bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amitié et amour : passages
Authors: de Mijolla-Mellor Sophie 
Published: April 2024

Le « coup de foudre » qui signe la puissance des affinités électives repose sur la fascination de chacun des protagonistes face à leur mouvement de dessaisissement narcissique envers l’autre. Mais, dès le moment où un couple a constitué une unité isolée, il court le même risque d’étouffement que l’individu et il lui faut sortir de soi pour ne pas tomber malade par stase libidinale, autrement dit par ennui. L’addiction au risque d’aimer à nouveau ailleurs se présente alors, conséquence de l’incapacité à élaborer au sein du couple ce qui peut tenir la place de l’autre. Partant de Goethe et de Stendhal, on interroge ici l’incapacité à se détacher du risque passionnel en la confrontant à la nécessité qu’éprouvent certains sujets de miser leur vie pour la vivre intensément. Face à cette quête narcissique infinie, l’objet se limite à sa capacité de faire défaut, ce qui le rend apte à figurer à l’extérieur du Moi le manque autour duquel il s’organise.
“En avant” : le mot‑clé d’un champion olympique comme instrument psychologique pour l’action sportive
Authors: Laurin-Landry Arnaud , Merri Maryvonne 
Published: April 2024

Dans cet article, nous mettons en action une nouvelle conceptualisation du discours interne à l’aide des méthodes d’analyse élaborées dans un précédent article. Pour ce faire, nous analysons le mot-clé « En avant » que William, champion olympique de ski de bosses, se dit lorsqu’il fait un salto arrière double vrille sur le saut du haut. La description des différentes propriétés du mot-clé « En avant » nous conduit à proposer les trois effets d’un mot-clé : 1) le mot-clé fait apparaître une fonction langagière au sein d’une activité motrice, 2) le mot-clé prend en charge le déploiement des différentes actions possibles et actualise le choix de la bonne action, 3) le mot-clé permet l’apparition d’une rétroaction en direct sur l’action se produisant. La discussion de cet article montre comment les effets du mot-clé n’existent pas en soi dans le mot dit, ils existent par le rapport dialectique entre l’athlète et le mot-clé et sont le produit d’un développement.
Intervenir en situation de crise sociale : l’ergonomie pour créer les conditions d’un dialogue sur le travail
Authors: Pentecôte Baharak , Mollo Vanina , Gaillard Irène 
Published: April 2024

Cet article est issu d’une intervention ergonomique menée au sein d’un établissement hospitalier en proie à une crise sociale. L’objectif était de comprendre l’origine de la crise pour élaborer un diagnostic partagé, et de créer les conditions pour mettre le travail réel au centre des débats et des décisions. Les tensions sociales ont directement impacté la démarche et ont conduit les ergonomes à ajuster leur méthodologie. L’article présente le modèle de compréhension de la crise sociale qui a été co-construit. Il décrit également les ajustements méthodologiques opérés pour faire face aux contraintes de la crise sans cesse renouvelées. Enfin, il montre comment ces ajustements ont permis à la fois de créer les conditions d’un dialogue sur le travail, dans un climat apaisé et d’écoute mutuelle, et d’agir sur le travail.
La contribution des usagères dans un atelier de co‑idéation : une médiation sociotechnique pour l’exploration des niveaux épistémiques d’un projet
Authors: Morvan Aliénor , Safin Stéphane , Dorta Tomás , Détienne Françoise 
Published: April 2024

Cette étude porte sur l’activité de « co-idéation » lors d’un projet de design intérieur. Nous entendons par co-idéation un engagement actif des usagères dans la phase initiale du processus de conception, caractérisée par la génération de propositions de design. Cette approche vise à expliciter leur activité d’usage (actuelle et projetée) en amenant les usagères à appréhender directement un système de représentation et l’espace réel. N’étant pas formées en design, leur contribution nécessite une médiation sociotechnique. Dans cette étude, trois groupes d’usagères collaborent avec des professionnelles de la conception, chargées de stimuler la génération d’idées et de faciliter l’utilisation du système de représentation. Nous cherchons à identifier les contributions des participantes (usagères et médiatrices) par la nature des connaissances mobilisées et construites, que nous structurons en sept « niveaux épistémiques », de l’abstrait au concret. Nous analysons si leur traitement diffère selon la mobilisation du système de représentation, la catégorie des participantes et les tactiques de médiation. L’étude montre que tous les niveaux épistémiques sont explorés, dans une proportion moindre pour ce qui concerne les valeurs et les décisions techniques concrètes. Le positionnement des groupes dans l’espace réel influence leurs propositions et le niveau le plus exploré. Nous identifions plusieurs tactiques de médiation : injonction à la cohérence, impulsion de mouvements verticaux et latéraux. La modélisation d’une tactique de médiation montre la dynamique du soutien apporté. Cette étude établit un cadre théorique opérationnel pour la formation et la médiation de la co-idéation et permet d’élaborer de nouvelles pistes de recherche.
Représenter l’activité pour ouvrir l’exploration et l’imaginaire des concepteurs : le cas de la conception d’artefacts pour la transition agroécologique
Authors: Cerf Marianne , Prost Lorène , Lefeuvre Thibault , Le Du Laura , Gross Hélène 
Published: April 2024

