bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plastid genome of Chenopodium petiolare from Trujillo, Peru
Authors: Aliaga Flavio , Zapata-Cruz Mario , Valverde-Zavaleta Silvia Ana 
Published: March 2024

Abstract
Objectives
The Peruvian Andean region is an important center for plant domestication. However, to date, there have been few genetic studies on native grain, which limits our understanding of their genetic diversity and the development of new genetic studies for their breeding. Herein, we revealed the plastid genome of Chenopodium petiolare to expand our knowledge of its molecular markers, evolutionary studies, and conservation genetics.

Data description
Total genomic DNA was extracted from fresh leaves (voucher: USM < PER > :MHN333570). The DNA was sequenced using Illumina Novaseq 6000 (Macrogen Inc., Seoul, Republic of Korea) and reads 152,064 bp in length, with a large single-copy region of 83,520 bp and small single-copy region of 18,108 bp were obtained. These reads were separated by a pair of inverted repeat regions (IR) of 25,218 bp, and the overall guanine and cytosine (GC) was 37.24%. The plastid genome contains 130 genes (111 genes were unique and 19 genes were found duplicated in each IR region), including 86 protein-coding genes, 36 transfer RNA-coding genes, eight ribosomal RNA-coding genes, and 25 genes with introns (21 genes with one intron and four genes with two introns). The phylogenetic tree reconstructed based on single-copy orthologous genes and maximum likelihood analysis indicated that Chenopodium petiolare is most closely related to Chenopodium quinoa.
Bioinformatics analysis of photoexcited natural flavonoid glycosides as the inhibitors for oropharyngeal HPV oncoproteins
Authors: Pourhajibagher Maryam , Bahador Abbas 
Published: March 2024

AbstractThe presence of oropharyngeal human papillomavirus (HPV)-18 E6 and E7 oncoproteins is highly significant in the progression of oropharyngeal cancer. Natural flavonoid compounds have potential as photosensitizers for light-activated antimicrobial therapy against HPV-associated oropharyngeal cancer. This study evaluated five natural flavonoid glycosides including Fisetin, Kaempferol, Morin, Myricetin, and Quercetin as photosensitizers against HPV-18 E6 and E7 oncoproteins using computational methods. After obtaining the amino acid sequences of HPV-18 E6 and E7, various tools were used to predict and verify their properties. The PubChem database was then examined to identify potential natural flavonoid glycosides, followed by predictions of their drug-likeness and ADMET properties. Subsequently, molecular docking was conducted to enhance the screening accuracy and to gain insights into the interactions between the natural compounds and the active sites of HPV-18 E6 and E7 oncoproteins. The protein structures of E6 and E7 were predicted and validated to be reliable. The results of molecular docking demonstrated that Kaempferol exhibited the highest binding affinity to both E6 and E7. All compounds satisfied Lipinski's rules of drug-likeness, except Myricetin. They showed high absorption, distribution volume and similar ADMET profiles with no toxicity. In summary, natural flavonoid glycosides, especially Kaempferol, show potential as photosensitizers for antimicrobial photodynamic therapy against HPV-associated oropharyngeal cancer through inhibition of E6 and E7 oncoproteins. These findings provide insights into the development of novel therapeutic strategies based on antimicrobial photodynamic therapy.
Disclosure following a medical error: lessons learned from a national initiative of workshops with patients, healthcare teams, and executives
Authors: Finkelstein Adi , Brezis Mayer , Taub Amiad , Arad Dana 
Published: March 2024

Abstract
Background
Despite the increase in disclosures of medical errors, transparency remains a challenge. Recognized barriers include shame, fear of litigation, disciplinary actions, and loss of patient trust. In 2018, the Israeli Ministry of Health initiated a series of workshops about disclosure of medical errors. The workshops involved medical center executives, healthcare providers, patients, and family members of patients who had previously been harmed by a medical error. This study presents the lessons learned about perceived challenges in disclosure of errors in 15 such workshops.

