bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH PEMBELAJARAN KOOPERATIF TIPE STAD (STUDENT TEAM ACHIEVEMENT DIVISION) TERHADAP HASIL BELAJAR LITERASI NUMERASI SISWA
Authors: Khoiroh Siti Zumarotul , Andreastya Vian Hanes 
Published: February 2025

Pembelajaran Kooperatif STAD merupakan pembelajaran secara berkelompok bertujuan untuk meningkatkan prestasi belajar peserta didik, dengan pembelajaran matematika, dengan literasi numerasi program K.13 dalam kurikulum merdeka. Yang bertujuan untuk mendeskripsikan pengaruh Pembelajaran Kooperatif STAD Terhadap Hasil Belajar Literasi Numerasi, di Madrasah Ibtidaiyah Islamiyah Ngoro. Peneliti ini menggunakan pendekatan kuantitatif dengan desain true eskperimental design dengan tipe posttest-only control design. Dengan teknik purposive sampling. Pengumpulan data dilakukan dengan menggunakan teknik interview, dokumentasi, observasi, dan instrumen sebagai data penelitian. Analisis yang dilakukan oleh peneliti dengan; uji validitas, reabilitas, uji hipotesis dan uji mann whetney. Dari hasil uji analisis reabilitas diketahui conbach’s alpha 0,864 >0,06 dari uji validitas. Dinyatakan bahwa butir tes hasil belajar literasi numerasi terhadap metode pembelajaran STAD telah reliabilitas. Sedangkan dalam uji statistik menggunakan uji Man Whitney dengan singnifikan diperoleh dengan nilai asymp.sig.(2-tailed) sebesar 0,002 < 0,05 dari hasil posttest-only control desain kelas eksperimen dan kelas kontrol, skor yang dihasilkan dari kelas eksperimen 1432 sedangkan kelas kontrol 880 dengan nilai rata-rata 32. Maka dari itu bisa disimpulkan bahwa Ha diterima H0 ditolak yang artinya, ada pengaruh pembelajaran kooperatif (STAD) Student Team Achievement Division terhadap literasi numerasi di MI Islamiyah Ngoro Jombang.
PENGARUH MEDIA MATH BINGO TERHADAP HASIL BELAJAR MATERI RASIO KELAS V SDN LARANGAN SORJAN 2
Authors: Mauliyana  , Zahrani Susilo Claudya 
Published: February 2025

The use of innovative learning media is essenstial in helping students comprehend abstract mathematical concepts, including ratio. One of the media that can be utilized is Math Bingo, whish is designed to create an interactive and engaging learning environtment. This study aims to describe the influence of Math Bingo on the learning outcomes of fifth grade students at SDN Larangan Sorjan 2 Klampis Bangkalan in ratio material. The research method employed is a quasi experimental design with a pretest postest control group, involving a sample of 27 fifth grade students at SDN Larangan Sorjan 2 Klampus Bangkalan. Data were collected through observation, interviews, and pretest-postetst techniques. Analysis using t-test yielded a t-value of 1.705619, and with t-table value at df 26 and a significance level of 0,05 being 0,00000030, t-calculated >t-table (1,705619>0,00000030). Additionally, the significance level was less than 0,05 (0,00000030 < 0,05). Thus, according to the t-test criteria , H0 is rejected, and H1 is accepted, indicating a significant influence on the learning outcome of fofth grade students at SDN Larangan Sorjan 2 Klampis Bangkalan
Defining optimal electrospun membranes to enhance biological activities of human endometrial MSCs
Authors: An Jiangru , Ma Tianyi , Wang Qiuhua , Zhang Jinyi , Santerre J. Paul , Wang Wenshuang , Ma Peng , Zhang Xiaoqing 
Published: February 2025

IntroductionHuman endometrial mesenchymal stem cells (H-EMSCs) can inhibit endometrial fibrosis and repair damaged endometrium. However, direct cell injection into dam-aged endometrium shows limited cell survival. Cell seeding onto biomaterial-based electrospun membranes could improve H-EMSCs’ survival and prolong their stay at the damaged endometrium. Polycaprolactone (PCL), silk fibroin (SF) and hyaluronic acid (HA) are synthetic or natural biomaterials used by the biomedicine field, however, their effects on the biological activities of H-EMSCs remain unclear.MethodsIn this study, CD90+CD73+CD45− H-EMSCs were extracted from human endometrium and H-EMSCs showed enhanced adhesion, proliferation on PCL-HA vs. PCL, PCL-SF, establishing the potential of the composite to address cell survival issues.ResultsH-EMSCs cultured on PCL-HA showed decreased IL-6 gene expression and increased IL-10, VEGFA, TGF-β gene expression vs. PCL-SF, establishing the potential to create a favorable micro-environment for generating vascularized endometrial tissues. PCL, PCL-SF, PCL-HA all supported CD90 and Meflin expression of the seeded H-EMSCs, establishing PCL as a platform to form enhanced biomaterial composites for endometrial repair in the future.DiscussionThis study provided significant evidence sup-porting the potential of appropriately tailored composites of PCL and HA to moder-ate inflammation and wound-healing, which can be applied for endometrial tissue repair and regeneration.
Burden, risk factors, and projections of ischemic heart disease in China (1990–2021): findings from the 2021 GBD study
Authors: Xu Sikai , Liu Zhiyang , Tang Mu , Xu Chunli 
Published: February 2025

