bluuebunny/crossref_metadata_2025_split huggingface dataset:
The critical roles of three sugar-related proteins (HXK, SnRK1, TOR) in regulating plant growth and stress responses
Authors: Li Guangshuo , Zhao Ying 
Published: April 2024

Abstract
Sugar signaling is one of the most critical regulatory signals in plants, and its metabolic network contains multiple regulatory factors. Sugar signal molecules regulate cellular activities and organism development by combining with other intrinsic regulatory factors and environmental inputs. HXK, SnRK1, and TOR are three fundamental proteins that have a pivotal role in the metabolism of sugars in plants. HXK, being the initial glucose sensor discovered in plants, is renowned for its multifaceted characteristics. Recent investigations have unveiled that HXK additionally assumes a significant role in plant hormonal signaling and abiotic stress. SnRK1 serves as a vital regulator of growth under energy-depleted circumstances, whereas TOR, a large protein, acts as a central integrator of signaling pathways that govern cell metabolism, organ development, and transcriptome reprogramming in response to diverse stimuli. Together, these two proteins work to sense upstream signals and modulate downstream signals to regulate cell growth and proliferation. In recent years, there has been an increasing amount of research on these three proteins, particularly on TOR and SnRK1. Furthermore, studies have found that these three proteins not only regulate sugar signaling but also exhibit certain signal crosstalk in regulating plant growth and development. This review provides a comprehensive overview and summary of the basic functions and regulatory networks of these three proteins. It aims to serve as a reference for further exploration of the interactions between these three proteins and their involvement in co-regulatory networks.
Conditioning of random Fourier feature matrices: double descent and generalization error
Authors: Chen Zhijun , Schaeffer Hayden 
Published: April 2024

Abstract
We provide high-probability bounds on the condition number of random feature matrices. In particular, we show that if the complexity ratio $N/m$, where $N$ is the number of neurons and $m$ is the number of data samples, scales like $\log ^{-1}(N)$ or $\log (m)$, then the random feature matrix is well-conditioned. This result holds without the need of regularization and relies on establishing various concentration bounds between dependent components of the random feature matrix. Additionally, we derive bounds on the restricted isometry constant of the random feature matrix. We also derive an upper bound for the risk associated with regression problems using a random feature matrix. This upper bound exhibits the double descent phenomenon and indicates that this is an effect of the double descent behaviour of the condition number. The risk bounds include the underparameterized setting using the least squares problem and the overparameterized setting where using either the minimum norm interpolation problem or a sparse regression problem. For the noiseless least squares or sparse regression cases, we show that the risk decreases as $m$ and $N$ increase. The risk bound matches the optimal scaling in the literature and the constants in our results are explicit and independent of the dimension of the data.
Using the response–effect trait framework to disentangle the effects of environmental change on the ecosystem services
Authors: Zheng Cheng , Zhang Fei , Lin Ziqi , Yuan Liuhuan , Yao Hongbin , Duan Gaohui , Liu Yandan , Liu Yangyang , Shi Haijing , Wen Zhongming 
Published: April 2024

Abstract
Functional traits play a vital role in mediating the responses of ecosystem services to environmental changes and in predicting the functioning of the ecosystem. However, the connection between functional traits and ecosystem services has become increasingly intricate due to climate change and human activities for degraded ecosystems. To investigate this relationship, we selected 27 sampling sites in the Yanhe River Basin of the Chinese Loess Plateau, each containing two types of vegetation ecosystems: natural vegetation and artificial vegetation ecosystems. At each sampling site, we measured ecosystem services and calculated the composition index of community traits. We established a response–effect trait framework that included environmental factors such as climate, elevation and human activities. Our results showed that leaf tissue density (LTD) was the overlapping response and effect trait when responding to climate change. LTD is positively correlated with mean annual temperature and negatively correlated with supporting services. Under the influence of human activities, leaf nitrogen content and leaf dry matter content were carriers of environmental change. Comparing the two vegetation ecosystems, the relationship between functional traits and ecosystem services showed divergent patterns, indicating that human activities increased the uncertainty of the relationship between functional traits and ecosystem services. Trait-based ecology holds promise for enhancing predictions of ecosystem services responses to environmental changes. However, the predictive ability is influenced by the complexity of environmental changes. In conclusion, our study highlights the importance of understanding the complex connection between functional traits and ecosystem services in response to climate changes and human activities.
Relaparotomy pseudoaneurysm repair after distal pancreatectomy with celiac axis resection (DP-CAR): a case report
Authors: Nakamura Shun , Tada Kazuhiro , Mita Junya , Fukuzawa Kengo 
Published: April 2024

