bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptions of family‐of‐origin belief systems among men in treatment for sexual offending: A phenomenological investigation
Authors: Huebner Jessie , Fickling Melissa J. 
Published: March 2024

AbstractSexual offending is a public concern and results in lasting detrimental effects. Despite evidence demonstrating the impact of belief systems on sexual offending behaviors, research exploring family belief systems among individuals who perpetrate sexual offenses is limited. This qualitative study explored the lived experiences of 10 cisgender men in outpatient treatment for sexual offending. Following Interpretative Phenomenological Analysis (IPA), findings indicated a broad range of early experiences for men who have sexually offended. The rich findings that emerged from the lived experiences of the participants are presented in relation to current knowledge, and practice implications are shared.
Resveratrol prevents cognitive deficits induced by sleep deprivation via modulating sirtuin 1 associated pathways in the hippocampus
Authors: Zhang Yue‐Ming , Wei Ru‐Meng , Zhang Jing‐Ya , Liu Shuang , Zhang Kai‐Xuan , Kong Xiao‐Yi , Ge Yi‐Jun , Li Xue‐Yan , Chen Gui‐Hai 
Published: March 2024

AbstractAccumulating evidence confirms that sleep insufficiency is a high risk factor for cognitive impairment, which involves inflammation and synaptic dysfunction. Resveratrol, an agonist of the Sirt1, has demonstrated anti‐inflammation and neuroprotective effects in models of Alzheimer's disease, Parkinson's disease, and schizophrenia. However, the beneficial effects of resveratrol on sleep deprivation‐induced cognitive deficits and its underlying molecular mechanisms are unclear. In the present study, thirty‐two male C57BL/6 J mice were randomly divided into a Control+DMSO group, Control+Resveratrol group, SD+DMSO group, and SD+Resveratrol group. The mice in the SD+Resveratrol group underwent 5 days of sleep deprivation after pretreatment with resveratrol (50 mg/kg) for 2 weeks, while the mice in the SD+DMSO group only underwent sleep deprivation. After sleep deprivation, we evaluated spatial learning and memory function using the Morris water maze test. We used general molecular biology techniques to detect changes in levels of pro‐inflammatory cytokines and Sirt1/miR‐134 pathway‐related synaptic plasticity proteins. We found that resveratrol significantly reversed sleep deprivation‐induced learning and memory impairment, elevated interleukin‐1β, interleukin‐6, and tumor necrosis factor‐α levels, and decreased brain‐derived neurotrophic factor, tyrosine kinase receptor B, postsynaptic density protein‐95, and synaptophysin levels by activating the Sirt1/miR‐134 pathway. In conclusion, resveratrol is a promising agent for preventing sleep deprivation‐induced cognitive dysfunction by reducing pro‐inflammatory cytokines and improving synaptic function via the Sirt1/miR‐134 pathway.
State‐of‐the‐art in transposable element modulation affected by drugs in malignant prostatic cancer cells
Authors: Terrazzan Anna , Vanini Riccardo , Ancona Pietro , Bianchi Nicoletta , Taccioli Cristian , Aguiari Gianluca 
Published: March 2024

AbstractOver recent years, the investigation of transposable elements (TEs) has granted researchers a deeper comprehension of their characteristics and functions, particularly regarding their significance in the mechanisms contributing to cancer development. This manuscript focuses on prostate carcinoma cell lines and offers a comprehensive review intended to scrutinize the associations and interactions between TEs and genes, as well as their response to treatment using various chemical drugs, emphasizing their involvement in cancer progression. We assembled a compendium of articles retrieved from the PubMed database to construct networks demonstrating correlations with genes and pharmaceuticals. In doing so, we linked the transposition of certain TE types to the expression of specific transcripts directly implicated in carcinogenesis. Additionally, we underline that treatment employing different drugs revealed unique patterns of TE reactivation. Our hypothesis gathers the current understanding and guides research toward evidence‐based investigations, emphasizing the association between antiviral drugs, chemotherapy, and the reduced expression of TEs in patients affected by prostate cancer.
Synergy of machine learning and density functional theory calculations for predicting experimental Lewis base affinity and Lewis polybase binding atoms
Authors: Huynh Hieu , Le Khanh , Vu Linh , Nguyen Trang , Holcomb Matthew , Forli Stefano , Phan Hung 
Published: March 2024

