bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stronger connectivity among reward, cognitive, and attention networks in people with severe Opioid Use Disorder compared with healthy controls.
Authors: Kurtin Danielle , Herlinger Katherine , Hayes Alexandra , Hand Lexi , Fonville Leon , Hill Raymond , Nutt David , Lingford-Hughes Anne , Paterson Louise 
Published: March 2024

Abstract
One approach to addressing the immense unmet need for treatments of severe Opioid Use Disorder (sOUD) is to understand more about associated changes in the brain’s reward circuitry. It has been shown that during reward anticipation in the Monetary Incentive Delay (MID) task, people with severe substance use disorder (SUD) show blunted responses in reward neural circuitry compared with healthy controls (HC). Conversely, drug-related cues result in heightened responses in the same neural reward circuitry in those with SUD compared with HC. However, it is unclear how such dysfunctional reward processing is related to neural correlates of other processes commonly dysregulated in addiction, such as attention and cognition. The aim of this work was to evaluate whether people with sOUD show different spatiotemporal relationships between reward networks to cognitive and attentional networks. We collected fMRI data while people with sOUD receiving methadone (MD; n = 22) and HC (n = 22) completed the MID and Cue Reactivity tasks. We evaluated differences in functional connectivity (FC) and measures of brain state dynamics. We explored the relationship between FC to µ-Opioid receptor (MOR) and Dopamine D2 Receptor (DRD2) availability due to their involvement in reward processing. During both the MID and Cue Reactivity tasks, MD participants showed significantly higher mutual information FC between regions in the reward network to those in attention and cognitive networks. We found significant, positive relationships between the higher FC in MD vs HC participants and the sum of MOR and D2 receptor availability during the Cue Reactivity task. In summary, the higher integration among reward, attentional, and cognitive networks in MD participants during both non-drug and drug-related tasks suggests that the relationship between these networks is dysregulated in addiction. These mechanistic insights provide alternative targets for treatment to improve sOUD outcomes.
Mapping the global variation in the efficiency of ocean alkalinity enhancement for carbon dioxide removal
Authors: Zhou Mengyang , Tyka Michael , Ho David , Yankovsky Elizabeth , Bachman Scott , Nicholas Thomas , Karspeck Alicia , Long Matthew 
Published: March 2024

Abstract

To limit global warming to below 2°C by 2100, carbon dioxide removal (CDR) from the atmosphere will be necessary. Ocean alkalinity enhancement (OAE) is a promising approach to achieving CDR at scale. However, OAE deployments are subject to incomplete air-sea CO2 equilibration — reducing the efficiency of carbon removal. Here, we generated the first global maps of OAE efficiency, including an assessment of the seasonal variation in efficiency. We show that the equilibration kinetics exhibit two characteristic timescales — rapid surface equilibration followed by a slower second phase, representing the re-emergence of excess alkalinity that was initially subducted. These kinetics vary considerably with latitude and the season of alkalinity release, both critical considerations for the placement of prospective OAE deployments. We also calculated histograms quantifying the spatial and temporal scales of the induced CO2 uptake and thus identifying the requirements for modeling OAE in regional ocean models.
Szerencsejátékosok attitűdjeinek időbeli összehasonlító vizsgálata
Authors: Tessényi Judit 
Published: March 2024

Az attitűd értelmezhető egyrészt, mint az egyén vélekedésének függvénye – esetünkben pl. a szerencsejátékok hasznosságáról/károsságáról -, másrészt a társas viselkedés belső irányítója (hajtóerő, motiváció, késztetés). A vizsgálatok önálló szegmensét képezik az attitűdkutatások, ahol is azt vizsgáljuk, hogy „az egyének viselkedése milyen kognitív és érzelmi tényezők hatására alakul. Jelenleg még az is vitatott, hogy az attitűdkutatások és attitűdskálák alkalmasak-e egyáltalán az attitűd mérésére, mivel a kapott eredmények nem egyértelműen tudtak kapcsolatot kimutatni a viselkedéssel” (Tessényi 2013: 73). Az attitűd – Allport definíciója alapján - tapasztalat révén szerveződött mentális és idegi készenléti állapot, mely irányító vagy dinamikus – késztető, mozgósító hatást gyakorol az egyén reagálására mindazon helyzetek irányában, amelyekre az attitűd vonatkozik (Allport 1935). Alább ismertetett vizsgálatunk 2016-ban, 2020-ban és 2023-ban felvett minták időbeli összehasonlító statisztikai elemzését tartalmazza és annak a hipotézisnek a vizsgálata, mely szerint a játékfüggők attitűdértékeinek átlagértéke és szórása nagyobb, mint a nem problémás játékosoké.
„Csodarabbik útja 2” : Szellemi rekreáció a helyi lakosok szemszögéből Bodrogkeresztúron
Authors: Rozgonyiné Drotár Nikolett , Petykó Csilla , Szalók Csilla , Nagy Adrienn 
Published: March 2024

