bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alzheimer's disease heterogeneity revealed by neuroanatomical normative modeling
Authors: Loreto Flavia , Verdi Serena , Kia Seyed Mostafa , Duvnjak Aleksandar , Hakeem Haneen , Fitzgerald Anna , Patel Neva , Lilja Johan , Win Zarni , Perry Richard , Marquand Andre F. , Cole James H. , Malhotra Paresh 
Published: March 2024

AbstractINTRODUCTIONOverlooking the heterogeneity in Alzheimer's disease (AD) may lead to diagnostic delays and failures. Neuroanatomical normative modeling captures individual brain variation and may inform our understanding of individual differences in AD‐related atrophy.METHODSWe applied neuroanatomical normative modeling to magnetic resonance imaging from a real‐world clinical cohort with confirmed AD (n = 86). Regional cortical thickness was compared to a healthy reference cohort (n = 33,072) and the number of outlying regions was summed (total outlier count) and mapped at individual‐ and group‐levels.RESULTSThe superior temporal sulcus contained the highest proportion of outliers (60%). Elsewhere, overlap between patient atrophy patterns was low. Mean total outlier count was higher in patients who were non‐amnestic, at more advanced disease stages, and without depressive symptoms. Amyloid burden was negatively associated with outlier count.DISCUSSIONBrain atrophy in AD is highly heterogeneous and neuroanatomical normative modeling can be used to explore anatomo‐clinical correlations in individual patients.
A dog's life: Early life histories influence methylation of glucocorticoid (NR3C1) and oxytocin (OXTR) receptor genes, cortisol levels, and attachment styles
Authors: Awalt Samantha L. , Boghean Lidia , Klinkebiel David , Strasser Rosemary 
Published: March 2024

AbstractEarly life deprivation and stress can contribute to life‐long, problematic consequences, including epigenetic variations related to behavior and health. Domestic dogs share human environments and social–cognitive traits, making them a promising comparative model to examine developmental plasticity. We examined 47 owner–dog dyads, including dogs rescued from abusive or neglectful environments, and matched control dogs for changes in DNA methylation of glucocorticoid (NR3C1) and oxytocin (OXTR) receptor genes previously shown to be affected by early life stress in other species including humans. We used an attachment paradigm, which included a separation event to examine cortisol levels and owner–dog attachment styles. Overall, dogs with adverse histories had different NR3C1 methylation patterns as a function of age and less OXTR methylation than comparison dogs. Dogs with adverse histories did not differ in their cortisol change from baseline to poststressor from comparison dogs, but the change in cortisol was associated with NR3C1 methylation. In addition, dogs with a history of early life stress had more insecure attachment styles; for every unit increase of OXTR methylation, the odds increased for insecure attachment style. This study demonstrates that adverse life histories lead to methylation differences, resulting in the hypothalamic–pituitary–adrenal (HPA) axis's dysregulation and differences in behavioral phenotypes.
Resting respiratory sinus arrhythmia moderates the within‐person relations of parental emotional expressivity and children's prosocial behaviors
Authors: Zhang Runzhu , Wang Zhenhong 
Published: March 2024

AbstractParental supportive emotional expressivity could contribute to children's prosocial behaviors, and such an effect may differ for children with different levels of resting respiratory sinus arrhythmia (RSA). This study disentangled the stable differences across dyads (i.e., between‐person effects) from the dynamic associations between parental expressivity and children's prosocial behaviors within dyads (i.e., within‐person effects) and determined how resting RSA functioned as a susceptibility factor in such effects. The longitudinal design consisted of three measurements with a 1‐year interval performed among 208 school‐aged children (48.6% girls; Han nationality) and their parents (153 mothers and 55 fathers). The initial measurement was conducted when the children were 7 years old (Mage = 7.13, SDage = .33). Resting RSA was calculated at the first measurement; parents reported children's prosocial behaviors and parental expressivity at each of the three measurements. The results demonstrated significant between‐ and within‐person effects of parental expressivity on children's prosocial behaviors and found a moderating role of children's resting RSA in the within‐person effects. These findings suggest that children displayed more prosocial behaviors when parents showed more supportive expressivity both across and within dyads, and higher resting RSA operated as a differential susceptibility factor in the intraindividual fluctuations in parental expressivity.
Catastrophic storms, forest disturbance, and the natural history of Swainson's warbler
Authors: Graves Gary R. 
Published: March 2024

