bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beneficial effect of synbiotic combination of Limosilactobacillus fermentum FS-10, Lactiplantibacillus plantarum Lp1-IC and short-chain Fructooligosaccharides in colitis murine model
Authors: Pujari Radha , Jadhav Deepak , Angal Ashvini , Syed Jaserah , Dubey Ashok Kumar 
Published: March 2024

Abstract
Therapies targeting gut-microbiota are being extensively researched for colitis patients. In this study, we have tested the efficacy of indigenously isolated strains Lactiplantibacillus plantarum Lp1-IC and Limosilactobacillus fermentum FS-10 and their combination with short chain fructooligosaccharides (sc-FOS) in mice models of DSS-induced colitis. For a desired efficacy, a synbiotic should be very meticulously formulated with the right choice of prebiotic and probiotic. Therefore, the ability of Lactobacilli to selectively utilize scFOS for growth was first tested by culturing the strains in a specially designed minimal media supplemented with scFOS as carbon source. The bacteria utilized scFOS and produced metabolites such as acetate and lactate. Thereafter, the in vitro anti-inflammatory effect was tested on markers such as TNF-alpha (TNF-α), Nitric Oxide and IL-10 in human monocyte (THP-1) and mouse macrophage (Raw 264-7) cell lines. The in vivo efficacy was studied in mice model of DSS-induced colitis and the effect on the systemic and localized inflammatory markers were assessed in serum and colon tissues samples respectively. Administration of DSS elicited predominant clinical signs of weight loss, diarrhoea, fecal occult blood, increase in inflammatory markers and extensive damage of colon tissue. These symptoms were significantly reversed in all the treatment groups, however the combination of lactobacilli and scFOS performed better than the individual ingredients. The study highlights the potential of the indigenous lactobacilli strains, scFOS and their combination for management of gut-inflammation in colitis patients.
Emergency department use in the postpartum period: a retrospective cohort study
Authors: Reische Elijah , Santillan Mark , Cunningham Victoria , Blocklinger Kelsey , Hunter Stephen , Faro Elissa , Davis Heather , Knosp Boyd , Santillan Donna 
Published: March 2024

Abstract
Background:
Visits to the emergency room (ED) by women in the postpartum period may reflect gaps in postpartum care and disparities in access to obstetric and primary care services. This study aimed to characterize the patients who visited the ED in the first year after delivery, their reasons for coming to the ED, and the care they received.
Methods:
The electronic health record was reviewed for all patients who delivered at University of Iowa Health Care between 2009 and 2023 and visited the ED within 365 days after delivery. Data drawn directly from the EHR included patient demographics and medical history, pregnancy and delivery information, and newborn characteristics. The charts were then reviewed manually for information regarding ED visits including time from delivery, chief complaint, diagnosis, and disposition.
Results:
555 pregnancies had ED visits within one year of delivery, with a total 814 ED visits across the study sample. 46.7% of ED visits occurred in the first 30 days following delivery, and 35% of ED visits for obstetric complaints occurred in the first 2 weeks after delivery. Black patients visited the ED more often (mean=1.84 visits, SD=1.30) than white (mean=1.34, SD=0.92, p<0.001) or Hispanic patients (mean=1.35, SD=0.67, p = 0.004). The most common categories of chief complaint were obstetric (34.6%) and gastrointestinal (18.8%), while the most common categories of diagnosis were obstetric (31.8%) and immune/infectious (28.1%).
Conclusions:
Visits to the ED are common in the year following delivery. Almost half of these visits occur in the first 30 days after birth. The plurality of postpartum ED visits are due to obstetric complaints, especially in the first few weeks. Black women are more likely to use the ED during this period, potentially due to disparities in healthcare access. These findings suggest that some of these ED visits may be preventable, and that there is room for improvement in post-delivery follow-up, communication between patients and the obstetrics team, and access to outpatient obstetric care.
The importance of Evaluation of microorganisms in raw sewage sludge intended for agriculture
Authors: BOUCHAALA Laid , GRARA Nedjoud , CHARCHAR Nabil , NOURINE Heidar , DAHDAH Kamal , DRIOUCHE Youssouf , Atoki Ayomide Victor 
Published: March 2024

