bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vivo pilot study into superficial microcirculatory characteristics of colorectal adenomas using novel high-resolution magnifying endoscopy with blue laser imaging
Authors: Dong Hai-Bin , Chen Tao , Zhang Xiao-Fei , Ren Yu-Tang , Jiang Bo 
Published: April 2024

BACKGROUND
No studies have yet been conducted on changes in microcirculatory hemodynamics of colorectal adenomas in vivo under endoscopy. The microcirculation of the colorectal adenoma could be observed in vivo by a novel high-resolution magnification endoscopy with blue laser imaging (BLI), thus providing a new insight into the microcirculation of early colon tumors.
AIM
To observe the superficial microcirculation of colorectal adenomas using the novel magnifying colonoscope with BLI and quantitatively analyzed the changes in hemodynamic parameters.
METHODS
From October 2019 to January 2020, 11 patients were screened for colon adenomas with the novel high-resolution magnification endoscope with BLI. Video images were recorded and processed with Adobe Premiere, Adobe Photoshop and Image-pro Plus software. Four microcirculation parameters: Microcirculation vessel density (MVD), mean vessel width (MVW) with width standard deviation (WSD), and blood flow velocity (BFV), were calculated for adenomas and the surrounding normal mucosa.
RESULTS
A total of 16 adenomas were identified. Compared with the normal surrounding mucosa, the superficial vessel density in the adenomas was decreased (MVD: 0.95 ± 0.18 vs 1.17 ± 0.28 μm/μm2, P < 0.05). MVW (5.11 ± 1.19 vs 4.16 ± 0.76 μm, P < 0.05) and WSD (11.94 ± 3.44 vs 9.04 ± 3.74, P < 0.05) were both increased. BFV slowed in the adenomas (709.74 ± 213.28 vs 1256.51 ± 383.31 μm/s, P < 0.05).
CONCLUSION
The novel high-resolution magnification endoscope with BLI can be used for in vivo study of adenoma superficial microcirculation. Superficial vessel density was decreased, more irregular, with slower blood flow.
Role of second look endoscopy in endoscopic submucosal dissection and peptic ulcer bleeding: Meta-analysis of randomized controlled trials
Authors: Kogilathota Jagirdhar Gowthami Sai , Perez Jose Andres , Banga Akshat , Qasba Rakhtan K , Qasba Ruman K , Pattnaik Harsha , Hussain Muhammad , Bains Yatinder , Surani Salim 
Published: April 2024

BACKGROUND
Second-look endoscopy (SLE) to prevent recurrent bleeding in patients with peptic ulcer disease (PUD) and those undergoing endoscopic submucosal dissection (ESD) is routinely being performed. Conflicting evidence exists regarding efficacy, risk, benefit, and cost-effectiveness.
AIM
To identify the role and effectiveness of SLE in ESD and PUD, associated rebleeding and PUD-related outcomes like mortality, hospital length of stay, need for endoscopic or surgical intervention and blood transfusions.
METHODS
A systematic review of literature databases PubMed, Cochrane, and Embase was conducted from inception to January 5, 2023. Randomized controlled trials that compared patients with SLE to those who did not have SLE or evaluated the role of prophylactic hemostasis during SLE compared to other conservative interventions were included. The study was conducted per PRISMA guidelines, and the protocol was registered in PROSPERO (ID CRD42023427555:). RevMan was used to perform meta-analysis, and Mantel-Haenszel Odds ratio (OR) were generated using random effect models.
RESULTS
A total of twelve studies with 2687 patients were included in our systematic review and meta-analysis, of which 1074 patients underwent SLE after ESD and 1613 patients underwent SLE after PUD-related bleeding. In ESD, the rates of rebleeding were 7% in the SLE group compared to 4.4% in the non-SLE group with OR 1.65, 95% confidence intervals (CI) of 0.96 to 2.85; P = 0.07, whereas it was 11% in the SLE group compared to 13% in the non-SLE group with OR 0.8 95%CI: 0.50 to 1.29; P = 0.36. The mean difference in the blood transfusion rates in the SLE and no SLE group in PUD was OR 0.01, 95%CI: -0.22 to 0.25; P = 0.91. In SLE vs non-SLE groups with PUD, the OR for Endoscopic intervention was 0.29, 95%CI: 0.08 to 1.00; P = 0.05 while it was OR 2.03, 95%CI: 0.95 to 4.33; P = 0.07, for surgical intervention. The mean difference in the hospital length of stay was -3.57 d between the SLE and no SLE groups in PUD with 95%CI: -7.84 to 0.69; P = 0.10, denoting an average of approximately 3 fewer days of hospital stay among patients with PUD who underwent SLE. For mortality between SLE and non-SLE groups in PUD, the OR was 0.88, 95%CI: 0.45 to 1.72; P = 0.70.
CONCLUSION
SLE does not confer any benefit in preventing ESD and PUD-associated rebleeding. SLE also does not provide any significant improvement in mortality, need for interventions, or blood transfusions in PUD patients. SLE decreases the hospital length of stay on average by 3.5 d in PUD patients.
Piense en … MELANOMA NODULAR AMELANÓTICO
Authors: Boulet María Julia , Camardella Ileana Rosalía , Coletto Gianina Anabella 
Published: April 2024

