bluuebunny/crossref_metadata_2025_split huggingface dataset:
A daily investigation of the influence of different types of being envied on the envied employees
Authors: Wang Feng , Fu Rong , Yang Fu , Yingwei Ren 
Published: March 2024

Purpose
Although the targets of envy have received increasing attention in management research, how envied employees respond to envy remains ambiguous and merits further investigation. Drawing upon regulatory focus theory, this paper aims to reconcile these inconsistent findings by developing and testing a model that elucidates how different types of being envied (i.e. benignly or maliciously) can elicit either favorable or unfavorable motivational and behavioral reactions.

Design/methodology/approach
An experience sampling study was conducted on 131 employees across 10 consecutive workdays in China. Focusing on within-person effects, multilevel mediation models using multilevel structural equation modeling were applied.

Findings
Results indicated that on days when employees are benignly envied, they engage in more organizational citizenship behavior (OCB) due to increased daily promotion focus. On the contrary, on days when employees are maliciously envied, they participate in more counterproductive work behavior (CWB) due to decreased daily promotion focus.

Practical implications
Organizations and managers should take a more holistic view of workplace envy when considering that envied employees may use OCB to deal with benign envy. Conversely, considering that CWB may emerge from employees who are maliciously envied, it is crucial for managers to be vigilant in discouraging and addressing malicious envy in the workplace.

Originality/value
This paper takes an initial foray into incorporating the concepts of benign envy and malicious envy into the literature on being envied and provides a novel perspective to explain why being envied can lead to both functional and dysfunctional responses.
Consumer knowledge in marketing: a critical review and research agenda
Authors: Garrido-Castro Elisa , Torres-Peña Francisco-José , Murgado-Armenteros Eva-María , Torres-Ruiz Francisco Jose 
Published: March 2024

Purpose
The purpose of this study is to critically review consumer knowledge in marketing and propose a future research agenda. Despite the many works that have examined this variable, given its strong influence on behaviour, it has generally been studied in association with other constructs, and no studies have focused on it in a specific way. Its definition, measurement and approaches to its role and usefulness are superficial and underdeveloped. After structuring and analysing the existing literature, the authors establish, (I) which aspects are of little use to the discipline, and (II) which research lines have the most potential and should be developed and studied in greater depth, to advance and complete the existing consumer knowledge framework.

Design/methodology/approach
A search was undertaken for documents in the main databases in which the term “consumer knowledge” appears in a marketing or consumer context, and a critical and reflexive approach was taken to analyse the main contributions and to structure them by content blocks.

Findings
Five main content blocks were identified. A set of research gaps were detected, mainly related to the lax conceptualisation of the topic, measurement problems and the scarcity of more useful works connected with business management, and several research lines are proposed that complement the existing framework to make it more complete and operational.

Originality/value
This paper offers a critical review and proposes a research agenda for one of the most used but little studied variables in the field of marketing, which may help academics and professionals in the discipline to continue developing useful theories and models.
Long‐term follow‐up results from KEYNOTE‐041: Phase 1b study of pembrolizumab in Japanese patients with advanced melanoma
Authors: Yokota Kenji , Takenouchi Tatsuya , Fujisawa Yasuhiro , Fukushima Satoshi , Uchi Hiroshi , Inozume Takashi , Kiyohara Yoshio , Uhara Hisashi , Nakagawa Kazuhiko , Furukawa Hiroshi , Han Shirong , Watanabe Masaru , Noguchi Kazuo , Yamazaki Naoya 
Published: March 2024

