bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of symptomatic metastatic cancer to the liver from primary colon and rectal cancer by the intraarterial administration of chemotherapy and radioactive isotopes
Authors: Ariel Irving M. , Padula Guido 
Published: February 2007

AbstractSixty‐five patients were referred for treatment with symptoms resulting from metastatic cancer to the liver from the GI tract. Two groups of patients were analyzed. The first group of 40 patients were subjected to a laparotomy and insertion of a catheter into the hepatic artery and a second group had the catheter inserted percutaneously and a bolus of cancer chemotherapeutic agents injected into the catheter. In both groups, chemotherapy in the form of 5‐fluorouracil was supplemented by internal irradiaton delivered from the intraarterial administration of Yttrium 90 microspheres. Forty percent of the patients who had an indwelling catheter performed at celiotomy manifested an objective response and in 60% a significant subjective improvement occurred. In the 25 patients whose catheter was inserted percutaneously, the response rate was roughly similar, in that 35% demonstrated an objective response and 65% demonstrated a subjective response.
Urinary etiocholanolone and prognosis in early carcinoma of the breast
Authors: Prescott R. J. , Miller W. R. , Hamilton T. 
Published: February 2007

AbstractEtiocholanolone levels have been measured in both premastectomy and postoperative urines from 86 women with early breast cancer. Levels did not differ between patients subsequently surviving five years following mastectomy and those dying from recurrent disease within this period.
Splenic cysts
Authors: Doolas Alexander , Nolte Minerva , McDonald Owen G. , Economou Steven G. 
Published: February 2007

AbstractBenign non‐parasitic cysts of the spleen are very uncommon, with a total of 651 cases having been described in the literature to date. Because of their uncommon nature, and the fact that their symtoms may be vague, a high index of suspicion is necessary if they are to be diagnosed. The therapy of choice is surgical excision by splenectomy and the accompanying cystectomy. The prognosis following such therapy is excellent.
Hemangiopericytoma of the uterus: Report of a case with a comprehensive review of the literature
Authors: Sooriyaarachchi Gamini S. , Ramirez Guillermo , Roley Everett L. 
Published: February 2007

AbstractA case of locally recurrent and metastatic uterine hemangiopericytoma successfully treated with surgery, radiotherapy and chemotherapy is presented. The patient is alive without evidence of detectable tumor, 13 years after the initial diagnosis. Review of the literature revealed 64 reported cases of uterine hemangiopericytoma. The clinical features are not sufficiently characteristic to enable the diagnosis to be made preoperatively. However, with the help of histological and ultrastructural studies a definite diagnosis of hemangiopericy toma can be made. The primary treatment is radical surgery which usually involves total hysterectomy and bilateral salpingo‐oophorectomy. The prognosis of uterine hemangiopericy toma is better than that of other sites. However, long follow‐up of these patients is necessary because of the tendency to local and distant recurrence many years after the initial treatment. The recurrent tumor should be treated aggressively with surgery, radiotherapy, and chemotherapy as long‐term survival is not unusual.
Combination therapy with mitomycin C, 5‐fluorouracil, and cytosine arabinoside for nonresectable malignant tumor in man
Authors: Yamaguchi Takayuki , Nakamura Masanori 
Published: February 2007

AbstractThe effectiveness of MFC (mitomycin C, 5‐fluorouracil and cytosine arabinoside) therapy for non‐resectable cancers and cancers recurring after surgery was investigated in 60 patients with solid cancers aged 26 to 69 years. Treatment was effective in 28 patients (47%) including seven (12%) who showed a very good response. Side effects included anorexia, vomiting, melena, anemia, decreased leukocyte and platelet counts, and impaired renal function. In particular, hemorrhage of the digestive tract should be watched carefully during MFC therapy. MFC therapy is suitable for solid tumors of the breast and digestive organs, especially with metastases to the lymph nodes. Response to treatment is generally seen after 6–10 doses. If there is no response at this time, treatment should be changed. In cases where induction of remission is successful, maintenance therapy should be continued keeping the frequency of administration to a minimum. Remission is readily induced with MFC therapy, but because of the problems of hemorrhage of the digestive tract, and bone marrow suppression, its use for out patient treatment is not considered safe. Therefore, alternative treatment should be given for long term maintenance of remission. FAMT (5‐fluorouracil, cyclophosphamide‐endoxan, mitomycin C, chromomycin A3‐toyomycin) therapy is considered safe and suitable for maintenance therapy in outpatients. Three cases in which MFC therapy was very effective are described to illustrate the treatment program.
BCG immunotherapy: Effects of dose and route of administration on survival of mice bearing established tumors
Authors: Codish Stephen D. , Monaco Anthony P. 
Published: February 2007

