bluuebunny/crossref_metadata_2025_split huggingface dataset:
A road map for the management of a pregnancy complicated by maternal bladder exstrophy
Authors: Hosiani A , Smet M.E. , Nayyar R 
Published: March 2024

AbstractBladder exstrophy (BE) is a congenital genito-urinary malformation where there is a defect in the abdominal wall resulting in a protruding open bladder with exposed mucosa (Resnik R.P. et al. Creasy and Resnik’s maternal-fetal medicine: principles and practice. Elsevier, 2019). Several reconstructive procedures are required to correct the anomalies, resulting in an ileal conduit which is an alternate urinary reservoir reconstructed from the terminal ileum (Madersbacher S, et al. J Urol 169(3):985–90, 2003). We describe the care of a pregnant woman with BE and outline the principles of management of her pregnancy with a multidisciplinary team. Timely pre-operative planning is advised to minimise intraoperative complications in the event of a caesarean section. The woman went on to have an uncomplicated classical caesarean section at term by midline laparotomy with a good outcome for both mother and baby.
Rates and determinants of Rotavirus vaccine uptake among children in Italy: a cross-sectional study within the 2022 OBVIOUS* project
Authors: La Fauci Giusy , Soldà Giorgia , Di Valerio Zeno , Salussolia Aurelia , Montalti Marco , Scognamiglio Francesca , Capodici Angelo , Fantini Maria Pia , Larson Heidi J. , Leask Julie , Gori Davide , Lenzi Jacopo 
Published: March 2024

Abstract
Introduction
The World Health Organization defines rotavirus as among the most severe causes of viral gastroenteritis affecting children under 5 year old. Italy and other European countries do not release disaggregated data on rotavirus vaccination coverage. This study aimed to assess the uptake and drivers of rotavirus vaccination in Italy.

Methods
We administered a survey to 10,000 Italian citizens recruited via an online panel and proportionate to key demographic strata. We examined rotavirus vaccine uptake among parents whose youngest child was aged 6 weeks to 4 years, their sociodemographic characteristics, their beliefs about vaccine administration, and who recommended the rotavirus vaccination.

Results
A total of 711 respondents met the inclusion criteria for the rotavirus vaccine questionnaire. The uptake was estimated at 60.3% nationwide (66.4% among mothers and 50.2% among fathers). Being a mother and living in cities/suburbs was significantly associated with a higher likelihood of vaccine uptake, while fathers were more likely to be uncertain of their children’s vaccine status. Living in Central Italy and having friends/relatives opposed to vaccination were found to be significantly associated with a lower likelihood of vaccine uptake, while parents’ education level and children’s demographics were not found to correlate with any outcomes. In 90.3% of cases, the rotavirus vaccination was recalled as being recommended by a paediatrician.

Conclusions
Consistent collection of behavioural preferences and socioeconomic characteristics of recipients of rotavirus vaccine campaigns, their epidemiological information, cost-benefit, and national policy data are crucial for designing effective vaccination strategies in Italy and other European countries with similar social profiles to reach the target uptake.
Clinical study of electroacupuncture on the recovery of gastrointestinal dysfunction after laparoscopic surgery for gastrointestinal cancer - study protocol for a randomized controlled trial
Authors: Chung Shuet Ling , Li Wen , Wang Qiuyue , Qiu Xiaofeng , Tang Yuncheng , Hu Sheng , Wu Huangan , Jin Zhu 
Published: March 2024

Abstract
Background
Gastrointestinal dysfunction is one of the common complaints for patient post-surgery. Acupuncture has been employed to improve gastrointestinal function and sleeping quality and has confirmed clinical efficacy for emotional problems. This study aims to evaluate the clinical effect of electroacupuncture for postoperative rapid recovery.

Methods
This study design is a two-arm, parallel, double-blinded randomized controlled trial. 104 subjects, aged from 40 to 89 years old, diagnosed with gastrointestinal cancer undergoing laparoscopic surgery, will be divided into Interventional Group and Control Group. Patients of both groups receive perioperative care under the guidance of ERAS guidance. The Interventional Group receives electroacupuncture treatment starting from the first day post-surgery for a consecutive 5 days, whereas the Control Group receives placebo electroacupuncture treatment. The primary outcome will be the first flatus time whereas the secondary outcomes will be the first sign of borborygmus, recovery of defecation, laboratory tests and questionnaires including Self-rating anxiety scale, Ford Insomnia Response to Stress Test, TCM rating scale of Gastrointestinal symptoms and Gastrointestinal Symptoms Rating Scales.

