bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autophagy-mediated ferroptosis is involved in development of severe acute pancreatitis
Authors: li hongyao , wu ding , zhang haidan , liu shixian , zhen jiahui , yan yufen , li peiwu 
Published: March 2024

Abstract
Ferroptosis is a newly recognized form of regulatory cell death characterized by severe lipid peroxidation triggered by iron overload and the production of reactive oxygen species (ROS). However, the role of ferroptosis in severe acute pancreatitis has not been fully elucidated. Our study found that ferroptosis occurs during the development of severe acute pancreatitis, such as iron and lipid peroxidation in pancreatic tissues, decreased levels of reduced glutathione peroxidase 4 (GPX 4) and glutathione (GSH), and increased MDA and significant mitochondrial damage. In addition,ferroptosis related proteins such as GPX4, SLC7A11 and FTH1 were significantly decreased. Next, the pathogenesis of ferroptosis in SAP was studied. First, treatment with the ferroptosis inhibitor Fer-1 significantly alleviated ferroptosis in SAP. Interestingly, autophagy occurs during the pathogenesis of SAP, and autophagy promotes the occurrence of ferroptosis in SAP. Moreover, 3-methyladenine (3-MA) inhibition of autophagy can significantly reduce iron overload and ferroptosis in SAP. Taken together, our results suggest that ferroptosis is a novel pathogenesis of SAP and is dependent on autophagy. This study provides a new theoretical basis for the study of SAP.
Unlocking Ultra-High Holographic Information Capacity through Nonorthogonal Polarization Multiplexing
Authors: Li Guanhai , Wang Jie , Chen Jin , Yu Feilong , Chen Rongsheng , Wang Jiuxu , Zhao Zengyue , Li Xuenan , Xing Huaizhong , Chen Xiaoshuang , Lu Wei 
Published: March 2024

Abstract

Contemporary studies in polarization multiplexing are hindered by the intrinsic orthogonality constraints of polarization states, which restrict the scope of multiplexing channels and their practical applications. This research transcends these barriers by introducing an innovative nonorthogonal polarization-basis multiplexing approach. Utilizing spatially varied local polarization states within metaatoms, we successfully reconstruct globally nonorthogonal channels that exhibit minimal crosstalk. This method not only facilitates the generation of free-vector holograms, achieving complete degrees-of-freedom in three nonorthogonal channels with ultra-low energy leakage, but it also significantly enhances the dimensions of the Jones matrix, expanding it to a groundbreaking 10×10 scale. The fusion of a controllable eigen-polarization engineering mechanism with a vectorial optical diffraction neural network culminates in the experimental creation of 55 intricate holographic patterns across these expanded channels. This advancement represents a profound shift in the field of polarization multiplexing, unlocking unprecedented opportunities in advanced holography and quantum encryption, among other applications.
Causal Implications of 731 Immune Cell Types in Atrial Fibrillation: Bidirectional Two-Sample Mendelian Randomization Analysis
Authors: li han , Zhong Guo-Qiang 
Published: March 2024

Abstract

Background
The pathogenesis of atrial fibrillation (AF) is still unclear, and our aim was to understand whether immune cells play a causal role in AF.
Methods
In this study, we conducted an exhaustive Mendelian Randomization (MR) analysis leveraging publicly accessible genetic datasets to investigate the causal relationship between 731 immune cell counts and the risk of AF. Our primary analytical strategies encompassed Mendelian Randomization and sensitivity analyses, employing Inverse Variance Weighted (IVW) and Weighted Median approaches, to ascertain the causal linkage between the immune cell counts under examination and susceptibility to AF. This methodology facilitated a comprehensive evaluation of the potential genetic predispositions influencing AF risk through alterations in immune cell profiles, thereby contributing to a deeper understanding of the etiological mechanisms underlying AF.
Results
Following False Discovery Rate (FDR) adjustment, our findings revealed that AF does not exert a significant impact on immune cell counts. However, a significant association was observed between AF risk and two specific immune cell counts: IgD-CD38dim B cells (Odds Ratio [OR] = 1.049, 95% Confidence Interval [CI] = 1.024–1.075, P = 0.0001, PFDR = 0.039) and CD25 on IgD + CD38dim B cells (OR = 0.974, 95% CI = 0.962–0.986, P = 1.87E-05, PFDR = 0.012).
Conclusions
This study has unveiled a profound interconnection between immune cells and AF, thereby presenting novel therapeutic targets for the diagnosis and treatment of AF.
Deep Learning for Signal Detection in Non-orthogonal Multiple Access Orthogonal Time-Frequency Space
Authors: Yu Dan , Wu Zhaofeng , Zhang Haiyang , Li Huanze , Fu Sha 
Published: March 2024

