bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of rehabilitation interventions on functioning in patients with hemophilic arthropathy: A systematic review with meta-analysis
Authors: Lippi Lorenzo , de Sire Alessandro , Turco Alessio , Santi Roberto Mario , Polverelli Marco , Ammendolia Antonio , Follenzi Antonia , Invernizzi Marco 
Published: April 2024

BACKGROUND: Hemophilic arthropathy is a detrimental condition that crucially affects functional outcomes in hemophilic patients. In recent years, due to the advances in systemic therapies, growing attention has been raised in the rehabilitation field in order to improve functional outcomes of hemophilic patients. However, the optimal rehabilitation modalities in these patients are far from being fully characterized. OBJECTIVE: The present study aimed to assess the effects of different rehabilitation interventions on physical functioning and health-related quality of life of hemophilic arthropathic patients. METHODS: The review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Five databases were systematically searched for randomized controlled trials (RCTs) published until June 22nd, 2023. The selection criteria included adult patients with hemophilia A and B receiving rehabilitation interventions. The outcomes were muscle strength, physical function, pain intensity, physical performance, and health-related quality of life. RESULTS: Out of 1,743 identified records, 17 studies were included in the qualitative synthesis. Rehabilitation interventions were categorized into exercise intervention, fascial therapy, and multimodal intervention. The findings suggested positive outcomes in terms of muscle modifications, range of motion improvements, joint health enhancements, pain intensity reduction, and quality of life improvements. More in detail, meta-analyses showed significant improvements in pain intensity [ES: -1.10 cm (-1.37, -0.82), p< 0.00001], joint health [ES: -1.10 (-1.38, -0.82), p< 0.00001], In accordance, exercise interventions showed significant benefits in terms of joint health [ES: -2.54 (-3.25, -1.83), p< 0.00001)] and quality of life [ES: 1.17 (0.48, 1.86), p< 0.0000)]. CONCLUSION: Rehabilitation interventions have a positive impact on functional outcomes and health-related quality of life of hemophilic arthropathic patients. Further studies are needed to better elucidate the role of a comprehensive intervention combining different rehabilitation approaches to treat hemophilic arthropathy.
Comparison of psoas major activation during standing hip flexion between chronic low back pain and healthy populations
Authors: Cai Congcong , Gazali Nurul Adliah , Tan Xin Ning , Soon Benjamin , Lee Adrian Thian Huat , Aw Qian Wen Simone , Dana Dharini D/O , Kwok Joanne Ching Tung , Kwa Mei Jun 
Published: April 2024

BACKGROUND: The psoas major (PM) has been identified as a potential contributor to chronic low back pain (LBP). However, few studies have investigated the effects of upright functional movement on PM activation in cLBP individuals. OBJECTIVE: This cross-sectional study aims to compare PM muscle activation characteristics in chronic LBP (cLBP) and healthy subjects during the transition from quiet double-leg standing to standing hip flexion. METHODS: Ultrasound Imaging was used to assess PM thickness at the lumbar vertebral level of L4–5 in 12 healthy and 12 cLBP participants. The changes in thickness between the test positions were utilized as a proxy for PM activation. RESULTS: The cLBP group exhibited greater thickness changes on the non-dominant side PM during contralateral hip flexion but not ipsilateral hip flexion (p= 0.369) compared to their healthy counterparts (p= 0.011; cLBP: resting 27.85 mm, activated 34.63 mm; healthy: resting 29.51 mm, activated 29.00 mm). There were no significant differences in dominant side PM thickness changes between the two groups during either contralateral or ipsilateral hip flexion (p= 0.306 and p= 0.077). CONCLUSION: Our findings suggest a potential overactivation of the PM in the cLBP population. This insight may aid in the development of tailored rehabilitation programs.
PENGARUH FREE CASH FLOW TERHADAP MANAJEMEN LABA
Authors: Nasuki Ina 
Published: April 2024

