bluuebunny/crossref_metadata_2025_split huggingface dataset:
ELECTROMYOGRAPHIC ANALYSIS OF MULTIFIDUS MUSCLE ACTIVITY DURING THREE EXERCISES
Authors: Chandna Manan , Sharma Charvi , Rogers Michael E. 
Published: February 2025

https://youtu.be/V-jzFHp4z3Y

INTRODUCTION
The multifidus muscle is integral to spinal stability and posture control. To enhance rehabilitation and training programs, it is essential to understand the patterns of its activation across various exercises. The purpose of this study was to analyze the electromyographic (EMG) activity of the multifidus muscle during three specific exercises: deadlifts, bird-dogs, and single-leg balance exercises, to determine which exercise most effectively activates this muscle.

METHODS
Twenty adults (men: 9; women: 11; age: 24.7 + 2.1 yr; height: 167.9 + 10.8 cm; weight: 73.9 + 15.8 kg (mean+SD)) participated in the study. Surface EMG electrodes were placed bilaterally at the L4-L5 level after skin preparation. Deadlifts (5 reps at 50% body weight), bird-dog held for 10 sec on each side while holding a 2.27 kg weight in the outstretched hand, and single-leg stance held for 10 sec on each foot were performed under supervision in a randomized order. EMG data (max amplitude) were recorded with each session lasting ~15 minutes. Data were analyzed to compare muscle activation patterns across exercises.

RESULTS
EMG activity showed significant (p&lt;0.05) differences across exercises with deadlifts inducing the highest mean muscle activation (0.949 + 0.623 mV), followed by bird-dog right (0.370 + 0.173 mV) and bird-dog left (0.352 + 0.161 mV). The single-leg balance exercises elicited the lowest mean muscle activations, both for the right (0.124 + 0.049 mV) and left sides (0.134 + 0.068 mV). There were no bilateral differences for any of the exercises.

CONCLUSIONS
The multifidus muscle showed varying levels of activation across different exercises, with the highest activation during deadlifts and the lowest during single-leg balance tasks. The deadlifts elicited a significantly stronger muscle response compared to balance exercises, suggesting that weight-bearing exercises might be more effective for multifidus muscle activation. The findings suggest that rehabilitation programs that include deadlifts could potentially offer greater benefits for improving core stability and reducing back pain.
TELEHEALTH PROGRAM CREATES EXERCISE HABIT FOR NON-ADHERENT PATIENT WITH ORTHOSTATIC INTOLERANCE
Authors: Rossi Shannon , Ward Kendra , Myers Jillian , Raymond Cassandra , McMahon Melissa , Holst Brittany 
Published: February 2025

INTRODUCTION
Orthostatic Intolerance (OI) impacts patients’ ability to perform activities of daily living (ADLs) often leading to symptom exacerbation and significant deconditioning over time. Exercise aids symptom control by increasing cardiac output and venous return. Creating and maintaining an exercise routine often requires additional supports.

CASE PRESENTATION
A 15-year-old female was referred for a 6-month history of postural dizziness and presyncope. At the initial clinic visit, orthostatic testing was completed which showed a 27-bpm increase in heart rate. Baseline ECG showed sinus rhythm with normal intervals and review of systems was unremarkable. Patient history, symptoms and testing were noted to be consistent with OI. Initial interventions included general exercise resources and education materials, such as a daily aerobic walking plan (begin with 5-minute duration and increase by 5 minutes/week until 60 minutes total is achieved per day). Quarterly to bi-yearly clinic follow-ups showed no improvement in symptoms, despite reinforcing exercise recommendations and education at each visit. Follow up repeat testing, predicted aerobic capacity assessment, muscular endurance assessment, and surveys were completed. Exercise physiologist (ExP) initiated telehealth exercise sessions.

OUTCOME
Prior to intervention, patient physical activity consisted of walking at work. ExP conducted eleven telehealth exercise sessions over a 3-month period (30 min duration, 2 times/week). Sessions included education on form, safety, exercise components, & intensity progression. Resistance exercises were completed with real-time supervision and feedback. Following completion of the telehealth program, testing showed decrease in symptom severity (-110%), increase in predicted aerobic capacity (+28%), maintenance of lower extremity muscular endurance (-6%), decrease in fatigue (-62%), and maintenance of mobility (-27%). One month post completion of telehealth intervention patient remained adherent to exercise prescription of aerobic exercise (2 times/week) & strength training (2 times/week).

