bluuebunny/crossref_metadata_2025_split huggingface dataset:
The DCI index: Discounted cumulated impact‐based research evaluation
Authors: Järvelin Kalervo , Persson Olle 
Published: May 2008

AbstractResearch evaluation is increasingly popular and important among research funding bodies and science policy makers. Various indicators have been proposed to evaluate the standing of individual scientists, institutions, journals, or countries. A simple and popular one among the indicators is the h‐index, the Hirsch index (Hirsch 2005), which is an indicator for lifetime achievement of a scholar. Several other indicators have been proposed to complement or balance the h‐index. However, these indicators have no conception of aging. The AR‐index (Jin et al. 2007) incorporates aging but divides the received citation counts by the raw age of the publication. Consequently, the decay of a publication is very steep and insensitive to disciplinary differences. In addition, we believe that a publication becomes outdated only when it is no longer cited, not because of its age. Finally, all indicators treat citations as equally material when one might reasonably think that a citation from a heavily cited publication should weigh more than a citation froma non‐cited or little‐cited publication.We propose a new indicator, the Discounted Cumulated Impact (DCI) index, which devalues old citations in a smooth way. It rewards an author for receiving new citations even if the publication is old. Further, it allows weighting of the citations by the citation weight of the citing publication. DCI can be used to calculate research performance on the basis of the h‐core of a scholar or any other publication data set. Finally, it supports comparing research performance to the average performance in the domain and across domains as well.
Using field cocitation analysis to assess reciprocal and shared impact of LIS/MIS fields
Authors: Sugimoto Cassidy R. , Pratt Jean A. , Hauser Karina 
Published: May 2008

AbstractThis study utilized bibliometric tools to analyze the relationship between two separate, but related, fields: Library and Information Science (LIS) and Management Information Systems (MIS). The top‐ranked 48 journals in each field were used as the unit of analysis. Using these journals, field cocitation was introduced as a method for evaluating the relationships between the two fields. The three‐phased study evaluated (a) the knowledge imported/exported between LIS and MIS, (b) the body of knowledge influenced by both fields, and (c) the overlap in fields as demonstrated by multidimensional scaling. Data collection and analysis were performed using DIALOG and SPSS programs. The primary findings from this study indicate that (a) the MIS impact on LIS is greater than the reverse, (b) there is a growing trend for shared impact between the two disciplines, and (c) the area of overlap between the two fields is predominately those journals focusing on technology systems and digital information. Additionally, this study validated field cocitation as a method by which to evaluate relationships between fields.
Tryptophan catabolites in mesenteric lymph may contribute to pancreatitis-associated organ failure
Authors: Mole D J , McFerran N V , Collett G , O'Neill C , Diamond T , Garden O J , Kylanpaa L , Repo H , Deitch E A 
Published: May 2008

Abstract

Background
Multiple organ failure (MOF) is the key determinant of mortality in acute pancreatitis (AP). Mesenteric lymph cytotoxicity contributes to organ failure in experimental models of systemic inflammation. The aim of this study was to evaluate the mesenteric lymph pathway and the lymph injury proteome in experimental AP-associated MOF, and to test the hypothesis that immunoregulatory tryptophan catabolites contribute to mesenteric lymph cytotoxicity.

Methods
Using an experimental model of AP in rats, the humoral component of mesenteric lymph in AP was compared with that from sham-operated control animals, using in vitro and in vivo cytotoxicity assays, high-throughput proteomics and high-performance liquid chromatography. The experimental findings were corroborated in a cohort of 34 patients with AP.

Results
Compared with biologically inactive lymph from sham-operated rats, mesenteric lymph in AP became cytotoxic 3 h after induction. Hierarchical clustering of lymph proteomic mass spectra predicted the biological behaviour of lymph. Levels of the immunoregulatory tryptophan catabolite, 3-hydroxykynurenine, were increased in cytotoxic lymph and re-created cytotoxicity in vitro. In humans with AP, plasma kynurenine concentrations correlated in real time with MOF scores and preceded a requirement for mechanical ventilation and haemodialysis.

