bluuebunny/crossref_metadata_2025_split huggingface dataset:
Independent female directors and integrated reporting quality: The moderating role of family ownership
Authors: Ghaleb Belal Ali , Qaderi Sumaia Ayesh , Al‐Qadasi Adel Ali 
Published: February 2024

AbstractFemale directors can affect corporate reporting through their monitoring functions. However, it is unclear whether independent female directors (IFDs) are preferred to gain a higher quality of integrated reporting (IRQ) in a context such as Malaysia, where family ownership is dominated. This study examines the relationship between IFDs and IRQ, as well as the influence of family ownership on the IFDs‐IRQ nexus. Using all Malaysian public listed companies that have voluntarily adopted IR strategy over the 2017–2021 period, the current study uses different regression models to analyze the data and provide robust results. The results find that IFDs are positively associated with IRQ. Additionally, there is a significant negative correlation between family ownership and IRQ. Furthermore, family ownership negatively moderates the positive IFDs‐IRQ relationship. The results of the subsample analysis indicate that the relationship between IFDs and IRQ is positive in companies that do not have family ownership, but negative in those that do have family ownership. This finding supports the main conclusion regarding the moderating impact of family ownership. The additional analyses support the primary findings that highlight the crucial function of IFDs in enhancing IRQ and the influence of family ownership in attenuating the favorable impact of IFDs. This research extends the existing body of literature on IR by examining the significance of female independence beyond female representation and exploring the potential impact of family ownership on this advantageous characteristic.
Aerial intelligent reflecting surface for improving the secrecy performance of wireless systems with hardware impairments
Authors: Van Vinh Nguyen 
Published: February 2024

SummaryIt has been confirmed that the aerial intelligent reflecting surface (AIRS) can dramatically improve the coverage and quality of service of wireless communication systems. This paper proposes to exploit an AIRS to enhance the physical layer security (PLS) of wireless communication systems. In particular, the AIRS flies at convenient positions for enhancing legitimate channel gain and reducing eavesdropping channel gain. Moreover, the worst‐case security is determined where the legitimate user is affected by hardware impairments (HIs) while the eavesdropper hardware is ideal (ID). The analytical expression of secrecy outage probability (SOP) of the considered systems (referred to as the AIRS‐HI systems) is derived over realistic Nakagami‐
channels recommended for application in the fifth and beyond generations (5G & B5G). To clarify the behaviors of the considered systems, the asymptotic expressions of signal‐to‐distortion‐plus‐noise ratio (SDNR) at the legitimate user, signal‐to‐noise ratio (SNR) at the eavesdropper, and SOP are also provided. Monte‐Carlo simulations are employed to confirm the accuracy of the derived theorem. Numerical results confirm that the SOP of the AIRS‐HI systems is dramatically higher than the SOP of the AIRS‐ID systems. In other words, a strong effect of HIs on the SOP of the AIRS‐HI systems is clearly indicated. Consequently, utilizing the high transmit power is not an effective solution to improve the secrecy performance of the AIRS‐HI systems. In contrast, it is essential to employ an appropriate transmit power tailored to the specific system parameters. Furthermore, the considerable advantages of incorporating AIRS are demonstrated through a comparison between the SOPs of AIRS‐HI systems and HI systems lacking AIRS. Additionally, a comprehensive examination of AIRS‐HI system behaviors is conducted by varying various system parameters, including the predefined secrecy rate, HI level, the number of reflecting elements (REs) in AIRS, WiFi network frequency, AIRS altitude, bandwidth, and channel fading order. These observations lead to the identification of numerous recommended solutions for enhancing the SOP performance of the considered AIRS‐HI systems.
Diagnosis and treatment of diabetic foot ulcer complicated with lower extremity vasculopathy: Consensus recommendation from the Chinese Medical Association (CMA), Chinese Medical Doctor Association (CMDA)
Authors: Wang Kejia , Wang Yunchuan , Shi Wenlong , Shen Kuo , Tao Ke , Ling Rui , Huang Yuesheng , Fu Xiaobing , Hu Dahai 
Published: February 2024