Abstract
The present study was conducted to determine the microbiological characteristics of sewage sludge from five waste-water treatment plants (WWTPs) in eastern Algeria and to assess the efficiency of drying beds in lowering the microbial load in this sludge, which is typically used in agricultural fields. We chose the five most significant waste-water treatment facilities in Algeria's Eastern area to carry out this study. Where we have counted harmful microorganisms (Salmonella, Clostridium), and examined parasites. Total coliforms, fecal "E. coli" and fecal streptococci were used as indicators of fecal contamination. The obtained results indicate that the examined sewage sludge is a rich source of microorganisms, particularly bacteria of fecal origin, especially during the months of high temperature (Spring, Summer), and moor particular in the sludge of medium age (more than 1 month). As a result, we have reported a significant presence of anaerobic sulfate-reducingria (ASR), Salmonella spp., and E. coli. We also observed that this sludge included parasites, ranging from protozoa to helminth eggs. We may draw the conclusion that even if the microbiological load in the sewage sludge significantly decreased after treatment in the drying beds, the hazards associated with the spread of this sludge must be managed by adherence to a set of exact guidelines. This study allowed us to determine the microbiological properties of sewage sludge, through which we can reduce the risks or definitively eliminated, which allows the possibility of valued them in the agricultural sector by avoiding all possible environmental risks and even on health public.
Exploring perspectives of type 2 diabetes prevention program coaches and training delivery staff on coach e-learning training: A qualitative study
Authors: Cranston Kaela D , Grieve Natalie J , Jung Mary E 
Published: March 2024

Abstract

Background
E-learning can be an effective and efficient mode of training healthcare practitioners. E-learning training for diabetes prevention program coaches was designed and developed with input from end users. Insight from those who deliver the training and coaches who have taken the training can provide critical feedback for further refinement of the e-learning training. The purpose of this study was to understand diabetes prevention coaches’ and training delivery staffs’ perspectives of the coach e-learning training.
Methods
A pragmatic paradigm guided the methodology for this study. Semi-structured interviews were conducted with diabetes prevention program coaches (n = 8) and diabetes prevention program training staff (n = 3). Interviews were recorded, transcribed verbatim, and analyzed using template analysis. Themes and subthemes were separately constructed from coach and staff data.
Results
There were seven themes constructed from the coach data: training design, “I didn’t know what to expect from the training”, technology usability, learning, coaches’ backgrounds shaped their training experience, support, and coaches valued the training. Two themes were constructed from the staff interviews: streamlining the training delivery, and ensuring coaches meet the diabetes prevention program standard.
Conclusions
This study highlights the importance of exploring perspectives of both those going through and delivering e-learning training to refine content and processes. Qualitatively evaluating the implementation of e-learning training will lead to a more acceptable, efficient, and effective e-learning training. Coaches and staff emphasized the benefits of having high-quality online components, that the brief training promoted gains in knowledge and improvements in skills, and that e-learning training refinements will lead to further satisfaction and effectiveness. Results can be used to inform modifications to the coach e-learning training for this diabetes prevention program and to inform other healthcare practitioner e-learning trainings.
Valuating the efficiency of social security and healthcare in OECD countries from a sustainable development
Authors: Lee Li-wen , Chiu Yung-ho , Liu Fan-peng , Lin Tai-Yu , Chang Tzu-Han 
Published: March 2024

Abstract
As the global population ages, the average health expenditures among OECD countries rose from 7.8% of GDP in 2005 to 9.9% in 2020, while social security and welfare expenditures increased from 14.5% of GDP in 1980 to 20.2% in 2016. However, social security and healthcare are related to SDG1, SDG3, and SDG10. Looking over the data envelopment analysis (DEA) literature, it is rare to distinguish functional differences when evaluating social security efficiency, which is mostly mixed between social insurance and healthcare, and the impact of social security on healthcare efficiency has not yet been any major focus. This research uses the two-stage recycle dynamic undesirable SBM DEA model to observe the efficiency of social security and healthcare in OECD countries. Thereare three findings as follows. First, we find that the higher is social security efficiency, the better is healthcare efficiency of countries with GDP per capita below US$41,500. Second, the higher is social security efficiency of National Health Service (NHS) countries, the better is healthcare efficiency. When the financial source of the social security system is taxation, then it is more likely to bring higher efficiency to healthcare.
Comprehensive bibliometric and visualized analysis of research on front crawl biomechanics published from 1984 to 2023
Authors: HUANG Dongxiang , ZHANG Keyi , CHOW Huang Kay 
Published: March 2024

