bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circadian Pattern in Restless Legs Syndrome: Implications for Treatment Posology
Authors: Garcia-Malo Celia , Cano-Pumarega Irene , Castro-Villacañas-Farzamnia Andrea , Boi Sara 
Published: April 2024

AbstractThe symptoms of restless legs syndrome (RLS) follow a circadian pattern, as inducated in the current RLS diagnostic criteria. Indeed, subjects with mild-to-moderate RLS suffer or not from RLS symptoms depending on the time of day, resembling an above-threshold state periodically followed by a below-threshold state. Although the circadian clock is crucial in the clinical features of RLS, research assessing the ultimate drivers of circadian rhythmicity is still very limited. In the present review, we show current evidence on circadian variations of neurotransmitters involved in the pathophysiology of RLS (systemic iron metabolism, brain iron homeostasis, adenosine, dopamine, glutamate, and endogenous opioids). Secondly, an overview of available therapies for RLS is presented, including information on current recommendations for symptomatic treatments in RLS.We discuss the importance of further research into the circadian oscillations that occur in RLS, so that they can be managed, and a protective below-threshold state can be established on an individualized basis. In addition, we also discuss the current dosing of the medications prescribed in RLS symptomatic treatments, and how circadian factors should be considered to better adjust dosing on an individualized basis and increase the therapeutic benefit.
Therapeutic Response to PRRNT in a Rare Case of Metastatic Renal Neuroendocrine Carcinoma
Authors: Sunny Saumya Sara , Hephzibah Julie , Chacko Raju Titus , Kodiatte Thomas Alex 
Published: April 2024

AbstractNeuroendocrine tumors (NETs) are a rare spectrum of neoplasms that are characterized by neuroendocrine and neural differentiation. The treatment can be challenging in view of the heterogeneity in differentiation and behavior. Primary renal origin NETs are rare and only a few cases have been reported in the literature. There is limited knowledge on their presentation and response to various lines of treatment. We report a case of a patient with a metastatic renal NET from a rare histological subtype of large cell neuroendocrine carcinoma, known to cause aggressive disease with poor prognosis. A multimodality treatment approach was followed. In spite of surgical management and second-line chemotherapy, the disease progressed. The patient subsequently received peptide receptor radionuclide therapy (PRRNT) using lutetium-177 DOTATATE, following which the patient demonstrated a remarkable clinical and radiological response and is stable to date. In a rare tumor with poor prognosis, the relevance of theranostics and the efficacy of targeted therapies like PRRNT are noteworthy.
Plasmonic couplings in Ag–Au heterodimers
Authors: Gomrok Saghar , Eldridge Brinton King , Chaffin Elise A. , Barr James W. , Huang Xiaohua , Hoang Thang B. , Wang Yongmei 
Published: April 2024

The plasmonic coupling between silver (Ag) and gold (Au) nanoparticles (NPs) under four polarization modes was examined: a longitudinal mode (L-mode), where the electric field of a linearly polarized incident light parallels the dimer axis, and three transverse modes (T-modes), where the electric field of the light is perpendicular to the dimer axis. The coupling was studied using the discrete dipole approximation followed by an in-house postprocessing code that determines the extinction (Qext), absorption (Qabs), and near-field (Qnf) spectra from the individual NPs as well as the whole system. In agreement with the literature results, the extinction/absorption spectra of the whole dimer have two peaks, one near the Ag localized surface plasmon resonance (LSPR) region and the other at the Au LSPR region, with the peak at Ag LSPR being reduced in all modes and the peak at Au LSPR being red-shifted and increased in the L-mode but not in the T-modes. It is further shown that the scattering at the Ag LSPR region is reduced and becomes less than the isolated Ag NPs, but the absorption at the Ag LSPR is increased and becomes greater than the isolated Ag NPs for the 50 nm Ag–Au heterodimer. This suggests that the scattering from Ag NPs is being reabsorbed by the neighboring Au NPs due to the interband electronic transition in Au at that wavelength range. The Qext from the individual NP in the heterodimer shows the presence of the Fano profile on the Au NP but not on the Ag NP. This phenomenon was further investigated by using a dielectric particle (DP) placed near the Ag or Au NPs. The Fano profile appears in the absorbing DP spectra placed near either Ag or Au NPs. However, the Fano profile is masked upon further increases in the refractive index value of the DP particle. This explains the absence of a Fano profile on the Ag NPs in the Ag–Au heterodimer. The large near-field enhancement on both Ag and Au NPs at the Au plasmonic wavelength in the L-mode for large NPs was investigated through a DP-Au system. The large enhancement was shown to arise from a large imaginary component of the DP refractive index and a small real component. Through examination of both the near- and far-field properties of the individual NPs as well as the whole system and examinations of DP-Ag and DP-Au systems, our study provides a new understanding of the couplings between Ag and Au NPs.
Reduction of mechanical losses in ion-beam sputtered tantalum oxide thin films via partial crystallization
Authors: Favaro Giulio , Milotti Valeria , Alonso Diaz Riega Diego , Busdon Nicole , Bazzan Marco , Granata Massimo , Hofman David , Michel Christophe , Pinard Laurent , Conti Livia , Capaccioli Simone , Shcheblanov Nikita S , Lemaître Anaël , Martinez Valérie , Cagnoli Gianpietro , Piergiovanni Francesco , Fabrizi Federica , Pelizzo Maria G , Corso Alain J 
Published: April 2024

