bluuebunny/crossref_metadata_2025_split huggingface dataset:
“I Am Unhide-able”: Conditions of Visibility in The Poet X
Authors: Foote Rebecca 
Published: April 2024

Abstract
Within Latinx literary studies, young adult literature remains on the margins of scholarship. Yet if the overwhelming popularity of Elizabeth Acevedo’s award-winning novel-in-verse, The Poet X (2018), is any indication, then the genre of Latinx young adult literature offers important insights into contemporary Latinx literatures and cultures. This article argues that The Poet X leverages its multimodal qualities to deconstruct the hierarchies of knowledge that render Afro-Latinx subjects, especially young women, both invisible and hypervisible. As slam poetry allows Xiomara, the fifteen-year-old protagonist, to alter these conditions of visibility in her coming-of-age narrative, Acevedo’s book about the medium—a novel of page poems that are the textual source of performance poems housed online—also manifests social change, for Acevedo’s book has helped to shift Latinx young adult literature into a politics of inclusion and a register of empowerment. By centering a young, Dominican, Afro-Latina woman, The Poet X resists the homogenization of Latinidad by turning to slam poetry as a creative outlet of self-reclamation. Drawing from Diana Taylor’s The Archive and the Repertoire: Performing Cultural Memory in the Americas (2003), the article contends that the literary and performatic qualities of the poems in the text demonstrate why Latinx young adult literature is crucial to Latinx literary studies more broadly. Ultimately, Acevedo’s multimodal poetic project extends its account of Xiomara’s slam experience to uphold Afro-Latinx youth, and Afro-Latinx girls especially, as creators of worlds and makers of knowledge that disrupts traditional constructions of Latinidad.
The N-terminal domains of NLR immune receptors exhibit structural and functional similarities across divergent plant lineages
Authors: Chia Khong-Sam , Kourelis Jiorgos , Teulet Albin , Vickers Martin , Sakai Toshiyuki , Walker Joseph F , Schornack Sebastian , Kamoun Sophien , Carella Philip 
Published: April 2024

Abstract
Nucleotide-binding domain and leucine-rich repeat (NLR) proteins are a prominent class of intracellular immune receptors in plants. However, our understanding of plant NLR structure and function is limited to the evolutionarily young flowering plant clade. Here, we describe an extended spectrum of NLR diversity across divergent plant lineages and demonstrate the structural and functional similarities of N-terminal domains that trigger immune responses. We show that the broadly distributed coiled-coil (CC) and toll/interleukin-1 receptor (TIR) domain families of nonflowering plants retain immune-related functions through translineage activation of cell death in the angiosperm Nicotiana benthamiana. We further examined a CC subfamily specific to nonflowering lineages and uncovered an essential N-terminal MAEPL motif that is functionally comparable with motifs in resistosome-forming CC-NLRs. Consistent with a conserved role in immunity, the ectopic activation of CCMAEPL in the nonflowering liverwort Marchantia polymorpha led to profound growth inhibition, defense gene activation, and signatures of cell death. Moreover, comparative transcriptomic analyses of CCMAEPL activity delineated a common CC-mediated immune program shared across evolutionarily divergent nonflowering and flowering plants. Collectively, our findings highlight the ancestral nature of NLR-mediated immunity during plant evolution that dates its origin to at least ∼500 million years ago.
Predicting the Equity Premium with Combination Forecasts: A Reappraisal
Authors: Denk Sebastian , Löffler Gunter 
Published: April 2024

Abstract
This paper reappraises the usefulness of combining individual forecasts for predicting the U.S. equity premium. For comparison, we also consider penalized regression and dimension reduction approaches. We fail to find evidence of predictive ability in recent decades, regardless of the forecasting method used. Further analysis shows that an increase in the correlation of individual forecast errors is an important factor in the declining performance of combination forecasts.
Higher First 30-Day Dose of Buprenorphine for Opioid Use Disorder Treatment Is Associated With Decreased Mortality
Authors: Lei Feitong , Lofwall Michelle R. , McAninch Jana , Adatorwovor Reuben , Slade Emily , Freeman Patricia R. , Moga Daniela C. , Dasgupta Nabarun , Walsh Sharon L. , Vickers-Smith Rachel , Slavova Svetla 
Published: April 2024

