bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parkin inhibits proliferation and migration of bladder cancer via ubiquitinating Catalase
Authors: Zhang Renjie , Jiang Wenyu , Wang Gang , Zhang Yi , Liu Wei , Li Mingxing , Yu Jingtian , Yan Xin , Zhou Fenfang , Du Wenzhi , Qian Kaiyu , Xiao Yu , Liu Tongzu , Ju Lingao , Wang Xinghuan 
Published: February 2024

AbstractPRKN is a key gene involved in mitophagy in Parkinson’s disease. However, recent studies have demonstrated that it also plays a role in the development and metastasis of several types of cancers, both in a mitophagy-dependent and mitophagy-independent manner. Despite this, the potential effects and underlying mechanisms of Parkin on bladder cancer (BLCA) remain unknown. Therefore, in this study, we investigated the expression of Parkin in various BLCA cohorts derived from human. Here we show that PRKN expression was low and that PRKN acts as a tumor suppressor by inhibiting the proliferation and migration of BLCA cells in a mitophagy-independent manner. We further identified Catalase as a binding partner and substrate of Parkin, which is an important antioxidant enzyme that regulates intracellular ROS levels during cancer progression. Our data showed that knockdown of CAT led to increased intracellular ROS levels, which suppressed cell proliferation and migration. Conversely, upregulation of Catalase decreased intracellular ROS levels, promoting cell growth and migration. Importantly, we found that Parkin upregulation partially restored these effects. Moreover, we discovered that USP30, a known Parkin substrate, could deubiquitinate and stabilize Catalase. Overall, our study reveals a novel function of Parkin and identifies a potential therapeutic target in BLCA.
Spatial variability of and effect of light on the cœlenteron pH of a reef coral
Authors: Crovetto Lucas , Venn Alexander A. , Sevilgen Duygu , Tambutté Sylvie , Tambutté Eric 
Published: February 2024

AbstractCoral reefs, the largest bioconstruction on Earth, are formed by calcium carbonate skeletons of corals. Coral skeleton formation commonly referred to as calcification occurs in a specific compartment, the extracellular calcifying medium (ECM), located between the aboral ectoderm and the skeleton. Calcification models often assume a direct link between the surrounding seawater and the ECM. However, the ECM is separated from the seawater by several tissue layers and the cœlenteron, which contains the cœlenteric fluid found in both polyps and cœnosarc (tissue connecting the polyps). Symbiotic dinoflagellate-containing cells line the cœlenteron and their photosynthetic activity contributes to changes in the chemistry of the cœlenteric fluid, particularly with respect to pH. The aim of our study is to compare cœlenteron pH between the cœnosarc and polyps and to compare areas of high or low dinoflagellate density based on tissue coloration. To achieve this, we use liquid ion exchange (LIX) pH microsensors to profile pH in the cœlenteron of polyps and the cœnosarc in different regions of the coral colony in light and darkness. We interpret our results in terms of what light and dark exposure means for proton gradients between the ECM and the coelenteron, and how this could affect calcification.
A push–pull FVF LDO with full‐spectrum PSR and fast transient response
Authors: Zheng Heng , Liu Baixin , Wang Chen , Wang Xukun , Zhou Bo 
Published: February 2024

AbstractA push–pull low‐dropout regulator based on flipped voltage follower is proposed and designed in 65 nm CMOS, which has a push‐current mode and a pull‐current one. The push‐current mode with 1.2‐V input and 1‐V output effectively drives load circuits that are sensitive to supply noise. The pull‐current one with 1.2‐V input and 0.2‐V output effectively drives load circuits that are sensitive to ground noise. Both operating modes feature full‐spectrum power supply rejection (PSR) below −12 dB and achieve 2.4‐ns transient response time over load current (IL) of 10 µA to 20 mA. The presented design achieves a fast transient response and a high‐frequency PSR with a low‐gain fast loop (loop‐I), and enhances the low‐frequency PSR and the line/load regulation with a high‐gain slow loop (loop‐II). Furthermore, the circuit features a load regulation less than 0.09 mV/mA over IL of 10 µA to 20 mA and a line regulation less than 0.01 mV/mV, within a 120‐mV ripple applied to supply/ground. This design consumes a 58‐µA quiescent current (IQ) in both push‐current and pull‐current modes. The low‐dropout regulator works well over the load capacitor (CL) of 0 to 30 pF.
Solving differential‐algebraic equations in power system dynamic analysis with quantum computing
Authors: Tran Huynh T. T. , Nguyen Hieu T. , Vu Long T. , Ojetola Samuel T. 
Published: February 2024

