bluuebunny/crossref_metadata_2025_split huggingface dataset:
Periosteal Hypertrophy Following Administration of Prostaglandin E1: Biopsy Findings
Authors: Sato Yuichi , Okishima Takahiro , Matsuoka Yuji , Yamamoto Kazuhiro , Sennari Eiichi , Hayakawa Kunio 
Published: October 2007

AbstractSince prostaglandin E1> (PGE1) has been used for congenital cyanotic heart diseases of PDA‐dependent type due to its ductus dilatation effect, it is now possible to perform shunt operations with recovery of the general condition. Simultaneously, however, various side effects have been reported. In recent years, periosteal hypertrophy has been attracting attention as a side effect after long‐term administration of PGE1. In this study, the authors administered 0.03 μg/kg/min of PGE1 intravenously to an infant with a single ventricle and pulmonary atresia from the 7th day after birth.On the 9th day after the onset of administration, swelling and pain appeared in the lower limbs and later in the upper limbs. X‐rays of the lesions revealed hypertrophy of the periosteum. After administering PGE1 for 98 days, a shunt operation was performed, and a biopsy of the right tibia was conducted. Microscopic examination of the biopsy specimen showed marked new osteogenesis due to woven bones, and resorption, including osteoclasts, presumably attributable to a reaction specific to woven bones.
Alport's Hereditary Nephritis with the Nephrotic Syndrome
Authors: Okada Kaname , Shimokawa Tatsuo , Ichioka Takao , Yano Ichiro , Kawakami Koichiro , Kagami Shoyoji , Miyao Masuhide 
Published: October 2007

AbstractHistopathological changes were studied in renal biopsy specimens from a ten‐year‐old boy diagnosed as having Alport's hereditary nephritis with the nephrotic syndrome. Biopsy specimens of the kidney showed mild hypercellularity with an increase of mesangial matrix, irregular thickening of the capillary walls in the glomeruli, and numerous clusters of interstitial foam cells by light microscopy.Granular deposits of IgG, IgM, C3 and fibrinogen were seen along the capillaries and partially in the mesangium by immunofluoroscopy.Ultrastructurally, the lesions had various abnormalities of the glomerular basement membrane, including splitting, thinning, disruption, reticulation and irregular thickening. The mesangial matrix was increased and intramembranous deposits were observed. Foam cells were seen among both tubular and interstitial cells.
Histopathological Changes and Tissue Copper Concentrations of Menkes' Kinky‐hair Syndrome
Authors: Okada K. , Inaba H. , Miyao M. 
Published: October 2007

AbstractHistopathological changes and copper concentrations in various organs were studied in an autopsy case of Menkes' kinky‐hair syndrome (MKHS) after treatment of the disease by copper supplementation for about three years. In the central nervous system, the principal abnormality was extensive nerve cell loss and gliosis, especially severe in the cerebral and cerebellar cortex and medial thalamic nuclei. Marked decrease was found in the number and somal sprouts of Purkinje' cells in the cerebellum. Other abnormalities were marked hypoplasia of the thymus associated with an aberrant thyroid gland, vacuolated nuclei (intranuclear glycogen) in hepatic cells and pyelonephritis in both kidneys in addition to arterial changes and multiple diverticulosis of the bladder.The level of copper was highest in the kidney and slightly elevated in the spleen and jejunum, but low in the brain and liver.No renal tubular damage was found, such as that observed in heavy‐metal introxication, but this study suggestes that marked copper accumulation may have occurred in the kidney of this patient with consequent renal tubular damage as a result of prolonged copper infusion therapy.
Four Cases of Left Aortic Arch and Right Descending Aorta
Authors: Kimura Kazuhiro , Osano Mitsuru , Oikawa Tadao , Tsuji Atsutoshi , Morikawa Yoshiyuki , Kojima Yoshibumi , Wakabayashi Ryo 
Published: October 2007

AbstractWe studied 4 cases of left aortic arch and right descending aorta. Swallowing disturbance and vomiting were observed in one case. In the other cases, there were no symptoms related to esophageal or tracheal compression.The embryology of this developmental anomaly is not yet completely defined. Each of our 4 cases showed hypoplasia of the left aortic arch. We, therefore, consider that this anomaly may be a result of switching of the regression of the 4th branchial arch.
A Case of Bilateral Renal Dysplasia with Dandy‐Walker Syndrome and Tapetoretinal Degeneration
Authors: Tsuru Noboru , Mitsudome Akihisa , Oda Teiichi 
Published: October 2007

