bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of procedural and informational justice in the integration of related acquisitions
Authors: Ellis Kimberly M. , Reus Taco H. , Lamont Bruce T. 
Published: November 2008

AbstractThis study explores the independent and interactive effects of procedural justice and informational justice on post‐deal value creation in large, related acquisitions. Our results show that informational justice and procedural justice affect different components of value creation. Procedural justice is critical in realizing market position improvements following the integration process, while informational justice is essential in achieving market position gains during integration and financial return gains both during and post‐integration. Indicating that the interrelationships between different justice dimensions may be more complex than previously thought, we find that procedural justice reduces the positive effects of informational justice on financial return during the integration process, while it magnifies the effects of informational justice on the combined firms' market position during integration efforts. We explore the implications of these results for future research on the acquisition integration process and for practicing managers engaging in large, related acquisitions. Copyright © 2008 John Wiley & Sons, Ltd.
Towards an improved understanding of statistical extrapolation for wind turbine extreme loads
Authors: Fogle Jeffrey , Agarwal Puneet , Manuel Lance 
Published: November 2008

AbstractOne of the load cases that must be evaluated per the International Electrotechnical Commission standard for wind turbine design requires that characteristic loads associated with a 50‐year return period be established. This is usually done by carrying out aeroelastic response simulations of the turbine. In order to estimate such rare loads, extreme loads data of adequate quantity and quality are required to facilitate robust predictions. Practitioners have expressed concerns about aspects of the load extrapolation—for instance, questions have arisen related to the minimum number of required ten‐minute turbine response simulations, about whether only a single (global) maximum load from each simulation should be saved or whether, alternatively, several time‐separated (block) maxima are preferred. Also, though turbine load types are not influenced by each wind speed between cut‐in and cut‐out to the same degree, focused simulation effort on winds that control the largest loads for each load type is not addressed. Using global and block maxima for four load measures from aeroelastic simulations on a 5 MW turbine model, we study short‐term load distributions as a function of wind speed. Block maxima for different block sizes (time separations) are tested for independence and empirical load distributions for global and block maxima are compared. We present a proposal for addressing load extrapolation that focuses on efficiency, that spells out how to employ either global or block load maxima, and that provides convergence criteria for deciding on an adequate number of simulations that must be performed before attempting long‐term load prediction using extrapolation. Copyright © 2008 John Wiley & Sons, Ltd.
Informatics approaches for identifying biologic relationships in time‐series data
Authors: McKinney Brett A. 
Published: November 2008

AbstractA vital goal of the genomic era is to identify biologic relationships between genes and gene products and to understand how these relationships influence phenotypes. Time course data contain a vast amount of causal and mechanistic information about complex systems, but experimental and informatics challenges must be overcome to produce and extract this information from biologic systems. Mathematical modeling and bioinformatics methods are being developed in anticipation of experiments involving the coordinated measurement of cellular and molecular quantities at various spatial and temporal scales. Experimental methods that probe at the nanoscale will facilitate the exploration of biologic systems at the single‐cell and single‐molecule level, but will also introduce special challenges for mathematical modeling because events at nanoscale concentrations are subject to the influence of intrinsic noise. This review addresses the progress, challenges, and frontiers in the field of time‐series informatics. The ultimate goal of time‐series informatics is to move beyond descriptive relationships and toward predictive models of emergent, or systemic, behaviors of biologic systems as a whole. Copyright © 2008 John Wiley & Sons, Inc.This article is categorized under:

Nanotechnology Approaches to Biology > Cells at the Nanoscale
Synthesis of poly(alkyl cyanoacrylate)‐based colloidal nanomedicines
Authors: Nicolas Julien , Couvreur Patrick 
Published: November 2008

