bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of photovoltaic generation penetration effect on the maximum loadability of the system
Authors: Gupta Santosh Kumar , Ranjan Ashish , Kumar Dhananjay , Yadav Lokesh Kumar , Rahman Md Atiqur , Kumar Vikash , Kumar Neeraj 
Published: March 2024

Abstract
This paper proposed a method to investigate the effect of increasing PV penetration on the voltage stability of an IEEE 14-bus test system considering maximum PV penetration and system loadability limit. The critical bus of the test system has been decided based on nose curve analysis. The solar PV system is deployed with the most critical bus of the system. The effect of increasing PV penetration on the improvement in the loading capacity of various power system components like transmission lines, transmission line transformers, and generators is investigated over the adopted test system. Based on solar PV penetration up to 100 MW, the maximum loadability limit of the IEEE 14-bus test system increases, as shown by the results. Bus 14 is found to be the most severe bus of the test system using the continuation power flow (CPF) method. However, in some cases, overloading situations develop after a certain limit of PV penetration in the power system. In this condition, the overloading of the power system equipment is improved by the use of a Static Synchronous Compensator (STATCOM) at bus number 14, a double circuit line in the critical line (9–14), and Static Synchronous Series Compensator (SSSC) in the most severe line (9–14) in the system. The maximum loadability of the system gets maximum enhanced from 4.0349 p.u. to 4.5602 p.u. under simultaneous use of solar PV generation, SSSC, and STATCOM at the most critical bus and in most severe line of the system. As evidence, the enhancement in maximum loadability of the system found using the proposed method has been also compared with the existing research. The maximum system loadability has been also enhanced under normal and (N-1) contingency conditions by the use of PV penetration in the system. PSAT/MATLAB software is used for simulation and maximum loadability has been investigated by continuation power flow (CPF) method.
Perambulations in Print
Authors: Bascom Ben 
Published: March 2024

Abstract
This chapter examines the only remaining copy of Jonathan Plummer’s life narrative (1796–1798) to argue that his local notoriety as a “hermaphrodite”—a charge he disseminated through his public declamations that he circulated in print—articulates a masculinity in conflict with the norms he actively tried to meet. After being established as a poet through the patronage of the eccentric “Lord” Timothy Dexter (examined in Chapter 3), Plummer proceeded to narrate how his dreams and his hearing of divine voices set him apart from the masses. This chapter focuses on how Plummer’s example disturbs a series of norms regarding print—specifically, its connection to constituting privacy—that inform scholarly writings on the public sphere.
Coda
Authors: Bascom Ben 
Published: March 2024

Abstract
The Coda turns to contemporary fantasies regarding monumentalizing masculinity (Donald Trump) and the shadow of Benjamin Franklin. In many ways, Franklin was a larger-than-life eccentric, one whose written life became abstracted into a model for other (white) men to mimic to secure their “way to wealth.” The way Franklin’s textual life writing becomes a synecdoche—a part for a whole—of the U.S. nation shows how one individual’s becoming singular formed an abstract norm against which other lives are measured. Indeed, Franklin’s so-called autobiography is more of a hodgepodge result of four specific writing occasions over the course of nearly twenty years and posthumously manufactured into several iterations of a book. That achievement into book form stabilizes what becomes a norm of written self-production in the nineteenth century.
Direct-to-Implant vs Tissue Expander Placement in Immediate Breast Reconstruction: A Prospective Cohort Study
Authors: Chiang Sarah N , Keane Alexandra M , Ribaudo Joseph G , Tao Yu , Margenthaler Julie A , Tenenbaum Marissa M , Myckatyn Terence M 
Published: March 2024

Abstract

Background
Direct-to-implant (DTI) breast reconstruction after mastectomy has gained increasing popularity. While concerns over ischemic complications related to tension on the mastectomy flap persist, newer techniques and technologies have enhanced safety of this technique.

Objectives
To compare clinical and patient-reported outcomes of DTI and 2-stage tissue expander (TE) reconstruction.

Methods
A prospective cohort design was utilized to compare the incidence of reconstructive failure among patients undergoing DTI and TE reconstruction by unadjusted bivariate and adjusted multivariable logistic regression analyses. Secondary clinical outcomes of interest included specific complications requiring intervention (infection, seroma, hematoma, mastectomy flap necrosis, incisional dehiscence, device exposure) and time to final drain removal. Patient-reported outcomes on BREAST-Q were also compared.

