bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nationwide survey on the transition of treatment protocols after the introduction of insurance coverage for assisted reproductive technology in Japan: The IZANAMI project
Authors: Kuroda Keiji , Jwa Seung Chik , Shirasawa Hiromitsu , Harada Miyuki , Osuga Yutaka , Yamada Mitsutoshi 
Published: February 2025

AbstractAimHow has the treatment policy changed since the introduction of health insurance coverage for assisted reproductive technology (ART) in Japan?MethodsThis study was conducted as a nationwide fact‐finding survey to determine the current situation of ART treatment in Japan, the IZANAMI project. Among the 616 ART facilities across Japan, 283 (45.9%) that responded to the first (December 2021–February 2022) and second surveys (December 2023–January 2024) were recruited. Information on the clinical practices was collected via a questionnaire survey and analyzed.ResultsAmong the facilities with ≤200, 201–500, 501–1000, 1001–2000, and ≥2000 annual oocyte retrieval (OR) cycles, 93.9%, 88.7%, 75.0%, 69.7% and 42.9% performed ≥80% of their OR cycles using health insurance, respectively (p < 0.001), whereas 51.9%, 53.7%, 41.0%, 40.0% and 12.5% exhibited an increase in number of OR cycles, respectively (p = 0.03). Therefore, a significantly higher proportion of smaller‐scale institutions than larger clinics had insured treatment and an increase in the number of OR cycles. Significantly more large clinics than small facilities selected mild stimulation, intracytoplasmic sperm injection, and freeze‐all embryo cycle; however, no significant transitions were observed in the main policies for ART, regardless of facility size. However, the indication for mild stimulation significantly increased in normal to high responders, and the choice of ovarian stimulation protocol according to the patient's wishes was significantly reduced.ConclusionsSmall‐scale institutions were more likely to offer insured treatment and increase the number of OR cycles than large facilities; however, the main protocols did not significantly change.
Clinical, biological, and neuroimaging profiles for motoric cognitive risk syndrome in older adults: The MIND‐China study
Authors: Han Xiaolei , Han Qi , Wang Xiaojie , Liu Rui , Zhao Mingqing , Wang Chaoqun , Wang Jiafeng , Song Lin , Han Xiaojuan , Dong Yi , Grande Giulia , Kivipelto Miia , Ngandu Tiia , Du Yifeng , Wang Yongxiang , Qiu Chengxuan 
Published: February 2025

AbstractBackgroundMotoric cognitive risk syndrome (MCR) has been associated with dementia, functional dependence, and mortality. We sought to describe the prevalence and distribution of MCR and to explore the clinical, biological, and neuroimaging profiles for MCR in rural‐dwelling Chinese older adults.MethodsThis population‐based study included 5021 dementia‐ and disability‐free participants (mean age 70.3 years) in MIND‐China. Of these, data were available in 1186 for blood biomarkers of Alzheimer's disease and vascular injury and in 1159 for structural brain magnetic resonance imaging biomarkers. MCR was defined as having both subjective memory complaints and gait speed ≥1 standard deviation below the age‐ and sex‐specific means. Data were analyzed using logistic regression models and voxel‐based morphometry methods.ResultsThe overall prevalence of MCR was 13.58%, which was higher in females than in males and increased with age. Controlling for demographic and lifestyle factors, obesity, diabetes, dyslipidemia, coronary heart disease, stroke, osteoarthritis, hip fracture, and depressive symptoms were significantly associated with an elevated likelihood of MCR (p < 0.05). MCR was significantly associated with smaller volumes of the total brain tissue, thalamus, hippocampus, cerebellum, insula, supplementary motor area, and inferior frontal gyrus, higher volumes of white matter hyperintensities, and an increased likelihood of lacunes (all p < 0.05), but not with any of the examined blood biomarkers (p > 0.05).ConclusionsMCR affects approximately one‐seventh of rural‐dwelling Chinese older adults. The clinical and neuroimaging profiles for MCR are characterized by cardiometabolic disorders, osteoarthritis, hip fracture, and depressive symptoms as well as global and regional brain atrophy and cerebral microvascular lesions.
Impact of higher temperatures on yolk sac absorption and early development in hybrid catfish between Clarias gariepinus and C. macrocephalus
Authors: Rey Juniman , Nguyen Ton Huu Duc , Singchat Worapong , Punthum Thitipong , Kraichak Ekaphan , Panochit Pichit , Maneeaphai Wiroon , Phuonnim Anake , Sengtrakool Sayam , Sriphairoj Kednapat , Hatachote Sittichai , Muangmai Narongrit , Chaiyes Aingorn , Duengkae Prateep , Matsuda Yoichi , Prasanpan Jiraboon , Srikulnath Kornsorn 
Published: February 2025

