bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Perbedaan Jenis Kelamin dengan Jumlah Densitas Alur Sidik Jari dan White Lines pada Mahasiswa Kedokteran Universitas Udayana Angkatan 2016 – 2018
Authors: Soesilopranoto Leonardo Wiranata , Rustyadi Dudut , Alit Ida Bagus Putu 
Published: March 2024

Identifikasi forensik atau identifikasi personal merupakan upaya yang dilakukan pihak penyidik untuk menentukan identitas dan ciri-ciri seseorang termasuk jenis kelamin. Identifikasi jenis kelamin merupakan langkah yang penting untuk mempersempit kemungkinan tersangka kasus. Sidik jari adalah metode identifikasi yang memiliki tingkat keakuratan yang paling tinggi. Sidik jari dapat memberikan profil identifikasi lain yang penting seperti ras, golongan darah, dan jenis kelamin akan tetapi membutuhkan waktu yang lama dan proses yang susah. Terdapat metode yang mudah dan cepat untuk mengidentifikasi yaitu melalui jumlah densitas alur sidik jari dan white lines. Kedua hal tersebut dipengaruhi oleh banyak hal seperti ras, usia, indeks massa tubuh, dsb. Karena itu perlu dilakukan penelitian lebih lanjut untuk melihat apakah terdapat perbedaan yang signifikan jumlah densitas alur sidik jari dan white lines antara kedua jenis kelamin pada mahasiswa kedokteran Universitas Udayana angkatan 2016-2018. Penelitian ini bersifat observational analitik, pengambilan sampel penelitian menggunakan metode stratified random sampling dan dilakukan dalam sekali waktu (cross-sectional). Terdapat 83 sampel yang berasal dari mahasiswa Program Studi Sarjana Kedokteran dan Profesi Dokter di Universitas Udayana angkatan 2016-2018. Sidik jari diambil menggunakan metode ink, lalu diamati menggunakan kaca pembesar untuk menghitung densitas alur sidik jari pada ruang hitung dan white lines. Berdasarkan hasil analisis, didapatkan bahwa terdapat perbedaan yang signifikan rata-rata jumlah densitas alur sidik jari pada ketiga ruang hitung (p = 0,001; p = 0,001; p = 0,0001) dan rata-rata jumlah white lines (p = 0,029) antar kedua jenis kelamin pada mahasiwa Program Studi Sarjana Kedokteran dan Profesi Dokter di Universitas Udayana.
Difusi Teknologi Lubang Resapan Biopori di Musim Penghujan untuk Antisipasi Kelangkaan Air Sumur di Musim Kemarau
Authors: Firdaus Feris 
Published: March 2024

Curah bujan yang sudah mulai tinggi menyebabkan terjadinya genangan air hujan di kawasan Komplek Masjid Al-Muhajirin, Tiyasan, Kelurahan Condongcatur, Kecamatan Depok, Sleman, D.I.Yogyakarta. Selain itu, genangan air yang terjadi saat hujan di kawasan Komplek Masjid Al-Muhajirin tersebut dipicu oleh maraknya program pengecoran jalan-jalan perkampungan dan ruas-ruas halaman rumah warga yang juga dicor beton dan paving block dalam beberapa tahun terakhir yang tidak didukung dengan drainase yang memadahi. Hasil kegiatan pengabdian masyarakat yang dilakukan di lokasi tersebut menunjukkan bahwa masyarakat sangat antusias dalam difusi teknologi lubang resapan biopori tersebut. Kegiatan pengabdian masyarakat ini dimulai dengan tahapan pelatihan di serambi masjid yang diikuti oleh takmir masjid dan jama’ah masjid yang tinggal di sekitar kawasan masjid. Materi yang disampaikan berupa konsep teknis difusi teknologi lubang resapan biopori berikut peralatan dan bahan yang diperlukan yakni alat bor tanah secara manual berbentuk T dengan ukuran panjang 1 m dan pipa PVC dengan ukuran diameter 4 inch beserta penutupnya yang sudah dilubangi menggunakan alat solder listrik. Tahapan berikutnya adalah praktik pembuatan lubang resapan biopori menggunakan alat adan bahan tersebut yang dilakukan secara pasrtisipatori yakni berdasarkan hasil pelatihan lantas masyarakat dapat mengimplementasikan pengetahuannya untuk membuat lubang resapan biopori yang didampingi pengabdi secara langsung. Pada tahapan praktik ini dihasilkan produk percontohan lubang resapan biopori dengan kedalaman 50 cm sebanyak 2 lubang resapan lengkap dengan 2 pipa PVC yang sudah dilubangi beserta tutupnya yang sudah siap meresapkan air hujan yang turun kemudian.
Kata Kunci: difusi, lubang resapan, biopori, air hujan, air sumur.
Mangled Thumb Injury Reconstruction with the Use of Definitive External Fixation and the Masquelet Technique
Authors: Berkay Fehmi , Schneider Andrew , Minhas Arjun , Wimalawansa Sunishka 
Published: March 2024

