bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progressive Impairment of Prepubertal Growth in Children With APECED
Authors: Saari Viivi , Alanko Venla , Holopainen Elina , Mäkitie Outi , Laakso Saila 
Published: April 2024

Abstract

Context
Subjects with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) have subnormal adult height. There are several potential APECED-related risk factors for suboptimal height attainment during childhood.

Objective
To determine the growth patterns in children with APECED.

Methods
This retrospective longitudinal study included 59 children with APECED from the Finnish national APECED cohort and assessed length/height and weight z-scores from birth to the end of prepuberty.

Results
Collectively, 59 children (30 [51%] girls) were included. Their median birth weight z-score (−0.60) was below the population average; 12 (20%) patients were born small for gestational age. Height attainment progressively declined from birth until the end of prepuberty (z-score −1.95), whereas weight-for-height z-score did not (+0.26). Of the 59 patients, 38 (64%) had all height z-scores below 0 during prepuberty, and 7 (12%) had z-scores below −2.0. Age at the end of prepuberty, number of APECED manifestations, duration of glucocorticoid treatment, and growth hormone deficiency correlated negatively with height z-score at the end of prepuberty (P &lt; .0001; P = .041; P = .013; P = .034, respectively).

Conclusion
Children with APECED had a progressive growth impairment from birth through prepuberty. Multiple predisposing risk factors were recognized, including disease severity and growth hormone deficiency. Timely interventions are needed to ensure optimal height attainment and new treatment options need to be developed.
A 2023 International Survey of Clinical Practice Patterns in the Management of Graves Disease: A Decade of Change
Authors: Villagelin Danilo , Cooper David S , Burch Henry B 
Published: April 2024

Abstract

Context
Over the past several decades, there have been indications of potential shifts in the diagnostic strategies, treatment, and monitoring of patients with Graves disease (GD).

Objective
To evaluate current practices in managing GD and compare them to previous surveys

Methods
We used a global online survey of endocrinologists to assess shifts in the diagnosis, monitoring, and treatment in a typical patient with GD, as well as treatment variation in 5 different clinical scenarios.

Results
A total of 1252 respondents from 85 countries completed the survey. Methods used to diagnose an uncomplicated GD case have changed over the past decade, reflecting increased use of thyrotropin receptor antibody (TRAb) and reciprocal decreases in nuclear medicine studies. The preferred mode of therapy for uncomplicated GD was antithyroid drugs (ATDs) by 91.5% of respondents, radioactive iodine (RAI) therapy by 7%, and thyroidectomy by 1.5%. Compared with previous surveys, the use of RAI as a first-line choice decreased in all geographic regions. The United States had the sharpest decline in the selection of initial therapy with RAI, decreasing from 69% in 1990 to 11.1% in 2023. In patients with persistent TRAb positivity after 18 months, 68.7% of respondents would continue the use of ATDs. After a relapse of GD, resumption of ATDs was selected by 59.9% of respondents. In patients with active thyroid eye disease or planning pregnancy, ATDs were the first choice (67.5% and 72.8%, respectively), and thyroidectomy emerged as the second choice (22.9% and 15.6%, respectively).

Conclusion
Paradigm shifts have occurred in the management of uncomplicated GD and its variants, as well as the response to persistent and recurrent hyperthyroidism.
β-Cell Insulin Resistance Plays a Causal Role in Fat-Induced β-Cell Dysfunction In Vitro and In Vivo
Authors: Ivovic Aleksandar , Yung Justin Hou Ming , Oprescu Andrei I , Vlavcheski Filip , Mori Yusaku , Rahman S M Niazur , Ye Wenyue , Eversley Judith A , Wheeler Michael B , Woo Minna , Tsiani Evangelia , Giacca Adria 
Published: April 2024

