bluuebunny/crossref_metadata_2025_split huggingface dataset:
Commercial value of panic buying and its marketing implications
Authors: Lim Weng Marc , Kalantari Hassan Daronkola , Perera Chamila Roshani 
Published: April 2024

AbstractIn the wake of the significant impact of the COVID‐19 pandemic on industries and societies worldwide, the world has transitioned into a new normal marked by increased susceptibility to disruptive, volatile, uncertain, complex, and ambiguous (DVUCA) events. In this new normal, panic buying has proliferated into a pervasive global consumer behavior, rendering far‐reaching implications on economies and societies worldwide and thus necessitating thorough investigation. Existing literature on panic buying is constrained by two noteworthy limitations: firstly, the scarcity of studies that delineate the commercial impact of panic buying, and secondly, the dearth of longitudinal data in panic buying research. Addressing these gaps, this study employs longitudinal multi‐sourced monthly and seasonally adjusted secondary data comprising retail revenue of supermarkets and grocery stores and related COVID‐19 indicators in Australia to establish a case of panic buying and examine its commercial impact. Using 10 generalized least squares and two‐stage least squares regressions, we observe a positive, statistically significant relationship between the intensity of external crises and retail revenue, even when accounting for control and instrumental variables. Specifically, the increasing number of COVID‐19 new cases was found to produce a positive and significant effect on supermarket and grocery store revenue, with each new case contributing AU $0.02 million. Therefore, the present study contributes alternative evidence from the field that not only reaffirms the effect of externalities such as COVID‐19 in stimulating panic buying among consumers, but also highlights, for the first time, the commercial value of panic buying. The marketing implications of these findings in the new normal are also discussed.
A multicenter prospective observational study appraising the effectiveness of the Supera stent after subintimal recanalization of femoro‐popliteal artery occlusion: The SUPERSUB II study
Authors: Palena Luis Mariano , Isernia Giacomo , Parlani Gianbattista , Veroux Pierfrancesco , Ficarelli Ilaria , Frascheri Arian , Pischedda Aldo , Patrone Lorenzo , Dionisi Carlo Patrizio , Cianni Roberto , Airoldi Flavio , Landino Pietro , Kleiban Andrès , Filauri Pietro , Passalacqua Giovanni , Antignani Pier Luigi , De Rose Enrico , Valls Albert , Biondi‐Zoccai Giuseppe , Manzi Marco 
Published: April 2024

AbstractBackgroundComplex femoropopliteal artery disease represents a challenge. The Supera stent holds the promise of improving the results of endovascular therapy for complex femoropopliteal disease.AimsWe aimed at appraising the early and long‐term effectiveness of the Supera stent after successful subintimal angioplasty (SuperSUB strategy) for complex femoropopliteal lesions.MethodsWe conducted a multicenter, prospective, single‐arm observational study including consecutive patients at participating centers in whom Supera was implanted after successful subintimal angioplasty for complex femoropopliteal lesions.ResultsA total of 92 patients were included Femoropopliteal arteries were the most common target, and lesion length was 261 ± 102 mm. Most procedures were technically demanding, with antegrade femoral access in 35 (38%) and retrograde distal access in 55 (60%). Supera stent length was 281 ± 111 mm, with 4, 5, and 6 mm devices being most commonly used: 32 (35%), 35 (38%), and 23 (25%), respectively. Technical success was achieved in 100% of subjects, as was clinical success (per subject), whereas procedural success (per subject) was obtained in 98%. At 24 months, freedom from clinically driven target lesion revascularization was 93%, whereas primary patency was 87%. When compared with a similar historical cohort, Supera stent use appeared to be associated with a reduction in resources.ConclusionUse of Supera stent after successful subintimal recanalization of complex lower limb arterial lesions yields favorable procedural results, which are maintained over follow‐up, and are associated also with a favorable resource use profile.
A case report on multisystem inflammatory syndrome in children (MIS‐C) associated with COVID‐19 infection
Authors: Bhandari Roshan , Paudyal Richa , Paudyal Abhigya , Beniwal Shreya Singh 
Published: April 2024

