bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the impact of MiR-92a-3p on FOLFOX chemoresistance biomarker genes in colon cancer cell lines
Authors: Escalante Paula I. , Quiñones Luis A. , Contreras Héctor R. 
Published: April 2024

Introduction: One of the primary obstacles faced by individuals with advanced colorectal cancer (CRC) is the potential development of acquired chemoresistance as the disease advances. Studies have indicated a direct association between elevated levels of miR-92a-3p and the progression, metastasis, and chemoresistance observed in CRC. We proposed that miR-92a-3p impairs FOLFOX (fluorouracil/oxaliplatin) chemotherapy response by upregulating the expression of chemoresistance biomarker genes through the activation of β-catenin and epithelial-mesenchymal transition (EMT). These FOLFOX biomarker genes include the pyrimidine biosynthesis pathway genes dihydropyrimidine dehydrogenase (DPYD), thymidylate synthase (TYMS), methylenetetrahydrofolate reductase (MTHFR), and the genes encoding the DNA repair complexes subunits ERCC1 and ERCC2, and XRCC1.Methods: To assess this, we transfected SW480 and SW620 colon cancer cell lines with miR-92a-3p mimics and then quantified the expression of DPYD, TYMS, MTHFR, ERCC1, ERCC2, and XRCC1, the expression of EMT markers and transcription factors, and activation of β-catenin.Results and discussion: Our results reveal that miR-92a-3p does not affect the expression of DPYD, TYMS, MTHFR, and ERCC1. Furthermore, even though miR-92a-3p affects ERCC2, XRCC1, E-cadherin, and β-catenin mRNA levels, it has no influence on their protein expression.Conclusion: We found that miR-92a-3p does not upregulate the expression of proteins of DNA-repair pathways and other genes involved in FOLFOX chemotherapy resistance.
Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy
Authors: Coleman James A. , Doste Ruben , Beltrami Matteo , Argirò Alessia , Coppini Raffaele , Olivotto Iacopo , Raman Betty , Bueno-Orovio Alfonso 
Published: April 2024

Introduction: Hypertrophic cardiomyopathy (HCM) is a leading cause of lethal arrhythmias in the young. Although the arrhythmic substrate has been hypothesised to be amenable to late Na+ block with ranolazine, the specific mechanisms are not fully understood. Therefore, this study aimed to investigate the substrate mechanisms of safety and antiarrhythmic efficacy of ranolazine in HCM.Methods: Computational models of human tissue and ventricles were used to simulate the electrophysiological behaviour of diseased HCM myocardium for variable degrees of repolarisation impairment, validated against in vitro and clinical recordings. S1-S2 pacing protocols were used to quantify arrhythmic risk in scenarios of (i) untreated HCM-remodelled myocardium and (ii) myocardium treated with 3µM, 6µM and 10µM ranolazine, for variable repolarisation heterogeneity sizes and pacing rates. ECGs were derived from biventricular simulations to identify ECG biomarkers linked to antiarrhythmic effects.Results: 10µM ranolazine given to models manifesting ventricular tachycardia (VT) at baseline led to a 40% reduction in number of VT episodes on pooled analysis of &gt;40,000 re-entry inducibility simulations. Antiarrhythmic efficacy and safety were dependent on the degree of repolarisation impairment, with optimal benefit in models with maximum JTc interval &lt;370 ms. Ranolazine increased risk of VT only in models with severe-extreme repolarisation impairment.Conclusion: Ranolazine efficacy and safety may be critically dependent upon the degree of repolarisation impairment in HCM. For moderate repolarisation impairment, reductions in refractoriness heterogeneity by ranolazine may prevent conduction blocks and re-entry. With severe-extreme disease substrates, reductions of the refractory period can increase re-entry sustainability.
Reading comprehension differences between children with Autism Spectrum Disorder and low cognitive abilities and children with Autism Spectrum Disorder and intact cognitive skills: the roles of decoding, fluency and morphosyntax
Authors: Peristeri Eleni , Frantzidis Christos A. , Andreou Maria 
Published: April 2024