Abstract
In the classical insulin target tissues of liver, muscle, and adipose tissue, chronically elevated levels of free fatty acids (FFA) impair insulin signaling. Insulin signaling molecules are also present in β-cells where they play a role in β-cell function. Therefore, inhibition of the insulin/insulin-like growth factor 1 pathway may be involved in fat-induced β-cell dysfunction. To address the role of β-cell insulin resistance in FFA-induced β-cell dysfunction we co-infused bisperoxovanadate (BPV) with oleate or olive oil for 48 hours in rats. BPV, a tyrosine phosphatase inhibitor, acts as an insulin mimetic and is devoid of any antioxidant effect that could prevent β-cell dysfunction, unlike most insulin sensitizers. Following fat infusion, rats either underwent hyperglycemic clamps for assessment of β-cell function in vivo or islets were isolated for ex vivo assessment of glucose-stimulated insulin secretion (GSIS). We also incubated islets with oleate or palmitate and BPV for in vitro assessment of GSIS and Akt (protein kinase B) phosphorylation. Next, mice with β-cell specific deletion of PTEN (phosphatase and tensin homolog; negative regulator of insulin signaling) and littermate controls were infused with oleate for 48 hours, followed by hyperglycemic clamps or ex vivo evaluation of GSIS. In rat experiments, BPV protected against fat-induced impairment of β-cell function in vivo, ex vivo, and in vitro. In mice, β-cell specific deletion of PTEN protected against oleate-induced β-cell dysfunction in vivo and ex vivo. These data support the hypothesis that β-cell insulin resistance plays a causal role in FFA-induced β-cell dysfunction.
Collapse of late endosomal pH elicits a rapid Rab7 response via the V-ATPase and RILP
Authors: Mulligan Ryan J. , Magaj Magdalena M. , Digilio Laura , Redemann Stefanie , Yap Chan Choo , Winckler Bettina 
Published: April 2024

ABSTRACT
Endosomal-lysosomal trafficking is accompanied by the acidification of endosomal compartments by the H+-V-ATPase to reach low lysosomal pH. Disruption of the correct pH impairs lysosomal function and the balance of protein synthesis and degradation (proteostasis). Here, we treated mammalian cells with the small dipeptide LLOMe, which is known to permeabilize lysosomal membranes, and find that LLOMe also impacts late endosomes (LEs) by neutralizing their pH without causing membrane permeabilization. We show that LLOMe leads to hyperactivation of Rab7 (herein referring to Rab7a), and disruption of tubulation and mannose-6-phosphate receptor (CI-M6PR; also known as IGF2R) recycling on pH-neutralized LEs. pH neutralization (NH4Cl) and expression of Rab7 hyperactive mutants alone can both phenocopy the alterations in tubulation and CI-M6PR trafficking. Mechanistically, pH neutralization increases the assembly of the V1G1 subunit (encoded by ATP6V1G1) of the V-ATPase on endosomal membranes, which stabilizes GTP-bound Rab7 via RILP, a known interactor of Rab7 and V1G1. We propose a novel pathway by which V-ATPase and RILP modulate LE pH and Rab7 activation in concert. This pathway might broadly contribute to pH control during physiologic endosomal maturation or starvation and during pathologic pH neutralization, which occurs via lysosomotropic compounds and in disease states.
Long-Term Oncologic Outcome following Duodenum-Preserving Pancreatic Head Resection for Benign Tumors, Cystic Neoplasms, and Neuroendocrine Tumors: Systematic Review and Meta-analysis
Authors: Beger Hans G. , Mayer Benjamin , Poch Bertram 
Published: April 2024

Abstract
Background
Pancreatoduodenectomy (PD) has a considerable surgical risk for complications and late metabolic morbidity. Parenchyma-sparing resection of benign tumors has the potential to cure patients associated with reduced procedure-related short- and long-term complications.

Materials and Methods
Pubmed, Embase, and Cochrane libraries were searched for studies reporting surgery-related complications following PD and duodenum-preserving total (DPPHRt) or partial (DPPHRp) pancreatic head resection for benign tumors. A total of 38 cohort studies that included data from 1262 patients were analyzed. In total, 729 patients underwent DPPHR and 533 PD.

Results
Concordance between preoperative diagnosis of benign tumors and final histopathology was 90.57% for DPPHR. Cystic and neuroendocrine neoplasms (PNETs) and periampullary tumors (PATs) were observed in 497, 89, and 31 patients, respectively. In total, 34 of 161 (21.1%) patients with intraepithelial papillar mucinous neoplasm exhibited severe dysplasia in the final histopathology. The meta-analysis, when comparing DPPHRt and PD, revealed in-hospital mortality of 1/362 (0.26%) and 8/547 (1.46%) patients, respectively [OR 0.48 (95% CI 0.15–1.58); p = 0.21], and frequency of reoperation of 3.26 % and 6.75%, respectively [OR 0.52 (95% CI 0.28–0.96); p = 0.04]. After a follow-up of 45.8 ± 26.6 months, 14/340 patients with intraductal papillary mucinous neoplasms/mucinous cystic neoplasms (IPMN/MCN, 4.11%) and 2/89 patients with PNET (2.24%) exhibited tumor recurrence. Local recurrence at the resection margin and reoccurrence of tumor growth in the remnant pancreas was comparable after DPPHR or PD [OR 0.94 (95% CI 0.178–5.34); p = 0.96].

