bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antigenic differences among B16 melanoma variants selected for their differing abilities to metastasize: A possible mechanism for effective adjuvant immunotherapy
Authors: Steele Glenn , Wang Bosco Shang , Ghavamzadah Giti , Fallon Marguerite , Richie Jerome , Wilson Richard E. , Mannick John A. 
Published: February 2007

AbstractMost C57BL/6J mice will develop pulmonary metastases four to six weeks after excision of B16 melanoma isografts and begin to die within 40 days. When applied in an adjuvant setting after isograft excision, specific B16 immune RNA (I‐RNA) therapy prevents pulmonary metastases and prolongs survival in 50% of treated animals. Since increased in vitro cell‐mediated cytotoxicity (CMC) against B16 targets has been demonstrated in animals whose survival is improved by B16 I‐RNA therapy, we have proposed that the treatment functioned, at least in part, by specifically altering host CMC in vivo. In this study, C57BL/6J splenocytes were specifically sensitized in vitro by B16 I‐RNA exposure and examined for cytotoxic effect on variants of B16 melanoma selected for their differing metastatic potential in vivo. F10 tumor targets (explanted from a B16 melanoma vairant producing frequent pulmonary metastases in vivo) were consistently more sensitive to specific in vitro cytotoxic effect than F1 target cells (from a B16 melanoma variant with low metastatic potential in vivo). Lung metastases (F1 mets) were explanted after intravenous (IV) injection of F1 and used as target cells in the in vitro CMC assays. F1 mets demonstrated greater cytotoxic effect than F1 targets after exposure to B16 I‐RNA‐treated syngeneic splenocytes. C57BL/6J mice were sacrificed at weekly intervals following adjuvant in vivo B16 I‐RNA therapy (after B16 isograft excision), and their splenocytes were shown to be consistently more cytotoxic in vitro to B16 and F10 than to F1 target cells. Splenocytes harvested from mice treated with I‐RNA specific to antigenically distinct Lewis lung carcinoma (3LL) after 3LL isograft excision had no cytotoxic effect on any of the B16 variants. When nonsensitized C57BL/6J splenocytes were examined for cytotoxic effect in natural killer (NK) assays or in NK inhibition assays, differences in cytotoxic sensitivity of B16, F10, F1, and F1 mets could not be demonstrated. We conclude, therefore, that specifically sensitized effector cells could distinguish antigenic differences among B16 variants selected for differing in vivo metastatic potiential. These differences were tumor specific and could be demonstrated by cytotoxic splenocytes after either in vivo B16 I‐RNA treatment or in vitro B16 I‐RNA exposure. The relationship of these antigenic differences to in vivo metastatic potential and to the effectiveness of adjuvant B16 I‐RNA therapy is discussed.
An analysis of percutaneous transhepatic cholangiograms
Authors: Park Hyung C. , Choi Sung H. , Nava Hector , Jennings Ethelyn C. 
Published: February 2007

AbstractPercutaneous transhepatic cholangiograms (PTCs) of 74 cancer cases with obstruction of the biliary tree were reviewed and evaluated as to the location, degree of obstruction, and location of the obstructing elements ie, intra‐luminal polypoid intrusions and diffuse infiltration. Special attention was given to the diagnostic value of the sign of an extrinsic compressing mass, a disputed entity. Every one of the above parameters, including extrinsic mass compression effect, proved to be worthwhile in arriving at a reasonable diagnosis. A system for coding obstructions to give maximum information in minimum space for large series of cases and to improve diagnostic accuracy of PTC in the single case is presented.
Enhancement of metastasis development by BCC lmmunotherapy
Authors: Colmerauer Maria E. , Koziol James A. , Pilch Yosef H. 
Published: February 2007

AbstractWhen BALB/c mice bearing growing transplants of a syngeneic colon carcinoma ‐ Colon Tumor 26 (CT 26) ‐ were treated with Bacillus Calmette‐Guerin (BCG), no effect on tumor growth rate or survival time was observed compared to untreated controls. However, after excision of primary tumor transplants, enhanced development of lung metastases was noted in the BCG‐treated mice, resulting in both an increased mortality rate (from metastatic disease) and a shorter survival time.
Hospital‐based cancer detection programs for the community
Authors: Mettlin Curtis , Kizilbash Mehdi , Michalek Arthur 
Published: February 2007

