bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strode's Longer Elegy
Authors: Morris Harry 
Published: April 2006

On Mistress Mary Prideaux: Epitaph 1-8Happy Grave, thou dost enshrineThat which makes thee a rich mine:Remember yet, ‘tis but a loane;And wee must have it back, Her owne,The very same; Marke mee, the same:Thou canst not cheat us with a lameDeformed Carcase; Shee was fayre,Fresh as Morning, sweete as Ayre.Bishop Henry King and Canon William Strode seem to have been handled similarly by fate until 1921, when in his essay on the metaphysical poets T. S. Eliot stimulated poetic interest in King by admiring an extended ‘journey’ metaphor that took up only a small portion of ‘The Exequy’. I wonder if something can be done for Strode. In several ways these poets are alike, and for both, their finest work can be found in the elegy.
A Note on Wyatt and Serafino D'Aquilano
Authors: Endicott Annabel M. 
Published: April 2006

Among the poems edited by Professor Kenneth Muir from the Blage manuscript of early Tudor poetry there appears the following octave (XXXIX):Thou slepest ffast; and I with woffull hartStand here alone, syghing, and cannot ffleye.Thou slepyst ffast, when crewell love his darteOn me dothe cast, Alas! so paynefullye.Thou slepyst fast, and I all ffull of smartTo the my fo in vayn do call and crye.And yet methinkes, thou that slepyst ffast,Thou dremyst styll whiche way my lyf to wast.This poem had previously appeared as anonymous in Norman Ault's Elizabethan Lyrics, and Professor Muir does not definitely ascribe it to Wyatt, in spite of the evidence of the verse form. Wyatt was the only early Tudor poet who thoroughly explored the possibilities of the Italian ottava.
Les Chefs Indigènes au Mayombe. Hier. Aujourd'hui. Demain
Authors: de Cleene N. 
Published: April 2006

Dans l'état présent de nos informations ethnographiques, deux migrations sont à considérer au Mayombe: celle des Basundi, à laquelle aurait succédé à une époque déjà plus rapprochée celle des Bakongo.Les premiers seraient originaires de la région des Manianga. Leurs légendes non seulement parlent d'un roi Makoko qui aurait regné à Muembe-Tsundi, elles rappellent aussi que Matsundi Nzila, après avoir erré au nord de la Tshiloango, aurait conduit les émigrants Tsundi dans la partie septentrionale du Mayombe belge actuel, où il se serait établi à Nganda-Tsundi. De là certaines fractions du groupe auraient gagné la basse Lubuzi, d'autres plus nombreuses se seraient dirigées vers le sud-est de la région.
Neighbour manipulations in natural vegetation a review
Authors: Aarssen L. W. , Epp G. A. 
Published: April 2006

Abstract. This paper reviews the literature on neighbour manipulation experiments on species intemctions in natural of semi‐natural vegetation. Three major approaches have been used: 1) introductions into vegetation, 2) trenching, and 3) vegetation removals. Some studies have used a combination of approaches, especially 1) and 3). The removal approach has been used most commonly and is given the greatest emphasis in this paper accordingly.Details of over 50 such studies are summarized here, 48 of which have appeared within only the last two decades. We compare and contrast the experimental designs of these studies and examine their contributions to the understanding of species interactions in vegetation. Evidence for competition is virtually universal among these studies. Several studies have also detected evidence of beneficence between plant species. Numerous factors may confound interpretations in removal experiments including: life stage dependent species responses, species‐dependent timing and speed of response, inadequacy of controls due to temporal and/or spatial variability in site quality, indirect effects of treatment on soil moisture content or nutrient levels, or on the activities of predators or decomposers, and several constraints inherent in particular experimental designs. Another level of complexity arises as a consequence of several variables related to plant attributes that directly determine the nature of interactions between neighbours (e.g. relative competitive abilities, the magnitude of beneficial interactions, the extent to which neighbours make demands on the same resource units). These may interact in a complex manner to affect the response of a ‘target’ plant to the removal of neighbours. Recommendations for future studies are considered and a neighbourhood experimental design is proposed which enables analysis of the extent to which the fates of naturally established individuals following vegetation removal can be accounted for (in multiple regressions) by several variables that reflect different properties and circumstances of interaction with immediate Thiessen neighbours in the field.
Factors Associated With Racial and Ethnic Disparities in Locally Advanced Rectal Cancer Outcomes
Authors: Shulman Rebecca M. , Deng Mengying , Handorf Elizabeth A. , Meyer Joshua E. , Lynch Shannon M. , Arora Sanjeevani 
Published: February 2024

