bluuebunny/crossref_metadata_2025_split huggingface dataset:
Marketing plant‐based versus animal‐sourced foods in online grocery stores: A comparative content analysis of sustainability and other product claims in the United States
Authors: Gerber Suzannah , Dix Sadie R. , Cash Sean B. 
Published: March 2024

AbstractThe market share of e‐commerce grocery is swiftly rising, but online product listings may present different environmental sustainability and public health information. We analyzed product marketing content available on retailer websites and product images, comparing plant‐based (PBFs) and animal‐sourced foods (ASFs). Over sixteen thousand marketing and labeling content observations were gathered from seven leading U.S. e‐commerce grocery retailers for top‐selling ASFs and closely‐matched PBFs (N = 134; n = 68 PBFs, n = 66 ASFs), including sustainability, mandatory information, health, sourcing, and hedonic/emotional claims. PBFs averaged 47 total claims, ASFs 28. On‐web claims were substantially higher than on‐pack (PBFs 34 on‐web, 12 on‐pack; ASFs 19 and nine, respectively). On‐web information for the same products varied considerably across retailers, especially for sustainability and mandatory information. PBFs presented mostly sustainability claims on‐pack and health claims on‐web. ASFs led emotional claims and made almost no sustainability claims across settings. Across settings, mandatory information compliance was greater among PBFs whereas ASFs notably lacked disclosures for foods with major allergens. Online grocery lacks standardization—businesses should regard differences as opportunities for marketing sustainable foods.
Multifaceted impact of adipose conditioned media: Obesity‐driven promotion of prostate cancer and cancer stem cell dynamics
Authors: Erdogan Suat , Serttas Riza , Dibirdik Ilker , Turkekul Kader 
Published: March 2024

AbstractObesity is an established risk factor for the development and progression of prostate cancer (PC). This study used adipose conditioned media (ACM) from differentiated adipocytes to assess its effect on PC development and aggressiveness. Due to limited research on ACM's impact on isolated PC stem cells (PCSCs), we also examined CD44+ PCSCs. ACM notably boosted interleukin‐1β (IL‐1β), IL‐6, and IL‐8 production in normal prostate epithelial cells and LNCaP cells. It also increased IL‐6 and IL‐8 production in PC3 and CD44+ LNCaP cells, and IL‐1β and IL‐6 production in CD44+ PC3 cells. This indicates that ACM induces the production of inflammatory cytokines in both cancer and prostate epithelial cells. Furthermore, ACM promoted proliferation in androgen receptor (AR)‐negative PC3 cells, CD44+ PC3 PCSCs, and nonmalignant RWPE cells, without affecting AR‐positive LNCaP cells. In addition, ACM‐enhanced invasion and migration potential in both PC3 and CD44+ PC3 cells. Western blot analysis indicated the involvement of NF‐κB and AKT pathways in ACM‐induced proliferation in PC3 cells and NF‐κB in PCSCs. In ACM‐treated PC3 cells, E‐cadherin was downregulated, while N‐cadherin, Snail, vimentin, fibronectin, and Twist were upregulated, suggesting ACM‐induced invasion via classical epithelial‐to‐mesenchymal transition (EMT) pathways. In response to ACM, PCSCs exhibited increased expression of E‐cadherin, Snail, and vimentin, which are partial EMT markers promoting stemness and resistance to apoptosis. In addition, increased expressions of Nanog, Oct3/4, survivin, and Bcl‐2 were observed. Although the molecules we studied have diverse effects on cellular regulation, our data emphasize obesity's multifaceted role in promoting and aggressing PC, notably affecting PCSC populations.
Curcumin relieves oxaliplatin‐induced neuropathic pain via reducing inflammation and activating antioxidant response
Authors: Zhang Meng‐Wei , Sun Xu , Xu Yi‐Wen , Meng Wei , Tang Qiong , Gao Hui , Liu Ling , Chen Shao‐Hui 
Published: March 2024

