bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ion‐Scale Characteristics of the Martian Magnetic Pile‐Up Boundary Layer
Authors: Li Shibang , Wang Siqi , Lu Haoyu , Cao Jinbin , Wu Xiaoshu , Ge Yasong , Wild James A. , Dong Chuanfei , Chen Nihan , Song Yihui , Wang Jianxuan , Cao Yuchen , Zhao Jianing 
Published: February 2025

AbstractThe Martian magnetic pile‐up boundary (MPB) delineates the interface between the magnetosheath and the induced magnetosphere, but its global ion‐scale characteristics remaining unclear. Utilizing a three‐dimensional Hall magnetohydrodynamic (MHD) model, this study aims to reveal the features of the MPB layer, including magnetic field, current density, electric fields, and energy transfer between the fields and solar wind as well as planetary ions. Simulation results indicate that magnetic fields tend to pile‐up, drape, bend, and slip at the MPB, leading to the emergence of associated currents () from the nightside electric pole and its flow toward the dayside electric pole along the MPB. Furthermore, energy transfer analysis demonstrates that the solar wind transfers its energy to planetary ions through the motional electric field while simultaneously acquiring some energy from the Hall and ambipolar electric fields at the MPB, resulting in an asymmetrical flow of solar wind and planetary ions.
Impact of Diagenesis on Biogenic Silica‐ Structural, Chemical, and Isotope Proxies
Authors: Stamm Franziska M. , Pickering Rebecca A. , Frings Patrick J. , Frick Daniel A. , Richoz Sylvain , Conley Daniel J. 
Published: February 2025

AbstractThe silicon isotope composition (δ30Si) of biogenic silica is often used as an archive of past environmental conditions. For example, sponge spicule δ30Si is known to be related to seawater‐dissolved Si concentrations. Such a proxy application requires that the δ30Si is not diagenetically altered—or at least that any alteration can be identified and accounted for. Yet the preservation of pristine isotope signals during (early) diagenesis is challenged by observations of structural changes to the amorphous silica (opal‐A) of biogenic silica toward a more stable amorphous silica phase (opal‐CT). This transformation is known to be associated with a resetting of oxygen isotope (δ18O) values but with unclear implications for the preservation of other geochemical signatures. This was investigated using modern and Cretaceous siliceous sponge spicules. Modern spicules collected from different ocean basins were uniformly transparent opal‐A, whereas Cretaceous spicules exhibited two preservation states: visually similar to modern or clearly altered toward a milky, translucent composition. A comparison of δ30Si and δ18O values of spicules from both categories within single samples reveals the milky, translucent individuals are offset from the transparent individuals and thus presumably unsuitable for palaeoenvironmental applications. A suite of geochemical and structural analyses (XRD, Raman spectroscopy, and FT‐IR spectroscopy) demonstrate that even visually clear Cretaceous spicules are subtly different from their modern counterparts, implying caution is required when interpreting δ30Si values or other geochemical proxies in ancient biogenic silica.
Estimating Soil‐Water Characteristic Curve From the Particle Size Distribution With a Novel Granular Packing Model
Authors: Wang Chong , Wu Yumo , Xie Liang , Yang Zhijie , Tian Jiaqi , Yu Fan , Ren Junping , Li Shuangyang 
Published: February 2025

