bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel guidewire‐based stent delivery system: Examination by intravascular ultrasound
Authors: Yamasaki Masao , Ako Junya , Honda Yasuhiro , Hassan Ali , Koo Bon , Abizaid Alexandre , Fitzgerald Peter , Whitbourn Robert 
Published: April 2008

AbstractThis report describes the first‐in‐man experience with a novel 0.014‐in. guidewire‐based, self‐expanding stent delivery system designed for small or tortuous coronary arteries that may be difficult to access with conventional stent‐delivery systems. © 2008 Wiley‐Liss, Inc.
The incidence of clinically significant contrast‐induced nephropathy following non‐emergent coronary angiography
Authors: Weisbord Steven D. , Hartwig Kathryn C. , Sonel Ali F. , Fine Michael J. , Palevsky Paul 
Published: April 2008

AbstractObjectives:The primary aim of this study was to assess the incidence of clinically significant contrast‐induced nephropathy (CIN) among patients undergoing non‐emergent coronary angiography.Background:Although retrospective analyses have emphasized the association of CIN with adverse patient outcomes, the actual incidence of clinically significant CIN following non‐emergent coronary angiography is not clear.Methods:We prospectively identified patients with baseline estimated glomerular filtration rates (eGFR) < 60 ml/min/1.73 m2 undergoing non‐emergent coronary angiography. We measured serum creatinine 48–96 hr following angiography and assessed the incidence of CIN using two definitions, a rise in Scr ≥ 25% and ≥ 0.5 mg/dl. We tracked the need for dialysis, hospitalization related to kidney injury, and 30‐day mortality to examine the association of CIN with these outcomes.Results:We enrolled 181 patients with a median eGFR of 52 ml/min/1.73 m2. Of the 165 patients (91%) with post‐procedure Scr data, the incidence of CIN was 6.1–8.5%. One patient required dialysis (0.55%) and one (0.55%) died within 30 days. Although 38 patients required hospital admission, CIN was not associated with the need for hospitalization. Patients with an increase in Scr ≥ 25% demonstrated a trend toward increased risk for 30‐day mortality (P = 0.09), whereas those with increments in Scr ≥ 0.5 mg/dl had a marginally higher risk for dialysis (P = 0.06) and 30‐day mortality (P = 0.06), although these associations failed to meet the level of statistical significance.Conclusions:Biochemically defined CIN occurs in a small, but notable proportion of patients undergoing non‐emergent coronary angiography. However, clinically significant CIN is very uncommon. © 2008 Wiley‐Liss, Inc.
Late outcomes of drug‐eluting versus bare metal stents in saphenous vein grafts: Propensity score analysis
Authors: Applegate Robert J. , Sacrinty Matthew , Kutcher Michael , Santos Renato , Gandhi Sanjay , Little William 
Published: April 2008