AbstractOxaliplatin (OXA) has shown high effectiveness in the treatment of cancers, but its anticancer clinical effects often induce neurotoxicity leading to neuropathic pain. Oxidative damage and NLRP3 inflammasome play important roles in neuropathic pain development. Here, neuropathic pain mouse model was constructed by continuous intraperitoneal injection of OXA. OXA administration induced mechanical pain, spontaneous pain, thermal hyperalgesia and motor disability in mice. The spinal cord tissues of OXA mice exhibited the suppressed antioxidative response, the activated NLRP3 inflammasome mediated inflammatory responses, and the increased GSK‐3β activity. Next, we injected curcumin (CUR) intraperitoneally in OXA mice for seven consecutive days. CUR‐treated mice showed increased mechanical pain thresholds, reduced number of spontaneous flinches, increased paw withdrawal latency, and restored latency to fall. While in the spinal cord, CUR treatment inhibited the NLRP3 inflammasome mediated inflammatory response, increased Nrf2/GPX4‐mediated antioxidant responses, and decreased mitochondrial oxidative generation. Additionally, CUR combined with GSK‐3β through four covalent bonds and reduced GSK‐3β activity. In conclusion, our findings suggest that CUR treatment inhibits GSK‐3β activation, increases Nrf2 mediated antioxidant responses, inhibits oxidative damage and inflammatory reaction, and alleviates OXA‐induced neuropathic pain.
Efficacy of intravascular lithotripsy (IVL) in coronary stenosis with severe calcification: A multicenter systematic review and meta‐analysis
Authors: Sagris Marios , Ktenopoulos Nikolaos , Dimitriadis Kyriakos , Papanikolaou Angelos , Tzoumas Andreas , Terentes‐Printzios Dimitrios , Synetos Andreas , Soulaidopoulos Stergios , Lichtenberg Michael , Korosoglou Grigorios , Honton Benjamin , Tousoulis Dimitris , Tsioufis Costas , Toutouzas Konstantinos 
Published: March 2024

AbstractBackgroundWith heavily calcified coronary and peripheral artery lesions, lesion preparation is crucial before stent placement to avoid underexpansion, associated with stent thrombosis or restenosis and patency failure in the long‐term. Intravascular lithotripsy (IVL) technology disrupts superficial and deep calcium by using localized pulsative sonic pressure waves, making it to a promising tool for patients with severe calcification in coronary bed.AimsThe aim of the study is to systematically review and summarize available data regarding the safety and efficacy of IVL for lesion preparation in severely calcified coronary arteries before stenting.MethodsThis study was conducted according to the PRISMA guidelines. We systematically searched PubMed, SCOPUS, and Cochrane databases from their inception to February 23, 2023, for studies assessing the characteristics and outcomes of patients undergoing IVL before stent implantation. The diameter of the vessel lumen before and after IVL, as well as stent implantation, were analyzed. The occurrence of major adverse cardiovascular events (MACE) was assessed using a random‐effects model.ResultsThis meta‐analysis comprised 38 studies including 2977 patients with heavily calcified coronary lesions. The mean age was 72.2 ± 9.1 years, with an overall IVL clinical success of 93% (95% confidence interval [CI]: 91%−95%,I2 = 0%) and procedural success rate of 97% (95% CI: 95%−98%,I2 = 73.7%), while the in‐hospital and 30‐days incidence of MACE, myocardial infarction (MI), and death were 8% (95% CI: 6%−11%,I2 = 84.5%), 5% (95% CI: 2%−8%,I2 = 85.6%), and 2% (95% CI: 1%−3%,I2 = 69.3%), respectively. There was a significant increase in the vessel diameter (standardized mean difference [SMD]: 2.47, 95% CI: 1.77−3.17,I2 = 96%) and a decrease in diameter stenosis (SMD: −3.44, 95% CI: −4.36 to −2.52,I2 = 97.5%) immediately after IVL application, while it was observed further reduction in diameter stenosis (SMD: −6.57, 95% CI: −7.43 to −5.72,I2 = 95.8%) and increase in the vessel diameter (SMD: 4.37, 95% CI: 3.63−5.12,I2 = 96.7%) and the calculated lumen area (SMD: 3.23, 95% CI: 2.10−4.37,I2 = 98%), after stent implantation. The mean acute luminal gain following IVL and stent implantation was estimated to be 1.27 ± 0.6 and 1.94 ± 1.1 mm, respectively. Periprocedural complications were rare, with just a few cases of perforations, dissection, or no‐reflow phenomena recorded.ConclusionsIVL seems to be a safe and effective strategy for lesion preparation in severely calcified lesions before stent implantation in coronary arteries. Future prospective studies are now warranted to compare IVL to other lesion preparation strategies.
Elderly onset of MELAS carried an M.3243A >G mutation in a female with deafness and visual deficits: A case report
Authors: Zijun Lin , Xu Yi , Yujia Yang , Zhiqiang Xu 
Published: March 2024

