bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Overview of Adalimumab Therapy for Ankylosing Spondylitis
Authors: Sukhanova Anna M. , Gilavian Mariam A. , Melnik Elizaveta V. , Shikh Evgenia V. , Petukhov Alexey E. , Gegechkori Vladimir I. , Dementev Sergey P. , Vlasov Alexander M. , Ramenskaya Galina V. 
Published: March 2024

Background:
Ankylosing spondylitis (AS) is a chronic inflammatory disease known
for causing pain, stiffness, and reduced mobility in the axial skeleton. Adalimumab, a tumor necrosis
factor (TNF) inhibitor, has emerged as a promising therapeutic option for AS.

Methods:
This systematic review involved a comprehensive search of randomized controlled
trials related to AS treatment, conducted in major databases such as MEDLINE, Google Scholar,
and PubMed. The search terms encompassed ankylosing spondylitis, adalimumab, methotrexate,
other non-biologic DMARDs, glucocorticoids, NSAIDs, and analgesics. A total of 14 randomized
controlled trials with 4,500 participants were included in the review.

Results:
The review's results revealed that adalimumab demonstrated notable superiority when
compared to a placebo. It effectively reduced disease activity, improved physical function, and
lowered inflammatory markers such as C-reactive protein and erythrocyte sedimentation rate.
Adalimumab demonstrated a favorable safety profile, with adverse events comparable to those observed
with placebo.

Conclusion:
Based on the results, adalimumab is deemed an effective treatment for AS, showcasing
its potential as a first-line therapeutic option. Notably, no significant increase in adverse
events was observed compared to placebo. However, the conclusion emphasizes the need for further
studies with extended follow-up durations to ascertain the long-term efficacy and safety of
adalimumab in AS management. This systematic review provides valuable insights supporting the
use of adalimumab in the treatment of AS and underscores the importance of ongoing investigations
into its long-term effects to optimize its clinical utilization in AS patients.
Does Post-/Long-COVID-19 Affect Renal Stiffness without Causing any Chronic
Systemic Disorders?
Authors: Çitil Serdal , Aksu Yusuf 
Published: March 2024

Background:
In the last few years, coronavirus disease 2019 (COVID-19) has changed human lifestyle, behavior, and perception of life. This disease is caused
by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). In the literature, there are limited studies about the late renal effects of
COVID-19 that reflect the systemic involvement of this disease.

Aim:
In the present study, we aimed to compare sonoelastographic changes in both kidneys between patients who had totally recovered from COVID-19
and healthy individuals using strain wave elastography (SWE).

Methods:
This study was conducted between June 2021 and May 2022 in Kahramanmaraş City Hospital Department of Radiology. File and archive records
were retrospectively evaluated. Basic demographic, laboratory, and renal ultrasonography (USG) and sonoelastographic findings were screened
and noted. Two groups were defined to compare sonoelastographic findings. Post-long COVID-19 group had 92 post-long COVID-19 patients, and
the comparator group had 9 healthy individuals”. Both groups’ demographic, laboratory, and ultrasound-elastographic findings were assessed.

Results:
The post-long COVID-19 group had a higher renal elastographic value than the comparator group (1.52 [0.77–2.3] vs. 0.96 [0.54–1.54], p<0.001).
There were no statistically significant differences between the two groups in terms of age (p=0.063), gender (p=0.654), or body mass index (BMI)
(p=0.725), however, there was a significant difference observed between the two groups in the renal strain ratio (RSR). According to an ROC
analysis, an RSR cutoff of >1.66 predicted post-long COVID-19 with 44.9% sensitivity and 81.9% specificity. (AUC=0.655, p<0.001). A separate
ROC analysis was performed to predict post-long COVID-19 with a BMI cutoff of <33.52, kg/m2 sensitivity of 92.4% and specificity of 17%
(AUC=0.655, p<0.001).

Conclusion:
We demonstrated that renal parenchymal stiffness increases with SWE in post-long COVID-19 patients.
Multimodal Imaging for the Diagnosis of Massive Left Atrial Metastasis from
Lung Cancer - A Case Report
Authors: Sun Li , Jiao Ronghong , Xing Yuanyuan , Ye Yuquan 
Published: March 2024

Background:
Secondary cardiac tumors are a rare disease that is hard to detect when the tumor is small and asymptomatic. This case report focuses on a massive
pulmonary metastasis filling almost the entire left atrium. Multimodal enhancement imaging, cardiac contrast-enhanced ultrasound (CEUS),
enhanced electron computed tomography, and positron emission tomography imaging were applied to detect the malignant origin of this case. The
aim of this project was to provide an important basis for clinical treatment and decision-making with multimodal imaging.