Granuloma piógeno: proliferación vascular capilar benigna, asociada a irritantes locales, trauma, infección, malformaciones vasculares preexistentes o medicación.
Edad más frecuente: infancia y adultos jóvenes.
Melanoma nodular amelanótico: el melanoma nodular representa el 15-30% del total de los melanomas. La variante amelanótica se observa en el 2 al 8% de todos los melanomas, más frecuentemente en melanoma nodular. Edad y factores de riesgo: >50 años. Fototipo I, raza blanca, ausencia de nevos en el dorso.
Carcinoma de células de Merkel: neoplasia neuroendocrina rara y agresiva. Edad y factores de riesgo: 65 a 85 años, >sexo masculino. RUV, inmunosupresión y poliomavirus.
Elección múltiple: LESIONES HIPERPIGMENTADAS EN PIEL
Authors: Bazan Mariam Yisell , Gonella del Carril María de la Paz 
Published: April 2024

Niña de 9 años procedente de Las Talitas, Tucumán, con antecedentes personales de hipoacusia bilateral y obesidad, consultó por presentar una dermatosis localizada en el rostro y la región inguinal de 3 meses de evolución, sin síntomas acompañantes.
Al examen físico se observaban máculas amarronadas, localizadas en la región palpebral bilateral, peribucal e inguinal.
Se solicitaron estudios complementarios incluyendo laboratorio que no evidenció datos significativos. En la dermatoscopia de las lesiones cutáneas se observaron glóbulos finos de color amarronados de disposición lineal y biopsia de piel de región inguinal en cuyo estudio histopatológico con tinción HyE informó un infiltrado inflamatorio en banda, que borró la unión dermoepidérmica, la degeneración vacuolar de los queratinocitos basales, cuerpos de civatte y los abundantes melanófagos cargados de pigmento.
As vacinas para COVID-19 e suas tecnologias: potencial e perspectivas
Authors: Abreu Nunes Viviane , Santiago Chambergo Felipe , Apetito Akamatsu Milena , Lee Ho Paulo 
Published: April 2024

Até dezembro de 2020, havia mais de 200 vacinas candidatas para COVID-19 sendo desenvolvidas. Entre estas, pelo menos 52 já estão em fase de testes em humanos, enquanto outras, atualmente em fase I/II, devem entrar na fase III nos próximos meses.
Normalmente, muitas vacinas são avaliadas antes que qualquer uma seja considerada segura e eficaz. Assim, de todas as vacinas que são estudadas in vitro e em animais de laboratório, cerca de sete em cada 100 serão consideradas adequadas para início dos testes clínicos em humanos. Das vacinas que chegam aos ensaios clínicos, apenas uma em cinco é bem-sucedida. Ter muitas vacinas diferentes em desenvolvimento aumenta as chances de que haja uma ou mais bem-sucedidas e que se mostrem seguras e eficazes para as populações pretendidas.
Existem diferentes abordagens para se projetar uma vacina. Suas diferenças residem no fato de usarem um vírus (ou bactéria) inteiro(a) ou apenas as partes do organismo que ativam o sistema imunológico (proteína ou açúcar), ou o material genético que fornece as instruções para a produção de proteínas específicas, capazes de estimular a resposta imune. Atualmente, outra modalidade tem sido proposta: uma vacina baseada no uso de células apresentadoras de antígeno, por exemplo. Nesse artigo, iremos apresentar e discutir as principais plataformas de produção de vacinas contra a COVID-19, em especial, das vacinas que estão aprovadas para uso comercial.
Effectiveness of Comprehensive Environmental Support for Community-Dwelling Older Adults: A Single-Blind Randomized Controlled Trial
Authors: Yabuwaki Kenji , Shinohara Kazuya , Fujioka Akira , Inagaki Shigeaki , Hirao Kazuki 
Published: April 2024

