bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis with multiple organ failure
Authors: França Lionel Riou , Launois Robert , Le Lay Katell , Aegerter Philippe , Bouhassira Myriam , Meshaka Patrick , Guidet Bertrand 
Published: April 2008

Objectives:The aim of this study was to estimate the expected cost and clinical benefits associated with the use of drotrecogin alfa (activated) (Xigris; Eli Lilly and Company; Indianapolis, IN) in the French hospital setting.Methods:The recombinant human activated PROtein C Worldwide Evaluation in Severe Sepsis (PROWESS) study results (1,271 patients with multiple organ failure) were adjusted to 9,948 hospital stays from a database of Parisian area intensive-care units (ICUs)—the CubRea (Intensive Care Database User Group) database. The analysis features a decision tree with a probabilistic sensitivity analysis.Results:The cost per life year gained (LYG) of drotrecogin treatment for severe sepsis with multiple organ failure (European indication) was estimated to be $11,812. At the hospital level, the drug is expected to induce an additional cost of $7,545 per treated patient. The incremental cost-effectiveness ratio ranges from $7,873 per LYG for patients receiving three organ supports during ICU stay to $17,704 per LYG for patients receiving less than two organ supports.Conclusions:Drotrecogin alfa (activated) is cost-effective in the treatment of severe sepsis with multiple organ failure when added to best standard care. The cost-effectiveness of the drug increases with baseline disease severity, but it remains cost-effective for all patients when used in compliance with the European approved indication.
Value of magnetic resonance cholangiopancreatography in the diagnosis of biliary abnormalities in postcholecystectomy patients: A probabilistic cost-effectiveness analysis of diagnostic strategies
Authors: Howard Kirsten , Lord Sarah J. , Speer Anthony , Gibson Robert N. , Padbury Robert , Kearney Brendon 
Published: April 2008

Background:Endoscopic retrograde cholangiopancreatography (ERCP) is considered the gold standard for imaging of the biliary tract but is associated with complications. Less invasive imaging techniques, such as magnetic resonance cholangiopancreatography (MRCP), have a much lower complication rate. The accuracy of MRCP is comparable to that of ERCP, and MRCP may be more effective and cost-effective, particularly in cases for which the suspected prevalence of disease is low and further intervention can be avoided. A model was constructed to compare the effectiveness and cost-effectiveness of MRCP and ERCP in patients with a previous history of cholecystectomy, presenting with abdominal pain and/or abnormal liver function tests.Methods:Diagnostic accuracy estimates came from a systematic review of MRCP. A decision analytic model was constructed to represent the diagnostic and treatment pathway of this patient group. The model compared the following two diagnostic strategies: (i) MRCP followed with ERCP if positive, and then management based on ERCP; and (ii) ERCP only. Deterministic and probabilistic analyses were used to assess the likelihood of MRCP being cost-effective. Sensitivity analyses examined the impact of prior probabilities of common bile duct stones (CBDS) and test performance characteristics. The outcomes considered were costs, quality-adjusted life years (QALYs), and cost per additional QALY.Results:The deterministic analysis indicated that MRCP was dominant over ERCP. At prior probabilities of CBDS, less than 60 percent MRCP was the less costly initial diagnostic test; above this threshold, ERCP was less costly. Similarly, at probabilities of CBDS less than 68 percent, MRCP was also the more effective strategy (generated more QALYs). Above this threshold, ERCP became the more effective strategy. Probabilistic sensitivity analyses indicated that, in this patient group for which there is a low to moderate probability of CBDS, there was a 59 percent likelihood that MRCP was cost-saving, an 83 percent chance that MRCP was more effective with a higher quality adjusted survival, and an 83 percent chance that MRCP had a cost-effectiveness ratio more favorable than $50,000 per QALY gained.Conclusions:Costs and cost-effectiveness are dependent upon the prior probability of CBDS. However, probabilistic analysis indicated that, with a high degree of certainty, MRCP was the more effective and cost-effective initial test in postcholecystectomy patients with a low to moderate probability of CBDS.
Cost of an informatics-based diabetes management program
Authors: Blanchfield Bonnie B. , Grant Richard W. , Estey Greg A. , Chueh Henry C. , Gazelle G. Scott , Meigs James B. 
Published: April 2008

