bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbiome Derived Nanomaterials for Improved Pulmonary Delivery:
Recent Advancements and Future Prospects
Authors: Singh Dilpreet 
Published: March 2024

Abstract:
The human microbiome, comprising a complex community of microorganisms, has
emerged as a crucial factor in maintaining health and influencing disease states. Recently, there has
been growing interest in harnessing the potential of microbiome-based nanomaterials for enhanced
pulmonary drug delivery. This abstract presents an overview of recent advancements and prospects
in this field. Microbiome-based nanomaterials offer a targeted and personalized approach to pulmonary delivery, leveraging an understanding of the lung microbiome. These nanomaterials can be engineered to encapsulate drugs or therapeutic agents, modulate the lung microbiome, act as diagnostic
tools, regulate immune responses, and facilitate vaccine delivery. While significant progress has been
made, challenges, such as formulation stability, safety, efficacy, and regulatory considerations, need
to be addressed for successful translation into clinical practice. With continued research and technological advancements, microbiome-based nanomaterials hold great promise in revolutionizing pulmonary healthcare, providing novel strategies for the treatment and prevention of respiratory diseases.
Exacerbation of Mirror Movement Disorder: A Complex Case of Childhood-onset Mirror Movements Aggravated by Essential Tremors, and Parkinson's Disease
Authors: Zarei Sara , Nasouri Farnoush , Kamali Setareh , Patel Shivani , Jamil Rahma , Amaar Ayymen Y , Mohamed Ahmed , Zarei Rojeen , Altamimi Sadiq 
Published: March 2024

Background
Mirror movement (MM), also known as bimanual synkinesis, is characterized by simultaneous involuntary movements of homologous muscles accompanying voluntary movements of contralateral body regions. MM can be observed in various neurological conditions, including cerebral palsy, corticobasal syndrome, Parkinson's disease, certain types of symptomatic epilepsies, Creutzfeldt-Jakob's disease, Huntington's disease, and others.

Case Description
A 52-year-old female with a history of epileptic seizures, essential tremors and mild MM was presented to a neurology clinic for seizure management. She had a long-standing history of seizures since childhood. Initial neurological examination revealed mild MM disorder. During the follow up visits, patient’s mirror movements were exacerbated months before she was diagnosed with Parkinson’s disease. Multiple antiepileptic drug regiments along with Carbidopa-levodopa were used and dose adjustments were done during follow up visits to help stabilize the patient’s symptoms.

Conclusion
In conclusion, this case highlights the progressive nature of mirror movement disorder (MMD) and its association with other neurological conditions, such as epilepsy, essential tremors, and Parkinson's disease. The primary aim of this study was to showcase that individuals with early childhood onset of MMD may experience a deterioration of their condition as they acquire additional neurological disorders, such as essential tremors or Parkinson's disease. Moreover, this study seeks to elucidate how the exacerbation of mirror movement symptoms in such cases can serve as an early indicator of the onset of Parkinson's disease. Medication adjustments played a crucial role in managing the patient's symptoms, emphasizing the importance of individualized treatment plans and close monitoring.
A Study of how the Serum Levels of Inflammatory Markers Correlate with Hemoglobin Oxygen Saturation Percentage and the Type of Respiratory Support Received by Covid-19 Patients Hospitalized in Intensive Care Units
Authors: Moghadaci Ali , Saghari Sam , Abbasi Zahra , Zandieh Mohammad Arad , Gholami Mohammad Hossein , Hushmandi Kiavash , Rudi Abdolqayum Movahedi , Raesi Rasoul 
Published: March 2024

Aim
This study aimed to shed light on how serum levels of interleukin-6 (IL-6), lactate dehydrogenase (LDH), and C-reactive protein (CRP) correlate with hemoglobin oxygen saturation percentage (SpO2) and the type of respiratory support received among COVID-19 patients hospitalized in COVID-19 intensive care units.

Background
The clinical care of patients who suffer from COVID-19 requires knowledge of laboratory findings and the way these findings are linked with the type of respiratory support.

Methods
This descriptive-analytical study was conducted using data from the clinical records of 31 patients hospitalized in the intensive care unit at 22nd-Bahman Hospital in Khaf, Eastern Iran, during the first half of 2021. The study utilized a checklist developed by the researcher for data collection. The data were analyzed with Kolmogorov-Smirnov, independent t, one-way analysis of variance, and Tukey's post hoc statistical tests in the SPSS-22 statistical package. The significance level was established at p <0.05.