Methods
Data collection included participant observations in 15 workshops, full audio recordings of all of the workshops, and documentation of detailed field notes. Analysis was performed under thematic analysis guidelines.

Results
We identified four main themes: “Providers agree on the value of disclosure of a medical error to the patient”; “Emotional challenges of disclosure of medical error to patients”; “The medico-legal discourse challenges transparency”; and “Providers and patients call for a change in the culture regarding disclosure of medical errors”. Participant observations indicated that the presence of a patient who had experienced a tragedy in another hospital, and who was willing to share it created an intimate atmosphere that enabled an open conversation between parties.

Conclusion
The study shows the moral, human, and educational values of open discourse in a protective setting after the occurrence of a medical error. We believe that workshops like these may help foster a culture of institutional disclosure following medical errors. We recommend that the Ministry of Health extend such workshops to all healthcare facilities, establish guidelines and mandate training for skills in disclosure for all providers.
Factors affecting growth and internationalization of micro-enterprises in a sparsely populated region: case South Savo, Finland
Authors: Partala Timo , Jantunen Sami , Kuukkanen Tommi , Merikoski Helena 
Published: March 2024

AbstractMicro-enterprises have recently received increased research attention due to their contribution to economic growth and employment, and an increasing amount of research has focused on studying their performance. The current objective was to study factors affecting the growth and internationalization of micro-enterprises, as well as the most important barriers for growth in the sparsely populated region of South Savo in Finland. Owners or managers of 108 micro-enterprises responded to a questionnaire probing variables representing aspects of growth, internationalization, innovation, networking, digital maturity, and business environment, among others. Statistical analyses including multiple regressions were used to analyze the data collected on quantitative rating scales. The results suggested that intention to grow and level of networking with other companies and public actors were directly related to actualized growth. Intention to grow was, in turn, affected by innovativeness, growth capability, intention for internationalization, and business environment. In addition, the level of innovativeness and intention for internationalization were related to actual level of internationalization. The most important barriers for growth selected by the participants were lack of time for development activities, threshold to hire new employees, and sufficiency of funding. The results were utilized in guiding regional development activities in the South Savo region.
Social support and mental well-being among people with and without chronic illness during the Covid-19 pandemic: evidence from the longitudinal UCL covid survey
Authors: Aksoy Ozan , Wu Alison Fang-Wei , Aksoy Sevgi , Rivas Carol 
Published: March 2024

Abstract
Purpose
An immediate research priority recovering from the COVID-19 pandemic is well-being among some of our most vulnerable—people with chronic illness. We studied how mental health changed among people with and without chronic illness throughout the pandemic and the mediating role of social support.

Methods
We used the 3-waves of COVID-19 survey within the Millennium Cohort Study (MCS, age 19, N = 5522) and MCS Parent (MCSP, age > > 19, N = 7479) samples, with additional pre-pandemic measures of some outcomes and exposure. Using Structural Equation Panel Models with Full Information Maximum Likelihood estimation to address missing data, we studied differences between respondents with a chronic illness and without, regarding depressive symptoms and mental well-being, with social provision, social support, and loneliness as potential mediators.

Results
Mental well-being (SWEMWBS) and psychological distress (Kessler-6) worsened significantly during the pandemic relative to baseline for people with and without chronic illness, while the latter group had substantially better well-being at all waves and the baseline regarding both outcomes. When the lockdown was lifted during wave-2, mental well-being temporarily rebounded, and distress waned among people without chronic illness but continued to worsen among people with chronic illness. Social support partially mediated the link between chronic illness and mental well-being.

