bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined ultrasounds and CEA in preoperative assessment of hepatic metastases from gastrointestinal malignancies
Authors: Colizza S. , Lupattelli R. , De Fazio S. , Preziosi P. , Karakachi F. , Cucchiara G. 
Published: February 2007

AbstractA consecutive series of 100 patients affected by gastrointestinal malignancies entered a prospective controlled study of liver metastases performed by ultrasound echography, CEA, hepatic enzymes (only alkaline phospha‐tase (AP) was found to be somehow significant). Laparotomic inspection and palpation were taken as objective control of ultrasound scan. Eighteen out of the 100 patients showed diffuse hepatic metastases at surgery (all controlled histologically). Hepatic echography correctly diagnosed liver metastases in 15 out of these 18 patients ( = 83.8% sensitivity); two more cases (hepatic fibroangiomas) were interpreted as metastases (= 89.9% specificity). CEA‐RIA assay was pathologic (> 10 ng/ml) in all of the 18 patients with liver metastases; 21 out of the 82 without liver metastases were CEA positive (difference of mean values statistically significant at P < 0.01). The only significant hepatic enzyme was AP, which was pathologic in 12 out of 18 patients with liver metastases. The comparative evaluation of the three tests showed that ultrasound scanning missed three cases of diffuse hepatic metastases, which, however, were CEA positive, while AP could not help to correct such misdiagnosis.
Plasmacytoma of the parotid gland
Authors: Edney James A. , Thompson Jon S. , Conley Margaret C. , Moore George E. 
Published: February 2007

AbstractExtramedullary plasmacytoma of the parotid gland is an extremely rare lesion of which there have been only four other reported cases. The importance of these lesions rests in the possibility of their being a harbinger of multiple myeloma or their subsequent transformation to multiple myeloma. Because of its extreme rarity, the proper management remains unclear.
Carcinoma of the gallbladder: Autopsy findings in 287 cases and review of the literature
Authors: Sons H. U. , Borchard F. , Joel B. S. 
Published: February 2007

AbstractFrom 1950 to 1982, 287 patients with cancer of the gallbladder were autopsied. The ratio of men to women was 1:3.7. The average age of women was 70 years; that of men was 69.5 years. Most tumors (67.7%) had grown by diffuse infiltration and one‐third (32.3%) were polypous‐exophttic. Fundus and collum of the gallbladder showed an equal frequency (24%) of tumor localisation. The percentage of all gallbladder malignomas that were adenocarcinomas of various differentiation was 84.6, and 10.9% were anaplastic carcinomas, the rest consisted of squa‐mous cell carcinomas (3.7%) and 0.8% sarcomas. Metastases were found in 265 cases (92.3%). Tumorous infiltration, lymph node metastases, and visceral metastases are discussed. A cholelithiasis was found in 78.4%. The results are compared with the literature.
Levamisole in the treatment of glioblastoma multiforme
Authors: Fischer Sharon P. , Lindermuth John , Hash Cecil , Shenkin Henry A. 
Published: February 2007

AbstractTwenty‐five patients with malignant glioma were randomized to receive radiation therapy only or radiation therapy and oral Levamisole. There were no differences in survival between the two groups and therefore no advantage in the use of Levamisole in glioblastoma could be demonstrated.
Biopsy of bone tumours
Authors: Den Heeten C. J. , Oldhoff J. , Oosterhuis J. W. , Schraffordt Koops H. 
Published: February 2007

AbstractBone biopsy is not only the most important step in the diagnosis of bone tumours, but since the introduction of chemotherapy, it has also become essential in the evaluation of treatment of highly malignant bone tumours.A total of 206 bone biopsies were performed on 136 patients seen between January 1, 1978 and August 1, 1982 (99 open and 107 drill biopsies).Complications during or after biopsy were relatively rare, and none were of a serious nature. Pathological fractures at sites of biopsies developed exclusively in patients given chemotherapy. In gaining adequate histologic material, the overall result of open bone biopsies (98%) was superior to that of drill biopsies (70%). The choice between both techniques was dependent on individual patient factors. Of the total of 206 bone biopsies, 10% proved not to be representative.It is concluded that, especially in patients given chemotherapy for a malignant tumour of a long bone, the possibility of a spontaneous fracture after a bone biopsy should be borne in mind.
Prognostic value of preoperative serum CEA level compared to clinical staging: III. An approach to scoring of prognostic factors in colorectal cancer
Authors: Brümmendorf T. , Anderer F. A. , Staab H. J. , Hornung A. , Stumpf E. , Kieninger G. 
Published: February 2007

