bluuebunny/crossref_metadata_2025_split huggingface dataset:
RUNX1 promotes angiogenesis in colorectal cancer by regulating the crosstalk between tumor cells and tumor associated macrophages
Authors: Guo Xuxue , Zhang Haonan , He Chengcheng , Qin Kaiwen , Lai Qiuhua , Fang Yuxin , Chen Qianhui , Li Weize , Wang Yiqing , Wang Xinke , Li Aimin , Liu Side , Li Qingyuan 
Published: February 2024

AbstractColorectal cancer (CRC) is a common malignancy worldwide. Angiogenesis and metastasis are the critical hallmarks of malignant tumor. Runt-related transcription factor 1 (RUNX1), an efficient transcription factor, facilitates CRC proliferation, metastasis and chemotherapy resistance. We aimed to investigate the RUNX1 mediated crosstalk between tumor cells and M2 polarized tumor associated macrophages (TAMs) in CRC, as well as its relationship with neoplastic angiogenesis. We found that RUNX1 recruited macrophages and induced M2 polarized TAMs in CRC by promoting the production of chemokine 2 (CCL2) and the activation of Hedgehog pathway. In addition, we found that the M2 macrophage-specific generated cytokine, platelet-derived growth factor (PDGF)-BB, promoted vessel formation both in vitro and vivo. PDGF-BB was also found to enhance the expression of RUNX1 in CRC cell lines, and promote its migration and invasion in vitro. A positive feedback loop of RUNX1 and PDGF-BB was thus formed. In conclusion, our data suggest that RUNX1 promotes CRC angiogenesis by regulating M2 macrophages during the complex crosstalk between tumor cells and TAMs. This observation provides a potential combined therapy strategy targeting RUNX1 and TAMs-related PDGF-BB in CRC.
Investigating the effect of COVID-19 disruption in education using REDS data
Authors: Bertoletti Alice , Karpiński Zbigniew 
Published: February 2024

AbstractThe Covid-19 pandemic has triggered a rapid and unprecedented transformation of global educational systems. The research community has uncovered important impacts of the pandemic on education worldwide, including detrimental effects on student learning, a decline in the well-being of teachers and students, and the exacerbation of educational disparities. Within this context, the Response to Education Disruption Survey (REDS) database stands out as one of the first large-scale international surveys specifically designed to examine the disruption caused by Covid-19 in education. This database serves as an initial step towards providing a more comprehensive understanding of the worldwide effects of the pandemic on education. The relevance of this database has inspired the creation of this special issue, collecting six studies that analyse the consequences of Covid-19 using REDS data.
A comparative analysis of TonEBP conditional knockout mouse models reveals inter-dependency between compartments of the intervertebral disc
Authors: Couasnay Greig , Garcia Haley , Elefteriou Florent 
Published: February 2024

ABSTRACT
Interactions between notochord and sclerotome are required for normal embryonic spine patterning, but whether the postnatal derivatives of these tissues also require interactions for postnatal intervertebral disc (IVD) growth and maintenance is less established. We report here the comparative analysis of four conditional knockout mice deficient for TonEBP, a transcription factor known to allow cells to adapt to changes in extracellular osmotic pressure, in specific compartments of the IVD. We show that TonEBP deletion in nucleus pulposus (NP) cells does not affect their survival or aggrecan expression, but promoted cell proliferation in the NP and in adjacent vertebral growth plates (GPs). In cartilage end plates/GPs, TonEBP deletion induced cell death, but also structural alterations in the adjacent NP cells and vertebral bodies. Embryonic or postnatal TonEBP loss generated similar IVD changes. In addition to demonstrating the requirement of TonEBP in the different compartments of the IVD, this comparative analysis uncovers the in vivo interdependency of the different IVD compartments during the growth of the postnatal IVD-vertebral units.
Disentangling physiological and physical explanations for body size-dependent thermal tolerance
Authors: Gunderson Alex R. 
Published: February 2024

