bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immediate-Early Genes as Influencers in Genetic Networks and their Role in Alzheimer’s Disease
Authors: Zachariou Margarita , Loizidou Eleni M. , Spyrou George M. 
Published: March 2024

Abstract/SummaryImmediate-early genes (IEGs) are a class of activity-regulated genes (ARGs) that are transiently and rapidly activated in the absence of de novo protein synthesis in response to neuronal activity. We explored the role of IEGs in genetic networks to pinpoint potential drug targets for Alzheimer’s disease (AD). Using a combination of network analysis and genome-wide association study (GWAS) summary statistics we show that (1) IEGs exert greater topological influence across different human and mouse gene networks compared to other ARGs, (2) ARGs are sparsely involved in diseases and significantly more mutational constrained compared to non-ARGs, (3) Many AD-linked variants are in ARGs gene regions, mainly inMARK4near FOSB, with an AD risk eQTL that increasesMARK4expression in cortical areas, (4)MARK4holds an influential place in a dense AD multi-omic network and a high AD druggability score. Our work on IEGs’ influential network role is a valuable contribution to guiding interventions for diseases marked by dysregulation of their downstream targets and highlightsMARK4as a promising underexplored AD-target.HighlightsImmediate-early genes are topologically influential in brain genetic networks in mouse and human.Activity-regulated Genes (ARGs) are highly constrained with sparse gene-disease relevance.There are several AD-associated variants in ARGs gene regions, mainly inMARK4nearFOSB.GWAS and network analysis of ARG’s pinpointMARK4as a promising underexplored AD target.
Tumour-derived extracellular vesicles within the therapy-induced senescent secretome distinctly suppress breast cancer via DKK1-mediated inflammatory response
Authors: Robert Matius , Jakhar Rekha , Au Bijin Veonice , Eng Gracie Wee Ling , Wei Meng , Gao Alvin Kunyao , Chuah You Heng , Sachaphibulkij Karishma , Bonne Isabelle , Lim Kah Jing , Sinha Indrajit , Teh Daniel Boon Leng , Lim Lina Hsiu Kim , Kumar Prashant , Verma Navin Kumar , Sze Newman Siu Kwan , Lim Elaine Hsuen , Ong Derrick Sek Tong , Cheong Jit Kong , Itahana Koji , Connolly John Edward , Crasta Karen Carmelina 
Published: March 2024

ABSTRACTTriple-negative breast cancers (TNBC), associated with poor prognosis and high tumour recurrence, are often-treated with taxanes in first-line treatment regimens. However, acquired disease resistance can often set in, hampering clinical efficacy. One avenue that could engender therapy resistance is therapy-induced senescence (TIS), as they represent a population of residual disease and are highly secretory. Although it is known that TIS can contribute to tumour development and therapy resistance via the therapy-induced secretome, the underlying molecular mechanisms are not fully understood. In this study, we sought to dissect the role of the TNBC-derived TIS-associated secretome in chemoresponse. We found that paclitaxel-treated cells induced mitotic slippage and entered senescence as tetraploid cells. The therapy-induced SASP was found to be enriched in soluble cytokines and other pro-tumorigenic factors linked to tumour recurrence and distant metastasis. Interestingly, we found that senescence-associated small extracellular vesicles (sEVs) or exosomes, an underappreciated component of SASP, increased genomic instability, ROS and anti-tumour activity. Exosomal proteomic and transcriptomic profiling further revealed DKK1, a negative regulator of WNT signalling, to be enriched in TIS-sEVs. Further investigation demonstrated DKK1-control of inflammatory cytokines production to confer reduced tumour activity in recipient TNBC cancer cells. Taken together, this study revealed unexpected findings where TIS-sEVs confer opposing tumourigenic outcomes to that elicited by TIS-SASP, indicating that sEVs should be considered as distinct SASP entities.
Parent-specific transgenerational immune priming enhances offspring defense – unless heat-stress negates it all
Authors: Schneider Ralf F , Dubin Arseny , Marten Silke-Mareike , Roth Olivia 
Published: March 2024

