bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shame in patient‐health professional encounters: A scoping review
Authors: Jaeb Michael A. , Pecanac Kristen E. 
Published: March 2024

AbstractShame can arise during patient‐health professional encounters when discussing traumatising and stigmatising topics and can contribute to negative patient outcomes. This review aims to summarise what is known regarding shame in patient‐health professional encounters. We conducted a scoping review using Levac and colleagues' approach and reported the findings using the PRISMA Extension for Scoping Reviews. We searched four databases (CINAHL, PsychINFO, PubMed and SocINDEX) for empirical studies that involved shame in patient‐health professional encounters contextualised by trauma or stigma and were published in English. We categorised what is known regarding shame in empirical studies using inductive content analysis. We also collected stakeholders' perspectives on the review findings through an online survey. Our initial search yielded 3658 articles, of which 37 were included. We summarised the literature into four categories: (1) What health professionals say they do in patient‐health professional encounters, (2) What health professionals think patients feel in patient‐health professional encounters, (3) Patients' descriptions of their own shame during patient‐health professional encounters and (4) Health professionals' descriptions of their own shame during patient‐health professional encounters. Shame can arise in a variety of circumstances during patient‐health professional encounters. More research is needed to identify what specific communication strategies used by health professionals during patient‐health professional encounters contribute to or avoid patient shame.
Preparing Future Designers for their Role in Co‐Design: Student Insights on Learning Co‐Design
Authors: Örnekoğlu‐Selçuk Melis , Emmanouil Marina , Hasirci Deniz , Grizioti Marianthi , Van Langenhove Lieva 
Published: March 2024

AbstractThe state‐of‐the‐art literature indicates an increasing need for co‐design education as it is imperative to equip future designers with the co‐designing mindset. This derives from the significance of involving ‘people with lived experience’ in co‐design processes to better meet their needs. However, the traditional design education system seems to include mostly individual designing skills, causing a lack of skills in design students to facilitate the active participation of people in co‐design. This paper reports on a case study carried out in a third‐year Bachelor industrial design engineering course with design students (n = 32) and design educators (n = 4) to find an effective and efficient way of preparing future designers for their role in co‐design and to gain insights into design students' experience with learning about co‐design. As an instructional method, a co‐design workshop including the game‐play, game‐modding and game‐design approaches is introduced. The obstacles and confusion of the design students regarding co‐design and co‐design education, which they have documented throughout the year on their personalised logbooks, are explained to eliminate them in the future for smoother incorporation of co‐design education into design education curricula. Lastly, for future designers' mindfulness of co‐design and their role as facilitators suggestions are provided such as accreditation of curriculum activities regarding co‐design education.
A Species‐Focused Approach to Assessing Speciesism
Authors: Murphy Alex 
Published: March 2024

ABSTRACTSpeciesism, broadly understood as the view that species membership is a morally relevant property, has been a central topic of debate within animal ethics for around 50 years. However, in all this time, animal ethicists have paid relatively scant attention to the nature of species membership itself. This seems potentially regrettable, since species membership's precise nature is presumably highly pertinent to the question of its exact moral relevance. Here, I advocate for a ‘species‐focused’ approach to assessing speciesism, arguing that, in debating the merits of speciesism, animal ethicists should (i) centre the nature of species membership, and (ii) consult philosophers of biology. Adherence to this second prescription appears necessary since a lot of what philosophers of biology believe regarding the nature of species membership appears contrary to what many animal ethicists have seemingly assumed.
An evidence‐based guideline on treating lumbar disc herniation with traditional Chinese medicine
Authors: Qin Xiaokuan , Sun Kai , Xu Weiguo , Gao Jinghua , Jiang Hong , Chen Wei , Zhang Ling , Li Zhenhua , Li Wuyin , Yuan Puwei , Yang Kexin , Tong Peijian , Zhong Yuanming , Zhu Xiaofeng , Wan Xiaoming , He Chengjian , Wang Yanguo , Xu Xilin , Huang Yong , Zhang Zhihai , Huang Yifei , Guo Wei , Cao Junling , Feng Tianxiao , Wang Xu , Yin Yuhui , Wang Hao , Sun Chuanrui , Xiao Xiangyu , Wei Xu , Zhu Liguo 
Published: March 2024

