bluuebunny/crossref_metadata_2025_split huggingface dataset:
L-Selectin Facilitation of Metastasis Involves Temporal Induction ofFut7-Dependent Ligands at Sites of Tumor Cell Arrest
Authors: Läubli Heinz , Stevenson Jennifer L. , Varki Ajit , Varki Nissi M. , Borsig Lubor 
Published: February 2006

AbstractHematogenous carcinoma metastasis is supported by aggregated platelets and leukocytes, forming tumor cell emboli. Early tumor cell-platelet interactions can be mediated by P-selectin binding to tumor cell surface ligands and this process is blocked by heparin. We previously showed that L-selectin deficiency also attenuates experimental metastasis. However, the mechanisms and timing of L-selectin action remained unknown. Here, we study how L-selectin facilitates establishment of pulmonary metastatic foci in syngeneic mice by using experimental metastasis to time events following entry of tumor cells into the bloodstream. Although L-selectin deficiency did not affect platelet aggregation or initial tumor cell embolization, the association of leukocytes with tumor cells was reduced and tumor cell survival was diminished 24 hours later. Temporal inhibition of L-selectin by a function-blocking antibody reduced metastasis. Moreover, although selectin blockade by heparin 6 to 18 hours after tumor cell injection was synergistic with P-selectin deficiency in reducing metastasis, there was no further effect in L-selectin-deficient animals. Thus, heparin apparently works at these time points primarily by blocking L-selectin. Endogenous L-selectin ligands were concomitantly induced adjacent to established intravascular tumor cell emboli in a similar time window when leukocytes were also present. Metastasis was attenuated in mice missing these induced endogenous L-selectin ligands due to fucosyltransferase-7 deficiency. Thus, L-selectin facilitation of metastasis progression involves leukocyte-endothelial interactions at sites of intravascular arrest supported by local induction of L-selectin ligands via fucosyltransferase-7. These data provide the first explanation for how leukocyte L-selectin facilitates tumor metastasis. (Cancer Res 2006; 66(3): 1536-42)
Messenger RNAs under Differential Translational Control in Ki-ras–Transformed Cells
Authors: Spence Jean , Duggan Brendan M. , Eckhardt Colleen , McClelland Michael , Mercola Dan 
Published: January 2006

Abstract
Microarrays have been used extensively to identify differential gene expression at the level of transcriptional control in oncogenesis. However, increasing evidence indicates that changes in translational control are critical to oncogenic transformation. This study identifies mRNA transcripts that are differentially regulated, primarily at the level of translation, in the immortalized human embryonic prostate epithelial cell line 267B1 and the v-Ki-ras–transformed counterpart by comparing total mRNA to polysome-bound mRNA by using Affymetrix oligonucleotide microarrays. Among the transcripts that were identified were those encoding proteins involved in DNA replication, cell cycle control, cell-to-cell interactions, electron transport, G protein signaling, and translation. Many of these proteins are known to contribute to oncogenesis or have the potential to contribute to oncogenesis. Differential expression of RNA-binding proteins and the presence of highly conserved motifs in the 5′ and 3′ untranslated regions of the mRNAs are consistent with multiple pathways and mechanisms governing the changes in translational control. Although Alu sequences were found to be associated with increased translation in transformed cells, an evolutionarily conserved motif was identified in the 3′ untranslated regions of ephrinB1, calreticulin, integrinα3, and mucin3B that was associated with decreased polysome association in 267B1/Ki-ras. (Mol Cancer Res 2006;4(1):47–60)
Heregulins Implicated in Cellular Functions Other Than Receptor Activation
Authors: Breuleux Madlaina , Schoumacher Fabrice , Rehn Daniel , Küng Willy , Mueller Heinz , Eppenberger Urs 
Published: January 2006