Case Presentation:
The patient was hospitalized with suspected to be a lumbar spine fracture. According to the multimodal imaging, pathologically confirmed to suffer
a cardiac metastasis from small cell lung cancer. EP-regimen (Etoposide 0.1gd 1-5+Nedaplatin 30mgd 1-4) was selected for the systemic
chemotherapy of the patient. During three years of follow-up, the left intra-atrial occupancy was significantly reduced.

Conclusion:
Multimodality imaging can cover up the deficiencies of single imaging examinations and further clarify and enrich the understanding of the
relationship between the location and the surrounding structure of the mass, thus providing a good reference for clinical treatment and decisionmaking.
Medical Image Fusion Based on Local Saliency Energy and Multi-scale Fractal
Dimension
Authors: Zhou Yaoyong , Zhu Xiaoliang , Zhou Panyun , Xu Zhenwei , Liu Tianliang , Li Wangjie , Ge Renxian 
Published: March 2024

Background:
At present, there are some problems in multimodal medical image fusion, such as texture detail loss, leading to edge contour blurring and image
energy loss, leading to contrast reduction.

Objective:
To solve these problems and obtain higher-quality fusion images, this study proposes an image fusion method based on local saliency energy and
multi-scale fractal dimension.

Methods:
First, by using a non-subsampled contourlet transform, the medical image was divided into 4 layers of high-pass subbands and 1 layer of low-pass
subband. Second, in order to fuse the high-pass subbands of layers 2 to 4, the fusion rules based on a multi-scale morphological gradient and an
activity measure were used as external stimuli in pulse coupled neural network. Third, a fusion rule based on the improved multi-scale fractal
dimension and new local saliency energy was proposed, respectively, for the low-pass subband and the 1st closest to the low-pass subband. Layerhigh
pass sub-bands were fused. Lastly, the fused image was created by performing the inverse non-subsampled contourlet transform on the fused
sub-bands.

Results:
On three multimodal medical image datasets, the proposed method was compared with 7 other fusion methods using 5 common objective
evaluation metrics.

Conclusion:
Experiments showed that this method can protect the contrast and edge of fusion image well and has strong competitiveness in both subjective and
objective evaluation.
Clinical Application of MRI in Coronavirus Disease 2019: A Bibliometric
Analysis
Authors: Hu Jinqun , Xiong Jian , Jiang Jing , Wei Ying , Ling Fayang , Luo Shichun , Chen Jiao , Su Chengguo , Wang Xiao , Qi Wenchuan , Liang Fanrong 
Published: March 2024

Background:
Currently, coronavirus disease 2019 (COVID-19) continues to remain in the pandemic stage, leading to severe challenges in the global public
healthcare system. Magnetic resonance imaging (MRI) methods have played an important role in the diagnosis of COVID-19 and the structural
evaluation of the affected organs. Reviewing and summarizing the application of MRI has significant clinical implications for COVID-19.
Objective: The study aimed to analyze literature related to the application of MRI in COVID-19 using bibliometric tools, to explore the research
status, hotspots, and developmental trends in this field, and to provide a reference for the application of MRI in the clinical diagnosis and
evaluation of COVID-19.

Methods:
We used the Web of Science Core Collection database to search and collect relevant literature on the use of MRI in COVID-19. The authors,
institutes, countries, journals, and keyword modules of the bibliometric analysis software CiteSpace and VOSviewer were used to analyze and plot
the network map.

Results:
A total of 1506 relevant articles were shortlisted through the search; the earliest study was published in 2019, showing an overall upward trend
every year. The research was mainly presented as published articles. Clinical neurology was found to be the primary discipline. The United States
had the highest publication volume and influence in this field. Countries around the world cooperated more closely. The Cureus Journal of Medical
Science was the main periodical to publish articles. Institutes, such as Harvard Medical School, Mayo Clinic, and Massachusetts General Hospital,
have published a large number of papers. Some of the high-frequency keywords were “COVID-19”, “SARS-CoV-2”, “magnetic resonance”,
“myocarditis”, and “cardiac magnetic resonance imaging”. The keyword clustering study showed that the current research mainly focuses on five
“hot” directions.

