bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Structure and Stereochemistry of Quinoline Alkaloids from Choisya ternata.
Authors: Boyd Derek R. , Sharma Narain D. , Loke Pui L. , Malone John F. , McRoberts W. Colin , Hamilton John T. G. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Bifunctional Acyclic Nucleoside Phosphonates. Part 2. Symmetrical 2‐{[Bis(phosphono)methoxy]methyl}ethyl Derivatives of Purines and Pyrimidines.
Authors: Vrbkova Silvie , Dracinsky Martin , Holy Antonin 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of the Germination Stimulant 3‐Methyl‐2H‐furo[2,3‐c]pyran‐2‐one and Analogous Compounds from Carbohydrates.
Authors: Goddard‐Borger Ethan D. , Ghisalberti Emilio L. , Stick Robert V. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel Synthesis of Naturally Occurring Pulvinones: A Heck Coupling, Transesterification, and Dieckmann Condensation Strategy.
Authors: Bernier David , Brueckner Reinhard 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Kehokorins and Trichiols from the Myxomycete Trichia favoginea.
Authors: Watanabe Kousuke , Ohtsuki Takashi , Yamamoto Yukinori , Ishibashi Masami 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Large Descriptor Set and a Probabilistic Kernel‐Based Classifier Significantly Improve Druglikeness Classification.
Authors: Li Qingliang , Bender Andreas , Pei Jianfeng , Lai Luhua 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Design of Inhibitors of the MurF Enzyme of Streptococcus pneumoniae Using Docking, 3D‐QSAR, and de Novo Design.
Authors: Khedkar Santosh A. , Malde Alpeshkumar K. , Coutinho Evans C. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Advances on the Nanostructuration of Magnetic Molecules on Surfaces: The Case of Single‐Molecule Magnets (SMM)
Authors: Gomez‐Segura Jordi , Veciana Jaume , Ruiz‐Molina Daniel 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Usability levels for sparse linear algebra components
Authors: Sosonkina M. , Liu F. , Bramley R. 
Published: November 2007

AbstractSparse matrix computations are ubiquitous in high‐performance computing applications and often are their most computationally intensive part. In particular, efficient solution of large‐scale linear systems may drastically improve the overall application performance. Thus, the choice and implementation of the linear system solver are of paramount importance. It is difficult, however, to navigate through a multitude of available solver packages and to tune their performance to the problem at hand, mainly because of the plethora of interfaces, each requiring application adaptations to match the specifics of solver packages. For example, different ways of setting parameters and a variety of sparse matrix formats hinder smooth interactions of sparse matrix computations with user applications. In this paper, interfaces designed for components that encapsulate sparse matrix computations are discussed in the light of their matching with application usability requirements. Consequently, we distinguish three levels of interfaces, high, medium, and low, corresponding to the degree of user involvement in the linear system solution process and in sparse matrix manipulations. We demonstrate when each interface design choice is applicable and how it may be used to further users' scientific goals. Component computational overheads caused by various design choices are also examined, ranging from low level, for matrix manipulation components, to high level, in which a single component contains the entire linear system solver. Published in 2007 by John Wiley & Sons, Ltd.
Meteor: a middleware infrastructure for content‐based decoupled interactions in pervasive grid environments
Authors: Jiang Nanyan , Quiroz Andres , Schmidt Cristina , Parashar Manish 
Published: November 2007

AbstractEmerging pervasive information and computational environments require a content‐based middleware infrastructure that is scalable, self‐managing, and asynchronous. In this paper, we propose associative rendezvous (AR) as a paradigm for content‐based decoupled interactions for pervasive grid applications. We also present Meteor, a content‐based middleware infrastructure to support AR interactions. The design, implementation, and experimental evaluation of Meteor are presented. Evaluations include experiments using deployments on a local area network, the wireless ORBIT testbed at Rutgers University, and the PlanetLab wide‐area testbed, as well as simulations. Evaluation results demonstrate the scalability, effectiveness, and performance of Meteor to support pervasive grid applications. Copyright © 2007 John Wiley & Sons, Ltd.
Using MOS current dividers for linearization of programmable gain amplifiers
Authors: Sanz M. Teresa , Celma Santiago , Calvo Belén 
Published: November 2007

