bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metallkomplexe mit anionischen Liganden von Elementen der 4. Hauptgruppe, III. Homogene und heterogene (Trichlorstannido)metallat(0)‐Komplexe von Chrom, Molybdän und Wolfram
Authors: Kruck Thomas , Breuer Herbert 
Published: June 2007

AbstractDas Trichlorstannid‐Ion, [SnCl3]−, zeigt ein ausgeprägtes Komplexbildungsvermögen gegenüber Übergangsmetallen in niedrigen Oxidationsstufen. Mit den Hexacarbonylen M(CO)6 (MCr, Mo, W) bildet es die Monosubstitutionsprodukte [M(CO)5SnCl3]− (2a–4a). Die trisubstituierten Derivate [M(CO)3(SnCl3)3]3− (2c, 3c) sind leicht aus den Halbsandwich‐Komplexen M(CO)3(C6H6) zugänglich. Die Hexakis(trichlorstannido)metallat(0)‐Komplexe, [M(SnCl3)6]6− (MCr, Mo) (2e, 3e) deren Existenz bereits ein beachtliches Rückbindungsvermögen des [SnCl3]−‐Liganden aufzeigt, bilden sich bei der Umsetzung von M(C6H6)2 mit [SnCl3]− in Tetrahydrofuran bzw. Aceton. Lediglich CO‐Substitution zum [(π‐C5H5)V(CO)2‐(SnCl3)2]2− (5) findet selbst unter UV‐Bedingungen am π‐C5H5V(CO)4 statt. Lösungsmittelfreie Salze sämtlicher (Trichlorstannido)metallat‐Komplexe erhält man mit voluminösen Kationen, z. B. [NR4]+ (RCH3, C2H5).
Benzothiazol‐N‐oxide, II. Über eine neue Synthese substituierter 2‐Benzothiazolone
Authors: Wagner Klaus , Oehlmann Linthard 
Published: June 2007

Abstract2‐Carbamoylbenzothiazol‐N‐oxide gehen in Gegenwart von Phosphoroxychlorid eine neuartige intramolekulare Redoxreaktion unter Bildung von 2‐Benzothiazolonen ein. In zwei untersuchten Fällen unterliegen unterliegen auch 2‐Äthoxycarbonylbenzothiazol‐N‐oxide dieser Umlagerung. Spektroskopische Daten werden diskutiert.
Photoelektronenspektren und Moleküleigenschaften, XXVII. Chlor‐ und Bromäthylene — Beispiele für Änderungen in π‐ und σ‐Systemen
Authors: Wittel Klaus , Bock Hans 
Published: June 2007

AbstractDie Photoelektronen (PE)‐Spektren der mono‐ und disubstituierten Chlor‐ und Bromäthylene zeigen bis zu 9 isolierte Banden. Die Zuordnung anhand qualitativer MO‐Modelle wird durch Spektrenvergleich, Perfluor‐Effekte und Schwingungsfeinstrukturen gesichert. Aus den zugeordneten Spektren lassen sich MO‐Parameter ablesen. Diese erlauben, die π‐Systeme der verschiedenen Substitutionstypen mit induktiven und konjugativen Effekten der Halogene zu beschreiben.
Natürlich vorkommende Terpen‐Derivate, XLII. Neue Sesquiterpene der Gattung Othonna
Authors: Bohlmann Ferdinand , Zdero Christa , Grenz Michael 
Published: June 2007

AbstractDie Untersuchung von Vertretern aus fünf Sektionen der Gattung Othonna zeigt, daß hier relativ stark oxidierte Furanoeremophilane charakteristisch sind. Die Konstitutionen von 20 neuen Vertretern (1, 2, 6, 7, 9, 11, 12, 14, 16, 18, 28, 31, 34 und 37–43) werden durch ihre Spektren sowie durch chemische Reaktionen geklärt. Daneben werden einige Sequiterpene (24, 35, 36) sowie eine Nor‐Verbindung (22) isoliert und ihrer Struktur geklärt. Die engen chemotaxonomischen Beziehungen zu den Nachbargattungen werden diskutiert.
Multi‐way prediction in the presence of uncalibrated interferents
Authors: Rinnan Åsmund , Riu Jordi , Bro Rasmus 
Published: June 2007

