bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the Spanish translation Sheffield Profile for Assessment and Referral for Care (SPARC-Sp) at the Hospital Universitario San Jose of Popayan, Colombia
Authors: Mendieta Cindy V. , Calvache Jose A. , Rondón Martín A. , Rincón-Rodríguez Carlos Javier , Ahmedzai Sam H. , de Vries Esther 
Published: March 2024

AbstractObjectivesWe determined the validity and reliability of the Spanish translation Sheffield Profile for Assessment and Referral for Care (SPARC-Sp) questionnaire to identify the palliative care (PC) needs of patients with chronic noncommunicable diseases (NCDs) in Colombia.MethodsWe developed a cross-sectional observational study of scale assessment in adults with the aim of determining the validity and reliability of the SPARC-Sp questionnaire to identify the PC needs of patients with NCDs receiving outpatient or inpatient care at the Hospital Universitario San Jose of Popayan – ESE, Colombia, from 2021 to 2022.ResultsWe applied a questionnaire consisting of demographic, clinical data, and SPARC-Sp to 507 participants. The constructed model explained 75% of the variance with an adequate fit according to the root mean square residual (0.03), the comparative fit index (0.98), and acceptable reliability (McDonald’s total omega 0.4–0.9). Opportunities for improvement are the reformulation and inclusion of particular words to improve the representativeness and clarity of the domains of communication and information, religious, and spiritual issues.Significance of resultsThis research represents the first validation of SPARC in Spanish. SPARC-Sp is an instrument that allows initiating a conversation of the patient’s main needs through a systematic assessment of the patients’ main needs. Its psychometric validation demonstrated good fit and acceptable reliability.
Evolution of Antarctic Sea Ice Ahead of the Record Low Annual Maximum Extent in September 2023
Authors: Jena Babula , Kshitija S. , Bajish C. C. , Turner John , Holmes Caroline , Wilkinson Jeremy , Mohan Rahul , Thamban M. 
Published: March 2024

AbstractThe 2023 Antarctic sea ice extent (SIE) maximum on 7 September was the lowest annual maximum in the satellite era (16.98 × 106 km2), with the largest contributions to the anomaly coming from the Ross (37.7%, −0.57 × 106 km2) and Weddell (32.9%, −0.49 × 106 km2) Seas. The SIE was low due to anomalously warm (>0.3°C) upper‐ocean temperatures combined with anomalously strong northerly winds impeding the ice advance during the fall and winter. Northerly winds of >12 ms−1 in the Weddell Sea occurred because of negative pressure anomalies over the Antarctic Peninsula, while those in the Ross Sea were associated with extreme blocking episodes off the Ross Ice Shelf. The Ross Sea experienced an unprecedented SIE decrease of −1.08 × 103 km2 d−1 from 1 June till the annual maximum. The passage of quasi‐stationary and explosive polar cyclones contributed to periods of southward ice‐edge shift in both sectors.
Vertical Interaction Between NBC Rings and Its Implications for South Atlantic Water Export
Authors: Napolitano Dante C. , Carton Xavier , Gula Jonathan 
Published: March 2024

AbstractNorthwestward‐propagating North Brazil Current (NBC) Rings are often destroyed upon reaching the Caribbean islands, carrying South Atlantic waters into the North Atlantic gyre and connecting the two branches of the Atlantic Meridional Overturning Circulation. Recent observations of NBC rings reported surface and subsurface cores separated by strong stratification. As independent structures, the subsurface eddies often appeared below—even if not aligned with—the surface rings. Motivated by these findings, this paper investigates the occurrence and consequences of vertical coupling between surface and subsurface NBC rings by applying a simplified theoretical model to a realistic numerical simulation. Eddy tracking in this complex simulation reveals around 1,600 instantaneous observations where eddies overlap. At each observation, we assess the eddies' vertical interaction with a 21/2‐layer quasi‐geostrophic framework. This interaction boils down to either coupling between the layers or a vertical splitting of the system, depending on eddy strength versus background shear. The effects of coupling include long‐lived eddies that can travel longer distances. These effects are particularly important for the lower layer, where differences between coupled and non‐coupled eddies are striking: about 40% of eddies with coupling travel 500 km, with ∼10% carrying South Atlantic Water up to the Caribbean sea. Without coupling, eddies propagate less than 150 km. During coupling, lower‐layer eddies could be driven by their surface counterparts to move offshore and bypass a topographic choke point, thus leaving the NBC retroflection region. Although still speculative, this idea explains the link between coupling and the increase in both lifetime and distance traveled for these eddies.
Extracellular vesicle-mediated transfer of miRNA-1 from primary tumors represses the growth of distant metastases
Authors: Kim Chae-Yi , Lee Kang-Hoon , Son Keun Hong , Shin Tae-Jin , Cho Je-Yoel 
Published: March 2024