Case:
A 23-year-old right-hand dominant man presented with a high-velocity gunshot wound injury to the right thumb with severe soft-tissue damage, vascular injury, and large osseous defect of the right thumb metacarpal. The patient was successfully treated with metacarpophalangeal joint arthrodesis and metacarpal reconstruction using definitive external fixation, an intramedullary Kirschner wire, and use of the Masquelet bone grafting technique.

Conclusion:
The authors' treatment approach for a mangled thumb injury with definitive external fixation and utilization of the Masquelet technique resulted in restoration of a large osseous defect, avoidance of infection, and limited loss of mobility.
Autism-related gene intergenerationally regulates neurodevelopment and behavior in fish through non-genetic mechanisms
Authors: Clément Antoine , Merdrignac Constance , Puiggros Sergi Ruig , Brionne Aurélien , Nguyen Thaovi , Montfort Jerome , Guyomar Cervin , Dauvé Alexandra , Herpin Amaury , Jabaudon Denis , Colson Violaine , Murat Florent , Bobe Julien 
Published: March 2024

Abstract
Parental stress can impact progeny neurodevelopment and long-term behavior through gamete-mediated non-genetic inheritance (i.e., by mechanisms that do not involve transmission of genetic alleles). While intergenerational effects have been studied in males, maternal non-genetic mechanisms shaping long-term progeny behavior remain unknown in vertebrates. We focused on AUTS2, a gene maternally repressed in the fish oocyte following maternal stress and associated with human neurodevelopmental disorders (NDDs). Here we show, using a model fish species, that maternal auts2a (the ortholog of human AUTS2) loss of function impacts progeny long-term behavior and modulates gene expression in neural cells during early neurodevelopment, including NDD-associated genes. We found that auts2a expression in the mother/oocyte regulates maternally-inherited factors, particularly transcriptional and post-transcriptional regulators required for early embryonic development before zygotic genome activation. Our results unravel a non-genetic mechanism of maternal inheritance and shed new light on the intergenerational determinism of neurodevelopment and behavior in a vertebrate species. Moreover, we found that AUTS2 belongs to a group of 45 evolutionarily-conserved oocyte genes, associated with behavior and neurodevelopment in vertebrates and linked to severe human diseases, raising the question of the role of maternal factors in the determinism of NDDs.
The Efficacy and Mechanism of Kaempferol in Preventing perioperative neurocognitive disorders in the Elderly: Based on Network Pharmacology and Experimental Verification
Authors: Huang Enhao , LI Huadao , Han Hanghang , Liang Yubing , Huang Zijin , Qin Ke , Du Xueke 
Published: March 2024

Abstract
Objective:This research, founded on network pharmacology, molecular docking, and experimental validation, seeks to elucidate the probable therapeutic effects of Kaempferol on perioperative neurocognitive disorders，along with its operational mechanism.
Methods:Key target points for the potential preventive effects of Kaempferol (Kae) on perioperative neurocognitive disorders (PND) were discerned through the Geo database and network pharmacology techniques. An animal model was established for PND through laparotomy. The model and therapeutic outcomes were verified using the Morris water maze (MWM) and Open field tests, subsequently, mechanisms of hub target regulation were confirmed through methods such as qPCR In vivo and in vitro experimental models were utilized to study the impact of Kae on microglial cell activation and inflammation, as well as Kae's rescuing effect on neuronal apoptosis, thereby exploring its neuroprotective action mechanism.
Results:Network pharmacology analysis revealed that Kae could potentially exert its therapeutic effect by regulating key targets such as p-AKT1, p-JUN, PPARG, and caspase-3. These targets primarily function within inflammation and immune modulation related pathways such as the AGE-RAGE signaling pathway, TNF-α signaling pathway, and apoptosis. In vivo and in vitro model experiments demonstrated that Kae significantly influenced the activation and inflammatory response of microglial cells, indicating possible neuroprotective effects. Additionally, Kae was able to mitigate the apoptosis of primary neurons induced by LPS, a phenomenon that Kae rescues in a concentration-dependent manner.
Conclusion:By regulating key targets such as p-AKT1, p-JUN, PPARG, and caspase-3, Kaempferol might play a role in the prevention and treatment of PND, demonstrating neuroprotective and cognitive function improvement effects.
Sex Bias in Prediction and Diagnosis of Cardiac Surgery Associated Acute Kidney Injury
Authors: Demirjian Sevag , Huml Anne , Bakaeen Faisal , Poggio Emilio , Geube Mariya , Shaw Andrew , Gillinov A. Marc , Gadegbeku Crystal A. 
Published: March 2024

