bluuebunny/crossref_metadata_2025_split huggingface dataset:
Durchlässigkeitsversuche an teilgesättigtem, gefrorenem Sand und Kies
Authors: Vrettos Christos , Seibel Elisabeth , Günther Ronald 
Published: March 2024

AbstractBei Anwendung des Gefrierverfahrens wird der gefrorene, wassergesättigte Boden als praktisch undurchlässig angenommen. Im Falle einer initialen Teilsättigung ist dies jedoch nicht sinnvoll. Im Rahmen einer Pilotstudie wurden diesbezüglich im Labor Durchlässigkeitsversuche an rolligen, locker gelagerten, teilgesättigten, gefrorenen Bodenproben durchgeführt. Als Durchflussmedium wurde ein Mineralöl verwendet. Da hierzu keine standardisierte Apparatur vorhanden ist, mussten geeignete Versuchstechniken und Auswertungsprozeduren neu konzipiert werden. Die Durchlässigkeit des ungefrorenen vollgesättigten Ausgangsbodens wurde als Referenzwert ebenfalls bestimmt. Es zeigte sich, dass die untersuchten teilgesättigten Böden wegen der lockeren Lagerung und des niedrigen Sättigungsgrades eine nennenswerte Durchlässigkeit aufweisen, die der Größenordnung nach den Werten der zugehörigen wassergesättigten ungefrorenen Böden entspricht.
Manganese‐Mediated Synthesis of NHC‐Phosphine Ligand Precursors
Authors: Willot Jérémy , Fatima Sana , Duhayon Carine , Lugan Noël , Canac Yves , Valyaev Dmitry A. 
Published: March 2024

AbstractAlkylation of N‐substituted imidazoles ImR’ (R’=2,4,6‐trimethylphenyl, 2,6‐diisopropylphenyl, 1‐adamantyl) with Mn(I) methylenephosphonium complexes [Cp(CO)2Mn(η2‐P,C‐R2P=C(H)Ph)](BF4) (PR2=PPh2, PCy2, trans‐PC(H)PhCH2CH2C (H)Ph) followed by photochemical demetallation afforded a series of bidentate NHC‐phosphine ligand precursors [R2PC(H)PhImR’](BF4) in moderate to good yield. The same strategy was successfully applied to N‐functionalized imidazoles ImL (L=2‐pyridyl, CH2SMe, CH2ImMe) to afford selectively NHC core pincer pre‐ligands featuring phosphine/thioether, phosphine/NHC and phosphine/pyridine side arms. For PCy2 derivatives, free NHCs in both bidentate and pincer series generated by deprotonation of the corresponding cationic precursors were shown to be persistent at room temperature.
Research on an optimal operation model for cascade pumping stations based on simulations
Authors: Zheng Xinrong , Gao Zhanyi , Yang Peiling , Chen Mengting 
Published: March 2024

AbstractCascade pumping stations (CPS) consume a large amount of energy every year in lifting districts. To obtain a reasonable and feasible operation scheme for CPS, this paper proposes an optimal operation model for CPS based on simulations. A one‐dimensional unsteady flow model of open canals was coupled with the optimal operation model of CPS, and an energy‐dominated optimization was proposed with the water level of the inlet pool as the coordinated variable. The optimization model was solved by using the catch‐up method and the nondominated sorted genetic algorithm II (NSGA‐II). The optimal operation method was validated and implemented in the first‐stage and second‐stage pumping stations of the Zuncun Irrigation Project by lifting water from the Yellow River in Shanxi province. The results showed that the proposed optimization model can reduce the energy consumption of the CPS by 4% compared with the actual operation. In addition, the optimal operation model of the CPS coupled with simulation can realize the dynamic balance of flow by stabilizing the inlet pool level to operate within a safe range. The energy consumption of the CPS can be reduced by keeping the water level of the intake pool as high a level as possible.
On the physical layer security performance of full‐duplex cooperative NOMA system with multiple eavesdroppers, imperfect SIC and hardware imperfections
Authors: Nimi T. , Babu A. V. 
Published: March 2024

AbstractIn this letter, we propose a control jammer‐assisted framework for improving the physical layer security (PLS) of full‐duplex (FD) ‐ cooperative non‐orthogonal multiple access (FD‐CNOMA) network. We derive analytical expressions for the secrecy outage probabilities (SOPs) of the users for the jammer‐assisted and the no‐jammer scenarios, considering multiple non‐colluding eavesdroppers, residual hardware impairments and imperfect successive interference cancellation conditions. It is demonstrated that the proposed jammer‐assisted framework provides significant reduction of the SOPs experienced by the downlink users in FD‐CNOMA network.
Cardioprotective effects of p‐coumaric acid on tachycardia, inflammation, ion pump dysfunction, and electrolyte imbalance in isoproterenol‐induced experimental myocardial infarction
Authors: Ponnian Stanely Mainzen Prince , Stanely Shervin Prince , Roy Abhro Jyoti 
Published: March 2024

