bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness analysis of dapagliflozin for people with chronic kidney disease in Malaysia
Authors: Lim Soo Kun , Lee Shaun Wen Huey 
Published: March 2024

Introduction
Chronic kidney disease (CKD) is a global health concern which results in significant economic burden. Despite this, treatment options are limited. Recently, dapagliflozin has been reported have benefits in people with CKD. This study aimed to evaluate the cost–effectiveness of dapagliflozin as an add-on to standard of care (SoC) in people with CKD in Malaysia.

Methods
A Markov model was adapted to estimate the economic and clinical benefits of dapagliflozin in people with Stage 2 to 5 CKD. The cost-effectiveness was performed based upon data from the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) trial supplemented with local costs and utility data whenever possible.

Results
In Malaysia, dapagliflozin in combination with SoC was the dominant intervention compared to SoC alone (RM 81,814 versus RM 85,464; USD19,762 vs USD20,644). Adding dapagliflozin to SoC in people with CKD increased life expectancy by 0.46 years and increased quality-adjusted life years (QALY) by 0.41 in comparison with SoC alone (10.01 vs. 9.55 years, 8.76 vs. 8.35 QALYs). This translates to a saving of RM8,894 (USD2,148) with every QALY gained. The benefits were due to the delay in CKD progression, resulting in lower costs of dialysis and renal transplantation. Results were robust to variations in assumptions over disease management costs as well as subgroup of population that would be treated and below the accepted willingness-to-pay thresholds of RM 46,000/QALY.

Conclusion
The use of dapagliflozin was projected to improved life expectancy and quality of life among people with CKD, with a saving RM8,894 (USD2,148) for every quality-adjusted life-year gained and RM7,898 (USD1,908) saving for every life year gained.
Impact of prenatal maternal dietary exclusion on childhood obesity and overweight risk
Authors: Horne Brenton , Kabir Enamul , Alam Khorshed 
Published: March 2024

Background
Child birthweight is a measure of fetal nutrition that is primarily determined by prenatal maternal (PM) diet. Child birthweight and child obesity/overweight risk are well established to be linked. Nevertheless, no studies have investigated the impact of PM dietary exclusion on child obesity/overweight risk or body mass index z-score (BMIz).

Objectives
The study aimed to determine whether PM dietary exclusion affected the child’s BMIz, obesity/overweight risk, whether child birthweight serves as a mediator of this, and whether PM use of dietary supplements can protect against this.

Methods
Waves within the years 2004–2019 from the Longitudinal Study of Australian Children, a population-based cohort study, were analyzed. The participants were aged 0 to 15 years during these waves of the study. Analysis was conducted using logistic and linear models. A total of 5,107 participants were involved in the first wave of the study.

Results
The PM exclusion of fish was associated with a higher risk of being underweight at age 14 or 15 years and mild-to-moderate obesity at age 6 or 7 years. The PM exclusion of egg was associated with a higher risk of being overweight at age 14 or 15 years. The exclusion of dairy was associated with more mixed effects. Mediation effects did not reach statistical significance. Moderation effects involving PM dietary supplement use, when they did occur, were associated with higher child BMIz and usually a higher risk of obesity/overweight.

Conclusions
Fish and eggs are likely important parts of PM diets for preventing childhood obesity and overweight. Further studies will be needed to determine reasons for this and the apparent adverse effects of dietary supplements on overweight/obesity risk.
Associations between adiposity measures and depression and well-being scores: A cross-sectional analysis of middle- to older-aged adults
Authors: Lonergan Caoimhe , Millar Seán R. , Kabir Zubair 
Published: March 2024

Background
Obesity and mental health are significant global health concerns. Evidence has linked increased adiposity with depression and well-being; however, there is limited documented evidence in Ireland. Research also suggests lifestyle factors and disease conditions to be related to mental health. These may modulate relationships between adiposity and depression and well-being.

Methods
This was a cross-sectional study of 1,821 men and women aged 46–73 years, randomly selected from a large primary care centre. Depression and well-being were assessed using the 20-item Centre for Epidemiologic Studies Depression Scale (CES-D) and the World Health Organization-Five (WHO-5) Well-Being Index. Linear regression analyses were performed to examine relationships between mental health scores (dependent variable) and adiposity (independent variable) defined using body mass index (BMI) and waist-height ratio while adjusting for demographic characteristics, lifestyle factors and disease conditions.

