bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploratory laparotomy and splenectomy in the diagnosis of Hodgkin's disease in children
Authors: Kolygin B. A. , Fedoreev G. A. 
Published: February 2007

AbstractThirty‐three children with histologically proved Hodgkin's disease underwent exploratory laparotomy with splenectomy and biopsy of lumbar lymph nodes, liver, and bone marrow. In 13 patients (39%) the lesion of spleen and/or splenic hilar lymph nodes was diagnosed. The involvement of spleen was mostly found in patients with mixed cellularity type, in the presence of systemic symptoms (“B”), and in the biological stage “b.” Involvement of the liver was found in 1 patient, of the hepatic hilar lymph nodes in 3 patients, and of the bone marrow in 4 patients. The lymphographic and histologic data as regards lumbar lymph nodes coincided in 65% of cases. After operation the stage of the disease was changed in 48% patients. The early and late complications were not numerous.
Adenocarcinoma‐associated antigen: Enhancement of tumor growth with serum from animals bearing adenocarcinoma
Authors: Hakim Anwar A. 
Published: February 2007

AbstractWhy do tumors continue to grow in the presence of cell‐mediated immune reactions? When inoculated subcutaneously, 105 viable spontaneous mammary adenocarcinoma cells produced solid tumors that progressively proliferated and eventually kilted all the recipient mice. During the first 10 days after inoculation, the mice developed antibody titers, and the serum acquired toxic activity against the tumor cells. As the tumor gained in size these two activities ceased. Serum of normal mice had no effect on the tumor; the serum of mice immunized with an adenocarcinoma‐associated antigen (a glycoprotein) inhibited growth, but that of mice with progressive tumors enhanced proliferation of the tumors.
Patterns of serial CEA assays and their clinical use in management of colorectal cancer
Authors: Sugarbaker Paul H. , Skarin Arthur T. , Zamcheck Norman 
Published: February 2007

AbstractThrough persistent clinical research efforts, the CEA test has developed into a useful although complex disease monitor for colorectal cancer. Although improved or prolonged survival from its use has not been demonstrated, CEA monitoring may allow more knowledgeable patient management. Several reports indicate that postoperative serial CEA assays may identify patients with early recurrence, especially when assays are done frequently. Patients with elevated pretreatment CEA levels usually showed progressively rising titers before other objective evidence of recurrence was apparent. A progressively rising CEA titer correlated well with recurrent cancer, but a normal CEA could not be used as proof of its absence. Persistently elevated CEA titers post‐treatment were caused either by persistent disease or by nontumor‐related factors. The CEA assay was not a substitute for clinical follow‐up but was an adjunct in the diagnosis of early recurrence.Patients with elevated CEA levels caused by localized disease treated by radiation therapy demonstrated a marked fall in serial CEA levels if all CEA‐producing tumor was localized within the radiation portal. The use of pretreatment CEA values plus the pattern of CEA response to irradiation may help in the selection of fulguration versus abdominoperineal resection as primary treatment for rectal cancer. Persistently low serial CEA titers after irradiation therapy correlated with disease control.The use of frequent serial CEA assays in patients treated with chemotherapy compared well with other parameters as a monitor of disease progression or regression. When used with other clinical parameters, serial CEA trends appeared to be a useful adjunct in assessing the effectiveness of chemotherapy. A fall in circulating CEA or the stabilization of a rising titer after starting chemotherapy usually indicated an effective regimen, whereas a rising CEA titer may signal the need to initiate or to change chemotherapy.
Some factors involved in the skin flap delay phenomenon
Authors: O'neill John V. , Toomey James M. , Snyder G. Gordon 
Published: February 2007

AbstractThe use of skin flaps for reconstruction following extensive ablative surgery in the head and neck area has played a major role in the improvement of the results being attained. Using the pig as an experimental animal various factors of flap orientation, skin incisions and flap undermining were investigated.Results confirmed the ineffectiveness of incision alone as a delay maneurver and suggested that anatomical orientation of cutaneous skin flaps was not of crucial significance. The complete mechanism of the positive effects of delay remains undefined.
Recent progress in chemotherapy and immunotherapy of sarcomas of bony origin, both as primary and adjunctive therapy
Authors: Copeland Murray M. 
Published: February 2007

