bluuebunny/crossref_metadata_2025_split huggingface dataset:
tiRNA‐Gly‐GCC‐001 in major depressive disorder: Promising diagnostic and therapeutic biomarker
Authors: Tian Haihua , Gao Shugui , Xu Miaomiao , Yang Mei , Shen Mengyuan , Liu Jimeng , Li Guangxue , Zhuang Dingding , Hu Zhenyu , Wang Chuang 
Published: March 2024

AbstractBackground and PurposeIn major depressive disorder (MDD), exploration of biomarkers will be helpful in diagnosing the disorder as well as in choosing a treatment and predicting the treatment response. Currently, tRNA‐derived small ribonucleic acids (tsRNAs) have been established as promising non‐invasive biomarker candidates that may enable a more reliable diagnosis or monitoring of various diseases. Herein, we aimed to explore tsRNA expression together with functional activities in MDD development.Experimental ApproachSerum samples were obtained from patients with MDD and healthy controls, and small RNA sequencing (RNA‐Seq) was used to profile tsRNA expression. Dysregulated tsRNAs in MDD were validated by quantitative real‐time polymerase chain reaction (qRT‐PCR). The diagnostic utility of specific tsRNAs and the expression of these tsRNAs after antidepressant treatment were analysed.Key ResultsIn total, 38 tsRNAs were significantly differentially expressed in MDD samples relative to healthy individuals (34 up‐regulated and 4 down‐regulated). qRT‐PCR was used to validate the expression of six tsRNAs that were up‐regulated in MDD (tiRNA‐1:20‐chrM.Ser‐GCT, tiRNA‐1:33‐Gly‐GCC‐1, tRF‐1:22‐chrM.Ser‐GCT, tRF‐1:31‐Ala‐AGC‐4‐M6, tRF‐1:31‐Pro‐TGG‐2 and tRF‐1:32‐chrM.Gln‐TTG). Interestingly, serum tiRNA‐Gly‐GCC‐001 levels exhibited an area under the ROC curve of 0.844. Moreover, tiRNA‐Gly‐GCC‐001 is predicted to suppress brain‐derived neurotrophic factor (BDNF) expression. Furthermore, significant tiRNA‐Gly‐GCC‐001 down‐regulation was evident following an 8‐week treatment course and served as a promising baseline predictor of patient response to antidepressant therapy.Conclusion and ImplicationsOur current work reports for the first time that tiRNA‐Gly‐GCC‐001 is a promising MDD biomarker candidate that can predict patient responses to antidepressant therapy.
Architecture and evolution of shelf‐margin clinoforms developed in a back‐arc tectonic setting: Insights from quantitative analysis on the south‐west shelf margin of the Ulleung Basin
Authors: Song Gihun , Lee Hyun Suk , Lee Seungcheol 
Published: March 2024

AbstractGeophysical and geological research in the Ulleung Basin has been ongoing since the 1970s, involving continuous seismic acquisition and multiple well‐drilling projects. This study utilized an integrated quantitative approach with conventional seismic interpretation based on recent trends to understand the history of the shelf‐margin development and individual controls that may have influenced each period in the Ulleung Basin. Quantitative analysis was conducted by measuring the progradation (Pse), aggradation (Ase) and sediment influx (Fc) of individual shelf margins in seven dip‐oriented seismic profiles, and calculating the shelf‐edge gradient (αse) and the P/A ratio. Based on these data and the ratio of accommodation to sediment supply (A/S ratio), which was interpreted from the stratal stacking pattern, five shelf‐edge trajectory types were defined and assigned to each shelf margin. By considering individual controls (eustatic fluctuations, sediment supply and tectonic events), we defined the three evolution intervals of the Ulleung Basin during the Middle Miocene to Late Miocene (15 to 6.5 Ma): (1) the upper Middle Miocene (15 to 11.63 Ma) characterized by a moderate sediment supply and high aggradation margin induced by rapid subsidence, (2) the lower Upper Miocene (10.8 to 10 Ma) as a high sediment supply and low aggradation margin associated with reworked sediments from the uplifted Dolgorae Thrust and (3) the uppermost Miocene (9.2 to 6.5 Ma) characterized by a low sediment supply and low aggradation margin experiencing sediment starvation. A comparison with worldwide continental margins indicated that the Ulleung Basin formed under a relatively low rate of progradation (low sediment supply; 4.79 km/Myr) and a high rate of aggradation (high shelf accommodation; 361.04 m/Myr) condition. The SW margin of the Ulleung Basin provides a unique example of understanding stratigraphic architecture variations under changing stress regimes of back‐arc setting (extensional to compressional) and understanding of individual controls that influence margin development.
Matching decision support modeling frameworks to disease emergence stages and associated management objectives
Authors: Grant Evan H. Campbell , Mosher Brittany A. , Bernard Riley F. , Wright Alexander D. , Russell Robin E. 
Published: March 2024

