bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of different organic selenium supplementations on selenium status and serum biomarkers in dairy cows
Authors: Yang Jinhui , Qian Wentao , Li Hongliang , Wang Menghui , Wei Xiaojun , Li Mingqi , Liu Yang 
Published: March 2024

AbstractThe objective of this study was to investigate the effects of two different organic selenium (Se) supplements, selenomethionine (Se‐Met) and selenohomolanthionine (Se‐Hlan), on the serum biochemical parameters and Se status of dairy cows. Different dietary Se supplementation treatments were set as follows: a control group (CON, adding sodium selenite at 0.3 mg Se/kg dry matter [DM]), 0.3 and 0.5 Se‐Met (adding Se‐Met at 0.3 and 0.5 mg Se/kg DM, respectively), as well as 0.3 and 0.5 Se‐Hlan (adding Se‐Hlan at 0.3 and 0.5 mg Se/kg DM, respectively). The experiment lasted 8 weeks. The serum measurements showed that both organic Se treatments resulted in higher uric acid than CON. Se‐Met produced higher aspartate aminotransferase, glucose, urea, low‐density lipoprotein cholesterol, and lactate dehydrogenase than Se‐Hlan. Regarding the Se status, the highest milk Se values appeared in 0.5 Se‐Met, with intermediate values in 0.3 Se‐Met and 0.5 Se‐Hlan, whereas the highest and lowest serum Se levels were presented in 0.5 Se‐Met and 0.3 Se‐Hlan, respectively. Our results suggest that Se‐Hlan was not as efficient in boosting serum or milk Se as Se‐Met and differences in serum biomarkers between Se‐Met and Se‐Hlan may be associated with distinct metabolic pathways for different forms of organic Se.
Can a “broken heart” successfully be transplanted? A brief report
Authors: Giovannico Lorenzo , Fischetti Giuseppe , Mazzone Federica , Parigino Domenico , Savino Luca , Santeramo Vincenzo , Silva Aline Maria , di Bari Nicola , Acquaviva Tommaso , Fiore Giuseppe , Milano Aldo Domenico , Bottio Tomaso 
Published: March 2024

AbstractA 59‐year‐old woman, with dilated ischemic cardiomyopathy, was urgently admitted to our Intensive Care Unit for cardiogenic shock. ECMO VA was implanted and placed on the national emergency waitlist for transplantation. A potential donation was identified ten days later. The donor was a 58‐year‐old woman, with no cardiovascular risk factors, had died of a rupture of a cerebral aneurysm with left ventricle dysfunction due to Takotsubo syndrome. Brain injuries such as hemorrhage, trauma and stroke have been extensively documented in literature to cause a surge in stress hormones, such as catecholamines. Such a surge can have a direct effect on the heart, resulting in a transient myocardial dysfunction commonly referred to as “Takotsubo cardiomyopathy” or “broken heart syndrome”.Many studies have shown that hearts that are dysfunctional at the start of transplant screening, with normal contractile function at the time of organ retrieval, have similar outcomes to hearts that do not have dysfunction. In our case, the transplanted heart, at the time of sampling, still had moderate dysfunction (EF 40%) which completely disappeared after the transplant.
CAR T therapy from haematological malignancies to aging‐related diseases: An ever‐expanding universe
Authors: Ramoni Davide , Montecucco Fabrizio , Carbone Federico 
Published: March 2024

AbstractBackgroundShort but impactful, the two‐decade story of gene editing allowed a significant breakthrough in the treatment of haematological malignancies. However, despite different generations of chimeric antigen receptor T (CAR T), such a successful therapy has not yet been replicated in solid tumours and non‐oncological diseases.MethodsThis narrative review discusses how CAR T therapy still faces challenges in overcoming the complexity of the solid tumour microenvironment and the concerns that its long‐term activity raises about potential unknown and unpredictable consequences in non‐oncological diseases.ResultsIn the most recent studies, the senolytic potential of CAR T is becoming an exciting field of research. Still, experimental but promising results indeed indicate the clearance of senescent cells as an effective strategy to improve exercise capacity and metabolic dysfunction in physiological ageing, with long‐term therapeutic and preventive effects. However, an effective expansion of a CAR T population requires a lympho‐depleting chemotherapy prior to infusion. While this procedure sounds reasonable for rescue therapy of oncological diseases, it poses genotoxic risks that may not be justified for non‐malignant diseases. Those represent the leading gaps for applying CAR T therapy in non‐oncological diseases.ConclusionMore is expected from current studies on the other classes of CAR cells now under investigation. Engineering NK cells and macrophages are candidates to improve cytotoxic and immunomodulating properties, potentially able to broaden application in solid tumours and non‐oncological diseases. Finally, engineering autologous T cells in old individuals may generate biologically deteriorated CAR T clones with impaired function and unpredictable effects on cytokine release.
Patch exploitation behaviour by a parasitoid of a forest pest: The influence of host cues and intra‐ and interspecific interactions
Authors: Suans Melisa A. , Fischbein Déborah , Corley Juan C. 
Published: March 2024