AbstractThe core breeding range of Swainson's warbler (Limnothlypis swainsonii) overlaps a zone of exceptionally high tornado frequency in southeastern North America. The importance of tornadoes in creating breeding habitat for this globally rare warbler and other disturbance‐dependent species has been largely overlooked. This paper estimates tornado frequency (1950–2021) and forest disturbance in the 240 counties and parishes in which breeding was documented from 1988 to 2014. The frequency of destructive tornadoes (EF1‐EF5) varied 6‐fold across the breeding range with a peak in the Gulf Coast states. Counties from east Texas to Alabama experienced the lowest median return interval of 5.4 years per 1000 km2, resulting in approximately 2477 ha of forest damage per 1000 km2 per century, based on current forestland cover. Tornadoes were significantly less frequent north and east of the core breeding range, with return intervals increasing to 9.1 years per 1000 km2 for breeding counties on the Atlantic coastal plain, 10.2 years per 1000 km2 in the Ozark Mountains, and 32.3 years per 1000 km2 in the Appalachian Mountains. Breeding counties within 150 km of the coastline from east Texas to North Carolina are also subjected to the highest frequency of hurricanes in the Western Hemisphere. Hurricanes often cause massive forest damage but archived meteorological and forestry data are insufficient to estimate the aggregate extent of forest disturbance in breeding counties. Nevertheless, the combined impact of tornadoes and hurricanes in the pre‐Anthropogenic era was likely sufficient to produce a dynamic mosaic of early‐successional forest crucial for the breeding ecology of Swainson's warbler. To ensure the long‐term survival of this rare warbler, it is advisable to develop habitat management plans that incorporate remote sensing data on early‐successional forest generated by catastrophic storms as well as anthropogenic activities.
Host plant‐mediation of viral transmission and its consequences for a native butterfly
Authors: Christensen Tara , Dyer Lee A. , Forister Matthew L. , Bowers M. Deane , Carper Adrian , Teglas Mike B. , Hurtado Paul , Smilanich Angela M. 
Published: March 2024

AbstractPathogens play a key role in insect population dynamics, contributing to short‐term fluctuations in abundance as well as long‐term demographic trends. Two key factors that influence the effects of entomopathogens on herbivorous insect populations are modes of pathogen transmission and larval host plants. In this study, we examined tritrophic interactions between a sequestering specialist lepidopteran, Euphydryas phaeton, and a viral pathogen, Junonia coenia densovirus, on its native host plant, Chelone glabra, and a novel host plant, Plantago lanceolata, to explore whether host plant mediates viral transmission, survival, and viral loads. A two‐factor factorial experiment was conducted in the laboratory with natal larval clusters randomly assigned to either the native or novel host plant and crossed with either uninoculated controls or viral inoculation (20% of individuals in the cluster inoculated). Diapausing clusters were overwintered in the laboratory and checked weekly for mortality. At the end of diapause, all surviving individuals were reared to adulthood to estimate survivorship. All individuals were screened to quantify viral loads, and estimate horizontal transmission postmortem. To test for vertical transmission, adults were mated, and the progeny were screened for viral presence. Within virus‐treated groups, we found evidence for both horizontal and vertical transmission. Larval clusters reared on the native host plant had slightly higher horizontal transmission. Survival probability was lower in clusters feeding on the native host plant, with inoculated groups reared on the native host plant experiencing complete mortality. Viral loads did not differ by the host plant, although viral loads decreased with increased sequestration of secondary compounds on both host plants. Our results indicate that the use of a novel host plant may confer fitness benefits in terms of survival and reduced viral transmission when larvae feeding on it are infected with this pathogen, supporting hypotheses of potential evolutionary advantages of a host range expansion in the context of tritrophic interactions.
A comprehensive overview of DC‐DC converters control methods and topologies in DC microgrids
Authors: Sarvi Mohammad , Zohdi Homa Zarei 
Published: March 2024

