bluuebunny/crossref_metadata_2025_split huggingface dataset:
Residual life modeling and maintenance planning for repairable systems
Authors: Ahmadi Reza , Sobhani Amirhossein , Rasaei Zohreh 
Published: March 2024

Abstract
Accepted by: Phil Scarf
This paper formulates a state-dependent mean residual lifetime model for a repairable system operating in a dynamic environment. The problem is addressed by means of a two-state damage process reflecting the effect of operating environment on the system and a repair process associated with the damage process. As the damage process shifts to a higher state, to maintain a minimum level of performance, the decision maker repairs the system at times that arise according to a point process with a constant intensity. We demonstrate the generality of the proposed model and show how existing models emerge as specific cases. Our approach stimulates further research on the determination of two types of maintenance policies: maintenance policy based on the number of imperfect repairs (Model I) and time-based maintenance policy (Model II). In both cases, using the renewal reward theorem argument, we aim at minimizing the long-run average maintenance cost per unit time by determining optimal replacement policies and the optimal level of imperfect repairs. We illustrate the proposed models and carry out a comparative analysis of maintenance policies through numerical examples. The main conclusions drawn are that repair and maintenance policies depend on the failure mechanism, repair frequency and the level of costs involved. Also, numerical comparison shows that the maintenance modelling based on the number of imperfect repairs (model I) outperforms the time-based replacement model (model II) and two baseline models ignoring the effect of operating environment or whose attention is restricted to perfect repair.
Advancing Diagnosis of Current Hepatitis C Virus Infection: A Key to Hepatitis C Elimination in the United States
Authors: Kamili Saleem , Wester Carolyn 
Published: March 2024

AbstractMore than 2 million adults have hepatitis C virus (HCV) infection in the United States, and new infections continue to increase. Without treatment, HCV infection can lead to advanced liver disease and death. Treatment is recommended for nearly everyone with hepatitis C, resulting in a cure in &gt;95% of people treated and raising the possibility of hepatitis C elimination. Testing is the first step to accessing life-saving treatment. The Centers for Disease Control and Prevention recommends hepatitis C screening for all adults, all pregnant persons, and anyone with risk; yet about one-third of people with hepatitis C remain unaware of their infection. Testing begins with a hepatitis C antibody test, followed, when reactive, by a nucleic acid test to detect HCV RNA. This antibody-first, 2-step testing strategy misses early infections and can result in incomplete diagnoses. Advancements in hepatitis C diagnostics and the US regulatory landscape have created an opportunity to include viral-first testing strategies and improve hepatitis C diagnosis. This journal supplement features 8 articles detailing challenges and opportunities for improving hepatitis C diagnostics in support of advancing hepatitis C elimination in the United States.
Comparative prebiotic potential of galacto- and fructo-oligosaccharides, native inulin, and acacia gum in Kenyan infant gut microbiota during iron supplementation
Authors: Momo Cabrera Paula , Rachmühl Carole , Derrien Muriel , Bourdet-Sicard Raphaëlle , Lacroix Christophe , Geirnaert Annelies 
Published: March 2024

Abstract
Iron fortification to prevent anemia in African infants increases colonic iron levels, favoring the growth of enteropathogens. The use of prebiotics may be an effective strategy to reduce these detrimental effects. Using the African infant PolyFermS gut model, we compared the effect of the prebiotics short-chain galacto- with long-chain fructo-oligosaccharides (scGOS/lcFOS) and native inulin, and the emerging prebiotic acacia gum, a branched-polysaccharide–protein complex consisting of arabinose and galactose, during iron supplementation on four Kenyan infant gut microbiota. Iron supplementation did not alter the microbiota but promoted Clostridioides difficile in one microbiota. The prebiotic effect of scGOS/lcFOS and inulin was confirmed during iron supplementation in all investigated Kenyan infant gut microbiota, leading to higher abundance of bifidobacteria, increased production of acetate, propionate, and butyrate, and a significant shift in microbiota composition compared to non-supplemented microbiota. The abundance of the pathogens Clostridium difficile and Clostridium perfringens was also inhibited upon addition of the prebiotic fibers. Acacia gum had no effect on any of the microbiota. In conclusion, scGOS/lcFOS and inulin, but not acacia gum, showed a donor-independent strong prebiotic potential in Kenyan infant gut microbiota. This study demonstrates the relevance of comparing fibers in vitro prior to clinical studies.
Severe astigmatism secondary to large intraocular lens pantoscopic tilt because of a malpositioned haptic following cataract surgery
Authors: Au Eong Jonathan T W , Tsai Jarryl H J , Au Eong Kah-Guan 
Published: March 2024

