bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compounds based on Adamantyl-substituted Amino Acids and Peptides as Potential
Antiviral Drugs Acting as Viroporin Inhibitors
Authors: Garaev Timur M. , Grebennikova Tatyana V. , Lebedeva Varvara V. , Avdeeva Varvara V. , Larichev Viktor F. 
Published: March 2024

Abstract:
The discussion has revolved around the derivatives of amino acids and peptides containing carbocycles
and their potential antiviral activity in vitro against influenza A, hepatitis C viruses, and coronavirus.
Studies conducted on cell cultures reveal that aminoadamantane amino acid derivatives exhibit the capacity to
hinder the replication of viruses containing viroporins. Furthermore, certain compounds demonstrate potent
virucidal activity with respect to influenza A/H5N1 and hepatitis C virus particles. A conceptual framework
for viroporin inhibitors has been introduced, incorporating carbocyclic motifs as membranotropic carriers in
the structure, alongside a functional segment comprised of amino acids and peptides. These components correspond
to the interaction with the inner surface of the channel's pore or another target protein.
Network Pharmacology along with Molecular Docking to Explore the Mechanism of
Danshen Injection against Anthracycline-induced Cardiotoxicity and Transcriptome
Validation
Authors: Dai Quankai , Pan Yijun , Zhu Xiwen , Chen Mengyao , Xie Lin , Zhu Yu , Wan Guoxing 
Published: March 2024

Introduction:
Although anthracyclines have demonstrated efficacy in cancer therapy, their utilization
is constrained by cardiotoxicity. In contrast, Danshen injection (DSI), derived from Salvia miltiorrhiza,
has a longstanding tradition of being employed to ameliorate cardiovascular ailments, including anthracycline-
induced cardiotoxicity (AIC). Nonetheless, there is a notable dearth of comprehensive systematic investigation
into the molecular mechanisms underlying DSI's effects on AIC. Consequently, this study was undertaken
to explore the underlying mechanism by which DSI acted against AIC.

Methods:
Employing network pharmacology approach, the current investigation undertook a comprehensive
analysis of the impact of DSI on AIC, which was further validated by transcriptome sequencing with in vitro
AIC model. Additionally, molecular docking was conducted to evaluate the binding of active ingredients to
core targets. A total of 3,404 AIC-related targets and 12 active ingredients in DSI, including chrysophanol,
luteolin, tanshinone IIA, isoimperatorin, among others, were collected by differentially expressed analysis and
database search, respectively.

Results:
The network pharmacology and enrichment analysis suggested 102 potential targets and 29 signaling
pathways associated with the protective effect of DSI on AIC. Three core targets (CA12, NOS3, and POLH)
and calcium signaling pathways were further validated by transcriptomic analysis of the in-vitro model. The
high affinity of the active ingredients binding to corresponding targets was confirmed by molecular docking.

Conclusion:
The present study suggested that DSI might exert a cardioprotective effect on AIC via the inhibition
of CA12, NOS3, and POLH, as well as the modulation of calcium signaling. Further experiments are
warranted to verify the findings.
Specific Targeting of Zinc Transporter LIV-1 with Immunocytokine
Containing Anti-LIV-1 VHH and Human IL-2 and Evaluation of its In vitro
Antitumor Activity
Authors: Dehghan Rada , Parikhani Arezoo Beig , Cohan Reza Ahangari , Shokrgozar Mohammad Ali , Mirabzadeh Esmat , Ajdary Soheila , Zeinali Sirous , Ghaderi Hajarossadat , Talebkhan Yeganeh , Behdani Mahdi 
Published: March 2024

Background:
Interleukin 2 (IL-2) is a vital cytokine in the induction of T and NK cell responses,
the proliferation of CD8+ T cells, and the effective treatment of human cancers, such as melanoma and renal
cell carcinoma. However, widespread use of this cytokine is limited due to its short half-life, severe toxicity,
lack of specific tumor targeting, and activation of Treg cells mediated by high-affinity interleukin-2 receptors.

Objective:
In this study, a tumor-targeting LIV-1 VHH-mutIL2 immunocytokine with reduced CD25 (α chain
of the high-affinity IL-2 receptor) binding activity was developed to improve IL-2 half-life by decreasing its renal infiltration in comparison with wild and mutant IL-2 molecules.

Methods:
The recombinant immunocytokine was designed and expressed. the biological activity of the purified fusion protein was investigated in in vitro and in vivo experiments

Results:
The fusion protein represented specific binding to MCF7 (the breast cancer cell line) and more efficient cytotoxicity than wild-type IL-2 and mutant IL-2. the PK parameters of the recombinant immunocytokine were also improved in comparison to the IL-2 molecules.

