bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competitive adsorption of CO2, N2, and CH4 in coal-derived asphaltenes, a computational study
Authors: Valadi Farshad Mirzaee , Pasandideh-Nadamani Mohammad , Rezaee Mozafar , Torrik Abdolhalim , Mirzaie Mohammad , Torkian Ayoob 
Published: April 2024

AbstractGreenhouse gases are major contributors to global warming, and their concentration is increasing due to the widespread use of fossil fuels. Coal bed methane (CBM) offers a potential solution to this issue. However, the gas adsorption mechanisms of CBM, particularly in the context of coal-derived asphaltenes, are not fully understood. This study provides a comprehensive theoretical investigation of the competitive adsorption of carbon dioxide (CO$$_2$$

2

), methane (CH$$_4$$

4

), and nitrogen (N$$_2$$

2

) in the processes of CO$$_2$$

2

- and N$$_2$$

2

-enhanced coalbed methane recovery, with a focus on coal-derived asphaltenes functionalized with CH$$_4$$

4

, NH, O, and S groups. Using the Grand Canonical Monte Carlo (GCMC) simulation method and performing Molecular Dynamics (MD) simulations, we studied the adsorption process. To investigate the electronic effects and nature of the interactions, we performed density functional theory (DFT) calculations. The adsorption energy values and non-covalent interactions (NCI) for the adsorption of gases signify the physical adsorption (van der Waals interaction), with CO$$_2$$

2

exhibiting the highest (absolute) adsorption energy. The Monte Carlo results indicated that elevated temperatures led to a reduction in adsorption capacity. Coal-derived asphaltenes demonstrated greater selectivity for CO$$_2$$

2

compared to CH$$_4$$

4

and N$$_2$$

2

in competitive adsorption, especially at elevated temperatures. Our findings highlight the significant potential of our asphaltene model, not only in mitigating CO$$_2$$

2

greenhouse gas emissions but also in recovering CH$$_4$$

4

, which is a valuable resource.
Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation
Authors: Mortensen Janni Støvring , Bohr Søren S.-R. , Krog Lasse Skjoldborg , Bøtker Johan Peter , Kapousidou Vaya , Saaby Lasse , Hatzakis Nikos S. , Mørck Nielsen Hanne , Nguyen Duc Ninh , Rønholt Stine 
Published: April 2024

AbstractThe integrity of the intestinal mucus barrier is crucial for human health, as it serves as the body's first line of defense against pathogens. However, postnatal development of the mucus barrier and interactions between maturity and its ability to adapt to external challenges in neonatal infants remain unclear. In this study, we unveil a distinct developmental trajectory of the mucus barrier in preterm piglets, leading to enhanced mucus microstructure and reduced mucus diffusivity compared to term piglets. Notably, we found that necrotizing enterocolitis (NEC) is associated with increased mucus diffusivity of our large pathogen model compound, establishing a direct link between the NEC condition and the mucus barrier. Furthermore, we observed that addition of sodium decanoate had varying effects on mucus diffusivity depending on maturity and health state of the piglets. These findings demonstrate that regulatory mechanisms governing the neonatal mucosal barrier are highly complex and are influenced by age, maturity, and health conditions. Therefore, our results highlight the need for specific therapeutic strategies tailored to each neonatal period to ensure optimal gut health.
Effect of hydroxychloroquine blood concentration on the efficacy and ocular toxicity of systemic lupus erythematosus
Authors: Liu Peng-Cheng , Luo Shui-Lin , Lv Meng-Na , Wang Yan , Li Jian-Bin , Yu Shu-Jiao , Wu Rui 
Published: April 2024

