bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calcimimetics treatment strategy for serum calcium and phosphate management in patients with secondary hyperparathyroidism undergoing dialysis: A systematic review and meta‐analysis of randomized studies
Authors: Nakai Kentaro , Kono Keiji , Yamada Shunsuke , Taniguchi Masatomo , Hamano Takayuki , Fukagawa Masafumi 
Published: March 2024

AbstractIntroductionSeveral calcimimetics, other than cinacalcet, are commercially available; however, their effects on calcium and phosphate levels have not yet been fully studied. We conducted a systematic review and meta‐analysis of randomized controlled trials to evaluate the impact of calcimimetics on the management of serum calcium and phosphate levels in patients with secondary hyperparathyroidism undergoing dialysis.MethodsA systematic literature search through October 2023 and a meta‐analysis were conducted on the effects of upacicalcet, etelcalcetide, evocalcet, and cinacalcet on serum calcium and phosphate levels in patients with secondary hyperparathyroidism undergoing dialysis; we searched PubMed, Ovid MEDLINE, and the Cochrane Central Register of Controlled Trials, and 21 studies comprising 6371 patients undergoing dialysis were included.ResultsParticipants treated with calcimimetics had lower serum calcium and phosphate levels than placebo.ConclusionCalcimimetics significantly reduced serum calcium and phosphate levels compared to placebo in patients with secondary hyperparathyroidism undergoing dialysis, independent of therapeutic strategy or concomitant vitamin D treatment.
Timing and causes of death to 1 year among children presenting to emergency departments
Authors: Ames Stefanie G. , Salvi Apoorva , Lin Amber , Malveau Susan , Mann N. Clay , Jenkins Peter C. , Hansen Matthew , Papa Linda , Schmitz Sabrina , Sabogal Cesar , Newgard Craig D. ,   for the Pediatric Readiness Study Group
Published: March 2024

AbstractBackground and objectivesA better characterization of deaths in children following emergency care is needed to inform timely interventions. This study aimed to describe the timing, location, and causes of death to 1 year among a cohort of injured and medically ill children.MethodsWe conducted a retrospective cohort study of children <18 years requiring emergency care in six states from January 1, 2012, through December 31, 2017, with follow‐up through December 31, 2018, for patients who were not discharged from the emergency department (ED). In this cohort, 1‐year mortality, time to death within 1 year, and causes of death were assessed from ED, inpatient, and vital status records.ResultsThere were 546,044 children during the 6‐year period. The 1‐year mortality rate was 2.2% (n = 1356) for injured children and 1.4% (n = 6687) for medically ill children. Matched death certificates were available for 861 (63.5%) of 1356 deaths in the injury cohort and for 4712 (70.5%) of 6687 deaths in the medical cohort. Among deaths in the injury cohort, 1274 (94.0%) occurred in the ED or hospital. The most common causes of death were motor vehicle collisions, firearm injuries, and pedestrian injuries. Among the 6687 deaths in the medical cohort, 5081 (76.0%) children died in the ED or hospital (primarily in the ED) and 1606 (24.0%) occurred after hospital discharge. The most common causes of death were sudden infant death syndrome, suffocation and drowning, and congenital conditions.ConclusionsThe 1‐year mortality of children presenting to an ED is 2.2% for injured children and 1.4% for medically ill children with most deaths occurring in the ED. Future interventional trials, quality improvement efforts, and health policy focused in the ED could have the potential to improve outcomes of pediatric patients.
Identification of polymorphic markers for germplasm conservation of three precious Chinese palace goldfish using whole‐genome sequencing
Authors: Huang Yuwei , Cao Aiying , Zhang Beiyuan , Li Sen , He Chuan , Gao Jian , Cao Xiaojuan 
Published: March 2024

