bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sospecha de delirium y posibles factores relacionados en el adulto mayor hospitalizado
Authors: Fajardo Ramos Elizabeth , Gómez Tovar Luz Omaira , Henao-Castaño Ángela María 
Published: April 2024

Objetivo: describir la sospecha de delirium en adultos mayores hospitalizados en medicina interna y sus posibles factores relacionados.
Materiales y método: estudio correlacional de corte transversal y muestreo por conveniencia, con 49 adultos mayores de 70 años hospitalizados en medicina interna que aceptaron participar de forma voluntaria. Se aplicó la Escala de Detección de Delirium por Enfermería (Nu-DESC), la cual mide la sospecha de delirium, y se empleó análisis descriptivo y bivariado.
Resultados: la prevalencia de sospecha de delirium en los pacientes del estudio fue de 20,4 %. La edad fue significativamente menor en los pacientes que no presentaron delirium en comparación con aquellos que mostraron sospecha (73 vs. 82 años, respectivamente, p = 0,05). Otras variables que evidenciaron un comportamiento similar son el número de comorbilidades (1 sin delirium vs. 2 sospecha, p = 0,037), haber padecido delirium al menos una vez antes de la actual hospitalización (1 sin delirium vs. 6 sospecha, p = 0,000) y no reportar antecedentes psicoactivos (17 sin delirium vs. 3 sospecha p = 0,009). El análisis bivariado evidenció una posible asociación significativa entre el delirium y los antecedentes de diabetes (OR 6,8; IC 95 % 1,43-32,19 [p = 0,020]), el consumo de alcohol (OR 5,2; IC 95 % 1,15-23,85 [p = 0,029]) y antecedentes de delirium en hospitalización previa (OR 6,3; IC 95 % 1,02-38,9 [p = 0,000]).
Conclusiones: el delirium es un problema que continúa impactando a los adultos, particularmente a los adultos mayores, quienes por los factores fisiológicos propios de la edad son más vulnerables a padecer este evento.
Inhibitory activity and molecular mechanism of the total alkaloids of Dendrobium officinale Kimura et Migo against cholesterol esterase
Authors: Feng Y. , Li G.X. , Hu T.T. , Deng W.B. , Yang H.L. , Wu X.T. , Zheng X.J. 
Published: April 2024

AbstractThis study aimed to explore the inhibitory effect and mechanism of the total alkaloids of Dendrobium officinale Kimura et Migo (DENA) against cholesterol esterase (CE). DENA was characterised by SEM, 1H NMR, and X-ray diffraction (XRD). The inhibitory effect and mechanism of DENA against CE were investigated through fluorescence chromatography, circular dichroism, and molecular docking. DENA inhibited CE activity (IC50 = 1.08 ± 0.09 mg mL−1), characterised by a non-competitive inhibition mechanism. Furthermore, DENA induced a fluorescence quenching in CE, causing a blue shift in the λmax. This coincided with a transition in the secondary structure of CE from a layered to a helical structure by circular dichroism, indicating a significant reduction in its stability. Moreover, molecular docking confirmed that DENA binds to amino acid residues in the enzyme through hydrogen bonds and hydrophobic interactions, leading to structural changes and reduced enzyme activity. These results suggest DENA has the potential to lower blood lipid levels by inhibiting CE activity.
Accessing the influence of perceived brand authenticity and value co-creation on brand loyalty of China’s insurgent brands: The mediating role of psychological ownership
Authors: Ma Hongru , Chelliah Shankar 
Published: April 2024

This study is motivated by the need to thoroughly investigate the impact of perceived brand authenticity and value co-creation on brand loyalty within the context of China's insurgent brands. In particular, the study uses the psychological ownership theory to examine the mediating role of psychological ownership. The dynamic nature of the Chinese market underscores the significance of understanding how these factors influence consumer behavior and brand loyalty in this specific context. SmartPLS 3.0 software was used to conduct a thorough analysis of a substantial dataset consisting of 368 completed survey responses which were collected through a robust technique that included online survey questionnaires and purposive sampling. The findings demonstrate positive associations between perceived brand authenticity, value co-creation, psychological ownership and brand loyalty with psychological ownership serving as a mediating mechanism. This study underscores their role in propelling brand loyalty, thereby contributing to the growth and success of China’s insurgent brands emphasizing the importance of marketing strategies that prioritize authenticity, value co-creation and psychological ownership. Additionally, this research extends the application of psychological ownership theory to the distinctive landscape of China’s insurgent brands addressing a void in empirical research. The insights derived from this study provide valuable guidance for insurgent brands looking to foster brand loyalty in this specific context laying the groundwork for strategic marketing approaches in the dynamic Chinese market.
Agropolitana: Countryside and Urban Sprawl in the Veneto Region (Italy)
Authors: Ferrario Viviana 
Published: April 2024

