bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytological typing of primary lung cancer: Study of 100 cases with autopsy confirmation
Authors: Dibonito Luigi , Colautti Isabella , Patriarca Silvia , Falconieri Giovanni , Barbazza Renzo , Vielh Philippe 
Published: February 2007

AbstractIn order to assess the accuracy of bronchial aspiration cytology in typing lung cancer, tissue sections from 100 autopsy cases of lung cancer were compared with the cytology features observed in the same patients prior to death. There was 100% accuracy in the cytology of small‐cell carcinoma; 90% in squamous‐cell carcinoma; 70% in adenocarcinoma; and 50% in undifferentiated large‐cell carcinoma. The observed discrepancies probably reject intrinsic tumor properties rather than problems attributable to either the bronchial aspiration method or cytology interpretation, especially in cases involving advanced lung carcinoma. Because the highest accuracy rate was in detecting small‐cell carcinoma, it is recommended that only the distinction between small‐cell and non‐small‐cell forms be made on cytologic grounds and that further categorizations only be rendered in cases with unquestionable cytomorphological features.
Carcinoembryonic antigen in fine‐needle aspirate of liver: A diagnostic adjunct to cytology
Authors: Pinto Marguerite M. , Monteferrante Mark , Kaye Alan D. 
Published: February 2007

AbstractCarcinoembryonic antigen (CEA) was measured in 50 consecutive fine‐needle aspirates of liver to determine whether elevated levels could predict the presence of carcinoma in cytologically negative aspirates. There were 44 malignant and 6 benign lesions. The highest mean CEA values (591–672 ng/ml) were obtained in metastatic adenocarcinoma of the colon, stomach, and pancreas; lower levels (13.5–151 ng/ml) were found in metastatic carcinoma from the breast and lung. Carcinoid, hepatoma, Hodgkin's disease, and benign liver aspirates had low (<5 ng/ml) CEA levels. Cytologic diagnosis of malignancy was 96% sensitive and 100% specific. Using 5 ng as a cutoff for malignancy, the overall sensitivity of CEA for detection of malignancy was 77%; for detection of adenocarcinoma alone, sensitivity was 85%. Specificity was 100%. The CEA content of fine‐needle aspirates generally exceeded serum values by 10–100‐fold. Although CEA content did not enhance the sensitivity of cytologic diagnosis, it may suggest metastatic carcinoma of the GI tract in patients presenting with adenocarcinoma of an unknown primary source.
Clinical prevalence of glomerular hematuria: A nine‐year retrospective study
Authors: Pellet Hélène , Buenerd Annie , Minaire Eliette , Lacavalerie BÉAtrice , Donne Chantal 
Published: February 2007

AbstractThe authors evaluated red blood cell (RBC) morphology by phase contrast microscopy and identified casts and lipidic material in 4,448 urine sediments (US). Microhematuria was discovered on systematic examination in 1,186 apparently healthy patients (group I). Another 4,362 patients (group II) with microscopic or gross hematuria were being treated or evaluated for various renal or extrarenal diseases (renal transplantation excepted). Glomerular hematuria (GH) was observed in 93.1% of group I patients and in 58.0% ofgroup II patients. GH and non‐GH were observed together in 0.6% of cases. The origin of hematuria remained uncertain in 11.6% of cases, In GH, the other cytological findings were as follows: RBC casts were seen in 5.3% of group I and 20.5% of group I; granular and/or cellular casts were seen in 12.8% of group I and 39.6% ofgroup II; and lipidicmaterial was seen in 0.6% of group I and 8.8% of group II. Both groups showed a higher frequency of RBC casts, granular and/or cellular casts, and lipidic material in patients under 20. This method of investigation of urine, which is simple, rapid, inexpensive, and noninvasive, provides useful information for the clinician and avoids unnecessary investigations.
Cytology of treated and minimal Pneumocystis carinii pneumonia and a pitfall of the grocott methenamine silver stain
Authors: Naryshkin Sonya , Daniels Joan , Freno Elaine , Cunningham Larry 
Published: February 2007

