bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studying the role of cortisol in the pathogenesis of atopic dermatitis during pregnancy
Authors: Kandrashkina Ju. A. , Orlova E. A. , Kostina E. M. 
Published: March 2024

Introduction. Atopic dermatitis (AD) is one of the most common dermatitis, characterized by complex pathogenetic mechanisms. Psychological stress is recognized as one of the triggers of AD. Stress causes a high release of cortisol and epinephrine or norepinephrine, stimulating the immune system, primarily T helper cells type 1 (Th1 cells), to produce pro-inflammatory cytokines, leading to a cellular immune response and inflammation. In recent years, there has been an increase in incidence among pregnant women, however, the specific mechanisms of the development of AD during pregnancy still remain poorly understood. Aim. To study the role of cortisol in AD during pregnancy.Materials and methods. The study included 76 pregnant women during an exacerbation of AD, 20 non-pregnant women during an exacerbation of AD, 20 non-pregnant women without AD, 20 pregnant women without AD. The severity of AD was determined using the SCORAD index. Cortisol levels were determined in blood serum using enzyme-linked immunosorbent assay (ELISA). Anxiety level was determined using the Beck Anxiety Inventory. The level of itching was determined using a 5D itching scale.Results. Cortisol levels in pregnant women with AD (629.8 pg/ml) were significantly higher than in non-pregnant women with AD (386.15 pg/ml) (p < 0.05). Cortisol levels were correlated with the severity level (Spearman coefficient = 0.203, p = 0.018), anxiety level (Spearman coefficient = 0.411, p = 0.001), and level of itching (Spearman coefficient = 0.352, p = 0.001).Conclusions. Cortisol is important in the pathogenesis of AD during pregnancy. During pregnancy with exacerbation of AD, higher values were observed than outside pregnancy.
Therapy of netakimab in nail psoriasis
Authors: Kurdina M. I. , Kolenko N. G. 
Published: March 2024

Introduction. The nail psoriasis severity does not always correspond to the skin process intensity, but often correlates with a more severe, prolonged and aggressive course of the disease.Materials and methods. 48 adult patients (n = 48) with nail psoriasis were under observation. The severity of the psoriatic lesion of the nails was determined using the NAPSI index (Nail Psoriasis Severity Index). The assessment was carried out before the start of treatment, in the first week, and then every 4 weeks up to and including 52 weeks. The Dermatological Quality of Life Index (DLQI) were determined by questionnaires before the start of treatment, at the 12th and 52nd weeks. All patients on an outpatient basis received netakimab monotherapy at a dose of 120 mg in the form of two subcutaneous injections of 1 ml (60 mg) of the drug, each administered once a week at weeks 0, 1 and 2, then 1 time every 4 weeks. The total duration of treatment for each patient was 52 weeks. The safety of netakimab was evaluated based on the development of adverse events and local reactions to the administration of the drug.Results. The results of the study for 52 weeks showed high efficacy of netakimab. Average NAPSI score improved – 33.1% by the week 12 of treatment and – 72.3% by the week 52 compared to baseline, the quality of their life improved. During the 52 weeks of the study, there were no cases of early withdrawal due to adverse events and cases of serious adverse events.Conclusion. Based on the study results we recommend netakimab for medical use among patients with moderate and severe nail psoriasis.
Proficiency of probability distributions in unit hydrograph derivation
Authors: Sangin Esmatullah , Patil Pravin R. , Mishra S. K. , Sen Sumit 
Published: March 2024

Abstract

The probability distribution function (PDF)-based unit hydrographs (UHs) are gaining momentum in an application for more accurate rainfall-runoff transformation. Employing seven statistical performance indices, R2, NSE, MSE, RMSE, MAE, MAPE, and SE in generalized reduced gradient nonlinear programming (GRG-NLP) optimization, 18 known and 12 adaptable PDF-based UHs were assessed against UHs derived from 18 storms in 7 basins across the United States, Turkey, and India. To this end, 27 Maple codes were proposed for UH-application requiring only peak discharge (qp), time to peak (tp), and time base (tb) for derivation. The introduced PDFs, such as Dagum, Generalized Gamma, Log-Logistic, Gumbel Type-I, and Shifted Gompertz, replicated the observed data-derived UHs more closely than did the known PDFs, like Inverse Gaussian, two-parameter gamma distribution (2-PGD), Log-Normal, Inverse-Gamma, and Nagakami. Among the three-parameter (6 nos.), two-parameter (21 nos.), and single-parameter (3 nos.) PDFs, the Dagum, Log-Logistic, and Poisson consistently outperformed their respective counterparts in replication.
Experiences of a Community-Based Digital Intervention Among Older People Living in a Low-Income Neighborhood: Qualitative Study
Authors: Lu Si Yinn , Yoon Sungwon , Yee Wan Qi , Heng Wen Ngiam Nerice , Ng Kennedy Yao Yi , Low Lian Leng 
Published: March 2024

