bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence, Predictors, and Prognosis of Serious Infections in Takayasu Arteritis: A Cohort Study
Authors: Misra Durga Prasanna , Rathore Upendra , Jagtap Swapnil , Mishra Prabhaker , Thakare Darpan R. , Singh Kritika , Qamar Tooba , Singh Deeksha , Dixit Juhi , Behera Manas Ranjan , Jain Neeraj , Ora Manish , Bhadauria Dharmendra Singh , Gambhir Sanjay , Agarwal Vikas , Kumar Sudeep 
Published: April 2024

ObjectiveTo describe the incidence, risk factors, and outcomes associated with serious infections in patients with Takayasu arteritis (TA).MethodsSerious infections, defined as infections resulting in hospitalization or death or unusual infections like tuberculosis, were identified from a cohort of patients with TA. Corticosteroid and disease-modifying antirheumatic drug (DMARD) use at the time of serious infection was noted. Demographic characteristics, clinical presentation, angiography, and disease activity at presentation, and the use of DMARDs during follow-up were compared between patients with TA with or without serious infections. Mortality in patients with TA who developed serious infections was compared to those who did not using hazard ratios (HR; with 95% CI).ResultsOf 238 patients with TA, 38 (16%) had developed serious infections (50 episodes, multiple episodes in 8; 3 episodes resulted in death). Among the 38 initial episodes, 11/38 occurred in those not on corticosteroids and 14/38 in those not on DMARDs. Pneumonia (n = 19) was the most common infection, followed by tuberculosis (n = 12). Patients with TA who developed serious infections vs those who did not had higher disease activity at presentation (active disease 97.4% vs 69.5%, mean Indian Takayasu Arteritis Activity Score 2010 12.7 (SD 7.3) vs 10.2 (SD 7.0), mean Disease Extent Index in Takayasu Arteritis 11.2 (SD 6.1) vs 8.8 (SD 6.1) and were more frequently initiated on corticosteroids or DMARDs. HRs calculated using exponential parametric regression survival-time model revealed increased mortality rate in patients with TA who developed serious infections (HR 5.52, 95% CI 1.75-17.39).ConclusionSerious infections, which occurred in the absence of immunosuppressive treatment in approximately one-fifth of patients with TA, were associated with increased mortality in patients with TA.
Patients With Psoriatic Arthritis–Related Enthesitis and Persistence on Tofacitinib Under Real-World Conditions
Authors: Braña Ignacio , Loredo Marta , Pardo Estefanía , Burger Stefanie , Fernández-Bretón Eva , Queiro Rubén 
Published: April 2024

ObjectiveInformation on the persistence of tofacitinib (TOF) in psoriatic arthritis (PsA) is scarce in real-world conditions. Our objective was to analyze the persistence and safety of TOF under these conditions.MethodsThis was a single-center retrospective longitudinal observational study of all patients with PsA who received at least 1 dose of TOF. The main focus was on adverse events (AEs) and drug survival. Drug survival was analyzed by Kaplan-Meier curves and persistence explanatory factors by multivariate Cox regression models. The hazard ratio (HR) was used to measure association.ResultsSeventy-two patients were included, 54 women and 18 men, mean age 51.9 (SD 11.1) years, mean disease duration of 10.4 (SD 6.99) years. TOF was ≥ third line of therapy in > 70% of cases. The median survival was 13.0 (IQR 5.3-29.0) months. One-year retention rate was 52.7% (95% CI 42.4-65.6). TOF survival was not influenced by sex, disease duration, comorbidities, or line of treatment. Younger patients (HR 0.96,P= 0.01) and those with enthesitis (HR 0.37,P= 0.03) showed lower odds of drug discontinuation. The overall rate of AEs was 52.9 (95% CI 38.5-70.6)/100 person-years. Most AEs occurred during the first 6 months of exposure.ConclusionIn this real-world study, TOF showed a reasonably good retention rate in a PsA population that was mostly refractory to biologic and oral targeted synthetic disease-modifying antirheumatic drugs. There were no new causes for concern regarding safety. Patients with refractory PsA and enthesitis might be a specific target population for this drug.
Synergistic antibacterial effects of Trachyspermum ammi L. essential oil and sodium nitrite in combination on artificially inoculated food models
Authors: Malik T. , Sarkar O. , Pant S. 
Published: April 2024

