bluuebunny/crossref_metadata_2025_split huggingface dataset:
Auditory toxicity effects of long‐term cis‐dichlorodiammineplatinum II therapy in genitourinary cancer patients
Authors: Aguilar‐Markulis Nila V. , Beckley Summolu , Priore Roger , Mettlin Curtis 
Published: February 2007

AbstractTo determine the auditory toxicity effects of long‐term cis‐dichlorodiammineplatinum II therapy, pure tone hearing thresholds were measured prior to therapy and repeated before each subsequent treatment. CDDP was given by a slow intravenous drip method at a low dose of 1 mg/kg body weight, with 37.5 gm mannitol, once a week for six treatments and every 3 weeks thereafter. From a group of 173 genitourinary cancer patients treated, 50 male patients were selected who received at least 12 months of CDDP with no active conductive ear pathology, and whose audiograms obtained at baseline, 6th weeks, 26th weeks, and 52nd weeks of treatment were all available for comparison. Pure tone threshold levels deteriorated across time particularly by the 52nd week and at the higher frequencies. Threshold differences across time were statistically significant and within a linear trend. Of the 50 cases, 30% showed suspect or no ototoxicity, 26% mild, 32% moderate, 2% marked, and 4% showed severe ototoxic changes. Of the two cases who developed severe ototoxicity, one showed complete recovery. There was partial recovery in 26% and no recovery in 54%. Individual variability in susceptibility to and recovery from ototoxicity necessitates systematic audiometric monitoring throughout the therapy.
Disease‐free survival and recurrence after resection of colorectal carcinoma
Authors: Pihl Eric , Hughes Edward S. R. , McDermott Francis T. , Milne Barrie J. , Price Ann B. 
Published: February 2007

AbstractRecurrence Data From A Series Of 1, 315 Colorectal Cancer Patients Managed By One Surgeon With Potentially Curative Resection Are Presented. Complete Follow‐Up Information Was Available On 1, 287 (98%) Patients. At The Time Of The Last Recurrences, 164 And 232 Months For Rectal And Colonic Tumours Respectively, The Long‐Time Recurrence Rate Was Significantly (P = 0.001) Higher For Rectal Tumours (42%) Than For Colonic (33%). Although Local Recurrences Tended To Be More Common In Rectal Than In Colonic Tumours (18% Compared To 15%), Only Those In Contiguity With The Operative Area Were Significantly (P < 0.005) More Common In Rectal Tumours. Systemic Recurrences Were Also Significantly (P < 0.025) Commoner For Rectal Tumours. The Greater Recurrence Rates In Rectal Tumours Were Associated With Significantly (P < 0.001) Higher Incidence Of Stage C Tumours Shorter Recurrence‐Free Survival In Rectal Stage C Tumours (P = 0.001) And Higher Incidence Of Pulmonary Metastases (P < 0.001).
Factors influencing survival in bilateral breast cancer
Authors: Al‐Jurf Adel S. , Jochimsen Peter R. , Urdaneta Luis F. , Scott David H. 
Published: February 2007

AbstractOne Hundred And Four Patients With Bilateral Breast Cancers, Detected Clinically, Were Studied. Patients With Synchronous Lesions Experienced The Worst Survival. Lymph Node Metastases In The Second Mastectomy Had Obvious Adverse Effect On Survival. The Development Of Scirrhous Carcinoma In The Second Breast Did Not Alter Survival. A Maximum Of 21 Patients Might Have Been Adversely Affected By The Development Of A Second Cancer Because Of Lymph Node Metastases In The Second Breast Only. Survivorship Data Suggest The Adequacy Of Treatment Of Contralateral Breast Cancers When They Become Detectable By Clinical Means Alone.
Retroperitoneal sarcomas: A reappraisal of treatment
Authors: Storm F. Kristian , Eilber Frederick R. , Mirra Joseph , Morton Donald L. 
Published: February 2007

AbstractRetroperitoneal sarcoma, regardless of the histopathologic grade of malignancy, has a high incidence of local recurrence that is usually fatal. Surgical resection is mandatory and resectability may be improved by a midline transabdominal approach. However, even with total tumor excision, recurrence is high. A preliminary study, combining resection and preoperative adriamycin, found to be effective for established disease, suggests potentially improved prognosis. Further clinical trials employing surgery combined with adjuvant chemotherapy are warranted.
Radio frequency hyperthermia of advanced human sarcomas
Authors: Storm F. Kristian , Elliott Robert S. , Harrison William H. , Kaiser Lawrence R. , Morton Donald L. 
Published: February 2007

