bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐Lived Palladium Catalysts for CO/Vinyl Arene Polyketones Synthesis: A Solution to Deactivation Problems
Authors: Durand Jérôme , Zangrando Ennio , Stener Mauro , Fronzoni Giovanna , Carfagna Carla , Binotti Barbara , Kamer Paul C. J. , Müller Christian , Caporali Maria , van Leeuwen Piet W. N. M. , Vogt Dieter , Milani Barbara 
Published: June 2006

AbstractA series of cationic palladium complexes of general formula [Pd(Me)(MeCN)(N–N)][PF6] (N–N = (phen) 1 a, 4,7‐dichloro‐1,10‐phenanthroline (4,7‐Cl2‐phen) 2 a, 4,7‐diphenyl‐1,10‐phenanthroline (4,7‐Ph2‐phen) 3 a, 4‐methyl‐1,10‐phenanthroline (4‐Me‐phen) 4 a, 4,7‐dimethyl‐1,10‐phenanthroline (4,7‐Me2‐phen) 5 a, 5,5,6,6‐tetrafluoro‐5,6‐dihydro‐1,10‐phenanthroline (F4‐phen) 6 a, containing different substituted phenanthroline ligands, have been prepared from the corresponding neutral chloro derivatives [Pd(Me)(Cl)(N–N)], (1 b–6 b). The X‐ray crystal structure of [Pd(Cl)2(4,7‐Cl2‐phen)] (2 b′) was determined. DFT calculations show that the electron density on the metal is tuned by the substituents on the ligands. The catalytic behavior of complexes 1 a–6 a in the CO/styrene and CO/p‐Me‐styrene copolymerizations was studied in detail, showing that the generated catalysts are active for at least 90 h, yielding copolymers of high molecular weight. A firm correlation between the electron density on palladium on the one hand and the catalytic activity of the complexes and the molecular weight and the stereochemistry of the polyketones synthesized on the other hand has been established: the catalyst containing the F4‐phen is thus far the most active among those tested, yielding the syndiotactic CO/styrene copolymer with a stereoregularity of 96 % (uu triad) and with an Mw value of 1 000 000.
Significantly Accelerated Direct Electron‐Transfer Kinetics of Hemoglobin in a C60‐MWCNT Nanocomposite Film
Authors: Zhang Hua , Fan Louzhen , Yang Shihe 
Published: June 2006

AbstractThe direct electrochemistry of hemoglobin (Hb) was studied in a novel all‐carbon nanocomposite film of C60‐MWCNT (MWCNT=multiple‐walled carbon nanotube) and compared with that in bare MWCNT film. The heterogeneous electron‐transfer rate constant ks of Hb/C60‐MWCNT was determined to be 0.39 s−1, which is more than one order of magnitude greater than that of Hb/MWCNT (0.03 s−1). The significantly accelerated electron‐transfer kinetics are attributed to the mediator role played by C60, which is finely dispersed on the MWCNT surfaces. The excellent stability of Hb/C60‐MWCNT was established and its potential application towards the electrocatalytic reduction of O2 was demonstrated.
Characterising the Electronic Structure of Ionic Liquids: An Examination of the 1‐Butyl‐3‐Methylimidazolium Chloride Ion Pair
Authors: Hunt Patricia A. , Kirchner Barbara , Welton Tom 
Published: June 2006

AbstractIn this paper we analyse the electronic properties of gas‐phase 1‐butyl‐3‐methylimidazolium Cl ion pairs, [C4C1im]Cl, in order to deepen our understanding of ionic liquids in general. Examination of charge densities, natural bond orbitals (NBO), and delocalised molecular orbitals computed at the B3LYP and MP2/6‐31++G(d,p) levels have enabled us to explain a number of experimental phenomena: the relative acidity of different sites on the imidazolium ring, variations in hydrogen‐bond donor and acceptor abilities, the apparent contradiction of the hydrogen‐bond‐donor parameters for different types of solute, the low probability of finding a Cl− anion at the rear of the imidazolium ring and the expansion of the imidazolium ring in the presence of a strong hydrogen‐bond acceptor. The unreactive but coordinating environment and large electrochemical window have also been accounted for, as has the strong electron‐donating character of the carbon atoms to the rear of the ring in associated imidazolylidenes. The electronic structure of the [C4C1im]+ cation is best described by a C4C5 double bond at the rear, and a delocalised three‐centre 4 e− component across the front (N1‐C2‐N3) of the imidazolium ring; delocalisation between these regions is also significant. Hydrogen‐bond formation is driven by Coulombic stabilisation, which compensates for an associated destabilisation of the electronic part of the system. Interactions are dominated by a large positive charge at C2 and the build up of π‐electron density above and below the ring, particularly that associated with the double bond between C4 and C5. The NBO partial charges have been computed and compared with those used in a number of classical simulations.
Ruthenation of Duplex and Single‐Stranded d(CGGCCG) by Organometallic Anticancer Complexes
Authors: Liu Hong‐Ke , Wang Fuyi , Parkinson John A. , Bella Juraj , Sadler Peter J. 
Published: June 2006

