bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triglyceride-glucose Index as a Novel Early Risk Predictor for Cardiovascular Disease in Type 2 Diabetes Mellitus Patients with Hypertension
Authors: Raj Neelima , Harley Kumud N. , Nandedkar Prerna 
Published: February 2025

Abstract

Background:
Type 2 diabetes mellitus (T2DM), marked by insulin resistance or deficiency, and hypertension (HTN), a diabetic risk factor, elevates cardiovascular disease (CVD) risk. Traditional lipid profiles may be inconclusive; hence, the emerging triglyceride-glucose (TyG) index serves as a feasible biomarker for early CVD risk prediction. This study assesses TyG index utility in predicting early CVD risk among hypertensive T2DM patients.

Methodology:
An observational study was conducted on T2DM patients (n = 100) with age >40 years, attending a medical outpatient clinic in a tertiary health-care center, Akola, and the subjects were categorized as Group I with 50 participants with hypertensive DM and Group II with 50 nonhypertensive diabetic participants. The laboratory investigations, including fasting blood sugar (FBS), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), and very LDL-C, were estimated. Appropriate statistical analysis was applied and the TyG index was calculated by the formula: Ln (fasting TG [mg/dL] × fasting blood glucose [mg/dL]/2) 3.

Results:
In the present study, a total of 100 participants examined who were with DM. These participants were divided into two groups. In both groups, out of 50 participants, 25 were male and 25 were female participants. The mean ± standard deviation of the TyG index was 5.08 ± 0.10 for the DM with HTN group, whereas it was 4.97 ± 0.30 for the DM without HTN group. This difference was statistically significant with P < 0.0001. In addition, significant associations were observed between the TyG index and various cardiovascular risk factors, including systolic blood pressure (BP), diastolic BP, FBS, TG, and LDL-C, with a P = 0.0001.

Conclusion:
The study concluded that the TyG index might serve as an early screening tool to calculate CVD risk in addition to routine lipid parameters.
Assessment of Quality of Life among Patients with Knee and Hip Osteoarthritis Attending the Orthopedic Outpatient Department of Tertiary Care Hospital in Mysore
Authors: Divitha N , Shree Amogha 
Published: February 2025

Abstract

Background:
Osteoarthritis (OA) is a chronic degenerative joint disease that significantly impacts the quality of life (QoL) of affected individuals. Understanding the QoL experienced by patients with knee and hip OA is crucial for developing targeted interventions and improving overall patient care. The objective is to assess the QoL of patients with knee and hip OA attending the orthopedic outpatient department of tertiary care hospital in Mysore.

Methods:
This cross-sectional study was conducted over 6 months in the orthopedic OPD consisting of patients diagnosed with knee and hip OA. Data were collected using a semi-structured questionnaire that included sociodemographic characteristics, clinical factors, and the World Health Organization QoL-BREF questionnaire. The study employed descriptive statistical measures for data analysis.

Results:
The study included 181 participants. Females constituted 63.5%, the majority were in the 51–60 years age group (39.8%), 39.8% had completed graduation, 46.4% were unemployed, and 69.1% were from rural backgrounds. Overweight was noted among 61.3%, bilateral knee OA was present in 45.3% of patients, and 82.3% were diagnosed within 6 months. Hypertension and diabetes were seen among 60.2% and 58%, respectively. The findings demonstrated variations in QoL across domains, with the mean score of the social relationships domain of 49.76 and the physical health domain score of 37.98.

Conclusion:
The findings highlight the low physical domain mean score and high social relationship mean score. The overall QoL is almost equally distributed as low and high QoL.
Adapting to the Virus: Assessing the preparedness of Urban Slum Population in the Context of JN1 Variant of COVID-19 - A Cross-sectional Study
Authors: Shree Amogha , Rashmi S. , Khader M. Sana , Kumar D. Sunil 
Published: February 2025

Abstract

Background:
The World Health Organization’s declaration of the JN1 COVID-19 strain as a “variant of interest” owing to its worldwide rapid upsurge of infected cases, had called on all nations to review their level of preparedness.

Objective:
The objective of the study was to assess the knowledge, attitude, and practices regarding the COVID-19 JN1 variant among the general population in an urban slum of Mysore.