AbstractTwo highly linear, digitally programmable gain amplifiers are presented and compared in terms of linearity, frequency, area and power consumption. High linearity and wide gain tuning range with moderate area consumption are the main benefits of both configurations. Furthermore, constant bandwidth is achieved by means of switched compensation capacitor arrays. Three‐bit prototypes were integrated in a 0.35 µm–3.3 V CMOS process with 2.5 V supply voltage. Experimental distortion levels are better than −68 dB for 1 MHz and 1 Vp−poutput signals in both configurations; hence, the suitability of the linearization technique based on MOS current dividers is shown. Copyright © 2007 John Wiley & Sons, Ltd.
Prospective associations between depressive symptoms and eating disorder symptoms among adolescent girls
Authors: Marmorstein Naomi R. , von Ranson Kristin M. , Iacono William G. , Malone Stephen M. 
Published: November 2007

AbstractObjective:Although eating disorders are frequently associated with depression, evidence regarding which problem predicts the other is conflicting, and little research has addressed the developmental course of this relation. This study examined longitudinal associations between depression and eating pathology across adolescence.Method:Participants were 754 girls participating in the community‐based Minnesota Twin Family Study. Depressive symptoms and eating pathology were assessed at approximately ages 11, 14, and 17.Results:As expected, substantial continuity in both eating pathology and depressive symptoms occurred across time. Analysis of cross‐lag paths controlling for earlier levels of symptoms indicated that overall levels of eating pathology predicted later depressive symptoms from 11 to 14 and from 14 to 17.Conclusion:Adolescent girls with high levels of eating‐related pathology appear to be at risk for later depression. © 2007 by Wiley Periodicals, Inc. Int J Eat Disord 2008
Understanding how parents cope with living with someone with anorexia nervosa: Modelling the factors that are associated with carer distress
Authors: Kyriacou Olivia , Treasure Janet , Schmidt Ulrike 
Published: November 2007

AbstractObjective:Caring for a person with anorexia nervosa (AN) has been associated with psychological distress and poor life quality of carers. Addressing carers' needs may impact on prognostic outcome. The aim was to explore and model factors associated with distress in parents of people with AN (N = 151).Method:A cross‐sectional design was used to assess caregiving strains (Pearlin Stress Scales) and psychological distress (Hospital Anxiety and Depression Scale).Results:Over 70% of carers (N = 107) scored at or above the suggestive threshold (score ≥ 8) for anxiety, and 38% (N = 54) for depression. Over 50% of carers (N = 78) scored at or above the clinical threshold (score ≥ 11) for anxiety, and 13% (N = 20) for depression. A model of carer distress after multiple regression analyses showed three significant associated variables. In order of significance, self‐related strains, carer sex, and interpersonal strains accounted for 41% of the variance, (F(3, 112) = 29.85, p < .001).Conclusion:Interventions aimed at improving outcome in AN may need to focus on reducing caregiving strains and carers' distress, particularly of mothers. © 2007 by Wiley Periodicals, Inc. Int J Eat Disord 2008
Yttrium, Lanthanide and Mixed Y‐Ln Vanadates Prepared from Molecular Precursors Based on EDTA
Authors: Deligne Nicolas , Gonze Vanessa , Bayot Daisy , Devillers Michel 
Published: November 2007