AbstractObjective: To compare late outcomes with the routine use of drug‐eluting stents (DES) compared with bare‐metal stents (BMS) during percutaneous intervention (PCI) of saphenous vein grafts (SVGs). Background: Safety concerns >1 year from stent implantation have been raised about DES used for PCI of SVGs in a small randomized clinical trial. However, there are few studies comparing late outcomes of DES and BMS in routine clinical practice. Methods: Clinical outcomes (nonfatal MI, cardiac mortality) were assessed in 74 consecutive patients who received BMS and 74 consecutive propensity score matched patients that received DES for PCI of SVGs. Clinical follow‐up was censored at 2 years ± 30 days for both stent groups. Results: At 2 years, the hazard ratio for DES compared with BMS for PCI of SVGs for target vessel revascularization was 0.54 (0.21–1.36), nonfatal MI or cardiac death was 0.68 (0.27–1.68), cardiac mortality 1.19 (0.32–4.45), and stent thrombosis 0.49 (0.09–2.66). Similar outcomes were observed stratified by propensity score quintile. Conclusions: The routine clinical use of DES for PCI of SVGs was associated with a safety profile that was similar to that of bare metal stents with a clear trend toward a less frequent need for reinterventions. © 2008 Wiley‐Liss, Inc.
ChemInform Abstract: Ionic Liquid Based Approach to Luminescent LaPO4: Ce, Tb Nanocrystals: Synthesis, Characterization and Application.
Authors: Zharkouskaya Aksana , Feldmann Claus , Trampert Klaus , Heering Wolfgang , Lemmer Uli 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Henry Reaction Catalyzed by a C2‐Symmetric Bis(oxazoline)—Cu(OAc)2×H2O Complex.
Authors: Ginotra Sandeep K. , Singh Vinod K. 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Stable, Convertible Isonitrile as a Formic Acid Carbanion [‐COOH] Equivalent and Its Application in Multicomponent Reactions.
Authors: Kreye Oliver , Westermann Bernhard , Wessjohann Ludger A. 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Formation of 2‐Arylindan‐1,3‐diones and 3‐Alkylphthalides from Methyl o‐[α‐Phenylsulfonyl]toluate.
Authors: Thirumamagal B. T. S. , Narayanasamy Sureshbabu 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Solvent‐Free Mechanochemical Reaction of [60]Fullerene with Phenylhydrazine Hydrochlorides.
Authors: Chen Zhong‐Xiu , Zhu Bo , Wang Guan‐Wu 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Efficient Three‐Component Synthesis of Polysubstituted 2,5‐Dihydro‐1,3‐oxazin‐6‐ones under Mild Conditions.
Authors: Zhang Min , Jiang Huanfeng , Wang Azhong 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of N‐Substituted 9‐[2‐(3,4‐Methylenedioxyphenyl)‐2‐oxoethyl] ‐1,5‐dinitro‐7,8‐benzo‐3‐azabicyclo[3.3.1]non‐7‐en‐6‐ones.
Authors: Yakunina I. E. , Atroshchenko Yu. M. , Shahkheldyan I. V. , Kobrakov K. I. , Troizkiy N. A. , Boikova O. I. 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Xylarinic Acids A and B, New Antifungal Polypropionates from the Fruiting Body of Xylaria polymorpha.
Authors: Jang Yun‐Woo , Lee In‐Kyoung , Kim Young‐Sook , Lee Sangku , Lee Ho‐Jae , Yu Seung Hun , Yun Bong‐Sik 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Understanding Ionic Liquids at the Molecular Level: Facts, Problems, and Controversies
Authors: Weingaertner Hermann 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: P‐Chiral Phosphine Ligands for Transition‐Metal‐Catalyzed Asymmetric Reactions
Authors: Imamoto Tsuneo 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Phosphorylation of neurofilament subunit NF‐M is regulated by activation of NMDA receptors and modulates cytoskeleton stability and neuronal shape
Authors: Fiumelli H. , Riederer I. M. , Martin J.‐L , Riederer B. M. 
Published: April 2008

AbstractThe cytoskeleton is essential for the structural organization of neurons and is influenced during development by excitatory stimuli such as activation of glutamate receptors. In particular, NMDA receptors are known to modulate the function of several cytoskeletal proteins and to influence cell morphology, but the underlying molecular and cellular mechanisms remain unclear. Here, we characterized the neurofilament subunit NF‐M in cultures of developing mouse cortical neurons chronically exposed to NMDA receptor antagonists. Western blots analysis showed that treatment of cortical neurons with MK801 or AP5 shifted the size of NF‐M towards higher molecular weights. Dephosphorylation assay revealed that this increased size of NF‐M observed after chronic exposure to NMDA receptor antagonists was due to phosphorylation. Neurons treated with cyclosporin, an inhibitor of the Ca2+‐dependent phosphatase calcineurin, also showed increased levels of phosphorylated NF‐M. Moreover, analysis of neurofilament stability revealed that the phosphorylation of NF‐M, resulting from NMDA receptor inhibition, enhanced the solubility of NF‐M. Finally, cortical neurons cultured in the presence of the NMDA receptor antagonists MK801 and AP5 grew longer neurites. Together, these data indicate that a blockade of NMDA receptors during development of cortical neurons increases the phosphorylation state and the solubility of NF‐M, thereby favoring neurite outgrowth. This also underlines that dynamics of the neurofilament and microtubule cytoskeleton is fundamental for growth processes. Cell Motil. Cytoskeleton 2008. © 2008 Wiley‐Liss, Inc.
Dynamic rearrangement of F‐actin organization triggered by host‐specific plant signal is linked to morphogenesis of Aphanomyces cochlioides zoospores
Authors: Islam Md. Tofazzal 
Published: April 2008

