bluuebunny/crossref_metadata_2025_split huggingface dataset:
Yoga as an Add-on Therapy in Parkinson’s Disease: A Single Group Open-label Trial
Authors: Mailankody Pooja , Kamble Nitish , Bhattacharya Amitabh , Shubha Bhat G.S. , Arumugam Thamodharan , Thennarasu K. , Arasappa Rashmi , Varambally Shivarama , Yadav Ravi , Pal Pramod Kumar 
Published: March 2024

ABSTRACTObjective:We aimed to evaluate the effect of yoga on motor and non-motor symptoms and cortical excitability in patients with Parkinson’s disease (PD).Methods:We prospectively evaluated 17 patients with PD at baseline, after one month of conventional care, and after one month of supervised yoga sessions. The motor and non-motor symptoms were evaluated using the Unified Parkinson’s disease Rating Scale (motor part III), Hoehn and Yahr stage, Montreal Cognitive Assessment, Hamilton depression rating scale, Hamilton anxiety rating scale, non-motor symptoms questionnaire and World Health Organization quality of life questionnaire. Transcranial magnetic stimulation was used to record resting motor threshold, central motor conduction time, ipsilateral silent period (iSP), contralateral silent period (cSP), short interval intracortical inhibition (SICI), and intracortical facilitation.Results:The mean age of the patients was 55.5 ± 10.8 years, with a mean duration of illness of 4.0 ± 2.5 years. The postural stability of the patients significantly improved following yoga (0.59 ± 0.5 to 0.18 ± 0.4, p = 0.039). There was a significant reduction in the cSP from baseline (138.07 ± 27.5 ms) to 4 weeks of yoga therapy (116.94 ± 18.2 ms, p = 0.004). In addition, a significant reduction in SICI was observed after four weeks of yoga therapy (0.22 ± 0.10) to (0.46 ± 0.23), p = 0.004).Conclusion:Yoga intervention can significantly improve postural stability in patients with PD. A significant reduction of cSP and SICI suggests a reduction in GABAergic neurotransmission following yoga therapy that may underlie the improvement observed in postural stability.Clinicaltrialsgov identifier:CTRI/2019/02/017564
Strategies to promote language inclusion at 17 CTSA hubs
Authors: Sprague Martinez Linda , Araujo Brinkerhoff Cristina , Howard Riana C. , Feldman James A. , Kobetz Erin , White J. Tommy , Tumiel Berhalter Laurene , Bilheimer Alicia , Hoffman Megan , Isasi Carmen R. , Killough Cynthia , Martinez Julia , Chesley Johanna , Baig Arshiya A. , Foy Capri , Islam Nadia , Petruse Antonia , Rosales Carolina , Kipke Michele D. , Baezconde-Garbanati Lourdes , Battaglia Tracy A. , Lobb Rebecca 
Published: March 2024

Abstract
The prioritization of English language in clinical research is a barrier to translational science. We explored promising practices to advance the inclusion of people who speak languages other than English in research conducted within and supported by NIH Clinical Translational Science Award (CTSA) hubs. Key informant interviews were conducted with representatives (n = 24) from CTSA hubs (n = 17). Purposive sampling was used to identify CTSA hubs focused on language inclusion. Hubs electing to participate were interviewed via Zoom. Thematic analysis was performed to analyze interview transcripts. We report on strategies employed by hubs to advance linguistic inclusion and influence institutional change that were identified. Strategies ranged from translations, development of culturally relevant materials and consultations to policies and procedural changes and workforce initiatives. An existing framework was adapted to conceptualize hub strategies. Language justice is paramount to bringing more effective treatments to all people more quickly. Inclusion will require institutional transformation and CTSA hubs are well positioned to catalyze change.
Feasibility of regional center telehealth visits utilizing a rural research network in people with Parkinson’s disease
Authors: Virmani Tuhin , Pillai Lakshmi , Smith Veronica , Glover Aliyah , Abrams Derek , Farmer Phillip , Syed Shorabuddin , Spencer Horace J. , Kemp Aaron , Barron Kendall , Murray Tammaria , Morris Brenda , Bowers Bendi , Ward Angela , Imus Terri , Larson-Prior Linda J. , Lotia Mitesh , Prior Fred 
Published: March 2024

Abstract

Background:
Impaired motor and cognitive function can make travel cumbersome for People with Parkinson’s disease (PwPD). Over 50% of PwPD cared for at the University of Arkansas for Medical Sciences (UAMS) Movement Disorders Clinic reside over 30 miles from Little Rock. Improving access to clinical care for PwPD is needed.