AbstractExperimental screening programs have demonstrated the efficacy of screening procedures for cervical, breast, and colorectal cancers but there has not been widespread application of such screening projects to programs suited to community health care facilities. Here, we illustrate how this may be accomplished by use of outpatient facilities, cancer screening clinics in hospitals, or periodic short‐term community screening programs. The objective is cancer control through screening and detection programs characterized by application of demonstrated detection procedures, reliance on existing hospital resources, use of minimally invasive screening procedures, promotion targeted to high‐risk groups, collaboration with community volunteer organizations, and emphasis on serving persons not already receiving such routine detection services. This paper presents results on the hospital monitoring of Pap smear screening of outpatients and the yield from experience with the community screening program. It also describes the various cancer control activities of an ongoing hospital‐based cancer screening clinic.
Adjunctive management of thyroid cancer: Chemotherapy
Authors: Shimaoka Katsutaro 
Published: February 2007

AbstractThe majority of well‐differentiated carcinoma of the thyroid can be effectively treated by surgery and thyroid hormone administration, or in combination with radioiodine therapy. Occasional patients with well‐differentiated carcinoma, and patients with medullary carcinoma and anaplastic carcinoma should be considered for chemotherapy. Doxorubicin has been shown to be active in this neoplasm. In addition, there are chemotherapuetic agents shown to be active in small numbers of patients with this disease, but most of them have not received an adequate trial. Multiple‐agent chemotherapy has also been tried in this disease. However, average response rate of multiple‐agent chemotherapy appears to be only slightly better than that of doxorubicin single‐agent chemotherapy. The importance of group approach in evaluating chemotherapy program is presented.
Pleomorphic giant cell carcinoma of the pancreas: A review of nine cases
Authors: Reyes Cesar V. , Crain Sidney , Wang Taishine 
Published: February 2007

AbstractNine cases of pleomorphic giant cell carcinoma of the pancreas collected over a 26‐year period are analyzed. The tumor presents a distinctive histology. The head of the pancreas appears to be the predominant site of the lesions in this study, and the cell origin is considered to be the ductal epithelium. Its clinical manifestation and rapid, fatal course of usually two months are almost indistinguishable from the more conventional pancreatic adenocarcinoma.
Second primary lung carcinoma
Authors: Sulkes Aaron , Naparstek Yaakov , Shalit Meir , Kopolovic Juri 
Published: February 2007

AbstractLong‐term survivors with bronchogenic carcinoma represent only a small fraction of the overall population affected with this disease. Therefore, the occurrence of a second primary lung carcinoma is a rare event and can be diagnosed either simultaneously, or, more frequently, sequentially. A review of the literature disclosed a median interval of five years between metachronous lesions with a range of 0 to 16 years. We thus consider it of interest to report a case in which 17 years had elapsed between the first tumor, successfully treated by a lobectomy, and the diagnosis of a second primary tumor located in the contralateral lung.The literature on second primary lung tumors is reviewed and the histo‐pathological aspects, as well as the therapeutic implications, of this relatively rare condition are discussed.
Combination therapy for advanced malignant melanoma with BCNU, pseudomonas vaccine, and heparin
Authors: Snyder R. D. , Hortobagyi G. N. , Bodey G. P. , Gutterman J. U. , Hersh E. M. 
Published: February 2007

AbstractA study was undertaken to investigate the addition of heparin and pseudomonas vaccine to BCNU in the treatment of patients with progressive malignant melanoma refractory to front‐line therapeutic regimens containing DTIC. Out of 27 evaluable patients, there was one partial remission (4%), and an additional ten patients (41%) had at least stable disease with a median survival time of 39 weeks compared to 15 weeks for those with progressive disease. The therapy was well tolerated. A schedule of pseudomonas vaccine that seemed to be tolerated has been established.
Carcinoma of breast associated with pregnancy and lactation
Authors: Sahni K. , Sanyal B. , Agrawal M. S. , Pant G. C. , Khanna N. N. , Khanna S. 
Published: February 2007

