bluuebunny/crossref_metadata_2025_split huggingface dataset:
A simple method for calculating left ventricular functions from angiographic data using a programmable hand calculator
Authors: Vogel John H. K. , Swenson Robert D. , Elings Virgil 
Published: February 2007

AbstractThe end diastolic volume and systolic ejection fraction have gained increasing acceptance as important indicators of ventricular performance. Time consuming calculations and lack of computer facilities have hindered the emergence of these calculations as a routine part of cardiac catheterization studies. The introduction of the programmable hand calculator has provided means for rapid analysis of ventricular volume data in an efficient and inexpensive manner. In this paper the step‐by‐step procedure for programming the hand calculator is given, as well as instructions for entering raw data and obtaining final calculations. Programs are given for both single plane and biplane cine angiographic studies.
Noninvasive diagnostic evaluation of the normal beall mitral prosthesis
Authors: Smith Ruth Ann , Kerber Richard E. , Snyder James W. 
Published: February 2007

AbstractPhonocardiography and echocardiography were used to examine 20 patients with a normally functioning Beall disc mitral valve prosthesis. Phonocardiographic intervals were: Q‐S1 interval 67 ± 3 msec; A2‐OC interval 118 ± 8 msec. Maximal variation of the Q‐S1 interval within one examination was 21 ± 2 msec, for A2‐OC interval it was 31 ± 5 msec. Echocardiographic disc velocities were: opening velocity 296 ± 30 mm/sec, closing velocity 414 ± 44 mm/sec. Maximal variation of the opening velocity was 126 ± 25 msec; maximal variation of the closing velocity was 334 ± 57 msec. Abnormal poppet function was suspected in one patient with unusual prolongation and variability of A2‐OC interval.
Coronary artery dissection—A complication of cardiac catheterization without sequelae: Case report and review of the literature
Authors: Meller Jose , Friedman Sanford , Dack Simon , Herman Michael V. 
Published: February 2007

AbstractThis report describes an acute right coronary artery dissection occurring during diagnostic cardiac catheterization. Following catheter manipulation in the vicinity of the aortic valve, the patient complained of mild chest discomfort and had transient electrocardiographic evidence of acute inferior wall myocardial infarction with runs of 2:1 atrioventricular block. Within 5 min, the EKG reverted to precatheterization appearance, and the patient was asymptomatic. Coronary angiography revealed a dissection of the proximal vessel without obstruction. The patient had no clinical sequelae while monitored in the intensive care unit. The patient underwent elective aortic and mitral valve replacement. The area of the dissection was directly visualized, and no abnormality was noted.We review the literature of spontaneous and iatrogenic coronary artery dissections with regard to pathology, diagnosis, and prognosis, and make recommendations for therapy.
Determination of the origin of elevated plasma cpk after cardiac catheterization
Authors: Roberts Robert , Sobel Burton E. , Ludbrook Philip A. 
Published: February 2007

AbstractEpisodes of chest pain are not uncommon in patients undergoing cardiac catheterization. The diagnostic implications of this symptom may be complicated by the occasional appearance of electrocardiographic changes mimicking those seen in acute myocardial infarction, and by the frequent elevation of conventionally measured serum enzymes. Exclusion of infarction is particularly important when coronary revascularization is contemplated. Since the MB CPK isoenzyme is relatively specific to myocardium, we assayed CPK isoenzymes in plasma samples from 184 patients undergoing cardiac catheterization to determine whether CPK elevations accompanying catheterization can be distinguished from those associated with myocardial infarction. Samples were obtained every 2 hr for 24 hr, and CPK isoenzymes quantified by a kinetic fluorometric method. Total plasma CPK increased in all patients (mean peak 0.238 ± 0.042 (SD) IU/ml) but MB CPK remained normal in 181 patients (< 0.005 IU/ml). In the three remaining patients, MB CPK was elevated and myocardial infarction was confirmed by 99mTc (SN) pyrophosphate scan. Twelve patients after catheterization, in whom no intramuscular premedication was given, exhibited only minimal elevation of total plasma CPK. In contrast, 100 control patients with acute myocardial infarction exhibited peak total CPK activity averaging 0.833 ± 0.037 (SD), and MB CPK was elevated in all cases (0.078 ± 0.027 (SD) IU/ml). Thus, CPK elevations after catheterization reflect release of enzyme from noncardiac sources rather than from injured myocardium. Furthermore, increased plasma MB CPK activity may be considered a reliable index of myocardial infarction in patients undergoing cardiac catheterization.
Systemic vasodilatation following diazepam after combined sympathetic and parasympathetic blockade in patients with coronary heart disease
Authors: Côté Pierre , Noble Jacques , Bourassa Martial G. 
Published: February 2007

