bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Review on Hydrogels for Smart Drug Delivery Systems and their Mathematical Modelling
Authors: Kalyani Chinnala , Hitashi Prashant , Gupta Deepshikha , Verma Rohit , Raula Manoj , Varshney Gaurav , Gupta Tejendra K . 
Published: March 2024

Abstract:
Since the last few decades, smart hydrogels have become a vibrant research
area in biomedical science and engineering. Nowadays, smart hydrogels can
be used in drug delivery systems due to their biocompatibility, physicochemical properties,
and high stability. External factors like temperature, pH, ionic concentration,
light, magnetic fields, electrical fields, and chemicals can alter smart hydrogels'
chemical and biological characteristics. Furthermore, there have been sophisticated
advancements in polymer science that combine two or more responsive mechanisms
to create polymers with multiple responsive properties. In this review article, we discussed
the recent advancements in the field of smart hydrogels, their preparation
methods, important properties, and multifunctional applications. The FDA approval
for clinical purposes is also given for specific commercial applications. Various
mathematical models have also been discussed to simulate and optimize the drug release
behavior from hydrogels and to provide valuable insight into the drug release
profile over time. The latest advancement in the field of stimuli-responsive drugloaded
hydrogels and the contributions of the researchers in this field are also highlighted.
Finally, the advantages and disadvantages of smart hydrogels and their future
challenges are also discussed.
An integrated approach in the management of Cardiovascular Diseases
Authors: Pratibha Lokhande  , Babita Sharma  , Nitin Ujjaliya  
Published: March 2024

Cardiovascular diseases (CVDs) are the leading cause of death globally. According to WHO an estimated 17.9 million people died from CVDs in 2019, representing 32% of all global deaths. Of these deaths, 85% were due to heart attack and stroke. India has one of the highest burdens of cardiovascular disease worldwide. The annual number of deaths from CVD in India is projected to rise from 2.26 million (1990) to 4.77 million (2020). The rate of incidence of cardiac disorders is almost doubled in Indian population which is an alarming fact. Cardiovascular Disease is largely the product of interactions of modifiable risk factors like changing lifestyles, bad eating habits and rapidly evolving socio-economic determinants like access to healthcare. There is a need of developing an integrative approach which conceptualizes a unique blend of different systems to bring the balance of body, mind and spirit for perfect health. Ayurveda holds the breakthrough to the key challenges that the India and in turn the world is facing in present era in cardiac care. Various scattered literature can be brought together and a clinical cardiology in Ayurveda can be given to modern society. Present paper is an effort towards Integrative approach for the management of CVDs.
Partial Fistulotomy followed by Kshara application and Ksharasutra Ligation in Fistula-in-ano - Multiple approaches in a Single Case
Authors: Srinivasa NV  , Shilpa PN  
Published: March 2024

Bhagandhara is one of the common ailments pertaining to Guda and it is mentioned under the heading of Ashtomahagada (eight major diseases). According to Acharya Susahruta, ‘Bhagandhara’ starts as deep-seated pidika (boil) surrounding Guda (anus) within two Angulas, producing fever and pain. In contemporary science it is compared to fistula-in-ano. Fistula-in-ano is a track lined by granulation tissue and communicating two epithelial lined surfaces which opens deeply in the anal canal or rectum and superficially on the skin around the anus. In modern medical science various treatment modalities has been explained but they are having its own merits and demerits. Ksharasutra is a medicated thread, indicated in ano-rectal disorders particularly in the management of Bhagandhara. In plane Kshrasutra the required time for cut through and healing of wound is more, so patients are mentally disturbed with this disease. Hence to minimize the required time, multiple interventions along with Ksharasutra is opted. In this case report, a patient of fistula- in-ano having 9cm at posterior aspect of anal canal was treated with multiple approaches which are partial fistulotomy, Kshara application and Ksharasutra ligation for remaining part of tract. Regular dressing was done with Jatyadi Ghrita for the partial fistulotomy wound and old Ksharasutra was changed with a new one by rail-road method on every week for the remaining part of fistulous tract. The unit cutting time (UCT) was measured and noted at every week. This case was cured completely within 7 weeks. Hence study concluded that the long fistula cases can be treated with multiple interventions along with Ksharasutra.
A Novel Ayurvedic treatment - Arthrothermia® for Osteoarthritis
Authors: Shah Prerak , Kagrana Dhruti 
Published: March 2024