Methodology:
A cross-sectional study was conducted in the urban slum of Mysore for 2 months during the outbreak of the COVID-19 JN1 variant from December 2023 to January 2024, using a convenient sampling method. Data were collected using pretested semi-structured questionnaire among 120 adults above 18 years.

Results:
Good knowledge was observed among 90.8% of the participants, a positive attitude among 80.8%, and half of them (50.8%) had good practice. The majority, i.e., 67.2% mentioned at least one symptom of COVID-19 infection 21% mentioned that they wear mask as a preventive measure against COVID-19. Past infection with COVID-19 directly affected both the knowledge and attitude scores of the respondents. Other factors that influenced the knowledge of participants were the education status and the history of any death in their family due to COVID-19.

Conclusion:
Despite good awareness noted among the participants, awareness regarding COVID-19 and the JN1 variant among the study population was not satisfactory. Health-care workers should focus on advancing knowledge and awareness about COVID-19 to encourage the public to adopt more preventive practices.
Ferroptosis in Tumor Microenvironment: An Alternative Mode of Cell Death and Its Clinical Significance in Cancer
Authors: Paul Paramita , Barik Subhasis 
Published: February 2025

Abstract
Dysregulated cell death plays a vital part in the initiation, progression, and evolution of cancer. While the canonical, programmed cell death pathways have been well characterized in the context of cancer, the growing number of instances of drug-resistant cancer cases requires the identification of alternative cell death mechanisms. Ferroptosis is a recently discovered mode of cell death that depends mainly on the intracellular-free iron pool, not so much on the classical executioner proteins. With iron being an essential macronutrient and a critical regulator of cellular redox activities, how iron is distributed across the heterogeneous population of cells within and around a tumor mass, and how different intracellular mechanisms contribute to the execution of cell death in response to iron, is yet to be known in detail. This review sheds light on the dynamics of iron-dependent cell death in different cells within the tumor microenvironment and discusses how ferroptosis helps shape the cell-to-cell communication in different cancers. Furthermore, the review explores the consequences of ferroptosis in the establishment of tumors and the execution of their hallmark characteristics, along with the scope of ferroptosis-targeted therapies in the resolution of therapy-resistant cancers. As a whole, the review may be of significance in understanding the factual details of ferroptosis in the context of cancer in general and may show new directions in the potential application of this newly identified mode of cell death in next-generation cancer therapy.
Four Year Clinical Outcomes: Evaluating the Efficacy of Concomitant and Sequential Anthracycline-taxane Chemotherapy in Indian Breast Cancer Patients – A Regional Cancer Center Study
Authors: Mistry Tanuma , Nath Partha , Alam Neyaz , Nasare Vilas D. 
Published: February 2025

Abstract

Background:
Breast cancer (BC) continues to be one of the most significant challenges in global public health, contributing to approximately 11.6% of all cancer cases worldwide. While anthracycline-taxane-based regimens have been established as a first-line treatment option, the majority of safety and efficacy data for these therapies originate from the high-income countries, leaving gaps in understanding their impact in low- and middle-income settings.

Objective:
This study aims to report on clinical efficacy, toxicity, quality of life (QoL), and survival outcome of the following chemotherapeutic regimens: Anthracycline only (5-fluorouracil-epirubicin–cyclophosphamide), concomitant Docetaxel + Doxorubicin + Cyclophosphamide (TAC), and sequential Doxorubicin + Cyclophosphamide followed by Taxane (AC-T), among Indian BC patients in a high-volume tertiary cancer center.

Materials and Methods:
This study was conducted among histopathologically diagnosed 121 BC patients who received one of the aforementioned neo-adjuvant chemotherapies (NACTs) followed by surgery or surgery followed by adjuvant chemotherapy ± adjuvant radiation therapy ± hormone therapy. Clinical data, including patient demographics, tumor characteristics, treatment response, toxicity, QoL, and survival data, were collected and analyzed.

