bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor length as a prognostic factor in esophageal malignancy: Univariate and multivariate survival analyses
Authors: Griffiths Ewen A. , Brummell Zoe , Gorthi Ganesh , Pritchard Susan A. , Welch Ian McL 
Published: February 2006

AbstractBackground and ObjectivesGastrointestinal specialists generally feel that long esophageal tumors carry a worse prognosis and are likely to be more advanced than shorter lesions. Our aim was to investigate the relationship between histologically determined tumor length and aspects of tumor pathology and survival for patients with resected esophageal malignancy.MethodsThree hundred and nine patients who underwent esophageal resection with curative intent in our unit between 1994 and 2003 were retrospectively analyzed. Pathological details such as TNM stage, differentiation, completeness of surgical resection, and overall stage were collected. Survival data were obtained for each patient and univariate and multivariate analyses were performed. Overall survival was used as the primary endpoint.ResultsThere were 225 adenocarcinomas, 72 squamous cell carcinomas, and 12 other tumor types with a median tumor length of 3.5 cm (range 0.5–14 cm). Tumor length greater than 3.5 cm was associated with increasing T stage (P = 0.0001), N stage (P = 0.032), overall stage (P = 0.003), and involvement of the longitudinal resection margins (P = 0.02). Univariate analysis found tumor length greater than 3.5 cm was associated with worse overall survival compared with shorter tumors (P = 0.0002). Tumor length remained a significant prognostic factor on multivariate analysis (P = 0.04). Other prognostic factors on multivariate analysis were age, tumor differentiation, nodal involvement, and resection margin status.ConclusionTumor length greater than 3.5 cm (as determined histologically) is associated with worse disease stage and poor overall patient survival. If preoperative endoscopic tumor length bears a similar relationship, this could assist in patient selection for appropriate treatments. J. Surg. Oncol. 2006;93: 258–267. © 2006 Wiley‐Liss, Inc.
Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression
Authors: Kim Se‐Heon , Cho Nam Hoon , Kim Kyubo , Lee Jin Seok , Koo Bon Seok , Kim Jeong Hong , Chang Jung Hyun , Choi Eun Chang 
Published: February 2006

AbstractBackground and ObjectivesIn oral tongue cancer, the degree of tumor invasion has a significant effect on the prognosis. We hypothesized that the destruction of extracelluar matrix and neovascularization are related to tumor infiltration mechanism. By studying the tissues of early stage oral tongue cancer patients, we are intending to clarify the invasion‐related factors.Materials and MethodsTo demonstrate the invasion process in early T‐stage oral tongue cancer, the expressions of extracellular matrix destruction‐related molecules (MMP‐2, MMP‐9) and neovascularization‐related molecule (VEGF) were observed by immunohistochemical study. Also, staining of CD31 was done for quantification of neovascularization. We analyzed relationship between expression of each substances and tumor invasion depth, tumor free survival rates, and cervical lymph node metastasis rate.ResultsThe expression rates of MMP‐2, MMP‐9, VEGF in 38 early oral cancer patients were 52.6%, 78.9%, and 52.6%, respectively. Significant correlation was found between the VEGF expression and microvessel density showed by CD31 immunohistochemical staining (P < 0.001). VEGF expressions were significantly related with tumor invasion depth (P = 0.002). The tumor‐free survival rate of those patients with VEGF‐positive tumors was significantly poorer than in those with VEGF‐negative tumors (P = 0.019).ConclusionsThese results indicate that VEGF is a useful marker for predicting the tumor invasion in patients with early tongue cancer. J. Surg. Oncol. 2006;93: 330–337. © 2006 Wiley‐Liss, Inc.
Surgical treatment of patients with initially inoperable and/or metastatic gastrointestinal stromal tumors (GIST) during therapy with imatinib mesylate
Authors: Rutkowski Piotr , Nowecki Zbigniew , Nyckowski Pawel , Dziewirski Wirginiusz , Grzesiakowska Urszula , Nasierowska‐Guttmejer Anna , Krawczyk Marek , Ruka Wlodzimierz 
Published: February 2006