Purpose: The purpose of this study was to report promising data revealed by a novel Ayurvedic treatment; Arthothermia® for patients with knee osteoarthritis (OA). Method: We enrolled 30 patients with OA who received Arthothermia® treatment. The Knee injury and Osteoarthritis Outcome Score (KOOS) was used to evaluate the treatment outcome. The five subscales of KOOS: Pain, Other Symptoms, Function in daily living (ADL), Function in Sport and Recreation (Sport/Rec), and knee-related Quality of Life (QOL) were scored separately. The KOOS data was calculated for the 30 patients before and after Arthothermia® treatment. Results: The KOOS before Arthothermia® ranged from 3.37 to 31.3. The KOOS was significantly improved after Arthothermia® and it ranged from 83.67 to 98.53. The difference in KOOS between before and after Arthothermia® treatment was calculated for the 30 patients as a group (unpaired t-test) as well as for each patient individually (paired t-test). The difference in KOOS was highly significant (p<0.0001) for both; unpaired and paired t-test analysis. Conclusion: The present study documented that the “Arthothermia®” – a unique Ayurveda treatment approach (combination of alkaline cautery and indirect micro thermal cautery) brought significant changes in KOOS in the OA patients in very short time duration. The promising data hold a ray of hope for better management of OA and needs wide explorations to bring magnificent outcome for patients suffering with OA.
A tríade universidade, escola e profissão na formação docente: Considerações sobre a verticalização nos Institutos Federais de Educação, Ciência e Tecnologia
Authors: Neuhold Roberta dos Reis , Pozzer Márcio Rogério Olivato 
Published: March 2024

Este artigo contextualiza os cursos de formação inicial de professores na arquitetura institucional de uma política federal brasileira e sinaliza seu potencial de reduzir as distâncias entre universidade, escola e profissão. Sublinhando a urgência de serem constituídas novas institucionalidades que concretizem os processos de formação de professores, António Nóvoa propõe a criação de “casas comuns” capazes de estabelecer ligações orgânicas entre o ambiente acadêmico, o cotidiano escolar e a profissão docente. No Brasil, uma política de abrangência nacional dialoga diretamente com essa proposta. Pouco estudada, começou a ser implementada em 2008, nos Institutos Federais de Educação, Ciência e Tecnologia e tem na verticalização do ensino um dos fundamentos de sua organização político-pedagógica, ofertando cursos de diferentes níveis, incluindo o ensino secundário e as licenciaturas. O quadro docente, por seu turno, com remuneração e plano de carreira equiparados aos professores universitários, leciona, na mesma instituição, tanto na educação básica quanto no ensino superior, atuando como professor pesquisador e formador de professores. É a essa experiência que o presente artigo se reporta. A partir de um estudo qualitativo de enfoque descritivo, recupera os antecedentes da política pública discutindo a fundação dessa nova institucionalidade em um cenário de escassez de professores. Direciona a atenção, então, à inovação institucional propiciada pelo modelo de verticalização, acenando para a sua potencial contribuição na constituição do que Nóvoa nomeia como o triângulo da formação docente, em cujos vértices estariam a escola, a universidade e a profissão. Ao final, problematiza os desafios para a consolidação da proposta.
TES KETERAMPILAN OLAHRAGA JUDO BAGI MAHASISWA
Authors: PIDA JUMHAN 
Published: March 2024

Abstract The research is aimed to construct judo skill test for students, considering there has not been any judo skill test up to the present time. The sample students are the students of the dojo of UNY, taken purposively. The test is constructed in two skill groups, namely Kogo Uchikumi Nage Waza (throwing technique group) and Kogo Uchikumi Katame Waza (gripping technique group). The first group is done by Kogo Uchikumi( variety of technique) namely: (1) one place position, (2) moving backward, (3) moving forward, (4) moving sideward, in 30’ for each variation of technique. Each of the techniques needs 45’, 900 and 1800 of pivoting the body alternatively without going through throwing the second group is done by techniques of gripping the body, arm and neck, alternatively in 30’ the lying position on the mat. Keywords: kogo uchikumi, judo skill
PEMBIAYAAN SMK NEGERI DAN SWASTA DI DIY DALAM ERA OTONOMI
Authors: Wagiran Wagiran 
Published: March 2024