AbstractTreatment for primary malignant tumors of bone, in the past several decades, has yielded uniformly poor results. Recent progress in chemotherapy and immunotherapy are detailed. An important advance in treating osteogenic sarcoma has been the application of adjuvant chemotherapy after initial amputation. CONPADRI‐I and COMPADRI‐II chemotherapy (a multiple drug approach) is discussed. Adriamycin in combination or alone has proved effective in treating osteogenic sarcoma. Ewing's tumor is showing increased survival rates from radiation therapy alone, as well as by use of systemic adjuvant chemotherapy combined with local radiation. Adjuvant triple chemotherapy with radiotherapy has resulted in pronounced improvement in survival. Chondrosarcomas are largely chemotherapy‐resistant. Immunotherapy in bone tumors still is in the experimental stage and investigations with immunotherapy are preliminary. It appears, however, that the immunological status of a patient definitely relates to prognosis. Through increased sophistication in specific chemotherapy and magnitude of treatment, further advances in treatment of primary malignant bone tumors may be expected.
The influence of nonspecific immunotherapy on the course of Murine Melanoma
Authors: Woods John E. , Ritts R. E. 
Published: February 2007

AbstractBCG, Corynebacterium parvum, vitamin A, and levamisole were continuously administered to C57 BL/6 mice bearing B16 melanoma prior to, with, and following tumor implantation as well as before and coincident with surgical excision of the implanted tumor. Only the group given levamisole prophylactically for 8 weeks before tumor inplantation showed a significant difference from control mice but a tenfold increase in dosage in this drug did not exert a comparable effect.
Malignant teratoma of the nasal cavity
Authors: Petrovich Zbigniew , Wollman Jerome , Acquarelli Mario , Barton Richard 
Published: February 2007

AbstractA case of malignant teratoma of the nasal cavity in an adult is presented. Histologically, the tumor consisted of mesenchymal malignant structures in addition to entodermal and ectodermal malignant elements. Whereas surgical treatment of the primary tumor has been generally considered preferred, this patient was given a full course of radiation therapy alone to the primary lesion. There is no clinical evidence of tumor 5 years following diagnosis.Three years following treatment of the primary tumor, neck lymph node metastasis appeared contralaterally. Management of this problem was with radical neck dissection followed by postoperative radiotherapy. Function of the eyes, nose, and paranasal sinuses remains normal. A review of the literature suggests that radiotherapy is of little value in the management of malignant teratomas. This case demonstrates an opposite point of view.
Responsiveness to endocrine manipulations in breast cancer after “prophylactic” castration
Authors: Kaufman Richard , Salem Philip , Wittes Robert E. 
Published: February 2007

AbstractTwo hundred and one cases of premenopausal women with breast cancer who underwent prophylactic castration with subsequent recurrence were reviewed to ascertain the degree of responsiveness of these patients to subsequent endocrine manipulation. We show that the standard endocrine manipulations, particularly the major ablations, retain a fair degree of activity in this group. There is a suggestion that the longer the castration‐recurrence interval, the higher the chance of a response, but the difference is significant only for osseous‐dominant disease. As in other patient groups, responders to subsequent endocrine manipulations live longer than nonresponders.
Paget's disease of the breast
Authors: Freund H. , Maydovnik M. , Laufer N. , Durst A. L. 
Published: February 2007

AbstractTwenty‐nine histologically verified cases of Paget's disease of the breast treated at the Hadassah University Hospital in the years 1949–1972 were followed up and analyzed. Dividing this material into two groups according to the presence or absence of a palpable breast tumor revealed significant difference in behavior and survival. Patients with a breast mass (34%) had a 50% axillary lymph node involvement and behaved as with any other ordinary breast cancer, with a 5‐year survival rate of 40% and a 10‐year survival rate of 33%. Patients with no palpable breast mass (66%) had only a 10.5% lymph node involvement, the 5‐year survival rate being 94% and the 10‐year survival rate being 91%. Delay in diagnosis seems to play no significant factor in survival rates and outcome. We believe radical mastectomy to be the treatment of choice in all cases of Paget's disease of the breast.
Increased effect of a transmissible entity on the control of cancer in C3 H/St mice
Authors: Strong Leonell C. , Matsunaga Henry 
Published: February 2007

