bluuebunny/crossref_metadata_2025_split huggingface dataset:
La santé des anciens : ralentissement et innovation
Authors: AUSSILLOU BOUREAU Manon 
Published: April 2024

Dans le cadre d’un partenariat avec une collectivité territoriale, des chercheurs mettent en œuvre avec les acteurs de terrain une recherche-intervention (désormais RI). Le tiers-espace socio-scientifique (espace d’intersection entre la sphère recherche et la sphère socio-professionnelle) réunit les acteurs qui permettent d’accompagner le changement en EHPAD en co-construisant un dispositif à visée inclusive. Cet espace intersectionnel permet de médiatiser la rencontre entre les mondes au sein des groupes de travail et du comité de pilotage de la RI, de favoriser le métissage des savoirs académiques et expérientiels et de mettre en réflexion et en chantier des situations problèmes pour favoriser l’inclusion des anciens. Sur deux niveaux, la démarche permet un ralentissement encourageant l’innovation sociale et soutenant une nouvelle modalité de construction des politiques publiques : (1) au niveau de la production de la politique publique et (2) au niveau des conditions de production de celle-ci. Dès lors, le ralentissement induit par la démarche de RI peut être considéré comme un facteur favorisant l’innovation sociale en EHPAD et, en conséquence le droit à la santé des anciens.
Financial stability of Ukraine's economy during the war and post-war periods: challenges and drivers of recovery
Authors: Zhytar Maksym 
Published: April 2024

The article highlights the issues related to the challenges and drivers of recovery of the economy of Ukraine in the war and post-war periods. It is noted that since the beginning of the full-scale invasion of the Russian Federation on the territory of Ukraine, our country has lost significant human resources and witnessed the destruction of critical, industrial and social structures. The hostilities continue, but the belief in victory prompts scholars and practitioners to discuss the formats of reconstruction and modernization of the country after the war.
Directions of economic recovery are proposed, namely: reconstruction and restoration of war-damaged property and infrastructure; quick recovery of economic processes; return of refugees and internally displaced persons back to Ukraine and their inclusion in economic processes; creating the foundations for sustainable economic growth. It has been concluded that, in general, the recovery of the economy of Ukraine, which suffered from the war, can be a driver of the recovery of infrastructure and revival of the industrial sector, creation of new jobs and support of small and medium enterprises, reconstruction of the housing stock, restoration of social infrastructure and development of the sphere of social services, social rehabilitation of war victims and restoration of the natural environment.
THE MODEL OF STRATEGIC MANAGEMENT OF A RELIGIOUS TOURISM DESTINATION IN FUNCTION OF SUSTAINABLE DEVELOPMENT
Authors: Korov Tomislav , Šostar Marko , Andrlić Berislav 
Published: April 2024

Objective: This study aims to explore the significance and potential of religious tourism in Croatia for sustainable development, highlighting the absence of a strategic approach in managing this tourism sector. The primary goal is to assess the current state of religious tourism, identify challenges, and recommend strategic directions for enhancing religious tourism destinations.

Theoretical Framework: The research is anchored in the theories and models of sustainable development, tourism management, and cultural heritage preservation. These theories provide a comprehensive understanding of how religious tourism can contribute to economic growth, cultural preservation, and community engagement in a sustainable manner.

Method: Employing survey research and analysis of relevant resources, this study systematically examines the current landscape of religious tourism in Croatia. It focuses on stakeholder coordination, promotion strategies, infrastructure development, and cultural heritage preservation efforts.

Results and Discussion: The investigation reveals a fragmented approach to managing religious tourism, characterized by poor coordination among stakeholders, inadequate promotion, underdeveloped infrastructure, and challenges in cultural heritage preservation. These findings suggest that a more cohesive and strategic approach could significantly bolster sustainable development, enhance economic opportunities in rural locales, and foster cultural heritage appreciation.

Research Implications: The study underscores the necessity for stronger collaboration among religious communities, tourism organizations, and governmental authorities. It advocates for enhanced promotional efforts, infrastructure investments, and robust measures for cultural and religious heritage conservation, offering valuable insights for policymakers, tourism developers, and community leaders.

