bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of vitamin D metabolic activity-related biological effects and corresponding therapeutic targets in prostate cancer
Authors: Ding Lei , Wang Yong , Tang Zhentao , Ni Chenbo , Zhang Qian , Zhai Qidi , Liang Chao , Li Jie 
Published: April 2024

Abstract
Background
Previous studies have unequivocally demonstrated that the vitamin D (VD) metabolism pathway significantly influences prognosis and sensitivity to hormone therapy in prostate cancer (PCa). However, the precise underlying mechanism remains unclear.

Methods
We performed molecular profiling of 1045 PCa patients, leveraging genes linked to VD synthesis and VD receptors. We then identified highly variable gene modules with substantial associations with patient stratification. Subsequently, we intersected these modules with differentially expressed genes between PCa and adjacent paracancerous tissues. Following a meticulous process involving single-factor regression and LASSO regression to eliminate extraneous variables and construct a prognostic model. Within the high-risk subgroup defined by the calculated risk score, we analyzed their differences in cell infiltration, immune status, mutation landscape, and drug sensitivity. Finally, we selected Apolipoprotein E (APOE), which featured prominently in this model for further experimental exploration to evaluate its potential as a therapeutic target.

Results
The prognostic model established in this study had commendable predictive efficacy. We observed diminished infiltration of various T-cell subtypes and reduced expression of co-stimulatory signals from antigen-presenting cells. Mutation analysis revealed that the high-risk cohort harbored a higher frequency of mutations in the TP53 and FOXA genes. Notably, drug sensitivity analysis suggested the heightened responsiveness of high-risk patients to molecular inhibitors targeting the Bcl-2 and MAPK pathways. Finally, our investigation also confirmed that APOE upregulates the proliferative and invasive capacity of PCa cells and concurrently enhances resistance to androgen receptor antagonist therapy.

Conclusion
This comprehensive study elucidated the potential mechanisms through which this metabolic pathway orchestrates the biological behavior of PCa and findings hold promise in advancing the development of combination therapies in PCa.
Combination of electrophysiological mapping, radiofrequency catheter ablation, and atrial appendectomy in a 5-year-old girl with tachycardia-induced cardiomyopathy: a case report
Authors: Zhang Min , Cao Xiaoxiao , Zhang Yong 
Published: April 2024

Abstract
Background
Atrial tachycardia (AT) originating from the left atrial appendage (LAA) is uncommon and the most difficult arrhythmia to eliminate. Therefore, we present the case of a 5-year-old girl with tachycardia-induced cardiomyopathy (TIC) caused by AT originating from the LAA and successfully treated with RFCA associated to left atrial appendectomy. With resolution of AT, we observed a progressive improvement of LV function. The effectiveness and safety of this combination therapy were evaluated over a one-month follow-up period.

Case presentation
A 5 -year-old female was evaluated for three days of incessant cough and a syncopal episode. Surface echocardiography and 24-hour monitoring showed that the infant had persistent atrial tachycardia. Echocardiography revealed an enlarged tele diastolic diameter (46.1 mm) and malfunctioning (EF 28.53%) left ventricle. The location of the lesion at the apex of the LAA was further confirmed by electrophysiological study and RFCA. After RFCA, the infant’s ECG monitor showed that sinus rhythm was maintained for up to 22 h. Subsequently, atrial tachycardia recurred and sinus rhythm disappeared. Finally, atrial appendectomy was performed and sinus rhythm returned to normal.

Conclusions
The heart function of the infant improved and sinus rhythm was maintained, further demonstrating the safety and effectiveness of combined treatment with RFCA and atrial appendectomy after electrophysiological localization of AT from LAA to TIC.
DNA methylation remodeling and the functional implication during male gametogenesis in rice
Authors: Li Xue , Zhu Bo , Lu Yue , Zhao Feng , Liu Qian , Wang Jiahao , Ye Miaomiao , Chen Siyuan , Nie Junwei , Xiong Lizhong , Zhao Yu , Wu Changyin , Zhou Dao-Xiu 
Published: April 2024

Abstract
Background
Epigenetic marks are reprogrammed during sexual reproduction. In flowering plants, DNA methylation is only partially remodeled in the gametes and the zygote. However, the timing and functional significance of the remodeling during plant gametogenesis remain obscure.