BackgroundIschemic heart disease (IHD) remains a major public health challenge in China. This study aimed to comprehensively analyze the burden of IHD, its risk factors, and future trends from 1990 to 2021 using the Global Burden of Disease database.MethodsWe assessed IHD trends in incidence, prevalence, mortality, and disability-adjusted life years (DALYs) stratified by age (greater than 15 years) and gender. Age-standardized rates, average annual percentage changes, and joinpoint regression analyses were used to evaluate temporal trends. Decomposition and frontier analyses were conducted to identify key contributors to the IHD burden, while future projections were generated for the next 15 years.ResultsIn 2021, the number of IHD incident cases, prevalent cases, deaths, and DALYs in China were 3.17, 3.25, 3.57, and 2.62 times higher than those in 1990, respectively. Age-standardized mortality rates and age-standardized DALYs rates demonstrated an initial increase, followed by a gradual decline. Males showed higher IHD burden during middle age, while elderly females surpassed males in the later years. Aging, high systolic blood pressure, ambient particulate matter pollution, elevated low-density lipoprotein cholesterol, and smoking were the primary drivers of IHD burden. Future projections suggest a declining incidence and prevalence among males but increasing trends in females, with DALYs expected to rise significantly in the female population.ConclusionsThe burden of IHD in China has evolved significantly over the past three decades, driven by demographic and environmental factors. While prevalence and incidence have risen, mortality and DALYs have shown a recent decline, reflecting shifts in disease patterns. Age and gender disparities are evident, with middle-aged males and elderly females disproportionately affected. Key contributors, such as high blood pressure and pollution, highlight the need for targeted interventions. Gender-specific public health strategies, alongside improved environmental and health policies, are essential to mitigating the future burden of IHD in China.
Impact of physical activity on all-cause mortality in individuals with non-cystic fibrosis bronchiectasis
Authors: Kim Sang Hyuk , Choi Hayoung , Han Kyungdo , Jung Jin-Hyung , Yang Bumhee , Lee Hyun 
Published: February 2025

BackgroundLittle information is available regarding whether active physical activity lowers mortality risk in individuals with bronchiectasis.MethodsWe used the Korean National Health Insurance Service database from 2010 to 2016 to evaluate the association between changes in physical activity and mortality risk in individuals with bronchiectasis. Of 552,510 individuals with newly diagnosed bronchiectasis, we enrolled 165,842 individuals who had two consecutive health examinations before and after bronchiectasis diagnosis, within two years, as the study aimed to measure changes in exercise habits between the two time points. Active physical activity was defined as engaging in moderate- or vigorous-intensity physical activity at least once a week, either before or after bronchiectasis diagnosis. The outcome measure was all-cause mortality.ResultsDuring a mean follow-up of 6.2 ± 2.1 years, 10,535 (6.4%) individuals with bronchiectasis died. Individuals with bronchiectasis who were physically active exhibited a lower mortality rate than those who were physically inactive. Mortality reduction was particularly evident in the exercise maintainers group (aHR [adjusted hazard ratio] = 0.69, 95% confidence interval [CI] = 0.64–0.74) and individuals with physical activity ≥1,000 metabolic equivalent of task-min per week (aHR = 0.73, 95% CI = 0.70–0.77) compared to those who were physically inactive.ConclusionEngaging in active physical activity is associated with a decreased risk of mortality in individuals with bronchiectasis.
Prognostic value of c-MET in oesophageal squamous cell carcinoma: a study based on the mRNA expression in TCGA database and a meta-analysis
Authors: Zhang Qiqi , Li Xiujuan , Li Jian , Zhang Zhiqiang 
Published: February 2025

