bluuebunny/crossref_metadata_2025_split huggingface dataset:
FASCINATION AND ITS RELATION TO EGO–SELF STATES
Authors: Humphreys Nicholas 
Published: November 2006

ABSTRACT
This paper focuses on experiences of fascination in the transference and countertransference. It suggests that fascination arises through the projection of an internal state where an unconscious content has intruded into the ego. Using clinical examples, it outlines a distinction between fascination as a facilitative process in psychotherapy, and fascination indicative of defence and destructiveness. In the former, fascination is linked to an exploration of symbols and their subsequent release of meaning. In the latter, fascination is considered as an end in itself: a powerfully persuasive fantasy that reality can be dispensed with. The Analytical Psychology concept of the ego‐self relationship is briefly outlined with a view to establishing a theoretical base from which to support this distinction, and to suggest that the ego's fascination is elicited through an unfolding archetypal process. The conclusion summarizes these findings and their implications for clinical work.Love looks not with the eyes, but with the mind; And therefore is wing'd Cupid painted blind. (Shakespeare, A Midsummer Night's Dream)
HUMAN LONGINGS AND MASCULINE TERRORS: MASCULINITY AND SEPARATION FROM MOTHER
Authors: Wieland Christina 
Published: November 2006

ABSTRACT
The paper explores two literary texts ‐ Dostoevsky's novel Crime and Punishment and Euripides’play Bacchae ‐ from the point of view of immature masculinity and the catastrophe that can follow if the boy fails to achieve a genuine separation from the maternal object. The author examines the masculine anxieties and defences that arise when the boy fails to work through the Oedipus complex and instead retreats to a dyadic relation with mother which excludes the father. This retreat involves a denial of reality and the creation of a paranoid world in which his own wishes to take possession of mother can be experienced by him as an intrusion by the mother into his own masculine identity and ultimately as castration by the mother. Attempts to resolve this threat to masculinity include the use of anal defences and tyrannical states of mind in the creation of a pseudo‐masculinity.The movement into the male Oedipus complex necessarily involves a psychological state in which the externality of the oedipal‐object mother is continually in danger of being blurred by the shadow cast by the pre‐oedipal mother. (Thomas Ogden 1992)
THE QUESTION OF THE FATHER AND SEXUAL DISTURBANCES IN PSYCHOSIS
Authors: O'Loughlin Elizabeth 
Published: November 2006

ABSTRACT
The first half of this paper attempts to track and to elaborate Freud's thesis on the mechanism proper to psychosis with particular attention paid to the case of Schreber. It is written emphasizing that Freud was only at the initial stages of his work on the function of the father and that this led to the stumbling blocks he encountered and left him dissatisfied with his work. The second half of the paper looks at the way in which Jacques Lacan took up Freud's work. It looks at how he used it to understand the structure of psychosis in a new way, giving the specific problems that arise in psychosis a central place in the practice of psychoanalysis.How is that one day life is orderly and you are content, a little cynical perhaps, but on the whole just so, and then without warning you find the solid floor is a trapdoor and you are now in another place whose geography is uncertain and whose customs are strange?… We who were fluent find life is a foreign language. (Jeanette Winterson 1987, back cover)
Tuberin Nuclear Localization Can Be Regulated by Phosphorylation of Its Carboxyl Terminus
Authors: York Brian , Lou Dingyuan , Noonan Daniel J. 
Published: November 2006

