bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac tamponade due to coronary artery injury after left upper lobectomy
Authors: Kawakami Toru , Iwakura Tomohiro , Chen Ken , Atsumi Jun , Shimoda Kiyomi , Hiramatsu Miyako , Shiraishi Yuji 
Published: March 2024

Abstract
Background
Cardiac tamponade caused by coronary artery injury is an extremely rare postlobectomy complication. Herein, we present a case of cardiac tamponade due to coronary artery injury after a left upper lobectomy for lung cancer and discuss the possible cause of coronary artery injury.

Case presentation
An 82-year-old man with atrial fibrillation, emphysema, chronic heart failure-associated cardiomegaly, and a history of aortic stenting for an abdominal aortic aneurysm underwent a left upper lobectomy without mediastinal nodal dissection for lung cancer. Twenty-eight hours postoperatively, he lost consciousness and went into shock vitals; computed tomography revealed cardiac tamponade. Emergency surgery was performed, which revealed a left circumflex artery laceration. Although the laceration was successfully repaired, he had a gastrointestinal perforation and developed septic shock. He died 35 days after the lung surgery. Intraoperative injury to the heart cannot be ruled out, but the site of the coronary artery injury was located far from the hilum outside the surgical field during the lobectomy. Three-dimensional computed tomography showed that the site of injury was close to the multiple firing junction of the staples that divided the anterior interlobar fissure. Two staples at the multiple firing junction, which protruded perpendicularly to the cut surface, could injure the coronary artery.

Conclusion
Although we cannot rule out the possibility that the intraoperative manipulation procedures contributed to the coronary artery injury, we speculate that the protruding staples might penetrate the pericardium after lung expansion and eventually injured the coronary artery.
Primary outcome reporting in clinical trials for older adults with depression
Authors: Rodrigues Myanca , Oprea Anna , Johnson Keily , Dufort Alexander , Sanger Nitika , Ghiassi Pegah , Sanger Stephanie , Panesar Balpreet , D'Elia Alessia , Parpia Sameer , Samaan Zainab , Thabane Lehana 
Published: March 2024

Background
Findings from randomised controlled trials (RCTs) are synthesised through meta-analyses, which inform evidence-based decision-making. When key details regarding trial outcomes are not fully reported, knowledge synthesis and uptake of findings into clinical practice are impeded.

Aims
Our study assessed reporting of primary outcomes in RCTs for older adults with major depressive disorder (MDD).

Method
Trials published between 2011 and 2021, which assessed any intervention for adults aged ≥65 years with a MDD diagnosis, and that specified a single primary outcome were considered for inclusion in our study. Outcome reporting assessment was conducted independently and in duplicate with a 58-item checklist, used in developing the CONSORT-Outcomes statement, and information in each RCT was scored as ‘fully reported’, ‘partially reported’ or ‘not reported’, as applicable.

Results
Thirty-one of 49 RCTs reported one primary outcome and were included in our study. Most trials (71%) did not fully report over half of the 58 checklist items. Items pertaining to outcome analyses and interpretation were fully reported by 65% or more of trials. Items reported less frequently included: outcome measurement instrument properties (varied from 3 to 30%) and justification of the criteria used to define clinically meaningful change (23%).

Conclusions
There is variability in how geriatric depression RCTs report primary outcomes, with omission of details regarding measurement, selection, justification and definition of clinically meaningful change. Outcome reporting deficiencies may hinder replicability and synthesis efforts that inform clinical guidelines and decision-making. The CONSORT-Outcomes guideline should be used when reporting geriatric depression RCTs.
Health Care Contact Days Among Older Cancer Survivors
Authors: Gupta Arjun , Chant Emma D. , Mohile Supriya , Vogel Rachel I. , Parsons Helen M. , Blaes Anne H. , Booth Christopher M. , Rocque Gabrielle B. , Dusetzina Stacie B. , Ganguli Ishani 
Published: March 2024

