bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stereoselective Synthesis of δ‐Heteroaryl Substituted β‐Hydroxy‐γ,δ‐unsaturated α‐Amino Acids.
Authors: Cremonesi Giuseppe , Dalla Croce Piero , Fontana Francesco , La Rosa Concetta 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regioselective Entry to Bromo‐γ‐hydroxybutenolides: Useful Building Blocks for Assemblying Natural Product‐Like Libraries.
Authors: Aquino M. , Bruno I. , Riccio R. , Gomez‐Paloma L. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Functionalization of Novel Tetrathia[7]helicenes as New Push—Pull Systems
Authors: Licandro Emanuela , Rigamonti Clara , Ticozzelli Maria Teresa , Monteforte Marco , Baldoli Clara , Giannini Clelia , Maiorana Stefano 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Substituted Dihydroindole Derivatives by Intermolecular Couplings of Samarium Ketyls and Indoles.
Authors: Blot Virginie , Reissig Hans‐Ulrich 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 3‐(Diarylmethylenyl)oxindole by a Palladium‐Catalyzed Domino Carbopalladation/C—H Activation/C—C Bond‐Forming Process.
Authors: Pinto Artur , Neuville Luc , Retailleau Pascal , Zhu Jieping 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Practical Method for the Synthesis of Indolylaryl‐ and Bisindolylmaleimides (V).
Authors: Roy Sudipta , Roy Sujata , Gribble Gordon W. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Unexpected Formation of 2‐Aryl‐3‐benzyl‐1,3‐thiazolidin‐4‐ones.
Authors: Cunico Wilson , Capri Liliane R. , Gomes Claudia R. B. , Sizilio Rosangela H. , Wardell Solange M. S. V. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel Synthesis of Bis‐(1,2,4‐triazolyl)‐3‐disulfides
Authors: Liu Tian‐Bao , Jiang Wen‐Qing , Zou Jian‐Ping , Zeng Run‐Sheng 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Pd(II)‐Catalyzed Asymmetric Addition of Malonates to Dihydroisoquinolines.
Authors: Sasamoto Naoki , Dubs Christian , Hamashima Yoshitaka , Sodeoka Mikiko 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ionic Liquid Mediated Knoevenagel Condensation of Meldrum′s Acid and Aldehydes.
Authors: Darvatkar Nitin B. , Deorukhkar Amol R. , Bhilare Sachin V. , Salunkhe Manikrao M. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 6‐[4‐(Allyl/phenyl)‐5‐thioxo‐1,2,4‐triazol‐3‐yl]pyrimidine‐2,4‐diones (II) and Their Reaction with Electrophiles.
Authors: Mekuskiene G. , Vainilavicius P. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Antibacterial Activity of Nitroaryl Thiadiazole‐Levofloxacin Hybrids.
Authors: Foroumadi Alireza , Mansouri Shahla , Emami Saeed , Mirzaei Javad , Sorkhi Maedeh , Saeid‐Adeli Nosratollah , Shafiee Abbas 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Identification of a Novel Boron‐Containing Antibacterial Agent (AN0128) (I) with Antiinflammatory Activity, for the Potential Treatment of Cutaneous Diseases.
Authors: Baker Stephen J. , et al. et al. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Selective Approach to 1,1‐Bis(silyl)‐2‐arylethenes and 1,1‐Bis(silyl)‐1,3‐butadienes via Sequential Silylative Coupling—Heck Coupling Reactions.
Authors: Pawluc Piotr , Hreczycho Grzegorz , Marciniec Bogdan 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Domino Ring‐Closing Enyne‐Metathesis—Cross‐Metathesis Approach to 1‐Phosphonylated Benzazepines.
Authors: Dieltiens Nicolai , Stevens Christian V. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Organocatalytic Highly Enantioselective Synthesis of Secondary α‐Hydroxyphosphonates.
Authors: Dodda Rajasekhar , Zhao Cong‐Gui 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Synthesis of a Chiral Building Block for Cyclopentanoids: A Novel Enantioselective Synthesis of Preclavulone A.
Authors: Zanoni Giuseppe , Porta Alessio , Brunoldi Enrico , Vidari Giovanni 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Total Synthesis and Structure Determination of the Antiherpetic Anthrapyran Antibiotic AH‐1763 IIa.
Authors: Tietze Lutz F. , Gericke Kersten M. , Singidi Ramakrishna Reddy 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Potent Cytotoxic Rocaglamide Derivatives from the Fruits of Amoora cucullata.
Authors: Chumkaew Parinuch , Kato Shigeru , Chantrapromma Kan 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Design and Synthesis of Phosphonodifluoromethyl Phenylalanine (F2Pmp): A Useful Phosphotyrosyl Mimetic
Authors: Burke Terrence R. Jr. 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Recent Results on A‐Ring Modification of 1α,25‐Dihydroxyvitamin D3: Design and Synthesis of VDR‐Agonists and Antagonists with High Biological Activity
Authors: Saito Nozomi , Honzawa Shinobu , Kittaka Atsushi 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hybrid Molecules Between Distamycin A and Active Moieties of Antitumor Agents
Authors: Baraldi Pier Giovanni , Preti Delia , Fruttarolo Francesca , Tabrizi Mojgan Aghazadeh , Romagnoli Romeo 
Published: February 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Amniotic fluid can act as an appetitive unconditioned stimulus in preweanling rats
Authors: Arias Carlos , Chotro M.G. 
Published: February 2007