ObjectiveBuprenorphine is a medication for opioid use disorder that reduces mortality. This study aims to investigate the less well-understood relationship between the dose in the early stages of treatment and the subsequent risk of death.MethodsWe used Kentucky prescription monitoring data to identify adult Kentucky residents initiating transmucosal buprenorphine medication for opioid use disorder (January 2017 to November 2019). Average daily buprenorphine dose for days covered in the first 30 days of treatment was categorized as ≤8 mg, >8 to ≤16 mg, and >16 mg. Patients were followed for 365 days after the first 30 days of buprenorphine treatment. Endpoints were opioid-involved overdose death and death from other causes. Causes and dates of death were obtained using Kentucky death certificate records. Associations were evaluated using multivariable Fine and Gray models adjusting for patient baseline characteristics.ResultsIn the cohort of 49,857 patients, there were 227 opioid-involved overdose deaths and 459 deaths from other causes. Compared with ≤8 mg, the adjusted subdistribution hazard ratio (aSHR) of opioid-involved overdose death decreased by 55% (aSHR, 0.45; 95% confidence interval [CI], 0.34–0.60) and 64% (aSHR, 0.36; 95% CI, 0.25–0.52) for patients receiving doses of >8 to ≤16 mg and >16 mg, respectively. The incidence of death from other causes was lower in patients receiving >8 to ≤16 mg (aSHR, 0.78; 95% CI, 0.62–0.98) and >16 mg (aSHR, 0.62; 95% CI, 0.47–0.80) versus ≤8 mg dose.ConclusionsHigher first 30-day buprenorphine doses were associated with reduced opioid-involved overdose death and death from other causes, supporting benefit of higher dosing in reducing mortality.
Is Using a Ring External Fixator in the Treatment of Congenital Pseudarthrosis of the Tibia Associated With Better Results or Using a Locking Plate?
Authors: Zargarbashi Ramin , Bagherpour Ali , Panjavi Behnam , Bagherpour Zarchi Masoud 
Published: April 2024

Background:
Congenital pseudarthrosis of the tibia (CPT) is a rare disease. CPT is often unilateral and occurs between the middle and distal third of the tibia. Concurrent involvement of the fibula is present in more than half of cases. histologic studies indicate the presence of fibrous hamartoma tissue and a sick periosteum, which leads to recalcitrant bone fracture and, eventually, pseudoarthrosis. Although there are various surgical techniques, we intend to compare the 2 methods of external fixation versus internal plating.

Methods:
Demographic data were collected from 26 patients with frank pseudoarthrosis. After exclusion criteria, patients were compared in groups A (12 patients) and B (11 patients). Resection of hamartoma and sclerotic bone, intramedullary rodding and autologous bone, and periosteal grafting were performed for all patients. In group A, we used a ring external fixator for compression and rotational stability, but in group B, a locking plate was used for these purposes.

Results:
Plating takes less time to use during surgery. In group A, the primary bony union was obtained in 67% of patients, while in group B, 82% of patients had a primary union. Meanwhile, the average time till the final union in group A was 6 months, while in group B, this time was 3.5 months. Positive union mass was obtained in 58% of the patients in group A and 82% of group B. In addition, plating prevented ankle valgus deformity in group B.

Conclusions:
Permanent intramedullary rodding is a surgical requirement for correction of deformity and refracture prevention, but additional stability can be achieved with the use of a ring external fixator or internal plate. Cross union and positive union mass are 2 important factors in the treatment of pseudoarthrosis; these results are achieved to a greater extent and in a shorter period of time using the plate.

Level of Evidence:
level IV – case series.
Prostate cancer burden in major BRICS countries, 1990–2019: findings from the 2019 global burden of disease study
Authors: Zhang Juan , Ma Juanjuan , Li Shuting , Ma Yan 
Published: April 2024

Background
This study assessed prostate cancer burden and trends in major BRICS countries (Brazil, Russia, India, China, and South Africa) from 1990 to 2019.

Methods
Utilizing Global Burden of Disease Study 2019 data, we calculated age-standardized rates for prostate cancer incidence, prevalence, mortality, and disability-adjusted life years (DALYs) with 95% uncertainty intervals (UIs). Joinpoint regression analysis determined the average annual percentage change (AAPC) for trend characterization.

Results
Prostate cancer ranked highest in China for incidence, prevalence, mortality, and DALYs. In 2019, Brazil had the highest age-standardized incidence rate (ASIR) [55.029 (95% UI: 47.744–81.831)] and age-standardized prevalence rate (ASPR) [372.511 (95% UI: 327.549–549.128)], while South Africa recorded the highest age-standardized mortality rate (ASMR) [42.241 (95% UI: 32.146–47.933)], and age-standardized DALY rate (ASDR) [666.085 (95% UI: 522.626–764.612)]. ASIR and ASPR increased significantly over three decades (AAPC > 0), with varying ASMR and ASDR trends.