AbstractBackgroundLumbar disc herniation (LDH), as one of the most common causes of lower back pain, imposes a heavy economic burden on patients and society. Conservative management is the first‐line choice for the majority of LDH patients. Traditional Chinese medicine (TCM) is an important part of conservative treatment and has attracted more and more international attention.Study designEvidence‐based guideline.MethodsWe formed a guideline panel of multidisciplinary experts. The clinical questions were identified on the basis of a systematic literature search and a consensus meeting. We searched the literature for direct evidence on the management of LDH and assessed its certainty‐generated recommendations using the grading of recommendations, assessment, development, and evaluation (GRADE) approach.ResultsThe guideline panel made 20 recommendations, which covered the use of Shentong Zhuyu decoction, Shenzhuo decoction, Simiao San decoction, Duhuo Jisheng decoction, Yaobitong capsule, Yaotongning capsule, Osteoking, manual therapy, needle knife, manual acupuncture, electroacupuncture, Chinese exercise techniques (Tai Chi, Baduanjin, or Yijinjing), and integrative medicine, such as combined non‐steroidal anti‐inflammatory drugs, neural nutrition, and traction. Recommendations were either strong or weak, or in the form of ungraded consensus‐based statement.ConclusionThis is the first LDH treatment guideline for TCM and integrative medicine with a systematic search, synthesis of evidence, and using the GRADE method to rate the quality of evidence. We hope these recommendations can help support healthcare workers caring for LDH patients.
A converged ubiquitin‐proteasome pathway for the degradation of TOC and TOM tail‐anchored receptors
Authors: Yang Meijing , Chen Shuai , Lim Shey‐Li , Yang Lang , Zhong Jia Yi , Chan Koon Chuen , Zhao Zhizhu , Wong Kam‐Bo , Wang Junqi , Lim Boon Leong 
Published: March 2024

ABSTRACTIn plants, thousands of nucleus‐encoded proteins translated in the cytosol are sorted to chloroplasts and mitochondria by binding to specific receptors of the TOC (translocon on the outer chloroplast membrane) and the TOM (translocon on the outer mitochondrial membrane) complexes for import into those organelles. The degradation pathways for these receptors are unclear. Here, we discovered a converged ubiquitin‐proteasome pathway for the degradation of Arabidopsis thaliana TOC and TOM tail‐anchored receptors. The receptors are ubiquitinated by E3 ligase(s) and pulled from the outer membranes by the AAA+ adenosine triphosphatase CDC48, after which a previously uncharacterized cytosolic protein, transmembrane domain (TMD)‐binding protein for tail‐anchored outer membrane proteins (TTOP), binds to the exposed TMDs at the C termini of the receptors and CDC48, and delivers these complexes to the 26S proteasome.
Comparative study of clinical reasoning competence and self‐directed learning competence in nurses across varied years of experience
Authors: Liu Zhenya , Sun Na , Chen Cancan , Zhang Guifang , Hu Yanli 
Published: March 2024

AbstractObjectivesTo compare and analyse the differences in the clinical reasoning competence of nurses with different working years and their relationship with self‐directed learning competence.MethodsA cross‐sectional survey design (online investigation) was used. A total of 376 nurses were recruited from four independent hospitals in China. Online questionnaires collected data on nurses' demographic characteristics and assessed their clinical reasoning and self‐directed learning competence. Pearson correlation analysis, t‐test, analysis of variance (ANOVA) and multivariate regression analysis were used.ResultsClinical reasoning competence scores of nurses with working years >10 years were higher than those of other nurses. Self‐directed learning competence scores of nurses with working years of <1 year and (from ≥1 year to <3 years) were lower than those of nurses with working years of 6–10 years and >10 years. Self‐directed learning competence scores of nurses with working years of 3–5 years were lower than those of nurses with working years of >10 years. There was a positive correlation between clinical reasoning competence, self‐directed learning competence and each dimension among nurses of different working years. There are differences in the influence of different dimensions of self‐directed learning competence on clinical reasoning competence among different working years.ConclusionThere were differences in clinical reasoning and self‐directed learning competence among nurses with different working years. Self‐directed learning competence is a positive predictor of nurses' clinical reasoning competence, which applied to nurses with all working years; however, the specific effect of self‐directed learning competence on clinical reasoning competence differed among nurses with different working years.Implication for nursing managersNursing managers should pay attention to the development characteristics of clinical reasoning competence and self‐directed learning competence of nurses with different working years and determine effective intervention strategies according to specific influencing factors.
Moving mountains: Geography, neighborhood sorting, and spatial income segregation
Authors: Ye Victor Yifan , Becker Charles M. 
Published: March 2024

