bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sublobar resection or lobectomy and postoperative respiratory complications in emphysematous lungs
Authors: Miura Kentaro , Ide Shogo , Minamisawa Masatoshi , Mishima Shuji , Matsuoka Shunichiro , Eguchi Takashi , Hamanaka Kazutoshi , Shimizu Kimihiro 
Published: March 2024

Abstract

OBJECTIVES
Pulmonary resection in patients with severe emphysema may impact postoperative respiratory complications. Low-attenuation areas evaluated using three-dimensional computed tomography to assess emphysematous changes are strongly associated with postoperative respiratory complications. Herein, we investigated the relationship between low-attenuation area, the surgical procedure and resected lung volume, which has not been explored in previous studies.

METHODS
We retrospectively evaluated patients with primary or metastatic lung cancer who underwent surgical resection. The low-attenuation area percentage (low-attenuation area/total lung area × 100) and resected lung volume were calculated using three-dimensional computed tomography software, and the relationship with postoperative respiratory complications was analysed.

RESULTS
Postoperative respiratory complications occurred in 66 patients (17%) in the total cohort (n = 383). We set the median value of 1.1% as the cut-off value for low-attenuation area percentage to predict postoperative respiratory complications, which occurred in 24% and 10% of patients with low-attenuation area &gt;1.1% and &lt;1.1%, respectively (P &lt; 0.001). Postoperative respiratory complications occurred in approximately one-third of the patients with low-attenuation area &gt;1.1%, whose resected lung volume was ≥15.8% or ≥5 resected subsegments. Multivariable analysis revealed that sublobar resection was associated with a significantly lower risk of postoperative respiratory complications in patients with low-attenuation area &gt;1.1% (odds ratio 0.4, 95% confidence interval 0.183–0.875).

CONCLUSIONS
Emphysema is a risk factor for postoperative respiratory complications, and lobectomy is an independent predictive risk factor. Preserving more lung parenchyma may yield better short-term prognoses in patients with emphysematous lungs.
Clinical benefits of surgical ablation during isolated aortic valve replacement: a nationwide study
Authors: Kim Ji Seong , Kim Jinhee , Kang Yoonjin , Sohn Suk Ho , Lee Yewon , Kim Sue Hyun , Hwang Ho Young , Kim Kyung Hwan , Kim Mi-Sook , Choi Jae Woong 
Published: March 2024

Abstract

OBJECTIVES
To compare the early- and long-term clinical outcomes of concomitant surgical ablation (SA) for atrial fibrillation (AF) during isolated aortic valve replacement (AVR) using data from the Korean National Health Insurance Service Database.

METHODS
Of 23,332 adult patients who underwent AVR between 2003 and 2019, those with underlying AF with or without concomitant SA were extracted, and propensity score matching analysis was performed.

RESULTS
Overall, 1,741 patients with underlying AF with (n = 445, group A) or without (n = 1,296, group N) concomitant SA during isolated AVR were enrolled, from whom 435 pairs were matched in a 1:1 ratio using propensity score matching analysis. The operative mortality and early postoperative morbidities, including bleeding reoperation, stroke, permanent pacemaker implantation and acute kidney injury were comparable between the groups. The overall survival showed no differences between the groups. However, the cumulative incidence of new-onset late ischaemic stroke was significantly lower in group A than group N in propensity score-matched patients [2.3 vs 3.5 per 100 patient-years, adjusted hazard ratio (95% confidence interval) 0.64 (0.43–0.96), Group A versus Group N, respectively]. The cumulative incidence of other morbidities such as reoperation, permanent pacemaker implantation and progression to chronic renal failure showed no difference between groups.

CONCLUSIONS
The incidence of late ischaemic stroke was significantly lower when concomitant SA was performed during isolated AVR in patients with underlying AF. Therefore, concomitant SA should be actively considered in patients with underlying AF undergoing isolated AVR to prevent the occurrence of late ischaemic stroke.
Digital multimodal composing pedagogy in a university writing course
Authors: Ho Wing Yee Jenifer 
Published: March 2024

