bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the differential expression of serum miR-21-5p, miR-135-5p, and miR-155-5p by Bifidobacterium triplex viable capsules during the perioperative stage of colorectal cancer
Authors: Zhang Jing , Guo Ji , He Ruochong , Li Ji , Du Bingyi , Zhang Yi , He Rongliang , Cheng Haixia 
Published: April 2024

Abstract

Objective
In this study, we investigated the impact of perioperative administration of Bifidobacterium triplex viable capsules on the serum levels of circulating miR-21-5p, miR-135-5p, and miR-155-5p in patients with colorectal cancer (CRC). The purpose of this study is to provide a foundation for future research on the use of Bifidobacterium triplex viable capsules to enhance postoperative recovery in patients with CRC.

Methods
A total of 60 patients with primary CRC admitted to the Department of General Surgery at Shanxi Bethune Hospital between June 2020 and December 2020 were selected and randomly divided into two groups: 20 cases in the control group and 40 cases in the experimental group. The experimental group was administered oral Bifidobacterium triplex viable capsules during the perioperative period, while the control group was administered oral placebo. Before and after the perioperative period, the expression levels of miR-21-5p, miR-135-5p, and miR-155-5p were compared in the serum of both groups of patients. Furthermore, we established the prognostic value of these three miRNAs in CRC patients.

Results
After surgery, the expression levels of miR-21-5p, miR-135-5p, and miR-155-5p decreased in both groups of patients (P < 0.05). Significantly greater differences were observed between miR-21-5p and miR-135-5p (P < 0.001). Expression levels of serum miR-21-5p (P = 0.020) and miR-135-5p (P = 0.023) decreased significantly more in the experimental group than in the control group. The levels of the above three miRNAs after surgery did not correlate with 3-year OS (HR = 4.21; 95% CI 0.37–47.48; log-rank P = 0.20) or 3-year DFS (HR = 1.57; 95% CI 0.32–7.66; log-rank P = 0.55) in two groups.

Conclusion
Radical surgery reduces the levels of serum miR-21-5p, miR-135-5p, and miR-155-5p expression in patients with CRC. The use of Bifidobacterium triplex viable capsules assists in achieving quicker perioperative recovery from radical surgery in CRC patients, and this underlying mechanism may be associated with the regulation of serum miR-21-5p, miR-135-5p, and miR-155-5p expression levels.
Glycemic response to meals with a high glycemic index differs between morning and evening: a randomized cross-over controlled trial among students with early or late chronotype
Authors: Stutz Bianca , Krueger Bettina , Goletzke Janina , Jankovic Nicole , Alexy Ute , Herder Christian , Dierkes Jutta , Berg-Beckhoff Gabriele , Jakobsmeyer Rasmus , Reinsberger Claus , Buyken Anette E. 
Published: April 2024

Abstract
Purpose
Glycemic response to the same meal depends on daytime and alignment of consumption with the inner clock, which has not been examined by individual chronotype yet. This study examined whether the 2-h postprandial and 24-h glycemic response to a meal with high glycemic index (GI) differ when consumed early or late in the day among students with early or late chronotype.

Methods
From a screening of 327 students aged 18–25 years, those with early (n = 22) or late (n = 23) chronotype participated in a 7-day randomized controlled cross-over intervention study. After a 3-day observational phase, standardized meals were provided on run-in/washout (days 4 and 6) and intervention (days 5 and 7), on which participants received a high GI meal (GI = 72) in the morning (7 a.m.) or in the evening (8 p.m.). All other meals had a medium GI. Continuous glucose monitoring was used to measure 2-h postprandial and 24-h glycemic responses and their variability.

Results
Among students with early chronotype 2-h postprandial glucose responses to the high GI meal were higher in the evening than in the morning (iAUC: 234 (± 92) vs. 195 (± 91) (mmol/L) × min, p = 0.042). Likewise, mean and lowest 2-h postprandial glucose values were higher when the high GI meal was consumed in the evening (p < 0.001; p = 0.017). 24-h glycemic responses were similar irrespective of meal time. Participants with late chronotype consuming a high GI meal in the morning or evening showed similar 2-h postprandial (iAUC: 211 (± 110) vs. 207 (± 95) (mmol/L) × min, p = 0.9) and 24-h glycemic responses at both daytimes.

