bluuebunny/crossref_metadata_2025_split huggingface dataset:
NEO-CHONDROGENESIS USING AUTOLOGOUS MATRIX-INDUCED MEMBRANE (AMIC) IN THE TREATMENT OF FREIBERG'S DISEASE OF LESSER METATARSALS: UP TO SEVEN-YEAR FOLLOW-UP RESULTS
Authors: Koshy George , Rajeev Aysha , Devalia Kailash 
Published: February 2025

BackgroundFreibergs infraction is osteonecrosis of lesser metatarsal heads, most commonly affecting adolescent females. They usually present with pain and swelling of the forefoot. Surgical options include open debridement, cheilectomy, micro fracture osteotomy and excision arthroplasty. The aim of the study is to present the results of our surgical method based on the principle of neo-angiogenesis, neo-osteogenesis and neo-chondrogenesis with bone grafting and AMIC membrane application for Freiberg's disease of lesser metatarsals.MethodsA prospective analysis of twelve patients who had Freiberg's infraction of the lesser toe metatarsals treated with open debridement, microfracture, bone grafting and application of AMIC membrane was carried out. The patients were followed up to seven years and the outcome measures were scored using Smillie's classification, radiological findings and the Manchester-Oxford Foot Questionnaire (MOxFQ).ResultsThere were 9 (75%) female and 3(25%) male patients. The mean age was 42.7 years (range- 19 to 60). The mean follow-up time was 6.6 years. The most common site was second metatarsal, ten (83%) followed by third metatarsal, two (17%). According to Smillie's classification three lesions were labelled as Stage 3 and ten as Stage 4. There were no postoperative infections. None of the patients needed any further surgical intervention.The mean base line MOxFQ was 43.75 (SD- 43.75±12.40) which improved to 7.19(SD-7.18±4.63) the mean baseline EQ-5D improved from 7.85 (SD-7.85±5.08) to1.39(SD-1.39±0.75) at the final follow up. 80 % of the patients had complete remodelling of the head of metatarsal at the final follow up radiology.ConclusionsOpen debridement of the Freiberg\'s disease combined with microfracture of the defect, bone grafting and application of AMIC membrane gives good long term functional outcomes.
GRAVITATIONAL STRESS VIEWS OVERESTIMATE ANKLE INSTABILITY AND MAY COMMIT PATIENTS TO UNNECESSARY SURGERY: A PROSPECTIVE SERIES WITH TEN-YEAR FOLLOW-UP
Authors: Heinz Nicholas , Hanif Hamzah , Bugler Kate , Duckworth Andrew , White Timothy 
Published: February 2025

BackgroundDistinguishing stable from unstable ankle fractures is key to successful ankle fracture management. Gravitational stress views (GSV) may be a convenient and less painful alternative to manual stress testing. The aim of this study was to assess whether this test accurately predicts ankle instability.MethodsPatients presenting to a single trauma centre between 2011 and 2013 with an isolated fibula fracture and a an anatomically-aligned mortise on initial plain film radiographs were reviewed. After initial x-ray, patients underwent a gravity stress view. Measurements from plain film radiographs were recorded and analysed. Electronic case notes and National Imaging Archives were reviewed retrospectively at a minimum of 10 years post-injury. Patients were contacted to complete patient reported outcome measures (PROMS).ResultsOne-hundred and forty-two (142) patients met the inclusion criteria and were included in the study. Mean initial film medial clear space (MCS) measurement was 3.46mm (1.0 to 6.0) compared to GSV MCS that was 4.9mm (2.0 to 8.8) (p<0.001). No patient underwent surgery and all patients had successful conservative management with anatomical union seen at their 6 week radiograph. No patient returned with a complication related to their ankle fracture during the follow-up period. With a MCS acquired from GSV of >5mm, 65 patients would have undergone unnecessary surgical intervention. At MCS of >6mm, 26 patients would have undergone surgery unnecessarily and at a MCS of >7mm 10 patients would have had unnecessary surgery. To date, 50 patients have provided PROMs. Mean Olerud and Molander Score (OMAS) at 10 years was 86.63 (SD 23.27, 95% CI 79.47 – 93.79), Manchester Oxford Foot Questionnaire (MOXFQ) was 79.41 (SD 32.94, 95% CI 69.39 – 89.42) and Euroqol-5D-3L was 0.86 (SD0.22, 95% CI 0.79 – 0.93).ConclusionStress views may over-diagnose instability in patients with an isolated fibula fracture in an otherwise normal initial radiograph.
FIFTH METATARSAL FRACTURE PATTERN MAPPING AND ASSOCIATED OUTCOMES: AN OBSERVATIONAL COHORT STUDY
Authors: Gomaa Abdul-Rahman , Apata-Omisore Jejelola , Aslam Shahjahan , Marsh Luke , Paramasivan Arjun , Ward Nicholas , Galhoum Ahmed , Mason Lyndon 
Published: February 2025

