bluuebunny/crossref_metadata_2025_split huggingface dataset:
9H‐Xanthene‐9‐carboxylic Acid [1,2,4]Oxadiazol‐3‐yl‐ and (2H‐Tetrazol‐5‐yl)‐amides as Potent, Orally Available mGlu1 Receptor Enhancers.
Authors: Vieira Eric , Huwyler Joerg , Jolidon Synese , Knoflach Frederic , Mutel Vincent , Wichmann Juergen 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Exchange Bias in Ferromagnetic Nanoparticles Embedded in an Antiferromagnetic Matrix
Authors: Nogues J. , Sort J. , Langlais V. , Doppiu S. , Dieny B. , Munoz J. S. , Surinach S. , Baro M. D. , Stoyanov S. , Zhang Y. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Stable Heteroaromatic Carbenes of the Benzimidazole and 1,2,4‐Triazole Series
Authors: Korotkikh Nikolai I. , Shvaika Oles P. , Rayenko Gennady F. , Kiselyov Artyom V. , Knishevitsky Arthur V. , Cowley Alan H. , Jones Jamie N. , Macdonald Charles L. B. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A retrospective comparison of three sequential groups of patients with Recurrent/Refractory chronic lymphocytic leukemia treated with fludarabine‐based regimens
Authors: Wierda William , O'Brien Susan , Faderl Stefan , Ferrajoli Alessandra , Wang Xuemei , Do Kim‐Anh , Garcia‐Manero Guillermo , Thomas Deborah , Cortes Jorge , Ravandi‐Kashani Farhad , Giles Francis , Lerner Susan , Kantarjian Hagop , Keating Michael 
Published: December 2005

AbstractBACKGROUNDCombining therapeutics with single‐agent activity has improved treatment for patients with many malignancies. Debate continues about the impact of treatment on survival in patients with chronic lymphocytic leukemia (CLL). Purine analogues are the most active agents for treatment of patients with CLL. Recently, it was shown that a chemoimmunotherapy regimen combining fludarabine (F), cyclophosphamide (C), and rituximab (R) (FCR) was very effective in treating patients with recurrent and/or refractory CLL. The objective of the current analysis was to determine whether improvements in treatment have had an impact on survival for patients with CLL.METHODSThree nonoverlapping, sequential groups of patients enrolled on Phase II studies who received treatment with F (n = 251 patients), FC (n = 111 patients), or FCR (n = 143 patients) were analyzed. Pretreatment characteristics, responses to treatment, and overall survival were compared.RESULTSPatients who were treated with FCR had a higher complete remission rate compared with patients who were treated with combined F and C or with F alone. Statistically significantly longer estimated median survival was noted for patients who received FCR. A Cox proportional hazards, multivariable model for overall survival that included all patients (n = 505) showed that patients who received FCR had longer survival (P < 0.0001) after adjusting for other significant (P < 0.05) pretreatment characteristics, including age, hemoglobin, β‐2 microglobulin, and the number of prior treatments.CONCLUSIONSThe results of this retrospective comparison of patients with recurrent and refractory CLL indicated a higher complete remission rate and the longest estimated survival for patients who were treated with FCR, providing the basis for randomized clinical trials of this regimen. Cancer 2006. © 2005 American Cancer Society.
Efficacy of caspofungin against invasive Candida or invasive Aspergillus infections in neutropenic patients
Authors: Betts Robert , Glasmacher Axel , Maertens Johan , Maschmeyer Georg , Vazquez Jose A. , Teppler Hedy , Taylor Arlene , Lupinacci Robert , Sable Carole , Kartsonis Nicholas 
Published: December 2005

