bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bristlecone pine tree rings and volcanic eruptions over the last 5000 yr
Authors: Salzer Matthew W. , Hughes Malcolm K. 
Published: September 2006

AbstractMany years of low growth identified in a western USA regional chronology of upper forest border bristlecone pine (Pinus longaeva and Pinus aristata) over the last 5000 yr coincide with known large explosive volcanic eruptions and/or ice core signals of past eruptions. Over the last millennium the agreement between the tree-ring data and volcano/ice-core data is high: years of ring-width minima can be matched with known volcanic eruptions or ice-core volcanic signals in 86% of cases. In previous millennia, while there is substantial concurrence, the agreement decreases with increasing antiquity. Many of the bristlecone pine ring-width minima occurred at the same time as ring-width minima in high latitude trees from northwestern Siberia and/or northern Finland over the past 4000–5000 yr, suggesting climatically-effective events of at least hemispheric scale. In contrast with the ice-core records, the agreement between widely separated tree-ring records does not decrease with increasing antiquity. These data suggest specific intervals when the climate system was or was not particularly sensitive enough to volcanic forcing to affect the trees, and they augment the ice core record in a number of ways: by providing confirmation from an alternative proxy record for volcanic signals, by suggesting alternative dates for eruptions, and by adding to the list of years when volcanic events of global significance were likely, including the mid-2nd-millennium BC eruption of Thera.
Stimulation of self-recovery by similia principle?
Authors: Van Wijk R. , Wiegant F.A.C. 
Published: September 2006

AbstractThis paper describes how the similia principle can be studied best in fundamental research. 2 questions are raised: ‘What is known about the regulatory principles at which homoeopathic treatment is directed?’ and ‘In what kind of conditions can these regulatory principles be studied best?’ The vision of Hahnemann and ideas related to the ‘field concept’ developed in this century are discussed.With respect to the first question, the phenomenon of ‘self-recovery’ takes a central position. The essence of homoeopathy is stimulation of self-recovery by application of the similia principle. By analysing self-recovery on different levels, we conclude that research on the molecular and cell biological level can use low potencies only (containing molecules of the original substance). We consider whether stimulation of disturbed self-repair occurs by application of low doses of the disturbing agent.At the cellular level ‘self-repair’ can be defined as a supplementation of protector proteins, an enhancement of resistance to the disturbing agent and a temporary stimulation of proliferation in order to compensate for cell death. These parameters are clearly defined and can be measured using highly standardised and validated cell biological techniques.
Complaints and diagnoses in homoeopathic practice
Authors: Koster T.G.C. , Jansen G.R.H.J. 
Published: September 2006

AbstractAs part of a 4-phase research project, 58 homoeopathic physicians, all members of VHAN (Dutch Association of Homoeopathic Physicians) registered for 1 week the complaints and diagnoses according to ICPC-code of the first 30 patients given exclusively homoeopathic treatment during that week. A total of 1712 patients, 36% male and 64% female, was registered. Children under 10 and adults from 30–40 years particularly sought homoeopathic treatment.
The rights and wrongs of measles vaccination
Authors: English John M. 
Published: September 2006

AbstractThere is controversy regarding immunization. This paper concentrates on measles although the evidence is more broadly based. Both mortality and morbidity figures strongly suggest that despite a few casualties the campaign has saved many lives and much suffering, even though its goal of eliminating measles has not yet been achieved. Unfortunately the immunizing effect of the vaccine has a shorter duration of action than the disease itself, and this has led to outbreaks of measles amongst older age-groups immunized as babies. Morbidity and mortality are higher when measles is contracted at older ages. A revaccination campaign is under way. Side effects from revaccination are less frequent than with primary vaccination.The incidence of a variety of chronic diseases, some of which are related to the immune system, has risen concurrently with the various immunization programmes. Opponents fear that the two phenomena are connected, and that by proceeding with immunization we are fundamentally damaging the race. While the evidence for such a connection is weak, it cannot entirely be dismissed as it is equally hard to disprove. We should remain alert to the possibility and research it honestly while continuing with the campaign, since abandoning it would undoubtedly result in much more loss of life and permanent disability.
Thinking what we are doing
Authors: Dempsey Thez , Swayne Jeremy 
Published: September 2006

