bluuebunny/crossref_metadata_2025_split huggingface dataset:
Translation and validation of the German version of the FACE-Q paralysis module in adult patients with unilateral peripheral facial palsy
Authors: Moritz Wieta Elin , Volk Gerd Fabian , Kreysa Helene , Guntinas-Lichius Orlando 
Published: March 2024

AbstractThe aim was to develop and validate a German version of the FACE-Q paralysis module, a patient-reported outcome measure to assess health-related quality of life in adult patients with unilateral facial palsy. The FACE-Q craniofacial questionnaire, which includes the paralysis module, was translated. 213 patients with facial palsy completed the German FACE-Q paralysis along with the established FDI and FaCE questionnaires. Regression analyses were performed to examine the relationships between the different FACE-Q domains and patient and therapy characteristics. The FACE-Q scales had high internal consistency (Cronbach’s alpha all > 0.6). High correlations were found between the FACE-Q and the FDI and FaCE (mean rho = 0.5), as well as within the FACE-Q (mean rho = 0.522). Unifactorial influences were found for all domains except Breathing (all p < 0.05). Multivariate independent predictors were found for some FACE-Q domains. Most influential predictors (> 8 subdomains): Patients who received physical therapy scored lower in ten subdomains than those who did not (all p < 0.05). Patients who had surgery scored lower in nine subdomains than patients without surgery (all p < 0.05). The German version of the FACE-Q Paralysis Module can now be used as a patient-reported outcome instrument in adult patients with facial nerve palsy.
An efficient and accurate 2D human pose estimation method using VTTransPose network
Authors: Li Rui , Li Qi , Yang Shiqiang , Zeng Xin , Yan An 
Published: March 2024

AbstractHuman pose estimation is a crucial area of study in computer vision. Transformer-based pose estimation algorithms have gained popularity for their excellent performance and relatively compact parameterization. However, these algorithms often face challenges including high computational demands and insensitivity to local details. To address these problems, the Twin attention module was introduced in TransPose to improve model efficiency and reduce resource consumption. Additionally, to address issues related to insufficient joint feature representation and poor network recognition performance, the enhanced TransPose model, named VTTransPose, replaced the basic block in the third subnet with the intra-level feature fusion module V block. The performance of the proposed VTTransPose model was validated on the public datasets COCO val2017 and COCO test-dev2017. The experimental results on COCO val2017 and COCO test-dev2017 indicate that the AP evaluation index scores of the VTTransPose network proposed are 76.5 and 73.6 respectively, marking improvements of 0.4 and 0.2 over the original TransPose network. Additionally, VTTransPose exhibited a reduction of 4.8G FLOPs, 2M parameters, and approximately 40% lower memory usage during training compared to the original TransPose model. All the experimental results demonstrate that the proposed VTTransPose is more accurate, efficient, and lightweight compared to the original TransPose model.
Development of risk-score model in patients with negative surgical margin after robot-assisted radical prostatectomy
Authors: Yamada Yuta , Fujii Yoichi , Kakutani Shigenori , Kimura Naoki , Sugimoto Kazuma , Hakozaki Yuji , Sugihara Toru , Takeshima Yuta , Kawai Taketo , Nakamura Masaki , Kamei Jun , Taguchi Satoru , Akiyama Yoshiyuki , Sato Yusuke , Yamada Daisuke , Urabe Fumihiko , Miyazaki Hideyo , Enomoto Yutaka , Fukuhara Hiroshi , Nakagawa Tohru , Fujimura Tetsuya , Kume Haruki 
Published: March 2024