ABSTRACT
The effects of climate change are often body size dependent. One contributing factor could be size-dependent thermal tolerance (SDTT), the propensity for heat and cold tolerance to vary with body size among species and among individuals within species. SDTT is hypothesized to be caused by size differences in the temperature dependence of underlying physiological processes that operate at the cellular and organ/system level (physiological SDTT). However, temperature-dependent physiology need not change with body size for SDTT to be observed. SDTT can also arise because of physical differences that affect the relative body temperature dynamics of large and small organisms (physical SDTT). In this Commentary, I outline how physical SDTT occurs, its mechanistic differences from physiological SDTT, and how physical and physiological SDTT make different predictions about organismal responses to thermal variation. I then describe how physical SDTT can influence the outcome of thermal tolerance experiments, present an experimental framework for disentangling physical and physiological SDTT, and provide examples of tests for physiological SDTT that control for physical effects using data from Anolis lizards. Finally, I discuss how physical SDTT can affect organisms in natural environments and influence their vulnerability to anthropogenic warming. Differentiating between physiological and physical SDTT is important because it has implications for how we design and interpret thermal tolerance experiments and our fundamental understanding of thermal ecology and thermal adaptation.
Exact Solution of the Single-Picker Routing Problem with Scattered Storage
Authors: Heßler Katrin , Irnich Stefan 
Published: February 2024

We present a new modeling approach for the single-picker routing problem with scattered storage (SPRP-SS) for order picking in warehouses. The SPRP-SS assumes that an article is, in general, stored at more than one pick position. The task is then the simultaneous selection of pick positions for requested articles and the determination of a minimum-length picker tour collecting the articles. It is a classical result of Ratliff and Rosenthal that, for given pick positions, an optimal picker tour is a shortest path in the state space of a dynamic program with a linear number of states and transitions. We extend the state space of Ratliff and Rosenthal to include scattered storage so that every feasible picker tour is still a path. The additional requirement to make consistent decisions regarding articles to collect is not modeled in the state space so that dynamic programming can no longer be used for the solution. Instead, demand covering can be modeled as additional constraints in shortest-path problems. Therefore, we solve the resulting model with a mixed-integer (linear) programming (MIP) solver. The paper shows that this approach is not only convenient and elegant for single-block parallel-aisle warehouse SPRP-SSs but also generalizable: the solution principle can be applied to different warehouse layouts (we present additional results for a two-block parallel-aisle warehouse) and can incorporate further extensions. Computational experiments with other approaches for the SPRP-SS show that the new modeling approach outperforms the available exact algorithms regarding computational speed. History: Accepted by Andrea Lodi, Area Editor for Design and Analysis of Algorithms—Discrete. Supplemental Material: The e-companion is available at https://doi.org/10.1287/ijoc.2023.0075 .
ERA UMA ESCOLA MUITO ENGRAÇADA
Authors: Silva Luiza Helena Oliveira da 
Published: February 2024

Orientado pelos estudos da semiótica discursiva destinados ao espaço, este trabalho analisa três dissertações do PROFLETRAS – Programa de Mestrado Profissional em Rede Nacional – defendidos por docentes que atuam nos estados do Pará e Acre, nos anos de 2017 e 2019. O objetivo foi o de analisar os sentidos que se produzem sobre o espaço da escola onde atuam e/ou desenvolveram práticas interventivas. Buscou-se observar a possível reiteração de imagens de escolas públicas caracterizadas pela privação, a serem depreendidas das narrativas e escolhas enunciativas projetadas nos textos. As dissertações analisadas explicitam performances realizadas no espaço utópico (GREIMAS, 1985), o da sala de aula, ou a construção de utopias a serem alcançadas pela formação teórico-prática ofertada pelo referido programa de mestrado. Inserido no âmbito de uma pesquisa em desenvolvimento, o recorte apresentado privilegiou imagens que seriam produzidas por escolas situadas na região Norte.
Clinical characteristics of testicular torsion and factors influencing testicular salvage in children: A 12-year study in tertiary center
Authors: Gang Xiang-Hui , Duan Yuan-Yuan , Zhang Bin , Jiang Zheng-Gan , Zhang Rong , Chen Jun , Teng Xiang-Yu , Zhang Duo-Bing 
Published: February 2024

