bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using a thermal gradient table to study plant temperature signalling and response across a temperature spectrum
Authors: Praat Myrthe , Jiang Zhang , Earle Joe , Smeekens Sjef , Zanten Martijn 
Published: March 2024

Abstract

Plants must cope with ever-changing temperature conditions in their environment. In many plant species, suboptimal high and low temperatures can induce adaptive mechanisms that allow optimal performance. Thermomorphogenesis is the acclimation to high ambient temperature, whereas cold acclimation refers to the acquisition of cold tolerance following a period of low temperatures. The molecular mechanisms underlying thermomorphogenesis and cold acclimation are increasingly well understood but neither signalling components that have an apparent role in acclimation to both cold and warmth, nor factors determining dose-responsiveness, are currently well defined. This can be explained in part by practical limitations, as applying temperature gradients requires the use of multiple growth conditions simultaneously, usually unavailable in research laboratories. Here we demonstrate that commercially available thermal gradient tables can be used to grow and assess plants over a defined and adjustable steep temperature gradient within one experiment. We describe technical and thermodynamic aspects and provide considerations for plant growth and treatment. We show that plants display the expected morphological, physiological, developmental and molecular responses that are typically associated with high temperature and cold acclimation. This includes temperature dose-response effects on seed germination, hypocotyl elongation, leaf development, hyponasty, rosette growth, temperature marker gene expression, stomatal conductance, chlorophyll content, ion leakage and hydrogen peroxide levels. In conclusion, thermal gradient table systems enable standardized and predictable environments to study plant responses to varying temperature regimes and can be swiftly implemented in research on temperature signalling and response.
Discovering non-associated pressure-sensitive plasticity models with EUCLID
Authors: Xu Haotian , Flaschel Moritz , De Lorenzis Laura 
Published: March 2024

Abstract

We extend EUCLID (Efficient Unsupervised Constitutive Law Identification and Discovery) – a data-driven framework for automated material model discovery – to pressure-sensitive plasticity models, encompassing arbitrarily shaped yield surfaces with convexity constraints and non-associated flow rules. The method only requires full-field displacement and boundary force data from one single experiment and delivers constitutive laws as interpretable mathematical expressions. We construct a material model library for pressure-sensitive plasticity models with nonassociated flow rules in four steps: (1) a Fourier series describes an arbitrary yield surface shape in the deviatoric stress plane; (2) a pressure-sensitive term in the yield function defines the shape of the shear failure surface and determines plastic deformation under tension; (3) a compression cap term determines plastic deformation under compression; (4) a non-associated flow rule may be adopted to avoid the excessive dilatancy induced by plastic deformations. In contrast to traditional parameter identification methods, EUCLID is equipped with a sparsity promoting regularization to restrain the number of model parameters (and thus modeling features) to the minimum needed to accurately interpret the data, thus achieving a compromise between model simplicity and accuracy. The convexity of the learned yield surface is guaranteed by a set of constraints in the inverse optimization problem. We demonstrate the proposed approach in multiple numerical experiments with noisy data, and show the ability of EUCLID to accurately select a suitable material model from the starting library.
Combining Chaotic Transformations and MachineLearning Algorithms: Evaluating ExplainableArtificial Intelligence Model Performance
Authors: Özkurt Cem 
Published: March 2024

Abstract
The presented research encompasses the synthesis of data analysis, machine learning, and principles of explainable artificial intelligence. The study investigates chaotic transformations that affect the performance and interpretability of artificial intelligence models in complex systems. Three different chaotic systems, including Lorenz, Chen, and Rossler, are used to transform features in the dataset. Subsequently, these transformed datasets are analyzed using various machine learning algorithms such as Random Forest, Decision Tree, and CatBoost. Performance metrics are calculated to evaluate the effectiveness of each combination. Based on these findings, the Rossler chaotic system and CatBoost algorithm yielded the best results. The effects of the transformed data on class labels are elucidated using different explainable artificial intelligence models including ELI5, DALEX, and SHAP. In ELI5 and SHAP models, the feature most influencing class labels is identified as the y column. In the DALEX model, the largest impact is observed in the z column. Future studies aim to enhance the understanding and predictive capabilities of the model by integrating more chaotic systems and machine learning algorithms. Additionally, investigating the robustness of the proposed approach across various datasets and problem domains will ensure broader applicability and reliability.
“Masks” of fever of unknown origin in children
Authors: Fayzullina R. M. , Samigullina N. V. , Victorov V. V. 
Published: March 2024

