bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ovarian surveillance including endometrial cytology for patients with hereditary breast and ovarian cancer before risk‐reducing salpingo‐oophorectomy: A retrospective analysis
Authors: Fusegi Atsushi , Nomura Hidetaka , Ueki Arisa , Abe Akiko , Kamata Mayumi , Misaka Satoki , Aoki Yoichi , Tanigawa Terumi , Yunokawa Mayu , Kanao Hiroyuki 
Published: March 2024

AbstractAimOvarian surveillance in women with hereditary breast and ovarian cancer who do not undergo risk‐reducing salpingo‐oophorectomy has been controversial. Therefore, this study aimed to demonstrate the clinical features of ovarian surveillance at our institution using a technique that combines serum cancer antigen 125 measurements, transvaginal ultrasonography, and uterine endometrial cytology.MethodsWe retrospectively examined 65 women, who had not undergone risk‐reducing salpingo‐oophorectomy diagnosed with hereditary breast and ovarian cancer between 2000 and 2021 at our hospital. Clinical information was obtained and analyzed through a chart review. The details of the treatment course were reviewed for patients who had developed ovarian cancer.ResultsOverall, 5 of the 65 women were diagnosed with ovarian cancer based on abnormal findings during periodic surveillance. All patients who developed ovarian cancer were asymptomatic, even if the cancer was at an advanced stage. Two of the 65 patients had endometrial cytology abnormalities, both of whom had ovarian cancer. All patients who developed ovarian cancer underwent primary debulking surgery, and complete gross resection was achieved. None of the patients experienced ovarian cancer recurrence.ConclusionsThe ovarian surveillance strategy at our institution for women with hereditary breast and ovarian cancer who do not undergo risk‐reducing salpingo‐oophorectomy can identify asymptomatic ovarian cancer and contribute to achieving complete gross resection during primary surgery. Ovarian surveillance may contribute to a reduction in ovarian cancer mortality.
Illusions of textuality: The semiotics of literary memes in contemporary media
Authors: Lee Tong King 
Published: March 2024

AbstractThis article seeks to account for the phenomenon where cultural productions are able to transcend different chronotopes and masquerade in myriad forms while sustaining an illusion of itself as a text. Using the Barthian distinction between work and Text as its framework, the article argues that multimodal semiotics offers a theoretically viable perspective on the global circulation of cultural artifacts by way of the concepts of memes, distribution, resemiotization, and assemblage. The central argument is this: what we call a text in common parlance is in fact a node within a networked assemblage of individually constituted works loosely connected through a substrate recognizability of memes. Operating at the level of this network is the Barthian Text that is always in‐progress and can never really be completed. The article concludes by proposing that with the imminence of Web 5.0 and in light of the ever‐pervasive influence of artificial intelligence in cultural production, it is imperative that we adopt nonlinear thinking to understand the shifting semioscapes in digital space and their impact on contemporary textuality.
But life goes on: drama classes, Ukrainian refugees, and Icelandic language learning
Authors: Tavares Vander , Benediktsson Artëm Ingmar 
Published: March 2024

AbstractThis paper explores the relationship between additional language (L2) literacy development and drama plays based on the experiences of adult refugees from Ukraine in Iceland. This inquiry is guided by the following questions: What are the learners' experiences and perceptions of drama classes in relation to their literacy development in Icelandic as an L2? What role might engaging in drama classes have when it comes to learners' sense of well‐being? We employ a multiliteracies perspective, which has pluralised the traditional view of literacy and offered new insight into literacy teaching and learning by integrating multimodal, multi‐sensorial, and critical practices into literacy education. The findings originate from a qualitative, interview‐based study with five Ukrainian learners of a refugee background in Iceland. Findings suggest that learning Icelandic through drama afforded the learners an opportunity to learn Icelandic in creative, engaging, and meaningful ways. Furthermore, learning Icelandic through drama supported the enactment and development of essential capacities for personal and professional growth, such as open‐mindedness, tolerance, respect, and collaboration. Many of the learners felt positively challenged to try out something new. This paper concludes with a discussion on the importance of critical, experiential L2 education that acknowledges learners' diverse lived experiences.
An essential protease,FtsH, influences daptomycin resistance acquisition inEnterococcus faecalis
Authors: Nair Zeus Jaren , Gao Iris Hanxing , Firras Aslam , Chong Kelvin Kian Long , Hill Eric D. , Choo Pei Yi , Colomer‐Winter Cristina , Chen Qingyan , Manzano Caroline , Pethe Kevin , Kline Kimberly A. 
Published: March 2024

