bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ketone O‐(3,5,5‐Trimethyl‐4,5‐dihydro‐1H‐pyrazol‐1‐ylmethyl)oximes.
Authors: Kukharev B. F. , Stankevich V. K. , Sadykov E. Kh. , Lobanova N. A. , Kukhareva V. A. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 1‐Acyl‐1,2‐dihydro‐3H‐pyrazol‐3‐ones via Lewis Acid‐Mediated Rearrangement of 3‐Acyloxypyrazoles.
Authors: Maruoka Hiroshi , Yamagata Kenji , Okabe Fumi , Tomioka Yukihiko 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Design, Microwave‐Assisted Synthesis, and Spasmolytic Activity of 2‐(Alkyloxyaryl)‐1H‐benzimidazole Derivatives as Constrained Stilbene Bioisosteres.
Authors: Navarrete‐Vazquez Gabriel , Moreno‐Diaz Hermenegilda , Aguirre‐Crespo Francisco , Leon‐Rivera Ismael , Villalobos‐Molina Rafael , Munoz‐Muniz Omar , Estrada‐Soto Samuel 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 4,5‐Dihydroisoxazoles Connected by Short Spacers to the Pentafluoro‐λ6‐sulfanyl Group.
Authors: Brel Valry K. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Microwave Induced Synthesis of the Thiazolidine‐2,4‐dione Motif and the Efficient Solvent Free‐Solid Phase Parallel Syntheses of 5‐Benzylidene‐thiazolidine‐2,4‐dione and 5‐Benzylidene‐2‐thioxo‐thiazolidine‐4‐one Compounds.
Authors: Kumar B. R. Prashantha , Karvekar M. D. , Adhikary L. , Nanjan M. J. , Suresh B. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis, Structure and Biological Activities of [α‐(Alkylcarbonyl)‐2‐(1,2,4‐triazol‐1‐yl)] ethyl‐N,N‐dialkyldithiocarbamate Derivatives.
Authors: Jian Fangfang , Xiao Hailian , Zhu Chongyi , Xu Liangzhong 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and anti‐Angiogenesis Activity of Coumarin Derivatives.
Authors: Lee Seokjoon , Sivakumar Krishnamoorthy , Shin Woon‐Seob , Xie Fang , Wang Qian 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Unexpected Tandem Ylide Annulation Reaction for Controllable Synthesis of 2H‐Chromenes and 4H‐Chromenes.
Authors: Ye Long‐Wu , Sun Xiu‐Li , Zhu Chun‐Yin , Tang Yong 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Organocatalytic Tandem Michael—Aldol Reactions: One‐Pot Synthesis of Chiral Thiochromenes.
Authors: Wang Wei , Li Hao , Wang Jian , Zu Liansuo 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel Synthesis of 2,3‐Disubstituted‐4‐pyridones from 4‐Methoxypyridine.
Authors: Kitagawa Hideo , Kumura Ko , Atsumi Kunio 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Unusual Reaction of Ethyl 2‐Cyano‐3,3‐bis(methylsulfanyl)acrylate with Cyanothioacetamide.
Authors: Dyachenko V. D. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Series of Pyridinyl‐Alkynes as Antagonists of the Metabotropic Glutamate Receptor 5 (mGluR5)
Authors: Bach Peter , et al. et al. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Development of a One‐Pot Asymmetric Azaelectrocyclization Protocol: Synthesis of Chiral 2,4‐Disubstituted 1,2,5,6‐Tetrahydropyridines.
Authors: Kobayashi Toyoharu , Nakashima Miyuki , Hakogi Toshikazu , Tanaka Katsunori , Katsumura Shigeo 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
N‐Tetrahydroquinolinyl, N‐Quinolinyl and N‐Isoquinolinyl Biaryl Carboxamides as Antagonists of TRPV1.
Authors: Westaway Susan M. , et al. et al. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Catalytic Synthesis of New Halogen‐Containing Tetrahydroquinolin‐8‐ols.
Authors: Zhandarev V. V. , Goshin M. E. , Kazin V. N. , Ramenskaya L. M. , Mironov G. S. , Shishkina A. L. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
One‐Pot Synthesis of Hexahydroquinolines via a Four‐Component Cyclocondensation under Microwave Irradiation in Solvent Free Conditions: A Green Chemistry Strategy.