Conclusion:
There is a need to strengthen cross-teamwork and multidisciplinary collaboration in the future to completely explore the positive role of MRI in
COVID-19 and to discover breakthroughs for the challenges in the clinical diagnosis and treatment of COVID-19.
Latest Developments in Magnetic Resonance Imaging for Evaluating the
Molecular Microenvironment of Gliomas
Authors: Zhang Hanwen , Zhang Hongbo , Lin Fan , Huang Biao 
Published: March 2024

Abstract:
The 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System has brought a transformative shift in the
categorization of adult gliomas. Departing from traditional histological subtypes, the new classification system is guided by molecular genotypes,
particularly the Isocitrate Dehydrogenase (IDH) mutation. This alteration reflects a pivotal change in understanding tumor behavior, emphasizing
the importance of molecular profiles over morphological characteristics. Gliomas are now categorized into IDH-mutant and IDH wildtype, with
significant prognostic implications. For IDH-mutant gliomas, the concurrent presence of Alpha-Thalassemia/mental retardation syndrome X-linked
(ATRX) gene expression and co-deletion of 1p19q genes further refine classification. In the absence of 1p19q co-deletion, further categorization
depends on the phenotypic expression of CDKN2A/B. Notably, IDH wildtype gliomas exhibit a poorer prognosis, particularly when associated
with TERT promoter mutations, EGFR amplification, and +7/-10 co-deletion. Although not part of the new guidelines, the methylation status of
the MGMT gene is crucial for guiding alkylating agent treatment. The integration of structural and functional Magnetic Resonance Imaging (MRI)
techniques may play a vital role in evaluating these genetic phenotypes, offering insights into tumor microenvironment changes. This multimodal
approach may enhance diagnostic precision, aid in treatment planning, and facilitate effective prognosis evaluation of glioma patients.
Influence of the Presence of Sulfur and Oxygen Atoms on Molecular,
Thermodynamic and Transport Properties in Hydrocarbon Mixtures
Authors: Perez-Sanchez Josue Francisco , del Carmen Galindo-Lopez Ruth , Suarez Dominguez Edgardo Jonathan , Rodriguez-Rodriguez Jpsé Rafael , Perez-Badell Yoana , Izquierdo Kulich Elena Francisco 
Published: March 2024

Introduction:
Crude oil is a complex blend of various hydrocarbon families, with compositions
that vary depending on the source well and exploitation duration. To categorize its constituents,
SARA analysis divides them into saturated, aromatic, resins, and asphaltenes. Heavy asphaltene-
rich crude oils can present challenges like viscosity and pipeline blockages, which are often
addressed with viscosity-reducing additives. However, a theoretical framework explaining how these
additives affect crude oil is lacking, relying primarily on empirical observations. To optimize these
additives, it is crucial to understand the underlying chemical and physical processes. This study hypothesizes
that asphaltenic crude oils influence viscosity through colloidal properties linked to molecular
interactions.

Methods:
The research aimed to analyze the impact of sulfur in asphaltenes and oxygen in flow improvers
on the transport properties of an idealized crude oil, with the goal of predicting additive feasibility.
A methodology that combined computational quantum chemistry and statistical thermodynamics
was used. An idealized model of crude oil was created, consisting of non-polar alkanes and
polar asphaltenes with sulfur atoms. A flow improver was simulated with an aromatic-aliphatic structure
containing oxygen and hydroxyl groups, and viscosity was calculated.

Results:
This study assessed the transport properties of the mixture using principles of statistical
thermodynamics. The theoretical insights revealed that reducing viscosity in asphaltene-rich crude
oils with additives depends on several critical factors, including the formation of the dispersed phase,
the reduced viscosity of the additive, and the effects of dilution. The research identified a strong link
between the enhanced effectiveness of these additives and their structural and molecular properties.

