bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shaping Brassinosteroid Signaling through Scaffold Proteins
Authors: Guo Boyu , Kim Eun-Ji , Zhu Yuxian , Wang Kun , Russinova Eugenia 
Published: April 2024

Abstract
Cellular responses to internal and external stimuli are orchestrated by intricate intracellular signaling pathways. To ensure an efficient and specific information flow, cells employ scaffold proteins as critical signaling organizers. With the ability to bind multiple signaling molecules, scaffold proteins can sequester signaling components within specific subcellular domains or modulate the efficiency of signal transduction. Scaffolds can also tune the output of signaling pathways by serving as regulatory targets. This review focuses on scaffold proteins associated with the plant GLYCOGEN SYNTHASE KINASE3–like kinase, BRASSINOSTEROID-INSENSITIVE2 (BIN2), that serves as a key negative regulator of brassinosteroid (BR) signaling. Here, we summarize current understanding of how scaffold proteins actively shape BR signaling outputs and cross-talk in plant cells via interactions with BIN2.
Rice transcription factor OsWRKY37 positively regulates flowering time and grain fertility under copper deficiency
Authors: Ji Chenchen , Li Haixing , Ding Jingli , Yu Lu , Jiang Cuncang , Wang Chuang , Wang Sheliang , Ding Guangda , Shi Lei , Xu Fangsen , Cai Hongmei 
Published: April 2024

Abstract
Efficient uptake, translocation, and distribution of Cu to rice (Oryza sativa) spikelets is crucial for flowering and yield production. However, the regulatory factors involved in this process remain unidentified. In this study, we isolated a WRKY transcription factor gene induced by Cu deficiency, OsWRKY37, and characterized its regulatory role in Cu uptake and transport in rice. OsWRKY37 was highly expressed in rice roots, nodes, leaf vascular bundles, and anthers. Overexpression of OsWRKY37 promoted the uptake and root-to-shoot translocation of Cu in rice under −Cu condition but not under +Cu condition. While mutation of OsWRKY37 significantly decreased Cu concentrations in the stamen, the root-to-shoot translocation and distribution ratio in brown rice affected pollen development, delayed flowering time, decreased fertility, and reduced grain yield under −Cu condition. yeast one-hybrid, transient co-expression and EMSAs, together with in situ RT-PCR and RT-qPCR analysis, showed that OsWRKY37 could directly bind to the upstream promoter region of OsCOPT6 (copper transporter) and OsYSL16 (yellow stripe-like protein) and positively activate their expression levels. Analyses of oscopt6 mutants further validated its important role in Cu uptake in rice. Our study demonstrated that OsWRKY37 acts as a positive regulator involved in the uptake, root-to-shoot translocation, and distribution of Cu through activating the expression of OsCOPT6 and OsYSL16, which is important for pollen development, flowering, fertility, and grain yield in rice under Cu deficient conditions. Our results provide a genetic strategy for improving rice yield under Cu deficient condition.
Dynamic Perturbation
Authors: Mennuni Alessandro , Rubio-Ramírez Juan F , Stepanchuk Serhiy 
Published: April 2024

Abstract
We present a novel algorithm called Dynamic Perturbation for solving large-scale macroeconomic models. Our approach involves computing first-order Taylor expansions of the policy functions along the entire equilibrium path. This method applies to a wide range of models and offers significantly higher accuracy than traditional perturbation approaches. Remarkably, even when utilising first-order approximations, our method can effectively handle models with strong nonlinearities and occasionally binding constraints, such as the zero lower bound.
A Qualitative Exploration of Social Workers’ Job Preparedness in Law Enforcement Agencies
Authors: Rhodes Dasha J , Ost Jam H , Gandarilla-Javier Sharon 
Published: April 2024