Abstract
The Non-orthogonal Multiple Access Orthogonal Time-Frequency Space (NOMA-OTFS) modulation technique can address the multiuser communication challenges in high-mobility scenarios. To tackle the high model complexity in the downlink detection system for NOMA-OTFS modulation, this paper introduces a signal detection algorithm based on deep neural network technology. The use of deep learning techniques enhances the receiver model, reduces model complexity, and improves system efficiency. The algorithm’s stability, reliability, and scenario applicability are ensured through offline training of symbol-level datasets. Simulation results indicate that the proposed algorithm outperforms existing schemes in terms of Bit Error Rate (BER), demonstrating superior detection performance and robustness.
ROS-induced cytosolic release of mitochondrial PGAM5 accelerates colorectal cancer progression via MST3-mediated YAP activation
Authors: Yu Zhengquan , Wang Shiyang , Bi Wenxin , Xu Jiuzhi , Li Guilin , Pan Yuwei , Li Mengzhen , Wu Xi , Du Sujuan , Zhang Mingxin , Hou Liyuan , Liu Di , Yu Lu , Plikus Maksim , Song Moshi , Zhou Zhaocai , Lv Cong 
Published: March 2024

Abstract

Aberrant release of mitochondrial reactive oxygen species (mtROS) in response to cellular stress is well known to induce neoplastic transformation. However, the precise molecular mechanisms by which mtROS contribute to epithelial tumorigenesis remains only partially understood. Here, we show in colorectal cancer (CRC) models that upon sensing excessive mtROS, the phosphatase PGAM5, which normally localizes in the mitochondria, undergoes aberrant cleavage by presenilin-associated rhomboid-like protein (PARL), and becomes released into the cytoplasm. Cytosolic PGAM5 then directly binds to and dephosphorylates MST3 kinase; this in turn prevents STK25-mediated LATS1/2 phosphorylation, leading to YAP activation and CRC development. Importantly, depletion of MST3 reciprocally promotes accumulation of cytosolic PGAM5 by inducing mitochondrial damage. Taken together, these findings demonstrate that mtROS promotes CRC progression by activating YAP via a novel post-transcriptional positive feedback loop between PGAM5 and MST3, both of which can serve as new targets for the development of novel anti-colon cancer therapeutics.
Design of pulse current welding modes for flux-cored wire for additive manufacturing purpose
Authors: Zavdoveev Anatoliy , Rogante Massimo , Pozniakov Valeriy , Gaivoronskiy Aleksandr , Baudin Thierry , Denisenko Anatoliy , Zhdanov Sergiy , Krazhanovskyi Denys , Zhernosekov Anatoliy , Klochkov Illia , Maksimenko Andrey , Motrunich Sviatoslav , Bevz Vitaliy 
Published: March 2024

Abstract
This research presents the results of an experimental investigation based on experiment using flux-cored wire and solid wire with the same average current but different geometries were studied. The primary objective of this research is to explore and optimize welding modes for flux-cored wire, emphasizing the disparities in pulse current modes when compared to solid wire welding. It underscores the importance of reevaluating welding modes traditionally considered suitable for solid wires when working with flux-cored welding materials. To this end, the paper examines the application scope of flux-cored wires and highlights the necessity for such considerations. Previous research findings indicate that even when employing identical welding modes, specifically with respect to average welding current in the case of Pulse Current Gas Metal Arc Welding (PC-GMAW), the resulting weld formations can exhibit substantial variations. This paper contributes to understanding of the factors affecting weld quality and sets the algorithm for optimizing pulse current modes for flux-cored wire welding applications.
Are Urban residents seeking appropriate care for Malaria? Evidence from an exploratory qualitative study in two cities in Nigeria
Authors: Ogunwale Akintayo , Ajayi Ikeoluwapo , Bamgboye Eniola , Adamu Al-Mukhtar , Bello Musa , Olawuwo Morenikeji , Fagbamigbe Adeniyi , Akinyemi Joshua , Ozodiegwu Ifeoma 
Published: March 2024

