bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Probiotic Candidates in Artisanal Feta-Type Kefalonian Cheese: Unveiling a Still-Undisclosed Biodiversity
Authors: Lappa Iliada K. , Natsia Aikaterini , Alimpoumpa Dimitra , Stylianopoulou Electra , Prapa Ioanna , Tegopoulos Konstantinos , Pavlatou Chrysoula , Skavdis George , Papadaki Aikaterini , Kopsahelis Nikolaos 
Published: March 2024

AbstractAutochthonous dairy lactic acid bacteria (LAB) isolates encompass a natural source of starter, adjunct, or probiotic candidates. In this context, traditionally manufactured, using exclusively animal rennet, Feta-type cheeses were collected from five farms located in different regions of Kefalonia island (Greece). The primary objective of this study was to isolate and characterize novel LAB, thereby exploring the unmapped microbial communities of Kefalonian Feta-type cheese and identifying new potential probiotics. The initial screening, included a preliminary gastrointestinal (GI) tolerance assessment (acidic conditions and bile salts), followed by their safety evaluation (hemolytic activity and antibiotic susceptibility). Based on the preliminary screening, selected strains underwent molecular identification and were further investigated for their probiotic attributes (lysozyme and phenol resistance, antimicrobial traits, antidiabetic aspects, cholesterol reduction and adhesion, adhesion to Caco-2 cells, and milk acidification potential). The results showed that 49, out of the 93 retrieved isolates, exhibited resistance to GI conditions, whereas 18 met the safety criteria. The molecular identification revealed strains belonging to the species Lactiplantibacillus plantarum, Limosilactobacillus fermentum, Lacticaseibacillus rhamnosus, and Lacticaseibacillus paracasei. The selected rod-shaped 14 isolates displayed a potential probiotic character. The best-performing isolates concerning cholesterol assimilation and adhesion, α-glucosidase inhibition, and epithelial adherence were Lpb. plantarum F89, F162, and F254 and Lcb. paracasei F214 and F216, whereas Lcb. paracasei F70 showed potential as a defined strain starter. The present study explores for the first time the biodiversity of traditionally fermented microbial communities in Kefalonian Feta-type cheese, revealing novel potential probiotic strains that can contribute to the development of innovative functional food products.
Design and fabrication of an aluminium oxide cutting insert with an internal cooling channel
Authors: O’Hara John , Fang Feng-Zhou 
Published: March 2024

AbstractThis paper presents the design and fabrication of an aluminium oxide cutting insert with an internal cooling channel formed through an additive manufacturing method. The formed insert is subjected to a controlled densification process and analysed through a series of characterisation investigations. The purpose of the study is to develop the design concept and analyse the forming and sintering parameters used in the lithographic ceramic manufacturing process. The results validated the feasibility of the geometrical design, providing the required structural conformity with the integrated internal feature using conditional specifications. It is confirmed that the forming parameters would affect the material properties of the green body. Furthermore, the results indicate that the heating rate and temperature variance of the de-binding and thermal treatment regime influences the microstructural growth kinetics and the quality of the densified insert. Using a novel application of liquid gallium as an internal coolant, experimental results showed a decrease in tool wear difference of 36% at $$V_{{\text{c}}}$$

V
c

= 250 m/min, and 31% in tool wear difference at $$V_{{\text{c}}}$$

V
c

= 900 m/min between cooling and non-cooling conditions. When external cooling was applied, the results showed at $$V_{{\text{c}}}$$

V
c

= 250 m/min, the difference between the tool wear rates with the internal coolant relative to the external coolant was 29%. Increasing to $$V_{{\text{c}}}$$

V
c

= 900 m/min, the results revealed a 16% tool wear difference. The results clearly indicate the potential of liquid gallium as a heat transfer agent in internal cooling applications for cutting inserts, and by extension demonstrable reduction in tool wear.
Home telemonitoring in smart rurality: results from the HIS2R interreg feasibility pilot study
Authors: Schoevaerdts Didier , Lerude Marie-Paule , Tellier Véronique , Pierard Marie , Voilmy Dimitri , Novella Jean-Luc 
Published: March 2024

Abstract
Aims
The Health in Smart Rurality Interreg project aims to assess the feasibility of telemonitoring in rural areas across the Franco-Belgian border among patients affected by heart failure or chronic obstructive pulmonary disease. The objectives were to better understand strengths or barriers to implementing telemonitoring for early detection of potential adverse events, for improving quality of life, communication, and care coordination.