AbstractPembrolizumab demonstrated an acceptable safety profile and promising antitumor activity in Japanese patients with advanced melanoma in the phase 1b KEYNOTE‐041 (Study of Pembrolizumab [MK‐3475] in Participants With Advanced Melanoma) trial. To evaluate the long‐term efficacy and safety of pembrolizumab in Japanese patients with advanced melanoma in KEYNOTE‐041. The current analysis reports results of additional follow‐up of approximately 12 months since the initial analysis. Eligible patients had locally advanced (unresectable stage III) or metastatic (stage IV) melanoma not amenable to local therapy and had received two or fewer prior systemic therapies. Pembrolizumab 2 mg/kg was given every 3 weeks for up to 2 years or until confirmed progression or unacceptable toxicity. Primary end points included safety, tolerability, and overall response rate (ORR) per Response Evaluation Criteria in Solid Tumors version 1.1 by independent central review. The data cutoff for this analysis was August 30, 2017. Forty‐two patients were followed up for a median of 22.3 months (range, 2.63–30.82 months). The ORR was 24.3% (nine of 37 evaluable patients [95% confidence interval (CI), 11.8%–41.2%]). Two patients with partial response at the time of the initial analysis achieved complete response. The median overall survival (OS) was 25.1 months (95% CI, 13.1–not reached] and the 30‐month OS rate was 46.3% (95% CI, 29.8%–61.3%). The median duration of response was not reached. Treatment‐related adverse events (TRAEs) were reported in 78.6% of patients; the incidence of grade 3 to 5 TRAEs was 23.8%. No additional treatment‐related deaths occurred since the initial analysis. Pembrolizumab provided durable antitumor activity and an acceptable safety profile in Japanese patients with advanced melanoma.
Stem decomposition of temperate tree species is determined by stem traits and fungal community composition during early stem decay
Authors: Yang Shanshan , Poorter Lourens , Sterck Frank J. , Cornelissen Johannes H. C. , van Logtestijn Richardus S. P. , Kuramae Eiko E. , Kowalchuk George A. , Hefting Mariet M. , Goudzwaard Leo , Chang Chenhui , Sass‐Klaassen Ute 
Published: March 2024

Abstract

Dead trees are vital structural elements in forests playing key roles in the carbon and nutrient cycle. Stem traits and fungal community composition are both important drivers of stem decay, and thereby affect ecosystem functioning, but their relative importance for stem decomposition over time remains unclear.

To address this issue, we used a common garden decomposition experiment in a Dutch larch forest hosting fresh logs from 13 common temperate tree species. In total, 25 fresh wood and bark traits were measured as indicators of wood accessibility for decomposers, nutritional quality and chemical or physical defence mechanisms. After 1 and 4 years of decay, we assessed the richness and composition of wood‐inhabiting fungi using amplicon sequencing and determined the proportional wood density loss.

Average proportional wood density loss for the first year was 18.5%, with further decomposition occurring at a rate of 4.3% year−1 for the subsequent 3 years across tree species. Proportional wood density loss varied widely across tree species in the first year (8.7–24.8% year−1) and subsequent years (0–11.3% year−1). The variation was directly driven by initial wood traits during the first decay year, then later directly driven by bark traits and fungal community composition. Moreover, bark traits affected the composition of wood‐inhabiting fungi and thereby indirectly affected decomposition rates. Specifically, traits promoting resource acquisition of the living tree, such as wide conduits that increase accessibility and high nutrient concentration, increased initial wood decomposition rates. Fungal community composition, but not fungal richness explained differences in wood decomposition after 4 years of exposure in the field, where fungal communities dominated by brown‐rot and white‐rot Basidiomycetes were linked to higher wood decomposition rate.

Synthesis: Understanding what drives deadwood decomposition through time is important to understand the dynamics of carbon stocks. Here, using a tailor‐made experimental design in a temperate forest setting, we have shown that stem trait variation is key to understanding the roles of these drivers; initially, wood traits explained decomposition rates while subsequently, bark traits and fungal decomposer composition drove decomposition rates. These findings inform forest management with a view to selecting tree species to promote carbon storage.
‘It's the Programmes, Stupid’
Authors: Younge Pat , Hughes Rosaleen 
Published: March 2024

AbstractPublic Service Broadcasting (PSB) is an eco‐system where the whole is more than the sum of its parts. The BBC is the cornerstone, but ITV, C4, C5 and independent production companies also play a crucial part. The essence of PSB lies in the values which underpin the content, ranging from popular sport and light entertainment to more niche minority strands. The BBC licence fee generates considerable value for the British economy throughout the nations and regions of the UK. This is multiplied by the intellectual property framework for independent production companies. The system is now under threat from the financial squeeze on the BBC licence fee, failure to deliver ‘due prominence’ to commercial PSBs, new technology and changing patterns of consumption. It is essential that a broad range of programmes remain freely available to avoid the cultural, social and political divisions of a two‐tier system of national broadcasting.
The Case for a Strong BBC. Cultural Sovereignty and Public Service Broadcasting in the Netflix Era
Authors: Thompson Mark 
Published: March 2024