AbstractInvestigation of Lewis acid–base interactions has been conducted by ab initio calculations and machine learning (ML) models. This study aims to resolve two critical tasks that have not been quantitatively investigated. First, ML models developed from density functional theory (DFT) calculations predict experimental BF3 affinity with Pearson correlation coefficients around 0.9 and mean absolute errors around 10 kJ mol−1. The ML models are trained by DFT‐calculated BF3 affinity of more than 3000 adducts, with input features readily obtained by rdkit. Second, the ML models have the capability of predicting the relative strength of Lewis base binding atoms in Lewis polybases, which is either an extremely challenging task to conduct experimentally or a computationally expensive task for ab initio methods. The study demonstrates and solidifies the potential of combining DFT calculations and ML models to predict experimental properties, especially those that are scarce and impractical to empirically acquire.
Pathophysiological mechanisms of cardiomyopathies induced by desmin gene variants located in the C‐Terminus of segment 2B
Authors: Geryk Michelle , Charpentier Flavien 
Published: March 2024

AbstractDesmin, the most abundant intermediate filament in cardiomyocytes, plays a key role in maintaining cardiomyocyte structure by interconnecting intracellular organelles, and facilitating cardiomyocyte interactions with the extracellular matrix and neighboring cardiomyocytes. As a consequence, mutations in the desmin gene (DES) can lead to desminopathies, a group of diseases characterized by variable and often severe cardiomyopathies along with skeletal muscle disorders. The basic desmin intermediate filament structure is composed of four segments separated by linkers that further assemble into dimers, tetramers and eventually unit‐length filaments that compact radially to give the final form of the filament. Each step in this process is critical for proper filament formation and allow specific interactions within the cell. Mutations within the desmin gene can disrupt filament formation, as seen by aggregate formation, and thus have severe cardiac and skeletal outcomes, depending on the locus of the mutation. The focus of this review is to outline the cardiac molecular consequences of mutations located in the C‐terminal part of segment 2B. This region is crucial for ensuring proper desmin filament formation and is a known hotspot for mutations that significantly impact cardiac function.
The discount consolidation effect: How brands can present quantity discounts more effectively
Authors: Yang Haiyang , Chakravarti Dipankar 
Published: March 2024

AbstractHow should brands present quantity discounts to increase consumer appeal? We propose that, compared to distributed presentations that spread a discount across units (e.g., buy two, get 30% off on each unit), consolidated presentations that place the discount on a single unit (e.g., buy two, get 60% off on the second unit) can lead to a higher purchase likelihood. Four studies demonstrate this “discount consolidation effect” across a variety of consumption contexts, product categories and price levels. The studies show that this effect occurs because compared to consolidated presentations of a quantity discount, distributed presentations can lead to less favorable perceptions about the quality of the discounted product and about the savings offered. We also identify an important boundary condition, illustrating that when the discount offered is substantively small in size, the effect is attenuated. These findings add to the theoretical literature and offer actionable managerial insights.
Resurgence of ethanol seeking following voluntary abstinence produced by nondrug differential reinforcement of other behavior
Authors: Craig Andrew R. , Agnew Charlene N. , Derrenbacker Kate E. , Antúnez Beatriz Arroyo , Sullivan William E. , Smith Sean W. , DeBartelo Jacqueline , Roane Henry S. 
Published: March 2024

