bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collagen‐polyurethane‐dextran hydrogels enhance wound healing by inhibiting inflammation and promoting collagen fibrillogenesis
Authors: Aguayo‐Morales Hilda , Cobos‐Puc Luis E. , Lopez‐Badillo Claudia M. , Oyervides‐Muñoz Ernesto , Ramírez‐García Gonzalo , Claudio‐Rizo Jesús A. 
Published: April 2024

AbstractDiabetic foot ulcers are a serious complication of uncontrolled diabetes, emphasizing the need to develop wound healing strategies that are not only effective but also biocompatible, biodegradable, and safe. We aimed to create biomatrices composed of semi‐interpenetrated polymer networks of collagen, polyurethane, and dextran, to enhance the wound healing process. The hydrogels were extensively characterized by various analytical techniques, including analysis of their structure, crystallinity, thermal properties, gelation process, reticulation, degradation, cell proliferation, and healing properties, among others. Semi‐interpenetrated hydrogels containing dextran at levels of 10%, 20%, and 30% exhibited porous interconnections between collagen fibers and entrapped dextran granules, with a remarkable crosslinking index of up to 94% promoted by hydrogen bonds. These hydrogels showed significant improvements in mechanical properties, swelling, and resistance to proteolytic and hydrolytic degradation. After 24 h, there was a significant increase in the viability of several cell types, including RAW 264.7 cells, human peripheral blood mononuclear cells, and dermal fibroblasts. In addition, these hydrogels demonstrated an increased release of interleukin‐10 and transforming growth factor‐beta1 while inhibiting the release of monocyte chemotactic protein‐1 and tumor necrosis factor‐alpha after 72 h. Furthermore, these hydrogels accelerated the wound healing process in diabetic rats after topical application. Notably, the biomaterial with 20% dextran (D20) facilitated wound closure in only 21 days. These results highlight the potential of the D20 hydrogel, which exhibits physicochemical and biological properties that enhance wound healing by inhibiting inflammation and fibrillogenesis while remaining safe for application to the skin.
Modifying electronic and optical properties of violet phosphorus through variable fluorine coverage
Authors: Wang Suen , Liu Xiaoyu , Zhang Yang , Li Shasha , Bo Xiangyan , Wei Lujun , Niu Wei , Wu Hong , Pu Yong , Li Feng 
Published: April 2024

AbstractWe present a comprehensive investigation of the electronic properties of fluorinated monolayer violet phosphorus using first‐principles calculations. Our results reveal a strong dependence of the electronic properties on the different fluorine coverages of fluorination. As the fluorine coverage increases, monolayer violet phosphorus undergoes a significant transition from a wide direct bandgap semiconductor to a narrow indirect bandgap semiconductor. Moreover, both semi‐fluorinated and fully fluorinated monolayer violet phosphorus exhibit advantageous semiconducting characteristics, with a tunable bandgap of 0.50 ~ 1.04 eV under biaxial strain ranging from −6% to 6%. Notably, the fully fluorinated monolayer violet phosphorus demonstrates a higher coefficient of light absorption within the visible range. Therefore, our findings highlight the tunability of monolayer violet phosphorus properties through the absorption of various fluorine coverages, providing valuable insights for the design and development of novel semiconductor devices based on this material.
Hospitalizations and transgender patients in the United States
Authors: Khanijow Keshav , Wright Scott , Hedian Helene , Harris Che 
Published: April 2024

AbstractIt is known that transgender people experience health inequalities. Disparities in hospital outcomes impacting transgender individuals have been inadequately explored. We conducted this retrospective cohort study using the National Inpatient Sample (01/2018–12/2019) to compare in‐hospital mortality and utilization variables between cisgender and transgender individuals using regression analyses. Approximately two‐thirds of hospitalizations for transgender patients (n = 10,245) were for psychiatric diagnoses. Compared to cisgender patients, there were no significant differences in adjusted means differences (aMD) in length of stay (LOS) (aMD = −0.29; p = .16) or total charges (aMD = −$486; p = .56). An additional 4870 transgender patients were admitted for medical diagnoses. Transgender and cisgender individuals had similar adjusted odds ratios (aOR) for in‐hospital mortality (aOR = 0.96; p = .88) and total hospital charges (aMD = −$3118; p = .21). However, transgender individuals had longer LOS (aMD = +0.46 days; confidence interval [CI]: 0.15–0.90; p = .04). When comparing mortality and resource utilization between cisgender and transgender individuals, differences were negligible.
Esophageal food bolus impaction in pediatric age
Authors: Quitadamo Paolo , Pascarella Antonia , Gragnaniello Piergiorgio , Isoldi Sara , Bucci Cristina , Turco Rossella , Puoti Maria Giovanna , Furio Silvia , Caldore Mariano , Di Nardo Giovanni 
Published: April 2024