Conclusions
DPPHR for benign, premalignant neoplasms provides a cure for patients with low risk of tumor recurrence and significantly fewer early surgery-related complications compared with PD. DPPHR has the potential to replace PD for benign, premalignant cystic and neuroendocrine neoplasms.
Measuring Intangible Capital with Market Prices
Authors: Ewens Michael , Peters Ryan H. , Wang Sean 
Published: April 2024

Accounting standards prohibit internally created knowledge and organizational capital from being disclosed on firm balance sheets. As a result, balance sheets exhibit downward biases that have become exacerbated by increasing levels of intangible investments. To offset these biases, researchers must estimate the value of these off-balance sheet intangibles by capitalizing prior flows of research and development (R&D) and selling, general, and administrative (SG&A). In doing so, a set of capitalization parameters must be assumed (i.e., the R&D depreciation rate and the fraction of SG&A that represents a long-lived asset). We estimate these parameters using market prices from firm exits and use them to capitalize intangibles for a comprehensive panel of firms from 1978 to 2017. We then use a series of validation tests to examine the performance of our intangible capital stocks versus those developed from commonly used parameters. On average, our estimates of intangible capital are 15% smaller than estimates from status quo parameters while exhibiting larger variation across industry. Intangible capital stocks derived from exit price parameters outperform existing measures when explaining market enterprise values and identifying human capital risk. Adjusting book values with exit-based intangible capital stocks markedly attenuates well-documented biases in market-to-book and return on equity ratios while increasing the precision of the high-minus-low asset pricing factor. We conclude that our capitalization parameters create intangible stocks that perform equal to or better than status quo measures in various applications.This paper was accepted by Victoria Ivashina, finance.Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.02058 .
The relationship between screen time and gross motor movement: A cross-sectional study of pre-school aged left-behind children in China
Authors: Yuan Rui , Zhang Jia , Song Pengwei , Qin Long 
Published: April 2024

Objective
To investigate the level of screen time and gross motor movement level and the correlation between them in left-behind children aged 3 to 6 years old in China.

Methods
A randomized whole-group sampling method was used to study 817 left-behind children aged 3–6 years in 15 kindergartens in Xiangcheng city, Henan province. The third version of the Test of Gross Motor Development (TGMD-3) was used to test the children’s gross motor movement level, and the screen time questionnaire was used to test the children’s screen time level. The relationship between the two and the indicators was explored using Pearson’s two-sided correlation and multilevel regression.

Results
The average daily screen time of left-behind children aged 3–6 years old increased with age, and the reporting rate of >2 h/d ranged from 22.43% to 33.73%; gross motor movement of left-behind children aged 3–6 years old increased with age, with significant differences between age (p<0.05). There was a low to moderate negative correlation (r = -0.133 to -0.354, p<0.05) between screen time and gross motor movement in children aged 3–6 years, and multiple regression analysis showed that screen time was predictive of gross motor movement in children (p<0.05), with an explanation rate of 21.4%.

Conclusion
There is a correlation between screen time and gross motor movement development in children aged 3–6 years old left behind, and the gross motor movement ability of children aged 3–6 years old can be developed by reducing screen time and increasing physical activity.
Hypothermia effects on neuronal plasticity post spinal cord injury
Authors: Al-Nashash Hasan , Wong Ka-Leung , ALL Angelo H. 
Published: April 2024

