bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized study with mitomycin C + 5‐fluorouracil + cytosine arabinoside (MFC) + 5‐fluorouracil, MFC + tegafur and uracil (UFT), and MF + UFT in advanced gastric cancer: Interinstitutional differences in a multicenter study in Japan
Authors: Furukawa Hiroshi , Iwanaga Takeshi , Nakajima Toshifusa , Okabayashi Kenzo , Nakazato Hiroaki , Hiratsuka Masahiro , Ohta Keiichiro , Kito Tsuyoshi , Yamamura Yoshitaka , Goto Shoji 
Published: February 2007

AbstractIn a phase III randomized trial of adjuvant chemotherapy for gastric cancer, interinstitutional differences were analyzed. A trial of three regimens: mitomycin C, 5‐fluorouracil(5‐FU) and CA (MFC) + continuous oral 5‐FU (Group C); MFC + continuous oral UFT(tegafur and uracil) (Group B); and MF + UFT (Group C) after operation was conducted in 466 patients with gastric cancer (stage II and III) at four hospitals in Japan (CIH, CAD, ACC and NCC). Patients were stratified by the institution, stage, and tumor size (8 cm ><). The 5‐year survival rates were in the order of Group A (79.0%) > B (70.0%) > C (61.0%) (P = 0.1228) in total, A (95.0%) > B (80.0%) > C (58.0%) (P < 0.05) at CAD (82 patients), A > C> B at CIH (215), C> A > B at ACC (95), and B > A > C at NCC (78). The survival rate of patients with S2(serosal exposure), 8 cm < and NO‐1 cancer was higher at CIH than at the other institutions. The interinstitutional differences in patient characteristics and surgical technique were more powerful than the differences among the three groups. © 1995 Wiley‐Liss, Inc.
Optimal management of malignant mesothelioma after subtotal pleurectomy: Revisiting the role of intrapleural chemotherapy and postoperative radiation
Authors: Sauter Edward R. , Langer Corey , Coia Lawrence R. , Goldberg Melvyn , Keller Steven M. 
Published: February 2007

AbstractMalignant pleural mesothelioma (MPM) is a generally fatal disease with no standard treatment. There are encouraging reports using intraperitoneal chemotherapy to treat peritoneal mesotheliomas and intrapleural chemotherapy (IPC) to treat malignant pleural effusions. Our objective was to evaluate the efficacy of IPC after subtotal pleurectomy. Between 1988 and 1992, 20 consecutive patients with diffuse MPM limited to one hemithorax underwent subtotal pleurectomy. Thirteen patients with biopsy‐proven MPM known prior to thoracotomy were enrolled in a phase II combined modality protocol consisting of perioperative intrapleural cisplatin (100 mg/m2) and ara‐C (1,200 mg) after subtotal pleurectomy, followed by systemic cisplatin (50 mg/m2/week × 8) and mitomycin‐C (8 mg/m2, days 1 and 36). Seven patients with MPM could not be enrolled because their diagnosis was made post‐thoracotomy. These patients underwent subtotal pleurectomy with (n = 4) or without (n = 3) adjuvant radiation (4,500–5,000 cGy in 3 patients, 2,100 cGy in 1 patient). One of three patients who developed chemotherapy‐related nephrotoxicity died, the only treatment‐related mortality. All 3 patients requiring postoperative readmission received IPC. Significant morbidity did not occur in patients not receiving chemotherapy. Median survival and time to progression were significantly longer in patients not receiving IPC (21 vs. 9 months, P = 0.04; 12 vs. 6 months, P = 0.01). In conclusion, intrapleural and postoperative systemic chemotherapy resulted in significant toxicity and did not improve survival in our patients who underwent subtotal pleurectomy for MPM. © 1995 Wiley‐Liss, Inc.
Prognosis of breast cancer: Evidence for interaction between c‐erbB‐2 overexpression and number of involved axillary lymph nodes
Authors: Mittra Indraneel , Redkar Alka A. , Badwe Rajan A. 
Published: February 2007