Laba atau keuntungan diperlukan oleh perusahaan untuk dapat melangsungkan kehidupan perusahaan. Pada suatu laporan keuangan perusahaan, laba merupakan salah satu informasi potensial yang sangat penting baik untuk pihak internal perusahaan maupun pihak eksternal perusahaan, namun informasi laba tidak selamanya akurat karena terkadang informasi laba sering digunakan sebagai target memanipulasi melalui tindakan oportunis manajemen dalam memenuhi kepuasannya. Penelitian ini bertujuan untuk menguji pengaruh Free Cash Flow terhadap Manajemen Laba pada perusahaan-perusahaan di Indonesia yang terdaftar di Indeks LQ-45. Pengumpulan data menggunakan metode purposive sampling terhadap perusahaan yang terdaftar dalam Indeks LQ-45 selama 2016-2017. Terdapat 40 perusahaan yang konsisten terdaftar dalam Indeks LQ-45 2016-2017 jumlah keseluruhan sampel dalam penelitian ini yaitu 80 sampel. Langkah utama yang dilakukan dalam penelitian adalah uji asumsi klasik dilakukan terlebih dahulu lalu melakukan Uji Chow, Uji Hausman. Hasil penelitian analisis parsial menunjukan free cash flow memiliki pengaruh positif dan signifikan terhadap terhadap manajemen laba pada perusahaan LQ 45 periode 2016-2017
Chronic Child Malnutrition in Ecuador and Associated Risk Factors
Authors: Moreira-Moreira Zoila , Guevara-Cando Denise , Paredes-Oñate Gabriela , Cabezas-Lucio Ángel , Nazareno-Valencia Yimy , Villacis-Aveiga Marlon , Avellán-Cevallos Génesis , Prieto-Cuesta Emma , Valle-Hidalgo María , Hector Guerrero-Maila  
Published: April 2024

Chronic child malnutrition worldwide is responsible for 45% of deaths in children under 5 years of age. In Ecuador, 27.2% of children suffer from any type of malnutrition. This problem has alarming consequences since it affects the country's productivity and has an impact throughout the individual's life, since at this stage the greatest impact is suffered by the child's brain, in which irreversible metabolic and structural alterations occur. However, child malnutrition is not only a problem of lack of food, it is a deeper social conflict that must be considered when providing solutions. A nationally representative sample of children under 5 years of age from the National Health and Nutrition Survey 2018 (ENSANUT) was used. A binary logistic linear regression model was used where Odds Ratio (OR) with their 95% confidence intervals (95% CI) were estimated for each of the independent variables. Our results reveal that family income reduces the probability of child malnutrition by 2.03 times. In addition, micronutrient intake during 6 months to 2 years of age reduces the probability of child malnutrition by 2.32 times (OR= -1.91 ; -3.02). This result is statistically significant (p<0.05). On the other hand, unemployment, being out of the labor force (in the mother) having a greater number of children at home, working more hours and being a migrant mother also positively predicts the probability of suffering from chronic child malnutrition. Malnutrition is one of the main health problems in Ecuador. It affects a significant percentage of the population and, associated with other factors, is responsible for most of the avoidable mortality and considerable damage to children's health. For this reason, strategies should include epidemiological surveillance, promotion.
TÜRKİYE’DE YAŞLI BİREYLERİN BEDEN ÖLÇÜLERİNE UYGUN OTURMA ELEMANI TASARIMI
Authors: Özkaya Kadir , Özgün Başıbüyük Gülüşan , Dizel Taner 
Published: April 2024