AbstractStudies in humans and animals indicate that exposure to flavors in the amniotic fluid during the later gestational period may induce preferences for those flavors. Considering that during the last prenatal period the amniotic fluid contains substances that activate the opioid system, and that this system plays a critical role in the acquisition of olfactory preferences early in life, it has been hypothesized that the amniotic fluid may acquire appetitive unconditioned properties during this period. This has been tested in an experiment in which preweanling rats were exposed to alcohol odor (CS) paired or unpaired with the intraoral infusion of amniotic fluid (US) collected on gestational day 20. The pairing of these two stimuli induced an enhanced palatability of alcohol's flavor as well an increased intake of the drug. These results support the idea that amniotic fluid acquires appetitive unconditioned properties during the last days of gestation and suggest that associative mechanisms involving the amniotic fluid could be underlying odor and taste preferences acquired through fetal exposure. © 2007 Wiley Periodicals, Inc. Dev Psychobiol 49: 139–149, 2007.
The effect of repetition on imitation from television during infancy
Authors: Barr Rachel , Muentener Paul , Garcia Amaya , Fujimoto Melissa , Chávez Verónica 
Published: February 2007

AbstractAlthough television exposure levels during infancy are high, the impact of such exposure on learning is relatively unknown. Initial studies have shown that infants imitate significantly fewer target actions from a televised demonstration than they imitate from a live demonstration. It was hypothesized that increasing the duration of exposure to the videotaped demonstration would increase learning from television. Independent groups of 12‐ to 21‐month‐olds were exposed to live or videotaped demonstrations of target actions, and imitation of the target actions was measured 24 hr later. The video segment duration was twice that of the live presentation. Doubling exposure increased levels of imitation performance in the video groups to that of the live groups, and both groups exceeded baseline performance. These results are consistent with the perceptual encoding impoverishment theory, and we conclude that repeated exposure enhances encoding of the target actions from a 2D television source. © 2007 Wiley Periodicals, Inc. Dev Psychobiol 49: 196–207, 2007.
JNK2 negatively regulates CD8+ T cell effector function and anti‐tumor immune response
Authors: Tao Jian , Gao Yunfei , Li Ming O. , He Weifeng , Chen Liang , Harvev Bohdan , Davis Roger J. , Flavell Richard A. , Yin Zhinan 
Published: February 2007

AbstractJNK1 and JNK2 have distinct effects on activation, differentiation and function of CD8+ T cells. Our early studies demonstrated that JNK1 is required for CD8+ T cell‐mediated tumor immune surveillance. However, the role of JNK2 in CD8+ T cell response and effector functions, especially in anti‐tumor immune response, is unknown. To define the role of JNK2 in antigen‐specific immune response, we have investigated CD8+ T cells from OT‐1 CD8+ transgenic mice in response to either high‐ or low‐affinity peptides. JNK2–/– CD8+ T cells proliferated better in response to both peptides, with more cell division and less cell death. In addition, JNK2–/– CD8+ T cells produced higher levels of IFN‐γ, which is associated with increased expression of T‐bet and Eomesodermin (Eomes). Moreover, JNK2–/– CD8+ T cells expresses high levels of granzyme B and show increased CTL activity. Finally, the enhanced expansion and effector function of JNK2–/– CD8+ T cells was further evidenced by their capacity to delay tumor growth in vivo. In summary, our results demonstrate that JNK2 negatively regulates antigen‐specific CD8+ T cell expansion and effector function, and thus selectively blocking JNK2 in CD8+ T cells may potentially enhance anti‐tumor immune response.
A Theoretical Study of the Nearest Cu···Cu Antiferromagnetic Exchange Coupling Interactions in [LaCu6] and [YCu6]
Authors: Zhang Yi‐Quan , Luo Cheng‐Lin 
Published: February 2007

