bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis and Properties of Novel Base‐discriminating Fluorescent (BDF) Nucleosides
Authors: Saito Yoshio , Hanawa Kazuo , Hayashi Keigo , Motegi Kaori , Okaoto Akimitsu , Saito Isao 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Condensation Reaction to Unsaturated System, Reduction and Oxidation of (R)‐(‐)‐Carvone: Principal Constituent of Mentha spicata
Authors: Kharchouf S. , Majidi L. , Abraoui H. , Faska Z. 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Four Isotopically Labeled Forms of a Proteasome Inhibitor, Bortezomib
Authors: Li Yuexian , Plesescu Mihaela , Sheehan Patrick , Daniels J. Scott , Prakash Shimoga R. 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Aminothiourea‐Catalyzed Asymmetric Nucleophilic Reactions
Authors: Takemoto Yoshiji , Miyabe Hideto 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tetramic and Tetronic Acids: An Update on New Derivatives and Biological Aspects
Authors: Schobert Rainer , Schlenk Andrea 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Carbonic Anhydrase IX: A New Druggable Target for the Design of Antitumor Agents
Authors: Winum Jean‐Yves , Rami Marouan , Scozzafava Andrea , Montero Jean‐Louis , Supuran Claudiu 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transition Metal‐Catalyzed Carbon—Carbon Bond Formation Suzuki, Heck, and Sonogashira Reactions Using Microwave and Microtechnology
Authors: Singh Brajendra K. , Kaval Nadya , Tomar Shilpi , Van der Eycken Erik , Parmar Virinder S. 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Advances in Selective α1‐Adrenoreceptor Antagonists as Antihypertensive Agents
Authors: Jain Kishor S. , Bariwal Jitender B. , Kathiravan Muthu K. , Phoujdar Manisha S. , Sahne Rajkumari S. , Chauhan Bishram S. , Shah Anamik K. , Yadav Mange Ram 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Metal‐Catalyzed Reactions of Organoboron Compounds in Organic Syntheses
Authors: Yamamoto Yasunori , Miyaura Norio 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Recyclable Catalytic System for Green Oxidation Using Temperature‐Responsive Catalysts
Authors: Hamamoto Hiromi , Ikegami Shiro 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: DNAzymes for Sensing, Nanobiotechnology and Logic Gate Applications
Authors: Willner Itamar , Shlyahovsky Bella , Zayats Maya , Willner Bilha 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
Authors: Que Emily L. , Domaille Dylan W. , Chang Christopher J. 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Offgas Recycle for Increased Heat Production from Aerobic Thermophilic Treatment of Swine Waste: Pilot Studies and Full‐Scale Design
Authors: Blackburn James W. , Wang Zhe , Mudragaddam Mahesh 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Coumarin Assemblies in Solid State
Authors: Padilla‐Martinez Itzia I. , Martinez‐Martinez Francisco J. , Garcia‐Baez Efren V. 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photocontrol of Neural Activity: Biophysical Mechanisms and Performance in vivo
Authors: Sjulson Lucas , Miesenboeck Gero 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Why Is It Important to Simultaneously Use More than One Chiroptical Spectroscopic Method for Determining the Structures of Chiral Molecules?
Authors: Polavarapu Prasad L. 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Biomarkers for Drug Discovery: Important Aspects of in vitro Assay Design for HTS and HCS Bioassays
Authors: Irwin William A. , Jelic Dubravko , Antolovic Roberto 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Single Molecule Probing of Exocytotic Protein Interactions Using Force Spectroscopy
Authors: Montana Vedrana , Liu Wei , Mohideen Umar , Parpura Vladimir 
Published: July 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Eating disorder symptoms among undergraduate varsity athletes, club athletes, independent exercisers, and nonexercisers
Authors: Holm‐Denoma Jill M. , Scaringi Vanessa , Gordon Kathryn H. , Van Orden Kimberly A. , Joiner Thomas E. 
Published: July 2008