Abstract
Heregulins (HRG) are known as soluble secreted growth factors that, on binding and activating ErbB3 and ErbB4 cell surface receptors, are involved in cell proliferation, metastasis, survival, and differentiation in normal and malignant tissues. Previous studies have shown that some HRG1 splice variants are translocated to the nucleus. By investigating the subcellular localization of HRGα1-241, nuclear translocation and accumulation in nuclear dot-like structures was shown in breast cancer cells. This subcellular distribution pattern depends on the presence of at least one of two nuclear localization sequences and on two domains on the HRG construct that were found to be necessary for nuclear dot formation. Focusing on the nuclear function of HRG, a mammary gland cDNA library was screened with the mature form of HRGα in a yeast two-hybrid system, and coimmunoprecipitation of endogenous HRG was done. The data reveal positive interactions of HRGα1-241 with nuclear factors implicated in different biological functions, including transcriptional control as exemplified by interaction with the transcriptional repressor histone deacetylase 2. In addition, HRGα1-241 showed transcriptional repression activity in a reporter gene assay. Furthermore, a potential of HRG proteins to form homodimers was reported and the HRG sequence responsible for dimerization was identified. These observations strongly support the notion that HRG1 splice variants have multifunctional properties, including previously unknown regulatory functions within the nucleus that are different from the activation of ErbB receptor signaling. (Mol Cancer Res 2006;4(1):27–37)
A Constitutively Active Lck Kinase Promotes Cell Proliferation and Resistance to Apoptosis through Signal Transducer and Activator of Transcription 5b Activation
Authors: Shi Mingjian , Cooper John C. , Yu Chao-Lan 
Published: January 2006

AbstractLck is a Src family protein tyrosine kinase and is expressed predominantly in T cells. Aberrant expression or activation of Lck kinase has been reported in both lymphoid and nonlymphoid malignancies. However, the mechanisms underlying Lck-mediated oncogenesis remain largely unclear. In this report, we establish a tetracycline-inducible system to study the biochemical and biological effects of a constitutively active Lck mutant with a point mutation at the negative regulatory tyrosine. Expression of the active Lck kinase induces both tyrosine phosphorylation and DNA-binding activity of signal transducer and activator of transcription 5b (STAT5b), a STAT family member activated in a variety of tumor cells. The active Lck kinase interacts with STAT5b in cells, suggesting that Lck may directly phosphorylate STAT5b. Expression of the constitutively active Lck mutant in interleukin-3 (IL-3)–dependent BaF3 cells promotes cell proliferation. In addition, the active Lck kinase protects BaF3 cells from IL-3 withdrawal-induced apoptotic death and leads to IL-3-independent growth. These transforming properties of the oncogenic Lck kinase can be further augmented by expression of exogenous wild-type STAT5b but attenuated by a dominant-negative form of STAT5b. All together, our results suggest the potential involvement of STAT5b in Lck-mediated cellular transformation. (Mol Cancer Res 2006;4(1):39–45)
Athena and the Paphlagonian in Aristophanes' Knights. Re-considering Equites 1090-5, 1172-81
Authors: Lauriola Rosanna 
Published: January 2006

AbstractThis paper re-examines the treatment of Athena in some passages of Aristophanes' Knights along the lines of a previous study by C.A. Anderson (1991 and 1995). Two topics will be considered: the dream-oracles of Athena (Eq. 1090-5), and some epithets characterizing the goddess during the food-serving contest (Eq. 1172-81). The Paphlagonian's and Sausage-Seller's portraits of Athena are self-referential images in that they are able both to play a significant 'dramatic' role in the contest for the steward-ship of Dêmos, by preparing for the final fate of each character within the comic plot (Eq. 1090-5), and to mirror, respectively, the war-mongering, grasping and violent nature of Cleon (Eq. 1172-81), and the poet's and Athenians' political ideal. By focusing on the self-referential nature of the Paphlagonian's portrait of Athena, I shall argue that Athena's image also resonates with a particular trait of Cleon, which is a constant object of Aristophanes' denunciation concerning the manipulative politics of the demagogue, i.e. his tendency to make people believe that the polis' welfare is his main concern; in other words, his pretense to be a good leader, sincerely interested in the citizens' well-being. This meaning of the Paphlagonian's portrait of Athena is corroborated by the characterization of the goddess through specific epithets in the food-serving contest.
Sicilicissitat (Plautus, Menaechmi 12) and Early Geminate Writing in Latin (with an Appendix on Men. 13)
Authors: Fontaine Michael 
Published: January 2006