Conclusion
These results support the concept that mesenteric lymph-borne kynurenines may contribute to pancreatitis-associated MOF.
Relationship Between Lipoprotein(a) and Spontaneous Recanalization of Infarct‐related Arteries in the Early Phase of Acute Myocardial Infarction
Authors: Kim Jin Won , Seo Hong Seog , Suh Soon Yong , Choi Cheol Ung , Kim Eung Ju , Rha Seung‐Woon , Park Chang Gyu , Oh Dong Joo 
Published: May 2008

AbstractBackgroundLipoprotein(a) (Lp[a]) is known to inhibit the fibrinolysis system and promote thrombus formation.HypothesisWe retrospectively investigated the influences of Lp(a) on infarct‐related artery patency in the early phase of acute myocardial infarction (AMI).MethodsIn 144 patients with ST‐segment elevation, myocardial, coronary angiography (CAG) was performed within 12 h of the onset of symptoms. Subjects were divided into 2 groups according to the thrombolysis in myocardial infaction (TIMI) grade, Group I (TIMI 0–1, n = 94) versus Group II (TIMI 2–3, n = 50). The Gensini score and 0‐ to 3‐vessel disease score estimated the severity and extent of coronary artery disease (CAD), respectively. Lp(a), lipid profile and c‐reactive protein (CRP) were measured before any medications including thrombolytics were given.ResultsThe Lp(a) level was higher in Group I than in Group II. There was a weak correlation between Lp(a) level and Gensini score. By multivariate logistic regression analysis, a Lp(a) level was a predictor of infarct‐related artery patency in the early phase of AMI. There were no significant differences in the location of the infarct‐related arteries, extent of CAD, time from pain to CAG, number of risk factors, and hs‐CRP values between the 2 groups.ConclusionThe Lp(a) level was significantly higher in patients with persistent occlusion compared with those with spontaneous recanalization of infarct‐related arteries in the early phase of AMI. Copyright © 2008 Wiley Periodicals, Inc.
High mobility group AT‐hook 1 (HMGA1) is an independent prognostic factor and novel therapeutic target in pancreatic adenocarcinoma
Authors: Liau Siong‐Seng , Rocha Flavio , Matros Evan , Redston Mark , Whang Edward 
Published: May 2008

AbstractBACKGROUND.High mobility group AT‐hook 1 (HMGA1) proteins are architectural transcription factors that are overexpressed by pancreatic adenocarcinomas. The authors hypothesized that tumor HMGA1 status represents a novel prognostic marker in pancreatic adenocarcinoma. They also tested the hypothesis that HMGA1 promotes anchorage‐independent cellular proliferation and in vivo tumorigenicity.METHODS.Tumor HMGA1 expression was examined by immunohistochemical analysis of tissues from 89 consecutive patients who underwent resection for pancreatic adenocarcinoma. Short‐hairpin RNA (shRNA)‐mediated RNA interference was used to silence HMGA1 expression in MiaPaCa2 and PANC1 pancreatic cancer cells. Anchorage‐independent proliferation was assessed by using soft agar assays. The roles of phosphatidylinositol 3‐kinase (PI3‐K)/Akt and extracellular signal‐regulated kinase (ERK) signaling were investigated by using specific inhibitors and adenoviral dominant‐negative/active Akt constructs. In vivo tumorigenicity was assessed by using a nude mouse xenograft model.RESULTS.Tumor HMGA1 expression was detected in 93% of patients with pancreatic adenocarcinoma. Patients with HMGA1‐negative tumors had a significantly longer median survival than patients with HMGA1‐expressing cancers in univariate analysis (P = .0028) and in multivariate analysis (P<.05). shRNA‐mediated HMGA1 silencing resulted in significant reductions in anchorage‐independent proliferation in soft agar. Forced HMGA1 overexpression promoted proliferation in soft agar through a process that was dependent on PI3‐K/Akt‐activited signaling, but not on mitogen‐activated protein kinase (MEK)/ERK signaling. Targeted silencing of HMGA1 reduced tumor growth in vivo through reduced proliferation (Ki‐67 index) and increased apoptosis (terminal deoxynucleotidyl transferase nick‐end labeling).CONCLUSIONS.The current findings suggested that HMGA1 is an independent predictor of poor postoperative survival in patients with pancreatic adenocarcinoma. Furthermore, HMGA1 promotes tumorigenicity through a PI3‐K/Akt‐dependent mechanism. HMGA1 warrants further evaluation as a prognostic marker and therapeutic target in pancreatic cancer. Cancer 2008. © 2008 American Cancer Society.
Cancer screening practices of adult survivors of retinoblastoma at risk of second cancers
Authors: Sheen Victoria , Tucker Margaret A. , Abramson David H. , Seddon Johanna M. , Kleinerman Ruth A. 
Published: May 2008