AbstractNanoparticles developed from poly(alkyl cyanoacrylate) (PACA) biodegradable polymers have opened new and exciting perspectives in the field of drug delivery due to their nearly ideal characteristics as drug carriers in connection with biomedical applications. Thanks to the direct implication of organic chemistry, polymer science and physicochemistry, multiple PACA nanoparticles with different features can be obtained: nanospheres and nanocapsules (either oil‐ or water‐containing) as well as long‐circulating and ligand‐decorated nanoparticles. This review aims at emphasizing the synthetic standpoint of all these nanoparticles by describing the important aspects of alkyl cyanoacrylate chemistry as well as the experimental procedures and the different techniques involved for the preparation of the corresponding colloidal devices. Copyright © 2008 John Wiley & Sons, Inc.This article is categorized under:

Therapeutic Approaches and Drug Discovery > Emerging Technologies
Magnetic resonance susceptibility based perfusion imaging of tumors using iron oxide nanoparticles
Authors: Pathak Arvind P. 
Published: November 2008

AbstractAbundant preclinical and preliminary clinical data have convincingly supported antiangiogenic therapy as an effective strategy for the inhibition of tumor growth. This has led to an acute need for developing biological markers (biomarkers) of vascular remodeling that can be monitored in vivo, at repeated intervals in large numbers of patients with a variety of tumors in a noninvasive manner. Recently, magnetic resonance (MR) perfusion imaging with iron oxide nanoparticles has demonstrated the potential to be such a surrogate endpoint, that is, a biomarker intended to substitute for a clinical endpoint and predictive of clinical benefit. Consequently, both US Food and Drug Administration (FDA) and the National Cancer Institute (NCI) have major initiatives underway to improve the development of cancer therapies and the outcomes for cancer patients via biomarker development and evaluation. The biophysical principles, physiological relevance and range of imaging techniques underlying the success of susceptibility based contrast MR perfusion imaging with iron oxide nanoparticles as such a biomarker, are the subject of this review. Copyright © 2008 John Wiley & Sons, Inc.This article is categorized under:

Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
Pharmacokinetics of nanomaterials: an overview of carbon nanotubes, fullerenes and quantum dots
Authors: Riviere Jim E. 
Published: November 2008

AbstractA full understanding of the pharmacokinetic parameters describing nanomaterial disposition in the body would greatly facilitate development of a firm foundation upon which risk assessment could be based. This review focuses on the disposition of carbon based fullerenes and nanotubes, as well as quantum dots (QD) after parenteral administration to primarily rodents. The common theme across all particle types is that a major determinant of nanomaterial disposition is the degree of interaction with the reticuloendothelial (RE) cell system. Small water‐soluble particles evading this system may be excreted by the kidney. Larger particles and those with the proper surface charge may get targeted to RE cells in the liver, spleen and other organs. Most nanomaterial kinetics are characterized by relatively short blood half‐lives reflecting tissue extraction and not by clearance from the body. In fact, another common attribute to nanomaterial kinetics is retention of particles in the body. Finally, unlike many small organic drugs, nanomaterials may preferentially be trafficked in the body via the lymphatic system that has obvious immunological implications. Copyright © 2008 John Wiley & Sons, Inc.This article is categorized under:

Nanotechnology Approaches to Biology > Cells at the Nanoscale
Nanotechnology and orthopedics: a personal perspective
Authors: Laurencin Cato T. , Kumbar Sangamesh G. , Nukavarapu Syam Prasad 
Published: November 2008

AbstractBone is a nanocomposite material comprised of hierarchically arranged collagen fibrils, hydroxyapatite and proteoglycans in the nanometer scale. Cells are accustomed to interact with nanostructures, thus providing the cells with a natural bone‐like environment that potentially enhance bone tissue regeneration/repair. In this direction, nanotechnology provides opportunities to fabricate as well as explore novel properties and phenomena of functional materials, devices, and systems at the nanometer‐length scale. Recent studies have provided significant insights into the influence of topographical features in regulating cell behavior. Topographical features provide essential chemical and physical cues that cells can recognize and elicit desired cellular functions including preferential adhesion, migration, proliferation, and expression of specific cell phenotype to bring desired effects. The current article will address some of the nanotechnology implications in addressing issues related to orthopedic implants performance and tissue engineering approach to bone repair/regeneration. Copyright © 2008 John Wiley & Sons, Inc.This article is categorized under:

Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement
Radioactive liposomes
Authors: Phillips William Thomas , Goins Beth Ann , Bao Ande 
Published: November 2008

AbstractMany methods of labeling liposomes with both diagnostic and therapeutic radionuclides have been developed since the initial discovery of liposomes 40 years ago. Diagnostic radiolabels can be used to track nanometer‐sized liposomes in the body in a quantitative fashion. This article reviews the basic methods of single photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging and labeling of liposomes with single photon and dual photon positron emission radionuclides. Examples of the use of these diagnostic imaging agents will be shown. The ability to track the uptake of liposomes in humans and research animals on a whole body basis is providing researchers with an excellent tool for developing liposome‐based drug delivery agents. The attachment of therapeutic radionuclides to liposomes also has great promise in cancer therapy. Recent developments in the use of liposomes carrying therapeutic radionuclides for cancer therapy will also be reviewed. Many of the radiolabeling and tracking technologies developed for nanosized liposomes will also be useful for the imaging and tracking of other nanoparticles. Copyright © 2008 John Wiley & Sons, Inc.This article is categorized under:Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
The public acceptance of nanomedicine: a personal perspective
Authors: Berube David M. 
Published: November 2008

AbstractLimited understanding of a subject leads to limited perceptions, including misinformed biases and associations. In regard to the field of nanotechnology, prior biotechnologies have harmed public perception of nanotechnology through association alone. While public bias is slow to convert toward truth, it is likely that the medical applications of nanotechnology will foster a renewed interest and trust in the field through the prolonged escape from death. Copyright © 2008 John Wiley & Sons, Inc.This article is categorized under:

Toxicology and Regulatory Issues in Nanomedicine > Regulatory and Policy Issues in Nanomedicine
History of the Recurrent Laryngeal Nerve: From Galen to Lahey
Authors: Kaplan Edwin L. , Salti George I. , Roncella Manuela , Fulton Noreen , Kadowaki Mark 
Published: November 2008

AbstractDuring the second century A.D., Galen described a nerve that came from the brain on each side of the neck, went down toward the heart, and then reversed course and ascended to the larynx and caused the vocal cords to open. He called these “reversivi” (or recurrent nerves) and stated that he was the first to discover “these wonderful things.” Demonstrating before the elders of Rome, he showed that cutting the recurrent laryngeal nerve in the neck caused a live pig to stop squealing—an extraordinary feat. Because of Galen’s fame and influence, this nerve retained great importance in dissections by later anatomists and surgeons before and throughout the Renaissance. This paper documents many of these anatomical findings and highlights the importance of a careful, delicate, recurrent laryngeal nerve dissection during thyroidectomy, as popularized by Dr. Frank Lahey in 1938.
Surgical Training and Certification in the United Kingdom
Authors: Smith Andrew J. , Aggarwal Rajesh , Warren Oliver J. , Paraskeva Paraskevas 
Published: November 2008

AbstractTraining in surgical disciplines in the United Kingdom has undergone tremendous change over the past two decades. The introduction of specialist training programmes, working time directives, quality ratings and a drive toward ambulatory and minimal access surgery have led to challenges with respect to training and service commitments of healthcare professionals. A structured and centralised training system was introduced, with the concept of core followed by specialty‐specific progression, in an openly competitive manner. Within this system is the need to commence training on simulation models, and to demonstrate proficiency prior to performance of tasks on patients. This should be underpinned by objective measures such as video or dexterity‐based tools. There is also a clear need to provide personal, professional and leadership development in the form of mentorship and appraisal systems. Though continuing to develop, the profession must be mindful of current and future advances to ensure the delivery of surgeons for the future who aspire toward excellence.
Evisceration Following Abdominal Stab Wounds: Analysis of 66 Cases
Authors: da Silva Michelle , Navsaria Pradeep H. , Edu Sorin , Nicol Andrew J. 
Published: November 2008

