bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of Life of Adults with Growth Hormone Deficiency: a Controlled Study
Authors: BJORK S. , JONSSON B. , WESTPHAL O. , LEVIN J.‐E. 
Published: January 2008

ABSTRACTBjörk, S., Jönsson, B., Westphal, 0. and Levin, J.‐E. (Center for Medical Technology Assessment, Linkoping University, and the Department of Paediatrics II, University of Gothenburg, Sweden). Quality of life of adults with growth hormone deficiency: a controlled study. Acta Paediatr Scand [Suppl] 356: 55, 1989.The quality of life of 23 adults with growth hormone deficiency (GHD) who had received growth hormone (GH) therapy was compared with that of 47 normal individuals in a control group. The GHD group had a poorer quality of life than the control group. Statistically significant differences were found between the groups for social isolation, physical mobility, sleep, and emotional status. More individuals in the control group had a driving licence and were married than in the GHD group.
Quality of Life Assessment Before and After Growth Hormone Treatment in Adults with Growth Hormone Deficiency
Authors: McGAULEY G.A. 
Published: January 2008

ABSTRACTMcGauley, G.A. (Department of Medicine, United Medical and Dental Schools of Guy's and St Thomas's Hospitals, St Thomas's Hospital, London, UK). Quality of life assessment before and after growth hormone treatment in adults with growth hormone deficiency. Acta Paediatr Scand [Suppl] 356: 70, 1989.The effect of recombinant human growth hormone (rhGH) treatment on the quality of life w'as studied in adults with growth hormone deficiency (GHD). Twenty‐four adults who satisfied strict criteria for GHD took part in a double‐blind, placebo‐controlled, 6‐month trial.‘Quality of life’assessment was performed at entry into the trial and after 1 month and 6 months, by means of self‐rating questionnaires. Entry data were also compared with a control group of healthy subjects matched for age, gender, ethnic origin, socio‐economic class and area of residence. Significantly lower scores on‘quality of life’assessment in the growth hormone (GH) deficient patients were reported at entry into the trial compared with matched controls, indicating that patients with GHD may be psychologically compromised. Preliminary analysis of the results shows that after 6 months patients receiving human growth hormone (hGH) treatment experienced less perceived illness than the placebo group. Significant psychological improvement was noted in the hGH‐treated patients’perception of their energy level and mood compared to the placebo group.
Effect of PaCO2 and Haemoglobin Concentration on Day to Day Variation of CBF in Preterm Neonates
Authors: PRYDS O. , GREISEN G. 
Published: January 2008

ABSTRACTPryds, O. and Greisen, G. (Department of Neonatology, Rigshospitalet, Copenhagen, Denmark). Effect of PaCO2 and haemoglobin concentration on day to day variation of CBF in preterm neonates. Acta Paediatr Scand, Suppl 360: 33, 1989.The CBF was measured on the first three days of life in 22 mechanically ventilated, preterm neonates (mean gestational age 29.5 weeks) with simultaneous recordings of arterial carbon dioxide tension (PaCO2), arterial oxygen tension (PaO2), haemoglobin concentration (Hgb), haemoglobin oxygen saturation and mean arterial blood pressure (MABP). CBF ± tended to increase slightly with age. The intra‐individual variation of CBF ± was positively related to changes in PaCO2 (p=0.0004) and inversely related to changes in Hgb (p=0.029). Neither PaO2 nor MABP achieved a significant relation to changes in CBF ± Thus, the mean CBF ±‐CO2 reactivity was calculated to 22.1 % per kPa whereas CBF increased by a mean of 11.9% per mM decrease of Hgb thereby providing a constant oxygen delivery to the brain. It is concluded that PaCO2 and Hgb have the expected effect on CBF ± in preterm neonates even during respiratory distress shortly after birth.
Perinatal Growth Retardation in Preterm Infants
Authors: GREISEN GORM , PETERSEN MINNA BLOCH 
Published: January 2008