AbstractPower system dynamics are generally modeled by high dimensional non‐linear differential‐algebraic equations (DAEs) given a large number of components forming the network. These DAEs' complexity can grow exponentially due to the increasing penetration of distributed energy resources, whereas their computation time becomes sensitive due to the increasing interconnection of the power grid with other energy systems. This paper demonstrates the use of quantum computing algorithms to solve DAEs for power system dynamic analysis. We leverage a symbolic programming framework to equivalently convert the power system's DAEs into ordinary differential equations (ODEs) using index reduction methods and then encode their data into qubits using amplitude encoding. The system non‐linearity is captured by Hamiltonian simulation with truncated Taylor expansion so that state variables can be updated by a quantum linear equation solver. Our results show that quantum computing can solve the power system's DAEs accurately with a computational complexity polynomial in the logarithm of the system dimension. We also illustrate the use of recent advanced tools in scientific machine learning for implementing complex computing concepts, that is, Taylor expansion, DAEs/ODEs transformation, and quantum computing solver with abstract representation for power engineering applications.
Research Progress of Natural Product Photosensitizers in Photodynamic Therapy
Authors: Zhou Xiaoxia , Ying Xufang , Wu Linjie , Liu Liqin , Wang Ying , He Ying , Han Min 
Published: February 2024

AbstractPhotodynamic therapy is a noninvasive cancer treatment that utilizes photosensitizers to generate reactive oxygen species upon light exposure, leading to tumor cell apoptosis. Although photosensitizers have shown efficacy in clinical practice, they are associated with certain disadvantages, such as a certain degree of toxicity and limited availability. Recent studies have shown that natural product photosensitizers offer promising options due to their low toxicity and potential therapeutic effects. In this review, we provide a summary and evaluation of the current clinical photosensitizers that are commonly used and delve into the anticancer potential of natural product photosensitizers like psoralens, quinonoids, chlorophyll derivatives, curcumin, chrysophanol, doxorubicin, tetracyclines, Leguminosae extracts, and Lonicera japonica extract. The emphasis is on their phototoxicity, pharmacological benefits, and effectiveness against different types of diseases. Novel
and more effective natural product photosensitizers for future clinical application are yet to be explored in further research. In conclusion, natural product photosensitizers have potential in photodynamic therapy and represent a promising area of research for cancer treatment.
Practice Patterns for Managing Recurrent Glioblastoma Multiforme
Authors: Bajaj Jitin , Kedia Shweta , Sharma Arvind , Gupta Pankaj , Ansari Mohammad , Deora Harsh , Garg Kanwaljeet , Dash Chinmaya , Madhugiri Venkatesh S. , Das Kuntal Kanti , Tripathi Manjul , Singh Deepak K. , Raju Subodh , Jagetia Anita , Vazhayil Vikas , Singh Manmohan , Mittal R.S. , Gupta Subhash , Yadav Y.R. , Ramzan Altaf , Umredkar Alok , Jha Deepak Kumar , Mahapatra A.K. 
Published: February 2024

