bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non‐icteric pancreas head carcinoma fares worse than icteric pancreas head carcinoma
Authors: Yamaguchi Koji , Nishihara Kazuyoshi , Tsuneyoshi Masazumi 
Published: February 2007

AbstractA total of 22 patients with non‐icteric pancreas head carcinoma were retrospectively compared with 61 patients with icteric pancreas head carcinoma. No significant difference was found regarding age, sex, greatest diameter, macroscopic type, microscopic type, stage, lymphatic permeation, perineural infiltration, venous invasion, lymph node metastasis, and the presence of cancer cells at the surgical margins. The main location of pancreas head carcinoma could be divided into two sites: the superior (pericholedochal), and inferior or distal (excholedochal) areas of the pancreas head. Sixteen (73%) of the 22 non‐icteric pancreas head carcinomas were located in the inferior or distal area (excholedochal), while 28 (46%) of the 61 icteric pancreas head carcinomas were situated in the superior portion (pericholedochal) (P < 0.05). One (5%) of the 22 non‐icteric pancreas head carcinomas was small pancreas carcinoma, compared with 11 (18%) of the 61 icteric pancreas head carcinomas. The cumulative 2‐year and 4‐year survival rates of the 22 patients with non‐icteric pancreas head carcinoma were significantly worse than those of the 61 patients with icteric pancreas head carcinoma [7.9% vs. 24.6% (P < 0.05) and 0% vs. 13.4% (P < 0.01)]. These findings suggest that non‐icteric pancreas head carcinomas normally arise in an area far from the biliary tree, and include a greater number of large tumors. Any resulting difficulty and delay in the diagnosis and treatment of this disease will usually lead to a worsening of the clinical course of non‐icteric pancreas head carcinoma. © 1992 Wiley‐Liss, Inc.
Primary hepatic tumours in children: A 26—year review
Authors: Gururangan Sri , O'Meara Anne , Macmahon Corrina , Guiney Edward J. , O'Donnell Barry , Fitzgerald Ray J. , Breatnach Fin 
Published: February 2007

AbstractTwenty‐one children were admitted to a single paediatric institution between 1964–1990 with histologically proven primary liver tumours. The diagnosis was hepatoblastoma (HBL) in 15 patients, hepatocellular carcinoma (HCA) in 2, rhabdomyosarcoma (RMS) in 2, non‐Hodgkin's lymphoma (NHL) in 1, and haemangioendothelioma (HE) in 1. The common presenting clinical features were anaemia, abdominal mass, and abdominal pain. Serum ã‐foetoprotein was useful in establishing a diagnosis in HBL and in monitoring disease activity. Computed tomographic (CT) scan, ultrasound, and angiography were useful preoperative investigations for assessing site and resectability of tumour. There were no survivors in patients with malignant hepatic tumours (n = 10) who had surgery alone prior to 1981. Of 7 patients with HBL diagnosed after 1981 who had adequate surgical resection and chemotherapy, 5(72%) are currently alive and disease free between 15 months and 8 years from diagnosis. We conclude that adequate surgical resection and adjuvant chemotherapy can improve disease free survival for children with HBL. Optimal treatment has yet to be devised for other malignant hepatic tumours. © 1992 Wiley‐Liss, Inc.
The feasibility of hind foot amputation in selected sarcomas of the foot
Authors: Ham S. John , Hoekstra Harald J. , Eisma Willem H. , Oldhoff Jan , Koops Heimen Schraffordt 
Published: February 2007

AbstractThe treatment of foot sarcomas is generally a below knee amputation. In selected sarcomas of the forefoot, however, a transtarsal amputation according to Chopart, a calcaneotibial arthrodesis according to Pirogoff, or a supramalleolar amputation according to Syme can be considered the treatment of choice, leading to an optimal functional outcome. © 1992 Wiley‐Liss, Inc.
An extraskeletal chondrosarcoma arising in the brachial plexus
Authors: Steffen Christina M. , Kennedy Peter J. , Page Jonathan , Dan Noel 
Published: February 2007

AbstractA case of extraskeletal chondrosarcoma of the left brachial plexus is described with emphasis on the diagnostic and therapeutic difficulties of this site. With combination therapy the patient survived 6 years. Recurrent disease in the plexus region and adjacent spinal cord resulted in a painful, flail limb. © 1992 Wiley‐Liss, Inc.
Whole liver intraoperative irradiation after partial hepatectomy produces minimal functional and pathologic lesions
Authors: Bellantone Rocco , Bossola Maurizio , Merrick Hollis W. , Doglietto Giovanni Battista , Ratto Carlo , Minimo Corrado , Crucitti Antonio , Valentini Vincenzo , Morganti Alessio , Cellini Numa , Marano Pasquale , Dobelbower Ralph , Crucitti Francesco 
Published: February 2007