AbstractAn indirect method is nowadays considered as an efficient way to obtain soil‐water characteristic curve (SWCC) in engineering application. However, existing indirect models often oversimplify the soil pore and accumulation structure, which are not consistent with the natural soil. For this purpose, a novel granular packing state is obtained based on the relative compaction determined by porosity. A conceptual SWCC model (WANG24) is then established with particle size distribution (PSD) and the equivalent novel granular packing. 62 soils from 7 soil texture classes in the UNSODA database were used to validate WANG24. When comparing with the Mohammadi and Vanclooster (MV11), Arya and Heitman (AH15), and Arya and Paris (AP81) models, WANG24 shows its highest accuracy with lowest average root mean square error (RMSE) of 0.0243 (g·g−1). The capillary and adsorption on SWCC are also analyzed. The absolute errors between the soil water content predicted by equivalent novel granular packing and measured data are smaller than those of other packing states, mostly in the range of 0–0.015 (g·g−1). The soil packing states tend to be closer as the particle size decreases. In addition, the effect of initial void ratio to soil water content and matric head is explained. The model can reasonably describe the complexity of soil accumulation structure and improve prediction accuracy. It can provide a basis and reference for the subsequent hydraulic characterization of unsaturated soils.
Neoadjuvant apatinib addition to sintilimab and carboplatin-taxane based chemotherapy in patients with early triple-negative breast cancer: the phase 2 NeoSAC trial
Authors: Shen Guoshuang , Liu Zhilin , Wang Miaozhou , Zhao Yi , Liu Xinlan , Hou Yujin , Ma Wenbiao , Han Jingqi , Zhou Xiaofeng , Ren Dengfeng , Zhao Fuxing , Li Zitao , Huang Shifen , Chen Yongzhi , He Yingjian , Liu Yan , Zhu Zijun , Li Yongxin , Li Jinming , Da Mengting , Mo Hongnan , Du Feng , Cui Liang , Bai Jing , Liu Zhen , Ma Fei , Zhao Jiuda 
Published: February 2025

Abstract
We aimed to evaluate the efficacy and safety of adding apatinib, to sintilimab and chemotherapy in the neoadjuvant treatment of early triple-negative breast cancer (TNBC). In the phase 2 NeoSAC trial, patients with early TNBC received six cycles of apatinib, sintilimab, nab-paclitaxel, and carboplatin followed by surgery. The primary endpoint was pathological complete response (pCR) rate. Specimens collected pre-neoadjuvant therapy and post-surgery were retained for comprehensive analysis of predictive biomarkers and the impact on the tumor microenvironment. Among 34 enrolled patients, 24 achieved pCR (70.6%; 95% confidence interval (CI), 53.0-85.3), and 79.4% (95% CI, 65.1-93.7) had residual cancer burden 0-I. Imaging evaluation showed 21 complete responses (61.8%) and 13 partial responses (38.2%). The most common grade 3-4 adverse events were leukopenia (47%), neutropenia (36%), and thrombocytopenia (24%). The 36-month disease-free survival rate stood at 94.1% with a median follow-up of 39.1 months. Notably, baseline high ImmuneScore, immune cell infiltration, and enrichment of interferon-related pathways correlated with pCR. Comparison of pre-neoadjuvant and post-surgery data revealed that the pCR group treated with this novel regimen exhibited an upregulation of distinct immune cell subsets, thereby activating the tumor microenvironment. Moreover, higher oxeiptosis scores were associated with an increased likelihood of achieving pCR. Following neoadjuvant therapy, the pCR group showed a decrease in oxeiptosis score, whereas the non-pCR group exhibited an increase. Our study suggests that apatinib, sintilimab combined with carboplatin and nab-paclitaxel chemotherapy showed a promising clinical activity and manageable safety profile in early TNBC and merits further study. ClinicalTrials.gov registration: NCT04722718.
Blimp-1 orchestrates macrophage polarization and metabolic homeostasis via purine biosynthesis in sepsis
Authors: Peng Wenjuan , Qin Qiushi , Li Rui , Liu Yujia , Li Lan , Zhang Yue , Zhu Liuluan 
Published: February 2025