AbstractResurgence refers to the relapse of a target behavior following the worsening of a source of alternative reinforcement that was made available during response elimination. Most laboratory analyses of resurgence have used a combination of extinction and alternative reinforcement to reduce target behavior. In contingency‐management treatments for alcohol use disorder, however, alcohol use is not placed on extinction. Instead, participants voluntarily abstain from alcohol use to access nondrug alternative reinforcers. Inasmuch, additional laboratory research on resurgence following voluntary abstinence is warranted. The present experiment evaluated resurgence of rats' ethanol seeking following voluntary abstinence produced by differential reinforcement of other behavior (DRO). Lever pressing produced ethanol reinforcers during baseline phases. During DRO phases, lever pressing continued to produce ethanol and food reinforcers were delivered according to resetting DRO schedules. Ethanol and food reinforcers were suspended during resurgence test phases to evaluate resurgence following voluntary abstinence. Lever pressing was elevated during baseline phases and occurred at near‐zero rates during DRO phases. During the resurgence test phases, lever pressing increased, despite that it no longer produced ethanol. The procedure introduced here may help researchers better understand the variables that affect voluntary abstinence from ethanol seeking and resurgence following voluntary abstinence.
Patient‐specific cutting guides increase accuracy of medial opening wedge high tibial osteotomy procedure: A retrospective case‐control study
Authors: Fayard Jean‐Marie , Saad Maxime , Gomes Lucas , Kacem Sami , Abid Hichem , Vieira Thais D. , Lambrey Pierre‐Jean , Ollivier Matthieu , Thaunat Mathieu 
Published: March 2024

AbstractPurposeTo compare the accuracy of patient‐specific guides (PSCG) to the standard technique in medial open‐wedge high tibial osteotomy (OWHTO). Secondary objectives were to evaluate factors that could influence accuracy and to compare the complication rate and operating time for both procedures.MethodsA retrospective analysis of prospective collected data was performed. Between March 2011 and May 2018, 49 patients with isolated medial knee osteoarthritis who were operated for OWHTO using PSCG and 38 patients using the standard technique were included. Preoperative and postoperative deformities were evaluated on long leg radiographs by measuring the mechanical medial proximal tibial angle, mechanical lateral distal femoral angle, hip knee ankle angle (HKA), and joint line convergence angle. Pre‐ and postoperative posterior tibial slope was also evaluated. Accuracy was evaluated by analysing the difference between the preoperative planned and the actual postoperative HKA. Operating time and complication rate were also recorded in both groups.ResultsThe mean preoperative HKA was 173.4° (±3.1°) in the PSCG group and 173.3° (±2.4°) in the standard group (p = 0.8416). Mean planned HKA were 182.8° (±1.1°) and 184.0° (±0°) respectively for the PSCG and the standard group. Mean postoperative HKA were 181.9° (±1.9°) and 182.6° (±3.1°) respectively for the PSCG and the standard group. An accuracy of ±2° in the HKA was achieved in 44 (90%) in the PSCG group and 24 (65%) in the standard group (p = 0.006). The probability of achieving a HKA accuracy was four times higher for patients in the PSCG group (odds ratio [OR] = 4.06, [1.1; 15.3], p = 0.038). Also, higher preoperative Ahlback grade was associated with precision, all other parameters being equal (OR = 4.2, [0.13; 0.97], p = 0.04).ConclusionIn this study, the PSCG technique was significantly more accurate for achieving the planned HKA in OWHTO. Complication rates and operating times were comparable between groups.Level of EvidenceLevel IV, case‐control study.
Comprehensive analysis of histone acetylation‐related genes in glioblastoma and lower‐grade gliomas: Insights into drug sensitivity, molecular subtypes, immune infiltration, and prognosis
Authors: Qin Jiajun , Fu Jin , Chen Xianzhen 
Published: March 2024

AbstractObjectivesThe purpose of this research was to study the impact of histone acetylation on glioblastoma multiforme (GBM) and lower‐grade gliomas (LGG) and its potential implications for patient prognosis. We aimed to assess the histone acetylation score (HAs) and its relationship with key genes involved in histone acetylation regulation.MethodThe TCGA‐GBMLGG dataset, which provides comprehensive genomic and clinical information, was utilized for this study. We calculated the HAs by analyzing the expression levels of histone acetylation‐related genes, including histone acetyltransferases and histone deacetylases, in GBM and LGG patients. Kaplan–Meier survival analysis was performed to evaluate the prognostic value of the HAs. Furthermore, correlation analysis and differential expression analysis were conducted to assess the relationship between the HAs and key genes involved in histone acetylation regulation, as well as the expression differences of immune checkpoint genes.ResultsOur analysis revealed a significant association between the HAs and patient prognosis, with higher HAs correlating to poorer outcomes in GBM and LGG patients. We observed a positive correlation between the HAs and key genes involved in histone acetylation regulation, indicating their potential role in modulating histone acetylation levels. Moreover, we found significant expression differences for immune checkpoint genes between high and low HAs groups, suggesting a potential impact of histone acetylation on the immune response in GBM and LGG.ConclusionThis study highlights the significance of histone acetylation in GBM and LGG. The HAs demonstrated prognostic value, indicating its potential as a clinically relevant biomarker. The correlation between the HAs and key genes involved in histone acetylation regulation provides insights into the underlying mechanisms driving histone acetylation dysregulation in GBM and LGG. Furthermore, the observed expression differences of immune checkpoint genes suggest a potential link between histone acetylation and the immune response. These findings contribute to our understanding of the molecular basis of GBM and LGG and have implications for personalized treatment approaches targeting histone acetylation and the immune microenvironment. Further validation and functional studies are needed to confirm these findings and explore potential therapeutic strategies.
Gender mismatch and bias in people‐centric operations: Evidence from a randomized field experiment
Authors: Son Yoonseock , Choi Angela Aerry , Wowak Kaitlin D. , Angst Corey M. 
Published: March 2024