AbstractDiabetic foot ulcer complicated with lower extremity vasculopathy is highly prevalent, slow healing and have a poor prognosis. The final progression leads to amputation, or may even be life‐threatening, seriously affecting patients' quality of life. The treatment of lower extremity vasculopathy is the focus of clinical practice and is vital to improving the healing process of diabetic foot ulcers. Recently, a number of clinical trials on diabetic foot ulcers with lower extremity vasculopathy have been reported. A joint group of Chinese Medical Association (CMA) and Chinese Medical Doctor Association (CMDA) expert representatives reviewed and reached a consensus on the guidelines for the clinical diagnosis and treatment of this kind of disease. These guidelines are based on evidence from the literature and cover the pathogenesis of diabetic foot ulcers complicated with lower extremity vasculopathy and the application of new treatment approaches. These guidelines have been put forward to guide practitioners on the best approaches for screening, diagnosing and treating diabetic foot ulcers with lower extremity vasculopathy, with the aim of providing optimal, evidence‐based management for medical personnel working with diabetic foot wound repair and treatment.
Gene doping detection in the era of genomics
Authors: Li Ruihong , Su Peipei , Shi Yi , Shi Hui , Ding Shengqian , Su Xianbin , Chen Peijie , Wu Die 
Published: February 2024

AbstractRecent progress in gene editing has enabled development of gene therapies for many genetic diseases, but also made gene doping an emerging risk in sports and competitions. By delivery of exogenous transgenes into human body, gene doping not only challenges competition fairness but also places health risk on athletes. World Anti‐Doping Agency (WADA) has clearly inhibited the use of gene and cell doping in sports, and many techniques have been developed for gene doping detection. In this review, we will summarize the main tools for gene doping detection at present, highlight the main challenges for current tools, and elaborate future utilizations of high‐throughput sequencing for unbiased, sensitive, economic and large‐scale gene doping detections. Quantitative real‐time PCR assays are the widely used detection methods at present, which are useful for detection of known targets but are vulnerable to codon optimization at exon–exon junction sites of the transgenes. High‐throughput sequencing has become a powerful tool for various applications in life and health research, and the era of genomics has made it possible for sensitive and large‐scale gene doping detections. Non‐biased genomic profiling could efficiently detect new doping targets, and low‐input genomics amplification and long‐read third‐generation sequencing also have application potentials for more efficient and straightforward gene doping detection. By closely monitoring scientific advancements in gene editing and sport genetics, high‐throughput sequencing could play a more and more important role in gene detection and hopefully contribute to doping‐free sports in the future.
Herbivory through the lens of ecological processes across Pacific coral reefs
Authors: Kindinger Tye L. , Adam Thomas C. , Baum Julia K. , Dimoff Sean A. , Hoey Andrew S. , Williams Ivor D. 
Published: February 2024

AbstractCoral reefs are in global decline primarily due to climate change. Herbivory is often viewed as key to maintaining coral‐dominated reefs, and herbivore management is gaining traction as a possible strategy for promoting reef resilience. The functional impact of herbivorous fishes has typically been inferred from total biomass, but robust estimates of ecological processes are needed to better inform management targets. Here, we provide a framework to calculate rates of herbivory across Pacific reefs. We synthesized available observations of foraging metrics in relation to fish body size and found considerable variation, even among closely related species. We then applied these allometric functions to survey data and calculated rates of herbivory for acanthurids and scarines, which make up the vast majority of herbivorous fish biomass in the Pacific. Estimated rates of algal consumption, area scraped, and bioerosion varied across islands, with noticeable differences that may align with the relative influence of human population density among underlying herbivore functional groups. We found no evidence of compensatory relationships among herbivore processes whereby decreasing rates in one type of herbivory is offset by increasing rates in another. We observed nonlinear, positive relationships between fish biomass and rates of herbivory. Yet, for a given biomass, the corresponding rates of herbivory varied among regions, and we observed instances where islands with the greatest biomass did not also have the highest rates of herbivory. Islands with the largest size classes of herbivores did not consistently exhibit greater rates of herbivory, and we did not find a clear, consistent pattern between the number of fish species and corresponding rates of herbivore processes. Cropping Acanthurus spp. provided the greatest proportion of algal consumption at every island, yet no single species accounted for the majority of this process, whereas we identified parrotfish species that provided >75% of scraping or bioerosion at certain islands. Our results emphasize the importance of considering the species and size composition of herbivore assemblages when estimating processes, rather than relying on total biomass alone. Lastly, we highlight gaps in foraging observations and additional work needed to further broaden our ability to quantify the ecological processes of herbivores.
Mind the gap! The role of health policy capacity and vaccination acceptance in European Covid‐19 mortality differences
Authors: Farkas Beáta , Rácz Tamás Attila 
Published: February 2024