Abstract
A 76-year-old man underwent distal pancreatectomy with celiac axis resection (DP-CAR) after preoperative chemotherapy for pancreatic cancer with celiac artery invasion. Although postoperative pancreatic leakage and ischemia-induced bile fistula developed, the patient’s condition remained stable with good drainage. On postoperative Day 47, a pseudoaneurysm developed at the junction of the gastroduodenal artery and proper hepatic artery. However, cannulation of the guidewire was difficult, and relaparotomy pseudoaneurysm repair was performed. On postoperative Day 56, a pseudoaneurysm reappeared at the same site, and relaparotomy was performed again. On postoperative Day 61, CT confirmed the disappearance of the pseudoaneurysm and preservation of the right and left hepatic arteries. The patient was discharged 107 days postoperatively. Interventional radiology (IVR) remains the best technique to achieve hemostasis for pseudoaneurysms. However, this case demonstrates that even when hemostasis by IVR is difficult, relaparotomy pseudoaneurysm repair after DP-CAR may be useful after some postoperative.
Auditory-Motor Mapping Training With an Autistic Child from a Bilingual Family
Authors: Kim Hae Sun 
Published: April 2024

Abstract
Bilingual immigrant family members in the United States may experience specific challenges in providing support to their autistic children, who often exhibit speech delays and communication issues. These challenges can arise from a combination of language barriers, cultural obstacles, and a lack of therapeutic resources in their heritage language; a term synonymous with “home language,” “native language,” and “mother tongue,” referring to a language other than English used by immigrants and their children.
This article focuses on addressing these issues through an adaptation of auditory-motor mapping training (AMMT), a specific therapeutic intervention originally designed for autistic children who consider English as their primary language, aiming to enhance speech production. This article brings forward a case example of an autistic child of a Korean immigrant family to illustrate the adaptation process of AMMT from English to another language, Korean, specifically the Seoul dialect. This study highlights three factors music therapists should consider during the adaptation: (a) phonological distinctions between the heritage language and English; (b) the language spoken within the child’s home and the parents’ perspective on bilingualism; and (c) the unique attributes of each autistic child. The pros and cons of AMMT and recommendations for music therapy professionals are also discussed.
Proactive policing and traffic disturbances: A quasi-experiment in three Israeli cities
Authors: Hasisi Badi , Weisburd David , Litmanovitz Yael , Carmel Tomer , Tshuva Shani , Trahtenberg Taina 
Published: April 2024

Abstract
This paper describes a quasi-experimental evaluation of a reform in Israel (‘EMUN’), which attempted to institutionalize problem-oriented policing on a national scale. The current study examines the effect of this reform on tackling traffic disturbance and road bullying offences. We compared three police stations that chose to deal with traffic offences using the tools and techniques provided through the reform (treatment stations) with five police stations that were matched - using a specially designed algorithm - on several criteria, including similar trends of traffic offences (comparison stations). Each treatment station was compared to two comparison stations using a difference-in-differences approach. In five out of six comparisons there were large and significant reductions in documented traffic disturbances in the targeted areas of the treatment stations compared to the control stations. We also found evidence of significant diffusions in crime control benefits in two of the treatment stations. However, there was evidence of significant geographical displacement to the buffer zone in the largest treatment stations. We attribute this to differences in the nature of the areas targeted and discuss the relative harms and benefits. The findings of the study show that institutionalizing a variety of evidence-based policing strategies has a promise not only for classic crimes (such as property and violence), but also for incivilities and quality-of-life offenses.
Effects of a work schedule with abated quick returns on insomnia, sleepiness, and work-related fatigue: results from a large-scale cluster randomized controlled trial
Authors: Djupedal Ingebjørg Louise Rockwell , Harris Anette , Svensen Erling , Pallesen Ståle , Waage Siri , Nielsen Morten Birkeland , Sunde Erlend , Bjorvatn Bjørn , Holmelid Øystein , Vedaa Øystein 
Published: April 2024

Abstract

Study objectives
To investigate the effect of a work schedule with abated quick returns (i.e. &gt; 11 hours between two shifts) on insomnia, daytime sleepiness, and work-related fatigue compared to a shift schedule maintaining the usual number of quick returns.

