bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial complex I density is associated with IQ and cognition in cognitively healthy adults: an in vivo [18F]BCPP-EF PET study
Authors: Shatalina Ekaterina , Whitehurst Thomas S. , Onwordi Ellis Chika , Gilbert Barnabas J. , Rizzo Gaia , Whittington Alex , Mansur Ayla , Tsukada Hideo , Marques Tiago Reis , Natesan Sridhar , Rabiner Eugenii A. , Wall Matthew B. , Howes Oliver D. 
Published: April 2024

Abstract
Background
Mitochondrial function plays a key role in regulating neurotransmission and may contribute to general intelligence. Mitochondrial complex I (MC-I) is the largest enzyme of the respiratory chain. Recently, it has become possible to measure MC-I distribution in vivo, using a novel positron emission tomography tracer [18F]BCPP-EF, thus, we set out to investigate the association between MC-I distribution and measures of cognitive function in the living healthy brain.

Results
Analyses were performed in a voxel-wise manner and identified significant associations between [18F]BCPP-EF DVRCS−1 in the precentral gyrus and parietal lobes and WAIS-IV predicted IQ, WAIS-IV arithmetic and WAIS-IV symbol-digit substitution scores (voxel-wise Pearson’s correlation coefficients transformed to Z-scores, thresholded at Z = 2.3 family-wise cluster correction at p < 0.05, n = 16). Arithmetic scores were associated with middle frontal and post-central gyri tracer uptake, symbol-digit substitution scores were associated with precentral gyrus tracer uptake. RAVLT recognition scores were associated with [18F]BCPP-EF DVRCS−1 in the middle frontal gyrus, post-central gyrus, occipital and parietal regions (n = 20).

Conclusions
Taken together, our findings support the theory that mitochondrial function may contribute to general intelligence and indicate that interindividual differences in MC-I should be a key consideration for research into mitochondrial dysfunction in conditions with cognitive impairment.
Joint beamforming and power splitting design for MISO downlink communication with SWIPT: a comparison between cell-free massive MIMO and small-cell deployments
Authors: Liu Jain-Shing , Lin Chun-Hung Richard , Chang Wan-Ling 
Published: April 2024

AbstractSimultaneous wireless information and power transfer (SWIPT) has been advocated as a highly promising technology for enhancing the capabilities of 5G and 6G devices. However, the challenge of dealing with large propagation path loss poses a significant hurdle. To address this issue, massive multiple-input multiple-output (MIMO) is employed to enhance the efficiency of SWIPT in cellular-based networks with multiple small cells, and especially increase the energy for cell-edge users. In addition, by leveraging a large set of spatially distributed base stations to collaboratively serve SWIPT-enabled user equipment, the cell-free massive MIMO has the potential to provide even better performance than the conventional small-cell systems. In this work, we extend the investigation to include the application of SWIPT technology with alternating current (AC) logic in the cell-free networks and the small-cell networks and propose joint beamforming and power splitting optimization frameworks to maximize the system sum-rate, subject to the constraints on harvested energy, AC logic energy supply, and total transmit power. The optimization problem is shown to be non-convex, posing a significant challenge. To address this challenge, we resort to a two-stage decomposition approach. Specifically, we first introduce quadratic transform-based fractional programming (FP) algorithms to iteratively solve the non-convex optimization problems in the first stage, achieving near-optimal solutions with low time complexities. To further reduce the complexities, we also incorporate conventional schemes such as zero forcing, maximum ratio transmission, and signal-to-leakage-and-noise ratio for the design of beamforming vectors. Second, to determine the optimal power splitting ratio within the framework, we develop a one-dimensional (1-D) search algorithm to tackle the single variable optimization problem reduced in the second stage. These algorithms are then evaluated in the context of cell-free MIMO and small-cell networks with numerical experiments. The results show that the FP-based algorithms can consistently outperform those utilizing the conventional beamforming schemes, and the solutions of this work can achieve up to fivefold improvement in the system sum-rate than the small-cell counterpart while providing different but comparable performance trends in energy harvesting (EH).
Decline of a distinct coral reef holobiont community under ocean acidification
Authors: Williams Jake , Pettorelli Nathalie , Hartmann Aaron C. , Quinn Robert A. , Plaisance Laetitia , O’Mahoney Michael , Meyer Chris P. , Fabricius Katharina E. , Knowlton Nancy , Ransome Emma 
Published: April 2024