Abstract
Background
Female sex has been recognized as a risk factor for cardiac surgery associated acute kidney injury (CS-AKI). The current study sought to evaluate whether female sex is a risk factor for CS-AKI, or modifies the association of peri-operative change in serum creatinine with CS-AKI.
Methods
Observational study of adult patients undergoing cardiac surgery between 2000 and 2019 in a single U.S. center. The main variable of interest was registered patient sex, identified from electronic medical records. The main outcome was CS-AKI within 2 weeks of surgery.
Results
Of 58526 patients, 19353 (33%) were female; 12934 (22%) incurred AKI based on ≥ 0.3 mg/dL or ≥ 50% rise in serum creatinine (any AKI), 3320 (5.7%) had moderate to severe AKI, and 1018 (1.7%) required dialysis within 2 weeks of surgery. Female sex was associated with higher risk for AKI in models that were based on preoperative serum creatinine (OR, 1.35; 95% CI, 1.29–1.42), and lower risk with the use of estimated glomerular filtration, (OR, 0.90; 95% CI, 0.86–0.95). The risk for moderate to severe CS-AKI for a given immediate peri-operative change in serum creatinine was higher in female compared to male patients (p < .0001 and p < .0001 for non-linearity), and the association was modified by pre-operative kidney function (p < .0001 for interaction).
Conclusions
The association of patient sex with CS-AKI and its direction was dependent on the operational definition of pre-operative kidney function, and differential outcome misclassification due to AKI defined by absolute change in serum creatinine.
On the Origins of Mass
Authors: Szweizer Moshe , Schlagbaum Rivka 
Published: March 2024

Abstract
Probability, as manifested through entropy, is presented in this study as one of the most fundamental components of physical reality. It is demonstrated that the quantization of probability allows for the introduction of the mass phenomenon. In simple terms, gaps in probability impose resistance to change in movement, which observers experience as inertial mass. The model presented in the paper builds on two probability fields that are allowed to interact. The resultant probability distribution is quantized, producing discrete probability levels. Finally, a formula is developed that correlates the gaps in probability levels with physical mass. The model allows for the estimation of quark masses. The masses of the proton and neutron are arrived at with an error of 0.02%. The masses of sigma baryons are calculated with an error between 0.007% and 0.2%. The W-boson mass is calculated with an error of 1.3%. The model explains why proton is stable while other baryons are not.
Resilience and Responses to El Niño Costero 2017: A Multidimensional Impact Analysis in Peru
Authors: ANGULO ELEAZAR CHUCHON , ORSINI JOSE ANTONIO MARENGO 
Published: March 2024

Abstract
This study examines the multifaceted impacts and responses to the El Niño Costero 2017 in Peru, emphasizing the event's socio-economic, environmental, and infrastructural repercussions. Utilizing a comprehensive analysis approach, the research delves into the effectiveness of disaster management strategies implemented and their outcomes on community resilience. Key findings highlight the critical areas of vulnerability and the adaptive measures adopted, offering insights for enhancing future disaster preparedness and response mechanisms.
Estimation of fracture-strike azimuth by QVOA analysis validated by simulated seismic data of physical modeling
Authors: Chichinina Tatiana , Sabinin Vladimir , Avila-Carrera Rafael , Polovkov Viacheslav , Popov Dmitry , Ding Pinbo 
Published: March 2024