Bir mekan için seçilen mobilyaların, mekanı kullanacak insanların yaşam biçimine uygun olması son derece önemlidir. Yaşlı bireylerin iç mekanlarda karşılaşılacağı fiziksel sınırlamalara yanıt veren ürünler, onlara günlük yaşam aktivitelerini gerçekleştirmede daha çok yardım etmekte, fiziksel ve zihinsel olarak yaşamlarında destekleyici nitelikte bir rol oynamaktadır. Yaşlılık döneminde kemiğin daha kırılgan olması nedeniyle ev kazalarında yaşlı bireyler daha fazla zarar görmektedirler. Bu nedenle yaşlı bireylerin bağımsızlığını arttırmak ve kaza oranını düşürmek için gerek mimari gerekse konut içi düzenleme açısından pek çok faktörün dikkate alınması gereklidir. Bu faktörlerden birisi de yaşlının yaşam kalitesini arttırmaya yardımcı mobilyaların tasarlanmasıdır.
Yaşlı bireyler, hareket kısıtları arttıkça, günlük yaşamlarını çoğunlukla evlerinde geçirmektedirler. Konut içerisinde geçirilen zaman arttıkça yemek yeme, banyo yapma, giyinme gibi zorunlu eylemler dışında; TV izleme, kitap okuma gibi vakit geçirmeye yönelik eylemler için daha fazla hareket edilmektedir. Bu eylemler için yaşlı bireylerin konut içerisinde dinlenme alanı ihtiyacı olmaktadır. Dinlenmek amacıyla koltuk, yatak gibi mobilyalar kullanılabilir. Oturma ve uzanma aktiviteleri sırasında dayanma, çekme hareketleri ile bütün vücut ağırlıklarını mobilyaya vermeleri nedeniyle kullanılacak mobilyalar, kazaya neden olmayacak şekilde sağlam ve ergonomik özelliklere sahip olmalıdır.
Bu çalışmada; yaşlıların ev içerisinde yoğun olarak yaptıkları TV izleme, dinlenme, gazete okuma gibi faaliyetleri zorlanmadan yapabilecekleri ergonomik oturma elemanı tasarımları çalışılmıştır. Bunun için TÜBİTAK tarafından desteklenen proje (P.No: 115M548) ile Türkiye’de farklı bölgelerde yaşayan yaşlı bireylerden alınan antropometrik veriler kullanılmıştır. Elde edilen verilere göre; Türkiye’de yaşayan yaşlı bireyler için ergonomik oturma elemanları tasarımları yapılmıştır. Böylece yaşlı bireyin gün içerisinde sıklıkla tekrarladığı oturma ve kalkma sırasında olabilecek bedensel zorlanmalar azaltılarak, yaşam kalitesinin arttırılması amaçlanmıştır.
PENERAPAN MODEL FOLKLORISTICS DWIBAHASA UNTUK PENGEMBANGAN KONTEN VIRTUAL REALITY TARI LENGGER LANANG
Authors: Nugroho Raden Arief , Yusianto Rindra , Darma Etika Kartika , Muqoddas Ali , Suryaningtyas Valentina Widya , Utami Tin 
Published: April 2024