The addition of carminative essential oils could be an approach for food preservation and would minimize or substitute chemical preservatives. In the present study, essential oils (n=11) namely, Anethum sowa, Cinnamomum zeylanicum, Citrus bergamia, Cymbopogon flexuosus, Cymbopogon martini, Cymbopogon winterianus, Elettaria cardamomum, Mentha arvensis, Ocimum basilicum, Salvia sclarea and Trachyspermum ammi, were screened against Aeromonas hydrophila and Listeria monocytogenes. The largest diameters of zone of inhibition, 19.9 ± 0.33 mm and 21.7 ± 0.58 mm, were exhibited by T. ammi essential oil against Aeromonas hydrophila and Listeria monocytogenes, respectively. Growth inhibition studies for T. ammi essential oil, sodium nitrite and their combinations were also carried out on cucumber, apple, gram flour soup and mutton broth models. The combination of T. ammi essential oil and sodium nitrite depicted synergism and was also effective in reducing the bacterial counts in artificially inoculated food systems.
Promotion of an Antitumor Immune Program by a Tumor-specific, Complement-activating Antibody
Authors: Saxena Ruchi , Bushey Ryan T , Campa Michael J , Gottlin Elizabeth B , Guo Jian , Patz Edward F , He You-Wen 
Published: April 2024

Abstract
Tumor-targeting Abs can be used to initiate an antitumor immune program, which appears essential to achieve a long-term durable clinical response to cancer. We previously identified an anti–complement factor H (CFH) autoantibody associated with patients with early-stage non–small cell lung cancer. We cloned from their peripheral B cells an mAb, GT103, that specifically recognizes CFH on tumor cells. Although the underlying mechanisms are not well defined, GT103 targets a conformationally distinct CFH epitope that is created when CFH is associated with tumor cells, kills tumor cells in vitro, and has potent antitumor activity in vivo. In the effort to better understand how an Ab targeting a tumor epitope can promote an effective antitumor immune response, we used the syngeneic CMT167 lung tumor C57BL/6 mouse model, and we found that murinized GT103 (mGT103) activates complement and enhances antitumor immunity through multiple pathways. It creates a favorable tumor microenvironment by decreasing immunosuppressive regulatory T cells and myeloid-derived suppressor cells, enhances Ag-specific effector T cells, and has an additive antitumor effect with anti-PD-L1 mAb. Furthermore, the immune landscape of tumors from early-stage patients expressing the anti-CFH autoantibody is associated with an immunologically active tumor microenvironment. More broadly, our results using an mAb cloned from autoantibody-expressing B cells provides novel, to our knowledge, mechanistic insights into how a tumor-specific, complement-activating Ab can generate an immune program to kill tumor cells and inhibit tumor growth.
Comparison of scoring systems for predicting short- and long-term type 2 diabetes remission after bariatric surgery
Authors: Baldane Süleyman , Celik Murat , Korez Muslu Kazim , Yilmaz Huseyin , Abusoglu Sedat , Kebapcilar Levent , Alptekin Husnu 
Published: April 2024

Abstract

Introduction:
Our study aimed to compare the short- and particularly long-term type 2 diabetes mellitus (T2DM) remission prediction abilities of ABCD, individualised metabolic surgery (IMS), DiaRem2, Ad-DiaRem and DiaBetter scoring systems in Turkish adult type 2 diabetic morbidly obese patients who underwent bariatric surgery.