Abstract
Digital multimodal composing (DMC) allows students to mobilize a wide range of multimodal resources to make meaning. While studies in DMC tended to focus on language-learning contexts, few of them examine its use in content-based courses whereby students are proficient L2 users expected to demonstrate understanding of abstract concepts using DMC. Drawing on semi-structured interviews with English-major students who attended a writing course in an English-medium instruction university in Hong Kong, the study investigated how the students’ view of DMC was transformed after exposure to DMC pedagogy. The study findings suggest that students developed an increased awareness of the affordances and constraints of (new media) writing, and they strategically bring in and bridge ‘in-class’ and ‘out-of-class’ digital practices. Students also reported on the opportunities and challenges of DMC pedagogy through reflecting on their DMC experiences. The study proposes suggestions for implementing DMC in diverse teaching and learning contexts.
Pseudomonas aeruginosa from river water: antimicrobial resistance, virulence and molecular typing
Authors: Rojo-Bezares Beatriz , Casado Cristina , Ceniceros Tania , López María , Chichón Gabriela , Lozano Carmen , Ruiz-Roldán Lidia , Sáenz Yolanda 
Published: March 2024

Abstract
Pseudomonas aeruginosa isolates were recovered from surface river water samples in La Rioja region (Spain) to characterise their antibiotic resistance, molecular typing and virulence mechanisms. Fifty-two P. aeruginosa isolates were isolated from 15 different water samples (45.4%) and belonged to 23 different pulsed-field electrophoresis (PFGE) patterns. All isolates were susceptible to all antibiotics tested, except one carbapenem-resistant P. aeruginosa that showed a premature stop codon in OprD porin. Twenty-two sequence types (STs) (six new ones) were detected among 29 selected P. aeruginosa (one strain with a different PFGE pattern per sample), with ST274 (14%) being the most frequent one. O:6 and O:3 were the predominant serotypes (31%). Seven virulotypes were detected, being 59% exoS-exoY-exoT-exoA-lasA-lasB-lasI-lasR-rhlAB-rhlI-rhlR-aprA-positive P. aeruginosa. It is noteworthy that the exlA gene was identified in three strains (10.3%), and the exoU gene in seven (24.1%), exoS in 18 (62.1%), and both exoS and exoU genes in one strain. High motility ranges were found in these strains. Twenty-seven per cent of strains produced more biofilm biomass, 90% more pyorubin, 83% more pyocyanin and 65.5% more than twice the elastase activity compared with the PAO1 strain. These results highlight the importance of rivers as temporary reservoirs and sources of P. aeruginosa transmission, and show the importance of their epidemiological surveillance in the environment.
Circular RNA CircVmn2r1 Acts as a miR-223-3p Sponge to Promote Kidney Aging by Regulating NLRP3 Expression in Mice
Authors: Gao Fanfan , Wei Limin , Li Jie , Zeng Lu , Wang Meng , Lan Ping , Liang Shanshan , Huang Xinmei , Chen Lei , Jiang Hongli  
Published: March 2024

Abstract
Kidney aging accelerates the progression of various acute and chronic kidney diseases and can also induce pathological changes in other organs throughout the body. Circular RNAs (circRNAs) have been demonstrated to play a vital role in aging and age-related diseases. However, biological functions and the underlying molecular mechanism of circRNAs in kidney aging remain largely unclear. Uncovering the functions of circRNAs in kidney aging and their underlying regulatory mechanisms may shed new light on the development of novel diagnostic and therapeutic strategies for human aging. Here, we report the important role of circVmn2r1 in the progression of kidney aging. We found that circVmn2r1 was one of the top expressed circRNAs in mouse kidney by RNA sequencing and was significantly upregulated in 24-month-old mouse kidney compared to 3-month-old. More importantly, we demonstrated that overexpression of circVmn2r1 promoted kidney aging in senescence-accelerated mouse prone 8 mice. Cellular assays with mouse kidney tubular epithelium (TCMK-1) cells under both gain-of-function and loss-of-function conditions demonstrated that circVmn2r1 inhibited proliferation and promoted senescence, whereas miR-223-3p counteracted these effects. Mechanistic analysis demonstrated that circVmn2r1 acted as a miR-223-3p sponge to relieve the repressive effect of miR-223-3p on its target NLRP3, which we proved could inhibit proliferation and promote senescence of TCMK-1 cells. Our results indicate that circVmn2r1 promotes kidney aging through acting as a miR-223-3p sponge, consequently upregulating NLRP3 expression, and can be a valuable diagnostic marker and an important therapeutic target for kidney aging.
Integrative Multimodal Metabolomics to Early Predict Cognitive Decline Among Amyloid Positive Community-Dwelling Older Adults
Authors: Tremblay-Franco Marie , Canlet Cécile , Carriere Audrey , Nakhle Jean , Galinier Anne , Portais Jean-Charles , Yart Armelle , Dray Cédric , Lu Wan-Hsuan , Bertrand Michel Justine , Guyonnet Sophie , Rolland Yves , Vellas Bruno , Delrieu Julien , Barreto Philippe de Souto , Pénicaud Luc , Casteilla Louis , Ader Isabelle ,   MAPT/DSA Group
Published: March 2024

