bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meningkatkan kompetensi guru kelas II dalam menyusun perencanaan pembelajaran tematik melalui bimbingan berkelanjutan di wilayah binaan kecamatan Ngadirejo Tahun Pelajaran 2017/2018
Authors: Indriyani Yekti 
Published: March 2024

<p>Abstract. Permasalahan dalam penelitian tindakan sekolah (PTS) ini adalah kompetensi guru kelas II dalam menyusun perencanaan pembelajaran tematik di wilayah binaan kecamatan Ngadirejo masih rendah. Tujuan penelitian ini untuk meningkatkan kompetensi guru kelas II di wilayah binaan kecamatan Ngadirejo tahun pelajaran 2017/2018 melalui bimbingan berkelanjutan. Penelitian Tindakan Sekolah (PTS) termasuk jenis penelitian kuantitatif dengan menggunakan Analisis Deskriptif komparatif dengan membandingkan hasil kondisi awal dengan hasil siklus I teknik kelompok dan hasil siklus II dengan teknik percakapan pribadi.<br />Pada pelaksanaan bimbingan berkelanjutan secara kelompok, hasil penelitian pada siklus I perencanaan pembelajaran tematik yang dibuat oleh guru-guru kelas II masih belum maksimal maka perlu diadakan bimbingan berkelanjutan kembali pada siklus II yaitu pelaksanaan tindakan bimbingan secara individu. Hasil rata-rata kualitas perencanaan pembelajaran tematik pada kondisi awal 44 (kategori kurang). Hasil rata-rata kualitas perencanaan pembelajaran tematik pada siklus I 63,94 (kategori cukup). Peningkatan hasil siklus I dibanding kondisi awal 45,3%. Sedangkan hasil rata-rata kualitas perencanaan pembelajaran tematik pada siklus II 80,37 (kategori Baik). Peningkatan hasil siklus II dibandingkan hasil siklus I sebesar 25,7%.<br />Kata kunci: perencanaan pembelajaran, elementary school</p>
INDONESIAN STUDENTS’ PERSPECTIVES ON ELT IN SHADOW EDUCATION
Authors: Aini S Qurrotul , Putra Kristian Adi 
Published: March 2024

The demand for shadow education in Indonesia is continuously increasing, raising the doubts on the quality of teaching at schools. Therefore, this study aims at analyzing students’ perceptions particularly on English language teaching in shadow education, as compared to those at schools. This study uses semi-structured individual interviews to obtain rich data on students’ experiences and perceptions. The participants were secondary level students who were well-experienced in English shadow education program. The result of this study showed that students’ perception of shadow teaching covered several aspects such as teaching materials, learning outcome, teaching activities, teachers’ teaching performance and learning media. Practically, the students’ perspective towards shadow education had an average of positive experiences. Furthermore, the implications of present study call for a sense of urgency among policy makers and education authorities to consider curricular and methodological overhauling to enhance English teaching efficiency and students’ learning outcomes in line with students’ needs, preferences and concerns in shadow teaching.
Optimization Strategies of Sustainable Urban Land Use Planning Using a Hybridized Technique Based on SWOT-AHP, and GIS in Ibb City, Yemen
Authors: Dammag Abdulkarem Qasem , Jian Dai , Dammag Basema Qasim Derhem 
Published: March 2024

Abstract

The high rate of population growth led to migration from rural to urban settlements, causing unregulated growth, urban sprawls, and inefficiencies in city planning of developing countries. yet, in regions like Yemen, rapid urbanization poses significant challenges for urban planners. Addressing these challenges, this study proposes an innovative approach to urban planning in the context of Ibb City, Yemen, a region grappling with rapid urbanization and inefficient land use. The study identifies a significant gap in the integration of strategic planning and technological tools in developing urban areas. The study utilized SWOT technology to examine the internal and external factors, the AHP method to prioritize the factors to make them measurable, and GIS geospatial zonal analysis. This integrated approach provides a comprehensive evaluation of internal and external factors affecting urban land use, with a focus on quantifying priorities for sustainable urban development. The study's results offer a detailed assessment of the social, economic, infrastructure, and environmental aspects of Ibb City, highlighting the interaction between these elements in urban planning. Importantly, the findings extend beyond the local context, presenting a scalable and adaptable model for urban planning, particularly in developing countries with similar urban dynamics. The study underscores the critical role of strategic, data-driven planning in fostering sustainable urban environments, offering significant insights and tools for policymakers and urban planners for sustainable urban growth.
Reversible downregulation of MYC in a spheroid model of metastatic epithelial ovarian cancer
Authors: Shepherd Trevor , Buensuceso Adrian , Borrelli Matthew , Valdes Yudith Ramos 
Published: March 2024