AbstractCochliophilin A (5‐hydroxy‐6,7‐methylenedioxyflavone), a root releasing host‐specific plant signal triggers chemotaxis and subsequent morphological changes in pathogenic Aphanomyces cochlioides zoospores before host penetration. The present study illustrates time‐course changing patterns of cytoskeletal filamentous actin (F‐actin) organization in the zoospores of A. cochlioides during rapid morphological changes (encystment and germination) after exposure to cochliophilin A. Confocal laser scanning microscopic analysis revealed that F‐actin microfilaments remained concentrated at ventral groove and diffusely distributed in peripheral cytoplasm of the zoospore. These microfilaments dramatically rearranged and changed into granular F‐actin plaques interconnected with fine arrays during encystment. A large patch of actin arrays accumulated at one pole of the cystospores just before germination. Then the actin plaques moved to the emerging germ tube where a distinct cap of microfilaments was seen at the tip of the emerging hypha. Zoospores treated with an inhibitor of F‐actin polymerization, latrunculin B or motility halting and regeneration inducing compound nicotinamide, displayed different patterns of F‐actin in both zoospores and cystospores than those obtained by the induction of cochliophilin A. Collectively, these results indicate that the host‐specific plant signal cochliophilin A triggers a dynamic polymerization/depolymerization of F‐actin in pathogenic A. cochlioides zoospores during early events of plant‐peronosporomycete interactions. Cell Motil. Cytoskeleton 2008. © 2008 Wiley‐Liss, Inc.
Forced overexpression of either of the two common human Foxp3 isoforms can induce regulatory T cells from CD4+CD25– cells
Authors: Aarts‐Riemens Tineke , Emmelot Maarten E. , Verdonck Leo F. , Mutis Tuna 
Published: April 2008

AbstractThe forkhead/winged helix transcription factor (Foxp3) is expressed as two different isoforms in humans: the full‐length isoform (Foxp3FL) and an alternative‐splicing product lacking the exon 2 (Foxp3ΔE2). We here studied the cellular distribution of Foxp3 isoforms by quantitative PCR and evaluated the functional outcome of retroviral transduction of Foxp3FL and Foxp3ΔE2 genes into CD4+CD25– cells. In PBMC, both isoforms were preferentially expressed in CD4+CD25hi cells. In single‐cell‐sorted and expanded Treg, both Foxp3 isoforms were expressed simultaneously but without a fixed ratio. Forced expression of Foxp3FL or Foxp3ΔE2 genes in CD4+CD25– T cells induced bona fide Treg that not only displayed Treg phenotype but also were anergic and mediated significant suppressive activity against CD3‐activated CD4+CD25– cells. GFP– nontransduced cells or cells transduced with an empty vector showed no Treg phenotype, anergy or suppressive activities. In conclusion, our results reveal that both Foxp3 isoforms possess similar capacities to induce Treg; however, unnaturally high expression levels are required to convey Treg functions to CD4+CD25– cells. As both Foxp3 isoforms appear to be expressed in an independent fashion, studies aiming at quantification of Treg in peripheral blood or in tissue samples can benefit from determination of total Foxp3 levels rather than one of the isoforms.
Epstein‐Barr virus‐induced gene 3 negatively regulates IL‐17, IL‐22 and RORγt
Authors: Yang Jianfei , Yang Min , Htut Tin Min , Ouyang Xinshou , Hanidu Adedayo , Li Xiang , Sellati Rosemarie , Jiang Huiping , Zhang Shu , Li Hongxing , Zhao Jie , Ting Adrian T. , Mayer Lloyd , Unkeless Jay C. , Labadia Mark E. , Hodge Martin , Li Jun , Xiong Huabao 
Published: April 2008

