bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel UPF1 Variant Associated With a Rare UPF1‐Related Neurodevelopmental Disorder
Authors: Tümer Zeynep , Dalsberg Jonas , Rønde Gitte , Sørensen Jesper Kiehn , Østergaard Elsebet 
Published: February 2025

ABSTRACTNonsense‐mediated mRNA decay (NMD) plays a crucial role in degrading aberrant transcripts with premature termination codons, with the Up‐frameshift (UPF) protein family—UPF1, UPF2, and UPF3A/UPF3B—being vital components of this machinery. While several variants in genes encoding UPF2 and UPF3A/3B have been associated with neurodevelopmental disorders, only three germline UPF1 variants have been reported to date. Here, we report a male patient with a de novo missense variant, p.(Ala526Thr), in a highly conserved helicase motif of UPF1. The patient presented with moderate intellectual disability (ID), atypical autism, attention deficit hyperactivity disorder (ADHD), and behavioral disturbances. The common features observed among the four patients with UPF1 variants are moderate to severe ID and developmental delays in motor and verbal skills. A comparison across the disorders related to the UPF genes suggests that neurodevelopmental delay, including ID and impaired verbal skills, is a common feature, and these disorders may collectively be referred to as UPF‐related neurodevelopmental disorders (NDDs). ADHD, autism, seizures, hypotonia, and non‐specific dysmorphic features are also reported in some patients, suggesting that these disorders can be classified as non‐specific intellectual disability syndromes. However, further studies are necessary to elucidate genotype–phenotype correlations and the molecular mechanisms underlying these rare disorders, particularly those related to UPF1.
CA3 Pyramidal Neuron Activation Promotes Cognitive Resilience to Inflammation‐Induced Cognitive Inflexibility
Authors: Zuo Wenqiang , Fang Suwen , Xu Tiantian , Li Yumeng , Zhao Jianshuai , Xie Xiaoyan , Wang Taozhi , Hou Wugang , Wang Minghui 
Published: February 2025

ABSTRACTAimsCognitive dysfunction represents a prominent symptom in numerous prevalent mental illnesses, with systemic inflammation induced by cytokines recognized as a critical factor contributing to cognitive impairments. However, a significant proportion of individuals exposed to systemic inflammation do not develop cognitive dysfunction; instead, they exhibit adaptive responses to this adverse condition. This study aims to investigate the neural activity patterns within the hippocampus and the potential mechanisms that mediate cognitive resilience, particularly in the context of inflammation.MethodsWe investigated the effects of systemic IL‐1β (Interleukin‐1β) on learning, spatial memory, and cognitive flexibility using the Barnes maze test (BMT). We further analyzed specific activity changes in the hippocampus of mice exhibiting cognitive resilience versus susceptibility through immunofluorescence, fiber photometry, and behavioral assessments. Additionally, we employed chemogenetic modulation to explore the role of dCA3 pyramidal neurons in cognitive inflexibility induced by systemic inflammation.ResultsSystemic inflammation induces cognitive inflexibility while leaving learning and memory intact. Notably, dCA3 activity was elevated in cognitively resilient mice compared to their susceptible counterparts. Fiber photometry data revealed higher activity in the dorsal CA3 (dCA3) when the mice approached the previous target quadrant during the reversal stage of BMT. Importantly, the activation of CaMKII+ pyramidal neurons in the dCA3 mitigated cognitive inflexibility induced by systemic IL‐1β administration.ConclusionsActivation of hippocampal dCA3 neurons, rather than dentate gyrus (DG) neurons, enhances cognitive resilience by improving cognitive flexibility during BMT‐related paradigm shifting under sustained inflammation.
The Relationship Between the Dodd–Frank Act and the Cost Efficiency of US Banks
Authors: Minuci Eduardo G. 
Published: February 2025