Abstract1. The morphologically anomalous word sicilicissitat in v. 12 of Plautus' Menaechmi is, I argue, a Joycean 'portmanteau', or punning composite word coined for the nonce, meaning, simultaneously, the plot (i) 'affects a Sicilian atmosphere', from the Greek verb σικελιζειν, and (ii) 'is double' or 'counts twice', from the Latin noun sicilicus, a diacritical mark which served as a nota for gemination of consonants. 2. Although the evidence is inconclusive, I suggest that, on the strength of the pun, we can retrodate the period in which sicilici were used to the era before Ennius' arrival in Rome in 204 BC. 3. (Appendix) In Men. 13 read antēloquium, not antelogium.
Rusticitas Versus Urbanitas in the Literary Programmes of Tibullus and Persius
Authors: Tzounakas Spyridon 
Published: January 2006

AbstractTibullus and Persius are characteristic examples of poets who in their programmatic poems take a stance as to the literary juxtaposition of rusticitas and urbanitas and side with the first. Thus, they express their opposition to the mores of urban society and support the rustic way of life, which points to moral probity, simplicity, frugality, an unaffected style, Roman thematology, an indifference towards praise and heroic action. Persius' views could be associated with Propertius' latent attack against Tibullus' rusticitas and can be interpreted as disagreement with Propertius' urbanitas. It is possible that in this way Persius expresses his disappointment in the replacement of some elegiac motifs of the past with elegidia and of the frugal, 'poor' Tibullus with the crudi proceres, who are praised in the aula Neroniana. Therefore, the fact that Persius is siding with Tibullus in his dispute with Propertius could suggest a poetic model more similar to his own.
Amphiaraos As Alkman: Compositional Strategy and Mythological Innovation in Pindar's Pythian 8.39-60
Authors:   van 't Wout
Published: January 2006

AbstractIt is argued that Amphiaraos' prophecy in Pindar's eighth Pythian takes place not at the time of the second expedition against Thebes, but at the moment of his heroisation, during the first battle. In the passage leading up to this prophecy, Pindar creates for his audience a listening experience analogous to Amphiaraos' visionary experience, effectuating a fusion of time-layers. In the coda to the speech, it is revealed that this version of the heroisation of Amphiaraos, which centers on the seer's vision of his son Alkman, originates in a vision of Alkman that Pindar himself experienced. Pindar's vision serves as an authoritative source for what appears to be an innovative aspect of the episode.
Ritual Appropriateness in Seven Against Thebes. Civic Religion in a Time of War
Authors: Giordano-Zecharya Manuela 
Published: January 2006

AbstractThis paper explores the themes and tensions of the first part of the Seven Against Thebes, against the background of Athenian civic religion. The confrontation between Eteocles and the Chorus can be seen as an opposition between two gender-related religious attitudes. Eteocles describes his religious behaviour as ritually appropriate whereas he rebukes that of the women as inappropriate and disruptive. Thus, sacrifice and euchê-prayer stand against supplication and lamenting prayer (litê). In partial opposition to other interpretations, this paper views Eteocles as more concerned about the religious behaviour of the Chorus—what they do and how they pray—than with their religious views; in other words he castigates them for their heteropraxy, not their heterodoxy. In the background it is possible to make out the needs of a society of soldier-citizens to contain the ritual and emotional expression of fear and lament in order to avoid demoralizing the troops.
Stanzaic Structure and Responsion in the Elegiac Poetry of Tyrtaeus
Authors: Faraone Christopher 
Published: January 2006

AbstractThis study seeks to revive, defend and further illustrate the suggestion of Weil (1862) (adopted by Rossi (1953/4)) that the longer fragments of Tyrtaeus (nos. 10-12 in West 1992) were composed in five-couplet units (Weil called them 'strophes' but I prefer 'stanzas') that either alternate between exhortation and meditation (e.g. 10.1-30 or 11.1-20) or contrast, for example, the defensive and offensive modes of hoplite warfare (11.21-38), men skilled and unskilled in warfare (12.1-20) or the differing honors that await those war-heroes who die on the battlefield and those who return home alive (12.21-30 and 35-44). These units, moreover, often display a kind of responsion (similar to that found in ancient Greek choral poetry), which allows the poet to draw attention to the stanzaic architecture of the poem and emphasize parallels and contrasts between the individual stanzas. Weil's theory, moreover, provides us with evidence of later re-performances of these poems, especially Tyrtaeus 12, where the transmitted text shows clear signs of a subsequent performance (perhaps in classical Athens as the Platonic paraphrases in the Laws suggest) by a poet who was ignorant or careless of the earlier archaic practice.
Divine intercession in Judah?
Authors: Parker Simon B. 
Published: January 2006