AbstractIntraoperative radiation therapy (IORT) was delivered to remnant rat liver after partial hepatectomy to determine the chronic effects of treatment on survival, blood chemistry, liver weight, and histology. Survival at one year was 100%. Remnant liver weight was markedly increased in all animals. Liver function appeared to be unaltered in all groups and at all observation times. Inflammatory cell infiltration occurred immediately after treatment in ail animals, showing a slight progression until day 45; by day 180 the values had returned to baseline. Vascular changes were seen early in all groups, then progressively decreased; the vascular score was back to baseline at days 180 and 365. Nuclear alterations were observed in both irradiated and nonirradiated hepatic cells; in all cases these were limited to isolated or focal areas of hepatocytes. There was little fibrosis formation and by day 180 all scores were back to baseline. We conclude that the chronic effects of whole liver IORT after one‐third hepatectomy are minimal in the rat and are similar to those observed after surgeryalone. © 1992 Wiley‐Liss, Inc.
Influence of surgical stress on bactericidal activity of neutrophils and complications of infection in patients with esophageal cancer
Authors: Shigemitsu Yuji , Saito Takao , Kinoshita Tadahiko , Kobayashi Michio 
Published: February 2007

AbstractThe association between surgical stress‐related depression in bactericidal activities of neutrophils and the occurrence of postoperative infections was investigated. Bactericidal activities of neutrophils were measured in 19 patients undergoing esophagectomy, 15 gastrectomy, and 16 cholecystectomy. Five patients had complications of infection following esophagectomy. In 45 patients with no postoperative infections, intracellular killing index (KI) and superoxide anion production (SOP) levels decreased on postoperative day 1 while myeloperoxidase (MPO) activity increased on days 1–3. In 5 patients with esophageal cancer and postoperative infections, decreases in KI and SOP were less prominent, as compared to findings in 14 esophageal cancer patients without such problems but the MPO activity decreased on days 1–3. This evidence suggests that postoperative septic complications are not directly associated with surgical stress‐related transient depression of bactericidal activities immediately after surgery but rather with neutrophil‐mediated tissue injuries based on degranulation. © 1992 Wiley‐Liss, Inc.
Transsternal thoracotomy for bilateral pulmonary metastasis
Authors: Shimizu Nobuyoshi , Ando Akio , Matsutani Takashiro , Maruyama Shuichiro , Date Hiroshi , Teramoto Shigeru 
Published: February 2007

AbstractAdvances in the surgical treatment of primary malignancies and the recent chemotherapy have led to an expansion of the surgical treatment of met‐static lung tumors. However, multiple pulmonary metastases are often found and may affect both lungs. It is difficult to reach tumors in the posterior parts of the lung when using a common midsternal approach, especially lesions located in the left lower lobe. We performed transsternal simultaneous bilateral thoracotomy on 10 patients with bilateral lung tumors (9 bilateral metastatic pulmonary tumors and 1 bilateral primary lung cancer). This procedure provides a wide operative field and is an effective method of thoracotomy for patients with bilateral lung tumors. In future, this method should be more actively performed for patients in whom it is indicated. © 1992 Wiley‐Liss, Inc.
Endobronchial brachytherapy: A preliminary experience
Authors: Susnerwala Shabbir S. , Sharma Sanjay , Deshpande Deepak D. , Dinshaw Ketayun A. , Viswanathan Palayamkottai S. 
Published: February 2007

AbstractFourteen patients with malignant airway obstruction were treated with a placement of a flexible nylon catheter for low dose rate manual afterloading Iridium 192 endobronchial brachytherapy using a flexible fibreoptic bronchoscope. Eight patients had obstructive pneumonitis at initial presentation, while 6 cases were recurrences after previous external irradiation. Six evaluable patients of the former group had complete or partial reinflation of lung and were followed by external radiotherapy. Of the latter group, 3 were evaluable and had moderate to good palliation of their symptoms. No complication was observed. The technique is simple and safe with good patient compliance. Further evaluation is indicated to assess its role in the locoregional management of lung cancer. © 1992 Wiiey‐Liss, Inc.
Papillary carcinoma of the thyroid after postpartum thyroiditis
Authors: Van Hoeven Karen H. , Goldstein Marsha , Friedman Elliott 
Published: February 2007

