bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photochemische Cobaltkatalysierte Synthese von Heterozyklen durch die Zykloisomerisierung Nichtaktivierter Olefine
Authors: Lindner Henry , Amberg Willi M. , Martini Tristano , Fischer David M. , Moore Eléonore , Carreira Erick M. 
Published: February 2024

AbstractEine allgemeine, intramolekulare Zykloisomerisierung nichtaktivierter Olefine mit Nukleophilen wird beschrieben. Die Reaktion erfolgt unter milden Bedingungen und toleriert Ether, Ester, geschützte Amine, Acetale, Pyrazole, Carbamate und Arene. Sie ist zugänglich für N‐, O‐ und C‐Nukleophile, wobei eine Reihe verschiedener Heterozyklen gebildet werden kann, darunter Pyrrolidine, Piperidine, Oxazolidinone und Lactone. Durch die Kombination eines Benzothiazinoquinoxalins als Organophotokatalysator und eines Cobaltsalen‐Katalysators sind keine stöchiometrischen Oxidations‐ oder Reduktionsmittel erforderlich. Wir zeigen den Nutzen des Protokolls für die Diversifizierung von Arzneimitteln sowie die Synthese mehrerer kleiner Naturstoffe.
Synthesis and characterization of polylactic acid‐lecithin‐starch bioplastic film
Authors: Mukaila Taofeek , Adeniyi Adewale , Bello Ibrahim , Sarker Niloy Chandra , Monono Ewumbua , Hammed Ademola 
Published: February 2024

AbstractPlastic‐induced environmental issues could be solved using biomaterials, such as polylactic acid (PLA) film. PLA film is a costly solution suggesting the need to add less expensive starch. However, PLA and starch do not mix due to their diverging water behavior. In this study, we evaluated the impact of lecithin as a compatibilizer in varying ratio of PLA and starch film. The results show that inclusion of lecithin in PLA/starch composite leads to enhanced mechanical properties compared with the composite without lecithin. All films' thermal properties were stable but the thermograph of PLA/starch display two peaks whose distance is impacted by lecithin. In addition, morphology and functional group fingerprints revealed that the addition of lecithin improved the interfacial adhesion between the two polymers. Lecithin influenced the positioning and dispersion pattern of starch granules and distinct transmittance characteristics. The improved compatibility of PLA/starch makes the resulting films less susceptible to water penetration and dissolution. This work demonstrated the possibility of using lecithin as emulsifier between PLA and starch which could expand the application of PLA/starch film especially in packaging industries and bale net wrapping.
Non‐isothermal crystallization kinetic of recycled PET and its blends with PBT modified with epoxy‐based multifunctional chain extender
Authors: Himmelsbach Andreas , Brütting Christian , Akdevelioglu Yavuz , Albuquerque Rodrigo Q. , Nofar Mohammadreza , Ruckdäschel Holger 
Published: February 2024

AbstractA fundamental understanding of crystallization behavior is essential for the processing of both virgin and recycled polymers. This research delves into the crystallization characteristics and non‐isothermal crystallization kinetics of recycled polyethylene terephthalate (rPET) and its blends with poly butylene terephthalate (PBT), which have been modified using epoxy‐based multifunctional chain extenders (CE). The preparation of rPET/PBT blends involved a twin‐screw extruder, with varying weight ratios and different CE concentrations. Differential scanning calorimetry was employed to perform crystallization analysis on the samples. The results underscore the profound impact of blend composition on the thermal characteristics of the system, with CE exerting only a marginal influence. The glass transition temperatures (Tg) of the two polymers were measured at 49 and 79°C. During blending, the Tg values demonstrated variations relative to the proportions but did not adhere to the Fox equation. Furthermore, PBT was found to enhance the crystallization tendencies of rPET, resulting in an increase in relative crystallinity from 11% to 36%. Notably, the crystallization rate of PBT at 0.40 min−1 exceeded that of rPET at 0.36 min−1. PBT minimally affected the crystallization rate constant of rPET‐dominant blends, while rPET significantly reduced the crystallization rate in PBT‐dominant blends.
Properties of polylactic acid blends with potato thermoplastic starch using maleated polyethylene as a compatibilizer
Authors: Licea‐Saucedo Daniel C. , Guzmán‐Rojas Víctor Miguel , Moscoso‐Sánchez Francisco Javier , Rodrigue Denis , González‐Núñez Rubén 
Published: February 2024

