bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: The Role of Alkali Promoters in the Ag‐Catalyzed Epoxidation of Olefins
Authors: Monnier John R. 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hugo (Ugo) Schiff, Schiff Bases, and a Century of β‐Lactam Synthesis
Authors: Tidwell Thomas T. 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Development of Boron‐Based Reactions and Reagents for Organic Synthesis
Authors: Suginome Michinori 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Enantioselective α‐Fluorination of Carbonyl Compounds Using Chiral Transition Metal Complexes
Authors: Hamashima Yoshitaka , Sodeoka Mikiko 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Toward the Creation of High‐Performance Catalysts Based on Oligoarene Structures
Authors: Manabe Kei 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nanomaterials for Sensors
Authors: Bochenkov V. E. , Sergeev G. B. 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemical Modification of Polymeric Microchip Devices
Authors: Muck Alexander , Svatos Ales 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: NMR Spectroscopy: Pushing the Limits of Sensitivity
Authors: Spiess Hans Wolfgang 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Multiplexed Detection Methods for Profiling MicroRNA Expression in Biological Samples
Authors: Wark Alastair W. , Lee Hye Jin , Corn Robert M. 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Characterization of Flavonoids by Tandem Mass Spectrometry and Metal Complexation Strategies
Authors: Brodbelt Jennifer S. , Zhang Junmei , Pikulski Michael , Davis Barry D. , Girennavar Basavaraj , Jayaprakasha Guddadarangavvanahally K. , Patil Bhimanagouda S. 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Quantification of Myocardial Iron Overload by Cardiovascular Magnetic Resonance Imaging T2* and Review of the Literature
Authors: Kondur Ashok K. , Li Tao , Vaitkevicius Peter , Afonso Luis 
Published: April 2008

AbstractHeart failure due to myocardial iron overload remains the leading cause of death in patients with transfusion‐dependent anemias. Iron overload‐induced cardiomyopathy is reversible if intensive chelation therapy is instituted on time. Thus, early detection of myocardial iron deposition is imperative to prevent overt heart failure. Conventional cardiac monitoring, including physical examination, electrocardiography, echocardiography or serum ferritin levels fail to predict manifest or subclinical myocardial involvement resulting from iron overload. Cardiovascular magnetic resonance imaging T2* (cMRI‐T2*, pronounced T2 star) times correlate well with myocardial iron levels. This timely review focuses on the utility of cMRI‐T2*, for the preclinical detection of myocardial iron overload and monitoring of myocardial iron content during chelation therapy. Copyright © 2008 Wiley Periodicals, Inc.
In vivo MRI assessment of a novel GdIII‐based contrast agent designed for high magnetic field applications
Authors: de Sousa Paulo Loureiro , Livramento João Bruno , Helm Lothar , Merbach André E. , Même William , Doan Bich‐Thuy , Beloeil Jean‐Claude , Prata Maria I. M. , Santos Ana C. , C. Geraldes Carlos F. G. , Tóth Éva 
Published: April 2008

AbstractGd3L is a trinuclear Gd3+ complex of intermediate size, designed for contrast agent applications in high field magnetic resonance imaging (H12L is based on a trimethylbenzene core bearing three methylene‐diethylenetriamine‐ N,N,N″,N″‐tetraacetate moieties). Thanks to its appropriate size, the presence of two inner sphere water molecules and a fast water exchange, Gd3L has remarkable proton relaxivities at high magnetic field (r1 = 10.2 vs 3.0 mM−1 s−1 for GdDOTA at 9.4 T, 37°C, in H2O). Here we report an in vivo MRI feasibility study, complemented with dynamic γ scintigraphic imaging and biodistribution experiments using the 153Sm‐enriched analog. MRI experiments were performed at 9.4 T in mice with Gd3L and the commercial contrast agent gadolinium(III)‐1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetate (GdDOTA). Gd3L was well tolerated by the animals at the dose of 8 µmol Gd kg−1 body weight. Dynamic contrast enhanced (DCE) images showed considerably higher signal enhancement in the kidney medulla and cortex after Gd3L injection than after GdDOTA injection at an identical dose. The relaxation rates, ΔR1, were calculated from the IR TrueFISP data. During the excretory phase, the ΔR1 for various tissues was similar for Gd3L and GdDOTA, when the latter was injected at a three‐fold higher dose (24 vs 8 µmol Gd kg−1 body weight). These results point to an approximately three times higher in vivo relaxivity (per Gd) for Gd3L relative to GdDOTA, thus the ratio of the relaxivities of the two compounds determined in vitro is retained under in vivo conditions. They also indicate that the two inner sphere water molecules per Gd in Gd3L are not substantially replaced by endogenous anions or other donor groups under physiological conditions. Gd3L has a pharmacokinetics typical of small, hydrophilic complexes, involving fast renal clearance and no retention in the blood pool. The dynamic γ scintigraphic studies and the biodistribution experiments performed in Wistar rats with 153Sm‐enriched *Sm3L are also indicative of a fast elimination via the kidneys. Copyright © 2008 John Wiley & Sons, Ltd.
Oncofetal protein IMP3
Authors: Jiang Zhong , Lohse Christine M. , Chu Peigou G. , Wu Chin‐Lee , Woda Bruce A. , Rock Kenneth L. , Kwon Eugene D. 
Published: April 2008

