bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic analysis of PALB2 gene WD40 domain in canine mammary tumour patients
Authors: Çıldır Özge Şebnem , Özmen Özge , Kul Selim , Rişvanlı Ali , Özalp Gözde , Sabuncu Ahmet , Kul Oğuz 
Published: March 2024

AbstractBackgroundDNA repair mechanisms are essential for tumorigenesis and disruption of HR mechanism is an important predisposing factor of human breast cancers (BC). PALB2 is an important part of the HR. There are similarities between canine mammary tumours (CMT) and BCs. As its human counterpart, PALB2 mutations could be a predisposing factor of CMT.ObjectivesIn this study, we aimed to investigate the impacts of PALB2 variants on tumorigenesis and canine mammary tumor (CMT) malignancy.MethodsWe performed Sanger sequencing to detect germline mutations in the WD40 domain of the canine PALB2 gene in CMT patients. We conducted in silico analysis to investigate the variants, and compared the germline PALB2 mutations in humans that cause breast cancer (BC) with the variants detected in dogs with CMT.ResultsWe identified an intronic (c.3096+8C>G) variant, two exonic (p.A1050V and p.R1354R) variants, and a 3′ UTR variant (c.4071T>C). Of these, p.R1354R and c.4071T>C novel variants were identified for the first time in this study. We found that the p.A1050V mutation had a significant effect. However, we could not determine sufficient similarity due to the differences in nucleotide/amino acid sequences between two species. Nonetheless, possible variants of human sequences in the exact location as their dog counterparts are associated with several cancer types, implying that the variants could be crucial for tumorigenesis in dogs. Our results did not show any effect of the variants on tumor malignancy.ConclusionsThe current project is the first study investigating the relationship between the PALB2 gene WD40 domain and CMTs. Our findings will contribute to a better understanding of the pathogenic mechanism of the PALB2 gene in CMTs. In humans, variant positions in canines have been linked to cancer‐related phenotypes such as familial BC, endometrial tumor, and hereditary cancer predisposition syndrome. The results of bioinformatics analyses should be investigated through functional tests or case‐control studies.
In vitro anti‐Trichomonas gallinae effects of Ziziphus vulgaris L. and Camellia sinensis (L.) Kuntze extracts
Authors: Rahimi Behnam , Malekifard Farnaz , Esmaeilnejad Bijan 
Published: March 2024

AbstractBackgroundTrichomonas gallinae is a parasite that causes canker and severe loss and death, especially in young pigeons. Metronidazole (MTZ) is the recommended drug for treating avian trichomoniasis. Due to drug resistance, non‐chemical alternatives, such as medicinal plant extracts, are also considered possible therapies for this disease.ObjectivesThis study compares the antitrichomonal effects of MTZ with extracts of Camellia sinensis and Ziziphus vulgaris on T. gallinae in vitro.MethodsSamples of T. gallinae were taken from infected pigeons. Multi‐well plates with different concentrations (5, 10, 25, 50 and 100 µg/mL) of plant extracts were used for the in vitro study.ResultsThe minimum inhibitory concentration (MIC) of C. sinensis extract was 25 µg/mL over 24 h, compared to 50 µg/mL for MTZ. The MIC value of the Z. vulgaris extracts was 50 µg/mL.ConclusionsThe results suggest that the extracts of Z. vulgaris and C. sinensis, as potential natural agents, could have anti‐avian trichomoniasis properties. This study also shows that MTZ, C. sinensis and Z. vulgaris are equally effective in preventing the growth of T. gallinae trophozoites in the culture.
Successful management of ventricular bigeminy using lidocaine in a horse anaesthetised for emergency laparotomy
Authors: Dupont Julien , Caudron Isabelle , Loublier Clemence , Serteyn Didier , Sandersen Charlotte 
Published: March 2024