AbstractClimate change has driven global temperature increases, resulting in severe heat waves, altered precipitation patterns, and extreme weather events. In April 2024, a massive die‐off of hybrid catfish larvae and fry occurred in Thai aquaculture farms, coinciding with elevated temperatures of air (37–41°C) and freshwater (30–32°C). This study aimed to investigate the correlation between elevated temperatures and abnormal embryonic development in hybrid catfish. Controlled mating of male North African catfish (Clarias gariepinus) and female bighead catfish (Clarias macrocephalus) was conducted in May and June 2024. We examined the effects of water temperature changes in hybrid catfish, focusing on fertilization, hatching, yolk sac absorption, and mouth morphology, while keeping the conditions of water quality, feeding, and disease management constant. The fertilization rate was 67.7% at 29°C, whereas it significantly decreased to 59.0% at 32°C. The hatching rate decreased from 43.4% at 29°C to 26.6% at 32°C. Survival rates plummeted, with no larvae surviving beyond 72 h post‐hatching (hph) at 32°C. Yolk sac absorption was notably accelerated at 32°C, being completely absorbed by 48 hph. Mouth morphometry revealed that a gap in the mouth started to develop 12 hph, and the opening size of the mouth increased out to 72 h. These findings indicate that higher temperatures (32°C) lead to faster yolk absorption, causing embryos to deplete yolk reserves rapidly, potentially before full development and independent feeding. This results in a smaller body size and lower survival rates. Present study provides crucial insights for enhancing breeding practices and creating management protocols for hybrid catfish hatcheries during the period season of high temperature in the context of climate change.
Opportunistic Screening for Local Osteoporosis of the Proximal Humerus on the Basis of Hounsfield Units: A Study of Patients With Rotator Cuff Tears
Authors: Liu Guihu , Wang Xiaolong , Wang Xieyu , Zhang Yaxuan , Ma Yinguang , Zhou Haibin , Shen Guangsi 
Published: February 2025

ABSTRACTObjectivesThe accuracy of dual‐energy x‐ray absorptiometry (DXA) in predicting proximal humerus osteoporosis in patients with rotator cuff tears (RCTs) undergoing arthroscopic rotator cuff repair (ARCR) is uncertain. The aim of this study was to assess the correlation of computed tomography (CT) Hounsfield units (HU) and the deltoid tuberosity index (DTI) with bone mineral density (BMD), and to evaluate the predictive value of HU values for implant selection.MethodsThis study analyzed the preoperative shoulder CT scans and x‐rays of 184 patients who underwent ARCR. Preoperative CT scans were utilized to assess the multiple anatomical parts of the proximal humerus to ascertain the HU values, whereas preoperative x‐rays were analyzed to derive the DTI. Among them, 104 patients with preoperative DXA data were grouped according to the WHO diagnostic criteria for osteoporosis to establish the threshold HU values. The correlation between HU values and DTI and the lowest T score on DXA was studied, and the relationship between the HU value and the type of implant selected was discussed. The Pearson correlation coefficient was employed to examine the relationship between HU values, DTI, and T scores. And the Spearman correlation coefficient was employed to examine the relationship between HU values and enhanced fixation.ResultsThere was a significant correlation between the HU values and DTI and the lowest T score (rHU&T score = 0.539–0.576, rDTI&T score = 0.288, p < 0.05). On the basis of the lowest T score grouping, the threshold HU values for diagnosing proximal humeral osteoporosis were obtained: proximal humerus = 47.44, humeral head = 97.62, greater tuberosity = 10.9, and lesser tuberosity = 5.38. There was no correlation between HU values and enhanced fixation (using 5.5‐mm anchors or metal anchors instead of 4.5‐mm anchors or all‐suture anchors) (r = −0.143 to −0.027, p > 0.05).ConclusionProximal humeral HU values were significantly correlated with DTI and the lowest T score on DXA. When the HU values in the proximal humerus in patients with RCTs fall below the thresholds, the surgery should be carefully planned. No correlation exists between HU values and enhanced fixation, thus further investigation through group studies is warranted.Level of EvidenceLevel III, study of nonconsecutive patients, diagnostic study.
Historical Development and Experience of Day Surgery in China: From the Perspective of Anesthesiologists
Authors: Luo Jiangrong , Xie Chunbao , Fan Dan 
Published: February 2025