Abstract
Tuberin, the tuberous sclerosis 2 (TSC2) gene product, has been identified as a tumor suppressor protein genetically implicated in the pathology of tuberous sclerosis and the female-specific lung disease lymphangioleiomyomatosis. Tuberin and its predominant cytoplasmic binding partner hamartin have been shown to complex with a variety of intracellular signaling regulators and affect the processes of protein translation, cellular proliferation, cellular migration, and cellular transcription. In previous studies, we have presented evidence for tuberin binding to the calcium-dependent intracellular signaling protein calmodulin (CaM), overlap of tuberin CaM binding domain with a binding domain for estrogen receptor α, and the phosphorylation-associated nuclear localization of tuberin. In the study presented here, we expand our findings on the mechanism of tuberin nuclear localization to show that the CaM-estrogen receptor-α binding domain of tuberin can also serve as a tuberin nuclear localization sequence. Furthermore, we identify an Akt/p90 ribosomal S6 kinase-1 phosphorylation site within the carboxyl terminus of tuberin that can regulate tuberin nuclear localization and significantly affect the ability of tuberin to modulate estrogen genomic signaling events. These findings suggest a link between tuberin nuclear localization and a variety of intracellular signaling events that have direct implications with respect to the role of tuberin in the pathology of tuberous sclerosis and lymphangioleiomyomatosis. (Mol Cancer Res 2006;4(11):885–97)
Monthly Climatologies of Oceanic Friction Velocity Cubed
Authors: Klinger Barry A. , Huang Bohua , Kirtman Ben , Schopf Paul , Wang Jiande 
Published: November 2006

Abstract
Different measures of wind influence the ocean in different ways. In particular, the time-averaged mixed layer turbulent energy production rate is proportional to 〈u3*〉, where u* is the “oceanic friction velocity” that is based on wind stress. Estimating 〈u3*〉 from monthly averages of wind stress or wind speed may introduce large biases due to the day-to-day variability of the direction and magnitude of the wind. The authors create monthly climatologies of 〈u3*〉 from daily wind stress measurements obtained from the Goddard Satellite-based Surface Turbulent Fluxes version 2 (GSSTF2; based on satellite microwave measurements), the Quick Scatterometer (QuikSCAT; based on satellite scatterometry measurements), and the National Centers for Environmental Prediction (NCEP) reanalysis wind. The differences among zonal averages of these climatologies and of a similar climatology based on the da Silva version of the Comprehensive Ocean–Atmosphere Data Set (COADS) have a complex dependence on latitude. These differences are typically 10%–30% of the climatological values. The GSSTF2 data confirm that 〈u3*〉 is much larger than estimates from monthly averaged wind stress or wind speed, especially outside the Tropics.
Stratosphere–Troposphere Coupling in a Relatively Simple AGCM: Impact of the Seasonal Cycle
Authors: Kushner Paul J. , Polvani Lorenzo M. 
Published: November 2006

Abstract
The seasonal time dependence of the tropospheric circulation response to polar stratospheric cooling in a simple atmospheric general circulation model is investigated. When the model is run without a seasonal cycle, polar stratospheric cooling induces a positive annular-mode response in the troposphere that takes a remarkably long time—several hundred days—to fully equilibrate. One is thus led to ask whether the tropospheric response would survive in the presence of a seasonal cycle. When a seasonal cycle is introduced into the model stratosphere, the tropospheric response appears with a distinct time lag with respect to the stratospheric cooling, but, in the long-term mean, the pattern of the wind response is very similar to the one that results from stratospheric forcing in the absence of a seasonal cycle.
Fixation de toluène dans une montmorillonite-Cu(II)
Authors: Saehr D. , Walter D. , Wey R. 
Published: November 2006

RésuméLa fixation du toluène et sa polymérisation dans les espaces interfoliaires d'une montmorillonite-Cu(II) au cours de cycles de déshydratation, adsorption, désorption de l'excès de réactif et réhydratation, ont été étudiées. Elles ont été suivies au moyen de diverses méthodes d'analyse (thermogravimétrie, radiocristallographie et spectrophotométrie d'absorption infrarouge). Les résultats rappellent ceux obtenus lors de l'étude du système montmorillonite-Cu(II)-benzène. Ainsi, la fixation du toluène s'effectue selon deux réactions, correspondant l'une à l'adsorption d'une molécule de toluène, l-autre à celle de trois molécules de toluène par ion Cu2+. Toutefois, l'affinité du toluène pour la montmorillonite est supérieure à celle du benzène.
Genesis of the Tirschenreuth kaolin deposit in Germany compared with the Kohdachi kaolin deposit in Japan
Authors: Kitagawa R. , Köster H. M. 
Published: November 2006

