bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review of reasoning characteristics of RDF‐based Semantic Web systems
Authors: Colucci Simona , Donini Francesco M. , Di Sciascio Eugenio 
Published: March 2024

AbstractPresented as a research challenge in 2001, the Semantic Web (SW) is now a mature technology, used in several cross‐domain applications. One of its key benefits is a formal semantics of its RDF data format, which enables a system to validate data, infer implicit knowledge by automated reasoning, and explain it to a user; yet the analysis presented here of 71 RDF‐based SW systems (out of which 17 reasoners) reveals that the exploitation of such semantics varies a lot among all SW applications. Since the simple enumeration of systems, each one with its characteristics, might result in a clueless listing, we borrow from Software Engineering the idea of maturity model, and organize our classification around it. Our model has three orthogonal dimensions: treatment of blank nodes, degree of deductive capabilities, and explanation of results. For each dimension, we define 3–4 levels of increasing exploitation of semantics, corresponding to an increasingly sophisticated output in that dimension. Each system is then classified in each dimension, based on its documentation and published articles. The distribution of systems along each dimension is depicted in the graphical abstract. We deliberately exclude resources consumption (time and space) since it is a dimension not peculiar to SW.This article is categorized under:
Fundamental Concepts of Data and Knowledge > Knowledge Representation
Fundamental Concepts of Data and Knowledge > Explainable AI
Correcting for cutoff dependence in backward evolution of QCD parton showers
Authors: Frixione S. , Webber B. R. 
Published: March 2024

Abstract
Monte Carlo event generators for hard hadronic collisions depend on the evolution of parton showers backwards from a high-scale subprocess to the hadronization scale. The evolution is treated as a branching process with a sequence of resolvable parton emissions. The criterion of resolvability involves cutoffs that determine the no-emission probability (NEP) for a given range of the evolution scale. Existing event generators neglect cutoff-dependent terms in the NEP that, although formally power-suppressed, can have significant phenomenological effects. We compute such terms and study their consequences. One important result is that it is not possible for the backward shower to faithfully reproduce the cutoff-independent parton distribution functions (PDFs) used to generate it. We show that the computed NEP corrections mitigate but do not eliminate this problem. An alternative approach is to use cutoff-dependent PDFs that are consistent with the uncorrected NEP. Then one must apply cutoff-dependent corrections to hard subprocess matrix elements. We compute those corrections to the first nontrivial order for the Drell-Yan process and for Higgs production by gluon fusion.
Cosmology meets cohomology
Authors: De Shounak , Pokraka Andrzej 
Published: March 2024

Abstract
The cosmological polytope and bootstrap programs have revealed interesting connections between positive geometries, modern on-shell methods and bootstrap principles studied in the amplitudes community with the wavefunction of the Universe in toy models of FRW cosmologies. To compute these FRW correlators, one often faces integrals that are too difficult to evaluate by direct integration. Borrowing from the Feynman integral community, the method of (canonical) differential equations provides an efficient alternative for evaluating these integrals. Moreover, we further develop our geometric understanding of these integrals by describing the associated relative twisted cohomology. Leveraging recent progress in our understanding of relative twisted cohomology in the Feynman integral community, we give an algorithm to predict the basis size and simplify the computation of the differential equations satisfied by FRW correlators.
Vitamin A-containing dietary supplements from German and US online pharmacies: market and risk assessment
Authors: Rathmann Anna-Miriam , Seifert Roland 
Published: March 2024

