bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nodular goiter: A histo‐cytological study with some emphasis on pitfalls of fine‐needle aspiration cytology
Authors: Ruben Harach H. , Zusman Silvia B. , Saravia Day E. 
Published: February 2007

AbstractA comprehensive comparative histo‐cytological study of 48 nodular goiters from an endemic goiter region was undertaken. Practically all features observed on the biopsies were identified, although with less frequency, on the smears. In agreement with previous observations, characteristic components of nodular goiter (NG) in aspirates included small to medium size epithelial cells with regular round nuclei, honeycomb pattern, large follicles, papillae showing the previously mentioned epithelial features, oxyphilic cells, and moderate to abundant background colloid material and thyroid phagocytes (macrophages). All eight features occurred together in only 2% of the studied cases, seven in 6 (12.5%), six in 4 (8%), five in 6 (12.5%), four in 12 (25%), three in 6 (12.5%), two in 11 (23%), and one in 2 (4%) cases, respectively. Regardless of the number and combination of features present, specific identification of NG on the smears may not always be possible and diagnostic pitfalls include thyroid cyst, Hashimoto's thyroiditis, granulomatous lesions, and, more frequently, follicular neoplasia. Our findings suggest that thyroid aspirates should be analysed with critical clinico‐pathological approach and surgery considered only for nodules that are clinically suspicious or unresponsive to hormonotherapy when a diagnosis of follicular neoplasia is made.
Diagnosis of tuberculosis of bone and soft tissue by fine‐needle aspiration biopsy
Authors: Masood Shahla 
Published: February 2007

AbstractFine‐needle aspiration biopsy is a well‐established procedure in the detection of various neoplastic processes. However, there are only limited reports on the efficacy of this technique in nonneoplastic conditions. In this study, fine‐needle aspiration cytology findings of bone and soft tissue lesions in 11 patients with tuberculosis are reported. Spine, scapula, chest wall, flank areas, tibia, ring, and index fingers were the sites of fine‐needle aspiration biopsies. The age of the patients ranged from 21 to 65 years. Granulomatous reaction with or without caseation necrosis was seen in 73%. The aspirated material was acellular or predominantly composed of necrotic material and inflammatory infiltrates in 27%. Acid‐fast bacilli (AFB) could be demonstrated in 64%. Culture for Mycobacterium tuberculosis was positive in 83%. This study supports previous suggestions that fine‐needle aspiration biopsy is a simple alternative to open biopsy for the diagnosis of TB of bone and soft tissue lesions. © 1992 Wiley‐Liss, Inc.
Accuracy of diagnosis of malignant lymphoma by combining fine‐needle aspiration cytomorphology with immunocytochemistry and in selected cases, southern blotting of aspirated cells: A tissue‐controlled study of 86 patients
Authors: Cartagena Norberto , Katz Ruth L. , Hirsch‐Ginsberg Cheryl , Childs Craig C. , Ordóñez Nelson G. , Cabanillas Fernando 
Published: February 2007

AbstractFine‐needle aspiration (FNA) cytology of lymph nodes in malignant lymphoma is fraught with difficulty. In certain clinical situations, cytology has been documented to be useful in patients with malignant lymphoma. The intent of our investigation was to determine the accuracy of a multiparameter approach in diagnosing lymphoma. We reviewed the results of FNA cytology combined with the immunocytochemistry and, in some cases, the Southern blots of aspirated cell suspensions obtained from 86 suspected lymphoma patients who subsequently underwent surgical biopsy of the aspirated site. In four cases, in which FNA was unable to retrieve sufficient material for diagnosis, the histology showed extensive fibrosis. When the FNA diagnoses were compared with the histologic diagnoses, the diagnosis concurred in 69 cases (56 malignant lymphomas, 12 reactive, 1 atypical lymphoid proliferation). There was one false‐positive, six false‐negatives, and eight cases diagnosed as atypical lymphoid proliferation. Overall accuracy was 91%. There were two types of false‐negative cases: those in which a diagnosis of another malignancy or unspecified malignant neoplasm was made and those that were diagnosed as reactive when the histology showed lymphoma. In seven cases, the DNA rearrangement studies of the antigen receptor genes were successfully performed on the aspirated cells and were useful in establishing lineage and clonality of both B and T lymphoid cells.Our study indicated that the use of a multiparameter approach in the diagnosis of malignant lymphoma by FNA enhanced the accuracy of diagnosis of the non‐Hodgkin's lymphomas. In Hodgkin's disease, no benefit was derived from the approach. © 1992 Wiley‐Liss, Inc.
Fine‐needle aspiration biopsy diagnosis of rhabdomyosarcoma: Cytologic, histologic, and ultrastructural correlations
Authors: Akhtar Mohammed , Ali Muhammad Ashraf , Bakry Mohammed , Hug Mahmuda , Sackey Kwasi 
Published: February 2007