Results
The mean CRP, LDH, and serum levels of IL-6 were significantly higher in COVID-19 patients with SpO2 <93 than in patients with SpO2 ≥93 (p <0.05). Patients receiving intubation and non-invasive respiratory support exhibited significantly greater serum levels of IL-6, CRP, and LDH than patients receiving other respiratory support (p <0.05). The mean CRP, serum levels of IL-6, and LDH were significantly lower among survivors than those who died (p <0.01).

Conclusion
Understanding the relationship between the serum levels of IL-6, CRP, LDH, and SPO2 and the type of respiratory support can help predict the management of acute respiratory patients, but this decision-making method based on serum levels should be further investigated. and to be compared with the current methods of management of treatment of acute respiratory patients.
SYNERGISTIC DRUG COMPATIBILITY OF SUMATRIPTAN SUCCINATE AND METOCLOPRAMIDE HYDROCHLORIDE (IN SITU GEL FORMULATIONS) FOR NASAL DRUG RELEASE OPTIMIZATION
Authors: RIYA V KALEBAR  , PANKAJ GAJARE  , MAMLE DESAI SN  , VISHAL U KALEBAR  , RAVINDRANATH H ALADAKATTI  
Published: March 2024

Objective: Migraine is a prevalent neurological condition that causes lifelong tenacious headaches and significantly impacts the daily lives of individuals. Despite being frequently underestimated or neglected, it affects the individual’s routine activities, performance, self-confidence, and identity. Treatment often involves the administration of painkillers, which can lead to various complications. This study aimed to develop and characterize an in situ nasal formulation of sumatriptan succinate and metoclopramide hydrochloride to enhance drug residence time in the nasal cavity and improve drug bioavailability.
Methods: Eight formulations of intranasal in situ gels were prepared using the “Cold Method” and evaluated for various parameters, including appearance, texture, viscosity, pH, gel strength, gelation temperature, drug content, and in vitro/ex vivo drug diffusion. FT-IR studies confirmed no interactions between sumatriptan succinate, metoclopramide hydrochloride, and the excipients. Simultaneous estimation method was used to evaluate drug content, in vitro and ex vivo drug diffusion.
Results: Among the formulations, “Sumatriptan Succinate Metoclopramide Hydrochloride Polymer (SMP8)” exhibited the most favorable characteristics. The percent cumulative drug release was determined to be 96.803±0.0015 for sumatriptan succinate and 92.569±0.0028 for metoclopramide hydrochloride, aligning with the Higuchi model kinetics. In vitro and ex vivo diffusion studies demonstrated that SMP8 provided sustained drug release for up to 9 h, making it the optimal dosage formulation for nasal drug delivery in the treatment of migraine.
Conclusion: This study’s findings suggest that the developed intranasal in situ gel formulation, SMP8, effectively releases sumatriptan succinate and metoclopramide hydrochloride over an extended period. By improving drug residence time and bioavailability, this formulation has the potential to enhance the therapeutic efficacy and patient compliance in the management of migraine.
HIGH-RESOLUTION COMPUTED TOMOGRAPHY IN DIAGNOSING AND MONITORING VARIOUS INTERSTITIAL LUNG DISEASES
Authors: BHARAT JAIN  , KAPIL VYAS  , SRISHTI  , MANISH ASUDANI  , KARISHMA JARIWALA  
Published: March 2024

Objective: Interstitial lung diseases (ILDs) are difficult to diagnose and require accurate imaging methods. The purpose of this work is to investigate ILD patterns and their relationships to pulmonary function using high-resolution computed tomography (HRCT). The aim is to augment our comprehension of ILDs, thereby facilitating customized approaches to diagnosis and treatment
Methods: We recruited 50 ILD patients with radiological and clinical issues for a single-center trial. Spirometric data, symptoms, and demographics were recorded on comprehensive patient proformas. An expert radiologist used a Siemens-Somatom 6-slice CT scanner to analyze the HRCT. Pulmonary function indices were obtained using spirometry, which was carried out using a Medisoft Spiro Air spirometer.
Results: In fifty cases with ILD, common features on HRCT were uneven pleural borders, ground glass opacities, and septal/subpleural lines. The complex interaction between radiological symptoms and respiratory health was highlighted by the substantial correlations seen between HRCT severities; extent scores, and reduced pulmonary function.
Conclusion: The study reinforces the necessity for individualized diagnostic and treatment methods in the ILD respiratory landscape by providing detailed insights into their disease patterns and relationships.
COMPARATIVE STUDY OF INTRAVENOUS PARACETAMOL AND INTRAVENOUS DICLOFENAC ANALGESIA WITH RESPECT TO EFFECT ON RENAL FUNCTION, BLEEDING TIME, AND CLOTTING TIME IN POST-OPERATIVE CASES UNDERGOING LSCS UNDER SPINAL ANESTHESIA
Authors: JULIE PHILIPOSE BABY  , ASHWINI MOTICHAND SHAH  
Published: March 2024