Originality/Value: This paper contributes original insights into the underexplored domain of religious tourism in Croatia, offering a structured analysis of its current state and potential for sustainable development. Its strategic recommendations provide a foundation for future initiatives to harness religious tourism as a vehicle for economic and cultural sustainability in Croatia.
Predicting patient-specific organ doses from thoracic CT examinations using support vector regression algorithm
Authors: Shao Wencheng , Lin Xin , Huang Ying , Qu Liangyong , Zhuo Weihai , Liu Haikuan 
Published: April 2024

PURPOSE: This study aims to propose and develop a fast, accurate, and robust prediction method of patient-specific organ doses from CT examinations using minimized computational resources. MATERIALS AND METHODS: We randomly selected the image data of 723 patients who underwent thoracic CT examinations. We performed auto-segmentation based on the selected data to generate the regions of interest (ROIs) of thoracic organs using the DeepViewer software. For each patient, radiomics features of the thoracic ROIs were extracted via the Pyradiomics package. The support vector regression (SVR) model was trained based on the radiomics features and reference organ dose obtained by Monte Carlo (MC) simulation. The root mean squared error (RMSE), mean absolute percentage error (MAPE), and coefficient of determination (R-squared) were evaluated. The robustness was verified by randomly assigning patients to the train and test sets of data and comparing regression metrics of different patient assignments. RESULTS: For the right lung, left lung, lungs, esophagus, heart, and trachea, results showed that the trained SVR model achieved the RMSEs of 2 mGy to 2.8 mGy on the test sets, 1.5 mGy to 2.5 mGy on the train sets. The calculated MAPE ranged from 0.1 to 0.18 on the test sets, and 0.08 to 0.15 on the train sets. The calculated R-squared was 0.75 to 0.89 on test sets. CONCLUSIONS: By combined utilization of the SVR algorithm and thoracic radiomics features, patient-specific thoracic organ doses could be predicted accurately, fast, and robustly in one second even using one single CPU core.
Forensic Psychiatric Examination: General Theoretical Issues
Authors: Makarova Olena 
Published: April 2024

The article outlines the issue of appointing and conducting a forensic examination in Ukraine, specifically focusing on forensic psychiatric examination. It presents the key concepts and terms related to forensic psychiatric examination, along with its tasks, types, procedures, and significance for the judicial process. The conclusion drawn is that expert conclusions constitute a vital form of evidence in court proceedings, enabling the determination of case circumstances that may not be established through any other means.
The current state of appointment and conduct of forensic psychiatric examinations in Ukraine has been analyzed, existing problems have been identified and ways of solving them have been considered.
It has been established that the main problem in appointing and conducting a forensic psychiatric examination is that it is a complex and multifaceted type of forensic examination, which requires highly qualified and experienced forensic experts, but currently, there is a shortage of qualified psychiatric experts. This might result in a forensic examination being conducted improperly or with infringements.
The paper specifies the need for advanced training and acquisition of experience by forensic experts conducting forensic psychiatric examinations to ensure conclusions’ objectivity. The author concludes that forensic psychiatric examination requires the forensic expert to possess high professionalism, objectivity, independence, honesty, responsibility, competence, and tactfulness.
The article highlights the main concepts and terms associated with the appointment and conduct of a forensic psychiatric examination; describes the procedure for conducting a forensic psychiatric examination; reveals the importance of a forensic psychiatric examination for the judicial process; analyzes the current state of appointment and conduct of a forensic psychiatric examination in Ukraine; identifies the main problems associated with the appointment of a forensic psychiatric examination; considers possible recommendations for solving these problems. The author also draws attention to the importance of observing the rights and freedoms of persons who are the subject of forensic psychiatric examination.
Effective synthesis of circRNA via a thermostable T7 RNA polymerase variant as the catalyst
Authors: He Wei , Zhang Xinya , Zou Yangxiaoyu , Li Ji , Chang Le , He Yu-Cai , Jin Qiuheng , Ye Jianren 
Published: April 2024

