bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rice straw biochar mitigates metal stress in maize and assists in the phytoattenuation of a slag-contaminated soil
Authors: Veloso Venâncio Lima , Silva Fernando Bruno Vieira , Araújo Paula Renata Muniz , Paraizo Taciana Silva , Souza Edivan Rodrigues , Nascimento Clístenes Williams Araújo 
Published: April 2024

Abstract
Soils polluted by heavy metals soils pose a high risk to human health and must be remediated. Applying biochar to such soils can reduce metal bioavailability and phytotoxicity, improving phytoremediation techniques. This work aimed to assess the effects of rice straw biochar (RSB) on mitigating metal stress and accumulation of Si, Cd, Pb, and Zn in maize plants grown in soil contaminated by metallurgy slag. The soil in pots was amended with RSB rates equivalent to 0.0, 5.0, 10.0, 20.0, and 30.0 t ha-1 and grown with maize for 45 days. Chlorophyll fluorescence, photosynthetic pigment contents, and gas exchange parameters were evaluated as metal toxicity indicators. The RSB rates significantly increased Si uptake while reducing Cd, Pb, and Zn accumulation in maize shoots. The addition of 30.0 t ha-1 RSB promoted 18, 34, and 37% reductions for Zn, Cd, and Pb in the plants. Photosynthetic rate, transpiration, and stomatal conductance increased by 68%, 67%, and 55%, while chlorophyll a, b, and carotenoid contents increased by 77%, 57%, and 42%, correspondingly. Chlorophyll fluorescence measurements showed a linear and positive relationship between photosystem II energy consumption efficiency (Fv/Fm) and RSB rates. Applying RSB associated with maize cultivation can assist in the phytoattenuation of Cd, Pb, and Zn contamination in soils since RSB increases biomass and the plant's tolerance to metal stress.
Early expression of monomeric and oligomeric alpha-synuclein and tyrosine hydroxylase following intranigral injection of lipopolysaccharide
Authors: Lomeli-Lepe Alma Karen , López-Pérez Silvia Josefina , Castañeda-Cabral José Luis , Ureña-Guerrero Mónica E. 
Published: April 2024

Abstract
Background The insoluble tangles of alpha-synuclein (α-syn) protein in the nigrostriatal circuit, characteristic of synucleinopathy, originate from low molecular weight oligomers, whose appearance and dissemination are related to neuroinflammation. These oligomeric forms of α-syn are considered highly cytotoxic but transient, so knowing the timing in which they appear remains a challenge. Therefore, this study aimed to analyze the abundance of oligomeric forms of α-syn and tyrosine hydroxylase (TH) between 1 and 7 days after inducing neuroinflammation with lipopolysaccharide (LPS).Methods and Results LPS (2.5 µg/2.5 µL) was stereotaxically injected in the SN of adult male Wistar rats, which were sacrificed 3, 5 and 7 days after this intervention. The brains were processed for semi quantitative Western blot, along with brains from control and sham animals. Our results show an increased expression of α-syn monomer (15 kDa) only 3 days after LPS infusion, and the formation of 50 KDa and 60 kDa α-syn oligomers in the SN and STR between 3 and 7 days after LPS infusion. Furthermore, the presence of these oligomers was accompanied by a decrease in the expression of nigral TH.Conclusion These findings highlight the rapidity with which potentially toxic forms of α-syn appear in the nigrostriatal circuit after a neuroinflammatory challenge, in addition to allowing us to identify specific oligomers and a temporal relation with neurodegeneration of TH-positive cells. Knowledge of the timing and location in which these small oligomers appear is essential to developing therapeutic strategies to prevent its formation.
New Trichoderma Asperellum Multirecycled Biologic for Spring Soft Wheat Rhizosphere: Protecting From Diseases and Increasing Soil Suppressiveness in West Siberia Conditions
Authors: Titova Julia 
Published: April 2024