AbstractResearch at the interface of operations management (OM) and gender bias has mostly focused on operational outcomes such as hiring decisions on behalf of the employer (or firm). Largely overlooked is how the design of operational processes exacerbates (or diminishes) the amount of gender bias exhibited on behalf of the customer in a people‐centric operations environment. In this study, we conduct a randomized field experiment with a partner firm to assess gender mismatch and bias in client‐consultant exchanges. The experimental design enables us to examine gender bias within dyadic exchanges when there are gender matches (female client‐female consultant or male client‐male consultant) or gender mismatches (female client‐male consultant or male client‐female consultant). We find that reporting the consultant's gender significantly increases the client's likelihood of leaving more and higher reviews, increases the clickthrough rate on recommended products, and that the effect is stronger for females than for male consultants. We also provide support for the heterogenous effects of client experience depending on the gender (mis)match in client‐consultant exchanges, including whether the prior effects hold when there is gender masking or manipulation (e.g., reported female consultant when actually male). Our findings offer important theoretical contributions and practical implications for OM scholars and managers.
Pannexin 3 deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running
Authors: Wakefield Brent , Tang Justin , Hutchinson Jeffrey L. , Kanji Rehanna , Brooks Courtney , Grol Matthew W. , Séguin Cheryle A. , Penuela Silvia , Beier Frank 
Published: March 2024

AbstractPannexin 3 (Panx3) is a glycoprotein that forms mechanosensitive channels expressed in chondrocytes and annulus fibrosus cells of the intervertebral disc (IVD). Evidence suggests Panx3 plays contrasting roles in traumatic versus aging osteoarthritis (OA) and intervertebral disc degeneration (IDD). However, whether its deletion influences the response of joint tissue to forced use is unknown. The purpose of this study was to determine if Panx3 deletion in mice causes increased knee joint OA and IDD after forced treadmill running. Male and female wildtype (WT) and Panx3 knockout (KO) mice were randomized to either a no‐exercise group (sedentary; SED) or daily forced treadmill running (forced exercise; FEX) from 24 to 30 weeks of age. Knee cartilage and IVD histopathology were evaluated by histology, while tibial secondary ossification centers were analyzed using microcomputed tomography (µCT). Both male and female Panx3 KO mice developed larger superficial defects of the tibial cartilage after forced treadmill running compared with SED WT mice. Additionally, Panx3 KO mice developed reduced bone volume, and female PANX3 KO mice had lengthening of the lateral tubercle at the intercondylar eminence. In the lower lumbar spine, both male and female Panx3 KO mice developed histopathological features of IDD after running compared to SED WT mice. These findings suggest that the combination of deleting Panx3 and forced treadmill running induces OA and causes histopathological changes associated with the degeneration of the IVDs in mice.
Land degradation and development in India: Status quo, challenges and opportunities
Authors: Singh Kripal , Agrawala Meghna , Dhyani Shalini , Mishra Nivedita , Bauddh Kuldeep , Byun Chaeho 
Published: March 2024