PURPOSE Health care contact days—days spent receiving health care outside the home—represent an intuitive, practical, and person-centered measure of time consumed by health care. METHODS We linked 2019 Medicare Current Beneficiary Survey and traditional Medicare claims data for community-dwelling older adults with a history of cancer. We identified contact days (ie, spent in a hospital, emergency department, skilled nursing facility, or inpatient hospice or receiving ambulatory care including an office visit, procedure, treatment, imaging, or test) and described patterns of total and ambulatory contact days. Using weighted Poisson regression models, we identified factors associated with contact days. RESULTS We included 1,168 older adults representing 4.51 million cancer survivors (median age, 76.4 years, 52.8% women). The median (IQR) time from cancer diagnosis was 65 (27-126) months. In 2019, these adults had mean (standard deviation) total contact days of 28.4 (27.6) and ambulatory contact days of 24.2 (23.6). These included days for tests (8.0 [8.8]), imaging (3.6 [4.1]), visits with any clinicians (12.4 [11.5]), and visits with primary care clinicians (4.4 [4.7]), and nononcology specialists (7.1 [9.4]) specifically. Sixty-four percent of days with a nonvisit ambulatory service (eg, a test) were not on the same day as a clinician visit. Factors associated with more total contact days included younger age, lower income, more chronic conditions, poor self-rated health, and tendency to “go to doctor as soon as feel bad.” CONCLUSION Older adult cancer survivors spent nearly 1 month of the year receiving health care outside the home. This care was largely ambulatory, often delivered by nononcologists, and varied by factors beyond clinical characteristics. These results highlight the need to recognize patient burdens and improve survivorship care delivery, including through care coordination.
MeIS: DNA Methylation-Based Immune Response Signatures for Thyroid Nodule Diagnostics
Authors: Chen Huang , Liu Yiying , Wang Feihang , Sun Jin , Gong Chengxiang , Zhu Min , Xu Minjie , He Qiye , Liu Rui , Su Zhixi , Zhong Dingrong , Liu Lingxiao 
Published: March 2024

Abstract

Context
Accurately distinguishing between benign thyroid nodules (BTNs) and papillary thyroid cancers (PTCs) with current conventional methods poses a significant challenge.

Objective
We identify DNA methylation markers of immune response–related genes for distinguishing BTNs and PTCs.

Methods
In this study, we analyzed a public reduced representative bisulfite sequencing dataset and revealed distinct methylation patterns associated with immune signals in PTCs and BTNs. Based on these findings, we developed a diagnostic classifier named the Methylation-based Immune Response Signature (MeIS), which was composed of 15 DNA methylation markers associated with immune response–related genes. We validated MeIS's performance in 2 independent cohorts: Z.S.'s retrospective cohort (50 PTC and 18 BTN surgery-leftover samples) and Z.S.'s preoperative cohort (31 PTC and 30 BTN fine-needle aspiration samples).

Results
The MeIS classifier demonstrated significant clinical promise, achieving areas under the curve of 0.96, 0.98, 0.89, and 0.90 in the training set, validation set, Z.S.'s retrospective cohort, and Z.S.'s preoperative cohort, respectively. For the cytologically indeterminate thyroid nodules, in Z.S.'s retrospective cohort, MeIS exhibited a sensitivity of 91% and a specificity of 82%; in Z.S.'s preoperative cohort, MeIS achieved a sensitivity of 84% and a specificity of 74%. Additionally, combining MeIS and BRAF V600E detection improved the detecting performance of cytologically indeterminate thyroid nodules, yielding sensitivities of 98% and 87%, and specificities of 82% and 74% in Z.S.'s retrospective cohort and Z.S.'s preoperative cohort, respectively.

Conclusion
The 15 markers we identified can be employed to improve the diagnostic of cytologically indeterminate thyroid nodules.
A Randomized Clinical Trial for Meal Bolus Decision Using Learning-based Control in Adults With Type 2 Diabetes
Authors: Liu Wei , Cai Deheng , Zhang Rui , Zhang Xiuying , Cai Xiaoling , Tao Liyuan , Han Xueyao , Luo Yingying , Li Meng , Wu Wenjing , Ma Yumin , Shi Dawei , Ji Linong 
Published: March 2024

Abstract

Context
We propose an artificial-pancreas-like algorithm (AP-A) that could automatically determine the preprandial insulin dose based on intermittently scanned continuous glucose monitoring (isCGM) data trajectories in multiple dose injection (MDI) therapy.

