bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomechanical analysis of the maxillary sinus floor membrane during internal sinus floor elevation with implants at different angles of the maxillary sinus angles
Authors: Deng Yinxin , Ma Ruihong , He Yilin , Yu Shujia , Cao Shiyu , Gao Kang , Dou Yiping , Ma Pan 
Published: March 2024

Abstract
Objective
This study analyzed and compared the biomechanical properties of maxillary sinus floor mucosa with implants at three different maxillary sinus angles during a modified internal sinus floor elevation procedure.

Methods
3D reconstruction of the implant, maxillary sinus bone, and membrane were performed. The maxillary sinus model was set at three different angles. Two internal maxillary sinus elevation models were established, and finite element analysis was used to simulate the modified maxillary sinus elevation process. The implant was elevated to 10 mm at three maxillary sinus angles when the maxillary sinus floor membrane was separated by 0 and 4 mm. The stress of the maxillary sinus floor membrane was analyzed and compared.

Results
When the maxillary sinus floor membrane was separated by 0 mm and elevated to 10 mm, the peak stress values of the implant on the maxillary sinus floor membrane at three different angles were as follows: maxillary sinus I: 5.14–78.32 MPa; maxillary sinus II: 2.81–73.89 MPa; and maxillary sinus III: 2.82–51.87 MPa. When the maxillary sinus floor membrane was separated by 4 mm and elevated to 10 mm, the corresponding values were as follows: maxillary sinus I: 0.50–7.25 MPa; maxillary sinus II: 0.81–16.55 MPa; and maxillary sinus III: 0.49–22.74 MPa.

Conclusion
The risk of sinus floor membrane rupture is greatly reduced after adequate dissection of the maxillary sinus floor membrane when performing modified internal sinus elevation in a narrow maxillary sinus. In a wide maxillary sinus, the risk of rupture or perforation of the wider maxillary sinus floor is reduced, regardless of whether traditional or modified internal sinus elevation is performed at the same height.
Sight threatening diabetic retinopathy in patients with macular telangiectasia type 2
Authors: Huemer Josef , Heeren Tjebo FC , Olvera-Barrios Abraham , Faes Livia , Casella Antonio M. B. , Hughes Edward , Tufail Adnan , Egan Catherine 
Published: March 2024

Abstract
Purpose
Although diabetes is highly prevalent in patients with macular telangiectasia type 2 (MacTel), progression to severe non-proliferative (NPDR) and proliferative diabetic retinopathy (PDR) is rarely reported. We report multimodal imaging features of sight-threatening diabetic retinopathy (STDR) in eyes with MacTel.

Methods
Retrospective case series of seven participants of the MacTel Study at the Moorfields Eye Hospital NHS Foundation Trust study site and one patient from the Institute of Retina and Vitreous of Londrina, Brazil. Sight threatening diabetic retinopathy was defined as severe NPDR, PDR or diabetic macular edema.

Results
We report imaging features of 16 eyes of eight patients (7/8, 87.5% female) with diagnoses of MacTel and type 2 diabetes mellitus with STDR. Mean (SD) age was 56 (8.3) years. Patients were followed-up for a mean time of 9.1 (4.7) years. A total of 10/16 (62.5%) eyes showed PDR and 2/16 (12.5%) eyes presented a macular epiretinal neovascularization.

Conclusions
People with diabetes mellitus and MacTel may not be protected from STDR as previously reported. Although the two diseases rarely co-exist, regular monitoring for diabetic retinopathy progression is recommended according to baseline retinopathy severity grades in line with established international guidelines. The presence of MacTel may not modify extended screening intervals, but there is no current evidence. The limited case series in the literature support treatment for complications and should follow the standard of care for either condition. Due to dual pathology, reactivation may be difficult to diagnose on standard imaging and multimodal imaging is recommended.
PRO-Angoff method for remote standard setting: establishing clinical thresholds for the upper digestive disease tool
Authors: Lee Minji K. , Abou Chaar Mohamad K , Blackmon Shanda H , Yost Kathleen J 
Published: March 2024

Abstract
Background
The Upper Digestive Disease (UDD) Tool™ is used to monitor symptom frequency, intensity, and interference across nine symptom domains and includes two Patient-Reported Outcome Measurement Information System (PROMIS) domains assessing physical and mental health. This study aimed to establish cut scores for updated symptom domains through standard setting exercises and evaluate the effectiveness and acceptability of virtual standard setting.

