bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with the risk of progression and decompensation of heart failure in patients with an implantable cardioverter-defibrillator
Authors: Lebedeva N. B. , Talibullin I. V. , Parfenov P. G. , Egle A. P. , Barbarash O. L. 
Published: April 2024

Aim. To analyze clinical and anamnestic factors associated with the risk of acute decompensated heart failure (ADHF) in patients with an implanted cardioverter-defibrillator (ICD) with the development of a prognostic model based on the Kuzbass registry of patients with ICD.Material and methods. Prospective follow-up of 260 patients with reduced left ventricular ejection fraction (age 59 (53; 66) years, 214 (82,3%) men) from the Kuzbass registry of patients with ICD. Of them, 156 (60%) patients had ischemic cardiomyopathy, while the rest had non-ischemic cardiomyopathy. The mean follow-up period was 4,2±2,3 years after ICD implantation. The following basic information about patients were assessed: demographic data, social status, history of the underlying disease, concomitant diseases, vital signs, standard clinical and paraclinical parameters, drug therapy. During the follow-up period, all cases of ADHF and death were analyzed.Results. A total of 54 (20,8%) patients died, of which 48 (88,9%) died due to ADHF. During the follow-up period, 34 patients were hospitalized for ADHF, of which 13 (38,2%) died. Thirty-five (13,5%) patients died in the prehospital stage due to ADHF that developed against the background of the underlying disease (10 (27%) had dilated cardiomyopathy, 1 (2,8%) — rheumatic mitral valve disease, 24 (68,6%) — ischemic cardiomyopathy). Thus, a total of 69 cases of ADHF were registered, which accounted for 26,5% of the total group. Mortality in general group from ADHF was 18,5%. According to the Kaplan-Meier curve, most deaths occurred during the first 1,5 years of follow-up.The regression model for predicting the ADHF risk included left atrium size (p=0,05), male sex (p=0,001), NYHA class (p=0,0001), left ventricular ejection fraction <40% (p=0,0001), no intake of renin-angiotensin-aldosterone system inhibitors (p=0,007) and amiodarone (p=0,028). The area under the ROC curve (AUC), sensitivity and specificity of the created model was 0,8, 69,2% and 80%, respectively.Conclusion. A set of routine clinical and anamnestic factors has been identified that makes it possible to predict the risk of ADHF in patients with ICDs, which must be taken into account before making a decision to implant the device. Particular attention should be paid to mandatory therapy for heart failure, as the main modifiable risk factor for ADHF.
Gene polymorphism and serum levels of some angiogenic growth factors and pro- and anti-inflammatory cytokines in patients with post-infarction cardiac remodeling
Authors: Nikolaeva A. M. , Babushkina N. P. , Ryabova T. R. , Dolbnya A. D. , Kologrivova I. V. , Shavrak V. E. , Ryabova V. V. 
Published: April 2024