ABSTRACTMotivated by the regulatory changes introduced by the Dodd–Frank Wall Street Reform and Consumer Protection Act of 2010, this study investigates its impact on the cost efficiency of US banks. Using a parametric cost frontier methodology previously linked to bank failure risk, the analysis reveals a 13% average decline in cost efficiency under the new regulatory framework. The study also examines the Act's potential heterogeneous effects across banks of different sizes, revealing that while larger banks are typically more efficient, the stricter regulatory oversight imposed on them by the Dodd–Frank Act reduced the efficiency gap with smaller banks.
Identification of Bacteria Isolated From Leaves of American Beech, Fagus grandifolia, Infested by the Foliar Nematode, Litylenchus crenatae (Nematoda: Anguinoidea), in New York, USA
Authors: Albu Sebastian , Starodumova Irina P. , Dorofeeva Lubov V. , Evtushenko Lyudmila I. , Subbotin Sergei A. 
Published: February 2025

ABSTRACTAmerican beech (Fagus grandifolia) trees exhibiting symptoms of beech leaf disease (BLD) induced by the foliar nematode, Litylenchus crenatae, were found growing in Delmar, New York, USA, in 2019. Foliar symptoms included leaf drop, galling, and darkening associated with leaf curl. Bacterial isolates were cultured from infected leaf tissue and identified to genus by 16S rRNA gene sequencing and MALDI‐TOF‐MS profiling. In addition to many taxa with putatively environmental roles, strains of the genera Agrobacterium, Curtobacterium, Pantoea, Xanthomonas, as well as Erwinia and Pseudomonas were detected. Strains of the latter two genera have been previously associated with BLD, but isolates have not yet been identified at the species level. Phylogenetic trees generated from sequences of 16S rRNA and housekeeping genes (gyrB, rpoB, and rpoD) combined with MALDI‐TOF‐MS, showed that the isolates from nematode‐infected leaves of American beech belonged to the known plant pathogenic species C. flaccumfaciens, E. billingiae, E. rhapontici, Pa. agglomerans, and X. arboricola. The species affiliation of strains showing close relatedness to A. skierniewicense, A. vaccinii, Pa. alfalfae, Pa. ananatis, Ps. amygdali, Ps. cerasi, and Ps. syringae requires further support. The identities of other bacteria isolated from the same samples are also provided.
Integrating Landscapes of Fear and Energy Reveals the Behavioural Strategies That Shape Predator–Prey Interactions
Authors: Gil Michael A. , Michel Cyril J. , Olivetti Simone , Sridharan Vamsi , Hein Andrew M. 
Published: February 2025

ABSTRACTDisparate bodies of literature implicate risk avoidance and energy conservation as important drivers of animal movement decisions. Theory posits that these phenomena interact in ecologically consequential ways, but rigorous empirical tests of this hypothesis have been hampered by data limitations. We fuse fluid dynamics, telemetry, and attack data to reconstruct risk and energy landscapes traversed by migrating juvenile salmon and their predators. We find that migrants primarily use midriver microhabitats that facilitate migration at night. During daylight, predators become more aggressive in the midriver, and prey reduce midriver use in favour of nearshore microhabitats, resulting in increased energy expenditure and decreased migration efficiency. Predators attack most when migrants are not prioritising threat avoidance and during ephemeral periods of low lighting. Our findings suggest that predator–prey interactions result from an interplay between landscapes of fear and energy, which can determine the degree to which predators affect prey through mortality or fear.
Do European Seabass Larvae Grow Better in Their Natural Temperature Regime?
Authors: Damien Crestel , Alain Vergnet , Frédéric Clota , Marie‐Odile Blanc , Théo Navarro , Stéphane Lallement , Félix Moulard , David McKenzie , François Allal , Marc Vandeputte 
Published: February 2025