AbstractWe have studied the interaction of the organometallic anticancer ruthenium(II) complexes [(η6‐p‐cymene)Ru(en)Cl][PF6] (1) and [(η6‐biphenyl)Ru(en)Cl][PF6] (2) (en=ethylenediamine) with the single‐stranded (ss) DNA hexamer d(CGGCCG) (I) and the duplex d(CGGCCG)2 (II) by HPLC, ESI‐MS, and one‐ and two‐dimensional 1H and 15N NMR spectroscopy. For ss‐DNA, all three G's are readily ruthenated with [(η6‐arene)Ru(en)]2+, but for duplex DNA there is preferential ruthenation of G3 and G6, and no binding to G2 was detected. For monoruthenated duplexes, N7 ruthenation of G is accompanied by strong hydrogen bonding between G‐O6 and en‐NH for the p‐cymene adducts. Intercalation of the non‐coordinated phenyl ring between G3 and C4 or G6 and C5 was detected in the biphenyl adducts of mono‐ and diruthenated duplexes, together with weakening of the G‐O6⋅⋅⋅NH‐en hydrogen bonding. The arene ligand plays a major role in distorting the duplex either through steric interactions (p‐cymene) or through intercalation (biphenyl).
Carbonic Anhydrase Activators. Activation of Isozymes I, II, IV, VA, VII, and XIV withL‐ andD‐Histidine and Crystallographic Analysis of Their Adducts with Isoform II: Engineering Proton‐Transfer Processes within the Active Site of an Enzyme
Authors: Temperini Claudia , Scozzafava Andrea , Vullo Daniela , Supuran Claudiu T. 
Published: June 2006

AbstractActivation of six human carbonic anhydrases (CA, EC 4.2.1.1), that is, hCA I, II, IV, VA, VII, and XIV, withl‐andd‐histidine was investigated through kinetics and by X‐ray crystallography.l‐His was a potent activator of isozymes I, VA, VII, and XIV, and a weaker activator of hCA II and IV.d‐His showed good hCA I, VA, and VII activation properties, being a moderate activator of hCA XIV and a weak activator of hCA II and IV. The structures as determined by X‐ray crystallography of the hCA II–l‐His/d‐His adducts showed the activators to be anchored at the entrance of the active site, contributing to extended networks of hydrogen bonds with amino acid residues/water molecules present in the cavity, explaining their different potency and interaction patterns with various isozymes. The residues involved inl‐His recognition were His64, Asn67, Gln92, whereas three water molecules connected the activator to the zinc‐bound hydroxide. Only the imidazole moiety ofl‐His interacted with these amino acids. For thed‐His adduct, the residues involved in recognition of the activator were Trp5, His64, and Pro201, whereas two water molecules connected the zinc‐bound water to the activator. Only the COOH and NH2moieties ofd‐His participated in hydrogen bonds with these residues. This is the first study showing different binding modes of stereoisomeric activators within the hCA II active site, with consequences for overall proton‐transfer processes (rate‐determining for the catalytic cycle). The study also points out differences of activation efficiency between various isozymes with structurally related activators, convenient for designing alternative proton‐transfer pathways, useful both for a better understanding of the catalytic mechanism and for obtaining pharmacologically useful derivatives, for example, for the management of Alzheimer's disease.
Catalytic Ethylene Polymerisation in Carbon Dioxide as a Reaction Medium with Soluble Nickel(II) Catalysts
Authors: Bastero Amaia , Franciò Giancarlo , Leitner Walter , Mecking Stefan 
Published: June 2006

