bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of early nutritional support on postoperative wound healing in patients with complex fractures: A meta‐analysis review
Authors: Bao Lizhen , Chu Ruzai , Zhang Lili , Li Jianchun , Yang Huiming , Pang Huacong 
Published: March 2024

AbstractComplex fractures present significant challenges in orthopaedic surgery, particularly in terms of postoperative wound healing. Nutritional status plays a crucial role in the recovery process, with early nutritional support potentially influencing wound healing outcomes. This meta‐analysis aimed to assess the impact of early nutritional interventions on postoperative wound healing and scar formation in patients with complex fractures. From an initial pool of 1742 articles, 7 studies were selected for analysis. The results revealed that preoperative nutritional support significantly improved early wound healing, as indicated by lower REEDA scores (SMD = −14.06, 95% CI: [−16.79, −11.32], p < 0.01) 1 week post‐surgery. Furthermore, there was a notable reduction in scar formation, as demonstrated by lower Manchester Scar Scale scores (SMD = −25.03, 95% CI: [−30.32, −19.74], p < 0.01) 3 months post‐surgery. These findings highlight the importance of incorporating nutritional strategies into the management of complex fractures to optimize postoperative recovery.
HMOX1 as a therapeutic target associated with diabetic foot ulcers based on single‐cell analysis and machine learning
Authors: Chen Yiqi , Zhang Yixin , Jiang Ming , Ma Hong , Cai Yuhui 
Published: March 2024

AbstractDiabetic foot ulcers (DFUs) are a serious chronic complication of diabetes mellitus and a leading cause of disability and death in diabetic patients. However, current treatments remain unsatisfactory. Although macrophages are associated with DFU, their exact role in this disease remains uncertain. This study sought to detect macrophage‐related genes in DFU and identify possible therapeutic targets. Single‐cell datasets (GSE223964) and RNA‐seq datasets (GSM68183, GSE80178, GSE134431 and GSE147890) associated with DFU were retrieved from the gene expression omnibus (GEO) database for this study. Analysis of the provided single‐cell data revealed the distribution of macrophage subpopulations in the DFU. Four independent RNA‐seq datasets were merged into a single DFU cohort and further analysed using bioinformatics. This included differential expression (DEG) analysis, multiple machine learning algorithms to identify biomarkers and enrichment analysis. Finally, key results were validated using reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR) and Western bolt. Finally, the findings were validated using RT‐qPCR and western blot. We obtained 802 macrophage‐related genes in single‐cell analysis. Differential expression analysis yielded 743 DEGs. Thirty‐seven macrophage‐associated DEGs were identified by cross‐analysis of marker genes with macrophage‐associated DEGs. Thirty‐seven intersections were screened and cross‐analysed using four machine learning algorithms. Finally, HMOX1 was identified as a potentially valuable biomarker. HMOX1 was significantly associated with biological pathways such as the insulin signalling pathway. The results showed that HMOX1 was significantly overexpressed in DFU samples. In conclusion, the analytical results of this study identified HMOX1 as a potentially valuable biomarker associated with macrophages in DFU. The results of our analysis improve our understanding of the mechanism of macrophage action in this disease and may be useful in developing targeted therapies for DFU.
Effectiveness of SCAR‐Q for assessment of incisional SCAR after implant‐based reconstruction in breast cancer patients: Can it be a tool for incision selection?
Authors: Suzuki Misa , Komiya Takako , Asai Maiko , Ayabe Nanako , Hanano Mai , Kawai Yuichiro , Shimada Kazuki , Ishikawa Takashi , Matsumura Hajime 
Published: March 2024