AbstractThe second‐order advantage states that predictions are possible for new samples even if they contain new interferents not taken into account in the calibration model. Traditionally generalised rank annihilation has been widely used for second‐order calibration, but alternative models and algorithms such as PARAFAC is known to often be more accurate when many samples are available. While the calibration step of second‐order calibration has received considerable attention in the literature, the procedure of how to predict has not been investigated in detail when PARAFAC is used. In this paper we test the second‐order advantage using different calibration approaches based on PARAFAC with both simulated and real datasets, focussing on prediction quality as a function of the size of the calibration set, the number and degree of overlap of new interferents and the type and magnitude of noise. Guidelines are given on how to implement predictions in PARAFAC‐based second‐order calibration. Copyright © 2007 John Wiley & Sons, Ltd.
Panic disorders and agoraphobia: Side effects of treatment with an implantable cardioverter/defibrillator
Authors: Godemann Frank , Butter Christian , Lampe Felix , Linden Michael , Schlegl Michael , Schultheiss Hans‐Peter , Behrens Steffen 
Published: June 2007

AbstractBackground: Implantable cardioverter/defibrillator (ICD) treatment has reduced the mortality of patients with a high risk of sudden cardiac death. However, ICD discharges may cause anxiety with respect to new discharges and lead to preventive, for example, phobic, behavior. This study evaluated the frequency of panic disorders and agoraphobia in patients with ICD and assessed the risk factors in their development.Hypothesis: Treatment with ICD represents a risk factor in the development of anxiety disorders.Methods: Ninety patients with ICD were examined using a standardized lifetime Diagnostic Interview of Psychiatric Syndromes (DIPS). This interview makes it possible to estimate the incidence of panic disorders and agoraphobia. The impact of the severity of the underlying cardiac disease, the number of ICD discharges, and the subjective appraisal of the shock experience on the development of panic disorders and agoraphobia was assessed.Results: Fifteen patients (16.7%) developed anxiety disorders after ICD implantation. The incidence was 21% in patients with and 6.9% in patients without ICD discharge. In patients with two or more ICD discharges annually, the incidence of panic disorders and agoraphobia was higher than that in patients with a single ICD discharge annually (62 vs. 10%, p < 0.01). The intensity of self‐observation of their body was significantly related to the development of anxiety disorders (p < 0.001).Conclusion: Panic disorders and agoraphobia are frequent side effects of ICD treatment. Risk factors in the development of these disorders are two or more ICD discharges annually and a negative cognitive appraisal of ICD discharges. Therapeutic efforts should aim at reducing the number of ICD discharges and provide early psychological treatment.
Beta1‐adrenergic receptor gene polymorphisms and response to Beta1‐adrenergic receptor blockade in patients with essential hypertension
Authors: Karlsson J. , Lind L. , Hallberg P. , Michaëlsson K. , Kurland L. , Kahan T. , Malmqvist K. , Öhman K. P. , Nyström F. , Melhus H. 
Published: June 2007