Abstract

Background
Unplanned and rapid urbanization within Nigerian cities with the attendant environmental consequences may hinder malaria elimination goal. Presently, there are limited qualitative studies on malaria case management, treatment and care-seeking patterns by settlement type in urban areas in Nigeria. This study, investigated the malaria-related health seeking behaviours among different settlement types in Ibadan and Kano metropolises, Nigeria.
Methods
This qualitative study involved conduct of Nine Focus Group Discussion (FGD) sessions among community members and 20 Key Informant interviews (KII) with health and community stakeholders in each of the two metropolises. The participants were purposively drawn from three settlement types – formal, informal and urban slum. Pretested FGD and KII were used to collect data. Data were subjected to thematic content analysis.
Results
Government-owned health facility especially Primary Health Care (PHC) facility was a major place identified as where many community members prefer to seek care for suspected malaria infection. Reasons adduced included proximity of facilities and services affordability. A common viewpoint was that most community members in informal and slum communities in both metropolises often patronize Proprietary Patent Medicine Vendors (PPMVs) or drug sellers as the first point for treatment of suspected malaria infection. Adduced reasons were poverty, ignorance and non-availability of 24 hours services in PHC facilities. High cost of hospital bills, poor attitude of health workers, long waiting time and cultural beliefs were identified as key factors influencing community members’ decision not to seek care for suspected malaria infection in the hospital. It was noted that the rich prefer to seek treatment in private hospitals, while the poor usually visit PHCs or resort to other options like buying drugs from PPMVs or use herbal drugs.
Conclusion
The preference of many community members in both metropolises for government-owned health facilities as well as the commoner practice of seeking care from patent medicine vendors and herbal drug sellers among informal settlements and slums dwellers calls for public health interventions. Specifically, the provision of free or affordable malaria care in health facilities; and training of community stakeholders and non-formal care providers on appropriate malaria care and referral to hospital are recommended.
Mediating Role of Effusion-synovitis on Knee Pain Worsening Following Quadriceps Weakness: Data from the Osteoarthritis Initiative
Authors: Gong Ze , Ao Di , Li Tingni , Li Le 
Published: March 2024

Abstract
Objective
The cause of increased knee pain related to quadriceps weakness in knee osteoarthritis remains unclear. This study aimed to assess the impact of alterations in the effusion-synovitis, a special kind of nociceptive structure, on changes in knee pain associated with quadriceps weakness.
Methods
Based on the Osteoarthritis Initiative cohort, knees with comprehensive records of quadriceps strength, effusion-synovitis, and knee pain assessments at baseline, 12-month and 24-month intervals were included. Quadriceps strength was measured isometrically at baseline, while effusion-synovitis and knee pain were assessed at baseline, 12-month, and 24-month follow-ups. Mediation-effect models were utilized to quantify the extent to which changes in effusion-synovitis, induced by quadriceps weakness, could mediate the impact on the knee pain scale.
Results
The analysis involved 1377 knees of 1235 participants with both baseline and 12-month follow-up data (61.1% females, mean age of 61.7 years). Baseline quadriceps strength was significantly associated with knee pain changes over 12 and 24 months, while changes in effusion-synovitis were also directly associated with worsening knee pain at 12- and 24-month follow-ups. More importantly, effusion-synovitis changes mediated the association between baseline quadriceps strength and knee pain worsening over 12 and 24 months, with the mediating proportion of 17.72% and 10.31%, respectively. Additionally, this mediation association remained significant in the population with radiographic osteoarthritis during 12-month follow-up.
Conclusion
Effusion-synovitis mediates approximately one-fifth of the association between baseline quadriceps strength and knee pain changes, suggesting that interventions targeting effusion-synovitis could facilitate the treatment of quadriceps-associated knee pain.
Differences in intestinal barrier function between Tianhua mutton sheep and Gansu alpine fine wool sheep (Ovis aries)
Authors: Li Dengpan , Liu Zhanjing , Duan Xinming , Wang Chunhui , Li Qiao , Ma Youji 
Published: March 2024