AbstractOut Of 840 Cases Of Breast Carcinoma Seen Over A Period Of Ten Years, 18 Were Found To Be Associated With Pregnancy And Lactation. According To The Mode Of Onset And Presentation Of The Disease, These Patients Were Divided Into Four Groups. The Average Age Of These Patients Was 31.9 Years Old. Thirteen Out Of 18 Patients Presented In A Very Advanced Stage Of The Disease. In A Short Period, Involvement Of Liver Was Noticed In 8, Brain In 3, And Bones And Lung In 2 Each. The Disease Was Bilaterally Simultaneous In Two Patients. The Acceleration Of Growth Was Noticed During Second And Third Trimesters Of Pregnancy As Well As During Lactation. The Termination Of Pregnancy In Three Patients Did Not Alter The Clinical Course Of The Disease.
Wilms tumors in adults
Authors: Abadir Rushdy 
Published: February 2007

AbstractA 63‐year‐old man had an unresectable metastatic Wilms tumor in the right kidney. Radiotherapy to the abdomen and chest wall as well as chemotherapy in the form of actinomycin D, vincristine, and cyclophosphamide was given. The tumor was radioresponsive but failed to respond to chemotherapy. The literature was reviewed. Other reported cases of Wilms tumor in adults treated with chemotherapy that is usually given to children are few, but the results are mostly disappointing.
Immunological significance of lymphoreticular infiltration in gastrointestinal cancer
Authors: Gupta S. , Seth S. K. , Udupa K. N. , Sen P. C. , Rastogi B. L. 
Published: February 2007

AbstractThe 60 patients of gastrointestinal cancer comprising this study were in the age range of 29–70 years with 39 males and 21 females. The primary sites of cancer were: gallbladder 19, colon 13, stomach 12, anorectum 8, and liver 8. The stage of tumor spread was localized in 32 and metastatic in 28 cases. Round cell infiltration scores were classified semiquantitatively from O‐V. Cellular immunity as expressed by the blood lymphocyte count and DNCB reactivity was also studied. Round cell infiltration was dense in the localized group (P < 0.0005). The mean lymphocyte counts in all the primary sites of gastrointestinal cancer were significantly higher in the localized group as compared to metastatic group. The DNCB reactivity showed anergy in six cases and poor response in the remaining 22 cases of metastatic group. There was a statistically significant correlation between lymphoreticular infiltration, peripheral blood lymphocyte count, and the DNCB reactivity. Diminished round cell infiltration, lymphopenia, and depressed DNCB response indicate an advanced stage of gastrointestinal cancer.
Uterine sarcoma following adjuvant radiotherapy for rectal carcinoma
Authors: Marmion Patrick J. , Goldfarb Paul M. , Youngkin Tyler P. 
Published: February 2007

AbstractSince adjuvant radiotherapy for rectosigmoid carcinoma appears to improve prognosis, the importance of delayed side effects such as radiation‐induced malignant disease must be considered. The present report describes the first reported case of the development of a uterine carcinosarcoma more than 9 years after preoperative radiotherapy to the midpelvis for rectal carcinoma.
The pathologist's role in a multidisciplinary approach for soft part tissue sarcoma: A reappraisal (39 cases)
Authors: Mandard A. M. , Chasle J. , Mandard J. C. , Rousselot P. , Boulier N. , Vernhes J. C. , Wyplosz J. , Alperine S. , Tanguy A. , Abbatucci J. S. 
Published: February 2007

AbstractA combined treatment modality of radiotherapy, surgery, and monochemotherapy in 39 cases of soft tissue sarcomas is presented. The 39 patients presented initially with local disease only, without evidence of metastases. At the end of the surgical procedure the adequacy of the excision had been evaluated by the pathologist. Surgical procedure was complemented by systematic radiation therapy. The overall recurrence rate was 7.7%; the overall incidence of metastases 31%. In the group in which adequate excision had been obtained, no loco‐regional recurrences were obtained, survival was significantly better, and the incidence of metastases was lower than in the group in whom adequate excision could not be obtained. The importance of two criteria was stressed: the depth and the character of the margins of the tumor which cannot be considered separately. The results suggest that there is a correlation between the general and loco‐regional malignancy of soft tissue sarcomas.
Malignant neoplasms of the major salivary glands
Authors: Lawrence W. Thomas , Lawrence Walter 
Published: February 2007

