bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consensus Guidelines for Oral Dosing of Primarily Renally Cleared Medications in Older Adults
Authors: Hanlon Joseph T. , Aspinall Sherrie L. , Semla Todd P. , Weisbord Steven D. , Fried Linda F. , Good C. Bernie , Fine Michael J. , Stone Roslyn A. , Pugh Mary Jo V. , Rossi Michelle I. , Handler Steven M. 
Published: December 2008

OBJECTIVES: To establish consensus oral dosing guidelines for primarily renally cleared medications prescribed for older adults.DESIGN: Literature search followed by a two‐round modified Delphi survey.SETTING: A nationally representative survey of experts in geriatric clinical pharmacy.PARTICIPANTS: Eleven geriatric clinical pharmacists.MEASUREMENTS: After a comprehensive literature search and review by an investigative group of six physicians (2 general internal medicine, 2 nephrology, 2 geriatrics), 43 dosing recommendations for 30 medications at various levels of renal function were created. The expert panel rated its agreement with each of these 43 dosing recommendations using a 5‐point Likert scale (1=strongly disagree to 5=strongly agree). Recommendation‐specific means and 95% confidence intervals were estimated. Consensus was defined as a lower 95% confidence limit of greater than 4.0 for the recommendation‐specific mean score.RESULTS: The response rate was 81.8% (9/11) for the first round. All respondents who completed the first round also completed the second round. The expert panel reached consensus on 26 recommendations involving 18 (60%) medications. For 10 medications (chlorpropamide, colchicine, cotrimoxazole, glyburide, meperidine, nitrofurantoin, probenecid, propoxyphene, spironolactone, and triamterene), the consensus recommendation was not to use the medication in older adults below a specified level of renal function (e.g., creatinine clearance <30 mL/min). For the remaining eight medications (acyclovir, amantadine, ciprofloxacin, gabapentin, memantine, ranitidine, rimantadine, and valacyclovir), specific recommendations for dose reduction or interval extension were made.CONCLUSION: An expert panel of geriatric clinical pharmacists was able to reach consensus agreement on a number of oral medications that are primarily renally cleared.
Cost‐Effectiveness of Increasing Access to Mammography Through Mobile Mammography for Older Women
Authors: Naeim Arash , Keeler Emmett , Bassett Lawrence W. , Parikh Jay , Bastani Roshan , Reuben David B. 
Published: December 2008

OBJECTIVES: To compare the costs of mobile and stationary mammography and examine the incremental cost‐effectiveness of using mobile mammography to increase screening rates.DESIGN: A cost‐effectiveness analysis was performed using effectiveness data from a randomized clinical trial and modeling of costs associated with the mobile mammography intervention.SETTING: The trial involved 60 community‐based meal sites, senior centers, and clubs.PARTICIPANTS: Four hundred ninety‐nine individuals were enrolled in the study, of whom 463 had outcome data available for analysis.MEASUREMENTS: Costs were calculated for stationary and mobile mammography, as well as costs due to differences in technology and film versus digital. Incremental cost‐effectiveness (cost per additional screen) was modeled, and sensitivity analysis was performed by altering efficiency (throughput) and effectiveness based on subgroup data from the randomized trial.RESULTS: The estimated annual costs were $435,162 for a stationary unit, $539,052 for a mobile film unit, and $456, 392 for a mobile digital unit. Assuming mobile units are less efficient (50% annual volume), the cost per screen was $41 for a stationary unit, $86 for a mobile film unit, and $102 for a mobile digital unit. The incremental cost per additional screen were $207 for a mobile film unit and $264 for a mobile digital unit over a stationary unit.CONCLUSION: Although mobile mammography is a more effective way to screen older women, the absolute cost per screen of mobile units is higher, whereas the reimbursement is no different. Financial barriers may impede the widespread use of this approach.
A novel KEL*1,3 allele with weak Kell antigen expression confirming the cis‐modifier effect of KEL3
Authors: Körmöczi Günther F. , Scharberg Erwin A. , Gassner Christoph 
Published: December 2008