Abstract

Vertical fractures cause azimuthal anisotropy. To predict the fractures’ azimuth, we use anisotropy analysis of the seismic attribute QVOA. The QVOA means “Q Versus Offset (θ) and Azimuth (φ)”. Q is a quality factor. The inverse (or the reciprocal) of the quality factor (Q-1) is a measure of the attenuation of the seismic-wave energy. When analysing the azimuthal variation of attenuation, it is considered that a fractured reservoir can be represented as a model of a transversely isotropic medium with a horizontal axis of symmetry (HTI). We derive an updated QVOA method to achieve the highest accuracy in estimation of the fracture-strike angle. The method is based on a new formula for the Q-1(θ,φ)-attenuation function, which gives the highest accuracy in estimating the azimuth of fractures by the least-squares method (LSM). As a sought-for parameter, we consider the fractures’ azimuth (φ0). In the former version of QVOA method, we used a simplified approximation formula of the attenuation function in the form A + Bx + Cx2 (where x = sin2θ cos2(φ-φ0)), as well as its truncated approximation A + Bx. However, to achieve the highest accuracy in estimating fracture direction, it is best to use our new canonical formula of the attenuation function, which gives the best accuracy of 0.25 degrees, which is validated by simulated seismic data of physical modelling. To test our QVOA method we use seismic data simulated by ultrasonic experiment. An artificial sample of fractured rock is built in the form of a four-layer cake model, which is immersed in water. Inside this layer cake there is an insert with artificial vertical aligned cracks. The Q-data on the attenuation are estimated along three seismic lines with 3 azimuths of the source-receiver line, φ = 0°, φ = 45°, and φ = 90°. To estimate the fracture-strike φ0-azimuth, we use the least squares method (LSM), namely, we minimize the functional of the difference between the theoretical function Q-1(θ,φ) and the real attenuation estimated from seismic data. The canonical formula results in the smallest and the most stable error (compared to the older versions of QVOA-method). The maximal attenuation is obtained at the φ = 0°-azimuth, which is the direction orthogonal to the fracture strike; and the minimal attenuation is at the φ0 = 90°, which is the fracture-strike. Thus, the experiment fully confirms the QVOA-method.
Quality of life, functional impairment and healthcare experiences of patients with irritable bowel syndrome in Norway: An online survey
Authors: El-Salhy Magdy , Johansson Mads , Ekelund Miriam , Hatlebakk Jan Gunnar 
Published: March 2024

Abstract
Background: The present study is an online survey to determine the quality of life and functional impairment caused by irritable bowel syndrome (IBS) and the healthcare experiences of IBS patients in Norway, which has not been done previously.
Methods: An author-developed, online questionnaire using Microsoft Forms program was applied. The questionnaire comprised 52 questions. The questionnaire was posted from 1 March to 17 April (a 48-day period) on the Norwegian Gastrointestinal Association website and in its magazine and social media posts.
Results: The questionnaire was completed by 2727 patients. Of these patients 327 were excluded because they have not been diagnosed by a medical doctor. IBS reduced the quality of life in 97% of affected patients, including the social life in 90% and the sexual life in 69%. The unemployment rate of IBS patients in Norway was 29%, which is more than 8-fold higher than that of the general population, and 94% of IBS patients reported that IBS impaired their work/study performance. About half of the patients had to discuss their abdominal symptoms with their general practitioner (GP) more than 10 times and wait more than 1 years before being diagnosed. Only 34% and 48% were satisfied with the help they received from their GP and gastroenterologist, respectively. Only 18% and 43% of the IBS patients felt that their GP and gastroenterologist, respectively, were sufficiently knowledgeable about IBS. Only 21% of the IBS patients was satisfied with the treatment they received.
Conclusions: IBS markedly reduces the affected patient’s quality of life and their working productivity. IBS patients are generally dissatisfied with the clinical management they receive from GPs and gastroenterologists.
Changes in the outer nuclear layer and choroidal vascularity during the manifest and quiescent phases of acute central serous chorioretinopathy
Authors: Lim Gyeongsoo , Kim Kyung Tae , Kim Dong Yoon , Chae Ju Byung , Seo Eoi Jong 
Published: March 2024

Abstract
To investigate alteration of outer nuclear layer (ONL) and choroidal vascularity index (CVI) in different status of central serous chorioretinopathy (CSC). A retrospective review of 65 CSC eyes with subretinal fluid (manifest CSC) and 40 control eyes was conducted in a single tertiary university hospital. Differences in best-corrected visual acuity (BCVA), ONL, and CVI were compared. CVI was assessed both in the entire choroid (CVI-EC) and around the 1,500μm leakage area (CVI-1500). Measurements were repeated after the subretinal fluid resorption (quiescent CSC), and compared. CSC eyes showed worse BCVA, thinner ONL and greater CVI than controls. Quiescent CSC showed a recovery of ONL compared to the manifest CSC, along with the BCVA improvement. The resolution of the CSC revealed a decrease across all three choroidal areas (total, stromal and luminal), with a more pronounced reduction in the stromal than in the luminal choroidal area, leading to an increase in the CVI. This phenomenon was shown in both CVI-EC and CVI-1500. Conclusively, ONL thickness can be used as a quantitative biomarker for photoreceptor function in CSC. Increased CVI may reflect a disease activity. The stromal choroidal area is particularly sensitive in illustrating leakage from the choroidal vasculature.
Neuroprotective effects of arterial albumin in acute ischemic stroke with large vessel occlusion after endovascular therapy (NAIS-LVO): Rationale, design, and protocol for a prospective clinical trial
Authors: Du Kangjie , pan sihu , Liu Shuling , Wang Sifei , Luo Leilei , Xu Yongbo , Cao Chen , Chen Jian , Ji Xunming , Wei Ming 
Published: March 2024