AbstractTo clarify the role of foamy alveolar casts (FACs) in the diagnosis of Pneumocystis carinii pneumonia (PCP), we retrospectively reviewed Papanicolaou (Pap)‐ and Grocott methenamine silver (GMS)‐stained slides from 205 bronchial specimens submitted for suspected opportunistic lung infection. FACs containing sporozoites were seen in 86 cases, all with positive GMS. FACs were absent in 119 cases with negative GMS. In patients previously treated for PCP, Pap showed FAC‐like material which lacked sporozoites. GMS demonstrated clumped degenerated Pneumocystis carinii (PC) cysts. In 17 GMS‐positive cases there were no FACs on Pap due to sampling error and low burden of organisms. Morphologic features of macrophages in these cases can suggest the presence of PC. When FACs are lacking, a special stain is required. When GMS is used, the control must contain PC to avoid a false negative GMS. The inconsistent uptake of GMS by PC is a pitfall which is distinct from sampling error and which to our knowledge has not been previously reported.
Fine‐needle aspiration cytology in a case with features of chronic granulomatous disease
Authors: Drut Ricardo 
Published: February 2007

AbstractFine‐needle aspiration cytology (FNAC) of enlarged cervical lymph nodes of a 9‐yr‐old boy complaining of progressive weight loss showed a combination of a necrotizing granulomatous process and pigmented histiocytes. The diagnosis of chronic granulomatous disease (CGD) of childhood was proposed, and it was later confirmed by histology. Although the NBT test was negative, the patient responded well to prolonged bactericidal therapy with trimethoprim‐sulfamethoxazole associated with parenteral nutrition, indicating a rare case of CGD with a negative Nitro‐Blue Tetrazolium (NBT) test. The cytologic findings appear to be unique for this disease.
Papillary carcinoma of the thyroid with anaplastic transformation: Diagnostic pitfalls in fine‐needle aspiration biopsy
Authors: Vinette Danielle S. J. , Macdonald Laurie L. , Yazdi Hossein M. 
Published: February 2007

AbstractA case of coexistent papillary and anaplastic carcinoma of the thyroid is presented. The diagnosis of papillary carcinoma was made by fine‐needle aspiration biopsy (FNAB); however, it did not correspond to the aggressive clinical behavior of the tumor. Subsequent biopsies revealed anaplastic carcinoma in the thyroid and pretracheal tissue. This case most likely represents anaplastic transformation in a pre‐existing papillary carcinoma. The limitations of diagnosing this entity by FNAB as well as some possible solutions are discussed.
Diagnosis of pulmonary blastoma by fine‐needle aspiration biopsy: Cytologic and immunocytochemical findings
Authors: Cosgrove Michele M. , Chandrasoma Parakrama T. , Martin Sue Ellen 
Published: February 2007

AbstractA preoperative diagnosis of pulmonary blastoma was established by fine‐needle aspiration (FNA) cytology in a patient who presented with a pulmonary mass discovered incidentally on chest x‐ray. At the time of computed tomography‐guided FNA, an on‐site preliminary diagnosis of poorly differentiated carcinoma was made after examination of a rapid hematoxylineosin (H a E)‐stained smear. Malignant epithelial and stromal elements could be demonstrated on smears subsequently stained with the H&E, Papanicolaou, and Diff‐Quik methods. The cell block preparation showed a distinctly biphasic malignant tumor with classic morphologic features of pulmonary blastoma. We present the clinical, cytologic, immunocytochemical, and histologic findings of this case and re‐emphasize the valuable contribution of adequate cell block preparations to accurate diagnosis of fine‐needle aspiration material.
Diagnosis of hepatic actinomycosis by fine‐needle aspiration
Authors: Granger John K. , Houn Houn‐Yee David 
Published: February 2007

AbstractA 48‐yr‐old white female with a 20‐yr history of intrauterine device use presented with signs and symptoms suggestive of a disseminated neoplasm with a pelvic primary. A definitive diagnosis of disseminated actinomycosis was made on the basis of computed tomography‐guided fine‐needle aspiration of a liver lesion. Subsequent laparotomy revealed involvement of the endometrium and of the ovaries and uterine tubes bilaterally. This article indicates the usefulness offine‐needle aspiration in the diagnosis of actinomycosis in this case.
Malignant lymphoma in pleural effusions: An immunocytochemical cell surface analysis
Authors: Guzman Josune , Bross Klaus J. , Costabel Ulrich 
Published: February 2007

