bluuebunny/crossref_metadata_2025_split huggingface dataset:
Groundwater quality assessment using water quality index and principal component analysis in the Achnera block, Agra district, Uttar Pradesh, Northern India
Authors: Ali Shahjad , Verma Sitaram , Agarwal Manish Baboo , Islam Raisul , Mehrotra Manu , Deolia Rajesh Kumar , Kumar Jitendra , Singh Shailendra , Mohammadi Ali Akbar , Raj Deep , Gupta Manoj Kumar , Dang Phuyen , Fattahi Mehdi 
Published: March 2024

AbstractThe qualitative and quantitative assessment of groundwater is one of the important aspects for determining the suitability of potable water. Therefore, the present study has been performed to evaluate the groundwater quality for Achhnera block in the city of Taj, Agra, India, where groundwater is an important water resource. The groundwater samples, 50 in number were collected and analyzed for major ions along with some important trace element. This study has further investigated for the applicability of groundwater quality index (GWQI), and the principal component analysis (PCA) to mark out the major geochemical solutes responsible for origin and release of geochemical solutes into the groundwater. The results confirm that, majority of the collected groundwater samples were alkaline in nature. The variation of concentration of anions in collected groundwater samples were varied in the sequence as, HCO3− > Cl− > SO42− > F−while in contrast the sequence of cations in the groundwater as Na > Ca > Mg > K. The Piper diagram demonstrated the major hydro chemical facies which were found in groundwater (sodium bicarbonate or calcium chloride type). The plot of Schoellar diagram reconfirmed that the major cations were Na+and Ca2+ions, while in contrast; major anions were bicarbonates and chloride. The results showed water quality index mostly ranged between 105 and 185, hence, the study area fell in the category of unsuitable for drinking purpose category. The PCA showed pH, Na+, Ca2+, HCO3−and fluoride with strong loading, which pointed out geogenic source of fluoride contamination. Therefore, it was inferred that the groundwater of the contaminated areas must be treated and made potable before consumption. The outcomes of the present study will be helpful for the regulatory boards and policymaker for defining the actual impact and remediation goal.
Computer programmers show distinct, expertise-dependent brain responses to violations in form and meaning when reading code
Authors: Kuo Chu-Hsuan , Prat Chantel S. 
Published: March 2024

AbstractAs computer programming becomes more central to the workforce, the need for better models of how it is effectively learned has become more apparent. The current study addressed this gap by recording electrophysiological brain responses as 62 Python programmers with varying skill levels read lines of code with manipulations of form (syntax) and meaning (semantics). At the group level, results showed that manipulations of form resulted in P600 effects, with syntactically invalid code generating more positive deflections in the 500–800 ms range than syntactically valid code. Meaning manipulations resulted in N400 effects, with semantically implausible code generating more negative deflections in the 300–500 ms range than semantically plausible code. Greater Python expertise within the group was associated with greater sensitivity to violations in form. These results support the notion that skilled programming, like skilled natural language learning, is associated with the incorporation of rule-based knowledge into online comprehension processes. Conversely, programmers at all skill levels showed neural sensitivity to meaning manipulations, suggesting that reliance on pre-existing semantic relationships facilitates code comprehension across skill levels.
Unlocking the potential of smartphone and ambient sensors for ADL detection
Authors: Stojchevska Marija , De Brouwer Mathias , Courteaux Martijn , Steenwinckel Bram , Van Hoecke Sofie , Ongenae Femke 
Published: March 2024

AbstractThe detection of Activities of Daily Living (ADL) holds significant importance in a range of applications, including elderly care and health monitoring. Our research focuses on the relevance of ADL detection in elderly care, highlighting the importance of accurate and unobtrusive monitoring. In this paper, we present a novel approach that that leverages smartphone data as the primary source for detecting ADLs. Additionally, we investigate the possibilities offered by ambient sensors installed in smart home environments to complement the smartphone data and optimize the ADL detection. Our approach uses a Long Short-Term Memory (LSTM) model. One of the key contributions of our work is defining ADL detection as a multilabeling problem, allowing us to detect different activities that occur simultaneously. This is particularly valuable since in real-world scenarios, individuals can perform multiple activities concurrently, such as cooking while watching TV. We also made use of unlabeled data to further enhance the accuracy of our model. Performance is evaluated on a real-world collected dataset, strengthening reliability of our findings. We also made the dataset openly available for further research and analysis. Results show that utilizing smartphone data alone already yields satisfactory results, above 50% true positive rate and balanced accuracy for all activities, providing a convenient and non-intrusive method for ADL detection. However, by incorporating ambient sensors, as an additional data source, one can improve the balanced accuracy of the ADL detection by 7% and 8% of balanced accuracy and true positive rate respectively, on average.
Intergenerational continuity of loneliness and potential mechanisms: Young Finns Multigenerational Study
Authors: Elovainio Marko , Komulainen Kaisla , Hakulinen Christian , Pahkala Katja , Rovio Suvi , Hutri Nina , Raitakari Olli T. , Pulkki-Råback Laura 
Published: March 2024