AbstractA series of 15 cases of rhabdomyosarcoma diagnosed by fine‐needle aspiration biopsy (FNAB) and confirmed by histopathology is reviewed. Cytologically, the tumors were composed of a variable mixture of cells, which according to the degree of differentiation were categorized as early, intermediate, or late rhabdomyoblasts. Histologically, the tumors were divided into embryonal 9, monomorphic round cell 4, and alveolar rhabdomyosarcoma 2. Comparison of histological and cytological features revealed that embryonal types were composed mainly of early rhabdomyoblasts. Recognition of these patterns may be helpful in FNAB diagnosis of rhabdomyosarcoma. © 1992 Wiley‐Liss, Inc.
Epidermoid cyst of the spleen: Diagnosis suggested by fine‐needle aspiration biopsy
Authors: Tuccari Giovanni , Giuffrè Giuseppe , Muscarà Maurizio 
Published: February 2007

AbstractThe authors report a case of epidermoid cyst of the spleen, in which cytologic findings were characteristic and suggested this diagnosis. Histologic and immunohistochemical findings are described in the attempt to clarify the histogenesis of this cystic lesion. © 1992 Wiley‐Liss, Inc.
Lipomas of anterior neck simulating thyroid nodules: Diagnosis by fine‐needle aspiration
Authors: Butler Sheila L. , Oertel Yolanda C. 
Published: February 2007

AbstractThe anterior neck is an unusual location for lipomas. Cervical lipomas can be mistaken for non‐functioning thyroid nodules. We report eight cases from our files diagnosed by fine needle aspiration (FNA). Our purpose is to call attention to this simple technique in establishing an accurate diagnosis and how it can contribute to better patient management by avoiding unnecessary thyroid suppressive therapy and/or surgery. We advocate using FNA as the initial diagnostic test on palpable masses in the neck. The differential diagnosis must include thyroid lipomatosis, thyrolipoma or adenolipoma, amyloid goiter with fatty infiltration, and fat‐containing thyroidal neoplasms (papillary carcinoma and follicular neoplasms). © 1992 Wiley‐Liss, Inc.
Processing of needle rinse material from fine‐needle aspirations rarely detects malignancy not identified in smears
Authors: Henry‐Stanley Michelle J. , Stanley Michael W. 
Published: February 2007

AbstractWhen preparing FNA smears, we recover material left in the needle hub by forcefully striking the open hub against a slide. Material in the syringe tip is expressed by repeated forceful blasts of air (needle unattached). We investigated the utility of recovering additional material by rinsing the needle and syringe. Saline was used to flush the needle and syringe tip repeatedly. All material was processed by cytocentrifugation. We studied 159 needle rinse (NR) specimens from 152 patients (breast = 70, lymph node = 30. lung = 15, soft tissue = 14, salivary gland = 12, thyroid = 12, liver = 5, branchial cleft cyst = 1). Malignancy was Identified in 21 FNAs (13%) from 21 patients (14%). All were diagnosed in smears (9 lung, 5 liver, 4 lymph node, 2 breast, 1 soft tissue). NR material identified 16 of these (76%). No case with benign smears (n = 138) showed malignancy in NR material. We conclude that if good technique is applied to preparation of smears and recovery of material from the needle hub and syringe tip, NR material will rarely identify additional malignancies. It thus represents an inefficient allocation of technical and human resources within the laboratory. However, NR may provide additional slides for special stains and may be useful for clinicians who do not always prepare high quality smears. Furthermore, the ease with which FNA of palpable masses can be repeated suggests that in the small number of cases requiring special stains, additional material can be readily obtained. Thus in the light of our data, there is probably little reason to prepare NR specimens in any but the most exceptional cases. © 1992 Wiley‐Liss, Inc.
Helicobacter (campylobacter) pylori in gastric brushing cytology
Authors: Edmonds Pamela R. , Carrozza Michael J. , Ruggiero Francesca M. , Calafati Stephanie A. , Jann Robert C. 
Published: February 2007