Background
Older adults worldwide experienced heightened risks of depression, anxiety, loneliness, and poor mental well-being during the COVID-19 pandemic. During this period, digital technology emerged as a means to mitigate social isolation and enhance social connectedness among older adults. However, older adults’ behaviors and attitudes toward the adoption and use of digital technology are heterogeneous and shaped by factors such as age, income, and education. Few empirical studies have examined how older adults experiencing social and economic disadvantages perceive the learning of digital tools.

Objective
This study aims to examine the motivations, experiences, and perceptions toward a community-based digital intervention among older adults residing in public rental flats in a low-income neighborhood. Specifically, we explored how their attitudes and behaviors toward learning the use of smartphones are shaped by their experiences related to age and socioeconomic challenges.

Methods
This study adopted a qualitative methodology. Between December 2020 and March 2021, we conducted semistructured in-depth interviews with 19 participants aged ≥60 years who had completed the community-based digital intervention. We asked participants questions about the challenges encountered amid the pandemic, their perceived benefits of and difficulties with smartphone use, and their experiences with participating in the intervention. All interviews were audio recorded and analyzed using a reflexive thematic approach.

Results
Although older learners stated varying levels of motivation to learn, most expressed ambivalence about the perceived utility and relevance of the smartphone to their current needs and priorities. While participants valued the social interaction with volunteers and the personalized learning model of the digital intervention, they also articulated barriers such as age-related cognitive and physical limitations and language and illiteracy that hindered their sustained use of these digital devices. Most importantly, the internalization of ageist stereotypes of being less worthy learners and the perception of smartphone use as being in the realm of the privileged other further reduced self-efficacy and interest in learning.

Conclusions
To improve learning and sustained use of smartphones for older adults with low income, it is essential to explore avenues that render digital tools pertinent to their daily lives, such as creating opportunities for social connections and relationship building. Future studies should investigate the relationships between older adults’ social, economic, and health marginality and their ability to access digital technologies. We recommend that the design and implementation of digital interventions should prioritize catering to the needs and preferences of various segments of older adults, while working to bridge rather than perpetuate the digital divide.
Effect of Prosocial Behaviors on e-Consultations in a Web-Based Health Care Community: Panel Data Analysis
Authors: Liu Xiaoxiao , Guo Huijing , Wang Le , Hu Mingye , Wei Yichan , Liu Fei , Wang Xifu 
Published: March 2024

Background
Patients using web-based health care communities for e-consultation services have the option to choose their service providers from an extensive digital market. To stand out in this crowded field, doctors in web-based health care communities often engage in prosocial behaviors, such as proactive and reactive actions, to attract more users. However, the effect of these behaviors on the volume of e-consultations remains unclear and warrants further exploration.

Objective
This study investigates the impact of various prosocial behaviors on doctors’ e-consultation volume in web-based health care communities and the moderating effects of doctors’ digital and offline reputations.

Methods
A panel data set containing information on 2880 doctors over a 22-month period was obtained from one of the largest web-based health care communities in China. Data analysis was conducted using a 2-way fixed effects model with robust clustered SEs. A series of robustness checks were also performed, including alternative measurements of independent variables and estimation methods.

Results
Results indicated that both types of doctors’ prosocial behaviors, namely, proactive and reactive actions, positively impacted their e-consultation volume. In terms of the moderating effects of external reputation, doctors’ offline professional titles were found to negatively moderate the relationship between their proactive behaviors and their e-consultation volume. However, these titles did not significantly affect the relationship between doctors’ reactive behaviors and their e-consultation volume (P=.45). Additionally, doctors’ digital recommendations from patients negatively moderated both the relationship between doctors’ proactive behaviors and e-consultation volume and the relationship between doctors’ reactive behaviors and e-consultation volume.