Introduction:Circular RNAs (circRNAs) are endogenous noncoding RNAs (ncRNAs) with transcriptional lengths ranging from hundreds to thousands. circRNAs have attracted attention owing to their stable structure and ability to treat complicated diseases. Our objective was to create a one-step reaction for circRNA synthesis using wild-type T7 RNA polymerase as the catalyst. However, T7 RNA polymerase is thermally unstable, and we streamlined circRNA synthesis via consensus and folding free energy calculations for hotspot selection. Because of the thermal instability, the permuted intron and exon (PIE) method for circRNA synthesis is conducted via tandem catalysis with a transcription reaction at a low temperature and linear RNA precursor cyclization at a high temperature.Methods:To streamline the process, a multisite mutant T7 RNA polymerase (S430P, N433T, S633P, F849I, F880Y, and G788A) with significantly improved thermostability was constructed, and G788A was used.Results:The resulting mutant exhibited stable activity at 45°C for over an hour, enabling the implementation of a one-pot transcription and cyclization reaction. The simplified circRNA production process demonstrated an efficiency comparable to that of the conventional two-step reaction, with a cyclization rate exceeding 95% and reduced production of immunostimulatory dsRNA byproducts.
Plasma GFAP, NfL and pTau 181 detect preclinical stages of dementia
Authors: Ingannato Assunta , Bagnoli Silvia , Mazzeo Salvatore , Giacomucci Giulia , Bessi Valentina , Ferrari Camilla , Sorbi Sandro , Nacmias Benedetta 
Published: April 2024

BackgroundPlasma biomarkers are preferable to invasive and expensive diagnostic tools, such as neuroimaging and lumbar puncture that are gold standard in the clinical management of Alzheimer’s Disease (AD). Here, we investigated plasma Glial Fibrillary Acidic Protein (GFAP), Neurofilament Light Chain (NfL) and Phosphorylated-tau-181 (pTau 181) in AD and in its early stages: Subjective cognitive decline (SCD) and Mild cognitive impairment (MCI).Material and methodsThis study included 152 patients (42 SCD, 74 MCI and 36 AD). All patients underwent comprehensive clinical and neurological assessment. Blood samples were collected for Apolipoprotein E (APOE) genotyping and plasma biomarker (GFAP, NfL, and pTau 181) measurements. Forty-three patients (7 SCD, 27 MCI, and 9 AD) underwent a follow-up (FU) visit after 2 years, and a second plasma sample was collected. Plasma biomarker levels were detected using the Simoa SR-X technology (Quanterix Corp.). Statistical analysis was performed using SPSS software version 28 (IBM SPSS Statistics). Statistical significance was set at p &lt; 0.05.ResultsGFAP, NfL and pTau 181 levels in plasma were lower in SCD and MCI than in AD patients. In particular, plasma GFAP levels were statistically significant different between SCD and AD (p=0.003), and between MCI and AD (p=0.032). Plasma NfL was different in SCD vs MCI (p=0.026), SCD vs AD (p&lt;0.001), SCD vs AD FU (p&lt;0.001), SCD FU vs AD (p=0.033), SCD FU vs AD FU (p=0.011), MCI vs AD (p=0.002), MCI FU vs AD (p=0.003), MCI FU vs AD FU (p=0.003) and MCI vs AD FU (p=0.003). Plasma pTau 181 concentration was significantly different between SCD and AD (p=0.001), MCI and AD (p=0.026), MCI FU and AD (p=0.020). In APOE ϵ4 carriers, a statistically significant increase in plasma NfL (p&lt;0.001) and pTau 181 levels was found (p=0.014). Moreover, an association emerged between age at disease onset and plasma GFAP (p = 0.021) and pTau181 (p &lt; 0.001) levels.Discussion and conclusionsPlasma GFAP, NfL and pTau 181 are promising biomarkers in the diagnosis of the prodromic stages and prognosis of dementia.
Upscaling marine forest restoration: challenges, solutions and recommendations from the Green Gravel Action Group
Authors: Wood Georgina Valentine , Filbee-Dexter Karen , Coleman Melinda Ann , Valckenaere Jurgen , Aguirre J. David , Bentley Paige M. , Carnell Paul , Dawkins Phoebe Damayanthi , Dykman Lauren N. , Earp Hannah S. , Ennis Leeann B. , Francis Prue , Franco João N. , Hayford Hilary , Lamb Joleah B. , Ling Scott Douglas , Layton Cayne , Lis Ella , Masters Beau , Miller Nicole , Moore Pippa Jane , Neufeld Chris , Pocklington Jacqueline B. , Smale Dan , Stahl Florian , Starko Samuel , Steel S. Clay , Verbeek Jan , Vergés Adriana , Wilding Catherine M. , Wernberg Thomas 
Published: April 2024

