bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stereoselective Total Synthesis of Pyranicin and 4‐Epi‐Pyranicin from Carbohydrate Precursors
Authors: Ambati Praveen , Gupta Akanksha , Bandi Anjaneyulu , Perali Ramu Sridhar 
Published: March 2024

AbstractHerein, we describe a simple and efficient pathway for the total synthesis of pyranicin and 4‐epi‐pyranicin by utilizing carbohydrates as chiral raw materials for the first time. The general synthetic strategy involves the formation of two main fragments: Fragment 1 is the central tetrahydropyran core, which was constructed in a total of 10 steps from 2,3,4,6‐tetra‐O‐acetyl D‐glucal via Ferrier‐type rearrangement and oxidative cyclization as the key steps. Fragment 2 is the butenolide fragment, which was obtained in a gram scale with a total of 14 steps from diacetyl‐L‐rhamnal involving a ring contraction strategy.
Pesticide Contamination Levels in the Stomach Contents of Wild Raccoons (Procyon lotor) and Masked Palm Civets (Paguma larvata) in Japan
Authors: Shinya So , Sashika Mariko , Minamikawa Miku , Itoh Tetsuji , Tanikawa Tsutomu , Tanaka Kazuyuki D. , Nakayama Shouta M. M. , Ishizuka Mayumi , Ikenaka Yoshinori 
Published: March 2024

Abstract
Pesticides, which are vital for agriculture, pose a significant threat to wildlife in transformed Japanese landscapes. Despite global reports of pesticide poisoning in animals, limited studies have examined current wildlife exposure in croplands or metropolitan areas in the region. Using liquid chromatography–tandem mass spectrometry (LC–MS/MS) and gas chromatography–tandem mass spectrometry (GC–MS/MS), our study aimed to assess the contamination status of 368 commonly used pesticides. The stomach contents of raccoons living in croplands contained 13 pesticides, including six herbicides and 11 fungicides. Neonicotinoid insecticides, some fungicides, and previously banned insecticides (benzene hexachloride and dichlofenthion) were most frequently detected and found at the highest concentrations, suggesting direct soil–plant transfer and direct consumption by crop-eating species. In masked palm civets living in metropolitan areas, four insecticides and six fungicides were detected, indicating urban wildlife exposure from raided dustbins, urban gardens, and lumber from houses. Although the maximum measured concentrations of all pesticides were lower than the acceptable daily intake for humans, it remains unclear whether these concentrations may have toxic or adverse health effects on the species evaluated in these transformed landscapes. Our study is the first to examine recent pesticide exposures in wild mammals in Japan. Application of the method we developed will lay the foundation for the examination of pesticides in other wildlife species to assist conservation management efforts in the region. Environ Toxicol Chem 2024;43:943–951. © 2024 SETAC
Towards an Approach to Co‐Execute System Models at the Enterprise Level
Authors: Bankauskaite Jovita , Strolia Zilvinas , Morkevicius Aurelijus 
Published: March 2024

ABSTRACTIndustry 4.0, the Internet of Things, and large‐scale system‐to‐system interactions are driving digital transformation in the industry. Model‐based systems engineering (MBSE) is one of the core paradigms behind this transformation. MBSE practices are widely applied to enterprise (including system of systems and mission) architectures, which become a crucial part of successful digital transformation. The core challenge today is not only how digital continuity can be maintained by connecting different layers of models (such as system models to system‐of‐systems models), but also how to perform detailed analysis and simulation at the enterprise level model. This paper studies Systems Modeling Language (SysML®) as the standard language to model systems, Unified Architecture Framework (UAF) as the framework, Unified Architecture Framework Modeling Language (UAFML) as the language to model enterprise architectures and proposes an approach for end‐to‐end co‐execution of the integrated enterprise model.
Role of mesenchymal stem cells‐derived exosomes on inflammation, apoptosis, fibrosis and telocyte modulation in doxorubicin‐induced cardiotoxicity: A closer look at the structural level
Authors: Imam Reda A. El Nasser , Aboulhoda Basma Emad , Amer Maha M. , Hassan Fatma E. , Alghamdi Mansour A. , Abdel‐Hamed Mohamed R. 
Published: March 2024