BACKGROUND
Testicular torsion is the most common acute scrotum worldwide and mainly occurs in children and adolescents. Studies have demonstrated that the duration of symptoms and torsion grade lead to different outcomes in children diagnosed with testicular torsion.
AIM
To predict the possibility of testicular salvage (TS) in patients with testicular torsion in a tertiary center.
METHODS
We reviewed the charts of 75 pediatric patients with acute testicular torsion during a 12-year period from November 2011 to July 2023 at the Suzhou Hospital of Anhui Medical University. Univariate and multivariate logistic regression analyses were used to determine independent predictors of testicular torsion. The data included clinical findings, physical examinations, laboratory data, color Doppler ultrasound findings, operating results, age, presenting institution status, and follow-up results.
RESULTS
Our study included 75 patients. TS was possible in 57.3% of all patients; testicular torsion occurred mostly in winter, and teenagers aged 11-15 years old accounted for 60%. Univariate logistic regression analyses revealed that younger age (P = 0.09), body mass index (P = 0.004), torsion angle (P = 0.013), red blood cell count (P = 0.03), neutrophil-to-lymphocyte ratio (P = 0.009), and initial presenting institution (P < 0.001) were associated with orchiectomy. In multivariate analysis, only the initial presenting institution predicted TS (P < 0.05).
CONCLUSION
The initial presenting institution has a predictive value for predicting TS in patients with testicular torsion. Children with scrotal pain should be admitted to a tertiary hospital as soon as possible.
Current practice of hospital-based palliative care teams: Advance care planning in advanced stages of disease: A retrospective observational study
Authors: van Doorne Iris , Willems Dick L. , Baks Nadine , de Kuijper Jelle , Buurman Bianca M. , van Rijn Marjon 
Published: February 2024

Background
Specialist palliative care teams are consulted during hospital admission for advice on complex palliative care. These consultations need to be timely to prevent symptom burden and maintain quality of life. Insight into specialist palliative care teams may help improve the outcomes of palliative care.

Methods
In this retrospective observational study, we analyzed qualitative and quantitative data of palliative care consultations in a six-month period (2017 or 2018) in four general hospitals in the northwestern part of the Netherlands. Data were obtained from electronic medical records.

Results
We extracted data from 336 consultations. The most common diagnoses were cancer (54.8%) and organ failure (26.8%). The estimated life expectancy was less than three months for 52.3% of all patients. Within two weeks after consultation, 53.2% of the patients died, and the median time until death was 11 days (range 191) after consultation. Most patients died in hospital (49.4%) but only 7.5% preferred to die in hospital. Consultations were mostly requested for advance care planning (31.6%). End-of-life preferences focused on last wishes and maintaining quality of life.

Conclusion
This study provides detailed insight into consultations of palliative care teams and shows that even though most palliative care consultations were requested for advance care planning, consultations focus on end-of-life care and are more crisis-oriented than prevention-oriented. Death often occurs too quickly after consultation for end-of-life preferences to be met and these preferences tend to focus on dying. Educating healthcare professionals on when to initiate advance care planning would promote a more prevention-oriented approach. Defining factors that indicate the need for timely palliative care team consultation and advance care planning could help timely identification and consultation.
A Cross-Sectional Study Examining the Behavioral Patterns and Attitudes of First - and Second-Year Medical College Students in West Bengal, India, Regarding Self-Medication
Authors: Rupayan Kundu  , Nivedita Sarkar  , Tuhin Subhra Pal  
Published: February 2024