AbstractHelicobacter ( formerly Campylobacter) pylori is frequently associated with chronic gastritis and peptic ulcer and has been implicated as an etiologic agent. Identification of H. pylori is important for specific treatment with antibiotics and bismuth compounds. We studied 27 patients who presented with symptoms of gastritis or peptic ulcer on whom paired gastric biopsies and gastric brushings for cytology had been performed. Biopsies were stained with H & E and Warthin‐Starry or Giemsa for H. pylori. Previously, Papanicolaou‐stained brushings were restained with Giemsa and reviewed blindly by two cytologists. Cytologic examination revealed the characteristic 1‐3 μ curved or spiral gram‐negative bacilli embedded in mucus in 12 of 27 (44%) of cases. Biopsies showed H. pylori in 13 of 27 (48%) of cases. Cytology and histology were concordant in 22 of 27 (81%) of cases. Three cases were positive on biopsy, negative on cytology; two of these were unsatisfactory cytology specimens. Two cases were positive on cytology, negative on biopsy, apparently sampling artifacts. Papanicolaoustained slides were scored for several morphologic parameters; numbers of acute and chronic inflammatory cells and degree of cytologic atypia. None of these were predictive of the presence of H. pylori. We conclude that Giemsa‐stained gastric brushings are a useful complement to gastric biopsies in establishing the diagnosis of H. pylori. Diagn Cytopathol 1992;8:563‐566. © 1992 Wiley‐Liss, Inc.
Pulmonary mycetomas in immunocompetent patients: Diagnosis by fine‐needle aspiration
Authors: Stanley Michael W. , Deike Marcia , Knoedler John , Iber Conrad 
Published: February 2007

AbstractMycetomas usually grow within preexisting cavities and frequently lead to pulmonary hemorrhage. We describe four males, aged 38 to 72 years, in whom mycetomas were diagnosed by FNA. Preexisting cavitary lesions resulted from tuberculosis, anaerobic absess, and bullous lung disease (two cases). Fine needle aspiration yielded tangled mats of fungal hyphae (large and grossly visible in three cases) and acute inflammatory cells. The atypical cells often seen in the walls of such lesions were not identified. Cultures showed Aspergillus (3 cases) Pseudoallescheria boydii (1 case). The diagnosis was surgically confirmed in two cases. Two patients were too ill for surgery and the fourth refused. At 7 and 10 months, the two remaining individuals have pulmonary hemorrhage but no evidence of progression or malignancy. In poor surgical candidates, conservative management of mycetomas diagnosed by fine needle aspiration is appropriate. Excluding mycetoma secondary to cavitary lung carcinoma requires careful correlation of historical, clinical, radiographic, cytologic, and follow‐up data. © 1992 Wiley‐Liss, Inc.
Aspiration biopsy cytology of malignant papillary breast neoplasms
Authors: Dei Tos Angelo P. , Giustina Dino Della , Bittesini Lucia 
Published: February 2007

AbstractPapillary carcinoma of the breast is a rare neoplasm characterized by a low grade of malignancy. From the files of the Department of Histopathology of Conegliano Veneto City Hospital, Conegliano Veneto, Italy, 16 cases of papillary breast carcinoma diagnosed by fine‐needle aspiration cytology have been selected. A multiparametric morphologic study has been performed in order to contribute to the cytologic characterization of this rare group of breast malignancies. The authors believe that aspiration biopsy cytology is able to provide an accurate preoperative diagnosis.
Pulmonary aspergillosis: An unusual cytologic presentation
Authors: Stanley Michael W. , Davies Scott , Deike Marcia 
Published: February 2007

AbstractCytologic identification of Aspergillus is usually based on recognition of hyphal elements; conidia are rarely seen. We report a case of autopsy‐proven pulmonary Aspergillosis which was studied antemortem by bronchoalveolar lavage. This mass arose in the clinical setting of chronic necrotizing pulmonary aspergillosis. The specimen contained numerous conidia, some of which exhibited germination. No hyphae were seen. This unusual cytologic expression of clinically significant fungal disease could be easily overlooked. Distinction of Aspergillus conidia from contaminating pollen is discussed. © 1992 Wiley‐Liss, Inc.
Metastatic hepatocellular carcinoma of the breast, simulating gynecomastia: Diagnosis by fine‐needle aspiration biopsy
Authors: Nappi Oscar , Ferrara Gerardo , Lanniello Giovanni , Wick Mark R. 
Published: February 2007

AbstractHepatocellular carcinoma (HCC) may uncommonly present with distant metastasis in the absence of a documented neoplasm in the liver. The authors herein describe the case of a 60‐year‐old man with cirrhosis who developed unilateral enlargement of the breast and a subareolar mass. This problem was clinically thought to represent gynecomastia, but a mammary fine‐needle aspiration biopsy demonstrated a malignant epithelial neoplasm composed of large granular amphophilic cells. Bile pigment was visualized in the tumor on aspirate smears and cell block preparations; immunostains showed reactivity for cytokeratin and alpha‐fetoprotein, but there was no positivity for epithelial membrane antigen, gross cystic disease fluid protein‐15, vimentin, estrogen receptors, progesterone receptors, or S100 protein. These results indicated a diagnosis of metastatic HCC, which was subsequently confirmed by computed tomography of the abdomen. © 1992 wiley‐Liss, Inc.
Cystic nephroma: Cytologic findings in fine‐needle aspiration cytology
Authors: Drut Ricardo 
Published: February 2007