Abstract
For parasitoids, host foraging is the most significant activity for their reproductive success, as it directly translates into offspring production. Therefore, foraging behaviour and patch‐use decisions by parasitoids still attract research interest, especially when the studied species are biological control agents.
In laboratory conditions, we studied the patch exploitation behaviour of Megarhyssa nortoni (Hymenoptera: Ichneumonidae), a larval–pupal parasitoid of several woodwasps (Hymenoptera: Siricidae), exposed to intra‐ and interspecific interactions.
It is known that M. nortoni females are attracted to the symbiotic fungus carried by its hosts, which support host larval development inside the wood. Additionally, in the introduced range where the species has been released in biocontrol programs aimed at managing invasive Sirex noctilio populations, Megarhyssa nortoni coexists with the egg–larval parasitoid Ibalia leucospoides.
First, we investigated whether host–fungal symbiont cues and direct presence of conspecific females affected patch time allocation and oviposition behaviour of M. nortoni, as both stimuli could provide information on concealed hosts. Second, we studied the influence of prior parasitism by I. leucospoides on patch time allocation decisions and oviposition behaviour.
The main results showed that females modulated their responses to the fungal cues when foraging simultaneously with conspecifics. Also, patch‐leaving tendencies and patch residence times were not affected when females foraged patches previously exploited by I. leucospoides; indeed, they probed these patches more frequently.
Our study contributes to the understanding of patch‐use decisions made by parasitoids and their impact on the biological control of damaging insect populations, particularly in a context of two parasitoid species and one host.
Thermal limits of survival and reproduction depend on stress duration: A case study of Drosophila suzukii
Authors: Ørsted Michael , Willot Quentin , Olsen Andreas Kirk , Kongsgaard Viktor , Overgaard Johannes 
Published: March 2024

AbstractStudies of ectotherm responses to heat extremes often rely on assessing absolute critical limits for heat coma or death (CTmax), however, such single parameter metrics ignore the importance of stress exposure duration. Furthermore, population persistence may be affected at temperatures considerably below CTmax through decreased reproductive output. Here we investigate the relationship between tolerance duration and severity of heat stress across three ecologically relevant life‐history traits (productivity, coma and mortality) using the global agricultural pest Drosophila suzukii. For the first time, we show that for sublethal reproductive traits, tolerance duration decreases exponentially with increasing temperature (R2 > 0.97), thereby extending the Thermal Death Time framework recently developed for mortality and coma. Using field micro‐environmental temperatures, we show how thermal stress can lead to considerable reproductive loss at temperatures with limited heat mortality highlighting the importance of including limits to reproductive performance in ecological studies of heat stress vulnerability.
Classification of recombinant factor VIII products and implications for clinical practice: A systematic literature review
Authors: Ay Cihan , Napolitano Mariasanta , Hassoun Abel , Tomic Radovan , Martin Cedric , Seifert Wilfried , Pinachyan Karen , Oldenburg Johannes 
Published: March 2024