AbstractBackgroundThe aim of the study was to analyze the surgical possibilities of unresectable and/or metastatic GIST CD117(+) patients during imatinib treatment.MethodsWe analyzed the results of surgery in 141 patients treated with imatinib for initially inoperable and/or metastatic GIST CD117(+). Median follow‐up time was 12 months (range: 3–26).ResultsSurgery was performed as subsequent treatment in 24 patients (Group I, 17%) for resection of residual disease after complete/partial response and lack of further response to imatinib and as salvage therapy in eight patients (Group II, 6%), who progressed on initially successful imatinib therapy. In Group I, the viable GIST cells were not detected histologically in only three resection specimens. The first five patients in Group I did not receive imatinib further and we observed four recurrences. In next 19 patients, continuing imatinib after surgery, we observed only one relapse. In Group II, we continued imatinib therapy after high‐risk surgical procedures, but in five patients we observed subsequent progression.ConclusionsSurgical removal of residual disease during imatinib treatment may allow for complete remission in selected GIST patients after response to therapy, theoretically prolonging durable remission, but it is necessary to continue imatinib for its maintenance. J. Surg. Oncol. 2006;93:304–311. © 2006 Wiley‐Liss, Inc.
Modified intrapleural cisplatin treatment for lung cancer with positive pleural lavage cytology or malignant effusion
Authors: Muraoka Masashi , Oka Tadayuki , Akamine Shinji , Tagawa Tsutomu , Morinaga Masafumi , Inoue Masao , Yamayoshi Takatomo , Hashizume Satoshi , Matsumoto Keitaro , Hayashi Tomayoshi , Nagayasu Takeshi 
Published: February 2006

AbstractObjectivesWe evaluate the efficacy and safety of the modified intrapleural cisplatin treatment for lung cancer patients with positive pleural lavage cytology or malignant effusion.MethodsThe treatment was performed for seven patients with malignant effusion and 18 patents with positive pleural lavage cytology. After pulmonary resection, the pleural cavity was filled with cisplatin with a normal saline solution for 30 min. Complications and survival of the patients were evaluated.ResultsThe chest tube duration were significantly prolonged in the treatment (CDDP) group (5.7 ± 3.6 vs. 2.8 ± 2.6 days). We had one operative death that developed a bronchial fistula; however, the other complications were not severe. The mortality rate was 4% and the morbidity rate was 60%. We experienced two carcinomatous pleuritis in the CDDP group. The median survival time of the CDDP group was 47.0 ± 11.1 months and the 3‐ and 5‐year survival rate was 52.6% and 11.3%, respectively.ConclusionsWe were able to perform this treatment for these advanced lung cancer patients, which had the preventive effect of carcinomatous pleuritis. This therapy shows the possibility of a treatment that might lead to an improvement in the prognosis of these patients, without causing severe complications. J. Surg. Oncol. 2006;93: 323–329. © 2006 Wiley‐Liss, Inc.
Feasibility of bisegmentectomy 7–8 is independent of the presence of a large inferior right hepatic vein
Authors: Machado Marcel Autran C. , Herman Paulo , Makdissi Fabio F. , Figueira Estela R.R. , Bacchella Telesforo , Machado Marcel C.C. 
Published: February 2006

AbstractBackgroundRight superior liver resection or bisegmentectomy 7–8 is defined as the anatomical removal of segments 7 and 8 of the liver. According to recent reports, this type of resection requires the presence of a large accessory right inferior hepatic vein to drain the remaining segment 6. However, anatomic studies have shown that segment 6 has multiple veins presenting several anastomosis with the surrounding hepatic veins. Therefore, the maintenance of the veins from segment 5 that ultimately drain into the middle hepatic vein can be enough to assure venous drainage of both segments.MethodsDescribe an alternative technique for bisegmentectomy 7–8 using intrahepatic glissonian access in patients with absence of a large inferior right hepatic vein.ResultsThe technique was successfully performed in four consecutive patients without immediate or long‐term venous or venous related complications.ConclusionsBisegmentectomy 7–8 may increase resectability rate in patients with bilateral lesions and may also enhance the opportunity to perform repeated resections in cases of tumor recurrence. Our study confirms the anatomical assumption that bisegmentectomy 7–8 did not result in segmental outflow block even in the absence of a thick inferior right hepatic vein and therefore should be performed more often than reported so far. The absence of this vein should not be a straightforward indication for right hepatectomy in cases where a liver‐sparing procedure such as bisegmentectomy 7–8 can be safely employed. J. Surg. Oncol. 2006;93: 338–342. © 2006 Wiley‐Liss, Inc.
No association of primary adenocarcinomas of the small bowel with Epstein‐Barr virus infection
Authors: von Rahden Burkhard H.A. , Langner Cord , Brücher Björn L.D.M. , Stein Hubert J. , Sarbia Mario 
Published: February 2006

