bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effort–reward imbalance and incidence of low back and neck injuries in San Francisco transit operators
Authors: Rugulies R , Krause N 
Published: December 2007

Objectives:Effort–reward imbalance (ERI) has been associated with musculoskeletal disorders in cross-sectional and case–control studies, but no longitudinal studies have been published yet. The effect of ERI on the incidence of compensated low back and neck injuries was examined in a 7.5-year follow-up study among 1179 San Francisco transit operators.Methods:Data from medical examination and a survey on working conditions and health were linked to administrative workers’ compensation databases. HRs for first low back and first neck injury were calculated with multivariate Cox regression models. Additional analyses accounted for severity of injury based on medical diagnosis.Results:A 1 SD increase in ERI was associated with compensated low back (HR 1.13, 95% CI 1.02 to 1.26) and neck injuries (HR 1.14, 95% CI 1.02 to 1.27) after adjusting for gender, age, height, weight, years of professional driving, weekly driving hours, vehicle type, ergonomic problems, pain at baseline and job strain. The highest quartile of ERI showed an HR of 1.32 (95% CI 0.94 to 1.86) for low back injuries and an HR of 1.66 (95% CI 1.16 to 2.38) for neck injuries after adjustment for all covariates. The associations between ERI and low back injury were stronger for more severe injuries (HR 1.23, 95% CI 1.03 to 1.46 for a 1 SD increase in ERI) than for less severe injuries (HR 1.11, 95% CI 0.96 to 1.28). For neck injuries, stronger relationships were found for less severe injuries (HR 1.15, 95% CI 1.02 to 1.29) than for more severe injuries (HR 1.10, 95% CI 0.86 to 1.41).Conclusions:ERI is associated with low back and neck injuries in San Francisco transit operators independently of individual worker characteristics, physical workload, ergonomic problems, baseline pain and job strain. Effect sizes differ by injury severity.
How common is repetitive strain injury?
Authors: Palmer K T , Reading I , Calnan M , Coggon D 
Published: December 2007

Objective:Statistics from Labour Force Surveys are widely quoted as evidence for the scale of occupational illness in Europe. However, occupational attribution depends on whether participants believe their health problem is caused or aggravated by work, and personal beliefs may be unreliable. The authors assessed the potential for error for work-associated arm pain.Methods:A questionnaire was emailed to working-aged adults, randomly chosen from five British general practices. They were asked about: occupational activities; mental health; self-rated health; arm pain; and beliefs about its causation. Those in work (n = 1769) were asked about activities likely to cause arm pain, from which the authors derived a variable for exposure to any “arm-straining” occupational activity. The authors estimated the relative risk (RR) from arm-straining activity, using a modified Cox model, and derived the population attributable fraction (PAF). They compared the proportion of arm pain cases reporting their symptom as caused or made worse by work with the calculated PAF, overall and for subsets defined by demographic and other characteristics.Results:Arm pain in the past year was more common in the 1143 subjects who reported exposure to arm-straining occupational activity (RR 1.2, 95% CI 1.1 to 1.5). In the study sample as a whole, 53.9% of 817 cases reported their arm pain as work-associated, whereas the PAF for arm-straining occupational activity was only 13.9%. The ratio of cases reported as work-related to the calculated attributable number was substantially higher below 50 years (5.4) than at older ages (3.0) and higher in those with worse self-rated and mental health.Conclusions:Counting people with arm pain which they believe to be work-related can overestimate the number of cases attributable to work substantially. This casts doubt on the validity of a major source of information used by European governments to evaluate their occupational health strategies.
Evaluation of the need for endoscopy to identify low-risk patients presenting with an acute upper gastrointestinal bleed suitable for early discharge
Authors: Robins G G , Sarwar M S , Armstrong M , Denyer M E , Bush S , Hassan T , Everett S M 
Published: December 2007

Abstract

Aims
To audit the safety of differing protocol-driven early-discharge policies, from two sites, for low-risk acute upper gastrointestinal (GI) bleeding and determine if default early (&lt;24 h) in-patient endoscopy is necessary.

Methods
All patients with low-risk acute upper GI bleeding presenting to two separate hospital sites in Leeds from August 2002 to March 2005 were identified. Both hospitals operate nurse-led process-driven protocols for discharge within 24 h, but only one includes default endoscopy. Relevant information was obtained from patients' notes, patient administration systems, discharge letters and endoscopy records.