Abstract
Contemporary polyfunctional biologics using contributes to the soil suppressiveness increasing, improves the agroecosystems phytosanitary conditions and yields increases. The research goal was to biologically justify the new multirecycled biologic’s prototype based on Trichoderma asperellum T-36 in protecting spring soft wheat from diseases and increasing soil suppressiveness in West Siberia. The tasks were solved on the new multirecycled substrate-associated granular polyfunctional biologic (MSAPB, G) prototype developing; 2 years field trials data evaluating and statistically processing on phytoregulatory activity and field efficacy of prototype in spring soft wheat cultivation; total and induced soil suppressive activity estimating on natural and artificial infection backgrounds with T. asperellum T-36 involving. In 2 series field trials the prototype demonstrated phytoregulatory activity: biometric indices of wheat plants development under its influence reliably (p ≤ 0.05) 1.4 times exceeded the control ones. Biological efficacy against soil pathogens was 33–56, 41–59 %; in the development of leaf-stem infections 25–50, 30–98 % for template reference – Sternyphage, WP (wettable powder) and for MSAPB, G prototype respectively. From tube emergence to milk ripeness, the highest soil activity in rhizosphere under the prototype influence was reliably (p ≤ 0.01) 2 times higher than the control one. High total soil suppressiveness, as well as forming and strengthening of induced suppressiveness by protective biologics application in all phases of wheat plants development were shown. Successions were revealed in wheat holobiont development from 0 day up to vegetation end, caused by the absence of significant similarity in rhizosphere microbiota complexes in dynamics.
Psychosocial Predictors of Sleep Disturbances during COVID-19: differential contributions of demographic, psychological, pandemic-related factors to sleep health.
Authors: Varela Vasiliki , Giogkaraki Erasmia , Vlastos Dimitrios , Alzueta Elisabet , Perrin Paul B , Ramos-Usuga Daniela , Arango-Lasprilla Juan Carlos , Liozidou Athanasia 
Published: April 2024

Abstract

Aim: Since the declaration of COVID-19 as a Public Health Emergency of International Concern on January 30, 2020, the disease escalated into a global pandemic forcing governments around the world to impose measures that affected all aspects of life. Among other countries, Greece adopted social restriction, lockdowns, and quarantines to reduce transmission from person to person.
Subjects and Methods: This cross-sectional study aimed to investigate the impact of those measures on sleep health in a Greek adult sample. An online questionnaire collected data during from 650 participant.
Results: 60% of responders scored below the clinical cut-off on the RU-SATED, indicating they experienced poor sleep health. Better sleep health was reported with increased age and years of education. On the other hand, higher trauma-related distress, depression, anxiety and stress symptomatology were related to poorer sleep health. No gender differences were observed, and degree of compliance to pandemic restrictions did not influence sleep health. Hierarchical regression analysis indicated difficulty in securing enough/healthy food, testing positive for COVID-19, experiencing an increase in verbal arguments/conflicts at home and an increase in responsibilities were the strongest predictors of poor sleep heath.
Conclusions: Results highlight the importance of maintaining good sleep health as a pillar of general physical and mental health.
Enhancing pollutant removal efficiency in urban domestic wastewater treatment through the hybrid multi-soil-layering (MSL) system: A case study in Morocco
Authors: Kammoun Aya , Ouazzani Naaila , El Fels Abdelhafid El Alaoui , Hejjaj Abdessamad , Mandi Laila 
Published: April 2024

ABSTRACT

This paper evaluates the performance and potential of a full-scale hybrid multi-soil-layering (MSL) system for the treatment of domestic wastewater for landscape irrigation reuse. The system integrates a solar septic tank and sequential vertical flow MSL and horizontal flow MSL components with alternating layers of gravel and soil-based material. It operates at a hydraulic loading rate of 250 L/m2/day. Results show significant removal of pollutants and pathogens, including total suspended solids (TSS) (97%), chemical oxygen demand (COD) (88.57%), total phosphorus (TP) (79.93%), and total nitrogen (TN) (88.49%), along with significant reductions in fecal bacteria indicators (4.21 log for fecal coliforms and 3.90 log for fecal streptococci) and the pathogen Staphylococcus sp. (2.43 log). The principal component analysis confirms the effectiveness of the system in reducing the concentrations of NH4, COD, TP, PO4, fecal coliforms, fecal streptococci, and fecal staphylococci, thus supporting the reliability of the study. This work highlights the promising potential of the hybrid MSL technology for the treatment of domestic wastewater, especially in arid regions such as North Africa and the Middle East, to support efforts to protect the environment and facilitate the reuse of wastewater for landscape irrigation and agriculture.
Dor total nos pacientes em cuidados paliativos oncológicos: Percepção fenomenológica dos residentes de enfermagem
Authors: Pereira Regina Alves , Silva Rose Mary Costa Rosa Andrade , Pereira Eliane Ramos , Siqueira Alex de Azeredo , Frederico Conceição Grazielle Teixeira , Carneiro Eliane  Cristina da Silva Pinto 
Published: April 2024

