bluuebunny/crossref_metadata_2025_split huggingface dataset:
DNA Methylation Patterns in Umbilical Cord Blood from Infants of Methadone Maintained Opioid Dependent Mothers
Authors: Adegboyega Oluwatobi O. , Betal Suhita Gayen nee’ , Urday Pedro , Huang Rachel , Bodycot Katherine , Al-Kouatly Huda B. , Solarin Kolawole , Chan Joanna SY. , Addya Sankar , Boelig Rupsa C. , Aghai Zubair H. 
Published: April 2024

Abstract

Methadone maintenance treatment for opioid dependent mothers is standard of care. Infants of methadone maintained opioid dependent (MMOD) mothers have better outcomes compared to infants of opioid dependent mothers without treatment. However, when compared to non-exposed infants, infants of MMOD mothers are associated with worse outcomes. We conducted a pilot study to examine genome wide differential DNA methylation using cord blood samples from sixteen term and near-term infants of MMOD and opioid naïve mothers, excluding Infants with chorioamnionitis. A total of 152 differentially methylated loci were identified at a difference > + 2, < -2 and p-value < 0.05. There were 90 hypermethylated loci (59 annotated genes) and 62 hypomethylated loci (38 annotated genes) observed. The hypermethylated and hypomethylated DNA changes involved multiple genes, pathways and networks that may explain some of the changes seen in infants of MMOD mothers. Top hypermethylated and hypomethylated genes involved areas of cell growth, neurodevelopment, vision and xenobiotic metabolism functions. Our data may explain the role of key pathways and genes relevant to neonatal outcomes seen from methadone exposure in pregnancy. Functional studies on the identified pathways and genes could lead to improved understanding of the mechanisms and identify areas for intervention.
Assessing Formal Mental Health Help-seeking Perceptions, and Attitudes towards Campus-based Mental Healthcare Services amongst University Students in Rwanda.
Authors: Ingabire Sandrine , Norvixoxo Kwame Samuel 
Published: April 2024

Abstract

Mental health issues are prevalent among college students, but only a fraction of them seek professional mental health support. This is especially so in Africa where there is little to no sufficient mental health services. The lack of comprehensive data about prevalence further exacerbates the problem. The aim of this study is to assess perceptions, behaviour and attitudes towards formal mental health help-seeking behaviour among university students. The study used a mixed-method design and employed an online survey to collect data from 185 college students enrolled in 15 universities in Rwanda. A descriptive approach was used in analysing the data. The study found that the majority of students (61.6%) acknowledged the value of seeking help, and perceived mental disorders to be like any other medical illnesses. However, only 9.7% of that number sought professional help. Privacy concerns, trust issues and perceived lack of comfort when seeking help were the main justifications why they did not seek mental help support. Participants overall showed positive attitudes towards campus-based mental healthcare services. However, they are hesitant to patronise these services due to the unavailability of established wellness centres in some schools. Also, due to the limited number of trained mental health professionals in Rwanda, some of the wellness centres in these higher education institutions employ students. This could explain the trust and privacy concerns raised by the students. Consequently, they prefer informal ways of seeking help, such as talking to friends and family, as they deem them more trustworthy. However, none of the study participants could account for the sufficiency of this approach. The study recommends the use of digital platforms that will leverage access to professional mental healthcare in and outside of Rwanda for students.
Identification of potential Ferroptosis-Related Biomarkers and Immune Infiltration in Human Atrial Fibrillation
Authors: Wang Dinghui , Yang Huiping , Xiong Tianhua , Xiong Bingquan , She Qiang , Liu Bin 
Published: April 2024

