bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chiral nitrone reagents for cycloaddition reactions
Authors: Jones Raymond C. F. , Martin Jason N. , Smith Paul 
Published: March 2009

AbstractThe preparation and cycloaddition reactions of new imidazoline nitrones are described. The imidazo[1,2‐b]isoxazole alkene cycloadducts are formed via an exo approach. An example has been tranformed into a pyrrolo[1,2‐a]imidazole as a prelude to a new pyrrolidine synthesis.
Reactions of 1‐(3‐aryl‐3‐oxopropenyl)azulenes and 1‐cinnamoylazulenes with malononitrile: Synthesis of 1‐(2‐aryl‐4‐pyridyl)azulenes and 1‐(4‐aryl‐2‐pyridyl)azulenes
Authors: Wang Dao‐Lin , Imafuku Kimiaki 
Published: March 2009

AbstractThe reactions of 1‐formyl‐3‐methoxycarbonylazulene (1) with acetophenones 3a‐e gave 1‐(3‐aryl‐3‐oxopropenyl)‐3‐methoxycarbonylazulenes 4a‐e which reacted with malononitrile in the presence of sodium methoxide to afford 1‐(2‐aryl‐4‐pyridyl)‐3‐methoxycarbonylazulenes 9a‐d, except for 4′‐nitro‐substituted compounds. Heating of the compounds 9a‐d in 100% phosphoric acid yielded 1‐(2‐aryl‐4‐pyridyl)azulenes 10a‐d. In a similar manner, 1‐(4‐aryl‐2‐pyridyl)azulenes 12a‐1 and 1‐[4‐(2‐furyl)‐ and 4‐(2‐thienyl)‐2‐pyridyl)]azulenes 14a,b were obtained.
Chlorination of 3,4,5‐trichloropyridazin‐6‐one and synthesis of 3,4,5‐trichloro‐1‐(4,5,6‐trichloropyridazin‐3‐yl)pyridazin‐6‐one
Authors: Kang Young‐Jin , Lee Woo Song , Kim Ho‐Kyun , Yoon Yong‐Jin , Shiro Motoo 
Published: March 2009

AbstractThis paper presents the chlorination of 3,4,5‐trichloropyridazin‐6‐one and the synthesis of 3,4,5‐trichloro‐1‐(4,5,6‐trichloropyridazin‐3‐yl)pyridazin‐6‐one.
Synthesis of substituted tetrahydroisoquinolines and benzo[d]azepines from phthalan or isochroman and N‐silylaldimines
Authors: Foubelo F. , Gómez C. , Gutiérrez A. , Yus M. 
Published: March 2009

AbstractThe 4,4′‐di‐tert‐butylbiphenyl‐catalyzed lithiation of phthalan (1a) and isochroman (1b) in THF at 0°C affords the corresponding functionalized benzyllithiums 2, which by reaction with N‐silylaldimines yield, after acid‐base work‐up, the expected amino alcohols 3. Successive treatment of these amino alcohols with thionyl chloride and sodium hydroxide yields the corresponding substituted benzofused six‐ and seven‐membered nitrogen‐containing heterocycles 4.
Synthesis and properties of new types of sulfoxide‐ or sulfone‐bridged lewis acids
Authors: Ohba Yoshihiro , Ito Kazuaki , Nagasawa Tomomi , Sakurai Shinya 
Published: March 2009

AbstractA series of new types of sulfur‐bridged Lewis acids were synthesized. The ligands that contained the sulfoxide or sulfone as the joint moieties of two phenols were found to quantitatively give Lewis acids. These obtained Lewis acids also have good discrimination properties of some epoxides. The reaction prop erties of the Lewis acids were studied using the rearrangement of the epoxides to carbonyl compounds.
Synthesis of novel 3‐ and 5‐substituted indole‐2‐carboxamides
Authors: Bratton Larry D. , Roth Bruce D. , Trivedi Bharat K. , Unangst Paul C. 
Published: March 2009