O presente estudo tem como objetivo compreender a percepção fenomenológica dos residentes de enfermagem sobre a dor total na atenção paliativa oncológica, sob a ótica de Merleau-Ponty. Trata-se de uma pesquisa descritiva exploratória com abordagem qualitativa na percepção fenomenológica de Merleau-Ponty, realizada no setor de internação de uma Unidade Hospitalar de Cuidados Paliativos, pertencente a um Centro de Referência de Assistência de Alta Complexidade em Oncologia do Ministério da Saúde, localizado no Município do Rio de Janeiro, Brasil. Para a coleta de dados utilizou-se a entrevista semiestruturada e fenomenológica, no período de agosto a novembro de 2022. A amostra, composta por 20 residentes, foi por conveniência e realizada pelos critérios de saturação e redundância dos dados. As informações foram organizadas e analisadas seguindo o rigor metodológico de Amedeo Giorgi. Após a análise ancorada no referencial metodológico de Amedeo Giorge, emergiram quatro categorias, sendo uma delas: “Percebendo o significado e o sentido da vida ao analisar a Dor Total”, tendo como subcategorias: A percepção do sentido da vida ao trabalhar/lidar com a dor do ser e Influição da ausência do saber/compreensão sobre a Dor Total. Assim, a pesquisa mostrou as dificuldades encontradas pelos profissionais em formação dentro de uma unidade de cuidados paliativos, no que se refere a dor total. Faz-se necessário na rotina desses profissionais, desenvolver estratégias para ampliar saberes, com a finalidade de contribuir na formação e conhecimento constante dos membros da equipe de enfermagem.
Palavras-Chave: Cuidados Paliativos; Dor Intratável; Capacitação de Recursos Humanos em Saúde; Oncologia.
Ácido fólico no tratamento adjuvante de transtornos psiquiátricos: uma revisão integrativa
Authors: Sulzbach Damázio Louyse , Mandelli Michael 
Published: April 2024

Transtornos psiquiátricos são caracterizados por uma combinação de pensamentos, percepções, emoções e comportamento anormais, que também podem afetar as relações com outras pessoas.: Evidenciar através de uma revisão integrativa os resultados clínicos da suplementação de ácido fólico no tratamento de transtornos psiquiátricos. A terapia e o tratamento psiquiátrico são processos terapêuticos diferentes, mas que podem se complementar, devido à atenção especializada nos aspectos da mente e das emoções de um indivíduo. Com base nisso, este artigo teve como objetivo avaliar os efeitos do tratamento de ácido fólico no tratamento de transtornos psiquiátricos. Revisão integrativa da literatura realizada no período de setembro a outubro de 2023 nas bases de dados Pubmed, Lilacs, Medline e Scielo. Foi realizada uma busca pelos descritores em saúde determinados e foram selecionadas 10 produções científicas que atenderam os critérios de inclusão. Os resultados demonstrar que, apesar de alguns estudos apresentarem melhoras significativas, sugere-se mais estudos para que seja possível elucidar os efeitos benéficos, ou não, da suplementação de ácido fólico, para que assim possa ser utilizado como uma forma de terapia auxiliar para os transtornos psiquiátricos.
Plasma/Serum Proteomics based on Mass Spectrometry
Authors: Zhu Yiying 
Published: April 2024

Abstract:
Human blood is a window of physiology and disease. Examination of biomarkers in
blood is a common clinical procedure, which can be informative in diagnosis and prognosis of
diseases, and in evaluating treatment effectiveness. There is still a huge demand on new blood
biomarkers and assays for precision medicine nowadays, therefore plasma/serum proteomics has
attracted increasing attention in recent years. How to effectively proceed with the biomarker
discovery and clinical diagnostic assay development is a question raised to researchers who are
interested in this area. In this review, we comprehensively introduce the background and
advancement of technologies for blood proteomics, with a focus on mass spectrometry (MS).
Analyzing existing blood biomarkers and newly-built diagnostic assays based on MS can shed light
on developing new biomarkers and analytical methods. We summarize various protein analytes in
plasma/serum which include total proteome, protein post-translational modifications, and
extracellular vesicles, focusing on their corresponding sample preparation methods for MS analysis.
We propose screening multiple protein analytes in the same set of blood samples in order to increase
success rate for biomarker discovery. We also review the trends of MS techniques for blood tests
including sample preparation automation, and further provide our perspectives on their future
directions.
The Postoperative Effects of Anesthesia Exposure on Cognitive Decline in
Older Adults: A Narrative Review
Authors: Willoughby-Dudley Kathleen Angela , Darwin Marielle L. , Davalos Deana B. 
Published: April 2024

Background::
As modern medicine continues to make strides in effective surgical treatments,
we must also consider the critical impact of anesthesia on neuropsychological outcomes.
Recent evidence suggests that anesthesia exposure may be a risk factor for postoperative cognitive
decline and the eventual development of dementia.