AbstractThis report presents the fine‐needle aspiration cytology (FNAC) findings of a multicystic renal tumor found in a 3‐year‐old child. The smears contained benign epithelial cells isolated or arranged in sheets of uniform cells strongly suggesting the lining of the cysts. The combination of the imaging data with the FNAC findings favoured the diagnosis of cystic nephroma (CN), a benign renal tumor that is cured by surgery. Surgical pathology confirmed the diagnosis. CN should be added to the list of tumors of the kidney in infancy that appear to be diagnosable by FNAC/biopsy.
Fine‐needle aspiration cytology of metastatic breast tumor originating from leukemia
Authors: Miura Hiroyuki , Konaka Chimori , Kawate Norihiko , Kato Harubumi , Miura Reiko , Ebihara Yoshiro 
Published: February 2007

AbstractTwo cases of metastatic breast tumor originating from leukemia are reported. Fine‐needle aspiration (FNA) specimens showed a large number of isolated small‐to‐medium‐sized atypical lymphocytic cells. It is difficult to distinguish metastatic breast tumors and primary breast cancers by physical findings alone. FNA cytology is an effective method for qualitative diagnosis. When atypical lymphocytic cells are obtained in aspiration materials of the breast, past history and general examination are necessary for diagnosis.In some cases of leukemia with breast involvement, good outcomes are obtained. Therefore, earlier detection is necessary in order to begin suitable therapy earlier and to avoid unnecessary excisional biopsy in patients with leukemia and breast tumors. To achieve this it is also necessary to first take into consideration the possibility of metastasis or infiltration of leukemia, and second to prepare two types of specimen for Papanicolaou stain and Giemsa stain before operation. © 1992 Wiley‐Liss, Inc.
Leiomyosarcoma of the orbit: Diagnosis of its recurrence by fine‐needle aspiration cytology
Authors: Das Dilip K. , Das Jayachandra , Kumar Dileep , Bhatt Naveen C. , Banot Kiran , Natarajan Radha 
Published: February 2007

AbstractAn 8 1/2‐yr‐old boy with proptosis was diagnosed to have low‐grade leiomyosarcoma of the orbit following lateral orbitotomy and histology of an incompletely excised intraconal mass. He received chemotherapy but had recurrence of proptosis at the age of 12 yr. Ultrasonography revealed a solid mass and its fine‐needle aspiration cytology features were consistent with recurrence of leiomyosarcoma. A year later, the cytodiagnosis was confirmed by histology of the excised tumor from a second lateral orbitotomy. Masson 's trichrome stain confirmed the smooth muscle nature of the neoplasm and ultrastructural features were in favor of leiomyosarcoma. The patient received intermittent chemotherapy, and is clinically free from disease at the age of 17 yr. © 1992 Wiley‐Liss, Inc.
Rounded atelectasis: Diagnosis by fine‐needle aspiration cytology
Authors: Miller Wallace T. , Gupta Prabodh K. , Grippi Michael A. , Miller Wallace T. 
Published: February 2007

AbstractRounded atelectasis, a rare, benign mass lesion, is most often seen in association with asbestos‐related pleural changes. Often a presumptive diagnosis can be made on the basis of characteristic CT and chest radiographic findings. However, not infrequently radio‐graphic imaging fails to differntiate rounded atelectasis from primary bronchogenic carcinoma, a disease which is seen with increased frequency in patients with asbestos exposure. We describe two cases where the diagnosis of rounded atelectasis was made by fine‐needle aspiration (FNA) cytology. The cytologic features included abundant pulmonary parenchymal material with thickened alveolar walls containing pulmonary macrophages and connective tissue. It is important to realize that this is a useful positive finding indicating rounded atelectasis, rather than a negative finding suggesting the absence of neoplasm. Needles with a cutting action may be necessary to obtain sufficient material to make the diagnosis of rounded atelectasis.
Peritoneal washing cytology in women: Diagnostic pitfalls and clues for correct diagnosis
Authors: Sneige Nour , Fanning Christina V. 
Published: February 2007

