bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of a Business Incubator on the Business Success of a Beginner Entrepreneur: Case Study of a Technology-innovation Center in Međimurje County
Authors: Rončević Ante , Ličanin Aleksandra 
Published: February 2024

Abstract
The recession of the 1990s in Europe and the United States of America marked a defining moment for entrepreneurship. Business incubators emerged as a means of redistributing strategic resources and developing new tools for local and regional economies. In Croatia, most incubators are founded by cities and counties, with two private incubators also in operation. The Technological Innovation Center “Međimurje” (TICM) in Čakovec was established by Međimurje County in 2009 to incubate startup entrepreneurs, with the aim of supporting regional development and strengthening the entrepreneurial sector. With recent population emigration, the Međimurje County Development Plan until 2027 underscores the heightened importance of TICM as an entrepreneurial support institution. This paper presents a comprehensive analysis of the challenges, needs, and obstacles faced by beginner entrepreneurs working in the TICM incubator. It critically evaluates the extent to which TICM meets the needs of newly founded companies, identifies the challenges it faces, and proposes solutions. By analysing the survey responses, the research questions were answered, and guidelines for the potential future operation of the incubator were developed. Research shows unequivocally that there are numerous advantages of doing business in an incubator, primarily the possibility of survival in the market. The work determines the needs of beginner entrepreneurs, which can guide the building and redefinition of existing services, and also highlights the need to increase the incubator’s capacity.
Simultaneous determination of sulfonamides, trimethoprim, amoxicillin and tylosin in medicated feed by high performance liquid chromatography with mass spectrometry
Authors: Patyra Ewelina , Kwiatek Krzysztof 
Published: February 2024

Abstract

Introduction
The article presents a rapid and simple analytical procedure for determination of four sulfonamides (sulfadiazine, sulfamerazine, sulfamethazine and sulfamethoxazole), trimethoprim, tylosin and amoxicillin in animal medicated feed.

Material and Methods
Eighteen medicated feed samples were analysed for active substances. The analytical protocol used a mixture of acetonitrile and 0.05 M phosphoric buffer, pH 4.5 for the extraction of seven antibacterial substances. After extraction, the samples were diluted in Milli-Q water and analysed by liquid chromatography with mass spectrometry. The developed procedure was subjected to validation in terms of linearity, selectivity, limits of quantification and determination, repeatability, reproducibility and uncertainty.

Results
The validation of the method was carried out in accordance with the criteria set out in Commission Implementing Regulation (EU) 2021/808 and ICH guidelines. This method provided average recoveries of 90.8 to 104.5% with coefficients of variation for repeatability and reproducibility in the ranges of 3.2–6.9% and 5.2–8.3%, respectively for all analysed antibacterial substances. The limit of detection and limit of quantification for all seven analytes ranged from 5.4 mg/kg to 48.3 mg/kg and from 10.4 mg/kg to 119.3 mg/kg, respectively. The uncertainty of the method depending on the compound varied from 14.0% to 24.0%. The validated method was successfully applied to the 18 medicated feeds.

Conclusion
The developed method can be successfully used to routinely control the content and homogeneity of seven antibacterial substances in medicated feed.
Social Capital and Entrepreneurial Performance of SMEs: The Mediating Role of Access to Entrepreneurial Resources
Authors: Ghi Tran Nha , Trung Nguyen Tan , Long Nguyen Thanh , Dat Nguyen Hoang Anh 
Published: February 2024

Abstract
This study is conducted to explain entrepreneurial support resources of firms based on social network theory in developing countries, the case of Vietnam. Partial Least Squares Structural Modeling (PLS-SEM) was conducted with a sample size of 220 entrepreneurs in SMEs. The results supported the positive link between formal and informal networks and entrepreneurial firm performance. Second, the study explored the partial mediating role of access to entrepreneurial resources between formal networks, informal networks, and entrepreneurial firm performance. In addition, the results also provide practical value to entrepreneurs in actively building relationship networking in the entrepreneurship ecosystem. Finally, the study proposed some implications for entrepreneurs, limitations, and further research.
The Future of Automotive Quality Control: How Cloud-Based Reporting is Changing the Game
Authors: Cieśla Jakub , Ulewicz Robert 
Published: February 2024

