bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum antibodies against human albumin in critically ill and healthy dogs
Authors: Martin Linda G. , Luther Teresa Y. , Alperin Debra C. , Gay John M. , Hines Stephen A. 
Published: April 2008

Abstract
Objective—To characterize the magnitude and duration of the antibody response against human albumin (HA) in critically ill and healthy dogs.
Design—Cohort and cross-sectional study.
Animals—Fourteen critically ill dogs that received 25% HA as part of their treatment protocol, 2 healthy dogs with no known previous exposure to HA that received 2 infusions of 25% HA (positive control dogs), and 47 healthy dogs and 21 critically ill dogs with no known exposure to HA (negative control dogs).
Procedures—An ELISA to detect IgG against HA was developed. Serum samples were obtained from the critically ill dogs prior to infusion of HA, at the time of hospital discharge, and 4 to 6 weeks and 6 months after HA administration. Serum samples were obtained at 2- to 4-week intervals from both positive control dogs for 101 weeks. A single serum sample was obtained from each of the negative control dogs.
Results—All 14 critically ill dogs developed serum IgG against HA. Peak antibody response was detected 4 to 6 weeks after HA administration. In both positive control dogs, IgG against HA was detected 10 days after HA administration and continued past 97 weeks. The peak antibody response was detected at 3 weeks in 1 dog and at 9 weeks in the other. Five of the 68 (7%) negative control dogs had a positive antibody response.
Conclusions and Clinical Relevance—Results suggested that dogs developed a pronounced IgG response following exposure to HA and that some dogs with no history of HA administration were positive for anti-HA IgG.
Preputial damage and lateral penile displacement during castration in a degu
Authors: Powers Michelle Y. , Campbell Bonnie G. , Finch Nickol P. 
Published: April 2008

Abstract
Case Description—A 2-month-old male degu was treated for preputial damage and lateral penile displacement that occurred during attempted castration.
Clinical Findings—Bruising and swelling of the prepuce and severe edema to the left of the prepuce were evident. The penis could not be extruded from the prepuce. Radiography revealed a large bladder. Contrast medium injected into the prepuce filled the peripreputial subcutaneous tissues.
Treatment and Outcome—During surgical exploration through a peripreputial approach, the penis was found to be completely separated from the prepuce and located in the adjacent subcutaneous tissue. The penis was repositioned in the prepuce and anchored with a suture at its base. The following day, the preputial orifice was crusted over, urine was leaking from the incision, and the penis could not be extruded from the prepuce. The anchoring suture was removed, and the tip of the penis was sutured to the preputial orifice so that the penis protruded slightly from the prepuce. Urination was normal after the second surgery. Two years later, the preputial orifice remained adhered to the distal portion of the penis and the exposed penile tissue was healthy.
Clinical Relevance—Penile displacement from the prepuce is an unusual complication of castration in degus. The surgical technique used in this animal may be an effective means of repair. Permanent exposure of the tip of the penis may be well-tolerated in degus.
Use of cystoscopic-guided laser ablation for treatment of intramural ureteral ectopia in male dogs: four cases (2006–2007)
Authors: Berent Allyson C. , Mayhew Philipp D. , Porat-Mosenco Yael 
Published: April 2008

Abstract
Objective—To describe and evaluate the outcome of cystoscopic-guided laser ablation of intramural ureteral ectopia in male dogs.
Design—Retrospective case series.
Animals—4 incontinent male dogs with intramural ureteral ectopia.
Procedures—Intramural ectopic ureters were diagnosed via preoperative computed tomography–IV urography and subsequent cystoscopy. Transurethral cystoscopic-guided laser ablation (diode laser [n = 3 dogs] and holmium:yttrium aluminum garnet laser [1]) was performed to proximally relocate the ectopic ureteral orifice to the urinary bladder. Fluoroscopy was used during the procedures to confirm that the ureteral tract was intramural and the ureteral orifice was intravesicular after the procedure. In 1 dog with bilateral ureteral ectopia, staged laser ablation was performed at 6-week intervals because of difficulty viewing the second ureter on the first attempt. All ureteral orifices were initially located in the middle to proximal portion of the prostatic portion of the urethra. Six weeks after surgery, imaging was repeated in 3 of 4 dogs.
Results—Postoperative dysuria or hematuria did not develop. All dogs were immediately continent after laser treatment and remained so at a median follow-up period of 18 months (range, 15 to 20 months) without medical management.
Conclusions and Clinical Relevance—Ureteral ectopia can cause urinary incontinence in male dogs and is usually associated with other urinary tract abnormalities. Cystoscopicguided laser ablation provided an effective and minimally invasive alternative to surgical management of intramural ureteral ectopia.
Chemoprophylactic effects of azithromycin against Rhodococcus equi–induced pneumonia among foals at equine breeding farms with endemic infections
Authors: Chaffin M. Keith , Cohen Noah D. , Martens Ronald J. 
Published: April 2008