AbstractMicrogrids with large‐scale photovoltaic systems constitute a large part of distributed renewable generation in many grids around the world. Managing the performance of such microgrids and especially their interaction with the main power grid is a challenging task, because it requires the control of renewable resources. This paper presents a comprehensive overview of DC‐DC converter structures used in microgrids and presents a new classification for converters. This paper also provides an overview of the control techniques of DC‐DC converters in DC microgrids and the advantages and disadvantages of the control methods are discussed. In connection with the increasing penetration of distributed generation sources (DGS) and renewable sources in power systems and their power management has been raised as a major concern and methods for power management have been investigated in this paper. Finally, a DC microgrid system, which includes a solar system, wind turbine, and battery, is simulated in MATLAB/Simulink software and its performance is analyzed.
Mutation boosted salp swarm optimizer meets rough set theory: A novel approach to software defect detection
Authors: Sekaran Kripa , Lawrence Sherly Puspha Annabel 
Published: March 2024

AbstractSoftware defect detection (SDD) is crucial to ensure the reliability of software systems and identify defects in classification. One of the key challenges in defect detection is to select more informative and relevant features from the vast pool of available software metrics. A novel approach is proposed in this paper that leverages mutation boosted salp swarm optimizer (MBSSO) and Rough Set Theory for feature selection (FS) in SDD. It efficiently explores the search space and incorporates a mutation boosting mechanism to overcome local optima. Rough Set Theory provides a formal framework for analyzing feature relevance and dependency, while MBSSO optimizes the search for the optimal feature subset. The proposed approach involves encoding the feature subsets using binary representation and designing a fitness function. The MBSSO algorithm explores the feature space, iteratively improving the feature subset based on the fitness function. The selected feature subset is then used to train a defect detection model using the Kernel Extreme Learning Machine (KELM) algorithm. The experimental validation is performed by Project Repository for Software Engineering (PROMISE) dataset and compared the performance of proposed approach against other FS methods and baselines. The experimental validation demonstrates that the proposed approach achieves superior performance and selected feature subset improves the accuracy and efficiency. This research contributes to the advancement of SDD by providing an effective and efficient FS technique using MBSSO and Rough Set Theory.
A systematic assessment of the revised Nutri‐Score algorithm: Potentials for the implementation of front‐of‐package nutrition labeling across Europe
Authors: Hafner Edvina , Pravst Igor 
Published: March 2024

