bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Experiental Marketing dan Store Atmosphere Terhadap Loyalitas Pelanggan di Rumah Makan Bebek Cak Anton Jombang
Authors: Darmadi  , Ningsih Lilis Sugi Rahayu 
Published: March 2024

Penelitan ini bertujuan untuk mengetahui pengaruh Experiental Marketing dan Stor Atmosphere terhadap loyalitas pelanggan pada Rumah Makan Bebek Cak Anton Jombang. Metode yang digunakan pada penelitian ini adalah metode penelitian kuantitatif dan Jumlah sampel yang digunakan sebanyak 35 konsumen dengan menggunakan teknik pengambilan nonprobility sampling. Teknik pengumpulan data menggunakan kuesioner. Uji hipotesis menggunakan Uji t, Uji F, dan uji R2. Hasil penelitian ini menunjukan bahwa (1) Experiental Marketing berpengaruh secara parsial terhadap Loyaliotas Pelanggan di Rumah Makan Bebek Cak Anton Jombang dengan nilai thitung 2.623 > ttabel 1.693 (2) Store Atmosphere berpengaruh secara parsial terhadap Loyaliotas Pelanggan di Rumah Makan Bebek Cak Anton Jombang dengan nilai thitung 2.990 > ttabel 1.693 (3) Experiental Marketing dan Store Atmosphere berpengaruh secara silmutan terhadap loyalitas pelanggan di Rumah Makan Bebek Cak Anton Jombang dengan nilai fhitung 10.043 > ftabel 2.91.
Pengaruh Komunikasi Organisasi dan Komitmen Organisasi Terhadap Kepuasan Kerja (Studi Kasus Pada Karyawan Unit Jahit Line 1 dan Line 2 PT. Karya Mekar Dewatamali Jombang)
Authors: Pinasthi Denice Fitria , Mahfudiyanto  
Published: March 2024

Tujuan dari penelitian ini adalah untuk mengetahui bagaimana komunikasi organisasi dan komitmen organisasi berdampak pada kepuasan kerja karyawan PT. Karya Mekar Dewatamali Jombang (studi kasus karyawan baris 1 dan baris 2). Penelitian ini menggunakan metode pendekatan kuantitatif dan kausal. Subyek penelitian adalah karyawan PT. Karya Mekar Dewatamali Jombang yang bekerja di line jahit 1 dan 2. Sampel jenuh digunakan sebagai teknik pemgambilan sampel yang terdiri dari 77 pegawai. SPSS v.23 program dignuakan untuk oengelolaan data.. Perolehan data analisis menunjukkan bahwa kepuasan kerja karyawan dipengaruhi oleh komunikasi organisasi dan komitmen organisasi
Pengaruh Harga, Promosi Dan Kualitas Pelayanan Terhadap Loyalitas Pelanggan Pada Toko Besi 99 Jaya Trowulan Mojokerto
Authors: Tamimi Muhammad Rosyid , Santoso Rohmad Prio 
Published: March 2024

Tujuan dari penelitian ini untuk mengetahui pengaruh Harga, Promosi, dan Kualitas pelayanan terhadap Loyalitas Pelanggan. Penelitian ini mengambil Objek pada Toko Besi 99 Jaya Trowulan Kab. Mojokerto. Hasil penelitian ini menggunakan Sampling incidental terhadap 40 konsumen Toko Besi 99 Jaya Trowulan Kab. Mojokerto. Hasil penelitian menunjukan (1) Pengaruh Harga berpengaruh secara parsial terhadap Loyalitas Pelanggan pada Toko Besi 99 Jaya Trowulan (2) Pengaruh Promosi berpengaruh secara parsial terhadap Loyalitas pelanggan pada Toko Besi 99 Jaya Trowulan (3) Pengaruh Kualitas Pelayanan Berpengaruh secara parsial terhadap Loyalitas pelanggan pada Toko Besi 99 Jaya Trowulan (4) Pengaruh Harga, Promosi, dan Kualitas pelayanan berpengaruh secara simultan dan signifikan terhadap Loyalitas pelanggan pada Toko Besi 99 Jaya Trowulan
Multiplexing of TMT labeling reveals folate-deficient diet-specific proteome changes in NTDs
Authors: Pei Pei , Shen Jinying , He Xuejia , Zeng Yubing , Zhang Ting , Wang Shan 
Published: March 2024