AbstractIncisional scarring is a factor of cosmetic appearance evaluated after breast reconstruction, along with the shape, position, and size of the breast. This study aimed to examine the effect of the incision scar location on patient satisfaction after breast reconstruction. Using the Japanese version of the SCAR‐Q, we assessed the scar appearance, symptoms and psychosocial effects. Plastic surgeons performed assessments using the Manchester Scar Scale. The patients were divided into two groups: those with scars on the margins of the breast (MB group) and those with scars in the breast area (IB group). The results revealed that patients in the MB group reported significantly higher satisfaction with the scar appearance and psychological impact than those in the IB group. However, assessments using the Manchester Scar Scale did not reveal any significant differences between the two groups. In conclusion, this study underscores the importance of patient‐reported outcomes in the evaluation of scar satisfaction after breast reconstruction. Patients tend to prefer and have higher satisfaction with scars along the breast margin, which offers valuable insights into surgical decisions. Further studies with larger and more diverse sample sizes are required for validation.
Eurasian drylands are both evolutionary cradles and museums of Nitrariaceae diversity
Authors: Wu Sheng‐Dan , Peng Huan‐Wen , Lian Lian , Ortiz Rosa Del C. , Erst Andrey S. , Jabbour Florian , Wang Wei 
Published: March 2024

AbstractAimDrylands cover about 41% of Earth's land surface and are home to fragile biota with high levels of endemism. Two hypothetical models, i.e., cradle and museum, have been proposed to account for present‐day species diversity in an ecoregion or biome. We investigated macroevolutionary patterns to test these two different models in Nitrariaceae, a characteristic component of the Eurasian dryland ecosystem. We also used this family to explore the intercontinental disjunct distribution pattern between the deserts of Eurasia and western North America, known as the Madrean–Tethyan disjunction.LocationDrylands in the Northern Hemisphere.TaxonNitrariaceae (Sapindales, Angiosperms).MethodWe sampled all 16 of the currently recognized extant species of Nitrariaceae and 59 species from the eight other families of Sapindales. A fossil‐calibrated phylogeny was generated using 12 fossil constraints. The ancestral range and climate niche of Nitrariaceae were reconstructed, and diversification rates were estimated.ResultsThe most recent common ancestor of Nitrariaceae likely inhabited arid habitats with low rainfall in the temperate zone in the Late Cretaceous, which geographically corresponds to present‐day Central Asia. The western North American Peganum mexicanum split from its Central Asian sister group at approximately 39 Ma. Net diversification rates of Nitrariaceae experienced a significant increase around 11 Ma. Within Sapindales, at least seven arid species originated markedly prior to the Miocene.Main ConclusionsThe North Atlantic land bridge and global cooling climate in the Late Eocene might have driven the formation of the present‐day disjunct distribution of Nitrariaceae between arid Central Asia and western North America. Nitrariaceae originated in the Late Cretaceous and exhibited long‐term climate niche conservatism, but experienced a rapid diversification in the late Miocene of Eurasia in response to orogenetic and climatic changes. These findings suggest that Eurasian drylands serve as both evolutionary cradles and museums for the diversity of Nitrariaceae and likely for other arid‐adapted lineages.
Cognitive behavior therapy for insomnia for untreated hypertension with comorbid insomnia disorder: The SLEEPRIGHT clinical trial
Authors: Sherwood Andrew , Ulmer Christi , Wu Jade Q. , Blumenthal James A. , Herold Emma , Smith Patrick J. , Koch Gary G. , Johnson Kristy , Viera Anthony , Edinger Jack , Hinderliter Alan 
Published: March 2024

AbstractInsomnia and poor sleep are associated with an increased risk of developing cardiovascular disease (CVD) and its precursors, including hypertension. In 2022, the American Heart Association (AHA) added inadequate sleep to its list of health behaviors that increase the risk for CVD. It remains unknown, however, whether the successful treatment of insomnia and inadequate sleep can reduce heightened CVD risk. SLEEPRIGHT is a single‐site, prospective clinical trial designed to evaluate whether the successful treatment of insomnia results in improved markers of CVD risk in patients with untreated hypertension and comorbid insomnia disorder. Participants (N = 150) will undergo baseline assessments, followed by a 6‐week run‐in period after which they will receive cognitive behavior therapy for insomnia (CBT‐I), comprised of 6 hourly sessions with an experienced CBT‐I therapist over a 6‐week period. In addition to measures of insomnia severity, as well as both subjective and objective measures of sleep, the primary outcome measures are nighttime blood pressure (BP) and BP dipping assessed by 24‐h ambulatory BP monitoring (ABPM). Secondary outcomes include several CVD risk biomarkers, including clinic BP, lipid profile, vascular endothelial function, arterial stiffness, and sympathetic nervous system (SNS) activity. Data analysis will evaluate the association between improvements in insomnia and sleep with primary and secondary CVD risk biomarker outcomes. The SLEEPRIGHT trial (ClinicalTrials.Gov NCT04009447) will utilize CBT‐I, the current gold standard treatment for insomnia disorder, to evaluate whether reducing insomnia severity and improving sleep are accompanied by improved biomarkers of CVD risk in patients with untreated hypertension.
Association between glycated hemoglobin and risk of all‐cause mortality in community patients with type 2 diabetes: A prospective cohort study
Authors: He Qingfang , Gao Mingfei , Zhou Xiaoyan , Wang Lixin , Fang Yujia , Hu Ruying 
Published: March 2024