BACKGROUND: KEL1 (K) is the most immunogenic red blood cell antigen of the Kell blood group system. The frequently occurring anti‐KEL1 alloantibodies may cause hemolytic transfusion reactions as well as severe hemolytic disease of the fetus and newborn. So far, reports on weak KEL phenotypes are scarce.STUDY DESIGN AND METHODS: Blood samples of two unrelated Central European propositi with faint reactions in routine KEL1 typing were analyzed by extended serologic phenotyping, flow cytometry, genotyping by polymerase chain reaction with sequence‐specific priming, and genomic DNA sequencing of separated parental KEL alleles.RESULTS: Both propositi exhibited an unusual KEL:1,2,3,4 phenotype: markedly weakened and negative reactions were observed in serologic KEL1 typing in gel and tube technique, respectively. No KEL1 epitope loss was detected using five different monoclonal anti‐KEL1 reagents. KEL genotyping confirmed KEL*1/2 and KEL*3/4 (Kpa/Kpb) heterozygosity of both individuals. Importantly, DNA sequencing of the two separated parental alleles of both propositi revealed a KEL*1‐specific coding nucleotide T578 and a KEL*3‐specific T841 on the same allele. This novel KEL*1,3 (KKpa) allele was associated with an approximately 80 percent reduction in KEL1 expression, compared to KEL:1,2, –3,4 controls. The low KEL1 density was attributed to a cis‐modifier effect of KEL3, so far only reported in association with weakened expression of KEL2 (k).CONCLUSION: This is the first description of the KEL*1,3 allele encoding KEL1 and KEL3 on the same molecule. In individuals with weakened KEL1 because of KEL3 in cis, very sensitive serologic or molecular genetic techniques may be required for reliable Kell typing.
X‐Teams: How To Build Teams That Lead, Innovate, and Succeed by Deborah Ancona and Henrik Bresman
Authors: Castellion George 
Published: December 2008

I am retiring from the profession and from this position as your book review editor; the very capable Donovan Hardenbrook will be your next editor. I think we have worked out a seamless transition, but Donovan will doubtless bring his energy and innovation to the position.These nearly five years as editor have been a lot of work but a great deal of satisfaction too. This position is the best one in the world for keeping on top of the newest thinking in product development, for being able to see the latest books as—or even before—they are published, and for learning by editing the work of knowledgeable reviewers critically.Some statistics: In nearly five years, we received 560 books for review, reviewed 144 of them, processed 659 review drafts, and discarded about 430 books (mostly to The Prisoners Literature Project). A more modern metric: I received 3,372 e‐mails about book reviews (and probably sent a similar number).Of course, I've had much help, which I would like to acknowledge. Tony Di Benedetto, the journal editor, was a constant source of encouragement and support, and Beebe Nelson, the former book review editor, backed me up. Our 41 active reviewers did the real work, and some of them are prolific reviewers: Mark Hart, George Castellion, Ruediger Klein, and Gerald Mulenburg each reviewed 10 or more books. Kristi Bennett, our copyeditor, has done a wonderful job of ensuring the consistency of these offerings. Finally, we are indebted to about 70 book publishers (technically, imprints) that supplied the review copies gratis.Books reviewed in this issue:

X‐Teams: How To Build Teams That Lead, Innovate, and Succeed
Edison on Innovation: 102 Lessons in Creativity for Business and Beyond
Something Really New: Three Simple Steps to Creating Truly Innovative Products
Smart Isn't Enough: Lessons from a Work Performance Coach
The Power of Mobility: How Your Business Can Compete and Win in the Next Technology Revolution
Measurement Equivalence Using Generalizability Theory: An Examination of Manufacturing Flexibility Dimensions
Authors: Malhotra Manoj K. , Sharma Subhash 
Published: December 2008

