bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on YOLOv8 Object Detection Algorithm in UAV Scenarios
Authors: Li Shixin , Chen Fankai , Sun Zhongyuan , Zhu Zhiren , Zhou Liming , Tang Kaiwen 
Published: March 2024

Abstract

Aerial images captured by Unmanned Aerial Vehicles (UAVs) often exhibit characteristics such as high object density, small targets, and wide coverage, which lead to the occurrence of false positives and false negatives in existing object detectors. In order to improve detection accuracy, this study proposes an enhanced YOLOv8 object detection model. Firstly, the Deformable Convolutional Networks v2 (DConv2) is incorporated into the backbone's C2F module to expand the receptive field of the image and enhance the detection accuracy of small objects. Secondly, the Fousion Block module is employed in the neck network to increase network depth and strengthen feature fusion capability. Subsequently, the model incorporates up sampling operations and discards large object detection layers, further improving the detection progress for small objects. Finally, the Efficient Intersection over Union (ECIoU) loss function is adopted to replace the Complete Intersection over Union (CIoU) loss function, accelerating the model's convergence speed and enhancing object detection precision. The improved model is validated using the VisDrone2019-DET-train dataset, and the results demonstrate that the enhanced model Yolov8s_UAU achieves anmAP of 49.5%, representing a 7.3% improvement over traditional models. With the capability to maintain UAV detection speed, the proposed model can more accurately accomplish the detection tasks for small targets during UAV aerial photography processes.
AE-YOLOv5 for Detection of Power Line Insulator Defects
Authors: Shen Wei , Fang Ming , Wang Yuxia , Zhang Weifeng , Xiao Jiafeng , Chen Huangqun 
Published: March 2024

Abstract
The power transmission network, which delivers power energy from generator to customers, plays an important role in the power grid. Insulator is a basic component in the power transmission network. Its defects may lead to the paralysis of the entire transmission network, resulting in serious electricity accidents. Therefore, how to use artificial intelligence and other emerging technologies to realize automatic detection of power line insulator defects has become an urgent problem to be solved. To accurately detect insulator defects in complex environment, this paper proposes Attention Enhanced YOLOv5 (AE-YOLOv5) by inserting visual attention modules into original YOLOv5 model. In particular, we design a Channel-Spatial Attention module and plug it into the backbone of YOLOv5 to enhance its representation learning ability. Furthermore, a Multi-scale Attention module is also proposed to enhance the Feature Pyramid Network (FPN). To validate the efficacy of our proposed model, we conducted training and testing on a dataset collected from real-world scenarios. The experimental results demonstrate that our model can effectively and accurately detect defects of power line insulators in real-time.
The Influence of Walking environment on the Sports Participation Willingness and Physiological and psychological health of Urban Residents: Evidence from Western China
Authors: Liu Li , Zhang Tingran , Liu Yongsen , luo jiong 
Published: March 2024

Abstract
Objective
To explore the impact of community walking environment on residents' willingness to participate in sports and health status in western China's urban communities.
Methods
this study takes the layout of community fitness paths in the Chengdu-Chongqing Economic Zone community of western China as the survey object, and uses SPSS 21.0 statistical analysis software to process the obtained database.
Results
The choice of fitness path is not related to the gender and personal income of residents, but rather to their educational level, occupational category, and age; The exercise willingness of residents is influenced by factors such as the safety of the exercise path, the safety of the surrounding environment, residential density, accessibility of public facilities, the quality of the path facilities, the path landscape, and the size of the space.
Conclusion
The exercise willingness is the most important factor affecting the physiological and psychological health of residents. Improving the exercise obstacles in the walking environment and further ensuring the safety of the exercise process and fitness facilities is the key to enhancing the exercise willingness of residents.
Applying new criteria for higher education campuses to serve special-needs students, A Case Study of the AASTMT Alexandria Campus
Authors: Darwish Nancy Farouk 
Published: March 2024