Key Clinical MessageEarly recognition and treatment of Multisystem Inflammatory Syndrome in Children (MIS‐C) within the context of COVID‐19 infection is crucial for improved outcomes. Prompt intervention with IVIG and steroids leads to significant improvement in a severe case of MIS‐C. Clinicians should be vigilant for MIS‐C symptoms and initiate timely management.AbstractWe report a case involving a fourteen‐year‐old male with COVID‐19 infection who developed multisystem inflammatory disease. A previously healthy child presented with a history of 10 days of fever and cough, along with diarrhea, and vomiting for 3 days. His COVID‐19 infection was confirmed through Polymerase Chain Reaction (PCR), and the laboratory values were remarkable for high levels of C‐reactive protein, D‐dimers, B‐type natriuretic peptide (BNP), and troponin I. He developed circulatory shock on the second day of the presentation and needed inotropic support. Steroids and intravenous immunoglobulin (IVIG) were started in light of Multisystem Inflammatory Syndrome in Children (MIS‐C), which improved his condition. Thus, during the management of COVID‐19 infection, early detection and a careful clinical characterization for MIS‐C are essential.
Chemoenzymatic Synthesis of Tri‐antennary N‐Glycans Terminating in Sialyl‐Lewisx Reveals the Importance of Glycan Complexity for Influenza A Virus Receptor Binding
Authors: Li Tiehai , Spruit Cindy M. , Wei Na , Liu Lin , Wolfert Margreet A. , de Vries Robert P. , Boons Geert‐Jan 
Published: April 2024

AbstractSialyl‐Lewisx (SLex) is involved in immune regulation, human fertilization, cancer, and bacterial and viral diseases. The influence of the complex glycan structures, which can present SLex epitopes, on binding is largely unknown. We report here a chemoenzymatic strategy for the preparation of a panel of twenty‐two isomeric asymmetrical tri‐antennary N‐glycans presenting SLex‐Lex epitopes on either the MGAT4 or MGAT5 arm that include putative high‐affinity ligands for E‐selectin. The N‐glycans were prepared starting from a sialoglycopeptide isolated from egg yolk powder and took advantage of inherent substrate preferences of glycosyltransferases and the use of 5′‐diphospho‐N‐trifluoracetylglucosamine (UDP‐GlcNHTFA) that can be transferred by branching N‐acetylglucosaminyltransferases to give, after base treatment, GlcNH2‐containing glycans that temporarily disable an antenna from enzymatic modification. Glycan microarray binding studies showed that E‐selectin bound equally well to linear glycans and tri‐antennary N‐glycans presenting SLex‐Lex. On the other hand, it was found that hemagglutinins (HA) of H5 influenza A viruses (IAV) preferentially bound the tri‐antennary N‐glycans. Furthermore, several H5 HAs preferentially bound to N‐glycan presenting SLex on the MGAT4 arm. SLex is displayed in the respiratory tract of several avian species, demonstrating the relevance of investigating the binding of, among others IAVs, to complex N‐glycans presenting SLex.
A review on applications of fine particles integrated with fluidization technologies
Authors: Song Yue , Yuan Yue , Zhu Jesse 
Published: April 2024

AbstractFine particles possess remarkable characteristics including extensive surface‐to‐weight ratios and diverse morphologies. Consequently, through the use of fluidization techniques, they have become favoured in various industrial processes, especially with continuous production. This review paper offers a comprehensive exploration of the integration of fine particle applications with fluidization technologies, with a specific focus on the Geldart Group C particles sized <25–40 μm. Although there are challenges with processing fine particles such as the strong cohesion in fluidized beds, recent progress, including the nanoparticle modulation method, has demonstrated potential solutions. These advancements render these cohesive particles applicable to industrial applications in different fields, including gas‐phase catalytic reactions, gas–solid fluidized bed coal beneficiation, ultrafine powder coating (UPC), pharmaceuticals, environmental sustainability, energy storage, and food processing. However, further research is needed to obtain a better understanding of fine particle fluidization in industrial settings in order to achieve larger‐scale implementation. In summary, this review provides a comprehensive overview of fine particle utilization integrated with fluidization technologies, demonstrating the potential in large‐scale industrial processes, and enabling significant advancements in practical applications.
Annulation Cascades of Cyclosulfonium Salts and Alkenes towards Sulfur‐Containing N‐Heterocycles by Visible Light/Copper Catalysis
Authors: Ma Jie , Li Xufeng , Chen Yuqing , Shi Yongjia , Song Xiuyan , Lv Jian , Yang Daoshan 
Published: April 2024