Abstract
An 80-year-old woman presented with painless blurring of vision and monocular diplopia in her left eye following routine phacoemulsification and monofocal intraocular lens (IOL) implantation 5 weeks earlier. Her uncorrected visual acuity (VA) was 6/60 correctable with pinhole to 6/21. Her best-corrected VA was 6/15 with a subjective refraction of −0.50DS/−5.25DCx37. Her corneal astigmatism was −1.25DCx74. Ophthalmic examination disclosed a severely tilted single-piece posterior chamber IOL in the capsular bag. The inferior portion of the optic was tilted posteriorly because of a twisted and malpositioned haptic. The patient underwent remedial surgery to untwist and reposition the IOL haptic which led to immediate improvement of the IOL position. Her uncorrected VA improved to 6/12−2 correctable with pinhole to 12+1 with an autorefraction of +0.25DS/−2.00DCx74 on the first postoperative day. One month postoperatively, her best-corrected VA was 6/12 with a refraction of +0.50DS/−2.50DCx82. Her final vision was limited by myopic macular degeneration.
Interviewer biases in medical survey data: The example of blood pressure measurements
Authors: Geldsetzer Pascal , Chang Andrew Young , Meijer Erik , Sudharsanan Nikkil , Charu Vivek , Kramlinger Peter , Haarburger Richard 
Published: March 2024

Abstract
Health agencies rely upon survey-based physical measures to estimate the prevalence of key global health indicators such as hypertension. Such measures are usually collected by nonhealthcare worker personnel and are potentially subject to measurement error due to variations in interviewer technique and setting, termed “interviewer effects.” In the context of physical measurements, particularly in low- and middle-income countries, interviewer-induced biases have not yet been examined. Using blood pressure as a case study, we aimed to determine the relative contribution of interviewer effects on the total variance of blood pressure measurements in three large nationally representative health surveys from the Global South. We utilized 169,681 observations between 2008 and 2019 from three health surveys (Indonesia Family Life Survey, National Income Dynamics Study of South Africa, and Longitudinal Aging Study in India). In a linear mixed model, we modeled systolic blood pressure as a continuous dependent variable and interviewer effects as random effects alongside individual factors as covariates. To quantify the interviewer effect-induced uncertainty in hypertension prevalence, we utilized a bootstrap approach comparing subsamples of observed blood pressure measurements to their adjusted counterparts. Our analysis revealed that the proportion of variation contributed by interviewers to blood pressure measurements was statistically significant but small: ∼0.24−−2.2% depending on the cohort. Thus, hypertension prevalence estimates were not substantially impacted at national scales. However, individual extreme interviewers could account for measurement divergences as high as 12%. Thus, highly biased interviewers could have important impacts on hypertension estimates at the subdistrict level.
Functional bio-inspired hybrid fliers with separated ring and leading edge vortices
Authors: Kim Jin-Tae , Yoon Hong-Joon , Cheng Shyuan , Liu Fei , Kang Soohyeon , Paudel Shashwot , Cho Donghwi , Luan Haiwen , Lee Minkyu , Jeong Gooyoon , Park Jaehong , Huang Yu-Ting , Lee Su Eon , Cho Min , Lee Geonhee , Han Mengdi , Kim Bong Hoon , Yan Jinhui , Park Yoonseok , Jung Sunghwan , Chamorro Leonardo P , Rogers John A 
Published: March 2024

