bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potent antitumor activity of the anti-CD19 auristatin antibody drug conjugate hBU12-vcMMAE against rituximab-sensitive and -resistant lymphomas
Authors: Gerber Hans-Peter , Kung-Sutherland May , Stone Ivan , Morris-Tilden Carol , Miyamoto Jamie , McCormick Renee , Alley Stephen C. , Okeley Nicole , Hayes Brad , Hernandez-Ilizaliturri Francisco J. , McDonagh Charlotte F. , Carter Paul J. , Benjamin Dennis , Grewal Iqbal S. 
Published: January 2009

AbstractDespite major advances in the treatment of non-Hodgkin lymphoma (NHL), including the use of chemotherapeutic agents and the anti-CD20 antibody rituximab, the majority of patients eventually relapse, and salvage treatments with non–cross-resistant compounds are needed to further improve patient survival. Here, we evaluated the antitumor effects of the microtubule destabilizing agent monomethyl auristatin E (MMAE) conjugated to the humanized anti-CD19 antibody hBU12 via a protease-sensitive valine-citrulline (vc) dipeptide linker. hBU12-vcMMAE induced potent tumor cell killing against rituximab-sensitive and -resistant NHL cell lines. CD19 can form heterodimers with CD21, and high levels of CD21 were reported to interfere negatively with the activity of CD19-targeted therapeutics. However, we observed comparable internalization, intracellular trafficking, and drug release in CD21low and CD21high, rituximab-sensitive and -refractory lymphomas treated with hBU12-vcMMAE. Furthermore, high rates of durable regressions in mice implanted with these tumors were observed, suggesting that both rituximab resistance and CD21 expression levels do not impact on the activity of hBU12-vcMMAE. Combined, our data suggest that hBU12-vcMMAE may represent a promising addition to the treatment options for rituximab refractory NHL and other hematologic malignancies, including acute lymphoblastic leukemia.
Erratum to: Chromosomal evolution of the PKD1gene family in primates
Authors: Kirsch Stefan , Pasantes Juanjo , Wolf Andreas , Bogdanova Nadia , Münch Claudia , Markoff Arseni , Pennekamp Petra , Krawczak Michael , Dworniczak Bernd , Schempp Werner 
Published: January 2009

Abstract
Correction to Kirsch S, Pasantes J, Wolf A, Bogdanova N, Münch C, Pennekamp P, Krawczak M, Dworniczak B, Schempp W: Chromosomal evolution of the

PKD1

gene family in primates. BMC Evolutionary Biology 2008, 8:263 (doi:10.1186/1471-2148-8-263)
Origins of submovements in movements of elderly adults
Authors: Fradet Laetitia , Lee Gyusung , Dounskaia Natalia 
Published: January 2009

Abstract

Background
Slowness is a well-recognized feature of movements in aging. One of the possible reasons for slowness suggested by previous research is production of corrective submovements that compensate for shortened primary submovement to the target. Here, we re-examine this traditional interpretation and argue that the majority of submovements in older adults may be a consequence rather than the cause of slowness.

Methods
Pointing movements in young and older adults were recorded. Conditions for submovement emergence were manipulated by using small and large targets and three movement modes: discrete (required stopping on the target), reciprocal (required reversal on the target), and passing (required crossing the target and stopping after that). Movements were parsed into a primary and secondary submovement based on zero-crossings of velocity (type 1 submovements), acceleration (type 2 submovements), and jerk (type 3 submovements). In the passing mode, secondary submovements were analyzed only after crossing the target to exclude that they were accuracy adjustments.

Results
Consistent with previous research, the primary submovement was shortened and total secondary submovement incidence was increased in older adults. However, comparisons across conditions suggested that many submovements were non-corrective in both groups. Type 1 submovements were non-corrective because they were more frequent for large than small targets. They predominantly emerged due to arm stabilization and energy dissipation during motion termination in the discrete and passing mode. Although type 2 and 3 submovements were more frequent for small than large targets, this trend was also observed in the passing mode, suggesting that many of these submovements were non-corrective. Rather, they could have been velocity fluctuations associated predominantly with low speed of movements to small targets.