En réponse aux enjeux de durabilité et de transitions dans le monde agricole, de nombreux acteurs, scientifiques et acteurs de la R&D et du conseil agricole, conçoivent des outils ou des services visant à aider les agriculteurs à faire évoluer leurs pratiques agricoles. Ils souhaitent un appui pour intégrer les futurs utilisateurs dans ces processus de conception. Dans cet article, nous confrontons deux interventions que nous avons réalisées auprès de ces acteurs en phase d’exploration d’idées d’outils ou de services, c’est-à-dire très tôt dans la conception. Nous présentons les projets dans lesquels nous sommes intervenus, et la façon dont nous avons représenté l’activité des utilisateurs potentiels afin d’aider les concepteurs à repenser profondément les outils et services imaginés pour soutenir les transitions agroécologiques des agriculteurs. Deux axes ont été privilégiés par nous : une représentation de la diversité des logiques d’action des agriculteurs, une mise en exergue de la dimension systémique et collective des activités à outiller (au sens où elles impliquent bien d’autres acteurs que les agriculteurs). Nous présentons les nouvelles explorations que notre démarche suscite. Nous discutons des enjeux d’évaluation des effets que les supports et plus largement notre démarche ont pu avoir sur la transformation de l’activité des concepteurs. Nous ouvrons également la discussion en pointant la nécessité pour les ergonomes de se doter de méthodes pour représenter une activité en transformation comme celles que mettent en œuvre les agriculteurs qui s’engagent dans des transitions agroécologiques.
Clinicohematological Details of Alcoholics Affected with Dengue: A Retrospective Observation
Authors: Jakribettu Ramakrishna Pai , George Thomas , Pais Micheal L J , Kulkarni Swathi Deepak , Natarajan Srikant , Baliga Manjeshwar Shrinath 
Published: April 2024

Abstract

Introduction:
Dengue is a tropical disease, and alcohol abuse is also common in developing countries in the tropics. Patients with alcoholism and dengue may have more complications due to compromised liver functions. Hence, the changes in hematological and biochemical parameters among alcoholic dengue patients need to be analyzed for warning changes to improve treatment outcomes. The present study was conducted to compare the hematological and biochemical profiles of dengue patients with and without alcoholism.

Materials and Methods:
This was a retrospective study conducted with data from healthy individuals and dengue patients with and without alcoholism. The demographic details, signs and symptoms, and hematological and biochemical (hepatorenal) parameters were studied. The neutrophil-to-lymphocyte ratio, lymphocyte-to-neutrophil ratio, monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio, and systemic immune-inflammation index were studied.

Results:
A total of 252 patients were diagnosed with dengue during the study; 33 (13.09) had known cases of alcohol abuse, and almost equal numbers of age- and sex-matched healthy individuals, i.e., 251, were included in the study. Symptoms such as reduced urine output, melena, skin rashes, retro-orbital pain, and hematuria were observed more often in alcoholic patients than in nonalcoholic dengue patients. The total leukocyte count, MLR, total bilirubin, urea level, and creatinine level were greater, and the platelet (PLT) count and lymphocyte-to-monocyte ratio (LMR) were lower in alcoholic dengue patients than in nonalcoholic dengue patients.