ImportanceHispanic and non-Hispanic Black patients receiving neoadjuvant therapy and surgery for locally advanced rectal cancer (LARC) achieve less favorable clinical outcomes than non-Hispanic White patients, but the source of this disparity is incompletely understood.ObjectiveTo assess whether racial and ethnic disparities in treatment outcomes among patients with LARC could be accounted for by social determinants of health and demographic, clinical, and pathologic factors known to be associated with treatment response.Design, Setting, and ParticipantsThe National Cancer Database was interrogated to identify patients with T3 to T4 or N1 to N2 LARC treated with neoadjuvant therapy and surgery. Patients were diagnosed between January 1, 2004, and December 31, 2017. Data were culled from the National Cancer Database from July 1, 2022, through December 31, 2023.ExposureNeoadjuvant therapy for rectal cancer followed by surgical resection.Main Outcomes and MeasuresThe primary outcome was the rate of pathologic complete response (pCR) following neoadjuvant therapy. Secondary outcomes were rate of tumor downstaging and achievement of pN0 status.ResultsA total of 34 500 patient records were reviewed; 21 679 of the patients (62.8%) were men and 12 821 (37.2%) were women. The mean (SD) age at diagnosis was 59.7 (12.0) years. In terms of race and ethnicity, 2217 patients (6.4%) were Hispanic, 2843 (8.2%) were non-Hispanic Black, and 29 440 (85.3%) were non-Hispanic White. Hispanic patients achieved tumor downstaging (48.9% vs 51.8%; P = .01) and pN0 status (66.8% vs 68.8%; P = .02) less often than non-Hispanic White patients. Non-Hispanic Black race, but not Hispanic ethnicity, was associated with less tumor downstaging (odds ratio [OR], 0.86 [95% CI, 0.78-0.94]), less frequent pN0 status (OR, 0.91 [95% CI, 0.83-0.99]), and less frequent pCR (OR, 0.81 [95% CI, 0.72-0.92]). Other factors associated with reduced rate of pCR included rural location (OR, 0.80 [95% CI, 0.69-0.93]), lack of or inadequate insurance (OR for Medicaid, 0.86 [95% CI, 0.76-0.98]; OR for no insurance, 0.65 [95% CI, 0.54-0.78]), and treatment in a low-volume center (OR for first quartile, 0.73 [95% CI, 0.62-0.87]; OR for second quartile, 0.79 [95% CI, 0.70-0.90]; OR for third quartile, 0.86 [95% CI, 0.78-0.94]). Clinical and pathologic variables associated with a decreased pCR included higher tumor grade (OR, 0.58 [95% CI, 0.49-0.70]), advanced tumor stage (OR for T3, 0.56 [95% CI, 0.42-0.76]; OR for T4, 0.30 [95% CI, 0.22-0.42]), and lymph node–positive disease (OR for N1, 0.83 [95% CI, 0.77-0.89]; OR for N2, 0.73 [95% CI, 0.65-0.82]).Conclusions and RelevanceThe findings of this cohort study suggest that disparate treatment outcomes for Hispanic and non-Hispanic Black patients are likely multifactorial in origin. Future investigation into additional social determinants of health and biological variables is warranted.
Growth Hormone Mediators and Glycemic Control in Youths With Type 2 Diabetes
Authors: Lu Chang , Wolfs Danielle , El ghormli Laure , Levitsky Lynne L. , Levitt Katz Lorraine E. , Laffel Lori M. , Patti Mary-Elizabeth , Isganaitis Elvira 
Published: February 2024