AbstractThe paper explores evidence and reasons for thinking that some Judeans may have believed in and appealed to divine intercessors with Yahweh. After a brief review of the evidence for such a belief and practice outside Judah and in times before and after the Iron Age and Persian period, it considers factors in the social life and religious beliefs of Judeans that would favor such an institution. It then discusses the limited direct evidence for divine intercession, first in biblical literature from the Persian period and then in inscriptions from the Iron Age.
A revisionist reading revisited: On the creation of Adam and then Eve
Authors: Kawashima Robert S. 
Published: January 2006

AbstractThis article consists of two parts. First, I provide a systematic refutation of Phyllis Trible's and Mieke Bal's contention that "the human" created in Gen. ii 7 is a neuter "earth creature" rather than a man. Next, in anticipation of likely objections, I raise certain epistemological questions regarding the nature of interpretation, proposing in the end the position of philosophical realism as a preferable alternative to the "reader-oriented" stance of most current feminist studies (and other so-called ideological approaches). The goal is not to settle this controversy, but to reintroduce a neglected philosophical position into the current debate.
'Ōlāh: the rhetoric of burnt offerings
Authors: Watts James W. 
Published: January 2006

AbstractThe 'ōlāh off ering receives pride of place in most lists of sacrifi ces in the Hebrew Bible, including the ritual rules of Leviticus. Its prominence in these texts suggests that the writers expected its mention to have an eff ect on their audience. This rhetorical eff ect must be evaluated and understood before the references to the 'ōlāh can be used to reconstruct ancient religious practices reliably. A comparative analysis of the rhetoric about the 'ōlāh suggests that its priority burnished the image of priests as devoted selfl essly to divine worship and drew attention away from their economic interests in the sacrifi cial system mandated in the Torah. The eff ect of this rhetoric in later Jewish and Christian traditions was to separate the ideal of "sacrifice" from any necessary connection to actual animal off erings.
Why Edom? On the hostility towards Jacob's brother in prophetic sources
Authors: Assis Elie 
Published: January 2006

AbstractThis contribution offers a new approach to explain the hostile attitude of the biblical sources towards Edom. It is suggested that the relations between Edom and Israel are influenced by the way in which Israel perceived the meaning of the struggle between their fathers—Esau and Jacob. The constant conflict between Edom and Judah may well have been connected by the inhabitants of Judah, consciously or subconsciously, with the conflict between Esau and Jacob over the birthright, and over the control of the promised land. Edom's aspirations to occupy areas in Israel may have been interpreted as Edom's wish to reverse the situation and to restore the election and the birthright to Esau. Following the events in Judah of 587 BCE the people were in despair because they assumed that God had cast off his people forever. They interpreted the destruction of the temple and the expulsion from their land as severance of the relationship between God and his people. The people's exile because of their sins could also be interpreted as the people's loss of their status as the chosen people. Two facts supported their thoughts that they were rejected and Edom was now chosen by God. The first was the Edomite participation in the destruction of Jerusalem and the temple and the expulsion of Judah from their country. And the second was the colonization of the land of Judah by the Edomites. It was not Edom's participation in the destruction or even in the colonization of Judah that led to the exceptional attitude towards Edom in the Biblical sources. The ideological and theological significance that Judah assigned to Edom's acts is what led the prophets to focus on Edom. The anti-Edomite oracles were meant to instil into the hearts of the people that, despite the destruction, Israel is still the chosen people and the sins of Edom against Judah would not remain unpunished.
"Der Herr wird Deinen Eingang und Deinen Ausgang bewahren": Über Herkunft und Fortleben von LXX Psalm cxx 8a
Authors: Kraus Thomas J. 
Published: January 2006

