bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erythropoietin receptor signal is crucial for periodontal ligament stem cell-based tissue reconstruction in periodontal disease
Authors: Zakaria MHD. Fouad , Sonoda Soichiro , Kato Hiroki , Ma Lan , Uehara Norihisa , Kyumoto-Nakamura Yukari , Sharifa M. Majd , Yu Liting , Dai Lisha , Yamauchi-Tomoda Erika , Aijima Reona , Yamaza Haruyoshi , Nishimura Fusanori , Yamaza Takayoshi 
Published: March 2024

AbstractAlveolar bone loss caused by periodontal disease eventually leads to tooth loss. Periodontal ligament stem cells (PDLSCs) are the tissue-specific cells for maintaining and repairing the periodontal ligament, cementum, and alveolar bone. Here, we investigated the role of erythropoietin receptor (EPOR), which regulates the microenvironment-modulating function of mesenchymal stem cells, in PDLSC-based periodontal therapy. We isolated PDLSCs from patients with chronic periodontal disease and healthy donors, referred to as PD-PDLSCs and Cont-PDLSCs, respectively. PD-PDLSCs exhibited reduced potency of periodontal tissue regeneration and lower expression of EPOR compared to Cont-PDLSCs. EPOR-silencing suppressed the potency of Cont-PDLSCs mimicking PD-PDLSCs, whereas EPO-mediated EPOR activation rejuvenated the reduced potency of PD-PDLSCs. Furthermore, we locally transplanted EPOR-silenced and EPOR-activated PDLSCs into the gingiva around the teeth of ligament-induced periodontitis model mice and demonstrated that EPOR in PDLSCs participated in the regeneration of the periodontal ligament, cementum, and alveolar bone in the ligated teeth. The EPOR-mediated paracrine function of PDLSCs maintains periodontal immune suppression and bone metabolic balance via osteoclasts and osteoblasts in the periodontitis model mice. Taken together, these results suggest that EPOR signaling is crucial for PDLSC-based periodontal regeneration and paves the way for the development of novel options for periodontal therapy.
Increasing obstructive sleep apnea risk is associated with albuminuria in Korean adults: cross-sectional analysis
Authors: Chang Suk Won , Kang Ju Wan 
Published: March 2024

AbstractSeveral studies have shown an association between albuminuria and obstructive sleep apnea (OSA). However, studies on the relationship between the STOP-BANG questionnaire that can screen for OSA and microalbuminuria are still insufficient. Therefore, this study attempted to clarify the relationship between microalbuminuria and OSA risk using the STOP-BANG questionnaire in Korean adults. A total of 7478 participants (3289 men and 4189 women) aged over 40 were enrolled in the Korean National Health and Nutrition Examination Survey from 2019 to 2020. STOP-BANG questionnaire to screen OSA was obtained from subjects. The urinary albumin/creatinine ratio (ACR) and proteinuria were measured via a single dipstick to evaluate renal function. The high OSA risk group had a higher mean ACR value than the low OSA risk group (36.8 ± 172.2 vs 17.7 ± 82.5; P < 0.001). The proportion of subjects with values of 30 ≤ ACR < 300 mg/g (11.9% vs 6.1%; P < 0.001) and ACR > 300 mg/g (2.1% vs 0.7%; P < 0.001) was significantly higher in high OSA risk group. Multivariate logistic regression results confirmed that microalbuminuria (OR 1.279, 95% confidence interval (CI) 1.068–1.532, P = 0.008) was significantly correlated with high OSA risk. In addition, significant correlation with high OSA risk was also found in macroalbuminuria (OR 1.684, 95% CI 1.073–2.530, P = 0.022) and proteinuria (OR 1.355, 95% CI 1.030–1.783, P = 0.030). We confirmed a significant correlation between high OSA risk and albuminuria/proteinuria in Korean adults. Therefore, renal function evaluation is required in high OSA risk patients, and OSA diagnosis through PSG test and treatment is necessary.
RNA-binding proteins potentially regulate the alternative splicing of cell cycle-associated genes in proliferative diabetic retinopathy
Authors: Yang Ning , Zhang Ningzhi , Lu Guojing , Zeng Siyu , Xing Yiqiao , Du Lei 
Published: March 2024

