bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pairing Non‐Solvating Cosolvent with Weakly Solvating Solvents for Facile Desolvation to Enable EC‐Free and High‐Rate Electrolyte for Lithium Ion Batteries
Authors: Liu Qijun , Zeng Ziqi , Qin Mingsheng , Yang Tao , Ma Hongyun , Ji Sheng , Huang Ling , Cheng Shijie , Xie Jia 
Published: February 2024

AbstractThe advancement of lithium‐ion batteries (LIBs) calls for superior electrolyte design to satisfy the booming demands of energy storage markets. Despite being typically indispensable in modern electrolytes, ethylene carbonate (EC) exhibits strong affinity with Li+ and derives organic‐rich SEI, leading to sluggish interfacial dynamics and unsatisfied rate capability. Here, we construct a kinetically favorable electrolyte based on linear carbonates (DMC) and fluoroethylene carbonate (FEC) with functional non‐solvating cosolvent, fluorobenzene (FB). Specifically, DMC and FEC, as weak binding solvents, show facile interfacial kinetics. FB enables a loose coordination chemistry through dipole‐dipole interaction, further lubricating Li+ desolvation and transport through SEI at interphase, which accelerates electrochemical kinetics and enables improved rate performance (257 mA h g−1 is achieved for graphite at 6 C). Moreover, the optimized electrolyte shows decent graphite compatibility, long‐term stability (75 % capacity retention after 350 cycles for NCM622/graphite pouch cells at 1 C) and wide‐temperature adaptability (−40~160 °C). This work reveals that dipole‐dipole interaction between non‐solvating cosolvents and solvents can effectively lower desolvation energy barrier and ultimately enable good rate capability, which provides a new avenue for designing EC‐free electrolyte in high‐rate LIBs.
Use ofOneNoteclass notebook as a combined electronic laboratory notebook and content delivery tool in an introductory biochemistry laboratory course
Authors: Khan‐Trottier Ahlia 
Published: February 2024

AbstractThe COVID‐19 pandemic has forced a shift in thinking regarding the safe delivery of wet laboratory courses. While we were fortunate to have the capacity to continue delivering wet laboratory experiments with physical distancing and other measures in place, modifications to the mechanisms of delivery within courses were necessary to minimize risk to students and teaching staff. One such modification was introduced in BCH370H, an introductory biochemistry laboratory course, where a OneNote Class Notebook (ONCN) was used as an electronic laboratory notebook (ELN) in place of the traditional hardbound paper laboratory notebook (PLN) used prior to the pandemic. The initial reasoning for switching to an ELN was around safety—allowing course staff and students to maintain physical distancing whenever possible and eliminating the need for teaching assistants to handle student notebooks; however, the benefits of the ONCN proved to be significantly more. OneNote acted not only as a place for students to record notes but the Class Notebook's unique features allowed easy integration of other important aspects of the course, including delivery of laboratory manuals, posting of student results, notetaking feedback, sharing of instructional materials with teaching assistants, and more. Student and teacher experiences with the ONCN as used within a fully in person biochemistry laboratory course, as well as learned best practices, are reviewed.
If you are learner‐centered and you know it, raise your hand: Perspectives on and implementation of pedagogical changes by science instructors during the COVID‐19 pandemic
Authors: Donham Cristine , Hong Hanbo , Signorini Adriana , Menke Erik , Kranzfelder Petra 
Published: February 2024

AbstractStudents at Minority‐Serving Institutions (MSIs) faced significant hardships while trying to learn through emergency remote teaching (ERT) during the COVID‐19 pandemic. Our research aims to investigate if science, technology, engineering, and mathematics (STEM) instructors thought about and enacted more learner‐centered teaching practices to alleviate some of this stress encountered by their students. Using semi‐structured interviews and classroom observations, we utilized inductive and deductive qualitative research methods to examine two questions: (1) To what extent were STEM instructor's perceived pedagogical changes learner‐centered during ERT?; and (2) To what extent were STEM instructor's teaching behaviors and discourse practices learner‐centered during ERT? Our findings revealed that during ERT, STEM instructors described using a variety of pedagogical changes that we identified as learner‐centered under the Weimer framework, including ideas such as enacting flexible late policies and increased usage of formative assessment. Interestingly, we found that many of these learned‐centered changes were happening outside of the classroom. Classroom observations assessing instructor behaviors and discourse demonstrated that STEM instructors enacted practices that aligned with Weimer's five constructs of learner‐centered teaching. Our research highlights implications of learner‐centered teaching practices for STEM instructors as well as researchers.
Crystallographically vacancy‐induced MOF nanosheet as rational single‐atom support for accelerating CO2 electroreduction to CO
Authors: Cho Jin Hyuk , Ma Joonhee , Lee Chaehyeon , Lim Jin Wook , Kim Youngho , Jang Ho Yeon , Kim Jaehyun , Seo Myung‐gi , Choi Youngheon , Jang Youn Jeong , Ahn Sang Hyun , Jang Ho Won , Back Seoin , Lee Jong‐Lam , Kim Soo Young 
Published: February 2024