Abstract
Objective—To determine the effect of azithromycin chemoprophylaxis on the cumulative incidence of pneumonia caused by Rhodococcus equi, age at onset of pneumonia, and minimum inhibitory concentration (MIC) of azithromycin for R equi isolates cultured from fecal and clinical samples.
Design—Controlled, randomized clinical trial.
Animals—338 foals born and raised at 10 equine breeding farms; each farm had a history of endemic R equi infections.
Procedures—Group 1 foals were control foals, and group 2 foals were treated with azithromycin (10 mg/kg [4.5 mg/lb], PO, q 48 h) during the first 2 weeks after birth. Foals were monitored for development of pneumonia attributable to R equi infection and for adverse effects of azithromycin. Isolates of R equi were tested for susceptibility to azithromycin.
Results—The proportion of R equi–affected foals was significantly higher for control foals (20.8%) than for azithromycin-treated foals (5.3%). Adverse effects of azithromycin treatment were not detected, and there were no significant differences between groups for the MICs of azithromycin for R equi isolates cultured from fecal or clinical samples.
Conclusions and Clinical Relevance—Azithromycin chemoprophylaxis effectively reduced the cumulative incidence of pneumonia attributable to R equi among foals at breeding farms with endemic R equi infections. There was no evidence of resistance to azithromycin. Nonetheless, caution must be used because it is possible that resistance could develop with widespread use of azithromycin as a preventative treatment. Further investigation is needed before azithromycin chemoprophylaxis can be recommended for control of R equi infections.
The 2023 International Planning Competition
Authors: Taitler Ayal , Alford Ron , Espasa Joan , Behnke Gregor , Fišer Daniel , Gimelfarb Michael , Pommerening Florian , Sanner Scott , Scala Enrico , Schreiber Dominik , Segovia‐Aguas Javier , Seipp Jendrik 
Published: April 2024

AbstractIn this article, we present an overview of the 2023 International Planning Competition. It featured five distinct tracks designed to assess cutting‐edge methods and explore the frontiers of planning within these settings: the classical (deterministic) track, the numeric track, the Hierarchical Task Networks (HTN) track, the learning track, and the probabilistic and reinforcement learning track. Each of these tracks evaluated planning methodologies through one or more subtracks, with the goal of pushing the boundaries of current planner performance. To achieve this objective, the competition introduced a combination of well‐established challenges and entirely novel ones. Within this article, each track offers an exploration of its historical context, justifies its relevance within the planning landscape, discusses emerging domains and trends, elucidates the evaluation methodology, and ultimately presents the results.
Image quality characterization of an ultra‐high‐speed kilovoltage cone‐beam computed tomography imaging system on an O‐ring linear accelerator
Authors: Kim Euidam , Park Yang Kyun , Zhao Tianyu , Laugeman Eric , Zhao Xiaodong Neo , Hao Yao , Chung Yoonsun , Lee Hugh 
Published: April 2024