Results:
Stage II–III (52.89%, 38.01%) with Grade II (84.3%) tumor was more frequently diagnosed. NACT group was categorized: Complete (12.5%), partial (34.37%), and nonresponders (NRs) (53.13%). Few patients faced chemo-induced high-grade toxicities alopecia (79.33%), anemia (1.6%), diarrhea (1.6%), and constipation (1.6%). QoL among BC patients noticed to be decreased significantly (P < 0.05) with chemotherapy response during treatment but improved after the completion of chemotherapy (12th month). A significant association was found between progression-free survival (PFS) in NACT and disease-free survival (DFS) in NRs group (P < 0.0001). Although no significant difference was observed when three regimens were compared for PFS, overall survival, and DFS (P > 0.05). TAC regimen (hazard ratio [HR] 1.585; 95% confidence interval [CI]: 0.441–5.694) and AC-T regimen (HR 1.077; 95% CI: 0.320–3.260) showed higher HRs (P > 0.05).

Conclusions:
This study was robust and not significantly different in the subgroup. All three regimens showed varying tolerance with minimal high-grade toxicity and comparable clinical efficacy and safety. While the AC-T regimen did not significantly improve survival; however, a positive trend was observed, suggesting its potential as a preferred option for certain patient cohorts, aligning with findings from Western studies. These results support the evidence-based optimization of chemotherapy regimens for BC management in the resource-limited settings.
درجة إسهام الجامعات السعودية في تحقيق التنمية المستدامة في ضوء الشراكة المجتمعية
Authors: الدوسري عيسى 
Published: February 2025

هدفت هذه الدراسة إلى الكشفِ عن درجة إسهام الجامعات السعودية في تحقيق التنمية المستدامة من وجهة نظر أعضاء هيئة التدريس، والتعرفِ على أبرز مقومات نجاح الجامعات السعودية في تحقيق التنمية المستدامة، وتم اختيار عينة عشوائية طبقية من بعض الجامعات السعودية، بلغ عددها (627) عضو هيئة تدريس من (جامعة شقراء، وجامعة الحدود الشمالية، وجامعة الإمام عبدالرحمن بن فيصل)، وقد توصلت الدراسة لعدة نتائج، أهمها: أن درجة موافقة أفراد عينة الدراسة لإسهام الجامعات السعودية في تحقيق التنمية المستدامة في ضوء الشراكة المجتمعية كانت متوسطة في جميع مجالات أداة الدراسة، وأن درجة موافقتهم لأبرز مقومات نجاح الجامعات السعودية في تحقيق التنمية المستدامة جاءت مرتفعة، وقدمت الدراسة عدة توصيات، أهمها: ضرورة تخصيص الموازنات المالية وتوفير الإمكانيات المادية والبشرية اللازمة لدعم وتسهيل قيام الجامعات بأدوارها في تنمية المجتمع المحلي، وإقامة الندوات والبرامج التوعوية والتثقيفية لأفراد المجتمع الجامعي وأفراد المجتمع المحلي ومؤسساته حول أهمية الشراكة المجتمعية للجامعات ودورها في تنمية المجتمع.
الكلمات المفتاحية: الشراكة المجتمعية، تنمية المجتمع المحلي، التنمية المستدامة
The effectiveness of trunk training on Trunk Performance & trunk control in Patients With Stroke: A Systematic review.
Authors: Simran Jethani , Suvarna S ( PhD) Prof. Ganvir 
Published: February 2025

BACKGROUND: The trunk muscle weakness and the loss of proprioception concerning the affected side can interfere with balance, stability, and functional disability. Trunk control has been identified as an important early predictor of functional outcome after stroke.
OBJECTIVE: To explore the literature regarding the use of trunk training exercises (TTE) in patients with stroke to improve trunk performance and trunk control.
METHODS: PubMed/MEDLINE, Google Scholar, and CINHAL databases were searched with the key words Stroke and trunk Training Exercises according to MESH criteria and reference lists screened to identify randomized controlled trials (RCTs) of trunk training exercises in stroke survivors. Two reviewers independently screened references, selected relevant studies, extracted data, and assessed trial report quality.
RESULTS: A total of 09 studies with 328 participants met the inclusion criteria. Out of the 9 studies, 5 included both acute & subacute, 1 study included only acute & 3 only chronic patients with Stroke. Trunk training exercises, Core stability exercises and weight shifting exercises performed with either stable or unstable surfaces showed moderate evidence to improve trunk performance and Trunk Control in Patients with acute & subacute stroke.
CONCLUSION: Trunk Training Exercises performed on a stable surface have been used widely to improve Trunk control in patients with Stroke. However, its effect on functional tasks needs to be explored through well-designed research studies with specific outcome measures.
Prevalence study of hand arm vibration syndrome and its association with hand grip strength in farmers around Jalgaon district.
Authors: Siddhi Sanke , Jaywant Nagulkar , Priti Patil 
Published: February 2025