AbstractEvidence on the intergenerational continuity of loneliness and on potential mechanisms that connect loneliness across successive generations is limited. We examined the association between loneliness of (G0) parents (859 mothers and 570 fathers, mean age 74 years) and their children (G1) (433 sons and 558 daughters, mean age 47 years) producing 991 parent–offspring pairs and tested whether these associations were mediated through subjective socioeconomic position, temperament characteristics, cognitive performance, and depressive symptoms. Mean loneliness across parents had an independent effect on their adult children’s experienced loneliness (OR = 1.72, 95% CI 1.23–2.42). We also found a robust effect of mothers’ (OR = 1.64, 95% CI 1.17–2.29), but not of fathers’ loneliness (OR = 1.47, 95% CI 0.96–2.25) on offspring’s experienced loneliness in adulthood. The associations were partly mediated by offspring depressive (41–54%) and anxiety (29–31%) symptoms. The current findings emphasize the high interdependence of loneliness within families mediated partly by offspring’s mental health problems.
Lack of telomerase reduces cancer incidence and increases lifespan of zebrafish tp53M214K mutants
Authors: Şerifoğlu Naz , Lopes-Bastos Bruno , Ferreira Miguel Godinho 
Published: March 2024

AbstractTelomerase activity is restricted in humans and telomere attrition occurs in several tissues accompanying natural aging. Critically short telomeres trigger DNA damage responses and activate p53 which leads to apoptosis or replicative senescence. These processes reduce cell proliferation and disrupt tissue homeostasis, thus contributing to systemic aging. Similarly, zebrafish have restricted telomerase expression, and telomeres shorten to critical length during their lifespan. Telomerase-deficient zebrafish (tert −/−) is a premature model of aging that anticipates aging phenotypes due to early telomere shortening. tert −/− zebrafish have impaired cell proliferation, accumulation of DNA damage markers and p53 response. These cellular defects lead to disruption of tissue homeostasis, resulting in premature infertility, gastrointestinal atrophy, sarcopenia and kyphosis. Such consequences contribute to its premature death. Here we reveal a genetic interdependence between tp53 and telomerase function. Mutation of tp53 abrogates premature aging of tert −/− zebrafish, prolonging male fertility and lifespan. However, it does not fully rescue healthspan. tp53mut tert −/− zebrafish retain high levels of inflammation and increased spontaneous cancer incidence. Conversely, loss of telomerase prolongs the lifespan of tp53mut single mutants. Lack of telomerase reduces two-fold the cancer incidence in double mutants and increases lifetime survival. Thus, we observe a reciprocal rescue of tp53mut and tert −/− that ameliorates lifespan but not spontaneous cancer incidence of tp53mut, likely due to higher levels of inflammation.
Brain volume measured by synthetic magnetic resonance imaging in adult moyamoya disease correlates with cerebral blood flow and brain function
Authors: Kikuchi Kazufumi , Togao Osamu , Yamashita Koji , Isoda Takuro , Nishimura Ataru , Arimura Koichi , Nakamizo Akira , Yoshimoto Koji , Ishigami Kousei 
Published: March 2024