AbstractObjective:To examine whether differences in eating disorder symptoms exist between women who are varsity athletes, club athletes, independent exercisers, and nonexercisers and to determine whether sports anxiety moderates any observed between‐group effects.Method:Two hundred seventy four female undergraduates completed the eating disorders inventory and the physical activity and sport anxiety scale and reported their exercise habits.Results:Women who participated in sports tended to have higher levels of eating disorder symptomatology than those who did not. Higher levels of sports anxiety were predictive of higher levels of bulimic symptoms and drive for thinness. Finally, the interaction of sports anxiety and level of athletic participation significantly predicted body dissatisfaction and bulimic symptoms.Conclusion:Coaches and clinicians should be aware that athletes experience higher rates of eating disorder symptoms than nonathletes. Moreover, sports anxiety should be considered as a possible target of therapy among athletes. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2009
Reactivity of (Mono‐tert‐butyloxiranyl)lithium: A Theoretical Ab Initio Study
Authors: Bouyacoub Abdelatif , Hadjadj‐Aoul Ratiba , Volatron François 
Published: July 2008

AbstractThe reactivity of the lithiated tert‐butyloxiranyl anion has been studied by means of ab initio calculations at the CCSD(T)//MP2 level of theory. Four reaction paths have been studied (three ring‐opening reactions and one addition reaction). All extrema were located and characterised. The effects of solvation by one or two MeLi molecules were studied for each reaction path by reoptimising the various extrema. It was found that the addition reaction path becomes competitive when at least two MeLi molecules are taken into account. This shows the catalytic effect of alkyllithium on this reaction path. In no case could a free carbene be characterised as a reaction intermediate. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Vanadium(V) Salen Complex Catalyzed Highly Enantioselective Cyanoformylation of Aldehydes in the Presence of Imidazole as a Cocatalyst
Authors: Khan Noor‐ul H. , Agrawal Santosh , Kureshy Rukhsana I. , Abdi Sayed H. R. , Prathap K. Jeya , Jasra Raksh V. 
Published: July 2008

AbstractHighly enantioselective cyanoformylation of aldehydes catalyzed by VV chiral salen complex by using ethyl cyanoformate as a source of cyanide was accomplished in the presence of several cocatalysts. Excellent yields and ee values for the resulting cyanohydrin carbonates were achieved when imidazole was used as a cocatalyst at –20 °C. The ee value of the cyanohydrin carbonate of 2‐naphthaldehyde was further improved to >99 % by recrystallization. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Starting electroosmotic flow in an annulus and in a rectangular channel
Authors: Chang Chien C. , Wang Chang Yi 
Published: July 2008

AbstractThe initial electroosmotic flow through a small pore or microchannel with annular or rectangular cross section is studied under the Debye‐Hückel approximation. Analytical series solutions and their asymptotic behavior for small and large non‐dimensional electrokinetic widths are found for these two basic cases. The explicit and accurate solutions are particularly useful for examining various geometric/physical effects on the transient time scales and the flow rates for the transient states. The steady flow rate of the smaller channel may be disproportionately smaller than a reference channel if the electric double layer is thick, but will be in close proportion to the area ratio if the electric double layer is thin. A smaller channel compared to a reference channel has a shorter transient time scale, and the transient flow has characters very different from the steady state if the electric double layer is thin. The total transient flow rate of several smaller pores or channels may exceed largely that of a single large pore or channel with the same total cross section on the transient time scale of the smaller channels. The results have important implications on liquid transport in micropores or channels by pulse voltages or more general time‐varying voltages.
Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly
Authors: Gkretsi Vasiliki , Apte Udayan , Mars Wendy M. , Bowen William C. , Luo Jian-Hua , Yang Yu , Yu Yan P. , Orr Ann , St.-Arnaud René , Dedhar Shoukat , Kaestner Klaus H. , Wu Chuanyue , Michalopoulos George K. 
Published: July 2008