AbstractTrans-generational immune priming (TGIP) adjusts offspring immune responses based on parental immunological experiences - a form of trans-generational plasticity predicted to be adaptive when parent-offspring environmental conditions match. In contrast, mis-matches between environmental conditions negate those advantages, rendering TGIP costly when mismatched immunological offspring phenotypes are induced. Particularly maternal TGIP was thought to shape offspring immunological preparedness: mothers’ eggs contain more substance than sperm and, in viviparous species, pregnancy provides additional avenues for immune priming of developing offspring. The syngnathids’ (pipefishes and seahorses) unique male pregnancy provides an unusual perspective to the ecological relevance of TGIP in a system where egg production and pregnancy occur in different sexes. We simulated parental bacteria exposure in broad nosed pipefish,Syngnathus typhle, through vaccinations with heat-killedVibrio aestuarianusbefore mating the fish to each other or control individuals. Resulting offspring were raised, and some exposed toV. aestuarianus, in a control or heat-stress environment, after which transcriptome and microbiome compositions were investigated. Transcriptomic TGIP effects were only observed inVibrio-exposed offspring at control temperatures, arguing for low costs of TGIP in non-matching environments. Transcriptomic phenotypes elicited by maternal and paternal TGIP had only limited overlap and were not additive. Both transcriptomic responses were significantly associated to immune functions, and specifically the paternal response to the innate immune branch. TGIP of both parents reduced the relative abundance of the experimentalVibrioin exposed offspring, showcasing its ecological effectiveness. Despite its significance in matching biotic environments, no TGIP-associated phenotypes were observed for heat-treated offspring. Heat-spikes caused by climate change thus threaten TGIP benefits, potentially increasing susceptibility to emerging marine diseases. This highlights the urgent need to understand how animals will cope with climate-induced changes in microbial assemblages by illustrating the importance – and limits - of TGIP in mitigating the impacts of environmental stressors on offspring vulnerability.
In quiescent G0 phase,Schizosaccharomyces pombeMis4 ensures full nuclear separation during the subsequent M phase
Authors: Suma Michiko , Arakawa Orie , Tahara Yuria , Sajiki Kenichi , Saitoh Shigeaki , Yanagida Mitsuhiro 
Published: March 2024

SummaryEvolutionarily conserved Mis4 establishes cohesion between replicated sister chromatids in vegetatively proliferating cells. In the fission yeast,Schizosaccharomyces pombe, defects in Mis4 lead to premature separation of sister chromatids, resulting in fatal chromosome mis-segregation during mitosis. In humans, NIPBL, an ortholog of Mis4, is responsible for a severe multisystem disorder called Cornelia de Lange syndrome. We previously reported that Mis4 is also essential in non-proliferating quiescent cells. Whereas wild-type fission yeast cells can maintain high viability for long periods without cell division in the quiescent G0 phase,mis4-450mutant cells cannot. In this report, we show that Mis4 is not required for cells to enter G0 phase, but is essential to exit from it. When resuming mitosis after passage of G0,mis4mutant cells segregated sister chromatid successfully, but insufficiently separated daughter nuclei consequently formed dikaryon-like cells. These findings suggest a novel role of Mis4/NIPBL in non-dividing quiescent cells, which is prerequisite for full nuclear separation upon resumed mitosis. As most human cells are in the quiescent state, this study may facilitate development of novel therapies for human diseases caused by Mis4/NIPBL deficiency.
Temperature dependence of refractive indices of
InP
,
GaAs
,
AlAs
, and
In0.53Ga0.47As
in the midinfrared spectral range determined by combined ellipsometry and Fourier-transform spectroscopy
Authors: Mikulicz Monika , Smolka Tristan , Rygala Michal , Badura Mikolaj , Kijaszek Wojciech , Lozińska Adriana , Kamp Martin , Motyka Marcin 
Published: April 2024

