bluuebunny/crossref_metadata_2025_split huggingface dataset:
How to accelerate outdoor ageing of perovskite solar cells by indoor testing
Authors: Musiienko Artem , Hartono Noor Titan , Erdil Ulas , Nia Zahra , Khenkin Mark , Köbler Hans , Beckedahl Johannes , Ruske Florian , Schlatmann Rutger , Ulbrich Carolin , Abate Antonio 
Published: March 2024

Abstract

Halide perovskite is a material that shows great promise in producing renewable energy. It offers one of the most efficient forms of photovoltaics for large-scale production. However, while perovskite solar cell devices are more efficient than many established technologies, their long-term stability outdoors is still being determined.

Most studies have tested the stability of perovskite solar cells by keeping them under continuous illumination at maximum power point tracking for hundreds to a few thousand hours. Increasing the temperature has been proposed to accelerate degradation and project data collected relatively quickly to years of outdoor operations. However, PSCs undergo extensive degradation recovery during the resting time in dark and transient dynamics during the illumination they experience in day-night cycling. Therefore, an ageing protocol based on maximum power point tracking under continuous illumination cannot enable quantitative prediction of outdoor performances.

To address the challenge of predicting the outdoor stability of perovskite solar cells, we have demonstrated how ageing perovskite solar cells under light/dark cycling that reproduces outdoor functioning with controlled temperature and illumination conditions allows a predictive analysis. Our ageing protocol can accelerate the degradation of perovskite solar cells up to 46 times, i.e. 6 months of indoor testing can reproduce the standard 25 years of outdoor functioning. This result will speed up the studies of perovskite solar cells' stability and their commercialisation.
Advanced Spatiotemporal Chaos-Based Hash Functions for Enhanced Security
Authors: Li Yuxuan 
Published: March 2024

Abstract
The exploration of spatiotemporal chaos within nonlinear science has attracted significant attention recently. This research unveils an advanced framework for the cross-coupled map lattice, introducing a new spatiotemporal chaotic map. Our experimental assessments show that this refined cross-coupled map lattice outperforms its traditional version in chaotic dynamics. Given the increasing importance of hash functions in cryptography, data integrity verification, and data indexing, our study capitalizes on this innovative spatiotemporal chaos model. We devise a cutting-edge hash function utilizing the enhanced cross-coupled map lattice, capable of converting variable-length input data into fixed-size hash outputs of 128, 256, or 512 bits. Rigorous evaluation against diverse attack scenarios confirms the hash function's security and robustness. Our extensive experimental investigation underscores the hash function's solid security attributes, affirming its aptness for applications requiring stringent data integrity and cryptographic safeguards.
Receptor based study of ethanolic seed extract of Butea frondosa Roxb. Ex. Willd for involvement of cholinergic pathway in regulation with NO signaling to establish a potential anti-trematodal drug against Paramphistomum cervi
Authors: hazarika snigdha , Barua C. C. , Mohan P. , Khargharia S. , Hazorika M. , Tamuly S. , Baruah H. , Borah B. , Konwar P. , Choudhury D. 
Published: March 2024

Abstract
Purpose
Reports were found for traditional use of Butea frondosa Roxb. Ex. Willd for nematode infection but its anti-trematodal property and mechanistic action as an anthelmintic is not yet established. Therefore, present study was conducted to evaluate the same as an anti-trematodal agent.
Methods
Mature and healthy Paramphistomum cervi were collected from the rumen of freshly slaughtered cattle of local abattoir in warm HBSS. For in vitro motility study, six adult P. cervi in each Petri dish having different dilutions of extracts in HBSS ranging from 50, 150, 300, 500, 1000 and 3000 µg/ml and standard Oxyclozanide (10− 5 M) with control receiving only HBSS were taken and incubated at 38 ± 1° C for 5 h. Based on their gross visual motility, ethanolic seed extract of B. frondosa Roxb. Ex. Willd in various concentrations (100, 300, 1000 and 3000 µg/ml) were added to the isometrically mounted P. cervi on isolated tissue bath and their effects on spontaneous muscular activity of P. cervi were estimated.
Results
Ethanolic seed extract of B. frondosa Roxb. Ex. Willd @ 1000 and 3000 µg/ml showed complete death of worms within 1 hr of exposure which was comparable with the standard drug Oxyclozanide @10− 5 M. For neuropharmacological evaluation on isolated tissue bath, ethanolic seed extract of B. frondosa Roxb. Ex. Willd was found to be hyperpolarizing in nature and caused paralysis and death of worms @ 3000 µg/ml.
Predicting Dimensional Antidepressant Response to Repetitive Transcranial Magnetic Stimulation using Pretreatment Resting-state Functional Connectivity
Authors: Wade Benjamin , Barbour Tracy , Ellard Kristen , Camprodon Joan 
Published: March 2024

