bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between blood urea nitrogen to albumin ratio and the 28-day all-cause mortality in tuberculosis patients complicated by sepsis: a retrospective cohort study
Authors: Cui Kunping , Feng Shuang , Mao Yi , Luo Haixia , Yang Jiao , Xu Ruyi , Bai Lang 
Published: February 2024

Abstract

Objective
The relationship between blood urea nitrogen to albumin ratio (BAR) and the prognosis of patients with tuberculosis (TB) complicated by sepsis remains unclear. This study aimed to explore the association between BAR and overall patient prognosis.
Methods
This was a retrospective cohort study of patients with TB complicated by sepsis who were admitted to the intensive care unit (ICU) of the Public Health Clinical Center of Chengdu between January 2019 and February 2023. The relationship between BAR values and prognosis in these patients was investigated using multivariate Cox regression, stratified analysis with interaction, restricted cubic spline (RCS), and threshold effect analysis. Sensitivity analyses were conducted to assess the robustness of the results.
Results
Our study included 537 TB patients complicated by sepsis admitted in the ICU, with a median age of 63.0 (48.0, 72.0) years; 76.7% of whom were men. The multivariate-restricted cubic spline analysis showed a non-linear association between BAR and patient prognosis. In the threshold analysis, we found that TB patients complicated by sepsis and a BAR < 10.168 mg/g had an adjusted hazard ratio (HR) for prognosis of 1.126 (95% CI, 1.066–1.188; P < 0.001). However, when the BAR was ≥ 10.168 mg/g, there was no significant increase in the risk of death. The results of the sensitivity analysis were stable.
Conclusion
A non-linear relationship between BAR and prognosis was observed among patients with TB complicated by sepsis.
Body roundness index and risk of developing hypertension: A prospective cohort study in southwest China
Authors: Zhan Qingqing , Liu Tao , Wang Yiying , An Qinyu , Zhang Fuyan , Zhang Tianlin 
Published: February 2024

Abstract

Background
Body roundness index (BRI) is an obesity-related anthropometric index that combines waist circumference (WC) and height to better reflect body fat. This study aims to prospectively explore the relationship between BRI and the risk of hypertension based on a population cohort of the Chinese Western region.
Methods
The study data came from a natural population cohort of Guizhou province established in 2010, and a total of 9,280 people in 48 townships in 12 districts (counties) were surveyed at baseline using multistage stratified randomized whole cluster sampling. Follow-up surveys were completed from 2016 to 2020, and after excluding deaths, lost visits, baseline hypertension, unclear follow-up hypertension diagnosis, and missing relevant variables, a final 5,230 people entered the analysis. Cox proportional risk models were used to analyze the association between BRI and the development of hypertension and to calculate hazard ratios (HRs) and 95% CIs. Analyzing the relationship between BRI and time to onset of hypertension using the time failure acceleration model.
Results
The total person-years (PYs) of follow-up were 36,950.24 years, with a median follow-up time of 6.64 years. During the follow-up period 1157 study subjects developed new hypertension with an incidence density of 31.31/1000 PYs. After adjusting for confounding variables, BRI increased the risk of hypertension by 17% per unit increase (HR = 1.17,95% CI: 1.108–1.235, P trend < 0.001). Compared with the population in the first quartile (Q1) of BRI, the risk of hypertension in the population in the third quartile (Q3) and fourth quartile (Q4) is 1.309 (95% CI: 1.1-1.558) and 1.534 (95% CI: 1.282–1.837), respectively. For each unit increase in BRI, the onset of hypertension is advanced by 0.255 years (95% CI: -0.348-0.162).
Conclusion
There is a significant correlation between elevated body mass index (BRI) and an increased propensity for hypertension, BRI could serve as a valuable instrument for weight management among individuals already diagnosed with hypertension.
Computational investigation of the functional landscape of the protective role that Extra Virgin Olive Oil consumption may have on Chronic Lymphocytic Leukemia
Authors: Bourdakou Marilena M. , Melliou Eleni , Magiatis Prokopios , Spyrou George M. 
Published: February 2024

