bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formulation And In Vitro, In Vivo Evaluation of Colon Targeted Drug Delivery System Of 5-Fluorouracil
Authors: S Subimol. , Pathan Amjadkhan A. 
Published: April 2024

Colon-targeted drug delivery systems can provide therapeutic benefits including better patient compliance and lower costs. The present investigation is aimed to design a colon specific microbially triggered system using biodegradable co-polymer mixtures. The calibration curves of 5-FU were measured in distilled water, 0.1N HCl and phosphate buffer of pH 6.8 and 7.4 which showed good linearity. Compatibility study of pure drugs, excipients and their physical mixtures were evaluated and passed as per standards. Solubility determination was carried out in different solvents. Satisfactory results were found from evaluation of micromeritic parameters such as flow property, in-vitro dissolution study and kinetic study. The prime focus of the study was to design and evaluate a swelling dependent delayed release system for a colonic delivery of anticancer agent 5-Fluorouracil (5-FU) and further to determine the effects of carboxy polymer (Carbopol 71G-NF) on release behavior of 5-FU from a matrix tablet system containing different amounts of inulin (a biodegradable oligofructose) aiding in enzymatic degradation by colonic microflora. Mixed film coating with a blend of Ethyl cellulose: Eudragit®S-100 (2:1) at coat weight levels of 2%w/w, 4%w/w and 6.0%w/w was carried out respectively, which further retarded the drug release in the initial hours of the in-vitro dissolution profile. Swelling studies were also carried out on uncoated matrix tablet batches. The releases studies with or without rat cecal contents were performed on optimized batches and the samples were analyzed by a validated RP-HPLC method. In-vitro rat cecal study results revealed that complete drug release would occur from the tablets in the human colonic microenvironment. The study revealed an effective site-specific delivery of a hydrophilic chemotherapeutic agent, 5-FU to the colon for the treatment of various local as well as systemic pathologies.
An Analytical Study Of The Status Of Using Video-Based Online Learning In India (With Special Reference To SVBOLT And AVBOLT)
Authors: Gaur Mayank 
Published: April 2024

New Media technology is changing education patterns rapidly. Online learning became an essential part of Education after COVID-19. The research explored the status of video-based online learning, the effectiveness of SVBOLT (synchronous video-based online teaching and learning) and AVBOLT (asynchronous video-based online learning and teaching), and the barriers and solutions to those encountered during online video-based learning. 80 teachers and 160 students from India's different regions, like Rajasthan, Uttar Pradesh, and Haryana, participated in this study. The study was conducted on students of the 8th class and above standard. Teachers were selected who teach the students through offline and online modes. Samples were collected randomly from the questionnaire via online and offline modes. The result states that while learning with the SVBOLT platform, students have to face various problems. During live webcasts through various apps, there is a fixed study time and place that cannot be changed, if, during this time they face internet connectivity issues, students can suffer from the problems. AVBOLT reduces the obstacles that were faced in learning through SVBOLT. AVBOLT is an effective platform compared to SVBOLT. AVBOLT enhances the teaching and learning experience. Some aspects should be prioritized for effective online learning, such as Teachers should be trained for presentation in front of the camera and should have the necessary technical knowledge related to PPT (PowerPoint Presentation). AVBOLT provides error-free, quality content to learners. The use of this blended education method (online and offline learning) is a worthy step in the direction of making studies completely online with new technologies. However, the institutes and the schools will have to ensure that their content is technically and educationally sound.
A systematic review of the questionnaire used in oral health knowledge, attitudes, and practices in 12 years old children in the Dental Hospital Department of Pediatric Dentistry Baiturrahmah University
Authors: Utami Sri P. , Mahata Intan BE. , Lisfrizal Hamdy 
Published: April 2024

