bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Design and control of a mobile robot following the desired Trajectory using an adaptive sliding mode approach
Authors: LIU YONGQIU , Zhong Shaohui , MUSTAFA KAINAT , Aslam Sheraz , Daraz Amil 
Published: March 2024

Abstract
The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Spatio-temporal dynamics monitoring of surface water bodies in Nhat Le River Basin, Vietnam, by Google Earth Engine
Authors: Minh Vu Anh , Quang Dinh Nhat , Tinh Nguyen Xuan , Ribbe Lars 
Published: March 2024

Abstract

Consistent monitoring of surface water dynamics is essential for water resources, flood risk management, and addressing the challenges posed by climate change, urbanization. Nhat Le River Basin witnesses significant and noticeable dynamics in surface water on a yearly basis due to water-related disasters like floods and droughts. This article presents the first comprehensive study to systematically map and analyse the long-term (2016–2022) spatiotemporal dynamics of surface water in the Nhat Le River Basin of Vietnam, utilizing Sentinel-1 data. The results reveal that the optimal threshold for separating water from non-water pixels is −19 dB, with an overall accuracy of 0.93–0.94 and a Kappa coefficient of 0.77–0.82. Through quantitative analysis, the study characterizes seasonal and interannual variations in the surface water extent, contributing to an enhanced understanding of flood patterns and associated risks in a data-scarce region. Our analysis reveals the Kien Giang river delta as the most flooding-vulnerable sub-region, underscoring the importance of targeted risk management and adaptation planning in this area. A Google Earth Engine Tool is developed for automatic detecting, monitoring, and accessing the spatiotemporal dynamics of surface water in Nhat Le River Basin over the period 2016–2022 and is available on GitHub (https://github.com/MinhVu25/Surface_Water_Dynamics_2023).
Magnetic MoS2/Fe3O4 composite as an effective activator of persulfate for the degradation of tetracycline: performance, activation mechanisms and degradation pathways
Authors: Zhang Lanhe , Zhang Qi , Chen Tengyue , Wang Changyao , Xiao Chuan , Guo Jingbo , Pang Xiangrui , Liu Shuhua 
Published: March 2024

ABSTRACT

The activated persulfate (PS) process could produce sulfate radical (SO4·-) and rapidly degrade organic pollutants. The application of Fe3O4 as a promising PS activator was limited due to the rapid conversion of Fe2+ to Fe3+ on its surface. Mo4+ on MoS2 surface could be used as a reducing site to convert Fe3+ to Fe2+, but the separation and recovery of MoS2 was complex. In this study, MoS2/Fe3O4 was prepared to accelerate the Fe3+/Fe2+ cycle on Fe3O4 surface and achieved efficient separation of MoS2. The results showed that MoS2/Fe3O4 was more effective for PS activation compared to Fe3O4 or MoS2, with a removal efficiency of 91.8% for 20 mg·L−1 tetracycline (TC) solution under the optimal conditions. Fe2+ and Mo4+ on MoS2/Fe3O4 surface acted as active sites for PS activation with the generation of SO4•−, •OH, •O2−, and 1O2. Mo4+ acted as an electron donor to promote the Fe3+/Fe2+ cycling and thus improved the PS activation capability of MoS2/Fe3O4. The degradation pathways of TC were inferred as hydroxylation, ketylation of dimethylamino group and C-N bond breaking. This study provided a promising activated persulfate-based advanced oxidation process for the efficient degradation of TC by employing MoS2/Fe3O4 as an effective activator.
HAND2-AS1 Promotes Ferroptosis to Reverse Lenvatinib Resistance in Hepatocellular Carcinoma by TLR4/NOX2/DUOX2 Axis
Authors: Song Zheng , Zhang Yu , Luo Wei , Sun Chao , Lv Caihong , Wang Sihao , He Quanwei , Xu Ran , Bai Zhaofang , Chang Xiujuan , Yang Yongping 
Published: March 2024

Introduction:
Lenvatinib resistance causes less than 40% of the objective response
rate. Therefore, it is urgent to explore new therapeutic targets to reverse the lenvatinib resistance
for HCC. HAND2-AS1 is a critical tumor suppressor gene in various cancers.