ABSTRACTGreisen, G. and Petersen, M. B. (Department of Neonatology, Rigshospitalet, Copenhagen, Denmark). Perinatal growth retardation in preterm infants. Acta Paediatr Scand Suppl 360: 43, 1989.Perinatal and 4‐year follow‐up data were analysed for 137 children born after 26 to 35 weeks of gestation. All were free of severe prenatal or neonatal illness and of major handicaps. Infants who were light‐for‐gestation at birth were approximately 0.6 SDS smaller at 4 years than the appropriate‐for‐gestation infants as regards height, weight, and head circumference (p< 0.005). The McCarthy general cognitive score was reduced (p = 0.03). Motor scores, standardised for cognitive function, were also reduced (p = 0.02) indicating that motor—perhaps cerebellar—function is particularly vulnerable to perinatal growth retardation.
Neonatal Septicaemia—Incidence, Etiology and Outcome A 6‐year Analysis
Authors: GRAUEL E. L. , HALLE E. , BOLLMANN R. , BUCHHOLZ P. , BUTTENBERG S. 
Published: January 2008

ABSTRACTGrauel, E. L., Halle, E., Bollmann, R., Buchholz, P. and Buttenberg, S. (Department of Neonatology, Pediatric Clinic and Institute of Medical Microbiology, University‐Hospital (Charité), Berlin, GDR). Neonatal septicaemia—incidence, etiology and outcome. A 6‐year analysis. Acta Paediatr Scand Suppl 360: 113, 1989.Between 1983 and 1988 we observed altogether 222 cases of neonatal septicemia and/or meningitis in our Department of Neonatology. The incidence was 8.46 per 1000 liveborn infants. The case fatality rate amounted to 45.9 Yo. The most frequently isolated causative agents were Escherichia coli (23,4 %) followed by group B Streptococci (16.7%), Staphylococcus aureus (9.9%), Klebsiella pneumoniae species (8.8%), Serratia marcescens (7.9 %), Pseudomonas aeruginosa and coagulase‐negative Staphy‐lococci each 5.9%. The report includes information about serotypes of Escherichia coli, group B Streptococci and plasmid patterns of Serratia marcescens. The latter was responsible for an outbreak of septicemia and meningitis with high mortality. The changing infection pattern reflects changes in the newborn population, especially in the patient structure of the neonatal intensive care unit, changes in the antibiotic policy and organizational problems.
Physiological Growth Hormone Secretion and Response to Growth Hormone Treatment in Children with Short Stature and Intrauterine Growth Retardation
Authors: STANHOPE R. , ACKLAND F. , HAMILL G. , CLAYTON J. , JONES J. , PREECE M.A. 
Published: January 2008

ABSTRACT.Stanhope, R., Ackland, F., Hamill, G., Clayton, J., Jones, J. and Preece, M.A. (Department of Growth and Development, Institute of Child Health, London and Serono Laboratories, UK). Physiological growth hormone secretion and response to growth hormone treatment in children with short stature and intrauterine growth retardation. Acta Paediatr Scand [Suppl] 349: 47, 1989.Physiological growth hormone (GH) secretion was examined in 31 children (8 girls, 23 boys) with short stature secondary to intrauterine growth retardation (IUGR). Seventeen (4 girls, 13 boys) had dysmorphic features of Russell‐Silver syndrome. Four of the 31 children had GH insufficiency with peak GH levels of < 20 mU/I during the night. Nine of the patients (8 of whom had Russell‐Silver syndrome) had a single nocturnal GH pulse. Twenty‐three children (6 girls, 17 boys) were randomized into two groups treated with either 15 or 30 U/m2/week of GH by daily subcutaneous injections. Age, sex distribution, pretreatment height velocity SD score (SDS), and distribution of dysmorphic and non‐dysmorphic children were similar in both groups. The group treated with 15 U/m2/week for a mean of 0.82 years showed an increase in mean height velocity SDS from ‐ 0.61 to +1.09, and the group treated with 30 U/m2/week for a mean of 0.92 years showed an increase in mean height velocity SDS from ‐0.69 to +3.48. The results suggest that physiological GH insufficiency is probably common in children with Russell‐Silver syndrome and that both dysmorphic and non‐dysmorphic children with short stature secondary to IUGR will respond to GH treatment. Initial evidence suggests that the increase in short‐term growth velocity does not result in an improved final height prognosis.
Diagnostic Value of Growth Hormone‐Releasing Hormone Tests in Short Children
Authors: BUTENANDT O. 
Published: January 2008

