bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age distribution and risk factors for Barrett's esophagus by sex at health check-up settings in Japan
Authors: Fukuda Sho , Watanabe Kenta , Kubota Dai , Yamamichi Nobutake , Takahashi Yu , Watanabe Yoshitaka , Adachi Kyoichi , Ishimura Norihisa , Koike Tomoyuki , Sugawara Hideyuki , Asanuma Kiyotaka , Abe Yasuhiko , Kon Takashi , Ihara Eikichi , Haraguchi Kazuhiro , Otsuka Yoshihiro , Yoshimura Rie , Iwaya Yugo , Okamura Takuma , Manabe Noriaki , Horiuchi Akira , Matsumoto Mio , Onochi Kengo , Takahashi So , Yoshida Tatsuki , Shimodaira Yosuke , Iijima Katsunori 
Published: February 2025

Abstract

Background
Given the high prevalence of esophageal adenocarcinoma and Barrett's esophagus (BE), a precancerous lesion, among males, it is important to understand the characteristics of BE by sex to develop an effective endoscopic surveillance program in Japan. The present study examined the age distribution and risk factors for BE in the Japanese health check-up cohort by sex.

Methods
The data set at baseline of our preceding multicenter study, comprising a total of 33,478 individuals who underwent upper endoscopic screening at 17 health check-up institutes across Japan, was utilized. BE and long-segment BE (LSBE) were defined as a columnar-lined esophagus ≥ 1 cm and ≥ 3 cm, respectively. Logistic regression analyses were performed to ascertain the factors associated with BE.

Results
BE was relatively common (10–20%) across all 10-year age groups in men and women. Although the prevalence of LSBE was rare (0.2%), it began to increase at younger ages in men. In the multivariable analysis of the male cohort, while body mass index (BMI) was negatively associated with BE with an adjusted odds ratio (95% confidence interval) of 0.84 (0.74–0.95), waist circumference (WC) was positively associated with 1.26 (1.13–1.41). Furthermore, this association was more pronounced in LSBE. In contrast, no such association was observed between BMI or WC and BE in women.

Conclusion
The nationwide Japanese multicenter study yielded insights into the age distribution of BE in the Japanese population. Furthermore, our findings indicate that a low BMI/high WC represents a significant risk factor for BE in the Japanese male population.
Predicting Trajectories of Everyday Functioning in Adults Aging with HIV Using Latent Growth Mixture Modeling
Authors: Ham Lillian , Roesch Scott , Franklin Donald R. , Ellis Ronald J. , Grant Igor , Moore David J. 
Published: February 2025

Abstract
As the U.S. population of people with HIV (PWH) ages, PWH exhibit high rates of adverse health outcomes including everyday functioning decline. We aimed to (1) identify trajectories of self-reported everyday functioning and (2) examine baseline predictors (demographics, cognitive domains, psychiatric and medical comorbidities, HIV-disease characteristics) of trajectories among PWH. 742 PWH completed up to five semi-annual visits over two years. Latent growth mixture modeling identified a linear 3-class solution with good statistical fit and interpretability. Most PWH (88%) had good baseline functioning with stability. Two classes had elevated baseline functional declines with worsening (7%) or improvement (5%). Greater depressive symptoms and motor skills impairment predicted higher odds of impaired functioning. Having chronic pulmonary disease increased odds of improvement, which may reflect connection to care, while older age increased odds of worsening. Most aging PWH demonstrate stable everyday functioning; however, interventions for depression and motor skills may improve functioning.
Effect of Transcutaneous Tibial Nerve Stimulation in Multiparous Egyptian Women with Vaginal Laxity: A Randomized Controlled Trial
Authors: Hady Doaa A. Abdel 
Published: February 2025