AbstractClinical and hemodynamic benefits have been documented after giving diazepam to patients with coronary heart disease. The mechanisms by which this agent produces its hemodynamics effects are poorly understood. Partial autonomic blockade was induced in 10 patients by the intravenous administration of 5 mg propranolol and 0.8 mg atropine. Coronary and systemic hemodynamics were normal before and unchanged (p>0.05) after propranolol and atropine administration. However, myocardial extraction of lactate improved in 9 out of 10 patients (from 11% to 24%, p<0.05). The patients then received 0.1 mg/kg diazepam intravenously. Diazepam had no effect on the coronary sinus blood flow and resistance while myocardial extraction of lactate further improved in all but one patient (from 24% to 35% at 5 min and 34% at 15 min, p<0.05). Heart rate increased by a mean of 4 beats at 5 min (p<0.01). Cardiac output was unchanged. Systolic arterial pressure (SAP) decreased significantly (p<0.001) at 5 and 15 min (6–10%) and left ventricular end‐diastolic pressure (LVEDP) also diminished significantly (p<0.001) at 5 and 15 min (18–19%). These changes occurred despite autonomic blockade. These findings suggest, in the absence of change of myocardial blood flow and contractility, a direct peripheral action of the drug on arteries and/or veins.
Technique for transjugular placement of an umbrella filter in a left inferior vena cava
Authors: Grollman J. H. , Gray Robert K. 
Published: February 2007

AbstractTransjugular placement of a Mobin‐Uddin umbrella filter in an anomalous left inferior vena cava to prevent recurrent pulmonary embolization may present technical difficulties. Preforming a slight curve in the applicator wire a short distance from its tip allowed catheterization and proper position of a filter in two cases.
Pulmonary artery wedge pressures in congenital heart disease
Authors: Neches William H. , Park Sang C. , Lenox Cora C. , Zuberbuhler J. R. , Mullins Charles E. , McNamara Dan G. 
Published: February 2007

AbstractThe bilateral measurement of pulmonary artery wedge pressure is essential in the cardiac catheterization evaluation of all patients with pulmonary artery hypertension. Five cases of pulmonary venous obstruction are presented, 4 of whom had additional intracardiac defects. The pulmonary artery hypertension in these 4 patients was initially attributed to the associated cardiac anomalies and because the left atrium had been entered directly with the catheter in each case, pulmonary artery wedge to the left atrium pressure gradients were initially either not obtained or were discounted as being artificial. Pulmonary venous obstruction was recognized in all 5 cases on the basis of an elevated pulmonary artery wedge pressure, and the anatomic site of the obstruction was successfully documented. Unless bilateral pulmonary artery wedge pressures are measured in all patients with pulmonary artery hypertension regardless of the presence of additional cardiac anomalies, a surgically correctable cause of pulmonary hypertension may be overlooked.
Myocardial bridges in man: Clinical correlations and angiographic accentuation with nitroglycerin
Authors: Ishimori Tetsuo , Raizner Albert E. , Chahine Robert A. , Awdeh Mahir , Luchi Robert J. 
Published: February 2007

AbstractLittle is known of the clinical significance of myocardial bridges, which may be recognized angiographically as systolic coronary artery narrowing (SCAN). A retrospective review of a 1 year's experience (313 consecutive coronary arteriograms) revealed 5 patients with SCAN, an incidence of 1.6%. SCAN involved the proximal and/or middle segments of the left anterior descending coronary artery in all patients. It is of particular note that the administration of nitroglycerin noticeably accentuated the SCAN phenomenon in each of 3 patients to whom it was administered.Four of the 5 patients had left ventricular hypertrophy due to hypertrophic car‐diomyopathy (2), aortic stenosis (1), and hypertension (1). All 5 patients with the SCAN phenomenon had anginal chest pains, and critical obstructive coronary atherosclerosis was observed in only 2 cases. The other 3 patients showed, otherwise, normal coronary arteriograms.Thus, myocardial bridges appear to be angiographically manifest predominantly in patients with cardiac hypertrophy. Nitroglycerin, which accentuates SCAN, might be useful as a provocative test to enhance the angiographic recognition of this phenomenon. The possible role of myocardial bridges in the production of myocardial ischemia warrants further investigation.
A simplified method of echocardiographic data analysis
Authors: Schieken Richard M. , Jordan Horst R. , Clarke William , Lauer Ronald M. 
Published: February 2007