Abstract
This research focuses on addressing the challenges faced by disabled individuals, particularly in the context of higher education buildings in Egypt. Despite the increasing percentage of people with disabilities in the country, many students with physical impairments are unable to attend universities due to the lack of accessibility in campus buildings. The main difficulty is how to create an environment where diverse students with varying requirements, abilities, preferences, and moods can study the same curriculum simultaneously. This study aims to evaluate the accessibility of a specific campus, the AASTMT, by comparing it with a successful example, Goldsmiths, University of London. This research identified areas for improvement, outdoor elements such as outdoor obstacles, accessible parking, clear signage, easy entrances, curb ramps, pathways, and steps, and indoor elements such as insufficiently accessible toilets, lifts, stairs, and fixed furniture hindering wheelchair use. The case study concluded that the AASTMT was successful for 80% of the evaluated criteria. This research emphasizes the importance of implementing elements that facilitate independent movement for students with physical impairments.
Comparación de las respuestas de ansiedad, depresión y estrés en dos grupos de estudiantes universitarios
Authors: Gómez Ramos Jhoana Lorena , Rodríguez Sepúlveda Gina Estefan , Villa Orozco María Clara 
Published: March 2024

Durante el transcurso de la pandemia por el síndrome respiratorio agudo severo (SARS-Cov-2), que se presentó desde el año 2020, se evidenció la importancia, así como también los desafíos que tienen los profesionales en salud mental, debido a los cambios suscitados para salvaguardar la población mundial. El aumento de ansiedad, depresión y estrés, provocaron diferentes reacciones, e interrogantes. El presente estudio adopta el método empírico-analítico, de tipo descriptivo comparativo, con enfoque cuantitativo de corte transversal. El objetivo que se ha trazado es comparar las respuestas de ansiedad, depresión y estrés en dos grupos de estudiantes universitarios, en donde algunos de ellos adquirieron el virus del COVID-19. Se buscó categorizar dichas respuestas y, posteriormente, identificar las similitudes y diferencias entre quienes portaron el virus y quienes no. La muestra estuvo conformada por 459 estudiantes, hombres y mujeres, que reportaron formación universitaria en curso o finalizada en Colombia. Los datos se obtuvieron a partir de la aplicación de dos instrumentos, por un lado, la caracterización sociodemográfica diseñada para fines específicos de la investigación y, por otro, la Escala de Depresión, Ansiedad y Estrés (DASS-21). Los resultados fueron analizados mediante el programa IBM SPSS Statistics 28.0, encontrando que las muestras se distribuyeron normalmente y que las personas que portaron el COVID-19 no presentaron de manera representativa puntajes mayores de depresión, ansiedad y estrés frente a las personas que no tuvieron contagio.
Dos medidas de asimetría basadas en la moda: cálculo y normas interpretativas
Authors: Moral de la Rubia José 
Published: March 2024

Este estudio metodológico de simulación presenta de forma ejemplificada dos medidas de asimetría. Aunque pueden ser útiles cuando la distribución es unimodal, no se reportan en la investigación psicológica. Una es la distancia estandarizada de la media a la moda de Pearson. La otra es la medida robusta de asimetría de Bickel. Se muestra cómo calcular la estimación puntual y de intervalo con el programa R. Además, se calculan intervalos de confianza al 90 %, 95 % y 99 % con 10 000 extracciones con reemplazamiento de muestras-población con distribución normal y diferentes tamaños para disponer de directrices interpretativas de simetría. Se concluye que la regla ∓0.1 no aplica, la moda de Grenander proporciona los intervalos de confianza más eficientes, pero la asimetría de Bickel es la opción con variables ordinales.
Relaciones entre Bienestar Psicológico y Resiliencia en personal de enfermería
Authors: Quiceno Japcy Margarita , Giraldo Montoya Laura Susana , Vinaccia Alpi Stefano 
Published: March 2024

El objetivo del presente estudio fue evaluar las relaciones entre el Bienestar Psicológico y la Resiliencia en 54 empleados de enfermería de un Hospital de la ciudad de Medellín. El diseño del estudio fue descriptivo correlacional de corte transversal. Instrumentos: se empleó la Escala de Resiliencia de Connor-Davidson (CD-RISC 10) y la Escala de Bienestar Psicológico de Ryff. Resultados: se encontró, por un lado, altos niveles de Resiliencia y Bienestar Psicológico en la muestra de estudio y, por otro lado, la Resiliencia tuvo correlaciones positivas con todos los dominios de la escala de Bienestar Psicológico de Ryff. En especial, los dominios de Propósito en la vida y Autonomía tienen un peso significativo sobre la resiliencia. Conclusiones: una resiliencia fortalecida mejora la percepción de bienestar psicológico en el personal de enfermería y una mejor percepción de bienestar psicológico potencia la resiliencia. El tener un propósito claro en la vida y mantener la propia individualidad en diferentes contextos a pesar de las presiones son marcadores positivos para promover la resiliencia en Enfermería y Profesiones Sanitarias.
CCN3/NOV Serum Levels in Non-Alcoholic Fatty Liver Disease (NAFLD) Patients in Comparison with the Healthy Group and their Correlation with TNF-α and IL-6
Authors: Afrisham Reza , Alasvand Ghazal , Jadidi Yasaman , Farrokhi Vida , Fadaei Reza , Alizadeh Shaban , Moradi Nariman 
Published: March 2024