AbstractUsing a novel geospatial panel combined with data from the 2015 American Community Survey (ACS), we investigate the effect of topography—altitude and terrain unevenness—on income segregation at the neighborhood level. Specifically, we perform large‐scale counterfactual simulations by estimating household preferences for topography, altering the topographical profile of each city, and observing the resulting neighborhood sorting outcome. We find that unevenness contributes to the segmentation of markets: in the absence of hilliness, rich and poor households experience greater mixing. Hillier cities are more income‐segregated because of their unevenness; the opposite is true for flatter cities.
Psychometric properties of the Spanish version of the Health of Nation Outcome Scales for schizophrenia patients
Authors: Feria‐Raposo Isabel , García‐León María Ángeles , Rodríguez‐Cano Elena , Blanco‐Blanco Joan , Moreno‐Casbas María Teresa , Gonzalez‐Castro Ana Isabel , Gómez‐Lozano María José , Guerrero‐Pedraza Amalia , Sarri Carmen , Portillo Francisco , Sarró Salvador , McKenna Peter J. , Salvador Raymond , Pomarol‐Clotet Edith 
Published: March 2024

Accessible SummaryWhat is known on the subject?

Functioning is one of the most affected areas in schizophrenia. Social, occupational and personal domains are affected, and these deficits are responsible for a major part of the disability associated with the disorder.

There are several instruments to measure functioning, but the HoNOS provides a wide assessment of impairment in 12 areas of functioning.

What does the paper add to existing knowledge?

The Spanish version of the HoNOS shows good properties in terms of reliability and validity for use in schizophrenia patients.

Although some authors divide the scale according to proposed underlying dimensions, in schizophrenia this division may not be appropriate.

What are the implications for practice?

A reliable and easy‐to‐use measure of impairment in different areas of functioning is useful for optimizing the treatment and rehabilitation of patients with schizophrenia.

AbstractIntroductionThe HoNOS scale was designed for the assessment of psychosocial impairment in various domains. While it is widely used in psychiatric settings, it has not been validated in Spanish for use in patients with schizophrenia.AimTo examine the psychometric properties of the Spanish version of the HoNOS scale in a sample of schizophrenia patients.MethodA total of 194 individuals aged 18 to 65 with schizophrenia spectrum diagnoses were evaluated using the HoNOS. Illness severity and level of functioning were also assessed.ResultsThe HoNOS showed moderate internal consistency, good inter‐observer reliability and good test‐retest reliability. Factor analysis revealed an internal structure consisting of four factors, with item distribution differing from the theoretical dimensions proposed for the original scale.DiscussionThe Spanish version of the HoNOS scale is a reliable and valid instrument for assessing psychosocial impairment in individuals diagnosed with schizophrenia spectrum disorders. However, further research is needed to determine its internal structure more accurately.Implications for PracticeThe HoNOS scale provides researchers and clinicians with a valid measure of impairment in twelve different domains, which can facilitate and guide the treatment of schizophrenia patients.
Perceptual Narrowing in Face Processing: Reviewing the Factors Influencing its Onset and Offset
Authors: Fort Mathilde , Birulès Joan , Fratacci Althea , Parente Jonathan , Pascalis Olivier 
Published: March 2024