AbstractHyperthermia ⩾ 42°C is tumoricidal in vitro and in many animal models, although such temperatures have only recently been achieved experimentally in some human cancers. A recently developed radio frequency device that provides safe hyperthermia to any depth without surface tissue injury now permits evaluation of the effects of hyperthermia on advanced human sarcomas. Twelve patients with large sarcomas located intraabdominally [7], in the chest wall [2], proximal extremity [2], and the neck [1], were evaluated in this study. Tumor types include liposarcoma [3], rhabdomyosarcoma [2], leiomyosarcoma [2], neurofibrosarcoma [2], and one each malignant mesothelioma, undifferentiated sarcoma, and osteosarcoma. Intratumor temperatures ⩾42°C were observed in all tumors, with virtually no normal tissue injury. Selective tumor heatin ⩾45°C occurred in 9/12 (75%) and ⩾50°C in 6/12 (50%). One to five weekly treatments ⩾50°C and ten daily treatments ⩾45°C resulted in significant tumor necrosis and pain relief in some patients. Hyperthermia of advanced sarcomas is possible with little host toxicity and may be of potential therapeutic benefit.
Histiocytes in vaginal smears: As prognostic parameter in carcinoma of the uterine cervix
Authors: Gupta Saroj , Rani Abha , Gupta Y. N. , Sanyal B. , Khanna S. 
Published: February 2007

AbstractPretreatment vaginal smears of 251 patients with carcinoma of the cervix were counted for the percentage of histiocyte count in relation to benign squamous epithelial cells. No correlation was found between the percentage of histiocyte count and the age of the patient, clinical stage, cell type of squamous cell carcinoma, and clinical radiation response. Also a high histiocyte count is found to be unrelated to 5‐year survival, recurrence, metastasis, or death of these patients. The present study indicates that the histiocyte number appears to have no relationship with immediate or remote prognosis in patients with carcinoma of cervix uteri.
In vivo evaluation of cell mediated immunity against human melanoma
Authors: Akimaru Koho , Stuhlmiller Gary M. , Seigler H. F. 
Published: February 2007

AbstractEvaluation of cell mediated immunity against human melanoma target cells was performed in an in vivo model using human tumor xenografts growing in Balb/c athymic mice. Intraperitoneal inoculation of 1 × 107 human melanoma cells produced peritoneal carcinomatosis which lead to death of the animals at 23.8 ± 2.6 days (N = 12). Peripheral blood lymphocytes (PBL) from normal donors were administered to tumor bearing mice, and survival times of 22.0±2.3 days were observed (N = 8). Peripheral blood lymphocytes from four of five normal donors which had been presensitized on monolayers of melanoma tissue culture cells in vitro failed to prolong host survival times. In contrast, PBL obtained from 15 of 20 melanoma patients were found to prolong survival of the tumor bearing nude mice. Of these 15 patients, 8 were undergoing specific active immunotherapy, while 7 had not been sensitized except by the disease process. The ability of PBL obtained from patients to prolong survival of tumor bearing animals did not appear to correlate with either the stage of the disease or the patient's clinical course. The possible mechanisms for the prolonged survival and usefulness of this model are discussed.
Synovial sarcoma of abdominal wall: A case report and study of tumor fine structure
Authors: Al‐Dewachi H. S. , Sangal B. C. , Zakaria M. A. K. 
Published: February 2007

AbstractA case of synovial sarcoma in the abdominal wall of a 50‐year‐old Iraqi woman is reported. The ultrastructure of the tumor has been studied. Eight other cases of synovial sarcoma in the abdominal wall reported in the English literature up to 1978 have been reviewed.Synovial sarcomas in the abdominal wall tend to occur with a much greater frequency in women, whereas such tumors occurring in the extremities or the neck are more common in men than women.No ultrastructural studies of abdominal wall synovial sarcomas could be found in the English literature. The ultrastructural characters of this tumor are similar to those of such tumors arising in the usual sites and the neck. However, the present study has indicated that the light and dark cells reported by earlier workers are not limited solely to the epithelioid areas but are also present in the spindle cell zones.
Cancer statistics of Chinese Versus Americans
Authors: Lee Yeu‐Tsu N.(Margaret) 
Published: February 2007