The article presents an analysis of cases of hospitalized children with fever of unknown origin. Purpose: to study the nosological structure of the causes of fever of unknown genesis in hospitalized children. Material and methods: a retrospective analysis of the medical histories of children hospitalized in the pediatric department was carried out for 2022–2023. All children underwent a comprehensive laboratory and instrumental examination. Results: the largest proportion (43,9 %) were school-age children who, in addition to fever, had complaints of weakness (87,8 %) and decreased appetite (85,4 %). Anemia (51,2 %), acceleration of ESR (47,6 %) and an increase in C-reactive protein (45,1 %) were most often recorded in the analyses. The causes of fever of unknown origin in 65,9 % of children were infectious diseases, in 19,5 % — autonomic dysfunction syndrome with a violation of thermoregulation, in 6,1 % — systemic connective tissue diseases, in 4,9 % — oncological pathology, in 2,4 % — inflammatory diseases of the gastrointestinal tract. The results of the study can be applied in pediatric practice, monitoring of children with infectious pathology.
Response of climate change and land use land cover change on catchment-scale water balance components: a multi-site calibration approach
Authors: Kumar Shashi Bhushan , Mishra Ashok , Dash Sonam Sandeep 
Published: March 2024

ABSTRACT

The present study focused on evaluating the separate and combined response of land use land cover and climate change (CC) on future water balance components of a Subarnarekha River basin, spanning between the latitudes 21°33′N–23°18′N and longitudes 85°11′E–87°23′E, situated in the eastern India. The Soil and Water Assessment Tool is used for single-site calibration and multi-site calibration (MSC) of the model to characterize the future water balance components of the basin using the Cellular Automata-Markov model and climate projections under two representative concentration pathway (RCP) scenarios (4.5 and 8.5). The findings indicate that the model parameters obtained through MSC better represent spatial heterogeneity, making it the preferred calibration approach for model simulations. In the middle region of the basin, future annual water yield, groundwater recharge (GWR), and streamflow showed a reduction, respectively, by 46–47%, 29–30%, and 13–15%, while evapotranspiration showed an increase by 5–7% following projected CC under both RCP scenarios. The findings are relevant for policy-makers to mitigate the adverse effects of reduced GWR for sustainable water resources management. Future research may integrate reservoir operation frameworks to effectively address the water management issues of the basin.
Evaluation of UVLED disinfection for biofouling control during distribution of wastewater effluent
Authors: Randall Tara , Shlomo Inbar , Wells Emma , Real Breanna , Ma Ben , Linden Yarrow , Gamboa Jasmine , Friedler Eran , Linden Karl G. 
Published: March 2024

Abstract

A commercially available UVLED flow-through device, operating at 40 mJ/cm2, was examined for biofilm control on irrigation pipe material fed by wastewater effluent. Biofouling was monitored through total coliform counts, crystal violet (CV) staining, and ATP analyses. A UV fluence of 40 mJ/cm2 at 280 nm retarded biofilm formation; however, complete biofilm prevention by UV treatment was not achieved despite a high inactivation of planktonic cells. After 5 days of the study, the total coliform and CV biofilm quantification assays between the UV-treated and control bioreactor coupons were not statistically different. The total coliform counts indicated a stable biofilm cell concentration was reached; the CV assay showed biofilm biomass accumulation with time. The ATP results revealed higher coupon ATP on the UV-treated coupons than the control coupons by day 5. The results provoke an interesting discussion surrounding the contribution of viable cells, represented by total coliforms, and extracellular polymeric substance (EPS) to total biofilm biomass. This study also highlighted a need for further investigation into the relationship between ATP responses and complex UV-stress responses of diverse microbial communities as opposed to pure bacteria cultures.
Bibliometric analysis of global performance and trends of research on combined sewer overflows (CSOs) from 1990 to 2022
Authors: Yang Qingbang , Shen Chen , Li Zhonghong 
Published: March 2024