Abstract
The automotive industry faces challenges in maintaining quality control while at the same time reducing costs and improving efficiency. Outsourcing has emerged as a potential solution. Such an approach can create issues such as communication barriers, quality control problems, and limited visibility into the manufacturing process. This study proposes a cloud-based quality reporting solution to overcome these challenges by providing real-time data analytics, facilitating proper communication, and enabling visibility into quality control processes. This solution significantly reduces waiting times for information regarding product quality status and allows interested parties to access data immediately. The outsourcing company, product producer and customer receive flexible, traceable, mobile cloud-based analytics in real-time. Challenges of this solution are the need to secure data, manage access and ensure the appropriate quality of data by persons performing control. The paper provides practical recommendations for implementing cloud-based quality reporting systems.
ESTRATÉGIAS DE IRRIGAÇÃO COM ÁGUA SALOBRA E ADUBAÇÃO NA CULTURA DO AMENDOIM
Authors: Matos da Cruz Filho Elizeu , Gomes de Sousa Geocleber , Rocha Ribeiro Rute Maria , Chiumbua Cambissa Paulo Bumba , Pires de Souza Maria Vanessa , Da Silva Nogueira Rafaella 
Published: February 2024

O uso de água salobra associada ao manejo inadequado da adubação afeta a produtividade das culturas agrícolas. Objetivou-se com a pesquisa avaliar a produtividade da cultura do amendoim submetida a diferentes estratégias de irrigação com água salobra e adubação mineral e organomineral. O delineamento utilizado foi inteiramente casualizado, em esquema fatorial 5 x 2, com quatro repetições, sendo utilizadas cinco estratégias de irrigação com água salobra com condutividade elétrica de 4,0 dS m-1: EI1= água salobra a partir dos 7 dias após a semeadura – DAS; EI2= água salobra a partir dos 15 DAS; EI3= água salobra a partir dos 25 DAS; EI4= água salobra a partir dos 35 DAS e EI5= tratamento controle - sem estresse salino) com duas adubações (M= mineral, OM= organomineral). A adubação organomineral atenuou o efeito negativo do estresse salino no tratamento com início da irrigação com água salobra aos 15 e 25 dias após a semeadura para o diâmetro da vagem, 35 DAS para a massa de vagem e aos 25 e 35 para a produtividade. A estratégia de uso de água salobra aos sete dias após a semeadura afeta o desempenho da cultura em comprimento da vagem e aos 7,15, 25 e 35 o número de vagem por planta.
Palavras-chave: Arachis hypogaea L.; biofertilizante; estresse salino; nutrição de plantas.

Irrigation strategies with bracky water and fertilization in peanut crops

ABSTRACT: The use of brackish water associated with inadequate fertilizer management affects the productivity of agricultural crops. The research objective was to evaluate the productivity of peanut crops subjected to different irrigation strategies with brackish water and mineral and organomineral fertilization. The design used was completely randomized, in a 5 x 2 factorial scheme, with four replications, using five irrigation strategies with brackish water with an electrical conductivity of 4.0 dS m-1: EI1= brackish water from 7 days after irrigation. sowing – DAS; EI2= brackish water from 15 DAS; EI3= brackish water from 25 DAS; EI4= brackish water from 35 DAS and EI5= control treatment - without saline stress) with two fertilizers (M= mineral, OM= organomineral). Organomineral fertilization attenuated the negative effect of saline stress in the treatment with the start of irrigation with brackish water at 15 and 25 days after sowing for pod diameter, 35 DAS for pod mass and at 25 and 35 for productivity. The strategy of using brackish water seven days after sowing affects crop performance in terms of pod length, and at 7,15, 25, and 35, the number of pods per plant.
Keywords: Arachis hypogaea L.; biofertilizer; salt stress; plant nutrition.
Біоетичні та медико-соціальні аспекти лікування дитини, хворої на гранулематоз з поліангіітом: клінічний випадок
Authors: Stoieva T.V. , Titkova O.V. , Fomina S.P. , Doikova K.M. , Prohorova S.V. , Aplevich V.M. 
Published: February 2024

