bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mushroom elbaite from the Kat Chay mine, Momeik, near Mogok, Myanmar: I. Crystal chemistry by SREF, EMPA, MAS NMR and Mössbauer spectroscopy
Authors: Lussier A. J. , Aguiar P. M. , Michaelis V. K. , Kroeker S. , Herwig S. , Abdu Y. , Hawthorne F. C. 
Published: November 2008

AbstractTourmaline from the Kat Chay mine, Momeik, near Mogok, Shan state, Myanmar, shows a variety of habits that resemble mushrooms, and it is commonly referred to as ‘mushroom tourmaline'. The structure of nine single crystals of elbaite, ranging in colour from pink to white to black and purple, extracted from two samples of mushroom tourmaline from Mogok, have been refined (SREF) to R indices of ~2.5% using graphite-monochromated Mo-Kα X-radiation. 11B and 27Al Magic Angle Spinning Nuclear Magnetic Resonance spectroscopy shows the presence of [4]B and the absence of [4]Al in samples with transition-metal content low enough to prevent paramagnetic quenching of the signal. Site populations were assigned from refined site-scattering values and unit formulae derived from electron-microprobe analyses of the crystals used for X-ray data collection. 57Fe Mössbauer spectroscopy shows that both Fe2+ and Fe3+ are present, and the site populations derived by structure refinement show that there is no Fe at the Z site; hence all Fe2+ and Fe3+ occurs at the Y site. The 57Fe Mössbauer spectra also show peaks due to intervalence charge-transfer involving Fe2+ and Fe3+ at adjacent Y sites. Calculation of the probability of the total amount of Fe occurring as Fe2+–Fe3+ pairs for a random short-range distribution is in close accord with the observed amount of Fe involved in Fe2+–Fe3+, indicating that there is no short-range order involving Fe2+ and Fe3+ in these tourmalines.
The crystal structure of khinite and polytypism in khinite and parakhinite
Authors: Cooper M. A. , Hawthorne F. C. , Back M. E. 
Published: November 2008

AbstractThe crystal structure of khinite, Pb2+Cu2+3Te6+O6(OH)2, orthorhombic, a = 5.7491(10), b = 10.0176(14), c = 24.022(3) Å, V = 1383.6(4) Å3, space group Fdd2, Z = 8, Dcalc = 6.29 g/cm3, from the Empire mine, Tombstone, Arizona, USA, has been solved by direct methods and refined to R1 = 3.2% on the basis of 636 unique observed reflections. There is one distinct Te site occupied by Te and coordinated by six O atoms in an octahedral arrangement with a <Te–O> distance of 1.962 Å. typical of Te6+. There are three octahedrally-coordinated Cu sites, each of which is occupied by Cu2+ with <Cu–O> distances of 2.132, 2.151 and 2.308 Å, respectively. Each Cu octahedron shows four short meridional bonds (~1.95 Å) and two long apical bonds (2.46–2.99 Å) characteristic of Jahn-Teller-distorted Cu2+ octahedra. There is one distinct Pb site occupied by Pb and coordinated by six O atoms and two (OH) groups with a <Pb–O, OH> distance of 2.690 Å. TeF6 and CuΦ6 octahedra share edges and corners to form an [MΦ2] (where Φ = O, OH) layer of composition [TeCu3Φ8]. These layers stack along the c axis at 6 A intervals with Pb atoms between the layers. Identical layers occur in the structure of parakhinite, Pb2+Cu2+Te6+O6(OH)2, hexagonal, a = 5.765(2), c = 18.001(9) Å, V =518.0(4) Å3, space group P32, Z = 3, Dcalc = 6.30 g/cm3. It is only the relative stacking of the TeCu3Φ8 layers in the c direction that distinguishes the two structures, and hence khinite and parakhinite are polytypes.
Chloroxiphite Pb3CuO2(OH)2Cl2: structure refinement and description in terms of oxocentred OPb4 tetrahedra
Authors: Siidra O. I. , Krivovichev S. V. , Turner R. W. , Rumsey M. S. 
Published: November 2008

