bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of the Solvent and the Nucleophile on the Photochemical Synthesis of Azepines
Authors: Giricheva Marina A. , Budruev Andrei V. 
Published: April 2024

AbstractThe research focused on the photolysis of ortho‐ and para‐substituted aryl azides and the preparation of 2‐arylamino‐substituted azepines. The best results were achieved in 1,4‐dioxane for ortho‐substituted azides and in ethanol for para‐substituted azides, respectively. It was found that reactions with arylamines, which have electron‐donating groups, typically produce higher yields of heterocycles than those with electron‐withdrawing groups.
Asymmetric Allylation of Aldoxime Derivatives with β‐Amidoallylboronate in Water and Its Application to Divergent Synthesis of N‐Hydroxy‐γ‐Lactam and 1,2‐Oxazinan‐6‐one
Authors: Sengoku Tetsuya , Anze Wataru , Hasegawa Naoya , Mizutani Yuta , Kubota Asahi , Inuzuka Toshiyasu , Yoda Hidemi 
Published: April 2024

AbstractA new application involving a water–stable amido–functionalized allylboronate has been developed for 1,2‐addition to carbon–nitrogen double bonds. The process achieves highly enantioselective allylation of aldoxime derivatives in water, by employing O‐Boc oximes as substrates under Zn(OH)2–chiral aminophenol catalysis. This process affords the corresponding homoallylic amines with 91–96 % ee. The products could be transformed into N‐hydroxy‐γ‐lactam or 1,2‐oxazinan‐6‐one, through an acidic or a protection‐acidic treatment sequence, respectively, almost without enantiopurity loss.
Design, Synthesis and In Silico Molecular Docking Evaluation of New Series of 1,2,3‐Triazole Derivatives as Potent Antimicrobial Agents
Authors: Vellaiyan Venkatesan , Nagarajaiah Honnappa , Shaik Adamshafi , Kishore Pilli V. V. N , Gunda Shravan Kumar 
Published: April 2024

AbstractChalcone and triazole scaffolds have demonstrated a crucial role in the advancement of science and technology. Due to their significance, research has proceeded on the design and development of novel benzooxepine connected to 1,2,3‐triazolyl chalcone structures. The new chalcone derivatives produced by benzooxepine triazole methyl ketone and different aromatic carbonyl compounds. Product structures were established by various spectral techniques such as IR, 1H NMR, 13C NMR, and mass specrometric analysis. Among the tested compounds, two compounds exhibited exceptional antibacterial susceptibilities with MIC (Minimum inhibitory concentration) range of 3.59–10.30 μM against the tested S. aureus strain. Few of the compounds displayed superior antifungal activity against F. oxysporum with MIC value range from 3.25‐4.89 μM, when compared to fluconazole (MIC=3.83 μM). In addition, few derivatives demonstrated equivalent antitubercular action against H37Rv strain with MIC range of 2.16–4.90 μM. The capacity of one of the ligand to form a stable compound on the active site of CYP51 from M. tuberculosis (1EA1) was confirmed by docking studies. Additionally, the chalcone‐1,2,3‐triazole hybrids ADME (absorption, distribution, metabolism, and excretion), molecular characteristics, estimation of toxicity, and bioactivity scores were assessed.
Chitosan‐nTiO2 Nanocomposite Synthesis and its Adsorptive Removal Capacity for Methylene Blue from its Aqueous Solution: Batch Adsorption Study and Modeling
Authors: Bhattacharya Samanwita , Bar Nirjhar , Rajbansi Baisali , Das Sudip Kumar 
Published: April 2024

AbstractThe current work used chitosan (CS)‐nTiO2 nanocomposites (CTNCs) prepared with different CS:nTiO2 mass ratios toward the MB dye removal from an aqueous medium in batch method at variable experimental conditions. The stability and competence of the nanocomposites were checked through characterization by SEM, FTIR, XRD, TGA, and BET. The highest removal of MB was 78 % with the adsorbent CS without nTiO2 (CWT), 94.5 % with CS:nTiO2=1 : 1 weight ratio (CTNC1‐1) and 80 % with CS:nTiO2=2 : 1 weight ratio (CTNC2‐1) with 10 mgL−1of MB and 5 gL−1 adsorbent dosages. The experimental observations obeyed the pseudo‐2nd‐order model, and rate‐limiting steps were film diffusions for CWT, CTNC1‐1 and intraparticle diffusion for CTNC2‐1. Monolayer adsorption was established from the isotherm model. Langmuir adsorption capacities for MB were presented as CTNC1‐1 (qL=34.31)>CTNC2‐1 (qL=32.87)>CWT (qL=21.32). The sorption energy, as derived from Dubinin–Radushkevich isotherm model, showed physisorption for all three adsorbents. The scale‐up design is reported. The statistical (R2>0.98) and GA modeling (R2>0.98) successfully predicted the percentage elimination of MB. Thus, CS‐nTiO2 nanocomposites are prepared as novel and environment‐friendly adsorbents for dye removal.
Experimental study on viscoelastic damper with amplified mechanism and seismic mitigation evaluation
Authors: Xu Hao , Jia Sufan , Shang Feng , He Wenfu 
Published: April 2024