AbstractRapid accurate analysis of echocardiographic data is accomplished using a sonic digitizer and programmable calculator. This method allows the echocardiographer to select technically optimal areas of the recording for analysis. The resolution of the measuring device is 0.1 mm. A hardcopy printout of both measurement and calculation is provided. Instead of expensive on‐line computer, an inexpensive programmable calculator is used.
Preformed catheters for simplified transbrachial coronary arteriography
Authors: Co Eddy D. , Yap Vicente , Keelan Michael H. 
Published: February 2007

AbstractThe experience in 700 patients of transbrachial selective coronary arteriography using a preformed catheter is described. The excellent plastic memory and torque control of the polyurethane catheter combined with the characteristic gentle curve permit rapid and easy intubation of the coronary arteries. The so‐called „difficult”︁ cases encountered with the classic Sones technique have been catheterized with ease employing the technique described in this report. The exceptionally low complication rate (no deaths), abbreviated catheterization time, a success rate of 99.2%, and the high quality cine angiographic films make this technique a highly useful and effective method of transbrachial coronary arteriography.
Safety and feasibility of acute percutaneous septal sinus shortening: First‐in‐human experience
Authors: Palacios Igor F. , Condado José A. , Brandi Sergio , Rodriguez Victor , Bosch Fernando , Silva Gaston , Low Reginald I. , Rogers Jason H. 
Published: February 2007

AbstractBackground:Multiple percutaneous therapies for the treatment of functional and ischemic mitral regurgitation (FMR/IMR) are under development. We previously reported a novel percutaneous technique, the percutaneous septal sinus shortening [PS3] System™, which was effective in ameliorating FMR in an animal model. We herein report results from the first‐in‐human safety and feasibility pilot study involving the PS3 System.Methods and Results:The primary objective of this first‐in‐human study was to evaluate the safety and feasibility of acute percutaneous septal‐lateral shortening by using the PS3 System in patients immediately prior to clinically‐indicated surgical mitral valve repair. Two patients were enrolled. Patient One had severe aortic insufficiency with moderate functional mitral regurgitation. The PS3 System reduced the MR grade from 2+ to 1+ with a decrease in the mean septal‐lateral systolic (SLS) dimension from 38 to 27 mm (29% reduction). Patient Two had severe ischemic mitral regurgitation in the setting of severe multi‐vessel disease and prior infero‐posterior infarct. MR grade was reduced from 3+ to 1+ with a decrease in the mean SLS dimension from 36 to 25mm (31% reduction). There were no procedural complications and both patients proceeded to pre‐planned cardiac surgery, where the devices were explanted under direct visualization.Conclusions:The PS3 System has been safely translated from the preclinical setting to first‐in‐human implantation. Both patients studied experienced a reduction in MR after device implantation, with significant SLS shortening. Further clinical trials will be needed to assess long‐term efficacy and durability. © 2007 Wiley‐Liss, Inc.
Late DES thrombosis: A lot of smoke, very little fire?
Authors: Fischell Tim A. , Holmes David R. 
Published: February 2007

AbstractRecent studies and editorials have stirred controversy and generated tremendous publicity in the lay press related to the safety of drug‐eluting stents (DES) for the treatment of coronary artery disease. Questions have been raised regarding the risks of late, or very late stent thrombosis with DES. The purpose of this editorial and review of stent thrombosis is to illuminate some counterpoints to some of the attention surrounding the issues of late DES thrombosis. The risks of DES stent thrombosis versus BMS may have been overstated by flawed studies. Late stent thrombosis does occur with both BMS and DES, and may or may not be modestly higher with DES. The time course of very late “DES thrombosis,” suggests that peristent plaque ruptures and disease progression in the target vessel may cause some, or many of these events. There is still much to be learned about the biology of DES. Although there is a small risk of late thrombosis with DES, there is little question that this technology provides benefit to the vast majority of patients compared with prior revascularization strategies, using balloon angioplasty, BMS, or bypass surgery. Substantial resources should be devoted to creating more biocompatible DES systems, and to minimizing the risks of both early and late stent thrombosis. © 2007 Wiley‐Liss, Inc.
Fenestrated endovascular grafts for juxtarenal aortic aneurysms: A step by step technical approach
Authors: Moore Randy , Hinojosa Carlos A. , O'Neill Sean , Mastracci Tara M. , Cinà Claudio S. 
Published: February 2007

