bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermal‐Conductive MOFs@BN Self‐Supporting Foams for Synchronously Boosting CO2 Adsorption/Desorption
Authors: Li Sheng , Yu Xin , Liu Liming , Zhou Liqin , Jia Zhaowei , Chen Jianmin , Zhao Zhongxing , Zhao Zhenxia 
Published: April 2024

AbstractSynchronous boosting adsorption and desorption efficiency is a great challenge for CO2 adsorption capture, especially for metal–organic frameworks (MOFs) having high adsorption uptakes. Herein, a novel “self‐supporting foam” strategy is proposed to fabricate a thermally conductive MOFs@boron nitride nanosheets (BNNS) composite foam (MOFs@BNNS‐PEI) via polyethyleneimine (PEI) cross‐linkage. The “rebar” BNNS and the “aggregate” MOFs are packed against each other to form a self‐supporting structure, effectively reducing the reliance on polymers to maintain high MOFs loading. Furthermore, this approach enables the successful fabrication of three different types of typical MOFs, including HKUST‐1, MIL‐100(Fe), and ZIF‐8. This unique design maintains a high specific surface area (SSA) of the MOFs foam and generates nitrogen‐rich microporosity contributing to CO2 adsorption. Additionally, PEI serves as a thermal bridge to reduce the interfacial thermal resistance between BNNS and MOFs, accelerating the thermal desorption of CO2 within the MOFs foam. Benefiting from these advantages, the MOFs@BNNS‐PEI exhibits a higher CO2 adsorption capacity (1.35–1.42 times that of pure MOFs) and a significant increase in the desorption rate for CO2 (5.0–5.7 times that of pure MOFs). Thus, the thermally conductive MOFs foam can be a viable option for efficient CO2 capture in practical applications.
Synergistic Antimicrobial Glycyrrhizic Acid‐Based Functional Biosensing Composite for Sensitive Glucose Monitoring and Collaborative Wound Healing
Authors: Wang Xiao , Huo Haoling , Zhong Yanming , Yang Yingfei , Lin Huaijun , Cao Lin , Wang Qiwei , Xu Congjie , Lin Zhidan , Li Wei , Zhang Peng 
Published: April 2024

AbstractHigh glucose blood and bacterial infection remain major issues for the slow healing of diabetic wounds, so developing functional biosensing composite with excellent antibacterial and remarkable glucose response sensitivity is necessary and prospective. Herein, by in situ synthesis AgNPs on the surface of self‐prepared PTIGA elastomers, PTIGA‐AgNPs conductive composites are obtained with efficient synergistic antibacterial effect, excellent mechanical and self‐healing properties. The strain of the composites can reach 1800%, and its self‐healing efficiency exceeds 90% at 60 °C within 8 h. Both elastomers and composites represent excellent biocompatibility and the antibacterial rate against E. coli and S. aureus exceeded 90%. Moreover, the biosensor assembled from the conductive composites exhibits excellent glucose response sensitivity and stability, with a sensitivity coefficient of 0.518 mA mm−1 in the range of 0.2–3.6 × 10−3 m glucose concentration, as well as a low detection limit of 0.08 × 10−3 m. Furthermore, based on the remarkable antibacterial performance and bioactivity derived from GA, the composites reduce the expression of pro‐inflammatory factors and promote the production of anti‐inflammatory factors, and effectively promote the regeneration of skin and granulation tissue of wounds in a diabetic full‐thickness skin defect model, demonstrating the enormous therapeutic potential in diabetic wound healing.
An Electrode‐Crosstalk‐Suppressing Smart Polymer Electrolyte for High Safety Lithium‐Ion Batteries
Authors: Dong Tiantian , Xu Gaojie , Xie Bin , Liu Tao , Gong Tianyu , Sun Chenghao , Wang Jinzhi , Zhang Shu , Zhang Xiaohu , Zhang Huanrui , Huang Lang , Cui Guanglei 
Published: April 2024

