bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic and Non-Genetic Factors Affecting Birth-Weight and Adult Body Mass Index
Authors: Whitfield John B. , Treloar Susan A. , Zhu Gu , Martin Nicholas G. 
Published: May 2007

AbstractBirthweight affects neonatal mortality and morbidity and has been used as a marker of foetal undernutrition in studies of prenatal effects on adult characteristics. It is potentially influenced by genetic and environmental influences on the mother, and effects of foetal genotype, which is partially derived from the maternal genotype. Interpretations of variation in birthweight and associated characteristics as being due to prenatal environment ignore other possible modes of materno-foetal transmission. Subjects were adult twins recruited through the Australian Twin Registry, aged 17 to 87 years, and the sample comprised 1820 men and 4048 women. Twins reported their own birthweight as part of a health questionnaire. Body Mass Index (BMI) was calculated from self-reports of height and weight. Correlations between co-twins' birthweights were high for both monozygotic (r = 0.77) and dizygotic (r = 0.67) pairs, leading to substantial estimates of shared environmental effects (56% of variance) with significant additive genetic (23%) and non-shared environmental (21%) components. Adult BMI was mainly influenced by genetic factors, both additive (36% of variance) and nonadditive (35%). The correlation between birthweight and BMI was positive, in that heavier babies became on average more obese adults. A bivariate model of birthweight and adult BMI showed significant positive genetic (rg = 0.16, p = 0.005) and environmental (re = 0.08, p = 0.000011) correlations. Intra-uterine environmental or perinatal influences shared by cotwins exercise a strong influence on birthweight, but the factors which affect both birthweight and adult BMI are partly genetic and partly non-shared environmental.
Perinatal Risk Factors for Hay Fever — A Study Among 2550 Finnish Twin Families
Authors: Räsänen Maija , Kaprio Jaakko , Laitinen Tarja , Winter Torsten , Koskenvuo Markku , Laitinen Lauri A. 
Published: May 2007

AbstractPrevious studies have suggested that perinatal factors influence the risk for asthma but population studies on perinatal factors and risk for hay fever are few. We studied the effect of perinatal factors on the risk for hay fever among adolescent twins by a questionnaire study involving five consecutive nation-wide birth cohorts of 16-year-old twins and their parents. The risk for parent-reported, doctor-diagnosed hay fever in the adolescents associated with several perinatal characteristics was assessed with logistic regression analysis among individuals and by a discordant pair analysis. In the univariate analysis of the birth factors, the risk for hay fever increased with increasing birth weight (pfor trend = 0.048, OR for those ≥ 3000g 1.35, 95% CI 0.91–2.02 compared to those < 2000g) and gestational age (pfor trend = 0.04, OR for those born after 40 weeks of gestation 2.24, 95% CI 1.03–4.86, compared to those born before 33 weeks of gestation) and was lower in those subjects hospitalised in the neonatal period (OR 0.74, 95% CI 0.58–0.93). Because of significant interactions between parental hay fever status and birth factors (ponderal index,p= 0.03 and maternal agep= 0.04), stratified analysis were performed. The positive association between birth weight and hay fever was most obvious among adolescents with no parental history of hay fever (pfor trend = 0.03). Similar, though not significant, trends were found with other birth factors among these families, whereas no such trend was found among adolescents with parental hay fever, suggesting that gestational maturity increases the risk for hay fever in the absence of genetic predisposition. However, of the perinatal factors only neonatal hospitalisation (OR 0.75, 95% CI 0.59–0.96) remained a significant risk factor for the development of hay fever, when adjusted for non-perinatal factors.
Birthweight and Body Mass Index in Young Adulthood: The Swedish Young Male Twins Study
Authors: Johansson Malin , Rasmussen Finn 
Published: May 2007