Conclusion:
The observed results showed that LIV1-mIL2 immunocytokine could be considered an effective
agent in the LIV-1-targeted treatment of cancers due to its longer half-life and stronger cytotoxicity.
Advancing Breast Cancer Drug Delivery: The Transformative Potential of
Bioinformatics and Artificial Intelligence
Authors: Singh Dilpreet , Sachdeva Diksha , Singh Lovedeep 
Published: March 2024

Abstract:
Breast cancer remains a significant global health challenge, necessitating innovative approaches
to improve treatment efficacy while minimizing side effects. This review explores the promising
advancements in breast cancer drug delivery driven by the transformative potential of bioinformatics
and Artificial Intelligence (AI). Bioinformatics plays a pivotal role in unraveling the intricate
genomic landscape of breast cancer, enabling the identification of potential drug targets and biomarkers.
The integration of multi-omics data facilitates a comprehensive understanding of the disease,
guiding personalized treatment strategies. Moreover, bioinformatics-driven approaches aid in
biomarker discovery and prediction, offering novel tools for prognosis and treatment response assessment.
AI, particularly machine learning and deep learning, has revolutionized breast cancer research.
Machine learning models empower accurate diagnosis through image analysis, improve survival
prediction, and enhance risk assessment. Deep learning algorithms, such as convolutional neural
networks, enable precise tumor detection and classification from medical imaging data, notably
mammograms and MRI scans. Additionally, natural language processing techniques facilitate the
mining of vast scientific literature, uncovering hidden insights and identifying potential drug targets.
Network-based approaches integrated with AI algorithms facilitate the identification of central proteins
as promising drug targets within complex biological networks. This review also examines AIoptimized
nanoformulations designed to enhance targeted drug delivery. AI-guided design of drugloaded
nanoparticles improves drug encapsulation efficiency, release kinetics, and site-specific delivery,
offering promising solutions to overcome the challenges of conventional drug delivery.
Investigating the Effects of Dorema hyrcanum Root Extracts on Selective Induction of
Programmed Cell Death in Glioblastoma, Ovarian Cancer and Breast Cancer Cell
Lines
Authors: Shandi Mahsa Hatami , Sahranavard Shamim , Bagheri Fereshteh , Shahsavari Zahra , Salami Siamak 
Published: March 2024

Background:
Despite remarkable advances, cancer has remained the second cause of death, which
shows that more potent novel compounds should be found. Ethnobotanical compounds have a long history of
treating diseases, and several approved chemotherapeutic compounds were isolated from plants.

Objective:
The research aimed to evaluate the cytotoxic effects of Dorema hyrcanum root extract on ovarian,
breast, and glioblastoma cells while examining its selectivity towards normal cells. Additionally, the study is
directed to investigate cell death mechanisms, delineate modes of cell death, and explore intracellular ROS production.

Methods:
Cytotoxic effects of alcoholic, dichloromethane, and petroleum ether fractions of Dorema hyrcanum
were investigated on cancer and normal cells by using MTT assay, and the concentration around IC50 values was
used for flow cytometric assessment of apoptosis, evaluation of the expression of selected genes via RT-qPCR
and production of ROS.

Results:
Methanolic extract exhibited the highest cytotoxicity, impacting A2780CP and MDA-MB-231. All fractions
showed comparable effects on U251 cells. Notably, extracts displayed higher IC50 values in normal HDF
cells, indicating cancer cell specificity. Flow cytometry revealed induction of apoptosis and non-apoptotic death
in all three cancer cell lines. QPCR results showed upregulation of related genes, with RIP3K prominently increased
in U251 glioblastoma. The DCFH-DA assay demonstrated ROS induction by the PE fraction exclusively
in A2780CP cells after 30 minutes and up to 24 hours.

