bluuebunny/crossref_metadata_2025_split huggingface dataset:
18F-FDG PET/CT versus bone marrow biopsy in detecting bone marrow infiltration in initial staging of pediatric lymphoma
Authors: Bashank Nahla , Sharef Seham , Mohran Taha Zaki , Khalil Maha 
Published: April 2024

Abstract
Background
To evaluate the efficacy of PET/CT using18F-FDG (18F-fluorodeoxyglucose) as a radiotracer compared to conventional bone marrow biopsy (BMB) in detecting infiltration to bone marrow (BM) in pediatric patients with lymphoma at the time of initial diagnosis.

Methods
66 pediatric patients with lymphoma (47Hodgkin’s and 19non-Hodgkin’s lymphoma) were referred for initial staging by18F-FDG PET/CT study. All patients underwent bilateral iliac BMB and 18F-FDG PET/CT scan with no more than 2 weeks interval in-between. Follow-up for at least 6 months was used as a reference standard to compare diagnostic performance between two modalities in detecting bone marrow infiltration (BMI).

Results
Sensitivity, specificity, accuracy, as well as positive and negative predictive values of 18F-FDG PET/CT in detecting BMI were (80%, 86%, 85%, 63%, and 94%) in contrast to BMB (80%, 53%, 59%, 33%, and 90%) respectively. 18F-FDG PET/CT was concordant to BMB in 39/66 patients (59%).

Conclusion
18F-FDG PET/CT was more accurate and specific, with higher predictive values than BMB in detecting BMI during initial staging of pediatric lymphoma. In most pediatric lymphoma patients, 18F-FDG PET/CT can be used instead of BMB to determine BMI during their initial staging process.
Surgically repaired tetralogy of Fallot in the 7th decade: a late presentation of severe pulmonic regurgitation
Authors: Varkoly Kyle , Parekh Akarsh , Ianitelli Melissa , Hamada Mostafa , Lucas Alexandra , Forbes Thomas 
Published: April 2024

Abstract
Background
Surgically repaired tetralogy of Fallot (TOF) is a congenital heart disease with a cumulative survival rate of 72% in the 4th decade of life in longitudinal single-cohort studies. Debate surrounds conservative versus surgical management in adults with TOF once pulmonary regurgitation occurs.

Case presentation
A 73-year-old male with surgically corrected TOF presented with heart failure symptoms. He underwent ToF repair with a classic right Blalock–Taussig shunt at 2 years of age with transannular patching at 18 years of age. Echocardiography revealed elevated right ventricular systolic pressures, severe right ventricular dilatation, and pulmonary regurgitation. Our patient’s new-onset right-sided heart failure was managed medically with diuresis. He received a new pulmonic valve via percutaneous approach on a later planned hospitalization with resolution of symptoms and improved tricuspid regurgitation.

Conclusion
It is a class I recommendation for pulmonic valve intervention once greater than moderate PR occurs; however, medical optimization should take place first. Following adequate RV load optimization, our patient underwent successful transcatheter pulmonic valve implantation with resolution of symptoms and cessation of diuretic.
Cost–utility analysis of using high-intensity statin among post-hospitalized acute coronary syndrome patients
Authors: Dewi Pramitha Esha Nirmala , Thavorncharoensap Montarat , Rahajeng Bangunawati 
Published: April 2024

Abstract
Background
Post-hospitalized acute coronary syndrome (ACS) patients in Indonesia National Insurance does not pay for the use of high-intensity statin (HIS) for secondary prevention after ACS hospitalization. Moreover, a cost–utility analysis needs to be conducted to evaluate the cost-effectiveness of prescribing HIS and low-to-moderate-intensity statin (LMIS) per quality-adjusted life year (QALY). This study aimed to estimate the cost–utility of long-term HIS treatment in post-hospitalized ACS patients in Indonesia compared to current practice.

Results
This study compared the economic outcomes of long-term HIS and LMIS in Indonesian post-hospitalized ACS patients. A lifetime Markov model predicted ACS-related events, costs, and QALY from a payer perspective. A systematic review estimated treatment-specific event probabilities, post-event survival, health-related quality of life, and Indonesia medical-care expenses from published sources. This study conducted probabilistic sensitivity analysis (PSA) using 1000 independent Monte Carlo simulations and a series of one-way deterministic sensitivity analyses utilizing a tornado diagram. The economic evaluation model proved that intensive HIS treatment can increase per-patient QALYs and care expenditures compared to LMIS. The use of HIS among post-hospitalized ACS patients had ICER 31.843.492 IDR per QALY gained, below the Indonesia willingness-to-pay (WTP) for terminal disease and life-saving treatment.

