bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meaning Holism andDe ReAscription
Authors: Whiting Daniel 
Published: February 2009

According to inferential role semantics (IRS), for an expression to have a particular meaning or express a certain concept is for subjects to be disposed to make, or to treat as proper, certain inferential transitions involving that expression. Such a theory of meaning isholistic, since according to it the meaning or concept any given expression possesses or expresses depends on the inferential relations it stands in to other expressions.It is widely recognised that this holism leads to twoprima facieproblems for IRS. First, since no two speakers share the same beliefs, they will inevitably be disposed to make, or treat as correct,differentinferential transitions involving an expression. Hence, according to IRS, the same word in different mouths will possess a different meaning and be understood in different ways. It seems to follow thatcommunicationis impossible.
Predicting adult health and mortality from adolescent facial characteristics in yearbook photographs
Authors: Reither Eric N. , Hauser Robert M. , Swallen Karen C. 
Published: February 2009

Abstract
Several important longitudinal studies in the social sciences have omitted biomarkers that are routinely recorded today, including height and weight. To account for this shortcoming in the Wisconsin Longitudinal Study (WLS), an 11-point scale was developed to code high school senior class yearbook photographs of WLS participants for relative body mass (RBM). Our analyses show that although imperfect, the RBM scale is reliable (α = .91) and meets several criteria of validity as a measure of body mass. Measured at ages 17–18, the standardized relative body mass index (SRBMI) was moderately correlated (r = .31) with body mass index (BMI) at ages 53–54 and with maximum BMI reported between ages 16 and 30 (r = .48). Overweight adolescents (≥ 90th percentile of SRBMI) were about three times more likely than healthy-weight adolescents (10th–80th percentile of SRBMI) to be obese in adulthood and, as a likely consequence, significantly more likely to report health problems such as chest pain and diabetes. Overweight adolescents also suffered a twofold risk of premature death from all nonaccidental causes as well as a fourfold risk of heart disease mortality. The RBM scale has removed a serious obstacle to obesity research and lifelong analyses of health in the WLS. We suggest that other longitudinal studies may also be able to obtain photos of participants at younger ages and thus gain a prospectively useful substitute for direct measures of body mass.
Marriage behavior response to prime-age adult mortality: evidence from malawi
Authors: Ueyama Mika , Yamauchi Futoshi 
Published: February 2009

Abstract
This article examines the effect of AIDS-related mortality of the prime-age adult population on marriage behavior among women in Malawi. A rise in prime-age adult mortality increases risks associated with the search for a marriage partner in the marriage market. A possible behavioral change in the marriage market in response to an increase in prime-age adult mortality is to marry earlier to avoid exposure to HIV/AIDS risks. We test this hypothesis by using micro data from Malawi, where prime-age adult mortality has drastically increased. In the analysis, we estimate the probability of prime-age adult mortality that sample women have observed during their adolescent period by utilizing retrospective information on deaths of their siblings. Empirical analysis shows that excess prime-age adult mortality in the local marriage market lowers the marriage age for females and shortens the interval between the first sex and first marriage.
The rising share of nonmarital births: is it only compositional effects?
Authors: Ermisch John 
Published: February 2009

Abstract
A recent article by Gray, Stockard, and Stone contended that the increase in the proportion of births to unmarried women since 1974 in the United States was not caused by any major change in underlying fertility behavior, but rather by a decrease in the proportion of women who are married, which increased both the population at risk and the birth rate of unmarried women relative to that of married women. In this comment, I argue that the statistical test of this explanation used in the article is invalid because the variables in the analysis are not stationary time series. Correct statistical tests reject the explanation. In particular, I demonstrate persistent, nonstationary deviations from the relationships predicted by the theory advanced by Gray et al. For long periods, the proportion unmarried played only a small role in the changes in the ratio of nonmarital to marital birth rates, contrary to the theory.
Bayesian estimation of hispanic fertility hazards from survey and population data*
Authors: Rendall Michael S. , Handcock Mark S. , Jonsson Stefan H. 
Published: February 2009