AbstractWildlife disease management decisions often require rapid responses to situations that are fraught with uncertainty. By recognizing that management is implemented to achieve specific objectives, resource managers and science partners can identify an analysis technique and develop a monitoring plan to evaluate management effectiveness. For emerging infectious diseases, objectives may take several distinct forms, dependent on the perceived stage of disease emergence (i.e., pre‐epidemic, early outbreak, mid‐epidemic, and endemic), the expected rate of spread, and the anticipated effect of the disease on host populations. Identifying modeling techniques and metrics that are linked to management objectives will require early and consistent communication between managers and science partners. We link modeling approaches that can be used to forecast and evaluate the performance of intervention strategies with a range of disease management objectives. Our aim is to help scientists recognize alternative modeling approaches which may better align with different forms of disease management objectives, and to help managers evaluate the relevance of proposed modeling approaches to their specified objectives for disease management. Recognizing that disease management objectives can take different forms, and thus require different modeling approaches, can help wildlife disease response teams (i.e., natural resource managers, scientists, and stakeholders working collaboratively) better prepare and respond to disease threats.
Epistemic Vice Rehabilitation: Saints and Sinners Zetetic Exemplarism
Authors: Dunne Gerry , Kotsonis Alkis 
Published: March 2024

AbstractThis paper proposes a novel educational approach to epistemic vice rehabilitation. Its authors Gerry Dunne and Alkis Kotsonis note that, like Quassim Cassam, they remain optimistic about the possibility of improvement with regard to epistemic vice. However, unlike Cassam, who places the burden of minimizing or overcoming epistemic vices and their consequences on the individual, Dunne and Kotsonis argue that vice rehabilitation is best tackled via the exemplarist animated community of inquiry zetetic principles and defeasible‐reasons‐regulated deliberative processes. The vice‐reduction method they propose is made up of four distinct yet complementary components: (1) positive exemplarism of epistemic virtue (saints), (2) negative exemplarism of epistemic vice (sinners), (3) direct teaching/instruction, and (4) cognitive apprenticeship. Dunne and Kotsonis argue that this pedagogical intervention appropriately considers learnings deriving from forensic scrutiny of both ideal and non‐ideal interpersonally calibrated zetetic features integral to knowledge acquisition as well as wider societal influences impacting the development of agents' epistemic character. It bridges research on vice epistemology (Cassam's obstructivist theory), social epistemology (corrupted social processes mitigating against vice rehabilitation), virtue epistemology, and moral exemplarism.
A systematic review of altered resting‐state networks in early deafness and implications for cochlear implantation outcomes
Authors: Jafari Zahra , Kolb Bryan E. , Mohajerani Majid H. 
Published: March 2024

AbstractAuditory deprivation following congenital/pre‐lingual deafness (C/PD) can drastically affect brain development and its functional organisation. This systematic review intends to extend current knowledge of the impact of C/PD and deafness duration on brain resting‐state networks (RSNs), review changes in RSNs and spoken language outcomes post‐cochlear implant (CI) and draw conclusions for future research. The systematic literature search followed the PRISMA guideline. Two independent reviewers searched four electronic databases using combined keywords: ‘auditory deprivation’, ‘congenital/prelingual deafness’, ‘resting‐state functional connectivity’ (RSFC), ‘resting‐state fMRI’ and ‘cochlear implant’. Seventeen studies (16 cross‐sectional and one longitudinal) met the inclusion criteria. Using the Crowe Critical Appraisal Tool, the publications' quality was rated between 65.0% and 92.5% (mean: 84.10%), ≥80% in 13 out of 17 studies. A few studies were deficient in sampling and/or ethical considerations. According to the findings, early auditory deprivation results in enhanced RSFC between the auditory network and brain networks involved in non‐verbal communication, and high levels of spontaneous neural activity in the auditory cortex before CI are evidence of occupied auditory cortical areas with other sensory modalities (cross‐modal plasticity) and sub‐optimal CI outcomes. Overall, current evidence supports the idea that moreover intramodal and cross‐modal plasticity, the entire brain adaptation following auditory deprivation contributes to spoken language development and compensatory behaviours.
Radiosynovectomy in haemophilic synovitis and arthropathy of the knee: A scoping review
Authors: Ray Aaron , Rowbotham Emma 
Published: March 2024