AbstractCardiotoxicity induced by doxorubicin (Dox) is a major complication in cancer patients. Exosomes (Ex) derived from mesenchymal cells could be a promising therapeutic for various heart diseases. This study investigated the role of Ex in Dox‐induced cardiotoxicity and its mechanistic insights, using Sacubitril/valsartan (S/V) as a reference drug widely recommended in heart failure management. The study involved 24 Wistar rats, divided into a control, Dox, Dox + S/V, and Dox + Ex groups. The rats were assessed for cardiac enzymes, inflammatory and oxidative stress markers. Immunohistochemical expression of caspase‐1, nuclear factor erythroid 2‐related factor 2 (NrF2), E‐Cadherin, CD117/c‐kit, and Platelet‐derived growth factor‐α (PDGFα) was evaluated. P53 and Annexin V were assessed by PCR. Histological examination was performed using hematoxylin and eosin and Sirius red stains. Ex ameliorated the adverse cardiac pathological changes and significantly decreased the cardiac enzymes and inflammatory and oxidative stress markers. Ex also exerted antifibrotic and antiapoptotic effect in heart tissue. Ex treatment also improved NrF2 immunohistochemistry, up‐regulated E‐Cadherin immune expression, and restored the telocyte markers CD117/c‐kit and PDGFα. Ex can mitigate Dox‐induced cardiotoxicity by acting as an anti‐inflammatory, antioxidant, antiapoptotic, and antifibrotic agents, restoring telocytes and modulating epithelial mesenchymal transition.Research Highlights
Exosomes exhibit positive expression for CD90 and CD105 whereas showing −ve expression for CD 34 by flow cytometry.
Exosomes restore the immunohistochemical expression of the telocytes markers CD117/c‐kit and PDGFα.
Exosomes alleviate myocardial apoptosis, oxidative stress and fibrosis.
Adolescent Reference Values for MR‐Derived Biventricular Strain Obtained Using Feature‐Tracking and Myocardial Tagging
Authors: Real Carlos , Párraga Rocío , González‐Calvo Ernesto , Gutiérrez‐Ortiz Eva , Díaz‐Muñoz Raquel , Sánchez‐González Javier , Beneito‐Durá María , Martínez‐Gómez Jesús , Pizarro Gonzalo , García‐Lunar Inés , Fernández‐Jiménez Rodrigo 
Published: March 2024

BackgroundMyocardial strain is a promising marker for the detection of early left or right ventricular (LV or RV) dysfunction in pediatric populations. The reference standard for MR strain measurement is myocardial tagging (MT); however, MT has limited clinical utility because the additional acquisitions needed are time‐consuming. In contrast, MR‐feature tracking (FT) allows strain quantification from routinely acquired cine sequences. Studies providing reference values obtained with both FT and MT for adolescents are lacking.PurposeTo use MR‐FT and MT to define sex‐specific LV and RV strain reference values for adolescents.Study TypeCross‐sectional, prospective.PopulationOne hundred twenty‐three adolescents aged 15–18 years (52% girls) without known cardiovascular disease.Field Strength/SequenceBalanced steady‐state free‐precession sequence for FT analysis and a spatial modulation of magnetization hybrid TFE‐EPI sequence for MT acquisitions at 3.0‐T.AssessmentSegment Medviso software was used to obtain longitudinal (LS) and circumferential (CS) strain for both ventricles, and radial strain (RS) for LV.Statistical TestsThe Student t‐test was used for between‐sex comparisons of continuous variables. Sex‐specific percentiles were calculated using the weighted average method. Intraobserver and interobserver agreement was assessed in 30 randomly selected studies using intraclass correlation coefficients (ICC). A P‐value <0.05 was considered statistically significant.ResultsFT‐derived LVLS and LVCS were significantly higher in girls than in boys (−19.8% vs. −17.8% and −22.2% vs. −21.0%, respectively), as they were with MT (LVLS: −18.1% vs. −16.8%; LVCS: −20.8% vs. −19.7%). FT‐LVRS was higher in girls than in boys (44.8% vs. 35.1%), while MT‐LVRS was the opposite (18.6% vs. 22.7%). FT‐RVLS was higher in girls (−23.4% vs. −21.3%), but there were no between‐sex differences in MT‐derived RVLS or RVCS. ICC values for intraobserver agreement were ≥0.89, whereas for interobserver agreement were <0.80 for MT‐LVRS and ≥0.80 for all remaining parameters.Data ConclusionThis study provides sex‐specific reference biventricular strain values obtained with MR‐MT and MR‐FT for adolescents aged 15–18 years. MR‐FT may be a valid method for obtaining strain values in pediatric populations.Evidence Level1Technical EfficacyStage 3
Creativity in the Ancient Greek Philosophy: The Politics of Demiourgein
Authors: Zafeirenia Brokalaki 
Published: March 2024