Abstract
Background
Microbes play vital roles across coral reefs both in the environment and inside and upon macrobes (holobionts), where they support critical functions such as nutrition and immune system modulation. These roles highlight the potential ecosystem-level importance of microbes, yet most knowledge of microbial functions on reefs is derived from a small set of holobionts such as corals and sponges. Declining seawater pH — an important global coral reef stressor — can cause ecosystem-level change on coral reefs, providing an opportunity to study the role of microbes at this scale. We use an in situ experimental approach to test the hypothesis that under such ocean acidification (OA), known shifts among macrobe trophic and functional groups may drive a general ecosystem-level response extending across macrobes and microbes, leading to reduced distinctness between the benthic holobiont community microbiome and the environmental microbiome.

Results
We test this hypothesis using genetic and chemical data from benthic coral reef community holobionts sampled across a pH gradient from CO2 seeps in Papua New Guinea. We find support for our hypothesis; under OA, the microbiome and metabolome of the benthic holobiont community become less compositionally distinct from the sediment microbiome and metabolome, suggesting that benthic macrobe communities are colonised by environmental microbes to a higher degree under OA conditions. We also find a simplification and homogenisation of the benthic photosynthetic community, and an increased abundance of fleshy macroalgae, consistent with previously observed reef microbialisation.

Conclusions
We demonstrate a novel structural shift in coral reefs involving macrobes and microbes: that the microbiome of the benthic holobiont community becomes less distinct from the sediment microbiome under OA. Our findings suggest that microbialisation and the disruption of macrobe trophic networks are interwoven general responses to environmental stress, pointing towards a universal, undesirable, and measurable form of ecosystem change.
Epidemiologic association and shared genetic architecture between cataract and hearing difficulties among middle-aged and older adults
Authors: Zhang Xiayin , Wang Shan , Liu Shunming , Du Zijing , Wu Guanrong , Liang Yingying , Huang Yu , Shang Xianwen , Hu Yijun , Zhu Zhuoting , Sun Wei , Zhang Xueli , Yu Honghua 
Published: April 2024

AbstractAge-related cataract and hearing difficulties are major sensory disorders that often co-exist in the global-wide elderly and have a tangible influence on the quality of life. However, the epidemiologic association between cataract and hearing difficulties remains unexplored, while little is known about whether the two share their genetic etiology. We first investigated the clinical association between cataract and hearing difficulties using the UK Biobank covering 502,543 individuals. Both unmatched analysis (adjusted for confounders) and a matched analysis (one control matched for each patient with cataract according to confounding factors) were undertaken and confirmed that cataract was associated with hearing difficulties (OR, 2.12; 95% CI, 1.98–2.27; OR, 2.03; 95% CI, 1.86–2.23, respectively). Furthermore, we explored and quantified the shared genetic architecture of these two complex sensory disorders at the common variant level using the bivariate causal mixture model (MiXeR) and conditional/conjunctional false discovery rate method based on the largest available genome-wide association studies of cataract (N = 585,243) and hearing difficulties (N = 323,978). Despite detecting only a negligible genetic correlation, we observe polygenic overlap between cataract and hearing difficulties and identify 6 shared loci with mixed directions of effects. Follow-up analysis of the shared loci implicates candidate genes QKI, STK17A, TYR, NSF, and TCF4 likely contribute to the pathophysiology of cataracts and hearing difficulties. In conclusion, this study demonstrates the presence of epidemiologic association between cataract and hearing difficulties and provides new insights into the shared genetic architecture of these two disorders at the common variant level.
MODELS: a six-step framework for developing an infectious disease model
Authors: Rui Jia , Li Kangguo , Wei Hongjie , Guo Xiaohao , Zhao Zeyu , Wang Yao , Song Wentao , Abudunaibi Buasiyamu , Chen Tianmu 
Published: April 2024