AbstractPurposeThe quality of on‐board imaging systems, including cone‐beam computed tomography (CBCT), plays a vital role in image‐guided radiation therapy (IGRT) and adaptive radiotherapy. Recently, there has been an upgrade of the CBCT systems fused in the O‐ring linear accelerators called HyperSight, featuring a high imaging performance. As the characterization of a new imaging system is essential, we evaluated the image quality of the HyperSight system by comparing it with Halcyon 3.0 CBCT and providing benchmark data for routine imaging quality assurance.MethodsThe HyperSight features ultra‐fast scan time, a larger kilovoltage (kV) detector, a more substantial kV tube, and an advanced reconstruction algorithm. Imaging protocols in the two modes of operation, treatment mode with IGRT and the CBCT for planning (CBCTp) mode were evaluated and compared with Halcyon 3.0 CBCT. Image quality metrics, including spatial resolution, contrast resolution, uniformity, noise, computed tomography (CT) number linearity, and calibration error, were assessed using a Catphan and an electron density phantom and analyzed with TotalQA software.ResultsHyperSight demonstrated substantial improvements in contrast‐to‐noise ratio and noise in both IGRT and CBCTp modes compared to Halcyon 3.0 CBCT. CT number calibration error of HyperSight CBCTp mode (1.06%) closely matches that of a full CT scanner (0.72%), making it suitable for adaptive planning. In addition, the advanced hardware of HyperSight, such as ultra‐fast scan time (5.9 s) or 2.5 times larger heat unit capacity, enhanced the clinical efficiency in our experience.ConclusionsHyperSight represented a significant advancement in CBCT imaging. With its image quality, CT number accuracy, and ultra‐fast scans, HyperSight has a potential to transform patient care and treatment outcomes. The enhanced scan speed and image quality of HyperSight are expected to significantly improve the quality and efficiency of treatment, particularly benefiting patients.
Topological Phonons and Thermoelectric Conversion in Crystalline Materials
Authors: Ding Zhong‐Ke , Zeng Yu‐Jia , Liu Wangping , Tang Li‐Ming , Chen Ke‐Qiu 
Published: April 2024

AbstractTopological phononics, a fascinating frontier in condensed matter physics, holds great promise for advancing energy‐related applications. Topologically nontrivial phonons typically possess gapless edge or surface states. These exotic states of lattice vibrations, characterized by their nontrivial topology, offer unique opportunities for manipulating and harnessing energy transport. The exploration of topological phonons opens new avenues in understanding and controlling thermal transport properties, with potential applications in fields such as thermoelectric materials, phononic devices, and waste heat recovery. Here, an overview of concepts such as Berry curvature and topological invariants, along with the applications of phonon tight‐binding method and nonequilibrium Green's function method in the field of topological phononics is provided. This review encompasses the latest research progress of various topological phonon states within crystalline materials, including topological optical phonons, topological acoustical phonons, and higher‐order topological phonons. Furthermore, the study delves into the prospective applications of topological phonons in the realm of thermoelectric conversion, focusing on aspects like size effects and symmetry engineering.
Regulating Phase Transition and Restraining Fe Distortion at High Potential Window via Rare Earth Metal Incorporation on O3‐Type Layered Cathodes
Authors: Hong Ningyun , Li Jianwei , Wang Haoji , Hu Xinyu , Zhao Bin , Hua Fang , Mei Yu , Huang Jiangnan , Zhang Baichao , Jian WeiShun , Gao Jinqiang , Tian Yuan , Shi Xixi , Deng Wentao , Zou Guoqiang , Hou Hongshuai , Hu Zhanggui , Long Zhen , Ji Xiaobo 
Published: April 2024

AbstractRapid capacity fading and structural collapse, along with other deep‐rooted challenges in the high‐voltage region, are insufficient to meet the requirements for commercial applications of O3‐type layered cathodes. Hereby, rare earth metal (RE) within the IIIB group are utilized as the robust dopants for O3‐NaNi1/3Fe1/3Mn1/3O2 (NFM) to achieve the purpose of reconstructing the crystal lattice and regulating the interlayer structure. The inactive RE3+ acts as a pillar, reinforces the TMO6 octahedron, and broadens the Na+ diffusion layer in the configuration of O‐Na‐O‐TM (RE)‐O‐Na‐O, giving rise to the enhanced crystal stability and accelerating the transmission of sodium ions. More impressively, the scandium incorporation is working as a “vitamin” that improves Ni/Fe redox reversibility, alleviating the irreversible P3‐O3’‐P3’ phase transformation and further restraining the disordered Fe migration into the neighboring Na layer, which is firmly validated by in situ X‐ray diffraction coupled with the synchrotron X‐ray absorption spectroscopy. Consequently, the as‐designed NFM‐Sc exhibits impressive rate capability (82.5 mAh g−1 at 10 C) and excellent cycle stability with 80.2% capacity retention after 500 cycles at the high voltage of 4.2 V. Given this, the elaborate work may shed new insight into the operational mechanism of rare metal through strategically regulating the structure for sodium‐ion batteries.
New Prospects Arising from Dynamically Crosslinked Polymers: Reprogramming Their Properties
Authors: Jia Yunchao , Qian Jingjing , Hao Senyuan , Zhang Shijie , Wei Fengchun , Zheng Hongjuan , Li Yilong , Song Jingwen , Zhao Zhiwei 
Published: April 2024

