bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meat-analysis revealed the factors affecting the function of ecological floating bed in removing nitrogen and phosphorus from eutrophic water
Authors: Jia Deyi , Wei Shuainan , Wang Shuguang 
Published: March 2024

Abstract

Ecological floating bed (EFB) has been widely used to remove nitrogen and phosphorus from eutrophic water. However, EFB functions largely vary with different studies. Presently it has not been systematically clear what factors affect EFB functions in removing nitrogen and phosphorus from eutrophic water. In this study, we performed a meta-analysis of 169 articles to discuss the effects of EFB characteristics and experimental conditions on EFB function. Results showed that EFB generally decreased nitrogen and phosphorus concentrations in eutrophic water regardless of EFB characteristics and experimental conditions. EFB functions in removing TN, NH4+-N and TP were large when it was constructed by monocots, included 2–3 plant species, had the area of 1.1-3.0 m2, had the coverage of 21%-40%, or had plant density of 21–60 plants/m2. However, NO3−-N removal by EFB was complicated due to the effects of nitrification and denitrification. EFB functions in removing nitrogen and phosphorus from eutrophic water were also affected by experimental conditions, and reached the largest at water temperature of 16–25℃,experimental duration of 31–60 days, long hydraulic retention time (HRT), or aeration. This study indicated that EFB could significantly decrease the concentrations of nitrogen and phosphorus in eutrophic water, and was an effective technology to control water eutrophication.
Experimental and microscopic analysis of N-(n-butyl) thiophos-phoric triamide on microbial amelioration of red clay properties
Authors: Peng Cheng , OuYang Yi , Li Chao , Wang Dongxing 
Published: March 2024

Abstract

This study aims to analyze the impact of varying dosages of N-(n-butyl) thiophosphoric triamide (NBPT) on the physical and mechanical properties of microbial-induced calcite precipitation (MICP) grouting improved red clay. The research includes XRD and SEM experiments to examine the micro-structural characterization of the specimens and understand the mechanism of NBPT's action on MICP improved red clay. A comprehensive evaluation is conducted to assess the properties of red clay after the introduction of NBPT microbial improvement, the results show that The mechanical properties and peak strength of MICP improved red clay samples showed a tendency to increase and then decrease with the increase of NBPT doping, and the stress-strain curve showed a change from softening to hardening and then back to softening; the improvement effect was in the optimal state at the cut-off point when the doping amount of NBPT was 0.1%. The shrinkage deformation, initial water content, and shrinkage coefficient of the MICP improved red clay samples decreased gradually as the doping amount of NBPT increased. In the residual shrinkage deformation stage (δs2), the water content of the specimen needed to reach the ultimate linear shrinkage gradually increased with NBPT doping, causing it to enter the stable shrinkage deformation stage (δs3) earlier. The difference in CaCO3 content between the upper and lower parts of the specimens gradually decreased with the increase of NBPT doping, and finally tends to be stabilized. The urease inhibitor NBPT can affect the crystal morphology and distribution of the product and intervene in the morphological transformation of vaterite to calcite.
Comparative Research of Factors Influencing Education Mismatch and Skill Mismatch in Vocational Education
Authors: Li Bingqiang , Zu Xueru , Chen Min , Wang Shan , Li Jinzhi , Nie Wenjie , Shen Guihua 
Published: March 2024

Abstract

The phenomenon of segmentation of demand and supply of the skilled talent is directly related to mismatch of vocational education, and mismatches of education and skill are important aspects. Based on the four-year data of CFPS from 2014 to 2020, Stata14.0 was adopted to measure the incidence of education mismatch and skill mismatch based on vocational education and the M-logit model was adopted to analyze the differences of influencing factors. The results show that indicators such as the regional difference, the marital status, and the specific age own basically no effect on the impact of education mismatch or skill mismatch, and the gender , the industry type, and the enterprise’s type have obvious effects on the cross-occurrence of education mismatch and skill mismatch, and generally show the variability of individual characteristics and job characteristics. The contribution of this study is to adopt the M-logit model to empirically examine the variability of factors influencing the occurrence of education mismatch and skill mismatch among laborers taking vocational education in China.
Community Led Health Promotion to Counter Stigma and Increase Trust Amongst Priority Populations: Lessons from the 2022-2023 UK MPox Outbreak
Authors: Biesty Colette Pang , Hemingway Charlotte , Woolgar James , Taylor Katrina , Lawton Mark David , Waheed Muhammad Wali , Holford Dawn , Taegtmeyer Miriam 
Published: March 2024