DISCUSSION
Early clinic education emphasized the importance of exercise for this patient; however, neither education nor clinic resources resulted in adherence to an exercise routine. Virtually delivering high quantity, synchronized exercise sessions, allowed the patient to experience improvement in functional capacity and reduction in symptom intensity. Virtual delivery of exercise medicine sessions can be applied to multiple clinical conditions and wider delivery to varied patient populations should be explored.
INTER-INDIVIDUAL RESPONSE DIFFERENCES ON CARDIORESPIRATORY FITNESS IN HEART FAILURE
Authors: Kelley George A. , Kelley Kristi S. , Stauffer Brian L. 
Published: February 2025

https://youtu.be/wu8t-3F-vJc

BACKGROUND
Previous studies have shown an association between low cardiorespiratory fitness (CRF) and mortality in adults with heart failure with preserved ejection fraction (HFpEF). While exercise-based cardiac rehabilitation (EBCR) has been reported to increase CRF in adults with HFpEF, true inter-individual response differences (IIRD) to EBCR among those with HFpEF is not known nor has it ever been assessed. The purpose of this study was to address this gap.

METHODS
Using data from the recent American Heart Association and American College of Cardiology statement on supervised exercise training for chronic HFpEF, eight randomized controlled trials representing 503 adults (260 exercise, 243 control) were included and pooled for a standard deviation of individual response (SDIR) meta-analysis on changes in CRF, assessed as VO2peak in mL.kg-1min-1. The inverse heterogeneity (IVhet) model was used to pool results.

RESULTS
The pooled 95% confidence interval (CI) for the SDIR included zero (mean, 0.5, 95% CI, -1.9 to 2.0 mL.kg-1min-1). With each study deleted from the model once, results continued to not reach statistical significance. The 95% prediction interval for the SDIR, indicative of what result one might expect is they conducted their own randomized controlled trial, was -3.3 to 3.3 mL.kg-1min-1. The probability of a clinically meaningful difference of at least 1.0 mL.kg-1.min-1 in VO2peak was 50.6% (only possibly clinically important).

CONCLUSION
There is a lack of exercise-associated IIRD on VO2peak in adults with HFpEF once random and within-subject variation are properly accounted for. Thus, a search for potential moderators and mediators, including genetic interactions, on VO2peak in adults with HFpEF cannot be supported at this time.
¿Cómo determinan la convergencia de una serie numérica los estudiantes? Un análisis de sus argumentos
Authors: Rosas Mendoza Alejandro Miguel , Ramírez Oviedo Luis Fernando , Molina Zavaleta Juan Gabriel 
Published: February 2025

Introducción: Este trabajo tuvo como finalidad analizar las características de los argumentos de estudiantes mientras resuelven tareas matemáticas sobre la convergencia o divergencia de series numéricas infinitas. Estudiar los argumentos de los estudiantes permite revisar su razonamiento y su comprensión de las series numéricas. Metodología: Para estudiar los argumentos de los estudiantes se utilizó el modelo argumentativo de Toulmin, el cual ha sido utilizado en el estudio de diferentes formas de argumentación y en múltiples contextos. La investigación es de corte cualitativo para lo cual se construyeron tablas de cotejo para analizar la estructura de los argumentos y caracterizarlos. Resultados: Se aplicaron dos actividades de 3 series numéricas infinitas para que los alumnos determinaran su convergencia o divergencia, se recopilaron datos escritos y audios con las respuestas y justificaciones. Discusión: Los argumentos incluyen diferentes elementos de los que el modelo de Toulmin establece. Conclusiones: Entre las conclusiones obtenidas, se encontró que los estudiantes basan su argumentación en los criterios de convergencia de las series, este constituye su punto de partida para desarrollar su proceso argumentativo sin considerar, en muchos casos, los datos presentes en la actividad o tarea matemática.
Literature Review: Immersive Technology as a Teaching Aid in the Health Sector
Authors: Mutyara Dehana , Adisusilo Anang Kukuh , Abdillah Bima Ahmad Perkasa 
Published: February 2025

The increasing complexity of healthcare education and the limitations of traditional teaching methods necessitate innovative approaches to meet global demands for skilled professionals. Immersive technologies, including Virtual Reality (VR), Augmented Reality (AR), Mixed Reality (MR), and Extended Reality (XR), offer transformative potential by providing interactive, lifelike simulations that bridge theoretical knowledge and practical skills. This study employs a systematic literature review alongside case studies and interviews with educators and students to assess the effectiveness of these technologies in healthcare training. Results reveal significant improvements in learner engagement, conceptual understanding, skill acquisition, and empathy, with particular benefits for inclusive and adaptive learning. However, barriers such as high costs, accessibility challenges, and ethical concerns persist, limiting widespread implementation. Practical recommendations are proposed to overcome these challenges through scalable, cost-effective solutions and interdisciplinary collaboration. This research highlights the global potential of immersive technologies to revolutionize healthcare education, fostering equity, inclusivity, and the development of a competent and empathetic healthcare workforce.
Intelligence Book Recommendation System Using Collaborative Filtering
Authors: Nabilah Nisa , Zanariah Zanariah 
Published: February 2025