Objectives: The aims and objectives of the study are to compare paracetamol and diclofenac for post-operative analgesia, efficacy, and safety profiles in patients undergoing LSCS under spinal anesthesia.
Methods: Fifty-eight patients undergoing LSCS under spinal anesthesia were included in this study. Out of these 58 patients, 30 patients received paracetamol (Group P) and the remaining 28 patients received diclofenac (Group D). Post-operative pain was assessed using the Visual Analog Scale. Rescue analgesic used was buprenorphine intravenous at a dose of 1 mg/kg. Injection buprenorphine was given to the patient with a VAS score of more than three in addition to the routine dose of the study drug. Pre-operative and post-operative values of blood urea, serum creatinine, bleeding time, and clotting time were compared in both groups. p<0.05 were taken as statistically significant.
Results: The mean age of patients in both groups was found to be comparable with no statistically significant difference (p=0.3849). In post-operative period at 150, 180 min, and 210 min, Group P reported significantly higher pain scores as compared to Group D with p-values indicating statistical significance (p<0.05). The analysis of pre- and post-operative renal function tests, bleeding time, and clotting time showed that there was no significant difference in the pre- and post-operative renal function tests, bleeding time, and clotting time of the patients in Group P and Group D.
Conclusion: Intravenous diclofenac is found to have a superior analgesic effect as compared to intravenous paracetamol. Both paracetamol and diclofenac were found to have no significant side effects on renal functions, bleeding time, or clotting time.
PENINGKATAN RELASI SOSIAL MELALUI SOCIAL SKILL THERAPY PADA PENDERITA SCHIZOPHRENIA KATATONIK
Authors: Hidayati Diana Savitri 
Published: March 2024

Angka penderita Schizophrenia di Indonesia pada 25 tahun yang lalu diperkirakan 1/1000 penduduk dengan proyeksi 25 tahun mendatang mencapai 3/1000 penduduk. Seorang penderita schizophrenia harus didorong untuk bergaul dengan orang lain dengan maksud agar ia tidak mengasingkan diri lagi, karena bila menarik diri penderita dapat membentuk kebiasaan yang kurang baik. Social skills therapy berguna untuk meningkatkan kemampuan sosial, kemampuan memenuhi diri sendiri, latihan praktis dan komunikasi interpersonal. Penelitian ini bertujuan untuk melihat efek dari penerapan Social skills therapy kepada penderita Schizophrenia katatonik terutama terhadap relasi sosialnya. Penelitian ini menggunakan metode penelitian berupa studi kasus. Hasil pelaksanaan social skills therapy adalah subyek penelitian mampu menunjukkan respon berupa uluran tangan untuk berjabat tangan dan subyek mampu mengadakan interaksi timbal balik berupa senyuman ketika diberi pertanyaan. Sessi terapi yang sempat terhenti menyebabkan perubahan yang telah terbentuk pada subyek kembali seperti semula saat terapi belum dilaksanakan. Hasil dari intervensi berupa social skills therapy akan lebih baik bila sessi terapi dilaksanakan secara berkesinambungan dan pihak keluarga juga ikut berperan aktif dalam pelaksanaan terapi. Kata kunci: Relasi sosial, social skill therapy, penderita schizophrenia katatonik. Number of people with Schizophrenia in Indonesia in the last 25 years is estimated to 1/1000 with a projected population of 25 years reaches 3/1000 population. A person with schizophrenia should be encouraged to get along with others with the intention that he does not alienate himself, because when he pulled away he can form bad habits. Social skills therapy is useful for improving social skills , ability to meet yourself, practical exercises and interpersonal communication. This study aimed to examine the effects of the adoption of the Social skills therapy to patients with catatonic schizophrenia , especially the social relations . This study uses a case study research . The results of the implementation of social skills therapy are able to study subjects showed a response in the form of a helping hand to shake hands and the subjects were able to hold a reciprocal interaction in the form of a smile when asked a question . Therapy session was stopped cause changes that have formed on the subject back to normal when therapy has not been implemented . Results of a social skills intervention therapy would be better if the therapy sessions conducted continuously and the family also play an active role in the implementation of the therapy . Keyword: Job satisfaction, adaptability, employees
INTENSI PERILAKU PROSOSIAL ANAK DITINJAU DARI GAYA PENGASUHAN
Authors: Utomo Dailinar 
Published: March 2024