Methods:
Here, we investigated the role of HAND2-AS1 in the molecular mechanism of lenvatinib
resistance in HCC. It was found that HAND2-AS1 was lowly expressed in the HepG2 lenvatinib
resistance (HepG2-LR) cells and HCC tissues and associated with progression-free intervals
via TCGA. Overexpression of HAND2-AS1 (OE-HAND2-AS1) decreased the IC50 of lenvatinib
in HepG2-LR cells to reverse lenvatinib resistance. Moreover, OE-HAND2-AS1 induced intracellular
concentrations of malondialdehyde (MDA) and lipid ROS and decreased the ratio of glutathione
to glutathione disulfide (GSH/GSSG) to promote ferroptosis.

Results:
A xenograft model in which nude mice were injected with OE-HAND2-AS1 HepG2-LR
cells confirmed that OE-HAND2-AS1 could reverse lenvatinib resistance and decrease tumor formation
in vivo. HAND2-AS1 promoted the expression of ferroptosis-related genes (TLR4, NOX2,
and DUOX2) and promoted ferroptosis to reverse lenvatinib resistance by increasing TLR4/
NOX2/DUOX2 via competing endogenous miR-219a-1-3p in HCC cells. Besides, patients
with a low HAND2-AS1 level had early recurrence after resection.

Conclusion:
HAND2-AS1 promotes ferroptosis in HCC cells and reverses lenvatinib resistance
by regulating TLR4/NOX2/DUOX2 axis. It suggested that HAND2-AS1 may be a potential therapeutic
target and an indicator of early recurrence for HCC.
Magnetic Resonance Images Segmentation of Multifidus based on Dense-unet
and Superpixel
Authors: Xu Rui , Guo Xin , Wang Zimin , Guan Tingqiang , Zhou Yue 
Published: March 2024

Background::
Lumbar disc herniation (LDH) is a common clinical condition causing lower back and leg pain. Accurate segmentation of the lumbar discs is
crucial for assessing and diagnosing LDH. Magnetic resonance imaging (MRI) can reveal the condition of articular cartilage. However, manual
segmentation of MRI images is burdensome for physicians and needs to be more efficient.

Objective::
In this study, we propose a method that combines UNet and superpixel segmentation to address the problem of loss of detailed information in the
feature extraction phase, leading to poor segmentation results at object edges. The aim is to provide a reproducible solution for diagnosing patients
with lumbar disc herniation.

Methods::
We suggest using the network structure of UNet. Firstly, dense blocks are inserted into the UNet network, and training is performed using the
Swish activation function. The Dense-UNet model extracts semantic features from the images and obtains rough semantic segmentation results.
Then, an adaptive-scale superpixel segmentation algorithm is applied to segment the input images into superpixel images. Finally, high-level
abstract semantic features are fused with the detailed information of the superpixels to obtain edge-optimized semantic segmentation results.

Results::
Evaluation of a private dataset of multifidus muscles in magnetic resonance images demonstrates that compared to other segmentation algorithms,
this algorithm exhibits better semantic segmentation performance in detailed areas such as object edges. Compared to UNet, it achieves a 9.5%
improvement in the Dice Similarity Coefficient (DSC) and an 11.3% improvement in the Jaccard Index (JAC).

Conclusion::
The experimental results indicate that this algorithm improves segmentation performance while reducing computational complexity.
Protective Effect of Natural Plant Products against the Rotenone-induced
Neurotoxicity
Authors: Subhan Iqra , Siddique Yasir Hasan 
Published: March 2024

Abstract:
Neurodegenerative diseases are a group of disorders characterized by the progressive
degeneration of the neurons and function of the nervous system. These diseases typically result
in a decline in cognitive, motor, or sensory functions and often lead to disability in many cases.
Rotenone is a naturally occurring compound isolated from the roots and stems of several plants
that induced neurotoxicity by inhibiting the mitochondrial complex I resulting in the generation
of reactive oxygen species (ROS) and induced the ROS generation. Natural plant products can
play an important role in the treatment of neurodegenerative diseases. This review focusses on
the therapeutic potential of natural products and their bioavailability to exert neuroprotective
effects against the neurodegenerative diseases.
Recent Stressful Experiences and Electronic Nicotine Product Use
Among Young Adults
Authors: Gherghe Anda , Fahey Kalina M.L. , Cservenka Anita 
Published: March 2024

Background and Objective:
The goal of the current study was to examine how
specific recent stressors are related to electronic nicotine product use among young adults.
Despite increases in electronic nicotine product use among adults, stressors shaping the use
of these products remain largely unknown. The current study examined the types and average
severity of stressors endorsed between young adults with past 30-day electronic nicotine
product use and young adults with no lifetime use, as well as the association between
frequency of recent electronic nicotine product use and average severity of stressors.

