bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Manganese‐Based Nanodriver Coordinates Tumor Prevention and Suppression through STING Activation in Glioblastoma
Authors: Zhang Wenyuan , Lu Liejing , Zhu Zheng , Deng Fuan , Zhang Wenchang , Wang Fengyi , Zeng Ping , Shi Haonan , Wang Tong , Chen Yichi , Song Yue , Liu Yiping , Kang Tianze , Li Kai , Mao Jie , Liu Zhengwei , Zhang Lu 
Published: April 2024

AbstractGlioblastoma (GBM), the most prevalent and aggressive primary malignant brain tumor, exhibits profound immunosuppression and demonstrates a low response rate to current immunotherapy strategies. Manganese cations (Mn2+) directly activate the cGAS/STING pathway and induce the unique catalytic synthesis of 2′3'‐cGAMP to facilitate type I IFN production, thereby enhancing innate immunity. Here, a telodendrimer and Mn2+‐based nanodriver (PLHM) with a small size is developed, which effectively target lymph nodes through the blood circulation and exhibit tumor‐preventive effects at low doses of Mn2+ (3.7 mg kg−1). On the other hand, the PLHM nanodriver also exhibits apparent antitumor effects in GBM‐bearing mice via inducing in vivo innate immune responses. The combination of PLHM with doxorubicin nanoparticles (PLHM‐DOX NPs) results in superior inhibition of tumor growth in GBM‐bearing mice due to the synergistic potentiation of STING pathway functionality by Mn2+ and the presence of cytoplasmic DNA. These findings demonstrate that PLHM‐DOX NPs effectively stimulate innate immunity, promote dendritic cell maturation, and orchestrate cascaded infiltration of CD8 cytotoxic T lymphocytes within glioblastomas characterized by low immunogenicity. These nanodivers chelated with Mn2+ show promising potential for tumor prevention and antitumor effects on glioblastoma by activating the STING pathway.
Arising 2D Perovskites for Ionizing Radiation Detection
Authors: Li Weijun , Li Mingbian , He Yuhong , Song Jinmei , Guo Keke , Pan Wanting , Wei Haotong 
Published: April 2024

Abstract2D perovskites have greatly improved moisture stability owing to the large organic cations embedded in the inorganic octahedral structure, which also suppresses the ions migration and reduces the dark current. The suppression of ions migration by 2D perovskites effectively suppresses excessive device noise and baseline drift and shows excellent potential in the direct X‐ray detection field. In addition, 2D perovskites have gradually emerged with many unique properties, such as anisotropy, tunable bandgap, high photoluminescence quantum yield, and wide range exciton binding energy, which continuously promote the development of 2D perovskites in ionizing radiation detection. This review aims to systematically summarize the advances and progress of 2D halide perovskite semiconductor and scintillator ionizing radiation detectors, including reported alpha (α) particle, beta (β) particle, neutron, X‐ray, and gamma (γ) ray detection. The unique structural features of 2D perovskites and their advantages in X‐ray detection are discussed. Development directions are also proposed to overcome the limitations of 2D halide perovskite radiation detectors.
Thermally Activated Delayed Fluorescence with Nanosecond Emission Lifetimes and Minor Concentration Quenching: Achieving High‐Performance Nondoped and Doped Blue OLEDs
Authors: Wu Shao‐Jie , Fu Xi‐Feng , Zhang Dong‐Hai , Sun Yu‐Fu , Lu Xin , Lin Fu‐Lin , Meng Lingyi , Chen Xu‐Lin , Lu Can‐Zhong 
Published: April 2024