Abstract

Background: The health benefits of the Mediterranean diet are partially attributed to the polyphenols present in extra virgin olive oil (EVOO), which have been shown to have anti-cancer properties. However, the possible effect that EVOO could have on Chronic Lymphocytic Leukemia (CLL) has not been fully explored.
Methods: This study investigates the anti-CLL activity of EVOO through a computational multi-level data analysis procedure, focusing on the identification of shared biological functions between them. Specifically, publicly available data from genomics, transcriptomics and proteomics related to EVOO consumption and CLL were collected from several resources and analyzed through a computational pipeline, highlighting common molecular mechanisms and biological processes. Computational verification of a number of the highlighted functional terms associating CLL and EVOO has been performed as well.
Results: Our investigation revealed four molecular pathways and three biological processes that overlap between mechanisms associated with CLL and those impacted by the consumption of EVOO. To further investigate the common biological functions, we focused on AKT1-related terms, aiming to investigate the potential importance of AKT1 in the anti- CLL effects associated with EVOO.
Conclusions: Overall, the results provide valuable insights into the potential beneficial effect of EVOO in CLL and highlight EVOO’s bioactive compounds as promising candidates for future investigations.
Association of the Previne Brasil Program in prenatal care and maternal-child mortality
Authors: Arato Caio Vieira de Barros , Probst Livia Fernandes , Guerra Luciane Miranda , Pereira Antonio Carlos 
Published: February 2024

Abstract

Background: Brazil has witnessed a significant reduction in maternal-child mortality with the establishment of the Unified Health System. However, the rates remain high and should be mitigated through effective public policies that comprehend the factors involved in these elevated rates.
Objective: To investigate the impact of prenatal care on the reduction of maternal-child mortality in Brazilian municipalities following the new financing model of Primary Health Care, the Previne Brasil program.
Methods: This study comprised a nationwide cross-sectional observational analysis, utilizing secondary data from the Brazilian public health system. Medians of maternal mortality, infant mortality, and prenatal care rates were calculated for Brazilian municipalities from 2016 to 2022. Logistic regression analyses were conducted to assess associations between independent variables (primary care coverage, population, Gross Domestic Product, and Gini index) and outcomes (variation in maternal and infant death rates). Raw and adjusted odds ratios were estimated, with a significance level set at 5%.
Results: Prenatal care rates increased by 86.7%, while maternal death rates decreased by 30.9%, with no significant association between them (p>0.05). Region, primary care coverage, municipal GDP, and population showed significant associations (p<0.05) with the variation in maternal death rates. The Southern region had a higher chance of reducing maternal death rates. No significant association was found between an increase in prenatal care rates and a decrease in infant death rates (p>0.05). The country's region, primary care coverage, population, and Gini index were significantly associated (p<0.05) with the variation in infant death rates, with a greater chance of reduction in more populous municipalities and in the Northeast, Southeast, and Midwest regions.
Conclusion: The Previne Brasil Program led to an increase in prenatal care consultations in Brazilian municipalities but did not significantly impact the reduction of maternal-child mortality.
Design and Characterization of Gelatin-Coated Upconversion Nanoparticles: Insights into Structural, Relaxometric, Luminescent, and Cytotoxic Properties
Authors: de Lima Joyce Francine da Silva , Oliveira Giovanna Nogueira da Silva Avelino , Santos Dayane Kelly Dias do Nascimento , Pereira Giovannia Araújo de Lima , Viana Rodrigo da Silva , Junior Severino Alves 
Published: February 2024

