bluuebunny/crossref_metadata_2025_split huggingface dataset:
Participação da comunidade no SUS: o desafio da inserção das propostas de uma conferência estadual no plano de saúde correspondente
Authors: Nascimento de Farias Roberto , Aurélio Marques Renan , Finkelsztejn Rodrigo , Brandt Gualdi Carolina 
Published: April 2024

A incorporação das demandas de conferências de saúde em seus respectivos planos tem se mostrado um desafio para a efetiva participação da comunidade no planejamento do Sistema Único de Saúde. Assim, este estudo teve por objetivo analisar tal processo de formulação de política pública a partir de uma abordagem qualitativa com base documental, em nível estadual. Para fins comparativos, as propostas do Relatório Consolidado da 8ª Conferência Estadual de Saúde do Rio Grande do Sul e as metas do Plano Estadual de Saúde correspondente foram sistematizadas em seis macrocategorias, subdivididas em 20 categorias operacionais, de acordo com políticas, ações e serviços de saúde, verificando-se em que medida as demandas das propostas foram contempladas pelas metas do PES. Constatou-se que somente 20% das propostas foram inseridas no Plano correspondente. Inúmeros fatores podem contribuir para esse distanciamento entre os documentos analisados, tais como o elevado número de propostas, expressivo percentual de propostas intersetoriais, questões de redação, entre outros. Além disso, sugere-se que uma etapa intermediária, entre a conferência e o Plano, poderia representar uma oportunidade de melhoria para o processamento técnico das propostas, a fim de torná-las exequíveis e passíveis de incorporação.

Palavras-chave: Participação Social; Planejamento Governamental; Planejamento em Saúde; Participação da Comunidade; Controle Social; Conferências de Saúde.
QUANDO ESTAMOS DE FATO FORMADOS? SOCIALIZAÇÃO DA LINGUAGEM, AS INQUIETAÇÕES DO PROFESSOR E O ENSINO DE LINGUA INGLESA
Authors: Sanches Gabriel Jean 
Published: April 2024

RESUMO: Este trabalho apresenta reflexões sobre a formação docente a partir de um projeto de extensão e o modo como as experiências nestes espaços contribuem para a aquisição e performance da linguagem. Os participantes do estudo são licenciandos/as do curso de Letras e suas reflexões que giram em torno de como agir e pensar sobre/a sala de aula, assim como os materiais, a partir do projeto desenvolvido juntamente com professores da Educação Básica do estado do Paraná. Os dados foram analisados a partir da socialização da linguagem, conforme propõem Baquedano-Lopez (2002), Occhs e Schiffellin (2000) e também apoiado na perspectiva de uma Linguística Aplicada indisciplinar conforme defende Moita Lopes (2000) e o pensamento de fronteira presente em estudos da Antropologia, assim como da Linguística Aplicada Crítica sobre decolonialidade (MIGNOLO, 2012). Os conceitos foram adotados para pensar em nossas práticas e o modo como articulamos nossos dizeres em contextos de formação por entender que essa é uma temática bastante importante a ser explorada.
Palavras-chave: Formação docente; Socialização da linguagem; extensão;
LITERATURA ENTRANHADA DE MULHERES NEGRAS (DES)ENRAIZADAS
Authors: Fernandez Raffaella  Andrea 
Published: April 2024

Resumo: Esse texto pensa o encontro literário entre Françoise Ega (1920 - 1976) e Carolina Maria de Jesus (1914/1919/1921-1977). Ambas escritoras negras que encontraram na literatura um espaço para imaginar, curar, transmutar e tecer percursos possíveis em seus processos diaspóricos. Seja a martinicana Ega escrevendo em Marseille, seja a minera Carolina situada em São Paulo, em seus respectivos espaços distantes de onde viveram até a adolescência, formularam e nutriram seus textos-raízes não apenas como um retorno às suas origens, mas também como fomento e recomposição de novos enraizamentos. Ega, expande e entranha suas palavras-linhas até o Brasil reconhecendo em Carolina um espelho de onde brota memórias em suas missivas, jamais lidas pela autora brasileira, mas, no entanto, encontrou na atual recepção a constatação de que persistem as “misérias dos pobres do mundo inteiro (que) se parecem como irmãs”.
Palavras-chave: Carolina Maria de Jesus; Françoise Ega; Literatura negra; diáspora; missiva;
Eficacia del trabajo con familias en duelo complicado por COVID-19 en el primer nivel
Authors: Medina-Hernández Thalía Selene , Garrido-Pérez Silvia María Guadalupe , Sánchez Rodríguez Rosa Maria , Castillo-Orueta María Luisa , Avalos-García María Isabel 
Published: April 2024