Methods
Using a prospective 6-month observational design, interconnected pads were provided to community-dwelling adults aged over 60 years. The device monitored daily body weight, temperature, cardiac rate, blood pressure, and oxygen saturation. Using predefined warning thresholds, data were analyzed by a nurse case-manager who also provided therapeutic education during their contacts.

Results
Out of 87 eligible and screened patients, 21 (24%) were included in the study. At the end of the follow-up, 19 patients (90%) were re-assessed. The rate of hospitalization and mortality was high (32% and 10%, respectively). A total of 644 alerts were recorded (median of 29 alerts/patients) with a high rate of technically-related alerts (TRA) (26%). Out of the 475 non-TRA, 79% and 1% have led to an intervention by the case-manager or the physician, respectively. Therapeutic adjustment was proposed for 12 patients during that period.

Conclusion
Telemonitoring appears to be a promising solution for the follow-up of patients living far from medical resources. The contribution of a case-manager is of added-value in managing alerts, therapeutic education, and coaching. Many questions remain open such as the improvement of technical aspects and long-term compliance in a real-world setting.
Diversification or sensory unification? Controversies around the senses in fin de siècle culture
Authors: Hernandez Barbosa Sonsoles 
Published: March 2024

AbstractThis article analyses the evolutionist discourses on the senses that emerged in the late 19th century, when theories on the evolution of species were in full sway. Drawing on newspapers, essays and medical literature, this article aims to set face to face the two currents of thought that I have identified regarding sensory evolution: the one that stressed the value of the progressive specialisation of the senses as evidence for human evolution mainly supported by Max Nordau, and the one which regarded the sensory regrouping, exemplified by the phenomenon of synaesthesia, as the true symptom of evolution, strongly supported by Victor Segalen. A close examination of their arguments will provide clues concerning their relative position vis-à-vis the theory that stressed the exceptional nature of humankind among all living beings. Based on newspapers, essays and medical literature, this paper, which straddles several fields (history of science, philosophy, cultural history and aesthetics) aims to set both positions face to face, examining their arguments in detail and establishing their genealogies. This will lead to a better understanding of the scope and range of evolutionist discourses in the fin de siècle culture and on their impact upon artistic practices.
Humanism Rounds: A Multifaceted “Back to Bedside” Initiative to Improve Meaning at Work for Internal Medicine Residents
Authors: Kaplan Jennifer M. , Agrawal Suchi , Kumar Disha , Xu Ann , Staggers Kristen A. , Symmes Anna G. , Styskel Reina U. , Styskel Brett , Agrawal Anoop , Rose Stacey R. 
Published: March 2024

Abstract
Introduction
Burnout is an increasingly prevalent problem among resident physicians. To address this problem, the Accreditation Council on Graduate Medical Education (ACGME) created the Back to Bedside initiative, supporting resident-driven projects focused on increasing direct interactions with patients. In 2017, Baylor College of Medicine (BCM) Internal Medicine Residency received a Back to Bedside grant to develop and implement “Humanism Rounds,” a multifaceted program which sought to promote personal connections between residents and patients and foster reflection about patients’ non-clinical stories, with the hopes of reducing burnout and increasing residents’ sense of meaning at work.

Materials and Methods
Between 2018 and 2020, internal medicine residents were instructed on and encouraged to participate in Humanism Rounds. The program included three components: taking a “human history,” bedside rounds focused on non-clinical concerns, and sharing patient stories with colleagues (“celebrations”). Residents were surveyed using institutional and ACGME surveys regarding burnout, meaning at work, and the clinical learning environment.

Results
Three hundred eleven institutional (response rate, 74%) and 328 AGCME (response rate, 78%) surveys were completed and analyzed. Residents who actively engaged with Humanism Rounds reported more meaning and fulfillment at work (p < 0.001). During the period of this project, ratings of the learning environment and personal callousness improved among subgroups of residents.