AbstractTo attain a circular carbon economy and resolve CO2 electroreduction technology obstacles, single‐atom catalysts (SACs) have emerged as a logical option for electrocatalysis because of their extraordinary catalytic activity. Among SACs, metal–organic frameworks (MOFs) have been recognized as promising support materials because of their exceptional ability to prevent metal aggregation. This study shows that atomically dispersed Ni single atoms on a precisely engineered MOF nanosheet display a high Faradaic efficiency of approximately 100% for CO formation in H‐cell and three‐compartment microfluidic flow‐cell reactors and an excellent turnover frequency of 23,699 h−1, validating their intrinsic catalytic potential. These results suggest that crystallographic variations affect the abundant vacancy sites on the MOF nanosheets, which are linked to the evaporation of Zn‐containing organic linkers during pyrolysis. Furthermore, using X‐ray absorption spectroscopy and density functional theory calculations, a comprehensive investigation of the unsaturated atomic coordination environments and the underlying mechanism involving CO* preadsorbed sites as initial states was possible and provided valuable insights.
Evidence for glia‐mediated, age‐dependent remodeling of myelin at the axon initial segment
Authors: Furusho Miki , Terasaki Mark 
Published: February 2024

AbstractDue to its proximity to the axon initial segment (AIS), the paranode of the first myelin segment can influence the threshold for action potentials and how a neuron participates in a neuronal circuit. Using serial section electron microscopy, we examined its three‐dimensional (3D) organization in the ventral horn of the mouse spinal cord. The myelin loops of postnatal day 18 mice resemble those at the node of Ranvier. However, in 3‐month‐old mice, 13 of 22 para‐AIS showed 4 types of alteration: (A) A cytoplasmic foot process, with ultrastructural characteristics of an astrocyte, was interposed between the axolemma and the myelin loops. (B) A thin extension of the inner tongue was present between the foot process and axolemma. (C) The foot process was absent. The inner tongue extension was a broad lamella from which a thin extension reached beyond the loops and spiraled around axon. (D) One set of loops was adjacent to the axon, and another was further back and underlain by compact myelin. We suggest that (A)–(C) are steps in a progression toward (D). In this progression, a glial process displaces the original loops, the inner tongue reactivates and extends beneath the foot process, then wraps around the axon to form a new set of loops. This is the first study of the 3D organization of myelin at the AIS and provides evidence for glia‐mediated age‐dependent remodeling at this critical region.
N‐convergence in one–component plasma: Comparison of Coulomb, Ewald, and angular–averaged Ewald potentials
Authors: Demyanov G. S. , Onegin A. S. , Levashov P. R. 
Published: February 2024

AbstractIn this study, we investigate the dependence of potential energy of the one–component plasma on the number of particles with pure Coulomb, Ewald, and angular–averaged Ewald potentials. We show that in the weakly–coupled regime, the Coulomb potential provides a faster convergence of the energy to the thermodynamic limit. However, in the medium‐ and, especially, strong‐coupling regime, the Ewald potential shows significantly better convergence. Thus, the criticism of the Ewald potential in [Fraser et al. Phys. Rev. B 53, 1814 (1996)] within classical simulations turns out to be unjustified in this case: the accounting for long‐range interaction effects greatly improves the ‐convergence of one–component plasma thermodynamic functions.
A novel arc‐shaped four‐port wideband (21.8–29.1 GHz) MIMO antenna with improved characteristics for 5G NR networks
Authors: Nasri Nour El houda , EL GHZAOUI Mohammed , Das Sudipta , Islam Tanvir , Ali Wael , Fattah Mohammed 
Published: February 2024