In the Veneto central plane, historically shaped by agriculture, the countryside is being taken over by a particular form of urban sprawl, called città diffusa (dispersed city), where cities, villages, single houses and industries live alongside agriculture. This phenomenon is generally analyzed mainly as a typical urban/rural conflict, and the sprawl gets criticized as a countryside destroyer.
By observing some paradoxical situations in the città diffusa in Veneto, the contrary is apparent – urban sprawl seems to have been rather a conservation factor for the ecological and cultural richness of the agricultural space. Agricultural space itself plays an important multifunctional role in this territory. If seen from this point of view, dispersed urbanization in the Veneto region can be seen as a sort of prototype of a new contemporary form - neither urban nor rural – of cultural landscape, where farming spaces can have a public role strictly linked to the urban population's needs. Can this character be preserved through the metropolization process now envisaged by regional policy and planning, and already happening? Can the “Agropolitana” concept introduced by the new Regional Spatial Plan help to imagine and obtain a resilient metropolis, while maintaining a strong agricultural layer inside it?
Pengaruh Pengembangan Karir dan Kepuasan Kerja Terhadap Komitmen Organisasi PT. X
Authors: Ayu Yulfika Dewi  , Sholikhah  , Suherman  
Published: April 2024

ABSTRACT
The purpose of this research are : To find out 1) the effect of career development on organizational commitment at PT X, 2) the effect of job satisfaction on organizational commitment at PT X and 3) the simultaneously effect of career development and job satisfaction on organizational commitment at PT X,. This study used the Statistical Package for The Social Sciences (SPSS) method to analyze the data. The research model used in this study uses descriptive and explanatory. This research was conducted on 121 employees of PT X with probability sampling technique. The data collection technique used survey method, namely distributing questionnaires which were then processed using the SPSS 23.0 program. The results obtained from the regression indicate that there is a significant positive effect between career development on organizational commitment, and the significant influence between job satisfaction on organizational commitment and, career development and job satisfaction together have a significant influence on organizational commitment at PT X

Keywords: career development, job satisfaction, organizational commitment

ABSTRAK
Tujuan penelitian ini adalah: Untuk mengetahui 1) pengaruh pengembangan karir terhadap komitmen organisasi pada PT X, 2) pengaruh kepuasan kerja terhadap komitmen organisasi pada PT X dan 3) pengaruh secara simultan dari pengembangan karir dan kepuasan kerja terhadap komitmen organisasi pada PT X,. Penelitian ini dengan metode Statistic Package for The Social Sciences (SPSS) untuk menganalisis data. Model penelitian yang dilakukan dalam penelitian ini menggunakan analisis deskriptif dan explanatory. Penelitian ini dilakukan terhadap 121 karyawan PT X dengan teknik nonprobability sampling. Teknik pengumpulan data menggunakan metode survei yaitu menyebarkan kuisioner yang kemudian diolah dengan progam SPSS 23.0. Hasil yang didapatkan dari regresi menunjukan bahwa terdapat pengaruh yang positif signifikan antara pengembangan karir terhadap komitmen organisasi dan pengaruh dan signifikan antara kepuasan kerja terhadap komitmen organisasi dan pengembangan karir dan kepuasan kerja bersama-sama memiliki pengaruh signifikan terhadap komitmen organisasi pada PT X

Kata kunci : Pengembangan Karir, Kepuasan Kerja, Komitmen Organisasi
Pengaruh Pengembangan Karir dan Motivasi Kerja Terhadap Organizational Citizenship Behavior di Karyawan PT Sharp Semiconductor Indonesia
Authors: Senoaji Satrio , Susita Dewi , Wiradendi Wolor Christian 
Published: April 2024