Introduction:
Adipokine irregularity leads to inflammation, endothelial
dysfunction, insulin resistance (IR), and Non-Alcoholic Fatty Liver Disease (NAFLD).
Previous studies linked NOV/CCN3 to obesity, IR, and inflammation, but no research
has explored the connection between CCN3 serum levels and NAFLD.

Methods:
This case-control study assessed CCN3, IL-6, adiponectin, and TNF-α
serum levels in 80 NAFLD patients and 80 controls using ELISA kits. Biochemical
parameters were measured with commercial kits and an auto analyzer.

Results:
NAFLD patients exhibited significantly higher CCN3 (2399.85 ± 744.53 vs.
1712.84 ± 478.19 ng/ml), TNF-α, and IL-6 levels, and lower adiponectin levels
compared to controls (P<0.0001). In the NAFLD group, CCN3 showed positive
correlations with FBG, insulin, HOMA-IR, and TNF-α. Binary logistic regression
analysis revealed increased NAFLD risk in the adjusted model (OR [95% CI] = 1.220
[1.315 –1.131]). A CCN3 cut-off value of 1898.0050 pg/mL differentiated NAFLD
patients from controls with 78.8% sensitivity and 73.2% specificity.

Conclusion:
It was found that elevated CCN3 serum levels directly correlate with NAFLD incidence
and inflammation markers (IL-6 and TNF-α). CCN3 could serve as a potential
biomarker for NAFLD, but further research is needed to validate this finding and
assess its clinical utility.
An Enzyme-responsive Porphyrin Metal-organic Framework Nanosystem for Targeted and Enhanced Synergistic Cancer Photo-chemo Therapy
Authors: Yi Mengqi , Lin Yangxin , Li Yuyang , Xiong Bei , Huang Yunhan , Guo Wei , Lu Bo 
Published: March 2024

Background:
The clinical efficiency of photodynamic therapy (PDT) in combination
with chemotherapy has proven to be a promising strategy for tumor treatment, yet is restricted by
the high glutathione (GSH) concentration at the tumor site and nonspecific drug targeting.

Objective:
The goal of the current research was to create a biocompatible GSH-depleting and tumor-
targeting nanoparticle (denoted as DOX/CA@PCN-224@HA) for the combined photodynamic
and chemo photo-chemo) therapy.

Methods:
The nanoparticles were characterized by transmission electron microscopy (TEM). A
UV-vis spectrophotometer was used to measure the drug loading efficiency (DE) and encapsulation
efficiency (EE). The GSH-depleting ability was measured using Ellman's test. Confocal laser
scan microscopy (CLSM) was used to assess the cellular uptake. MTT was adopted to evaluate
the cytotoxicity of DOX/CA@PCN-224@HA against 4T1 cells.

Results:
The altered PCN-224 showed excellent monodispersing with a dimension of approximately
193 nm ± 2 nm in length and 79 nm ± 3 nm in width. The larger and spindle grid-like structure
of PCN-224 obtains better dual-drug loading ability (DOX: 20.58% ± 2.60%, CA: 21.81% ±
1.98%) compared with other spherical PCN-224 nanoparticles. The ultimate cumulative drug release
rates with hyaluronidase (HAase) were 74% ± 1% (DOX) and 45% ± 2% (CA) after 72 h.
DOX/CA@PCN-224@HA showed GSH-consuming capability, which could improve the PDT effect.
The drug-loaded nanoparticles could accurately target 4T1 cells through biological evaluations.
Moreover, the released DOX and CA display cooperative effects on 4T1 cells in vitro.
DOX/CA@PCN-224@HA nanoparticles showed inhibition against 4T1 cells with an IC50 value of
2.71 μg mL-1.

Conclusion:
This nanosystem displays great potential for tumor-targeted enhanced (photo-chemo)
therapy.
Handwriting Markers for the Onset of Alzheimer’s Disease
Authors: Chernov Yury 
Published: March 2024

Introduction:
Alzheimer's disease has an impact on handwriting (AD). Numerous researchers
reported that fact. Therefore, examining handwriting characteristics could be a useful
way to screen for AD. The aim of the article is to present the reliability and effectiveness of the
AD-HS tool.