Abstract

T he present study aimed to develop a theranostic nanoprobe for application. This nanoprobe is composed of upconversion nanoparticles (NPs) coated with gelatin. Initially, erbium-ytterbium co-doped gadolinium oxide (Gd2O3:Yb/Er) was synthesized using the homogeneous precipitation technique. The Gd2O3:Yb/Er particles were coated with gelatin (Gd2O3:Yb/Er@Gelatin) using the desolvation method. Four syntheses were conducted with different gelatin concentrations and the use of glutaraldehyde (GA) as a cross-linking agent. The characterization of the nanoprobe included structural, relaxometric, luminescent, and cytotoxicity analyses. The results indicate that cross-linking with GA reduces the size of the NPs, suggesting a greater compaction of the gelatin chains. It was observed that the gelatin coating increases the concentration of water molecules near the NPs through hydrogen bonding interactions and modulates their diffusion time near the paramagnetic center, influencing the decrease in proton relaxation time. On the other hand, cross-linking with GA restricts the mobility of water molecules, by all relaxivity values were found to be higher than those of commercial contrast agents. The luminescent data showed that although the spectral emission profile of upconversion between Yb3+ and Er3+ ions did not change compared to the oxide, the emission intensity ratio (IR/IG) decreased with coating, and the emission in the green region is generated by the absorption of three photons, while the emission in the red region is generated by the absorption of two photons. It was also observed that Gd2O3:Yb/Er and Gd2O3:Yb/Er@Gelatin NPs had no cytotoxic effect on healthy cells, with cell viability above 90%. The developed nanoprobe showed interesting luminescent and relaxometric properties, making it a promising tool for optical and magnetic bioimaging.
Alterations of the peptidomic composition of peripheral plasma after portal hypertension correction by transjugular intrahepatic portosystemic shunt
Authors: Bagarolo Giulia Ilaria , Bhargava Shruti , Schierwagen Robert , Gu Wenyi , Jankowski Vera , Soppert Josefin , Barzakova Emona , Cascone Federica , Tyc Olaf , Kuhl Christiane , Noels Heidi , Trebicka Jonel , Jankowski Joachim 
Published: February 2024

Abstract

Portal-hypertension develops in patients with advanced chronic liver diseases(CLD), especially cirrhosis and is associated with complications, such as gastrointestinal bleeding and ascites resulting in high mortality. The transjugular intrahepatic portosystemic shunt(TIPS) is a treatment option for portal-hypertension, aiming to decrease portal venous pressure by establishing an artificial passage for blood from the gastrointestinal tract to the liver vein. This study focuses on the differences in the molecular composition of plasma samples from patients with portal-hypertension before and after TIPS intervention to identify and characterise mediators influencing gut-liver cross-talk. The plasma of 23 patients suffering from advanced CLD with portal-hypertension was collected from peripheral veins before and after TIPS treatment and analysed using a well-established non-targeted chromatography-mass spectrometric(LC-MS) approach. Sialomucin core protein 24(CD164)(160–180), meckelin(99–118), Histone-lysine N-methyltransferase(MLL3)(3019–3045) and transient receptor potential cation channel subfamily V member 5(TRPV5)(614–630) were identified to be downregulated after the TIPS treatment. In addition, the metabolites 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid(CMPF), uric acid, Dopamine, homoarginine, leucylproline and 5-methyluridine were significantly decreased after TIPS, whereas one yet unidentified low molecular-weight metabolite showed an increase after the medical procedure. In conclusion, these substances are novel biomarkers for portal-hypertension in patients with CLD, with mechanistic clues of involvement in regulating pathological gut-liver cross-talk.
KIF18A is a novel target of JNK1/c-Jun signaling pathway involved in tumorigenesis
Authors: Wang Yajie , Yu Siqi , Huang Baihai , Zhou Bowen , Wu Xinyue , Lian Xiaoying , Wen Lianpu , Zhu Changjun 
Published: February 2024