AbstractIn this study, blends of polylactic acid (PLA) and potato thermoplastic starch (TPS) with and without maleated polyethylene (MAPE) as a compatibilizer were prepared by twin‐screw extrusion followed by compression molding. Different formulations were proposed based on an experimental design to determine the concentration of each component for a specific range of composition: 49%–79% of PLA, 20%–50% of TPS, and 0.5%–2% of MAPE. As a first step, the mechanical properties (tensile, flexural, and impact) were used to determine the best performance of these formulations. Then, the mechanical results were used in an objective function to maximize the blends' properties compared to virgin PLA. The optimal formulation was found to be 67.5% PLA, 32.0% TPS, and 0.5% MAPE. Selected formulations were characterized for their thermal, morphological, and water absorption properties. The results show the possibility of producing sustainable polymers for single‐use applications.
A roadmap to achieving a healthier information ecosystem through GDPR implementation and privacy compliance technologies
Authors: Li Wilson , Xiong Bingqing , Yang Chaofan 
Published: February 2024

AbstractPrivacy protection has become a central issue in information science, with the General Data Protection Regulation (GDPR) significantly impacting information ecosystems. Research gaps persist in understanding the causal relationship between GDPR implementation and websites' proactive changes, such as adopting privacy compliance technologies. This study aims to examine the influence of GDPR implementation on websites' information ecosystems and identify boundary conditions that may affect this relationship. Utilizing domain‐level data from a professional platform tracking website technologies before and after GDPR implementation, which encompasses a comprehensive longitudinal dataset of over 1.2 million websites, our results indicate that GDPR implementation has increased the decision, breadth, depth, and intensity of adopting related technologies. The variance in these adoptions is significantly shaped by the differing levels of institutional impacts experienced by trailblazing versus laggard industries. Our study contributes to the literature by revealing the importance of policy factors in fostering a healthier information ecosystem. We demonstrate the complex nature of the relationship between policy factors and technology adoption, highlighting the need for researchers to consider institutional context and industry‐specific characteristics. We further discuss valuable insights for relevant stakeholders.
Racial and ethnic disparities in the co‐occurrence of intellectual disability and autism: Impact of incorporating measures of adaptive functioning
Authors: Furnier Sarah M. , Gangnon Ronald , Daniels Julie L. , Ellis Weismer Susan , Nadler Cy , Pazol Karen , Reyes Nuri M. , Rosenberg Steven , Rubenstein Eric , Wiggins Lisa D. , Yeargin‐Allsopp Marshalyn , Durkin Maureen S. 
Published: February 2024

AbstractIntellectual disability (ID) commonly co‐occurs in children with autism. Although diagnostic criteria for ID require impairments in both cognitive and adaptive functioning, most population‐based estimates of the frequency of co‐occurring ID in children with autism—including studies of racial and ethnic disparities in co‐occurring autism and ID—base the definition of ID solely on cognitive scores. The goal of this analysis was to examine the effect of including both cognitive and adaptive behavior criteria on estimates of co‐occurring ID in a well‐characterized sample of 2‐ to 5‐year‐old children with autism. Participants included 3264 children with research or community diagnoses of autism enrolled in the population‐based Study to Explore Early Development (SEED) phases 1–3. Based only on Mullen Scales of Early Learning (MSEL) composite cognitive scores, 62.9% (95% confidence interval [CI]: 61.1, 64.7%) of children with autism were estimated to have co‐occurring ID. After incorporating Vineland Adaptive Behavior Scales, Second Edition (VABS‐II) composite or domains criteria, co‐occurring ID estimates were reduced to 38.0% (95% CI: 36.2, 39.8%) and 45.0% (95% CI: 43.1, 46.9%), respectively. The increased odds of meeting ID criteria observed for non‐Hispanic (NH) Black and Hispanic children relative to NH White children when only MSEL criteria were used were substantially reduced, though not eliminated, after incorporating VABS‐II criteria and adjusting for selected socioeconomic variables. This study provides evidence for the importance of considering adaptive behavior as well as socioeconomic disadvantage when describing racial and ethnic disparities in co‐occurring ID in epidemiologic studies of autism.
Box–Behnken experimental design for optimization of chitosan foam materials reinforced with cellulose and zeolite
Authors: Kurt Rıfat , Ergun Halime , Ergun Mehmet Emin , Istek Abdullah 
Published: February 2024