AbstractBackgroundAbdominal stab wounds with evisceration remain an indication for emergency laparotomy. The purpose of this study was validate a policy of mandatory laparotomy for organ evisceration and a policy of selective nonoperative management with serial physical abdominal examination for omentum evisceration.MethodsThe charts of 379 patients with abdominal stab wounds who presented to our Level I trauma center over a 3‐year (January 2005 to December 2007) period were retrospectively reviewed. Altogether, 66 (17.4%) patients with evisceration were identified and included in the study. Indications for mandatory laparotomy were peritonitis, hemodynamic instability, organ evisceration, and a high spinal cord or severe head injury with an abdominal stab wound. Further data gathered included the organ eviscerated, intraabdominal organs injured, and complications. Injury severity was categorized using the revised trauma score (RTS), injury severity score (ISS), and penetrating abdominal index (PATI).ResultsOrgan and omentum evisceration occurred in 35 (53%) and 31 (47%) patients, respectively. Organs eviscerated were as follows (number of patients): small bowel in 27 (40.9%), stomach in 2 (3%), colon in 1 (1.5%), small bowel and stomach in 2 (3%), and small bowel and colon in 3 (4.5%). The mean RTS, ISS, and PATI scores were 7.71, 13.74, and 8.26, respectively. Only two (5.7%) patients with organ evisceration underwent a negative laparotomy. In total, 23 patients with omentum evisceration (21 with peritonitis, 1 with a head injury, 1 who failed abdominal observation) underwent therapeutic laparotomy. Six patients with omentum evisceration were managed successfully nonoperatively. Two patients with left thoracoabdominal omentum evisceration underwent delayed laparoscopy, which revealed a diaphragm injury in one patient. Overall, 57 (86.4%) patients with evisceration had an intraabdominal injury that required repair.ConclusionsEvisceration should continue to prompt operative intervention. An exception can be made to a select few patients with omentum evisceration with benign abdominal findings.
Randomized Controlled Trial of Roux‐en‐Y Versus Rho‐Shaped‐Roux‐en‐Y Reconstruction After Distal Gastrectomy for Gastric Cancer
Authors: Hirao Motohiro , Kurokawa Yukinori , Fujitani Kazumasa , Tsujinaka Toshimasa 
Published: November 2008

AbstractBackgroundThe main advantage of the Roux‐en‐Y (RY) operation is that it prevents bile and pancreatic juice from reaching the gastric mucosa, although the gastrojejunostomy may cause functional delayed gastric emptying (DGE), known as RY stasis syndrome. Rho‐shaped Roux‐en‐Y reconstruction (rRY), an RY reconstruction with a rho‐shaped anastomosis, is an established operation that has been found to be effective in preventing DGE.MethodsWe conducted the randomized trial of RY versus rRY reconstruction after gastric cancer resection. The primary endpoint was the frequency of DGE, and secondary endpoints were the length of postoperative hospital stay, morbidity, and nutritional status. Seventy patients were enrolled, with 35 in each group.ResultsThe incidences of postoperative mortality and morbidity did not differ significantly between the two groups. There were no significant differences in nutritional status between the two groups after discharge. Delayed gastric emptying occurred in two patients (6%) in the RY group and four patients (11%) in the rRY group (P= 0.67). Logistic regression analysis revealed that truncal vagotomy was significantly associated with DGE inhibition.ConclusionsOur findings showed that RY reconstruction after gastrectomy may be as simple and sufficient as conventional reconstruction.
Does Extralaryngeal Branching Have An Impact on the Rate of Postoperative Transient or Permanent Recurrent Laryngeal Nerve Palsy?
Authors: Casella Claudio , Pata Giacomo , Nascimbeni Riccardo , Mittempergher Francesco , Salerni Bruno 
Published: November 2008