Authors: Tu Shujiang , Zhang Jinpeng , Zhu Xiaotong , Zhang Yan , Wang Qian , Xu Jianing , Jiang Bo , Jia Runhong , Zhang Junyong , Shi Feng 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
cis‐ and trans‐Decahydro‐1,6‐Naphthyridines. Stereoselective Synthesis and Stereochemistry.
Authors: Esipova T. V. , Borisenko A. A. , Grishina G. V. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Heterocyclizations of 5‐Methylpyrazol‐3‐amine with Unsaturated Arylaliphatic Carboxylic Acid Derivatives
Authors: Lipson V. V. , Desenko S. M. , Shirobokova M. G. , Shishkin O. V. , Shishkina S. V. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Transformation of 4‐Oxo‐4H‐[1]‐benzopyran‐3‐carboxaldehydes into Pyrazolo[3,4‐b]pyridines.
Authors: Stankovicova Henrieta , Gaplovsky Anton , Lacova Margita , Chovancova Jarmila , Puchala Agnieszka 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Isothiazolopyrimidines and Isoxazolopyrimidines as Novel Multi‐Targeted Inhibitors of Receptor Tyrosine Kinases.
Authors: Ji Zhiqin , et al. et al. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Design and Synthesis of Tetracyclic Nonpeptidic Biaryl Nitrile Inhibitors of Cathepsin K.
Authors: Setti Eduardo L. , Venkatraman Shankar , Palmer James T. , Xie Xiaoming , Cheung Harry , Yu Walter , Wesolowski Gregg , Robichaud Joel 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Novel 1‐Substituted [1,3]Thiazolo[3,2‐a][1,5]benzodiazepine Derivatives from 1,5‐Benzodiazepine‐2‐thiones and α‐Halogen Carbonyl Compounds.
Authors: Janciene Regina , Stumbreviciute Zita , Podeniene Daiva , Puodziunaite Benedikta D. , Black Steve , Husbands Stephen M. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sequential Double Claisen Rearrangement and Two‐Directional Ring‐Closing Metathesis as a Route to Various Benzofused Bisoxepin and Bisoxocin Derivatives.
Authors: Chattopadhyay Shital K. , Biswas Titas , Maity Susama 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
All‐Carbon‐Substituted Vinylsilane Stable to TBAF: Synthesis of Allyldimethylvinylsilane and Its Pd‐Catalyzed Cross‐Coupling under Mild Conditions.
Authors: Li Lianhai , Navasero Neenah 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Catalytic Synthesis of 1‐Arylethylphosphonates by the Hydrogenation of Unsaturated Precursors in the Presence of Chitosan‐Based Palladium Catalysts.
Authors: Finashina E. D. , Isaeva V. I. , Kustov L. M. , Gulyukina N. S. , Bondarenko G. N. , Beletskaya I. P. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Data on the Reaction of Selenium Tetrachloride with Acetylene.
Authors: Martynov A. V. , Ivanov A. V. , Amosova S. V. , Potapov V. A. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Uroleuconaphins A1 (I) and B1 (II), Two Red Pigments from the Aphid Uroleucon nigrotuberculatum (Olive)
Authors: Horikawa Mitsuyo , et al. et al. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydroarylation for the Facile Synthesis of 2‐Substituted Tetrahydroquinoline: A Concise Synthesis of (+)‐(S)‐Angustureine.
Authors: Ryu Jae‐Sang 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Lactones from a Brown Alga Endophytic Fungus (No. ZZF36) from the South China Sea and Their Antimicrobial Activities.
Authors: Yang Rui‐yun , Li Chun‐yuan , Lin Yong‐cheng , Peng Guang‐tian , She Zhi‐gang , Zhou Shi‐ning 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
10‐Methyl‐n‐heptacosane and Diglucosyldirhamnoside from the Stem Bark of Balanites aegyptiaca Delile.
Authors: Ansari M. M. , Ahmad J. , Ali M. , Ansari S. H. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Biological Evaluation of 1β‐Methylcarbapenems Having Cyclic Thiourea Moieties and Their Related Compounds.