AbstractCancer incidence and mortality rates of Chinese in China (Shanghai, Kwangtung), Hong Kong, and the United States (San Francisco, etc.) are presented. The rates for the U.S. white population are included for comparison. Additional mortality rates of Chinese in Japan and incidence rates of Chinese in Singapore and British Columbia are also available. Such statistics emphasize both the distinctions and the similarities in cancer problems among chinese living abroad and Chinese living in China. Some ethnic and cultural differences, as well as differences in age, site distribution, and histological subtype, of certain cancers are discussed.
Multiple biological markers and breast carcinoma: A preliminary study in the detection of recurrent disease after primary therapy
Authors: Waalkes T. Phillip , Abeloff Martin D. , Ettinger David S. , Woo Kwang B. , Gehrke Charles W. , Mrochek Jack E. 
Published: February 2007

AbstractThe use of a selected group of biological markers in breast cancer patients who are disease free but at risk of relapse after mastectomy has potential for detecting recurrent tumor before there is clinical evidence. In this preliminary study, multiple materials were serially analyzed in the body fluids of patients without overt tumor but receiving adjuvant chemotherapy because of positive axillary nodes at surgery. The total frequency of elevated levels was determined and compared for those patients who remained disease free, for those who subsequently relapsed, and for a third group of patients with proven metastases. Frequency of elevation was directly proportional to increasing disease. Although differences in the relative frequency of individual materials was observed, the same trends with increasing tumor burden were found. The results suggest that the serial measurement of biological markers has potential for indicating the presence of occult disease. A nucleus of biological markers to be considered should include carcinoembryonic antigen, urinary hydroxyprolineheatinine ratio for bone lesions, and γ‐glutamyltranspeptidase for liver involvement.
On the end results of surgical treatment of lung cancer patients depending on the type of anesthetic agent
Authors: Wagner R. I. , Frid I. A. , Evtukhin A. I. , Barchuk A. S. , Shulga N. I. 
Published: February 2007

AbstractThe end results of therapy of 346 patients with lung tumors, treated with surgery alone, are compared, depending on the type of general anesthetic agent used. Anesthesia was induced with ether in 220 patients, halothane in 103, and neuroleptanalgesia in 23 cases. All the anesthetic agents were administered in a mixture with nitrous oxide. The basic characteristics of patients, who were divided on the basis of anesthetic agent, were identical. The results show that type of anesthesia during surgical treatment for lung tumor has an effect on the end results of therapy, and the best prognosis is ensured when halothane is used. Further analysis established that the end results of surgery with halothane anesthesia are improved, when partial resection rather than radical pneumonectomy is performed, at stage 2 of malignant disease and when metastases into regional lymph nodes are absent. Such improvement may be explained by stimulation of the hypothalamo‐pituitary‐adrenal system as well as a relatively lower degree of immunosuppression and development of conditions more adverse for implantation of circulating tumor cells than in the case of ether or neuroleptanalgetic anesthesia.
Local recurrence of gastric adenocarcinomas after gastrectomy
Authors: Papachristou Dimitri N. , Fortner Joseph G. 
Published: February 2007

AbstractA study of 257 gastric cancer patients treated with gastrectomy and followed to their death showed that (a) the incidence of local recurrence in the field of gastrectomy was 25%; (b) from the three types of gastrectomy used, extended total gastrectomy resulted in the lowest incidence of recurrence, followed by subtotal and total; (c) recurrences were more common in patients with TNM stages I, II, and III tumors where extended total gastrectomy was proven superior (p < 0.05); (d) early stage tumors tended to recur in the gastric remnant and the esophagus; (e) narrow surgical margins and margins involved by disease predisposed to recurrence; (f)not every patient with histologically invaded margins developed recurrence; (g) the risk of recurrence did not decrease with time; (h) the longer the disease‐free interval the better the prognosis; (i) the more advanced the original lesion the longer the disease‐free interval; (j) of all patients with recurrence only 19% had resectable lesions on reexploration; (k) the longer the disease‐free interval the higher the resectability rate; (l) the median interval from recurrence to death was 2 months; (m) the same interval of those undergoing resection was 18 months. Patients with early‐stage tumors treated with gastrectomy should be followed closely for local recurrence and should recurrence develop they should be reexplored if there is no evidence of metastasis.
Effect of major small bowel resection on dimethylhydrazine‐induced bowel carcinogenesis
Authors: Harte P. J. , Steele G. , Rayner A. A. , Munroe A. E. , King V. P. , Wilson R. E. 
Published: February 2007