Methods
The extended Angoff method was employed to determine cut scores. Subject matter experts refined performance descriptions for symptom control categories and achieved consensus. Domains were categorized into good, moderate, and poor symptom control. Two cut scores were established, differentiating good vs. moderate and moderate vs. poor. Panelists estimated average scores for 100 borderline patients per item. Cut scores were computed based on the sum of the average ratings for individual questions, converted to 0-100 scale.

Results
Performance descriptions were refined. Panelists discussed that interpretation of the scores should take into account the timing of symptoms after surgery and patient populations, and the importance of items asking symptom frequency, severity, and interference with daily life. The good/moderate cut scores ranged from 21.3 to 35.0 (mean 28.6, SD 3.6) across domains, and moderate/poor ranged from 47.5 to 71.3 (mean 54.5, SD 7.0).

Conclusions
Panelists were confident in the virtual standard setting process, expecting valid cut scores. Future studies can further validate the cut scores using patient perspectives and collect patient and physician preferences for displaying contextual items on patient- and physician-facing dashboard.
Multi-b-value DWI to evaluate the synergistic antiproliferation and anti-heterogeneity effects of bufalin plus sorafenib in an orthotopic HCC model
Authors: Guo Ran , Lu Fang , Lin Jiang , Fu Caixia , Liu Mengxiao , Yang Shuohui 
Published: March 2024

Abstract
Background
Multi-b-value diffusion-weighted imaging (DWI) with different postprocessing models allows for evaluating hepatocellular carcinoma (HCC) proliferation, spatial heterogeneity, and feasibility of treatment strategies. We assessed synergistic effects of bufalin+sorafenib in orthotopic HCC-LM3 xenograft nude mice by using intravoxel incoherent motion (IVIM), diffusion kurtosis imaging (DKI), a stretched exponential model (SEM), and a fractional-order calculus (FROC) model.

Methods
Twenty-four orthotopic HCC-LM3 xenograft mice were divided into bufalin+sorafenib, bufalin, sorafenib treatment groups, and a control group. Multi-b-value DWI was performed using a 3-T scanner after 3 weeks’ treatment to obtain true diffusion coefficient Dt, pseudo-diffusion coefficient Dp, perfusion fraction f, mean diffusivity (MD), mean kurtosis (MK), distributed diffusion coefficient (DDC), heterogeneity index α, diffusion coefficient D, fractional order parameter β, and microstructural quantity μ. Necrotic fraction (NF), standard deviation (SD) of hematoxylin-eosin staining, and microvessel density (MVD) of anti-CD31 staining were evaluated. Correlations of DWI parameters with histopathological results were analyzed, and measurements were compared among four groups.

Results
In the final 22 mice, f positively correlated with MVD (r = 0.679, p = 0.001). Significantly good correlations of MK (r = 0.677), α (r = -0.696), and β (r= -0.639) with SD were observed (all p < 0.010). f, MK, MVD, and SD were much lower, while MD, α, β, and NF were higher in bufalin plus sorafenib group than control group (all p < 0.050).

Conclusion
Evaluated by IVIM, DKI, SEM, and FROC, bufalin+sorafenib was found to inhibit tumor proliferation and angiogenesis and reduce spatial heterogeneity in HCC-LM3 models.

Relevance statement
Multi-b-value DWI provides potential metrics for evaluating the efficacy of treatment in HCC.

Key points
• Bufalin plus sorafenib combination may increase the effectiveness of HCC therapy.
• Multi-b-value DWI depicted HCC proliferation, angiogenesis, and spatial heterogeneity.
• Multi-b-value DWI may be a noninvasive method to assess HCC therapeutic efficacy.

Graphical Abstract
Co-occurrence of delayed language development and autism spectrum disorder in children with metabolic disorders
Authors: Abdel-hakim Azza Samy , Abdel-wareth Lamiaa Mohamed , Ghandoor Hassan Hosny , Shata Mennatallah Osama , Elrefaie Dina Ahmed 
Published: March 2024

Abstract
Background
Children with various metabolic disorders are considered a high-risk group for different developmental delays. Delayed language development (DLD) and autism spectrum disorder (ASD) have a common incidence in children with metabolic disorders which negatively impact their social and academic life. So, early assessment of this high-risk group for the presence of DLD and/or ASD is of great significance and providing better prognosis through starting therapy as early as possible.

Aim of the work
It aims to detect the presence of DLD and ASD among children with metabolic disorders.