A „Csodarabbik útja” szellemi rekreációs lehetőségeiről született egy cikk, mely a 2023 tavaszi lapszámban olvasható. Ennek a folytatásaként most egy konkrét helyszínre szűkítettük a kutatást, Bodrogkeresztúrra, az útvonal legjobban látogatott településére. A hitélet egyértelműen szellemi rekreáció és utazási motiváció. A túlturizmus jellemzője, hogy egy adott turisztikai desztinációban egy időben a turizmus hatása meghaladja a fizikai, ökológiai, pszichológiai, társadalmi és gazdasági küszöbértéket (Vanyúr B. 2021). Azért választottuk Bodrogkeresztúrt a kutatási területünknek, mert 2023-ban négy nap alatt a 877 fős községbe (KSH 2022) ötvenezer zsidó zarándok érkezett. A kutatási kérdés arra irányult, hogy megvalósul-e a túlturizmus a zsidó zarándokünnepen a községben? Gyakorol-e negatív hatást a magas turistaszám a helyi lakosok életminőségére? Eredményeink között a legfrissebb adatok és információk mellett a felmerülő problémák és az ezek megoldására tett intézkedések is megjelennek. Következtetéseink szerint ez a zarándok áradat negatívan hat a helyi lakosok életminőségére.
Valorization of fat balls and primary scum from wastewater treatment: a promising renewable lipid feedstock for biodiesel production
Authors: Rizkianto Febrian , Oshita Kazuyuki , Takaoka Masaki 
Published: March 2024

ABSTRACT

We investigated the potential of waste materials from wastewater treatment plants (WWTPs) to serve as an alternative lipid feedstock for biodiesel production. The average lipid recoveries from fat balls (46.4%) and primary scum (49.5–54.5%) were higher than the lipid recovery of primary sludge (15.8–16.4%). The yield of biodiesel produced from the extracted lipids ranged from 5.7 to 20.1%. There were considerable site- and season-dependent variations in the characteristics of the lipid waste materials. Radiocarbon analysis indicated the presence of fossil-derived carbon (26.0–42.0%) in the biodiesel obtained from wastewater lipids. Finally, we estimated the potential for biodiesel production from WWTP-derived lipids; about 333.0 metric tons of biodiesel per year could be produced from fat balls and primary scum in Japan. The results indicate that lipid-rich materials from WWTPs represent a valuable alternative feedstock for biodiesel production.
Aumento en el acervo geotécnico de los constructores de hipogeos entre los Reinos Antiguo y Medio (Necrópolis Qubbet el-Hawa, Asuán)
Authors: Martínez Hermoso Juan Antonio , García Mellado Israel , Sánchez Gómez Mario 
Published: March 2024

La colina de Qubbet el-Hawa fue el lugar elegido para el cementerio de los altos funcionarios de la provincia más meridional del Antiguo Egipto, desde finales del Reino Antiguo hasta finales del Reino Medio. Hasta la fecha se han descubierto, a media ladera, un centenar de tumbas excavadas en la roca distribuidas en varias terrazas superpuestas. Del estudio geológico/geotécnico se desprende que no había mejor emplazamiento, en un tramo donde predominan las areniscas, delimitado por dos estratos especialmente resistentes que sirven como suelo y techo de los hipogeos, lo que en principio garantizaba su estabilidad. En este artículo analizamos dos tumbas representativas de los dos períodos más importantes del cementerio: QH34h (Dinastía VI) y QH33 (Dinastía XII), construidas con una diferencia temporal de unos 400 años. A partir del estudio de fracturación y del análisis de la estabilidad geotécnica en estas tumbas comprobamos que la más moderna (QH33), respecto de la más antigua (QH34h), presenta innovaciones constructivas y de diseño que solucionaron los problemas de estabilidad que presentaban algunas de las tumbas más antiguas. Este estudio demuestra que, en primer lugar, la elección del emplazamiento de las tumbas se realizó en función de la naturaleza resistente de los estratos, en segundo lugar, que los métodos constructivos utilizados por los antiguos egipcios estaban condicionados por la geología de la colina y, en tercer lugar, que, resultado de la experiencia adquirida durante años, el diseño de las tumbas evolucionó para solucionar los problemas de estabilidad del macizo rocoso.
Use of Chitosan as a Precursor for Multiple Applications in Medicinal
Chemistry: Recent Significant Contributions
Authors: Quiroga Diego , Coy-Barrera Carlos 
Published: March 2024