Гранулематоз з поліангіїтом (ГПА) є найбільш частим з АНЦА-асоційованих васкулітів в педіатричній популяції. Перебіг захворювання, для якого характерний надвисокий рівень несприятливих клінічних наслідків, залежить не тільки від своєчасної діагностики і дотримання протоколу, а й взаємодії з пацієнтом та його близькими.
Мета роботи: висвітлення перебігу ГПА у дитини, обтяженого соціальними обставинами та опікун-залежними особливостями терапевтичного супроводу.
Клінічний випадок. Початок захворювання у 12-ти річного хлопчика характеризувало ураження верхніх дихальних шляхів (синусит), лікування якого за протоколом протягом 4-х місяців не сприяло ліквідації симптомів. Своєчасне виконане КТ з ознаками, характерними для ГПА, не було розглянуто з точки зору наявності рідкісної хвороби. Приєднання нових симптомів (знесилення, деформація спинки носу, геморагічна висипка, кровохаркання, тромбоз глибоких вен нижньої кінцівки) спонукало до поглибленого обстеження, яке виявило мультисистемність ураження (анемія важкого ступеня, множинні вогнища в легенях, протеїнурія нефротичного рівня, гематурія, порушенням азотовидільної функції нирок) та високий рівень IgG до протеїнази-3. Особливості презентація ГПА з поступовим залученням інших систем і наростанням симптоматики на фоні не готовності клініцистів до рідкісного діагнозу і відсутності мультидисциплінарного підходу відтермінували початок імуносупресивної терапії. Обтяжені соціальні обставини (не готовність родини до діагнозу та прийняття клінічного рішення) трагічно погіршили сценарій хвороби.
Висновки. Неоднозначні ситуації, які виникають у педіатричній практиці при лікуванні рідкісної хвороби, вимагають обговорення широкого кола етичних проблем при взаємодії лікаря та пацієнта і його родини. Включення в клінічні настанови (особливо при захворюваннях з несприятливим прогнозом) біоетичних, психо-соціальних та правових фрагментів по захисту та підтримці хворих на всіх етапах спостереження, мають стати обов’язковим доповненням до стандартного терапевтичного супроводу.
Enlarged tumefactive perivascular, or Virchow-Robin, spaces and hydrocephalus: do we need to treat? Illustrative cases
Authors: Neyazi Belal , Swiatek Vanessa Magdalena , Stein Klaus-Peter , Hartmann Karl , Rashidi Ali , Zubel Seraphine , Amini Amir , Sandalcioglu I. Erol 
Published: February 2024

BACKGROUND
Perivascular spaces (PVSs) are spaces in brain parenchyma filled with interstitial fluid surrounding small cerebral vessels. Massive enlargements of PVSs are referred to as “giant tumefactive perivascular spaces” (GTPVSs), which can be classified into three types depending on their localization. These lesions are rare, predominantly asymptomatic, and often initially misinterpreted as cystic tumor formations. However, there are several reported cases in which GTPVSs have induced neurological symptoms because of their size, mass effect, and location, ultimately leading to obstructive hydrocephalus necessitating neurosurgical intervention. Presented here are three diverse clinical presentations of GTPVS.

OBSERVATIONS
Here, the authors observed an asymptomatic case of type 1 GTPVS and two symptomatic cases of type 3 GTPVS, one causing local mass effect and the other hydrocephalus.

LESSONS
GTPVSs are mostly asymptomatic lesions. Patients without symptoms should be closely monitored, and biopsy is discouraged. Hydrocephalus resulting from GTPVS necessitates surgical intervention. In these cases, third ventriculostomy, shunt implantation, or direct cyst fenestration are surgical options. For patients presenting with symptoms from localized mass effect, a thorough evaluation for potential neurosurgical intervention is imperative. Follow-up in type 3 GTPVS is recommended, particularly in untreated cases. Given the infrequency of GTPVS, definitive guidelines for neurosurgical treatment and subsequent follow-up remain elusive.
Cerebral venous sinus thrombosis detected using diffusion-weighted magnetic resonance imaging during maintenance temozolomide chemotherapy in a patient with glioblastoma: illustrative case
Authors: Takeuchi Youhei , _ _ , Saito Ryuta , Kanamori Masayuki , Niizuma Kuniyasu , Mugikura Shunji , Endo Hidenori 
Published: February 2024

BACKGROUND
Cerebral venous sinus thrombosis (CVST) sometimes occurs in the background of hypercoagulopathic disorders, including malignancy, chemotherapy, etc. Glioblastoma (GBM) is a malignancy found in the central nervous system, and reports on cases of GBM complicated by CVST are sparse. The authors herein report a case of GBM complicated by CVST during maintenance temozolomide (TMZ) chemotherapy and describe the utility of diffusion-weighted magnetic resonance imaging (MRI) for the detection of CVST.

OBSERVATIONS
A 65-year-old male was treated for left temporal GBM. After surgical removal of the lesion, the patient was treated with chemoradiation therapy, which included 60 Gy local radiation with concomitant TMZ chemotherapy. He was subsequently received TMZ maintenance therapy. Routine MRI performed 7 months after surgery revealed no evidence of tumor recurrence. However, diffusion-weighted imaging (DWI) revealed a high-intensity signal at the posterior portion of the superior sagittal sinus, indicating the presence of a thrombus. In addition to the preexisting symptoms, the patient experienced some disorientation. Angiography revealed an obstruction in the superior sagittal sinus, right transverse sinus, right sigmoid sinus, and straight sinus. His symptoms improved with endovascular and anticoagulant therapy.