Introduction: In the early stage of embryonic development, the neural tube (NT) cannot be closed properly due to some complex factors, including environmental factors, genetic factors, and the relationship between various factors, leading to the occurrence of neural tube defects (NTDs).Methods: In this study, we induced a mouse model of NTDs by feeding mice with a low-folate diet and intraperitoneally injecting them with 1.5 mg/kg methotrexate on E7.5. Fetal mice were achieved at E13.5, and we extracted proteins from brain tissues with trypsin digestion. After enzymatic digestion, peptides were labeled with TMT/iTRAQ and separated in high-performance liquid chromatography (HPLC) for subsequent liquid chromatography tandem mass spectroscopy (LC-MS/MS) analysis. We used gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation to analyze proteomic changes and analyze the functional enrichment of differentially expressed proteins (DEPs) in the NTD mice tissues.Results: A low-folate-induced mouse model was successfully constructed. Folate was used as a sensitizing agent, and the teratogenicity rate of the NTD fetal mice increased to 36.5% when the concentration of methotrexate was at 1.5 mg/kg. Mass spectrometry was used to identify 6,614 proteins, and among them, 5,656 proteins were quantified. In the following proteomic analysis, GO classification and KEGG pathway enrichment analysis were conducted, and heatmaps were drawn for differentially expressed proteins (DEPs). The main pathways associated with NTDs, such as the Hedgehog, Wnt, p53, and Hippo signaling pathways and the one-carbon pool mediated by folate, can be identified through a protein–protein interaction (PPI) network. It was also found that the regulation of ribosomal proteins, such as RPL13 and RPL14, which are upregulated in NTDs, has a certain impact on neural tube development.Discussion: Our results revealed proteomic changes in the tissues of low-folate-induced NTD mice. Validation showed that ribosomal proteins play a regulatory role during the development of NTDs and provides new ideas for the pathogenesis and preventive measures of NTDs.
The impact of endovascular stents types on perioperative outcomes of ruptured abdominal aortic aneurysms: a single-center experience
Authors: Ma Huibo , Wang Xueyi , Liu Yangshuo , Li Yongxin , Guo Mingjin 
Published: March 2024

IntroductionRuptured abdominal aortic aneurysm (rAAA) represents a critically urgent vascular surgical condition, and endovascular aneurysm repair (EVAR) is a clinically effective treatment option. This study aims to investigate whether the type of intravascular graft used for ruptured abdominal aortic aneurysms has an impact on perioperative outcomes of EVAR.MethodsA retrospective analysis was conducted on patients who underwent EVAR for ruptured abdominal aortic aneurysm at a single medical center from 2019 to 2022. Patients who required simultaneous stent implantation in the renal arteries or visceral arteries, as well as those with ruptured aneurysms located in the para-renal, supra-renal, or thoracoabdominal regions, were excluded from the analysis. Additionally, patients who underwent open surgery during the initial procedure or converted to open repair were excluded. The primary endpoint was perioperative mortality rate. Other study outcomes included perioperative complications, reoperation rates, and length of hospital stay. Characteristics and corresponding outcomes of patients receiving different endovascular stent treatments were compared using SPSS software.ResultsA total of 58 patients received treatment with two types of endovascular stents: Gore Excluder (n = 29) and Microport Hercules (n = 29). The number of other endografts was too small for statistical analysis. Compared to patients treated with Hercules, those treated with Excluder had a significantly increased likelihood of concomitant coronary atherosclerosis (P = 0.009) and potentially higher creatinine levels (P = 0.014). Additionally, Excluder was more commonly used in patients with shorter aneurysm necks (P &lt; 0.001). There was a statistically significant difference in overall mortality between the two groups (Hercules 27.6%, Excluder 6.9%, P = 0.037). Furthermore, patients who received Excluder treatment had lower mortality rates in subgroups of non-alcohol users (P = 0.028), non-diabetic patients (P = 0.027), and patients with dispersed thrombosis at the proximal neck (P = 0.046). In the multivariate analysis, the type of stent used (OR 0.06, 95% CI 0.00–1.31) and the occurrence of intraoperative complications (OR 20.70, 95% CI 1.14–76.70) in patients with rAAA was identified as an independent risk factor for perioperative mortality.ConclusionOur study suggests that the management of intraoperative complications may be a modifiable factor that can improve outcomes. Patients receiving Excluder treatment demonstrated better performance in EVAR for single-center rAAA patients compared to other endovascular stents, and this difference warrants further investigation.
Techno-economic feasibility assessment and performance analysis of standalone solar photo voltaic-biomass hybrid system with optimized storage: a case study—Grand Bassa, Liberia
Authors: White Jackson G. , Samikannu Ravi , Oladiran Moses Tunde , Yahya Abid , Makepe Patricia , Gamariel Gladys , Ladu Nyagong Santino David , Tlhabologo Bokang Agripa , Kadarmydeen Maruliya Begam , Gunasekaran Kanimozhi , Amuhaya Lilian 
Published: March 2024