Patients and Methods:
Our study was planned as a retrospective cohort study. A total of 137 patients with T2DM, including 78 sleeve gastrectomy (SG) and 59 Roux-en-Y gastric bypass (RYGB) patients, were included in the 1st-year evaluation after bariatric surgery, and a total of 115 patients with T2DM, including 64 SG and 51 RYGB patients, were included in the evaluation at the end of the 5th year.

Results:
In the 1st year after bariatric surgery, area under the ROC curve (AUC) values for diabetes remission scores were 0.863 for Ad-DiaRem, 0.896 for DiaBetter, 0.840 for DiaRem2, 0.727 for ABCD and 0.836 for IMS. At 5 years after bariatric surgery, the AUC values for diabetes remission were 0.834 for Ad-DiaRem, 0.888 for DiaBetter, 0.794 for DiaRem2, 0.730 for ABCD and 0.878 for IMS.

Conclusions:
According to our study, the DiaBetter score provided a better AUC value than the other scores both in the short and long term but showed similar predictive performance to Ad-DiaRem in the short term and IMS in the long term. We believe that DiaBetter and Ad-DiaRem scores might be more appropriate for short-term assessment and DiaBetter and IMS scores for long-term remission assessment.
Uso das Informações do Orçamento de Desempenho em Municípios no Brasil
Authors: Azevedo Ricardo Rocha de , Pigatto José Alexandre Magrini 
Published: April 2024

A pesquisa investiga quais fatores explicam o uso da informação de desempenho contida no processo orçamentário de Prefeituras Municipais. A análise foi realizada por meio de uma regressão OLS estimada a partir de dados coletados a partir de uma survey eletrônica com Prefeituras Municipais. Foi verificado que a legitimidade percebida, a estrutura do município, a transparência, e a participação social foram significantes para o uso das informações de desempenho no processo orçamentário. Por sua vez, as resistências políticas e de servidores não afetaram a utilização desse tipo de informação. Duas são as contribuições principais da pesquisa. Primeiro, avança na literatura de orçamento por resultados, considerando-se a escassez de pesquisas em governos locais e que tragam a percepção dos responsáveis pelo processo orçamentário nessa temática. Segundo, contribui com a discussão do orçamento por desempenho no contexto nacional em contraposição a sua estagnação, que pode ser explicada inclusive, pela baixa utilização da sua informação. A pesquisa discute as implicações da estagnação do planejamento por resultados frente a sua institucionalização na da legislação orçamentária o que é apontado como consequência da baixa legitimidade desse tipo de informação em municípios brasileiros.
PENGARUH PERTIMBANGAN SUSTAINABLE PRACTICES TERHADAP INTENSI PEMILIHAN VENUE DI KALANGAN PROFESSIONAL CONFERENCE ORGANIZER DAN PROFESSIONAL EVENT ORGANIZER
Authors: Syafganti Imam , Setyawan Heri , Rajoendah M Iqbal Katik , Mubarak Fauzi 
Published: April 2024

As the Meeting, Incentive, Convention, and Exhibition (MICE) sector in Indonesia continues to expand, awareness of the importance of reducing negative environmental impacts has emerged among various stakeholder groups. Choosing a venue that has incorporated sustainable practices is a crucial step in implementing MICE with environmental considerations. The purpose of this study is to ascertain the attitudes of MICE industry decision-makers toward the issue of sustainable practices and to assess the impact of this on behavior intention when selecting venues for MICE activities. To accomplish this goal, this study conducted an online (supervised) survey of meeting planners on Professional Conference Organizers (PCO) and Professional Event Organizers (PEO) who are members of company associations operating in the MICE industry. According to the research findings, most meeting planners have a favorable opinion of sustainable practices. Furthermore, it was also discovered that the variable of sustainable practices had a significant impact on the intention to select a venue for conducting MICE events. Finally, this study suggests that the dissemination and acceptance of environmentally friendly MICE practices among industrial stakeholders should focus on the meeting planner group at the middle to upper managerial levels
PERAN PELATIHAN DAN DISIPLIN KERJA TERHADAP KINERJA ASN (APARATUL SIPIL NEGARA) DENGAN MOTIVASI SEBAGAI VARIABEL INTERVENING PADA DINAS PEMBERDAYAAN MASYARAKAT DAN DESA KABUPATEN SERANG
Authors: Saleh Muhammad , Fauji Ade , Oktaviani Ummi Lathifah 
Published: April 2024

