bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can Alveolar Bone Grafting Using Posterior Iliac Crest be a Day Surgery Procedure?
Authors: Varidel Alistair , Ambrose Maria , DiTullio Nancy , Fritschy Taylor , Padwa Bonnie L. , Resnick Cory M. 
Published: March 2024

Objective The purpose of this study was to determine if patients undergoing alveolar bone grafting (ABG) can be discharged home on the day of surgery safely and with high satisfaction. Design This is a prospective cohort study of patients who underwent ABG over a 6-month period (August 2022 to February 2023). Medical records were reviewed, and postoperative surveys were provided to assess patient/family experience. Setting Tertiary care free-standing pediatric hospital. Patients and Participants Participants who had ABG using iliac marrow from the posterior iliac crest. Interventions Subjects were assigned to overnight admission (ON) or day surgery (DS) based on hospital bed capacity. Main Outcome Measures Main outcome measures were postoperative medical events and satisfaction with discharge timing. Results 41 participants were included: ON, n = 20 (48.8%); DS, n = 21 (51.2%), and there were no differences between groups in any predictor variable. There were no postoperative medical events. Overall, families reported comfort managing pain, nausea, bleeding, hydration, and nutrition after discharge. Most (83.3% of the DS group and 69.2% of the ON group, P = .644) reported satisfaction with the discharge timing they received, despite this being driven by hospital rather than patient factors. Reasons for some families preferring longer admission included fluid management (n = 2), anxiety about postoperative swelling (n = 2), and a long drive home (n = 1). For the ON group, 16.7% would have preferred same-day discharge. Conclusions Same day discharge is safe and well-received in appropriately selected patients who undergo ABG using posterior iliac crest. Perioperative patient/family education is essential.
Differences in Baseline Physical Function and Mental Health PROM Scores in Patients With Foot and Ankle Conditions
Authors: Smith Jeremy T. , Parker Emily B. , Bluman Eric M. , Martin Elizabeth A. , Chiodo Christopher P. 
Published: March 2024

Background:This study sought to establish normative values for baseline physical and mental health by foot and ankle diagnosis using validated PROMIS scores and to compare the correlation between these 2 outcomes across common diagnoses. Additionally, it investigated the effects associated with chronic vs acute conditions and specific diagnoses on mental health.Methods:We reviewed baseline PROMIS Physical Function 10a (PF10a) and PROMIS Global-Mental (PGM) scores of 14,245 patients with one of the 10 most common foot and ankle diagnoses seen at our institution between 2016 and 2021. Pearson correlation coefficients were calculated to assess the relationship between PF10a and PGM by diagnosis. A multivariable regression model including age, sex, language, race, ethnicity, education level, income, and Charlson Comorbidity Index was used to determine the associated effect of diagnosis on PGM score.Results:On unadjusted analysis, patients diagnosed with an ankle fracture had the lowest mean physical function, whereas patients with hallux valgus had the highest (PF10a = 33.9 vs 46.7, P < .001). Patients with foot/ankle osteoarthritis had the lowest mean self-reported mental health, whereas patients with hallux rigidus had the highest (PGM = 49.9 vs 53.4, P < .001). PF10a and PGM scores were significantly positively correlated for all diagnoses; the correlation was strongest in patients diagnosed with foot/ankle osteoarthritis or hammertoes ( r = 0.511) and weakest in patients with ankle fractures ( r = 0.232) or sprains ( r = 0.280). Chronic conditions, including hammertoes (β = −5.1, 95% CI [−5.8, −4.3], P < .001), foot/ankle osteoarthritis (β = −5.0, 95% CI [−5.7, −4.3], P < .001), and hallux valgus (β = −4.8, 95% CI [−5.5, −4.1], P < .001) were associated with the largest negative effects on patients’ mental health.Conclusion:Self-reported physical function and mental health varied across common foot and ankle diagnoses and were more tightly correlated in chronic conditions. The associations between diagnosis and mental health scores appear larger for more chronic diagnoses, including those that are generally associated with relatively unimpaired physical function.
Clinical characteristics and outcomes of patients operated for primary hyperparathyroidism at Tampere University Hospital in 2017–2018
Authors: Tamski Jussi , Hakala Tommi , Huhtala Heini , Metso Saara 
Published: March 2024