Conclusion:
Dorema hyrcanum root extracts exhibited potent anti-tumor effects against all studied cell lines. The
methanolic extract demonstrated the highest cytotoxicity, particularly against A2780CP and MDA-MB-231 cells.
Importantly, all fractions displayed selectivity for cancer cells over normal HDF cells. Unique modes of action
were observed, with the petroleum ether fraction inducing significant non-apoptotic cell death. These findings
suggest promising therapeutic potential for Dorema hyrcanum in cancer treatment with subject to further mechanistic
studies.
Cardiac Rehabilitation During the COVID-19 Pandemic and the Potential for Digital Technology to Support Physical Activity Maintenance: Qualitative Study
Authors: Park Linda G , Chi Serena , Pitsenbarger Susan , Johnson Julene K , Shah Amit J , Elnaggar Abdelaziz , von Oppenfeld Julia , Cho Evan , Harzand Arash , Whooley Mary A 
Published: March 2024

Background
Social distancing from the COVID-19 pandemic may have decreased engagement in cardiac rehabilitation (CR) and may have had possible consequences on post-CR exercise maintenance. The increased use of technology as an adaptation may benefit post-CR participants via wearables and social media. Thus, we sought to explore the possible relationships of both the pandemic and technology on post-CR exercise maintenance.

Objective
This study aimed to (1) understand CR participation during the COVID-19 pandemic, (2) identify perceived barriers and facilitators to physical activity after CR completion, and (3) assess willingness to use technology and social media to support physical activity needs among older adults with cardiovascular disease.

Methods
We recruited participants aged 55 years and older in 3 different CR programs offered at both public and private hospitals in Northern California. We conducted individual interviews on CR experiences, physical activity, and potential for using technology. We used thematic analysis to synthesize the data.

Results
In total, 22 participants (n=9, 41% female participants; mean age 73, SD 8 years) completed in-depth interviews. Themes from participants’ feedback included the following: (1) anxiety and frustration about the wait for CR caused by COVID-19 conditions, (2) positive and safe participant experience once in CR during the pandemic, (3) greater attention needed to patients after completion of CR, (4) notable demand for technology during the pandemic and after completion of CR, and (5) social media networking during the CR program considered valuable if training is provided.

Conclusions
Individuals who completed CR identified shared concerns about continuing physical activity despite having positive experiences during the CR program. There were significant challenges during the pandemic and heightened concerns for safety and health. The idea of providing support by leveraging digital technology (wearable devices and social media for social support) resonated as a potential solution to help bridge the gap from CR to more independent physical activity. More attention is needed to help individuals experience a tailored and safe transition to home to maintain physical activity among those who complete CR.
Manejo de aneurismas cerebrales: Revisión de la literatura pasada, presente y futura
Authors: Campos Gamarra Rocío Nicole , Astudillo Palacios Mariana Gabriela , Gallo Guerrero Marla , Rojas Delgado Gonzalo , Palacios Garcia Jimmy 
Published: March 2024

Introducción: El manejo de los aneurismas cerebrales ha ido evolucionando con el paso de los siglos. En esta revisión se hace un resumen de cómo se ha desarrollado el manejo médico, endovascular y quirúrgico en el abordaje de estas patologías que causan una gran morbi-mortalidad en la población.
Objetivo: Evaluar el manejo médico, endovascular y quirúrgico de los aneurismas cerebrales rotos y no rotos a lo largo del tiempo, desde las primeras veces en que fueron tratados hasta las innovaciones que se están llevando a cabo.
Métodos: Se realizó una revisión de artículos buscados en la base de datos de PubMed, buscando Mesh Terms con palabras seleccionadas relacionadas al tema.
Diseño de estudio: Revisión.
Métodos: Selección de estudios con palabras clave de PubMed, y según consenso de todos los autores. Extracción de datos en Rayyan.
Palabras claves: hemorragia subaracnoidea, aneurisma, neurocirugia, procedimientos endovasculares.
Understanding dis-adoption of technologies by smallholder dairy farmers in Indonesia
Authors: Akzar Rida , Peralta Alexandra , Umberger Wendy 
Published: March 2024

Abstract
Farmer cooperatives represent a vertical coordination strategy aimed at reducing transaction costs and facilitating the adoption of technologies among farmers. In their roles, cooperatives undertake internal coordination of activities which may include enforcement measures, provision of quality inputs, internal control, and negotiation of favourable terms of exchange with buyers. However, limited attention has been given to understanding how cooperatives’ performance in the internal coordination of activities either promotes or hinders the continued adoption of agricultural technologies among cooperative members. We conducted a case study of the dairy sector in West Java, Indonesia, and utilised a mixed-method approach combining insight from dairy cooperative board members and dairy farming households. Our results suggest that the dis-adoption of dairy technologies is rooted in weak or non-existent monitoring and enforcement mechanisms to ensure input and output quality, the absence of price incentives, and inadequate provision of extension services. Furthermore, the lack of tight monitoring and control mechanisms reduces the cooperatives’ bargaining power with input providers and milk buyers. Unless these issues within the cooperatives are addressed, continued adoption of recommended dairy farming practices by smallholder farmers will not be sustained.
Penguatan employability skills dalam bidang penerbitan dan percetakan bagi siswa SMKN 11 Semarang
Authors: Harjono  , Cahyo Budi Utomo  , Sri Susilogati Sumarti  , Rakainsa Senda Kartika , Sigit Priatmoko  
Published: March 2024

