bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sistemik Lupus Eritematozus Hastalığında C-Reaktif Protein ve Pentraksin-3 Düzeyleri Arasındaki İlişkinin Araştırılması
Authors: ASLANTAŞ Şükran , ORUÇOĞLU Nurdan , TÜRKEGÜN ŞENGÜL Merve , BALCI Senay , TAMER Lülüfer 
Published: February 2024

Amaç: Sistemik lupus eritematozus, çoklu otoantijenlere karşı poliklonal otoimmüniteyi içeren ve çok çeşitli klinik belirti spektrumuna sahip, öngörülemeyen seyirli otoimmün bir hastalıktır. Otoimmün hastalıklarda, uzun pentraksin ailesininden olan pentraksin-3 seviyelerinin dolaşımda arttığı bulunmuştur. Pentraksin-3, diğer pentraksinlerden farklı olarak periferal dokularda yerleşik ve doğal bağışıklık hücreleri tarafından, enflamatuar sinyallere cevap olarak üretilir. Bu çalışmada, kronik enflamasyon ve immün fonksiyon bozukluğu ile karakterize olan sistemik lupus eritematozus’da, inflamatuar belirteçlerden C-reaktif protein ve pentraksin-3 düzeyleri arasındaki ilişkinin araştırılması amaçlandı.
Yöntem: Çalışmaya, dahil edilme kriterlerine uyan, sistemik lupus eritematozus tanısı almış 56 hasta ve 55 sağlıklı birey dahil edildi. Tam kan sayımı, eritrosit sedimantasyon hızı, alanin transaminaz, kreatinin ve C-reaktif protein otoanalizörde çalışılırken; pentraksin-3 düzeyleri, serum örneklerinden, ELISA yöntemi ile çalışıldı.
Bulgular: Çalışma verileri incelendiğinde, hasta grubunda kontrol grubuna kıyasla hematolojik eritrosit sedimantasyon hızı sonuçları daha yüksek bulundu (p
Acil servise başvuran hastalarda venöz kan gazı parametrelerinin güvenilirliğinin retrospektif olarak değerlendirilmesi
Authors: ÖZÇETE Enver , UZ İlhan , TÜZER Gamze , SAĞMAN Şahin , LOMANOV Nurali 
Published: February 2024

Amaç: Çalışmamızda venöz kan gazı analizi parametrelerinin güvenilir olup olmadığını bulmayı amaçladık.
Yöntem: Acil servisimize 01.10.2021- 31.03.2022 tarihleri arasında başvuran 18 yaş üstü, hastalardan istenen kan tetkikleriyle eş zamanlı venöz kan gazı alınan hastalar çalışmaya alındı. Hastalardan alınan kan biyokimyasal tetkiklerinden (potasyum, sodyum, hemoglobin, hematokrit ve kan glukoz düzeyi) ve eş zamanlı alınan venöz kan gazında; Ph, potasyum, sodyum, hemoglobin, hematokrit ve kan glukoz düzeyi hasta alım formuna işlendi. Her parametre için Pearson korelasyon katsayıları hesaplandı; r 0.8 değeri güçlü bir korelasyon olarak kabul edildi. Merkezi biyokimya laboratuvarı oto analizörü ve venöz kan gazı analizi sonuçları arasındaki uyumu değerlendirmek için %95 güven aralığı (CI) uyum sınırları olan bir Bland-Altman testi kullanıldı.
Bulgular: Acil servise başvuran ve venöz kan gazı alınan 933 hastanın sonuçları incelendi ve 582 hasta çalışmaya alındı. Venöz kan gazı ve merkezi laboratuvar sonuçları arasındaki korelasyonlar değerlendirildiğinde glukoz düzeyi için (r=0.91), hemoglobin için (r=0.93), hematokrit için (r=0.89) ve potasyum için (r=0.80) güçlü bir korelasyon olduğu görüldü. sodyum için ise ( r=0.69) zayıf bir korelasyon vardı. Bland-Atman analizine göre klinik kullanım için potasyum, hemoglobin ve hemotokrit ölçümleri için kabul edilebilir uyum olmasına rağmen, glukoz ve sodyum ölçümleri için zayıf bir uyum olduğu bulundu.
Sonuç
Uyum limitleri dikkate alındığında potasyum, hemoglobin ve hemotokrit değerlerinin kabul edilebilir, glukoz ve sodyum değerleri kabul edilebilir değildi. Klinisyenlerin venöz kan gazı sonuçlarını kullanması gerektiğinde kısıtlılıkların farkında olmalıdır.
EXPLORING THE ROLE OF sFRP-4, TFF-3, NF-кB AND ROMO1 LEVELS IN COLORECTAL CANCER: IMPLICATIONS FOR PATHOPHYSIOLOGY AND DISEASE PROGRESSION
Authors: DURMUŞ Sinem , PAPİLA KUNDAKTEPE Berrin , GELİŞGEN Remise , PAPİLA Çiğdem , UZUN Hafize 
Published: February 2024

