bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progression‐free survival is a weakly predictive surrogate end‐point for overall survival in follicular lymphoma: A systematic review and meta‐analysis
Authors: Milrod Charles J. , Kim Kang Woo , Raker Christina , Ollila Thomas A. , Olszewski Adam J. , Pelcovits Ari 
Published: April 2024

SummaryAlthough progression‐free survival (PFS) is a commonly used surrogate end‐point for clinical trials of follicular lymphoma (FL), no analyses have evaluated the strength of surrogacy for PFS with overall survival (OS). A systematic review was performed and 20 studies (total participants, 10 724) met final inclusion criteria. PFS was weakly associated with OS (correlation coefficient; 0.383, p < 0.001). The coefficient of determination was 0.15 (95% CI: 0.002–0.35) suggesting 15% of OS variance could be explained by changes in PFS. This challenges the role for PFS as a surrogate end‐point for clinical trials and drug approvals.
Downregulation of ABCC3 activates MAPK signaling through accumulation of deoxycholic acid in colorectal cancer cells
Authors: Sato Yukihiro , Kobayashi Minoru , Ohira Masahiro , Funayama Ryo , Maekawa Masamitsu , Karasawa Hideaki , Kashiwagi Ryosuke , Aoyama Yayoi , Mano Nariyasu , Ohnuma Shinobu , Unno Michiaki , Nakayama Keiko 
Published: April 2024

AbstractABCC3 (also known as MRP3) is an ATP binding cassette transporter for bile acids, whose expression is downregulated in colorectal cancer through the Wnt/β‐catenin signaling pathway. However, it remained unclear how downregulation of ABCC3 expression contributes to colorectal carcinogenesis. We explored the role of ABCC3 in the progression of colorectal cancer—in particular, focusing on the regulation of bile acid export. Gene expression analysis of colorectal adenoma isolated from familial adenomatous polyposis patients revealed that genes related to bile acid secretion including ABCC3 were downregulated as early as at the stage of adenoma formation. Knockdown or overexpression of ABCC3 increased or decreased intracellular concentration of deoxycholic acid, a secondary bile acid, respectively, in colorectal cancer cells. Forced expression of ABCC3 suppressed deoxycholic acid‐induced activation of MAPK signaling. Finally, we found that nonsteroidal anti‐inflammatory drugs increased ABCC3 expression in colorectal cancer cells, suggesting that ABCC3 could be one of the targets for therapeutic intervention of familial adenomatous polyposis. Our data thus suggest that downregulation of ABCC3 expression contributes to colorectal carcinogenesis through the regulation of intracellular accumulation of bile acids and activity of MAPK signaling.
Rev1 overexpression accelerates N‐methyl‐N‐nitrosourea (MNU)‐induced thymic lymphoma by increasing mutagenesis
Authors: Sasatani Megumi , Xi Yang , Daino Kazuhiro , Ishikawa Atsuko , Masuda Yuji , Kajimura Junko , Piao Jinlian , Zaharieva Elena Karamfilova , Honda Hiroaki , Zhou Guanyu , Hamasaki Kanya , Kusunoki Yoichiro , Shimura Tsutomu , Kakinuma Shizuko , Shimada Yoshiya , Doi Kazutaka , Ishikawa‐Fujiwara Tomoko , Sotomaru Yusuke , Kamiya Kenji 
Published: April 2024