ABSTRACTUnderstanding how warming surface waters impact the larval growth of highly prized marine fishes such as the European seabass, Dicentrarchus labrax, is important for sustainable fisheries and aquaculture. We studied the growth of larvae from three genetically differentiated seabass populations, Atlantic (AT), Western Mediterranean (WM), and Eastern Mediterranean (EM), reared in a common garden under three thermal regimes, representative of seasonal changes in a relatively cold Atlantic (rAT), intermediate Western Mediterranean (rWM), and warm Eastern Mediterranean (rEM). Survival was higher in warmer regimes until larvae reached a length of 23 mm, after which there was no major difference. Growth was monitored from 20 days posthatch to 1.5 g, with individuals sampled at regular intervals and their population of origin identified by parentage assignment using their genotypes for 96 SNPs. Significant length differences emerged among populations, the AT population being longer than WM and EM in all thermal regimes. In conclusion, the AT population had higher growth than the WM and EM populations in all thermal regimes, not just in its own, and the AT population can be considered the most robust to temperature variations at the larval stage. Further research is required to understand whether the high growth rate of the AT population reflects a process of local adaptation to a relatively cold thermal regime.
Periostin in Bullous Pemphigoid: A Potential Biomarker of Disease Activity and Severity
Authors: Ran Yutong , Peng Xueting , Xia Yumin , Liu Hong , Liu Yale 
Published: February 2025

ABSTRACTElevated periostin levels are commonly observed in conditions characterised by increased IgE and eosinophilia, such as bullous pemphigoid (BP), which typically presents with eosinophil infiltration and elevated IgE levels. To explore the link between periostin levels and key clinical parameters in BP, serum periostin levels were assessed in 55 classic BP patients and 55 healthy controls using ELISA. Upon admission, the BP Disease Area Index (BPDAI) score, autoantibody levels, and peripheral blood immune cells of BP patients were evaluated. The investigation also employed the Olink proteomic platform to analyse circulating proinflammatory biomarkers. The results indicated significantly higher periostin levels in BP patients, showing a strong positive correlation with BPDAI scores, which was more pronounced compared to the correlation between BPDAI scores and BP 180 IgG or eosinophil counts. Correlation analysis revealed positive links between periostin levels in serum and attributes such as urticaria/erythema lesions, total IgE levels, serum BP180 IgG, BP180 IgE, BP230 IgE, and blood eosinophil counts. The findings from the Olink proteomic analysis provided additional evidence of the connection between periostin and type II inflammation in BP, which was further validated by the observed positive correlation between periostin and IL‐13 using ELISA. Furthermore, it was observed that serum periostin levels decreased post‐effective treatment. Overall, this study underscores a compelling association between periostin expression and the activity and severity of BP, as well as its reflection of type II inflammation.
A Systematic Review on Text Summarization: Techniques, Challenges, Opportunities
Authors: Sharma Kanta Prasad , Yajid Mohd Shukri Ab , Gowrishankar J. , Mahajan Rohini , Alsoud Anas Ratib , Jadhav Abhilasha , Singh Devendra 
Published: February 2025

ABSTRACTText Summarization (TS) is a technique for condensing lengthy text passages. The objective of text summarization is to make concise and coherent summaries that contain the main ideas from a document. When thinking about a page or watching a video, researchers or readers might imagine an abbreviated version which will just catch important parts only. This paper provides an overview of research work done by different authors on this field. There are numerous machine learning and deep learning‐based approaches and methods for implementing text summarization in practice because of several factors like time saving, increased productivity, effective comparative analysis, among others. In this article we explore the concept of text summarization as well as techniques, general framework, applications, evaluation measures within both Indic and Non‐Indic scripts. Additionally, the article brings out some related issues between text summarization and other intelligent systems such as script nature datasets architectures latest works, and so forth. Finally, the authors presented the challenges of text summarization, as well as analytical ideas, conclusions, and future directions for text summarization.
Beyond collectivism and individualism: Chinese international students' perceptions of contemporary child‐centered parenting
Authors: Liu Jiayi , Huang Qi , Park Hye‐Jin , Qin Desiree B. 
Published: February 2025