AbstractEpstein‐Barr virus‐induced gene 3 (EBI3) associates with p28 to form IL‐27 and with IL‐12p35 to form IL‐35. IL‐27Rα–/– mice studies indicate that IL‐27 negatively regulates Th17 cell differentiation. However, no EBI3, p28 or p35‐deficiency studies that directly address the role of EBI3, p28 or p35 on Th17 cells have been done. Here, we demonstrate that spleen cells derived from EBI3–/– mice produce significantly higher levels of IL‐17 as well as IL‐22 upon stimulation with OVA. In vitro derived EBI3–/– Th17 cells also produced significantly higher levels of IL‐17 and IL‐22 than WT cells. The frequency of IL‐17‐producing cells was also elevated when EBI3–/– cells were cultured under Th17 conditions. In addition, spleen cells from EBI3–/– mice immunized with Listeria monocytogenes produced significantly elevated levels of IL‐17 and IL‐22. Furthermore, the Th17 transcription factor RORγt was significantly enhanced in EBI3–/– cells. Finally, EBI3–/– mice exhibited a reduced bacterial load following an acute challenge with L. monocytogenes or a re‐challenge of previously immunized mice, suggesting that EBI3 negatively regulates both innate and adaptive immunity. Taken together, these data provide direct evidence that EBI3 negatively regulates the expression of IL‐17, IL‐22 and RORγt as well as protective immunity against L. monocytogenes.
Luminescent Gold(I) and Copper(I) Phosphane Complexes Containing the 4‐Nitrophenylthiolate Ligand: Observation of π→π* Charge‐Transfer Emission
Authors: Li Cheng‐Hui , Kui Steven Chi Fai , Sham Iona Hiu Tung , Chui Stephen Sin‐Yin , Che Chi‐Ming 
Published: April 2008

AbstractGold(I) and copper(I) phosphane complexes containing the 4‐nitrophenylthiolate ligand, namely [(PCy3)Au(SC6H4NO2‐4)] (1) (PCy3 = tricyclohexylphosphane), [Au2(μ‐dcpm)(SC6H4NO2‐4)2] (2) [dcpm = bis(dicyclohexylphosphanyl)methane], [Au2(μ‐dppm)(SC6H4NO2‐4)2] (3) [dppm = bis(diphenylphosphanyl)methane], and [(μ2‐SC6H4NO2‐4)2(μ3‐SC6H4NO2‐4)2(CuPPh3)4] (4), were prepared and characterized by X‐ray crystal analysis. All of these complexes show an intense absorption band with λmax at 396–409 nm attributed to the intraligand (IL) π(S)→π*(C6H4NO2‐4) charge‐transfer transition. The assignment is supported by the results of DFT and TDDFT calculations on the model complexes [PH3Au(SC6H4NO2‐4)] and [(μ2‐SC6H4NO2‐4)2(μ3‐SC6H4NO2‐4)2(CuPH3)4]. The emissions of solid samples and glassy solutions (methanol/ethanol, 1:4, v/v) of 1–4 at 77 K are assigned to the [π(S)→π*(C6H4NO2‐4)] charge‐transfer excited state. Metallophilic interactions are not observed in both solid state and solutions of complexes 1–3. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Electron‐Sponge Behavior, Reactivity and Electronic Structures of Cobalt‐Centered Cubic Co9Te6(CO)8 Clusters (Eur. J. Inorg. Chem. 12/2008)
Authors: Bencharif Mustapha , Cador Olivier , Cattey Hélène , Ebner Alexander , Halet Jean‐François , Kahlal Samia , Meier Walter , Mugnier Yves , Saillard Jean‐Yves , Schwarz Patrick , Trodi Fatima Zohra , Wachter Joachim , Zabel Manfred 
Published: April 2008

AbstractThe cover picture shows an organometallic electron sponge and an elephant‐ear sponge in the background (photo by F. and J. Burek, National Marine Sanctuaries). The electronic flexibility of the cobalt‐centered cubic [Co9Te6(CO)8]n cluster ([3]n) in the central circle is expressed by differently charged states (n = 1+ to 5–). Starting from the upper left corner of our graphic in a clockwise direction, neutral [Co9Te6(CO)4(PPh3)4], structurally diverse networks of [Ph3PNPPh3][3] and [Ph3PNPPh3]2[3] salts and the core of the [Co9Te3{ν5‐Cp′2Nb(CO)Te}3(CO)8] cluster as a pseudo‐protonated representative of the [3]3– anion are shown. Details of the structural, electrochemical and theoretical properties of these compounds are described in the article by J. Wachter et al. on page 1959 ff.
Neutral Group‐IV Metal Catalysts for the Intramolecular Hydroamination of Alkenes
Authors: Müller Carsten , Saak Wolfgang , Doye Sven 
Published: April 2008