Conclusions
Drawing upon functional motives theory and social exchange theory, this study categorizes doctors’ prosocial behaviors into proactive and reactive actions. It provides empirical evidence that prosocial behaviors can lead to an increase in e-consultation volume. This study also illuminates the moderating roles doctors’ digital and offline reputations play in the relationships between prosocial behaviors and e-consultation volume.
Performance of GPT-4V in Answering the Japanese Otolaryngology Board Certification Examination Questions: Evaluation Study
Authors: Noda Masao , Ueno Takayoshi , Koshu Ryota , Takaso Yuji , Shimada Mari Dias , Saito Chizu , Sugimoto Hisashi , Fushiki Hiroaki , Ito Makoto , Nomura Akihiro , Yoshizaki Tomokazu 
Published: March 2024

Background
Artificial intelligence models can learn from medical literature and clinical cases and generate answers that rival human experts. However, challenges remain in the analysis of complex data containing images and diagrams.

Objective
This study aims to assess the answering capabilities and accuracy of ChatGPT-4 Vision (GPT-4V) for a set of 100 questions, including image-based questions, from the 2023 otolaryngology board certification examination.

Methods
Answers to 100 questions from the 2023 otolaryngology board certification examination, including image-based questions, were generated using GPT-4V. The accuracy rate was evaluated using different prompts, and the presence of images, clinical area of the questions, and variations in the answer content were examined.

Results
The accuracy rate for text-only input was, on average, 24.7% but improved to 47.3% with the addition of English translation and prompts (P<.001). The average nonresponse rate for text-only input was 46.3%; this decreased to 2.7% with the addition of English translation and prompts (P<.001). The accuracy rate was lower for image-based questions than for text-only questions across all types of input, with a relatively high nonresponse rate. General questions and questions from the fields of head and neck allergies and nasal allergies had relatively high accuracy rates, which increased with the addition of translation and prompts. In terms of content, questions related to anatomy had the highest accuracy rate. For all content types, the addition of translation and prompts increased the accuracy rate. As for the performance based on image-based questions, the average of correct answer rate with text-only input was 30.4%, and that with text-plus-image input was 41.3% (P=.02).

Conclusions
Examination of artificial intelligence’s answering capabilities for the otolaryngology board certification examination improves our understanding of its potential and limitations in this field. Although the improvement was noted with the addition of translation and prompts, the accuracy rate for image-based questions was lower than that for text-based questions, suggesting room for improvement in GPT-4V at this stage. Furthermore, text-plus-image input answers a higher rate in image-based questions. Our findings imply the usefulness and potential of GPT-4V in medicine; however, future consideration of safe use methods is needed.
ORIENTASI KELEKATAN DAN REAKSI DUKA CITA AKIBAT KEMATIAN HEWAN PELIHARAAN
Authors: Fitriyana Risa Nur 
Published: March 2024

Memelihara hewan merupakan aktivitas umum yang dilakukan oleh manusia. Peningkatan jumlah kepemilikan hewan peliharaan berdampak pada peningkatan jumlah pemilik hewan peliharaan yang mengalami kehilangan hewan peliharaan akibat kematian. Kematian hewan peliharaan keberadaannya dinilai dapat memenuhi fungsi dasar kelekatandan berperan sebagai figur kelekatan akan menimbulkan reaksi duka cita bagi pemiliknya. Penelitian ini menguji pengaruh orientasi kelekatan cemasdan orientasi kelekatan menghindarterhadap reaksi duka cita akibat kematian hewan peliharaan. Subjek penelitian yang hewan peliharaannya mati dalam 2 tahun terakhir (N = 159) mengisi skala Pet Attachment Questionnaire dan Core Bereavement Items. Orientasi kelekatan cemasdan orientasi kelekatan menghindarmemiliki pengaruh signifikan terhadap reaksi duka cita akibat kematian hewan peliharaan (F = 22,234, p < 0,001), akan tetapi kontribusi yang diberikan kecil (adj. R2 = 0,213). Sebesar 21,3% variasi reaksi duka cita dipengaruhi oleh orientasi kelekatan cemasdan orientasi kelekatan menghindar.Orientasi kelekatan cemas berpengaruh lebih besar pada reaksi duka cita akibat kematian hewan peliharaan.Kata kunci: Orientasi kelekatan cemas, orientasi kelekatan menghindar, reaksi duka citaRaising animals is part of daily activities. More and more people own a pet. And as the pets died, the owner might feel remorse and grief. The death of a pet is considered to meet the basic functions of attachment as the pet served as an attachment figure.This research examined the impact of pet anxiety attachment and pet avoidant attachment toward grief over the loss of a pet. Participants whose companion animal died within past 2 years (N = 159) completed the Pet Attachment Questionnaire and Core Bereavement Items. Both pet anxiety attachment and pet avoidant attachment were found to impacted subjectss’ grief. The result’s contribution was statistically significant (F = 22,234, p < 0,001) but relatively low (adj. R2 = 0,213). Results indicated that 21,3% of the variance in grief can be accounted for the linear combination of pet anxiety attachment and pet avoidant attachment. Furthermore, the pet anxiety attachment’s contribution toward grief were higher. Keywords : Pet anxiety attachment, pet avoidant attachment, grief
Improving critical thinking and creative thinking skills through POPBL learning in high school student
Authors: Suwistika Rima , Ibrohim I. , Susanto Hendra 
Published: March 2024