Abstract

Hepatocyte differentiation and proliferation are greatly affected by extracellular matrix (ECM). Primary hepatocytes cultured without matrix dedifferentiate over time, but matrix overlay quickly restores differentiation. ECM also is critical in liver regeneration where ECM degradation and reconstitution are steps in the regenerative process. Integrin-linked kinase (ILK) is a cell-ECM-adhesion component implicated in cell–ECM signaling by means of integrins. We investigated the role of ILK in whole liver by using the LoxP/Cre model system. ILK was eliminated from the liver by mating homozygous ILK-floxed animals with mice expressing Cre-recombinase under control of the α fetoprotein enhancer and albumin promoter. After ablation of ILK, animals are born normal. Soon after birth, however, they develop histologic abnormalities characterized by disorderly hepatic plates, increased proliferation of hepatocytes and biliary cells, and increased deposition of extracellular matrix. Cell proliferation is accompanied by increased cytoplasmic and nuclear stabilization of β-catenin. After this transient proliferation of all epithelial components, proliferation subsides and final liver to body weight ratio in livers with ILK deficient hepatocytes is two times that of wild type. Microarray analysis of gene expression during the stage of cell proliferation shows up-regulation of integrin and matrix-related genes and a concurrent down-regulation of differentiation-related genes. After the proliferative stage, however, the previous trends are reversed resulting in a super-differentiated phenotype in the ILK-deficient livers.

Conclusion:

Our results show for the first time

in vivo

the significance of ILK and hepatic ECM-signaling for regulation of hepatocyte proliferation and differentiation. (Hepatology 2008;48:1932-1941.)
Bile duct proliferation in Jag1 /fringe heterozygous mice identifies candidate modifiers of the alagille syndrome hepatic phenotype
Authors: Ryan Matthew J. , Bales Christina , Nelson Anthony , Gonzalez Dorian M. , Underkoffler Lara , Segalov Michelle , Wilson-Rawls Jeanne , Cole Susan E. , Moran Jennifer L. , Russo Pierre , Spinner Nancy B. , Kusumi Kenro , Loomes Kathleen M. 
Published: July 2008

Abstract

Alagille syndrome (AGS) is a heterogeneous developmental disorder associated with bile duct paucity and various organ anomalies. The syndrome is caused by mutations in

JAG1

, which encodes a ligand in the Notch signaling pathway, in the majority of cases and mutations in the

NOTCH2

receptor gene in less than 1% of patients. Although a wide array of

JAG1

mutations have been identified in the AGS population, these mutational variants have not accounted for the wide phenotypic variability observed in patients with this syndrome. The Fringe genes encode glycosyltransferases, which modify Notch and alter ligand-receptor affinity. In this study, we analyzed double heterozygous mouse models to examine the Fringe genes as potential modifiers of the Notch-mediated hepatic phenotype observed in AGS. We generated mice that were haploinsufficient for both

Jag1

and one of three paralogous Fringe genes: Lunatic (

Lfng

), Radical (

Rfng

), and Manic (

Mfng

). Adult

Jag1

+/−

Lfng

+/− and

Jag1

+/−

Rfng

+/− mouse livers exhibited widespread bile duct proliferation beginning at 5 weeks of age and persisting up to 1 year. The

Jag1

+/−

Mfng

+/− livers showed a subtle, yet significant increase in bile duct numbers and bile duct to portal tract ratios. These abnormalities were not observed in the newborn period. Despite the portal tract expansion by bile ducts, fibrosis was not increased and epithelial to mesenchymal transition was not shown in the affected portal tracts.

Conclusion:

Mice heterozygous for mutations in

Jag1

and the Fringe genes display striking bile duct proliferation, which is not apparent at birth. These findings suggest that the Fringe genes may regulate postnatal bile duct growth and remodeling, and serve as candidate modifiers of the hepatic phenotype in AGS. (Hepatology 2008;48:1989–1997.)
Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathway
Authors: Walden Hannah R. , Kirby John A. , Yeaman Stephen J. , Gray Joe , Jones David E. , Palmer Jeremy M. 
Published: July 2008

Abstract

Lipoylated enzymes such as the E2 component of pyruvate dehydrogenase complex (PDC-E2) are targets for autoreactive immune responses in primary biliary cirrhosis, with lipoic acid itself forming a component of the dominant auto-epitopes. A candidate mechanism for the initiation of tolerance breakdown in this disease is immune recognition of neo-antigens formed by xenobiotic substitution of normal proteins. Importantly, sensitization with proteins artificially substituted with the lipoic acid analogue xenobiotic 6-bromohexanoic acid (6BH) can induce an immune response that cross-reacts with PDC-E2. This study investigated the potential of recombinant lipoylation enzymes lipoate activating enzyme and lipoyl-AMP(GMP):