Objective:
To explore the feasibility of remote clinic-to-clinic telehealth research visits for evaluation of multi-modal function in PwPD.

Methods:
PwPD residing within 30 miles of a UAMS Regional health center were enrolled and clinic-to-clinic telehealth visits were performed. Motor and non-motor disease assessments were administered and quantified. Results were compared to participants who performed at-home telehealth visits using the same protocols during the height of the COVID pandemic.

Results:
Compared to the at-home telehealth visit group (n = 50), the participants from regional centers (n = 13) had similar age and disease duration, but greater disease severity with higher total Unified Parkinson’s disease rating scale scores (Z = −2.218, p = 0.027) and lower Montreal Cognitive Assessment scores (Z = −3.350, p < 0.001). Regional center participants had lower incomes (Pearson’s chi = 21.3, p < 0.001), higher costs to attend visits (Pearson’s chi = 16.1, p = 0.003), and lived in more socioeconomically disadvantaged neighborhoods (Z = −3.120, p = 0.002). Prior research participation was lower in the regional center group (Pearson’s chi = 4.5, p = 0.034) but both groups indicated interest in future research participation.

Conclusions:
Regional center research visits in PwPD in medically underserved areas are feasible and could help improve access to care and research participation in these traditionally underrepresented populations.
On crosswords and jigsaw puzzles: the epistemic limits of the EU Courts and a board of appeal in handling empirical uncertainty
Authors: Krajewski Michał 
Published: March 2024

AbstractThis Article sheds new light on the long-running debate in EU legal studies about how intense the EU judicial review of complex and uncertain assessments requiring specialist knowledge could and should be. It argues that it is necessary to move beyond formulas and concepts hammered out in the judicial statements of reasons and consider how the institutional context affects legal epistemology. How likely is it that the judges form an independent opinion about the probative value of the presented evidence and the soundness of the administration’s specialist reasoning? How likely is it that their opinion is reliable? Answering these questions helps appraise the boundaries in which judicial review or proliferating administrative review by partly specialised boards of appeal foster the rule of law understood as the pursuit of non-arbitrariness. The Article examines recent case law of the EU Courts and the Board of Appeal of the European Chemical Agency concerning public health and environmental issues, in which complex and uncertain specialist assessments were prevalent. It contends that, due to institutional limitations of EU adjudicatory bodies, a further expansion of the rule of law in EU decision-making requiring specialist knowledge should be pursued through extra-judicial means fostering transparency, inclusiveness, and accountability.
The role of deubiquitinases in cardiac disease
Authors: Zhan Xiaona , Yang Yi , Li Qing , He Fan 
Published: March 2024

Abstract
Deubiquitinases are a group of proteins that identify and digest monoubiquitin chains or polyubiquitin chains attached to substrate proteins, preventing the substrate protein from being degraded by the ubiquitin-proteasome system. Deubiquitinases regulate cellular autophagy, metabolism and oxidative stress by acting on different substrate proteins. Recent studies have revealed that deubiquitinases act as a critical regulator in various cardiac diseases, and control the onset and progression of cardiac disease through a board range of mechanism. This review summarizes the function of different deubiquitinases in cardiac disease, including cardiac hypertrophy, myocardial infarction and diabetes mellitus-related cardiac disease. Besides, this review briefly recapitulates the role of deubiquitinases modulators in cardiac disease, providing the potential therapeutic targets in the future.
Slit-bearing gastropods in the Jane Longstaff Collection at the Natural History Museum, London from the Visean (Carboniferous) of Dalry, Ayrshire, Scotland
Authors: Karapunar Baran , Todd Jonathan A. , Nützel Alexander 
Published: March 2024