Results
BMI and waist-height ratio had a significant positive association with depression scores and a significant inverse association with well-being scores in males and females. These associations were maintained following adjustment for demographic variables and lifestyle factors. In final models where disease conditions were adjusted for, BMI (β = 0.743, p < .001) and waist-height ratio (β = 0.719, p < .001) associations with the CES-D score remained significant. In stratified analyses, relationships between measures of adiposity and depression were found to be stronger in females (BMI: β = 0.806, p = .007; waist-height ratio: β = 0.768, p = .01) than males (BMI: β = 0.573, p = .049; waist-height ratio: β = 0.593, p = .044) but no effect modification was identified.

Conclusions
These findings suggest that increased adiposity is significantly associated with poorer mental health, independent of lifestyle factors and disease conditions. Targeted interventions for reducing depression should include better population-level weight management measures.
tratamiento de la mitología en los escolios de Aristófanes
Authors: BILBAO RUIZ JAVIER 
Published: March 2024

Este artículo estudia el tratamiento de la mitología en los escolios de Aristófanes. En primer lugar, se presta atención al papel que juega la mitología en Aristófanes, dado que los escoliastas siempre van a aludir a esa disciplina para explicar las comedias del cómico ateniense. A continuación, se estudia la terminología que usan los escoliastas para referirse a las cuestiones míticas y, luego, se presta atención al valor real que aportan los escolios para el conocimiento de la mitología. Para terminar, se describen los contextos en los que se aglutina la exégesis mitológica, prestando atención a la racionalización de los mitos. Los escoliastas se sienten cómodos explicando cuestiones míticas dentro de los parámetros de un sistema en el que la explicación racional del mito está bien integrada.
Palabras clave: Mito; mitología; escolios; progymnasmata; Aristófanes
Pollen grain bioassay for environmental contamination biomonitoring
Authors: Paradiž Jasna , Lovka Milan 
Published: March 2024

Pollen grain bioassay near some highways was performed in 45 plant species for identification of environmental genotoxic impact on naturally growing plants due to environmental traffic contaminants. A relationship between the duration of heavy traffic on particular road sections and the degree of develop­ mental and morphological changes of pollen grains was indicated.
Increased fre­ quency of pollen deformation after more than 20 years of traffic influence was established, indicating the applicability of pollen grain bioassay for genotoxic risk assessment of chronic low level contamination impact in natural habitats.
mTORC1 hyperactivation and resultant suppression of macroautophagy contribute to the induction of cardiomyocyte necroptosis by catecholamine surges
Authors: Cai Mingqi , Wu Penglong , Ni Wei , Huang Dong , Wang Xuejun 
Published: March 2024

AbstractPrevious studies revealed a controversial role of mechanistic target of rapamycin complex 1 (mTORC1) and mTORC1‐regulated macroautophagy in isoproterenol (ISO)‐induced cardiac injury. Here we investigated the role of mTORC1 and potential underlying mechanisms in ISO‐induced cardiomyocyte necrosis. Two consecutive daily injections of ISO (85 mg/kg, s.c.) or vehicle control (CTL) were administered to C57BL/6J mice with or without rapamycin (RAP, 5 mg/kg, i.p.) pretreatment. Western blot analyses showed that myocardial mTORC1 signaling and the RIPK1–RIPK3–MLKL necroptotic pathway were activated, mRNA expression analyses revealed downregulation of representative TFEB target genes, and Evan's blue dye uptake assays detected increased cardiomyocyte necrosis in ISO‐treated mice. However, RAP pretreatment prevented or significantly attenuated the ISO‐induced cardiomyocyte necrosis, myocardial inflammation, downregulation of TFEB target genes, and activation of the RIPK1–RIPK3–MLKL pathway. LC3‐II flux assays confirmed the impairment of myocardial autophagic flux in the ISO‐treated mice. In cultured neonatal rat cardiomyocytes, mTORC1 signaling was also activated by ISO, and inhibition of mTORC1 by RAP attenuated ISO‐induced cytotoxicity. These findings suggest that mTORC1 hyperactivation and resultant suppression of macroautophagy play a major role in the induction of cardiomyocyte necroptosis by catecholamine surges, identifying mTORC1 inhibition as a potential strategy to treat heart diseases with catecholamine surges.
Evaluation of influence ofButea monospermafloral extract on inflammatory biomarkers
Authors: Zahra Nureen , Mazhar Aansa , Zahid Beenish , Naeem Muhammad Ahsan , Sarwar Abid , Aziz Tariq , Alharbi Metab , Albekairi Thamer H. , Alasmari Abdullah F. 
Published: March 2024