AbstractMany studies have found an inverse association between fetal growth and cardiovascular disease related to the metabolic syndrome in adulthood. Nevertheless, the relative importance of genetics and the intrauterine environment remain unclear. The objective of the study was to test the fetal origins hypothesis and the fetal insulin resistance hypothesis by studying the impact of fetal growth on Body Mass Index (BMI) in young adulthood. In a nationwide cohort study, the Swedish Medical Birth Register for the years 1973–1979 was linked with the Military Service Conscription Register for 1990–1999. In 1998 a questionnaire was mailed to all male twins, included in the two registers, who were alive and still resident in Sweden. The study covers the 923 male twin pairs for which full data were available. Mixed linear models were used to estimate within-pair and between-pair differences in birthweight and their relations to BMI. A weak positive association was found among the monozygotic twins for the withinpair difference in birthweight and BMI. No significant association was found among the monozygotic for the between-pair difference in birthweight and BMI. No significant associations were found for dizygotic twins. These findings do not seem to support either the fetal programming hypothesis or the fetal insulin resistance hypothesis.
Microscrew Anchorage in Skeletal Anterior Open-bite Treatment
Authors: Xun Chunlei , Zeng Xianglong , Wang Xing 
Published: May 2007

Abstract
Objective: To evaluate the effectiveness of miniscrew anchorage for intrusion of the posterior dentoalveolar region to correct skeletal open bite.
Materials and Methods: The study was comprised of 12 patients (aged 14.3 to 27.2 years; mean 18.7 years) with anterior open bites. All the patients presented a Class II skeletal pattern and excessive posterior growth. Self-drilling miniscrew implants were inserted into the posterior midpalatal area and the buccal alveolar bone between the lower molars. A transpalatal and a lingual arch were used to maintain the molars on each side in order to avoid overrotation during intrusion. A force of 150 g was applied to the microscrews on each side to intrude the posterior teeth. Lateral cephalograms of all 12 patients were taken preintrusion and immediately after completion of the intrusion. The cephalometric films were measured and compared.
Results: The results showed that the anterior open bites in 12 patients were all corrected in a mean of 6.8 months. Overbite increased by a mean of 4.2 mm (P &lt; .001), from −2.2 mm in preintrusion to 2.0 mm in postintrusion. The maxillary and mandibular first molars were intruded for an average of 1.8 mm (P &lt; .001) and 1.2 mm (P &lt; .001), respectively. The mandibular plane angle was reduced by 2.3° (P &lt; .001), which led to a counterclockwise rotation of the mandible with a significant decrease in the anterior facial heights (mean of 1.8 mm; P &lt; .001).
Conclusion: Miniscrew anchorage has the advantages of being a simpler procedure, being minimally invasive, and requiring minimal patient cooperation.
Dental Arch Widths and Mandibular-Maxillary Base Width in Class III Malocclusions with Low, Average and High MP-SN Angles
Authors: Chen Fengshan , Terada Kazuto , Wu Liping , Saito Isao 
Published: May 2007

Abstract
Objective: To analyze the development of the dental arches and skeletal mandibular-maxillary bases in untreated Class III malocclusions with low averages and high mandibular plane angles in subjects aged 10 to 14.
Materials and Methods: The records of 50 untreated Japanese girls with Class III malocclusions at age 10 were selected from the files of patients pending orthodontic surgery. The patients included those with low (≤27°), average (27° through 37°) and high (&gt;37°) mandibular plane angles. The maxillary skeletal base width, biantegonial width, and maxillary and mandibular intermolar width were determined on posteroanterior cephalograms obtained at annual intervals when subjects were between 10 and 14 years of age. The difference between the maxillary and mandibular intermolar width was also calculated and reported.
Results: All skeletal and dental transverse widths in the high-angle group were significantly smaller than those in the low-angle group (P &lt; .05) from ages 10 to 14. On the other hand, the maxillary to mandibular molar difference was the same for the three groups (P &gt; .05) at each age. The deviations in molar differences did increase from age 10 to age 14 in all three groups.
Conclusion: Mandibular plane angles might play a stronger role in the transverse skeletal growth of the maxilla and the mandible than the transverse dental growth of the maxilla and the mandible.
Long-term Stability of Orthodontic Treatment and Patient Satisfaction
Authors: Bondemark L. , Holm Anna-Karin , Hansen Ken , Axelsson Susanna , Mohlin Bengt , Brattstrom Viveka , Paulin Gunnar , Pietila Terttu 
Published: May 2007

