bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renal cell carcinoma with multiple bone metastases effectively treated by a combination of tyrosine kinase inhibitor, robot‐assisted partial nephrectomy, and metastasectomy
Authors: Sawada Atsuro , Takeda Masashi , Goto Takayuki , Akamatsu Shusuke , Kobayashi Takashi 
Published: March 2024

Key Clinical MessageMaintaining a disease‐free status for a long time in cases of renal cell carcinoma with multiple bone metastases and repeated recurrences is challenging. What matters most in the multidisciplinary approach is the treatment strategy. Although this is a case where multidisciplinary treatment resulted in long‐term CR during the TKI era, the treatment strategy is still relevant now that treatment options have increased.AbstractRecent advances in medications, such as immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs), have improved metastatic renal cell carcinoma (mRCC) outcomes. We report a case of mRCC with bone metastasis that was successfully treated using a multidisciplinary approach. Here, we present a case of a 56‐year‐old man with left renal cancer and large and painful bone metastases at the 11th thoracic vertebrae (Th11). Therefore, a metastasectomy of Th11 was performed. Systemic treatment with TKI, robot‐assisted partial nephrectomy, and metastasectomy were then administered. No recurrence was observed in >2 years. Long‐term disease‐free survival with the TKI‐era multidisciplinary approach in a patient with mRCC remains significant when considering treatment sequences, especially now that drug treatment options—including ICIs—have increased. Treatment strategy and indication and timing of resection of the primary lesion and metastasectomy should be carefully considered in each case.
Mechanism and Kinetics Guided Design of Catalysts for Functionalized Nitroarenes Hydrogenation
Authors: Yao Chang , Li Wenhua , Ge Xiaohu , Shi Yao , Cao Yueqiang , Chen De , Zhou Xinggui , Duan Xuezhi 
Published: March 2024

AbstractSelective hydrogenation of functionalized nitroarenes to anilines employed with heterogeneous catalysts is a significant process and widely applied in chemical industry. However, designing high‐performance catalysts for these processes remains challenging. Recently, notable advancements have been achieved in synthesis methodologies, characterization techniques, and theoretical calculations, offering opportunities to gain insights into mechanisms. This review summarizes the recent progress in understanding the mechanistic aspects of selective hydrogenation catalysis for functionalized nitroarenes. We initiate by delving into the structure‐performance relationship, with the aim of providing a comprehensive understanding of mechanistic and kinetic details in the selective hydrogenation of functionalized nitroarenes. Subsequently, we introduce various strategies for designing high‐performance catalysts, categorizing them into three key aspects: isolating active sites, synergizing active sites and regulating local environments of active sites. Finally, we conclude with a concise overview of the current state of this field and provide a forward‐looking perspective for future studies, emphasizing the high‐performance design and manipulation of catalysts to achieve precise control over selectivity towards target products.
Effect of resin composition on cure depth, dimensional accuracy, and surface roughness in Al2O3 stereolithographic 3D printing
Authors: McAleer Eoin G. , Alazzawi Mustafa K. , Haber Richard A. , Akdoğan Enver Koray 
Published: March 2024

AbstractThe choice of resin for ceramic stereolithographic 3D printing has a critical impact on printed ceramic preforms. In this study, we focused on the correlation between resin composition and parameters such as cure depth, surface morphology, lateral dimension, apparent layer height, and surface roughness. Special emphasis was placed on the addition of an oligomer and a plasticizing agent to a monomer‐based suspension. Four suspensions were studied: a 100% monomer (ethoxylated trimethylolpropane triacrylate) only suspension (M100), a suspension with 25% by weight plasticizing agent (polyethylene glycol) (PEG25), and two different suspensions with oligomer (urethane methacrylate) added at 25% (O25) and 50% (O50) by weight. Constant energy and printing parameters were used between suspensions. Adding a plasticizing agent (PEG25) was found to increase the cure depth and projected image of the samples, while additional oligomer with both amounts (O25 and O50) resulted in a decrease in the same parameters. The suspensions with oligomer were found to have increased surface roughness measured using the average deviation from the profile height mean line (Ra), with O25 at 13.47 µm and O50 at 11.47 µm. All suspensions had negative values of skewness (Rsk) in the range –0.4 to –1.2. PEG25 had the surface most distinct from a normally distributed surface with an Rsk of –1.12 and a kurtosis (Rku) value of 4.49. The use of the average length of a profile element (RSm) as a layer height estimation tool was explored and it was found that the RSm was within 10 µm of the printed layer height in all suspensions studied except for PEG25. This study highlights the importance of resin composition in ceramic stereolithographic 3D printing. Modulating the inclusion of a plasticizing agent and oligomer in the resin has significant effects on printed sample parameters such as cure depth and surface roughness.
Barrieretechnologien und Automatisierung in der Pharmaherstellung
Authors: Denk Richard 
Published: March 2024

