bluuebunny/crossref_metadata_2025_split huggingface dataset:
PREVALENCE, RISK FACTOR, MANAGEMENT AND OUTCOME OF RESISTANT HYPERTENSION: SYSTEMATIC REVIEW
Authors: Azwar Aziz Mohamad , Intan Kania Yulia , Aziz Ilham , Sibli  
Published: March 2024

Background: Resistant hypertension (RH) increases the morbidity and mortality from stroke and cardiovascular disease in comparison to hypertension without treatment resistance.
Aims : This systematic review is to review the prevalence, risk factor and management of resistant hypertension.
Methods: This study demonstrated compliance with all requirements by means of a comparison with the standards established by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020. Thus, the specialists were able to guarantee that the research was as current as feasible. Publications released between 2014 and 2024 were considered for this search strategy. This was accomplished by utilizing a number of distinct online reference sites, including Pubmed, ScienceDirect, and SagePub. It was determined that reviews, previously published works, and partially completed works would not be included.
Result: In the PubMed database, the results of our search brought up 1032 articles, whereas the results of our search on SAGEPUB brought up 29093 articles, our search on SCIENCE DIRECT brought up 96059 articles. The results of the search conducted for the last year of 2014 yielded a total 556 articles for PubMed, 12517 articles for SAGEPUB and 43884 articles for SCIENCE DIRECT. In the end, we compiled a total of 9 papers, 4 of which came from PubMed, 1 of which came from SAGEPUB and 4 of which came from SCIENCE DIRECT. We included nine research that met the criteria.
Conclusion: In summary, the therapy of lowered heart rate includes improving lifestyle modifications, utilizing long-acting thiazide-like diuretics, adding a mineralocorticoid receptor antagonist, and gradually adding antihypertensive drugs with complementary modes of action if blood pressure does not decline.
Bienestar social y calidad de vida
Authors: González Navarro Sebastiana 
Published: March 2024

El bienestar y la calidad de vida son indicadores que podo a coco han empezado a usarse de manera más frecuente en la sociedad moderna, sin que haya un patrón claro tan siquiera para definición, sino que dependen en gran medida del sistema cultural y económico que esté instaurado, lo cual conlleva a que no haya unos mecanismos claros de medicación. Es necesario determinar sus dimensiones y los instrumentos más utilizados, para que así los profesionales del Trabajo Social puedan usarlos de manera adecuada a los diferentes perfiles de los usuarios, hasta que desde las instituciones den unas directrices claras que los delimiten. Para ello haremos un estudio de las escalas de medición más usadas, viendo sus pros y sus contras en las diferentes áreas de intervención (residencias de ancianos, centros escolares, atención infantil temprana, etc.) con el fin de encontrar un matriz común que sirva de modelo metodológico, práctico y de fácil uso.
Funciones profesionales de los trabajadores sociales, hoy
Authors: Bautista Miranda Miguel , Jiménez Amador Vasti Zurisadai , Sánchez Villal Martín 
Published: March 2024

El presente artículo tiene por objetivo analizar las funciones profesionales inherentes al trabajo social. Las categorías de análisis que se abordaron son la investigación social, la planeación y programación social, la ejecución social, la evaluación de planes, programas y proyectos sociales y, la sistematización de la experiencia profesional. Es un estudio documental, toda vez que se recurrió a la búsqueda de información impresa y digital en libros y artículos especializados de trabajo social.
Los resultados permiten visibilizar que las funciones profesionales sustantivas de trabajo social están vinculadas a las metodologías propias de la disciplina y profesión. Funciones que tienen una regularidad significativa en el saber-hacer profesional indistintamente del área y campo de intervención. Además, se encontró que en los contextos actuales se han gestado funciones profesionales emergentes como la peritación, la mediación social, la intervención en crisis, cuidados paliativos, la tanatología, el acompañamiento social, la educación para la paz, el emprendimiento social, la construcción de la ciudadanía, la intervención democrática, educación de género y en derechos humanos, educación ambiental, intervención con migrantes, por mencionar algunas. Haceres profesionales que requieren ser teorizados e incorporados en las curriculas de trabajo social a nivel licenciatura y posgrado.
Pelatihan Peningkatan Keterampilan Bahasa Inggris bagi Pemandu Wisata Kawasan Agro Wisata Rekadana Kabupaten Kubu Raya
Authors: Dian Shinta Sari  
Published: March 2024