SummaryIn this study, a viscoelastic damper (VED) employing an additional amplification device is proposed to enhance the stiffness as well as energy dissipation. The mechanical model of the amplified viscoelastic damper (AVED) is developed and the amplification efficiency is explored. The mechanical behaviors of AVED and the traditional VED are experimentally investigated. By adopting a leverage system, the stiffness and the dissipated energy of AVED are significantly improved and the amplification factors are confirmed. Meanwhile, the seismic responses and structural damages are addressed through a numerical study on a frame attached to the AVEDs and VEDs. The AVED reinforced building employing fewer dampers has close seismic responses compared with VED reinforced building. Furthermore, the installation of AVEDs significantly reduces the risk of structural damage.
Postnatal outcome following fetal aortic valvuloplasty for critical aortic stenosis
Authors: Corroenne R. , Meot M. , Salomon L. J. , Szezepanski I. , Baghdadi H. , Stos B. , Levy M. , Le Bidois J. , Laux D. , Gaudin R. , Raisky O. , Ville Y. , Bonnet D. , Stirnemann J. , Malekzadeh‐Milani S. 
Published: April 2024

ABSTRACTObjectiveTo report our experience of fetal aortic valvuloplasty (FAV) for critical aortic stenosis (AS), with a focus on the postnatal evolution of the patients.MethodsThis was a retrospective study including all fetuses with critical AS which underwent FAV in a single center between January 2011 and June 2022. FAV was performed under ultrasound guidance. Technical success was based upon balloon inflation across the aortic valve and improvement of the antegrade aortic flow across the aortic valve. At birth, a biventricular circulation (BVC) strategy was decided assuming the left ventricular (LV) systolic and diastolic function would ensure the systemic circulation.ResultsSixty‐three FAV procedures were performed in 58 fetuses, at a median (range) gestational age of 26.2 (20.3–32.2) weeks. The procedure was technically successful in 50/58 (86.2%) fetuses. There were 11/58 (19.0%) cases of in‐utero demise and 9/58 (15.5%) terminations of pregnancy. No patient was liveborn after an unsuccessful procedure. Thirty‐eight (65.5%) infants were liveborn, at a median (range) gestational age of 38.1 (29.0–40.6) weeks, of whom 21 (55.3%) required prostaglandin treatment. Twenty‐eight of the 38 (73.7%) liveborn children (48.3% of the study population) entered the BVC pathway at birth. Among them, 20 (71.4%) required an aortic valvuloplasty procedure at birth (11 (55.0%) percutaneous balloon, nine (45.0%) surgical) and eight (28.6%) did not require any treatment at birth, but, of these, five (62.5%) underwent surgical valvuloplasty between day 26 and day 1200 of age. Eleven (39.3%) of the infants with BVC at birth required a second intervention and four (14.3%) of them required a third intervention. Two (7.1%) infants who entered the BVC pathway at birth underwent conversion to univentricular circulation (UVC). None of the surviving children with BVC developed pulmonary hypertension. The overall survival rate in those with BVC at birth was 22/28 (78.6%) at a median (range) follow‐up of 23.3 (2.0–112.6) months. Ten of the 58 (17.2%) patients had UVC at birth. Among these, six (60.0%) received compassionate care from birth and four (40.0%) underwent surgery. Three of the 10 patients who had UVC at birth were still alive at the latest follow‐up assessment, at a median (range) gestational age of 24.3 (8.3–48.7) months.ConclusionsFAV for critical AS led to increase of antegrade aortic flow in 86.2% of fetuses, with BVC being achieved in 48.3% (73.7% of the liveborn cases). Among patients with BVC at birth, the rate of reintervention was high, but 78.6% of these children were alive at the latest evaluation. © 2024 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Postoperative pancreatic fistula after pancreaticogastrostomy versus pancreatojejunostomy after pancreatic resection, a comparative systematic review and meta‐analysis
Authors: Salman Mohamed AbdAlla , Elewa Ahmed , Elsherbiny Mohammed , Tourkey Mohamed , Emechap Evelyn Nkem , Chikukuza Stewart , Salman Ahmed 
Published: April 2024