Aim- To find the Prevalence of hand arm vibration syndrome (HAVS) and its association with hand grip strength in farmers around Jalgaon district. Objectives- To find the prevalence of HAVS in farmers using Stockholm workshop scale and to assess hand grip strength in farmers having HAVS using Hand dynamometer. Methodology- A prevalence study was conducted among farmers. Farmers were selected according to inclusion criteria. The Stockholm workshop scale was used to check vascular and sensorineural symptoms in farmers, after diagnosing HAVS, the hand grip strength of the subjects was assessed by using hand dynamometer. Result- Data from 90 farmers was obtained and analyzed. Affected population of both vascular and sensorineural component, among which 18.88% population had mild symptoms and 13.33% of population had moderate symptoms. Among which mild (n=2) population and moderate (n=8) population had very poor grip strength (<40). Conclusion- The total prevalence of affected population having HAVS is 31%. there may be a risk of having more severe symptoms of HAVS in future which provides a better understanding of the impact and extend of HAVS in farmers.
Comparison of Blood Flow Restriction Training Versus Traditional Strengthening on Handgrip Strength and Forearm Girth in Young Adults.
Authors: Sakshi Uttamchandani , Chaitali Neve 
Published: February 2025

Background: Blood flow restriction, a form of low intensity resistance exercise that when applied on body it demonstrates physiological changes that give positive outcomes like increased muscle growth, oxygen delivery and utilization of maximal oxygen. The purpose of this study was to examine effects of 4-week Blood flow restriction training protocol on forearm girth on grip strength in young adults.
Methods: A comparative study was carried out in 80 normal individuals ( divided in two groups) after examining inclusion and exclusion criteria with pre assessment of forearm girth and grip strength of both right and left hand.
Results: Blood flow restriction training group has shown more significant results than traditional training group.
Conclusion: This study concludes that both the groups were effective post intervention. But BFRT has shown more significant results as compared to traditional training on handgrip strength and forearm girth.
Association Between Duration and Symptoms in Patients With Diabetic Neuropathy.
Authors: Kanchan Joshi , Maheshwari Harishchandre , Suvarna Ganvir 
Published: February 2025

Introduction: High blood sugar level leads to Diabetic Neuropathy.The average time gap between the onset of diabetes and its detection in an individual is 4 -7 years. . Methodology: It was a population based cross-sectional study conducted using purposive sampling method on 50 samples of patients who were diagnosed as Diabetes Mellitus and Diabetic Neuropathy according to MNSI and HbA1C, admitted in I.P.D and Neurophysiotherapy O.P.D at tertiary care hospital for duration of 1 year. Asymptomatic diabetic patients, patients with severe neurological, musculoskeletal or cardiac problems, non-co-operative patients and the patients with poor mental status were excluded from study. Ahmednagar Neuropathy Screening Instrument Scale (ANSI) was administered on the patients. Results: Data was analyzed by using ANOVA test which shows that mean value of total score of symptoms on ANSI for the duration of 0-5 years is 6.15 which goes on increasing as the duration increases and it is 36 for the duration of 30 years of Diabetic Neuropathy which reveals that as the duration increases, the severity of symptoms also goes on increasing. So the final result is; there is association between duration and symptoms in patients with Diabetic Neuropathy. Conclusion: Diabetic Neuropathy consumes more time to show its physical symptoms on patient’s i.e. longer the duration of having diabetic neuropathy more symptoms are appears in the patients. As the coefficient is significant, the present study concluded that there is association between duration and symptoms in patients with diabetic neuropathy.
Immediate effect of Positional release therapy vs Ischemic compression therapy for gastrocnemius latent trigger point to reduce pain and improve active ankle dorsiflexion in football players: A comparative study
Authors: Arshee Bagdadi , Mohd Junaid Shaikh , Sanat Kulkarni 
Published: February 2025