Tujuan dari Kegiatan Pengabdian Kepada Masyarakta (PKM) yang dilaksanakan di Kabupaten Kubu Raya, Desa Jeruju Besar kawasan agro wisata Rekadana Kalimantan Barat untuk meningkatkan dan mengoptimalkan kemampuan yang dimiliki oleh para pemandu wisata dalam berkomunikasi dalam bahasa Inggris dengan wisatawan asing di daerah tersebut. Pelatihan ini melibatkan para pemandu wisata dan pelaku wisata di kawasan tersebut yang berjumlah 20 orang. Para peserta tersebut belum memiliki keterampilan Bahasa Inggris yang memadai dan kurangnya jumlah pemandu wisata yang dapat berbicara Bahasa Inggris. Metode dalam kegiatan ini menggunakan metode ceramah, diskusi kelompok, demonstrasi, presentasi personal, dan bermain peran serta tanya jawab. Setelah mengikuti kegiatan ini, ada peningkatan kemampuan dan kepercayaan diri dalam berintereaksi menggunakan bahasa Inggris aktif dari para pemandu wisata tersebut. Hal ini ditunjukkan dari hasil peningkatan yang di dapat dari nilai post test dengan nilai rata-rata 77,5. Dari hasil tersebut membuktikan bahwa para pemandu wisata dapat memaksimalkan potensi dan kemampuan mereka untuk berbicara memakai bahasa Inggris.
RESET Alcohol: A Global Alcohol Policy Initiative
Authors: Drope Jacqui 
Published: March 2024

The RESET Alcohol initiative supports national governments in low- and middle-income countries to implement three policy actions from the World Health Organization SAFER technical package: increasing taxation, regulating availability, and restricting marketing. RESET Alcohol is working in up to 15 countries primarily in Latin America, Africa, and Asia and is led by Vital Strategies, a global public health organization, in partnership with University of Illinois Chicago Tobacconomics, Movendi International, Global Alcohol Policy Alliance, NCD Alliance and the World Health Organization. The initiative is funded by the grantmaking organization Open Philanthropy. This article provides an overview of the initiative and the countries’ progress in its first year of implementation.
Randomized, Single Blind, Standard Controlled, Equivalence Clinical Trial to Evaluate the Comparative Efficacy of Eladi Kasaya Versus Tranexamic Acid Tablet in the Management of Asrigdara (Heavy Menstrual Bleeding): A Clinical Trial Protocol
Authors: Agrawal Trapti , Inamdar Saunitra , Panigrahi Hemanta Kumar , Rathod Pratiksha 
Published: March 2024