Abstract
Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression which modulates resting-state functional connectivity (RSFC) of depression-relevant neural circuits. To date, however, few studies have investigated whether individual treatment-related symptom changes are predictable from pretreatment RSFC. We use machine learning to predict dimensional changes in depressive symptoms using pretreatment RSFC. We hypothesized that changes in dimensional depressive symptoms would be predicted more accurately than scale total scores. Patients with depression (n = 26) underwent pretreatment RSFC MRI. Depressive symptoms were assessed with the 17-item Hamilton Depression Rating Scale (HDRS-17). Random forest regression (RFR) models were trained to predict treatment-related symptom changes captured by the HDRS-17, HDRS-6 and three previously identified HDRS subscales: core mood/anhedonia (CMA), somatic disturbances, and insomnia. Changes along the CMA, HDRS-17, and HDRS-6 were predicted significantly above chance, with 9%, 2%, and 2% of out-of-sample outcome variance explained, respectively (all p < 0.01). CMA changes were predicted more accurately than the HDRS-17 (p < 0.05). Higher baseline global connectivity (GC) of default mode network (DMN) subregions and the somatomotor network (SMN) predicted poorer outcomes, while higher GC of the right dorsal attention (DAN) frontoparietal control (FPCN), and visual networks (VN) predicted reduced CMA symptoms. HDRS-17 and HDRS-6 changes were predicted with similar GC patterns. These results suggest that RSFC spanning the DMN, SMN, DAN, FPCN, and VN subregions predict dimensional changes with significantly greater accuracy than syndromal changes following rTMS. These findings highlight the need to assess more granular clinical dimensions in therapeutic studies and echo earlier studies supporting that dimensional outcomes improve model accuracy.
Influence of Dental Status on Postoperative Complications in Major Visceral Surgical and Organ Transplantation Procedures - the BellyDent retrospective observational Study
Authors: Spitzner Anastasia , Mieth Markus , Langan Ewan A , Büchler Markus W , Michalski Christoph , Billmann Franck 
Published: March 2024

Abstract
Background The significance of dental status and oral hygiene on a range of medical conditions is well-recognised. However, the correlation between periodontitis, oral bacterial dysbiosis and visceral surgical outcomes is less well established. To this end, we study sought to determine the influence of dental health and oral hygiene on the rates of postoperative complications following major visceral and transplant surgery in an exploratory, single-center, retrospective, non-interventional study.Methods This investigation was conducted at the Department of General, Visceral, and Transplant Surgery, University Hospital Heidelberg, Germany. Patients were retrospectively enrolled in the study based on inclusion and exclusion criteria. The final patient cohort consisted of 417 patients. A bacteriology examination was added whenever possible for infectious complications.Results There was significant association between oral health and the rate of infectious complications for all surgical procecdures, excluding transplant surgery. However, this did not result in increased 30-day mortality rates, prolonged intensive care unit treatment or an increase in the length of hospital stay (LOS) for the cohort as a whole. In contrast there was a significant correlation between the presence of oral pathogens and postoperative complications for a group as a whole and the visceral surgery subgroup. Whilst this was not the case in the cohort who underwent transplant surgery, there was a correlation between oral health and LOS in this subgroup. Bacterial swabs supports the link between poor oraI health and infectious morbidity.Conclusions Dental status was a significant predictor of postoperative infectious complications in this visceral surgery cohort but not in patient who underwent organ transplantation. The association did not translate into increased mortality rates, extended ICU treatment or increased LOS. This study highlights the importance preoperative dental assessment and treatment prior to major surgery, particularly in the case of elective surgical procedures. Further research is required to determine the effect of oral health on surgical outcomes in order to inform future practice.Trial registration trial registered under the ethics-number S-082/2022 (Ethic Committee of the University Heidelberg).
Number of readmissions and determinants among patients with heart failure at referral hospitals in the Amhara region, Northwest Ethiopia; 2023.
Authors: Gedfew Mihretie , Tesfaye Bekele , Amha Haile , Wondie Tirusew , Gedif Getnet , Getaneh Wodajie , Akalu Tadesse Yirga , Yismaw Lieltework , Diress Gedefaw 
Published: March 2024