AbstractDaptomycin is a last‐line antibiotic commonly used to treat vancomycin‐resistant Enterococci, but resistance evolves rapidly and further restricts already limited treatment options. While genetic determinants associated with clinical daptomycin resistance (DAPR) have been described, information on factors affecting the speed of DAPRacquisition is limited. The multiple peptide resistance factor (MprF), a phosphatidylglycerol‐modifying enzyme involved in cationic antimicrobial resistance, is linked to DAPRin pathogens such as methicillin‐resistantStaphylococcus aureus. SinceEnterococcus faecalisencodes two paralogs ofmprFand clinical DAPRmutations do not map tomprF, we hypothesized that functional redundancy between the paralogs preventsmprF‐mediated resistance and masks other evolutionary pathways to DAPR. Here, we performed in vitro evolution to DAPRinmprFmutant background. We discovered that the absence ofmprFresults in slowed DAPRevolution and is associated with inactivating mutations inftsH, resulting in the depletion of the chaperone repressor HrcA. We also report thatftsHis essential in the parental, but not in the ΔmprF, strain where FtsH depletion results in growth impairment in the parental strain, a phenotype associated with reduced extracellular acidification and reduced ability for metabolic reduction. This presents FtsH and HrcA as enticing targets for developing anti‐resistance strategies.
Different methods of 3D QRS area calculation from vectorcardiographic X, Y, and Z Leads
Authors: Noheria Amit , Toquica Christian , Mahmood Uzair A. , DeBauge Ashley , Morey Tucker , Harvey Christopher J. 
Published: March 2024

Abstract3DQRSarea is a strong marker for cardiac resynchronization therapy and can be obtained by taking the (i) summation or the (ii) difference of the areas subtended by positive and negative deflections in X, Y, Z vectorcardiographic electrocardiogram (ECG) leads. We correlated both methods with the instantaneous‐absolute‐3D‐voltage‐time‐integral (VTIQRS‐3D). 3DQRSarea consistently underestimated the VTIQRS‐3D, but the summation method was a closer and more reliable approximation. The dissimilarity was less apparent in left bundle branch block (r2 summation .996 vs. difference .972) and biventricular paced ECGs (r2 .996 vs. .957) but was more apparent in normal ECGs (r2 .988 vs. .653).
Status of B‐Lymphocyte Subsets and Their Homing Markers in Patients With Post‐Kala‐AzarDermal Leishmaniasis
Authors: Sengupta Shilpa , Goswami Deep , Chakraborty Bidhan , Chaudhuri Surya Jyati , Ghosh Manab K. , Chatterjee Mitali 
Published: March 2024

ABSTRACTIn visceral leishmaniasis, the Type II helper T cell predominance results in B cell modulation and enhancement of anti‐leishmanial IgG. However, information regarding its dermal sequel, post‐kala‐azar dermal leishmaniasis (PKDL), remains limited. Accordingly, this study aimed to elucidate the B cell‐mediated antibody‐dependent/independent immune profiles of PKDL patients. In the peripheral blood of PKDL patients, immunophenotyping of B cell subsets was performed by flow cytometry and by immunohistochemistry at lesional sites. The functionality of B cells was assessed in terms of skin IgG by immunofluorescence, while the circulating levels of B cell chemoattractants (CCL20, CXCL13, CCL17, CCL22, CCL19, CCL27, CXCL9, CXCL10 and CXCL11) were evaluated by a multiplex assay. In patients with PKDL as compared with healthy controls, there was a significant decrease in pan CD19+B cells. However, within the CD19+B cell population, there was a significantly raised proportion of switched memory B cells (CD19+IgD−CD27+) and plasma cells (CD19+IgD−CD38+CD27+). This was corroborated at lesional sites where a higher expression of CD20+B cells and CD138+plasma cells was evident; they were Ki67 negative and demonstrated a raised IgG. The circulating levels of B cell chemoattractants were raised and correlated positively with lesional CD20+B cells. The increased levels of B cell homing markers possibly accounted for their enhanced presence at the lesional sites. There was a high proportion of plasma cells, which accounted for the increased presence of IgG that possibly facilitated parasite persistence and disease progression.
Do White House Chiefs of Staff “manage up”?
Authors: Beckmann Matthew N. 
Published: March 2024