Permasalahan kesiapan kerja/employability skill lulusan merupakan salah satu isu penting dari beberapa isu penting lainnya di sekolah menengah vokasi di Indonesia. Employability skill siswa SMKN 11 Semarang disiapkan melalui berbagai upaya sekolah baik dalam program pembelajaran kurikuler maupun ko-kurikuler. Para guru pembimbing menyadari adanya gap kemampuan dan keterampilan kerja siswa dalam bidang penerbitan & percetakan ini, oleh sebab itu diperlukan program nyata dalam upaya memberikan penguatan employability skill siswa. Program Pengabdian Kepada Masyarakat (PKM) ini ditujukan bagi siswa SMKN 11 Semarang yang sedang melaksanakan kegiatan PKL di industri sebagai upaya nyata memberikan bekal pengetahuan dan teknis bidang penerbitan dan percetakan. Model pendampingan secara langsung dilaksanakan oleh praktisi bidang penerbitan dan percetakan, dimulai dari pengenalan model bisinis penerbitan dan percetakan, peralatan cetak offset dan digital, finishing cetak, serta teknik perawatan mesin cetak sederhana. Selain itu, siswa juga di berikan wawasan dan mekanisme dalam penerbitan dan percetakan buku Melalui Pengabdian ini siswa SMKN 11 Semarang sudah mulai memahami terkait pentingya employability skill dalam dunia kerja. Meningkatnya pengetahuan tentang employabilty skill pada bidang penerbitan dan percetakan diharapkan dapat memberi peluang siswa dalam dunia kerja dan membuka lapangan kerja baru. Hardskill dan softskill yang didapatkan oleh siswa apabila dapat dikembangkan dan dijaga secara konsisten akan meningkatkan nilai branding siswa tersebut dalam dunia kerja. Pengabdian ini mungkin bisa diterapkan di sekolah kejuruan lain untuk membantu meningkatkan keterampilan siswa di bidang penerbitan dan percetakan.
Associations of Kidney Tubular Biomarkers With Incident Macroalbuminuria and Sustained Low eGFR in DCCT/EDIC
Authors: Limonte Christine P. , Gao Xiaoyu , Bebu Ionut , Seegmiller Jesse C. , Karger Amy B. , Lorenzi Gayle M. , Molitch Mark , Karanchi Harsha , Perkins Bruce A. , de Boer Ian H. ,   DCCT,   EDIC Research Group
Published: March 2024

OBJECTIVETubulointerstitial injury contributes to diabetic kidney disease (DKD) progression. We tested tubular biomarker associations with DKD development in type 1 diabetes (T1D).RESEARCH DESIGN AND METHODSWe performed a case-cohort study examining associations of tubular biomarkers, measured across seven time points spanning ∼30 years, with incident macroalbuminuria (“severely elevated albuminuria,” urinary albumin excretion rate [AER] ≥300 mg/day) and sustained low estimated glomerular filtration rate (eGFR) (persistent eGFR &lt;60 mL/min/1.73 m2) in the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study. Biomarkers included KIM-1 and sTNFR1 in serum/plasma, MCP-1 and EGF in urine, and a composite tubular secretion score reflecting secreted solute clearance. We assessed biomarkers using single values, as mean values from consecutive time points, and as change over consecutive time points, each as time-updated exposures.RESULTSAt baseline, mean diabetes duration was 5.9 years, with mean HbA1c 8.9%, eGFR 125 mL/min/1.73 m2, and AER 16 mg/day. There were 4.8 and 3.5 cases per 1,000 person-years of macroalbuminuria and low eGFR, respectively. Assessed according to single biomarker values, KIM-1 was associated with risk of subsequent macroalbuminuria and low eGFR (hazard ratio [HR] per 20% higher biomarker 1.11 [95% CI 1.06, 1.16] and 1.12 [1.04, 1.21], respectively) and sTNFR1 was associated with subsequent macroalbuminuria (1.14 [1.03, 1.25]). Mean KIM-1 and EGF–to–MCP-1 ratio were associated with subsequent low eGFR. In slope analyses, increases in KIM-1 and sTNFR1 were associated with subsequent macroalbuminuria (per 20% biomarker increase, HR 1.81 [1.40, 2.34] and 1.95 [1.18, 3.21]) and low eGFR (2.26 [1.65, 3.09] and 2.94 [1.39, 6.23]).CONCLUSIONSSerial KIM-1 and sTNFR1 are associated with incident macroalbuminuria and sustained low eGFR in T1D.
Análise e Soluções de Erros Sistêmicos que Acarretaram Saldos Contábeis Incorretos de Tributos Retidos na Fonte de Notas Fiscais Emitidas para Clientes
Authors: Vitalli Hugo do Carmo Missé , Marion José Carlos , Rodrigues Guerra Vanderley 
Published: March 2024