Conclusion
The results question the traditional interpretation of frequent submovements in older adults as corrective adjustments. Rather, the increased incidence of submovements in older adults is directly related to low movement speed observed in aging, whereas the relationship between submovement incidence and target size is a result of speed-accuracy trade-off. Aging-related declines in muscular control that may contribute to the disproportional increases in submovement incidence during slow movements of older adults are discussed.
The Neuroscience Peer Review Consortium
Authors: Saper Clifford B , Maunsell John HR , Sagvolden Terje 
Published: January 2009

Abstract
The Neuroscience Peer Review Consortium (NPRC) was conceived in the summer of 2007 at a meeting of editors and publishers of neuroscience journals. One of the working groups addressed whether it was possible to construct a system for permitting authors whose manuscript received supportive reviews at one journal but was not accepted to send a revised manuscript together with its first round of reviews to a new journal for the second round. This would speed up the review process and reduce the work for reviewers and editors. The working group not only designed a framework for transferring reviews among journals, but also implemented it as the NPRC. By the fall of 2007, more than a dozen major journals had signed onto the NPRC, sufficient to launch the experiment in January, 2008. We invite authors who have not yet used the NPRC to try this method for appropriate manuscripts.
In order to encourage dissemination of the details outlined in this Editorial, it will also be published in other journals in the Neuroscience Peer Review Consortium.
The impact of iron supplementation efficiency in female blood donors with a decreased ferritin level and no anaemia. Rationale and design of a randomised controlled trial: a study protocol
Authors: Pedrazzini Baptiste , Waldvogel Sophie , Cornuz Jacques , Vaucher Paul , Bize Raphael , Tissot Jean-Daniel , Pecoud Alain , Favrat Bernard 
Published: January 2009

Abstract

Background
There is no recommendation to screen ferritin level in blood donors, even though several studies have noted the high prevalence of iron deficiency after blood donation, particularly among menstruating females. Furthermore, some clinical trials have shown that non-anaemic women with unexplained fatigue may benefit from iron supplementation. Our objective is to determine the clinical effect of iron supplementation on fatigue in female blood donors without anaemia, but with a mean serum ferritin ≤ 30 ng/ml.

Methods/Design
In a double blind randomised controlled trial, we will measure blood count and ferritin level of women under age 50 yr, who donate blood to the University Hospital of Lausanne Blood Transfusion Department, at the time of the donation and after 1 week. One hundred and forty donors with a ferritin level ≤ 30 ng/ml and haemoglobin level ≥ 120 g/l (non-anaemic) a week after the donation will be included in the study and randomised. A one-month course of oral ferrous sulphate (80 mg/day of elemental iron) will be introduced vs. placebo. Self-reported fatigue will be measured using a visual analogue scale. Secondary outcomes are: score of fatigue (Fatigue Severity Scale), maximal aerobic power (Chester Step Test), quality of life (SF-12), and mood disorders (Prime-MD). Haemoglobin and ferritin concentration will be monitored before and after the intervention.

Discussion
Iron deficiency is a potential problem for all blood donors, especially menstruating women. To our knowledge, no other intervention study has yet evaluated the impact of iron supplementation on subjective symptoms after a blood donation.

Trial registration
NCT00689793
Inhibitors of V-ATPases: old and new players
Authors: Huss Markus , Wieczorek Helmut 
Published: January 2009

SUMMARYV-ATPases constitute a ubiquitous family of heteromultimeric, proton translocating proteins. According to their localization in a multitude of eukaryotic endomembranes and plasma membranes, they energize many different transport processes. Currently, a handful of specific inhibitors of the V-ATPase are known, which represent valuable tools for the characterization of transport processes on the level of tissues, single cells or even purified proteins. The understanding of how these inhibitors function may provide a basis to develop new drugs for the benefit of patients suffering from diseases such as osteoporosis or cancer. For this purpose, it appears absolutely essential to determine the exact inhibitor binding site in a target protein on the one side and to uncover the crucial structural elements of an inhibitor on the other side. However, even for some of the most popular and long known V-ATPase inhibitors, such as bafilomycin or concanamycin, the authentic structures of their binding sites are elusive. The aim of this review is to summarize the recent advances for the old players in the inhibition game, the plecomacrolides bafilomycin and concanamycin, and to introduce some of the new players, the macrolacton archazolid, the benzolactone enamides salicylihalamide, lobatamide, apicularen, oximidine and cruentaren, and the indolyls.
Insect homeostasis: past and future
Authors: Maddrell Simon 
Published: January 2009