Objective
We aim to determine whether preprandial insulin dose adjustments guided by the AP-A are as effective and safe as physician decisions.

Methods
We performed a randomized, single-blind, clinical trial at a tertiary, referral hospital in Beijing, China. Type 2 diabetes participants were eligible if they were aged 18 years or older, with a glycated hemoglobin A1c of 8.0% or higher. Eligible participants were randomly assigned (1:1) to the AP-A arm supervised by physician and the conventional physician treatment arm. The primary objective was to compare percentage time spent with sensor glucose level in 3.9 to 10.0 mmol/L (TIR) between the 2 study arms. Safety was assessed by the percentage time spent with sensor glucose level below 3.0 mmol/L (TBR).

Results
A total of 140 participants were screened, of whom 119 were randomly assigned to the AP-A arm (n = 59) or physician arm (n = 60). The TIR achieved by the AP-A arm was statistically noninferior compared with the control arm (72.4% [63.3%-82.1%] vs 71.2% [54.9%-81.4%]), with a median difference of 1.33% (95% CI, −6.00 to 10.94, noninferiority margin −7.5%). TBR was also statistically noninferior between the AP-A and control arms (0.0% [0.0%-0.0%] vs 0.0% [0.0%-0.0%]), respectively; median difference (95% CI, 0.00% [0.00%-0.00%], noninferiority margin 2.0%).

Conclusion
The AP-A–supported physician titration of preprandial insulin dosage offers noninferior glycemic control compared with optimal physician care in type 2 diabetes.
“Alive in Every Fibre”: Chopin and Wharton on Pain, Pleasure, and Private Feeling
Authors: Davis Cynthia J. 
Published: March 2024

Abstract
In this essay, novels by Kate Chopin and Edith Wharton serve to elucidate more widely resonant value-laden distinctions between publicly embodied and quietly internalized responses to pain and pleasure. This fictional archive denigrates the demonstrativeness it associates with people marginalized by ascriptive identities of race and class while endorsing the uncommonly vibrant inner lives of particular elite white subjects. Pain and pleasure are valued for arousing hidden depths of feeling that distinguish a singular subject’s affective life from purportedly commonplace and conformist incarnations. Conceptions of selfhood and otherness hinge on distinctions between a subject afforded a purportedly uncommon, deeply vibrant affect molded by an equally uncommon responsiveness to hedonic stimuli and a person or set of persons whose discernable, often simulated or conventional hedonic feelings are represented as typifying a comparatively depreciated racialized, classed, or gendered norm, or some combination of the three. This high-cultural literary investment in a nonnormative, nonreproducible affective interiority strengthened amid debates about privacy rights, an increasing cultural preference for performative self-presentations, and efforts to standardize the US population into types. Drawing on this context along with both affect theory and affective science, the essay demonstrates these novels’ importance to understanding how an unexpressed inner vitality emerged as distinction’s volitionally unattainable vital sign.
Shocking Therapy: Narrating Racism’s Psychobiological Injuries in Ralph Ellison’s Factory Hospital
Authors: Smith Cera 
Published: March 2024

AbstractTaking seriously Ralph Ellison’s interest in the sympathetic nervous system and his involvement in the Black hospital movement, this article demonstrates how the protagonist’s pain in Invisible Man’s factory hospital scene influences the narrator’s writerly “choices” in the novel’s frame narrative. Scholarship on the novel thoroughly attends to the trope of the protagonist’s invisibility but regularly overlooks his corporeal presence. Invisible Man experiences social invisibility, not as a metaphor but as an embodied, somatic state initiated through racializing violence. This essay offers a psychobiologically attentive reading of the factory hospital scene to investigate the potentialities of the Black protagonist’s embodied living. In the scene, racist doctors injure the protagonist’s brain through electroshock torture, disrupting his cognition and sympathetic nervous system. However, the protagonist’s corporeal development of a new consciousness through racist injury has unintended consequences; his resilient brain charts new pathways of thought, undermining his domination through emotional self-awareness. This essay argues that the protagonist’s patient narrative—written following brain injury—functions as a countertechnology to the doctors’ racializing machine.
Cross-Education Effects of Isokinetic Eccentric Plantarflexor Training on Flexibility, Strength, and Muscle–Tendon Mechanics
Authors: KAY ANTHONY D. , BLAZEVICH ANTHONY J. , TYSOE JESSICA C. , BAXTER BRETT A. 
Published: March 2024

ABSTRACT

Introduction
Large increases in joint range of motion (ROM) have been reported after eccentric resistance training; however, limited data exist describing the associated mechanisms or potential cross-education effects in the contralateral limb. Therefore, the effects of a 6-wk isokinetic eccentric plantarflexor training program were examined in 26 participants.