ABSTRACT.Butenandt O. (Department of Paediatric Endocrinology, Children's Hospital, University of Munich, Munich, West Germany). Diagnostic value of growth hormone‐releasing hormone tests in short children. Acta Paediatr Scand [Suppl] 349 93, 1989.The growth hormone‐releasing hormone (GHRH) test was applied to more than 230 children. Twenty‐five out of 61 patients with proven growth hormone (GH) deficiency responded to GHRH with a GH increase of greater than 10 ng/ml. In most of the patients with idiopathic GH deficiency, a priming procedure using daily injections of GHRH improved the secretory response to GHRH. Nearly all children with familial shortness of stature showed a prompt increase in GH levels, with a mean peak level of 34.9 ng/ml (range 0.5–144 ng/ml). A second test was performed in five children with familial short stature because of failure to respond to the first test. Children with constitutional delay of growth and development did not differ in their GH response from patients with familial shortness of stature. Ten girls with Ullrich‐Turner's syndrome responded with a mean increase of 22 ng/ml GH (range 10.1–34.0 nglml). Therapy with glucocorticoids, as well as endogenous hypersecretion of cortisol, suppressed the responsiveness of the pituitary gland to GHRH. Suppression was also observed following a single dose of dexamethasone during the steroid‐suppression test in eight obese children. Low responsiveness of the pituitary gland was also seen in patients with thalassaemia and transfusion‐induced haemosiderosis. It is concluded that it is not possible to detect GH deficiency with a single GHRH test. A full endo‐crinological evaluation is necessary to prove the diagnosis.
Early child health in Lahore, Pakistan: VII. Diarrhoea
Authors: Mahmud A , Jalil F , Karlberg J , Lindblad BS 
Published: January 2008

Mahmud A, Jalil F, Karlberg J, Lindblad BS. Early child health in Lahore, Pakistan: VII. Diarrhoea. Acta Paediatr 1993;390(suppl):79–85. Stockholm. ISSN 0803–5326This study was carried out to obtain reliable prospective data on the incidence, home management and duration of infantile diarrhoeal disease in a developing and rapidly urbanizing community. Fourteen hundred and seventy six infants from 4 different communities of Lahore, representing different stages of urbanization, were followed prospectively from birth to 2 years of age. Each child had an average of 3.6 episodes of diarrhoea during one year; 4.3 episodes per child per year in the village, 4.4 in the periurban slum, 3.4 in the urban slum and 1.4 in the upper middle (Um) class control group. The maximum incidence of diarrhoeal episodes occurred in children between 9–10 months of age. No sex difference was found. The seasonal variation showed a peak incidence during April‐June. Bloody diarrhoea, in 3–5% of the episodes, was predominantly seen in winter months and in older infants. The maximum use of ORS was seen in the Um class (53%). Antibiotics were used in 75% of all diarrhoeal episodes maximally in the Um class, and morphine derivatives in 1% of all cases. The overall incidence of persistent diarrhoea was 14% of all acute cases, being highest in the village (18%), followed by the periurban slum (14%), Um class (10%) and urban slum (8%) with peak incidence occurring in June and July. Our results confirm the magnitude of the problem of diarrhoea. The proper selection of cohorts, the closely controlled prospective and simultaneous follow‐up study of these large samples representing different urbanization stages and socio‐economic conditions and the new detailed data on the duration of diarrhoeal episodes makes these results of wider international interest in addition to its importance for health planning in Pakistan.
Significance of measurement of pre‐S2 antigen for the prevention of vertical transmission of hepatitis B virus in infants born to HBsAg carrier mothers
Authors: Terazawa Sousuke , Kondo Naomi , Orii Tadao 
Published: January 2008