Methods:
175 current electronic nicotine product users and 333 lifetime abstainers of electronic
nicotine products and cigarettes reported recent stressful experiences that occurred
in the past six months, as well as lifetime and past 30-day substance use. Chi-square, independent
samples t-test, and regression analyses were performed.

Results:
There were no significant group differences in the primary type of stressor experienced
(p = 0.320) or average stress of the three recent stressful experiences reported (p =
0.246). There was no significant relationship between electronic nicotine product use and
average stress of the three recent stressful experiences, controlling for demographic and
substance use covariates (p = 0.150). Both current electronic nicotine product users and
lifetime abstainers endorsed school, family, and romantic relationship stressors most frequently
as their top stressors.

Conclusion:
To our knowledge, this is the first study to examine group differences in specific
stressor categories and perceived stress between current electronic nicotine product
users and lifetime abstainers of these products. Given the novel assessment of stressor
types, the current study provides a critical starting point for research on this timely topic.
In addition, due to the high overlap between stress and nicotine use, future studies should
investigate different populations of electronic nicotine product users and other methods to
assess stressful experiences.
Exploring the Design of Upper Limb Strength Training Through High-Intensity Interval Training Combined With Exergaming: Usability Study
Authors: Lin Shu-Cheng , Lee Jing-Yu , Yang Yong , Fang Chu-Chun , Fang Hsiao-Lin , Hou Tien-Hung 
Published: March 2024

Abstract

Background
High-intensity interval training (HIIT) has become a popular exercise strategy in modern society, with the Tabata training method being the most popular. In the past, these training methods were mostly done without equipment, but incorporating exergaming into the training may provide a new option for muscle training.

Objectives
The aim of this study was to explore the differences in upper limb muscle activation using an HIIT program combined with exergaming.

Methods
A total of 15 healthy male participants were recruited for the study, and the differences in muscle activation were compared between push-ups and exergaming (Nintendo Switch Ring Fit Adventure with the Ring-Con accessory) during HIIT. Prior to the tests, participants underwent pretests, including maximal voluntary contractions of various muscle groups, maximal push-up tests, and maximal movement tests using the exergaming device. The push-up and exergaming tests were conducted on separate days to avoid interference, with a warm-up period of 5 minutes on a treadmill before testing. Muscle activation in the lateral and anterior portions of the deltoid muscle, the sternal and clavicular heads of the pectoralis major muscle, and the latissimus dorsi muscle were measured during the maximal voluntary contractions and single-round tests for each exercise mode. A repeated measures ANOVA was used to assess the variations in muscle activation observed across the 2 distinct modes of exercise, specifically push-ups and exergaming.

Results
In exergaming, the number of repetitions for push-ups was significantly fewer than for single-site exercises across both exhaustive (mean 23.13, SD 6.36 vs mean 55.67, SD 17.83; P=.001; effect size [ES]: 2.43) and single-round (mean 21.93, SD 7.67 vs mean 92.40, SD 20.47; P=.001; ES: 4.56) training. Heart rate differences were not significant (all P>.05), yet exergaming led to better muscle activation in specific muscle groups, particularly the right anterior deltoid (mean 48.00%, SD 7.66% vs mean 32.84%, SD 10.27%; P=.001; ES: 1.67) and right pectoralis major (sternal head: mean 38.99%, SD 9.98% vs mean 26.90%, SD 12.97%; P=.001; ES: 1.04; clavicular head: mean 43.54%, SD 9.59% vs mean 30.09%, SD 11.59%; P=.002; ES: 1.26) during exhaustive training. In single-round training, similar patterns were observed with the anterior deltoid (mean 51.37%, SD 11.76% vs mean 35.47%, SD 12.72%; P=.002; ES: 1.30) and pectoralis major (sternal head: mean 53.27%, SD 10.79% vs mean 31.56%, SD 16.92%; P=.001; ES: 1.53; clavicular head: mean 53.75%, SD 13.01% vs mean 37.95%, SD 14.67%; P=.006; ES: 1.14). These results suggest that exergaming may be more effective for targeted muscle activation.