AbstractNatural history museums house numerous previously undescribed species and unknown information hidden in their collections. We describe lower Carboniferous slit-bearing gastropods (order Pleurotomariida, subclass Vetigastropoda; and family Goniasmatidae, subclass Caenogastropoda) from previously unreported gastropod collections made by Jane Longstaff (Jane Donald), one of the pioneering paleontologists of Paleozoic gastropods in the late nineteenth and early twentieth centuries. The gastropods were collected from the Lower Limestone Formation (Visean, Brigantian) near Dalry, Ayrshire, Scotland. The collection consists largely of microgastropods, many of which are unusually well-preserved including delicate ornament and protoconchs (larval shells). Three new pleurotomariidan species are described—Biarmeaspira heidelbergerae new species, Neilsonia seussae new species, Tapinotomaria longstaffae new species—in addition to seven species belonging to Borestus Thomas, 1940, Stegocoelia (Stegocoelia) Donald, 1889, Stegocoelia (Hypergonia) Donald, 1892, Donaldospira Batten, 1966, and Platyzona Knight, 1945. The caenogastropod-type protoconch is documented for the first time in Hypergonia, which is therefore placed in Goniasmatidae. The new data confirm that Neilsonia Thomas, 1940 (type genus of Neilsoniinae) belongs to Pleurotomariida and is distinct from the morphologically convergent Peruvispira Chronic, 1949 (Goniasmatidae). The selenizone morphology is identical in Biarmeaspira Mazaev, 2006 and Baylea de Koninck, 1883 during their early ontogeny, and Biarmeaspira develops an angulation on the selenizone (the diagnostic feature) in late ontogeny. This corroborates earlier suggestions that Biarmeaspira evolved from Baylea. Biarmeaspira heidelbergerae n. sp. is the first Carboniferous record of Biarmeaspira, which was previously only known from the Permian. The angulated selenizone evidently evolved several times in Pleurotomariida and the repeated appearance of this character in different groups (e.g., Phymatopleuridae, Eotomariidae, Pleurotomariidae) needs further studies using phylogenetic methods.UUID: http://zoobank.org/92ae9a99-5774-4ee9-bf5d-9a9319494ef6
On Their Own Terms: How Cocalera Organizing Expanded Indigenous Women’s Rights in Bolivia
Authors: Farthing Linda , Grisaffi Thomas 
Published: March 2024

AbstractA key element in the historically unprecedented advances in indigenous women’s political representation under Bolivia’s Evo Morales’s administration (2006–2019) was the influence that women coca growers played in the rural women’s indigenous organization known as the Bartolinas. Driven in no small measure by their resistance to the US-financed War on Drugs in the Chapare region, the cocaleras became both Bolivia’s strongest indigenous women’s organization and its most dedicated advocates for indigenous women’s rights. This article contends that intersectionality—of gender, class, and indigenous identities—is at the heart of understanding indigenous women’s transformation from “helpers” of a male-dominated peasant union to government ministers in the space of ten years. Not only did they effectively deploy chachawarmi, the Andean concept of gender complementarity, to advance their rights in a way consistent with their cultural identity and political loyalties, but they also benefited from the gains of a predominantly urban middle-class feminist movement even though they formally rejected the feminist movement’s composition and perceived orientation.
Fast as Potoroo: Radio continuum detection of a bow-shock pulsar wind nebula powered by pulsar J1638–4713
Authors: Lazarević Sanja , Filipović Miroslav D. , Dai Shi , Kothes Roland , Ahmad Adeel , Alsaberi Rami Z. E. , Balzan Joel C. F. , Barnes Luke A. , Cotton William D. , Edwards Philip G. , Gordon Yjan A. , Haberl Frank , Hopkins Andrew M. , Koribalski Bärbel S. , Leahy Denis , Maitra Chandreyee , Mićić Marko , Rowell Gavin , Sasaki Manami , Tothill Nicholas F. H. , Umana Grazia , Velović Velibor 
Published: March 2024