AbstractThe crystal structure of chloroxiphite, Pb3CuO2(OH)2Cl2, from Merehead Quarry (monoclinic, P21/m, a = 6.6972(8), b = 5.7538(5), c = 10.4686(14) Å,β = 97.747(10)°, V = 399.72(8) Å3) has been refined to R1 = 0.041. The structure contains three symmetrically unique Pb sites and one Cu site. The strong distortion of the Pb2+ coordination polyhedra is due to the stereoactivity of the s2 lone electron pairs on the Pb2+ cations. The Cu-site is coordinated by four OH- groups to form an almost planar Cu(OH)4 square that is complemented by two apical Cl– anions, forming an elongated [Cu(OH)4Cl2] octahedron. Because of the large size and variability of coordination polyhedra around Pb2+ cations and the strength of the Me–O bonds in comparison to the Me–Cl bonds (Me = metal), it is convenient to describe the structure of chloroxiphite in terms of oxocentred OPb4 tetrahedra. The O1 atom is tetrahedrally coordinated by four Pb2+ cations forming relatively short and strong O–Pb bonds. The OPb4 tetrahedra link together via common edges to form [O2Pb3]2+ double chains. The difference between chloroxiphite and other natural oxyhalides is the presence of Cu2+ cations which form an independent structural unit that links to units formed by OPb4 tetrahedra. In this sense, chloroxiphite can be considered as a modular structure consisting of both strong cation- and anion-centred units.
Structured Overlay Networks as an Enabler for Future Internet ServicesStrukturierte Overlay Netze als Wegbereiter für NGI Dienste
Authors: Kunzmann Gerald , Binzenhöfer Andreas , Stäber Fabian 
Published: November 2008

Abstract
The next generation Internet will not only be defined by its technological progress but also by innovative Internet applications which offer new features, more interactivity, and a better user experience. Structured overlay networks, which create a well-defined virtual topology above the basic transport network, are a powerful means to easily create such Internet applications. There are many different approaches to realize structured overlay networks which in their core functions share the same basic principles. In this work we summarize the fundamentals of structured overlay networks, describe their inherent problems, and present an overview of our solutions. We then show how all these ideas have been put into practice in terms of a distributed carrier grade communication platform.
Bevacizumab and Erlotinib: A Promising New Approach to the Treatment of Advanced NSCLC
Authors: Herbst Roy S. , Sandler Alan 
Published: November 2008

AbstractBiologic agents that target molecules involved in tumor growth, progression, and pathological angiogenesis—such as the human epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF)—have demonstrated efficacy in patients with non-small cell lung cancer (NSCLC). Erlotinib (Tarceva®; OSI Pharmaceuticals, Inc., Melville, NY, Genentech, Inc., South San Francisco, CA, and F. Hoffmann-La Roche Ltd, Basel, Switzerland), a highly selective tyrosine kinase inhibitor that inhibits EGFR, and bevacizumab (Avastin®; Genentech, Inc., South San Francisco, CA, and F. Hoffmann-La Roche Ltd, Basel, Switzerland), a VEGF-targeted recombinant humanized monoclonal antibody, have displayed very encouraging activity in a randomized phase II trial in patients with previously treated NSCLC. Because erlotinib and bevacizumab act on two different pathways critical to tumor growth and dissemination, administering these drugs concomitantly may confer additional clinical benefits to cancer patients with advanced disease, by virtue of their complementary (or additive) antitumor activity. The combination of bevacizumab plus erlotinib may prove to be a viable second-line alternative to chemotherapy or erlotinib monotherapy in patients with NSCLC. The benefits of the combination may be further enhanced by selecting for patients who are likely to respond to this therapy. While a number of potential predictive markers have been identified for erlotinib, their value remains to be confirmed in prospective trials. In addition, the application of such personalized therapy will also depend on the availability of validated screening methods.
Putative Role of Functional Interferon Regulatory Factor 5 (IRF5) Polymorphism in Rheumatoid Arthritis in a Korean Population
Authors: KIM YUN JUNG , PARK JEONG HA , KIM IL , KIM JI ON , BAE JOON SEOL , SHIN HYOUNG DOO , BAE SANG-CHEOL 
Published: November 2008