Conclusion
Prostate cancer poses a significant public health challenge. While incidence and prevalence rise, mortality declines in China, India, and Brazil. Tailored health policies are crucial to address diverse disease burden characteristics.
Cancer-Specific Mortality Odds Ratios in the Food, Accommodation, and Beverage Activities in Italy
Authors: Gariazzo Claudio , Massari Stefania , Consonni Dario , Marchetti Maria Rosaria , Marinaccio Alessandro 
Published: April 2024

ObjectivesThis study investigated cancer-specific mortality risks of workers employed in food, accommodation and beverage (FAB) activities.Methods:We performed a case-control study based on countrywide mortality and National Social Insurance data. Adjusted cancer-specific mortality odds ratios (MOR) were calculated. We modeled occupational exposure as “ever/never been employed” in FAB activities, using other sectors as reference. Analysis was performed by gender, length of employment and year of smoke banning.Results:About 20,000 cancer deaths in FAB were analyzed. Working in restaurants was positively associated with cancer of lung (MOR = 1.24), bladder (MOR = 1.24), pharynx, and larynx. Accommodation was associated with cancer of pharynx (MOR = 1.46), while beverage with cancer of liver (MOR = 1.22). Gender, length of employment and smoke banning were found effective in modifying some risks.Conclusions:Workers in FAB sectors were at risk for several cancers.
Splenic abscess presenting as pneumonia with pleural effusion initially: A rare case in a 2-year-old girl: A case report
Authors: Chen Siao-Rong , Jiang Chuen-Bin 
Published: April 2024

Rationale:
Splenic abscess is rarely discovered during the toddler period. Although most of the cases are typically marked by fever, abdominal pain, and vomiting, some of them may suffer life-threatening situations. This study aimed to explore how early detection can prevent serious disease complications.

Patient concerns:
A 2-year-old child with persisted fever and shortness of breathing was admitted. Physical examination was decreasing breathing sound on the left side. We gave empirical antibiotics use with chest tube drainage for 2 days in vain. No fever dropping and persistent left upper abdominal pain were noted. A huge mass was found on left spleen incidentally during abdominal ultrasound screen.

Diagnosis:
Huge splenic abscess.

Intervention:
High-resolution ultrasound and abdominal computer tomogram were conducted to confirm the diagnosis. Percutaneous drainage under computer tomography-guided with antibiotic use was smoothly. No obvious adverse effects were noted during the treatment course. Rapid clinical improvement with decreasing size was observed by ultrasound 10 days after the treatment and fever subsided.

Outcomes:
A period of 3-month follow-up revealed no evidence of recurrence of abscess.

Lessons:
Early diagnosis and intervention are mandatory for splenic abscess to prevent possible ominous consequences. The case study has shown that computer tomography-guided percutaneous drainage, along with appropriate antibiotic therapy, can significantly impact solitary unilocular splenic abscesses, even if they are large. This approach demonstrates the potential to effectively manage splenic abscesses and avoid the need for more invasive procedures such as splenectomy.
Clinicopathologic and Molecular Characterization of Xanthomatous Giant Cell Renal Cell Carcinomas
Authors: Xu Yuemei , Zhang Xue , Xia Qiuyuan , Zhou Yuning , Wang Xiaotong , Fang Ru , Wang Ya , Tong Qi , Chen Jieyu , Shi Jiong , Fu Yao , Rao Qiu 
Published: April 2024

A recent study described a rare subtype of tuberous sclerosis complex (TSC)-mutated renal cell carcinoma primarily characterized by Xanthomatous giant cell morphology. Only 2 cases in young individuals have been reported so far, making the correct diagnosis challenging from a pathological perspective. It remains unknown whether this tumor represents an independent subtype or belongs to otherTSC-mutated tumors. We conducted a clinicopathologic evaluation and immunohistochemical profiling of 5 cases of Xanthomatous Giant Cell Renal Cell Carcinoma (XGC RCC) with confirmedTSC2mutations through targeted DNA sequencing. In addition, we analyzed transcriptomic profiles using RNA-seq for the following samples: XGC RCC, Low-grade Oncocytic tumors (LOT), High-grade Oncocytic tumors/Eosinophilic Vacuolar Tumors (HOT/EVT), Eosinophilic Solid and Cystic Renal Cell Carcinomas (ESC RCC), Chromophobe cell Renal Cell Carcinomas (ChRCC), Renal Oncocytomas (RO), clear cell Renal Cell Carcinomas (ccRCC), and normal renal tissues. There were 2 female and 3 male patients, aged 22 to 58 years, who underwent radical nephrectomy for tumor removal. The tumor sizes ranged from 4.7 to 9.5 cm in diameter. These tumors exhibited ill-defined boundaries, showed an expansive growth pattern, and featured distinctive tumor giant cells with abundant eosinophilic to Xanthomatous cytoplasm and prominent nucleoli. All tumors had low Ki-67 proliferation indices (<1%) and demonstrated immune reactivity for CD10, PAX8, CK20, CathepsinK, and GPNMB. Next-generation sequencing confirmedTSC2mutations in all cases. RNA sequencing-based clustering indicated a close similarity between the tumor and ESC RCC. One patient (1/5) died of an accident 63 months later, while the remaining patients (4/5) were alive without tumor recurrences or metastases at the time of analysis, with a mean follow-up duration of 43.4 months. Our research supports the concept that Xanthomatous giant cell renal cell carcinoma (XGC RCC) shares clinicopathological and molecular characteristics with ESC RCC and shows a relatively positive prognosis, providing further support for a close morphologic spectrum between the two. We propose considering XGC RCC as a distinct subtype of ESC RCC.
Comparison of law enforcement officer– versus emergency medical services–placed tourniquets
Authors: Shukla Dhara , Shapiro Geoff , Smith E. Reed , Sarani Babak 
Published: April 2024