AbstractRev1 has two important functions in the translesion synthesis pathway, including dCMP transferase activity, and acts as a scaffolding protein for other polymerases involved in translesion synthesis. However, the role of Rev1 in mutagenesis and tumorigenesis in vivo remains unclear. We previously generated Rev1‐overexpressing (Rev1‐Tg) mice and reported that they exhibited a significantly increased incidence of intestinal adenoma and thymic lymphoma (TL) after N‐methyl‐N‐nitrosourea (MNU) treatment. In this study, we investigated mutagenesis of MNU‐induced TL tumorigenesis in wild‐type (WT) and Rev1‐Tg mice using diverse approaches, including whole‐exome sequencing (WES). In Rev1‐Tg TLs, the mutation frequency was higher than that in WT TL in most cases. However, no difference in the number of nonsynonymous mutations in the Catalogue of Somatic Mutations in Cancer (COSMIC) genes was observed, and mutations involved in Notch1 and MAPK signaling were similarly detected in both TLs. Mutational signature analysis of WT and Rev1‐Tg TLs revealed cosine similarity with COSMIC mutational SBS5 (aging‐related) and SBS11 (alkylation‐related). Interestingly, the total number of mutations, but not the genotypes of WT and Rev1‐Tg, was positively correlated with the relative contribution of SBS5 in individual TLs, suggesting that genetic instability could be accelerated in Rev1‐Tg TLs. Finally, we demonstrated that preleukemic cells could be detected earlier in Rev1‐Tg mice than in WT mice, following MNU treatment. In conclusion, Rev1 overexpression accelerates mutagenesis and increases the incidence of MNU‐induced TL by shortening the latency period, which may be associated with more frequent DNA damage‐induced genetic instability.
Colonial trauma: Terrains of disappearance, traumatic reflexivity, and historicizing countertransference
Authors: Khan Nichola 
Published: April 2024

AbstractThis article analyzes trauma as an interplay of mass violence connecting imperial occupation in British Hong Kong, and an Anglo‐Chinese family in England. It takes Devereux's concept of countertransference to interrogate how killings in the author's family reverberate as traumatic transferences in fieldwork engaging the transgenerational violence of Partition in postcolonial Pakistan. Routing through transferences, it advances a comparative analysis of colonial trauma; moving from the individual to universal through layerings of traumatic silence, existential struggles, and the unconscious. It asks: what kinds of reflexivity are entailed by the double‐nature of the traumatized subject writing about trauma? Can colonial trauma retain specificity, while speaking to the discordant temporal settlement and relational formation of broader interconnected histories, geographical partitions, and generational loss? Psychological anthropology offers a mode for filling in blanks; privileging the subjectivity of inheritors of colonial trauma for ethnographic theorizations into ways anthropologists might reckon with the psychic violence of colonial pasts.
Dental management of people with complex or rare inherited bleeding disorders
Authors: Nanayakkara Lochana , Yahaya Norjehan , Parreira Miryam , Bajkin Branislav 
Published: April 2024

AbstractAdvances in haematological therapies for people with complex or rare inherited bleeding disorders (IBD) have resulted in them living longer, retaining their natural teeth with greater expectations of function and aesthetics. Dental management strategies need to evolve to meet these challenges. Utilising low level laser diode therapy to reduce pre‐operative inflammation to reduce the intraoperative and postoperative burden on haemostasis is described in a case series of 12 patients. For these individuals who previously required further medical management to support haemostasis or experienced such prolonged haemorrhage sufficient to warrant hospital admission, haemostasis was achieved in the dental surgery such that they were able to return home with no further medical intervention or overnight stays. Global inequities in accessing novel treatments for complex or rare IBD necessitates a comprehensive understanding of the local haemostatic agents available to dentists and the most commonly used agents and techniques are described including the use of single tooth anaesthesia (STA). STA is a computerised delivery mechanism that allows routine dental procedures that would previously have required block injections needing factor replacement therapy to be undertaken safely and effectively with no additional haemostatic intervention. The challenges of inhibitors in oral surgery are explained and discussed although more research and evidence is required to establish new treatment protocols. The importance of establishing good dental health in the quality of life of people with complex or rare IBD is highlighted with respect to the dental specific impact that more novel therapies may have on people with IBD.
Interesting UV and visible photodetection properties of GZO‐based device
Authors: Rejeb Mabrouka , Souissi Riadh , Alaya Chaouki Ben , Abderrabba Manef , Bouguila Noureddine , Bouaicha Mongi 
Published: April 2024

