bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of operation on cell‐mediated immune response to autologous tumor extract in cancer patients
Authors: Miyazaki Soichiro , Akiyoshi Tsuyoshi , Kawaguchi Michihiro , Koba Fumio , Arinaga Shinya , Wada Tetsuya , Tsuji Hideo 
Published: February 2007

AbstractUtilizing lymphocyte proliferation assay, effects of operation on cell‐mediated immune response to autologous tumor extract were studied in 33 patients with gastric or colon carcinoma. To evaluate the lymphocyte proliferation response to autologous tissue extract preoperatively, the lymphocytes were left in culture for 24–30 hours before addition of the extract while 3 M KC1 extract of autologous tissue was being processed. A significant level (P < 0.001) of correlation was observed between stimulation index values to autologous tumor extract added at the initiation of culture and after a 24–30–hour period of incubation. Using this type of assay system, lymphocyte proliferation response to autologous tumor extract was examined immediately before operation and 1, 2, and 4 weeks after operation serially. Data comparing the responses of 20 patients who had curative resection and 13 patients who underwent noncurative resection appeared to fall into three categories in each group. The clinical courses of these patients in each category might clarify the significance of changes in the response following operation.
Choice of operative procedure for adenocarcinoma of the gastric antrum: A study based on TNM classification
Authors: Papachristou Dimitrios N. , Fortner Joseph G. 
Published: February 2007

AbstractThis is a retrospective study comparing the results of distal subtotal (DST), total (T), and extended total (ET) gastrectomy in a group of 143 patients with adenocarcinomas of the antrum. Of those, 52 had TNM stage I and II tumors and 91 had stage II and IV tumors. Operative mortality was 10% with DST, 23% with T, and 16% with ET. The incidence of recurrence of the tumor at the gastrectomy site was 26% for DST, 27% for T, and only 9% for ET. In stages I and II, the difference of recurrence in favor of ET was significant (P < 0.05). Analysis of survival data without TNM staging showed no significant difference between the three procedures. TNM staging indicated that that surgical treatment, regardless of procedure, salvaged only five out of 91 stage III and IV patients. The choice of procedure made a difference only in stages I and II, where ET was associated with a significantly higher survival than DST (P < 0.02). The study suggested that intraoperative staging might be of value in selecting the proper type of gastrectomy. This could be accomplished with node sampling because tumor size corresponds poorly with TNM stage.
Primary procedure in carcinoma of the tongue: Local resection versus combined local resection and radical neck dissection
Authors: Ferrara John , Beaver Bonnie L. , Young Donn , James Arthur G. 
Published: February 2007

AbstractWhether to perform local resection alone (LR) or to combine local resection with ipsilateral radical neck dissection (LR and RND) as primary treatment for carcinoma clinically confined to the tongue is controversial. To compare the outcomes of the two procedures, we reviewed the records of 502 patients treated for carcinoma of the tongue from 1949 to 1974, 128 of whom had no evidence of disease beyond the tongue. Immediate LR and RND was performed in 39; 16 (41%) had recurrences, and 14 (36%) died. On the other hand, 89 patients underwent LR alone; 43 (48%) had recurrences, and 29 (31%) died. All were followed for a minimum of 5 years or until their deaths. There was no statistical difference between the two procedures in recurrence or outcome. The two groups were compared with respect to tumor size according to the TNM classification, and no significant differences in recurrence or survival were apparent. LR alone appears to be adequate primary treatment for patients with no evidence of metastatic disease, provided close postoperative follow‐up is observed. LR and RND may result in increased morbidity and certainly in disfigurement, and fails to improve prognosis or survival.
Intermittent hemodialysis therapy in the cancer patient
Authors: Beckley Sunmolu , Wajsman Lew Z. , Pontes J. Edson , Major Alice , Murphy Gerald P. 
Published: February 2007

AbstractThe occurrence of renal failure in the cancer patient presents a series of medical, technical, philosophical, and logistic problems that are rarely found in other patient population groups. In a review of 70 cancer patients requiring intermittent hemodialysis therapy at Roswell Park Memorial Institute over the last 6 years for acute renal failure, 46 (65.7%) of the patients were salvaged from renal failure to allow the use of further therapeutic modalities for their neoplastic disease. Patient survival after successful intermittent hemodialysis therapy was comparable to that expected in the nonazotemic cancer patients submitted to similar anticancer therapy. Hemodialysis should, therefore, be considered and offered in selected cancer patients in acute renal failure.
Benign mesenchymoma of the chest wall in infancy
Authors: Campbell A. N. , Wagget J. , Mott M. G. 
Published: February 2007