AbstractPostpartum thyroiditis is a benign, often self‐limited cause of thyroid dysfunction. This report describes the first case of papillary carcinoma arising in a woman with postpartum thyroid disease. Both clinicians and pathologists must keep a high index of suspicion in postpartum patients with persistent thyroid abnormalities, even when a previous biopsy may have disclosed benign disease.
Substituting ornithine for arginine in total parenteral nutrition eliminates enhanced tumor growth
Authors: Grossie V. Bruce , Nishioka Kenji , Ajani Jaffer A. , Ota David M. 
Published: February 2007

AbstractTotal parenteral nutrition (TPN) may enhance the growth of some tumors: this enhanced growth is associated with an increase in the erythrocyte polyamine levels. The effect of arginine in TPN on tumor growth was compared with ornithine using rats with a transplantable Ward colon tumor. The relationship of circulating arginine, ornithine, glutamine, and polyamines with tumor growth was investigated. For rats fed chow ad libitum, increasing tumor weights were associated with a linear decrease in the plasma arginine levels which was consistently lower than that of age‐matched non‐tumor bearing (NTB) rats; ornithine and lysine levels were not affected. Subsequent experiments suggest that plasma glutamine levels were also lower in tumor bearing rats. Pair‐fed NTB rats had reduced arginine but not glutamine levels in plasma. TPN regimens with arginine or with ornithine substituted for arginine at two levels (equimolar [Orm‐Em] or isonitrogenous [Orn‐IN]) were given to colon tumor bearing rats for 8 days. The final tumor weight of rats which received the arginine‐containing regimen (19.8 ± 5.7 g, n = 4) (P < 0.05) was significantly greater than the tumor weight of rats fed chow ad libitum (12.1 ± 3.3 g, n = 6). The final tumor weights of Orn‐EM (11.2 ± 2.6 g, n = 4) or Orn‐IN (11.6 ± 0.8 g, n = 6) were similar to the chow‐fed controls. The plasma arginine levels were elevated, compared with the control, when arginine was present in the regimen. The plasma arginine levels of rats which received Orn‐EM or Orn‐IN were lower than the controls. The plasma ornithine levels were not affected by arginine in the regimen but were elevated with increasing levels of ornithine in TPN. Plasma glutamine levels were decreased when arginine was present in the regimen but were elevated when ornithine was substituted for arginine. Erythrocyte putrescine was increased when either arginine or ornithine was included in the TPN regimens. These results demonstrate that while arginine in a parenteral regimen stimulates tumor growth, substituting ornithine for arginine in TPN does not enhance the growth of a transplantable colon tumor. © 1992 Wiley‐Liss, Inc.
A trial of adjuvant chemoimmunotherapy with mitomycin c and ok‐432 for stage III gastric carcinoma
Authors: Arinaga Shinya , Karimine Nobuya , Takamuku Kiyoshi , Nanbara Shigeru , Inque Hiroshi , Abe Ryoji , Watanabe Daisuke , Matsuoka Hideo , Ueo Hiroaki , Akiyoshi Tsuyoshi 
Published: February 2007

AbstractWe previously found that the ability to generate cytotoxic cells induced by in vitro activation of peripheral blood mononuclear cells (PBM) with OK‐432, a bacterial immunopotentiator, was markedly increased following intravenous administration of a single dose of mitomycin C (MMC) in cancer patients. On the basis of this clinical finding, we designed a treatment regimen that consisted of MMC 12 mg/m2 intravenously on day 1 and OK‐432 5 Klinische Einheit (KE) intradermally on days 6, 8, and 11, when the generation of OK‐432 activated killer cells had been shown to be significantly augmented. Then, it was followed by long‐term tegafur. Fifteen patients with stage III gastric carcinoma who had undergone curative resection were treated with the above regimen. The survival of these patients was significantly better than that of 26 comparable stage III patients concurrently treated with MMC 12 mg/m2 alone, followed by long‐term tegafur (P < 0.01). The results indicate that OK‐432 combined with MMC may be effective against stage III gastric carcinoma, when these agents are used probably in an appropriate combination. © 1992 Wiley‐Liss, Inc.
Enucleation of a secondary esophageal mural tumor
Authors: Bakshandeh Norman , Beattie Edward J. , Harvey James C. 
Published: February 2007

AbstractMetastatic tumors to the esophagus have been described as having the imaging characteristics of benign mural tumors such as leiomyomata, but application of enucleation in treating such tumors has not been described. Our report describes long esophageal myotomy and enucleation of tumor for palliation of dysphagia due to a mural tumor originating from a lung primary. © 1992 Wiley‐Liss, Inc.
Regional DNA content heterogeneity in colonic adenocarcinoma: Prognostic significance in patients with liver metastases
Authors: Graham Roger A. , Teague Kim , McLemore Donia , Cleary Karen , El‐Naggar Adel 
Published: February 2007