Abstract

Background
Stigma, lack of trust in authorities and poor knowledge can prevent health-seeking behaviour, worsen physical and mental health, and undermine efforts to control transmission during disease outbreaks. These factors are particularly salient with diseases such as MPox, for which 96% of cases in the 2022-2023 UK outbreak were identified among gay, bisexual, queer and men who have sex with men (MSM). This study explored stigma and health-seeking behaviour in Liverpool through the lens of the recent MPox outbreak.
Methods
Primary sources of data were interviews with national and regional key informants involved in the MPox response, and participatory workshops with priority populations. Workshop recruitment targeted Grindr users and sex positive MSM; immigrant, black and ethnic minority MSM; and male sex workers in Liverpool. Data were analysed using a deductive framework approach, building on the Health Stigma and Discrimination Framework.
Results
Eleven key informant interviews and five workshops (involving 15 participants in total) were conducted. There were prevalent reports of anticipated and experienced stigma due to MPox public health messaging alongside high demand and uptake of the MPox vaccine and regular attendance at sexual health clinics. Respondents believed the limited impact of stigma on health-seeking behaviour was due to actions by the LGBTQ+ community, the third sector and local sexual health clinics. Key informants from the LGBTQ+ community and primary healthcare felt their collective action to tackle MPox was undermined by central public health authorities citing under-resourcing; a reliance on goodwill; poor communication; and tokenistic engagement. MPox communication was further challenged by a lack of evidence on disease transmission and risk. This challenge was exacerbated by the impact of the COVID-19 pandemic on the scientific community, public perceptions of infectious disease, and trust in public health authorities.
Conclusions
The LGBTQ+ community and local sexual health clinics took crucial actions to counter stigma and support health seeking behaviour during the 2022-2023 UK MPox outbreak. Lessons from rights based and inclusive community-led approaches during outbreaks should be heeded in the UK, working towards more meaningful and timely collaboration between affected communities, primary healthcare, and regional and national public health authorities.
A Toxic Sterolysin From a 1950s Culture of Gymnodinium Veneficum Ballantine.
Authors: Place Allen R. , Ramos-Franco Josefina , Waters Amanda L. , Hamann Mark T. 
Published: March 2024

Abstract

In 1957 Abbott and Ballentine described a highly toxic activity from a dinoflagellate isolated from the English Channel. in 1949 by Mary Park. From a culture maintained at Plymouth Laboratory since 1950, we have been able to isolate two toxic molecules (Abbotoxin and 59-E-Chloro-Abbotoxin), determine the planar structures by analysis of HRMS and 1D and 2D NMR spectra and found them to be karlotoxin (KmTx) congeners. Both toxins kill larval zebrafish with symptoms identical to that described by Abbot and Ballantine for gobies (Gobius virescens). Using surface plasma resonance the sterol binding specificity of karlotoxins is shown to require desmethyl sterols. Our results with black lipid membranes indicate that karlotoxin forms large-conductance channels in the lipid membrane, which are characterized by large ionic conductance, poor ionic selectivity, and a complex gating behavior that exhibits strong voltage dependence and multiple gating patterns. In addition, we show that KmTx 2 pore formation is a highly targeted mechanism involving sterol-specificity. This is the first report of the functional properties of the membrane pores formed by karlotoxins and are consistent with the intial observations of Abbott and Ballentine from 1957.
A transcription factor of SHI family AaSHI1 activates artemisinin biosynthesis genes in Artemisia annua
Authors: Yang Yinkai , Li Yongpeng , Li Pengyang , Zhou Qin , Sheng Miaomiao , Ma Xiaojing , Shoji Tsubasa , Hao Xiaolong , Kai Guoyin 
Published: March 2024