Methods
This is an analytical (observational) cross-sectional study. The subjects of this study comprised a convenient sample of 100 children diagnosed as having different metabolic disorders with age range between 24 and 48 months. The Modified Preschool Language Scale, Fourth Edition–Arabic version and the Childhood Autism Rating Scale were applied for all children, to detect the presence of DLD and ASD.

Results
Assessment of 100 children with unequal distribution of 13 types of metabolic disorders found that 86% of cases had DLD and 16% had ASD. Regarding different metabolic disorders, we found both DLD and ASD in nine types and only DLD in four types of metabolic disorders.

Conclusion
Children with metabolic disorders are at a high risk for DLD and ASD. Early detection of these cases provides early intervention and better outcome.
Mental health at work: societal, economic and health imperatives align; it's time to act
Authors: Minshall Darren , Tracy Derek K. , Tarn Mark , Greenberg Neil 
Published: March 2024

SummaryThe enormous impact of mental illness on work and productivity is a global challenge, with immense costs to wider society. Now is the time for action, with new international guidelines and an emergent consensus on occupational mental healthcare. Alongside governments, organisations and employers, psychiatrists have a leading role to play.
The Global Anesthesia Workforce Survey: Updates and Trends in the Anesthesia Workforce
Authors: Law Tyler J. , Lipnick Michael S. , Morriss Wayne , Gelb Adrian W. , Mellin-Olsen Jannicke , Filipescu Daniela , Rowles Jackie , Rod Pascal , Khan Fauzia , Yazbeck Patrica , Zoumenou Eugene , Ibarra Pedro , Ranatunga Kumudini , Bulamba Fred ,   Collaborators
Published: March 2024

BACKGROUND:
There is a large global deficit of anesthesia providers. In 2016, the World Federation of Societies of Anaesthesiologists (WFSA) conducted a survey to count the number of anesthesia providers worldwide. Much work has taken place since then to strengthen the anesthesia health workforce. This study updates the global count of anesthesia providers.

METHODS:
Between 2021 and 2023, an electronic survey was sent to national professional societies of physician anesthesia providers (PAPs), nurse anesthetists, and other nonphysician anesthesia providers (NPAPs). Data included number of providers and trainees, proportion of females, and limited intensive care unit (ICU) capacity data. Descriptive statistics were calculated by country, World Bank income group, and World Health Organization (WHO) region. Provider density is reported as the number of providers per 100,000 population.

RESULTS:
Responses were obtained for 172 of 193 United Nations (UN) member countries. The global provider density was 8.8 (PAP 6.6 NPAP 2.3). Seventy-six countries had a PAP density <5, whereas 66 countries had a total provider density <5. PAP density increased everywhere except for high- and low-income countries and the African region.

CONCLUSIONS:
The overall size of the global anesthesia workforce has increased over time, although some countries have experienced a decrease. Population growth and differences in which provider types that are counted can have an important impact on provider density. More work is needed to define appropriate metrics for measuring changes in density, to describe anesthesia cadres, and to improve workforce data collection processes. Effort to scale up anesthesia provider training must urgently continue.
Effect of Water Temperature and Salinity on the Jet Erosion Test (JET) Discharge Coefficient
Authors: Quiah Joanna , Bolinaga Celso Castro , Hall Steven G. , Fox Garey A. , Stark Nina 
Published: March 2024

Highlights

The JET discharge coefficient Cd
was negatively correlated to water temperature and positively correlated to salinity.

The impact of water temperature was more significant than that of salinity, especially at lower temperatures.

Increasing water temperatures reduced Cd
by as much as 20% per 10°C increment.

Low levels of salinity initially increased Cd
, but its magnitude remained relatively constant for levels greater than 5 ppt.