AbstractObjectivesEsophageal food impaction (EFI) is the sudden onset of dysphagia that occurs when a food bolus becomes lodged in the esophagus, requiring endoscopic removal. Scientific data on the prevalence and causes of EFI in children is lacking. The aim of this study was to provide further insights into EFI episodes in children.MethodsWe have prospectively enrolled all children admitted for a first episode of EFI between March 2018 and March 2023. A fluoroscopic contrast study was performed in all patients to confirm the boluses and assess their position. Boluses were extracted by esophagogastroduodenoscopies, and esophageal biopsies were routinely obtained for histologic evaluation.ResultsOver the study period, 41 children were admitted for a first episode of food impaction. Drooling was the most commonly reported symptom. Half children experiencing a first episode of food bolus were diagnosed with EoE (20/41, 48.8%). Almost a fourth of the episodes subtended a different condition, such as esophageal anastomotic, peptic or congenital strictures, stricturing caustic esophagitis, esophageal duplication, and achalasia. In the last fourth of patients the cause of EFI was not identified and thus probably related to quick eating and inadequate chewing of food.DiscussionOur study represents the largest known series of pediatric patients evaluated for food bolus impaction. Our main finding is the high frequency of EoE, which accounts for a half of EFI episodes in pediatric age, especially in older children. This finding highlights the importance of obtaining esophageal biopsies after the endoscopic bolus removal in children with EFI to provide a complete diagnostic evaluation.
Enhancing salt tolerance and crop growth in agricultural systems: the impact of magnetized‐ionized water irrigation on soil properties, microbial communities, and cotton growth
Authors: Lin Shudong , Wang Quanjiu , Zhao Xue , Gu Yunna , Wei Kai , Luo Pengcheng , Deng Mingjiang 
Published: April 2024

AbstractBACKGROUNDThe development of agricultural practices requires an understanding of the improvement of salt tolerance and crop growth in agricultural systems through magnetized‐ionized water irrigation.METHODThis study examined the impacts of fresh water (F), brackish water (B), magnetized‐ionized fresh water (MIF), and magnetized‐ionized brackish water (MIB) on soil properties and the growth of cotton seedlings through microbial analysis during the cotton seedling period.RESULTSThe results revealed that magnetized‐ionized water irrigation improved soil water retention and promoted salt leaching. In comparison with F irrigation, plant height, leaf area index (LAI), dry matter accumulation (DM), and chlorophyll content (SPAD) levels increased by 3.61%, 4.07%, 5.76%, and 1.33%, respectively, under MIF irrigation. Similarly, when compared with B irrigation, LAI, DM, and SPAD increased by 5.13%, 6.12%, and 3.12% under MIB irrigation. Magnetized‐ionized water irrigation also led to a notable rise in the relative abundance of beneficial soil bacterial communities, particularly Pseudomonas and Azoarcus, as well as fungal communities like Trichoderma, while reducing the prevalence of pathogenic fungi, such as Lasionectria, Gibberella, and Alternaria. Notably, this irrigation approach induced alterations in soil properties, and partial least squares path modeling revealed significant links between soil properties and both cotton growth and fungal community structure (with path coefficients of −0.884 and 0.693, respectively).CONCLUSIONThis study elucidated the distinct effects of soil properties and growth indices on cotton yield during the seedling period, providing a crucial scientific foundation for enhancing future agricultural production through the use of magnetized‐ionized water irrigation. © 2024 Society of Chemical Industry.
Updates in global oncology: Advancements and future directions
Authors: Jackman Julia M. , Yibrehu Betel , Doyle Alex , Alatise Olusegun Isaac , Wuraola Funmilola Olanike , Olasehinde Olalekan , Peter Kingham T. 
Published: April 2024

AbstractGlobally, cancer is the second leading cause of death, and low‐ and middle‐income countries bear most of the disease burden. While cancer is increasingly recognized as a major global health issue, more work remains. Understanding the status of global cancer care will shape the next steps in ensuring equitable global access to cancer care. This article highlights ongoing initiatives in global oncology and the next steps in advancing the field.
Congenital disorders of glycosylation with multiorgan disruption and immune dysregulation caused by compound heterozygous variants in MAN2B2
Authors: Fan Shiqi , Wu Huanhuan , Wang Rongrong , Chen Qian , Zhang Xue 
Published: April 2024