ObjectiveRecent studies suggest that polymorphisms of interferon regulatory factor 5 (IRF5) are significantly associated with systemic lupus erythematosus in several populations. The effect of IRF5 polymorphism on susceptibility to rheumatoid arthritis (RA) has been investigated, and the results were inconsistent. We analyzed the genetic effects of IRF5 polymorphisms on RA in a Korean population.MethodsEight single-nucleotide polymorphisms (SNP) and 2 insertion-deletion polymorphisms in IRF5 were genotyped in 2183 subjects (1204 RA cases and 979 controls) using the TaqMan® method. The genetic effects of SNP on the risk of RA were evaluated using chi-square tests and multivariate logistic regression, controlling for age, sex, and shared epitope (SE), and we then performed conditional analysis by SE status and anti-cyclic citrullinated peptide (anti-CCP) antibody (Ab) status. Data from a Mantel-Haenszel metaanalysis of odds ratios (OR) were subsequently combined in a separate analysis with the results of the association of rs2004640 with RA from a previous study.ResultsTwo of the IRF5 polymorphisms, CGGGGindel (OR 1.38, 95% CI 1.09–1.76, pcorr = 0.04) and rs2004640 (OR 1.36, 95% CI 1.09–1.68, pcorr = 0.03), and one haplotype, including the rs2004640 and the CGGGGindel, ht3 (A-Del-T-C-del-A-T) (OR 1.39, 95% CI 1.09–1.79, pcorr = 0.04) were significantly associated with an increased risk of RA. After stratification according to anti-CCPAb and SE status, rs2004640 SNP was associated with the anti-CCPAb-positive (OR 1.47, 95% CI 1.15–1.88, pcorr = 0.01) or SE-positive group (OR 1.54, 95% CI 1.14–2.09, pcorr = 0.03). A combined analysis including all 3 independent cohorts from the previous study revealed an association of the rs2004640 with RA (pooled OR 1.21, 95% CI 1.07–1.38, pooled p = 0.0031 in dominant model).ConclusionOur results suggest that the IRF5 polymorphism is associated with genetic susceptibility to RA at least in a Korean population, and that it may contribute to disease susceptibility in SE-positive or anti-CCP Ab-positive patients with RA.
MAGE-B2 Autoantibody: A New Biomarker for Pediatric Systemic Lupus Erythematosus
Authors: HOFTMAN ALICE D.C. , TAI LEI-QIAN , TZE SHEILA , SELIGSON DAVID , GATTI RICHARD A. , McCURDY DEBORAH K. 
Published: November 2008