Abstract This research aims to describe vocational high school (VHS) educational budget pattern, its problems, and also the effort solve the problems. This research was conducted at stage as well as private VHSs in Yogyakarta. A sample of 11 state and 26 private VHSs was established. Data were collected by using questionnaire, interview, and document and then analyzed both quantitatively and qualitatively. The results indicate that: (a) Educational budget of state and private VHSs comes from government finance and parents support category, (b) Educational budget of state and private VHSs come more from government than from parents support, whereas that of private VHSs come more from parents than from government. (c) The biggest problem faced by state as well as private VHSs is the delay of payment from the government and the parents. Keywords: Educational Budget Pattern, Vocational High School (SMK)
MODELING DATA FUZZY TIME SERIES WITH USING THE DECOMPOSITION OF SINGULAR AND VALUE THE APPLICATION OF INFLATION INFLUENCE LEVEL IN INDONESIA
Authors: Abadi Agus Maman 
Published: March 2024

The aims of this research are to construct a new method for modeling fuzzy time series data and to apply the method for forecasting Indonesian inflation rate. The procedure of this research is done by the following steps: (1) determine fuzzy relations using table lookup scheme, (2) Apply the singular value decomposition to reduce the unimportant fuzzy relations, (3) apply the method to forecasting Indonesian inflation rate. The result of this research is that it was designed a new method to construct the fuzzy time series model using singular value decomposition method. Then, the method is applied to forecast the Indonesian inflation rate based on fuzzy time series data. Forecasting inflation rate using the proposed method yields a higher accuracy than that using table lookup scheme and neural network methods.
MEASUREMENT OF LONGSOR LAND VULNERABILITY AS A DIFFICULTY PLAN FOR RESOURCES IN RESOURCES
Authors: Nursa'ban Muhammad , Sugiharyanto Sugiharyanto , Khotimah Nurul 
Published: March 2024

The objectives of this research are to: Investigating the level of landslide susceptibility and identifying the distribution of landslide susceptibility locations in Menoreh Mountains area. This is the explorative research. The subject of this research are Menoreh Mountains area in Bagelen, and Bener districts Purworejo regency, in addition to Samigaluh District in Kulonprogo Regency. Land units were chosen as the sample using the purposive area sampling technique. Thirty land units were obtained by overlay maps of slope, geology, and soil types. Data collecting was conducted with observation method and documentation to be analyzed by qualitative deskriptif. Findings shown that (I) the level of landslide susceptibility that is in four categories in Samigaluh and Bener districts are low, medium, high, and very high. While three categories were low, medium, and high clasified in Bagelen district. The distributions of low landslide susceptibility covered about 46.500.527,08 m2 (2 land units in Samigaluh, 3 land units in Bener, and 3 land units in Bagelen). The medium categories covered about 104480073,8 m2 (l land units in Samigaluh, 4 land units in Bener, and 7 land units in Bagelen). High categories covered about 67734399,31 m2 (each of district is 2 land units). The very high categories covered about 12228602,01 m2 (2 land units for both, Samigaluh and Bener District). Key words: landslide, susceptibility, mitigation, hazard, Menoreh
Tepa salira (tenggang rasa) dalam konteks perdamaian dunia
Authors: Istikomah Erna , Hardiyanto Hardiyanto 
Published: March 2024

Penelitian ini bermaksud mengungkap tepa salira dalam konteks perdamaian dunia melalui analisis resepsi. Penelitian ini menggunakan penelitian deskriptif kualitatif. Data dalam penelitian ini yaitu Serat Wedhatama, kebudayaan Jawa, dan referensi terkait tepa salira serta perdamaian dunia. Analisis data menggunakan flow model of analysis. Flow model of analysis merupakan teknik analisis yang mengkaitkan empat komponen: data collection, data display, data reduction, dan conclusion drawing/varivication. Hasil penelitian menunjukkan Serat Wedhatama mengajarkan konsep tepa salira yang terdapat pada: Pangkur bait ke 3-8,10,11 dan Kinanthi bait ke 95-98, melalui petuah yang sebaiknya dilakukan dan dihindari dalam berinteraksi sosial. Konsep tersebut dapat diterapkan dalam berbagai level interaksi sosial, termasuk dalam kehidupan bermasyarakat dunia. Nilai tepa salira melekat kepada setiap individu, maka yang pertama diharapkan sebagai teladan adalah pemimpin negara. Jika setiap pemimpin negara menjadikan humanisasi tepa salira dalam dimensi konsepsi moralitas negaranya maka cepat atau lambat perdamaian dunia akan terwujud. Dengan kata lain, mengedepankan tepa salira dalam interaksi global maupun perpolitikan dunia akan mampu mewujudkan perdamaian dunia.
Estimation of the Population Size of Street- and Venue-Based Female Sex Workers and Sexually Exploited Minors in Rwanda in 2022: 3-Source Capture-Recapture
Authors: Tuyishime Elysee , Remera Eric , Kayitesi Catherine , Malamba Samuel , Sangwayire Beata , Habimana Kabano Ignace , Ruisenor-Escudero Horacio , Oluoch Tom , Unna Chukwu Angela 
Published: March 2024