Conclusions
The large mental well-being gap between people with and without chronic illness persisted during the pandemic. However, social support and provision can partially narrow this gap, hence should be employed in future pandemic management.
Meaningfulness experienced in performing domestic labor in Chinese families: a qualitative study from caregivers’ perspectives
Authors: Zhang Bo , Coene Gily 
Published: March 2024

AbstractThe intricately connected interactions among personal choices, traditional cultural ideologies, and modern societal backgrounds have provoked dynamic interpretations and practices in performing domestic labor. The value of domestic labor in terms of macro considerations, such as reproductive value, economic value, and caring value, has been established in scholarly discussions. In China, the emphasis is on the meaningfulness of domestic care for the whole society. However, it remains unclear how family members in contemporary Chinese society understand the meaningfulness of performing domestic labor. This study aims to investigate what kinds of meaning that individuals derive from their day-to-day domestic labor and how the different types of meaningfulness affect their future behaviors in sharing domestic responsibilities. Meaningfulness is a complex notion, but Baumeister’s theory of meaning provides a theoretical framework to understand why humans need meaningfulness in life, the forms that meaningfulness takes, where meaningfulness resides, and how perceptions of meaningfulness are shaped. In total, 48 respondents participated in semi-structured, in-depth interviews concerning their attitudes toward the value of domestic labor. Findings based on in-depth interview data show that the meaningfulness of domestic labor consists of participants realizing their need for belonging, self-efficacy, and a sense of living a good life. These results also suggest that the values of domestic labor illustrated in previous studies, in which domestic labor was conceptualized as reproductive labor, economic activity, and care labor, have little effect on individuals’ lives. Nevertheless, the meaningfulness that individuals experience in daily life continues to motivate their devotion to domestic labor. Finally, the discursive mechanism shaping the meaningfulness of domestic labor is also discussed.
Biosecurity measures for the prevention of African swine fever on German pig farms: comparison of farmers’ own appraisals and external veterinary experts’ evaluations
Authors: Klein Leonie , Gerdes Ursula , Blome Sandra , Campe Amely , grosse Beilage Elisabeth 
Published: March 2024

Abstract
Background
Since its first introduction into the German wild boar population in 2020, African swine fever (ASF) has been spreading slowly from the eastern border westwards and has been introduced into eight domestic pig farms thus far. The European Food Safety Authority has named deficits in farm biosecurity and increased human activity as major risk factors for the introduction of the ASF virus into pig farms. Studies have shown that pig farms in Germany generally have a high level of biosecurity. However, veterinary practitioners and policy-makers have expressed concerns that not all pig farmers are appropriately prepared to deal with the threat of ASF. This study aimed to evaluate the level of biosecurity on pig farms in Lower Saxony and explore the reasons for deficits in the implementation of biosecurity measures. For this purpose, pig farmers were interviewed in open structured face-to-face interviews about their perception of ASF and biosecurity, and the implemented measures on their farms were assessed with a checklist. In the data analysis, the farmers’ answers and the results of the biosecurity check were compared to gain further insights into the factors influencing the implementation of biosecurity measures on the farms.

Results
The biosecurity check showed that on most farms, a high level of biosecurity had been implemented. Nevertheless, deficits were found concerning the fences and the delimitation of clean and dirty areas on farm grounds and in the anteroom. Overall, the farmers were well informed about ASF and had a realistic perception of their own biosecurity. They considered the farm layout, financial means and practicality of hygiene measures to be the main barriers to implementing biosecurity measures against ASF. However, the results also suggested that farmers’ attitudes and legal regulations were major influencing factors.

Conclusion
The results indicated a high level of biosecurity against ASF on most pig farms and a realistic perception of their own biosecurity by the farmers. Current knowledge transfer and information should focus on building upon the farmers’ own motivation and expertise and supporting them to put existing knowledge into practice.
An analysis of the correlation between income and the consumption of energy in Bangladesh
Authors: Shabur Md. Abdus , Ali Md. Farhad 
Published: March 2024

