bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anemia in celiac disease is multifactorial in etiology
Authors: Harper Jason W. , Holleran Stephen F. , Ramakrishnan Rajasehkar , Bhagat Govind , Green Peter H.R. 
Published: July 2007

AbstractAnemia in celiac disease (CD) has been attributed to nutritional deficiencies; however, the clinical manifestations of CD have changed with nongastrointestinal presentations predominating. We collected hematologic parameters from a cohort of patients seen at a tertiary care center for CD to assess the characteristics of anemia in this population. Hematological parameters measured ≤3 months of diagnosis and degree of villous atrophy from 405 patients diagnosed >1995 was analyzed. Ferritin levels were compared with population controls (NHANES III). Iron deficiency was common, occurring in 33% of men and 19% of women (P < 0.001). Folate deficiency was seen in ∼12% of the total sample and B12 deficiency in ∼5%. Anemia was present in ∼20% of the cohort. Among the anemic patients, ferritin was less than the 10th percentile in 45%, between the 10th and 50th percentile in 39% and greater than the 50th percentile in 13%. Ferritin > 50th percentile was more common in anemic men (24%) than in anemic women (9%; P > 0.20). Macrocytic anemia with concurrent B12 or folate deficiency was rare (3%). Elevated ESR was observed in patients with ferritin < 10th percentile and >50th. A gluten‐free diet resulted in increased serum ferritin in iron‐deficient patients, and decreased ferritin levels in those with high ferritin (r2 = 0.46, P < 0.001). Although anemia is still a common presentation of celiac disease, nutritional deficiencies alone do not explain this phenomenon in all cases; inflammation appears to contribute as evidenced by the presence of anemia of chronic disease in some individuals. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.
The natural histories of bone dysplasias in adults—Vignettes, fables and just‐so stories
Authors: Pauli Richard M. 
Published: July 2007

AbstractThe bone dysplasias are a heterogeneous group of disorders arising from intrinsic abnormality of bone and cartilage growth and function. All are genetic. Most result in extreme small stature (dwarfism). Historically, emphasis was primarily on diagnostic identification of specific disorders in infants (including differentiating lethal and non‐lethal forms), and on the clinical history to be anticipated in infants and children with each of these specific processes. Even in children there is exceedingly limited information of quality and virtually no controlled studies of the effects of intervention. For the most part, information about affected adults is even less complete and even less rigorous. Presented here are a series of examples of medical and adaptive issues in adults affected by one or another of the genetic skeletal dysplasias. Topics discussed include: approach to adults with no specific diagnosis; medical issues that cross diagnostic boundaries (osteoarthritis in the “E” disorders, obstructive apnea, issues in pregnancy in women with dwarfing disorders, activities of daily living, and quality of life assessments); diagnosis‐specific problems of adulthood (spinal stenosis in achondroplasia, hearing loss in osteogenesis imperfecta, and malignancy risk in multiple exostoses); adult problems that must be addressed in childhood in order to be prevented (achondroplasia and kyphosis, and cervical spine abnormalities in Morquio syndrome); survival conundrums (why some live unexpectedly and others die unexpectedly). Emphasis is placed on the difficulties intrinsic to trying to learn about needs and expectations in generally rare genetic processes. © 2007 Wiley‐Liss, Inc.
Healthcare transition in persons with intellectual disabilities: General issues, the Maastricht model, and Prader–Willi syndrome
Authors: Schrander‐Stumpel Constance T.R.M. , Sinnema Margje , van den Hout Lieke , Maaskant Marian A. , van Schrojenstein Lantman‐de Valk Henny M.J. , Wagemans Annemieke , Schrander Jaap J.P. , Curfs Leopold M.G. 
Published: July 2007