AbstractIn a clinical study of observed postoperative survival of colorectal cancer patients, we investigated the application of a risk score based on tumor‐related prognostic parameters. Six hundred seventy‐four patients have been registered for primary surgery of colorectal cancer since 1974 who did not receive further postoperative treatments. The prognostic parameters included operability, tumor extension, and preoperative serum carcinoembryonic antigen (CEA) level. The scoring system was based on the average death‐rate ratios of subgroups of patients and their age and sex‐matched reference groups derived from the general life table of the population of the Federal Republic of Germany. The individual score sums of the patients exhibited score sum ranges which characterized groups of patients with entirely different observed survival. The prediction of individual survival after primary operation was only partly possible. In the plot of individual survivals vs individual score sums, a marginal risk zone was obtained which evidently represents the zone of maximum expected survival of patients who do not receive further postoperative treatment.
Our experience with resection of primary and secondary liver tumours
Authors: Manfredi Dante , Campioni Norberto , Sorvillo Giovanni , Grauso Francesco , Romano Patrizio , Guglielmi Claudio , Sega Fabio Massimo 
Published: February 2007

AbstractThe authors retrospectively analyse the results achieved in recent years by surgical treatment of 103 malignant primary or secondary liver cancers: (Three patients have been operated on twice at different times for recurrence.) 23 hepatic resections were performed for benign lesions. The operative mortality is very low, the incidence of postoperative complications is minimal, and the survival up to 8 years is rather satisfactory. In all cases we used Ton That Tung's surgical technique, that is, “finger fracture with intraparenchymal ligature of the vasculobiliary pedicles.”.
What ultrasonography can tell in breast masses that mammography and physical examination cannot
Authors: Rosner Dutzu , Blaird Donna 
Published: February 2007

AbstractThe capability of ultrasonography to provide additional information to the physical and mammographic examination for therapeutic decision was investigated in a prospective study. Four hundred patients with palpable or radiologic breast masses requiring surgical biopsy were studied. The high resolution and accuracy of ultrasonography vs. mammography in the diagnosis of cystic masses (96%, 63/66 vs. 42%, 20/48) (p < 0.001) and fibrocystic masses (84%, 131/156 vs. 74%, 80/108) (p < 0.10), led to a substantial reduction of surgical biopsies in favor of aspiration or follow‐up policy, particularly when physical examination and mammography were inconclusive. Breast cancers were accurately diagnosed in 73% (88/ 120) by sonography and 84% (98/116) by mammography (p > 0.10). The major limitation of ultrasonography was noticed in the diagnosis of minimal breast cancer (23%, 5/21) due to its inability to visualize microcalci‐fications. Our study validates the importance of ultrasonography in the diagnosis and therapeutic decision of cystic and fibrocystic masses but cannot substitute mammography in early detection of breast carcinoma.
Continuous epidural narcotic analgesia for intractable pain due to malignancy
Authors: Yablonski‐Peretz T. , Klin B. , Beilin Y. , Warner E. , Baron S. , Olshwang D. , Catane R. 
Published: February 2007

AbstractEighty consecutive cancer patients with severe pain, uncontrolled by conventional narcotic analgesics, received a 2‐mg test dose of morphine epidurally. Thirty‐four of them had significant pain relief and were thus selected to receive continuous treatment. This consisted of 2–6 mg of morphine administered every 8–24 hours through an indwelling epidural catheter. The duration of treatment was from 1 to 28 weeks with a median of 4 weeks. Twenty‐five (76%) of the patients experienced complete relief of pain, while nine had only a partial analgesic response. Complications were minimal. No sepsis, hypotension, or respiratory depression occurred. It is recommended that cancer patients with intractable pain will be selected for continuous epidural analgesia by evaluating their response to a test dose of epidural morphine.
A clinical evaluation of carbohydrate antigen 19‐9 and carcinoembryonic antigen in patients with pancreatic carcinoma
Authors: Satake Katsusuke , Kanazawa Gakushu , Kho Ichikun , Chung Young‐Suk , Umeyama Kaoru 
Published: February 2007