Authors: Han T. , Cho J.‐H. , Oh C.‐H. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Transvalencin Z, a New Antimicrobial Compound with Salicylic Acid Residue from Nocardia transvalensis IFM 10065
Authors: Mukai Akira , Fukai Toshio , Matsumoto Yuko , Ishikawa Jun , Hoshino Yasutaka , Yazawa Katsukiyo , Harada Ken‐ichi , Mikami Yuzuru 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Diphenyl Ether from Marine‐Derived Fungus Aspergillus sp. B‐F‐2
Authors: Liu Rui , Zhu Weiming , Zhang Yapeng , Zhu Tianjiao , Liu Hongbing , Fang Yuchun , Gu Qianqun 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hit‐to‐Lead Optimization of 1,4‐Dihydroindeno[1,2‐c]pyrazoles as a Novel Class of KDR Kinase Inhibitors.
Authors: Dinges Juergen , et al. et al. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Polyhedral Boranes in the Nanoworld
Authors: Hawthorne M. Frederick , Farha Omar K. , Julius Richard , Ma Ling , Jalisatgi Satish S. , Li Tiejun , Bayer Michael J. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemical Modification of Nucleic Acids Toward Functional Nucleic Acid Systems
Authors: Venkatesan Natarajan , Seo Young Jun , Bang Eun Kyoung , Park Sun Min , Lee Yoon Suk , Kim Byeang Hyean 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Divinyl Sulfide and Its Selenium and Tellurium Analogues as Starting Materials for the Preparation of Polyfunctional Alkyl, Aromatic, and Heteroaromatic Vinyl Chalcogenides
Authors: Gavrilova Galina M. , Amosova Svetlana V. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Belt‐Shaped Unsaturated Cyclophanes: Synthesis and Properties of Benzannulenes Composed of cis‐Stilbene Units
Authors: Kuwatani Yoshiyuki 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Recent Applications of 2,4,6‐Trichloro‐1,3,5‐triazine and Its Derivatives in Organic Synthesis
Authors: Blotny Grzegorz 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Use of Iodocompounds in Radical Polymerization
Authors: David Ghislain , Boyer Cyrille , Tonnar Jeff , Ameduri Bruno , Lacroix‐Desmazes Patrick , Boutevin Bernard 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chiral Salen Complexes: An Overview to Recoverable and Reusable Homogeneous and Heterogeneous Catalysts
Authors: Baleizao Carlos , Garcia Hermenegildo 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Selective Chemical Bond Breaking Characteristically Induced by Resonant Core Excitation of Ester Compounds on a Surface
Authors: Wada Shin‐ichi , Kizaki Hiroyuki , Matsumoto Yoshihiro , Sumii Ryohei , Tanaka Kenichiro 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Small Molecule Oxidation Products Trigger Disease‐Associated Protein Misfolding
Authors: Bieschke Jan , Zhang Qinghai , Bosco Daryl A. , Lerner Richard A. , Powers Evan T. , Wentworth Paul Jr. , Kelly Jeffery W. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Design, Syntheses, Biological Evaluation, and Docking Studies of 2‐Substituted 5‐Methylsulfonyl‐1‐Phenyl‐1H‐Indoles: Potent and Selective in vitro Cyclooxygenase‐2 Inhibitors
Authors: Cruz‐López Olga , Díaz‐Mochón Juan José , Campos Joaquín M. , Entrena Antonio , Núñez María T. , Labeaga Luis , Orjales Aurelio , Gallo Miguel A. , Espinosa Antonio 
Published: November 2006

AbstractFour series of 5‐methylsulfonyl‐1‐phenyl‐1H‐indole‐2‐carboxylic acid alkyl esters (family A), ‐2‐carbonitriles (family B), ‐2‐carboxamides (family C), and 2‐benzoyl‐5‐methylsulfonyl‐1‐phenyl‐1H‐indoles (family D) were prepared and evaluated for their ability to inhibit purified cyclooxygenase‐2 (COX‐2) and cyclooxygenase‐1 (COX‐1). Family D compounds have the best COX‐1/COX‐2 inhibition ratios and potencies. According to docking studies, these molecules appear to bind the COX‐2 binding site differently than indomethacin, with the insertion of the substituent at the 2‐position in the hydrophobic pocket of the enzyme and the 1‐position phenyl ring in the trifluoromethyl zone. Among the group of compounds evaluated, 2‐(4‐chlorobenzoyl)‐1‐(4‐chlorophenyl)‐5‐methylsulfonyl‐1H‐indole and 2‐(4‐chlorophenyl)‐5‐methylsulfonyl‐1‐(4‐trifluoromethylphenyl)‐1H‐indole emerged as the most potent (respective IC50 values: 46 and 43 nM), and selective (respective selectivity indexes: >2163 and >2331) COX‐2 inhibitors.