AbstractChest wall mesenchymoma is a rare tumour in childhood and often presents in the neonatal period. In the past all patients have received surgical treatment with quite a high morbidity. We present here three further cases that presented in infancy, two of which received minimal therapy with good results in each case. We would propose from these cases that once the diagnosis has been established by biopsy that total surgical resection not be carried out unless cardiac or respiratory embarrassment is present.
Plasma hormone responses to tamoxifen therapy and oophorectomy
Authors: Al‐Jurf Adel S. 
Published: February 2007

AbstractThe effect of tamoxifen therapy on plasma hormones in the pre‐ and post‐menopausal state was studied in a young patient with breast cancer. Tamoxifen therapy was carried out for metastatic disease prior to (premenopausal) and after oophorectomy (surgical menopause). Changes in luteinizing hormone, follicle‐stimulating hormone, prolactin, and estrogen were noted and were corroborated with the therapy or oophorectomy. The findings support some of the previously reported changes in those hormones that were noted in conjunction with tamoxifen therapy.
Suppressor cells and increased primary tumor growth rate induced by thiopental
Authors: Lovett Edmund J. , Varani James , Lundy Joel 
Published: February 2007

AbstractA single dose of thiopental (37‐42 mg/kg) sufficient to achieve anesthesia induction increased the growth rate of a 3‐methylcholanthrene‐induced syngeneic murine fibrosarcoma in C57B1/6 mice. While no alterationsin in vitro growth kinetics of tumor cells cultured with thiopental could explain these data, significant alterations in cell‐mediated immunity were observed. Spleen cells from C57B1/6 mice treated with thiopental were impaired in their ability to respond in a mixed leukocyte culture (MLC) to BALB/c stimulator cells. Spleen cells from thiopental‐treated mice suppressed the ability of cells from untreated animals to respond in a third‐party MLC. The degree of suppression was directly proportional to the number of cells from thiopentaltreated mice in the third party. When these cells were added to an MLC at various times during the culture period, suppression of the early phases of the MLC was seen. Removal of plastic adherent cells from the third party resulted in loss of suppression, but treatment of third‐party cells with anti‐thy 1.2 serum or irradiation did not prevent suppression. Transfer of spleen cells from thiopental‐treated mice enhances growth of the B‐16 melanoma. Suppressor‐cell activity may be one mechanism by which thiopental promotes tumor growth.
Retroperitoneal urogenital ridge transitional cell carcinoma
Authors: Gupta S. , Gupta S. , Sahni K. 
Published: February 2007

AbstractA rare case of retroperitoneal transitional cell carcinoma arising from primitive urogenital remnants is described in a 50‐year‐old female. The patient had a 15 × 12 cm firm to cystic mass in the left iliac fossa which was markedly adherent to retroperitoneal structures and which could not be excised. Biopsy from the mass revealed transitional cell papillary carcinoma. Intravenous pyelogram and cystoscopy were normal. Cystogram done postoperatively did not show any communication with any adult organ. Radiotherapy resulted in only partial regression, and the patient died about 2 years later.
Patterns of failure following surgery alone for colorectal carcinoma
Authors: Chung C. K. , Stryker John A. , Demuth William E. 
Published: February 2007

AbstractTwo hundred fifty‐one patients with colorectal carcinoma were studied following complete primary resection to determine patterns of failure. Seventy‐two patients (29%) subsequently developed failures: Local failure (LF) occurred as the only failure in 49% of the failure group and as some component in 81%; distant metastases (DM) occurred in 19% and 47%, respectively.The groups at highest risk for local failure were those with extension of tumor through the bowel wall whether the nodes were involved or not. Furthermore, those with gross extension of disease through the wall developed a significantly higher incidence of distant metastases compared to those with microscopic extension through the wall (P < 0.005). The absolute 5‐year survival rate for those with tumor through the wall vs within the wall was 40% and 79%, respectively.Adjuvant therapy was discussed in view of the ability to identify subgroups of patients at highest risk for local vs distant failures.
Macrophage‐mediated tumor cytotoxicity: Role of macrophage surface sialic acid
Authors: Cameron Deborah J. 
Published: February 2007