AbstractWe treated a 5 year and 9 month old Japanese boy, with symptoms of congenital blindness due to tapetoretinal degeneration and Dandy‐Walker syndrome who died of renal insufficiency. The autopsy findings of the kidney revealed bilateral dysplasia with cysts. These findings were compared to similar abnormalities occurring simultaneously in the eye, brain and kidney (oculocerebro‐renal syndrome) which has been considered as a new syndrome.Among the case reports of this syndrome, we are the first to describe the case with Dandy‐Walker syndrome.
Plasma Big Gastrin and Gastric Secretion in Newborns and Infants:Part 2: Plasma Big Gastrin and Gastric Secretion in Hypertrophic Pyloric Stenosis
Authors: Sato Mitsuyoshi 
Published: October 2007

AbstractTo elucidate the etiological role of big gastrin in hypertrophic pyloric stenosis (HPS), the pattern of plasma gastrins, the response of plasma big gastrin aftermilk feeding and the gastric secretion were investigated in 22 infants with HPS. In addition, histochemical study of the antral gastrin cells was carried out.The pattern of plasma gastrins in HPS was closely similar to that in the normal infant and big gastrin was a dominant component of circulating gastrins. The mean big gastrin level in HPS was significantly higher than that of the controls both fasting and after feeding. The HPS also had hypersecretion, of gastric juice, acid and pepsin before and after pentagastrin stimulation, Therefore, the HPS had both hypersecretion of gastric acid and hypergastrinemia. The number and the distribution of gastrin cells in the antral mucosa in HPS were similarly found by immunostainings with two antisera, anti‐big gastrin serum and anti‐gastrin serum. These gastrin cells were not different in number from those of infants and children with other diseases.These data suggest that the HPS has an incomplete negative feedback mechanism between plasma gastrin level and gastric acid secretion, and generally has hypergastrinemia whose trophic effect may play a role in the pathogenesis of this disease
Effect of Sulfisoxazole on Bilirubin‐Albumin Binding in Gunn Rats
Authors: Shimabuku Roberto , Nakamura Hajime , Matsuo Tamotsu 
Published: October 2007

AbstractHyperbilirubinemic Gunn rats were used to study sulfisoxazole‐mediated displacement of bilirubin from albumin. Bilirubin not bound to albumin or unbound bilirubin, which can enter the brain and cause damage, was measured by the automated peroxidase micromethod using the UB‐Analyzer. When sulfisoxazole was added to the rat serum in vitro, it showed measurable displacing competition with bilirubin for the binding sites on albumin. The bilirubin titration curves of hyperbilirubinemic sera, after injection of sulfisoxazole, showed a shift to the left indicating that the drug effectively lowered the capacity of serum albumin to bind to bilirubin. The bilirubin binding affinity of the first binding site on the albumin decreased with the administration of 25 mg/kg or more of sulfixazole. The serum concentration of both total bilirubin and unbound bilirubin decreased after the injection of sulfisoxazole suggesting their diffusion into extravascular compartments.
Selective enhancement of human IgE production in vitro by synergy of pokeweed mitogen and mercuric chloride
Authors: Kimata Hajime , Shinomiya Keisuke , Mikawa Haruki 
Published: October 2007

AbstractSelective stimulation of IgE production by pokeweed mitogen (PWM) plus mercuric chloride (HgCl2) was further investigated in peripheral blood mononuclear cells (MNC) from non‐atopic donors, who are high and low responders to PWM stimulation with respect to IgG, IgM and IgA production, and from various patients with elevated serum IgE levels.Non‐atopic high responders showed a strong selective increase in IgE plaque forming cells (PFC) without changes in IgG, IgM and IgA PFC, whereas low responders showed a slight increase in IgE PFC only when B cells were co‐cultured with mitomycin C (MMC)‐treated T cells. In patients with elevated serum IgE levels, PWM plus HgCl2 caused a variable selective increase in IgE PFC, however, there was no correlation between IgE PFC production and serum IgE levels.
Intestinal Absorption of Ovalbumin: The Concentration of Ovalbumin and IgG‐Antibody to Ovalbumin in Serum and Breast Milk after Oral Administration of Raw Egg
Authors: Kageyama Sachiko 
Published: October 2007