Methods
A two-armed cluster randomized controlled trial including 66 units was conducted at a university hospital in Norway. Units with healthcare workers on rotating shift schedules were randomly assigned to a shift schedule with abated quick returns (intervention) or to continue with a schedule including quick returns as usual (control) for 6 months. Questionnaires assessed symptoms of insomnia (Bergen Insomnia Scale [BIS]), daytime sleepiness (Epworth Sleepiness Scale [ESS]), and work-related fatigue (Revised Swedish Occupational Fatigue Inventory) at baseline and towards the end of the intervention. Data were analyzed using multilevel linear mixed-effects models, and Cohen’s d was used to calculate the effect size between groups.

Results
Overall, 1314 healthcare workers (85.2% female) completed the baseline questionnaire (response rate 49.1%), and 552 completed the follow-up questionnaire. The intervention reduced quick returns from an average of 13.2 (SD = 8.7) to 6.7 (SD = 6.0), while the control group’s average remained relatively unchanged from 13.2 (SD = 8.7) to 12.0 (SD = 9.3). Results showed a small improvement in symptoms of insomnia (BIS; d = −0.13, p = .022) and daytime sleepiness (ESS; d = −0.14, p = .013) in favor of the intervention. No effects were observed on work-related fatigue.

Conclusions
Reducing the number of quick returns in the work schedule resulted in improvements in insomnia and daytime sleepiness. The findings highlight the importance of sufficient daily rest time in the work schedule of healthcare workers.

Clinical Trial
Health Promoting Work Schedules: The Effect of Abolishing Quick Returns (HeWoS); clinicaltrials.gov/ct2/show/NCT04693182; Registered at ClinicalTrials.gov with the identifier NCT04693182.
Long-Term Outcome Following Treatment With Allogeneic Mesenchymal Stem/Stromal Cells for Radiation-Induced Hyposalivation and Xerostomia
Authors: Jakobsen Kathrine Kronberg , Lynggaard Charlotte Duch , Paaske Natasja , Carlander Amanda-Louise Fenger , Kastrup Jens , Hauge Anne Werner , Christensen Robin , Grønhøj Christian , Buchwald Christian von 
Published: April 2024

Abstract

Background
Adipose-derived mesenchymal stem/stromal cells (ASCs) are proposed as a new xerostomia treatment. The study evaluated the long-term safety and effectiveness of allogeneic ASCs in radiation-induced xerostomia among patients with previous oropharyngeal cancer.

Methods
This study constitutes 3-year follow-up on the original 10 patients who received allogeneic ASCs injections to the submandibular and parotid glands as part of the MESRIX-II trial. The MESRIX-II trial included the preliminary 4-month follow-up. The primary endpoint was long-term safety. Secondary endpoints were effectiveness evaluated by changes in salivary flow rate and patient-reported outcomes (PROs). Immune response was evaluated by assessing the development of donor-specific antibodies (DSA).

Findings
All 10 MESRIX-II patients completed the long-term follow-up (ie, no missing data). During the long-term follow-up, 2 patients encountered a significant adverse event, which was determined to be unrelated to the treatment. No DSAs were detectable at 3 years. The stimulated salivary flow rate increased significantly from an average of 0.66 mL/minute at baseline to 0.86 mL/minute at follow-up, corresponding to an increase of 0.20 [95% CI 0.08 to 0.30] mL/minute, or approximately 30%. Among the PROs, sticky saliva symptoms were reduced, with a −20.0 [95% CI −37.3 to −2.7] units.

