bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancreatic juice cytology in the diagnosis of intraductal papillary mucinous neoplasm of the pancreas
Authors: Yamaguchi Taketo , Shirai Yoshihiko , Ishihara Takeshi , Sudo Kentarou , Nakagawa Akihiko , Ito Hiroshi , Miyazaki Masaru , Nomura Fumio , Saisho Hiromitsu 
Published: November 2005

AbstractBACKGROUNDThe examination of pancreatic juice cytology could hypothetically contribute to the establishment of a definite diagnosis of malignant intraductal papillary mucinous neoplasm of the pancreas (IPMN), but to the authors' knowledge, its significance has not been confirmed to date. The current study was conducted to assess the diagnostic value of pancreatic juice cytology in IPMN and to examine the usefulness of peroral pancreatoscopy (POPS) in sampling pancreatic juice.METHODSThe study subjects were comprised of 103 patients with IPMN who underwent surgical resection of pancreatic tumors (adenoma in29 patients, borderline in17 patients, carcinoma in situ in 25 patients, and invasive carcinoma in 32 patients). Pancreatic juice was collected with a catheter in 71 patients and by POPS in 32 patients. Patients with pancreatic carcinoma (n = 81) and chronic pancreatitis (n = 76) also were investigated.RESULTSThe cytologic diagnosis was found to be of nondiagnostic value in only one patient with an IPMN, whereas it was of no diagnostic value in 14 of the patients with pancreatic carcinoma (17.3%), a difference that was statically significant (P < 0.001). The location of the IPMN (either in the pancreas or the pancreatic ducts) was not found to significantly affect the diagnostic value of the test. The sensitivity for IPMN was 62.2% when pancreatic juice was collected by POPS, and was 38.2% when it was collected using a catheter. In the case of pancreatic carcinoma, the sensitivity of pancreatic juice cytology was found to be 25.4%, which was significantly lower than that for IPMN when the pancreatic juice was collected by POPS (P < 0.001).CONCLUSIONSPancreatic juice cytology was found to have better diagnostic value in the patients with IPMNs compared with those with pancreatic carcinoma. POPS was found to be useful for the collection of pancreatic juice. Cancer 2005. © 2005 American Cancer Society.
L‐asparaginase as a marker of chemotherapy dose modification in children with acute lymphoblastic leukemia
Authors: Baillargeon Jacques , Langevin Anne‐Marie , Lewis Margaret , Thomas Paul J. , Mullins Judith , Dugan John , Pollock Brad H. 
Published: November 2005

AbstractBACKGROUNDThe objective of the current study was to compare chemotherapy dose modifications in obese (a body mass index [BMI] > 95%) and nonobese (a BMI ≤ 95%) pediatric patients with acute lymphoblastic leukemia (ALL).METHODSThe study cohort was comprised of 199 pediatric patients diagnosed with ALL who were treated at 1 of 2 South Texas pediatric oncology centers between 1990–2000. The relative chemotherapy dose modification during the induction phase of chemotherapy was calculated as the ratio of 1) the actual administered dose of L‐asparaginase and 2) the protocol‐calculated dose of L‐asparaginase. The extent to which the chemotherapy dose modification varied according to obesity status was assessed using stratified Student t tests and an ordinary least‐squares regression analysis.RESULTSObese ALL patients were found to exhibit a 7% decrease in the mean relative modification of L‐asparaginase during induction chemotherapy compared with their nonobese counterparts. This finding was statistically significant (P = 0.009), even after adjustment for gender, age, ethnicity, and clinical institution.CONCLUSIONSTo the authors' knowledge, the current study is the first published report of an obesity‐associated chemotherapy dose modification in pediatric patients with ALL, the most common childhood malignancy. It will be important to examine whether these findings are consistent with those observed in future studies, and ultimately to assess the association between obesity‐related dose modifications and long‐term cancer outcomes. Cancer 2005. © 2005 American Cancer Society.
Performance analysis of high‐performance file‐transfer systems for Grid applications
Authors: Anglano Cosimo , Canonico Massimo 
Published: November 2005