Results
120 patients were admitted to site A and 74 to site B. Median length of stay on the clinical decisions unit was 12.6 h at site A and 9.4 h at site B (p = 0.045). Oesophagogastroduodenoscopy was performed on 89/120 (74%) patients at site A compared with only 7/74 (9%) at site B (p&lt;0.001). Six of 120 (5%) patients from site A were admitted to hospital for further observation compared with 6/74 (8%) from site B (p = 0.38). Of the remaining patients, all were discharged within 24 h, and 8/114 (7%) at site A vs 17/68 (25%) at site B were given hospital clinic follow-up (p&lt;0.001). None of the 194 patients had further bleeding or complications within 30 days.

Conclusions
Patients admitted with a low-risk acute upper GI bleeding can be managed safely by a nurse-led process-driven protocol, based on readily available clinical and laboratory variables, with early discharge &lt;24 h. Avoiding in-patient endoscopy appears to be safe but at the price of greater clinic follow-up.
Empirical Models of the Probability Distribution of Sea Surface Wind Speeds
Authors: Monahan Adam Hugh 
Published: December 2007

Abstract
This study considers the probability distribution of sea surface wind speeds, which have historically been modeled using the Weibull distribution. First, non-Weibull structure in the observed sea surface wind speeds (from SeaWinds observations) is characterized using relative entropy, a natural information theoretic measure of the difference between probability distributions. Second, empirical models of the probability distribution of sea surface wind speeds, parameterized in terms of the parameters of the vector wind probability distribution, are developed. It is shown that Gaussian fluctuations in the vector wind cannot account for the observed features of the sea surface wind speed distribution, even if anisotropy in the fluctuations is accounted for. Four different non-Gaussian models of the vector wind distribution are then considered: the bi-Gaussian, the centered gamma, the Gram–Charlier, and the constrained maximum entropy. It is shown that so long as the relationship between the skewness and kurtosis of the along-mean sea surface wind component characteristic of observations is accounted for in the modeled probability distribution, then all four vector wind distributions are able to simulate the observed mean, standard deviation, and skewness of the sea surface wind speeds with an accuracy much higher than is possible if non-Gaussian structure in the vector winds is neglected. The constrained maximum entropy distribution is found to lead to the best simulation of the wind speed probability distribution. The significance of these results for the parameterization of air/sea fluxes in general circulation models is discussed.
Timely Detection of Changes in the Meridional Overturning Circulation at 26°N in the Atlantic
Authors: Baehr Johanna , Haak Helmuth , Alderson Steven , Cunningham Stuart A. , Jungclaus Johann H. , Marotzke Jochem 
Published: December 2007

Abstract
It is investigated how changes in the North Atlantic meridional overturning circulation (MOC) might be reliably detected within a few decades, using the observations provided by the RAPID-MOC 26°N array. Previously, detectability of MOC changes had been investigated with a univariate MOC time series exhibiting strong internal variability, which would prohibit the detection of MOC changes within a few decades. Here, a modification of K. Hasselmann’s fingerprint technique is used: (simulated) observations are projected onto a time-independent spatial pattern of natural variability to derive a time-dependent detection variable. The fixed spatial pattern of natural variability is derived by regressing the zonal density gradient along 26°N against the strength of the MOC at 26°N within the coupled ECHAM5/Max Planck Institute Ocean Model’s (MPI-OM) control climate simulation. This pattern is confirmed against the observed anomalies found between the 1957 and the 2004 hydrographic occupations of the section. Onto this fixed spatial pattern of natural variability, both the existing hydrographic observations and simulated observations mimicking the RAPID-MOC 26°N array in three realizations of the Intergovernmental Panel on Climate Change (IPCC) scenario A1B are projected. For a random observation error of 0.01 kg m−3, and only using zonal density gradients between 1700- and 3100-m depth, statistically significant detection occurs with 95% reliability after about 30 yr, in the model and climate change scenario analyzed here. Compared to using a single MOC time series as the detection variable, continuous observations of zonal density gradients reduce the detection time by 50%. For the five hydrographic occupations of the 26°N transect, none of the analyzed depth ranges shows a significant trend between 1957 and 2004, implying that there was no MOC trend over the past 50 yr.
Atmosphere and Marginal-Sea Interaction Leading to an Interannual Variation in Cold-Air Outbreak Activity over the Japan Sea
Authors: Isobe Atsuhiko , Beardsley Robert C. 
Published: December 2007

