bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rule Based Mamdani Fuzzy Inference System to Analyze Efficacy of COVID19 Vaccines
Authors: Mittal Poonam , Abirami S P , Ramya Puppala , J Balajee , Muniyandy Elangovan 
Published: March 2024

INTRODUCTION: COVID-19 was declared as most dangerous disease and even after maintaining so many preventive measures, vaccination is the only preventive option from SARS-CoV-2. Vaccination has controlled the risk and spreading of virus that causes COVID-19. Vaccines can help in preventing serious illness and death. Before recommendation of COVID-19 vaccines, clinical experiments are being conducted with thousands of grown person and children. In controlled situations like clinical trials, efficacy refers to how well a vaccination prevents symptomatic or asymptomatic illness.
OBJECTIVES: The effectiveness of a vaccine relates to how effectively it works in the actual world.
METHODS: This research presents a novel approach to model the efficacy of COVID’19 vaccines based on Mamdani Fuzzy system Modelling. The proposed fuzzy model aims to gauge the impact of epidemiological and clinical factors on which the efficacy of COVID’19 vaccines.
RESULTS: In this study, 8 different aspects are considered, which are classified as efficiency evaluating factors. To prepare this model, data has been accumulated from various research papers, reliable news articles on vaccine response in multiple regions, published journals etc. A set of Fuzzy rules was inferred based on classified parameters. This fuzzy inference system is expected to be of great help in recommending the most appropriate vaccine on the basis of several parameters.
CONCLUSION: It aims to give an idea to pharmaceutical manufacturers on how they can improve vaccine efficacy and for the decision making that which one to be followed.
Prediction model for hepatitis B e antigen seroconversion in chronic hepatitis B with peginterferon-alfa treated based on a response-guided therapy strategy
Authors: Zhang Pei-Xin , Zheng Xiao-Wei , Zhang Ya-Fei , Ye Jun , Li Wei , Tang Qian-Qian , Zhu Jie , Zou Gui-Zhou , Zhang Zhen-Hua 
Published: March 2024

BACKGROUND
Models for predicting hepatitis B e antigen (HBeAg) seroconversion in patients with HBeAg-positive chronic hepatitis B (CHB) after nucleos(t)ide analog treatment are rare.
AIM
To establish a simple scoring model based on a response-guided therapy (RGT) strategy for predicting HBeAg seroconversion and hepatitis B surface antigen (HBsAg) clearance.
METHODS
In this study, 75 previously treated patients with HBeAg-positive CHB underwent a 52-week peginterferon-alfa (PEG-IFNα) treatment and a 24-wk follow-up. Logistic regression analysis was used to assess parameters at baseline, week 12, and week 24 to predict HBeAg seroconversion at 24 wk post-treatment. The two best predictors at each time point were used to establish a prediction model for PEG-IFNα therapy efficacy. Parameters at each time point that met the corresponding optimal cutoff thresholds were scored as 1 or 0.
RESULTS
The two most meaningful predictors were HBsAg ≤ 1000 IU/mL and HBeAg ≤ 3 S/CO at baseline, HBsAg ≤ 600 IU/mL and HBeAg ≤ 3 S/CO at week 12, and HBsAg ≤ 300 IU/mL and HBeAg ≤ 2 S/CO at week 24. With a total score of 0 vs 2 at baseline, week 12, and week 24, the response rates were 23.8%, 15.2%, and 11.1% vs 81.8%, 80.0%, and 82.4%, respectively, and the HBsAg clearance rates were 2.4%, 3.0%, and 0.0%, vs 54.5%, 40.0%, and 41.2%, respectively.
CONCLUSION
We successfully established a predictive model and diagnosis-treatment process using the RGT strategy to predict HBeAg and HBsAg seroconversion in patients with HBeAg-positive CHB undergoing PEG-IFNα therapy.
Research Data Management Competencies for Academic Libraries: Perspectives from Two Universities in South Africa
Authors: Badenhorst Patricia , Raju Jaya 
Published: March 2024