AbstractRNA-binding proteins (RBPs) contribute to the pathogenesis of proliferative diabetic retinopathy (PDR) by regulating gene expression through alternative splicing events (ASEs). However, the RBPs differentially expressed in PDR and the underlying mechanisms remain unclear. Thus, this study aimed to identify the differentially expressed genes in the neovascular membranes (NVM) and retinas of patients with PDR. The public transcriptome dataset GSE102485 was downloaded from the Gene Expression Omnibus database, and samples of PDR and normal retinas were analyzed. A mouse model of oxygen-induced retinopathy was used to confirm the results. The top 20 RBPs were screened for co-expression with alternative splicing genes (ASGs). A total of 403 RBPs were abnormally expressed in the NVM and retina samples. Functional analysis demonstrated that the ASGs were enriched in cell cycle pathways. Cell cycle-associated ASEs and an RBP–AS regulatory network, including 15 RBPs and their regulated ASGs, were extracted. Splicing factor proline/glutamine rich (SFPQ), microtubule-associated protein 1 B (MAP1B), heat-shock protein 90-alpha (HSP90AA1), microtubule-actin crosslinking factor 1 (MACF1), and CyclinH (CCNH) expression remarkably differed in the mouse model. This study provides novel insights into the RBP–AS interaction network in PDR and for developing screening and treatment options to prevent diabetic retinopathy-related blindness.
How Toddlers Use Core and Fringe Vocabulary: What's in an Utterance?
Authors: Binger Cathy , Magallanes Priscilla , Miguel Vanessa San , Harrington Nancy , Hahs-Vaughn Debbie 
Published: March 2024

Purpose:
Selecting vocabulary for preliterate individuals who use augmentative and alternative communication presents multiple challenges, as the number of symbols provided must be balanced with cognitive, motoric, and other needs. Prioritizing certain types of vocabulary thus becomes a necessity. For example, prioritizing core vocabulary—that is, words that are commonly used across a group of people and contexts—is a common practice that attempts to address some of these issues. However, most core vocabulary research to date has narrowly focused on individual word counts, ignoring other critical aspects of language development such as how vocabulary aligns with typical development and how children use core and fringe vocabulary within their utterances.

Method:
Descriptive and inferential statistics were used to analyze 112 transcripts to describe how typically developing toddlers (aged 2.5 years) use core and fringe vocabulary within their utterances, in reference to a range of commonly used core vocabulary lists.

Results:
Results indicated that the proportion of the toddlers' utterances that consisted of only core, only fringe, or core + fringe vocabulary varied dramatically depending on the size of the core vocabulary list used, with smaller core lists yielding few “core-only” utterances. Furthermore, utterances containing both core and fringe vocabulary were both grammatically and semantically superior to utterances containing only core or only fringe vocabulary, as evidenced by measures such as mean length of utterance and total number of words.

Conclusion:
Thus, relying on word frequency counts is an insufficient basis for selecting vocabulary for aided preliterate communicators.
Ein frischer Wind
Authors: Hohmann Mima , von Bremen Dörte , Walkenhorst Michael 
Published: March 2024

Liebe Leserin, lieber Lesernun halten Sie sie also in Händen, die erste ZGTM-Ausgabe des neuen
Herausgeber*innenteams. Wir sind sehr froh, dass dies der Fall ist, denn im März
2023 stand es haarscharf auf der Kippe, ob es die ZGTM in dieser Form weiterhin
geben würde. Mit deutlicher Mehrheit sprach sich die Mitgliederversammlung der
Gesellschaft für Ganzheitliche Tiermedizin (GGTM) aber für den Erhalt der ZGTM aus.
Danach folgte eine kurze Phase des luftleeren Raumes, als nichts geklärt und
entschieden war, bis schließlich im Sommer bei der Klausurtagung des erweiterten
Vorstands spontan eine kreative Diskussion die entscheidende Wendung brachte und wir
drei wie die Jungfrau zum Kinde kamen. Dem Entschluss folgte direkt ein sprudelnder
Quell an Themenvorschlägen für Inhalte, Rubriken, Autoren und ehe wir uns versahen,
stand ein komplettes Zeitungsgerüst für die vier Ausgaben 2024.
Seltene Nervenkompressionssyndrome
Authors: Carolus Anne , Uerschels Anne-Kathrin 
Published: March 2024