Conclusion:
The theoretical results suggest that additives that act as viscosity reducers in asphalt
crudes achieve optimal performance when they possess both higher polarity and reduced viscosity.
Perils and Problems in Bispecific T-Cell Engager Antibodies
Authors: Khushboo Bisht , Kumar Joshi Rajat 
Published: March 2024

Abstract:
Bispecific antibodies (BsAbs) are promising immunotherapies for cancer treatment designed
to engage both tumour and immune cells. However, their use is associated with potential
toxicities, including cytokine release syndrome (CRS), neurotoxicity, and on-target, off-tumour
toxicity. CRS, characterized by cytokine release, is the most common, potentially life-threatening
toxicity. Neurotoxicity presents as neurological symptoms and on-target, off-tumour toxicity damages
healthy cells. Incidence and severity vary based on BsAb type, dose, patient factors, and tumor
characteristics. For this study, articles pertaining to BsAb toxicity were searched on PubMed.
Moreover, the management involves early recognition, dose modification, supportive care, and, in
severe cases, immunosuppressive therapy or treatment discontinuation. Clinicians must carefully
assess risks and benefits, considering individual patient profiles. Close monitoring and multidisciplinary
collaboration are crucial for effective BsAb therapy. All in all, while toxicity is a concern,
with vigilant management, BsAbs remain a valuable cancer treatment option.
Inhibition of MiR-155 Using Exosomal Delivery of Antagomir Can
Up-Regulate PTEN in Triple Negative Breast Cancer
Authors: Razaviyan Javad , Sirati-Sabet Majid , Tafti Ali , Hadavi Razie , Karima Saeed , Rajabibazl Masoumeh , Mohammadi-Yeganeh Samira 
Published: March 2024

Background:
The most aggressive form of breast cancer (BC) is Triple-Negative BC
(TNBC), with the poorest prognosis, accounting for nearly 15% of all cases. Since there is no
effective treatment, novel strategies, especially targeted therapies, are essential to treat TNBC.
Exosomes are nano-sized microvesicles derived from cells and transport various intracellular
cargoes, including microRNAs (miRNAs). MiRNAs, small non-coding RNA, are an influential
factor in the development of cancerous transformations in cells.

Methods:
Bioinformatics analysis of genes related to TNBC revealed that PTEN plays a crucial
role in the disease. Relative expression of this gene was analyzed with RT-qPCR in 14 TNBC
clinical samples. Electroporation was used to load miRNA antagomir into exosomes extracted
from the conditioned medium. Then, the expression of miR-155 and PTEN was evaluated in
MDA-MB-231 cells treated with antagomir-loaded exosomes.

Results:
Based on the bioinformatics analysis, miR-155 is a potent inhibitor of PTEN. Following
treatment with antagomir-loaded exosomes, RT-qPCR showed significantly reduced miR-
155 and increased PTEN levels in MDA-MB-231 cells.

Conclusion:
Based on the results of this study, exosomes can be effectively used as a cargo of
oligonucleotides like miRNA mimics and antagomirs in targeted therapies.
A Comprehensive Review on the Traditional Uses, Phytochemical
Compositions and Pharmacological Properties of an Ethnomedicinal
Herb, Paederia foetida
Authors: Barai Samir , Roy Subhrajyoti , Bhattacharyya Shubham , Hore Mayukh 
Published: March 2024

Background::
Paederia foetida L. (Family – Rubiaceae) is a common herb found
available in the temperate and tropical Asia. The ethnomedicinal applications of this plant are
widely elaborated In Chinese Traditional Medicine, Ayurveda, and other ancient scriptures
throughout the world. Different ethnic groups use this plant in the treatment of alimentary and
digestive disorders, bone related diseases like rheumatoid arthritis, bone fractures as well as in
the ailments of diabetes, coughs, asthma, itches, wounds, body ache, toothache, cancer etc.

Objectives::
This comprehensive review aims to provide an insightful understanding of traditional
uses, chemical composition, and pharmacological properties of P. foetida (from 1976 up to
2023), which may provide a foundation for further study and for the proper utilization of P. foetida
resources.

Methods::
Literature survey was conducted using known databases and the relevant keywords.

Results::
P. foetida has been widely used in Chinese traditional medicine (CTM) for the treatment
of dyspepsia, jaundice, pains, diarrhea and others. Several ethnic groups throughout the
world used this plant to cure common health complaints namely, abdominal pain, gastritis, dysentery,
diarrhoea, constipation, joint pain, etc. A total of 24 bioactive phytocompounds, such as
asperuloside, paederosidic acid, sitosterols, stigmasterol, campesterol, ellagic acid, iridoids, ursolic
acid, epifriedelinol, and others are reported to possess antiulcer, antidiarrheal, antihyperglycemic,
antioxidant, antitussive, anthelmintic, and hepatoprotective activities.