IntroductionTo counteract the rapid loss of marine forests globally and meet international commitments of the UN Decade on Ecosystem Restoration and the Convention on Biological Diversity ‘30 by 30’ targets, there is an urgent need to enhance our capacity for macroalgal restoration. The Green Gravel Action Group (GGAG) is a global network of 67 members that are working on the restoration of a diverse range of macroalgal forests and it aims to facilitate knowledge exchange to fast-track innovation and implementation of outplanting approaches worldwide.MethodsHere, we overview 25 projects conducted by members of the group that are focused on testing and developing techniques for macroalgal restoration. Based on these projects, we summarise the major challenges associated with scaling up the area of marine forests restored.ResultsWe identify several critical challenges that currently impede more widespread rollout of effective large-scale macroalgal restoration worldwide: 1) funding and capacity limitations, 2) difficulties arising from conditions at restoration sites, 3) technical barriers, and 4) challenges at the restoration-policy interface.DiscussionDespite these challenges, there has been substantial progress, with an increasing number of efforts, community engagement and momentum towards scaling up activities in recent years. Drawing on the collective expertise of the GGAG, we outline key recommendations for the scaling up of restoration efforts to match the goals of international commitments. These include the establishment of novel pathways to fund macroalgal restoration activities, building skills and capacity, harnessing emerging innovations in mobile hatchery and seeding technologies, and the development of the scientific and governance frameworks necessary to implement and monitor macroalgal restoration projects at scale.
Next-generation sequencing survey of acute febrile illness in Senegal (2020–2022)
Authors: Orf Gregory S. , Ahouidi Ambroise D. , Mata Maximillian , Diedhiou Cyrille , Mboup Aminata , Padane Abdou , Manga Noel Magloire , Dela-del Lawson Agbogbenkou Tevi , Averhoff Francisco , Berg Michael G. , Cloherty Gavin A. , Mboup Souleymane 
Published: April 2024

IntroductionAcute febrile illnesses (AFI) in developing tropical and sub-tropical nations are challenging to diagnose due to the numerous causes and non-specific symptoms. The proliferation of rapid diagnostic testing and successful control campaigns against malaria have revealed that non-Plasmodium pathogens still contribute significantly to AFI burden. Thus, a more complete understanding of local trends and potential causes is important for selecting the correct treatment course, which in turn will reduce morbidity and mortality. Next-generation sequencing (NGS) in a laboratory setting can be used to identify known and novel pathogens in individuals with AFI.MethodsIn this study, plasma was collected from 228 febrile patients tested negative for malaria at clinics across Senegal from 2020–2022. Total nucleic acids were extracted and converted to metagenomic NGS libraries. To identify viral pathogens, especially those present at low concentration, an aliquot of each library was processed with a viral enrichment panel and sequenced. Corresponding metagenomic libraries were also sequenced to identify non-viral pathogens.Results and DiscussionSequencing reads for pathogens with a possible link to febrile illness were identified in 51/228 specimens, including (but not limited to): Borrelia crocidurae (N = 7), West Nile virus (N = 3), Rickettsia felis (N = 2), Bartonella quintana (N = 1), human herpesvirus 8 (N = 1), and Saffold virus (N = 1). Reads corresponding to Plasmodium falciparum were detected in 19 specimens, though their presence in the cohort was likely due to user error of rapid diagnostic testing or incorrect specimen segregation at the clinics. Mosquito-borne pathogens were typically detected just after the conclusion of the rainy season, while tick-borne pathogens were mostly detected before the rainy season. The three West Nile virus strains were phylogenetically characterized and shown to be related to both European and North American clades. Surveys such as this will increase the understanding of the potential causes of non-malarial AFI, which may help inform diagnostic and treatment options for clinicians who provide care to patients in Senegal.
Effects of recent cannabis consumption on eye-tracking and pupillometry
Authors: Haider Mohammad N. , Regan Daniel , Hoque Mahamudul , Ali Fahed , Ilowitz Andrew 
Published: April 2024