Background and objective: Studies on the outcomes of parathyroid surgery are scarce. The aim was to report the outcomes and to study the association between pre- and peri-operative information with the outcomes of patients operated for primary hyperparathyroidism. Methods: This was a retrospective, descriptive study with unselected patients treated surgically for primary hyperparathyroidism from a catchment population of 704,500 in Finland. Data were acquired from the electronic hospital registers based on parathyroid surgery procedure codes between 1 January 2017 and 31 December 2018. Preoperative data, surgical data, preoperative and postoperative laboratory values, histopathological findings, and postoperative clinical data were recorded. Results: During the 2-year study period, 149 patients with primary hyperparathyroidism were treated surgically with a 97% remission rate. Surgical complications included postoperative bleeding in two patients (1%) and vocal cord paralysis in one patient (0.6%). No postoperative infections were reported. Three patients (2%) developed postoperative hypoparathyroidism necessitating the use of alfacalcidol more than 1 month after surgery. Ionized calcium measured 0–1 days after surgery was not statistically significantly associated with remission or postoperative hypoparathyroidism. Serum parathyroid hormone (PTH) assessed 0–1 days postoperatively was associated with persistent disease, but not with postoperative hypoparathyroidism. The histopathological diagnosis was adenoma or hyperplasia in 112 patients (75%), atypical adenoma in 28 patients (19%), and carcinoma in five patients (3%). Patients with parathyroid carcinoma had higher preoperative ionized calcium and PTH values than those with adenoma or hyperplasia. Conclusions: Most patients who were operated due to primary hyperparathyroidism achieved normocalcemia after surgery, and the frequency of complications was low. Ionized calcium taken 0–1 days after surgery was not associated with remission of hyperparathyroidism or postoperative hypoparathyroidism. High postoperative serum PTH predicted persistent disease.
Prevalence and nature of bullying in schoolchildren aged 10–14 years and its association with malocclusion: A cross-sectional study in the South East of the UK
Authors: DiBiase Andrew , Cox Zaffie , Rea Michaela , Gonidis Lazaros , Cameron Lindsey , Rutland Adam 
Published: March 2024

Objective: To investigate the prevalence of, and relationship between, bullying and malocclusion in schoolchildren aged 10–14 years in the South East of the UK. Design: Cross-sectional cohort study. Setting: Sixteen primary and secondary schools in South East of the UK. Participants: Schoolchildren aged 10–14 years who were consented to participate. Methods: The prevalence and nature of bullying were measured using a questionnaire. Traits of malocclusion and the need for orthodontic treatment were assessed by clinical examination and determined by the Index of Orthodontic Treatment Need (IOTN) Dental Health (DHC) and Aesthetic components (AC). Results: Complete data were collected for 698 participants. The number defined as being bullied was 68 (9.7%). There was no difference in the prevalence of bullying between gender, ethnicity or age. Higher rates of bullying were reported in mixed sex schools ( P = 0.03). Participants with an increased overjet ( P = 0.02) and/or a greater need for treatment, as measured by IOTN DHC ( P = 0.01) and AC ( P = 0.01), reported higher rates of bullying. While there was no difference in the overall prevalence of bullying between genders, boys were more likely than girls to experience physical bullying ( P <0.001) and being called names ( P = 0.03) Conclusion: A significant relationship was evident between being bullied and certain traits of malocclusion.
Injury to the Main Branch of the Saphenous Nerve following Hamstring Tendon Graft Harvesting: A Report of 3 Cases
Authors: Flaherty Alexandra , Escalera Cristian , Haeberle Heather , Fealy Stephen , Lee Steve K. 
Published: March 2024