ObjectiveThis study aims to assess the mesenchymal-epithelial transition factor’s (c-MET) prognostic value in oesophageal carcinoma (ESCA) through a meta-analysis and bioinformatics.MethodsWe analysed c-MET expression in ESCA tissues using data from The Cancer Genome Atlas (TCGA) and conducted a meta-analysis to evaluate its association with clinicopathological factors and survival outcomes. The meta-analysis included studies reporting hazard ratios (HRs) and odds ratios (ORs) for survival and metastatic outcomes.ResultsThe Cancer Genome Atlas analysis revealed elevated c-MET expression in ESCA, which was significantly correlated with lymph node metastasis, tumour grade and stage, though not with overall survival (OS). In the meta-analysis, 278 publications were identified, and 89 duplicates were removed. After screening, 176 articles were excluded, leaving 13 for full-text review. Of these, 5 studies lacked sufficient survival data, resulting in 8 eligible studies with a total of 1,488 patients. Meta-analysis findings indicated that high c-MET expression was associated with worse OS (HR = 1.54, 95% confidence interval [CI]: 1.17–2.01; p = 0.002), distant metastasis (OR = 1.97, 95% CI: 1.14–3.40; p = 0.02) and advanced stage (OR = 2.23, 95% CI: 1.41–3.53; p = 0.0006).ConclusionHigh c-MET expression is associated with poor prognosis and advanced disease in ESCA, highlighting its potential as a biomarker for risk stratification. Further studies are needed to confirm its prognostic value and explore therapeutic implications.
Autism spectrum disorder related phenotypes in a mouse model lacking the neuronal actin binding protein profilin 2
Authors: Witke Walter , Di Domenico Marina , Maggi Laura , Di Nardo Alessia , Stein Valentin , Pilo Boyl Pietro 
Published: February 2025

IntroductionProfilin 2 (PFN2) is an actin binding protein highly expressed in the brain that participates in actin dynamics. It has been shown in vitro and in vivo that in neurons it functions both post-synaptically to shape and maintain dendritic arborizations and spine density and plasticity, as well as pre-synaptically to regulate vesicle exocytosis. PFN2 was also found in protein complexes with proteins that have been implicated in or are causative of autism spectrum disorder.MethodsWe employ a genetically engineered knock-out mouse line for Pfn2 that we previously generated to study the mouse social, vocal and motor behavior in comparison to wild type control littermates. We also study neuronal physiology in the knock-out mouse model by means of cellular and field electrophysiological recordings in cerebellar Purkinje cells and in the Schaffer collaterals. Lastly, we study anatomical features of the cerebellum using immunofluorescence stainings.ResultsWe show that PFN2 deficiency reproduces a number of autistic-like phenotypes in the mouse, such as social behavior impairment, stereotypic behavior, altered vocal communication, and deficits in motor performance and coordination. Our studies correlate the behavioral phenotypes with increased excitation/inhibition ratio in the brain, due to brain-wide hyperactivity of glutamatergic neurons and increased glutamate release not compensated by enhanced GABAergic neurotransmission. Consequently, lack of PFN2 caused seizures behavior and age-dependent loss of cerebellar Purkinje cells, comorbidities observed in a subset of autistic patients, which can be attributed to the effect of excessive glutamatergic neurotransmission.DiscussionOur data directly link altered pre-synaptic actin dynamics to autism spectrum disorder in the mouse model and support the hypothesis that synaptic dysfunctions that asymmetrically increase the excitatory drive in neuronal circuits can lead to autistic-like phenotypes. Our findings inspire to consider novel potential pathways for therapeutic approaches in ASD.
Construction and evaluation of a finger motor feedback system to improve finger dexterity
Authors: Takahashi Shingo , Sakurai Noriko , Kuroiwa Yuki , Takahashi Daishi , Kodama Naoki 
Published: February 2025