Abstract
Background
The biomechanical review of front crawl (FC) swimming can enhance athletes' technical proficiency and prevent sports injuries. Over the last 39 years, considerable research has been conducted on FC biomechanics. However, there exists a need for more bibliometrics studies. The objective of this study is to create a knowledge map highlighting the prominent research areas and cutting-edge frontiers in the field of FC biomechanics.
Methods
Using Citespace, this study conducts bibliometric and visualization analysis of 508 articles in the field of FC biomechanics sourced from the Web of Science Core Collection database. The study focuses on collaboration networks among authors. Additionally, it examines the co-citation analysis of journals and performs co-occurrence, cluster, and burst term analysis on keywords.
Results
Ricardo J. Fernandes is the most influential author. We found that the journal INT J SPORTS MED has been the most frequently cited publication. The popular keywords in this field include velocity, performance, and swimmers. Moreover, we identified several burst keywords, such as body roll, stroking characteristics, and motor control. Through cluster analysis, we identified that body roll, drag, motor control, and training are highly interconnected concepts in this domain.
Conclusion
The forefront of research in the field of FC biomechanics has evolved from a focus on fundamental techniques to addressing complex problems and, subsequently, validating research methods and data reliability. Future research directions may consider separately analyzing the impact of shoulder and hip rotation on freestyle performance, investigating the effects of training on freestyle starts or turns, and exploring the potential and application scope of inertial sensors. By integrating other technologies and methods, this research aims to provide comprehensive support and guidance for the training and performance of swimmers.
Fast Reactions and Slow Manifolds
Authors: Kuehn Christian , Sulzbach Jan-Eric 
Published: March 2024

Abstract
In this paper we generalize the Fenichel theory for attracting critical/slow manifolds to fast-reaction systems in infinite dimensions. In particular, we generalize the theory of invariant manifolds for fast-slow partial differential equations in standard form to the case of fast reaction terms. We show that the solution of the fast-reaction system can be approximated by the corresponding slow flow of the limit system. Introducing an additional parameter that stems from a splitting in the slow variable space, we construct a family of slow manifolds and we prove that the slow manifolds are close to the critical manifold. Moreover, the semi-flow on the slow manifold converges to the semi-flow on the critical manifold. Finally, we apply these results to an example and show that the underlying assumptions can be verified in a straightforward way.
Mathematics Subject Classification (2010). 35B25, 35A24, 37D10, 37L25.
Unilateral biportal endoscopic lumbar interbody fusion (ULIF) versus minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) for the treatment of degenerative lumbar spondylolisthesis: a retrospective analysis
Authors: Zhu Zhicheng , He Banglin , Sun Jifu , Lin Liqun , Meng Chen , Sun Yan , Jiang Chao , Huang Yonghui 
Published: March 2024

Abstract
Objective: This study retrospectively compared the early clinical and imaging outcomes of the single-level Meyerding Grade Ⅰ degenerative lumbar spondylolisthesis (DLS) between unilateral biportal endoscopic lumbar interbody fusion (ULIF) and minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) using an expandable tubular retractor system under a surgical loupe.
Methods: This was a retrospective study. This study included fifty-five patients (twenty-eight patients underwent ULIF and twenty-seven patients who underwent MI-TLIF at the Affiliated Hospital of Jiangsu University from June 2020 to July 2021. Demographic characteristic, surgical parameters, laboratory results, and clinical and imaging outcomes were collected and compared between the two groups.
Results: The mean estimated blood loss was significantly lower in the ULIF group (P<0.001). However, the mean operative time was significantly longer than in the ULIF group than in the MI-TLIF group (P<0.05). The mean CK and CRP levels on the first postoperative day were significantly lower in the ULIF group (P<0.001). All clinical scores improved significantly after the operation in both groups. The VAS back score for pain at two weeks and 1 month postoperatively was significantly lower in the ULIF group (P<0.05). There was no significant difference between the two groups in the change in the dural sac cross-sectional area preoperatively or at the final postoperative follow-up. The fusion rate was significantly greater in ULIF at 6 months after the operation (P<0.05).
Conclusion: Compared to MI-TLIF, the ULIF technique has the advantages of less hemorrhage, less inflammation, and earlier fusion. However, this approach has a limited operation time. However, further clinical outcomes need to be followed up in the longer term.
Identification and Multi-omic Analysis of Essential Coding and Long Non-conding Genes in Colorectal Cancer
Authors: Li Yanguo , Han Tianci , Fan Chengjiang , Rong Hao , Wang Huifang , Yu Chen , Xi Yang , Liao Qi 
Published: March 2024

