bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autonomous data extraction from peer reviewed literature for training machine learning models of oxidation potentials
Authors: Lee Siwoo , Heinen Stefan , Khan Danish , Anatole von Lilienfeld O 
Published: March 2024

Abstract
We present an automated data-collection pipeline involving a convolutional neural network and a large language model to extract user-specified tabular data from peer-reviewed literature. The pipeline is applied to 74 reports published between 1957 and 2014 with experimentally-measured oxidation potentials for 592 organic molecules (−0.75 to 3.58 V). After data curation (solvents, reference electrodes, and missed data points), we trained multiple supervised machine learning (ML) models reaching prediction errors similar to experimental uncertainty (∼0.2 V). For experimental measurements of identical molecules reported in multiple studies, we identified the most likely value based on out-of-sample ML predictions. Using the trained ML models, we then estimated oxidation potentials of ∼132k small organic molecules from the QM9 (quantum mechanics data for organic molecules with up to 9 atoms not counting hydrogens) data set, with predicted values spanning 0.21–3.46 V. Analysis of the QM9 predictions in terms of plausible descriptor-property trends suggests that aliphaticity increases the oxidation potential of an organic molecule on average from ∼1.5 V to ∼2 V, while an increase in number of heavy atoms lowers it systematically. The pipeline introduced offers significant reductions in human labor otherwise required for conventional manual data collection of experimental results, and exemplifies how to accelerate scientific research through automation.
Determination of droplet size from wide-angle light scattering image data using convolutional neural networks
Authors: Kirstein Tom , Aßmann Simon , Furat Orkun , Will Stefan , Schmidt Volker 
Published: March 2024

Abstract
Wide-angle light scattering (WALS) offers the possibility of a highly temporally and spatially resolved measurement of droplets in spray-based methods for nanoparticle synthesis. The size of these droplets is a critical variable affecting the final properties of synthesized materials such as hetero-aggregates. However, conventional methods for determining droplet sizes from WALS image data are labor-intensive and may introduce biases, particularly when applied to complex systems like spray flame synthesis. To address these challenges, we introduce a fully automatic machine learning-based approach that employs convolutional neural networks (CNNs) in order to streamline the droplet sizing process. This CNN-based methodology offers further advantages: it requires few manual labels and can utilize transfer learning, making it a promising alternative to conventional methods, specifically with respect to efficiency. To evaluate the performance of our machine learning models, we consider WALS data from an ethanol spray flame process at various heights above burner surface, where the models are trained and cross-validated on a large dataset comprising nearly 35000 WALS images.
WaveFormer: transformer-based denoising method for gravitational-wave data
Authors: Wang He , Zhou Yue , Cao Zhoujian , Guo Zongkuan , Ren Zhixiang 
Published: March 2024

Abstract
With the advent of gravitational-wave astronomy and the discovery of more compact binary coalescences, data quality improvement techniques are desired to handle the complex and overwhelming noise in gravitational wave (GW) observational data. Though recent machine learning-based studies have shown promising results for data denoising, they are unable to precisely recover both the GW signal amplitude and phase. To address such an issue, we develop a deep neural network centered workflow, WaveFormer, for significant noise suppression and signal recovery on observational data from the Laser Interferometer Gravitational-Wave Observatory (LIGO). The WaveFormer has a science-driven architecture design with hierarchical feature extraction across a broad frequency spectrum. As a result, the overall noise and glitch are decreased by more than one order of magnitude and the signal recovery error is roughly 1% and 7% for the phase and amplitude, respectively. Moreover, on 75 reported binary black hole events of LIGO we obtain a significant improvement of inverse false alarm rate. Our work highlights the potential of large neural networks in GW data analysis and, while primarily demonstrated on LIGO data, its adaptable design indicates promise for broader application within the International Gravitational-Wave Observatories Network in future observational runs.
The Perils of Gender Self-Determination: Global Shifts in Sex Reclassification Law and Policy
Authors: Katri Ido 
Published: March 2024