The purpose of this research are as follows: 1) To find out the description or description of career development, work motivation, compensation, Organizational Citizenship Behavior (OCB) on employees of PT Sharp Semiconductor Indonesia. 2) To determine the effect of career development on Organizational Citizenship Behavior (OCB) on employees of PT Sharp Semiconductor Indonesia. 3) To determine the effect of work motivation on Organizational Citizenship Behavior (OCB) on employees of PT Sharp Semiconductor Indonesia. 4) To determine the effect of career development and work motivation simultaneously on Organizational Citizenship Behavior (OCB) on employees of PT Sharp Semiconductor Indonesia. To determine the effect of career development and work motivation on Organizational Citizenship Behavior at PT. Sharp Semiconductor Indonesia, this research was conducted on 452 employees at PT. Sharp Semiconductor Indonesia, using a sample of 82 employees. The study uses a quantitative approach using causal explanatory research methods that aim to explain how a certain variable can affect or cause changes to other variables. The data collection technique used in this study was through a survey method by distributing questionnaires, which then the data obtained would be processed using the SmartPLS version 3 software.
Keywords: Career Development, Work Motivation, Organizational Citizenship Behaviour
Tujuan dari penelitian ini adalah sebagai berikut : 1) Untuk mengetahui gambaran atau deskripsi dari pengembangan karir, motivasi kerja, kompensasi, Organizational Citizenship Behavior (OCB) pada karyawan PT Sharp Semiconductor Indonesia. 2) Untuk mengetahui pengaruh pengembangan karir terhadap Organizational Citizenship Behavior (OCB) pada karyawan PT Sharp Semiconductor Indonesia. 3) Untuk mengetahui pengaruh motivasi kerja terhadap Organizational Citizenship Behavior (OCB) pada karyawan PT Sharp Semiconductor Indonesia. 4) Untuk mengetahui pengaruh pengembangan karir dan motivasi kerja secara simultan terhadap Organizational Citizenship Behavior (OCB) pada karyawan PT Sharp Semiconductor Indonesia. Untuk mengetahui pengaruh Pengembangan karir dan Motivasi kerja terhadap Organizational Citizenship Behavior pada PT. Sharp Semiconductor Indonesia, penelitian ini dilakukan kepada 452 karyawan pada PT. Sharp Semiconductor Indonesia, dengan penggunaan sampel sebanyak 82 karyawan. Penelitian menggunakan pendekatan kuantitatif dengan menggunakan metode riset eksplanatoris kausal yang bertujuan untuk menjelaskan bagaimana suatu variable tertentu bisa mempengaruhi atau menyebabkan perubahan kepada variable – variable lainnya. Teknik pengumpulan data yang digunakan dalam penelitian ini melalui metode survei dengan penyebaran kuesioner, yang kemudian data yang didapatkan akan diolah menggunakan peranti lunak SmartPLS versi 3.
Kata kunci : Pengembangan Karir, Motivasi Kerja, Organizational Citizenship Behaviour
Pesticide contamination patterns in Montagu’s harrier (Circus pygargus) chicks
Authors: Fuentes Elva , Moreau Jérôme , Rodrigues Anaïs , Millet Maurice , Bretagnolle Vincent , Monceau Karine 
Published: April 2024

Abstract

Biomonitoring of persistent pesticides in birds of prey has been carried out for decades, but few studies have investigated their relevance for the monitoring of non-persistent pesticides. Herein, we determined the contamination patterns of multiple pesticides in Montagu’s harrier (Circus pygargus) chicks in an intensive farming area of southwestern France. Blood samples from 55 chicks belonging to 22 nests in 2021 were assessed for 104 compounds (herbicides, fungicides, insecticides, safeners and synergists). All chicks had at least one herbicide in their blood, and half had at least two compounds. The 28 compounds detected comprised 10 herbicides, 12 fungicides, 5 insecticides and 1 synergist. Mixtures in blood were predominantly composed of herbicides, and six chicks presented a mixture of the three pesticide classes. The most prevalent compounds were sulcotrione (96% of chicks), tebutam (44%) and chloridazon (31%), of which the latter two had been banned in France for 19 and 3 years, respectively, at the time of sampling. Most compounds are considered non-acutely toxic but sulcotrione is potentially carcinogenic, mutagenic and reprotoxic, raising questions about the effects on the health of nestlings. Biomonitoring of multiple pesticides through Montagu’s harrier chicks in agroecosystems is clearly relevant because it reflects the general pattern of agricultural pesticide use in the study area. It also raises questions about exposure pathways in chicks, and further investigations are needed to disentangle the roles of dietary routes and maternal transfer for the established pesticide contamination patterns.
A novel Golgi related genes based correlation prognostic index can better predict the prognosis of glioma and responses to immunotherapy
Authors: Zhao Beichuan , Xuan Ruoheng , Yang Guitao , Hu Tianyu , Chen Yihong , Cai Lingshan , Hu Bin , Ling Gengqiang , Xia Zhibo 
Published: April 2024