IntroductionFifth metatarsal fractures have been regularly classified by zones, with the description of a Jones fracture commonly being misrepresented. The aim of this study was to map the fracture patterns across the entire metatarsal shaft, and correlate with their outcomes.MethodsA historic cohort study was completed of all fifth metatarsal fractures presenting to our unit between February 2016 – July 2021. Fracture patterns were individually mapped and designated as zone 1-shaft, including designation of fractures which bridge each zone (zone 1–2 etc). Fracture patterns were cumulatively combined using GNU Image Manipulation Program to show the combined fracture map patterns per outcome. The clinical notes were examined to assess patient outcome.Results1331 fractures were included in this study and presented graphically as fracture maps by outcome. The number of fractures which did not propagate across more than 1 zone was 78.59% (1046/1331). The fracture type which had the highest rate of discharge at VFC without reattendance was Zone 1 fractures (360/519, 69.36%), with the lowest being fractures where the fracture spanned zone 1-shaft (p<0.001).The total number of fractures that underwent surgery was 1.35% (18/1331). The fracture pattern which had the highest rate of surgical intervention was a fracture that spanned zone 2–3 (5/43, 11.63%) followed by a fracture that spanned zone 1–3 (1/11, 9.9%).The number of appointments given to patients ranged from discharged from VFC to 7 face to face appointments. The patients with the lowest discharge rate prior to 4 appointments was zone 2–3.ConclusionsIn our series, almost a quarter of fractures spanned across the previously described fracture zones. This would explain the low inter-observer rating in previous studies. The classic Jones fracture would span zones 2/3, which in our series had the highest rate requiring surgery and lowest rate of discharge before 4 appointments.
Olympic combat sports and mental health in children and adolescents with disability: A protocol paper for systematic review
Authors: Lee Youngjun , Capranica Laura , Pesce Caterina , Guidotti Flavia , Benzing Valentin , Hauck Janet , Ciaccioni Simone 
Published: February 2025

Introduction
Mental health is important for children and adolescents, particularly those with disabilities. While the mental health advantages of sports participation are well-documented, the specific type of sport may have heightened relevance for children and adolescents with disabilities. The objective of this systematic review protocol is to outline the rationale and methodology for investigating how participation in Olympic combat sports influences the mental health outcomes of this unique population, which is more susceptible to developing mental health issues than their neurotypical counterparts.

Methods and analysis
A comprehensive search will be conducted across academic databases, including the Cochrane Library, ERIC, PsycINFO, PubMed, Scopus, SPORTDiscus, and Web of Science. The focus will be on identifying randomized and non-randomized controlled trials (RCTs and non-RCTs, respectively), and observational studies with control groups that explore the impact of Olympic combat sports on the mental health of children and adolescents with disabilities. To assess the risk of bias, the Rob 2.0 tool will be employed for RCTs, and the ROBINS-I tool for CTs. For longitudinal and cross-sectional studies, the National Institute of Health’s Study Quality Assessment Tool for Observational Cohort and Cross-sectional Studies will be used. The review process will be conducted using Covidence, possibly utilizing JASP software for meta-analysis if the retrieved studies exhibit sufficient homogeneity. Data that cannot be included in the meta-analysis will be synthesized using the Synthesis without Meta-Analysis (SWiM) tool. Furthermore, the Consolidated Framework for Implementation Research (CFIR) will provide a framework consisting of five broad domains: intervention characteristics, outer setting, inner setting, characteristics of individuals, and the process of implementation.
Implementation and first report of the Brazilian Kidney Biopsy Registry
Authors: Noronha Irene L. , Ramalho Rodrigo José , Oliveira Claudia Maria Costa de , Bahiense-Oliveira Marilia , Barbosa Fabricio Augusto Marques , Barros Neto Jose de Resende , Mitsuoka Ronny , Vieira-Neto Osvaldo Merege , Neves Precil Diego Miranda de Menezes ,   on behalf of the Brazilian Kidney Biopsy Registry Working Group
Published: February 2025

Background
Kidney biopsy registries are valuable tools for guiding clinical practice and developing health policies. In 2021, the Brazilian Society of Nephrology (SBN) created the Brazilian Kidney Biopsy Registry (BKBR). This is the first BKBR report, presenting patient data from 2021.