Abstract

Background
Transcription factors (TFs) of plant-specific SHORT INTERNODES (SHI) family play a significant role in regulating development and metabolism in plants. In Artemisia annua, various TFs from different families have been discovered to regulate the accumulation of artemisinin. However, specific members of the SHI family in A. annua (AaSHIs) have not been identified to regulate the biosynthesis of artemisinin.
Results
We found five AaSHI genes (AaSHI1 to AaSHI5) in the A. annua genome. The expression levels of AaSHI1, AaSHI2, AaSHI3, and AaSHI4 genes were higher in trichomes and young leaves, and decreased when the plants were subjected to dark treatment. The expression pattern of these four AaSHI genes was consistent with the expression pattern of four artemisinin biosynthetic genes and their specific regulatory factors. Dual-luciferase reporter assays, yeast one-hybrid assays, and transient transformation in A. annua provided the evidence that AaSHI1 could directly bind to the promoters of artemisinin biosynthetic genes AaADS and AaCYP71AV1, and positively regulate their expressions. This study has presented candidate genes, with AaSHI1 in particular, that can be considered for the metabolic engineering of artemisinin biosynthesis in A. annua.
Conclusions
Overall, a genome-wide analysis of the AaSHI TF family of A. annua was conducted. Five AaSHIs were identified in A. annua genome. Among the identified AaSHIs, AaSHI1 was found to be localized to the nucleus and activate the expression of artemisinin biosynthetic genes including AaADS and AaCYP71AV1. These results indicated that AaSHI1 had positive roles in modulating artemisinin biosynthesis, providing candidate genes for obtaining high-quality new A. annua germplasms.
Examining the learning objectives related to sustainable development in high school physics curricula vis-à-vis the sustainable development goals and revised Bloom’s taxonomy
Authors: ERDEMIR Mustafa 
Published: March 2024

Abstract
This study determines and classifies the learning objectives related to sustainable development (SD) in the physics curricula of the 9th, 10th, 11th, and 12th grades in line with the sustainable development goals set by the United Nations (UN) and Revised Bloom’s Taxonomy (RBT). The classification of learning objectives in line with RBT revealed that these objectives only focus on the cognitive domain, and no learning objectives considering the affective and psychomotor domains were present in the curriculum. Regarding the levels of cognitive learning, the objectives were mainly related to applying, analyzing, and evaluating. The classification of objectives in line with the SD goals showed that the objectives were mostly concerned with the economic pillar of sustainability, followed by the environmental and social pillars. The study concludes that SD-related learning objectives in the physics curriculum are related to the cognitive domain rather than the affective and psychomotor domains.
A fuzzy structural element-based representation of mine wind speed and pressure
Authors: Jia Jinzhang , Xing Yinghuan 
Published: March 2024

Abstract

Shaft wind flow is mostly turbulent, with random pulsation characteristics, the fluid mass point in time and space for the violent random movement, to accurately describe each instantaneous, each space point on the flow of physical quantities is difficult. Under the influence of turbulent pulsation, the nodal pressure energy will rise and fall randomly, and the random fluctuation of mine ventilation resistance test results is inevitable. In this paper, we design a ventilation channel model without external perturbation, use laser Doppler velocimeter (LDA) and digital micropressure meter to measure the wind flow velocity and relative static pressure in the channel model, obtain the time series of wind speed and pressure, introduce the method of fuzzy number generated by fuzzy structural elements to represent the mine ventilation parameters wind speed and pressure, and compute the mine ventilation resistance based on the proposed method of fuzzy number representation. The experiments show that the wind flow is characterized by turbulent random pulsation, and the time series of wind speed is characterized by random pulsation around a certain average value, obeying the "normal distribution", and the distribution curve of the average wind speed in the roadway cross section is irregularly wavy. The instantaneous flow field of turbulent pulsation is irregular, but has statistical average characteristics. The fuzzy structural element representation can describe the size of the statistical average of wind speed and wind pressure in the roadway, and can also describe the fluctuation change of wind speed and wind pressure, which is more accurate and scientific.
Effect of Targeted Parental Education Intervention to identify Early Childhood Development Disorder – Multisite Interventional Study
Authors: Kanniappan Vadivelan , Muthuperumal Prakash , Venkataraman P , Murugesan Anuradha , Chinnasami Balaji , Muthiah Manikumar , Sethuraman Subramanian , R Abishek J , S ShriSruthi , Nambirajan Murali Krishnan , G Angeline Grace , S Veeragoudhaman T , Deivasigamani Kuberan 
Published: March 2024