SummaryA novel antenna system that utilizes multiple‐input and multiple‐output (MIMO) technology to suit the requirements of 5G applications is proposed in this article. The antenna has a wide operating bandwidth and high isolation in n257/n258/n261 5G bands. The suggested arc‐shaped MIMO antenna is composed of four similar patch units with modified ground planes arranged in a four‐port configuration and is made on a Rogers RT/duroid 5880 substrate, which measures 31.891 × 37.5885 × 0.508 mm3. The prototype of the suggested MIMO antenna is realized to confirm the obtained simulated results and validate the proposed design. The four‐port MIMO antenna features a broad frequency range of 7.3 GHz from 21.8 to 29.1 GHz, a peak gain of 5.76 dBi at 29 GHz, and a good isolation less than −18 dB. The proposed antenna's MIMO performance is evaluated by analyzing several diversity parameters. The findings of the evaluation demonstrate an envelope correlation coefficient (ECC) value of less than 0.001, a diversity gain (DG) value exceeding 9.995 dB, and an average mean effective gain (MEG) of −3 dB within the operational frequency band. The suggested MIMO antenna's compact size and impressive performance make it a suitable choice for intended n257/n258/n261 5G NR networks.
Case of lung fine needle aspiration showing mucinous cells and extracellular mucin
Authors: Saliba Maelle , Smithgall Marie C. , Saqi Anjali , Crapanzano John P. , Sung Simon 
Published: February 2024

AbstractMucinous neoplasm with extracellular mucin can be challenging to interpret on fine needle aspiration and core biopsies. Determining the biologic origin of the mucin/mucinous cells, that is, benign/incidental versus neoplasm, invasive versus in situ, and primary versus metastatic tumors, requires a thorough multidisciplinary evaluation. The work up of these lesions includes morphologic analysis with ancillary immunohistochemical and/or molecular studies and correlation with clinical and imaging studies. This review outlines a practical approach to the diagnosis of mucinous lesions in the lung with comprehensive review of literature.
Droplet Laplace valve‐enabled glaucoma implant for intraocular pressure management
Authors: Wang Yuyang , Fang Zecong , Li Sen , Lin Kexin , Zhang Zhifeng , Chen Junyi , Pan Tingrui 
Published: February 2024

AbstractGlaucoma, the leading cause of irreversible blindness worldwide, is closely linked to aqueous overaccumulation and elevated intraocular pressure (IOP). For refractory glaucoma, aqueous shunts with valves are commonly implanted for effective aqueous drainage control and IOP stabilization. However, existing valved glaucoma implants have the disadvantages of inconsistent valve opening/closing pressures, poor long‐term repeatability due to their reliance on moving parts, and complex architectures and fabrication processes. Here, we propose a novel valving concept, the droplet Laplace valve (DLV), a three‐dimensional printable moving‐parts‐free microvalve with customizable and consistent threshold valving pressures. The DLV uses a flow discretization unit governed by capillarity, comprising a droplet‐forming nozzle, and a separated reservoir to digitize continuous flow into quantifiable droplets. Unlike the classic one‐time‐use Laplace valves, the DLV's unique design allows for its reusability. The opening pressure is adjustable by varying the nozzle size, like the classic Laplace valves (following the Young–Laplace equation), while the closing pressure can be modified by tuning the separation distance and the reservoir size. Various DLVs with customizable opening pressures from 5 to 11 mmHg have been demonstrated, with opening/closing pressure differences suppressed down to <0.5 mmHg (<0.15 mmHg under the best conditions). Thanks to its moving‐parts‐free nature and digitized flow properties, the DLV shows a highly repeatable valving performance (<1.7%, 1000 cycles) and a predictable linear flow rate–pressure correlation (R2 > 0.99). Preliminary ex vivo validation in an enucleated porcine eye confirms the DLV's efficiency in aqueous shunting and prompt IOP stabilization. The DLV technology holds great promise in glaucoma implants for IOP management and various microsystems for flow control.
A systematic review of literature on Insulin‐like growth factor‐2‐mediated hypoglycaemia in non‐islet cell tumours
Authors: Ata Fateen , Choudry Hassan , Khan Adeel Ahmad , Anum  , Khamees Ibrahim , Al‐sadi Anas , Mohamed Abdelaziz , Malkawi Lujain , Aljaloudi Esra'a 
Published: February 2024

