bluuebunny/crossref_metadata_2025_split huggingface dataset:
CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms
Authors: Han Seong-Su , Peng Liangping , Chung Seung-Tae , DuBois Wendy , Maeng Sung-Ho , Shaffer Arthur L , Sporn Michael B , Janz Siegfried 
Published: June 2006

AbstractBackgroundGene-targeted iMycEμmice that carry a His6-tagged mouseMyc(c-myc)cDNA,MycHis, just 5' of the immunoglobulin heavy-chain enhancer, Eμ, are prone to B cell and plasma cell neoplasms, such as lymphoblastic B-cell lymphoma (LBL) and plasmacytoma (PCT). Cell lines derived from Myc-induced neoplasms of this sort may provide a good model system for the design and testing of new approaches to prevent and treat MYC-driven B cell and plasma cell neoplasms in human beings. To test this hypothesis, we used the LBL-derived cell line, iMycEμ-1, and the newly established PCT-derived cell line, iMycEμ-2, to evaluate the growth inhibitory and death inducing potency of the cancer drug candidate, CDDO-imidazolide (CDDO-Im).MethodsMorphological features and surface marker expression of iMycEμ-2 cells were evaluated using cytological methods and FACS, respectively. mRNA expression levels of the insertedMycHisand normalMycgenes were determined by allele-specific RT-PCR and qPCR. Myc protein was detected by immunoblotting. Cell cycle progression and apoptosis were analyzed by FACS. The expression of 384 "pathway" genes was assessed with the help of Superarray©cDNA macroarrays and verified, in part, by RT-PCR.ResultsSub-micromolar concentrations of CDDO-Im caused growth arrest and apoptosis in iMycEμ-1 and iMycEμ-2 cells. CDDO-Im-dependent growth inhibition and apoptosis were associated in both cell lines with the up-regulation of 30 genes involved in apoptosis, cell cycling, NFκB signaling, and stress and toxicity responses. Strongly induced (≥10 fold) were genes encoding caspase 14, heme oxygenase 1 (Hmox1), flavin-containing monooxygenase 4 (Fmo4), and three members of the cytochrome P450 subfamily 2 of mixed-function oxygenases (Cyp2a4, Cyp2b9, Cyp2c29). CDDO-Im-dependent gene induction coincided with a decrease in Myc protein.ConclusionGrowth arrest and killing of neoplastic mouse B cells and plasma cells by CDDO-Im, a closely related derivative of the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid, appears to be caused, in part, by drug-induced stress responses and reduction of Myc.
Analysis of airway secretions in a model of sulfur dioxide induced chronic obstructive pulmonary disease (COPD)
Authors: Wagner Ulrich , Staats Petra , Fehmann Hans-Christoph , Fischer Axel , Welte Tobias , Groneberg David A 
Published: June 2006

Abstract
Hypersecretion and chronic phlegm are major symptoms of chronic obstructive pulmonary disease (COPD) but animal models of COPD with a defined functional hypersecretion have not been established so far. To identify an animal model of combined morphological signs of airway inflammation and functional hypersecretion, rats were continuously exposed to different levels of sulfur dioxide (SO2, 5 ppm, 10 ppm, 20 ppm, 40 ppm, 80 ppm) for 3 (short-term) or 20–25 (long-term) days. Histology revealed a dose-dependent increase in edema formation and inflammatory cell infiltration in short-term-exposed animals. The submucosal edema was replaced by fibrosis after long-term-exposure. The basal secretory activity was only significantly increased in the 20 ppm group. Also, stimulated secretion was significantly increased only after exposure to 20 ppm. BrdU-assays and AgNOR-analysis demonstrated cellular metaplasia and glandular hypertrophy rather than hyperplasia as the underlying morphological correlate of the hypersecretion.
In summary, SO2-exposure can lead to characteristic airway remodeling and changes in mucus secretion in rats. As only long-term exposure to 20 ppm leads to a combination of hypersecretion and airway inflammation, only this mode of exposure should be used to mimic human COPD. Concentrations less or higher than 20 ppm or short term exposure do not induce the respiratory symptom of hypersecretion. The present model may be used to characterize the effects of new compounds on mucus secretion in the background of experimental COPD.