AbstractBACKGROUND.The aim of the current study was to investigate the pattern of cancer screening behavior in adult retinoblastoma survivors, who are at high risk of developing second cancers.METHODS.Self‐reported cancer screening practices were investigated in a cohort of retinoblastoma survivors to evaluate whether they were receiving adequate screening for specific cancers and compare these rates with those of other adult survivors of childhood cancer and the general population. The prevalence of breast self‐examination, clinical breast examination, mammography, Papanicolaou (Pap) test, testicular self‐examination, and magnetic resonance imaging (MRI) or computed tomography (CT) scanning was determined from computer‐aided telephone interviews with 836 retinoblastoma survivors aged >18 years.RESULTS.Among female survivors, 87% had a Pap test within the past 2 years, and 76% of females age >40 years reported having a mammogram within the past 2 years; 17.4% of male survivors had performed monthly testicular self‐examinations. A significantly higher proportion of hereditary compared with nonhereditary survivors reported having undergone an MRI or CT scan in the past 5 years. Higher education, greater contact with the medical care system, and having a second cancer were found to be associated positively with most screening practices. Cancer screening practices reported by retinoblastoma survivors were similar to national screening rates for breast, cervical, and testicular cancer.CONCLUSIONS.To the authors' knowledge, the current study provides the first report of cancer screening practices of retinoblastoma survivors. Survivors of hereditary retinoblastoma should be encouraged to maintain, if not increase, their current screening practices to ensure early detection of second cancers in this high‐risk population. Cancer 2008. © 2008 American Cancer Society.
Long‐term course of binge eating disorder and bulimia nervosa: Relevance for nosology and diagnostic criteria
Authors: Fichter Manfred M. , Quadflieg Norbert , Hedlund Susanne 
Published: May 2008

AbstractObjective:To present the twelve‐year outcome of binge eating disorder (BED) in 68 female inpatients compared to bulimia nervosa, purging type (BN‐P; N = 196).Method:Self and expert ratings focused on the beginning of therapy and the 12‐year follow‐up.Results:36% of BED and 28.2% of BN‐P patients still received an eating disorder diagnosis at follow‐up. Differences between groups were small (Eating Disorder Inventory, Structured Inventory for Anorexic and Bulimic Syndromes, Hopkins Symptom Checklist, Beck Depression Inventory). Similar predictors for BED and BN‐P were identified. Psychiatric comorbidity was the predominant predictor of poor outcome in both diagnoses. Predictors for BED outcome were body dissatisfaction, sexual abuse, and impulsivity; self‐injury predicted BN‐P outcome.Conclusion:Course, outcome, and mortality were similar for BED and BN‐P. Both disorders had psychiatric comorbidity as the main predictor of outcome, and there was a diagnostic shift between BED and BN‐P over time, pointing to their nosological proximity. Data are relevant for the formulation of DSM‐V and ICD‐11 diagnostic criteria. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2008
Analysis of polygonal terrain landforms on Earth and Mars through spatial point patterns
Authors: Dutilleul Pierre , Haltigin Timothy W. , Pollard Wayne H. 
Published: May 2008

AbstractIn this paper, we explain the successive steps by which spatial point pattern analysis (SPPA) can be used to describe the variety of polygonal terrain morphologies observed both on Earth and on Mars. In this context, a point is defined as a polygon trough intersection with identifiable spatial coordinates. This definition corresponds to a key step in our approach: obtaining observed 2‐D spatial point patterns from digitized images. The distribution of nearest‐neighbor (NN) distances provides the quantitative basis sought to characterize objectively the overall polygonal network geometry as completely random, regular, or intermediate. In the cases of regular geometry, the distribution of NN distances can be advantageously modeled, which completes the effectiveness of the statistical approach and method based on SPPA. Copyright © 2008 John Wiley & Sons, Ltd.
Tests for gene‐environment interaction from case‐control data: a novel study of type I error, power and designs
Authors: Mukherjee Bhramar , Ahn Jaeil , Gruber Stephen B. , Rennert Gad , Moreno Victor , Chatterjee Nilanjan 
Published: May 2008