Abstract

Background
The Golgi apparatus (GA) serves as the center of protein and lipid synthesis and modification within cells, playing a crucial role in regulating diverse cellular processes as a signaling hub. Dysregulation of GA function can give rise to a range of pathological conditions, including tumors. Notably, mutations in Golgi-associated genes (GARGs) are frequently observed in various tumors, and these mutations have been implicated in promoting tumor metastasis. However, the precise relationship between GARGs and glioma, a type of brain tumor, remains poorly understood. Therefore, the objective of this investigation was to assess the prognostic significance of GARGs in glioma and evaluate their impact on the immune microenvironment.
Methods
The expression of GARGs was obtained from the TCGA and CGGA databases, encompassing a total of 1564 glioma samples (598 from TCGA and 966 from CGGA). Subsequently, a risk prediction model was constructed using LASSO regression and Cox analysis, and its efficacy was assessed. Additionally, qRT-PCR was employed to validate the expression of GARGs in relation to glioma prognosis. Furthermore, the association between GARGs and immunity, mutation, and drug resistance was investigated.
Results
A selection of GARGs (SPRY1, CHST6, B4GALNT1, CTSL, ADCY3, GNL1, KIF20A, CHP1, RPS6, CLEC18C) were selected through differential expression analysis and Cox analysis, which were subsequently incorporated into the risk model. This model demonstrated favorable predictive efficiency, as evidenced by the area under the curve (AUC) values of 0.877, 0.943, and 0.900 for 1, 3, and 5-year predictions, respectively. Furthermore, the risk model exhibited a significant association with the tumor immune microenvironment and mutation status, as well as a diminished sensitivity to chemotherapy drugs. qRT-PCR analysis confirmed the up-regulation or down-regulation of the aforementioned genes in glioma.
Conclusion
The utilization of GARGs in our constructed model exhibits a high level of accuracy in prognosticating glioma and offers promising avenues for the development of therapeutic interventions targeting glioma.
Isolation, Characterization, and Herbicidal Activity of Streptomyces spp. from Diseased Potato Scab Tubers
Authors: HUANG Zhong-di , SHI Shu-ping , ZHANG Yi , YIN Cai-ping , ZHANG Shu-xiang , Zhang Yinglao 
Published: April 2024

Abstract
Background
A highly effective and environmentally friendly method of controlling weeds is biological herbicides, which typically constitute of naturally secondary metabolites, such as bioherbicidal metabolites produced by Streptomyces sp. However, the isolation of phytotoxic compounds from pathogenic Streptomyces has not been fully studied.
Results
Here, a total of 50 strains of Streptomyces genera were isolated from the potato tubers with typical common scab (CS) symptoms using the culture-dependent method. The radish seedling test indicated that 32 fermentation broths of potato common scab-associated Streptomyces could produce phytotoxic metabolites that affect the normal growth of radish seedlings’ radicles. Of note, two potential new pathogens (NKY-4 and L7-2) of potato scab were discovered by combining the methods of radish seedlings, potato tuber slices, and PCR detection of pathogenic genes txtAB. Moreover, the phytotoxic test demonstrated that the fermentation broths of 31 strains exhibited phytotoxic activities against at least one of the tested weeds (Echinochloa crusgalli, Digitaria sanguinalis, and Abutilon theophrastis). Furthermore, one novel metabolite and three known compounds, including new N-(2,5-dihydroxyphenyl)-3-acetamide-4-hydroxybenzamide (1), thaxtomin A (2), nicotinic acid (3) and pyrrole-2-carboxylic acid (4) were isolated from S. bottropensis (AMCC400023). Among them, compound 2 exhibited strong phytotoxic activity against E. crusgalli, D. sanguinalis, and A. theophrast with IC50 values of 0.99, 0.78, and 1.95 µg/mL, respectively, which was comparable to those of the positive control 2,4-D.
Conclusions
Based on the results of these findings, phytotoxic metabolites from the potato scab pathogen may be one of the effective ways to develop new biological herbicides.
Ultrasound guided pediatric caudal dose: A prospective, randomized, observer-blinded clinical trial.
Authors: Syal Kartik , Chandel Ankita , Kanwar Manjit Singh 
Published: April 2024

