bluuebunny/crossref_metadata_2025_split huggingface dataset:
Olaparib not cost-effective as maintenance therapy for platinum-sensitive, BRCA1/2 germline-mutated metastatic pancreatic cancer
Authors: Mehra Tarun , Lupatsch Judith E. , Kössler Thibaud , Dedes Konstantin , Siebenhüner Alexander Reinhard , von Moos Roger , Wicki Andreas , Schwenkglenks Matthias E. 
Published: April 2024

Objective
To assess the cost-effectiveness and budget impact of olaparib as a maintenance therapy in platinum-responsive, metastatic pancreatic cancer patients harboring a germline BRCA1/2 mutation, using the Swiss context as a model.

Methods
Based on data from the POLO trial, published literature and local cost data, we developed a partitioned survival model of olaparib maintenance including full costs for BRCA1/2 germline testing compared to FOLFIRI maintenance chemotherapy and watch-and-wait. We calculated the incremental cost-effectiveness ratio (ICER) for the base case and several scenario analyses and estimated 5-year budget impact.

Results
Comparing olaparib with watch-and wait and maintenance chemotherapy resulted in incremental cost-effectiveness ratios of CHF 2,711,716 and CHF 2,217,083 per QALY gained, respectively. The 5-year costs for the olaparib strategy in Switzerland would be CHF 22.4 million, of which CHF 11.4 million would be accounted for by germline BRCA1/2 screening of the potentially eligible population. This would amount to a budget impact of CHF 15.4 million (USD 16.9 million) versus watch-and-wait.

Conclusions
Olaparib is not a cost-effective maintenance treatment option. Companion diagnostics are an equally important cost driver as the drug itself.
Prevalence and risk factors of early postoperative seizures in patients with glioma: A protocol for meta-analysis and systematic review
Authors: Sun Bo , Lu Wenpeng , Yu Wangyang , Tian Ye , Wang Peng 
Published: April 2024

Introduction
Early postoperative seizures has been the most common clinical expression in gliomas; however, the incidence and risk factors for early postoperative seizures in gliomas are more controversial. This protocol describes a systematic review and meta-analysis to clarify the prevalence and risk factors of early postoperative seizures in patients with glioma.

Methods and analysis
Searches will be conducted on CNKI, WanFang, VIP, PubMed, Embase, Cochrane Library databases and Web of Science for the period from database inception to December 31st, 2023. Case-control and cohort studies of the incidence and risk factors for early postoperative seizures in all gliomas will be included. The primary outcome will be incidence, risk factors. Newcastle-Ottawa Scale was used for quality evaluation. Review of article screening, extracting data and risk of bias assessment will be repeated by two independent reviewers.

Result
This study will provide evidence for the risk factors and incidence of early postoperative seizures in patients with glioma.

Conclusion
Our study will provide evidence for the prevention of early postoperative seizures in glioma patients.

Trail registration
This protocol was registered in PROSPERO and registration number is CRD42023415658.
Association between rosacea and helicobacter pylori infection: A meta-analysis
Authors: Gao Ying , Yang Xiao-jing , Zhu Yun , Yang Ming , Gu Fei 
Published: April 2024

Background and objectives
The potential association between rosacea and a heightened prevalence of Helicobacter pylori (HP) infection has been previously suggested. However, existing studies offer inconsistent results. This systematic review and meta-analysis aimed to elucidate the relationship between rosacea and HP infection.

Methods
We conducted comprehensive searches of PubMed, Embase, and Web of Science databases to identify relevant observational studies for our investigation. We utilized the random-effects model to aggregate the data to address the potential influence of heterogeneity among the studies on the outcome.

Results
Our analysis incorporated twenty-five datasets from 23 case-control and cross-sectional studies, encompassing 51,054 rosacea patients and 4,709,074 controls without skin disease. The pooled results revealed a significantly higher prevalence of HP infection in individuals with rosacea compared to controls (odds ratio [OR]: 1.51, 95% confidence interval [CI]: 1.17–1.95, p<0.001; I2 = 79%). Subgroup analysis indicated an increased prevalence of HP infection in rosacea studies that utilized one (OR: 1.72, 95% CI: 1.11–2.66, p = 0.02; I2 = 76%) or more tests for HP infection (OR: 2.26, 95% CI: 1.29–3.98, p = 0.005; I2 = 56%). However, this association was not observed in population-based studies that determined HP infection based on prescription records for HP eradication drugs (OR: 0.90, 95% CI: 0.76–1.07, p = 0.024; I2 = 54%).