Perilaku anak dibentuk melalui gaya pengasuhan orang tua. Adanya penelitian yang menyatakan bahwa perilaku yang diharapakan oleh orang tua pada anaknya adalah perilaku prososial menyebabkan penelitian ini bertujuan untuk mengetahui perbedaan intensi perilaku prososial anak dari setiap gaya pengasuhan. Penelitian ini bersifat kuantitiatif dengan menggunakan forced choice scale. Subyek penelitian adalah anak berusia 10-12 tahun atau siswa kelas 5 dan 6 sekolah dasar berjumlah 60 anak untuk setiap gaya pengasuhan, yaitu pengasuhan otoriter, pengasuhan otoritatif, pengasuhan permisif indulgen dan pengasuhan permisif indeferen. Penelitian ini analisis dengan One Way Anova untuk menentukan tingkat perbedaan intensi perilaku prososial anak dari setiap gaya pengasuhan. Berdasarkan penelitian yang dilakukan diperoleh data bahwa pengasuhan otoritatif mempunyai nilai mean sebesar 68,82, pengasuhan permisif indeferen mempunyai nilai mean sebesar 64,48, pengasuhan permisif indulgen mempunyai nilai mean 63,57 dan pengasuhan otoriter mempunyai nilai mean 63,57. Dari penelitian ini dapat diketahui bahwa pengasuhan otoritatif mempunyai nilai mean prososial tertinggi sedangkan pengasuhan otoriter mempunyai nilai mean prososial terendah, dengan perbedaan mean 5,25 dan dengan taraf signifikansi sebesar 0,00. Kata kunci: Intensi perilaku prososial anak, gaya pengasuhan The behavior of children created through parenting style. The study suggesting that the behavior expected by the parents on the child's behavior prososial cause this research aims to know the difference in the behavior of children prososial intention every parenting style. This reasearch is using quantitative methode with use forced choice scale. Research subjects are children aged 10-12 years or students in 5th grade and 6th grade of elementary school totaled 60 children for every parenting style, which is the authoritarian parenting, authoritative parenting, permissive indulgen parenting and permissive indeferen parenting. This research analysis with one way anova to determine degree of difference child's intention behavior prososial every parenting style. Based on research conducted obtained data that authoritative parenting style have mean value 68.82, permissive indeferen parenting have mean valaue 64.48, permissive indulgen parenting have mean 63.57, and authoritarian parenting have mean 63.57. From this research it is known that authoritative parenting can have values mean the highest prososial While the authoritarian parenting style has a value of mean lowest prososial, With corresponding differences in the mean 5.25 and with 0.00 degree of significance Keyword: Intention of prosocial behaviour, parenting style
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS ANDROID PADA MATERI MENULIS HURUF HIRAGANA DI LPK JIEMA KOTA METRO
Authors: Rusprianti Ni Wayan , Andayani Sutrisni , Sudirman Sudirman 
Published: March 2024

Tujuan dalam penelitian ini adalah menghasilkan media pembelajaran macromedia flash pada materi menulis huruf hiragana di LPK Jiema Kota Metro dan mengetahui tingkat kevalidan media pembelajaran macromedia flash dalam meningkatkan kemampuan menulis huruf hiragana di LPK Jiema Kota Metro. Jenis penelitian ini merupakan penelitian pengembangan. Penelitian pengembangan ini menggunakan model pengembangan ADDIE yang meliputi Analisis, Desain, Development, Implementation dan Evaluation. Analisis yang dilakukan pada penelitian ini yaitu dengan cara mengelompokan jenis-jenis data yang diperoleh sehingga peneliti mudah memahami data dan menarik kesimpulan. Dalam pengembangan ini produk yang dihasilkan berupa media pembelajaran macromedia flash pada materi huruf hiragana dalam bentuk aplikasi. Berdasarkan hasil penelitian pengembangan dengan melalui beberapa tahapan maka peneliti menyimpulkan dari hasil penelitian diantaranya: Penelitian pengembangan ini menghasilkan produk media pembelajaran macromedia flash pada materi huruf hiragana untuk peserta pelatihan kerja di LPK Jiema Kota Metro. Media pembelajaran ini berbentuk aplikasi macromedia flash yang memuat materi, langkah-langkah cara menulis huruf hiragana yang benar dan sesuai kaidah penulisan huruf jepang. Hasil penelitian yang diperoleh menunjukkan bahwa media pembelajaran macromedia flash pada materi menulis huruf hiragana yang dikembangkan valid dan layak digunakan sebagai media pembelajaran untuk peserta pelatihan dalam proses kegiatan pembelajaran. Hal ini terlihat dari persentase uji ahli media sebesar 91,3%, pada uji ahli materi sebesar 89,8%, dan uji soal sebesar 89,7 dari ketiga uji validator tersebut ketiga uji masuk dalam kategori sangat baik.