Conclusion
From the Indonesia payer perspective, using HIS for post-hospitalized ACS patients in Indonesia is cost-effective at 31.843.492 IDR per QALY gained.
Portable optical spectroscopy and machine learning techniques for quantification of the biochemical content of raw food materials
Authors: Ricci Cosimo , Gadaleta Agata , Gerardino Annamaria , Didonna Angelo , Ferrara Giuseppe , Bertani Francesca Romana 
Published: April 2024

Abstract

Background

Accuracy in determining food authenticity, possible contamination, content analysis, and even geographical origin is of considerable scientific and economic value. The aim of this study is to facilitate quantitative evaluation of protein content in the seeds of cereals (
Triticum turgidum
var. durum and
Tritordeum
genotypes) and ripening pomegranate fruits (Wonderful cultivar).

Methods

Two species of wheat were evaluated in this study: durum wheat,
Triticum turgidum
var.
durum
, and
Tritordeum (
durum wheat × wild barley
)
together with pomegranate fruits of the variety Wonderful. Two different portable Near InfraRed (NIR) spectrometers have been used: a prototype developed in the PhasmaFood project and the commercial SCiO™ molecular sensor.

Results

Considering the specific samples, the obtained results of the classification models indicate a validation mean absolute error of 0.8% (percentage of total protein content in dry matter) for two species of wheat using Convolutional Neural Network following normalization procedures and 0.32% using Partial Least Square (PLS) analysis applied to
Tritordeum
samples; visible reflectance spectra have been used to discriminate the two cereal species. A Root Mean Square Error (RMSE) of 1.25 was obtained for the determination of total soluble solids (TSS) over a 2-year period for pomegranate fresh fruits of Wonderful cultivar, which is commonly harvested with TSS values of 16–17.

Conclusions
The application of portable sensors using NIR spectroscopy can be a valid and rapid alternative to the use of destructive laboratory techniques for the assessment of protein content in intact wheat seeds and ripeness grade (TSS) in intact pomegranates.
Laxative use in adults with intellectual disabilities: development of prescribing guidelines
Authors: Bishop Ruth , Laugharne Richard , Burrows Lisa ,   CHAMPS Team, Ward Sandra , Eustice Sharon , Branford David , Wilcock Mike , Lamb Kirsten , Tavare Alison , Annesley Charlotte , Lewis Stephen , Voulgaropoulos Vasileios , Sleeman Faye , Sargent Beth , Shankar Rohit 
Published: April 2024

BackgroundConstipation is overrepresented in people with intellectual disabilities. Around 40% of people with intellectual disabilities who died prematurely were prescribed laxatives. A quarter of people with intellectual disabilities are said to be on laxatives. There are concerns that prescribing is not always effective and appropriate. There are currently no prescribing guidelines specific to this population.AimsTo develop guidelines to support clinicians with their decision-making when prescribing laxatives to people with intellectual disabilities.MethodA modified Delphi methodology, the RAND/UCLA Appropriateness Method, was used. Step 1 comprised development of a bespoke six-item, open-ended questionnaire from background literature and its external validation. Relevant stakeholders, including a range of clinical experts and experts by experience covering the full range of intellectual disability and constipation, were invited to participate in an expert panel. Panel members completed the questionnaire. Responses were divided into ‘negative consensus’ and ‘positive consensus’. Members were then invited to two panel meetings, 2 weeks apart, held virtually over Microsoft Teams, to build consensus. The expert-by-experience group were included in a separate face-to-face meeting.ResultsA total of 20 people (ten professional experts and ten experts by experience, of whom seven had intellectual disability) took part. There were five main areas of discussion to reach a consensus i.e. importance of diagnosis, the role of prescribing, practicalities of medication administration, importance of reviewing and monitoring, and communication.ConclusionsLaxative prescribing guidelines were developed by synthesising the knowledge of an expert panel including people with intellectual disabilities with the existing evidence base, to improve patient care.
The Influence of Surgical Complexity and Center Experience on Postoperative Morbidity After Minimally Invasive Surgery in Gynecologic Oncology: Lessons Learned from the ROBOGYN-1004 Trial
Authors: Lambaudie Eric , Bogart Emilie , Le Deley Marie-Cécile , EL Hajj Houssein , Gauthier Tristan , Hebert Thomas , Collinet Pierre , Classe Jean Marc , Lecuru Fabrice , Motton Stephanie , Conri Vanessa , Ferrer Catherine , Marchal Frederic , Ferron Gwenael , Probst Alicia , Jauffret Camille , Narducci Fabrice 
Published: April 2024