AbstractFoam materials produced from biopolymers stand out as a more environmentally friendly insulation material solution. This study presents a comprehensive investigation into the development and optimization of chitosan‐based foam materials using a Box–Behnken design. The foams were engineered using varying proportions of chitosan (0.5–3%), cellulose (0.5–3%), and zeolite (0.5–3%), targeting their application as thermal insulators. The physical and thermal properties of the foams that were produced were affected by the type and ratios of components, with density and thermal conductivity ranging from 0.0853 to 0.1915 g cm−3 and 0.0324 to 0.0921 W mK−1, respectively. Higher chitosan content improved insulation properties and mechanical strength whereas zeolite increments increased density and thermal conductivity. Using statistical analysis through the Box–Behnken design, we optimized the foam formulations, achieving minimum thermal conductivity and maximum compression strength at an averaged density, suggesting a strong potential for environmental sustainability applications. The recommended optimal chitosan:cellulose:zeolite composition ratio of 3:3:0.88 provides a valuable insight for tailored foam material formulation. This study shows the relationships between the composition of a composite material and its resultant properties, optimizing its preparation for industrial applicability in an environmentally conscious way within the context of insulation and construction. This investigation contributes to the field of material science by highlighting the versatility and potential of biopolymers but also aligns with the increasing need for green building materials.
Total synthesis of cypripedin
Authors: Kim Hyun Jung , Kang Bok Yun , Shim Jung‐Hyun , Cho Seung‐Sik , Kim Eunae , Yoon Goo 
Published: February 2024

AbstractThe first facile synthesis of cypripedin (1) was achieved using commercially available 2,3‐dihydroxybenzaldehyde (2) and 5‐bromovanillin (4) via a convergent strategy involving the Mizoroki–Heck reaction and photocyclization as key steps.
Corporate sustainability strategy: From definitional ambiguity toward conceptual clarification
Authors: Adolph Jennifer , Beckmann Markus 
Published: February 2024

AbstractThe concept of corporate sustainability strategy (CSS) suffers from considerable definitional ambiguity. Rather than attempting to create a universally acceptable CSS definition, this study scrutinizes the various uses of different existing definitions. Our two‐step methodology began with a systematic literature review to identify different topical perspectives on CSS. Next, a purposeful sampling approach allowed for a more detailed review of each perspective. As a result, we identified and discussed eight topical perspectives: means‐and‐ends, hierarchical, materiality, geographic‐scope, management‐approach, maturity, actor‐and‐process, and contingency perspectives. These were then compared and integrated into a shared conceptual CSS framework. We found the means‐and‐ends perspective to be most fundamental, as it frames how sustainability shapes the purpose and constraints of strategizing. We refine this perspective by distinguishing among indifferent, instrumental, intrinsic, and integrated CSSs. We conclude with discussions on limitations, suggestions for future research, and managerial implications.
Discovery of a Pimaradiene that Decreases Viability of MDA‐MB‐468 Cells Through Inhibition of EGFR Signaling Pathway
Authors: Wang Nina , Qin Li , Liu Zi , Cao Jianguo , Huang Jiayi , Ma Liang , Huang Guozheng 
Published: February 2024

AbstractTriple‐negative breast cancer (TNBC) is characterized by strong invasiveness, high relapse rates, and poor overall survival. It occurs in approximately 15–20 % of all breast cancer cases. Natural compounds are a promising option for managing breast cancer. ent‐8(14),15‐Pimaradiene‐2β,19‐diol (JXE‐23), is a pimaradiene isolated from the fern Aleuritopteris albofusca. However, the effects and molecular mechanisms of JXE‐23 on cancer cells are still unknown. Thus, this study was designed to determine the potential of JXE‐23 for its anticancer properties in TNBC cells. JXE‐23 was evaluated for its antiproliferative activity in vitro against human breast cancer cell lines, and showed selectively cytotoxic activity against MDA‐MB‐468, an EGFR‐overexpressing TNBC cancer cell line, with an IC50 value of 1.17±0.04 μM. Moreover, mechanistic investigations indicated that JXE‐23 was significantly capable of inhibiting cell proliferation and viability in MDA‐MB‐468 cells. In addition, JXE‐23 exerted an anticancer effect against MDA‐MB‐468 cells via restraining cell migration in a dose‐dependent mode. Moreover, after treatment with JXE‐23, the protein expressions of pEGFR, pERK, pAkt and p‐p70S6K were significantly reduced in MDA‐MB‐468 cells. The results underscored that JXE‐23 could be a potential lead compound for the treatment of EGFR‐overexpressing TNBC cells.
Long term clinical outcome of sirolimus drug coated balloons in large coronary vessels
Authors: Sciahbasi Alessandro , Salvi Nicolò , Heang Tay M. , Perez Ignacio S. , Geraci Salvatore , Vaccaro Giovanni , Benincasa Susanna , Nuruddin Amin A. , Ocaranza Raymundo , Giannini Francesco , Greco Antonio , Cortese Bernardo 
Published: February 2024