AbstractIntroductionRadiosynovectomy is an established treatment for chronic synovitis in patients with haemophilia. Although its role in rheumatological diseases has diminished, it remains an accepted therapy for haemophilic synovitis.AimThe aim of this scoping review was to map and summarise the evidence surrounding radiosynovectomy in haemophilic knees, identify gaps in the literature and inform future research.ResultsForty‐three manuscripts and abstracts were identified for this review. Evidence was limited to observational studies and Yttrium‐90 was the most studied licensed radioisotope. Radiosynovectomy was associated with a reduction in bleeding frequency and pain, improvements in range of motion and a reduction in the use of factor replacement.ConclusionThe literature reviewed lacks studies of sufficient methodological quality to permit systematic review and meta‐analysis. Systematic review using risk of bias assessment for observational studies should be undertaken to better evaluate the efficacy and safety of radiosynovectomy. A causal relationship between RSV and key clinical outcomes remains undetermined.
Addition of substances to reduce the erosive potential of acidic beverages to tooth enamel: A scoping review
Authors: Jácome Erik Vinícius Martins , Bessa Mariana Silva de , Borges Boniek Castillo Dutra , Torres Ana Clara Soares Paiva 
Published: March 2024

AbstractObjectiveThis scoping review aimed (1) to map, analyse, interpret and synthesize data from in situ studies on which substances were added to acidic beverages to reduce the erosive potential on tooth enamel and (2) to establish the level of evidence of the effectiveness of adding substances to acidic beverages to reduce the erosive potential on tooth enamel.DesignThis is a scoping review, according to the methods from the Joanna Briggs Institute and PRISMA‐ScR, with high‐sensitivity searches in the databases PubMed (MEDLINE), Virtual Health Library, Embase (Elsevier), Scopus (Elsevier), Web of Science and ScienceDirect (Elsevier). In situ studies published in English until December 2022 were included. Studies that did not report a control group were excluded. To map and summarize the results, tables and figures were used.ResultsFrom 895 potentially eligible articles, nine were included. Blackcurrant juices (n = 5) with the addition of calcium (n = 3) or xanthan gum (n = 2) formulations were the most tested in terms of reducing the erosive potential of the beverages on tooth enamel. The profilometer was the equipment of choice (n = 8) for evaluating the loss of enamel structure after the experimental tests.ConclusionsCalcium and xanthan gum are among the most tested by in situ studies, offering promising results in reducing the erosive potential of fruit juices and carbonated and energy drinks.
Cultural factors and family influences on adolescent oral health: qualitative research in a socially disadvantaged population
Authors: Purohit Bharathi M. , Singh Abhinav , Barbi Wagisha , Ahmad Shamshad 
Published: March 2024

AbstractAimThis qualitative study sought to assess the influence of cultural factors and family on oral health behaviour of 12‐ to 15‐year‐old adolescents from the socially disadvantaged population.DesignA qualitative design was developed with focus group discussions (FGDs) among 12‐ to 15‐year‐old adolescents. Four focus groups (n = 32 participants) were created from a selected sample to capture oral health beliefs and practices, oral health‐seeking behaviour along with other relevant information. Focus group discussions were audio‐recorded, transcribed verbatim and translated. Data were analysed thematically and structural coding was applied.ResultsThree key themes that emerged from FGDs were importance of oral health; role of family in oral health behaviour; and beliefs influencing access, prevention and treatment of oral diseases. Cultural background, family values and beliefs were imperative in moulding the behaviour of adolescents towards oral health. The use of traditional oral hygiene aides was a norm in this population.ConclusionsFindings of the study provide greater insights into the authoritative role of family and cultural barriers in the uptake of dental services. The study also highlights the potential value of qualitative research and emphasizes the need to integrate oral health‐associated cultural beliefs and attitudes of the adolescents towards a wider evidence base.
Giving children pocket money to help them understand economic principles in personal budget management and reduce gender gaps in financial matters: Does it work?
Authors: Garyn‐Tal Sharon 
Published: March 2024