ImportanceYouth-onset type 2 diabetes (T2D) has a more aggressive phenotype than adult-onset T2D, including rapid loss of glycemic control and increased complication risk.ObjectiveTo identify associations of growth hormone mediators with glycemic failure, beta cell function, and insulin sensitivity in youth-onset T2D.Design, Setting, and ParticipantsThis post hoc secondary analysis of the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) randomized clinical trial, which enrolled participants from July 2004 to February 2009, included 398 participants from 15 university-affiliated medical centers with available plasma samples from baseline and 36 months. Participants were youths aged 10 to 17 years with a duration of T2D of less than 2 years who were randomized to metformin, metformin plus lifestyle intervention, or metformin plus rosiglitazone. Participants were followed up for a mean (SD) of 3.9 (1.5) years during the trial, ending in 2011. Statistical analysis was performed from August 2022 to November 2023.ExposurePlasma insulin-like growth factor-1 (IGF-1), growth hormone receptor (GHR), and insulin-like growth factor binding protein 1 (IGFBP-1).Main Outcomes and MeasuresMain outcomes were (1) loss of glycemic control during the TODAY study, defined as hemoglobin A1c (HbA1c) level of 8% or more for 6 months or inability to wean from insulin therapy, and (2) baseline and 36-month measures of glycemia (fasting glucose, HbA1c), insulin sensitivity (1/fasting C-peptide), high-molecular-weight adiponectin, and beta cell function (C-peptide index, C-peptide oral disposition index).ResultsThis analysis included 398 participants (mean [SD] age, 13.9 [2.0] years; 248 girls [62%]; 166 Hispanic participants [42%]; 134 non-Hispanic Black participants [34%], and 84 non-Hispanic White participants [21%]). A greater increase in IGF-1 level between baseline and 36 months was associated with lower odds of glycemic failure (odds ratio [OR], 0.995 [95% CI, 0.991-0.997]; P &amp;lt; .001) and higher C-peptide index per 100-ng/mL increase in IGF-1 (β [SE], 0.015 [0.003]; P &amp;lt; .001). A greater increase in log2 GHR level between baseline and 36 months was associated with higher odds of glycemic failure (OR, 1.75 [95% CI, 1.05-2.99]; P = .04) and lower C-peptide index (β [SE], −0.02 [0.006]; P &amp;lt; .001). A greater increase in log2 IGFBP-1 level between baseline and 36 months was associated with higher odds of glycemic failure (OR, 1.37 [95% CI, 1.09-1.74]; P = .007) and higher high-molecular-weight adiponectin (β [SE], 431 [156]; P = .007).Conclusions and RelevanceThis study suggests that changes in plasma growth hormone mediators are associated with loss of glycemic control in youth-onset T2D, with IGF-1 associated with lower risk and GHR and IGFBP-1 associated with increased risk.Trial RegistrationClinicalTrials.gov Identifier: NCT00081328
SiO2‑g‑Polyisoprene Particle Brush Reinforced Advanced Elastomer Nanocomposites Prepared via ARGET ATRP
Authors: Liu Yingxue , Wang Zongyu , Zhao Yuqi , Hou Guanyi , Jiang Ruifeng , Bockstaller Michael R. , Qin Xuan , Zhang Liqun , Matyjaszewski Krzysztof 
Published: February 2024

