bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Morphological Study of Cultured Endodermal Cells of Chick Embryo: Characteristics of Adhesion, Spreading and Locomotion
Authors: Garcia C. , Arias M. , Villar J. M. 
Published: June 2007

SummaryA study is made of the morphological characteristics of the endodermic cells of the stage 5 chick embryo by means of in vitro cell culture techniques. The scanning electron microscope revealed that the endodermic cells in cultures were rounded, tended to be smooth and had few blebs and microvilli. Regarding cell projections typical of culture cells, such as filopodia, lamellipodia and pseudopodia, there was a noteworthy scarcity after 12 h growth, although greater cellular activity was observed at 24 h, characterized by the presence of filopodia and an ability of the cells to form clusters on the substratum. These facts show the morphological and adhesion movements of the endodermal cells studied to be related mainly with the presence of filopodia as the most abundant cell projections.
Ultrastructure of the Carotid Body of the Goat
Authors: Abdel‐Magied E. M. , Taha A. A. M. 
Published: June 2007

SummaryThe carotid body of the goat was found to be a small oval or rounded parenchymatous organ. It was characterized by its profound vascularity. Delicate septa divided the parenchyma into small feebly denned lobules. Electron microscopy revealed that the parenchyma comprised type I cells, type II cells, nerve endings, axons and fenestrated dilated capillaries. Type I cells were characterized with electron dense‐cored vesicles. They showed variations in size and concentration of the dense‐cored vesicles and number of mitochondria. The possibility that these variations are reflections of different stages of activity is discussed. Type II cells were less numerous than type I cells, relatively small and devoid of dense‐cored vesicles. They usually surrounded small groups of type I cells and associated nerve endings and axons. Presumptive afferent nerve endings characterized with many clear vesicles, occasional large granular vesicles and varying numbers of slender mitochondria, lay apposed to type I cells. Nerve endings of this kind showed afferent and efferent synaptic junctions with type I cells. Presumptive sympathetic efferent endings were occasionally seen within the lobules but never lay apposed to type I cells or afferent nerve ending.
Feinstruktur der Trigeminuskerne vom Haushuhn
Authors: Hummel G. , Kressin M. , Ruhrig S. 
Published: June 2007

SummaryThe trigeminal nerve nuclei are examined light‐ and electron‐microscopically in the adult domestic fowl. The nucleus sen‐sibilis principalis nervi trigemini is formed by scarce, mediumsized, round‐to‐ovoid polygonal neurons. The Nissl bodies are concentrated around the nucleus and consist of short cisterns of the rough endoplasmic reticulum densely bordered with ribosomes. The nucleus tractus spinalis nervi trigemini extends to the first segments of the cervical cord. The rostral part of the nucleus is characterized by medium‐sized polygonal neurons. Their cell bodies are densely packed with coarse Nissl bodies. Small multiforme cell types with large nuclei frequently showing two nucleoli predominate in the caudal part. The motorical main portion, nucleus motorius nervi trigemini consists of medium‐sized as well as great polygonal neurons. The accessory portion, nucleus motorius dorsalis nervi trigemini, consists of medium‐sized polygonal neurons. Both nuclei show the typical motoneuron cytomorphology. In the neuropil, the axodendritic synapses can be differentiated into five types. Occasionally, densely packed glial lamellae and giant mitochondria occur.
Study of ACTH‐immunoreactive Cells after Transplantation of Neonatal Adrenal Glands into Adult Adrenalectomized Rats
Authors: Sarria R. , Losada J. , Oliver F. Doñate 
Published: June 2007

SummaryThe removal of the adrenal glands produced a great increase in the number and size of the cytoplasmic processes of the ACTH‐immunoreactive cells that sometimes establish contact with those of the neighbouring immunoreactive cells. In addition, in this experimental group, the ACTH‐cell percentage and the mean cell, cytoplasmic, and nuclear areas were greatly increased in comparison with those found in control animals. Several regenerated adrenocortical nodules were observed in the small‐bowel segment of rats transplanted with neonatal adrenal glands. The percentage and morphometrical values of the pituitary ACTH‐reactive cells of this experimental group, although slightly increased relative to the rats with intact adrenals, were greatly decreased in relation to those of the adrenalectomized animals.It is concluded that the neonatal adrenal tissue regenerated after its transplantation into adult rats, a process that modified the percentage, the morphological characteristics, and the morphometrical values of the ACTH‐immunoreactive cells of the adrenalectomized rats.
Histomorphologic and Histochemical Characteristics of Carpal Glands (Glandulae Carpeae) in Domestic Swine (Sus scrofa domesticus) and Wild Swine (Sus scrofa ferus)
Authors: Hraste A. , Stojković R. 
Published: June 2007