Abstract
Background
This study was a secondary analysis of the ROBOGYN-1004 trial conducted between 2010 and 2015. The study aimed to identify factors that affect postoperative morbidity after either robot-assisted laparoscopy (RL) or conventional laparoscopy (CL) in gynecologic oncology.

Methods
The study used two-level logistic regression analyses to evaluate the prognostic and predictive value of patient, surgery, and center characteristics in predicting severe postoperative morbidity 6 months after surgery.

Results
This analysis included 368 patients. Severe morbidity occurred in 49 (28 %) of 176 patients who underwent RL versus 41 (21 %) of 192 patients who underwent CL (p = 0.15). In the multivariate analysis, after adjustment for the treatment group (RL vs CL), the risk of severe morbidity increased significantly for patients who had poorer performance status, with an odds ratio (OR) of 1.62 for the 1-point difference in the WHO performance score (95 % CI 1.06–2.47; p = 0.027) and according to the type of surgery (p < 0.001). A focus on complex surgical acts showed significant more morbidity in the RL group than in the CL group at the less experienced centers (OR, 3.31; 95 % CI 1.0–11; p = 0.05) compared with no impact at the experienced centers (OR, 0.87; 95 % CI 0.38–1.99; p = 0.75).

Conclusion
The findings suggest that the center’s experience may have an impact on the risk of morbidity for patients undergoing complex robot-assisted surgical procedures.
Prevalence of hepatitis B virus infection and its associated factors among students in N’Djamena, Chad
Authors: Debsikréo Nalda , Mankréo Birwé Léon , Moukénet Azoukalné , Ouangkake Merwa , Mara Nathan , Moussa Ali Mahamat , Toure-Kane Ndèye Coumba , Lunel-Fabiani Françoise 
Published: April 2024

Introduction
Infection by hepatitis B virus (HBV) is a major issue in public health. The prevalence of HBV in Chad is 12.4%, all age groups considered. Here, we aimed to determine the prevalence of HBV and its associated factors among university students in N’Djamena, the country’s capital.

Methods
A cross-sectional survey of students at either the University of N’djamena or Emi Koussi University was conducted from 3 to 23 July 2021. All participating students provided signed, informed consent and were included in the study consecutively. Blood samples were collected, and serum tested for hepatitis B surface antigen (HBsAg) using the Determine HBsAg rapid test kit, with confirmation of positive tests on an Abbott Architect i1000SR analyzer. Descriptive analysis and logistic regression were used to determine associations between the outcome variable and independent/covariate variables.

Results
A total of 457 students with a median age of 24 years were included across different faculties. The prevalence of HBV infection was 14.87% (68/457). Most students (75%) were aged 25 years or less. Unprotected sex was reported by 64.9% of the students and multiple sexual partners by 53.6%. Furthermore, 45.7% of them reported having no knowledge of hepatitis B. Having an HBsAg-positive mother (AOR: 2.11), having a history of transcutaneous medical procedures (AOR: 2.97) and living with a family (AOR: 4.63) were significantly associated with HBV status. Age ≥26 years appeared as a protective factor (AOR = 0.41).

Conclusion
Our study detected a high, 14.87% prevalence of HBV infection among students in N’djamena, Chad, and shed light on its associated factors. HBV prevention strategies should include raising awareness among students, making full hepatitis vaccination mandatory before children begin school, promoting mass screening to identify and treat chronic HBV carriers and reduce transmission, and reducing the cost of vaccination.
Integration of single-cell RNA-seq and bulk RNA-seq to construct liver hepatocellular carcinoma stem cell signatures to explore their impact on patient prognosis and treatment
Authors: Liu Lixia , Zhang Meng , Cui Naipeng , Liu Wenwen , Di Guixin , Wang Yanan , Xi Xin , Li Hao , Shen Zhou , Gu Miaomiao , Wang Zichao , Jiang Shan , Liu Bin 
Published: April 2024

Background
Liver hepatocellular carcinoma (LIHC) is a prevalent form of primary liver cancer. Research has demonstrated the contribution of tumor stem cells in facilitating tumor recurrence, metastasis, and treatment resistance. Despite this, there remains a lack of established cancer stem cells (CSCs)-associated genes signatures for effectively predicting the prognosis and guiding the treatment strategies for patients diagnosed with LIHC.

