bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facing the Forest: European Travellers Crossing the Mucuri River Valley, Brazil, in the Nineteenth Century
Authors: Horta Duarte Regina 
Published: May 2007

Abstract
Between 1816 and 1859, some European travellers visited the Mucuri River Valley, part of the Brazilian territory where the Atlantic Forest once flourished. From the travellers' accounts, we discuss the conditions of exploration, and some aspects of the historical changes that took place in that territory. Their reports comprise a rich documentation for the debate that is still alive on varied interactions among human societies and transformations of the natural environment. The tropical forests remain a challenge to be faced.
Decisional Conflict and Decision Regret in Head and Neck Oncology
Authors: Heirman Anne Nadine , Arends Coralie Romé , de Jel Dominique Valérie Clarence , Dirven Richard , van der Molen Lisette , Halmos Gyorgy Bela , van den Brekel Michiel Wilhelmus Maria , Stuiver Martijn Matthias 
Published: March 2024

ImportanceHead and neck cancer (HNC) often requires treatment with a major impact on quality of life. Treatment decision-making is often challenging, as it involves balancing survival against the preservation of quality of life and choosing among treatments with comparable outcomes but variation in morbidity and adverse events; consequently, the potential for decisional conflict (DC) and decision regret (DR) is high.ObjectivesTo summarize the literature on DC and DR in HNC, to give an overview of its prevalence and extent, and to advise on clinical practice and future research.Data SourcesEmbase, Web of Science, MEDLINE, and PsycINFO were searched up to February 24, 2023, including all years of publication.Study SelectionEligible studies addressed DC and/or DR as primary or secondary outcomes with any instrument in HNC, except cutaneous tumors. Two mutually blinded researchers conducted screening and inclusion with support of an artificial intelligence assistant and conducted risk of bias (ROB) assessment.Data Extraction and SynthesisThe Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines were followed for data extraction. ROB assessments were done using Critical Appraisal Skills Programme (qualitative) and CLARITY (quantitative). Meta-analysis with a random-effects model was used to obtain pooled prevalence estimates for DC and DR when at least 4 sufficiently clinically homogeneous studies were available.Main Outcomes and MeasuresPrevalence of DC (qualitative, Decisional Conflict Scale, SURE questionnaire) and DR (qualitative, study-specific questionnaires, Decision Regret Scale, Shame and Stigma Scale).ResultsOverall, 28 studies were included, with 16 included in meta-analyses for DR prevalence. The pooled prevalence of clinically relevant DR above the cutoff score for validated questionnaires (11 studies; 2053 participants) was 71% (95% CI, 58%-82%; I2 = 94%), while for study-specific questionnaires (5 studies; 674 participants) it was 11% (95% CI, 5%-22%; I2 = 92%). Only 4 studies investigated DC, showing a prevalence of 22.6% to 47.5% above cutoff values. Derived overarching themes found in qualitative studies were preparation, shared decision-making roles, information, time pressure, stress of diagnosis, and consequences.Conclusions and RelevanceAlthough limited data on DC and DR were available, the studies performed indicated that DC and DR are highly prevalent issues in HNC. Results suggest that study-specific questionnaires underestimated DR. The findings underscore the rationale to improve counseling and shared decision-making for this patient population.
Are we aware of neural activity in primary visual cortex? A neuropsychological case study
Authors: Hauw Fabien , Sangaré Aude , Munoz‐Musat Esteban , Meyniel Claire , Di Donato Nina , Chokron Sylvie , Bozon Frédérique , Naccache Lionel 
Published: March 2024

AbstractObjectiveAccording to a seminal hypothesis stated by Crick and Koch in 1995, one is not aware of neural activity in primary visual cortex (V1) because this region lacks reciprocal connections with prefrontal cortex (PFC).MethodsWe provide here a neuropsychological illustration of this hypothesis in a patient with a very rare form of cortical blindness: ventral and dorsal cortical pathways were lesioned bilaterally while V1 areas were partially preserved.ResultsVisual stimuli escaped conscious perception but still activated V1 regions that were functionally disconnected from PFC.InterpretationThese results are consistent with the hypothesis of a causal role of PFC in visual awareness.
Design Rules for the Nano‐Bio Interface of Nanodiamonds: Implications for siRNA Vectorization
Authors: Kindermann Marek , Neburkova Jitka , Neuhoferova Eva , Majer Jan , Stejfova Miroslava , Benson Veronika , Cigler Petr 
Published: March 2024