Terazawa S, Kondo N, Orii T. Significance of measurement of pre‐S2 antigen for the prevention of vertical transmission of hepatitis B virus in infants born to HBsAg carrier mothers. Acta Pædiatr 1994;83:30–4. Stockholm. ISSN 0803–5253The significance of pre‐S2 antigen (pre‐S2 Ag) as a marker of hepatitis B virus (HBV) infection, especially in infants born to HBsAg carrier mothers who are HBeAg‐negative or HBeAg‐positive, was evaluated. Pre‐S2 Ag was measured by enzyme immunoassay. HBsAg carrier mothers who were HBeAg‐negative and HBeAb‐positive were divided into two groups: group A, mothers whose infants were not infected with HBV (n =10) and group B, mothers whose infants were infected with HBV (n= 13). Absorption rates of pre‐S2 Ag in group A and B were 0.09 k 0.04 and 1.36 ± 0.95, respectively. The values for pre‐S2 Ag in group B were significantly higher than those in group A. Values for pre‐S2 Ag among HBsAg carrier mothers who were HBeAg‐positive and HBeAb‐negative were also measured by reversc passive hemagglutination. In the same way, HBsAg carrier mothers who were HBeAg‐positive and HBeAb‐negativc were divided into two groups: group C, mothers whose infants did not become HBsAg carriers (n =15) and group D, mothers whose infants became HBsAg carriers (n = 11). The titers of pre‐S2 Ag (reverse passive hemagglutination) in group C and D were 25.75 ± 1.68and 210.45±1.69, respectively. The values for pre‐S2 Ag in group D were significantly higher than those in group C. The values for pre‐S2 Ag as markers of infectivity became higher with increasing amounts of HBV‐DNA. Therefore, our results show that measurement of pre‐S2 Ag in HBsAg carrier mothers who are HBeAg or HBeAb‐positive is useful in the detection of high‐risk groups of vertical transmission of HBV.
Infective endocarditis in newborn infants with structurally normal hearts
Authors: Mecrow IK , Ladusans EJ 
Published: January 2008

Mecrow IK, Ladusans EJ. Infective endocarditis in newborn infants with structurally normal hearts. Acta Pædiatr 1994;83:35–9. Stockholm. ISSN 0803–5253.Twelve infants with structurally normal hearts were demonstrated to have intracardiac vegetations on echocardiography and diagnosed as having infective endocarditis. All were found in the right side of the heart, most frequently at the junction of the superior vena cava and the right atrium and in no case involved the tricuspid or pulmonary valves. Most were diagnosed in the course of investigation of repeatedly positive blood cultures, despite appropriate antibiotic therapy. Coagulase‐negative staphylococci were isolated from blood culture in nine infants, and Streptococcus sanguis and Candida albicans from one each. All infants had had intracardiac central lines inserted to facilitate venous access, either by a percutaneous technique or as a formal surgical procedure. Eight (67%) were successfully treated and made a full recovery. Cardiac murmurs were absent in all of the cases. Echocardiography should be included in the investigation of all neonates with persistently positive blood culture, particularly when intracardiac lines have been sited. Right‐sided, non‐valvar lesions and infection with coagulase‐negative staphylococci may carry a better prognosis than previously reported.
Interpretation of random urinary catecholamines and their metabolites in neuroblastoma
Authors: O'Meara A , Tormey W , FitzGerald RJ , Fitzgibbon M , Kenny D 
Published: January 2008