Background: Football is moderate contact sport. Correspondence to FIFA world cup survey, the injuries most frequently affected was lower extremity (65.4%). Maximum injured site was found to be the calf (29.62%). Latent MTP’s are those that are clinically dormant with regards to spontaneous pain and pains only on palpation. Ischemic Compression is the application of progressively strong, painful pressure on trigger point to eliminate the trigger point. On performing ischemic compression, tissue attains recovery by reperfusion thereby relieving transient blood flow occlusion. PRT is indirect and passive treatment also known as strain counter stain therapy which positions the muscle in position of comfort for a period (POC) for 90 seconds while maintaining a sustained manual pressure. Both techniques have been proven to improve pain and ROM
Methodology: 38 individuals of 18-30 years having latent trigger point in gastrocnemius were randomly divided between 2 groups included in the study and single intervention of PRT to group 1 and ICT to group 2 was given. Pain and Ankle Dorsiflexion was measured pre and post intervention using VAS and weight bearing lunge test respectively.
Results: A significant difference was found in both the groups, for pain VAS score pre intervention is 6.52 and post is 5.39 with p<0.05, ICT (p= 0.0003) for ankle dorsiflexion WBLT score PRT (p= 0.0019) ICT pre intervention is 14.91 and post is 15.73 with p<0.05. A non-significant difference was found between both the groups, for pain VAS score (p= 0.655) for ankle dorsiflexion WBLT score (p= 0.082)
Conclusion: There was no statistically significant difference between PRT and ICT and both treatments showed significant improvement in pain and ankle dorsiflexion equally.
Association between BMI and Quadricep strength on function, health related quality of life and progression of condition in a patient with osteoarthritis of knee joint: A cross-sectional study
Authors: Kruti Thakkar 
Published: February 2025

Background:
Knee OA is a leading cause of pain, disability, and reduced QoL globally, especially in aging. BMI is a critical risk factor for OA. Quadriceps strength plays a crucial role in joint stability and function, with weaker quadriceps associated with poorer outcomes in OA patients.
Methods:
A total of 200 patients with knee OA were recruited. BMI recorded physical examinations, Quadriceps strength measured using handheld dynamometer, and OA severity using the KL grading system. Functional ability through the WOMAC, and HRQoL using SF-36 questionnaire.
Results:
Higher BMI was significantly correlated with worse knee function, poorer HRQoL, and advanced OA progression. Quadriceps strength showed significant positive correlations with knee function and slower OA progression, but no significant correlation with HRQoL.
Conclusions:
The findings suggest that high BMI negatively impacts function, quality of life, and disease progression in knee OA patients, while stronger quadriceps are associated with better function and slower OA progression.
Keywords:
Osteoarthritis, BMI, Quadricep Strength, WOMAC, HRQoL
Миссионерская деятельность митрополита Евсевия (Никольского, 1860–1922 гг.): общая характеристика
Authors: Самохлиб С.О. 
Published: February 2025

В статье приводится краткий обзор жизнедеятельности митрополита Крутицкого Евсевия (Никольского). Период его архипастырского служения совпал с переломным этапом в истории Русской Православной Церкви и Российского государства. Последние годы своей жизни митрополит Евсевий провел в Москве. В 1922 г., после ареста Святейшего патриарха Тихона (Беллавина), формально руководил Церковью, исполняя возложенные на него обязанности. Этому высокому служению предшествовал более чем двадцатилетний период служения в отдаленных епархиях, нуждающихся в добрых и талантливых миссионерах. В данной статье рассматриваются основные вехи служения владыки Евсевия на Дальнем Востоке и его вклад в распространение в этом регионе православия.
The article provides a brief overview of the life of Metropolitan Eusebius of Krutitsky (Nikolsky). The period of his archpastoral ministry coincided with a turning point in the history of the Russian Orthodox Church and the Russian state. Metropolitan Eusebius spent the last years of his life in Moscow. In 1922, after the arrest of His Holiness Patriarch Tikhon (Bellavin), he formally led the Church, fulfilling the duties assigned to him. This high ministry was preceded by more than twenty years of service in remote dioceses in need of kind and talented missionaries. This article discusses the main milestones of the ministry of Vladyka Eusebius in the Far East and his contribution to the spread of Orthodoxy in this region.