Abstract
Recent advances in passive flying systems inspired by wind-dispersed seeds contribute to increasing interest in their use for remote sensing applications across large spatial domains in the Lagrangian frame of reference. These concepts create possibilities for developing and studying structures with performance characteristics and operating mechanisms that lie beyond those found in nature. Here, we demonstrate a hybrid flier system, fabricated through a process of controlled buckling, to yield unusual geometries optimized for flight. Specifically, these constructs simultaneously exploit distinct fluid phenomena, including separated vortex rings from features that resemble those of dandelion seeds and the leading-edge vortices derived from behaviors of maple seeds. Advanced experimental measurements and computational simulations of the aerodynamics and induced flow physics of these hybrid fliers establish a concise, scalable analytical framework for understanding their flight mechanisms. Demonstrations with functional payloads in various forms, including bioresorbable, colorimetric, gas-sensing, and light-emitting platforms, illustrate examples with diverse capabilities in sensing and tracking.
Fibroblast growth factor 7 protects osteoblasts against oxidative damage through targeting mitochondria
Authors: Liu Xiaoyu , Hu Xuchen , Niu Chenguang , Yang Yueyi , Huang Zhengwei , Xie Jing 
Published: March 2024

AbstractThe pathophysiology of osteoporosis is significantly influenced by the impaired functioning of osteoblasts, which is particularly caused by oxidative stress. Nevertheless, the underlying mechanisms responsible for this phenomenon are still not well understood. The objective of this study was to elucidate the impact of fibroblast growth factor 7 (FGF7) on the behavior of osteoblasts under conditions of oxidative stress. The osteoblast‐like MC3T3 cells were pretreated with recombinant FGF7 in the presence of oxidative stress induced by hydrogen peroxide (H2O2). We first provided the evidence that the endogenous FGF7 was significantly increased in osteoblasts in response to the increased H2O2 levels. Recombined FGF7 demonstrated a remarkable capacity to resist the detrimental effects of H2O2‐induced oxidative stress, including the increase in cell apoptosis, decrease in osteoblast viability, and impairment in osteogenic differentiation capacity, on osteoblasts. Furthermore, we extensively explored the mechanism underlying these protective effects and discovered a remarkable modulation of reactive oxygen species (ROS) homeostasis in H2O2‐treated cells following the pronounced expression of FGF7, which significantly differed from the control group. Additionally, we observed that FGF7 exerted partial preservation on both the morphology and function of mitochondria when exposed to oxidative stress conditions. Furthermore, FGF7 exhibited the ability to enhance the activation of the p38/MAPK signaling pathway while concurrently suppressing the JNK/MAPK signaling pathway in response to oxidative stress. These results underscore the promising role and underlying mechanisms of FGF7 in preserving osteoblast homeostasis in the face of oxidative stress.
CL‐11 circulates in serum as functionally distinct isoforms
Authors: Sutta Adrian , Leemans Nelia Nina , Ploug Michael , Rosbjerg Anne , del Agua Villa Christian , Pérez‐Alós Laura , Cyranka Leon , Vincek Adam S. , de Garay Tomás , Rivera Keith , Bayarri‐Olmos Rafael 
Published: March 2024

