bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toll-Like Receptor 2-Dependent NF-κB Activation Is Involved in Nontypeable
Haemophilus influenzae
-Induced Monocyte Chemotactic Protein 1 Up-Regulation in the Spiral Ligament Fibrocytes of the Inner Ear
Authors: Moon Sung K. , Woo Jeong-Im , Lee Haa-Yung , Park Raekil , Shimada Jun , Pan Huiqi , Gellibolian Robert , Lim David J. 
Published: April 2007

ABSTRACT

Inner ear dysfunction secondary to chronic otitis media (OM), including high-frequency sensorineural hearing loss or vertigo, is not uncommon. Although chronic middle ear inflammation is believed to cause inner ear dysfunction by entry of OM pathogen components or cytokines from the middle ear into the inner ear, the underlying mechanisms are not well understood. Previously, we demonstrated that the spiral ligament fibrocyte (SLF) cell line up-regulates monocyte chemotactic protein 1 (MCP-1) expression after treatment with nontypeable
Haemophilus influenzae
(NTHI), one of the most common OM pathogens. We hypothesized that the SLF-derived MCP-1 plays a role in inner ear inflammation secondary to OM that is responsible for hearing loss and dizziness. The purpose of this study was to investigate the signaling pathway involved in NTHI-induced MCP-1 up-regulation in SLFs. Here we show for the first time that NTHI induces MCP-1 up-regulation in the SLFs via Toll-like receptor 2 (TLR2)-dependent activation of NF-κB. TLR2
−/−
- and MyD88
−/−
-derived SLFs revealed involvement of TLR2 and MyD88 in NTHI-induced MCP-1 up-regulation. Studies using chemical inhibitors and dominant-negative constructs demonstrated that it is mediated by the IκKβ-dependent IκBα phosphorylation and NTHI-induced NF-κB nuclear translocation. Furthermore, we demonstrated that the binding of NF-κB to the enhancer region of MCP-1 is involved in this up-regulation. In addition, we have identified a potential NF-κB motif that is responsive and specific to certain NTHI molecules or ligands. Further studies are necessary to reveal specific ligands of NTHI that activate host receptors. These results may provide us with new therapeutic strategies for prevention of inner ear dysfunction secondary to chronic middle ear inflammation.
IT SECURITY IN BIOMEDICAL IMAGING INFORMATICS: THE HIDDEN VULNERABILITY
Authors: CHEE W. S. ADAM 
Published: April 2007

The convergence of biomedical instruments and computing platforms has resulted in medical imaging equipment being subjected to the threats of malicious software (Malware) which have traditionally plagued the computing industry. Vulnerabilities increase several-fold with implementations of Clinical Information Systems like the Picture Archival & Communication Systems (PACS), where computer-based biomedical equipment work hand in glove with computer servers. With the increasing complexity of modern Malware, proactive monitoring and reviews of known vulnerabilities are no longer sufficient. An institute faced with an IT security attack on their medical networks will still experience extended downtime, performance degradation and increased service costs, even if equipped with an adequate security system and recovery plans. Biomedical equipment vendors usually need more time than computing vendors to validate the security updates required for vulnerabilities before they can recommend changes for installation to their systems. This includes all system changes, patches, updates, and enhancements. However, the interval between the launch of a new Malware attack and the availability of a solution from the vendor can result in the medical network being compromised and rendered totally crippled. In view of such new challenges, it is crucial to redesign your medical network and operating procedures to ensure continuous operation with minimum performance degradation even under a Malware attack until the biomedical equipment vendor can provide the software updates to resolve security vulnerabilities. Such strategic implementation is not only necessary to ensure integrity and confidentiality of patient's data but also to protect the healthcare institute's reputation and business continuity.
David Ibn Shoshan on Spirit and Soul
Authors: Langermann Y. Tzvi 
Published: April 2007