We present the results of Fourier-transform measurements for determination of refractive indices of four semiconductor alloys in the midinfrared spectral range from 10 to 300 K. We investigate double-sided-polished, undoped InP and GaAs substrates as well as In0.53Ga0.47As/InP and AlAs/GaAs distributed Bragg reflector (DBR) mirrors with their operational wavelength designed for 4 µm. Through analysis of measured transmittance spectra supported by ellipsometry it is possible to determine the temperature-dependent refractive indices of InP and GaAs from 1.3 to 11 µm. Furthermore, by using reflectivity measurements supported by numerical modeling of the two types of designed DBR structures the refractive indices of In0.53Ga0.47As and AlAs for around 4 µm are determined with their temperature dependencies. Data acquired through this method could lead to improvement of already existing optical semiconductor devices expanding their application for longer wavelengths.

Published by the American Physical Society
2024
Combined experimental and theoretical studies on glasslike transitions in the frustrated molecular conductors
θ−(BEDT−TTF)2MM′(SCN)4
Authors: Saito Yohei , Ganter Owen , Shang Chao , Hashimoto Kenichiro , Sasaki Takahiko , Winter Stephen M. , Müller Jens , Lang Michael 
Published: April 2024

We present results of the coefficient of thermal expansion for the frustrated quasi-two-dimensional molecular conductor θ−(BEDT−TTF)2RbZn(SCN)4 for temperatures 1.5≤T≤290 K. A pronounced first-order phase transition anomaly is observed at the combined charge-order/structural transition at 215 K. Furthermore, clear evidence is found for two separate glasslike transitions at Tg=90–100 K and Tg†=120–130 K, similar to previous findings for θ−(BEDT−TTF)2CsZn(SCN)4 and θ−(BEDT−TTF)2CsCo(SCN)4 reported by Thomas [], both of which lack the charge-order/structural transition. Our findings indicate that these glasslike transitions are common features for the θ−(BEDT−TTF)2MM′(SCN)4 family, with M=(Rb, Cs) and M′=(Co, Zn), irrespective of the presence or absence of charge order. These results are consistent with our model calculations on the glasslike dynamics associated with the flexible ethylene end groups of the BEDT-TTF molecules for various θ−(BEDT−TTF)2MM′(SCN)4 salts, predicting two different conformational glass transitions. Moreover, calculations of the hopping integrals show a substantial degree of dependence on the end groups' conformation, suggesting a significant coupling to the electronic degrees of freedom. Our findings support the possibility that the glassy freezing of the ethylene end groups could drive or enhance glassy charge dynamics.

Published by the American Physical Society
2024
The integrated role of adaptive leadership, sense of empathy and communication transparency: trust building in corporate communication during the pandemic
Authors: Meng Juan , Pan Po-Lin , Cacciatore Michael A. , Sanchez Karen Robayo 
Published: March 2024

PurposeThe COVID-19 pandemic has generated a significant impact on several aspects of public relations practice. By adopting the theoretical framework of adaptive leadership, this research is designed to explore how an organization’s top leadership can support related adaptive action in strategic communication. Particularly, we hope to explore whether the application of adaptive leadership could facilitate a higher level of communication transparency as well as deliver a sense of caring and empathy in COVID-19 communication.Design/methodology/approachAn international online survey was designed and conducted for this study. The first sample consists of 776 full-time communication professionals in the United States of America with 435 women (56.1%) and 341 men (43.9%). The second sample consists of 268 full-time communication professionals in Canada, with 110 women (41.0%) and 158 men (59.0%). The two samples were merged into the final sample of 1,044 for the data analysis.FindingsResults confirmed that the perceived impact of the COVID-19 pandemic increased communication professionals’ challenges in building trust. It also drives adaptive changes in their coping actions in strategic communication. More importantly, the top leadership within the organization played a key role in this adaptive leadership environment by demonstrating commitment to transparency in COVID-19 communication and delivering a sense of empathy during the pandemic.Originality/valueThis study contributes to our understanding of strategic communication in times of crisis, such as the COVID-19 global pandemic, by focusing on the adaptive nature of communication leadership. More importantly, our study confirms the important roles of two leadership attributes (i.e. the sense of empathy and the commitment to communication transparency) in supporting adaptive leadership, which eventually influences trust building.
The influence of ITSF on vibration of high voltage Line-Start permanent magnet synchronous motor
Authors: Yang Guanglu , Chen Si , Qiao Jianwei , Liu Yubao , Tian Fuwen , Yang Cunxiang 
Published: April 2024