Conclusions
Baylor College of Medicine Internal Medicine residents who engaged with Humanism Rounds reported more meaning and fulfillment in their work. This program describes a low-cost model for other specialties and institutions to strengthen human connections and improve residents’ experience during training.
A graph neural network with negative message passing and uniformity maximization for graph coloring
Authors: Wang Xiangyu , Yan Xueming , Jin Yaochu 
Published: March 2024

AbstractGraph neural networks have received increased attention over the past years due to their promising ability to handle graph-structured data, which can be found in many real-world problems such as recommender systems and drug synthesis. Most existing research focuses on using graph neural networks to solve homophilous problems, and not much attention has been paid to heterophily-type problems. In this paper, we propose a graph network model for graph coloring, which is a class of representative heterophilous problems. Different from the message passing in conventional graph networks, we introducenegative message passinginto a physics-inspired graph neural network for more effective information exchange in handling graph coloring problems. Moreover, a new term in the objective function taking into account the information entropy of nodes is suggested to increase the uniformity of the color assignment of each node, giving the neural network more chance to choose suitable colors for each node. Therefore, it could avoid the final solution getting stuck into the local optimum. Experimental studies are carried out to compare the proposed graph model with five state-of-the-art algorithms on ten publicly available graph coloring problems andd-regular graphs with up to$$10^4$$104nodes, demonstrating the effectiveness of the proposed graph neural network.
The logic of carbon substitution: from fossilised life to “cell factories”
Authors: Ehrenstein Véra , Rudge Alice 
Published: March 2024

AbstractThis paper examines how researchers in biotechnology reflect on the challenges of turning microbes into what they call “cell factories”. These researchers use the tools of genome editing to harness the biochemistry of single cell organisms, such as bacteria, yeasts and microalgae, and tweak the enzymatic reactions of their metabolism. One research priority is to engineer microbes able to feed on agricultural residues and assemble drop-in compounds to be used in a range of commercial products, from drugs and food additives, to cosmetics, detergents and fuels. To justify financial support for such research, arguments about the need to move away from petroleum as a source of energy and feedstock for chemical synthesis are put forward, underpinned by concerns for climate change, resource renewability and energy security. Drawing on interviews with scientists, we explore what it means for them to make “cell factories” and discuss how they problematise the logic of carbon substitution that orientates their work. Biotechnology is expected to support a shift from one source of carbon, past life gone through slow geological cycles, to a different source of carbon, renewable biomass metabolised by living microbes. As scientists face unhappy cells, recalcitrant plant fibres and unfair competition from fossil-based processes, the promise of carbon substitution tends to be most convincing in the confined space of the lab where faith in biotechnology goes hand in hand with a pragmatic commitment to sustainability. We speculate that the researchers might be failed by the system that biotechnology seeks to (partially) replace, the conditions of which are shaped not around the material constraints of making “cell factories”, but around fossilised life cracked in ever-greater quantities.
Assessment of particulate matter and particle path trajectory analysis using a HYSPLIT model over Dire Dawa, Ethiopia
Authors: Endale Teshager Argaw , Raba Gelana Amente , Beketie Kassahun Ture , Feyisa Gudina Legese , Gebremichael Haftu Brhane 
Published: March 2024