Background: Hamstring tendon grafts are commonly utilized tendon autografts; however, the harvesting procedure can result in saphenous nerve injury due to its proximity to the semitendinosus and gracilis tendons. Injury to the main branch of the saphenous nerve is a less commonly reported and understood injury during these procedures. Purpose: This case report aimed to identify and present cases of iatrogenic injury to the main branch of the saphenous nerve during hamstring tendon graft harvesting. Methods: A retrospective chart review of a tertiary-care hospital over the past 10 years was conducted. The search included clinical notes mentioning “saphenous neuropathy, neuralgia or neuritis” and magnetic resonance imaging (MRI) reports indicating saphenous nerve involvement. Patients with a history of a hamstring graft harvesting procedure and radiographically confirmed injury to the main branch of the saphenous nerve were included. Injury characteristics, symptoms, and sequential treatment were evaluated. Results: Three cases of iatrogenic injury to the main branch of the saphenous nerve during hamstring graft harvesting were identified. Reported symptoms included pain, paresthesia, numbness, hypersensitivity, swelling, and discoloration. All 3 patients had persistent symptoms despite non-operative treatment and therefore underwent surgical intervention, which involved resection and reconstruction using allograft or burial into adjacent musculature. Postoperatively, 2 of 3 patients demonstrated resolution of symptoms. Conclusion: Iatrogenic injury to the main branch of the saphenous nerve is a complication that can occur during hamstring tendon harvesting procedures, leading to severe, persistent symptoms. A better understanding of the mechanism of injury is needed to minimize the risk of iatrogenic injury.
Sex Differences in Quadriceps Atrophy After Anterior Cruciate Ligament Tear
Authors: Owen Meredith K. , Casadonte Kelsey R. , Thomas Nicholas T. , Latham Christine M. , Brightwell Camille R. , Thompson Katherine L. , Hawk Gregory S. , Jacobs Cale A. , Johnson Darren L. , Fry Christopher S. , Noehren Brian 
Published: March 2024

Background: Female athletes lag behind their male counterparts in recovery from anterior cruciate ligament (ACL) injury. Quadriceps muscle size and strength are crucial factors for regaining function after ACL injury, but little is known about how these metrics vary due to biological sex. Hypothesis: Female patients have reduced vastus lateralis fiber cross-sectional area (CSA) and lower quadriceps strength after ACL injury than male patients. Study Design: Cross-sectional study. Level of Evidence: Level 4. Methods: A total of 60 participants with recent ACL tear were evaluated for vastus lateralis muscle fiber CSA, isometric quadriceps peak torque, and quadriceps rate of torque development. Linear mixed models were fit to determine differences across sex and limb for each variable of interest. Results: The female group averaged almost 20% atrophy between limbs ( P < 0.01), while the male group averaged just under 4% ( P = 0.05). Strength deficits between limbs were comparable between female and male groups. Conclusion: Immediately after ACL injury, female patients have greater between-limb differences in muscle fiber CSA but between-limb strength deficits comparable with those of male patients. Clinical Relevance: These results indicate that the underpinnings of strength loss differ based on biological sex, and thus individual patients could benefit from a sex-specific treatment approach to ACL injury.
Targeting the TNF/IAP pathway synergizes with anti-CD3 immunotherapy in T-cell acute lymphoblastic leukemia
Authors: Ávila Ávila Andrea , Nuantang Kanokporn , Oliveira Mariana L. , Druillennec Sabine , Zaniboni Benedetta , Lengliné Etienne , Asnafi Vahid , Ghysdael Jacques , Tran Quang Christine 
Published: March 2024

Abstract
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy. Current treatments, based on intensive chemotherapy regimens provide overall survival rates of ∼85% in children and &lt;50% in adults, calling the search of new therapeutic options. We previously reported that targeting the T-cell receptor (TCR) in T-ALL with anti-CD3 (αCD3) monoclonal antibodies (mAbs) enforces a molecular program akin to thymic negative selection, a major developmental checkpoint in normal T-cell development; induces leukemic cell death; and impairs leukemia progression to ultimately improve host survival. However, αCD3 monotherapy resulted in relapse. To find out actionable targets able to re-enforce leukemic cells’ vulnerability to αCD3 mAbs, including the clinically relevant teplizumab, we identified the molecular program induced by αCD3 mAbs in patient-derived xenografts derived from T-ALL cases. Using large-scale transcriptomic analysis, we found prominent expression of tumor necrosis factor α (TNFα), lymphotoxin α (LTα), and multiple components of the “TNFα via NF-κB signaling” pathway in anti-CD3–treated T-ALL. We show in vivo that etanercept, a sink for TNFα/LTα, enhances αCD3 antileukemic properties, indicating that TNF/TNF receptor (TNFR) survival pathways interferes with TCR-induced leukemic cell death. However, suppression of TNF-mediated survival and switch to TNFR-mediated cell death through inhibition of cellular inhibitor of apoptosis protein-1/2 (cIAP1/2) with the second mitochondrial-derived activator of caspases (SMAC) mimetic birinapant synergizes with αCD3 to impair leukemia expansion in a receptor-interacting serine/threonine-protein kinase 1–dependent manner and improve mice survival. Thus, our results advocate the use of either TNFα/LTα inhibitors, or birinapant/other SMAC mimetics to improve anti-CD3 immunotherapy in T-ALL.
Cryo-EM structure and functional basis of prothrombin recognition by a type I antiprothrombin antiphospholipid antibody
Authors: Kumar Suresh , Summers Brock , Basore Kathrine , Pengo Vittorio , Flaumenhaft Robert , Pozzi Nicola 
Published: March 2024

