bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and histological evaluation of portwine stain treatment with a microsecond‐pulsed dye‐laser at 577 NM
Authors: Henning J. P. Hulsbergen , van Gemert M. J. C. , Lahaye C. T. W. 
Published: March 2007

AbstractTest treatment of portwine stains (PWS) was performed with a microsecond‐pulsed dye laser at 577nm using a 2‐mm spot diameter. Although selective coagulation of the erythrocytes occurred, this did not result in bleaching of the treated area. Massive destruction of the dilated capillaries is suggested to be a prerequisite for PWS‐bleaching, very probably requiring msec (instead of μsec) laser pulses.
Extensive granuloma pyogenicum as a complication of endolaryngeal argon laser surgery
Authors: Dejonckere P. H. , Franceschi D. , Scholtès J. L. 
Published: March 2007

AbstractA case report of an exuberant anterior transglottic granuloma pyogenicum as a complication of endoscopic argon laser surgery for an anterior web, after previous treatments of juvenile laryngeal papillomatosis, is described.
Potentiation of photodynamic therapy by heat: Effect of sequence and time interval between treatments in vivo
Authors: Waldow Stephen M. , Henderson Barbara W. , Dougherty Thomas J. 
Published: March 2007

AbstractPhotodynamic therapy (PDT) utilizing hematoporphyrin derivative (Hpd) as photosensitizer and an argon‐dye laser as the light source was used alone and in combination with a localized microwave hyperthermia treatment to treat the SMTF mammary carcinoma in mice. A 30‐min heat treatment at 44.5°C was applied 0–8 hr before or after a standard photodynamic treatment (67.5 or 135 J/cm2, given 24 hr post‐7.5 mg/kg Hpd). Potentiation of PDT by heat was found to be related to the sequence of the treatments and the time interval between them.When 44.5°C for 30 min was applied immediately after a 15‐min PDT treatment, significant potentiation was seen (58% long‐term tumor control vs 3 and 10%, respectively, for PDT and heat alone). This potentiation decreased with increasing time between PDT and heat, with tumor control values decreasing to 36, 20, and 14%, when 2, 4, and 8 hr, respectively, were allowed between treatments. Only additive effects of the independent therapies were found when this heat treatment was applied 0–8 hr before PDT.In other experiments, mice were treated with single or fractionated 30‐min PDT treatments (two 15‐min treatments separated by 0‐,‐2‐, 4‐, or 8‐hr intervals). Decreases in tumor control were seen with increasing time interval; only minor differences in tumor control were seen when 4–8 hr was allowed between treatments compared to a single 15‐min treatment.
Modeling of (coronary) laser‐angioplasty
Authors: van Gemert Martin J. C. , Schets Gert A. C. M. , Stassen Edmond G. , Bonnier Johannes J. 
Published: March 2007

AbstractA first attempt to describe (coronary) laser angioplasty is presented using simplified but standard optical and thermal modeling of tissue in interaction with a laser. Ablation behavior of blood thrombi and plaque has been approximated from numerical computations for various wavelengths representing the Ar, Nd‐YAG, and CO2 lasers. The overall results, in terms of calculated depth of ablation versus laser irradiation time, show a relatively fast initial process followed by a very slow one. The analysis suggests that a sequence of laser pulse‐catheter tip flushing should substantially increase the overall ablation velocity. The physics of threshold laser power and influence of laser beam diameter is discussed. A comparison between experimental results is made when possible. Suggestions for further test experiments are made.
Optical properties of human blood vessel wall and plaque
Authors: van Gemert Martin J. C. , Verdaasdonk Ruud , Stassen Edmond G. , Schets Gert A. C. M. , Gijsbers Geert H. M. , Bonnier Johannes J. 
Published: March 2007

AbstractOptical properties of blood vessel wall and plaque from human cadaver material are presented for the argon laser (514.5 nm), He‐Ne laser (633 nm), and the Nd‐YAG laser (1,060 nm) wavelengths. Measurements were performed with an integrating sphere arrangement and anlayzed in terms of Kubelka‐Munk absorption and scattering coefficients.
Vascular recanalization with the argon laser: The role of blood in the transmission of laser energy
Authors: Kaplan Michael D. , Case Robert B. , Choy Daniel S. J. 
Published: March 2007