Abstract

Background: In India, approximately 3.5 million children face developmental disabilities (DD) due to preterm birth, resulting in neuro-motor immaturity and increased financial burden for families. Maternal unemployment rates are also elevated in such cases. Delayed DD identification, often due to a lack of parental awareness, further compounds these challenges. This study introduces a multiphasic approach to educate antenatal women on monitoring neuro-motor maturity.
Methods: Antenatal women will be assigned to intervention or control groups. The intervention group will undergo specialized training in a multiphasic study, while the control group will receive routine care. A meticulously developed intervention module for early detection of neurodevelopmental disorders will empower mothers to monitor their newborns for potential deficits.
Discussion: This study will assess the effectiveness of training in evaluating developmental disability and neuro-motor maturity. Home interventions by mothers and true/false positive rates of self-referrals will be systematically evaluated. Findings will enable parents to access medical services through the e-Sanjeevini portal promptly for early problem detection.
This study will introduce an innovative, multiphasic approach to address the challenges associated with developmental disabilities in India. By enhancing parental awareness and providing practical tools for early detection, the study aims to reduce the burden on families and improve long-term outcomes for children with DD.
Trial registration: Trail has submitted for registration under Clinical Trails Registry - India (REF/2024/01/078593) and is under review.
Characterizing inducible tertiary lymphoid structures in oral lichen planus: implications for stromal-immune cells interaction and disease severity
Authors: Tang Guoyao , Lai Yirao , Pan Lei , Jiang Xinke , Deng Yiwen , Feng Minghua , Li Jin , Han Xiaozhe , Sun Lei , Wang Yufeng 
Published: March 2024

Abstract

Stromal-immune cells interaction and their contribution in the pathogenesis of oral mucositis, remained not fully understood. This made it hard to clarify the underlying mechanism linking systemic immunity and regional immune microenvironment. The present study aims to elucidate the underpinnings of oral lichen planus (OLP) by focusing on the role of inducible tertiary lymphoid structures (iTLSs) and their impact on disease progression. Employing single-cell RNA sequencing and multiple immunofluorescences, we identified distinct cellular compositions and stromal-immune cells interactions within the iTLSs of OLP. We particularly highlighted the role of CCL19+ fibroblasts and HEV cells. These stromal cells might play a crucial role in facilitating lymphocytes trafficking from peripheral blood to the local inflammation sites within oral mucosa, thereby promoting the formation of iTLSs in OLP. Our findings also revealed a significant correlation between the presence of iTLSs and increased severity of OLP, marked by more atrophic-erosive forms and higher REU scores in patients with iTLSs. The present research offered new insights into the pathogenic mechanisms of OLP, proposing the stromal-immune cell interactions within iTLSs as essential factors in the disease's inflammatory milieu. These findings contributed to uncovering the specific regional pathological features in OLP. Hence, the characterization of iTLSs provided a fundamental foundation for further studies in oral mucosal immunity.
Controlled synthesis of ZnO and Mn-doped ZnO nanoparticles for applications in low-frequency Di-electric Devices
Authors: Sajid Muhammad , Raheem Abdur , Nouman Khan Muhammad , Rahman Atiq , Shujah Sidra , Adil Muhammad 
Published: March 2024