AbstractBackground: Studies suggest that the Ser49Gly and Arg389Gly polymorphisms in the β1‐adrenergic receptor might be of functional importance for the cardiovascular system. Both have been associated with altered receptor activity in vitro, and with hypertension and cardiac failure in vivo.Hypothesis: The aim of this study was to test whether these polymorphisms were associated with the change in heart rate or blood pressure in patients with essential hypertension and left ventricular (LV) hypertrophy treated with the β1‐adrenergic receptor blocker atenolol.Methods: Blood pressure and heart rate were measured in 101 hypertensive patients with echocardiographically verified LV hypertrophy, randomized in a double‐blind study to treatment with either the β1 ‐adrenergic receptor blocker atenolol or the angiotensin II type I receptor antagonist irbesartan. Changes in blood pressure and heart rate were evaluated after 12 weeks. Beta1‐adrenergic receptor genotyping was performed using polymerase chain reaction and restriction fragment length polymorphism.Results: We found no significant associations between the changes in the measured variables and either of the two polymorphisms. However, carriers of the 49Gly allele showed a tendency toward a greater reduction in heart rate compared with patients with the Ser/Ser49 genotype (p = 0.06).Conclusions: The Ser49Gly and Arg389Gly β1‐adrenergic receptor polymorphisms do not seem to exert a major effect on the changes in heart rate and blood pressure during 12 weeks of treatment with atenolol in patients with essential hypertension and LV hypertrophy.
Percutaneous mitral commissurotomy using the metallic valvulotome technique in a critically ill adult
Authors: Ward David E. , Tanner Mark A. 
Published: June 2007

AbstractA 25‐year‐old man presented with cardiogenic shock secondary to rheumatic mitral stenosis. Despite aggressive medical treatment he continued to deteriorate. This report describes the successful use of the metallic valvulotome technique for mitral commissurotomy in the context of a critically ill patient.
Bail‐out stenting for left main coronary artery dissection during catheter‐based procedure: Acute and long‐term results
Authors: Lee Seung‐Whan , Hong Myeong‐Ki , Kim Young‐Hak , Park Jae‐Hyeong , Rhee Kyoung‐Suk , Lee Cheol Whan , Han Ki‐Hoon , Song Jong‐Min , Kang Duk‐Hyun , Song Jae‐Kwan , Kim Jae‐Joong , Park Seong‐Wook , Park Seung‐Jung 
Published: June 2007

AbstractBackground: The optimal treatment of patients with left main coronary artery (LMCA) dissection during catheter‐based procedure remains uncertain.Hypothesis: In cases with significant LMCA dissection occurring during catheter‐based procedure, prompt stent implantation may be safe and associated with favorable clinical outcome.Methods: We evaluated the acute and long‐term results of bail‐out stenting for LMCA dissection occurring during a catheter‐based procedure in 10 patients.Results: Initially, there was no significant stenosis of LMCA segments in these patients. Catheter‐induced dissection occurred in eight patients (during diagnostic angiography in three patients and during guiding catheter manipulation in five patients). Two patients suffered dissection in the setting of stent deployment in other vessels. Therefore, bail‐out stenting for LMCA dissection was performed in a total of 10 patients. In four patients, hypotension developed and an intra‐aortic balloon pump was placed during the procedure. Stents were successfully deployed in all patients; there was no in‐hospital mortality. Six‐month angiographic follow‐up was performed in eight patients. No angiographic restenosis (diameter stenosis ≥50%) was observed in any patient at follow‐up study. During a mean follow‐up of 31 ± 25 months after hospital discharge, there was no major adverse cardiac event (death, myocardial infarction, and target lesion revascularization).Conclusions: Bail‐out LMCA stenting is technically feasible and showed good acute and long‐term results in a small series of patients.
Effectiveness of enhanced external counterpulsation in patients with left main disease and angina
Authors: Lawson William E. , Hui John C. K. , Barsness Gregory W. , Kennard Elizabeth D. , Kelsey Sheryl F. 
Published: June 2007