This research was conducted because there were problems related to human resources. The problems in question are Training, Work Discipline, Performance and Motivation as intervening variables.
The purpose of this was to determine the effect of training on employee performance, work discipline on employee performance, and motivation on employee performance.
This research uses a quantitative methods with a analysis tools in the form of parametric statistics. The population in this study was 33 with a sample size of 33 assisted by SmartPLS.
The results of that training has no effect on employee performance, work discipline has a positive and significant effect on employee performance, motivation has no effect on performance, training has a positive and significant effect on motivation, work discipline has a positive and significant effect on motivation, training through motivation as an intervening variable has no effect on performance, discipline through motivation as an intervening variable has no effect on performance.
This study concludes that the theories used and previous research can still be used at DinasPemberdayaan Masyarakat dan DesaKabupatenSerang
ANALISIS MANAJEMEN WAKTU KONSTRUKSI PEMBANGUNAN GEDUNG KLINIK UNIBA DENGAN MENGGUNAKAN METODE CPM DAN APLIKASI QM FOR WINDOWS V5
Authors: Laksa Suminar Putri Dwi , Setiawati Dwi Novi , Suzanti Wiwien 
Published: April 2024

Factors that influence the delay in the construction of the UNIBA clinic building is a lack of communication between labor and supervisor, delay shiping material, quality of job control, the intensity of rainfall. This research is to determine the analysis of the management planning of the construction. To find out the urgency of the use of barchart in the process of managing the construction of the UNIBA clinic building. Conclution in this problem the author uses the CPM method, barchart. In this CPM analysis there are several jobs that belong to the criticalpath, namely the critical path of the work of the UNIBA clinic building structure there are 10 jobs, namely preparatory work (A-7 days). Bored pilee (B-21 days) work. Pile cap (C-21 days). Floor plate work (H-14 days). Ladderwork (-3 days). Beam wor (N-21 days). Floor plate work (S-0-14 daays). Sanitair work (W-35). Ceiling work (S-42). Paint work (X-42). Conclution of the use of barchart in the process of managing the construction of th UNIBA clinic building timeliness, data objectivity, submitting information on time, to provide standards that can be used to measure or compare progress with status, to identify and isolate the most important information
Pengaruh Beban Kerja dan Lingkungan Kerja Terhadap Kinerja Karyawan Melalui Stres Kerja Sebagai Variabel Media-si PT Setia Alam Sinergi
Authors: Siska Nurma Pradhita  , Suhana  
Published: April 2024

This research aims to analyze the influence of workload and work environment on employee performance through work stress as mediating variable at PT Setia Alam Sinergi Semarang. Population of the research are 107 employees. Census sampling technique is used in the research. For data analysis, outer model measurements were carried out. Inner model measurements and hypothesis testing by processing the data uses the Partial Least Square-Structural Equation Modeling (PLS-SEM) with SmartPLS 4.0 software. Research findings show that (1) work burden has a negative and significant effect on employee performance, (2) the work environment does not have significant effect on employee stress, (3) workload has a positive and significant effect on work stress, (4) the work environment has a negative and significant effect on work stress. (5) work stress has a negative and significant effect on employee performance, (6) work stress mediates the relationship between workload and employee performance, (7) work stress mediates the relationship between the working environment and employee performance.
desafios da aplicabilidade da Lei Maria da Penha
Authors: Santos Dannyelly Kammylly Tenorio Alves dos , Silva Emilly Victoria Lino , Celestino Maria Gabriela Gomes , Lima Maria Laura Nascimento de , Lima Paulo Ricardo Silva , Peixoto Ana Lydia Vasco de Albuquerque 
Published: April 2024