Abstract
Police agencies are increasingly integrating social workers in response to more calls regarding mental health and social welfare needs. Limited research captures the experiences and needs of social workers in law enforcement agencies. This article explores social workers’ job preparedness through a qualitative phenomenological study. The study includes a semistructured interview with 40 participants from across the nation to identify factors for job preparedness, social workers’ experiences, and perceived areas for development. As a result, seven themes emerged: exposure, a lack of understanding, unpredictability, programmatic growth and support, systemic challenges, assessment needs, and workplace culture. Most participants revealed that they did not feel prepared for their role but shared instances of helpful experiences, insights, and needs of the profession. The participants highlighted the need for social workers to continue to educate themselves to better prepare for the populations they serve. Several implications are discussed to address and enhance the needs of the profession.
Predictive Models to Assess Risk of Persistent Opioid Use, Opioid Use Disorder, and Overdose
Authors: Song Sophia L. , Dandapani Hari G. , Estrada Rodolfo S. , Jones Nicholas W. , Samuels Elizabeth A. , Ranney Megan L. 
Published: April 2024

BackgroundThis systematic review summarizes the development, accuracy, quality, and clinical utility of predictive models to assess the risk of opioid use disorder (OUD), persistent opioid use, and opioid overdose.MethodsIn accordance with Preferred Reporting Items for a Systematic Review and Meta-analysis guidelines, 8 electronic databases were searched for studies on predictive models and OUD, overdose, or persistent use in adults until June 25, 2023. Study selection and data extraction were completed independently by 2 reviewers. Risk of bias of included studies was assessed independently by 2 reviewers using the Prediction model Risk of Bias ASsessment Tool (PROBAST).ResultsThe literature search yielded 3130 reports; after removing 199 duplicates, excluding 2685 studies after abstract review, and excluding 204 studies after full-text review, the final sample consisted of 41 studies that developed more than 160 predictive models. Primary outcomes included opioid overdose (31.6% of studies), OUD (41.4%), and persistent opioid use (17%). The most common modeling approach was regression modeling, and the most common predictors included age, sex, mental health diagnosis history, and substance use disorder history. Most studies reported model performance via thecstatistic, ranging from 0.507 to 0.959; gradient boosting tree models and neural network models performed well in the context of their own study. One study deployed a model in real time. Risk of bias was predominantly high; concerns regarding applicability were predominantly low.ConclusionsModels to predict opioid-related risks are developed using diverse data sources and predictors, with a wide and heterogenous range of accuracy metrics. There is a need for further research to improve their accuracy and implementation.
Management Changes After Echocardiography Are Associated With Improved Outcomes in Critically Ill Children*
Authors: Ip Pui Yin Florence , Periasamy Uvaraj , Staffa Steven J. , Zurakowski David , Kantor David B. 
Published: April 2024

OBJECTIVES:
To evaluate management changes and outcomes in critically ill children after formal echocardiography.

DESIGN:
Retrospective cohort study between January 1, 2011, and December 31, 2020.

SETTING:
Tertiary care children’s hospital.

PATIENTS:
Patients from 1 to 18 years who had formal echocardiography within 72 hours of ICU admission and who were intubated and on vasoactive infusions at the time of the study. Patients were stratified into two cardiac function groups: 1) near-normal cardiac function and 2) depressed cardiac function.

METHODS:
Clinical variables were abstracted from the electronic medical record and placed in time sequence relative to echocardiography. Vasoactive and fluid management strategies in place before echocardiography were associated with markers of tissue perfusion and volume overload. Management changes after echocardiography were characterized and associated with outcomes.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Among patients eventually found to have depressed cardiac function, the use of vasoconstrictors was associated with worse lactate clearance and oxygen extraction ratio. Use of vasoconstrictors in this cohort was also associated with a more liberal fluid management strategy, evidence of increased lung water, and a worse Spo
2/Fio
2. An echocardiogram demonstrated depressed cardiac function was likely to be followed by management changes that favored inotropes and more conservative fluid administration. Patients with depressed cardiac function who were switched to inotropes were more likely to be extubated and to wean off vasoactive support compared with those patients who remained on vasoconstrictors.