Comprehensive SummaryAlthough, great achievements have been made in the synthesis of heterocycles using radical addition/cyclization strategy, developing versatile alkyl radical precursors, especially the non‐stabilized long chain alkyl radicals for this strategy still remains a huge challenge. Herein, we report an efficient annulation cascade reaction between cyclosulfonium salts and alkenes for the synthesis of sulfur‐containing N‐heterocycles by visible light/copper catalysis under mild conditions. The C—S bond cleavage/radical cascade reaction delivers a variety of corresponding N‐heterocycles containing aryl alkyl thioether motifs with good functional group tolerance. Significantly, the current system could be used for the late‐stage functionalization of complex bioactive molecules.
Effect of Thermo‐ and pH‐Sensitive Block Copolymer Structure and Composition on the Synthesis and Stabilization of Gold Nanoparticles
Authors: Yin Fang , Wan Yuezhan , Ciuculescu‐Pradines Diana , Lauth‐de Viguerie Nancy , Marty Jean‐Daniel 
Published: April 2024

AbstractHomopolymers of poly[N‐(2‐(diethylamino)ethyl) acrylamide] exhibit the ability to adsorb onto the surface of preformed or growing gold nanoparticles. The resulting hybrid materials possess a pH and thermo‐sensitive nature. Consequently, their optical properties can be modulated by manipulating either the temperature or the pH. Moreover, introducing monomers based on poly(N‐isopropyl acrylamide) into block or random statistical polymers enables further modulation of the thermosensitive properties. These copolymers, employed for the in‐situ synthesis and/or stabilization of gold nanoparticles, lead to hybrid materials whose properties and/or particle size depend on the polymer composition and microstructure: statistical polymers emerge as superior stabilizing agents compared to their block counterparts at a constant composition.
Reciprocal crosstalk between Th17 and mesothelial cells promotes metastasis‐associated adhesion of ovarian cancer cells
Authors: Neuhaus Felix , Lieber Sonja , Shinkevich Veronika , Steitz Anna Mary , Raifer Hartmann , Roth Kathrin , Finkernagel Florian , Worzfeld Thomas , Burchert Andreas , Keber Corinna , Nist Andrea , Stiewe Thorsten , Reinartz Silke , Beutgen Vanessa M. , Graumann Johannes , Pauck Kim , Garn Holger , Gaida Matthias , Müller Rolf , Huber Magdalena 
Published: April 2024

AbstractBackgroundIL‐17A and TNF synergistically promote inflammation and tumorigenesis. Their interplay and impact on ovarian carcinoma (OC) progression are, however, poorly understood. We addressed this question focusing on mesothelial cells, whose interaction with tumor cells is known to play a pivotal role in transcoelomic metastasis formation.MethodsFlow‐cytometry and immunohistochemistry experiments were employed to identify cellular sources of IL‐17A and TNF. Changes in transcriptomes and secretomes were determined by bulk and single cell RNA sequencing as well as affinity proteomics. Functional consequences were investigated by microscopic analyses and tumor cell adhesion assays. Potential clinical implications were assessed by immunohistochemistry and survival analyses.ResultsWe identified Th17 cells as the main population of IL‐17A‐ and TNF producers in ascites and detected their accumulation in early omental metastases. Both IL‐17A and its receptor subunit IL‐17RC were associated with short survival of OC patients, pointing to a role in clinical progression. IL‐17A and TNF synergistically induced the reprogramming of mesothelial cells towards a pro‐inflammatory mesenchymal phenotype, concomitantly with a loss of tight junctions and an impairment of mesothelial monolayer integrity, thereby promoting cancer cell adhesion. IL‐17A and TNF synergistically induced the Th17‐promoting cytokines IL‐6 and IL‐1β as well as the Th17‐attracting chemokine CCL20 in mesothelial cells, indicating a reciprocal crosstalk that potentiates the tumor‐promoting role of Th17 cells in OC.ConclusionsOur findings reveal a novel function for Th17 cells in the OC microenvironment, which entails the IL‐17A/TNF‐mediated induction of mesothelial‐mesenchymal transition, disruption of mesothelial layer integrity and consequently promotion of OC cell adhesion. These effects are potentiated by a positive feedback loop between mesothelial and Th17 cells. Together with the observed clinical associations and accumulation of Th17 cells in omental micrometastases, our observations point to a potential role in early metastases formation and thus to new therapeutic options.
Circulating immune cell landscape and T‐cell abnormalities in patients with moyamoya disease
Authors: Ge Peicong , Tao Chuming , Wang Wenjing , He Qiheng , Liu Chenglong , Zheng Zhiyao , Mou Siqi , Zhang Bojian , Liu Xingju , Zhang Qian , Wang Rong , Li Hao , Zhang Dong , Zhao Jizong 
Published: April 2024