Devido a tensões entre os marcos legais indígenas e normativos brasileiros, a Lei Maria da Penha tem dificuldade de ser implementada nas comunidades indígenas do Brasil. Os requisitos da lei conflitam entre os costumes culturais indígenas e os procedimentos para solução das controvérsias, dificultando sua implementação. O objetivo da pesquisa é analisar as dificuldades encontradas para a implementação da lei Maria da Penha nas comunidades indígenas. Discussões sobre tensões normativas, estruturas institucionais inadequadas e a importância da formação dos profissionais que atuam nessas áreas são necessárias para superar esses desafios. O sucesso da lei depende do equilíbrio entre a proteção das mulheres indígenas e o respeito às suas identidades culturais. A herança histórica do Brasil Colônia, que desfavorece mulheres e indígenas, está no cerne do problema da violência de gênero nas comunidades indígenas. Este estudo explora os desafios da aplicação da Lei Maria da Penha nas comunidades indígenas brasileiras, com base em uma revisão sistemática da literatura disponível no Google Acadêmico e Scielo. Os autores BANIWA; CANCIANI; KAGAN; MIHOMEM; MONT'AVÃO e SEGATO contribuíram para esse estudo. É uma pesquisa qualitativa que se concentra em uma análise interpretativa e subjetiva dos dados coletados, em vez de uma análise quantitativa.
Funções executivas e atencionais no paciente com enxaqueca
Authors: Magierek Valeska , Carvalho Letícia Silva Gomes de , Assis Camila Gualberto Bernardes de , Jurno Mauro Eduardo 
Published: April 2024

RESUMO
Introdução: A migrânea é uma doença que afeta o desempenho global do paciente (sobretudo Funções Executivas e atencionais) com impacto direto na funcionalidade da pessoa, evidenciando a importância de estudos, a fim de minimizar seus danos. Objetivo: Este estudo objetivou relacionar as Funções Executivas e atencionais com a migrânea, através de testes neuropsicológicos. Metodologia: Estudo de corte transversal (44 sujeitos; 29 migranosos e 15 não-migranosos), sobre alterações atencionais e executivas na migrânea. Foram incluídos no estudo, independentemente do sexo, sujeitos acima de 18 anos, recrutados por conveniência no CAM FAME, FAME e Centro AMA, seguindo os critérios da Classificação Internacional da Cefaleia (ICHD-3). Os sujeitos foram submetidos a testes neuropsicológicos que estimaram o funcionamento executivo e atencional. Para a atenção foi utilizada a Bateria Psicológica de Avaliação da Atenção (BPA) e para as funções Executivas foi utilizado o Teste dos Cinco Dígitos (FDT). Foram utilizados Teste T de Student, ANOVA, Teste U de Mann-Whitney e/ou Kruskal-Wallis, cujas análises fixaram o erro do tipo I em 0,05. Resultados: Todos os subtestes da BPA apontaram redução do potencial atencional nos migranosos quando comparados ao grupo controle. O FDT mostrou rebaixamento no grupo de sujeitos com migrânea, quando comparado com o dos não migranosos (inibição = 0, 3092; flexibilidade = 0, 2323). A análise multivariada identificou relação entre FE, Atenção e migrânea (p<0.05). Conclusão: Indivíduos com migrânea apresentam rebaixamento nas FE e nas Habilidades Atencionais e aumento no tempo de execução quando comparados com indivíduos não migranosos.