Abstract. The discharge coefficient (Cd) of the Jet Erosion Test (JET) directly affects the calculation of applied shear stresses (to) during testing and, therefore, of JET-derived erodibility parameters, namely, the soil’s critical shear stress (tc) and erodibility coefficient (kd). Typically, Cd is assumed to be constant for a given combination of JET device (e.g., original vs. mini) and setup (e.g., head tank vs. pressure gage), disregarding the effects of varying environmental conditions. The objective of this study was to quantify the impact of changing water temperature and salinity on the Cd of a mini-JET device fed by a pressure head tank. Laboratory experiments were conducted to determine the variability in Cd for ranges of water temperature between 10 and 30°C and salinity between 0 and 35 ppt. Results showed that Cd was sensitive to changes in both variables, with water temperature generating a more significant impact. Cd was negatively correlated to water temperature, decreasing by as much as 20% when temperature increased from 10 to 20°C, and positively correlated to salinity, increasing at low levels but remaining relatively constant for levels greater than 5 ppt. When extrapolated to erosion curves and JET-derived erodibility parameters, the variability in Cd significantly impacted the calculation of to and the magnitude of tc and kd, highlighting the degree of uncertainty that could be associated with these variables because of an uncalibrated Cd. Lastly, results from the laboratory experiments were used to develop a normalized predictive model and associated curves for application to other mini-JET devices with similar setups. Keywords: Discharge Coefficient, Erodibility, Jet Erosion Test, Salinity, Temperature.
Free-space coupled, large-active-area superconducting microstrip single-photon detector for photon-counting time-of-flight imaging
Authors: Wang Yu-Ze , Zhang Wei-Jun , Zhang Xing-Yu , Xu Guang-Zhao , Xiong Jia-Min , Chen Zhi-Gang , Hong Yi-Yu , Liu Xiao-Yu , Yuan Pu-Sheng , Wu Ling , Wang Zhen , You Li-Xing 
Published: March 2024

Numerous applications at the photon-starved regime require a free-space coupling single-photon detector with a large active area, low dark count rate (DCR), and superior time resolutions. Here, we developed a superconducting microstrip single-photon detector (SMSPD), with a large active area of 260 µm in diameter, a DCR of ∼5kcps, and a low time jitter of ∼171ps, operated at a near-infrared of 1550 nm and a temperature of ∼2.0K. As a demonstration, we applied the detector to a single-pixel galvanometer scanning system and successfully reconstructed the object information in depth and intensity using a time-correlated photon counting technology.
Shock indices are associated with in-hospital mortality among patients with septic shock and normal left ventricular ejection fraction
Authors: Lee Kyu Jin , Kim Yong Kyun , Jeon Kyeongman , Ko Ryoung-Eun , Suh Gee Young , Oh Dong Kyu , Lim Sung Yoon , Lee Yeon Joo , Lee Su Yeon , Park Mi-Hyeon , Lim Chae-Man , Park Sunghoon ,   on behalf of the Korean Sepsis Alliance (KSA) investigators
Published: March 2024

Background
The understanding of shock indices in patients with septic shock is limited, and their values may vary depending on cardiac function.

Methods
This prospective cohort study was conducted across 20 university-affiliated hospitals (21 intensive care units [ICUs]). Adult patients (≥19 years) with septic shock admitted to the ICUs during a 29-month period were included. The shock index (SI), diastolic shock index (DSI), modified shock index (MSI), and age shock index (Age-SI) were calculated at sepsis recognition (time zero) and ICU admission. Left ventricular (LV) function was categorized as either normal LV ejection fraction (LVEF ≥ 50%) or decreased LVEF (<50%).

Results
Among the 1,194 patients with septic shock, 392 (32.8%) who underwent echocardiography within 24 h of time zero were included in the final analysis (normal LVEF: n = 246; decreased LVEF: n = 146). In patients with normal LVEF, only survivors demonstrated significant improvement in SI, DSI, MSI, and Age-SI values from time zero to ICU admission; however, no notable improvements were found in all patients with decreased LVEF. The completion of vasopressor or fluid bundle components was significantly associated with improved indices in patients with normal LVEF, but not in those with decreased LVEF. In multivariable analysis, each of the four indices at ICU admission was significantly associated with in-hospital mortality (P < 0.05) among patients with normal LVEF; however, discrimination power was better in the indices for patients with lower lactate levels (≤ 4.0 mmol/L), compared to those with higher lactate levels.