AbstractThis paper presents data from the first and second Faculty Data Collection Surveys of homœopathic prescribing. It describes the use of homœopathy in different clinical settings and by doctors with different levels of prescribing skill, the range of morbidity treated, and the homœopathic medicines and potencies used, and examines the relationships between these different parameters. Although the study cannot be considered definitive, it demonstrates the scope and value of this kind of analysis as a basis for research in homœopathic medicine, and begs a number of questions that require further investigation.
Homœopathic treatment of ovarian cysts
Authors: Gimeno Maria Lluisa Queralt 
Published: September 2006

AbstractForty women suffering from ovarian cysts, diagnosed and measured by ultrasound, were treated with a single homœopathic medicine according to their specific mental, general and local symptoms. The hormonal disorders suffered by these patients lead to several symptoms, some specifically gynaecological, others general or mental, demonstrating how the health deterioration process effects the general state of the sick person. The ultrasound examination was repeated after about nine months. Results were positive.
A study using Sepia 200c given prophylactically postpartum to prevent anoestrus problems in the dairy cow
Authors: Williamson A.V. , Crawford W.J. , Rennie B. , Mackie W.L. 
Published: September 2006

AbstractThe results obtained from a study model using Sepia 200c in a herd of dairy cows led to an extended study. Overall reproductive performance was monitored monthly by a farm action list and the technique of palpation of the ovaries per rectum was used to determine pregnancy and cyclical status. A total of 101 cows were randomly treated with Sepia 200c on day 14 or 21 postpartum.Statistical analysis of the results was based on the differences between the untreated Control and Sepia-treated groups in periparturient disorders and pre- and post-service periods, and between the two Sepia-treated groups.In the pre-service period, a significant difference was found between the sepia-treated groups in the proportion of heifers calved, the number of assisted calvings and pre-service problems compared to Control. A difference of 9.9 total mean days to oestrus post-treatment was found between the Sepia-treated groups.During the post-service period, significant differences were found in the conception rate to first service, the percentage of cows in calf and total culled.A reduction (non significant) was found in the 21-day treatment group compared to control and 14-day treatment in the mean days calving to conception interval and the calving index. However, between the Sepia-treated groups a significant difference was found in total mean days calving to conception interval.The results of this study appear to demonstrate a difference in effect between the Sepia-treated groups and Control group. The study has been extended into a double blind placebo trial to find the effect of using a placebo and assess the use of Sepia given earlier postpartum on herd reproductive performance.
Quality control of homoeopathic medicines
Authors: Davey R. William , McGregor Julia A. , Grange John M. 
Published: September 2006

AbstractThe stability of 55 mother tinctures stored under standard conditions over a twelve month period was estimated in terms of anti-bacterial activity against Pseudomonas aeruginosa, Bacillus cereus and Staphylococcus aureus. There was little change in activity over the period.
A trial of sepia 200
Authors: Williamson A.V. , Crawford W.J. , Rennie B. , Mackie W.L. 
Published: September 2006

AbstractThe effect of Sepia 200c on the reproductive performance of Friesian cross dairy cows was assessed in a controlled trial from September 1989 until August 1990. Overall reproductive performance was monitored monthly and pregnancy diagnosis and cyclical status was determined. The cows were randomly allocated to 4 groups, untreated controls, placebo controls, Sepia-treated 24 to 48 hours postpartum and Sepia-teated day 14 postpartum.The trial was concluded in July 1990 when another treatment was employed to reduce declining herd reproductive status. Statistical analysis of the results was based on differences between the placebo control and the Sepia-treated, 24–48 hours postpartum, the pooled control groups and placebo control with Sepia day 14, and lastly the difference between the 2 Sepia-treated groups.The highest rates of periparturient disease occurred in the Sepia-treated groups, the highest single incidence rate of periparturient disease risk (cysts) found in the cows in the Sepia 24 to 48 hours postpartum group. Sepia day 14 produced the largest percentage of cows seen in first oestrus (45%), the largest number of observed heats (60%) in the cows without periparturient disease risk factors or recurrent traits and the lowest total mean value days to oestrus post-treatment.Sepia day 14 produced the largest percentage that held to first service, the lowest post-treatment period to first service, calving to conception interval, mean number of services and rectal examinations per conception, mean day calving interval and calving index. The results show that the effect of Sepia 200c administered to cows two weeks postpartum increased the numbers of cows observed in first oestrus, held to first service and lowered the calving to conception interval and calving index. The results of the Sepia day 14 postpartum group were also found to be compatible with the same group data reported in the previous study.
Ways to enhance the quality and acceptance of clinical and laboratory studies in homoeopathy
Authors: Melchart D. , Jonas W.B. , Hornung J. , Linde W. 
Published: September 2006