SummaryInvestigations were carried out on samples from carpal glands of domestic and wild swine of different ages. The anatomic position of carpal glands is identical in domestic and wild swine. Glandular acini in domestic swine are bigger and more scarce than in wild swine. LDH activity is more intense in wild swine, while the activity of the investigated diaphorases is almost even. The activity alkaline and acid phosphatase is stronger in domestic swine, while the activity of non‐specific esterases is present only in wild animals. The more or less manifest presence of all investigated enzymes indicates that carpal glands in domestic and wild porcine specimens are very active metabolically. Regarding the intensity of enzymatic reactions, some differences are probably due to different sexual maturity, as well as to the method of feeding and housing in these groups of animals.
PASSIVE CUTANEOUS ANAPHYLAXIS WITH GUINEA‐PIG AND RABBIT ANTIBODIES TO PENICILLIN DERIVATIVES
Authors: Cronin A. E. 
Published: June 2007

SummaryPassive cutaneous anaphylaxis (PCA) was elicited with penicillin‐treated serum, but not with penicillin itself. Although the intravenous injection of penicillin before challenge prevented systemic anaphylaxis, PCA was not inhibited in this way.Penicilloyl‐polylysine and dialysed penicillin‐treated rabbit serum produced positive PCA reactions in animals sensitized with serum from a guinea‐pig which had been immunized with penicillin‐treated homologous serum. This confirmed that penicilloyl compounds are important antigenic determinants derived from penicillin.
Hemorrhagic and Necrotic Leg Ulcers in the Elderly*
Authors: Kinmont P. D. C. , McCallum D. I. 
Published: June 2007

SummaryOne hundred patients with leg ulcers or gangrene were investigated to determine whether any showed signs of any of the stages of giant cell arteritis. Thirty patients of 50 or more years of age with E.S.R. over 45 mm./hour, were selected for further investigation as suspects. The appearance of the patients and the character of their ulcers are described. Haematological and biochemical findings are contrasted with a selection from the control group, in the former there was frequent disturbance of the globulin/albumin ratio, and increase of the globulin fractions. No cryoglobulins were detected. An attempt was made to piece together the sequence of events from sections of the leg arteries of 50 patients. It is suggested that there may be similarities between some stages of Mönckeberg's sclerosis and giant cell arteritis.The role, of trauma is discussed. Many patients dated the onset of their symptoms to a severe injury and it is suggested that damage to muscle collagen may precipitate giant cell arteritis or an allied condition just as sunlight may precipitate cranial arteritis.
Bowen's Disease: A Clinical and Histological Re‐evaluation1
Authors: Hunter G. A. , Donald G. F. , Burry J. N. 
Published: June 2007

SummaryBrief reference is made to the original papers of Bowen and of Darier, and the later significant developments in our understanding of Bowen's Disease. The wide variation in clinical appearance is emphasized. The involvement of pilosebaceous follicles in the process, and the importance of this factor in planning treatment are emphasized.
Photo‐Allergic Contact Dermatitis from Halogenated Phenolic Compounds1
Authors: Burry J. N. 
Published: June 2007

SummaryThe clinical patterns of photo‐allergic contact dermatitis from several halogenated phenolic compounds which have been recorded in England, United States of America and Australia are described and discussed. Both transient and persistent light reactions have been seen in each country. The variability of clinical presentation resulted from the different ways in which the photo‐allergens were applied, either in soaps or in local medicinal preparations such as antiseptic or antifungal creams. Both the reactivity of each photo‐allergen and the availability of ultra‐violet light to cause it to react are important. The different clinical patterns which should arouse suspicion of photo‐allergic contact dermatitis are listed.It is suggested that these variable clinical pictures are essentially the result of the same biochemical mechanism and that photo‐allergic dermatitis, whether it occurs at the area of contact or at a distance, is the result of changes at the shin site in conjunction with immunological changes and not as the result of immunological changes akin to autosensitization.
Finesse in the Local Surgical Treatment of Malignant Melanoma*
Authors: Gibson E. W. 
Published: June 2007