AbstractWe have studied serum carbohydrate antigen 19‐9 (CA19‐9) and carcinoembryonic antigen (CEA) in 221 persons to assess their usefulness in the diagnosis of pancreatic carcinoma. Although serum CA19‐9 and CEA in all healthy controls were within normal limits, the positive ratings of serum CA19‐9 and CEA in all benign disease were 9.8% and 18.1%, respectively. Sensitivity of serum CA19‐9 for pancreatic carcinoma was 70.5%, which was higher than that found in healthy controls, benign disease, and other malignant disease except biliary carcinoma; but sensitivity of serum CEA levels (67.7%) was not different from that seen in malignant disease. Three of 34 patients (8.8%) with pancreatic carcinoma who had a above‐normal levels of serum CA19‐9 but not serum CEA were resectable. Although there was no correlation between serum CA19‐9 and CEA, advanced stages of pancreatic, gastric, and colorectal carcimoma tend to show high serum CA19‐9 and CEA, but no statistical differences were observed in relation to the stages of these carcinomas. Comparative studies of serum CA19‐9 and CEA for sensitivity and the predictive value of true positive and negative results for detecting pancreatic, gastric, and colorectal carcinoma showed that serum CA19‐9 has significantly higher sensitivity and predictive value of true positive results for pancreatic carcinoma than for gastric and colorectal carcinoma (P < 0.05). However, serum CEA measurements did not show any difference between these carcinomas, and the highest predictive value of a true negative result for excluding pancreatic carcinoma was also observed in serum CA19‐9. These results indicate that although the CA19‐9 assay is not specific for pancreatic carcinoma, it is a more useful adjunct method for diagnosing pancreatic carcinoma, possibly in resectable stages.
Heterogeneity of breast carcinomas determined by flow cytometric analysis
Authors: Prey Marianne U. , Meyer John S. , Stone Kenneth R. , McDivitt Robert W. 
Published: February 2007

AbstractEight cases of primary breast carcinoma were studied for evidence of heterogeneity by flow cytometry using propidium iodide staining of DNA. Tumors ranged from 2.5 to 8.0 cm in greatest dimension, mean 4.2 cm. Five to 11 samples, determined by tumor size, were analyzed from each primary tumor in addition to 4 axillary lymph nodal metastases from 3 of the 8 cases. The presence of carcinoma was demonstrated histologically in each flow cytometric sample. Three of the carcinomas showed only diploid DNA content. Three showed the same single hyperdiploid population in each sample. Two carcinomas (2.5 and 3.5 cm) were heterogeneous and demonstrated 2 or 3 hyperdiploid populations. The 2 or 3 distinct hyperdiploid populations were present singly or sometimes in combination in one sample. Five of the 11 samples from 1 of the heterogeneous tumors and its axillary metastasis contained a single diploid population. Therefore, flow cytometric analysis of a single sample from a breast carcinoma may not be representative of the entire tumor. The study of multiple samples of breast carcinomas by flow cytometry is necessary for full characterization of the tumors.
Immune status in advanced upper gastrointestinal cancers
Authors: Singh Gurpreet , Das S. N. , Khanna N. N. 
Published: February 2007

AbstractThirty‐eight cases of advanced upper gastrointestinal cancer were assessed for their immune status prior to any form of therapy. Cell‐mediated immunity, as tested by absolute lymphocyte count, T‐cell count and delayed cutaneous hypersensitivity reactions to purified protein derivative and phytohemagglutinin showed severe depression. Immunoglobulins A and M were elevated, while immunoglobulin G reduced. No correlation could be established between the immune status and the site of cancer or its extent, the performance status of the patients, or their response to chemotherapy.
Locally aggressive differentiated thyroid carcinoma
Authors: Tovi Ferit , Goldstein Jed 
Published: February 2007

AbstractLocal infiltration of adjacent anatomic structures and soft tissues of the neck from well‐differentiated carcinoma of the thyroid gland is a relatively infrequent occurrence. We report our experience with 21 such cases seen in our department over the past 20 years. All patients were treated by total thryoidectomy and total or partial excision of the infiltrated adjacent structures. Papillary carcinoma was the most frequent type of primary tumor seen. Following the definitive surgery, all patients were scanned with radioactive iodine (131I). In case of isotope entrapment, a curative dose 131I was given. All patients in our series were required to receive thyroid hormone replacement. Four patients died as a result of their disease. Uncontrolled local disease and distant metastases were present at the time of death. Three patients died of unrelated causes. Two‐thirds of the patients are still alive (from 1 to 19 years after the treatment).
Early‐stage rectal cancer: Electrofulguration in comparison to abdominoperineal extirpation or low‐anterior resection
Authors: De Graaf Peter W. , Roussel Jan G. , Gortzak Ernst , Hart Guus A. M. , Jongman Ans , Van Slooten Emil A. 
Published: February 2007