ABSTRACTBackgroundDay surgery has become the main mode of surgery in American and European countries, but it is still in the early stage in developing countries due to the limitation of medical technology and the backward management concept. At present, day surgery accounts for more than 60% of elective surgery in many countries in Europe and North America and more than 85% in countries such as the United Kingdom and the United States. There are 8469 ambulatory surgery centers in the United States in 2023. In China, the first ambulatory surgery center was established in 2001. In 2018, more than half of the tertiary hospitals (high‐level hospitals) in China carried out day surgery, of which 639 hospitals set up ambulatory surgery centers; the proportion of day surgery in elective surgery increased to 12.8%. The annual number of day surgeries exceeded 1.25 million. In 2022, our hospital established an ambulatory surgery center managed by anesthesiologists. Day surgery requires anesthesiologists to participate in the whole process of patient management from preoperative preparation to postoperative recovery. The establishment of ambulatory surgery centers managed by anesthesiologists is of great significance to China, developing countries, and the whole world.ObjectivesSo this study aimed to review the development of day surgery in China, combine Chinese government policy evolution, summarize the management model of Chinese ambulatory surgery centers, guide the establishment of ambulatory surgery centers in low‐ and middle‐income countries, and highlight and analyze the advantages of anesthesiologist‐managed ambulatory surgery centers as distinct from other physician‐managed ones.DiscussionWe call on anesthesiologists, other physicians, surgeons, nurses, and health system managers around the world to promote efficient, low‐cost day surgery in developing countries and thereby increase access to surgical treatment for the world's poor.
Divergent MYB paralogs determine spatial distribution of linalool mediated by JA and DNA demethylation participating in aroma formation and cold tolerance of tea plants
Authors: Yue Rui , Li Yaling , Qi Yujia , Liang Xiaoyu , Zheng Ziqing , Ye Zhili , Tong Wei , Si Xiongyuan , Zhang Yanrui , Xia Enhua , Li Penghui 
Published: February 2025

SummaryLinalool not only is one of characteristic flavour volatiles of tea, contributing to floral aroma, but also a kind of defensive compounds, playing essential roles in resistance against biotic/abiotic stresses. Although the linalool synthases have been identified, much is unknown about the regulation mechanism in tea plants. We identified two pairs of MYB paralogs as linalool biosynthesis activators, in which one pair (CsMYB148/CsMYB193) specifically expressed in flowers, and another (CsMYB68/CsMYB147) highly expressed in flowers, leaves, fruits and roots. These activators interacted with CsMYC2 to form MYC2‐MYB complexes to regulate linalool synthase. While Jasmonate ZIM‐domain (JAZ) proteins served as the linalool biosynthesis repressors by interfering MYC2‐MYB complex. Further, we found that the transcripts of CsMYB68/CsMYB147 were significantly upregulated by jasmonic acid (JA) to improve linalool products during tea processing and that linalool pathway may as one of the downstream pathways of JA signalling and DNA methylation processes to participate in cold resistance. Under cold stress, JA signalling was activated to elevate the abundance of MYC‐MYB complexes; meanwhile, DNA demethylation was also activated, leading to declining methylation levels and increasing transcripts of CsMYB68/CsMYB147. Our study provides a new insight into synergistically improving tea quality and tea plant resistance.
Towards a latent space cartography of subjective experience in mental health
Authors: Manuel Shawn , Gagnon Jean , Gosselin Frédéric , Taschereau‐Dumouchel Vincent 
Published: February 2025