AbstractBackgroundMoyamoya disease (MMD) stands as a prominent cause of stroke among children and adolescents in East Asian populations. Although a growing body of evidence suggests that dysregulated inflammation and autoimmune responses might contribute to the development of MMD, a comprehensive and detailed understanding of the alterations in circulating immune cells associated with MMD remains elusive.MethodsIn this study, we employed a combination of single‐cell RNA sequencing (scRNA‐seq), mass cytometry and RNA‐sequencing techniques to compare immune cell profiles in peripheral blood samples obtained from patients with MMD and age‐matched healthy controls.ResultsOur investigation unveiled immune dysfunction in MMD patients, primarily characterized by perturbations in T‐cell (TC) subpopulations, including a reduction in effector TCs and an increase in regulatory TCs (Tregs). Additionally, we observed diminished natural killer cells and dendritic cells alongside heightened B cells and monocytes in MMD patients. Notably, within the MMD group, there was an augmented proportion of fragile Tregs, whereas the stable Treg fraction decreased. MMD was also linked to heightened immune activation, as evidenced by elevated expression levels of HLA‐DR and p‐STAT3.ConclusionsOur findings offer a comprehensive view of the circulating immune cell landscape in MMD patients. Immune dysregulation in patients with MMD was characterized by alterations in T‐cell populations, including a decrease in effector T‐cells and an increase in regulatory T‐cells (Tregs), suggest a potential role for disrupted circulating immunity in the aetiology of MMD.
Compact ultrawideband MIMO slot antenna with high isolation
Authors: Chen Gui Run , Ye Liang Hua , Jiang Huan , Tian Xinxin , Hu Zhenxin , Li Jian‐Feng 
Published: April 2024

SummaryAn ultrawideband multiple‐input‐multiple‐output (MIMO) slot antenna with a small size and high isolation is introduced. Two multi‐stepped microstrip lines are used to feed the MIMO antenna and the ground plane is designed in a defective structure for achieving good impedance matching in an ultrawide frequency range. A 3T‐shaped strip is utilized to diminish the coupling between the two microstrip feed lines for isolation improvement over the operating band. Two open‐end rectangular slots are attached in the ground plane of the MIMO antenna to generate anti‐phase current for further enhancing the isolation. By using this novel method, a compact ultrawideband MIMO slot antenna is designed and measured. It obtains an ultrawide bandwidth of 162.0%, ranging from 0.63 to 6 GHz, and excellent isolation of beyond 20 dB. Additionally, our MIMO antenna achieves a very low envelope correlation coefficient (ECC) of below 0.005, indicating its good diversity performance.
Postfire reproduction of a serotinous conifer, the giant sequoia, in the Nelder Grove, California
Authors: Hanson Chad T. , Chi Tonja Y. , Baker Bryant C. , Khosla Maya , Dorsey Michael K. 
Published: April 2024

AbstractThe giant sequoia, a serotinous conifer naturally occurring in mixed‐conifer forests of the southern and central Sierra Nevada, California, USA, is the world's largest tree species. Giant sequoia reproduction has been severely lacking over the past century, due to fire exclusion, creating a significant conservation threat. Previous research on postfire sequoia reproduction in high‐severity fire areas, relative to low‐ and moderate‐severity areas, is limited. At 6 years postfire, we investigated giant sequoia reproduction in a high‐severity fire area, and nearby low‐/mixed‐severity fire areas, in the Nelder Grove, which burned in 2017 in the Railroad fire. Postfire giant sequoia reproduction was positively correlated with fire severity in terms of density, height (growth), and proportion (relative to other conifer species), and sequoia seedling/sapling density was positively correlated with percent shrub cover. There was no correlation between distance to live sequoia seed source and density of sequoia reproduction. More research is needed in other mixed‐severity fire areas, with larger high‐severity fire patches, to determine whether a similar postfire response occurs elsewhere.
Environmental heterogeneity at two spatial scales affects litter diversity–decomposition relationships
Authors: Ospina‐Bautista Fabiola , Srivastava Diane S. , Realpe Emilio , Fernández Ana María 
Published: April 2024