AbstractThree ways to enhance acceptance and publication of clinical trials in homoeopathy and confirmatory laboratory studies on serially agitated dilutions are proposed. First, we recommend the use of methodology and presentation checklists to increase the quality of original papers on research. Second, we recommend to prepare an extensive report available to interested persons if a published report does not include all relevant details. Third, we recommend establishing a preregistration data base for all confirmatory projects of research in homoeopathy.
Importance of the 3c trituration in the manufacture of homœopathic medicines
Authors: Dellmour F. 
Published: September 2006

AbstractBased on the original trituration of gold made in 1818, Hahnemann introduced trituration to the 3c as a general method for use in homœopathic pharmacy from 1835 onwards, thus distancing himself from the use of solutions and mother tinctures. He found that 3c triturated medicines were more effective, with constituents retained to a much higher degree and improved storage qualities.
Three ‘anecdotes’
Authors: Somper Dennis 
Published: September 2006

Abstract16 years from onset, a patient with motor neurone disease lives a normal life. A lady presenting with chronic myeloid leukaemia, the diagnosis confirmed by bone marrow studies, was treated with busulphan for a total of 5 weeks. 14 years later, bone marrow examination was normal and the condition could only be diagnosed from the Philadelphia chromosome.
Research in homœopathy
Authors: Davies Anita E. 
Published: September 2006

SummaryAfter a general introduction and definition of terms, the therapeutic situation is illustrated, followed by a discussion of criteria of success or failure and the factors involved in prescribing the surative remedy—expertise as a doctor, assessment of the symptomatology from the homœopathic point of view, knowledge of the materia medica, methods of prescribing, obstacles to cure, understanding the action of potencies; and throughout suggesting where more individual or group study would increase success, and finally calling for the support of all members of the Faculty.
Homœopathic medicine in the treatment of chronic hypocapnoea
Authors: Davies Anita E. 
Published: September 2006

SummaryHahnemannian concepts of the nature of disease, the function of the “vital force” in contributing to the symptomatology of disease processes, and the need to give the homœopathic remedy to restore health, are discussed. The physiological disturbance caused by habitual hyperventilation is described, and the value of homœopathic medicine in this syndrome is illustrated. The incidence of hypocapnoea in a series of new patients seen by the author is similar to that found in a general medical outpatients. The presenting symptomatology in a random series of hyperventilators seen in the author's private practice is enumerated, and some of the homœopathic remedies used are discussed. No remedy appears specific for hypocapnoea, but Aconite fits the acute symptoms, and Sepia seems to be frequently needed in the treatment of individual patients.
A hypothesis on the nature of homœopathic potencies
Authors: Kumar Aditya , Jussal Ruplal 
Published: September 2006

AbstractIn this paper, it is argued that a homœopathic potency is an arrangement, in a certain order, of electric dipolar molecules of the solvent, induced by the drug during the process of dynamization. (Note that the solvents used in the preparation of homœopathic potencies, viz. water, alcohol and sugar of milk, all have molecules which exhibit electrical dipole moments.) The nature and extent of this arrangement of dipoles depends on the starting drug (Mother Tincture) and the degree of dilution. As a consequence of this hypothesis the dielectric constant and surface tension of the homœopathic potency are expected to be different from those of the solvent. The surface tension of potencies of Natrum muriaticum (NaCl) up to the 30th prepared in 91 per cent. alcohol were measured and were found to vary from one potency to another, thus lending support to the hypothesis.
Treatment of chronic disease
Authors: Boyd H.W. 
Published: September 2006