Abstract

Upon detachment from the primary tumour, epithelial ovarian cancer cells can form multicellular aggregates, also referred to as spheroids, that have the capacity to establish metastases at distant sites. These structures exhibit numerous adaptations that may facilitate metastatic transit and promote tumorigenic potential. One such adaptation is the acquisition of dormancy, characterized by decreased proliferation and molecular features of quiescence. One of the most frequently dysregulated genes in cancer is MYC, which encodes a transcription factor that promotes cell proliferation. In this study, we demonstrate that MYC protein abundance and associated gene expression is significantly decreased in EOC spheroids compared to adherent cells. This downregulation occurs rapidly upon cell detachment and is proteasome-dependent. Moreover, MYC protein abundance and associated gene expression is restored upon spheroid reattachment to an adherent culture surface. Overall, our findings suggest that suppression of MYC activity is a common feature of EOC spheroids and may contribute to the reversible acquisition of dormancy.
Outcome of induction and associated factors among induced laboring mother at Dessie Comprehensive specialized Hospital, Dessie, Ethiopia.
Authors: LIMENIH ABEL SHIFERAW , KIDANEMARIAM AKEBOM , DURESSA ABDI DINGETA 
Published: March 2024

Abstract
Background
Induction of labor refers to iatrogenic stimulation of uterine contractions before the onset of spontaneous labor to accomplish vaginal delivery. It is a common obstetric procedure performed during pregnancy and is thought to be associated with greater maternal or fetal risk. Although the induction of labor is commonly practiced, its outcomes and associated factors are rarely assessed in our settings. Therefore, this study aimed to fill this gap by studying the outcomes of labor induction and associated factors among women who delivered at the Dessie Compressive Specialized Hospital.
Objective
The objective of this study was to assess the outcome induction of labor and associated factors among induced laboring mothers at the Dessie Compressive Specialized Hospital from March 1, 2023 to June 30, 2023.
Methods
An institution-based cross-sectional study was conducted on 308 study participants from March 1, 2023 to June 30, 2023. Data were collected through daily patient interviews and chart reviews of the individual mothers for additional information. Study participants were recruited using a consecutive sampling method. Data were entered using Epi-Data Version 4.6 and analyzed using SPSS Version 25. A bivariate logistic regression model was used to identify factors affecting the outcome of labor induction. Variables with P-values less than 0.25 in the bivariate analysis were entered into the multivariate analysis. Odds ratios (ORs) with 95% confidence intervals (CI) were used to assess association strength. Statistical significance was set at P < 0.05.
Results
The results of the study revealed that, out of 308 total cases of labor induction, 232(75.32%; 95% CI = 70–80) of them achieved successful labor induction. A favorable Bishop Score (AOR = 16.46, 95% CI = 7.685–35.283), multigravida (AOR = 5.17, 95% CI = 2.293–11.657), rural resident (AOR = 3.0393, 95% CI = 1.270–7.5730), and ripening by misoprostol (AOR = 5.203, 95% CI = 1.834–14.763) were significantly associated with successful labor induction.
Conclusion
The proportion of successful induction of labor was moderate in the study area. Favorable Bishop Score, Multigravida, ripening by misoprostol, and rural residency are the main determinants. It may be necessary to conduct case-control or cohort studies to further investigate factors that increase the likelihood of failed induction.
Prenatal immune activation in mice induces long-term alterations in brain mitochondrial function.
Authors: Gasser Edith Schneider , Schaer Ron , Mueller Flavia , Bernhardt Alexandra , Lin Han-Yu , Arias-Reyes Christian , Weber-Stadlbauer Ulrike 
Published: March 2024