AbstractThe prognostic significance of c‐erbB‐2 oncogene amplification or overexpression in relation to axillary lymph node metastasis is controversial. We investigated this question in 159 cases of operable breast cancer: 56 patients with node negative disease and 103 patients with pathological involvement of axillary lymph nodes. c‐erbB‐2 overexpression was assessed by immunohistochemistry using a polyclonal antibody raised against a synthetic peptide fragment of the oncoprotein. The overall incidence of c‐erbB‐2 overexpression was 35%. c‐erbB‐2 overexpression was significantly related to survival when all patients were considered (P =0.0124), and also for patients with positive axillary lymph nodes (P= 0.0026). c‐erbB‐2 overexpression had no influence on survival of node negative patients (P =0.7972). A multivariate survival analysis using the Cox proportional hazard model revealed thatnumberof involved lymph nodes, c‐erbB‐2 overexpression, ER status, and tumour size were independently related to prognosis (P =0.0000, 0.0012, 0.0112, and 0.0204, respectively). When an interaction term was introduced in the Cox model between c‐erbB‐2 overexpression and number of involved axillary lymph nodes, a statistically highly significant interaction between these two factors was observed (P = 0.0002), suggesting that the expression of prognostic power of c‐erbB‐2 overactivity is related to the number of involved axillary lymph nodes. The 159 patients were then subdivided into three groups: node negative (‐ve) (56); 1–6 node positive ( + ve) (55); and ≥7 node +ve (48). This cutoff criterion gave the most numerically equitable distribution of the 159 patients into three groups. The relative risk of death increased stepwise from 0.86 (95% CI 0.26–2.78) for node negative patients, to 1.95 (95% CJ 0.82–63) for 1–6 node positive patients, to 2.23 (95% Cl 1.15–4.35) for >7 node positive patients. Our results suggest that the prognostic influence of c‐erbB‐2 overexpression increases arithmatically with increasing number of involved axillary lymph nodes. © 1995 Wiley‐Liss, Inc.
Hepatic artery chemoembolization or embolization for primary and metastatic liver tumors: Post‐treatment management and complications
Authors: Berger David H. , Humberto Carrasco C. , Hohn David C. , Curley Steven A. 
Published: February 2007

AbstractThis paper describes complications and patient management issues associated with hepatic arterial chemoembolization (HACE) and embolization (HAE) used to treat liver malignancies and characterizes patient survival based on histologic tumor type. We performed a retrospective review of all patients treated with HACE or HAE between January 1, 1988 and December 31, 1990. During the study period, 314 HACEs and HAEs were performed in 121 patients. Ninety‐six of the patients (79%) were treated for neoplasms metastatic to the liver. The morbidity rate following HACE and HAE in this study was 5.1%. The major complications included portal vein thrombosis, hepatic abscess, and liver failure. The treatment‐related mortality rate was 4.1%. Fever and ileus were the most common management problems following HACE or HAE. Median survival for patients with liver metastases varied according to histologic type, and median survival for patients with hepatocellular cancer was 306 days. Morbidity and mortality from HACE and HAE to treat liver tumors can be minimized by proper selection and careful management of patients. HACE or HAE alone was not curative in any of these 121 patients. An understanding of treatment‐related side effects is necessary to aid in the management of patients following HACE or HAE. © 1995 Wiley‐Liss, Inc.
Follow‐up of patients resected for gastric cancer
Authors: Javier Lacueva F. , Calpena Rafael , Medrano Justo , Compañ Antonio F. , Andrada Encarnación , Moltó Mario , Ferrer Rafael , Diego Manuel 
Published: February 2007