AimsThe way that individuals subjectively experience the world greatly influences their own mental well‐being. However, it remains a considerable challenge to precisely characterize the breadth and depth of such experiences. One persistent problem is the lack of objective tools for directly quantifying and comparing narrative reports of subjective experiences. Here, we develop a new approach to map and compare reports of experience using the latent space of artificial neural networks.MethodsUsing a series of 31 prompts, including 30 images and one open‐ended question, we quantified how the verbal reports provided by participants (n = 210, 50% female) deviate from one another and how these variations are linked to subjective experience and mental health.ResultsWe found that latent space embeddings of experience can accurately predict subjective judgments of valence and arousal in a series of emotional pictures. Furthermore, we show that narrative reports to ambiguous images can accurately predict transdiagnostic factors of mental health. While distortions in the latent space of artificial neural networks are notoriously difficult to interpret, we propose a new approach to synthesize visual stimuli with generative artificial intelligence that can be used to explore semantic distortions in reported experiences.ConclusionsIn sum, latent space cartography could offer a promising avenue for objectively quantifying distortions of subjective experience in mental health and could ultimately help identify new therapeutic targets for clinical interventions.
PLACK Syndrome in Two Unrelated Indian Children Caused by Novel Pathogenic Variants in the CAST Gene
Authors: Srinivas Sahana M. , Basavapura Shashikumar 
Published: February 2025

ABSTRACTPLACK syndrome is an autosomal recessively inherited genodermatosis characterized by peeling skin, leukonychia, acral keratoses, cheilitis, and knuckle pads caused by variants in CAST gene. This report describe two unrelated Indian children with typical features of PLACK syndrome and homozygous novel variants in the CAST gene.
Comparing Manual and Automatic Artifact Detection in Sleep EEG Recordings
Authors: Ujma Péter P. , Dresler Martin , Bódizs Róbert 
Published: February 2025

ABSTRACTSleep electroencephalogram (EEG) recordings can be contaminated by artifacts. Visual and automatic methods have been developed to mark such erroneous segments of EEG data. Here, we systematically explored the effect of artifacts on the sleep EEG power spectrum density (PSD), and we compared gold‐standard visual detections to a simple automatic detector using Hjorth parameters to identify artifacts. We found that most distortions in the all‐night average PSD occur because of a small minority of highly anomalous artifacts, which mainly affect the beta and gamma frequency ranges and NREM delta. Visual and automatic detections only showed moderate agreement in which data segments are artifactual. However, the resulting all‐night average PSD is highly similar across all methods, and PSDs calculated with all methods successfully recover the known correlations of PSD with age and sex. No parameter settings of the automatic detector clearly outperformed others. Additionally, we showed that accurate average PSD estimates can be recovered from just a fraction of available data epochs. Our results suggest that artifacts represent a minor and easily solvable problem in sleep EEG recordings. Most visually identified artifacts do not seriously distort estimates of mid‐frequency activity in the sleep EEG spectrum, and distortions to low and high frequencies can be eliminated using a simple automatic detection method nearly as well as with visual detections. These findings show that the visual inspection of EEG data is not necessary to eliminate the effects of artifacts, which is encouraging for the expected performance of automatic preprocessing in large sleep EEG databases.
Who views what from whom? Social media exposure and the Chinese public's risk perceptions of climate change
Authors: Huang Jiayu , Bu Yumei 
Published: February 2025