AbstractA series of neutral NiII–salicylaldiminato complexes substituted with perfluorooctyl‐ and trifluoromethyl groups, [Ni{κ2‐N,O‐6‐C(H)NAr‐2,4‐R′2C6H2O}(Me)(pyridine)] (6 a: Ar=2,6‐{4‐(F17C8)C6H4}2C6H3, R′=I; 6 b: Ar=2,6‐{4‐(F3C)C6H4}2C6H3, R′=I; 6 c: Ar=2,6‐{3,5‐(F3C)2C6H3}2C6H3, R′=3,5‐(F3C)2C6H3; 6 d: Ar=2,6‐{4‐(F17C8)C6H4}2C6H3, R′=3,5‐(F3C)2C6H3; 6 e: Ar=2,6‐{3,5‐(F3C)2C6H3}2C6H3, R′=I) were studied as catalyst precursors for ethylene polymerisation in supercritical CO2. Catalyst precursors 6 a and 6 c, which are soluble in scCO2, afford the highest polymer yields, corresponding to 2×103 turnovers. Semicrystalline polyethylene (Mn typically 104 g mol−1) is obtained with variable degrees of branching (11 to 24 branches per 1000 carbon atoms, predominantly Me branches) and crystallinities (54 to 21 %), depending on the substitution pattern of the catalyst.
Specific Vectorial Immobilization of Oligonucleotide‐Modified Yeast Cytochrome c on Carbon Nanotubes
Authors: Heering Hendrik A. , Williams Keith A. , de Vries Simon , Dekker Cees 
Published: June 2006

AbstractIso‐1‐cytochrome c from the yeast Saccharomyces cerevisiae (YCC) contains a surface cysteine residue, Cys102, that is located opposite to the lysine‐rich side containing the exposed heme edge, which is the docking site for enzymes. Site‐specific vectorial immobilization of YCC via Cys102 on single‐walled carbon nanotubes (SWNT) thus provides a selective interface between nanoscopic electronic devices and complex enzymes. We have achieved this by modification of Cys102 with an oligonucleotide (dT18). Atomic force microscopy, fluorescence imaging, and cyclic voltammetry show the specific adsorption of YCC, modified with dT18, on the SWNT sidewall with retention of its native properties. Pretreatment of the SWNT with Triton‐X405 blocks the nonspecific binding of untreated YCC but does not interfere with binding of the oligonucleotide‐modified YCC.
Surface Composition of Materials Used as Catalysts for Methanol Steam Reforming: A Theoretical Study
Authors: Lim Kok Hwa , Moskaleva Lyudmila V. , Rösch Notker 
Published: June 2006

AbstractPdZn (1:1) alloy is assumed to be the active component of a promising catalyst for methanol steam reforming. Using density functional calculations on periodic supercell slab models, followed by atomistic thermodynamics modeling, we study the chemical composition of the surfaces PdZn(111) and, as a reference, Cu(111) in contact with water and hydrogen at conditions relevant to methanol steam reforming. For the two surfaces, we determine similar maximum adsorption energies for the dissociative adsorption of H2, O2, and the molecular adsorption of H2O. These reactions are calculated to be exothermic by about −40, −320, and −20 kJ mol−1, respectively. Using a thermodynamic analysis based on theoretically predicted adsorption energies and vibrational frequencies, we determine the most favorable surface compositions for given pressure windows. However, surface energy plots alone cannot provide quantitative information on individual coverages in a system of coupled adsorption reactions. To overcome this limitation, we employ a kinetic model, from which equilibrium surface coverages of H, O, OH, and H2O are derived. We also discuss the sensitivity of our results and the ensuing conclusions with regard to the model surfaces employed and the inaccuracies of our computational method. Our kinetic model predicts surfaces of both materials, PdZn and Cu, to be essentially adsorbate‐free already from very low values of the partial pressure of H2. The model surfaces PdZn(111) and Cu(111) are predicted to be free of water‐related adsorbates for a partial H2 pressure greater than 10−8 and 10−5 atm, respectively.
Prediction of upper aerodigestive tract cancer by slide‐based cytometry
Authors: Gerstner Andreas O. H. , Thiele Alexander , Tárnok Attila , Tannapfel Andrea , Weber Anette , Bootz Friedrich 
Published: June 2006