AbstractPSBs across the world are facing financial, technological and political pressures, yet audiences still need and want the benefits of public service media. If they are to survive, PSBs need to produce an agile response to the changing patterns of media consumption and the claims that markets can provide. Whilst the big streamers have produced great global content, they are unable to cover the range of the PSBs in reflecting the diversity and variety of British life and culture, nor take the same risks in nurturing new talent across the sector. Politicians must use the forthcoming BBC Charter renewal in 2027 to address the revolution in audience behaviour and changes in technology to reshape the choices available to the British public and beyond. The creative industries are a powerhouse of talent and contribute to some of our best prospects for global reach and economic growth. We must ensure they have a healthy future.
BBC Northern Ireland and the Public Service Challenge: Some Reflections
Authors: Collins Bob 
Published: March 2024

AbstractBroadcasting in Northern Ireland reflects the abiding influence of conflict between the nationalist and unionist communities and the perception of Northern Ireland as a place somewhat apart. Decisions about broadcast content are made in an environment where each community expects to see itself and can be disturbed to find the other. But there are other communities, as well as many people, who do not think in binary terms. Broadcasting needs to respond to that and to the changing demography, with its more varied and nuanced views. BBCNI lacks both the governance and the resources to respond to this challenge. Key decisions are made in London, where the task ahead is not well understood and priorities can appear oriented towards a different audience.
Combinatorial transcriptomic and genetic dissection of insulin/IGF‐1 signaling‐regulated longevity in Caenorhabditis elegans
Authors: Ham Seokjin , Kim Sieun S. , Park Sangsoon , Kwon Hyunwoo C. , Ha Seokjun G. , Bae Yunkyu , Lee Gee‐Yoon , Lee Seung‐Jae V. 
Published: March 2024

AbstractClassical genetic analysis is invaluable for understanding the genetic interactions underlying specific phenotypes, but requires laborious and subjective experiments to characterize polygenic and quantitative traits. Contrarily, transcriptomic analysis enables the simultaneous and objective identification of multiple genes whose expression changes are associated with specific phenotypes. Here, we conducted transcriptomic analysis of genes crucial for longevity using datasets with daf‐2/insulin/IGF‐1 receptor mutant Caenorhabditis elegans. Our analysis unraveled multiple epistatic relationships at the transcriptomic level, in addition to verifying genetically established interactions. Our combinatorial analysis also revealed transcriptomic changes associated with longevity conferred by daf‐2 mutations. In particular, we demonstrated that the extent of lifespan changes caused by various mutant alleles of the longevity transcription factor daf‐16/FOXO matched their effects on transcriptomic changes in daf‐2 mutants. We identified specific aging‐regulating signaling pathways and subsets of structural and functional RNA elements altered by different genes in daf‐2 mutants. Lastly, we elucidated the functional cooperation between several longevity regulators, based on the combination of transcriptomic and molecular genetic analysis. These data suggest that different biological processes coordinately exert their effects on longevity in biological networks. Together our work demonstrates the utility of transcriptomic dissection analysis for identifying important genetic interactions for physiological processes, including aging and longevity.
Can a health warning label diminish the persuasive effects of health‐oriented nutrition advertising on ready‐to‐drink alcohol product packaging? A randomized experiment
Authors: Hobin Erin , Thielman Justin , Forbes Samantha M. , Poon Theresa , Bélanger‐Gravel Ariane , Demers‐Potvin Élisabeth , Haynes Ashleigh , Li Ye , Niquette Manon , Paradis Catherine , Provencher Véronique , Smith Brendan T. , Wells Samantha , Atkinson Amanda , Vanderlee Lana 
Published: March 2024