A summary of the type of chronic conditions treated by homœopathy is given. An outline of chronic case-taking procedure. Prescribing on a specific, a local and a constitutional basis. Are miasms a help? Brief outline of symptomatology of Psora, Sycosis, Syphilis and Tuberculinum.Hierarchy of symptoms—strange and peculiar, mental (with grades of these), general, local.Evaluation of symptoms; directions of cure.Potency choice.
Kent's remarks about Gentry's concordance repertory
Authors: Gypser K.-H. 
Published: September 2006

SummaryTwo statements made by J. T. Kent regarding Gentry's Concordance Repertory—that not over 40 per cent of the materia medica is included and 50 per cent of Gentry's symptoms cannot be found in any materia medica—are scrutinized as to their veracity. The study brought to light that Kent's assertions are untenable and it is supposed that he made them to promote the sale of his own repertory which was by no means a bestseller during his lifetime.
Calcarea sulphurica
Authors: Candegabe Eugenio F. 
Published: September 2006

AbstractThe author presents his personal experiences of this drug based on extensive case material, and points out that the existing pathogenesis shows serious defects. In agreement with Kent, he discusses the possibility of prescribing a drug integrating two pathogeneses, an example being Calcarea arsenicosa, which combines features of Calcarea carbonica and Arsenicum, with brief reference to a number of case histories.It is concluded that the essence of Calcarea sulphurica is a Sulphur subject who also shows the characteristic fears of Calcarea carbonica. On the basis of his experience, the author delineates a characteristic psychosomatic personality for this drug which in his opinion becomes a real polychrest, as it is frequently indicated and rapidly effective.
Two acute cases
Authors: Gypser Klaus-Henning 
Published: September 2006

AbstractTwo acute cases are reported. The first gave verification of a symptom which occurred in the proving of Nux vomica, i.e. ‘pain in forehead extending to root of nose’. The second demonstrated the action of Manganum after Rhus toxicodendron had failed which was seemingly indicated. This was an astonishing result, because the symptoms of Manganum repertorized with the aid of Boenninghausen's Therapeutic Pocket Book could not be clearly identified in the materia medica. Apparently Boenninghausen was right when he said that his Pocket Book ‘opened a way into the wide fields of combinations’.
Thoughts on the management of myalgic encephalomyelitis
Authors: Jenkins Michael 
Published: September 2006

AbstractFor the past few years an increasing number of patients have been presenting with ‘symptoms suggestive of myalgic encephalomyelitis’ (?ME). A very active and vociferous support group has been formed. Controversy about the nature of the illness has raged in the medical profession since the Royal Free disease outbreak in the 1950s.
Multivariate analysis of five homoeopathic medicines in a psychiatric population
Authors: Woodbury Max , Morrison Roger , Shore Jonathan , Rshom Greg Bedayn , Davidson Jonathan 
Published: September 2006

AbstractGrade of Membership Analysis (GoM) is a multivariate statistical technique developed for the purposes of medical classification. It was applied to the drug picture concept of homoeopathy, assessing five common medicines with particular applicability to anxiety. These were Arsenicum album (Ars), Gelsemium (Gels), Argentum nitricum (Arg-n), Lycopodium (Lyc) and Sulphur (Sulph). The patient sample comprised 104 psychiatric outpatients with structured clinical interviewbased primary diagnoses of social phobia, panic disorder, post traumatic stress disorder, obsessive-compulsive disorder, major depression and dysthymia. A homoeopathic screening questionnaire (HSQ) was used to test the integrity of the five drug pictures. Four pure types emerged, providing some evidence to support distinctions between Sulph and Arg-n features, and a pure type with many features of Ars, Arg-n, Lyc and Gels. The fourth pure type contained few of the drug's characteristics. There was some evidence to suggest that psychiatric diagnoses assorted differentially, based on the homoeopathically determined pure types. This study provides qualified support for the drug picture descriptions.
A strict definition of homoeopathy according to Hahnemann
Authors: Adler U.C. , Ambrosio E. , Anelli I.M. , Cappello E. , Guimarães E.C. , De Toledo Cesar A. 
Published: September 2006