AbstractA 13‐year‐old mare was referred to the Equine Hospital of the University of Liege for colic, 1 week after foaling and was submitted to emergency laparotomy. During anaesthesia, the horse developed ventricular bigeminy that did not compromise haemodynamic stability. Lidocaine (two intravenous [iv] boluses of 1 mg/kg, followed by iv infusion of 1–2 mg/kg/h) effectively terminated the arrhythmia and the animal recovered uneventfully. Although cardiac arrhythmias associated with gastrointestinal disorders are mostly attributed to endotoxaemia, cardiac workup performed postoperatively should not be overlooked. The mare was discharged 23 days after surgery.
Phase Behaviour of Colloidal Platelet–Depletant Mixtures
Authors: Lekkerkerker Henk N. W. , Tuinier Remco , Vis Mark 
Published: March 2024

AbstractColloidal platelets are encountered in a wide range of systems in nature and technology. Examples are hydroxides , smectiteclays and exfoliated inorganic nanosheets. Suspensions of these platelets have been found to exhibit liquid crystal ordering, including gibbsite [1–4], nickel hydroxide [5], layered double hydroxides [6, 7], nontronite [8–10], beidellite [11, 12], fluorohectorite [13, 14], solid phosphatoantimonate acid [15, 16], zirconium phosphate [17–19], niobate [20, 21] and titanate [22].
Trust, risk perception, and intention to use autonomous vehicles: an interdisciplinary bibliometric review
Authors: Naiseh Mohammad , Clark Jediah , Akarsu Tugra , Hanoch Yaniv , Brito Mario , Wald Mike , Webster Thomas , Shukla Paurav 
Published: March 2024

AbstractAutonomous vehicles (AV) offer promising benefits to society in terms of safety, environmental impact and increased mobility. However, acute challenges persist with any novel technology, inlcuding the perceived risks and trust underlying public acceptance. While research examining the current state of AV public perceptions and future challenges related to both societal and individual barriers to trust and risk perceptions is emerging, it is highly fragmented across disciplines. To address this research gap, by using the Web of Science database, our study undertakes a bibliometric and performance analysis to identify the conceptual and intellectual structures of trust and risk narratives within the AV research field by investigating engineering, social sciences, marketing, and business and infrastructure domains to offer an interdisciplinary approach. Our analysis provides an overview of the key research area across the search categories of ‘trust’ and ‘risk’. Our results show three main clusters with regard to trust and risk, namely, behavioural aspects of AV interaction; uptake and acceptance; and modelling human–automation interaction. The synthesis of the literature allows a better understanding of the public perception of AV and its historical conception and development. It further offers a robust model of public perception in AV, outlining the key themes found in the literature and, in turn, offers critical directions for future research.
Manipulation order optimization in industrial pick-and-place operations: application to textile and leather industry
Authors: Martínez-Peral Francisco José , Migallón Héctor , Borrell-Méndez Jorge , Martínez-Rach Miguel , Pérez-Vidal Carlos 
Published: March 2024

AbstractThis work addresses the problem of the development of a robotic system for the picking of parts cut by a CNC machine and the optimization of the sequencing of this picking process. An automated parts collection system is optimized to reduce the time required to perform the task of both picking and the subsequent classification by the type of part. The automated picking system, which is located at the end of a cutting machine, uses a robot equipped with an additional axis to expand its working space. Therefore, in this proposal, the industrial equipment necessary to automate this process is designed and the process to be optimized is computationally modeled. In particular, three discrete optimization algorithms are analyzed, with different evolution strategies and operators, but all of them are free of specific configuration parameters. The whole process is shown in this research, from the design of the procedure to the design of the tool, the algorithm selection, and elements validation. Finally, the first steps towards its industrial implementation are presented, and the hypothesis behind this project is validated.
Portal venous contrast enhancement ratio of the adrenal glands and spleen as prognostic marker of mortality in patients with acute mesenteric ischemia
Authors: Pfister Felix , Mehdorn Matthias , Schwartner Christoph , Seehofer Daniel , Tautenhahn Hans-Michael , Struck Manuel Florian , Denecke Timm , Meyer Hans-Jonas 
Published: March 2024

Abstract
Purpose
Contrast enhancement of the adrenal gland defined by computed tomography (CT) was previously analyzed as a prognostic factor for critically ill patients in various diseases. However, no study investigated this quantitative parameter in patients with acute mesenteric ischemia. Therefore, the aim of this study was to evaluate the prognostic value of the contrast enhancement of the adrenal glands in patients with clinically suspected AMI.