ABSTRACTAs the field of decision sciences in general and operations management in particular has matured from theory building to theory testing over the past two decades, it has witnessed an explosion in empirical research. Much of this work is anchored in survey‐based methodologies in which data are collected from the field in the form of scale items that are then analyzed to measure latent unobservable constructs. It is important to assess the invariance of scales across groups in order to reach valid, scientifically sound conclusions. Because studies have often been conducted in the field of decision sciences with small sample sizes, it further exacerbates the problem of reaching incorrect conclusions. Generalizability theory can more effectively test for measurement equivalence in the presence of small sample sizes than the confirmatory factor analysis (CFA) tests that have been conventionally used for assessing measurement equivalency across groups. Consequently, we introduce and explain the generalizability theory (G‐theory) in this article to examine measurement equivalence of 24 manufacturing flexibility dimension scales that have been published in prior literature and also compare and contrast G‐theory with CFA. We show that all the manufacturing flexibility scales tested in this study were invariant across the three industry SIC groups from which data were collected. We strongly recommend that G‐theory should always be used for determining measurement equivalence in empirical survey‐based studies. In addition, because using G‐theory alone does not always reveal the complete picture, CFA techniques for establishing measurement equivalence should also be invoked when sample sizes are large enough to do so. Implications of G‐theory for practice and its future use in operations management and decision sciences research are also presented.
Information Technology and Process Performance: An Empirical Investigation of the Interaction Between IT and Non‐IT Resources*
Authors: Jeffers Patrick I. , Muhanna Waleed A. , Nault Barrie R. 
Published: December 2008

ABSTRACTDrawing on the resource‐based view, we propose a configurational perspective of how information technology (IT) assets and capabilities affect firm performance. Our premise is that IT assets and IT managerial capabilities are components in organizational design, and as such, their impact can only be understood by taking into consideration the interactions between those IT assets and capabilities and other non‐IT components. We develop and test a model that assesses the impact of explicit and tacit IT resources by examining their interactions with two non‐IT resources (open communication and business work practices). Our analysis of data collected from a sample of firms in the third‐party logistics industry supports the proposed configurational perspective, showing that IT resources can either enhance (complement) or suppress (by substituting for) the effects of non‐IT resources on process performance. More specifically, we find evidence of complementarities between shared business–IT knowledge and business work practice and between the scope of IT applications and an open communication culture in affecting the performance of the customer‐service process; but there is evidence of substitutability between shared knowledge and open communications. For decision making, our results reinforce the need to account for all dimensions of possible interaction between IT and non‐IT resources when evaluating IT investments.
RFID as an Enabler of Improved Manufacturing Performance*
Authors: Hozak Kurt , Collier David A. 
Published: December 2008

ABSTRACTThe use of radio frequency identification (RFID) versus bar coding has been debated with little quantitative research about how to best use RFID's capabilities and when RFID is more advantageous. This article responds to that need by qualitatively and quantitatively analyzing how RFID facilitates increased traceability and control in manufacturing, which in turn enables the use of more lot splitting and smaller lot sizes. We develop insights about operating policies (RFID vs. bar‐code tracking mechanisms, extent of lot splitting, and dispatching rules) and an operating condition (setup to processing time ratio) that affect the mean flow time and proportion of jobs tardy in a job shop. A simulation model is used to control factors in the experimental design and the output is evaluated using analysis of variance. The results show the following: (i) performance worsens when bar coding is used with extensive lot splitting, (ii) process changes such as extensive lot splitting may be required to justify RFID use instead of bar coding, (iii) the earliest operation due date dispatching rule offers an attractive alternative to other rules studied in previous lot splitting research, and (iv) the performance improvements with RFID and increased lot splitting are larger when the setup to processing time ratio is smaller. In a broader context, we fill a research void by quantitatively showing how RFID can be used as an advanced manufacturing technology that enables more factory automation and better performance along several dimensions. The article concludes by summarizing the results and identifying ideas for future research.
Influence of microgroove dimension on cell behavior of human gingival fibroblasts cultured on titanium substrata
Authors: Lee Suk‐Won , Kim Su‐Yeon , Rhyu In‐Chul , Chung Won‐Yoon , Leesungbok Richard , Lee Keun‐Woo 
Published: December 2008