SUMMARYMost of my work has been on the hormonal control of fluid secretion by insect Malpighian tubules. My present purpose is mostly to describe some previously unpublished results in this area and put them in context of what was already known. In this, I hope to draw attention to some areas where future research might be productive.
Rapid Flow Cytometry–Based Structural Maintenance of Chromosomes 1 (SMC1) Phosphorylation Assay for Identification of Ataxia-Telangiectasia Homozygotes and Heterozygotes
Authors: Nahas Shareef A , Butch Anthony W , Du Liutao , Gatti Richard A 
Published: January 2009

AbstractBackground: No rapid reliable method exists for identifying ataxia-telangiectasia (A-T) homozygotes or heterozygotes. Heterozygotes are at an increased risk of cancer and are more sensitive to the effects of ionizing radiation (IR) than the general population. We report a rapid flow cytometry (FC)-based ataxia-telangiectasia mutated (ATM) kinase assay that measures ATM- dependent phosphorylation of structural maintenance of chromosomes 1 (SMC1) following DNA damage (FC-pSMC1 assay).Methods: After optimizing conditions with lymphoblastoid cell lines (LCLs), we studied peripheral blood mononuclear cells (PBMCs) isolated from 16 healthy donors (unknowns), 10 obligate A-T heterozygotes, and 6 unrelated A-T patients. One hour after DNA damage (by either IR or bleomycin), the cells were fixed and incubated with a primary antibody to SMC1pSer966. We analyzed the stained cells by FC to determine the difference in geometric mean fluorescence intensity (ΔGMFI) of untreated and treated cells; this difference was expressed as a percentage of daily experimental controls.Results: The FC-pSMC1 assay reliably distinguished ATM heterozygotes and homozygotes from controls. Average ΔGMFI percentages (SD) of daily controls were, for unknowns, 106.1 (37.6); for A-T heterozygotes, 37.0 (18.7); and for A-T homozygotes; −8.73 (16.2). Values for heterozygotes and homozygotes were significantly different from those of controls (P &lt; 0.0001).Conclusions: The FC-pSMC1 assay shortens the turnaround time for diagnosing A-T homozygotes from approximately 3 months to approximately 3 h. It also identifies A-T heterozygotes and can be used for prenatal counseling or for screening individuals in large study cohorts for potential ATM heterozygosity, which can then be confirmed by sequencing.
Minimizing Cardiotoxicity While Optimizing Treatment Efficacy with Trastuzumab: Review and Expert Recommendations
Authors: Martín Miguel , Esteva Francisco J. , Alba Emilio , Khandheria Bijoy , Pérez-Isla Leopoldo , García-Sáenz José Ángel , Márquez Antonia , Sengupta Partho , Zamorano José 
Published: January 2009

Learning Objectives
Analyze the clinical trial data for the treatment of breast cancer. Evaluate the risk of cardiotoxicity associated with the use of trastuzumab. Design and conduct a practical approach to managing patients with trastuzumab-associated cardiotoxicity.
This article is available for continuing medical education credit at CME.TheOncologist.com.
Commentary: Disclosure in Oncology—To Whom Does the Truth Belong?
Authors: Wood William A. , McCabe Mary S. , Goldberg Richard M. 
Published: January 2009

Learning ObjectivesSummarize the meaning of the term “therapeutic nondisclosure” in the context of medical oncology practice. Classify the reasons for variations in disclosure practices around the world. Develop strategies for approaching a conversation about disclosure that respects the rights and needs of the patient and family.This article is available for continuing medical education credit at CME.TheOncologist.com.
State-Level Moderation of Genetic Tendencies to Smoke
Authors: Boardman Jason D. 
Published: January 2009

Objectives. I examined genetic influences on smoking among adolescents and differences in the heritability of smoking across states in the United States. Methods. With data from the National Longitudinal Study of Adolescent Health (participants aged 12–21 years), I used a multilevel twin- and sibling-pair (N = 2060 pairs) regression model. Results. Daily smoking (hereditability estimate [h2] = 0.54) and smoking onset (h2 = 0.42) were both highly heritable. Whereas the genetic influences on smoking onset were consistent across states, there was significant variation in these influences on daily smoking. Genetic influences on daily smoking were lower in states with relatively high taxes on cigarettes and in those with greater controls on the vending machines and cigarette advertising. Genetic influences were also negatively associated with rates of smoking among youths. Conclusions. At the state level, gene–environment interaction models are best characterized by the model of social control. State policies may influence genetic tendencies to smoke regularly, but they have not affected the genetic contributions to cigarette onset or experimentation. Future tobacco-control policies may emphasize the heritable endophenotypes that increase the likelihood that adolescents will initiate smoking.
Competing Initiatives: A New Tobacco Industry Strategy to Oppose Statewide Clean Indoor Air Ballot Measures
Authors: Tung Gregory J. , Hendlin Yogi H. , Glantz Stanton A. 
Published: January 2009