Conclusion
Rosacea may be significantly associated with a higher prevalence of HP infection. High-quality prospective studies with delicately controlled confounding factors are needed to determine if HP infection is a risk factor for rosacea.
Production, Quality Test, and Activity Evaluation of Methanol Extract and Nanoparticles from Pluchea indica (L.) Leaves as Additives in Natural Soap against Propionibacterium acnes
Authors: Saputra Arsya Cahya , Wiratama Elang Seta , Mayangsari Fiyola , Divinka Oktafinantyas Via , Handayani Sri 
Published: April 2024

Pluchea indica (L.) leaves, both in the form of extracts and silver nanoparticles, are known to exhibit antibacterial activity, but they have not been widely utilized in the health sector, especially in dermatology. This study aims to determine the quality test and antibacterial evaluation of natural soap formulated with methanol extract and nanoparticles of Pluchea indica (L.) leaves against Propionibacterium acnes. The synthesis of silver nanoparticles (AgNPs) was conducted using the reduction method, with AgNO3 as a precursor and methanol extract of Pluchea indica (L.) leaves serving as a reducing agent or bioreductor. Natural soap was produced through the cold process method, with a curing period of 3 to 4 weeks. Natural soap, derived from herbal ingredients, was made by combining NaOH, essential oils, and additives such as methanol extract and silver nanoparticles from Pluchea indica (L.) leaves. Quality tests were performed to assess moisture content (MC), fatty acid content, and pH levels. Antibacterial activity was assessed utilizing the well-diffusion method, with various sample concentrations ranging from 1.0 g/mL to 0.0625 g/mL. The quality test results for all soap samples met the Indonesian National Standard (SNI) requirements for acidity, free fatty acids, and moisture content. The bar soap without additives exhibited antibacterial activity, with a maximum inhibition zone of 14.26 mm (at 0.25 g/mL) after 15 hours. Natural soap with methanol extract of Pluchea indica (L.) leaf demonstrated an inhibition zone of 11.49 mm (at 0.0625 g/mL) after 15 hours, while nanoparticle soap exhibited an inhibition zone of 12.77 mm (at 0.25 g/mL) after 12 hours. In summary, all soap samples showed antibacterial activity, indicating the potential of Pluchea indica (L.) leaves as effective antibacterial agents.
Ultra-deep channel sand body target recognition method based on improved deep learning under UAV cluster
Authors: Guan Jingxin , Ma Weimin 
Published: April 2024

Abstract
River sand bodies have complex and changeable characteristics and distribution. In order to improve the accuracy and efficiency of target recognition, this study proposes a target recognition method of ultra-deep river sand bodies with improved deep learning under unmanned aerial vehicle (UAV) cluster. By constructing the cooperative target allocation model of UAV group, it is ensured that the targets of ultra-deep and large-area river sand bodies are collected. The gradient histogram is used to extract the image characteristics of ultra-deep river sand body and enhance the target image of ultra-deep river sand body. Bi-directional long short-term memory (Bi-LSTM) network model is constructed by introducing bidirectional recurrent neural network (RNN) to improve deep learning. Bi-LSTM neural network is used to construct the target recognition model of ultra-deep river sand body and complete the target recognition. The experimental results show that this method can extract the target edge completely and recognize the image edge accurately, and the average recognition accuracy under different ambiguities is higher than 95. It is proved that this method has high accuracy in sand body feature extraction and classification and has great application potential in river sand body target recognition.
Healthcare professionals’ experience of teenage pregnancy and motherhood in Haiti
Authors: Philibert Léonel , Lapierre Judith , Mulatris Paulin , Kiki Gbètogo Maxime , Prophète Alice , Ntanda Gisèle Mandiangu 
Published: April 2024

Abstract

Objectives
The aim of this study was to explore healthcare professionals’ experience of pregnant and motherhood in adolescence in Haiti.

Methods
The methodology for collecting and analyzing qualitative data was based on John Dewey’s social survey. The study was conducted in nine health institutions in the North and North-East departments of Haiti from October 2020 to January 2021. Data were collected through individual semi-structured interviews with 15 healthcare professionals. All interviews were audio-recorded. The recordings were listened to carefully and transcribed in verbatim form. After checking and validation, the verbatims in Word format were exported to QDA Miner software version 6.0.5 for coding. The data were analyzed using Paillé and Mucchielli thematic analyses.