Results
Here we show that DNA methylation remodeling starts after male meiosis in rice, with non-CG methylation, particularly at CHG sites, being first enhanced in the microspore and subsequently decreased in sperm. Functional analysis of rice CHG methyltransferase genes CMT3a and CMT3b indicates that CMT3a functions as the major CHG methyltransferase in rice meiocyte, while CMT3b is responsible for the increase of CHG methylation in microspore. The function of the two histone demethylases JMJ706 and JMJ707 that remove H3K9me2 may contribute to the decreased CHG methylation in sperm. During male gametogenesis CMT3a mainly silences TE and TE-related genes while CMT3b is required for repression of genes encoding factors involved in transcriptional and translational activities. In addition, CMT3b functions to repress zygotic gene expression in egg and participates in establishing the zygotic epigenome upon fertilization.

Conclusion
Collectively, the results indicate that DNA methylation is dynamically remodeled during male gametogenesis, distinguish the function of CMT3a and CMT3b in sex cells, and underpin the functional significance of DNA methylation remodeling during rice reproduction.
Some m-fold symmetric bi-univalent function classes and their associated Taylor-Maclaurin coefficient bounds
Authors: Srivastava Hari Mohan , Sabir Pishtiwan Othman , Eker Sevtap Sümer , Wanas Abbas Kareem , Mohammed Pshtiwan Othman , Chorfi Nejmeddine , Baleanu Dumitru 
Published: April 2024

AbstractThe Ruscheweyh derivative operator is used in this paper to introduce and investigate interesting general subclasses of the function class$\Sigma_{m}$Σmofm-fold symmetric bi-univalent analytic functions. Estimates of the initial Taylor-Maclaurin coefficients$\vert a_{m+1} \vert $|am+1|and$\vert a_{2 m+1} \vert $|a2m+1|are obtained for functions of the subclasses introduced in this study, and the consequences of the results are discussed. Additionally, the Fekete-Szegö inequalities for these classes are investigated. The results presented could generalize and improve some recent and earlier works. In some cases, our estimates are better than the existing coefficient bounds. Furthermore, within the engineering domain, the utilization of the Ruscheweyh derivative operator can encompass a broad spectrum of engineering applications, including the robotic manipulation control, optimizing optical systems, antenna array signal processing, image compression, and control system filter design. It emphasizes the potential for innovative solutions that can significantly enhance the reliability and effectiveness of engineering applications.
A surface area formula for compact hypersurfaces in $\mathbb{R}^{n}$
Authors: Huang Yen-Chang 
Published: April 2024

AbstractThe classical Cauchy surface area formula states that the surface area of the boundary $\partial K=\Sigma $
∂
K
=
Σ
of any n-dimensional convex body in the n-dimensional Euclidean space $\mathbb{R}^{n}$

R
n

can be obtained by the average of the projected areas of Σ along all directions in $\mathbb{S}^{n-1}$

S

n
−
1

. In this note, we generalize the formula to the boundary of arbitrary n-dimensional submanifold in $\mathbb{R}^{n}$

R
n

by introducing a natural notion of projected areas along any direction in $\mathbb{S}^{n-1}$

S

n
−
1

. This surface area formula derived from the new notion coincides with not only the result of the Crofton formula but also with that of De Jong (Math. Semesterber. 60(1):81–83, 2013) by using a tubular neighborhood. We also define the projected r-volumes of Σ onto any r-dimensional subspaces and obtain a recursive formula for mean projected r-volumes of Σ.
Asymptotic behaviour and boundedness of solutions for third-order stochastic differential equation with multi-delay
Authors: Mahmoud A. M. , Eisa D. A. , Taie R. O. A. , Bakhit D. A. M. 
Published: April 2024