AbstractIn current healthcare, transitional healthcare is a very important and timely issue. Thanks to the major advances made in medical care and technology, many children with childhood onset diseases and/or genetic syndromes survive to adulthood. These children are at risk of not being provided with adequate healthcare as they reach adulthood. Healthcare transition is an essential part of healthcare provision, referred to as the shift from one type of healthcare to another. In Maastricht, we developed a transition/out clinic led by a medical doctor specialized in persons with intellectual disability (ID), together with a clinical geneticist. We aim to coordinate healthcare issues based on guidelines if available. Also questions concerning living, daily activities, relations, sexuality, and sterilization can be discussed. The aging process of persons with ID has been a topic of interest in recent years. Little is known about the aging process of people with specific syndromes, except for persons with Down syndrome. We present some data of a recent questionnaire study in persons with Prader–Willi syndrome. In only 50% in persons with a clinical diagnosis genetic test results could be reported. The majority of persons were obese. Diabetes mellitus, hypertension, skin problems, sleep apnea, and hormonal problems like osteoporosis and hypothyroidism were common. Psychiatric problems were frequent, especially in the persons with uniparental disomy. Osteoporosis and sleep apnoea seem to be underestimated. Further longitudinal research is necessary for a better understanding of the aging process in PWS. © 2007 Wiley‐Liss, Inc.
Radical scavenging capacity of lignin and its effect on processing stabilization of virgin and recycled polypropylene
Authors: Gregorova A. , Košíková B. , Staško A. 
Published: July 2007

AbstractThe radical scavenging capacity of lignin was determined using spectrophotometric method by means of scavenging of the free radical 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH•) and compared with that of synthetic antioxidant Irganox 1010. Lignin reacted progressively with the DPPH• reaching a steady state in 6 h, showing high antiradical activity with a stochiometry of 5.5 reduced DPPH• molecules. Irganox 1010 showed lower antiradical activity reaching a steady state with DPPH• after 13 h. Moreover, stabilization efficiency of lignin has been investigated in virgin and recycled polypropylene. The stabilization effect of lignin was evaluated by melt volume rate (MVR). The efficiency of lignin as processing stabilizer in both series polypropylene samples was compared with that of synthetic antioxidant Irganox 1010. The presence and behavior of free radicals in the lignin/polypropylene composites formed during processing was determined by electron paramagnetic resonance (EPR). It was observed that used lignin sample could stabilise both virgin and recycled polypropylene. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2007
How is science cited on the Web? A classification of google unique Web citations
Authors: Kousha Kayvan , Thelwall Mike 
Published: July 2007

AbstractAlthough the analysis of citations in the scholarly literature is now an established and relatively well understood part of information science, not enough is known about citations that can be found on the Web. In particular, are there new Web types, and if so, are these trivial or potentially useful for studying or evaluating research communication? We sought evidence based upon a sample of 1,577 Web citations of the URLs or titles of research articles in 64 open‐access journals from biology, physics, chemistry, and computing. Only 25% represented intellectual impact, from references of Web documents (23%) and other informal scholarly sources (2%). Many of the Web/URL citations were created for general or subject‐specific navigation (45%) or for self‐publicity (22%). Additional analyses revealed significant disciplinary differences in the types of Google unique Web/URL citations as well as some characteristics of scientific open‐access publishing on the Web. We conclude that the Web provides access to a new and different type of citation information, one that may therefore enable us to measure different aspects of research, and the research process in particular; but to obtain good information, the different types should be separated.
Affibody‐mediated transferrin depletion for proteomics applications
Authors: Grönwall Caroline , Sjöberg Anna , Ramström Margareta , Höidén‐Guthenberg Ingmarie , Hober Sophia , Jonasson Per , Ståhl Stefan 
Published: July 2007

AbstractAn Affibody® (Affibody) ligand with specific binding to human transferrin was selected by phage display technology from a combinatorial protein library based on the staphylococcal protein A (SpA)‐derived Z domain. Strong and selective binding of the selected Affibody ligand to transferrin was demonstrated using biosensor technology and dot blot analysis. Impressive specificity was demonstrated as transferrin was the only protein recovered by affinity chromatography from human plasma. Efficient Affibody‐mediated capture of transferrin, combined with IgG‐ and HSA‐depletion, was demonstrated for human plasma and cerebrospinal fluid (CSF). For plasma, 85% of the total transferrin content in the samples was depleted after only two cycles of transferrin removal, and for CSF, 78% efficiency was obtained in single‐step depletion. These results clearly suggest a potential for the development of Affibody‐based resins for the removal of abundant proteins in proteomics analyses.
Future societal issues in industrial biotechnology
Authors: Schuurbiers Daan , Osseweijer Patricia , Kinderlerer Julian 
Published: July 2007