AbstractDynamically crosslinked polymers (DCPs) have gained significant attention owing to their applications in fabricating (re)processable, recyclable, and self‐healable thermosets, which hold great promise in addressing ecological issues, such as plastic pollution and resource scarcity. However, the current research predominantly focuses on redefining and/or manipulating their geometries while replicating their bulk properties. Given the inherent design flexibility of dynamic covalent networks, DCPs also exhibit a remarkable potential for various novel applications through postsynthesis reprogramming their properties. In this review, the recent advancements in strategies that enable DCPs to transform their bulk properties after synthesis are presented. The underlying mechanisms and associated material properties are overviewed mainly through three distinct strategies, namely latent catalysts, material‐growth, and topology isomerizable networks. Furthermore, the mutual relationship and impact of these strategies when integrated within one material system are also discussed. Finally, the application prospects and relevant issues necessitating further investigation, along with the potential solutions are analyzed.
Femtosecond‐Laser Direct‐Writing Hydrogel‐Based Microlens Arrays Customized with Multi‐Dimensional Optical Configurations for Information Encryption
Authors: Li Qi‐Song , Shi Hao‐Song , Xi Shan‐Ming , Xu Zhi‐Hui , Zhang Long , Liu Yi 
Published: April 2024

AbstractFemtosecond‐laser direct‐writing lithography prints tunable 3D micro/nano‐scale optical devices based on hydrogel materials have garnered significant attention owing to their use in optical applications. Although the refractive index (RI) is an important parameter of optical devices, a quantitative measurement to determine that of femtosecond‐laser‐induced microstructures is lacking. This study proposes a novel method to measure the RI change of a tunable hydrogel device in different environments using a femtosecond‐laser‐customized multidimensional grating. As hydrogels can be tuned by changing the pH values, the specific RI changes of a hydrogel are first quantitatively investigated with different pH values such that the proposed method can be employed to precisely control the dynamic and tunable optical performance of hydrogel optical devices. To this end, a 3D hydrogel microlens array (HMA) with variable focal lengths is designed and manufactured to verify its dynamic and tunable optical performances. The HMA displays reversible and tunable imaging capabilities, confirming its application in information encryption. As a proof of concept, a customized sequence of letters “CFAE” is successfully obtained as the “output” by assigning the pre‐set pH values as the “code” and the original letter sequence as the “input.”
Ultrasound Trigger Ce‐Based MOF Nanoenzyme For Efficient Thrombolytic Therapy
Authors: Shan Jianggui , Du Ling , Wang Xingang , Zhang Sidi , Li Yiping , Xue Song , Tang Qianyun , Liu Peifeng 
Published: April 2024

AbstractThe inflammatory damage caused by thrombus formation and dissolution can increase the risk of thrombotic complications on top of cell death and organ dysfunction caused by thrombus itself. Therefore, a rapid and precise thrombolytic therapy strategy is in urgent need to effectively dissolve thrombus and resist oxidation simultaneously. In this study, Ce‐UiO‐66, a cerium‐based metal–organic framework (Ce‐MOF) with reactive oxygen species (ROS) scavenging properties, encapsulated by low‐immunogenic mesenchymal stem cell membrane with inflammation‐targeting properties, is used to construct a targeted nanomedicine Ce‐UiO‐CM. Ce‐UiO‐CM is applied in combination with external ultrasound stimulation for thrombolytic therapy in rat femoral artery. Ce‐UiO‐66 has abundant Ce (III)/Ce (IV) coupling sites that react with hydrogen peroxide (H2O2) to produce oxygen, exhibiting catalase (CAT) activity. The multi‐cavity structure of Ce‐UiO‐66 can generate electron holes, and its pore channels can act as micro‐reactors to further enhance its ROS scavenging capacity. Additionally, the porous structure of Ce‐UiO‐66 and the oxygen produced by its reaction with H2O2 may enhance the cavitation effects of ultrasound, thereby improving thrombolysis efficacy.
Fine Optimization of Colloidal Photonic Crystal Structural Color for Physically Unclonable Multiplex Encryption and Anti‐Counterfeiting
Authors: Gao Yifan , Ge Kongyu , Zhang Zhen , Li Zhan , Hu Shaowei , Ji Hongjun , Li Mingyu , Feng Huanhuan 
Published: April 2024