AbstractThe White House Chief of Staff (COS) has become the modern presidency's organizational lynchpin, the position tasked with helping presidents “faithfully execute the Office of President.” Extending a rich literature about how chiefs manage White House staffers, we consider the other side of the coin: can a COS manage the president? We begin theoretically, sketching three mechanisms—offloading, streamlining, and steering—by which a COS could shape presidents' basic workways. We test resulting hypotheses against original data on presidents' daily work behaviors from John F. Kennedy to George W. Bush—a total spanning 48 years, nine presidencies, and 21 Chiefs of Staff (plus one sustained vacancy). Surprisingly, we find little evidence that Chiefs of Staff affected theduration,density, orcompositionof their president's workday. When it comes to the basic contours of presidential workways, it appears Chiefs of Staff do less “managing up” and more “managing around.”
Curcumin and omega‐3 polyunsaturated fatty acids as bioactive food components with synergistic effects on Alzheimer's disease
Authors: Velasco‐Rodríguez Luz del C. , García Hugo S. , Rascón‐Díaz Martha P. 
Published: March 2024

AbstractCurcumin and omega‐3 polyunsaturated fatty acids (ω‐3 PUFA) are multifunctional compounds which play an important role in Alzheimer's disease (AD) and little has been addressed about the role of these two compounds together in the progression of the disease. There is evidence of the beneficial effect of combined administration of ω‐3 PUFA and other dietary supplements such as vitamins and polyphenols in the prevention of AD, although much remains to be understood about their possible complementary or synergistic activity. Therefore, the objective of this work is to review the research focused on studying the effect and mechanisms of action of curcumin, ω‐3 PUFA, and the combination of these nutraceutical compounds, particularly on AD, and to integrate the possible ways in which these compounds can potentiate their effect. The most important pathophysiologies that manifest in AD will be addressed, in order to have a better understanding of the mechanisms of action through which these bioactive compounds exert a neuroprotective effect.
Knowing what you pay for: Does benefits information increase bond referenda support?
Authors: Ivonchyk Mikhail 
Published: March 2024

AbstractThis article examines the impact of including benefits information on voter support in school bond referenda. It proposes that benefits information can increase voter support and mitigate the negative impact of tax implications. The proposition is tested empirically through a survey experiment, using random assignment and a nationally representative sample. The findings provide causal evidence supporting the proposition, revealing a consistently positive effect of benefits information on voter support across diverse population groups, including homeowners, individuals without children, and supporters of private education. The effect weakens but remains significant even when tax implications are considered. These findings contribute to the existing literature on bond referenda and offer valuable insights for public policy makers aiming to enhance success rates in bond referenda.
Petrologic relationship between lamprophyres, carbonatites, and heavy rare‐earth element enriched breccias at Hicks Dome
Authors: Trela Jarek , Freiburg Jared T. , Gazel Esteban , Nuelle Laurence , Maria Anton H. , Malone David H. , Molinarolo John M. 
Published: March 2024