AbstractMoyamoya disease (MMD) is characterized by progressive arterial occlusion, causing chronic hemodynamic impairment, which can reduce brain volume. A novel quantitative technique, synthetic magnetic resonance imaging (SyMRI), can evaluate brain volume. This study aimed to investigate whether brain volume measured with SyMRI correlated with cerebral blood flow (CBF) and brain function in adult MMD. In this retrospective study, 18 adult patients with MMD were included. CBF was measured using iodine-123-N-isopropyl-p-iodoamphetamine single photon emission computed tomography. Cerebrovascular reactivity (CVR) to acetazolamide challenge was also evaluated. Brain function was measured using the Wechsler Adult Intelligence Scales (WAIS)-III/IV and the WAIS-R tests. Gray matter (GM), white matter, and myelin-correlated volumes were evaluated in six areas. Resting CBF was positively correlated with GM fractions in the right anterior cerebral arterial and right middle cerebral arterial (MCA) territories. CVR was positively correlated with GM fraction in the right posterior cerebral arterial (PCA) territory. Full-Scale Intelligence Quotient and Verbal Comprehension Index scores were marginally positively correlated with GM fractions in the left PCA territory. Processing Speed Index score was marginally positively correlated with GM fraction in the right MCA territory. The SyMRI-measured territorial GM fraction correlated with CBF and brain function in patients with MMD.
Interface engineering and defect passivation for enhanced hole extraction, ion migration, and optimal charge dynamics in both lead-based and lead-free perovskite solar cells
Authors: Noman Muhammad , Khan Abdul Haseeb Hassan , Jan Shayan Tariq 
Published: March 2024

AbstractThe study elucidates the potential benefits of incorporating a BiI3 interfacial layer into perovskite solar cells (PSCs). Using MAPbI3 and MAGeI3 as active layers, complemented by the robust TiO2 and Spiro-OMeTAD as the charge-transport-layers, we employed the SCAPS-1D simulation tool for our investigations. Remarkably, the introduction of the BiI3 layer at the perovskite-HTL interface significantly enhanced hole extraction and effectively passivated defects. This approach minimized charge recombination and ion migration towards opposite electrodes, thus elevating device performance relative to conventional configurations. The efficiency witnessed a rise from 19.28 to 20.30% for MAPbI3 and from 11.90 to 15.57% for MAGeI3. Additionally, MAGeI3 based PSCs saw an improved fill-factor from 50.36 to 62.85%, and a better Jsc from 13.22 to 14.2 mA/cm2, signifying reduced recombination and improved charge extraction. The FF for MAPbI3 based PSCs saw a minor decline, while the Voc slightly ascended from 1.24 to 1.25 V and Jsc from 20.01 to 21.6 mA/cm2. A thorough evaluation of layer thickness, doping, and temperature further highlighted the critical role of the BiI3 layer for both perovskite variants. Our examination of bandgap alignments in devices with the BiI3 interfacial layer also offers valuable understanding into the mechanisms fueling the observed improvements.
A simple estimation method of grid‐forming inverter inertia based on rate of change of frequency
Authors: Han Gang , Xiong Liangli , You Li , Ling Zaixun , Liu Manjia , Cui Yibo , Zhang Sheng , Fang Zhijian 
Published: March 2024

AbstractInertia is the core index of the estimation of power system frequency stability; a simple estimation method of grid‐forming inverter inertia based on the rate of change of frequency (RoCoF) is proposed in this paper. The method records and fits the active power curve by applying RoCoF to obtain the value of the grid‐forming inverter inertia, and it is simpler and higher accuracy compared to existing methods. In addition, the inertia and damping are analysed to support the system, and the relationship equation between the grid frequency slope change and the output active power is derived. Considering the theoretical analyses and influencing factors, the inertia and damping are obtained by using the method of function fitting. The test steps show the simplicity of the proposed test method. Finally, the effectiveness of the proposed method is verified in MATLAB/Simulation and two 1.575‐MW parallel grid‐forming electrochemical energy storage power plants.
Grain growth and its chemical impact in the first hydrostatic core phase
Authors: Navarro-Almaida D. , Lebreuilly U. , Hennebelle P. , Fuente A. , Commerçon B. , Le Gal R. , Wakelam V. , Gerin M. , Riviére-Marichalar P. , Beitia-Antero L. , Ascasibar Y. 
Published: March 2024