AbstractElectrode crosstalk between anode and cathode at elevated temperatures is identified as a real culprit triggering the thermal runaway of lithium‐ion batteries. Herein, to address this challenge, a novel smart polymer electrolyte is prepared through in situ polymerization of methyl methacrylate and acrylic anhydride monomers within a succinonitrile‐based dual‐anion deep eutectic solvent. Owing to the abundant active unsaturated double bonds on the as‐obtained polymer matrix end, this smart polymer electrolyte can spontaneously form a dense crosslinked polymer network under elevated temperatures, effectively slowing down the crosstalk diffusion kinetics of lithium ions and active gases. Impressively, LiCoO2/graphite pouch cells employing this smart polymer electrolyte demonstrate no thermal runaway even at the temperature up to 250 °C via accelerating rate calorimeter testing. Meanwhile, because of its abundance of functional motifs, this smart polymer electrolyte can facilitate the formation of stable and thermally robust electrode/electrolyte interface on both electrodes, ensuring the long cycle life and high safety of LIBs. In specific, this smart polymer electrolyte endows 1.1 Ah LiCoO2/graphite pouch cell with a capacity retention of 96% after 398 cycles at 0.2 C.
Oxygen‐Mediated Surface Engineering of 3D Porous Graphene for All‐Graphene‐Based Humidity Sensors
Authors: Lee Eunji , Kwon Yeong Min , Bae Garam , Park Se Yeon , Song Da Som , Jo Hyeong‐ku , Lee Do Hyung , Jeon Hye Yoon , Kang Saewon , Yim Soonmin , Myung Sung , Lim Jongsun , Lee Sun Sook , Yoon Dae Ho , Song Wooseok 
Published: April 2024

AbstractReal‐world applications of graphene require reliable routes for synthesizing large‐area graphene and methods to tune its structural and electrical properties. A viable and facile route is presented for synthesizing 3D porous graphene (3PG) on PI films with tunable patterns and locations via the photon‐pen writing technique and subsequent oxygen plasma treatment. The laser power and scan speed are optimized for 3PG synthesis. The electrical properties and surface hydrophilicity are controlled via surface customization of 3PG with optimal oxygen plasma treatment duration and laser inter‐spacing. The capability of humidity sensors based on surface‐customized 3PG with hydrophobic surface is demonstrated.
Photochemical and Electrochemical Synthesis of Oxazoles and Isoxazoles: An Update
Authors: Ghosh Debashis , Sherin Ancy , Ghosh Sumit , Kalose Sushma A , Hajra Alakananda 
Published: April 2024

AbstractThis review presents an outline of current advancements in the photochemical and electrochemical synthesis of oxazoles and isoxazoles. Oxazole and isoxazole are important building blocks for a variety of medicinally useful compounds. Therefore, the synthesis of these heterocycles via sustainable technologies is worth demanding. Photochemical and electrochemical are two among the few sustainable technologies. This review covers a brief discussion on reaction parameters like catalysts, substrates scope, reaction temperature, solvents, electrodes, electrolytes (in case of electrochemical process), light source (in case of photochemical process) for individual reaction. Detailed discussion on mechanistic insight for each reaction is also presented. Finally, summary, and future direction toward the development of effective electrochemical and photochemical methods for the reaction of oxazoles and isoxazoles is also presented.
Sex‐specific scaling of leaf phosphorus vs. nitrogen under unequal reproductive requirements in Eurya japonica, a dioecious plant
Authors: He Dong , Liu Xiang‐Yu , Zheng Li‐Ting 
Published: April 2024