Conclusion:
Compared with those in nonalcoholic dengue patients, the signs and symptoms in alcoholic dengue patients appear to be more aggressive, especially for malena and hematuria. A low PLT, LMR, and elevated total bilirubin, urea, and creatinine in alcoholic dengue patients are considered to be crucial for determining treatment outcomes.
Spontaneous Gram-negative Bacterial Meningitis Following Steroid Therapy for Severe COVID-19
Authors: Ramesh Venkat , Nallamatti Dharani Sathya , Nanda Sagarika , Sharma Ratna Mani 
Published: April 2024

Abstract
This case demonstrates an unusual case of spontaneous Gram-negative bacillary meningitis (GNBM) due to Serratia following COVID-19 and steroid exposure. A 52-year-old male presented with clinical features of acute meningitis following a prolonged hospitalization for severe COVID-19 pneumonia, during which he was administered corticosteroids. Neuroimaging was normal. Cerebrospinal fluid (CSF) analysis revealed high protein, hypoglycorrhachia, and neutrophilic pleocytosis. The Gram stain showed plenty of neutrophils but no bacteria. CSF culture demonstrated convex 1–2 mm colonies, slightly umbonate with entire margins, and opaque. On VITEK2, this was identified as Serratia marcescens and was susceptible to all tested antibiotics. Clinical improvement was noted after 48 h with the administration of meropenem (2 g q8 h) and levofloxacin (750 mg once daily). After a week of treatment, repeat CSF analysis showed a decrease in the CSF protein and total white blood cells, lymphocytic pleocytosis, and an increase in the CSF glucose. The patient made a complete recovery following 3 weeks of antibiotic therapy. This case report highlights that steroids should be used cautiously and judiciously in the COVID-19 setting. Serratia is a rare cause of spontaneous GNBM.
Pattern of liver function test variations in COVID-19 infection & its clinical significance: A study from a dedicated COVID-19 tertiary care centre from India
Authors: Chandnani Sanjay J. , Jain Shubham , Nawghare Pankaj , Debnath Partha , Rane Siddhesh , Deshmukh Rahul , Bansal Saurabh , Patel Sameet , Thanage Ravi , Junare Parmeshwar , Contractor Qais , Rathi Pravin M. , Singh Anupam Kumar 
Published: April 2024

Background & objectives:
Coronavirus disease 2019 (COVID-19) affects respiratory, gastrointestinal, cardiovascular and other systems disease. Studies describing liver involvement and liver function test (LFT) abnormalities are sparse from our population. This study was undertaken to estimate the LFT abnormalities in patients with COVID-19 in a tertiary care set up in India.

Methods:
In this retrospective study conducted at a tertiary care centre in Mumbai, India, all consecutive patients with proven COVID-19 by reverse transcriptase–PCR from March 23 to October 31, 2020 were enrolled. Of the 3280 case records profiled, 1474 cases were included in the study. Clinical characteristics, biochemical parameters and outcomes were recorded.

Results:
Overall 681 (46%) patient had deranged LFTs. Hepatocellular type of injury was most common (93%). Patients with deranged LFTs had more probability of developing severe disease (P<0.001) and mortality (P<0.001). Advanced age (P<0.001), male gender (P<0.001), diabetes mellitus (P<0.001), lower oxygen saturation levels at admission (P<0.001), higher neutrophil–lymphocyte ratio (P<0.001), history of diabetes mellitus and cirrhosiss were associated with deranged LFTs. Acute liver injury was seen in 65 (4.3%) cases on admission and 57 (3.5%) cases during hospital stay. On multivariate analysis for predicting mortality, age >60 yr serum creatinine >2 mg%, PaO2/FiO2 ratio ≤200 and raised AST >50 IU/l (OR: 2.34, CI: 1.59-3.48, P<0.001) were found to be significant.

Interpretation & conclusions:
In COVID-19, LFT abnormalities were common, and derangement increased as severity progressed. The presence of deranged LFT worsens the clinical outcome and predicts in-hospital mortality.
Charting a roadmap for heart failure research in India: Insights from a qualitative survey
Authors: Harikrishnan Sivadasanpillai , Koshy Linda , Ganapathi Sanjay , Jeemon Panniyammakal , Kumar Raman Krishna , Roy Adrija , Reethu S. , Ramachandran Surya , Lakshmikanth L.R. , Sharma Meenakshi , Chopra Vijay Kumar , Prabhakaran Dorairaj , Kartha C.C. 
Published: April 2024

Background & objectives:
Heart failure (HF) is emerging as a major health problem in India. The profile of HF in India is divergent from elsewhere in the world. While cardiologists must equip themselves with the requisite clinical management tools, scientists and health policymakers would need epidemiological data on HF and information on the resources required to meet the challenges ahead. The aim of this study was to identify the lacunae and to suggest recommendations to improve HF research.