AbstractNine malignant pleural effusions due to lymphoma were immunocytochemically analyzed with the peroxidase‐antiperoxidase adhesive slide assay for detection of cell surface antigens using a broad panel of monoclonal antibodies. The study population included one case of hairy‐cell leukemia; four cases of B cell non‐Hodgkin's lymphoma (B‐NHL), low malignant grade; two cases of B‐NHL, high malignant grade; one case of Hodgkin's disease; and one case of plasmacytoma. In the cases of B cell lymphoma, high percentages of B cells with monoclonal staining for kappa were found. In hairy‐cell leukemia, the hairy cells reacted with the monoclonal antibodies CD20, CD25, HLA‐DR, CD45, and HLA‐1. In Hodgkin's disease, the Hodgkin cells reacted with CD15, CD20, CD25, CD30, Tü9, and OKT9. The plasmacytoma case showed tumor cells negative for CD20, HLA‐DR, and CD45; partially positive for CD38; positive for HLA‐1; rnonoclonally positive for lambda; and negative for heavy‐chain immunoglobulins. The analysis of nonmalignant lymphocyte subpopulations revealed CD4/CD8 ratios similar to those in effusions of other etiologies. The percentages of natural killer cells (Leu‐7‐positive and CD16‐positive) were small and also similar to percentages in effusions of other etiologies. We conclude that immunocytochemical analysis of pleural effusions allows a clear recognition of B lymphoma cells and also of Hodgkin and hairy cells and that the distribution of nonmalignant lymphocyte subsets is indistinguishable from those found in other malignant and nonmalignant effusions.
Fine‐needle cytology of the breast: A controlled study of aspiration versus nonaspiration
Authors: Ciatto Stefano , Catania Salvatore , Bravetti Patrizia , Bonardi Rita , Cariaggi Paola , Pacifico Emma 
Published: February 2007

AbstractWe report on 534 breast masses examined by fine‐needle aspiration cytology. Two samples were obtained from each mass, one with aspiration and the other without. Aspiration, equivalent to that obtained by a 20‐ml syringe on full aspiration, was obtained by an automatic aspirator. The two sampling modalities did not differ apart from aspiration and were compared in terms of inadequate sampling rates. The inadequacy rate was the same in 166 cancers (6.6%), whereas a signifcant difference was recorded in favor of aspiration (13.6 versus 24.4%) in 368 benign masses. When inadequate results were excluded, the accuracy of the two modalities was almost the same. Sensitivity was 97.4% and 96.7% and specificity was 99.4% and 99.3% for sampling with and without aspiration, respectively. Reducing the rate of inadequate sampling from benign masses seems to be the major advantage of aspiration. Double sampling, independent of the specific techniques, reduced inadequacy rates to very low levels (1.2% for cancers; 5.9% for benign masses) and may be useful as a routine policy.
Fine‐needle aspiration cytology of a renal cell adenocarcinoma with massive intracellular hemosiderin accumulation
Authors: Weaver Michael G. , Al‐Kaisi Nadia , Abdul‐Karim Fadi W. 
Published: February 2007

AbstractThe cytologic findings of a fine‐needle aspiration biopsy of a renal cell adenocarcinoma with massive intracellular hemosiderin accumulation are described. These findings have not been previously illustrated in the cytology literature. These features could also be observed in fine‐needle aspiration biopsies of renal cell adenocarcinoma metastases.
Rhabdomyosarcomatous differentiation in a neuroblastoma: A potential pitfall in the cytologic diagnosis of small round‐cell tumors of childhood
Authors: Layfield Lester J. , Glasgow Ben J. 
Published: February 2007

AbstractRhabdomyoblasts demonstrating immunoreactivity for musclespecific actin, desmin, and myoglobin were identified in smears obtained by aspiration from a large retroperitoneal mass in a 14‐mo‐old girl. Following a tentative diagnosis of a rhabdomyogenous neoplasm, retroperitoneal exploration and adrenalectomy demonstrated a stromal poor neuroblastoma with extensive rhabdomyogenous differentiation. The presence of a subpopulation of rhabdomyoblasts was not diagnostic of rhabdomyosarcoma when obtained by fine‐needle aspiration from a retroperitoneal tumor composed predominantly of primitive small round cells.
An approach to fine‐needle aspiration biopsy diagnosis of hepatic masses
Authors: Bottles Kent , Cohen Michael B. 
Published: February 2007