Objective: The purpose of this study was to determine a systematic review of the questionnaire used on oral health knowledge, attitudes, and practices in children aged 12 years in the Dental Hospital Department of Pediatric Dentistry Baiturrahmah University.
Methods: This type of research is a descriptive analytic study with are search design cross sectional. The population of this study was 12 year old children who came to the Paedodonti Department of Baiturrahmah Hospital in January 2020-March 2020 with a total sample of 68 people. The research was conducted at the Dental Hospital Department of Pediatric Dentistry Baiturrahmah University in January 2020-March 2020 using a questionnaire. The data obtained from this study were analyzed statistically using the application SPSS with descriptive analysis.
Results: The results showed that the kueisoner review at the level of knowledge and attitude was very good, while the action was quite good.
Conclusion: The conclusion of this study is where the level of knowledge and attitudes of 12 year olds at Dental Hospital Department of Pediatric Dentistry Baiturrahmah University, is already very good, while the actions pretty good. Knowledge, attitudes and actions of all these components play an important role in influencing the level of dental and oral hygiene in children.
Hydrophobicity of the biofunctionalized scaffolds for bone tissue engineering application in dentistry
Authors: Hatta Ridhayani , Monteiro Beatriz JC. , Asencio Ílida O. 
Published: April 2024

Objective: This study aimed to characterize the hydrophobicity of the functionalized scaffolds for bone tissue engineering applications in Dentistry.
Materials and Methods: This experimental study was conducted in the Tissue Engineering Laboratory of The University of Sheffield. The scaffolds were polycaprolactone (PCL) and functionalized using heparin, divided into five groups of prepared electrospun scaffolds. i.e., 1) Fully coated heparin, 2) Random drops of heparin, 3) Organized drops of heparin, 4) Stamping-micropockets with heparin, 5) PCL scaffold only (Control). Hydrophobicity was characterized by measuring the contact angle of distilled water drops on the scaffolds. One-way ANOVA was used as a data analysis test, with p<0.05.
Result: The mean contact angle of each group was 63.33, 63.83, 63.33, 73.00, and 64.58, respectively. There was no group of scaffolds categorized as hydrophobics and no statistically significant difference among and within groups.
Conclusion: The functionalized scaffolds were mostly un-hydrophobic, being a deliberation of their biocompatibility and role in bone tissue engineering application in dentistry.
The characteristics of mandibular fracture in Dr. Hasan Sadikin General Hospital Bandung, Indonesia
Authors: Stevhany Agnesthesia R. , Farah A. Putri  , Winarno Priyanto  
Published: April 2024

ABSTRACT
INTRODUCTION Mandibular fracture poses a fatal complication because the mandible plays an essential role in occlusion and aesthetics. The mandible is one of the bones most affected by facial fractures commonly resulting from trauma to the face and may be associated with severe morbidity and serious consequences METHODS The records of 282 patients referred to RSUP Dr. Hasan Sadikin General Hospital Bandung, Indonesia between January 2017 and January 2021 were analysed retrospectively. Data including age, sex, etiology of mandibular fracture, type of mandibular fracture, and treatment. Incompleted data from the medical record were excluded.
RESULTS Men aged 17-30 years were the most common victims of mandibular fracture. Road traffic accidents (RTAs) were responsible in 84% of cases. The most common anatomic site for mandibular fracture was parasymphysis region 28.7 with simple fractures 79%, and 82% of the total fractures were treated with open reduction
CONCLUSION The characteristics of mandibular fracture patients describe trauma patterns in the community. This finding is similar with some readily available literature with RTAs was the most common etiology and parasymphysis was the most common fracture site. Reasons for this high frequency may include the large number of poorly maintained, overloaded vehicles on unsuitable roads, violation of traffic regulations particularly by inexperienced young drivers.
Anti-Osteoclastogenesis effects of gambir extract gel in periodontitis
Authors: Hervina  , Syahriel Dwis , Haryani IGA D. , Adnyasari NLP SM. , Nasutianto Haris 
Published: April 2024