AbstractBacillus Calmette‐Guérin (BCG) was administered in various doses by four different routes to C3H/HeJ mice bearing well‐established syngeneic MC‐42 fibrosarcomas. Injections of BCG into established primary tumors decreased survival of tumor‐bearing mice as compared to saline‐injected controls. Of the three dosage groups, high‐dose (108 viable organisms) intralesional BCG was most detrimental. The injection of low‐dose BCG (104 organisms) into established tumors or subcutaneously at a distant site also shortened host survival times. Other subcutaneous injections and injections of BCG into the peritoneal or pleural cavities had no significant effect on survival, regardless of dosage. The dose‐dependent effects of BCG immunotherapy which may prolong or shorten survival are discussed.
Myxedema coma and inappropriate antidiuretic hormone secretion after deep neck irradiation: Clinical implications and report of a case
Authors: Formeister Joseph F. , Sako Kumao , Razack Mohamed S. , Aungst C. William 
Published: February 2007

AbstractA case report is presented in which myxedema coma and inappropriate antidiuretic hormone secretion developed as a result of radiation therapy and surgery to the neck area in a patient with recurrent metastatic squamous cell carcinoma of the floor of the mouth. Laboratory findings of low thyroxine level and the findings of persistent hyponatremia and hypoosmolality of serum in spite of persistent sodium loss in the urine were helpful in diagnosing the problem. Treatment included thyroid hormone replacement and fluid restriction resulting in complete reversal of her condition.We believe that patients with head and neck cancer who have undergone a course of radiation to the neck, and particularly when thyroid function might have been altered by previous subtotal thyroidectomy as part of a curative resection, should be carefully followed with periodic thyroid function assays and serum electrolytes with particular attention to serum sodium values.
Primary malignant hemangioendothelioma of the liver: Survival following nonoperative treatment
Authors: Langley Jack R. , Rosato Francis E. , El‐Mahdi Anas 
Published: February 2007

AbstractA case of primary hemangioendothelioma is presented. Following autodearterialization, the patient received 5‐fluorouracil orally and total hepatic radiation. To date, 30 months later, he remains alive and active with residual hepatic defect on liver scan, but no indication of progression of disease. Primary malignant hemangioendothelioma is discussed briefly in terms of etiology, pathology, diagnosis, and treatment, and a treatment plan is presented. This case also presented an unusual side effect of 5‐fluorouracil therapy ‐ mononeuritis multiplex ‐ and is presented out of interest.
The value of preoperative screening procedures in stage I and II malignant melanoma
Authors: Aranha Gerard V. , Simmons Richard L. , Gunnarsson Audolfur , Grace Theodor B. , McKhann Charles F. 
Published: February 2007

AbstractFifty patients with melanoma (30 with clinical Stage I disease and 20 with clinical Stage II disease) were analyzed retrospectively along with the screening test done prior to surgery. While the value of the chest X ray is unquestioned in preoperative screening, the same cannot be said of liver, brain, and bone scans. The bone marrow biopsy, however, done with a Janshidi needle was of value in detecting one patient with bone‐marrow metastases who on examination had clinical Stage II disease and precluded surgery in this same individual. Therefore, we feel that in the preoperative scanning of patients with Stage I or Stage II human malignant melanoma, and especially in the latter, the bone‐marrow biopsy should be done routinely in addition to a hematological profile, liver profile, and chest X ray.
Carcinoma of the bronchus with atypical presentation: Report of a case
Authors: Schachner Elbio R. , Schwarz Armin , Freund Uri , Atlan Henry , Durst Arie L. 
Published: February 2007

AbstractA 64‐year‐old man presented with dysphagia due to obstruction of lower third of the esophagus. Esophagoscopy showed narrowing of the esophagus with normal mucosa. Chest X rays were normal, but on lung scan there was no perfusion of the left lung. That patient died of aspiration and on post mortem a carcinoma of the bronchus with abscess formation and perforation into the esophagus was found.
The effect of age and postsplenectomy interval on the susceptibility of the asplenic adult rat to pneumococcal challenge
Authors: Goldthorn Jane F. , Schwartz Allen D. 
Published: February 2007