The rapid pace of technological change has significantly transformed the librarianship profession, impacting the required competencies for professionals working in library and information services (LIS). As new roles emerge within academic libraries, librarians need to assess their current knowledge and skills as well as identify additional knowledge and skills needed to adapt to evolving roles and responsibilities. This paper reports findings of a study conducted at two university libraries in South Africa. The objective of the study was to identify the competencies necessary for academic librarians in providing research data management services (RDM). While previous studies have explored the knowledge and skills required for academic librarians in Southern Africa and globally, there is a research gap concerning the specific competencies necessary for RDM. This study employed semi-structured interviews with librarians from two selected university libraries, using purposive sampling. The research also included document reviews and content analysis of relevant academic library job advertisements. The study’s findings highlight key competencies such as information and data management practices, repository management, data curation, data collection management, understanding funders’ policies, research Research Data Management Competencies for Academic Libraries: Perspectives from Two Universities in South Africa methods and processes, as well as ICT and digitization skills. The findings also highlight the importance of robust training and selfdevelopment through online courses, webinars, and freely available materials as strategies to support RDM.
The Role of Semantic Web Technologies in Improving Knowledge Management Systems
Authors: Shalom Gracie 
Published: March 2024

Purpose: The general purpose of this study was to investigate the role of semantic web technologies in improving knowledge management systems.
Methodology: The study adopted a desktop research methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library.
Findings: The findings reveal that there exists a contextual and methodological gap relating to role of semantic web technologies in improving knowledge management systems. Preliminary empirical review revealed that that semantic web technologies significantly enhanced knowledge management systems across diverse industries, facilitating better organization, integration, and retrieval of knowledge resources. Adoption of these technologies addressed key challenges such as information overload and semantic heterogeneity, leading to increased discoverability, interoperability, and reuse of knowledge assets. However, successful implementation required considerations of factors like organizational readiness and user acceptance, necessitating investments in training, support, and change management strategies. Overall, semantic web technologies improved knowledge management practices and enhanced organizational competitiveness in the knowledge-driven economy.
Unique Contribution to Theory, Practice and Policy: The Social Constructionism theory, Cognitive Load and Diffusion of Innovation may be used to anchor future studies on semantic web technologies. The study recommended that organizations invest in semantic web technologies for knowledge management, prioritize user-friendly KMS, foster a culture of collaboration, establish robust governance, and monitor KMS performance. These measures ensured effective knowledge sharing, decision-making, and innovation, enhancing organizational competitiveness and success.
Extranjeros entre cómic y manga: el gaijin manga y la obra de Vicenzo Filosa
Authors: Quaianni Manuzzato Lisa Maya 
Published: March 2024

Uno de los fenómenos más interesantes en el cómic reciente es el surgimiento, en diferentes países, de autores que, como migrantes entre diferentes culturas del noveno arte, se remontan a la producción manga en estética y narración, manejándola con su propio estilo y mezclándola a historias y temáticas de sus culturas. El término gaijin manga es una etiqueta, quizás imperfecta, que identifica artistas que tienen en común un producción underground y vanguardista, a menudo conectada con la autoedición.
La investigación pretende explicar qué se entiende por narrativa gráfica inspirada en los mangas, haciendo una rápida panorámica de las características de sus autores, como el argentino Berliac. Posteriormente, el núcleo del texto se enfocará en el italiano Vincenzo Filosa, punto de convergencia entre la tradición gekiga (cómic japonés de temática más realista), el cómic autoeditado e independiente italiano y el gaijin manga.
Assessment of the correlation between the occurrence of fine movements of the hand, pre-frailty, and body composition in the elderly
Authors: Sebastjan Anna , Kołodziej Małgorzata , Skrzek Anna , Ignasiak Zofia 
Published: March 2024