AbstractContainment in der chemischen und pharmazeutischen Industrie dient dem Schutz von Mitarbeitern, Umwelt und Produkten und verhindert Kreuzkontaminationen. Richard Denk, Chair COP Containment DACH ISPE und Senior Consultant Aseptic Processing & Containment bei der Skan, gibt im CITplus‐Interview einen Ausblick auf seinen Vortrag im Rahmen des virtuellen ReinRaumTechnik‐Events “Containment in der Pharma‐ und Chemieindustrie” am 13. März.
Kommunikationstechnologien für Sensoren
Authors: Wiener Michael , Müller Nico 
Published: March 2024

AbstractDie Integration und Vernetzung moderner Technologien wie Single Pair Ethernet, IO‐Link und Sensor‐to‐Cloud‐Kommunikation eröffnet neue Möglichkeiten. Die Machine‐to‐Machine Kommunikation als ein wesentliches Element der Industrie 4.0 gewinnt unter Kosten‐ und Effizienzgesichtspunkten immer mehr an Bedeutung.
Geprüfte H2‐Dichtungswerkstoffe
Authors: Lubos Philipp 
Published: March 2024

AbstractDie Werkstoff‐Familie H2Pro ist für Dichtungsapplikationen entlang der Wasserstoff‐Wertschöpfungskette ausgelegt. Unter den Lösungen befinden sich ein neues Ethylen‐Propylen‐Dien‐Monomer (EPDM) für Hochdruckumgebungen in einem breiten Temperaturbereich sowie ein thermoplastisches Polyurethan (TPU) für sehr niedrige Temperaturen. Einsatzbereiche sind zum Beispiel Ventil‐Anwendungen, Durchflussmesser, Filter und Anschlüsse.
Impact of engineered water in modulating the wettability of oil–brine–rock system for improved oil recovery
Authors: Behera Uma Sankar , Dadhich Raghav , Sangwai Jitendra S. 
Published: March 2024

AbstractLow salinity water injection stands as a progressive method for enhanced oil recovery, representing a current focus of extensive research. Understanding wettability alteration in crude oil is hindered by its intricate nature, posing a challenge for researchers. In order to better understand wettability alteration and underlying phenomena in an oil–brine–rock system, a fundamental study was carried out using pure hydrocarbon (aliphatic: n‐heptane; aromatic: toluene) and crude oil on quartz surface against engineered water consist of monovalent (NaCl) and divalent (MgSO4) salts in various compositions (NaCl:MgSO4: 100:0; NaCl:MgSO4: 0:100; NaCl:MgSO4: 75:25; NaCl:MgSO4: 50:50; NaCl:MgSO4: 25:75). The variables under investigation include temperature (25 to 65°C), pure hydrocarbons (toluene, n‐heptane), crude oil (Indian offshore), and brine (B1 to B5) with concentration (0 to 20,000 ppm). The findings show that when brine solution contains solely NaCl salt at a concentration of 2000 ppm, n‐heptane exhibits a minimum contact angle on quartz plate. Contrarily, toluene exhibits a low contact angle with a brine solution that only contains MgSO4 salt at a concentration of 2000 ppm. The intriguing finding is that when monovalent and divalent salts are equal (NaCl:MgSO4: 50:50) in the brine, crude oil exhibits the smallest contact angle on quartz. Additionally, temperature and contact angle are directly related for all oil types. The optimal brine for achieving the minimum contact angle on quartz surface is (B1)2000 for n‐heptane, (B2)2000 for toluene, and (B4)2000 for crude oil for the current study. The study findings indicate that the alteration in wettability due to brine composition and salinity varies among different oil samples, characterized by purely aliphatic, aromatic, and mixed components, and it depends on the type of salt compositions. Higher salts concentration minimally affects n‐heptane but influences toluene and crude oil contact angles.
Surface Engineering on Zinc Anode for Aqueous Zinc Metal Batteries
Authors: Peng Huili , Ge Wenjing , Ma Xiaojian , Jiang Xiaolei , Zhang Kaiyuan , Yang Jian 
Published: March 2024