AbstractDavid Ibn Shoshan, a Jewish savant and a victim of the Spanish Expulsion of 1492, addresses the question of the status of the human spirit (rūah, rūh, pneuma) in the course of his commentary to Ecclesiastes. Spirit is the substrate of the soul; but as such, is it divine like the soul, so that it too ascends after death? Or is it rather purely material and hence perishable? After reviewing a number of medieval Islamic sources, Ibn Shoshan decides in favor of the view of Ibny Tufayl who, in his "philosophical romance" Hayy Ibn Yaqzān, declares the spirit to be divine. Among the interpretations that Ibn Shoshan rejects is that of "the authors of the Zohar." However, his critique is conducted entirely in a scientific idiom, without any polemical overtones. This is instructive insofar as it illustrates that kabbalists and natural philosophers of the period engaged on the whole in a constructive discourse based upon shared concepts. The texts studied here testifies to the endurance of Andalusian Jewish learning even after the expulsion of 1492. Indeed, perhaps Giordano Bruno mined some of the same sources utilized by Ibn Shoshan.
Zwischen den Stühlen? On the Taxonomic Anxieties of Modern Jewish Philosophy
Authors: Zank Michael 
Published: April 2007

AbstractAs a subfield of Jewish Studies modern Jewish philosophy is haunted by challenges arising from the culturally specific circumstances and original goals pursued by the Jewish philosophers of the past that are no longer immediately accessible. This essay looks at systematic and historical aspects of Jewish philosophy with the aim of determining ways of retrieving the plausibility of a taxonomically problematic field operating at the intersections of philosophy, history, religion, and Judaism.
A Numerical Study of Hurricane Erin (2001). Part II: Shear and the Organization of Eyewall Vertical Motion
Authors: Braun Scott A. , Wu Liguang 
Published: April 2007

Abstract
A high-resolution numerical simulation of Hurricane Erin (2001) is used to examine the organization of vertical motion in the eyewall and how that organization responds to a large and rapid increase in the environmental vertical wind shear and subsequent decrease in shear. During the early intensification period, prior to the onset of significant shear, the upward motion in the eyewall was concentrated in small-scale convective updrafts that formed in association with regions of concentrated vorticity (herein termed mesovortices) with no preferred formation region around the eyewall. Asymmetric flow within the eye was weak. As the shear increased, an azimuthal wavenumber-1 asymmetry in storm structure developed with updrafts tending to occur on the downshear to downshear-left side of the eyewall. Continued intensification of the shear led to increasing wavenumber-1 asymmetry, large vortex tilt, and a change in eyewall structure and vertical motion organization. During this time, the eyewall structure was dominated by a vortex couplet with a cyclonic (anticyclonic) vortex on the downtilt-left (downtilt-right) side of the eyewall and strong asymmetric flow across the eye that led to strong mixing of eyewall vorticity into the eye. Upward motion was concentrated over an azimuthally broader region on the downtilt side of the eyewall, upstream of the cyclonic vortex, where low-level environmental inflow converged with the asymmetric outflow from the eye. As the shear diminished, the vortex tilt and wavenumber-1 asymmetry decreased, while the organization of updrafts trended back toward that seen during the weak shear period. Based upon the results for the Erin case, as well as that for a similar simulation of Hurricane Bonnie (1998), a conceptual model is developed for the organization of vertical motion in the eyewall as a function of the strength of the vertical wind shear. In weak to moderate shear, higher wavenumber asymmetries associated with eyewall mesovortices dominate the wavenumber-1 asymmetry associated with the shear so that convective-scale updrafts form when the mesovortices move into the downtilt side of the eyewall and dissipate on the uptilt side. Under strong shear conditions, the wavenumber-1 asymmetry, characterized by a prominent vortex couplet in the eyewall, dominates the vertical motion organization so that mesoscale ascent (with embedded convection) occurs over an azimuthally broader region on the downtilt side of the eyewall. Further research is needed to determine if these results apply more generally.
Assessment of Physical Parameterizations Using a Global Climate Model with Stretchable Grid and Nudging
Authors: Coindreau O. , Hourdin F. , Haeffelin M. , Mathieu A. , Rio C. 
Published: April 2007