AbstractThe aim of this study is to investigate the performance of chemically deposited Ga doped ZnO (GZO) thin film for enhanced UV and visible light detection. Transparent thin film was grown on glass substrates by a spray pyrolysis technique. The Ga doping concentration was maintained at 1 at.% in the solution. The influence of gallium concentration in zinc oxide (ZnO) films on structural, morphological, electrical, and optical properties was studied.Measurements of the photoconductivity were performed by DC electrical tool under visible and UV illuminations. Obtained results reported in this study on the performances of the fabricated GZO based device reveal that the photoresponse, rapidity, photosensivity, responsivity, detectivity, and reproducibility of the device are very interesting in photodetection, especially in UV wavelength domain. We notice that the device has a good responsivity as compared to detectors fabricated using other techniques, with a rather good repeatability. Furthermore, the electronic conductivity mechanism is modeled as an ohmic one.
Multiple aspects of tree beta diversity in coastal ecosystems in Brazil
Authors: da Silva Oliveira Eduardo Vinícius , Landim Myrna Friederichs , Gouveia Sidney F. 
Published: April 2024

AbstractAimPatterns of beta diversity reflect the formation dynamics of ecological communities. Here, we integrated geographic, phylogenetic, and phenotypic information of coastal woody vegetation to investigate (1) whether the observed dissimilarity between assemblages differs from that expected by chance, examining the roles of spatial and deterministic processes; (2) the relative contribution of beta‐diversity components (turnover and nestedness) for taxonomic, phylogenetic, and functional beta diversity; and (3) what environmental factors drive the differences in composition between assemblages for all these dimensions.LocationBrazil.TaxonAngiosperm trees.MethodsWe built dissimilarity matrices and partitioned the taxonomic, phylogenetic, and functional beta diversity from an incidence matrix, a phylogeny including the region's plants, and a matrix expressing functional distances. Using linear regressions, we tested the effects of different environmental predictors representative of the effects of water availability, thermal energy, habitat heterogeneity, edaphic constraints, climatic stability, and human influence on beta‐diversity patterns.ResultsTaxonomic, phylogenetic, and functional dissimilarities exhibited a typical pattern of greater dissimilarity with distance (i.e., as expected by chance). However, these patterns showed different contributions of beta‐diversity components, predominating turnover in taxonomic and phylogenetic dissimilarity, and nestedness in functional dissimilarity. Water availability had a slight effect on patterns of taxonomic and phylogenetic dissimilarities.Main conclusionsThe Brazilian coastal woody vegetation appears to have emerged through a dynamic of colonisation of evolutionarily distinct but functionally similar lineages that originated from adjacent phytogeographic domains, proportional to their diversity. This is consistent with a combination of both neutral and non‐neutral processes. Our findings underscore the complementary roles of different dimensions of beta diversity in explaining the dynamics of these vegetation communities.
Trust Matters in the Single Market, but How? Analysing Trust Amongst European Financial Supervisors
Authors: Versluis Esther , Michel Niklas , Spendzharova Aneta 
Published: April 2024

AbstractEuropean regulatory co‐operation has become essential for the smooth operation of the single market, and this in turn requires trust. In the case of the European Union (EU) ‘Undertakings for Collective Investment in Transferable Securities’ (UCITS) Directive, for example, the member states' financial supervisory authorities rely on each other to provide a harmonised regime for the sale of investment funds across the EU. Funds authorised in one member state can be sold freely in another member state without further authorisation. The national authorities need to trust each other to ensure a consistent application of EU law. Yet we know very little about how trust matters from the perspective of member state regulators. In this article, we provide a better understanding of the relevant components of trust in the single market in financial services through an in‐depth case study of an EU network of national financial market supervisory authorities.
Maddison‐style estimates of the evolution of the world economy: A new 2023 update
Authors: Bolt Jutta , van Zanden Jan Luiten 
Published: April 2024