AbstractYttrium(III) and lanthanide(III) vanadates corresponding to the general formula AVO4 (A = Y, Pr, Sm, Eu, Gd, Dy, Er) were prepared by a nonconventional soft chemistry route in which coordination compounds of the different elements to be incorporated were used as molecular precursors. In this case, EDTA‐based yttrium(III), lanthanide(III) and vanadium(V) complexes were synthesised, characterised and used as precursors for the preparation of zircon‐type AVO4 materials at a moderate temperature of 800 °C, as evidenced by XRD and Raman analyses. Solid solutions such as Y1–xPrxVO4 and Y1–xGdxVO4 were also obtained. Linear correlations between chemical compositions and lattice parameters or Raman shifts were observed. SEM was used to characterise the particle size and morphology. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Biogenesis and Biomimetic Chemistry: Can Complex Natural Products Be Assembled Spontaneously?
Authors: Gravel Edmond , Poupon Erwan 
Published: November 2007

AbstractWith selected examples, we try to demonstrate that complex structures of natural products can be generated with surprising spontaneity. In such cases it appears that molecular complexity might emerge with minimal (if any) enzymatic assistance, through self‐construction mechanisms. Rearrangements of linear molecules, light‐induced reactions, dimerizations and multi‐component reactions could explain the formation of secondary metabolites through the intrinsic reactivity of their precursors. A few examples, amongst the most significant, are presented, along with efficient biomimetic syntheses that strengthen the hypotheses.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
One‐Pot Synthesis of Functionalized 3‐(Trifluoromethyl)phenols by [3+3] Cyclization of 1,3‐Bis(silyl enol ethers) with α,β‐Unsaturated Trifluoromethyl Ketones
Authors: Mamat Constantin , Pundt Thomas , Tam Dang T. H. , Klassen Renske , Reinke Helmut , Köckerling Martin , Langer Peter 
Published: November 2007

AbstractFunctionalized 3‐(trifluoromethyl)phenols were prepared by formal [3+3] cyclization of 1,3‐bis(silyl enol ethers) with readily available open‐chained and cyclic α,β‐unsaturated trifluoromethyl ketones. The reaction of 3,4‐dihydro‐5‐(trifluoroacetyl)‐2H‐pyran with 1,3‐bis(silyl enol ethers) resulted in a domino process to give new functionalized dihydropyrans. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Synthesis of Enantiopure (S)‐Indolylglycine by Organocatalyzed Friedel–Crafts Alkylation of Indole
Authors: Wanner Martin J. , Hauwert Peter , Schoemaker Hans E. , de Gelder René , van Maarseveen Jan H. , Hiemstra Henk 
Published: November 2007

AbstractTritylsulfenyl‐ and 2‐nitrophenylsulfenyl‐substituted glyoxyl imines were used in chiral phosphoric acid catalyzedFriedel–Crafts (FC) reactions with indole. High yields and ee values ranging from 86 % for Nps‐protected (S)‐indolylglycine to 88 % for Trs‐protected (R)‐indolylglycine were obtained. On a preparative scale, a FC product with 99.5 % ee and 71 % yield was readily obtained by crystallization of the reaction mixture. Removal of the Nps protecting group under mild acidic conditions did not affect the stereochemical integrity of the α‐carbon atom and (S)‐indolylglycine was afforded in ≥98 % ee.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Bacterial characterization using protein profiling in a microchip separations platform
Authors: Pizarro Shelly A. , Lane Pamela , Lane Todd W. , Cruz Evelyn , Haroldsen Brent , VanderNoot Victoria A. 
Published: November 2007

AbstractA rapid microanalytical protein‐based approach to bacterial characterization is presented. Chip gel electrophoresis (CGE) coupled with LIF detection was used to analyze lysates from different bacterial cell lines to obtain signature profiles of the soluble protein composition. The study includes Escherichia coli, Bacillus subtilis, and Bacillus anthracis (Δ Sterne strain) vegetative cells as well as endospores formed from the latter two species as model organisms to demonstrate the method. A unified protein preparation protocol was developed for both cell types to streamline the benchtop process and aid future automation. Cells and spores were lysed and proteins solubilized using a combination of thermal and chemical lysis methods. Reducing agents, necessary to solubilize spore proteins, were eliminated using a small‐scale rapid size‐exclusion chromatography step to eliminate interference with down‐stream protein labeling. This approach was found to be compatible with nonspore cells (i.e., vegetative cells) as well, not adversely impacting the protein signatures. Data are presented demonstrating distinct CGE protein signatures for our model organisms, suggesting the potential for discrimination of organisms on the basis of empirical protein patterns. The goal of this work is to develop a fast and field‐portable method for characterizing bacteria via their proteomes.
Comparative study of floating and dynamic injection modes in electrokinetic separative microsystems
Authors: Blas Maximilien , Delaunay Nathalie , Rocca Jean‐Louis 
Published: November 2007