AbstractAim:To evaluate slide‐based cytometry in screening for and following up of carcinoma of the upper aerodigestive tract using swabs for a minimal‐invasive approach.Methods:Laser scanning cytometry (LSC) was used for multiparametric analysis of cells stained for cytokeratin and DNA to determine the DNA‐index (DI) of the tumor cells. Histograms with 0.95 < DI < 1.05 and 1.9 < DI < 2.1 were defined as DNA euploid and any other DI as DNA aneuploid. After subsequent HE‐staining, single cells were relocalized in order to document morphology. Conventional cytology was also performed on a subset of the slides. Routine histopathology of parallel biopsies served as gold standard in all cases.Results:115 swabs from 109 patients were obtained from the entire upper aerodigestive tract. 16 swabs were classified as insufficient for LSC. In the remaining 99 specimens, 1 benign lesion was misclassified as malignant, while 61 of the 75 malignant lesions were correctly identified. This corresponds to predictive values of 98.4% and 62.2% for the detection of malignant and benign samples by LSC.Conclusion:This pilot study demonstrates the validity of LSC screening for the identification of tumor malignancy in the upper aerodigestive tract from swab collected cytological material. © 2005 International Society for Analytical Cytology
A Route to Multi‐Clusters Containing Half‐Sandwich Rh and Ir Complexes of Chelating 1,2‐Dicarba‐closo‐dodecaborane(12)‐1,2‐dithiolate Ligands
Authors: Wang Jian‐Qiang , Ren Chun‐Xia , Jin Guo‐Xin 
Published: June 2006

AbstractReaction of the 16‐electron half‐sandwich rhodium and iridium complexes [Cp*M{S2C2(B10H10)}] [M = Rh (1a), Ir (1b)] with multidentate ligands (L) such as 5,10,15,20‐tetra(4‐pyridyl)porphyrin) (H2TPyP), 2,4,6‐tri(4‐pyridyl)‐1,3,5‐triazine (tpt), and 4,4′‐azopyridine, gave the corresponding multi‐cluster complexes [Cp*MS2C2(B10H10)]n(L) [M = Rh, Ir; n = 4, L = H2TPyP (2); 3, L = tpt (3); 2, L = 4,4′‐azopyridine (4), N,N′‐bis(4‐pyridinylmethylene)biphenyl‐4,4′‐diamine (5), pyrazine, (6), 2,5‐di(4‐pyridyl)‐1,3,4‐oxadiazole (7), 1,2‐di(4‐pyridyl)ethylene) (8), diisonicotinic acid 1,4‐phenylene diester (9), 4,4′‐bipyridine (10)]. The X‐ray structure of 2a reveals that an H2TPyP unit bridges four [Cp*RhS2C2(B10H10)] fragments to form a tetranuclear [Cp*RhS2C2(B10H10)]4(H2TPyP) complex and the [Cp*RhS2C2(B10H10)] units adopt a tail‐to‐tail contact mode, rather than a head‐to‐tail mode, in spite of the large steric repulsion between the two carborane ligands. In complex 3a, three [Cp*RhS2C2(B10H10)] units are symmetrically arranged around the periphery of one tpt core, thus forming a “bowl‐shaped” structure. In 4a, 5a, 6a, 8b, and 9b, two [Cp*RhS2C2(B10H10)] fragments take a trans conformation around the linear or pseudo‐linear pyridyl‐based ligand core, while in 7a they are in a cis conformation. All new complexes 2–10 were characterized by 1H and 11B NMR spectroscopy, and X‐ray structural analyses are reported for complexes 2a, 3a, 4a, 5a, 6a, 7a, 8b, and 9b. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Cationic Brønsted Acids for the Preparation of SnIV Salts: Synthesis and Characterisation of [Ph3Sn(OEt2)][H2N{B(C6F5)3}2],[Sn(NMe2)3(HNMe2)2][B(C6F5)4] and [Me3Sn(HNMe2)2][B(C6F5)4]
Authors: Sarazin Yann , Coles Simon J. , Hughes David L. , Hursthouse Michael B. , Bochmann Manfred 
Published: June 2006