Impaired Sexual Activity in Male Adults with Partial Androgen Insensitivity
Authors: Bouvattier Claire , Mignot Brigitte , Lefèvre Hervé , Morel Yves , Bougnères Pierre 
Published: June 2006

Abstract
Context: Choosing the sex of rearing of an XY neonate with a major sexual ambiguity and a mutated androgen receptor remains one of the more difficult questions of neonatal endocrinology. A direct consequence of this choice is the accomplishment of sexual function in adulthood. There is very limited knowledge of the sexual performance of patients with partial androgen insensitivity syndrome.
Objective: The objective of this study is to describe physical acts of sexuality in partial androgen insensitivity syndrome patients reared as males.
Design: We were able to obtain factual information regarding the sexual activity of 15 adult patients who had been reared as males and followed at our institution since birth. We evaluated their sexual performance using two validated questionnaires (Golombok-Rust Inventory of Sexual Satisfaction and International Index of Erectile Dysfunction).
Results: We documented a major impairment of all parameters of sexual activity.
Conclusion: This long-term insight into the consequences of male sex assignment will have to be balanced by a study of the consequences of female sex assignment.
Recurrence of the R947X Mutation in Unrelated Families with Autosomal Dominant Pseudohypoaldosteronism Type 1: Evidence for a Mutational Hot Spot in the Mineralocorticoid Receptor Gene
Authors: Fernandes-Rosa Fabio L. , de Castro Margaret , Latronico Ana Claudia , Sippell Wolfgang G. , Riepe Felix G. , Antonini Sonir R. 
Published: June 2006

Abstract
Background: The renal form of pseudohypoaldosteronism type 1 (PHA1) is a rare disease characterized by congenital mineralocorticoid resistance of the kidney. Twenty-two different loss-of-function mutations in the mineralocorticoid receptor gene have been described in families with PHA1. These mutations were not recurrent and resulted in a large phenotypic variability.
Objective: The objective of this study is to analyze the recurrence of an inactivating mutation in the mineralocorticoid receptor gene in unrelated families with autosomal dominant PHA1.
Patients: Seventeen members from three unrelated families with autosomal dominant PHA1 were studied, including 11 affected patients with variable clinical manifestations. Fifty healthy subjects were used as controls.
Methods: Genomic DNA was extracted, and the entire coding region of the mineralocorticoid receptor gene was submitted to automatic sequencing. Four dinucleotide microsatellite markers spanning a region of 3.2 cM in the human mineralocorticoid receptor gene locus, and two intragenic polymorphisms were used for haplotype analysis.
Results: A heterozygous point mutation at codon 947 (c.2839C&gt;T) changing arginine to stop codon (R947X) was found in the three families. Different haplotypes segregated with the R947X mutation in each family, demonstrating the absence of a founder effect for this mutation.
Conclusion: Codon 947 of the mineralocorticoid receptor is the first mutational hot spot for autosomal dominant PHA1.
Ab initio Determination of Solid‐State Nanostructure.
Authors: Juhas P. , Cherba D. M. , Duxbury P. M. , Punch W. F. , Billinge S. J. L. 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Superconductivity in Li3Ca2C6 Intercalated Graphite.
Authors: Emery Nicolas , Herold Claire , Mareche Jean‐Francois , Bellouard Christine , Loupias Genevieve , Lagrange Philippe 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Temperature Dependences of Rhombohedral Lattice Distortion and of Ferromagnetic Uranium Ordering in the Uranium Monochalcogenides.
Authors: Herrmannsdoerfer T. , Fischer P. , Mattenberger K. , Vogt O. 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The First End‐On Bonded Superoxo Complexes of Ga and In: The Oxygen‐Rich Compounds GaO4 and InO4.
Authors: Gaertner Benjamin , Koehn Andreas , Himmel Hans‐Joerg 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Crystal Structure and Ionic Conductivity of a New Bismuth Tungstate, Bi3W2O10.5.
Authors: Muktha B. , Guru Row T. N. 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Formation of High Nuclearity Mixed‐Valent Polyoxovanadates in the Presence of Copper Amine Complexes.
Authors: Thomas Jency , Sharma Sanjeev , Lofland S. E. , Ramanujachary K. V. , Ramanan A. 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Active Iron Based Reducing System for Carbonyl Compounds and Imines. Stereoselective Reduction of Cyclic Ketones.
Authors: Moglie Yanina , Alonso Francisco , Vitale Cristian , Yus Miguel , Radivoy Gabriel 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cobalt‐Catalyzed Cross‐Coupling Reactions of Alkyl Halides with Aryl Grignard Reagents and Their Application to Sequential Radical Cyclization/Cross‐Coupling Reactions.