AbstractIn the absence of evidence-based guidance on the impact of hydroxychloroquine (HCQ) blood concentration on efficacy and ocular toxicity in systemic lupus erythematosus (SLE), the clinical monitoring of HCQ blood concentration is not yet widely performed, which raised concerns about the necessity of conducting HCQ blood concentration monitoring. In this retrospective study, we consecutively enrolled 135 patients with SLE who received HCQ treatment for more than 6 months from July 2022 to December 2022. Ocular toxicity was evaluated by collecting relevant retinal parameters using optical coherence tomography angiography (OCTA). Therapeutic efficacy was evaluated using the SLE disease activity index (SLEDAI) and relevant clinical parameters. HCQ blood concentration was determined by high-performance liquid chromatography-tandem mass spectrometry (HPLC–MS/MS). Spearman correlation analysis revealed that the cumulative dose of HCQ was positively correlated with the foveal avascular zone (FAZ) perimeter and FAZ area (r = 0.734, P < 0.001; r = 0.784, P < 0.001). Meanwhile, the treatment duration of HCQ was positively correlated with FAZ perimeter and FAZ area (r = 0.761, P < 0.001; r = 0.882, P < 0.001). The univariate and multivariate logistic regression analyses indicated that HCQ blood concentration was associated with the disease activity of patients with SLE (odds ratio 0.994, 95% CI 0.990–0.999). HCQ blood concentration may be an important factor in assessing the therapeutic effectiveness of SLE patients. The HCQ-related ocular toxicity was a long-term effect related to long term exposure, rather than the blood concentration of HCQ at the time of testing. More importantly, when addressing HCQ-related ocular toxicity, it may be crucial to pay attention to the cumulative dose and treatment duration of HCQ.
Analysis of post-market adverse events of istradefylline: a real-world study base on FAERS database
Authors: Jiang Ying , Lu Rongrong , Zhou Qin , Shen Yuan , Zhu Haohao 
Published: April 2024

AbstractAnalyze the adverse event (AE) signals of istradefylline based on the FAERS database. By extracting large-scale data from the FAERS database, this study used various signal quantification techniques such as ROR, PRR, BCPNN, and MGPS to calculate and evaluate the ratio and association between istradefylline and specific AEs. In the FAERS database, this study extracted data from the third quarter of 2019 to the first quarter of 2023, totaling 6,749,750 AE reports. After data cleansing and drug screening, a total of 3633 AE reports related to istradefylline were included for analysis. Based on four calculation methods, this study unearthed 25 System Organ Class (SOC) AE signals and 82 potential preferred terms (PTs) related to istradefylline. The analysis revealed new AEs during istradefylline treatment, including reports of Parkinsonism hyperpyrexia syndrome (n = 3, ROR 178.70, PRR 178.63, IC 1.97, EBGM 165.63), Compulsions (n = 5, ROR 130.12, PRR 130.04, IC 2.53, EBGM 123.02), Deep brain stimulation (n = 10, ROR 114.42, PRR 114.27, IC 3.33, EBGM 108.83), and Freezing phenomenon (n = 60, ROR 97.52, PRR 96.76, IC 5.21, EBGM 92.83). This study provides new risk signals and important insights into the use of istradefylline, but further research and validation are needed, especially for those AE that may occur in actual usage scenarios but are not yet explicitly described in the instructions.
Intensity-tunable achromatic cascade liquid crystal Pancharatnam-Berry lens
Authors: Mo Zhichang , Zhao Yuanan , Wang Jianguo , Liu Xiaofeng , Cheng Changjie , Chen Yi , Zhu Xiangyu , Zhao Yadi , Wang Kun , Ou Shaozhong , Zhang Zhouhao , Cao Zhaoliang , Cao Qing , Shao Jianda 
Published: April 2024

AbstractIn the current solution for multiwavelength achromatic flat lenses, a one-to-one correspondence exists between the number of writing phase distributions and the number of achromatic wavelengths. Breaking this correspondence requires a complex phase design and parameter optimization. Here, we show that a dual-layer cascade liquid crystal Pancharatnam-Berry lens (CLCPBL) with two writing phase distributions and a specific coupled phase distribution between the layers can achieve three wavelength achromaticity without any parameter optimization process. Similarly, in a three-layer cascade, the number of achromatic wavelengths increases to seven through the permutations of the layers, with adjustable amplitude factors. We fabricate a three-layer CLCPBL with the design wavelengths of 396.8 nm, 1064 nm, and 1550 nm, which theoretically allows the light at 632.8, 532.8, 3383 and 450 nm to form a common focus, and test such structure. Our CLCPBL enables a wider range of applications than conventional achromatic flat lenses.
Sulfide saturation and resorption modulates sulfur and metal availability during the 2014–15 Holuhraun eruption, Iceland
Authors: Nicholson Emma J. , Wieser Penny E. , Hartley Margaret E. , Jenner Frances E. , Kunz Barbara E. , Ilyinskaya Evgenia , Thordarson Thorvaldur , Edmonds Marie 
Published: March 2024