AbstractIntroductionInsulin‐like growth factor‐2 (IGF‐2)‐mediated hypoglycemia is a rare yet clinically significant entity with considerable morbidity and mortality. Existing literature is limited and fails to offer a comprehensive understanding of its clinical trajectory, management and prognostication.MethodsSystematic review of English‐language articles reporting primary patient data on IMH was searched using electronic databases (PubMed, Scopus and Embase) from any date up to 21 December 2022. Data were analysed in STATA‐16.ResultsThe systematic review contains 172 studies, including 1 Randomised controlled trial, 1 prospective observational study, 5 retrospective observational studies, 150 case reports, 11 case series and 4 conference abstracts. A total of 233 patients were analysed, averaging 60.6 ± 17.1 years in age, with comparable proportions of males and females. The commonest tumours associated with Insulin‐like Growth Factor‐2‐mediated hypoglycaemia were fibrous tumours (N = 124, 53.2%), followed by non‐fibrous tumours originating from the liver (N = 21, 9%), hemangiopericytomas (N = 20, 8.5%) and mesotheliomas (N = 11, 4.7%). Hypoglycaemia was the presenting feature of NICT in 42% of cases. Predominant clinical features included loss of consciousness (26.7%) and confusion (21%). The mean IGF‐2 and IGF‐1 levels were 882.3 ± 630.6 ng/dL and 41.8 ± 47.8, respectively, with no significant correlation between these levels and patient outcomes. Surgical removal was the most employed treatment modality (47.2%), followed by medication therapy. The recovery rate was 77%, with chronic liver disease (CLD) significantly associated with a poor outcome (OR: 7.23, P: 0.03). Tumours originating from fibrous tissues were significantly associated with recovery (p < .001). In the logistic regression model, CLD remained a significant predictor of poor outcomes.ConclusionThis systematic review highlights that most non‐islet‐cell tumour‐hypoglycaemia (NICTH) is due to fibrous tumours. NICTs demonstrate a variable prognosis, which is fair if originating from fibrous tissue. Management such as octreotide, corticosteroids, diazoxide, embolization, radiotherapy and surgical resection have disparate success rates.
Photoinduced Radical Borylation of Alkyl Chlorides
Authors: Bai Lutao , Jiao Lei 
Published: February 2024

AbstractThe traditional method for the preparation of alkylboronic esters involves transition metal catalysis or transition metal‐free methods relying on single electron transfer. Each method relies on the suitable choice of catalyst or electron transfer mediator. In this study, we have developed a new method for the synthesis of alkylboronic esters from alkyl chlorides and diboron(4) compounds, without the need for additional metal or non‐metal catalysts. We discovered that under 400 nm visible light irradiation, alkyl chlorides can be activated in the presence of bis(neopentyl glycolato)diboron and an alkoxide base to form alkyl radical intermediates, which then react with diboron(4) compounds, resulting in high yields of alkylboronic esters. The reaction is applicable to both primary and secondary alkyl chlorides. The simplicity of operation and the broad substrate scope of this method make it practical for the synthesis of valuable alkylboronic ester intermediates.
Kinetic Resolution of a Planar–Chiral [2.2]Paracyclophane via Michael Addition to Nitroolefins Catalyzed by N‐Terminal Guanidinylated Helical Peptide
Authors: Tian Jiaqi , Tamaribuchi Kenya , Yoshikawa Isao , Kudo Kazuaki 
Published: February 2024

AbstractKinetic resolution of 4‐(2‐nitrovinyl)[2.2]paracyclophane based on N‐terminal–guanidinylated resin–bound helical peptide catalyzed asymmetric Michael addition of malonate esters was developed. This approach provides a new pathway to enantiopure paracyclophane derivatives characterized by both planar and central chirality, along with the recovery of the chiral substrate with a selectivity factor of up to 111. Additionally, the synthetic potential of the resulting products has been showcased through their successful transformation into derivatives of β‐substituted γ‐aminobutyric acid.
Aroma release regularities of Rosa damascena from Xuancheng via HS‐GC‐IMS and P&T‐GC–MS
Authors: Wang Haitao , Yao Lingyun , Song Shiqing , Wang Huatian , Sun Min , Liu Qian , Yu Chuang , Feng Tao 
Published: February 2024

AbstractDamascus rose (DR) is an important economic crop. In recent years, DR has been widely planted and utilized in China. In order to improve its aroma quality, the volatile releasing regularities of DR need to be studied. Therefore, HS‐GC‐IMS were used to examine the style of aroma release in DR under three flowering states: pre‐bloom (PB), half‐bloom (HB) and full bloom (FB). The results show that HS‐GC‐IMS detected 56 volatile compounds to investigate the changes of volatile compounds in three states of DR during the growth period. The results of PCA showed that changes in aroma substances were obvious during the growth stage of DR. In addition, FB contributed some key aroma molecules of DR. Thus, volatiles in DR at different times of a day (5 AM, 11 AM, 5 PM) and were further examined by using P&T‐GC–MS towards FB. Finally, a total of 68 volatile compounds were identified; most of them were terpenoids (47.83%–59.62%). Totally 21 volatiles were considered key compounds due to their high concentration (≥1%). These key compounds showed the highest levels at 5 AM and lowest levels at 5 PM. Heat map clustering showed that most of the key compounds possessing higher levels in the flowers had maximum levels at 5 AM and compounds with lower levels peaked at 11 AM. This study will provide a theoretical understanding of the aroma generation mechanism of DR. It also helps the rose farmers to plant and sow rose flowers practically.
Prognostic risk factors of buccal squamous cell carcinoma: A case–control study
Authors: Callander Jacquelyn K. , Souza Spenser S. , Eltawil Yasmin , El‐Sayed Ivan H. , George Jonathan R. , Ha Patrick , Ryan William R. , Xu Mary Jue , Heaton Chase M. 
Published: February 2024