AbstractBACKGROUND.Whether an oncofetal protein, IMP3, can serve as a prognostic biomarker to predict metastasis for patients with localized papillary and chromophobe subtypes of renal cell carcinomas (RCCs) was investigated.METHODS.The expression of IMP3 in 334 patients with primary papillary and chromophobe RCC from multiple medical centers was evaluated by immunohistochemistry. The 317 patients with localized papillary and chromophobe RCCs were further evaluated for outcome analyses.RESULTS.IMP3 was significantly increased in a subset of localized papillary and chromophobe RCCs that subsequently metastasized. Patients with localized IMP3‐positive tumors (n = 33; 10%) were over 10 times more likely to metastasize (risk ratio [RR], 11.38; 95% confidence interval [CI], 5.40‐23.96; P < .001) and were nearly twice as likely to die (RR, 1.91; 95% CI, 1.13–3.22; P = .016) compared with patients with localized IMP3 negative tumors. The 5‐year metastasis‐free and overall survival rates were 64% and 58% for patients with IMP3‐positive localized papillary and chromophobe RCCs compared with 98% and 85% for patients with IMP3 negative tumors, respectively. In multivariable analysis adjusting for the TNM stage and nuclear grade, patients with IMP3‐positive tumors were still over 10 times more likely to progress to distant metastasis (RR, 13.45; 95% CI, 6.00–30.14; P < .001) and were still nearly twice as likely die (RR, 1.95; 95% CI, 1.15–3.31; P = .013) compared with patients with IMP3‐negative tumors.CONCLUSIONS.IMP3 is an independent prognostic biomarker that can be used to identify a subgroup of patients with localized papillary and chromophobe RCC who are at high risk for developing distant metastasis. Cancer 2008. © 2008 American Cancer Society.
Basophil activation test by flow cytometry: Present and future applications in allergology
Authors: Ebo D. G. , Bridts C. H. , Hagendorens M. M. , Aerts N. E. , De Clerck L. S. , Stevens W. J. 
Published: April 2008

AbstractThe diagnosis of allergic reactions in clinical practice rests upon both clinical history and the demonstration of specific immunoglobulin E (sIgE), either in the serum or via skin tests. However, for various reasons, identification of the offending allergen(s) is not always possible. Moreover, not all allergies are IgE‐mediated. In an attempt to find reliable methods to investigate hypersensitivity reactions, histamine and sulfidoleukotriene release tests have long been introduced. However, relatively few comprehensive quality reports have been published so far. Upon challenge with a specific allergen, basophils not only secrete quantifiable bioactive mediators but also upregulate the expression of different markers which can be detected efficiently by flow cytometry using specific monoclonal antibodies. This review addresses the principals, particular technical aspects and pitfalls as well as the clinical and research applications of flow‐assisted analysis of in vitro activated basophils © 2008 Clinical Cytometry Society
Role of PI3Kδ and PI3Kγ in inflammatory arthritis and tissue localization of neutrophils
Authors: Randis Tara M. , Puri Kamal D. , Zhou Hairu , Diacovo Thomas G. 
Published: April 2008

AbstractThe p110δ isoform of class I phosphoinositide 3‐kinase (PI3K) plays a major role in B cell receptor signaling, while its p110γ counterpart is thought to predominate in leukocyte chemotaxis. Consequently, emphasis has been placed on developing PI3Kγ selective inhibitors to treat disease states that result from inappropriate tissue accumulation of leukocytes. We now demonstrate that PI3Kδ blockade is effective in treating an autoimmune disorder in which neutrophil infiltration is required for tissue injury. Using the K/BxN serum transfer model of arthritis, in which neutrophils and leukotriene B4 (LTB4) participate, we show that genetic deletion or selective inhibition of PI3Kδ diminishes joint erosion to a level comparable to its PI3Kγ counterpart. Moreover, the induction and progression of joint destruction was profoundly reduced in the absence of both PI3K isoforms and correlated with a limited ability of neutrophils to migrate into tissue in response to LTB4. However, the dynamic interplay between these isoforms is not pervasive, as fMLP‐induced neutrophil extravasation was primarily reliant on PI3Kγ. Our results not only demonstrate that blockade of PI3Kδ has potential therapeutic value in the treatment of chronic inflammatory conditions, but also provide evidence that dual inhibition of these lipid kinases may yield superior clinical results.Supporting Information for this article is available at www.wiley‐vch.de/contents/jc_2040/2008/38266_s.html
Plasticity in [(R4–xR1x)4N]4[Cu4{S2C2(CN)2}4] (x = 0–4) is Molded by a Guest Cation on an Elastic Anionic Host
Authors: Maiti Biplab K. , Pal Kuntal , Sarkar Sabyasachi 
Published: April 2008