Zusammenfassung
Seltene
Kompressionssyndrome
Angesichts ihrer langen Verläufe, den komplexen
Topographien zwischen Muskeln, unter Bändern und Muskelfaszienkanten sowie dem
Verlauf nahe knöcherner Strukturen sind periphere Nerven prädisponiert für
lokale Kompressionen. Daraus resultieren viele Engpasssyndrome – für fast jeden
Nerv ist ein solches beschrieben. Der Artikel soll eine systematische Übersicht
über Symptome, Diagnostik und Therapie geben, wobei er sich auf die weniger
bekannten Syndrome konzentriert.Zu den seltenen Kompressionssyndromen im
Bereich des Schultergürtels gehören das Suprascapularis-Syndrom, das
Kompressionssyndrom des N. axillaris im spatium quadrilaterale und die
Kompression des N. thoracicus longus. Im Unterarm sind das M. pronator-teres-
und N. interosseus-anterior-Syndrom als seltenere Kompressionssyndrome des N.
medianus beschrieben. Am Unterarmverlauf des N. radialis kann das
Supinatorlogensyndrom auftreten. Das Loge de Guyon-Syndrom liefert das
ulnarseitige Pendant zum weitaus bekannteren Karpaltunnelsyndrom der Hand. Bei
der Cheralgia paraesthetica handelt es sich um eine Einengung des sensiblen N.
radialis-Astes zum Daumenrücken.
An der unteren Extremität können sämtliche
Nerven der Leisten- und Oberschenkelregion eingeengt werden, die Passage zwischen
den Blättern der schrägen Bauchmuskulatur bzw. unter dem Leistenband ist hierfür
prädisponierend. Die Meralgia paraesthetica mit einer Affektion des N. cutaneus
femoris lateralis ist hier das bekannteste Syndrom. Nahezu nur iatrogen treten
Engpässe des N. femoralis oder N. obturatorius auf. Bei lateralen Schmerzen in der
distalen Oberschenkel-/Knieregion vor allem nach orthopädischen Eingriffen am
Kniegelenk sollte an eine Kompression oder Läsion des intrapatellaren N.
Saphenus-Astes gedacht werden. Das Piriformislücken-Syndrom beschreibt eine
wahrscheinlich muskuläre Einengung des N. ischiadicus und gilt als
unterdiagnostiziert. Im Unterschenkel- und Fußbereich existieren mehrere
Kompressionssyndrome des N. peronaeus und des N. tibialis, darunter die
Nervenkompression am Fibulaköpfchen, das vordere und hintere Tarsaltunnelsyndrom und
die Morton-Metatarsalgie.
Dynamic Level of Fibronectin in Calcium Hydroxide and Mineral Trioxide Aggregate Used as Pulp-Capping Materials
Authors: Trilaksana Aries Chandra , Dwiandhany Wahyuni Suci , Nagaret Fuista Rica 
Published: March 2024

Abstract
Objectives The aim of this study was to evaluate the dynamics of fibronectin levels in teeth treated with pulp capping using calcium hydroxide (Ca(OH)2) and mineral trioxide aggregate (MTA).
Materials and Methods Test mice were divided into two treatment groups for pulp capping, with group 1 receiving Ca(OH)2 and group 2 receiving MTA. The maxillary first molars of each group's six rats were pulp capped. After pulp capping, blood samples were collected at 1 hour, 24 hours, and 48 hours. A subsequent analysis of the ELISA—enzyme-linked immunosorbent assay—data was performed on additional samples. Hasanuddin University's Faculty of Medicine's Research Ethics Committee allowed the use of experimental animals.
Statistical analysis The data normality test uses the Kolmogorov-Smirnov test (sample > 50) or the Shapiro-Wilk test (sample 50) to identify the analytical application of the distribution of the standard data. Wilk test outcomes had a value of p > 0.05; for both the fibronectin and Shapiro leptin levels, the data are considered to be normally distributed.
Results Following the application of Ca(OH)2 and MTA to the treated tooth pulp capping, changes in the levels of leptin and fibronectin were observed after 1 hour, 24 hours, and 48 hours. These changes generally tended to decrease leptin levels and increase fibronectin levels.
Conclusion As a pulp-capping material, the results showed that MTA materials have higher levels of dynamics of fibronectin than Ca(OH)2. This indicates MTA is a better material for pulp-capping treatment.
Structures and bonding characteristics of KCl(H2O)n clusters with n = 1–10 based on density functional theory
Authors: Shi Ying , Li Mengxu , Jia Nan , Shi Ruili , Su Yan 
Published: March 2024