Objetivo Determinar la eficacia del trabajo con familias en fase de duelo complicado por COVID-19, para restablecer la homeostasis y dinámica familiar.
Material y Métodos Estudio con enfoque mixto, bajo un diseño cuasi experimental. Se desarrolló en tres etapas: diagnóstica, intervención y evaluación. En la primera se encuestaron 99 personas que perdieron a un familiar durante la pandemia con el test Inventario de duelo complicado (IDC) y el FF.SIL para estudiar la funcionalidad familiar. Se realizó intervención a cinco familias con duelo complicado y disfunción familiar, mediante trece sesiones presenciales y el empleo de técnicas de terapia narrativa y Gestalt, con la finalidad de recuperar la homeostasis familiar. Para evaluar el efecto de la intervención se aplicó un pos-test, así como los comentarios de las familias. Se realizó prueba t de Student para la diferencia pre y pos-test.
Resultados Se encontraron familias con duelo complicado y disfunción familiar en el 25.3%. En el pretest-postest del FF-SIL, la prueba T de Student observó diferencia de medias de Ⱦ=8.571, desviación estándar de s±7.387, intervalo de confianza de IC95% Li: 4.306; Ls: 12.837 y valor de t= 4.341, gl=13 y valor de p=0.0001, estadísticamente significativo.
Conclusión Con la intervención se logró restablecer la homeostasis, dinámica y salud familiar.

Palabras clave: Efecto; COVID-19; Duelo; Dinámica Familiar; Homeostasis.
A Study on the Establishment of a Faculty of Chinese Proficient Teachers and the Development Model of Chinese Expert Thai Teachers at the Primary and Secondary level in Thailand
Authors: Kaewbut Pichai 
Published: April 2024

The development of Chinese teachers in Thailand has been going on for a long time. At the present time, Thai Chinese teachers are the important resource persons on driving Chinese language teaching in Thailand. The study of the establishment of a panel of Chinese language proficient teachers and the development model of Chinese language proficient teachers in the primary and secondary level in Thailand is one of the important education issues at present. The objective of this research is to study the establishment of a panel of teachers who are experts in Chinese language and the development model of Chinese language proficient teachers in the primary and secondary schools in Thailand. The data was collected from 21 training sessions from Thai Chinese teachers nationwide. Altogether 1,400 teachers participated in the training during 2020-2022. The research methods include literature analysis, observation, and focus group interview. The results of the study showed that: 1) A panel of teachers who specialize in Chinese at various levels should be established concretely. 2) The development model of Chinese proficient teachers should be categorized in development, and 3) To promote and develop in order to increase the number of expert Chinese teachers.
Research on the Influence of Sand-Mud Interlayer Properties on the Expansion of SAGD Steam Chamber
Authors: An Guoqiang , Sun Hai , Ye Xiangdong , Li Aifen , Guo Wanjiang , Fu Shuaishi , Liu Shiqi , Zhu Yongchun , Hu Zhuocheng 
Published: April 2024

Summary
Thermal recovery techniques serve as the primary approach for developing heavy oil due to its high viscosity and poor flowability. In this study, we established a high-temperature and high-pressure 3D physical experimental and numerical model based on the unique reservoir characteristics of the sand-mud interlayer in the Long Lake oil sands of Canada, using similarity criteria. Physical and numerical experiments employing steam-assisted gravity drainage (SAGD) were conducted to investigate the impact of sand-mud interlayer properties on the expansion limit of steam chambers during SAGD development. The results indicate that the expansion mode and limit of the steam chamber play a decisive role in heavy oil mobilization. Notably, heat loss during steam chamber expansion and the flow resistance caused by the interlayer are critical factors influencing the SAGD process. The presence of the interlayer extends the mobilization range in the lower portion of the reservoir, but it also limits the upward expansion of the steam chamber, resulting in a reduced mobilization range above the interlayer. Moreover, the steam chamber above the interlayer exhibits a distinct expansion pattern, featuring concave sides and a convex middle, resembling a “positive triangle.” Furthermore, the properties of the sand-mud interlayer and production parameters significantly affect the expansion limit of the steam chamber. Permeability and position exert a substantial impact on recovery, whereas thickness has a minor influence. Specifically, at an injection rate of 20 mL·min–1, steam quality of approximately 0.7, and a production/injection ratio of approximately 1.0, the steam chamber can successfully penetrate interlayers with a thickness of either 3.5 m and a permeability of 100×10−3 μm2 or 4.5 m and a permeability of 200×10−3 μm2.
Plane straight elements with semi-rigid connections: formulation from an energetic approach
Authors: Sousa Rafael , Pitaluga F.H. , Cheung Andrés 
Published: April 2024