BackgroundSCI is a time-sensitive debilitating neurological condition without treatment options. Although the central nervous system is not programmed for effective endogenous repairs or regeneration, neuroplasticity partially compensates for the dysfunction consequences of SCI.Objective and hypothesisThe purpose of our study is to investigate whether early induction of hypothermia impacts neuronal tissue compensatory mechanisms. Our hypothesis is that although neuroplasticity happens within the neuropathways, both above (forelimbs) and below (hindlimbs) the site of spinal cord injury (SCI), hypothermia further influences the upper limbs’ SSEP signals, even when the SCI is mid-thoracic.Study designA total of 30 male and female adult rats are randomly assigned to four groups (n = 7): sham group, control group undergoing only laminectomy, injury group with normothermia (37°C), and injury group with hypothermia (32°C +/-0.5°C).MethodsThe NYU-Impactor is used to induce mid-thoracic (T8) moderate (12.5 mm) midline contusive injury in rats. Somatosensory evoked potential (SSEP) is an objective and non-invasive procedure to assess the functionality of selective neuropathways. SSEP monitoring of baseline, and on days 4 and 7 post-SCI are performed.ResultsStatistical analysis shows that there are significant differences between the SSEP signal amplitudes recorded when stimulating either forelimb in the group of rats with normothermia compared to the rats treated with 2h of hypothermia on day 4 (left forelimb,p = 0.0417and right forelimb,p = 0.0012) and on day 7 (left forelimb,p = 0.0332and right forelimb,p = 0.0133) post-SCI.ConclusionOur results show that the forelimbs SSEP signals from the two groups of injuries with and without hypothermia have statistically significant differences on days 4 and 7. This indicates the neuroprotective effect of early hypothermia and its influences on stimulating further the neuroplasticity within the upper limbs neural network post-SCI. Timely detection of neuroplasticity and identifying the endogenous and exogenous factors have clinical applications in planning a more effective rehabilitation and functional electrical stimulation (FES) interventions in SCI patients.
Causal associations of particulate matter 2.5 and cardiovascular disease: A two-sample mendelian randomization study
Authors: Cao Ye , Feng Yi , Xia Nan , Zhang Jiancheng 
Published: April 2024

Background
According to epidemiological studies, particulate matter 2.5 (PM2.5) is a significant contributor to cardiovascular disease (CVD). However, making causal inferences is difficult due to the methodological constraints of observational studies. In this study, we used two-sample Mendelian randomization (MR) to examine the causal relationship between PM 2.5 and the risk of CVD.

Methods
Genome-wide association study (GWAS) statistics for PM2.5 and CVD were collected from the FinnGen and UK Biobanks. Mendelian randomization analyses were applied to explore the causal effects of PM2.5 on CVD by selecting single-nucleotide polymorphisms(SNP) as instrumental variables.

Results
The results revealed that a causal effect was observed between PM2.5 and coronary artery disease(IVW: OR 2.06, 95% CI 1.35, 3.14), and hypertension(IVW: OR 1.07, 95% CI 1.03, 1.12). On the contrary, no causal effect was observed between PM2.5 and myocardial infarction(IVW: OR 0.73, 95% CI 0.44, 1.22), heart failure(IVW: OR 1.54, 95% CI 0.96, 2.47), atrial fibrillation(IVW: OR 1.03, 95% CI 0.71, 1.48), and ischemic stroke (IS)(IVW: OR 0.98, 95% CI 0.54, 1.77).

Conclusion
We discovered that there is a causal link between PM2.5 and coronary artery disease and hypertension in the European population, using MR methods. Our discovery may have the significance of public hygiene to improve the understanding of air quality and CVD risk.
County-level factors associated with a mismatch between opioid overdose mortality and availability of opioid treatment facilities
Authors: Rizk John G. , Saini Jannat , Kim Kyungha , Pathan Uzma , Qato Danya M. 
Published: April 2024

Background
Opioid overdose deaths in the United States remain a major public health crisis. Little is known about counties with high rates of opioid overdose mortality but low availability of opioid use disorder (OUD) treatment facilities. We sought to identify characteristics of United States (US) counties with high rates of opioid overdose mortality and low rates of opioid treatment facilities.

Methods
Rates of overdose mortality from 3,130 US counties were compared with availability of opioid treatment facilities that prescribed or allowed medications for OUD (MOUD), from 2018-2019. The outcome variable, “risk-availability mismatch” county, was a binary indicator of a high rate (above national average) of opioid overdose mortality with a low (below national average) rate of opioid treatment facilities. Covariates of interest included county-level sociodemographics and rates of insurance, unemployment, educational attainment, poverty, urbanicity, opioid prescribing, depression, heart disease, Gini index, and Theil index. Multilevel logistic regression, accounting for the clustering of counties within states, was used to determine associations with being a “risk-availability mismatch” county.