AbstractThe elastic anion [Cu4(mnt)4]4– {mnt = maleonitriledithiolato, [S2C2(CN)2]2–} serves as a host to a series of guest cations [(R4–xR1x)4N]+ (R = Et, R1 = Me; x = 0–4) to form the complexes [(R4–xR1x)4N]4[Cu4{S2C2(CN)2}4]. The molecular structural design information stored in the cation is molded to the elastic anionic host‐framework through H‐bonding to create a plastic supramolecular entity. The reaction of CuCl with Na2(mnt) in a 1:1 metal/ligand ratio, followed by interaction with the respective cation, gives the cation‐dependenttetranuclear host‐guest assemblies [Me4N]4[Cu4(mnt)4] (1), [Me3EtN]4[Cu4(mnt)4] (2), [Me2Et2N]4[Cu4(mnt)4] (3), [MeEt3N]4[Cu4(mnt)4] (4) and [Et4N]4[Cu4(mnt)4] (5), which have been characterized by X‐ray structural studies in the solid state. The host cavity shrinks and expands, with varying Cu···Cu separations ranging from 2.754 to 3.952 Å, to accommodate the relevant guest ion during the crystallization process. All these complexes show identical 13C NMR and UV/Vis spectra in solution and their identical cyclic voltammetric redox behaviors also imply the presence of a common entity. The ESI mass spectra in acetonitrile confirm the presence of this common {Cu4(mnt)4} core. The elastic {Cu4(mnt)4} core participates in extensive hydrogen bonds in the presence of different quaternary cations in solution during the crystallization process and the cation determines the final shape of the anion in the solid state. Depending on the length and nature (symmetric or non‐symmetric) of the alkyl groups attached to the quaternary cation, the overall geometry of the anion assumes different degrees of openness in a partially opened umbrella shape. The {Cu4(mnt)4} moiety is cleaved by treatment with PPh3 to give a monomer, which has been isolated as [Et4N][Cu(mnt)PPh3] (6).(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Asymmetric Epoxidation of trans‐Chalcones Organocatalyzed by β‐Amino Alcohols
Authors: Russo Alessio , Lattanzi Alessandra 
Published: April 2008

AbstractCyclic and acyclic β‐amino alcohols were examined as organocatalysts in the epoxidation of trans‐chalcones with tert‐butyl hydroperoxide as the oxidant. Primary, secondary, and tertiary β‐amino alcohols are able to promote the reaction with variable activity and level of asymmetric induction. Subtle modifications to the structures of simple primary β‐amino alcohol strongly influenced their efficiency in the epoxidation. They are promising catalysts that afford trans‐chalcone epoxides in up to 52 % ee at room temperature.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Energy‐ and Charge‐Transfer Processes in a Perylene–BODIPY–Pyridine Tripartite Array
Authors: Alamiry Mohammed A. H. , Harriman Anthony , Mallon Laura J. , Ulrich Gilles , Ziessel Raymond 
Published: April 2008

AbstractA novel boron dipyrromethene (BODIPY) dye has been synthesized in which the F atoms, usually bound to the boron center, have been replaced with 1‐ethynylperylene units and a 4‐pyridine residue is attached at the meso‐position. The perylene units function as photon collectors over the wavelength range from 350 to 480 nm. Despite an unfavorable spectral overlap integral, rapid energy transfer takes place from the singlet‐excited state of the perylene unit to the adjacent BODIPY residue, which is itself strongly fluorescent. The mean energy‐transfer time is 7 ± 2 ps at room temperature. The dominant mechanism for the energy‐transfer process is Dexter‐type electron exchange, with Förster‐type dipole–dipole interactions accounting for less than 10 % of the total transfer probability. There are no indications for light‐induced electron transfer in this system, although there is evidence for a nonradiative decay channel not normally seen for F‐type BODIPY dyes. This new escape route is further exposed by the application of high pressure. The meso‐pyridine group is a passive bystander until protons are added to the system. Then, protonation of the pyridine N atom leads to complete extinction of fluorescence from the BODIPY dye and slight recovery of fluorescence from the perylene units. Quenching of BODIPY‐based fluorescence is due to charge‐transfer to the pyridinium unit whereas the re‐appearance of perylene‐based emission is caused by a reduction in the Förster overlap integral upon protonation. Other cations, most notably zinc(II) ions, bind to the pyridine N‐atom and induce similar effects but the resultant conjugate is weakly fluorescent.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Thermal Effects in the Organocatalytic Asymmetric α‐Amination of Disubstituted Aldehydes with Azodicarboxylates: A High‐Temperature Organocatalysis (Eur. J. Org. Chem. 13/2008)
Authors: Baumann Thomas , Bächle Michael , Hartmann Caroline , Bräse Stefan 
Published: April 2008