Authors: Ohmiya Hirohisa , Wakabayashi Katsuyu , Yorimitsu Hideki , Oshima Koichiro 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
One‐Step Reductive Amidation of Nitro Arenes: Application in the Synthesis of Acetaminophen.
Authors: Bhattacharya Apurba , Purohit Vikram C. , Suarez Victor , Tichkule Ritesh , Parmer Gaurang , Rinaldi Frank 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Visible Light‐Induced Highly Selective Transformation of Olefin to Ketone by 2,4,6‐Triphenylpyrylium Cation Encapsulated within Zeolite Y.
Authors: Shiraishi Yasuhiro , Saito Naoya , Hirai Takayuki 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
D‐Phg‐L‐Pro Dipeptide‐Derived Prolinol Ligands for Highly Enantioselective Reformatsky Reactions.
Authors: Shin Eun‐kyoung , Kim Hyun Jung , Kim Yongtai , Kim Yangmee , Park Yong Sun 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Design and Synthesis of Bis(thiourea) Ligands and Their Application in Pd‐Catalyzed Heck and Suzuki Reactions under Aerobic Conditions.
Authors: Chen Wei , Li Rui , Han Bo , Li Bang‐Jing , Chen Ying‐Chun , Wu Yong , Ding Li‐Sheng , Yang Dan 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reductive Mannich‐Type Reaction Using the Composite Reagents of Phosphine and Lewis Acid.
Authors: Kikuchi Satoshi , Kobayashi Takayuki , Hashimoto Yukihiko 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Fluorescent Sensing of Maleate versus Fumarate by a Neutral Cyclohexane Based Thiourea Receptor.
Authors: Costero Ana M. , Colera Manuel , Gavina Pablo , Gil Salvador 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Entry for the Synthesis of N‐Acyl‐N′‐Substituted Guanidines.
Authors: Shinada Tetsuro , Umezawa Taiki , Ando Tsuyoshi , Kozuma Hayato , Ohfune Yasufumi 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Magnesiated Unsaturated Silylated Cyanohydrins as Synthetic Equivalents of Aromatic and Heterocyclic Grignard Reagents Bearing a Ketone or an Aldehyde.
Authors: Liu Ching‐Yuan , Ren Hongjun , Knochel Paul 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Baker′s Yeast‐Mediated Enantioselective Reduction of Substituted Fluorenones.
Authors: Li Feng , Cui Jingnan , Qian Xuhong , Ren Weimin , Wang Xingyong 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Simple Synthesis of Azuleno[1,2‐c]thiophenes (VII) by Reactions of 1‐Acyl‐2‐(bromomethyl)azulenes (IV) with Thioamides.
Authors: Hou J. R. , Wang D. L. , Kimiaki Imafuku 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Gold(I)‐Catalyzed Intramolecular Hydroamination of Alkenyl Carbamates.
Authors: Han Xiaoqing , Widenhoefer Ross A. 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Concise Synthesis of Novel Naphtho[a]carbazoles and Benzo[c]carbazoles.
Authors: Pathak Rakhi , Nhlapo Johanna M. , Govender Sameshnee , Michael Joseph P. , van Otterlo Willem A. L. , de Koning Charles B. 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Aza‐Crown Ether Tethered with Benzothiazole: Synthesis and Optical Spectral Studies.
Authors: Mashraqui Sabir H. , Dhaval Vashi , Subramanian S. , Khan Tabrez B. 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reactions of 5‐Methylsulfinyl‐1‐(4‐nitrophenyl)tetrazole with N‐Nucleophiles.
Authors: Egorova N. G. , Artamonova T. V. , Hrabalek A. , Koldobskii G. I. 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Dipotassium Hydrogen Phosphate Powder Catalyzed Conversion of Dialkyl 2‐(2,5‐Dihydroxyphenyl)‐3‐ (1,1,1‐triphenyl‐λ5‐phosphanylidene)succinates to Alkyl 6‐Hydroxy‐2‐oxo‐2H‐chromen‐4‐carboxylates.
Authors: Souldozi Ali , Ramazani Ali , Noshiranzadeh Nader 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Herbicidal Activities of Fluorine‐Containing 3‐Pyridylmethyl‐2‐phenyliminothiazolidine Derivatives.