AbstractThe Chinese public is increasingly experiencing the local impacts of climate change, whereas the government downplays its domestic effects and critical opinions on environmental governance. As climate change perceptions are crucial for individual risk management, adaptation, and collective climate actions, it is vital to explore how these perceptions are shaped. Given the increasing significance of social media in climate change discourse, this study employs survey data from the 2021 Environmental Risk Perceptions and Environmental Behaviors of Urban Residents Project to investigate how social media exposure influences risk perceptions of climate change among the Chinese public. Drawing on the social amplification of risk framework, this study examines the effect of exposure to environmental information, exposure to opinion diversity, individuals’ social media network ties to environmental opinion leaders, and the interaction between social media exposure and cultural values. The results indicate that in the contexts where climate change is neither politically divisive nor openly debated, social media exposure to diverse opinions and social media network ties to environmental scholars positively predict risk perceptions. Additionally, egalitarianism and fatalism are found to moderate the effect of these connections with environmental scholars. This study extends previous research, which focuses largely on the association between the frequency of social media exposure and risk perceptions of climate change, by revealing a more comprehensive and nuanced process that links social media exposure to climate change perceptions.
The taxonomy of risky activities and technologies: Revisiting the 1978 psychological dimensions of perceptions of technological risks
Authors: Sokolowska Joanna , Rey Zofia 
Published: February 2025

AbstractThe objective of this study is to replicate the original study by Fischhoff et al. (1978) and its replication by Fox‐Glassman and Weber (2016) and to examine whether risk perceptions for the previously studied activities and technologies have changed over the past 40 years, especially when activities/technologies related to contemporary concerns are included. To achieve this goal, the list of activities/technologies has been modified. To facilitate the analysis of individual data, all participants were asked to rate the benefits and risks of 24 activities. The within‐participant approach was also used to achieve the second objective of our study: to analyze the relationship between perceived benefits and risks. In summary, the design of this study differed from previous studies in the following ways: (1) Nine activities/technologies were added related to contemporary concerns such as global warming and fake news on the Internet; (2) all participants rated both benefits and risks; (3) data were collected online (as in the 2016 study); (4) the study was conducted by Prolific with a sample size large enough to detect medium‐size effects (n = 382). The two‐factor structure proposed by Fischhoff et al.—unknown risk and dread risk—was confirmed on aggregated data for the new set of hazards, which included novel hazards. At the level of individual data, modest support for this structure was observed, and a very strong inverse relationship between perceived benefits and risks was observed.
Sexual and Gender Minority Stress in Nonsuicidal Self‐Injury Engagement: A Meta‐Analytic Review
Authors: Ahrenholtz Michaela S. , Nicholas Julia , Sacco Abbi , Bresin Konrad 
Published: February 2025

ABSTRACTIntroductionSexual and gender minority (SGM) individuals report a higher prevalence rate of nonsuicidal self‐injury (NSSI) compared to their cisgender heterosexual peers. Minority stress theory posits that the unique stressors experienced by those with a minoritized sexual orientation and/or gender identity increase the risk of negative health outcomes. As such, SGM stress may be a significant risk factor for NSSI and may help explain the disparate prevalence rates in the community.MethodThus, a meta‐analysis was conducted to assess the relationship between SGM stress and NSSI (k = 42; N = 253,686).ResultsBroadly, SGM stress was significantly positively related to NSSI engagement (r = 0.15). While this effect size is small in absolute size, it is comparable to other evidence‐based risk factors for NSSI, such as impulsivity. Contrary to our hypothesis, the number of items used to assess NSSI engagement did not significantly moderate the relationship (b = −0.001). Exploratory analyses found no significant difference between proximal and distal SGM stressors (b = 0.07), sexual minority stress and gender minority stress (b = 0.03), nor assessment of lifetime compared to past year NSSI engagement (b = 0.08).ConclusionOverall, the results of this meta‐analysis support that SGM stress is a significant risk factor for NSSI and should be integrated into interventions for NSSI.