AbstractMost children who receive pocket money have no idea how to manage it as they have never been taught financial literacy. However, the existing literature does not focus on the level of financial education and guidance children receive or the degree to which parents supervise their children in making decisions about pocket money. This research aims to fill the gap. This study focuses on the financial decisions of children aged 12–16, comparing 105 parent–child dyads in which the child gets pocket money to 101 parent–child dyads in which the child does not get pocket money. The study's results demonstrate that, unlike previous studies, getting pocket money has no impact on children's excessive consumption of fast food and sweets, whereas society's impact on children's consumer decisions increases when they are given pocket money. In contrast, if children believe their parents make good financial decisions and if parents share the household financial decisions with them, children will make better financial decisions themselves. In addition, consistent with previous research, girls – more than boys – see themselves as influenced by their friends in the context of consumer decisions and perceive of themselves as excessive consumers. Implications for parents as well as government policy are discussed.
Upcycling Classics—Sustainable Design Development through Fabric Manipulation Techniques in Fashion Design Education
Authors: Burns Angela 
Published: March 2024

AbstractAs the sustainable fashion movement gains momentum, there is a growing need to introduce such concepts to the next generation of fashion designer. One approach to produce sustainable designs is upcycling, defined as the salvage and reuse of discarded or found items into new products. This study examines a pedagogical approach for engaging 2nd year undergraduate textile and fashion design students in sustainable fashion design practice. Working in groups, students are challenged to upcycle old clothing into a little black dress, using a keyword as direction for concept, design development, and garment construction techniques. To elevate value in post‐consumer textile waste, it is necessary to develop high‐quality contemporary design outcomes. This teaching approach aims to encourage the revaluation of recyclable resources, the exploration of the creative potential of fabric manipulation techniques, experimental design development, and professional production techniques. This is achieved through the implementation of a design brief that establishes original approaches to upcycling, contrary to the arbitrary processes that are typically used.
Eliciting Empathy Embedded in Design Conversations: Empathic Perspective‐Taking of Design Teachers Towards Design Students, Users and Materials
Authors: Efilti Pelin , Gelmez Koray 
Published: March 2024

AbstractThis paper aims to interrogate the design studio conversations between teachers and students in order to explore the indicators regarding empathy. To investigate design conversations occurring between design teachers and design students, participant observation studies were conducted at two universities in Finland and Turkey. As an empathic indicator, we addressed (1) how design teachers take the perspective of other agencies and (2) what deliveries are utilised for empathic perspective‐taking. It was understood that design teachers identify themselves with both human and non‐human agencies as design students, users and materials. Moreover, deliveries leading to the identification of design teachers with these agencies included both discursive and performative means.
Performance of different machine learning algorithms in identifying undiagnosed diabetes based on nonlaboratory parameters and the influence of muscle strength: A cross‐sectional study
Authors: Xu Ying , Qiu Shanhu , Ye Jinli , Chen Dan , Wang Donglei , Zhou Xiaoying , Sun Zilin 
Published: March 2024