Abstract

Background
The role of structural remodeling in the development and persistence of atrial fibrillation atrial fibrillation (AF) is significant, although its mechanism remains unknown at present. This study aims to explore the transcriptomic mechanisms of AF structural remodeling through bioinformatics analysis.
Methods
These microarrays GSE14975, GSE31821 and GSE79768 were acquired from the GEO database. Next, a series of bioinformatics methods were used, such as R language, DAVID, STING, and Cytoscape software, to study the DEG between AF and control samples. Then, we found genes related to ferroptosis from FerrDb database and conducted joint analysis with differentially expressed genes (DEG). In addition, we predicted several transcription factors that regulate DEG and conducted immune infiltration analysis using CIBERSORT software.
Results
a total of 363 up-regulated DEGs and 308 down-regulated DEGs were identified from atrium cordis samples of 16 AF patients and 13 controls. Functional changes of DEGs mainly focus on positive regulation of inflammatory response, signal transduction, inflammatory response, immune response, oxidation-reduction process and extracellular matrix organization. Eleven DE-FRGs were identified, including HSPB1, ALOX15, ETV4, ACO1, CHAC1, FH, PARP15, IFNG, ACSL1, FABP4 and IL1B and several TFs (POLE2, GATA5, CEBPA, ATF3, MEF2C) were predicted via Cytoscape software. Macrophage M2 was found to occupy the largest proportion of all the immune cells.
Conclusion
The occurrence of AF may be a result of fibrosis caused by myocardial cell ferroptosis and imbalance of the immune microenvironment. Obtained DE-FRGs HSPB1, ALOX15, ETV4, ACO1, CHAC1, FH, PARP15, IFNG, ACSL1, FABP4 and IL1B and predicted TFs POLE2, GATA5, CEBPA, ATF3, MEF2C can be seen as potential targets for preventing AF.
Study on selected properties of the surface layer of magnesium alloys after impulse shot peening
Authors: Skoczylas Agnieszka , Zaleski Kazimierz , Ciecieląg Krzysztof , Matuszak Jakub 
Published: April 2024

Abstract

Shot peening is a commonly used method of finishing machine elements in the manufacturing process. One variation of shot peening is the impulse shot peening. This paper presents the influence of impulse shot peening technological conditions on the surface roughness (parameters Ra and Rt) and topography, microhardness. The FEM was used to determine the S11 stresses. In the experiment and simulation tests, AZ31 and AZ91HP magnesium alloy samples were used. Variable parameters in the impulse shot peening process were: impact energy E: 15 ÷ 185 mJ, ball diameter d: 3 ÷ 15 mm and impact density j: 3 ÷ 44 mm− 2. As a result of the tests carried out, it was found that after impulse shot peening, the surface topography is change, microirregularities are flattened, numerous depressions are formed, which can be potential lubrication pockets. The 2D surface roughness parameters for most impulse shot peening conditions are lower than for the pre-machining. The roughness parameters for magnesium alloy AZ91HP are lower than for AZ31. This is most likely due to the lower elongation A. The microhardness after impulse shot peening increased by 20 HV to 87 HV. As a result of FEM of the impulse shot peening, compressive stresses S11 were created in the surface layer. The depth of occurrence of S11 stresses is from 1.5 to 3.5 mm, and their value for the AZ91HP magnesium alloy samples are 10–25% lower than for the AZ31 alloy samples. The most favorable results of the tested properties of the surface layer were obtained for E = 100 mJ, d = 10 mm, j = 11 mm− 2.The abstract serves both as a general introduction to the topic and as a brief, non-technical summary of the main results and their implications.
WITHDRAWN: The ability of Lupine plant extract to adhere to copper surfaces in sulphamic acid and prevent corrosion
Authors: Alatawi Raedah A.S. , Keshk Ali A. , Alhawiti Aliyah S. , Bukhari Abeer Abdulaziz H. , Alatawi Omar M. , Elsayed Nadia H. , Al-Rasheed Hessa H. 
Published: April 2024

Abstract
The application of lupine extract in a 2 M sulfamic acid (H2NSO3H) solution effectively prevented copper corrosion. Various techniques were employed to conduct these experiments, including mass loss ML, dynamic potential polarization PL, and electrochemical impedance EIS. Theoretical calculations, such as DFT, Fukui function, and Monte Carlo simulations, were also utilized. FT-IR spectroscopy was utilized to analyze the surface composition of Cu. The shape of the Cu surface was determined using advanced nanotechnology techniques, specifically scanning electron microscopy (SEM). The investigation focused on the impact of Lupine extract on Cu corrosion in sulfamic acid at a temperature of 250C. The inhibition rate of Cu corrosion was assessed using mass loss (ML) as the primary measurement method. After conducting a thorough analysis of its interaction with copper surfaces, it was determined that the substance exhibits chemical adsorption characteristics and adheres to the Langmuir isotherm model. Upon examining the PL curves, it becomes evident that the Lupine extract functions as a mixed-type inhibitor. The effectiveness of inhibition was observed to rise as the concentration of Lupine increased. Furthermore, the findings demonstrate that increased temperatures have a detrimental impact on the effectiveness of inhibition. The density functional theory (DFT) and Monte Carlo simulation (MC) were utilized to compare the experimental results with the theoretical calculations.
The Effectiveness of Socially Assistive Robots in Improving Children’s Pain and Negative Affectivity during Needle-based Invasive Treatment: A Systematic Review and Meta-analysis
Authors: Pan Xin-yun , Bi Xuan-yi , Nong Yan-ning , Ye Xu-chun , Yan Yan , Shang Jing , Zhou Yi-min , Yao Yu-zhe 
Published: April 2024