N

-lysine lipoyl transferase to aberrantly incorporate xenobiotics into PDC-E2. It was found that these enzymes could incorporate lipoic acid analogues including octanoic and hexanoic acids and the xenobiotic 6BH into PDC-E2. The efficiency of incorporation of these analogues showed a variable dependence on activation by adenosine triphosphate (ATP) or guanosine triphosphate (GTP), with ATP favoring the incorporation of hexanoic acid and 6BH whereas GTP enhanced substitution by octanoic acid. Importantly, competition studies showed that the relative incorporation of both 6BH and lipoic acid could be regulated by the balance between ATP and GTP, with the formation of 6BH-substituted PDC-E2 predominating in an ATP-rich environment.

Conclusion:

Using a well-defined system

in vitro

we have shown that an important xenobiotic can be incorporated into PDC in place of lipoic acid by the exogenous lipoylation system; the relative levels of lipoic acid and xenobiotic incorporation may be determined by the balance between ATP and GTP. These observations suggest a clear mechanism for the generation of an auto-immunogenic neo-antigen of relevance for the pathogenesis of primary biliary cirrhosis. (Hepatology 2008;48:1874-1884.)
Overexpression of mineralocorticoid and transdominant glucocorticoid receptor blocks the impairing effects of glucocorticoids on memory
Authors: Ferguson Deveroux , Sapolsky Robert 
Published: July 2008

AbstractIt is well established that mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) influence hippocampal‐dependent spatial memory. MRs are saturated in the presence of low corticosterone (CORT) levels; consequently receptor protein levels play a rate‐limiting role in regulating the positive effects of MR‐mediated gene transcription. In this study, viral vector‐mediated transgene expression was used to simultaneously manipulate both MR and GR signaling. This approach allowed us to investigate the effects of spatially restricted overexpression of MR and a negative transdominant GR (TD) in the dentate gyrus (DG) subfield of the hippocampus, on short term and long term spatial memory in animals overexpressing one copy of MR or TD, two copies of MR (“MR/MR”), or one copy of each (“MR/TD”). Expression of transgenes did not influence the acquisition (learning) phase of the Morris water maze task. However, we found an overall enhancing effect of MR/MR expression on short term memory performance. In addition, rats expressing TD and MR/TD blocked the high CORT‐induced impairments on long term spatial memory retrieval. These findings illustrate the potential beneficial effects of increasing MR signaling or decreasing GR signaling to enhance specific aspects of cognitive function. © 2008 Wiley‐Liss, Inc.
Reduced cholinergic status in hippocampus produces spatial memory deficits when combined with kainic acid induced seizures
Authors: Craig Laura A. , Hong Nancy S. , Kopp Joelle , McDonald Robert J. 
Published: July 2008

AbstractAlzheimer's disease is the most common form of dementia in North America today. Though many risk factors have been suggested to increase the likelihood of developing this disease, an accurate etiology has yet to be described. One of these risk factors commonly associated with Alzheimer's disease is the loss of cholinergic neurons of the medial septum that project to the hippocampus, leading to depletion in cholinergic activity. A second risk factor is the presence of seizures, which can increase the risk of excitotoxic cell death. To examine the interaction between these two common risk factors, we gave rats a focal cholinergic lesion of the medial septum using the specific immunotoxin 192‐IgG Saporin, followed 2 weeks later by a non‐convulsive dose of kainic acid. We then assessed the rats for seizure severity, hippocampal damage and performance on a spatial memory task. The combination of the two factors resulted in a trend towards increased seizure severity in the cholinergic depleted rats, but more importantly, the lesioned rats that had non‐convulsive seizures were significantly impaired on a spatial version of the Morris water maze when compared with either the rats with a cholinergic depletion or non‐convulsive seizure alone. This result could not be explained by seizure severity or the extent of hippocampal damage, suggesting a more subtle interaction between these two risk factors in the development of a hippocampal based memory impairment. © 2008 Wiley‐Liss, Inc.