Abstract

Aim: This study aimed to determine the number of readmissions among patients with heart failure and identify the determinants of heart failure among patients at referral hospitals in the Amhara region, North western Ethiopia, in 2023.
Study design: A cross-sectional study design was employed using zero-inflated negative binomial models.
Methods: Data were collected from patients with heart failure at referral hospitals in the Amhara region from September 2022 to February 2023. The data were collected from 663 patients with heart failure using chart reviews and interviewer-administered questions.
Results: In this study, 237 (35.7%) patients with heart failure were readmitted at least once. The study showed that for every unit increase in the respiratory rate, the number of readmissions among patients with heart failure increased by 1.5% (IRR=.0.015; 95% CI=0.0004, 0.031), 0.044. In addition, as the duration of medication intake increased by one unit, the number of readmissions increased by 1.1% (IRR. =.0.011: 95% CI: 0.016, 0.051), 0.0001, while keeping all the other model variables constant. Similarly, compared with those of patients with good social support, the number of readmissions of patients with poor social support decreased by 59.4% (IRR=-1.595: 95% CI=-0.02, -0.005), 0.041. On the other hand, when thebody mass index increased by one unit, the odds of being in the always-zero group increased by 11.5% (IRR = 0.115: 95% CI: 0.035, 0.196), 0.004. Moreover, when the pulse rate increased by one unit, the odds of being in the always zero group decreased by 1.27% (IRR = -0.013: 95% CI: -0.025, -0.008), 0.036.
Implications for Clinical Practice: Determining the factors that lead to heart failure (HF) readmission is essential for developing effective interventions to lower the number of readmissions and hospital stays that may negatively impact patients’ and their families' overall socioeconomic status. Additionally, this study provides a baseline for the progress of nursing research and education as well as input for policy makers, all of which will help to improve nursing practice.
Patient or Public Contribution: Improves patients overall quality of care
Exploring the oncogenic potential of circSOD2 in clear cell renal cell carcinoma: a novel positive feedback loop
Authors: Yao Gaosheng , Fu Liangmin , Dai Junshang , Chen Jinwei , Liu Kezhi , Liang Hui , Wang Zhu , Deng Qiong , Wang Jieyan , Jin Meiyu , Chen Wei , Luo Junhang , Cao Jiazheng , Wei Jinhuan 
Published: March 2024

Abstract
Background Existing studies found that circular RNAs (circRNAs) act as sponges for micro RNAs (miRNAs) to control downstream genes. However, the specific functionalities and mechanisms of circRNAs in human clear cell renal cell carcinoma (ccRCC) have yet to be thoroughly investigated.Methods Patient cohorts from online database were used to screen candidate circRNAs, while another cohort from our hospital was obtained for validation. CircSOD2 was identified as a potential oncogenic target, and its relevant characteristics were investigated during ccRCC progression through various assays. A positive feedback loop containing downstream miRNA and target gene were identified using bioinformatics and was validated by luciferase reporter assays, RNA pull-down, and high-throughput sequencing.Results CircSOD2 expression was elevated in tumor samples and significantly correlated with overall survival (OS) and the tumor stage of ccRCC patients, which appeared in the enhanced proliferation, invasion, and migration of tumor cells. Through competitively bind to circSOD2, miR-532-3p can promote the expression of PAX5 and the progression of ccRCC, and such regulation can be salvaged by miR-532-3p inhibitor.Conclusion A novel positive feedback loop, PAX5/circSOD2/miR-532-3p/PAX5 was identified in the study, indicating that the loop may plan an important role in the diagnosis and prognostic prediction in ccRCC patients.
Correlation of Sex Hormone Binding Globulin with Metabolic Syndrome in US Adults: Insights from National Health and Nutrition Examination Survey (NHANES) 2013–2016
Authors: Yang Yang , Wang Jie , Liu Yuhang , Liu Shuwan , Liu Huabao , Tan Meiao 
Published: March 2024