Objective: Colorectal cancer (CRC) is a significant global health concern with high morbidity and mortality rates. Early detection and accurate diagnostic tools are critical for managing the clinical course. This research explores the molecular landscape of CRC, aiming to provide valuable insights beyond traditional diagnostic approaches. The main aim of this study was to investigate the potential contribution of specific biomarkers, such as secreted frizzled associated protein-4 (sFRP-4), trefoil factor-3 (TFF-3), nuclear factor-kappa-B (NF-κB) and reactive oxygen species modulator-1 (Romo1), to understanding the pathophysiology and determining the progression of CRC.
Methods: This study analyzed plasma levels of sFRP-4, TFF-3, NF-κB and Romo1 in a cohort of patients with CRC (n=50) and age- and gender-matched control group (n=40), utilizing ELISA. The diagnostic performance of these biomarkers was assessed through Receiver Operating Characteristic (ROC) analysis.
Results: Our research revealed a significant increase in the levels of NF-κB, TFF-3 and Romo1 in patients with a diagnosis of CRC. Furthermore, these parameters were found to maintain elevated levels in patients with tumors larger than 4 cm as opposed to those with smaller tumors. Patients with metastases also had elevated levels of the three parameters compared with patients without metastases. The ROC analysis revealed that NF-κB showed the most promise as a parameter for distinguishing patients from control subjects, whereas TFF-3 displayed the most potential in identifying tumor size and the presence of metastasis.
Conclusion: This research contributes valuable insights into understanding the pathophysiology and progression of CRC. The potential roles of NF-κB, TFF-3, and Romo1 as biomarkers, as revealed in our study, offer a promising avenue for early detection and improved management of CRC. Further validation and prospective studies are necessary to clarify the roles of these biomarkers in the pathophysiological mechanism of CRC and to establish their clinical utility.
Effect of Antibiotic Prophylaxis on Infection Rates in Pediatric Supracondylar Humerus Fractures Treated with Closed Reduction and Percutaneous Pinning: A Prospective Double-Blinded Randomized Controlled Trial
Authors: Gupta Sumit K. , Esposito Ennio Rizzo , Phillips Rachel , Schwab Pierre-Emmanuel , Leary Emily V. , Hoernschemeyer Daniel G. 
Published: February 2024

Background:
Supracondylar humerus fractures (SCHFs) are the most common elbow fracture in the pediatric population. In the case of displaced fractures, closed reduction and percutaneous Kirschner wire pinning (CRPP) is commonly performed. Infection rates are between 0 and 7%; however, retrospective studies have shown no benefit of preoperative antibiotics. There continues to be notable variability in antibiotic usage based on surgeon preference and local institutional policy. We conducted a double-blinded, randomized controlled trial to evaluate whether antibiotic prophylaxis reduces the risk of infection in pediatric SCHF patients treated with CRPP.

Methods:
Pediatric patients with displaced SCHF who presented to a pediatric hospital were enrolled and randomized into two groups. Group I received one dose of prophylactic antibiotics (25 mg/kg cefazolin IV up to 1g or clindamycin 10 mg/kg up to 600 mg/kg IV in the case of cefazolin allergy). Group II received placebo (10-mL prefilled syringe of normal saline). All patients underwent CRPP and casting followed by pin removal 3 to 6 weeks after the initial procedure. The presence of pin-site infection, erythema, drainage, septic arthritis, and osteomyelitis was recorded.