AbstractThis work deals with the assessment of particulate matter (PM1, PM2.5, and PM10) over Dire Dawa during the month of May 2021. In the study, purple sensor (PS) and gravimetric methods (GM) were used. The purple sensor was to provide real-time measurements of PM1.0, PM2.5, and PM10 particulates. The GM instruments were constructed using wood with 1 m height (distance to ground), with flat board on top of which filter papers were placed to collect particulate matter. The difference in filter paper weight before and after sampling was used to calculate the particle masses. By dividing the weight gain of the filter by the amount of air measured, the concentrations of suspended particulate matter in the defined size range were estimated. The mean value of PM10indicated a good status whereas the mean value of PM2.5revealed a moderate condition as far as pollution is concerned. The purple sensor detected relatively higher values for PM10measurement as compared to GM method during the study period. According to the calculated results of the ratio of mass concentration of PM1.0 to PM10, coarse particles were dominant whereas in the ratio of PM2.5to PM10both coarse and fine mode particles were equally present during the sampling period. The spatial distribution showed variations depending on the locations where the sampling filter papers were placed. The HYSPLIT backward trajectory analysis indicated various air masses and transport channels during different seasons. The predominant pathways were from both urban and desert origins.
Telemedicine and Pediatric Care in Rural and Remote Areas of Middle-and-Low-Income Countries: Narrative Review
Authors: Alnasser Yossef , Proaño Alvaro , Loock Christine , Chuo John , Gilman Robert H. 
Published: March 2024

Abstract
Objectives
Caring for children in low- and middle-income countries (LMIC) can be challenging. This review article aims to explore role of telemedicine in supporting pediatric care in LMIC.

Methodology
A narrative review of existing English and Spanish literature was conducted to assess role of telemedicine to support pediatric care in LMIC.

Results
Beside medical education and direct pediatric care, telemedicine can provide sub-specialties consultations without extra burden on families. Additionally, telemedicine can help in lowering under-5 mortality by supporting neonatal care, infectious illnesses, and non-communicable diseases (NCDs). Telemedicine can be a gate for universal coverage for all children at a lower cost. For over a decade, it has been implemented successfully and sustained in a few LMIC. However, challenges in implementing telemedicine are enormous. Still, opportunities arise by using simpler technology, low-width band internet, smartphones, instant messaging applications and solar energy. COVID-19 pandemic facilitated acceptance and applicability of telemedicine worldwide including LMIC. Nevertheless, governments must regulate telemedicine by issuing policies and ensuring employment of local experts when possible to meet local resources and cultural competency.

Conclusion
Telemedicine has proven successful in improving pediatrics care. Many LMIC should take advantage of this innovation to promote equity and access to high quality pediatric care.
Fertility dynamics during COVID-19: exploring intentions in rural Bangladesh
Authors: Sultana Yasmin 
Published: March 2024

AbstractThis paper investigates the impact of the COVID-19 pandemic on fertility intentions among families in the Rangpur region of Bangladesh, considering various socio-economic and demographic characteristics. The study aims to understand how the COVID-19 pandemic influenced fertility decisions, patterns, and how different contextual factors are relevant to explain those intentions. This study adopted a qualitative methodological approach, utilizing a non-probability purposive sampling procedure to select sixty-five rural women as participants who conceived babies during the COVID-19 pandemic and seven health care providers. Data were collected through semi-structured interviews and KII to explore the factors influencing intentional and unintentional childbirths during the pandemic. The findings revealed that, among the respondents, intentional childbirths were more prevalent than unintentional childbirths. The perceived causes of intentional childbirth in rural areas were pandemic-induced factors, demographic characteristics and societal practices to have a baby. The factors to unintentional childbirth were limited access to reproductive health care services and contraceptives, leading to unplanned pregnancies. Additionally, the study highlights that COVID-19 related economic and health conditions did not have a significant impact on fertility decisions in rural areas. Societal norms and attitudes towards family planning, childbearing and family size played key roles in determining birth intentions. Overall, the research emphasizes the need for targeted policies and initiatives to address the challenges of fertility planning during a health crisis.
Crypto and financial literacy of cryptoasset owners versus non-owners: The role of gender differences
Authors: Balutel Daniela , Engert Walter , Henry Christopher , Huynh Kim P. , Rusu Doina , Voia Marcel C. 
Published: March 2024