AbstractThe mineralogical and geochemical characteristics of the Tirschenreuth and Kohdachi kaolin deposits, which both occur in granite, are compared and the genesis of the deposits discussed. The Tirschenreuth deposit (Rappauf pit) is considered to have formed by weathering because: (i) the kaolinite has formed by the alteration of plagioclase and biotite, whereas microcline and muscovite are unaltered; (ii) the kaolin body has a very homogeneous composition and alteration zones cannot be recognized; (iii) there has been no addition of trace elements from sources other than plagioclase and biotite in the parent rock; (iv) particle-size distribution shows that the kaolinite crystals grew under uniform physical conditions; (v) quartz grains have smooth surfaces.The Kohdachi deposit contains many clay veins and three alteration zones: (i) halloysite with weak silicification; (ii) halloysite-kaolinite; (iii) kaolinite. Many large dissolution pits were observed by SEM on the surface of quartz crystals from the kaolin zone. Silicification, precipitation of goethite at the border of zones (ii) and (iii), and dissolution of quartz in different areas of the deposit indicate a variable pH within a distance of <100 m. The Cu and Li contents in the <2 µm fractions of the Kohdachi kaolin samples are markedly higher than those at Tirschenreuth. From hydrogen isotopic analysis, the formation temperature of the Kohdachi kaolinite may be roughly estimated at 70–150°C. It is suggested that the Kohdachi deposit formed by hydrothermal alteration.
Practical determination of allophane and synthetic alumina and iron oxide gels by X-ray diffraction
Authors: Ruiz Cruz M. D. , Moreno Real L. 
Published: November 2006

AbstractX-ray diffraction methods are effective and practical for the quantitative analysis of the often forgotten amorphous material phase in sediments. The method reported is simple, employing normal oriented samples, and quartz or fluorite as a diluent. However, special care must be taken to prepare the samples properly, to ensure optimum conditions for diffraction, and to measure accurately the scattering bands.
A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance
Authors: Loebstein Ronen , Dvoskin Ilana , Halkin Hillel , Vecsler Manuela , Lubetsky Aharon , Rechavi Gideon , Amariglio Ninette , Cohen Yoram , Ken-Dror Gie , Almog Shlomo , Gak Eva 
Published: November 2006

Abstract
CYP2C9 and VKORC1 genetic variants are associated with low and intermediate warfarin dose requirements, but markers of high doses are less well characterized. We analyzed the VKORC1 coding sequence and known CYP2C9 and VKORC1 polymorphisms in 15 selected warfarin-resistant (dose, 80 to 185 mg/wk) and 8 warfarin-sensitive patients (7 to 13 mg/wk) and 99 unselected controls (8 to 105 mg/wk). We identified a coding VKORC1 Asp36Tyr polymorphism in 7 of 15 resistant compared with 0 of 8 sensitive patients (P = .026) Carriers of Asp36Tyr in the control group (8 of 99) required significantly higher warfarin doses of 80.9 ± 10.1 mg/wk compared with 42.7 ± 7.5 mg/wk in noncarriers (F = 9.79, P = .002). Asp36Tyr was significantly associated with doses of more than 70 mg/wk (odds ratio, 13.0; 95% confidence limit, 1.3 to 124.2), while doses of 20 to 70 mg/wk were associated with Asp36Tyr (partial r2 = .11; P = .004), CYP2C9*2 and *3 (r2 = .08; P = .01), and VKORC1*2 and *3 markers (r2 = .05; P = .05). All Asp36Tyr carriers also had VKORC1*1 tag–single nucleotide polymorphisms (tag-SNPs) indicating a new haplotype. Asp36Tyr was common in Jewish ethnic groups of Ethiopian (15%) and Ashkenazi (4%) origin. We suggest that Asp36Tyr is a new marker of the high end of the warfarin dosing range.
mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets
Authors: Weyrich Andrew S. , Denis Melvin M. , Schwertz Hansjorg , Tolley Neal D. , Foulks Jason , Spencer Eliott , Kraiss Larry W. , Albertine Kurt H. , McIntyre Thomas M. , Zimmerman Guy A. 
Published: November 2006