AbstractFenestrated endovascular aortic aneurysm repair is a valuable alternative for patients who are at high risk for open surgery, but have unsuitable anatomy for infrarenal endovascular repair due to a short aneurysmal neck. Recognizing that this is an evolving and complex technology, we present a step by step approach to the surgical technique that may be useful for endovascular therapist interested in the management of these complex patients. © 2007 Wiley‐Liss, Inc.
Early restenosis following biodegradable stent implantation in an aortopulmonary collateral of a patient with pulmonary atresia and hypoplastic pulmonary arteries
Authors: McMahon Colin J. , Oslizlok Paul , Walsh Kevin P. 
Published: February 2007

AbstractTraditionally, the implantation of stents in young children with small blood vessels has been avoided as the presence of a metallic or fixed stent structure limits the ability to further dilate the stent with vessel growth. Pulmonary atresia with ventricular septal defect and hypoplastic pulmonary arteries represents one such cohort where the placement of fixed nondegradable stents has been difficult. We report a 2‐month‐old girl with pulmonary atresia, VSD, and multiple aorto‐pulmonary collaterals with severely hypoplastic pulmonary arteries who underwent placement of a biodegradeable magnesium stent within a stenotic aorto‐pulmonary collateral. Although there was an initial significant increase in vessel diameter, significant restenosis occurred 4 months after stent placement. This to our knowledge represents the first case of the use of biodegradable stents in a child with severely hypoplastic pulmonary arteries. Although further refinements in stent technology are required, this development will hopefully usher in a new era of potential intervention in children previously deemed unsuitable for stent placement. © 2007 Wiley‐Liss, Inc.
A Microstructure Heat Exchanger for Quenching the Metabolism of Mammalian Cells
Authors: Wiendahl C. , Brandner J. J. , Küppers C. , Luo B. , Schygulla U. , Noll T. , Oldiges M. 
Published: February 2007

AbstractMetabolomics, the quantification of intracellular metabolites, is a powerful tool that has proven useful in microbial strain and fermentation process development. The crucial step is the rapid quenching of the cellular metabolism to preserve the intracellular situation as it is in the bioreactor until (MS‐based) analysis. For microbial systems and plants this can be achieved by using ice‐cold methanol (–40 °C) or liquid nitrogen, but for mammalian cells in suspension no reliable technique is yet available. Here, a metallic microstructure heat exchanger is presented which allows cooling of a CHO cell suspension from cultivation temperature (37 °C) to 0 °C in less than one second without any detectable cell damage or cell disruption even at very high cell densities up to 8 · 106 cells/mL.
Herstellung von funktionalisierten oxidischen Nano‐ und Mikropartikeln und deren Verwendung
Authors: Gellermann C. , Ballweg T. , Wolter H. 
Published: February 2007

AbstractDas Fraunhofer‐Institut für Silicatforschung ISC beschäftigt sich bereits seit vielen Jahren mit der Synthese, Charakterisierung und Verarbeitung von Partikeln auf Basis nichtmetallischer Verbindungen. Beispielsweise werden anorganische und hybride Mikro‐ und Nanopartikel für keramische, optische und medizinische Anwendungen entwickelt. Es handelt sich im Gegensatz zum klassischen Mahlgut bevorzugt um kugelförmige Partikel. Hergestellt werden sie über nasschemische Verfahren wie Emulsions‐ und Fällverfahren, Sol‐Gel‐Technologie oder Aerosolmethoden.
Allicin inhibits cell polarization, migration and division via its direct effect on microtubules
Authors: Prager‐Khoutorsky Masha , Goncharov Igor , Rabinkov Aharon , Mirelman David , Geiger Benjamin , Bershadsky Alexander D. 
Published: February 2007