Abstract

Combined sewer overflows (CSOs) are one of the main sources of pollution in urban water systems and significantly impede the restoration of water body functionalities within urban rivers and lakes. To understand the research and frontier trends of CSOs comprehensively and systematically, a visual statistical analysis of the literature related to CSOs in the Web of Science core database from 1990 to 2022 was conducted using the bibliometric method using HistCite Pro and VOSviewer. The results reveal a total of 1,209 pertinent publications related to CSOs from 1990 to 2022, and the quantity of CSOs-related publications indicated an increasing trend. Investigations of the distribution and fate of typical pollutants in CSOs and their ecological effects on receiving waters and studies on pollution control technologies (source reduction, process control, and end-of-pipe treatment) are the current focus of CSOs research. CSOs pollution control technologies based on source reduction and the monitoring and control of emerging contaminants are at the forefront of scientific investigations on CSOs. This study systematically and comprehensively summarized current research topics and future research directions of CSOs, thus providing a reference for CSOs control and water environment management research.
Comunicação Inclusiva e Acessibilidade para o Turista Estrangeiro no Centro Histórico de João Pessoa
Authors: Franco Lis Vieira Araújo Silva , Madeira Amanda Sueli Pereira , Melo Alessandra Souza Queiroz , Oliveira Simone Neto de Santana , Vanzella Elídio 
Published: March 2024

A acessibilidade começou a ser estudada pelas lentes do turismo nas últimas décadas, com um crescente reconhecimento da importância de tornar os destinos turísticos disponíveis para todos. A moderna mobilidade internacional tem impulsionado o desenvolvimento de novas soluções para, não apenas promover uma maior integração desses turistas com meio, mas também assegurar uma compreensão histórico-cultural, que é fundamental para o local. Sendo assim, este estudo tem como objetivo analisar a comunicação do Centro Histórico de João Pessoa para atender à demanda turística internacional, a fim de verificar se a região possui recursos que promovam um turismo satisfatório para esse público. A pesquisa de abordagem qualitativa, com coleta de dados in loco, utilizou-se de técnica de observação estruturada em dez atrativos do Centro Histórico, além de entrevista não-estruturada com respectivos colaboradores. Com base na análise dos dados coletados, concluiu-se que a situação comunicacional no centro histórico de João Pessoa não atende às necessidades dos turistas internacionais. A falta de placas e sinais traduzidos, a falta de guias bilíngues e o pouco uso de recursos digitais podem comprometer experiência do turista, já que se tornar mais difícil de obter informações. Melhorias nessas áreas são necessárias para tornar o turismo em João Pessoa mais inclusivo e acessível para o público estrangeiro.
Remedial Dosing Recommendations for Sirolimus Delayed or Missed Dosages
Caused by Poor Medication Compliance in Pediatric Tuberous Sclerosis
Complex Patients
Authors: Yang Yang , Jiang Lei , Zhu Hai-Rong , Sun Wen-Xin , Mao Jing-Yu , Miao Jing-Wen , Wang Yi-Chen , He Su-Mei , Wang Dong-Dong , Chen Xiao 
Published: March 2024

Background::
Delayed or missed dosages caused by poor medication compliance significantly affected
the treatment of diseases in children.

Aims::
The present study aimed to investigate the influence of delayed or missed dosages on sirolimus pharmacokinetics
(PK) in pediatric tuberous sclerosis complex (TSC) patients and to recommend remedial dosages
for nonadherent patients.

Methods::
A published sirolimus population PK model in pediatric TSC patients was used to assess the influence
of different nonadherence scenarios and recommend optimally remedial dosages based on Monte Carlo simulation.
Thirteen nonadherent scenarios were simulated in this study, including delayed 2h, 4 h, 6 h, 8 h, 10
h, 12 h, 14 h, 16 h, 18 h, 20 h, 22 h, 23.5 h, and missed one dosage. Remedial dosing strategies contained
10-200% of scheduled dosages. The optimal remedial dosage was that with the maximum probability of returning
the individual therapeutic range.