Discussion
This study aims to provide timely intervention for post-laparoscopic patients with gastrointestinal tumour using the ERAS concept combined with electroacupuncture, observe the efficacy of this therapy in treating PGID, and contribute reliable scientific evidence for postoperative rapid recovery.

Trial registration
Chictr.org.cn Identifier: ChiCTR2300078710. Registered on 15th December 2023.
Pilot study of the effectiveness of a telehealth group for improving peer relationships for adolescents with neurofibromatosis type 1
Authors: Glad Danielle M. , Pardej Sara K. , Olszewski Ellen , Klein-Tasman Bonita P. 
Published: March 2024

Abstract
Background
Interventions for social difficulties have not been investigated in the neurofibromatosis type 1 (NF1) population despite observations of elevated rates of social difficulties. In this pilot study, the effectiveness of a 14-week telehealth PEERS® intervention with nineteen adolescents with NF1 (Mage=13.79 years, SD = 1.32) with social skills difficulties was examined. Measures of social outcomes were completed at three timepoints (before, immediately after, and at 14-week follow-up).

Results
Caregiver-reported social-emotional skills, social impairment, caregiver-reported number of adolescent get-togethers, and teen social knowledge showed significant improvement following the intervention.

Conclusions
The PEERS® intervention is promising to support the social and friendship skills of adolescents with NF1 who have social difficulties.
Functionally-instructed modifiers of response to ATR inhibition in experimental glioma
Authors: Walter Bianca , Hirsch Sophie , Kuhlburger Laurence , Stahl Aaron , Schnabel Leonard , Wisser Silas , Haeusser Lara A. , Tsiami Foteini , Plöger Sarah , Aghaallaei Narges , Dick Advaita M , Skokowa Julia , Schmees Christian , Templin Markus , Schenke-Layland Katja , Tatagiba Marcos , Nahnsen Sven , Merk Daniel J. , Tabatabai Ghazaleh 
Published: March 2024

Abstract
Background
The DNA damage response (DDR) is a physiological network preventing malignant transformation, e.g. by halting cell cycle progression upon DNA damage detection and promoting DNA repair. Glioblastoma are incurable primary tumors of the nervous system and DDR dysregulation contributes to acquired treatment resistance. Therefore, DDR targeting is a promising therapeutic anti-glioma strategy. Here, we investigated Ataxia telangiectasia and Rad3 related (ATR) inhibition (ATRi) and functionally-instructed combination therapies involving ATRi in experimental glioma.

Methods
We used acute cytotoxicity to identify treatment efficacy as well as RNAseq and DigiWest protein profiling to characterize ATRi-induced modulations within the molecular network in glioma cells. Genome-wide CRISPR/Cas9 functional genomic screens and subsequent validation with functionally-instructed compounds and selected shRNA-based silencing were employed to discover and investigate molecular targets modifying response to ATRi in glioma cell lines in vitro, in primary cultures ex vivo and in zebrafish and murine models in vivo.

Results
ATRi monotherapy displays anti-glioma efficacy in vitro and ex vivo and modulates the molecular network. We discovered molecular targets by genome-wide CRISPR/Cas9 loss-of-function and activation screens that enhance therapeutic ATRi effects. We validated selected druggable targets by a customized drug library and functional assays in vitro, ex vivo and in vivo.

Conclusion
In conclusion, our study leads to the identification of novel combination therapies involving ATRi that could inform future preclinical studies and early phase clinical trials.
Neutrophil lncRNA ZNF100-6:2 is a potential diagnostic marker for active pulmonary tuberculosis
Authors: Huang Shuying , Kang Xiuhua , Zeng Zhenguo , Zhang Qilong , Huang Zikun , Luo Kaihang , Yao Qinqin , Chen Bing , Qing Cheng 
Published: March 2024