AbstractBackgroundCongenital disorders of glycosylation (CDG) are a type of inborn error of metabolism (IEM) resulting from defects in glycan synthesis or failed attachment of glycans to proteins or lipids. One rare type of CDG is caused by homozygous or compound heterozygous loss‐of‐function variants in mannosidase alpha class 2B member 2 (MAN2B2). To date, only two cases of MAN2B2‐CDG have been reported worldwide.MethodsTrio whole‐exome sequencing (Trio‐WES) was conducted to screen for candidate variants. N‐glycan profiles were measured by liquid chromatography–tandem mass spectrometry (LC–MS/MS). MAN2B2 expression was evaluated by western blotting. MX dynamin like GTPase 1 (MX1) function was estimated via Thogoto virus (THOV) minireplicon assay.ResultsTrio‐WES identified compound heterozygous MAN2B2 (hg19, NM_015274.1) variants (c.384G>T; c.926T>A) in a CDG patient. This patient exhibited metabolic abnormalities, symptoms of digestive tract dysfunction, infection, dehydration, and seizures. Novel immune dysregulation characterized by abnormal lymphocytes and immunoglobulin was observed. The MAN2B2 protein level was not affected, while LC–MS/MS showed obvious disruption of N‐glycans and N‐linked glycoproteins.ConclusionWe described a CDG patient with novel phenotypes and disruptive N‐glycan profiling caused by compound heterozygous MAN2B2 variants (c.384G>T; c.926T>A). Our findings broadened both the genetic and clinical spectra of CDG.
In vivo T2 measurements of the fetal brain using single‐shot fast spin echo sequences
Authors: Bhattacharya Suryava , Price Anthony N. , Uus Alena , Sousa Helena S. , Marenzana Massimo , Colford Kathleen , Murkin Peter , Lee Maggie , Cordero‐Grande Lucilio , Teixeira Rui Pedro A. G. , Malik Shaihan J. , Deprez Maria 
Published: April 2024

AbstractPurposeWe propose a quantitative framework for motion‐corrected T2 fetal brain measurements in vivo and validate the single‐shot fast spin echo (SS‐FSE) sequence to perform these measurements.MethodsStacks of two‐dimensional SS‐FSE slices are acquired with different echo times (TE) and motion‐corrected with slice‐to‐volume reconstruction (SVR). The quantitative T2 maps are obtained by a fit to a dictionary of simulated signals. The sequence is selected using simulated experiments on a numerical phantom and validated on a physical phantom scanned on a 1.5T system. In vivo quantitative T2 maps are obtained for five fetuses with gestational ages (GA) 21–35 weeks on the same 1.5T system.ResultsThe simulated experiments suggested that a TE of 400 ms combined with the clinically utilized TEs of 80 and 180 ms were most suitable for T2 measurements in the fetal brain. The validation on the physical phantom confirmed that the SS‐FSE T2 measurements match the gold standard multi‐echo spin echo measurements. We measured average T2s of around 200 and 280 ms in the fetal brain grey and white matter, respectively. This was slightly higher than fetal T2* and the neonatal T2 obtained from previous studies.ConclusionThe motion‐corrected SS‐FSE acquisitions with varying TEs offer a promising practical framework for quantitative T2 measurements of the moving fetus.
Spatiotemporal encoding MRI in a portable low‐field system
Authors: Qiu Yueqi , Dai Ke , Zhong Sijie , Chen Suen , Wang Changyue , Chen Hao , Frydman Lucio , Zhang Zhiyong 
Published: April 2024

AbstractPurposeDemonstrate the potential of spatiotemporal encoding (SPEN) MRI to deliver largely undistorted 2D, 3D, and diffusion weighted images on a 110 mT portable system.MethodsSPEN's quadratic phase modulation was used to subsample the low‐bandwidth dimension of echo planar acquisitions, delivering alias‐free images with an enhanced immunity to image distortions in a laboratory‐built, low‐field, portable MRI system lacking multiple receivers.ResultsHealthy brain images with different SPEN time‐bandwidth products and subsampling factors were collected. These compared favorably to EPI acquisitions including topup corrections. Robust 3D and diffusion weighted SPEN images of diagnostic value were demonstrated, with 2.5 mm isotropic resolutions achieved in 3 min scans. This performance took advantage of the low specific absorption rate and relative long TEs associated with low‐field MRI.ConclusionSPEN MRI provides a robust and advantageous fast acquisition approach to obtain faithful 3D images and DWI data in low‐cost, portable, low‐field systems without parallel acceleration.
Can pelvic floor muscle function before surgery determine the outcome of surgical treatment of stress urinary incontinence in women?
Authors: Szymański Jacek K. , Krawczyk Agata , Starzec‐Proserpio Małgorzata , Raczkiewicz Dorota , Kukulski Piotr , Jakiel Grzegorz 
Published: April 2024

