bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of Mir-21-5p Affects the Expression of LNCRNA X-Inactive Specific Transcript and Induces Apoptosis in MCF-7 Breast Cancer Cells
Authors: Nejaddehghan Samaneh , Zargar Seyed Jalal , Oloomi Mana , Baesi Kazem , Kouhsar Morteza 
Published: March 2024

Background: We aimed to investigate miR-21-5p inhibition effect on lncRNA-XIST expression and apoptosis status of MCF-7 cells.
Methods: The MCF-7 cells were cultured and transfected by the anti-miR-21-5p oligonucleotide and expression of miR-21-5p, lncRNA-XIST, apoptosis-associated genes (bax and p53) and one miR-21-5p-unrelated lncRNA (BC200) was assessed by RT-qPCR. Furthermore, cell viability checked by MTT assay and apoptosis and cell cycle in transfected cells were detected by flow cytometry. Also, bioinformatics analysis on the transcriptome data confirmed that the lncRNA XIST might have a critical role in breast cancer (BC) cell apoptosis through ceRNAs mechanism and possible regulatory interactions with miR-21-5p.
Results: Expression of miR-21-5p and lncRNA-XIST was significantly down- and up-regulated respectively (P<0.05). However, there was no significant change in lncRNA-BC200 expression. Also, the expression of bax and p53 upraised significantly (P<0.05). In transfected cells, MTT and flow cytometry assays reported a highly significant decrease and increase in viability and apoptosis respectively.
Conclusion: Inhibition of miR-21-5p resulted in significant upregulation of lncRNA-XIST and apoptosis-associated genes bax and p53, which led to the induction of apoptosis in MCF-7 cells. Therefore, more investigations may provide a valuable target for studies on molecular therapies for BC.
Determining Effective Factors Regarding Weather and Some Types of Air Pollutants in Seasonal Changes of PM10 Concentration Using Tree-Based Algorithms in Yazd City
Authors: Ebrahimi-Khusfi Zohre , Ebrahimi-Khusfi Mohsen , Nafarzadegan Ali Reza , Soleimani-Sardo Mojtaba 
Published: March 2024

Introduction: This study was carried out with the aim of determining weather parameters and air pollutants affecting seasonal changes of particulate matter of less than 10 microns (PM10) in Yazd city using Random Forest (RF) and extreme gradient boosting (Xgboost) models.
Materials and Methods: The required data was obtained from 2018 to 2022. Levene’s test was applied to investigate the significant difference in the variance of PM10 values in 4 different seasons, and Boruta algorithm was used to select the best predictive variables. RF and Xgboost models were trained using two-thirds of the input data and were tested using the remaining data set. Their performance was evaluated based on R2, Root Mean Squared Error (RMSE), Mean Absolute Error (MAE), and Nash–Sutcliffe Model Efficiency Coefficient (NSE).
Results: The RF showed a higher performance in predicting PM10 in all the study seasons (R2 > 0.85; RMSE < 22). The contribution of dust concentration and relative humidity in spring PM10 changes was more than other variables. For summer, wind direction and ozone were identified as the most important variables affecting PM10 concentration. In the autumn and winter, air pollutants and dust concentration had the greatest effect on PM10, respectively.
Conclusion: RF model could explain more than 85% of PM10 seasonal variability in Yazd city. It is recommended to use the model to predict the changes of this air pollutant in other regions with similar climatic and environmental conditions. The results can also be useful for providing suitable solutions to reduce PM10 pollution hazards in Yazd city
The moderating role of perceived social support in relationship between workplace violence with post-traumatic stress disorder symptoms among nurses in Karbala
Authors: AA Kamel , A Mehdad , A Abdulkadhim Johni , I Sajjadian 
Published: March 2024