AbstractFor some small rectal cancers electrofulguration can be an attractive alternative to more extensive surgical procedures. This report is a review of 49 patients who, after careful selection, were considered ideal candidates for curative fulguration in the period 1959–1982. All had rectal adenocarcinomas and were clinically staged as Dukes' A tumors. To put the results of this analysis into perspective, they are compared to the results of those patients (34) who also had early clinical stage rectal adenocarcinomas, but for a variety of reasons underwent abdominoperineal excisions (APE, 11 patients) or low‐anterior resections (LAR, 23 patients) instead of fulguration. Postoperative complications after fulguration were minimal, there were no postoperative deaths, and all patients retained anal continence. After APE or LAR there were two postoperative deaths (one myocardial infarction, one ruptured iliac aneurysm); postoperative morbidity was greater. All LAR‐treated patients remained continent. Of the patients at risk 55% remained disease‐free after fulguration, while 77% remained disease‐free after APE or LAR (P = 0.023). This is due to a higher percentage of loco‐regional recurrences occurring after fulguration than after APE or LAR (31% vs 9%, respectively, P = 0.021). The percentage of patients with distant metastases in both groups are similar. It seems that electrofulguration of rectal cancers, even in strictly selected patients in a specialized institution, can lead to an unacceptably high percentage of patients with loco‐regional recurrences. Nearly all local failures occurred in patients with tumors that measured more than 3 cm in diameter and/or occupied more than one‐third of the rectal circumference. Salvage operations for loco‐regional failure were performed in 13 patients, 5 of whom are alive with no evidence of disease. Since there seems to be a direct relation between tumor size and the chance of loco‐regional recurrence and since salvage operations for local failure are not uniformly successful, electrofulguration for cure must be reserved for the very rare patient with a very small early‐stage rectal cancer.
Pyomyositis: A differential diagnosis from sarcoma
Authors: Reid Stephen E. , Nambisan Ramachandran , Karakousis Constantine P. 
Published: February 2007

AbstractA case of pyomyositis, a deep muscle abscess, presenting as a soft tissue sarcoma is reported. Although common in the tropics, this disease is quite rare in the United States. The presentation, diagnosis, and treatment of the problem are discussed and reviewed.
Surgical treatment of carcinoma of the breast, v. changes in patient population and therapeutic modalities at a metropolitan hospital (1971–1980)
Authors: Lee Yeu‐Tsu N. (Margaret) 
Published: February 2007

AbstractThis is a retrospective study of 408 patients who had mastectomy for carcinoma of the breast during 1971–1980. Over these 10 years, we have had a significant increase in Hispanic patients. Although the mean size of breast tumors among the Hispanic patients was smaller than that of our black patients, Hispanic patients are more likely to have higher numbers of positive axillary lymph nodes. Similar to the nationwide trend, over 90% of the patients had modified radical mastectomy in recent years, and adjuvant systemic chemotherapy has replaced postoperative radiotherapy for patients with axillary metastasis. Postmastectomy actuarial 5‐year relapse rates of our patients with none or 1–3 positive axillary nodes were quite similar. Among patients with 1–3 positive axillary nodes, year of diagnosis and whether postoperative radiotherapy or chemotherapy was added or not did not affect disease‐free probability. However, among patients who had four or more positive axillary nodes, those who were admitted after 1976 and who received systemic chemotherapy (90% had CMF) had a much lower probability of developing recurrence.
Squamous cell carcinoma of the stomach: A study of four patients with comments on histogenesis
Authors: Callery Charles D. , Sanders M. Melinda , Pratt Steven , Turnbull Alan D. 
Published: February 2007

AbstractThe histogenic origin of squamous carcinoma of the stomach (SCS) is controversial. We report the case of a 55‐year‐old man who developed SCS following successful chemotherapy for generalized well‐differentiated lymphocytic lymphoma. The patient's stomach contained both squamous carcinoma arising in squamous metaplasia and chronic atrophic gastritis with intestinal metaplasia. This case is compared to three additional cases of SCS where no such antecedent mucosal changes were evident. The SCS literature is reviewed and the histogenesis regarding the development of pure squamous tumors of the stomach is discussed.
Percutaneous subclavian catheterization for prolonged systemic chemotherapy
Authors: Thompson W. Raleigh , Alexander H. Richard , Martin Alfred J. , Fletcher J. Raymond , Ghosh Bimal C. 
Published: February 2007