AbstractTwo years of the Covid‐19 pandemic caused significantly different death tolls in European countries. Nine of the 30 countries with the highest accumulated fatalities belong to Central and Eastern Europe, although the solidarity of the European Union (EU) provided vaccines for all member states. Using correlation and cluster analysis, this paper identifies the demographic, social, and political factors which can explain the differences. As generally accepted in the literature, the death toll is measured by the number of excess deaths. The examination separates the prevaccination and vaccination periods. While the impact of other factors is also present, vaccination coverage has a salient explanatory role in the excess deaths of the second period. The experiences of the Covid‐19 pandemic simultaneously highlight the importance and sociopolitical constraints of health policy at the European level. The analysis confirms that complementary competences between the European and national levels are adequate for the EU health policy.
Factors associated with prospective changes in weight control intentions among adolescents
Authors: Lucibello Kristen M. , Gohari Mahmood R. , Leatherdale Scott T. , Patte Karen A. 
Published: February 2024

AbstractIntroductionThe present study examined predictors of negative changes in weight control intentions from before to during the COVID‐19 pandemic among adolescents.MethodsParticipants were Canadian secondary school students enrolled in the COMPASS study and had completed self‐report surveys before (T1; 2018/2019 and/or 2019/2020 school year) and during (T2; 2020/2021 and/or 2021/2022) the COVID‐19 pandemic (N = 11,869, Mage ± SD = 13.79 years old ± 1.15, 52.89% girls, 45.30% boys, 1.81% gender diverse). Demographic, interpersonal, behavioral, and psychological predictors of weight control intention change from T1 (stay the same weight, not doing anything about weight) to T2 (lose weight, gain weight) were tested using multilevel logistic regressions.ResultsOver one‐third (37.0%) of adolescents who reported wanting to stay the same weight at T1 changed their intention to lose or gain weight at T2, as did 28.5% of adolescents who reported not wanting to do anything about their weight at T1. Changing weight control intention from “not doing anything about weight” at T1 to weight gain/loss at T2 was associated with resistance training, emotion dysregulation, bullying, social media use, and gender. Changing weight control intention from “stay the same weight” at T1 to weight gain/loss at T2 was associated with gender, perceived financial comfort, social media use, and flourishing.ConclusionsResults highlight the prevalence of maladaptive weight control intention changes among adolescents, and elucidate related behavioral, interpersonal, demographic, and psychological factors. Findings can inform targeted intervention and prevention strategies to disrupt maladaptive changes in weight control intentions among high‐risk subgroups.
Testing the reciprocal relationship between depressive symptoms and insomnia
Authors: Zhou Robert J. , Bailey Brooklynn , Strunk Daniel R. 
Published: February 2024

