bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum C-reactive protein concentrations in dogs with multicentric lymphoma undergoing chemotherapy
Authors: Merlo Alexandre , Rezende Bárbara Cristina Gagliano , Franchini Maria Luisa , Simões Denise Maria Nunes , Lucas Sílvia Regina Ricci 
Published: February 2007

Abstract
Objective—To determine whether serum C-reactive protein (CRP) concentration is high in dogs with multicentric lymphoma, whether CRP concentration changes in response to chemotherapy, and whether CRP concentration can be used as a marker for relapse in dogs with multicentric lymphoma.
Design—Cohort study.
Animals—20 dogs with multicentric lymphoma and 8 healthy control dogs undergoing chemotherapy with cyclophosphamide, vincristine, and prednisone (CVP) or with vincristine, cyclophosphamide, methotrexate, and L-asparaginase (VCMA) and 20 other healthy dogs.
Procedures—Serum CRP concentration was measured weekly during the first month of chemotherapy and then at 3-week intervals until relapse in dogs with multicentric lymphoma, weekly for 16 weeks in healthy dogs undergoing chemotherapy, and once in the healthy dogs not undergoing chemotherapy.
Results—For both groups of dogs with lymphoma, mean serum CRP concentration during week 1 (prior to treatment) was significantly higher than mean concentrations following induction of chemotherapy and at the time of relapse.Mean serum CRP concentration in the healthy dogs undergoing chemotherapy was not significantly different at any time from mean concentration for the healthy dogs not undergoing chemotherapy.No significant dif ferences were observed between dogs treated with CVP and dogs treated with VCMA.
Conclusions and Clinical Relevance—Results suggest that serum CRP concentration is high in dogs with multicentric lymphoma but that serum CRP concentration is not a useful marker for relapse and that chemotherapy itself does not affect serum CRP concentration.
Use of vascular access ports with intrathoracic drains for treatment of pleural effusion in three dogs
Authors: Cahalane Alane K. , Flanders James A. , Steffey Michele A. , Rassnick Kenneth M. 
Published: February 2007

Abstract
Case Description—3 dogs (9 to 12 years old) were evaluated because of recurrent pleural effusion that was refractory to treatment of the underlying cause.
Clinical Findings—Dogs were evaluated because of cough, dyspnea, tachypnea, or lethargy or a combination of these clinical signs. Radiography, ultrasonography, or thoracocentesis were used to confirm the presence of pleural fluid in each dog. A neoplastic cause of pleural effusion was confirmed in 2 dogs. In 1 dog, fasciitis of the mediastinum and the left parietal pleura was diagnosed, with no evidence of neoplasia.
Treatment and Outcome—Each dog was anesthestized, and thoracotomy was performed with manual perforation of the mediastinum. Permanent, subcutaneously placed vascular access ports were attached to intrathoracic, Jackson-Pratt drain tubing for repeated drainage of pleural fluid. Drains were used successfully in the 3 dogs for periods of 6 weeks, 11 weeks, and > 3 years.
Clinical Relevance—Findings suggest that subcutaneous vascular access ports attached to intrathoracic drain tubing may be an effective way to remove recurrent pleural effusion in dogs.
Systemic infection with Geomyces organisms in a dog with lytic bone lesions
Authors: Erne Jay B. , Walker Mark C. , Strik Nicole , Alleman A. Rick 
Published: February 2007

Abstract
Case Description—A 5-year-old neutered male mixed-breed dog was evaluated by a veterinarian because of a 4-week history of progressive lethargy and poor appetite; the dog was then examined at a referral hospital.
Clinical Findings—Hyperglobulinemia was identified via serum biochemical analyses performed before and after arrival at the hospital. Lysis of sternebrae 1 and 2 and sternal lymphadenopathy were detected radiographically. Fine-needle aspirates were collected from the affected sternebrae and lymph node for cytologic examination; findings were consistent with pyogranulomatous inflammation associated with fungal infiltrates. Geomyces organisms were identified via microbial culture of sternebral aspirates.
Treatment and Outcome—Treatment consisted of oral administration of itraconazole. After 6 months, remodeling of the affected sternebrae and resolution of sternebral lysis were evident radiographically. Geomyces organisms and pyogranulomatous infiltrates persisted despite clinical improvement. Treatment with itraconazole was continued for an additional 3 months.
Clinical Relevance—Infection with Geomyces organisms is typically localized to the skin and nail beds. In the dog of this report, systemic dissemination of Geomyces organisms resulted in lysis of the first 2 sternebrae. Cytologic examination of fine-needle aspirates and microbial culture of samples of the affected sternebrae were important diagnostic tests for successful identification of the organism. Despite 6 months of itraconazole administration and evidence of clinical improvement, fungal organisms persisted in the dog's affected sternebrae. Practitioners should include Geomyces infection among the differential diagnoses for suspected systemic mycosis and should perform cytologic examination and microbial culture of affected tissue throughout treatment of affected dogs.
Use of successive dynamic videoendoscopic evaluations to identify progression of recurrent laryngeal neuropathy in three horses
Authors: Davidson Elizabeth J. , Martin Benson B. , Parente Eric J. 
Published: February 2007

