bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peracetic acid as a superior oxidant for preparation of [123I]IBZM: A potential dopamine D‐2 receptor imaging agent
Authors: Kung Mei‐Ping , Kung Hank F. 
Published: October 2006

AbstractVarious oxidizing agents: chloramine‐T, hydrogen peroxide, sodium persulfate, m‐chloroperoxybenzoic acid and peracetic acid were examined as the oxidant for preparing radioiodinated IBZM ((S)‐(–)‐3‐ iodo‐2‐hydroxy‐6‐methoxy‐N‐[(1‐ethyl‐2‐pyrrolidinyl)methyl]benzamide), which is a useful dopamine D‐2 receptor imaging agent. Of all the oxidizing agents tested, peracetic acid appears to be the best agent for no‐carrier added radioiodination. The advantages of using peracetic acid as the oxidant for the preparation of [125I] or [123I] IBZM include: high radiochemical yield, high radiochemical purity, and short reaction time at room temperature.
A general synthetic method suitable for the introduction of deuterium or tritium in buspirone type anxiolytic agents
Authors: Welch Willard M. , Viverios D. M. 
Published: October 2006

AbstractIn recent years, a number of putative non‐benzodiazepine anxiolytic agents incorporating the 4‐ aminobutylimide or sulfonamide‐imide linkage have been reported and at least two of these, buspirone and gepirone, have been shown to have anxiolytic activity in man. In order to study the metabolism, body distribution and binding affinities of this class of compound, it was of interest to devise a precursor which could be specifically labelled with tritium to high specific activity. We have devised a synthetic route to the corresponding but‐2‐ynyl and but‐2‐enyl analogs of gepirone and have converted the latter to dideuterogepirone as an example of the methodology. Thus the method chosen has been found to be practical and is believed to be of sufficient generality to enable the synthesis of a variety of derivatives of this type containing either two or four atoms of label. Furthermore by appropriate choice of reagents, incorporation of 14C into these compounds may be achieved.
Synthesis and evaluation of biological activity of two novel tritium‐labeled derivatives of riodipine
Authors: Shevchenko V. P. , Myasoedov N. F. , Soldatov N. M. , Duburs G. J. , Kastron V. V. , Skrastinš I. P. 
Published: October 2006

Abstract2, 6‐Dimethyl‐3‐methoxycarbonyl‐5–([2, 3‐3H2] ‐n‐propoxy‐carbonyl)‐4‐(2′ ‐difluoromethoxyphenyl)‐1, 4‐dihydropyridine and 2, 6‐dimethyl‐3, 5‐di([2, 3‐3H2] ‐n‐propoxycarbonyl)‐4‐(2′‐difluoromethoxyphenyl)‐1, 4‐dihydropyridine were prepared by catalytic tritiation of the respective 3‐allyloxy‐carbonyl and 3,5‐di (allyloxycarbonyl) derivatives of riodipine. The two novel radioactively labeled 1,4‐dihydropy‐ridine derivatives obtained were shown to be suitable molecular tools for the identification of membrane‐bound and solubilized dihydropyridine receptors associated with calcium channels in rabbit skeletal muscle.
Synthesis of carbon‐14 and tritium labeled dopamine beta‐hydroxylase inhibitors of the imidazolinethione type
Authors: Senderoff S. G. , Shilcrat S. C. , Levinson S. H. , Heys J. R. 
Published: October 2006