Abstract
This study explores the impact of crystalline fraction on the mechanical losses of amorphous tantalum oxide (tantala, Ta2O5) thin films intended for gravitational wave detectors. We use ion beam sputtering technique to prepare a series of samples, which are then subjected to controlled thermal annealing to achieve varying degrees of crystallized fraction. The microscopic structure of the annealed samples is characterized by combining different analytical techniques. Our investigation reveals that the amorphous films comprise randomly distributed crystalline grains, whose density and average size depends on the duration of thermal treatment. To assess mechanical losses of the coatings, a gentle nodal suspension system is applied. Remarkably, a substantial reduction of approximately 20% in the coating’s mechanical loss angle with respect to annealed amorphous coatings is observed for samples exhibiting a crystalline fraction of around 5%. This improvement may lead to the definition of alternative thermal treatments to improve the mechanical performances of coatings for gravitational wave detectors or other highly sensitive optical experiments. However the reduction in mechanical losses comes at the expense of an increase in optical scattering. The possibility of reducing the optical losses to the level required by gravitational interferometers by modifying the grain size distribution via appropriate annealing treatments is discussed.
Optical properties of germania and titania at 1064 nm and at 1550 nm
Authors: Diksha D , Amato A , Spagnuolo V , McGhee G I , Chicoine M , Clark C , Hill S , Hough J , Johnston R , Keil R , Mavridi N , Reid S , Rowan S , Schapals T , Schiettekatte F , Tait S C , Martin I W , Steinlechner J 
Published: April 2024

Abstract
One of the main noise sources in current gravitational-wave detectors is the thermal noise of the high-reflectivity coatings on the main interferometer optics. Coating thermal noise is dominated by the mechanical loss of the high-refractive index material within the coating stacks,

Ta
2

O
5

mixed with

TiO
2

. For upgrades to room-temperature detectors, a mixture of

GeO
2

and

TiO
2

is an interesting alternative candidate coating material. While the rather low refractive index of GeO2 increases with increasing

TiO
2

content, a higher

TiO
2

content results in a lower threshold temperature before heat treatment leads to crystallisation, and potentially to a degradation of optical properties. For future cryogenic detectors, on the other hand, a higher

TiO
2

content is beneficial as the TiO2 suppresses the low-temperature mechanical loss peak of GeO2. In this paper, we present the optical properties of coatings—produced by plasma-assisted ion-beam evaporation—with high TiO2 content at 1550 nm, a laser wavelength considered for cryogenic gravitational-wave detectors, as a function of heat-treatment temperature. For comparison, the absorption of pure GeO2 was also measured. Furthermore, results at the currently-used wavelength of 1064 nm are presented.
Crossed Andreev reflection in normal-superconductor-normal junction based on Kekulé-Y patterned graphene
Authors: Li Xue-Si , Liu Dong-Yan , Jin Zhao , He Chun-Lin 
Published: April 2024