Methods
BKBR is a web-based platform hosted on the BSN website, which contains patient demographics, clinical data, frequency, and distribution of histologic diagnosis of Brazilian adult native kidney biopsies.

Results
Of the 1012 cases registered in 2021, 954 cases were evaluated after excluding pediatric and kidney transplant cases. Twenty-one centers enrolled patients, with representation from all Brazilian regions. There was a slight predominance of females (52.6%), a mean age of 44.7 ± 16 years, and 13.6% of patients were >65 years old. The main indication for kidney biopsy was renal dysfunction (56%) and nephrotic syndrome (41.4%), respectively. At the time of the biopsy, 47.9% of the patients were hypertensive and 15.2% were diabetic. Although 66.2% of patients had eGFR ≤60ml/min/1.73m2 upon biopsy, the majority (60.2%) had mild interstitial fibrosis and tubular atrophy. The most frequent diagnosis in the BKBR was glomerular disease (74.8%). Lupus nephritis was the most frequent diagnosis of glomerular disease (22.6%), followed by IgA nephropathy (13%) and focal segmental glomerulosclerosis (12.2%).

Conclusion
This is the first report of a Nationwide registry of kidney biopsies in Brazil. This data provides pivotal information about the kidney disease profile in this country with continental dimensions.
Perception of four intellectual and developmental disabilities based on search engine and news portrayal
Authors: Droscha Lillian J. , Chung Sophia , Li-Khan Zoe , Scott Ashley , Rubenstein Eric 
Published: February 2025

Background
For people with intellectual and developmental disabilities, other’s perceptions of them based on their condition often begin before birth and go on to impact relationships, opportunities, and self perception across the life course. Search engine results and news media, which may portray these conditions stereotypically or in poor light, are often a key source in these perceptions. Our purpose was to understand how search engine results and available news media can shape perceptions on certain intellectual and developmental disabilities.

Methods
We developed an online Likert-scale survey to measure differences in perceptions based off first available search engine results, images, and news headlines of four intellectual and developmental disabilities: cerebral palsy, Down syndrome, Prader-Willi syndrome, and Angelman syndrome. These four conditions were selected to compare less prevalent (Prader-Willi and Angelman) and more prevalent conditions (Down syndrome and cerebral palsy). Perception questions addressed general impression and aspects of the disability experience expected to be impacted by perception from others. We recruited via multiple social media platforms, flyers posted in the Boston area, and word of mouth to local communities and friends.

Findings
229 individuals opened the survey, and 125 responses were used in analysis. Mean responses to Prader-Willi syndrome were significantly more negative than responses to cerebral palsy, Down syndrome, and Angelman syndrome across all variables. Responses to Angelman syndrome were also more negative than responses to Down syndrome. Significant differences between conditions found when treating the data as continuous were confirmed when treating the data as ordinal.

Conclusion
Lesser-known intellectual and developmental disabilities, such as Prader-Willi syndrome and Angelman syndrome, are subject to more negative portrayal in media, leading to more negative perception, which may impact social opportunity and quality of life. Combined with our finding that the perception of Prader-Willi syndrome follows the ideals of the medical model of disability more closely than the social model, a need for social model of disability training and education for physicians and other medical providers is clear.
Does patients’ age predict their clinical outcomes following non-infectious epiglottitis? A systematic review
Authors: Safia Alaa , Abd Elhadi Uday , Shehadeh Rabie , Farhat Raed , Asakly Majd , El Khatib Nidal , Khater Ashraf , Bishara Taiser , Massoud Saqr , Merchavy Shlomo 
Published: February 2025

Background
Non-infectious epiglottitis, an infrequent but significant condition, presents challenges in airway management and treatment due to its potential for rapid progression.

Objective
To analyze differences in clinicodemographic characteristics, management strategies, and clinical outcomes between pediatric and adult cases of non-infectious epiglottitis.