Abstract

The purpose of this study was to investigate the difference of intestinal barrier function between Tianhua mutton sheep and Gansu alpine fine wool sheep by HE staining, VFA assay and 16S full-length sequencing. The results showed as follows: 1) Compared with Gansu alpine fine wool sheep, Tianhua mutton sheep showed significantly higher villus height, significantly lighter crypt depth and significantly higher ratio of villus to crypt in duodenum and ileum (P-value < 0.05). 2) In both duodenum and jejunum, the contents of acetic acid and total acid were significantly higher in Tianhua mutton sheep than in Gansu alpine fine wool sheep (P-value < 0.05). 3) The overall comparison of the intestinal tract revealed that the Ace index of Tianhua mutton sheep was significantly higher than that of Alpine fine wool sheep (P-value < 0.05). The intestinal flora was able to separate significantly between the two breeds. LEfSe analysis found that Clostridia, Christensenellaceae-R-7-group-bacterium-AC2043 was the high abundance differential species in Tianhua mutton sheep. 4)The dominant flora of the two fine wool sheep were different in the five intestinal segments, but the content of beneficial bacteria of Tianhua mutton sheep was generally higher than that of Gansu alpine fine wool sheep. It can be seen that the intestinal barrier of Tianhua mutton sheep is better than that of Gansu alpine fine wool sheep, and Tianhua mutton sheep has a stronger adaptation to the living conditions of alpine pasture.
Synthetic syntrophy: A platform technology for adenine nucleotide cross-feeding between metabolically active vesicles
Authors: Poolman Bert , Heinen Laura , King Martin , Kunji Edmund , Noort Marco van den 
Published: March 2024

Abstract

Living systems depend on a continuous input of energy for growth, replication, and information processing. Cells convert nutrients or light to form metabolic energy in the form of ion gradients and ATP. However, to install sustained fueling pathways in synthetic systems is challenging. Inspired by endosymbionts that rely on the host cell for their nutrients, we introduce the concept of cross-feeding between synthetic vesicles that can exchange ATP and ADP across their membranes. One population of vesicles produces and exports ATP, while a second population of vesicles takes up the ATP to fuel energy-consuming reactions. The produced ADP feeds back to the first vesicles. The vesicles are a new platform technology to fuel ATP-dependent processes in a sustained fashion, with wide applications in synthetic cells and nanoreactors. Fundamentally, the vesicles enable studying non-equilibrium processes in an energy-controlled environment and promote the development and understanding of constructing life-like metabolic systems.
Relations between Academic and Behavioral Adaptations: The Antecedent Effects of Executive Function
Authors: Cao Xiaojing , Yan Ni 
Published: March 2024

Abstract

Using a large sample (n = 1,178) from the National Institute of Child Health and Development Study of Early Child Care and Youth Development, the Random Intercept Cross-Lagged Panel Model was employed to unpack the trait and state aspects in the relations between children’s academic performance and externalizing/internalizing behaviors during primary school and examined the predictive role of early executive function. Results showed that state-level fluctuations in children’s behavioral problems predicted subsequent academic performance, and vice versa. However, at the beginning of primary school and early adolescence, positive reciprocal predictive relations were found between children's problem behaviors and academic performance. Moreover, children with more advanced early executive function were found to have better academic performance and fewer behavioral problems throughout primary school, supporting the antecedent role of early executive function. Therefore, future interventions should focus on improving primary school students' adjustment with developmental-sensitive designs.
GSCNN: A genomic selection convolutional neural network model based on SNP genotype and physical distance features and data augmentation strategy
Authors: Ji Lu , Hou Wei , Xiong Liwen , Zhou Heng , Liu Chunhai , Li Lanzhi , Yuan Zheming 
Published: March 2024