Abstract
The interannual variation in cold-air outbreak activity over the Japan Sea is investigated using Japan Meteorological Agency buoy 21002 and Quick Scatterometer (QuikSCAT) wind data, Japan Oceanographic Data Center sea surface temperature (SST) data, NCEP–NCAR reanalysis surface wind and sea level pressure (SLP) data, and the winter Arctic Oscillation (AO) index of Thompson and Wallace. Cold-air outbreaks occur during the “winter” November–March period, and wind data for this season for the 19-winter period 1981–2000 were analyzed. Wavelet spectra averaged between 5- and 15-day periods were used to evaluate the intensity of cold-air outbreaks quantitatively. The winter mean wavelet spectra exhibited a clear interannual variation and a significant positive correlation with the AO index, indicating that intensive cold-air outbreaks frequently occur during relatively warm winters caused by a quasi-decadal AO. Based on the SST and SLP data, the low atmospheric surface pressure disturbances tend to develop over the warm East China Sea in warm winters in the positive AO phase. As these low SLP disturbances advance toward the northern Japan islands during the positive AO phase, they intensify more, leading to stronger cold-air outbreaks over the Japan Sea and increased sea surface cooling over the northern Japan Sea.
Wind Stress Drag Coefficient over the Global Ocean*
Authors: Kara A. Birol , Wallcraft Alan J. , Metzger E. Joseph , Hurlburt Harley E. , Fairall Chris W. 
Published: December 2007

Abstract
Interannual and climatological variations of wind stress drag coefficient (CD) are examined over the global ocean from 1998 to 2004. Here CD is calculated using high temporal resolution (3- and 6-hourly) surface atmospheric variables from two datasets: 1) the 40-yr European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA-40) and 2) the Navy Operational Global Atmospheric Prediction System (NOGAPS). The stability-dependent CD algorithm applied to both datasets gives almost identical values over most of the global ocean, confirming the validity of results. Overall, major findings of this paper are as follows: 1) the CD value can change significantly (e.g., &gt;50%) on 12-hourly time scales around the Kuroshio and Gulf Stream current systems; 2) there is strong seasonal variability in CD, but there is not much interannual change in the spatial variability for a given month; 3) a global mean CD ≈ 1.25 × 10−3 is found in all months, while CD ≥ 1.5 × 10−3 is prevalent over the North Pacific and North Atlantic Oceans and in southern high-latitude regions as well, and CD ≤ 1.0 × 10−3 is typical in the eastern equatorial Pacific cold tongue; and 4) including the effects of air–sea stability on CD generally causes an increase of &gt;20% in comparison to the one calculated based on neutral conditions in the tropical regions. Finally, spatially and temporally varying CD fields are therefore needed for a variety of climate and air–sea interaction studies.
Feedback of Tropical Instability-Wave-Induced Atmospheric Variability onto the Ocean
Authors: Seo Hyodae , Jochum Markus , Murtugudde Raghu , Miller Arthur J. , Roads John O. 
Published: December 2007

Abstract
The effects of atmospheric feedbacks on tropical instability waves (TIWs) in the equatorial Atlantic Ocean are examined using a regional high-resolution coupled climate model. The analysis from a 6-yr hindcast from 1999 to 2004 reveals a negative correlation between TIW-induced wind perturbations and TIW-induced ocean currents, which implies damping of the TIWs. On the other hand, the feedback effect from the modification of Ekman pumping velocity by TIWs is small compared to the contribution to TIW growth by baroclinic instability. Overall, the atmosphere reduces the growth of TIWs by adjusting its wind response to the evolving TIWs. The analysis also shows that including ocean current (mean + TIWs) in the wind stress parameterization reduces the surface stress estimate by 15%–20% over the region of the South Equatorial Current. Moreover, TIW-induced perturbation ocean currents can significantly alter surface stress estimations from scatterometers, especially at TIW frequencies. Finally, the rectification effect from the atmospheric response to TIWs on latent heat flux is small compared to the mean latent heat flux.
Engaging with Discourse on Caste, Class and Politics in India
Authors: Pankaj Ashok K. 
Published: December 2007