AbstractSince the COVID-19 pandemic began, a plethora of modeling studies related to COVID-19 have been released. While some models stand out due to their innovative approaches, others are flawed in their methodology. To assist novices, frontline healthcare workers, and public health policymakers in navigating the complex landscape of these models, we introduced a structured framework named MODELS. This framework is designed to detail the essential steps and considerations for creating a dependable epidemic model, offering direction to researchers engaged in epidemic modeling endeavors.
Graphical Abstract
Four-year follow-up of psychiatric and psychosomatic profile in patients with Inflammatory Bowel Disease (IBD)
Authors: Gostoli Sara , Ferrara Francesco , Quintavalle Ludovica , Tommasino Sara , Gigante Graziano , Montecchiarini Maria , Urgese Alessia , Guolo Francesco , Subach Regina , D’Oronzo Angelica , Polifemo Annamaria , Buonfiglioli Federica , Cennamo Vincenzo , Rafanelli Chiara 
Published: April 2024

AbstractPsychological characterization of patients affected by Inflammatory Bowel Disease (IBD) focuses on comorbidity with psychiatric disorders, somatization or alexithymia. Whereas IBD patients had higher risk of stable anxiety and depression for many years after the diagnosis of the disease, there is a lack of studies reporting a comprehensive psychosomatic assessment addressing factors of disease vulnerability, also in the long-term. The objective of this investigation is to fill this gap in the current literature. The aims were thus to assess: a) changes between baseline and a 4-year follow-up in psychiatric diagnoses (SCID), psychosomatic syndromes (DCPR), psychological well-being (PWB-I), lifestyle, gastrointestinal symptoms related to IBD and Irritable Bowel Syndrome (IBS)-like symptoms b) stability of psychiatric and psychosomatic syndromes at 4-year follow-up. A total of 111 IBD outpatients were enrolled; 59.5% of them participated at the follow-up. A comprehensive assessment, including both interviews and self-report questionnaires, was provided at baseline and follow-up. Results showed increased psychiatric diagnoses, physical activity, consumption of vegetables and IBS-like symptoms at follow-up. Additionally, whereas psychiatric diagnoses were no longer present and new psychopathological pictures ensued at follow-up, more than half of the sample maintained psychosomatic syndromes (particularly allostatic overload, type A behavior, demoralization) from baseline to follow-up. Long-term presence/persistence of such psychosocial burden indicates the need for integrating a comprehensive psychosomatic evaluation beyond traditional psychiatric nosography in IBD patients. Moreover, since psychosomatic syndromes represent vulnerability factors of diseases, further studies should target subgroups of patients presenting with persistent psychosomatic syndromes and worse course of the disease.
Tectonic exhumation of a metamorphic core in an arc-continent collision during oblique convergence, Taiwan
Authors: Byrne Timothy , Chojnacki Michael , Lewis Jonathan , Lee Jian-Cheng , Ho Gong-Ruei , Yeh En-Chao , Lee Yuan-Hsi , Tsai Chin-Ho , Evans Mark , Webb Laura 
Published: April 2024