Abstract

Background
Genomic selection (GS) proves to be an effective method for augmenting plant and animal breeding efficiency. Deep learning displays remarkable flexibility and vast capacity for representation, enabling it to capture complex associations, and is deemed one of the most auspicious models for GS.
Methods
The present study proposed a deep-learning technique named genomic selection convolutional neural network (GSCNN) that introduces innovation in three aspects. GSCNN encodes adjacent single nucleotide polymorphisms (SNPs) using the genotypes and physical distance (PD) between SNPs, allowing more accurate determination of the complex associative relationships of SNPs. Secondly, we generate new samples by perturbing SNP sequences based on chromosomes to solve the data scarcity problem and improve the performance of the GS deep learning model. In addition, the GSCNN uses advanced deep learning techniques - Bidirectional Encoder Representation from Transformers (BERT) embedding and attention pooling - to interpret biosequence information.
Results
Compared to widely used GS models, such as genomic best linear unbiased prediction, reproducing kernel Hilbert space, Bayes B, Bayesian lasso, and deep learning genome-wide association study, the GSCNN demonstrated superior performance in six prediction tasks.
Conclusion
The GSCNN is a promising model for GS and provides a reference for applying deep learning to other life science fields.
Understanding Public Perceptions and Discussions on Fibromyalgia through Social Media: Cross-Sectional Infodemiology Study
Authors: Valades MT , Montero-Torres M , Lara-Abelenda FJ , Carabot F , Ortega MA , Álvarez-Mon M , Alvarez-Mon MA 
Published: March 2024

Abstract

Background: Fibromyalgia is a prevalent condition of unknown etiology, characterized by generalized chronic pain that leads to disability, and has significant direct and indirect costs. The objective of this study was to examine the content and key aspects of tweets pertaining to diseases associated with chronic pain.
Methods: We investigated tweets published between January 1, 2018, and December 31, 2022, by English and Spanish-speaking Twitter users, as well as generated retweets. Additionally, emotions were extracted from these tweets and their dissemination was analysed. Similarly, the topics that users most frequently address were compiled.
Results: In total, 72,874 tweets were analysed in both English (44,467) and Spanish (28,407). Paraplegia represented 23.3%, with 16,461 classifiable tweets, followed by headache and fibromyalgia, with 15,337 (21.7%) and 15,179 (21.5%) tweets, respectively. Multiple sclerosis generated 14,781 tweets (21%), while the lowest number of tweets was associated with neuropathy, totaling 8,830 tweets (12.5%). The findings revealed that the primary emotions extracted were "fear" and "sadness". Furthermore, the scope and impact of these tweets were investigated through the generated retweets, with those related to headaches being of the highest interest and having the greatest interaction among users.
Conclusions: Our findings contribute to understanding the role that social media plays in fostering public awareness of chronic pain and improving patients' comprehension and treatment. Moreover, these results are likely to be applicable to other countries whose languages were not covered in our study.
Association Between Dietary Factors and Psoriasis: A Mendelian randomization analysis
Authors: Zheng Yanzhi , Xue Zhilong , Liang Zhongyi , Jin Aning 
Published: March 2024

Abstract
The WHO recognizes psoriatic arthritis (PsA) as a severe non-communicable disease, with Europe having the highest prevalence worldwide, affecting around 6.4 million people. Though dietary factors are closely associated with psoriasis (PsO) in clinical studies, few researchers have explored this link through Mendelian randomization (MR). This investigation analyzes the causal association between psoriasis and dietary factors. This study used MR analysis with publicly available genome-wide association studies to uncover causal relationships. Causal inference and effect estimates were determined using the inverse variance weighted (IVW) method. Additionally, sensitivity analysis included weighted median and MR-Egger methods, with leave-one-out analysis to ensure reliability. It was found that bread intake was associated with increased psoriasis risk (OR: 1.008; 95% CI: 1.003–1.015; p = 0.004), while beef consumption (OR: 0.989; 95% CI: 0.979–0.999; p = 0.043), cooked vegetables (OR: 0.967; 95% CI: 0.936–0.999; p = 0.046), and pork (OR: 0.985; 95% CI: 0.973–0.997; p = 0.016) were protective against psoriasis. No causal link was observed between other dietary factors and psoriasis. Overall, the study found that bread intake increased psoriasis risk, while beef, cooked vegetables, and pork consumption reduced it. Other diets showed no causal association with psoriasis.