AbstractA density functional study of the exchange coupling interactions between the two nearest CuII centers in [LaCu6] and [YCu6] is presented. Two approaches show that the Cu···Cu antiferromagnetic interactions increase with a decrease of the ionic radius of the diamagnetic central LaIII and YIII ions. However, the influence of the central ions on the Cu···Cu interactions is small compared to that of their structures according to our calculations. We therefore conclude that the stronger antiferromagnetic interactions between the two nearest CuII centers in [LaCu6] than in [YCu6] are not a result of the central LaIII ion but the structure. The antiferromagnetic contributions of the direct overlap between the two nearest CuII magnetic orbitals also play a major role according to the calculations of the overlap integral Sij based on Kahn's theory.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Meroterpenoid Pigments from Albatrellus flettii (Basidiomycetes)
Authors: Koch Barbara , Steglich Wolfgang 
Published: February 2007

AbstractThe pigments responsible for the blue colour of the North American polypore Albatrellus flettii have been isolated and their structures elucidated by spectroscopic methods. Albatrellin, a dimeric meroterpenoid with a furylbenzoquinone chromophore, is accompanied by its 16‐hydroxy and 16‐oxo derivatives. The latter has recently been described as grifolone B from a Japanese collection of A. caeruleoporus. Based on the idea that albatrellin is formed in nature by oxidative coupling of a grifolinquinone with the furan derivative cristatin, the blue pigment was synthesized in vitro. The reaction could be applied to the synthesis of several analogues.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
A combined analytical approach reveals novel EXT1/2 gene mutations in a large cohort of Italian multiple osteochondromas patients
Authors: Signori Emanuela , Massi Emanuela , Matera Maria Giovanna , Poscente Monica , Gravina Carolina , Falcone Gianluca , Rosa Michele Attilio , Rinaldi Monica , Wuyts Wim , Seripa Davide , Dallapiccola Bruno , Fazio Vito Michele ,   Clinical reference groups
Published: February 2007

AbstractMultiple osteochondromas (MO), also known as hereditary multiple exostoses (HME), is one of the most common hereditary musculoskeletal diseases in Caucasians (1/50,000) with wide clinical variability and genetic heterogeneity. Two genes have thus far been identified as causing the disease, namely EXT1 and EXT2. Various methods to detect mutations in the EXT genes have been used. Here a cohort of 100 MO patients belonging to unrelated Italian families have been analyzed by single‐strand conformation polymorphism (SSCP) analysis or by denaturing high performance liquid chromatography (DHPLC). However, neither of these techniques can detect deletions or duplications of entire exons. Families that were negative at SSCP/DHPLC analysis underwent two‐color multiple ligation‐dependent probe amplification (MLPA) analysis. By these complementary techniques mutation detection was significantly improved and 26 novel mutations have been revealed as well as 18 previously described mutations to give a total of 44 different mutations. Thus we can conclude that combining MLPA with DHPLC in point‐mutations negative MO families, the detection of mutations in EXT genes can significantly improve the identification of both point‐mutations and mid‐size rearrangements. More important, we were able to characterize all those patients who were negative at the first PCR‐based method screening. © 2007 Wiley‐Liss, Inc.
The effects of memory, attention, and executive dysfunction on outcomes of depression in a primary care intervention trial: the PROSPECT study
Authors: Bogner Hillary R. , Bruce Martha L. , Reynolds Charles F. , Mulsant Benoit H. , Cary Mark S. , Morales Knashawn , Alexopoulos George S. 
Published: February 2007

AbstractObjectiveTo describe the influence of domains of cognition on remission and response of depression in an intervention trial among older primary care patients.MethodsTwenty primary care practices were randomly assigned to Usual Care or to an Intervention consisting of a depression care manager offering algorithm‐based care for depression. In all, 599 adults 60 years and older with a depression diagnosis were included in these analyses. Depression severity and remission of depression were assessed by the 24‐item Hamilton Depression Rating Scale. The Mini‐Mental State Examination (MMSE) was our global measure of cognitive function. Verbal memory was assessed with the memory subscale of the Dementia Rating Scale. Attention was measured with the digit span from the Weschler Adult Intelligence Test. Response inhibition, one of the executive functions, was assessed with the Stroop Color‐Word test.ResultsThe intervention was associated with improved remission and response rates regardless of cognitive impairment. Response inhibition as measured by the Stroop Color‐Word test appeared to significantly modify the intervention versus usual care difference in remission and response at 4 months. Patients in the poorest performance quartile at baseline on the Stroop Color‐Word test in the Intervention Condition were more likely to achieve remission of depression at 4 months than comparable patients in Usual Care [odds ratio (OR) = 17.76, 95% Confidence Interval (CI), 3.06, 103.1].ConclusionsDepressed older adults in primary care with executive dysfunction have low remission and response rates when receiving usual care but benefit from depression care management. Copyright © 2007 John Wiley & Sons, Ltd.
The concept of hydrological connectivity and its contribution to understanding runoff‐dominated geomorphic systems
Authors: Bracken Louise J. , Croke Jacky 
Published: February 2007