Methods
All patients with clinically suspected AMI were retrospectively assessed between 2016 and 2020. All patients underwent surgical exploration after CT imaging. Overall, 134 patients (52 female patients, 38.8%) with a mean age of 69.2 ± 12.4 years were included into the present analysis. For all patients, the preoperative CT was used to calculate the contrast media enhancement of the adrenal glands and the spleen.

Results
A total of 27 patients (18.5%) died within the first 24 h and over the following 30-day 94 patients (68.6%) died. There were statistically significant differences regarding the mean values for adrenal-to-spleen ratio for 24-h mortality (p = 0.001) and 30-day mortality (p = 0.004), whereas the radiodensity of the inferior vena cava and the radiodensity of the spleen was statistically significant between survivors and non-survivors after 30 days (p = 0.037 and p = 0.028, respectively). In Cox regression analysis, mean adrenal radiodensity was associated with 24-h mortality (HR 1.09, 95% CI 1.02–1.16, p = 0.01) but not with 30-day mortality (HR 1.03, 95% CI 0.99–1.07, p = 0.13).

Conclusion
The contrast media enhancement of the adrenal gland is associated with the 24-h and 30-day mortality in patients with AMI. However, the prognostic relevance for translation into clinical routine needs to be validated in other cohorts.

Graphical abstract
Numerical and experimental investigations on the vibration behavior of a high-speed planetary gearbox
Authors: Schweigert D. , Morhard B. , Oberneder F. , Pointner-Gabriel L. , Otto M. , Stahl K. 
Published: March 2024

AbstractIncreasing the speed of the electric motor can significantly improve the power density of the powertrain of EVs (Electric Vehicles), resulting in a smaller size and thus weight and cost advantages. Achieving acceptable NVH behavior becomes more difficult at higher speeds, partly because the excitation frequencies of the gears cover a wider frequency range and therefore higher natural frequencies can also be directly excited. In the Speed4E joint research project, a high-speed electromechanical powertrain was developed, manufactured, and tested to investigate the main challenges on the NVH- and efficiency-behavior of high-speed powertrains. The high-speed design of the Speed4E drivetrain results in maximum electric motor speeds of up to 50,000 rpm, combined with a torque of up to 45 Nm at the transmission input shafts. This study presents the experimental results on the vibration behavior of the high-speed planetary gearbox, a comparison with the corresponding results of a highly efficient calculation method of the gearbox vibration excitation, and the theoretical background of the calculation method is presented. The results indicate the potential to improve the vibration behavior of high-speed drives in EVs and provide a deep understanding of the challenges associated with high speeds.
A two-step species distribution modeling to disentangle the effect of habitat and bioclimatic covariates on Psacothea hilaris, a potentially invasive species
Authors: Ruzzier Enrico , Lupi Daniela , Tirozzi Pietro , Dondina Olivia , Orioli Valerio , Jucker Costanza , Bani Luciano 
Published: March 2024