AbstractChina was the first country in the world to breed goldfish and has generated many unique goldfish varieties, including the most aristocratic Chinese palace goldfish. Due to the lack of scientific research on Chinese palace goldfish, their selection and breeding are mainly carried out through traditional hybridization, leading to serious inbreeding and the degradation of germplasm resources. To this end, whole‐genome resequencing was performed to understand the genetic variation among three different varieties (eggpompons, goosehead, and tigerhead) from nine core conserved populations in China. A total of 15 polymorphic SSRs were developed for population genetics, and all tested populations were considered moderately polymorphic with an average polymorphism information content value of 0.4943. Genetic diversity in different varieties showed that all conserved populations were well protected with the potential for continued exploitation. This study provides reliable molecular tools and a basis for designing conservation and management programs in Chinese palace goldfish.
Skeletal muscle mass increases after viral eradication with direct‐acting antivirals in patients with chronic hepatitis C: A longitudinal study
Authors: Coelho Marta Paula Pereira , de Vries Thais Pontello , Pires Aline Marcos , Parreira Milena Pereira , de Alvarenga Érika Ramos , Cambraia Rodrigo Dias , dos Santos Rodrigo Ribeiro , Bezerra Juliana Maria Trindade , Colosimo Enrico Antonio , Rocha Gifone Aguiar , Silva Luciana Diniz 
Published: March 2024

SummaryBackgroundResults of studies evaluating the effect of viral eradication following direct‐acting antiviral (DDA) therapy on skeletal muscle mass of patients with chronic hepatitis C (CHC) are scarce.AimTo assess the components of sarcopenia (low muscle mass, low muscle strength and low physical performance) in a cohort of CHC individuals before and after DAA therapy.MethodsWe performed a longitudinal study of patients with CHC who underwent body composition assessment before (T0), and at 12 (T1) and 48 (T2) weeks after DDA therapy. Bioelectrical Impedance Analysis was used to assess skeletal mass muscle (SM) and phase angle (PhA). SM index (SMI) was calculated by dividing the SM by squared height. Muscle function was evaluated by hand grip strength (HGS) and timed up‐and‐go (TUG) test. Mixed‐effects linear regression models were fitted to SMI, HGS and physical performance and were used to test the effect of HCV eradication by DAA.Results62 outpatients (mean age, 58.6 ± 10.8 years; 58% with compensated cirrhosis) were included. Significant decreases in liver fibrosis markers and an increase of 0.20 and 0.22 kg/m2 in the SMI were observed at T1 and T2. Following DAA therapy, an increase of one unit of PhA was associated with a reduction of 0.38 min in TUG.ConclusionHCV eradication with DAA therapy was associated with a dynamic reduction of non‐invasive markers of liver fibrosis and increased muscle mass in 62 patients with CHC who had an undetectable HCV load at 12 weeks after completion of antiviral treatment.
Small‐molecule inhibitor HI‐TOPK‐032 improves NK‐92MI cell infiltration into ovarian tumours
Authors: Deng Mengqi , Yang Ruiye , Sun Qi , Zhang Jiamin , Miao Jinwei 
Published: March 2024

AbstractThe effectiveness of natural killer (NK) cells transferred adoptively in combating solid tumours is limited by challenges such as their difficulty in penetrating tumours from the bloodstream and maintaining viability without the support of interleukin‐2 (IL‐2). Genetically modified NK‐92MI cells, which can release IL‐2 to sustain their viability, have been identified as a promising alternative. This adaptation addresses the negative consequences of systemic IL‐2 administration. The role of PSD‐95/discs large/ZO‐1 (PDZ)‐binding kinase (PBK) in cancer development is recognized, but its effects on immunity are not fully understood. This study explores how PBK expression influences the ability of NK‐92MI cells to infiltrate ovarian tumours. Elevated levels of PBK expression have been found in various cancers, including ovarian cancer (OV), with analyses showing higher PBK mRNA levels in tumour tissues compared to normal ones. Immunohistochemistry has confirmed increased PBK expression in OV tissues. Investigations into PBK's role in immune regulation reveal its association with immune cell infiltration, indicating a potentially compromised immune environment in OV with high PBK expression. The small‐molecule inhibitor HI‐TOPK‐032, which inhibits PBK, enhances the cytotoxicity of NK‐92MI cells toward OV cells. It increases the production of interferon‐γ and tumour necrosis factor‐α, reduces apoptosis and encourages cell proliferation. Mechanistic studies showed that contact with OV cells treated with HI‐TOPK‐032 upregulates CD107a on NK‐92 cells. In vivo studies demonstrated that HI‐TOPK‐032 improves the antitumour effects of NK‐92MI cells in OVCAR3Luc xenografts, extending survival without significant side effects. Safety assessments in mice confirm HI‐TOPK‐032's favourable safety profile, highlighting its potential as a viable antitumour therapy. These results suggest that combining NK‐92MI cells with HI‐TOPK‐032 enhances antitumour effectiveness against OV, indicating a promising, safe and effective treatment strategy that warrants further clinical investigation.
Exploring the relationship between personality traits and locus of control in early adolescence. Does gender play a role?
Authors: Filipiak Sara , Łubianka Beata 
Published: March 2024