Aqueous inorganic salt solutions play a prominent role in both physiological and chemical experiments, and significant attention has been directed toward understanding the mechanisms underlying salt dissolution. In our effort to elucidate the hydration process of potassium chloride, we employed a comprehensive genetic algorithm to explore the structures of KCl(H2O)n (n = 1–10). A series of stable structures were identified by high-level ab initio optimization and single-point energy calculations with a zero-point energy correction. An analysis of the probability distribution of KCl(H2O)1–10 revealed that clusters with high probability at low temperatures exhibit reduced probabilities at higher temperatures, while others become more prevalent. When n = 1–9, the contact ion pair configurations or partially dissociated structures dominate in the system, and the probability distribution plot shows that the proportion of the solvent-separated ion pair (SSIP) structures of KCl(H2O)n is very small, while the SSIP configuration in KCl(H2O)10 becomes a stable structure with increasing temperature. The results from natural bond orbital analysis reveal a stronger interaction between chloride ions and water molecules. These findings provide valuable insights for a more comprehensive understanding of the intricacies of potassium chloride dissolution in water.
An inverse problem for a transmission wave equation with a flat interface in
Rn
Authors: Mercado-Saucedo Alberto 
Published: March 2024

Abstract
In this paper we study a wave equation with discontinuous principal coefficient within a bounded domain of arbitrary dimension. It is obtained the stability of the inverse problem of recovering a space-dependent coefficient by observing a trace of the corresponding solution on part of the boundary. We provide a precise estimate of the minimum required time, as a function of the velocity change and domain size. The main tools are new global Carleman estimates for the transmission system with a particular weight function adapted to the interface geometry, which allows to obtain an optimal estimate of the minimum time.
Bandgap engineering of spinel-structured oxide semiconductor alloys
Authors: Ota Yuichi , Kaneko Kentaro , Onuma Takeyoshi , Fujita Shizuo 
Published: March 2024

Abstract
We investigated bandgap engineering of spinel-structured MgB
2O4 (B = Al, Ga, In) alloys. The trend of bandgap change was tunable from approximated 7.8–3.6 eV by substituting group III cation atoms in MgB
2O4. To evaluate the doping possibility, we have calculated the natural band alignment and doping pinning energy of the normal and inverse spinel structures of MgB
2O4 alloys. The calculated doping pinning energies show that spinel-structured MgB
2O4 alloys can potentially control the electron concentration, but hole doping is difficult. Our computational results are expected to provide new insights into the doping control of ultra-wide bandgap semiconductors.
Non-thermal plasma for decontamination of bacteria trapped in particulate matter filters: plasma source characteristics and antibacterial potential
Authors: Helmke Andreas , Curril Ingrid , Mrotzek Julia , Schulz Jannik , Viöl Wolfgang 
Published: March 2024

Abstract
The aims of this study encompass the characterization of process parameters and the antimicrobial potential during operation of a novel non-thermal plasma (NTP) source in a duct system containing a particulate matter (PM) filter thus mimicking the interior of an air purifier. Simulating conditions of a long-term operation scenario, in which bacterial aerosols in indoor environments accumulate on PM filters, the filter surfaces were artificially inoculated with Escherichia coli (E. coli) and exposed to an air stream enriched with reactive species. Electrical power consumption, key plasma parameters, volume flow and air flow velocity, reactive gas species concentrations as well as inactivation rates of E. coli were assessed. The NTP operated at a gas temperature close to ambient air temperature and featured a mean electron energy of 9.4 eV and an electron density of 1∙1019 m−3. Ozone was found to be the dominating reactive gas species with concentrations of approx. 10 ppm in close vicinity to the PM filters. An inactivation rate of 99.96 % could be observed after exposure of the PM filters to the gas stream for 15 min. This inactivation efficiency appears very competitive in combating realistic bacterial aerosol concentrations in indoor environments.
Linewidth characterization of a self-traceable grating by SEM
Authors: Guo P , Miao H , Mao S F , Zou Y B , Deng X , Cheng X B , Ding Z J 
Published: March 2024

Abstract
To achieve high-precision nanometrology, a self-traceable grating reference material has been reported and prepared using atom lithography and soft x-ray interference techniques (Liu et al 2021 Nanotechnology
32 175 301). In this work, we employ a Monte Carlo simulation method to investigate the scanning electron microscopy (SEM) image contrast and linewidth characterization of the grating linewidth. The 3D structure of mushroom-shaped grating lines made of multilayers (Pt, SiO2 and Si) is modeled according to transmission electron microscopy (TEM) images, enabling the SEM linescan profiles of secondary electron signals to be obtained for different values of structural linewidth parameters from Monte Carlo simulations. Using the principle of the model-based library method, a model database of Monte Carlo-simulated SEM linescan profiles is thus constructed by varying the incident electron beam conditions and the grating linewidths; then, the grating linewidth is successfully characterized using experimental SEM images. The comparison with the TEM measurement reveals that the measurement accuracy is verified to within 0.3% for the linewidth of ∼25 nm.
Instability of multi-mode systems with quadratic Hamiltonians
Authors: Leu Xuanloc , Thi Nguyen Xuan-Hoai , Lee Jinhyoung 
Published: March 2024