Abstract
Previous studies have demonstrated both large gains in efficiency and reductions in bias by incorporating population information in regression estimation with sample survey data. These studies, however, assumed that the population values are exact. This assumption is relaxed here through a Bayesian extension of constrained maximum likelihood estimation applied to U.S. Hispanic fertility. The Bayesian approach allows for the use of both auxiliary survey data and expert judgment in making adjustments to published Hispanic Population fertility rates, and for the estimation of uncertainty about these adjustments. Compared with estimation from sample survey data only, the Bayesian constrained estimator results in much greater precision in the age pattern of the baseline fertility hazard and therefore of the predicted values for any given combination of socioeconomic variables. The use of population data in combination with survey data may therefore be highly advantageous even when the population data are known to have significant levels of nonsampling error.
Comment: there may be compositional effects, but they do not work that way*
Authors: Martin Steven 
Published: February 2009

Abstract
This analysis joins the debate on how declines in marriage have shifted the composition of the unmarried and married populations in the United States, and how compositional shifts have affected nonmarital birth rates. Gray, Stockard, and Stone (2006) presented one model for compositional effects that Ermisch (2009) challenged with alternative statistical tests. I propose an alternative model for compositional shifts based not on theory but on observed marriage and fertility patterns. The results from this alternative model are consistent with Ermisch’s findings yet support Gray et al.’s general case that compositional effects have had an important infiuence on nonmarital birth rates.
Family boundary ambiguity and the measurement of family structure: the significance of cohabitation
Authors: Brown Susan L. , Manning Wendy D. 
Published: February 2009

AbstractWe used data from the first wave of the National Longitudinal Study of Adolescent Health to examine family boundary ambiguity in adolescent and mother reports of family structure and found that the greater the family complexity, the more likely adolescent and mother reports of family structure were discrepant. This boundary ambiguity in reporting was most pronounced for cohabiting stepfamilies. Among mothers who reported living with a cohabiting partner, only one-third of their teenage children also reported residing in a cohabiting stepfamily. Conversely, for those adolescents who reported their family structure as a cohabiting stepfamily, just two-thirds of their mothers agreed. Levels of agreement between adolescents and mothers about residing in a two-biological-parent family, single-mother family, or married stepfamily were considerably higher. Estimates of the distribution of adolescents across family structures vary according to whether adolescent, mother, or combined reports are used. Moreover, the relationship between family structure and family processes differed depending on whose reports of family structure were used, and boundary ambiguity was associated with several key family processes. Family boundary ambiguity presents an important measurement challenge for family scholars.
Composition and decomposition in nonmarital fertility
Authors: Wu Lawrence l. 
Published: February 2009

Abstract
Ermisch (2009) criticized Gray, Stockard, and Stone (2006), arguing that they incorrectly tested a model positing a nonlinear relationship between the nonmarital fertility ratio and the proportion of unmarried women. I identify a different problem, which is that even if this model were to hold for a particular population, it would not in general hold for subgroups of this population; likewise, were it to hold for subgroups, it would not hold for aggregations of these subgroups.
Birds of a feather, or friend of a friend? using exponential random graph models to investigate adolescent social networks
Authors: Goodreau Steven M. , Kitts James A. , Morris Martina 
Published: February 2009