Results
Health professionals such as gynecologists, nurses, midwives, nursing assistants, matrons and health workers took part in the study. These study participants indicate that teenage pregnancy and motherhood are social and public health problems whose negative consequences affect teenage girls, children, healthcare professionals, the healthcare system, and Haitian society in general. The services offered to adolescent girls are medical, educational, psychological, economic, and social in nature. When caring for pregnant adolescents during the transition to motherhood, healthcare professionals face many challenges that are linked to the socio-economic status and physiological reality of adolescents, as well as the healthcare system.

Conclusions
Programs involving home care visits should also be set up to offer ongoing support to pregnant or parenting teenagers. The distribution of food aid or materials such as clothing, hygiene products and baby kits should also be considered.
Analysis and computation of a weak Galerkin scheme for solving the 2D/3D stationary Stokes interface problems with high-order elements
Authors: Kumar Raman , Deka Bhupen 
Published: April 2024

Abstract
In this paper, we present a high-order weak Galerkin finite element method (WG-FEM) for solving the stationary Stokes interface problems with discontinuous velocity and pressure in ℝ
d
, d = 2, 3. This WG method is equipped with stable finite elements consisting of usual polynomials of degree k ⩾ 1 for the velocity and polynomials of degree k − 1 for the pressure, both are discontinuous. Optimal convergence rates of order k + 1 for the velocity and order k for the pressure are established in L
2-norm on hybrid meshes. Numerical experiments verify the expected order of accuracy for both two-dimensional and three-dimensional examples. Moreover, numerically it is shown that the proposed WG algorithm is able to accommodate geometrically complicated and very irregular interfaces having sharp edges, cusps, and tips.
Crystal structure of N-(1-(3,4-dimethoxyphenyl)-2-methylpropyl)aniline, C18H23NO2
Authors: Zhu Qian , Yao Zhen 
Published: April 2024

Abstract
C18H23NO2, monoclinic, C2/c (no. 15), a = 23.188(2) Å, b = 7.9820(5) Å, c = 20.6004(15) Å, β = 119.696(7)°, V = 3312.1(5) Å3, Z = 8, Rgt
(F) = 0.0923, wRref
(F
2) = 0.1920, T = 293 K.
A numerical investigation of the two-dimensional magnetohydrodynamic water-based hybrid nanofluid flow composed of Fe3O4 and Au nanoparticles over a heated surface
Authors: Yasmin Humaira , Lone Showkat Ahmad , Alrabaiah Hussam , Raizah Zehba , Saeed Anwar 
Published: April 2024

Abstract
In this research article, the viscous, steady, and incompressible two-dimensional hybrid nanofluid flow composed of Fe3O4 and Au nanoparticles on an extending sheet has been presented. An inclined magnetic field impact is used for evaluating the impacts of various factors in that case. Furthermore, the influences of porosity, Brownian motion, thermophoresis, thermal and space-dependent heat sources, and thermal radiation factors are also used in this work. The numerical analysis is done by using the bvp4c technique. Validation of the present results confirms that the present analysis is valid. The outcomes show that the higher magnetic factor reduces velocity distribution while increasing the frictional force at the surface due to Lorentz forces which oppose the fluid flow. The friction force at the sheet’s surface is higher when the sheet stretches as compared to the case when the sheet shrinks. Increase in the magnetic factor increases the skin friction of sheet’s surface which consequently increases the rate of thermal transmission at the surface along with thermal distribution. The higher values of thermal radiation and thermal-dependent heat source increase the thermal transportation rate of sheet’s surface. Insights from this investigation can improve electronics cooling systems, vital for devices prone to overheating. Optimizing heat transfer with magnetohydrodynamic water-based hybrid nanofluids containing Fe3O4 and Au nanoparticles ensures efficient heat dissipation, enhancing device performance and longevity.
Methods of Modelling Electronic Academic Libraries: Technological Concept of Electronic Libraries
Authors: Kolbayev Nurbolat , Tuyenbayeva Kalima , Seitimbetova Danakul , Apakhayev Nurlan 
Published: April 2024