Abstract
The Article maps the global rise of the emerging gold standard for recognition and protection of trans populations: laws and policies allowing for self-identification of gender identity, commonly referred to as “gender self-determination.” The Article suggests that, while gender self-determination allows for greater access to resources and opportunities for transgender people because it removes grave breach to bodily autonomy, it also formulates “gender identity” as a private entity of the self, separated from publicly assigned sex. Thus, gender self-determination inevitably redraws the public–private divide along the contours of the transgender body, suggesting a need to examine the apparatus of assigning sex at birth and its pivotal role in both the systemic exclusions of trans people and gender inequality more broadly. To make this case, the Article provides a comparative review and analysis of laws and policies allowing for sex reclassification on identity documents from over a hundred jurisdictions worldwide, from a complete ban on classification, through medical and corroborations requirements, to gender self-identification. The Article demonstrates a shift within sex reclassification policies from the body to the self, from external to internal truth, revealing a growing emphasis on the separation of gender identity from sex in legal analysis, pointing to its possible detrimental effects on questions of sex-based equality. To secure the autonomy of the trans legal subject, self-determination laws and policies formulate gender identity as an inherent and internal feature of the self. Yet, the sovereignty of a right to gender identity is circumscribed by the system of sex classification and its individuating logics, in which one must be stamped with a sex classification to be an autonomous legal subject. Finally, the Article argues that addressing the distribution of life prospects along gender lines requires going back to the category of sex and critically rethinking its fundamental differentiating structures.
Implementation of endometrial cancer molecular subtyping into a hybrid community-academic practice
Authors: Ferreira Elizabeth O , Schefter Alexandra M , Brustad Abby , Klein Molly E , Khalifa Mahmoud A , Winterhoff Boris , Nelson Andrew C 
Published: March 2024

Abstract

Objectives
We sought to confirm utility of our institution’s modified Proactive Molecular Risk Classifier for Endometrial Cancer protocol in our daily practice, which includes mismatch repair (MMR), p53, and L1 cell adhesion molecule (L1CAM) immunohistochemistry with in-house next-generation sequencing for POLE, TP53, and CTNNB1.

Methods
We conducted a retrospective review of all patients in our institution who underwent primary endometrial carcinoma resection from the year prior to protocol implementation (PRE; October 1, 2020, to September 30, 2021) through first year of implementation (POST; October 1, 2021, to September 30, 2022) to compare the distribution of molecular and traditional staging factors using GOG-249 criteria to assign clinical risk.

Results
In total, 136 of 260 PRE patients were classified as clinically low risk (LR), of whom 31 were MMR deficient. Of the 157 LR POST patients with endometrioid-type carcinoma, 45 were MMR deficient, 5 were POLE mutant, 5 were TP53 mutant, 56 were of no specific molecular profile (NSMP), and 46 did not receive full protocol testing. Of all 79 POST NSMP endometrioid-type cases, 18 were CTNNB1 mutated and 8 showed L1CAM expression.

Conclusions
Our protocol identified 22 (14%) of 157 LR tumors that harbored incipient intermediate- to high-risk molecular aberrations in TP53, CTNNB1, or L1CAM. Moving forward, results of ongoing trials assessing adjuvant therapy decisions based on molecular classification are necessary to confirm protocol utility and identify appropriate modifications.
The Styles of Style
Authors: Roof Judith 
Published: March 2024

Abstract
This review considers two books—Benjamin Bateman’s Queer Disappearance in Modern and Contemporary Fiction and Taylor Black’s Style: A Queer Cosmology—that define and comment on queer male style in literature and culture. Each study defines style itself as a species of dynamic interrelationships among personal presentations, literary works, and cultural environments. Bateman’s book focuses on environmental issues in E. M. Forster’s Maurice, as well as on questions about the disappearances of birds. Sharing Bateman’s interest in birds, Black’s analysis demonstrates the ways the figure of the bird offers an apt analogy to queer male style.
Neonatal epidermolysis bullosa: a clinical practice guideline
Authors: Saad Rebecca , Duipmans José , Yerlett Natalie , Plevey Katie , McCuaig Catherine , Woolfe William , Steinau K , Phillips Jennifer , Azzopardi Nina , Thompson Kerry , Ferreira da Rocha Anna Carolina , Torres-Pradilla Maurico , Ott Hagen , Patton Declan , Moore Zena , Murphy Paul , Mayre-Chilton Kattya 
Published: March 2024