Abstract
The Laboratoire de Météorologie Dynamique atmospheric general circulation model with zooming capability (LMDZ) has been used in a nudged mode to enable comparison of model outputs with routine observations and evaluate the model physical parameterizations. Simulations have been conducted with a stretched grid refined over the vicinity of Paris, France, where observations, collected at the Trappes station (Météo-France) and at the Site Instrumental de Recherche par Télédétection Atmosphérique observatory, are available. For the purpose of evaluation of physical parameterizations, the large-scale component of the modeled circulation is adjusted toward ECMWF analyses outside the zoomed area only, whereas the inside region can evolve freely. A series of sensitivity experiments have been performed with different parameterizations of land surface and boundary layer processes. Compared with previous versions of the LMDZ model, a “thermal plume model,” in association with a constant resistance to evaporation improves agreement with observations. The new parameterization significantly improves the representation of seasonal and diurnal cycles of near-surface meteorology, the day-to-day variability of planetary boundary layer height, and the cloud radiative forcing. This study emphasizes the potential of using a climate model with a nudging and zooming capability to assess model physical parameterizations.
Radar Characteristics of Precipitation Features in the EPIC and TEPPS Regions of the East Pacific
Authors: Cifelli R. , Nesbitt S. W. , Rutledge S. A. , Petersen W. A. , Yuter S. 
Published: April 2007

Abstract
Ship-based radar data are used to compare the structure of precipitation features in two regions of the east Pacific where recent field campaigns were conducted: the East Pacific Investigation of Climate Processes in the Coupled Ocean–Atmosphere System (EPIC-2001; 10°N, 95°W) in September 2001 and the Tropical Eastern Pacific Process Study (TEPPS; 8°N, 125°W) in August 1997. Corresponding July–September 1998–2004 Tropical Rainfall Measuring Mission (TRMM) precipitation radar (PR) data are also used to provide context for the field campaign data. An objective technique is developed to identify precipitation features in the ship and TRMM PR data and to develop statistics on horizontal and vertical structure and precipitation characteristics. Precipitation features were segregated into mesoscale convective system (MCS) and sub-MCS categories, based on a contiguous area threshold of 1000 km2 (these features were required to have at least one convective pixel), as well as an “other” (NC) category. Comparison of the satellite and field campaign data showed that the two datasets were in good agreement for both regions with respect to MCS features. Specifically, both the satellite and ship radar data showed that approximately 80% of the rainfall volume in both regions was contributed by MCS features, similar to results from other observational datasets. EPIC and TEPPS MCSs had similar area distributions but EPIC MCSs tended to be more vertically developed and rain heavier than their TEPPS counterparts. In contrast to MCSs, smaller features (NCs and sub-MCSs) sampled by the ship radar in both regions showed important differences compared with the PR climatology. In the EPIC field campaign, a large number of small (&lt;100 km2), shallow (radar echo tops below the melting level) NCs and sub-MCSs were sampled. A persistent dry layer above 800 mb during undisturbed periods in EPIC may have been responsible for the high occurrence of these features. Also, during the TEPPS campaign, sub-MCSs were larger and deeper with respect to the TRMM climatology, which may have been due to the higher than average SSTs during 1997–98 when TEPPS was conducted. Despite these differences, it was found that for sizes greater than about 100 km2, EPIC precipitation features had 30-dBZ echos at higher altitudes and also had higher rain rates than similar sized TEPPS features. These results suggest that ice processes play a more important role in rainfall production in EPIC compared with TEPPS.
Atmospheric Circulation Associated with Persistent Generalized Frosts in Central-Southern South America
Authors: Müller Gabriela V. , Berri Guillermo J. 
Published: April 2007