Abstract
The relevance of examining modelling methods in academic electronic libraries is justified by the need to understand the library’s structure and ensure its operation in technological terms. The purpose of this study is to analyse the applied modelling methods for electronic libraries serving Kazakhstani and international higher education institutions. The study employed basic (structural, comparative-comparative) and additional (analytical-synthetic, graphical) methods. During this study, it was found that the main modelling methods for modern electronic libraries include the following: conceptual with the establishment of a clear hierarchy between objects of the electronic library and attributes of search queries, logical using search categorisation, informational employing the semantic principle of material construction and systemic-functional ensuring a balance between functions, structure, technologies and the management system. In particular, after modelling the structure of Kazakhstani, British and American digital libraries at universities, it was determined that the Yale University Electronic Library Collection is built on the method of logical modelling, the Electronic Library at L.N. Gumilyov Eurasian National University uses the systemic-functional method, the Cambridge University Electronic Library employs the informational method and the Al-Farabi Library uses the conceptual method.
Gamma and neutron attenuation of SiO2–B2O3–BaO–Li2O glasses doped with CeO2
Authors: Alsafi Khalid , Aloraini Dalal Abdullah , Saif M. A. , Shaaban Kh. S. 
Published: April 2024

Abstract
The demonstrations impact of CeO2 on the radiation shielding properties of SiO2–B2O3–BaO–Li2O glasses has been investigated. The observed trend in density ρ ranged from 3.127 to 4.022 g/cm³, whereas the molar volume V

m
of these glasses decreased. The half-value layers (HVL), and mean free paths (MFP) of CL glasses reinforce the notion that the presence of Ce ions, particularly in CL2, enhances the ability of glasses’ to attenuate gamma rays. The effective electron density (N
eff) increases with the addition of CeO2, suggesting a correlation between the enhancement of radiation shielding properties and the amount of CeO2 incorporated into the glasses.
Embrittlement, degradation, and loss prevention of hydrogen pipelines
Authors: Giannini Leonardo , Razavi Nima , Alvaro Antonio , Paltrinieri Nicola 
Published: April 2024

AbstractThe detrimental effects induced by hydrogen on different materials—including steels—are a well-known and studied phenomenon. In the last century, several research papers focusing on hydrogen damages were published, including investigations concerning the hydrogen impact on the crack growth rate in steels subjected to cyclic loading. However, the past studies focused on material behavior and the role of external factors (e.g., pressure, temperature, stress field, microstructure, inhibitors, etc.), while the consequences of these findings on safety procedures and guidelines remain unspoken. The present work aims at investigating how the manifestation of the hydrogen degradation effect on equipment subjected to fatigue loadings may reflect on conventional safety practices. More accurately, a review of the parameters governing pipeline fatigue life is undertaken to analyze how such variables may lead to undesirable events and ultimately promoting a loss of containment scenario. In this sense, this work appeals for an evolution of the existing inspection methodologies for components that may experience fatigue failures (i.e., piping and pipeline systems), since the time-dependency of the detrimental effects induced by hydrogen should be considered in the operations of accident prevention and risk mitigation. Hence, the development of a preventive inspection and maintenance strategy specifically conceived for hydrogen technologies is essential to avoid the loss prevention of hydrogen systems. This will not only contribute to a quicker and larger scale spread of a hydrogen infrastructure, but it will also foster the energy-transition challenge that our society is facing today.
Graphical abstract
Effect of maltodextrin concentration and drying temperature on the physicochemical characteristics of Sacha inchi (Plukenetia volubilis) extract powder
Authors: Hariadi Hari , Wahyono Teguh , Darniadi Sandi , Maulana Haris , Nurhadi Bambang , Amien Suseno , Karuniawan Agung , Ali Khan Ayaz , Aziz Tariq , F. Alasmari Abdullah 
Published: April 2024

Sacha inchi (Plukenetia volubilis L.) is an ancestral plant with various beneficial properties and has been used as a food source due to its high nutritional value for human health. The aim of this study was to assess the effect of the addition of maltodextrin concentration, the impact of the use of drying temperature, and the interaction of both on the physicochemical characteristics of powdered Sacha inchi extract. The results of this study would provide insightful information about the utilization of Sacha inchi, the optimal concentration of maltodextrin, and the drying temperature of powdered Sacha inchi extract. The experimental design used in this study is a Randomized Group Design with a 3x3 factorial pattern of two replications followed by Duncan’s further test. The observed variation consisted of maltodextrin concentration (5%, 10%, and 15%) and drying temperature (50°C, 60°C, and 70°C). This study includes chemical and physical responses such as moisture content, antioxidant activity, yield, solubility, hygroscopicity, and scanning electron microscopy (SEM). The effect of maltodextrin concentration and drying temperature factor was significant on moisture content, hygroscopicity, yield, and solubility. The interaction between drying temperature and maltodextrin concentration significantly affected moisture content and solubility.
Synthesis and characterization of chitosan-based pH-sensitive biofilm: An experimental design approach for release of vitamin B12
Authors: Onal Ali , Demir Hulya , Kaplan Ince Olcay , Ince Muharrem 
Published: April 2024