AbstractActive pulmonary tuberculosis (PTB) poses challenges in rapid diagnosis within complex clinical conditions. Given the close association between neutrophils and tuberculosis, we explored differentially expressed long non-coding RNAs (lncRNAs) in neutrophils as potential molecular markers for diagnosing active PTB. We employed a gene microarray to screen for lncRNA alterations in neutrophil samples from three patients with active PTB and three healthy controls. The results revealed differential expression of 1457 lncRNAs between the two groups, with 916 lncRNAs upregulated and 541 lncRNAs down-regulated in tuberculosis patients. Subsequent validation tests demonstrated down-regulation of lncRNA ZNF100-6:2 in patients with active PTB, which was restored following anti-tuberculosis treatment. Our findings further indicated a high diagnostic potential for lncRNA ZNF100-6:2, as evidenced by an area under the receiver operating characteristic (ROC) curve of 0.9796 (95% confidence interval: 0.9479 to 1.000; P < 0.0001). This study proposes lncRNA ZNF100-6:2 as a promising and novel diagnostic biomarker for active PTB.
Association between 3D membranous urethral parameters and urinary continence recovery after RARP
Authors: Wang Ming , Deng Ruiqi , Wang Lei , Li Mingzhao , Zeng Tao , Na Yanqun , Gu Di 
Published: March 2024

Abstract
Objectives
To evaluate whether the urinary continence (UC) recovery after robotic-assisted radical prostatectomy (RARP) relates to the membranous urethral length (MUL) and the membranous urethral complex volume (MUV).

Materials and methods
120 patients who underwent RARP were enrolled according to the different times of UC recovery and examined using prostate magnetic resonance imaging (MRI) before surgery. The membranous urethral (MU) parameters were measured using the three-Dimensional (3D) model reconstructed by holographic technology, such as total MUV (tMUV), exposed MUV (eMUV), full MUL (fMUL) and exposed MUL (eMUL). Statistical software SPSS 26.0 was used to analyze the data and compare the MU parameters and baseline data in different groups.

Results
Patients with larger tMUV (p = 0.038), eMUV (p = 0.003), longer fMUL (p = 0.025), eMUL (p = 0.044) had better UC after removal of the catheter, and eMUV (OR = 1.002, 95%CI = 1.001–1.004, p = 0.004) was a predictor; the patients with younger age (p = 0.021), lower VPSS score (p = 0.004) and larger eMUV (p = 0.012) and longer eMUL (p = 0.049) had better UC recovery one month after RARP while eMUV (OR = 1.002, 95% CI = 1.000–1.003, p = 0.008) and VPSS score (OR = 0.886, 95% CI = 0.806–0.973, p = 0.011) were independent risk factors; The patients with younger age (p = 0.018), larger tMUV (p = 0.029), eMUV (p = 0.016) had better UC recovery three months after RARP. eMUV (OR = 1.002, 95% CI = 1.000–1.004, p = 0.042) and age (OR = 0.904, 95% CI = 0.818–0.998, p = 0.046) were independent risk factors.

Conclusion
This clinical study shows that patients with larger MUV and longer MUL can return to UC earlier after surgery. Among that, eMUV is a better predictor.
Treatment modalities for granulomatous mastitis, seeking the most appropriate treatment with the least recurrence rate: a systematic review and meta-analysis
Authors: Sarmadian Roham , Safi Fatemeh , Sarmadian Hossein , Shokrpour Maryam , Almasi-Hashiani Amir 
Published: March 2024

Abstract
Background
Granulomatous mastitis (GM) is a rare, benign, inflammatory breast disease with an unknown etiology that predominantly affects women of reproductive age. The definitive treatment of GM is currently controversial; an appropriate therapeutic strategy has yet to be identified, and the disease’s high recurrence rate remains. This study aims to determine the recurrence rate for each GM treatment strategy to identify the most appropriate treatment modality.

Methods
The search for relevant articles was undertaken using three international databases, including Medline, Scopus, and Web of Science. Articles published in English until the end of 2021 evaluating the recurrence rate of GM were included. Using Stata 13.0, the pooled incidence and 95% confidence interval (CI) for the recurrence rate were determined.

Results
Sixty-five eligible studies were included in our study. The recurrence rates of systemic steroid use, topical steroid use, antibiotic use, methotrexate use, observation, drainage, excision, antibiotic use and surgery, steroid use and surgery, antibiotic and steroid use, methotrexate and steroid use were 24% (95% CI: 21–27%), 11% (95% CI: 6–21%), 18% (95% CI: 14–22%), 13% (95% CI: 7–22%), 11% (95% CI: 7–17%), 65% (95% CI: 50–78%), 13% (95% CI: 10–16%), 23% (95% CI: 14–36%), 7% (95% CI: 5–11%), 11% (95% CI: 6–18%), and 4% (95% CI: 2–8%), respectively. Drainage had the highest recurrence rate, while combined methotrexate and steroid treatment had the lowest rate.