Abstract

Background: The drug volume to be used in caudal in pediatric patients has remained an unmet issue since long. We determined the minimum drug volume required to reach T10 level in pediatric patients using ultrasonography and compared it with the already established volume by Armitage formula.
Aim: To determine the minimum effective caudal local anesthetic dose using ultrasound guidance.
Methods: Study was performed at two centres and at each centre, 50 pediatric patients (Total 100 patients), aged 1 to 3 years, undergoing below umbilical surgeries were included and randomised into two groups of 25 each (Total 50) to receive ultrasound guided drug volume vs Armitage formula based volume. The volume required to reach T10 level was assessed with ultrasound in one group. Also, maximum height achieved, cutaneous level achieved after 15 minutes and parental satisfaction scores were noted.
Results: The mean drug volume required to reach T10 level in Group U was 0.755 ± 0.053 ml/kg with a P value <0.001. (Compared to the drug volume of 1 ml/kg using one sample t test). The highest level achieved in both groups were calculated as the mode value of T8 and T7 in Group U and Group A respectively. The highest cutaneous level achieved after 15 minutes was also calculated as the mode value of T4 in both groups. Satisfaction scores were comparable in both groups.
Conclusion: A volume of 0.7 ml/kg of local anaesthetic in pediatric caudal block is sufficient to achieve a target of T10 level for infraumblical surgeries.
Comparison of MRI-guided Ultrasound Fusion Biopsy and Cognitive Targeted Biopsy in the Diagnosis of Clinically Significant Prostate Cancer: Lesion Size Matters
Authors: Shao I-Hung , Liao Fan-Ting , Chang Chun-Bi , Chang Ying-Hsu , Wang Li-Jen , Huang Liang-Kang , Kan Hung-Cheng , Lin Po-Hung , Yu Kai-Jie , Chuang Cheng-Keng , Wu Chun-Te , Pang See-Tong 
Published: April 2024

Abstract

Purpose MRI-guided targeted biopsy (MRGB) was recommended as part of biopsy paradigm of prostate cancers by current guidelines. This study aimed to analyze the diagnostic efficacy of MRGB and systemic biopsy (SB), and to compare diagnostic capabilities within subgroups of MRGB: MRI-cognitive biopsy (MRCB) and MRI-fusion biopsy (MRFB).Materials and Methods We retrospectively enrolled patients who underwent MRGB for suspicious malignant lesion(s) identified on MRI in a single tertiary center. An mpMRI was performed prior to biopsy and reviewed by an experienced radiologist specialized in prostate cancer. Per-person results of MRGB and each concomitant SB were analyzed as independent biopsies for its positive biopsy rate and positive core percentage. Per-lesion results of MRFB and MRCB were compared for the detection rate. Variables of interest were analyzed with t-test, chi-squared test, and logistic regression analysis. Statistical analyses were performed with SPSS software version 23.Results Total of 74 patients fulfilled the inclusion criteria and were enrolled. MRFB had higher PCa detection rate comparing to both MRCB and SB (56.1%, 30.3%, and 33.9% respectively, p value = 0.036); csPCa detection rate was also significantly higher in MRFB group (43.9%, 24.2%, and 16.9% in each group respectively, p value = 0.011). In per-lesion analysis, MRCB and MRFB had no significant difference in PCa and csPCa detection rate (41.0% vs. 26.2% and 29.5% vs. 16.7% respectively, p value = 0.090 and 0.103). In the lesion ≦ 1.3 cm group, MRFB could achieve higher PCa detection rate, comparing to MRCB (36.4% vs. 14.3%, p value = 0.047); there were also higher positive rates for PCa and csPCa per biopsied cores (22.1% vs. 6.8% and 15.6% vs. 2.7%, p value = 0.029 and 0.028, respectively). Further logistic regression of multi-variate analysis in subgroup of lesion ≦ 1.3 cm revealed that PIRADS score and biopsy method were significant predictors of positive biopsy result for PCa (p value = 0.045 and 0.026, respectively) and for csPCa (p value = 0.043 and 0.025, respectively).Conclusion In patients receiving trans-perineal prostate biopsy, MRFB had higher cancer detection rate than MRCB and SB. In per lesion comparison, MRFB and MRCB had similar diagnostic accuracy. However, in lesions with diameter less than 1.3 cm, MRFB can provided better diagnose value for PCa and csPCa than MRCB.