AbstractRechargeable aqueous zinc metal batteries (AZMBs) are considered as a potential alternative to lithium‐ion batteries due to their low cost, high safety, and environmental friendliness. However, the Zn anodes in AZMBs face severe challenges, such as dendrite growth, metal corrosion, and hydrogen evolution, all of which are closely related to the Zn/electrolyte interface. This article offers a short review on surface passivation to alleviate the issues on the Zn anodes. The composition and structure of the surface layers significantly influence their functions and then the performance of the Zn anodes. The recent progresses are introduced, according to the chemical components of the passivation layers on the Zn anodes. Moreover, the challenges and prospects of surface passivation in stabilizing Zn anodes are discussed, providing valuable guidance for the development of AZMBs.
A novel 13‐level switched‐capacitor step‐up inverter with reduced component count
Authors: Anand Ravi , Mandal Rajib Kumar 
Published: March 2024

SummaryThis article presents a switched‐capacitor‐based 13‐level inverter that exhibits step‐up property. The suggested converter makes use of a single DC source, 12 switches, three capacitors, and two diodes to accomplish the goal of producing a 13‐level output voltage while simultaneously achieving a boosting factor of six. Notably, inherent voltage balancing is attained for a wide variety of load types without the need of complex control methods or additional circuitry. In addition to this, the paper presents a comprehensive study of the power losses that occur across the different components of the converter. Multiple aspects of a topology's performance are taken into account during a comparison analysis with recent topologies that have a single and double DC sources connected to the input. The investigation incorporates simulations with both inductive and resistive loads. In order to validate that the proposed converter is effective, a prototype is built in the laboratory. The practicality of the suggested topology is shown by the collection of experimental result acquired under different loading situations. These findings include dynamic fluctuations in load and modulation indices.
Fixation of an esophageal stent using a novel re‐openable endoclip for a tracheoesophageal fistula
Authors: Kubota Yo , Nishiyama Ryu , Sasaki Masaya , Sakabe Yuta , Doi Kusutaro , Kitagawa Hiroyuki , Kikuchi Hidehiko , Kusano Chika 
Published: March 2024

AbstractAlthough esophageal stenting is one treatment option as a palliative treatment for tracheoesophageal fistulas, serious complications are associated with stent migration. Some reports have described stent fixation using various devices to prevent stent migration. However, these have yet to be sufficiently examined. We performed esophageal stent fixation using the MANTIS Clip (Boston Scientific), a novel re‐openable endoclip. An 89‐year‐old man developed a tracheoesophageal fistula after radiotherapy for esophageal squamous cell carcinoma. Esophageal stenting was considered because the patient had difficulty with oral intake. However, the patient had a mild stenosis, which suggested stent migration. Therefore, we performed esophageal stent fixation by grasping the mouth side of the stent and the normal mucosa of the esophagus with the MANTIS Clip after placement of the stent. The esophageal stent closed the fistula, and the patient was able to take food orally. Upper gastrointestinal endoscopy performed 3 weeks after stenting showed residual MANTIS Clip and no evidence of stent migration. Esophageal stent fixation with MANTIS clips for tracheoesophageal fistulas may be an option to prevent stent migration.
Differentiating localized autoimmune pancreatitis and pancreatic ductal adenocarcinoma using endoscopic ultrasound images with deep learning
Authors: Nakamura Hitomi , Fukuda Motohisa , Matsuda Akiko , Makino Naohiko , Kimura Hirohito , Ohtaki Yu , Nawa Yoshihito , Oyama Soushi , Suzuki Yuya , Kobayashi Toshikazu , Ishizawa Tetsuya , Kakizaki Yasuharu , Ueno Yoshiyuki 
Published: March 2024

