bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of Heterotopic Ossification Without Additional Long-Term NSAID Prophylaxis After Periacetabular Osteotomy and Concomitant Hip Arthroscopy
Authors: Helm J. Matthew , Stocks Omar , Crowley Brian , Aboulafia Alexis , Siahaan Jacob , Mansour Alfred A. 
Published: February 2025

Background: Periacetabular osteotomy (PAO) is an established treatment for hip dysplasia and has been increasingly combined with concomitant hip arthroscopy to address additional intra-articular hip pathology. Heterotopic ossification (HO) is a complication of arthroscopic and open hip procedures. Nonsteroidal anti-inflammatory drugs (NSAIDs) have become an established form of HO prophylaxis, but their use may delay bone healing. Purpose: To examine the incidence of HO without NSAID prophylaxis in patients after PAO with concomitant hip arthroscopy and to evaluate the impact of other variables on the development of HO in these patients. Study Design: Case series; Level of evidence, 4. Methods: Of 243 hips that underwent PAO with concomitant hip arthroscopy by a single surgeon over 11 years, 182 met the study inclusion criteria. No patients were discharged on NSAIDs for HO prophylaxis, although most took up to 6 weeks of aspirin 81 mg as part of the prophylaxis protocol for deep venous thrombosis. Radiographic images at 2 weeks, 6 weeks, and 3 months postoperatively were reviewed and graded for HO using the Brooker classification. Patient characteristics and surgical variables were recorded. The chi-square and t tests were used to determine HO incidence rates, compare groups, and identify variables associated with the presence of HO. Results: The incidence of radiographic HO was 6.6% (12/182 hips). Nine hips were Brooker grade 1, 2 were grade 2, and 1 was grade 3. Four patients experienced clinical symptoms of HO— including pain and restricted motion. Only 1 patient required a return trip to the operating room for surgical excision. Male patients were significantly more likely to develop HO than female patients ( P = .01). No other demographic or surgical factor influenced the development of HO. There were no cases of nonunion. Conclusion: There was a low incidence of HO and symptomatic HO in patients who underwent PAO with concomitant hip arthroscopy without using NSAIDs for HO prophylaxis. HO was significantly more likely to develop in male patients. Given the potential risk of NSAID use on bony union, the low incidence found in this study may obviate the need for postoperative HO prophylaxis.
Management of Isolated Partial ACL Tears: A Survey of International ACL Surgeons
Authors: Frey Christopher S. , Pierre Kinsley J. , Pham Nicole S. , Abrams Geoffrey D. , Sherman Seth L. , Spalding Tim , Safran Marc R. 
Published: February 2025

Background: Partial anterior cruciate ligament (ACL) tears, particularly injuries detected with magnetic resonance imaging (MRI) but stable on ligamentous examination, appear to be recognized more frequently; however, there remains no consensus management for this complex pathology. Purpose: To present the results of a survey of a group of international ACL experts on the management of partial ACL injuries. Study Design: Survey study; Level of evidence, 5. Methods: The ACL Study Group is an international group of orthopaedic surgeons with a special interest in the ACL. There are 169 members overall, with 135 clinically active surgeons. A branching logic survey was developed and circulated to members of the ACL Study Group via electronic mail. Categories included member demographics as well as recommended management strategies of partial ACL injuries, including recommendations on return to play. Results: Of the 135 clinically active surgeon members, 113 responded to the survey (84%). Nonoperative management of partial ACL injuries was selected by 92% of respondents. Of those who managed nonoperatively, 75% indicated they would not restrict weightbearing and 59% would not recommend a knee brace. When those who managed the patient nonoperatively determined criteria for return to sports (RTS), 33% would use differential knee laxity, 87% would assess functional testing, 26% would utilize imaging, and 40% selected time from injury. When using time as a guide for RTS, 13% chose RTS between 7 and 11 weeks postinjury, 56% selected no sport before 3 months, and 22% favored waiting 4 to 6 months before allowing an athlete with a partial ACL injury to RTS. With regard to function as a tool to determine RTS, painless Lachman, strength, swelling, and functional performance tests were all chosen by a majority of respondents. Conclusion: This study presented the results of a survey on partial ACL injury management administered to ACL Study Group active surgical members. The majority favored nonoperative management for partial ACL injuries (stable ligament examination but MRI changes in the ligament). Nonoperative treatment and RTS protocols varied and must be customized to the patient.
Combined Meniscal Saucerization and Repair Versus Subtotal Meniscectomy for Symptomatic Discoid Lateral Meniscal Tears in Children and Adolescents
Authors: Shimmyo Airi , Onishi Shintaro , Kanto Ryo , Nakayama Hiroshi , Yoshiya Shinichi , Tachibana Toshiya , Iseki Tomoya 
Published: February 2025