AbstractButea monospermais a deciduous tree, widely distributed throughout India, Burma, and Ceylon. The present study was intended to investigate the anti-inflammatory effects ofButea monospermaon the induced inflammatory model by evaluating pro-inflammatory biomarkers and their computational analysis. The anti-inflammatory activity may be attributed to the phyto-constituents for inhibitory effects on the two pro-inflammatory mediators (IL-8 and TNF-α). For this purpose, rats (n= 48) were equally divided in each group, i.e., 8 each in the negative and positive control and 32 in the experimental group with 8 rats for each dose, i.e., 50, 100, 200, and 400 mg/kg. TNF-α and IL-8 were tested by serum enzyme-linked immunosorbent assay (ELISA). The ELISA results showed 400 mg/kg dose as the potent anti-inflammatory. The binding sites of target proteins (TNF-α and IL-8) were docked with the active compounds (butrin and butein) ofButea monosperma. The butrin (target: TNF-α) and butein (target: IL-8) showed −8.4 and −6.0 kcal/mol binding energies, respectively, compared to the (diclofenac) standard drug with −6.8 kcal/mol binding energy. Hence, we concluded thatButea monospermacan be subjected to as a useful anti-inflammatory drug.
Performance evaluation of grouted porous asphalt concrete
Authors: Abdulsahib Iftikhar , Hilal Miami M. , Fattah Mohammed Y. , Dulaimi Anmar 
Published: March 2024

Abstract
Semiflexible pavement (SFP) is considered a composite mixture, as it consists mainly of a porous asphalt mixture with high air voids grouted with highly flowed cementitious grout. Numerous benefits have been attributed to this technology, including exceptional slip resistance, a high static bearing capacity, and rutting resistance. In this study, two different types of semiflexible paving mix were produced by using two different types of grouting materials (GMs). There is a discrepancy between the compressive strengths of the two GMs used, as the compressive strength of the first mixture, which consisted of 96% cement and 4% silica fume (SF), was approximately twice the compressive strength of the second mixture, which consisted of 75% cement and 25% sand. The mechanical and durable properties of the two SFPs were studied, in addition to the effect of variation in the compressive strengths of the two GMs and their effect on the final performance of the pavement. The results of Marshall and rutting tests show that the SFP material exhibits good high-temperature stability. The effect of the variation in the compressive strength of the two mixtures was evident in the results of the tests compared with the sand mixture at a strength of 20.8 MPa, the SF at a strength of 48.1 MPa witnessed a 39.54% increase in the Marshall stability at 28-day curing age. Also, the composite material (CM) showed better rutting performance than traditional asphalt mixtures, which did not exceed 2 mm. The results of the indirect tensile strength (ITS) test showed a discrepancy between the two types of CM, as the ITS value of the grouting material of SF (GMSF) mixture increased by 14.91% compared with the grouting material of sand (GMSN) for the curing age of 28 days for unconditioned samples and by 20.22% for the conditioned samples for the same curing age, while the durability of two types of CM was measured by Cantabro abrasion loss and tensile strength ratio. The results were acceptable and within the specification limits. With a variation for the two types of CM, the GMSF mixture showed an increase in the value of Cantabro loss by 11.52% over the GMSN mixture for ageing samples and 6.59% for non-aging samples of 28 days of curing age.
Appraisal of current technologies for the study of genetic alterations in hematologic malignancies with a focus on chromosome analysis and structural variants
Authors: Salaverria Itziar , Siebert Reiner , Mrózek Krzysztof 
Published: March 2024