AbstractMafic magmas may experience multiple stages of sulfide saturation and resorption during ascent and differentiation. Quenched tephra erupted during the 2014–15 Holuhraun eruption preserve abundant evidence for sulfide resorption, offering a rare opportunity to explore the sulfide life cycle from nucleation to resorption. Specifically, we combine detailed textural and chemical analyses of sulfides and silicate melts with geochemical models of sulfide saturation and degassing. This integrative approach demonstrates that sulfides began nucleating in melts with ~8 wt% MgO, persisted during fractionation to 6.5 wt% MgO, before resorbing heterogeneously in response to sulfur degassing. Sulfides are preserved preferentially in confined geometries within and between crystals, suggesting that kinetic effects impeded sulfur loss from the melt and maintained local sulfide saturation on eruption. The proportion of sulfides exhibiting breakdown textures increases throughout the eruption, coincident with decreasing magma discharge, indicating that sulfide resorption and degassing are kinetically limited. Sulfides likely modulate the emission of sulfur and chalcophile elements to the atmosphere and surface environment, with implications for assessing the environmental impacts and societal hazards of basaltic fissure eruptions.
A Preliminary Study of Voluntary Cough Motor Performance and Learning With Skill Training and Biofeedback
Authors: Borders James C. , Lowell Emilie R. , Huber Jessica E. , Quinn Lori , Michelle S. Troche  
Published: April 2024

Purpose:
Sensorimotor cough skill training (CST) has been shown to improve cough strength, as well as facilitate changes during training (i.e., motor performance) and generalization to untrained tasks (i.e., motor learning). However, there is a gap in our understanding of the effects of voluntary CST (without sensory stimuli) on motor performance and learning. Furthermore, the contribution of physiologic factors, such as lung volume, a driver of cough strength in healthy adults, and treatment-specific factors, such as biofeedback, remains unexamined.

Method:

Twenty individuals with Parkinson's disease (PD) completed pre- and post-CST single voluntary, sequential voluntary, and reflex cough testing. Participants were randomized to
biofeedback
or
no biofeedback
groups. They completed one CST session involving 25 trials of voluntary coughs, with the treatment target set 25% above baseline peak flow. Participants were instructed to “cough hard” to exceed the target. In the

biofeedback group, participants received direct visualization of the target line in real time.

Results:
Cough peak flow showed positive improvements in motor performance (β = .02; 95% credible interval [CI]: 0.01, 0.03) and learning (β = .26; 95% CI: 0.03, 0.47). Changes in lung volume from pre- to post-CST did not predict treatment response. No differences in treatment response were detected between the biofeedback groups.

Conclusions:
A single session of voluntary CST improved voluntary cough motor performance and learning. Although lung volume increased during CST, changes to lung volume did not predict treatment response. These findings demonstrate the potential of voluntary CST to improve motor performance and motor learning among individuals with PD and cough dysfunction.

Supplemental Material and Open Science Form:

https://doi.org/10.23641/asha.25447444
Elite‐guided equilibrium optimiser based on information enhancement: Algorithm and mobile edge computing applications
Authors: Wang Zong‐Shan , Li Shi‐Jin , Ding Hong‐Wei , Dhiman Gaurav , Hou Peng , Li Ai‐Shan , Hu Peng , Yang Zhi‐Jun , Wang Jie 
Published: April 2024

AbstractThe Equilibrium Optimiser (EO) has been demonstrated to be one of the metaheuristic algorithms that can effectively solve global optimisation problems. Balancing the paradox between exploration and exploitation operations while enhancing the ability to jump out of the local optimum are two key points to be addressed in EO research. To alleviate these limitations, an EO variant named adaptive elite‐guided Equilibrium Optimiser (AEEO) is introduced. Specifically, the adaptive elite‐guided search mechanism enhances the balance between exploration and exploitation. The modified mutualism phase reinforces the information interaction among particles and local optima avoidance. The cooperation of these two mechanisms boosts the overall performance of the basic EO. The AEEO is subjected to competitive experiments with state‐of‐the‐art algorithms and modified algorithms on 23 classical benchmark functions and IEE CEC 2017 function test suite. Experimental results demonstrate that AEEO outperforms several well‐performing EO variants, DE variants, PSO variants, SSA variants, and GWO variants in terms of convergence speed and accuracy. In addition, the AEEO algorithm is used for the edge server (ES) placement problem in mobile edge computing (MEC) environments. The experimental results show that the author’s approach outperforms the representative approaches compared in terms of access latency and deployment cost.
Lexicon‐based fine‐tuning of multilingual language models for low‐resource language sentiment analysis
Authors: Dhananjaya Vinura , Ranathunga Surangika , Jayasena Sanath 
Published: April 2024