Abstract
Importance: The importance of developing age-friendly environments is globally recognized. However, few clinical trials have comprehensively evaluated physical and social components of environments and examined the effects of offering support.
Objective: To clarify the effectiveness of occupational therapy–based comprehensive environmental support for community-dwelling older adults.
Design: A single-blind parallel-groups randomized controlled trial with blinded participants.
Setting: Eight community-based settings under the long-term-care insurance system in regional towns and cities throughout Japan.
Participants: Sixty older adults age ≥65 yr who were new users of adult day care or adult day health care and allocated by stratified block randomization on the basis of age.
Intervention: Comprehensive environmental support was provided to participants for 3 mo according to results on the Comprehensive Environmental Questionnaire for older adults (CEQ) to make improvements in environmental factors participants wanted to change to create a more satisfying life.
Outcomes and Measures: The primary outcome measure was the Japanese Medical Outcomes Study 36-Item Short-Form Health Survey (SF–36) score at 3 mo postrandomization. Additionally, scores on the Short-Form Six-Dimension utility index were calculated.
Results: The experimental group showed significant improvements in the SF–36’s Role/Social Component Summary (p = .005) and Role–Physical (p = .02), Role–Emotional (p = .01), and Mental Health (p = .05) domains, with moderate effect sizes. The number needed to treat was 3.46, showing statistical significance.
Conclusions and Relevance: Occupational therapy–based comprehensive environmental support based on CEQ scores was effective, resulting in moderate improvements in health-related quality of life among community-dwelling older adults.
Plain-Language Summary: Older adults experience a decline in physical and mental functions along with changes in social relationships. These problems make it challenging for older adults to perform valuable occupations, thus reducing their quality of life. This study demonstrated that occupational therapy based on the Comprehensive Environmental Questionnaire for older adults can improve health-related quality of life among community-dwelling older adults. Our findings pave the way for the development of an effective compensatory intervention model in occupational therapy practice.
Desafíos y alternativas para las exportaciones de cacao en el departamento de Santander años 2018-2022
Authors: Picón Peralta Sergio Iván , Ramírez Adarme Johanna Patricia , Sandoval Villamizar Dianey Yamile 
Published: April 2024

El mercado internacional ha experimentado una creciente incertidumbre debido a los efectos de la postpandemia, lo que ha afectado las exportaciones incluyendo los productos agrícolas. Sin embargo, con el talento, la recursividad y la creatividad de la sociedad nacional colombiana, estos productos han logrado triunfar en el extranjero. Las prohibiciones de viajes y los suspensiones de fronteras han obstaculizado el flujo de mercancías, la demanda global ha disminuido y la incertidumbre en los mercados ha aumentado como resultado de la pandemia. Además, la disponibilidad de empleos en Santander también se ha visto afectada, lo cual puede impactar la fabricación y el comercio internacional de varios productos de los sectores agrícolas y manufactureros. Las sociedades que se internacionalizan y se inician hacia nuevos mercados que pueden ser más competitivas y experimentar un crecimiento sostenido. En este sentido, el documento destaca la importancia de comprender los indicadores que afectan las exportaciones en el departamento de Santander, con la finalidad de identificar estrategias para mejorar los resultados. Para este fin, se realizó una revisión bibliográfica analizando los hallazgos relacionados con las acciones tomadas en el departamento para el fortalecimiento competitivo y sostenible de la producción de cacao, producto insigne de la región, para posteriormente utilizando la matriz DOFA y la consulta de cifras estadísticas del año 2019 al 2022, lo cual permitió generar estrategias de fortalecimiento para el sector exportador. Estas herramientas ayudan a analizar el comercio internacional en los últimos cuatro años, proponiendo información para estimular el desarrollo y la participación efectiva de las compañías, resaltando los beneficios y dificultades de la región, los primordiales productos de exportación, la diversificación de los productos, los beneficios de los principales Tratados de Libre Comercio. En conclusión, este articulo busca ofrecer una visión integral de las perspectivas de exportaciones considerando aspectos políticos, sociales, tecnológicos y comerciales, proporcionando recomendaciones que permitan aumentar la posición competitiva en el mercado y aumentar las exportaciones a diferentes destinos.
Estudios organizacionales para mejorar la competitividad empresarial en Bucaramanga
Authors: Sandoval-Villamizar Dianey Yamile , Picón Peralta Sergio Iván , Cala Amaya Myriam Mercedes 
Published: April 2024