AbstractEpstein‐Barr Virus (EBV) infection is considered to play an etiologic role in human malignancies, including a subset of gastric and cardiac cancers. Adenocarcinomas of the small bowel comprise a very rare entity, with little knowledge about molecular properties and etiological aspects. We have investigated the prevalence of EBER expression (EBV‐encoded small RNAs) in a series of small bowel adenocarcinomas (n = 56) utilizing RNA in situ hybridization (EBER‐RISH). The patients had undergone primary surgical resection at either the Technical University of Munich or at the University of Graz. A surgical series of 82 primary resected gastric (n = 36) or cardiac (n = 46) adenocarcinomas (TU Munich) was used as control group. None of the 56 small bowel carcinomas exhibited EBER expression whereas in the control group the rate of EBER expression accounted for 4.4% in the group of cardia carcinomas and 8.6% in the group of gastric cancers. These results indicate that EBV infection plays no etiologic role in primary small bowel adenocarcinomas. © 2006 Wiley‐Liss, Inc.
CEO compensation and the seasoned equity offering decision
Authors: F. Brazel Joseph , Webb Elizabeth 
Published: February 2006

AbstractEmpirical research on seasoned equity offerings indicates that the decision to make an SEO typically engenders a decline in firm value, as investors interpret this decision as a signal of poor financial health or that the stock is overpriced. Here, we add to the literature by analyzing the short‐term market reaction to SEO announcements and the chief executive officer's link to firm performance (i.e. the proportion of CEO equity‐based compensation). Results support the hypothesis that investors are more likely to view the announcement of an SEO as a last resort source of capital when the proportion of CEO equity‐based compensation is high. In such cases of high equity‐based compensation, our findings indicate that the SEO announcement provides an incremental signal of financial distress above that provided by financial statements. We also find this relationship (last resort signal) to be stronger when large information asymmetries exist between management and investors. Thus, managers should consider the ramifications of executive compensation structure when considering whether to make an SEO. Copyright © 2006 John Wiley & Sons, Ltd.
HIV‐1 integrase inhibitors: 2003–2004 update
Authors: Dayam Raveendra , Deng Jinxia , Neamati Nouri 
Published: February 2006

AbstractThe integration of viral cDNA into the host genome is an essential step in the HIV‐1‐life cycle and is mediated by the virally encoded enzyme, integrase (IN). Inhibition of this process provides an attractive strategy for antiviral drug design. The discovery of β‐diketo acid inhibitors played a major role in validating IN as a legitimate antiretroviral drug target. Over a decade of research, a plethora of IN inhibitors have been discovered and some showed antiviral activity consistent with their effect on IN. To date, at least two compounds have been tested in human but none are close to the FDA approval. In this review, we provide a comprehensive report of all small‐molecule IN inhibitors discovered during the years 2003 and 2004. Compilation of such data will prove beneficial in developing QSAR, virtual screening, pharmacophore hypothesis generation, and validation. © 2006 Wiley Periodicals, Inc. Med Res Rev
Surface mapping of binding of oviductin to the plasma membrane of golden hamster spermatozoa during in vitro capacitation and acrosome reaction
Authors: Kan Frederick W.K. , Esperanzate Patrick W.B. 
Published: February 2006