AbstractNanoparticle reinforcement is a general approach toward the strengthening of elastomer nanocomposite in large‐scale applications. Extensive studies and efforts have been contributed to demonstrating the property reinforcement of polymer nanocomposites in relation to matrix‐filler and filler‐filler interaction. Here, a facile synthetic method is creatively reported to synthesize SiO2,15/120‐g‐polyisoprene (SiO2‐g‐PI) particle brushes using atom transfer radical polymerization (ATRP). The dispersion and microstructures of the nanoparticles in the nanocomposites are investigated by morphological characterizations, whereas the reinforcing mechanism is studied through mechanical measurements as well as computational simulation. Remarkably, compared with the cured bulk elastomers and matrix(M)/SiO2 blends, M/particle brushes (PB) exhibit significant improvement in mechanical properties, including tensile strength, elongation at break, modules, and rolling resistance. This elastomer nanocomposites afford a novel prospect for the practical application of next‐generation automobile tires with enhanced performance.
Superspreading‐Confined Assembly of Oriented 2D MOF Membranes for Biomimetic Cation‐Regulated Ion Transport
Authors: Qiu Ming , Zhu Zhongpeng , Wang Dianyu , Xu Zhe , Xia Fan , Jiang Lei , Tian Ye 
Published: February 2024

AbstractInspired by biological channels, metal‐organic framework (MOF) membranes with sub‐nanometer sized channels offer an ideal platform to construct high‐performance artificial nanofluidic system. However, fabricating long‐range ordered MOF membranes is still a significant challenge. Herein, a superspreading‐confined assembly method is developed to prepare large‐scale oriented 2D MOF (Zn‐TCPP (TCPP = meso‐tetra(4‐carboxyphenyl) porphine)) membranes. The superspreading of reactant liquid under oil phase to form liquid layer plays a critical role in membrane formation, which provides a dynamic confined space for layered assembly of Zn‐TCPP nanosheets. Accompanied with solvent diffusion, such liquid layer is completely converted into <001>‐oriented MOF membrane with controlled thickness. The prepared membrane exhibits distinct divalent cation (Mx2+)‐regulated ion transport behavior as that demonstrated in biological channels: K+ flux can be precisely adjusted by anchoring diverse Mx2+ ions to binding sites, which is appealing in designing high‐performance nanofluidic iontronics. Moreover, similar strategies can be employed to fabricate other MOF membranes (such as Hf‐BTB (BTB = 1,3,5‐tris(4‐carboxyphenyl)benzene) and Ni‐TCPE (TCPE = tetrakis(4‐carboxyphenyl)ethylene)), indicating the broad applicability of this method in 2D membrane fabrication.
Bio‐Functional Hydrogel Microspheres for Musculoskeletal Regeneration
Authors: Yang Jielai , Xia Pengfei , Meng Fanshu , Li Xingchen , Xu Xiangyang 
Published: February 2024

AbstractThe worldwide prevalence of musculoskeletal disorders is expected to rise due to an accelerating aging population and increasing associated factors. Despite the high rate of disability induction, clinical options for the treatment of musculoskeletal disorders remain limited. Hydrogel microspheres (HMSs), which are colloidal particles with crosslinked polymer networks at the nanometer scale, are characterized by excellent biocompatibility, easy‐to‐tune structures (e.g., stiffness, porosity, and composition), and high encapsulation efficiency of therapeutic agents (e.g., drugs and cells). At present, multiple techniques are utilized for the fabrication of HMSs and encapsulation of therapeutic agents. The HMSs can be produced and used in different states to match specific utilizations. These desirable properties, along with their injectability, bestow HMSs with mutifunctionalities that can be utilized for a variety of biomedical applications (e.g., delivery of biologics, tissue regeneration, and bio‐lubrication), and thus enable them to be promising tools for tackling a variety of clinical diseases. Herein, the focus is the fabrication and application of therapeutic HMSs for i) bone disorders, ii) cartilage and osteochondral disorders, iii) intervertebral disc (IVD) disorders, and iv) neurovascular disorders, with the aim of overviewing the recent progress to summarize key contributions and findings and highlight the limitations and opportunities in this field.
Observing Weak Interchain Coupling in 1D vdWs Ternary Mo6Se2I8 to Achieve Probe Exfoliation of Ultrathin Molecular Chains
Authors: Guan Yanchao , Ding Ye , Fang Yuqiang , Zhou Fei , Wang Jiapeng , Li Xinyu , Zhao Shouxin , Gao Bo , Xu Chengyan , Zhen Liang , Huang Fuqiang , Yang Lijun , Li Yang 
Published: February 2024