Aim. To investigate the polymorphic variants of IL10, FGF2, VEGFD, TRAIL, SELE, TNFA and TNFβ genes in patients with primary ST-segment elevation myocardial infarction (MI) (STEMI) and to evaluate their association with late post-infarction cardiac remodeling.Material and methods. The study includes 74 patients age 61±10,7 years with primary STEMI. Percutaneous coronary intervention with restoration of infarct-related artery patency was performed in all patients after 60 (40; 80) minutes since admission to the hospital. Serum levels of fibroblast growth factor (FGF), interleukin-10 (IL-10), tumor necrosis factor family cytokines (TNF-α, TNF-β and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)) were measured with the Multiplex Instrument FLEXMAP 3D system (Luminex Corporation) and the MILLIPLEX Human Cytokine/Chemokine Panel II on the 1st, 7th day of early post-MI period and after 6 and 12 months. The late adverse cardiac remodeling was determined after 12 months of long-term post-MI period according to 2D echo­cardiography. The increase in left ventricular end-diastolic volume by 15% or more by 12 months was considered late adverse cardiac remodeling. The patients were genotyped by 16 single-nucleotide polymorphisms (SNPs) in the TNFβ, TNF, Il10, TNFRSF1B, VEGFD, TRAIL, FGF2, SELE genes.Results. Adverse cardiac remodeling occurred in 19 patients (25,7%). The genetic association analysis revealed the significant association of rs1800629 TNFA (χ2=4,748; p=0,029), rs5353 SELE (χ2=10,85; p=0,004) and rs6632528 VEGFD (χ2=8,127; p=0,017) with an increased risk of STEMI. Higher concentration of IL-10 was detected on the 7th day of MI (p=0,05) and 6 months later (p=0,028) in A/T rs3024492 genotype carriers, as well as FGF in T/T rs13122694 genotype carriers by the 6th month after the event (p=0,04). The dependence of the main LV indicators on the distribution of polymorphism genotypes rs3024492 IL10, rs13122694 FGF2 and rs4830939 VGEFD was discovered. In the first 24 hours of MI in rs3024492 IL10 heterozygotes, LV contractile function was worse in comparison with T/T genotype carriers. Also, carriers of the T/T rs13122694 FGF2 genotype were distinguished by higher LV ejection fraction, longitudinal global LV deformation and lower of LV end-systolic index in the early post-infarction period. In the long-term post-infarction period, T/T rs4830939 VEGFD carriers differed in a greater LV dilation than carriers of the C/C and C/T genotypes.Conclusion. The study showed the contribution of polymorphism of the inflammation system genes to a predisposition to STEMI — both at the levels of phenotype and individual signs.
Single-pill combination of indapamide and perindopril: potential of practical application
Authors: Kochergina A. M. , Kashtalap V. V. 
Published: April 2024

The effectiveness of blood pressure control can be increased with the use of single-pill combinations. When choosing an agent, the evidence of its components should be focused. The selection criteria are not only the direct effects of reducing blood pressure, but also organ protection and the impact on prognosis. Perindopril and indapamide have many years of experience in use in a wide range of patients and are used with the same effectiveness in the treatment of hypertension in young and elder­ly patients, in normal-weight and obese people, as tools for the primary prevention of myocardial infarction and stroke, and also as a way to prevent recurrent events.The article provides data on the advantages of perindopril and indapamide, the potential of its single-pill combination, the pleiotropic and organ protective properties of this drug. We systematized results of related studies and reflected the main conclusions. Attention is paid to the latest data on the long-term effect of indapamide therapy on the risk of cardiovascular events.
Método rápido para la evaluación del riesgo químico por inhalación y contacto asociado al manejo de residuos peligrosos (Respel)
Authors: Álvarez Betancur Jaime Alberto , Vera Acevedo Luz Dinora , Suárez Medina Óscar J. 
Published: April 2024

Introducción. La gestión ambiental de los residuos peligrosos busca disminuir la generación; prevenir la contaminación y los riesgos sobre la salud humana. Objetivo. Proponer un método rápido para evaluar riesgo químico por inhalación y contacto asociado a residuos peligrosos, a partir de sus características de peligrosidad y el análisis de las etapas del ciclo de vida. Materiales y Métodos. Estudio de caso en una institución de educación superior. Se analizaron los procedimientos y condiciones de manejo de los residuos; se elaboró una metodología para la priorización de residuos según los peligros químicos; se identificaron los impactos potenciales del sistema-residuo mediante análisis de ciclo de vida puerta a puerta, a partir de información secundaria; se hizo una revisión bibliográfica de las metodologías para la evaluación del riesgo químico. Resultados y discusión. Método de aplicación rápida para la evaluación del riesgo químico sobre la salud por inhalación y contacto enfocado en los peligros y en las etapas del ciclo de vida de los residuos peligrosos. Incluye la percepción de las personas involucradas en el proceso. Contempla dos niveles de evaluación, el primero ofrece un diagnóstico inicial de la situación del riesgo. La aplicación del segundo nivel procede de acuerdo al resultado del primero. Conclusiones. Los métodos convencionales que abordan el riesgo químico se enfocan básicamente en las sustancias químicas y no en los residuos. El análisis del ciclo de vida posibilita identificar los aspectos ambientales críticos en cada etapa de la gestión de los residuos peligrosos, esto permite prevenir impactos negativos y riesgos sobre la salud y el ambiente. La metodología hace énfasis en los riesgos asociados a los residuos peligrosos, permitiendo una evaluación rápida que lleva a un diagnóstico inicial de la situación; responde a la exigencia de la normatividad colombiana, particularmente, el decreto 4741 de 2005 sobre evaluación de riesgos.
El páramo de Santurbán: reinvención de un territorio a partir de la reapropiación de lo común
Authors: Acevedo Tarazona Álvaro , Correa Lugos Andrés , Mejía Jerez Andrea 
Published: April 2024