Introduction: The presence of violence in workplace is a threatening factor for nurses’ psychological health. Therefore, the present study was conducted with the aim of determining the moderating role of the perceived social support in relationship between workplace violence (physical, Verbal and sexual harassment) with Post Traumatic Stress Disorders symptoms) PTSD( among nurses in Karbala city, Iraq.
Materials and Methods: Research method was descriptive correlation that is used in hierarchical regression analysis. The statistical population of the research included all the hospital nurses of the city of Karbala in Iraq in summer 2023, which among them, 349 nurses were selected by convenience sampling method. The data were collected using the violence in workplace questionnaire, Post Traumatic Stress Disorders symptoms checklist and perceived social support questionnaire. To analyze data, Pearson's correlation coefficient and hierarchical regression analysis statistical tests were used by SPSS software, 26 version.
Results: The results revealed that the perceived social support moderates the relationship between the violence in workplace (physical, verbal and sexual harassment) with post-traumatic stress symptoms (p<0.01). This means that, when the perceived social support is low, the hostility at workplace (physical, verbal and sexual harassment) has a stronger relationship with post-traumatic stress symptoms (p<0.01).
Conclusion: Based on the results of the present study, it can be concluded that the perceived social support in necessary variable to prevent the destructive effects of violence in nurses' work settings. Therefore, due to the role and importance of perception of social support among nurses, attention to this important finding should be taken into consideration by managers and policy makers of healthcare organizations.
Evaluation of the effect of ergonomic educational intervention on working condition correction and reduction of musculoskeletal disorders in office workers
Authors: N Ghasemi , G Halvani , H Falah , A Najafipour , M Ghasemi 
Published: March 2024

Introduction: The growing trend of office workers and the use of computers in these workstations has caused an increase in the prevalence of musculoskeletal disorders among them. Most of the studies have emphasized the need for interventions to improve the ergonomics of office workstations. Therefore, the present study was conducted to investigate the effect of ergonomic training intervention on improving working conditions and reducing musculoskeletal disorders in office workers.
Materials and Methods: The present research is a descriptive-analytical and correlational study. The statistical population of the study is all the employees of the administrative staff of Shuttle Company, according to the criteria for entering and exiting the study, 130 people participated in this study. After the initial evaluation of the work situation, the ergonomic training intervention program was presented to the employees of the company to reduce the musculoskeletal injury factors for two months. The physical condition was evaluated before and after the training. Data collection tools included the Nordic Musculoskeletal Disorders Evaluation Questionnaire (NMQ) and the ROSA posture evaluation method. The data was analyzed by SPSS software; descriptive statistics and Student's t-test were used for statistical analysis.
Results: The results of the study showed that the relationship between musculoskeletal disorders in different age groups is not significant in most body organs and only this relationship has been confirmed in the neck and upper back area. However, the relationship between skeletal and muscular disorders and employees' work history is not significant in most body parts, and only this relationship has been confirmed in the neck and upper back area. Finally, the ergonomic training of the studied subjects has had a significant impact on their calculated risk level (using the ROSA method).
Conclusion: Although most companies have equipment with the necessary ergonomics, employees do not know how to use them correctly. Due to the lack of knowledge of some managers and employees about the importance of ergonomics, it is better to provide these people with the necessary training in this field in addition to creating a work environment by the principles of ergonomics.
RELATO DE EXPERIÊNCIA
Authors: Viana Pamela Rayssa Silva Pinho , Santos Eliane Pereira , Silva Maria Francisca da 
Published: March 2024

O presente trabalho trata-se de um relato de experiência sobre oficinas de leitura e produção textual do gênero poema visual, na modalidade de ensino remoto. A pesquisa objetiva analisar a importância de aplicativos digitais, tais como, WhatsApp, Quiz e Padlet, nas aulas de Língua Portuguesa, no Ensino Fundamental. Como desdobramento do objetivo geral, temos os seguintes objetivos específicos: a) relatar atividades de leitura e produção textual do gênero poema visual realizadas a partir de aplicativos digitais, na Educação Básica, em turmas de 9º ano do Ensino Fundamental; b) discutir a importância dos multiletramentos, dentre eles, o letramento digital nas práticas de leitura e de escrita; c) relacionar o letramento literário com o letramento digital, como forma de aproximar a escola das práticas linguageiras da contemporaneidade digital. Diante disso, temos como questão problema: como os recursos digitais podem contribuir com estratégias de leitura e produção textual na educação básica? A metodologia consta de um relato de experiência sobre a realização de oficinas de leitura e produção textual do gênero poema visual, usando aplicativos digitais. As atividades foram desenvolvidas com alunos do ensino fundamental, na cidade de São Bernardo-MA. Dentre as técnicas de pesquisa utilizadas, destacamos a observação no contexto escolar, e a análise de textos de alunos, produzidos nas oficinas, por meio de aplicativos digitais, tais como: Padlet, Quiz, WhatsApp. As discussões propostas nos ajudam a entender como os aplicativos digitais contribuem para o desenvolvimento de multiletramentos nas aulas de Língua Portuguesa.
Isınma Seanslarında Uygulanan Eğitsel Oyunların Fiziksel ve Psikolojik Performansa Etkileri
Authors: ÜÇÜNCÜ Halim , EDİS Çağlar 
Published: March 2024