Conclusions
In conclusion, HIIT can increase muscle activation in the upper extremities and can be incorporated into exergaming strategies to provide a fun and engaging way to exercise.
Evaluación de las propiedades hidro-litológicas de las unidades geológicas y depósitos sedimentarios, al sureste del municipio de Villanueva- La Guajira (Colombia), para la determinación del potencial acuífero
Authors: Anteliz-Galán Yuleineth Giseth , Holguín-Duran José Valdemar , Mercado-Zabaleta Diana Carolina , Rojas-Martinez Elías Ernesto , Manco-Jaraba Dino Carmelo 
Published: March 2024

Esta investigación se enfoca a la evaluación del potencial acuífero de las unidades geológicas y depósitos sedimentarios aflorantes al sureste del municipio de Villanueva, La Guajira, a partir de ensayos de porosidad por método gravimétrico y permeabilidad al gas, permitiendo la determinación de la baja capacidad de las rocas tipo packstone del Grupo Cogollo y limolita de la Formación La Quinta para captar y transmitir agua; además, se realizaron ensayos de permeabilidad al líquido y porosidad por método gravimétrico a los sedimentos Cuaternarios determinándose un coeficiente de permeabilidad moderado a alto apoyado con análisis de granulometría para su clasificación como sedimentos areno-gravosos, asimismo, se implementó el método de Lefranc en seis puntos escogidos de manera aleatoria arrojando un coeficiente de permeabilidad alto.
Las unidades litológicas encontradas en el área se encuentran afectadas por estructuras de carácter regional, como el Sinclinal El Espíritu que constituye una estructura potencial para almacenamiento y transmisión de agua; la Formación La Quinta es afectada por la falla Cerrejón que actúa como barreras limitantes de posibles acuíferos en la zona. Se infiere que el Grupo Cogollo tiene potencial de acuífero por porosidad secundaria al encontrarse altamente fracturada y presentar estructuras de microporosidad por disolución y karstificación, los depósitos Cuaternario exhiben coeficientes de permeabilidad de moderados a alto, mientras que la Formación La Quinta no muestra potencial de acuífero promisorio debido a su compactación, silicificación y bajo coeficiente de permeabilidad.
La terrazza inferiore del complesso monumentale del vallone orientale (SAS 3/30). La campagna di scavo 2022: nuovi dati e problemi aperti
Authors: Michelini Chiara , Parra Maria Cecilia 
Published: March 2024

Si presentano i risultati degli scavi 2022 nella terrazza inferiore del Thesmophorion urbano. Le indagini sono state condotte sia nell'area destinata alle offerte votive di età proto-ellenistica, sia in quella limitrofa destinata alle attività di preparazione e consumo dei pasti. Lo scavo è proseguito anche presso la ‘vasca’ maggiore (cfr. NotScASNP 2022, per una piccola vasca circolare), in attesa di un intervento volto a definire la natura del riempimento. È stata verificata anche la presenza di fasi precedenti di utilizzo di questa terrazza, ma è ancora difficile dire se siano riferibili a un uso sacro o residenziale. I nuovi dati indicano comunque con forza che il complesso monumentale si delinea sempre più come un santuario urbano di divinità ctonie, caratterizzato da espressioni rituali ben diverse da quelle note per il Thesmophorion suburbano di Contrada Petraro.
Noncontact infrared thermometer measurements offer a reasonable alternative to rectal temperature measurement in afebrile horses
Authors: Zobrist Chelsea N. , Bishop Rebecca C. , McCoy Annette M. 
Published: March 2024

Abstract

OBJECTIVE
To assess the repeatability of infrared thermometer temperature readings and evaluate the correlation between digital rectal temperature and infrared thermometer temperatures taken at different locations in healthy afebrile horses.

ANIMALS
101 afebrile horses ≥ 1 year old.

METHODS
Digital rectal temperatures and infrared temperatures from the eye, gingiva, neck, axilla, and perineum were obtained in a climate-controlled environment and at 2 outdoor ambient temperatures (study period, November 1, 2021, to April 30, 2023).