AbstractThree hundred and seventy‐one mice of the C3H/St inbreds bearing spontaneous tumors of mammary gland origin have been used in this experiment. All mice studied were lineal descendents of a tumorbearing mouse which had been injected with a liver extract. In this descent there appears to be a transmissible entity presumably induced by the injection of the liver extract.Following 15 generations of inbreeding after the appearance of a transmissible entity, a second sudden reversal of effect on cancer growth in mice has been indicated.This change has progressively altered the growth of cancer from a very low effect to a maximal effect, i.e., to a complete regression of a high percentage of the tumor.The maximal effect of the transmissible entity is the complete suppression of the growth of cancer during, at least, through the 25th period of observation, thus producing negative values of tumor growth.All these effects of the growth and fate of spontaneous tumors of mammary gland origin in mice have been obtained in a single lineal descent of C3H/St inbreds without resorting to any outcross.
Failure of mice infected with Rauscher leukemia virus (RLV‐A) to develop splenic colonies
Authors: Bergson Alan , Lobue Joseph , Fredrickson Torgny N. , Gordon Albert S. 
Published: February 2007

AbstractA progressive increase occurs in the CFU‐S/106 spleen cells with the development of RLV‐A‐induced erythroleukemia. In addition, alteration of the spleen by the RLV‐A appears to prevent the seeding and development of spleen colonies in infected mice.
The treatment of gastric cancer with combined surgical resection and chemotherapy
Authors: Franz Jerry L. , Cruz A. B. 
Published: February 2007

AbstractA series of 156 patients with gastric cancer during a 15‐year period were reviewed retrospectively to determine the effectiveness of combined surgery and adjuvant chemotherapy. The patients were divided into a 9‐year prechemotherapy period and a 6‐year chemotherapy period. Review of the data revealed an increase in the incidence of distant disease. The utilization of surgery as the only mode of treatment declined. Combination surgery and adjuvant chemotherapy utilization increased. Comparison of survival for surgery vs. adjuvant chemotherapy, expressed as percentage of survivors for each year, revealed an increase at 1 and 2 years with no difference at 3 years for all stages. A similar comparison for patients with regional spread showed an increase at 1,2, and 3 years with no difference thereafter. The 5‐year survival was 5% for both groups. The data has suggested that surgery and adjuvant chemotherapy increases 1‐, 2‐, and 3‐year survival rates but does not affect the longterm results.
Oral cancer in puerto rico
Authors: Fischman Stuart L. , Martinez Isidro 
Published: February 2007

AbstractAll cancer cases diagnosed in Puerto Rico are analyzed and registered in the Central Cancer Registry. The incidence of oral cancer in Puerto Rico is fourth‐highest in the world. (In 1972 oral cancer accounted for 72% of all cancers in males in Puerto Rico.) A review of the data revealed important contrasts with reported statistics from the continental United States (e.g., 75.6% of the cases in Puerto Rico were initially treated by radiation, compared with 15.3% of the cases in Western New York State).
Lymphocyte blastogenic responses to allogeneic leukocytes and autochthonous tumor cells in colorectal carcinoma
Authors: Jubert Andrév. , Talbott Timothy M. , Mazier W. Patrick , Mackeigan John M. , Campos Manuel M. , Muldoon James P. , Benjamin Howard E. , Ferguson James A. , Bowman Harold E. 
Published: February 2007

AbstractThe blastogenic reactivity of peripheral blood lymphocytes (PBL) and mesenteric lymph node lymphocytes (LNL) against normal allogeneic leukocytes and autochthonous colorectal carcinoma cells is evaluated in 36 patients, and correlated with the patients' Dukes classification. Mesenteric LNL react significantly better than PBL to allogeneic leukocytes in both Dukes B and C (p < 0.05). There are too few patients in Dukes A and D to permit statistical evaluation, but the trend is the same. By contrast, LNL fail to react to autochthonous tumor cells in all classes, except in a few Dukes B patients. The proportion of PBL reactivity to autochthonous tumor cells seems to increase for Dukes C and D. It is possible that specific lymphocyte reactivity in colorectal carcinoma may be related to the antigenicity and immunogenicity of the tumor.
Survival of patients with carcinoma of breast without lymph node metastases in relation to the tumor types
Authors: Malinin Theodore I. , Lumb George D. 
Published: February 2007