AbstractCardiovascular diseases cause a large number of deaths throughout the world. No research was conducted earlier on p‐coumaric acid's effect on tachycardia, inflammation, ion pump dysfunction, and electrolyte imbalance. Hence, we appraised the above‐said parameters in isoproterenol‐induced myocardial infarcted rats. This investigation included 24 male albino Wistar rats in 4 groups. Normal control Group 1, p‐coumaric acid (8 mg/kg body weight) alone treated Group 2, Isoproterenol (100 mg/kg body weight) induced myocardial infarcted Group 3, p‐coumaric acid (8 mg/kg body weight) pretreated isoproterenol (100 mg/kg body weight) induced Group 4. After 1 day of the last dose of isoproterenol injection (day 10), rats were killed and blood and heart were taken and inflammatory markers, lipid peroxidation, nonenzymatic antioxidants, ion pumps, and electrolytes were measured. The heart rate, serum cardiac troponin‐T, serum/plasma inflammatory markers, and heart proinflammatory cytokines were raised in isoproterenol‐induced rats. Isoproterenol also enhanced plasma lipid peroxidation, lessened plasma nonenzymatic antioxidants, and altered heart ion pumps and serum and heart electrolytes. In this study, p‐coumaric acid pretreatment orally for 7 days to isoproterenol‐induced myocardial infarcted rats prevented changes in the above‐cited parameters. p‐Coumaric acid's anti‐tachycardial, anti‐inflammatory, anti‐ion pump dysfunction and anti‐electrolyte imbalance properties are the mechanisms for these cardioprotective effects.
Intergenerational transmission of genetic risk for hyperactivity and inattention. Direct genetic transmission or genetic nurture?
Authors: Voronin Ivan , Ouellet‐Morin Isabelle , Petitclerc Amélie , Morneau‐Vaillancourt Geneviève , Brendgen Mara , Dione Ginette , Vitaro Frank , Boivin Michel 
Published: March 2024

AbstractBackgroundHyperactivity and inattention, the symptoms of ADHD, are marked by high levels of heritability and intergenerational transmission. Two distinct pathways of genetic intergenerational transmission are distinguished: direct genetic transmission when parental genetic variants are passed to the child's genome and genetic nurture when the parental genetic background contributes to the child's outcomes through rearing environment. This study assessed genetic contributions to hyperactivity and inattention in childhood through these transmission pathways.MethodsThe sample included 415 families from the Quebec Newborn Twin Study. Twins' hyperactivity and inattention were assessed in early childhood by parents and in primary school by teachers. The polygenic scores for ADHD (ADHD‐PGS) and educational attainment (EA‐PGS) were computed from twins' and parents' genotypes. A model of intergenerational transmission was developed to estimate (1) the contributions of parents' and children's PGS to the twins' ADHD symptoms and (2) whether these variances were explained by genetic transmission and/or genetic nurture.ResultsADHD‐PGS explained up to 1.6% of the variance of hyperactivity and inattention in early childhood and primary school. EA‐PGS predicted ADHD symptoms at both ages, explaining up to 1.6% of the variance in early childhood and up to 5.5% in primary school. Genetic transmission was the only significant transmission pathway of both PGS. The genetic nurture channeled through EA‐PGS explained up to 3.2% of the variance of inattention in primary school but this association was non‐significant.ConclusionsGenetic propensities to ADHD and education predicted ADHD symptoms in childhood, especially in primary school. Its intergenerational transmission was driven primarily by genetic variants passed to the child, rather than by environmentally mediated parental genetic effects. The model developed in this study can be leveraged in future research to investigate genetic transmission and genetic nurture while accounting for parental assortative mating.
Synthesis of Stable Isotope, Tritiated, and Carbon‐14 Labeled Balcinrenone
Authors: Bergare Jonas , Bailey Christopher , Sörensen Henrik , Grönberg Gunnar , Broberg Karl , Berglund Monica , Grecu Tudor , Sanchez Carolina , Emtenäs Hans , Bragg Ryan A. , Elmore Charles S. 
Published: March 2024