Abstract

Background The ability of socially assistive robots (SARs) to treat dementia and Alzheimer’s disease has been verified. Currently, to increase the range of their application, there is an increasing amount of interest in using SARs to relieve pain and negative emotions among children in routine medical settings. However, there is little consensus regarding the use of these robots. Objective This study aimed to evaluate the effect of SARs on pain and negative affectivity among children undergoing invasive needle-based procedures. Design This study was a systematic review and meta-analysis of randomized controlled trials that was conducted in accordance with the Cochrane Handbook guidelines. Methods The PubMed, Embase, EBSCO, Web of Science, Cochrane Library, Embase, CNKI, and WanFang databases were searched from inception to January 2024 to identify relevant randomized controlled trials (RCTs). We used the Cochrane Risk of Bias tool 2.0 (RoB2.0) to assess the risk of bias among the included studies, and we used RevMan 6.3 software to conduct the meta-analysis. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) framework was used to assess the quality of the evidence. Results Ten RCTs involving 815 pediatric subjects were selected for this review and reported outcomes related to pain and emotions during IV placement, port needle insertion, flu vaccination, blood sampling, and dental treatment. Children undergoing needle-related procedures with SARs reported less anxiety (SMD= -0.36; 95% CI= -0.64, -0.09; P = 0.01) and fewer distressed avoidance behaviors (SMD= -0.67; 95% CI= -1.04, -0.30; P = 0.0004) than did those receiving typical care. There were nonsignificant differences between these groups in terms of in pain (SMD = -0.02; 95% CI = − 0.81, 0.78; P = 0.97) and fear (SMD = 0.38; 95% CI= -0.06, 0.82; P = 0.09). The results of exploratory subgroup analyses revealed no statistically significant differences based on the intervention type of robots or anesthetic use. Conclusions The use of SARs is a promising intervention method for alleviating anxiety and distress among children undergoing needle-related procedures. However, additional high-quality randomized controlled trials are needed to further validate these conclusions. Registrations The protocol of this study has been registered in the database PROSPERO (registration ID: CRD42023413279).
Role of CD64 on CD14+ CD16+ Monocytes in Mediating the Effect of genus Collinsella on Nonalcoholic Fatty Liver Disease
Authors: Yu Ru yi , Chen Guoyong , xia dong 
Published: April 2024

Abstract
Objective Previous Mendelian randomization (MR) studies have explored the association between gut microbiota and nonalcoholic fatty liver disease (NAFLD), but the role of monocytes in this relationship remains unclear.Methods We performed a bidirectional and mediation Mendelian randomization(MR) study using summary statistics from the genome-wide association studies of gut microbial taxa (Dutch Microbiome Project, n = 7738), immune cells (GWAS Catalog, (accession numbers from GCST0001391 to GCST0002121, n = 3757), and NAFLD (the FinnGen study, 2568 cases and 409613 controls). We utilized two-sample MR analysis to assess the association between gut microbes and NAFLD and calculated the mediating effects of immune cells on this association. The primary methods for causal inference were Inverse Variance Weighting (IVW) test and Bayesian Weighted Mendelian Randomization (BWMR). A sensitivity analysis was also conducted to ensure the robustness of our results.Results genus Collinsella is the most significant taxon causally associated with NAFLD among five microbial taxa [odds ratio = 1.453, 95% confidence interval (CI) = 1.120–1.883, P-value = 0.0048]. The BWMR analysis confirmed this causal relationship. The univariable MR analysis showed that CD64 on CD14 + CD16 + monocyte was causal immune cell for NAFLD. (OR = 1.227, 95% CI = 1.036–1.453, P = 0.018). The mediation MR analysis showed that CD64 on CD14 + CD16 + monocyte mediated the causal effects of genus Collinsella on NAFLD (proportion mediated = 13.5%, 95% CI = 1.4–30.8%).Conclusion Our study identified a causal relationship between genus Collinsella and NAFLD, with a proportion of the effect mediated by a specific monocyte.
Collision Avoidance Method for Unmanned Ships by Using A Modified APF Algorithm
Authors: Li Lianbo , Wu Wenhao , Li Zhengqian , Wang Fangjie 
Published: April 2024