Abstract
Sepsis is a life-threatening condition characterized by a dysregulated immune response to infection, leading to systemic inflammation and organ dysfunction. Macrophage polarization plays a critical role in pathogenesis of sepsis, and the influence of B lymphocyte-induced maturation protein-1 (Blimp-1) on this polarization is an underexplored yet pivotal aspect. This study aimed to elucidate the role of Blimp-1 in macrophage polarization and metabolism during sepsis. Using a murine cecal ligation and puncture model, we observed elevated Blimp-1 expression in M2 macrophages. Knockdown of Blimp-1 by macrophage-targeted adeno-associated virus in this model resulted in decreased survival rates, exacerbated tissue damage, and impaired M2 polarization, underscoring its protective role in sepsis. In vitro studies with bone marrow-derived macrophage (BMDM), RAW264.7, and THP-1 cells further demonstrated Blimp-1 promotes M2 polarization and modulates key metabolic pathways. Metabolomics and dual-luciferase assays revealed Blimp-1 significantly influences purine biosynthesis and the downstream Ornithine cycle, which are essential for M2 macrophage polarization. In vitro studies with BMDM further suggested that the purine biosynthesis and Ornithine cycle metabolic regulation is involved in Blimp-1’s effects on M2 macrophage polarization, and mediates Blimp-1’s impact on septic mice. Our findings unveil a novel mechanism by which Blimp-1 modulates macrophage polarization through metabolic regulation, presenting potential therapeutic targets for sepsis. This study highlights the significance of Blimp-1 in orchestrating macrophage responses and metabolic adaptations in sepsis, offering valuable insights into its role as a critical regulator of immune and metabolic homeostasis.
Parameterized resetting model captures dose-dependent entrainment of the mouse circadian clock
Authors: Masuda Kosaku , Yoshimoto Ryusuke , Li Ruoshi , Sakurai Takeshi , Hirano Arisa 
Published: February 2025

Abstract
The phase response curve (PRC) represents the time-dependent changes in circadian rhythm phase following internal or external stimuli. However, this time dependence complicates PRC measurement and quantification owing to its variable shape with changing stimulus intensity. Our previous work demonstrated that resetting a desynchronized circadian clock (singularity response, SR) simplifies the analysis by requiring only amplitude and phase parameters. In this study, we construct a comprehensive model for phase resetting in the mouse circadian clock by converting PRCs into SR parameters. We analyze single-cell PRCs and show that the SR amplitude parameters for different stimulus concentrations follow the Hill equation. Additionally, the model predicts the combined effects of multiple stimuli and pre-treatment (background) on phase response by simple addition or subtraction of individual SR parameters. Experimental validation using SR measurements in mouse cells and tissues confirms the model’s accuracy. This study demonstrates that SRs facilitate PRC quantification and reveal simple rules governing phase resetting properties under various conditions using SR parameters.
Sustainable synthesis and advanced optimization of Prosopis juliflora biomass catalyst for efficient biodiesel production and environmental impact assessment
Authors: Rao Thota S S Bhaskara , Gnanaprakasam Manikandaraja , Manimaran Rajayokkiam , Balasubramanian Dhinesh , Kale Utku , Kilikevičius Artūras 
Published: February 2025

Abstract
The present research focuses on developing an innovative biochar-based heterogeneous catalyst from Prosopis Juliflora biomass waste using response surface methodology and genetic algorithm (GA) to optimize pyrolysis parameters, achieving a 46.31% PJBC yield from 60 mg of biomass at 790 °C for 60 min. The pyrolyzed PJBC is characterized using SEM, FTIR, XRD, EDX, BET, XPS analyses, and physico-chemical measurements to confirm its catalytic activity. Now, the newly synthesized PJBC serves as an efficient catalyst for waste Trichosanthes cucumerina seed biodiesel (WTSB) production from waste Trichosanthes cucumerina seed bio-oil through trans-esterification, achieving a maximum yield of 97.42%. Also, the WTSB exhibits excellent physico-chemical properties that meet most of the ASTM D6751 standards for biodiesel and closely align with the characteristics of conventional diesel fuel. Therefore, this research utilized neat WTSB and WTSB/diesel blends (WTSB25, WTSB50, and WTSB75) in a direct injection (DI) diesel engine at variable load settings. Among all WTSB blends, the WTSB25 blend showed closer variations of 1.65% lower BTE and 9.29% higher BSEC when compared to conventional diesel fuel readings. Its peak in-cylinder pressure and heat release rate were similar to those of diesel fuel at 100% engine load. Emission analysis indicated that the WTSB25 reduced specific HC, CO, and smoke opacity emissions by 8.39%, 13.97%, and 4.18%, respectively. However, specific NO emissions increased slightly by 3.05% compared to diesel fuel. Thus, WTSB25 is validated as a viable diesel alternative requiring no significant engine modifications. The environmental impact, lifecycle and economic feasibility are also discussed.
Trichromacy is insufficient for mate detection in a mimetic butterfly
Authors: Dang Andrew , Bernard Gary D. , Yuan Furong , Macias-Muñoz Aide , Hill Ryan I. , Lawrence J. P. , Rangel Olguin Aline Giselle , Luis-Martínez Armando , Mullen Sean P. , Llorente-Bousquets Jorge , Briscoe Adriana D. 
Published: February 2025