AbstractBetween January 1, 1968 and December 31, 1978, 42 patients with malignant lesions involving the major salivary glands were seen at the Medical College of Virginia. A 60% 2‐year survival and a 42% 5‐year survival were noted. Histologic type was the major determinant of survival. Symptoms other than a painless mass, a largest dimension greater than 4 cm, older age, and clinical spread outside the gland were all suggestive of both a more malignant histologic type and a worse prognosis. Based on these observations, a plan is proposed for the diagnostic approach and treatment of salivary gland masses that is based on the mode of presentation and histologic findings.
Surgical management of pericardial tamponade as a presenting manifestation of acute leukemia
Authors: Liepman Marcia K. , Goodlerner Susan 
Published: February 2007

AbstractTwo patients with acute leukemia presented with symptomatic acute pericarditis and rapidly developed cardiac tamponade. Conservative management was not possible in either patient due to mechanical problems with fluid removal. Thoracotomy with pericardial decompression resulted in permanent relief of symptoms in both cases. Management of cardiac tamponade in acute leukemia by surgical decompression even in severely immunocompromised hosts is a feasible alternative and should be considered when more conservative measures fail or are not possible.
Correlations between serial CEA levels and surgery in patients with colorectal carcinoma
Authors: Midiri G. , Amanti C. , Benedetti M. , Caliento D. , Consorti F. , Buono S. Del , di Paola M. 
Published: February 2007

AbstractNowadays the evaluation of serial carcinoembryonic antigen (CEA) levels represents an important parameter for the prognosis of patients with carcinoma of the large bowel. Changes in CEA values allow the drawing of conclusions regarding the effectiveness of therapy. We have studied 63 patients with colorectal carcinoma that underwent surgical treatment. Serial CEA levels were tested in each patient before surgery and 15 days after. The 53 patients were considered surgically cured; and among these 7 did not have a significant decrease of CEA values after surgery. The percentage of recurrences among these patients has been 71.4%; meanwhile patients who showed a decrease of CEA values below cutoff values had recurrences only in 17.3% of cases. For this reason is our opinion that patients considered surgically cured who have postoperative high CEA levels cannot be considered really cured from a biological point of view.
Treatment of stage D prostatic carcinoma with megestrol acetate
Authors: Block Margaret , Bonomi Philip , Anderson Kenning , Wolter Janet , Showel John , Pessis Dennis , Slayton Robert 
Published: February 2007

AbstractNine previously untreated patients with stage D prostatic carcinoma received megestrol acetate 40 mg orally three times daily. Responses included five partial regressions, two stabilizations, and two progressions. Duration of response ranged from 3 + to 33 + months, with a mean of 11.7 months and a median of 12 months. Three of five patients who had failed prior hormonal therapy remained objectively stable while receiving megestrol acetate. No gastrointestinal toxicity, gynecomastia, fluid retention, or thromboembolic complications were observed during treatment. Weight gain of 5 to 51 pounds occurred in seven of 14 patients.
Management of the pancreatic remnant in pancreatoduodenectomy
Authors: Papachristou Dimitri N. , Fortner Joseph G. 
Published: February 2007

AbstractOf the various methods used for the management of the remaining pancreas in 70 patients who had pancreatoduodenectomy for cancer, pancreatojejunostomy (P/J) was associated with the lowest morbidity and closure of the remnant with the highest. End‐to‐end and end‐to‐side P/J were equally satisfactory, the use of stents, however, doubled the morbidity. P/J was particularly safe in the presence of a dilated pancreatic duct. Closure of the remnant caused a very high morbidity regardless if the pancreas was closed with sutures or staples. Despite their difference in morbidity, P/J and closure had the same mortality and approximately the same impact on pancreatic function, exocrine as well as endocrine. The study indicated that although closure of the remnant, as it is practiced today, gives results inferior to those obtained with P/J, with some modification it might offer a simple alternative to P/J in the future.
An in vitro clonal assay for bladder cancer: Studies of the biologic potential of the urothelium and determination of in vitro sensitivity to cytotoxic agents
Authors: Stanisic T. H. , Buick R. N. , Trent J. M. , Fry S. E. , Salmon S. E. 
Published: February 2007