AbstractSimultaneously achieving a high photoluminescence quantum yield (PLQY), ultrashort exciton lifetime, and suppressed concentration quenching in thermally activated delayed fluorescence (TADF) materials is desirable yet challenging. Here, a novel acceptor–donor–acceptor type TADF emitter, namely, 2BO‐sQA, wherein two oxygen‐bridged triarylboron (BO) acceptors are arranged with cofacial alignment and positioned nearly orthogonal to the rigid dispirofluorene‐quinolinoacridine (sQA) donor is reported. This molecular design enables the compound to achieve highly efficient (PLQYs up to 99%) and short‐lived (nanosecond‐scale) blue TADF with effectively suppressed concentration quenching in films. Consequently, the doped organic light‐emitting diodes (OLEDs) base on 2BO‐sQA achieve exceptional electroluminescence performance across a broad range of doping concentrations, maintaining maximum external quantum efficiencies (EQEs) at over 30% for doping concentrations ranging from 10 to 70 wt%. Remarkably, the nondoped blue OLED achieves a record‐high maximum EQE of 26.6% with a small efficiency roll‐off of 14.0% at 1000 candelas per square meter. By using 2BO‐sQA as the sensitizer for the multiresonance TADF emitter ν‐DABNA, TADF‐sensitized fluorescence OLEDs achieve high‐efficiency deep‐blue emission. These results demonstrate the feasibility of this molecular design in developing TADF emitters with high efficiency, ultrashort exciton lifetime, and minimal concentration quenching.
Toughening Hydrogels with Fibrillar Connected Double Networks
Authors: Fang Yu‐Huang , Liang Chen , Liljeström Ville , Lv Zhong‐Peng , Ikkala Olli , Zhang Hang 
Published: April 2024

AbstractBiological tissues, such as tendons or cartilage, possess high strength and toughness with very low plastic deformations. In contrast, current strategies to prepare tough hydrogels commonly utilize energy dissipation mechanisms based on physical bonds that lead to irreversible large plastic deformations, thus limiting their load‐bearing applications. This article reports a strategy to toughen hydrogels using fibrillar connected double networks (fc‐DN), which consist of two distinct but chemically interconnected polymer networks, that is, a polyacrylamide network and an acrylated agarose fibril network. The fc‐DN design allows efficient stress transfer between the two networks and high fibril alignment during deformation, both contributing to high strength and toughness, while the chemical crosslinking ensures low plastic deformations after undergoing high strains. The mechanical properties of the fc‐DN network can be readily tuned to reach an ultimate tensile strength of 8 MPa and a toughness of above 55 MJ m−3, which is 3 and 3.5 times more than that of fibrillar double network hydrogels without chemical connections, respectively. The application potential of the fc‐DN hydrogel is demonstrated as load‐bearing damping material for a jointed robotic lander. The fc‐DN design provides a new toughening mechanism for hydrogels that can be used for soft robotics or bioelectronic applications.
4D Printing for Biomedical Applications
Authors: Yarali Ebrahim , Mirzaali Mohammad J. , Ghalayaniesfahani Ava , Accardo Angelo , Diaz‐Payno Pedro J. , Zadpoor Amir A. 
Published: April 2024

Abstract4D (bio‐)printing endows 3D printed (bio‐)materials with multiple functionalities and dynamic properties. 4D printed materials have been recently used in biomedical engineering for the design and fabrication of biomedical devices, such as stents, occluders, microneedles, smart 3D‐cell engineered microenvironments, drug delivery systems, wound closures, and implantable medical devices. However, the success of 4D printing relies on the rational design of 4D printed objects, the selection of smart materials, and the availability of appropriate types of external (multi‐)stimuli. Here, this work first highlights the different types of smart materials, external stimuli, and design strategies used in 4D (bio‐)printing. Then, it presents a critical review of the biomedical applications of 4D printing and discusses the future directions of biomedical research in this exciting area, including in vivo tissue regeneration studies, the implementation of multiple materials with reversible shape memory behaviors, the creation of fast shape‐transformation responses, the ability to operate at the microscale, untethered activation and control, and the application of (machine learning‐based) modeling approaches to predict the structure–property and design–shape transformation relationships of 4D (bio)printed constructs.
A Review of Synthesis and Novel Transport Properties of Multivalent Manganate Perovskite: Progress, Opportunities, and Challenges
Authors: Feng Shouhua , Zhang Yaowen , Hou Hongwei , Wen Chunxia , Dong Xuanchen , Shi Wenshu , Lv Ruike , Fu Meichun , Liu Junwei , Lu Jiajun , Duan Longhui , Han Mei , Zheng Beining , Gao Lu 
Published: April 2024