Interpretation
In conclusion, this study is the first to present long-term follow-up outcomes of allogeneic ASC treatment as a therapeutic option for radiation-induced xerostomia. The study found that ASC treatment appears safe, and there were no indications of adverse immune responses at the 3-year follow-up. Further studies are warranted to evaluate the findings in larger settings.
A Concept Analysis of Paternal Bonding With Prematurely Born Infants
Authors: Alnuaimi Nisreen , Snedden Traci 
Published: April 2024

Background:
Maternal bonding in infancy has long been the focus of research and practice. Despite emerging evidence highlighting the importance of paternal bonding, little attention has been focused on fathers. Simultaneously, there is little clarity regarding possible differences between bonding and attachment.

Purpose:
This article aims to clarify the concept of paternal bonding with infants born prematurely.

Methods/Search Strategy:
Using Walker and Avant’s approach to concept analysis, we selected databases and searched them for relevant studies published between 2012 and 2022. We identified 28 articles that (1) defined bonding specific to fathers of infants born prematurely, (2) were peer-reviewed, and (3) were in English. From the articles, we extracted and analyzed data specific to concept definitions, antecedents, and consequences.

Results:
Regarding paternal bonding with infants born prematurely, our analyses of the 28 studies yielded a conceptual definition of this topic that extends beyond the commonly used definition emphasizing emotional connection. The newly formulated definition covers the cognitive, behavioral, and dynamic, as well as emotional, attributes of bonding. We identify and discuss antecedents and consequences of bonding.

Implications for Practice and Research:
Our findings led to a consistent conceptual definition of the bonding phenomenon in question. The definition should serve as a conceptual basis for future guidelines governing clinical practice and research. Through our findings, nurses can better understand and promote paternal bonding with infants born prematurely. Finally, our findings can improve researchers’ exploration of this topic.
Matrix Metalloproteinase-9 in the Etiopathogenesis of Placenta Accreta Spectrum: A Literature Review
Authors: Mirani Putri , Lestari Peby Maulina , Murti Krisna , Liberty Iche Andriyani , Andrina Hana , Kesty Cindy , Stevanny Bella 
Published: April 2024

Abstract
The recent increase in placenta accreta spectrum has been correlated with a rise in the rate of cesarean sections. A recent study provides evidence that hampered wound healing results in cesarean scar defects that lead to a failure in the normal process of decidualization and deeper adherence of trophoblasts. Matrix metalloproteinase (MMP) is crucial in every step of wound healing as it alters the wound matrix, facilitating cell migration, as well as tissue remodeling. MMP-9 expression is higher in placental and decidual tissue in cases of placenta accreta. Based on these findings, assessment of MMP-9 expression can shed new light on the etiopathology of placenta accreta spectrum disorder and can be a potential diagnostic marker.
In-and-out Technique: An In-house Efficient Predictive Hole Fabrication Workflow
Authors: Asensio-Salazar Javier , Rivero Calle Alvaro , Olavarría Montes Eduardo , Delgado Fernández Alejandro , Zubillaga Rodríguez Ignacio , Gutiérrez Díaz Ramon , Sánchez Aniceto Gregorio 
Published: April 2024

Summary:
Virtual surgical planning (VSP) and three-dimensional (3D) printing can increase precision and reduce surgical time in craniofacial reconstruction. However, the elevated cost and manufacturing time of outsourced workflows is increasing the development of in-house solutions. One of the main challenges in in-house workflows is to create cutting guides that hold plate position information. This is due to the fact that hospitals usually lack the infrastructure required to design and 3D print custom-made plates. Including plate-positioning information in resection guides is especially relevant in complex reconstructions and when tumor extension limits plate placement before resection. Current in-house workflows revolve around the idea of 3D scanning the bent plate’s shape and to fuse it with the VSP. The goal of this article is to share our technique to transfer plate position information to resection guides. Our protocol uses a 3D model of the reconstruction as an intermediate step to transfer the plate position of a bent stock reconstruction plate to cutting guides. Two patients who required mandibular reconstruction with fibula flap are presented to illustrate the technique. This workflow requires a 3D-printed model of the desired outcome, cutting guides, and a stock plate. Results were satisfactory in terms of cutting location and angulation, plate adaptation and condylar position. This technique allows for a simple, safe, cheap, and quick alternative to add reconstruction plate information to cutting guides.
Effects of Sociodemographic and Child Opportunity Index on Pediatric Plastic and Oral and Maxillofacial Surgical Volume Trends in the COVID-19 Pandemic
Authors: McCollister Kali , Berry Jay G. , Melvin Patrice , Tartarilla Ashley B. , Nuzzi Laura C. , Lajoie Debra , Meara John G. , Ward Valerie L. 
Published: April 2024

Background:
The coronavirus disease 2019 (COVID-19) pandemic caused disruptions to pediatric surgical care. Although surgical capacity has returned to the prepandemic state, barriers to surgical access may still exist for children who are medically underserved. We assessed pediatric plastic and oral and maxillofacial surgical volumes by sociodemographic characteristics before and during the COVID-19 pandemic.