AbstractBackgroundAlthough the importance of sleep difficulties in emotional disorders has long been acknowledged, the nature of the potential reciprocal relationship between sleep and depressive symptoms is not yet well understood. The coronavirus disease 19 pandemic provided a unique opportunity to study the interrelation of these symptoms over a period marked by increases in sleep and psychological difficulties.MethodsUsing online data collection, we followed 1200 adults (59% male) through 1 year of the pandemic. Measures of sleep disturbance and depressive symptoms were assessed at eight time points. Factor analysis of the items from these two measures suggested separate insomnia and depressive symptom factors. A random intercept cross‐lagged panel model was used to assess within‐person relationships between factor analysis‐informed subscales of insomnia and depressive symptoms.ResultsDepressive symptoms predicted subsequent changes in insomnia symptoms; however, insomnia did not predict changes in depressive symptoms.ConclusionsOur findings suggest the impact of depressive symptoms on insomnia is evident, but the reverse is not. Implications of this finding along with the need for research addressing depressive symptoms and insomnia as treatment targets are discussed.
Non‐coding RNA LINC01010 regulates macrophage polarization and innate immune functions by modulating NFκB signaling pathway
Authors: Valverde Araceli , Naqvi Raza Ali , Naqvi Afsar R. 
Published: February 2024

AbstractInnate immune response is regulated by tissue resident or infiltrating immune cells such as macrophages (Mφ) that play critical role in tissue development, homeostasis, and repair of damaged tissue. However, the epigenetic mechanisms that regulate Mφ plasticity and innate immune functions are not well understood. Long non‐coding RNA (lncRNA) are among the most abundant class of transcriptome but their function in myeloid cell biology is less explored. In this study, we deciphered the regulatory role of previously uncharacterized lncRNAs in Mφ polarization and innate immune responses. Two lncRNAs showed notable changes in their levels during M1 and M2 Mφ differentiation. Our findings indicate that LINC01010 expression increased and AC007032 expression decreased significantly. LINC01010 exhibit myeloid cell‐specificity, while AC007032.1 is ubiquitous and expressed in both myeloid and lymphoid (T cells, B cells and NK cells) cells. Expression of these lncRNAs is dysregulated in periodontal disease (PD), a microbial biofilm‐induced immune disease, and responsive to lipopolysaccharide (LPS) from different oral and non‐oral bacteria. Knockdown of LINC01010 but not AC007032.1 reduced the surface expression of Mφ differentiation markers CD206 and CD68, and M1Mφ polarization markers MHCII and CD32. Furthermore, LINC01010 RNAi attenuated bacterial phagocytosis, antigen processing and cytokine secretion suggesting its key function in innate immunity. Mechanistically, LINC01010 knockdown Mφ treated with Escherichia coli LPS exhibit significantly reduced expression of multiple nuclear factor kappa B pathway genes. Together, our data highlight functional role of a PD‐associated lncRNA LINC01010 in shaping macrophage differentiation, polarization, and innate immune activation.
Classic human astrovirus 4, 8, MLB‐3, and likely new genotype 5 sublineage in stool samples of children in Nigeria
Authors: Ijeomah Ifeorah M. , Temitope Faleye O. C. , Lander De Coninck , Sheriff Agbaje T. , Uwem George E. , Bernard Onoja A. , Oluseyi Olayinka A. , Elijah Oni I. , Toluwani Ajileye G. , Arthur Oragwa O. , Toluwanimi Akinleye E. , Bolutife Popoola O. , Damilola Osasona G. , Titilola Olayinka O. , Oluwadamilola George A. , Muhammad Ahmed I. , Omotosho Komolafe I. , Johnson Adeniji A. , Jelle Matthijnssens , Olubusuyi Adewumi M. 
Published: February 2024