AbstractTo evaluate the risk of a disease associated with the joint effects of genetic susceptibility and environmental exposures, epidemiologic researchers often test for non‐multiplicative gene‐environment effects from case‐control studies. In this article, we present a comparative study of four alternative tests for interactions: (i) the standard case‐control method; (ii) the case‐only method, which requires an assumption of gene‐environment independence for the underlying population; (iii) a two‐step method that decides between the case‐only and case‐control estimators depending on a statistical test for the gene‐environment independence assumption and (iv) a novel empirical‐Bayes (EB) method that combines the case‐control and case‐only estimators depending on the sample size and strength of the gene‐environment association in the data. We evaluate the methods in terms of integrated Type I error and power, averaged with respect to varying scenarios for gene‐environment association that are likely to appear in practice. These unique studies suggest that the novel EB procedure overall is a promising approach for detection of gene‐environment interactions from case‐control studies. In particular, the EB procedure, unlike the case‐only or two‐step methods, can closely maintain a desired Type I error under realistic scenarios of gene‐environment dependence and yet can be substantially more powerful than the traditional case‐control analysis when the gene‐environment independence assumption is satisfied, exactly or approximately. Our studies also reveal potential utility of some non‐traditional case‐control designs that samples controls at a smaller rate than the cases. Apart from the simulation studies, we also illustrate the different methods by analyzing interactions of two commonly studied genes, N‐acetyl transferase type 2 and glutathione s‐transferase M1, with smoking and dietary exposures, in a large case‐control study of colorectal cancer. Genet. Epidemiol. 2008. Published 2008 Wiley‐Liss, Inc.
Ordered‐subset analysis (OSA) for family‐based association mapping of complex traits
Authors: Chung Ren‐Hua , Schmidt Silke , Martin Eden R. , Hauser Elizabeth R. 
Published: May 2008

AbstractAssociation analysis provides a powerful tool for complex disease gene mapping. However, in the presence of genetic heterogeneity, the power for association analysis can be low since only a fraction of the collected families may carry a specific disease susceptibility allele. Ordered‐subset analysis (OSA) is a linkage test that can be powerful in the presence of genetic heterogeneity. OSA uses trait‐related covariates to identify a subset of families that provide the most evidence for linkage. A similar strategy applied to genetic association analysis would likely result in increased power to detect association. Association in the presence of linkage (APL) is a family‐based association test (FBAT) for nuclear families with multiple affected siblings that properly infers missing parental genotypes when linkage is present. We propose here APL‐OSA, which applies the OSA method to the APL statistic to identify a subset of families that provide the most evidence for association. A permutation procedure is used to approximate the distribution of the APL‐OSA statistic under the null hypothesis that there is no relationship between the family‐specific covariate and the family‐specific evidence for allelic association. We performed a comprehensive simulation study to verify that APL‐OSA has the correct type I error rate under the null hypothesis. This simulation study also showed that APL‐OSA can increase power relative to other commonly used association tests (APL, FBAT and FBAT with covariate adjustment) in the presence of genetic heterogeneity. Finally, we applied APL‐OSA to a family study of age‐related macular degeneration, where cigarette smoking was used as a covariate. Genet. Epidemiol. 2008. © 2008 Wiley‐Liss, Inc.
Does advanced medical technology encourage hospitalist use and their direct employment by hospitals?
Authors: David Guy , Helmchen Lorens A. , Henderson Robert A. 
Published: May 2008