AbstractPremisePrevious work searching for sexual dimorphism has largely relied on the comparison of trait mean vectors between sexes in dioecious plants. Whether trait scaling (i.e., the ratio of proportional changes in covarying traits) differs between sexes, along with its functional significance, remains unclear.MethodsWe measured 10 vegetative traits pertaining to carbon, water, and nutrient economics across 337 individuals (157 males and 180 females) of the diocious species Eurya japonica during the fruiting season in eastern China. Piecewise structural equation modeling was employed to reveal the scaling relationships of multiple interacting traits, and multivariate analysis of (co)variance was conducted to test for intersexual differences.ResultsThere was no sexual dimorphism in terms of trait mean vectors across the 10 vegetative traits in E. japonica. Moreover, most relationships for covarying trait pairs (17 out of 19) exhibited common scaling slopes between sexes. However, the scaling slopes for leaf phosphorus (P) vs. nitrogen (N) differed between sexes, with 5.6‐ and 3.0‐fold increases of P coinciding with a 10‐fold increase of N in male and female plants, respectively.ConclusionsThe lower ratio of proportional changes in P vs. N for females likely reflects stronger P limitation for their vegetative growth, as they require greater P investments in fruiting. Therefore, P vs. N scaling can be a key avenue allowing for sex‐specific strategic optimization under unequal reproductive requirements. This study uncovers a hidden aspect of secondary sex character in dioecious plants, and highlights the use of trait scaling to understand sex‐defined economic strategies.
Comments on “Planar Tetracoordinate Hydrogen: Pushing the Limit of Multicentre Bonding”
Authors: Huo Bin , Zhang Xingyu , Lu Hai‐Gang , Jin Bo , Yuan Caixia , Meng Qingyong , Wu Yan‐Bo 
Published: April 2024

AbstractIn a recent communication (Angew. Chem. Int. Ed. 2024, 63, e202317312), Kalita et al. studied In4H+ system within the frame of single‐reference approximation (SRA) and found that the global energy minimum (1 a) adopted the singlet state and a planar tetracoordinate hydrogen (ptH), while the second lowest isomer (1 b) located 3.0 kcal/mol above 1 a and adopted the triplet state as well as non‐planar structure with a quasi‐ptH. They assessed the reliability of SRA by checking the T1‐diagnostic values of coupled cluster calculations. However, according to our multi‐configurational second‐order perturbation theory calculations at the CASPT2(12,13)/aug‐cc‐pVQZ (aug‐cc‐pVQZ‐PP for In) level, both 1 a and 1 b exhibit obvious multi‐referential characters, as reflected by their largest reference coefficients of 0.928 (86.1 %) and 0.938 (88.0 %), respectively. Moreover, 1 b is 5.05 kcal/mol lower than 1 a at this level, that is, what can be observed in In4H+ system is the quasi‐ptH.
Correlation of Professional Antigen‐Presenting Tbet+CD11c+ B Cells With Bone Destruction in Untreated Rheumatoid Arthritis
Authors: McGrath Sarah , Grimstad Kristoffer , Thorarinsdottir Katrin , Forslind Kristina , Glinatsi Daniel , Leu Agelii Monica , Aranburu Alaitz , Sundell Timothy , Jonsson Charlotte A. , Camponeschi Alessandro , Hultgård Ekwall Anna‐Karin , Tilevik Andreas , Gjertsson Inger , Mårtensson Inga‐Lill 
Published: April 2024