IntroductionCannabis consumption is known to immediately affect ocular and oculomotor function, however, cannabis consumption is also known to affect it for a prolonged period of time. The purpose of this study is to identify an eye tracking or pupillometry metric which is affected after recent cannabis consumption but is not confounded by cannabis consumption history or demographic variables.MethodsQuasi-experimental design. Participants who would consume inhalable cannabis (n = 159, mean age 31.0 years, 54% male) performed baseline neurobehavioral testing and eye-function assessments when they were sober. Eye function assessments included eye-tracking [gaze (point of visual focus), saccades (smooth movement)] and pupillometry. Participants then inhaled cannabis until they self-reported to be high and performed the same assessment again. Controls who were cannabis naïve or infrequent users (n = 30, mean age 32.6 years, 57% male) performed the same assessments without consuming cannabis in between.ResultsCannabis significantly affected several metrics of pupil dynamics and gaze. Pupil size variability was the most discriminant variable after cannabis consumption. This variable did not change in controls on repeat assessment (i.e., no learning effect), did not correlate with age, gender, race/ethnicity, or self-reported level of euphoria, but did correlate with THC concentration of cannabis inhaled.DiscussionA novel eye-tracking metric was identified that is affected by recent cannabis consumption and is not different from non-users at baseline. A future study that assesses pupil size variability at multiple intervals over several hours and quantifies cannabis metabolites in biofluids should be performed to identify when this variable normalizes after consumption and if it correlates with blood THC levels.
Optimal homeostatic stress to maximize the homogeneity of adaptations to interval interventions in soccer players
Authors: Sheykhlouvand Mohsen , Gharaat Mohammadali 
Published: April 2024

This study examined the uniformity of adaptations in cardiorespiratory fitness and bio-motor abilities by analyzing individual responses to measures representing the mentioned qualities. Twenty-four male well-trained soccer players (Age = 26 ± 4 years; stature = 181 ± 3.8; Weight = 84 ± 6.1) were randomized to two groups performing short sprint interval training [sSIT (3 sets of 10 × 4 s all-out sprints with 20 s of recovery between efforts and 3 min of rest intervals between sets)] or a time-matched small-sided game [SSG (3 sets of 3 v 3 efforts in a 20 × 15 m area with 3 min of relief in-between)]. Before and after the 6-week training period, aerobic fitness indices, cardiac hemodynamics, and anaerobic power were assessed through a graded exercise test utilizing a gas collection system, noninvasive impedance cardiography, and a lower-body Wingate test, respectively. Also, sport-specific bio-motor abilities were determined by measuring linear speed, change of direction, and jumping ability. Comparing inter-individual variability in the adaptive changes by analyzing residuals in individual adaptations indicated that sSIT induces more uniform changes in the first and second ventilatory threshold (VT1 &amp; VT2), stroke volume, and peak power output across team members than SSG. SSG also yielded lower proportions of responders in V˙O2⁡max, VT1, VT2, peak, and average power output compared to sSIT. Additionally, the coefficient of variation in mean group changes in measures of aerobic fitness and bio-motor abilities in response to sSIT were lower than in SSG. Short sprint interval training induces more homogenized adaptations in measures of cardiorespiratory fitness and anaerobic power than small-sided games across team members.