Introducción: Desde el año 2010 el páramo de Santurbán es motivo de conflictos entre distintos sectores de la sociedad. El proyecto de megaminería encabezado por la empresa multinacional Greystar Resources Ltd, acarrea tensiones entre la población urbana y rural frente a las decisiones del Estado colombiano. El resultado de dichas tensiones son movilizaciones sociales que involucran distintos colectivos, la sociedad civil y los lugareños que problematizan sobre el territorio y el uso de los bienes comunes. Objetivo: El objetivo de este artículo es presentar los resultados investigativos frente a la construcción de representaciones del territorio como centro de preocupaciones comunes modeladas a partir de perspectivas e intereses distintos de habitantes de la antigua provincia de Soto, en el departamento de Santander y la población del área urbana en Bucaramanga. Método: Para rastrear la trazabilidad de dichas representaciones se recurre a la revisión documental de prensa y a la realización de entrevistas semiestructuradas a habitantes de los municipios de Vetas y California, así como a defensores ambientales del Área Metropolitana de Bucaramanga; también al análisis de la posición estatal. Resultado: Se evidencia un cambio en la relación de las personas con lo común en medio de la globalización y las políticas estatales. Son evidentes la necesidad del agua para los habitantes del Área Metropolitana de Bucaramanga, de la minería para los pobladores de los municipios cercanos al páramo de Santurbán y de la explotación aurífera a gran escala por parte del Estado colombiano y multinacionales. Conclusión: Si bien el proyecto de megaminería a cielo abierto en el páramo de Santurbán fue retirado, aún está en debate el uso de las riquezas auríferas que interesan a empresas mineras y lugareños. Frente a esta coyuntura las expresiones de protesta de los años 2010 y 2011 permiten construir significad
Site-Specific Ground-Motion Waveform Generation Using a Conditional Generative Adversarial Network and Generalized Inversion Technique
Authors: Yamaguchi Junki , Tomozawa Yusuke , Saka Toshihide 
Published: April 2024

ABSTRACT
Accurate ground-motion simulations are essential for seismic hazard assessments and engineering practices. Herein, we propose a novel method combining conditional generative adversarial networks (cGANs) and the generalized inversion technique (GIT) to generate site-specific and variability-controlled strong-motion seismograms. The cGANs calculate synthetic seismogram without amplitude scales. The GIT is to separate the source, path, and site characteristics from the Fourier amplitude spectrum (FAS) of the observed seismograms. This method is applied to plate boundary earthquakes off the Pacific coast of Tohoku, Japan. It successfully generates a set of strong-motion seismograms at a given magnitude, distance, and observation station. The output waveforms reproduce the P and S waves as well as coda waves. We validate the method through a quantitative comparison with observed seismograms in terms of both time-domain duration and frequency-domain amplitude characteristics, using metrics of peak ground acceleration (PGA), peak ground velocity, FASs, response spectra, and waveform duration time. The validation results show that the variation in the PGA of the observed seismograms and the synthetic seismograms has a standard deviation of 0.643, and the duration of the seismograms has a standard deviation of 0.346, comparable to the standard deviations seen in the previous studies. Our approach offers high accuracy in stochastic finite-source modeling for a period of 1 s or shorter. The two features of the method, site-specificity and variability control, can contribute to further improvements in seismic hazard assessment by incorporating empirical information based on observed seismograms.
PREDICTION OF THE TEMPERATURE REGIME OF AN UNDERGROUND COLLECTOR IN A GEOTHERMAL CIRCULATION-BASED HEATING SYSTEM
Authors: Redko Andriy , Redko Oleksandr , Kahramanyan Artur , Batyuta Maksym , Krasnopolsky Denis 
Published: April 2024