Abstract1‐[(3,5‐Difluoro‐4‐hydroxyphenyl)methyl]‐1,3‐dihydro‐2H‐imidazole‐2‐thione, 1‐[(3,5‐difluoro‐4‐methoxyphenyl)methyl]‐1,3‐dihydro‐2H‐imidazole‐2‐thione, and 1‐[(3,5‐difluorophenyl)methyl]‐1,3‐dihydro‐2H‐imidazole‐2‐thione (SK&F 102048, SK&F 102055 and SK&F 102698, respectively) were synthesized in carbon‐14 and tritium labeled forms. Carbon‐14 from potassium [14 C]thiocyanate was incorporated into the imidazolethione ring of SK&F 102055 and SK&F 102698 at C‐2 by condensation with N‐(2,2‐dimethoxyethyl)‐3,5‐difluoro‐4‐methoxybenzenemethanamine or N‐(2,2‐dimeth‐oxyethyl)‐3,5‐difluorobenzenemethanamine. Treatment of SK&F [2‐14 C] 102055 with boron tribromide gave SK&F [2‐14 C] 102048. Tritiated SK&F 102048 was synthesized by sodium [3H]borohydride reduction of N‐(3,5‐difluoro‐4‐methoxyphenylmethylene)‐2,2‐dimethoxy‐ethanamine, followed by condensation with potassium thiocyanate and demethylation with boron tribromide.
Structure biodistribution relationship of radiolabeled ergolines: Search for brain imaging radiopharmaceuticals
Authors: Basmadjian G. P. , Sadek S. A. , Mikhail E. A. , Parikh A. , Weaver A. , Mills S. L. 
Published: October 2006

AbstractA series of ergoline derivatives, analogues of Pergolide 1 and Lysergol 6, were synthesized, radiolabeled with 125I or 75Se, and evaluated for their ability to cross the Blood Brain Barrier of rats, for potential use as radiopharmaceuticals for imaging the brain. Introduction of the radiolabel was either at the 17‐ position (attached to the 8β‐methylene) or at the 2‐ position of the indole portion of the ergoline moiety. Of the 8 radiolabeled compounds tested, two pergolide analogues, 8β‐(methyl‐75Seseleno)‐methyl‐6‐propyl ergoline 5 and 8β−[125I]‐iodomethyl‐6‐propyl ergoline 2f showed the highest uptake in the brain, adrenal and heart with good organ to blood ratios. This work has shown that analogues of pergolide, a dopamine agonist, if labeled with 123I may yield a clinically useful brain imaging radiopharmaceutical.
Synthesis of 7‐benzyl‐7‐aza‐3‐thiabicyclo[3.3.1]nonane hydroperchlorate‐6,8,10‐14C3
Authors: Zisman Stan A. , Darrell Berlin K. , Alavi Fereidon K. , Sangiah Subbiah , Clarke Cyril R. , Scherlag Benjamin J. 
Published: October 2006

AbstractA synthesis of 7‐benzyl‐7‐aza‐3‐thiabicyclo[3.3.1]nonane hydroperchlorate‐6,8,10‐14C3 (2) is described via a Mannich type of condensation. 4‐Thianone (3) was treated with 14C‐labelled benzylamine (14CH2) and paraformaldehyde [(H214C=O)n] in a solution of acetic acid with a small amount of concentrated HCl added for a period of six hours at reflux under nitrogen. Workup with aqueous sodium hydroxide followed by treatment with a high vacuum technique provided 7‐benzyl‐7‐aza‐3‐thiabicyclo[3.3.1]nonan‐9‐one‐6,8,10‐14C3 (4). Reduction of 4 under Wolff‐Kishner conditions with hydrazine/KOH in triethylene glycol at the boiling point of o‐xylene provided the corresponding crude amine after workup. Treatment with 60% perchloric acid (below 5°C) resulted in the formation of the title compound 2 which could be recrystallized (95% ethanol). The melting point and spectral data confirmed the structure which had a specific activity of 0.64 μCi/mg.
The synthesis of [3H] ‐ indole‐3‐carbinol, a natural anti‐carcinogen from cruciferous vegetables
Authors: Dashwood Roderick H. , Uyetake Lyle , Fong Arthur T. , Hendricks Jerry D. , Bailey George S. 
Published: October 2006