CONCLUSIONS:
Among patients with depressed cardiac function, alterations in management strategy after echocardiography are associated with shortened duration of intensive care interventions.
Corporate social responsibility supercharged: greening employee behavior through human resource management practices and green culture
Authors: Aukhoon Mubashir Ahmad , Iqbal Junaid , Parray Zahoor Ahmad 
Published: April 2024

PurposeThe primary objective of this study was to understand the impact of Corporate Social Responsibility on Employee Green Behavior, examining the mediating role played by Green Human Resource Management Practices and the moderating influence of Employee Green Culture.Design/methodology/approachTo accomplish this, a careful research approach was taken, using a thoughtfully designed random sampling method to encompass 300 banking employees, ensuring a robust representation of the diverse workforce in the banking sector.FindingsThe empirical findings identified green human resource management practices as a pivotal mediator and employee green culture as a significant moderator. It elucidated how the strategic implementation of green human resource management practices can act as an amplifier, strengthening the positive effects of corporate social responsibility on employee green behavior. This insight underscores the strategic importance of aligning human resource practices with sustainability goals to further enhance the environmental consciousness of employees. It was revealed that the presence of a nurturing organizational culture, one that encourages and supports environmentally responsible behaviors can significantly bolster the association between corporate social responsibility and green behavior among employees.Originality/valueThese findings underscore the essential role of organizational culture as a catalyst for the successful implementation of corporate social responsibility initiatives and the cultivation of a sustainable corporate ethos. This comprehensive research underscores the profound significance of corporate social responsibility, green human resource management practices and employee green culture in fostering and promoting environmentally responsible behaviors within the banking industry. These findings hold substantial implications not only for businesses but also for policymakers.
Development of a digital transformation maturity model for the construction industry
Authors: Han Yanhu , Du Haoyuan , Zhao Chongyang 
Published: April 2024

PurposeDigital transformation is crucial for achieving high-quality development in the construction industry. Assessing the industry's digital maturity is an urgent necessity. The Digital Transformation Maturity Model is a potential tool to systematically evaluate the digital maturity levels of various industries. However, most existing models predominantly focus on sectors such as the Internet and manufacturing, leaving the construction industry comparatively underrepresented. This study aims to address this gap by developing a maturity model tailored specifically for digital transformation within the construction industry.Design/methodology/approachThis study leverages the Capability Maturity Theory and integrates the unique characteristics of the construction industry to construct a comprehensive maturity model for digital transformation. The model comprises five critical dimensions: industry environment, strategy and organization, digital infrastructure, business process and management digitization, and digital performance. These dimensions encompass a total of 25 assessment indexes. To validate the model's feasibility and effectiveness, a digital transformation maturity assessment was conducted within China's construction industry.FindingsThe results of the maturity assessment within the Chinese construction industry reveal that it currently operates at the third level of digital maturity (defined level). The industry's maturity score stands at 2.329 out of 5. This outcome indicates that the developed model is accurate and reliable in assessing the level of digital transformation maturity within the construction industry.Originality/valueThis paper contributes both practical and theoretical insights to the field of digital transformation within the construction industry. By creating a tailored maturity model, it addresses a significant gap in existing research and offers a valuable tool for assessing and advancing digital maturity levels within this industry.
Gender quotas for corporate boards: do they lead to more women in senior executive management?
Authors: Halrynjo Sigtona , Teigen Mari 
Published: April 2024

Purpose
The European Union (EU) has recently adopted gender quotas for corporate boards (CBQ), anticipating ripple effects on women’s careers in the companies concerned, as well as throughout the economy. The purpose of this paper is to investigate whether CBQ has spurred ripple effects and discuss mechanisms hindering or facilitating women’s occupancy of top executive positions.

Design/methodology/approach
Norway was the first country in the world to introduce CBQ in 2003, with full effect from 2008. The policy requires company boards to be composed of 40% of each gender. Drawing on original data mapping boards and executive committees in Norway’s 200 largest companies, the authors analyze the association between CBQ and the gender composition of executive management almost 15 years after the full implementation. The data include both companies covered by the CBQ and large companies not covered.