AbstractObservations over the last few decades from a number of orogenic systems have highlighted the possible importance of tectonic exhumation, i.e., ductile thinning and normal faulting, in exhuming rocks once buried in high-pressure conditions. Taiwan is one of the few active orogens in the world where rocks that once experienced high-pressure metamorphism (> 50 km) are exposed at the Earth’s surface, providing a natural laboratory for advancing our understanding of exhumation processes. We integrate previously published studies of the Taiwan orogen with new structural, geochronological, and fluid inclusion microthermometry data to argue that tectonic extrusion and structural thinning played a critical role in exhuming the metamorphic core of the orogen until very recently, ca. 0.7 Ma. We propose a two-stage process for exhuming the high-pressure metamorphic rocks of the Yuli Belt: an initial stage where exhumation is driven primarily by pressure gradients in a subduction channel and a second stage that is initiated as an orogen-parallel regional-scale strike-slip zone, the Tailuko shear zone, is offset by an orogen-normal strike-slip zone. The offset generates an extensional bend that is filled with extruding high-pressure rocks as the upper crust is structurally thinned. Evidence for tectonic thinning comes primarily from a low-angle penetrative foliation that records significant vertical shortening and a suite of sub-vertical late-stage, mineral-filled veins. Isotopic dating indicates that the second stage started ca. 2.4–3.1 Ma and ended at ca. 0.7 Ma when the northern Backbone Range orocline started to form. We propose the low-angle foliation formed in the footwall of a regional-scale extensional shear zone that rooted to the east, beneath the forearc. Combined tectonic and erosional processes may have limited the topographic growth of the orogen from ~3.0 to < 1.0 Ma.
Aortoesophageal fistula due to esophageal cancer: a case report of successful management
Authors: Saisho Kohei , Mori Naoki , Nakagawa Masashi , Nakamura Eiji , Tanaka Yu , Kaku Hideaki , Tanaka Yuya , Isobe Taro , Otsuka Hiroyuki , Sudo Tomoya , Sakai Hisamune , Ishibashi Nobuya , Hisaka Toru , Tayama Eiki , Fujita Fumihiko 
Published: April 2024

Abstract
Background
Aortoesophageal fistula (AEF) is a rare but potentially life-threatening condition. The best treatment for the AEF due to esophageal carcinoma is still unresolved. Here, we report a rare case of AEF caused by esophageal cancer, that was successfully treated with emergency thoracic endovascular aortic repair (TEVAR), followed by esophagectomy and gastric tube reconstruction.

Case presentation
A 64-year-old man presented with loss of consciousness and hypotension during chemoradiotherapy for advanced esophageal cancer. Enhanced computed tomography showed extravasation from the descending aorta into the esophagus at the tumor site. We performed emergency TEVAR for the AEF, which stabilized the hemodynamics. We then performed thoracoscopic subtotal esophagectomy on day 4 after TEVAR to prevent graft infection, followed by gastric tube reconstruction on day 30 after TEVAR. At 9 months after the onset of AEF, the patient continues to receive outpatient chemotherapy and leads a normal daily life.

Conclusion
TEVAR is a useful hemostatic procedure for AEF. If the patient is in good condition and can continue treatment for esophageal cancer, esophagectomy and reconstruction after TEVAR should be performed to prevent graft infection and maintain quality of life.
How Much Energy Do E’Athletes Use during Gameplay? Quantifying Energy Expenditure and Heart Rate Variability Within E’Athletes
Authors: Nicholson Mitchell , Poulus Dylan , Robergs Rob , Kelly Vincent , McNulty Craig 
Published: April 2024

Abstract
Background
Research into esports suggests that e’athletes experience physiological stressors and demands during competition and training. The physiological demands of esports are poorly understood and need to be investigated further to inform future training guidelines, optimise performance outcomes, and manage e’athlete wellbeing. This research aimed to quantify the metabolic rate of esports gameplay and compare this outcome with heart rate variability within expert e’athletes.

Results
Thirteen healthy male participants ranked within the top 10% of their respective esports title participated in the study (age = 20.7 ± 2.69 years; BMI = 24.6 ± 5.89 kg·m− 2). Expired gas analysis indirect calorimetry measured gas exchange during rest and gaming. Compared to resting conditions, competitive esports gameplay significantly increased median energy expenditure (1.28 (IQR 1.16–1.49) kcal·min− 1 vs. 1.45 (IQR 1.20–1.77) kcal·min− 1, p = .02), oxygen consumption (0.27 (IQR 0.24–0.30) L·min− 1 vs. 0.29 (IQR 0.24–0.35) L·min− 1, p = .02) and carbon dioxide production (0.20 (IQR 0.19–0.27) L·min− 1vs. 0.27 (IQR 0.24–0.33) L·min− 1, p = .01). Competitive gameplay also resulted in a significant increase in heart rate (84.5 (IQR 74.1–96.1) bpm vs. 87.1 (IQR 80.3–104) bpm, p = .01) and decrease in R-R interval’s (710 (IQR 624–810) ms vs. 689 (IQR 579–747) ms, p = .02) when compared to rest. However, there were no significant differences in time or frequency measures of heart rate variability.