AbstractMetastases originate from primary tumors and reach distant organs. Growing evidence suggests that metastases are under the control of primary tumors even outside the primary site; however, the mechanisms by which primary tumors remotely control metastases remain unclear. Here, we discovered a molecular mechanism by which primary tumors suppress metastatic growth. Interestingly, we found that extracellular vesicles (EVs) derived from the primary tumor can inhibit the growth of metastases both in vitro and in vivo. miR-1 was particularly enriched in primary tumor-derived EVs (pTDEs) and was found to be responsible for the suppression of metastatic growth. Mechanistically, intracellular reactive oxygen species (ROS) production and DNA damage were induced, which led to cell cycle arrest. Collectively, our data demonstrate that primary tumors restrict the growth of distant metastases via miR-1 in pTDEs and that miR-1 could potentially be used as an antimetastatic agent.
Radiotherapy in younger patients with advanced aggressive B-cell lymphoma—long-term results from the phase 3 R-MegaCHOEP trial
Authors: Oertel Michael , Ziepert Marita , Frontzek Fabian , Nacke Nina , Altmann Bettina , Nickelsen Maike , Glass Bertram , Poeschel Viola , Ruebe Christian , Lenz Georg , Schmitz Norbert , Eich Hans Theodor 
Published: March 2024

AbstractThe role of consolidative radiotherapy (RT) for patients with aggressive B-cell lymphoma has not been fully elucidated. The R-MegaCHOEP trial investigated the use of high-dose chemotherapy and rituximab with subsequent autologous stem cell transplantations compared to conventional immunochemotherapy (R-CHOEP) for high-risk patients up to 60 years. The study protocol included RT for patients with bulky (maximum diameter ≥7.5 cm) or extranodal disease. Two-hundred sixty-one patients were analyzed, 120 of whom underwent RT. The most frequently irradiated regions were mediastinum (n = 50) and paraaortic (n = 27). Median RT dose was 36 Gray in median fractions of 1.8 Gray. Acute toxicities were mostly mild to moderate, with only 24 and 8 grade 3 and 4 toxicities reported during RT. Patients with bulky disease who received RT showed significantly better 10-year EFS, PFS and OS (EFS: 64% vs. 35%; p < 0.001; PFS 68% vs. 47%; p = 0.003; OS: 72% vs. 59%; p = 0.011). There was no significant increase in secondary malignancies with the use of RT. RT administered for consolidation of bulky disease after immunochemotherapy improved the prognosis of young high-risk patients with aggressive B-cell lymphoma and should be considered part of first-line therapy. The trial was registered with ClinicalTrials.gov, number NCT00129090.
Antimicrobial efficacy of Odontopaste in endodontics: a systematic review
Authors: Kendell-Wall Rachael , Nguyen Jennifer-Thuy , Salleras Fauve , Kamboj Amandeep Singh , Diwen Tan Serene Aimee , Manish Trivedi Vaidehi , de Mello-Neto João Martins , Rodrigues Amaral Rodrigo 
Published: March 2024

Abstract
Aim
To evaluate the efficacy of Odontopaste in reducing the microbial load in endodontics compared to other intracanal medicaments.

Materials and methods
The literature was electronically searched on PubMed, Google Scholar, Scopus, Ovid Medline and Web of Science. In-vitro, ex-vivo and in-vivo studies that evaluated the antimicrobial efficacy of Odontopaste were included. The risk of bias was assessed using the Quality Assessment Tool for In Vitro Studies.

Results
A total of four in-vitro studies were included in the systematic review. One study showed that Odontopaste had significantly more microbial cell growth on roots in all dentine depths compared to other medicaments or test agents. Another study found that Odontopaste significantly decreased colony-forming units compared to propolis and chlorhexidine. Further results showed that Odontopaste did not significantly decrease microbial numbers when used in isolation. Additionally, combining Odontopaste and calcium hydroxide did not enhance the effectiveness of calcium hydroxide. The studies had a medium to high risk of bias.