AbstractThe main aim of this study was to analyse associations between the five‐factor model personality traits and locus of control of successes and failures based on the theory of social learning and to assess whether gender moderated relationships between these variables in Polish early adolescents. The following instruments were used: the Picture Based Personality Survey for Children and the Locus of Control Questionnaire. A total of 1016 students participated in the study, including 49% boys and 51% girls. Both for girls and boys, the highest correlations were found between conscientiousness and locus of control in success situations. Neuroticism correlated negatively with the two types of locus of control. A moderating effect of gender was observed between openness to experience and locus of control of successes, and it was stronger in girls than in boys.
Bark and ambrosia beetles on native and transplanted dead wood along an altitudinal tropical forest gradient
Authors: Weiss Matthias , Zimová Kateřina , Mogia Martin , Novotny Vojtech 
Published: March 2024

AbstractGlobal warming is expected to shift the distribution ranges of many species towards higher latitudes and altitudes. This will rewire plant‐herbivore food webs as new combinations of herbivore species encounter novel host plants. We investigated the effects of a simulated altitudinal shift in an herbivore‐host community of bark and ambrosia beetles on fig trees in a tropical mountain forest on Mt. Wilhelm, Papua New Guinea. We reared beetles from wood baits cut from five local Ficus species in their natural altitudinal ranges, between 200 and 1700 m a. s. l. Further, we transplanted baits from three of these tree species 500 m below the limits of their natural distribution range, to simulate a mean temperature increase of 2.7°C. Beetle species richness declined, and their species composition changed with increasing elevation. Furthermore, while altitude explained a large proportion of variance in beetle composition, host tree species was more important for bark beetles than ambrosia beetles. Beetle communities that assembled on the transplanted baits were similar in diversity and host specificity to those on the fig trees native to the same elevation, but also contained a number of unique species. Overall, these results indicate that saproxylic beetles in this tropical forest are highly resilient and flexible to the potential effects of climate change.Abstract in Česky is available with online material.
Multivariate analysis of the effect of keratinized mucosa on peri‐implant tissues with platform switching: A retrospective study
Authors: Suzuki Azusa , Nakano Tamaki , Inoue Masaki , Isigaki Shoichi 
Published: March 2024

AbstractBackgroundIn recent years, platform switching implant treatment has been increasing, which is believed to minimize bone loss around the implant after placement. However, there have been no reports on the relationship between keratinized mucosa width (KMW) and bone loss and soft tissue recession in platform switching implants.ObjectiveWe evaluated the effect of the KMW on the amount of bone loss and soft tissue recession around a platform switching implant retrospectively using multivariate analysis.Materials and MethodsThis one‐year retrospective study included 91 implants in 48 patients. Age, sex, a history of periodontitis, implant location, oral hygiene status, and the KMW were included as explanatory variables to evaluate bone loss (BL) and buccal gingival height (GH). Generalized estimating equations (GEEs) were used to evaluate the effect of the KMW on platform switching peri‐implant tissues.ResultsThe mean bone loss on the mesial (ΔBLm), distal (ΔBLd), and buccal (ΔBLb) sides of the implant were 0.16 ± 0.27 mm, 0.19 ± 0.34 mm, and 0.24 ± 0.50 mm, respectively, at 1 year after superstructure placement. The mean amount of change of GH (ΔGH) on the buccal side was 0.30 ± 0.47 mm. After correcting for confounders using GEEs, the results suggested that KMW <1.5 mm was a significant factor (P < 0.001) for bone loss over time in ΔBLm, ΔBLd, and ΔBLb. In addition, for soft tissues on the buccal side, KMW <1.5 mm was a significant factor for ΔGH reduction over time (P < 0.001).ConclusionsKeratinized mucosa width ≥1.5 mm was associated with a higher probability less hard and soft tissue recession around the platform switching implant after 1 year from superstructure placement.
Interaction between regional temperature and shade level shapes saproxylic beetle communities
Authors: Goßmann Anika , Öckinger Erik , Schroeder Martin , Lindman Ly , Ranius Thomas 
Published: March 2024