Abstract
Alzheimer’s disease is strongly linked to metabolic abnormalities. We aimed to distinguish amyloid-positive people who progressed to cognitive decline from those who remained cognitively intact. We performed untargeted metabolomics of blood samples from amyloid-positive individuals, before any sign of cognitive decline, to distinguish individuals who progressed to cognitive decline from those who remained cognitively intact. A plasma-derived metabolite signature was developed from Supercritical Fluid chromatography coupled with high-resolution mass spectrometry (SFC-HRMS) and nuclear magnetic resonance (NMR) metabolomics. The 2 metabolomics data sets were analyzed by Data Integration Analysis for Biomarker discovery using Latent approaches for Omics studies (DIABLO), to identify a minimum set of metabolites that could describe cognitive decline status. NMR or SFC-HRMS data alone cannot predict cognitive decline. However, among the 320 metabolites identified, a statistical method that integrated the 2 data sets enabled the identification of a minimal signature of 9 metabolites (3-hydroxybutyrate, citrate, succinate, acetone, methionine, glucose, serine, sphingomyelin d18:1/C26:0 and triglyceride C48:3) with a statistically significant ability to predict cognitive decline more than 3 years before decline. This metabolic fingerprint obtained during this exploratory study may help to predict amyloid-positive individuals who will develop cognitive decline. Due to the high prevalence of brain amyloid-positivity in older adults, identifying adults who will have cognitive decline will enable the development of personalized and early interventions.
Study on optimal allocation of energy storage in multi-regional integrated energy system considering stepped carbon trading
Authors: Zheng Weimin , Zou Bo , Gu Jiting , Chen Jiaqian , Hou Jiansheng 
Published: March 2024

Abstract
In this study, an energy storage configuration optimization model of multi regional integrated energy system based on integrated scheduling and stepped Carbon emission trading is proposed. By analyzing the steady-state, dynamic, and variable operating characteristics of multi regional integrated energy systems, a distributed energy planning modeling method was adopted to construct energy storage configuration constraint objects and optimization models. The target scheme of energy storage configuration is optimized by using the results of integrated scheduling scheme and dynamic distribution analysis of ladder Carbon emission trading, and the parameters are optimally estimated by using Monte Carlo method and quadratic fitting algorithm. The simulation results show that this method has a strong scheduling capability in the context of stepped Carbon emission trading, can accurately assess the load demand and supply demand relationship, reduce carbon emissions, and improve energy efficiency, with an average of 0.9121.
Examining the sustainable impact of urban expansion and urban expansion policies on archaeological sites: evidence from Jordan and Saudi Arabia
Authors: Alsubeh Mahmoud Ali , Helmi Mansour Rifaat 
Published: March 2024

Abstract
This research aims to explore the effect of urban expansion on archaeological sites, particularly those located within the urban fabric. The researcher will present maps of Jeddah in Saudi Arabia and Amman in the Hashemite Kingdom of Jordan from 2004 to 2018, highlighting the changes in urban expansion policies and their impact on these archaeological sites. Moreover, this study takes into account the concept of sustainability in urban expansion. Some studies have reported that populations will be more concentrated in urban areas and that cities will continue to grow (Min et al., 2019). As a result of this rapid urban growth, there is a pressing need to consider the sustainability of these developments, including their impact on archaeological sites. By examining the positive and negative changes in archaeological sites surrounded by the urban fabric, this research seeks to identify the main reasons behind these changes. Furthermore, this study will propose suggestions for improving policies and procedures in these cities regarding the preservation of archaeological sites, with a focus on sustainability.
Infinitesimal Deformations of Some Quot Schemes
Authors: Biswas Indranil , Gangopadhyay Chandranandan , Sebastian Ronnie 
Published: March 2024

Abstract
Let $E$ be a vector bundle on a smooth complex projective curve $C$ of genus at least two. Let $\mathcal{Q}(E,d)$ be the Quot scheme parameterizing the torsion quotients of $E$ of degree $d$. We compute the cohomologies of the tangent bundle $T_{\mathcal{Q}(E,d)}$. In particular, the space of infinitesimal deformations of $\mathcal{Q}(E,d)$ is computed. Kempf and Fantechi computed the space of infinitesimal deformations of $\mathcal{Q}({\mathcal O}_{C},d)\,=\, C^{(d)}$ [ 11, 19].
Round-up of European enforcement case law 2023
Authors: Gommers Carina , Leppink Willem , Schneider Marius 
Published: March 2024