ABSTRACTWhere does creativity come from and what is its purpose? The paper revisits these ever‐turning questions to correct the prevalent but, arguably, inaccurate historical interpretation of creativity as a concept that emerged in modernity. First, I substantiate that a close study of the ancient Greek texts suggests that although creativity seems to occupy a peripheral position in the ancient philosophical thinking, it is a central, yet, hidden, subject of speculation. Second, I overturn the worn‐out view that the ancient Greek philosophy conceives creativity as a God‐given talent breathed into a fortunate few. Last, I demonstrate that a more encompassing understanding of creativity is implied by several Greek philosophers. To achieve this, (a) I discuss the contemporary interpretations of the ancient notion; (b) I examine the historical origin and etymology of the Greek term demiourgein (“to create”) to discuss its relevant uses; and (c) I develop a nuanced framework for conceptualizing ancient creativity and its interrelation to human agency, politics, and social life.
Wearable sensors to measure the influence of sonic seasoning on wine consumers in a live context: a preliminary proof‐of‐concept study
Authors: Billeci Lucia , Sanmartin Chiara , Tonacci Alessandro , Taglieri Isabella , Ferroni Giuseppe , Marangoni Roberto , Venturi Francesca 
Published: March 2024

AbstractBACKGROUNDAny action capable of creating expectations about product quality would be able to modulate experienced pleasantness. In this context, during the 2022 edition of the Internet Festival (Pisa, Italy) a ‘social experiment’ was promoted to set up an affordable and reliable methodology based on wearable sensors to measure the emotions aroused in a live context on consumers by different kinds of wines. Therefore, five wines (two faulty ones and three high‐quality samples) were proposed to 50 non‐selected consumers in an arousing context with live jazz music as background. Both explicit (questionnaires) and two different approaches for implicit methods (electrocardiogram (ECG) recorded by wearable sensors vs. smartphones), the latter performed on a subgroup of 16, to measure the emotions aroused by wines and music were utilized synergistically.RESULTSAccording to our findings: (i) wine undoubtedly generates a significant emotional response on consumers; (ii) this answer is multifaceted and attributable to the quality level of the wine tasted. In fact, all things being equal, while drinking wine even untrained consumers can perfectly recognize good wines compared to products of lower quality; (iii) high‐quality wines are able to induce a spectrum of positive emotions, as observed by the analysis of ECG signals, especially when they are coupled with background music.CONCLUSIONThe framework has certainly played to the advantage of good‐quality wines, fostering their positive emotional characteristics on the palate even of some less experienced consumers, thanks to a dragging effect towards a positive mood generated by the surrounding conditions (good music in a beautiful location). © 2024 Society of Chemical Industry.
Feasibility of excitation‐emission fluorescence spectroscopy in tandem with chemometrics for quantitation of trans‐resveratrol in vine‐shoot ethanolic extracts
Authors: Caputi Antonio F , Squeo Giacomo , Sikorska Ewa , Silletti Roccangelo , Noviello Mirella , Pasqualone Antonella , Summo Carmine , Caponio Francesco 
Published: March 2024

AbstractBACKGROUNDtrans‐Resveratrol (TR) is a well‐known phytochemical compound with important biological properties. It can be recovered from agri‐food by‐products or wastes, such as vine shoots. Once recovered, its concentration should be measured, possibly in a green, non‐destructive, and efficient manner. With these premises, this work aimed to explore the feasibility of excitation‐emission fluorescence spectroscopy combined with chemometrics for the analysis of TR in raw extracts obtained from vine shoots. A total of 75 extracts were produced and analyzed by ultra‐performance liquid chromatography method with diode array detection (UPLC‐DAD) and spectrofluorimetry. Then, the feasibility of two calibration strategies for TR quantitation was assessed – a parallel factor analysis (PARAFAC)‐based calibration and the N‐way partial least squares (NPLS) regression.RESULTSThe extracts showed variable TR content, the excitation/emission maxima of which were at around 305/390 nm, respectively. The best PARAFAC‐based calibration allowed a root mean square error of prediction (RMSEP) of 22.57 mg L−1, and a relative prediction deviation (RPD) of 2.91 to be obtained but a large number of PARAFAC components should be considered to improve the predictions. The results of the NPLS regression were slightly better, with a RMSEP of 19.47 mg L−1, and an RPD of 3.33 in the best case.CONCLUSIONFluorescence could be an alternative analytical technique to measure TR in complex samples. Chemometric tools allowed the identification of the TR signal in the fluorescence landscapes, which could be further used for its non‐destructive quantitation. The need for a more accurate criterion for optimal PARAFAC complexity emerged. © 2024 Society of Chemical Industry.
Profiling flavor characteristics of cold brew coffee withGC‐MS, electronic nose and tongue: effect of roasting degrees and freeze‐drying
Authors: Zhang Donghao , Gao Min , Cai Yanpei , Wu Jihong , Lao Fei 
Published: March 2024