AbstractNew activities of human platelets continue to emerge. One unexpected response is new synthesis of proteins from previously transcribed RNAs in response to activating signals. We previously reported that activated human platelets synthesize B-cell lymphoma-3 (Bcl-3) under translational control by mammalian target of rapamycin (mTOR). Characterization of the ontogeny and distribution of the mTOR signaling pathway in CD34+ stem cell–derived megakaryocytes now demonstrates that they transfer this regulatory system to developing proplatelets. We also found that Bcl-3 is required for condensation of fibrin by activated platelets, demonstrating functional significance for mTOR-regulated synthesis of the protein. Inhibition of mTOR by rapamycin blocks clot retraction by human platelets. Platelets from wild-type mice synthesize Bcl-3 in response to activation, as do human platelets, and platelets from mice with targeted deletion of Bcl-3 have defective retraction of fibrin in platelet-fibrin clots mimicking treatment of human platelets with rapamycin. In contrast, overexpression of Bcl-3 in a surrogate cell line enhanced clot retraction. These studies identify new features of post-transcriptional gene regulation and signal-dependant protein synthesis in activated platelets that may contribute to thrombus and wound remodeling and suggest that posttranscriptional pathways are targets for molecular intervention in thrombotic disorders.
Using local gene expression similarities to discover regulatory binding site modules
Authors: Wilczyński Bartek , Hvidsten Torgeir R , Kryshtafovych Andriy , Tiuryn Jerzy , Komorowski Jan , Fidelis Krzysztof 
Published: November 2006

Abstract

Background
We present an approach designed to identify gene regulation patterns using sequence and expression data collected for Saccharomyces cerevisae. Our main goal is to relate the combinations of transcription factor binding sites (also referred to as binding site modules) identified in gene promoters to the expression of these genes. The novel aspects include local expression similarity clustering and an exact IF-THEN rule inference algorithm. We also provide a method of rule generalization to include genes with unknown expression profiles.

Results
We have implemented the proposed framework and tested it on publicly available datasets from yeast S. cerevisae. The testing procedure consists of thorough statistical analyses of the groups of genes matching the rules we infer from expression data against known sets of co-regulated genes. For this purpose we have used published ChIP-Chip data and Gene Ontology annotations. In order to make these tests more objective we compare our results with recently published similar studies.

Conclusion
Results we obtain show that local expression similarity clustering greatly enhances overall quality of the derived rules, both in terms of enrichment of Gene Ontology functional annotation and coherence with ChIP-Chip binding data. Our approach thus provides reliable hypotheses on co-regulation that can be experimentally verified. An important feature of the method is its reliance only on widely accessible sequence and expression data. The same procedure can be easily applied to other microbial organisms.
Volume measures for linkage disequilibrium
Authors: Chen Yuguo , Lin Chia-Ho , Sabatti Chiara 
Published: November 2006

Abstract

Background
Defining measures of linkage disequilibrium (LD) that have good small sample properties and are applicable to multiallelic markers poses some challenges. The potential of volume measures in this context has been noted before, but their use has been hampered by computational challenges.

Results
We design a sequential importance sampling algorithm to evaluate volume measures on I × J tables. The algorithm is implemented in a C routine as a complement to exhaustive enumeration. We make the C code available as open source. We achieve fast and accurate evaluation of volume measures in two dimensional tables.

Conclusion
Applying our code to simulated and real datasets reinforces the belief that volume measures are a very useful tool for LD evaluation: they are not inflated in small samples, their definition encompasses multiallelic markers, and they can be computed with appreciable speed.
Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?
Authors: Birkholtz Lyn-Marie , Bastien Olivier , Wells Gordon , Grando Delphine , Joubert Fourie , Kasam Vinod , Zimmermann Marc , Ortet Philippe , Jacq Nicolas , Saïdani Nadia , Roy Sylvaine , Hofmann-Apitius Martin , Breton Vincent , Louw Abraham I , Maréchal Eric 
Published: November 2006