Abstract
Antiprothrombin antibodies are found in antiphospholipid patients, but how they interact with prothrombin remains elusive. Prothrombin adopts closed and open forms. We recently discovered type I and type II antibodies and proposed that type I recognizes the open form. In this study, we report the discovery and structural and functional characterization in human plasma of a type I antibody, POmAb (prothrombin open monoclonal antibody). Using surface plasmon resonance and single-molecule spectroscopy, we show that POmAb interacts with kringle-1 of prothrombin, shifting the equilibrium toward the open form. Using single-particle cryogenic electron microscopy (cryo-EM), we establish that the epitope targeted by POmAb is in kringle-1, comprising an extended binding interface centered at residues R90-Y93. The 3.2-Å cryo-EM structure of the complex reveals that the epitope overlaps with the position occupied by the protease domain of prothrombin in the closed state, explaining the exclusive binding of POmAb to the open form. In human plasma, POmAb prolongs phospholipid-initiated and diluted Russell’s viper venom clotting time, which could be partly rescued by excess phospholipids, indicating POmAb is an anticoagulant but exerts a weak lupus anticoagulant effect. These studies reveal the structural basis of prothrombin recognition by a type I antiphospholipid antibody and uncover an exciting new strategy to achieve anticoagulation in human plasma.
Integrated Active Suspension and Anti-Lock Braking Control for Four-Wheel-Independent-Drive Electric Vehicles
Authors: Zhao Ze , Zhang Lei , Ding Xiaoling , Zhang Zhiqiang , Li Shaohua , Gu Liang 
Published: March 2024

AbstractThis paper presents an integrated control scheme for enhancing the ride comfort and handling performance of a four-wheel-independent-drive electric vehicle through the coordination of active suspension system (ASS) and anti-lock braking system (ABS). First, a longitudinal-vertical coupled vehicle dynamics model is established by integrating a road input model. Then the coupling mechanisms between longitudinal and vertical vehicle dynamics are analyzed. An ASS-ABS integrated control system is proposed, utilizing an H∞ controller for ASS to optimize load transfer effect and a neural network sliding mode control for ABS implementation. Finally, the effectiveness of the proposed control scheme is evaluated through comprehensive tests conducted on a hardware-in-loop (HIL) test platform. The HIL test results demonstrate that the proposed control scheme can significantly improve the braking performance and ride comfort compared to conventional ABS control methods.
High-efficiency flexible organic solar cells with a polymer-incorporated pseudo-planar heterojunction
Authors: Zhang Lin , He Yuxin , Deng Wen , Guo Xueliang , Bi Zhaozhao , Zeng Jie , Huang Hui , Zhang Guangye , Xie Chen , Zhang Yong , Hu Xiaotian , Ma Wei , Yuan Yongbo , Yuan Xiaoming 
Published: March 2024

AbstractOrganic solar cells (OSCs) are considered as a crucial energy source for flexible and wearable electronics. Pseudo-planar heterojunction (PPHJ) OSCs simplify the solution preparation and morphology control. However, non-halogenated solvent-printed PPHJ often have an undesirable vertical component distribution and insufficient donor/acceptor interfaces. Additionally, the inherent brittleness of non-fullerene small molecule acceptors (NFSMAs) in PPHJ leads to poor flexibility, and the NFSMAs solution shows inadequate viscosity during the printing of acceptor layer. Herein, we propose a novel approach termed polymer-incorporated pseudo-planar heterojunction (PiPPHJ), wherein a small amount of polymer donor is introduced into the NFSMAs layer. Our findings demonstrate that the incorporation of polymer increases the viscosity of acceptor solution, thereby improving the blade-coating processability and overall film quality. Simultaneously, this strategy effectively modulates the vertical component distribution, resulting in more donor/acceptor interfaces and an improved power conversion efficiency of 17.26%. Furthermore, PiPPHJ-based films exhibit superior tensile properties, with a crack onset strain of 12.0%, surpassing PPHJ-based films (9.6%). Consequently, large-area (1 cm2) flexible devices achieve a considerable efficiency of 13.30% and maintain excellent mechanical flexibility with 82% of the initial efficiency after 1000 bending cycles. These findings underscore the significant potential of PiPPHJ-based OSCs in flexible and wearable electronics.
Conducting head-mounted eye-tracking research with young children with autism and children with increased likelihood of later autism diagnosis
Authors: Perkovich E. , Laakman A. , Mire S. , Yoshida H. 
Published: March 2024