ObjectiveMelanoma-associated antigen gene B2 (MAGE-B2) encodes an embryonic antigen normally silenced after birth except in testis and placenta. We identified the MAGE-B2 gene and autoantibodies in pediatric patients with systemic lupus erythematosus (SLE) glomerulonephritis. We investigated the prevalence of MAGE-B2 autoantibodies in association with active SLE, to determine a pathogenetic role of MAGE-B2 protein through its distribution in cells and tissues.MethodsAcross-sectional study analyzed the frequency of MAGE-B2 autoantibodies in 40 patients with pediatric SLE, 23 adult controls, and 16 patients with pediatric juvenile rheumatoid arthritis (JRA) using Western blots containing recombinant MAGE-B2. SLE Disease Activity Index 2000 (SLEDAI-2K) and British Isles Lupus Assessment Group (BILAG) index measured SLE disease activity. Tissue distribution of MAGE-B2 protein was assessed by immunohistochemistry, immunofluorescence, and Western blots.ResultsSeventeen (43%) of 40 pediatric SLE patients had MAGE-B2 autoantibodies as compared to 0 of 16 JRA patients and 2 of 23 adult controls. SLE disease activity was significantly higher in MAGE-B2 autoantibody-positive versus autoantibody-negative patients (SLEDAI-2K, mean 10.9 vs 5.2, p = 0.013; BILAG, mean 15.3 vs 6.3, p = 0.023). Active nephritis was more prevalent (60% vs 24%) inMAGE-B2 autoantibody-positive than autoantibody-negative SLE patients. MAGE-B2 protein was visualized in SLE kidney proximal convoluted tubules and in tumor epithelial cells, but not in lymphoblastoid cells.ConclusionMAGE-B2 autoantibody appears to be a clinically relevant biomarker for pediatric SLE disease activity and nephritis.
Audiences, Intertextuality and new media literacy
Authors: Tyner Kathleen 
Published: November 2008

This article explores intertextuality as a technique that can be used to bridge old and new media literacies for teachers and students who hope to move beyond the textbook model of instruction into a world of online resources, flexible pedagogies and innovative designs for learning. These include the uses of online archives, media studies techniques, participatory knowledge creation, and multimedia analysis and production.
Este artículo explora la intertextualidad como una técnica que puede ser usada para tender un puente entre viejos y nuevos programas de alfabetización con los medios dirigidos a profesores y estudiantes que esperan pasar de un modelo de enseñanza basado en los libros de texto a un mundo de recursos on-line, pedagogías flexibles, técnicas de estudio de los medios, construcción interactiva del conocimiento y análisis y producción de multimedia.
Towards a democratic education of the look
Authors: Bustamante-Bohórquez Borys , Aranguren-Díaz Fernando , Chacón Maryori 
Published: November 2008

This article is based on the research project titled «Pedagogical uses of a quality television for child and youth audiences», by an inter-institutional agreement between the National Commission of Television and the District University «Francisco José de Caldas» of Bogota, Colombia. Its goal is to study the look in our socio-cultural life to promote a critical education of the audiovisual area, starting from pedagogical proposals which entail citizenship.
Este trabajo, basado en el proyecto de investigación «Usos pedagógicos de una televisión de calidad para audiencias infantiles y juveniles», de la Comisión Nacional de Televisión y la Universidad Distrital «Francisco José de Caldas» de Bogotá, Colombia, pretende estudiar la mirada en el espacio sociocultural que nos ha tocado vivir con el objeto de fomentar una educación crítica del ámbito audiovisual, partiendo de propuestas pedagógicas que impliquen a toda la ciudadanía.
Backstage of TV for children: criteria underlying programming construction
Authors: Pereira Sara 
Published: November 2008

What is usually known about television for children are the programmes broadcast. In contrast, the underlying criteria as well as their conditioning factors are largely unknown. This paper aims to unveil the television backstage, presenting and analysing the logics and strategic options that shape the conception, production and broadcasting of programming for children. In this way, this paper also intends to contribute to a well-grounded knowledge about a reality quite present in children’s daily life.Lo que popularmente se conoce de la televisión para niños es la parrilla de programación que se emite en las pantallas, pero existe una fase de creación previa (los llamados criterios de producción y el conjunto de factores que la condicionan) que es especialmente significativa para entender finalmente estos contenidos infantiles. Este trabajo pretende adentrarse en los «bastidores» de la televisión, presentando y analizando la lógica y opciones estratégicas en la concepción, producción y emisión de la programación dirigida al público más joven. Se pretende, de esta forma, contribuir a un mayor conocimiento de una realidad muy significativa presente en la vida cotidiana de los niños.
Television and young people in Spain
Authors: García-Matilla Agustín , Molina-Cañabate Juan Pedro 
Published: November 2008