Abstract

This work presents the analytical development of the stiffness matrix of a plane straight element with semi-rigid connections and its support reactions for three loading cases from the application of the Principle of Virtual Work. Semi-rigid connections are represented by translational and rotational linear elastic springs at both ends of the element, giving it six degrees of freedom. One example shows the application of this formulation using the Classical Displacement Method and the results are also obtained numerically via the Finite Element Method.
Statistical analysis plan for the TRANSLATE (TRANSrectal biopsy versus Local Anaesthetic Transperineal biopsy Evaluation of potentially clinically significant prostate cancer) multicentre randomised controlled trial
Authors: Marian Ioana R , Ooms Alexander , Holmes Jane , Parkes Matthew J , Lamb Alastair D , Bryant Richard J 
Published: April 2024

Abstract

Background
The TRANSLATE (TRANSrectal biopsy versus Local Anaesthetic Transperineal biopsy Evaluation) trial assesses the clinical and cost effectiveness of two biopsy procedures in terms of detection of clinically significant Prostate Cancer (PCa). This article describes the statistical analysis plan (SAP) for the TRANSLATE randomised controlled trial (RCT).
Methods/design:
TRANSLATE is a parallel, superiority, multicentre RCT. Biopsy-naïve men aged ≥ 18 years requiring a prostate biopsy for suspicion of possible PCa are randomised (computer-generated 1:1 allocation ratio) to one of two biopsy procedures: Transrectal (TRUS) or Local Anaesthetic Transperineal (LATP) biopsy. The primary outcome is the difference in detection rates of clinically significant PCa (defined as Gleason Grade Group ≥ 2, i.e. any Gleason pattern ≥ 4 disease) between the two biopsy procedures. Secondary outcome measures are ProBE questionnaire (Perception Part and General Symptoms) and International Index of Erectile Function (IIEF, Domain A) scores, International Prostate Symptom Score (IPSS) values, EQ-5D-5L scores, resource use, infection rates, complications, and serious adverse events. We describe in detail the sample size calculation, statistical models used for the analysis, handling of missing data, and planned sensitivity and subgroup analyses. This SAP was pre-specified, written and submitted without prior knowledge of the trial results.
Discussion
Publication of the TRANSLATE trial SAP aims to increase transparency of the data analysis and reduce the risk of outcome reporting bias. Any deviations from to the current SAP will be described and justified in the final study report and results publication.
Trial registration:
International Standard Randomised Controlled Trial Number ISRCTN98159689, registered on 28 January 2021 and registered on the ClinTrials.gov (NCT05179694) trials registry.
Funding/sponsor: National Institute of Health Research Health Technology Assessment Programme (Reference number NIHR131233).
The myelin water imaging transcriptome: myelin water fraction regionally varies with oligodendrocyte-specific gene expression
Authors: Lee Jaimie J. , Scheuren Paulina S. , Liu Hanwen , Laule Cornelia , Loucks Catrina M. , Kramer John L.K. 
Published: April 2024

Abstract

Identifying sensitive and specific measures that can quantify myelin are instrumental in characterizing microstructural changes in neurological conditions. Neuroimaging transcriptomics is emerging as a valuable technique in this regard, offering insights into the molecular basis of promising candidates for myelin quantification, such as myelin water fraction (MWF). We aimed to demonstrate the utility of neuroimaging transcriptomics by validating MWF as a myelin measure. Data from a normative MWF brain atlas, comprised of 50 healthy subjects (mean age = 25 years, range = 17–42 years) scanned at 3 Tesla was utilized. Magnetic resonance imaging data included myelin water imaging to extract MWF and T1 anatomical scans for image registration and segmentation. We investigated the inter-regional distributions of gene expression data from the Allen Human Brain Atlas in conjunction with inter-regional MWF distribution patterns. Pearson correlations were used to identify genes with expression profiles mirroring MWF. The Single Cell Type Atlas from the Human Protein Atlas was leveraged to classify genes into gene sets with high cell type specificity, and a control gene set with low cell type specificity. Then, we compared the Pearson correlation coefficients for each gene set to determine if cell type-specific gene expression signatures correlate with MWF. Pearson correlation coefficients between MWF and gene expression for oligodendrocytes and adipocytes were significantly higher than for the control gene set, whereas correlations between MWF and inhibitory/excitatory neurons were significantly lower. Our approach in integrating transcriptomics with neuroimaging measures supports an emerging technique for understanding and validating MRI-derived markers such as MWF.
Multivariate analysis of the effects of environmental factors on plant diversity and composition in the Afar Rangelands, Northeast Ethiopia
Authors: Gemeda Wakshum Shiferaw 
Published: April 2024