Abstract
Vaginal laxity (VL) is a common symptom of pelvic floor disorder, an underreported condition, and has a substantial impact on women's sex lives and relationships. The study aimed to determine the effect of transcutaneous tibial nerve stimulation (TTNS) on women with VL. Fifty women with vaginal laxity were chosen from an outpatient clinic in Egypt. They were randomly split into two equal categories (A and B). Group A (n = 25) received pelvic floor exercises (PFE), while Group B (n = 25) received TTNS and PFE. Every week, both groups performed three sessions for three months. The outcomes were evaluated both before and following treatment using ultrasound imaging to assess pelvic floor muscle (PFM) function and the Female Sexual Function Index to measure sexual function. Vaginal Laxity Questionnaire (VLQ) were used to examine vaginal looseness. The analysis demonstrated a significant improvement in vaginal laxity in both groups. Post-treatment comparisons revealed a statistically significant difference in VLQ scores and PFM strength between Groups B and A. These findings indicate that TTNS is notably more effective in improving PFM activity and VLQ scores in women with vaginal laxity.
Family Firms and Ethics: Towards a Deeper Understanding of the Determinants of Ethical Decision-Making and Emerging Future Research Pathways
Authors: Kastanakis Minas N. , Magrizos Solon , Kampouri Katerina , Calabrò Andrea 
Published: February 2025

Abstract
The goal of this study is to reveal which contextual factors can shape ethical behaviour and decision-making in family firms (FFs), with the aim to uncover emerging themes that help set the stage for future work on FF ethics. To do so, we conducted an integrative literature review. By systematically collecting, reviewing 90 studies and synthesizing their key findings with prior theoretical foundations in the FF field, we demonstrate how personal and family values, preservation of socioemotional wealth, generation succession and structural factors (e.g. FF size, FF life cycle) can affect ethical decision-making in FFs. We also provide propositions and research pathways to orient future studies.
Exploring Consent to Use Real-World Data in Lung Cancer Radiotherapy: Decision of a Citizens’ Jury for an ‘Informed Opt-Out’ Approach
Authors: Kapadi Arbaz , Turner-Uaandja Hannah , Holley Rebecca , Wicks Kate , Hamrang Leila , Turner Brian , van Staa Tjeerd , Bowden Catherine , Keane Annie , Price Gareth , Faivre-Finn Corinne , French David , Sanders Caroline , Holm Søren , Devaney Sarah 
Published: February 2025

Abstract
An emerging approach to complement randomised controlled trial (RCT) data in the development of radiotherapy treatments is to use routinely collected ‘real-world’ data (RWD). RWD is the data collected as standard-of-care about all patients during their usual cancer care pathway. Given the nature of this data, important questions remain about the permissibility and acceptability of using RWD in routine practice. We involved and engaged with patients, carers and the public in a two-day citizens’ jury to understand their views and obtain decisions regarding two key issues: (1) preferred approaches to consent for the use of RWD within the context of patients receiving radiotherapy for lung cancer in RAPID-RT and (2) how RWD use should be best communicated to patients. Individual views were polled using questionnaires at various stages of the jury, whilst group discussion activities prompted further dialogue about the rationale behind choices of consent. Key decisions obtained from the jury include: (1) an opt-out approach to consent for the use of RWD; (2) the opt-out approach to consent should be informed. Furthermore, it was advised that information and communication regarding the consent process and use of RWD should be accessible, clear and available in a variety of formats. It is important that the consent process for patient data use is underpinned by principles of autonomy and transparency with clear channels of communication between those asking for and giving consent. Moreover, the process of seeking consent from patients should be proportionate to the risks presented from their participation.
Pulmonary Aspergillosis and Low HIES Score in a Family with STAT3 N-Terminal Domain Mutation
Authors: Lima de Souza Suiane , Asano Takaki , Glumoff Virpi , Keskitalo Salla , Pikkarainen Keela , Martelius Timi , Kaustio Meri , Saarela Janna , Kuismin Outi , Lappi-Blanco Elisa , Jartti Airi , Yannopoulos Fredrik , Tiitto Leena , Seppänen Mikko R. J. , Boisson Bertrand , Casanova Jean-Laurent , Varjosalo Markku , Hautala Timo , Chen Zhi 
Published: February 2025