Abstract
Essential genes are indispensable for the survival of cancer cell. CRISPR/Cas9-based pooled genetic screens have distinguished the pan-cancer essential genes and their functions in distinct cellular processes. Nevertheless, the landscape of essential genes at the single cell levels and the effect on the tumor microenvironment (TME) via cell-to-cell communication network (CCN) remains limited. Here, we identified 396 essential protein-coding genes (ESPs) by integration of 8 genome-wide CRISPR loss-of-function screen datasets of colorectal cancer (CRC) cell lines and a full-length single cells transcriptome data of CRC tissues. Then, 29 essential long non-coding genes (ESLs) were predicted using Hypergeometric Test (HT) and Personalized PageRank (PPR) algorithms based on ESPs and co-expressed network constructed from single cell transcriptome data. CRISPR/Cas9 knockout experiment verified the effect of several ESPs and ESLs on the survival of CRC cell line. Furthermore, multiple omics features of ESPs and ESLs were illustrated by examining their expression patterns and transcription factor (TF) regulatory network at the single cell level, as well as DNA mutation and DNA methylation events at bulk level. Finally, through integrating multiple intracellular regulatory networks with CCN, we elucidated that CD47 and MIF are regulated by multiple CRC essential genes and the anti-cancer drugs sunitinib can interfere the expression of them potentially. Our findings provide a comprehensive asset of CRC ESPs and ESLs, sheding light on the mining of potential therapy targets for CRC.
Design of a floating-point adder/subtractor based on reversible circuits
Authors: Dong Bolin , Sun Ao , Huang Feixiang , Chang Weijie 
Published: March 2024

Abstract
Reversible circuits are a possible alternative to conventional circuits because they have the same input and output and avoid power loss due to bit erasure operations. It has been widely used in various research areas such as optical computing, low-power CMOS design, DNA computing, quantum computing and thermodynamic techniques. In this paper, we suggest a novel design for a 16-bit floating-point reversible adder/subtractor that is complied with IEEE-754 standard. This design proposes the use of signal control bits to determine whether to add or subtract floating-point numbers, thereby increasing the operation speed. The key to reducing quantum cost, constant input, and garbage output lies in the design of reusable components. Finally, the feasibility of the design is verified by FPGA.
Psychological distress and health behaviours in people living with and beyond cancer: a cross-sectional study
Authors: Miller Natalie Ella , Lally Phillippa , Conway Rana , Steptoe Andrew , Frank Philipp , Beeken Rebecca J , Fisher Abi 
Published: March 2024