Kata Kunci: huruf hiragana, macromedia flash, pengembangan
POLA AJAR ORANG TUA TUA TERHADAP ANAK BERKEBUTUHAN KHUSUS (BUTA TOTAL, TULI, DAN CACAT FISIK) EDUCATING PATTERNS FOR CHILDREN WITH SPECIAL NEEDS (BLIND, DEAF, AND PHYSICALLY DISABLED)
Authors: Azizah Awalia Nur , Nurwati R Nunung , Santoso Meilanny Budiarti 
Published: March 2024

Undang-Undang Nomor 20 Tahun 2003 tentang Sistem Pendidikan Nasional menjelaskan bahwa pendidikan dapat dilakukan melalui tiga cara, yakni pendidikan formal, pendidikan non formal, dan pendidikan informal. Tanggung jawab pendidikan di dalam keluarga khususnya orang tua termasuk ke dalam pendidikan informal. Untuk melaksanakan pendidikan informal, keluarga memberikan bentuk pengajaran yang akan sangat berpengaruh dalam perkembangan seorang anak berkebutuhan khusus. Oleh karena itu, keluarga harus menyesuaikan pola ajar yang akan diberikan kepada anak berkebutuhan khusus dengan ciri-ciri yang dimiliki, khususnya anak yang terkena buta total, tuli, dan cacat fisik. Law Number 20 of 2003 concerning the National Education System explains that education can be carried out in three ways, namely formal education, non-formal education, and informal education. Educational responsibilities in the family, especially parents, are included in informal education. To carry out informal education, the family provides a form of teaching that will be very influential in the development of a child with special needs. Therefore, families must adjust the teaching patterns that will be given to children with special needs with their characteristics, especially children who are completely blind, deaf, and physically disabled.
PENGARUH PEER-GROUP TERHADAP PERKEMBANGAN SELF-ESTEEM REMAJA The Influence of Peer Groups on the Development of Adolescent Self-Esteem
Authors: Nurul Asyia Arifah Di’Faeni , Sinurat Gabriela Dameni Natalia , Aufa Dianto Nurul Izza Sayyidina , Apsari Nurliana Cipta 
Published: March 2024

AbstrakMasa remaja identik dengan proses pencarian jati diri setiap individu di mana, banyak sekali aspek di dalam diri seseorang yang mengalami perubahan pada proses tersebut. Sulit bagi remaja untuk melalui fase ini seorang diri, terutama dalam menghadapi dinamika-dinamika pendewasaan yang ada. Untuk itu, remaja akan berusaha mencari dukungan sosial dari sumber-sumber dukungan di sekitarnya. Namun, sumber dukungan primer dari orang tua cenderung akan dilepaskan perlahan-lahan oleh remaja dan beralih kepada sumber dukungan dari teman sebaya. Sumber dukungan dari teman sebaya itu bisa didapatkan remaja melalui peer group. Peer group memiliki pengaruh yang besar dalam diri remaja dalam pembentukan identitas di mana self-esteem juga termasuk di dalamnya. Self-esteem merupakan salah satu komponen penting yang dimiliki setiap individu dalam pembentukan karakter. Artikel ini akan membahas mengenai pengaruh dari peer group pada pembentukan self-esteem pada remaja. Penulis menggunakan metode studi kepustakaan dalam penulisan artikel ini untuk memaparkan mengenai self-esteem pada remaja, peran peer group bagi remaja, dan pengaruh dari peer group pada pembentukan self-esteem pada remaja. AbstractAdolescence is identical with the process of finding the identity of each individual where there are many aspects in a person who experience changes in the process. It is difficult for teenagers to go through this phase alone, especially in dealing with the existing dynamics of maturation. For this reason, adolescents will try to find social support from support sources around them. However, the primary source of support from parents tends to be released slowly by adolescents and turns to sources of support from peers. The source of support from peers can be obtained by teenagers through peer groups. Peer groups have a great influence on adolescents in the formation of identity in which self-esteem is also included. Self-esteem is one of the important components that every individual has in character building. This article will discuss the influence of peer groups on the formation of self-esteem in adolescents. The author uses the literature study method in writing this article to describe self-esteem in adolescents, the role of peer groups for adolescents, and the influence of peer groups on the formation of self-esteem in adolescents.