Abstract
Background
Over the past years, researchers have been using head-mounted eye-tracking systems to study young children’s gaze behaviors in everyday activities through which children learn about the world. This method has great potential to further our understanding of how millisecond-level gaze behaviors create multisensory experiences and fluctuate around social environments. While this line of work can yield insight into early perceptual experiences and potential learning mechanisms, the majority of the work is exclusively conducted with typically-developing children. Sensory sensitivities, social-communication difficulties, and challenging behaviors (e.g., disruption, elopement) are common among children with developmental disorders, and they may represent potential methodological challenges for collecting high-quality data.

Results
In this paper, we describe our research practices of using head-mounted eye trackers with 41 autistic children and 17 children with increased likelihood of later autism diagnosis without auditory or visual impairments, including those who are minimally or nonspeaking and/or have intellectual disabilities. The success rate in gathering data among children with autism was 92.68%. 3 of 41 children failed to complete the play-session, resulting in an 86.36% success rate among 1–4-year-olds and a 100.00% success rate among 5–8-year-olds. 1 of 17 children with increased likelihood of later autism diagnosis failed to complete the play-session, resulting in a success rate of 94.11%. There were numerous “challenging” behaviors relevant to the method. The most common challenging behaviors included taking the eye-tracking device off, elopement, and becoming distressed. Overall, among children with autism, 88.8% of 1–4-year-olds and 29.4% of 5–8-year-olds exhibited at least one challenging behavior.

Conclusions
Research capitalizing on this methodology has the potential to reveal early, socially-mediated gaze behaviors that are relevant for autism screening, diagnosis, and intervention purposes. We hope that our efforts in documenting our study methodology will help researchers and clinicians effectively study early naturally-occuring gaze behaviors of children during non-experimental contexts across the spectrum and other developmental disabilities using head-mounted eye-tracking. Ultimately, such applications may increase the generalizability of results, better reflect the diversity of individual characteristics, and offer new ways in which this method can contribute to the field.
Molecular characterization of recombinant LSDV isolates from 2022 outbreak in Indonesia through phylogenetic networks and whole-genome SNP-based analysis
Authors: Sendow Indrawati , Meki Irene Kasindi , Dharmayanti Ni Luh Putu Indi , Hoerudin Heri , Ratnawati Atik , Settypalli Tirumala Bharani K. , Ahmed Hatem Ouled , Nuradji Harimurti , Saepulloh Muharam , Adji Rahmat Setya , Fairusya Nuha , Sari Faralinda , Anindita Katamtama , Cattoli Giovanni , Lamien Charles Euloge 
Published: March 2024

AbstractLumpy skin disease (LSD) is a transboundary viral disease of cattle and water buffaloes caused by the LSD virus, leading to high morbidity, low mortality, and a significant economic impact. Initially endemic to Africa only, LSD has spread to the Middle East, Europe, and Asia in the past decade. The most effective control strategy for LSD is the vaccination of cattle with live-attenuated LSDV vaccines. Consequently, the emergence of two groups of LSDV strains in Asian countries, one closely related to the ancient Kenyan LSDV isolates and the second made of recombinant viruses with a backbone of Neethling-vaccine and field isolates, emphasized the need for constant molecular surveillance. This current study investigated the first outbreak of LSD in Indonesia in 2022. Molecular characterization of the isolate circulating in the country based on selected LSDV-marker genes: RPO30, GPCR, EEV glycoprotein gene, and B22R, as well as whole genome analysis using several analytical tools, indicated the Indonesia LSDV isolate as a recombinant of LSDV_Neethling_vaccine_LW_1959 and LSDV_NI-2490. The analysis clustered the Indonesia_LSDV with the previously reported LSDV recombinants circulating in East and Southeast Asia, but different from the recombinant viruses in Russia and the field isolates in South-Asian countries. Additionally, this study has demonstrated alternative accurate ways of LSDV whole genome analysis and clustering of isolates, including the recombinants, instead of whole-genome phylogenetic tree analysis. These data will strengthen our understanding of the pathogens’ origin, the extent of their spread, and determination of suitable control measures required.