Amaç: İyi bir ısınma seansı sporcuları fizyolojik ve psikolojik olarak hazırlamalıdır. FİFA11+ gibi ısınma seansları eğlenceli bir ortamdan ziyade daha ciddi bir ortamda uygulanmaktadır. Bu ısınma seansının akut performans üzerine etkisinin olumlu olmadığı açıkça belirtilmektedir. Bu araştırmanın âmâcıda FİFA 11+ ısınma seansının eğitsel oyunlar ile uygulanması (FİFA 11+ EO) sonrası akut fiziksel ve psikolojik performans değerleri üzerine etkilerini incelemektir.
Yöntem: Araştırmaya yaşları 16 olan toplam 15 iyi antrene edilmiş futbol oyuncusu dâhil edildi (boy: 168,2667±7,43, Kilo: 55,2667±8,12814, Vki: 19,5007±2,03426). İlk aşamada FİFA 11+ ısınma seansı uygulaması sonrası 20 mt sürat, 505, T diril ve illinois yön değiştirme koşu (YDK) testleri uygulanıp hemen ardından fiziksel aktiviteden keyif alma ölçeği (FAKÖ) dolduruldu. Bu uygulamadan bir hafta sonra FİFA 11+ EO ısınma seansı gerçekleştirip aynı testler birer gün ara ile uygulandı.
Bulgular: Elde edilen veriler normallik testlerine göre karşılaştırma analizlerine dâhil edildi. FİFA 11+ ısınma seansı sonrası sporcuların 20 mt sürat zamanlarında FİFA 11+ EO ısınmasına göre anlamlı farklılık elde edildi (p
Quality of life for adult family caregivers of patients with dementia: a Systematic review
Authors: Aungsuroch Yupin , Juanamasta I Gede , Elsherbiny Ola Ebrahim , Kabaya Sonoko 
Published: March 2024

Introduction: to evaluate problems and factors related to quality of life (QoL) for adult family caregivers (FCGs) of patients with dementia.
Methods: The study used a systematic review method with the guidelines of PRISMA 2020 and registered in PROSPERO CRD42023464726. The review focused on adult FCGs for people with dementia in the home setting. The literature was searched from four databases, including Scopus, Web of Science, CINAHL, and PubMed. This systematic review examined a subset of fifty-two out of a total of 2,263. The study used a narrative synthesis method to analyze the study.
Results: The result showed that the severity of a patient with dementia’s condition had an essential role in the patient's state. It impacted the caregiver's condition indirectly. Personal strategies (coping, resilience, sense of coherence, and expressed emotion) had an essential role in the caregiver situation. A maladaptive strategy would increase the stress of the caregivers and lead to a burden and depression. Those conditions of the caregiver would affect their QoL.
Conclusions: Caring for patients with dementia is a huge psychological distress and burden on FCGs, which may negatively affect their quality of life in many aspects. Therefore, FCGs need education and support programs to maintain their overall aspect of quality of life and enable them to produce care for loved people.
Traditional Massage-Induced Iliotibial Band Syndrome: A Case Report
Authors: Nugroho Nunung , Andriani Bernadheta Ayu 
Published: March 2024