AbstractIntroductionConsensus over the definition of recombinant factor VIII (rFVIII) product classification in haemophilia A is lacking. rFVIII products are often classified as standard half‐life (SHL) or extended half‐life (EHL); despite this, no universally accepted definition currently exists. One proposed definition includes half‐life, area under the curve, and technology designed to extend half‐life; however, the International Society on Thrombosis and Haemostasis defines activity over time as the most intuitive information for building treatment regimens and the World Federation of Hemophilia describes rFVIII product classification in terms of infusion frequency.AimTo summarise published data on the clinical and pharmacokinetic criteria used to define rFVIII product classification.MethodsPubMed and EMBASE database searches of English‐language articles (2002–2022) were conducted using search strings to identify the relevant population, intervention, and outcomes (e.g., clinical and pharmacokinetic parameters). Articles then underwent title/abstract and full‐text screens.ResultsAmong 1147 identified articles, 62 were included. Half‐life was the most widely reported outcome with no clear trends or product groupings observed. No clear groupings emerged among other outcomes, including infusion frequency, consumption, and efficacy. As activity over time was reported in few articles, further investigation of its relevance to rFVIII product classification is warranted.ConclusionThe findings of this systematic literature review suggest that parameters other than half‐life might be important for the development of a comprehensive and clinically relevant rFVIII product classification definition. There seems to be an opportunity to consider parameters that are clinically meaningful and useful for shared decision‐making in haemophilia A treatment.
Inhibitory effect of ginger juice on the formation of advanced glycation end products in fried fish cakes
Authors: Gao Yanlei , Shi Haonan , Xiong Qing , Rong Jianhua , Liu Ru 
Published: March 2024

SummaryThe impact of different ginger juice ratios on the formation of advanced glycation end products (AGEs) in fried fish cakes was examined. The consequences confirmed that the AGEs mainly gathered in the crust layer. Ginger juice has a good oil‐reducing and water‐retaining effect on fried cakes. Ginger juice demonstrated a remarkable capacity to diminish the AGEs content, particularly when utilised at a ratio of 5%. It led to a decrease of around 20% in the fat content and 11% in the thiobarbituric acid (TBARS) value for the crust. Meanwhile, when incorporating 5% ginger juice into cakes, an improvement in sensory attributes, a compact microstructure, elevated moisture levels and reduced pH values was observed. Therefore, the addition of an appropriate amount of ginger juice could efficiently inhibit the generation of AGEs, all the while preserving the exceptional characteristics and sensory attributes of fried cakes.
Cumulative environmental stress and emerging cardiometabolic risk during childhood
Authors: Kunin‐Batson Alicia S. , Haapala Jacob , Crain A. Lauren , Gunnar Megan R. , Kharbanda Elyse O. , Kelly Aaron S. , Seburg Elisabeth M. , Sherwood Nancy E. , French Simone A. 
Published: March 2024

SummaryObjectiveTo prospectively evaluate the relationship between cumulative environmental stress and cardiometabolic risk in middle childhood, and to examine whether hair cortisol, a measure of hypothalamic pituitary adrenal‐axis activity, mediates this relationship.MethodsIn a cohort of children from low‐income households (n = 320; 59% Hispanic, 23% Black, body mass index (BMI) percentile >50th at enrollment), environmental stressors including family and neighbourhood factors representing disadvantage/deprivation, and cortisol concentrations from hair samples, were measured over five timepoints beginning when children were 2–4 years old. Cardiometabolic risk factors (i.e., BMI, blood pressure, lipids, blood sugar, C‐reactive protein) were measured at the final timepoint when children were 7–11 years of age.ResultsIn adjusted logistic regression models, greater cumulative environmental stress was associated with a higher likelihood of elevated cardiometabolic risk in middle childhood (p = 0.01). Children from minoritized racial/ethnic groups had a higher prevalence of both stressors and cardiometabolic risk factors. Cumulative environmental stress was associated with higher hair cortisol concentrations (p < 0.01). However, hair cortisol was not directly associated with cardiometabolic risk factors and did not explain the association between environmental stress and cardiometabolic risk in causal mediation analysis.ConclusionsThe influence of cumulative stress on cardiometabolic health can be observed in middle childhood and may contribute to cardiometabolic health disparities, highlighting the importance of public health interventions to mitigate disadvantage.
RNAi‐mediated knockdown of exportin 1 negatively affected ovary development, survival and maize mosaic virus accumulation in its insect vector Peregrinus maidis
Authors: Xavier Cesar A. D. , Tyson Clara , Kerner Leo M. , Whitfield Anna E. 
Published: March 2024