PurposeThe main objective of the study was to evaluate the correlations between fine movements of the hand, the tissue composition of the upper limb, and the occurrence of frailty syndrome in elderly people in the Polish population.MethodsThe study included 998 individuals living alone aged 60 to 87 years. Anthropometric and bioelectrical impedance measurements were taken, tests of motor skills of the upper limbs and functional efficiency were performed, and the phenotype of physical weakness was assessed.ResultsParticipants identified as pre-frailty were observed to score less favourably in motor skills tests compared to other participants. The significance of the differences between the males and females was confirmed for most tests of precision, coordination, and speed of the upper limbs, in addition to the number of aiming errors. A correlation was observed between reduced fine movements of the hand and age, reduced functional efficiency, and low muscle mass of the upper limbs. Of all the included hand motor tests, only hand tremor scores in the stability test did not affect the risk of pre-frailty.ConclusionsThe study showed a significant, positive correlation between the fine movements of the hand, mainly with the weight and strength of the muscles of the upper limb, and negative in the case of the risk of frailty syndrome. It is advisable to focus on programs to raise awareness of the importance of physical activity, which translates into health and quality of life.
ОБОСНОВАНИЕ ФУНКЦИОНАЛЬНОСТИ ТРАКТОРНОГО ПРИЦЕПА ПРИ ЗАГОТОВКИ СИЛОСА ВАКУУМНЫМ СПОСОБОМ
Authors: Жумагалиев Е. Р. , Сералы Б. Ұ. , Хазимов Ж. М. , Хазимов К. М. 
Published: March 2024

В молочном скотоводстве основную долю рациона занимают сочные корма, включая силос, доля которго может составлять - 65%. Однако из-за несовершенства методов заготовки силоса происходят значительные потери кормов от 5 до 35 % в зависимости от способа зоготовки и хранения. В статье представлена функциональность двухосного грузового прицеп трактора путем комплектования техническими средствами для ваккумирования силосной массы из под комбайна. Представлен алгоритм процесса ваккумирования силосной массы состоящий из 6 операций мобильного агрегата. По результатам исследований в зависимости от времени получены хронометражные данные выполняемые техническими средствами агрегата. Наиболее продолжительной операцией по времени заготовки, составило вакуумирование мягких контейнеров равыным - 14 минут 40 секунд. Операция по загрузки измельченной массы является самой быстрой составляющая - 1 минуту 32 секунды. Данный показатель зависит от урожайности поля а также производительности кормоуборочного комбайна.
Profile of pyoderma in dermatology outpatient departement at Sanglah General Hospital Denpasar, Bali-Indonesia period January 2016 until December 2017
Authors: Ni Luh Putu Ratih Vibriyanti Karna  , Dewi Gotama  , Sissy  
Published: March 2024

Introduction: Pyodermas are infections in the epidermis, just below the stratum corneum or in hair follicles. It is most common in children, although it can also affect adults. Pyoderma often found in tropic areas. Pyoderma is caused by Staphylococcus, Streptococcus, or both. This study aimed to identify the profile of pyoderma in Dermatology Outpatient Department at Sanglah General Hospital Denpasar Periods January 2016 – December 2017.
Method: Study design using descriptive retrospective model, done by taking data from daily visit record in Dermatology Outpatient Department at Sanglah General Hospital Denpasar Periods January 2016 – December 2017.
Result: Pyodermas is one of the common skin problems observed in patients attending dermatology OPD. The number of new cases in pyoderma is 202 cases (7,32%), often found in males and 0-5 years age group (35,64%). The diagnosis of furuncle is the most finding type of pyoderma and the most commonly given therapy is a combination therapy of systemic antibiotics with topical. Co-amoxiclav is the most common drug that uses orally and fusidic acid as topical ointment.
Conclusion: pyoderma remains as the most common skin infection in dermatology outpatient department at Sanglah General Hospital, Bali-Indonesia.
Introduction: Pyodermas are infections in the epidermis, just below the stratum corneum or in hair follicles. It is most common in children, although it can also affect adults. Pyoderma often found in tropic areas. Pyoderma is caused by Staphylococcus, Streptococcus, or both. This study aimed to identify the profile of pyoderma in Dermatology Outpatient Department at Sanglah General Hospital Denpasar Periods January 2016 – December 2017.
Method: Study design using descriptive retrospective model, done by taking data from daily visit record in Dermatology Outpatient Department at Sanglah General Hospital Denpasar Periods January 2016 – December 2017.
Result: Pyodermas is one of the common skin problems observed in patients attending dermatology OPD. The number of new cases in pyoderma is 202 cases (7,32%), often found in males and 0-5 years age group (35,64%). The diagnosis of furuncle is the most finding type of pyoderma and the most commonly given therapy is a combination therapy of systemic antibiotics with topical. Co-amoxiclav is the most common drug that uses orally and fusidic acid as topical ointment.
Conclusion: pyoderma remains as the most common skin infection in dermatology outpatient department at Sanglah General Hospital, Bali-Indonesia.
The effectiveness of galactomyces ferment filtrate, dexpanthenol, and Centella asiatica combination serum in the treatment of post-acne hyperpigmentation
Authors: We Sagara Dewi  , Ivan Kurniadi  , Anis Irawan Anwar  
Published: March 2024