AbstractIn the present paper, we study stochastic stability and stochastic boundedness for the stochastic differential equation (SDE) with multi-delay of third order. The derived results extend and improve some earlier results in the relevant literature, which are related to the qualitative properties of solutions to third-order delay differential equations (DDEs) and SDEs with multi-delay. Two examples are given to illustrate the results.
IoT workload offloading efficient intelligent transport system in federated ACNN integrated cooperated edge-cloud networks
Authors: Lakhan Abdullah , Grønli Tor-Morten , Bellavista Paolo , Memon Sajida , Alharby Maher , Thinnukool Orawit 
Published: April 2024

AbstractIntelligent transport systems (ITS) provide various cooperative edge cloud services for roadside vehicular applications. These applications offer additional diversity, including ticket validation across transport modes and vehicle and object detection to prevent road collisions. Offloading among cooperative edge and cloud networks plays a key role when these resources constrain devices (e.g., vehicles and mobile) to offload their workloads for execution. ITS used different machine learning and deep learning methods for decision automation. However, the self-autonomous decision-making processes of these techniques require significantly more time and higher accuracy for the aforementioned applications on the road-unit side. Thus, this paper presents the new offloading ITS for IoT vehicles in cooperative edge cloud networks. We present the augmented convolutional neural network (ACNN) that trains the workloads on different edge nodes. The ACNN allows users and machine learning methods to work together, making decisions for offloading and scheduling workload execution. This paper presents an augmented federated learning scheduling scheme (AFLSS). An algorithmic method called AFLSS comprises different sub-schemes that work together in the ITS paradigm for IoT applications in transportation. These sub-schemes include ACNN, offloading, scheduling, and security. Simulation results demonstrate that, in terms of accuracy and total time for the considered problem, the AFLSS outperforms all existing methods.
Spatial and temporal patterns of fuelwood consumption and its associated CO2 emissions in Muzaffarabad division, a western Himalayan region
Authors: Khan Raja Waqar Ahmed , Nazir Nimra , Mehmood Ansar , Qayyum Seema , Shaheen Hamayun 
Published: April 2024

Abstract
Background
In the Himalayan region, fuelwood serves as a critical energy source for rural communities. Being vital for meeting energy needs, fuelwood combustion is a source of carbon dioxide (CO2) emission and, consequently, global warming, as well as deforestation and public health damage. Therefore, quantifying fuelwood consumption patterns and its associated CO2 emissions is essential to understand the environmental impact and promote sustainable resource management.

Methods
This research conducts an evaluation of fuelwood burning patterns and the associated CO2 emissions in Azad Jammu and Kashmir (AJK), situated within the western Himalayan region. The study entails an extensive survey of 24 villages representing 240 households, equally distributed between the subtropical and temperate regions, each comprising 120 households. Data collection was executed through a combination of direct queries and the weight survey method, following standard protocols.

Results
In the study area, the mean annual fuelwood comsumption per household amounts to 24.28 ± 3.1 Mg (or 3.195 ± 1 Mg capita−1). A variance was observed between subtropical and temperate zones, with the latter exhibiting higher consumption rates. The consequential CO2 emissions were assessed as 41.88 ± 4.5 Mg per household (5.51 ± 0.6 Mg capita−1). On a daily basis, households consumed an average of 66.52 ± 6.4 kg of fuelwood (8.75 ± 1.5 kg capita−1), resulting in a daily CO2 release rate of 114.745 ± 8.6 kg (15.095 ± 2 kg capita−1). The findings unveiled seasonal variations, indicating increased fuelwood consumption and emissions during the winter season. Statistical analysis shed light on the significance of altitude and family size in shaping the patterns of fuelwood use.