Conclusion
There is insufficient high-quality evidence to assess the antimicrobial efficacy of Odontopaste compared to other intracanal medicaments. Further research is required to determine Odontopaste’s efficacy as an antimicrobial medicament in endodontics.
Plasticity of circadian and circatidal rhythms in activity and transcriptomic dynamics in a freshwater snail
Authors: Yokomizo Takumi , Takahashi Yuma 
Published: March 2024

AbstractOrganisms have diverse biological clocks synchronised with environmental cycles depending on their habitats. Anticipation of tidal changes has driven the evolution of circatidal rhythms in some marine species. In the freshwater snail, Semisulcospira reiniana, individuals in nontidal areas exhibit circadian rhythms, whereas those in tidal areas exhibit both circadian and circatidal rhythms. We investigated whether the circatidal rhythms are genetically determined or induced by environmental cycles. The exposure to a simulated tidal cycle did not change the intensity of circatidal rhythm in individuals in the nontidal population. However, snails in the tidal population showed different activity rhythms depending on the presence or absence of the exposure. Transcriptome analysis revealed that genes with circatidal oscillation increased due to entrainment to the tidal cycle in both populations and dominant rhythmicity was consistent with the environmental cycle. These results suggest plasticity in the endogenous rhythm in the gene expression in both populations. Note that circatidal oscillating genes were more abundant in the tidal population than in the nontidal population, suggesting that a greater number of genes are associated with circatidal clocks in the tidal population compared to the nontidal population. This increase of circatidal clock–controlled genes in the tidal population could be caused by genetic changes in the biological clock or the experience of tidal cycle in the early life stage. Our findings suggest that the plasticity of biological rhythms may have contributed to the adaptation to the tidal environment in S. reiniana.
Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles
Authors: Faulkes Chris G. , Eykyn Thomas R. , Miljkovic Jan Lj. , Gilbert James D. , Charles Rebecca L. , Prag Hiran A. , Patel Nikayla , Hart Daniel W. , Murphy Michael P. , Bennett Nigel C. , Aksentijevic Dunja 
Published: March 2024

AbstractThe naked mole-rat Heterocephalus glaber is a eusocial mammal exhibiting extreme longevity (37-year lifespan), extraordinary resistance to hypoxia and absence of cardiovascular disease. To identify the mechanisms behind these exceptional traits, metabolomics and RNAseq of cardiac tissue from naked mole-rats was compared to other African mole-rat genera (Cape, Cape dune, Common, Natal, Mahali, Highveld and Damaraland mole-rats) and evolutionarily divergent mammals (Hottentot golden mole and C57/BL6 mouse). We identify metabolic and genetic adaptations unique to naked mole-rats including elevated glycogen, thus enabling glycolytic ATP generation during cardiac ischemia. Elevated normoxic expression of HIF-1α is observed while downstream hypoxia responsive-genes are down-regulated, suggesting adaptation to low oxygen environments. Naked mole-rat hearts show reduced succinate levels during ischemia compared to C57/BL6 mouse and negligible tissue damage following ischemia-reperfusion injury. These evolutionary traits reflect adaptation to a unique hypoxic and eusocial lifestyle that collectively may contribute to their longevity and health span.
Expected and unexpected effects after systemic inhibition of Hippo transcriptional output in cancer
Authors: Baroja Isabel , Kyriakidis Nikolaos C. , Halder Georg , Moya Iván M. 
Published: March 2024

AbstractHyperactivation of YAP/TAZ, the Hippo pathway downstream effectors, is common in human cancer. The requirement of YAP/TAZ for cancer cell survival in preclinical models, prompted the development of pharmacological inhibitors that suppress their transcriptional activity. However, systemic YAP/TAZ inhibition may sometimes have unpredictable patient outcomes, with limited or even adverse effects because YAP/TAZ action is not simply tumor promoting but also tumor suppressive in some cell types. Here, we review the role of the Hippo pathway in distinct tumor cell populations, discuss the impact of inhibiting Hippo output on tumor growth, and examine current developments in YAP/TAZ inhibitors.
Development and validation of an interpretable model integrating multimodal information for improving ovarian cancer diagnosis
Authors: Xiang Huiling , Xiao Yongjie , Li Fang , Li Chunyan , Liu Lixian , Deng Tingting , Yan Cuiju , Zhou Fengtao , Wang Xi , Ou Jinjing , Lin Qingguang , Hong Ruixia , Huang Lishu , Luo Luyang , Lin Huangjing , Lin Xi , Chen Hao 
Published: March 2024