ABSTRACTAs part of a medicinal chemistry program aimed at discovering a mineralocorticoid receptor modulator for treatment of kidney and cardiovascular indications, multiple labeled versions of the lead compound, balcinrenone (AZD9977), were prepared. Four stable isotope labeled versions of the compound were prepared for clinical bioanalysis and biological investigations. Three of these stable isotope labeled compounds were tritiated as well as the parent for biology applications and DMPK investigations. They were prepared using a standard iodination–tritiodehalogentation approach. Finally, AZD9977 was prepared in carbon‐14 labeled form for preclinical and clinical applications.
Comparative three‐dimensional jaw muscle anatomy of marsupial carnivores (Dasyurus spp.) and the termite‐eating numbat (Myrmecobius fasciatus)
Authors: Thomas Vanessa J. , Shaw Jeremy , Tay Natasha , Warburton Natalie M. 
Published: March 2024

AbstractAmong marsupials, the endangered numbat (Myrmecobius fasciatus) is the only obligate myrmecophage with a diet comprised strictly of termites. Like many other specialised myrmecophagous mammals, numbats have a gracile and highly specialised skull morphology with an elongated rostrum and small braincase. Myrmecobiidae is one of four taxonomic families within the Australasian marsupial order Dasyuromorphia, and to date, the muscular anatomy of any member of this group is relatively poorly known. We utilised microdissection and contrast‐enhanced microcomputed tomography scanning to provide the first comprehensive qualitative and quantitative descriptions of jaw muscle anatomy in numbats and quolls (Dasuyrus species). The arrangement of the jaw muscles across these species was conservative, both in gross anatomy and muscle proportions, corresponding to a ‘generalised’ mammalian pattern. In contrast to Dasyurus, the jaw muscles of the numbat were greatly reduced. Many aspects of the muscle anatomy of the numbat were similar to patterns reported in other myrmecophagous species, particularly a greatly reduced temporalis muscle. Unusually, the digastric muscle in the numbat was comprised of a single, large anterior belly while the posterior belly was absent. We propose that the enlarged anterior belly of the digastric may be linked to jaw stabilisation and coordination of tongue movements during feeding. The lateral insertion and fascial connection of the digastric to the tongue in numbats may also aid in distributing stress evenly across the jaw and minimise muscle fatigue. The muscle descriptions and three‐dimensional models provided in this study will facilitate further analysis of musculoskeletal adaptation and evolution within the Dasyuromorphia.
Relative Mediastinal Displacement Index (RMDI): A Prenatal MRI Indicator of Adverse Events in Fetuses With Isolated Left Congenital Diaphragmatic Hernia
Authors: Wu Fan , Chen Yonghao , Zhang Xin , Li Yuchao , Chen Zhaoji , Liu Zhenqing , Dai Wangchun , Yang Chaoxiang , Liu Hongsheng 
Published: March 2024

BackgroundExtracorporeal membrane oxygenation (ECMO), has partly improved congenital diaphragmatic hernia (CDH) outcomes, yet the overall morbidity and mortality remain high. Existing prenatal indicators for CDH fetuses are operator‐dependent, time‐consuming, or less accurate, a new simple and accurate indicator to indicate adverse events in CDH patients is needed.PurposeTo propose and assess the association of a new MRI parameter, the relative mediastinal displacement index (RMDI), with adverse events including in‐hospital deaths or the need for ECMO in fetuses with isolated left CDH (iLCDH).Study TypeRetrospective analysis.SubjectsOne hundred thirty‐nine fetuses were included in the iLCDH group (24 with adverse events and 115 without) and 257 fetuses were included in the control group from two centers in Guangzhou.Field Strength/Sequence3.0 T, T2WI‐TRUFI; 1.5 T, T2WI‐FIESTA.AssessmentThree operators independently measured the , , and DH on the axial images. The calculation formula of the RMDI was ( + )/DH.Statistical TestsThe independent sample t test, Mann–Whitney U test, Chi‐square test, Chi‐square test continuity correction, Fisher's test, linear regression analysis, logistic regression analysis, intraclass correlation coefficient, receiver operating characteristic curve analysis, and Delong test. A P value <0.05 was considered statistically significant.ResultsThe RMDI did not change with gestational age in the iLCDH group (with [P = 0.189] and without [P = 0.567] adverse events) and the control group (P = 0.876). There were significant differences in RMDI between the iLCDH group (0.89 [0.65, 1.00]) and the control group (−0.23 [−0.34, −0.16]). In the iLCDH group, RMDI was the only indicator left for indicating adverse events, and the best cutoff value was 1.105. Moreover, there was a significant difference in diagnostic accuracy between the RMDI (AUC = 0.900) and MSA (AUC = 0.820), LHR (AUC = 0.753), o/e LHR (AUC = 0.709), and o/e TFLV (AUC = 0.728), respectively.Data ConclusionThe RMDI is expected to be a simple and accurate tool for indicating adverse events in fetuses with iLCDH.Evidence Level4Technical EfficacyStage 1
Should we use risk selection tests for HPV 16 and/or 18 positive cases: Comparison of p16/Ki67 and cytology
Authors: Mazurec Karolina , Trzeszcz Martyna , Mazurec Maciej , Streb Joanna , Halon Agnieszka , Jach Robert 
Published: March 2024