AbstractThe response to intravenous challenge with pneumococcus was examined in asplenic and sham‐operated adult Sprague‐Dawley rats eighteen weeks following surgery. The LD50 was over 2,000‐fold greater in the sham‐operated animals than in the asplenic animals. These results suggest that the age of an asplenic host, the length of time following splenectomy, and the presence of a normal immune system other than the asplenic state do not in themselves confer immunity.
The relationship between slgM positive lymph‐node lymphocytes and breast cancer metastasis
Authors: Richters Arnis , Paller Mimi 
Published: February 2007

AbstractThe relative frequency of lymphocytes with surface immunoglobulins (sIgM, sIgG, sIgA) was studied in breast‐cancer patients' axillary lymph nodes by the immunofluorescence technique. The study encompassed a total of 105 patients, most of whom had infiltrating ductal carcinoma (IDC). The results have indicated a significantly higher ( p < 0.005) average percentage of sIgM positive lymphocytes in lymph nodes in the group of IDC patients with lymph‐node metastasis. Shortterm followup was available for a limited number of patients, but no conclusions were reached with respect to sIgM positive lymphocytes. It is suggested that evaluation of axillary lymph‐node and peripheral blood lymphocyte subpopulations for each cancer patient would provide new information which could aid in determining the extent of the disease process. Moreover, such information may be of assistance in decisions of therapeutic modalities, detection of occult metastasis, and prediction of prognosis.
Immunologic features of a carcinogen‐induced murine bladder cancer: In vivo and in vitro studies
Authors: Javadpour N. , Hyatt C. L. , Soares T. 
Published: February 2007

AbstractCertain in vivo and in vitro immunologic features of carcinogen‐induced murine bladder cancer have been studied. The consistency of tumor induction, its natural history, and immunogenicity both in vivo and in vitro render this syngeneic murine bladder tumor a suitable model for immunologic studies. Pre‐immunization of strain C3H/Hen mice with mid‐gestational fetal cells did not protect the animals from tumor challenge. Sera of mice immunized with mid‐gestational fetal cells were not cytotoxic to cultured tumor cells in a microcytotoxicity assay indicative of dissimilarity between the tumor associated antigen and the syngeneic mid‐gestational fetal antigen.
Tumoricidal effects of mycobacterium ulcerans toxin on murine adenocarcinoma (C3HBA)
Authors: Heggers John P. , Robson Martin C. , Yetter Joseph F. , Kreig Richard E. , Jennings Paul B. 
Published: February 2007

AbstractFresh homogenized mammary gland adenocarcinoma (C3HBA) material was subcutaneously inoculated in the anterior right thigh of transplant host mice (C3H/HeJ). When tumors were palpable, the mice were separated into three groups. The test group received biweekly intratumoral injections of Mycobacterium ulcerans filtrate containing 40 mg of protein per ml. One control group received intratumoral injections of normal physiological saline, and the remaining group received no treatment at all. The survival rate of toxin‐treated animals was 13.5% at 15 weeks when compared with the control groups. Additionally, tumor metastasis was apparently abrogated in test animals when compared to the control animals. Marked necrosis of the tumors in the test animals was noted by histological examination. Controls showed slight to moderate degrees of tumor necrosis. In this model Mycobacterium ulcerans toxin appears to have therapeutic value as an antitumor agent.
Assessment of myelotoxic effects of chemotherapy from early leukopenic response: Application of a mathematical model for granulopoiesis
Authors: Blumenson Leslie E. , Bross Irwin D. 
Published: February 2007

AbstractA recently developed model of the human granulopoietic system had been used to analyze the toxic effects of 5‐fluorouracil administered to cancer patients. From this analysis there appeared to be a relationship between the level of the early leukopenic depression and the rate at which the drug kills cells in the marrow. In particular, it may be possible to estimate this kill rate from the extent of the maximal depression in the white blood count during the second or third week after treatment begins. This estimate may be useful when planning modifications in treatment in order to prevent the onset of hematologic crises.
Squamous‐cell carcinoma of the pilonidal sinus: Report of a case and review of the literature
Authors: Lerner Harvey J. , Deitrick George 
Published: February 2007