AbstractSuccessful revascularization of stenosed arteries with the argon laser optical fiber catheter requires delivery of high‐power‐density energy to the lesion. Because of the high energy absorption by hemoglobin at the argon laser wavelengths, which would attenuate transmission of laser energy to the obstruction, we measured argon laser transmission through blood at different concentrations. We found that no transmission occurred through 1 mm of whole blood with hematocrit of 42 and that blood must be diluted to a hematocrit below 1 for laser energy to be delivered. Successful use of the intravascular argon laser is dependent on the creation of a transmission medium by displacement of blood by saline or other non‐absorbing substance.
Complete patency in thrombus‐occluded arteries two weeks after laser recanalization
Authors: Marco Jean , Silvernail Paul J. , Fournial Gerard , Choy Daniel S. J. , Fajadet Jean , Case Robert B. 
Published: March 2007

AbstractThe potential problem of rethrombosis after laser recanalization was studied in 16 thrombus‐occluded canine femoral arteries. Balloon de‐endothelialization and thrombin‐human blood injection produced adherent, completely occlusive thrombi 4.13 ± 1.54 cm in length; laser exposure of the thrombi occurred at 18.35 ± 22.1 hours. The argon laser catheter was introduced via a proximal arteriotomy and a power of 3.83 ± 0.58 W delivered for 411.3 ± 296.87 seconds. Follow‐up period was 14 days. All arteries were patent immediately after and 14 days following lasing, as demonstrated by angiography. There was no vessel perforation. Seven of the dogs were maintained on aspirin and dipyridamole 4 days before and throughout the study, but there were no differences in thrombus length, laser power, or duration of laser exposure between these dogs and those receiving no anti‐platelet therapy. Control thrombosed arteries (without laser energy application) showed no autolysis within 14 days in all dogs and up to 95 days in three dogs followed for this period of time.These data show that rethrombosis of totally occluded, thrombosed arteries is not present up to 2 weeks later after laser recanalization, with or without the aid of anti‐platelet therapy.
Laser applications to arteriosclerosis: Angioplasty, angioscopy, and open endarterectomy
Authors: Eugene John , McColgan Stephen J. , Hammer‐Wilson Marie , Moore‐Jeffries Earl W. , Berns Michael W. 
Published: March 2007

AbstractWe have studied laser radiation of arteriosclerotic cardiovascular disease to determine the best technique for evaluation. Rabbits with arteriosclerosis were treated by intraluminal laser angioplasty (N = 8), laser angioscopy (N = 2), and open laser endarterectomy (N = 5). All studies were performed with an argon ion laser delivering energy through a 400‐μm quartz fiber. Power delivered was varied in order to determine the best value for this animal model. Following angioplasty, perforation was seen in three rabbits (in one case, it was due to mechanical trauma from the fiber optic), and early thrombosis occurred in two rabbits. Plaques were vaporized by angioscopy, but the depth of laser beam penetration or angle of incidence could not be controlled. Open laser endarterectomy gave consistently good results with removal of an arteriosclerotic plaque within the media. The optimum power was found to be 1.0‐2.0 W. Endarterectomy required an energy density of 100‐140 J/cm2. We conclude that open laser endarterectomy can be a standardized technique for the in vivo evaluation of laser radiation upon arteriosclerotic lesions.
Responses of atherosclerotic aorta to argon laser
Authors: Dries David J. , Lawrence Peter F. , Syverud John , Moatamed Farhad , Dixon John 
Published: March 2007