Abstract
Color vision is thought to play a key role in the evolution of animal coloration, while achromatic vision is rarely considered as a mechanism for species recognition. Here we test the hypothesis that brightness vision rather than color vision helps Adelpha fessonia butterflies identify potential mates while their co-mimetic wing coloration is indiscriminable to avian predators. We examine the trichromatic visual system of A. fessonia and characterize its photoreceptors using RNA-seq, eyeshine, epi-microspectrophotometry, and optophysiology. We model the discriminability of its wing color patches in relation to those of its co-mimic, A. basiloides, through A. fessonia and avian eyes. Visual modeling suggests that neither A. fessonia nor avian predators can readily distinguish the co-mimics’ coloration using chromatic or achromatic vision under natural conditions. These results suggest that mimetic colors are well-matched to visual systems to maintain mimicry, and that mate avoidance between these two look-alike species relies on other cues.
Incorrect Statements and Citing Errors Regarding the Effect of Ankyloglossia on Speech in Cordray et al., 2023
Authors: Kummer Ann W. 
Published: February 2025

Purpose:
There is a great deal of misinformation among professionals about the effect (or lack thereof) of ankyloglossia on speech. Consequently, many children undergo unnecessary frenotomy procedures that do not improve their speech and may cause unnecessary complications. This letter points out several erroneous statements in Cordray et al. (2023) about the effect of ankyloglossia on speech. In addition, it identifies articles that were incorrectly cited to support these statements. This letter also reveals significant errors of omission, including the results of the systematic review from the Agency for Healthcare Research and Quality, which found that there is insufficient evidence to conclude that ankyloglossia affects speech. Another omission was the consensus statement from the American Academy of Otolaryngology–Head and Neck Surgery Consensus Report, which states that ankyloglossia does not typically affect speech. Finally, this letter details the reasons why ankyloglossia is highly unlikely to affect speech.

Conclusion:
Contrary to statements made in Cordray et al. (2023), there is no evidence that ankyloglossia affects speech production, and therefore, it is highly unlikely to be the cause of a speech sound disorder. This is because even with severe restriction of tongue tip movement, a compensation (or alternative method of production) can be used to produce lingual phonemes with the same acoustic output.
A state‐variable‐preserving method for the efficient modelling of inverter‐based resources in parallel EMT simulation
Authors: Wang Qiguo , Xu Jin , Wang Keyou , Li Guojie , Feng Zhenyuan 
Published: February 2025

AbstractThe aggregation models of renewable energy power stations are difficult to apply to the stability research of the fault inside the station or the oscillation analysis between the station and the grid‐side system, and the high dimensional characteristics of their detailed model will pose an enormous challenge to the simulation efficiency. To alleviate the contradiction between accuracy and efficiency, this paper proposes a state‐variable‐preserving method to efficiently model inverter‐based resources and a node tearing method to realize parallel simulation of the renewable energy power station consisting of inverter‐based resources. The state‐variable‐preserving model uses discrete state space expression to eliminate the internal nodes on the basis of preserving the original variables of the generation unit and reduces the solving scale of the generation station. The node tearing method reduces the solving complexity of the associated variables, which is more consistent with the topology characteristic that different power generation clusters are interconnected by the same bus. In the case study, the results of numerical accuracy analysis and numerical stability analysis of a photovoltaic power plant verify the reliability of the proposed method, and its simulation efficiency is verified by changing the scale of the photovoltaic power plant.
Dynamic smart contracts framework on Ethereum private blockchain for real estate management
Authors: Jamshed Huma , Waheed Urooj , Iqbal Shahid , Faheem Muhammad , Ashraf Muhammad Waqar , Mansoor Yusra 
Published: February 2025