Summary

. The primary treatment of malignant melanoma is surgical and the most important single factor in cure is adequate local excision.
. Adequate local excision, may mean radical surgery but not necessarily mutilation and disfigurement.
. Local excision will always include clinically involved lymph nodes (if operable) and will also on occasions include clinically uninvolved nodes.
. Recommendations on local excision are made specifically in regard to adequacy in lateral extent and in depth.
. The value of frozen section in determining treatment is mentioned.
. The rationale of prophylactic lymph node dissection is discussed and an attempt made to establish the place of prophylactic dissection in treatment in the light of present knowledge.
. A series of patients with malignant melanoma demonstrating these principles is demonstrated.
Incidence of Skin Cancer in Japan
Authors: Miki Yoshtharu 
Published: June 2007

SummarySunlight had no outstanding effect upon the incidence of skin cancer among Japanese, although some effect of sunlight could be demonstrated by geographic and occupational factors. The lower incidence of skin cancer among Japanese in comparison with Caucasians was probably due to the higher degree of pigmentation of the skin among Japanese, which protects the skin against the carcinogenic effect of sunlight.Even though Japanese were less susceptible to solar carcinogenesis than Caucasians, the carcinogenic effects of bum scars, traumatic scars or radiodermatitis were more evident on comparison with Caucasians living in similar latitudes.
Nodular Dermal Allergide of Gougerot
Authors: Geller Mario , Fraga Sylvio , Schaffel Waldemar , Roimicher Samuel , Gomes Edgard Magalhaes 
Published: June 2007

SUMMARYThe authors present the clinical, histological and laboratory findings in a case of cutaneous necrotizing vasculitis which fits the picture of Gougerot's nodular dermal allergide. They discuss the classification of dermal vasculitis, and the reasons for regarding it as a hypersensitivity reaction.
Vitiligo and Its Treatment
Authors: El‐Mofty Abdel Monem , Nada Mohamed M. 
Published: June 2007

SUMMARYThe results of the treatment of vitiligo with psoralens alone, psoralens combined with oral and/or local corticosteroids, and corticosteroids alone in a series of 259 vitiligo patients are reported. Psoralens alone with solar and/or ultraviolet irradiation proved to be the most reliable and safe therapeutic agent available. Although oral corticosteroids enhance the pigmentary response produced by psoralens and intralesional injection of corticosteroids may be of a beneficial effect in some cases, they cannot be the determining agent in a therapeutic modality in vitiligo. Topical application of corticosteroids, through helping in softening and thinning of the hyperkeratotic thickened skin brought about by repeated irradiation, may be of help in some cases, but used alone it did not induce any repigmentary response.
Prescribing by Six Australian Dermatologists A Pilot Study*
Authors: Green Allen C. , Wallace Malcolm G. 
Published: June 2007

SUMMARYSix Australian dermatologists agreed to participate in a pilot study on their prescribing habits.The many medicaments they prescribed in their private practices as pharmaceutical benefits under the National Health Act 1953–1973 during the months of October, 1972, and February, 1973, are tabulated and discussed.The preparations most often ordered were classified into groups which included antibiotics, sulphonamides, antihistamines, drugs acting on the nervous system, corticosteroids, fungistatics, antimalarials and topical applications.Apart from the selection of tetracyclines and betamethasone in topical applications, the results are interesting because they show diversity rather than similarity in the approach to dermatological treatment by these six dermatologists. The differences in selecting either griseofulvin of nystaatin are given explanation.
OBSERVATIONS ON THE INTERACTIONS BETWEEN NON‐STEROID ANTI‐INFLAMMATORY AGENTS AND CORTICOSTEROIDS*
Authors: Gaylarde P. M. , Brock A. P. , Sarkany I. 
Published: June 2007

SummaryWe have shown that corticosteroids and non‐steroid anti‐inflammatory agents suppress the increase in skin thickness in response to irritants applied to guinea pig skin. The combination of salicylic acid with corticosteroids and acetyl salicylic acid with hydrocortisone results in an antagonistic reduction of their anti‐inflammatory activities. Indomethacin, in contrast, acts synergistically with corticosteroids.Sodium salicylate also suppresses DNA synthesis of human skin in vitro and hydrocortisone sodium succinate is able to abolish this suppression. This result, together with the results of trials on human volunteers, suggests that our findings may be relevant to the use of preparations containing combinations of non‐steroid and steroid anti‐inflammatory drugs in the clinical situation.The antagonism between salicylates on the one hand and indomethacin and steroids on the other, has been demonstrated by our work on the skin of man and the guinea pigs. A similar effect had been previously described in adjuvant induced arthropathy in the rat. These findings should alert clinicians who use anti‐inflammatory agents in various combinations, to the possible reduction of clinical effect due to antagonism between salicylates and other anti‐inflammatory drugs.
ROLE OF LYMPHOCYTE TRANSFORMATION IN DRUG ALLERGY*
Authors: Sarkany I. , Gaylarde P. M. 
Published: June 2007