AbstractAimThe ‘concept of relative constancy of habitats’ assumes that species differ in their habitat preferences depending on the regional temperature so that all populations experience similar microclimatic conditions. Our aim was to assess the relevance of this concept by disentangling the effects of shade level and regional temperature on southern and northern distributed saproxylic (=dead wood dependent) beetle species.LocationSweden.MethodsWe established a field experiment by placing 435 logs of Norway spruce (Picea abies) along shade gradients in six regions differing in regional temperature (along a 1200 km latitudinal gradient). For each log, we sampled the saproxylic beetle community and calculated the Community Temperature Index (CTI), indicating to what extent the community is dominated by southern or northern species.ResultsSpecies richness and total abundance were better explained by shade level, whereas species composition was better explained by study region. In colder regions, CTI varied along the shade gradient, whereas in warmer regions, CTI was more similar along the shade gradient. Moreover, in colder regions, the number of southern species was higher in sun‐exposed logs, whereas in warmer regions, the number of southern species was higher in shaded logs. This supports the concept of relative constancy of habitats. In contrast, northern species preferred shaded conditions regardless of the regional temperature.Main ConclusionsRegional temperature, shade level and resulting microclimate are important drivers of species richness, total abundance and composition. Occurrence patterns of saproxylic beetle species follow to some extent the concept of relative constancy of habitats since their habitat preferences vary with regional temperature. Northern species are of conservation concern due to disadvantages by climate warming and clear‐cutting. They are favoured by preserving forests with rarely disturbed canopies.
Comparative transcriptomic characterization of the ovary in the spawning process of the mud crab Scylla paramamosain
Authors: Tu Shisheng , Yu Guohong , Ge Fuqiang , Xu Rui , Jin Zhongwen , Xie Xi , Zhu Dongfa 
Published: March 2024

AbstractOviposition is induced upon mating in most insects. Spawning is a physiological process that is fundamental for the reproduction of Scylla paramamosain. However, the molecular mechanisms underlying the spawning process in this species are poorly understood. Herein, comprehensive ovary transcriptomic analysis was conducted at the germinal vesicle breakdown stage (GVBD), spawning stage, 0.5 h post‐spawning stage, and 24 h post‐spawning stage of S. paramamosain for gene discovery. A total of 67,230 unigenes were generated, and 27,975 (41.61%) unigenes were annotated. Meanwhile, the differentially expressed genes (DEGs) between the different groups were identified, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis was subsequently conducted. These results suggested that octopamine (OA) and tyramine (TA) could induce oviposition, while dopamine (DA) and serotonin (5‐hydroxytryptamine [5‐HT]) inhibit oviposition. The 20‐hydroxyecdysone (20E) and methyl farnesoate (MF) signal pathways might be positively associated with oviposition. Furthermore, numerous transcripts that encode neuropeptides and their G‐protein‐coupled receptors (GPCRs), such as CNMamide, RYamide, ecdysis‐triggering hormone (ETH), GPA2/GPB5 receptor, and Moody receptor, appear to be differentially expressed during the spawning process. Eleven unigenes were selected for qRT‐PCR and the pattern was found to be consistent with the transcriptome expression pattern. Our work is the first spawning‐related investigation of S. paramamosain focusing on the ovary at the whole transcriptome level. These findings assist in improving our understanding of spawning regulation in S. paramamosain and provide information for oviposition studies in other crustaceans.
The association between body mass index and health‐related quality of life in the 2017 and 2018 health survey of England data: A cross‐sectional observational analysis
Authors: Luah Xiao Wen , Holst‐Hansen Thomas , Lübker Christopher 
Published: March 2024