Abstract
We present a novel geometric approach for determining the unique structure of a Hamiltonian and establishing an instability criterion for quantum quadratic systems. Our geometric criterion provides insights into the underlying geometric perspective of instability: A quantum quadratic system is dynamically unstable if and only if its Hamiltonian is non-elliptic (i.e., hyperbolic or lineal). By applying our geometric method, we analyze the stability of two-mode and three-mode optomechanical systems. Remarkably, our approach demonstrates that these systems can be stabilized over a wider range of system parameters compared to the conventional rotating wave approximation (RWA) assumption. Furthermore, we reveal that the systems transit their phases from stable to unstable, when the system parameters cross specific critical boundaries. The results imply the presence of multistability in the optomechanical systems.
Non-Kramers doublet ground state in a quaternary cubic compound PrRu2In2Zn18 investigated by ultrasonic measurements
Authors: Zhang 张 Hua-Yuan 化远 , Wakiya Kazuhei , Nakamura Mitsuteru , Yoshizawa Masahito , Nakanish Yoshiki 
Published: March 2024

Abstract
We performed ultrasonic measurements on a quaternary cubic compound PrRu2In2Zn18 to explore the ground state properties derived from non-Kramers Γ3 doublet of Pr3+. PrRu2In2Zn18 is a quaternary derivative of the ternary compound PrRu2Zn20 that exhibits a structural phase transition at T
S = 138 K. In PrRu2In2Zn18, the Zn atoms at the 16c site in PrRu2Zn20 are selectively replaced by In atoms. A monotonic increase was observed in the temperature dependence of elastic constants C
L = (C
11 + 2C
12 + 4C
44)/3 and C
T = (C
11–C
12 + C
44)/3 in the temperature range around T
S to which an elastic softening was observed in (C
11 – C
12)/2 for PrRu2Zn20. The disappearance of the softening indicates that the structural transition in PrRu2Zn20 is suppressed by the substitution of Zn ions by In ones with a larger ionic radius. Alternatively, the C
T of PrRu2In2Zn18 exhibits a precursor Curie-type elastic softening toward low temperatures being responsible for the non-Kramers Γ3 ground state. We discuss the ground state and the evolution of the elastic properties of the different single-crystal samples of PrRu2In2Zn18 grown under different conditions.
A fully spiking coupled model of a deep neural network and a recurrent attractor explains dynamics of decision making in an object recognition task
Authors: Sadeghnejad Naser , Ezoji Mehdi , Ebrahimpour Reza , Qodosi Mohamad , Zabbah Sajjad 
Published: March 2024

Abstract

Objective. Object recognition and making a choice regarding the recognized object is pivotal for most animals. This process in the brain contains information representation and decision making steps which both take different amount of times for different objects. While dynamics of object recognition and decision making are usually ignored in object recognition models, here we proposed a fully spiking hierarchical model, explaining the process of object recognition from information representation to making decision. Approach. Coupling a deep neural network and a recurrent attractor based decision making model beside using spike time dependent plasticity learning rules in several convolutional and pooling layers, we proposed a model which can resemble brain behaviors during an object recognition task. We also measured human choices and reaction times in a psychophysical object recognition task and used it as a reference to evaluate the model. Main results. The proposed model explains not only the probability of making a correct decision but also the time that it takes to make a decision. Importantly, neural firing rates in both feature representation and decision making levels mimic the observed patterns in animal studies (number of spikes (p-value < 10−173) and the time of the peak response (p-value < 10−31) are significantly modulated with the strength of the stimulus). Moreover, the speed-accuracy trade-off as a well-known characteristic of decision making process in the brain is also observed in the model (changing the decision bound significantly affect the reaction time (p-value < 10−59) and accuracy (p-value < 10−165)). Significance. We proposed a fully spiking deep neural network which can explain dynamics of making decision about an object in both neural and behavioral level. Results showed that there is a strong and significant correlation (r = 0.57) between the reaction time of the model and of human participants in the psychophysical object recognition task.