BACKGROUND
Self-medication is a pervasive habit, and drug abuse is a severe problem. Since medical students are future doctors, they give it a unique significance. The study's objectives were to assess the practice, knowledge, and attitudes of first- and second-year medical students at a medical college in West Bengal, India, about self-medication.
METHODS
The study was conducted in Nilratan Sircar Medical College and Hospital, Kolkata, West Bengal. In 2021, medical students across the colleges of West Bengal conducted cross-sectional research using questionnaires. Upon being informed of the objectives and design of the study, first- and second-year MBBS students willingly agreed to participate.
RESULTS
In this study, 91.50% of medical students practiced self-medication. The common indication for self-medication was fever (89.2%) and headache (69.6%). Previous prescriptions for the same illness (68.87%) were the main source of information for self-medication. Common reasons for self-medication were urgency (53.33%) and quick relief (50%). Over-the-counter (88.14%) drugs were the most common sources of medications. The common preferred system of self-medication was allopathic (92.5%). The percentage of discontinuation (58.1%) of self-medication was more. The majority of them favoured oral (96.67%) media.
CONCLUSIONS
It was determined that more than half of the student population self-medicated for a wide range of ailments; the cause may be the increased public awareness of drugs brought on by the availability of information via books, the internet, and over-the-counter medications from pharmacists. Therefore, it is crucial to stop students from self-medicating to prevent the emergence of drug habits, resistance, and drug interactions.
Ein toolgestützter Ansatz für die benutzerfreundliche Definition von Funktionsbaustein-Einschränkungen
Authors: Wiesmayr Bianca , Roithmayr Felix , Zoitl Alois 
Published: February 2024

Zusammenfassung
An Steuerungsprogramme werden hohe Anforderungen hinsichtlich Korrektheit und Robustheit gestellt. Moderne Werkzeuge können Entwickler*innen bei der Erstellung von Programmen unterstützen. Der Schwerpunkt dieses Artikels liegt auf der expliziten Modellierung von implizitem Wissen der Entwickler*innen, da diese Informationen für die automatische Überprüfung von Programmen nötig sind. In diesem Artikel stellen wir ein Konzept zur Definition von Einschränkungen an der Schnittstelle von Funktionsbausteinen dar. Diese sollen Annahmen über das Verhalten anderer Komponenten oder der physischen Umgebung festhalten. Diese Einschränkungen werden für die Erzeugung von Überwachungsbausteinen genutzt.
A review of emerging trends in Laves phase research: Bibliometric analysis and visualization
Authors: Xiao Xuan , Jin Maomao , Qin Wenzhou , Yao Jing 
Published: February 2024

Abstract
The rapid development of modern aerospace and energy industries requires increasingly high service performance of metallic materials. Laves phase intermetallic compounds with the chemical formula AB2-type have attracted much attention due to their high melting point, excellent high-temperature strength, and oxidation resistance, and are regarded as one of the promising candidates for a new generation of high-temperature structural applications. Although it can be identified that Laves phase alloy research has been an active research field in the last 20 years in terms of the trend of literature volume growth, there is still a lack of systematic descriptions and comprehensive overviews of the latest frontiers and hotspots in the field. In this article, a quantitative and visual knowledge mapping of the articles published in the field of Laves phase research in the last 20 years has been carried out based on the bibliometric analysis methodology of Cite Space software. Quantitative analysis of high-frequency keywords to understand the basic development of Laves phase and the evolution of the main research hotspots in each period of time identified the hotspots of common concern seven themes: Laves phase, electronic structure, precipitation, Inconel 718 alloy, phase diagram, high-entropy alloys, and TiAl-based alloys. The analysis of the emergent keywords shows that electronic structure, high-entropy alloys, total energy calculations, and laser cladding can represent the research frontiers of Laves phases. This study provides systematic and valuable reference information to gain insight into the current state of Laves phase research and the evolution of the theme, which will be useful for further research.
A study on porosity investigation of compacted bentonite in various densities by using micro-computed tomography images analysis
Authors: Yang Wudi , Chen Jui-Chi , Li Jing-Xing , Yang Song , Shi Yunfeng , Chen Chien-Jung , Lu Hui-Min , Lu Chien-Ping , Tsai Fang-Chang , Lee Chuan-Pin 
Published: February 2024