AbstractThree international stakeholder meetings were organized by the Netherlands‐based “Kluyver Center for Genomics of Industrial Fermentation” with the objective to identify the future societal issues in the field of industrial biotechnology and to develop a coordinated strategy for public dialogue. The meetings resulted in five unanimous recommendations: (i) that science, industry and the European Commission in conjunction with other stakeholders create a comprehensive roadmap towards a bio‐based economy; (ii) that the European Commission initiate a series of round‐table meetings to further articulate the views, interests and responsibilities of the relevant stakeholders and to define policy; (iii) that the development of new innovative communication activities is stimulated to increase public engagement and to discuss the ways that we do or do not want technologies to shape our common future; (iv) that further social studies are undertaken on public attitudes and behaviors to the bio‐based economy and that novel methods are developed to assess public views of future technological developments; and (v) that the concept of sustainability is further operationalized and taken as a core value driving research and development and policy making.
Improvement in extraction and catalytic activity of Mucor javanicus lipase by modification of AOT reverse micelle
Authors: Talukder Mahabubur Rahman , Susanto Diana , Feng Gao , Wu Jinchuan , Choi Won Jae , Chow Yvonne 
Published: July 2007

AbstractReverse micelles are formed in apolar solvents by spontaneous aggregation of surfactants. Surfactant sodium bis (2‐ethylhexyl) sulfosuccinate (AOT) is most often used for the reverse micellar extraction of enzymes. However, the inactivation of enzyme due to strong interaction with AOT molecules is a severe problem. To overcome this problem, the AOT/water/isooctane reverse micellar system was modified by adding short chain polyethylene glycol 400 (PEG 400). The modified AOT reverse micellar system was used to extract Mucor javanicus lipase from the aqueous phase to the reverse micellar phase. The extraction efficiency (E) increased with the increase in PEG 400 addition and the maximum E in PEG 400 modified system was twofold higher than that in the PEG 400‐free system. Upon addition of PEG 400, the water activity (aw) of aqueous phase decreased, whereas aw of reverse micellar phase increased. The circular dichroism spectroscopy analysis revealed that PEG 400 changes the secondary and tertiary structure of lipase. The maximum specific activity of lipase extracted in PEG 400‐modified reverse micellar system was threefold higher than that in the PEG‐free system.
Understanding Ribonucleotide Reductase Inactivation by Gemcitabine
Authors: Cerqueira Nuno M. F. S. A. , Fernandes Pedro A. , Ramos Maria J. 
Published: July 2007

AbstractThis paper focuses on the inhibition of ribonucleotide reductase (RNR) by gemcitabine, 2′,2′‐difluoro‐2′‐deoxycytidine (dFdC), a deoxycytidine analogue that is a very active drug against solid tumors and is currently commercialized as gemzar. RNR inactivation is reductant‐dependent and occurs in a very different way from that of other known substrate analogues. In the presence of reductants monomer R1 of RNR is inhibited, whereas in the absence of reductants the radical is lost and monomer R2 is inhibited. As inside the cell reductants are available, it is likely that R1 inactivation is the most favorable mechanism responsible for drug cytotoxicity. This inhibition pathway has been unknown to date, but we have conducted a theoretical study that has led us to the first proposal of a mechanism for RNR inhibition by dFdC in the presence of reductants.
Kinetic and Thermochemical Study of the Antioxidant Activity of Sulfur‐Containing Analogues of Vitamin E
Authors: Amorati Riccardo , Cavalli Andrea , Fumo Maria Grazia , Masetti Matteo , Menichetti Stefano , Pagliuca Chiara , Pedulli Gian Franco , Viglianisi Caterina 
Published: July 2007