AbstractA total of 739 patients underwent RARP as initial treatment for PCa from November 2011 to October 2018. Data on BCR status, clinical and pathological parameters were collected from the clinical records. After excluding cases with neoadjuvant and/or adjuvant therapies, presence of lymph node or distant metastasis, and positive SM, a total of 537 cases were eligible for the final analysis. The median follow-up of experimental cohort was 28.0 (interquartile: 18.0–43.0) months. We identified the presence of International Society of Urological Pathology grade group (ISUP-GG) ≥ 4 (Hazard ratio (HR) 3.20, 95% Confidence Interval (95% CI) 1.70–6.03, P < 0.001), lymphovascular invasion (HR 2.03, 95% CI 1.00–4.12, P = 0.049), perineural invasion (HR 10.7, 95% CI 1.45–79.9, P = 0.020), and maximum tumor diameter (MTD) > 20 mm (HR 1.9, 95% CI 1.01–3.70, P = 0.047) as significant factors of BCR in the multivariate analysis. We further developed a risk model according to these factors. Based on this model, 1-year, 3-year, and 5-year BCR-free survival were 100%, 98.9%, 98.9% in the low-risk group; 99.1%, 94.1%, 86.5% in the intermediate-risk group; 93.9%, 84.6%, 58.1% in the high-risk group. Internal validation using the bootstrap method showed a c-index of 0.742 and an optimism-corrected c-index level of 0.731. External validation was also carried out using an integrated database derived from 3 other independent institutions including a total of 387 patients for the final analysis. External validation showed a c-index of 0.655. In conclusion, we identified risk factors of biochemical failure in patients showing negative surgical margin after RARP and further developed a risk model using these risk factors.
Dynamic performance of functionally graded composite structures with viscoelastic polymers
Authors: Wang Shaoqing , Song Yaqin , Qiao Yanmei , Shao Siyuan , Wang Weigang 
Published: March 2024

AbstractThe functionally graded composite structures with viscoelastic polymers inherits the excellent performance of functionally graded composites and also possesses large damping performance, which has broad application prospects in the aerospace and mechanical engineering fields. However, due to the complexity of the structure itself, there is limited literature available on its theoretical modeling for efficient solutions. To predict its dynamic performance, a simplified dynamic model of the functionally graded composite structures with viscoelastic polymers is established. This model takes into account the displacement transfer relationship between the functional graded composite layer and the viscoelastic polymer layer. The governing differential equations are obtained by applying the Navier method and complex modulus theory. These equations are then solved using the Rayleigh–Ritz method. The validity of the theoretical model is confirmed by comparing it with existing literature and the results obtained from ANSYS software. Additionally, the model that has been developed is used to analyze how the graded index and elastic modulus of the structure, as well as its geometric parameters, affect its vibration and damping characteristics.
Association between statin use and the risk for idiopathic pulmonary fibrosis and its prognosis: a nationwide, population-based study
Authors: Park Jimyung , Lee Chang-Hoon , Han Kyungdo , Choi Sun Mi 
Published: April 2024

AbstractGiven the pleiotropic effects of statins beyond their lipid-lowering effects, there have been attempts to evaluate the role of statin therapy in IPF, but they have shown inconclusive results. Data from the National Health Insurance Service (NHIS) database of South Korea were used to investigate the effects of statin therapy on IPF. The IPF cohort consisted of a total of 10,568 patients who were newly diagnosed with IPF between 2010 and 2017. These patients were then matched in a 1:3 ratio to 31,704 subjects from a control cohort without IPF, with matching based on age and sex. A case–control study was performed to evaluate the association between statin use and the risk for IPF, and the multivariable analysis revealed that statin use was associated with a lower risk for IPF (adjusted OR 0.847, 95% CI 0.800–0.898). Using the IPF cohort, we also evaluated whether statin use at the time of diagnosis was associated with future clinical outcomes. The statin use at the time of IPF diagnosis was associated with improved overall survival (adjusted HR 0.779, 95% CI 0.709–0.856). Further prospective studies are needed to clarify the role of statin therapy in IPF.
Comparison of results obtained using clot-fibrinolysis waveform analysis and global fibrinolysis capacity assay with rotational thromboelastography
Authors: Tsuchida Takumi , Hayakawa Mineji , Kumano Osamu 
Published: March 2024