ABSTRACTAims/IntroductionTo analyze the association between HbA1c level and the risk of all‐cause mortality in community patients with type 2 diabetes mellitus, and to provide a scientific basis for the management of type 2 diabetes mellitus in the community.Materials and MethodsBased on a Zhejiang rural community type 2 diabetes mellitus cohort, a total of 10,310 patients with type 2 diabetes mellitus with complete baseline and follow‐up data were selected. The Cox proportional hazards regression model and the restricted cubic spline model were used to evaluate the relationship between the HbA1c level and the risk of all‐cause mortality.ResultsDuring a mean follow‐up of 5.5 years, 971 patients died. With HbA1c levels of 6.5–7.0% as the reference, after adjusting for relevant confounding factors, the HR(95%CI) of all‐cause mortality with HbA1c levels of <5.5%, 5.5–6.5%, 7.0–8.0%, 8.0–9.0%, and ≥9.0% were 1.53 (1.08–2.15), 0.97 (0.79–1.21), 1.14 (0.92–1.41), 1.44 (1.14–1.83), and 2.08 (1.68–2.58), respectively. The HbA1c level was associated with the risk of all‐cause mortality in a “J‐shaped” manner. The risk of all‐cause mortality was lowest when the HbA1c was 6.5–7.0%, and increased significantly when the HbA1c was ≥ 8.0% and the HbA1c was < 5.5% (P < 0.05). The risk of all‐cause death in the HbA1c 5.5–6.5% group and the 7.0–8.0% group was not significant compared with the reference group (P > 0.05).ConclusionsThe HbA1c levels were associated with the risk of all‐cause mortality in type 2 diabetes mellitus in a “J‐shaped” manner, a too high or a too low HbA1c level could increase the risk of death. Attention should be paid to the individual evaluation of patients and the setting of appropriate glycemic control goals.
Dermatological patients with itch report more stress, stigmatization experience, anxiety and depression compared to patients without itch: Results from a European multi‐centre study
Authors: Zeidler C. , Kupfer J. , Dalgard F. J. , Bewley A. , Evers A. W. M. , Gieler U. , Lien L. , Sampogna F. , Tomas Aragones L. , Vulink N. , Finlay A. Y. , Legat F. J. , Titeca G. , Jemec G. B. , Misery L. , Szabó C. , Grivcheva Panovska V. , Spillekom van Koulil S. , Balieva F. , Szepietowski J. C. , Reich A. , Ferreira B. R. , Lvov A. , Romanov D. , Marron S. E. , Gracia Cazaña T. , Elyas A. , Altunay I. K. , Thompson A. R. , van Beugen S. , Ständer S. , Schut C. 
Published: March 2024