Context. The first hydrostatic core (FHSC) phase is a brief stage in the protostellar evolution that is difficult to detect. Its chemical composition determine that of later evolutionary stages. Numerical simulations are the tool of choice to study these objects.
Aims. Our goal is to characterize the chemical evolution of gas and dust during the formation of the FHSC. Moreover, we are interested in analyzing, for the first time with 3D magnetohydrodynamic (MHD) simulations, the role of grain growth in its chemistry.
Methods. We postprocessed 2 × 105 tracer particles from a RAMSES non-ideal MHD simulation using the codes NAUTILUS and SHARK to follow the chemistry and grain growth throughout the simulation.
Results. Gas-phase abundances of most of the C, O, N, and S reservoirs in the hot corino at the end of the simulation match the ice-phase abundances from the prestellar phase. Interstellar complex organic molecules such as methyl formate, acetaldehyde, and formamide are formed during the warm-up process. Grain size in the hot corino (nH > 1011 cm−3) increases forty-fold during the last 30 kyr, with negligible effects on its chemical composition. At moderate densities (1010 < nH < 1011 cm−3) and cool temperatures 15 < T < 50 K, increasing grain sizes delay molecular depletion. At low densities (nH ~ 107 cm−3), grains do not grow significantly. To assess the need to perform chemo-MHD calculations, we compared our results with a two-step model that reproduces well the abundances of C and O reservoirs, but not the N and S reservoirs.
Conclusions. The chemical composition of the FHSC is heavily determined by that of the parent prestellar core. Chemo-MHD computations are needed for an accurate prediction of the abundances of the main N and S elemental reservoirs. The impact of grain growth in moderately dense areas delaying depletion permits the use of abundance ratios as grain growth proxies.
Cosmic-ray diffusion in two local filamentary clouds
Authors: Kamal Youssef F. R. , Grenier I. A. 
Published: March 2024

Context. Hadronic interactions between cosmic rays (CRs) and interstellar gas have been probed in γ rays across the Galaxy. A fairly uniform CR distribution is observed up to a few hundred parsecs from the Sun, except in the Eridu cloud, which shows an unexplained 30–50% deficit in GeV to TeV CR flux.
Aims. To explore the origin of this deficit, we studied the Reticulum cloud, which shares notable traits with Eridu: a comparable distance in the low-density region of the Local Valley and a filamentary structure of atomic hydrogen extending along a bundle of ordered magnetic-field lines that are steeply inclined to the Galactic plane.
Methods. We measured the γ-ray emissivity per gas nucleon in the Reticulum cloud in the 0.16–63 GeV energy band using 14 years of Fermi-LAT data. We also derived interstellar properties that are important for CR propagation in both the Eridu and Reticulum clouds, at the same parsec scale.
Results. The γ-ray emissivity in the Reticulum cloud is fully consistent with the average spectrum measured in the solar neighbourhood, but this emissivity, and therefore the CR flux, is 1.57 ± 0.09 times larger than in Eridu across the whole energy band. The difference cannot be attributed to uncertainties in gas mass. Nevertheless, we find that the two clouds are similar in many respects: both have magnetic-field strengths of a few micro-Gauss in the plane of the sky; both are in approximate equilibrium between magnetic and thermal pressures; they have similar turbulent velocities and sonic Mach numbers; and both show magnetic-field regularity with a dispersion in orientation lower than 10°–15° over large zones. The gas in Reticulum is colder and denser than in Eridu, but we find similar parallel diffusion coefficients around a few times 1028 cm2 s−1 in both clouds if CRs above 1 GV in rigidity diffuse on resonant, self-excited Alfvén waves that are damped by ion-neutral interactions.
Conclusions. The loss of CRs in Eridu remains unexplained, but these two clouds provide important test cases to further study how magnetic turbulence, line tangling, and ion-neutral damping regulate CR diffusion in the dominant gas phase of the interstellar medium.
Revisiting the rovibrational (de-)excitation of molecular hydrogen by helium
Authors: Jóźwiak Hubert , Thibault Franck , Viel Alexandra , Wcisło Piotr , Lique François 
Published: March 2024