Education in the 21st century has experienced many advances that are adjusted to the demands of the times. Thinking skills are in high demand in the 21st century, especially critical thinking and creative thinking skills for students. This study aims to determine the effectiveness of POPBL model learning in improving critical and creative thinking skills of high school students. This type of quasi-experimental research was carried out with a nonequivalent control group design. The population of this study was students of class XI MIPA SMAN 1 Cluring with two classes XI MIPA 1 and XI MIPA 2 as samples. The data collection method is in the form of tests of critical thinking skills and creative thinking. The data analysis used is an analysis of covariance test. The results showed that POPBL was effective in improving the critical thinking and creative thinking skills of SMAN 1 Cluring students. The implementation of POPBL learning shows interaction between students at work as well.
The effectiveness of collaborative learning on civic education problem-solving abilities based on cognitive styles
Authors: Sucipto S. , Setiawan Windi , Hatip Ahmad 
Published: March 2024

Problem-solving ability is one of the competencies that individuals must have as a provision to face increasingly complex problems. This study aims to determine the effect of the application of the Collaborative Learning (CL) model on the problem-solving ability of civic education based on the cognitive style of students. This study applies the quantitative research paradigm with a quasi-experimental design. The research subjects were 162 students selected by cluster random sampling technique from two private universities in Surabaya, Indonesia. Data collection techniques use Cognitive Style Inventory (CoSI) and Problem Solving Inventory (PSI). The data were analyzed using an independent sample t test technique with SPSS software. The results showed that the application of the CL model had a significant effect on the problem-solving ability of civic education in students. The field independent (FI) cognitive style shows higher problem-solving ability than the field dependent (FD) in both the application of the CL model and the Cooperative Learning (CpL) model. In the learning process, it is recommended that educators apply the CL model as an alternative in improving the problem-solving ability of civic education by paying attention to the cognitive style of students.
Safety and cost effectiveness of immediate sequential bilateral cataracts surgery
Authors: Bowman Miles , Bauer Abbie R 
Published: March 2024

A clinical decision report using:
Rush SW, Gerald AE, Smith JC, Rush AJ, Rush RB. Prospective analysis of outcomes and economic factors of same-day bilateral cataract surgery in the United States. Journal of Cataract and Refractive Surgery. 2015;41(4):732-739. https://doi.org/10.1016/j.jcrs.2014.07.034
for a patient with bilateral cataracts.
Effects of chaplain care on coping with cancer
Authors: Battiston Sarah , Baughan Scott L 
Published: March 2024

A clinical decision report using:
Piderman KM, Radecki CR, Jenkins SM, et al. Hearing and heeding the voices of those with advanced illnesses. Journal of Palliative Care. 2020;35(4):248-255. https://doi.org/10.1177/0825859720928623
for a patient having difficulty coping with cancer.
Buprenorphine for pain management vs. chronic hydrocodone-acetaminophen therapy when comorbidities increase the risk of opioid-related side effects
Authors: Zhao Jessica , Kim Doo Hee 
Published: March 2024

A clinical decision report using:
Gordon A, Callaghan D, Spink D, et al. Buprenorphine transdermal system in adults with chronic low back pain: a randomized, double-blind, placebo-controlled crossover study, followed by an open-label extension phase. Clin Ther. 2010;32(5):844-860. https://doi.org/10.1016/j.clinthera.2010.04.018
for a patient on long-term opioid therapy with high risk factors for adverse effects
PENGEMBANGAN LEMBAR KERJA SISWA BERBASIS TEMATIK TERPADU KURIKULUM 2013 UNTUK KELAS I SEKOLAH DASAR
Authors: Zulharmansyah Zulharmansyah 
Published: March 2024