Conclusions
Diurnal differences in response to a high GI meal are confined to those young adults with early chronotype, whilst those with a late chronotype seem vulnerable to both very early and late high GI meals. Registered at clinicaltrials.gov (NCT04298645; 22/01/2020).
Accuracy of routinely collected hospital administrative discharge data and death certificate ICD-10 diagnostic coding in progressive supranuclear palsy and corticobasal syndrome: a systematic review and validation study
Authors: Swallow Diane M. A. , Counsell Carl E. 
Published: April 2024

Abstract
Background
We conducted a systematic review to identify existing ICD-10 coding validation studies in progressive supranuclear palsy and corticobasal syndrome [PSP/CBS]) and, in a new study, evaluated the accuracy of ICD-10 diagnostic codes for PSP/CBS in Scottish hospital inpatient and death certificate data.

Methods
Original studies that assessed the accuracy of specific ICD-10 diagnostic codes in PSP/CBS were sought. Separately, we estimated the positive predictive value (PPV) of specific codes for PSP/CBS in inpatient hospital data (SMR01, SMR04) compared to clinical diagnosis in four regions. Sensitivity was assessed in one region due to a concurrent prevalence study. For PSP, the consistency of the G23.1 code in inpatient and death certificate coding was evaluated across Scotland.

Results
No previous ICD-10 validation studies were identified. 14,767 records (SMR01) and 1497 records (SMR04) were assigned the candidate ICD-10 diagnostic codes between February 2011 and July 2019. The best PPV was achieved with G23.1 (1.00, 95% CI 0.93–1.00) in PSP and G23.9 in CBS (0.20, 95% CI 0.04–0.62). The sensitivity of G23.1 for PSP was 0.52 (95% CI 0.33–0.70) and G31.8 for CBS was 0.17 (95% CI 0.05–0.45). Only 38.1% of deceased G23.1 hospital-coded cases also had this coding on their death certificate: the majority (49.0%) erroneously assigned the G12.2 code.

Discussion
The high G23.1 PPV in inpatient data shows it is a useful tool for PSP case ascertainment, but death certificate coding is inaccurate. The PPV and sensitivity of existing ICD-10 codes for CBS are poor due to a lack of a specific code.
Survival outcome following surgical versus non-surgical treatment of colorectal lung metastasis—a retrospective cohort study
Authors: Denz Axel , Hahn Veronika , Weber Klaus , Weber Georg F. , Grützmann Robert , Krautz Christian , Brunner Maximilian 
Published: April 2024

Abstract
Purpose
The optimal management of colorectal lung metastases (CRLM) is still controversial. The aim of this study was to compare surgical and non-surgical treatment for CRLM regarding the prognostic outcome.

Methods
This retrospective single-center cohort study included 418 patients, who were treated from January 2000 to December 2018 at a German University Hospital due to their colorectal carcinoma and had synchronous or metachronous lung metastases. Patients were stratified according the treatment of the CRLM into two groups: surgical resection of CRLM versus no surgical resection of CRLM. The survival from the time of diagnosis of lung metastasis was compared between the groups.

Results
Two- and 5-year overall survival (OS) from the time of diagnosis of lung metastasis was 78.2% and 54.6%, respectively, in our cohort. Patients undergoing pulmonary metastasectomy showed a significantly better 2- and 5-year survival compared to patients with non-surgical treatment (2-year OS: 98.1% vs. 67.9%; 5-year OS: 81.2% vs. 28.8%; p < 0.001). Multivariate Cox regression revealed the surgical treatment (HR 4.51 (95% CI = 2.33–8.75, p < 0.001) and the absence of other metastases (HR 1.79 (95% CI = 1.05–3.04), p = 0.032) as independent prognostic factors in patients with CRLM.

Conclusion
Our data suggest that patients with CRLM, who qualify for surgery, benefit from surgical treatment. Randomized controlled trials are needed to confirm our findings.

Clinical trial registry number
The work has been retrospectively registrated at the German Clinical Trial Registry (DRKS00032938).
Long non-coding RNA RAD51-AS1 promotes the tumorigenesis of ovarian cancer by elevating EIF5A2 expression
Authors: Zhao Lu , Huang Jia , Liu Wenting , Su Xiaoyan , Zhao Bei , Wang Xianggang , He Xiaoju 
Published: April 2024

Abstract
Purpose
The present study aims to determine the molecular mechanism mediated by RAD51 antisense RNA 1 (RAD51-AS1) in ovarian cancer (OvCA).