Abstract
Signal transducer and activator of transcription 3 (STAT3) plays a key role in leukocytic and non-leukocytic cells. Germ line mutations in STAT3, which are mainly found in the SH2, DNA binding and transactivation domains, can be loss- or gain-of-function (LOF and GOF). STAT3 N-terminal domain (NTD) mutations are rare, and their biological effects remain incompletely understood. We explored the significance of STAT3 NTD p.Trp37* variant in a patient with chronic pulmonary aspergillosis and a low Hyper-IgE syndrome (HIES) score. In cell culture models, the expression of full-length p.Trp37* allele showed shorter STAT3 protein expression suggesting a re-initiation (Met99 or Met143). STAT3 activity using luciferase reporter assay showed a twofold-increased activity of the STAT3 p.Trp37* STAT3 protein compared with WT STAT3 at basal level and upon IL-6 stimulation. In contrast, the activity of the short pTrp37* peptide (amino acids 1 to 37) was amorphic but without dominant negative (DN) effect on transcriptional activity or STAT3 Tyr705 phosphorylation. The proteins initiated at Met99 and Met143 were surprisingly hypermorphic. In carriers’ peripheral blood mononuclear cells (PBMCs), both WT and mutated STAT3 mRNA were equally present and the global amount of STAT3 protein was not significantly reduced. In stimulated heterozygous carriers’ PBMCs, however, STAT3 Tyr705 phosphorylation and Th17 were reduced but not completely abolished. This suggests a DN effect of an unknown product of the p.Trp37* allele. Transcriptomics analysis of PBMCs from the index revealed selectively distinct gene expression. We conclude that heterozygosity for the NTD p.Trp37* STAT3 mutation defines a novel allelic form of STAT3 deficiency, associated with a chronic pulmonary aspergillosis and minor signs of HIES.
Further Evidence for the Latent Structure and Relationship Between Belief in a Just World and Subjective Well-Being: A Commentary on the Latent Factor Approach by Hafer et al. (2020)
Authors: Donat Matthias , Wolgast Anett 
Published: February 2025

Abstract
Just-world research frequently indicates a relatively strong and positive relation between belief in a just world (BJW) and subjective well-being (SWB). Researchers argue that BJW provides people with beneficial, adaptive functions allowing them to sustain mental health and well-being. Furthermore, BJW is often divided into two dimensions (personal and general BJW) which are usually positively related to each other but also differently to SBW. Hafer et al., Social Justice Research proposed a latent factor approach to investigate the extent to which a common latent factor ‘BJW’ relates stronger to well-being than personal or general BJW. Building upon the approach of Hafer et al., Social Justice Research we propose a second-order-factor approach including first-order factors measured at the latent level using structural equation modeling. We analyzed this approach with two culturally different samples consisting of N = 482 German participants and N = 569 Iranian participants. Our results indicated strong positive relations between the latent second-order factors BJW and SWB and conceptually replicated the results of Hafer et al., Social Justice Research by using an approach that accounts for the measurement errors in the first- and second-order factors. Our findings support the assumptions of Hafer et al., Social Justice Research and the measurement of first- and second-order factors at the latent level and provide possible implications for just-world research.
Parablechnum shuariorum (Blechnaceae), a new fern species from the Cordillera del Cóndor
Authors: Molino Sonia , Zapata José Nicolás , Heal Deli , Testo Weston L. 
Published: February 2025

Abstract

Parablechnum is the most diverse genus in the fern family Blechnaceae, with about 70 species, mainly from Central and South America, the Austropacific, and a few in Africa. Species delimitation in Parablechnum is challenging, and regional studies vary in species recognized. This genus is generally found in humid mid- to high-elevation forests, especially in the Andes. Ecuador is notable for its high species richness, particularly in the poorly explored Cordillera del Cóndor, a sub-Andean range with a distinctive geology contributing to high plant diversity and endemism. Since the early 2000s, botanical expeditions have revealed numerous endemic species, highlighting the region's significance. In 2006, an unusual Parablechnum species was collected in the Cordillera del Cóndor. Here, we describe it as a new species, Parablechnum shuariorum. It grows on sandstone cliffs along small rivers and can be distinguished by its fertile fronds, which are shorter than its sterile ones, and its densely scaly rachis. This species, endemic to the Cordillera del Cóndor, is found at elevations of 900–1,600 m. It is named after the Shuar people, whose lands include the collection sites. Preliminary conservation assessment suggests that P. shuariorum is endangered due to a limited area of occupancy and threats from human activities, such as mining.
Microstructural Analysis of the Dissimilar Weld AL6XN SASS and 2205 DSS Steels Plates
Authors: Rodríguez-Torres José Antonio , López-Morelos Víctor Hugo , Granados-Becerra Heriberto , Reyes-Gasga José 
Published: February 2025