Introduction: Liberia has a significant obstacle in terms of restricted power accessibility, as only 26.7% of its populace have access to electrical energy. To tackle this issue, there is a collaborative effort between the government and private sector to undertake energy projects aimed at enhancing the power supply of the grid. The purpose of this study is to evaluate the techno-economic feasibility and analyze the performance of a standalone biomass/solar photovoltaic (PV) hybrid energy system for a rural Liberian community that mostly relies on traditional biomass.Methods: HOMER pro program was used to configure the system, model the community’s load over a year, and generate the resource data of the location.Results and Discussion: Four different configurations were obtained and analyzed both technically and economically to determine the most feasible configuration. This study has shown that a hybrid configuration incorporating Biomass Gasifier, Solar PV, and Battery storage is more feasible with annual output power of 77104 kWh/yr, LCOE ($/kwh) of 0.29 and NPC ($) of 0.3979 million. If implemented with external funding, it will enhance the education, economic and socio-economic status of rural settlements. The results will serve as a valuable resource for informing choices on the implementation of the hybrid energy solution and guaranteeing its sustained efficacy within the community.
Nonlinear spatial impacts of the digital economy on urban ecological welfare performance: evidence from China
Authors: Wang Sen , Li Jinye 
Published: March 2024

IntroductionWith the rapid development of digital technology and its deep integration with environmental and ecological fields, the digital economy has become an effective way to guide the transition of cities to an eco-friendly model. However, empirical studies on the nonlinear spatial effects between digital economy and ecological welfare performance are still insufficient.MethodsBased on the panel data of 270 prefecture-level cities in China from 2011 to 2020, this paper empirically examines the impact of the digital economy on the ecological welfare performance of cities and its mechanism of action using spatial econometric modeling.ResultsThe promotion effect of digital economy development on the ecological welfare performance of cities is characterized by the “J” shape of increasing marginal effect, and the spatial spillover effect on the ecological welfare performance of neighboring cities is the inverted “U” shape of inhibiting first and then promoting later. The mechanism test shows that the development of digital economy can enhance the ecological welfare performance of cities through the marginal incremental promotion of green technological innovation in local and neighboring cities and has a positive spatial spillover effect. The development of digital economy can have a direct U shape effect on local ecological welfare performance by influencing factor allocation efficiency and energy utilization efficiency. It also has an inverted U-shaped spatial spillover effect. Environmental regulation has an inverted U-shaped moderating effect on the local eco-welfare performance affected by the digital economy. As the level of rural revitalization increases, it produces a U-shaped moderating effect of inhibiting. Heterogeneity analysis reveals that digital economy development has a more significant facilitating effect and a positive spatial spillover effect on the ecological welfare performance of cities in central China.DiscussionThis paper will provide a reference for the synergistic optimization of digital economy development and ecological welfare performance among regions. The findings of the study will promote the development of digital economy and accelerate the realization of the goal of “Beautiful China”.
Real-world experience of teriflunomide in relapsing multiple sclerosis: paramagnetic rim lesions may play a role
Authors: Tan Hongmei , Li Xiang , Li Yuxin , He Fanru , ZhangBao Jingzi , Zhou Lei , Yang Liqin , Zhao Chongbo , Lu Chuanzhen , Dong Qiang , Li Haiqing , Quan Chao 
Published: March 2024

ObjectivesThe aims of this study were to report the effectiveness and safety of teriflunomide in Chinese patients with relapsing–remitting multiple sclerosis (RRMS) and to explore the association of paramagnetic rim lesion (PRL) burden with patient outcome in the context of teriflunomide treatment and the impact of teriflunomide on PRL burden.MethodsThis is a prospective observational study. A total of 100 RRMS patients treated with teriflunomide ≥3 months were included in analyzing drug persistence and safety. Among them, 96 patients treated ≥6 months were included in assessing drug effectiveness in aspects of no evidence of disease activity (NEDA) 3. The number and total volume of PRL were calculated in 76 patients with baseline susceptibility-weighted imaging (SWI), and their association with NEDA3 failure during teriflunomide treatment was investigated.ResultsOver a treatment period of 19.7 (3.1–51.7) months, teriflunomide reduced annualized relapse rate (ARR) from 1.1 ± 0.8 to 0.3 ± 0.5, and Expanded Disability Status Scale (EDSS) scores remained stable. At month 24, the NEDA3% and drug persistence rate were 43.8% and 65.1%, respectively. In patients with a baseline SWI, 81.6% had at least 1 PRL, and 42.1% had ≥4 PRLs. The total volume of PRL per patient was 0.3 (0.0–11.5) mL, accounting for 2.3% (0.0%–49.0%) of the total T2 lesion volume. Baseline PRL number ≥ 4 (OR = 4.24, p = 0.009), younger onset age (OR = 0.94, p = 0.039), and frequent relapses in initial 2 years of disease (OR = 13.40, p = 0.026) were associated with NEDA3 failure. The PRL number and volume were not reduced (p = 0.343 and 0.051) after teriflunomide treatment for more than 24 months. No new safety concerns were identified in this study.ConclusionTeriflunomide is effective in reducing ARR in Chinese patients with RRMS. Patients with less PRL burden, less frequent relapses, and relatively older age are likely to benefit more from teriflunomide, indicating that PRL might be a valuable measurement to inform clinical treatment decision.
Transcription termination and readthrough in African swine fever virus
Authors: Cackett Gwenny , Sýkora Michal , Portugal Raquel , Dulson Christopher , Dixon Linda , Werner Finn 
Published: March 2024