AbstractLasers have been advocated to resect atherosclerotic plaques in the cardiovascular system, yet little information is available regarding the effects of laser on the range of occlusive lesions seen in the peripheral arterial tree. This study was conducted to assess the risk of perforation in human cadaveric aorta involved with variable degrees of atherosclerosis. Ten fresh segments of atherosclerotic human aorta were graded for extent of atherosclerosis, then subjected to argon laser energy within 48 hours. Using air as the conduction medium and with the fiber tip 2 or 5 mm from the vessel wall, the argon laser was applied to matched calcified and non‐calcified arteries at 3.0‐7.0 W and 10.0–13.5 W with energy density identical for matched pairs. Results were compared among segments which were normal in appearance or had only fatty streaks grossly with those with gross regional wall calcification. The mean penetration time (T) for calcified and non‐calcified lesions at low and high power outputs was compared.magnified imageMean time to perforation and range of time necessary to produce perforation were greater in calcified than non‐calcified segments at all power levels employed. These data suggest that atherosclerotic lesions vary in their response to argon laser. The presence of calcium may preclude resection of some plaques and protect against wall perforation.
Histological studies of myocardium zones irradiated with Nd–YAG laser
Authors: Obelienius V. , Knepa A. , Lubite Y. , Ambartzumian R. , Isakov V. , Koshelev E. , Markin E. 
Published: March 2007

AbstractHistological investigation of the dog's myocardium performed 7 and 25 days after irradiation with different doses of Nd‐YAG laser show that the damage zone has the shape of a hollow sphere with minor changes in cardiomyocytes in the central part of the sphere. The small blood vessels in the irradiated zone remained undamaged as well. A tentative explanation of the physical process that leads to this type of coagulation zone is given.
Photodynamic therapy of gynecologic neoplasms after presensitization with hematoporphyrin derivative
Authors: McCaughan James S. , Schellhas Helmut F. , Lomano Jack , Bethel Bradley H. 
Published: March 2007

AbstractFive patients with various gynecologic neoplasms were treated with photodynamic therapy using 630‐nm light delivered from an argon dye laser system following the intravenous injection of hematoporphyrin derivative (HpD). A patient with multifocal squamous cell cancer of the vagina had no evidence of disease 15 months after her first photodynamic therapy treatment. Autopsy nine months after the first treatment of another patient with multifocal invasive cancer of the vagina and parametrium showed no evidence of tumor on the surface of the vagina. Eight months after treatment of an 8 × 12 cm area of Bowen's disease of the vulva and thigh, there was no evidence of disease. Vaginal bleeding from breast cancer metastatic to the endometrium was controlled by one treatment until the patient expired five months later from her disease. Adenocarcinoma metastatic to the vaginal cuff showed partial response when vaginectomy was performed five weeks after photodynamic therapy.
Use of Nd:YAG laser in pancreatic resections with duodenal preservation in the dog
Authors: Berlatzky Yacov , Muggia‐Sullam Michael , Munda Rino , Joffe Stephen N. 
Published: March 2007

AbstractThe trend in recent years for treatment of pancreatic carcinoma and occasionally for pancreatitis has been towards total pancreatectomy. The pancreas is also now being harvested for transplantation. Any operative technique that can reduce operating time, blood loss, and associated morbidity and mortality would be of tremendous advantage. The aim of this study was to undertake a total pancreatectomy using the Nd:YAG laser (wavelength 1,060 nm) with a helium neon laser (wavelength 628 nm) incorporated to provide a marker beam. The laser beam was passed into a 400 μm flexible glass fiber enclosed in a 2.5 mm polyethylene cannula, which also served as a conduit for coaxial CO2. The laser was operated in a continuous wave mode, and the fiber exit beam had a divergence of 10°. For photocoagulation and tissue vaporization, peak powers of 50 W were used with 0.5–1 sec pulses. The total pancreatectomy using the Nd:YAG laser was performed in eight dogs, and ten dogs undergoing the conventional operative procedure served as controls. The findings indicate that the Nd:YAG laser could be used effectively and safely. The operating time was considerably diminished (P < 0.01); the number of ligatures used was smaller; blood loss, graft survival, and duodenal viability were similar. The Nd: YAG laser offers a new therapeutic modality in the performance of tedious and often difficult pancreatic surgery.
CO2 laser vaporization for chronic cervicitis
Authors: Rubinstein Eli 
Published: March 2007