O'Meara A, Tormey W, Fitz Gerald RJ, Fitzgibbon M, Kenny D. Interpretation of random urinary catecholamines and their metabolites in neuroblastoma. Acta Paediatr 1994;83:88–92. Stockholm. ISSN 0803–5253This study reports experience in the estimation of urinary catecholamines (uCATs) and their metabolites in the diagnosis and follow‐up of neuroblastoma. Random urine samples were assayed for dopamine, noradrenaline and adrenaline, together with their metabolites 4‐hydroxy 3‐methoxyman‐delic acid (HMMA) and homovanillic acid (HVA), using HPLC with electrochemical detection. Twenty of 21 patients had elevation of one or more uCATs metabolites at diagnosis. Patients were monitored serially from diagnosis and, in those patients who had delayed resection of primary tumour (n=13), particular attention was paid to levels at the pre‐surgical evaluation as an indicator of persistence of viable disease at the time of surgery; dopamine proved to be the most accurate indicator of persistent disease at this time. Five of these patients developed recurrent disease, 4 of whom had elevation of two or more uCATs metabolites at the time of relapse. Several conclusions can be drawn from this study: (a) results for HMMA, HVA and dopamine in random urine samples will detect all but the most biochemically immature or inert tumours; (b) dopamine may be the most reliable indicator of persistent disease and (c) noradrenaline and adrenaline measurements were of little benefit. As results are Expressed in relation to urinary creatinine, excretion of which may be affected by dietary protein and is therefore not constant, borderline results should be repeated.
Treadmill exercise in Neapolitan children and adolescents
Authors: Maffulli Nicola , Greco Raffaele , Greco Luigi , D'Alterio Doriana 
Published: January 2008

Maffulli N, Greco R, Greco L, D'Alterio D. Treadmill exercise in Neopolitan children and adolescents. Acta Pædiatr 1994;83:106–112. Stockholm ISSN 0803–5253Two hundred and eighty healthy children from Naples, Italy (140 boys and 140 girls) aged 4–17 years were studied using Bruce walking treadmill protocol to voluntary exhaustion. Endurance time and double product increased with age. Systolic blood pressure increased linearly during the test. Multivariate analysis showed that body weight and age were the best predictors of endurance time. Endurance time averaged 15.2 ± 2.8 min in boys and 13.7 ± 2.3 min in girls (p= 0.0001). Mean±SD double product at peak exercise was 264.3 ± 63 (boys) and 242 ± 44 (girls) (p = 0.01). Sinus arrhythmia was present in 78% of the children and disappeared at a mean heart rate of 112 ± 16 beats/min during exercise. The voltage of the R wave on V4 lead decreased in all but four children during the test (delta R= ‐0.25±0.24 mV). The P and T waves increased in almost all children. No ST depression or upward sloping was detected. The voltage of the PR isoelectric line remained constant. The J point was displaced downwards in 78% of children, unchanged in 11% and displaced upwards in the remaining 11% of the children. The present study gives reference parameters for a walking treadmill test in Southern European children.
Aminohydroxypropylidene‐biphosphonate in the treatment of bone lesions in a case of Gaucher's disease type 3
Authors: Bembi B , Agosti E , Boehm P , Nassimbeni G , Zanatta M , Vidoni L 
Published: January 2008