AbstractAimTo provide an updated estimate of the association between body mass index (BMI) and health‐related quality of life (HRQoL) among the general population in England and to identify population subgroups with the highest potential utility gains from obesity interventions.Materials and MethodsThe sample included 12 158 adults with valid HRQoL and BMI data from the 2017 and 2018 Health Survey for England. Robust standard error linear regression, controlling for demographic and socioeconomic characteristics, lifestyle behaviours and obesity‐related comorbidities, was used for the baseline analysis. Robustness checks assessed the impact of (a) estimator selection; (b) model specifications; (c) statistical outliers at high BMI; (d) potential BMI measurement error; and (e) data pooling.ResultsThe study found a significant association between HRQoL and BMI, which exhibited an inverted U‐shaped relationship. The mean HRQoL peaked at 25.7 kg/m2 in men and 22.6 kg/m2 in women and was reduced in the underweight, overweight and obesity BMI ranges. Sensitivity analyses reported similar coefficients, suggesting a robust model specification.ConclusionsReduced HRQoL beyond optimal BMI underlines the importance of maintaining a normal BMI range for overall health. The rising prevalence of class III obesity is a major public health concern given its disproportionate impact on health, health care utilization and costs. Obesity management is key to preventing the reduction in HRQoL associated with obesity‐related comorbidities, and this analysis supports the development of targeted policies and population health initiatives for people with class III obesity.
Perceived changes in transformational leadership: The role of motivation and perceived skills in educational leadership training under an EU‐China cooperation project
Authors: Cheng Zhao , Zhu Chang , Dinh Ngoc Bich Khuyen 
Published: March 2024

AbstractThis study aims to examine the relationship among motivation for joining an educational leadership training programme (MOT), perceived skills (PS), and perceived changes in transformational leadership (PCTFL) in educational leadership training. The study drew on survey data from 761 participants who were associated with a leadership development programme under an EU‐China cooperation project. The conceptual model was tested by structural equation modelling (SEM) by the Mplus programme. MOT and PCTFL were measured, respectively, by second‐order factor structure assessments due to their multi‐dimensional nature. The findings of the study suggest that motivation positively influences perceived changes in transformational leadership, and this relationship is positively mediated by perceived skills as learning gains in educational leadership training. The study provides novel empirical evidence on motivation that leads to transformational leadership changes in leadership training programmes. Policymakers and other key stakeholders can use these findings to gain a deeper understanding of the success of projects and encourage academic members to participate in leadership training programmes to improve transformational leadership.
Unlocking the potential of research‐informed practice: Insights into benefits, challenges, and significance among teachers in Catalonia, Poland, and England
Authors: Ion Georgeta , Kowalczuk‐Walędziak Marta , Brown Chris 
Published: March 2024

AbstractThis survey‐based study delves into the intricate interplay of research utilisation in the pedagogical approaches of a sample of 534 teachers across Catalonia (Spain), Poland, and England. Applying Baudrillard's Theory of Consumption lenses, we present novel insights into the multifaceted aspects of research use, including its benefits, costs, and significance within the teaching profession. Our findings underscore the interdependencies among the perceived benefits, costs, and significance of research utilisation, bolstered by factor analysis. Specifically, our results indicate that teachers regard research as a means to enhance their understanding of educational theories, providing valuable insights to inform their teaching practices. Moreover, research empowers teachers to challenge entrenched conceptions and adopt innovative pedagogical strategies. In addition, the significance of research use is associated with its alignment with school priorities and integration into the decision‐making processes. Furthermore, teachers identified various obstacles to research use, including issues of research literacy, support mechanisms, and the accessibility of research resources. The study sheds additional insight into the dynamics of research utilisation among teachers operating within diverse national contexts. It underscores the intricate relationships between individual and organisational factors that shape and influence teaching practices.
Energizing a literature review to boldly go where no one has gone before
Authors: Craighead Christopher W. , Ketchen David J. 
Published: March 2024

AbstractTaking stock of a research stream through a literature review can provide tremendous value. Whether this potential is fully realized depends on the degree to which the review energizes a research stream by setting a course toward exploration of compelling and exciting research questions. The purpose of this editorial is twofold. First, we describe four key tactics that scholars can use to create an energizing literature review: (1) launching research ideas from the conceptual platform built by the review; (2) ripping cutting‐edge research ideas from news and industry headlines; (3) unveiling a portfolio of theoretical opportunities; and (4) constructing an accessible research agenda. Second, we introduce the five literature reviews contained in this special topic forum with particular attention to their energizing features.