AbstractThe cover picture shows the use of L‐proline as an organocatalyst for the construction of nitrogen‐substituted quaternary carbon centres in the organocatalytic α‐amination of α,α‐disubstituted aldehydes. Since this reaction was found to be thermally accelerated, the use of microwave conditions resulted in a considerably reduced reaction time while both the yield and stereoselectivity were significantly increased. The beneficial effect of microwave irradiation may be associated with the quicker formation of intermediate dipolar adducts within the catalytic cycle. Details are presented in the article by S. Bräse et al. on p. 2207 ff. This picture has been provided by M. Bächle, one of the members in the author's group.
Nanofiltration/reverse osmosis for treatment of coproduced waters
Authors: Mondal Subrata , Hsiao Ching‐lun , Ranil Wickramasinghe S. 
Published: April 2008

AbstractCurrent high oil and gas prices have lead to renewed interest in exploration of nonconventional energy sources such as coal bed methane, tar sand, and oil shale. However oil and gas production from these nonconventional sources has lead to the coproduction of large quantities of produced water. While produced water is a waste product from oil and gas exploration it is a very valuable natural resource in the arid Western United States. Thus treated produced water could be a valuable new source of water.Commercially available nanofiltration and low pressure reverse osmosis membranes have been used to treat three produced waters. The results obtained here indicate that the permeate could be put to beneficial uses such as crop and livestock watering. However minimizing membrane fouling will be essential for the development of a practical process. Field Emission Scanning Electron Microscopy imaging may be used to observe membrane fouling. © 2008 American Institute of Chemical Engineers Environ Prog, 2008
A cross‐modal system linking primary auditory and visual cortices: Evidence from intrinsic fMRI connectivity analysis
Authors: Eckert Mark A. , Kamdar Nirav V. , Chang Catherine E. , Beckmann Christian F. , Greicius Michael D. , Menon Vinod 
Published: April 2008

AbstractRecent anatomical and electrophysiological evidence in primates indicates the presence of direct connections between primary auditory and primary visual cortex that constitute cross‐modal systems. We examined the intrinsic functional connectivity (fcMRI) of putative primary auditory cortex in 32 young adults during resting state scanning. We found that the medial Heschl's gyrus was strongly coupled, in particular, to visual cortex along the anterior banks of the calcarine fissure. This observation was confirmed using novel group‐level, tensor‐based independent components analysis. fcMRI analysis revealed that although overall coupling between the auditory and visual cortex was significantly reduced when subjects performed a visual perception task, coupling between the anterior calcarine cortex and auditory cortex was not disrupted. These results suggest that primary auditory cortex has a functionally distinct relationship with the anterior visual cortex, which is known to represent the peripheral visual field. Our study provides novel, fcMRI‐based, support for a neural system involving low‐level auditory and visual cortices. Hum Brain Mapp, 2008. © 2008 Wiley‐Liss, Inc.
An fMRI normative database for connectivity networks using one‐class support vector machines
Authors: Sato João Ricardo , da Graça Morais Martin Maria , Fujita André , Mourão‐Miranda Janaina , Brammer Michael John , Amaro Edson 
Published: April 2008

AbstractThe application of functional magnetic resonance imaging (fMRI) in neuroscience studies has increased enormously in the last decade. Although primarily used to map brain regions activated by specific stimuli, many studies have shown that fMRI can also be useful in identifying interactions between brain regions (functional and effective connectivity). Despite the widespread use of fMRI as a research tool, clinical applications of brain connectivity as studied by fMRI are not well established. One possible explanation is the lack of normal patterns and intersubject variability—two variables that are still largely uncharacterized in most patient populations of interest. In the current study, we combine the identification of functional connectivity networks extracted by using Spearman partial correlation with the use of a one‐class support vector machine in order construct a normative database. An application of this approach is illustrated using an fMRI dataset of 43 healthy subjects performing a visual working memory task. In addition, the relationships between the results obtained and behavioral data are explored. Hum Brain Mapp, 2009. © 2008 Wiley‐Liss, Inc.