AbstractMiniaturization of analytical instruments has attracted a wide interest in analytical chemistry over the past decade because of the advantages of reduced reagent consumption, better analytical performance, and shorter analysis time. The widespread interest in this field has resulted in efforts to develop chips. For chips involving separation, injection is a key step to achieve efficient and sensitive analysis. This work presents a comparative study of two electrokinetic injection modes in chips: the floating, which has been mainly used up to now, and the dynamic. This study was done with a crossjunction, either with numerical simulations or with experiments. Experiments were carried out with homemade PDMS–glass microsystems involving zonal electrophoresis analysis of five derivatized amino acids. Injected amount, reproducibility, separation efficiency, and analyte discrimination were evaluated and discussed. The experimental results were successfully correlated with numerical simulations. It appeared that the dynamic injection mode is much more appropriate than the floating mode as it is faster (reduction by a factor 2 of the total analysis time here), more reproducible (RSD of peak areas equal to 1.3% (n = 4) instead of 10% (n = 4)), and leads to more efficient separation (about 20% with 3 cm separation channel length) for the same injected amount, whatever the amount, because the sample plug is less dispersed.
Spatially addressable protein array: ssDNA‐directed assembly for antibody microarray
Authors: Ng Jin Kiat , Ajikumar Parayil Kumaran , Tang Yew Chung , Lee Jim Yang , Stephanopoulos Gregory , Too Heng‐Phon 
Published: November 2007

AbstractProtein microarray offers a means for high‐throughput profiling of cellular proteins to provide insights into the mechanisms of biological processes. This study describes the design and fabrication of a robust platform, spatially addressable protein array (SAPA), by exploring the specificity of ssDNA hybridization for self‐assembly of semi‐synthetic ssDNA‐antibody conjugates which capture antigens from complex biological samples. This approach does not involve the direct immobilization of antibodies nor antigen, but instead captures the target antigens in the solution phase followed by self‐directed assembly of the complex onto the surface. In an effort to optimize the platform, the effects of surface chemistry, nonspecific protein adsorption, facile preparation, and purification of ssDNA‐conjugated antibody and capture of the antigen from a complex biological sample such as cell lysate were examined. This platform allowed antigen detection in cell lysate with high sensitivity (1 pM). The method described herein can be extended to the high‐throughput detection of other interacting molecules in solution phase and their subsequent assembly onto any substrate.
A simplified method for capillary embedment into microfluidic devices – exemplified by sol–gel‐based preconcentration
Authors: Thorslund Sara , Johannesson Nina , Nikolajeff Fredrik , Bergquist Jonas 
Published: November 2007

AbstractWe here describe an alternative method of embedding functionalized capillaries into microdevices fabricated in PDMS. The capillaries have square‐shaped outer dimensions and fit into elastic PDMS channel networks of similar dimensions. By modifying the capillary off‐chip, the technique makes it possible to integrate a new chip function without risking contamination of already existing chemically patterned areas because of new reagent solutions. Leak‐free insertion of these capillaries has earlier been reported, where a thin layer of uncured PDMS bonded the capillary to the microchannel and the lid structure. In this new approach, oxygen plasma is used to bond the square capillary to the PDMS, eliminating the risk of clogging the microsystem with uncured prepolymer. The new embedding technique was exemplified and evaluated by inserting a square capillary piece containing monolithic sol–gel for sample preconcentration application. The assembled microdevice was run with mass spectrometric detection, showing that peptides were preconcentrated without leakage from either the sol–gel itself or around the inserted capillary. Repeated preconcentration runs showed migration times better than 3% for all peptides. We believe that the presented microchip assembling technique greatly simplifies the insertion of functionalized capillary pieces, e.g., an initial preconcentrator to a PDMS device containing other downstream modules.
Temperature gradient focusing in a PDMS/glass hybrid microfluidic chip
Authors: Matsui Takuya , Franzke Joachim , Manz Andreas , Janasek Dirk 
Published: November 2007