AbstractCollectin‐11 (CL‐11) is a pattern recognition molecule of the lectin pathway capable of interacting with collectin‐10 (CL‐10) and the MASPs to activate the complement cascade. Alternative splicing of the COLEC11 gene gives rise to two different isoforms found in serum (A and D). These isoforms vary in the length of their collagen‐like region, which is involved in the stabilization of the trimeric subunit and the interaction with the MASPs. Here we aim at elucidating the biological differences of naturally occurring CL‐11 isoforms A and D. We produced recombinant CL‐11 as independent isoforms (CL‐11A and CL‐11D) and together with CL‐10 (CL‐10/11A, CL‐10/11D). Both CL‐11 isoforms associated with CL‐10, but CL‐11D did so to a lesser extent. CL‐10/11 heterocomplexes were composed of trimeric subunits of CL‐10 and CL‐11, as opposed to CL‐10 and CL‐11 homotrimers. Heterocomplexes were more stable and migrated with higher apparent molecular weights. Immunoprecipitation of serum CL‐11 and subsequent mass spectrometry analysis confirmed that native CL‐11 circulates in the form of CL‐10/11 heterocomplexes that associate with MASP‐1, and MASP‐3, but not necessarily MASP‐2. Despite a shorter collagen region, CL‐11D was capable to bind to the MASPs, suggesting that the missing exon 4 is not required for MASP association CL‐11D had a reduced ligand binding compared to full‐length CL‐11A. Based on its reduced ability to oligomerize, form CL‐10/11 heterocomplexes, and bind to ligands, we hypothesize that CL‐11D may have a limited complement activation potential compared to full‐length CL‐11A.
The effects of virtual reality neuroscience-based therapy on clinical and neuroimaging outcomes in patients with chronic back pain: a randomized clinical trial
Authors: Čeko Marta , Baeuerle Tassilo , Webster Lynn , Wager Tor D. , Lumley Mark A. 
Published: March 2024

Abstract
Chronic pain remains poorly managed. The integration of immersive technologies (ie, virtual reality [VR]) with neuroscience-based principles may provide effective pain treatment by targeting cognitive and affective neural processes that maintain pain and therefore potentially changing neurobiological circuits associated with pain chronification and amplification. We tested the effectiveness of a novel VR neuroscience-based therapy (VRNT) to improve pain-related outcomes in n = 31 participants with chronic back pain, evaluated against usual care (waitlist control; n = 30) in a 2-arm randomized clinical trial (NCT04468074
). We also conducted pre-treatment and post-treatment MRI to test whether VRNT affects brain networks previously linked to chronic pain and treatment effects. Compared with the control condition, VRNT led to significantly reduced pain intensity (g = 0.63) and pain interference (g = 0.84) at post-treatment vs pre-treatment, with effects persisting at 2-week follow-up. These improvements were partially mediated by reduced kinesiophobia and pain catastrophizing. Several secondary clinical outcomes were also improved by VRNT, including disability, quality of life, sleep, and fatigue. In addition, VRNT was associated with increases in dorsomedial prefrontal functional connectivity with the superior somatomotor, anterior prefrontal and visual cortices, and decreased white matter fractional anisotropy in the corpus callosum adjacent to the anterior cingulate, relative to the control condition. Thus, VRNT showed preliminary efficacy in significantly reducing pain and improving overall functioning, possibly through changes in somatosensory and prefrontal brain networks.
Normothermic regional perfusion procurement for abdominal organ donors: techniques and troubleshooting
Authors: Silpe Stephanie , Martinez Eric , Wall Anji 
Published: March 2024

Purpose of review
Normothermic regional perfusion (NRP) is a novel procurement technique for donation after circulatory death (DCD) in the United States. It was pioneered by cardiothoracic surgery programs and is now being applied to abdominal-only organ donors by abdominal transplant programs. Multiple technical approaches can be used for abdominal-only NRP DCD donors and this review describes these techniques.

Recent findings
NRP has been associated with higher utilization of organs, particularly liver and heart grafts, from DCD donors and with better recipient outcomes. There are lower rates of delayed graft function in kidney transplant recipients and lower rates of ischemic cholangiopathy in liver transplant recipients. These benefits are driving increased interest from abdominal transplant programs in using NRP for DCD procurements.

Summary
This paper describes the technical aspects of NRP DCD that allow for maximization of its use based on different donor and policy characteristics.
Catastrophic skin necrosis after total knee arthroplasty: a case report and review of the literature
Authors: Hoveidaei Amir Human , Zafari Hamidreza , Mirghaderi Peyman , Ghadimi Ehsan , Mortazavi SM Javad 
Published: March 2024

Introduction and importance:
There have been few cases of post total knee arthroplasty (TKA) skin necrosis reported. Here, the authors present our patient with skin necrosis post TKA on account of its extreme rarity, considerable risk factors, and importance of its treatment

Case:
This is a cautionary report on the rule of including previous single longitudinal incision in surgical approach. The authors included previous medial incision in ours and performed arthroplasty through medial parapatellar incisions. After noticing skin necrosis in front of patella, reoperation including flap and skin graft was done, leading to complete recovery.