Introduction: Excessive menstrual bleeding is a common problem in reproductive age group females, and it is reported that 1 in 20 lifetime chances, a female needs consulting the physician for excessive and prolonged menstrual bleeding. Ayurvedic literature describes excessive menstrual bleeding as Asrigdara (HMB). Eladi kasaya is one of the treatment modalities for heavy menstrual bleeding given in classics and hence chosen for the current clinical trial.
Methods: We planned a prospective, randomized, controlled, and equivalence trial on the patients with Heavy menstrual bleeding (blood loss > 80 ml) for the last two cycles or more. Eladi Kasaya 50 ml with honey and sharkara(sugar) thrice a day will be given from day 1 to day 7 for 3 consecutive menstrual cycles to Group A and Tablet Tranexamic acid 500mg thrice a day to Group B. Primary outcome measures are menstrual blood loss improvement, reduction in pain assessed by visual analog scale, and change in Haemoglobin concentration. The secondary outcome measure is improvement in quality of life. All adverse drug reactions will be monitored and reported to Ayush Suraksha, pharmacovigilance center, Maharashtra. Following sample size calculation 46 patients will be recruited in each group to demonstrate equivalence with 80% power. The duration of study will be 2 years. The study is approved through Institutional Ethics Committee dated 07/10/2022, MGACHRC/IEC/Oct-2022/585. Participant recruitment shall be started after getting registered with the Clinical Trial Registry of India.
Results: Current manuscript is a clinical protocol, hence results are yet to derive from the study. Results will be presented in conferences and shall be attempted to publish in indexed/peer-reviewed medical journals.
Conclusion: Conclusion shall be drawn after completion of the clinical study.
Borate as a Phosphate Ester Mimic in Aldolase‐Catalyzed Reactions: Practical Synthesis of L‐Fructose and L‐Iminocyclitols
Authors: Sugiyama Masakazu , Hong Zhangyong , Whalen Lisa J. , Greenberg William A. , Wong Chi‐Huey 
Published: December 2006

AbstractDihydroxyacetone phosphate (DHAP)‐dependent aldolases have been widely used for the organic synthesis of unnatural sugars or derivatives. The practicality of using DHAP‐dependent aldolases is limited by their strict substrate specificity and the high cost and instability of DHAP. Here we report that the DHAP‐dependent aldolase L‐rhamnulose 1‐phosphate aldolase (RhaD) accepts dihydroxyacetone (DHA) as a donor substrate in the presence of borate buffer, presumably by reversible in situ formation of DHA borate ester. The reaction appears to be irreversible, with the products thermodynamically trapped as borate complexes. We have applied this discovery to develop a practical one‐step synthesis of the non‐caloric sweetener L‐fructose. L‐Fructose was synthesized from racemic glyceraldehyde and DHA in the presence of RhaD and borate in 92 % yield on a gram scale. We also synthesized a series of L‐iminocyclitols, which are potential glycosidase inhibitors, in only two steps.
Bismuth‐ and Hafnium‐Catalyzed Hydroamination of Vinyl Arenes with Sulfonamides, Carbamates, and Carboxamides
Authors: Qin Hongbo , Yamagiwa Noriyuki , Matsunaga Shigeki , Shibasaki Masakatsu 
Published: December 2006

AbstractCatalytic intermolecular hydroamination of vinyl arenes is described. Our initial investigation revealed that a Bi(OTf)3/[Cu(CH3CN)4]PF6 system previously developed for catalytic intermolecular hydroamination of 1,3‐dienes was suitable for hydroamination of a styrene with sulfonamides, but the substrate generality of this system was unsatisfactory. Several metals were screened to expand the substrate scope, and a new Hf(OTf)4/[Cu(CH3CN)4]PF6 system was determined to be highly suitable. The combination of Hf(OTf)4 and [Cu(CH3CN)4]PF6 efficiently promoted the hydroamination of various vinyl arenes, including less‐reactive vinyl arenes with electron‐withdrawing groups. This strategy was applied to sulfonamides, carbamates, and carboxamides, and products were obtained in up to 99 % yield with 0.3–10 mol % catalyst loading.
Effect of omeprazole on the pharmacokinetics of paricalcitol in healthy subjects
Authors: Palaparthy Rameshraja , Pradhan Rajendra S. , Chan Jenny , Rieser Matthew , Chira Titus , Galitz Lawrence , Awni Walid , Williams Laura A. 
Published: December 2006