SummaryThe role of lymphocyte transformation in the diagnosis of drug allergy is reviewed. Of 165 patients with clinically suspected drug allergy, 22 (13.3%) gave a positive lymphocyte transformation result. Reasons for this low incidence of positive reactions are put forward.Lymphocyte transformation testing in patients with halothane related hepatitis was uniformly negative in 29 patients and this test has not been found useful in the diagnosis of this condition as against viral hepatitis.We have also found that a number of drugs including co‐trimoxazole, piperazine, chlorpromazine, promethazine and griseofulvin inhibit DNA synthesis in lymphocytes in vitro. This may be the result of inhibition of transformation of lymphocytes, a cytotoxic effect or the effect of inhibition of thymidine incorporation. The in vitro suppression of DNA synthesis in lymphocytes by co‐trimoxazole, rifampicin and miconazole has been suggested as being related to their possible in vivo immunosuppressive activity.
TREATMENT OF CUTANEOUS CANDIDIASIS: A DOUBLE BLIND, PARALLEL COMPARISON OF SULCONAZOLE NITRATE 1% CREAM AND CLOTRIMAZOLE 1% CREAM
Authors: Rajan V. S. , Thirumoorthy T. 
Published: June 2007

SummaryFifty‐seven subjects with clinically proven cutaneous candidiasis were entered into a double blind, parallel, randomized comparison of sulconazole nitrate 1 % cream applied once daily and clotrimazole 1% cream applied twice daily. The duration of active treatment was three weeks with a four‐week follow‐up without treatment for those clinically cured at Week 3 to determine relapse rate.Sixteen patients failed to complete the study, twelve for reasons unrelated to study medication and four with suspected adverse reactions to sulconazole nitrate.There were no statistically significant differences between the two treatments when considering efficacy parameters (which included KOH microscopic preparation, fungal culture and clinical evidence of fungal infection).There were seven sulconazole nitrate and three clotrimazole treatment failures (ascertained by positive KOH microscopic preparation) at Week 3, this difference not being statistically significant. There were no relapses at the four‐week follow‐up in patients clinically cured after three weeks active treatment.
THE SIGN OF LESER‐TRÉLAT
Authors: Czarnecki D. B. , Rotstein H. , O'Brien T. J. , Lyall I. G. , Hanna M. J. D. 
Published: June 2007

SummaryThe sign of Leser‐Trélat is the sudden appearance and rapid increase in number of seborrhoeic keratoses on previously normal skin. It is a cutaneous marker of internal malignancy. Two patients exhibiting this sign are described and a further thirty‐seven have been found in the medical literature. The main features of these patients are reviewed.
UV‐B PHOTOTHERAPY FOR PITYRIASIS LICHENOIDES
Authors: Tham Siew Nee 
Published: June 2007

SUMMARYEighteen patients with long standing pityriasis lichenoides were treated with UV‐B phototherapy. Fourteen patients (82.4%) had a good response to the treatment with complete clearance in nine patients (53.0%) and more than 90% clearance in five patients (29.4%). Three patients (17.6%) did not clear but all had definite improvement. One patient defaulted after 10 treatments. Of the 14 patients who cleared, 12 were followed up for a period ranging from six months to three years and five months. Six patients remained clear. Four patients had a few recurrent lesions which did not necessitate re‐treatment, and three of these patients eventually cleared spontaneously. Two patients who had relapses which cleared on re‐treatment with UV‐B phototherapy subsequently remained clear after a further six months and 17 months follow‐up, respectively.
GREASY SCALING PITYRIASIS AMIANTACEA AND ALOPECIA: A SYNDROME IN SEARCH OF A CAUSE
Authors: Keipert James A. 
Published: June 2007