AbstractWe have applied an in vitro colony‐forming assay system to the study of primary urothelial explants obtained transurethrally by bladder barbotage and tumor biopsy from 91 patients. Urothelial cells obtained by bladder barbotage from patients with bladder cancer and from a “control” group of individuals exhibit differential capacity to clone in agar. Of samples from bladder cancer patients, 88% formed colonies, whereas only 27% of these from a “control” group did so. Of samples from a “suspicious” patient group, 70% formed colonies. In vitro drug sensitivity studies of cells obtained by biopsy of solid tumors demonstrate a spectrum of drug sensitivity to cytotoxic agents.
Increased pyrophosphate rib uptake: Clinical correlation
Authors: Talarico Louis J. , Shalaby Omar F. O. , Abdel‐Dayem Hussein M. , Leslie Eugene V. 
Published: February 2007

AbstractTwo hundred and thirty‐one patients had 270 bone scans. Increased rib uptake was correlated with radiological findings. Interpretation of results whether due to benign or to metastatic disease depends on other observations. These include whether the uptake is localized or along the rib outline, single or multiple, and associated with other abnormal uptake in the rest of the skeleton. Abnormal rib uptake was encountered in 23% of patients scanned for malignant disease and 10% of patients scanned for benign conditions.In the first group 34% were true positive and of these, rib lesions were multiple in 32% and solitary in 2%. In 20% the rib uptake was due to benign conditions and in 46% it was indefinite because of absent radiological findings. In this last difficult group 17% were due to probably early rib metastases and 29% were due to benign causes. Rib metastases were missed in only two cases, 1.1%. One case was multiple myeloma and the other was direct extension from underlying anaplastic lung carcinoma.
Histiocytic lymphoma presenting with portal hypertension and bleeding esophageal varices: A case report
Authors: Salem Philip A. , Tabry Imad , Parsi Mohammed , Brihi Emile 
Published: February 2007

AbstractAn unusual case of histiocytic lymphoma presenting with portal hypertension and bleeding esophageal varices is reported. Laparotomy revealed bulky nodal disease in the portahepatis compressing the portal vein, common bile duct, hepatic artery, and cystic duct. Liver was free of tumor, and there was no evidence of extra‐abdominal disease. Radiation therapy to the right upper quadrant of the abdomen produced a transient remission for one month, followed by relapse in mediastinum and both lung hilae.
Metastasis of sarcomatous lesion in regional lymph node
Authors: Lee Yeu‐Tsu N. , Moore Tillman M. , Schwinn Charles P. 
Published: February 2007

AbstractThis is a retrospective study of 390 patients with early sarcoma admitted over a 13‐year period. There were 182 bone lesions, 173 soft tissue sarcomas, and 35 visceral sarcomas. Two hundred ninety‐two patients had surgical resections, and 77 had specimens of lymph node(s) examined histologically. Among the latter group, 6 of 47 patients with non‐osseous sarcomas (13%) had metastasis in the regional node initially (subtypes include fibrohistiocytoma, leiomyosarcoma, rhabdomyosarcoma; synovial, anaplastic, and Kaposi sarcoma). Another two patients developed nodal metastasis subsequently (rhabdomyosarcoma). Among the 30 patients with skeletal sarcomas who had lymph nodes removed during resection, one case with osteogenic sarcoma and one chondrosarcoma had nodal metastasis initially (7%). During follow‐up, one patient with Ewing's sarcoma and another with chondrosarcoma developed regional lymphadenopathy. Our findings are discussed and compared with incidences of metastatic sarcomatous lesion in lymph node reported in the literature.
Cystotomy and peroperative irradiation for bladder cancer: Long‐term results
Authors: Appelqvist Pertti , Salmo Matti 
Published: February 2007

AbstractThe long‐term results were investigated in 46 patients of bladder cancer treated by cystotomy and peroperative irradiation. This combination therapy appears to produce grossly comparable long‐term survival results with surgery and radiotherapy. There were ten complications during a ten‐year period after the treatment.We think that cystotomy and peroperative irradiation could still be used for the treatment of bladder cancer especially when the tumor is not too large, is situated at the base of the bladder, and segmental resection cannot be performed, and the patient wants to spare the bladder function.