AbstractCell surface sialic acid levels were compared for monocytes and macrophages obtained from normal volunteers and breast cancer patients. Equal quantities of sialic acid were found on the monoscytes obtained from normal volunteers and breast cancer patients. Approximately 60% more cell surface sialic acid was found on the macrophages from breast cancer patients than was found on the macrophages from normal volunteers. In order to determine whether cell surface sialic acid had any effect on macrophage‐mediated cytotoxicity, macrophages were pretreated with neuraminidase (NANAse) prior to co‐cultivation with tumor cells. The normal macrophages, after neuraminidase treatment, no longer retained their ability to kill tumor cells. However, when macrophages from breast cancer patients were treated with NANAse, no difference was observed in the ability of untreated and NANAse treated macrophages to kill tumor cells.
Squamous cell carcinoma of the renal pelvis as a late complication of hepatic irradiation: A case report
Authors: Weshler Zeev , Sulkes Aaron , Kopolovic Juri 
Published: February 2007

AbstractA patient was treated with radiation therapy to the right hemiabdomen for a large cavernous hemangioma of the liver. Twenty years later, a squamous cell carcinoma of the right renal pelvis was diagnosed. The occurence of such a tumor as a late complication of irradiation has not been described before.
Exfoliative cytology and biliary biopsy using a percutaneous transhepatic biliary tube
Authors: Okamura Jun , Monden Morito , Horikawa Shinichi , Gotoh Mitsukazu , Kosaki Goro , Kuroda Chikazumi , Sakurai Masami 
Published: February 2007

AbstractPercutaneous transhepatic biliary cytology and biopsy was carried out in 19 patients with a malignancy‐related jaundice, using a percutaneous transhepatic biliary tube. The preoperative diagnosis was positive in 17 patients (89%). This simple and safe method will facilitate operative procedures, diagnosis, and palliative chemotherapy regimens.
Measurement of progesterone receptor in human renal cell carcinoma and normal renal tissue
Authors: McDonald Michael W. , Diokno Ananias C. , Seski Jan C. , Menon K. M. J. 
Published: February 2007

AbstractProgesterone receptor was measured in eight samples of renal cell carcinoma, nine samples of normal renal tissue, and one sample of melanoma tissue. Progesterone receptor was identified in all samples, with the exception of one renal cell carcinoma. Three patients, all with receptor‐positive tumors, were treated with medroxyprogesterone acetate for metastatic disease. In one of these patients there was a partial objective response to treatment. Further research regarding progesterone receptor in renal cell carcinoma is indicated.
A rationale for surgical detection of cancer without hospitalization
Authors: Azzarelli Alberto , Quagliuolo Vittorio , Menotti Velio , Pietro Sergio Di 
Published: February 2007

AbstractDuring 1980, in strict accordance with indication schedules outlined for breast, skin, oral cavity, lymph node, and soft tissue lesions, 2,499 patients were selected and operated on in the outpatient department of our institution. The main purpose was early detection of unexpected cancer without hospitalization. Of 1,266 breast operations, 99 (7.8%) unexpected carcinomas and 67 (5.3%) borderline or precancerous lesions were detected, with a higher rate of T1 and N—cases than were found in hospitalized breast carcinoma patients: Tl, 61% vs 38%; N—, 68% vs 54%. The specimens of 1,048 skin and oral cavity lesions revealed 261 (24.9%) squamous or basal cell carcinomas, and most of them were cured by the outpatient surgery itself. Removal of 149 suspicious nevi revealed 20 (13.4%) unexpected malignant melanomas; 185 operations on lymph node and soft tissues detected 44 lymphomas (31 unexpected), 36 metastatic lymph nodes (five unexpected), and six sarcomas (five unexpected). These data confirm the validity of and necessity for surgical outpatient operations in selected cases.
Leucocyte adherence inhibition and carcinoembryonic antigen in combination for diagnosis of colorectal cancer
Authors: Payne J. E. , Dent O. , Chapuis P. H. , Meyer H. J. , Sutherland M. A. , Ruwoldt A. 
Published: February 2007