AbstractBackground: Enhanced external counterpulsation (EECP) is a noninvasive device that uses three pairs of sequentially inflated pneumatic cuffs applied to the lower extremities and synchronized with the heart beat to provide diastolic augmentation, increase coronary blood pressure and flow, venous return and cardiac output, and decrease afterload.Hypothesis: This study examines the safety and effectiveness of EECP therapy in patients with significant left main coronary artery disease (LMD).Methods: In all, 2,861 patients enrolled in the International EECP Patient Registry (IEPR) were divided into three groups, those without LMD (n = 2,377), those with LMD and prior CABG (n = 431), and those with unbypassed LMD (n = 53).Results: Patients with LMD, with or without prior CABG, were significantly more likely to have triple‐vessel disease (98.1 and 88.7%, respectively) than patients without LMD (41.9%). Post‐EECP, 74% without LMD, 75% with LMD with prior CABG, and 65% with unbypassed LMD improved their Canadian Cardiovascular Society (CCS) angina by at least one class (p = NS). There were no differences in the mean decrease in weekly angina episodes (7.1 vs. 8.0 vs. 7.6) and in the mean frequency of weekly nitroglycerinuse (6.6 vs. 8.1 vs. 8.9). At 6‐month follow‐up, the CCS class improved further in all three groups, and there was a further reduction in mean weekly angina episodes (4.7 vs. 4.6 vs. 5.3) and nitroglycerinuse (6.5 vs. 6.8 vs. 8.2). Kaplan‐Meier life table analysis 8 months after starting EECP demonstrated a major cardiovascular event rate of 11.2% in patients without LMD, 15.6% in LMD with CABG, and 24.3% in LMD without prior CABG. Late mortality in unbypassed LMD was 13.2% (confidence interval [CI] 3.3‐23.1) versus 4.8% (CI 2.7‐7.1) in LMD with CABG, and 2.8% (CI 2.1‐3.5) without LMD (p = 0.0039 by log‐rank test).Conclusion: Enhanced external counterpulsation is equally effective in relieving angina in patients with or without LMD. However, the significantly increased late mortality in patients with LMD without prior CABG suggests that early revascularization should be considered in these patients.
Depletion of antioxidants is associated with no‐reflow phenomenon in acute myocardial infarction
Authors: Matsumoto Hidenari , Inoue Nobutaka , Takaoka Hideyuki , Hata Katsuya , Shinke Toshiro , Yoshikawa Ryohei , Masai Hiroyuki , Watanabe Satoshi , Ozawa Toru , Yokoyama Mitsuhiro 
Published: June 2007

AbstractBackground: No‐reflow phenomenon is observed in approximately one‐third of patients after percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI), and is associated with poor functional and clinical outcomes. On the other hand, the formation of free radicals in vasculature exerts deleterious effects on coronary microcirculation.Hypothesis: We hypothesized that redox state in coronary circulation may play a crucial role in no‐reflow phenomenon in AMI.Methods: Consecutive 26 patients with first AMI who underwent primary PCI<24 h after onset were enrolled. Before PCI, blood samples were obtained from coronary sinus to measure plasma or serum antioxidative vitamins (vitamin C, vitamin E, and beta‐carotene) and antioxidative enzymes (extracellular glutathione peroxidase [GPX], superoxide dismutase, and catalase). After PCI, the corrected Thrombolysis In Myocardial Infarction (TIMI) frame count (CTFC) was measured in the target vessel. Patients with TIMI ≤2 flow despite an optimal PCI result were designated as no‐reflow group (Group NR, n = 6) and the others as reflow group (Group R,n = 20).Results: Levels of vitamin C, vitamin E, and GPX before PCI were significantly lower in Group NR than in Group R. The CTFC correlated inversely with levels of vitamin C, vitamin E, and GPX (p < 0.05).Conclusions: Depletion of antioxidants is associated with no‐reflow phenomenon in AMI. These findings strongly suggest that the redox state in coronary circulation plays an important role in the pathogenesis of no‐reflow phenomenon.
Serum carboxyl‐terminal propeptide of procollagen type I in exercise‐induced left ventricular hypertrophy
Authors: Escudero Eduardo M. , Tufare Ana L. , Rebolledo Oscar , Pellegrini Laura , Lobrutto Carlos 
Published: June 2007