Results::
For delayed or missed sirolimus dosages in pediatric TSC patients, when the delayed time was 0-8 h,
8-10 h, 10-18 h, 18-22.7 h, 22.7-24 h, 70%, 60%, 40%, 30%, 20% scheduled dosages were recommended to
take immediately. When one dosage was missed, 120% of scheduled dosages were recommended at the next
dose.

Conclusion::
It was the first time to recommend remedial dosages for delayed or missed sirolimus therapy
caused by poor medication compliance in pediatric TSC patients based on Monte Carlo simulation. Meanwhile,
the present study provided a potential solution for delayed or missed dosages in clinical practice.
A Phase I Clinical Study of the Pharmacokinetics and Safety of Prusogliptin
Tablets in Subjects with Mild to Moderate Hepatic Insufficiency and Normal
Liver Function
Authors: Zhang Huiting , Bian Yicong , Zhao Weifeng , Miao Liyan , Zhang Hua , Cui Juanjuan , Zhang Xiaofang , Zhang Xueyuan , Cai Wen 
Published: March 2024

Background:
Prusogliptin is a potent and selective DPP-4 inhibitor. In different animal models, Prusogliptin
showed potential efficacy in the treatment of type 2 diabetes. However, the knowledge of its pharmacokinetics
and safety in patients with liver dysfunction is limited.

Objectives:
The present study evaluated the pharmacokinetics and safety of Prusogliptin in subjects with mild
or moderate hepatic impairment compared with healthy subjects.

Methods:
According to the liver function of the subjects, we divided them into a mild liver dysfunction group,
a moderate liver dysfunction group and a normal liver function group. All subjects in three groups received a
single oral dose of Prusogliptin 100-mg tablets. Pharmacokinetics and safety index collection was carried out
before and after taking the drug. Plasma pharmacokinetics of Prusogliptin were evaluated, and geometric least-
-squares mean (GLSM) and associated 90% confidence intervals for insufficient groups versus the control
group were calculated for plasma exposures.

Results:
After a single oral administration of 100 mg of Prusogliptin tablets, the exposure level of Prusogliptin
in subjects with mild liver dysfunction was slightly higher than that in healthy subjects. The exposure level of
Prusogliptin was significantly increased in subjects with moderate liver dysfunction. There were no adverse
events in this study.

Conclusion:
The exposure level of Prusogliptin in subjects with liver dysfunction was higher than that in
healthy subjects. No participant was observed of adverse events. Prusogliptin tablets were safe and well tolerated
in Chinese subjects with mild to moderate liver dysfunction and normal liver function.
Use of Total Parenteral Nutrition (TPN) as a Vehicle for Drug Delivery
Authors: Bakrey Hossamaldeen , Shivgotra Riya , Abdu Abdulkadir , Soni Bindu , Shahtaghia Navid Reza , Jain Subheet Kumar , Thakur Shubham 
Published: March 2024

Abstract:
Total Parenteral Nutrition (TPN) is a method of providing nutrients directly into the
bloodstream for individuals who are unable to meet their nutritional needs through the normal digestive
process or gastrointestinal system. It provides macronutrients and micronutrients in a single
container, reducing handling and contamination risks and making it more cost-effective. TPN
has the potential to be used as a drug delivery system, with applications in combination therapies,
personalized medicine, and integrating advanced technologies. It can enhance drug dosage precision
and provide nutritional assistance, potentially reducing hospitalization and improving patient
outcomes. However, implementing new applications requires thorough testing and regulatory approval.
TPN could be particularly useful in pediatric and geriatric care and could also contribute
to global health by combating malnutrition in areas with limited medical resources. Healthcare professionals
prepare a sterile solution tailored to each patient's nutritional needs, and administration
involves a central venous catheter. However, the simultaneous administration of medications with
PN admixtures can result in pharmacological incompatibility, which can impact the stability of the
oil-in-water system. The European Society for Clinical Nutrition and Metabolism and the American
Society for Parenteral and Enteral Nutrition recommendations advise against including non-nutrient
drugs in PN admixtures due to safety concerns. This review focuses on the utilization of Total
Parenteral Nutrition (TPN) as a method for delivering drugs. It discusses the benefits and difficulties
associated with its commercial application and offers suggestions for future research endeavors.
Diagnostic Accuracy of Lung Ultrasonography Compared to Chest Radiography, BNP and Physical Examination in Patients with Dyspnea Suggestive of Pulmonary Edema: A Systematic Review and Meta-Analysis
Authors: Desai Dev H. , Bahattab Abeer A. , Barhoom Eman S. , Malafi Maria E. , Mujamammi Ahmed H. , Basalem Khulood S. , Sumaily Khalid M. , Sabi Essa M. , Mugibel Tayba A. , AlAfaleq Nouf O. , Bin Dahman Lotfi S. 
Published: March 2024