Methods
The data associated with RAD51-AS1 in OvCA were obtained from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database. Relative expression of RAD51-AS1 was detected. Determination of cell proliferation, metastasis, and invasion was performed by cell counting, colony formation, would-healing, and transwell invasion assays. Protein levels were detected by western blotting. The molecular mechanism mediated by RAD51-AS1 was predicted by bioinformatics analysis and verified by dual-luciferase reporter assays. Subcutaneous tumorigenesis models were used to confirm the function of RAD51-AS1 in vivo.

Results
Data from TCGA and GEO showed that RAD51-AS1 was associated with poor prognosis in OvCA patients and DNA repair, cell cycle, focal adhesion, and apoptosis in SKOV3.ip cells. High levels of RAD51-AS1 were detected in OvCA cells. Overexpressing RAD51-AS1 enhanced the proliferative, invading, and migratory capabilities of OvCA cells in vitro while silencing RAD51-AS1 exhibited the opposite effects. Mechanically, RAD51-AS1 elevated eukaryotic initiation factor 5A2 (EIF5A2) expression as a sponge for microRNA (miR)-140-3p. Finally, the role of RAD51-AS1 was verified by subcutaneous tumorigenesis models.

Conclusion
RAD51-AS1 promoted OvCA progression by the regulation of the miR-140-3p/EIF5A2 axis, which illustrated the potential therapeutic target for OvCA.
Targeted multifidus muscle activation reduces fibrosis of multifidus muscle following intervertebral disc injury
Authors: James G. , Ahern B. J. , Goodwin W. , Goss B. , Hodges P. W. 
Published: April 2024

Abstract
Purpose
Aerobic exercise produces beneficial outcomes in patients with low back pain and partially attenuates the fibrotic changes to the multifidus in a model of intervertebral disc (IVD) degeneration. More targeted exercise might be required to fully attenuate these fibrotic alterations. This study aimed to investigate whether activation of the multifidus induced by neurostimulation could reduce fibrosis of the multifidus in a model of IVD degeneration in sheep.

Methods
IVD degeneration was induced in 18 merino sheep via a partial thickness unilateral annulus fibrosus lesion to the L1/2 and L3/4 IVDs. All sheep received an implantable neurostimulation device that provides stimulation of the L2 medial branch of the dorsal ramus. Three months after surgery, the animals were assigned to Injury or Activated groups. Activated animals received neurostimulation and the Injury group received no stimulation. Six months after surgery, the multifidus was harvested at L2 and L4. Van Gieson’s, Sirius Red and immunofluorescence staining for Collagen-I and -III and quantitative PCR was used to examine fibrosis. Muscle harvested from a previous study without IVD injury was used as a control.

Results
Neurostimulation of the multifidus attenuated IVD degeneration dependent increases in the connective tissue, including Collagen-I but not Collagen-III, compared to the Injury group at L4. No measures of the multifidus muscle at L2, which received no stimulation, differed between the Injury and Activated groups.

Conclusions
These data reveal that targeted activation of the multifidus muscle attenuates IVD degeneration dependent fibrotic alterations to the multifidus.
A clinical assessment of three-dimensional-printed liver model navigation for thrice or more repeated hepatectomy based on a conversation analysis
Authors: Igami Tsuyoshi , Maehigashi Akihiro , Nakamura Yoshihiko , Hayashi Yuichiro , Oda Masahiro , Yokoyama Yukihiro , Mizuno Takashi , Yamaguchi Junpei , Onoe Shunsuke , Sunagawa Masaki , Watanabe Nobuyuki , Baba Taisuke , Kawakatsu Shoji , Mori Kensaku , Miwa Kazuhisa , Ebata Tomoki 
Published: April 2024

Abstract
Purposes
We performed a conversation analysis of the speech conducted among the surgical team during three-dimensional (3D)-printed liver model navigation for thrice or more repeated hepatectomy (TMRH).

Methods
Seventeen patients underwent 3D-printed liver navigation surgery for TMRH. After transcription of the utterances recorded during surgery, the transcribed utterances were coded by the utterer, utterance object, utterance content, sensor, and surgical process during conversation. We then analyzed the utterances and clarified the association between the surgical process and conversation through the intraoperative reference of the 3D-printed liver.