AbstractBackgroundThis prospective study assessed the prevalence of the extralaryngeal branching of the recurrent laryngeal nerve (RLN) and its impact on the incidence of postoperative transient or permanent RLN palsy.MethodsTotal or hemithyroidectomy was performed in 115 patients, with a total of 195 RLNs displayed. The RLN extralaryngeal branches were routinely identified and preserved. The postoperative course of each patient was evaluated. Outcomes of patients with and without branching RLN were compared.ResultsIn all, 36 of 195 (18.5%) nerves showed extralaryngeal branching: 27 cases (25.5%) on the right and 9 on the left side (10.1%; p = 0.0088).Trifurcation of the RLN was identified in two dissections (1%). Bilateral bifurcations were observed in 3 of 80 (3.7%) patients. We reported four (2.1%) unilateral permanent RLN palsies, eight cases of unilateral transient nerve palsy (4.1%), and one bilateral transient RLN injury (0.6%). The comparative analysis of postoperative outcomes between branched and nonbranched RLNs revealed that the anatomical variation was more frequently associated both with unilateral permanent RLN palsy (relative risk, 13.25; 95% confidence interval, 1.42–123.73; p = 0.0204) and unilateral transient RLN palsy (relative risk, 7.36; 95% confidence interval, 1.84–29.4; p = 0.0061). The only case of bilateral transient RLN injury was associated with a nonrecurrent inferior laryngeal nerve.ConclusionsBranched RLNs represent a risk factor both for transient and permanent nerve palsy after surgery. Awareness of this anatomical variation and its routine investigation are essential during thyroid surgery to limit its relevant impact on postoperative RLN injury rate.
HSP90 is required for TAK1 stability but not for its activation in the pro‐inflammatory signaling pathway
Authors: Liu Xin Yu , Seh Cheah Chen , Cheung Peter C.F. 
Published: November 2008

MINT‐6797182:

TAK1 (uniprotkb:O43318‐2) physically interacts (MI:0218) with CDC37 (uniprotkb:Q16543) and HSP90 (uniprotkb:P07900) by anti bait coimmunoprecipitation (MI:0006)
MINT‐6797194:

TAK1 (uniprotkb:O43318‐2) physically interacts (MI:0218) with TAB1 (uniprotkb:Q15750), HSP90 (uniprotkb:P07900) and CDC37 (uniprotkb:Q16543) by anti bait coimmunoprecipitation (MI:0006)
MINT‐6797248:

TAK1 (uniprotkb:Q62073) physically interacts (MI:0218) with HSP90 (uniprotkb:P07901), CDC37 (uniprotkb:Q61081), TAB2 (uniprotkb:Q99K90) and TAB1 (uniprotkb:Q8CF89) by anti bait coimmunoprecipitation (MI:0006)
MINT‐6797232:

TAK1 (uniprotkb:O43318‐2) physically interacts (MI:0218) with HSP90 (uniprotkb:P07900) and CDC37 (uniprotkb:Q16543) by pull down (MI:0096)
MINT‐6797216:

TAK1 (uniprotkb:O43318‐2) physically interacts (MI:0218) with TAB2 (uniprotkb:Q9NYJ8), CDC37 (uniprotkb:Q16543), HSP90 (uniprotkb:P07900) and TAB1 (uniprotkb:Q15750) by anti bait coimmunoprecipitation (MI:0006)
Maternal mortality surveillance in an inland Chinese province
Authors: Gao Yu , Kildea Sue , Barclay Lesley , Hao Min , Zeng Weiyue 
Published: November 2008

AbstractObjectivesTo evaluate the Chinese maternal mortality surveillance system in an inland province and identify how it can be improved.MethodsThe review process and Chinese Maternal Deaths Reporting Form were compared with standards recommended by the UK Confidential Enquiry into Maternal and Child Health using interviews with key personnel, field observations, and reports and audits from 2003–2005.ResultsThe Chinese Maternal Deaths Reporting Form does not provide anonymity for the deceased woman, the health workers, or hospitals. The information collected is often insufficient to identify substandard care. The Review Committee was not multidisciplinary and the review was not confidential. The review findings were only available to the Review Committee.ConclusionConfidentiality should be a requirement in the maternal mortality surveillance system. The anonymous findings should be available to health workers, and be used to improve the system and inform the community about performance.