Abstrak Salah satu permasalahan yang dialami Rumah Lengger Banyumas adalah berkurangnya minat generasi muda usia produktif di Banyumas yang menyukai dan mendalami tari Lengger Lanang. Padahal, tari tersebut adalah tari khas Banyumas yang tidak dijumpai di daerah lain. Jika kondisi ini berlanjut, tari Lengger terancam punah. Rumah Lengger Banyumas, sebagai salah satu pusat pelestari tari Lengger Lanang, belum mampu menghadirkan inovasi kreatif untuk menarik perhatian generasi muda ini. Dengan menggunakan metode Multimedia Development Life Cycle (MDLC), para peneliti mengembangkan virtual reality (VR) berbasis model folkloristics untuk memuat konten tari Lengger Lanang, sejarah, dan filosofinya. Melalui model ini, VR Rumah Lengger Banyumas memuat kisah dari Mbok Dariah yang dikisahkan secara nyata, namun ditambah dengan unsur-unsur dramatis. Sebagai narator di VR ini, para peneliti menciptakan karakter animasi fiktif wayang Lengger Banyumasan untuk memperkuat ikon Kota Banyumas. Kata Kunci: Banyumas, dwibahasa, folkloristics, Lengger Lanang, virtual reality AbstractOne of the problems experienced by Rumah Lengger Banyumas is the decreasing interest of the young generation, especially those in productive age in Banyumas who are interested in learning or studying Lengger Lanang dance. To make things more complicated, this dance is a typical Banyumas dance that is not found in other areas. If this condition continues, Lengger dance is at stake. Rumah Lengger Banyumas, as the center for preserving Lengger Lanang dance, has not been able to present creative innovations to attract the attention of this young generation. Using the Multimedia Development Life Cycle (MDLC) method, the researchers developed a virtual reality (VR) application which also intertwines folkloristics model in order to creatively describe the history and philosophy of Lengger Lanang dance. The VR contains the real story of Mbok Dariah, but added with dramatic narratives. As the narrator in this VR, the researchers created a fictional animated character of Lengger Banyumasan shadow puppet in order to strengthen the icon of Banyumas City. Keywords: Banyumas, bilingual, folkloristics, Lengger Lanang, virtual reality
Analisis Efisiensi Alokatif Penggunaan Faktor Produksi pada Usaha Perkebunan Cengkeh Kabupaten Kolaka
Authors: Kananlua Anriani belo , Bafadal Azhar , Indarsyih Yusna 
Published: April 2024

Mengkaji karakteristik produksi dan tingkat efisiensi yang berdampak pada usaha
perkebunan cengkeh di Kecamatan Baula Kabupaten Kolaka menjadi tujuan utama penelitian ini. Untuk mengetahui faktor-faktor apa saja yang mempengaruhi produksi pada usaha perkebunan cengkeh, penelitian kuantitatif ini menggunakan fungsi produksi Cobb-Douglas yang dipadukan dengan metode pengujian regresi linier berganda. Untuk mengetahui seberapa efisien alokatif faktor-faktor tersebut, peneliti juga menggunakan rumus efisiensi alokatif. Dari total populasi 131 petani, 56 orang dipilih sebagai responden melalui prosedur seleksi acak sederhana berdasarkan rumus Slovin. Menurut penelitian, usaha perkebunan cengkeh dipengaruhi oleh unsur produksi luas lahan dan tenaga kerja. Terdapat inefisiensi dalam alokasi variabel produksi seperti luas lahan dan tenaga kerja.
Adipose-derived stem cells derived decellularized extracellular matrix enabled skin regeneration and remodeling
Authors: Zhang Jin , Xiang Yang , Yang Quyang , Chen Jiqiu , Liu Lei , Jin Jian , Zhu Shihui 
Published: April 2024