AbstractAfter reviewing collection techniques and the cytology of normal and reactive hepatocytes, a systematic approach to the evaluation of fine‐needle aspiration biopsy smears of hepatic mass lesions is presented. One of the main problems facing the cytopathologist is the differentiation of cirrhosis from well‐differentiated hepatocel‐Mar carcinoma. Smears from patients with cirrhosis often contain clusters of bile duct epithelial cells and chronic inflammatory cells, while properly sampled hepatocellular carcinoma smears should contain no bile duct epithelial cells and few inflammatory cells. Key criteria which favor the diagnosis of hepatocellular carcinoma over cirrhosis are: increased nuclear to cytoplasmic ratio, trabecular pattern, and atypical naked hepatocytic nuclei. Key criteria which favor the diagnosis of primary hepatocellular carcinoma over metastatic disease include polygonal cells with centrally placed nuclei, cells separated by sinusoidal capillaries, and bile. This systematic approach to the evaluation of hepatic fine‐needle aspiration biopsies must be used with the realization that other uncommon mass lesions of the liver do exist vocal nodular hyperplasia, adenoma, hepatoblastoma, bile duct carcinoma, vascular tumors, mesenchymal tumors, and lymphomas).
Cytomorphologic features of sputum samples from marijuana smokers
Authors: Roby Tina J. , Hubbard Gayle , Swan Gary E. 
Published: February 2007

AbstractHistopathologic evidence in recent literature suggests that habitual, heavy marijuana smoking causes changes in the bronchial airways similar to changes seen in older, habitual cigarette smokers. The cytologic effects of marijuana smoking on the bronchial airways were investigated utilizing a quantitative analysis of sputum. Levels of macrophages (pigmented and nonpigmented), neutrophils, mucus, mucous spirals, and columnar and benign metaplastic cells were measured. The presence or absence of dysplasia, “purse” cells, eosinophils, reactive bronchial lining cells, and benign bronchial hyperplasia was noted. Results were compared across three groups of 25 subjects each: never cigarette or marijuana smokers; marijuana only smokers; and in cigarette only smokers. Results indicate that cytomorphologic changes observed in habitual marijuana smokers are similar to changes observed in tobacco smokers and much different than those observed in nonsmokers. These cytologic findings are similar to those described in other studies from specimens obtained at bronchoscopy.
Cytologic interpretation of fine‐needle aspiration biopsies from clinically occult breast masses
Authors: Howell Lydia P. , Lindfors Karen K. , Russell Liisa A. 
Published: February 2007

AbstractFine‐needle aspiration biopsy (FNAB) was performed on 39 occult breast masses of soft tissue density using standard mammographic guidance. All malignant tumors were diagnosed as either positive or suspicious for carcinoma, and there were no false‐positive or false‐suspicious diagnoses. These excellent results can be attributed to accurate cytologic interpretation based on consideration of problems unique to these lesions and the sampling method, such as scantier cellularity, potentially less confidence in needle placement, and the nature of the occult mass itself. The team approach between pathologist, radiologist, and clinician is emphasized.
Intraocular fine‐needle aspiration biopsy of coronal adenomas
Authors: Glasgow Ben J. 
Published: February 2007

AbstractThe cytologic findings from intraocular biopsy of coronal adenomas of three previously surgically enucleated eyes were studied. Cohesive clusters of nonpigmented epithelial cells were observed. Clusters of epithelial cells were surrounded by characteristic intercellular matrix material. Coronal adenomas have been clinically mistaken for intraocular melanomas. It is important for pathologists to be familiar with the aspiration cytology of the coronal adenoma to avoid unnecessary enucleation or iridocyclectomy.
Cytologic findings in microglandular hyperplasia of the cervix
Authors: Yahr Laura J. , Lee Kenneth R. 
Published: February 2007

AbstractA case of florid microglandular hyperplasia of the uterine cervix that contained cells with severe atypia suggesting malignancy on a Papanicolaou smear is reviewed. Findings from 25 additional smears from patients with microglandular hyperplasia are reported. These sometimes contained glandular cells with varying degrees of atypia, but demonstrated no features specific for microglandular hyperplasia. The distinction between markedly atypical endocervical cells sometimes exfoliated from microglandular hyperplasia and those of adenocarcinoma is discussed.
Diagnosis of salivary gland tumors by fine‐needle aspiration cytology: A review of clinical utility and pitfalls
Authors: Layfield Lester J. , Glasgow Ben J. 
Published: February 2007

AbstractFine‐needle aspiration cytology has become a frequently used technique for the diagnosis of neoplasms of the head and neck. While the method has a high sensitivity and specificity for the diagnosis of salivary gland lesions, important pitfalls for the cytologic diagnosis of these lesions exist. This paper discusses the diagnostic pitfalls and investigates strategies for the evaluation of salivary gland masses.
Aspiration cytology and immunocytochemistry of sacral chordoma with liver metastases: A case report
Authors: Perasole Antonio , Infantolino Domenico , Spigariol Francesco 
Published: February 2007