AbstractBACKGROUNDNeutropenia is an indicator of poor prognosis in patients with fungal infections. All available clinical trial experience from the caspofungin development program was reviewed to ascertain the efficacy of caspofungin in neutropenic patients with documented invasive aspergillosis (IA) or invasive candidiasis (IC).METHODSThe review was limited to neutropenic patients with proven IC or proven/probable IA at caspofungin onset. Data were available from four clinical trials. All patients had an absolute neutrophil count < 500/mm3 at the initiation of caspofungin. In all cases caspofungin was administered as monotherapy at a dose of 50 mg/day, after a 70‐mg loading dose. In all patients efficacy was assessed at the completion of caspofungin therapy. Success included complete and partial responses.RESULTSSixty‐eight neutropenic patients were identified with documented invasive infection, including 27 with IC and 41 with IA. Most patients had acute or chronic leukemia. A favorable response was noted in 63% (17 of 27 patients) of patients with IC, including a 58% (14 of 24 patients) response as first‐line therapy and a 100% (3 of 3 patients) response as salvage therapy. Success in candidemia was 68% (17 of 25 patients). Outcomes across the different Candida species were similar. Favorable responses were noted in 39% (16 of 41 patients) of patients with IA, including a 42% (5 of 12 patients) response as first‐line therapy and 38% (11 of 29 patients) response as salvage therapy. Success by site of IA was 40% for pulmonary (12 of 30 patients), 43% for sinus (3 of 7 patients), and 25% for skin/disseminated site (1 of 4 patients).CONCLUSIONSA review of the caspofungin database demonstrates that this echinocandin is effective in neutropenic patients with documented cases of IC or IA. Cancer 2006. © 2005 American Cancer Society.
The preoperative erythrocyte sedimentation rate is an independent prognostic factor in renal cell carcinoma
Authors: Sengupta Shomik , Lohse Christine M. , Cheville John C. , Leibovich Bradley C. , Thompson R. Houston , Webster W. Scott , Frank Igor , Zincke Horst , Blute Michael L. , Kwon Eugene D. 
Published: December 2005

AbstractBACKGROUNDPrognostic nomograms are used increasingly in clinical trials and to guide surveillance for patients with renal cell carcinoma (RCC). An elevated erythrocyte sedimentation rate (ESR) reportedly has been associated with a poor prognosis among patients with RCC, but the ESR is not incorporated into existing nomograms. Hence, the current study was conducted to expand on prior observations pertaining to the ESR as a prognostic indicator in patients with RCC.METHODSThe authors identified 3008 patients who underwent nephrectomy for RCC between 1970 and 2002. Disease‐specific survival was estimated using the Kaplan–Meier method, and its association with the ESR and other clinical and pathologic features was evaluated using Cox proportional hazards regression analysis.RESULTSA preoperative ESR was available for 1075 patients (35.7%), 501 of whom (46.6%) exhibited an elevated ESR, including 437 of 881 patients (49.2%) with clear cell RCC, 41 of 134 patients (30.6%) with papillary RCC, and 20 of 48 patients (41.7%) with chromophobe RCC. An elevated ESR was associated with adverse clinical, laboratory, and pathologic profiles for all three histologic subtypes. The risk ratios (RRs) and 95% confidence intervals (95% CIs) for death because of clear cell RCC, papillary RCC, and chromophobe RCC for patients with an elevated ESR were 3.6 (95% CI, 1.1–1.9), 3.8 (95% CI, 1.4–10.6), and 10.3 (95% CI, 1.2–89.5), respectively. The association between an elevated ESR and death from clear cell RCC persisted even after multivariate analysis (RR of 1.5; 95% CI, 1.2–2.0).CONCLUSIONSAn elevated ESR in patients with RCC suggested the presence of aggressive disease and poorer outcomes after surgical treatment. For patients with clear cell RCC, the ESR provided useful information above and beyond traditional prognostic algorithms, and it may be valuable for preoperative prognostication. Cancer 2006. © 2005 American Cancer Society.
Calcium plus vitamin D alters preneoplastic features of colorectal adenomas and rectal mucosa
Authors: Holt Peter R. , Bresalier Robert S. , Ma Chan K. , Liu Kai‐Feng , Lipkin Martin , Byrd James C. , Yang Kan 
Published: December 2005

AbstractBACKGROUNDCalcium and vitamin D are chemopreventive agents for colorectal neoplasia. Studies of the effects of calcium and vitamin D on early surrogate markers of reduced risk, such as proliferation, have been limited to evaluation of the flat colorectal mucosa. Biologic changes that may occur in colorectal adenomas after chemopreventive regimens have not been reported.METHODSIn the current study, adenomatous polyps were transected, approximately 50% were removed for histologic examination, and the remnants tattooed before the administration of either calcium carbonate (1500 mg 3 times daily) plus vitamin D3 400 IU or a placebo for 6 months. At study end, polyp remnants were resected completely and were used for histologic examination. Immunohistochemical staining was performed in both flat mucosa and in polyp tissue. Proliferation was assessed by MIB‐1 staining; apoptosis was assessed by terminal deoxyuridine triphosphate‐biotin nick‐end labeling, BAK, and Bcl‐2 staining; and cytokeratin AE1, vitamin D receptor, MUC5AC mucin, and galectin‐3 were assessed by immunohistochemisty.RESULTSNineteen patients, including 11 patients in the treatment group and 8 patients in the control group, completed the study. Proliferative indices fell both in flat mucosa and in polyps in the treatment group, and there were no significant changes in the control group. Apoptosis and Bcl‐2 immunostaining were unchanged in both groups, but the frequency of BAK‐immunostained cells in the interior of polyps rose significantly. Vitamin D receptor staining increased slightly and significantly in flat rectal tissue in the treatment group. There were no significant changes in galectin‐3 staining, but a striking reduction in MUC5AC mucin staining in polyps was observed after treatment with calcium plus vitamin D.CONCLUSIONSThe administration of a calcium plus vitamin D chemopreventive regimen resulted in several changes in adenomatous tissue that may have contributed to reduced polyp formation. Cancer 2006. © 2005 American Cancer Society.
Metaanalysis of the correlation between radiographic tumor response and patient‐reported outcomes
Authors: Victorson David , Soni Mehul , Cella David 
Published: December 2005