AbstractBackgroundIn patients undergoing pancreaticoduodenectomy (PD), there has been some evidence favoring pancreaticogastrostomy (PG) over pancreatojejunostomy (PJ) in the occurrence of postoperative pancreatic fistulas (POPF) and considering PG as a safer anastomotic technique. However, other publications revealed comparable incidences of POPF attributed to both techniques. The current work attempts to reach a more consolidated conclusion about such an issue.MethodsThis is a systematic review and meta‐analysis that analyzed the studies comparing PG and PJ during PD in terms of the rate of POPF occurrence. Studies were obtained by searching the Scopus, PubMed Central, and Cochrane Central Register of Controlled Trials databases.Results35 articles published between 1995 and 2022 presented data from 14,666 patients; 4547 underwent PG and 10,119 underwent PJ. Statistically significant lower rates of POPF (p = 0.044) and clinically relevant CR‐POPF (p = 0.043) were shown in the PG group. The post‐pancreatectomy hemorrhage (PPH) was significantly higher in the PG group, while no significant difference was found between the two groups in the clinically significant PPH. No statistically significant differences were found regarding the amount of intraoperative blood loss, length of hospital stay, DGE, overall morbidity rates, reoperation rates, or mortality rates. The percentage of male sex in the PG group and the percentage of soft pancreas in the PJ group seem to influence the odds ratio of CR‐POPF (p = 0.076 and 0.074, respectively).ConclusionThe present study emphasizes the superiority of PG over PJ regarding CR‐POPF rates. Higher rates of postoperative hemorrhage were associated with PG. Yet, the clinically significant hemorrhage rate was comparable between the two groups.
Synthesis, Structure, and Reactivity of a Superbulky low‐Valent β‐diketiminate Ga(I) Complex
Authors: Richter Tim , Thum Stefan , Townrow Oliver P. E. , Wiesinger Michael , Langer Jens , Harder Sjoerd 
Published: April 2024

AbstractA low‐valent GaI complex with the superbulky β‐diketiminate ligand DIPePBDI (HC[C(Me)N−DIPeP]2, DIPeP=2,6‐C(H)Et2‐phenyl)) was obtained by reduction of (DIPePBDI)GaI2 (1) with KC8 in toluene. Considering that (BDI)GaI and analogue (BDI)AlI complexes are prone to decomposition and can generally only be obtained in low yields (20–40 %), the quantitative formation of (DIPePBDI)GaI (2) is remarkable and no doubt related to its excellent thermal stability even in refluxing toluene. Although the low‐valent metal center in 2 is sterically protected by the superbulky DIPePBDI ligand, it is readily oxidized by N2O to give intermediate (DIPePBDI)Ga=O which readily decomposed by abstracting a proton from the backbone Me‐substituent. Reaction with trimethylsilyl azide gave an intermediate imido complex (DIPePBDI)Ga=N(SiMe3)2 which reacted with a second equivalent of Me3SiN3 to a mixture of an azide/amido complex (DIPePBDI)GaN3[N(SiMe3)2] (4) and a tetrazagallole complex (DIPePBDI)Ga[N4(SiMe3)2] (5) in a 1 : 2 ratio. Whereas the azide/amido complex 4 could be structurally characterised, the tetraazagallole complex 5 was identified by NMR spectroscopy. DFT calculations on (DIPePBDI)GaI (2) and its reaction products complement this study.
Shock and Stress
Authors: Hughes David A. 
Published: April 2024

AbstractEver since it became clear that victims of shell shock in World War I displayed increased psychological malleability, social engineers have sought to exploit the application of shock and stress for social control purposes. Experiments on POWs and other test subjects in the 1950s showed that it was possible to “depattern” the human mind and to reprogramme behaviour. The Tavistock Institute, which took control of the mental health profession after 1945, weaponised psychiatry and found ways of applying shock and stress techniques to entire societies, facilitating what Naomi Klein calls the “shock doctrine,” i.e. systematic exploitation of public disorientation following a moment of collective shock. The “lockdowns” in 2020 were a shock and awe operation, and other techniques associated with “depatterning” the mind were additionally deployed, including disruption of behavioural patterns, isolation, and defamiliarisation. The moment of shock was used to implant trigger words and images for purposes of trauma-based mind control.
Trauma-based Mind Control
Authors: Hughes David A. 
Published: April 2024