Key Clinical MessageMELAS is a disorder with clinical variability that also responsible for a significant portion of unexplained hereditary or childhood‐onset hearing loss. Although patients typically present in childhood, the first stroke‐like episode can occur later in life in some patients, potentially related to a lower heteroplasmy level. It is crucial to consider MELAS as a potential cause of stroke‐like events if age at presentation and symptoms are atypical, especially among middle‐aged patients without vascular risk factors.AbstractMELAS syndrome (mitochondrial encephalopathy with lactic acidosis and stroke‐like episodes) is a rare genetic condition that most patients develop stroke‐like episodes before the age of 40. We report a 52‐year‐old female with a documented 40‐year history of progressive sensorineural hearing loss, developed a visual field deficit and stroke‐like events in her middle age who finally diagnosed was MELAS. The patient was started on vitamin E, l‐carnitine, l‐arginine, and coenzyme Q10 that gradually improved before dismissal from the hospital. This case highlights the importance of considering MELAS as a potential cause of stroke‐like events if imaging findings are atypical for cerebral infarction, especially among middle‐aged patients without vascular risk factors and an unusual cause of progressive sensorineural hearing loss.
Fiberoptic endoscopic assessment of dysphagia in a patient with cutaneous and oropharyngeal blisters
Authors: Bartholow Allison Hughes 
Published: March 2024

Key Clinical MessageDysphagia resulting from bulbous pemphigoid is a rare but significant manifestation. A 77‐year‐old with bullous pemphigoid with no neurological history presented with severe oropharyngeal dysphagia, attributable to underlying blistering and edema, as documented on a fiberoptic endoscopic swallow examination.
Building stabilized Cu0.17Mn0.03V2O5−□·2.16H2O cathode enables an outstanding room‐/low‐temperature aqueous Zn‐ion batteries
Authors: Wang Ao , Liu Dai‐Huo , Yang Lin , Xu Fang , Luo Dan , Dou Haozhen , Song Mengqin , Xu Chunyan , Zhang Beinuo , Zheng Jialin , Chen Zhongwei , Bai Zhengyu 
Published: March 2024

AbstractVanadium oxide cathode materials with stable crystal structure and fast Zn2+ storage capabilities are extremely important to achieving outstanding electrochemical performance in aqueous zinc‐ion batteries. In this work, a one‐step hydrothermal method was used to manipulate the bimetallic ion intercalation into the interlayer of vanadium oxide. The pre‐intercalated Cu ions act as pillars to pin the vanadium oxide (V‐O) layers, establishing stabilized two‐dimensional channels for fast Zn2+ diffusion. The occupation of Mn ions between V‐O interlayer further expands the layer spacing and increases the concentration of oxygen defects (Od), which boosts the Zn2+ diffusion kinetics. As a result, as‐prepared Cu0.17Mn0.03V2O5−□·2.16H2O cathode shows outstanding Zn‐storage capabilities under room‐ and low‐temperature environments (e.g., 440.3 mAh g−1 at room temperature and 294.3 mAh g−1 at −60°C). Importantly, it shows a long cycling life and high capacity retention of 93.4% over 2500 cycles at 2 A g−1 at −60°C. Furthermore, the reversible intercalation chemistry mechanisms during discharging/charging processes were revealed via operando X‐ray powder diffraction and ex situ Raman characterizations. The strategy of a couple of 3d transition metal doping provides a solution for the development of superior room‐/low‐temperature vanadium‐based cathode materials.
Multicationic Tetrahedra Networks: Alkaline‐Earth‐Centered Polyhedra and Non‐Condensed AlN6‐Octahedra in the Imidonitridophosphates AE2AlP8N15(NH) (AE=Ca, Sr, Ba)
Authors: Pointner Monika M. , Pritzl Reinhard M. , Albrecht Jonas M. , Blahusch Leopold , Wright Jonathan P. , Bright Eleanor Lawrence , Giacobbe Carlotta , Oeckler Oliver , Schnick Wolfgang 
Published: March 2024

AbstractA series of isostructural imidonitridophosphates AE2AlP8N15(NH) (AE=Ca, Sr, Ba) was synthesized at high‐pressure/high‐temperature conditions (1400 °C and 5–9 GPa) from alkaline‐earth metal nitrides or azides Ca3N2/Sr(N3)2/Ba(N3)2 and the binary nitrides AlN and P3N5. NH4F served as a hydrogen source and mineralizing agent. The crystal structures were determined by single‐crystal X‐ray diffraction and feature a three‐dimensional network of vertex‐sharing PN4‐tetrahedra forming diverse‐sized rings that are occupied by aluminum and alkaline earth ions. These structures represent another example of nitridophosphate‐based networks that simultaneously incorporate AlN6‐octahedra and alkaline‐earth‐centered polyhedra, with aluminum not participating in the tetrahedra network. They differ from previously reported ones by incorporating non‐condensed octahedra instead of strongly condensed octahedra units and contribute to the diversity of multicationic nitridophosphate network structures. The results are supported by atomic resolution EDX mapping, solid‐state NMR and FTIR measurements. Eu2+‐doped samples show strong luminescence with narrow emissions in the range of green to blue under UV excitation, marking another instance of Eu2+‐luminescence within imidonitridophosphates.
Photocatalytic Site‐Selective Cascade Radical Addition of Biaryl Ynones for the Construction of Spiro‐ and Fused Carbon Rings
Authors: Liu Kairui , Zhao Chunhang , Gu Liji , Li Xiang , Yan Jiali , Lao Siqi , Huan Weiwei , Zhang Yan 
Published: March 2024