AbstractChronic cervicitis is the most common disease occurring during the period of greatest sexual activity and reproductivity, and it is the most common gynecologic disease in young women. The disease is a common sequel to normal delivery and one of the main causes of infertility; it also may be precancerous.All the treated women in the present study exhibited preoperatively severe subjective symptoms for chronic cervicitis, and 32 out of 60 (53%) exhibited colposcopically atypical squamous epithelium. The women were examined 3, 6, and 12 months following laser surgery: 58 (97%) of them reported a decreasing intensity of their symptoms, and colposcopy revealed a normal postlaser transfor‐ mation zone as well as a decreasing edema of cervical epithelium.
Effect of low‐dose argon irradiation on rate of wound closure
Authors: McCaughan James S. , Bethel Bradley H. , Johnston Timothy , Janssen William 
Published: March 2007

AbstractFour open circular wounds were made on the backs of each of ten guinea pigs by excising approximately 2‐cm areas of full‐thickness skin and subcutaneous tissue. Every 2 or 3 days, one of the four wounds was treated with 2 J/cm2 argon laser, one washed and treated, one only washed, and one receiving no treatment. The area of the remaining open wound was traced on a glass microslide. A tenth guinea pig received the same „treatments”︁ but the laser was not turned on. The wounds receiving different treatments were randomly selected on different guinea pigs. The area of open wound remaining was measured with a planimeter, and the rate of healing was plotted for each. The numbers of days required for 50 and 75% healing were determined. All wounds were coded and the results determined by an independent observer. We found no difference in the rate of healing of any of these wounds and, under these experimental conditions, found no effect on the overall rate of wound healing by low‐dose argon laser exposure.
Toward the ideal treatment for the port wine stain with the argon laser: Better prediction and an “optimal” technique
Authors: Carruth J.A.S. , Shakespeare P. 
Published: March 2007

AbstractTreatment of the port wine stain with the argon laser still remains more of an art form than a scientific technique. Already, some very satisfactory results are being obtained, and these will be improved by greater accuracy in predicting those patients who will respond well to argon laser therapy and by the development of an optimal treatment technique.
Laser treatment of discoid lupus (case report)
Authors: Henderson Darrell L. , Odom James C. 
Published: March 2007

AbstractThis is a case report of vaporization of the characteristic disfiguring plaques of discoid lupus erythematosis (DLE) with the carbon dioxide laser. This patient had a dramatic clinical and cosmetic improvement. It is suggested that the altered but not vaporized cells that remained were responsible for the retardation of the disease process.
Argon laser treatment of superficial vascular lesions in children
Authors: Hobby Lovic W. 
Published: March 2007

AbstractThe author's experience in the use of the argon laser in the treatment of superficial vascular lesions in children is reviewed. Deteriorating portwine stains, strawberry hemangiomas, other hemangiomas, telangiectasias, and other lesions are discussed. Their natural histories are discussed. Details are given regarding indications for therapy, techniques, and postoperative results.
Argon laser photocoagulation of port wine stain hemangiomas
Authors: Silver Lester 
Published: March 2007

AbstractA total of 66 patients with port wine stains is reported. All of these were tested and 46 patients treated (80 treatments). Good to excellent results (significant lightening of color and/or smoother texture of skin) was achieved in 74% of tests (0 scar) and in 82% of treatments (4.3% scar). Treatment results correlate well with test spots but vary somewhat as the lesions are not homogenous and skin textures vary. The lowest energy density commensurate with successful treatment should be used to reduce the incidence of scarring. Future methods of manipulating the PWS may make it possible to achieve better results with less scarring. Teenagers fared well in this series, while the problem of successful treatment in the young child remains unsolved.
Possible hazards from irradiation with the carbon dioxide laser
Authors: Walker Neil P. J. , Matthews Julie , Newsom S.W.B. 
Published: March 2007

AbstractPrevious investigators, using relatively high irradiance levels, have been unable to demonstrate viable tissue in the plume during carbon dioxide laser vaporization. Our study was undertaken to reinvestigate this possibility, particularly at the lower irradiance levels that are currently in clinical use. Fresh post‐mortem skin was injected with a known quantity of bacterial spores and vaporized at different levels of irradiance and energy fluence. The plume and splatter were collected and cultured. Spores were found following the vaporization of five of 13 specimens treated at an irradiance of <500 W/cm2, while there were none in the 20 specimens treated at an irradiance of >997 W/cm2. These results show that the widely accepted assumption that the carbon dioxide laser produces a sterile field may be false and that viable particles may be disseminated during vaporization at low irradiance. This may be important when considering the treatment of potentially infectious lesions.
The effect of CO2 laser excision on local tumor recurrence
Authors: Lanzafame Raymond J. , Rogers David W. , Naim John O. , Raul Herrera H. , Defranco Cecelia , Raymond Hinshaw J. 
Published: March 2007