AbstractData‐intensive Grid applications require the availability of tools able to transfer very large files in the shortest amount of time. Many file‐transfer tools, based on solutions aimed at overcoming the limitations imposed by the TCP protocol, have recently been developed. In this paper we experimentally compare the performance of some of these tools in various network scenarios by running experiments on PlanetLab, an open platform for the development, deployment, and access of planetary‐scale services, that comprises hundreds of hosts scattered across the globe. Our results show that solutions based on UDP and adopting rate‐based algorithms result in better performance than other alternatives in most cases, while solutions based on TCP achieve similar performance only under specific circumstances. Copyright © 2005 John Wiley & Sons, Ltd.
Reputation‐based semantic service discovery
Authors: Shaikh Ali Ali , Majithia Shalil , Rana Omer F. , Walker David W. 
Published: November 2005

AbstractAn important component of Semantic Grid services is the support for dynamic service discovery. Dynamic service discovery requires the provision of rich and flexible metadata that is not supported by current registry services such as UDDI. We present a framework to facilitate reputation‐based service selection in Semantic Grids. Our framework has two key features that distinguish it from other work in this area. First, we propose a dynamic, adaptive, and highly fault‐tolerant reputation‐aware service discovery algorithm. Second, we present a service‐oriented distributed reputation assessment algorithm. In this paper, we describe the main components of our framework and report on our experience of developing the prototype. Copyright © 2005 John Wiley & Sons, Ltd.
An approach to the quantitative evaluation of Grid services
Authors: Andreozzi Sergio , Ciancarini Paolo , Montesi Danilo , Moretti Rocco 
Published: November 2005

AbstractIn the context of the progressive incarnation of Grid systems in terms of a Service Oriented Architecture, it is essential to improve the automatic evaluation and selection of Grid services. Current mechanisms for service evaluation lack expressiveness as regards the representation of service requesters' expectations. In this paper, we present a model for the quantitative expression of service attributes, for the association of the possible values of these attributes with the requester satisfaction and for the aggregation of a set of satisfactions in an overall score by means of different aggregation logics. The proposed approach enriches the expressiveness of the mechanisms for the evaluation of Grid services. Copyright © 2005 John Wiley & Sons, Ltd.
Supporting resource reservation and allocation for unaware applications in Grid systems
Authors: Di Stefano Antonella , Fargetta Marco , Pappalardo Giuseppe , Tramontana Emiliano 
Published: November 2005

AbstractThe dynamics of resource request rates in a Grid system can be wide ranging, to the point that request peaks for a single resource can be difficult to handle and end up greatly increasing the response time. Once a request has been submitted by a client, this has to cope with the potential overload arising. However, it is impractical to cure overload once it takes place by negotiating a different service or finding an equivalent resource, since the client would then bear the delay due to negotiation and re‐submission. Instead, in order to effectively exploit Grid resources, it is crucial that applications perform reservation of resources before using them. Reservation allows a management system to consider application needs in advance and take suitable action to improve resource availability. In particular, this enables additional resources to be secured beforehand in the background when appropriate to avoid a potential overload, rather than paying the involved costs when overload arises. This paper proposes a software architecture that integrates applications with Globus services to conveniently handle resource reservation and allocation. Within the architecture, the computational reflection technology transparently connects applications with components that take care of advance reservation, as they dynamically sense the applications' resource needs. This dynamic information augments static knowledge gathered offline from static program code analysis. Copyright © 2005 John Wiley & Sons, Ltd.
A component‐based middleware framework for configurable and reconfigurable Grid computing
Authors: Coulson Geoff , Grace Paul , Blair Gordon , Cai Wei , Cooper Chris , Duce David , Mathy Laurent , Yeung Wai Kit , Porter Barry , Sagar Musbah , Li Wei 
Published: November 2005