AbstractUnderstanding the microstructure of materials and their impact on performance is crucial for new electronic devices design. The strong interaction between multiple degrees of freedom (spin, orbit, charge, and lattice) within perovskite type oxides can generate rich electron phase diagrams. The microscopic modulation of manganese ions electron states in rare earth manganate perovskites is the root of many novel macroscopic quantum behaviors, such as giant magnetoresistance phenomenon. For ABO3 type perovskites, the differences of radii and valence states of A‐site ions are used to regulate the coexistence of B site manganese multivalent states (Mn3+, Mn4+, Mn5+), and its ordered structure in the metastable state will create a new combination of electronic states. The ordered arrangement of the multi‐dimensional space of electronic states can induce unique transport properties. Therefore, the preparation of manganate perovskites will provide strong chemical support to construct new generation quantum devices. This review summarizes the challenges and difficulties on constructing trivalent coexisting metastable phase in manganate perovskites through disproportionation reactions, and discusses the status and potential of designing ideal rectified p‐n junctions taking advantage of this unique structure. Finally, the foregrounds of new quantum states driven by this chemical reaction are prospected.
Ferroelectric Polarization‐Mediated Modulation of Optical Properties in 2D van der Waals Architectures
Authors: Wan Yi , Liu Mingyan , Li Fang , Qu Ziyang , Zhao Yibin , Peng Yuxuan , Li Pan , Chen Zuxin , Chen Shanbao , Yang Jinbo , Huang Chengxi , Kan Erjun 
Published: April 2024

AbstractThe integration of 2D ferroelectric materials with 2D photoelectric materials presents a promising avenue for addressing issues related to controlled doping and device integration in layered semiconductors. The reversible and non‐volatile residual polarization inherent to ferroelectrics can provide stable n‐ or p‐type doping for 2D semiconductors. Despite advances in doping strategies for 2D materials, existing techniques, and post‐doping characterization methodologies exhibit limitations, including the challenge of achieving high‐resolution graphical depictions of doped structures. Here, a WS2/CuInP2S6 heterostructure is demonstarted whereby the residual polarization of ferroelectric CuInP2S6 regions with anti‐parallel directions supplies screening charges of opposite signs to WS2 monolayers. This notably alters the ratio of neutral excitons and negatively charged trions within the recombination luminescence of the direct‐gap semiconductor, thereby offering a viable approach for controllable, non‐volatile modulation in 2D systems. Beyond proposing a feasible strategy for patterned doping and effective regulation in 2D semiconductors through interface engineering, this work enhances the understanding of the interplay between ferroelectrics and semiconductors.
Accelerated Sulfur Redox Kinetics on Transition Metal Sulfide Electrocatalysts by Modulating Electronic‐State of Active Sites
Authors: Wang Xiaoting , Liu Siyu , Yang Juan , He Songjie , Qiu Jieshan 
Published: April 2024

AbstractLithium‐sulfur (Li‐S) batteries are considered a competitive next‐generation electrochemical energy storage device, while the shuttle effect of soluble lithium polysulfides (LiPSs) resulting from the sluggish redox kinetics severely impedes their practical applications. Herein, a novel cation doping strategy is demonstrated for substantially accelerating the sulfur redox kinetics on the transition metal sulfide (TMS) electrocatalysts by partially substituting cobalt atoms with in situ dissolved Ni dopants (NixCo3‐xS4, 0<x≤1). Theoretical calculations revealed that the doping of Ni in the spinel Co3S4 phase enables the electronic‐state modulation of metal active sites by realizing the upshift of the d‐orbital center, thus leading to good chemical adsorption of intermediates and low redox conversion barriers between LiPSs and solid Li2S products. This is confirmed by in‐depth electrochemical dynamics and in situ Raman characterizations, in which the obtained Ni0.5Co2.5S4 with hierarchical nanosheet structure delivers the stronger chemical affinity of Li2S6 and higher precipitation/dissociation capacity of Li2S in comparison to monometallic cobalt sulfides. Benefiting from these outstanding attributes, the assembled Li‐S batteries by incorporating Ni0.5Co2.5S4 electrocatalysts into S@carbon nanotube cathode (S@Ni0.5Co2.5S4/CNT) exhibit a high specific capacity of 1189 mAh g−1 with excellent rate performance of 596 mAh g−1 at 5 C and long‐term cycling performance over 600 cycles with a capacity decay of 0.06% per cycle at 1 C. More importantly, an ultrahigh reversible areal capacity of 6.6 mAh cm−2 can be achieved for S@Ni0.5Co2.5S4/CNT cathode even with a high sulfur loading of 6.1 mg cm−2. This work demonstrates a new insight into designing TMS electrocatalysts toward rapid redox conversion kinetics in Li‐S batteries.
The drivers of intraspecific trait variation and their implications for future tree productivity and survival
Authors: Blumstein Meghan 
Published: April 2024