AbstractIn the United States, inpatient medical care increasingly encompasses the use of expensive medical technology and, at the same time, is coordinated and supervised more and more by a rapidly growing number of inpatient‐dedicated physicians (hospitalists). In the production of inpatient care services, Hospitalist services can be viewed as complementary to sophisticated and expensive medical equipment in the provision of inpatient medical care. We investigate the causal relationship between a hospital's access to three types of sophisticated diagnostic and therapeutic medical equipment – intensity‐modulated radiation therapy, gamma knife, and multi‐slice computed tomography – and its likelihood of using hospitalists. To rule out omitted variables bias and reverse causality, we use technology‐specific Certificate of Need regulation to predict technology use. We find a strong positive association, yet no causal link between access to medical technology and hospitalist use. We also study the choice of employment modality among hospitals that use hospitalists, and find that access to expensive medical technology reduces the hospital's propensity to employ hospitalists directly. Copyright © 2008 John Wiley & Sons, Ltd.
Theoretical characterizations of HAsXH (X = N, P, As, Sb, and Bi) isomers in the singlet and triplet states
Authors: Lai Chin‐Hung , Su Ming‐Der 
Published: May 2008

AbstractThe lowest singlet and triplet potential energy surfaces for all group 15 HAsXH (X = N, P, As, Sb, and Bi) systems have been explored through ab initio calculations. The geometries of the various isomers were determined at the QCISD/LANL2DZdp level and confirmed to be minima by vibrational analysis. In the case of nitrogen, the global minimum is found to be a triplet H2NAs structure. For the phosphorus case, singlet trans‐HAsPH is found to be global minima surrounded by large activation barriers, so that it should be observable. For arsenic, theoretical investigations demonstrate that the stability of HAsAsH isomers decreases in the order singlet trans‐HAsAsH > triplet H2AsAs > singlet cis‐HAsAsH > triplet HAsAsH > singlet H2AsAs. For antimony and bismuth, the theoretical findings suggest that the stability of HAsXH (X = Sb and Bi) systems decreases in the order triplet H2AsX ≈ singlet trans‐HAsXH > singlet cis‐HAsXH > triplet HAsXH > triplet H2XAs > singlet H2AsX > singlet H2XAs. Our model calculations indicate that the relativistic effect on heavier group 15 elements should play an important role in determining the geometries as well as the stability of HAsXH molecules. The results obtained are in good agreement with the available experimental data and allow a number of predictions to be made. © 2008 Wiley Periodicals, Inc. J Comput Chem, 2008
QM/MM vibrational mode tracking
Authors: Herrmann Carmen , Neugebauer Johannes , Reiher Markus 
Published: May 2008

AbstractVibrational spectroscopy is a powerful tool to investigate the structure and dynamics of biomolecules. When small subsystems of large molecules such as active centers of enzymes are studied, quantum chemical calculations based on quantum mechanics/molecular mechanics (QM/MM) coupling schemes are a valuable means to interpret the spectra. The goal of this work is a methodological pilot study on how to selectively and thus efficiently extract certain vibrational information for extended molecular systems described by QM/MM methods. This is achieved by an extension of the mode tracking algorithm and a comparison with the partial Hessian diagonalization approach. After validating the methodology for the CO stretching vibration of 2‐butanone and a delocalized CO stretch in acetylacetone, the stretching and bending modes of the CO ligand in CO myoglobin are tracked. Such systems represent an ideal application for mode tracking, because only a few strongly localized vibrations are sought for, while the large remainder of the molecule is of interest only as far as it affects these local vibrations. This influence is treated exactly by mode tracking. © 2008 Wiley Periodicals, Inc. J Comput Chem, 2008
Rational emotive behavior therapy, cognitive therapy, and medication in the treatment of major depressive disorder: a randomized clinical trial, posttreatment outcomes, and six‐month follow‐up
Authors: David Daniel , Szentagotai Aurora , Lupu Viorel , Cosman Doina 
Published: May 2008

AbstractA randomized clinical trial was undertaken to investigate the relative efficacy of rational‐emotive behavior therapy (REBT), cognitive therapy (CT), and pharmacotherapy in the treatment of 170 outpatients with nonpsychotic major depressive disorder. The patients were randomly assigned to one of the following: 14 weeks of REBT, 14 weeks of CT, or 14 weeks of pharmacotherapy (fluoxetine). The outcome measures used were the Hamilton Rating Scale for Depression and the Beck Depression Inventory. No differences among treatment conditions at posttest were observed. A larger effect of REBT (significant) and CT (nonsignificant) over pharmacotherapy at 6 months follow‐up was noted on the Hamilton Rating Scale for Depression only. © 2008 Wiley Periodicals, Inc. J Clin Psychol 64:728‐746, 2008.