AbstractThe preparation of several novel 3,5‐substituted‐indole‐2‐carboxamides is described. A 5‐nitro‐indole‐2‐carboxylate was elaborated to the 3‐benzhydryl ester, N‐substituted ester, and carboxylic acid intermedi ates, followed by conversion to the amide and then reduction of the 5‐nitro group to the amine. Indole‐2‐carboxamides with 3‐benzyl and 3‐phenyl substituents were prepared in four steps from either a 3‐bromo indole ester using the Suzuki reaction or from a 3‐keto substituted indole ester. N‐Alkylation of ethyl indole‐2‐carboxylate, followed by amidation and catalytic addition of 9‐hydroxyxanthene gave a 3‐xanthyl‐indole‐2‐carboxamide analog and a spiropyrrolo indole as a side product.
Further studies on polycyclic arene sulfides. Preparation and mutagenic activity of 9, 10, 10a, 11a‐tetrahydrotriphenyleno[1,2‐b]‐thiirene, 1a,2,3,10b‐tetrahydro‐5H‐thiereno[3,4]benzo[1,2‐b]fluorene and 1a,2,3,11b‐tetrahydroacenaphtho[1′,2′:6,7]naphth[1,2‐b]thiirene
Authors: Blum Jochanan , Kogan Vladimir , Glatt Hansruedi 
Published: March 2009

AbstractThe title compounds 6, 8 and 10, which are dihydroarene sulfides of the environmental pollutants triphenylene, benzo[b]fluorene and benzo[k]fluoranthene, have been synthesized from the corresponding epoxides and N,N‐dimethylthioformamide. The mutagenicity of the episulfides has been investigated using Salmonella typhimurium strains TA98 and TA100. While compounds 6 and 10 were mutagenic, the tetrahydrobenzo[b]fluorene episulfide 8 was inactive.
Synthesis of 9‐[2‐(2‐hydroxymethyl‐2‐methyl‐, ‐(2‐acetoxymethyl‐2‐methyl‐, ‐(2,2‐di(hydroxymethyl)‐, and ‐(2,2‐Di(acetoxymethyl)‐1,3‐dioxan‐5‐yl)ethyl] derivatives of guanine and 2‐aminopurine
Authors: Kim Dae‐Kee , Lee Namkyu , Kim Young‐Woo 
Published: March 2009

AbstractSynthesis of 9‐[2‐(2‐hydroxymethyl‐2‐methyl‐, ‐(2‐acetoxymethyl‐2‐methyl‐, ‐(2,2‐di(hydroxymethyl)‐, and ‐(2,2‐di(acetoxymethyl)‐1,3‐dioxan‐5‐yl)ethyl] derivatives of guanine and 2‐aminopurine,2–9, has been accomplished in seven to eight step sequences from readily available 1‐(tert‐butyldiphenylsilyloxy)‐acetone, 1,3‐di(tert‐butyldiphenylsilyloxy)acetone, and the diol10. Formation of cyclic ketals11and12was carried out successfully under an acidic condition using a catalytic amount of methanesulfonic acid along with excess anhydrous copper(II) sulfate in toluene. Subsequent reactions of desilylation, acetylation, hydrogenolysis, and bromination afforded the key intermediates19and20, which were coupled with 2‐amino‐6‐chloropurine to produce the purine compounds21and22in good yields. Guanine derivatives2–5were obtained from21and22by hydrolysis and acetylation, while the dechlorination and hydrolysis of21and22yielded the 2‐aminopurine compounds6–9.
Facile syntheses of homothia‐ and homoazacalixarenes
Authors: Ito Kazuaki , Nagai Takanori , Ohba Yoshihiro , Sone Tyo 
Published: March 2009

AbstractDecahomotetrathiacalix[6]arenes were conveniently prepared from the 2:2 cyclization reactions of bis(chloromethyl)phenol‐formaldehyde trimers with 1,2‐ethanedithiol in high yields. In contrast, the simi lar reactions of the trimers with 1,3‐propanedithiol instead of 1,2‐ethanedithiol gave 1:1 macrocycles, hexahomodithiacalix[3]arenes, in good yields. Homoazacalixarenes were also prepared from the analogous reactions using piperazines. These macrocycles adopt a cone‐like form as a preferable conformation in solution.
Total syntheses of (±)‐cis‐ and trans‐11‐methoxydeethyleburnamonine
Authors: Rönkkö Kalle , Berner Mathias , Jokela Reija , Tolvanen Arto 
Published: March 2009