IntroductionReading comprehension is one of the most important skills learned in school and it has an important contribution to the academic success of children with Autism Spectrum Disorder (ASD). Though previous studies have investigated reading comprehension difficulties in ASD and highlighted factors that contribute to these difficulties, this evidence has mainly stemmed from children with ASD and intact cognitive skills. Also, much emphasis has been placed on the relation between reading comprehension and word recognition skills, while the role of other skills, including fluency and morphosyntax, remains underexplored. This study addresses these gaps by investigating reading comprehension in two groups of school-aged children with ASD, one with intact and one with low cognitive abilities, also exploring the roles of word decoding, fluency and morphosyntax in each group’s reading comprehension performance.MethodsThe study recruited 16 children with ASD and low cognitive abilities, and 22 age-matched children with ASD and intact cognitive skills. The children were assessed on four reading subdomains, namely, decoding, fluency, morphosyntax, and reading comprehension.ResultsThe children with ASD and low cognitive abilities scored significantly lower than their peers with intact cognitive abilities in all reading subdomains, except for decoding, verb production and compound word formation. Regression analyses showed that reading comprehension in the group with ASD and intact cognitive abilities was independently driven by their decoding and fluency skills, and to a lesser extent, by morphosyntax. On the other hand, the children with ASD and low cognitive abilities mainly drew on their decoding, and to a lesser extent, their morphosyntactic skills to perform in reading comprehension.DiscussionThe results suggest that reading comprehension was more strongly affected in the children with ASD and low cognitive abilities as compared to those with intact cognitive skills. About half of the children with ASD and intact cognitive skills also exhibited mild-to-moderate reading comprehension difficulties, further implying that ASD may influence reading comprehension regardless of cognitive functioning. Finally, strengths in decoding seemed to predominantly drive cognitively-impaired children’s reading performance, while the group with ASD and intact cognitive skills mainly recruited fluency and metalinguistic lexical skills to cope with reading comprehension demands, further suggesting that metalinguistic awareness may be a viable way to enhance reading comprehension in ASD.
The impact of virtual reality on student engagement in the classroom–a critical review of the literature
Authors: Lin Xiao Ping , Li Bin Bin , Yao Zhen Ning , Yang Zhi , Zhang Mingshu 
Published: April 2024

ObjectiveThe purpose of this review is to identify the impact of virtual reality (VR) technology on student engagement, specifically cognitive engagement, behavioral engagement, and affective engagement.MethodsA comprehensive search of databases such as Google, Scopus, and Elsevier was conducted to identify English-language articles related to VR and classroom engagement for the period from 2014 to 2023. After systematic screening, 33 articles were finally reviewed.ResultsThe use of VR in the classroom is expected to improve student engagement and learning outcomes, and is particularly effective for students with learning disabilities. However, introducing VR into middle school education poses several challenges, including difficulties in the education system to keep up with VR developments, increased demands on students’ digital literacy, and insufficient proficiency of teachers in using VR.ConclusionTo effectively utilize VR to increase student engagement, we advocate for educational policymakers to provide training and technical support to teachers to ensure that they can fully master and integrate VR to increase student engagement and instructional effectiveness.
Measles outbreak investigation in Tocha district, southwestern Ethiopia: an unmatched case–control study
Authors: Tefera Simon Fikadu , Admasu Nigatu , Abebe Habtamu , Feyisa Gemechu Chemeda , Midaksa Gachana 
Published: April 2024