Background: Meniscal saucerization combined with repair of a symptomatic discoid lateral meniscus (DLM) has been expanding. However, the significance of meniscal saucerization with repair involving complex or degenerative tears remains uncertain. Purpose/Hypothesis: The purpose of this study was to assess the radiological and clinical outcomes of saucerization with repair performed for symptomatic DLM tears in children and adolescents in comparison with a historical control cohort undergoing subtotal meniscectomy. It was hypothesized that saucerization with repair would lead to superior outcomes compared with subtotal meniscectomy. Study Design: Cohort study; Level of evidence, 3. Methods: This study group consisted of 27 knees in 21 patients who underwent saucerization with repair (SR group) between 2011 and 2018, while the historical control group included 22 knees in 20 patients who underwent subtotal meniscectomy (SM group) between 2005 and 2011. Patient age at the time of surgery ranged from 4 to 18 years (mean, 12.1 years). Clinical outcomes were assessed using the Lysholm score. The Tapper and Hoover classification based on Rosenberg view radiographs was adopted, and lateral joint space width was measured as a parameter for cartilage/meniscus preservation. Clinical and radiological results were evaluated preoperatively, 2 years postsurgery, and until the final follow-up. Results: The mean follow-up period was 50.6 ± 17.0 months in the SR group and 62.3 ± 41.0 months in the SM group. Lysholm scores significantly improved postoperatively in both groups ( P < .001). As for radiological evaluation, a progression in the Tapper and Hoover classification grade and a significant increase in lateral joint space width ( P < .001) between the right and left sides were observed in both groups at 2 years postoperatively, with no significant differences between groups. Complications included postoperative retearing in 5 cases (18.5%) from the SR group, and osteochondritis dissecans (OCD) developed after surgery in 1 knee (4%) in the SR group and 6 knees in the SM group (27%), with a significantly higher incidence in the SM group ( P = .036). Conclusion: Both groups showed progressive postoperative radiographic degeneration, and clinical outcomes also improved in both groups. Based on the incidence of OCD development, saucerization with repair for complex DLM tears showed advantages over subtotal meniscectomy.
Reasons for and Complications Following Revision Tibial Tubercle Osteotomy
Authors: Varady Nathan H. , Uppstrom Tyler J. , Shah Aakash , Rizy Morgan , Neijna Ava G. , Gomoll Andreas H. , Strickland Sabrina M. 
Published: February 2025