Hydrogels because of their unique potentials, such as highwater content and hydrophilicity, are of interest for the controlled release of drug molecules. In the present study, a biofilm was produced using chitosan, a natural polymer. Characterization analyses of the synthesized biofilm were performed using Fourier-transform infrared spectroscopy (FT-IR), thermogravimetric analysis-differential thermal analysis, x-ray diffraction, and scanning electron microscopy-energy dispersive x-ray spectrometry. The analysis results of the film before loading were compared to the analysis made after adding vitamin B12 to the film. The release percentage of vitamin B12 was investigated by using ultraviolet-visible spectrophotometery. The FT-IR bands of vitamin B12 were in the range of 2,800-3,500 cm-1 and 1,000 cm-1-1,750 cm-1. When pH increased from 3 to 7, release of vitamin B12 from the biopolymer increased up to pH 5. While examining the release potential, parameters, such as pH, initial concentration of vitamin B12, release time, and solution volume, were optimized by using response surface methodology. It was determined that with the increase in release time and the initial concentration, pH contributed positively to the release of vitamin B12. The following conditions were determined for release of vitamin B12 from the biofilm: pH: 4.2, initial concentration of vitamin B12: 54.0 mg L-1, the release time: 117 min, and volume of solution: 2.1 mL. The analysis of variance results showed that the determination coefficients for the use of synthesized biofilm in vitamin B12 release were high and R2 =0.9704.
Karakteristik mutu dan kandungan senyawa volatil bekasam cumi-cumi dengan lama fermentasi yang berbeda
Authors: Ramadhanti Bella Widya , Sumardianto Sumardianto , Romadhon Romadhon 
Published: April 2024

Cumi-cumi (Uroteuthis chinensis) digemari masyarakat Indonesia karena memiliki rasa enak dan tekstur yang unik. Pengolahannya menjadi produk bekasam dapat membuat cumi-cumi bertahan lama dan meningkatkan nilai gizi. Tujuan penelitian ini untuk menentukan lama waktu fermentasi terbaik bekasam cumi-cumi melalui karakteristik mutu kimia, bakteri asam laktat, sensori dan kandungan senyawa volatil. Pembuatan bekasam cumi-cumi dengan perendaman larutan garam 15% dan pemberian karbohidrat nasi 40% (b/b), selanjutnya dilakukan proses fermentasi. Lama fermentasi yang digunakan untuk membuat bekasam perlu diperhatikan karena berpengaruh terhadap mutu bekasam. Metode penelitian yang digunakan adalah experimental laboratories menggunakan rancangan acak lengkap (RAL) dengan perlakuan lama fermentasi yang berbeda, yaitu 3, 5, dan 7 hari dengan 3 kali ulangan. Data parametrik dianalisis menggunakan ANOVA dan uji lanjut Tukey HSD. Data nonparametik dianalisis menggunakan Kruskal Wallis dan uji lanjut Mann Whitney. Parameter yang diuji adalah kadar air, pH, total BAL, sensori, dan kandungan senyawa volatil. Bekasam cumi-cumi dengan lama fermentasi 3 hari memberikan hasil yang terbaik dengan kadar air 62,11%; pH 4,07; total bakteri asam laktat 9,05 log cfu/g dan uji hedonik dengan nilai selang kepercayaan sebesar 3,75 ˂µ< 4,05. Senyawa volatil yang dominan, yaitu golongan ester, alkohol dan amin. Senyawa lainnya yang teridentifikasi yaitu golongan asam, aldehid, keton, terpenoid, karotenoid, seskuiterpenoid, fenilpropanoid, hidrokarbon aromatik, dan karbonil. Pengolahan cumi-cumi menjadi produk bekasam memerlukan waktu fermentasi selama 3 hari untuk menghasilkan produk bekasam cumi-cumi yang baik.