AbstractVitamin A supplements are used by many people, and the number of newly registered dietary supplements is continuously increasing. The preparations fall under food law and are not subject to the strict controls of pharmaceuticals. Risk indications and maximum quantity recommendations, e.g., from the Bundesinstitut für Risikobewertung (BfR) and the U.S. Food and Drug Administration (FDA) are not binding, which means that overdoses and potentially serious health problems can easily occur. The hepatotoxicity and teratogenicity of vitamin A are well documented, and other negative effects of high doses of vitamin A are also being discussed. Nevertheless, preparations with exorbitantly high doses are freely available for sale and unrestricted. In this study, 75 supplements containing vitamin A available in Germany and 26 available in the USA were critically examined on the basis of various parameters such as the recommended daily dose according to the manufacturer, daily therapy costs (DTC), the presence of warnings about overdose, use during pregnancy and breastfeeding, and information on adverse effects/interactions. The aim was to gain insights into their risk potential and to examine the need for closer monitoring and stricter guidelines for these preparations. The results show some considerable country-specific differences. Overall, there are serious deficiencies in compliance with the labeling requirements for both the German and the US preparations, and the dosages are often far too high in view of the applicable expert recommendations. Overall, these deficits can pose a risk for consumers that is difficult to assess in its entirety, especially for vulnerable consumer groups. It should be noted that the US preparations perform better overall than the German preparations. This suggests better regulation of dietary supplements in the US market. Based on the available data and literature research, it is doubtful whether the intake of vitamin A-containing preparations, without a diagnosed vitamin A deficiency, has a positive health benefit. Furthermore, it should be examined whether vitamin A should continue to be offered over-the-counter as a food supplement.
Association between microsatellite status and characteristics and outcomes of early-onset compared to late-onset rectal cancer
Authors: Emile Sameh Hany , Horesh Nir , Garoufalia Zoe , Gefen Rachel , Zhou Peige , Strassmann Victor , Wexner Steven D. 
Published: March 2024

Abstract
Background
Microsatellite instability (MSI) is an important prognosticator for colorectal cancer (CRC). The present study aimed to assess the impact of MSI status on the characteristics and outcomes of early-onset compared to late-onset rectal cancer.

Methods
This retrospective cohort study used data from the US National Cancer Database (2004–2019) to assess the baseline characteristics, treatment patterns, short-term outcomes, and overall survival (OS) of early-onset rectal adenocarcinoma affecting patients < 50 years compared to late-onset rectal adenocarcinoma according to the MSI status.

Results
The present study included 48,407 patients (59.9% male) with rectal cancer, 17.3% of patients were < 50 years and 6.3% had MSI-H tumors. In the early-onset group, patients with MSI-H tumors had a lower mean age (41.5 vs 43 years, p < 0.001) and presented less often with stage IV disease (22.1% vs 17.7%, p = 0.03) and liver metastasis (9.1% vs 13.5%, p = 0.011) than patients with MSS tumors. In the late-onset group, patients with MSI-H and MSS tumors had similar demographics, disease stage, and metastatic pattern, yet MSI-H patients more often received neoadjuvant radiation therapy (58.9% vs 55.1%, p = 0.009) and neoadjuvant systemic therapy (40% vs 36.2%, p = 0.005). In both age groups, MSI-H tumors were associated with more pathologic T3-4 stage and were more likely mucinous and poorly differentiated carcinomas than MSS tumors. The median OS of MSI-H tumors was similar to MSS tumors (108.09 vs 102.31 months, p = 0.1), whether in the early-onset (139.5 vs 134.2 months, p = 0.821) or late-onset groups (106.1 vs 104.3 months, p = 0.236).

Conclusions
In both age groups, MSI-H rectal cancers were more often mucinous and poorly differentiated carcinomas and had pT3-4 stage more often than MSS cancers. MSI-H rectal cancers tend to present less often with distant metastases and nodal involvement than MSS cancers only in early-onset, but not in late-onset rectal cancers. The association between MSI status and survival was not notable in this study, whether in the early-onset or late-onset groups.
Development of a nomogram to predict the prognosis of patients with secondary bone tumors in the intensive care unit: a retrospective analysis based on the MIMIC IV database
Authors: Li Weikang , Li Jinliang , Cai Jinkui 
Published: March 2024

Abstract
Purpose
The present study aimed to develop a nomogram to predict the prognosis of patients with secondary bone tumors in the intensive care unit to facilitate risk stratification and treatment planning.