ObjectiveSubsets of CD21−/low memory B cells (MBCs), including double‐negative (DN, CD27−IgD−) and Tbet+CD11c+ cells, are expanded in chronic inflammatory diseases. In rheumatoid arthritis (RA), CD21−/low MBCs correlate with joint destruction. However, whether this is due to the Tbet+CD11c+ subset, its function and pathogenic contribution to RA are unknown. This study aims to investigate the association between CD21−/lowTbet+CD11c+ MBCs and joint destruction as well as other clinical parameters and to elucidate their functional properties in patients with untreated RA (uRA).MethodsClinical observations were combined with flow cytometry (n = 36) and single‐cell RNA sequencing (scRNA‐seq) and V(D)J sequencing (n = 4) of peripheral blood (PB) MBCs from patients with uRA. The transcriptome of circulating Tbet+CD11c+ MBCs was compared with scRNA‐seq data of synovial B cells. In vitro coculture of Tbet+CD11c+ B cells with T cells was used to assess costimulatory capacity.ResultsCD21−/lowTbet+CD11c+ MBCs in PB correlated with bone destruction but no other clinical parameters analyzed. The Tbet+CD11c+ MBCs have undergone clonal expansion and express somatically mutated V genes. Gene expression analysis of these cells identified a unique signature of more than 150 up‐regulated genes associated with antigen presentation functions, including B cell receptor activation and clathrin‐mediated antigen internalization; regulation of actin filaments, endosomes, and lysosomes; antigen processing, loading, presentation, and costimulation; a transcriptome mirrored in their synovial tissue counterparts. In vitro, Tbet+CD11c+ B cells induced retinoic acid receptor–related orphan nuclear receptor γT expression in CD4+ T cells, thereby polarizing to Th17 cells, a T cell subset critical for osteoclastogenesis and associated with bone destruction.ConclusionThis study suggests that Tbet+CD11c+ MBCs contribute to the pathogenesis of RA by promoting bone destruction through antigen presentation, T cell activation, and Th17 polarization.image
Waste‐to‐energy: the recycling and reuse of sugar industry waste for different value‐added products such as bioenegy in selected countries – a critical review
Authors: Gbadeyan Oluwatoyin Joseph , Sibiya Lindokuhle , Linganiso Linda Z , Deenadayalu Nirmala 
Published: April 2024

AbstractThe economies of several countries have benefited significantly from the sugarcane industry, as a result of investment in the industry, foreign exchange earnings, the generation of substantial employment, and connections with significant suppliers. Sugarcane industry participants have been forced to find ways to offset high operating costs due to industry pressures. Proper management of wastes generated from sugar production is essential to reduce the environmental burden of pollution. This study reviews physical, chemical, and biological procedures for reusing or recycling wastewater and other sugar industry waste for various applications. Different countries are continuing to invest in industrial sugar waste, for example biomass and wastewater, to generate renewable energy, but limited investment in the sugar industry in African countries has been identified. Some by‐products, including wastewater and filter cake, have been largely unused for the production of energy. The potential to generate bioenergy from sugarcane industry wastewater has been explored. Numerous technologies for obtaining energy from sugarcane wastewater are reviewed, including the reduction of energy needs through waste heat and process heat integration, generating biomass, combustion and gasification, anaerobic digestion for biogas, fermentation for bioethanol, and the direct production of electricity using microbial fuel cells. Reusing and recycling the sugar industry's waste would increase profits, create more job opportunities, and help to boost the global economy.
Effects of down‐regulated carbonic anhydrase 8 on cell survival and glucose metabolism in human colorectal cancer cell lines
Authors: Wu Cheng‐Yen , Yu Jia‐Yo , Chen Yi‐Shan , Chang Hui‐Ping , Hsieh Benjamin Y. , Lin Yu‐Hsin , Ma Chung‐Yung , Tsai Shang‐Feng , Hsieh Mingli 
Published: April 2024

AbstractCarbonic anhydrase 8 (CA8) is a member of the α‐carbonic anhydrase family but does not catalyze the reversible hydration of carbon dioxide. In the present study, we examined the effects of CA8 on two human colon cancer cell lines, SW480 and SW620, by suppressing CA8 expression through shRNA knockdown. Our results showed that knockdown of CA8 decreased cell growth and cell mobility in SW620 cells, but not in SW480 cells. In addition, downregulated CA8 resulted in a significant decrease of glucose uptake in both SW480 and SW620 cells. Interestingly, stable downregulation of CA8 decreased phosphofructokinase‐1 expression but increased glucose transporter 3 (GLUT3) levels in SW620 cells. However, transient downregulation of CA8 fails to up‐regulate GLUT3 expression, indicating that the increased GLUT3 observed in SW620‐shCA8 cells is a compensatory effect. In addition, the interaction between CA8 and GLUT3 was evidenced by pull‐down and IP assays. On the other hand, we showed that metformin, a first‐line drug for type II diabetes patients, significantly inhibited cell migration of SW620 cells, depending on the expressions of CA8 and focal adhesion kinase. Taken together, our data demonstrate that when compared to primary colon cancer SW480 cells, metastatic colon cancer SW620 cells respond differently to downregulated CA8, indicating that CA8 in more aggressive cancer cells may play a more important role in controlling cell survival and metformin response. CA8 may affect glucose metabolism‐ and cell invasion‐related molecules in colon cancer, suggesting that CA8 may be a potential target in future cancer therapy.
In Silico Study of the Early Stages of Aggregation of β‐Sheet Forming Antimicrobial Peptide GL13K
Authors: Hamidabad Mohammadreza Niknam , Watson Natalya A. , Wright Lindsay N. , Mansbach R. A. 
Published: April 2024