AbstractIn this article, we use newly developed statistical methods to examine the generative processes that give rise to widespread patterns in friendship networks. The methods incorporate both traditional demographic measures on individuals (age, sex, and race) and network measures for structural processes operating on individual, dyadic, and triadic levels. We apply the methods to adolescent friendship networks in 59 U.S. schools from the National Longitudinal Survey of Adolescent Health (Add Health). We model friendship formation as a selection process constrained by individuals’ sociality (propensity to make friends), selective mixing in dyads (friendships within race, grade, or sex categories are differentially likely relative to cross-category friendships), and closure in triads (a friend’s friends are more likely to become friends), given local population composition. Blacks are generally the most cohesive racial category, although when whites are in the minority, they display stronger selective mixing than do blacks when blacks are in the minority. Hispanics exhibit disassortative selective mixing under certain circumstances; in other cases, they exhibit assortative mixing but lack the higher-order cohesion common in other groups. Grade levels are always highly cohesive, while females form triangles more than males. We conclude with a discussion of how network analysis may contribute to our understanding of sociodemographic structure and the processes that create it.
Response to Ermisch, Martin, and Wu
Authors: Gray Jo Anna , Stockard Jean , Stone Joe 
Published: February 2009

Abstract
Our recent paper in Demography (Gray, Stockard, and Stone 2006) has attracted the close scrutiny of several prominent academics. Three sets of formal comments, authored independently by Ermisch, Martin, and Wu (EMW), appear in this issue of Demography. In this response we argue that the analysis and evidence of our 2006 paper have withstood the scrutiny of EMW. In particular, we find that a substantial part of the rising share of nonmarital births since 1970 is due to a selection effect associated with marriage. This same selection effect also explains how birth rates could rise in both groups, even though their combined birth rate did not. In sum, though we appreciate the opportunity to expand on several key aspects of our 2006 article, we see no reason to substantially revise any of our major conclusions based on the EMW comments.
Fleeing the storm(s): an examination of evacuation behavior during florida’s 2004 hurricane season
Authors: Smith Stanley K. , McCarty Chris 
Published: February 2009

AbstractThe 2004 hurricane season was the worst in Florida’s history, with four hurricanes causing at least 47 deaths and some $45 billion in damages. To collect information on the demographic impact of those hurricanes, we surveyed households throughout the state and in the local areas that sustained the greatest damage. We estimate that one-quarter of Florida’s population evacuated prior to at least one hurricane; in some areas, well over one-half of the residents evacuated at least once, and many evacuated several times. Most evacuees stayed with family or friends and were away from home for only a few days. Using logistic regression analysis, we found that the strength of the hurricane and the vulnerability of the housing unit had the greatest impact on evacuation behavior; additionally, several demographic variables had significant effects on the probability of evacuating and the choice of evacuation lodging (family/friends, public shelters, or hotels/motels). With continued population growth in coastal areas and the apparent increase in hurricane activity caused by global warming, threats posed by hurricanes are rising in the United States and throughout the world. We believe the present study will help government officials plan more effectively for future hurricane evacuations.
Height and the normal distribution: evidence from italian military data
Authors: A’hearn Brian , Peracchi Franco , Vecchi Giovanni 
Published: February 2009

AbstractResearchers modeling historical heights have typically relied on the restrictive assumption of a normal distribution, only the mean of which is affected by age, income, nutrition, disease, and similar influences. To avoid these restrictive assumptions, we develop a new semiparametric approach in which covariates are allowed to affect the entire distribution without imposing any parametric shape. We apply our method to a new database of height distributions for Italian provinces, drawn from conscription records, of unprecedented length and geographical disaggregation. Our method allows us to standardize distributions to a single age and calculate moments of the distribution that are comparable through time. Our method also allows us to generate counterfactual distributions for a range of ages, from which we derive age-height profiles. These profiles reveal how the adolescent growth spurt (AGS) distorts the distribution of stature, and they document the earlier and earlier onset of the AGS as living conditions improved over the second half of the nineteenth century. Our new estimates of provincial mean height also reveal a previously unnoticed “regime switch” from regional convergence to divergence in this period.
European External Quality Control Study on the Competence of Laboratories to Recognize Rare Sequence Variants Resulting in Unusual Genotyping Results
Authors: Márki-Zay János , Klein Christoph L , Gancberg David , Schimmel Heinz G , Dux László 
Published: February 2009