AbstractIndole‐3‐carbinol is a natural anti‐carcinogen found as a glucosinolate in cruciferous vegetables such as cabbage, cauliflower and broccoli. A complete understanding of the mechanisms of anti‐carcinogenesis by this dietary inhibitor requires improved insight into the disposition and metabolic fate of indole‐3‐carbinol in vivo. Such metabolic studies have been hampered by the lack of a commercial source of radiolabelled compound. This provided the main impetus for the work reported here, the synthesis of 5‐[3H]‐indole‐3‐carbinol from 5‐bromoindole.
Synthesis of [21‐14C]‐fusarin C by enzymic demethylation and remethylation with [14C]‐diazomethane
Authors: Lu S‐J. , Li M. H. , Jeffrey A. M. 
Published: October 2006

AbstractFusarin C, a potent mutagen isolated from Fusarium moniliforme culture extracts, has been prepared radiolabeled in two steps by enzymic hydrolysis of the 21‐methyl ester group, using phenobarbital induced microsomal preparations, followed by remethylation using [14C]‐diazomethane. Yields, based upon fusarin C, were essentially quantitative and approximately 10% of the [14C]‐methyl‐nitrosourea, converted to diazomethane, reacted to yield [14C]‐fusarin C.
Synthesis of [methine‐3H]ddt and its nitro‐analog, and isotope effects in their enzyme‐catalyzed dehydrochlorination
Authors: Kurihara N. , Ikemoto Y. , Okutani S. , Clark A. G. 
Published: October 2006

Abstract[methine‐3H]1,1‐Di‐(4‐chlorophenyl)‐2,2,2‐trichloroethane ([methine‐3H]DDT) and its di‐(4‐nitrophenyl) analog, both of high purity with a moderately high specific activity were prepared. Chlorobenzene was condensed with [1‐3H]1‐(4‐chlorophenyl)‐2,2,2‐trichloro‐ethanol, which had been synthesized by sodium boro[3H]hydride reduction of 4‐chlorophenyl trichloromethyl ketone. The purified [3H]DDT had a specific activity of 0.77 Ci/mmol (28.49 GBq/mmo 1). [methine‐3H]1, 1‐Diphenyl‐2,2,2‐trichloroethane was similarly synthesized and was nitrated to give [methine‐3H]1,1‐di‐(4‐nitrophenyl)‐2,2,2‐trichloroethane of 1.63 Ci/mmol (60.31 GBq/mmol). Dehydrochlorination with housefly enzyme (glutathione‐dependent DDT dehydrochlorinase) showed a remarkable isotope effect. For DDT, the observed tritium isotope effect on Vmax/Km was 11.51±0.52. For the nitro‐analog, the value was 11.3±1.2. We measured deuterium isotope effect on Vmax/Km for DDT in a competitive mode and obtained the value 4.19±0.34. Based on these values, the magnitude of intrinsic isotope effect values on DDT‐dehydrochlorination reaction was discussed.
Synthesis of [3H]‐1‐[1‐(3‐isothiocyanatophenyl) cyclohexyl]piperidine (METAPHIT), an acylating agent for phencyclidine receptors
Authors: De Costa Brian R. , Lessor Ralph A. , Thurkauf Andrew , Highet Robert J. , Jacobson Arthur E. , Rice Kenner C. 
Published: October 2006

AbstractThe preparation of [3H]‐labelled 1‐[1‐(3‐isothiocyanatophenyl) cyclohexyl]piperidine (METAPHIT), an electrophilic acylating agent for the phencyclidine (PCP) site is described. Synthesis of [3H]METAPHIT was accomplished in three steps starting from 1‐[1‐(3‐nitrophenyl)cyclohexyl]piperidine. Introduction of the tritium‐label in 20.6% radiochemical yield was achieved in the penultimate step.
Synthesis of (R,S)‐6H‐6‐[2‐(dimethylamino)ethoxycarbonyl]‐[6‐14C]dibenzob[b,d]pyran.HCL ([14C] FCE 20696)
Authors: Fontana Erminia , Vicario Gian Piero , Melloni Piero 
Published: October 2006