Objetivo principal da pesquisa: trazer os aspectos contábeis e sistêmicos (ERP) das retenções na fonte de tributos que incidem sobre notas fiscais de serviços prestados; esclarecer o momento de utilização desses créditos tributários para fins de compensação tributária; e de externalizar os problemas quanto a erros sistêmicos, os quais acarretaram distorções nos saldos contábeis.
Diagnóstico da problematização e/ou oportunidade: identificou-se erro sistêmico quanto ao recebimento do contas a receber de mais de uma nota fiscal emitida para um mesmo cliente; o ERP não efetuava a transferência dos saldos dos tributos retidos das contas tributos diferidos para as de tributos a compensar nos casos em que os clientes efetuavam o pagamento com diferença de casa decimal; e o ERP não efetuava a transferência dos saldos dos tributos retidos, das contas de tributos diferidos para as contas de tributos a compensar, nos processos de recebimento de NFs emitidas para os clientes que, com base em contrato firmado entre as partes, efetuaram o pagamento aplicando uma retenção de um valor pré-determinado em contrato, sob a rubrica de caução.
Metodologia/abordagem: o artigo baseou-se no método de estudo de caso, uma pesquisa exploratória e descritiva.
Resultados/aplicação: os resultados encontrados foram a correção dos saldos acumulados das contas de tributos retidos na fonte e possibilidade de efetuar as correções das apurações de PIS, Cofins, IRPJ e CSLL a fim de considerar os saldos corretos de tributos retidos na fonte.
Contribuições: trazer à luz o fato de que a Contabilidade Tributária e os processos sistêmicos do ERP precisam ser objeto de melhoria contínua para que as organizações adquiram confiabilidade nos negócios tributários.
FACTORS RELATED TO BPJS KESEHATAN PARTICIPATION IN TRADERS AMONG TRADERS
Authors: Muzhaffar Zaky , Suci Rahmadani  , Darmawansyah  
Published: March 2024

Background: BPJS Kesehatan plans for Universal Health Coverage in Indonesia to reach 98% in accordance with the National Medium-Term Development Plan (RPJMN).
Objective: This study aims to determine the factors associated with BPJS Health membership among traders in Pa'baeng-baeng Marketplace, Makassar City in 2023.
Method: This research is a quantitative study using a cross-sectional study design. The population in this study were 370 traders with a sample size of 160 traders. The sampling technique used was accidental sampling conducted at Pa'baeng-baeng Marketplace, Makassar City. Statistical tests using the chi-square test.
Result: The results showed that the factors that influence the participation of traders in BPJS Kesehatan are income (p=0.043), ability to buy (p=0.013), perception (p=0.000), and family support (p=0.000). Variables that are not associated with the participation of traders in BPJS Kesehatan are education variables (p=0.676) and the number of family members (p=0.563).
Conclusion: The conclusion of this study is that there is an influence between income, ability to buy, perceptions, and family support with BPJS Health participation among traders in Pa'baeng-baeng Marketplace, Makassar City in 2023.
DETERMINANTS OF STUNTING IN SEMARANG CITY
Authors: Roro Kushartanti  
Published: March 2024

Background : Stunting is not only a problem of physical growth disorders, but also causes children to become sick easily, brain and intelligence development also occurs. So, stunting is a big threat to the quality of human resources in Indonesia. The purpose of writing of this literature review is to collect determinants of Stunting in Semarang.
Objective : This research uses a literature revies from Google Scholar library sources, which is presented descriptively according to the problem formulation.
Result : Review from some of articles, found that maternal education level, maternal occupation, child order, birth length, child rearing patterns, exclusive breastfeeding status, family income, housing conditions, nutritional intake, and history of KEK are risk factors determining the incidence of Stunting in the Semarang.
Conclusions : Stunting prevention programs must be improved, by screening and monitoring the growth and development of babies and toddlers to prevent Stunting from an early age. Public is also advised to be more diligent in carrying out examinations at health services to monitor children’s growth and development.