AbstractAntimicrobial peptides (AMPs) are of growing interest as potential candidates that may offer more resilience against antimicrobial resistance than traditional antibiotic agents. In this article, we perform the first in silico study of the synthetic ß sheet‐forming AMP GL13K. Through atomistic simulations of single and multi‐peptide systems under different conditions, we are able to shine a light on the short timescales of early aggregation. We find that isolated peptide conformations are primarily dictated by sequence rather than charge, whereas changing charge has a significant impact on the conformational free energy landscape of multi‐peptide systems. We demonstrate that the loss of charge‐charge repulsion is a sufficient minimal model for experimentally observed aggregation. Overall, our work explores the molecular biophysical underpinnings of the first stages of aggregation of a unique AMP, laying necessary groundwork for its further development as an antibiotic candidate.
A rare case of Gardner syndrome in an African adult male: A case report
Authors: Olaopa Olusegun I. , Dada Adedamola A. , Soneye Oluwafunmilayo Y. , Iyapo Oluwadamilare , Akinniyi Taofeek A. , Adisa Akinyele O. , Kanmodi Kehinde K. , Olaopa Adedolapo O. , Emeka Christian I. , Ehanire Imudia D. , Coker Modupe O. 
Published: April 2024

Key Clinical MessageGardner's syndrome with the complete manifestation of colonic and extracolonic features is uncommon. Therefore, every clinician should view extracolonic features with a high index of suspicion. This may be key to early diagnosis, definitive management in these patients and importantly, helps prevent malignant transformation of existing colonic polyps.
Performance of Photovoltaic Thermal and Biomass Gasification for Efficient Renewable Energy Generation: A Review
Authors: Kamaruzaman Nursyuhada’ , Mohd Shadzalli Zahrul Faizi , Abdul Manaf Norhuda , Allouzi Mintallah Mousa A. , Thangalazhy‐Gopakumar Suchithra 
Published: April 2024

AbstractThis review presents the technical and operational performances of solar and biomass energy technologies viz photovoltaic thermal (PVT) and biomass gasification systems. This work aims to offer a reference and guidelines to the renewable energy‐related players, especially for those at the operational level and investors. This paper highlights the technical advantage of hybrid PVT with phase change material in terms of electrical and thermal efficiencies. While the operational performance of biomass gasification is thoroughly discussed via sensitivity analysis, the potential integration between solar and biomass gasification technologies is explored to complement and bolster the capabilities of both renewable systems within the power energy mix portfolio. Finally, few directions and significant takeaways considering the technical criteria are addressed for identifying efficient renewable energy generation.
Decoding Voltammograms at the Molecular Frontier: Integration of Voltammetry and Mass Spectrometry
Authors: Koovakattil Surendran Adarsh , Roithová Jana 
Published: April 2024