Results
A total of 134 patients (257 breasts) underwent DTI reconstruction and 222 patients (405 breasts) received TEs. DTI patients were significantly younger with lower BMIs; less diabetes, hypertension, and smoking; and smaller breast sizes; they also underwent more nipple-sparing mastectomies with prepectoral reconstructions. Rates of any complication (18% DTI vs 24% TE, P = .047), reconstructive failure (5.1% vs 12%, P = .004), and seroma (3.9% vs 11%, P &lt; .001) were significantly lower in the DTI cohort on unadjusted analyses; however, there were no significant differences on adjusted regressions. Patient-reported satisfaction with breasts, psychosocial well-being, and sexual well-being were more substantively improved with DTI reconstruction.

Conclusions
Prepectoral DTI reconstruction is a viable option for postmastectomy reconstruction in carefully selected patients, with no significant increase in reconstructive failure or other complications.

Level of Evidence: 2
Human milk-specific fat components enhance the secretion of ghrelin by MGN3-1 cells
Authors: Kaneko Kentaro , Taniguchi Eriko , Funatsu Yui , Nakamura Yoshitaka , Iwakura Hiroshi , Ohinata Kousaku 
Published: March 2024

Abstract
Triacylglycerols (TAGs) are a major fat component in human milk. Since gastric lipase produces 1,2-diacylglycerol from TAGs, we focused on the bioactivity of human milk-derived diacylglycerols in stomach cells. Ghrelin is produced in the stomach and acts as an important regulator of growth hormone secretion and energy homeostasis. In this study, we showed that 1-oleoyl-2-palmitoylglycerol (OP) increased ghrelin secretion, whereas 1,3-dioleoyl-2-palmitoylglycerol (OPO), a major component of human milk TAGs, did not increase ghrelin secretion in the ghrelin-secreting cell line, MGN3-1. Therefore, diacylglycerol OP may directly contribute to the regulation of ghrelin secretion. We also found that 2-palmitoylglycerol and 1- and 2-oleoylglycerol increased ghrelin secretion. Finally, we demonstrated that intracellular cAMP levels and preproghrelin and ghrelin O-acyl transferase expression levels were enhanced by OP treatment in MGN3-1 cells. This may represent an example of a novel mother-infant interaction mediated by fat components derived from human breast milk.
Biodiesel production from waste cooking oil using calcium oxide derived from scallop shell waste
Authors: Puspitasari Poppy , Dwi Pramono Diki , Nur Fiansyah Davi , Ayu Permanasari Avita , Mufti Nandang , Abd Razak Jeefferie 
Published: March 2024

Abstract
Biodiesel is one of the alternative forms of diesel fuel and can be obtained using the transesterification process of waste cooking oil with a catalyst to accelerate the reaction. The heterogeneous catalyst from waste scallop shells is used due to its potential for being reused in the subsequent transesterification reactions. Heterogeneous catalysts can also be recycled, contributing to their environmentally friendly nature. This study aims to identify the performance of recycling a calcium oxide (CaO) catalyst from scallop shell waste on synthesis biodiesel. The method used is the transesterification method with the basic ingredients of waste cooking oil using a CaO catalyst. Then, after the transesterification process is complete, the catalyst is separated from the biodiesel and recycled to be reused in the transesterification process up to five times. The biodiesel samples obtained are identified for yield value, physico-chemical properties, thermal properties and performance. X-ray diffraction characterization results for the CaO catalyst show that it has a crystal size of 67.83 nm. Scanning electron microscope characterization shows that it has spherical particle shapes. Fourier transform infrared characterization shows the presence of Ca–O bonds. The highest biodiesel yield value of 74.23% is obtained in biodiesel Cycle 1. The flash point value of biodiesel samples ranges from 141.2°C to 149°C. Further, all of the biodiesel samples exhibit a cetane number of 75. The highest lower heating value of 38.22 MJ/kg is obtained in biodiesel Cycle 1 and the viscosity of the biodiesel samples ranges from 5.65 to 5.88 cSt. The density of the biodiesel samples ranges from 881.23 to 882.92 kg/m3. Besides, ester functional groups (C=O) and methyl functional groups have been successfully formed in all samples, with the methyl oleate compound observed as dominating the biodiesel samples. The cloud point value of the biodiesel samples ranges from 12°C to 13°C, and their pour point value ranges from 10°C to 12°C. The lead content in biodiesel is 0.8826 mg/kg. The lowest sulphur content is obtained from biodiesel Cycles 1 and 2 at 0.005%. Performance tests show that biodiesel has lower torque and brake power values than commercial diesel fuel and higher specific fuel consumption values than commercial diesel fuel.
Population genetic analysis based on the polymorphisms mediated by transposons in the genomes of pig
Authors: Zong Wencheng , Zhao Runze , Wang Xiaoyan , Zhou Chenyu , Wang Jinbu , Chen Cai , Niu Naiqi , Zheng Yao , Chen Li , Liu Xin , Hou Xinhua , Zhao Fuping , Wang Ligang , Wang Lixian , Song Chengyi , Zhang Longchao 
Published: March 2024