Conclusion
The optimal treatment strategy for GM depends on the disease’s severity, consequences, and the patient's features. The study results indicate that combination therapy is preferable for minimizing the risk of relapse and reducing treatment complications.
The experience of felt presence in a general population sample
Authors: Brederoo Sanne G. , Alderson-Day Ben , de Boer Janna N. , Linszen Mascha M. J. , Sommer Iris E. C. 
Published: March 2024

SummaryFelt presence is a widely occurring experience, but remains under-recognised in clinical and research practice. To contribute to a wider recognition of the phenomenon, we aimed to assess the presentation of felt presence in a large population sample (n = 10 447) and explore its relation to key risk factors for psychosis. In our sample 1.6% reported experiencing felt presence in the past month. Felt presence was associated with visual and tactile hallucinations and delusion-like thinking; it was also associated with past occurrence of adverse events, loneliness and poor sleep. The occurrence of felt presence may function as a marker for general hallucination proneness.
Anterior cruciate ligament injury should not be considered a contraindication for medial unicompartmental knee arthroplasty: Finite element analysis
Authors: Ou Deyan , Ye Yongqing , Pan Jingwei , Huang Yu , Kuang Haisheng , Tang Shilin , Huang Richao , Mo Yongxin , Pan Shixin 
Published: March 2024

Purpose
The research objective of this study is to use finite element analysis to investigate the impact of anterior cruciate ligament (ACL) injury on medial unicompartmental knee arthroplasty (UKA) and explore whether patients with ACL injuries can undergo UKA.

Methods
Based on the morphology of the ACL, models of ACL with diameters ranging from 1 to 10mm are created. Finite element models of UKA include ACL absence and ACLs with different diameters. After creating a complete finite element model and validating it, four different types of loads are applied to the knee joint. Statistical analysis is conducted to assess the stress variations in the knee joint structure.

Results
A total of 11 finite element models of UKA were established. Regarding the stress on the ACL, as the diameter of the ACL increased, when a vertical load of 750N was applied to the femur, combined with an anterior tibial load of 105N, the stress on the ACL increased from 2.61 MPa to 4.62 MPa, representing a 77.05% increase. Regarding the equivalent stress on the polyethylene gasket, a notable high stress change was observed. The stress on the gasket remained between 12.68 MPa and 14.33 MPa in all models. the stress on the gasket demonstrated a decreasing trend. The equivalent stress in the lateral meniscus and lateral femoral cartilage decreases, reducing from the maximum stress of 4.71 MPa to 2.61 MPa, with a mean value of 3.73 MPa. This represents a reduction of 44.72%, and the statistical significance is (P < 0.05). However, under the other three loads, there was no significant statistical significance (P > 0.05).

Conclusion
This study suggests that the integrity of the ACL plays a protective role in performing medial UKA. However, this protective effect is limited when performing medial UKA. When the knee joint only has varying degrees of ACL injury, even ACL rupture, and the remaining structures of the knee joint are intact with anterior-posterior stability in the knee joint, it should not be considered a contraindication for medial UKA.
Neural networks reliability for feedback processing.
Authors: Ermakova Anastasia 
Published: March 2024

Nowadays neural networks are a powerful instrument involved in industry, medicine, and science. AI takes part in graphics design, medicine, natural text processing, video recognition, speech generation, autonomous driving, and numerous other fields. Might AI completely replace a human workforce in specific areas? Or does it stay as a mighty instrument to facilitate task execution?
Firstly, I have analyzed CNN and RNN neural network structure.
Secondly, I have described an experiment to process feedback with AI to check its reliability
Farmersâ€™ Perceptions and Behavior which Affecting the Adoption Rate of KUB Chickens
Authors: Syarifah Iif , Sirajuddin Sitti Nurani , Baba Syahdar , Najib Mukhamad 
Published: March 2024