AbstractBackground and aimsA health warning label (HWL) cautioning about the link between alcohol and cancer may be able to communicate alcohol risks to consumers and potentially counter health‐oriented nutrition advertising on ready‐to‐drink alcoholic beverages. This study aimed to examine the independent and combined effects of nutrient content claims (e.g. 0 g sugar) and a HWL on perceived product characteristics and intentions to consume, and whether these effects differed by gender and age.DesignA between‐subjects randomized experiment. Participants were randomized to view one of six experimental label conditions: nutrient content claims plus nutrition declaration (NCC + ND), ND only, NCC + ND + HWL, ND + HWL, HWL only and no NCC, ND or HWL, all on a ready‐to‐drink (RTD) vodka‐based soda container.Setting and participantsAlcohol consumers (n = 5063; 52% women) in Canada aged 18–64 recruited through a national online panel.MeasurementsParticipants completed ratings of perceived product characteristics, perceived product health risks, and intentions to try, buy, binge and drink the product.FindingsCompared with the reference condition NCC + ND (current policy scenario in Canada), the other five experimental label conditions were associated with lower ratings for perceiving the product as healthy. All experimental conditions with a HWL were associated with lower product appeal, higher risk perceptions and reduced intentions to try, buy and binge. The experimental condition with a HWL only was associated with intentions to consume fewer cans in the next 7 days (β = −0.72, 95% confidence interval [CI] = −1.37,−0.08) versus the reference. Few interactions were observed, suggesting that label effects on outcomes were similar by gender and age.ConclusionsHealth warning labels on alcohol packaging appear to be associated with lower product appeal, higher perceived health risks and reduced consumption intentions, even in the presence of nutrient content claims.
Anatomy and histology of the male reproductive tract of the parasitoid wasp Hymenoepimecis bicolor (Brullé, 1846) (Hymenoptera: Ichneumonidae)
Authors: Silva Laryssa Lemos , Cossolin Jamile Fernanda Silva , Kloss Thiago Gechel , Alvim Jessica Roberta Lacerda , Reis Aline Beatriz , Zanuncio José Cola , Castro Bárbara Monteiro de Castro e , Serrão José Eduardo 
Published: March 2024

AbstractHymenoepimecis wasps (Hymenoptera: Ichneumonidae) are ectoparasitoids of spiders that modify the hosts’ behaviour by inducing changes in webs. Variations in the male reproductive tract contribute to enhancing our understanding of the reproductive behaviour of these insects. This study describes the morphology of the male reproductive tract of Hymenoepimecis bicolor (Brullé, 1846) using light microscope. The male reproductive tract of H. bicolor consists of a pair of testes, each containing a single follicle, two vasa deferentia, one ejaculatory duct and two accessory glands. The testis follicle has cysts at various stages of spermatogenesis, indicating ongoing sperm cell development and maturation. The vasa deferentia are elongated, with a coiled distal portion, whereas the proximal regions are laterally associated with a pair of accessory glands. The wall of the vasa deferentia has simple cuboidal epithelium. The accessory glands had a simple columnar epithelium with the lumen filled with heterogeneous content. The seminal vesicle is absent. The similarity in the anatomy and histology of the male reproductive tract of H. bicolor with other Hymenoptera suggests that the parasitoid behaviour does not result in significant alteration to their reproductive organs, indicating that the reproductive tract is conserved in Hymenoptera, regardless of their behaviours.
The importance of ABO in platelet refractoriness, an often overlooked option
Authors: Gammon Richard , Mo Allison 
Published: March 2024

ABO‐non‐identical (ni) platelets provide less of an increase in platelet count and may increase the length of patient transfusions. The paper by Han and Badami showed that ABO‐ni platelets may be a risk factor for immune platelet transfusion refractoriness.Commentary on: Han et al. ABO non‐identical platelet transfusions, immune platelet refractoriness and platelet support. Br J Haematol 2024;204:2097‐2102.
Minimal CompositionalityversusBird Implicatures: two theories ofABC‐Dsequences in Japanese tits
Authors: Schlenker Philippe , Salis Ambre , Leroux Maël , Coye Camille , Rizzi Luigi , Steinert‐Threlkeld Shane , Chemla Emmanuel 
Published: March 2024