AbstractCarcinoma of breast radical mastectomy specimens were examined. The tumors were classified in accordance with their morphologic appearance. The tumors were also graded on the basis of their cytological makeup and assigned a cytologic malignancy score (CMS). While the classification of tumors was based on the overall pattern of the tumor, the CMS was arrived at by examining the least differentiated portion of the tumor. The following conclusions were suggested by the study: Patients with tumors with high CMS have a poor prognosis, even in the absence of axillary lymph node metastases. It appears reasonable to suggest that patients without overt metastases, but with high CMS, should be considered for treatment with all therapeutic measures available. Such an aggressive approach to patients with low CMS does not appear to be justified.
Lymphoblastogenesis inhibitory factor produced by human lung cancer cell lines
Authors: Han Tin , Minowada Jun 
Published: February 2007

AbstractA comparative study of the inhibitory effect of cell‐free supernatants (CFS) from human lung cancer cell lines (ChaGo and PC‐1) and from a human embryo fibroblast cell line on lymphocyte blastogenesis indicates that both lung cancer cell lines produce a large amount of the inhibitory factor while the production of such a factor from a control noncancer cell line is essentially very minimal or absent. The inhibitory effect of CFS of the lung cancer cell lines is not due to direct cytotoxicity. The inhibitory effect is found to be partially sensitive to heat treatment. A significant inhibition is still seen, even when the CFS of the lung cancer cell lines were present for 1 hour prior to the addition of phytohemagglutinin (PHA).
Inhibitory effects of xenogeneic antiserum on the growth of Moloney virus‐induced sarcomas
Authors: Pierce George E. 
Published: February 2007

AbstractAn antiserum was developed in rabbits by injections of a virus concentrate from Moloney murine sarcomas. Passive transfer of this antiserum attenuated the growth of both primary and transplanted Moloney murine sarcomas. It also facilitated tumor regression and increased survival times of young mice with primary Moloney sarcomas.
Current status of the therapy of advanced renal carcinoma
Authors: Hrushesky William J. , Murphy Gerald P. 
Published: February 2007

AbstractA preclinical murine renal tumor model system is available for evaluation of the effectiveness of therapeutic agents. Clinical review reveals that objective response rates to hormonal agents reported since 1971 have been substantially lower than those reported prior to 1971. Many chemotherapeutic agents have not been adequately evaluated clinically or with the experimental model. Vinblastine to date may be the most active single agent with a 25% objective response rate. At the present time, it is uncertain whether combination chemotherapy or hormonal chemotherapy add to response rates obtained with single agents. There is some evidence that immunotherapy may be of some adjuvant benefit and, thus, may provide an additional avenue of investigation.
Metastatic choriocarcinoma of the nasal mucosa
Authors: Salimi Rahmatullah 
Published: February 2007

AbstractA patient with a chief complaint of epestaxis coughed persistently during her visit to the emergency room. Questioning revealed she also had vaginal bleeding and occasional bloody sputum. Gynecological examination, a Pap smear, and pathological evaluation showed choriocarcinoma. A chest X ray disclosed metastatic pulmonary choriocarcinoma. An ENT examination was carried out and showed a suspected area in the nasal mucosa which was bleeding. A Pap smear and biopsy taken from the suspected area also revealed choriocarcinoma.
The effect of surgical removal of a rat sarcoma on lymphocyte cytotoxicity
Authors: Rogers Galen W. , Miller Elizabeth E. , Rosato Francis E. , Rosato Ernest F. 
Published: February 2007

AbstractThe effect of surgical removal of tumors on cytotoxicity reactions was studied in Lewis‐Wister inbred rats bearing a transplantable methylcholanthrene‐induced sarcoma (MCI). Lymphocyte cytotoxicity and the effect of the serum in blocking (decreasing) or potentiating (increasing) lymphocyte cytotoxicity were studied using MCI tissue culture cells, prelabeled with 3H‐proline, as target cells. After surgical removal of the tumors, tumor nodules were again palpable in all rats by the seventh day after surgery and regrew at an accelerated rate. In control rats bearing the MCI sarcoma, serum blocking activity appeared between the 8th and 13th days and completely inhibited lymphocyte cytotoxicity until death of the animals. Surgical removal of the tumors resulted in a decrease in lymphocyte cytotoxicity and complete absence of serum blocking activity for at least 7 days. By the 13th day, when tumors were again growing rapidly, lymphocyte cytotoxicity had increased markedly, and blocking activity again appeared in the serum.
Adjuvant role of radiation in soft tissue sarcoma in adults
Authors: Hintz Brace L. , Charyulu Komanduri K. N. , Miller Wallace E. , Sudarsanam Anam 
Published: February 2007