AbstractBackground: Depending on the method used, rare sequence variants adjacent to the single nucleotide polymorphism (SNP) of interest may cause unusual or erroneous genotyping results. Because such rare variants are known for many genes commonly tested in diagnostic laboratories, we organized a proficiency study to assess their influence on the accuracy of reported laboratory results.Methods: Four external quality control materials were processed and sent to 283 laboratories through 3 EQA organizers for analysis of the prothrombin 20210G&gt;A mutation. Two of these quality control materials contained sequence variants introduced by site-directed mutagenesis.Results: One hundred eighty-nine laboratories participated in the study. When samples gave a usual result with the method applied, the error rate was 5.1%. Detailed analysis showed that more than 70% of the failures were reported from only 9 laboratories. Allele-specific amplification-based PCR had a much higher error rate than other methods (18.3% vs 2.9%). The variants 20209C&gt;T and [20175T&gt;G; 20179_20180delAC] resulted in unusual genotyping results in 67 and 85 laboratories, respectively. Eighty-three (54.6%) of these unusual results were not recognized, 32 (21.1%) were attributed to technical issues, and only 37 (24.3%) were recognized as another sequence variant.Conclusions: Our findings revealed that some of the participating laboratories were not able to recognize and correctly interpret unusual genotyping results caused by rare SNPs. Our study indicates that the majority of the failures could be avoided by improved training and careful selection and validation of the methods applied.
Analytical Ancestry: “Firsts” in Fluorescent Labeling of Nucleosides, Nucleotides, and Nucleic Acids
Authors: Kricka Larry J , Fortina Paolo 
Published: February 2009

AbstractBackground: The inherent fluorescent properties of nucleosides, nucleotides, and nucleic acids are limited, and thus the need has arisen for fluorescent labeling of these molecules for a variety of analytical applications.Content: This review traces the analytical ancestry of fluorescent labeling of nucleosides, nucleotides, and nucleic acids, with an emphasis on the first to publish or patent. The scope of labeling includes (a) direct labeling by covalent labeling of nucleic acids with a fluorescent label or noncovalent binding or intercalation of a fluorescent dye to nucleic acids and (b) indirect labeling via covalent attachment of a secondary label to a nucleic acid, and then binding this to a fluorescently labeled ligand binder. An alternative indirect strategy involves binding of a nucleic acid to a nucleic acid binder molecule (e.g., antibody, antibiotic, histone, antibody, nuclease) that is labeled with a fluorophore. Fluorescent labels for nucleic acids include organic fluorescent dyes, metal chelates, carbon nanotubes, quantum dots, gold particles, and fluorescent minerals.Summary: Fluorescently labeled nucleosides, nucleotides, and nucleic acids are important types of reagents for biological assay methods and underpin current methods of chromosome analysis, gel staining, DNA sequencing and quantitative PCR. Although these methods use predominantly organic fluorophores, new types of particulate fluorophores in the form of nanoparticles, nanorods, and nanotubes may provide the basis of a new generation of fluorescent labels and nucleic acid detection methods.
A Multiplex Assay for Detecting Genetic Variations in CYP2C9, VKORC1, and GGCX Involved in Warfarin Metabolism
Authors: Rai Alex J , Udar Nitin , Saad Rana , Fleisher Martin 
Published: February 2009