AbstractForests are facing unprecedented levels of stress from pest and disease outbreaks, disturbance, fragmentation, development, and a changing climate. These selective agents act to alter forest composition from regional to cellular levels. Thus, a central challenge for understanding how forests will be impacted by future change is how to integrate across scales of biology. Phenotype, or an observable trait, is the product of an individual's genes (G) and the environment in which an organism lives (E). To date, researchers have detailed how environment drives variation in tree phenotypes over long time periods (e.g., long‐term ecological research sites [LTERs]) and across large spatial scales (e.g., flux network). In parallel, researchers have discovered the genes and pathways that govern phenotypes, finding high degrees of genetic control and signatures of local adaptation in many plant traits. However, the research in these two areas remain largely independent of each other, hindering our ability to generate accurate predictions of plant response to environment, an increasingly urgent need given threats to forest systems. I present the importance of both genes and environment in determining tree responses to climate stress. I highlight why the difference between G versus E in driving variation is critical for our understanding of climate responses, then propose means of accelerating research that examines G and E simultaneously by leveraging existing long‐term, large‐scale phenotypic data sets from ecological networks and adding newly affordable sequence (‐omics) data to both drill down to find the genes and alleles influencing phenotypes and scale up to find how patterns of demography and local adaptation may influence future response to change.
Coronary computed tomography–angiography for traumatic coronary artery transection
Authors: Nagashima Kenta , Hayashida Tomohiro , Yamada Eiji , Ishibashi Naoki , Mimura Naoki , Kashitani Nobuhiro 
Published: April 2024

AbstractBackgroundPenetrating thoracic trauma with coronary artery transection is a lethal injury, but is rare. We report a case of a cardiac stab wound with coronary artery transection that was successfully treated after preoperative diagnosis.Case PresentationA 36‐year‐old man was transferred to our emergency department with a left chest stab wound. A coronary computed tomography‐angiography scan, including coronary angiography, revealed left hemopneumothorax and left anterior descending branch transection, with ischemic changes in the left ventricular myocardium. Given the diagnosis of coronary artery transection and the absence of injury to the surrounding arteries, we were able to perform coronary artery bypass surgery using the left internal thoracic artery. The patient's postoperative course was good, and he was discharged on foot without major complications 18 days after surgery.ConclusionUnless a resuscitative thoracotomy is required, a preoperative computed tomography scan, including coronary angiography, may be useful for accurate preoperative diagnosis for patients at high risk of myocardial or coronary artery injury.
Germaaluminocene – Maskierte Heterofulvene
Authors: Geibel Nadeschda , Bührmann Lukas , Albers Lena , Schmidtmann Marc , Weiz Alexander , Müller Thomas 
Published: April 2024

AbstractSalzmetathesereaktionen zwischen Dikaliumgermacyclopentadiendiiden und Pentamethylcyclopentadienylaluminiumdichlorid bieten einen Zugang zu Germaaluminocenen. Das Reaktionsverhalten dieser Sandwichkomplexe wird durch das elektrophile, zentrale Aluminiumatom und das nukleophile, dikoordinierte Germaniumzentrum bestimmt. Überraschenderweise entsprechen die Produkte, welche bei den Reaktionen mit Lewis‐Säuren, Lewis‐Basen, amphiphilen Verbindungen und solchen mit polaren Doppelbindungen entstehen, denen, die bei der Reaktion eines hypothetischen Aluminagermapentafulvens mit derartigen Reaktandentypen erwartet werden. Dies legt nahe, dass es sich bei den Germaaluminocenen um synthetische Äquivalente eben dieser Pentafulvene handelt.
Spatially Resolved High Voltage Kelvin Probe Force Microscopy: A Novel Avenue for Examining Electrical Phenomena at Nanoscale
Authors: McCluskey Conor J. , Sharma Niyorjyoti , Maguire Jesi R. , Pauly Serene , Rogers Andrew , Lindsay TJ , Holsgrove Kristina M. , Rodriguez Brian J. , Soin Navneet , Gregg John Marty , McQuaid Raymond G. P. , Kumar Amit 
Published: April 2024