AbstractIn this study we used a cost‐outcome analysis to evaluate our follow‐up protocol for patients who had been resected for gastric cancer. We designed a descriptive cross‐sectional trial through consecutive sampling of patients who had undergone resection of gastric carcinoma and were followed in our outpatient department during 1991. Serological (CEA) and or imaging procedures were pathologic at least two months prior to the onset of symptoms in 33% of recurrences. No significant correlation was found between serum CEA levels and CEA tumor tissue staining in patients who recurred. Only 17% of patients who relapsed underwent further treatment (surgery and chemotherapy) with no improvement found in terms of survival. The overall cost per year has been estimated at US$ 6118. Our results show that serological levels of CEA and available imaging techniques for routine follow‐up provide little advantage in diagnosing gastric cancer recurrence over clinical surveillance alone. © 1995 Wiley‐Liss, Inc.
Intraoperative histologic assessment of surgical margins and lymph node metastasis in breast‐conserving surgery
Authors: Noguchi Masakuni , Minami Masahide , Earashi Mitsuharu , Taniya Takao , Miyazaki Itsuo , Mizukami Yuji , Nonomura Akitaka 
Published: February 2007

AbstractThe diagnostic value of intraoperative histologic examination of frozen sections of surgical margins and axillary lymph nodes (AX) was investigated in 95 patients with breast cancer who underwent breast‐conserving surgery. The periphery of the excised breast tissue was peeled like an orange and examined histologically by frozen section. The results were compared with examination by permanent section. Evaluation of surgical margins by frozen section resulted in a diagnostic accuracy of 87%, a sensitivity of 96%, and a specificity of 84%. Enlarged or hardened AXs were sampled from the axillary pad which was derived from a complete AX dissection. Histologic examination using frozen section was performed during surgery. After the operation, the remaining AXs were removed from the axillary pad by hand dissection and histologically examined on permanent section. A diagnostic accuracy of 97%, a sensitivity of 77%, and a specificity of 100% were achieved in the diagnosis of AX involvement on frozen section. It was therefore concluded that intraoperative histologic examination of frozen sections may be useful in the determination of involvement of the surgical margins and the AXs in patients with breast cancer. © 1995 Wiley‐Liss, Inc.
Familial adenomatous polyposis and lung cancer
Authors: Wong Ralph P. , Hwang Wel‐Sek , Field Stephen K. 
Published: February 2007

AbstractA 43‐year‐old man presented with a lung nodule 19 years after undergoing a total colectomy for familial adenomatous polyposis (FAP). There had been no evidence of malignant transformation in the colectomy specimen, and current gastrointestinal investigation did not reveal evidence of tumor. Pathological analysis of the lung nodule demonstrated adenocarcinoma of the lung of the fetal type. This is the first reported case of a lung neoplasm in a patient with FAP. The development of an unusual lung tumor in a patient with FAP, a condition associated with other extracolonic tumors, suggests that there may be an association between the two conditions. © 1995 Wiley‐Liss, Inc.
Adjuvant six cycles of high‐dose adriamycin, cyclophosphamide, methotrexate, 5‐fluorouracil (ACMF) vs. 12 cycles of low‐dose acmf with tamoxifen for premenopausal, node‐positive breast cancer patients: Results of a prospective randomized study
Authors: Fukutomi Takashi , Akashi Sadako , Nanasawa Takeshi , Yamamoto Hiroshi 
Published: February 2007