AbstractThe significance of peritoneal washing cytology in the management of patients with gynecologic cancer is well established. Its microscopic evaluation, however, is not always straightforward. Previous studies have identified some of the conditions that may result in misinterpretation of cytologic results. This report reviews the literature and describes other sources of diagnostic difficulties and clues for correct diagnosis. In addition, an outline for distinguishing endosalpingiosis from borderline and welt‐differentiated serous carcinoma is proposed.
Fine‐needle aspiration biopsies of metastatic neuroendocrine tumors in liver: Use of transmission electron microscopy and protein A gold technique in diagnosis
Authors: Ravinsky Esther , Quinonez Guillermo E. , Diocee Malkit S. 
Published: February 2007

AbstractFive fine‐needle aspiration biopsies of liver were studied to evaluate the use of electron microscopy and protein A gold technique in the diagnosis of metastatic neuroendocrine tumors. All five cases had cytologic features suggestive of neuroendocrine tumors and neurosecretory granules on ultrastructural examination.The aspirates were stained by the immunoperoxidase technique and the postembedding protein A gold technique using the antibody to chromogranin A. Three cases were positive for chromogranin A by both immunoperoxidase and protein A gold techniques. Two cases were positive by protein A gold technique and negative by immunoperoxidase technique.Confirmation of neurosecretory granules by immunochemistry is ideal, since ultrastructurally they can be mimicked by other electron‐dense inclusions. Advantage of the protein A gold technique is the use of the same material for both ultrastructural evaluation and the protein A gold technique.
Detection and typing of human papillomavirus DNA in the uterine cervix of japanese women by nonradioactive dot blot and southern blot hybridization
Authors: Konno Ryo , Sato Shinji , Yajima Akira 
Published: February 2007

AbstractHPV infection was examined with Cytobrush in exfoliated cervical cells sampled from 347 women. HPV DNA analysis was conducted in two steps. The presence of HPV DNA was demonstrated by dot blotting and typing of HPV DNA was made by Southern blotting using biotinylated probes. Of 167 cases with cervical intra‐epithelial neoplasia (CIN) and cervical carcinoma, HPV DNA was detected and typed in 25 cases (15.0%). HPV 16, 18, and 33 were found mainly, and no HPV 6 or 11 was detected. The frequency of HPV DNA was 7.1% of CIN I, 28.6% of CIN II, 54.5% of CIN III, and 50.0% of invasive carcinoma. HPV occurred in patients newly diagnosed as CIN at 25.8% and in those of diagnosed as CIN in the past and followed up, 7.6%. Of 180 healthy women, the screening test of F08830 was positive for HPV DNA in four women (2.2%). The present system proved to be useful for facilitating large‐scale clinical research.
Cytopathology of malignant mesothelioma: A study of its patterns and histological bases
Authors: Dibonito Luigi , Falconieri Giovanni , Colautti Isabella , Gori Daniela Bonifacio , Dudine Sandra , Giarelli Luigi 
Published: February 2007

AbstractWe have reviewed the effusion cytology of 51 cases of histologically proven malignant mesothelioma of the pleura (49 cases) and the peritoneum (2 cases). The patient group included 45 males and 6 females, aged 45‐83 yr. A cytological diagnosis of malignancy had been rendered on 43 cases, and in 30 of them it was consistent with, or at least suggestive of, a mesothelioma. Diagnostic clues, especially evident in epithelial and biphasic tumors were hypercellularity and/or morular aggregates of malignant cells showing scalloped borders and nuclei with dense chromatin and evident nucleoli. Cytomegaly with multinucleation was also frequently observed. Reactive mesothelial cells were often present along with other non specific features such as red blood cells, fibrin, necrotic debris. In 13 cases, a diagnosis of malignancy was entertained but mesothelioma, although considered, was not reported out because of scantiness of material. In four cases, adenocarcinoma was erroneously diagnosed for the presence of deceptive cell vacuoles. In eight cases, no diagnostic cells were recovered in repeated effusions. The first diagnosis was a cytologic one in 37 patients. Tissue study was performed on autopsy (35 patients) and surgical material. The latter was the only source of histology in six cases. Immunocytochemical investigation was negative for carcinoembryonic antigen in all but one tested cases (1/21) and positive for human milk fat globulin in about one‐half of the epithelial and biphasic tumors. In 18 of 21 cases, positivity for combined high‐and low‐molecular‐weight keratins was detected. The results of our survey indicate that conventional cytology permits accurate identification of either reactive and neoplastic mesothelial cells. The distinction between mesothelioma and adenocarcinoma may be further attempted using immunocytochemistry, combining a few commonly available markers, although the results should be carefully evaluated in view of their lack of specificity.