AbstractElectrochemical reactions are better understood by gaining insight into the molecular transformations at the electrodes. This paper introduces a straightforward experimental arrangement in which the voltammetry experiment in a standard electrochemical cell integrates with online electrospray‐ionization mass‐spectrometry. The procedure allows for monitoring of the ions produced at the working electrode. The ionic species sampling is facilitated by a silica capillary embedded in the working electrode and connected directly to the electrospray ionization source. This integration configures real‐time monitoring of the ions produced at the working electrode, enhancing our knowledge of the electrochemical process. The methodology is thoroughly described and exemplified by monitoring the reactive intermediates and products that arise during the electrochemical oxidation of carbazole. This design provides an opportunity to study intermediates in electrochemical reactions with advanced mass spectrometry methods such as ion mobility separation or ion spectroscopy.
Impacts of immune microenvironment on musculoskeletal health
Authors: Xu Ren 
Published: April 2024

AbstractUnderstanding the interplay between immune cells and the bone marrow microenvironment is crucial for elucidating age‐related musculoskeletal changes. In this commentary manuscript, we summarized that studies have shown that proinflammatory immune cells in the bone marrow, such as macrophages and neutrophils, can inhibit bone formation by secreting grancalcin. Research on skeletal stem cells (SSCs) in aged mice reveals a shift towards pro‐inflammatory gene expression, affecting their osteogenic potential, while another study maps age‐related changes in cranial SSC niches, emphasizing the role of the CXCL12–CXCR4 axis in stem cell‐immune cell communication, Additionally, the immune system influences hematopoietic stem cells (HSCs); Niche ageing and accumulation of mutations with age lead to HSC exhaustion and a bias towards myeloid differentiation, with toll‐like receptors playing a key role in maintaining hematopoiesis and bone metabolism balance.
Treatment effects of empagliflozin in hospitalized heart failure patients across the range of left ventricular ejection fraction – Results from the EMPULSE trial
Authors: Tromp Jasper , Kosiborod Mikhail N. , Angermann Christiane E. , Collins Sean P. , Teerlink John R. , Ponikowski Piotr , Biegus Jan , Ferreira João Pedro , Nassif Michael E. , Psotka Mitchell A. , Brueckmann Martina , Blatchford Jonathan P , Steubl Dominik , Voors Adriaan A. 
Published: April 2024

AbstractAimThe EMPULSE (EMPagliflozin in patients hospitalised with acUte heart faiLure who have been StabilizEd) trial showed that, compared to placebo, the sodium–glucose cotransporter 2 inhibitor empagliflozin (10 mg/day) improved clinical outcomes of patients hospitalized for acute heart failure (HF). We investigated whether efficacy and safety of empagliflozin were consistent across the spectrum of left ventricular ejection fraction (LVEF).Methods and resultsA total of 530 patients hospitalized for acute de novo or decompensated HF were included irrespective of LVEF. For the present analysis, patients were classified as HF with reduced (HFrEF, LVEF ≤40%), mildly reduced (HFmrEF, LVEF 41–49%) or preserved (HFpEF, LVEF ≥50%) ejection fraction at baseline. The primary endpoint was a hierarchical outcome of death, worsening HF events (HFE) and quality of life over 90 days, assessed by the win ratio. Secondary endpoints included individual components of the primary endpoint and safety. Out of 523 patients with baseline data, 354 (67.7%) had HFrEF, 54 (10.3%) had HFmrEF and 115 (22.0%) had HFpEF. The clinical benefit (hierarchical composite of all‐cause death, HFE and Kansas City Cardiomyopathy Questionnaire total symptom score) of empagliflozin at 90 days compared to placebo was consistent across LVEF categories (≤40%: win ratio 1.35 [95% confidence interval 1.04, 1.75]; 41–49%: win ratio 1.25 [0.66, 2.37)] and ≥50%: win ratio 1.40 [0.87, 2.23], pinteraction = 0.96) with a favourable safety profile. Results were consistent across individual components of the hierarchical primary endpoint.ConclusionThe clinical benefit of empagliflozin proved consistent across LVEF categories in the EMPULSE trial. These results support early in‐hospital initiation of empagliflozin regardless of LVEF.