AbstractBackgroundItch as the most common symptom in dermatology has been shown to be related to psychological factors such as stress, anxiety and depression. Moreover, associations were found between perceived stigmatization and itch. However, studies investigating the differences between patients with dermatoses with and without itch regarding perceived stress, stigmatization, anxiety and depression are missing. Therefore, one of the aims of the second study of the European Society for Dermatology and Psychiatry (ESDaP study II) was to investigate these relationships in a large cohort of patients with different itchy dermatoses.Results3399 patients with 14 different itchy dermatoses were recruited at 22 centres in 17 European countries. They filled in questionnaires to assess perceived stigmatization, stress, signs of clinically relevant anxiety or depression, itch‐related quality of life, the overall health status, itch duration, frequency and intensity. The most significant association between the severity of itching and the perception of stress was observed among individuals with rosacea (correlation coefficient r = 0.314). Similarly, the strongest links between itch intensity and experiences of stigmatization, anxiety, and depression were found in patients with seborrheic dermatitis (correlation coefficients r = 0.317, r = 0.356, and r = 0.400, respectively). Utilizing a stepwise linear regression analysis, it was determined that within the entire patient cohort, 9.3% of the variation in itch intensity could be accounted for by factors including gender, levels of anxiety, depression, and perceived stigmatization. Females and individuals with elevated anxiety, depression, and perceived stigmatization scores reported more pronounced itch intensities compared to those with contrary attributes.ConclusionThis study underscores the connection between experiencing itch and its intensity and the psychological strain it places on individuals. Consequently, psychological interventions should encompass both addressing the itch itself and the interconnected psychological factors. In specific cases, it becomes imperative for dermatologists to direct individuals towards suitable healthcare resources to undergo further psychological assessment.
Shoals in troubled waters? The impact of rising temperatures on metabolism, foraging, and shoaling behavior in mixed‐species shoals
Authors: Mukherjee Ishani , Bhat Anuradha 
Published: March 2024

AbstractRising water temperatures across aquatic habitats, in the current global climate change scenario, can directly affect metabolism and food intake in fish species. This can potentially alter their physiological, behavioral, and shoaling properties. In the current study, we examined the effects of high temperatures on metabolism, foraging, and shoaling in tropical fish. Mixed‐species (comprising flying barbs, zebrafish, and gambusia) and single‐species (flying barbs and zebrafish) shoals were conditioned for 45 days to three kinds of temperature regimes: the current temperature regime (CTR), in which shoals were maintained at water temperature of 24°C (i.e., the current mean temperature of their habitat), the predicted temperature regime (PTR) at 31°C (i.e., simulating conditions projected for their habitat in 2100), and the dynamic temperature regime (DTR), which experienced daily temperature fluctuations between 24 and 31°C (i.e., resembling rapid temperature changes expected in their natural environments). We found species‐specific responses to these temperature regimes. Flying barbs exhibited significantly lower body weight at PTR but maintained consistent muscle glycogen content across all temperature regimes. In contrast, zebrafish and gambusia displayed significantly elevated muscle glycogen content at PTR, with similar body weights across all three temperature regimes. Cohesion within flying barb shoals and cohesion/polarization in mixed‐species shoals decreased significantly at PTR. Shoals exposed to DTR exhibited intermediate characteristics between those conditioned to CTR and PTR, suggesting that shoals may be less impacted by dynamic temperatures compared to prolonged high temperatures. This study highlights species‐specific metabolic responses to temperature changes and their potential implications for larger‐scale shoal properties.
Variable trends in the distribution of Atlantic cod (Gadus morhua) in the Celtic seas
Authors: Ellis Jonathan V. , Schuchert Pia , Scantlebury D. Michael , Marshall C. Tara , Fernandes Paul G. 
Published: March 2024

AbstractDespite decades of active fisheries management, many stocks of Atlantic cod in its southern range are in a depleted state and mortality estimates remain high. Recovery of these stocks, as defined by management areas, could be confounded by cod distributions shifting outside of these areas. Here, we assess data from internationally coordinated trawl surveys to investigate the distribution of three cod stocks in the Celtic Seas ecoregion, Irish Sea, Celtic Sea, and West of Scotland, from 1985 to 2021. We mapped cod densities, analyzed trends in mean weighted depth and bottom temperature, and calculated the center of gravity and equivalent area of the stocks. The distribution of the West of Scotland stock shifted north and east, spilling into the North Sea, while the Irish Sea and Celtic Sea stocks shifted west. Each stock showed decreasing trends in equivalent area, but there were no clear trends in the average depth occupied by the fish. There was no apparent relationship between temperature and the distribution of cod, as bottom temperature varied little from 1993 to 2021. Although Irish Sea cod showed a shift into warmer water, this was due to changes in survey distribution. The shift in distribution of the West of Scotland cod stock towards the North Sea whilst impairing local recovery provides further justification for the recent definition of its incorporation into a larger stock unit that includes the northwest of the North Sea. The Irish Sea and Celtic Sea cod stocks are neither shifting northwards, nor into deeper waters, but remained within current boundaries. This suggests that recent temperature conditions did not affect their distribution, but this may change as temperatures increase towards the limit for reproduction.
Mass, enthalpy, and chemical‐derived emission flows in mineral processing
Authors: Kane Seth , Miller Sabbie A. 
Published: March 2024