Abstractvan der Waals (vdWs) interchain coupling is a unique feature of 1D vdWs materials, where strong vdWs coupling in 1D vdWs materials leads to the thickness‐dependent physical properties, while weak vdWs coupling can preserve the single‐chain property even in their thick counterparts. Different from 2D vdWs materials, due to their nanoscale widths, identifying and producing ultrathin 1D molecular chains are challenging, severely limit their device applications. Thus, looking for novel 1D vdWs materials with weak interchain coupling is crucial. In this paper, the authors report that the 1D ternary vdWs material, Mo6Se2I8 with non‐centrosymmetric characteristic and strong optical anisotropy, exhibits weak interchain coupling. On one hand, the density functional theory (DFT) calculations theoretically demonstrate its thickness‐independent electronic structure, negligible interchain differential charge density, and weak cleavage energy as low as 0.256 J m−2. On the other hand, the thickness‐independent work function and low first‐order temperature coefficient of −0.0030 cm−1 K−1 further experimentally confirm its weak interchain coupling. Moreover, taking advantage of this weak vdWs coupling characteristic, the in situ exfoliation of the Mo6Se2I8 nanowires is achieved by using a nanoprobe in a scanning electron microscope (SEM), obtaining ultrathin molecular chains with a thickness of ≈1.2 nm.
A Biodegradable Supramolecular Adhesive with Robust Instant Wet Adhesion for Urgent Hemostasis and Wound Repair
Authors: Guo Hao , Zhang Wenjie , Jia Zhaoli , Wang Penghui , Shao Qing , Shen Haifeng , Li Jialing , Chen Qiang , Chi Bo 
Published: February 2024

AbstractSurgical adhesives are crucial for achieving rapid hemostasis and immediate wound management during clinical interventions. However, developing a tissue adhesive that combines instant adhesive strength with biodegradability in dynamic, wet, or hemorrhagic biological environments remains a persistent challenge. Here, a biodegradable supramolecular tissue adhesive with robust instant adhesion to wet tissue surfaces within 5 s is presented. The distinctive synergy of surface‐rich adhesive groups and the hydrophobic main chain enables the adhesive to surmount the hydration layer on the tissue surface, ensuring rapid adhesion. Importantly, the internal structure of this supramolecular adhesive significantly contributes to its exceptional holding adhesion strength. Additionally, in vivo experiments using a rat liver incision model and a skin injury model are conducted. These experiments demonstrate its effectiveness in emergency hemostasis and wound management. Consequently, this supramolecular tissue adhesive exhibits significant potential in surgical applications, addressing critical needs in urgent clinical scenarios and potentially making valuable contributions to the medical field.
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy
Authors: Metzloff Ann E. , Padilla Marshall S. , Gong Ningqiang , Billingsley Margaret M. , Han Xuexiang , Merolle Maria , Mai David , Figueroa‐Espada Christian G. , Thatte Ajay S. , Haley Rebecca M. , Mukalel Alvin J. , Hamilton Alex G. , Alameh Mohamad‐Gabriel , Weissman Drew , Sheppard Neil C. , June Carl H. , Mitchell Michael J. 
Published: February 2024