Abstract
Compacting a material means applying pressure so that the material itself loses its internal pores. It improves the homogeneity of the material itself and increases its density. The pore structure of compacted clay is also an important factor that affects its mechanical properties, permeability and water absorption. In this study, MX-80 bentonite clay was first compacted into round cakes of different densities and then subjected to tomography image analysis technique using micro-computed tomography (micro-CT) at millimeter scale of accuracy for 1.0–2.0 g/cm3 compacted clay (thickness of 0.3 cm bentonite compacted clay). In this paper, we use the latest commercial specifically for scientific visualization, materials science, non-destructive testing, numerical simulation of chromatographic imaging and other functions of a powerful visualization of the image analyzing method.
Undergraduate and Postgraduate Students’ Needs and Expectations of Digital Scholarship Spaces in a Comprehensive University Library: A Survey
Authors: Zhu Qiandong , Xie Xiaozhen 
Published: February 2024

Abstract
The development of digital and mobile technology has led to the emergence of digital scholarship, which is a challenge but also an opportunity for higher education institutions to improve their space and relevant services to support students’ success. The purpose of this study is to explore university students’ needs and expectations on digital scholarship spaces and relevant services in an academic library, as well as the differences in this based on gender, academic identity, and subject being studied. We conducted a survey at Shipai campus of Jinan University in Guangzhou to collect and analyze users’ needs and expectations. Among the digital scholarship service, the demand scores of the top three services are text recognition and full-text processing with 7.00, academic paper writing, submission, publication, and dissemination consulting services with 6.86, and digitization of printed documents with 6.72. Elsewhere, the demand score of the top three spaces are the online digital scholarship space with 6.57, the research project application and exchange space with 6.43, and the text analysis, data analysis, Big Data, and visualization service center with 6.27. With the improvement of academic identity, the demand for digital scholarship services is higher. Gender has led to differences in a small number of space needs, while the differences brought about by the subject being studied are more significant. This research contributes to the understanding of how the digital technology, the students’ spaces needs, and relevant management practice merge in academic libraries for students’ learning and research purposes. These have implications for universities to improve their libraries’ space services oriented to the diverse users’ digital scholarship needs in the current digital learning environment.
Harmonic quantum cascade laser terahertz frequency combs enabled by multilayer graphene top-cavity scatters
Authors: Justo Guerrero Manuel Alejandro , Arif Omer , Sorba Lucia , Vitiello Miriam Serena 
Published: February 2024

Abstract
Optical frequency comb synthesizers, operating in the harmonic regime, are metrological sources in which the emitted optical power is concentrated in a few modes, spaced by several multiples of the cavity free spectral range (FSR). This behavior reflects in a large correlation degree and, in principle, in an increased optical power per mode. In miniaturized quantum cascade lasers (QCLs), harmonic frequency combs (HFCs) are hence particularly attracting to explore quantum correlation effects between adjacent harmonic modes, enabled by the inherently large gain media third-order χ
(3) Kerr nonlinearity, even if controlled generation of stable HFCs of predefined order, is typically demanding in such electrically pumped sources. Here, we demonstrate stable 2nd order and 3rd order HFC emission in terahertz frequency QCLs by respectively patterning an individual or a couple of equally spaced distributed multilayer graphene absorbers on the top metallic waveguides.
AVALIAÇÃO DA EFICIÊNCIA DO CONTROLE DE TEMPERATURA EM SISTEMAS DE REFRIGERAÇÃO
Authors: Bentes Flavio Maldonado , Da Cruz Ferreira Cátia 
Published: February 2024

Os sistemas de ar condicionado de Vazão de Refrigerante Variável (VRF), atualmente, estão sendo mais utilizados em todo o mundo devido à procura por sistemas com uma eficiência mais aprimorada, que reflete diretamente a economia de energia elétrica. Dessa forma, neste trabalho propõe-se fazer uma análise do COP coeficiência de desenpenho dos sistemas convecional e VRF. Para tal objetivo, o sistema em estudo foi descrito através de um modelo matemático entre as unidades, sendo sua solução, originariamente para o sistema VRF.