AbstractSquamous‐cell cancer developing in chronic pilonidal sinuses is extremely rare. Thousands of pilonidal cysts and sinuses are operated upon each year, and malignancy is almost never encountered. Only 26 cases of malignancy arising in pilonidal sinuses are reported in the world literature. We report and document a squamous‐cell cancer arising in a chronic pilonidal sinus and also review the world literature.
Electrocoagulation: Palliative surgery to control metastatic cutaneous malignancy
Authors: Reinhold Randolph B. , Lokich Jacob J. 
Published: February 2007

AbstractThe adaptation of the principles of electrocoagulation to controlling symptomatic cutaneous metastatic disease is discussed. The technique permits minimal anesthesia, excellent hemostasis, local control, satisfactory cosmesis with reduced hospitalization. Two illustrative cases are reported of metastatic malignant melanoma and metastatic leiomyosarcoma.
The effect of anticancer therapy on peripheral blood T and B lymphocyte counts and function
Authors: Hadfield T. L. , Marcus S. , Smart C. R. 
Published: February 2007

AbstractPatients categorized according to tumor type were compared to a control nontumor population. Comparison of relative T cell values among the groups showed no significant differences; however, when absolute numbers of T cells/ mm3 were compared, all cancer patients, whether from treated or untreated groups, had significantly depressed T cell values. No significant differences were observed in the relative or absolute numbers of B cells. Comparison of the total lymphocyte response to PHA showed no significant differences among the various cancer groups; however, response in all cancer groups whether from treated or untreated patients, was depressed by comparison to the control group. Patients categorized according to the type of treatment received showed significant depression in the white blood cell count, lymphocyte count, relative and absolute T cell counts and the absolute B cell count in the postsurgery, postadjunctive therapy group. The pretherapy group also showed significant depression in the absolute number of T cells/mm3 when compared to the controls. Response to PHA correlated with the absolute T cell values.
Spontaneous retroperitoneal hemorrhage from a ruptured hypernephroma
Authors: Trivedi R. , Levy M. , Ibrahim I. , Bonacarti A. 
Published: February 2007

AbstractThe clinical presentation and roentgenographic findings of renal cell carcinoma have been consistently variable. These patients can appear with flank pain mimicking ureteral colic, flank tumors, or symptomatic metastasis [1]. Systemic cardiac manifestations including cardiomegaly with congestive heart failure due to arteriovenous fistula formation have been reported [2]. Roentgenographic findings may show the tumor to be either vascular or avascular. It may present as a spontaneous perforation of the pelvic ureteral system which is demonstrated by intravenous pyelography [3]. In this article, we describe a case of hypernephroma in a cyst wall causing severe spontaneous hemorrhage in the retroperitoneal space resulting in a state of hypovolemic shock.
Extraosseous osteogenic sarcoma: Case report
Authors: Lopez R. , Karakousis C. P. , Rao U. , Berjian R. A. , Bakamjian V. 
Published: February 2007

AbstractExtraosseous osteogenic sarcoma is a highly malignant tumor, and in order to improve the chances of survival of those who have it, aggressive surgical treatment, including major amputations, should be performed. Based on the results obtained in the treatment of its osseous counterpart, the use of adjuvant chemotherapy is strongly recommended. Evaluation should not be done because it is usually followed by local recurrence.
Arsenically associated cutaneous squamous cell carcinoma with hypercalcemia
Authors: Southwick Graeme J. , Schwartz Robert Allen 
Published: February 2007

AbstractSquamous cell carcinoma of the skin complicated by hypercalcemia is very rare. This report is of a patient with long‐term exposure to medicinal oral arsenic who developed an extensive squamous cell carcinoma complicated by hypercalcemia.
Management of multiple lung metastases
Authors: Takita Hiroshi , Edgerton Francis , Merrin Claude , Douglass Harold D. , Karakousis Constantine 
Published: February 2007