AbstractRecent experience with 108 Broviac catheters was reviewed. Sixty‐eight were percutaneously placed in the subclavian veins of adults receiving systemic chemotherapy. For subclavian catheters perioperative and late complications were unusual. There was no pneumothorax or serious bleeding associated with insertion, even in severely thrombocytopenic patients. Mean catheter life was 93 days. Infection occurred in only five cases (7%). We conclude that percutaneous placement of right atrial catheters is a safe procedure which provides reliable access for prolonged chemotherapy in cancer patients.
Testicular neuroblastoma
Authors: Kellie Stewart J. , Waters Keith D. 
Published: February 2007

AbstractWe describe, in a young boy, a case of neuroblastoma presenting only as a painless unilateral testicular mass. Clinical and laboratory evidence of disseminated neuroblastoma was first apparent nine months after high orchiectomy. As far as we are aware this is the only reported instance of testicular neuroblastoma in the absence of disseminated disease. Discussion is directed to the possible explanations for this rare testicular lesion, and in addition, underlines the potential difficulties in the diagnosis of certain small cell tumors.
Prostatic carcinoma metastatic to bone: Sensitivity and specificity of prostate‐specific antigen and prostatic acid phosphatase in decalcified material
Authors: Shah Niranjan T. , Tuttle Steven E. , Storbel Stephan L. , Gandhi Leena 
Published: February 2007

AbstractDecalcified bone marrow biopsies containing metastatic tumor from 36 patients were stained for prostate‐specific antigen (PSA) and prostatic acid phosphatase (PAP) using the avidin biotin complex (ABC) immunoperoxidase technique. Of these patients, 22 had known prostate primaries, ten had known nonprostatic, and four female patients had unknown primaries. Prostate‐specific antigen was identified in 86% (19/22) of the metastatic prostatic carcinomas. Prostatic acid phosphatase was present in only 36% (8/22). None of the patients with nonprostatic primaries or unknown primaries showed positive staining for either antigen (0/14). This study indicates that immunoperoxidase staining for PSA is very sensitive and specific in the diagnosis of metastatic prostate carcinoma, while PAP was less sensitive using decalcified bone marrow specimens. We believe that immunostaining with PSA should be of great value in diagnosis of prostatic carcinoma metastatic to the bone.
Postoperative external irradiation in thyroid carcinoma: A clinical experience of 20 treated patients and literature radiotherapy review
Authors: Ampil Federico L. 
Published: February 2007

AbstractA retrospective review is presented of 20 evaluable patients who underwent surgical resection or biopsy for limited stage thyroid carcinoma at two institutions between 1963 and 1983. The majority had external radiotherapy to the whole neck and upper mediastinum and the total dose given varied from 3,800 to 6,000 rads. For group I (microscopic residual disease), 81.8% (9/11 patients) local control was observed during a follow‐up period of 2–75 months with adjuvant postoperative irradiation compared to surgery alone, 14.2% (1/7 patients) local control; 75% (9/12 patients) are alive and well. In group II (gross residual disease), local control was 25% (2/8 patients) and the survival was 14 and 60 months, respectively, with external radiotherapy. The beneficial external irradiation effects in terms of local control and survival even in some patients with gross unresectable disease are reiterated from this small series. A literature review summary of external radiotherapy results is also presented.
Progress in screening for early breast cancer
Authors: Baker Larry H. , Chin TOM D. Y. , Wagner Kay V. 
Published: February 2007

AbstractTen years have now passed since the American Cancer Society/National Cancer Institute sponsored Breast Cancer Detection Demonstration Projects (BCDDP) started to evaluate the use of mammography, physical examination, thermography, and breast self‐examination in screening women for the presence of unsuspected breast cancer. Criteria have been developed to evaluate population screening as an approach to cancer control and breast cancer screening techniques. Combined physical examination and mammography have been particularly successful in detecting early breast cancer. Although the number of screening programs for breast cancer has increased in the past decade, real progress has been surprisingly slow and the issues in breast cancer screening have proved to be subtle and complex.