AbstractFront‐of‐package nutrition labeling (FOPNL) is an important public health tool, and the introduction of harmonized FOPNL in Europe is one of the most ambitious food labeling changes in decades. Nutri‐Score (NS) has been considered for implementation across Europe. However, NS is subject to strong opposition, particularly from the food industry and some agricultural sectors (such as cheese and cured meat), but also from some nutrition scientists and public health professionals, which highlights that the system is not sufficiently aligned with food‐based dietary guidelines and the latest scientific literature. These concerns were recently addressed in a revised version of NS (NS2023), aiming to overcome the limitations of its predecessor (NS2021). Our aim was to assess whether these limitations were addressed and to investigate their alignment with dietary guidelines. A systematic literature review identified 20 limitations of NS, assigned to 3 groups (Food‐based, Component‐based, and Other Dimensions of Food Quality). Subsequent assessment of NS employed a large representative branded food database of 19,510 pre‐packed foods. Alignment with dietary guidelines was assessed based on agreement with the WHO Europe nutrient profile (WHOE). NS2023 was shown as notably stricter compared to NS2021 (7% fewer products received the higher grades A or B) and more aligned with WHOE (κNS2021 = .59, κNS2023 = .65). Overall, most (65%) of the limitations were addressed to some extent; these were mostly Food‐based limitations, followed by Component‐based, whereas the Other Dimension of Food Quality (processing, sustainability, portion sizes) remained mostly unaddressed. We can conclude that the revised NS2023 increased its potential for implementation across Europe. Our review identified all limitations, relevant or not, which were mentioned in the scientific literature. Therefore, some mentioned limitations may never be solvable in the scope of nutrient profiling. Others could be further addressed by adaptation of the visual presentation, but increased complexity of the labeling message would also reduce the potential of the FOPNL to support consumers in healthier food choices. Additional research is also necessary to explore the potential impact of the revised NS2023 on food reformulation and its perception among consumers.
Systemic versus localized Bacillus Calmette Guérin immunotherapy of bladder cancer promotes an anti‐tumoral microenvironment: Novel role of trained immunity
Authors: Atallah Aline , Grossman Arielle , Nauman Richard W. , Paré Jean‐François , Khan Adam , Siemens D. Robert , Cotechini Tiziana , Graham Charles H. 
Published: March 2024

AbstractTreatment for higher‐risk non‐muscle invasive bladder cancer (NMIBC) involves intravesical immunotherapy with Bacillus Calmette Guérin (BCG); however, disease recurrence and progression occur frequently. Systemic immunity is critical for successful cancer immunotherapy; thus, recurrence of NMIBC may be due to suboptimal systemic activation of anti‐tumor immunity after local immunotherapy. We previously reported that systemically acquired trained immunity (a form of innate immune memory) in circulating monocytes is associated with increased time‐to‐recurrence in patients with NMIBC treated with BCG. Herein, we used a mouse model of NMIBC to compare the effects of intravesical versus intravenous (systemic) BCG immunotherapy on the local and peripheral immune microenvironments. We also assessed whether BCG‐induced trained immunity modulates anti‐tumor immune responses. Compared with intravesical BCG, which led to a tumor‐promoting immune microenvironment, intravenous BCG resulted in an anti‐tumoral bladder microenvironment characterized by increased proportions of cytotoxic T lymphocytes (CTLs), and decreased proportions of myeloid‐derived suppressor cells. Polarization toward anti‐tumoral immunity occurred in draining lymph nodes, spleen, and bone marrow following intravenous versus intravesical BCG treatment. Pre‐treatment with intravesical BCG was associated with increased rate of tumor growth compared with intravenous BCG pre‐treatment. Trained immunity contributed to remodeling of the tumor immune microenvironment, as co‐instillation of BCG‐trained macrophages with ovalbumin‐expressing bladder tumor cells increased the proportion of tumor‐specific CTLs. Furthermore, BCG‐trained dendritic cells exhibited enhanced antigen uptake and presentation and promoted CTL proliferation. Our data support the concept that systemic immune activation promotes anti‐tumor responses, and that BCG‐induced trained immunity is important in driving anti‐tumor adaptive immunity.
Does environmental credit affect bank loans? Evidence from Chinese A‐share listed firms
Authors: Yin Shihao , Lin Zhongguo , Li Panni , Peng Binbin 
Published: March 2024