Method:
Most of the existing studies examine either linguistic manifestations of writing or certain
motor functions. However, handwriting is a complex of cognitive and motor activities. Since
the influence of AD on handwriting is individual, it is important to analyze the complete set of
handwriting features. The AD-HS instrument is based on this principle. Validation of the AD-HS
instrument for revealing cognitive impairment in AD-diagnosed persons in comparison to the control
group. The study is based on the evaluation of free handwritten texts. AD-HS includes 40
handwriting and 2 linguistic features of handwritten texts. It is based on the standard protocol for
handwriting analysis. The cumulative evaluation of all features builds a quantitative AD-Indicator
(ADI) as a marker of possible AD conditions. The analyzed experiment includes 53 AD-diagnosed
persons and a control group of 192 handwriting specimens from the existing database.

Result:
AD-HS shows a distinct difference in evaluated ADI for the participants (the mean value
equals 0.49) and the control group (the mean value equals 0.28).

Conclusion:
The handwriting marker of AD could be an effective supplement instrument for earlier
screening. It is also useful when traditional biomarkers and neurological tests could not be applied.
AD-HS can accompany therapy as an indication of its effect on a person.
Unlocking the Therapeutic Potentiality of Natural Products in Cancer Therapy: A Recent Update and Current Prospects
Authors: Khurshid Asma , Hussain Rabbia , Farooq Rimsha 
Published: March 2024

:
Cancer is one of the main causes of mortality that affects a large propotion of population
worldwide each year. Traditional and synthetic medications are less successful in cancer treatment.
The deleterious effects of synthetic compounds divert our attention toward the utilization of naturally
derived compounds in current clinical research. The impact of biodiversity on population development
and livelihood represents a wider area of interest that still heavily relies on natural medicines
against the cure of various ailments. Since ancient times, people have been using natural plants because
of their accessibility and economical affordability as a safe therapeutic alternative to traditional
synthetic drugs. Currently, plants are used because of their remarkable properties in the form of staple
drugs. These plants gain huge attention as a safe treatment option with anti-tumor, chemo-protective
and anti-proliferative properties than conventional harmful therapeutics. The secondary metabolites
extracted from medicinal plants lead to the production of innovative therapeutic strategies against
cancer and other diseases. Targeted delivery of pharmaceuticals agents, through chemical and conventional
methods is a significant challenge. The discovery of nano-vectors provides a solution to this
issue with the innovation of plant-based nanoparticles have been manufactured using an ecologically
sound method. Based on the highlights provided, the current review provides updated knowledge on
diverse aspects of medicinal plants including challenges, significance and their role as a potential
therapeutic agent against the treatment of various diseases, especially cancers. This subsequent review
entails and clarifies the benefits of phytochemicals extracted from Asian medicinal plants due to
their imperative values in cancer treatment and other pharmacological targets. The recent discoveries
and findings linked to the understanding of medicinal drugs with significance on wide range of phytochemical
constituents or secondary metabolites are a current attempt to update our knowledge towards
the progress of natural therapeutics novel strategies.
Application of Antioxidants in Curing Respiratory and Pulmonary
Disorders
Authors: Bhardwaj Ittishree , Gupta Reena 
Published: March 2024

Abstract:
Since a couple of decades, respiratory ailments have emerged as a significant public
health issue. Numerous primitive civilizations acknowledged the need to relieve the inflamed airways and nasal passages oxidants are a persistent danger to the lungs since they can be produced
either intracellularly by metabolic processes (such as mitochondrial electron transfer during respiration or during phagocyte activation) or from another source such as tobacco smoking or air pollutants. It is likely to be advantageous to target oxidative stress with antioxidants or increase endogenous antioxidant levels in the treatment of COPD, asthma, and COVID-19. In trials on both human beings and animals, the administration of small antioxidants via the intratracheal, oral, and
vascular routes exhibited only minimal therapeutic potential against short- and long-term oxidative stress. Lipids, proteins, and nucleic acids all respond to oxygen in quick and practical ways.
For the ROS (reactive oxygen species) system to run properly, it requires adequate oxidation-reducing components, like vitamins and antioxidants intake. Numerous nutrients, including vitamins
such as vitamin A, vitamin B etc., minerals (magnesium, zinc, and iron), flavonoids, and fatty
acids, have prominent functions in reducing the likelihood of viral diseases and chronic lung disorders. In this review, the applications of antioxidants in the prevention of respiratory diseases are
discussed along with some reported nutraceuticals being used in respiratory disease and patents.
The applications of antioxidants in preventing and managing respiratory diseases are discussed in
this review, shedding light on the importance of ongoing research in this field. Nutraceuticals,
which combine the benefits of nutrition and pharmaceuticals, are also explored as potential solutions for respiratory health.
Unusual Breast Metastasis from Atypical Lung Carcinoid on 68Ga-DOTATATE
PET/CT
Authors: Okudan Berna , Seven Bedri , Yıldırım Aslıhan , Albayrak Aynur 
Published: March 2024