AbstractWe report the discovery of a bow-shock pulsar wind nebula (PWN), named Potoroo, and the detection of a young pulsar J1638$-$4713 that powers the nebula. We present a radio continuum study of the PWN based on 20-cm observations obtained from the Australian Square Kilometre Array Pathfinder (ASKAP) and MeerKAT. PSR J1638$-$4713 was identified using Parkes radio telescope observations at frequencies above 3 GHz. The pulsar has the second-highest dispersion measure of all known radio pulsars (1 553 pc cm$^{-3}$), a spin period of 65.74 ms and a spin-down luminosity of$\dot{E}=6.1\times10^{36}$erg s$^{-1}$. The PWN has a cometary morphology and one of the greatest projected lengths among all the observed pulsar radio tails, measuring over 21 pc for an assumed distance of 10 kpc. The remarkably long tail and atypically steep radio spectral index are attributed to the interplay of a supernova reverse shock and the PWN. The originating supernova remnant is not known so far. We estimated the pulsar kick velocity to be in the range of 1 000–2 000 km s$^{-1}$for ages between 23 and 10 kyr. The X-ray counterpart found inChandradata, CXOU J163802.6$-$471358, shows the same tail morphology as the radio source but is shorter by a factor of 10. The peak of the X-ray emission is offset from the peak of the radio total intensity (Stokes$\rm I$) emission by approximately 4.7$^{\prime\prime}$, but coincides well with circularly polarised (Stokes$\rm V$) emission. No infrared counterpart was found.
THE SUMMED PAPERFOLDING SEQUENCE
Authors: BUNDER MARTIN , BATES BRUCE , ARNOLD STEPHEN 
Published: March 2024

AbstractThe sequence
$a( 1) ,a( 2) ,a( 3) ,\ldots, $
labelled A088431 in the Online Encyclopedia of Integer Sequences, is defined by:
$a( n) $
is half of the
$( n+1) $
th component, that is, the
$( n+2) $
th term, of the continued fraction expansion of
$$ \begin{align*} \sum_{k=0}^{\infty }\frac{1}{2^{2^{k}}}. \end{align*} $$
Dimitri Hendriks has suggested that it is the sequence of run lengths of the paperfolding sequence, A014577. This paper proves several results for this summed paperfolding sequence and confirms Hendriks’s conjecture.
Imperfect relief: Challenges to the impartiality and identity of humanitarian action
Authors: DuBois Marc , Healy Sean 
Published: March 2024

AbstractOne of the four core humanitarian principles, impartiality's substantive ethical and deeply operational nature directs aid agencies to seek and deliver aid on the basis of non-discrimination and in proportion to the needs of crisis-affected people. Designed to operationalize the principle of humanity, impartiality is challenged by a plethora of external factors, such as the instrumentalization of aid, bureaucratic restriction, obstruction by States or non-State armed groups, and insecurity. Less visible and less examined are factors internal to aid agencies or the sector as a whole. Based on a desk review of the literature and the authors’ experience working with Médecins Sans Frontières, this article explores shortcomings in how the humanitarian sector understands and operationalizes impartiality, placing the focus on these internal factors.Beginning with the definition of impartiality, the article focuses on inadequacies in the practice of impartiality's twin pillars: non-discrimination and proportionality in the delivery of aid. Key conclusions include the necessity of an active rather than passive approach to non-discrimination, and the need for greater commitment to proportionality. In extending this analysis, the article looks more deeply at how aid organizations approach the humanitarian principles, identifying shortcomings in the way that the sector operationalizes, engages with and evaluates those principles. Given the sector's limited inclusion of or accountability towards people in crisis, its exercise of impartiality seems particularly problematic in relation to its power to decide the who and what of aid delivery, and to define the needs which it will consider humanitarian.The objective of this article is to reset humanitarians’ conceptual and operational understanding of impartiality in order to better reflect and protect humanity in humanitarian praxis, and to help humanitarians navigate the emergent challenges and critical discussions on humanitarian action's position in respect to climate change, triple-nexus programming, or simply a future where staggering levels of urgent needs vastly outstrip humanitarian resources.
Impact of Seesaw Spring Soil Moisture Anomalies in the Middle Latitudes on the General Circulation in Summer and Its Mechanism
Authors: Li Kechen , Wang Hao , Zhang Feimin , Wang Chenghai 
Published: March 2024