Methods
We used the MIMIC IV 2.0 (the Medical Information Mart for Intensive Care IV) to retrieve patients with secondary bone tumors as a study cohort. To evaluate the predictive ability of each characteristic on patient mortality, stepwise Cox regression was used to screen variables, and the selected variables were included in the final Cox proportional hazard model. Finally, the performance of the model was tested using the decision curve, calibration curve, and receiver operating characteristic (ROC) curve.

Results
A total of 1028 patients were enrolled after excluding cases with missing information. In the training cohort, albumin, APSIII (Acute Physiology Score III), chemotherapy, lactate, chloride, hepatic metastases, respiratory failure, SAPSII (Simplified Acute Physiology Score II), and total protein were identified as independent risk factors for patient death and then incorporated into the final model. The model showed good and robust prediction performance.

Conclusion
We developed a nomogram prognostic model for patients with secondary bone tumors in the intensive care unit, which provides effective survival prediction information.
Overexpression of Transmembrane Phosphatase with Tensin homology (TPTE) in prostate cancer is clinically significant, suggesting its potential as a valuable biomarker
Authors: Zainodini Nahid , Abolhasani Maryam , Mohsenzadegan Monireh , Farajollahi Mohammad M. , Rismani Elham 
Published: March 2024

Abstract
Purpose
Cancer testis antigens (CTAs) are a family of proteins typically expressed in male testicles but overexpressed in various cancer cell types. Transmembrane Phosphatase with Tensin homology (TPTE) is expressed only in the testis of healthy individuals and is a member of the family of CTAs. The current study, for the first time, examined the significance of TPTE expression in prostate cancer (PCa) tissues by generating a novel antibody marker targeting TPTE protein.

Methods
Polyclonal antibodies were prepared for TPTE-p1 and TPTE-p2 peptides, which are derived from the extracellular domains of TPTE. Anti-TPTE-p2 antibody was then used to study the extent and pattern of TPTE expression in 102 PCa and 48 benign prostatic hyperplasia (BPH) tissue samples by immunohistochemistry. The viability of cancer cell lines (PC-3 and MCF-7 cells) was also evaluated in the presence of anti-TPTE-p2 antibody using the MTT test.

Results
The immunohistochemical analysis demonstrated a significant increase in cytoplasmic and membrane TPTE expression in the PCa samples compared to the BPH group (both P < 0.0001). Cytoplasmic TPTE expression was positively correlated with Gleason score and PSA levels (P = 0.03 and P = 0.001, respectively). Significant correlations were identified between the levels of PSA and perineural invasion and the membrane expression (P = 0.01, P = 0.04, respectively). Moreover, anti-TPTE-p2 antibody inhibited PC-3 and MCF-7 cells proliferation compared to the control group for 24 h (P < 0.001 and P = 0.001, respectively) as well as for 48 h (P = 0.001 and P = 0.001, respectively).

Conclusion
Our findings indicate that increased TPTE expression is associated with progression of disease. The ability of anti-TPTE-p2 antibody to recognize and target the TPTE protein makes it a potential biomarker to assess and/or target the PCa.
The 2023 Guidelines for the management and treatment of glucocorticoid-induced osteoporosis
Authors: Tanaka Yoshiya , Soen Satoshi , Hirata Shintaro , Okada Yosuke , Fujiwara Saeko , Tanaka Ikuko , Kitajima Yuriko , Kubota Takuo , Ebina Kosuke , Takashi Yuichi , Inoue Reiko , Yamauchi Mika , Okubo Naoaki , Ueno Masanobu , Ohata Yasuhisa , Ito Nobuaki , Ozono Keiichi , Nakayama Hisanori , Terauchi Masakazu , Tanaka Sakae , Fukumoto Seiji 
Published: March 2024

Abstract
Introduction
Although synthetic glucocorticoids (GCs) are commonly used to treat autoimmune and other diseases, GC induced osteoporosis (GIOP) which accounts for 25% of the adverse reactions, causes fractures in 30–50% of patients, and markedly decreases their quality of life. In 2014, the Japanese Society for Bone and Mineral Research (JSBMR) published the revised guidelines for the management and treatment of steroid-induced osteoporosis, providing the treatment criteria based on scores of risk factors, including previous fractures, age, GC doses, and bone mineral density, for patients aged ≥18 years who are receiving GC therapy or scheduled to receive GC therapy for ≥3 months.