AbstractIncreasing evidence has come to light of trauma-based mind control exercises performed on children in ritual abuse settings. Those exercises involve torture, near death experiences, and making victims feel responsible for the death of others. The traumatised child is made to feel completely powerless and dependent on the abuser for their survival. Highly disturbingly, similar techniques—involving psychological torture, intentional traumatization, and false rescue—were carried out against the public during “Covid-19.” Psychological torture techniques include the inculcation of chronic stress and the mandatory wearing of face masks (originally deployed against inmates at Guantánamo Bay). The public was traumatised by fear of death from the “virus” and was made to feel responsible for the deaths of others. A trauma bonding was instigated, intended to last decades and to bind an infantilised population in loyalty and obedience to its “omnipotent” masters. Predatory transnational power came to the false rescue in exchange for the surrendering of liberties.
Mass Paranoia and Hysteria: Turning Society Against Itself
Authors: Hughes David A. 
Published: April 2024

AbstractIn keeping with totalitarianism, Covid-era psychological warfare worked to turn people against one another, to prevent them from uniting against their oppressors. Mass paranoia was inculcated through the lie that “anyone can spread it.” Guilt was weaponised to blame and shame those not following the “rules” and “protecting others.” Mask mandates segregated society. Dissenters were scapegoated. A new form of hate speech was introduced: “anti-maskers,” “anti-vaxxers,” etc. Members of the public were encouraged to police one another. The public was primed for violence against dissenters misleadingly framed as “fringe.” The “pandemic of the unvaccinated” myth styled the outgroup as vectors of disease, like Jews in Nazi propaganda. The “vaccinated” were turned on the “unvaccinated” through mechanisms of blame, medicalised apartheid, incitement of hatred by the media, and lies that hospitals were filling up with “unvaccinated” patients. Society is now deeply divided between those who can see through psychological operations and those who cannot.
The Coming Unrest
Authors: Hughes David A. 
Published: April 2024

AbstractThe transnational ruling class has no choice but to keep pushing for global technocracy, and the rest of humanity has no choice but to fight back. Knowing since 1968 at least that this moment was coming, the former has developed the CIA’s information-liquidation model used in Indonesia and Vietnam in the 1960s into a global digital surveillance dragnet. The “Covid-19 vaccines,” shot into as many people as possible for no sound medical reason, could form part of an advanced weapons system, not least in the context of the emergent “IT/Bio/Nano era” envisaged by NASA in 2001, involving the use of nanotechnologies to connect human beings to an external network. If the brain is the twenty-first-century battlescape, and given that syringe-injectable neural nets were a reality by 2018, the evil potential of weaponised neurotechnology knows no bounds. History teaches that as the old social order breaks down, a moment of revolutionary potential arises. Lest unimaginable horrors be allowed to manifest, as in previous world wars, that moment must be seized.
The Stages of the Comic Book Co-creation and the Restitution to the Chiquitano Indigenous People
Authors: Parola Giulia , Poto Margherita Paola , Natividad Gabrielle 
Published: April 2024

AbstractThis chapter delves into the analysis of the methodological steps of the co-created process involved in producing a comic book, following the steps outlined in Chapter 2. Extensive research material, outlined at the end of the book, was utilized throughout the project in conjunction with co-creation stages and legal research. The project focuses on the Chiquitano people from Mato Grosso, Brazil, specifically the community in Vila Nova Barbecho, due to their precarious environmental situation and human rights violations.
The Comic Book
Authors: Parola Giulia , Poto Margherita Paola ,   in coordination with Flávia Fernandes, Luiz Fernando Giesta, Aline França, Marcela Aguiar, Giselle Cardoso, Adriana Molina, Beatriz Storino, Mariana Pauzeiro, Loyuá Costa, Igor Kall, Caroline Macel, Silvano Chue Muquissai
Published: April 2024

AbstractThis chapter contains the comic book, realised following the methodological steps analysed in the previous chapters. The participants in the comic format close the book.
The Shaping of Municipal Policies on Inclusion
Authors: Spencer Sarah , Ataç Ilker , Bastick Zach , Homberger Adrienne , Güntner Simon , Kirchhoff Maren , Mallet-Garcia Marie 
Published: April 2024