AbstractOviductins are high‐molecular‐weight glycoproteins synthesized and secreted by nonciliated oviductal epithelial cells and have been shown to play a role in fertilization and early embryo development. The present study was carried out to examine the in vitro binding capacity of hamster oviductin to homologous sperm and to determine the sites of its localization in untreated, capacitated, and acrosome‐reacted spermatozoa. Freshly prepared epididymal and capacitated sperm as well as acrosome‐reacted sperm were incubated with oviductal fluid prepared from isolated hamster oviducts, fixed and then probed with a monoclonal antibody against hamster oviductin. Results obtained with pre‐embedding immunolabeling experiments revealed binding of oviductin to the acrosomal cap and the apical aspect of the postacrosomal region. Immunolabeling of both regions appeared to be more intense in capacitated spermatozoa. Acrosome‐reacted sperm showed an immunoreaction of moderate intensity over the postacrosomal region. The plasma membrane overlying the equatorial segment also exhibited a weak labeling. Quantitative analysis obtained with the surface replica technique indicated that oviductin had a higher binding affinity for the acrosomal cap than the postacrosomal region and that the binding of oviductin to the latter plasma membrane domain was enhanced during capacitation. Binding of oviductin to the postacrosomal region, however, was attenuated after acrosome reaction. Immunolabeling for oviductin was found to be the weakest over the equatorial segment regardless of the experimental conditions. The binding of hamster oviductin to specific membrane domains of the homologous sperm and the changes in its distribution during capacitation and acrosome reaction may be important for the function of hamster oviductin preceding and during fertilization. Mol. Reprod. Dev. © 2006 Wiley‐Liss, Inc.
Effects of amino acid substitutions in and around the arginine‐glycine‐aspartic acid (RGD) sequence on fertilization and parthenogenetic development in mature bovine oocytes
Authors: Sessions B.R. , Aston K.I. , Davis A.P. , Pate B.J. , White K.L. 
Published: February 2006

AbstractIntegrins have been shown to be involved in the process of fertilization and many integrin–ligand interactions are mediated through the recognition of an arginine‐glycine‐aspartic acid (RGD) sequence. Despite the fact the RGD domain is a principal player in determining the functional characteristics of an adhesive protein, increasing evidence has accumulated implicating the amino acids flanking the RGD sequence in determining the functional properties of the RGD‐containing protein. A set of linear peptides in which the amino acid sequence in and around the RGD tri‐peptide was modified was synthesized to better understand the specificity of the RGD–receptor interaction. Mature oocytes were fertilized in vitro in the presence of RGD‐containing and RGD‐modified peptides. Both the RGD‐containing and RGD‐modified peptides impaired the ability of sperm to fertilize bovine oocytes, illustrated by a reduction in cleavage. The linear modified RGD containing peptides were also examined for their ability to induce parthenogenetic development with the objective of providing a linear RGD peptide with greater biological activity than the one (GRGDSPK) used previously (Campbell et al., 2000). The data demonstrate the specificity of the receptor for the RGD sequence, further implicate the involvement of integrins in the process of bovine fertilization, and illustrate the importance of the amino acids surrounding the RGD sequence in determining the binding and functional properties of RGD‐containing peptides. The data support the findings that a linear RGD peptide can block fertilization and that amino acids around the RGD sequence have an impact on the biological activity of the receptor. Mol. Reprod. Dev. © 2006 Wiley‐Liss, Inc.
Sympathetic skin responses in Type‐1 diabetic children: Relationship to urodynamic findings
Authors: Soylu Ahmet , Akinci Aysehan , Yilmaz Ugur , Sarier Mehmet , Aslan Mehmet , Ozcan Cemal 
Published: February 2006

AbstractAimsCystopathy is an important problem in diabetes mellitus (DM) when diabetes is not well‐controlled. In most cases of diabetic csytopathy, autonomic involvement is responsible, which develops insidiously over a long time. We investigated the hand and genital sympathetic skin responses (SSRs) and its relation to urodynamic abnormalities in this group of patients.MethodsWe performed hand and genital SSRs in 24 children with Type‐1 DM, whose hemoglobin A1C values were above normal limits. We also recruited 19 healthy children for SSRs measurements. Cystometry was performed in 24 children with Type‐1 DM. Based on cystometry findings, these children were classified into two groups as normal (n:6) and abnormal (n:18). The amplitude and latency of hand and genital SSRs of 24 children with Type‐1 DM and 19 healthy children were compared.ResultsHand and genital SSRs were obtained from all of the diabetic and healthy children. The mean genital SSRs amplitude in diabetic children was significantly lower than the controls. There was no difference in the mean values of all investigated parameters between the normal group and controls. When compared to the controls, there was prolonged latency and decreased amplitude of genital SSRs and decreased hand SSRs amplitude in abnormal group.ConclusionsSSR is a non‐invasive test for the evaluation of autonomic sympathetic involvement. Our study revealed differences in genital SSR before the manifestations of cystopathy. Children with abnormal urodynamic findings had changes in both hand and genital SSRs. These findings suggest that SSR tests may have a place in the evaluation of diabetic cystopathy in the early asymptomatic period. Neurourol. Urodynam. 25:243–248, 2006. © 2006 Wiley‐Liss, Inc.
Coarse grid classification: a parallel coarsening scheme for algebraic multigrid methods
Authors: Griebel Michael , Metsch Bram , Oeltz Daniel , Schweitzer Marc Alexander 
Published: February 2006