AbstractBlockchain technology enables the recording of information in an immutable manner, making it extremely difficult or nearly impossible to alter, hack, or manipulate. Its adoption is expected to enhance long‐term economic sustainability across various industries, including real estate. Traditional real estate transactions typically involve third‐party intermediaries to record and validate informal transactions. However, blockchain technology has the potential to revolutionize the real estate sector by transforming how properties are bought and sold. Features such as efficiency, transparency, process automation through smart contracts, robust consensus mechanisms, and enhanced security measures can reshape the real estate landscape by increasing efficiency and reducing costs. This paper explores the challenges currently faced by the real estate industry and reviews the literature on the disruptive impact of blockchain technology in this sector. A conceptual framework for a private blockchain is proposed based on the Ethereum platform, utilizing proof of authority as the consensus mechanism, specifically designed for property transactions. The proposed model integrates self‐sovereign identity for secure and decentralized identity management, incorporates digital wallets for transaction management, and leverages smart contracts to automate processes. This approach enhances transparency in digital transactions, thereby fostering greater trust between users and service provider.
The effectiveness of FAT‐Net in chest X‐ray segmentation
Authors: Khorasani Maedeh Sadat , Babapour Mofrad Farshid 
Published: February 2025

AbstractObjective: The segmentation of lung images is intricate due to the varied forms and distortions caused by the disease. One of the standard tools for checking and diagnosing lung diseases is CXR images. In this regard, the effectiveness of the FAT‐Net network for automatic segmentation of lung CXR images was investigated. To our knowledge, research has yet to employ the proposed network to segment lung CXR images.Materials and methods: The suggested network's performance was compared to two pre‐existing networks, Attention U‐Net and SegNet. Evaluations were performed on two public datasets named Montgomery and Shenzhen. After preprocessing the data, all three models were trained and evaluated.Results: The accuracy and Dice obtained for the proposed network are 98.12 and 96.10, respectively, and the average IOU index, which dominates the Attention U‐Net and SegNet networks, shows the stability and the suggested network outperforms previous networks reported in the literature for lung image segmentation and is more robust than the other two networks.Conclusion: According to the evaluations performed on the Montgomery and Shenzhen datasets, the proposed network has provided more accurate and reliable segmentation for lung CXR images by mastering the two networks above.
The Effect of Electronic Health Record and Immunization Information System Interoperability on Medical Practice Vaccination Workflow
Authors: Dombkowski Kevin J. , Patel Pooja N. , Peng Hannah K. , Cowan Anne E. 
Published: February 2025

Abstract
Background Interoperability between electronic health records (EHR) and immunization information systems (IIS) may positively influence data quality, affecting timeliness, completeness, and accuracy of these data. However, the extent to which EHR/IIS interoperability may influence the day-to-day vaccination workflow and related recordkeeping tasks performed at medical practices is unclear.
Objective This study aimed to assess how EHR/IIS interoperability may influence the vaccination workflow at medical practices and to identify related impacts on clinical and administrative activities.
Methods We identified practices (family medicine, pediatrics, internal medicine, local health departments) from the Michigan Care Improvement Registry (MCIR), the statewide IIS in Michigan, representing each of the three HL7 interoperability levels (non-HL7, unidirectional, bidirectional). We conducted semi-structured interviews to assess how practices interact with the MCIR throughout the vaccination workflow. Transcripts were reviewed and coded to characterize practices' use of EHRs, MCIR, and other related technologies across the vaccination workflow.
Results Practices completed Phase 1 (n = 45) and Phase 2 (n = 42) interviews, representing a range of medical specialties, geographic locations, and sizes. HL7 connectivity expanded among the participating practices; by the conclusion of the study, all practices had initiated at least unidirectional HL7 capability. Providers and staff relied heavily upon both their EHRs and MCIR throughout a wide range of vaccination-related activities. Most practices relied on MCIR as their primary source of vaccination history information, and nearly all practices also reported use of paper forms, documentation, and other summaries throughout the vaccination workflow.
Conclusion Practices employed both their EHRs and IIS throughout the entire vaccination workflow, although the use of each relied heavily on paper-based processes. While benefits of adopting EHR/IIS interoperability were reported by practices, this may require staff to learn and implement new workflow processes that can be time consuming and may introduce new challenges.