AbstractThe effects of biodiversity on ecological processes have been experimentally evaluated mainly at the local scale under homogeneous conditions. To scale up experimentally based biodiversity‐functioning relationships, there is an urgent need to understand how such relationships are affected by the environmental heterogeneity that characterizes larger spatial scales. Here, we tested the effects of an 800‐m elevation gradient (a large‐scale environmental factor) and forest habitat (a fine‐scale factor) on litter diversity–decomposition relationships. To better understand local and landscape scale mechanisms, we partitioned net biodiversity effects into complementarity, selection, and insurance effects as applicable at each scale. We assembled different litter mixtures in aquatic microcosms that simulated natural tree holes, replicating mixtures across blocks nested within forest habitats (edge, interior) and elevations (low, mid, high). We found that net biodiversity and complementarity effects increased over the elevation gradient, with their strength modified by forest habitat and the identity of litter in mixtures. Complementarity effects at local and landscape scales were greatest for combinations of nutrient‐rich and nutrient‐poor litters, consistent with nutrient transfer mechanisms. By contrast, selection effects were consistently weak and negative at both scales. Selection effects at the landscape level were due mainly to nonrandom overyielding rather than spatial insurance effects. Our findings demonstrate that the mechanisms by which litter diversity affects decomposition are sensitive to environmental heterogeneity at multiple scales. This has implications for the scaling of biodiversity–ecosystem function relationships and suggests that future shifts in environmental conditions due to climate change or land use may impact the functioning of aquatic ecosystems.
Care‐seeking delay of patients with heart failure in China: a mixed‐method study
Authors: Xu Mengqi , Ruan Tiantian , Huang Xiaoli , Han Beibei , Li Yingqi , Ding Yuan , Zhu Lingyan 
Published: April 2024

AbstractAimThis study aims to explore the duration and influencing factors of care‐seeking delay among patients with heart failure (HF) in China.Methods and resultsA convergent mixed method containing a cross‐sectional study and two parts of qualitative studies was designed, following the STROBE and COREQ guidelines. Convenience sampling was applied to recruit patients with HF from two general hospitals from December 2021 to December 2022. Purposive sampling was used to enrol healthcare professionals from two general hospitals and two community hospitals from June to November 2022. Among the 258 patients with HF in the cross‐sectional study, the median duration of care‐seeking delay was 7.5 days. The result integration indicated that the delay duration was influenced by the dyspnoea symptom burden, the oedema symptom burden, and the depression status. The lower dyspnoea symptom burden, the higher oedema symptom burden, and the higher depression score were related to the prolonged care‐seeking delay duration. The duration was also affected by the COVID‐19 pandemic, level of support from medical system, and the symptom management abilities of the caregivers. The COVID‐19 pandemic, low level of support from medical system, and limited symptom management abilities of caregivers were related to the prolonged care‐seeking delay duration.ConclusionsCare‐seeking delay among patients with HF needs attention in China. The duration of care‐seeking delay of patients with HF was influenced by the dyspnoea symptom burden, the oedema symptom burden, and depression status, as well as the COVID‐19 pandemic, level of support from medical system, and the symptom management abilities of the caregivers.
Elucidating the Key Factors in Hydroamination and Defluoroamination Competitions: A DFT Analysis of Reaction between α‐(Trifluoromethyl)styrene and 2‐Pyridones
Authors: Xu Haoran , Zhang Yuchen , Xue Xiao‐Song 
Published: April 2024

Abstractβ‐fluorocarbanions have garnered considerable attention for their dual reactivity in nucleophilic processes and β‐fluorine elimination. In this study, a thorough computational analysis was conducted to explore the reactions of α‐(trifluoromethyl)styrenes with 2‐pyridones to delineate the factors determining protonation or defluorination pathways for the in situ generated β‐fluorocarbanions under varied basic conditions. Our findings illuminate the critical role of organobase basicity in steering the direction of the competitive protonation and β‐fluorine elimination reactions. We propose the use of pKaH values of organobases as a quantitative indicator for discerning the predominant reaction pathways. This provides an efficient approach to predict and control the reaction outcome, facilitating the deliberate design of reactions to leverage the unique reactivity of β‐fluorocarbanions in the realm of fluorine chemistry.