The tissues or organs derived decellularized extracellular matrix carry immunogenicity and the risk of pathogen transmission, resulting in limited therapeutic effects. The cell derived dECM cultured in vitro can address these potential risks, but its impact on wound remodeling is still unclear. This study aimed to explore the role of decellularized extracellular matrix (dECM) extracted from adipose derived stem cells (ADSCs) in skin regeneration.Methods: ADSCs were extracted from human adipose tissue. Then we cultivated adipose-derived stem cell cells and decellularized ADSC-dECM for freeze-drying. Western blot (WB), enzyme-linked immunosorbent assay (ELISA) and mass spectrometry (MS) were conducted to analyzed the main protein components in ADSC-dECM. The cell counting assay (CCK-8) and scratch assay were used to explore the effects of different concentrations of ADSC-dECM on the proliferation and migration of human keratinocytes cells (HaCaT), human umbilical vein endothelia cells (HUVEC) and human fibroblasts (HFB), respectively. Moreover, we designed a novel ADSC-dECM-CMC patch which used carboxymethylcellulose (CMC) to load with ADSC-dECM; and we further investigated its effect on a mouse full thickness skin wound model.Results: ADSC-dECM was obtained after decellularization of in vitro cultured human ADSCs. Western blot, ELISA and mass spectrometry results showed that ADSC-dECM contained various bioactive molecules, including collagen, elastin, laminin, and various growth factors. CCK-8 and scratch assay showed that ADSC-dECM treatment could significantly promote the proliferation and migration of HaCaT, human umbilical vein endothelia cells, and human fibroblasts, respectively. To evaluate the therapeutic effect on wound healing in vivo, we developed a novel ADSC-dECM-CMC patch and transplanted it into a mouse full-thickness skin wound model. And we found that ADSC-dECM-CMC patch treatment significantly accelerated the wound closure with time. Further histology and immunohistochemistry indicated that ADSC-dECM-CMC patch could promote tissue regeneration, as confirmed via enhanced angiogenesis and high cell proliferative activity.Conclusion: In this study, we developed a novel ADSC-dECM-CMC patch containing multiple bioactive molecules and exhibiting good biocompatibility for skin reconstruction and regeneration. This patch provides a new approach for the use of adipose stem cells in skin tissue engineering.
Non-linear associations of atherogenic index of plasma with prediabetes and type 2 diabetes mellitus among Chinese adults aged 45 years and above: a cross-sectional study from CHARLS
Authors: Jiang Luqing , Li Lei , Xu Zichen , Tang Yu , Zhai Ying , Fu Xia , Liu Daoqin , Wu Qiwen 
Published: April 2024

BackgroundDyslipidemia is strongly associated with the development of prediabetes and type 2 diabetes mellitus (T2DM). The atherogenic index of plasma (AIP), as a comprehensive index for assessing lipid metabolism, has received extensive attention from researchers in recent years. However, there are relatively few studies exploring the relationships between AIP and the risk of prediabetes and T2DM in the Chinese population. This study focuses on exploring the relationships of AIP with the risk of prediabetes and T2DM in the Chinese population.MethodsWe conducted an analysis of the public data from the China Health and Retirement Longitudinal Study (CHARLS), involving a total of 12,060 participants aged 45 years and above in China. The study explored the relationships of AIP with prediabetes and T2DM risk through multivariate logistic regression, subgroup analysis, smooth curve fitting, and threshold effect analysis.ResultsAfter adjusting for potential confounding factors, we observed positive associations between AIP and the risk of prediabetes [odds ratio (OR) = 1.75, 95% confidence interval (CI): 1.49–2.06] and T2DM (OR = 2.91, 95% CI: 2.38–3.57). Participants with higher AIP levels demonstrated a significantly elevated risk of prediabetes (OR = 1.52, 95% CI: 1.33–1.74) and T2DM (OR = 2.28, 95% CI: 1.92–2.71) compared to those with lower AIP levels. AIP showed consistent correlations with prediabetes and T2DM risk in different subgroups. The results showed the non-linear relationships between AIP and risk of prediabetes and T2DM, with inflection points at 0.29 and −0.04, respectively. When AIP &gt; 0.29, there was a positive association between AIP and the risk of prediabetes (OR = 2.24, 95% CI: 1.67–3.00, p &lt; 0.0001). Similarly, when AIP &gt; −0.04, AIP was positively associated with the risk of T2DM (OR = 3.33, 95% CI: 2.67–4.16, p &lt; 0.0001).ConclusionsThis study demonstrated non-linear positive associations of AIP with the risk of prediabetes and T2DM among participants ≥ 45 years of age in China.
Assessment of new-onset heart failure prediction in a diabetic population using left ventricular global strain: a prospective cohort study based on UK Biobank
Authors: Chen Siwei , Chen Cong , Zheng Longxuan , Cheng Wenke , Bu Xiancong , Liu Zhou 
Published: April 2024