AbstractPh3SnN(SiMe3)2 (1) was prepared in good yields by reaction of [{NaN(SiMe3)2}2·THF] (2) with Ph3SnF. Treatment of 1 with [H(OEt2)2][H2N{B(C6F5)3}2] (4) in dichloromethane afforded the stannylium cation [Ph3Sn(OEt2)][H2N{B(C6F5)3}2] (5), which was characterised by 1H, 13C{1H}, 11B, 19F and 119Sn NMR spectroscopy. The reaction of Sn(NMe2)4 with [Ph2MeNH][B(C6F5)4] (3) gave the amidotin(IV) compound [Sn(NMe2)3(HNMe2)2][B(C6F5)4] (6) which proved very stable towards ligand substitution and resisted treatment with Et2O, THF, TMEDA and pyrazine. Two new Brønsted acid salts [H(NMe2H)2][B(C6F5)4] (7) and [(C4H4N2)H·OEt2][H2N{B(C6F5)3}2] (8) were synthesised. The reaction of 7 with Sn(NMe2)4 in Et2O allowed the preparation of 6 in a much improved yield (83 %). The treatment of 7 with Me3SnN(SiMe3)2 in Et2O yielded [Me3Sn(HNMe2)2][B(C6F5)4] (9) nearly quantitatively. Compounds 1, 2, 6, 8 and 9 were characterised by single‐crystal X‐ray diffraction analyses; 6 is the first example of a structurally characterised amidotin(IV)cation.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Novel Catalytic Tandem Isomerisation/Cyclisation Reaction of α‐Methallyloxy Carboxylic Acids
Authors: Chaminade Xavier , Coulombel Lydie , Olivero Sandra , Dunach Elisabet 
Published: June 2006

AbstractA new tandem isomerisation/cyclisation of α‐methallyloxy carboxylic acids leading to substituted 1,3‐dioxolan‐4‐ones in 60–70 % yields was catalysed by Cu(OTf)2 or Al(OTf)3. Extension to the synthesis of oxathiolanones and oxathianones is also described. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Highly Enantio‐ and Diastereoselective One‐Pot Reactions in Aqueous Media: Combined Asymmetric Rh‐Catalyzed Conjugate Addition/Metal‐Mediated Allylation
Authors: Källström Sara , Jagt Richard B. C. , Sillanpää Reijo , Feringa Ben L. , Minnaard Adriaan J. , Leino Reko 
Published: June 2006

Abstract1,3‐Disubstituted, enantiopure cyclohexanols have been prepared in very high diastereoselectivities and good yields by a concise one‐pot method combining the enantioselective rhodium‐catalyzed conjugate addition of arylboronic acids with indium‐mediated allylation into a highly efficient one‐pot reaction in aqueous media. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
One‐Pot Synthesis of (±)‐Crispine A and Its C‐Ring‐Substituted Analogs
Authors: Meyer Nino , Opatz Till 
Published: June 2006

AbstractA straightforward access to crispine A and C‐ring‐substituted analogs by 1,4‐addition of a deprotonated α‐amino nitrile to α,β‐unsaturated carbonyl compounds is described. If the reduction step is omitted, substituted 5,6‐dihydropyrrolo[2,1‐a]isoquinolines can be obtained. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Amperometric Glucose Biosensor Based on Rhodium Dioxide‐Modified Carbon Ink
Authors: Kotzian Petr , Brázdilová Petra , Řezková Soňa , Kalcher Kurt , Vytřas Karel 
Published: June 2006

AbstractAn amperometric method for the determination of glucose using a screen printed carbon electrode is reported. The electrode material was bulk modified with rhodium dioxide and the enzyme glucose oxidase immobilized in a Nafion‐film on the electrode surface and investigated for its ability to serve as a detector of glucose in flow injection analysis. The sensor exhibited a linear increase of the amperometric signal with the concentration of glucose in the range of 1–250 mg L−1 with a detection limit (evaluated as 3σ) of 0.2 mg L−1 under optimized flow rate of 0.4 mL min−1 in 0.1 M phosphate buffer (pH 7.5) carrier. At the potential applied (−0.2 V vs. Ag/AgCl), interferences from redox species present in the sample matrix were negligible. The biosensor reported here retained its activity for more than 40 injections or 4 months of storage at 6 °C. The RSD was determined as 1.8% for a glucose concentration of 25 mg L−1 (n=5) with a typical response time of about 28 s.
Anodic Stripping Voltammetric Determination of Aurothiomalate in Urine Using a Screen‐Printed Carbon Electrode
Authors: Bergamini Márcio F. , Boldrin Zanoni Maria Valnice 
Published: June 2006