Clinical discussion:
While skin necrosis post TKA is not common, it can be present in high-risk patients who should be considered for a decrease in their risk factors. Preoperatively, underlying diseases should be under control. Intraoperation risk factors, in particular incision selection, and considerations about lateral retinacular release are important

Conclusion:
A balance must be achieved between the ability to expose the knee through a prior incision and avoiding extensive undermining of the subcutaneous flaps in patients with previous knee surgery. It may be a better approach to ignore medial incisions and use the classic midline incision.
Cytarabine-induced peripheral neuropathy in a young patient with acute myeloid leukemia: a case report
Authors: Karki Kshitiz , Adhikari Sugat , Shrestha Suraj , Bhandari Jenish , Baral Bidisha , Baral Aastha 
Published: March 2024

Introduction and importance:
Cytarabine, a pyrimidine analogue, is commonly used to treat multiple haematological conditions, such as acute leukaemias and lymphomas. One of the rare and less reported complications of cytarabine is peripheral neuropathy, in which peripheral nerves are damaged, often causing weakness, numbness, and pain, usually in the hands and feet.

Case presentation:
The authors report the case of a 17-year-old male who developed a gradual onset of weakness and sensory loss in all four limbs during treatment with a conventional dose of cytarabine for acute myeloid leukaemia. Cytarabine was discontinued after the development of symptoms, and his motor and sensory functions gradually improved over the course of 3 months.

Clinical discussion:
Alongside some well-known side effects of cytarabine, including bone marrow suppression, cerebellar syndrome, and cardiotoxicity, peripheral neuropathy is one of the uncommon side effects of cytarabine. Diagnosis includes identifying and grading the severity of chemotherapy-induced peripheral neuropathy (CIPN) through clinical assessment and nerve conduction studies. Management includes withdrawing the chemotherapeutic agent and supportive treatment with drugs such as duloxetine. Recent studies also favour the use of acupuncture and sensorimotor-based exercise intervention for the management of CIPN.

Methods:
This case report has been prepared in line with the SCARE 2023 criteria.

Conclusion:
Although rare, even a conventional dosage of cytarabine can cause peripheral neuropathy, and routine neuromuscular examinations can help in the early diagnosis and intervention to limit further progression and reverse the course of the disease.
A recurrence odontogenic keratocyst formation of mandible with distinctive features: a case report
Authors: Ali Mhammad , Ahmad Karam , Salloum Rabab , Atieh Amjad , Khalil Abdul-Karim 
Published: March 2024

Introduction and importance:
Odontogenic keratocyst (OKC) is a distinctive form of developmental odontogenic cyst that deserves special consideration because of its specific clinical behaviour and histopathologic features. The clinical and radiographic features of OKC are indefinite; while some may be associated with pain, swelling or drainage, most of them are asymptomatic. This case reports rare radiographic and histopathological features of recurrence OKC.

Case presentation:
A 47-years-old male patient presented with a main complaint of a painful mass in the oral cavity with a history of previous lesions that occurred in the posterior portion of the mandible related to extraction of impacted third molar. The oral examination revealed a swelling in the molar region of the right mandible with lingual plate expansion. The radiographic and histopathologic were consistent with the diagnosis of OKC. Consequently, the lesion was surgically removed, and no clinical or radiological recurrence was observed during the 8-month postoperative follow-up.

Clinical discussion
This case explained the clinical differences between OKC and other lesions and highlights the distinctive radiologic and microscopic features that a conflict with previous studies concerning the symptoms that may related to naevoid basal cell carcinoma syndrome, and revealed the proper treatment depending on the recurrence appearance and the treatment methods that used previously.

Conclusions
This case highlights a rare multilocular appearance of recurrent OKC in the mandible with no naevoid basal cell carcinoma syndrome related, supports the marginal resection as an effective procedure in the management of recurrent OKCs cases.