AbstractParicalcitol capsules are indicated for the prevention and treatment of secondary hyperparathyroidism in chronic kidney disease (CKD). Proton pump inhibitors are prescribed to CKD patients to treat gastroesophageal reflux. This was a single dose, crossover study evaluating the effect of omeprazole, change in gastric pH as a result thereof, on the pharmacokinetics (PK) of paricalcitol. Twenty‐six healthy subjects were administered paricalcitol capsules (16 µg) alone (regimen A), and following a single dose of OMP (40 mg) (regimen B), with a washout of at least 7 days. Plasma samples for paricalcitol concentrations were collected for 48 h post‐paricalcitol dose. The plasma paricalcitol concentrations were measured using an LC–MS/MS assay (LOQ=0.02 ng/ml) and paricalcitol pharmacokinetic parameters were estimated using non‐compartmental methods. The point estimates and the corresponding 90% confidence intervals for Cmax and AUC0‐∞ to evaluate paricalcitol–omeprazole interaction were 1.032 [0.920–1.158] and 1.041 [0.951–1.139], respectively. No significant differences in Tmax (regimen A: 2.9 h vs regimen B: 2.6 h) or t1/2 (6.83 h vs 6.6 h) between the regimens were observed. Hence, the co‐administration of omeprazole does not affect the PK of paricalcitol. Both regimens were well tolerated and no apparent differences among the regimens with respect to safety were observed. Copyright © 2007 John Wiley & Sons, Ltd.
Co‐operating and communicating: a European perspective on integrating services for children
Authors: Katz Ilan , Hetherington Rachael 
Published: December 2006

AbstractThis paper looks at the range of differences within European child protection systems and considers the relationship between different approaches and the integration of children and family services. A distinction is made between structures that are child and family welfare focused, and those that are child protection focused. Some of the different structures of service delivery are described and the effect of these structures on the roles of the main stakeholders (and therefore on integration of services) is considered. Reference is made to a practice‐based research project that considered co‐operation and communication between health and welfare services in 12 countries. This research provides examples of different ways of integrating services and encouraging co‐operation.It is not possible to construct ‘league tables’ of best performing structures and services cross‐nationally because there are no reliably comparable statistics, but the research project gave indications of the factors that contributed to better communication and to better outcomes. Structure did not seem to be of primary importance, though it might help or hinder. However, with co‐operation, very different structures could work effectively. In general, high levels of material resources helped. However, professional time was the most important resource, because time was needed to develop effective working relationships with other professionals. The factors that facilitated good interdisciplinary and interagency work point to the centrality of a professional and managerial culture that values the development of good working relationships both with families and with other professionals. Conflictual and defensive inter‐professional relationships created problems, however well organized the system. Copyright © 2006 John Wiley & Sons, Ltd.
Studies of a Cobalt(III) Complex of the MMP Inhibitor Marimastat: A Potential Hypoxia‐Activated Prodrug
Authors: Failes Timothy W. , Cullinane Carleen , Diakos Connie I. , Yamamoto Natsuho , Lyons J. Guy , Hambley Trevor W. 
Published: December 2006

AbstractWe report a potential means of selectively delivering matrix metalloproteinase (MMP) inhibitors to target tumour sites by use of a bioreductively activated CoIII carrier system. The carrier, comprising a CoIII complex of the tripodal ligand tris(methylpyridyl)amine (tpa), was investigated with the antimetastatic MMP inhibitor marimastat (mmstH2). The X‐ray crystal structure of [Co(mmst)(tpa)]ClO4⋅4 H2O was determined and two‐dimensional NMR revealed the existence of two isomeric forms of the complex in solution. Electrochemical analysis showed that the reduction potential of the complex is suitable for it to be bioreductively activated at hypoxic tumour sites. In vitro assays confirmed the stability of the prodrug in solution prior to reduction and revealed very low cytotoxicity against A2780 cells. In vivo testing in mice showed a higher level of tumour‐growth inhibition by the complex than by free marimastat. Both free marimastat and and its CoIII complex increased metastasis in the model used, with the complex significantly more active.
Free‐Radical Pathways in the Decomposition of Ketones over Polycrystalline TiO2: The Role of Organoperoxy Radicals
Authors: Carter Emma , Carley Albert F. , Murphy Damien M. 
Published: December 2006