AbstractBACKGROUNDThe primary aim of the current study was to determine whether radiographic tumor response is associated with patient‐reported outcomes such as symptom response or health‐related quality of life.METHODSA metaanalysis was conducted of 21 available studies from 1995–2003 that provided data sufficient for examining the association between tumor response and patient‐reported outcomes, including symptom response and health‐related quality of life. A second aim was to examine the influence of possible moderating study variables on effect size variation.RESULTSAs hypothesized, patient‐reported outcome improvement rates were most frequently associated with patients classified as a complete or partial response (CR/PR), followed by those with stable disease (SD) and progressive disease (PD). Moderate effect sizes were observed between the CR/PR and SD (effect size of 0.35) and CR/PR and PD categories (effect size of 0.43). A weak effect size was found between SD and PD (effect size of 0.16), raising concern over the meaningfulness of the SD category. No significant correlations were found between effect size and patient or study characteristics. Significant associations existed between treatment duration and age, study duration, survival, and symptom response rates, especially among PD patients.CONCLUSIONDespite significant study‐to‐study heterogeneity, an important association exists in the correlation between tumor response and formal measures of change in patient‐reported outcomes. A better understanding of this relation would be enhanced if future reports included estimates of effect size in patient‐reported outcome change by tumor response category. Practical implications, limitations, and directions for future research are provided. Cancer 2006. © 2005 American Cancer Society.
Expression of the Bax inhibitor‐1 gene in pulmonary adenocarcinoma
Authors: Tanaka Ryota , Ishiyama Tadashi , Uchihara Teruhito , Inadome Yukinori , Iijima Tatsuo , Morishita Yukio , Kano Junko , Goya Tomoyuki , Noguchi Masayuki 
Published: December 2005

AbstractBACKGROUNDThe regulation of programmed cell death, or apoptosis, is crucial for normal development and for the maintenance of homeostasis. It has been shown that the novel antiapoptotic protein Bax inhibitor‐1 (BI‐1) represents a new type of regulator of cell death pathways controlled by Bcl‐2 and Bax.METHODSSurgically resected lung specimens were obtained from 32 patients with peripheral adenocarcinomas, and BI‐1 gene expression was examined and compared with expression of the p53, bcl‐2 and Bax genes.RESULTSFourteen of 32 tumors (43.8%) were positive for BI‐1 gene expression by in situ hybridization. BI‐1 gene expression in tumor specimens was significantly higher in adenocarcinomas with bronchioloalveolar carcinoma (BAC) and in adenocarcinomas of mixed subtypes with bronchioloalveolar spreading (14 of 17 tumors; 82.4%) than in carcinomas without it spreading. Patients who had BI‐1‐positive adenocarcinoma showed a relatively favorable prognosis compared with patients who had BI‐1‐negative adenocarcinoma. Eleven of 32 tumors (34.4%) were positive for the p53 protein, only 1 of 32 tumors (3.1%) was positive for the Bcl‐2 protein, and 26 of 32 tumors (81.3%) were positive for the Bax protein. Protein expressions of p53, Bcl‐2, and Bax, as detected by immunohistochemistry, were not associated with BI‐1 gene expression.CONCLUSIONSBI‐1 gene expression was restricted to tumor cells with lepidic growth and was a prognostic factor for peripheral‐type adenocarcinoma. It is believed that BI‐1 gene expression is conserved evolutionarily and may act as a key regulator of the apoptotic pathway in BAC. Cancer 2006. © 2005 American Cancer Society.
Optimal shape design for blade's surface of an impeller via the Navier–Stokes equations
Authors: Li Kaitai , Su Jian , Gao Limin 
Published: December 2005