AbstractThe enormous therapeutic potential of selective ribonucleic acid (RNA) interference has recently been manifested by the approval of several small interfering RNA (siRNA)‐based drugs. However, the efficacy of siRNA delivery is still limited, and an extensive search for alternative and highly effective delivery approaches is ongoing. With this aim, three generations of non‐viral vectors based on modified nanodiamonds (NDs) have been gradually developed in the past decade. They show great promise due to the negligible toxicity of the ND core. Here, a robust methodological approach is presented to enable the evaluation of new vector nanomaterials. Using a new type of third‐generation ND vector coated with a copolymer with tunable charge density, variables such as colloidal stability, surface electrostatic properties, the molecular composition of the copolymer, and the mode of complexation with siRNA are optimized. Using an innovative data processing strategy, the results are related to biological potency, toxicity, and cell proliferation. Finally, the optimized composition of a coating copolymer consisting of a cationic component, 2‐dimethylaminoethyl methacrylate, and an electroneutral biocompatible component, N‐(2‐hydroxypropyl) methacrylamide, is evaluated. The optimized NDs vectors are colloidally and biologically stable siRNA delivery tools with broad potential for RNA interference‐based therapeutics.
Self‐Healing Materials for 3D Printing
Authors: Andreu Alberto , Lee Haeseung , Kang Jiheong , Yoon Yong‐Jin 
Published: March 2024

AbstractAdditive manufacturing/3D printing is praised as revolutionary by many because it enables the decentralized and on‐demand manufacturing of complex shapes. With the ongoing rapid development and increased availability of these technologies, it has become crucial to develop novel materials with unique functionalities for 3D‐printed components. Advances in self‐healing materials have resulted in structures capable of recovering from physical damage through material remendability. By applying self‐healing solutions to 3D printing, researchers are attempting to overcome current barriers such as low mechanical properties, material waste, and printability issues, among others. This review summarizes the current state of research on self‐healing materials used for 3D printing and presents recent progress in the 3D printing of self‐healing components. The particular focus is on the use of intrinsic polymer self‐healing, which is prominent in the published literature. The self‐healing mechanisms of the proposed material systems as well as their composition are highlighted, and their intended application with respect to 3D printing is focused on. The scientific and technological challenges involved in the implementation of self‐healing materials and approaches and the potential functional 3D printing applications of these new materials are also discussed.
Excellent Energy Storage Performance of ZnO doped (Pb,La)(Zr,Sn,Ti)O3 Based Antiferroelectric Ceramics at an Ultra‐Low Sintering Temperature of 940 °C
Authors: Zhao Han , Xu Ran , Wang Meng Jiao , Wang Gang , Sun Hong Chen , Wang Xiao Zhi , Zhu Qing Shan , Wei Xiao Yong , Feng Yu Jun , Xu Zhuo 
Published: March 2024

Abstract(Pb,La)(Zr,Sn,Ti)O3‐based antiferroelectric ceramics have excellent energy storage performance(more than 90% efficiency), which make them have great application advantages in the field of ceramic capacitors. However, the sintering temperature of (Pb,La)(Zr,Sn,Ti)O3‐based antiferroelectric ceramics is generally above 1250 °C, which limits application as a material for ceramic capacitors. Cu inner electrode has a low co‐firing temperature and high conductivity and a low cost price, making it more competitive in the field of ceramic capacitor inner electrode. Therefore, the first step is to reduce the sintering temperature of (Pb,La)(Zr,Sn,Ti)O3‐based ceramics to below 1000 °C(co‐firing temperature with Cu inner electrode), which is the key and difficult point. In this paper, Pb0.94La0.02Sr0.04(Zr0.45Sn0.47Ti0.08)0.995O3(PLSZST) antiferroelectric ceramics are doped with ZnO, which effectively reduce the sintering temperature. Among them, PLSZST‐1 wt% ZnO is sintered at an ultra‐low sintering temperature (TSintering = 940 °C), which is 330 °C lower than that of PLSZST(TSintering = 1270 °C) without doping ZnO. At the same time, PLSZST‐1 wt%ZnO obtain a recoverable energy density of 4.26J cm−3 and an energy efficiency of 95.5% at 230 kV cm−1. The pulse discharge energy density (Wdis = 3.92 J cm−3) and discharge time (t0.9 = 351 ns) are obtained at 220 kV cm−1, and the current density (CD = 1338A cm−2) and power density (PD = 134MW cm−3) are obtained at 200 kV cm−1. The results provide a possible material basis for Cu internal electrode ceramic capacitors.
Zinc‐Coordinated Imidazole‐Based Ionic Liquid as Liquid Salt for All‐Temperature Aqueous Zinc‐Ion Batteries
Authors: Zhong Mingyang , Wang Yang , Xie Yihua , Yuan Shouyi , Ding Kai , Begin Elijah J. , Zhang Yingjie , Bao Junwei Lucas , Wang Yonggang 
Published: March 2024