Objectives: The relatively high cost of information technology systems may be a barrier to hospitals thinking of adopting this technology. The experiences of early adopters may facilitate decision making for hospitals less able to risk their limited resources. This study identifies the costs to design, develop, implement, and operate an innovative informatics-based registry and disease management system (POPMAN) to manage type 2 diabetes in a primary care setting.Methods: The various cost components of POPMAN were systematically identified and collected.Results: POPMAN cost $450,000 to develop and operate over 3.5 years (1999–2003). Approximately $250,000 of these costs are one-time expenditures or sunk costs. Annual operating costs are expected to range from $90,000 to $110,000 translating to approximately $90 per patient for a 1,200 patient registry.Conclusions: The cost of POPMAN is comparable to the costs of other quality-improving interventions for patients with diabetes. Modifications to POPMAN for adaptation to other chronic diseases or to interface with new electronic medical record systems will require additional investment but should not be as high as initial development costs. POPMAN provides a means of tracking progress against negotiated quality targets, allowing hospitals to negotiate pay for performance incentives with insurers that may exceed the annual operating cost of POPMAN. As a result, the quality of care of patients with diabetes through use of POPMAN could be improved at a minimal net cost to hospitals.
Monitoring the Stable at the Pasteur Institute
Authors: Simon Jonathan 
Published: April 2008

ArgumentDiphtheria serum production in France was dominated by the Pasteur Institute, which equipped a facility at Garches to produce the antitoxin on a large scale. This article treats the background to the founding of this facility, as well as its day-to-day functioning around 1900. The treatment integrates an examination of the practical undertaking of serum production by the Pasteur Institute with an analysis of the popular perception of the Institute and the mixed financing of the whole venture. We particularly emphasize the “industrial” features of this manufacturing process that involved living units of production, showing how bioassays influenced the destiny of the animals producing the serum. Finally, we argue that this monitoring of the horses, seen as serum-producing units, also provided information on the diseases the sera were intended to treat.
The Administrative Stabilization of Vaccines: Regulating the Diphtheria Antitoxin in France and Germany, 1894–1900
Authors: Hess Volker 
Published: April 2008

ArgumentIt is well known that the development of a diphtheria anti-toxin serum evolved in a competitive race between two groups of researchers, one affiliated with Emil Behring in Berlin and Marburg, and another affiliated with Émile Roux in Paris. Proceeding on the basis of different theoretical assumptions and experimental practices, the two groups developed a therapeutic serum almost simultaneously. But the standardized substance they developed took on very different forms in the two countries. In Germany the new serum was marketed in the private sphere and subjected to state regulations, becoming a kind of prototype of industrial medications. In France, however, the same substance was marketed as a gift of science to humanity and distributed through the communal health care system. This article demonstrates how a new medication emerged from the efforts to produce, market, regulate, distribute, and apply it in the two respective countries. It attributes the difference to the negotiations between the respective actors (scientists, industrialists, politicians, officers, and the public) and institutions (firms, academies, private and public institutes, legislative bodies, professional corporations). I develop this argument on three different levels: First, I stress the importance of the institutional foundations of serum production; second, I illustrate the decisive role played by existing “ways of regulating” in the rapid development of new legal statutes; and third, I describe the consequences that flowed from the respective administrative organization of marketing and dissemination. In sum, I explore how an experimental object was transformed into an object of the public health system and stabilized by administrative means.
The Dynamics ofWertbestimmung
Authors: Hüntelmann Axel C. 
Published: April 2008