Abstract

Background
Metabolic syndrome (MetS) poses a significant public health challenge worldwide, significantly impacting the health and quality of life of individuals. Increasing evidence suggests a strong correlation between MetS and sex hormone levels. The objective of this study is to explore the possible relationship between sex hormone binding globulin (SHBG) and Mets, aiming to furnish evidence that could inform the development of effective prevention strategies for Mets.
Methods
The data for this cross-sectional investigation were collected during the 2013–2016 cycle of the National Health and Nutrition Examination Survey (NHANES), from which 5,499 adults were sampled. The criteria established by the Adult Treatment Program III of the National Cholesterol Education Program were utilized to define MetS. SHBG were measured using a standardized technique. Multivariable-adjusted Logistic regression analysis, curve fitting, and threshold effects analysis were utilized to investigate the association between SHBG levels and Mets. Moreover, the stratified analyses and interaction tests of covariables were presented in the forest plot. Finally, sensitivity analysis was utilized to ensure the the robustness of the results.
Results
Among the participants, 1822 those had Mets. After adjusting for possible confounders, the SHBG level was associated with Mets (Odds ratio [OR], 0.984; 95% confidence interval [CI], 0.981–0.986; P < 0.01). The multivariable restricted cubic spline demonstrated a non-linear association between SHBG and Mets (P < 0.001). With two piecewise regression models, the adjusted OR of developing Mets was 0.964 (95% CI, 0.959–0.969; P < 0.001) among people with SHBG < 76.653nmol/L, but there was no correlation between SHBG and Mets in participants with SHBG ≥ 76.653nmol/L. The stability of the association between SHBG and MetS was confirmed through subgroup analysis and sensitivity analysis.
Conclusions
Our results suggest that reduced SHBG levels are associated with an increased prevalence of MetS in adults, particularly when SHBG levels are below 76.653 nmol/L. More investigation is required to comprehend the mechanisms underlying these results and to delve into their clinical implications.
A comparative study of remimazolam and midazolam in elderly patients during general anesthesia：a randomized controlled study
Authors: Yang Wan-jun , Geng Zhi-long , Gao Yuan-yuan , Cui Chao-yuan , Chen Zheng-ze , Tian Zi-wei , Guo Xi-lin , Zhang Ya-nan , Wang Lu , Huo Rui , Ma Chen-wei , Niu Jing 
Published: March 2024

Abstract
Background
Elderly patients are a vulnerable group with an elevated perioperative risk.Reduce the duration of anesthesia is important for older patients.Remimazolam is a benzodiazepine sedative that is indicated for the induction and maintenance during general anesthesia,with supposed advantages of rapid induction and rapid recovery.Most reports focused on non-elderly patients.
Aim
To compared the time of lost consciousness、PACU stay time and occurrence of adverse events in patients who are older than 65 years undergoing general anesthesia with remimazolam versus midazolam.
Methods
This study was conducted in a university hospital between February 2022 to March 2023. We included 100 patients aged 65 years or older under general anesthesia. Patients were administered intravenous remimazolam combined with midazolam. The primary outcome was the lose consciousness time. The secondary outcomes included the extubation time and the PACU stay time. We also recorded the total anesthesia time、extubation time、total dosage of drug administered、flumazenil use percentage and the occurrence of adverse events.
Results
A total of 96 patients undergoing general anesthesia were included in the final analysis, with 46 patients in remimazolam group, and 50 patients in midazolam group.The lose consciousness time was 304(222, 330)seconds in the remimazolam group and 95༈67, 25༉seconds in the midazolam group ,it was significantly lower in the midazolam group than in the remimazolam group (p = 0.000).The extubation time was 24.93 ± 11.617 minutes in the remimazolam group and 34.88 ± 19.740 minutes in the midazolam group ,it was significantly lower in the remimazolam group than in the midazolam group (p = 0.003).The PACU stay time was 55༈48, 64༉minutes in the remimazolam group and 65༈55, 85༉minutes in the midazolam group ,it was significantly lower in the remimazolam group than in the midazolam group (p = 0.001).The flumazenil use percentage was 6% in the remimazolam group and 20% in the midazolam group, it was significantly lower in the remimazolam group than in the midazolam group (p = 0.003).The possibly related to the intraoperative awareness percentage was 8.7% in the remimazolam group and 16% in the midazolam group, and there were no significant differences btween two groups (p = 0.280).
Conclusion
General anesthesia with remimazolam have proved the efficacy and safety in the surgery of elderly patients.The extubation time、PACU stay time and flumazenil use percentage was significantly lower in remimazolam than midazolam for elderly patients.
Indole moiety bearing Pyrimidine-2-thiolderivatives: Synthesis, Characterization and their insilico molecular docking studies in comparison to standard ligand drug
Authors: Neelaveni K. , RajendraPrasad Y. , Krishna K. , Lavanya J , k K. Srikanth 
Published: March 2024