Abstract

The structure and biodiversity of natural vegetative communities are increasingly threatened by invasive species. Prosopis juliflora (Fabaceae) is a major invasive shrub in Africa, Australia, and North America. However, how its invasion is related to plant diversity and composition, and whether this varies with aspect, altitude, slope, and anthropogenic disturbances remains poorly understood. The aims of this study were to evaluate the relationships between P. juliflora invasion, floristic diversity and composition, and altitude, slope, aspect, and anthropogenic disturbance in the Afar region of Northeastern Ethiopia. The research examined two main hypotheses: (1) P. juliflora invasion was related to the diversity of native plant species; (2) native species diversity decreased with increasing aspect, altitude, slope, anthropogenic disturbances, and grazing. Sixty-four sample quadrats were placed in woodland vegetation using stratified random sampling. Quadrats measuring 1 m2, 100 m2, and 400 m2 were used to record the abundance and percent cover of herbs, seedlings and saplings, and trees, respectively. Physiographic variables and human activities were also recorded in the 400 m2 quadrats. Plant species diversity was unaffected by aspect, slope, grazing intensity, and disturbance (p > 0.05). However, plant diversity and composition were affected by altitude, P. juliflora invasion levels, and anthropogenic factors (p < 0.05). Three plant community types were identified using canonical correspondence analysis and P. juliflora had a negative relationship with native plant diversity in the third plant community type. Revisiting plots in the future will provide evidence to support lower plant diversity as a cause or effect of P. juliflora invasion.
An aid diagnostic platform to detect the transition of mild cognitive impairment (MCI) to Alzheimer's disease (AD) based on 48,116 AD and MCI patients
Authors: Song You-Qiang , LI JING , Li Siwen , Shea Yat-fung , Yue Ming , Zhu Pengfei , Zou Quan , Yuan Shuofeng , Chu Leung-Wing 
Published: April 2024

Abstract
Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disorder, necessitating early diagnosis and intervention. Mild cognitive impairment (MCI) often precedes AD, but not all cases progress to AD, emphasizing the need for predictive biomarkers. We analyzed routine blood test data from 43,981 AD patients and 4,537 MCI subjects in Hong Kong hospitals (2000-2019). Among 31 shared biomarkers, five blood biomarkers (Hemoglobin, Hematocrit, Red blood cell related to oxygen carrying capacity, Neutrophils, and White blood cell related to immunity) significantly differentiated MCI from AD. Subjects were divided into four groups (Female 65 ~ 74, Male 65 ~ 74, Female 75 ~ 89, Male 75 ~ 89) to minimize gender and age bias. Models utilizing the five biomarkers along with machine learning yielded the highest accuracy in the Female 65 ~ 74 group (AUC of 0.76 on an independent test set). The other three models were trained with other biomarkers besides these 5 to optimize predictions, capturing models with AUC close to 0.70. We then constructed a platform predicting the risk of MCI converting to AD (MAP, http://lab.malab.cn/~lijing/MAP.html) to help physicians and MCI subjects with early diagnosis and prevention of AD. In conclusion, this study demonstrates the potential for accurate prediction of MCI to AD conversion using routine blood test data and machine learning, offering an economical and practical approach for early AD screening in MCI individuals.
Predicting the Implications of Climatic Alterations on the Distribution of Endangered Species: A Case Study of Saxifragaceae on the Qinghai-Tibet Plateau
Authors: Sun Chenglin , Chen Wenpeng , Liu Yuping , Liu Tao , Su Xu , Zhou Yonghui , Wang Dong , Li Xiaoli , Ma Xiaoyan , Wei Chengrong , Wang Shengtao , Suonan Nima , Nizamani Mir Muhammad 
Published: April 2024