Abstract:Objective: The purpose of this study was to determine the dimension of surface microgrooves on titanium (Ti) substrata that shows the greatest positive influence on characterizing specific cell behavior of cultured human gingival fibroblasts.Material and methods: Commercially pure Ti disks with surface microgrooves of monotonous 3.5 μm in depth and respective 15, 30, and 60 μm in width were fabricated using photolithography and used as the culture substrata in the three experimental groups in this study (TiD15, TiD30, and TiD60 groups), whereas the smooth Ti disk was used as the control substrata (smooth Ti group). Human gingival fibroblasts were cultured on the four groups of Ti substrata on successive timelines. Cell behaviors, such as adhesion, morphology, viability and proliferation, and gene expression were analyzed and compared between all groups using crystal violet stain, scanning electron microscopy (SEM), XTT assay, and reverse transcriptase‐polymerase chain reaction, respectively.Results: SEM demonstrated that cells were able to readily descend into the microgrooves of TiD30 at the early phase of culture. Cells on the ridge edges or in groove corners were spindle shaped with abundant filopodia formation toward the acid‐etched surface inside the microgrooves, thus mimicked the cell shape in three‐dimensional (3D) nanoenvironment. TiD15 significantly increased the cell viability and proliferation compared with the smooth Ti substrata after 72 h of culture. Up‐regulation of fibronectin (FN) and α5 integrin genes was noted in cells cultured on TiD15 and TiD30. Gene expression pattern specific to the cells in 3D‐matrix culture, such as down‐regulation of α‐smooth muscle actin gene along with up‐regulation of FN and p21 genes, was pronounced in cells cultured on TiD30.Conclusion: This study indicates that surface microgrooves of both 15 and 30 μm in width and a monotonous 3.5 μm in depth on Ti substrata increase various cell behaviors of cultured human gingival fibroblasts.
Bone formation with various bone graft substitutes in critical‐sized rat calvarial defect
Authors: Park Jin‐Woo , Jang Je‐Hee , Bae Sang‐Ryul , An Chang‐Hyeon , Suh Jo‐Young 
Published: December 2008

AbstractObjective: This histomorphometric study compared the efficacy of a new bone graft substitute (N‐HA) derived from hen eggshell, consisted of submicron scale porous hydroxyapatite structure, in the healing of 8 mm diameter critical size defects in rat calvaria. We compared N‐HA alone or in combination with calcium sulfate (CS), with a commercial bone substitute, anorganic bovine bone (Bio‐Oss, BO).Material and methods: Critical size defects were created in calvaria of 56 adult Sprague–Dawley rats. Animals were divided into four groups and treated with (1) unfilled defects, (2) N‐HA grafts, (3) BO grafts and (4) N‐HA/CS grafts. The percentage of new bone formed (NB%) was evaluated histomorphometrically after 6 and 12 weeks.Results: The N‐HA group exhibited more new bone formation compared with other groups at 6 and 12 weeks. Histomorphometric analysis showed greater NB% in N‐HA group (11.2% at 4 weeks and 19.2% at 12 weeks) compared with those in unfilled (3.9% at 6 weeks and 6.4% at 12 weeks), BO‐treated (6.4% at 6 weeks and 8.2% at 12 weeks) and N‐HA/CS‐treated (6.3% at 6 weeks and 12.6% at 12 weeks) groups. The N‐HA group showed significant differences in NB% compared with unfilled group at 6 weeks (P=0.016), unfilled and BO‐treated groups at 12 weeks (P=0.001). The addition of CS did not enhance the NB% compared with defects grafted with N‐HA alone.Conclusion: N‐HA was an osteoconductive bone substitute for treating osseous defects in critical size defects of rat calvaria.
Systemic tetracycline delays degradation of three different collagen membranes in rat calvaria
Authors: Moses Ofer , Shemesh Avi , Aboodi Guy , Tal Haim , Weinreb Miron , Nemcovsky Carlos E. 
Published: December 2008