AbstractIn this paper, a new principle of geometric design for blade's surface of an impeller is established. This is a thorough mathematical investigation of a shape control problem for the optimal design of an impeller's blade while 3D rotating Navier–Stokes equations are as the state equations in the control problem. The objective is to design the blade such that the viscous drag is minimized. Establishing a new curvilinear coordinate system, we depart from a standard domain transformation commonly used in the engineering literature and utilizing it we rephrase the design problem in one on a fixed domain. Certain advantages of our approach as no need for mesh regeneration and node redistribution and 3D mesh quality improvement are evident. Furthermore, in new coordinate system, it is easy to obtain gradient of optimal functional with respect to the surface of blade and to derive Euler–Lagrange equations for optimal solution which is an elliptic boundary value problem of fourth order. Moreover, we give the conjugate gradient algorithm for the control problem. Copyright © 2005 John Wiley & Sons, Ltd.
What makes workflows work in an opportunistic environment?
Authors: Deelman Ewa , Kosar Tevfik , Kesselman Carl , Livny Miron 
Published: December 2005

AbstractIn this paper, we examine the issues of workflow mapping and execution in opportunistic environments such as the Grid. As applications become ever more complex, the process of choosing the appropriate resources and successfully executing the application components becomes ever more difficult. This may include extension or reduction of the initial workflow mapping as necessary for the actual execution. In this paper, we focus on the interplay between a workflow‐mapping component that plans the high‐level resource assignments and the workflow executor that oversees the component execution. We concentrate particularly on issues of data management and we draw from the experiences with mapping and execution systems: Pegasus, DAGMan and Stork. Copyright © 2005 John Wiley & Sons, Ltd.
Implementing BPEL4WS: the architecture of a BPEL4WS implementation
Authors: Curbera Francisco , Khalaf Rania , Nagy William A. , Weerawarana Sanjiva 
Published: December 2005

AbstractBPEL4WS (BPEL in short) is a business process definition language built natively on top of the Web services application model. BPEL provides a workflow‐oriented composition model for Web services applications, and is thus a central piece in the heavily componentized service‐oriented computing model. BPEL results from the merger of two distinct process metamodels (the process algebra model of XLANG and the graph‐oriented model of WSFL) into a coherent and powerful framework. Implementing BPEL thus presents significant challenges to middleware developers. This paper discusses those challenges and describes the design and architecture of the BPWS4J runtime, and a full implementation of the BPELWS 1.1 specification. Copyright © 2005 John Wiley & Sons, Ltd.
ScyFlow: an environment for the visual specification and execution of scientific workflows
Authors: McCann Karen M. , Yarrow Maurice , DeVivo Adrian , Mehrotra Piyush 
Published: December 2005

AbstractWith the advent of Grid technologies, scientists and engineers are building more complex applications to utilize distributed Grid resources. Core Grid services provide a path for accessing and utilizing these resources in a secure and seamless fashion. However, what the scientists need is an environment that will allow them to specify their application runs at a high organizational level, and then will support efficient execution across any given set or sets of distributed resources. We have been designing and implementing ScyFlow, a dual‐interface architecture, both Graphical User Interface (GUI) and Application Programming Interface (API), that addresses this problem. The scientist/user specifies the application tasks along with the necessary control and data flow, and then monitors and manages the execution of the resulting workflow across the distributed resources. In this paper, we utilize two scenarios to provide the details of the two modules of the project, the visual editor and the runtime workflow engine. Published in 2005 by John Wiley & Sons, Ltd.
A Prime Example of Hard‐Hard and Soft‐Soft Interactions: Complexes between 4,7‐Dioxa‐1,10‐diazabicyclo[8.6.6]docosa‐13,19‐diyne and Li+, Na+, Cu+, Ag+, Cd2+, Hg2+
Authors: Kunze Andreas , Gleiter Rolf , Rominger Frank 
Published: December 2005

AbstractThe crystal structures of 4,7‐dioxa‐1,10‐diazabicyclo[8.6.6]docosa‐13,19‐diyne (7), its N,N′‐dioxide derivative 10 and the complexes of 7 with LiClO4, NaNO3, CuI and AgI triflate, Cd(NO3)2, and HgCl2 were investigated. The Li+ and Na+ ions reveal a strong interaction between the ether bridge and the nitrogen atoms of 7. The CuI ion prefers an interaction between the nitrogen centers and the alkyne units whereas the AgI ion interacts with the hard oxygen and nitrogen centers as well as with the alkyne units. The reaction of HgCl2 with 7 in the presence of water afforded a molecule which could be looked at as the intermediate of a mercury‐catalyzed addition of water to the triple bonds. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Hydride Transfer Reactivity of Mo(L)(H)(depe)2 (L = N, NBEt3)
Authors: Cugny Johan , Schmalle Helmut W. , Fox Thomas , Blacque Olivier , Alfonso Montserrat , Berke Heinz 
Published: December 2005