Abstract
Background
Acute ischemic stroke (AIS) is an acute brain injury caused by sudden occlusion of a blood vessel, leading to interrupted blood flow. Endovascular therapy is the most effective way to restore blood flow. Although blood flow is restored in some patients, their clinical prognosis remains unsatisfactory. Albumin has shown neuroprotective effects in animal models of AIS through various mechanisms. Therefore, this study aims to evaluate the safety, feasibility, and efficacy of local arterial infusions of 20% human serum albumin solution as an adjuvant therapy after endovascular therapy in patients with AIS.
Methods
This is a prospective clinical trial for testing the use of 20% human serum albumin solution injected via the artery after thrombectomy in patients with AIS. The study is divided into two stages. The first stage will explore the maximum safe dose according to the 3 + 3 dose increment principle; seven dose groups will be set up, with the maximum dose being 0.60 g/kg. After recanalizing the occluded blood vessel, 20% human serum albumin solution will be injected into the internal carotid artery region through an arterial catheter for 30 min. The second stage involves including at least 15 additional participants to complete safety trials at the maximum safe dose determined in the first stage. The primary outcome of this study will be symptomatic intracranial hemorrhage. The secondary safety outcomes are death from any cause, intracranial hemorrhage, adverse reactions, severe adverse reactions, albumin-induced heart failure, pulmonary interstitial edema, and inflammatory anaphylaxis. The efficacy outcomes include the proportion of patients with a modified Rankin Scale of 0–2 on day 90 after randomization, the progression of cerebral infarction volume, and the National Institutes of Health Stroke Scale score after surgery.
Conclusion
This prospective clinical trial explores the safety and efficacy of arterial infusion of an albumin solution after occlusive vessel opening in AIS. The results will provide data parameters for subsequent tests on the arterial infusion of albumin solutions.
Trial registration number: ClinicalTrials.gov NCT05953623, registered on 20/07/2023.
Analysis of risk factors of postoperative complication for non-small cell lung cancer Sub-heading Risk factors of postoperative complication
Authors: Motono Nozomu , Mizoguchi Takaki , Ishikawa Masahito , Iwai Shun , Iijima Yoshihito , Uramoto Hidetaka 
Published: March 2024

Abstract
Background
The relationship between risk factors of common postoperative complications after pulmonary resection, such as air leakage, atelectasis, and arrhythmia, and patient characteristics, including nutritional status or perioperative factors, has not been sufficiently elucidated.
Methods
One thousand one hundred thirty-nine non-small cell lung cancer patients who underwent pulmonary resection were retrospectively analyzed for risk factors of common postoperative complications.
Results
In a multivariate analysis, male sex (P = 0.01), age ≥ 65 years (P < 0.01), coexistence of chronic obstructive pulmonary disease (COPD) (P < 0.01), upper lobe (P < 0.01), surgery time ≥ 155 minutes (P < 0.01), and presence of lymphatic invasion (P = 0.01) were significant factors for postoperative complication. Male sex (P < 0.01), age ≥ 65 years (P = 0.02), body mass index (BMI) < 21.68 (P < 0.01), coexistence of COPD (P = 0.02), and surgery time ≥ 155 minutes (P = 0.01) were significant factors for severe postoperative complication. Male sex (P = 0.01), BMI < 21.68 (P < 0.01), thoracoscopic surgery (P < 0.01), and surgery time ≥ 155 minutes (P < 0.01) were significant risk factors for postoperative air leakage. Coexistence of COPD (P = 0.01) and coexistence of asthma (P < 0.01) were significant risk factors for postoperative atelectasis. Prognostic nutrition index (PNI) < 45.52 (P < 0.01), lobectomy or extended resection more than lobectomy (P = 0.01), and surgery time ≥ 155 minutes (P < 0.01) were significant risk factors for postoperative arrhythmia.
Conclusion
Low BMI, thoracoscopic surgery, and longer surgery time were significant risk factors for postoperative air leakage. Coexistence of COPD and coexistence of asthma were significant risk factors for postoperative atelectasis. PNI, surgery time, and surgical procedure were revealed as risk factors of postoperative arrhythmia. Patients with these factors should be monitored for postoperative complication.
Trial registration:
The Institutional Review Board of Kanazawa Medical University approved the protocol of this retrospective study (approval number: I392), and written informed consent was obtained from all patients