Abstract
This paper proposed a dynamic collision avoidance method based on Artificial Potential Field (APF) algorithm for unmanned ships, and improves the defects of traditional APF respectively: In order to make unmanned ships perform collision avoidance operation safely and comply with good seamanship and the Convention on the International Regulations for Preventing Collisions at Sea, 1972 (COLREGS), this paper introduces a ship domain priority judgment encounter situation, so that the algorithm can make collision avoidance operations compatible with the actual; For the path interference and target unreachability problems, this paper introduces a new attractive potential field function for improvement, which divides the attractive potential field of the target point into multiple segments simultaneously. Meanwhile, the repulsive force on own ship is reduced when own ship is close to the target point, to avoid the path interference and overcome the target unreachability problem. Finally, for the path oscillation problem, this paper refers to partial ideas of the Dynamic Window Approach (DWA) to integrate the potential field based on the traditional APF. By comparing with the traditional APF algorithm, the overall smoothing degree is improved by 71.8% comprehensively, and the effectiveness and superiority of the algorithm are verified.
Comparative evaluation of haemato-biochemical and oxidative stress markers in natural patent and latent infection of Theileria equi in horses
Authors: Parashar Rahul , Singla L.D. , Kaur Paramjit , Sharma S.K. 
Published: April 2024

Abstract
Relative association of haemato-biochemical findings with oxidative stress markers was evaluated between natural patent and latent infection of Theileria equi in horses to divulge the roll of these parameters in the pathogenesis of illness due to non-availablity in literature. Blood was collected from 429 equines of 16 districts of the Punjab and samples positive by microscopy (patent Group I; n = 13), by polymerase chain reaction (PCR) (latent group II; n = 38) and healthy control (group III, n = 64) were compared for haematological-biochemical index and stress parameters. Significant anaemia in both group I and group II, and considerable neutrophilia and lymphocytopenia in group I in comparison to group II and group III was observed. Significant elevation in creatinine, aspartate aminotransferase and glucose while reduction in iron was noticed in both group I and group II. More level of lipid peroxides in patent group I followed by latent group II indicated more lipid peroxidation in erythrocytes and oxidative stress in declining order when compared with Group III. Superoxide dismutase (SOD), reduced glutathione (GST) and ferric reducing antioxidant power (FRAP) levels were lowered in Group I. An inverse association of RBC count with lipid peroxidation (PLO) and GSH and a direct relationship with catalase, SOD and FRAP was revealed. Findings indicated that oxidative damage plays an imperative function in pathogenesis of anaemia in horses due to T. equi infection and can be utilized as significant marker for latent and patent infection after well thought-out correlation with other haemato-biochemical findings.
Aerosol Optical Depth Retrieval on Particulate Observing Scanning Polarimeter (POSP) Data over Land using a new Look-up table (LUT) Search Method
Authors: Ji Zhe , Li Zhengqiang , Zhang Ying , Ma Yan , Shi Zheng , Yan XiaoXi , Xie Yisong , Zheng Yang , Chen Zhenting 
Published: April 2024