Abstract

Background
The mitogen-activated protein kinases (MAPKs) play a crucial role in various cellular processes, including gene expression. Among these, MAPK, MAPK8 (JNK1) specifically activates the oncogene—c-Jun. KIF18A, a kinesin protein, functions both as a promoter and an inhibitor of microtubule dynamics. Aberrant expression of KIF18A is linked with tumorigenesis, but its involvement in the JNK1/c-Jun pathway remains unclear. This study investigates the regulatory relationship between KIF18A and the JNK1-c-Jun pathway in cervical cancer.
Methods
We utilized the Genomic Data Commons (GDC) data portal to screen for KIF18A-related protein kinases in cervical cancer. All mRNA expression data of all cancer types obtained from TCGA database was investigated to further confirm the correlation between JNK1 and KIF18A. Expression levels of pc-Jun, c-Jun and KIF18A were examined through western blotting (WB) after inhibition of JNK1 in HeLa cells. In silico analysis was performed to identify the TF binding motifs on KIF18A promoter. Chromatin immunoprecipitation (ChIP) assay and Luciferase assay were used to confirm the c-Jun's direct binding and activation of the KIF18A promoter. Effect of c-Jun/KIF18A on cell growth was assessed by MTT assay and colony assay.
Results
A total of 193 kinases exhibited a close correlation with KIF18A, with JNK1 displaying a notably high correlation in cervical cancer and other tumor types. Inhibition of JNK1 in HeLa cells resulted in reduced KIF18A expression and decreased phosphorylation of c-Jun. Through In-silico analysis, c-Jun was identified as a transcription factor (TF) capable of binding to the KIF18A promoter. Confirmatory ChIP and Luciferase assays established c-Jun's direct binding and activation of the KIF18A promoter. Knockdown of c-Jun inhibited cancer cell proliferation by suppressing KIF18A transcription.
Conclusions
In summary, the JNK1/c-Jun pathway activates KIF18A expression, a process essential for cervical cancer cell proliferation. Targeting the JNK/c-Jun/KIF18A axis holds promise as a novel therapeutic approach in cancer treatment.
WITHDRAWN: Harmonizing Sustainable Transportation: A Comprehensive Hybrid Vehicle Integrating CNG, In-Wheel Motors, and Rooftop Solar Panels for Environmental Excellence.
Authors: KARTHIK MURI 
Published: February 2024

Abstract
This research paper presents a novel approach to sustainable transportation by proposing a hybrid vehicle that integrates a compressed natural gas (CNG) engine with a battery-powered plug-in electric vehicle (BEV). The hybrid system incorporates in-wheel motors for enhanced efficiency and maneuverability, coupled with a rooftop solar panel system to supplement energy supply. The integration of CNG and electric power addresses range anxiety associated with electric vehicles, reduces emissions, and promotes cleaner air quality. In-wheel motors optimize torque control and regenerative braking, while the rooftop solar panels extend the vehicle's driving range, reducing dependence on the grid. This comprehensive approach offers a promising solution for sustainable transportation, aligning with environmental goals and advancing clean energy technologies in the automotive sector
Investigating post-traumatic stress disorder among internally displaced undergraduate students in tribal districts of Pakistan
Authors: Cao Shan , Hussain Mudassir , Ullah Mati 
Published: February 2024

Abstract
The main focus of the researcher in this study was to investigate the Post-Traumatic Stress Disorder (PTSD) among Internally Displaced Undergraduate Students in Tribal Districts of Pakistan. The total number of (N = 220, respondents (IDPs undergraduate students) in six universities of Khyber Pakhtunkhwa (UST Bannu, KUST, Kohat, Gomal University, University of Peshawar, Swat University, and Malakand University) were the population of the study in which (n = 140 respondents: (20 undergraduate students) from each Tribal District (North Waaziristan South Waziristan, Orakzai, Bajaur, Kurram, Khyber and Mohmand) in the selected universities were taken as sample of the study by applying Krejcie, R.V., & Morgan, D.W. (1970) sample size formula. Simple random sampling and stratified sampling techniques were used. The key purpose of the study was to investigate the Post-Traumatic Stress Disorder among IDPs Undergraduate Students in Tribal Districts of Pakistan. Data were taken through a face-to-face questionnaire on a 3-point scale with options much affected, more affected, and most affected for quantitative purposes while interviews were taken from the respondents for qualitative purposes. The collected data were recorded and statistically analyzed through SPSS by using frequency, percentage, and Chi-Square tests. Results and conclusions were drawn by revealing that PTSD negatively affected IDPs Undergraduate students. Some recommendations were suggested that the government may give priority to discouraging and stopping war hazards in tribal districts of Pakistan by establishing psychological, medical, and psychiatric corners in each tribal district to ensure better treatment of PTSD patients.
Hepatitis E Infection and the Question of Screening Organ Donors
Authors: Solignac Justine , Boschi Celine , Pernin Vincent , Fouilloux Virginie , Motte Anne , Aherfi Sarah , Aubrespy Maxime Fabre - , Legris Tristan , Brunet Philippe Brunet , Colson Philippe , Moal Valérie 
Published: February 2024