AbstractObjective: To evaluate morphologic stability and patient satisfaction at least 5 years after orthodontic treatment.Materials and Methods: Published literature was searched through the PubMed and Cochrane Library electronic databases from 1966 to January 2005. The search was performed by an information specialist at the Swedish Council on Technology Assessment in Health Care. The inclusion criteria consisted of a follow-up period of at least 5 years postretention; randomized clinical trials, prospective or retrospective clinical controlled studies, and cohort studies; and orthodontic treatment including fixed or removable appliances, selective grinding, or extractions. Two reviewers extracted the data independently and also assessed the quality of the studies.Results: The search strategy resulted in 1004 abstracts or full-text articles, of which 38 met the inclusion criteria. Treatment of crowding resulted in successful dental alignment. However, the mandibular arch length and width gradually decreased, and crowding of the lower anterior teeth reoccurred postretention. This condition was unpredictable at the individual level (limited evidence). Treatment of Angle Class II division 1 malocclusion with Herbst appliance normalized the occlusion. Relapse occurred but could not be predicted at the individual level (limited evidence). The scientific evidence was insufficient for conclusions on treatment of cross-bite, Angle Class III, open bite, and various other malocclusions as well as on patient satisfaction in a long-term perspective.Conclusions: This review has exposed the difficulties in drawing meaningful evidence-based conclusions often because of the inherent problems of retrospective and uncontrolled study design.
Maxillary Canine—First Premolar Transposition
Authors: Capelozza Filho Leopoldino , Cardoso Mauriciode Almeida , An Tien Li , Bertoz Francisco Antonio 
Published: May 2007

Abstract
Tooth transpositions present at a relatively low incidence in the world population and primarily affect maxillary canines and premolars. Treatment of this disturbance should take into account aspects such as facial pattern, age, malocclusion, tooth-size discrepancy, stage of eruption, and magnitude of the transposition. Mechanics for correction should be entirely individualized, reducing the risks and adverse effects. Practitioners often select simpler options, indicating extraction of permanent teeth, which is an irreversible procedure that may bring about damages to the patient. This study presents a case report and treatment of unilateral transposition of maxillary canine and premolar with repositioning of affected teeth to their respective normal positions.
Unusual Extraction Treatment in Class II division 1 Using C-Orthodontic Mini-Implants
Authors: Chung Kyu-Rhim , Cho Jae-Hee , Kim Seong-Hun , Kook Yoon-Ah , Cozzani Mauro 
Published: May 2007

AbstractThis paper describes the treatment of a female patient, aged 23 years and 5 months, with a Class II division 1 malocclusion, who showed severe anterior protrusion and lower anterior crowding. Specially-designed orthodontic mini-implants were placed bilaterally in the interdental space between both the upper and the lower posterior teeth. Both lower first molars showed severe apical lesions. Therefore, the treatment plan consisted of extraction of both upper first premolars and lower first molars, en masse retraction of the upper six anterior teeth, lower anterior alignment, and protraction of all the lower molars. C-implants® were used as substitutes for maxillary posterior anchorage teeth during anterior retraction and as hooks for mandibular molar protraction. The correct overbite and overjet were obtained by intruding and retracting the upper six anterior teeth into their proper positions. The dentition was detailed using conventional orthodontic appliances. The upper C-implants contributed to an improvement in facial balance, and the lower C-implants made it possible to protract the lower second and third molars with less effect on the axis of the lower anterior teeth. The active treatment period was 29 months and the patient's teeth continued to be stable 11 months after debonding.
Chinese Norms of McNamara's Cephalometric Analysis
Authors: Wu John , Hägg Urban , Rabie A. Bakr M. 
Published: May 2007

Abstract
Objective: To establish cephalometric norms of McNamara's analysis in young Chinese and compare them to those of a matched young Caucasian sample.
Materials and Methods: The material comprised lateral cephalometric radiographs of a random sample of 200 male and 205 female 12-year-old southern Chinese children, and an additional sample of 43 male and 43 female 12-year-old British Caucasian children in Hong Kong. The radiographs were digitized twice with the CASSOS program.
Results: The results showed that there were statistically significant gender differences for six out of the 11 cephalometric variables in the Chinese, but for only one variable in the Caucasians. The size of the statistically significant gender differences varied from −0.3 to 0.4 on SD scores. There were statistically significant ethnic differences for eight variables in males and seven variables in females. The size of the observed statistically significant ethnic differences varied from −1.8 to 1.6 on SD scores.
Conclusion: The use of specific standards for Chinese, separate for gender, for McNamara's cephalometric analysis seems to be justified.
Tooth Size Discrepancies in an Orthodontic Population
Authors: Othman Siti , Harradine Nigel 
Published: May 2007