Abstract27 children with bronchial asthma were given raw eggs orally, and the concentration of ovalbumin (OA) and IgG‐antibody to OA in serum were measured 2 and 8 hours after eggs were given. In one‐third of the children the concentration of OA in serum increased after the ingestion of eggs. Allergic symptoms were developed without relation to the concentration of OA in serum. The concentration of OA in serum of children with high titer of IgG‐antibody to OA did not increase except for one.Three nursing mothers were given raw eggs orally, and the concentration of OA in serum and in breast milk were measured. The concentration of OA in serum of all three mothers increased and that of OA in breast milk of two mothers also increased.PA These results suggested that OA of raw egg were absorbed from intestinal tract in normal condition and that the permeability of the intestinal mucosa were not related so much with aging and allergic symptoms. The concentration of OA in serum appeared to be related with IgGantibodies to OA. The elevation of the concentration of OA in serum and in breast milk after ingestion of raw eggs suggested the possibility of sensitization with food antigen during fetal and breast‐fed period.
Effect of “Shoseiryu‐to” on Asthmatic Children and Guinea PIG Tracheal Smooth Muscle
Authors: Umesato Yoshihiro , Likura Yoji , Lnui Hiroyuki , Obata Toshihiko , Nishikawa Kazuko , Masaki Takuro , Nagakura Toshikazu 
Published: October 2007

AbstractSixty‐five asthmatic children were administered with “Shoseiryu‐to” for long time and as a result of following the children its effective ratio was 74.8%. After ten asthmatic children were administered with “Shoseiryu‐to”, their PEFR had a tendency to increase and their EIA had a tendency to be controled.Spiral sample of tracheal smooth muscle, which was extracted from a guinea pig after its death, was placed in a solution of Tyrode's medium. Various concentration of extracted solution from “Shoseiryu‐to” were added in turn to the chamber which contained the spiral sample. Tracheal smooth muscle was relaxed by “Shoseiryu‐to” and when it was contracted by histamine, it was also relaxed by “Shoseiryu‐to”.Nineteen asthmatic children were administered with “Shoseiryu‐to” and their serum cortisol, ACTH and free fatty acid were examined. The results of the examination in the group given “Shoseiryu‐to” were as follows: cortisol increased after thirty minutes and then at one hour intervals (P<0.01) and ACTH was found to be increased at every examination period (P<0.01).
Early Diagnosis of Wheezing Infants
Authors: Akasaka Toru 
Published: October 2007

AbstractOne hundred wheezy infants were diagnosed by “Asthma Prospective Score” initially and followed for 5 years. The score consists of major criteria (1) family history of major allergies, (2) high serum IgE level and minor criteria 1 family history of minor allergies, 2 age of onset after 6 months, 3 wheeze between March and October, 4 other allergic signs, 5 eosinophilia in the nasal smear, 6 remarkable improvement by the subcutaneous epinephrine. The infants with either two major criteria or one major and 3 or more minor criteria were diagnosed as asthma and less than these as bronchiolitis prospectively. There were significantly higher incidence of atopic family, high IgE, age of onset and other allergic signs (P<0.01), and response to epinephrine (P<0.02). And good correlation was found between diagnosis based on this score and final diagnosis, 61 out of 66 asthmatics (92.4%) and 27 out of 34 bronchiolitis group (79.4%). It is concluded that this scoring system could help us to make the diagnosis of asthma in early infancy.
McArdle Disease: Familial Variety of Muscle Phosphorylase Activity in Two Siblings
Authors: Maekawa Kihei , Shimizu Hiroshi , Eto Yoshikatsu , Nonaka Ikuya 
Published: October 2007

AbstractTwo siblings with McArdle disease were studied biochemically and histochemically. Case 1 was a 9‐year‐old girl and case 2 was a 14‐year‐old boy. No elevation of serum lactate after exercise was noticed in both cases. PAS staining in case 1 was markedly increased, whereas in case 2 it was moderately increased. Muscle glycogen content in case 1 was 51 mg/gr muscle and in case 2 it was 38.7 mg/gr (control: 11.2 ± 1.28 mg/gr). Muscle phosphorylase activity was completely absent in case 1 and was about 50% of normal value in case 2, by both determinations of histochemical and direct biochemical methods. SDS‐polyacrylamide gel electrophoresis revealed a little amount of muscle phosphorylase protein in both cases and also no abnormal migration of residual activity of muscle phosphorylase was found on polyacrylamide electrophoresis. These data indicate that occurrence of familial variety of muscle phosphorylase in two siblings was due to difference of muscle phosphorylase activity and also different onset of disease and clinical severity among two cases are depending on the degree of residual amount of the enzyme.
Epidemilogy of Insulin‐Dependent Diabetes Mellitus in Korea
Authors: Moon Hyung Ro 
Published: October 2007