AbstractThe total syntheses of 11‐methoxydeethyleburnamonines (4) and (13) were carried out with use of 6‐methoxytryptophyl bromide (5) as starting material. Compound 5 was converted in three steps to trans‐ester 8. Acid‐catalysed epimerization of 8, lithium aluminum hydride reduction of the ester group, tosylation and substitution with cyanide gave the cis‐nitrile 12. Acid‐induced cyclization of 12 yielded mainly (±)‐trans‐11‐methoxydeethyleburnamonine (13), whereas base‐induced cyclization gave (±)‐cis‐11‐methoxydeethyleburnamonine (4).
New synthetic approaches to bridgehead nitrogen heterocycles. Derived from 3‐amino‐2,3‐dihydro‐5,6‐dimethyl‐2‐thioxothieno[2,3‐d]pyrimidin‐4(1H)‐one and its salts
Authors: Santagati Andrea , Modica Maria , Santagati Maria 
Published: March 2009

AbstractBridgehead nitrogen heterocycles 3a, b and 6a, b containing the thieno‐pyrimidine system have been prepared from the versatile intermediates 3‐amino‐2,3‐dihydro‐5,6‐dimethyl‐2‐thioxo‐thieno[2,3‐d]pyrimidin‐4‐(1H)‐one 1 and its hydrazinium or potassium salts 4; their structural elucidation is also reported.
Synthesis of acyclic nucleoside phosphonates as antiviral compounds
Authors: Wormstädt Frank , Gütschow Michael , Eger Kurt , Brinckmann Ute 
Published: March 2009

AbstractReaction of 6‐chloropyrimidines with diethyl [(2‐aminoethoxy)methyl]phosphonate allows for a ready access to acyclic nucleoside phosphonates. A series of 5‐substituted pyrimidines bearing a phosphonate side chain at position 6 were synthesized and tested against herpes simplex viruses (HSV‐1 and HSV‐2) and human immunodeficiency virus (HIV‐1). Some compounds showed weak antiviral activity against HSV‐1.
One‐Pot synthesis of isothiachromene, isochromene, isoquinoline and tetrahydronaphthalene derivatives
Authors: El‐Sayed A. M. , Abdel‐Ghany H. 
Published: March 2009

AbstractA new series of tetrahydronaphthalene, isothiachromene, isochromene and isoquinoline derivatives were synthesized by reacting cyclohexylidenemalononitrile with active nitriles, active halo compounds, carbon disulfide, aldehydes, isothiocyanates and isocyanates, respectively.
A convenient synthesis of pyrazolo[3,4‐d]pyrimidine‐4,6‐dione and pyrazolo[4,3‐d]pyrimidine‐5,7‐dione derivatives
Authors: El Haddad M. , Soukri M. , Lazar S. , Bennamara A. , Guillaumet G. , Akssira M. 
Published: March 2009

AbstractPyrazolo‐[3,4‐d]pyrimidine‐4,6‐diones 5 and pyrazolo[4,3‐d]pyrimidine‐5,7‐diones 7 were synthesized by Curtius rearrangement of pyrazolic mono‐esters 2 and 3 followed by hetero‐cyclization via the ureas derivatives 4 and 6 under alkaline conditions.
Synthesiss of novel 3‐(2‐thienyl)‐1,2‐diazepino[3,4‐b]quinoxalines with algicidal activity
Authors: Kim Ho Sik , Jeong Geuk , Lee Hyoung Choul , Kim Jin Hee , Park Yong Tae , Okamoto Yoshihisa , Kajiwara Shinnosuke , Kurasawa Yoshihisa 
Published: March 2009

AbstractThe reaction of the quinoxaline N‐oxide 1 with thiophene‐2‐carbaldehyde gave 6‐chloro‐2‐[1‐methyl‐2‐(2‐thienylmethylene)hydrazino]quinoxaline 4‐oxide 5, whose reaction with 2‐chloroacrylonitrile afforded 8‐chloro‐2,3‐dihydro‐4‐hydroxy‐1‐methyl‐3‐(2‐thienyl)‐1H‐1,2‐diazepino[3,4‐b]quinoxaline‐5‐carbonitrile 6. The reaction of compound 6 with various alcohols in the presence of a base effected alcoholysis to provide the 5‐alkoxy‐8‐chloro‐2,3,4,6‐tetrahydro‐1‐methyl‐4‐oxo‐3‐(2‐thienyl)‐1H‐1,2‐diazepino[3,4‐b]‐quinoxalines 7a‐d. The reaction of compounds 7a and 7b with diethyl azodicarboxylate effected dehydrogenation to give the 5‐alkoxy‐8‐chloro‐4,6‐dihydro‐1‐methyl‐4‐oxo‐3‐(2‐thienyl)‐1H‐1,2‐diazepino[3,4‐b]‐quinoxalines 8a and 8b, respectively. Compounds 8a and 8b were found to show good algicidal activities against Selenastrum capricornutum and Nitzchia closterium.
Synthesis of new bis(2,4‐dimethyl‐5‐amino‐benzo[b][1,8]‐naphthyridines) and bis(benzo[b][1,8]naphthyridones) linked with methylene linear chain
Authors: Afloroaei Cerasella , Dulamita Nicu , Vlassa Mircea , Barbe Jacques , Brouant Pierre 
Published: March 2009