AbstractObjectives: The aim of this study was to quantitatively evaluate the effect of systemic tetracycline (TTC) on the degradation of three different collagen membranes.Materials and methods: Collagen membranes were cut into 5 mm diameter membrane discs and labeled with aminohexanoyl‐biotin‐N‐hydroxy‐succinimide ester. One membrane disc each of a non‐cross‐linked [BioGide® (BG)], glutaraldehyde cross‐linked [BioMend Extend® (BM)], and ribose cross‐linked [Ossix™ (OS)] was implanted on the calvaria of 40 Wistar rats. Another 10 biotinylated collagen membrane discs from each membrane type were processed for histologic observation and served as baseline; half of them (five from each group) were also treated with formic acid to inspect possible interference with biotinilazation of collagen by formic acid used during the decalcification process. A 10 mg/kg dose of TTC (50% of the minimal recommended antibacterial dose) to the experimental (20 animals) and saline to the control (20 animals) group was administered intramuscularly every 3 days. From each group, block sections were retrieved in half of the animals after 14 days and in the remaining after 28 days. Decalcified tissue histology was stained with streptavidin horseradish peroxidase. A computer‐assisted program measured the membranes' collagen contents. Statistical analysis consisted of analysis of variance (ANOVA) with repeated measures.Results: No statistically significant differences in collagen contents were appreciated between biotinylated non‐implanted membranes treated or not treated by formic acid. Systemic TTC had a different effect on the bio‐degradation of the membranes: while it significantly decreased the resorption of two of the membranes (BG and BM), it had minimal influence on the ribose cross‐linked membrane (OS). ANOVA with repeated measures, tests of within‐subjects effects, showed a statistically significant difference between the membranes (P<0.001), within the membranes at the different time‐points (P<0.001), a significant interaction between membranes and time and between the membranes and administered TTC (P<0.001). Test of between‐subject effects revealed a statistically significant interaction with time and with TTC (P<0.001).Conclusions: Systemically administered TTC in sub‐antibacterial doses may offer a possible treatment alternative to reduce bio‐degradation and enhance bio‐durability of certain collagen membranes. The findings of the present study could have clinical application in large non‐self‐contained bone defects, where prolonged membrane barrier functions are desirable.
ORIGINAL ARTICLE: Genistein Reverses Diminished T‐Cell Signal Transduction, Induced by Post‐Menopausal Estrogen Levels
Authors: Parry J. Preston , Taylor Douglas D. , Nakajima Steven T. , Gercel‐Taylor Cicek 
Published: December 2008

Problem  This study addressed the ability of genistein to reverse the loss of T‐cell signaling components, induced by estrogen deficiency associated with aging.Method of study  Using Jurkat 6.1 T cells, genistein regulation of CD3ζ, JAK3, and NFκB was analysed by Western immunoblotting at 4 or 40 pg/mL (post‐ and pre‐menopausal levels, respectively) estradiol (E2). Corresponding gene expressions were quantified by real‐time polymerase chain reaction (RT‐PCR). For functionality, levels of IL‐2 were correlated with its transcription by RT‐PCR.Results  At 4 pg/mL E2, signaling proteins were decreased compared with 40 pg/mL: CD3ζ, 1.58‐fold; JAK3, 1.75‐fold; and NFκB, 1.73‐fold (P < 0.001). Genistein, at 0.5 and 5.0 μm, added to 4 pg/mL E2 induced their expression to 40 pg/mL levels. While significantly diminished IL‐2 mRNA levels were observed at 4 pg/mL E2, genistein induced IL‐2 mRNA to 40 pg/mL levels.Conclusion  Genistein restores CD3ζ, NFκB and JAK3 proteins and mRNAs at post‐meonopausal estrogen levels, in vitro, with no significant effect at pre‐menopausal estrogen levels.
ORIGINAL ARTICLE: Mifepristone as an Anti‐Implantation Contraceptive Drug: Roles in Regulation of Uterine Natural Killer Cells during Implantation Phase
Authors: Zhu Hong‐Xia , Zhang Wu‐Wen , Zhuang Ya‐Ling , Huang Li‐Li 
Published: December 2008

Problem  To investigate the immunological mechanism of low‐dose mifepristone acting as a contraceptive at the level of the endometrium.Method of study  Endometrial explants were cultured in vitro with or without mifepristone treatment for 24 hr. Some tissues were fixed and immunostained for CD56, while other tissues were dissociated and cells analysed by three colour flow cytometry for CD3, CD56 and CD16.Results and conclusion  Results showed a significant increase in the number of CD56+ natural killer (NK) cells and the percentages of CD3− CD56+ CD16− NK cell subset in the tissue treated with mifepristone, while the percentage of CD3− CD56+ CD16+ NK cell subset remained unaffected. It shows that low‐dose mifepristone increases the number of CD56+ NK cells and the percentage of CD3− CD56+ CD16− NK subset in receptive endometrium and provides new insights into the immunological mechanism of low‐dose mifepristone as an anti‐implantation contraceptive drug.