AbstractA review of classical and contemporary textbooks showed that although the term homoeopathy is widely known and used, it remains ambiguous and vague. In an attempt towards clarification we present a review of Hahnemann's definition of the term and conclude that it refers to the outcome of interaction between two different vital affections which, however, have very similar effects on living organisms. We found that Hahnemann used examples to demonstrate the homoeopathic phenomena and postulated that homoeopathy could exist without experimental provings in healthy individuals, infinitesimal doses, dynamization and single medicines, all of which are fundamental elements in his methodology. We also discuss the benefits of using one strict conceptual definition of homoeopathy. This can contribute to recognition of the homoeopathic phenomenon in nature and in medical practice.
Effects of Podophyllum peltatum compounds in various preparations and dilutions on human neutrophil functions in vitro
Authors: Chirumbolo S. , Conforti A. , Lussignoli S. , Metelmann H. , Bellavite P. 
Published: September 2006

AbstractHuman blood neutrophil granulocytes (neutrophils) treated with Podophyllum peltatum L.-derived compounds exhibited an enhanced oxidative response to subsequent challenge with bacterial formyl peptides. This priming effect was concerned with superoxide anion (O2 −) release (respiratory burst). The phenomenon was observed with a potentized preparation containing, among other things, podophyllum extract (Podophyllum compositum), with Podophyllum 4x (final concentration of active principle about 0.025 μg/ml), whereas enhancement of O2 − release was not caused by homoeopathic Podophyllum 12x or other components of the complex homoeopathic preparation. Purified podophyllotoxin had the same effect at doses of 0.1–10 μg/ml, whereas doses higher than 100 μg/ml of podophyllotoxin inhibited the respiratory burst, so that pure toxin showed a typical bi-phasic dose-response curve. Similar effects were obtained with purified colchicine (1–1000 μg/ml), a microtubule-disrupting agent. No priming by a Podophyllum-derived compound was observed on neutrophils stimulated with 50 ng/ml phorbol ester. Further, both potentized podophyllum-derived compounds and pure podophyllotoxin-inhibited cellular adhesion to the serum-coated surface of culture microplates. These results show that low potencies of a drug extract have specific stimulating effects on the activation of neutrophil metabolism. The same stimulating effects are also caused by low doses of the active principle of the drug, which is an inhibitor when used at high doses.
The pillar of homoeopathy
Authors: Walach Harald 
Published: September 2006

AbstractThe few controlled trials conducted so far have not shown that the symptoms observedby volunteers in a proving are different from placebo. This finding is discussed from a methodological point of view. Provings conducted so far have not convincingly put the method to experimental trial. Provings designed to improve practical prescribing in homoeopathy, using qualitative methodology, should be distinguished from trials to show that substances in homoeopathic dilutions produce symptoms different from placebo. Both methodologies can be combined and a protocol is suggested.
Effects of high potencies of tumour necrosis factor alpha on H2O2 production in cultured neuroblastoma cells by enhanced luminol-dependent chemiluminescence (ECL)
Authors: Carmine T.C. 
Published: September 2006

AbstractThe effects of homoeopathic high dilutions of cytokine TNFα on H2O2 production of SK-N-SH neuroblastoma cells were studied. H2O2 was measured using a highly sensitive chemiluminescence method (ECL) based on chemical enhancement of luminol oxidation in the presence of peroxidase and H2O2. The dose-effect relationship between TNFα and H2O2 production of SK-N-SH cells was established over the whole range from 200 ng/ml of TNFα to 100x. Interpolation yielded a waveshaped curve (phase length 5–8) which appeared to ‘ride’ on a wave-shaped 10th order regression curve (phase length ∼ 35). The effects of TNFα 100x on H2O2 production were highly significant (p < 0.002). Elevation of H2O2 production compared to controls was repeatedly seen following incubation of SK-N-SH cells in the presence of TNFα 100x. These results suggest that the chemiluminescence method used is suitable to demonstrate and investigate further the influence of homoeopathic high potencies on biological systems.