Background: While tibial tubercle osteotomy (TTO) is a highly effective treatment for patellofemoral malalignment, some patients may have recurrent symptoms after surgery. To date, there are little data on revision TTO (rTTO) and its outcomes. Purpose: To evaluate the (1) reasons for and (2) complications following rTTO. Study Design: Case series; Level of evidence, 4. Methods: This was a retrospective review of patients who underwent rTTO from a single high-volume patellofemoral surgeon between 2016 and 2023. All included patients had a minimum of 3 months of follow-up data. Demographic characteristics, indications for primary and revision surgery, operative characteristics, concomitant procedures, range of motion at 6 and 12 weeks postoperatively, radiographic data, and complications were collected. Results: There were 16 knees (14 patients) that underwent rTTO, including 10 (63%) for persistent malignment (all of which had chondral damage requiring concomitant intervention) and 6 (38%) for fracture/nonunion. The knees undergoing rTTO for malalignment were 90% female, compared with 33% female for fracture/nonunion ( P = .04). For persistent malalignment rTTO, the only complication (10% [1/10]) was arthrofibrosis (0°-65° at 6 weeks postoperatively), requiring arthroscopic lysis of adhesions (0°-140° at 12 weeks postoperatively). Within the follow-up available (median, 2.2 years; range, 9 months-5.3 years), there were no cases of new or recurrent patellar instability after rTTO. Similarly, at a median follow-up of 1.2 years (range, 4 months–3.0 years), all 6 knees that underwent rTTO for fracture/nonunion achieved union, with delayed union requiring percutaneous bone marrow grafting at 4 months postoperatively being the only complication in this cohort. Conclusion: Patients who underwent rTTO demonstrated low complication rates and high union rates in this study. There was a high prevalence of chondral damage requiring concomitant intervention among patients undergoing rTTO for persistent malalignment. While rTTO is a relatively rare procedure, these data suggest that it can be a safe and effective option for patients with recurrent symptoms or fracture/nonunion after primary TTO.
“‘We don’t want them to have to live out their lives in the hospital”: mixed-methods study exploring palliative care needs amongst refugees‘
Authors: Gupta Priya , Gill Ashlinder , Panza Michael , Wahoush Olive , Saeed Humaira , Chagani Jehan Ara , Owoo Christiana , Klinger Christopher 
Published: February 2025

Background: The increasing life expectancy and resultant chronic medical comorbidities have resulted in more people requiring palliative care. Unfortunately, palliative care is restricted to marginalized populations, including refugees. In Canada, refugees are only eligible for federal health insurance, which provides basic medical and social coverage until they can obtain provincial health insurance. Objectives: This study explored limitations in providing palliative care to refugees who had either federal or provincial health insurance in two care settings in Ontario, Canada. Design: An explanatory sequential mixed-methods approach guided the review of local administrative data and interview data to understand palliative care delivery for refugees. Methods: Local administrative data from a community health centre and an acute care hospital providing a palliative care approach were collected to review healthcare utilization for refugees with palliative care needs. Interviews from two focus groups with fourteen healthcare providers shared their care experiences in coordinating palliative care for refugees with either federal or provincial health insurance. Results: Refugee patients with palliative care needs appeared to be accessing acute care services frequently to meet their needs over a 5-year period. Due to a lack of citizenship or permanent residency status, many refugees have access to only federal health insurance. Compared to those with routine provincial coverage, federally insured patients were admitted more frequently. Furthermore, healthcare provider experiences revealed that refugees with only federal insurance coverage had significant barriers to accessing community palliative care support, leading to increased reliance on acute care for quality palliative care. Conclusion: This study highlights significant gaps in palliative care access for refugees, especially those with federal health insurance. Equitable access is essential in ensuring that patient-centred, quality palliative care is available to all.
Early Saphenous Venous Graft Pseudoaneurysm, a Rare Cause of Acute Coronary Syndrome: Too Early or Too Late—A Management Dilemma
Authors: Jariwala Pankaj , Atmakur Gautam , Kulkarni Gururaj Pramod , Jariwala Anusha 
Published: February 2025

A saphenous vein graft (SVG) is a bypass conduit that is frequently employed in surgical revascularization operations. One of the primary issues with SVGs is that they can encounter blockage rates of up to 25% within the first year. Saphenous venous graft aneurysms (SVGAs) are extremely uncommon, yet they can develop at any time. While early SVG degeneration may result in SVGAs, the classic indications of myocardial ischemia are often associated with late SVG degeneration. Other methods of imaging, including coronary computed tomography and graft angiography, can detect SVGA that would otherwise go undetected. This issue may cause mortality to be underestimated, resulting in fatalities that go unnoticed and uninvestigated. The major goal of this case report was to offer a detailed account of an early SVGA episode in a patient who had a documented non-ST-segment myocardial infarction and significant myocardial ischemia, as confirmed by coronary artery angiotomography.
Sphingolipid metabolites involved in the pathogenesis of atherosclerosis: perspectives on sphingolipids in atherosclerosis
Authors: Zhao Fufangyu , Shao Mingyan , Li Mingrui , Li Tianxing , Zheng Yanfei , Sun Wenlong , Ni Cheng , Li Lingru 
Published: February 2025