The results of a numerical study of the temperature regime of a geothermal field formation are presented. A mathematical model of the heat exchange process between geothermal fluid and rock has been developed. The model of geothermal fluid movement consists of a system of continuity, momentum, and energy equations. At the beginning of computer modeling, the geometry, system parameters, as well as initial and boundary conditions are defined. Water injection technology maintains reservoir pressure and high flow rates, but leads to a decrease in temperature in the aquifer. Reducing the temperature of the geothermal fluid is a crucial issue for long-term operation, the prediction of which is possible with the help of computer modeling. The cooling of the formation is determined by the position of the cooling front, which is defined by an isotherm with a temperature of 288 K. The solution has been obtained by computer modeling. It has been shown that the displacement of the formation cooling front is determined by the thermophysical properties of the rock formations, filtration rate, physical properties of the geothermal fluid, and the temperature of the geothermal fluid supplied to the injection well. The relationship governing the displacement of the formation cooling front has been obtained. The cooling of the formation depends on the distance between the production and injection wells of geothermal fluid and the pressure drop in the formation. The significant influence of the flow rate of the wells has been shown. With a flow rate of 10 m3 /h over an operating period of 7500 hours, the temperature of the geothermal fluid is predicted to decrease from 347 K to 338 K; with an increase in flow rate to 100 m3 /h, a decrease in temperature from 347 K to 325 K is possible. It has been shown that the cooling of the formation mainly occurs in the horizontal plane. Comparison of obtained numerical data with known literature has been performed. Extending the operational lifespan is possible through the implementation of the periodic short-term operation-stop technology (a 10-year cycle, totaling 100 years). This technology allows for greater heat extraction compared to longer-term operation (a 50-year cycle, totaling 100 years).Additionally, increasing the distance between production and injection wells to 1000-1500 meters reduces cooling rates and prolongs the lifespan of the geothermal system. When forecasting the temperature regime of geothermal reservoirs, it is necessary to monitor and refine mathematical models with operational and well research data.
EXPERIMENTAL STUDIES OF THE INFLUENCE OF ELECTRICAL POTENTIALS ON CORROSION PROCESSES IN REINFORCED CONCRETE SLEEVES
Authors: Plugin Andrii , Murygin Maksim , Krykun Oksana , Nadzhafov Elshad , Zinchenko Vladyslava 
Published: April 2024

Experimental studies of the influence of electric potentials on the intensity of corrosion processes in reinforced concrete structures of under-rail foundations have been conducted.A research methodology has been developed that involves the creation of these influences on models and the assessment of their consequences. The effects of capillary rise, evaporation, diffusion, crystallization of salts, electric potential have been created, and the impact of electric potential on the acceleration of transfer processes and manifestations of corrosion signs has been estimated.Models and experimental installations were made, research was conducted. The exposure of the models was carried out in an aqueous environment and in a sodium chloride solution without electrical influence (as a control) and under the influence of a pulsating unidirectional electric potential of the PUEP. It was established that the current through the models decreases under the influence of PUEP, and the specific electrical resistance of the models increases. PUEP accelerates the penetration of ions into the model by 4.43 times, and also causes stronger manifestations of signs of electrocorrosion of the armature. As a result of the exposure of the models without electrical influence in the water environment, weak corrosion of the armature outlets was noted, no corrosion of the armature was observed inside the model; in the sodium chloride solution, strong corrosion of the armature outlets and weak corrosion inside the model was observed. As a result of the influence of PUEP in the water environment, weak corrosion of the fittings was observed, inside the model, no corrosion of the fittings was observed; in the sodium chloride solution, weak corrosion of the armature outlets and strong corrosion was observed inside the model. It has been confirmed that the influence of PUEP significantly accelerates the transfer of ions in concrete and intensifies the corrosion processes of reinforcement. Acceleration of ion transport should also accelerate corrosion processes in concrete, but it is advisable to conduct their research with longer exposure periods of models and with the use of physicochemical methods. Means of draining the currents flowing from the rails through the sleepers were recommended and it was suggested to eliminate the armature discharges from their ends.
PENGARUH FAKTOR PENDORONG RANTAI PASOK TERHADAP INISIATIF GREEN SUPPLY CHAIN DAN EFEKNYA TERHADAP KINERJA LINGKUNGAN DAN BISNIS
Authors: Hasudungan James , Yunus Erlinda N. 
Published: April 2024