Abstract
We theoretically study the crossed Andreev reflection (CAR) of the normal metal-superconductor-normal metal (NSN) heterojunction based on Kekulé-Y patterned graphene with two doping types, i.e. nSn and nSp configurations. It is found that the enhanced CAR is more likely to occur in the nSp junction rather than the nSn junction. To be concrete, the almost perfect CAR occurs in a large range of incident angle in the single Dirac cone phase when the incident energy is inside the gap of the nonlinear band. Furthermore, the roles of the length of superconductor and pseudospin-valley coupling on conductance are also evaluated.
A CGLS-based method for solving magnetic moments of hybrid-model magnetic targets
Authors: Lu Binjie , Zhang Xiaobing , Dai Zhonghua 
Published: April 2024

Abstract
In order to solve the problem of magnetic moment estimation of magnetic targets, the inverse problem of magnetic moment estimation was constructed based on the hybrid model of ellipsoid and magnetic dipole array. In order to solve the ill-posed problem of the magnetic moment estimation equations, the method was designed to estimate the magnetic moment parameters of the ellipsoid and magnetic dipole array, and the improved discrepancy principle and the maximum chi-square distribution stop criterion were introduced to improve the semi-convergence behavior of the conjugate gradient least squares (CGLS) method. Through simulation examples of magnetic target magnetic moment estimation and ship model measurement data, the performance of two CGLS methods, Tikhonov algorithm and stepwise regression method, were compared and analyzed from four aspects: relative error of magnetic moment estimation, relative error of magnetic field fitting, relative error of magnetic field extrapolation, and computational time complexity. The CGLS method has the advantages of high accuracy of magnetic moment estimation, high immunity of magnetic moment estimation to interference, high accuracy of magnetic field fitting and extrapolation, and low computational time complexity.
Measuring the profile of aircraft engine blades using spectral confocal sensors
Authors: Chen Ze , Xue Kaiyan , Sun Chuanzhi , Liu Yongmeng , Tan Jiubin 
Published: April 2024

Abstract
The geometric parameters of aircraft engine blades need to be precisely measured to ensure the quality of the blades for the normal operation of aircraft engines. This study aims to address the challenges of existing measurement systems in balancing efficiency, accuracy, and completeness. Additionally, it aims to enhance the accuracy and robustness of the algorithm for extracting blade profile characteristic parameters. In this paper, a spectral confocal sensor is employed to establish a blade profile measurement system. The design includes a probe sampling strategy, and a standard ball is used to calibrate the sensor probe’s light emission direction and the precise rotation center of the turntable. The paper proposes the use of methods such as partition search algorithm, binary search, and curvature segmentation to process point cloud data of blade body and tenon. We have conducted experimental measurements on the blades of an aircraft engine. The acquired three-dimensional point cloud data of multiple sets of blade cross-sections and dovetail sections were processed. After calculation, the maximum measurement errors for chord length, maximum blade thickness, tenon width, bottom height, top angle, and bottom angle are −0.0036 mm, −0.00721 mm, −0.0102 mm, −0.00928 mm, 0.0086°, and −0.0058°, respectively. This process validates the effectiveness of the proposed method and has high measurement accuracy. Compared with the CMM method, this method is more accurate in measuring small pits and large curvature micro surfaces, with higher measurement integrity and higher measurement efficiency.
Structure-led manifestation of photocatalytic activity in magnetically recoverable spinel CuFe2O4 nanoparticles and its application in degradation of industrial effluent dyes under solar light
Authors: Zala Devanshi , Mishra Atul K , Mukhopadhyay Indrajit , Ray Abhijit 
Published: April 2024

Abstract
An efficient removal of the photocatalysts used in the decontamination of water is crucial after its application beside its expected visible light sensitive activities. This study presents the synthesis of magnetically separable CuFe2O4 nanoparticles (CFNPs) with enhanced photoactivity under AM 1.5 G sunlight. A simple two-step process involving co-precipitation and hydrothermal treatment is employed, with subsequent annealing at temperatures from 200 °C to 1000 °C to synthesize the CFNPs. The characteristic features of the highest photoactive tetragonal phase of CFNP are confirmed by powder XRD studies with Rietveld refinement. This scheme strategically controls the growth of a highly photoactive tetragonal phase with predominant (224) facets over other less active facets in cubic CuFe2O4. Mott–Schottky analysis confirms the p-type semiconducting nature of CFNPs. A favourable direct optical band gap of 1.73 eV, as well as photoluminescence emission quenching for visible photons, show that the (224) oriented CFNPs are good photocatalysts in the visible spectrum with demonstrated organic dye degradations, including methylene blue and others. A density functional theory-based approach validates that the adsorption of such dye is thermodynamically more favourable on (224) facets of CuFe2O4 to facilitate the redox action by the excitons.
Robust ZTO-reinforced Ag nanowire hybrid transparent conductive thin films with absorption-enhanced electromagnetic interference shielding property
Authors: Jenifer K , Parthiban S 
Published: April 2024