ABSTRACTIt was argued in a series of experimental studies that Japanese tits (Parus minor) have an ABC call that has an alert function, a D call that has a recruitment function, and an ABC‐D call that is compositionally derived from ABC and D, and has a mobbing function. A key conclusion was that ABC‐D differs from the combination of separate utterances of ABC and of D (e.g. as played by distinct but close loudspeakers). While the logic of the argument is arguably sound, no explicit rule has been proposed to derive the meaning of ABC‐D from that of its parts. We compare two analyses. One posits a limited instance of semantic compositionality (‘Minimal Compositionality’); the other does without compositionality, but uses instead a more sophisticated pragmatics (‘Bird Implicatures’). Minimal Compositionality takes the composition of ABC and D to deviate only minimally from what would be found with two independent utterances: ABC means that ‘there is something that licenses an alert’, D means that ‘there is something that licenses recruitment’, and ABC‐D means that ‘there is something that licenses both an alert and recruitment’. By contrast, ABC and D as independent utterances yield something weaker, namely: ‘there is something that licenses an alert, and there is something that licenses recruitment’, without any ‘binding’ across the two utterances. The second theory, Bird Implicatures, only requires that ABC‐D should be more informative than ABC, and/or than D. It builds on the idea, proposed for several monkey species, that a less‐informative call competes with a more informative one (the ‘Informativity Principle’): when produced alone, ABC and D trigger an inference that ABC‐D is false. We explain how both Minimal Compositionality and Bird Implicatures could have evolved, and we compare the predictions of the two theories. Finally, we extend the discussion to some chimpanzee and meerkat sequences that might raise related theoretical problems.
Microsatellite instability: A 2024 update
Authors: Yamamoto Hiroyuki , Watanabe Yoshiyuki , Arai Hiroyuki , Umemoto Kumiko , Tateishi Keisuke , Sunakawa Yu 
Published: March 2024

AbstractDeficient mismatch repair (dMMR) results in microsatellite instability (MSI), a pronounced mutator phenotype. High‐frequency MSI (MSI‐H)/dMMR is gaining increasing interest as a biomarker for advanced cancer patients to determine their eligibility for immune checkpoint inhibitors (ICIs). Various methods based on next‐generation sequencing (NGS) have been developed to assess the MSI status. Comprehensive genomic profiling (CGP) testing can precisely ascertain the MSI status as well as genomic alterations in a single NGS test. The MSI status can be also ascertained through the liquid biopsy‐based CGP assays. MSI‐H has thus been identified in various classes of tumors, resulting in a greater adoption of immunotherapy, which is hypothesized to be effective against malignancies that possess a substantial number of mutations and/or neoantigens. NGS‐based studies have also characterized MSI‐driven carcinogenesis, including significant rates of fusion kinases in colorectal cancers (CRCs) with MSI‐H that are targets for therapeutic kinase inhibitors, particularly in MLH1‐methylated CRCs with wild‐type KRAS/BRAF. NTRK fusion is linked to the colorectal serrated neoplasia pathway. Recent advances in investigations of MSI‐H malignancies have resulted in the development of novel diagnostic or therapeutic techniques, such as a synthetic lethal therapy that targets the Werner gene. DNA sensing in cancer cells is required for antitumor immunity induced by dMMR, opening up novel avenues and biomarkers for immunotherapy. Therefore, clinical relevance exists for analyses of MSI and MSI‐H‐associated genomic alterations in malignancy. In this article, we provide an update on MSI‐driven carcinogenesis, with an emphasis on unique landscapes of diagnostic and immunotherapeutic strategies.
Novel copy number variations and phenotypes of infantile epileptic spasms syndrome
Authors: Cheng Miaomiao , Bai Ling , Yang Ying , Liu Wenwei , Niu Xueyang , Chen Yi , Tan Quanzhen , Yang Xiaoling , Wu Qixi , Zhao Han‐Qing , Zhang Yuehua 
Published: March 2024

AbstractWe summarize the copy number variations (CNVs) and phenotype spectrum of infantile epileptic spasms syndrome (IESS) in a Chinese cohort. The CNVs were identified by genomic copy number variation sequencing. The CNVs and clinical data were analyzed. 74 IESS children with CNVs were enrolled. 35 kinds of CNVs were identified. There were 11 deletions and 5 duplications not reported previously in IESS, including 2 CNVs not reported in epilepsy. 87.8% were de novo, 9.5% were inherited from mother and 2.7% from father. Mosaicism occurred in one patient with Xq21.31q25 duplication. 16.2% (12/74) were 1p36 deletion, and 20.3% (15/74) were 15q11‐q13 duplication. The age of seizure onset ranged from 17 days to 24 months. Seizure types included epileptic spasms, focal seizures, tonic seizures, and myoclonic seizures. All patients displayed developmental delay. Additional features included craniofacial anomaly, microcephaly, congenital heart defects, and hemangioma. 29.7% of patients were seizure‐free for more than 12 months, and 70.3% still had seizures after trying 2 or more anti‐seizure medications. In conclusion, CNVs is a prominent etiology of IESS. 1p36 deletion and 15q duplication occurred most frequently. CNV detection should be performed in patients with IESS of unknown causes, especially in children with craniofacial anomalies and microcephaly.