AbstractDuring the past seven years, 78 patients with multiple lung metastases underwent lung resection. Most of the patients with bilateral lung metastases had lung resection through a median sternotomy rather than by bilateral thoracotomies. “Local excision” of the lung lesions was the most frequently used technique in order to preserve as much lung tissue as possible. Sixty‐three of the 78 patients received adjuvant therapies following lung resection. Operative mortality was 3.8%. The over‐all median survival was 18.3 months. Analysis of the data showed shorter tumor doubling time to be an indicator of poor prognosis, whereas other factors such as disease‐free intervals and unilateral vs bilateral metastases did not affect the postoperative survival.
Immunotherapy of a murine sarcoma using specific antitumor immune RNA
Authors: Webster D. J. T. , Cornacoff J. B. , Vallera D. A. , Dalmasso J. P. , Dodd M. C. , Minton J. P. 
Published: February 2007

AbstractThe effect of IRNA therapy in a polyoma‐induced fibrosarcoma of C3H mice has been studied. Although a protocol that transferred in vitro cytotoxicity was used, no reduction in incidence of tumors, tumor size, or survival was demonstrated. In one experiment, enhancement of tumor growth occurred. It is concluded that cytotoxicity does not reflect in vivo changes and that therapeutic trials of IRNA are premature.
5‐FU versus combination therapy with tubercidin, streptozotocin, and 5‐Fu in the treatment of pancreatic carcinomas: COG protocol 7230
Authors: Awrich Alan , Fletcher William S. , Klotz Jerome H. , Minton John P. , Hill George J. , Aust J. Bradley , Grage Theodor B. , Multhauf Phyllis M. 
Published: February 2007

AbstractFrom May 1972 until May 1976, 105 patients were entered on Central Oncology Group protocol 7230 to compare the combination of streptozotocin, tubercidin, and 5‐fluorouracil (5‐FU) versus 5‐FU alone in the treatment of adenocarcinoma and islet cell carcinoma of the pancreas. Twenty‐nine were not evaluable. Thirty‐six evaluable cases received 5‐FU, and 40 received the combination, with no significant difference in time to progression or survival. Toxicity in the two regimens was somewhat different but was essentially similar in magnitude. Results indicate no benefit in the treatment of adenocarcinoma of the pancreas with the three‐drug combination over 5‐FU alone. All of the islet cell tumor patients benefited from the combination by response or arrest of progression of disease. Further study should be directed toward the use of this combination in the treatment of functioning and non‐functioning islet cell tumors of the pancreas.
Effect of immunochemotherapy on lymphocyte response of patients with gastrointestinal cancer
Authors: Mashiba Harukazu , Yoshinaga Hirokuni , Matsunaga Keiko , Gojobori Mariko , Furusawa Motonosuke 
Published: February 2007

AbstractPatients with gastrointestinal cancer were treated with 5‐fluorouracil (5‐FU) in combination with a streptococcal preparation, OK‐432, or without OK‐432 before operation, and lymphocyte response to PHA was examined. Oral administration of 5‐FU with or without intramuscular injection of OK‐432 did not affect the response. However, treatment with cytostatic drugs in combination with OK‐432 markedly augmented the lymphocyte response to PHA, but the cytotoxic activity of lymphocytes was not elevated.
Epidemiologic aspects of american kaposi's sarcoma
Authors: Laor Yona , Schwartz Robert Allen 
Published: February 2007

AbstractIn our series of 37 patients with Kaposi's sarcoma, a larger than expected incidence of Americans of Italian and Jewish lineage was found, with 51% of Italian and 38% of Jewish background. Although a predominance of these two groups has been clearly shown previously, this may be the highest percentage of any series. In addition, 12, or 32%, of the patients were found to have concurrent diabetes mellitus. This association has been observed previously, but is not generally appreciated.
Further studies on the prognostic importance of barr body frequency in human breast cancer: With discussion on its probable mechanism
Authors: Borah Vidya , Shah P. N. , Ghosh S. N. , Sampat M. B. , Jussawalla D. J. 
Published: February 2007

AbstractBased on the Barr body frequency, a total of 285 unselected breast cancer tissues were categorised as negative and positive tumours; incidence of these two groups in our series was 2:1, respectively. When 2‐years' disease‐free interval and 10‐years' survival were considered, it was seen that patients harbouring negative tumours had significantly early recurrence and shorter duration of survival as compared to those having positive tumours. As vascular spread is the prerequisite of early recurrence, the shorter survival in the patients having negative tumours could be explained on the basis of blood vessel invasion, in that 73% of the negative tumours had blood vessel invasion, in contrast to only 24% in the positive tumours.