AbstractA seven steps synthesis of (R,S)‐6H‐6‐[2‐(dimethylamino) ethoxycarbonyl]‐[6‐14C]dibenzo[b,d]pyran.HCl [14C]FCE 20696 employing 9‐[9‐14C]fluorenone as labelled starting material is reported. The final product [14C] FCE 20696 was obtained in an overall radiochemical yield of 31%, 97% radiochemically pure and with a specific radioactivity of 115 MBq/mmol.
Synthesis of deuterium and tritium labelled m‐aminolevamisole and levamisole
Authors: Sangster Nicholas C. , Lacey Ernest , Than Chit , Long Mervyn A. 
Published: October 2006

AbstractLevamisole (LEV) is a widely used anti‐parasitic agent. In order to characterise the biochemical pharmacology of LEV in parasitic nematodes, [3H]LEV and a more active analogue [3H]m‐aminolevamisole (MAL) have been prepared. Labelling was accomplished by tritiated water exchange of MAL under acid conditions. Multiple site labelling was achieved in the positions ortho and para to the amino group of MAL. Tritiation of MAL HCl in [3H]2O was achieved at 103°C for 23 h. Crude [3H]MAL was diazotised (hydrochloric acid and sodium nitrite) and deaminated (hypophosphorous acid) to effect the synthesis of [3H]LEV. Products of both reactions were purified by preparative h.p.l.c. and characterised by h.p.l.c., t.l.c. and mass spectrometry. (Radiochemical yield was about 15% and purity >90%.) Specific activities of 39 Ci/mmol for [3H]MAL and 37 Ci/mmol for [3H]LEV were obtained.
Synthesis and NMR characterization of (15N)taurine [2‐(15N)aminoethanesulfonic acid]
Authors: Philippossian G. , Welti D. H. , Fumeaux R. , Richli U. , Anantharaman K. 
Published: October 2006

AbstractThe title compound was prepared in three steps with 55% overall yield starting from potassium (15N)phthalimide. The synthetic route involved reaction with 1,2‐dibromoethane, hydrolysis of the resulting N‐(2‐bromoethyl)(15N)phthalimide with HBr and treatment of the 2‐bromoethyl(15N)amine thus formed with sodium sulphite. The product was characterized by 13C, 1H and 15N NMR spectroscopy. The absolute coupling constants of 15N with the 13C nuclei and the non‐exchanging protons were determined and an unambiguous assignment of the proton signals obtained.
Synthesis of 1‐[11C]‐D,L‐homocysteine thiolactone: A potential tracer for myocardial ischemia using PET
Authors: Hamacher Kurt , Hanuš Jan 
Published: October 2006

AbstractThe synthesis of 1‐[11C]‐D,L‐homocysteine thiolactone, a potential tracer for PET imaging of ischemic heart regions, is described. The labelling is achieved by reaction of [11C]carbon dioxide with α‐lithiated S‐(tetrahydropyran‐2‐yl)3‐thiopropylisonitrile. Deprotection of the mercapto group and lactonisation of the resulting thioamino acid is accomplished in an acid catalysed reaction. The radiochemical yield obtained is 10 to 15% and the synthesis time, including the HPLC purification is about 45 min.
Microbiological preparation of 3H‐labelled methane
Authors: Sandbeck Kenneth A. , Reeburgh William S. 
Published: October 2006

AbstractSmall quantities of tritiated methane were prepared by fermenting [methyl‐3H] methylamine hydrochloride using exponential phase, transiently starved, co‐cultures of methanogenic bacteria. This method gave the expected 75% yield of C3H4 from the substrate and produced H2‐free, low 3H2O background C3H4 for tracer studies.
Synthesis of all trans [3′‐14C]menaquinone‐4
Authors: Shimada K. , Tadano K. , Satoh T. , Hashimoto K. , Tanaka S. , Yuzuriha T. 
Published: October 2006