AbstractA prospective randomized study was conducted to compare the adjuvant efficacy of six cycles of high‐dose ACMF (Adriamycin, ADM; cyclophosphamide, CPA; methotrexate, MTX; 5‐fluorouracil, 5‐FU) with that of 12 cycles of low‐dose ACMF in premenopausal, node‐positive breast cancer patients. The six‐cycle ACMF group (93 patients) received, intravenously (iv), 130 mg/m2CPA, 26 mg/m2MTX, and 600 mg/m25‐FU on days 1 and 8, and 26 mg/m2ADM on day 1 of each cycle. The 12‐cycle ACMF group (97 patients) received, iv, 65 mg/m2CPA, 13 mg/m2MTX, and 300 mg/m25‐FU on days 1 and 8, and 13 mg/m2ADM on day 1 of each cycle. These treatments were repeated every 4 weeks, and all the patients took tamoxifen (30 mg/day) for 2 years. The background factors of the two groups were comparable. There were non‐significant trends toward better disease‐free and overall survival rates in the high‐dose, six‐cycle ACMF group. Both treatments were well tolerated, but more patients in the low‐dose, 12‐cycle group refused to continue to receive chemotherapy. These data suggest that escalating doses of ACMF over a shorter period, even with doses within the conventional range, are superior to low‐dose, prolonged therapy. © 1995 Wiley‐Liss, Inc.
Malignant tumors metastatic to the ovaries
Authors: Ayhan Ali , Sel Tuncer Z. Çuk , Bükülmez Orhan 
Published: February 2007

AbstractOne hundred sixty‐eight patients treated at Hacettepe Hospital between 1969–1993 with metastatic ovarian tumors constituted 21.5% of all malignant ovarian neoplasms. Primary tumors were endometrial (51), breast (27), colorectal (18), and stomach cancer (17), lymphoma (14), sarcoma of the uterus (13), undetermined (11), tumors of the appendix (6) and ileum (4), carcinoma of the cervix (4), and gestational trophoblastic neoplasia (3). Overall 5‐year and median survivals were 20.0% and 26.8 months, respectively. While worse prognoses were seen in gastric cancer and undetermined tumors followed by colorectal cancer, best survival figures were observed in endometrial cancer patients. A trend toward a better survival was seen with the advancement of the operation from bilateral salpingooophorectomy and/or biopsy to total abdominal hysterectomy, bilateral salpingooophorectomy, total omentectomy and pelvic and paraaortic lymphadenectomy with debulking. Multivariate analysis identified the primary site, grade, laterality of involvement, type of surgery and adjuvant therapy status as significant prognostic parameters. Maximal surgical effort followed by adjuvant therapy might at least have short term survival benefit in certain types metastatic to the ovaries. © 1995 Wiley‐Liss, Inc.
Synchronous cancers of the esophagus and the ampulla of vater after distal gastrectomy: Successful removal of the esophagus, gastric remnant, duodenum, and pancreatic head
Authors: Mafune Ken‐ichi , Tanaka Yoichi , Ma Yan‐Yan , Takubo Kaiyo 
Published: February 2007

AbstractA case of synchronous squamous cell carcinoma of the esophagus and adenocarcinoma of the ampulla of Vater after previous gastrectomy is presented. The coexistence of these two lesions has never been reported in the English literature. We performed a subtotal esophagectomy, total residual gastrectomy, and pancreaticoduodenectomy with lymph node dissection in a one‐stage procedure. An operation of this magnitude could be safely performed with attention to meticulous surgical technique and intensive postoperative care.Histologic examination of the ampulla lesion showed adenocarcinoma with Paneth‐cell differentiation. This is a rare lesion, and a review of the literature revealed only one other case. Neoplastic Paneth cells were also found in a lymph node metastasis that originated from the ampulla tumor. This case confirms that cells with Paneth‐cell differentiation can be a significant component in invasive carcinoma. © 1995 Wiley‐Liss, Inc.
Spatial variability and temporal dynamics analysis of soil erosion due to military land use activities: uncertainty and implications for land management
Authors: Wang G. , Gertner G. , Anderson A. B. , Howard H. , Gebhart D. , Althoff D. , Davis T. , Woodford P. 
Published: February 2007