AbstractThe term ‘connectivity’ is increasingly being applied in hydrological and geomorphological studies. Relevant research encompasses aspects of landscape connectivity, hydrological connectivity and sedimentological connectivity. Unlike other disciplines, notably ecology, published studies show no consensus on a standard definition. This paper provides an overview of how existing research relates to the concept of connectivity in both ecology and hydrology by proposing and evaluating a conceptual model of hydrological connectivity that includes five major components: climate; hillslope runoff potential; landscape position; delivery pathway and lateral connectivity. We also evaluate a proposed measure of connectivity called the volume to breakthrough to quantify changing connectivity between different environments and catchments. Copyright © 2007 John Wiley & Sons, Ltd.
Pollinex® Quattro Ragweed: safety evaluation of a new allergy vaccine adjuvanted with monophosphoryl lipid A (MPL®) for the treatment of ragweed pollen allergy
Authors: Baldrick Paul , Richardson Derek , Woroniecki Stefan R. , Lees Beverley 
Published: February 2007

AbstractA novel allergy vaccine (Pollinex® Quattro Ragweed) has been developed for the prevention or relief of allergic symptoms caused by pollen from Ambrosia spp. (ragweed). An extract from the pollen (chemically modified by glutaraldehyde) is adsorbed onto l‐tyrosine with addition of the immunostimulatory adjuvant, monophosphoryl lipid A (MPL®). A specific preclinical safety testing strategy was developed to support clinical use and comprised reference to preclinical data available for the marketed non‐MPL® adjuvanted form of the ragweed vaccine (Pollinex® R) and a new repeat dose toxicity study in the rat. Studies with Pollinex® R comprised single dose subcutaneous toxicity studies in mice and rats, repeat dose (10 injections over 20 days) parenteral toxicity studies in rats and dogs, an in vitro gene mutation assay along with single and multiple injection local tolerance studies in rats and dogs. The repeat dose subcutaneous toxicity study with Pollinex® Quattro Ragweed involved seven injections over 3 weeks (which was more aggressive than the four weekly doses used in the clinic) with dose levels of up to 0.5 ml per animal used. Overall, the product showed no toxicological findings of significance at levels greatly in excess of those proposed for clinical use. As is a feature with vaccination, some dose site irritation was seen. Copyright © 2007 John Wiley & Sons, Ltd.
Angiotensin II type 1 and bradykinin B2 receptors expressed in early stage epithelial cells derived from human embryonic stem cells
Authors: Huang Zhenhua , Yu Jun , Toselli Paul , Bhawan Jag , Sudireddy Vasanthi , Taylor Linda , Polgar Peter 
Published: February 2007

AbstractWhen human embryonic stem (hES) cells were placed into suspension culture followed by culture on BD matrigel™ coated plates in the presence of medium conditioned by NIH‐3T3 cells, they differentiated into cells of which more than 95% stained positive for keratin 8 by day 14, demonstrating that the hES cells had committed to an epithelial lineage. Approximately 50% of the keratin 8 staining cells became positive for cytokeratin 14 after 26 days. Binding experiments supported by real time PCR showed that the expression of bradykinin B2 (BKB2) and angiotensin II type 1 (AT1) receptors accompanied this differentiation. Neither receptor was expressed in the pluripotent H9 stem cells. However, transduction of the hES cells with lentivirus containing BKB2 or AT1R cDNA resulted in ligand binding and ERK1/2 activation but not in Gαi or Gαq coupled signaling. In the differentiated cells, both BKB2R and AT1R were expressed constitutively and effected typical Gαi and Gαq coupled signaling characterized by the release of arachidonate, generation of inositol phosphates, and Ca2+ mobilization. These signals were abolished by the receptor antagonists, losartan, and HOE 140. Angiotensin II and bradykinin also stimulated the phosphorylation of ERK1/2, JNK1/2, and p70S6 in the differentiated cells. Our results demonstrate that human embryonic stem cells can be differentiated effectively into the epithelial lineage and that when differentiated express functional, signaling AT1 and BKB2 receptors. J. Cell. Physiol. 211: 816–825, 2007. © 2007 Wiley‐Liss, Inc.