AbstractThis research takes a methodical look at how rising incomes and climate change affect energy use in six different divisions of Bangladesh. To investigate the indirect mechanism of income influence on the consumption of energy, this study employs indicators of industrial structure upgrading and urbanization in a novel way using the fixed effects model which has not been used so far in this kind of study. The results show that income affects energy use in two ways: directly and indirectly. The influence of income on the consumption of energy is inverted U-shaped and may be readily observed. Furthermore, by encouraging urbanization and upgrading of industrial structure, income can indirectly lower energy use. While energy consumption is negatively impacted by climate change, it is less severe than the effect on earnings. Furthermore, there are substantial geographical and temporal variations in the effect of wealth on energy use. Energy use decreases significantly as income rises over time. Income has a detrimental effect on the consumption of energy in the developed southern area. Energy usage is positively affected by income in the undeveloped northern area. In light of Bangladesh’s unique the consumption of energy profile, we must reject the “one size fits all” approach and instead concentrate on reducing wasteful spending in areas like income growth, industrial structure and urbanization, and while simultaneously increasing efficiency and precision in our aiming. This study aims to provide policymakers with fresh insights to inform decisions on energy production and consumption policies considering urbanization and industrial growth.
Needle artifact reduction during interventional CT procedures using a silver filter
Authors: Reynoso-Mejia Carlos A. , Troville Jonathan , Wagner Martin G. , Hoppel Bernice , Lee Fred T. , Szczykutowicz Timothy P. 
Published: March 2024

Abstract
Background
MAR algorithms have not been productized in interventional imaging because they are too time-consuming. Application of a beam hardening filter can mitigate metal artifacts and doesn’t increase computational burden. We evaluate the ability to reduce metal artifacts of a 0.5 mm silver (Ag) additional filter in a Multidetector Computed Tomography (MDCT) scanner during CT-guided biopsy procedures.

Methods
A biopsy needle was positioned inside the lung field of an anthropomorphic phantom (Lungman, Kyoto Kagaku, Kyoto, Japan). CT acquisitions were performed with beam energies of 100 kV, 120 kV, 135 kV, and 120 kV with the Ag filter and reconstructed using a filtered back projection algorithm. For each measurement, the CTDIvol was kept constant at 1 mGy. Quantitative profiles placed in three regions of the artifact (needle, needle tip, and trajectory artifacts) were used to obtain metrics (FWHM, FWTM, width at − 100 HU, and absolute error in HU) to evaluate the blooming artifact, artifact width, change in CT number, and artifact range. An image quality analysis was carried out through image noise measurement. A one-way analysis of variance (ANOVA) test was used to find significant differences between the conventional CT beam energies and the Ag filtered 120 kV beam.

Results
The 120 kV-Ag is shown to have the shortest range of artifacts compared to the other beam energies. For needle tip and trajectory artifacts, a significant reduction of − 53.6% (p < 0.001) and − 48.7% (p < 0.001) in the drop of the CT number was found, respectively, in comparison with the reference beam of 120 kV as well as a significant decrease of up to − 34.7% in the artifact width (width at − 100 HU, p < 0.001). Also, a significant reduction in the blooming artifact of − 14.2% (FWHM, p < 0.001) and − 53.3% (FWTM, p < 0.001) was found in the needle artifact. No significant changes (p > 0.05) in image noise between the conventional energies and the 120 kV-Ag were found.

Conclusions
A 0.5 mm Ag additional MDCT filter demonstrated consistent metal artifact reduction generated by the biopsy needle. This reduction may lead to a better depiction of the target and surrounding structures while maintaining image quality.
Accurate and efficient floor localization with scalable spiking graph neural networks
Authors: Gu Fuqiang , Guo Fangming , Yu Fangwen , Long Xianlei , Chen Chao , Liu Kai , Hu Xuke , Shang Jianga , Guo Songtao 
Published: March 2024