This article maps the changing profile of pre-Mandal and post-Mandal debates on caste, class and politics in India, showing that the centrality of caste as an agent of politics and its dominant role in public-political life has remained a reality throughout. What is contested now is the extent to which recognition of caste as an instrument of socio-political change (following the Mandal Commission) and caste-centric socio-political movements of the 1980s and 1990s (the Dalit and Backward Class movements) has reinforced caste-centric public-political life by giving it a modern value and a secular purpose. The article argues that the contemporary elaborate discourses on caste, class, and politics in India should seek to develop new paradigms for the discussion of caste and should interrogate more vigorously the democratic and secular roles of caste in relation to class and politics.
Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins
Authors: Takeda Kotaro , Aguila Hector L. , Parikh Nehal S. , Li Xiping , Lamothe Katie , Duan Li-Juan , Takeda Hiromi , Lee Frank S. , Fong Guo-Hua 
Published: December 2007

Abstract
Polycythemia is often associated with erythropoietin (EPO) overexpression and defective oxygen sensing. In normal cells, intracellular oxygen concentrations are directly sensed by prolyl hydroxylase domain (PHD)–containing proteins, which tag hypoxia-inducible factor (HIF) α subunits for polyubiquitination and proteasomal degradation by oxygen-dependent prolyl hydroxylation. Here we show that different PHD isoforms differentially regulate HIF-α stability in the adult liver and kidney and suppress Epo expression and erythropoiesis through distinct mechanisms. Although Phd1−/− or Phd3−/− mice had no apparent defects, double knockout of Phd1 and Phd3 led to moderate erythrocytosis. HIF-2α, which is known to activate Epo expression, accumulated in the liver. In adult mice deficient for PHD2, the prototypic Epo transcriptional activator HIF-1α accumulated in both the kidney and liver. Elevated HIF-1α levels were associated with dramatically increased concentrations of both Epo mRNA in the kidney and Epo protein in the serum, which led to severe erythrocytosis. In contrast, heterozygous mutation of Phd2 had no detectable effects on blood homeostasis. These findings suggest that PHD1/3 double deficiency leads to erythrocytosis partly by activating the hepatic HIF-2α/Epo pathway, whereas PHD2 deficiency leads to erythrocytosis by activating the renal Epo pathway.
Incudomalleal joint formation: the roles of apoptosis, migration and downregulation
Authors: Amin Susan , Matalova Eva , Simpson Carol , Yoshida Hiroki , Tucker Abigail S 
Published: December 2007

Abstract

Background
The middle ear of mammals is composed of three endochondrial ossicles, the stapes, incus and malleus. Joints link the malleus to the incus and the incus to the stapes. In the mouse the first arch derived malleus and incus are formed from a single Sox9 and Type II collagen expressing condensation that later subdivides to give rise to two separate ossicles. In contrast the stapes forms from a separate condensation derived from the second branchial arch. Fusion of the malleus and incus is observed in a number of human syndromes and results in conductive hearing loss. Understanding how this joint forms during normal development is thus an important step in furthering our understanding of such defects.

Results
We show that the developing incudomalleal joint is characterised by a lack of proliferation and discrete areas of apoptosis. Apoptosis has been suggested to aid in the removal of pre-cartilaginous cells from the joint region, allowing for the physical separation of the cartilaginous elements, however, we show that joint initiation is unaffected by blocking apoptosis. There is also no evidence of cell migration out of the presumptive joint region, as observed by labelling of joint and ossicle cells in culture. Using Type II collagen lacZ reporter mice, however, it is evident that cells in the presumptive joint region remain in place and downregulate cartilage markers.