Palavras-chaves: Cefaleia, Migrânea, Funções Executivas, Atenção.
PERENCANAAN MANAJEMEN PENDIDIKAN DALAM UPAYA PEMBENTUKAN KARAKTER PESERTA DIDIK
Authors: Laana Darwis Lodowich 
Published: April 2024

Manajemen yang baik sangat dibutuhkan bagi lembaga pendidikan, secara khusus bagi pembentukan Â karakter sebagai suatu pengembangan untuk membentuk nilai-nilai karakter, nilai akhlak, moral dan perilaku yang baik terhadap peserta didik. Penelitian ini bertujuan untuk meningkatkan peran manajemen pendidikan dalam membentuk karakter peserta didik di lembaga pendidikan. Metode kajian literatur digunakan dalam penelitian ini untuk mengidentifikasi inti dari peran manajemen dalam pembentukan karakter. Tujuan dari penelitian ini yaitu untuk mengetahui apa itu manajemen pendikanÂ dan bagaimana peran manajemen pendidikan bagi pembentukan karakter. Hasil penelitian menunjukan bahwa, merupakan serangkaian aktivitas perencanaan, pengorganisasian, pelaksanaan, dan pengawasan yang bertujuan untuk mencapai tujuan organisasi dengan memanfaatkan sumber daya manusia dan sumber daya lainnya; dan peran manajemen pendidikan manajemen pendidikan memiliki tugas-tugas khusus yang dapat dilakukan melalui empat strategi alternatif. Pertama, menyatukan konten pendidikan karakter ke dalam semua mata pelajaran; kedua, mengintegrasikan pendidikan karakter ke dalam aktivitas sehari-hari di sekolah; ketiga, mengintegrasikan pendidikan karakter ke dalam aktivitas yang diprogramkan atau direncanakan; keempat, membangun komunikasi dan kerjasama yang erat antara sekolah dan orang tua siswa
Pembuatan teh rajangan herba sirih cina (Peperomia pellucida L. Kunth.)
Authors: Putra Risa Kota 
Published: April 2024

Latar belakang : Indonesia termasuk satu dari 17 negara megadiversitas (keanekaragaman hayati) terkaya di dunia, khususnya untuk tumbuhan berkhasiat obat. Di lain sisi pasar Indonesia malah dibanjiri produk-produk obat tradisional impor, karena masyarakat kurang menyadari betapa kayanya negeri sendiri akan sumber daya obat tradisional. Hal itu terbukti, disekitar rumah penduduk dengan mudah dan banyak ditemukan tumbuh liar, yang salah satu tumbuhan Suruhan atau Sirih cina (Peperomia pellucida L. Kunth.) yang berkhasiat menurunkan kholeterol dan asam urat dalam darah. Upaya menjawab tantangan itu, perlu dilakukan langkah-langkah penyadaran dan pengenalan kembali kepada masyarakat, baik untuk sector flora maupun faunanya.
Metode : Pengabdian kepada Masyrakat (PkM) ini dilaksanakan dalam bentuk sosialisasi yang bersifat kualitatif dan pengenalan tumbuhan Suruhan yang berkhasiat obat dan cara pembuatan sediaannya secara sederhana sehingga mudah dilakukan oleh masyarakat. Subjek PkM ini adalah kader kesehatan dan masyarakat di Desa Gurudug Kecamatan Pondoksalam Kabupaten Purwakarta.
Hasil : Peserta sosialisasi ini yaitu ibu-ibu kader kesehatan dan masyarakat Desa Gurudug Kecamatan Pondoksalam Kabupaten Purwakarta, telah memberikan respon yang disampaikan melalui jawaban kuesioner dan pertanyaan langsung ke narasumber. Respon dari peserta sangat setuju terhadap materi sosialisasi sesuai dengan kebutuhn masyarakat (93%); penyampaian jelas dan menarik (80%); waktu penyampaian cukup memadai (80%); masyarakat dapat manfaat (85,7%); perlu dilakukan berkelanjutan (80%); dan puas terhadap kegiatan penyuluhan ini (80%)
Simpulan : Kegiatan pengabdian kepada masyarakat (PkM) dalam bentuk kegiatan sosialisasi berupa paparan materi: Pembuatan Teh Rajangan Suruhan Peperomia pellucida, L. Kunt.) untuk pemeliharan kesehatan dan pencegahan penyakit, diapresiasi dengan sangat baik oleh peserta dan berharap agar dilakukan secara terus-menerus.