AbstractBackgroundStudies evaluating the safety and efficacy of drug coating balloons (DCB) for the treatment of lesions in large coronary vessel are limited.AimsOur study aimed to evaluate the performance of a sirolimus DCB in large coronary arteries.MethodsWe analyzed all the procedures included in the EASTBOURNE Registry (NCT03085823) enrolling patients with a clinical indication to percutaneous coronary intervention performed by a sirolimus DCB according to investigator judgment. In the present analysis, a cut‐off of 2.75 mm was used to define large coronary arteries. Primary endpoint of the study was clinically driven target lesion revascularization (TLR) at 24 months whereas secondary endpoint included procedural success, myocardial infarction (MI), cardiac death and total mortality.ResultsAmong the 2123 patients and 2440 lesions enrolled in the EASTBOURNE study between 2016 and 2020, 757 patients/810 lesions fulfilled the criteria for the present analysis. Mean reference vessel diameter was 3.2 ± 0.3 mm with mean lesion length of 22 ± 7 mm. Procedural success was high (96%) and at 2‐year follow up the device showed a good efficacy with a TLR rate of 9%. There were 34 deaths (4.5%), 30 MIs (4%) and 8 BARC type 3–5 bleedings (1.1%). In‐stent restenosis (629 lesions) and de novo lesions (181) were associated with 11% and 4% rates of TLR at 2 years, respectively (p = 0.003).ConclusionsClinical performance of a sirolimus DCB in large coronary artery vessels shows promising signals at 2‐year follow up, both in de novo and in‐stent restenosis lesions.
Ultrasound‐assisted endovascular thrombolysis versus large‐bore thrombectomy in acute intermediate‐high risk pulmonary embolism: The propensity‐matched EKNARI cohort study
Authors: Al‐Terki Hani , Lauder Lucas , Mügge Andreas , Götzinger Felix , Elhakim Abdelrahman , Mahfoud Felix 
Published: February 2024

AbstractBackgroundUltrasound‐assisted thrombolysis (USAT) and large‐bore‐thrombectomy (LBT) are under investigation for the treatment of intermediate‐high and high‐risk pulmonary embolisms (PE). Comparative studies investigating both devices are scarce.AimsThis study aimed to compare the safety and efficacy of the two most frequently used devices for treatment of acute PE.MethodsThis multicenter, retrospective study included 125 patients undergoing LBT or USAT for intermediate‐ or high‐risk PE between 2019 and 2023. Nearest neighbor propensity matching with logistic regression was used to achieve balance on potential confounders. The primary outcome was the change in the right to left ventricular (RV/LV) ratio between baseline and 24 h.ResultsA total of 125 patients were included. After propensity score matching, 95 patients remained in the sample, of which 69 (73%) underwent USAT and 26 (27%) LBT. The RV/LV ratio decrease between baseline and 24 h was greater in the LBT than in the USAT group (adjusted between‐group difference: −0.10, 95% CI: −0.16 to −0.04; p = 0.001). Both procedures were safe and adverse events occurred rarely (10% following USAT vs. 4% following LBT; p = 0.439).ConclusionIn acute intermediate‐high and high‐risk PE, both LBT and USAT were feasible and safe. The reduction in RV/LV ratio was greater following LBT than USAT. Further randomized controlled trials are needed to confirm these findings.
Prognostic impact of main pulmonary artery to ascending aorta diameter ratio in patients with severe aortic stenosis underwent transcatheter aortic valve implantation
Authors: Hakgor Aykun , Dursun Atakan , Kahraman Basak Catalbas , Yazar Arzu , Savur Umeyir , Akhundova Aysel , Olgun Fatih Erkam , Arman Mehmet Emir , Boztosun Bilal 
Published: February 2024