Results:
One hundred sixty patients were enrolled in the study. Eighty-two patients were randomized to receive antibiotics, and 78 patients were randomized to placebo. No difference was seen in the rate of infection between the treatment groups (1.2% in the antibiotic group versus 1.3% in the placebo group; P = 1.00). Presence of purulent drainage (0.0% versus 1.3%; P = 0.49), septic arthritis (0.0% versus 0.0%; P = 1.00), and osteomyelitis (1.2% versus 0.0%; P = 1.00) was similar in both groups. No difference in the need for additional antibiotics (1.2% versus 1.3%; P = 1.00) or additional surgery (1.2% versus 0.0%; P = 1.00) was found between groups.

Discussion:
The use of antibiotic prophylaxis did not affect the risk of infection in pediatric patients who underwent CRPP for displaced SCHF.

Clinical Trial Registration:
ClinicalTrials.gov: NCT03261830.

Level of Evidence:
Therapeutic Level I.
OPTIMALISASI MASYARAKAT DAN MADRASAH SEBAGAI SUMBER BELAJAR DI DUKUH PUNDUHAN TIRTOMULYO KRETEK BANTUL
Authors: Herwinsyah  , Ibnu Abas Hersandi Muhamad 
Published: February 2024

Dukuh Punduhan merupakan salah satu Dukuh atau padukuhan yang terdapat di Desa Tirtomulyo. Keadaan wilayah Dukuh ini termasuk kedalam wilayah yang subur, sehingga sebagian warga Dukuh Punduhan bermata pencaharian sebagai petani dan peternak yang bekerja diladang. Program KKN Integratif di Dukuh Punduhan yang telah dijalankan antar lain meliputi program bidang keagamaan, bidang Kesehatan, bidang sosial, bidang ekonomi, bidang pendidikan, dan lingkungan hidup. Tujuan dari PKM ini untuk mengoptimalkan kemampuan seluruh aspek di wilayah ini dan menjadi sumber belajar dan ilmu pengetahuan, baik untuk mahasiswa juga untuk masyarakat dukuh punduhan. Metode yang dilakukan dengan melaksanakan seluruh proker yang telah disepakati bersama perangkat desa dengan rentang waktu selama 1 bulan. Hasil yang diperoleh adalah seluruh kegiatan berjalan dengan baik dan sesuai, seluruh lapisan masyarakat ikut berpartisipasi aktif dalam setiap penyelenggaraan kegiatan, baik kegiatan tingkat dukuh maupun kegiatan tingkat desa
PENINGKATAN KOMPETENSI GURU PADA PEMBELAJARAN BERBASIS ICT Di SD IT Yaumi Fatimah Pati
Authors: Abidin Muhammad , Adin Suryadin  
Published: February 2024

The presence of Information and Communication Technology (ICT) in learning is a challenge in itself for the world of education, in particular, learning technology today. Demands in responding to the globalization of education have appeared before our eyes. Various computer devices and their connections can deliver students to learn quickly and accurately if used correctly and appropriately. Therefore, it requires human resources who are responsive to ICT developments
Learning will be more fun if the teacher is able to make ICT-based teaching materials that can increase student creativity. With the use of ICT-based teaching materials in learning, the learning process will be more interesting and can make students more contextual. If we observe carefully, until now teachers have not been able to develop ICT-based learning. In the learning process, the teacher still uses the old method, namely teacher-centered learning, so that students are less able to develop their creativity.
This condition is also found in teachers at SD IT Yaumi Fatimah Pati. Where some teachers have not been able to carry out the ICT-based learning process, especially in compiling and making teaching materials, so that the learning process is only traditional, namely by lecturing, a little question and answer. Through community service activities, it will help teachers improve their competence in mastery of ICT which is useful in the learning process.
Toch minder ruimte voor het rechterlijk toezicht in het nieuwe wetboek? Beter ten halve gekeerd dan ten hele gedwaald
Authors: Samadi M. 
Published: February 2024