Abstract
Purpose
This study aimed to examine whether psychological distress was cross-sectionally associated with meeting World Cancer Research Fund (WCRF) recommendations in people living with and beyond cancer.
Methods
Participants were adults living with and beyond breast, prostate and colorectal cancer, participating in the baseline wave of the Advancing Survivorship after Cancer Outcomes Trial (ASCOT). Anxiety/depression was assessed using the EQ-5D-5L and dichotomised into any/no problems. WCRF recommendations were assessed via pedometers, 24-hour dietary recalls, self-reported alcohol intake (AUDIT-C), and self-reported smoking status. A composite health behaviour risk index (CHBRI) was calculated by summing the number of WCRF recommendations met (range: 0-9).
Results
Among 1348 participants (mean age = 64 years (SD = 11.4)), 41.5% reported anxiety/depression problems. The mean CHBRI score was 4.4 (SD = 1.4). Anxiety/depression problems were associated with a lower CHBRI score, after multivariable adjustment (beta = -0.27; 95% confidence interval (CI): -0.46, -0.07). Anxiety/depression problems were also associated with lower odds of meeting WCRF recommendations for average daily steps (odds ratio (OR) = 0.73; 95% CI: 0.55, 0.97) and average weekly aerobic steps (OR = 0.78; 95% CI: 0.67, 0.92), but not for any other health behaviour.
Conclusions
Psychological distress is associated with lower adherence to WCRF recommendations in people living with and beyond cancer, and specifically with not meeting physical activity recommendations.
Implications for cancer survivors
Physical activity may be a mechanism linking psychological distress and poorer outcomes among people living with and beyond cancer, and this should be explored in longitudinal studies.
Development and Validation of UV Spectrophotometric Method for Determination of Tepotinib in Bulk and Pharmaceutical Dosage Forms
Authors: Kumar Meruva Sathish , Mrs.S.Marakatham  , Polampalli Phani Deepika , Prasad S.Siva 
Published: March 2024

Abstract
The aim of this study was to develop a new, rapid and highly sensitive UV spectrophometer method for the Tepotinib bulk drug. The mobile phase consisted of Water & Acetonitrile in the ration of 50:50v/v and the wavelength to maximum absorbance at 256.0 nm. Analytical calibration curves were linear within a concentration range from 2.5 to 15µg/ml and coefficient of correlation 0.999. %RSD was found to be less than 2. The result of analysis has been validated statistically. This method will be validated in accordance with ICH requirements included the linearity, precision, accuracy sensitivity, and specificity. Hence the proposed method can be used for the reliable quantification of Tepotinib in tablet formulation.
Design and Analysis Aerospike Blunt Body at Hypersonic Speed
Authors: MUZEER.S  , RR Vinoth Kumar 
Published: March 2024

Abstract
Hypersonic vehicles have the drag and heating problem when they operate at high speeds, to avoid or minimize this problem, aero spikes are utilized. This investigation finds a solution for reducing the drag and heating. Using ANSYS fluent, designed an aero spike, which has flow around a blunt body at highpersonic Mach number 6 with angle of attack zero. It is analyses for L/D ratio of 1.5 and 2. The front of the body is replaced by an aero spike which has weak oblique shocks and well-built detached shock. This develops a circular region between shock and blunt body. This works as a streamlined profile to reduce heat as well as drag.
First-year accounting students' experiences adjusting chalenges to university life
Authors: Mokhampanyane Matsolo 
Published: March 2024

The object of research: to explores the adjustment experiences to university life of first year accounting students.
Investigated problems: Adaptation challenges, to the university environment which creates significant stress, affect retention, academic performance, and social demands of first year students – all academic and social integrations are major challenges for first year students.
The main scientific results: The findings for the study revealed that first-year accounting students report encouraging and undesirable academic and social adjustment experiences respectively. Encouraging academic adjustment experiences related to the availability of support from departmental personnel from the faculty. Undesirable academic experiences included lack of time management, and workload and independence issues.
The area of practical use of the research results: Encouraging social adjustment included, among others, the introduction of mentors to first years, as well as a wellness center; on the other hand, undesirable social adjustment highlighted independence and disintegration. The study further suggests that universities, through their student support services and faculties, should have in place support strategies, as well as a programme, which promote the interaction of first year students within their institutions throughout their first year of study.
Innovative technological product: According to the findings, the study recommends coordinated methods to ensure that the first year's accountings receive full support in order to help them successfully adapt to and fit into the new environment. The introduction of electronic platforms that allow first-year stakeholders to organize students and interact with their lecturers and other support structures like mentors and supplemental instructors (SI) a few weeks before the official class sessions is promoted. Additionally, it might be recommended for the wellness center to host workshops for freshmen on time management, managing the workload at the institution, and how independence can occasionally work against a student's academic wellbeing.
Scope of the innovative technological product: Students in their first year of accounting at one of South Africa's technical universities served as the study's respondents.