AbstractWe present the cytologic features and immunocytochemical profile of a case of sacrococcygeal chordoma metastatic to the liver. Cytologic diagnosis was suspected from the aspiration biopsy smears of the primary sacrococcygeal tumor and confirmed by histology. Further aspirates failed to reveal diagnostic physaliferous cells, and only undifferentiated spindle cells were obtained. Chordoma may lack physaliferous cells; in such cases, immunocytochemistry studies can greatly facilitate the diagnosis. This study confirms the utility of irnmunocytochemistry in the differential diagnosis of chordoma and tumors with similar cytologic characteristics.
Granulomatous mastitis secondary to histoplasmosis: Report of a case diagnosed by fine‐needle aspiration biopsy
Authors: Houn Houn‐Yee David , Granger John K. 
Published: February 2007

AbstractA case of unilateral histoplasmal “granulomatous” mastitis diagnosed by fine‐needle aspiration biopsy (FNAB) is presented. The clinical presentation and mammographic findings were strongly suspicious for carcinoma. FNAB cytology showed a picture of necrotizing granuloma secondary to histoplasmosis. The lesion was treated with surgical excision and appropriate antifungal therapy. The differential diagnosis of granulomatous mastitis is discussed.
Fine‐needle aspiration of a solitary pulmonary nodule following treatment of metastatic giant‐cell tumor of bone
Authors: Powers Celeste N. , Bull Joan M. , Raval Pramila , Schmidt Waldemar A. 
Published: February 2007

AbstractGiant cell tumor (GCT) of bone is a local, variably aggressive neoplasm with high local recurrence and occasional pulmonary metastases. Radiographically guided fine‐needle aspiration (FNA) plays a large role in establishing a tissue diagnosis of lung metastases prior to therapeutic intervention. We present a patient with histologically proven pulmonary metastases from a femoral grade II GCT. These lesions were obliterated with combination HT‐CT (hyperthermia and chemotherapy). The patient subsequently developed another pulmonary nodule at a site previously occupied by a GCT metastatic deposit. Radiographically guided FNA revealed that this new lesion was an adenocarcinoma, apparently of pulmonary origin. We suggest that this second neoplasm arose within a scar that developed after HT‐CT ablation of one of the metastases. Additional intriguing features of this case are the effective HT‐CT therapy of GCT metastatic to lung and the extended temporal course (some 16 yr from initial diagnosis to death).
Solitary pleural amyloid nodules occurring as coin lesions diagnosed by fine‐needle aspiration biopsy
Authors: Kaw Yao Tek , Esparza Alfredo R. 
Published: February 2007

AbstractSolitary pleural amyloid nodule is rare and radiologically can mimic neoplastic lesions. This report describes two cases of this entity diagnosed by fine‐needle aspiration biopsy in patients without systemic amyloid deposits. The histologic, ultrastructural, and cytologic features are described.
Vaginocervical cytology in victims of sexual assault
Authors: Costa Michael J. , Tadros Talaat , Tackett Eva , Naib Zuher 
Published: February 2007

AbstractTo investigate the role of vaginocervical smears in alleged victims of rape, we reviewed the findings in 4,220 consecutive rape victims between the years 1982 and 1989. These rape victims showed a slight increase in cellular abnormalities (1.18% vs .93%) when compared to a group of 17,187 routine smears from an indigent population in 1989. While the differences in the spectrum of cellular abnormalities were not statistically significant, the increase in abnormal smears is remarkable because of the younger age distribution and lower risk factors for cervical cancer in this group of rape victims (41% of the victims were never seen at our institution before their evaluation for alleged rape and were most probably of higher socioeconomic status and at lower risk for cervical cancer than the indigent population served at our hospital). This finding may reflect the low incidence of vaginocervical cytology screening among the general population of which rape victims are a random sample. Fifty‐seven percent of the rape victims with cellular abnormalities who were also regular patients at our hospital returned for follow‐up by appropriate repeat smears or biopsies. This was lower than the 95% general follow‐up rate of vaginocervical smear abnormalities among the rest of the population screened at our hospital. We detected spermatozoa in 56% of the smears from victims who were examined within three days of the alleged sexual assault. Cytology adds to the criminal investigation of rape cases as we detected spermatozoa in four of 16 semen‐negative cases from a random sample of 53 cases evaluated by the state crime lab.