The television is still the media with the biggest approach in Spanish homes. Despite this fact, it is no longer the main leisure and fun media for young people in the last years. This article tackles a historical context and aims for explaining some of the reasons why television has lost relevance within young audience. At the same time, the text provides a general perspective about some other screens consumption by young people, as well as it describes some alternative models and highlights new trends.
La televisión sigue siendo el medio con mayor grado de implantación en los hogares españoles; sin embargo, desde hace años se detecta una caída del «monopolio televisivo» en las preferencias de los jóvenes como único y exclusivo medio de ocio y diversión. En este trabajo se tratan de hallar algunas de las razones que expliquen que el medio televisivo haya perdido parte de su protagonismo entre la audiencia juvenil. Al mismo tiempo, se ofrece una perspectiva general acerca de los consumos de otras pantallas por parte de los jóvenes y se describen algunos modelos alternativos, así como tendencias y líneas prospectivas.
Materials Science in the Developing World: Challenges and Perspectives for Africa
Authors: Rosei Federico , Vayssieres Lionel , Mensah Patrick 
Published: November 2008

Abstract“Africans believe in something that is difficult to render in English. We call it ubuntu or botho. It means the essence of being human. You know when it is there and when it is absent. It speaks about humanness, gentleness, hospitality, putting yourself out on behalf of others, being vulnerable. It embraces compassion and roughness. It recognizes that my humanity is bound up in yours, for we can only be human together” (Desmond Tutu)
Molecular Factors of Catalytic Selectivity
Authors: Somorjai Gabor A. , Park Jeong Y. 
Published: November 2008

AbstractSelectivity—the production of one molecule out of many other thermodynamically feasible product molecules—is the key concept in developing clean processes that do not produce by‐products (green chemistry). Small differences in the potential‐energy barriers of single reaction steps control which reaction channel is more likely to yield the desired product molecule (selectivity), while the overall activation energy of the reaction controls the turnover rates (activity). Recent studies have demonstrated that tailoring parameters at the atomic or molecular level—such as the surface structures of active sites—gives turnover rates and reaction selectivities that depend on the nanoparticle size and shape. Here, we highlight seven molecular components that influence the selectivity of heterogeneous catalyst reactions on single‐crystal model surfaces and colloid nanoparticles: surface structure, adsorbate‐induced restructuring, adsorbate mobility, reaction intermediates, surface composition, charge transport, and oxidation states. We show the importance of the single factors by means of examples and describe in situ analyses that permit their roles in surface reactions to be investigated.
Cruciform‐Silica Hybrid Materials
Authors: Zucchero Anthony J. , Shiels Rebecca A. , McGrier Psaras L. , To M. Alicia , Jones Christopher W. , Bunz Uwe H. F. 
Published: November 2008

AbstractSilica scaffolding: By employing functionalized mesoporous SBA‐15 silica, novel fluorescent cruciform‐silica hybrid materials are generated which preserve the desirable solution properties of cruciforms in the solid state for potential use in sensory schemes.magnified imagePreserving the solution properties of functional fluorophores upon incorporation into solid state sensory schemes remains a significant challenge. To address this concern, a silica scaffold was employed to support functional fluorophores in the solid state. Herein, we report an effort to support 1,4‐distyryl‐2,5‐bisarylethynylbenzene cruciforms (XFs) using functionalized mesoporous silica particles. By employing surface‐functionalized mesoporous SBA‐15 silica, novel fluorescent cruciform‐silica hybrid materials are generated which retain the desirable solution properties of cruciforms in the solid state. Organic surface functionalities, such as acidic, basic, and hydrophobic groups employed on the silica scaffold, modulate the observed emissions of the resulting solid state materials. The potential of these XF‐silica hybrid materials to display sensory responses to representative vapor‐phase analytes is demonstrated.
CV‐ANOVA for significance testing of PLS and OPLS® models
Authors: Eriksson Lennart , Trygg Johan , Wold Svante 
Published: November 2008