AbstractThis article reviews and synthesizes the articles published in a virtual special issue (VSI) “Land Degradation and Development in India: Status quo, challenges, and opportunities.” A total of 31 studies (28 research papers and three reviews) are published in this VSI covering various agroclimatic zones of India. These articles provide insights on how different natural and anthropogenic disturbances affect the diversity, and functioning of forests, grasslands, agriculture, agroforestry, and physicochemical and biological composition of the soil. Twelve of these articles also investigate the effectiveness of different restoration methods to restore various degraded ecosystems through agroforestry, afforestation and reforestation, organic amendments, and agroecological interventions. The historical journey of forest restoration, behavioral pattern of local communities for conservation and restoration, and policy framework for restoration in India are discussed in three independent articles. Overall, there is convergence in learnings from these papers for structural and non‐structural land degradation, soil salinization, and agroforestry but results from papers on plantations and organic inputs into farming highlight the need for more research.
Quality of life, adherence and knowledge of epileptic patients and the impact of a pharmacist‐led educational intervention: A review
Authors: Munaf Zahraa Abbas , Mohammed Samer Imad 
Published: March 2024

AbstractAround 65 million individuals suffer from epilepsy worldwide, and when it is not properly treated, it is linked to higher rates of physical harm and mortality. Due to the requirement for long‐term therapy and the side effects of many medications, medication compliance is a significant issue. The purpose of this review was to summarize the findings of previous studies examining the quality of life (QOL), adherence, patient education, and medication knowledge, as well as the impact of a pharmacist‐led educational intervention. Additionally, to find out if these studies benefit epileptic patients, to find the appropriate method used to help them in all aspects of their lives, and to use these in future studies. A systematic and comprehensive search was conducted using specific keywords from PubMed, Google Scholar, and Research Gate. A significantly poorer QOL was linked to prolonged antiepileptic drug use or poor adherence as well as psychiatric problems. Neglect was the most frequent reason for nonadherence. The frequency of seizures was greatly reduced, and the adherence was significantly increased by patient education and medication understanding. Patient awareness, adherence, QOL, and seizure frequency were dramatically improved following the intervention. In the absence of optimal treatment, epilepsy is associated with increased rates of bodily injuries and mortality. It is crucial to increase patient education and knowledge about disease and treatment in order to improve adherence, and QOL. Intervention by a chemist is required to achieve these results.
Increasing the scan‐efficiency of pulmonary imaging at 0.55 T using iterative concomitant field and motion‐corrected reconstruction
Authors: Javed Ahsan , Ramasawmy Rajiv , Ozenne Valéry , Su Pan , Chow Kelvin , Campbell‐Washburn Adrienne 
Published: March 2024

AbstractPurposeTo develop an iterative concomitant field and motion corrected (iCoMoCo) reconstruction for isotropic high‐resolution UTE pulmonary imaging at 0.55 T.MethodsA free‐breathing golden‐angle stack‐of‐spirals UTE sequence was used to acquire data for 8 min with prototype and commercial 0.55 T MRI scanners. The data was binned into 12 respiratory phases based on superior–inferior navigator readouts. The previously published iterative motion corrected (iMoCo) reconstruction was extended to include concomitant field correction directly in the cost function. The reconstruction was implemented within the Gadgetron framework for inline reconstruction. Data were retrospectively reconstructed to simulate scan times of 2, 4, 6, and 8 min. Image quality was assessed using apparent SNR and image sharpness. The technique was evaluated in healthy volunteers and patients with known lung pathology including coronavirus disease 2019 infection, chronic granulomatous disease, lymphangioleiomyomatosis, and lung nodules.ResultsThe technique provided diagnostic‐quality images, and image quality was maintained with a slight loss in SNR for simulated scan times down to 4 min. Parenchymal apparent SNR was 4.33 ± 0.57, 5.96 ± 0.65, 7.36 ± 0.64, and 7.87 ± 0.65 using iCoMoCo with scan times of 2, 4, 6, and 8 min, respectively. Image sharpness at the diaphragm was comparable between iCoMoCo and reference images. Concomitant field corrections visibly improved the sharpness of anatomical structures away from the isocenter. Inline image reconstruction and artifact correction were achieved in <5 min.ConclusionThe proposed iCoMoCo pulmonary imaging technique can generate diagnostic quality images with 1.75 mm isotropic resolution in less than 5 min using a 6‐min acquisition, on a 0.55 T scanner.