AbstractThe preparation of novel alkyl monobridged 2,4‐dimethyl‐5‐amino‐benzo[b][1,8]naphthyiridine and benzo[b][1,8]naphthyridone derivatives by phase transfer catalysis is reported.
Syntheses of 2,3‐dicyano‐5a,8a‐dihydro‐5a‐hydroxycyclopentano[1′,2′:4,5]pyrrolo[2,3‐b]pyrazines and 2,3‐dicyanocyclohexano[1′,2′:4,5]pyrrolo‐[2,3‐b]pyrazines
Authors: Shirai Kazuko , Fukunishi Koushi , Hou Dongfeng , Matsuoka Masaru 
Published: March 2009

AbstractPreviously synthesized 2‐(3′‐chloro‐5′,6′‐dicyanopyrazin‐2′‐yl)cyclopentan‐1‐one 1, obtained from the reaction of 2,3‐dichloro‐5,6‐dicyanopyrazine with 1‐pyrrolidino‐1‐cyclopentene, was further reacted with primary alkylamines to give mixtures of diastereomer of 5‐alkyl‐2,3‐dicyano‐5a,8a‐dihy‐dro‐5a‐hydroxycyclopentano[1′,2′:4,5]pyrrolo[2,3‐b]pyrazines 3a‐h in high yield. The reaction of 2‐alkylamino‐3‐chloro‐5,6‐dicyanopyrazine with 1‐pyrrolidino‐1‐cyclohexene gave 5‐alkyl‐2,3‐dicyanocyclopentano[1′,2′:4,5]pyrrolo[2,3‐b]pyrazines 5a‐b together with 5‐alkylamino‐2,3‐dicyano‐6‐pyrrolidinopyrazines 6a‐b. The products prepared are all of interest as potential pesticides and new fluorescent chromophores.
Synthesis of new C2 symmetrical dibenzospirodiamide and dibenzospirodiamine as potential chiral auxiliaries and building blocks of ionophores
Authors: Choi Heung‐Jin , Park Yang Jin , Kim Moon Goo , Park Yeon Sil 
Published: March 2009

Abstract2,8‐Diazadibenzo[c,i]spiro[5,5]undecan‐1,7‐dione 3 are synthesized via reaction of malonic ester with 2‐nitrobenzyl bromide, followed by reduction‐cyclization in 86% overall yield. 2,8‐Diazadibenzo[c,i]‐spiro[5,5]undecane 4 was obtained by reduction of 3 with LiAIH4 in 90% yield. N‐Alkylation of 3 with various alkylating reagents is studied.
Convenient one‐pot syntheses of pyrazoles from imines, a vilsmeier type reagent and hydrazine
Authors: Katritzky Alan R. , Denisenko Anna , Denisenko Sergey N. , Arend Michael 
Published: March 2009

AbstractA simple one‐pot procedure for the regioselective synthesis of pyrazoles from readily available starting materials is described. Vilsmeier type reagent 1 reacts with imines 10 (via the corresponding tautomeric secondary enamines) in tetrahydrofuran to give enaminoimine hydrochlorides 11. Nonsymmetrical imines generally react preferentially with 1 at the sterically less hindered α‐position. The enaminoimine hydrochlorides 11 are transformed in situ to the corresponding pyrazoles 12 in moderate to high yields by the addition of hydrazine.
Selenium heterocycles XLIV. Syntheses of 8,9‐dihydro‐1,2,3‐thiadiazolo[4,5‐a]‐4,7‐dihydroxynaphthalene and 1,2,3‐selenadiazolo[4,5‐a]‐4,7‐dimethoxynaphthalene
Authors: Shafiee A. , Jalilian A. R. , Rezaei M. 
Published: March 2009