AbstractThe production of materials from mineral resources is a significant contributor to anthropogenic CO2 emissions. This contribution is driven primarily by chemical CO2 emissions from the conversion of mineral resources and emissions tied to energy demands for material processing. In this work, we synthesize the thermodynamically required enthalpy and chemically derived emissions of mineral processing and consumption in the United States. We quantify mass, enthalpy, and emissions flows for minerals described by the US Geological Survey, with 882 mass flows and 155 chemical reactions analyzed. In total, 503 PJ of enthalpy is thermodynamically required for 398 Mt of chemically converted material consumption in the United States, resulting in 129 Mt of chemically derived CO2 emissions. Additionally, 249 PJ of fuel resources such as coke are stoichiometrically required for the chemical conversion of minerals. These enthalpy requirements and CO2 emissions are primarily from high‐mass consumption materials such as cement, carbon steel, fertilizer, and aluminum. Cumulatively, the dataset synthesized in this work provides a complete view of the chemical requirements of mineral processing and can aid in guiding decarbonization or sustainable growth in critical minerals sectors, including construction materials and materials for energy storage or generation.
Effects of sensory test conditions and cooking methods on consumer acceptance, sensory profiling, and emotional response of home meal replacement foods
Authors: Oh Jungmin , Heo JeongAe , Park Seyeong , Lim Manyoel , Kwak Han Sub 
Published: March 2024

AbstractThe increased demand for home meal replacement (HMR) foods due to demographic changes requires research focusing on sensory evaluation. This study compares consumer acceptance, sensory profile, and emotional response of HMR based on test conditions (central location test; CLT or home‐use test; HUT) and cooking methods (microwave or pan cooking). The sensory evaluation involved 204 panels, and significant differences were observed in acceptance ratings between CLT and HUT (p < .05). Texture liking was the only significantly different attribute between cooking methods (p < .05). Sensory profiling indicated highly similar characteristics across test conditions and cooking methods. Emotional responses varied depending on the test conditions and cooking methods. In the HUT, positive emotions such as ‘active,’ ‘enthusiastic,’ and ‘happy’ were stronger than those in the CLT (p < .05). Active and positive attitudes such as ‘adventurous,’ ‘aggressive,’ ‘enthusiastic,’ ‘interested,’ and ‘wild’ were stronger in microwave cooking than in pan cooking (p < .05). The results showed that the ‘IKEA effect’ exists in the self‐cooking process, leading to higher liking scores and positive emotions in the HUT compared to the CLT, while intrinsic sensory qualities of the samples were unaffected by external factors, test conditions, and cooking methods.Practical applicationsOur research findings provide practical cooking guidelines for food developers who aim to enhance consumers' acceptance and evoke positive emotions during HMR food cooking. In addition, it was shown how the cooking process affects the evaluation of the products in liking, sensory profiling, and emotional responses by comparing CLT and HUT conditions.
Malignant peripheral nerve sheath tumour of the cerebellopontine angle in a cat
Authors: Çetin M. N. , Şirin Y. S. , Milletsever A. , Şirin M. Y. , Ipek V. 
Published: March 2024

Malignant peripheral nerve sheath tumour is an uncommon tumour in cats. The current case report aims to present the diagnosis, treatment and histopathology of a malignant peripheral nerve sheath tumour that developed in the cerebellopontine angle region of a cat. A 4‐year‐old 4.2‐kg female calico cat was brought to the animal hospital with the complaints of loss of balance, leaning against the wall and behavioural changes. During the neurological examination, the patient was observed to have a right‐sided head tilt accompanied by ipsilateral ventral strabismus. On magnetic resonance imaging scan, a mass was identified at the right cerebellopontine angle. The surgical removal of the mass was carried out using a caudo‐tentorial approach. The histopathological analysis revealed the presence of a malignant peripheral nerve sheath tumour. This case report contributes to the existing knowledge in the field presenting the characteristics of a malignant peripheral nerve tumour that was not associated with any nerve in the cerebellopontine angle in a cat.