Abstract::
Chitosan (CS) is a polymer made up of mainly deacetylated β-1,4 D-glucosamine units,
which is part of a large group of D-glucosamine oligomers known as chitooligosaccharides, which
can be obtained from chitin, most abundant natural polymer after cellulose and central component of
the shrimp exoskeleton. It is known that it can be used for the development of materials, among
which its use stands out in wastewater treatment (removal of metal ions, dyes, and as a membrane in
purification processes), food industry (anti-cholesterol and fat, packaging material, preservative, and
food additive), agriculture (seed and fertilizer coating, controlled release agrochemicals), pulp and
paper industry (surface treatment, adhesive paper), cosmetics (body creams, lotions, etc.), in the engineering
of tissues, wound healing, as excipients for drug administration, gels, membranes, nanofibers,
beads, microparticles, nanoparticles, scaffolds, sponges, and diverse biological ones, specifically
antibacterial and antifungal activities. This article reviews the main contributions published in
the last ten years regarding the use and application of CS in medical chemistry. The applications
exposed here involve regenerative medicine in the design of bioprocesses and tissue engineering,
Pharmaceutical sciences to obtain biomaterials, polymers, biomedicine, and the use of nanomaterials
and nanotechnology, toxicology, and Clinical Pharmaceuticals, emphasizing the perspectives and
the direction that can take research in this area.
Computational Molecular Docking and In-Silico, ADMET Prediction Studies of
Quinoline Derivatives as EPHB4 Inhibitor
Authors: Mhaske Ganesh S. , Thorat Sanket R. , Pawar Varun S. , Pawar Ravindra S. , Jambhulkar Sarvesh R. , Ghumre Omkar A. 
Published: March 2024

Background::
The creation and development of novel chemical entities is made possible by numerous computer-aided drug design techniques. The ability to
visualize the ligand-target interaction and forecast the important holding pocket locations and affinities of ligands to their intended macromolecules
is made possible by pharmacophore-based drug design and understanding in-silico methodologies.

Objective::
The aim of the current investigation was to find novel 2-chloroquinoline-3-carboxamide derivatives that target the Ephrin B4 (EPHB4) receptor to
treat cancer.

Materials and Methods::
Chem Axon Marvin Sketch 5.11.5 was used to create derivatives of 2-chloroquinoline-3-carboxamide. The physicochemical characteristics of
compounds as well as their toxicity were predicted using SwissADME& the admet SAR online software’s. Molecular docking technology was
used to examine the ligand-receptor interactions of 2-chloroquinoline-3-carboxamide derivatives with the target receptor (PDB- 6FNM) using a
variety of software’s, including Autodock1.1.2,Procheck, ProtParam tool, Biovia Discovery Studio Visualizer v20.1.0.19295, MGL Tools 1.5.6,
PyMOL, and were all included.

Results::
All developed compounds were determined to be orally bioavailable, less toxic, and have acceptable pharmacokinetic properties according to in
silico studies. In comparison to the traditional medication Erdafitnib, all new compounds displayed higher docking scores.

Conclusion::
The increase in binding energy and the number of H-bonds created by novel derivatives with interactions at distances below 3.40A provide a
helpful starting point for formulating and synthesizing compounds that are most suitable for additional research. The application of the 2-
chloroquinoline-3-carboxamide moiety as a potential new cancer treatment candidate is supported by its pharmacokinetics &toxicological profile,
which may aid medicinal chemists in conducting more in-depth in vitro, in vivo chemical and pharmacological studies.
Potential Beneficial Effects of Mineral Sunscreens on Acne-Prone Skin
Authors: Gomes Marina , Vieira Lima Fabiana , Rosado Catarina , Pezzini Bianca Ramos 
Published: March 2024

Background:
Sunscreens are critical products used against harmful ultraviolet (UV)
radiation. However, beyond the effect of sun protection, the inorganic UV filters zinc oxide and
titanium dioxide have shown antimicrobial activity.

Objective:
This study aimed to evaluate the potential additional beneficial effects of mineral sunscreens containing zinc oxide and titanium dioxide as antimicrobial agents on acne-prone skin.

Methods:
Transepidermal water loss, skin hydration, and skin pH of twelve volunteers were
measured before and 2 h after the application of three mineral sunscreens. The antimicrobial activity of the mineral sunscreens was determined against Cutibacterium acnes, Staphylococcus
aureus, and Staphylococcus epidermidis in a time-kill test.