AbstractAimThe study aimed to determine whether pelvic floor muscle (PFM) function before surgery may correlate with the success of surgical interventions for treating stress urinary incontinence (SUI). Our hypothesis was that addressing identified variables in preoperative rehabilitation could potentially improve surgical outcomes.MethodsThis prospective observational study was conducted at a single center and enrolled women qualified to mid‐urethral tape insertion for SUI between 2020 and 2022. Digital palpation and manometry (Peritron™ 9300 V) were used to evaluate PFM function. The following parameters were acquired: vaginal resting pressure, vaginal pressure during maximal voluntary contraction (MVC), the area under the curve during a 10‐second MVC, moreover the ability to perform correct PFM contraction, reflexive PFM contraction during cough and relaxation were assessed. All measurements were performed before the surgical treatment and during follow‐up assessments at 1, 3, and 6 months postoperatively. The primary endpoint of the study was defined as objective cure, characterized by a negative cough stress test (CST), along with a subjective assessment based on the Urogenital Distress Inventory‐6 (UDI‐6) and Incontinence Impact Questionnaire‐7 (IIQ‐7).ResultsThe study involved 57 eligible female participants, all of whom completed the 6‐month follow‐up. Objective cure was observed in 75.44% of cases, while subjective cure was reported in 33%. There was no association between PFM parameters and surgical outcomes.ConclusionThe success of surgical treatment of SUI 6 months postsurgery is not related to preoperative pelvic floor muscle function.
Guideline for evaluating the effects of psychotropic drugs on motor vehicle driving performance in Japan: A tiered approach for the assessment of clinically meaningful driving impairment
Authors: Nakabayashi Tetsuo , Iwamoto Kunihiro , Yamaguchi Akiko , Konishi Yuki , Saji Momoe , Yoshimura Reiji , Kanemoto Kousuke , Aoki Hirofumi , Ando Masahiko , Ozaki Norio 
Published: April 2024

AbstractIn December 2022, the Ministry of Health, Labour and Welfare (MHLW) of Japan issued and implemented the guideline for evaluating the effects of psychotropic drugs on motor vehicle driving performance. This guideline recommends the use of a tiered approach to assess clinically meaningful driving impairment. It is noted that adverse events cannot be solely explained by pharmacokinetics, as the onset and duration of these events vary. Among these adverse events, those affecting alertness, such as drowsiness caused by psychotropic drugs on driving performance, are more frequently observed during initial treatment stages and dose escalation. Hence, when evaluating the effects of psychotropic drugs on driving performance, it becomes crucial to assess the persistence of clinically meaningful impairment. Therefore, the MHLW guideline, developed by the authors, emphasizes the need to assess the temporal profile of adverse events affecting driving in all clinical trials. Additionally, the guideline states that when conducting driving studies, the timing of multiple dosing should consider not only the pharmacokinetics of the investigational drug but also its tolerance.
Comparative Study of Catalytic Activity of Recyclable Au/Fe3O4 Microparticles for Reduction Of 2,4‐Dinitrophenol and Anionic, Cationic Azo Dyes.
Authors: Batsukh Ikhbayar , Khishigjargal Tegshjargal , Dembereldorj Uuriintuya , Sambuu Munkhtsetseg , Ganbold Erdene‐Ochir , Norov Erdene 
Published: April 2024