Background:
Atypical carcinoid (AC) is one of the rarest lung neuroendocrine tumors (NETs) that rarely metastasize to the breast, and only a few cases have
been reported in the literature. Positron emission tomography/computed tomography (PET/CT) with somatostatin analogs (SSAs) labeled with
Gallium-68 (68Ga) now represents the gold standard for diagnosis and management of NETs. A case of an unusual metastasis to the breast from an
AC detected by 68Ga-DOTATATE PET/CT was reported.

Case Presentation:
A 73-year-old woman was presented with a right breast lesion found on mammography screening, which revealed a metastatic neuroendocrine
tumor by histopathological analysis with a tru-cut biopsy. Subsequently, 68Ga-DOTATATE PET/CT imaging performed for the initial evaluation
showed increased radiotracer uptake in the lesion in the right breast as well as the nodular lesion in the middle lobe of the right lung, which was
histologically confirmed to be AC.

Conclusion:
Metastasis of uncommon AC of the lung to the breast is extremely rare. However, it is essential to properly differentiate metastatic tumors from
primary disease due to differences in clinical management and prognosis, and 68Ga-DOTATATE PET/CT is a unique diagnostic tool with the
advantage of whole-body imaging.
Chemical Synthesis, Biological Evaluation, and Cheminformatics Analysis of a Group of Chlorinated Diaryl Sulfonamides: Promising Inhibitors of
Cholesteryl Ester Transfer Protein
Authors: Abu Khalaf Reema , Lafi Ala’a , Hajjo Rima , Al-Sha'er Mahmoud A. 
Published: March 2024

Background:
Hyperlipidemia is characterized by an abnormally elevated serum cholesterol,
triglycerides, or both. The relationship between an elevated level of LDL and cardiovascular
diseases is well-established. Cholesteryl ester transfer protein (CETP) is an enzyme
that moves cholesterol esters and triglycerides between LDL, VLDL, and HDL. CETP inhibition
leads to a reduction in cardiovascular disease by raising HDL and minimizing LDL.

Objective:
This study synthesized ten meta-chlorinated benzene sulfonamides 6a-6j and explored
their structure-activity relationship.

Methods:
The synthesized molecules were characterized using 1H-NMR, 13C-NMR, IR, and
HR-MS. Moreover, cheminformatics analyses included pharmacophore mapping, LibDock
studies, and cheminformatics characterization using 2-dimensional (2D) molecular descriptors
and principal component analysis.

Results:
Based on in vitro functional CETP assays, compounds 6e, 6i, and 6j demonstrated the
strongest inhibitory activities against CETP, reaching 100% inhibition. The inhibitory activity
of compounds 6a-6d and 6f-6h ranged from 47.5% to 96.5% at 10 μM concentration. Pharmacophore
mapping results suggested CETP inhibitory action, while the docking scores and calculated
binding energies predicted favoring binding at the CETP active site. Best-scoring docking
poses predicted critical hydrophobic features corresponding to key interactions with His232 and
Cys13. Cheminformatics analysis using 2D molecular descriptors indicated that the synthesized
compounds span various physicochemical properties and drug-likeness.

Conclusion:
It was found that a chloro moiety at the ortho-position, or a nitro group at the meta
and para-positions, improves the CETP inhibitory activity of synthesized analogs. Computational
studies suggest the formation of stable ligand-protein complexes between compounds 6a-
6j and CETP.

conclusion:
It was found that the presence of a chloro moiety at the ortho position, or the presence of a nitro group at the meta and para positions, improve the CETP inhibitory activity of synthesized analogs. Computational studies suggest the formation of stable ligand -protein complexes between compounds 6a-6j and CETP.