Abstract
Prenatal exposure to infections is a risk factor for neurodevelopmental disorders in offspring, and alterations in mitochondrial function are discussed as a potential underlying factor. Here, using a mouse model of viral-like maternal immune activation based on poly(I:C) (POL) treatment at gestational day (GD) 12, we show that adult offspring exhibit behavioral deficits, such as reduced levels of social interaction. In addition, we found increased NADH- and succinate-linked mitochondrial respiration and maximal electron transfer capacity in the prefrontal cortex (PFC) and in the amygdala (AMY) of males and females. The increase in respiratory capacity resulted from an increase in mitochondrial mass in neurons (as measured by complex IV activity and transcript expression), presumably to compensate for a reduction in mitochondrion-specific respiration. Moreover, in the PFC of control (CON) male offspring a higher excess capacity compared to females was observed, which was significantly reduced in the POL-exposed male offspring, and, along with a higher leak respiration, resulted in a lower mitochondrial coupling efficiency. Transcript expression of the uncoupling proteins (UCP4 and UCP5) showed a reduction in the PFC of POL male mice, suggesting mitochondrial dysfunction. In addition, in the PFC of CON females, a higher expression of the antioxidant enzyme superoxide dismutase (SOD1) was observed, suggesting a higher antioxidant capacity as compared to males. Finally, transcripts analysis of genes involved in mitochondrial biogenesis and dynamics showed reduced expression of fission/fusion transcripts in PFC of POL offspring of both sexes. In conclusion, we show that MIA causes alterations in neuronal mitochondrial function and mass in the PFC and AMY of adult offspring with some effects differing between males and females.
Optimization scheduling of microgrid comprehensive demand response load considering user satisfaction
Authors: Wang Chaoliang , Li Xiong 
Published: March 2024

Abstract
Flexible load control of microgrid based on demand-side management not only improves energy efficiency of the supply side of microgrid, but also considers the overall willingness to users. Regarding the limitations of the current microgrid demand response model, this paper further optimizes the flexible load control strategy and proposes a two-objective optimization model based on price and incentive. Meanwhile, the model is solved using an improved chaotic particle group algorithm. Finally, the microgrid load data were selected for simulation analysis. The simulation results showed that the comprehensive demand response of flexible control model proposed increased the overall satisfaction of users by 9.51%, the overall operating cost of microgrid suppliers decreased by 12.9752/ ten thousand yuan, the peak valley difference decreased by 4.61%, and the user demand response increased by 27.24%. The model effectively improves the overall profit of the supply side of the microgrid, improves the user satisfaction, and maximizes the linkage benefits of the supply and demand of the micro grid.
Evaluation of Water Ecological Security of Mountain City Based on the Frame of “Water-Soil, Water-City, and Water-Net”
Authors: Liu Yali , Lu Tao , Liu Fang , Zhang Zhen , Yan Jingjing , Wu Fangfang 
Published: March 2024

Abstract
By using the concept of Territorial Spatial Planning, this paper constructed the framework of water ecological security evaluation of territorial space in mountain cities, based on the perspectives of Macro-, Medium- and Micro-, and the 3 levels of “Water-soil, Water-city, Water-net”. Establish the method of water ecological security evaluation of territorial space in mountainous city with “3 levels, 4 characteristics, 6 dimensions and 12 actions”, by combining the 3 basic disciplines of “ecology, environment and security”, focusing on the 3 core functions of ”water-soil conservation, water-city integration, water-net linkage”, to the target of the 4 requirements of “ecological civilization, environmental friendliness, security and resilience, mountain application”, concentrating on the 6 spatial dimensions of “Source- Shelter -City-Shore-Net-Flow”, revolving around the 12 major water actions “Water conservation, Water maintenance, Water protection, Water restoration; Water identification, Water management, Water Connectivity, Water control; Water mediation, Water guidance, Water cycle, Water treatment”. Through an empirical study in typical mountain city, fill up the blank of Territorial Spatial Water Ecological Security Evaluation of mountain city, and provide basic method guidance and key technical support for the integrated development of mountain city with high quality.
Differential Association of Abdominal, Liver and Epicardial Adiposity with Anthropometry and Cardiac Remodeling in Asians
Authors: Chin Calvin , Lee Vivian , Han Yiying , Toh Desiree-Faye , Bryant Jennifer , Boubertakh Redha , Le Thu-Thao 
Published: March 2024