The rapid growth of online literary material has changed the way users discover books, revealing the limitations of traditional recommendation algorithms. This paper presents a review about an intelligent book recommendation system that uses collaborative filtering (CF) and artificial intelligence techniques to address major obstacles such as cold-start issues, data scarcity, and privacy concerns. The suggested method guarantees customized, accurate, and diversified recommendations by merging hybrid approaches such as CF with content-based filtering and matrix factorization. To measure performance, the researchers employ publicly accessible datasets, rigorous preprocessing approaches, and assessment criteria like as accuracy, recall, and F1-score. This project intends to rethink the book discovery process by solving basic issues and applying a privacy-conscious design, while also providing a scalable and user-friendly platform for tailored recommendations.
Ejercicios físicos, equilibrio e inclusión: una experiencia con estudiantes con discapacidad auditiva
Authors: Ermel Caicedo Josué , Uriarte Albán Yadira del Carmen , Maqueira Caraballo Giceya de la Caridad 
Published: February 2025

Introducción. La inclusión de estudiantes con discapacidad auditiva en la clase de educación física implica la mejora de su equilibrio y la realización de ejercicios adaptados. Objetivo. Diseñar ejercicios físicos adaptados para compensar los problemas de equilibrio y la mejora de la inclusión de estudiantes con discapacidad auditiva en las clases de educación física. Metodología. En el estudio se empleó un enfoque mixto no experimental, de tipo exploratorio secuencial, de alcance descriptivo. Para su desarrollo se establecieron tres etapas: diagnóstico, diseño y validación, apoyado en métodos teóricos dentro de estos el analítico- sintético, inductivo -deductivo y la modelación, como métodos empíricos se empleó la observación directa, entrevista y la medición, apoyado en técnicas como la guía de observación, la guía de entrevista, la revisión documental y la escala de equilibrio de Berg. La muestra fue no probabilística seleccionándose de manera intencional como unidad de análisis 11 estudiantes entre 7 y 9 años que presentaban diferentes grados de discapacidad auditiva. Para la validación de la propuesta, se utilizó el criterio de especialista mediante un taller de socialización. Resultados. Quedó evidenciado que los estudiantes con discapacidad auditiva enfrentan desafíos significativos en el proceso de inclusión en la clase de educación física, especialmente en la realización de actividades que requieren equilibrio y coordinación. Los estudios precedentes y opiniones de los especialistas consultados destacan la valía de los ejercicios adaptados en entornos diversos (agua, superficies inestables y tierra firme), señalando que pueden ser eficaces para mejorar el equilibrio, aspecto crítico para su inclusión activa en las clases. Conclusiones. Los ejercicios físicos adaptados contribuyen a la mejora del equilibrio de los estudiantes con discapacidad auditiva, resultando altamente importantes para estimular su proceso de inclusión a las clases de educación física y promover un entorno educativo equitativo, respetuoso e inclusivo. Área de estudio general: Educación. Área de estudio específica: educación física Inclusiva. Tipo de estudio: Artículo de investigación original.
Gene expression changes in blastocyst hatching affect embryo implantation success in mice
Authors: An Liyou , Zhang Liang , Wu Yulin , Teng Yadi , Liu Zihan , Ma Meixiang , Li Miaolong , Peng Xinrong , Liu Chenxi 
Published: February 2025