AbstractOwing to the intrinsically high safety, low cost, natural abundance, and high energy density of Zn metal, aqueous Zn ion batteries (AZIBs) have become a promising candidate for large‐scale energy conversion and storage. However, the practical application of AZIBs is hampered by the severe Zn dendrites growth and the poor low‐temperature performance due to the elevated freezing point of aqueous electrolyte. Herein, the study proposes a new kind of room‐temperature liquid Zn salt, which is called Zn coordinated ionic liquid (i.e., (EMIM)5Zn(OTF)7), for all‐temperature AZIBs. The aqueous electrolyte containing 0.261 mol kg−1 (EMIM)5Zn(OTF)7 in Ethylene Glycol (EG) / H2O (6:4) exhibits ultralow freezing point below −100 °C. The liquid Zn salt and EG molecules not only modulate the solvation structure of Zn2+ ion, reducing the coordinated H2O in the first solvation sheath, but also suppresses the parasitic side reaction. As a proof of concept, Zn || Zn symmetric cells and Zn || PANI full cells with the designed electrolyte achieve improved cycling stability and can operate under wide temperature (from −40 to 60 °C). Even with high Zn utilization ratio of 40%, long cycle life over 70 times with capacity retention of 80% is achieved.
4D Printed Self‐Sustained Soft Crawling Machines Fueled by Constant Thermal Field
Authors: Ren Luquan , He Yulin , Wang Baofeng , Xu Jingyi , Wu Qian , Wang Zhenguo , Li Wangxuan , Ren Lei , Zhou Xueli , Liu Qingping , Li Bingqian , Song Zhengyi 
Published: March 2024

AbstractEnvironmentally fueled sustainable autonomous locomotion is an advanced intelligent behavior analogous to unconscious actions in biological organisms, such as heartbeat and peristalsis. In this study, a self‐sustaining oscillating soft robot is introduced with eccentric hinge structures inspired by the crawling locomotion of mollusks. A parameter‐encoded 4D printing method is utilized to pre‐program local strain of the eccentric hinge structure, and thus endows the soft robot with sustainable crawling motions under constant thermal field. Through the coupling design of substrate friction, eccentric hinge constitution, and the substrate temperature, the soft robot can achieve tunable crawling, rolling, and oscillating. Two applications, namely an optical chopper and a power generator are presented as proof of concepts. This work offers a viable solution for soft robots for applications in constrained environments such as the aerospace and medical fields.
A Biodegradable Piezoelectric Sensor for Real‐Time Evaluation of the Motor Function Recovery After Nerve Injury
Authors: Shan Yizhu , Wang Engui , Cui Xi , Xi Yuan , Ji Jianying , Yuan Junlin , Xu Lingling , Liu Zhuo , Li Zhou 
Published: March 2024

AbstractNerve injury can lead to defects in related motor functions. It is critical to achieve long‐term and convenient real‐time evaluation of motor function recovery status during nerve injury repair. In this study, an implantable PLLA/BTO piezoelectric sensor (PBPS) with good biodegradability and biocompatibility for real time evaluation of the motor function recovery after nerve injury is developed. PLLA fibers doped with BTO are employed as piezoelectric material in PBPS, which can convert the biomechanical signals generated by motion into electrical signals. PBPS can be implant simultaneously with commonly used tissue scaffolds for treatment in the rats with sciatic nerve injury. The linearity of the pressure and the output voltage of PBPS is ≈0.9445. For the evaluation effectiveness, as the treatment process progresses, the signals generated by PBPS exhibited good consistency with EMG signals, indicating effectively evaluation of the motor function. Moreover, the integration of PBPS and wireless module can break the limitations of time and space for sensing and realize wireless evaluation of motor function in rat. The implantable sensor based on PBPS may bring new ideas for the development of implantable bioelectronics.
Efficient Near‐Infrared Emitting Halide Scintillators with Mitigating External Light Crosstalk for Portable X‐Ray Imaging
Authors: Wang Chao , Xiao Jiawen , Ma Sai , Li Yanbin , Yan Zhengguang 
Published: March 2024