AbstractHuman activities, such as military off‐road vehicular traffic, disturb ground and vegetation cover of landscapes and increase potential rainfall related runoff and soil erosion. On military lands, soil erosion is of major concern in order to sustain training lands and thus there is a need for land condition maps for planning training activities and land management. In this study, we presented a conditional co‐simulation algorithm to generate annual time series maps of soil erosion status from 1989 to 2001 for an army installation. The spatial variability and temporal dynamics of land condition were analyzed. This algorithm modeled soil erosion as realizations of a random function by combining a set of permanent plot data and Landsat Thematic Mapper (TM) images. In addition to estimation maps of soil erosion status, we obtained the maps of uncertainties including the variance of each pixel estimate and the probability of poor land condition. The results and maps are useful tools for land managers and decision‐makers to guide military training programs and to generate management plans for sustaining training lands. Copyright © 2007 John Wiley & Sons, Ltd.
Farmers' perceptions of soil erosion and soil fertility loss in Southern Ethiopia
Authors: Moges Awdenegest , Holden N. M. 
Published: February 2007

AbstractData and information about farmers' perceptions of soil degradation were collected using household survey, focus group discussion and field observations. The results indicate that farmers in the Sidama zone of southern Ethiopia are able to identify soil erosion and fertility loss indicators, take a holistic view of soil degradation and have a broad knowledge of the reasons for soil degradation. They perceive soil degradation mainly by reduced yields, soil changing in appearance and becoming stoney or coarse. The most frequently mentioned soil erosion indicator was soil becoming coarse and stony, followed by rill formation, dissection of fields and gullies and topsoil removal. The most important perceived indicator of soil fertility loss was reduced crop yield, followed by poor crop performance and yellowing of the crop. Farmers also have knowledge of solutions; however, participation in soil conservation activities is minimal because of the immediate threat of food insecurity. Any programme designed to address soil degradation in the region will have to be cognisant of farmers' knowledge and holistic view of soil degradation, and be integrated with aid measures to guarantee food security. Copyright © 2007 John Wiley & Sons, Ltd.
Correlation between collagen solubility and skin optical clearing using sugars
Authors: Hirshburg Jason , Choi Bernard , Nelson J. Stuart , Yeh Alvin T. 
Published: February 2007

AbstractBackground and ObjectiveLight scattering from collagen within skin limits light‐based therapeutics while increasing the risk of epidermal thermal injury. Specific chemicals show the ability to reduce light scattering by reversibly altering the optical properties of skin. This study examines the correlation between collagen solubility and the optical clearing potential (OCP) of sugars and sugar‐alcohols using in vitro rodent skin.Materials and MethodsCollagen solubility in dextrose, fructose, sucrose, and sorbitol was measured using near‐UV spectroscopy. Light transmittance, reflectance, and rodent skin thickness were measured (giving skin reduced scattering coefficient) before and after exposure of the dermal surface to sugars and sugar‐alcohols. OCP was calculated as the ratio of reduced scattering coefficients before and after exposures.ResultsDextrose, fructose, sucrose, and sorbitol had at least twice the collagen solubility and twice the OCP as compared to glycerol. In general, collagen solubility correlated with each agent's ability to optically clear rodent skin.ConclusionThese results demonstrate that sugar and sugar–alcohol interaction with collagen are a primary event in tissue optical clearing. Lasers Surg. Med. 39:140–144, 2007. © 2007 Wiley‐Liss, Inc.
Clinical and echographic analysis of photodynamic therapy using methylaminolevulinate as sensitizer in the treatment of photodamaged facial skin
Authors: Zane Cristina , Capezzera Rossana , Sala Raffaella , Venturini Marina , Calzavara‐Pinton Piergiacomo 
Published: February 2007