Abstract
Objective: To explore how many millimeters of tooth size discrepancy (TSD) are clinically significant, to determine what percentage of a representative orthodontic population has such a tooth size discrepancy, and to determine the ability of simple visual inspection to detect such a discrepancy.
Materials and Methods: The sample comprised 150 pretreatment study casts with fully erupted and complete permanent dentitions from first molar to first molar, which were selected randomly from 1100 consecutively treated white orthodontic patients. The mesiodistal diameter tooth sizes were measured using digital calipers, and the Bolton analysis and the tooth size corrections were calculated by the Hamilton Arch Tooth System (HATS) software. Simple visual estimation of Bolton discrepancy was also performed.
Results: In the sample group 17.4% had anterior tooth-width ratios and 5.4% had total arch ratios greater than 2 of Bolton's standard deviations from Bolton's mean. For the anterior analysis, correction greater than ± 2 mm was required for 16% of patients in the upper arch or 9% in the lower arch. For the total arch analysis, the corresponding figures are 28% and 24%.
Conclusions: It is recommended that 2 mm of required tooth size correction is an appropriate threshold for clinical significance. A significant percentage of patients have a TSD of this size. Visual estimation of TSD has low sensitivity and specificity. Careful measurement is more frequently required in clinical practice than visual estimation would suggest.
Intrusion of Overerupted Upper First Molar Using Two Orthodontic Miniscrews
Authors: Kravitz Neal D. , Kusnoto Budi , Tsay Peter T. , Hohlt William F. 
Published: May 2007

AbstractLoss of the mandibular first molar often leads to the overeruption of the opposing maxillary first molar, resulting in occlusal interference, loss of periodontal bony support, and inadequate room to restore the mandibular edentulous space. Without orthodontic molar intrusion or segmental surgical impaction, restoring the posterior occlusion often entails the need for significant reduction of maxillary molar crown height, with the potential need for costly iatrogenic root canal therapy and restoration. The literature has cited successful maxillary molar intrusion with minor prosthodontic reduction using palatal orthodontic miniscrews and buccal zygomatic miniplates. In this report, the authors present successful maxillary molar intrusion with two orthodontic miniscrews in a patient with extreme dental anxiety and significant dental erosion due to gastric reflux. Using two orthodontic miniscrews for skeletal anchorage to intrude the maxillary molar simplified the orthodontic treatment by eliminating the need for extensive surgery, headgear, and intraoral multiunit anchorage and preserved indispensable tooth enamel. The clinical results showed significant intrusion through the maxillary sinus cortical floor while maintaining periodontal health, tooth vitality, and root length.
Three-Dimensional Palatal Development between 3 and 6 Years
Authors: Ciusa Veronica , Dimaggio Francesca Romana , Sforza Chiarella , Ferrario Virgilio Ferruccio 
Published: May 2007

Abstract
Objective: To measure palatal landmarks of healthy nonpatient children aged 3 to 6 years with a normal deciduous dentition and to evaluate palatal shape independent of size.
Materials and Methods: Fifty-eight dental casts of children with a normal and complete deciduous dentition were obtained and digitized with a computerized 3D instrument. At all ages, male and female data did not differ (Student's t-test), so the pooled values were considered. Dimensions were compared between ages by analyses of variance.
Results: Palatal slope and height increased significantly as a function of age (P &lt; .001). Palatal length did not change with age (average: 23.1 mm). In the frontal plane, the intermolar width increased slightly with age by about 1.8 mm at the second molars, 1.1 mm at the first molars, and 0.9 mm at the canines. Palatal height in the frontal plane did not change in the posterior part of the palate, but decreased anteriorly. The intercanine distance increased by 0.9 mm with age. However, this change did not reach statistical significance.
Conclusions: Between 3 and 6 years of age, palatal shape changed and became proportionally higher in both the frontal and sagittal planes.
Periodontal Ligament Hydrostatic Pressure with Areas of Root Resorption after Application of a Continuous Torque Moment
Authors: Hohmann Ansgar , Wolfram Uwe , Geiger Martin , Boryor Andrew , Sander Christian , Faltin Rolf , Faltin Kurt , Sander Franz Guenter 
Published: May 2007