AbstractWe measure crypto and financial literacy using microdata from the Bank of Canada’s Bitcoin Omnibus Survey. Our crypto literacy measure is based on three questions covering basic aspects of Bitcoin. The financial literacy measure we use is based on three questions covering basic aspects of conventional finance (the “Big Three”). We find that a significant share of Canadian Bitcoin owners have low crypto knowledge and low financial literacy. We also find gender differences in crypto literacy among Bitcoin owners, with female owners scoring lower in Bitcoin knowledge than male owners. We do not, however, find significant gender differences in financial literacy amongst Bitcoin owners. In contrast, non-owners show gender differences in both crypto and financial literacy.
Environmental cleaning and disinfection in the operating room: a systematic scoping review through a human factors and systems engineering lens
Authors: Xie Anping , Sax Hugo , Daodu Oluseyi , Alam Lamia , Sultan Marium , Rock Clare , Stewart C. Matthew , Perry Shawna J. , Gurses Ayse P. 
Published: March 2024

AbstractObjective:To synthesize evidence and identify gaps in the literature on environmental cleaning and disinfection in the operating room based on a human factors and systems engineering approach guided by the Systems Engineering Initiative for Patient Safety (SEIPS) model.Design:A systematic scoping review.Methods:Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched 4 databases (ie, PubMed, EMBASE, OVID, CINAHL) for empirical studies on operating-room cleaning and disinfection. Studies were categorized based on their objectives and designs and were coded using the SEIPS model. The quality of randomized controlled trials and quasi-experimental studies with a nonequivalent groups design was assessed using version 2 of the Cochrane risk-of-bias tool for randomized trials.Results:In total, 40 studies were reviewed and categorized into 3 groups: observational studies examining the effectiveness of operating-room cleaning and disinfections (11 studies), observational study assessing compliance with operating-room cleaning and disinfection (1 study), and interventional studies to improve operating-room cleaning and disinfection (28 studies). The SEIPS-based analysis only identified 3 observational studies examining individual work-system components influencing the effectiveness of operating-room cleaning and disinfection. Furthermore, most interventional studies addressed single work-system components, including tools and technologies (20 studies), tasks (3 studies), and organization (3 studies). Only 2 studies implemented interventions targeting multiple work-system components.Conclusions:The existing literature shows suboptimal compliance and inconsistent effectiveness of operating-room cleaning and disinfection. Improvement efforts have been largely focused on cleaning and disinfection tools and technologies and staff monitoring and training. Future research is needed (1) to systematically examine work-system factors influencing operating-room cleaning and disinfection and (2) to redesign the entire work system to optimize operating-room cleaning and disinfection.
Applying a Social Ecological Model to Medical Legal Partnerships Practice and Research
Authors: McLaren Susan , Bliss Lisa Radtke , Scott Christina , Kraidler Pam , Pettignano Robert 
Published: March 2024

AbstractThe social ecological model (SEM) is a conceptual framework that recognizes individuals function within multiple interactive systems and contextual environments that influence their health. Medical Legal Partnerships (MLPs) address the social determinants of health through partnerships between health providers and civil legal services. This paper explores how the conceptual framework of SEM can be applied to the MLP model, which also uses a multidimensional approach to address an individual’s social determinants of health.
The small heat shock protein Hsp20.8 imparts tolerance to high temperatures in the leafminer fly, Liriomyza trifolii (Diptera: Agtomyzidae)
Authors: Zhang Yue , Chang Ya-Wen , Wang Yu-Cheng , Yan Yu-Qing , Du Yu-Zhou 
Published: March 2024

AbstractAs an environmental factor, temperature impacts the distribution of species and influences interspecific competition. The molecular chaperones encoded by small heat shock proteins (sHsps) are essential for rapid, appropriate responses to environmental stress. This study focuses on Hsp20.8, which encodes a temperature-responsive sHsp in Liriomyza trifolii, an insect pest that infests both agricultural and ornamental crops. Hsp20.8 expression was highest at 39℃ in L. trifolii pupae and adults, and expression levels were greater in pupae than in adults. Recombinant Hsp20.8 was expressed in Escherichia coli and conferred a higher survival rate than the empty vector to bacterial cells exposed to heat stress. RNA interference experiments were conducted using L. trifolii adults and prepupae and the knockdown of Hsp20.8 expression increased mortality in L. trifolii during heat stress. The results expand our understanding of sHsp function in Liriomyza spp. and the ongoing adaptation of this pest to climate change. In addition, this study is also important for predicting the distribution of invasive species and proposing new prevention and control strategies based on temperature adaptation.