AbstractThis paper reports the application of temperature gradient focusing (TGF) in a PDMS/glass hybrid microfluidic chip. With TGF, by the combination of a temperature gradient along a microchannel, an applied electric field, and a buffer with a temperature‐dependent ionic strength, analytes are focused by balancing their electrophoretic velocities against the bulk velocity of the buffer containing the analytes. In this work, Oregon Green 488 carboxylic acid was concentrated approximately 30 times as high as the initial concentration in 45 s at moderate electric strength of 70 V/cm and a temperature gradient of 55°C across the PDMS/glass hybrid microfluidic chip with a 1 cm long capillary.
Turn‐induced isotachophoretic focusing in microfluidic channels
Authors: Paschkewitz John S. , Molho Joshua I. , Xu Hui , Bharadwaj Rajiv , Park C. Charles 
Published: November 2007

AbstractMultifunctional microfluidic platforms that use ITP for sample stacking require the use of serpentine channels. When ITP is carried out in serpentine passages, the sample band shows dramatically different behavior than that observed in conventional on‐chip CE. The band skew, defined as the distance between the leading and trailing edge of the band, is reduced and the sample is focused on the outside wall of the turn. This effect is explained using a simplified analytical model for the infinite Peclet number limit and the predicted trends are compared to full numerical simulations and experimental measurements. The outward focusing is driven by a wall‐normal electric field that results from the skewed leading buffer‐trailing buffer (LB‐TB) interface. The results indicate that the degree of outward focusing is controlled by the ratio of the LB and TB conductivities, the ratio of the channel width to turn radius, and the Peclet number. Increasing the band skew, which shows a complex dependence on the nondimensional parameters, maximizes the outward focusing effect.
Monitoring of enzymatic reactions using conventional and on‐chip capillary electrophoresis with contactless conductivity detection
Authors: Schuchert‐Shi Aiping , Kubáň Pavel , Hauser Peter C. 
Published: November 2007

AbstractThe use of CE with contactless conductivity detection was evaluated for monitoring enzymatic reactions. The nonionic species ethanol, glucose, ethyl acetate, and ethyl butyrate were made accessible for analysis by CE via charged products or by‐products obtained in enzymatic conversions using hexokinase, glucose oxidase, alcohol dehydrogenase, and esterase. Two of the reactions, namely the conversion of glucose with glucose oxidase and that of ethylacetate with esterase, were also successfully demonstrated on a microchip device. Quantification for ethyl acetate, taken as an example, was found possible with a detection limit of approximately 7 μM.
A microfluidic device for parallel 3‐D cell cultures in asymmetric environments
Authors: Frisk Thomas , Rydholm Susanna , Liebmann Thomas , Svahn Helene Andersson , Stemme Göran , Brismar Hjalmar 
Published: November 2007

AbstractWe demonstrate a concept for how a miniaturized 3‐D cell culture in biological extracellular matrix (ECM) or synthetic gels bridges the gap between organ‐tissue culture and traditional 2‐D cultures. A microfluidic device for 3‐D cell culture including microgradient environments has been designed, fabricated, and successfully evaluated. In the presented system stable diffusion gradients can be generated by application of two parallel fluid flows with different composition against opposite sides of a gel plug with embedded cells. Culture for up to two weeks was performed showing cells still viable and proliferating. The cell tracer dye calcein was used to verify gradient formation as the fluorescence intensity in exposed cells was proportional to the position in the chamber. Cellular response to an applied stimulus was demonstrated by use of an adenosine triphosphate gradient where the onset of a stimulated intracellular calcium release also depended on cell position.