Results
Of 3,130 counties, 1,203 (38.4%) had high rates of opioid overdose mortality. A total of 1,098 counties (35.1%) lacked a publicly-available opioid treatment facility in 2019. In the adjusted model, counties with an additional 1% of: white residents (odds ratio, OR, 1.02; 95% CI, 1.01-1.03), unemployment (OR, 1.11; 95% CI, 1.05-1.19), and residents without insurance (OR, 1.04; 95% CI, 1.01-1.08) had increased odds of being a mismatch county. Counties that were metropolitan (versus non-metropolitan) had an increased odds of being a mismatch county (OR, 1.85; 95% CI, 1.45-2.38).

Conclusion
Assessing mismatch between treatment availability and need provides useful information to characterize counties that require greater public health investment. Interventions to reduce overdose mortality are unlikely to be effective if they do not take into account diverse upstream factors, including sociodemographics, disease burden, and geographic context of communities.
Upadacitinib-Induced Hepatitis B Reactivation Leading to Liver Transplant
Authors: Khan Sarosh Ahmed , Zahid Rida , Amir Muhammad 
Published: April 2024

ABSTRACT
Hepatitis B virus (HBV) reactivation can occur with the use of immunosuppressive therapy used to treat autoimmune conditions, such as rheumatoid arthritis. Janus kinase inhibitors, such as upadacitinib, have been approved for the treatment of rheumatoid arthritis. This is the first case report of a patient who used upadacitinib without antiviral prophylaxis against HBV and developed HBV reactivation, leading to fulminant hepatic failure necessitating emergent liver transplantation.
The Atemporal Silence of Aesthetics: Transfeminine Crossplay as Resources for Genderqueer Experimentation in Singapore
Authors: Ang Ming Wei , Ibasco Gabrielle 
Published: April 2024

Abstract
This study investigates how transfeminine crossplay—imagined or enacted crossdressing as feminine characters from anime and manga—offers aesthetic resources for genderqueer experimentation. We situate this investigation in Singapore, an Asian sociopolitical context which privileges social harmony and penalizes vocal dissent. Through interviews with six crossplay fans (some identifying as transgender but not others), we unpack how they harness aesthetics in crossplay to negotiate genderqueer trajectories. Crossplay aesthetics clarified gendered feelings and prospective gendered futures. It created gendered-aesthetic styles, forming new trajectories. But for some, it counterproductively constricted gender experimentation's inventiveness. We argue that aesthetic play constitutes a holding space to silently cultivate gender nonconformity, sidestepping Singapore society's demonization of dissent. By momentarily suspending ties to futural demands of gender identities, crossplay installs a sense of atemporality within gendered aesthetics, encouraging fans to engage gender as aesthetic considerations dissociated from personal and social histories of shame, suffering, and discrimination.
What Differentiates Believers and Non-Believers of Conspiracy Theories? A Structural Analysis of Semantic Networks Regarding the Social Representations of Covid-19 Pandemic
Authors: Katerelos Ioannis , Koletsi Maria 
Published: April 2024

Belief in conspiracy theories is close related with the adoption of behavioral patterns often associated with a direct dispute of scientific research, institutional and governmental practices. The recent Covid-19 pandemic revealed an ecosystem of stories and narratives promoting alternative explanations about a real public threat. The exposure to these narratives and their persuasion towards people’s cognitive structures is a crucial issue to be examined to identify the different strategies implemented, by individuals and groups, in order to address a direct threat to society. In the current exploratory research, we examined whether believing in conspiracy theories about Covid-19 pandemic, is possible to predict semantic networks as cognitive structures. The analysis of the research findings provided different patterns of thought about individual exposure to Covid-19 conspiracy theories, their persuasiveness, and the different levels of compliance to (state-promoted) health measures.
We discuss the importance of future research focusing on the level of acceptance of the role of different social institutions. A systematic analysis of conspiracy theories rationale is possible to address the cognitive bias organized on belief systems that offer a logical problem solving in social uncertainties. A more thorough study on the individual and group perception of the role of institutions, the level of their acceptance or dispute, as well as their direct and indirect impact on the development of socially responsible behaviors, within a shared social reality, could enhance our knowledge towards the development of effective social policies to confront the next public health crisis.