Conclusions
The data reveal increased physiological responses to metabolic rate, energy expenditure and cardiovascular function to esports game play within expert e’athletes. Further physiological research into the physical demands on e’athletes, the influence of different training programs to esport performance, and the added multivariate determinants to elite level esport performance are warranted.
Factors influencing Thai university students’ decisions to take COVID-19 vaccine booster doses: a cross-sectional survey
Authors: Thichumpa Weerakorn , Yimthin Naphat , Ratchatorn Anawat , Izumi Satoko , Pan-ngum Wirichada 
Published: April 2024

Abstract
Background
We aimed to describe the acceptance of COVID-19 vaccine booster doses and factors influencing this among Thai university students.

Methods
A cross-sectional survey was conducted between July and September 2022. All university students in Thailand were eligible to participate. We explored the acceptance rate of COVID-19 vaccine booster doses and regular vaccines (if available) among university students. Associations between factors influencing the acceptance of vaccination were analyzed by multiple logistic regression analysis.

Results
A total of 322 participants were surveyed (78.9% female, age 18 to 49 years (mean = 22.6, standard deviation = 5.47)). Most participants (85.7%) were undergraduate students (Bachelor level), and a proportion (84.8%) had a background in health sciences studies. The proportions who accepted booster doses and regular vaccines were 52.8% and 69.3%, respectively. Vaccine accessibility was found to be significantly associated with the acceptance of booster doses (adjusted odds ratio (AOR) = 2.77, 95% confidence interval (CI) = 1.10–6.97), while the availability of scientific evidence (AOR = 3.44, 95% CI = 1.21–9.77) was significantly associated with the acceptance of regular vaccines.

Conclusions
This study contributes to addressing the knowledge gap regarding acceptance of COVID-19 vaccine booster doses among university students in Thailand. Our findings revealed that vaccine accessibility and the availability of scientific evidence, as well as vaccination costs, influenced individuals’ decisions around accepting vaccine booster doses. Further research should focus on the dynamics of vaccine acceptance to facilitate the development of targeted strategies and support vaccination policymaking in Thailand.
Energy consumption data collection: case study on data center in a Thai University
Authors: Chatlatanagulchai Withit , Chantrapornchai Chantana 
Published: April 2024

Abstract
Objective
Energy usage in has been increased due to the rising demand of cloud infrastructure. The government policy has been focused on building the green IT data center. The energy data need to be collected in order to monitor the energy usage. However, in an old typical data center, the building has been built with no support of such data collection. In this research, we aim to design the energy data collection system for our existing data center, a case study of data center in Thailand at the university. Based on the collected data, an energy usage monitoring system and prediction can be developed.

Methods
In the case study of Kasetsart University data center, the building and electric layouts were predetermined. The building layout and existing IT hardware were investigated. We designed the meter types and the number of meters to be installed for the building the energy data collection system. The corresponding database system was also designed for data logging, data visualization and analysis purpose.

Results
As a result, 25 installed meters along with the add-on network system were installed for logging data. A data usage example was demonstrated by building the data visualization and analysis. The presented 1 year dataset collected showed the changes of energy usages which can be used to compare with real activities happening in the campus. This encourages the integration of other related environment data such as outside temperature which may affect the electric billing cost. The dataset can be used for prediction of the electric usage; thus, the policy for reducing the electric billing cost could be established. In this paper, as a data note, we focus on the methodology of data collection required for data center.