BackgroundMeasles continues to be a public health challenge in Ethiopia. Rumors of suspected measles were notified on April 8, 2023 from Tocha district. We conducted an assessment to describe measles outbreak and determine risk factors for measles infection in the Tocha district of the Dawuro zone, Southwest Ethiopia.MethodsWe conducted a 1:2 unmatched case–control studies from April to May 2023. We took all 147 cases registered on line list for descriptive analyses. We used a total of 74 randomly selected cases and 147 controls for case–control part. Any person in Tocha district with laboratory-confirmed measles IgM antibody; or any suspected person epidemiologically linked to confirmed measles cases from March 23 to April 26 2023, were included in the case. Neighborhood who did not fulfill this standard case definition were included in controls. Data were collected using standardized questionnaires deployed on Kobo Collect. Descriptive analyses were conducted using Epi info version 7.2.5.0. The analyses were performed using Statistical Package for Social Science (SPSS) version 26. Binary logistic regression analyses were utilized to select candidate variables. We conducted multiple logistic regression analysis to identify determinants of measles infection at a p value ≤0.05 with 95% confidence interval.ResultsThe overall attack rate of 22.64/10,000 for general population and 104.59/10,000 among under-five children were attributed to the outbreak with a case fatality rate of 2.72%. Vaccine coverage in the last year and this year were 73.52 and 53.88%, respectively, while vaccine effectiveness in the district was 79%. Poor house ventilation (AOR = 3.540, 95% CI: 1.663–7.535) and having contact history with the case (AOR = 2.528, 95% CI: 1.180–4.557) were positively related to measles infection while being previously vaccinated for measles (AOR = 0.209, 95% CI: 0.180–4.577) reduce risk of measles infections.ConclusionThe highest attack rate was observed among children under 5 years of age, with a case fatality rate of 2.72%. Vaccination coverage was less than what expected to develop herd immunity. Strategies to increase vaccination coverage and strengthening surveillance systems for rumor identification and early responses to prevent person to person transmission are recommended.
Screening for social determinants of health among populations at risk for MASLD: a scoping review
Authors: Kim Rebecca G. , Ballantyne April , Conroy Molly B. , Price Jennifer C. , Inadomi John M. 
Published: April 2024

BackgroundSocial determinants of health (SDoH) have been associated with disparate outcomes among those with metabolic dysfunction-associated steatotic liver disease (MASLD) and its risk factors. To address SDoH among this population, real-time SDoH screening in clinical settings is required, yet optimal screening methods are unclear. We performed a scoping review to describe the current literature on SDoH screening conducted in the clinical setting among individuals with MASLD and MASLD risk factors.MethodsThrough a systematic literature search of MEDLINE, Embase, and CINAHL Complete databases through 7/2023, we identified studies with clinic-based SDoH screening among individuals with or at risk for MASLD that reported pertinent clinical outcomes including change in MASLD risk factors like diabetes and hypertension.ResultsTen studies (8 manuscripts, 2 abstracts) met inclusion criteria involving 148,151 patients: 89,408 with diabetes and 25,539 with hypertension. Screening was primarily completed in primary care clinics, and a variety of screening tools were used. The most commonly collected SDoH were financial stability, healthcare access, food insecurity and transportation. Associations between clinical outcomes and SDoH varied; overall, higher SDoH burden was associated with poorer outcomes including elevated blood pressure and hemoglobin A1c.ConclusionDespite numerous epidemiologic studies showing associations between clinical outcomes and SDoH, and guidelines recommending SDoH screening, few studies describe in-clinic SDoH screening among individuals with MASLD risk factors and none among patients with MASLD. Future research should prioritize real-time, comprehensive assessments of SDoH, particularly among patients at risk for and with MASLD, to mitigate disease progression and reduce MASLD health disparities.
The relationship between psychological capital, burnout and perceived stress in junior nurses: a latent profile analysis
Authors: Zhang Xu , Chen Siye , Zheng Ziling , Zhao Mi , Song Li , Zhao Yue , Wang Zhiwen 
Published: April 2024

BackgroundPsychological capital, an intrinsic personal asset, enhances junior nurses’ ability to navigate transition and sustain superior job performance. This study aimed to classify junior nurses into distinct psychological capital profiles and examine their associations with burnout and perceived stress levels.MethodsA cross-sectional study involving 480 junior nurses from three hospitals in Beijing assessed psychological capital, stress, and burnout using e-questionnaires, from July 2021 to August 2022. We employed exploratory latent profile analysis for psychological capital profiling and logistic regression with the best subset method to identify the influential factors.ResultsThe results of the latent profile analysis supported the models of two latent profiles, which were defined as low psychological capital (224, 46.5%) and high psychological capital (256, 53.5%). Logistic regression revealed that introverted nurses and those experiencing moderate to high levels of burnout and stress were more likely to exhibit low psychological capital.ConclusionNursing management should proactively identify and support junior nurses with low psychological capital, with a focus on introverted individuals, to mitigate the impact of stress and burnout.
North Macedonia interprofessional dementia care (NOMAD) – personalized care plans for people with dementia and caregiver psychoeducation delivered at home by interprofessional teams
Authors: Novotni Gabriela , Taneska Marija , Novotni Antoni , Fischer Julia , Iloski Svetlana , Ivanovska Andrea , Dimitrova Vesna , Novotni Ljubisha , Milutinović Miloš , Joksimoski Boban , Chorbev Ivan , Hasani Shpresa , Dogan Vildan , Grimmer Timo , Kurz Alexander 
Published: April 2024