AbstractForty‐seven patients with soft tissue sarcomas were analyzed retrospectively. Treatment was nonrandomized between surgery alone, preoperative radiation of 5,000 rads/5 weeks, postoperative radiation of 6,000 rads/6 weeks following total gross tumor removal, and postoperative radiation (variable doses) for residual gross or unresectable tumor. Preoperative radiation was not statistically better for local control or survival compared to postoperative radiation after local excision of gross tumor. Wide excision, higher postoperative radiation dosage, and/or enlarged radiation portals perhaps would improve results. Additional adjuvant therapies, such as chemotherapy or immunotherapy, need to be investigated.
Chemoimmunotherapy of a murine fibrosarcoma: Critical factors for success of combined modality therapy
Authors: Lundy Joel , Lovett Edmund J. , Hinchliffe Darlene , Schor Mark 
Published: February 2007

AbstractThiabendazole (TBZ), a new nonspecific immunopotentiator, was evaluated in combination with Cytoxan in the therapy of a syngeneic murine fibrosarcoma. The reduction of tumor burden by chemotherapy was critical in achieving an optimal response from immunotherapy. Eighty‐eight percent of the mice that responded to Cytoxan had sustained regression of tumor with TBZ treatment. The response to TBZ was markedly diminished, both in duration and magnitude, in the mice considered to be Cytoxan nonresponders.Timing of immunotherapy was also important. If Cytoxan and TBZ were given simultaneously, growth kinetics similar to those observed with Cytoxan alone were observed. However, if TBZ was given 4 days after Cytoxan administration, prolonged regression of tumor was seen.Alone, TBZ was most effective at a dose of 20 mg/kg. However, in combination with Cytoxan the most effective dose was 0.2 mg/kg. The implications of this finding are discussed.
Histopathological study of regional lymph nodes in osteosarcoma
Authors: Shrikhande S. S. , Rao R. S. 
Published: February 2007

AbstractThis paper presents the histological appearance of the lymph nodes in cases of osteogenic sarcoma of the limb bones. The nodes were studied for the degree of sinus histiocytosis. Cases with no sinus histiocytosis showed a poor prognosis while cases with moderate to marked sinus histiocytosis showed a better rate of survival. Since the regional lymph nodes play an important part in the immunological process, preservation of regional nodes is suggested.
X‐ray exposure and premature aging
Authors: Bertell Rosalie 
Published: February 2007

AbstractAn hypothesis of an aging effect of exposure to ionizing radiation in humans is proposed and given precise mathematical expression. The assumption is made that the biological changes which occur when humans are exposed to ionizing radiation from medical x ray are comparable to those occuring through the natural aging process, since both factors are known to increase the relative risk of nonlymphatic leukemia. This assumption focuses on this one aspect of aging only. The hypothesis that aging and exposure to ionizing radiation are comparable for increasing the relative risk of nonlymphatic leukemia is tested against the data from the Tri‐State Leukemia Survey. It is shown to explain the data in a statistically acceptable way, giving an estimate of 1 rad skin dose exposure to the trunk as comparable to 1 year natural aging. This research raises further questions concerning the effects of exposure to ionizing radiation, and presents a new methodology by which these questions may be researched.
Endodermal sinus tumor of the ovary and alpha fetoprotein: A case report
Authors: Thomas James H. , Panoussopoulos Dimitrios G. , Jewell William R. 
Published: February 2007

AbstractYolk sac tumors of the ovary are associated with elevations in serum levels of alpha fetoprotein (AFP). Thus, an antigenic marker is provided for evaluating therapeutic results in selected patients. A patient with a pure endodermal sinus tumor of the ovary is presented who underwent serial determinations of AFP. The effectiveness and limitations of serial AFP levels as demonstrated by this case are discussed in addition to the surgical and chemotherapeutic management of patients with yolk sac tumor of the ovary.