AbstractSulfur‐containing analogues of vitamin E (thiachromanols), either linked or not to a catechol moiety, were synthesized and their hydrogen‐atom donating ability evaluated. The determination of the OH bond dissociation enthalpy (BDE) of the α‐tocopherol analogue 4 by the electron paramagnetic resonance (EPR) equilibration technique provided a value of 78.9 kcal mol−1, that is, approximately 1.8 kcal mol−1 higher than that of α‐tocopherol. The kinetic rate constants for the reaction with peroxyl radicals (kinh), measured by inhibited autoxidation studies, showed that thiachromanols react 2.5 times slower than the corresponding tocopherols, in agreement with the higher BDE value. This behavior was explained, on the basis of crystallographic analyses and DFT calculations, in terms of a change in the molecular geometry caused by insertion of a sulfur atom into the framework of vitamin E. This behavior implies a greater deviation of the condensed ring from coplanarity with the aromatic ring, thus giving rise to a decrease in the conjugative stabilization of the phenoxyl radical and consequently to an increase in the OH bond strength. Although less reactive than tocopherols, thiachromanols may, however, act as bimodal antioxidants as a result of the hydroperoxide decomposing ability of the sulfur atom.
Is This a Chemical Bond? A Theoretical Study of Ng2@C60(Ng=He, Ne, Ar, Kr, Xe)
Authors: Krapp Andreas , Frenking Gernot 
Published: July 2007