Background: Acne vulgaris is a chronic inflammation of the pilosebaceous gland that may result in non-inflammatory and inflammatory lesions. A hypermelanotic reaction to skin inflammation causes post-acne hyperpigmentation (PAH). It can occur secondary to the inflammation process and, depending on the severity, may persist for a prolonged period.
Objective To determine the effectiveness of galactomyces ferment filtrate (GFF), dexpanthenol, and Centella asiatica combination serum in the treatment of PAH
Methods: This was a placebo-controlled randomized clinical trial. Sixty-eight subjects were divided into two groups: the experimental group received combination serum while the control group received a placebo for eight weeks. Three drops of serum were applied to the area with PAH twice daily in the morning and night. The melanin, erythema, roughness, and L*, a*, and b* scores were assessed objectively using mexameter, chromameter and skin analyzer every two weeks. Pearson’s correlation test and independent T-test were used to assess the trend of the parameters and compare the results of both groups.
Results: The results of statistical calculations using the Pearson correlation test showed the treatment group showed a significant decreasing trend of the melanin and spots score. Both groups showed a significant decreasing trend in erythema, L* score and roughness. However, no significant difference was found between both groups in all parameters.
Conclusion: The combination serum may decrease the melanin and spot scores suggesting that it affects the melanocyte activity. It has shown good efficacy in treating PAH.
Steven johnson syndrome induce by carbamazepine in epileptic patient: a case report
Authors: Nyoman Yoga Maya Pramita  , Prima Saraswati Sanjiwani Sudarsa  , Ratih Purnamasari Nukana  
Published: March 2024

Introduction: Steven Johnson Syndrome (SJS) is life-threatening skin reaction, it is a mucocutaneous disorder induced by immune complex-mediated hypersensitivity reaction. Most frequent offending agents are antibiotic, antiretroviral and aromatic anticonvulsants. Problems arise when these drugs are required for long-term use and necessary for several health conditions. These case series aim to describe SJS and provide replacement therapy especially inpatient with epilepsy.
Case report: A 37 years old female was consulted from neurology department with chief complaints an erythematous rash on her chest, back upper and lower extremities accompanied with fever, the patient also complaint erosions on her lips. She had history of seizure and was prescribe Carbamazepine. Carbamazepine was replaced and patient treated with dexamethasone intravenously. After 1 week of admitted there is an improvement.
Conclusion: Steven Johnson Syndrome (SJS) is a life-threatening disease, the replacement of the suspected drugs and appropriate therapy can improve the prognosis of patient.
Incidence and characteristic of psoriasis patients at Sanjiwani Gianyar Regional Hospital 2018-2019
Authors: Annisa Alviariza  , Sayu Widyawati  
Published: March 2024

Introduction: Psoriasis is a chronic inflammatory skin disease characterized by firmly demarcated red plaque covered by a thick squama due to impaired proliferation and differentiation of the epidermis. Diagnosis of psoriasis is based on history taking and clinical features. Treatment is determined based on the patient's clinical characteristics and the severity of the disease. This retrospective study aims to determine the incidence, characteristics, and treatment options of psoriasis patients in the Dermatology and Venereology Polyclinic of Sanjiwani Gianyar Regional Hospital in 2018-2019.
Methods: A retrospective study of psoriasis patients at Sanjiwani Gianyar Regional Hospital in 2018-2019. Data collected from medical records includes sociodemographic data, clinical data, and patient treatment history.
Results: Within two years, there were 53 cases of psoriasis. The dominance of psoriasis cases was found in men with a ratio of women and men 1:2.31. Of total 53 patients, 37 were male (69.81%)and 16 female patients (30.19%). The most common type was psoriasis vulgaris (73.58%). The most age group was 31-45 years. The most commonly given regimen of therapy was topical corticosteroids plus oral antihistamines (45.28%). The most widely given systemic therapy was methotrexate. Accompanying skin infections were found in 6 cases of psoriasis (11.32%).
Conclusion: Based on the results of the study, there were 53 new cases of psoriasis in 2018-2019, psoriasis vulgaris was the most common, the most age group was 31-45 years old, topical corticosteroids with antihistamines were still the main treatment options for psoriasis patients in Sanjiwani Gianyar Regional Hospital.
Case report: a child with type 1 neurofibromatosis and intellectual disability
Authors: Elice Wijaya  , Ni Luh Putu Ratih Vibriyanti Karna  , Ida Ayu Uttari Priyadarshini  
Published: March 2024