AbstractIn this paper, we present a new approach to the parallelization of algebraic multigrid (AMG), i.e. to the parallel coarse‐grid selection in AMG. Our approach involves (almost) no special treatment of processor subdomain boundaries and hence avoids a number of drawbacks of other AMG parallelization techniques. The key idea is to select an appropriate (local) coarse grid on each processor from a set of admissible grids such that the composed coarse grid forms a suitable coarse grid for the whole domain, i.e. there is no need for a special boundary treatment. To this end, we first construct multiple equivalent coarse grids on each processor subdomain. In a second step we then select exactly one grid per processor by a graph clustering technique. The results of our numerical experiments clearly indicate that this approach results in coarse grids of high quality which are very close to those obtained with sequential AMG. Furthermore, the operator and grid complexities of our parallel AMG are mostly smaller than those obtained by other parallel AMG methods, whereas the scale‐up behaviour of the proposed algorithm is similar to that of other parallel AMG techniques. However a significant improvement with respect to the speed‐up performance is achieved. Copyright © 2006 John Wiley & Sons, Ltd.
PTHrP‐independent hypercalcemia with increased proinflammatory cytokines and bone resorption in two children with CD19‐negative precursor B acute lymphoblastic leukemia
Authors: Niizuma Hidetaka , Fujii Kunihiro , Sato Atsushi , Fujiwara Ikuma , Takeyama Junji , Imaizumi Masue 
Published: February 2006

AbstractHypercalcemia in childhood acute lymphoblastic leukemia (ALL) is rare and occasionally associated with parathyroid hormone‐related protein (PTHrP). However, the pathogenesis of PTHrP‐independent hypercalcemia remains unclear. We report two children with precursor B ALL who had marked hypercalcemia (15.8 and 16.6 mg/dl, respectively) and disseminated osteolysis. Serum tumor necrosis factor‐α (TNF‐α) and IL‐6 were markedly elevated, whereas 1,25(OH)2 vitamin D3, intact PTH and PTHrP were decreased or undetected. Analysis of urinary deoxypyridinoline (DPY) or bone biopsy of the osteolytic lesion showed an increased bone resorption, and administration of bisphosphonate improved the hypercalcemia. Patients had ALL with immunophenotype positive for CD10, CD34, and HLA‐DR but negative for CD19 and obtained remission with chemotherapy. These findings suggest that increased osteoclastic bone resorption via stimulation with TNF‐α and IL‐6 may be mechanism causing PTHrP‐independent hypercalcemia in some patients with precursor B ALL lacking CD19 expression. Pediatr Blood Cancer 2007;49:990–993. © 2006 Wiley‐Liss, Inc.
HLA association is different in children and adults with severe acquired aplastic anemia
Authors: Führer Monika , Durner Jürgen , Brünnler Günter , Götte Heiko , Deppner Cornelia , Bender‐Götze Christine , Albert Ekkehard 
Published: February 2006

AbstractBackgroundSevere aplastic anemia (SAA) is defined as pancytopenia caused by bone marrow failure. The pathogenesis of SAA is thought to involve autoimmune processes. Increased susceptibility to autoimmunity has been shown to be associated with several different HLA alleles. In SAA, few large studies based on data mainly from adults describe a positive HLA correlation with HLA‐DR2 (DRB1*15) and HLA‐B14.ProcedureThis study explored the HLA constitution of 181 children with SAA who were enrolled in the prospective multi‐center study SAA94 between January 1994 and January 2002. The control group consisted of 303 healthy individuals of comparable demographic background. Allelic frequencies between patients and controls are compared using Fisher's exact test.ResultsIn our pediatric cohort, we describe a positive association with HLA‐B14 (P = 0.0039), but no association of HLA‐DR2 with SAA.ConclusionHLA associations appear to be different in children and adults with SAA. This might point towards a difference in pathophysiology between at least part of the children and adults. Pediatr Blood Cancer 2007;48:186–191. © 2006 Wiley‐Liss, Inc.