Objective: RANK-RANKL-OPG signaling is being considered as the pathway periodontitis induces osteoclastogenesis. Alveolar bone resorption and increased osteoclast activity are both triggered by a greater RANKL/OPG ratio in periodontitis. Gambir contains catechins and quercetin, which have antimicrobial, antioxidant, and anti-inflammatory properties. This study aimed to analyze the anti-osteoclastogenesis effect of gambir extract gel through RANKL and OPG serum levels, the number of osteoblasts, and osteoclasts in alveolar bone tissue of Wistar rats. Material and Methods: Twenty-four male Wistar rats were divided into four equal groups, each receiving a different treatment: Group I received a placebo gel, Group II received Tetracycline gel, Group III received 8% gambir extract gel, and Group IV received 10% gambir extract gel. After 21 days, the serum levels of RANKL and OPG were assessed using ELISA. Hematoxylin-eosin staining of the bone tissue preparation was followed by microscopic counting of osteoblasts and osteoclasts. Results: Significant differences in RANKL serum levels were seen in Group I (0.70 + 0.020) with Group III (0.031 + 0.014) (p=0.018) and Group I with Group IV (0.038 + 0.012) (p=0.041). Serum levels of OPG differed significantly between Groups I (0.165+0,125) and IV (0.536+0.182) p=(0.015). The number of Osteoblast in Group I (1.16+ 0.40) and IV (1.33+1.03) were significantly different (p=0.023). The number of Osteoclast in Group I (4.33+1.50) and IV (1.5+0.83) were significantly different (p=0.008). Conclusion: Gambir Extract Gel 10% inhibits osteoclastogenesis by increasing osteoblast and decreasing osteoclast numbers by more than 8%, decreasing RANKL, and elevating OPG serum levels.

Keywords: Gambir Extract Gel, Osteoclastogenesis, Periodontitis
Freeze-Dried human platelet-rich plasma effect on osteoblast number and collagen density in periodontitis treatment
Authors: Nandini A. Sumitro  , Hapsari K. Prathivi  , Kwartarini Murdiastuti  
Published: April 2024

Objective: This study aimed to determine the effect of FD-hPRP on the number of osteoblast and collagen density in periodontitis treatment by a histomorphometric study on oryctolagus cuniculus rabbits' alveolar bone and periodontal ligament.
Material and Methods: Sixteen male rabbits were randomly divided into four groups: Normal; Periodontitis; FD-hPRP; DFDBA. After periodontal surgery by open flap debridement, FD-hPRP was applied in group 3, and DFDBA was applied in group 4. Then all rabbits were decapitated eight weeks after surgery. Histomorphometric analysis calculates the number of osteoblasts and collagen density using image J software. Data were analyzed using one-way ANOVA followed by Post Hoc Least Significant Difference (LSD) test.
Results: The results showed a significant difference (p>0.05) between the periodontitis and FD-hPRP and also DFDBA group.
Conclusion: The application of FD-hPRP effect increases the number of osteoblast and collagen density in periodontitis treatment histomorphometrically in rabbit’s alveolar bone and periodontal ligament.
Reporting the impact of artemisinin resistance: Molecular surveillance of pfK13 and pfEXO mutations in Plasmodium falciparum in Southern provinces of Vietnam
Authors: Thu Huyen Tran Thi , Van Khanh Le , Thu Hien Bui Thi , Lan Dung Nguyen Thi , Van Long Nguyen , Dang Ton Nguyen 
Published: April 2024

Background: Malaria, mainly caused by Plasmodium falciparum, is a major global health concern. In Vietnam, resistance to artemisinin-based combination therapies (ACTs) is rising, jeopardizing malaria control efforts. This study focuses on mutations in the pfK13 and pfEXO genes, particularly the E415G mutation, in Southern Vietnam.
Methods: The study involved 421 patients across two cohorts. The first, with 63 patients from Binh Phuoc and Dak Nong, had uncomplicated P. falciparum malaria and were part of the Therapeutic Efficacy Studies (TES), treated according to WHO guidelines (2009). The second cohort, comprising 358 patients from the Central Highlands, aimed to assess mutation frequency in genes linked to artemisinin resistance. Molecular marker analysis, including Sanger sequencing for pfK13 and ARMS-PCR for E415G in pfEXO, was conducted. The study also examined the association of these mutations with Day 3 parasitemia and treatment outcomes using Dihydroartemisinin-Piperaquine (DHA-PPQ).
Results: Most cases showed mutations in pfK13, linked to delayed parasite clearance and higher treatment failure, indicating pfK13 as a key marker for artemisinin resistance. The E415G mutation in pfEXO was common but not significantly associated with resistance or treatment outcomes, though there was a tendency towards increased treatment failure among these patients. Conclusion: Our study implies the critical role of the C580Y mutation in the pfK13 gene in artemisinin resistance and its impact on the efficacy of ACTs in Vietnam. The findings highlight the necessity for monitoring these mutations as molecular markers for drug resistance and call for the exploration of alternative treatment strategies in the face of evolving antimalarial drug resistance. This study contributes valuable insights to the molecular epidemiology of malaria in Southern provinces in Vietnam and emphasizes the urgency of addressing artemisinin resistance in the global fight against malaria.
Key words: pfK13, E415G , artemisinin resistance, P. falciparum, malaria.
Riesgos ergonómicos aplicados al teletrabajo
Authors: Carvajal-Villamizar Henny Patricia 
Published: April 2024