Abstract
Transition metal oxide (TMOs) nanomaterials have gotten remarkable attention due to their vast potential applications in the field of science and technology. In this study, a controlled and facile synthesis route was applied for the preparation of manganese (Mn) doped ZnO nanoparticles (NPs). The percentage of dopant, manganese (Mn) in the host matrix ZnO varied from 2%, 4%, 6%, and 8%. The physical properties of all the prepared samples were examined by x-ray diffractometry (XRD), transmission electron microscope (TEM), UV-vis spectroscopy (UV), and LCR meter. XRD analysis confirms a defect-free hexagonal wurtzite crystal structure (JCPDS No. 036-1451) for all the prepared nanostructures. The overall crystalline size shows an increasing trend from ~17nm to ~ 34nm with Mn doping. The surface morphology was investigated by TEM, which indicated all the prepared NPs are spherical/cubic. The absorption and energy band gap of the synthesized nanoparticle was carried out by using UV-visible spectroscopy which shows that the energy band gap increases from 2.91 eV to 3.33 eV with changing the size of the prepared NPs. The dielectric constant increases with increasing the dopant Mn concentrations which is also been conformed from the ac conductivity.
A Hybrid Structure based on Silk Fibroin/PVA Nanofibers and Alginate/Gum Tragacanth Hydrogel Embedded with Cardamom Extract
Authors: Irantash Shadan , Gholipour-Kanani Adeleh , Najmoddin Najmeh , Varsei Mehdi 
Published: March 2024

Abstract

Hybrid structures made of natural-synthetic polymers have been interested due to high biological features combining promising physical-mechanical properties. In this research, a hybrid dressing consisting of a silk fibroin (SF)/polyvinyl alcohol (PVA) nanofibers and sodium alginate (SA)/gum tragacanth (GT) hydrogel incorporating cardamom extract as an antibacterial agent was prepared. Accordingly, SF was extracted from cocoons followed by electrospinning in blend form with PVA (SF/PVA ratio: 1:1) under the voltage of 18 kV and the distances of 15 cm. The SEM images confirmed the formation of uniform, bead free fibers with the average diameter of 199±28 nm. FTIR and XRD results revealed the successful extraction of SF and preparation of mixed fibrous mats. Next, cardamom oil extract-loaded SA/GT hydrogel was prepared and the nanofibrous structure was placed on the surface of hydrogel. SEM analysis depicted the uniform morphology of hybrid structure with desirable matching between two layers. TGA analysis showed desired thermal stability. The swelling ratio was found to be 1251% after 24 h for the hybrid structure and the drug was released without any initial burst. MTT assay and cell attachment results showed favorable biocompatibility and cell proliferation on samples containing extract, and antibacterial activity values of 85.35% against S. aureus and 75% against E. coli were obtained as well. The results showed that the engineered hybrid nanofibrous-hydrogel film structure incorporating cardamom oil extract could be a promising candidate for wound healing applications and skin tissue engineering.
HippoMaps: Multiscale Cartography of Human Hippocampal Organization
Authors: DeKraker Jordan , Cabalo Donna , Royer Jessica , Khan Ali , Karat Bradley , Benkarim Oualid , Cruces Raul R. , Frauscher Birgit , Pana Raluca , Hansen Justine , Misic Bratislav , Valk Sofie , Lau Jonathan , Kirschner Matthias , Bernsconi Andrea , Bernasconi Neda , Muenzing Sascha , Axer Markus , Amunts Katrin , Evans Alan , Bernhardt Boris 
Published: March 2024

Abstract
The hippocampus has a unique microarchitecture, is situated at the nexus of multiple macroscale functional networks, contributes to numerous cognitive as well as affective processes, and is highly susceptible to brain pathology across common disorders. These features make the hippocampus a model to understand how brain structure covaries with function, in both health and disease. Here, we introduce HippoMaps, an open access toolbox and online data warehouse for the mapping and contextualization of hippocampal data in the human brain (http://hippomaps.readthedocs.io). HippoMaps capitalizes on a novel hippocampal unfolding approach as well as shape intrinsic registration capabilities to allow for cross-subject and cross-modal data aggregation. We initialize this repository with data spanning 3D post-mortem histology, ex-vivo9.4 Tesla MRI, as well as in-vivo structural MRI and resting-state functional MRI (rsfMRI) obtained at 3 and 7 Tesla, together with intracranial encephalography (iEEG) recordings in epilepsy patients. HippoMaps also contains validated tools for spatial map association analysis in the hippocampus that correct for autocorrelation. All code and data are compliant with community standards, and comprehensive online tutorials facilitate broad adoption. Applications of this work span methodologies and modalities, spatial scales, as well as clinical and basic research contexts, and we encourage community feedback and contributions in the spirit of open and iterative scientific resource development.