AbstractThe prevalence of diabetes mellitus in the age group5–16 years, determined from 13,152 subjects residing in Kwangju, Chonnam Provice was 0.099 per cent or 98.9/100,000 in a study performed from December, 1976 to June 1977. On the other hand an epidemiologic study carried out on 254,835 subjects in the age groups14–15 and17–18 years from March 1981 to March 1982 in Seoul City revealed on overall prevalence of 7.85/100,000. In a retrospective study, 88.0/100,000 or out of a total of 10,228 pediatric inpatients were confirmed casesw of insulin‐dependent diabetes mellitus, during 7 years and 2 months (from january 1974 to March 1981) at a general hospital located in Jeonju City. The wide range in the prevalence and incidence figures of diabetes mellitus in Korean children probably resulted from lack of uniformity in epidemiological methodology and the degree of ascertainment.The adge distribution at onset of diabetes mellitus showed a gradual incdrease and peak incidences at 3,8 and 12 years of age. The4 sex difference in incidence was not obvious, though girls slightly outnumbered boys. Seasonal variation at onset of diabetes mellitus showed the highest frequency of new cases in winter and spring months.
HLA in Japanese Insulin‐Dependent Diabetes Mellitus
Authors: Juji Takeo , Maeda Hiroo , Tokunaga Katsushi , Ishiba Shintaro , Maruyama Hiroshi 
Published: October 2007

AbstractNinety‐four Japanese patients with insulin‐dependent diabetes mellitus (IDDM) and 388 healthy randomly selected Japanese were HLA typed. Significantly increased frequencies of Bw54, Cwl, DR4, B17 (Bw58), DR3 and DRw9 were observed. Simultaneously, the frequencies of Bw52 and DR2 in the patients were found to be significantly low as compared with those in helathy Japanese controls. It was suggested that one of the susceptibility genes to IDDM, which is associated with B8, DR3 haplotypes in Caucasoids, might be associated with B17 (Bw58), DR3 haplotypes in Japanese and in Chinese. Another susceptibility gene to IDDM associated with DR4 in Caucasoids might be associated with both DR4 and DRw9 in Japanese. A very rare variant of properdin factor B allotypes (BF*FT or BF*F075) was shown to be associated significantly with Japanese IDDM and with Bw52, DRw9 haplotypes.
Immune Mechanisms in the Etiology of lnsulin‐Dependent Diabetes Mellitus
Authors: Ludvigsson Johnny 
Published: October 2007

AbstractDifferent environmental factors such as virus infections or toxic agents may play a role in the etiology of insulin‐dependent diabetes mellitus, but it is evident that hereditary factors also are important. These two basic components can be unified into one common etiological mechanism, the immunological. Several facts support this hypothesis, which is reviewed in this paper. The theory now seems strong enough to justify trials to interfere with the immune response at the onset of diabetes in an effort to change the gradual loss of beta cell function.
Control Parameters in the Management of IDDM
Authors: Weber Bruno 
Published: October 2007

AbstractWell‐being, physical capacity, growth and development, emotional stability, and even clinical symptoms such as thirst and polyuria, appear to be rather insensitive parameters of control in young patients with insulin‐dependent diabetes mellitus (IDDM), reflecting only inadequately the actual state of health and the current metabolic condition. An effective supervision of the adequacy of treatment requires periodic physical checkups by an expert physician and permanent (i.e. daily) monitoring of the metabolic state by the patient himself.Of all accessible metabolic parameters, blood glucose and urinary glucose excretion seem to be most important, reflecting best the usually wide range of metabolic fluctuations during the day. Both can easily be measured repeatedly, using semiquantitative method and interpreted by the patient. However, only if adequate consequences such as necessary changes in therapy are taken, this sort of self‐monitoring is useful. Furthermore, the patient needs to be assured that his own measurements are correct, by both laboratory controls and by determinations of glycosylated proteins, in particular HbA1, which integrate glycaemia during his red cells' life span and are well suited to complement self‐monitoring. Compared to glucose, blood lipids, urinary ketone bodies, and C‐peptide or free insulin concentrations only serve as additional parameters of more limited importance, most of which require laboratories and are not available for every‐day therapeutic decisions.
Early Diagnosis of So‐Called Late Complications in Type 1 Diabetic Children
Authors: Chiumello Giuseppe , Meschi Granco , Beccaria Luciano , Morandi Rancesco , D'Arcais Alberto Flores , Bianchi Cesare 
Published: October 2007