Abstract
Background
Hepatitis E is a potentially serious infection in organ recipients, with an estimated two-thirds of cases becoming chronic, and with a subsequent risk of cirrhosis and death. In Europe, transmission occurs most often through the consumption of raw or undercooked pork, more rarely through blood transfusion, but also after solid organ transplantation. Here we describe a case of Hepatitis E virus (HEV) infection transmitted following kidney transplantation and review the literature describing cases of HEV infection transmitted by solid organ transplantation.
Case presentation
Three weeks after kidney transplantation, the patient presented with an isolated minimal increase in GGT and hepatic cytolysis 6 months later, leading to the diagnosis of genotype 3c hepatitis E, with a plasma viral load of 6.5 log10IU/mL. In retrospect, HEV RNA was detected in the patient's serum from the onset of hepatitis, and in the donor's serum on the day of donation, with 100% identity between the viral sequences, confirming donor-derived HEV infection. Hepatitis E had a chronic course, was treated by ribavirin, and relapsed 10 months after the end of treatment.
Conclusions
Seven cases of transmission of HEV by solid organ transplantation have been described since 2012 without systematic screening for donors, all diagnosed at the chronic infection stage; two patients died. HEV organ donor transmission may be underestimated and there is insufficient focus on immunocompromised patients in whom mild liver function test impairment is potentially related to hepatitis E. However, since HEV infection is potentially severe in these patients, and as evidence accumulates, we believe that systematic screening of organ donors should be implemented for deceased and living donors regardless of liver function abnormalities, as is already the case in the UK and Spain. In January 2024, the French regulatory agency of transplantation has implemented mandatory screening of organ donors for HEV RNA.
Analysis on temporal variability of monsoon rainfall using ARIMA Model and ANN-LSTM
Authors: Grover Rahul , Sharma Siddhartha , Bajaj Pankaj 
Published: February 2024

Abstract
In this study, machine learning algorithms employed for predicting the weather conditions of the upcoming day with a particular focus on forecasting rain, which serves as a crucial indicator. To identify the most reliable rain-related attributes, most of the researchers utilize line charts, matrix graphs, and scatterplot graphs for visualization and analysis. The investigation reveals several attribute pairs demonstrating a significant degree of similarity and correlation. In the modeling phase, researchers employ elementary models such as decision trees, and regression analysis to assess their fundamental prediction capabilities. The resulting accuracy rate found favourable sometimes on statistics platform. Notably, during the visualization stage, a subtle pattern emerges: samples experiencing rainfall today exhibit a slightly elevated probability of rain the following day. Temporal variability in rainfall refers to the fluctuations and changes in precipitation patterns over time. It encompasses the temporal distribution, intensity, and duration of rainfall events, reflecting the dynamic nature of weather systems. Understanding temporal variability is crucial for effective water resource management, agriculture, and climate impact assessment. Consequently, our attempt to analyze the influence of historical weather on forecasting using ARIMA and ANN-LSTM. The rainfall predictions generated by these models are deemed accurate based on statistical analysis and algorithm simulation.
Tuning the ground state of cuprate high-critical-temperature superconducting thin films by nanofaceted substrates
Authors: Seibold Goetz , Arpaia Riccardo , Wahlberg Eric , Bauch Thilo , Kalaboukhov Alexei , Caprara Sergio , Castro Carlo Di , Grilli Marco , Lombardi Floriana , Mirarchi Giovanni 
Published: February 2024

Abstract

Anisotropic transport properties have been assessed in a number of cuprate superconductors, providing evidence for a nematic state. In our recent experiment we have shown that for ultra- thin YBa2Cu3O7-δ (YBCO) films, where nematicity is induced via strain engineering, there is a suppression of charge density wave scattering along the orthorhombic a-axis and a concomitant enhancement of strange metal behavior along the b-axis~. Here we develop a microscopic model, that is based on the strong interaction between the substrate facets and the thin film, to account for the unconventional phenomenology. Based on the atomic force microscopy imaging of the substrates’ surface, the model is able to predict the absence (presence) of nematicity and the resulting transport properties in films grown on SrTiO3 (MgO) substrates. Our result paves the way to new tuning capabilities of the ground state of HTS by substrate engineering.