Abstract
Transposable elements (TEs) mobility is capable of generating a large number of structural variants (SVs), which can have considerable potential as molecular markers for genetic analysis and molecular breeding in livestock. Our results showed that the pig genome contains mainly TE-SVs generated by short interspersed nuclear elements (51,873/76.49%), followed by long interspersed nuclear elements (11,131/16.41%), and more than 84% of the common TE-SVs (Minor allele frequency, MAF &gt; 0.10) were validated to be polymorphic. Subsequently, we utilized the identified TE-SVs to gain insights into the population structure, resulting in clear differentiation among the three pig groups and facilitating the identification of relationships within Chinese local pig breeds. In addition, we investigated the frequencies of TEs in the gene coding regions of different pig groups and annotated the respective TE types, related genes, and functional pathways. Through genome-wide comparisons of Large White pigs and Chinese local pigs utilizing the Beijing Black pigs, we identified TE-mediated SVs associated with quantitative trait loci and observed that they were mainly involved in carcass traits and meat quality traits. Lastly, we present the first documented evidence of TE transduction in the pig genome.
Real world performance of the 21st Century Cures Act population-level application programming interface
Authors: Jones James R , Gottlieb Daniel , McMurry Andrew J , Atreja Ashish , Desai Pankaja M , Dixon Brian E , Payne Philip R O , Saldanha Anil J , Shankar Prabhu , Solad Yauheni , Wilcox Adam B , Ali Momeena S , Kang Eugene , Martin Andrew M , Sprouse Elizabeth , Taylor David E , Terry Michael , Ignatov Vladimir , Mandl Kenneth D 
Published: March 2024

Abstract

Objective
To evaluate the real-world performance of the SMART/HL7 Bulk Fast Health Interoperability Resources (FHIR) Access Application Programming Interface (API), developed to enable push button access to electronic health record data on large populations, and required under the 21st Century Cures Act Rule.

Materials and Methods
We used an open-source Bulk FHIR Testing Suite at 5 healthcare sites from April to September 2023, including 4 hospitals using electronic health records (EHRs) certified for interoperability, and 1 Health Information Exchange (HIE) using a custom, standards-compliant API build. We measured export speeds, data sizes, and completeness across 6 types of FHIR.

Results
Among the certified platforms, Oracle Cerner led in speed, managing 5-16 million resources at over 8000 resources/min. Three Epic sites exported a FHIR data subset, achieving 1-12 million resources at 1555-2500 resources/min. Notably, the HIE’s custom API outperformed, generating over 141 million resources at 12 000 resources/min.

Discussion
The HIE’s custom API showcased superior performance, endorsing the effectiveness of SMART/HL7 Bulk FHIR in enabling large-scale data exchange while underlining the need for optimization in existing EHR platforms. Agility and scalability are essential for diverse health, research, and public health use cases.

Conclusion
To fully realize the interoperability goals of the 21st Century Cures Act, addressing the performance limitations of Bulk FHIR API is critical. It would be beneficial to include performance metrics in both certification and reporting processes.
In-depth human immune cellular profiling from newborn to frail
Authors: Li Wangchun , Liu Hangyu , Gao Lijuan , Hu Yang , Zhang Anna , Li Wenfeng , Liu Guolong , Bai Weibin , Xu Yudai , Xiao Chanchan , Deng Jieping , Lei Wen , Chen Guobing 
Published: March 2024