AbstractThis study was undertaken to determine the effect of CO2 laser surgery on the incidence of local recurrence following tumor recurrence and to study the effect of “sterilization” of the operative site on this phenomenon. Sixty Fisher 344 rats were implanted with R323OAC mammary carcinoma. Animals were anesthetized with intraperitoneal pentobarbital, and all tumors were completely excised at 21 days postimplantation.The animals were randomized into groups of 12 as follows: Group S underwent excision with the scalpel. Group E underwent excision with electrocautery (Bovie, Valley Labs, Boulder, CO). Group L and LV underwent excision with the Sharplan 733 CO2 laser (Laser Industries, Israel) (TEMoo, 125‐mm handpiece, 25‐W continuous wave). Group LV wounds were then “sterilized” by using the laser defocused to a 5‐mm spot size and gently heating the site without producing blanching or charring of the tissues.Primary tumor size was 2.0 ± 0.5 cm and was similar in all groups. Animals were observed for recurrence for 33 days postoperatively. Mortalities were excluded from analysis. Tumors recurred in 7/9 (78%) in group S, 5/11 (45%) in group E, 4/10 (40%) in group L, and only 1/12 (8%) in group LV. AH results are significant at P<0.05. The CO2 laser is an effective surgical adjunct to reduce local tumor seeding and recurrence. This effect is enhanced by “sterilizing” the surgical site with the defocused laser beam.
Management of vulvar condylomata acuminata with argon laser
Authors: Rotteleur G. , Riboulet J. L. , Vanlerberghe K. , Pollet M. , Lemaire B. , Brunetaud J. M. 
Published: March 2007

AbstractOne hundred and one female patients with vulvar condylomata acuminata were treated with the argon laser. Most were managed under regional or general anesthesia because of the large size and extent of the warts. Ten patients were lost to follow‐up after the first session. Of 91 other patients, 78 (86%) were free of lesions on follow‐up examinations after one or two treatments. The 13 other patients had recurrent lesions: seven patients underwent three laser sessions; four required four sessions, and 2 others required five and six sessions, respectively. These results were comparable with those achieved with the carbon dioxide laser.
The use of the carbon dioxide laser in head and neck lymphangioma
Authors: White Benjamin , Adkins Warren Y. 
Published: March 2007

AbstractThe carbon dioxide laser has been used to treat various lesions of the head and neck, ranging from carcinomas to hemangiomas, and even including tatoos. A search of the literature does not reveal any reports of the carbon dioxide laser being used to treat lymphangioma. This report discusses the efficacy of treating lymphangioma of the air and food passages with the carbon dioxide laser, and presents three patients who have been treated in this fashion—two for palliation and one for cure.
Nd‐YAG laser application in pulmonary and endobronchial lesions
Authors: Kao Shang‐Jyh , Shen Chien‐Yeh , Hsu Kang 
Published: March 2007

AbstractFor recurrent pulmonary bleeding and recanalization of centrally obstructed or stenosed airways, endobronchial Nd‐YAG laser irradiation through fiberoptic bronchoscopy was performed on 25 patients with malignant (n = 21) and benign (n = 4) disease of tracheobronchial lesions under topical anesthesia.Complete (n = 12) and partial (n = 6) restoration of the airway occurred in all 25 patients after photoresection therapy. For two patients with recurrent bleeding, the therapy resulted in immediate arrest of bleeding. For five patients the therapy resulted in unsuccessful recanalization because of rapidly recurring tumors.Two patients' conditions were complicated by respiratory insufficiency, one caused by smoke intoxication during laser vaporization and the other caused by tenacious rubberlike fibrinous plaque within a day after laser treatment. There was no mortality or perforation of the tracheobronchial wall after laser irradiation.Nd‐YAG laser provides an additional tool in the palliative therapy for unresectable, obstructive malignant tumors and a procedure for avoiding extensive surgery in benign lesions.