AbstractSignificant progress has been made in the design and development of Grid middleware which, in its present form, is founded on Web services technologies. However, we argue that present‐day Grid middleware is severely limited in supporting projected next‐generation applications which will involve pervasive and heterogeneous networked infrastructures, and advanced services such as collaborative distributed visualization. In this paper we discuss a new Grid middleware framework that features (i) support for advanced network services based on the novel concept of pluggable overlay networks, (ii) an architectural framework for constructing bespoke Grid middleware platforms in terms of ‘middleware domains’ such as extensible interaction types and resource discovery. We believe that such features will become increasingly essential with the emergence of next‐generation e‐Science applications. Copyright © 2005 John Wiley & Sons, Ltd.
Absolute Configuration of C76 from Optical Rotatory Dispersion
Authors: Polavarapu Prasad L. , He Jiangtao , Crassous Jeanne , Ruud Kenneth 
Published: November 2005

AbstractThe absolute configuration of C76 has been determined as (+)589‐(fC)‐C76 , for the first time, by comparing the experimental and predicted optical rotatory dispersion (ORD) patterns. The experimental ORD pattern was derived from the experimental electronic circular dichroism (ECD) spectrum using the Kramers–Kronig (KK) transform. The theoretical ORD spectra were calculated in the resonant region using linear response theory, and also using the KK transform of the theoretical ECD spectrum, at different theoretical levels, namely BHLYP/6‐31G*, B3LYP/6‐31G*, BLYP/6‐31G*, and HF/6‐31G*. Good agreement noted between experimental and predicted spectra allows for an unambiguous determination of the absolute configuration.
Radiolysis of Confined Water: Hydrogen Production at a High Dose Rate
Authors: Le Caër Sophie , Rotureau Patricia , Brunet Francine , Charpentier Thibault , Blain Guillaume , Renault Jean Philippe , Mialocq Jean‐Claude 
Published: November 2005

AbstractThe production of molecular hydrogen in the radiolysis of dried or hydrated nanoporous controlled‐pore glasses (CPG) has been carefully studied using 10 MeV electron irraditation at high dose rate. In all cases, the H2 yield increases when the pore size decreases. Moreover, the yields measured in dried materials are two orders of magnitude smaller than those obtained in hydrated glasses. This proves that the part of the H2 coming from the surface of the material is negligible in the hydrated case. Thus, the measured yields correspond to those of nanoconfined water. Moreover, these yields are not modified by the presence of potassium bromide, which is a hydroxyl radical scavenger. This experimental observation shows that the back reaction between H2 and HO. does not take place in such confined environments. These porous materials have been characterized before and after irradiation by means of Fourier‐transform infrared (FT‐IR) spectroscopy, electron paramagnetic resonance (EPR) and nuclear magnetic resonance (NMR) techniques, which helps to understand the elementary processes taking place in this type of environment, especially the protective effect of water on the surface in the case of hydrated glasses.
Sex differences in juvenile rhesus macaque (Macaca mulatta) agonistic screams: Life history differences and effects of prenatal androgens
Authors: Tomaszycki Michelle L. , Gouzoules Harold , Wallen Kim 
Published: November 2005

AbstractThis study investigated sex differences in juvenile rhesus macaque (Macaca mulatta) vocal behavior during agonistic contexts, and the effects of prenatal androgens on these differences. A total of 59 subjects (5–8 per treatment group) received exogenous androgen (testosterone enanthate), an anti‐androgen (flutamide) or vehicle injections (DMSO) for 30 or 35 days during the second (early) or third (late) trimester of pregnancy. An additional 19 unmanipulated controls were included in the analysis. Screams by juvenile males and females between the ages of 1 and 3 years were compared to the screams of adult female exemplars using a discriminant function analysis. Juvenile females produced more adult‐female like screams than did juvenile males. Females exposed to androgen treatment late in gestation produced a more masculine pattern of screams. Flutamide treatment in males either early or late in gestation did not significantly affect scream production. Flutamide treatments in females late in gestation, however, masculinized scream production. Androgen treatments administered late in gestation hyper‐masculinized male scream production. No sex differences in the contextual usage of screams emerged. These findings suggest that both life history differences and the early hormone environment contribute to sex differences in juvenile rhesus macaque vocal production. © 2005 Wiley Periodicals, Inc.Dev Psychobiol47: 318–327, 2005.
Characterization of two new zebrafish members of the hedgehog family: Atypical expression of a zebrafish indian hedgehog gene in skeletal elements of both endochondral and dermal origins
Authors: Avaron F. , Hoffman L. , Guay D. , Akimenko M.A. 
Published: November 2005