Conclusion
The malleus and incus first appear as a single united condensation expressing early cartilage markers. The incudomalleal joint region forms by cells in the presumptive joint region switching off cartilage markers and turning on joint markers. Failure in this process may result in fusion of this joint, as observed in human syndromes such as Branchio-Oto-Renal Syndrome or Treacher Collins Syndrome.
Genome-wide interacting effects of sucrose and herbicide-mediated stress in Arabidopsis thaliana: novel insights into atrazine toxicity and sucrose-induced tolerance
Authors: Ramel Fanny , Sulmon Cécile , Cabello-Hurtado Francisco , Taconnat Ludivine , Martin-Magniette Marie-Laure , Renou Jean-Pierre , El Amrani Abdelhak , Couée Ivan , Gouesbet Gwenola 
Published: December 2007

Abstract

Background
Soluble sugars, which play a central role in plant structure and metabolism, are also involved in the responses to a number of stresses, and act as metabolite signalling molecules that activate specific or hormone-crosstalk transduction pathways. The different roles of exogenous sucrose in the tolerance of Arabidopsis thaliana plantlets to the herbicide atrazine and oxidative stress were studied by a transcriptomic approach using CATMA arrays.

Results
Parallel situations of xenobiotic stress and sucrose-induced tolerance in the presence of atrazine, of sucrose, and of sucrose plus atrazine were compared. These approaches revealed that atrazine affected gene expression and therefore seedling physiology at a much larger scale than previously described, with potential impairment of protein translation and of reactive-oxygen-species (ROS) defence mechanisms. Correlatively, sucrose-induced protection against atrazine injury was associated with important modifications of gene expression related to ROS defence mechanisms and repair mechanisms. These protection-related changes of gene expression did not result only from the effects of sucrose itself, but from combined effects of sucrose and atrazine, thus strongly suggesting important interactions of sucrose and xenobiotic signalling or of sucrose and ROS signalling.

Conclusion
These interactions resulted in characteristic differential expression of gene families such as ascorbate peroxidases, glutathione-S-transferases and cytochrome P450s, and in the early induction of an original set of transcription factors. These genes used as molecular markers will eventually be of great importance in the context of xenobiotic tolerance and phytoremediation.
NMR and X-ray analysis of structural additivity in metal binding site-swapped hybrids of rubredoxin
Authors: LeMaster David M , Anderson Janet S , Wang Limin , Guo Yi , Li Hongmin , Hernández Griselda 
Published: December 2007

Abstract

Background
Chimeric hybrids derived from the rubredoxins of Pyrococcus furiosus (Pf) and Clostridium pasteurianum (Cp) provide a robust system for the characterization of protein conformational stability and dynamics in a differential mode. Interchange of the seven nonconserved residues of the metal binding site between the Pf and Cp rubredoxins yields a complementary pair of hybrids, for which the sum of the thermodynamic stabilities is equal to the sum for the parental proteins. Furthermore, the increase in amide hydrogen exchange rates for the hyperthermophile-derived metal binding site hybrid is faithfully mirrored by a corresponding decrease for the complementary hybrid that is derived from the less thermostable rubredoxin, indicating a degree of additivity in the conformational fluctuations that underlie these exchange reactions.

Results
Initial NMR studies indicated that the structures of the two complementary hybrids closely resemble "cut-and-paste" models derived from the parental Pf and Cp rubredoxins. This protein system offers a robust opportunity to characterize differences in solution structure, permitting the quantitative NMR chemical shift and NOE peak intensity data to be analyzed without recourse to the conventional conversion of experimental NOE peak intensities into distance restraints. The intensities for 1573 of the 1652 well-resolved NOE crosspeaks from the hybrid rubredoxins were statistically indistinguishable from the intensities of the corresponding parental crosspeaks, to within the baseplane noise level of these high sensitivity data sets. The differences in intensity for the remaining 79 NOE crosspeaks were directly ascribable to localized dynamical processes. Subsequent X-ray analysis of the metal binding site-swapped hybrids, to resolution limits of 0.79 Å and 1.04 Å, demonstrated that the backbone and sidechain heavy atoms in the NMR-derived structures lie within the range of structural variability exhibited among the individual molecules in the crystallographic asymmetric unit (~0.3 Å), indicating consistency with the "cut-and-paste" structuring of the hybrid rubredoxins in both crystal and solution.

Conclusion
Each of the significant energetic interactions in the metal binding site-swapped hybrids appears to exhibit a 1-to-1 correspondence with the interactions present in the corresponding parental rubredoxin structure, thus providing a structural basis for the observed additivity in conformational stability and dynamics. The congruence of these X-ray and NMR experimental data offers additional support for the interpretation that the conventional treatment of NOE distance restraints contributes substantially to the systematic differences that are commonly reported between NMR- and X-ray-derived protein structures.