RESULTS
Infrared temperature measurements were well tolerated by horses, including those resistant to rectal temperature. There was significant correlation between rectal temperature and infrared temperature taken at the perineum (R = 0.57; P < .001) and eye (R = 0.37; P < .001). Infrared temperature measurements were highly repeatable, allowing for calculation of reference ranges for the perineum (36.0 to 37.8 °C) and eye (35.7 to 37.1 °C) in climate-controlled conditions. There was increased variance in outside temperatures compared to climate-controlled conditions for the eye (P = .002), gingiva (P = .047), and perineum (P = .005).

CLINICAL RELEVANCE
While infrared thermometer temperatures were not numerically the same as rectal temperature using a digital thermometer, measurements at the perineum and eye were correlated with rectal temperature readings. Further, the repeatability of infrared readings allows for computation of reference ranges that make the infrared thermometer a viable alternative for the practicing veterinarian when obtaining a temperature in uncooperative horses. The infrared thermometer was reliable outdoors for the eye, but not the perineum. Additional validation of infrared temperature reference ranges in febrile horses and warmer ambient temperatures is warranted.
Diagnosis and outcome of odontogenic abscesses in client-owned rabbits (Oryctolagus cuniculus): 72 cases (2011–2022)
Authors: Levy Ivana , Mans Christoph 
Published: March 2024

Abstract

OBJECTIVE
To characterize the epidemiologic features of rabbits with odontogenic abscesses.

ANIMALS
72 client-owned rabbits.

METHODS
The medical record database of a veterinary teaching hospital was searched to identify rabbits with odontogenic abscesses characterized by a palpable facial mass and confirmed via CT scan. Data reviewed included age, breed, presenting complaint, abscess location, bacterial culture results, treatment, and outcome.

RESULTS
Lop-eared rabbits were the most common breeds affected (20/72 [28%]), and mini lop rabbits were significantly overrepresented. The mandibular quadrants were more frequently affected (65/92 [71%]), and osteomyelitis was a common comorbidity on CT (53/72 [74%]). The most common aerobic and anaerobic isolates were Streptococcus spp (17/40 [43%]) and Fusobacterium spp (10/22 [45%]), respectively. Systemic antibiotic therapy alone was performed in 35 of 62 (56%) treated cases, with documented resolution in 25%. Abscess packing with antibiotic-soaked gauze in conjunction with systemic antibiotic therapy was performed in 20 of 62 (32%) treated cases. Resolution of the odontogenic abscesses with this treatment protocol was documented in 17 of 20 (85%) cases. The number of packing procedures used to obtain resolution of infection was 4 (IQR, 3 to 5).

CLINICAL RELEVANCE
A combination of the abscess-packing technique, which avoids extensive surgery and extraction of the involved elodont teeth, with systemic antibiotic therapy can be an effective treatment option for rabbits with palpable odontogenic abscesses and can result in a high cure rate comparable to more invasive surgical treatments. Antibiotic treatment alone is not recommended, as it has a low chance of abscess resolution.
Assessment of The Efficiency of The Territorial Administrative Reorganization of The Parishes of The District of Braga
Authors: Meneses Nuno Filipe da Silva , Santos Paula Gomes dos , Pinho Carlos Santos 
Published: March 2024

Purpose: The objective of this study was to identify whether the reorganization of parishes carried out in Portugal, in the District of Braga, in 2013, is the one that enhances the greatest efficiency gains.

Theoretical framework: The study is based on the relationship between financial sustainability, efficiency, and territory, seeking the optimal dimension of the local power unit.

Methodology: The study is based on the Data Envelopment Analysis method, using data from the parishes of the district of Braga in two moments, the year 2012 and the year 2015. For this year, a new territorial reorganization was also proposed and analysed.

Results and Conclusions: The reform increased efficiency in 10 of the 14 municipalities. However, it was possible to observe that a reorganization that gives the parishes a larger size, that is, closer to the average seen in the European Union, would bring average efficiency gains in all municipalities. Thus, it is concluded that the reform of the parishes carried out in 2013 in the district of Braga is not the one that allows greater efficiency, since this can be enhanced if they benefit from a larger geographical scale.

Research implications: The research contributes to the knowledge of the efficiency of territorial reforms, namely, regarding the impact of the dimension in this context, as well as to the evaluation of the public policy adopted, allowing the public decision-maker to make a sound and sustained decision.

Originality/value: This study is original because it studies smaller units of local government, the parishes, on which research is very incipient, namely in Portugal.