Toch minder ruimte voor het rechterlijk toezicht in het nieuwe wetboek? Beter ten halve gekeerd dan ten hele gedwaald
In mei 2022 publiceerde de Afdeling advisering van de Raad van State haar advies op het toenmalige wetsvoorstel van het nieuwe Wetboek van Strafvordering. In dit advies toonde de Afdeling zich in het bijzonder kritisch op een tweetal wijzigingen van de huidige regeling aangaande de rechterlijke reactie op onrechtmatigheden in het strafrechtelijk onderzoek, te weten de verruiming van de reikwijdte van de regeling en de invoering van het nieuwe criterium ‘het belang van een goede rechtsbedeling’ als normatief richtsnoer bij de toepassing van processuele sancties als reactie op onrechtmatig strafvorderlijk handelen. Inmiddels heeft de minister gehoor gegeven aan dit advies en deze voorgestelde wijzigingen in belangrijke mate teruggedraaid. Daardoor is het de vraag wat nu precies wordt beoogd met deze nieuwe regeling? In dit artikel vindt een kritische bespreking plaats van het advies van de Afdeling en de laatste versie van het wetsvoorstel. Beargumenteerd wordt dat juist deze twee wijzigingen een belangrijke bijdrage (hadden) kunnen leveren aan de volledigheid van het toezicht op de opsporing en roept in dat licht op tot (opnieuw) een herziening van de regeling.
Keberadaan Visum Et Reepertum Dalam Proses Peradilan Kasus Penganiayaan Keputusan Pengadilan Nomor 85/Pid.B/2022/Pn Semarang
Authors: I Made Raditya Mahardika  
Published: February 2024

. Hukum pidana adalah salah satu alternatif dalam menyelesaiakn masyarakat dalam menghadapi permasalahan yang menyangkut hak asasi manusia. Hukuman pidana itu sendiri harus adanya pembuktian baru bisa menentukan hukum pidana. Pembuktian adalah bagian yang sangat terpenting guna untuk menetapkan apakah seseorang yang disangkakan melakukan suatu tindak pidana bersalah dalam hal penganiayaan. Visum Et Repertum adalah suatu keterangan dokter yang memuat kesimpulan suatu pemeriksaan yang telah dilakukan misalnya atas penganiayaan seseorang untuk menentukan sebab penganiayaan dan lain sebagainya, keterangan mana diperlukan oleh hakim dalam suatu perkara. Tujuan Penelitian ini untuk menganalisis keberadaan Visum Et Repertum dalam proses pengadilan kasus penganiayaan. Metode penelitian menggunakan jenis penelitian yuridis normative, maka pendekatan yang digunakan dalam penelitian ini adalah: Pendekatan perundang-undangan (statue approach) dan Pendekatan konseptual (conceptual approach).Data penelitian akan dianalisis dengan menggunakan analisis deskriptif kualitatif. Hasil penelitian Proses pengadilan Hakim lebih mengutamakan keterangan Saksi-saksi dan Terdakwa, kemudian hakim membutuhkan alat bukti. Alat bukti yang dimaksud bukan hanya Visum et repertum bisa bukti yang lain dalam kasus ini pisau. Visum et repertum dalam proses pengadilan sebagai pendukung jadi bukan alat bukti utama, karena tanpa Visum et repertum, pengadilan tetap berjalan. Hal tersebut Keterangan terdakwa saja tidak cukup untuk membuktikan kesalahan yang didakwakan kepadanya, prinsip batas minimum pembuktian, pasal 183 KUHAP, harus disertai alat bukti lain pasal 189 ayat (4) KUHAP. Pasal 189 ayat (1) KUHAP menyatakan bahwa yang menjadi alat bukti yang sah adalah keterangan terdakwa dalam sidang pengadilan. Pemyataan terdakwa diluar sidang pengadilan dapat dipergunakan untuk menemukan bukti disidang pengadilan (pasal 189 ayat (2) KUHAP), asalkan keterangan diluar sidang tersebut didukung oleh alat bukti yang lain yang sah dan mengenai hal yang didakwakan kepadanya.
Kesimpulannya keberadaan Visum et repertum dalam proses pengadilan sebagai alat bukti pendukung untuk menilai kebenaran yang dihubungakan dengan keterangan terdakwa dan saksi. Pengadilan lebih diutamakan bukti dari keterangan terdakwa dan sanksi.
PEMBUATAN MEDIA PROMOSI CETAK MELIPUTI SPANDUK, MMT, KARTU NAMA DAN BROSUR DI PERUSAHAAN KAOS SEMARANG
Authors: Andik Prakasa Hadi  , Ahmad Zainudin  
Published: February 2024