INTRODUCTIONTourniquet use for hemorrhage control is a core skill for many law enforcement officers (LEOs) and all emergency medical services (EMS) providers. However, LEO tourniquet training is not as intensive as EMS. Overuse of tourniquet can result in overtriage. We hypothesize that LEOs are more liberal than EMS with tourniquet placement.METHODSA 7-year retrospective, single-center study of adult patients who had a tourniquet placed in the field was conducted. Data were stratified by provider who placed the tourniquet. Patient demographics, body location where the tourniquet was placed, hospital location where the tourniquet was removed, incidence of recurrent bleeding and need for operative control of bleeding, and name of injured vessel were recorded. Data were analyzed using Student'stand χ2tests.RESULTSA total of 192 patients had 197 tourniquets placed (LEO, 77 [40%]; EMS, 120 [63%]). Most tourniquets were placed on the thigh. There was no difference in body mass index, but the EMS cohort had a higher Injury Severity Score (9.4 vs. 6.5,p= 0.03) and extremity Abbreviated Injury Scale severity score (2.4 vs. 1.9,p= 0.007). The LEO-placed tourniquets were more commonly removed in the trauma bay (83% vs. 73%,p= 0.03). The EMS-placed tourniquets were more likely to require operative control of bleeding (23% vs. 6%,p= 0.003). There were no complications related to tourniquet use in either arm.CONCLUSIONLaw enforcement officers are more likely than EMS to place tourniquets without injury to a named vessel or the presence of severe bleeding. Law enforcement officers need better training to determine when a tourniquet is needed. Emergency medical services should be allowed to remove tourniquet if appropriate. Studies on the impact of overtriage based on tourniquet use are needed.LEVEL OF EVIDENCETherapeutic/Care Management; Level III.
Fabaceae and Cerrado savanna: Two descriptors of Brazilian extrafloral nectary plants
Authors: Barbosa Vanessa Dayane da Costa , Bächtold Alexandra , Del-Claro Kleber , Silva Estevao Alves da 
Published: April 2024

AbstractExtrafloral nectaries (EFNs) have been described in almost 4000 plant species, but there are several gaps in our knowledge of their occurrence and distribution. Here, we investigated the geographical distribution and richness of EFN–plants in Brazilian biomes (Cerrado, Atlantic Forest, Caatinga, Amazon, Pantanal, and Pampa). Data were extracted from 170 papers, and our analysis included only EFN–plants that interacted with ants. A total of 224 EFN–plant species in 115 genera and 48 families were registered in five biomes: Cerrado, Atlantic Forest, Caatinga, Pampa, and the Amazon. The Cerrado was evaluated in 64% of all publications, had the highest richness (90 species) and the most exclusive flora compared to the other biomes. In addition, the most studied species belonged to the Cerrado flora (e.g.,Caryocar brasiliense). Fabaceae was the most speciose family, with 76 species, being dominant in all biomes and greatly surpassing other families. Only Fabaceae and Euphorbiaceae were found in all biomes, and in general, each biome had its own flora, as only 18 (of 224) plants were found in more than one biome. In a network analysis,Qualea grandilfloraandPlathymenia reticulatawere relatively more important than other species, as they connected biomes and increased the cohesion of the community. Our study shows that our understanding of EFN–plants is limited because the Fabaceae and Cerrado were overrepresented. A detailed record of species occurrence and distribution could be a valuable tool for studying the biodiversity of EFN–plants and their potential mutualistic interactions.
Association of caffeine consumption with memory deficits and cerebrospinal fluid biomarkers in Mild Cognitive Impairment and Alzheimer’s Disease: a BALTAZAR cohort study
Authors: Blum David , Cailliau Emeline , Béhal Hélène , Vidal Jean-Sébastien , Delaby Constance , Buée Luc , Allinquant Bernadette , Gabelle Audrey , Bombois Stéphanie , Lehmann Sylvain , Schraen-Maschke Susanna , Hanon Olivier 
Published: April 2024