Abstract
This paper describes the large-scale atmospheric circulation associated with persistent generalized frosts (GFs; at least 75% of the stations report frosts) in the east-central region of Argentina known as the Wet Pampa. The GF events are grouped according to their persistence, and NCEP–NCAR reanalysis data are used to create daily composites of mass and wind field anomalies during the 1961–90 winters. The GFs are caused by an anticyclonic anomaly that enters South America, generating southerly wind anomalies and cold air advection that are strengthened by the meridional layout of a cyclonic anomaly over the South Atlantic Ocean. In the case of the more persistent events the wind anomaly grows during the previous days and becomes quasi-stationary. Also, the study identifies at 250 hPa a double train of eastward-moving Rossby waves along the subtropical and subpolar latitudes, respectively, of the Southern Hemisphere. The layout of both wave trains favors the development of an intense southerly wind anomaly in the entire southern cone of the continent. On the other hand, the propagation pattern during the less persistent GFs shows only one arc-shaped Rossby wave train that reaches South America, and then propagates northeastward. Additionally, there is a subtropical jet entrance/confluence over the western side of the continent that induces a secondary meridional circulation whose subsiding branch facilitates the equatorward displacement of the low-level anticyclone, particularly in the case of the less persistent events. In the case of the more persistent GFs the confluence is located farther east and sustains essentially zonal wave train propagation, so that the surface anticyclone is not able to achieve a major equatorward penetration.
Retrieval of Moisture from Simulated GPS Slant-Path Water Vapor Observations Using 3DVAR with Anisotropic Recursive Filters
Authors: Liu Haixia , Xue Ming , Purser R. James , Parrish David F. 
Published: April 2007

Abstract
Anisotropic recursive filters are implemented within a three-dimensional variational data assimilation (3DVAR) framework to efficiently model the effect of flow-dependent background error covariance. The background error covariance is based on an estimated error field and on the idea of Riishøjgaard. In the anisotropic case, the background error pattern can be stretched or flattened in directions oblique to the alignment of the grid coordinates and is constructed by applying, at each point, six recursive filters along six directions corresponding, in general, to a special configuration of oblique lines of the grid. The recursive filters are much more efficient than corresponding explicit filters used in an earlier study and are therefore more suitable for real-time numerical weather prediction. A set of analysis experiments are conducted at a mesoscale resolution to examine the effectiveness of the 3DVAR system in analyzing simulated global positioning system (GPS) slant-path water vapor observations from ground-based GPS receivers and observations from collocated surface stations. It is shown that the analyses produced with recursive filters are at least as good as those with corresponding explicit filters. In some cases, the recursive filters actually perform better. The impact of flow-dependent background errors modeled using the anisotropic recursive filters is also examined. The use of anisotropic filters improves the analysis, especially in terms of finescale structures. The analysis system is found to be effective in the presence of typical observational errors. The sensitivity of isotropic and anisotropic recursive-filter analyses to the decorrelation scales is also examined systematically.
Nonlinear Horizontal Diffusion for GCMs
Authors: Becker Erich , Burkhardt Ulrike 
Published: April 2007

Abstract
The mixing-length-based parameterization of horizontal diffusion, which was originally proposed by Smagorinsky, is revisited. The complete tendencies of horizontal momentum diffusion, the associated frictional heating, and horizontal diffusion of sensible heat in spherical geometry are derived. The formulations are modified for the terrain-following vertical-hybrid-coordinate system in a way that ensures energy and angular momentum conservation at each layer. Test simulations with a simple general circulation model, run at T42 horizontal resolution and for permanent January conditions, confirm the conservation properties and highlight the enhancement of nonlinear horizontal diffusion in areas of high baroclinic activity. The simulated internal variability is dependent on the nature of the horizontal diffusion, with high-frequency variability being enhanced over the northern continents and low-frequency variability being increased (decreased) over the Pacific (Atlantic) Ocean when using nonlinear rather than linear diffusion. Locally reduced horizontal dissipation over Europe is compensated by increased dissipation owing to vertical diffusion, indicating the potential importance of nonlinear horizontal diffusion for gravity wave–resolving simulations. Inspection of the spectral energy reveals that the scheme needs to be modified in order to damp unbalanced ageostrophic motions at the smallest resolved scales more efficiently. A corresponding empirical modification is proposed and proves to work properly.
Close-Range Observations of Tornadoes in Supercells Made with a Dual-Polarization, X-Band, Mobile Doppler Radar
Authors: Bluestein Howard B. , French Michael M. , Tanamachi Robin L. , Frasier Stephen , Hardwick Kery , Junyent Francesc , Pazmany Andrew L. 
Published: April 2007