Abstract
Introduction Glioblastoma multiforme (GBM) is a devastating form of cancer with a poor prognosis despite available treatments. Managing recurrent GBM remains challenging and lacks guidelines. This study aims to provide practice patterns for managing recurrent GBMs in India.
Methods A panel of experts was assembled to develop practice patterns using the Delphi technique. Their responses were analyzed anonymously to ensure impartiality and generate recommendations. The statements were intended to be nonbinding and focused on promoting best practices in the field, without legal or regulatory authority.
Results A total of 23 experts participated in the study, providing their opinions on various aspects of managing recurrent GBM. Consensus was achieved on individualized and multidisciplinary management as the preferred approach. Surgery in combination with other treatments was found to impact survival in patients older than 65 years, with re-surgery and adjuvant radiation and chemotherapy being the preferred options. Gadolinium-enhanced magnetic resonance imaging (MRI) brain with spectroscopy and diffusion-weighted imaging was favored. Molecular profiling was considered significant, with O6-methylguanine DNA methyltransferase methylation being most relevant. Surgery was recommended for recurrent GBMs, primarily based on Karnofsky's performance score (KPS). Surgical adjuncts such as neuronavigation and intraoperative MRI were considered valuable. Radiation therapy, specifically stereotactic radiosurgery, was recommended for selected cases, while opinions on re-chemotherapy were divided. Palliative care was deemed important.
Conclusion This study presents practice patterns for managing recurrent GBM in India, providing standardized recommendations for practice. By implementing these, clinicians can make informed decisions, leading to improved patient outcomes and reduced variability in the management of recurrent GBM.
Implantation of a Newly Designed Supratarsal Gold Weight versus the Traditional Pretarsal Model for the Correction of Long-standing Paralytic Lagophthalmos: A Retrospective Cohort Study
Authors: Lailaksiri Natthiya , Wanichsetakul Pawarit , Saonanon Preamjit 
Published: February 2024

Abstract
Background The study determined to compare the clinical outcomes of traditional gold weight implantation for the correction of paralytic lagophthalmos with those of a newly designed model.
Methods In this retrospective cohort study, we enrolled 30 patients (76% females; average age 60.8 ± 12 years) with facial palsy who underwent implantation of either the traditional pretarsal gold weight (PT group; n = 15) or a new supratarsal model (ST group; n = 15) from May 2014 to April 2019. The main outcome measures were the 12-month postoperative weight prominence, weight migration, improvement of lagophthalmos, upper eyelid contour, and upper eyelid ptosis. The secondary outcome was long-term (24 months) reoperative rate.
Results The new model group had significantly better eyelid contour (risk ratio [RR] 3.16, 95% confidence interval [CI] 1.62–6.15, p = 0.001), less weight prominence (RR 1.74, 95% CI 1.13–2.70, p = 0.013), less weight migration (RR 1.31, 95% CI 1.12–1.54, p = 0.001), and less eyelid ptosis (RR 2.36, 95% CI 1.21–4.59, p = 0.011) than the traditional model group. Improvement of lagophthalmos was not statistically significant between the two groups (RR 1.44, 95% CI 0.72–2.91, p = 0.303). The 24-month reoperative rate was 53.3% in the PT group versus 13.3% in the ST group (RR 2.00, 95% CI 1.15–3.49, p = 0.015).
Conclusion The newly designed supratarsal gold weight showed superior postoperative outcomes than the standard traditional model.
Two Uncommon Cases of Pediatric Transethmoidal–Transnasal Encephaloceles with a Review of Literature
Authors: Acharya Abhijit , Senapati Satya Bhusan , Panigrahi Souvagya , Deo Rama Chandra , Mahapatra A. K. 
Published: February 2024

AbstractEncephaloceles are defined as the herniation of brain matter beyond the confines of the skull bone through a defect on the cranium or face. The encephaloceles are classified into different categories as per onset as congenital or traumatic, as per contents as meningocele, meningoencephalocele, and hydromeningoencephalocele, and as per anatomical location into frontoethmoid, basal, occipital, and cranial vault. Transethmoidal encephalocele is a rare type of encephalocele with a very few patients reported in the literature to date. We are presenting two cases of transethmoidal–transnasal encephalocele in the pediatric age group with one being congenital and other traumatic in onset. The first child presented with a mass visible inside the nasal cavity since birth with nasal obstruction. The second child presented with a history of trauma 5 years back followed by occasional cerebrospinal fluid leak, fever, and nasal stuffiness. Both patients underwent craniotomy and excision of the encephalocele with repair of the defect in the cribriform plate. These two uncommon cases highlight the different onsets of the disease successfully managed surgically.
COVID-19-Related Brief Insomnia in a 13-Year-Old Adolescent Girl
Authors: Serdengeçti Nihal , Tarakçıoğlu Mahmut Cem 
Published: February 2024