Abstract
Microstructural and chemical analyses of a dissimilar welded joint between AL6XN super austenitic stainless steel and 2205 duplex stainless steel plates by scanning electron microscopy, energy-dispersive X-ray spectroscopy, electron backscatter diffraction, and X-ray diffraction were carried out. Gas-metal arc welding process used ERNiCrMo-3 filler wire and 95Ar, 3%N2, 2%O2 as shielding gas. Voltage, current, and travel speed were set up to a heat input of 1.6 kJ/mm. The analyses were done in the dilution, fusion, and heat-affected zones. The dilution percentage at the AL6XN SASS and the 2205 DSS interfaces yielded 12.97 and 13.75%, respectively. Phase analysis provided insights into microstructural evolution, including twin dissolution, at the HAZ-2205 DSS interface. The formed precipitates were rich in Nb, Mo, Ti, Al and Si. The Vickers microhardness measurements revealed variations attributed to thermal gradients and cooling rates.
The need for clinical, genetic and radiological characterization of atypical polycystic kidney disease
Authors: Righini Matteo , Corsi Cristiana , Sciascia Nicola , Aiello Valeria , Ciurli Francesca , Lerario Sarah , Berti Gian Marco , Montanari Francesca , Conti Amalia , Cristalli Carlotta Pia , Menabò Soara , Caramanna Luca , Tondolo Francesco , Turchetti Daniela , La Manna Gaetano , Capelli Irene 
Published: February 2025

Abstract

Background
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a monogenic disease having a prevalence of 1:400–1000 live births. Depending on kidney imaging, patients can be subdivided into Class 1 (typical) and Class 2 (atypical). The present study aims to provide better assessment of Class 2 patients to help define their family history, together with their clinical and radiological characteristics.

Methods
One hundred twenty-four PKD patients with abdominal Magnetic Resonance Imaging (MRI) for the staging of ADPKD, were retrospectively analyzed, aiming to focus on Class 2 ADPKD patients. Total kidney volume and total cyst volume were evaluated, while also assessing their clinical and genetic characteristics.

Results
Twelve patients fulfilled the Mayo criteria for Class 2 ADPKD (two Class 2B and ten Class 2A). Extrarenal involvement was observed in 66.7% of cases, but only two subjects presented an estimated Glomerular Filtration Rate (eGFR) < 60 mL/min/1.73 m2. A positive family history for cystic disease was more frequent compared to other published cohorts. Only 8.3% tested positive for a likely pathogenic mutation in the PKD1 gene. Class 2B patients showed a lower height-adjusted total kidney volume, with a lower percentage of total cyst volume.

Conclusion
Based on our results, atypical ADPKD does not represent an uncommon condition, being present in about 10% of MRI-evaluated patients diagnosed with ADPKD. Genetic tests are frequently negative for PKD1/PKD2, and total cyst volume and residual tissue volume do not increase the prognostic value of MRI in patients with these radiological characteristics. Other tools are needed to better characterize their kidney prognosis.

Graphical abstract
Technology-enabled organization designs for tackling the grand challenges: the case of Giga
Authors: Tatarinov Katherine , Ambos Tina C. 
Published: February 2025

Abstract
This Point of View article discusses how technology enables new maverick organization designs for tackling the grand challenges. Organizations with maverick designs, those that deviate from the norm, are disrupting the status quo, but the longevity of these types of designs is often limited. This is particularly problematic when organizations aim to address grand challenges, as these require long-term vision and continuous collaboration. The grand challenges context requires an evolving ecosystem of stakeholders to work together creating a meta-organization. In this article, we introduce the case of Giga, a maverick organization design formed out of two United Nations organizations, that aims to connect all schools in the world to the internet. Giga uses technology to enable a new way of working and collaborating across sectors to create revolutionary pathways for scaling school connectivity. We draw multiple learnings from this distinctive case, illustrating how novel organizing forms enabled by technology can effectively navigate the design dilemmas that often confound organizations: bridging the gap between bureaucracy and new venture; balancing control and orchestration; and harmonizing technology with human principles. The case demonstrates the effectiveness of technology-enabled organization designs and their potential to increase the longevity of maverick approaches by showcasing how a technology-based thematic can be used as an evolving guiding principle; how an open-source approach can aid orchestration and build a meta-organization; and how technology can serve as a humanizing principle to result in a lasting narrative.
Scaling or growing agile? Proposing a manifesto for agile organization development
Authors: Bremer Constantin , Rylander Eklund Anna , Elmquist Maria 
Published: February 2025