AbstractPre‐trained multilingual language models (PMLMs) such as mBERT and XLM‐R have shown good cross‐lingual transferability. However, they are not specifically trained to capture cross‐lingual signals concerning sentiment words. This poses a disadvantage for low‐resource languages (LRLs) that are under‐represented in these models. To better fine‐tune these models for sentiment classification in LRLs, a novel intermediate task fine‐tuning (ITFT) technique based on a sentiment lexicon of a high‐resource language (HRL) is introduced. The authors experiment with LRLs Sinhala, Tamil and Bengali for a 3‐class sentiment classification task and show that this method outperforms vanilla fine‐tuning of the PMLM. It also outperforms or is on‐par with basic ITFT that relies on an HRL sentiment classification dataset.
Pruning‐guided feature distillation for an efficient transformer‐based pose estimation model
Authors: Kim Dong‐hwi , Lee Dong‐hun , Kim Aro , Jeong Jinwoo , Lee Jong Taek , Kim Sungjei , Park Sang‐hyo 
Published: April 2024

AbstractThe authors propose a compression strategy for a 3D human pose estimation model based on a transformer which yields high accuracy but increases the model size. This approach involves a pruning‐guided determination of the search range to achieve lightweight pose estimation under limited training time and to identify the optimal model size. In addition, the authors propose a transformer‐based feature distillation (TFD) method, which efficiently exploits the pose estimation model in terms of both model size and accuracy by leveraging transformer architecture characteristics. Pruning‐guided TFD is the first approach for 3D human pose estimation that employs transformer architecture. The proposed approach was tested on various extensive data sets, and the results show that it can reduce the model size by 30% compared to the state‐of‐the‐art while ensuring high accuracy.
Coordination of aluminium crusher and battery energy storage system to provide multistage power system services
Authors: Rubasinghe Osaka , Zhang Tingze , Zhang Xinan , Chau Tat Kei , Chow Yau , Fernando Tyrone , Iu Herbert Ho‐Ching 
Published: April 2024

AbstractAncillary service provision and peak shaving (PS) play essential roles in the current day‐to‐day power system operation, which is challenged by the increasing renewable generation penetration. Providing these critical services using classical approaches such as peak load generators has been limited due to high operational costs and environmental impacts. The use of battery energy storage systems (BESS) is another popular method that is limited by high initial investment costs and high degradation rates. In this work, a novel approach to utilize industrial loads and BESS to provide multiple power system services in different stages is proposed. Industrial loads such as aluminium crushers are known for their intensive electricity consumption. Nevertheless, when applied in frequency regulation (FR), they perform poorly due to their discrete nature in operation. This drawback and the aforementioned BESS shortcomings are addressed by combining on‐site BESS with plant machinery to provide FR services and recover BESS related costs. Later, depending on the optimal capacity distribution, BESS usage is extended into the energy arbitrage market to provide PS services. This approach resulted in higher earnings for participating customers and network operators, as well as in less emissions, and minimal BESS degradations. An Australian case study of the South West Interconnected System, along with Worsley Alumina refinery data of Western Australia has been used to showcase the model performances.
Synergetic optimisation of mechanical and electrical properties of aramid composite insulation paper by modulation of fibrid morphology
Authors: Huang Meng , Yao Yuanxin , Wang Lu , Li Sai , Su Yanxiao , Ma Jie 
Published: April 2024