IntroductionThe increasing number of people living with dementia and its burden on families and systems particularly in low- and middle-income countries require comprehensive and efficient post-diagnostic management. This study aimed to explore the acceptability and efficacy of a multi-professional case management and psychoeducation model (North Macedonia Interprofessional Dementia Care, or NOMAD) delivered by mobile teams for people with dementia and their caregivers in North Macedonia.MethodWe conducted a two-arm randomized controlled trial comparing the intervention with treatment as usual. Participants were recruited from 12 general practitioner (GP) offices in the Skopje region. The NOMAD intervention included the delivery of a personalized care plan over four home visits to dyads of people with dementia and their caregivers by a team including a dementia nurse and a social worker, in collaboration with GPs and dementia experts, and the introduction of a caregiver manual. We assessed caregivers' depressive symptoms, burden, and quality of life and the neuropsychiatric symptoms, daily living activities, and service utilization of people with dementia at baseline and follow-up; we also assessed the acceptability of the intervention by analyzing case notes and attendance rates.ResultsOne hundred and twenty dyads were recruited and randomized to either the control (n = 60) or the intervention group (n = 60). At follow-up, caregivers in the intervention group had, on average, scores that were 2.69 lower for depressive symptoms (95% CI [−4.75, −0.62], p = 0.012), and people with dementia had, on average, 11.32 fewer neuropsychiatric symptoms (95% CI [−19.74, −2.90], p = 0.009) and used, on average, 1.81 fewer healthcare services (95% CI [−2.61, −1.00], p &lt; 0.001) compared to the control group. The completion of the home visits was 100%, but the intervention's acceptability was underpinned by relationship building, GP competencies, and resources to support families with dementia. There were no differences in the caregivers' quality of life and burden levels or daily living activities in people with dementia. NOMAD is the first case management, non-pharmacological, and multi-professional intervention tested in North Macedonia.DiscussionThe trial showed that it is effective in reducing caregivers' depressive symptoms and neuropsychiatric symptoms in people with dementia and the burden on health and social care services, and it is acceptable for families. Implementing NOMAD in practice will require building primary care capacity and recognizing dementia as a national priority.
Individualized management of chronic periodontitis in patients with orthodontic abnormalities: a clinical case report
Authors: Blashkova S. L. , Fazylova Y. V. , Shaidullin I. M. , Urdyakov I. Z. 
Published: April 2024

Relevance. Chronic periodontitis is a multifactorial disease influenced by a variety of factors. Beyond periodontal pathogens and systemic conditions, important contributing factors include malocclusion, dental misalignment, and tooth loss. These conditions can compromise the tissue blood flow hemodynamics and precipitate occlusal trauma with signs of functional overload. Subsequently, this may intensify the inflammation and degradation of the alveolar bone, often leading to premature tooth loss.Correction of malocclusion is paramount in the effective management of periodontal diseases, requiring orthodontic treatment to resolve malocclusion and mitigate signs of functional overload. This treatment aims to redistribute occlusal forces uniformly, thus creating a conducive environment for successful prosthodontic rehabilitation and promoting optimal personal oral hygiene.Clinical case description. This article outlines a personalized approach to managing periodontal inflammation in individuals with orthodontic anomalies. Patient Z., born in 2002, was diagnosed with moderate severity chronic periodontitis (K05.31), presenting with a Class I molar and canine relationship on both sides, constricted dental arches, individual tooth macrodontia, and retrusion and torsiversion of the incisors. The assessment of the patient's periodontal status and overall health was conducted using standard clinical, radiographic, and laboratory diagnostics, whereas the orthodontic assessment involved anthropometric analysis of dental casts and lateral cephalometric radiographs. The periodontal intervention included foundational non-surgical treatments such as ultrasonic scaling both supra- and subgingivally, biofilm disruption using the Vector Paro system, and specific pharmacotherapy. The orthodontic treatment aimed to widen both dental arches and correct the inclination of the upper and lower incisors, achieving a normal occlusion with fixed orthodontic appliances (Damon Q brackets) in accordance with the treatment plan. The effectiveness of the treatment was measured by examining the improvement in gingival conditions, periodontal parameters, and radiographic evidence before and after the intervention.Conclusion. The research demonstrated that an individualized treatment protocol integrating periodontal and orthodontic care can substantially improve the overall health of the dentofacial complex, masticatory efficiency, and aesthetic aspects.
Les éducations à… : ya basta !
Authors: Beitone Alain , Hemdane Estelle 
Published: April 2024