Objectives::
To explore the vulnerability of the aging brain in the context of anesthesia exposure in
surgery, studies will be reviewed, and pertinent findings will be highlighted and explored to better
understand risks and possible factors that need to be considered when contemplating surgery.
Methods: A narrative review was conducted using a combination of MEDLINE and APA PsycINFO
databases to shed light on themes across studies assessing general trends regarding the influence
of anesthesia on postoperative cognitive decline.

Results::
A search of relevant literature identified 388 articles. Excluding results outside the parameters
of this study, the review includes quality assessments for 24 articles.

Conclusion::
While findings are inconclusive, suggestions for further investigation into the relationship
between anesthesia exposure and increased risk for postoperative cognitive decline are
discussed, in addition to factors that may allow for greater informed disclosure of potential risks
of anesthesia in older adults.
Hormonal Imbalance in Obesity and Arthritis: Points of Contact
Authors: Vijayan Sukanya , Margesan Thirumal 
Published: April 2024

Abstract:
Obesity is a growing global health crisis intricately connected to various chronic conditions,
including arthritis. This paper explores the intricate web of hormonal changes in the context
of obesity and their profound influence on the development and progression of arthritis. Hormones,
such as leptin, insulin, cortisol, and estrogen, all altered in obesity, play pivotal roles in inflammation,
cartilage degradation, mechanical stress, and pain associated with obesity-related
arthritis. Additionally, the mechanical stress placed on weight-bearing joints by excess body
weight accelerates joint wear and tear, contributing to arthritis. Genetic factors, shared biomarkers,
and pathways further link these conditions. Recognizing these connections is vital for healthcare
professionals and individuals facing the challenges of obesity and arthritis, offering insights
into strategies for prevention, management, and intervention. This comprehensive understanding
of the complex interplay between hormonal changes, obesity, and arthritis sheds light on multifaceted
mechanisms underlying this intricate relationship.
Lactate is Associated with Long-Term Mortality in Hospitalized Patients
with COVID-19: A Retrospective Cohort Study
Authors: Ebrahimi Pouyan , Fallah Farnaz , Pakdaman Kimia , Shirafkan Hoda , Abedi Seyed Hassan 
Published: April 2024

Introduction:
A recent pandemic caused by Coronavirus 2019 (COVID-19) caused mild
and severe systemic organ involvement that led to the death of enormous numbers of people. The
prevalence of the disease has declined over the past years, but concerns about upcoming mutations
remain. In this study, the relationship between lactate levels and mortality at different times was investigated.

Methods:
In the present retrospective study, 228 hospitalized patients with COVID-19 were included
according to the inclusion and exclusion criteria. A modified National Early Warning Score 2
(NEWS2) was used to determine the severity of the patients' conditions. Follow-up of patients, if
discharged alive, has been done from hospitalization until March, 2022. Data were analyzed using
SPSS version 22, and p < 0.05 was considered significant.

Results:
Lactate levels (2.88 ± 2.37 in the dead group versus 1.68 ± 1.33 in the living group) have a
significant relationship with mortality at hospitalization (p < 0.001). Furthermore, higher lactate levels during hospitalization (p < 0.001, HR = 2.960, 95%CI =4.255-2.58) and follow-up (p < 0.001, HR
= 2.960, 95%CI =4.255 to 2.58) increased the mortality risk ratio by more than two-fold.

Conclusion:
This study reported that initial lactate levels at admission predict COVID-19 patients'
mortality at hospitalization and follow-up. However, further research is needed in this area
Evaluation of diabetes patients' knowledge and practice levels about diabetic foot care
Authors: Shani Ali Oudah , Kaya Nedret Tekin 
Published: April 2024

Introduction. Diabetes is a very common public health problem. Diabetic foot is a complication of diabetes and can cause significant foot problems. Diabetic foot wounds are a significant problem with serious consequences for both patients and healthcare systems.
Aim. Our aim in this research was to determine the knowledge and practice levels of diabetic patients regarding diabetic foot care.
Materials and Methods. The research was conducted in a cross-sectional descriptive design. Research data were collected from April 2022 to July 2022. The sample was diabetic patients (n=200). A form was used to determine the sociodemographic characteristics of the patients and their knowledge and practice levels regarding diabetic foot care.
Results. Diabetic foot care knowledge level was found to be low in 60.5% of the patients. Additionally, it was determined that 62.5% of the patients had low diabetic foot application. A statistically significant difference was found between the patients' level of knowledge about diabetic foot and their gender, education level, profession, income, place of residence, and whether there is a health center or hospital close to where they live.A statistically significant difference was found between the patients' diabetic foot practice level and their level of education, profession and residence (p<0.05).
Conclusion. It was observed that the level of knowledge and practice regarding diabetic foot was low in most of the patients. Diabetic patients should be informed about foot problems and treatments when they apply to hospitals.
Rola i zadania pielęgniarki w opiece nad dzieckiem z rozpoznaną cukrzycą typu 1 - studium indywidualnego przypadku
Authors: Modracka Justyna 
Published: April 2024