Abstract
A novel indole moiety bearing pyrimidine-2-thiol derivatives was synthesized from chalcones using a designed synthesis procedure, a reaction of substituted acetophenones and indole-3-aldehyde. Further synthesized chalcones upon reaction with thiourea give novel pyrimidine derivatives bearing indole moiety. The developed indole-bearing pyrimidine2-thiol derivatives were characterized by physical and spectral analysis. Molecular docking studies were carried out at various targets using Auto Dock Vina software and revealed that some pyrimidine derivatives exhibit significant binding interaction with the active site regions of cyclooxygenase-1 (PDB ID: 3KK6), cyclooxygenase-2 (PDB ID: 5IKR) in comparison to standard ligand drug.
The prognostic impact of perioperative inflammatory status in elderly patients with gastric cancer
Authors: Toyokawa Takahiro , Yoshii Mami , Ishidate Takemi , Miyamoto Hironari , Kuroda Kenji , Miki Yuichiro , Tamura Tatsuro , Lee Shigeru , Yashiro Masakazu , Maeda Kiyoshi 
Published: March 2024

Abstract
Background
This study aimed to elucidate pre- and postoperative inflammatory prognostic factors, and to evaluate the impact of a combined perioperative inflammation marker for survival in elderly patients with gastric cancer.
Methods
We retrospectively examined 193 consecutive elderly patients ≥75 years of age who underwent curative gastrectomy for gastric cancer. Preoperative white blood cell (WBC) count (pre-WBC) and C-reactive protein (CRP) level (pre-CRP) and postoperative maximum WBC count (WBCmax) and maximum serum CRP level (CRPmax) were evaluated as prognostic inflammation markers.
Results
Among prognostic inflammation markers, multivariate analysis revealed pre-CRP and WBCmax as independent prognostic factors (Hazard ratio (HR) 1.645, 95% confidence interval (CI) 1.015–2.652, p = 0.043 and HR 1.913; 95%CI 1.142–3.221, p = 0.014, respectively). Perioperative inflammation score (PIS) constructed with pre-CRP and WBCmax allowed clear classification of patients into three groups for survival, and was revealed as an independent prognostic factor (PIS 1: HR 1.512, 95%CI 0.891–2.607 and PIS 2: HR 3.868, 95%CI 2.032–7.267, p < 0.001).
Conclusions
High pre-CRP and high WBCmax were independent prognostic factors for OS in elderly patients with gastric cancer after R0 resection. Furthermore, PIS is a promising prognostic indicator and may help surgeons offer optimized treatment strategies for elderly patients with gastric cancer.
Effects and mechanisms of jujube juice components on degradation of Alternaria mycotoxin by cold plasma
Authors: Wang Xiaoyuan , Liu Qing , Han Yike , Ge Zhenzhen , Wei Xiaopeng , Yan Yizhe , Zong Wei 
Published: March 2024

Abstract
The study examined the impact of jujube constituents on cold plasma (CP) degradation of alternariol (AOH) and alternariol monomethyl ether (AME), followed by assessing changes in CP electrochemical properties. The correlation between these properties and toxin degradation was analyzed to understand how jujube components influence the breakdown of AOH and AME. Results showed that when treated with CP for 3 minutes, 0.00350 mg/mL jujube protein degraded 49.0% of AOH and 48.8% of AME. Under the same treatment time, 0.0500 mg/mL jujube polysaccharide degraded AOH by 74.6% and AME by 95.8%. Conversely, Vc, K+, Ca2+, oleic acid, and linoleic acid exhibited negligible inhibitory effects on toxin degradation. Furthermore, following CP treatment, oxidation-reduction potential (△ORP), pH, conductivity, hydrogen peroxide (H2O2), hydroxyl radical (•OH), nitrate ion (NO3−), and nitrite ion (NO2−) contents in the jujube protein or polysaccharide system were significantly correlated with toxin degradation; thus confirming their association with reactive oxygen-nitrogen species (RONS). The presence of jujube protein or polysaccharide hindered the degradation of CP-mediated toxins by consuming reactive RONS resources. This study provides insights into how AOH and AME in jujube juice are degraded by CP, enabling more targeted and efficient elimination of foodborne toxins.