Abstract
Background: Patients differ in responses to warfarin, which is commonly prescribed to treat thromboembolic events. Genetic variations in the cytochrome P450, family 2, subfamily C, polypeptide 9 (CYP2C9), vitamin K epoxide reductase complex, subunit 1 (VKORC1), and gamma-glutamyl carboxylase (GGCX) genes have been shown to contribute to impaired metabolism of warfarin.
Methods: We designed a custom multiplex single-nucleotide polymorphism (SNP) panel to interrogate the CYP2C9 *2, *3, VKORC1 (–1639G→A), and GGCX (1181T→G) alleles simultaneously in a single sample by use of single-base extension and capillary electrophoresis after genomic DNA extraction and PCR amplification.
Results: Our assay successfully detected various genotypes from known controls and 24 unknown samples. It was found to be 100% concordant with sequencing results.
Conclusions: Our multiplexed SNP panel can be successfully used in genotyping of patient blood samples. Results can be combined with other clinical parameters in an algorithm for warfarin dosing. These data provide a proof-in-principle of multiplexed SNP analysis using rapid single-base extension and capillary electrophoresis, and warrant additional validation using a larger cohort of patient samples.
Interindividual and Interethnic Variation in Genomewide Gene Expression: Insights into the Biological Variation of Gene Expression and Clinical Implications
Authors: Fan Harris P Y , Di Liao Chen , Fu Brenda Yan , Lam Linda C W , Tang Nelson L S 
Published: February 2009

AbstractBackground: Analysis of gene expression in peripheral blood samples is increasingly being applied in biomarker studies of disease diagnosis and prognosis. Although knowledge of interindividual and interethnic variation in gene expression is required to set ethnicity-specific reference intervals and to select reference genes and preferred markers from a list of candidate genes, few studies have attempted to characterize such biological variation on a genomewide scale.Methods: The genomewide expression profiles of 11 355 transcripts expressed among 210 multiethnic individuals of the HapMap project were obtained and analyzed; 4 replicates were included for each sample. The total biological CV in gene expression (CVb) was partitioned into interindividual (CVg), inter-ethnic group (CVe), and residual components by random-effects mixed models.Results: CVg was the major component of CVb, and the differences among transcripts were large (up to 38%). Distinct groups of genes were characterized by CV values and expression levels. Of the genes with lowest biological variation (CVb &lt; 1.5%), 35 genes were highly expressed, whereas 32 had intermediate or low expression. Although CVg was almost always greater than CVe, we identified 10 genes in which ethnic variation predominated (range, 8%–18%). On the other hand, 17 annotated genes were highly variable with CVg values ranging between 15% and 38%.Conclusions: Genomewide analysis of gene expression variation demonstrated biological differences among transcripts. Transcripts with the least biological variation are better candidates for reference genes, whereas those with low interindividual variation may be good disease markers. The presence of interethnic variation suggests that ethnicity-specific reference intervals may be necessary.
Overinterpretation of Clinical Applicability in Molecular Diagnostic Research
Authors: Lumbreras Blanca , Parker Lucy A , Porta Miquel , Pollán Marina , Ioannidis John P A , Hernández-Aguado Ildefonso 
Published: February 2009

AbstractBackground: We evaluated whether articles on molecular diagnostic tests interpret appropriately the clinical applicability of their results.Methods: We selected original-research articles published in 2006 that addressed the diagnostic value of a molecular test. We defined overinterpretation of clinical applicability by means of prespecified rules that evaluated study design, conclusions regarding applicability, presence of statements suggesting the need for further clinical evaluation of the test, and diagnostic accuracy. Two reviewers independently evaluated the articles; consensus was reached after discussion and arbitration by a third reviewer.Results: Of 108 articles included in the study, 82 (76%) used a design that used healthy controls or alternative-diagnosis controls, only 15 (11%) addressed a clinically relevant population similar to that in which the test might be applied in practice, 104 articles (96%) made definitely favorable or promising statements regarding clinical applicability, and 61 (56%) of the articles apparently overinterpreted the clinical applicability of their findings. Articles published in journals with higher impact factors were more likely to overinterpret their results than those with lower impact factors (adjusted odds ratio, 1.71 per impact factor quartile; 95% CI, 1.09–2.69; P = 0.020). Overinterpretation was more common when authors were based in laboratories than in clinical settings (adjusted odds ratio, 18.7; 95% CI, 1.41–249; P = 0.036).Conclusions: Although expectations are high for new diagnostic tests based on molecular techniques, the majority of published research has involved preclinical phases of research. Overinterpretation of the clinical applicability of findings for new molecular diagnostic tests is common.