Methods
Before and after the training program, dorsiflexion ROM, plantarflexor strength, and muscle–tendon unit (MTU) morphology and mechanics were measured in control (n = 13) and experimental (n = 13) young adult groups. Training consisted of 5 sets of 12 maximal isokinetic eccentric plantarflexor contractions twice weekly on the right limb.

Results
Significant (P < 0.05) increases in dorsiflexion ROM (4.0–9.5°), stretch tolerance (40.3–95.9%), passive elastic energy storage (47.5–161.3%), and isometric (38.1–40.6%) and eccentric (46.7–67.0%) peak plantarflexor torques were detected in both trained and contralateral limbs in the experimental group. Significant increases in gastrocnemius medialis and soleus thickness (5.4–6.1%), gastrocnemius medialis fascicle length (7.6 ± 8.5%), passive plantarflexor MTU stiffness (30.1 ± 35.5%), and Achilles tendon stiffness (5.3 ± 4.9%) were observed in the trained limb only. Significant correlations were detected between the changes in trained and contralateral limbs for dorsiflexion ROM (r = 0.59) and both isometric (r = 0.79) and eccentric (r = 0.73) peak torques. No significant changes in any metric were detected in the control group.

Conclusions
Large ROM increases in the trained limb were associated with neurological, mechanical, and structural adaptations, with evidence of a cross-education effect in the contralateral limb being primarily driven by neurological adaptation (stretch tolerance). The large improvements in ROM, muscle size, and strength confirm that isokinetic eccentric training is a highly effective training tool, with potential for use in athletic and clinical populations where MTU function is impaired and current therapies are ineffective.
A FAST Method for Nested Estimation
Authors: Liang Guo , Zhang Kun , Luo Jun 
Published: March 2024

Nested estimation involves estimating an expectation of a function of a conditional expectation and has many important applications in operations research and machine learning. Nested simulation is a classic approach to this estimation, and the convergence rate of the mean squared error (MSE) of nested simulation estimators is only of order [Formula: see text], where Γ is the simulation budget. To accelerate the convergence, in this paper, we establish a jackkniFe-bAsed neSted simulaTion (FAST) method for nested estimation, and a unified theoretical analysis for general functions in the nested estimation shows that the MSE of the proposed method converges at the faster rate of [Formula: see text] or even [Formula: see text]. We also provide an efficient algorithm that ensures the estimator’s MSE decays at its optimal rate in practice. In numerical experiments, we apply the proposed estimator in portfolio risk measurement and Bayesian experimental design in operations research and machine learning areas, respectively, and numerical results are consistent with the theory presented. History: Accepted by Bruno Tuffin, Area Editor for Simulation. Funding: This work was supported by the National Natural Science Foundation of China [Grants 72031006, 72101260, and 72394375]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2023.0118 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2023.0118 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Transportation-Enabled Services: Concept, Framework, and Research Opportunities
Authors: Agatz Niels , Cho Soo-Haeng , Sun Hao , Wang Hai 
Published: March 2024