AbstractThis paper surveys the literature on historical national accounting, discusses the importance of relative income benchmarks for, in particular, historical income estimates, and presents an update of long run global economic development with a new version of the Maddison Project Database (MPD). As benchmarks are central to methodologies for global income comparisons over time, and therefore vital to MPD, we analyze the consequences and biases of three benchmarks, the 1990 benchmark, the 2011 benchmark and the multiple benchmark method following the recent Penn World Tables (PWT) methodology, for pre‐1940 income estimates. We develop a methodology to determine which benchmark in combination with time series produces the best anchor for the historical income estimates in the MPD. We conclude that the best way forward for the Maddison Project is to stick to the original 1990 benchmark, yet with two important changes. First, we integrate the 2011 benchmark for the post‐1990 period, and second, we fine tune the dataset for the pre‐1940 period by integrating a new historical benchmark for the US/UK comparison in 1909. By integrating more benchmarks, the MPD moves closer to a multiple benchmark approach as developed by the PWT.
Maxillary interim obturator prosthesis fabrication for a patient with limited mouth opening with a digital approach: A clinical report
Authors: Shahid Omar , Alhayek Abdulhadi , Ahmed Zain Uddin , Aslam Nomara , Aldawood Tuqa , Morgano Steven M. , DiFazio Joseph 
Published: April 2024

AbstractSquamous cell carcinoma is a common malignant condition affecting the oral cavity and may involve the surrounding maxillofacial regions. Treatment commonly involves resection of the tumor, followed by prosthetic rehabilitation of the resection defect. This clinical report presents a 62‐year‐old Asian male patient who had previously undergone surgical resection, resulting in a post‐surgical Aramany Class II maxillary defect. The patient's medical history included severe trismus, characterized by restricted mouth opening, as well as a diagnosis of maxillary sinus verrucous squamous cell carcinoma. This report provides a comprehensive account of the rapid fabrication of an interim obturator using digitally assisted dentistry techniques.
Current status of interspecies somatic cell nuclear transfer and meta‐analysis of the effects of phylogenetic distance on embryonic and fetal development
Authors: Adams Laura , Liu Ying , Polejaeva Irina A. 
Published: April 2024

Abstract

Interspecies somatic cell nuclear transfer (iSCNT) has the capacity to rescue endangered species, ethically produce human embryonic stem cells, and allow for more specific analysis of pre‐implantation embryos. However, several obstacles negatively affect iSCNT efficiency.

Over 100 iSCNT studies have been published between 1999 and the spring of 2023. This review details the possible benefits of iSCNT, describes the hypothesized issues that prevented the development of some embryos and/or live offspring from developing; and analyzes the cleavage, blastocyst, pregnancy, live birth, and iSCNT efficiency rates based on published data.

Embryos produced by iSCNT may help with the rescue of endangered species and the production of human embryonic stem cells with the use of oocytes from domestic species, as well as in‐depth analyses of embryonic genome activation (EGA) and mRNA transcripts. But the combination of the cells of two species in a single embryo presents several challenges: lack of EGA synchronisation, presence of mitochondrial DNA (mtDNA) from both species in the embryo, requirement of cell and embryo culture optimization for each species combination, lack of embryo transfer data, and an extremely low overall efficiency in terms of producing live offspring. Additional research on the aforementioned topics is warranted to increase iSCNT efficiency.
Intrapuparial development of Sarcophaga (Liopygia) ruficornis (Diptera: Sarcophagidae), a species of medical‐veterinary and forensic importance, under laboratory conditions
Authors: Duarte Marina Lopes , Nascimento Tatiane Aparecida , de Queiroz Margareth Maria Carvalho 
Published: April 2024

AbstractSarcophaga (=Parasarcophaga) (Liopygia) ruficornis (Fabricius, 1794) is a species of medical–veterinary and forensic importance, as its immatures cause myiasis in humans and animals and colonize carcasses and cadavers. Therefore, investigations into the biology and morphology of this species, with a particular focus on pupae that constitute ≥50% of the developmental period for the immatures, are pertinent. Although there are biological and morphological studies of pupae, the intrapuparial development at different temperatures has not yet been analysed. Therefore, the present study aimed to describe how temperature (22, 27 and 32 ± 1°C) affects the development and morphology of S. (L.) ruficornis pupae at 60 ± 10% relative humidity and a 12‐h photoperiod. Ten pupae were collected, euthanized and fixed every 4 h from pupariation until 24 h and every 8 h until the emergence of the first adult. Emergence occurred at 440, 272 and 232 h at 22, 27 and 32°C, with 590, 380 and 330 pupae, respectively. The highest mortality occurred at 32°C. Eight periods were defined, and sex was determined in pharate adult stage; in addition, 40 key morphological characteristics to estimate pupal age were presented. These findings can serve as a basis for studies on the biology and morphology of the pupa of S. (L.) ruficornis, particularly in bionomics, control and forensics, helping researchers and experts.
Topological insight of immune‐vascular distribution in peri‐implantitis lesions
Authors: Villalobos Veronica , Silva Ian , Morales Diego , Canelo Javiera , Garrido Mauricio , Carreño Leandro J. , Cavalla Franco , Dutzan Nicolas , Caceres Monica 
Published: April 2024