Bembi B, Agosti E, Boehm P, Nassimbeni G, Zanatta M, Vidoni L. Aminohydroxypropylidene‐biphosphonate in the treatment of bone lesions in a case of Gaucher's disease type 3. Acta Pædiatr 1994;83:122–4. Stockholm. ISSN 0803–5253Gaucher disease is the most prevalent lysosomal storage disorder. It is characterized by an autosomal recessive inheritance of a deficiency of lysosomal acid glucocerebrosidase. Three clinical phenotypes are recognized: type 1 (non‐neuronopathic), type 2 (acute neuronopathic), type 3 (subacute neuronopathic). Bone lesions are associated with type 1 and type 3 Gaucher disease. Skeletal involvement is secondary to the progressive accumulation of histiocytes and macrophages laden with glucosylceramide in bone marrow. Our patient was a female type 3 Gaucher patient who was referred to us at the age of 3 years with a neurological symptomatology and severe bone lesions (bilateral fracture of the femur heads, lytic process of the bone matrix of the femurs and distal flask deformity, kyphoskoliosis and chest deformity). The baby was constrained to a wheel‐chair. The use of (3‐amino‐1‐hydroxypropylidene)‐1,1‐biphosphonate (APD) was described in a case of Gaucher disease with very severe bone lesions. We used periodic iv infusions of APD (10 mg every 3 weeks) in our patient for a period of 20 months; after that, enzyme replacement therapy (alglucerase) was commenced. APD treatment showed normalization of bone density, formation of bone callus at the femural heads, positive calcium balance. The urinary Ca/Cr ratio and TRP were consistently normal during therapy. After 9 months of algucerase therapy the patient was able to walk again. The data indicate that APD therapy can find an indication in Gaucher patients with severe bone involvement.
Growth and skeletal maturation in children with phenylketonuria
Authors: Schaefer F , Burgard P , Batzler U , Rupp A , Schmidt H , Gilli G , Bickel H , Bremer HJ 
Published: January 2008

Schaefer F, Burgard P, Batzler U, Rupp A, Schmidt H, Gilli G, Bickel H, Bremer HJ. Growth and skeletal maturation in phenylketonuria. Acta Paediatr 1994;83:534–41. Stockholm. ISSN 0803–5253Growth and skeletal maturation was evaluated in 82 children participating in the German Colkdborative Study of Children Treated for Phenylketonuria (PKU). Height, weight, head circumference and bone age were recorded at regular intervals for the first 6 years of life. The mean SD score (SDS) for height was not significantly different from zero at study entry, but decreased mainly during the second year of life to a nadir of ‐0.78 in boys and ‐0.54 in girls at 2.5 years. During the subsequent years, a significant trend towards a regain of height SDS was noted in both sexes. Weight‐for‐height SDS was close to zero in both sexes, with a significant continuous increasing trend throughout the observation period. Head circumference SDS decreased in boys during the first year of life from ‐0.28 to ‐0.68, whereas girls showed only a minor change. During the further follow‐up period, head circumference SDS remained at approximately ‐0.3 in boys and 0.0 in girls. While the mean verbal and performance IQ of the total study population at 5 and 6 years of age did not differ from a group of 212 healthy non‐PKU children, patients with a head circumference SDS less than the population median at 2 years of age exhibited poorer cognitative abilities at school age than those patients with a relative head size greater than the population median. The children with a head circumference less than the median at 2 years had smaller head sizes already at birth; in addition, the change in relative head size during the first 2 years was correlated significantly with cognitive abilities at school age in boys. Mean bone age was identical to chronological age at each time point of observation. The rate of maturation was one year of bone age per year of chronological age. No correlation between phenylalanine intake or phenylalanine concentrations and the rates of body or head growth or skeletal maturation could be established. We conclude that despite adequate weight gain, moderate growth retardation occurred during the first 2 years of life in this group of children treated for PKU. Growth was more compromised in boys than in girls and tended to be compensated during later follow‐up. Early infantile head circumference and growth appear to be predictors of cognitive development.
Familial chronic myelocytic leukaemia‐like syndrome probably of congenital origin
Authors: Lardi Amer A , Taha Omer MA , Al‐Jefri Abdulla , Ahmed Mirghani AM 
Published: January 2008

Lardi AA, Taha OMA, Al‐Jefri A, Ahmed MAM. Familial chronic myelocytic leukaemia‐like syndrome probably of congenital origin. Acta Pædiatr 1994;83:558–60. Stockholm. ISSN 0803–5253Three Saudi siblings prcsented with clinical features of chronic myelocytic leukaemia in early infancy. Their parents are first cousins. The mother was 22 years old during her first pregnancy. She had no history of abortion. The possibility of this familial disorder being congenital is discussed. □