AbstractAn infant's face‐ and speech‐processing system develops during the first year from broad and non‐specific to becoming a system that is tuned to the faces and languages to which they are most exposed. This phenomenon is called perceptual narrowing. Before 9 months of age, infants are capable of discriminating and recognizing individuals from any type of race/species faces. However, with increased exposure to own‐race and own‐species faces and lack of exposure to other types of faces, by 9 months of age, they have improved their ability to discriminate own‐race faces, while they show increased difficulty in the discrimination of faces from other races and species. According to the literature, we can conclude that, by 12 months of age, most human perceptual systems have become perceptually tuned and adult‐like; however, this is not true. In the following sections, we will argue that perceptual narrowing for faces occurs during the same developmental period as it does for language, and that it can be prevented or modulated with sufficient exposure to unfamiliar sounds or face types. We conclude that narrowing has been designed by natural selection to tailor an individual's cognition to their local social context. It might occur for every domain pertaining to social communication—from speech processing to emotion or gesture perception—in a process that gradually adapts the infant to their native social group.
The emerging importance of cross‐ploidy hybridisation and introgression
Authors: Brown Max R. , Abbott Richard J. , Twyford Alex D. 
Published: March 2024

AbstractNatural hybridisation is now recognised as pervasive in its occurrence across the Tree of Life. Resurgent interest in natural hybridisation fuelled by developments in genomics has led to an improved understanding of the genetic factors that promote or prevent species cross‐mating. Despite this body of work overturning many widely held assumptions about the genetic barriers to hybridisation, it is still widely thought that ploidy differences between species will be an absolute barrier to hybridisation and introgression. Here, we revisit this assumption, reviewing findings from surveys of polyploidy and hybridisation in the wild. In a case study in the British flora, 203 hybrids representing 35% of hybrids with suitable data have formed via cross‐ploidy matings, while a wider literature search revealed 59 studies (56 in plants and 3 in animals) in which cross‐ploidy hybridisation has been confirmed with genetic data. These results show cross‐ploidy hybridisation is readily overlooked, and potentially common in some groups. General findings from these studies include strong directionality of hybridisation, with introgression usually towards the higher ploidy parent, and cross‐ploidy hybridisation being more likely to involve allopolyploids than autopolyploids. Evidence for adaptive introgression across a ploidy barrier and cases of cross‐ploidy hybrid speciation shows the potential for important evolutionary outcomes.
Integrated ATAC‐seq and RNA‐seq data analysis identifies transcription factors related to rice stripe virus infection in Oryza sativa
Authors: Li Miaomiao , Li Jing , Zhang Yan , Zhai Yushan , Chen Yi , Lin Lin , Peng Jiejun , Zheng Hongying , Chen Jianping , Yan Fei , Lu Yuwen 
Published: March 2024

AbstractAnimal studies have shown that virus infection causes changes in host chromatin accessibility, but little is known about changes in chromatin accessibility of plants infected by viruses and its potential impact. Here, rice infected by rice stripe virus (RSV) was used to investigate virus‐induced changes in chromatin accessibility. Our analysis identified a total of 6462 open‐ and 3587 closed‐differentially accessible chromatin regions (DACRs) in rice under RSV infection by ATAC‐seq. Additionally, by integrating ATAC‐seq and RNA‐seq, 349 up‐regulated genes in open‐DACRs and 126 down‐regulated genes in closed‐DACRs were identified, of which 34 transcription factors (TFs) were further identified by search of upstream motifs. Transcription levels of eight of these TFs were validated by reverse transcription‐PCR. Importantly, four of these TFs (OsWRKY77, OsWRKY28, OsZFP12 and OsERF91) interacted with RSV proteins and are therefore predicted to play important roles in RSV infection. This is the first application of ATAC‐seq and RNA‐seq techniques to analyse changes in rice chromatin accessibility caused by RSV infection. Integrating ATAC‐seq and RNA‐seq provides a new approach to select candidate TFs in response to virus infection.
The Ras GTPase‐activating protein UvGap1 orchestrates conidiogenesis and pathogenesis in the rice false smut fungus Ustilaginoidea virens
Authors: Cao Huijuan , Gong Hao , Yu Mina , Pan Xiayan , Song Tianqiao , Yu Junjie , Qi Zhongqiang , Du Yan , Zhang Rongsheng , Liu Yongfeng 
Published: March 2024