Abstract
In the face of today’s world of uncertainty, many organizations aim for more flexible and less hierarchical forms of organizing. Relatedly, management scholars and consultants have increasingly taken stock of the agile concept, advocating a scaling of agile teams and their maverick practices to the organizational level. Considering four common challenges with organization-level agile in practice, we outline an alternative trajectory for agile in the context of organization design. This alternative trajectory builds on the notion of growing (rather than scaling) agile and is rooted in the Manifesto for Agile Software Development as the philosophical anchor of the agile movement. In this paper, we describe the journey of a Swedish software company along which we highlight the discrepancies in assumptions about uncertainty and people between manifesto agile and large-scale agile. Based on our case analysis, we propose a Manifesto for Agile Organization Development with four associated values, bringing the original Agile Manifesto and its mindset of trusting people to solve problems together locally to the organizational level. We further articulate five principles for agile organization development and illustrate through our case how bringing them to life can help address the common challenges of organization-level agile. Rather than a blueprint, our manifesto, and its associated values and principles are intended as an alternative basis for developing and discussing what manifesto agile means at an organizational level and how it can be turned into practice(s) in local contexts.
A stratigrapher’s reflecions on climate change and energy transition
Authors: Carpio Mariano Marzo 
Published: February 2025

Abstract
This article consists of two well-differentiated parts. The first, based on a bibliographic analysis, tries to position this current episode of global warming within the framework of the geological history of climate change. The conclusion is clear and in line with the scientific consensus. Greenhouse gas emissions linked to human actions are the main cause of global warming. Given this situation, we can speculate about the future climate evolution of the “Anthropocene”. Unfortunately, such projections in the scientific literature paint a bleak picture. Paradoxically, future predictions take us back millions of years in geological history, placing humanity in unknown territory. Accordingly, we must ask ourselves what we can do to adjust the global thermostat. A first optimistic reflection is that the very fact that humans are the cause of the problem opens a window of hope. If global warming were due to natural causes linked to astronomical phenomena, to the internal dynamics of the planet, or to its evolution, we could do little or nothing to remedy our current climate situation. However, if we are the main cause of the crisis, we have the capacity to resolve it. This consideration, in turn, leads us to the second part of this article which comprises a series of personal reflections on the nature of the so-called energy transition and its main lines of action.
Size and Illumination Matters: Local Magnetic Actuation and Fluorescence Imaging for Microrobotics
Authors: Huaroto Juan J. , Misra Sarthak 
Published: February 2025

Abstract
Combining local magnetic actuation with fluorescence imaging modalities promises to introduce significant advances in microrobotic-guided procedures. This review presents the advantages and challenges of this approach, emphasizing the need for careful design considerations to optimize performance and compatibility. Traditional microrobotic actuation systems rely on bulky electromagnets, which are unsuitable for clinical use due to high power requirements and limited operational workspace. In contrast, miniaturized electromagnets can be integrated into surgical instruments, offering low power consumption and high actuation forces at the target site. Fluorescence imaging modalities have been explored in microrobotics, showcasing spatiotemporal resolution and the capability to provide information from biological entities. However, limitations, such as shallow penetration depth and out-of-focus fluorescence, have motivated the development of advanced techniques such as two-photon microscopy. The potential of two-photon microscopy to overcome these limitations is highlighted, with supporting evidence from previous studies on rat tissue samples. Current challenges in optical penetration depth, temporal resolution, and field of view are also addressed in this review. While integrating miniaturized electromagnets with fluorescence imaging modalities holds the potential for microrobotic-guided procedures, ongoing research and technological advancements are essential to translating this approach into clinical practice.