Results and Discussion:
The studied mineral sunscreens did not affect either the stratum corneum
hydration or its integrity, but they increased the skin pH from 4 to 6, which could impact the skin
microbiota balance. At the same time, the tested mineral sunscreens inhibited Cutibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus.

Conclusion:
This study suggests that the two UV filters can have positive effects on acne-prone
skin and, thus, extend the benefits of photoprotective formulations. Nevertheless, further research
is currently being conducted.
STRATEGI LAYANAN BIMBINGAN KARIER: PERSPEKTIF KARIER DITINJAU DARI PERKEMBANGAN SISWA PADA JENJANG SEKOLAH DASAR
Authors: Suherman Maya Masyita , Siddik Riesa Rismawati 
Published: March 2024

Career is a lifelong process, so it needs to be formed as early as possible to achieve a career that suits the individual. Career education can be started when the child is in elementary school. At this level, children begin to be introduced to jobs in the surrounding environment. In addition, teachers, parents and the community participate in providing learning about themselves to children related to gender, morals, social skills, Self-Esteem, and Self-Efficacy. The formation of one's career must start early, so that since elementary school a child must be given an understanding of career. The understanding given can be through games by introducing jobs that exist in the environment around the home and school. Career development for children also needs to be adjusted to their developmental tasks. as parents and teachers must also know the talents and interests of children from an early age to be able to better direct children. The directives carried out here are not coercion in accordance with the wishes of the parents/teachers, but according to the potential of the child.Keywords:Â Â Â service strategy, career guidance, elementary school
Longitudinal Change in Serum Neurofilament Light Chain in Type 2 Diabetes and Early Diabetic Polyneuropathy: ADDITION-Denmark
Authors: Määttä Laura L. , Andersen Signe T. , Parkner Tina , Hviid Claus V.B. , Bjerg Lasse , Kural Mustafa A. , Charles Morten , Søndergaard Esben , Kuhle Jens , Tankisi Hatice , Witte Daniel R. , Jensen Troels S. 
Published: March 2024

OBJECTIVE
To investigate the longitudinal development of neurofilament light chain (NfL) levels in type 2 diabetes with and without diabetic polyneuropathy (+/−DPN) and to explore the predictive potential of NfL as a biomarker for DPN.

RESEARCH DESIGN AND METHODS
We performed retrospective longitudinal case-control analysis of data from 178 participants of the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care-Denmark (ADDITION-Denmark) cohort of people with screen-detected type 2 diabetes. Biobank samples acquired at the ADDITION-Denmark 5- and 10-year follow-ups were analyzed for serum NfL (s-NfL) using single-molecule array, and the results were compared with established reference material to obtain NfL z-scores. DPN was diagnosed according to Toronto criteria for confirmed DPN at the 10-year follow-up.

RESULTS
s-NfL increased over time in +DPN (N = 39) and −DPN participants (N = 139) at levels above normal age-induced s-NfL increase. Longitudinal s-NfL change was greater in +DPN than in −DPN participants (17.4% [95% CI 4.3; 32.2] or 0.31 SD [95% CI 0.03; 0.60] higher s-NfL or NfL z-score increase in +DPN compared with −DPN). s-NfL at the 5-year follow-up was positively associated with nerve conduction studies at the 10-year follow-up (P = 0.02 to &lt;0.001), but not with DPN risk. Areas under the curve (AUCs) for s-NfL were not inferior to AUCs for the Michigan Neuropathy Screening Instrument questionnaire score or vibration detection thresholds. Higher yearly s-NfL increase was associated with higher DPN risk (odds ratio 1.36 [95% CI 1.08; 1.71] per 1 ng/L/year).

CONCLUSIONS
Our findings suggest that preceding s-NfL trajectories differ slightly between those with and without DPN and imply a possible biomarker value of s-NfL trajectories in DPN.
PENGARUH MODEL PEMBELAJARAN INKUIRI TERBIMBING BERBANTUAN PHET TERHADAP KEMAMPUAN BERPIKIR KRITIS PESERTA DIDIK
Authors: Ismawati  , P. Yasa  , D.O. Rachmawati  
Published: March 2024