AbstractPrevention of late complications is the main problem in type 1 diabetes of childhood. Longitudinal studies of subjects diagnosed before puberty demonstrated significant prevalence of retinopathy, nephropathy and neuropathy after 10‐ 15 years, correlated with the duration of diabetes. Proliferative retinopathy is rarely observed in children with diabetes of less than 5 years duration but vitreous fluorophotometry has shown abnormalities of retinal vessels in asymptomatic patients. In early diabetes glomerular permeability can be tested by radioimmunoassay of microalbuminuria; values above 30 mcg/min are a good predictor of later clinical proteinuria. The development of overt neuropathy is extremely variable and it may not be present even after many years of poorly controlled diabetes.Vitreous fluorophotometric abnormalities, basal and post‐exercise microalbuminuria and reduction of nerve conduction velocity have been proven to be reversible with intensive therapy. When secalled “late” complications are diagnosed early, careful and intensive therapy to maintain metabolic equilibrium near normal is called for.
T Cell Subset and Steroid Sensitivity in Idiopathic Nephrotic Syndrome in Children
Authors: Takahashi Yoshihiro 
Published: October 2007

AbstractThe relationship between T cell subset of peripheral blood lymphocytes and steroid sensitivity was studied in children with idiopathic nephrotic syndrome (INS). The subjects were 28 INS children, aged 2 to 16 years. T cells bearing receptors for IgG (Tγ) were identified by double rosette assay with sheep erythrocytes and IgG‐sensitized ox erythrocytes. T cells bearing receptors for IgM (Tμ) were identified by IgM‐sensitized ox erythrocytes rosette assay in purified T cells after incubating overnight.In steroid sensitive INS children, decreased numbers of Tγ cells and increased numbers of Tμ cells in onset or relapse were found and they were normalized with corticosteroid administration. Tγ cells of steroid nonsensitive INS children remained decreased even after steroid therapy.Tγ cells have been suggested to be, at least in part, suppressor T cells. Alteration of peripheral blood Tμ cells in this observation therefore may suggest the abnormality of suppressor T cells in INS children.
Tghe Presence of Common Precursor for Basophils and Eosinophils
Authors: Saito Hirohisa , Ito Tadaatsu , Nakamura Hironori , Joh Kosuke 
Published: October 2007

AbstractWhen human bone marrow cells were incubated in the presence of medium conditioned by PHA‐stimulated leukocytes (PHALCM) in methylcellulose culture, small compact colonies grew. The compact colonies were identified to consist of eosinophils, using Wright and Giemsa staining. However, among som of the eosinophilic colonies, several mixed granule leukocytes containing both basophilic and eosinophilic granules (but not basophils) were identified using astra blue‐biebrich scarlet staining. When some of the eosinophilic colonies were transferred into liquid suspension culture containing PHALCM, the growth of mixed granule leukocytes and basophils was observed in the culture. These results show that basophils and eosinophils may have a common precursor.
Authoritarian Paternal Attitude Inter‐Generational Transmission
Authors: Peretti Peter O. , Statum Jo Ann 
Published: October 2007

AbstractThe present research was conducted to determine authoritarian paternal attitude inter‐generational transmission. Factor analysis of the results suggested that authoritarian paternal attitudes could be indicated in terms of five factors, namely: Dominant, Rigidity, Conformity, Intoleratn, and Uncreative. In general, the sons expressed strongly the authoritarian attitudes of the fathers. Moreover, there were few significant differences Between the paternal attitudes of the fathers and sons.
Congenital Hypoprothrombinemia: The First Reported Case in Japan
Authors: Fujimura Yoshihiro , Nakaue Noriko , Sugimoto Mitsuhiko , Matsuyama Ikuko , Takase Toshio , Yoshioka Akira , Fukui Hiromu 
Published: October 2007

AbstractA Japanese boy with congenital hypoprothrombinemia, who was discovered in the newborn period when umbilical bleeding occurred, is described. On the 6th day after birth, the patient was found to have a markedly low thrombotest and prolonged prothrombin time and partial thromboplastin time. The administration of vitamin K failed to correct the coagulation defects, and the specific coagulation and immnological assay disclosed an extreme decrease of prothrombin activity and antigen. A slight increase of prothrombin activity and antigen in the patient was observed during the first year of life. The half‐lives of prothrombin activity and antigen were both10–11 hrs in the first phase, and32–33 hrs in the second phase. The inheritance mode of the disease seemed to be an autosomal recessive from the test results of the family members.