AbstractWe have characterized two new members of the Hedgehog (Hh) family in zebrafish, ihha and dhh, encoding for orthologues of the tetrapod Indian Hedgehog (Ihh) and Desert Hedgehog (Dhh) genes, respectively. Comparison of ihha and Type X collagen (col10a1) expression during skeletal development show that ihha transcripts are located in hypertrophic chondrocytes of cartilaginous elements of the craniofacial and fin endoskeleton. Surprisingly, col10a1 expression was also detected in cells forming intramembranous bones of the head and in flat cells surrounding cartilaginous structures. The expression of col10a1 in both endochondral and intramembranous bones reflects an atypical composition of the extracellular matrix of the zebrafish craniofacial skeleton. In addition, during fin ray regeneration, both ihha and col10a1 are detected in scleroblasts, osteoblast‐like cells secreting the matrix of the dermal bone fin ray. The presence of cartilage markers suggests that the dermal fin ray possesses an intermediate phenotype between cartilage and bone. Developmental Dynamics 235:478–489, 2006. © 2005 Wiley‐Liss, Inc.
Hot hearts in the Sonoran desert: The 11th Weinstein cardiovascular development conference in Tucson
Authors: Hardy Katharine M. , Mjaatvedt Corey H. , Antin Parker B. 
Published: November 2005

AbstractThe 11th Annual Weinstein Cardiovascular Development Conference was held May 19–22, 2005 at the Westward Look Resort and Conference Center in Tucson, Arizona. The Westward Look was the site of the 6th Weinstein Meeting in 1999, and this year, 330 basic research scientists and research clinicians returned to Tucson for 3 days of meetings, Mariachis, and margaritas. The meeting was hosted by the cardiovascular research group at the University of Arizona and offered flavors of the desert southwest that included record temperatures, the Skopopelli conference logo modified from the Kokopelli of Native American mythology (Fig. 1), and liberal use of a cattle prod to encourage speaker timeliness. Developmental Dynamics 235:170–175, 2006. © 2005 Wiley‐Liss, Inc.
Expression of chondrogenic potential of mouse trunk neural crest cells by FGF2 treatment
Authors: Ido Atsushi , Ito Kazuo 
Published: November 2005

AbstractThere is a significant difference between the developmental patterns of cranial and trunk neural crest cells in the amniote. Thus, whereas cranial neural crest cells generate bone and cartilage, trunk neural crest cells do not contribute to skeletal derivatives. We examined whether mouse trunk neural crest cells can undergo chondrogenesis to analyze how the difference between the developmental patterns of cranial and trunk neural crest cells arises. Our present data demonstrate that mouse trunk neural crest cells have chondrogenic potential and that fibroblast growth factor (FGF) 2 is an inducing factor for their chondrogenesis in vitro. FGF2 altered the expression patterns of Hox9 genes and Id2, a cranial neural crest cell marker. These results suggest that environmental cues may play essential roles in generating the difference between developmental patterns of cranial and trunk neural crest cells. Developmental Dynamics 235:361–367, 2006. © 2005 Wiley‐Liss, Inc.
Expression and functional analysis of Tgif during mouse midline development
Authors: Jin Jiu‐Zhen , Gu Shi , McKinney Patrick , Ding Jixiang 
Published: November 2005