AbstractGlobal fibrinolysis assays detect the fibrinolysis time of clot dissolution using tissue-type plasminogen activator (tPA). Two such assays, clot-fibrinolysis waveform analysis (CFWA) and global fibrinolysis capacity (GFC) assay, were recently developed. These were compared with rotational thromboelastography (ROTEM). Healthy donor blood samples were divided into four groups based on tPA-spiked concentrations: 0, 100, 500, and 1000 ng/mL. CFWA and GFC fibrinolysis times, including 4.1 µg/mL and 100 ng/mL tPA in the assays, were determined, denoted as CFWA-Lys and GFC-Lys, respectively. Statistical differences were recognized between tPA concentrations of 0 and 500/1000 ng/mL for CFWA-Lys, and 0 and 100/500/1000 ng/mL for GFC-Lys. The correlation coefficients with lysis onset time (LOT) of extrinsic pathway evaluation and intrinsic pathway evaluation in ROTEM were statistically significant at 0.610 and 0.590 for CFWA-Lys, and 0.939 and 0.928 for GFC-Lys, respectively (p-values < 0.0001 for all correlations). Both assays showed significant correlations with ROTEM; however, the GFC assay proved to have better agreement with ROTEM compared with the CFWA assay. These assays have the potential to reflect a hyperfibrinolysis status with high tPA concentrations.
An observational study to identify causative factors for not using hydroxychloroquine in systemic lupus erythematosus
Authors: Manabe Atsushi , Sada Ryuichi Minoda , Miyake Hirofumi , Akebo Hiroyuki , Tsugihashi Yukio , Hatta Kazuhiro 
Published: April 2024

AbstractHydroxychloroquine (HCQ) use is indicated for patients with systemic lupus erythematosus (SLE). Nevertheless, reports discussing the reasons for not prescribing HCQ are limited. We identified the factors that interfere with HCQ use in patients with SLE. This observational, single-center study included data from 265 patients with SLE in 2019. The patients were categorized into groups with and without a history of HCQ use. Between these groups, clinical characteristics were compared using univariate analysis and logistic regression models. Among the 265 patients, 133 (50.2%) had a history of HCQ use. Univariate analysis identified older age; longer disease duration; lower prednisolone dose, clinical SLE disease activity index 2000, and estimated glomerular filtration rate; higher C3 level; and lower anti-double-stranded DNA antibody concentration as HCQ non-use-related variables. Logistic regression models identified a positive association between HCQ non-use and longer disease duration (odds ratio [OR] 1.08), prednisolone dose ≤ 7.5 mg/day (OR 4.03), C3 level ≥ 73 mg/dL (OR 2.15), and attending physician having graduated > 10 years prior (OR 3.19). In conclusion, a longer disease duration, lower prednisolone dose, higher C3 level, and longer time since attending physicians’ graduation correlated with HCQ non-use. Physicians and patients should be educated to facilitate HCQ use despite these factors.
ARGONAUTE10 controls cell fate specification and formative cell divisions in the Arabidopsis root
Authors: El Arbi Nabila , Schürholz Ann-Kathrin , Handl Marlene U , Schiffner Alexei , Hidalgo Prados Inés , Schnurbusch Liese , Wenzl Christian , Zhao Xin’Ai , Zeng Jian , Lohmann Jan U , Wolf Sebastian 
Published: April 2024

AbstractA key question in plant biology is how oriented cell divisions are integrated with patterning mechanisms to generate organs with adequate cell type allocation. In the root vasculature, a gradient of miRNA165/6 controls the abundance of HD-ZIP III transcription factors, which in turn control cell fate and spatially restrict vascular cell proliferation to specific cells. Here, we show that vascular development requires the presence of ARGONAUTE10, which is thought to sequester miRNA165/6 and protect HD-ZIP III transcripts from degradation. Our results suggest that the miR165/6-AGO10-HDZIP III module acts by buffering cytokinin responses and restricting xylem differentiation. Mutants of AGO10 show faster growth rates and strongly enhanced survival under severe drought conditions. However, this superior performance is offset by markedly increased variation and phenotypic plasticity in sub-optimal carbon supply conditions. Thus, AGO10 is required for the control of formative cell division and coordination of robust cell fate specification of the vasculature, while altering its expression provides a means to adjust phenotypic plasticity.
Analysis of Stress Distribution and Displacement Based on the Miniscrew Positions of the Palatal Slope Bone-borne Expander: A Finite Element Study
Authors: Leeisaramas Chakree , Chantarapanich Nattapon , Inglam Samroeng , Insee Kanlaya 
Published: March 2024