AbstractÂ This Â research Â is Â a Â research Â and Â development Â study Â on Â Thematic Â learning Â in Â one Â grade Â elementary schools. Â This research Â and development Â is carried out Â in stages: Â potential problems, Â collecting data, product design, design validation, design revisions, trials, product revisions, usage trials. This study aims to: (1) produceÂ Thematic Â learning Â based student worksheets suitable for class I thematic learning; (2) and find out Â the Â effectiveness of the Â application of Thematic Â learning Â based Student Â Worksheets through Â pretest Â and posttest. Data collection was carried out at SD Negeri Rejodadi 01 and SD Negeri Rejodadi 04. The research phase is to define, design, develop and disseminate. The level of eligibility of student worksheets was obtained from expert validators and practitioner validators analyzed. After being validated and revised, the product is tested on Â a Â limited Â basis Â on Â students. Â The Â results Â of Â the Â limited Â trial Â are Â then Â analyzed Â to Â determine Â the feasibility Â of Â the Â student Â worksheet Â from Â the Â student's Â perspective.Keywords: LKS, thematic, Multimedia, curriculum 2013AbstrakPenelitian ini adalah penelitian pengembangan (Research and Development) pada pembelajaran Tematik di Sekolah Dasar (SD) kelas I. Penelitian dan pengembangan ini dilakukan dengan tahapan: potensi masalah, mengumpulkan data, desain produk, validasi desain, revisi desain, uji coba, revisi produk, uji coba pemakaian. Penelitian ini bertujuan untuk: (1) menghasilkan lembar kerja siswa berbasis karakter yang Â cocok Â digunakan Â untuk Â pembelajaran Â tematik Â kelas Â III; Â (2) Â dan Â mengetahui Â efekrivitas Â dari penerapan Lembar Kerja Peserta Didik berbasis karakter melalui pretes dan postes. pengambilan data dilakukan di SD Negeri Rejodadi 01 dan SD Negeri Rejodadi 04. Fase penelitian adalahÂ Â mendefinisikan,Â Â merancang, mengembangkan, dan menyebarluaskan. Tingkat kelayakan lembar kerja siswa diperoleh dari validator ahli Â dan Â validator Â praktisi Â yang dianalisis. Â Setelah Â divalidasi Â dan Â direvisi, Â produk Â diuji Â secara Â terbatas pada siswa. Hasil uji coba terbatas kemudian dianalisis untuk menentukan kelayakan lembar kerja siswa dari sudut pandang siswa.Â Kata Kunci: LKS, Tematik, kurikulum 2013
PENERAPAN PEMBELAJARAN SPRINT GAWANG UNTUK MENUMBUHKAN KEBERANIAN, KESENANGAN DAN PERCAYA DIRI DALAM PEMBELAJARAN PADA SISWA KELAS IV SDN JATIBARU
Authors: Suherman Suherman 
Published: March 2024

Penelitian ini dilatarbelakangi oleh data observasi yang menunjukkan perolehan hasil belajar siswa pada pelajaran olahraga dan jasamani Â sangat rendah. Untuk merespon hal itu maka peneliti melakukan penelitian tindakan kelas yang bertujuan untuk meningkatkan hasil belajar siswa. Tujuan yang hendak dicapai pada penelitian ini antara lain ; 1) Membuat pengembangan untuk menumbuhkan keberanian dalam pembelajaran sprint gawang pada siswa kelas 4. 2) Membuat pengembangan untuk menumbuhkan kesenangan dalam pembelajaran sprint gawang pada siswa kelas 4.Â 3) Membuat pengembangan untuk menumbuhkan percaya diri dalam pembelajaran sprint gawang pada siswa kelas 4.Â Â Â Â Â Penelitian ini dilakukan pada kelas 4 SDN Jatibaru dengan jumlah siswa sebanyak 32 orang. Penelitian ini mengukur seluruh ranah yang ada pada hasil belajar, yaitu : kognitif (pemahaman), afektif (penerimaan dan respin) dan psikomotor (keterampilan meniru). Hasil penelitian menunjukan peningkatan pada setiap ranah ditiap siklusnya. Dengan metode pembelajaran Sprint Gawang siswa mendapatkan pengalaman belajar langsung sehingga pembelajaran lebih menarik dan dapat meningkatkan hasil belajar siswa. Dari data maka direkomendasikan kepada para guru untuk menggunakan metode pembelajaran Sprint Gawang dalam pembelajaran Olahraga dan Jasmani di SD Jatibaru untuk meningkatkan hasil belajar siswa.Â