AbstractAims/IntroductionMachine learning algorithms based on the artificial neural network (ANN), support vector machine, naive Bayesian or logistic regression model are commonly used to identify diabetes. This study investigated which approach performed the best and whether muscle strength provided any incremental benefit in identifying undiagnosed diabetes in Chinese adults.MethodsThis cross‐sectional study enrolled 4,482 eligible participants from eight provinces in China, who were randomly divided into the training dataset (n = 3,586) and the testing dataset (n = 896). Muscle strength was assessed by handgrip strength and the number of chair stands in the 30‐s chair stand test. An oral glucose tolerance test was used to ascertain undiagnosed diabetes. The areas under the curve (AUCs) were calculated accordingly and compared with each other.ResultsOf the included participants, 233 had newly diagnosed diabetes. All the four machine learning algorithms, which were developed based on nonlaboratory parameters, showed acceptable discriminative ability in identifying undiagnosed diabetes (all AUCs >0.70), with the ANN approach performing the best (AUC 0.806). Adding handgrip strength or the 30‐s chair stand test to this approach did not increase the AUC further (P = 0.39 and 0.26, respectively). Furthermore, compared with the New Chinese Diabetes Risk Score, the ANN approach showed a larger AUC in identifying undiagnosed diabetes (Pcomparison < 0.01), regardless of the addition of handgrip strength or the 30‐s chair stand test.ConclusionsThe ANN approach performed the best in identifying undiagnosed diabetes in Chinese adults; however, the addition of muscle strength might not improve its efficacy.
Infestation of Anthonomus grandis grandis (Coleoptera: Curculionidae) contributes to forming shelter structures in cotton plants
Authors: do Vale Willian S. , Filho Laélcio N. Ribeiro , dos Santos Iuri , Neto Benício de M. Santos , Araújo Lilian R. , Santana Henrique J. C. , da Silva Thainara F. G. , Bastos Cristina S. , da Silva Carlos A. D. , Zanuncio José C. , Leite Suzany A. , Castellani Maria A. 
Published: March 2024

AbstractHerbivorous arthropods can induce their host to form structures where they shelter during unfavourable periods. The boll weevil, Anthonomus grandis grandis Boheman (Coleoptera: Curculionidae), can spend the off‐season inside cotton plant structures, known as dry bolls, protected from pesticides, natural enemies and heat and desiccation on the soil surface, thereby increasing its survival and preserving its reproductive capacity. However, the relationship between the boll weevil and dry boll formation is not fully understood and requires further study. The formation and external and internal characteristics of dry bolls on cotton plants infested with different densities of boll weevils, and the emergence and survival of this insect from these structures, were evaluated. Compared with non‐infested control plants, plants infested with boll weevil formed almost twice as many dry bolls, which were 2.3 times heavier and with a diameter 1.7 times larger than those on non‐infested plants. Boll weevil infestation reduces the number of bolls and commercial mass of fibre + seeds, reducing productivity and increasing cotton harvest contaminants. However, dry bolls on non‐infested plants demonstrate that other factors are involved in their formation.
Diagnosis, isolation and description of a novel amnoonvirus recovered from diseased fancy guppies, Poecilia reticulata
Authors: Soto Esteban , LaFrentz Benjamin R. , Yun Susan , Megarani Dorothea , Henderson Eileen , Piewbang Chutchai , Johnston Amber E. , Techangamsuwan Somporn , Ng Terry Fei Fan , Warg Janet , Surachetpong Win , Subramaniam Kuttichantran 
Published: March 2024

AbstractThe guppy, Poecilia reticulata, is one of the most common cultured ornamental fish species, and a popular pet fish highly desired by hobbyists worldwide due to its availability of many brilliantly coloured fish of many varieties. The susceptibility of guppies to diseases presents a remarkable concern for both breeders and hobbyists. In this study, we report the emergence of disease in fancy guppies caused by a previously uncharacterized virus in the USA. This virus was isolated from moribund guppies in two separate outbreaks in California and Alabama, from December 2021 to June 2023. The infected guppies presented with acute morbidity and mortality shortly after shipping, displaying nonspecific clinical signs and gross changes including lethargy, anorexia, swimming at the water surface, gill pallor, mild to moderate coelomic distension and occasional skin lesions including protruding scales, skin ulcers and hyperaemia. Histological changes in affected fish were mild and nonspecific; however, liver and testes from moribund fish were positive for Tilapia lake virus (TiLV), the single described member in the family Amnoonviridae, using immunohistochemistry and in situ hybridization, although the latter was weak. A virus was successfully recovered following tissue inoculation on epithelioma papulosum cyprini and snakehead fish cell lines. Whole genome sequencing and phylogenetic analyses revealed nucleotide and amino acid homologies from 78.3%–91.2%, and 78.2%–97.7%, respectively, when comparing the guppy virus genomes to TiLV isolates. Based on the criteria outlined herein, we propose the classification of this new virus, fancy tailed guppy virus (FTGV), as a member of the family Amnoonviridae, with the name Tilapinevirus poikilos (from the Greek ‘poikilos’, meaning of many colours; various sorts, akin to ‘poecilia’).