Results
In total, 130 conversations including 1648 segments were recorded. Utterance coding showed that the operator/assistant, 3D-printed liver/real liver, fact check (F)/plan check (Pc), visual check/tactile check, and confirmation of planned resection or preservation target (T)/confirmation of planned or ongoing resection line (L) accounted for 791/857, 885/763, 1148/500, 1208/440, and 1304/344 segments, respectively. The utterance’s proportions of assistants, F, F of T on 3D-printed liver, F of T on real liver, and Pc of L on 3D-printed liver were significantly higher during non-expert surgeries than during expert surgeries. Confirming the surgical process with both 3D-printed liver and real liver and performing planning using a 3D-printed liver facilitates the safe implementation of TMRH, regardless of the surgeon’s experience.

Conclusions
The present study, using a unique conversation analysis, provided the first evidence for the clinical value of 3D-printed liver for TMRH for anatomical guidance of non-expert surgeons.
Pharmacokinetics of L-theanine and the effect on amino acid composition in mice administered with L-theanine
Authors: Yamaura Shinnosuke , Sadamori Koki , Konishi Reiko , Majima Takashi , Mukai Akira , Uno Kyosuke , Kinjo Toshihiko , Komori Koji , Kuramoto Nobuyuki , Kawada Kou 
Published: April 2024

AbstractL-theanine, an amino acid component of the tea leaves of Camellia sinensis, is sold in Japan as a supplement for good sleep. Although several studies in humans and mice have reported the effects of L-theanine on brain function, only a few reports have comprehensively clarified the disposition of theanine administered to mice and its effects on concentrations of other blood amino acids. In this study, we aimed to determine the changes in the blood levels of L-theanine administered to mice and amino acid composition of the serum. L-theanine were administered to four-week-old Std-ddY male mice orally or via tail vein injection. L-theanine and other amino acids in serum prepared from blood collected at different time points post-dose were labeled with phenylisothiocyanate and quantified. The serum concentration of orally administered L-theanine peaked 15 min after administration. The area under the curve for tail vein injection revealed the bioavailability of L- theanine to be approximately 70%. L-theanine administration did not affect any amino acid levels in the serum, but a significant increase in the peak area overlapping the Glycine (Gly) peak was observed 30 min after administration. L-theanine administered to mice was rapidly absorbed and eliminated, suggesting that taking L-theanine as a supplement is safe without affecting its own levels or serum levels of other amino acids. However, considering that Gly, similar to L-theanine, is used as a dietary supplement for its anxiolytic effects and to improve sleep, determining the effects of L-theanine administration on Gly is important and needs further research.
Stochastic gradient descent without full data shuffle: with applications to in-database machine learning and deep learning systems
Authors: Xu Lijie , Qiu Shuang , Yuan Binhang , Jiang Jiawei , Renggli Cedric , Gan Shaoduo , Kara Kaan , Li Guoliang , Liu Ji , Wu Wentao , Ye Jieping , Zhang Ce 
Published: April 2024

AbstractModern machine learning (ML) systems commonly use stochastic gradient descent (SGD) to train ML models. However, SGD relies on random data order to converge, which usually requires a full data shuffle. For in-DB ML systems and deep learning systems with large datasets stored onblock-addressable secondary storagesuch as HDD and SSD, this full data shuffle leads to low I/O performance—the data shuffling time can be even longer than the training itself, due to massive random data accesses. To balance the convergence rate of SGD (which favors data randomness) and its I/O performance (which favors sequential access), previous work has proposed several data shuffling strategies. In this paper, we first perform an empirical study on existing data shuffling strategies, showing that these strategies suffer from either low performance or low convergence rate. To solve this problem, we propose a simple but noveltwo-leveldata shuffling strategy named , which canavoida full data shuffle while maintainingcomparableconvergence rate of SGD as if a full shuffle were performed. We further theoretically analyze the convergence behavior of and empirically evaluate its efficacy in both in-DB ML and deep learning systems. For in-DB ML systems, we integrate into PostgreSQL by introducing three newphysicaloperators with optimizations. For deep learning systems, we extend single-process to multi-process for the parallel/distributed environment and integrate it into PyTorch. Our evaluation shows that can achieve comparable convergence rate with the full-shuffle-based SGD for both linear models and deep learning models. For in-DB ML with linear models, is 1.6$$\times $$×$$-$$-12.8$$\times $$×faster than two state-of-the-art systems, Apache MADlib and Bismarck, on both HDD and SSD. For deep learning models on ImageNet, is 1.5$$\times $$×faster than PyTorch with full data shuffle.
Influence of nano-crystallization on Li-ion conductivity in glass Li$$_3$$PS$$_4$$: a molecular dynamics study
Authors: Kobayashi Ryo , Takemoto Seiji , Ito Ryuichiro 
Published: April 2024