ArgumentThe procedure ofWertbestimmungplayed a vital role in the implementation of serum therapy and the standardization of mass-produced pharmaceuticals. In fin-de-siècle Germany, a legal framework was put in place to guarantee serum quality and safety and to minimize any associated public health risks. Because the sera were biological remedies, it was difficult to produce them in uniform quality and the procedure ofWertbestimmung, i.e. determining the potency of the serum based on an objective and comparable value, was extremely complex. Various agents such as bacteria cultures, serum hosts, or test animals had to be regulated. In the years after 1895, numerous efforts to stabilize the procedures ofWertbestimmungwere undertaken by serum producers and members of the state-run survey institute responsible for overseeing serum production. Despite efforts to stabilize the framework and to generate a reliable reference system, the framework's environment and agents were in constant flux: new producers entered the market and procedures were expanded to include other biologicals as well. The article describes the dynamics involved in the sustained efforts to maintain a stable framework in the face of constant alterations between 1895 and the 1920s.
Salivary cortisol levels in children of low-income women with high depressive symptomatology
Authors: Fernald Lia C. H. , Burke Heather M. , Gunnar Megan R. 
Published: April 2008

AbstractChildren (N= 324 boys, 315 girls) between the ages of 2.5 and 6 (mean age = 3.63) were identified in a house to house survey in low-income areas (income <20th percentile nationally) of urban Mexico. The Center for Epidemiologic Studies—Depression Scale was administered to mothers of all children. Salivary cortisol samples were taken in children as a measure of hypothalamic–pituitary–adrenocortical (HPA) system activity at time of arrival (baseline, Time 0), 25 min after arrival (Time 1), and 50 min after arrival (Time 2). Between Time 0 and Time 1, children were administered several cognitive tests. Results of hierarchical linear modeling analyses revealed that higher levels of maternal depressive symptoms were associated with lower baseline cortisol levels in their children (p< .05), while controlling for age, gender, and time since awakening. Higher levels of maternal depressive symptoms were associated with less of an increase in salivary cortisol to the arrival of the experimenters and subsequent cognitive testing (p< .05). All results were moderated by gender, with enhanced cortisol response in girls and no response in boys. These results suggest that among very low-income families, high maternal depressive symptoms are associated with hypoactivity of the HPA system in children, particularly boys.
Gene–environment interaction between peer victimization and child aggression
Authors: Brendgen Mara , Boivin Michel , Vitaro Frank , Girard Alain , Dionne Ginette , Pérusse Daniel 
Published: April 2008

AbstractAlthough peer victimization places children at serious risk for aggressive behavior, not all victimized children are aggressive. The diathesis–stress hypothesis of disease proposes that an environmental stressor such as peer victimization should to lead to maladjustment mostly in those individuals with preexisting genetic vulnerabilities. Accordingly, this study examined whether the link between peer victimization and child aggression is moderated by children's genetic risk for such behavior. Using a sample of 506 6-year-old twins, peer victimization was assessed through peer nominations and aggressive behavior was assessed through peer and teacher reports. Children's genetic risk for aggression was estimated as a function of their co-twin's aggression and the pair's zygosity. Genetic modeling showed that peer victimization is an environmentally driven variable that is unrelated to children's genetic disposition. Results also provided support for the notion of a gene–environment interaction between peer victimization and child's genetic risk for aggressive behavior, albeit only in girls. For boys, peer victimization was related to aggression regardless of the child's genetic risk for such behavior. Different socialization experiences in girls' compared to boys' peer groups may explain the different pattern of results for girls and boys.
Early deprivation and home basal cortisol levels: A study of internationally adopted children
Authors: Kertes Darlene A. , Gunnar Megan R. , Madsen Nicole J. , Long Jeffrey D. 
Published: April 2008