AbstractBACKGROUNDRoasting is an important process in the formation of coffee flavor characteristics, which determines the quality of coffee and consumer acceptance. However, the influence of roasting degree on the flavor characteristics of cold brew coffee has not been fully described.RESULTSIn the present study, the flavor characteristics of cold brew coffee with different roasting degrees were compared in detail by using chromatographic and electronic sensory approaches, and the flavor changes induced by freeze‐drying were investigated. Pyrazine and heterocyclic compounds were the main aroma compounds in coffee, and gradually dominated with the increase of roasting. Pyridine was consistently present in cold brew coffees of different roasting degrees and showed significant gradient of quantity accumulation. Aroma compounds such as pyrazine, linalool and furfuryl acetate were the main contributors to coffee roasting, floral and fruity flavor. Freeze‐drying preserved the fruity and floral aromas of medium‐roasted cold brew coffee, whereas reducing the bitterness, astringency and acidity properties that are off‐putting to consumers.CONCLUSIONThe higher consumer acceptance and enjoyment in medium roast cold brew coffee may be related to its stronger floral and fruity aroma. The aroma profile qualities of freeze‐drying processed medium roasted cold brewed coffee were more dominant and more suitable for freeze‐drying processing than medium dark roasting. Application of freeze‐drying for cold brew coffee will promote the convenience of drinking. The present study provides valuable technical guidance in improving the flavor and quality of cold brew coffee, and also promotes its commercialization process. © 2024 Society of Chemical Industry.
Does road construction have beneficial effects on vegetation biodiversity and tree regeneration in arid woodlands?
Authors: Behmanesh Soodabeh , Moradi Mostafa , Pourrezaei Javad , Basiri Reza 
Published: March 2024

AbstractThe regeneration, plant diversity, and change of soil properties are the determining factors affecting the stability of natural forests. Road construction activities are considered among the most important contributing factors. This study was conducted to see if road construction has positive or negative effects on plant diversity, soil physicochemical properties, and tree regeneration in arid woodlands and fulfill the lack of information about road construction in arid woodlands. For this purpose, two roads were selected in the arid woodlands of Bushehr Province, Iran. Twenty‐four sampling plots with an area of 200 square meters were selected on the RE and in the forest interior around the studied roads. Plant species diversity, soil physiochemical properties, and tree regeneration were determined in the studied plots. Our result indicated 49 plant species belonging to 20 families in the studied sites. RE plots represented 37 species while plots in the forest interior represented 40 species. Ficus johannis, Ziziphus spina‐christ, Eryngium billardieri, Astragalus fasciculifolius, Medicago rigidula, Vicia peregrine, and Peganum harmala appeared only in the plots located at the RE. But Dicyclophora persica, Convolvulus acanthocladus, Capparis parviflora, Pulicaria aucheri, Senecio sp., Phlomis olivieri, Teucrium polium, Ziziphora tenuior, Salvia sp., Haplophyllum canaliculatum, Fumaria parviflora, and Scabiosa olivieri appeared only in the forest interior plots. Although no significant differences were observed for richness between the RE and forest interior plots, Shannon–Wiener diversity indices revealed significant differences between the studied groups. Therefore, the composition of the plant species was not the same in the RE and forest interior plots. M. rigidula and V. peregrine as nitrogen‐fixating and palatable plant species appeared in the RE plots but not in the interior plots. Moreover, medicinal plants like D. persica and C. acanthocladus, P. aucheri, H. canaliculatum, and P. olivieri were recorded in the interior plots. Besides, the tree regeneration and soil nutrients were significantly higher in the RE plots compared to the interior plots. Overall, road construction in arid woodlands results in plant and soil community changes. Nitrogen‐fixing species appeared by providing unfavorable environmental conditions for livestock grazing at the RE. Therefore, soil nitrogen and organic matter increased, and consequently, tree regeneration increased in the RE plots. In contrast, medicinal plants appeared in the interior plots, where grazing pressure was higher than in the RE plots. Medicinal plants probably produce some chemical components unfavorable for livestock grazing.
Major depressive disorder and the risk of irritable bowel syndrome: A Mendelian randomization study
Authors: Zhu Ruiming , Zhang Nan , Zhu He , Li Fudong , Xu Hong 
Published: March 2024