AbstractUnderstanding the ionic conduction mechanisms in solid electrolyte glasses and glass-ceramics is an important task for improving the performance of next-generation all-solid-state batteries. Although many ionic conduction mechanisms have been proposed, the mechanism of increased ionic conductivity in partially crystallized glass is not fully understood. In this study, molecular dynamics was used to analyze the strain and local ion mobility in the glass around the crystal nano-particles of Li$$_3$$

3

PS$$_4$$

4

, which is a promising material for solid electrolytes. From the analysis of the results, we find that a local strain field is generated around the crystal particles and that the tensile strain field decreases the activation energy of ion migration and increases the ionic conductivity. This study opens the possibility of improving the ionic conductivity of glass-ceramics by controlling crystallization and dispersing the tensile strain field, even though the crystalline phase is not a high ionic conducting phase.
Adversarial attack detection framework based on optimized weighted conditional stepwise adversarial network
Authors: Barik Kousik , Misra Sanjay , Fernandez-Sanz Luis 
Published: April 2024

AbstractArtificial Intelligence (AI)-based IDS systems are susceptible to adversarial attacks and face challenges such as complex evaluation methods, elevated false positive rates, absence of effective validation, and time-intensive processes. This study proposes a WCSAN-PSO framework to detect adversarial attacks in IDS based on a weighted conditional stepwise adversarial network (WCSAN) with a particle swarm optimization (PSO) algorithm and SVC (support vector classifier) for classification. The Principal component analysis (PCA) and the least absolute shrinkage and selection operator (LASSO) are used for feature selection and extraction. The PSO algorithm optimizes the parameters of the generator and discriminator in WCSAN to improve the adversarial training of IDS. The study presented three distinct scenarios with quantitative evaluation, and the proposed framework is evaluated with adversarial training in balanced and imbalanced data. Compared with existing studies, the proposed framework accomplished an accuracy of 99.36% in normal and 98.55% in malicious traffic in adversarial attacks. This study presents a comprehensive overview for researchers interested in adversarial attacks and their significance in computer security.
Low-cost GNSS antennas in precise positioning: a focus on multipath and antenna phase center models
Authors: Krzan Grzegorz , Dawidowicz Karol , Paziewski Jacek 
Published: April 2024

AbstractThe rapid growth of the GNSS equipment market has put affordable receivers and antennas capable of receiving satellite signals into the hands of users. High positioning accuracy, previously achievable only with high-grade devices, is becoming possible with low-cost ones. However, simplifications in the design of these devices, intended to reduce the manufacturing cost, affect their capabilities. This study analyzes the positioning accuracy that may be achieved with recent low-cost antennas. We put particular stress on investigating the susceptibility of such antennas to the multipath effect and implications from the quality of the antenna phase center models. The positioning performance is assessed by employing the Precise Point Positioning method with the integer ambiguity resolution of phase observations. The results obtained with three low-cost antennas are validated against three high-grade antennas. We reveal a two-to threefold decrease in positioning performance with low-cost antennas compared to high-quality equipment. However, positioning accuracy increased when a low-cost antenna with a phase correction model was used, particularly for the eastern component of coordinate bias. In addition, a significant susceptibility of low-cost antennas to the multipath effect was confirmed, especially for GPS L2 and Galileo E5a signals.
Tailoring hydrophobicity vs. water capacity of adsorbents for adsorption applications: role of composites
Authors: Atalay-Oral Cigdem , Tatlier Melkon 
Published: April 2024

AbstractWater adsorption capacities of various adsorbents reported in the literature were investigated to define a hydrophobicity index that was plotted vs. water capacity. In this plot, logarithmic curves were proposed to be used as indicators of performance limits of adsorbents, especially for adsorption heat pumps. In spite of their useful adsorption properties, zeolites generally exhibited quite low hydrophobicity, remaining well below the logarithmic curve. In this study, the use of composites of zeolite NaY was examined both theoretically and experimentally for improvements in the water capacity and hydrophobicity. Salt impregnation and hydrothermal synthesis experiments were performed to prepare composites of zeolite NaY with LiCl/MgCl2 salts and activated carbon, respectively. Water capacity and hydrophobicity of zeolite NaY composites were generally superior to those of pure zeolite. Zeolite composites may be advantageous for enhancing adsorption capacity and hydrophobicity of zeolites while eliminating low stability and slow adsorption kinetics of other adsorbents. Interface between two different phases might indicate another opportunity to provide improved adsorption properties for zeolite composites.