AbstractA synthetic procedure for producing all trans [3′‐14C]menaquinone‐4 is described. The radiolabel is introduced using ethyl [3‐14C]acetoacetate as shown in the scheme. The final product has high chemical and radiochemical purity with a specific activity of 669 MBq/mmol. The overall radiochemical yield is 12%.
Carbon‐14 labelling of terbinafine, an antimycotic agent
Authors: Andres Hendrik 
Published: October 2006

AbstractTerbinafine is a new antimycotic agent which is currently being tested worldwide in clinical trials.The synthesis of [14C]Terbinafine, labelled in the naphthalene methane moiety as well as in the tertiary butyl group are described. The key step of the latter is the aluminium‐mediated tertiary butylation of an alkyne.
Mechanistic approach of the nucleophilic18F‐ exchange on 4′‐NO2‐spiperone using TBA18F or K2.2.2./K18F
Authors: Gysemans M. , Mertens J. 
Published: October 2006

AbstractHigh yield single step preparation of 4′‐18F‐spiperone by 18F‐ for NO2 exchange in highly basic conditions fails when using 4′‐NO2‐spiperone as a precursor. This compound moreover inhibits radiofluorination of highly activated molecules in mentioned conditions. Inhibition is not provoced by ketalised analogues of the butyrophenone. This led to assume that enolisation of the butyrophenone was responsible for those phenomena. The assumption is supported by the fact that the results of inhibition experiments fit to a theoretical model.
The synthesis of [1′,3′‐3H]4‐(4′‐azido‐5′,6′,7′,8′‐tetrahydro‐5′,5′,8′,8′‐tetramethyl‐2′‐anthracenyl)benzoic acid as a probe of the retinoic acid receptor
Authors: Dawson Marcia I. , Hobbs Peter D. , Dorsky Albert , Morimoto Hiromi 
Published: October 2006

AbstractThe synthesis of [1′,3′‐3H]4‐(4′‐azido‐5′,6′,7′,8′‐tetrahydro‐5′,5′,8′,8′‐tetramethyl ‐2′‐anthracenyl)benzoic acid is described. This retinoid was designed as a photoaffinity probe of the receptor sites of cellular retinoic acid‐binding protein and the nuclear retinoic acid receptor protein. The [3H]azidoretinoid was prepared from 1,2,3,4‐tetrahydro‐1,1,4,4‐tetramethyl‐7‐(4‐methylphenyl)‐5‐nitroanthracene in five steps in 15% yield (89% radiochemical purity by HPLC). 1H and 3H NMR was used to confirm the sites of 3H substitution on the ring.
Synthesis of di‐t‐alkyl nitroxides enriched in 2H and 12C
Authors: Plachy W. Z. , Viereck J. C. , Yee C. W. 
Published: October 2006

AbstractThe synthesis of a family of di‐t‐alkyl nitroxides is described, beginning with N‐t‐butyl‐2‐methyl‐2‐nitrosopropane 2H18, 12C8 (12C‐pd‐DTBN) and including molecules with 9, 10, and 11 carbons. Eliminating the proton and, in some cases, the 13C isotopes simplifies the resulting electron spin resonance (ESR) spectrum and improves the spectral resolution. Solvent dependent ESR parameters are given for this family of monofunctional spin probes. ESR evidence is seen for rotational isomerization within the most sterically hindered probe molecules. Some of these spin probes are especially useful for ESR spin probe studies in biomembranes where a range of probe hydrophobicity is desired.
The synthesis and biodistribution of 3‐(4′‐[125I]‐iodophenyl)‐4‐aminobutyric acid, a radioiodinated analogue of baclofen
Authors: Wakita Y. , Kojima M. , Schwendner S. W. , McConnell D. , Counsell R. E. 
Published: October 2006