BackgroundImpaired glucose utilization influences myocardial contractile function. However, the prognostic importance of left ventricular global radial strain (LV-GRS), left ventricular global circumferential strain (LV-GCS), and left ventricular global longitudinal strain (LV-GLS) in predicting new-onset heart failure (HF) in a population with diabetes is unclear.MethodsThe study design is prospective cohort from the UK Biobank. Totally 37,899 participants had a complete data of cardiac magnetic resonance (CMR), of which 940 patients with diabetes were included, and all the participants completed follow-up. LV-GRS, LV-GCS, and LV-GLS were measured by completely automated CMR with tissue tagging. Cox proportional hazards regression analysis and C-index was performed to evaluate the association between the strain parameters and the new-onset HF in patients suffering from diabetes.ResultsThe average age of the 940 participants was 57.67 ± 6.97 years, with males comprising 66.4% of the overall population. With an average follow-up period of 166.82 ± 15.26 months, 35 (3.72%) patients reached the endpoint (emergence of new-onset HF). Significant associations were found for the three strain parameters and the new-onset HF (LV-GRS—hazard ratio [HR]: 0.946, 95% CI: 0.916-0.976; LV-GCS—HR: 1.162, 95% CI: 1.086-1.244; LV-GCS—HR: 1.181, 95% CI: 1.082-1.289). LV-GRS, LV-GCS, and LV-GLS were closely related to the related indicators to HF, and showed a high relationship to new-onset HF in individuals with diabetes at 5 and 10 years: LV-GRS: 0.75 (95% CI, 0.41-0.94) and 0.76 (95% CI, 0.44-0.98), respectively; LV-GCS: 0.80 (95% CI, 0.50-0.96) and 0.75 (95% CI, 0.41-0.98), respectively; LV-GLS: 0.72 (95% CI, 0.40-0.93) and 0.76 (95% CI, 0.48-0.97), respectively. In addition, age, sex, body mass index (BMI), and presence of hypertension or coronary artery disease (CAD) made no impacts on the association between the global strain parameters and the incidence of HF.ConclusionLV-GRS, LV-GCS, and LV-GLS is significantly related to new-onset HF in patients with diabetes at 5 and 10 years.
Higher odds of periodontitis in systemic lupus erythematosus compared to controls and rheumatoid arthritis: a systematic review, meta-analysis and network meta-analysis
Authors: Tan Ping Ren , Lee Aaron J. L. , Zhao Joseph J. , Chan Yiong Huak , Fu Jia Hui , Ma Margaret , Tay Sen Hee 
Published: April 2024

IntroductionPeriodontitis as a comorbidity in systemic lupus erythematosus (SLE) is still not well recognized in the dental and rheumatology communities. A meta-analysis and network meta-analysis were thus performed to compare the (i) prevalence of periodontitis in SLE patients compared to those with rheumatoid arthritis (RA) and (ii) odds of developing periodontitis in controls, RA, and SLE.MethodsPooled prevalence of and odds ratio (OR) for periodontitis were compared using meta-analysis and network meta-analysis (NMA).ResultsForty-three observational studies involving 7,800 SLE patients, 49,388 RA patients, and 766,323 controls were included in this meta-analysis. The pooled prevalence of periodontitis in SLE patients (67.0%, 95% confidence interval [CI] 57.0-77.0%) was comparable to that of RA (65%, 95% CI 55.0-75.0%) (p&gt;0.05). Compared to controls, patients with SLE (OR=2.64, 95% CI 1.24-5.62, p&lt;0.01) and RA (OR=1.81, 95% CI 1.25-2.64, p&lt;0.01) were more likely to have periodontitis. Indirect comparisons through the NMA demonstrated that the odds of having periodontitis in SLE was 1.49 times higher compared to RA (OR=1.49, 95% CI 1.09-2.05, p&lt;0.05).DiscussionGiven that RA is the autoimmune disease classically associated with periodontal disease, the higher odds of having periodontitis in SLE are striking. These results highlight the importance of addressing the dental health needs of patients with SLE.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/ identifier CRD42021272876.