Context. The collisional (de-)excitation of H2 by He plays an important role in the thermal balance and chemistry of various astro-physical environments, making accurate rate coefficients essential for interpreting observations of the interstellar medium.
Aims. Our goal is to utilize a state-of-the-art potential energy surface (PES) to provide comprehensive state-to-state rate coefficients for He-induced transitions among rovibrational levels of H2.
Methods. We performed quantum scattering calculations for the H2-He system. Thus, we were able to provide state-to-state rate coefficients for 1059 transitions between rovibrational levels of H2, with internal energies up to ≃15 000 cm−1, for temperatures ranging from 20 to 8000 K.
Results. Our results demonstrate a good agreement with previous calculations for pure rotational transitions between low-lying rotational levels. However, we do find significant discrepancies for rovibrational processes involving highly-excited rotational and vibrational states. We attribute these differences to two key factors: (1) the broader range of intramolecular distances covered by ab initio points and (2) the superior accuracy of the PES, resulting from the utilization of the state-of-the-art quantum chemistry methods, compared to previous lower-level calculations.
Conclusions. Radiative transfer calculations performed with the new collisional data indicate that the population of rotational levels in excited vibrational states experiences significant modifications, highlighting the critical need for this updated dataset in models of high-temperature astrophysical environments.
The Relationship between VDR Gene Polymorphisms Bsm1 and Apa1 with Breast Cancer Risk
Authors: Mozaffarizadeh Hengameh , Mokarian Fariborz , Salehi Mansoor , Hakimian Seyyed Mohammad Reza , Moazam Elham , Amoozadehsamakoosh Amirmohammad , Hosseinzadeh Majid , Behnam Mahdieh , Behjati Mohaddeseh , Naseri Alma , Lotfi Marzieh , Tohidi Fatemeh 
Published: March 2024

Abstract
Background In addition to its multifaceted physiological functions, vitamin D is recognized for its protective role against cancer. To manifest its effects, vitamin D engages with the vitamin D receptor (VDR) gene responsible for its encoding. Investigations have unveiled that polymorphisms within the VDR gene exert influence over the expression and/or functionality of the VDR protein. Notably, certain VDR gene polymorphisms have emerged as particularly pertinent in the context of tumorigenesis, including Fok1 (rs2228570), Bsm1 (rs1544410), Taq1 (rs771236), and Apa1 (rs7975232). This study aims to scrutinize the correlation between the Bsm1 and Apa1 polymorphisms and the susceptibility to breast cancer development.
Materials and Methods In this study, 50 patients suffering from breast cancer with less than 6 months breast cancer diagnosis and 50 healthy control individuals have been chosen. Restriction fragment length polymorphism polymerase chain reaction was used to determine the genotype of polymorphisms.
Results The results of the statistical analysis showed that among the studied polymorphisms, there was no correlation with the development of breast cancer.
Conclusion Studies on various cancers have produced inconsistent results regarding vitamin D's role in the development and progression of cancer. Therefore, further research is necessary to determine vitamin D's role in cancer development and progression.
Proposal of a screening instrument for autism spectrum disorder in children (Mini-TEA Scale)
Authors: Forcelini Cassiano Mateus , Ampese Regina , Melo Helena Younes de , Pasin Camila Pereira Neubauer , Pádua José Renato Donadussi , Spanholo Camila Boschetti , Hoffmann Francine Ehrhardt , Diniz Júlia Breitenbach , Capponi Laís Cristine Zanella , Souza Luiza , Zortea Maxciel 
Published: March 2024

Abstract
Background Autism spectrum disorder (ASD) requires trained professionals for its adequate diagnosis. There is a shortage of such professionals in Brazil. Screening tools could identify priority cases. The only instrument for that in Brazilian Portuguese is employed for toddlers up to 2.5 years old.
Objective The Mini-TEA scale was conceived and tested as a screening for children from 2.5 to 12 years old.
Methods After local ethics committee's approval, this study was conducted from December 2022 to April 2023 in the Associação de Pais e Amigos dos Excepcionais, Passo Fundo/RS, of invitations to children's parents/relatives who were under evaluation for ASD and by local advertisement. Inclusion criteria were age from 2.5 to 12 years old; consent from the child's legal guardians. 75 children's parents/relatives were interviewed using the 15-item Mini-TEA scale. After that, children were evaluated for the diagnosis of ASD by a pediatric neurologist. Sensibility and specificity for ASD diagnosis along the Mini-TEA scores were measured. Experts and target population evaluated the validity/reliability of the Mini-TEA scale. The reproducibility of the scores was assessed about 40 days later.
Results From the 75 participants, 28 received a diagnosis of ASD. Scores ≥ 10 on the Mini-TEA scale require further evaluation of the children (sensitivity 100%; specificity 68%). Content validity coefficient (CVC) rendered values > 0.80 (acceptable). Test-retest analyzes with the intraclass correlation coefficient (ICC) indicated excellent reliability (> 0.90). The time spent for applying the screening was about 10 minutes.
Conclusion The Mini-TEA scale presents as an easy tool for screening ASD among children.