AbstractWe have investigated the effect of distal small bowel resection on chemically induced tumors of the gastrointestinal tract in Wistar/Furth (W/Fu) rats. Dimethylhydrazine (DMH) (20 mg/kg sc once weekly × 16) was commenced 3 months after rats underwent resection of the distal 30 cm of small bowel (one‐third resection) or after sham small bowel resection (controls). Fifty weeks after the start of DMH administration, tumors were found in 15 of 25 animals who underwent small bowel resection compared to 9 of 31 animals in the control group (P<0.05). After small bowel resection, 8 of 15 tumors occurred at the site of anastomosis but no anastomotic tumors were seen after sham resection. In addition, tumors were larger and more invasive after small bowel resection. These data indicate that major small bowel resection potentiates DMH induced‐intestinal carcinogenesis.
Sacral chordoma: A case study and review
Authors: Spratt John S. , Martin Anthony E. , McKeown John 
Published: February 2007

AbstractChordomas are a low grade, tenacious, but eventually lethal neoplasm for which little improvement in outcome has been reported. A current review of the literature and a case report are provided to support this position. The reported sacral chordoma did respond temporarily to chemotherapy. Its rare occurrence precludes controlled studies chordoma; therefore, any response merits reporting. The authors observed that hyperthermic chemotherapy was feasible for treating some chordomas but has not yet been reported. It was evaluated for the patient in this report.
Gastrointestinal tract complications following radiotherapy of uterine cervical cancer: Past and present
Authors: Yoonessi Mahmood , Romney Seymour , Dayem Hussein 
Published: February 2007

AbstractA retrospective analysis of the gastrointestinal tract complications in 298 patients with cervical cancer treated with radiotherapy at the State University of New York at Buffalo and Albert Einstein College of Medicine affiliated hospitals was carried out. Fifty‐two patients had pretreatment surgical staging (39 transperitoneal and 13 extraperitoneal). Twenty‐four percent had varying degrees of radiation sickness. They all responded to conservative therapy. Seven percent developed Stage I radiation proctitis. In the clinical staging group late complications consisted of: Three small bowel injuries, 4% persistent Stage I, 3% Stage III, and one patient with Stage II radiation proctitis. Among 39 patients who had transperitoneal surgical staging, two small bowel injuries, one case of gastric ulcer, and three cases of radiation proctitis were encountered. Only one of 13 patients who had extraperitoneal surgical staging developed intestino‐vesico‐vaginal fistula. A literature search was conducted, and prophylactic and therapeutic measures are discussed. The importance of careful selection of patients for radiotherapy and recognition of high risk clinical factors is reemphasized.
An unusual presentation of malignant mesothelioma: The incidental finding of tumor in the hernia sac during herniorrhaphy
Authors: Brenner Joseph , Sordillo Peter P. , Magill Gordon B. 
Published: February 2007

AbstractTwo cases of malignant mesothelioma that were found incidently at the time of hernia repair are described. In contrast to the majority of patients with peritoneal mesothelioma, both patients had a relatively prolonged survival after diagnosis, although both eventually died with widespread disease. The possible causes of this unusual presentation are discussed.
Ovarian carcinoma complicated by gastric outlet obstruction
Authors: Katz L. Brian , Frankel Albert , Cohen Carmel , Slater Gary 
Published: February 2007

AbstractTwo patients with gastric outlet obstruction secondary to ovarian carcinoma are presented. The importance of considering this complication in an obstructed patient with known ovarian carcinoma is emphasized. Treatment of this condition by gastroenterostomy can lead to significant palliation, as well as allow further treatment of the primary disease by other modalities such as chemotherapy.
Histological and epidemiological features of breast cancer in different religious groups in greater bombay
Authors: Jussawalla D. J. , Yeole B. B. , Natekar M. V. 
Published: February 2007