AbstractBackground: Left ventricular hypertrophy (LVH) induced by exercise is considered to be a physiologic adaptive mechanism without fibrogenic hyperactivity, as occurs in pathologic hypertrophy.Hypothesis: This study investigated serum markers of collagen synthesis and echo parameters of left ventricular diastolic function (LVdf) in 22 male athletes.Methods: Twenty‐two highly competitive male athletes (10 cyclists, 12 soccer players) were studied with full history, clinical examination, Doppler echocardiogram, and serum concentration of the carboxyl‐terminal propeptide of collagen type I (PIP). They were divided into two groups: normal left ventricular mass (N) with left ventricular mass index (LVMI) < 125 g/m2 (14 athletes) and LVH with LVMI > 125 g/m2 (8 athletes).Results: Age, body surface area, blood pressure, heart rate, and systolic function were not different between the groups. Serum concentration of PIP (N: 163±44.1 μg/1,LVH: 172.7 ± 61.2 μg/1—NS) and LVdf (early to atrial peak mitral flow velocity ratio: [E/A]N: 1.77 ± 0.47, LVH: 1.98 ± 0.70—NS, and early to atrial peak mitral annulus velocity ratio: [Ea/Aa] N: 2.63 ± 0.70, LVMI: 2.55 ± 0.90 LV1.61—NS) were similar in both groups.Conclusions: Normal serum concentration of PIP in athletes with LVH in association with normal LVdf indicates the possibility that in this type of physiologic hypertrophy there is mainly an increase of myocyte size without interstitial fibrosis.
Therapeutic strategies, immediate and mid‐term outcomes in non‐ST‐segment elevation acute coronary syndromes with respect to age: A single‐center registry of 488 consecutive patients
Authors: Leoncini Mario , Maioli Mauro , Bellandi Francesco , Galvani Marcello , Ottani Filippo , Toso Anna , Vincenzo Emilio Di , Gallopin Michela , Dabizzi Roberto Piero 
Published: June 2007

AbstractBackground: Elderly patients with non‐ST‐elevation acute coronary syndromes (NSTE‐ACS) may receive benefit from an early invasive strategy. However, aged patients often suffer from comorbidities that may contraindicate an invasive approach and affect prognosis adversely. The impact of comorbidities on an invasive approach to NSTE‐ACS in the elderly has not been fully investigated.Hypothesis: This study sought to examine the outcome of an unselected population of patients with NSTE‐ACS stratified according to age and treatment approach.Methods: The feasibility and efficacy of an invasive strategy for NSTE‐ACS and the 6‐month outcome were assessed in 253 unselected consecutive patients ≥ 70 years (elderly) and compared with those of 235 unselected consecutive patients < 70 years.Results: Angiography was not performed in 69 patients (86% ≥ 70 years) because of contraindications. In the whole population, the 6‐month event rate was significantly higher in elderly compared with younger patients (22 vs. 14%; odds ratio 1.8, 95% confidence interval 1.1‐2.9; p<0.02). This difference was driven by the high event rate observed in the elderly with contraindications to angiography (47 vs. 16% in the elderly treated invasively; p < 0.002). On the other hand, no significant difference was observed in the 6‐month event rate between elderly and younger patients undergoing an invasive approach (16 vs. 13%; p=0.36). Contraindications to angiography—namely, creatinine ≥ 1.5 mg/dl and elevated troponin I at admission—were the only independent predictors of 6‐month outcome.Conclusions: The invasive approach was feasible in 77% of patients ≥ 70 years. Those with contraindications to angiography showed a poor mid‐term prognosis. The early invasive strategy was associated with more favorable outcomes regardless of age.
Effect of quinapril on the attenuated heart rate recovery of type 2 diabetic subjects without known coronary artery disease
Authors: Sipahi Ilke , Tekin Goknur , Yigit Zerrin , Guzelsoy Deniz , Guven Ozen 
Published: June 2007