AbstractThe oxidative decomposition of various ketones (including acetone, 2‐butanone, 4‐heptanone, cyclopentanone and cyclohexanone) over dehydrated TiO2 (P25) powder is investigated by electron paramagnetic resonance (EPR) spectroscopy. For the first time, a series of thermally unstable radical intermediates are observed both on the activated and reduced TiO2 surface, depending on the adopted experimental conditions. These radical intermediates are identified as organoperoxy‐based species of general formula ROO. and RCO3.. They are formed by reaction of photogenerated charge carriers (either trapped electrons or trapped holes) with the adsorbed ketones in the presence of molecular oxygen. The organoperoxy intermediates are thermally unstable and decompose at temperatures in the region of 180–250 K. This work demonstrates that free‐radical pathways involving both organoperoxy and superoxide radicals can be responsible for the thermal‐ and photodecomposition of ketones over polycrystalline TiO2 (P25).
Treatment intensity and regularity in early outpatient psychotherapy and its relation to outcome
Authors: Kraft Susanne , Puschner Bernd , Kordy Hans 
Published: December 2006

AbstractThe distribution of treatment sessions (number of interruptions, weeks without psychotherapy and number of sessions) during the first three months of psychodynamic psychotherapy (PD), cognitive behavioral therapy (CBT) and psychoanalytic psychotherapy (PAP) was analyzed prospectively over two years in a sample of 256 outpatients.Number of weeks without psychotherapy in early treatment was predicted by initial helping alliance in PD and by initial quality of interpersonal relations in CBT. Level of initial psychological or physical impairment showed no effect on distribution of sessions during early treatment. In PD and CBT, session distribution early in treatment did not predict subsequent course of improvement. Only in PAP did weeks without psychotherapy and number of sessions affect rate of symptom change, in that participants showed better outcome when treatment started continuously at a rather slow pace. Implications for psychotherapy practice and research are discussed. Copyright © 2006 John Wiley & Sons, Ltd.
Atypical squamous cells, cannot exclude high grade intraepithelial lesion (ASC‐H): Does HPV matter?
Authors: Reid‐Nicholson Michelle , Gatscha Rose Marie , Riedel Elyn R. , Lin Oscar 
Published: December 2006

AbstractThe role of human papillomavirus (HPV) in cases diagnosed as atypical squamous cells, cannot exclude high squamous grade intraepithelial lesion (ASC‐H) in cervical specimens is not well established. The objective of this study is to evaluate the role of HPV status in cases of ASC‐H in a major cancer center. One hundred thirty‐two patients with a diagnosis of ASC‐H were identified over a 4‐yr period in our institution. Forty–four of 132 cases were evaluated for high‐risk HPV and had biopsy follow‐up. The positive predictive value (PPV) of ASC‐H for high‐grade squamous intraepithelial lesions overall was 32% while PPV of ASC‐H with associated HR HPV was 42%. This increase was statistically significant with P = 0.003 and suggest that HPV testing might be useful to increase the PPV of ASC‐H. Diagn. Cytopathol. 2007;35:1–5. © 2006 Wiley‐Liss, Inc.
Review of Penner's criteria for proficiency testing in cytopathology: Implications for the redesign of the federally mandated proficiency testing in cytopathology
Authors: Nagy George K. , Newton Louise E. 
Published: December 2006

AbstractThirty‐three years ago Penner advocated six criteria for the performance of proficiency testing in cytopathology (PTC). Since that time, several further requirements have been added by other authors. The present article critically evaluates and modifies the original criteria and adds two more principles, validity and reliability, that we recognize as crucially important in the performance of PTC. The revised criteria should be taken into consideration in the planned technical redesign of the nationwide PTC. Diagn. Cytopathol. 2007;35:61–64. © 2006 Wiley‐Liss, Inc.
1‐Alkoxy‐2,5‐diphenylphospholane and ‐phospholanium Salts in Rhodium‐Catalyzed Asymmetric Hydrogenation
Authors: Galland Aurore , Paris Jean Marc , Schlama Thierry , Guillot Régis , Fiaud Jean‐Claude , Toffano Martial 
Published: December 2006