AbstractThis work describes an electroanalytical method for determining gold(I) thiomalate, aurothiomalate, widely used for treatment of reumatoid arthiritis, using a screen‐printed carbon electrode (SPCE). Aurothiomalate (AuTM) was determined indirectly at the same electrode by accumulating it first at −1.5 V vs. printed carbon. At this potential in the adsorbed state, the AuTM is reduced to Au(0), which is then oxidized at two steps at −0.22 V and +0.54 V on SPCE. Using optimized conditions of 60 s deposition time, −1.5 V (vs. printed carbon) accumulation potential, 100 mV s−1 scan rate, linear calibration graphs can be obtained by monitoring the peak at +0.54 V for AuTM in HCl 0.1 mol L−1 from 1.43×10−6 to 1.55×10−4 mol L−1. A limit of detection obtained was 6.50×10−7 mol L−1, and the relative standard deviation from five measurements of 3.0×10−5 mol L−1 AuTM is 4.5%. The method was successfully applied for AuTM determination in human urine sample.
Peptide Modified Electrodes as Electrochemical Metal Ion Sensors
Authors: Chow Edith , Gooding J. Justin 
Published: June 2006

AbstractSensors for the detection of metal ions are of considerable importance for enabling the monitoring of environmental samples for metal ion contamination directly in the field. This review outlines the use of peptides and amino acids as the recognition element of electrochemical sensors for metal ion detection. Initially the complexation of metals by peptides is discussed followed by the immobilization of peptides on electrode surfaces. Subsequently, the application of peptide modified electrodes for detecting metals is reviewed and finally challenges and future prospects are outlined.
Large‐scale Pyrosequencing of synthetic DNA: A comparison with results from Sanger dideoxy sequencing
Authors: Gharizadeh Baback , Herman Zelek S. , Eason Robert G. , Jejelowo Olufisayo , Pourmand Nader 
Published: June 2006

AbstractPyrosequencing is a relatively recent method for sequencing short stretches of DNA. Because both Pyrosequencing and Sanger dideoxy sequencing were recently used to characterize and validate DNA molecular barcodes in a large yeast gene‐deletion project, a meta‐analysis of those data allow an excellent and timely opportunity for evaluating Pyrosequencing against the current gold standard, Sanger dideoxy sequencing. Starting with yeast genomic DNA, parallel PCR amplification methods were used to prepared 4747 short barcode‐containing constructs from 6000 Saccharomyces cerevisiae gene‐deletion strains. Pyrosequencing was optimized for average read lengths of 25–30 bases, which included in each case a 20‐mer barcode sequence. Results were compared with sequence data obtained by the standard Sanger dideoxy chain termination method. In most cases, sequences obtained by Pyrosequencing and Sanger dideoxy sequencing were of comparable accuracy, and the overall rate of failure was similar. The DNA in the barcodes is derived from synthetic oligonucleotide sequences that were inserted into yeast‐deletion‐strain genomic DNA by homologous recombination and represents the most significant amount of DNA from a synthetic source that has been sequenced to date. Although more automation and quality control measures are needed, Pyrosequencing was shown to be a fast and convenient method for determining short stretches of DNA sequence.
Perphenylcarbamoylated β‐cyclodextrin bonded‐silica particles as chiral stationary phase for enantioseparation by pressure‐assisted capillary electrochromatography
Authors: Lin Bo , Shi Zhi‐Guo , Zhang Hui‐Juan , Ng Siu‐Choon , Feng Yu‐Qi 
Published: June 2006

AbstractPerphenylcarbamoylated β‐cyclodextrin bonded‐silica particles (5 μm) were packed into 75‐μm fused‐silica capillaries, and used for the enantiomer separation of neutral and basic solutes by pressure‐assisted capillary electrochromatography. Triethylammonium acetate and phosphate buffer were employed as the BGEs. A cathodic EOF was observed with these two BGEs. Seven chiral analytes were successfully resolved into their enantiomers under optimized conditions, and five of them could be baseline‐separated within 12 min due to their high electrophoretic mobility. Better results were achieved with phosphate buffer as the BGE. The effects of organic content and pH on the enantioseparation were also investigated.