Abstract
During the last five decades, chromosome analysis identified recurring translocations and inversions in leukemias and lymphomas, which led to cloning of genes at the breakpoints that contribute to oncogenesis. Such molecular cytogenetic methods as fluorescence in situ hybridization (FISH), copy number (CN) arrays or optical genome mapping (OGM) have augmented standard chromosome analysis. The use of both cytogenetic and molecular methods, such as reverse transcription-polymerase chain reaction (RT-PCR) and next generation sequencing (NGS), including whole-genome sequencing (WGS), discloses alterations that not only delineate separate WHO disease entities but also constitute independent prognostic factors, whose use in the clinic improves management of patients with hematologic neoplasms.
Genetic alterations in chronic lymphocytic leukemia and plasma cell neoplasms – a practical guide to WHO HAEM5
Authors: Tausch Eugen , López Cristina , Stilgenbauer Stephan , Siebert Reiner 
Published: March 2024

Abstract
The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours (WHO-HAEM5) provides a revised classification of lymphoid malignancies including chronic lymphocytic leukemia (CLL) and plasma cell myeloma/multiple myeloma (PCM/MM). For both diseases the descriptions of precursor states such as monoclonal B-cell lymphocytosis and monoclonal gammopathy of uncertain significance (MGUS) have been updated including a better risk stratification model. New insights on mutational landscapes and branching evolutionary pattern were embedded as diagnostic and prognostic factors, accompanied by a revised structure for the chapter of plasma cell neoplasms. Thus, the WHO-HAEM5 leads to practical improvements of biological and clinical relevance for pathologists, clinicians, geneticists and scientists in the field of lymphoid malignancies. The present review gives an overview on the landscape of genetic alterations in CLL and plasma cell neoplasms with a focus on their impact on classification and treatment.
Overview on WHO-HAEM5 and the diagnostic relevance of genetic alterations for the classification
Authors: Haferlach Claudia , Ott German , Hörst Katharina , Kühn Constanze , Haferlach Torsten , Siebert Reiner 
Published: March 2024

Abstract
The landscape of haematological malignancies is constantly evolving, driven by advances in our understanding of their genetic basis. This has cumulated within the 5th Edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours published in short form in 2022 [1, 2] and being available in full length both as “Blue Book” (in print expected early 2024) as well as web-based classification (see: https://tumourclassification.iarc.who.int/welcome/). Similarly, the importance of genetic alterations for the classification is highlighted in other classification systems related to haematologic neoplasms [3–5]. In this special issue of the Medizinische Genetik, we present a comprehensive overview of the genetic alterations contributing to the classification of haematolymphoid neoplasms in the 5th Edition of the WHO classification (WHO-HAEM5) and its diagnostic relevance in the context of various haematological malignancies.
Multifunctional all-dielectric quarter-wave plate metasurfaces for generating focused vector beams of Bell-like states
Authors: Cui Guosen , Gu Manna , Cheng Chen , Zhang Ziheng , Zhou Yuxiang , Dong Qingrui , Gao Song , Choi Duk-Yong , Cheng Chuanfu , Liu Chunxiang 
Published: March 2024

Abstract
The generation of vector beams using metasurfaces is crucial for the manipulation of light fields and has significant application potential, ranging from classical physics to quantum science. This paper introduces a novel dielectric metasurface composed of quarter-wave plate (QWP) meta-atoms, known as a QWP metasurface, designed to generate focused vector beams (VBs) of Bell-like states under right circularly polarized illumination. The propagation phase imparted on both the co- and cross-polarized components of the output field constructs hyperbolic and helical phase profiles with topological charge l

p
, whereas the Pancharatnam–Berry (PB) phase acts only on the cross-polarized component to construct another helical phase profile with topological charge l

g
. Thus, the co- and cross-polarized components form two orthogonal vector vortex (VV) modes with topological charges l

p
and l

p
+ l

g
, respectively. When the parameter conditions are satisfied by matching the incident polarization chirality σ and topological charges l

p
and l

g
, the focused VBs of Bell-like states are generated by simultaneously manipulating the two VV modes, in contrast to existing QWP metasurfaces. The polarization states of the generated VBs are manipulated using the initial orientation angle θ
0 of the meta-atom. Overall, this research provides an innovative strategy for metasurface design, enhancing the functionality of metasurface devices for a broader range of application scenarios.
Agensdemotion und gesprochene Wissenschaftssprache: Eine Studie zu (un-)persönlicher Selbstreferenz in erstsprachigen und fremdsprachigen Fachvorträgen
Authors: Matthies Jochen 
Published: March 2024