Los riesgos laborales en el teletrabajo actualmente son materia de investigación en seguridad y salud en el trabajo, debido a la adaptación inesperada de las condiciones de trabajo por ser una opción para que las empresas prevengan el contagio de COVID-19 (SARS-2-Cov). Según la Ley 1221 de 2008 (Decreto Reglamentario 0884 de 2012) el teletrabajo es una forma de organización laboral que consiste en el desempeño de actividades remuneradas o prestación de servicios a terceros, utilizando como soporte las tecnologías de información y comunicación para el contacto entre el trabajador y la empresa, sin requerirse la presencia física del trabajador en un sitio específico de trabajo.
En este sentido, lugar de trabajo puede ser cualquier entorno en el cual se trabaja, incluidos el hogar y la calle. Cada uno de estos espacios trae consigo una serie de riesgos a los cuales pueden estar expuestos los trabajadores, es por eso que este capítulo tiene como objetivo informar sobre la incidencia de riesgos ergonómicos en el teletrabajo, material y métodos, en cuanto a la documentación y revisión de información; se realizó la búsqueda de fuentes secundarias, encontradas en diferentes bases de datos a nivel internacional como nacional; entre ellas se encuentran Scopus y ScienceDirect, Scielo y Dialnet.
En cuanto a los resultados y discusión, los principales factores que afectan esta modalidad de trabajo son los ergonómicos, analizando específicamente la ergonomía física la cual estudia las condiciones medioambientales (ruido, iluminación y temperatura) y los riesgos ergonómicos a los cuáles están expuestos los trabajadores. En relación con las conclusiones, el teletrabajo es una estructura organizacional que va en aumento por lo cual se hace necesario abordar medidas de prevención y control en seguridad y vigilancia para mejorar la calidad de vida de los trabajadores y mitigar los riesgos ergonómicos de mayor incidencia.
El reflejo de la verdad
Authors: Ramírez.Hernández Laura Valentina , Milena-Romero Sarah 
Published: April 2024

Esta es la historia de una joven obligada a ejercer la prostitucióndesde los 18 años como medio de sustento. Debido al radicalcambio de vida que enfrentó, su mente desarrolló un trastorno depersonalidad como mecanismo de defensa para aislarla de la realidad.María y Andrea, aunque compartían el mismo cuerpo, nuncallegarían a ser la misma persona.
Digital ISBN: 978-958-5142-35-0E-ISBN: 978-958-5142-36-7
Preliminares
Authors: Venegas-Camargo Allynson Karen 
Published: April 2024

Se presenta el segundo volumen del libro Casos empresariales: una visión desde la administración y la competitividad, el cual tiene dos grandes objetivos: primero, llegar a un lector interesado en situaciones empresariales reales; segundo, desarrollar el método prospectivo en empresas de diversos sectores, demostrando así que el tamaño no es un impedimento para el logro de nuevas posibilidades en la dirección de empresas.
Los estudios de caso han sido por más de 100 años un acercamiento a la realidad empresarial, facilitando el conocimiento de diversas situaciones organizacionales a estudiantes, profesores, empresarios, gremios y a todo aquel que se sienta interesado en el ámbito de los negocios.
Los estudios de caso aquí presentados se han trabajado inicialmente en el aula, entre estudiantes y docentes del pregrado de Administración de Empresas y la Especialización en Gestión Empresarial, confiamos en el aporte que puedan dejar en ustedes.
Casos empresariales, Volumen III
Authors: Venegas-Camargo Allynson Karen , Espitia-López Hernando , Valbuena-Cruz Daniela , Pérez-Lemus Gabriel Andrés , Mateos-Sastoque José Alberto , Sabogal-Rodríguez Andrés Felipe , Lesmes-Turriago Gabriela , Menjura-Cortés Juan José , Mosquera-Rodríguez Manuela , Alarcón-Romero Paola Andrea , Camelo-Zarabanda Carlos , Betancur-Montañez Edwin , Suarez-Morales Angelmiro , Páez-Cantor Yeidy Lorena 
Published: April 2024