AbstractA detailed comparison of the group‐IV metal catalysts Ti(NMe2)4, Ind2TiMe2, Ind2ZrMe2 and Ind2HfMe2 in the intramolecular hydroamination of amino alkenes is presented. Among these catalysts, the benchmark catalyst Ti(NMe2)4 is the most active in the formation of pyrrolidines. A comparison between Ind2TiMe2, Ind2ZrMe2 and Ind2HfMe2 suggests that in the synthesis of pyrrolidines, Zr complexes show the highest catalytic activity of the group‐IV metal catalysts. Although Ind2TiMe2‐ and the Ind2ZrMe2‐catalyzed formation of a pyrrolidine is first‐order in the concentration of the substrate, the corresponding Ti(NMe2)4‐catalyzed cyclization is second‐order in the concentration of the substrate. The results obtained for the formation of piperidines catalyzed by Ti(NMe2)4, Ind2TiMe2, Ind2ZrMe2 and Ind2HfMe2 suggest that for these reactions, Ti catalysts show increased catalytic activity compared with the corresponding Zr catalysts. Unfortunately, the formation of aminocyclopentane side‐products by C–H activation processes is a severe drawback of the Ti catalysts. The corresponding side‐products are not formed in Ind2ZrMe2‐ and Ind2HfMe2‐catalyzed reactions. However, the former catalyst gives better yields of the desired piperidine products. In contrast to the results obtained for the synthesis of pyrrolidines, the formation of a piperidine is zero‐order in the concentration of the substrate for the indenyl catalysts Ind2TiMe2 and Ind2ZrMe2, and first‐order for the homoleptic catalyst Ti(NMe2)4. Interestingly, Ind2TiMe2 is able to catalyze a slow hydroamination of an N‐methylated amino alkene, whereas the homoleptic complex Ti(NMe2)4 as well as Ind2ZrMe2 and Ind2HfMe2 do not catalyze the same reaction. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Redox‐Controlled Fluorescence Modulation in a BODIPY‐Quinone Dyad
Authors: Benniston Andrew C. , Copley Graeme , Elliott Kristopher J. , Harrington Ross W. , Clegg William 
Published: April 2008

AbstractThe synthesis and properties of two closely related boron dipyrromethene (BODIPY) derived dyads, incorporating redox‐active quinone units appended at the meso position, are described. For one dyad, the quinone unit is attached directly to the BODIPY core, whereas a phenylene spacer separates the two units in the second compound. Each of the quinone units is readily converted, by both chemical and electrochemical means, to the corresponding hydroquinone derivative. The strong fluorescence normally associated with the BODIPY unit is efficiently quenched in both dyads in their quinone forms. This is attributed to deactivation of the first excited singlet state by a way of an intramolecular electron‐transfer process. By comparison, moderately intense fluorescence is observed for the hydroquinone derivative containing the phenylene spacer, but not for the analogous directlycoupled dyad. The potential sensing capabilities of the phenylene‐spaced BODIPY quinone and hydroquinone dyads, towards reducing and oxidising species such as ascorbate and peroxide, were tested in a biomembrane mimic. A reversible modulation in fluorescence could be readily detected by eye under standard UV‐light excitation. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Ultraselective and Sensitive Determination of Cr(VI) in the Presence of a High Excess of Cr(III) in Natural Waters with a Complicated Matrix
Authors: Grabarczyk Malgorzata 
Published: April 2008

AbstractIn the present work, the catalytic adsorptive stripping voltammetric procedure for trace determination of Cr(VI) in the presence of a high excess of Cr(III) in natural waters with a complicated matrix has been developed. The influence from potentially interfering substances such as organic matter was successfully eliminated by exploiting adsorptive properties of polymeric resin. The detection limit estimated from 3 times the standard deviation for a low Cr(VI) concentration in the simultaneous presence of a 2×103 fold excess of Cr(III), 50 mg L−1 surfactants, 50 mg L−1 humic substances and the accumulation time of 30 s was about 5.3×10−10 mol L−1.
The Application of the Risk Concept to Debris Flow Hazards
Authors: Fuchs Sven , Kaitna Roland , Scheidl Christian , Hübl Johannes 
Published: April 2008

AbstractDebris flows present a serious hazard in alpine regions, where natural environment meets the space of human interest such as settlements and infrastructure. In the past various measures have been developed to protect human life and property. However, a complete protection from damage is not possible, also due to limited financial resources of public fund providers. Therefore, the concept of risk management was adopted from technical sciences as an alternative and sustainable protection strategy, and was increasingly implemented in Alpine countries within the last decades. This paper provides an introduction to the state of the art in risk analysis for debris flow hazards, including an overview of different but complementary methods for debris flow risk analysis at different scales.