KUB chicken as a superior breed produced by Indonesian Agency for Agricultural Instrument Standardization (IAAIS) becomes one of the solutions in an effort to increase the need for animal protein. KUB chicken breeds have been successfully disseminated to all provinces in Indonesia. Thus the rate of adoption and behavior of breeders in maintaining the sustainability of KUB chicken rearing needs to be analyzed Â because the breeds that are disseminated may not be successfully developed in a certain area. This research will collaborate between the two theories; "Theory of Planned Behavior" (TPB) and "Technology Acceptance Model" (TAM). It was conducted in June 2022 in the City of Salatiga, Semarang and Magelang, Central Java Province. The determination of the research location was based on the consideration that there was a KUB chicken breeders group that already had a KUB chicken breeder association called AnaKUB (KUB Chicken Breeders Association) and a breeding population that met the sampling requirements. The purpose of this research was to analyze the perception factors and breeders behavior that affect the adoption rate of KUB Chicken Technology in Central Java Province, Indonesia. ). The combined results of path analysis (path) and regression analysis on the Structural Equation Modeling (SEM) technique, it can be concluded that perceived benefits (25.3%), ease of raising KUB chickens (23.9%), attitudes (21.2%), subjective norms (16.7%) and perceptions of control behavior (17.3%) have a positive effect on the intention to adopt KUB chickens. The perceived benefits (45.8%) and the perceived ease of raising KUB chickens (50.1%) have a very positive effect on the attitude variable of the farmer. Important people including family members have an important role in supporting the maintenance of KUB chickens, while extension workers have not contributed much in supporting breeders to adopt KUB chickens. Collaboration of two theories has a mutually influencing relationship, especially towards attitudes and intentions to adopt KUB chickens which have a positive effect on the adoption rate. The adoption rate of KUB chicken is 3.32 (66.40%), this shows that the adoption rate of breeders in the Central Java region, is classified as high adoption.
Embryo Production and Development from Superovulated Donors in Double-Muscled Cattle and Their Crosses
Authors: Irma Irma Irma , Rasad Siti Darodjah , Hilmia Nena , Sumantri Cece 
Published: March 2024

Belgian Blue was introduced in Indonesia to increase the biodiversity of livestock genetic resources. Â Belgian Blue was crossed with Ongole grade to increase the productivity of local cattle.Â Therefore, this study evaluates reproduction traits, especially the response to superovulation, embryonic development, and quality of Belgian Blue, Ongole grade, and their crosses.Â Estrous was synchronized with intravaginal progesterone Cue-Mate before artificial insemination (AI).Â Superovulation was performed with Follicle Stimulating Hormone (FSH) intramuscularly with non-surgical embryo flushing. Â In addition, embryo quality was assessed microscopically according to the International Embryo Transfer Society (IETS) criteria.Â The study was performed in a quasi-experimental design, and data were analyzed with an analysis of variance.Â After superovulation, oocytes/embryos were obtained from all donor breeds.Â Oocyte and embryo production from Ongole grade and Belgian Blue differed at 11.83Â±1.91 and 4.86Â±1.33, respectively, P0.05 (meanÂ±SEM).Â In addition, there are differences in recovery rate (89.63% vs. 75.35%) and fertilization rate (77.35% vs. 68.22%) between Ongole grade and Belgian Blue, respectively (P0.05).Â There is no difference in embryo development quality and proportion of transferable embryos between Ongole grade, Belgian Blue, and their crosses.Â This study concluded that the cross-bred Belgian Blue x Ongole donor had identical oocyte and embryo production, recovery rate, fertilization rate, and degenerative embryos compared to its purebred.
A Case Study of Biology Teaching Practices in Croatian Primary Schools
Authors: Mirosavljević Ana , Bognar Branko , Sablić Marija 
Published: March 2024

Abstract
The aim of this case study is to present the most frequent teaching methods used by biology teachers in the Republic of Croatia, based on the observations made during biology class and the teachers’ statements. The study included six distinguished primary school biology teachers, along with their seventh-grade classes. The data comprised an interview with each teacher and twelve class observations. The results show that biology education in the Croatian educational system is mostly traditional, whereby students mostly practice listening to the teacher (34%) and answering the questions (18%). In summary, the majority of teaching consists of teachers presenting the content materials and asking questions or engaging students in specific individual or group activities. The present study has determined a lack of student questions and class discussions. Additionally, the nature of teachers’ questions does not encourage students to think and provide extensive answers. For this reason, the study suggests that teachers encourage students to ask questions and organize teaching activities in ways which will contribute to more class activity and deep learning of students. Despite some acknowledged limitations, the results of this study can contribute to a better understanding of the teachers’ experiences in authentic science classrooms, in specific contexts.