AbstractPortable X‐ray imaging technology plays a crucial role in enabling prompt diagnosis and treatment outdoors. Nevertheless, the persistent challenge of external optical signal crosstalk poses a significant bottleneck to its advancement. Herein, a solution utilizing near‐infrared (NIR) light to effectively mitigate optical crosstalk is proposed, thereby demonstrating the feasibility of portable X‐ray imaging even under ambient light. A series of rare earth ions doped Cs2AgxNa1‐xInyBi1‐yCl6 halide scintillators is reported, which possess bright broadband visible and NIR emissions. Taking Cs2Ag0.6Na0.4In0.95Bi0.05Cl6: 5%Tm as an example, it shows decent thermal quenching resistance, high PLQY up to 76.3%, and compelling light yield up to 33500 photons MeV−1. The highly efficient NIR emission is attributed to the energy transfer from the optimized host to lanthanide ions. A flexible scintillation film is prepared by mixing poly(dimethyl‐siloxane) with Cs2Ag0.6Na0.4In0.95Bi0.05Cl6: 5%Tm powder, realizing a low X‐ray detection limit of 55.2 nGyair/s and a high spatial resolution of 11.2 lp mm−1. Due to the efficient NIR emission, the scintillation film enables clear X‐ray imaging under bright LED illumination with the simple addition of filters, avoiding the necessity of a complex imaging apparatus. This work sheds light on NIR emissive scintillator for rapid outdoor response and portable X‐ray imaging.
High‐Scale 3D‐Bioprinting Platform for the Automated Production of Vascularized Organs‐on‐a‐Chip
Authors: Fritschen Anna , Lindner Nils , Scholpp Sebastian , Richthof Philipp , Dietz Jonas , Linke Philipp , Guttenberg Zeno , Blaeser Andreas 
Published: March 2024

Abstract3D bioprinting possesses the potential to revolutionize contemporary methodologies for fabricating tissue models employed in pharmaceutical research and experimental investigations. This is enhanced by combining bioprinting with advanced organs‐on‐a‐chip (OOCs), which includes a complex arrangement of multiple cell types representing organ‐specific cells, connective tissue, and vasculature. However, both OOCs and bioprinting so far demand a high degree of manual intervention, thereby impeding efficiency and inhibiting scalability to meet technological requirements. Through the combination of drop‐on‐demand bioprinting with robotic handling of microfluidic chips, a print procedure is achieved that is proficient in managing three distinct tissue models on a chip within only a minute, as well as capable of consecutively processing numerous OOCs without manual intervention. This process rests upon the development of a post‐printing sealable microfluidic chip, that is compatible with different types of 3D‐bioprinters and easily connected to a perfusion system. The capabilities of the automized bioprint process are showcased through the creation of a multicellular and vascularized liver carcinoma model on the chip. The process achieves full vascularization and stable microvascular network formation over 14 days of culture time, with pronounced spheroidal cell growth and albumin secretion of HepG2 serving as a representative cell model.
Revitalizing Oxygen Reduction Reactivity of Composite Oxide Electrodes via Electrochemically Deposited PrOx Nanocatalysts
Authors: Nam Seongwoo , Kim Jinwook , Kim Hyunseung , Ahn Sejong , Jeon SungHyun , Choi Yoonseok , Park Beom‐Kyeong , Jung WooChul 
Published: March 2024