Authors: Li Gangyue , Qian Xuhong , Cui Jingnan , Huang Qingchun , Cui Dawei , Zhang Rong , Liu Fengyu 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Solid‐State Induced Heterocyclization under Microwave Irradiation: Synthesis of 2‐Phenyl‐3‐hydroxy‐quinolin‐4(1H)‐one (IV).
Authors: Heravi Majid M. , Oskooie Hossein A. , Bahrami Lila , Ghassemzadeh Mitra 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Antifungal Activity of N‐(Alkyl/Aryl)‐2‐(3‐oxo‐1,4‐benzothiazin‐2‐yl)acetamide.
Authors: Gupta G. , Wagh S. B. 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Sila‐venlafaxine, a Sila‐Analogue of the Serotonin/Noradrenaline Reuptake Inhibitor Venlafaxine: Synthesis, Crystal Structure Analysis, and Pharmacological Characterization.
Authors: Daiss Juergen O. , Burschka Christian , Mills John S. , Montana John G. , Showell Graham A. , Warneck Julie B. H. , Tacke Reinhold 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Facile Stereoselective Synthesis of (2E)‐3‐Silylallylic Alcohols by Hydromagnesiation of 1‐Aryl‐2‐silylacetylenes.
Authors: Cai Mingzhong , Zhou Zhou , Jiang Jianwen 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Concise Sultone Route to Highly Oxygenated 1,10‐seco‐Eudesmanolides — Enantioselective Total Synthesis of the Antileukemic Sesquiterpene Lactones (‐)‐Eriolanin (Ia) and (‐)‐Eriolangin (Ib).
Authors: Merten Joern , Hennig Andre , Schwab Pia , Froehlich Roland , Tokalov Sergey V. , Gutzeit Herwig O. , Metz Peter 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
General Method for Synthesizing Pyranoid Glycals. A New Route to Allal and Gulal Derivatives.
Authors: Boutureira Omar , Rodriguez Miguel Angel , Matheu M. Isabel , Diaz Yolanda , Castillon Sergio 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Malonganenones A—C, Novel Tetraprenylated Alkaloids from the Mozambique Gorgonian Leptogorgia gilchristi.
Authors: Keyzers Robert A. , Gray Christopher A. , Schleyer Michael H. , Whibley Catherine E. , Hendricks Denver T. , Davies‐Coleman Michael T. 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Guanaconetins, New Antitumoral Acetogenins, Mitochondrial Complex I and Tumor Cell Growth Inhibitors
Authors: Cortes Diego , et al. et al. 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Kehokorins A—C, Novel Cytotoxic Dibenzofurans Isolated from the Myxomycete Trichia favoginea var. persimilis.
Authors: Kaniwa Kouken , Ohtsuki Takashi , Yamamoto Yukinori , Ishibashi Masami 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Absolute Stereochemistry and Antitumor Activity of Iejimalides.
Authors: Nozawa Kohei , Tsuda Masashi , Ishiyama Haruaki , Sasaki Takuma , Tsuruo Takashi , Kobayashi Jun'ichi 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Synthesis of Cytotoxic Anhydrophytosphingosine Pachastrissamine (Jaspine B) from D‐Xylose.
Authors: Du Yuguo , Liu Jun , Linhardt Robert J. 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Convenient Synthesis of Xyridin A Metabolite from Xyris indica L.
Authors: Ahmed Hafiz Badar‐ud‐Din , Rama Nasim Hasan , Malana Muhammad Aslam , Qadeer Ghulam 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Transition Metal Complexed Catenanes and Rotaxanes in Motion: Towards Molecular Machines
Authors: Collin Jean‐Paul , Heitz Valerie , Bonnet Sylvestre , Sauvage Jean‐Pierre 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Template‐Controlled Synthesis in the Solid State
Authors: MacGillivray Leonard R. , Papaefstathiou Giannis S. , Friscic Tomislav , Varshney Dushyant B. , Hamilton Tamara D. 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
TNT Equivalence Values of Intentional Explosives and of Solid or Liquid Chemical Condensation Products at Risk of Accidental Explosion
Authors: Mory J. , Branka R. 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Intramolecular 1,3‐Dipolar Cycloreversion — A Key Step in Novel Thermal Isomerizations of Cyclobutane‐di(carbomethoxy)‐triazolines
Authors: Margetic Davor , Jin Chuan‐Ming , Warrener Ronald N. , Butler Douglas N. 
Published: June 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.