IntroductionAfrican swine fever virus (ASFV) is a nucleocytoplasmic large DNA virus (NCLDV) that encodes its own host-like RNA polymerase (RNAP) and factors required to produce mature mRNA. The formation of accurate mRNA 3′ ends by ASFV RNAP depends on transcription termination, likely enabled by a combination of sequence motifs and transcription factors, although these are poorly understood. The termination of any RNAP is rarely 100% efficient, and the transcriptional “readthrough” at terminators can generate long mRNAs which may interfere with the expression of downstream genes. ASFV transcriptome analyses reveal a landscape of heterogeneous mRNA 3′ termini, likely a combination of bona fide termination sites and the result of mRNA degradation and processing. While short-read sequencing (SRS) like 3′ RNA-seq indicates an accumulation of mRNA 3′ ends at specific sites, it cannot inform about which promoters and transcription start sites (TSSs) directed their synthesis, i.e., information about the complete and unprocessed mRNAs at nucleotide resolution. MethodsHere, we report a rigorous analysis of full-length ASFV transcripts using long-read sequencing (LRS). We systematically compared transcription termination sites predicted from SRS 3′ RNA-seq with 3′ ends mapped by LRS during early and late infection. ResultsUsing in-vitro transcription assays, we show that recombinant ASFV RNAP terminates transcription at polyT stretches in the non-template strand, similar to the archaeal RNAP or eukaryotic RNAPIII, unaided by secondary RNA structures or predicted viral termination factors. Our results cement this T-rich motif (U-rich in the RNA) as a universal transcription termination signal in ASFV. Many genes share the usage of the same terminators, while genes can also use a range of terminators to generate transcript isoforms varying enormously in length. A key factor in the latter phenomenon is the highly abundant terminator readthrough we observed, which is more prevalent during late compared with early infection. DiscussionThis indicates that ASFV mRNAs under the control of late gene promoters utilize different termination mechanisms and factors to early promoters and/or that cellular factors influence the viral transcriptome landscape differently during the late stages of infection.
The effectiveness and safety of lifestyle medicine and integrative therapies in inflammatory arthritis: an umbrella review using a hierarchical evidence gathering approach
Authors: Lin Joshua , Liu Jing , O’Fee Allana , Pandey Chhiti , Benna-Doyle Sarah , Maunder Alison , Rao Vibhuti , Alesi Simon , Ng Beverly , Ee Carolyn 
Published: March 2024

ObjectiveAn umbrella review was conducted to provide a comprehensive evaluation of the evidence on lifestyle medicine and integrative therapies for inflammatory arthritis.MethodsFive electronic databases were searched for umbrella reviews, meta-analyses, and systematic reviews of randomised controlled trials on acupuncture, diet, exercise, herbal medicine, nutrient supplements, and mind–body therapies for rheumatoid arthritis, spondyloarthritis, and gout published from January 2012 to December 2022. The primary outcomes were functional status and quality of life. Quality assessment was performed using the A MeaSurement Tool to Assess systematic Reviews (AMSTAR-2) tool, and the certainty of evidence for our primary outcomes was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach where possible.ResultsWe included 52 reviews. Exercise was beneficial for functional status in both rheumatoid arthritis and spondyloarthritis, with moderate certainty of evidence. Chinese herbal medicine in combination with disease-modifying anti-rheumatic drugs may improve functional status in rheumatoid arthritis (very low certainty evidence). Acupuncture may improve functional status in rheumatoid arthritis and pain in both rheumatoid arthritis and gout; however, the evidence is of very low certainty. Evidence for other therapies was not clinically significant; however, it suggests possible benefits from quercetin and polyunsaturated fatty acids. Yoga may result in a moderate improvement in functional status when used as an adjunct to medication; however, the certainty of evidence is very low. Diet interventions offered inconsistent improvements to functional status in rheumatoid arthritis, spondyloarthritis, and gout with low to very low certainty.ConclusionExercise should be prescribed for people with rheumatoid arthritis and spondyloarthritis. More research is needed to confirm or refute evidence for Chinese herbal medicine, acupuncture, yoga, and anti-inflammatory diets.
Unraveling trajectories from aplastic anemia to hematologic malignancies: genetic and molecular insights
Authors: Kim Namsoo , Choi Yu Jeong , Lee Seung-Tae , Choi Jong Rak , Lyu Chuhl Joo , Shin Saeam , Cheong June-Won 
Published: March 2024