AbstractMajor screening abnormalities in precolposcopic stage are tests results that imply direct referral to colposcopy (and/or expedited treatment) without performing additional high‐grade squamous intraepithelial lesions or worse (HSIL+) risk selection testing. Currently, both clinically validated HSIL+ risk selection tests, reflex cytology and reflex p16/Ki67 dual staining (DS), are being compared for use in primary human papillomavirus (HPV)‐based screening to avoid possible overtreatment, but there is still no sufficient data available for their performance. Among 30 066 liquid‐based cervical cancer screening tests results, a group of 332 women was selected with available high‐risk types of HPV tests results with 16/18 limited genotyping, liquid‐based cytology, DS, and histology results from standardized colposcopy with biopsy. In HPV 16/18+ cases, three triage approaches were retrospectively analyzed. Predictive values for detection of HSIL+ were calculated and number of colposcopies required in each strategy. Both triage models with DS used (reflex cytology followed by DS, and reflex DS alone in all cases) had significantly higher positive predictive value for HSIL+ than strategy with reflex cytology alone (44.2%/45.7% vs. 28.3%; p < 0.0001). In models with DS, less colposcopies were required (95/92 vs. 152) and less colposcopies were needed per HSIL+ detection (2.26/2.19 vs. 3.54). Only one HSIL+ case was missed in both triage models with DS incorporation. p16/Ki67 dual‐stain may be an effective, alone or combined with cytology, triage test to detect HSIL+ in patients with major screening abnormalities in primary HPV‐based cervical cancer screening. Performing cytology as the first triage test improves the strategy by enabling referrals to expedited treatment in selected cases.
Effect of a group logotherapeutic program for older adults on mental health indicators
Authors: Humer Elke , Kisler Ida‐Maria , Bach Doris , Schimböck Wolfgang , Pieh Christoph , Probst Thomas 
Published: March 2024

AbstractThe study aimed to evaluate a logotherapeutic program for its potential to improve mental well‐being in the elderly. Group logotherapy programs comprising eight sessions were provided to 44 older adults. Participants completed baseline, postintervention, and follow‐up questionnaires assessing mental well‐being, self‐esteem, life satisfaction, meaning in life, and psychological distress. The logotherapeutic program did not affect outcome measures when analyzed for the total sample. Separate analyses by participants scoring below or above the respective thresholds at baseline revealed increased well‐being and self‐esteem and decreased symptoms of depression, anxiety, obsessive–compulsive disorders, and somatoform symptoms, but only in individuals who were already experiencing poor well‐being, poor self‐esteem, or some level of psychological distress before the intervention. Results suggest that the logotherapy‐based group program can be particularly effective for older adults who are already experiencing psychological distress or have lower self‐esteem.
Myelin figures from microbial glycolipid biosurfactant amphiphiles
Authors: Roy Debdyuti , Chaleix Vincent , Parikh Atul N. , Baccile Niki 
Published: March 2024

AbstractMyelin figures (MFs)—cylindrical lyotropic liquid crystalline structures consisting of concentric arrays of bilayers and aqueous media—arise from the hydration of the bulk lamellar phase of many common amphiphiles. Prior efforts have concentrated on the formation, structure, and dynamics of myelin produced by phosphatidylcholine (PC)‐based amphiphiles. Here, we study the myelinization of glycolipid microbial amphiphiles, commonly addressed as biosurfactants, produced through the process of fermentation. The hydration characteristics (and phase diagrams) of these biological amphiphiles are atypical (and thus their capacity to form myelin) because unlike typical amphiphiles, their molecular structure is characterized by two hydrophilic groups (sugar, carboxylic acid) on both ends with a hydrophobic moiety in the middle. We tested three different glycolipid molecules: C18:1 sophorolipids and single‐glucose C18:1 and C18:0 glucolipids, all in their nonacetylated acidic form. Neither sophorolipids (too soluble) nor C18:0 glucolipids (too insoluble) displayed myelin growth at room temperature (RT, 25°C). The glucolipid C18:1 (G‐C18:1), on the other hand, showed dense myelin growth at RT below pH 7.0. Examining their growth rates, we find that they display a linear (L, myelin length; t, time) growth rate, suggesting ballistic growth, distinctly different from the dependence, characterizing diffusive growth such as what occurs in more conventional phospholipids. These results offer some insight into lipidic mesophases arising from a previously unexplored class of amphiphiles with potential applications in the field of drug delivery.
Effect of enzymatic hydrolysis of arabinoxylan on the quality of frozen dough during the subfreezing process
Authors: Zhu Nannan , Liu Yufen , Zhang Xing , Gao Haiyan , Zeng Jie , Yang Junjie , Song Jianguo , Li Xinjian , Zhao Tianxiang 
Published: March 2024