Abstract
Case Description—3 racehorses were evaluated because of poor performance or abnormal noise originating from the upper portion of the respiratory tract.
Clinical Findings—During maximal exercise, initial dynamic videoendoscopy of the upper respiratory tract revealed complete arytenoid cartilage abduction in 2 horses and incomplete but adequate abduction of the left arytenoid cartilage in 1 horse. Subsequent exercising endoscopic evaluation revealed severe dynamic collapse of the left arytenoid cartilage and vocal fold in all 3 horses.
Treatment and Outcome—2 horses were treated with prosthetic left laryngoplasty and raced successfully. One horse was retired from racing.
Clinical Relevance—Idiopathic laryngeal hemiplegia can be a progressive disease. Successive dynamic videoendoscopic upper airway evaluations were used to confirm progression of left laryngeal hemiplegia in these 3 horses. Videoendoscopy of the upper respiratory tract during exercise should be considered as part of the clinical evaluation of horses with signs of upper respiratory tract dysfunction.
Aggression, conflict resolution, popularity, and attitude to school in Russian adolescents
Authors: Butovskaya Marina L. , Timentschik Vera M. , Burkova Valentina N. 
Published: February 2007

AbstractThe objective of the present study was to examine the effects of aggression and conflict‐managing skills on popularity and attitude to school in Russian adolescents. Three types of aggression (physical, verbal, and indirect), constructive conflict resolution, third‐party intervention, withdrawal, and victimization were examined using the Peer‐Estimated Conflict Behavior (PECOBE) inventory [Bjorkquist and Osterman, 1998]. Also, all respondents rated peer and self‐popularity with same‐sex classmates and personal attitude to school. The sample consisted of 212 Russian adolescents (101 boys, 111 girls) aged between 11 and 15 years. The findings attest to significant sex differences in aggression and conflict resolution patterns. Boys scored higher on physical and verbal aggression, and girls on indirect aggression. Girls were socially more skillful than boys in the use of peaceful means of conflict resolution (they scored higher on constructive conflict resolution and third‐party intervention). The attributional discrepancy index (ADI) scores were negative for all three types of aggression in both sexes. Verbal aggression is apparently more condemned in boys than in girls. ADI scores were positive for constructive conflict resolution and third‐party intervention in both genders, being higher in boys. In girls, verbal aggression was positively correlated with popularity. In both sexes, popularity showed a positive correlation with constructive conflict resolution and third‐party intervention, and a negative correlation with withdrawal and victimization. Boys who liked school were popular with same‐sex peers and scored higher on constructive conflict resolution. Girls who liked school were less aggressive according to peer rating. They also rated higher on conflict resolution and third‐party intervention. Physical aggression was related to age. The results are discussed in a cross‐cultural perspective. Aggress. Behav. 33:170–183, 2007. © 2007 Wiley‐Liss, Inc.
Highly crystalline activated layered double hydroxides as solid acid‐base catalysts
Authors: Lei Xiaodong , Zhang Fazhi , Yang Lan , Guo Xiaoxiao , Tian Yuanyuan , Fu Shanshan , Li Feng , Evans David G. , Duan Xue 
Published: February 2007