AbstractThe fibrids in aramid insulation paper exhibit good adhesion ability. However, the effects of fibrids morphology on the mechanical and electrical properties of aramid insulation paper remains poorly understood. Aramid fibrids with different morphological structures were prepared by modifying the preparation process, and then they were used to fabricate aramid composite insulation paper under the same condition. The results showed that increasing the shear rate and aramid solution concentration affected the magnitude of the shear force and double diffusion process, thus affecting the average length, specific surface area, and crystallinity of the fibrids. When the rotor frequency is 25–30 Hz and the solution concentration is 15%, the fibrid has a large specific surface area while ensuring high crystallinity, which is beneficial to the improvement of breakdown strength. When the average length of fibrids is 0.8–1.4 mm, the fine content is 1.3%–2.3%, specific surface area is 57.5–62 m2 g−1, and crystallinity is 18.5%–27%, the aramid composite insulation paper has the optimal mechanical and electrical properties. Combined with the micromorphology test results, the influence mechanism of fibrids properties on the mechanical properties, dielectric properties, and AC and DC breakdown strength of aramid composite insulation paper was obtained. The result is of great theoretical significance and practical value for the preparation and application of high‐performance aramid composite insulation paper.
Unusual Metastatic Sites and Radioiodine Uptake in Patients of Differentiated Thyroid Carcinoma with Atypical Clinical Presentations: Utilization of 131I-Whole-Body Scintigraphy with Regional SPECT/CT
Authors: Edamadaka Yeshwanth , Parghane Rahul V. , Basu Sandip 
Published: April 2024

AbstractDifferentiated thyroid carcinoma (DTC) usually is slow growing and carries a good prognosis. It most commonly tends to spread locally to regional lymph nodes in 20 to 60% of patients. The presence of distant metastasis impacts overall survival and prognosis. The lungs, bones, and the brain are typically involved in distant sites with less common metastatic sites that include the liver, kidney, skeletal muscle, adrenal glands, bladder, and skin. These unusual sites are rare and pose a diagnostic challenge and impact clinical decision-making to a great extent. The radioiodine 131I whole-body scintigraphy with single-photon emission computed tomography/computed tomography can provide a thorough investigation of unusual sites of uptake leading to diagnosis of these metastases. We present a case series of DTC showing unusual sites of metastasis and/or radioiodine uptake in urinary bladder, in the third metacarpal bone of left hand and lastly in the forearm at postoperative hypertrophic scar area.
Research on the Mechanism of Si Xian Decoction in Treating Acute Leukemia Based on Network Pharmacology and Molecular Docking Technology
Authors: Jiang Zihan , Zhang Man , Guo Jiayuan , Liu Mingxin , Liu Wenqing , Guo Jue , Ma Qiuling 
Published: March 2024

Abstract
Objective Our objective was to investigate the mechanism of action of the Si Xian Decoction (SXD) in treating acute leukemia (AL) using network pharmacology and molecular docking techniques.
Methods The chemical components of the four medicinal herbs of Shengdi (Rehmanniae Radix), Baimaogen (Imperatae Rhizoma), Xiaoji (Cirsii Herba), and Pugongying (Taraxaci Herba) in the SXD were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine (BATMAN-TCM), and Encyclopedia of Traditional Chinese Medicine (ETCM). A natural active chemical component dataset for the SXD was established. Human Gene Database (Gencards), Database of Gene-Disease Associations (DisGeNET), Database for Drug and Drug Target Information (DrugBank), and Human Disease Database (MalaCards) were searched to obtain AL-related targets and to establish a disease target database. After obtaining the intersection targets of drugs and diseases, a Venn diagram of the common targets was drawn online. A drug-disease protein interaction network was constructed using the String 11.5 platform, and a “drug-disease-target-signal pathway” network was built using Cytoscape 3.8.2 software to obtain relevant target network topology parameters.
Results By searching the TCMSP, BATMAN-TCM, and ETCM databases, 30 active components of the SXD and 677 related targets were obtained. From Gencards, DrugBank, MalaCards, and DisGeNET databases, 12,110 potential AL disease targets were obtained. Using the ClusterProfiler package of the R4.2.2 platform, 1,011 entries of gene ontology information were enriched, including 467 biological process entries, 236 molecular function entries, and 308 cellular component entries. Additionally, 220 enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways were obtained, mainly involving chemical carcinogen receptor activation, lipid and atherosclerosis, fluid shear stress and atherosclerosis, prostate cancer, and the role of the advanced glycation end products-receptor for advanced glycation end products (AGE-RAGE) signaling pathway in diabetic complications. Network topology analysis revealed that the main active components of SXD treating AL include γ-aminobutyric acid, adenosine, quercetin, scopolamine, and taraxasterol.
Conclusion The treatment of AL with the SXD is a process of multicomponent, multitarget, and multisignal pathway coordination. Network pharmacology provides a solid research basis for elucidating the mechanism of action of SXD in the treatment of AL.