Findings
The investigation does not find a positive association between CBQ and more women in executive positions. Thus, the ripple effect hypothesis of CBQ is not supported. CBQ may have contributed to an increased awareness of gender imbalances, yet these findings indicate that to achieve more gender balance in executive positions, scholars and practitioners may need to focus more on gendered conditions and processes in organizations and society throughout executive careers than on the gender composition of boards.

Originality/value
This paper provides empirical analyses of original data 15 years after the implementation of CBQ. The authors further contribute to scholarly debate by identifying and discussing possible mechanisms that explain how requiring more women on corporate boards may – or may not – have ripple effects on executive management.
Using machine learning methods to predict future churners: an analysis of repeat hotel customers
Authors: Dursun-Cengizci Aslıhan , Caber Meltem 
Published: April 2024

Purpose
This study aims to predict customer churn in resort hotels by calculating the churn probability of repeat customers for future stays in the same hotel brand.

Design/methodology/approach
Based on the recency, frequency, monetary (RFM) paradigm, random forest and logistic regression supervised machine learning algorithms were used to predict churn behavior. The model with superior performance was used to detect potential churners and generate a priority matrix.

Findings
The random forest algorithm showed a higher prediction performance with an 80% accuracy rate. The most important variables were RFM-based, followed by hotel sector-specific variables such as market, season, accompaniers and booker. Some managerial strategies were proposed to retain future churners, clustered as “hesitant,” “economy,” “alternative seeker,” and “opportunity chaser” customer groups.

Research limitations/implications
This study contributes to the theoretical understanding of customer behavior in the hospitality industry and provides valuable insight for hotel practitioners by demonstrating the methods that facilitate the identification of potential churners and their characteristics.

Originality/value
Most customer retention studies in hospitality either concentrate on the antecedents of retention or customers’ revisit intentions using traditional methods. Taking a unique place within the literature, this study conducts churn prediction analysis for repeat hotel customers by opening a new area for inquiry in hospitality studies.
Mental health and positive aging: a positive autoethnographic case study of Joyce Shaffer
Authors: Shaffer Joyce , Gonot-Schoupinsky Freda 
Published: April 2024

Purpose
The purpose of this paper is to meet Dr Joyce Shaffer, PhD, ABPP, Clinical Associate Professor at the University of Washington.

Design/methodology/approach
This case study is presented in two sections: a positive autoethnography written by Joyce Shaffer, followed by her answers to ten questions.

Findings
In this positive autoethnography, Shaffer shares her life story and reveals numerous mental health and positive aging recommendations and insights for us to reflect on.

Research limitations/implications
This is a personal narrative, albeit from someone who has been a clinical psychologist and active in the field of aging for many decades.

Practical implications
A pragmatic approach to aging is recommended. According to Shaffer, “those of us who can recognize the beat of the historical drummer can harvest the best of it and learn from the rest of it.”

Social implications
Positive aging has strong social implications. Shaffer considers that it is not only about maximizing our own physical, mental, emotional and social health but also about maximizing that of others, to make our world a better place for everyone.

Originality/value
Positive aging can be experienced despite adversity. As Shaffer says, “Adversity used for growth and healed by love is the answer.”
Engineering strategies and challenges of endolysin as an antibacterial agent against Gram‐negative bacteria
Authors: Zheng Tianyu , Zhang Can 
Published: April 2024