Purpose
The purpose of this paper is to present the influence of inter-turn short circuit faults (ITSF) on electromagnetic vibration in high-voltage line-starting permanent magnet synchronous motor (HVLSPMSMS).

Design/methodology/approach
In this paper, the ampere–conductor wave model of HVLSPMSM after ITSF is established. Second, a mathematical model of the magnetic field after ITSF is established, and the influence law of the ITSF on the air-gap magnetic field is analyzed. Further, the mathematical expression of the electromagnetic force density is established based on the Maxwell tensor method. The impact of HVLSPMSM torque ripple frequency, radial electromagnetic force spatial–temporal distribution and rotor unbalanced magnetic tension force by ITSF is revealed. Finally, the electromagnetic–mechanical coupling model of HVLSPMSM is established, and the vibration spectra of the motor with different degrees of ITSF are solved by numerical calculation.

Findings
In this study, it is found that the 2np order flux density harmonics and (2 N + 1) p order electromagnetic forces are not generated when ITSF occurs in HVLSPMSM.

Originality/value
By analyzing the multi-harmonics of HVLSPMSM after ITSF, this paper provides a reliable method for troubleshooting from the perspective of vibration and torque fluctuation and rotor unbalanced electromagnetic force.
Workspace in supporting strategy implementation – a study of 25 knowledge-intensive organisations
Authors: Wäistö Pia , Ukko Juhani , Rantala Tero 
Published: April 2024

Purpose
Organisational strategy becomes reality by connecting organisation’s resources and capabilities in daily operations, and physical workspace is one of the environments in which this takes place. This study aims to explore to what extent factors required for successful strategy implementation are considered when designing, using and managing workspaces of knowledge-intensive organisations.

Design/methodology/approach
For the study, managers in 25 large and medium-sized knowledge-intensive organisations were interviewed. The semi-structured interviews focused on organisation’s strategy, strategy implementation practices and workspace design and management. To form a comprehensive framework of strategy implementation success factors for the study, the factors of 11 frameworks were analysed, grouped and renamed.

Findings
Current workspace design, usage and management mainly support human-related strategy implementation factors. However, both organisation- and human-related factors are needed for the strategy implementation to be successful. Therefore, the organisations studied may have unused potential in their workspaces to ensure strategy-aligned operations and behaviour.

Practical implications
Due to the potential imbalance between organisation- and human-related strategy implementation factors, a more holistic, organisational-level approach to workspace design, usage and management is recommended to ensure the success of strategy implementation.

Originality/value
Workspaces have extensively been studied from individual strategy implementation factors’ as well as employees’ perspectives. Prior to this work, there are only few studies exploring workspace in the holistic, strategy implementation context.
Thermal-hydraulic performance of turbulent flows across a heated round tube installed through several perforated twisted tapes
Authors: Perng Shiang-Wuu , Wu Horng Wen , Huang De-An 
Published: April 2024

Purpose
The purpose of this study is to advance turbulent thermal convection inside the constant heat-flux round tube inserted by multiple perforated twisted tapes.

Design/methodology/approach
The novel design of this study is accomplished by inserting several twisted tapes and drilling some circular perforations near the tape edge (C1, C3, C5: solid tapes; C2, C4, C6: perforated tapes). The turbulence flow appearances and thermal convective features are examined for various Reynolds numbers (8,000–14,000) using the renormalization group (RNG)

κ−ε turbulent model and Semi-Implicit Method for Pressure-Linked Equations (SIMPLE) algorithm.