Methods:
We surveyed a multidisciplinary group of HF experts using a two stage process. An email-based survey was conducted using a structured questionnaire, followed by an online discussion. The experts prioritized the major challenges in convergence research in India and inter-rater agreement values were calculated. In addition, they enlisted potential research gaps and barriers in the domains of epidemiology, diagnostics, management and technology and suggested recommendations to overcome those barriers.

Results:
The experts identified a paucity of data on HF burden, lack of state-of-the-art diagnostic facilities and trained personnel, overt dependence on imported devices/equipment/reagents, lack of interaction/awareness/information among stakeholders and lack of biobanks, as major barriers in HF research. Three fourths of the experts agreed that lack of interaction among stakeholders was the major challenge with the highest inter-rater agreement in both stages (19 out of 25 and 11 out of 17, respectively). The experts recommended the creation of multidisciplinary taskforces dedicated to population sciences, data sciences, technology development and patient management with short-, intermediate- and long-term strategies.

Interpretation & conclusions:
The study generated a wish list for advances in HF research and management, and proposed recommendations for facilitating convergence research as a way forward to reduce the burden of HF in India.
Role of serum microRNAs as biomarkers for endometriosis, endometrioid carcinoma of ovary & endometrioid endometrial cancer
Authors: Kumari Priti , Sharma Indu , Saha Subhas Chandra , Srinivasan Radhika , Bhardwaj Puneet 
Published: April 2024

Background & objectives:
Accurate and early diagnosis is imperial in the management of endometriosis, endometrioid carcinoma of ovary (ECO) and endometrioid endometrial cancer (EC), yet there are no definitive diagnostic methods available for these diseases. Therefore, the present study was aimed to evaluate the diagnostic potential of differentially expressed miRNAs in serum samples of women with endometriosis, ECO and EC to establish them as diagnostic biomarkers.

Methods:
Blood samples (5 ml) were obtained from 40 patients (n=10/study group) undergoing laparoscopy/laparotomy/hysterectomy. miRNA-rich RNA was extracted from the serum samples, and quantitative real-time (qRT)-PCR was performed to check the expression levels of miR-16, miR-99b, miR-20a, miR-145, miR-143 and miR-125a in all the samples. Receiver operating characteristic (ROC) curve analysis was done to check the diagnostic potential.

Results:
In endometriosis, miR-16 was downregulated (P<0.05) whereas miR-99b, miR-125a, miR-143 and miR-145 were upregulated (P<0.05). In ECO group, downregulated expression of miR-16 and miR-125a (P<0.05) was observed, whereas miR-99b, miR-143 and miR-145 were upregulated (P<0.05). In endometrioid EC, miR-16, miR-99b, miR-125 and miR-145 were downregulated (P<0.05), whereas miR-143 was upregulated (P<0.05). ROC curve analysis showed that, for endometriosis, miR-99b, miR-125a, miR-143 and miR-145 served as diagnostic markers. miR-145 showed diagnostic power for ECO, and for endometrioid EC, miR-16, miR-99b, miR-125a and miR-145 showed diagnostic potential.

Interpretation & conclusions:
The present findings suggested that certain circulating miRNAs (miB99b, miR-16, miR-125a, miR-145) might act as indicators and discriminators of endometriosis and endometrioid subtypes of EC and ovarian cancer and might serve as potential biomarkers for early diagnosis and management of these debilitating diseases.
Bacteriophages as therapeutic & disinfectant agents to tackle multidrug-resistant Acinetobacter baumannii
Authors: Rathor Nisha , Bahadur Tej , Thakur Chandan Kumar , Bamola Vishwa Deepak , Das Bimal Kumar , Chaudhry Rama 
Published: April 2024

Background & objectives:
Multidrug-resistant (MDR) Acinetobacter baumannii is a serious threat for human health worldwide. The studies on agents targeting A. baumannii are imperative due to identified A. baumannii co-infections in COVID-19. Bacteriophages are promising antibacterial agents against drug-resistant bacteria. This study intended to isolate bacteriophages against MDR A. baumannii from the water of river Ganga, to be used potentially as therapeutic and disinfectant particles.

Methods:
Acinetobacter phages were isolated from the Ganga water collected from Kanpur and further tested on 50 MDR A. baumannii isolates to determine host range. The phages were morphologically characterized by transmission electron microscopy. The disinfectant property of the isolated phages was tested by spraying of bacteriophage cocktail on MDR A. baumannii contaminated plastic surface, analyzed by colony-forming unit (CFU) and bioluminescence assay (adenosine triphosphate monitoring).