Abstract
In 2023, several noteworthy decisions relating to the enforcement of intellectual property rights (IPRs) were handed down, including in relation to anti-counterfeiting, parallel trade, litigation aspects and restrictions on the enforcement of IPRs. The decisions of the Court of Justice of the European Union and Supreme Courts and Courts of Appeals of the European Union Member States that the authors consider important are summarized in this contribution. The judgments were rendered between 1 January 2023 and 31 December 2023. As in previous editions, the authors have adopted a practical approach aimed at readers seeking an overview of the key IPR enforcement decisions of 2023.
Exploring the interaction between physical, psychosocial, and neck pain symptoms in construction workers
Authors: Kusmasari Wyke , Sutarto Auditya Purwandini , Dewi Nugrahaning Sani , Yassierli   , Yudhistira Titah , Muslim Khoirul , Sanjaya Kadek Heri , Haqiyah Aridhotul , Lestari Wahyu Dwi 
Published: March 2024

Abstract

Objectives:
Construction workers are particularly vulnerable to musculoskeletal disorders, yet the number of studies conducted in developing nations—where these workers contribute significantly to the economy—remains insufficient. This study aims to explore the interaction between physical and psychosocial exposure and the onset of neck pain or symptoms among construction workers in a developing country.

Methods:
Using a cross-sectional study design, a total of 235 respondents from various construction projects participated in this study. Participants were assigned to one of 4 exposure groups: low physical and low psychosocial (which served as the reference group); low physical and high psychosocial; high physical and low psychosocial; and high physical and high psychosocial. To quantitatively assess the interaction, we calculated the relative excess risk due to interaction (RERI), attributable proportion (AP), and synergy index (SI).

Results:
Workers experiencing high levels of both physical and psychosocial risk factors had the highest odds ratio (OR) of neck symptoms (OR: 12.63; 95% CI: 3.39-46.99) compared with other groups. The AP (0.33; 95% CI: −0.24 to 0.90), RERI (0.40; 95% CI: −0.99 to 1.79), and SI (1.69; 95% CI: −1.77 to 5.15) revealed an interaction between physical and psychosocial factors that increases the OR of neck symptoms.

Conclusions:
This result suggests that physical risk factors at work become significantly more detrimental when paired with high psychosocial stress. Hence, ergonomic interventions in the construction industry aiming to reduce musculoskeletal disorders should consider both physical and psychosocial risk factors concurrently.
Diffraction-Based Multiscale Residual Strain Measurements
Authors: Pai Namit , Manda Sanjay , Sudhalkar Bhargav , Syphus Bethany , Fullwood David , de Kloe René , Wright Stuart , Patra Anirban , Samajdar Indradev 
Published: March 2024

Abstract
Modern analytical tools, from microfocus X-ray diffraction (XRD) to electron microscopy-based microtexture measurements, offer exciting possibilities of diffraction-based multiscale residual strain measurements. The different techniques differ in scale and resolution, but may also yield significantly different strain values. This study, for example, clearly established that high-resolution electron backscattered diffraction (HR-EBSD) and high-resolution transmission Kikuchi diffraction (HR-TKD) [sensitive to changes in interplanar angle (Δθθ)], provide quantitatively higher residual strains than micro-Laue XRD and transmission electron microscope (TEM) based precession electron diffraction (PED) [sensitive to changes in interplanar spacing (Δdd)]. Even after correcting key known factors affecting the accuracy of HR-EBSD strain measurements, a scaling factor of ∼1.57 (between HR-EBSD and micro-Laue) emerged. We have then conducted “virtual” experiments by systematically deforming an ideal lattice by either changing an interplanar angle (α) or a lattice parameter (a). The patterns were kinematically and dynamically simulated, and corresponding strains were measured by HR-EBSD. These strains showed consistently higher values for lattice(s) distorted by α, than those altered by a. The differences in strain measurements were further emphasized by mapping identical location with HR-TKD and TEM-PED. These measurements exhibited different spatial resolution, but when scaled (with ∼1.57) provided similar lattice distortions numerically.
Liquid Cell Transmission Electron Microscopy for Real-World Problems
Authors: Ross Frances M 
Published: March 2024