AbstractStarting from Mo(N2)2(depe)2 (1), the nitrido complex Mo(N)(N3)(depe)2 (2) was obtained by the reaction of 1 with Me3SiN3. Subsequent reaction of 2 with HCl in CH3OH afforded the cationic imido chloride 3, which could be converted into the nitrido chloride 4 with sodium bis(trimethylsilyl)amide. From 3 and 4 the hydrido complexes of the type Mo(H)(L)(depe)2 [L = N (7), NBEt3 (8)] were obtained by the reaction with the hydride reagents LiBH4 and NaHBEt3. The hydridic character of the LnM–H bond of 8 was determined by DQCC measurements (bond ionicity i = 81 %). Hydride reactivity studies were carried out on 7 and 8; however, only 8 underwent hydride transfer reactions. 8 reacted with 4,4′‐dichlorobenzophenone and acetophenone to afford the corresponding alkoxide complexes Mo(NBEt3)(OCHRR′)(depe)2 [R, R′ = C6H4Cl (10); R = Me, R′ = Ph (11)]. The high propensity of 8 to undergo carbonyl insertion was documented further by reactions with CO2 and carbonylmetal compounds. Conversion with CO2 led to formation of the formato complex Mo(NBEt3)(OCHO)(depe)2 (9) and reactions with Fe(CO)5 and Re2(CO)10 resulted in the formation of Mo[(μ‐OCH)Fe(CO)4](NBEt3)(depe)2 (12) and Mo[(μ‐OCH)Re2(CO)9](NBEt3)(depe)2 (13). X‐ray diffraction studies were carried out on 1–4, 6, 8–10 and 12–14. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
The First Coordination Polymers Based on Octahedral Hexahydroxo Rhenium Cluster Complexes [Re6Q8(OH)6]4– (Q = S, Se) and Alkaline Earth Metal Cations
Authors: Mironov Yuri V. , Fedorov Vladimir E. , Bang Hyunjin , Kim Sung‐Jin 
Published: December 2005

AbstractSeven novel octahedral cluster compounds [{Mg(H2O)5}2Re6S8(OH)6]·6H2O (1), [{Ca(H2O)3}2Re6S8(OH)6] (2), [{Ca(H2O)3}2Re6Se8(OH)6] (3), [{Sr2(H2O)10}Re6S8(OH)6]·6H2O (4), [{Sr2(H2O)10}Re6Se8(OH)6]·6H2O (5), [{Ba2(H2O)8}Re6S8(OH)6] (6), and [{Ba2(H2O)8}Re6Se8(OH)6] (7) were prepared by the direct reaction of K4[Re6S8(OH)6]·8H2O and K4[Re6Se8(OH)6]·8H2O with the cations of the elements of main group II. All compounds have been characterized by single crystal X‐ray diffraction. Compound 1 has a discrete molecular structure, compounds 4 and 5 have a one‐dimensional chain structure, and compounds 2, 3, 6, and 7 crystallize in two different types of two‐dimensional layered structure. This sulfur containing series has been characterized by luminescent spectroscopy. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Platinum‐Group Chelate Complexes with 9‐Hydroxyphenalenone Derivatives: Synthesis, Structures, Spectroscopic Properties and Cytotoxic Activities
Authors: Mochida Tomoyuki , Torigoe Reiko , Koinuma Takeo , Asano Chika , Satou Tadaaki , Koike Kazuo , Nikaido Tamotsu 
Published: December 2005

AbstractThe following platinum‐group chelate complexes with 5‐R‐9‐hydroxyphenalenone (L1: R = H; L2: R = Me; L3: R = Pr) have been prepared: [RhI(L)(CO)2] (1a: L = L1; 1b: L = L2; 1c: L = L3), [PdII(L)2] (2a: L = L2; 2b: L = L3), [PtII(L1)(NH3)2](NO3) (3), and (Bu4N)[PtII(L1)(Cl)2] (4). Compounds 1a and 1b are different colors in the solid state: yellow and deep red, respectively. X‐ray analysis revealed that 1a has a regular π–π stacking structure while 1b has a dimer‐like arrangement with a RhI–RhI distance of 3.2336(6) Å. Both solids were luminescent at 77 K. Compounds 2a and 2b are planar extended π‐conjugated complexes, which exhibit two‐dimensional stacking modes in the crystal. The solid‐state structure of complex 3 is hydrogen‐bonded in a polar arrangement. The cytotoxic activities of 1a, 3, and 4, evaluated in vitro against HL60 human acute myeloid leukemia cell lines, were comparable to that of cisplatin. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)