AbstractThis report describes significance testing for PLS and OPLS® (orthogonal PLS) models. The testing is applicable to single‐Y cases and is based on ANOVA of the cross‐validated residuals (CV‐ANOVA). Two variants of the CV‐ANOVA are introduced. The first is based on the cross‐validated predictive residuals of the PLS or OPLS model while the second works with the cross‐validated predictive score values of the OPLS model. The two CV‐ANOVA diagnostics are shown to work well in those cases where PLS and OPLS work well, that is, for data with many and correlated variables, missing data, etc. The utility of the CV‐ANOVA diagnostic is demonstrated using three datasets related to (i) the monitoring of an industrial de‐inking process; (ii) a pharmaceutical QSAR problem and (iii) a multivariate calibration application from a sugar refinery. Copyright © 2008 John Wiley & Sons, Ltd.
Improvement of a Stereoselective Biocatalytic Synthesis by Substrate and Enzyme Engineering: 2‐Hydroxy‐(4′‐oxocyclohexyl)acetonitrile as the Model
Authors: Avi Manuela , Wiedner Romana M. , Griengl Herfried , Schwab Helmut 
Published: November 2008

AbstractEven if biocatalysis is finding increasing application, it still has to gain widespread use in synthetic chemistry. Reasons for this are limitations that enzymes have with regard to substrate range, reaction scope, and insufficient selectivity with unnatural compounds. These shortcomings can be challenged by enzyme and/or substrate engineering, which are employed to alter substrate specificity and enhance the enzyme selectivity toward unnatural substrates. Herein, these two approaches are coupled to improve the hydroxynitrile lyase catalyzed synthesis of 2‐hydroxy‐(4′‐oxocyclohexyl)acetonitrile (4). The ketone functionality is masked as an enol ether, and the oxynitrilase of Hevea brasiliensis is engineered towards this masked substrate to give the product with a high optical purity and to drastically lower the amount of enzyme needed.
9,10‐Diarylanthracenes as Molecular Switches: Syntheses, Properties, Isomerisations and Their Reactions with Singlet Oxygen
Authors: Zehm Daniel , Fudickar Werner , Hans Melanie , Schilde Uwe , Kelling Alexandra , Linker Torsten 
Published: November 2008

AbstractA series of 9,10‐diarylanthracenes with various substituents at the ortho positions have been synthesised by palladium‐catalysed cross‐coupling reactions. Such compounds exhibit interesting physical properties and can be applied as molecular switches. Despite the high steric demand of the substituents, products were formed in moderate‐to‐good yields. In some cases, microwave conditions further improved yields. Bis‐coupling afforded two isomers (syn and anti) that do not interconvert at room temperature. These products were easily separated and their relative stereochemistries were unequivocally assigned by NMR spectroscopy and X‐ray analysis. The syn and anti isomers exhibit different physical properties (e.g., melting points and solubilities) and interconversion by rotation around the aryl–aryl axis commences at <100 °C for fluoro‐substituted diarylanthracenes and at >300 °C for alkyl‐ or alkoxy‐substituted diarylanthracenes. The reactions with singlet oxygen were studied separately and revealed different reactivities and reaction pathways. The yields and reactivities depend on the size and electronic nature of the substituents. The anti isomers form the same 9,10‐endoperoxides as the syn species, occasionally accompanied by unexpected 1,4‐endoperoxides as byproducts. Thermolysis of the endoperoxides exclusively yielded the syn isomers. The interesting rotation around the aryl–aryl axis allows the application of 9,10‐diarylanthracenes as molecular switches, which are triggered by light and air under mild conditions. Finally, the oxygenation and thermolysis sequence provides a simple, synthetic access to a single stereoisomer (syn) from an unselective coupling step.