In mammalian embryonic development, blastocyst hatching is essential for normal implantation and development of the fetus. We reported previously that blastocysts hatching out of the zona pellucida (ZP) exhibited site preferences that were associated with pregnancy outcomes. To characterize these site differences, we analyzed the transcriptomes in the following developing mouse blastocysts within 16 h of hatching: expanding (E), hatching from the A-site (A), B-site (B), and C-site (C), hatched (H), and non-hatching (N). By principal component analysis and hierarchical cluster analysis, we determined that the gene expression profiles of A and B blastocysts, which resulted in good fertility, clustered closely. C and N blastocysts, which resulted in poor fertility, clustered closely, but distantly from A and B. Embryos hatched at B- vs. C-sites, with good vs. poor pregnancy, showed 178 differentially expressed genes (DEGs), mainly involved in immunity, which correlated positively with birth rate. These DEGs were primarily regulated by transcription factors TCF24 and DLX3. During blastocyst hatching, immune-related genes were regulated, such as Ptgs1, Lyz2, Il-α, Cfb (upregulated) and Cd36 (downregulated). By immunofluorescence staining, we found C3 and IL-1β on the extra-luminal surface of the trophectoderm of the hatched blastocyst, suggesting that they play a role in maternal-fetal interactions. As the blastocysts developed from the expanding to the fully hatched state, 307 DEGs were either upregulated by transcription factor ATOH8 or downregulated by SPIC to switch on immune pathways. Based on the hatching outcome, we identified three transcription patterns in developing blastocysts, with complex changes in the transcriptional regulation network of failed hatched blastocysts vs. successfully hatched blastocysts. We developed a LASSO regression-based model using DEGs Lyz2, Cd36, Cfb, and Cyp17a1 to predict implantation success. This study revealed the diverse, multidimensional developmental fates of blastocysts during short-term hatching and indicated that the immune properties of the embryo had a major effect on blastocyst hatching outcomes. We suggest that transcriptional changes and their regulation during the development of the preimplantation blastocyst affect implantation. This study contributes to our understanding of the role of transcriptional changes in mammalian embryonic development during hatching and their effect on maternal-fetal interactions.
Electrocardiographic signs of cardiac ischemia at rest and during exercise in patients with COPD traveling to 3,100 m: data from a randomized trial of acetazolamide
Authors: Christen Marla , Buergin Aline , Mademilov Maamed , Mayer Laura , Schneider Simon R. , Lichtblau Mona , Sooronbaev Talant M. , Ulrich Silvia , Bloch Konrad E. , Furian Michael 
Published: February 2025

IntroductionIn patients with chronic obstructive pulmonary disease (COPD), oxygen delivery to the heart may be impaired during travel at altitude. We assessed electrocardiogram (ECG)-derived signs of cardiac ischemia and the effects of preventive acetazolamide therapy in COPD patients traveling to high altitudes.MethodsPatients with COPD [Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) grades 2–3] and a predicted forced expiratory volume in 1 s (FEV1) of 66 ± 11% (mean ± SD), aged 57 ± 8 years, and living &lt;1,000 m were included in this analysis of secondary outcomes from a randomized placebo-controlled double-blind trial (www.clinicaltrials.gov, NCT03156231). Exercise electrocardiograms were recorded at the National Center of Internal Medicine and Cardiology, Bishkek (760 m) and on the day of arrival at the Tuja Ashu high-altitude clinic (3,100 m), Kyrgyzstan. Acetazolamide (375 mg/day) or placebo was administered 24 h before the ascent and during the stay at 3,100 m. The incidence of a post-exercise ST elevation (STE) ≥0.3 mm in aVR (J + 80 ms) was the main outcome.ResultsAt 760 m, 3 of 49 (6%) patients randomized to placebo and 3 of 50 (6%) randomized to acetazolamide showed a post-exercise STE. At 3,100 m under placebo, two (4%) new STEs developed and one (2%) disappeared compared to 760 m (P = 0.564, McNemar’s test). At 3,100 m under acetazolamide, one (2%) new STE developed and two (4%) disappeared compared to 760 m (P = 0.564). No treatment effect was detected (P = 0.242, Fisher’s exact test). The mean difference (95% CI) in STE between post-peak exercise between 3,100 m and 760 m was 0.22 mm (0.06 to 0.39) and 0.09 mm (−0.06 to 0.24) under placebo and acetazolamide therapy [treatment effect, −0.13 mm (−0.35 to 0.08, P = 0.230)], respectively.ConclusionsIn lowlanders with moderate to severe COPD ascending to 3,100 m, no ECG-derived signs of cardiac ischemia emerged neither at rest nor post-exercise and this was not modified by preventive acetazolamide therapy.
The value of sex hormones and sex hormone-binding globulin in metabolic dysfunction-associated fatty liver disease among boys with obesity
Authors: Wang Ying , Yang Shuyi , Zhang Suming , Yang Ye , Li Siqing , Zhang Meiyu , Li Xiaona , Bai Hua , Luo Peiliang , Yuan Yingdi 
Published: February 2025