Methods:
A 72-month retrospective cohort analysis of 10,681 pediatric plastic and oral and maxillofacial procedures between 2016 and 2021 was conducted. Multivariable logistic regression and interrupted time series analyses were used to analyze surgical volume trends by sociodemographic groups and Child Opportunity Index (COI).

Results:
Compared with prepandemic, patients undergoing procedures were more likely to be older than 18 years (P < 0.001) and Hispanic/Latino (adjusted odds ratio 1.38; 95% confidence interval, 1.14–1.68; P < 0.01). Surgical volume trends among patients from the lowest COI levels were lower than where they were estimated to have been if the pandemic did not occur (P = 0.040). Patients who spoke a primary language other than English or Spanish (P = 0.02) and patients with the lowest COI levels (P = 0.04) continued to have unrecovered surgical volumes.

Conclusions:
There were differences in the sociodemographic case-mix of patients undergoing plastic and oral and maxillofacial surgical procedures before and during the pandemic, and surgical volumes did not recover at the same rate for all patients. Further research can determine why certain sociodemographic groups and patients with low COI levels had decreased surgical access compared with prepandemic trends, and develop interventions focused on equitable pediatric surgical access.
Sushruta: The Father of Indian Surgical History
Authors: Dave Tirth , Habte Alexander , Vora Vidhi , Sheikh Mahin Qudeer , Sanker Vivek , Gopal Sri Vengadesh 
Published: April 2024

Summary:
Sushruta, an ancient surgeon from 600 BCE in Kashi, India, is a pioneering figure in medical history. His innovations in surgical techniques, predating Hippocrates and Galen, have left an indelible mark in the field. This review article focuses on Sushruta’s contributions to surgery, particularly his foundational work in plastic and reconstructive procedures. We delve into the Sushruta Samhita, the oldest surgical text, covering essential principles, pathology, anatomy, and surgical management. Sushruta’s approach emphasized cleanliness, cadaver dissection, and innovative practices in anesthesia. Our article underscores the enduring impact of Sushruta’s work on modern surgical science.
A case report of multiple endocrine neoplasia type 2B
Authors: Jahantab Mohammad Bagher , Rastegar Babak , Aria Arash 
Published: April 2024

Introduction and importance:
Multiple Endocrine Neoplasia Type 2 (MEN2) is a rare autosomal dominant neoplastic syndrome resulting from RET gene mutations, marked by medullary thyroid carcinoma (MTC) and increased risk of other endocrine tumors. MEN2 includes subtypes MEN2A, MEN2B, and familial MTC. Prophylactic thyroidectomy is recommended for MEN2A due to high MTC risk.

Case presentation:
A 38-year-old woman with a family history of thyroid cancer presented with headaches, sweating, and palpable breast mass. Exam revealed skin lesions. Lab abnormalities and imaging indicated a large adrenal mass and thyroid nodules. Inconclusive biopsies led to left adrenalectomy, confirming pheochromocytoma. Subsequent total thyroidectomy revealed MTC.

Clinical discussion:
This case represents rare MEN2B presentation, featuring MTC, pheochromocytoma, mucosal neuromas, and marfanoid habitus. Genetic testing for RET mutations is crucial with a positive family history. MEN2A individuals undergo prophylactic thyroidectomy due to high MTC risk. Although rare, pheochromocytoma can be an initial MEN2 manifestation, indicated by paroxysmal symptoms. Surgical resection is the treatment.

Conclusions:
The patient’s successful adrenalectomy followed by total thyroidectomy confirmed MTC. Thorough evaluation, including inconclusive initial findings, emphasizes imaging, and biopsies. Early detection and appropriate management optimize MEN2 outcomes.