To describe how the tobacco and gaming industries opposed clean indoor air voter initiatives in 2006, we analyzed media records and government and other publicly available documents and conducted interviews with knowledgeable individuals. In an attempt to avoid strict “smoke free” regulations pursued by health groups via voter initiatives in Arizona, Ohio, and Nevada, in 2006, the tobacco and gaming industries sponsored competing voter initiatives for alternative laws. Health groups succeeded in defeating the pro-tobacco competing initiatives because they were able to dispel confusion and create a head-to-head competition by associating each campaign with its respective backer and instructing voters to vote “no” on the pro-tobacco initiative in addition to voting “yes” on the health group initiative.
Health Disadvantage in US Adults Aged 50 to 74 Years: A Comparison of the Health of Rich and Poor Americans With That of Europeans
Authors: Avendano Mauricio , Glymour M. Maria , Banks James , Mackenbach Johan P. 
Published: January 2009

Objectives. We compared the health of older US, English, and other European adults, stratified by wealth.Methods. Representative samples of adults aged 50 to 74 years were interviewed in 2004 in 10 European countries (n = 17 481), England (n = 6527), and the United States (n = 9940). We calculated prevalence rates of 6 chronic diseases and functional limitations.Results. American adults reported worse health than did English or European adults. Eighteen percent of Americans reported heart disease, compared with 12% of English and 11% of Europeans. At all wealth levels, Americans were less healthy than were Europeans, but differences were more marked among the poor. Health disparities by wealth were significantly smaller in Europe than in the United States and England. Odds ratios of heart disease in a comparison of the top and bottom wealth tertiles were 1.94 (95% confidence interval [CI] = 1.69, 2.24) in the United States, 2.13 (95% CI = 1.73, 2.62) in England, and 1.38 (95% CI = 1.23, 1.56) in Europe. Smoking, obesity, physical activity levels, and alcohol consumption explained a fraction of health variations.Conclusions. American adults are less healthy than Europeans at all wealth levels. The poorest Americans experience the greatest disadvantage relative to Europeans.
L'underground politique, artistique, rock (1970-1980)
Authors: Klaniczay Gábor 
Published: January 2009

Résumé L’article tente d’analyser les liens d’imbrication entre la politique, les arts, la musique rock, l’opposition, la « contre-culture » et la « subculture » dans les milieux underground budapestois dans les dernières décennies du système socialiste. Après une discussion des traits communs et des différences significatives des concepts de « subculture », « culture populaire », « contre-culture » et « underground », l’article offre une description du contexte politique et artistique de ces phénomènes en Hongrie. L’émergence de la « nouvelle vague » du rock, concomitante de la création des espaces publics alternatifs par les dissidents politiques, offre un cas intéressant pour l’analyse historique et ethnologique.
Microbiologically Influenced Corrosion
Authors: Little Brenda J. , Lee Jason S. 
Published: January 2009

AbstractThe term microbiologically influenced corrosion (MIC) is used to designate corrosion due to the presence and activities of microorganisms, ie, those organisms that cannot be seen individually with the unaided human eye, including microalgae, archaea, bacteria, and fungi. Microorganisms can accelerate rates of partial reactions in corrosion processes or shift the mechanism for corrosion. Microorganisms can influence pitting, dealloying, enhanced erosion corrosion, enhanced galvanic corrosion, stress corrosion cracking, and hydrogen embrittlement. Microbiologically influenced corrosion has been reported for all engineering metals and alloys with the exception of predominantly titanium and high chromium–nickel alloys. It has been documented for metals and nonmetals exposed to seawater, freshwater, distilled/demineralized water, crude and distillate hydrocarbon fuels, process chemicals, foodstuffs, soils, human plasma, saliva, and sewage. The following sections describe the estimated costs of MIC, mechanisms, and causative microorganisms contributing to MIC; techniques for diagnosing, measuring, and monitoring; engineering practices that influence MIC and strategies to prevent or mitigate MIC.
Reversible Addition–Fragmentation Chain Transfer Polymerization
Authors: Rizzardo Ezio , Moad Graeme , Thang San H. 
Published: January 2009