As a result of rapid advancements in urban infrastructure and technology, transportation is transforming a variety of innovative and emerging services. This paper introduces the concept of transportation-enabled services (TRENS), which is a service model that uses transportation systems to enable and enhance the delivery, accessibility, and effectiveness of nontransportation services. We establish a general framework in which the transportation-enabled services involve four key stakeholders: customers, suppliers, TRENS providers, and transportation carriers. Within this general framework, we present five specific service models: a one-sided market, three variants of two-sided markets, and a three-sided market, each characterized by the interactions among suppliers, TRENS providers, and transportation carriers. Taking different models of transportation-enabled services into consideration, we highlight crucial research opportunities to enhance understanding of the planning, operations, evaluation, and regulation of transportation-enabled services. These research opportunities include demand and supply management, transportation system management and operations, coordination among stakeholders, and the evaluation and regulation of transportation-enabled services. We believe that the emergence, widespread adoption, and popularity of transportation-enabled services will significantly enhance and reshape many services and thus contribute to the overall improvement of future mobility in the broader context of smart cities. History: This paper has been accepted for the Service Science Special Issue on Innovation in Transportation-Enabled Urban Services. Funding: The work of Hai Wang was supported by the Lee Kong Chian Fellowship awarded by Singapore Management University. The work of Hao Sun was supported by the National Natural Science Foundation of China [Grants 72301179].
Shaping of a reflective microjet via the addition of a metal mask onto a dielectric scatterer
Authors: Yang Yu-Jing , Zhang De-Long 
Published: March 2024

The method of shaping a reflective microjet (MJ) via the addition of a metal mask onto a dielectric scatterer is proposed. The study focuses on the effects of size, shape of metal mask, and shape of scatterer on the performance of the MJ. The results show that the mask size is a vital factor in tailoring the characteristic parameters of the MJ, especially the focal length (FL). With a properly designed mask size, the FL can increase by 0.51λ, as much as 4 times the FL of a MJ generated without a metal mask. The mask size dependence of MJ parameters is related to the change of number and position of phase singularity in Poynting vector distribution. And the shapes of the mask and scatterer only slightly affect the optimal mask size at which the FL maximizes. In addition, the MJ generated by the presently proposed scattering system can work in the frequency range of 0.1 THz–1.4 THz. The effect of frequency on MJ properties is related to the dispensation and absorption of material. The proposed method can be used to effectively tailor the FL of the reflective MJ to meet the requirements set by various applications.
28.02 W LD side-pumped CW laser operated at 2.8 µm in YSGG/Er:YSGG/YSGG crystal
Authors: Zhang Huili , Sun Dunlu , Luo Jianqiao , Quan Cong , Zhang Peixiong , Qiao Yang , Dong Kunpeng , Chen Yuwei , Wang Zhentao , Li Hongyuan , Cheng Maojie 
Published: March 2024

We demonstrated a 978 nm laser diode (LD) side-pumped YSGG/Er:YSGG/YSGG composite crystal with a size of Ф 3 mm × 65 mm and continuous-wave (CW) mode. By optimizing resonator length and output mirror transmittance, a maximum output power of 28.02 W is generated, corresponding to slope efficiency of 17.55% and optical-optical efficiency of 12.29%, respectively. The thermal focal lengths are obtained by resonator stability condition. The laser wavelength is centered near 2.8 µm. Moreover, the beam quality factors M
x
2/M
y
2 are fitted to be 8.14 and 7.35, respectively. The above results indicate that a high-performance 2.8 µm CW laser can be achieved by LD side-pumped YSGG/Er:YSGG/YSGG composite crystal with excellent heat dissipation ability, which promotes effectively the development and applications of the mid-infrared solid-state lasers.
On-chip integrated few-mode erbium–ytterbium co-doped waveguide amplifiers
Authors: He Xiwen , Ma Deyue , Zhou Chen , Xiao Mingyue , Chen Weibiao , Zhou Zhiping 
Published: March 2024

We propose for the first time, to the best of our knowledge, an on-chip integrated few-mode erbium–ytterbium co-doped waveguide amplifier based on an 800 nm thick Si3N4 platform, which demonstrates high amplification gains and low differential modal gains (DMGs) simultaneously. An eccentric waveguide structure and a co-propagating pumping scheme are adopted to balance the gain of each mode. A hybrid mode/polarization/wavelength-division (de)multiplexer with low insertion loss and crosstalk is used for multiplexing and demultiplexing in two operation wavebands centered at 1550 nm and 980 nm, where the light in these two bands serves as the signal light and pump light of the amplifier, respectively. The results demonstrate that with an input signal power of 0.1 mW, TE0 mode pump power of 300 mW, and TE1 mode pump power of 500 mW, the three signal modes (TE0/TM0/TE1) all exhibit amplification gains exceeding 30 dB, while maintaining a DMG of less than 0.1 dB.