AbstractRobust anti‐counterfeiting techniques aim for easy identification while remaining difficult to forge, especially for high‐value items such as currency and passports. However, many existing anti‐counterfeiting techniques rely on deterministic processes, resulting in loopholes for duplication and counterfeiting. Therefore, achieving high‐level encryption and easy authentication through conventional anti‐counterfeiting techniques has remained a significant challenge. To address this, this work proposes a solution that combined fluorescence and structural colors, creating a physically unclonable multiplex encryption system (PUMES). In this study, the physicochemical properties of colloidal photonic inks are systematically adjusted to construct a comprehensive printing phase diagram, revealing the printable region. Furthermore, the brightness and color saturation of inkjet‐printed colloidal photonic crystal structural colors are optimized by controlling the substrate's hydrophobicity, printed droplet volume, and the addition of noble metals. Finally, fluorescence is incorporated to build PUMES, including macroscopic fluorescence and structural color patterns, as well as microscopic physically unclonable fluorescence patterns. The PUMES with intrinsic randomness and high encoding capacity are authenticated by a deep learning algorithm, which proved to be reliable and efficient under various observation conditions. This approach can provide easy identification and formidable resistance against counterfeiting, making it highly promising for the next‐generation anti‐counterfeiting of currency and passports.
Magnetic Silica‐Coated Fluorescent Microspheres (MagSiGlow) for Simultaneous Detection of Tumor‐Associated Proteins
Authors: Halabi Elias A. , Gessner Isabel , Yang Katherine S. , Kim Jae‐Jun , Jana Rupsa , Peterson Hannah M. , Spitzberg Joshua D. , Weissleder Ralph 
Published: April 2024

AbstractMultiplexed bead assays for solution‐phase biosensing often encounter cross‐over reactions during signal amplification steps, leading to unwanted false positive and high background signals. Current solutions involve complex custom‐designed and costly equipment, limiting their application in simple laboratory setup. In this study, we introduce a straightforward protocol to adapt a multiplexed single‐bead assay to standard fluorescence imaging plates, enabling the simultaneous analysis of thousands of reactions per plate. This approach focuses on the design and synthesis of bright fluorescent and magnetic microspheres (MagSiGlow) with multiple fluorescent wavelengths serving as unique detection markers. The imaging‐based, single‐bead assay, combined with a scripted algorithm, allows the detection, segmentation, and co‐localization on average of 7500 microspheres per field of view across five imaging channels in less than one second. We demonstrate the effectiveness of this method with remarkable sensitivity at low protein detection limits (100 pg/mL). This technique showed over 85 % reduction in signal cross‐over to the solution‐based method after the concurrent detection of tumor‐associated protein biomarkers. This approach holds the promise of substantially enhancing high throughput biosensing for multiple targets, seamlessly integrating with rapid image analysis algorithms.
Layer‐Controllable “2.5D” DNA Origami Crystals Synthesized by a Hierarchical Assembly Strategy
Authors: Xie Xiaolin , Ji Min , Yan Xuehui , Yu Yifan , Wang Yong , Ma Ningning , Xing Hang , Tian Ye 
Published: April 2024

AbstractThe finite periodic arrangement of functional nanomaterials on the two‐dimensional scale enables the integration and enhancement of individual properties, making them an important research topic in the field of tuneable nanodevices. Although layer‐controllable lattices such as graphene have been successfully synthesized, achieving similar control over colloidal nanoparticles remains a challenge. DNA origami technology has achieved remarkable breakthroughs in programmed nanoparticle assembly. Based on this technology, we proposed a hierarchical assembly strategy to construct a universal DNA origami platform with customized layer properties, which we called 2.5‐dimensional (2.5D) DNA origami crystals. Methodologically, this strategy divides the assembly procedure into two steps: 1) array synthesis, and 2) lattice synthesis, which means that the layer properties, including layer number, interlayer distance, and surface morphology, can be flexibly customized based on the independent designs in each step. In practice, these synthesized 2.5D crystals not only pioneer the expansion of the DNA origami crystal library to a wider range of dimensions, but also highlight the technological potential for templating 2.5D colloidal nanomaterial lattices.