AbstractKelvin probe force microscopy (KPFM) is a well‐established scanning probe technique, used to measure surface potential accurately; it has found extensive use in the study of a range of materials phenomena. In its conventional form, KPFM frustratingly precludes imaging samples or scenarios where large surface potential or surface potential gradients exist outside the typical ±10 V window. If the potential regime measurable via KPFM can be expanded, to enable precise and reliable metrology, through a high voltage KPFM (HV‐KPFM) adaptation, it can open up pathways toward a range of novel experiments, where the detection limit of regular KPFM has so far prevented the use of the technique. In this work, HV‐KPFM is realized and shown to be capable of measuring large surface potential and potential gradients with accuracy and precision. The technique is employed to study a range of materials (positive temperature coefficient of resistivity ceramics, charge storage fluoropolymers, and pyroelectrics) where accurate, spatially resolved mapping of surface potential within high voltage regime facilitates novel physical insight. The results demonstrate that HV‐KPFM can be used as an effective tool to fill in existing gaps in surface potential measurements while also opening routes for novel studies in materials physics.
Public human dissection and societal connect of anatomical sciences: A glorious association in the past but ethically forbidden practice at present
Authors: Ghosh Sanjib Kumar , Bhattacharjee Sourav 
Published: April 2024

AbstractUnder the futuristic vision of anatomical sciences, a strong societal connection is mandatory. The anatomical practice experienced robust societal participation through public human dissection from the 16th century onward. With a perspective to explore the intersection of spirituality with anatomy, the present study analyzed this momentous period. From a spiritual perspective, the study also reflects on two relevant but presently uncoupled entities of public human dissection and societal connection through the prism of current regulations. Strong representation from the general public during public human dissection was primarily driven by spiritual proclivity and an endorsement from religious authorities. To regulate large gatherings and maintain academic sanctity, anatomical theaters emerged as dedicated spaces for such a merger. With time and growing financial support, the theaters transformed from temporary structures to elaborate architectural marvels, further propelling already robust societal connections associated with the practice. Nevertheless, a confluence of multiple factors led to the violation of spiritual principles and a consequent decrease in societal participation from the early 18th century, eventually culminating in the demise of such spectacle. Presently, public human dissection—when done—is mostly conducted for commercial gains and in contravention of ethical norms. It is against the essence of spirituality and harbors a bleak prospect for societal connection. Contrastingly, measures adopted to promote societal participation (mostly related to body donation) were quite effective and followed the principles of spirituality. Societal connections served anatomy in the past and can lead to its advancement if approached through a righteous path.
Overview of cloning in lactic acid bacteria: Expression and its application of probiotic potential in inflammatory bowel diseases
Authors: Vivekanandan K. E. , Kasimani R. , Kumar P. Vinoth , Meenatchisundaram S. , Sundar William Arputha 
Published: April 2024

AbstractInflammatory bowel disease (IBD) imposes a significant impact on the quality of life for affected individuals. However, there was a current lack of a systematic summary regarding the latest epidemic trends and the underlying pathogenesis of IBD. This highlights the need for a thorough examination of both the epidemiological aspects of IBD and the specific mechanisms by which lactic acid bacteria (LAB) contribute to mitigating this condition. In developed countries, higher incidences and death rates of IBD have been observed, influenced by a combination of environmental and genetic factors. LAB offer significant advantages and substantial potential for enhancing IBD treatment. LAB's capabilities include the production of bioactive metabolites, regulation of gut immunity, protection of intestinal mechanical barriers, inhibition of oxidative damage, and restoration of imbalanced gut microbiota. The review suggests that screening effective LAB using cell models and metabolites, optimizing LAB intake through dose‐effect studies, enhancing utilization through nanoencapsulation and microencapsulation, investigating mechanisms to deepen the understanding of LAB, and refining clinical study designs. These efforts aim to contribute to comprehending the epidemic trend, pathogenesis, and treatment of IBD, ultimately fostering the development of targeted therapeutic products, such as LAB‐based interventions.
A Bayesian model‐based reduced major axis regression
Authors: Ma Zhihua , Chen Ming‐Hui 
Published: April 2024

AbstractReduced major axis (RMA) regression, widely used in the fields of zoology, botany, ecology, biology, spectroscopy, and among others, outweighs the ordinary least square regression by relaxing the assumption that the covariates are without measurement errors. A Bayesian implementation of the RMA regression is presented in this paper, and the equivalence of the estimates of the parameters under the Bayesian and the frequentist frameworks is proved. This model‐based Bayesian RMA method is advantageous since the posterior estimates, the standard deviations, as well as the credible intervals of the estimates can be obtained through Markov chain Monte Carlo methods directly. In addition, it is straightforward to extend to the multivariate RMA case. The performance of the Bayesian RMA approach is evaluated in the simulation study, and, finally, the proposed method is applied to analyze a dataset in the plantation.