AbstractWe retrospectively examined by flow cytometry the DNA ploidy pattern in tissue blocks from 25 primary colon adenocarcinomas and their lymph node and liver metastases. Intratumoral heterogeneity was present in 22% of primary tumors and 21% of metastatic liver deposits. Intertumoral heterogeneity, measured between the primary tumor and its lymph node and liver metastases, was 0% and 20%, respectively. Of 24 patients who underwent successful resection of their liver metastases, 8 neoplasms had uniformly diploid DNA content, while 16 tumors had aneuploid DNA pattern in either the primary tumor, the metastases, or both. Five‐year survival was better in the diploid group (38% vs. 7%, P = 0.10 by log rank analysis). Three of eight patients in the diploid group remain free of disease, while all 16 patients with aneuploid cell populations have died of recurrent disease. © 1992 Wiley‐Liss, Inc.
Primary oesophageal carcinoma in teens
Authors: Kumar Arvind , Shukla Nutan K. , Mishra Mahesh C. , Shahi Uday P. , Kapur Brij M. L. 
Published: February 2007

AbstractSeven teenaged patients with primary oesophageal carcinoma, treated at our hospital in the last 6 years are presented and their management discussed. Five patients had localised disease. Three of them underwent total oesophagectomy, one was given radical radiotherapy, and one was lost to follow‐up. Two patients had metastatic disease at presentation. The primary oesophageal carcinoma in this age group may not be so rare as reported in the literature and must be considered in the differential diagnosis of dysphagia. Like their older counterparts, the outcome depends on the stage of the disease and is not influenced by age per se. © 1992 Wiley‐Liss, Inc.
Prognostic profile for patients with pheochromocytoma derived from clinical and pathological factors and DNA ploidy pattern
Authors: Nativ Ofer , Grant Clive S. , Sheps Sheldon G. , O'Fallon Judith R. , Farrow George M. , Van Heerden Jonathan A. , Lieber Michael M. 
Published: February 2007

AbstractEighty‐eight patients with pheochromocytoma and paraganglioma treated over a 28 year period (1960–1987) were studied. Based on clinical course, they were divided into three prognostic groups: benign (n = 57); multiple (n = 12); and metastatic (n = 19). Using clinical data, histopathologic findings, and tumor nuclear DNA content a prognostic profile for each group was constructed. The following variables were studied: age, familial pheochromocytoma, associated endocrine or neoplastic disorders, number and location of the lesion at diagnosis, size of the tumor, and the nuclear DNA ploidy pattern. Of these prognostic factors the most significant to predict a future malignant clinical course were large size and local tumor extension at time of surgery. Family history of pheochromocytoma, associated endocrine disorders, and young age at presentation predicted multiplicity. Old age, absence of familial pheochromocytoma or related endocrine disorders and DNA diploid tumors seem to be favorable findings. Using these variables in combination may be helpful for early identification of patients with malignant, multiple, or benign pheochromocytoma and paraganglioma. © 1992 Wiley‐Liss, Inc.
Primary brain lymphoma after X‐ray irradiation to the scalp for tinea capitis in childhood
Authors: Stein Moshe , Haim N. , Kuten Abraham , Doron Yafa , Ben Arieh Yehudi T. , Cohen Yoram 
Published: February 2007

AbstractA 39‐year‐old male developed primary brain lymphoma 33 years after receiving scalp irradiation for tinea capitis. This is the first reported association between cranial irradiation during childhood and subsequent development of primary brain lymphoma. © 1992 Wiley‐Liss, Inc.
Investigation of colon cancers for human papillomavirus genomic sequences by polymerase chain reaction
Authors: Shah Keerti V. , Daniel Richard W. , Simons Jonathan W. , Vogelstein Bert 
Published: February 2007

AbstractTwo previous studies have reported the presence of human papillomavirus (HPV) genomic sequences in colorectal cancers. We examined DNAs from 50 colorectal tumors for HPV sequences by polymerase chain reaction (PCR), using HPV consensus L1 primers for amplification. The PCR products were screened with a generic HPV probe consisting of amplimers of HPV‐16 and HPV‐18. All tumor DNAs were negative for HPV sequences. These results call into the question the reported association of colorectal cancers with HPVs. © 1992 Wiley‐Liss, Inc.
Axillary node dissection for early breast cancer: Some is good, but all is better
Authors: Moffat Frederick L. , Senofsky Gregory M. , Davis Kevin , Clark Kimberley C. , Robinson David S. , Ketcham Alfred S. 
Published: February 2007