AbstractWe investigate the effect of government‐initiated enterprise environmental credit ratings on firms' bank loans. While prior research indicates that companies with superior environmental performance tend to secure more bank loans, it is crucial to acknowledge that these performance metrics predominantly rely on voluntary corporate social responsibility or environmental, social, and governance disclosures made by the firms themselves or evaluated by third‐party agencies. Consequently, the evaluation results could be biased due to incomplete information disclosure, methodologies, or systems, raising concerns among scholars about potential “greenwashing” or symbolic environmental actions. In contrast, we employ a dataset comprising 27,388 observations from 2009 to 2021, applying propensity score matching and a time‐varying difference‐in‐difference model to better discern the relationship between firms' environmental credit ratings and their ability to obtain bank loans. Our findings highlight that firms participating in environmental credit evaluation can secure more bank loans compared to non‐participating firms. This effect is especially pronounced in regions with advanced green finance development. Further analysis shows that non‐state‐owned enterprises with excellent or good environmental credit ratings receive more loans, thus mitigating ownership bias in loan distribution. Overall, our results demonstrate that mandatory government environmental credit ratings mitigate information asymmetry by enabling lenders to better understand firms' environmental information.
Antimicrobial therapy outcomes in acute cholangitis: Hilar multiple obstructions versus single hilar and common bile duct obstructions
Authors: Masuda Sakue , Imamura Yoshinori , Jinushi Ryuhei , Kubota Jun , Kimura Karen , Makazu Makomo , Sato Ryo , Kako Makoto , Kobayashi Masahiro , Uojima Haruki , Ichita Chikamasa , Koizumi Kazuya 
Published: March 2024

AbstractBackground and AimThe appropriate duration of antimicrobial therapy for acute cholangitis (AC) arising from multiple hilar biliary obstructions as opposed to simple obstruction in the extrahepatic bile duct has not been established. This study assessed the efficacy of the duration of antimicrobial treatments in the Tokyo Guidelines 2018 for AC based on the cause and site of obstruction.MethodsThis single‐center retrospective study involved patients with AC who underwent successful biliary drainage and completed a 7‐day or shorter antimicrobial treatment. Patients were categorized into three groups: Group 1, bile duct stone or benign obstruction; Group 2, simple biliary obstruction due to malignancy; and Group 3, multiple hilar biliary obstruction due to malignancy. The primary outcome was clinical cure rate, and the secondary outcomes were 3‐month recurrence rate and length of hospital stay.ResultsA total of 373 patients were selected. Patients in Group 3 were younger or had Charlson Comorbidity Index ≥4, and had fewer positive blood cultures. In Group 3, the clinical cure rate (87.1%) and 3‐month recurrence rate (32.3%) were less favorable than those in the other groups. In Group 1, the clinical cure rate was significantly higher (98.1%, P = 0.02) with a much lower 3‐month recurrence rate of only 3.4% (P < 0.001) than that in the other groups. The median hospital stay for all groups was 7 days.ConclusionThis study suggests that the outcomes in Group 3 may be worse than those in Groups 1 or 2, regardless of the duration of the antibiotic treatment.
Intra‐Asian Creativity in Hong Kong Education and Activism
Authors: Harris Daniel X. , Chan Kelly Ka‐Lai 
Published: March 2024

ABSTRACTThis essay draws on empirical research from two studies examining creativity, activism, and education in Hong Kong. We use a decolonizing and deimperializing approach to centering creativity as a lever for social change, and demonstrate the ways in which the specifics of culture, region, time, and place uniquely produce forms of creativity, as has long been documented by creativity scholars. We build upon Kuan‐hsing Chen's Asia as Method: Toward Deimperialization (2010), applying it to creativity and the ways in which we can better attend to cultural and regional differences rather than adhere to universalizing “creative industries” or developmental psychological discourses. Here we are not interested in documenting “non‐western” modes of creativity, in the ways this has sometimes been addressed as local craft or traditional cultural practices. Rather, we advance a theory of intra‐Asian creativity (including Australia) with its own onto‐epistemological legacies and innovations. We celebrate these formations as emergent from and imbricated with conceptual traditions such as Taoism and Western knowledge systems, rejecting binarized individualist “versus” collectivist approaches. The emerging field of critical creativity studies points to the ways in which decolonizing, deimperializing and collaborative research are reorienting our work toward benefit for all, rather than the (white) (western) few.