Findings
The simulated outcomes reveal that inserting more perforated-twisted tapes into the heated round tube promotes turbulent thermal convection effectively. A swirling flow caused by the twisted tapes to produce the secondary flow jets between two reverse-spin tapes can combine with the main flow passing through the perforations at the outer edge to enhance the vortex flow. The primary factors are the quantity of twisted tapes and with/without perforations, as the perforation ratio remains at 2.5 in this numerical work. Weighing friction along the tube, C6 (four reverse-spin perforated-twisted tapes) brings the uppermost thermal-hydraulic performance of 1.23 under Re = 8,000.

Research limitations/implications
The constant thermo-hydraulic attributes of liquid water and the steady Newtonian fluid are research limitations for this simulated work.

Practical implications
The simulated outcomes will avail the inner-pipe design of a heat exchanger inserted by multiple perforated twisted tapes to enhance superior heat transfer.

Originality/value
These twisted tapes form tiny circular perforations along the tape edge to introduce the fluid flow through these bores and combine with the secondary flow induced between two reverse-spin tapes. This scheme enhances the swirling flow, turbulence intensity and fluid mixing to advance thermal convection since larger perforations cannot produce large jet velocity or the position of perforations is too far from the tape edge to generate a separated flow. Consequently, this work contributes a valuable cooling mechanism toward thermal engineering.
Evaluation of high quality and full employment based on CRITIC-entropy-TOPSIS multi-criteria framework
Authors: Wei Minyan , Zheng Juntao , Zeng Shouzhen , Jin Yun 
Published: April 2024

PurposeThe main aim of this paper is to establish a reasonable and scientific evaluation index system to assess the high quality and full employment (HQaFE).Design/methodology/approachThis paper uses a novel Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) multi-criteria framework to evaluate the quality and quantity of employment, wherein the integrated weights of attributes are determined by the combined the Criteria Importance Through Inter-criteria Correlation (CRITIC) and entropy approaches.FindingsFirstly, the gap in the Yangtze River Delta in employment quality is narrowing year by year; secondly, employment skills as well as employment supply and demand are the primary indicators that determine the HQaFE; finally, the evaluation scores are clearly hierarchical, in the order of Shanghai, Jiangsu, Zhejiang and Anhui.Originality/valueA scientific and reasonable evaluation index system is constructed. A novel CRITIC-entropy-TOPSIS evaluation is proposed to make the results more objective. Some policy recommendations that can promote the achievement of HQaFE are proposed.
Interruptions at work and (counter)productivity: the mediating role of psychological need unfulfillment
Authors: Lagios Constantin , Blandin Camille , Caesens Gaëtane , Huyghebaert-Zouaghi Tiphaine 
Published: April 2024

Purpose
When employees complete their work tasks, they often experience intrusions stemming from the work (professional intrusions) or the home domain (personal intrusions). Yet, little is known about the respective implications of these two types of intrusions for employees’ productivity. This paper aims to investigate how professional and personal intrusions at work relate to the bright (perceived performance) and dark (procrastination) sides of employees' productivity. Based on recent advances in Self-Determination Theory, the authors also examined the mediating role of psychological need unfulfillment in these relations.

Design/methodology/approach
The authors relied on a cross-sectional survey design. A total of 229 French employees took part in the study.

Findings
Results from structural equation modelling indicated that need unfulfillment mediated the negative association between personal intrusions and employees’ performance and the positive relation between personal intrusions and procrastination. Professional intrusions were positively related to the soldiering dimension of procrastination only.

Originality/value
This study sheds light on the differentiated effects of personal and professional intrusions, while uncovering the psychological mechanisms at play. Personal intrusions, by triggering employees’ need unfulfillment, were found to have more extended detrimental consequences than professional intrusions. To the best of the authors’ knowledge, this research is also the first to demonstrate the mediating role of need unfulfillment in the relations between socio-contextual characteristics and individual functioning, and thus contributes to Self-Determination Theory.