AbstractThe Tgif gene encodes a homeodomain protein that functions as a transforming growth factor beta (TGF‐β) repressor by binding to Smad2. Mutations in the TGIF gene are associated with human holoprosencephaly, a common birth defect caused by the failure of anterior ventral midline formation. However, Smad2‐mediated TGF‐β signaling in the axial mesendoderm has been demonstrated to be essential for ventral midline formation, and loss of a Smad2 antagonist should in principle promote rather than inhibit ventral midline formation. This suggests a more complex mechanism for the function of TGIF in controlling ventral midline formation. To explore the role of TGIF in ventral forebrain formation and patterning, we investigated Tgif expression and function during mouse development by in situ hybridization and gene targeting. We found that Tgif is highly expressed in the anterior neural plate, consistent with the proposed neural differentiation model in which TGF‐β suppression is required for normal neural differentiation. This result suggests a possible role for Tgif in anterior neural differentiation and patterning. However, targeted disruption of the Tgif gene during mouse development does not cause any detectable defects in development and growth. Both histological examination and gene expression analysis showed that Tgif−/− embryos have a normal ventral specification in the central nervous system, including the forebrain region. One interpretation of these results is that the loss of TGIF function is compensated by other TGF‐β antagonists such as c‐Ski and SnoN during vertebrate anterior neural development. Developmental Dynamics 235:547–553, 2006. © 2005 Wiley‐Liss, Inc.
Construction method and analysis of radiation characteristics of an ultralarge array antenna for microwave power transmission
Authors: Sugawara Akira , Takano Tadashi , Hanayama Eiji , Kami Yoshio 
Published: November 2005

AbstractWhen an ultralarge antenna for microwave power transmission is constructed, a promising realization method can be an array of subarray units made of small antennas or an array of aperture antennas. In this case, there are discontinuities of electromagnetic fields between the units or elements so that grating lobes may be generated. In this paper, a method is presented for construction of an array antenna with a diameter on the order of 1 km made of element apertures with a diameter on the order of 10 m. The radiation characteristics are discussed by an analysis. By using the element aperture gap, electric field distribution over each element aperture, and excitation intensity profile over the entire array as the parameters, variations of the radiation characteristics are studied. As a result, it is found effective as a method of suppression of the grating lobe to use the following approaches: (1) the electric field distribution of the element aperture and the aperture dimensions are appropriately selected, (2) the array antenna should have the most densely filled configuration with uniform distribution or $\cos^{2}$ distribution over each element aperture but with a Gaussian distribution over the entire array. © 2005 Wiley Periodicals, Inc. Electron Comm Jpn Pt 1, 89(3): 59–68, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecja.20245
A study of adaptive modulation technique in OFDM
Authors: Usui Tsutomu , Ishizu Fumio , Murakami Keishi 
Published: November 2005

AbstractThis paper presents the results of a study of the OFDM adaptive modulation technique. The adaptive modulation technique, which selects the modulation scheme according to the transmission conditions, is effective in improving system throughput. Then, it is important to study evaluation function under various propagation conditions. In this paper, we propose an adaptive modulation technique using the instantaneous DUR (desired signal to undesired signal ratio) per packet as the performance measure of the transmission path, in which the intersymbol interference (ISI) and intercarrier interference (ICI) power of delayed waves exceeding the guard interval are used under the assumption of convolution coding and soft‐decision Viterbi decoding. A DUR estimation method is also proposed. The effectiveness of the approach is confirmed by numerical simulation. © 2005 Wiley Periodicals, Inc. Electron Comm Jpn Pt 1, 89(3): 36–45, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecja.20254
An electrically invisible dipole loaded with a variable reactor and its applications for a reconfigurable antenna
Authors: Iigusa Kyouichi , Ohira Takashi , Komiyama Bokuji 
Published: November 2005

AbstractThis paper shows that the integral of the current flowing on a parasitic dipole can be made to vanish by supplying a reactance with an appropriate value. When a reactor is placed at the center of a half‐wave dipole with a thickness of 0.02 wavelength, the reactance value making the integral of the current vanish is about +450 Ω. The state in which the integral of the current is zero is not affected by other elements and minimizes the electrical influence on other elements. Hence, this state is considered electrically invisible. A reconfigurable (structurally variable) ESPAR antenna is proposed in which a variable reactance is placed on a parasitic dipole and the combination is adequately made electrically invisible. A method of calculation is proposed in which the admittance of the array configuration without a specific dipole element is obtained from the admittance in the presence of such an element by making it electrically invisible. Further, by this calculation method, the behavior of the admittance of an array with symmetrically placed elements is obtained. © 2005 Wiley Periodicals, Inc. Electron Comm Jpn Pt 1, 89(3): 21–35, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecja.20262