Materials and methods
The Committee on the revision of the guidelines for the management and treatment of GIOP of the JSBMR prepared 17 clinical questions (CQs) according to the GRADE approach and revised the guidelines for the management and treatment of GIOP through systematic reviews and consensus conferences using the Delphi method.

Results
Bisphosphonates (oral and injectable formulations), anti-RANKL antibody teriparatide, eldecalcitol, or selective estrogen receptor modulators are recommended for patients who has received or scheduled for GC therapy with risk factor scores of ≥3. It is recommended that osteoporosis medication is started concomitantly with the GC therapy for the prevention of fragility fractures in elderly patients.

Conclusion
The 2023 guidelines for the management and treatment of GIOP was developed through systematic reviews and consensus conferences using the Delphi method.
Production of iron-enriched yeast and it’s application in the treatment of iron-deficiency anemia
Authors: Chen Ying , Pang Yuanxiang , Wan Hongbing , Zhou Xinyi , Wan Mingli , Li Shengshuo , Liu Xuelian 
Published: March 2024

AbstractIron deficiency anemia (IDA) is one of the most serious forms of malnutrition. Wild type strains of Saccharomyces cerevisiae have higher tolerance to inorganic iron and higher iron conversion and accumulation capacity. The aim of this study was to investigate the effect of S. cerevisiae enriched iron as a potential organic iron supplement on mice with iron deficiency anemia. 60 male Kunming mice (KM mice, with strong adaptability and high reproduction rate, it can be widely used in pharmacology, toxicology, microbiology and other research) were randomly divided into normal control group and iron deficiency diet model group to establish IDA model. After the model was established, IDA mice were randomly divided into 5 groups: normal control group, IDA group, organic iron group (ferrous glycinate), inorganic iron group (ferrous sulfate) and S. cerevisiae enriched iron group. Mice in the experimental group were given different kinds of iron by intragastric administration once a day for 4w. The results showed that S. cerevisiae enriched iron had an effective recovery function, and the body weight and hematological parameters of IDA mice returned to normal levels. The activities of superoxide dismutase, glutathione peroxidase and total antioxidant capacity in serum were increased. In addition, the strain no. F8, able to grow in an iron-rich environment, was more effective in alleviating IDA and improving organ indices with fewer side effects compared to ferrous glycinate and ferrous sulfate groups. This study suggests that the iron-rich strain no. F8 may play an important role in improving IDA mice and may be developed as a new iron supplement.
Anticipatory governance in government: the case of Finnish higher education
Authors: Kallo Johanna , Välimaa Jussi 
Published: March 2024

Abstract
In response to uncertain times, liberal democracies aspire to develop anticipatory practices that usher in changes in policies and governance. These practices include creating visions and implementing roadmaps, which seek to address, and ultimately preempt, future challenges (Anderson, 2010). While such practices are increasingly implemented today in decision-making in Nordic countries and around the world (Dreyer & Stang, 2013; Beckert & Bronk, 2018; Beerten & Kranke, 2022), their implications are seldom studied, especially in the context of higher education. This article addresses this gap in current research by analyzing the case of the future governance of Finnish higher education. The analysis focuses on the creation of visions and roadmaps, as well as reports anticipating the future needs of higher education. The article investigates how the anticipation of higher education needs has developed and how it is related to current visions. Moreover, it examines the consequences of anticipatory practices in the development of policy and governance and investigates the policy future that will be enacted through these anticipatory practices. The findings show that the anticipation of higher education needs underpins the strategic choices affecting the allocation of resources and the population’s educational levels in the long term, while visions draw actors into the coproduction of future imagining and instigate widespread reforms. Visions and other practices underpin anticipatory governance in higher education, where goals for the long term are established through the negotiation of normative preferences based on a human capital view of the future.
Efficiency improvement by using metal–insulator-semiconductor structure in InGaN/GaN micro-light-emitting diodes
Authors: Yin Jian , Hwang David , Siboni Hossein Zamani , Fathi Ehsanollah , Chaji Reza , Ban Dayan 
Published: March 2024