Prognostic factors for survival after stereotactic radiosurgery vary with the number of cerebral metastases
Authors: DiLuna Michael L. , King Joseph T. , Knisely Jonathan P. S. , Chiang Veronica L. 
Published: November 2006

AbstractBACKGROUND.Little is understood about the factors that influence survival in patients who undergo gamma‐knife stereotactic radiosurgery (SRS) for brain metastases.METHODS.Demographic, disease, treatment, and survival data on 334 patients with intracranial metastases who underwent initial SRS from 1998 to 2004 were abstracted from treatment records and from the Connecticut Tumor Registry. Multivariate survival analysis was used to identify factors that independently affected survival.RESULTS.The median age of the patient population was 57.3 years. The median number of lesions treated in a single session was 2 (range, 1–36 lesions treated). The most common tumor histologies were nonsmall cell lung carcinoma (36%), breast cancer (16%), and melanoma (16%). Three hundred patients (90%) had confirmed deaths; the median survival after SRS was 8.1 months. Survival was significantly better in patients who had from 1 to 3 metastases (median, 8.5 months) compared with patients who had ≥4 metastases (median, 6.3 months; hazard ratio [HR], 0.65; P = .003). In the subgroup of patients who had from 1 to 3 metastases, systemic control (HR, 0.49; P < .001), breast cancer (HR, 0.57; P = .003), and total tumor volume < 5 cc (HR, 0.65; P = .002) were associated independently with increased survival, and esophageal cancer (HR, 2.36; P = .042) was associated with decreased survival. In the subgroup of patients who had ≥4 metastases, only age <45 years was associated independently with increased survival (HR, 0.39; P = .006); and melanoma (HR, 2.32; P = .008) and the receipt chemotherapy (HR, 2.59; P = .077) were associated with decreased survival. Sex, race, metastases location, whole‐brain radiation, and cranial surgery had no independent associations with altered survival.CONCLUSIONS.The data from this study suggested that different factors affected survival in patients who had from 1 to 3 metastases and patients who had ≥4 metastases. Further research into this area may clarify causes for this discrepancy and improve prognostication. Cancer 2007. © 2006 American Cancer Society.
Update of the decitabine experience in higher risk myelodysplastic syndrome and analysis of prognostic factors associated with outcome
Authors: Kantarjian Hagop M. , O'Brien Susan , Shan Jianqin , Aribi Ahmed , Garcia‐Manero Guillermo , Jabbour Elias , Ravandi Farhad , Cortes Jorge , Davisson Jan , Issa Jean‐Pierre 
Published: November 2006

AbstractBACKGROUND.Therapy for patients with myelodysplastic syndrome (MDS) with hypomethylating agents, like decitabine and 5‐azacitidine, has produced favorable results. In this study, the authors update their experience with decitabine in patients with MDS and analyze the cytogenetic response patterns and prognostic factors associated with decitabine therapy.METHODS.One hundred fifteen patients with higher risk MDS who received treatment with decitabine were reviewed. Patients received decitabine 100 mg/m2per course every 4 weeks in 3 different schedules: 1) 20 mg/m2intravenously daily × 5, 2) 20 mg/m2subcutaneously daily × 5, and 3) 10 mg/m2intravenously daily × 10. Decitabine was given for a median of ≥7 courses (range, 1–23 courses).RESULTS.Overall, 80 patients (70%) achieved a response according to the modified International Working Group criteria (IWG): complete response (CR), 40 patients (35%); partial response, 2 patients (2%); bone marrow CR with or without other hematologic improvements (HI), 26 patients (23%); and other HI, 12 patients (10%). Cytopenias were improved in 50% of patients. The median remission duration was 20 months, and the median survival was 22 months. Mortality was 3% at 6 weeks and 7% at 3 months. In a multivariate analysis, poor prognostic factors for achieving IWG CR were MDS (vs chronic myelomonocytic leukemia), longer duration of MDS, and prior MDS therapy. For survival, independent adverse prognostic factors were chromosome 5 and/or 7 abnormalities, older age, and prior MDS therapy (excluding growth factors).CONCLUSIONS.The longer term experience with decitabine in MDS was favorable. Pretreatment prognostic factors may predict the outcome of patients who receive decitabine therapy for MDS. Cancer 2007. © 2006 American Cancer Society.