Abstract
Objectives This study aimed to investigate the stress distribution pattern of the palatal slope bone-borne expander on the maxillary area according to a different anteroposterior position of anchored miniscrews using finite element analysis.
Materials and Methods Nasomaxillary stereolithography files with three different anteroposterior anchored miniscrew positions of the palatal slope bone-borne expander were determined as model A, B, and C. Each model consists of four supported miniscrews. Model A: two anterior miniscrews were located between the maxillary canine and the first premolar, and two posteriors between the second premolar and the first molar. Model B: two anteriors were between the lateral incisor and the canine, and two posteriors were the same as in model A. Model C: two anteriors were the same as in model A, and two posteriors were distal to the first molar. One turn of expander screws was applied. Maximum principal stress, equivalent elastic strain, equivalent von Mises stress, and transverse displacement were evaluated.
Results The maximum principal stress was mostly found at the bone-miniscrew interface. Model A exhibited an intersecting area of stress between the supported miniscrews. The highest value of principal stress was in model B, while model C showed a uniform distribution pattern. The elastic strain pattern was similar to the principal stress in all models. The highest value of equivalent von Mises stress was located on the expander screw. The largest amount of transverse displacement of teeth was in model A, while model C exhibited a more consistent transverse displacement than other models. Vertical displacement of posterior teeth was also noticed.
Conclusion Based on the result, it revealed that the various anteroposterior miniscrew placements of the palatal slope bone-borne expander had various patterns of stress distribution and resulted in various outcomes. It may be inferred that model A's miniscrew location was advantageous for obtaining expansion quantities, but model C's miniscrew position was advantageous for maintaining consistent biomechanics.
Potency of Hyperbaric Oxygen Therapy on Oral Candidiasis Diabetes Mellitus
Authors: Parisihni Kristanti , Mulawarmanti Dian , Widowati Kharinna 
Published: March 2024

Abstract
Objectives This study aimed to determine the potency of hyperbaric oxygen therapy (HBOT) to the blood glucose level, amount of lymphocytes, and the expression of antibody anti-Candida in oral candidiasis diabetes mellitus.
Materials and Methods Thirty Wistar rats were divided into five groups: K1 normal-control group, while K2, P1, P2, and P3 were diabetes induced by streptozotocin 50 mg/kg body weight. Oral candidiasis was induced by inoculation 0.1 mL Candida albicans ATCC 10321 on dorsum of the tongue. P1 was given nystatin oral suspension, P2 was treated by HBOT 2.4 ATA, 3 × 30 minutes each with a 5-minute interval, and P3 was treated by the combination of nystatin and HBOT. All the treatments were performed for 5 consecutive days. Fasting blood glucose level was examined on glucometer strips, lymphocyte was examined from complete blood count, and the expression of antibody anti-Candida was examined on immunohistochemistry staining
Statistical Analysis Data analyzed by a one-way analysis of variance and least significant difference test with the result of p-value less than 0.05 was considered to be statistically signiﬁcant.
Results HBOT reduced blood glucose level (p > 0.05) increased the amount of lymphocyte (p < 0.05). All treatments reduced the expression of antibody anti-Candida (p < 0.05) with the best result on combination of HBOT with nystatin.
Conclusion HBOT decreased the blood glucose level, increased the amount of lymphocytes, and reduced the expression of antibody anti-Candida in oral candidiasis diabetes mellitus.
Factors Influencing Health Care Professionals' Perceptions of Frequent Drug–Drug Interaction Alerts
Authors: Biady Yasmine , Lee Teresa , Pham Lily , Patanwala Asad , Poon Simon , Ritchie Angus , Burke Rosemary , Penm Jonathan 
Published: March 2024

Abstract
Background Drug–drug interactions (DDIs) remain a highly prevalent issue for patients in both community and hospital settings. Electronic medication management systems have implemented DDI alerts to mitigate DDI-related harm from occurring.
Objectives The primary aim of this study was to explore factors that influence health care professionals' (hospital doctors, hospital pharmacists, general practitioners, and community pharmacists) perceptions and action taken by them in response to DDI alerts.
Methods A qualitative study was conducted using semi-structured interviews between early January and late February 2021. The top 20 most frequently triggered DDI alerts previously identified were used as examples of alert prompts shown to participants.
Results A total of 20 participants were recruited. General practitioners (n = 4) were most likely to consider DDI alerts to be clinically relevant and important, and hospital doctors (n = 4) were most likely to consider these alerts not being clinically relevant nor important. Three main factors were identified to influence health care professionals' perceptions of DDI alerts, which included clinical relevance, visual presentation, and content of alerts.
Conclusion Health care professionals' perceptions of DDI alerts are influenced by multiple factors and considerations are required to create tailored alerts for users and their clinical contexts. Improvement in DDI alerts should be a priority to improve patient medication safety and health outcomes.
In-Hospital Pulmonary Arterial Embolism after Catheter Ablation of Over 45,000 Cardiac Arrhythmias: Individualized Case Analysis of Multicentric Data
Authors: Doldi Florian , Geßler Nele , Anwar Omar , Kahle Ann-Kathrin , Scherschel Katharina , Rath Benjamin , Köbe Julia , Lange Philipp Sebastian , Frommeyer Gerrit , Metzner Andreas , Meyer Christian , Willems Stephan , Kuck Karl-Heinz , Eckardt Lars 
Published: March 2024