Abstract
Atherosclerosis, with its complex pathogenesis, is a leading underlying cause of many cardiovascular diseases, which are increasingly prevalent in the population. Sphingolipids play an important role in the development of atherosclerosis. Key metabolites and enzymes in sphingolipid metabolism influence the pathogenesis of atherosclerosis in a variety of ways, including inflammatory responses and oxidative stress. Thus, an investigation of sphingolipid metabolism-related metabolites and key enzymes may provide novel insights and treatment targets for atherosclerosis. This review discusses various mechanisms and research progress on the relationship between various sphingolipid metabolites, related enzymes, and atherosclerosis. Finally, we look into the future research direction of phytosphingolipids.

Graphical Abstract
A novel roseosiphovirus infecting dinoroseobacter shibae DFL12T represents a new genus
Authors: Wei Nana , Lu Longfei , Li Yingying , Ding Bo , Cai Lanlan , Yang Yunlan 
Published: February 2025

Abstract
Bacteria belonging to the Roseobacter clade are key players in marine ecosystems, contributing significantly to carbon and sulfur cycles. Marine viruses, particularly those targeting Roseobacter, play crucial roles in regulating microbial communities and biogeochemical processes. Despite their importance, phages infecting organisms of the Roseobacter clade remain poorly understood. In this study, a novel roseophage, vB_DshS-R26L (R26L), infecting Dinoroseobacter shibae DFL12T, was isolated and characterized in terms of physiological and genomic properties. R26L has siphovirus morphology with an elongated head and a long, non-flexible tail. The phage has a narrow host range and demonstrates a long infection cycle with a latent period of 3.5 h and a burst size of 22 plaque-forming units (PFU cell− 1). R26L possesses a circular, double-stranded DNA genome of 79,534 bp with a G + C content of 62.6%, encoding a total of 116 open reading frames. Notably, seven auxiliary metabolic genes (AMGs), including those related to phosphate metabolism and queuosine biosynthesis, were identified. Phylogenetic and taxonomic analyses revealed that R26L represents a new genus, with its highest intergenomic similarities being 54.7% to another roseophage (R5C). By elucidating the unique characteristics of R26L, this study highlights the complexity of phage infections and the genomic diversity of roseophages, offering valuable insights into the ecological significance of Roseobacter–phage interactions in marine environments.
Autophagy is involved in the toxicity of the biocontrol agent GC16 against Tetranychus pueraricola (Acari: Tetranychidae) based on transcriptomic and proteomic analyses
Authors: He Yanyan , Du Guangzu , Wang Guang , Guan Huiming , Zhu Shusheng , Chen Bin , He Xiahong , Zhu Youyong 
Published: February 2025

Abstract

Background
GC16 is a novel pesticide with acaricidal properties against the spider mite Tetranychus pueraricola (Ehara & Gotoh). Its physiological mechanisms have been described previously, but its molecular mechanisms of action remain unclear. Thus, we aimed to explore the acaricidal mechanisms of GC16 through transcriptomic and proteomic analyses. The results were verified using transmission electron microscopy (TEM), immunofluorescence assay, and western blotting.

Results
Transcriptomic and proteomic analyses revealed 2717 differentially expressed genes (DEGs) and 374 differentially expressed proteins (DEPs) between the GC16-treated and control mites. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis indicated that the DEGs and DEPs were enriched in the autophagy pathway. TEM showed that the number of autophagosomes and autolysosomes was higher in the GC16-treated mites than in the control mites. Immunofluorescence assay and western blot results consistently indicated that GC16 treatment significantly enhanced the relative expression of the autophagy protein LC3 in insect Sf9 cells. The intracellular calcium concentration in the GC16-treated Sf9 cells was 2.30 times higher than that in the control cells, suggesting that GC16 disrupted calcium homeostasis and potentially acted as a calcium-driven nerve agent.