Along with the development of increasingly modern times and increasingly sophisticated technology, many types of businesses are developing, one of which is a business in the convection field.
The promotional media that is currently running at the Nanang Kaos company currently uses print media, only in the form of a nameplate in front of the shop, but the promotion system using a nameplate is also less effective, because the existence of the Nanang Kaos company itself is in the village area and has never carried out promotional activities for attracting new consumers, this makes it difficult for the Nanang Kaos Company to develop and is not well known by the wider consumer.
So the author will add promotional media for the company, by adding print promotion media in the form of MMT Banners, Business Cards, and Brochures, it is hoped that consumers will know more about the products or services offered and know the existence of the company, which is a company engaged in convection.
Keywords: Print, Promotion, Media

ABSTRAK

Seiring dengan perkembangan zaman yang semakin modern dan teknologi yang semakin canggih, banyak sekali jenis usaha yang sedang berkembang, salah satunya adalah usaha dibidang konveksi. Media promosi yang sedang berjalan diperusahaan Nanang Kaos saat ini menggunakan media cetak, hanya berupa Papan Nama didepan Ruko, akan tetapi sistem promosi dengan menggunakan Papan Nama juga kurang efektif, dikarenakan keberadaan dari Perusahaan Nanang Kaos sendiri ada didaerah perkampungan dan belum pernah melakukan kegiatan promosi untuk menarik konsumen baru, hal ini menyebabkan Perusahaan Nanang Kaos sulit berkembang dan kurang begitu diketahui oleh konsumen luas.
Maka penulis akan menambah media promosi untuk perusahaan, dengan menambah media promosi cetak berupa Spanduk MMT, Kartu Nama, dan Brosur diharapkan konsumen lebih mengetahui produk atau jasa yang ditawarkan serta mengetahui keberadaan Perusahaan tersebut, yang merupakan sebuah perusahaan yang bergerak dibidang konveksi.

Kata Kunci: Media, Promosi, Cetak
A estratégia das “Superilles” em Barcelona, Espanha
Authors: Brizotti Pasquotto Geise , Fernandéz Baca Salcedo Rosio 
Published: February 2024

Objetivo do Estudo: Apresentar e investigar os impactos de uma estratégia inovadora denominada superilla, implantada na cidade de Barcelona (Espanha).
Metodologia: A pesquisa está dividida em duas etapas: i) Exploração teórica do conceito de superilla e de seus princípios sustentáveis (prioridade dos pedestres, diminuição do tráfego de veículos, mobilidade urbana, criação de espaços livres e áreas verdes, mobiliário urbano, diminuição da poluição do ar, entre outros) e ii) Análise dos impactos da superilla implantados na cidade de Barcelona, por meio dos estudos de caso: PobleNou e Sant Antoní.
Originalidade/Relevância: Ainda que a estratégia das superilles em Barcelona representem um marco para a sustentabilidade, há uma escassez de discussões sobre o assunto no contexto brasileiro.
Principais Resultados: O estudo delineou as fases de implantação das superilles e ressaltou seis pontos-chave da intervenção, como: i) hierarquia modal; ii) questão regional, iii) articulação entre projetos; iv) participação popular, v) modelo exportável e vi) renaturalização da cidade.
Contribuições: Esta pesquisa tem como foco investigar os processos ocorridos na intervenção urbana das superilles tornando seu entendimento mais aprofundado e divulgando tal processo no Brasil, de forma a contribuir para a divulgação de novas estratégias urbanas.
EDUKASI PENTINGNYA BUDAYA MENABUNG SEJAK DINI UNTUK BEKAL MASA DEPAN DALAM PERSPEKTIF EKONOMI ISLAM
Authors: Saleh Annisa Fadhilah , Salsabila Aura , Darpen Nor Hanifah , Ramadhan Rahmawati 
Published: February 2024