Abstract
Immune functional decline and remodeling accompany aging and frailty. It is still largely unknown how changes in the immune cellular composition differentiate healthy individuals from those who become frail at a relatively early age. Our aim in this exploratory study was to investigate immunological changes from newborn to frailty and the association between health statute and various immune cell subtypes. The participants analyzed in this study covered human cord blood cells and peripheral blood cells collected from young adults and healthy and frail old individuals. A total of 30 immune cell subsets were performed by flow cytometry based on the surface markers of immune cells. Furthermore, frailty was investigated for its relations with various leukocyte subpopulations. Frail individuals exhibited a higher CD4/CD8 ratio; a higher proportion of CD4+ central memory T cells, CD8+ effector memory T cells, CD27− switched memory B (BSM) cells, CD27+ BSM cells, age-associated B cells, and CD38−CD24− B cells; and a lower proportion of naïve CD8+ T cells and progenitor B cells. The frailty index score was found to be associated with naïve T cells, CD4/CD8 ratio, age-associated B cells, CD27− BSM cells, and CD4+ central memory T cells. Our findings conducted a relatively comprehensive and extensive atlas of age- and frailty-related changes in peripheral leukocyte subpopulations from newborn to frailty. The immune phenotypes identified in this study can contribute to a deeper understanding of immunosenescence in frailty and may provide a rationale for future interventions and diagnosis.
Health-related quality of life and DNA methylation-based aging biomarkers among survivors of childhood cancer
Authors: Plonski Noel-Marie , Pan Yue , Chen Cheng , Dong Qian , Zhang Xijun , Song Nan , Shelton Kyla , Easton John , Mulder Heather , Zhang Jinghui , Neale Geoffrey , Walker Emily , Wang Hui , Webster Rachel , Brinkman Tara , Krull Kevin R , Armstrong Gregory T , Ness Kirsten K , Hudson Melissa M , Li Qian , Huang I-Chan , Wang Zhaoming 
Published: March 2024

Abstract

Background
Childhood cancer survivors are at high risk for morbidity and mortality and poor patient-reported outcomes, typically health-related quality of life (HRQOL). However, associations between DNA methylation–based aging biomarkers and HRQOL have not been evaluated.

Methods
DNA methylation was generated with Infinium EPIC BeadChip on blood-derived DNA (median for age at blood draw = 34.5 years, range = 18.5-66.6 years), and HRQOL was assessed with age at survey (mean = 32.3 years, range = 18.4-64.5 years) from 2206 survivors in the St Jude Lifetime Cohort. DNA methylation–based aging biomarkers, including epigenetic age using multiple clocks (eg, GrimAge) and others (eg, DNAmB2M: beta-2-microglobulin; DNAmADM: adrenomedullin), were derived from the DNAm Age Calculator (https://dnamage.genetics.ucla.edu). HRQOL was assessed using the Medical Outcomes Study 36-Item Short-Form Health Survey to capture 8 domains and physical and mental component summaries. General linear models evaluated associations between HRQOL and epigenetic age acceleration (EAA; eg, EAA_GrimAge) or other age-adjusted DNA methylation–based biomarkers (eg, ageadj_DNAmB2M) after adjusting for age at blood draw, sex, cancer treatments, and DNA methylation–based surrogate for smoking pack-years. All P values were 2-sided.

Results
Worse HRQOL was associated with greater EAA_GrimAge (physical component summaries: β = -0.18 years, 95% confidence interval [CI] = -0.251 to -0.11 years; P = 1.85 × 10−5; and 4 individual HRQOL domains), followed by ageadj_DNAmB2M (physical component summaries: β = -0.08 years, 95% CI = -0.124 to -0.037 years; P = .003; and 3 individual HRQOL domains) and ageadj_DNAmADM (physical component summaries: β = -0.082 years, 95% CI = -0.125 to -0.039 years; P = .002; and 2 HRQOL domains). EAA_Hannum (Hannum clock) was not associated with any HRQOL.

Conclusions
Overall and domain-specific measures of HRQOL are associated with DNA methylation measures of biological aging. Future longitudinal studies should test biological aging as a potential mechanism underlying the association between poor HRQOL and increased risk of clinically assessed adverse health outcomes.
Opioid use in cancer patients compared with noncancer pain patients in a veteran population
Authors: Mudumbai Seshadri C , He Han , Chen Ji-Qing , Kapoor Aditi , Regala Samantha , Mariano Edward R , Stafford Randall S , Abnet Christian C , Pfeiffer Ruth M , Freedman Neal D , Etemadi Arash 
Published: March 2024

Abstract

Background
Opioid safety initiatives may secondarily impact opioid prescribing and pain outcomes for cancer care.

Methods
We reviewed electronic health record data at a tertiary Veterans Affairs system (VA Palo Alto) for all patients from 2015 to 2021. We collected outpatient Schedule II opioid prescriptions data and calculated morphine milligram equivalents (MMEs) using Centers for Disease Control and Prevention conversion formulas. To determine the clinical impact of changes in opioid prescription, we used the highest level of pain reported by each patient on the 0-to-10 Numeric Rating Scale in each year, categorized into mild (0-3), moderate (4-6), and severe (7 and above).