Currently, stakeholders continuously encourage companies to implement green supply chain management (GSCM) to reduce negative impact to environment. In this research, there are 4 drivers of green supply chain(GSC), consist of regulatory measures, customer pressures, competitor pressures, and socio-cultural responsibility. These GSC drivers was then used as variables to determine their impact on GSCM practice in Indonesian manufacturing companies. Despite the influence of GSC drivers on GSCM implementation, this research also seeks for the impact of GSCM implementation to company environmental and business performance. The sampling method utilized was purposive sampling method. This research used online questionnaire to collect the data and SmartPLS 4.0 as a tool to process data. This result reveals that regulatory measures, customer pressures, and socio-cultural responsibility give positif influence for GSCM implementation. However, this research found that competitor pressures have no impact to GSCM implementation in Indonesian manufacturing companies. GSCM implementation have positif impact for company environmental and business performance.
Acute Exercise for the Hypertensive Elderly Affects the Whole-Body Capillary: A Single- Center Pilot Trial
Authors: Miura MISA , Kohzuki Masahiro , Saito Chie , Sakai Satoshi , Sugaya Hisashi , Koyama Shingo , Matsui Yasushi , Sakuma Tohru , Ito Osamu , Yamagata Kunihiro 
Published: April 2024

Objective
To investigate nailfold capillary parameters in community-dwelling individuals aged over 60 years who have hypertension and do not exercise regularly. Furthermore, the study examined the correlations between capillary function and other health-related indicators.
Design
A single- center pilot trial
Setting
Faculty of Health, Tsukuba University of Technology, Japan
Participants
hypertensive community-dwelling elderly people
Intervention
Microcirculation was observed before and 1 min after arm-curl exercise by means microscopy of capillary with non-exercised limb. Additionally, we examined other health-related indicators.
Outcome measures: Acute effects of reperfusion on nailfold density, flow, and diameters. Secondary outcomes included the correlations between microvascular parameters and other health-related indicators. We hypothesized that brief exercise could enhance microcirculation reperfusion and correlate with other health-related parameters.
Results:
There were 20 participants with a mean (SD) age of 67.1 (5.8) years. The capillary flow rate changed from 2.3±6.7 to 2.7±0.2 log µm/s (P
PRESERVATIONAL ANALYSIS OF JURASSIC CLAM SHRIMPS FROM LA MATILDE FORMATION (PATAGONIA, ARGENTINA) BY LIBS AND RAMAN SPECTROSCOPIES
Authors: JIMÉNEZ VICTORIA CECILIA , MONFERRAN MATEO DANIEL , DÍAZ PACE DIEGO MARTIN , COPELLO GUILLERMO JAVIER , PELLERANO ROBERTO GERARDO , CABALERI NORA GRACIELA , GALLEGO OSCAR FLORENCIO 
Published: April 2024

Abstract
Preservation of arthropod cuticles is of paramount importance for taphonomic interpretations in which the fossil record of the chitin-protein complex is considered a key molecular signature of the group studied. In this work, different specimens of clam shrimps and their surrounding sedimentary matrix recovered from four localities of the La Matilde Formation (Patagonia, Argentina) were chemically analyzed for the first time by Laser-induced breakdown spectroscopy (LIBS) and RAMAN spectroscopic techniques. The spectral data recorded from the fossils were processed and analyzed through multivariate statistics, including Principal Component Analysis (PCA), Nonmetric Multidimensional Scaling (NMDS), and Analysis of Similarities (ANOSIM). The correlation between the different colorations featured by the specimens and the atomic chemical composition of their carapaces was systematically investigated to gain a better understanding of the fossilization processes together with more detailed interpretations. We found that the carapaces featuring a yellow-brown color exhibited a similar chemical profile with iron predominance, while those with the same color as the sedimentary matrix presented a distinctive composition. Considering the volcanic influence to which the different localities studied and carapaces were exposed, we propose that the clam shrimps from the four localities were preserved in at least three ways, namely, (1) pyritization; (2) admixed preservation; and (3) impression, each with distinctive characteristics of the taphonomic processes involved. Overall, results obtained provide useful information to achieve a more comprehensive knowledge about the taphonomy of fossils in a Jurassic lacustrine paleo-environment, as the La Matilde Formation.