AbstractQuantum‐chemical calculations using DFT (BP86) and ab initio methods (MP2, SCS‐MP2) have been carried out for the endohedral fullerenes Ng2@C60(Ng=He–Xe). The nature of the interactions has been analyzed with charge‐ and energy‐partitioning methods and with the topological analysis of the electron density (Atoms‐in‐Molecules (AIM)). The calculations predict that the equilibrium geometries of Ng2@C60haveD3dsymmetry when Ng=Ne, Ar, Kr, while the energy‐minimum structure of Xe2@C60hasD5dsymmetry. The precession movement of He2in He2@C60has practically no barrier. The NgNg distances in Ng2@C60are much shorter than in free Ng2. All compounds Ng2@C60are thermodynamically unstable towards loss of the noble gas atoms. The heavier species Ar2@C60, Kr2@C60, and Xe2@C60are high energy compounds which are at the BSSE corrected SCS‐MP2/TZVPP level in the range 96.7–305.5 kcal mol−1less stable than free C60 + 2 Ng. The AIM method reveals that there is always an NgNg bond path in Ng2@C60. There are six NgC bond paths in (D3d) Ar2@C60, Kr2@C60, and Xe2@C60, whereas the lighterD3dhomologues He2@C60and Ne2@C60have only three NgC2paths. The calculated charge distribution and the orbital analysis clearly show that the bonding situation in Xe2@C60significantly differs from those of the lighter homologues. The atomic partial charge of the [Xe2] moiety is +1.06, whereas the charges of the lighter dimers [Ng2] are close to zero. The a2uHOMO of (D3d) Xe2@C60in the1A1gstate shows a large mixing of the highest lying occupied σ* orbital of [Xe2] and the orbitals of the C60cage. There is only a small gap between the a2uHOMO of Xe2@C60and the euLUMO and the a2uLUMO+1. The calculations show that there are several triplet states which are close in energy to each other and to the1A1gstate. The bonding analysis suggests that the interacting species in Xe2@C60are the charged species Xe2q+and C60q−, where 1<q<2. The calculated XeXe distance in the endohedral fullerene (2.494 Å) is even shorter than the calculated value for free Xe22+(2.746 Å). Thus, the XeC and XeXe interactions in Xe2@C60should be considered as genuine chemical bonds which are enforced by the compression energy. The NgNg and NgC interactions in the lighter homologues Ar2@C60and Kr2@C60may also be considered as chemical bonds because the theoretically predicted properties of the endohedral fullerenes are significantly different from the free C60and noble gas atoms. According to the bonding analysis, He2@C60and Ne2@C60are weakly bonded van der Waals complexes.
Interaction of Triatomic Germanium with Lithium Atoms: Electronic Structure and Stability of Ge3Lin Clusters
Authors: Gopakumar G. , Lievens Peter , Nguyen Minh Tho 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Crystal Structures of Ln5Au2X Ternary Compounds (Ln: Gd, Tb, Dy, Ho, Er; X: Sb, Bi)
Authors: Verbovytsky Yu. , Latka K. 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Crystal Structure Analysis of Scheelite and Zircon Type Thorium Germanates: A Neutron Diffraction Study.
Authors: Achary S. N. , Patwe S. J. , Krishna P. S. R. , Sindhe A. B. , Tyagi A. K. 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Pressure Response of an Organic—Inorganic Perovskite: Methylammonium Lead Bromide.
Authors: Swainson I. P. , Tucker M. G. , Wilson D. J. , Winkler B. , Milman V. 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structural Characterization of Molybdenum(V) Species in Aqueous HCl Solutions.
Authors: Jalilehvand Farideh , Mah Vicky , Leung Bonnie O. , Ross Daniel , Parvez Masood , Aroca Ricardo F. 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Luminescence and Energy Transfer in K3GdF6:Pr3+.
Authors: Gusowski M. A. , Dominiak‐Dzik G. , Solarz P. , Lisiecki R. , Ryba‐Romanowski W. 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structural Analysis and 57Fe Moessbauer Spectrometry of Zr6FeSn2 and Related Compounds.
Authors: Costa B. F. O. , Greneche J. M. , Fruchart D. , Alberto H. V. , Skryabina N. E. , Romaka L. P. , Stadnyk Yu. V. 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
BaFe3.39(5)Ru2.61(5)O11 and BaCo1.85(6)Ru4.15(6)O11. Preparation, Crystal Structures, and Magnetic and Transport Properties of Quaternary Transition Metal Oxoruthenates.
Authors: Schuepp‐Niewa Barbara , Shlyk Larisa , Kryukov Sergej , De Long Lance E. , Niewa Rainer 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Aziridine‐Modified Amino Alcohols as Efficient Modular Catalysts for Highly Enantioselective Alkenylzinc Additions to Aldehydes.
Authors: Braga Antonio L. , Paixao Marcio W. , Westermann Bernhard , Schneider Paulo H. , Wessjohann Ludger A. 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Hydrogenation of Ethyl Pyruvate Using Layered Double Hydroxide Supported Nano Noble Metal Catalysts.
Authors: Kantam Mannepalli Lakshmi , Kumar Karasala Vijaya , Sreedhar Bojja 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Intermolecular Addition Reaction to Alkenes of Acylmolybdenum Complexes Generated by Oxidative Addition of Aryl or Alkenyl Halides with Molybdenum(0) Carbonyl Complexes.
Authors: Sangu Kenichiro , Watanabe Toru , Takaya Jun , Iwasawa Nobuharu 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Organic Lewis Acid Assisted Elimination: ortho Esters as Surrogates for Ketene Acetals.
Authors: Jahangiri Saba , Liepa Andris J. 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Convenient One‐Pot Protocol for an Exclusive Synthesis of 4‐Cyano/ethoxycarbonyl‐2,2‐dimethyl‐2H‐chromene and/or 3‐Cyano/ethoxycarbonyl‐2‐isopropyl‐benzo[b]furan from a Single Oxo‐ylide.
Authors: Rao V. V. V. N. S. Rama , Yadla R. , Rao P. Shanthan 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Meyer—Schuster Rearrangement of Ethoxyalkynyl Carbinols.
Authors: Lopez Susana S. , Engel Douglas A. , Dudley Gregory B. 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Simple One‐Pot Procedure for the Direct Conversion of Alcohols into Azides Using TsIm.
Authors: Soltani Rad Mohammad Navid , Behrouz Somayeh , Khalafi‐Nezhad Ali 
Published: July 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.