AbstractA combination of leucocyte adherence (LAI) and carcinoembryonic antigen (CEA) diagnosed colorectal carcinoma with 91% sensitivity and 68% specificity. Relative operating characteristic (ROC) analysis was used to calculate the cutoff points for optimum detectability in a group of 159 patients with bowel symptoms who were investigated by endoscopy and radiology. Combining LAI and CEA would be likely to reduce the chance of missed diagnosis of colorectal carcinoma when x‐ray and colonoscopic findings are equivocal.
Skip metastases in osteosarcoma: Recent experience
Authors: Malawer Martin M. , Dunham William K. 
Published: February 2007

AbstractOsteosarcoma associated with a skip metastasis (SM) is a rare occurrence. The impact of modern chemotherapy on this entity has not been previously reported. This paper presents three cases treated by primary amputation and postoperative chemotherapy. All patients developed typical pulmonary and subsequent bony metastases. The average disease‐free interval was 6.7 months. None appeared to benefit either from intensive chemotherapy or thoracotomy. The disease disseminated extensively in all three patients without radiologic or clinical response to the varied chemotherapeutic or additional surgical procedures. We conclude that a SM is a grave prognostic sign despite modern adjuvant modalities and suggest that a different therapeutic strategy is required.
Preoperative chemotherapy followed by mastectomy for locally advanced breast cancer
Authors: Schick Peter , Goodstein Jordan , Moor John , Butler John , Senter Kenneth L. 
Published: February 2007

AbstractSix patients with advanced local‐regional breast cancer were reviewed. Five out of the six patients previously had had radiation therapy as part of the initial therapy. All patients had preoperative cycles of combination chemotherapy, either CMF or CAF. The two stage III patients had greater than 75% reduction in measurable tumor mass, which allowed a conventional modified radical or radical mastectomy to be performed. Both of these patients are now disease free at 26 and 27 months. The four stage IV patients had lesser operations following the chemotherapy (two simple mastectomies, one simple mastectomy plus axillary resection, and one axillary debulking). Reconstruction utilized advancement flaps in three patients and split‐thickness skin grafts in the other. None of the patients had postoperative wound problems, and none of the patients had further problems with local cancer control. All patients had combination chemotherapy starting two to six weeks following surgery. Preoperative chemotherapy followed by surgery plays an important role in management of locally advanced stage III and stage IV breast cancer.
Fibrosarcoma associated with intensive chemotherapy for advanced germ cell testicular tumor
Authors: Klein Frederick A. , Herr Harry W. , Vugrin Davor 
Published: February 2007

AbstractA case is presented in which an abdominal low grade fibrosarcoma developed 4 years after completion of a 3‐year therapeutic regimen of intensive combination therapy for a metastatic nonseminomatous germ cell tumor of the testis.
Immune RNA therapy as an effective adjuvant immunotherapy after surgery: An animal model
Authors: Aarons Scott , Krishnan Engikolai C. , Mebust Winston K. , Jewell William R. 
Published: February 2007

AbstractTransfer of tumor immunity as adjuvant cancer therapy has been a topic of intense interest. We have examined the efficacy of various combinations of surgery, xenogeneic immune RNA, xenogeneic normal RNA, tumor vaccine, and nonspecific splenocytes as adjuvant therapy for B16 melanoma in the C57BL/6J mouse system. B16 melanoma was transplanted by trocar into the right hind limb of 6‐week‐old mice. The tumors were readily palpable on the ninth day posttransplantation. The tumors were amputated at that time under mild anesthesia. Immune RNA was prepared by hot phenol extraction from immune sheep spleens. Various combinations of immune RNA, normal RNA, and tumor antigen, with or without normal mouse spleen cells, were administered every other day for a total of 10 injections. The survival and mode of death was followed up to 120 days. All mice without any treatment died within 30 days. Immunotherapy had no effect on the survival of mice that did not have surgical therapy. Individual group comparisons between mice that underwent surgery only and mice that had surgery plus immune RNA immunotherapy revealed a striking statistical improvement (P < 0.01). Comparing all groups that received amputation plus various combinations of adjuvant immunotherapy showed no statistical difference in survival. However, immune RNA appears somewhat superior to normal RNA or antigen only. It appears that adjuvant immune RNA immunotherapy following surgical excision in the B16 melanoma model significantly improves survival and retards the spread of metastases.
Extraskeletal Ewings sarcoma
Authors: Chen Karl T. K. , Padmanabhan A. 
Published: February 2007