ObjectiveThis study aims to investigate the relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and sex hormones and sex hormone-binding globulin (SHBG) in boys with obesity.MethodsRetrospective analysis of metabolic indicators and sex hormone levels in boys with obesity who sought medical attention at the First People’s Hospital of Lianyungang City from January 2020 to December 2023. Based on abdominal ultrasound results, they were categorized into a simple obesity group and MAFLD group, and differences between the two groups were compared. Utilizing logistic regression analysis to explore the risk factors for developing MAFLD, and through the construction of Receiver Operating Characteristic (ROC) curves, conducting a preliminary assessment of the diagnostic value for MAFLD.ResultsA total of 155 male children with obesity were included in the study, mean age of 11.07 ± 1.53 years. Children in the MAFLD group had higher levels of height[(159.49 ± 12.73)cm vs.(155.55 ± 10.50)cm], weight[(82.32 ± 18.75)kg vs.(68.28 ± 15.00)kg], BMI[(32.08 ± 4.49)kg/m2 vs.(27.85 ± 4.21)kg/m2],fasting insulin[33.42(24.07,43.93)uIU/ml vs.23.91(15.72,31.52)uIU/ml],HOMA-IR[7.27(5.26,10.71) vs.4.87(3.27,6.86)],fastingC-peptide[1409.00(1175.00,1668.00)pmol/L vs.1020.00(849.05,1303.00)pmol/L], WBC[(7.85 ± 1.80)×109/L vs.(7.15 ± 1.42)×109/L], HbA1c[5.40(5.30,5.70)% vs.(5.30(5.20,5.60)%],ALT[48.00(27.00,80.00)U/L vs.19.00(15.00,26.50)U/L], and AST[31.00(24.00,60.00)U/L vs.21.00(18.50, 26.00)U/L] compared to the simple obesity group (P&lt;0.05). Children in the MAFLD group had lower levels of HDL[(1.05 ± 0.21)mmol/L vs.(1.16 ± 0.26)mmol/L], testosterone [42.41(30.33,143.28)ng/dl vs.125.41(23.41,221.57)ng/dl], and SHBG[13.20(9.10,17.30)nmol/l vs.19.60(13.50,29.85)nmol/l] compared to the simple obesity group (P&lt;0.05). Logistic regression showed that BMI, testosterone, and SHBG were independent risk factors for MAFLD in boys, and ROC curve analysis indicated their potential value in the early diagnosis of MAFLD.ConclusionBMI, testosterone, and SHBG are independent risk factors for the occurrence of MAFLD in boys with obesity. To control the occurrence of MAFLD, it is essential to address the root cause of the high growth rate of obesity. The roles of testosterone and SHBG in MAFLD merit further research.
Clinical inertia and treatment intensification among patients with type ii diabetes mellitus at Debre Tabor comprehensive specialized hospital, Ethiopia: an institutional-based cross-sectional study
Authors: Dagnew Samuel Berihun , Wondm Samuel Agegnew , Yitayew Tarekegn Getachew , Kassaw Abebe Tarekegn , Moges Tilaye Arega 
Published: February 2025

BackgroundPeople with type 2 diabetes mellitus who have clinical inertia often struggle to control their blood sugar levels and do not receive timely treatment intensification. Strict glycemic control has advantages, but many patients with diabetes are unable to reach their target blood sugar levels. The study’s main objective was to determine the prevalence of clinical inertia in patients with type 2 diabetes at Debre Tabor Comprehensive Specialized Hospital(DTCSH) in Ethiopia.MethodsAn institutional based, cross-sectional research design was used at Debre Tabor Comprehensive Specialized Hospital from November 20/2023 to January 30/2024. A structured questionnaire modified from various medical records and literatures were used to gather data. A logistic regression model was also employed after the Hosmer-Lemeshow goodness-of-fit test was checked to find contributing variables to clinical inertia. A threshold of p &lt; 0.05 was considered statistically significant.ResultIn total, 287 samples were included in the research. The occurrences of clinical inertia 31.4% (95%CI: 25.9 - 36.8) were obtained from 90 patients. Aged patients (AOR = 1.103; 95% CI, 1.034 - 1.176; P = 0.003), medication fee (AOR = 4.955; 95% CI, 1.284 - 14.127; P = 0.020), medication nonadherence (AOR = 4.345; 95% CI, 2.457 - 15.537; P = 0.001), increase number of medication (AOR = 4.205; 95% CI, 2.657- 6.655; P ≤ 0.001), poor glycemic control (AOR = 2.253; 95% CI, 1.673 - 3.033; P ≤ 0.001) were more likely to have clinical inertia.ConclusionOne-third of patients experienced clinical inertia. Age, glycemic control, medication non-adherence, treatment fee, and number of medications were found to be strongly correlated with clinical inertia. More precise knowledge of the clinical inertia and the associated therapies is necessary to tackle this issue more effectively.