Abstract
This article reviews the mechanistic and practical aspects of free radical polymerization with reversible addition–fragmentation chain transfer—the reversible addition–fragmentation chain transfer (RAFT) process. RAFT is conducted by the addition of a thiocarbonylthio compound (ZC(S)SR) to a conventional radical polymerization. Suitable RAFT agents include dithioesters, trithiocarbonates, dithiocarbamates, and xanthates. These thiocarbonylthio compounds confer living characteristics to the radical polymerization by a mechanism of reversible addition–fragmentation chain transfer and provide exceptional control over molecular weight, molecular weight distribution, composition, and architecture of the resulting polymers. The process can be applied to most monomers polymerizable by radical polymerization and offers a convenient route to well‐defined homo‐, gradient, diblock, triblock, and star polymers as well as more complex architectures including microgels and polymer brushes.
Effect of metal‐support interface on hydrogen permeation through palladium membranes
Authors: Zhang Ke , Wei Xiaotong , Rui Zebao , Li Yongdan , Lin Y. S. 
Published: January 2009

AbstractThin palladium membranes of different thicknesses were prepared on sol‐gel derived mesoporous γ‐alumina/α‐alumina and yttria‐stabilized zirconia/α‐alumina supports by a method combining sputter deposition and electroless plating. The effect of metal‐support interface on hydrogen transport permeation properties was investigated by comparing hydrogen permeation data for these membranes measured under different conditions. Hydrogen permeation fluxes for the Pd/γ‐Al2O3/α‐Al2O3 membranes are significantly smaller than those for the Pd/YSZ/α‐Al2O3 membranes under similar conditions. As the palladium membrane thickness increases, the difference in permeation fluxes between these two groups of membranes decreases and the pressure exponent for permeation flux approaches 0.5 from 1. Analysis of the permeation data with a permeation model shows that both groups of membranes have similar hydrogen permeability for bulk diffusion, but the Pd/γ‐Al2O3/α‐Al2O3 membranes exhibit a much lower surface reaction rate constant with higher activation energy, due possibly to the formation of Pd‐Al alloy, than the Pd/YSZ/α‐Al2O3 membranes. © 2009 American Institute of Chemical Engineers AIChE J, 2009
Factors associated with cancer distress in the Asbestos Post‐Exposure Survey (APEXS)
Authors: Maurel Marion , Stoufflet Audrey , Thorel Laetitia , Berna Veronique , Gislard Antoine , Letourneux Marc , Pairon Jean‐Claude , Paris Christophe 
Published: January 2009

AbstractObjectivesCT‐scan screening programs for lung cancer detection have been proposed in high‐risk subjects, and more recently in former asbestos‐exposed subjects. However, to date no data are available on psychological impact of such programs. The aim of this study is to examine the risk factors of psychological distress at baseline of a CT‐scan screening program among asbestos‐exposed subjects.MethodsThe Asbestos Post‐Exposure Survey (APEXS) was carried out in France between October 2003 and December 2005 in order to screen asbestos‐related diseases by CT‐scan. Volunteers underwent self‐administered questionnaires including an asbestos exposure assessment and, for a large sub‐sample, a validated psychological distress scale. Non‐exposed subjects were used as reference group.ResultsAt baseline, a significant higher level of distress was observed in exposed subjects (n = 3,122) relative to the reference group (n = 486) after adjustment on age, sex, and tobacco status. This distress is associated independently with the self‐perception of (i) intensity of asbestos exposure and (ii) the risk of current or future disease related to the asbestos exposure. The perception of the cancer risk related to asbestos seems to play a fundamental role in this psychological distress.ConclusionIn this study, asbestos‐exposed subjects experienced a higher significant cancer distress than previously described in literature. These findings may be of potential public health importance. First, the impact of such occupational exposures on quality of life of patients who suffer from cancer related to these exposures has to be appraised. Secondly, the assessment of psychological impact of CT‐scan screening programs among asbestos‐exposed subjects is also required. Am. J. Ind. Med. 52:288–296, 2009. © 2009 Wiley‐Liss, Inc.