Tujuan penelitian ini untuk mendeskripsikan perbedaan kemampuan berpikir kritis antara peserta didik yang belajar menggunakan model inkuiri terbimbing berbantuan PhET dengan model DI. Jenis penelitian ini adalah eksperimen semu dengan desain penelitian one way pretest-posttest non-equivalent control group design. Populasi penelitian ini adalah peserta didik kelas XI di SMA Negeri 1 Seririt sebanyak 151. Sampel penelitian menggunakan teknik simple randomize dan 2 kelas sampel penelitian dengan total sampel 76. Data kemampuan berpikir kritis diukur menggunakan instrumen berbentuk tes esai dengan reliabilitas sebesar 0,701 dan konsistensi internal tes bergerak pada 0,31-0,71. Data dianalisis dengan analisis deskriptif, analisis kovarian dan uji lanjut LSD dengan taraf signifikansi 5%. Hasil penelitian ini menunjukkan bahwa: (1) Kelompok dengan model inkuiri terbimbing-PhET memperoleh nilai rata-rata posttest sebesar 76,00 (SD = 7,10), sedangkan kelompok dengan model DI sebesar 49,01 (SD = 13,4). Hasil uji ANAKOVA menunjukkan bahwa terdapat perbedaan kemampuan berpikir kritis antara peserta didik yang belajar dengan model inkuri terbimbing-PhET dengan peserta didik yang belajar menggunakan model DI dengan nilai signifikansi 0,001. (2) Hasil uji LSD diperoleh bahwa * = 26,768 lebih besar dari nilai LSD hitung yang besarnya 7,91, sehingga model pembelajaran inkuiri terbimbing berbantuan PhET berpengaruh relatif lebih baik terhadap kemampuan berpikir kritis peserta didik dibandingkan dengan model pembelajaran DI. Simpulan hasil penelitian ini adalah terdapat perbedaan signifikan kemampuan berpikir kritis antara peserta didik yang belajar dengan model inkuri terbimbing-PhET dengan peserta didik yang belajar menggunakan model DI dengan taraf signifikansi 0,05.
Development of Student Worksheet Based on Guided Inquiry Using Articulate Storyline in Fungi Subject Matter for Tenth Grade at SMAN 2 Plus Panyabungan
Authors: Nst Fitri Afifah , Gultom Endang Sulistyarini 
Published: March 2024

This study aims to determine the feasibility of worksheets based on guided inquiry using Articulate storyline on fungi material. This study uses the ADDIE development model which consists of five steps, namely analysis, design, development, implementation, and evaluation. The results showed that teachers and students needed worksheet so that the worksheet was designed based on guided inquiry. The validation of material experts, learning experts, and design experts are in the very good category with an average score of 96.87%, 96.87%, and 88.46%. The biology teacher's assessment obtained an average of 98.4% which was included in the very good category, and the student response to the worksheet obtained an average of 96.07% which was included in the good category. The product developed is effective in achieving learning indicators on fungi subject matter in terms of the N-gain test with a medium category of 0.65%. So, it can be concluded that worksheet is suitable for use in the learning process.
STUDENTS' HIGHER ORDER THINKING SKILLS AND SELF REGULATED LEARNING ON GENERAL BIOLOGY COURSE OF FIRST SCIENCE STUDENTS' OF FMIPA UNIVERSITAS NEGERI MEDAN
Authors: Nurjannah Lisa , Hasruddin Hasruddin 
Published: March 2024

ABSTRACTThe aims of the study are to determine the application of higher order thinking skills and student self-regulated learning in the General Biology Course, Faculty of Mathematics and Natural Sciences, Universitas Negeri Medan. This research was conducted in the departments of Mathematics, Physics, Biology, Chemistry, Science and Computer Science. Sampling was done by random sampling, by taking 6 classes from different majors. The type of this research is descriptive-quantitative research. The number of higher order thinking skills tests was 15 items and self-regulated learning tests were 40 items. The test is validated first before being used as a research instrument, followed by a validity test of the instrument, a reliability test, a test of the level of difficulty and distinguishing power. The results showed that the application of students' higher-order thinking skills in the General Biology course at the Faculty of Mathematics and Natural Sciences was still in the low category. This can be seen from the results of the Mathematics Education class B, as much as 3% is in the perfect category, 28% is in the very good category, 7% is in the good category, and 60% is in the low category. In Physics Education class A, 38% are in the Perfect category, 38% are in the very good category, and 23% are in the low category. In the Biology A education class, 30% are in the perfect category, 5% are in the good category, and 65% are in the low category. In the Non-educational Chemistry class A, 28% were in the Perfect category, 17% were in the very good category, and 50% were in the low category. In IPA B class, 14% are in the perfect category, 28% are in the very good category, and 57% are in the low category. In computer science class C, 17% are in the perfect category, 33% are in the good category, and 50% are in the low category. Meanwhile, Self-Regulated Learning for Students of the Faculty of Mathematics and Natural Sciences in the General Biology course is included in good categories, this is because the application of the KKNI curriculum accustoms students to be able to study independently through the assignment of six compulsory assignments for students. Keyword: higher order thinking skills, self regulated learning, general biology.