AbstractActivated layered double hydroxides (LDHs) with high crystallinity, obtained by calcination/rehydration of LDH precursors synthesized by urea decomposition, have higher catalytic activity in acetone self‐condensation and Knoevenagel reactions than less crystalline materials obtained from LDH precursors synthesized by titration co‐precipitation. The activated LDHs possess both basic and acidic sites. High resolution transmission electron microscopy (HRTEM) confirms that the highly crystalline activated LDHs retain the lattice structure of the LDH precursors with lattice parameters a = b = 0.31 ± 0.01 nm and α = 60 ± 2°. An acid‐base catalytic mechanism has been proposed to interpret the catalytic behavior based on the fact that acid‐base hydroxyl group pairs on the activated LDH surface have a separation of 0.31 nm. It is proposed that the active sites are mainly located on the ordered array of hydroxyl sites on the basal surfaces rather than on the edges, as has been previously suggested. © 2007 American Institute of Chemical Engineers AIChE J, 2007
Craniofacial anomalies, humero‐radial synostosis, rhizomelic limb shortness: Previously unrecognized autosomal recessive syndrome
Authors: Al‐Hassnan Zuhair N. , Teebi Ahmad S. 
Published: February 2007

AbstractHumero‐radial synostosis (HRS) is a rare skeletal anomaly that might be seen in some craniosynostosis syndromes, notably Antley–Bixler syndrome, and in other disorders in association with skeletal anomalies. Here we report on two daughters of first cousin Saudi parents with syndromic HRS. Both patients had distinctive craniofacial features including cranium bifidum occultum, hypertelorism, epicanthus inversus, capillary hemangiomata, and malformed ears. Musculoskeletal examination revealed rhizomelic shortness with normal hands and feet. Skeletal survey showed bilateral HRS with no evidence of craniosynostosis. The craniofacial manifestations in these two patients do not match any of the syndromes known to be associated with HRS. We consider that the constellation is unique and apparently represents a previously unrecognized syndrome. © 2007 Wiley‐Liss, Inc.
First trimester ultrasonography in screening and detection of fetal anomalies
Authors: Sonek Jiri 
Published: February 2007

AbstractAn obstetrical ultrasound examination provides invaluable information regarding the fetus. Until the mid‐1980s, ultrasound in the first trimester was limited to localization of the pregnancy, establishing viability, and accurate dating. With the advent of high‐resolution ultrasound and transvaginal scanning, a significant amount of information about the fetus can be gained and provided to the patient at a very early stage in gestation. This article provides an overview of the role of first trimester (11–13 + 6 weeks' gestation) ultrasound in screening and diagnosis of fetal anomalies. The first trimester is an ideal time for screening for aneuploidy, primarily due to the advantages that nuchal translucency (NT) measurement provides. NT measurement is also useful in establishing the risk of congenital cardiac disorders and a number of genetic and non‐genetic syndromes. Significant NT thickening is associated with an increase in perinatal morbidity and mortality. Potential mechanisms resulting in increased NT are discussed. A number of new ultrasound markers for fetal aneuploidy have been investigated over the past several years, some of which appear to improve the screening efficacy of early ultrasonography. The role of these is reviewed. A number of fetal anomalies can now be consistently diagnosed in the first trimester. Their appearance at this early gestational age is discussed as well. It is clear that, data obtained by first trimester ultrasound are useful in counseling expectant parents and in planning the appropriate follow‐up. © 2007 Wiley‐Liss, Inc.
The inhibitive effect of poly(p‐toluidine) on corrosion of iron in 1M HCL solutions
Authors: Manivel P. , Venkatachari G. 
Published: February 2007

AbstractIn recent years, polymer amines have been recognized as an excellent corrosion inhibitors for iron in acid solutions. In this work, the inhibitive effect of p‐toluidine and poly(p‐toluidine) on corrosion of iron in 1M HCl has been studied by the electrochemical methods such as impedance, linear polarization, Tafel polarization techniques. The effectiveness of poly(p‐toluidine) was found to be high in comparison with that of monomer. The results showed that p‐toluidine and poly(p‐toluidine) suppressed both cathodic and anodic processes of iron dissolution in 1M HCl. The inhibition efficiency of both p‐toluidine and poly(p‐toluidine) were found to increase with the inhibitor concentrations. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2007
Eosinophilic fasciitis in a rhesus macaque
Authors: Anderson Scott T. , Klein Edwin C. 
Published: February 2007

AbstractEosinophilic fasciitis (EF) is an inflammatory disorder in the category of scleroderma‐like connective tissue diseases. There are no animal models for spontaneously occurring EF. We present the case of a rhesus macaque (Macaca mulatta) with clinical, laboratory, and histologic features of EF.
Precision of the larsen and the sharp methods of assessing radiologic change in patients with rheumatoid arthritis
Authors: Cuchacovich Miguel , Couret Marie , Peray Pascals , Gatica HÉCtor , Sany Jacques 
Published: February 2007