AbstractIntegrating host plants in distribution modeling of phytophagous species and disentangling the effect of habitat and bioclimatic variables are key aspects to produce reliable predictions when the aim is to identify suitable areas outside species’ native range. To this aim, we implemented a framework of Species Distribution Model aimed at predicting potential suitable areas of establishment for the beetle Psacothea hilaris across the world. Since habitat (including host plants) and bioclimatic variables affect species distribution according to processes acting at different geographical scales, we modeled these variables separately. For the species native range, we fitted a habitat (HSM) and a bioclimatic (BSM) suitability model calibrated on a local and a large scale, respectively; the overall suitability map was obtained as the spatial product of HSM and BSM projection maps. ROC, TSS and Cohen’s Kappa obtained in validation confirmed a good predictive performance of modeling framework. Within HSM, host plants played a substantial effect on species presence probability, while among bioclimatic variables, precipitation of the warmer quarter and isothermality were the most important. Native HSM and BSM models were used to realize an overall suitability map at world scale. At global scale, many areas resulted suitable for habitat, some for bioclimate, and few for both conditions; indeed, if the species would not be able to modify its bioclimatic niche, it might not be considered a major invasive species. However, the high rate of range expansion documented for P. hilaris in Northern Italy, a poorly suitable bioclimatic area, suggests a plasticity of the species that requires increasing the level of attention to its invasive potential.
How does an economic shock affect environmental attitudes, preferences and issue importance? Evidence from Switzerland
Authors: Rudolph Lukas , Gomm Sarah 
Published: March 2024

AbstractHow do economic shocks affect pressure by the mass public for pro-environmental political action? If democratic systems are to develop and sustain ambitious environmental policy over several decades, this question is important to answer. Theoretically, we argue to look beyond changes in attitudes such as environmental concern, and trace whether and how citizen's policy preferences, and the political importance they attach to environment-related issues change when experiencing a deterioration of their personal economic situation. Empirically, we draw on high-quality population-representative panel survey data for an affluent country, Switzerland, combining tailored survey measures for quasi-random Corona-related employment and income losses, nuanced measures of environmental attitudes and policy preferences, and recently developed measures for issue importance. We neither find a decline of environmental policy support among economically affected individuals compared to the rest of the population (a population wide drop, however), nor lower importance given to environment related relative to economic issues in voting decisions. While this suggests that politicians need not fear electoral losses when pursuing environmental policies in times of economic crisis, we note that the severe extent of the Covid-induced recession, coupled with a rapid recovery, is peculiar to this economic crisis and warrants further research regarding the generalizability of our findings to economic shocks of longer duration.
Formulating a quality model for cloud-native software architectures: conceptual and methodological considerations
Authors: Lichtenthäler Robin , Wirtz Guido 
Published: March 2024

AbstractInterest in cloud computing is steadily increasing and the range of offerings is evolving due to continuous technological innovation. Hence, cloud-native has been established as a term for building applications in a way that maximally exploits benefits of modern cloud computing concepts. However, cloud-native as a topic is broad and the variety in cloud computing technologies is large. Thus, we identify a need in supporting developers and software architects who want to benefit from cloud-native concepts. We provide this support in the form of a quality model for cloud-native software architectures that explains how architectural characteristics impact different quality aspects. Our focus is on the design time and the aim is that architectural models of applications can be evaluated according to cloud-native characteristics and corresponding quality aspects. In this work we present our approach for formulating and validating the quality model for cloud-native software architectures as well as its current state. This presentation is based on previous work, especially a recently conducted validation survey that focused on the impacts of architectural characteristics on quality aspects. The new contribution of this work is the integrated presentation of our approach in a larger context of conceptual and methodological considerations. Further, revision of the quality model based on a repeated literature search for architectural measures is presented. We provide a more detailed look on the quality model, explaining exemplary product factors and their relevance within the topic of cloud-native. Our results provide a qualitative overview of characteristics associated with cloud native software architectures and lay the foundation for quantitative quality evaluations based on architectural models of applications.
Fourier Transform Thermoreflectance Method Under Front-Heat Front-Detect Configuration
Authors: Baba Takahiro , Baba Tetsuya , Mori Takao 
Published: March 2024