AbstractA series of chiral enantiopure phosphinites was synthesized in four steps starting from phosphinic acid. New species were obtained as alkoxyphosphonium compounds. They can be used in the asymmetric hydrogenation of functionalized alkenes. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Nuclear‐Spin Polarization in Electron‐Transfer Reactions of Amines
Authors: Roth Heinz D. 
Published: December 2006

AbstractChemically induced dynamic nuclear polarization (CIDNP) observed during electron transfer (ET) reactions of tertiary amines such as DABCO (1) or Et3N (2) with a wide range of electron acceptors support the involvement of amine radical‐cations (e.g., 1.+ or 2.+) as key intermediates. Radical ions such as 2.+ may be deprotonated, generating neutral aminoalkyl radicals (e.g., 2.). When generated by reaction with an electron acceptor of energetically low triplet state such as naphthalene (1Naph*), the resulting pair 2.+/Naph.− reacts mostly by reverse electron transfer (RET) from triplet pairs populating the naphthalene triplet state.
Thioglucosides from the Seeds of Raphanus sativus L.
Authors: Duan Li‐Xin , Feng Bao‐Min , Wang Wei , Chen Fang , Cai Guang‐Ming , Pei Yue‐Hu , Wang Yong‐Qi 
Published: December 2006

AbstractThree new thioglucosides, (4E)‐5‐{6‐O‐[(2E)‐3‐(4‐hydroxy‐3‐methoxyphenyl)prop‐2‐enoyl]‐β‐glucopyranosylsulfanyl}pent‐4‐enenitrile (1), (4E)‐5‐{6‐O‐[(2E)‐3‐(4‐hydroxy‐3,5‐dimethoxyphenyl)prop‐2‐enoyl]‐β‐glucopyranosylsulfanyl}pent‐4‐enenitrile (2) and its (4Z)‐isomer 3, were isolated from the seeds of Raphanus sativus L. (radish), together with two known compounds. Their structures were determined by spectroscopic methods, including UV/VIS, 1D‐ and 2D‐NMR, FAB‐ and HR‐FAB‐MS experiments.
Targeting of Single‐Stranded Oligonucleotides through Metal‐Induced Cyclization of Short Complementary Strands
Authors: Freville Fabrice , Richard Tristan , Bathany Katell , Moreau Serge 
Published: December 2006

AbstractA new strategy to cyclize short synthetic oligonucleotides on DNA or RNA target strands is described. The approach is based on metal‐templated cyclization of short synthetic oligonucleotides conjugated with two chelating 2,2′ : 6′,2′′‐terpyridine (Tpy) moieties at their 3′‐ and 5′‐ends. Cyclization after metal addition (Zn2+, Fe2+) was demonstrated by means of thermal‐denaturation experiments, MALDI‐Q‐TOF‐MS, and gel electrophoresis (PAGE). 1D‐ and 2D‐NMR Experiments were performed to analyze the association of complementary strands after metal‐mediated cyclization. Our protocol allows the efficient circularization of synthetic oligonucleotides. Thereby, the hybridization on a complementary strand was more efficient with an RNA target strand and a 2′‐O‐methylated circularized oligomer.
C19 and C20 Diterpene Alkaloids from Aconitum toxicumRchb.
Authors: Csupor Dezső , Forgo Peter , Csedő Károly , Hohmann Judit 
Published: December 2006

AbstractAcotoxinine (1), a new norditerpene alkaloid, was isolated from the roots of Aconitum toxicum Rchb., together with the structurally related C19 diterpene alkaloids neoline (2) and aconitine (3) and C20 diterpene alkaloids songorine (4) and songoramine (5). The structures were elucidated by HR‐MS and advanced NMR methods, including 1H‐NMR, JMOD, 1H,1H‐COSY, HSQC, and HMBC experiments. This is the first report of C20 diterpenoid alkaloids in Aconitum toxicum.