Background: Neurofibromatosis is a genetic disorder that manifests as a tumor surrounding the nerves and several other pathologic presentations.
Case: Female, 11 years old, according to history, physical examination and supporting the investigation, was consistent with the diagnostic criteria of type 1 neurofibromatosis (NF-1). The patient also has an intellectual disability. A tumor on the foot region that was functionally disabling was found on the patient, and surgical treatment was performed. Cognitive disorder is the most common neurological complication in individuals with NF-1 and usually presents with a low intelligence quotient (IQ). There is no specific treatment to prevent the development of NF-1. However, early treatment can minimize and prevent further complications. Treatment for the patient involves multiple clinical disciplines.
Conclusion: A neurofibromatosis case can be diagnosed clinically alone, since many other systemic involvements require a multi-disciplinary approach.
Cyclooxygenase-2 as potential intervention target of leprosy reactions: a systematic review
Authors: Rusyati Luh Made Mas , Sari Luh Gede Melia Puspita , Winaya Ketut Kwartantaya 
Published: March 2024

Background: Leprosy reaction is an acute inflammatory of leprosy complication that potentially cause disability. Prompt and appropriate treatment is needed to prevent this permanent neurological complication. As inflammation of this reaction is mediated by cyclooxygenase-2 (COX-2), therefore targeting this substance may potential to prevent disability. This systematic review aimed to define COX-2 as a potential target of intervention in leprosy reaction.
Method: Medline, Cochrane library, PubMed, and Google scholar databases were searched for articles published at any time. Observational study and clinical trial, comparative, prospective, retrospective, and descriptive study were extracted, analyzed, and discussed.
Results: We found 6 studies that met the inclusion and exclusion criteria, with 104 participants with leprosy reactions and 143 comparators included in this review. In leprosy reactions, COX-2 expression was found in the vessels and nerves of the dermis and subcutis. Macrophages are cell mostly abundantly expressing COX-2. The COX-2 expression was found higher in the leprosy reaction compare to the non-leprosy reaction. Genetically, genes PTGS2 and TNFAIP6 encode COX-2 production also tend to increase especially in type 1 reaction.
Conclusions: Preclinically and genetically, COX-2 is a potential target for intervention of leprosy reaction.
The high homeostatic model assessment of insulin resistance as risk factor for acne vulgaris
Authors: I Gusti Ayu Agung Praharsini  , Anak Agung Gde Putra Wiraguna  , Stefani Nurhadi  
Published: March 2024

Background: Acne vulgaris (AV) is a common chronic skin disease involving blockage and or inflammation of pilosebaceous glands which usually affects teenagers and young adults. Elevated sebaceous gland secretion, Propionibacterium acne colonization and inflammation, high androgen effects, and follicular hyperproliferation are the main pathogenic factors of AV. IGF-1 and insulin were studied to stimulate sebaceous lipogenesis. In the skin, besides inducing lipid production in human sebocytes IGF-1 also induces keratinocyte proliferation in vitro and in vivo. HOMA-IR is an examination to determine insulin activity in the basal state.
Objective: To prove that high HOMA-IR value is a risk factor for the occurrence of acne vulgaris.
Methods: This study is a case control analytic study by comparing HOMA-IR in subjects with AV (case group) and non AV (control group). AV is diagnosed based on clinical predilection. Insulin testing was carried out by the immulite 2000 device through the immunochemiluminescent method.
Results: Mean HOMA-IR of case group is 2.63 ± 0.29 meanwhile in the control group was 1.71 ± 0.26 (p <0.001). Subjects with high HOMA-IR had 4.8 times higher risk to experience AV compared to patients with normal HOMA-IR values (p <0.001; 95% CI 2.765-8.332).
Conclusion: HOMA-IR values in acne patients were higher than controls. A high HOMA-IR value is an AV risk factor.