AbstractHuman astrovirus (HAstV) is a nonenveloped RNA virus and has been implicated in acute gastroenteritis among children and elderly. However, there exists a substantial dearth of information on HAstV strains circulating in Nigeria. Viral‐like particles were purified from archived 254 stool samples of children with acute flaccid paralysis between January and December 2020 from five states in Nigeria, using the NetoVIR protocol. Extracted viral RNA and DNA were subjected to a reverse transcription step and subsequent random polymerase chain reaction amplification. Library preparation and Illumina sequencing were performed. Using the virome paired‐end reads pipeline, raw reads were processed into genomic contigs. Phylogenetic and pairwise identity analysis of the recovered HAstV genomes was performed. Six near‐complete genome sequences of HAstV were identified and classified as HAstV4 (n = 1), HAstV5 (n = 1), HAstV8 (n = 1), and MLB‐3 (n = 3). The HAstV5 belonged to a yet unclassified sublineage, which we tentatively named HAstV‐5d. Phylogenetic analysis of open reading frames 1a, 1b, and 2 suggested recombination events inside the MAstV1 species. Furthermore, phylogenetic analysis implied a geographic linkage between the HAstV5 strain from this study with two strains from Cameroon across all the genomic regions. We report for the first time the circulation of HAstV genotypes 4, 8, and MLB‐3 in Nigeria and present data suggestive for the existence of a new sublineage of HAstV5. To further understand the burden, diversity, and evolution of HAstV, increased research interest as well as robust HAstV surveillance in Nigeria is essential.
Analytical evaluation of the automated genotyping system (GenPlex) compared to a traditional real‐time PCR assay for the detection of high‐risk human papillomaviruses
Authors: Zhang Lijuan , Ju Yan , Hu Haixu , Ma Chunhui , Yu Yanju , Huang Yan , Gong Lili , Zhao Wei , Liu Yujia , Liu Yi , Bian Lihong 
Published: February 2024

AbstractThe detection of high‐risk human papillomaviruses (HPVs) is crucial for early screening and preventing cervical cancer. However, the substantial workload in high‐level hospitals or the limited resources in primary‐level hospitals hinder widespread testing. To address this issue, we explored a sample‐to‐answer genotyping system and assessed its performance by comparing it with the traditional real‐time polymerase chain reaction (PCR) method conducted manually. Samples randomly selected from those undergoing routine real‐time PCR detection were re‐analyzed using the fully automatic GenPlex® system. This system identifies 24 types of HPV through a combination of ordinary PCR and microarray‐based reverse hybridization. Inconsistent results were confirmed by repeated testing with both methods, and the κ concordance test was employed to evaluate differences between the two methods. A total of 365 samples were randomly selected from 7259 women. According to real‐time PCR results, 76 were high‐risk HPV negative, and 289 were positive. The GenPlex® system achieved a κ value greater than 0.9 (ranging from 0.920 to 1.000, p < 0.0001) for 14 types of high‐risk HPV, except HPV 51 (κ = 0.697, p < 0.0001). However, the inconsistent results in high‐risk HPV 51 were revealed to be false positive in real‐time PCR by other method. When counting by samples without discriminating the high‐risk HPV type, the results of both methods were entirely consistent (κ = 1.000, p < 0.0001). Notably, the GenPlex® system identified more positive cases, with 73 having an HPV type not covered by real‐time PCR, and 20 potentially due to low DNA concentration undetectable by the latter. Compared with the routinely used real‐time PCR assay, the GenPlex® system demonstrated high consistency. Importantly, the system's advantages in automatic operation and a sealed lab‐on‐chip format respectively reduce manual work and prevent aerosol pollution. For widespread use of GenPlex® system, formal clinical validation following international criteria should be warranted.
STEMming the tide: New perspectives on careers and turnover
Authors: Kiazad Kohyar , Restubog Simon Lloyd D. , Hom Peter W. , Capezio Alessandra , Holtom Brooks , Lee Thomas 
Published: February 2024

SummaryThe question of why so many people leave science, technology, engineering and mathematics (STEM) jobs continues to echo through social science research and Government policy. This is not surprising given the considerable investments into uptake and quality of STEM education and that STEM workers have a pivotal role to play in addressing current and future grand challenges. Yet, too many individuals with tertiary degrees in STEM—disproportionately women, racial minorities, and the underprivileged—leave or pursue careers in non‐STEM fields. While demand for employment in STEM continues to grow, such persistent STEM defections present a significant challenge. We offer an integrative special issue of eight empirical articles capturing current thinking and evidence on employee retention and turnover, both within and beyond the realm of STEM. Our thematic analysis of the articles reveals overarching themes around the fundamental question of why people choose to stay in their jobs and why they leave. From this, we provide a future research agenda recognizing the myriad work and nonwork factors influencing the desire and ability to stay in one's chosen profession, particularly in critical sectors where gender and minority attrition rates prevail.