AbstractThe reaction of thionyl chloride with the semicarbazone 2 gave 4,5‐dihydro‐6,9‐dihydroxynaphtho‐[1,2‐d][1,2,3]thiadiazole (3) instead of 4,5‐dihydro‐6,9‐dimethyoxynaphtho[1,2‐d][1,2,3]thiadiazole (4). Selenium dioxide oxidation of compound 2 gave 4,5‐dihydro‐6,9‐dimethyoxynaphtho[1,2‐d][1,2,3]selenadiazole (5). Oxidation of compound 5 with 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone afforded 6,9‐dimethyoxynaphtho[1,2‐d][1,2,3]selenadiazole (6).
Carbocyclic 5′‐norcytidine (5′‐norcarbodine)
Authors: Hegde Vishnumurthy R. , Seley Katherine L. , Schneller Stewart W. 
Published: March 2009

AbstractA preparation of (1′R,2′S,3′R,4′S)‐1‐(2′,3′,4′‐trihydroxycyclopent‐1′‐yl)‐lH‐cytosine (5′‐norcarbodine, 3) has formally been achieved in 2 steps from (+)‐(1R,4S)‐4‐hydroxy‐2‐cyclopenten‐1‐yl acetate (4) and cytosine. The L‐like enantiomer of 3 (that is, 6) is also reported using the enantiomer of 4 (that is, 7). In evalu ating 3 and 6 for antiviral potential against a number of viruses, compound 3 was found to have activity towards Epstein‐Barr virus (EBV).
Novel and efficient one‐pot synthesis of azuleno[1,2‐b]‐benzothiophenic enones from the corresponding 2‐cycloheptatrientyl‐3‐(2‐furyl)benzothiophenes
Authors: Houda Yuuko , Sasabe Misako , Bo Xu , Takagi Hideki , Yamamura Kimiaki 
Published: March 2009

Abstract2‐Cycloheptatrienyl‐3‐(2‐furyl)benzothiophenes, which are prepared by Stille coupling reaction of 2‐cyclo‐heptatrienyl‐3‐bromobenzothiophene with the 5‐substituted 2‐trimethylstannylfurans, react with triphenylmethyl tetrafluoroborate to give the corresponding azuleno[1,2‐b]benzothiophenic enones in excellent yields.
Synthesis and stereochemical studies of 2‐substituted thiazolidine‐4‐carboxamide derivatives
Authors: Refouvelet Bernard , Pellegrini Nadia , Robert Jean‐François , Crini Gregorio , Blacque Olivier , Kubicki Marek M. 
Published: March 2009

AbstractA series of new 2‐substituted thiazolidine‐4‐carboxamide derivatives which have potentially useful immunological properties, have been synthesized in a stereoselective manner by coupling 2‐subsituted thiazolidine‐4‐carboxylic acids with amines or amino esters. The structure of these compounds was established by combination of NMR methods and by X‐ray analysis.
Photochromic fulgides: Transformation of the non‐photochromic (Z)‐isomer of a fulgide into a highly photochromic (E)‐isomer via structural modification involving enhanced conjugation
Authors: Sun Zhiyuan , Hosmane Ramachandra S. , Tadros Maher 
Published: March 2009

AbstractThe non‐photochromic fulgide (1‐Z) has been successfully converted into the highly photochromic (3‐Z) analogue. A dicyanomethylene group was introduced at the 5‐position of 1‐Z in order to enhance the latter's conjugation properties that would facilitate the photochemical Z→E isomerization process. The irradiation of the product 3‐Z with a UV light at λmax 350 nm formed a bluish green solution which absorbed at λmax 620 nm, corresponding to the ring‐closed product 4. The latter was also formed from the reference dicyanomethylene product 3‐E synthesized from 1‐E. The irradiation of 4 at λmax 532 nm produced the reversion to the original pale yellow color of 3‐E.
2,4,6‐trichloropyrimidine. Reaction with anilines
Authors: Schomaker Jennifer M. , Delia Thomas J. 
Published: March 2009