IntroductionRecently, a link has been established between cognitive function and hand dexterity in older adults. Declines in cognitive function have been shown to impair performance in finger tapping movements. Research suggest that hand training can improve dexterity, executive function, and cognitive function over time. This underscores the need for effective methods to improve hand and finger dexterity.MethodIn this study, we introduced a new hand training system that provides real-time feedback on finger movements during tapping tasks. We examined the system's impact on the finger dexterity of 32 healthy young participants by using a magnetic sensor finger tapping device (UB-2). During the finger tapping task, the participants performed opening and closing movements either in-phase or anti-phase on both left and right hands for 15 s. They were instructed to tap as quickly as possible. The number of taps, left–right balance, and other relevant data were measured using the UB-2 device.ResultsIn terms of the number of tapping, a significant difference was found between 64.4 without feedback and 68.1 with feedback for the simultaneous opening and closing movements in the dominant hand. In the alternating open-close movement, the significant difference was 50.3 without feedback and 53.4 with feedback. The results showed that the system significantly improved the number and frequency of taps for both hands.ConclusionThe improved tapping performance with feedback suggests that this system can improve hand dexterity.
A multicenter mixed-methods study on the effects of intermittent fasting in patients with immune thrombocytopenia receiving thrombopoietin receptor agonists
Authors: Yassin Mohamed A. , AlRasheed Muna , Al-Eisa Taghreed , Alhashim Noura , Alsayegh Fiasal , Abouzeid Tarek E. , Abd El Fattah Mohamed , Alfili Maryam , Shalaby Neveen , Alotaibi Abdullah , Aljuwaisri Nourah , Almasbahi Anwar , Saleeb Rii , Abdelaziz Hend , Alshurafa Awni , Ismail Omar , Ghasoub Rola 
Published: February 2025

IntroductionIn recent years, significant advances have been made in the treatment of immune thrombocytopenia (ITP) with the development of thrombopoietin receptor agonists (TPO-RAs). TPO-RAs are often used following the failure of prior therapies or when bleeding episodes persist despite glucocorticoid use. In Muslim countries, where religious observance includes 16/8 intermittent fasting, the timing of medication administration may be affected. This study is the first to evaluate the impact of Ramadan fasting on patients receiving different TPO-RAs.MethodsA multicenter mixed-design study was performed in which Muslim patients who fasted during Ramadan while receiving TPO-RAs were interviewed between 2015 and 2023. Patient responses before, during, and after Ramadan were evaluated retrospectively. The bleeding tendency was assessed as (1) no bleeding, (2) minor cutaneous/mucosal bleeding, or (3) severe bleeding that involves major organs.ResultsThe present study included 100 patients from three Muslim countries, including Qatar, Kuwait, and Saudi Arabia, across four tertiary centers. A complete response was observed in 63% of patients on ROM, 46% on ELT and 37% on AVA. For AVA, the mean platelet (PLT) count before Ramadan was estimated at [146.11 ± 111.76], while during Ramadan, it dropped to [131.7 ± 107.6]. For patients on ELT, the mean PLT count before Ramadan was estimated at [120.02 ± 59.7], while during Ramadan, it dropped to [100.8 ± 68.16] (p = 0.016). For patients on ROM, the mean platelet count before Ramadan was estimated at [122.68 ± 80.57], while during Ramadan, it was [130.94 ± 84.96]. Only 3% (3 patients on ELT) experienced bleeding episodes.ConclusionThis study supports the feasibility of Ramadan fasting for ITP patients receiving TPO-RAs. Further studies with a larger sample size are recommended to investigate the impact of other types of fasting on the efficacy and safety of TPO-RAs.
Association of pyridoxal 5′-phosphate (PLP) with lipid profiles: a population-based cohort study
Authors: Zhang Ru-yang , Chen Yue , Yan Xin-Qi , Zhang Yue , Zhou Hua , Feng Qian 
Published: February 2025

ObjectivesThis study aims to explore the correlation between Pyridoxal 5′-Phosphate (PLP) levels and lipid profiles in adult individuals, utilizing data from the National Health and Nutrition Examination Survey (NHANES) database.MethodsThe research included individuals aged 20 years and above, extracted from the NHANES database, covering the period from 2005 to 2010. The primary objective was to scrutinize the relationship between PLP and lipid profiles. This was accomplished by employing weighted, multivariable logistic regression to ascertain these associations. Furthermore, to assess the variability within different demographic segments, interaction analyses were conducted. Additionally, restricted cubic spline (RCS) methodology was implemented to delve into potential nonlinear dynamics between PLP concentrations and lipid levels.ResultsA cohort of 6,459 individuals was included in this study. Our data indicated that 51.60% of the participants were under 50 years old, while 48.40% were over 50, comprising 48.83% males and 51.17% females. PLP levels demonstrated a negative correlation with low-density lipoprotein cholesterol (LDL-C) levels. After controlling for confounding variables, a one-unit increment in PLP correlates with a reduction of 17.7% in LDL-C concentrations (OR: 0.823, 95% CI: 0.823–0.824, p &lt; 0.001). PLP levels exhibited a positive correlation with high-density lipoprotein cholesterol (HDL-C), which increased as PLP levels rose. After controlling for all covariates, a one-unit increase in PLP levels corresponded to a 1.952-fold enhancement in the probability of high HDL-C levels (OR: 1.952, 95% CI: 1.951–1.953, p &lt; 0.001). The relationship between PLP and HDL-C levels was nonlinear. Subgroup analyses indicated that PLP levels and HDL-C concentrations are positively correlated, especially among diabetic patients and non-drinkers.ConclusionPLP levels are inversely associated with LDL-C and positively associated with HDL-C, with stronger effects observed in diabetic patients and non-drinkers. These findings underscore the potential clinical utility of PLP supplementation as a preventive measure against cardiovascular and metabolic diseases.
Sacroplasty with or without screw fixation for sacral metastatic tumors
Authors: Cox Evan P. , Tutton Sean , Scheidt Matthew , Key Brandon M. , Neilson John C. , Wooldridge Adam N. , Bedi Meena , Hackbarth Donald A. , King David M. 
Published: February 2025