Conclusion::
The present review not only summarizes the alternative approaches using this herb
by ethnic people for treating various disorders, but also focuses on the latest scientific investigations
to elucidate different bioactivities of this plant, thereby facilitating the understanding of its
correlation with contemporary pharmacology. However, till date, very few studies elucidated the
biological properties of these phytochemicals that were isolated exclusively from this particular
plant. Moreover, the correlation between phytocompounds from P. foetida and its pharmacological
activities aiming towards clinical drug development is still lacking. Finally, further research
should be oriented towards determining the optimal dosage and toxicological limits, and thereby
providing guidance for clinical applications.
Andrographolide-A Magical Bioactive Compound: An Overview
Authors: Shukla Ajay Kumar , Yadav Vimal Kumar , Maurya Rahul Kumar , Mishra Rahul , Srivastava Shefali , Mishra Manoj Kumar 
Published: March 2024

Abstract:
Andrographis paniculata (ANP) is a medicinal plant containing several bioactive
compounds, such as diterpenoids, flavonoids, and polyphenols. Andrographolide is one of the
key natural compounds which are found in the Andrographis paniculata plant. It has been used
as an Immunomodulators, antiviral, anti-inflammatory, analgesic, anti-cancer, hepatoprotective,
cardioprotective, and managing COVID-19, chikungunya virus (CHIKV) infections etc, due to
the key bioactive compound Andrographolide; therefore, this molecule called a magic bioactive
molecule. Many people have cured and increased their immunity by regularly taking this herb in
the form of tea. All of these potential properties of this bioactive molecule make it very unique.
Therefore, there needs to be more research work for the development of novel properties and
future prospects.
Efficacy of Marham-e-Dakhilyun Ointment and Alum Perineal Wash for
Perineal Wound Healing and Pain Intensity in Postpartum Women: A
Self-control Clinical Trial
Authors: Sultana Arshiya , Rahman Khaleequr , Begum Wajeeha , Begum Arfa , Banu Taseen , Heyat Md Belal Bin 
Published: March 2024

Background and Objective::
Episiotomy, worldwide, is the most frequently performed
obstetric surgical procedure. Delayed wound healing potentially amplifies the risk of wound infection,
structural muscular alterations, and ultimately contributes to the loss of muscle tone. In
addition, rapid and complete repair of the episiotomy or perineal tear is very important as the
pain and discomfort of episiotomy wounds may affect the quality of life of postnatal mothers.
Therefore, we aimed to determine the efficacy of Marham-e-Dakhilyun ointment and alum
perineal wash on perineal wound healing and pain intensity in postnatal mothers.

Materials and Methods::
A single-arm self-controlled study was conducted on postnatal mothers
aged 18 to 40 years, who underwent full-term normal cephalic singleton vaginal delivery with
episiotomy and/or 1st, 2nd, or 3rd-degree perineal tears. The recommended external care regimen
for a period of 10 days involved perineal wash with a solution of alum powder (2
gm/500ml), followed by the application of Marham-e Dakhilyun ointment twice daily to the perineal
wound. For the primary evaluation of wound healing, the REEDA (redness, edema, ecchymosis,
discharge, and approximation) scale has been utilized, while the secondary assessment
involved the use of the VAS (visual analog scale) pain intensity scale. The therapeutic outcome
was determined based on the grading of REEDA scores on days 10-14 and VAS scores.

Results::
We observed our trial medicine showed complete wound healing in 86.4% on days 10-
14. The mean pain reduction percentage (PR %) was 96.85% on days 10-14 from baseline. The
REEDA score was 2.41±0.81 and 0.23±0.61 at one hour and day 10-14, respectively, with significant
differences (p < 0.001). The VAS score was 2.86±1.08 and 0.09±0.29 at one hour and
day 10-14, respectively, with significant differences (p < 0.001). Therefore, the trial ointment
and alum have demonstrated beneficial effects in promoting perineal wound healing and alleviating
pain in postnatal mothers.

Conclusion::
The potential efficacy of Marham-e-Dakhilyun can be attributed to its composition
of various phytoconstituents, such as oleuropein, phenolic acids, flavonols, flavones, linoleic
acid isovitexin, vitexin vanillic acid, salicylic acid, beta-D-glucopyranoside, olanigroside Y1,
solasonine, gallic acid, aucubin, scopoletin, and lantamajoside. These constituents have been
proven in research studies to possess anti-inflammatory, wound healing, antimicrobial, analgesic,
and antioxidant properties. The investigators have optimized the use of these Unani medicines
to provide clinical evidence supporting their effectiveness in the wound-healing process
and in reducing pain intensity.