Abstract
Technological advances have accelerated the pursuit of transparent conducting thin films (TCFs) with superior mechanical properties, durability, efficient optoelectrical performance and substrate compatibility as a pivotal focus in the realm of flexible transparent electronics. Against this background, this work investigates the fabrication of multilayer silver nanowire (AgNW) thin films reinforced by zinc tin oxide (ZTO) thin film encapsulation on polycarbonate substrates by a combination of sputtering and spin-coating techniques. An investigation of the influence of AgNW percolation networks on the optoelectrical properties of ZTO/AgNW/ZTO hybrid thin films was carried out. The impact of ZTO protective layers on the enhancement of electrical properties, adhesivity, flexibility and environmental stability of the multilayer TCF was elucidated. Additionally, to explore the compatibility of the fabricated TCF in integrated device and stealth applications, its electromagnetic interference shielding properties were investigated. The hybrid TCF showed 99.47% EMI shielding efficiency with an absorption-dominant EMI shielding effectiveness of 22.7 dB in the x-band region.
Melanin-Ce6-loaded polydopamine nanoparticles-based enhanced phototherapy for B16 melanoma cancer cells
Authors: Shinde Vinod Ravasaheb , Thanekar Ajinkya Madhukar , Khatun Sajmina , Buddhiraju Hima Sree , Bhattacharjee Basu , Rengan Aravind Kumar 
Published: April 2024

Abstract
Melanoma is one of the most aggressive and lethal types of cancer owing to its metastatic propensity and chemoresistance property. An alternative therapeutic option is photodynamic and photothermal therapies (PDT/PTT), which employ near-infrared (NIR) light to generate heat and reactive oxygen species (ROS). As per previous reports, Melanin (Mel), and its synthetic analogs (i.e. polydopamine nanoparticles) can induce NIR light-mediated heat energy, thereby selectively targeting and ameliorating cancer cells. Similarly, chlorin e6 (Ce6) also has high ROS generation ability and antitumor activity against various types of cancer. Based on this tenet, In the current study, we have encapsulated Mel-Ce6 in a polydopamine (PDA) nanocarrier (MCP NPs) synthesized by the oxidation polymerization method. The hydrodynamic diameter of the synthesized spherical MCP NPs was 139 ± 10 nm. The MCP NPs, upon irradiation with NIR 690 nm laser for 6 min, showed photothermal efficacy of more than 50 °C. Moreover, the red fluorescence in the MCP NPs due to Ce6 can be leveraged for diagnostic purposes. Further, the MCP NPs exhibited considerable biocompatibility with the L929 cell line and exerted nearly 70% ROS-mediated cytotoxicity on the B16 melanoma cell line after the laser irradiation. Thus, the prepared MCP NPs could be a promising theranostic agent for treating the B16 melanoma cancer.
Multi-scale feature aggregation and fusion network with self-supervised multi-level perceptual loss for textures preserving low-dose CT denoising
Authors: Zhang Yuanke , Wan Zhaocui , Wang Dong , Meng Jing , Ma Fei , Guo Yanfei , Liu Jianlei , Li Guangshun , Liu Yang 
Published: April 2024