Comprehensive SummaryFunctionalized free radical addition/cyclization reactions represent an efficient way for introducing new functionality or coupling fragments to molecules. Ynones are good regional selectivity radical acceptors in organic synthesis, and many of bio‐relevant cyclic compounds could be easily obtained by direct radical cyclization reaction. Here, we report a photocatalytic cascade radical addition of biaryl ynones, for the divergent synthesis of privileged carbon cycles. Additionally, further transformation of the multi‐functional group product into a variety of other derivatives demonstrates the synthetic value of this developed method.
Retino‐dural hemorrhages in infants are markers of degree of intracranial pathology, not of violent shaking
Authors: Brook Chris 
Published: March 2024

AbstractAimThis study analyzed whether retino‐dural hemorrhages in infants are markers of the degree of intracranial pathology, rather than evidence of violent shaking.MethodsUsing data from 420 infants with acute intracranial pathologies, comparison of clinical findings is made between cases diagnosed as abusive head trauma (AHT) and four categories: cases where caregivers report no trauma; cases of witnessed or admitted AHT; cases where caregivers report accidental trauma; and witnessed accidents. The data are then controlled for degree of intracranial pathology by only comparing cases in each category that have evidence of hypoxic‐ischemic swelling.ResultsAlthough categories differ in clinical findings when all data are considered, they do not differ when the data are controlled for degree of intracranial pathology.ConclusionsThe data suggest that the clinical findings widely considered to be indicative of shaking are instead markers of the degree of intracranial pathology. Previous results showing differences were driven by selection effects, whereby different categories have different fractions of serious cases. Most notably, caregiver and witnessed reports of accidental head trauma led doctors to explore intracranial pathologies across a broader spectrum of severity, including milder cases, as opposed to situations where no head trauma is reported.
Downregulation of salivary miR‐3928 as a potential biomarker in patients with oral squamous cell carcinoma and oral lichen planus
Authors: Farshbaf Alieh , Mohajertehran Farnaz , Aghaee‐Bakhtiari Seyed Hamid , Ayatollahi Hossein , Douzandeh Katayoun , Pakfetrat Atessa , Mohtasham Nooshin 
Published: March 2024

AbstractObjectivesRecent studies highlighted the role of miR expressed in saliva as reliable diagnostic and prognostic tools in the long‐term monitoring of cancer processes such as oral squamous carcinoma (OSCC). Based on a few previous studies, it seems the miR‐3928 can be considered a master regulator in carcinogenesis, and it can be therapeutically exploited. This is the first study that compared oral potentially malignant disorder (OLP) and malignant (OSCC) lesions for miR‐3928 expression.Materials and MethodsIn this cross‐sectional study, saliva samples from 30 healthy control individuals, 30 patients with erosive/atrophic oral lichen planus, and 31 patients with OSCC were collected. The evaluation of miR‐3928 expression by q‐PCR and its correlation with clinicopathological indices were analyzed by Shapiro−Wilk, Kruskal−Wallis, Pearson's χ2, and Mann−Whitney tests. The p‐value less than .05 indicated statistically significant results.ResultsBased on nonparametric Kruskal−Wallis test results, there was a statistically significant difference between the ages of three study groups (p < .05). This test demonstrated a statistically significant difference between the average of miR‐3928 expression in three study groups (p < .05). The result of the χ2 test showed a statistically significant difference in miR‐3928 expression between patients with OLP (p = .01) and also patients with OSCC (p < .0001) in comparison to the control group.ConclusionsThe salivary miR‐3928 can play a tumor suppressive role in the pathobiology of OSCC, and it is significantly downregulated in patients. According to the potential tumor suppressive role of miR‐3928 in the OSCC process, we can consider this microRNA as a biomarker for future early diagnosis, screening, and potential target therapy.
Effect of Gas Composition on Temperature and CO2 Conversion in a Gliding Arc Plasmatron reactor: Insights for Post‐Plasma Catalysis from Experiments and Computation
Authors: Xu Wencong , Van Alphen Senne , Galvita Vladimir V. , Meynen Vera , Bogaerts Annemie 
Published: March 2024