AbstractOvarian cancer, a group of heterogeneous diseases, presents with extensive characteristics with the highest mortality among gynecological malignancies. Accurate and early diagnosis of ovarian cancer is of great significance. Here, we present OvcaFinder, an interpretable model constructed from ultrasound images-based deep learning (DL) predictions, Ovarian–Adnexal Reporting and Data System scores from radiologists, and routine clinical variables. OvcaFinder outperforms the clinical model and the DL model with area under the curves (AUCs) of 0.978, and 0.947 in the internal and external test datasets, respectively. OvcaFinder assistance led to improved AUCs of radiologists and inter-reader agreement. The average AUCs were improved from 0.927 to 0.977 and from 0.904 to 0.941, and the false positive rates were decreased by 13.4% and 8.3% in the internal and external test datasets, respectively. This highlights the potential of OvcaFinder to improve the diagnostic accuracy, and consistency of radiologists in identifying ovarian cancer.
Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples
Authors: Vladimirov Nikita , Voigt Fabian F. , Naert Thomas , Araujo Gabriela R. , Cai Ruiyao , Reuss Anna Maria , Zhao Shan , Schmid Patricia , Hildebrand Sven , Schaettin Martina , Groos Dominik , Mateos José María , Bethge Philipp , Yamamoto Taiyo , Aerne Valentino , Roebroeck Alard , Ertürk Ali , Aguzzi Adriano , Ziegler Urs , Stoeckli Esther , Baudis Laura , Lienkamp Soeren S. , Helmchen Fritjof 
Published: March 2024

AbstractIn 2015, we launched the mesoSPIM initiative, an open-source project for making light-sheet microscopy of large cleared tissues more accessible. Meanwhile, the demand for imaging larger samples at higher speed and resolution has increased, requiring major improvements in the capabilities of such microscopes. Here, we introduce the next-generation mesoSPIM (“Benchtop”) with a significantly increased field of view, improved resolution, higher throughput, more affordable cost, and simpler assembly compared to the original version. We develop an optical method for testing detection objectives that enables us to select objectives optimal for light-sheet imaging with large-sensor cameras. The improved mesoSPIM achieves high spatial resolution (1.5 µm laterally, 3.3 µm axially) across the entire field of view, magnification up to 20×, and supports sample sizes ranging from sub-mm up to several centimeters while being compatible with multiple clearing techniques. The microscope serves a broad range of applications in neuroscience, developmental biology, pathology, and even physics.
Decreasing exciton dissociation rates for reduced voltage losses in organic solar cells
Authors: Wu Hongbo , Lu Hao , Li Yungui , Zhou Xin , Zhou Guanqing , Pan Hailin , Wu Hanyu , Feng Xunda , Liu Feng , Vandewal Koen , Tress Wolfgang , Ma Zaifei , Bo Zhishan , Tang Zheng 
Published: March 2024

AbstractEnhancing the device electroluminescence quantum efficiency (EQEEL) is a critical factor in mitigating non-radiative voltage losses (VNR) and further improving the performance of organic solar cells (OSCs). While the common understanding attributes EQEEL in OSCs to the dynamics of charge transfer (CT) states, persistent efforts to manipulate these decay dynamics have yielded limited results, with the EQEEL of high-efficiency OSCs typically remaining below 10−2%. This value is considerably lower than that observed in high efficiency inorganic photovoltaic devices. Here, we report that EQEEL is also influenced by the dissociation rate constant of singlet states (kDS). Importantly, in contrast to the traditional belief that advocates maximizing kDS for superior photovoltaic quantum efficiency (EQEPV), a controlled reduction in kDS is shown to enhance EQEEL without compromising EQEPV. Consequently, a promising experimental approach to address the VNR challenge is proposed, resulting in a significant improvement in the performance of OSCs.
Anomalous anti-Kasha excited-state luminescence from symmetry-breaking heterogeneous carbon bisnanohoops
Authors: Zhang Xinyu , Chen Cheng , Zhang Wen , Yin Nan , Yuan Bing , Zhuang Guilin , Wang Xiao-Ye , Du Pingwu 
Published: March 2024

AbstractIt is a long-standing scientific controversy to achieve anti-Kasha-type multiple emissions by tuning the structures at a molecular level. Although it is known that some conjugated structures have excitation-dependent multiple emissions, no all-benzenoid molecules have yet been reported, the emissions of which originate from different excited states. Herein, we report the design of two symmetry-breaking heterogeneous carbon bisnanohoops that in solution become multiple fluorescent emitters with unusual anti-Kasha characteristics. This phenomenon can be spectroscopically and theoretically explained and will find applications in a wide range of sensing and imaging technologies.
High-performance ferroelectric field-effect transistors with ultra-thin indium tin oxide channels for flexible and transparent electronics
Authors: Li Qingxuan , Wang Siwei , Li Zhenhai , Hu Xuemeng , Liu Yongkai , Yu Jiajie , Yang Yafen , Wang Tianyu , Meng Jialin , Sun Qingqing , Zhang David Wei , Chen Lin 
Published: March 2024