AbstractThe reaction of 2,4,6‐trichloropyrimidine 1 with a variety of 4‐substituted anilines 2 has been investigated. Monosubstitution occurs readily for all anilines except those containing strongly electron‐withdrawing groups. The yields of the isomeric products 3 and 4 parallel the Hammet constants of the ring substituents. The main product when ethanol was used as the solvent was the 4‐substituted‐2,6‐dichloropyrimidine 3. Spectral and X‐ray data confirmed this assignment. However, a solvent dependence on the 3:4 ratio was demonstrated. In some cases, excess aniline under forcing conditions led to 2,4‐disubstituted products.
Syntheses and properties of tetraaza‐, diaza‐, tetraoxa‐, and dioxa‐metacyclophanes
Authors: Ito Kazuaki , Ohba Yoshihiro , Shinagawa Eita , Nakayama Satoshi , Takahashi Shigemi , Honda Katsuhiko , Nagafuji Hidekazu , Suzuki Akane , Sone Tyo 
Published: March 2009

AbstractMetacyclophanes were prepared by cyclization reactions between bis(chloromethyl) compounds and piperazine, primary amines, or ethylene glycol. The 1H nmr relaxation time (T1) measurements indicated that the macrocycles feature the up and down motion of the aromatic units around the XCH2Ar (X = N, O) methylene moieties as the axes. Metacyclophanes incorporating piperazine units showed high complexation ability for alkaline metal cations.
Studies on isocyanides and related compounds. Synthesis of furan derivatives and their transformation into indole derivatives
Authors: Marcaccini Stefano , Pepino Roberto , Marcos Carlos F. , Polo Cecilia , Torroba Tomás 
Published: March 2009

AbstractThe intramolecular Knoevenagel condensation ofN‐cyclohexyl 3‐aryl‐2‐(2‐nitrophenyl)acetoxy‐3‐oxopropionamides 4 obtained from 2‐nitrophenylacetic acid (1), arylglyoxals 2 and cyclohexyl isocyanide (3) affordedN‐cyclohexyl 3‐aryl‐2,5‐dihydro‐2‐(2‐nitrophenyl)‐5‐oxofuran‐2‐carboxamides 6 which underwent reductive cleavage toN‐cyclohexyl (Z)‐3‐aryl‐2‐hydroxy‐3‐(2,3‐dihydro‐2‐oxoindol‐3‐ylidene)propionamides 8 probablyviathe labile intermediates 7.
Preparation of thiochromans via thermal cyclization
Authors: Jensen Anton W. , Manczuk Joan , Nelson David , Caswell Onalee , Fleming Steven A. 
Published: March 2009

AbstractFormation of the thiochroman ring system is achieved by a two step synthesis that involves heating 3‐thiophenyl‐1‐propanols or 4‐thiophenyl‐2‐butanols in toluene with catalytic amounts of p‐toluenesulfonic acid. The propanols are made by the addition of sulfur stabilized carbanions to styrene oxide, ethylene oxide, propylene oxide, and isobutylene oxide. The carbanions are generated by treatment of either benzyl phenyl sulfide or thioanisole with butyllithium. The effect of substitution at the 1 and 3 positions of the propanols on the reaction yields is discussed. The mechanism of the reaction apparently involves intramolecular electrophilic aromatic substitution rather than a Claisen or thio‐Claisen rearrangement.
Oxidant promoted 1,3‐dipolar cycloaddition of benzimidazolium ylides to alkenes for preparation of 4H‐pyrrolo[1,2‐a]benzimidazole
Authors: Wang Bingxiang , Hu Jiaxin , Zhang Xuechun , Hu Yuefei , Hu Hongwen 
Published: March 2009

AbstractAn oxidant promoted 1,3‐dipolar cycloaddition of benzimidazolium ylides to alkenes was developed for the preparation of 4H‐pyrrolo[1,2‐a]benzimidazole derivatives in moderate yields under mild conditions. In the presence of a suitable oxidant, the most commercially available “normal” alkenes, instead of alkynes or “abnormal” alkenes, could be used as dipolarophiles successfully. Moreover, CrO3/Et3N has been proved to be a more effective dehydrogenating reagent than MnO2 or tetrakispyridine cobalt (II) dichromate (TPCD) in this procedure.
Experimental and theoretical structural study of 2‐pyridyl‐ and 4‐hydroxyphenyl‐1,4‐dihydropyridine derivatives
Authors: De Armas Héctor Novoa , Blaton Norbert , Peeters Oswald M. , De Ranter Camiel , Suárez Margarita , Rolando Emilio , Verdecia Yamila , Ochoa Estael , Martín Nazario , Quinteiro Margarita , Seoane Carlos , Soto José L. 
Published: March 2009