Abstract

Accurate estimation of Land Surface Reflectance (LSR) is the key to Aerosol Optical Depth (AOD) retrievals. However, it is noted that the band-specific LSRs retrieved using Look-Up Tables (LUTs) are typically pseudo-LSRs obtained by atmospheric corrections to the AOD predetermined in the LUTs that do not match the surface constraints established by the true LSRs alone. As a result, there is an uncertain error in modeling reflectance at the top of atmosphere (TOA) using pseudo-LSRs calculated by linear interpolation. This study proposed a new LUT search method to improve the AOD retrievals of the Particle Observing Scanning Polarimetry (POSP) sensor onboard the China GaoFen-5 (02) satellite. LSR atmospherically corrected using ERA5 reanalysis data and POSP AOD products for the year 2022 was adopted to create a new full-spectrum LSR self-consistent surface constraint. Results showed that the AOD of POSP in January 2023 retrieved using the new method agrees with the ground-truth AOD values from AErosol RObotic NETwork (AERONET) site observations with the correlation coefficient (R) at 0.703 and the root mean square error (RMSE) at 0.068. 76.77% of the values fell into the expected error (EE) envelope of range ± (0.05 + 0.15 AODAERONET), and 67.35% met the accuracy requirements of the Global Climate Observing System (GCOS).
Mixed polyanion Na2O-CuO-V2O5-P2O5 glass and glass ceramic cathode network: Relationship between structure and electrochemical performance
Authors: Grandhe Radhika , KATTA VAMSI KRISHNA , Padala Missak Swarup Raju , Ravuri Balaji Rao 
Published: April 2024

Abstract
This investigation presents mixed polyanion G-NaCu1 − x(VO)xPO4 (x = 0.1, 0.3, 0.5,0.7and 0.9 mol%) glass-based cathode material network prepared using the melt-quenching process followed by heat-treating at its Tcfor 5h to form its glass-ceramic(GC- NaCu1 − x(VO)xPO4). The best crystalline NaV2O5 (ICSD 760908) NaCu(PO4)(ICSD 581303), and Na2Cu(P2O7)(ICSD 556822) phases precipitated in the glass network during crystallization will accommodate sudden volume changes, resulting to trigger the fast diffusion of Na+ ions in the glass-ceramic network leading to fast rate capability and voltage for longer durations. The lowest charge transfer resistance Rct = 7.086x103Ω from 1st to 1000 cycles and highest retention of discharge capacity (99.71%) when the current rate is decreased from 10C to 0.1C, determines its long-term cycle life stability and rate capability more than other crystalline compounds.
The relationship between perfectionism and quality of sleep: A cross-sectional study among Sudanese medical students
Authors: Elbadawi Mohamed H. , Mubasher Amr A. , Abdulgalil Alaa A. , Fadul Mohamed H. , Elameen Nafisa Elameen Nimir , Elamin Ragad Magdi Mohammed , Mohamed Waad A. , Alsaid Aya Mujtaba Taha 
Published: April 2024

Abstract

Background :
Perfectionism is characterized by the pursuit of perfection, the imposition of unreasonably high standards for performance, and a constant state of self-criticism of one's actions. Perfectionism leading to depression, OCD, and anxiety can affect the quality of sleep, leading to less productivity and less involvement in one's daily activities. One of the most affected groups is medical students who are more likely to develop sleep-deprived lifestyles; this can be due to the stressful environment of medical school and the perceived high academic load. This study aims to address the association between perfectionism among medical students and sleep quality.
Method :
The study utilized an analytical and facility-based cross-sectional study conducted in March 2023 at the Faculty of Medicine, University of Khartoum, Sudan. We used two validated questionnaires which are: The Frost Multidimensional Perfectionism Scale (F-MPS and the Pittsburgh Sleep Quality Index (PSQI). Data was collected using an online self-administered questionnaire via social media platforms. Analysis has been done using SPSS version 21 by descriptive statistics, univariate analysis, and regression.
Results:
233 medical students were included in the study. Almost 56% of them were females. Almost 60% of the sample suffered from poor sleep quality. There weren't any significant mean differences observed in gender or age regarding perfectionism and sleep quality. Only two domains of perfectionism were found to be significantly associated with sleep quality:” concerns over mistakes and doubts of action” and “concern with parent expectation and evaluation”( P < 0.01 for both domains). There was a positive and significant association between the total perfectionism scale and sleep quality(r = 0.222, P < 0.01).
Conclusion :
There is growing evidence of the association between sleep quality and perfectionism. Our study highlighted this association among medical students. We found that there was a small positive and significant association between total the perfectionism scale and sleep quality. But neither gender nor academic year showed to be contributing to this association. So our study demonstrates the effect of perfectionism in disturbing the sleep quality unbiased by either gender or academic year with potential clinical and therapeutic applications. These findings can benefit the medical students in the University of Khartoum and other medical students.