AbstractObjectiveTo characterize the distribution of macrophages, neutrophils, NK cells, and blood vessels in peri‐implantitis compared to healthy aged gingiva samples.Materials and MethodsThis observational study included eight gingival samples from peri‐implantitis and eight from periodontally healthy individuals. By immunofluorescence were identified neutrophils, NK cells, macrophages, and their pro‐inflammatory or pro‐healing phenotypes, and blood vessels. Two ROIs were designated as zone 1, connective tissue closest to the epithelium and zone 2, connective tissue over 200 microns from the rete ridges. Immune cells and vascular structures were quantified and characterized according to their distribution in both zones.ResultsTwo peri‐implantitis zones were characterized by unique macrophage phenotypes and blood vessel architecture. Blood vessels were larger in zone 2 in peri‐implantitis. A greater number of NK cells and macrophages were found in peri‐implantitis compared to healthy aged samples. A higher presence of pro‐inflammatory macrophages was found in zone 1 compared to zone 2. A similar proportion of pro‐inflammatory and pro‐healing macrophages were found in zone 2.ConclusionA specific distribution for pro‐inflammatory macrophages and vascular architecture is observed in peri‐implantitis. TNF‐α colocalizes with macrophages in the connective tissue near rete ridges. NK cells are more abundant in peri‐implantitis than in healthy samples.
Areca nut and oral cancer
Authors: Singh Arjun Gurmeet , Chaturvedi Pankaj 
Published: April 2024

AbstractIntroductionThe association between areca nut consumption and oral cancer has been a subject of increasing concern in global public health.Global perspectiveAreca nut, often chewed in various forms such as betel quid, is deeply rooted in cultural practices across Asia and other parts of the world. Epidemiological studies consistently reveal a significant correlation between areca nut use and the incidence of oral cancer, emphasizing the need for targeted preventive measures. The complex interplay of areca nut's bioactive compounds, particularly arecoline, with cellular processes, contributes to the initiation and progression of oral carcinogenesis. Mechanistic insights into the genotoxic and cytotoxic effects of its components underscore the urgency for comprehensive public health interventions.Public healthEfforts to address this public health challenge involve multidisciplinary approaches, encompassing education, policy implementation, and behavioral interventions. Understanding the socio‐cultural factors influencing areca nut consumption is pivotal for designing effective awareness campaigns and cessation programs.ConclusionAs oral cancer remains a significant global health burden, unraveling the nuanced relationship between areca nut and its role in oral carcinogenesis is crucial for advancing preventive strategies and mitigating the impact of this modifiable risk factor.
Disentangling the separate and combined effects of privatization and cooperation on local government service delivery
Authors: Bel Germà , Elston Thomas 
Published: April 2024

AbstractInter‐municipal cooperation is often regarded as an alternative to privatizing local public services. But cooperation and privatization can also be combined into a dual reform package in which several municipalities jointly issue contracts relating to multiple jurisdictions. Evaluation of these mixed cooperation‐privatization reforms rests on disentangling the separate and combined effects of each strategy. This we undertake for the case of solid waste collection in Catalonia, using environmental protection as our focal performance standard. Drawing on two waves of data (for 2000 and 2019) for 186 municipalities that together use all four combinations of public, private, single and cooperative service delivery, we show that superior environmental performance was initially confined to conventional cooperations involving only public production. But latterly, any form of cooperation, using public or private production, resulted in significant gains. This reinforces the need for evaluators to isolate the “active ingredient” in composite reforms.