Background
HIV surveillance among key populations is a priority in all epidemic settings. Female sex workers (FSWs) globally as well as in Rwanda are disproportionately affected by the HIV epidemic; hence, the Rwanda HIV and AIDS National Strategic Plan (2018-2024) has adopted regular surveillance of population size estimation (PSE) of FSWs every 2-3 years.

Objective
We aimed at estimating, for the fourth time, the population size of street- and venue-based FSWs and sexually exploited minors aged ≥15 years in Rwanda.

Methods
In August 2022, the 3-source capture-recapture method was used to estimate the population size of FSWs and sexually exploited minors in Rwanda. The field work took 3 weeks to complete, with each capture occasion lasting for a week. The sample size for each capture was calculated using shinyrecap with inputs drawn from previously conducted estimation exercises. In each capture round, a stratified multistage sampling process was used, with administrative provinces as strata and FSW hotspots as the primary sampling unit. Different unique objects were distributed to FSWs in each capture round; acceptance of the unique object was marked as successful capture. Sampled FSWs for the subsequent capture occasions were asked if they had received the previously distributed unique object in order to determine recaptures. Statistical analysis was performed in R (version 4.0.5), and Bayesian Model Averaging was performed to produce the final PSE with a 95% credibility set (CS).

Results
We sampled 1766, 1848, and 1865 FSWs and sexually exploited minors in each capture round. There were 169 recaptures strictly between captures 1 and 2, 210 recaptures exclusively between captures 2 and 3, and 65 recaptures between captures 1 and 3 only. In all 3 captures, 61 FSWs were captured. The median PSE of street- and venue-based FSWs and sexually exploited minors in Rwanda was 37,647 (95% CS 31,873-43,354), corresponding to 1.1% (95% CI 0.9%-1.3%) of the total adult females in the general population. Relative to the adult females in the general population, the western and northern provinces ranked first and second with a higher concentration of FSWs, respectively. The cities of Kigali and eastern province ranked third and fourth, respectively. The southern province was identified as having a low concentration of FSWs.

Conclusions
We provide, for the first time, both the national and provincial level population size estimate of street- and venue-based FSWs in Rwanda. Compared with the previous 2 rounds of FSW PSEs at the national level, we observed differences in the street- and venue-based FSW population size in Rwanda. Our study might not have considered FSWs who do not want anyone to know they are FSWs due to several reasons, leading to a possible underestimation of the true PSE.
Towards tsunami early-warning with Distributed Acoustic Sensing: Expected seafloor strains induced by tsunamis
Authors: Becerril Carlos , Sladen Anthony , Ampuero Jean-Paul , Vidal-Moreno Pedro J , Gonzalez-Herraez Miguel , Kutschera Fabian , Gabriel Alice-Agnes , Bouchette Frédéric 
Published: March 2024