AbstractA case of Ewings sarcoma arising in the soft tissue of the thumb is described. This appears to be the first case of digital extraskeletal Ewings sarcoma. The soft tissue location, the primary rather than metastatic nature, and the tumor type in this case were well documented.
Anaplastic transformation of thyroid cancer: Report of two cases and review of the literature
Authors: Mooradian Arshag D. , Allam Charles K. , Khalil Maryse F. , Salti Ibrahim , Salem Philip A. 
Published: February 2007

AbstractTransformation of well‐differentiated thyroid adenocarcinoma to anaplastic cancer has been occasionally reported. Two new cases of such transformation are now described. The time interval from diagnosis to the development of anaplastic cancer was 15 years in the first patient and 10 years in the second. Both patients ultimately developed extensive bilateral pulmonary metastases and died within 6 months from the diagnosis of the transformation. Hypotheses concerning the pathogenesis of the transformation and the literature were reviewed. We believe that histopathological confirmation of recurrent and rapidly progressive thyroid tumors is necessary prior to initiation of therapy.
Blood flow in human tumors during hyperthermia therapy: Demonstration of vasoregulation and an applicable physiological model
Authors: Olch Arthur J. , Kaiser Larry R. , Silberman Allan W. , Storm F. Kristian , Graham L. Stephan , Morton Donald L. 
Published: February 2007

AbstractA quantitative assessment of the effect of localized magnetic‐loop hyperthermia on blood flow was performed in 12 human tumors using the133Xe clearance method. Because blood flow in these tumors changed in response to needle injection, a physiologically based, one‐compartment model was developed that included both a hyperemic and a steady‐state component. In six tumors, changes in blood flow induced by heat were also observed. The ability of tumor vessels to respond dynamically to stress and the degree of response may be predictive of tumor heating capacity and subsequent therapeutic response.
The addition of chemotherapy to hormonal therapy for treatment of patients with metastatic carcinoma of the prostate
Authors: Gibbons R. P. , Beckley S. , Brady M. F. , Chu T. M. , Dekernion J. B. , Dhabuwala C. , Gaeta J. F. , Loening S. A. , McKiel C. F. , McLeod D. G. , Pontes J. E. , Prout G. R. , Scardino P. T. , Schlegel J. U. , Schmidt J. D. , Scott W. W. , Slack N. H. , Soloway M. S. , Murphy G. P. 
Published: February 2007

AbstractPatients with advanced prostate carcinoma that had been stabilized by orchiectomy (ORCH) or hormone therapy for at least 3 months, were randomized to either diethylstilbestrol (DES) alone or DES plus Cytoxan or DES plus Emcyt. A total of 188 patients were randomized between July, 1976 and February, 1982 of which 161 were evaluable for objective response to treatment. Objective response rates, response duration, or survival experiences were not demonstrably different between treatment arms, either for all patients or within good or poor prognosis groups determined by initial pain or acid phosphatase level. Subjective improvements in performance status were small for each treatment. Pain relief was somewhat greater in the chemotherapy‐hormone combinations than in the DES/ORCH, but the advantage was not statistically significant. Side effects were primarily nausea and vomiting and leukopenia, mostly in the DES + Cytoxan arm. The duration of stabilization prior to entry did not influence response overall, although there were opposing trends within each of the two chemotherapy arms. The premise for combining antitumor agents with hormones before hormone failure is still felt to be a more logical approach than waiting for the ultimate hormone failure, and a combination of hormones plus two antitumor agents is being evaluated in a subsequent ongoing trial where a more rigid design limits the duration of the preentry period of hormone stabilization.
Latent childhood thyroid carcinoma in diffuse lymphocytic thyroiditis
Authors: Siegal A. , Mimouni M. , Kovalivker M. , Griffel B. 
Published: February 2007

AbstractDiffuse thyroid enlargement in a child is a rare presenting symptom of thyroid carcinoma. A papillary carcinoma may be hidden in a diffuse lymphocytic thyroiditis and should be carefully searched for during surgery. Furthermore, the finding, in frozen sections, of psammoma bodies in a lymphocytic thyroiditis should raise the suspicion of an occult malignant neoplasm. A case illustrating these diagnostic difficulties in a 5‐year‐old child is presented.