Methods
A systematic search of four databases identified 57 patient records, all diagnosed with non-infectious epiglottitis. Children (<18 years) were compared to adults (≥18 years). Differences in clinicodemographic characteristics, management strategies, and clinical outcomes were analyzed. Outcomes included intubation, complications, and intensive care unit (ICU) admission. Risk factors of these outcomes were identified through uni- and multi-variable logistic regression analyses.

Results
Twenty-three children and 34 adults were analyzed. The presentation with stridor (56.52% vs. 14.7%), drooling (56.52% vs. 26.47%), cyanosis (17.39% vs. 0%), and sternal retraction (13.04% vs. 0%) was more common among children. Prior vaccination was evident in only 5 pediatric cases. The etiology of epiglottitis was similar across groups. Children had significantly higher chances of receiving epinephrine (34.78% vs. 8.82%), undergoing intubation (82.60% vs. 20.58%), being admitted to the ICU (56.52% vs. 17.64%), and having complications (47.82% vs. 14.70%), compared to adults. In the multivariate regression model, pediatric age was a risk factor for intubation (p = 0.015) and ICU admission (p = 0.040), while foreign body ingestion (p = 0.039) and dyspnea (p = 0.014) were predictors of intubation and complications, respectively.

Conclusions
The study highlights the necessity for age-specific management strategies in non-infectious epiglottitis. Understanding the distinct clinical presentations and responses in different age groups can lead to improved patient care.
Barriers and facilitators of adherence to treatment interventions for COPD amongst individuals from minority ethnic communities: Meta-ethnography
Authors: Alamer Sarah , Robinson-Barellla Anna , Cooper Matthew , Nazar Hamde , Husband Andy 
Published: February 2025

Objective
Numerous studies have documented the low adherence rate to treatment interventions for Chronic Obstructive Pulmonary Disease (COPD) amongst minority ethnic communities. This systematic meta-ethnographic review was performed to identify barriers and facilitators of adherence to treatment interventions (e.g., smoking cessation and pulmonary rehabilitation) of COPD in minority ethnic communities.

Method
This systematic meta-ethnographic review followed the approach by Noblit and Hare. Systematic searches were performed across six databases MEDLINE (OVID), EMBASE (OVID), CINAHL (EBSCO), PsycINFO (OVID), Web of Science, and Scopus from their inception until November 2023. Quality appraisal of included studies was conducted using Critical Appraisal Skills Programme (CASP) tools.

Results
Out of 1,329 identified citations, seven qualitative studies were included in this meta-ethnography. Using reciprocal translation, four overarching themes were developed to represent the barriers and facilitators of adherence to treatment interventions of COPD amongst minority ethnic communities: 1) positive and negative experiences affecting a person’s motivation for their care, 2) patient attitude and beliefs, 3) being able to access and attend care, and 4) the influence of communication and culture on a person’s care.

Conclusion
This review highlighted the barriers and facilitators of adherence to treatment interventions for COPD amongst individuals from minority ethnic communities. The key barriers include language difficulties and the inability to comprehend and communicate effectively with healthcare professionals. This demonstrates the need for further research on the impact of linguistic and cultural characteristics on adherence to treatment interventions for COPD. Addressing ethnicity-specific barriers could inform the development of tailored protocols and strategies for optimising adherence among minority ethnic communities. (PROSPERO CRD42023476187).
The Follicular Distribution during the Estrus Phase and the Enhanced Estrus Behavior of Crossed Ongole Heifers Stimulated with a Non-superovulation Dose of PMSG
Authors: Putro Krido Brahmo , Amrozi Amrozi , Winarto Adi , Boediono Arief , Manalu Wasmen 
Published: February 2025