A continuación, se presenta el tercer volumen del libro Casos empresariales: una visión desde la administración y la competitividad; cabe anotar que, estos cuatro estudios empresariales surgen del trabajo entre estudiantes y docentes de los programas de pregrado de Administración de Empresas y la Especialización en Gestión Empresarial, de la Escuela de Administración y Competitividad del Politécnico Grancolombiano, con el apoyo de empresarios que han dado un espacio para conocer su realidad y en un común ejercicio entre academia y empresa. Estructura de la obra consiste en un primer capítulo, denominado “Evaluación de la capacidad internacional y la factibilidad comercial de una empresa marroquinera en Colombia”, el cual presenta un estudio sectorial en el que se toma como base la realidad de una empresa marroquinera; aquí se revisa la situación que ha enfrentado en los últimos dos años y se propone una estrategia de negocios con posibilidades de apertura de mercado en el exterior. Lo anterior se da aprovechando la madurez que ha alcanzado el comercio electrónico y la mayor visualización de los procesos de exportación para los empresarios colombianos. El segundo capítulo se enfoca en un análisis prospectivo para la empresa “Global Manager Investment S.A.S —asesoría y consultoría en migración”. Se aborda un tema que, a todas luces, se encuentra a la orden del día y llama la atención de los interesados en migrar a otro país, gracias a las diversas posibilidades laborales, académicas, de negocios que se presentan, sobre todo, en países desarrollados o con amplias posibilidades para mejorar la calidad de vida; por lo tanto, en este capítulo se proponen nuevas posibilidades para la empresa. El capítulo tres presenta un análisis estratégico para la empresa LPK Constructores, como resultado de una consultoría universitaria en la que se establece la situación actual que enfrenta la empresa frente al mercado y a sus procesos internos. Con estos resultados se proponen estrategias por seguir. En el capítulo cuatro se presenta el segundo análisis prospectivo de esta edición para la empresa Ferredistribuciones Éxito. Acá se identifican los escenarios futuros que la compañía tiene posibilidad de implementar en los próximos diez años; dichos escenarios se formulan con base en información brindada por el empresario y la investigación realizada en el transcurso de la consultoría.
ISBN digital: 978-628-7534-97-1
Evaluación con curvas de operación de métricas Seis Sigma el desempeño de sistemas productivos mixtos
Authors: Fontalvo Herrera Tomas , Mejia Zambrano Fabio , Oyuela Rodríguez Gabriela 
Published: April 2024

Objetivo: En esta investigación se proponen nuevas curvas de operación de las métricas seis sigma para evaluar el desempeño de un sistema productivo mixto (Serie y en paralelo). Marco teórico: Para lo anterior se utiliza como marco teórico los conceptos de curva de operación, control estadístico de la producción, métricas seis sigma y sistemas de producción mixto. Metodología: se aborda un enfoque heurístico y un análisis de sensibilidad para analizar el comportamiento de los defectos en parte por millón, rendimiento Y, para lo cual se proponen las curvas de operación al variar en rango de 0 a 6 el nivel sigma Z del sistema y de los procesos. Resultados: se muestran que el sistema productivo evidencia como máxima capacidad de desempeño de calidad en términos de sigma los valores de Z 5,25, 5,43 y 5,08 respectivamente para los procesos 1, 5, 6. Conclusión: Se aporta un método innovador que permite monitorear el desempeño de la calidad en condiciones cambiantes, y analizar como incide estos cambios en la reducción de defectos de cualquier sistema productivo
Information security as a path to information systems efficiency
Authors: Каримов Х.Т. , Андрианов В.А. , Пермяков В.Н. , Тархова Л.М. , Урманов В.Г. 
Published: April 2024

Рассматриваются вопросы, относящиеся к текущему состоянию безопасности компьютерных сетей. Производится анализ факторов, влияющих на безопасность компьютерных сетей. Поднимаются вопросы необходимости усиления безопасности компьютерных сетей и эффективности использования технологий шифрования для безопасности данных.
The article addresses the issues related to the current state of computer network security and the need to strengthen its security. An analysis of factors affecting the security of computer networks is carried out. The authors raise the question of the effectiveness of using encryption technology for data security and computer network security.