AbstractNew petrological, geochemical, and P–T modelling results from igneous samples clarify how carbonatite‐lamprophyre magmatism, fluorite and rare earth element (REE) enrichment are petrogenetically related in southern Illinois. P–T modelling reveals that igneous rocks derive from a deep mantle carbonated source, that is consistent with trace element signatures for a fluorine‐rich transition zone origin. Major element systematics suggests liquid‐immiscibility with lamprophyric melts as the origin for Ca‐carbonatites. Heavy REE (HREE) enrichments in Hicks Dome breccias likely formed through preferential partitioning and transport of HREE by brine‐melts, exsolved from a deep carbonatite body. Brine‐melts redistributed HREEs throughout the system along brecciated pathways where they reprecipitated as HREE‐rich phosphate/fluorcarbonate minerals (e.g. xenotime, florencite, synchesite) in host bedrock. The diversity of igneous rocks in southern Illinois highlights the area as an excellent natural laboratory to study carbonated melt petrogenesis and evolution.
Comparison of the Kinematics and Laxity of Total Knee Arthroplasty Bearing Designs Stabilized With Specimen-Specific Virtual Ligaments on a Joint Motion Simulator
Authors: Vakili Samira , Lanting Brent , Getgood Alan , Willing Ryan 
Published: March 2024

Abstract
A variety of total knee arthroplasty (TKA) designs offer increased congruency bearing options, primarily to compensate for a loss of posterior cruciate ligament (PCL) function. However, their efficacy in providing sufficient stability under different circumstances requires further investigation. The preclinical testing of prosthesis components on joint motion simulators is useful for quantifying how design changes affect joint stability. However, this type of testing may not be clinically relevant because surrounding ligaments are either ignored or greatly simplified. This study aimed to assess the kinematics and stability of TKA joints during various motions using condylar-stabilized (CS) bearings without a PCL versus cruciate-retaining (CR) bearings with an intact PCL. TKA prosthetic components were tested on a joint motion simulator while being stabilized with five different sets of specimen-specific virtual ligament envelopes. In comparison to CR knees, CS knees without a PCL exhibited a greater amount of posterior tibial displacement laxity, with a mean increase of 2.7±2.1 mm (p = 0.03). Additionally, significant differences were observed in the anterior–posterior kinematics of the knee joint during activities of daily living (ADL) between the two designs. These results were consistent with previous cadaveric investigations, which indicated that CS knees without a PCL are less resistant to posterior tibial displacement than CR knees with one. This study employing virtual ligaments confirms previous findings that the raised anterior lip of some CS bearings may not completely compensate for the absence of the PCL; however, as both studies used reduced joint contact forces, the contributions of this design feature may be attenuated.
A Histomorphometric and Computational Investigation of the Stabilizing Role of Pectinate Ligaments in the Aqueous Outflow Pathway
Authors: Safa Babak N. , Fraticelli Guzmán Nina Sara , Li Guorong , Stamer W. Daniel , Feola Andrew J. , Ethier C. Ross 
Published: March 2024

Abstract
Murine models are commonly used to study glaucoma, the leading cause of irreversible blindness. Glaucoma is associated with elevated intra-ocular pressure (IOP), which is regulated by the tissues of the aqueous outflow pathway. In particular, pectinate ligaments (PLs) connect the iris and trabecular meshwork (TM) at the anterior chamber angle, with an unknown role in maintenance of the biomechanical stability of the aqueous outflow pathway, thus motivating this study. We conducted histomorphometric analysis and optical coherence tomography-based finite element (FE) modeling on three cohorts of C57BL/6 mice: “young” (2–6 months), “middle-aged” (11–16 months), and “elderly” (25–32 months). We evaluated the age-specific morphology of the outflow pathway tissues. Further, because of the known pressure-dependent Schlemm's canal (SC) narrowing, we assessed the dependence of the SC lumen area on varying IOPs in age-specific FE models over a physiological range of TM/PL stiffness values. We found age-dependent changes in morphology of outflow tissues; notably, the PLs were more developed in older mice compared to younger ones. In addition, FE modeling demonstrated that murine SC patency is highly dependent on the presence of PLs and that increased IOP caused SC collapse only with sufficiently low TM/PL stiffness values. Moreover, the elderly model showed more susceptibility to SC collapse compared to the younger models. In conclusion, our study elucidated the previously unexplored role of PLs in the aqueous outflow pathway, indicating their function in supporting TM and SC under elevated IOP.
Three-Dimensional X-Ray Computed Tomography Image Segmentation and Point Cloud Reconstruction for Internal Defect Identification in Laser Powder Bed Fused Parts
Authors: Xu Boyang , Ouidadi Hasnaa , Handel Nicole Van , Guo Shenghan 
Published: March 2024