AbstractObjectiveThis study explores the presence and cultural underpinnings of child‐centered parenting practices as perceived by Chinese international students from urban, only‐child Chinese families.BackgroundResearch indicates that contemporary urban Chinese families are experiencing a shift in parenting practices from family centered to child centered. However, existing construal of child‐centered parenting primarily relies on Western theories, lacking consideration of Chinese cultural values. There is also a need to comprehend youth interpretations of child‐centered parenting to understand its influence on children's development.MethodWe conducted interviews with 30 first‐year Chinese international students in the United States (16 female, 14 male) about their experiences within the family context since childhood. Thematic analysis was employed.ResultsOur analysis demonstrated the presence of child‐centered parenting in urban Chinese families and revealed socialization goals and four interlinked practices: (a) guiding, (b) nurturing, (c) supporting inclusive autonomy, and (d) investing in education. Three themes were identified regarding youths' mixed perceptions of child‐centered parenting.ConclusionChinese society's transitional nature contributes to a combination of individualistic socialization goals and collectivistic practices. Youths generally perceive child‐centered parenting positively but feel overwhelmed and obligated in some circumstances.ImplicationsPractitioners should incorporate both traditional and Western cultural values in developing parenting programs.
Acoustic Emission‐Based Damage Pattern Identification and Residual Strength Prediction of Glass‐Fiber Reinforced Polymers
Authors: Xu Xiheng , Bi Xinyu , Li Zhuohan , You Yiliang 
Published: February 2025

ABSTRACTIn this paper, the damage mechanisms and residual strength prediction models of unidirectional glass‐fiber reinforced polymers are investigated by acoustic emission (AE) technique. The material exhibits three damage modes: matrix cracking, fiber fracture, and interface damage. A novel AE descriptor, amplitude/centroid frequency (ACF), is introduced to differentiate interface damage from other damage modes. Moreover, the clustering analysis results are used as a training set for K‐nearest neighbor (KNN) and support vector machine (SVM) methods to realize real‐time classification. Prediction of residual strength of materials after pre‐fatigue is achieved by introducing AE cumulative counts into two regression analysis prediction models. Additionally, optimization of prediction results can be achieved by a certain kind of signals after clustering. The combination of AE and machine learning can realize real‐time residual strength prediction.
Soil Organic Carbon Storage of Different Soil‐Sized Fractions in Perennial Bioenergy Crops on Marginally Productive Cropland in Southern Canada
Authors: Osei Augustine K. , Thevathasan Naresh V. , Oelbermann Maren 
Published: February 2025

ABSTRACTUnderstanding carbon (C) storage in different soil‐sized fractions of perennial bioenergy crops enhances our knowledge of how these crops contribute to long‐term soil organic carbon (SOC) storage, with positive implications for mitigating climate change through C sequestration. However, the extent to which perennial bioenergy crops contribute C in different soil‐sized fractions remains unclear. Hence, this study investigated SOC contents under perennial bioenergy crops of Miscanthus (Miscanthus × giganteus L.), willow (Salix miyabeana L.), switchgrass (Panicum virgatum L.), and a successional site. We also quantified the C contribution of the bioenergy crops to different soil‐sized fractions using the δ13C natural abundance technique. After 12 years of cultivation, SOC contents to 30 cm depth increased by 2.5% and 3.1% in willow and Miscanthus, respectively, but decreased by 3.7% in switchgrass compared to baseline SOC data. SOC stocks ranged from 5686 to 7002 g C m−2 and were higher (p ≤ 0.050) in the successional site compared to switchgrass and willow, but not Miscanthus. Unlike switchgrass and willow, Miscanthus maintained SOC stocks comparable to the successional site even with annual biomass harvest. This implies that the ability of perennial bioenergy crops to influence SOC storage similar to regrowth vegetation on marginally productive cropland depends significantly on the crop species. Additionally, Miscanthus contained higher (p ≤ 0.013) SOC in micro‐sized and silt + clay fractions at 20–30 cm depth compared to the 0–10 and 10–20 cm depths and contributed the most C in all three soil‐sized fractions compared to switchgrass and willow. Our findings suggest that among the three bioenergy crops, Miscanthus has the greatest potential for long‐term C storage and stabilization in deeper soil depths on marginally productive croplands. This holds true even with annual biomass harvesting and the absence of fertilization, making Miscanthus a valuable contributor to climate change mitigation.
Impact of training healthcare professionals in the detection and management of neuropsychiatric comorbidities in people with HIV: The CONECTAR project in Spain
Authors: Blanch Jordi , Martinez Esteban , Mena Álvaro , Dueñas Carlos , Bernal Enrique , Cabello Alfonso , Hayek Marcelino , Mican Rafael , Morillo‐Verdugo Ramón , Sainz María , Conde Cristina González , Perez‐Valero Ignacio 
Published: February 2025