AbstractBackgroundPulmonary hypertension (PH) and right ventricular dysfunction are poor prognostic predictors in patients underwent transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS).AimsThe prognostic impact of the main pulmonary artery/ascending aorta diameter ratio (MPA/AOr), measured simply by computed‐tomographic angiography (CTA), was investigated in this patient group.MethodsA total of 374 retrospectively evaluated patients (mean age 78.1 ± 8.4 years, 192 [51.3%] females) who underwent TAVI for severe AS were included. MPA/AOr was measured on preprocedural CTA in all patients and the effect of this measurement on the presence of PH, in‐hospital and 2‐year‐overall long‐term mortality was investigated.ResultsThe presence of PH was defined as a systolic pulmonary artery pressure (sPAP) >42 mmHg measured by echocardiography. According to multivariate‐logistic‐regression analysis, MPA/AOr (adjusted [Adj] odds ratio [OR]: 1.188, confidence interval [CI] 95% [1.002–1.410], p = 0.048), tricuspid annular plane systolic excursion (TAPSE) (adj OR:0.736, CI 95% [0.663–0.816], p < 0.001) and left atrial diameter (adj OR:1.051, CI 95% [1.007–1.098], p = 0.024) were identified as independent predictors of PH. In addition, a statistically significant correlation was found between MPA/AOr and TAPSE (r: −0.283, p < 0.001). Furthermore, MPA/AOr was found to be an independent predictor of both in‐hospital (adj OR:1.434, CI 95% [1.093–1.881], p = 0.009) and 2‐year long‐term (adj OR:1.518, CI 95% [1.243–1.853], p < 0.001) mortality in multivariate analysis including TAPSE, STS score and sPAP. In the 2‐year Kaplan–Meier survival probability analysis, an MPA/AOr >0.86 was found to have a hazard ratio of 3.697 (95% CI: 2.341–5.840), with a log‐rank p < 0.001.ConclusionMPA/AOr, which can be measured simply by CTA, may be useful as an indicator of the presence of PH and poor prognosis in patients planned for TAVI for severe AS.
Appropriate dose of NaCl supplementation improves protein structures, microbial communities and extensibility of dough, and quality of traditional fermented dried noodles
Authors: Tang Renyong , Fan Chengmeng , Liu Sunpeng , Zhang Beibei , Gong Yuhui , Guo Xiulan 
Published: February 2024

AbstractBackground and ObjectivesIn the production process of Zhongjiang traditional fermented dried noodles (TFDNs), about 10% of NaCl is added; however, the underlying mechanisms of its effects remain unclear. Thus, this study aimed to investigate the impact of varying NaCl concentrations (6%–14%) on protein conformation, tensile and rheological properties, microbial communities in the dough, and quality of the dried noodles.FindingsThe results indicated that 6%–10% NaCl supplementation increased the ordered structures, disulfide bond contents, rheological parameters, the abundance of Pantoea and cumulative abundance of Mitochondria and Chloroplast in the dough, and reduced bacterial diversity and disordered structures; 8%–10% NaCl enhanced tensile properties of dough, cooking quality, and sensory attributes of noodles; cooked noodles with 10% NaCl had the best hardness, adhesiveness, springiness, and chewiness. However, excessive NaCl (12%–14%) did not confer these benefits. Furthermore, dough containing 6% NaCl exhibited excessive stickiness and reduced tensibility, rendering it unsuitable for making dried noodles.ConclusionsThe addition of 8%–10% NaCl improved protein structural properties and bacterial community in the dough and ultimately elevated the extensibility of the dough and the quality of TFDN.Significance and NoveltyThese findings reveal the potential mechanisms of NaCl in the processing of TFDN and lay a foundation for producing healthier TFDN with lower sodium in the future.
Polyoxometalate‐Based Frameworks: Construction Strategies and Photocatalytic Applications
Authors: Yang Lu , Xu Mengzhen , Wang Haining , Zhang Daopeng , Zhou Zhen 
Published: February 2024

AbstractPolyoxometalate‐based frameworks, as a kind of material constructed by polyoxometalates (POMs), metal ions or clusters, organic ligands, are combined both the advantages of oxygen‐rich POMs and porous metal‐organic frameworks (MOFs) within one single system. This integration greatly expands their potential applications compared to the individual POMs or MOFs. Particularly for photocatalysis, the narrow light absorption range of the typical POMs units in the ultraviolet region hinders their extensive uses as visible‐light‐driven photocatalysts. However, the incorporation of photoactive units into POMs‐based frameworks can be considered as an effective approach to overcome this limitation. In this paper, we review selected examples of recent progress based on the POM‐based frameworks along with their construction strategies and applications in various areas of photocatalysis, mainly including water splitting, CO2 reduction, organic synthesis and also the selective coupling reactions.