AbstractObjectivesLocalized autoimmune pancreatitis is difficult to differentiate from pancreatic ductal adenocarcinoma on endoscopic ultrasound images. In recent years, deep learning methods have improved the diagnosis of diseases. Hence, we developed a special cross‐validation framework to search for effective methodologies of deep learning in distinguishing autoimmune pancreatitis from pancreatic ductal adenocarcinoma on endoscopic ultrasound images.MethodsData from 24 patients diagnosed with localized autoimmune pancreatitis (8751 images) and 61 patients diagnosed with pancreatic ductal adenocarcinoma (20,584 images) were collected from 2016 to 2022. We applied transfer learning to a convolutional neural network called ResNet152, together with our innovative imaging method contributing to data augmentation and temporal data process. We divided patients into five groups according to different factors for 5‐fold cross‐validation, where the ordered and balanced datasets were created for the performance evaluations.ResultsResNet152 surpassed the endoscopists in all evaluation metrics with almost all datasets. Interestingly, when the dataset is balanced according to the factor of the endoscopists’ diagnostic accuracy, the area under the receiver operating characteristic curve and accuracy were highest at 0.85 and 0.80, respectively.ConclusionsIt is deduced that image features useful for ResNet152 correlate with those used by endoscopists for their diagnoses. This finding may contribute to sample‐efficient dataset preparation to train convolutional neural networks for endoscopic ultrasonography‐imaging diagnosis.
Should Researchers Destroy Audio or Video Recordings?
Authors: Resnik David B. , Antes Alison , Mozersky Jessica 
Published: March 2024

ABSTRACTIt is a common practice in qualitative research to transcribe audio or video files from interviews or focus groups and then destroy the files at some future time, usually after validating the transcript or concluding the research. We argue that it is time to rethink this practice and that retention of original qualitative data—including audio and video recordings—should be the default stance in most cases.
The synergistic effects of a leaf mixture on decomposition change with a period of terrestrial exposure prior to immersion in a stream
Authors: Abelho Manuela , Descals Enrique 
Published: March 2024

AbstractThe effect of mixing litter on decomposition has received considerable attention in terrestrial and aquatic (but rarely in both) ecosystems, with a striking lack of consensus in the obtained results. We studied the decomposition of a mixture of poplar and alder in three terrestrial: aquatic exposures to determine (1) if the effect of mixing litter on mass loss, associated decomposers (fungal biomass, sporulation rates, and richness), and detritivores (abundance, biomass, and richness of invertebrate shredders) differs between the stream (fully aquatic exposure) and when litter is exposed to a period of terrestrial exposure prior to immersion and (2) the effect of the mixture across exposure scenarios. The effect of the mixture was additive on mass loss and synergistic on decomposers and detritivores across exposure scenarios. Within scenarios, mass loss and decomposers showed synergistic effects only in the fully aquatic exposure, detritivores showed synergistic effects only when the period of terrestrial was shorter than the period of aquatic exposure, and when the period of terrestrial was equal to the period of aquatic exposure the effect of the mixture was additive on mass loss, decomposers, and detritivores. The species‐specific effects also differed among exposure scenarios. Alder affected poplar only when there was a period of terrestrial exposure, with increased sporulation rates and fungal richness in exposure 25:75, and increased mass loss in exposure 50:50. Poplar affected alder only under fully aquatic exposure, with increased mass loss. In conclusion, the synergistic effects of the mixture changed with a period of terrestrial exposure prior to immersion. These results provide a cross‐boundary perspective on the effect of mixing litter, showing a legacy effect of exposure to terrestrial decomposition on the fate of plant litter in aquatic ecosystems and highlighting the importance of also assessing the effect of mixing litter on the associated biota and not only on mass loss.
Let's get high: Cladogenesis in freshwater crabs (Decapoda: Potamonautidae: Potamonautes) supports the mountain gradient speciation hypothesis in the Cape Fold and Drakensberg Mountains, South Africa
Authors: Daniels Savel R. , Peer Nasreen , Myburgh Angus Macgregor , Barnes Aaron , Klaus Sebastian 
Published: March 2024