AbstractAnimal studies reveal that early deprivation impairs regulation of the hypothalamic–pituitary–adrenocortical (HPA) axis, potentially increasing vulnerability to stressors throughout life. To examine early deprivation effects on basal HPA axis activity in humans, basal cortisol levels were examined in 164 internationally adopted children who had experienced varying degrees of preadoption deprivation. Duration of institutional care, age at adoption, and parent ratings of preadoption neglect indexed a latent factor ofDeprived Care.Adoption measures of height and weight standardized to World Health Organisation norms indexed a latent factor ofGrowth Delaythat was viewed as another reflection of deprivation. Cortisol samples were collected 3.3–11.6 years postadoption (Md= 7.3 years) at home on 3 days approximately 30 min after wakeup and before bedtime. Both early a.m. levels and the decrease in cortisol across the day were examined. A structural equation model revealed that preadoption Deprived Care predicted Growth Delay at adoption and Growth Delay predicted higher morning cortisol levels and a larger diurnal cortisol decrease.
Emotional difficulties in early adolescence following severe early deprivation: Findings from the English and Romanian adoptees study
Authors: Colvert Emma , Rutter Michael , Beckett Celia , Castle Jenny , Groothues Christine , Hawkins Amanda , Kreppner Jana , O'connor Thomas G. , Stevens Suzanne , Sonuga-Barke Edmund J. S. 
Published: April 2008

AbstractThe study assessed conduct and emotional difficulties in a group of Romanian adoptees at age 11, and serves as a follow-up to assessments made when the children were 6 years old. It was found that there was a significant increase in emotional difficulties, but not conduct problems, for the Romanian sample since age 6. It was also found that emotional difficulty was significantly more prevalent at age 11 in the Romanian group than in a within-UK adoptee group. Emotional difficulties in the Romanian adoptee group were found to be significantly and strongly related to previous deprivation-specific problems (disinhibited attachment, cognitive impairment, inattention/overactivity and quasi-autism); however, the presence of such early problems did not account fully for the onset of later emotional problems. Five contrasting hypotheses concerning possible mediators for later onset of emotional difficulties for the Romanian group were examined. No links were found to duration of deprivation or other deprivation-related indices, stresses/difficulties in the postadoption family environment, or educational attainment and self-esteem. There was some evidence that emotion recognition might play a role in the emergence of these problems, but other measures of social competence and theory of mind showed no associations with the onset of emotional problems.
Substance use and related behaviors among suburban late adolescents: The importance of perceived parent containment
Authors: Luthar Suniya S. , Goldstein Adam S. 
Published: April 2008

AbstractThis study builds upon prior findings of elevated substance use among suburban high school students, examining the ramifications of different parenting dimensions on substance use and related behaviors. The sample consisted of 258 11th graders in an affluent suburban community. Parenting predictors considered included those well-studied previously such as monitoring and closeness, as well as two newer dimensions: perceivedcontainment(stringency of anticipated reactions in reaction to negative behaviors) and perceivedcommitment(e.g., helping the child despite other commitments). Outcomes included self-reported substance use, delinquency, and rule breaking, as well as teacher-rated inattentiveness and school grades. Findings showed elevated substance use among these 17-year-olds compared with national norms, especially among girls. Of the parent predictors, significant unique links with multiple outcomes were found for parents' knowledge of their children's activities and perceived parental containment (stringent repercussions) in reaction to the children's substance use. Notably, students reported that their parents were much more tolerant of their substance use than of other problem behaviors such as rudeness to adults and minor acts of delinquency. Results are discussed along with the implications for practice and research.
Female and male antisocial trajectories: From childhood origins to adult outcomes
Authors: Odgers Candice L. , Moffitt Terrie E. , Broadbent Jonathan M. , Dickson Nigel , Hancox Robert J. , Harrington Honalee , Poulton Richie , Sears Malcolm R. , Thomson W. Murray , Caspi Avshalom 
Published: April 2008