AbstractExportin 1 (XPO1) is the major karyopherin‐β nuclear receptor mediating the nuclear export of hundreds of proteins and some classes of RNA and regulates several critical processes in the cell, including cell‐cycle progression, transcription and translation. Viruses have co‐opted XPO1 to promote nucleocytoplasmic transport of viral proteins and RNA. Maize mosaic virus (MMV) is a plant‐infecting rhabdovirus transmitted in a circulative propagative manner by the corn planthopper, Peregrinus maidis. MMV replicates in the nucleus of plant and insect hosts, and it remains unknown whether MMV co‐opts P. maidis XPO1 (PmXPO1) to complete its life cycle. Because XPO1 plays multiple regulatory roles in cell functions and virus infection, we hypothesized that RNAi‐mediated silencing of XPO1 would negatively affect MMV accumulation and insect physiology. Although PmXPO1 expression was not modulated during MMV infection, PmXPO1 knockdown negatively affected MMV accumulation in P. maidis at 12 and 15 days after microinjection. Likewise, PmXPO1 knockdown negatively affected P. maidis survival and reproduction. PmXPO1 exhibited tissue‐specific expression patterns with higher expression in the ovaries compared with the guts of adult females. Survival rate was significantly lower for PmXPO1 knockdown females, compared with controls, but no effect was observed for males. PmXPO1 knockdown experiments revealed a role for PmXPO1 in ovary function and egg production. Oviposition and egg hatch on plants were dramatically reduced in females treated with dsRNA PmXPO1. These results suggest that PmXPO1 is a positive regulator of P. maidis reproduction and that it plays a proviral role in the insect vector supporting MMV infection.
Expanding records of occurrence of the whale shark (Rhincodon typus) in The Bahamas and a call for sustainable tourism practices
Authors: Wosnick Natascha , Schneider Eric V. C. 
Published: March 2024

AbstractThis report updates our understanding of whale shark occurrences in The Bahamas by drawing upon a variety of data sources. Our findings reveal previously unreported sighting locations, often associated with tourism activities, underscoring the pivotal role played by nontraditional data sources in addressing knowledge gaps. These revelations emphasize the ongoing necessity for monitoring efforts. Additionally, we have found cases that raise concerns related to unregulated human–shark interactions in the region, highlighting the pressing need for sustainable tourism practices within Bahamian waters.
V‐EMF therapy: A new painless and completely non‐invasive treatment for striae gravidarum
Authors: Veronese Sheila , Bacci Pier Antonio , Garcia‐Gimenez Victor , Canel Micheloud Casiana Cecilia , Haro García Norma Laura , Sbarbati Andrea 
Published: March 2024

AbstractBackgroundThe appearance of striae gravidarum (SG) during pregnancy is a common problem. The most common SG are abdominal striae, which can cause the greatest sequelae after pregnancy, and in the long term. There are several solutions to prevent and treat these striae, but not all are completely effective, and not without side effects.AimsThe aim of this study was to evaluate the effectiveness of a treatment that applies an electromagnetic field under vacuum (V‐EMF therapy) on the abdominal SG.MethodsA retrospective analysis was conducted on the medical records of 26 women affected by abdominal SG and treated with V‐EMF therapy. The results were evaluated using two different 5‐point Likert Scales: one administered to the treated subjects to evaluate their satisfaction, and one to the doctors who performed the treatment, to evaluate the improvement of the striae. The presence of side effects, and the effects of sun exposure after treatment were also considered.ResultsOnly two treated subjects rated their level of satisfaction with a Score III on the Liker Scale. Everyone else expressed higher levels of satisfaction. Only one doctor rated the improvement of the striae with a Liker scale score of III. All the others reported greater improvements. No discomfort or side effects were noted either during the individual treatment sessions, or at the end of the treatment. The striae showed a newfound ability to tan.ConclusionsV‐EMF therapy proves to be a valid, safe, and effective treatment modality for SG.
3‐methyl‐1H‐indol‐1‐yl dimethylcarbamodithioate attenuates periodontitis through targeting MAPK signaling pathway‐regulated mitochondrial function
Authors: Jiang Yun , Ren Xuekun , Mao Jiajie , Zeng Jun , Jiang Wanying , Zhou Runqi , Han Yue , Wang Hongning , Mao Yixin , Sun Xiaoyu , Cao Zelin , Song Zengqiang , Huang Shengbin , Zhao Shufan 
Published: March 2024