AbstractIntroductionAlthough anxiety, depression and insomnia in people with HIV (PWH) are prevalent and have a major impact on clinical outcomes and quality of life, physicians fail to evaluate them routinely. The CONECTAR Project [Neuropsychiatric Comorbidity (NPC): Key to Antiretroviral Treatment] aimed to improve NPC clinical care in PWH in Spain by upskilling healthcare professionals (HCPs).MethodsA group of HCPs developed a training programme, supported by national and international guidelines, to improve expertise on detecting and managing NPCs in PWH. The programme was conducted through workshops for physicians and nurses in various Spanish regions from April to November 2023; survey questionnaires were administered to physicians before the commencement of training and 15 days after. Later, a workshop was held for nurses who manage NPCs in PWH.ResultsThe programme was completed by 64 physicians (22 had completed both questionnaires) and 11 nurses (no feedback obtained). Feedback from physicians reflected that the programme boosted awareness and self‐perception of being more qualified, knowledgeable and able to use management tools and resources. Physicians also reported improved perception of time available for visits and more frequent enquiries about patients' NPC symptoms. Despite their satisfaction with the workshops, half of the physicians recognized the need for more training.ConclusionThe CONECTAR Project was a successful training programme that was well received and valued by HCPs who routinely manage NPCs in PWH. Institutions involved in HCP training to manage anxiety, depression and insomnia more effectively in PWH should consider similar proposals to reinforce clinical practices.
Workplace Violence Against Chinese Nurses From the Perspectives of Social Media and News Reports: A Multilayer Text Mining Analysis
Authors: Cao Yucheng , Gao Yu , Chappell Kathy 
Published: February 2025

ABSTRACTAimsThis study compares the emotional expressions and structural characteristics of workplace violence (WPV) against Chinese nurses in social media comments and news reports, highlighting differences and focal points in dissemination.DesignA quantitative study utilising text mining and social network analysis.MethodsData containing the keywords ‘nurse violence’, ‘nurse workplace violence’, ‘nurse bullying’, ‘nurse workplace bullying’ were collected from social media platforms (e.g., Xiaohongshu, Zhihu, Weibo) and news platforms (e.g., Baidu News, People's Daily, Xinhua News) between January 1, 2016, and October 31, 2024. Using Python 3.8.9, time trends and sentiment analyses were performed, while Ucinet 6.0 was used for social network analysis to explore dissemination patterns and keyword structures. A total of 5431 social media comments and 89 news reports were analysed.ResultsTemporal analysis showed that social media attention to WPV against nurses significantly exceeded that of news reports, with a peak in 2024. Sentiment analysis revealed predominantly negative emotions (52.75%) on social media, while news reports exhibited a more positive tone (62.92%). Social network analysis revealed stark differences in keyword structures between platforms. Social media exhibited a dense and decentralised network, with keywords like ‘head nurse’, ‘leader’ and ‘bullying’ highlighting internal professional conflicts. In contrast, news reports showed a centralised network focusing on external violent incidents, with keywords such as ‘violence’, ‘assault’ and ‘patient’ dominating.ConclusionsSocial media and news reports demonstrated significant differences in describing WPV against nurses. Social media focused on emotional expressions of interpersonal conflicts, whereas news reports prioritised factual accounts of violent incidents and proposed solutions.ImpactThis study offers insights into how WPV against nurses is communicated through different media, helping nursing administrators and policymakers understand the complexity of these narratives. The findings can inform the development of targeted communication strategies to address WPV and enhance public awareness.Patient or Public ContributionNot applicable.