AbstractBacteriophage endolysin is a novel antibacterial agent that has attracted much attention in the prevention and control of drug‐resistant bacteria due to its unique mechanism of hydrolysing peptidoglycans. Although endolysin exhibits excellent bactericidal effects on Gram‐positive bacteria, the presence of the outer membrane of Gram‐negative bacteria makes it difficult to lyse them extracellularly, thus limiting their application field. To enhance the extracellular activity of endolysin and facilitate its crossing through the outer membrane of Gram‐negative bacteria, researchers have adopted physical, chemical, and molecular methods. This review summarizes the characterization of endolysin targeting Gram‐negative bacteria, strategies for endolysin modification, and the challenges and future of engineering endolysin against Gram‐negative bacteria in clinical applications, to promote the application of endolysin in the prevention and control of Gram‐negative bacteria.
Review article: Contemporary management of gastrointestinal, pancreatic and hepatic toxicities of immune checkpoint inhibitors
Authors: Townsend Matthew J. , Benque Isaac J. , Li Michael , Grover Shilpa 
Published: April 2024

SummaryBackgroundImmune checkpoint inhibitors (ICIs) are effective oncologic agents which frequently cause immune‐related adverse events (irAEs) which can impact multiple organ systems. Onco‐Gastroenterology is a novel and emerging subspecialty within gastroenterology focused on cancer treatment‐related complications. Gastroenterologists must be prepared to identify and manage diverse immune‐mediated toxicities including enterocolitis, hepatitis, pancreatitis and other ICI‐induced toxicities.AimTo provide a narrative review of the epidemiology, diagnostic evaluation and management of checkpoint inhibitor‐induced gastrointestinal and hepatic toxicities.MethodsWe searched Cochrane and PubMed databases for articles published through August 2023.ResultsGastrointestinal and hepatic irAEs include most commonly enterocolitis and hepatitis, but also pancreatitis, oesophagitis, gastritis, motility disorders (gastroparesis) and other rarer toxicities. Guidelines from the National Comprehensive Cancer Network, American Society of Clinical Oncology and European Society for Medical Oncology, in combination with emerging cohort and clinical trial data, offer strategies for management of ICI toxicities. Evaluation of irAEs severity by formal classification and clinical stability, and a thorough workup for alternative etiologies which may clinically mimic irAEs underlie initial management. Treatments include corticosteroids, biologics and other immunosuppressive agents plus supportive care; decisions on dosing, timing and choice of steroid adjuncts and potential for subsequent checkpoint inhibitor dosing are nuanced and toxicity‐specific.ConclusionsExpanding clinical trial and cohort data have clarified the epidemiology and clinical characteristics of gastrointestinal, pancreatic and hepatic toxicities of ICIs. Guidelines, though valuable, remain based principally on retrospective cohort data. Quality prospective, controlled studies may refine algorithms for treatment and potential immunotherapy rechallenge.
Tracing young people's engagements with the diplomacy and geopolitics of a British Overseas Territory
Authors: Benwell Matthew C. , Pennell Catriona , Pinkerton Alasdair 
Published: April 2024

AbstractResearch from political geographers has increasingly identified the diverse actors, practices, and performances of diplomacy, challenging narrow conceptions that had tended to associate them with the state alone. The following paper engages this plurality directly through, on the one hand, its focus on young people as diplomatic actors and, on the other, the diplomacy of a British Overseas Territory (OT)—the Falkland Islands—a polity characterised by its liminal subjectivity between colonial dependency and independent statehood. In 2022, to mark the 40th anniversary of the Falklands War, we partnered with the Falkland Islands Government Office (FIGO) in London, to design, deliver and evaluate a national schools' competition. The Falklands Forty Schools Competition (FFSC) culminated in an eight‐day trip to the Islands for seven prize winners. The paper reflects on our role in co‐organising the competition and the opportunities it afforded to observe young people probe and critically question the official narratives presented to them by government representatives. This offered us the opportunity to explore how geopolitical and diplomatic narratives can be projected, negotiated and challenged by young people in the context of a highly curated trip with narrative projection at its heart. We show how young people through their participation in the competition and, more specifically, a trip to the Falkland Islands, were able to identify slippages and inconsistencies in these ‘stable’ narratives related to governance of the Islands. The young people, far from being passive diplomatic ‘delegates’ unquestioningly imbibing the information presented to them were, instead, highly aware of narrative tipping‐points, tensions and slippages in their engagements with government representatives and diplomats.