AbstractWe synthesized Au/Fe3O4 microparticles. Initially, citrate‐capped Fe3O4 micro‐sized particles were synthesized by the co‐precipitation method with an excess amount of trisodium citrate. Gold ions were reduced on the surface of citrate‐capped Fe3O4 and grew as gold sub‐microparticles with an average diameter of 210 nm on the surface. The characteristic SPR peak of gold nanoparticles on the surface of Fe3O4 was detected at 584 nm, whereas the absorption in the near‐infrared region was increased. SEM images has proved that the synthesized Au/Fe3O4 composite microparticles has an average diameter of 1.7 micrometers. The results of XRD patterns proved the existence of both crystal phases of Fe3O4 and Au particles. To investigate the catalytic activity, the reaction rate constant of reduction of 2,4‐dinitrophenol (2,4‐DNP) and degradation of Congo red (CR), and methylene blue (MB) with NaBH4 in the presence of Au/Fe3O4 catalyst was monitored by UV‐Vis spectroscopy. The initial reaction rate constant calculated from the change in characteristic peak absorptions of 2,4‐dinitrophenol was 3.97×10−3 s−1, while the reaction rate constants for the degradation of CR and MB were 9.72×10−3 s−1 and 14.25×10−3 s−1 respectively. After 5 cycles, Au/Fe3O4 microparticles preserved 99 % of the reaction rate constant, exhibiting considerable recycling efficiency in the reduction of nitro groups.
Preparation and characterization of halloysite nanotube‐silica/silicone rubber composites: Effect of HNTs on mechanical and thermal properties
Authors: Wang Fanghui , Shen Xiaomei , Wang Qingfu , Zhu Hong 
Published: April 2024

AbstractA series of halloysite nanotube‐silica (HNTs‐SiO2) nanocomposite fillers were prepared by in‐situ assembly, and a reinforced SiO2/SR composite was obtained by filling them into silicone rubber (SR). The morphology and structural characterization of HNTs‐SiO2 and HNTs‐SiO2/SR and the properties of the HNTs‐SiO2/SR were studied. As a result, the small particle size SiO2 was firmly anchored onto the HNTs surface, and the obtained HNTs‐SiO2 nanofillers were uniformly dispersed in SR. At a 30 phr fixed filler loading, the weakest filler network and the best filler dispersion were obtained when HNTs content in HNTs‐SiO2 was 5%. This resulted in a maximum tensile strength obtained of 6.2 MPa, 1.55 times that of SiO2/SR with the same filler loading, and a maximum elongation at break of 418%, 1.67 times that of the SiO2/SR with the same filler loading, and at the same time the tearing strength and hardness are also improved. Furthermore, the silicone rubber also showed improved thermal stability, with an initial degradation temperature increase of 30°C under a nitrogen atmosphere.Highlights
HNTs–SiO2 nanocomposites were successfully prepared by the self‐assembly method and used as fillers in SR as a new type of reinforcing material.
The 1D HNTs act as a barrier to prevent SiO2 aggregation and improved fillers dispersion.
The elongation at break and tensile strength of 5% HNTs‐SiO2/SR are 67% and 55% higher than those of SiO2/SR, respectively.
The silicone rubber also showed improved thermal stability.
Surgical treatment may improve depressive and hysterical traits in temporal lobe epilepsy with hippocampal sclerosis: Study using the Minnesota Multiphasic Personality Inventory
Authors: Otabe Hiroyuki , Taniguchi Go , Iijima Keiya , Iwasaki Masaki 
Published: April 2024

AbstractAimThe influence of surgeries on psychiatric symptoms and personality traits is not well known in patients with intractable temporal lobe epilepsy (TLE). We investigated changes in personality traits with respect to postoperative seizure outcomes, etiology, side of surgery, and sex differences.MethodsClinical information was retrospectively collected for 44 patients whose Minnesota Multiphasic Personality Inventory (MMPI) was examined before and 1 year after surgical treatment for drug‐resistant TLE. Postoperative changes in MMPI T‐scores were analyzed using a paired t‐test. Participants were divided into two groups based on postoperative seizure outcome, the presence or absence of hippocampal sclerosis (HS) as the etiology, side of surgery, and sex differences. The effect of these clinical factors on postoperative changes in MMPI T‐scores was evaluated using analysis of covariance (P‐values < 0.05).ResultsThe hypochondria (Hs) scale decreased significantly in all patients (p = 0.022). The postoperative seizure‐free group had a significant decrease in the depression (D) scale (p = 0.037). The HS group had significant decreases in the D scale and the hysteria (Hy) scale (p = 0.016 and 0.004, respectively), and a significant increase in the masculinity‐femininity (Mf) scale (p = 0.009). No significant differences existed between the sides of surgery or sex.ConclusionDepressive traits were improved in patients with postoperative seizure freedom. Depressive and hysterical traits were improved in patients with HS, which may be attributed to a reduction in anxiety and fear associated with aura. Most personality traits are not significantly changed or exacerbated by surgical treatment of TLE.