Abstract

Background
Heterogenous deposition and homeostasis roles of physiologic and ectopic adipose tissues underscore the implication of fat compartmentalization on cardiometabolic risk. We aimed to characterize the distribution of abdominal visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), epicardial adipose tissue (EAT) and liver fat on magnetic resonance imaging (MRI), and evaluate their associations with anthropometric indices and adverse cardiac remodeling.
Methods
In this cross-sectional observational study, all 149 Asian adults (57.0±12.8 years; 65% males) with at least one cardiometabolic risk factor underwent fat and cardiovascular MRI. Anthropometric indices included body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR) and bioimpedance body fat mass (BFM).
Results
We observed opposing associations of VAT and SAT with liver fat and EAT, therefore VAT/SAT ratio was explored as an integrated marker of visceral adiposity. VAT/SAT was associated with EAT (β=0.35, P<0.001) and liver fat (β=0.32, P=0.002) independent of confounders. Of the anthropometric measures assessed, only WHR was independently associated with VAT/SAT (β=0.16, P=0.03). Individuals with T2DM had higher VAT and lower SAT compared to those without T2DM, translating to a significantly higher VAT/SAT ratio. Independent association was observed between greater EAT volume and adverse features of cardiac remodeling: increased left ventricular mass (β=0.24, P=0.005), larger myocyte volume (β=0.25, P=0.002), increased myocardial fibrosis (β=0.19, P=0.032), higher concentricity (β=0.18, P=0.035) and elevated wall stress (β=−0.18, P=0.023).
Conclusions
VAT/SAT ratio is a promising marker for multiorgan visceral fat composition T2DM. EAT is uniquely associated with adverse cardiac remodeling, suggesting distinctive cardiometabolic properties from other fat depots.
TPMS-based auxetic structure for high-performance airless tires with variable stiffness depending on deformation
Authors: Kim Do-Yeon , Kim Hong-Seok , Kamath Sarath , Hou Xiangying , Choi Jae-Won , Park Sang-Hu 
Published: March 2024

Abstract

A novel auxetic structure applicable to airless tire spokes is designed based on the primitive-type triply periodic minimal surface (P-TPMS) to have higher stiffness through deformation under compressive force. For becoming higher stiffness by deformation, an unit cell of auxetic structure is proposed and its characteristics according to design parameters are studied. Based on the parametric study, a rotated primitive-type auxetic structure (RPAS) is designed, and the deformative behaviors of an airless tire with the RPAS spokes are compared with a generally used honeycomb spoke. Simulation and experiment results show that the designed RPAS tire exhibits more stable behavior through higher rigidity depending on the deformation state when compressed on flat ground and obstacles. This variable stiffness characteristic of RPAS tires can be advantageous for shock absorption and prevention of large local deformations. Also, the manufacturability of the designed auxetic structure is evaluated using real rubber-based additive manufacturing processes for practical application in the tire manufacturing industry.
Effect of the COVID-19 on Patients with Systemic Lupus Erythematosus during the First Pandemic Wave in China
Authors: Wu Pengjia , Liu Xiaoxia , Li Na , Fan Youyang , Liu Jun , Qin Longyan , Yang Lei , Zhang Aifei , Zeng Jiashun 
Published: March 2024