AbstractPlasma‐based CO2 conversion has attracted increasing interest. However, to understand the impact of plasma operation on post‐plasma processes, we studied the effect of adding N2, N2/CH4 and N2/CH4/H2O to a CO2 gliding arc plasmatron (GAP) to obtain valuable insights into their impact on exhaust stream composition and temperature, which will serve as feed gas and heat for post‐plasma catalysis (PPC). Adding N2 improves the CO2 conversion from 4 % to 13 %, and CH4 addition further promotes it to 44 %, and even to 61 % at lower gas flow rate (6 L/min), allowing a higher yield of CO and hydrogen for PPC. The addition of H2O, however, reduces the CO2 conversion from 55 % to 22 %, but it also lowers the energy cost, from 5.8 to 3 kJ/L. Regarding the temperature at 4.9 cm post‐plasma, N2 addition increases the temperature, while the CO2/CH4 ratio has no significant effect on temperature. We also calculated the temperature distribution with computational fluid dynamics simulations. The obtained temperature profiles (both experimental and calculated) show a decreasing trend with distance to the exhaust and provide insights in where to position a PPC bed.
Xanthones with multiple roles against diabetes: their synthesis, structure‐activity relationship, and mechanism studies
Authors: Ke Youhong , Xu Qinfang , Hu Jianling , Zhang Jianrun , Chen Shijian , Liu Zhijun , Peng Shuling , Zhang Chao , Chen Zhenqiang , Chen Heru 
Published: March 2024

AbstractA four‐step synthetic process has been developed to prepare 1,3,5,8‐tetrahydroxyxanthone (2a) and its isomer 1,3,7,8‐tetrahydroxyxanthone (2b). 25 more xanthones were also synthesized by a modified scheme. Xanthone 2a was identified as the most active inhibitor against both α‐glucosidase and aldose reductase (ALR2), with IC50 values of 7.8 ± 0.5 μM and 63.2 ± 0.6 nM, respectively, which was far active than acarbose (35.0 ± 0.1 μM), and a little more active than epalrestat (67.0 ± 3.0 nM). 2a was also confirmed as the most active antioxidant in vitro with EC50 value of 8.9 ± 0.1 μM. Any structural modification including methylation, deletion, and position change of hydroxyl group in 2a will cause an activity loss in inhibitory and antioxidation. By applying a H2O2‐induced oxidative stress nematode model, it was confirmed that xanthone 2a can be absorbed by Caenorhabditis elegans and is bioavailable to attenuate in vivo oxidative stress, including the effects on lifespan, superoxide dismutase, Catalase, and malondialdehyde. 2a was verified with in vivo hypoglycemic effect and mitigation of embryo malformations in high glucose. All our data support that xanthone 2a behaves triple roles and is a potential agent to treat diabetic mellitus, gestational diabetes mellitus, and diabetic complications.
Comprehensive analysis of vitamin D3 impurities in oily drug products using supercritical fluid chromatography–mass spectrometry
Authors: Jambo Hugues , Dispas Amandine , Pérez‐Mayán Leticia , Rodríguez Isaac , Ziemons Éric , Hubert Philippe 
Published: March 2024

AbstractVitamin D3, an essential micronutrient, often requires supplementation via medicines or food supplements, which necessitate quality control (QC). This study presents the development of a method for detecting and quantifying seven impurities of vitamin D3 in oily drug products using supercritical fluid chromatography–mass spectrometry (SFC‐MS). Targeted impurities include two esters of vitamin D3 and five non‐esters including four that are isobaric to vitamin D3. Firstly, a screening study highlighted the Torus 1‐AA column and acetonitrile modifier as adequate for the separation, followed by optimization of the SFC conditions. Secondly, make‐up solvent composition and MS settings were optimized to reach high sensitivity. For both the separation and MS response, the screening design of experiments proved useful. Lastly, a fast saponification and liquid–liquid extraction method was developed, enabling efficient sample cleanup and impurities recovery from the complex oily matrix. The SFC‐MS method suitability was assessed in two validation studies. The first study employed the ICH Q2 guideline for impurity limit test to demonstrate method specificity and establish a limit of detection (LOD) and a limit of quantification (LOQ) at 0.2% and 0.5%, respectively, for ester impurities. The second study conducted a comprehensive quantitative assessment for three non‐ester impurities using a total error approach, determining method validity through accuracy profiles. The validated method exhibited reliable performance across impurity concentrations from 0.1% to 2.0%, with estimated LODs ranging from 2 to 7 ng/mL. This study further promotes SFC‐MS as a valuable, versatile, and green tool for routine pharmaceutical QC.