Tsunami wave observations far from the coast remain challenging due to
the logistics and cost of deploying and operating offshore
instrumentation on a long-term basis with sufficient spatial coverage
and density. Distributed Acoustic Sensing (DAS) on submarine fiber optic
cables now enables real-time seafloor strain observations over distances
exceeding 100 km at a relatively low cost. Here, we evaluate the
potential contribution of DAS to tsunami warning by assessing
theoretically the sensitivity required by a DAS instrument to record
tsunami waves.
Our analysis includes signals due to two effects induced by the
hydrostatic pressure perturbations arising from tsunami waves: the
Poisson’s effect of the submarine cable and the compliance effect of the
seafloor. It also includes the effect of seafloor shear stresses and
temperature transients induced by the horizontal fluid flow associated
with tsunami waves. The analysis is supported by fully coupled 3-D
physics-based simulations of earthquake rupture, seismo-acoustic waves
and tsunami wave propagation. The strains from seismo-acoustic waves and
static deformation near the earthquake source are orders of magnitude
larger than the tsunami strain signal. We illustrate a data processing
procedure to discern the tsunami signal. With enhanced low-frequency
sensitivity on DAS interrogators (strain sensitivity ≈
2×10 at mHz frequencies), we find that, on seafloor
cables located above or near the earthquake source area, tsunamis are
expected to be observable with a sufficient signal-to-noise ratio within
a few minutes of the earthquake onset. These encouraging results pave
the way towards faster tsunami warning enabled by seafloor DAS.
Simple scores to predict 1-year mortality in atrial fibrillation
Authors: Cemin Roberto , Maggioni Aldo Pietro , Gonzini Lucio , Di Pasquale Giuseppe , Boriani Giuseppe , Di Lenarda Andrea , Nardi Federico , Gulizia Michele Massimo ,   BLITZ-AF Investigators
Published: March 2024

Background
Traditional scores as CHADS2 and CHA2DS2-Vasc are suitable for predicting stroke and systemic embolism in patients with atrial fibrillation (AF) and have shown to be also associated with mortality. Other more complex scores have been recommended for survival prediction. The purpose of our analysis was to test the performance of different clinical scores in predicting 1-year mortality in AF patients.

Material and methods
CHADS2 and CHA2DS2-Vasc scores were calculated for AF patients of the BLITZ-AF register and compared to R2-CHADS2, R2-CHA2DS2-Vasc and CHA2DS2VASc-RAF scores in predicting 1-year survival. Scores including renal function were calculated both with glomerular filtration rate (GFR) and creatinine clearance.

Results
One-year vital status (1960 alive and 199 dead) was available in 2159 patients. Receiver-operating characteristic curves displayed an association of each score to all-cause mortality, with R2(ClCrea)-CHADS2 being the best [area under the curve (AUC) 0.734]. Differences among the AUCs of the eight scores were not so evident, and a significant difference was found only between R2(ClCrea)-CHADS2 and CHADS2, CHA2DS2VASc, (ClCrea)-CHA2DS2-VASC-RAF.
All the scores showed a similar performance for cardiovascular (CV) mortality, with CHA2DS2VASc-RAF being the best (AUC 0.757), with a significant difference with respect to CHADS2, CHA2DS2VASc, and (ClCrea)CHA2DS2Vasc-RAF.

Conclusions
More complex scores, even if with better statistical performance, do not show a clinically relevant higher capability to discriminate alive or dead patients at 12 months. The classical and well known CHA2DS2VASc score, which is routinely used all around the world, has a high sensitivity in predicting all-cause mortality (AUC 0.695; Sensit. 80.4%) and CV mortality (AUC 0.691; Sensit. 80.0%).

Graphical abstract

http://links.lww.com/JCM/A632
The Role of Pyramidal Organizational Structure in Organizational Efficiency and Effectiveness
Authors: Hajdari Rozafa , Jupa Njomza 
Published: March 2024

Abstract
The purpose of this article is the theoretical treatment of organizational structuring aspect, with special emphasis on the role of pyramidal organizational structure in organizational efficiency and effectiveness. More broadly, it talks about the importance of the organizational structure for the division of tasks, roles, responsibilities, authority and so on, as well as the importance of the optimal breadth of management in the success of organizations, respectively in the correct and clear understanding of roles of each member within the organization. Likewise, it is intended that through the study carried out in 50 enterprises in Kosovo, the importance of applying an adequate organizational structure that ensures their success will be presented. The study made it clear at what level the pyramidal organizational structure is applied by these enterprises and how much efficiency and effectiveness this structure has provided to them.
Team Roles in Family Businesses and Quality of Family Business – Case Study
Authors: Linhart Ondřej , Rydvalová Petra 
Published: March 2024

Abstract
Team roles, personal character, and temperament play a key role in team management. The unique approach brought by Dr. M. Belbin´s unique approach, known as the Belbin Team Roles, is widely used in education, research, and professional consultancy. However, there is a significant gap in research on team roles in family businesses, which hinders the understanding of a specific form of human economic activity: family business.
The aim of this article is to show the methodology used in the research of team roles in family businesses, with a focus on family business quality in one specific Czech company. The company was evaluated using Belbin Team Roles 360-degrees analysis and a Family Business Quality self-evaluating questionnaire. This case study provides a foundation for future research in this area.