Abstract
Objective: To evaluate the risk of root resorption, individual finite element models (FEMs) of extracted human maxillary first premolars were created, and the distribution of the hydrostatic pressure in the periodontal ligament (PDL) of these models was simulated.
Materials and Methods: A continuous lingual torque of 3 Nmm and 6 Nmm respectively was applied in vivo to the aforementioned teeth. After extraction, FEMs of these double-rooted teeth were created based on high-resolution microcomputed tomographics (micro CT, voxel size: 35 microns). This high volumetric resolution made the recognition of very small resorption lacunae possible. Scanning electron micrographs of the root surfaces were created as well. This enabled the investigation of advantages and disadvantages of the different imaging techniques from the viewpoint of the examination of root resorption. Using the FEMs, the same loading conditions as applied in vivo were simulated.
Results: The results of clinical examination and simulations were compared using the identical roots of the teeth. The regions that showed increased hydrostatic pressure (&gt;0.0047 MPa) correlated well with the locations of root resorption for each tooth. Increased torque resulted in increased high-pressure areas and increased magnitudes of hydrostatic pressure, correlating with the experiments.
Conclusion: If hydrostatic pressure exceeds typical human capillary blood pressure in the PDL, the risk of root resorption increases.
Glenoid Fossa Responses to Mandibular Lateral Shift in Growing Rats
Authors: Liu Chang , Kaneko Sawa , Soma Kunimichi 
Published: May 2007

Abstract
Objective: To evaluate the morphological and histological responses of the glenoid fossa to mandibular lateral shift in growing rats.
Materials and Methods: A resin plate was placed on the upper incisors of 4-week-old rats in the experimental groups to displace the mandible to the left during closure. The rats were killed after 2, 4, 8, and 12 weeks. The morphometric measurements were performed on dry skulls, and tissue blocks were processed for periodic acid and Schiff's reagent (PAS) staining to examine the new bone formation.
Results: Gross measurements showed asymmetry in both the position and size of the fossae between the two sides after 4 weeks of lateral shift. The glenoid fossa on the ipsilateral side was repositioned relatively backward, outward and upward compared with the contralateral side and control group, whereas the fossa on the contralateral side was relocated relatively forward and downward compared with the control group. The length of the fossa was smaller on the ipsilateral side than on contralateral side and control group. At 2 weeks, the amount of newly formed bone in the posterior region of the fossa was higher in the experimental group than the control group.
Conclusion: It is suggested that the mandibular lateral shift causes asymmetry in the position and size of the glenoid fossa and that this phenomenon can be related to different bilateral directional new bone formation in the posterior region.
Proportional Analysis of Longitudinal Craniofacial Growth Using Modified Mesh Diagrams
Authors: Jiang Jiuhui , Xu Tianmin , Lin Jiuxiang , Harris Edward F. 
Published: May 2007

Abstract
Objective: To study the craniofacial changes of adolescents followed longitudinally with their heads oriented in natural head position.
Materials and Methods: Longitudinal cephalograms of adolescents (n = 28) with normal occlusion, selected from among 900 candidates, were taken at 13 and again at 18 years of age. Modified elaborate mesh diagrams were developed defined by 90 anatomic landmarks and an additional 172 interpolated points for each cephalogram using a preset computer program. Detailed proportional and disproportional craniofacial changes were showed by both statistical and graphical methods.
Results: In females, most craniofacial regions exhibited growth that was proportionate to the mesh core rectangle reference on extracranial true vertical. In males, there was an upward, disproportional enhanced shift of the anterior cranial base and a downward enhanced shift of the mandibular symphysis and inferior border of the corpus.
Conclusions: This elaborate mesh analysis, based on mesh core rectangle and referenced on estimated natural head position, provides a novel graphical as well as quantitative method of assessing craniofacial growth. From 13 to 18 years of age, two sexes with normal occlusion displayed different growth patterns referenced on estimated natural head position. In females, most craniofacial regions exhibited growth proportional to the mesh core rectangle. In males, there was an upward, enhanced shift of the anterior cranial base and a downward enhanced shift of the mandibular symphysis and inferior border of the corpus.