AbstractNeuropsychiatric manifestations that have developed after coronavirus disease 2019 (COVID-19) infection have not been fully clarified yet. Persistent insomnia and consequent significant impairment in daily functioning is an unexpected symptom of COVID-19 infection. In this case report, a 13-year-old female patient who presented with complaint of insomnia starting with COVID-19 infection is discussed. The patient showed significant improvement with melatonin treatment and maintained her wellbeing in the follow-up. Melatonin may be a useful option to treat COVID-19-related brief insomnia in adolescents. Our case report will be a step forward to help clinicians examine the underlying neurovegetative mechanisms, such as sleep, to improve patients wellbeing. HEADINGS: COVID-19. Melatonin. Sleep Initiation and Maintenance Disorders
Spontaneous Rupture of Superficial Femoral Artery Treated Endovascularly Using CO2 Angiography
Authors: Padhi Rasmiranjan , Dhanasekaran Jagadeesan , P. Vinoth 
Published: February 2024

AbstractSpontaneous rupture of the superficial femoral artery (SFA) is extremely rare. We report an interesting case of an elderly man presented with a history of hearing a click sound in his left lower thigh followed by sudden onset pain, swelling, and discoloration in the left lower limb while coming back from the bathroom. He was a known case of chronic kidney disease, and cirrhosis of the liver with moderate left ventricular (LV) dysfunction. We treated the ruptured SFA using overlapping stent grafts with CO2 angiography. The pseudoaneurysm got thrombosed. The pain and swelling of the left lower limb gradually subsided. The patient went home walking.
Minimizing the Pain of Local Anesthesia Administration in Interventional Radiology with an Anesthetic Portal Technique
Authors: Suttle Dylan , Gill Virpal , Sheeran Daniel , Keefe Nicole , Davis Claire , Patrie James , Angle John F. 
Published: February 2024

Abstract
Objective This article assesses the effectiveness of a standardized local anesthetic (LA) technique designed to minimize the pain of local anesthesia administration in interventional radiology (IR).
Materials and Methods A prospective study compared participants' experience in a control group (n = 63) of random LA administration techniques to a separate experimental group (n = 60) with a standardized technique based on known methods to minimize the pain of LA. Participants in each group were surveyed after LA administration to assess perceived pain and number of times a painful stick was felt. Participants were also asked to compare LA pain to prior experiences with LA, and to compare the overall pain experienced during the procedure to expected pain.
Statistical Analysis Ordinal variable distribution analyses were performed using the Wilcoxon rank sum test. Categorical variable analyses were performed with the Pearson's global exact chi-square test.
Results Pain of LA (mean 1.1 vs. 3.3 on a 0–10 scale, p < 0.001), number of times a painful stick was felt (mean 0.8 vs. 1.9 times, p < 0.001), and overall pain during the procedure (mean 1.5 vs. 3.4 on 0–10 scale, p < 0.001) were significantly less using the standardized versus random techniques. Compared with prior experiences of LA, pain using the standardized technique was less in 77.6%, the same in 22.4%, and more in 0% of patients while pain using the random technique was less in 46.4%, the same in 39.3%, and more in 14.3% of patients (p < 0.05).
Conclusion Severity and frequency of pain from LA administration in IR procedures is minimized using a standardized anesthetic portal technique. This technique may also decrease overall pain experienced during IR procedures as well.
Bystanders’ collective responses set the norm against hate speech
Authors: Zapata Jimena , Sulik Justin , von Wulffen Clemens , Deroy Ophelia 
Published: February 2024

AbstractHate speech incidents often occur in social settings, from public transport to football stadiums. To counteract a prevailing passive attitude towards them, governmental authorities, sociologists, and philosophers stress bystanders’ responsibility to oppose or block hate speech. Here, across two online experiments with UK participants using custom visual vignettes, we provide empirical evidence that bystanders’ expression of opposition can affect how harmful these incidents are perceived, but only as part of a collective response: one expressed by a majority of bystanders present. Experiment 1 (N = 329) shows that the silence or intervention of three bystanders affects the harm caused by hate speech, but one bystander does not. Experiment 2 (N = 269) shows this is not simply a matter of numbers but rather one of norms: only unanimous opposition reduces the public perception of the damage created by the incident. Based on our results, we advance an empirical norm account: group responses to hate speech modulate its harm by indicating either a permissive or a disapproving social norm. Our account and results, showing the need to consider responses to hate speech at a collective level, have direct implications for social psychology, the philosophy of language and public policies.
Applying Q-methodology to investigate computer science teachers’ preferences about students’ skills and knowledge for obtaining a degree
Authors: Takács Rita , Takács Szabolcs , Kárász Judit T. , Oláh Attila , Horváth Zoltán 
Published: February 2024