Abstract
DEBRA International is undertaking a long-term initiative to develop clinical practice guidelines (CPGs) for epidermolysis bullosa (EB), to ­improve the clinical care of people living with EB. Current neonatal care is based on evidence, clinical expertise and trial and error, with collaboration between the EB specialist team, parent or carer and patient, and is dependent on the neonate’s individual presentation and type of EB.
Early intervention based on research and clinical practice is needed to establish a foundation of knowledge to guide international practitioners to create and improve standards of care and to be able to work effectively with those newly diagnosed with EB. This CPG was created by an international panel with expertise working with persons with EB. The CPG focuses on neonatal care using a systematic review methodology covering four key areas: (i) diagnosis and parental psychosocial support; (ii) hospital management: medical monitoring, wound care and pain; (iii) feeding and nutrition; and (iv) discharge planning and EB education.
These four areas highlight the importance of a multidisciplinary team approach, to provide a patient-specific holistic care model that incorporates the needs and wishes of the parents and carers. The Hospital Implementation Tool included promotes transfer of theory to clinical practice.
Sustainable pathways to ammonia: a comprehensive review of green production approaches
Authors: Ahmed Hafiz Sharjeel , Yahya Zaid , Ali khan Waqar , Faraz Ali 
Published: March 2024

Abstract
Ammonia production is vital in global industries but faces increasing environmental concerns, necessitating a shift towards sustainable methods. This review comprehensively explores diverse hydrogen production approaches and their potential impact on sustainable ammonia synthesis. The primary focus is investigating hydrogen production methods that enhance both efficiency and sustainability in ammonia synthesis, which is crucial for reducing its environmental footprint. Furthermore, the review highlights the pivotal role of catalysts in improving Faradaic efficiency in ammonia synthesis, emphasizing their significance in overall process efficiency. The study identifies innovative technologies that have the potential to revolutionize ammonia production while aligning with global sustainability goals. Through a thorough examination of hydrogen production methods and catalytic advances, this review provides valuable insight into greener and more efficient ammonia production practices. In conclusion, it emphasizes the importance of exploring hydrogen production methods and leveraging catalysts to improve ammonia production sustainability and efficiency. It addresses a critical research gap and paves the way for an environmentally responsible and globally aligned ammonia production industry.
Assessing the biennial conference on science and technology (BICOST IX) 2023 technical output on renewable energy, energy storage, and green hydrogen in line with UN SDG commitments
Authors: Silva S K B D , Piyumali K G D , Perera Rasitha Thilini Suranjana , Kaluarachchi K D K G , Munagamage Thilini , Ahammed R M R , Piyankarage C S P , Shahmy Seyed , Karunaratne Veranja 
Published: March 2024

Abstract
The development, production and utilization of renewable energy, energy storage and green hydrogen and the associated technologies in Sri Lanka have great potential to contribute to the United Nations’ Sustainable Development Goals (SDGs). The island aims to achieve 70% electricity generation from renewable energy sources by 2030 (within the target of 40% utilization of renewable energy sources for the entire energy generation of the country by 2030). The power sector has to invest US$11 billion from 2023 to 2030 to contribute to reaching this target. This commentary aims to provide a critical perspective on the recommendations of the report from the National Science and Technology Commission’s 9th biennial conference in 2023 on science and technology, the sub-thematic technical report on clean energy, energy storage and green hydrogen in line with the SDGs in the Sri Lankan context. The technical report provides insightful recommendations for Sri Lanka’s energy sector under three main sections: renewable energy, energy storage and green hydrogen. Also, it explores the potential of various renewable energy sources, energy storage systems and green hydrogen as sustainable solutions to address the country’s energy challenges while emphasizing the spillover effects of them, which could contribute to the enterprise’s job creation and uplift the economy.
Efficacy of omalizumab for the treatment of bullous pemphigoid: Spanish multicentre real-world experience
Authors: Aguado Vázquez Álvaro , Estébanez Corrales Andrea , Melgosa Ramos F Javier , Mascaró Galy José Manuel , Fulgencio-Barbarin Jon , Bosch Amate Xavier , Curto Barredo Laia , Blanes-Martínez Mar , Ruiz-Villaverde Ricardo , Ballester Martínez Asunción , Martín-Torregrosa Daniel , Castaño Fernández Juan Luis , Cabeza Martínez Rita , Pérez-Ferriols Amparo , Ramos Rodríguez Daniel , Boix Vilanova Julian , Melé-Ninot Gemma , Expósito Serrano Vicente , España Alonso Agustin , Mateu-Puchades Almudena 
Published: March 2024