Conclusions
The SI, DSI, MSI, and Age-SI at ICU admission were significantly associated with in-hospital mortality in patients with septic shock and normal LVEF, which was not found in those with decreased LVEF. Our study emphasizes the importance of interpreting shock indices in the context of LV function in septic shock.
Effect of Lactobacillus casei and Garlic Powder Administration on Broiler Performance, Immune Response and Blood Profile
Authors: Mangisah Istna , Yunianto V D , Sumarsih S , Sugiharto S 
Published: March 2024

This study aimed to examine effect of giving a mixture of Lactobacillus casei and garlic powder (LGP) on broiler performance, immune response and blood profile. One hundred and forty-day old broilers with an average body weight of 43.70 Â± 0.88 g were placed randomly in 20 experimental units. Completely randomized design was used in this study, with 4 treatments and 5 replications. The treatment was conducted when the chickens were 22-35 days old (finisher phase). The chickens were given a mixture of Lactobacillus casei and garlic powder (LGP) at concentration levels of: 0, 1, 2, andÂ 3%. Parameters measured were blood profile, weight of lymphoid organs (bursa of Fabricius, spleen, and thymus), and carcass production. Data were analyzed for variance and if there was a significant effect, then Duncanâ€™s multiple range test was followed at the 5% level. Results showed that the administration of LGP improved the immune response, carcass weight and final body weight of broiler chickens. The administration of 3% LGP improved immune response and achieved the best broiler performance.
Household Consumers Perception towards Frozen Beef
Authors: Apriantini Astari , Arief Irma Isnafia , ENSD Lucia Cyrilla 
Published: March 2024

Demand of beef in Indonesia is higher compared to the domestic beef supply, hence the Indonesian government has established policy to import frozen beef from other countries in order to support the high demand of Indonesia people. However, mosf of Indonesian people prefer to purchase fresh meat (freshly slaughtered beef) rather than frozen beef. The aims of this study were to identify the characteristics of household consumers who bought beef meat and their perceptions towards frozen beef; including to analyze the relationship between perceptions and consumer characteristics of frozen beef, and to analyze the consumer behavior in making decision to buy frozen beef in Bogor area and DKI Jakarta. Total about 200 households were directly interviewed using structured questionnaire. The questionnaires includes general characteristics of respondents (age, education level, occupation, income, number of family member), purchasing behavior which was analyzed descriptively, and respondents perceptions toward frozen beef which was analyzed by calculating the average value of perception and then categorized based on the level of perception category. Results showed that consumerâ€™s perceptions toward frozen beef according to several aspects had a low score (average final score 2.37), indicated that consumers had a poor perceptions towards frozen beef. Furthermore, most of the respondents who buy beef were housewives who buy meat in traditional markets which only provide fresh meat, they assumed that fresh meat had very good quality because the meat came from slaughtered beef.Â Those respondents think that freezing causes negative effects on beef, freezing treatment reduce the quality such as changes of meat color and flavour; and reduce nutritional content of beef. Â It was discovered that socialization about frozen beef and the process of handling frozen meat is required for household consumers to control the quality of beef as well as to increase the consumerâ€™s trusts in purchasing frozen beef.
Performances of Post-weaned Pasundan Calves Fed Extra Diets in an Extensive Grazing System
Authors: Kardaya Dede , Sudrajat Deden , Wahyuni Dewi 
Published: March 2024

Changing from the pre-weaning to the post-weaning period is a transition from liquid to solid feed accompanied by a dramatic transformation of the GI tract.Â Supplemental solid feeding of grazing post-weaning calves is expected to improve their productivity.Â The study aimed to determine the effect of extra diet on the performances of post-weaned Pasundan calves (15 males and 15 females) that were grazed, using a completely randomized design of 2x3 factorials (two sex factors x three diet factors).Â The diet treatments were that post-weaned Pasundan calves were grazed: without being given extra diets (grazing/control), extra diets without urea-impregnated zeolite (extra diet-1), and extra diets with urea-impregnated zeolite (extra diet-2).Â The parameters were diet consumption (only for extra diets, unmeasured grazing consumption), body weights, and body condition.Â The data were analyzed with GLM Univariate.Â The results showed: The interaction between diet treatment and sex did not affect all the observed parameters.Â Consumption of extra diet-1 (529.37Â±3.06 g DM/head/day) was higher (P0.05) than extra diet-2 consumption (525.17Â±1.96 g DM/head/day), but after a correction of body weight, the result was no different. Â Sex factors did not affect all observed parameters.Â The ADG of post-weaned calves fed extra diet-1 (155.8Â±27.5 g), or extra-2 diet (124.2Â±56.3 g) was higher (P0.05) than the grazing (66.67Â±35.8 g).Â The extra diet-1 produced a higher change in body condition (1.8Â±0.78, P0.05) than extra diet-2 or grazing (1.2Â±0.42).Â In conclusion, feeding extra diet-1 to post-weaned Pasundan calves increased ADG by 234% and improved the body condition by 150% better than calves that were only grazed in an extensive grazing system.