AbstractIn this paper an attempt has been made to study the histologic and epidemiologic features of breast cancer in women from various religious groups of Greater Bombay. The crude and age‐ adjusted incidence rates are seen to be the highest in the Parsi community followed by the Christian, Moslem, and Hindu groups. In all the religious groups, an increase in incidence of breast cancer is first seen in the third decade. This is followed by a sharp increase up to the age of 50‐54, leading to a slight drop, and then a consistent but slower rise in the older ages. The high risk of developing this cancer in Parsi women as compared with the Christian, Moslem, and Hindu experience may be due to a higher proportion of Parsi women remaining unmarried, their higher age at marriage, lower age at first pregnancy, broad spacing of pregnancies, and fewer numbers of pregnancies. The distribution according to histologic types of breast cancer in India is characterized by a high frequency of infiltrating duct carcinoma. Medullary, lobular, and squamous cell carcinoma were typical histological varieties of the older age groups, whereas ductal carcinoma was encountered mostly in premenopausal women.
Inflammatory cancer of the breast: Analysis of 114 cases
Authors: Bozzetti F. , Saccozzi R. , De Lena M. , Salvadori B. 
Published: February 2007

AbstractOne hundred and fourteen cases of inflammatory breast cancer were reviewed. Actuarial survival curves, independent of the stage and type of treatment, showed a median survival of less than 15 months. As regards the three different subgroups of 80, 14, and 20 women, N0–1–2M0, N3M0, and NxM1 respectively, the actuarial survival curves showed figures of median survival that decreased from 14 to 4 months, according to the extent of the disease. Survival rates for the subgroups of patients treated by radical mastectomy, radical mastectomy followed by radiotherapy, and radiotherapy alone were not significantly different. Neither the more sophisticated therapeutic approaches intended to modify the hormonal medium of the patients, nor the combined chemotherapy plus radiotherapy, proved to be successful. Inflammatory breast cancer should be considered a systemic disease; consequently, in spite of discouraging results, only a systemic therapeutic approach, consisting of aggressive combination chemotherapy and perhaps immunostimulation, seems worthwhile.
Lymphography in the diagnosis of non‐seminoma tumours of the testis
Authors: Wobbes Th. , Blom J. M. H. , Oldhoff J. , Schraffordt Koops H. 
Published: February 2007

AbstractIn a series of 86 lymphograms correlated to histological findings after retroperitoneal lymph node dissection or to laparotomy findings, reliability proved to be 78%. The reliability of lymphograms evaluated as positive was 88%, while that of negative lymphograms was 74%. Retro‐peritoneal lymph node metastases were detected with the aid of lymphography in 58% of the patients. It was impossible to establish a node size above which metastases could be demonstrated with certainty by lymphography.
Screening for breast cancer in a high‐risk series
Authors: Woodard Elizabeth D. , Hempelmann Louis H. , Janus Joyce , Logan Wende , Dean Peter 
Published: February 2007

AbstractA unique cohort of women at increased risk of breast cancer because of prior X‐ray treatment of acute mastitis and their selected high‐risk siblings were offered periodic breast cancer screening including physical examination of the breasts, mammography, and thermography. Twelve breast cancers were detected when fewer than four would have been expected based on age‐specific breast cancer detection rates from the National Cancer Institute/American Cancer Society Breast Cancer Demonstration Detection Projects. Mammograpy was positive in all cases but physical examination was positive in only three cases. Thermography was an unreliable indicator of disease. Given the concern over radiation‐induced risk, use of low‐dose technique and of criteria for participation that select women at high risk of breast cancer will maximize the benefit/risk ratio for mammography screening.
Squamous cell carcinoma of the thyroid gland‐transition from adenocarcinoma
Authors: Harada Tanekazu , Shimaoka Katsutaro , Yakumaru Kazuhiro , Ito Kunihiko 
Published: February 2007

AbstractEight autopsy cases of thyroid carcinoma, in which adenocarcinoma and squamous cell carcinoma coexisted, and presented. In these adenosquamous cell carcinoma, pathological findings suggest direct transition from papillary adenocarcinoma to squamous cell carcinoma, rather than transformation to squamous cell carcinoma via squamous metaplasia. We believe that squamous cell carcinoma arises from adenocarcinoma of the thyroid in most cases.