AbstractObjective. To compare the sensitivity of Sharp's and Larsen's radiographic scoring methods for detecting change in rheumatoid arthritis (RA) over time.Methods. Radiographs of the hands and wrists were taken at the beginning and at the end of a 2‐year followup period, in 42 patients with active RA. Films were scored blindly using both scoring methods. Patients were under treatment with methotrexate (intramuscular injections).Results. Radiographic evidence of progression or amelioration was detected in 25 patients by Larsen's method and in 35 patients by Sharp's method. The relative sensitivity to change over time was greater for Sharp's method (0.01 < P < 0.025).Conclusion. Sharp's radiographic scoring method seems to be more sensitive to change over time than is Larsen's method. The clinical importance of the change needs to be definitively established.
Antibodies in raheumatoid synovial fluids bind to a restricted series of protein antigens in rheumatoid synovial tissue
Authors: Lafyatis Robert , Flipo Rene M. , Duquesnoy Bernard , Capron Andre 
Published: February 2007

AbstractObjective. By searching the synovial fluid of patients with rheumatoid arthritis (RA) for antibodies that react to protein antigens in synovial tissue, we sought to identify putative antigens present in RA synovial tissue that might drive the pathologic immune response believed to be responsible for the joint inflammation.Methods. Synovial tissue was homogenized in sodium dodecyl sulfate polyacrylamide gel buffer, electrophoresed, and analyzed by immunoblotting.Results. Antibodies from synovial fluids of patients with RA bound to several proteins in rheumatoid synovial tissues, including a series of low (27.5‐, 29‐, and 30‐kd), middle (43‐ and 53‐kd), and high (140‐, 164‐, and 182‐kd) molecular weight proteins. Most of these antigens were also detected in normal synovial tissue, and the high molecular weight proteins were also present in normal dermal, muscle, and liver tissues. The low and middle molecular weight proteins were detected in some, but not all, of the other normal tissues and in Jurkat cell lysates. Antibodies to the low and high series of proteins were present in all rheumatoid synovial fluids tested, but were generally absent from synovial fluids from patients with other arthritic diseases.Conclusion. These results show that antibodies in synovial fluids consistently react to several proteins in RA and normal synovial tissues. These antigens are possibly the same antigens provoking the T cell response in RA; therefore, understanding the mechanism of the immune response against these proteins will likely lead to important insight into the etiology of RA.
The effect of interleukin‐1 on cytokine gene expression in cultured human articular chondrocytes analyzed by messenger rna phenotyping
Authors: Seid Janet M. , Rahman Shamim , Graveley Robert , Bunning Rowena A. D. , Nordmann Rene , Wishart William , Graham Russell R. 
Published: February 2007

AbstractObjective. To investigate the pattern of cytokine gene expression in human articular chondrocytes in culture in response to interleukin‐1β (IL‐1β). The effect of serum and variations in culture conditions was also studied.Methods. Messenger RNA was extracted from cells, reverse‐transcribed to complementary DNA, and amplified by the polymerase chain reaction (PCR), using specific oligonucleotide primers. The PCR products were validated by restriction analysis with specific enzymes and by Southern blot analysis.Results. In cultured articular chondrocytes, IL‐1β, IL‐1α, granulocyte colony‐stimulating factor (CSF), and granulocyte‐macrophage CSF cytokine genes were expressed only after induction by IL‐1β. However, IL‐6, IL‐8, and macrophage CSF genes were expressed constitutively. The expression of IL‐1β was dose and time dependent.Conclusion. Using PCR, it was possible to demonstrate gene expression for several cytokines in human articular chondrocytes in culture. It was evident that some cytokine genes were expressed constitutively and some were inducible by IL‐1β.
The measurement of collagenase, tissue inhibitor of metalloproteinases (timp), and collagenase—timp complex in synovial fluids from patients with osteoarthritis and rheumatoid arthritis
Authors: Clark I. M. , Powell L. K. , Ramsey S. , Hazleman B. L. , Cawston T. E. 
Published: February 2007