AbstractRas GTPase‐activating proteins (Ras GAPs) act as negative regulators for Ras proteins and are involved in various signalling processes that influence cellular functions. Here, the function of four Ras GAPs, UvGap1 to UvGap4, was identified and analysed in Ustilaginoidea virens, the causal agent of rice false smut disease. Disruption of UvGAP1 or UvGAP2 resulted in reduced mycelial growth and an increased percentage of larger or dumbbell‐shaped conidia. Notably, the mutant ΔUvgap1 completely lost its pathogenicity. Compared to the wild‐type strain, the mutants ΔUvgap1, ΔUvgap2 and ΔUvgap3 exhibited reduced tolerance to H2O2 oxidative stress. In particular, the ΔUvgap1 mutant was barely able to grow on the H2O2 plate, and UvGAP1 was found to influence the expression level of genes involved in reactive oxygen species synthesis and scavenging. The intracellular cAMP level in the ΔUvgap1 mutant was elevated, as UvGap1 plays an important role in maintaining the intracellular cAMP level by affecting the expression of phosphodiesterases, which are linked to cAMP degradation in U. virens. In a yeast two‐hybrid assay, UvRas1 and UvRasGef (Ras guanyl nucleotide exchange factor) physically interacted with UvGap1. UvRas2 was identified as an interacting partner of UvGap1 through a bimolecular fluorescence complementation assay and affinity capture‐mass spectrometry analysis. Taken together, these findings suggest that the UvGAP1‐mediated Ras pathway is essential for the development and pathogenicity of U. virens.
Intracardiac echocardiography‐guided catheter ablation of highly symptomatic accelerated idioventricular rhythm originating from the right ventricular apical diverticulum
Authors: Yang Sen , Li Sui , Li Shaolong , Liao Qiwei , Long Deyong , Li Mengmeng , He Chengde 
Published: March 2024

AbstractVentricular diverticula are saccule‐like structures formed by the protrusion of the ventricular myocardium from the endocardial surface towards the free wall. Most diverticula are muscular structures, and patients usually have no obvious clinical symptoms. However, diverticula may contribute to arrhythmogenesis due to localized myocardial structural disturbances. Right ventricular apical diverticulum (RVAD) is very rare, and we report a case of highly symptomatic accelerated idioventricular rhythm (AIVR) originating from the RVAD that underwent intracardiac echocardiography (ICE)–guided catheter ablation with no recurrence during follow‐up.
Mutant noxy8 exposes functional specificities between the chloroplast chaperones CLPC1 and CLPC2 in the response to organelle stress and plant defence
Authors: López Bran , Izquierdo Yovanny , Cascón Tomás , Zamarreño Ángel M. , García‐Mina José M. , Pulido Pablo , Castresana Carmen 
Published: March 2024

AbstractChloroplast function is essential for growth, development, and plant adaptation to stress. Organelle stress and plant defence responses were examined here using noxy8 (nonresponding to oxylipins 8) from a series of Arabidopsis mutants. The noxy8 mutation was located at the CLPC2 gene, encoding a chloroplast chaperone of the protease complex CLP. Although its CLPC1 paralogue is considered to generate redundancy, our data reveal significant differences distinguishing CLPC2 and CLPC1 functions. As such, clpc1 mutants displayed a major defect in housekeeping chloroplast proteostasis, leading to a pronounced reduction in growth and pigment levels, enhanced accumulation of chloroplast and cytosol chaperones, and resistance to fosmidomycin. Conversely, clpc2 mutants showed severe susceptibility to lincomycin inhibition of chloroplast translation and resistance to Antimycin A inhibition of mitochondrial respiration. In the response to Pseudomonas syringae pv. tomato, clpc2 but not clpc1 mutants were resistant to bacterial infection, showing higher salicylic acid levels, defence gene expression and 9‐LOX pathway activation. Our findings suggest CLPC2 and CLPC1 functional specificity, with a preferential involvement of CLPC1 in housekeeping processes and of CLPC2 in stress responses.