Results:
A total of seven bacteriophages were isolated against MDR A. baumannii. The bacteriophages lysed three MDR A. baumannii isolates out of 50 tested, showing narrow host range. Electron microscopy revealed hexagonal heads and long tails of bacteriophages, belonging to order Caudovirales. The bacteriophage cocktail reduced the MDR A. baumannii load efficiently on plastic surface, evidenced by reduction in CFUs and bioluminescence.

Interpretation & conclusions:
The findings of this study suggest that the isolated bacteriophages are potential lytic agents for MDR A. baumannii clinical isolates, and may be used as potential therapeutic agents as well as disinfectant to combat MDR A. baumannii with due consideration to phage host specificity, with further characterization.
Prevalence & correlates of COVID-19 vaccine hesitancy in a rural community of Bengaluru district, southern India: A preliminary cross-sectional study
Authors: Mundackal Rose , Agarwal Twinkle , Murali Karthikk , Isaac Natasha V. , Hu Patricia , Dhayal Vishal , Mony Prem K. 
Published: April 2024

Background & objectives:
Studying vaccine hesitancy is important for helping improve vaccine coverage against COVID-19. The objective of this study was to assess the prevalence and correlates of COVID-19 vaccine hesitancy in a rural community in India.

Methods:
A cross-sectional study of all adults aged over 18 yr was undertaken during July-August 2021, in a village outside Bengaluru city in southern India.

Results:
In our study, 68.7 per cent of the eligible 297 adult population accepted vaccination immediately, another 9.4 per cent hesitated but accepted vaccination without delay, a further 10.4 per cent delayed their vaccination and the remaining 11.5 per cent refused vaccination. The prevalence (95% confidence interval) of vaccine hesitancy was 21.9±4.8 per cent. Full vaccination was higher among males (76%) compared to females (58%, P<0.001). Those who hesitated and delayed vaccination (converts) were more likely to be from a nuclear family, whereas those who refused the vaccine were from a joint/three-generation family. Those who refused vaccination were adversely influenced by social media predominantly as also their religious/cultural beliefs and distrust on the pharmaceutical industry. Those who delayed but accepted vaccination were positively influenced by healthcare professionals and others who had accepted the vaccine recently. Geographic factors, cost of vaccine, and mode of administration were not the major concerns.

Interpretation & conclusions:
Vaccine uptake is a continuum. Our study helped identify the characteristics of those who delayed vaccination versus those who refused vaccination. This will help policymakers, programme managers and healthcare professionals to focus priority action on population subgroups for improving individual- and population-level protection.
Cost of screening, out-of-pocket expenditure & quality of life for diabetes & hypertension in India
Authors: Brar Sehr , Kaur Gunjeet , Muniyandi Malaisamy , Karikalan Nagarajan , Bano Henna , Bhansali Anil , Jain Sanjay , Kumari Savita , Prinja Shankar 
Published: April 2024

Background & objectives:
The Government of India has initiated a population based screening (PBS) for noncommunicable diseases (NCDs). A health technology assessment agency in India commissioned a study to assess the cost-effectiveness of screening diabetes and hypertension. The present study was undertaken to estimate the cost of PBS for Type II diabetes and hypertension. Second, out-of-pocket expenditure (OOPE) for outpatient care and health-related quality of life (HRQoL) among diabetes and hypertension patients were estimated.

Methods:
Economic cost of PBS of diabetes and hypertension was assessed using micro-costing methodology from a health system perspective in two States. A total of 165 outpatients with diabetes, 300 with hypertension and 497 with both were recruited to collect data on OOPE and HRQoL.

Results:
On coverage of 50 per cent, the PBS of diabetes and hypertension incurred a cost of

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45.2 per person screened. The mean OOPE on outpatient consultation for a patient with diabetes, hypertension and both diabetes and hypertension was

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4381 (95% confidence interval [CI]: 3786-4976),

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1427 (95% CI: 1278-1576) and

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3932 (95% CI: 3614-4250), respectively. Catastrophic health expenditure was incurred by 20, 1.3 and 14.8 per cent of patients with diabetes, hypertension and both diabetes and hypertension, respectively. The mean HRQoL score of patients with diabetes, hypertension and both was 0.76 (95% CI: 0.72-0.8), 0.89 (95% CI: 0.87-0.91) and 0.68 (95% CI: 0.66-0.7), respectively.

Interpretations & conclusions:
The findings of our study are useful for assessing cost-effectiveness of screening strategies for diabetes and hypertension.