AbstractObjective. To compare the levels of collagenase, tissue inhibitor of metalloproteinases (TIMP), and collagenase—TIMP complex in synovial fluid (SF) from patients with rheumatoid arthritis (RA) and patients with osteoarthritis (OA). This study aims to clarify existing data from previously used enzyme or inhibitor activity assays performed following separation by gel filtration, by using a 1‐step enzyme‐linked immunosorbent assay (ELISA) for each component.Methods. Total collagenase, free TIMP, and collagenase—TIMP complex were measured using a newly developed, specific double‐antibody sandwich ELISA.Results. Levels of both collagenase and TIMP were significantly higher in RA patients (collagenase 1,560 ± 150 ng/ml [mean ± SEM], TIMP 1,610 ± 130 ng/ml; n = 80) than OA patients (collagenase 420 ± 90 ng/ml, TIMP 1,050 ± 60 ng/ml; n = 80), with the difference being especially striking for collagenase. Sixteen RA fluids had detectable levels of collagenase—TIMP complex, compared with only 3 OA fluids.Conclusion. The level of total collagenase in SF is greater in RA than OA, while levels of free TIMP show more overlap between the 2 diseases; this may simply reflect the increased inflammation seen in RA, or it may reflect a different disease mechanism.
Inclusion body myositis and renal cell carcinoma. report of two cases and review of the literature
Authors: Ytterberg Steven R. , Roelofs Robert I. , Mahowald Maren L. 
Published: February 2007

AbstractObjective. To describe the clinical course of 2 patients with concurrent inclusion body myositis and renal cell carcinoma and review published reports of inclusion body myositis associated with malignancy.Methods. Prospective followup of 2 patients. Review of published case reports and series of patients with inclusion body myositis.Results. Our 2 patients with inclusion body myositis and renal cell carcinoma had no improvement of strength following nephrectomy. Seven previously reported cases of inclusion body myositis and malignancy were identified and are discussed.Conclusion. Findings in our 2 patients suggest that there is no etiopathologic relationship between inclusion body myositis and malignancy.
Cancer in systemic sclerosis
Authors: Abu‐Shakra Mahmoud , Guillemin Francis , Lee Peter 
Published: February 2007

AbstractObjective. To determine whether the frequency of cancer is increased among patients with systemic sclerosis (SSc).Methods. A retrospective chart review of 248 patients who were followed up prospectively was conducted.Results. Cancers developed in 18 patients (7.3%) during 2,001 patient‐years at risk. The most frequent types were cancers of the lung (7 patients) and breast (5 patients). Older age at diagnosis of SSc was a significant risk factor for cancer. Lung cancer was associated with the presence of pulmonary fibrosis. The age‐standardized incidence rate for all cancers (7.9/1,000) was 2.1 times the overall rate in the Ontario population (P > 0.0001).Conclusion. The frequency of cancer is increased in patients with SSc.
Suppression of human cartilage proteoglycan synthesis by rheumatoid synovial fluid mononuclear cells activated with mycobacterial 60‐kd heat‐shock protein
Authors: Wilbrink B. , Holewijn M. , Bijlsma J. W. J. , Van Roy J. L. A. M. , Den Otter W. , Van Eden W. 
Published: February 2007

AbstractObjective. To examine whether T cell reactivity toward heat‐shock proteins (HSP) contributes to cartilage destruction in rheumatoid arthritis (RA).Methods. An in vitro system was used, in which human cartilage explants were cocultured with hsp60‐activated synovial fluid mononuclear cells (SFMC) from patients with RA, and proteoglycan (PG) synthesis was measured.Results. The hsp60‐activated SFMC suppressed cartilage PG synthesis. This effect was dependent on the production of interleukin‐1 (IL‐1) and tumor necrosis factor α (TNFα).Conclusion. Mycobacterial 60‐kd heat‐shock protein can activate rheumatoid SFMC to suppress human cartilage PG synthesis. This suppression is mediated by IL‐1 and TNFα.
Evaluation of the european spondylarthropathy study group preliminary classification criteria in alaskan eskimo populations
Authors: Boyer Georgiana S. , Templin David W. , Goring Wendell P. 
Published: February 2007

AbstractObjective. To evaluate the preliminary classification criteria proposed by the European Spondylarthropathy Study Group (ESSG) in Alaskan Eskimo populations.Methods. We examined, interviewed, and reviewed the records of 104 Eskimo patients with spondylarthropathy and 75 with other rheumatic disorders, and evaluated them according to the proposed criteria.Results. We found an overall sensitivity of 88.5% and a specificity of 89.3%, which is similar to the reported values in European populations.Conclusion. The ESSG criteria performed well in a population very different from that in which they were developed, and deserve further evaluation as a much‐needed and useful epidemiologic tool.