AbstractInGaN/GaN micro-light-emitting diodes (micro-LEDs) with a metal–insulator-semiconductor (MIS) structure on the sidewall are proposed to improve efficiency. In this MIS structure, a sidewall electrode is deposited on the insulating layer-coated sidewall of the device mesa between a cathode on the bottom and an anode on the top. Electroluminescence (EL) measurements of fabricated devices with a mesa diameter of 10 μm show that the application of negative biases on the sidewall electrode can increase the device external quantum efficiency (EQE). In contrast, the application of positive biases can decrease the EQE. The band structure analysis reveals that the EQE is impacted because the application of sidewall electric fields manipulates the local surface electron density along the mesa sidewall and thus controls surface Shockley–Read–Hall (SRH) recombination. Two suggested strategies, reducing insulator layer thickness and exploring alternative materials, can be implemented to further improve the EQE of MIS micro-LEDs in future fabrication.
Graphical Abstract
Formative Feedback on Student-Authored Summaries in Intelligent Textbooks Using Large Language Models
Authors: Morris Wesley , Crossley Scott , Holmes Langdon , Ou Chaohua , Dascalu Mihai , McNamara Danielle 
Published: March 2024

AbstractAs intelligent textbooks become more ubiquitous in classrooms and educational settings, the need to make them more interactive arises. An alternative is to ask students to generate knowledge in response to textbook content and provide feedback about the produced knowledge. This study develops Natural Language Processing models to automatically provide feedback to students about the quality of summaries written at the end of intelligent textbook sections. The study builds on the work of Botarleanu et al. (2022), who used a Longformer Large Language Model (LLM) to develop a summary grading model. Their model explained around 55% of holistic summary score variance as assigned by human raters. This study uses a principal component analysis to distill summary scores from an analytic rubric into two principal components – content and wording. This study uses two encoder-only classification large language models finetuned from Longformer on the summaries and the source texts using these principal components explained 82% and 70% of the score variance for content and wording, respectively. On a dataset of summaries collected on the crowd-sourcing site Prolific, the content model was shown to be robust although the accuracy of the wording model was reduced compared to the training set. The developed models are freely available on HuggingFace and will allow formative feedback to users of intelligent textbooks to assess reading comprehension through summarization in real time. The models can also be used for other summarization applications in learning systems.
Effect of MnO2-biochar composites on promoting humification during chicken manure composting
Authors: Qi Haishi , Gao Wenfang , Xie Lina , Zhang Guogang , Song Caihong , Wei Zimin , Hu Ning , Li Tong 
Published: March 2024

AbstractThe present study aimed to accelerate the humification and to investigate how MnO2 modification of biochar (MBC) drives the humus formation during composting with chicken manure. In this study, compared with the control group (CK), the addition of MBC caused an increase in the concentration of both humus and humic acid (HA), with a respective enhancement of 29.1% and 37.2%. In addition, MBC also improved the stability of compost products. Hetero two-dimensional correlation spectra further exhibited that the MBC could alter the formation mechanism of humus fractions during composting. Random forest analysis showed that Microbacterium, Bacteroides, Kroppenstedtia, Gracilibacillus, and Lentibacillus were significantly related to humus formation (P < 0.05). MBC enhanced the absolute abundance of these five genera during composting. The structural equation model further confirmed that these five genera could be indirectly involved in humus formation, through the production of aromatic compounds via secondary metabolism. Additionally, these five genera could directly transform organic components into macromolecular humus structures. Therefore, the increase in these five genera might be a direct response to the acceleration of the humification during MBC composting. These findings demonstrate the potential value of MBC in harmless disposal of hazardous biowastes through composting.Highlights

MnO2 modification of biochar changed the formation mechanism of humus fractions.

Key genera involved in humus formation were identified.

Among of MnO2 modification of biochar, key genera and humus formation were revealed.

Graphical Abstract