Les « éducations à », apparues dans les années 1970, ont pris leur essor dans les années 2000 avec l’ambition non dissimulée de transformer l’école et les pratiques enseignantes. Dans cet article, nous décrivons la contestation des savoirs et des disciplines scolaires qui les sous-tendent sur fond d’exaltation de la post-modernité et de relativisme. Nous soulignons les limites épistémologiques et pédagogiques de ces enseignements et faisons l’hypothèse qu’elles expliquent pourquoi les enseignants et l’institution semblent s’en détourner aujourd’hui.
Contenus, configurations et conscience disciplinaires
Authors: Reuter Yves 
Published: April 2024

Après avoir présenté les concepts de contenu scolaire et de configuration disciplinaire, essentiels dans la perspective didactique qui est la sienne, Yves Reuter définit le concept de conscience disciplinaire au travers de ses composantes (forme, clarté et pertinence) et de ses principaux intérêts : mieux comprendre l’opacité pour un certain nombre d’élèves des organisations disciplinaires, éclairer autrement les relations à l’échec scolaire, appréhender les relations entre contenus et conscience disciplinaire, éclairer des pistes d’intervention possibles dans les classes. Ainsi construite, la conscience disciplinaire apparaît non seulement comme un contenu d’apprentissage, mais aussi et surtout comme un cadre d’intégration des contenus proposés.
« Qu’attend-on de moi ? » Le curriculum invisible, ce que l’école française n’enseigne pas
Authors: Netter Julien 
Published: April 2024

Pour mieux comprendre l’ampleur des inégalités scolaires qui caractérise le système éducatif français, cet article approfondit une piste ouverte par Pierre Bourdieu et Jean-Claude Passeron dans les années 1960 en s’interrogeant sur ce que l’école n’enseigne pas, mais qui est nécessaire pour y apprendre. C’est ainsi une nouvelle forme du curriculum, le curriculum invisible, qui est proposée pour enrichir le tableau entrepris par la sociologie du curriculum. Les manifestations du curriculum invisible sont nombreuses et variées, mais difficiles à saisir pour des adultes à qui elles apparaissent « naturelles ». Pour mieux le faire percevoir, l’article développe plusieurs situations où il intervient. Puis il entreprend d’en décrire la teneur en insistant sur quatre propriétés majeures du curriculum invisible : l’appui sur des systèmes de signes, l’intrication de différentes dimensions à travers lesquelles il est susceptible de se manifester dans une même situation, l’articulation de ces différentes dimensions qui les rend difficilement discernables et enfin le domaine d’application du curriculum invisible, qui déborde des frontières de l’école.
Les savoirs scolaires : réalités et fictions
Authors: Chartier Anne-Marie 
Published: April 2024

L’article distingue les savoirs académiques et les disciplines scolaires, l’intitulé (spécialisé) des disciplines et les modalités (mixtes) d’enseignement (en France, lettres et littérature, histoire-géographie, SVT, etc.). Entre un imaginaire des savoirs (bien figuré par l’arbre de la connaissance des encyclopédistes) et l’exercice professionnel, la « spécialité » des professeurs constitue à la fois une identité et une culture, cumulant les savoirs à enseigner et des savoirs pour enseigner (sociologie, didactiques, psychologie, etc.). Les novices sont ainsi pris entre les discours prônant les situations pédagogiques ouvertes et les exercices standards fournis par une ingénierie didactique en phase avec les politiques d’évaluation. Ce souci d’école efficace laisse dans l’ombre tous les « savoirs d’élèves » construits dans une expérience singulière de l’école, lieu de vie sociale imprévisible autant que lieu d’apprentissages programmés.