Wstęp. Cukrzyca typu 1 jest współcześnie najczęstszą chorobą przewlekłą. Według badań liczba chorych z roku na rok ciągle wzrasta, a sama choroba stanowi wciąż zagadkę dla ówczesnych lekarzy.
Cel. Celem pracy jest wskazanie zadań pielęgniarki, sprawowanych wobec dziecka z rozpoznaną cukrzycą typu 1 oraz przedstawienie problemów pielęgnacyjnych, wynikających z choroby.
Prezentacja przypadku. Dziewczynka lat 8 została przyjęta do szpitala z powodu silnego bólu brzucha, wymiotów i osłabienia. Od około dwóch tygodni utrzymuję się u dziecka wzmożone pragnienie (polidypsja) i wielomocz (poliuria). Od kilku dni rodzice zaobserwowali u dziewczynki większą senność, nudności, osłabienie i utratę masy ciała o ok. 2 kg. Śluzówki jamy ustnej widocznie suche, wyczuwalny zapach acetonu (oddech Kussmaula). Na podstawie objawów klinicznych i wyników badań laboratoryjnych rozpoznano cukrzycę typu 1 powikłaną cukrzycową kwasicą ketonową. Rodzice okazują brak wiedzy na temat choroby i są bardzo zaniepokojeni stanem zdrowia swojego dziecka.
Wnioski. Pielęgniarka podczas opieki nad dzieckiem z rozpoznaną cukrzycą typu 1 zobowiązana jest do ciągłego monitorowanie podstawowych parametrów życiowych, dążenia do wyrównania stężenia glukozy we krwi, ciągłego jej sprawdzania oraz adekwatnego nawodnienia organizmu oraz stworzenia pozytywnej atmosfery.
Del malestar social a la enfermedad psicosocial. El papel de la integración comunitaria
Authors: Aguilar Medina Jose Iñigo 
Published: April 2024

El sentido común determina que la consulta a un terapeuta es signo de que el individuo padece una enfermedad mental, que ella incide en las relaciones sociales de las personas, que desordena tanto su comportamiento, como el ritmo cotidiano con el que desarrollan su vida y que deben ser atendidas como un problema individual. Al mismo tiempo, se advierte que en las últimas décadas se ha incrementado la demanda para obtener la atención terapéutica de un especialista en psicología o psiquiatría.En sentido opuesto al descrito, en este estudio se sostiene que la causa está en el modelo económico que impide que las personas hoy puedan establecer fuertes lazos comunitarios. Pérdida que, sin embargo, se compensa con la relación de tipo terapéutico, como concepto de vida y que se ocupa en tratar de remediar los procesos de la despersonalización de los individuos inducidos por la sociedad posmoderna. Por lo que al contrario de lo que el sentido común determina,el aumento de la atención psicológica no es una manifestación del incremento de las enfermedades mentales, sino que expresa una modificación cultural en la manera en que se construye la vida cotidiana al margen de la comunidad y no como un incremento de la enfermedad individual.
Pobreza y estrategias familiares: un estudio en la ciudad de Colima
Authors: Romero Plana Virginia 
Published: April 2024

El presente trabajo recoge apuntes muy particulares sobre cuáles son las condiciones en las que se desenvuelven cinco familias, catalogadas como “pobres”, en la ciudad de Colima. El enfoque cualitativo propició la realización de cinco estudios de caso en cuatro colonias de la zona sur y este de la capital: El Tívoli, Insurgentes, La Albarrada y San Rafael, ahondando en un análisis posterior que presentó cinco historias de vida familiares entretejidas. El foco de atención fueron las estrategias desarrolladas por los miembros de la familia, intra y extra-hogar, para afrontar la desigualdad sufrida. El fin último fue acercar a la sociedad a una realidad que día a día sufren muchas familias, y sensibilizar sobre la situación de exclusión y vulnerabilidad. Asimismo, en el espacio académico, se trazó una meta en el sentido de la discusión, reflexión y apropiación de conocimientos intrínsecos al ámbito de la pobreza que el Trabajo Social pudiera utilizar en pro de las intervenciones sociales acordes con las líneas de acción.