Iliotibial Band (ITB) Syndrome is common among athletes, such as runners and cyclists. There are several theories regarding the etiology of ITB Syndrome, including friction, compression, and chronic inflammation. We report a rare case of ITB Syndrome induced by traditional massage after a history of chronic knee pain. A 63-year-old female visited our Pysical Medicine and Rehabilitation Department with the pain of the lateral side of the right knee for four months after traditional massage. The physical examination showed a positive Ober test and Noble compression test. We performed an ultrasonography on the lateral right knee and found fluid effusion beneath the ITB confirming the diagnosis of ITB Syndrome. A pain intervention was performed with ultrasound-guided aspiration and injection of steroid beneath the ITB. After the procedure and rehabilitation program of cryotherapy and ultrasound therapy, the pain was reduced greatly and there was no need for further management.
Performances Performances de la population de poissons indigènes dans le réservoir PB Soedirman, Banjarnegara, Indonésie
Authors: Sukiyati Eny , Soedibya Petrus Hary Tjahja , Sulistyo Isdy 
Published: March 2024

Le réservoir de PB. Soedirman est une zone lentique constituant un habitat pour divers de poissons. Le but de cette étude était d'inventorier les espèces, la dominance, l'abondance, et la biomasse relative des poissons indigènes dans le réservoir. Une méthode d'enquête a été effectué dans 7 stations d'échantillonnage avant d’obtenir les données primaires, c’est à dire la diversité des espèces de poissons. Les résultats ont montré qu'il y avait 13 poissons indigènes. L’indice de diversité était de 1,15 ; alors que l'indice de dominance a touché 0,03 indiquant une faible dominance. L'abondance relative des poissons était de 40,75 %, et la biomasse relative 40,12 %.
A Generalized Method for Dynamic Fracture Characterization Using Two-Phase Rate Transient Analysis of Flowback and Production Data
Authors: Sun Guoqing , Zhang Zhengxin , Mu Changhe , Liu Chuncheng , Deng Chao , Li Weikai , Hu Weiran 
Published: March 2024

Summary
This study presents a comprehensive method for characterizing reservoir properties and hydraulic fracture (HF) closure dynamics using the rate transient analysis of flowback and production data.
The proposed method includes straightline analysis (SLA), type-curve analysis (TCA), and model history matching (MHM), which are developed for scenarios of two-phase flow in fracture, stimulated reservoir volume (SRV), and nonstimulated reservoir volume (NSRV) domains. HF closure dynamics are characterized by two key parameters, which are pressure-dependent permeability and porosity controlled by fracture permeability modulus and compressibility. The above techniques are combined into a generalized workflow to estimate iteratively the five parameters (including four optional parameters and one fixed parameter) by reconciling data in different domains of time (single-phase water flow, two-phase flow, and hydrocarbon-dominated flow), analysis methods (SLA, TCA, and MHM), and phases (water and hydrocarbon phase).
We used flowback and production data from a shale gas well in the US and a shale oil well in China to verify the practicability of the method. The analysis results of the field cases confirm the good performance of the newly developed comprehensive method and verify the accuracy in estimating the static fracture properties [initial fracture pore volume (PV) and permeability] and the HF dynamic parameters using the proposed generalized workflow. The accurate prediction of the decreasing fracture permeability and porosity, fracture permeability modulus, and compressibility demonstrates the applicability of the comprehensive method in quantifying HF dynamics. The field application results suggest a reduction of the fracture PV by 15% and 20%, and a reduction of the fracture permeability by 80% and 90% for shale gas and shale oil wells, respectively.
Multimodal Joint Representation by Shared Knowledge Embedding with Vision-Language View for VQA
Authors: Cheng Keyang , Jiang Zhou , Si Yu , Ding Yi , Gu Hongjian , Ghafoor Humaira abdul 
Published: March 2024