Abstract
A mobile, dual-polarization, X-band, Doppler radar scanned tornadoes at close range in supercells on 12 and 29 May 2004 in Kansas and Oklahoma, respectively. In the former tornadoes, a visible circular debris ring detected as circular regions of low values of differential reflectivity and the cross-correlation coefficient was distinguished from surrounding spiral bands of precipitation of higher values of differential reflectivity and the cross-correlation coefficient. A curved band of debris was indicated on one side of the tornado in another. In a tornado and/or mesocyclone on 29 May 2004, which was hidden from the view of the storm-intercept team by precipitation, the vortex and its associated “weak-echo hole” were at times relatively wide; however, a debris ring was not evident in either the differential reflectivity field or in the cross-correlation coefficient field, most likely because the radar beam scanned too high above the ground. In this case, differential attenuation made identification of debris using differential reflectivity difficult and it was necessary to use the cross-correlation coefficient to determine that there was no debris cloud. The latter tornado’s parent storm was a high-precipitation (HP) supercell, which also spawned an anticyclonic tornado approximately 10 km away from the cyclonic tornado, along the rear-flank gust front. No debris cloud was detected in this tornado either, also because the radar beam was probably too high.
The Influence of the Andes on Cutoff Lows: A Modeling Study*
Authors: Garreaud RenéD. , Fuenzalida Humberto A. 
Published: April 2007

Abstract
A cutoff low (COL) pressure system that occurred in March 2005 (late austral summer) over the subtropical southeast Pacific is examined by means of numerical simulations using the Weather and Research Forecasting (WRF) model. The episode exhibited typical features of COLs in this region, including its formation from an elongated northwest–southeast extratropical trough and subsequent intensification off the west coast of South America. During the developing stage, the cyclonic circulation did not extend into the lower troposphere and only upper-level, nonprecipitating clouds were observed at and around the system. When the COL reached the continent it produced moderate but unseasonal rainfall along the semiarid western slope of the Andes cordillera [summit level at ∼5000 m above sea level (ASL)] at the same time that the system experienced a rapid decay. The control simulation used full physics, full topography, and a single domain (54-km grid spacing) laterally forced by atmospheric reanalysis. Model results are in general agreement with upper-air, surface, and satellite observations, and allow a detailed description of the three-dimensional structure of the COL, as well as an evaluation of the vorticity and temperature budgets. A quasi-stationary, amplifying warm ridge over the South Pacific appears as the key precursor feature, in agreement with studies elsewhere. Once the COL formed, it drifted eastward mostly driven by vorticity advection induced by its own circulation, and there was close balance between vertical and horizontal temperature advection near its center. The jet streak along the COL’s periphery migrated from upstream of the COL axis, during the developing stage, to downstream later on. Four sensitivity experiments—reducing/removing topography, suppressing hydrometeors, and using an enlarged domain—were performed to assess the influence of the Andes, the importance of latent heat release, and the effect of the boundary conditions. Comparison among the control and sensitivity runs indicates that the COL formation occurs regardless of the presence of the Andes, and COL dissipation is mainly due to latent heat released in the deep clouds that form over the mountainous terrain. Nevertheless, the Andes cordillera delayed the COL demise by blocking the inflow of warm, moist air from the interior of the continent that otherwise would initiate deep convection in the region of ascending motion downstream of the COL.