AbstractIn this paper, the effects of spring soil moisture (SM) anomalies in the mid‐latitudes on the atmospheric circulation in summer over the Northern Hemisphere (NH) are investigated. The results show that there are two regions of maximum interannual variability of the spring SM in the mid‐latitudes, which are located in central North America (CNA) and Europe and central Asia (ECA). In addition, the interannual variation of spring SM anomalies between CNA and ECA exhibits a seesaw pattern. The CNA–ECA seesaw pattern of the spring SM anomalies leads to the surface heat anomalies having opposite phases in CNA and ECA from spring to summer, which subsequently cause the opposite phase of baroclinicity anomalies in spring. The anomalous meridional temperature advections in spring cause the baroclinicity anomalies to have the same phase around CNA and ECA in summer. Corresponded with the same phase of baroclinicity anomalies, the anomalous centers of the stationary Rossby wave train (RWT) and Rossby wave source (RWS) have the same phase in CNA and ECA in summer. Through analysis of the vorticity budgets, the maintenance mechanism of the RWT in summer is considered as a positive feedback that anomalous meridional winds characterized by a RWT, transport the mean absolute vorticity and subsequently lead to an anomalous RWS, which in turn maintains the stationary RWT. Numerical experiments further demonstrate the effects of CNA–ECA seesaw pattern of spring SM anomalies on stationary RWT and RWS in summer.
Fine Structure of Magnetospheric Magnetosonic Waves: 1. Elementary Rising‐Tone Emissions Within Individual Harmonic
Authors: Li Jinxing , Bortnik Jacob , Tian Sheng , Ma Qianli , An Xin , Ma Donglai , Chu Xiangning , Wygant John , Kurth William S. , Hospodarsky George B. , Reeves Geoffrey D. , Funsten Herbert O. , Spence Harlan , Baker Daniel N. 
Published: March 2024

AbstractThe present study uncovers the fine structures of magnetosonic waves by investigating the EFW waveforms measured by Van Allen Probes. We show that each harmonic of the magnetosonic wave may consist of a series of elementary rising‐tone emissions, implying a nonlinear mechanism for the wave generation. By investigating an elementary rising‐tone magnetosonic wave that spans a wide frequency range, we show that the frequency sweep rate is likely proportional to the wave frequency. We studied compound rising‐tone magnetosonic waves, and found that they typically consist of multiple harmonics in the source region, and may gradually become continuous in frequency as they propagate away from source. Both elementary and compound rising‐tone magnetosonic waves last for ∼1 min which is close to the bounce period of the ring proton distribution, but their relation is not fully understood.
Assessing GPT-4 for cell type annotation in single-cell RNA-seq analysis
Authors: Hou Wenpin , Ji Zhicheng 
Published: March 2024

AbstractHere we demonstrate that the large language model GPT-4 can accurately annotate cell types using marker gene information in single-cell RNA sequencing analysis. When evaluated across hundreds of tissue and cell types, GPT-4 generates cell type annotations exhibiting strong concordance with manual annotations. This capability can considerably reduce the effort and expertise required for cell type annotation. Additionally, we have developed an R software package GPTCelltype for GPT-4’s automated cell type annotation.
A study on the relationship between recreational physical activity and audiovisual difficulty for older adults
Authors: Zhang Jipeng , Feng Rui , Cao Yiwen , Mo Hongfei 
Published: March 2024

AbstractAudiovisual difficulty are especially common in older adults. Audiovisual difficulty seriously affect the quality of life of older adults in their later years. It is a top priority to find out the related factors, and to intervene and prevent them. The purpose of this study was to explore the relationship between recreational physical activities and audiovisual difficulty in older adults. We hope that older adults can reduce the risk of hearing and visual difficulty through scientific physical activity. A total of 4,886 people were sampled from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2018. Recreational physical activity was assessed through the Global Physical Activity Questionnaire (GPAQ); Hearing and visual difficulty were assessed using the Disability Questionnaire (DLQ). Chi-square test was used for categorical variables and rank sum test was used for measurement variables. P < 0.05 was considered statistically significant (bilateral test). After univariate analysis, binary Logistic regression analysis was performed with recreational physical activity as the independent variable, statistically significant demographic variable as the covariate, and hearing and visual difficulty as the dependent variable, respectively. (1) After excluding all confounding variables, recreational physical activity was significantly associated with hearing difficulty (P < 0.001), odds ratio (OR) 0.657 (95% CI 0.5899–0.733); (2) Recreational physical activity was significantly associated with visual difficulty (P < 0.001), OR 0.731 (95% CI 0.630–0.849). (1) Recreational physical activity is the protective factor of hearing difficulty in older adults; (2) Recreational physical activity is a protective factor for visual difficulty in older adults.