BackgroundAplastic anemia (AA), characterized by hematopoietic stem cell deficiency, can evolve into different hematologic malignancies. Our understanding of the genetic basis and mechanisms of this progression remains limited.MethodsWe retrospectively studied 9 acquired AA patients who later developed hematologic malignancies. Data encompassed clinical, laboratory, karyotype, and next-generation sequencing (NGS) information. We explored chromosomal alterations and mutation profiles to uncover genetic changes underlying the transition.ResultsNine AA patients developed myelodysplastic syndrome (seven patients), acute myeloid leukemia (one patient), or chronic myelomonocytic leukemia (one patient). Among eight patients with karyotype results at secondary malignancy diagnosis, monosomy 7 was detected in three. Trisomy 1, der(1;7), del(6q), trisomy 8, and del(12p) were detected in one patient each. Among three patients with NGS results at secondary malignancy diagnosis, KMT2C mutation was detected in two patients. Acquisition of a PTPN11 mutation was observed in one patient who underwent follow-up NGS testing during progression from chronic myelomonocytic leukemia to acute myeloid leukemia.ConclusionThis study highlights the genetic dynamics in the progression from AA to hematologic malignancy. Monosomy 7’s prevalence and the occurrence of PTPN11 mutations suggest predictive and prognostic significance. Clonal evolution underscores the complexity of disease progression.
Development of a prognostic model based on different disulfidptosis related genes typing for kidney renal clear cell carcinoma
Authors: Feng Yuanyuan , Wang Wenkai , Jiang Shasha , Liu Yongming , Wang Yan , Zhan Xiangyang , Zhu Huirong , Du Guoqing 
Published: March 2024

Background: Kidney renal clear cell carcinoma (KIRC) is a common and clinically significant subtype of kidney cancer. A potential therapeutic target in KIRC is disulfidptosis, a novel mode of cell death induced by disulfide stress. The aim of this study was to develop a prognostic model to explore the clinical significance of different disulfidptosis gene typings from KIRC.Methods: A comprehensive analysis of the chromosomal localization, expression patterns, mutational landscape, copy number variations, and prognostic significance of 10 disulfide death genes was conducted. Patients were categorized into distinct subtypes using the Non-negative Matrix Factorization (NMF) typing method based on disulfidptosis gene expression patterns. Weighted Gene Co-expression Network Analysis (WGCNA) was used on the KIRC dataset to identify differentially expressed genes between subtype clusters. A risk signature was created using LASSO-Cox regression and validated by survival analysis. An interaction between risk score and immune cell infiltration, tumor microenvironment characteristics and pathway enrichment analysis were investigated.Results: Initial findings highlight the differential expression of specific DRGs in KIRC, with genomic instability and somatic mutation analysis revealing key insights into their role in cancer progression. NMF clustering differentiates KIRC patients into subgroups with distinct survival outcomes and immune profiles, and hierarchical clustering identifies gene modules associated with key biological and clinical parameters, leading to the development of a risk stratification model (LRP8, RNASE2, CLIP4, HAS2, SLC22A11, and KCTD12) validated by survival analysis and predictive of immune infiltration and drug sensitivity. Pathway enrichment analysis further delineates the differential molecular pathways between high-risk and low-risk patients, offering potential targets for personalized treatment. Lastly, differential expression analysis of model genes between normal and KIRC cells provides insights into the molecular mechanisms underlying KIRC, highlighting potential biomarkers and therapeutic targets.Conclusion: This study contributes to the understanding of KIRC and provides a potential prognostic model using disulfidptosis gene for personalized management in KIRC patients. The risk signature shows clinical applicability and sheds light on the biological mechanisms associated with disulfide-induced cell death.