AbstractThe thermoreflectance method, which can measure thermal diffusivity in the cross-plane direction of thin films, mainly has two possible configurations; rear-heat front-detect (RF) and front-heat front-detect (FF) configuration. FF configuration is applicable to a wide variety of thin films including thin films deposited on opaque substrates, but this configuration has some problems in determination of the thermal diffusivity. One of the main problems is the effect of the penetration of pump beam and probe beam in thin film, which affects the initial temperature distribution near the sample’s surface after pulse heating. Several studies have tried to analyze the effect but there have been no practical analytical solutions which can solve this problem in FF configuration. In this paper, we propose a new analytical solution which considers the penetration of pump beam and probe beam into thin film, and by applying Fourier expansion analysis which we developed in a previous study to thermoreflectance signals, we have determined the thermal diffusivity of thin film in the thermoreflectance method under FF configuration. We measured platinum thin films with different thickness under both FF and RF configuration and obtained consistent thermal diffusivity values from both configurations.
Novel Internet Support for Neck-Specific Rehabilitation Improves Work-Related Outcomes to the Same Extent as Extensive Visits to a Physiotherapy Clinic in Individuals with Chronic Whiplash-Associated Disorders: A Prospective Randomised Study
Authors: Peolsson Anneli , Nilsing Strid Emma , Peterson Gunnel 
Published: March 2024

AbstractPurposeTo address the current lack of information about work-related factors for individuals with whiplash-associated disorders (WAD) we investigated the effectiveness of 3 months of neck-specific rehabilitation with internet support in combination with four physiotherapy visits (NSEIT) compared to the same exercises performed twice a week (24 times) at a physiotherapy clinic (NSE).MethodsThis is a prospective, multicentre, randomised controlled trial regarding secondary outcomes of work-related factors in 140 individuals with chronic moderate/severe WAD with 3- and 15-month follow-up.ResultsThere were no group differences between NSE and NSEIT in the Work Ability Scale or work subscales of the Neck Disability Index, Whiplash Disability Questionnaire or Fear Avoidance Beliefs Questionnaire (FABQ-work). Both groups improved in all work-related outcome measures, except for FABQ-work after the 3-month intervention and results were maintained at the 15-month follow-up. Conclusions: Despite fewer physiotherapy visits for the NSEIT group, there were no group differences between NSEIT and NSE, with improvements in most work-related measures maintained at the 15-month follow-up. The results of the present study are promising for those with remaining work ability problems after a whiplash injury.Protocol registered before data collection started: clinicaltrials.gov NCT03022812.
Explicit optical solitons of a perturbed Biswas–Milovic equation having parabolic-law nonlinearity and spatio-temporal dispersion
Authors: Cinar Melih 
Published: March 2024

AbstractThis paper deals with a new variant of the Biswas–Milovic equation, referred to as the perturbed Biswas–Milovic equation with parabolic-law nonlinearity in spatio-temporal dispersion. To our best knowledge, the considered equation which models the pulse propagation in optical fiber is studied for the first time, and the abundant optical solitons are successfully obtained utilizing the auxiliary equation method. Utilizing a wave transformation technique on the considered Biswas–Milovic equation, and by distinguishing its real and imaginary components, we have been able to restructure the considered equation into a set of nonlinear ordinary differential equations. The solutions for these ordinary differential equations, suggested by the auxiliary equation method, include certain undetermined parameters. These solutions are then incorporated into the nonlinear ordinary differential equation, leading to the formation of an algebraic equation system by collecting like terms of the unknown function and setting their coefficients to zero. The undetermined parameters, and consequently the solutions to the Biswas–Milovic equation, are derived by resolving this system. 3D, 2D, and contour graphs of the solution functions are plotted and interpreted to understand the physical behavior of the model. Furthermore, we also investigate the impact of the parameters such as the spatio-temporal dispersion and the parabolic nonlinearity on the behavior of the soliton. The new model and findings may contribute to the understanding and characterization of the nonlinear behavior of pulse propagation in optical fibers, which is crucial for the development of optical communication systems.