AbstractBaclofen has been found to bind to receptors in the central nervous system that are specific for γ‐aminobutyric acid (GABA), a well known inhibitory neurotransmitter. This paper describes the synthesis of a radioiodinated analog of baclofen as part of an effort to develop receptor probes useful in single photon emission computed tomography. Preliminary biodistribution studies showed the radioiodinationed analog to be essentially stable to in vivo deiodination and have a distribution profile similar to that of baclofen.
Synthesis of carbon‐14 labeled leukotriene antagonist SK&F 104353
Authors: Shu Arthur Y. L. , Villani Anthony J. , Richard Heys J. 
Published: October 2006

AbstractEnantiomerically pure (2S,3R)‐3‐[(2‐carboxyethyl)thio]‐3‐[2‐(8‐phenyloctyl)phenyl]‐2‐hydroxy[2‐14C]propionic acid ([14C]SK&F 104353) was synthesized from methyl chloro[2‐14C]acetate via a five step sequence. Darzens Condensation with 2‐(8‐phenyloctyl)benzaldehyde gave a trans epoxy ester which underwent epoxide opening with methyl 3‐mercaptopropionate to furnish a pair of regioisomers. The desired isomer was isolated by subjecting the mixture to retroaldol cleavage conditions to remove the unwanted component. Subsequent optical resolution as a derivative of (S)‐proline and hydrolysis of the 2S,3R diastereomer afforded the title compound with a 5% overall radiochemical yield.
An efficient synthesis of the crustacean hormone [12‐3H]‐methyl farnesoate and its photolabile analog [13‐3H]‐farnesyl diazomethyl ketone
Authors: Ujváry István , Prestwich Glenn D. 
Published: October 2006

AbstractTritium‐labelled methyl farnesoate ([3H]‐MF, 6.6 Ci/mmol) was prepared from a tritiated allylic alcohol derivative by an efficient new one‐pot halogen exchange‐reductive dehalogenation sequence. The resulting [3H]‐MF was converted in three steps to a diazomethyl ketone analog, [3H]‐FDK, which can be used for the photoaffinity labelling of MF binding proteins.
Syntheses of carbon‐13 and carbon‐14 labeled (methylenecyclopropyl)acetyl‐CoA
Authors: Baldwin John E. , Widdison Wayne C. 
Published: October 2006

AbstractMethylenecyclopropyllithium reacts with 13C‐ or 14C‐oxirane to give labeled 2‐(methylenecyclopropyl)ethanol, which may be converted in three steps to the corresponding coenzyme A thioesters of (methylenecyclopropyl)acetic acid.
Synthesis and radioiodination of a meso‐tetra (hydroxynaphthyl) porphyrin and its sulphonated derivative as potential tumour localizers
Authors: Kaelin A C , Zanelli G D 
Published: October 2006

AbstractThe synthesis and radiolabelling with iodine‐125 of a sulphonated and non‐sulphonated meso‐tetra(hydroxynaphthyl) porphyrin is described. Complete demethylation of the meso‐tetra (methoxynaphthyl) porphyrin precursor to form the corresponding hydroxynaphthyl derivative could not be achieved using HBr. Sulphonation and radioiodination reactions were thus carried out on a mixture of hydroxy/methoxynaphthyl porphyrins. The weak mass spectrum exhibited by the sulphonated porphyrin derivative may reflect the highly polar nature of the compound. Neither of the iodinated porphyrins were found to localize in tumour tissue to any appreciable extent. Spleen uptake of the iodinated hydroxynaphthyl porphyrin was found to be much greater in tumour bearing mice than in normal (non‐tumour bearing) mice. This may be a result of porphyrin aggregation due to its limited water solubility.
One step conversion of glutarimide‐2,6‐14C to pentachloropyridine‐2,6‐14C and its subsequent use in the synthesis of 2‐octyl (4‐amino‐3,5‐dichloro‐6‐fluoro‐2‐pyridinyloxy‐2,6‐14C)acetate
Authors: McKendry L. H. 
Published: October 2006