Abstract

Current works in Visual Question Answering(VQA) that introduce external knowledge mainly focus on leveraging the knowledge to supplement the language representation in VQA model’s question input. However, such approaches ignore the commonsense information implied in the image. In this paper, we propose a novel VQA framework to embed knowledge features into vision and language respectively with a shared knowledge graph. To bridge the gap between visual representation and knowledge representation, we propose the knowledge enhancing visual representation (KEVR) module. KEVR is designed to explore external knowledge in image from the knowledge graph. By utilizing KEVR, external knowledge related to the objects in the image can be embedded into visual representation directly. In terms of the input question, a designed transformer is utilized to embed knowledge features into language representation. The knowledge graph used in our model is extracted from three knowledge bases. We organize the prior knowledge in the form of RDF triples to establish knowledge connections, then a graph neural network is employed to extract multilateral relationships in knowledge graph. What's more, a two-stream transformer is employed to get the attention based vision-language representation. The results of our experiments show that our model outperforms the best baseline model with an accuracy of 1.34% and 2.59% on VQA 2.0 and OK-VQA datasets respectively.
Designing a Recommendation Model by Dilated Convolutional Neural Network with Bi-Directional Gated Recurrent Unit
Authors: G Jai Arul Jose , Mastan Mahammad , Al-Nuaimy Louay A. Hussein 
Published: March 2024

Abstract

In recent years, the recommendation system is one of the important tools of e-commerce, which provides suggestions to the user for some resources such as hotels, songs, books, movies, etc. The existing hotel recommendation method has faced many problems such as data sparsity, cold-start problems, scalability, etc. So, this paper proposes the hotel recommendation system use the hybrid of dilated convolutional neural network (CNN) and bi-directional gated recurrent unit (BiGRU) with an attention mechanism. The main aim of this research is to develop a more efficient, scalable, regularized, and more generalized recommendation system which can recommend the name of the hotels to the travellers based on their preferences by analysing the previous so far traveller’s comments together with the rating value to improve the forecast accuracy. The aspect based attention mechanisms are employed to evaluate the word, sentence, and semantic level similarity weight based vectors for mining useful information. The proposed approach has shown improved performance than existing approaches in terms of 99.46% Accuracy, 98.94% Precision, RE98.84% Recall, and 98.75% F1-score.
Risk Factors of Sexual Abuse among School-Going Children in Primary Schools in Kisumu County, Kenya
Authors: Maranga Isabel , Onyango Patrick , Omondi Dickens 
Published: March 2024

Abstract
Child sexual abuse is a public health problem with negative physical, mental, behavioral and learning outcomes to survivors. A recent Kenya Demographic Health Survey showed that 22% of women and 13% of men in western Kenya have experienced sexual abuse compared to 14% women and 6% men nationally. Whereas schools have a major influence on a child’s development and behavior, they have been identified as important settings where child sexual abuse might occur. However, how sexual abuse is patterned by the type and location of the school remains an open question. In the present study, we investigated risk factors of sexual abuse among school-going children in primary schools in Kisumu County. Using a cross-sectional study design and guided by the ecological health model, the study determined association between type of school and sexual abuse; association between location of school and sexual abuse, and spaces that predispose school-going children to sexual abuse in primary schools. A sample of 398 pupils aged between 10–16 years randomly identified participants from 37 pre-selected primary schools in Kisumu Central and Kisumu West sub-Counties was used. Data from pupils was collected using self-administered questionnaires, focus group discussions, and key informant interviews. The mean age of participants was 13 years. Forced sex (38%) was the most common known type of sexual abuse. More girls than boys had ever experienced any type of sexual abuse 29% versus 20%; p = 0.038. Whereas there was no statistical difference in pupils’ experience of sexual abuse by type and location of school x2 = 2.044; p > 0.05 and x2 = 0.823 p > 0.05, pupils reported that attending public day schools is associated with higher risk of sexual abuse mainly while walking to and from home. Pupils reported that bushes inside the school (52%), latrines/toilets (51%) and bushes outside the school (50%) were the spaces where one is more likely to experience sexual abuse. Being a female pupil was the most significant risk factor for sexual abuse in the primary schools surveyed indicating that gendered predisposition plays an important role in the incidences of sexual abuse in primary schools. Though not statistically significant in this study, it is plausible that risky spaces and type of schools might modify female gender predisposition in subtler ways as suggested from the pupils’ perspectives. Consequently, there is need for a gendered focus in a complex primary schooling environment.