AbstractObjectivesTo describe the clinicopathologic presentation of buccal squamous cell carcinoma and identify risks factors for recurrence and overall survival.MethodsThis is a retrospective case–control study of patients with oral cavity squamous cell carcinoma (OCSCC) treated at a single tertiary care center between 2010 and 2022. All patients with buccal subsite OCSCC treated during this time frame were included and paired with a randomly selected age and gender matched patient with non‐buccal OCSCC. Relevant data was collected via chart review.ResultsSeventy‐seven patients with buccal SCC were matched with 77 non‐buccal OCSCC controls. The median follow‐up time was 27 months (IQR 14–61). Median age was 67 years (IQR 57–75) and 53% of the cohort was female. Twenty (26%) buccal SCC patients experienced a recurrence versus 19 (25%) in the controls. Age ≥65‐years‐old increased odds of all‐cause mortality in the buccal SCC group, but not in the control group. Perineural invasion and positive margins increased odds of recurrence in the buccal group only. Overall survival and progression‐free survival did not differ between the groups, despite a greater number of T2 buccal tumors and T1 non‐buccal tumors.ConclusionsBuccal SCC presents at a higher T stage than other oral cavity SCC subsite and may exhibit variance in the pathologic risk factors that predict poor outcomes versus non‐buccal OCSCC. Despite these relatively minor differences, however, oncologic outcomes between these groups were similar.
KLF4 interacts with TXNIP to modulate the pyroptosis in ulcerative colitis via regulating NLRP3 signaling
Authors: Chen Yuan , Sun Lifeng , Liu Haiyan , Li Jiamei , Guo Lu , Wang Zhiyi 
Published: February 2024

AbstractIntroductionUlcerative colitis (UC) is one of the most common diseases in the gastrointestinal tract related to abnormal inflammation. Pyroptosis, which is characterized by the formation of inflammasome, activation of caspase‐1, and separation of N‐ and C‐terminus of gasdermin D (GSDMD), and may be involved in the pathogenesis of IBD. Krüppel‐like factor 4 (KLF4) is a zinc finger transcription factor expressed in differentiated epithelial cells. KLF4 mediates proinflammatory signaling in macrophages. Here, we tested whether KLF4 is functional in pyroptosis of UC.MethodsIn human UC tissues and/or lipopolysaccharide (LPS)/adenosine 5‐triphosphate (ATP) stimulation human colon epithelial cells, KLF4, TXNIP, Cleave‐Caspase‐1, and GSDMD expression were detected through quantitative reverse transcription polymerase chain reaction (PCR), immunohistochemical and western blot assay. Interleukin (IL)‐1β and IL‐18 levels were quantified by enzyme‐linked immunosorbent assay. We successfully constructed a KLF4‐silenced colon epithelial cell line using an adenovirus vector. We apply the UCSC and JASPAR to predict the KLF4 binding sites in the promoter region of TXNIP.ResultsIn human UC tissues and/or LPS/ATP stimulation human colon epithelial cells, KLF4, TXNIP, Caspase‐1, and GSDMD expression level were significantly elevated via quantitative reverse transcription PCR, immunohistochemical and western blot assay. Moreover, We identified that there is an interaction between KLF4 and TXNIP through Yeast double hybrid assay and CO‐IP assay. We successfully constructed a KLF4‐silenced human intestinal epithelial cell line. In LPS/ATP stimulation KLF4‐silenced human intestinal epithelial cells, KLF4, TXNIP, Cleave Caspase‐1, ASC, and GSDMD expression level were significantly decreased via quantitative reverse transcription PCR.ConclusionOur results confirm that KLF4 can positively regulate the expression of TXNIP and regulate the pyroptosis process of UC through the TXNIP/NLRP3 pathway.