AbstractBackground and ObjectivePhotodynamic therapy (PDT) using aminolevulinic acid (ALA) has been previously investigated in the treatment of photodamaged skin. The aim was to assess efficacy and tolerability of methylaminolevulinate (MAL) as a substitute for ALA in PDT treatment of actinic keratosis (AK) and photoaging.Study Design/Materials and MethodsTwenty patients with multiple (n = 137) AKs and severe photodamage of the face were treated. Metvix® (Galderma, France) was applied under occlusion for 3 hours before exposure to 37 J/cm2 of red light (Aklilite® CL 128, Photocure, Norway). Two treatments were given at monthly intervals.ResultsThe clearance rate of AKs was 88.3%, and global score which we use to rate photoaging, mottled hyperpigmentation, fine lines, roughness, and sallowness of the skin showed improvement, but deep wrinkles, teleangiectasia, facial erythema, and sebaceous gland hypertrophy did not change. The treatments were well tolerated. High‐resolution echography showed an increase in skin thickness, pixels count and area, as well as a reduction of the subepidermal low‐echogenic band (SLEB) thickness.ConclusionMAL‐PDT is an effective treatment for multiple AKs. In addition, it improves clinical signs of photodamage of the surrounding skin. Lasers Surg. Med. 39:203–209, 2007. © 2007 Wiley‐Liss, Inc.
CCNU and bleomycin in the treatment of cancer: A southwest oncology group study
Authors: Hoogstraten Barth , Haas Charles D. , Haut Arthur , Talley Robert W. , Rivkin Saul , Isaacs Bertha L. 
Published: February 2007

AbstractCCNU and Bleomycin, alone or in combination, were used to treat 397 evaluable cases of advanced cancer. Responses defined as 50% or greater reduction in all tumor masses occurred in 13/35 lymphomas, 8/50 brain cancers, and 28/312 other solid tumors. Hematologic toxicity of a life‐threatening degree occurred in 33/298 patients evaluable for CCNU toxicity; in an additional 50 it was considered severe. Pulmonary toxicity was severe in 4 patients. Drug‐associated deaths (4) included one each due to leukopenia and thrombocytopenia after CCNU; one due to pulmonary toxicity after Bleomycin; and one due to shock after the 20th dose of Bleomycin. There was no suggestion of synergism or additive activity with the two drugs.
Clinical studies of 5‐fluorouracil + premarin in the treatment of breast cancer
Authors: Taylor Samuel G. , Pocock Stuart J. , Shnider Bruce I. , Colsky Jacob , Hall Thomas C. 
Published: February 2007

AbstractSixty patients with metastatic or primary inoperable breast cancer not suitable for hormone alteration therapy were blindly randomized between weekly 5‐fluorouracil, intravenously, and daily physiologic doses of conjugated estrogens by mouth against weekly 5‐fluorouracil, intravenously, and placebo. There was no difference in the survival or the effect on the tumor in the two groups. Numerous factors were analyzed as to their effect on the course of the disease. The number of organ sites of tumor involvement, age of the host, and previous treatment for the disseminated disease were not shown to influence the survival or the results of therapy of either group. However, the duration of the clinical cancer‐free period from primary treatment to recurrence, the sites of organ involvement, and the performance status of the patients at the time of entry into the study significantly did influence the survival. There is no evidence in this study that physiologic doses of conjugated estrogens deleteriously influenced the course of the disease.
The effect of a lymphotoxic factor from patients with multiple sclerosis on acute lymphosarcoma cell leukemia and acute lymphoblastic leukemia
Authors: Armentrout Steven A. , White Gregory , Van Den Noort Stanley 
Published: February 2007

AbstractEight patients with acute lymphosarcoma cell leukemia or acute lymphoblastic leukemia received infusions of plasma containing a lymphotoxic factor. The lymphotoxic factor induced a transient fall in the number of “blast” cell forms in the peripheral blood in six of the eight patients but did not produce sustained remissions.Previous investigations have demonstrated that this lymphotoxic factor, found in the plasma of patients with active multiple sclerosis, is of low molecular weight and does not have the properties normally associated with an antibody. This factor appears to selectively interfere with ribonucleic acid synthesis in the thymusderived lymphocyte. Lymphotoxic factor activity was demonstrated in the serum of one patient during a remission in leukemia induced by a viral illness.