AbstractChimeric antigen receptor (CAR) T cell therapy has achieved remarkable clinical success in the treatment of hematological malignancies. However, producing these bespoke cancer‐killing cells is a complicated ex vivo process involving leukapheresis, artificial T cell activation, and CAR construct introduction. The activation step requires the engagement of CD3/TCR and CD28 and is vital for T cell transfection and differentiation. Though antigen‐presenting cells (APCs) facilitate activation in vivo, ex vivo activation relies on antibodies against CD3 and CD28 conjugated to magnetic beads. While effective, this artificial activation adds to the complexity of CAR T cell production as the beads must be removed prior to clinical implementation. To overcome this challenge, this work develops activating lipid nanoparticles (aLNPs) that mimic APCs to combine the activation of magnetic beads and the transfection capabilities of LNPs. It is shown that aLNPs enable one‐step activation and transfection of primary human T cells with the resulting mRNA CAR T cells reducing tumor burden in a murine xenograft model, validating aLNPs as a promising platform for the rapid production of mRNA CAR T cells.
DIW 3D Printing Aligned Catkins to Access Significant Enhanced Responsive Ionogel
Authors: Cao Pengrui , Yang Jing , Gong Junhui , Tao Liming , Wang Tingmei , Pei Xianqiang , Wang Qihua , Zhang Yaoming 
Published: February 2024

AbstractAlthough stimuli‐responsive gels have received significant attention due to their flexible structure and high tolerance to various stimuli, the high solvent content leads to relatively low mechanical properties and instability in performance due to water evaporation. This limits their application to some extent. Here, catkins enhanced ionogel is crafted that prevents solvent vaporization‐induced properties from abating yet remains humidity responsiveness. By using direct ink writing (DIW) 3D printing, the catkins can be aligned within the ionogel, resulting in a significant increase in ionic conductivity (0.17 S·cm−1) and mechanical properties (4.75 times). Moreover, the environment stability (−50–150 °C) and hygroscopicity of the ionic liquid (IL) allow the 3D‐printed composite to perform a controllable lubrication behavior in response to changes in humidity and temperature. This work demonstrates the significant enhancement of responsive ionogels through DIW 3D printing with aligned catkins and presents a new strategy for achieving the lubricating regulation.
Organophotocatalytic Carbamoylation of Morita‐Baylis‐Hillman Carbonates
Authors: Marchini Lucas , Vélez Jeimy A. C. , Andre Elias , Correia Jose Tiago M. , Moura Sidnei , Paixão Márcio W. 
Published: February 2024

AbstractHerein, we demonstrate that carbamoyl radicals generated through an organophotocatalytic protocol from 4‐carbamoyl‐dihydropyridines (carbamoyl‐DHPs) can be incorporated into Morita‐Baylis‐Hillman (MBH) carbonates, affording a range of polyfunctionalized scaffolds with yields ranging from 63–98%. Reaction monitoring experiments, scale‐up, reuse of the organophotocatalyst, and the hydrogenation of the succinamic ester's alkene moiety was also conducted, in order to showcase the mechanistic features and the robustness of this photochemical protocol.
Dual LiF/LiCl‐Rich Solid Electrolyte Interphases with Robust and Li+‐conductive Characteristics for 4.8 V Lithium Metal Batteries
Authors: Wang Huaping , Liu Jiandong , Jiang Gaoxue , Huang Junda , Wu Daxiong , Yang Gaojing , Ma Jianmin 
Published: February 2024

AbstractLithium metal batteries, which are constructed by lithium‐rich manganese‐based oxide (LRMO) cathode and Li metal anode, have attracted intensive attention due to its high energy density. However, the instability of both cathode and anode limits the practical application due to undesirable electrolyte decomposition at high voltage. To address these issues, an electrolyte engineering strategy is proposed for constructing robust, highly Li+‐conductive solid electrolyte interphases on both cathode and anode with chlorobenzene as the additive. Due to the high mechanical stability and interface dynamics of the LiCl‐endorsed, LiF‐rich cathode electrolyte interphase, both the electrolyte decomposition and transition metal ion dissolution are effectively inhibited. Meanwhile, robust LiF/LiCl‐rich solid electrolyte interphase can effectively repress the overgrowth of Li dendrites. The Li||LRMO battery with optimized 2.0 wt.% chlorobenzene demonstrates a high‐capacity retention of 86.1% after 200 cycles at 0.5 C.