AbstractA convenient method of preparing 2‐octyl (4‐amino‐3,5‐dichloro‐6‐fluoro‐2‐pyridinyloxy‐2,6‐14C)acetate from glutarimide‐2,6‐14C is described. The process includes a novel one‐step conversion of glutarimide‐2,6‐14C to pentachloropyridine‐2,6‐14C.
Synthesis of 1‐ and 3‐11C‐labelled L‐lactic acid using multi‐enzyme catalysis
Authors: Bjurling Peter , Långström Bengt 
Published: October 2006

AbstractThe synthesis of 1‐ and 3‐11C‐labelled L‐lactic acid from the corresponding racemic 1‐ or 3‐11C‐labelled alanine using a multi‐enzymatic reaction route, is presented. DL‐[1‐11C]Alanine was synthesised by reacting sodium 1‐hydroxy‐ethyl sulfite with hydrogen [11C]cyanide, obtained from [11C]carbon dioxide, and ammonia followed by acid hydrolysis. DL‐[3‐11C]‐Alanine was synthesised by a methylation of a glycine derivative, N‐(diphenylmethylene)‐glycine tert‐butyl ester, with [11C]methyl iodide, obtained from [11C]carbon dioxide, and subsequent hydrolysis. The racemic 1‐ or 3‐11C‐labelled alanine was then converted to pyruvic acid, by D‐amino acid oxidase/catalase and glutamic‐pyruvic transaminase, which was directly reduced to L‐lactic acid by L‐lactic dehydrogenase in a one‐pot procedure. The total synthesis time was 40 minutes, counted from release of [11C]carbon dioxide. The decay corrected radiochemical yields were ca. 80% for L‐[1‐11C]lactic acid, based on hydrogen cyanide, and ca. 60% for L‐[3‐11C]lactic acid, based on carbon dioxide. The radiochemical purities were higher than 99% analysed by HPLC.
Synthesis of 13C‐enriched and 14C‐labelled dithiopyr
Authors: Mehrsheikh Mohammad E. , Clizbe Lane A. , Singh Harbhajan , Purdum Wr 
Published: October 2006

AbstractThis report describes the synthesis of the 13C‐enriched and 14C‐labelled title compound starting from isotopically labelled isovaleraldehyde.
Synthesis of tetramethylethylenedioxydi‐[14c]‐methylsilane
Authors: Vidal Alain , Joachim Francis , Papirer Eugène 
Published: October 2006

AbstractThe synthesis of tetramethylethylenedioxydi‐[14C]‐methylsilane, a molecule used as a plasticizer in polysiloxane/silica blends, is described. This compound was synthesized in a 48% overall radiochemical yield from [14C]‐methyl iodide and with a specific radioactivity of 33 μCi/mmole. It was used to study the competitivity of adsorption of plasticizers and models of polydimethylsiloxanes towards silicas.
Iron‐59 labelled sodium nitroprusside
Authors: Bates J. N. 
Published: October 2006

AbstractSodium nitroprusside, a potent vasodilator in man, is synthesized with the gamma‐emitting isotope 59Fe in a single‐step synthesis from potassium cyanide, sodium nitrite, and ferrous chloride. It is purified by anion exchange chromatography and assayed by ion‐pair high pressure liquid chromatography. 14C‐nitroprusside is prepared by the same methods.
Synthesis and radioiodination of ten aryl‐carbohydrate compounds for labeling monoclonal antibodies
Authors: Warren S. D. , Ali S. A. , Richter K. Y. , Krohn K. A. 
Published: October 2006

AbstractTen aryl‐carbohydrate ligands have been synthesized that potentially increase the tumor retention and decrease the deiodination of iodinated monoclonal antibodies used in the imaging and treatment of cancer. The compounds were synthesized via reductive amination reactions, purified with cation exchange chromatography, and characterized using 1H and 13C NMR. These compounds were then radioiodinated to assess their iodination characteristics, for subsequent experiments involving attachment to monoclonal antibodies.