Abstract
Objective: This study aimed to investigate the prevalence and clinical manifestations of coronavirus disease (COVID-19) in patients with systemic lupus erythematosus (SLE) during the first wave of the pandemic in China and to evaluate the effects of COVID-19 on the disease activity and treatment of SLE.
Methods: A telephone survey was conducted on patients diagnosed with SLE in our hospital between October 2017 and October 2022. Through the survey, we investigated whether the patients had COVID-19, the clinical manifestations of the infection, whether the patients were vaccinated, the effects of the infection on the disease activity of SLE, and whether the treatment regimen for SLE was adjusted due to the infection.
Results: A total of 351 patients participated in this study, of whom 261 (74.4%) had COVID-19. Regarding organ involvement, the circulatory system was more commonly affected than the other organs in patients with SLE without COVID-19 (P = 0.002). Regarding concomitant medications, the daily dose of glucocorticoids was higher than that of other medication in SLE patients without COVID-19 (P = 0.000). No differences were observed in age, disease duration, disease activity, of other concomitant medications. While infected with COVID-19, 46 patients (17.6%) discontinued parts of their treatment without experiencing any episodes of SLE.
Conclusion: Most SLE patients with COVID-19 had a good prognosis, and all the patients in our study recovered from COVID-19 infection. Abrupt dose reduction and discontinuation of medications by the patients themselves may lead to elevated disease activity or even episodes of SLE. As such, it is recommended that the patients adjust their treatment regimens following the guidance of their specialists after careful evaluation of their condition and SLE disease activity by specialists.
RETRACTED: Genesis of sulfide hosted invisible gold mineralization within the Vempalle dolostone of Korivipalle area, Cuddapah Supergroup, southern India.
Authors: Behera Ramesh Chandra , Singh Sahendra , Srivast Shalivahan , Barla Anmol , Dash Mahimaa 
Published: March 2024

Abstract

The authors have requested that this preprint be removed from Research Square.
Identification and verification of immune-related genes for diagnosing the progression of atherosclerosis and metabolic syndrome
Authors: Xie Qian , Zhang Xuehe , Liu Fen , Luo Junyi , Liu Chang , Zhang Zhiyang , Yang Yining , Li Xiaomei 
Published: March 2024

Abstract

Background
Atherosclerosis and metabolic syndrome are the main causes of cardiovascular events, but their underlying mechanisms are not clear. In this study, we focused on identifying genes associated with diagnostic biomarkers and effective therapeutic targets associated with these two diseases.
Methods
Transcriptional data sets of atherosclerosis and metabolic syndrome were obtained from GEO database. The differentially expressed genes were analyzed by RSTUDIO software, and the function-rich and protein-protein interactions of the common differentially expressed genes were analyzed.
Results
A total of 1242 differential genes (778 up-regulated genes and 464 down-regulated genes) were screened from GSE28829 data set. A total of 1021 differential genes (492 up-regulated genes and 529 down-regulated genes) were screened from the data set GSE98895.Then 23 up-regulated genes and 11 down-regulated genes were screened by VENN diagram.Functional enrichment analysis showed that cytokines and immune activation were involved in the occurrence and development of these two diseases.Through the construction of PPI network and Cytoscape software analysis, we finally screened 10 HUB genes.The immune infiltration analysis was further improved. The results showed that the infiltration scores of 7 kinds of immune cells in GSE28829 were significantly different among groups (Wilcoxon Test < 0.05), while in GSE98895, the infiltration scores of 4 kinds of immune cells were significantly different between groups (Wilcoxon Test < 0.05).Spearman method was used to analyze the correlation between the expression of 10 key genes and 22 kinds of immune cell infiltration scores in two data sets.The results showed that there were 42 pairs of significant correlations between 10 genes and 22 kinds of immune cells in GSE28829 (| Cor | > 0.3 & P < 0.05).There were 41 pairs of significant correlations between 10 genes and 22 kinds of immune cells in GSE98895 (| Cor | > 0.3 & P < 0.05).Finally, our results identified 10 small molecules with the highest absolute enrichment value, and the three most significant key genes (CX3CR1, TLR5, IL32) were further verified in the data expression matrix and clinical blood samples.
Conclusion
We have established a co-expression network between atherosclerotic progression and metabolic syndrome, and identified key genes between the two diseases. this may be helpful to provide new research ideas for the diagnosis and treatment of atherosclerosis complicated with metabolic syndrome.