AbstractSolid oxide fuel cells that operate at intermediate temperatures require efficient catalysts to enhance the inherently poor electrochemical activity of the composite electrodes. Here, a simple and practical electrochemical deposition method is presented for fabricating a PrOx overlayer on lanthanum strontium manganite–yttria‐stabilized zirconia (LSM–YSZ) composite electrodes. The method requires less than four minutes for completion and can be carried out under at ambient temperature and pressure. Crucially, the treatment significantly improves the electrode's performance without requiring heat treatment or other supplementary processes. The PrOx‐coated LSM–YSZ electrode exhibits an 89% decrease in polarization resistance at 650 °C (compared to an untreated electrode), maintaining a tenfold reduction after ≈400 h. Transmission line model analysis using impedance spectra confirms how PrOx coating improved the oxygen reduction reaction activity. Further, tests with anode‐supported single cells reveal an outstanding peak power density compared to those of other LSM–YSZ‐based cathodes (e.g., 418 mW cm−2 at 650 °C). Furthermore, it is demonstrated that multicomponent coating, such as (Pr,Ce)Ox, can also be obtained with this method. Overall, the observations offer a promising route for the development of high‐performance solid oxide fuel cells.
A Biomimetic “Salting Out—Alignment—Locking” Tactic to Design Strong and Tough Hydrogel
Authors: Sun Xia , Mao Yimin , Yu Zhengyang , Yang Pu , Jiang Feng 
Published: March 2024

AbstractRecently, hydrogel‐based soft materials have demonstrated huge potential in soft robotics, flexible electronics as well as artificial skins. Although various methods are developed to prepare tough and strong hydrogels, it is still challenging to simultaneously enhance the strength and toughness of hydrogels, especially for protein‐based hydrogels. Herein, a biomimetic “salting out—alignment—locking” tactic (SALT) is introduced for enhancing mechanical properties through the synergy of alignment and the salting out effect. As a typical example, tensile strength and modulus of initially brittle gelatin hydrogels increase 940 folds to 10.12 ± 0.50 MPa and 2830 folds to 34.26 ± 3.94 MPa, respectively, and the toughness increases up to 1785 folds to 14.28 ± 3.13 MJ m−3. The obtained strength and toughness hold records for the previously reported gelatin‐based hydrogel and are close to the tendons. It is further elucidated that the salting out effect engenders hydrophobic domains, while prestretching facilitates chain alignment, both synergistically contributing to the outstanding mechanical properties. It is noteworthy that the SALT demonstrates remarkable versatility across different salt types and polymer systems, thus opening up new avenues for engineering strong, tough, and stiff hydrogels.
Ultrasensitive and Multiple Biomarker Discrimination for Alzheimer's Disease via Plasmonic & Microfluidic Sensing Technologies
Authors: Zu Lijiao , Wang Xicheng , Liu Peng , Xie Jiwei , Zhang Xuejun , Liu Weiru , Li Zhencheng , Zhang Shiqing , Li Kaiwei , Giannetti Ambra , Bi Wei , Chiavaioli Francesco , Shi Lei , Guo Tuan 
Published: March 2024

AbstractAs the population ages, the worldwide prevalence of Alzheimer's disease (AD) as the most common dementia in the elderly is increasing dramatically. However, a long‐term challenge is to achieve rapid and accurate early diagnosis of AD by detecting hallmarks such as amyloid beta (Aβ42). Here, a multi‐channel microfluidic‐based plasmonic fiber‐optic biosensing platform is established for simultaneous detection and differentiation of multiple AD biomarkers. The platform is based on a gold‐coated, highly‐tilted fiber Bragg grating (TFBG) and a custom‐developed microfluidics. TFBG excites a high‐density, narrow‐cladding‐mode spectral comb that overlaps with the broad absorption of surface plasmons for high‐precision interrogation, enabling ultrasensitive monitoring of analytes. In situ detection and in‐parallel discrimination of different forms of Aβ42 in cerebrospinal fluid (CSF) are successfully demonstrated with a detection of limit in the range of ≈30–170 pg mL−1, which is one order of magnitude below the clinical cut‐off level in AD onset, providing high detection sensitivity for early diagnosis of AD. The integration of the TFBG sensor with multi‐channel microfluidics enables simultaneous detection of multiple biomarkers using sub‐µL sample volumes, as well as combining initial binding rate and real‐time response time to differentiate between multiple biomarkers in terms of binding kinetics. With the advantages of multi‐parameter, low consumption, and highly sensitive detection, the sensor represents an urgently needed potentials for large‐scale diagnosis of diseases at early stage.