Abstract

Background
Bullous pemphigoid (BP) is the most common autoimmune blistering disease. Most patients are older and have associated multiple comorbidities. Topical and systemic corticosteroids are considered the first-line treatment for BP, and immunosuppressants are used as steroid-sparing treatments. However, both have side-effects and contraindications, which are even more common in this older population. New treatments targeting interleukins and receptors related to BP pathogenesis have been proposed to decrease these side-effects while achieving equal or better effectiveness and response rates. Omalizumab is a monoclonal antibody that targets IgE and has been proposed for the treatment of BP due to the evidence that IgE autoantibodies play an essential role in BP pathogenesis.

Objectives
To assess the efficacy and safety of omalizumab for the treatment of BP.

Methods
We carried out a multicentre, retrospective, observational study including patients diagnosed with BP who received omalizumab for ≥ 3 months from 15 tertiary hospitals in Spain. IgE levels prior to treatment were measured, and we evaluated the possible correlation with clinical response. We excluded patients treated with omalizumab for &lt; 3 months, as we consider this duration to be insufficient for a comprehensive assessment of its efficacy. To evaluate the effectiveness of the treatment, we used the percentage of body surface area improvement.

Results
We included 36 patients. The vast majority had associated multiple comorbidities, and all patients had used other systemic therapies apart from corticosteroids before omalizumab. In total, 83% experienced some kind of treatment response and 42% of all patients treated achieved complete response. We did not find any correlation between higher IgE levels and a better response (P = 0.2). All patients tolerated omalizumab without reported side-effects.

Conclusions
Omalizumab is a good therapeutic alternative for BP as it provided clinical response in most patients, and nearly one-half of the cases achieved complete response. It showed no side-effects, which is crucial in older patients with BP.
The developmental trajectory of 1H-MRS brain metabolites from childhood to adulthood
Authors: Thomson Alice R , Hwa Hannah , Pasanta Duanghathai , Hopwood Benjamin , Powell Helen J , Lawrence Ross , Tabuenca Zeus G , Arichi Tomoki , Edden Richard A E , Chai Xiaoqian , Puts Nicolaas A 
Published: March 2024

Abstract
Human brain development is ongoing throughout childhood, with for example, myelination of nerve fibers and refinement of synaptic connections continuing until early adulthood. 1H-Magnetic Resonance Spectroscopy (1H-MRS) can be used to quantify the concentrations of endogenous metabolites (e.g. glutamate and γ -aminobutyric acid (GABA)) in the human brain in vivo and so can provide valuable, tractable insight into the biochemical processes that support postnatal neurodevelopment. This can feasibly provide new insight into and aid the management of neurodevelopmental disorders by providing chemical markers of atypical development. This study aims to characterize the normative developmental trajectory of various brain metabolites, as measured by 1H-MRS from a midline posterior parietal voxel. We find significant non-linear trajectories for GABA+ (GABA plus macromolecules), Glx (glutamate + glutamine), total choline (tCho) and total creatine (tCr) concentrations. Glx and GABA+ concentrations steeply decrease across childhood, with more stable trajectories across early adulthood. tCr and tCho concentrations increase from childhood to early adulthood. Total N-acetyl aspartate (tNAA) and Myo-Inositol (mI) concentrations are relatively stable across development. Trajectories likely reflect fundamental neurodevelopmental processes (including local circuit refinement) which occur from childhood to early adulthood and can be associated with cognitive development; we find GABA+ concentrations significantly positively correlate with recognition memory scores.
CSF Biomarkers in Longitudinal Alzheimer Disease Cohorts: Pre-Analytic Challenges
Authors: Jonaitis Erin M , Jeffers Beckie , VandenLangenberg Monica , Ma Yue , Van Hulle Carol , Langhough Rebecca , Du Lianlian , Chin Nathaniel A , Przybelski Robert J , Hogan Kirk J , Christian Bradley T , Betthauser Tobey J , Okonkwo Ozioma C , Bendlin Barbara B , Asthana Sanjay , Carlsson Cynthia M , Johnson Sterling C 
Published: March 2024

Abstract

Background
The sensitivity of amyloid to pre-analytic factors complicates cerebrospinal fluid (CSF) diagnostics for Alzheimer disease. We report reliability and validity evidence for automated immunoassays from frozen and fresh CSF samples in an ongoing, single-site research program.