AbstractBACKGROUNDThe objective of this investigation was to examine the impact of enzymatic hydrolysis of arabinoxylan (AX) on frozen dough quality under subfreezing conditions. The dough was subjected to freezing at −40 °C for 2 h and then stored at −9, −12, and −18 °C for 15 days. The water loss, freezable water content, water migration, and microstructure of the dough were measured.RESULTSThe dough containing 0.8% cellulase enzymatically hydrolyzed AX (CAX) required the shortest duration when traversing the maximum ice‐crystal formation zone (6.5 min). The dough with xylanase enzymatically hydrolyzed AX (XAX) demonstrated a faster freezing rate than the dough with CAX. The inclusion of both XAX and CAX in the dough resulted in the lowest freezable water loss and reduced freezable water content and free‐water content levels, whereas the inclusion of xylanase‐cellulase combined with enzymatically hydrolyzed AX resulted in higher free‐water content levels. The textural properties of the subfreezing temperature dough were not significantly different from the dough stored at −18 °C and sometimes even approached or surpassed the quality observed in the control group rather than the dough stored at −18 °C. In addition, the gluten network structure remains well preserved in XAX‐ and CAX‐containing doughs with minimal starch damage.CONCLUSIONThe enzymatic hydrolysis of AX from wheat bran can be used as a useful additive to improve the quality of frozen dough. © 2024 Society of Chemical Industry.
Fatigue is associated with disease severity in adult patients with hidradenitis suppurativa
Authors: Chodziuk Astrid , Holgersen Nikolaj , Nielsen Valdemar W. , Thyssen Jacob P. , Egeberg Alexander , Thomsen Simon F. 
Published: March 2024

AbstractBackgroundPatients with hidradenitis suppurativa (HS) experience fatigue, but no studies have yet examined the association between HS severity and fatigue intensity.ObjectivesTo examine the possible association between HS severity and fatigue and identify fatigue subtypes present in patients with HS.MethodsAdult patients with HS participated in a survey assessing fatigue using the Multidimensional Fatigue Inventory‐20. Disease severity was determined by self‐report.ResultsData from 654 adult patients with HS were analysed and compared with 3,788 reference individuals from the general population. Total and subtype fatigue scores for patients with HS were significantly higher compared with the general population reference individuals and increased with higher HS severity, itch, pain, sleep, dermatology life quality index scores and lower socioeconomic status. The association between HS severity and increased fatigue scores remained statistically significant after adjustment for age, sex, and socioeconomic status.ConclusionsPatients with HS had a significantly higher fatigue score compared with the general population reference individuals in a severity‐dependent manner. A higher awareness of fatigue as a symptom in patients with HS is warranted.
Role of copper and zinc additives in the stiction phenomenon of automotive braking systems
Authors: Motta Michele , Iodice Valentina , Xicola Agusti Sin , Truccolo Alberto , Fedrizzi Lorenzo , Andreatta Francesco 
Published: March 2024

AbstractThe braking system of a motor vehicle is a multi‐material system, subjected to various aggressive conditions. Corrosion of the brake disc during stationary periods can determine the onset of a high adhesion force (stiction) capable of compromising the reliability of the braking system during vehicle motion. The purpose of this work is to study the effect of the introduction of Cu and Zn in the friction material composition. This effect was investigated through electrochemical measurements (electrochemical impedance spectroscopy, potentiodynamic polarization, and stiction tests), conducted using an electrochemical cell simulating the parking brake, complemented by the examination of the brake disc and pad surfaces and water absorption tests. The results suggest that porous components, like vermiculite, in the composite friction material led to high contact force. Moreover, 10 wt% of Cu in the friction material does not significantly affect its stiction behavior in our testing configuration. In contrast, 10 wt% Zn in the friction material significantly reduces the stiction propensity by acting with a complex synergistic mechanism combining physical and chemical shielding effects.