AbstractDuring the present study, the evolutionary relationship within a clade of mountain clade of freshwater crabs (Potamonautes) was examined using mtDNA sequence data for species from the Cape Fold Mountain (CFM) and Great Escarpment (Drakensberg Mountain range). We undertook phylogenetic analyses, divergence time estimation, and an ancestral area reconstruction to explore the period of cladogenesis and understand the biogeographic history in this high‐altitude clade. Furthermore, we applied four species delimitation methods using ASAP, bPTP, bGMYC, and STACEY on the latter clade. Bayesian phylogenetic analyses retrieved a monophyletic freshwater crab clade comprised of two major sister clades, one comprised of the Cape Fold (clade A) and two comprised of Drakensberg Mountains (clade B) species. Divergence time estimation indicated that the two clades underwent Mio/Pliocene cladogenesis. Within the CFM clade (A), P. amathole (Amathola Mountains) was sister to P. parvispina (Cederberg and Kouebokkeveld Mountains) and the latter species were sister to P. parvicorpus (Cape Peninsula, Jonkershoek, and Helderberg Mountains) sister to P. tuerkayi (Overberg Mountains) and P. brincki (Hottentots Holland Mountains). Within the Drakensberg Mountain clade (B), we observed in situ diversification. Specimens from the southcentral Drakensberg Mountains (Dargle Forest, Injasuti, Karkloof, and Impendle) represent a new undescribed lineage Potamonautes sp. nov. 1. The second clade from the northern Drakensberg, representing P. clarus, was sister to a central Drakensberg Mountain clade that comprised P. depressus that was in turn sister to P. baziya from the Eastern Cape Province. The application of species delimitation methods generally overestimated the number of species. The biogeographic analyses indicated that the Eastern Cape Province is the most likely ancestral range area. Ecological niche modelling of representative species in clades A (Cape Fold Mountains) and B (Drakensberg Mountains) demonstrated that temperature and rainfall were the major abiotic drivers that differentiated the two clades. Our data favours the mountain gradient speciation hypothesis.
Frequency of natural regulatory T cells specific for factor VIII in the peripheral blood of healthy donors
Authors: Menier Catherine , Meunier Sylvain , Porcheddu Valeria , Romano Laurène , Correia Evelyne , Busato Florence , Tost Jorg , Maillère Bernard 
Published: March 2024

AbstractTolerance to self‐proteins involves multiple mechanisms, including conventional CD4+ T‐cell (Tconv) deletion in the thymus and the recruitment of natural regulatory T cells (nTregs). The significant incidence of autoantibodies specific for the blood coagulation factor VIII (FVIII) in healthy donors illustrates that tolerance to self‐proteins is not always complete. In contrast to FVIII‐specific Tconvs, FVIII‐specific nTregs have never been revealed and characterized. To determine the frequency of FVIII‐specific Tregs in human peripheral blood, we assessed the specificity of in vitro expanded Tregs by the membrane expression of the CD137 activation marker. Amplified Tregs maintain high levels of FOXP3 expression and exhibit almost complete demethylation of the FOXP3 Treg‐specific demethylated region. The cells retained FOXP3 expression after long‐term culture in vitro, strongly suggesting that FVIII‐specific Tregs are derived from the thymus. From eleven healthy donors, we estimated the frequencies of FVIII‐specific Tregs at 0.17 cells per million, which is about 10‐fold lower than the frequency of FVIII‐specific CD4+ T cells we previously published. Our results shed light on the mechanisms of FVIII tolerance by a renewed approach that could be extended to other self‐ or non‐self‐antigens.
Unlocking the Power of Acyl Fluorides: A Comprehensive Guide to Synthesis and Properties
Authors: Bonnefoy Clémence , Gallego Adrien , Delobel Clément , Raynal Betty , Decourt Maxime , Chefdeville Emmanuel , Hanquet Gilles , Panossian Armen , Leroux Frédéric R. , Toulgoat Fabien , Billard Thierry 
Published: March 2024

AbstractAcyl fluorides have emerged as versatile reagents in various synthetic endeavors, offering a range of advantages over their counterparts, acyl chlorides. This study delves into the properties and reactivity of acyl fluorides, particularly their reaction with amines and alcohols, to elucidate their distinct characteristics. We also introduce a facile and practical synthesis of acyl fluorides from a stable solution of CF3O− salt. Additionally, we establish an efficient one‐pot process for the direct preparation of amides or esters from corresponding acids and amines or alcohols, showcasing the remarkable efficiency of acyl fluorides in these transformations.
Recent Advances of 2‐Nitroglycals as Powerful Glycosyl Donors
Authors: Li Xinxin , Deng Lei , Wang Liming , Zhang Qingju 
Published: March 2024

Abstract2‐Nitroglycals are important synthons for biological active 2‐aminoglycosides, glycoconjugates and natural products synthesis. Herein, we summarized the recent advances of 2‐nitroglycals including its synthetic methods and its applications. Using 2‐nitroglycals, 2‐aminoglycosides, nitro‐polyol derivatives, sugar‐furan derivatives, sugar‐pyrrole molecules, 2,3‐diaminoglycosides and 2‐amino‐1,3‐dithioglycosides were obtained via Michael–type addition, retro‐Henry‐type reaction, C1/C3‐Ferrier rearrangement and [3+2] N‐heterocyclic addition. Most of these conversions are achieved via mild organo‐catalysis glycosylation methods.