Methods
CSF samples were obtained from 2 Wisconsin cohorts (1256 measurements; 727 participants). Levels of amyloid beta 1–42 (Aβ42), phosphorylated tau 181 (pTau181), and total tau (tTau) were obtained using an Elecsys cobas e 601 platform. Repeatability and fixed effects of storage tube type, extraction method, and freezing were assessed via mixed models. Concordance with amyloid positron emission tomography (PET) was investigated with 238 participants having a temporally proximal PET scan.

Results
Repeatability was high with intraclass correlation (ICC) ≥0.9, but tube type strongly affected measurements. Discriminative accuracy for PET amyloid positivity was strong across tube types (area under the curve [AUC]: Aβ42, 0.87; pTau181Aβ42 , 0.96), although optimal thresholds differed.

Conclusions
Under real-world conditions, the Elecsys platform had high repeatability. However, strong effects of pre-analytic factors suggest caution in drawing longitudinal inferences.
Biventricular interaction and aortic function in adult patients with repaired tetralogy of Fallot: a two-dimensional–three-dimensional speckle-tracking echocardiographic study
Authors: Vitarelli Antonio , Capotosto Lidia , Miraldi Fabio , Mukred Khaled , Francone Marco , Galea Nicola , Mangieri Enrico , Tanzilli Gaetano , Viceconte Nicola , Mancone Massimo , Nguyen Bich Lien , Smaldone Costantino , Al-Kindy Sulaiman 
Published: March 2024

Abstract

Aims
In patients late after correction of tetralogy of Fallot (TOF), the combined effects of pre-operative hypertrophy and hypoxia, ventricular interdependence, acquired post-operative lesions such as pulmonary or aortic regurgitation, and congenital vasculopathy may result in impaired right ventricular (RV) and left ventricular (LV) function. The aim of the present study was to investigate the interventricular interactions in repaired TOF (rTOF) and the impact of aortic function on biventricular performance using two-dimensional (2D-STE) and three-dimensional speckle-tracking echocardiography (3D-STE).

Methods and results
Twenty-five adult patients with rTOF and 25 age- and gender-matched healthy controls were studied. LV and RV volumes were determined by 3D-STE and cardiac magnetic resonance. LV and RV longitudinal strains (LVLS and RVLS) and LV and RV area strains (LVAS and RVAS) and LV twist/rotation were calculated by 3D-STE. Ascending aorta circumferential strain (AAo-CS) was obtained using 2D-STE. LV 3D-STE parameters were decreased in rTOF patients compared with controls even in patients with normal ejection fraction. AAo-CS was decreased (6.7 ± 1.9 vs. 10.1 ± 2.6, P = 0.003) in rTOF patients compared with controls even in the presence of normal aortic dimensions and correlated with AAo diameter (r = −0.69, P = 0.0001), LV twist (r = 0.54, P = 0.004), LVAS (r = −0.56, P = 0.003), and RVLS (r = −0.39, P = 0.036). LVAS and AAo-CS were associated with disease severity (peak oxygen consumption and arrhythmia occurrence). Significant improvement in global χ2 value was noted with RV 3D-STE parameters + LVAS + AAo-CS compared with RV dysfunction alone for detecting exercise capacity impairment (from 77.1 to 84.4 to 91.2, P = 0.003).

Conclusion
Speckle-tracking echocardiography revealed subtle LV and AAo dysfunction in adults with rTOF. A correlation was observed between LV and RV strain changes and between AAo strain impairment and LV/RV dysfunction. LV and AAo changes had an incremental value in evaluating disease severity.