Conclusions
Autophagy is involved in the toxicity of GC16 against T. pueraricola and may be activated by elevated Ca2+ levels. This study reveals the molecular insecticidal mechanisms of GC16 and provides rationale for the field application of GC16 to control pest mites.
Isolated oculomotor nerve palsy due to mesencephalic infarction diagnosed by ZOOM DWI
Authors: Wang Shangpei , Cai Yajie , Wu Xiaosan , Yan Sunhong , Wang Longsheng 
Published: February 2025

Abstract

Background
Oculomotor nerve palsy is a common neurological presentation in daily practice.

Case presentation
A 55-year-old man presented with a 3-h history of diplopia and drooping of his bilateral especially left eyelids. Examination revealed an isolated oculomotor nerve palsy consisting of left medial rectus, inferior oblique, superior rectus, inferior rectus with intact pupillary reflexes and bilateral especially left superior palpebral levator. Conventional diffusion weighted imaging (DWI) of the brain showed a suspicious restriction in the left midbrain periaqueductal region. If the clinical symptomatology indicates a lesion in the midbrain, of which a high signal intensity was encountered from neurologically healthy older adults, the limited spatial resolution of conventional axial DWI is an enormous disadvantage. Zonally magnified oblique multislice (ZOOM) DWI correlated with apparent diffusion coefficient map providing higher accuracy for accurate diagnosis can identify signal alterations of mesencephalic interpeduncle area.

Conclusions
This is a rare presentation of isolated oculomotor nerve palsy due to pure mesencephalic infarction especially verified by ZOOM DWI.
Incidence of type 2 diabetes and metabolic syndrome by Occupation – 10-Year follow-up of the Gutenberg Health Study
Authors: Bauer Juliane , Hegewald Janice , Rossnagel Karin , Jankowiak Sylvia , Prigge Michaela , Chalabi Julian , Nübling Matthias , Freiberg Alice , Riechmann-Wolf Merle , Dietz Pavel , Wild Philipp S. , Koeck Thomas , Beutel Manfred E. , Pfeiffer Norbert , Lackner Karl J. , Münzel Thomas , Strauch Konstantin , Lurz Philipp , Tüscher Oliver , Weinmann-Menke Julia , Konstantinides Stavros , Seidler Andreas 
Published: February 2025

Abstract

Background
In view of demographic change, rising retirement age, and a growing shortage of skilled workers, it is increasingly important to prevent widespread diseases such as type 2 diabetes or its risk factor metabolic syndrome. Since the workplace is an important setting for preventive measures and little is known about incident cases in the working population, the aim of this study was to identify vulnerable occupational groups for whom these interventions are particularly appropriate. Therefore, we investigated the 10-year incidence of type 2 diabetes and metabolic syndrome across occupational groups in Germany.

Methods
Employees of the population-based Gutenberg-Health-Study (GHS) were examined at baseline (2007–2012) and 10 years later. We calculated age- and sex-standardised incidence rates and standardised incidence ratios (SIR) with a 95% confidence interval (CI) for occupations, job complexity levels, and supervisory and managerial positions. 5954 persons at risk for type 2 diabetes and 5103 at risk for metabolic syndrome were observed.

Results
Between baseline and follow-up, 388 cases of type 2 diabetes and 1104 cases of metabolic syndrome occurred, and standardised incidences were 6.9% and 22.6%, respectively. The highest incidence of type 2 diabetes was observed in the occupational group “food production and processing” (20.7%) with a threefold increased incidence (SIR = 3.0, 95% CI 1.8–4.7) compared to the total working population of the GHS. Employees in “metal production, processing and construction” had the highest incidence of metabolic syndrome and a two times higher SIR (48.5%; SIR = 2.1, 95% CI 1.4–2.9). There was also a high incidence of both type 2 diabetes and metabolic syndrome in “cleaners” (16.5% and 34.8%) and “drivers and mobile plant operators” (14.8% and 41.2%). An increased incidence of type 2 diabetes and metabolic syndrome was observed with decreasing job complexity levels.

Conclusions
This study shows wide differences in the incidence of type 2 diabetes and metabolic syndrome between occupational groups and highlights the vulnerability of certain occupations. As the workplace is an important platform for interventions, the findings of this study could guide the development of more nuanced and effective workplace health initiatives to promote a healthier workforce for the future.