IntroductionCementation (sacroplasty) with or without ablation has been shown to improve pain and function for patients with sacral metastatic disease. Percutaneous screw fixation with sacroplasty (PSFS) may provide superior outcomes in select patients.MethodsThirty patients with sacral metastases who underwent sacroplasty with or without ablation and screw fixation at a single institution were retrospectively reviewed. Patients were compared based on treatment (PSFS or sacroplasty alone) and fracture status (pathological or impending) with an ANCOVA. Traumatic fractures were excluded. Patients were followed for 4.4 months on average (range, 2 weeks to 36.5 months). Functional outcomes were assessed using the Musculoskeletal Tumor Society (MSTS) score. The rate of secondary procedures as well as changes in narcotic usage were noted.ResultsPatients with pathological fractures who underwent PSFS demonstrated increased postoperative MSTS scores compared to those who underwent sacroplasty (51% ± 19 versus 25% ± 13, p = 0.005). Patients with impending pathological fractures who underwent PSFS did not demonstrate statistically significant increased postoperative MSTS scores compared to those who underwent sacroplasty alone (38% ± 17 versus 32% ± 12, p = 0.72).DiscussionPSFS may provide additional benefit for patients with pathological fractures, while sacroplasty alone may be sufficient for those with impending pathologic fractures secondary to sacral metastatic disease. This study was limited by its retrospective design and sample size; however, the results may aid in treatment indications for sacral metastases and guide further research Level of Evidence Level III, Therapeutic Study.
Multi-omics analysis identifies a liquid-liquid phase separation-related subtypes in head and neck squamous cell carcinoma
Authors: Zhai Peng-Lei , Chen Meng-Min , Wang Qi , Zhao Jing-Jun , Tang Xiao-Mei , Lu Cui-Ni , Liu Jia , Yang Qin-Xin , Xiang Ming-Liang , Tang Qing-Hai , Gu Biao , Zhang Shu-Ping , Tang Si-Ping , Fu Da 
Published: February 2025

BackgroundGrowing evidence indicates that abnormal liquid–liquid phase separation (LLPS) can disrupt biomolecular condensates, contributing to cancer development and progression. However, the influence of LLPS on the prognosis of head and neck squamous cell carcinoma (HNSCC) patients and its effects on the tumor immune microenvironment (TIME) are not yet fully understood. Therefore, we aimed to categorize patients with HNSCC based on LLPS-related genes and explored their multidimensional heterogeneity.MethodsWe integrated the transcriptomic data of 3,541 LLPS-related genes to assess the LLPS patterns in 501 patients with HNSCC within The Cancer Genome Atlas cohort. Subsequently, we explored the differences among the three LLPS subtypes using multi-omics analysis. We also developed an LLPS-related prognostic risk signature (LPRS) to facilitate personalized and integrative assessments and then screened and validated potential therapeutic small molecule compounds targeting HNSCC via experimental analyses.ResultBy analyzing the expression profiles of 85 scaffolds, 355 regulators, and 3,101 clients of LLPS in HNSCC, we identified three distinct LLPS subtypes: LS1, LS2, and LS3. We confirmed notable differences among these subtypes in terms of prognosis, functional enrichment, genomic alterations, TIME patterns, and responses to immunotherapy. Additionally, we developed the LPRS, a prognostic signature for personalized integrative assessments, which demonstrated strong predictive capability for HNSCC prognosis across multiple cohorts. The LPRS also showed significant correlations with the clinicopathological features and TIME patterns in HNSCC patients. Furthermore, the LPRS effectively predicted responses to immune checkpoint inhibitor therapy and facilitated the screening of potential small-molecule compounds for treating HNSCC patients.ConclusionThis study presents a new classification system for HNSCC patients grounded in LLPS. The LPRS developed in this research offers improved personalized prognosis and could optimize immunotherapy strategies for HNSCC.