Methods
The single-cell RNA sequencing (scRNA-seq) and bulk RNA transcriptome data were obtained based on public datasets and computerized firstly using CytoTRACE package and One Class Linear Regression (OCLR) algorithm to evaluate stemness level, respectively. Then, we explored the association of stemness indicators (CytoTRACE score and stemness index, mRNAsi) with survival outcomes and clinical characteristics by combining clinical information and survival analyses. Subsequently, weighted co-expression network analysis (WGCNA) and Cox were applied to assess mRNAsi-related genes in bulk LIHC data and construct a prognostic model for LIHC patients. Single-sample gene-set enrichment analysis (ssGSEA), Cell-type Identification By Estimating Relative Subsets Of RNA Transcripts (CIBERSORT) and Tumor Immune Estimation Resource (TIMER) analysis were employed for immune infiltration assessment. Finally, the potential immunotherapeutic response was predicted by the Tumor Immune Dysfunction and Exclusion (TIDE), and the tumor mutation burden (TMB). Additionally, pRRophetic package was applied to evaluate the sensitivity of high and low-risk groups to common chemotherapeutic drugs.

Results
A total of four genes (including STIP1, H2AFZ, BRIX1, and TUBB) associated with stemness score (CytoTRACE score and mRNAsi) were identified and constructed a risk model that could predict prognosis in LIHC patients. It was observed that high stemness cells occurred predominantly in the late stages of LIHC and that poor overall survival in LIHC patients was also associated with high mRNAsi scores. In addition, pathway analysis confirmed the biological uniqueness of the two risk groups. Personalized treatment predictions suggest that patients with a low risk benefited more from immunotherapy, while those with a high risk group may be conducive to chemotherapeutic drugs.

Conclusion
The current study developed a novel prognostic risk signature with genes related to CSCs, which provides novel ideas for the diagnosis, prognosis and treatment of LIHC.
Decreased risk of underdosing with continuous infusion versus intermittent administration of cefotaxime in patients with sickle cell disease and acute chest syndrome
Authors: Razazi Keyvan , Berti Enora , Cecchini Jerome , Carteaux Guillaume , Habibi Anoosha , Bartolucci Pablo , Arrestier Romain , Gendreau Ségolène , de Prost Nicolas , Hulin Anne , Dessap Armand Mekontso 
Published: April 2024

Objective
Underdosing of antibiotics is common in patients with sickle cell disease (SCD). We hypothesized that in critically-ill patients with SCD receiving cefotaxime during acute chest syndrome, the continuous infusion may outperform the intermittent administration in achieving pharmacokinetic/pharmacodynamic targets.

Design
Prospective before-after study.

Settings
Intensive-care unit of a French teaching hospital and sickle cell disease referral center.

Patients
Sixty consecutive episodes of severe acute chest syndrome in 58 adult patients with sickle cell disease.

Interventions
Patients were treated with intermittent administration during the first period (April 2016 –April 2018) and with continuous infusion during the second period (May 2018 –August 2019).

Measurements and main results
We included 60 episodes of acute chest syndrome in 58 patients (29 [25–34] years, 37/58 (64%) males). Daily dose of cefotaxime was similar between groups (59 [48–88] vs. 61 [57–64] mg/kg/day, p = 0.84). Most patients (>75%) presented a glomerular hyperfiltration with no difference between groups (p = 0.25). More patients had a cefotaxime trough level ≥2 mg/L with continuous infusion than intermittent administration: 28 (93%) vs. 5 (16%), p<0.001. The median residual concentration was higher in the continuous infusion than intermittent administration group: 10.5 [7.4–13.3] vs. 0 [0–0] mg/L, p<0.001. No infection relapse was observed in the entire cohort. Hospital length of stay was similar between groups.