STRUCTURED ABSTRACTINTRODUCTIONWe investigated the link between habitual caffeine intake with memory deficits and CSF AD biomarkers in Mild cognitive impairment (MCI) and Alzheimer’s Disease (AD) patients.METHODSMCI (N=147) and AD (N=116) patients of the BALTAZAR longitudinal cohort reported their caffeine intake using a dedicated survey and were followed-up for 3 years. Associations of caffeine consumption with cognition, MMSE decline and CSF biomarkers (Tau, pTau181, Aβ1-42, Aβ1-40) were analyzed using logistic and ANCOVA models.RESULTSAdjusted on APOEε4, age, sex, education level and tobacco, lower caffeine consumption was associated with higher risk to be amnestic (OR: 2.49 [95%CI: 1.13 to 5.46]; p=0.023) and lower CSF Aβ1-42(p=0.047), Aβ1-42/ Aβ1-40(p=0.040) and Aβ1-42/pTau (p=0.020) in the whole cohort and a faster MMSE decline in amnestic MCI (p=0.024).DISCUSSIONData supports the beneficial effect of caffeine consumption to memory decline and CSF amyloid markers in MCI and AD patients.
Chloride Homeostasis Regulates cGAS-STING Signaling
Authors: Morse Jared , Wang Danna , Mei Serena , Whitham Danielle , Hladun Colby , Darie Costel C. , Sintim Herman O. , Wang Modi , Leung KaHo 
Published: April 2024

SummaryThe cGAS–STING signaling pathway has emerged as a key mediator of inflammation. However, the roles of chloride homeostasis on this pathway are unclear. Here, we uncovered a correlation between chloride homeostasis and cGAS-STING signaling. We found that dysregulation of chloride homeostasis attenuates cGAS-STING signaling in a lysosome-independent manner. Treating immune cells with chloride channel inhibitors attenuated 2’3’-cGAMP production by cGAS and also suppressed STING polymerization, leading to reduced cytokine production. We also demonstrate that non-selective chloride channel blockers can suppress the NPC1 deficiency-induced, hyper-activated STING signaling in skin fibroblasts derived from Niemann Pick disease type C (NPC) patients. Our findings reveal that chloride homeostasis majorly affects cGAS-STING pathway and suggest a provocative strategy to dampen STING-mediated inflammation via targeting chloride channels.HighlightsChloride dysregulation attenuates cGAS-STING signaling in a lysosome-independent manner.Chloride dysregulation attenuates intracellular 2’3’-cGAMP production.Chloride dysregulation inhibits STING polymerization and STING-to-IRF3 signaling.Chloride channel blockers suppress NPC1 deficiency-induced, hyper-activated STING signaling.Graphical abstract
Toward green production practices: empirical evidence from Thai manufacturers' technical efficiency
Authors: Amornkitvikai Yot , O'Brien Martin , Bhula-or Ruttiya 
Published: April 2024

PurposeThe development of green manufacturing has become essential to achieve sustainable development and modernize the nation’s manufacturing and production capacity without increasing nonrenewable resource consumption and pollution. This study investigates the effect of green industrial practices on technical efficiency for Thai manufacturers.Design/methodology/approachThe study uses stochastic frontier analysis (SFA) to estimate the stochastic frontier production function (SFPF) and inefficiency effects model, as pioneered by Battese and Coelli (1995).FindingsThis study shows that, on average, Thai manufacturing firms have experienced declining returns-to-scale production and relatively low technical efficiency. However, it is estimated that Thai manufacturing firms with a green commitment obtained the highest technical efficiency, followed by those with green activity, green systems and green culture levels, compared to those without any commitment to green manufacturing practices. Finally, internationalization and skill development can significantly improve technical efficiency.Practical implicationsGreen industry policy mixes will be vital for driving structural reforms toward a more environmentally friendly and sustainable economic system. Furthermore, circular economy processes can promote firms' production efficiency and resource use.Originality/valueTo the best of the authors' knowledge, this study is the first to investigate the effect of green industry practices on the technical efficiency of Thai manufacturing enterprises. This study also encompasses analyses of the roles of internationalization, innovation and skill development.