Abstract
Defects shape, volume, and orientation all have a direct impact on the mechanical properties of Laser Powder Bed Fused (L-PBF-ed) parts. Therefore, it is necessary to evaluate and analyze the three-dimensional (3D) geometrical characteristics of these defects. X-ray Computed Tomography (XCT) can reveal an object's internal structure by volumetric scanning through its building direction. Point clouds are 3D data that can be extracted from the stack of XCT images taken from a part to perform further analysis. This study presents a novel approach for 3D segmentation and geometrical analysis of L-PBF defect structures from XCT images. The proposed method integrates Voronoi labeling and 3D point cloud reconstruction to reveal individual defect characteristics from the XCT image stack of a part. A case study showed the proposed methodology's effectiveness in identifying and characterizing defect regions in L-PBF-ed Cobalt-Chrome (CoCr) parts.
Efficient Voxel-Based Workpiece Update and Cutter-Workpiece Engagement Determination in Multi-Axis Milling
Authors: Nie Zhengwen , Feng Hsi-Yung 
Published: March 2024

Abstract
This paper presents a new method to efficiently update workpiece and determine cutter-workpiece engagement (CWE) in multi-axis milling simulation based on a uniform voxel modeling space. At each cutter location, a novel algorithm named direct voxel tracing is developed and used to generate a functional cutter surface voxel model to reliably establish the internal space of the milling cutter. The cutter internal space is represented by its voxel boundary with small memory usage. Through the Boolean subtraction between two successive voxel boundaries of the cutter internal space, a minimal voxel deactivation region is attained within which all active workpiece voxels are deactivated (removed) to update the workpiece model. To determine the associated CWE map, a 3D circle voxelization algorithm is employed. By slicing the cutter surface by a sequence of planes perpendicular to and along the cutter axis, CWE can be determined as the sliced 3D circles are voxelized. Quantitative comparisons of the proposed method against existing voxel modeling and vector modeling-based methods have been made. The results have demonstrated much improved computational efficiency of the proposed method in simulating the complex multi-axis milling operations.
Treating Lateral Epicondylopathy With Dry Needling and Exercise: A Case Series
Authors: Hortz Brian V. , Falsone Sue 
Published: March 2024

Context: Lateral epicondylopathy (LE) is a common overuse injury affecting elbow, wrist, and hand function. It is characterized by weakness and pain in the muscles and tendons of the forearm responsible for the extension of your wrist and fingers. Trigger point dry needling is a technique reported to be beneficial in managing pain and dysfunction after LE diagnosis. LE is also commonly treated with conservative treatment, such as joint and soft tissue mobilization, self-care home programs, and anti-inflammatory use. We explored a different dry needling approach consisting of in situ dry needling with electric stimulation combined with targeted therapeutic exercise to treat LE in 3 cases. Case Presentation: Three patients were referred for dry needling once a week for 6 weeks and home-based exercise therapy for LE. They were clinically evaluated using grip strength, a visual analog scale to assess pain, and Patient-Rated Tennis Elbow Evaluation Test scores. These were measured at 4 time points (weeks 0, 2, 4, and 6). Management and Outcomes: The dry needling intervention incorporated 8 locations in the upper-extremity with 2 electric stimulation channels. The patients had reduced pain as measured by a visual analog scale, increased function as measured by the Patient-Rated Tennis Elbow Evaluation Test, and increased grip strength over 6 weeks. Conclusions: This case series illustrates the use of dry needling and a home exercise program to provide a favorable outcome in a patient with LE. Patients had an 80% to 100% reduction in pain and similar improvements in function that were significantly beyond the minimum clinically important difference. This dry needling approach is a safe and effective treatment of LE in the short term.