Conclusion
As compared to intermittent administration, continuous infusion of cefotaxime maximizes the pharmacokinetic/pharmacodynamic parameters in patients with SCD. The clinical outcome did not differ between the two administration methods; however, the study was underpowered to detect such a difference.
LOGISTICS OF EXPORT DELIVERY IN THE CONTEXT OF CROSS-BORDER TRADE
Authors: Bocharov S. N. , Butakova M. M. , Sokolova O. N. 
Published: April 2024

The article is devoted to one of the aspects of the formation of new export logistics, capable of responding to the challenges of a turbulent global economy. The authors analyze modern logistics problems of export supplies. Particular attention is paid to exports as an integral part of cross-border trade. The authors dwell not only on the general problems of logistics of export activities, but also identify the specifics of the logistics of cross-border trade, choosing as the object of study the countries of Greater Altai, which includes the border territories of the Russian Federation, Mongolia, the Republic of Kazakhstan and the People's Republic of China.
The study analyzed the dynamics and structure of exports of the Russian Federation and the Altai Territory, and showed the features of new logistics in a turbulent economy. Given the high share of logistics costs in the overall cost structure of the production and sale of exported products, cross-border trade has advantages when it is carried out with lower logistics costs due to shorter transport routes and transportation times. The advantages of cross-border export include the absence of transit through the territories of third countries, which significantly reduces risks and simplifies information and customs logistics. Stable supply chains in cross-border trade in the Altai Territory, which have emerged as a result of many years of cooperation with the countries of Greater Altai, also help reduce risks and logistics costs.
IMPROVING WORKING CONDITIONS FOR WORKERS INSTALLING MONUMENTS IN RITUAL ECONOMY
Authors: Senchenko V. A. , Kaverzneva T. T. , Fetisov A. G. , Arslanbekova F. F. 
Published: April 2024

The ritual industry in everyday life is emotionally associated with mourning. Оccupational safety issues in this industry are not discussed as widely in society as in other industries. The ritual industry does not have its own sectoral labor protection rules, therefore, labor protection issues are regulated only by intersectoral labor protection rules.
Memorial structures in terms of weight, as a rule, exceed the maximum permissible norms for single lifting and moving weights for men. Therefore, when lifting and moving memorial structures, means of small mechanization are required.
In large cities, burial in cemeteries is very dense and the passages between the graves are getting narrower and narrower. Therefore, at present, an essential requirement for the means of mechanization for the transportation
of monuments is the requirement that the dimensions of transport mechanisms correspond to the dimensions of narrow passages. Various types of mechanization equipment (trolleys) for transporting monuments are presented on the Russian market, but most of them are wider in size than necessary.
This article examines the working conditions and risks of a worker installing monuments in a ritual household. The article presents technical solutions for moving memorial structures around the cemetery using small-scale mechanization tools to reduce the severity of workers» labor. Reducing the severity of workers» work will reduce the number of.
INTEGRATION OF THE ALTAI KRAI AND THE SIBERIAN REGIONS ON COMMODITY MARKETS IN DIFFERENT PERIODS BETWEEN 2001 AND 2022: EXPERIENCE OF COMPARATIVE ANALYSIS. PART 1. 2001-2007
Authors: Trotskovsky A. Ya. , Rodionova L. V. , Nazemtseva Yu. Yu. 
Published: April 2024

This article is а publication devoted to presenting the results of a study of trade and the Altai Krai's economic relations of with the regions of Russia in 1990-2022. The authors are the first to attempt to reveal the dynamics
of changes in the commodity markets of the region for more than twenty years, to assess the role and place of the Siberian regions as consumers of Altai products and suppliers of their products to the Altai market. At the same time, the assessment of the role of the Siberian regions was carried out in two ways: both their total role in the import (export) of products in comparison with other Russian federal districts, and each of the Siberian regions, taking into account their specialization.
A special place in the study was occupied by the analysis of the situation in the food market of the region due to its significance for the region.
Based on the results of the analysis, it was concluded that integration in the commodity markets of the Altai Krai and the Siberian regions as a whole is deeper compared to the other Russian regions. During the period under study, integration further deepened.
The Siberian regions play a significant role both in the consumption of Altai goods, primarily food, and, in particular, in saturating the commodity markets of the region.
The scale and nature of trade and economic relations between the Altai Krai and the Siberian regions are revealed in detail. Characteristic features were variability and inconstancy of the key characteristics of interregional trade and economic relations, coupled with their noticeable inertia, significant differences in trade relations with each of the Siberian regions.