Background:
Pulmonary edema (PE) is the result of an abrupt increase in hydrostatic
pressure in the pulmonary capillaries that leads to leakage of fluid through microvascular endothelial
cells. This leads to a disruption of gas exchange in the lungs.

Aims:
This meta-analysis aimed to determine the diagnostic accuracy of lung ultrasonography
(LUS) in pulmonary edema.

Methods:
A systematic search was conducted using a strategy based on these search terms (Lung
ultrasonography, pulmonary edema, diagnostic accuracy); we searched PubMed, Google Scholar,
and the Cochrane Library. Out of 1029, 14 prospective cross-sectional and observational studies
with 2239 patients who reported the sensitivity and specificity of lung ultrasonography in diagnosing
pulmonary edema were selected. For inclusion and data extraction, an independent review of
citations was carried out. The data obtained were analyzed using SPSS, RevMan 5.3, and Stata
14.0 software. A quality assessment was conducted using the QUADAS-2 tool. The reference
gold standard was the final clinical diagnosis according to chest radiography, B-type natriuretic
peptide, and/or physical examination in dyspneic patients.

Results:
The overall sensitivity and specificity of lung ultrasonography in the diagnosis of pulmonary
edema were 0.86 (95% CI, 0.81-0.90) and 0.91 (95% CI, 0.90-0.93), respectively, with a
Younden index of 77.8%. The area under the receiver operating characteristic (ROC) curve was
0.889.

Conclusion:
The overall diagnostic odds ratio was 68.86. The results of this meta-analysis
suggest that lung ultrasonography is an effective non-invasive technique in the diagnosis of acute
pulmonary edema with rapid bedside examination and immediate interpretation.
Assessing the Importance of Content Versus Design for Successful Crowdfunding of Health Education Games: Online Survey Study
Authors: Huang Hong , Yu Han , Li Wanwan 
Published: March 2024

Abstract

Background
Health education games make health-related tasks enjoyable and interactive, thereby encouraging user participation. Entrepreneurs and health educators can leverage online crowdfunding platforms, such as Kickstarter, to transform their innovative ideas into funded projects.

Objective
This research focuses on health education game initiatives on Kickstarter. Through an online user survey, it aims to understand user perceptions and evaluate the significance of 8 distinct components that may influence the success of such crowdfunding initiatives.

Methods
A total of 75 participants evaluated games using 8 dimensions: game rules, learning objectives, narrative, content organization, motivation, interactivity, skill building, and assessment and feedback. The survey data were analyzed using descriptive statistical analysis, exploratory factor analysis, the Wilcoxon-Mann-Whitney test, and multivariate analysis.

Results
Exploratory data analysis showed that, among the 8 dimensions, skill building, content organization, and interactivity were the top-ranking dimensions most closely associated with crowdfunding health education game. The 8 dimensions can be grouped into 3 categories from the exploratory factor analysis: game content–, instruction-, and game design–related components. Further statistical analysis confirmed the correlation between these dimensions with the successful crowdfunding of health education games.

Conclusions
This empirical analysis identified critical factors for game proposal design that can increase the likelihood of securing crowdfunding support.