Conclusions
The results revealed the importance of prioritizing forest conservation and strategically implementing sustainable practices, including reforestation, afforestation, responsible harvesting, and actively promoting sustainable fuel sources. This research highlights the vital role of well-designed policies focused on preserving ecosystems and improving energy management. Policy intervention can ensure the sustainable stewardship of local and regional forest resources.
Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma
Authors: Yalcin Fatih , Haneke Hannah , Efe Ibrahim E. , Kuhrt Leonard D. , Motta Edyta , Nickl Bernadette , Flüh Charlotte , Synowitz Michael , Dzaye Omar , Bader Michael , Kettenmann Helmut 
Published: April 2024

AbstractTumor-associated microglia and blood-derived macrophages (TAMs) play a central role in modulating the immune suppressive microenvironment in glioma. Here, we show that GPNMB is predominantly expressed by TAMs in human glioblastoma multiforme and the murine RCAS-PDGFb high grade glioma model. Loss of GPNMB in the in vivo tumor microenvironment results in significantly smaller tumor volumes and generates a pro-inflammatory innate and adaptive immune cell microenvironment. The impact of host-derived GPNMB on tumor growth was confirmed in two distinct murine glioma cell lines in organotypic brain slices from GPNMB-KO and control mice. Using published data bases of human glioma, the elevated levels in TAMs could be confirmed and the GPNMB expression correlated with a poorer survival.
Bubble-like lucency in pulmonary ground glass nodules on computed tomography: a specific pattern of air-containing space for diagnosing neoplastic lesions
Authors: Liu Si-zhu , Yang Shi-hai , Ye Min , Fu Bin-jie , Lv Fa-jin , Chu Zhi-gang 
Published: April 2024

Abstract
Purpose
To investigate the computed tomography (CT) characteristics of air-containing space and its specific patterns in neoplastic and non-neoplastic ground glass nodules (GGNs) for clarifying their significance in differential diagnosis.

Materials and methods
From January 2015 to October 2022, 1328 patients with 1,350 neoplastic GGNs and 462 patients with 465 non-neoplastic GGNs were retrospectively enrolled. Their clinical and CT data were analyzed and compared with emphasis on revealing the differences of air-containing space and its specific patterns (air bronchogram and bubble-like lucency [BLL]) between neoplastic and non-neoplastic GGNs and their significance in differentiating them.

Results
Compared with patients with non-neoplastic GGNs, female was more common (P < 0.001) and lesions were larger (P < 0.001) in those with neoplastic ones. Air bronchogram (30.1% vs. 17.2%), and BLL (13.0% vs. 2.6%) were all more frequent in neoplastic GGNs than in non-neoplastic ones (each P < 0.001), and the BLL had the highest specificity (93.6%) in differentiation. Among neoplastic GGNs, the BLL was more frequently detected in the larger (14.9 ± 6.0 mm vs. 11.4 ± 4.9 mm, P < 0.001) and part-solid (15.3% vs. 10.7%, P = 0.011) ones, and its incidence significantly increased along with the invasiveness (9.5–18.0%, P = 0.001), whereas no significant correlation was observed between the occurrence of BLL and lesion size, attenuation, or invasiveness.

Conclusion
The air containing space and its specific patterns are of great value in differentiating GGNs, while BLL is a more specific and independent sign of neoplasms.
Reduction of greenhouse gas emissions by optimizing the textile dyeing process using digital twin technology
Authors: Kim Minsuk , Shim Jae Yun , Lim Seungju , Lee Heedong , Kwon Soon Chul , Hong Seokil , Ryu Sujin 
Published: April 2024

AbstractOwing to global warming and pollution concerns, reducing the environmental footprint of the textile and fashion industry has received considerable attention. Within this industry, the dyeing and finishing processes contribute significantly to greenhouse gas emissions and water pollution. This study introduces an innovative approach to address these challenges by leveraging digital twin technology to optimize the textile dyeing process. A smart analysis module was developed to continuously monitor and analyze the dyeing parameters in real time to implement control actions to automatically reduce the process duration. Integrated with this module, a digital twin of the dyeing machine enabled the real-time monitoring of energy consumption and process parameters. A case study comparing the traditional dyeing process with the optimized process was conducted. The results showed that dyeing time was reduced by ~ 17.5% without compromising dyeing quality. Energy consumption and greenhouse gas emissions were also reduced by ~ 12.1% when using the optimized process. This study offers a practical and sustainable option for textile dyeing, particularly for small and medium-sized enterprises.
Baby-friendly workplace initiatives in child feeding practice as predictors of infant and young child anthropometric indices in public health facilities of Southern Ethiopia
Authors: Hasen Habtamu , Kusheta Samuel , Abuhay Efrata , Tumiso Hamdela , Leuel Yenatfanta , Daniel Dinku , Amare Mesganew , Samuel Abraham , Habtu Yitagesu 
Published: April 2024