AbstractWith the development of wearable devices and hafnium-based ferroelectrics (FE), there is an increasing demand for high-performance flexible ferroelectric memories. However, developing ferroelectric memories that simultaneously exhibit good flexibility and significant performance has proven challenging. Here, we developed a high-performance flexible field-effect transistor (FeFET) device with a thermal budget of less than 400 °C by integrating Zr-doped HfO2 (HZO) and ultra-thin indium tin oxide (ITO). The proposed FeFET has a large memory window (MW) of 2.78 V, a high current on/off ratio (ION/IOFF) of over 108, and high endurance up to 2×107 cycles. In addition, the FeFETs under different bending conditions exhibit excellent neuromorphic properties. The device exhibits excellent bending reliability over 5×105 pulse cycles at a bending radius of 5 mm. The efficient integration of hafnium-based ferroelectric materials with promising ultrathin channel materials (ITO) offers unique opportunities to enable high-performance back-end-of-line (BEOL) compatible wearable FeFETs for edge intelligence applications.
Significant enhancement of proton conductivity in solid acid at the monolayer limit
Authors: Zhang Zhangcai , Liang Lixin , Feng Jianze , Hou Guangjin , Ren Wencai 
Published: March 2024

AbstractProton transport in nanofluidic channels is not only fundamentally important but also essential for energy applications. Although various strategies have been developed to improve the concentration of active protons in the nanochannels, it remains challenging to achieve a proton conductivity higher than that of Nafion, the benchmark for proton conductors. Here, taking H3Sb3P2O14 and HSbP2O8 as examples, we show that the interactions between protons and the layer frameworks in layered solid acid HnMnZ2O3n+5 are substantially reduced at the monolayer limit, which significantly increases the number of active protons and consequently improves the proton conductivities by ∼8 ‒ 66 times depending on the humidity. The membranes assembled by monolayer H3Sb3P2O14 and HSbP2O8 nanosheets exhibit in-plane proton conductivities of ~ 1.02 and 1.18 S cm−1 at 100% relative humidity and 90 °C, respectively, which are over 5 times higher than the conductivity of Nafion. This work provides a general strategy for facilitating proton transport, which will have broad implications in advancing both nanofluidic research and device applications from energy storage and conversion to neuromorphic computing.
Observation of naturally canalized phonon polaritons in LiV2O5 thin layers
Authors: F. Tresguerres-Mata Ana I. , Lanza Christian , Taboada-Gutiérrez Javier , Matson Joseph. R. , Álvarez-Pérez Gonzalo , Isobe Masahiko , Tarazaga Martín-Luengo Aitana , Duan Jiahua , Partel Stefan , Vélez María , Martín-Sánchez Javier , Nikitin Alexey Y. , Caldwell Joshua D. , Alonso-González Pablo 
Published: March 2024

AbstractPolariton canalization is characterized by intrinsic collimation of energy flow along a single crystalline axis. This optical phenomenon has been experimentally demonstrated at the nanoscale by stacking and twisting van der Waals (vdW) layers of α-MoO3, by combining α-MoO3 and graphene, or by fabricating an h-BN metasurface. However, these material platforms have significant drawbacks, such as complex fabrication and high optical losses in the case of metasurfaces. Ideally, it would be possible to canalize polaritons “naturally” in a single pristine layer. Here, we theoretically predict and experimentally demonstrate naturally canalized phonon polaritons (PhPs) in a single thin layer of the vdW crystal LiV2O5. In addition to canalization, PhPs in LiV2O5 exhibit strong field confinement ($${{{{{{\boldsymbol{\lambda }}}}}}}_{{{{{{\bf{p}}}}}}} \sim \frac{{{{{{{\boldsymbol{\lambda }}}}}}}_{{{{{{\bf{0}}}}}}}}{{{{{{\bf{27}}}}}}}$$

λ

p

~

λ

0

27

), slow group velocity (0.0015c), and ultra-low losses (lifetimes of 2 ps). Our findings are promising for the implementation of low-loss optical nanodevices where strongly directional light propagation is needed, such as waveguides or optical routers.