AbstractOptimal management of the axillary lymphatics in breast cancer patients remains a contentious subject. Axillary recurrence, while infrequent, may have very significant clinical consequences in the affected patient. Axillary sampling, partial and total axillary lymphadenectomy, radiotherapy, and surgery plus radiotherapy are discussed with attention to efficacy in prevention of axillary recurrence, accuracy of nodal staging, and morbidity. The incidence of axillary recurrence decreases and accuracy of staging increases with the number of lymph nodes resected. There is little difference in incidence of morbidity between partial and total axillary lymphadenectomy. Radiotherapy is not as effective as lymphadenectomy for regional disease control and, when administered following a surgical staging procedure, increases the risk of lymphedema of the ipsilateral upper extremity and, in patients undergoing breast‐conserving surgery, the ipsilateral breast. We believe that total axillary lymphadenectomy provides optimal regional disease control and axillary staging with morbidity comparable to that of partial lymphadenectomy. © 1992 Wiley‐Liss, Inc.
Heterogeneity in gastric carcinoma with special reference to DNA content and mitotic activity: Histopathologic differentiation
Authors: Saito Atsushi , Korenaga Daisuke , Haraguchi Masaru , Maehara Yoshihiko , Sugimachi Keizo 
Published: February 2007

AbstractDNA ploidy and mitotic activity were microspectrophotometrically investigated in 46 patients with gastric carcinoma. Measurements of DNA content and mitotic index (M.I.) were examined in the mucosal, submucosal, muscularis propria, and serosal layers of tumors, respectively. The frequency of cells with values exceeding hexaploid chromosome (6c) and mitotic counting analysis revealed a significant higher value in serosa, compared with findings in the mucosa. This tendency was not evident in cases of a differentiated type adenocarcinoma but was noted in those with the undifferentiated type. There were 37 tumors (80.0%) with the same DNA distribution patterns in every layer of the stomach (homogeneous DNA ploidy). Heterogeneity of DNA ploidy was observed in nine tumors (20.0%). Carcinoma with a heterogeneous DNA ploidy manifested a significantly higher incidence of metastasis to the lymph nodes than did those with homogeneous type. Characteristically, there was venous permeation preponderance in the differentiated type and peritoneal dissemination preponderance in the undifferentiated type. This evidence of DNA heterogeneity in gastric carcinoma tissues suggests a possible correlation with the metastatic behavior. © 1992 Wiley‐Liss, Inc.
Flow cytometric DNA analysis of hepatic tumours on ultrasound‐guided fine‐needle aspirates
Authors: Russo Antonio , Bazan Viviana , Plaja Sergio , Cajozzo Massimo , Bazan Pietro 
Published: February 2007

AbstractA study was performed on a nonconsecutive series of 51 patients in order to assess the feasibility, reliability, and usefulness of flow cytometric (FCM) DNA analysis of samples obtained from benign and malignant hepatic tumours by means of ultrasound‐guided fine‐needle aspiration (UG‐FNA). Cytological and often histological confirmation of the nature of the lesion was obtained in all cases from an expert pathologist. For FCM DNA analysis in 32 cases, it was also possible to use samples obtained at surgery from the actual tumours. There were no post UG‐FNA complications, either early or late. It was possible to perform FCM DNA analysis on 6/7 (85.7%) of the benign tumour aspirates and all 44 (100%) coming from the malignant tumours. All the benign tumours showed a DNA‐diploid pattern, while the DNA content was aneuploid in 91% of the malignant tumours. Apart from one case, the results of the FCM DNA analysis of the samples removed at surgery were the same as those obtained from the aspirates (97%). FCM DNA analysis on UG‐FNA samples from hepatic tumours is a fairly simple, reproducible, well‐tolerated technique; it does not involve risks if performed by skilled operators and, since it can be easily repeated even on small tumours, it is a suitable method for monitoring hepatic metastases during chemotherapy. © 1992 Wiley‐Liss, Inc.
Posthemipelvectomy hernia
Authors: Kraybill William G. , Standiford Steven B. , Johnson Frank E. 
Published: February 2007

AbstractWe present four patients who developed posthemipelvectomy hernias. Identified etiologic factors include infection at the time of hemipelvectomy, radiation therapy, and excessive weight gain. Two patients were reconstructed using local tissues, and two required prosthetic materials. There were no hernia recurrences, although two patients died of recurrent cancer. © 1992 Wiley‐Liss, Inc.