AbstractAmong other differences between the Septuagint (LXX) and Masoretic (MT) version of Psalm cxx / cxxi, its verse 8a contains a peculiar phrasing (την &epsi;&iota;&sigma;o&delta;&oacute;ν &sigma;o&upsi; &kappa;&alpha;&iota;την &epsi;&xi;o&delta;&oacute;ν &sigma;ν&upsi;, "your coming in and your going out"), as the MT has the two nouns in reverse order. In this article I will show that this feature is a unique phenomenon that found its way into the LXX here via a juridical background, where it had already become a fixed common term. A final chapter provides inscriptional evidence for the plain survival of this peculiar phrasing till today. It also makes aware of the fact that in such contexts Psalms obviously were regarded as being open to textual enlargements and changes.
Chicago's "Archaic Mark" (MS 2427): a Reintroduction to Its Enigmas and a Fresh Collation of Its Readings
Authors: Duncan Patricia , Mitchell Margaret 
Published: January 2006

AbstractThis article announces the public release via the Internet of a full set of interactive digital images of the University of Chicago's "Archaic Mark" (Gregory-Aland ms 2427; University of Chicago ms 972), an enigmatic miniature manuscript of the Gospel according to Mark. To foster further research into this curious illuminated hand-codex, we provide a history of research and critical appraisal of the complex questions involved in its dating—which has been placed as early as the 13th century, and as late as the early 20th century—and a fresh collation of its text, which supplements and corrects the readings heretofore available only in the Nestle-Aland 27th edition.
The Special Purim and the Reception of the Book of Esther in the Hellenistic and Early Roman Eras
Authors: Burns Joshua Ezra 
Published: January 2006

AbstractThe current study analyzes evidence of the reception of the book of Esther by Greek-speaking Jewish audiences of the Hellenistic and early Roman periods. The author argues that the book of Esther lent itself to a common mode of cultural recontextualization suggestive of a documented medieval phenomenon known as the Special Purim. The book's inherent appeal to the social mentality of ancient Jewish civilization is demonstrated by tracing the roots of this trend back from the composition of the Hebrew Esther through its later manifestations in Judaea/Palestine and in the Greco-Roman Diaspora.
The Likeness of the Image: Adamic Motifs and Anthropoly in Rabbinic Traditions about Jacob's Image Enthroned in Heaven
Authors: Bunta Silviu 
Published: January 2006

AbstractThe present article analyzes the various texts concerning Jacob's image engraved on the throne of glory. It compares the Jacob texts with previous traditions regarding Adam's special status as the image of God or the equivalent of a cultic representation of an ancient Near Eastern king or of a Roman emperor. The Jacob texts reveal a similar anthropology that emphasizes the dichotomy of humanity. On one hand the earthliness of the functionality of the human body is associated with angelic opposition, and, on the other, the body's divine likeness gives rise to angelic veneration. The investigation of the two traditions demonstrates a conspicuous dependence of the Jacob texts on the Adamic traditions.
Radiotherapy: a novel treatment for pneumothorax
Authors: Ong Y. E. , Sheth A. , Simmonds N. J. , Heenan S. , Allan R. , Glees J. P. , Madden B. P. 
Published: February 2006

Pneumothorax is a relatively common condition that is usually managed either conservatively, by chest tube drainage or, if a refractory air leak persists, then with cardiothoracic intervention. However, there is a small group of patients with a persistent air leak in whom surgical intervention is felt to be inappropriate. This study looks at a novel management strategy in a patient presenting with this scenario.A male with underlying bullous lung disease presented with a right pneumothorax. Complete re-expansion was not achieved, despite chest tube drainage and suction. Cardiothoracic intervention was felt to be inappropriate and the air leak persisted despite prolonged conservative management. Ventilation scintigraphy was therefore used to localise the air leak prior to targeted radiotherapy in an attempt to seal the leakviaradiation-induced fibrosis. Three weeks after the first fraction of radiotherapy, the air leak ceased.In complex cases of pneumothorax with persistent air leak where cardiothoracic intervention is deemed inappropriate, identification of the air leak site and localised radiotherapy could be considered.