AbstractPeriodontitis, the second most common oral disease, is primarily initiated by inflammatory responses and osteoclast differentiation, in which the MAPK signaling pathway and mitochondrial function play important roles. 3‐methyl‐1H‐indol‐1‐yl dimethylcarbamodithioate (3o), a hybrid of indole and dithiocarbamate, was first synthesized by our group. It has shown anti‐inflammatory activity against lipopolysaccharide‐induced acute lung injury. However, it is not known if 3o can exert effects in periodontitis. In vitro study: LPS‐induced macrophage inflammation initiation and a receptor activator of nuclear factor κB ligand‐stimulated osteoclast differentiation model were established. Cell viability, inflammatory cytokines, osteoclast differentiation, the MAPK signaling pathway, and mitochondrial function before and after treatment with 3o were investigated. In vivo study: Alveolar bone resorption, inflammatory cytokine expression, osteoclast differentiation, and the underlying mechanisms were assessed in mice with periodontitis. Inflammatory cytokine expression and osteoclast differentiation appeared downregulated after 3o treatment. 3o inhibited the MAPK signaling pathway and restored mitochondrial function, including mitochondrial reactive oxygen species, mitochondrial membrane potential, and ATP production. Meanwhile, 3o reduced inflammation activation and bone resorption in mice with periodontitis, reflected by the decreased expression of inflammatory cytokines and osteoclasts, implying that 3o inhibited the MAPK signaling pathway and the mitochondrial oxidative DNA damage marker 8‐OHdG. These results highlight the protective role of 3o in periodontitis in mice and reveal an important strategy for preventing periodontitis.
How Do Parents Choose Schools for Their Children? Experimental Evidence from the Private Christian School Sector
Authors: Lee Matthew H. , Johnson Alison , Cheng Albert 
Published: March 2024

AbstractResearch documents that nearly all parents of school‐aged children in the general U.S. population strongly consider academic quality when choosing a school for their children. Many of these parents also prefer a religious setting for their children's education. However, little is known about how these school characteristics affect the stated preferences of parents of children in private faith‐based schools. We conducted a conjoint experiment in which we presented 2474 parents in the private Christian school sector with three sets of three hypothetical schools, randomly varying each school's tuition level and the quality of academics, spiritual formation, and extracurricular opportunities. We found that lower quality spiritual formation and academic offerings substantially reduce the likelihood a school will be selected by about 30 percentage points. The quality of extracurricular opportunities and tuition levels influence the likelihood a school will be selected to a lesser degree—about 11 percentage points.
Event Boundaries Stretched and Compressed by Aspect: Temporal Segmentation in a First and a Second Language
Authors: Vanek Norbert , Zhang Haoruo 
Published: March 2024

AbstractEvent segmentation tests have shown substantial overlaps in how adults recognize starts and endpoints as events unfold. However, far less is known about what role different language systems play in the process. Variations in grammatical aspect have been shown to influence event processing. We tested how closely first language (L1) speakers of Mandarin and English versus Mandarin learners of English as a second language (L2) align event boundaries with event‐internal changes. We used two event boundary marking tasks (online/offline) and a sorting task. Participants saw 60 animations; their task was to indicate starts and endpoints. For punctual events (e.g., breaking a wall), Mandarin L1 speakers and Mandarin learners of English L2 were significantly further from event transitions than English L1 speakers. This pattern was replicated in the untimed experiment but not in sorting transitions, jointly suggesting that Mandarin L1 and Mandarin learners of English L2 may be less attentive to segmentation of phases surrounding transitions than English L1 speakers. We argue that this variation reflects L1‐specific encoding of ongoingness.
Awakening the Proto‐Lexicon: A Proto‐Lexicon Gives Learning Advantages for Intentionally Learning a Language
Authors: Mattingley Wakayo , Panther Forrest , Todd Simon , King Jeanette , Hay Jennifer , Keegan Peter J. 
Published: March 2024

AbstractPrevious studies report that exposure to the Māori language on a regular basis allows New Zealand adults who cannot speak Māori to build a proto‐lexicon of Māori—an implicit memory of word forms without detailed knowledge of meaning. How might this knowledge feed into explicit language learning? Is it possible to “awaken” the proto‐lexicon in the context of overt language learning? We investigate whether implicit linguistic knowledge represented in a proto‐lexicon gives any advantages for intentional language learning in a tertiary educational environment. We conducted a three‐task experiment which: (a) assessed participants’ Māori proto‐lexicon, (b) assessed their phonotactic knowledge, and (c) tested them on Māori vocabulary that they had been exposed to during the course at two time points. The results show that students with larger Māori proto‐lexicons learn more words in a classroom setting. This study shows that proto‐lexicon acquired from ambient exposure can lead to significant benefits in language learning.