AbstractThis chapter contextualises recent developments at municipal level in Europe and the ways in which these have been addressed in the research literature. The chapter sets out the national policy frameworks within which local authorities must navigate their approach to precarious migrants and summarises the state of play on inclusion. A key theme is the contrast between national and municipal approaches, and the paradox of simultaneous policies of formal exclusion and formal inclusion, within and between each tier of governance. The chapter considers the significance of multi-level and horizontal governance arrangements; of municipal framing of rationales for service provision; the range of actors involved in delivering services; and the factors which shape service access and exclusion, including data ‘firewalls’. The chapter identifies gaps in the existing evidence and analysis which are addressed in the book.
Conclusion
Authors: Spencer Sarah , Ataç Ilker , Bastick Zach , Homberger Adrienne , Güntner Simon , Kirchhoff Maren , Mallet-Garcia Marie 
Published: April 2024

AbstractIn this chapter we remind the reader of the core questions that the study set out to address and summarise the key findings and themes which emerged and which are set out in the book. We make further observations, reflecting back to questions arising from the research literature and identify some issues for a future research agenda before setting out a series of policy recommendations for municipalities across Europe as well as for national, regional and European authorities.
PLD2 deletion ameliorates sepsis-induced cardiomyopathy by suppressing cardiomyocyte pyroptosis via the NLRP3/caspase 1/GSDMD pathway
Authors: Li Jun , Teng Da , Jia Wenjuan , Gong Lei , Dong Haibin , Wang Chunxiao , Zhang Lihui , Xu Bowen , Wang Wenlong , Zhong Lin , Wang Jianxun , Yang Jun 
Published: April 2024

Abstract
Objective
Sepsis-induced cardiomyopathy (SICM) is a life-threatening complication. Phospholipase D2 (PLD2) is crucial in mediating inflammatory reactions and is associated with the prognosis of patients with sepsis. Whether PLD2 is involved in the pathophysiology of SICM remains unknown. This study aimed to investigate the effect of PLD2 knockout on SICM and to explore potential mechanisms.

Methods
The SICM model was established using cecal ligation and puncture in wild-type and PLD2-knockout mice and lipopolysaccharide (LPS)-induced H9C2 cardiomyocytes. Transfection with PLD2-shRNA lentivirus and a PLD2 overexpression plasmid were used to interfere with PLD2 expression in H9C2 cells. Cardiac pathological alterations, cardiac function, markers of myocardial injury, and inflammatory factors were used to evaluate the SICM model. The expression of pyroptosis-related proteins (NLRP3, cleaved caspase 1, and GSDMD-N) was assessed using western blotting, immunofluorescence, and immunohistochemistry.

Results
SICM mice had myocardial tissue damage, increased inflammatory response, and impaired heart function, accompanied by elevated PLD2 expression. PLD2 deletion improved cardiac histological changes, mitigated cTNI production, and enhanced the survival of the SICM mice. Compared with controls, PLD2-knockdown H9C2 exhibits a decrease in inflammatory markers and lactate dehydrogenase production, and scanning electron microscopy results suggest that pyroptosis may be involved. The overexpression of PLD2 increased the expression of NLRP3 in cardiomyocytes. In addition, PLD2 deletion decreased the expression of pyroptosis-related proteins in SICM mice and LPS-induced H9C2 cells.

Conclusion
PLD2 deletion is involved in SICM pathogenesis and is associated with the inhibition of the myocardial inflammatory response and pyroptosis through the NLRP3/caspase 1/GSDMD pathway.
The impact of nanomaterials on autophagy across health and disease conditions
Authors: Florance Ida , Cordani Marco , Pashootan Parya , Moosavi Mohammad Amin , Zarrabi Ali , Chandrasekaran Natarajan 
Published: April 2024

AbstractAutophagy, a catabolic process integral to cellular homeostasis, is constitutively active under physiological and stress conditions. The role of autophagy as a cellular defense response becomes particularly evident upon exposure to nanomaterials (NMs), especially environmental nanoparticles (NPs) and nanoplastics (nPs). This has positioned autophagy modulation at the forefront of nanotechnology-based therapeutic interventions. While NMs can exploit autophagy to enhance therapeutic outcomes, they can also trigger it as a pro-survival response against NP-induced toxicity. Conversely, a heightened autophagy response may also lead to regulated cell death (RCD), in particular autophagic cell death, upon NP exposure. Thus, the relationship between NMs and autophagy exhibits a dual nature with therapeutic and environmental interventions. Recognizing and decoding these intricate patterns are essential for pioneering next-generation autophagy-regulating NMs. This review delves into the present-day therapeutic potential of autophagy-modulating NMs, shedding light on their status in clinical trials, intervention of autophagy in the therapeutic applications of NMs, discusses the potency of autophagy for application as early indicator of NM toxicity.
Graphical Abstract