LESSONS
Performing DWI during routine follow-up can help in the early diagnosis of CVST in patients with malignant gliomas.
TANTANGAN MASYARAKAT DALAM PROSES PEMBELAJARAN ONLINE SELAMA COVID-19
Authors: Nuranisa Nuranisa , Putri Mega Kusuma , Utomo Budi , Rosita Laili , Hartono Deni Puji 
Published: February 2024

Penelitian ini bertujuanÂ untuk mengidentifikasi tantangan yang dirasakan oleh masyarakatÂ saat proses pembelajaran selama covid-19 denganÂ mengunakanÂ metode deskriptif kualitatif. InformanÂ dalam penelitian ini adalah masyarakat Kota Palembang dengan kriteria yang berhubungan dengan proses pembelajaran seperti orang tua, guru, mahasiswa dan pelajar tingkat SMP dan SMA.Â Data dikumpulkan dengan angket dan dokumentasi.Â Data AnalisisÂ menggunakan teknik kualitatif Miles dan Huberman yaitu: Data Reduction (Reduksi Data), Data Display, dan Conclusion Drawing/Verivication. Hasil dari penelitian ini yaitu tantangan terbesar yang dirasakan masyarakat selama pembelajaran daring adalah akses internet yang belum stabil, masyarakat masih terkendala untuk mengakses jaringan, Sinyal hilang saat listrik mati,Â pengetahuan orang tua masih kurang dalam mengoperasikan perangkat elektronik. Ketersediaan alat yang memadai dengan kurangnya kemampuan mengoperasikan perangkat dan akses jaringan yang tidak stabil membuat proses pembelajaran online tidak dapat dilaksakana secara maksimal.
Тарбағатай топонимдеріндегі атаулар семантикасы
Authors: Мамышева М.Е. , Сейітова Ш.Б. 
Published: February 2024

Мақалада Шығыс Қазақстан облысына қарасты Тарбағатай ауданында кездесетін тарихи топонимдер қарастырылады. Қазақ топонимдік фольклор үлгілерінің ішінде Тарбағатай өңіріне қатысты аңыз-әпсаналар зерттеу нысанына алынып, олардағы жер атауларының мән-мағынасы, тарихи-танымдық бастаулары талданады. ХҮІІІ–ХІХ ғасырларда жазылған саяхатшылар еңбектеріндегі жер-су атауларына қатысты мысалдар дәйектемелер ретінде назарға алынады. Тарбағатай ауданының аумағында орналасқан елді мекендердің атауларының қойылуы топонимдік миф, аңыз, әпсана түрінде айтылып, ел жадында сақталып келгендігі мысалға келтіріліп, талдаулар жасалады. ХҮІІІ ғасырдағы Ресей зерттеушілерінің еңбектеріндегі Алтай мен Тарбағатай, Зайсан туралы қағаз бетіне түскен алғашқы деректерден мысалдар келтіріледі. Топонимдік аңыз, әсаналарға жататын Асан қайғының жер туралы айтқан сындары, Толағай туралы аңыздарындағы ақпараттық-деректік мәліметтер жинақталады. Жүз томдық «Бабалар сөзі» жинағының топонимдік аңыздарға арналған томдарына кірген мәтіндер мысалға алынады. Ел аузындағы Толағай туралы аңыз нұсқалары салыстырылды, шығу тегі түсіндіріледі. Тарбағатай топонимдік аңыздарының ішінде көп ұшырасатын Арғанаты атауына қатысты аңыздар жүйеленді. «Арғанаты» атауын зерттеу барысында М.Қашғари сөздігі, академик Ә.Қайдар мен ғалым А.Әбдрахманов, Т.Жанұзақтың талдаулары негізге алынды.
Assessing knowledge about self-regulated learning: validation of a measurement tool for preschoolers
Authors: Grüneisen Lena , Dörrenbächer-Ulrich Laura , Kapsali Efsevia , Perels Franziska 
Published: February 2024