Abstract
The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term, by the necessity to predict and characterize new biological targets and new drugs. Biological targets are sought in a biological space designed from the genomic data from Plasmodium falciparum, but using also the millions of genomic data from other species. Drug candidates are sought in a chemical space containing the millions of small molecules stored in public and private chemolibraries. Data management should, therefore, be as reliable and versatile as possible. In this context, five aspects of the organization and mining of malaria genomic and post-genomic data were examined: 1) the comparison of protein sequences including compositionally atypical malaria sequences, 2) the high throughput reconstruction of molecular phylogenies, 3) the representation of biological processes, particularly metabolic pathways, 4) the versatile methods to integrate genomic data, biological representations and functional profiling obtained from X-omic experiments after drug treatments and 5) the determination and prediction of protein structures and their molecular docking with drug candidate structures. Recent progress towards a grid-enabled chemogenomic knowledge space is discussed.
P-type Na+/K+-ATPase and V-type H+-ATPase expression patterns in the osmoregulatory organs of larval and adult mosquitoAedes aegypti
Authors: Patrick Marjorie L. , Aimanova Karlygash , Sanders Heather R. , Gill Sarjeet S. 
Published: November 2006

SUMMARYThis study describes the expression patterns of P-type Na+/K+-ATPase and V-type H+-ATPase in the larval and adult forms of the mosquito Aedes aegypti and provides insight into their relative importance in ion transport function of key osmoregulatory organs. RT-PCR assays indicate that, at the level of the gene,both ATPases are expressed in all of the osmoregulatory tissues of larvae(midgut, Malpighian tubules, rectum and anal papillae) and adults (stomach,Malpighian tubules, anterior hindgut and rectum). Immunohistochemical studies determined that both ATPases are present in high levels in all the relevant organs, with the exception of the larval rectum (P-type Na+/K+-ATPase only). In larval gastric caeca, ATPase location corresponds to the secretory (basal P-type Na+/K+-ATPase, apical V-type H+-ATPase) and ion-transporting (V-type H+-ATPase on both membranes) regions as previously described. The two ATPases switch membrane location along the length of the larval midgut, indicating three possible regionalizations,whereas the adult stomach has uniform expression of basolateral P-type Na+/K+-ATPase and apical V-type H+-ATPase in each cell. In both larval and adult Malpighian tubules, the distal principal cells exhibit high expression levels of V-type H+-ATPase (apically and cytoplasmically) whereas P-type Na+/K+-ATPase is highly expressed in stellate cells found only in the distal two-thirds of each tubule. By contrast, the proximal principal cells express both P-type Na+/K+-ATPase (basal) and V-type H+-ATPase(apical). These results suggest a functional segregation along the length of the Malpighian tubules based on cell type and region. P-type Na+/K+-ATPase is the only pump apparent in the larval rectum whereas in the larval anal papillae and the adult hindgut (including the anterior hindgut and rectum with rectal pads), P-type Na+/K+-ATPase and V-type H+-ATPase localize to the basal and apical membranes, respectively. We discuss our findings in light of previous physiological and morphological studies and re-examine our current models of ion transport in these two developmental stages of mosquitoes that cope with disparate osmoregulatory challenges.
Correlation of C-start behaviors with neural activity recorded from the hindbrain in free-swimming goldfish (Carassius auratus)
Authors: Weiss Shennan A. , Zottoli Steven J. , Do Samantha C. , Faber Donald S. , Preuss Thomas 
Published: November 2006

SUMMARYStartle behaviors in teleost fishes are well suited for investigations of mechanisms of sensorimotor integration because the behavior is quantifiable and much of the underlying circuitry has been identified. The teleost C-start is triggered by an action potential in one of the two Mauthner (M) cells. To correlate C-start behavior with electrophysiology, extracellular recordings were obtained from the surface of the medulla oblongata in the hindbrain,close to the M-axons, in freely swimming goldfish monitored using high-speed video. The recordings included action potentials generated by the two M-axons,as well as neighboring axons in the dorsal medial longitudinal fasciculus. Axonal backfills indicated that the latter originate from identifiable reticulospinal somata in rhombomeres 2-8 and local interneurons. Diverse auditory and visual stimuli evoked behaviors with kinematics characteristic of the C-start, and the amplitude of the first component of the hindbrain field potential correlated with the C-start direction. The onset of the field potential preceded that of the simultaneously recorded trunk EMG and movement initiation by 1.08±0.04 and 8.13±0.17 ms, respectively. A subsequent longer latency field potential was predictive of a counterturn. These results indicate that characteristic features of the C-start can be extracted from the neural activity of the M-cell and a population of other reticulospinal neurons in free-swimming goldfish.