Abstract
Background
Baby-friendly workplace is an effective evidence based initiative developed by the World Health Organization to protect and support maternal knowledge, beliefs, and confidence in infant and young child feeding practices. However, studies that show the effect of the baby-friendly workplace initiative on the nutritional status of infant and young children are not available in Ethiopia. Therefore, this study aimed to assess the nutritional status among baby friendly initiatives service utlizers and non utlizers children age 6–24 months in public health facilities of Southern Ethiopia.

Methods
We conducted a comparative cross-sectional study from 1 to 30 June 2022 among 220 mothers with children aged 6–24 months. Data were collected through face-to-face interviews using a structured questionnaire. Data were entered into Epidata Software version 4.2 and then exported to IBM SPSS version 26 software for analysis. Chi-square and Fisher exact test were used to assess the differences between users and non-users of the baby friendly workplace initiative. Logistic regression model was used to determine the association between dependent and independent variables. Adjusted odds ratio (AOR) with a 95% confidence interval was computed. P-values < 0.05 at a 95% confidence level were considered statistically significant.

Result
The mean (SD) scores of weight for age (WAZ), height for age (HAZ), and weight for height (WHZ) were − 0.38 (1.34),-0.17(2.62) and-0.35 (1.84) respectively. After adjusting for covariates, children aged 6–24 months who did not use baby friendly workplace initiatives were 2.26 times more likely to have stunting compared to the users of baby friendly workplace initiative (AOR 2.26, 95% CI: 1.05, 4.88). However, both wasting (AOR: 0.42; 95% CI:0.13, 1.37) and underweight (AOR: 1.09; 95% CI: 0.45, 2.60) were not significantly associated with the use of baby friendly workplace initiatives.

Conclusion
The use of baby friendly work place initiatives was successful in improving nutritional status, specifically chronic malnutrition in children. Strengthening and scaling up the baby friendly work place initiative program has the potential to reduce chronic malnutrition in Ethiopia and other similar settings with high burden of malnutrition areas, by implementing it in public facilities.
Association of healthy eating index (2015) with depression and anxiety symptoms among Iranian adolescent girls
Authors: Ghanbarzadeh Elham , Dorosty Motlagh Ahmad Reza , Abbasi Behnood 
Published: April 2024

AbstractAdolescence is a period of rapid growth, with changes in body composition and cognitive and psychosocial development. Teenagers who eat properly and participate in daily physical activities have a healthy lifestyle. Healthy living promotes optimal growth and performance at school and in the workplace and minimizes the risk of chronic nutrient-related diseases. Therefore, the present study was conducted to determine the relationship between the healthy eating index (2015) (HEI-2015) and depression and anxiety among Iranian adolescent girls. This cross-sectional study was designed based on the updated version of HEI-2015. The study population consisted of 412 high school girls aged 12–17 years old. Data were collected about the diet, sociodemographic, and anthropometric characteristics of the participants. HEI and anthropometric characteristics of the participants were measured. The depression, anxiety, and stress scale 42 (DASS-42) questionnaire was used to detect adolescents suffering from depression and anxiety. The relationships of the HEI and anthropometric measures with depression and anxiety were also assessed. The results showed that the HEI is inversely correlated with depression and anxiety in Iranian adolescent girls. HEI was greater in the healthy participants than in those suffering from depression and anxiety (P < 0.0001).