AbstractThis article reports on the childhood origins and adult outcomes of female versus male antisocial behavior trajectories in the Dunedin longitudinal study. Four antisocial behavior trajectory groups were identified among females and males using general growth mixture modeling and included life-course persistent (LCP), adolescent-onset, childhood-limited, and low trajectory groups. During childhood, both LCP females and males were characterized by social, familial and neurodevelopmental risk factors, whereas those on the adolescent-onset pathway were not. At age 32, women and men on the LCP pathway were engaging in serious violence and experiencing significant mental health, physical health, and economic problems. Females and males on the adolescent-onset pathway were also experiencing difficulties at age 32, although to a lesser extent. Although more males than females followed the LCP trajectory, findings support similarities across gender with respect to developmental trajectories of antisocial behavior and their associated childhood origins and adult consequences. Implications for theory, research, and practice are discussed.
TRAFFICKING IN LITERARY AUTHORITY: MUDIE'S SELECT LIBRARY AND THE COMMODIFICATION OF THE VICTORIAN NOVEL
Authors: Roberts Lewis 
Published: April 2008

Of all the devices of our complex and complete civilization, I think this huge circulating library system one of the most convenient and agreeable;…to have…volumes of excellent literature for one's exclusive use, seems to me a real privilege, and capital return for one's money.—Frances Ann Kemble,Further Records 1848–1883
THE ETHIC OF THE GIFT IN GEORGE ELIOT'SDANIEL DERONDA
Authors: Murphy Margueritte 
Published: April 2008

In short, this [the exchange of gifts] represents an intermingling. Souls are mixed with things; things with souls. Lives are mingled together, and this is how, among persons and things so intermingled, each emerges from their own sphere and mixes together. This is precisely what contract and exchange are.—Marcel Mauss,The Gift
Multilingual pronunciation by analogy
Authors: SOONKLANG TASANAWAN , DAMPER ROBERT I. , MARCHAND YANNICK 
Published: April 2008

AbstractAutomatic pronunciation of unknown words (i.e., those not in the system dictionary) is a difficult problem in text-to-speech (TTS) synthesis. Currently, many data-driven approaches have been applied to the problem, as a backup strategy for those cases where dictionary matching fails. The difficulty of the problem depends on the complexity of spelling-to-sound mappings according to the particular writing system of the language. Hence, the degree of success achieved varies widely across languages but also across dictionaries, even for the same language with the same method. Further, the sizes of the training and test sets are an important consideration in data-driven approaches. In this paper, we study the variation of letter-to-phoneme transcription accuracy across seven European languages with twelve different lexicons. We also study the relationship between the size of dictionary and the accuracy obtained. The largest dictionaries of each language have been partitioned into ten approximately equal-sized subsets and combined to give ten different-sized test sets. In view of its superior performance in previous work, the transcription method used is pronunciation by analogy (PbA). Best results are obtained for Spanish, generally believed to have a very regular (‘shallow’) orthography, and poorest results for English, a language whose irregular spelling system is legendary. For those languages for which multiple dictionaries were available (i.e., French and English), results were found to vary across dictionaries. For the relationship between dictionary size and transcription accuracy, we find that as dictionary size grows, so performance grows monotonically. However, the performance gain decelerates (tends to saturate) as the dictionary increases in size; the relation can simply be described by a logarithmic regression, one parameter of which (α) can be taken as quantifying the depth of orthography of a language. We find that α for a language is significantly correlated with transcription performance on a small dictionary (approximately 10,000 words) for that language, but less so for asymptotic performance. This may be because our measure of asymptotic performance is unreliable, being extrapolated from the fitted logarithmic regression.
Not Just Another Pretty Picture
Authors: Stebbins Glenn T. 
Published: April 2008

Neurology of Cognitive and Behavioral Disorders. Orrin
Devinsky and Mark D'Esposito. 2004. New York: Oxford University
Press. 451 pp., $99.95 (HB).A problem with many behavioral neurology texts is the tendency to
minimize the connection between behavior and integrated neuroscience
theory. Often the illustrative neurological principles are not grounded in
behavioral neuroscience, but, instead, present unusual conditions in a
type of “Gee whiz” display. The relationship of these
conditions to neuroscience is often lost. In Neurology of Cognitive
and Behavioral Disorders, the relationship of neurologic condition to
neuroscientific principles is clearly explicated. This is perhaps the
greatest strength of this addition to the Oxford University Press
Contemporary Neurology Series.