IntroductionSelf-regulated learning (SRL), as the self-directed and goal-orientated control of one’s learning process, is an important ability for academic success. Even at preschool age, when its development is at a very early stage, SRL helps to predict later learning outcomes. Valid test instruments are needed to identify preschoolers who require SRL support and help them to start school successfully.MethodsThe present study aimed to provide an adequate SRL test instrument for preschoolers by revising and optimizing an existing strategy knowledge test and validating the revised version–the SRL Strategy Knowledge Test—in a sample of n = 104 German preschoolers (Mage = 5;11 years; 48.1% girls). For the validation, we used measures of (1) SRL and related constructs, (2) psychomotor development, and (3) academic competence, to determine three levels of validity: (a) convergent, (b) divergent, and (c) criterion. All the correlation analyses controlled for child intelligence.ResultsThe results showed that the test is of moderate difficulty and sufficiently reliable (Cronbach’s α = 0.74), can generate normally distributed data, and has a one-factor structure. In line with our hypotheses, we found significant correlations for the convergent and criterion measures, and numerically smaller and insignificant correlations for divergent measures. The correlations for the criterion measures failed to be significant when controlling for intelligence.DiscussionThe missing evidence for criterion validity when controlling for intelligence may have been due to limitations in the measures used to examine criterion validity. The SRL Strategy Knowledge Test can be used in practice to diagnose the need for SRL support and in future studies and interventions on SRL development.
Remote detection and monitoring of post-mining heat island
Authors: Worsa-Kozak Magdalena , Górniak-Zimroz Justyna , Szrek Aleksandra , Chudy Krzysztof 
Published: February 2024

Underground hard coal mining activity in southern Poland has lasted more than 200 years. Among many factors related to mining and influencing the natural environment, the longest-active are coal waste heaps and tailings ponds. Several hundred objects are inventoried in Lower and Upper Silesia, of which 109 are located in the Lower Silesian Coal Basin (LSCB). These remnants of mining activity are built of gangue, waste coal, and coal silt (post-mining wastes). They cause environmental hazards, i.e., soil, air, groundwater, and surface water pollution in the storage area. They also tend to combust spontaneously, emitting enormous amounts of greenhouse gases into the atmosphere and increasing their neighborhood’s air, soil, and water temperature. Indigenous fires occur more than 20 years after the end of the waste disposal phase. The post-mining heat island (PMHI) phenomena, related to thermal activity development of the post-coal mining heaps and tailings ponds, is still under-recognition and research. Therefore, our study aims to improve and develop a methodology for remote detection and monitoring of heat islands resulting from coal mining operations to track the thermal activity of heaps and tailings ponds in LSCB from mines closure to 2023. The study used open satellite data from the Landsat program to identify and track post-mining heat islands over 23 years within the former mining area and verify the results within the borders of the inventoried heaps and tailings ponds. As a result, geospatial analysis on a time scale was carried out to identify post-mining hot spots. The self-heating intensity index (SHII) and the air temperature thermal indicator (ATTI) were calculated for identified and confirmed objects. SHII ranged between 0.00 and 10.07, and ATTI, on the other hand, varied from −12.68 to 25.18. Moreover, maps of the thermal activity of selected heaps were developed, the characteristics of the self-combustion phenomena were identified, and the remote detection of PMHI and its monitoring methodology was developed. The provided method can be used in the future to regularly monitor coal mining areas to prevent and identify hazardous hot spots and verify the maturity stage of the self-combustion processes.
Integrated multiomic analysis reveals disulfidptosis subtypes in glioblastoma: implications for immunotherapy, targeted therapy, and chemotherapy
Authors: Yang Xue , Cai Zehao , Wang Ce , Jiang Chenggang , Li Jianguang , Chen Feng , Li Wenbin 
Published: February 2024

IntroductionGlioblastoma (GBM) presents significant challenges due to its malignancy and limited treatment options. Precision treatment requires subtyping patients based on prognosis. Disulfidptosis, a novel cell death mechanism, is linked to aberrant glucose metabolism and disulfide stress, particularly in tumors expressing high levels of SLC7A11. The exploration of disulfidptosis may provide a new perspective for precise diagnosis and treatment of glioblastoma.MethodsTranscriptome sequencing was conducted on samples from GBM patients treated at Tiantan Hospital (January 2022 - December 2023). Data from CGGA and TCGA databases were collected. Consensus clustering based on disulfidptosis features categorized GBM patients into two subtypes (DRGclusters). Tumor immune microenvironment, response to immunotherapy, and drug sensitivity were analyzed. An 8-gene disulfidptosis-based subtype predictor was developed using LASSO machine learning algorithm and validated on CGGA dataset.ResultsPatients in DRGcluster A exhibited improved overall survival (OS) compared to DRGcluster B. DRGcluster subtypes showed differences in tumor immune microenvironment and response to immunotherapy. The predictor effectively stratified patients into high and low-risk groups. Significant differences in IC50 values for chemotherapy and targeted therapy were observed between risk groups.DiscussionDisulfidptosis-based classification offers promise as a prognostic predictor for GBM. It provides insights into tumor immune microenvironment and response to therapy. The predictor aids in patient stratification and personalized treatment selection, potentially improving outcomes for GBM patients.