Wise financial management and early financial awareness play a crucial role in shaping an individual's future, especially in the context of Islamic values. This study introduces an educational program focused on the importance of cultivating a savings culture from an early age, with implementation taking place at Tahfiz Al Mumtaz Elementary School in Sekijang, Pelalawan Regency. In an effort to enrich students' knowledge and practices, students from STIES Imsya Pekanbaru are engaged as facilitators using lecture and savings simulation methods. The research attempts to evaluate the program's impact, with survey results indicating an improvement in students' understanding and positive responses from the school. By highlighting this educational approach, it is hoped to provide a strong foundation for fostering a sustainable savings culture, in line with Islamic financial principles, among the younger generation.
Pengelolaan keuangan yang bijak dan kesadaran finansial sejak dini memiliki peran krusial dalam membentuk masa depan individu, terutama dalam konteks nilai-nilai Islam. Studi ini mengenalkan sebuah program edukasi yang difokuskan pada pentingnya budaya menabung sejak dini, dengan implementasi yang dilakukan di Sekolah Dasar Tahfiz Al Mumtaz, Sekijang, Kabupaten Pelalawan. Dalam upaya memperkaya pengetahuan dan praktik siswa, mahasiswa dari STIES Imsya Pekanbaru terlibat sebagai fasilitator menggunakan metode ceramah dan simulasi menabung dengan celengan. Penelitian ini mencoba mengevaluasi dampak program, dengan hasil survei yang menunjukkan peningkatan pemahaman siswa serta tanggapan positif dari pihak sekolah. Dengan menyoroti pendekatan pendidikan ini, diharapkan dapat memberikan landasan yang kuat untuk membentuk budaya menabung yang berkelanjutan, sejalan dengan prinsip-prinsip keuangan Islam, di kalangan generasi muda.
Estrategias de afrontamiento ante estados emocionales en personas con diabetes tipo 2. Lodana, Manabí – Ecuador
Authors: Ponce Alencastro Jhon , Zamora Cevallos Ángel , Urdaneta Bracho Johan Smil , Semprún de Villasmil Blanca , Linares Giler Sandra María , Millán Hernández Eduardo Josué , Macías Avilés Gema Lisseth 
Published: February 2024

La diabetes tipo 2 (DT2) es un trastorno metabólico crónico que se caracteriza por la resistencia a la insulina y el fracaso de las células β pancreáticas que desemboca en un estado de hiperglucemia crónica. Determinar las estrategias de afrontamiento ante estados emocionales en personas con diabetes tipo 2 atendidos en el Centro de Salud de Lodana en la provincia de Manabí. Se trata de un estudio observacional, descriptivo, prospectivo, transversal, no experimental bajo el paradigma cuantitativo. La población de estudio estuvo constituida por 27 personas mayores de 18 años y mayores de 60 años con un intermedio etario en menores de 35 años de edad con diagnóstico confirmado de Diabetes tipo 2, miembros del club de diabéticos del centro de salud de Santa Ana parroquia Lodana durante el período de octubre 2021 a marzo 2022. Se pudo determinar que el mayor puntaje promedio lo obtuvo la estrategia de reevaluación positiva con puntuación de 17, 26; seguido por la estrategia búsqueda de apoyo social con 14,95; la estrategia religión 14,74; continuando con la estrategia focalización en la solución del problema 11,56. Las estrategias menos empleadas fueron la expresión emocional abierta con un puntaje de 6,70; la estrategia evitación con 15,07; seguido por la estrategia autofocalización negativa con 14,04; la estrategia evitación, obtuvo puntajes más altos en las mujeres en comparación a los hombres. Conclusión: Es importante hacer énfasis en las estrategias de afrontamiento ante el estrés, porque se pueden entender como recursos físicos y mentales necesarios para adoptar estilos de vida más saludables que generen bienestar de salud para sobrellevar enfermedades crónicas como la Diabetes tipo 2.