Abstract

Objective. The textures and detailed structures in computed tomography (CT) images are highly desirable for clinical diagnosis. This study aims to expand the current body of work on textures and details preserving convolutional neural networks for low-dose CT (LDCT) image denoising task. Approach. This study proposed a novel multi-scale feature aggregation and fusion network (MFAF-net) for LDCT image denoising. Specifically, we proposed a multi-scale residual feature aggregation module to characterize multi-scale structural information in CT images, which captures regional-specific inter-scale variations using learned weights. We further proposed a cross-level feature fusion module to integrate cross-level features, which adaptively weights the contributions of features from encoder to decoder by using a spatial pyramid attention mechanism. Moreover, we proposed a self-supervised multi-level perceptual loss module to generate multi-level auxiliary perceptual supervision for recovery of salient textures and structures of tissues and lesions in CT images, which takes advantage of abundant semantic information at various levels. We introduced parameters for the perceptual loss to adaptively weight the contributions of auxiliary features of different levels and we also introduced an automatic parameter tuning strategy for these parameters. Main results. Extensive experimental studies were performed to validate the effectiveness of the proposed method. Experimental results demonstrate that the proposed method can achieve better performance on both fine textures preservation and noise suppression for CT image denoising task compared with other competitive convolutional neural network (CNN) based methods. Significance. The proposed MFAF-net takes advantage of multi-scale receptive fields, cross-level features integration and self-supervised multi-level perceptual loss, enabling more effective recovering of fine textures and detailed structures of tissues and lesions in CT images.
Compressive properties of a modified re-entrant chiral auxetic structure (MRCA) under uniaxial quasi-static loading
Authors: Alomarah Amer , Hamdoon Farouk Omar , Al-Ibraheemi Zahraa A , Ruan Dong 
Published: April 2024

Abstract
Auxetics are a unique class of innovative materials/structures. Auxetic material/structures possess a negative value of Poisson’s ratio owing to the distinguished deformation behavior represented by the transvers expansion or contraction when they experience uniaxial stretching or compression, respectively. The aim of this manuscript is to show contributions of the structural modification on an auxetic hybrid structure. The in-plane properties of an auxetic structure, called the modified re-entrant chiral auxetic (MRCA) structure under quasi-static compression were experimentally and numerically explored. The experimental specimens were 3D printed using fused deposition modeling technique. The commercial ABAQUS/Explicit solver was used to develop the simulated models. Results showed that the structural modification have led to effectively improve deformation coordination (i.e. uniform deformation patterns) and the compressive properties of the modified structure. Young’s moduli were 1.75 and 12.7 higher than those of the original geometry, while values of plateau stress were 3.1 and 1.23 higher than those of the original geometry when they were compressed along the X and Y axes, respectively. The specific energy absorptions per unit mass were 4.7 J g−1 and 3.9 J g−1 when the MRCA specimens were compressed along the X and Y axes, respectively. However, the added cylinders limited the auxeticity (i.e. the transvers contraction) of the specimens during the compression tests.
Improving photon number resolvability of a superconducting nanowire single-photon detector array using a level comparator circuit
Authors: Huang Jia , Zhang Xingyu , Zhang Weijun , Wang Yong , Lv Chaolin , Xu Guangzhao , Liu Xiaoyu , Li Hao , Wang Zhen , You Lixing 
Published: April 2024

Abstract
Photon number resolving (PNR) capability is very important in many optical applications, including quantum information processing, fluorescence detection, and few-photon-level ranging and imaging. Superconducting nanowire single-photon detectors (SNSPDs) with a multipixel interleaved architecture give the array an excellent spatial PNR capability. However, the signal-to-noise ratio (SNR) of the PNR (SNRPNR) of the array will be degraded with increasing the element number due to the electronic noise in the readout circuit, which limits the PNR resolution as well as the maximum PNR number. In this study, a 16-element interleaved SNSPD array was fabricated, and the PNR capability of the array was investigated and analyzed. By introducing a level comparator circuit (LCC), the SNRPNR of the detector array was improved over a factor of four. In addition, we performed a statistical analysis of the photon number on this SNSPD array with LCC, showing that the LCC method effectively enhances the PNR resolution. Besides, the system timing jitter of the detector was reduced from 90 ps to 72 ps due to the improved electrical SNR.
Superposition principle with Ampère’s law and a semi-infinite wire
Authors: Kanchanapusakit Wittaya , Tanalikhit Pattarapon 
Published: April 2024

Abstract
In this article, a semi-infinite wire serves as a pedagogical example to demonstrate Ampère’s law. To effectively apply the law, two conditions must be met: (i) the wire must form a closed circuit, and (ii) the current must have symmetry. Fulfilling requirement (i) involves connecting an additional semi-infinite wire at an arbitrary angle, ensuring that their far ends join at infinity to form a closed circuit. Although this additional wire disrupts current symmetry, condition (ii) can be satisfied by superposing multiple diagrams wherein the additional wires are arranged with symmetry. Ampère’s law can then be utilized to determine the magnetic field generated by the wire arrangement. The analysis in this article is well-suited for introductory electromagnetism courses, highlighting the principle of superposition in physics.