AbstractFloor localization is crucial for various applications such as emergency response and rescue, indoor positioning, and recommender systems. The existing floor localization systems have many drawbacks, like low accuracy, poor scalability, and high computational costs. In this paper, we first frame the problem of floor localization as one of learning node embeddings to predict the floor label of a subgraph. Then, we introduce FloorLocator, a deep learning-based method for floor localization that integrates efficient spiking neural networks with powerful graph neural networks. This approach offers high accuracy, easy scalability to new buildings, and computational efficiency. Experimental results on using several public datasets demonstrate that FloorLocator outperforms state-of-the-art methods. Notably, in building B0, FloorLocator achieved recognition accuracy of 95.9%, exceeding state-of-the-art methods by at least 10%. In building B1, it reached an accuracy of 82.1%, surpassing the latest methods by at least 4%. These results indicate FloorLocator’s superiority in multi-floor building environment localization.
Prevalence and pattern of psychiatric morbidity in patients with first-episode acute coronary syndrome
Authors: Akbar Nighat , Farooq Kubra , Jan Neelofar , Zahoor Marya , Rather Yasir Hassan , Bhat Ubaid Rasool 
Published: March 2024

Abstract
Background
The existing body of literature extensively highlights the impact of psychological determinants on the initiation of coronary heart disease. Globally, the incidence of psychiatric disorders is increasing, and India is no stranger to this trend. However, the connection between psychiatric co-morbidities and the onset of acute coronary syndrome has been relatively understudied in this region of the world.

Results
Individuals experiencing acute coronary syndrome exhibited notably higher psychiatric morbidity compared to the control group, with an odds ratio of 4.14. Mood disorders, in particular, were the most prevalent among ACS patients, demonstrating an odds ratio of 5.023, followed by anxiety disorders with an odds ratio of 2.48.

Conclusion
The findings revealed a substantial association underscoring the intricate interplay between mental and cardiovascular health emphasizing the importance of holistic healthcare approaches that consider both physical and psychological well-being, in the context of cardiovascular diseases. Further research in this area can contribute to a more comprehensive understanding of the links between mental health and cardiovascular outcomes, potentially informing targeted interventions and improving overall patient care.
Effectiveness and safety of SOF/VEL containing rescue therapy in treating chronic HCV-GT4 patients previously failed NS5A inhibitors-based DAAs
Authors: Omar Heba , Maksoud Mohammed Hamdy Abdel , Goma Ahmed A. , Hassan Essam A. , Atta Nancy Abdalla , Khalil Mahmoud , Hegazy Mohamed Soliman , Zaky Samy , Esmat Gamal 
Published: March 2024

Abstract
Background and aims
NS5A inhibitors are an important option for treating chronic HCV-GT4 patients. Retreatments after NS5A-based DAAs failure are limited. We aimed to determine the effectiveness and safety of SOF/VEL-containing regimens for HCV retreatment after NS5A-regimen failure.

Methods
Prospective cohort study assessing the efficacy and safety of retreatment with SOF/VEL in addition to either voxilaprevir or ribavirin in patients who had failed previous NS5A-based DAA treatment. The primary outcome was SVR12. Safety and tolerability data were collected.

Results
One hundred fifty patients were included. The mean age was 53 years, 64% were male, and 50% of included patients had liver cirrhosis, with a mean FIB-4 score of 3.12 (± 2.30) and Child-Turcotte-Pugh (CTP) score of 7.27 (± 0.48), and failed previous SOF/DCV + RBV, they were assigned to 24 weeks of SOF/VEL + RBV. The remaining 50% of participants had no liver cirrhosis and failed previous SOF/DCV, they were assigned to 12 weeks of treatment with SOF/VEL/VOX. Overall, SVR12 was achieved by 96% (n = 144/150) of included patients; 97.33% for SOF/VEL/VOX and 94.67% for SOF/VEL/RBV. Thirty-one patients experienced mild AEs; the most commonly reported mild AE in the SOF/VEL + RBV group was hyperbilirubinemia (n = 9) whereas in the SOF/VEL/VOX group were headache (n = 4) and vertigo (n = 4). Only one patient in SOF/VEL + RBV reported moderate treatment-related AE in the form of anemia and no reported severe AE.

Conclusion
Retreatment of non-cirrhotic patients with 12 weeks SOF/VEL/VOX and treatment of cirrhotic patients with 24 weeks with SOF/VEL + RBV after the failure of first-line NS5A-based therapy was an effective and well-tolerated treatment option.