Objective and Background Data on incidence of in-hospital pulmonary embolisms (PE) after catheter ablation (CA) are scarce. To gain further insights, we sought to provide new findings through case-based analyses of administrative data.
Methods Incidences of PE after CA of supraventricular tachycardias (SVT), atrial fibrillation (AF), atrial flutter (AFlu), and ventricular tachycardias (VT) in three German tertiary centers between 2005 and 2020 were determined and coded by the G-DRG (German Diagnosis Related Groups System) and OPS (German Operation and Procedure Classification) systems. An administrative search was performed with a consecutive case-based analysis.
Results Overall, 47,344 ablations were analyzed (10,037 SVT; 28,048 AF; 6,252 AFlu; 3,007 VT). PE occurred in 14 (0.03%) predominantly female (n = 9; 64.3%) patients with a mean age of 55.3 ± 16.9 years, body mass index 26.2 ± 5.1 kg/m2, and left ventricular ejection fraction of 56 ± 13.6%. PE incidences were 0.05% (n = 5) for SVT, 0.02% (n = 5) for AF, and 0.13% (n = 4) for VT ablations. No patient suffered PE after AFlu ablation. Five patients (35.7%) with PE after CA had no prior indication for oral anticoagulation (OAC). Preprocedural international normalized ratio in PE patients was 1.2 ± 0.5. Most patients with PE following CA presented with symptoms the day after the procedure (n = 9) after intraprocedural heparin application of 12,943.2 ± 5,415.5 IU. PE treatment included anticoagulation with either phenprocoumon (n = 5) or non-vitamin K-dependent OAC (n = 9). Two patients with PE died after VT/AF ablation, respectively. The remaining patients were discharged without sequels.
Conclusion Over a 15-year period, incidence of PE after ablation is low, particularly low in patients with ablation for AF/AFlu. This is most likely due to stricter anticoagulation management in these patients compared with those receiving SVT/VT ablation procedures and could argue for continuation of OAC prior to ablation. Optimizing periprocedural anticoagulation management should be subject of further prospective trials.
Measuring Indonesian young consumers’ halal purchase intention of foreign-branded food products
Authors: Pradana Mahir , Rubiyanti Nurafni , Marimon Frederic 
Published: March 2024

AbstractThis article is among the few focusing on halal young consumer behavior in Indonesia. The focus is to examine the topic of halal food product purchase intention. Here, we focus specifically on Muslim teenagers in Indonesia to explore whether they still hold on to the halal principle that most Muslims adhere to when consuming food. This research examine their halal awareness based on theory of planned behavior (TPB) theory and compare it to the previous publications so far. To reach this objective, we used quantitative methodology. Our data was acquired from 161 Indonesian young Muslim consumers. Furthermore, the variance-based structural equation modeling and Theory of Planned Behavior (TPB) research model were utilized. Our findings demonstrate that subjective norm and attitude are significant determinants of halal food buying intent. However, perceived behavioral control has not been established as a purchase intention component. Finally, this study provides additional research on halal consumer behavior, focusing on the empirical findings of young Indonesian consumers, especially seen from TPB perspective.
Vertical and horizontal links in constructional networks
Authors: Ungerer Tobias 
Published: April 2024

Abstract
Recent models of constructional networks combine vertical links between schemas and their subtypes with horizontal
links between constructions at the same level of abstraction. It remains unclear, however, whether vertical and horizontal
analyses express distinct information about the network, or whether one can be reformulated in terms of the other. In this paper,
it is argued that vertical and horizontal links do not encode distinct cognitive mechanisms but that they are notational variants
for representing a common notion of constructional similarity. The practical advantages of each notation are outlined, and some
potential objections to the present account are addressed.