La globalización de los mercados de los sectores industriales y de servicios ha sido de gran importancia a nivel internacional y nacional dado que contribuye al crecimiento económico, generación de empleo y dinamizador de la economía, es por ello que cada vez las empresas deben adaptar sus procesos, productos a las nuevas tendencias del mercado y de los consumidores. En las Ciencias sociales, el Desarrollo Organizacional (DO) es un campo dedicado a comprender y facilitar los procesos de cambio en las organizaciones, así como la gestión y cultura. La siguiente investigación tiene como objetivo generar estrategias empresariales en algunas empresas de Bucaramanga, para mejorar procesos para hacerlas más competitivas, La investigación es de carácter exploratoria, orientada a analizar variables internas y externas de 30 empresas en Bucaramanga mediante el análisis DOFA para generar estrategias y hacer una propuesta de mejora. se realizaron tres fases: La primera fase, en la que se efectuó el diagnóstico de factores internos y externos para realizar una matriz DOFA, La segunda fase, se determinó estrategias Ofensivas, defensivas, de reorientación y de supervivencia y la tercera fase, correspondió a la propuesta de mejoramiento del área de la empresa con mayor problemática. Los resultados obtenidos fueron mejorar en algunas empresas de la planeación estratégica, implementación de plan de marketing, uso de una herramienta de CRM para poder fidelizar y tener un servicio posventa adecuado y eficiente, propuesta mejora de la comunicación interna, capacitación a los colaboradores, entre otras.
Спорт, политика и СМИ в контексте современных геополитических процессов
Authors: Полонский Андрей Васильевич , Боева Янка Красимирова 
Published: April 2024

Глобальным явлением, которое становится все более очевидным как ключевая тенденция современного, оказавшегося в условиях геополитических вызовов и трансформаций мира, является реализация принципа неограниченного вмешательства политики в профессиональный спорт, прежде всего высоких достижений, что превращает его из фактора, способствующего объединению людей, их взаимопониманию и преодолению культурных, этнических и национальных разногласий, в широко используемый инструмент политического давления на оппонента и жесткого продвижения идеологических проектов. В статье на материале разножанровых публикаций, появившихся в период 2014–2024 гг. в российских и болгарских средствах массовой информации, рассмотрены ключевые аспекты, связанные с использованием спорта и спортивных мероприятий в политико-инструментальных целях, проанализированы некоторые конфликтные ситуации, которых наглядно демонстрируют форсированную политизацию спорта и его зависимость в современном мире от политических структур, которые подчиняют спорт и в частности Олимпийское движение несвойственным им законам. СМИ, как общественно-политические, так и специализированные, являясь инструментом не только общественного диалога, но и управления, создают воспринимаемую самыми широкими аудиторииями «сцену», на которой все чаще разыгрывается идеологические сюжеты, содержащие политически ангажированные смыслы, определения и оценки социальной и спортивной реальности. Сделан вывод о том, что сегодня форсированная политизация спорта становится обыденной реальностью и спорт включается в политику идеологического противостояния. Проведенное исследование позволило выявить транслируемые в общество посредством СМИ оценочные смыслы и политико-идеологические установки.
Характеристики виртуальной языковой личности автора англоязычной сетевой кинорецензии
Authors: Галиуллина Олеся Равильевна 
Published: April 2024

Исследование англоязычной кинорецензии является перспективным в силу необходимости разграничения и систематизации в ней черт институционального дискурса, к которому рецензия традиционно относится, и персонального дискурса, черты которого рецензия приобретает в силу ее перехода на интернет-платформы с их более демократичными лексико-стилистическими нормами. Большинство научных исследований исследований рассматривают рецензию в коммуникативном контексте блог-дискурса и в медиапространстве социальных сетей с их превалирующей функцией по самопрезентации автора. Фигура автора является ключевой и в сетевой кинорецензии, что манифестирует себя в виртуальной языковой личности рецензента. В связи с недостаточной проработанностью вопроса касательно важности роли языковой личности автора кинорецензии с ее набором прагматических интенций обуславливают актуальность данного исследования целью данного исследования является анализ языковой личности автора сетевой кинорецензии. Рассмотрен интеракционный аспект языковой личности кинорецензента, выраженный в вопросно-ответной форме изложения материала и риторических вопросах. Проанализированы эксплицитные средства самопрезентации автора и имплицитные средства достижения перлокутивного эффекта при воздействии на читателя. Сделан вывод о том, что сетевая кинорецензия, с одной стороны, характеризуется аналитичностью и объективностью традиционной рецензии, с другой стороны, схожа с интернет-отзывом, отличающимся высокой степенью экспрессивности и модально-оценочной составляющей.
Социокультурный код языковых личностей драматургов Б. Шоу и А.П. Чехова
Authors: Семченкова Инна Валентиновна 
Published: April 2024