AbstractA series of substituted 1,4‐dihydropyridines (1,4‐DHPs) has been synthesised following the well‐known Hantzsch's procedure for symmetrical 1,4‐DHP. The structures of these compounds have been thoroughly studied by X‐ray crystallographic analysis and semiempirical (AMI) calculations. A good agreement is found between the theoretical and experimental results. In all cases, the most stable conformation fulfils all the requirements needed for exhibiting an antagonist calcium effect.
Reaction of chloropyridazines with N,N‐dimethylformamide
Authors: Lee Woo Song , Yoon Yong‐Jin , Kim Sung‐Kyu 
Published: March 2009

AbstractChloropyridazine derivatives 1, 3, 5, 7 and 10a‐c were reacted with N,N‐dimethylformamide under reflux condition to give the corresponding N,N‐dimethylaminopyridazines 2, 4, 6, 8, 9 and 11a‐c regio‐selectively.
Synthesis of 3‐(2‐benzyloxy‐6‐hydroxyphenyl)‐1‐methylpyrazoles by the reaction of chromones with methylhydrazine
Authors: Pinto Diana C. G. A. , Silva Artur M. S. , Cavaleiro José A. S. 
Published: March 2009

AbstractThe 3‐(2‐benzyloxy‐6‐hydroxyphenyl)‐5‐(methyl, phenyl or styryl)pyrazoles were prepared from the reaction of 2‐(methyl, phenyl or styryl)chromones with methylhydrazine. The structure of these compounds has been determined by several nmr techniques, and the reaction mechanism is discussed.
Reaction of pyrroles with naphthoquinones. Synthesis of new pyrrolylnaphthoquinone dyes
Authors: Lion Claude , Baudry Richard , Hedayatullah Mir , Da Conceição Louis , Hocquaux Michel , Genard Sylvie , Maignan Jean 
Published: March 2009

AbstractThe reaction of 1,4‐naphthoquinone (1) with N‐alkylpyrroles (2) gives a mixture of 2‐(pyrrol‐2‐yl)‐1,4‐naphthoquinones (3) and 2,5‐bis(1,4‐naphthoquinon‐2‐yl)pyrroles (4). The yields and the ratios of these two products depend greatly on the experimental conditions. The reaction has been extended to 5‐hydroxy‐1,4‐naphthoquinone (juglone, 5) and 1,2‐naphthoquinone (6). New pyrrolylnaphthoquinones are obtained.
Dipolar 1,3‐cycloaddition of arylnitriloxides on 1,2‐dihydroisoquinolines in a two‐phase medium
Authors: Kitane Said , Taimi Amina , Bahloul Abdelmejid , Sebban Abdelfatah , Berrada Mohamed , Joly Jean‐Pierre 
Published: March 2009

AbstractThe 1,3‐dipolar cycloaddition of arylnitriloxides on 1,2‐dihydroisoquinoline derivatives led to new 3‐aryl, 3a‐8,9,9a‐tetrahydro[5,4‐c]‐isoxazoloisoquinoline adducts. The regioselectivity of the cycloaddition reactions is discussed on the basis of 1H and 13C NMR data.
Total synthesis of homalicine and its related dihydro aglycon
Authors: Zamani Khosrow , Rama Nasim Hassan , Iqbal Rashid 
Published: March 2009

AbstractThe condensation of homophthalic acid (1) with 3‐methoxybenzoyl chloride, followed by demethylation gave 3‐(3‐hydroxyphenyl)isocoumarin (3b). Reaction of (3b) with α‐tetraacetobromo glucose yielded tetraacetylhomalicine (3d), which was deacetylated to homalicine (3e).
Syntheses of 2,4‐diaryl‐2,3‐dihydro‐1,5‐benzothiazepines
Authors: Katritzky Alan R. , Rogovoy Boris V. , Chassaing Christophe , Vvedensky Vladimir , Forood Behrouz , Flatt Brenton , Nakai Hisao 
Published: March 2009

AbstractThe condensation of α,β‐unsaturated ketones with substituted o‐aminothiophenols, obtained by reductive cleavage of the corresponding disulfides in the presence of triphenylphosphine, is an effective method for the synthesis of 2,4‐diaryl‐2,3‐dihydro‐1,5‐benzothiazepines under neutral conditions.