AbstractBackground: Heart rate (HR) recovery at 1 minis a measure of the vagal reactivation that occurs after cessation of exercise. Despite ample evidence about the association of attenuated HR recovery with increased mortality, pharmacologic modification of this predictor has not been shown. On the other hand, angiotensin‐converting enzyme (ACE) inhibitors are known to have vagomimetic activity.Hypothesis: We hypothesized that ACE inhibition would increase HR recovery in a group of subjects known to have reduced HR recovery, namely diabetics.Methods: Maximal treadmill exercise stress test was performed in 31 type 2 diabetic and 31 nondiabetic male subjects with similar age, body mass index, and hypertensive status. None of the subjects had known heart disease or evidence of myocardial ischemia during the test. The diabetic subjects, after 2 weeks of treatment with quinapril, underwent a second exercise test. A third test was performed 2 to 3 weeks after cessation of quinapril treatment.Results: At baseline, despite similar exercise capacity, the diabetics had a lower HR recovery at 1 min than nondiabetics (25 ± 8 vs. 31 ± 8 beats/min, p<0.01). Quinapril significantly increased HR recovery at 1 min in diabetics (25 ± 8 beats/min at baseline vs. 28 ± 8 beats/min with quinapril vs. 25 ± 7 beats/min off‐therapy, p < 0.01 by analysis of variance).Conclusions: The attenuated HR recovery of type 2 diabetics can be improved by quinapril. Whether the improvement in HR recovery with ACE inhibition can lead to decreased mortality is currently unknown.
B‐type natriuretic peptide measurement in heart failure
Authors: Spevack Daniel M. , Schwartzbard Arthur 
Published: June 2007

AbstractSerum testing for the hormone B‐type natriuretic peptide (BNP) may have clinical utility in congestive heart failure (CHF). This hormone is secreted predominantly by the left ventricular myocardium in patients with CHF. Measurement of serum BNP may improve diagnosis of CHF and may also help guide therapy in patients with CHF. The literature regarding the clinical utility of BNP measurement in CHF is reviewed.
Weight changes and obesity predict impaired resting and endothelium‐dependent myocardial blood flow in postmenopausal women
Authors: Martin Julie W. , Briesmiester Kerri , Bargardi Anita , Muzik Otto , Mosca Lori , Duvernoy Claire S. 
Published: June 2007

AbstractBackground: Obesity has been associated with impaired endothelial function, but the influence of lifetime weight patterns on endothelial function has not been studied.Hypothesis: We hypothesized that coronary vascular reactivity would be diminished in postmenopausal women with a history of obesity and frequent weight swings.Methods: We performed dynamic N‐13 ammonia positron emission tomography in 18 postmenopausal women with cardiac risk factors. Myocardial blood flow (MBF) was measured at rest, after the cold pressor test (CPT), and after adenosine infusion in order to determine baseline and endothelium‐dependent and ‐independent flows, respectively. Myocardial blood flow was corrected for cardiac work by normalizing to the rate‐pressure product. Weight history was obtained by standardized questionnaire.Results: Normalized rest (n‐rest) MBF correlated negatively with current weight (r=‐0.52, p= 0.026) and weight at age 18 (r = −0.47, p = 0.047). Normalized CPT (n‐CPT) MBF correlated inversely with current weight (r = −0.55, p = 0.018), weight at age 18 (r= −0.605, p = 0.008), and highest weight (r = −0.62, p = 0.006). Higher waist circumference predicted lower n‐rest MBF (r= −0.52, p = 0.028) and n‐CPT MBF (r = −0.48, p = 0.04). The same association was found with hip circumference (r = −0.52, p = 0.028; r = −0.49, p = 0.038, respectively), whereas higher body mass index (BMI) predicted lower n‐CPT MBF (r =‐0.53, p = 0.02). Women with at least four significant weight swings had lower MBF during rest, CPT, and n‐CPT (0.88 vs. 1.19 ml/g/min, p = 0.008; 0.76 vs. 1.23 ml/g/min, p< 0.001; 0.74 vs. 1.10 ml/g/ min, p = 0.009, respectively).Conclusions: Increased waist and hip circumference, weight, and frequent weight swings are associated with impaired resting and endothelium‐dependent MBF in postmenopausal women. These data suggest that lifetime weight patterns may influence cardiovascular risk in women.