SUMMARYA syndrome consisting of localized areas of greasy scaling of the scalp, partial alopecia, pityriasis amiantacea and groups of hairs in the lesions of pityriasis amiantacea pulling out easily, occurs occasionally in children. Some of the features are suggestive of tinea capitis but repeated fungal cultures are negative. The disorder is slow to respond to non specific treatment, but may have responded slowly to griseofulvin in two patients reported here. This syndrome is described and discussed, and it is postulated that a satisfactory cause has not been found for this unusual disorder.
THE FREE ANDROGEN INDEX AND MILD HIRSUTISM
Authors: Moses R. , Archibald L. , Egri S. , Thiele H. 
Published: June 2007

SummaryThe plasma testosterone was abnormal in only 11% of patients with mild hirsutism. However, a derived product, the free androgen index, was abnormal in 66% of cases and appears useful as a discriminating test.
DERMATITIS DUE TO CHROMATE IN CEMENT PART II. INCIDENCE OF CEMENT DERMATITIS IN AUSTRALIA
Authors: Freeman Susanne 
Published: June 2007

SummaryInformation has been obtained from 188 Australian dermatologists relating to allergic contact dermatitis due to cement. 54 cases of chromate‐positive cement dermatitis were recorded in twelve months from May 1985.It is suggested that ferrous sulphate should be added to cement to prevent chromate sensitivity in cement and concrete workers.
ZYGOMYCOSIS IN A TATTOO, CAUSED BY SAKSENAEA VASIFORMIS
Authors: Parker Colin , Kaminski Geraldine , Hill Dudley 
Published: June 2007

SummarySubcutaneous zygomosis, caused by Saksenaea vasiformis developed In the forearm of a 25 year old male in the area of a tattoo performed seven years previously.The spectrum of disease caused by S. vasiformis can range from rapidly progressive disseminated infection in immunosuppressed persons, to disease of slow onset and limited spread where immune function is intact.Several species of zygomycetes can cause human disease. Tissue invasion is by broad mycelia which stain well with H & E. Species identification can only be achieved by inducing the isolate to produce sporangia, and in the case of S. vasiformis special techniques are necessary. Even so, long delays may be experienced before producing the typical long necked vase shaped sporangium of S. vasiformis.In the case described, treatment with amphotericin B was successful.
PSORIASIFORM DRUG ERUPTION DUE TO GLIBENCLAMIDE
Authors: Goh C. L. 
Published: June 2007

SummaryA 49 year old Indian female with the clinical and histological features of a psoriasiform eruption due to glibenclamide, an oral hypoglycaemic agent, is described. The eruption resembled that caused by some beta blockers. The condition did not improve with topical tar treatment but cleared within six weeks after withdrawal of glibenclamide. Cutaneous reactions to glibenclamide are uncommon and there has been no previous report of a psoriasiform eruption due to this drug.
HOME TREATMENT OF SKIN CANCER AND SOLAR KERATOSES
Authors: Green Adele C. , Beardmore Graeme L. 
Published: June 2007

SummaryParticipants in a community survey of skin cancer and solar keratoses were asked about their use of home remedies for these lesions. There were 164 persons aged between 20 and 69 years at high risk who said they treated these lesions themselves (7.8% of those surveyed). Half of the agents used were naturopathic and of these Euphorbia peplus was unanimously considered an effective treatment. Aloe vera was the most popular remedy and paw paw and creams such as lanolin were also popular despite their generally perceived lack of efficacy. Most of the self‐treaters were at high risk of skin cancer and thus the danger of this home treatment is the likely failure to recognize invasive disease. Close medical supervision of the treatment of actinic lesions remains essential.
EPIDERMODYSPLASIA VERRUCIFORMIS ASSOCIATED WITH MULTIPLE SQUAMOUS CELL CARCINOMAS
Authors: Salmon Robert , Thompson Carol , Rose Barbara , Kelly Graham , Cossart Yvonne 
Published: June 2007

SummaryIn this report a 48 year old patient with non‐familial epidermodysplasia verruciformis is described. The disease had persisted for 36 years and had been incorrectly diagnosed as psoriasis on a number of occasions. From 1980 the patient developed numerous skin tumours, including five squamous cell carcinomas (SCCs) and a basal cell carcinoma, on the sun‐exposed areas of his body. In June 1986 a poorly‐differented SCC, presumed to be a secondary deposit from one of the previously resected skin cancers, was excised from his left parotid gland. A recurrence of this invasive SCC was resected two months later. Despite several courses of radiotherapy and treatment with transfer factor the tumour continued to enlarge, and the patient died from local effects in December 1987. The clinical, virological and immunological criteria used to establish the diagnosis are presented.