AbstractStudents’ dropout of Computer Science (CS) education is a crucial issue. This study aims to investigate one of the aspects which can help to retain our students. It is vital to examine CS education on the challenge of competence transition within the BSc curriculum from faculty perspectives. Teachers’ expectations about students’ skills and knowledge are important to understand because they influence learning outcomes and teaching methodologies. Acquiring hard skills and professional skills has outstanding significance in preparing students for their future careers. This study uses Q-methodology to identify the different viewpoints on the skills necessary to obtain a CS degree. Teachers from CS bachelor’s programmes at a large European university participated in the study and shared their opinions. The participants were asked to rank the statements along a spectrum of “the most important skill” to “unimportant skill” (containing hard skills as well as soft skills). Factor analysis revealed five factors that are key components to obtaining a degree in CS: 1. analytical and technical skills, 2. teamwork and self-study experience, 3. group programming experience, 4. communication and problem-solving skills, 5. mathematical foundations and process modelling ability. This exploratory study applied a new research instrument and approach to incorporate teachers’ perspectives into research and practice. These findings could help administrators develop new curricula in order to increase students’ retention. We confirmed the need for acquiring professional skills and highlighted the need for designing new programmes which can improve students’ soft skills to prepare them for work in the IT field.
Workplace cyberbullying and social capital among Jordanian university academic staff: a cross-sectional study
Authors: Alrawashdeh Maissa N. , Alsawalqa Rula Odeh , Alnajdawi Ann , Aljboor Rami , AlTwahya Fawzi , Ibrahim Abdullah Mahmod 
Published: February 2024

AbstractWorkplace cyberbullying has harmful psychological, social, and behavioral consequences for employees and employers. This study investigates workplace cyberbullying among academic staff of both sexes at Jordanian universities, to explore their exposure to workplace cyberbullying by colleagues and employers and its correlation with social capital and self-esteem. Data were collected through an anonymous online survey involving Jordanian academic staff. The findings revealed that workplace cyberbullying reduces with increasing social capital. No relationship was detected between workplace cyberbullying and self-esteem. A positive correlation was found between self-esteem and structural social capital. Age, sex, and university sector do not predict academic workplace cyberbullying levels. The results indicate that administrators and policymakers in the Jordanian higher education sector should improve social capital among academics, given its positive implications for self-esteem, organizational life, and the prevention of distress. This strategy is appropriate in the turbulent conditions confronting academics working in a context with an increasingly dominant digital culture.
Understanding neighborhood income segregation around the clock using mobile phone ambient population data
Authors: Cai Liang , Song Guangwen , Zhang Yanji 
Published: February 2024

AbstractThis study examines the temporal changes in income segregation within the ambient population around the clock using mobile phone big data. It employs ordinal entropy, a metric suited for measuring segregation among ordered groups, to quantify the level of segregation among eight income groups within micro-geographic units throughout the 24-h period on a weekday and a weekend day in the urban core of Guangzhou, China. The study further decomposes daily segregation by location and time profile. We identify urban functions and neighborhood contexts relevant for income segregation and explore their temporal variation. Using group-based trajectory analysis, we classify daily segregation trends among 400 m urban grids into seven distinct trajectories for both weekday and weekend. Our findings confirm that segregation fluctuates constantly. The role of local urban functions, particularly retail, accommodation, and offices, and neighborhood context, such as the number of residents and the share of non-local migrants, exhibits a significant temporal rhythm. The seemingly convoluted 24-h segregation time series among urban grids follow just a few distinct trajectories with clear geographical patterns. There is limited variability at individual grids both over the course of a day and across days. Shifts across different trajectory types between weekday and weekend are rare. The dynamic daily segregation in the ambient population per se may be an enduring characteristic of neighborhoods and a real-time channel for neighborhood contextual influences, potentially fueling long-term residential segregation and neighborhood change.