Abstract
Transmission electron microscopy of liquid samples is a relatively new technique that has the potential to reveal processes taking place within electrochemical, catalytic, and biological systems, during crystal growth from solution, and at the liquid/air interface. It is technically demanding yet can provide unique views of processes and structures in liquid environments. We will describe some highlights of the development of this technique and the equipment required to use it, explore questions that it can help address in microelectronics and battery research, and speculate on future directions and opportunities.
Exploring the nature of UV-bright z ≳ 10 galaxies detected by JWST: star formation, black hole accretion, or a non-universal IMF?
Authors: Trinca Alessandro , Schneider Raffaella , Valiante Rosa , Graziani Luca , Ferrotti Arianna , Omukai Kazuyuki , Chon Sunmyon 
Published: March 2024

ABSTRACT
We use the Cosmic Archaeology Tool (CAT) semi-analytical model to explore the contribution of Population (Pop) III/II stars and active galactic nuclei (AGNs) to the galaxy ultraviolet (UV) luminosity function (LF) evolution at 4 ≤ z ≤ 20. We compare in particular with recent JWST data in order to explore the apparent tension between observations and theoretical models in the number density of bright galaxies at z ≳ 10. The model predicts a star formation history dominated by UV faint (MUV &gt; −18) galaxies, with a Pop III contribution of $\lesssim 10~{{\ \rm per\ cent}}$ ($\lesssim 0.5~{{\ \rm per\ cent}}$) at z ≃ 20 (z ≃ 10). Stars are the primary sources of cosmic reionization, with $5~{{\ \rm per\ cent}}\!-\!10~{{\ \rm per\ cent}}$ of ionizing photons escaping into the intergalatic medium at 5 ≤ z ≤ 10, while the contribution of unobscured AGNs becomes dominant only at z ≲ 5. The predicted stellar and AGN UV LFs reproduce the observational data at 5 ≲ z ≲ 9–10. At higher redshift, CAT predicts a steeper evolution in the faint-end slope (MUV &gt; –18), and a number density of bright galaxies (MUV ≃ −20) consistent with data at z ∼ 10–11, but smaller by 0.8 dex at z ∼ 12–13, and 1.2 dex at z ∼ 14–16, when compared to the values estimated by recent studies. Including the AGN emission does not affect the above findings, as AGNs contribute at most to $\lesssim 10~{{\ \rm per\ cent}}$ of the total UV luminosity at MUV &lt; –19 and z ≳ 10. Interestingly, considering a gradual transition in the stellar initial mass function, modulated by metallicity and redshift as suggested by recent simulations, the model agrees with JWST data at z ∼ 12–13, and the disagreement at z ∼ 14–16 is reduced to 0.5 dex.
3D volume growth rate evaluation in the EORTC-BTG-1320 clinical trial for recurrent WHO grade 2 and 3 meningiomas
Authors: Tabouret Emeline , Furtner Julia , Graillon Thomas , Silvani Antonio , Le Rhun Emilie , Soffietti Riccardo , Lombardi Giuseppe , Sepúlveda-Sánchez Juan Manuel , Brandal Petter , Bendszus Martin , Golfinopoulos Vassilis , Gorlia Thierry , Weller Michael , Sahm Felix , Wick Wolfgang , Preusser Matthias 
Published: March 2024

Abstract

Background
We previously reported that tumor 3D volume growth rate (3DVGR) classification could help in the assessment of drug activity in patients with meningioma using 3 main classes and a total of 5 subclasses: class 1: decrease; 2: stabilization or severe slowdown; 3: progression. The EORTC-BTG-1320 clinical trial was a randomized phase II trial evaluating the efficacy of trabectedin for recurrent WHO 2 or 3 meningioma. Our objective was to evaluate the discriminative value of 3DVGR classification in the EORTC-BTG-1320.

Methods
All patients with at least 1 available MRI before trial inclusion were included. 3D volume was evaluated on consecutive MRI until progression. 2D imaging response was centrally assessed by MRI modified Macdonald criteria. Clinical benefit was defined as neurological or functional status improvement or steroid decrease or discontinuation.

Results
Sixteen patients with a median age of 58.5 years were included. Best 3DVGR classes were: 1, 2A, 3A, and 3B in 2 (16.7%), 4 (33.3%), 2 (16.7%), and 4 (33.3%) patients, respectively. All patients with progression-free survival longer than 6 months had best 3DVGR class 1 or 2. 3DVGR classes 1 and 2 (combined) had a median overall survival of 34.7 months versus 7.2 months for class 3 (P = .061). All class 1 patients (2/2), 75% of class 2 patients (3/4), and only 10% of class 3 patients (1/10) had clinical benefit.

Conclusions
Tumor 3DVGR classification may be helpful to identify early signals of treatment activity in meningioma clinical trials.