AbstractBackgroundThe association between major depressive disorder (MDD) and irritable bowel syndrome (IBS) has been found in observational research; however, the causative relationship between MDD and IBS remains uncertain. Using the two‐sample Mendelian randomization (MR) approach, we attempted to examine the causal effect of MDD on IBS.MethodsIndependent genetic variants for MDD identified by Howard et al. based on a genome‐wide meta‐analysis were selected for this study. Gene‐Outcome associations for IBS were gathered from UK Biobank and FinnGen databases. The MR analysis included inverse variance weighted (IVW), MR‐Egger regression, weighted median, weighted mode, and MR‐PRESSO sensitivity analyses.ResultsFinnGen database subjected to inverse variance weighted (IVW) analysis revealed that MDD may be a risk factor for the development of IBS (OR = 1.356, 95% CI: 1.125–1.632, p = 0.0013). The same finding was reached in UK Biobank for IVW (OR = 1.011, 95% CI: 1.006–1.015, p = 3.18 × 10−7), MR‐Egger progression (OR = 1.030, 95% CI: 1.008–1.051, p = 0.007), and weighted median (OR = 1.011, 95% CI: 1.005–1.016, p = 0.0001).ConclusionOur findings supported a causal relationship between MDD and IBS, which may have implications for the clinical management of IBS in individuals with MDD.
The effectiveness and tolerability of trauma‐focused psychotherapies for psychotic symptoms: A systematic review of trauma‐focused psychotherapies
Authors: Reid Jordan , Cole Charles , Malik Nabeela , Bell Vaughan , Bloomfield Michael 
Published: March 2024

AbstractIntroductionPsychological trauma is an established risk factor for psychosis. Trauma‐focused psychotherapies (TFPT) have been suggested as a potential treatment for reducing psychotic symptoms in those who have experienced trauma. We therefore sought to investigate the effectiveness, tolerability, and acceptability of TFPT for psychotic symptoms.MethodsWe conducted a systematic review of studies of any form of TFPT that measured psychotic symptoms across a broad range of diagnoses.ResultsFrom 2584 papers initially identified, 17 studies (857 participants) met eligibility criteria. TFPT were found to be well tolerated, with very few adverse events. Acceptability was also high, with a mean dropout rate of 20%.ConclusionsWhilst the evidence of effectiveness for TFPT in reducing psychotic symptoms is weak, we found tentative evidence in favour of exposure‐based interventions. Methodologically rigorous trials investigating the efficacy of TFPT for the treatment of psychotic symptoms are needed to assess this promising intervention.
Effects of poor recruitment on riverine Smallmouth Bass population dynamics
Authors: Keplinger Brandon , Rota Christopher T. 
Published: March 2024

Abstract

Objective
Altered flow regimes pose significant risks to the stability of populations of riverine Smallmouth Bass Micropterus dolomieu. Periods of poor recruitment, due to early life stage mortality resulting from high-flow events, can cause size-structure and density alterations of populations. The aim of this study was to opportunistically test for changes in dynamic rates of a riverine Smallmouth Bass population using a long-term data set that spanned a period of poor recruitment.

Methods
Our study evaluated size-specific CPUE (fish/h), mortality, growth, and condition and tested for recruitment determinants of Smallmouth Bass through three consecutive years of poor age-0 recruitment in the South Branch Potomac River, West Virginia. We used fall nighttime boat electrofishing surveys during 2009–2022 to monitor this population before and after the poor-recruitment time frame (2016–2018).

Result
Age-0 CPUE was greater during the time frame prior to the poor-recruitment time frame. However, there was no difference in the CPUE of quality-length Smallmouth Bass between the two time frames and CPUE of preferred-length fish was greater during the poor-recruitment time frame. Growth and relative weight increased during the poor-recruitment time frame. There was no significant difference detected in mortality between the recruitment time frames. Streamflow during the spawning period was a significant factor influencing fall recruitment of age-0 Smallmouth Bass. A Ricker density-dependent model with an added streamflow term performed as well as a basic, log-linear streamflow model and a density-independent model that also incorporated a streamflow term.

Conclusion
Our results provide evidence of density-dependent structuring in this population. Decreases in population density increased population dynamic rates that maintained or improved size structure. High adult biomasses did not increase age-0 recruitment. Many riverine Smallmouth Bass populations may display favorable density-dependent responses to declines in juvenile recruitment. Thus, management agencies should better understand the resiliency of these populations prior to establishing expensive programs or regulations, which may be ineffective, to combat alterations in juvenile recruitment.