Abstract

Understanding the potential effects of climate change on species distribution is vital for the conservation of endangered taxa. The Saxifragaceae family, known to be susceptible to habitat disturbance, has a diverse distribution. While a significant portion is found on the Qinghai-Tibet Plateau (QTP), about half the species of Saxifraga are native to Europe, and other genera, such as Heuchera, have their centers of diversity in regions like North America and Japan. In this study, we employ the Maximum Entropy (MaxEnt) model in conjunction with Shared Socioeconomic Pathways (SSPs) to assess the potential influence of climate change on the distribution and richness of four endangered Saxifragaceae species (Saxifraga cernua L., Saxifraga tangutica Engl., Saxifraga przewalskii Engl. ex-Maxim., Saxifraga unguiculata Engl.) on the QTP, spanning time periods from the Last Glacial Maximum to 2080. Our results indicate that factors such as elevation, slope, mean annual temperature, isothermality, precipitation seasonality, and precipitation during the wettest quarter significantly affect species distribution patterns. Historical climate models demonstrate that approximately 30% of the QTP provided highly suitable habitat for Saxifragaceae species. Current projections suggest that this proportion has increased to over 30% and is anticipated to remain above 30% for the subsequent three-time intervals. Optimal habitats have been identified in southeastern QTP, western Sichuan, and northern Yunnan. The taxa are predicted to shift southward in response to future climate changes. Our findings underscore the importance of implementing conservation strategies that prioritize the establishment of protected areas in the southeastern QTP to safeguard these vulnerable Saxifragaceae species.
Single-cell and spatial transcriptomic analyses reveal the cellular origins and drivers of liver metastasis from pancreatic cancer
Authors: Cui Jing , Guo Yao , Chen Taoyu , Ling Yan , Liang Xueyi , Zhao Jingyuan , Xiong Jiongxin , Yin Tao , Ke Zunxiang , Peng Tao 
Published: April 2024

Abstract

Pancreatic cancer is a deadliest malignancy. The most common event of tumor progression in pancreatic cancer is liver metastasis, and current treatments have not produced the desired results. However, the cellular origins and drivers of liver metastasis have yet to be defined. In this study, we identified nine cell clusters in pancreatic cancer via analyzing single-cell transcriptomic profiles. Malignant epithelial cells in liver metastatic group might come from primary tumor subclones with 27 common gene copy number variation. Cell-cell communication demonstrated that malignant epithelial cells were specifically regulated by IL-1, Periostin, and IFN-II signaling pathways and fibroblasts regulated malignant epithelial cells through the Periostin pathway (POSTN-ITGAV/ITGB5). Moreover, we found that 34 differentially expressed genes were highly enriched in PI3K signaling pathway. Next, we constructed a LM index using these 34 genes, and found that pancreatic cancer patients with high-index exhibited a poor prognosis. The immuno-fluorescence staining assay showed that the spatial distance between POSTN and ITGAV was close, and ITGAV protein was expressed in tissue sections of pancreatic cancer patients. Finally, we found that ITGAV was upregulated in PANC-1 cells, and knockdown of ITGAV inhibited the invasion and migration of PANC-1 cells. This study clarified possible cellular origins and driv-ers of LM pancreatic cancer based on the single-cell and spatial transcriptomic profiles, and dis-covered that the ITGAV mRNA and protein were expressed in pancreatic cancer tissue and cells, and the knockdown of ITGAV inhibited the progression of pancreatic cancer.
A Bioinspired C–O/C–X σ-Bond Metathesis
Authors: Xie Youwei , Liu Hongmei , Zheng Yuzhu , Xian Ke-Lin , Hu Qi-Qi , Liao Rong-Zhen 
Published: April 2024

Abstract
Cross metathesis reactions of multiple bonds, such as alkenes and alkynes, have undoubtedly revolutionized various fields and become one of the most efficient strategies in organic synthesis. In contrast, metathesis reactions of more naturally abundant yet less reactive σ-bond bonds remain less developed, especially for polar C–X bonds, the existing activation modes are rather limited and reactions often occur between two C–X bonds of the same type. Here, inspired by the natural S-adenosylmethionine (SAM) cycle, we devise a σ-bond metathesis between the C–O bond of alcohols with various other different C–X bonds. This reaction is realized by using a delicate mixture of commonly used Lewis acids and allows fast access to various challenging thioethers or selenoethers from easily available ones by directly editing the C component of the C–X bond with easily available alcohols as the sources of the new C component. Like multiple bond metathesis, this method could also be rendered intramolecular to provide saturated heterocycles such as cyclic ethers, cyclic thioethers, as well as cyclic amines. Mechanistic experiments and DFT calculations were carried out to show a high level of resemblance to the natural SAM cycle. We anticipate this bioinspired design of C–O/ C–X metathesis will infuse the area of a σ-bond metathesis with more insights and provide opportunities for further advances in areas that have been facilitated by traditional C–X bond forming reactions.