Results
Among 89 569 patients, 9073 had a cancer diagnosis. Cancer patients were almost twice as likely to have an opioid prescription compared with noncancer patients (69.0% vs 36.7%, respectively). The proportion of patients who received an opioid prescription decreased from 27.1% to 18.1% (trend P &lt; .01) in cancer patients and from 17.0% to 10.2% in noncancer patients (trend P &lt; .01). Cancer and noncancer patients had similar declines of MMEs per year between 2015 and 2019, but the decline was more rapid for cancer patients (1462.5 to 946.4, 35.3%) compared with noncancer patients (1315.6 to 927.7, 29.5%) from 2019 to 2021. During the study period, the proportion of noncancer patients who experienced severe pain was almost unchanged, whereas it increased among cancer patients, reaching a significantly higher rate than among noncancer patients in 2021 (31.9% vs 27.4%, P &lt; .01).

Conclusions
Our findings suggest potential unintended consequences for cancer care because of efforts to manage opioid-related risks.
Diffuse hemispheric glioma with H3 p.K28M (K27M) mutation: Unusual non-midline presentation of diffuse midline glioma, H3 K27M-altered?
Authors: Donev Kliment , Sundararajan Vanitha , Johnson Derek , Balan Jagadheshwar , Chambers Meagan , Paulson Vera A , Scherpelz Kathryn P , Abdullaev Zied , Quezado Martha , Cimino Patrick J , Pratt Drew , Valerio Ediel , Alves de Castro João Vıctor , Carraro Dirce Maria , Torrezan Giovana Tardin , Wolff Beatriz Martins , Kulikowski Leslie Domenici , Costa Felipe D’Almeida , Aldape Kenneth , Ida Cristiane M 
Published: March 2024

Abstract
Diffuse midline glioma, H3 K27-altered (DMG-H3 K27) is an aggressive group of diffuse gliomas that predominantly occurs in pediatric patients, involves midline structures, and displays loss of H3 p.K28me3 (K27me3) expression by immunohistochemistry and characteristic genetic/epigenetic profile. Rare examples of a diffuse glioma with an H3 p.K28M (K27M) mutation and without involvement of the midline structures, so-called “diffuse hemispheric glioma with H3 p.K28M (K27M) mutation” (DHG-H3 K27), have been reported. Herein, we describe 2 additional cases of radiologically confirmed DHG-H3 K27 and summarize previously reported cases. We performed histological, immunohistochemical, molecular, and DNA methylation analysis and provided clinical follow-up in both cases. Overall, DHG-H3 K27 is an unusual group of diffuse gliomas that shows similar clinical, histopathological, genomic, and epigenetic features to DMG-H3 K27 as well as enrichment for activating alterations in MAPK pathway genes. These findings suggest that DHG-H3 K27 is closely related to DMG-H3 K27 and may represent an unusual presentation of DMG-H3 K27 without apparent midline involvement and with frequent MAPK pathway activation. Detailed reports of additional cases with clinical follow-up will be important to expand our understanding of this unusual group of diffuse gliomas and to better define the clinical outcome and how to classify DHG-H3 K27.
Evolutionary pathways of complexity in gender systems
Authors: Shcherbakova Olena , Allassonnière-Tang Marc 
Published: March 2024

Abstract
Humans categorize the experience they encounter in various ways, which is mirrored, for instance, in grammatical gender systems of languages. In such systems, nouns are grouped based on whether they refer to masculine/feminine beings, (non-)humans, (in)animate entities, or objects with specific shapes. Languages differ greatly in how many gender assignment rules are incorporated in gender systems and how many word classes carry gender marking (gender agreement patterns). It has been suggested that these two dimensions are positively associated as numerous assignment rules are better sustained by numerous agreement patterns. We test this claim by analyzing the correlated evolution (Continuous method in BayesTraits) and making the causal inferences about the relationships (phylogenetic path analysis) between these 2 dimensions in 482 languages from the global Grambank database. By applying these methods to linguistic data matched to phylogenetic trees (a world tree and individual families), we evaluate whether various types of gender assignment rules (semantic, phonological, and unpredictable) are causally linked to more gender agreement patterns on the global level and in individual language families. Our results on the world language tree suggest that semantic rules are weakly positively correlated with gender agreement and that the development of agreement patterns is facilitated by different rules in individual families. For example, in Indo-European languages, more agreement patterns are caused by the presence of phonological and unpredictable rules, while in Bantu languages, the driving force of agreement patterns is the variety of semantic rules. Our study shows that the relationships between agreement and rules are family-specific and yields support to the idea that more distinct rules and/or rule types might be more robust in languages with more pervasive gender agreement.