Рассмотрены разноязычные драматургические текстовые форматы. Предложено определение социокультурного текстового кода писателей-драматургов, позволяющее выявить условия функционирования компонентов их идиостилей. Изложен авторский алгоритм исследования социокультурных текстовых кодов. Впервые интерпретирована архитектоника социокультурных текстовых кодов языковых личностей писателей-драматургов в качестве совокупности пяти типов маркеров невербального кода, лингвокультурем и эмотивов. Выявлены тенденции частотности компонентов социокультурных текстовых кодов писателей-драматургов. Представлена сравнительно-сопоставительная таксономическая модель социокультурных текстовых кодов в пьесах «Цезарь и Клеопатра» Б. Шоу и «Чайка» А.П. Чехова, темпорально сопряженных по дате опубликования. Определено, что синхронический спектр функционирования социокультурного текстового кода языковых личностей разноязычных писателей-драматургов характеризуется высокочастотными компонентами, а именно проксемами и кинемами, что обусловлено драматургическим форматом текста.
The Breed of Finfluencer: Catalysts in Shaping Investment Choices
Authors: Dr. S. Subramanian Sherene. A, 
Published: April 2024

Niche social media influencer marketing groups have profoundly transformed the social media landscape, wielding their expertise and passion to engage the target audience within that niche. This trend is no different when it comes to financial influencers (Finfluencer). From stock market gurus to crypto experts, these influential people possess the knowledge, expertise, and experience to guide Social Media Users (SMU) towards successful investments. For this investigation, social media users actively engaged in investment discussions on social media platforms will also be referred to as retail investors. The study aims to analyse independent influence of two key determinants on SMU’s Investment choices: Finfluencer credibility and SMU’s Financial literacy levels. Though the variables are conceptually distinct, yet it is intertwined as the credibility reflects the external perception and financial literacy reflects internal knowledge of SMUs. The credibility variables of Finfluencer to be measured are trustworthiness, goodwill, and expertise. An online survey was distributed to respondents from across Chennai, Tamil Nadu, India. The findings revealed that Finfluencer Credibility has positive influence on the investment decisions. Furthermore, pointing out the significant influence of investors high and low financial literacy levels on investment decisions. The findings of the study will benefit finfluencers and retail investors (SMU) in several ways. In addition, it will have significant implications for Indian fintech companies.
The impact of state and social audit on social development and entrepreneurship in Kazakhstan
Authors: Kogut O. Yu. , Bimendiyeva L. A. , Nurmagambetova Az. Z. 
Published: April 2024

The purpose of the study. In this study, the authors examined the role of state and social audit as the main means of effective coordination of social and labor relations, mainly in modern realities, undoubtedly relevant in the field of auditing activities.Methodology. As a methodological basis, the authors used the research of domestic and foreign scientists in the field of studying government audit and auditing the efficiency of spending public funds, as well as regulations of the Republic of Kazakhstan, international standards of government audit.Originality / value of the research. Consists in the study of theoretical, methodological and real issues of auditing the effectiveness of the execution of government programs and recommendations for increasing the results of auditing the effectiveness of government programs.The results of the study. Transparency of the results of an unsupervised audit can serve as the main means of monitoring the implementation of government social programs, and here the government audit of government concepts, programs, regulations, and so on plays a huge role. Most states are developing a regulatory framework through which government assistance to social entrepreneurship is implemented. The direct influence on the formation of the national economy, which is only growing, is provided by the social processes arising in our society. The formation and preservation by the state of social entrepreneurship is therefore considered valuable. Reducing unemployment and increasing employment levels, the emergence of fundamentally new forms of cooperation with civil society, the modernization of social innovation, and the development of inclusive entrepreneurship are facilitated by the integration of the public sector and entrepreneurship.