The experiment's objective was to study the follicle distribution during the estrus phase and the estrus performance of the Ongole-crossed heifer by injecting a non-superovulation (NSO) dose of PMSG. Nine PO heifers were randomly assigned to one of three treatment groups, each receiving a different dose of PMSG injection, i.e., 0, 0.5, and 1.0 IU/kg BW, respectively; this was done at the early second follicular phase. The evaluation was conducted during the estrus phase to assess follicle distribution and estrus performance and to collect the reproductive tract for biometrics evaluation. The results demonstrated that PMSG injection at doses of 0.5 and 1.0 IU resulted in an increase in mean follicle diameter size above 0.8 cm by 7.08 % (P0.05) and 15.04 % (P0.05), respectively. However, the total number of follicles above 0.8 cm at 1.0 IU/kg BW dose remains high (5.33±2.52, P0.05), indicating a continued propensity for multiple calving. The results demonstrated that the estrus performance score was enhanced with the administration of increasing doses of PMSG, which was accompanied by an increase in the biometrics of the ovaries (P0.05) and the diameter of the uterine body, uterine horn, and cervix (P0.05). It was concluded that the NSO dose of PMSG could facilitate follicle development and enhance estrus quality without increasing the risk of multiple calving.
Current understanding of diagnosis, treatment and predictors of papillary thyroid microcarcinoma progression
Authors: Dzodzaeva A. V. , Bondarenko E. V. , Terekhova M. A. , Vanushko A. V. , Vanushko V. E. , Troshina E. A. 
Published: February 2025

Papillary Microcarcinoma of the Thyroid Gland (PMTC) is the most common type of malignant thyroid neoplasm, characterized by its small size and generally favorable prognosis. The increased detection rate of PMTC is associated with advancements in high-precision diagnostic methods such as ultrasound and fine-needle aspiration biopsy. Diagnostic approaches include the use of the EU-TIRADS and Bethesda systems for risk assessment, as well as the analysis of molecular markers, such as BRAF gene mutations and promising studies on the role of microRNAs in predicting tumor progression.Optimal management of patients with PMTC requires an individualized therapeutic approach due to differences in disease progression. This article analyzes current diagnostic and treatment methods for PMTC, including the use of molecular-genetic markers, minimally invasive technologies, and active surveillance strategies, with an emphasis on a personalized approach to prognosis and therapy.
A variational approach to the Navier–Stokes equations with shear-dependent viscosity
Authors: Lienstromberg Christina , Schiffer Stefan , Schubert Richard 
Published: February 2025

Abstract
We present a variational approach for the construction of Leray–Hopf solutions to the non-Newtonian Navier–Stokes system. Inspired by the work [M. Ortiz, B. Schmidt and U. Stefanelli,
A variational approach to Navier–Stokes,
Nonlinearity 31 2018, 12, 5664–5682] on the corresponding Newtonian problem, we minimise certain stabilised Weighted Inertia-Dissipation-Energy (WIDE) functionals and pass to the limit of a vanishing parameter in order to recover a Leray–Hopf solution of the non-Newtonian Navier–Stokes equations.
The investigation of the non-Newtonian Navier–Stokes system via this variational approach is particularly well suited to gain insights into weak, respectively strong convergence properties of approximating sequences for different flow-behaviour exponents. With this analysis we extend the results of [M. Bathory and U. Stefanelli,
Variational resolution of outflow boundary conditions for incompressible Navier–Stokes,
Nonlinearity 35 2022, 11, 5553–5592] to power-law exponents

2
⁢
d

d
+
2

<
p
<

3
⁢
d

+
2

d
+
2

{\tfrac{2d}{d+2}<p<\tfrac{3d+2}{d+2}}

, where weak solutions do not satisfy the energy equality and the involved convergence is genuinely weak. Key of the argument is to pass to the limit in the nonlinear viscosity term in the time-dependent setting. For this we provide an elliptic-parabolic solenoidal Lipschitz truncation that might be of independent interest.
A trace formula for Hecke operators on Fuchsian groups
Authors: Popa Alexandru A. 
Published: February 2025

Abstract
In this paper we give a trace formula for Hecke operators acting on the
cohomology of a Fuchsian group of finite covolume Γ with coefficients in a module V.
The proof is based on constructing an operator whose trace on V equals the
Lefschetz number of the Hecke correspondence on cohomology, generalizing the operator introduced
together with Don Zagier for the modular group.
Locally compact groups with all dense subgroups separable
Authors: Peng Dekui 
Published: February 2025

Abstract
By a recent result of Juhász and van Mill, a locally compact topological group whose dense subspaces are all separable is metrizable. In this note we investigate the following question: Is every locally compact group having all dense subgroups separable also metrizable?
We give an example to show the answer is negative for locally compact abelian groups, thereby showing that one cannot directly generalize the assertion by replacing “subspaces” with “subgroups”. On the other hand, we prove that the answer is positive for compact groups which are either connected or algebraically abelian; and for locally compact groups containing only separable subgroups. As an application, we obtain a necessary condition for metrizability of pronilpotent groups.