AbstractAllicin (diallyl thiosulfinate) is a major biologically active component of garlic that is known to inhibit cell proliferation and induce apoptosis. The effects of allicin are attributed to its ability to react with thiol groups. However, the mechanism underlying the cytostatic activity of allicin, as well as the identity of the relevant subcellular targets, are not known. In the present study, we found that the effects of allicin on cell polarization, migration, and mitosis are similar to the effects of microtubule‐depolymerizing drugs such as nocodazole. Moreover, treatment of cultured fibroblasts with micromolar doses of allicin results in microtubule depolymerization in cells within minutes of its application, without disrupting the actin cytoskeleton or inducing direct cytotoxic effects. Furthermore, allicin blocks the polymerization of pure tubulin in vitro in a concentration‐dependent manner, suggesting that it acts directly on tubulin dimers. Sulfhydryl (SH)‐reducing reagents such as 2‐mercaptoethanol and dithiothreitol abolish the effect of allicin on microtubule polymerization. Thus, allicin is a potent microtubule‐disrupting reagent interfering with tubulin polymerization by reaction with tubulin SH groups. Cell Motil. Cytoskeleton 2007. © 2007 Wiley‐Liss, Inc.
Accelerated mortality from hydrocephalus and pneumonia in mice with a combined deficiency of SPAG6 and SPAG16L reveals a functional interrelationship between the two central apparatus proteins
Authors: Zhang Zhibing , Tang Waixing , Zhou Rong , Shen Xuening , Wei Zhangyong , Patel Aatish M. , Povlishock John T. , Bennett Jean , Strauss Jerome F. 
Published: February 2007

AbstractSPAG6 and SPAG16L are proteins localized to the “9+2” axoneme central apparatus. Both are essential for sperm motility and male fertility. These two proteins are also expressed in other tissues containing ciliated cells, such as brain and lung. To study the effects of combined deficiency of these two proteins, a double mutant mouse model was created. The double mutant mice displayed a more profound phenotype of growth retardation and hydrocephalus compared to mice nullizygous for SPAG6 and SPAG16L alone. The double mutant mice died younger, and mortality was significantly higher than in single mutant mice. In addition, the double mutant mice demonstrated pneumonia and its complications, including hemorrhage, edema, and atelectasis, phenotypes not observed in mice nullizygous for mutations in the individual genes. No other cilia‐related phenotypic change was detected in double mutant mice including lateralization defects. The ultrastructure of cilia in both the brain and lung of the double mutant mice appeared normal. This model of combined SPAG6 and SPAG16L deficiency provides a new platform to study primary ciliary dyskinesia. The findings also demonstrate that SPAG6 and SPAG16L have related roles in controlling the function of cilia in the brain and lung. Cell Motil. Cytoskeleton 2007. © 2007 Wiley‐Liss, Inc.
EhGEF3, a novel Dbl family member, regulates EhRacA activation during chemotaxis and capping in Entamoeba histolytica
Authors: Arias‐Romero Luis E. , de la Rosa Claudia H. Gonzalez , Almaráz‐Barrera Ma. de Jesús , Diaz‐Valencia Juan D. , Sosa‐Peinado Alejandro , Vargas Miguel 
Published: February 2007

AbstractRho GTPases are critical elements involved in the regulation of signal transduction cascades from extracellular stimuli to cytoskeleton. The Rho guanine nucleotide exchange factors (RhoGEFs) have been implicated in direct activation of these GTPases. Here, we describe a novel RhoGEF, denominated EhGEF3 from the parasite Entamoeba histolytica, which encodes a 110 kDa protein containing the domain arrangement of a Dbl homology domain in tandem with a pleckstrin homology domain, the DH domain of EhGEF3 is closely related with the one of the Vav3 protein. Biochemical analysis revealed that EhGEF3 is capable of stimulating nucleotide exchange on the E. histolytica EhRacA and EhRho1 GTPases in vitro, however only a partial GEF activity toward Cdc42 was observed. Conserved residue analysis showed that the N816 and L817 residues are critical for EhGEF3 activity. Cellular studies revealed that EhGEF3 colocalises with EhRacA in the rear of migrating cells, probably regulating the retraction of the uroid and promoting the activation of these GTPase during the chemotactic response toward fibronectin, and that EhGEF3 also regulates EhRacA activation during the capping of cell receptors. These results suggest that EhGEF3 should have a direct role in activating EhRacA, and in bringing the activated GTPase to specific target sites such as the uroid. Cell Motil. Cytoskeleton 2007. © 2007 Wiley‐Liss, Inc.