Abstract
This quantitative study examines self-reference in conference presentations by L1 and Polish L2 speakers of German. It analyses which linguistic structures are used to express different types of self-reference. Usage of the first person is shown to be lower than in spontaneous oral conversation, but considerably higher than in written academic texts. Moreover, speakers use a variety of types of agent demotion (such as the passive voice) that are also common in written academic language. The data shows that the L1 speakers use more first person pronouns than the L2 speakers. This may be due to cultural differences between German and Polish academia. An alternative explanation is that L2 speakers have a stronger tendency to rely on written manuscripts for their presentations. Distinguishing between discourse comments, methodical comments and eristic comments, the study also shows that different types of self-reference correlate with different linguistic structures.
Investigations on the enhanced anti-microbial activity of one step synthesized ZnO, WO3, and rGO nano particles and fabrication of rGO nano electrode for EMG biomedical application
Authors: Subramaniam Kavitha , Mohan Konganapuram S. , Bhoopesh Rajappan K. , Gunavathy Kugalur V. 
Published: March 2024

Abstract
The proposed study aims to synthesize ZnO, WO3, and rGO nano particles (NPs) using simple and effective chemical reduction technique and to investigate its biomedical applications. According to the XRD results, synthesized NPs had hexagonal, monoclinic, and cubic crystal forms. The FESEM micro image shows sheet-like structure for rGO NPs, an algal crystal structure for ZnO, and a bulk cluster formation for WO3 NPs. The value of band gap was found to be 5.75, 5.37 and 3.01 eV for ZnO, WO3, and rGO NPs respectively. The presence of diverse functional groups in the produced NPs was verified using Fourier-transform infrared spectroscopy. Investigations against different microorganisms indicated an augmentation in the antibacterial activity for ZnO and WO3 NPs. Electrodes coated with rGO NP were made and discovered to be effective in collecting human biomedical data more effectively. The performance of rGO NP coated electrodes was compared using a development board for electromyography analysis along with an android application for monitoring purposes. The quality of the signal, the ratio between the signal and the background noise, as well as the level of impedance between the electrode and the skin was observed to be better than conventional electrodes.
Interactive AI Virtual Teaching Resource Intelligent Recommendation Algorithm Based on Similarity Measurement on the Internet of Things Platform
Authors: Fan Ying 
Published: March 2024

Abstract
To tackle the issues of low recommender system correctness and the long time of recommendation in the traditional intelligent recommendation algorithm of interactive artificial intelligence (AI) virtual teaching resources, a similarity measurement-based intelligent recommendation algorithm of interactive AI virtual teaching resources is proposed. According to the contact frequency of adjacent learners, the behavior patterns of learners are mined, and the user characteristics are selected on the basis of the mutual information feature selection method. In the context of the category attribute matrix and learner category attribute scoring matrix of interactive AI virtual teaching resources, the user interest matrix is constructed by the Relevance Feedback based on Inverse Learning Function (RF-ILF) method. The user similarity is calculated and the neighbor set is found in the similar user clusters after clustering. According to the results of the simulation, the suggested algorithm is more efficient and provides more accurate recommendations when recommending interactive AI virtual teaching resources.
The Study of The Impact of Onshore Harbor Layout on Coastal Sedimentation and Erosion at Pekalongan Beach
Authors: Fattah Zihad Al , Sangkawati Sri , Suharyanto Suharyanto 
Published: March 2024

Pekalongan City is an area that frequently experiences floods. In response, the government has launched a flood management program for the Pekalongan area, which includes the relocation of the National Fishery Harbor Pekalongan. The construction of the Pekalongan Onshore Harbor will change marine hydrodynamics, current, waves and sediments. To address these issues, it is necessary to conduct a study of these changes. According to the modeling results, the maximum current speed in the harbor pool ranges from 0 to 0.28 m/s, while the maximum wave height in the harbor pool falls within the range of 0 to 0.40 meters. The bed level change at the end of modeling in the harbor pool is 0.108 mm. Notably, the construction of the Pekalongan Onshore Harbor, as per the planned layout, induces hydrodynamic changes. An indicator of a hydrodynamics change is the alteration in currents at T4 and T5 in each model. In the proposed harbor layout, T4 and T5 exhibit a decrease in current speed, while the wave height remains relatively consistent. This change reduces erosion at T5 and even leads to sedimentation at T4 within the planned harbor layout.