bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contexts of Accountability Under Systemic Reform: Implications for Principal Influence on Instruction and Supervision
Authors: Marks Helen M. , Nance Jason P. 
Published: February 2007

Purpose: The study investigates how various accountability contexts—including states, local boards, districts, school site councils, parent associations, and teachers—affect the ability of principals to influence instructional and supervisory decisions in their schools. Data: Data for the analysis come from 1999-2000 Schools and Staffing Survey responses of 8,524 elementary, middle, and high school principals in low-, moderate-, and high-control states. Principals responded to queries regarding their personal influence and the influence of various other policy actors on decisions in the instructional and supervisory domains in the principals’ schools. Analysis: To examine variation in principal influence within and between states, the study uses hierarchical linear modeling as its primary analytic technique. Findings: Results indicate that the various accountability contexts differentially affect principals’ influence, which also vary by domain, extent of state control, and region. Implications for Practice: Principals’ influence in both the supervisory and instructional domains is strongly related to that of teachers’ active participation in decision making, suggesting the benefits of mutuality in school leadership. Implications for Research: How do state accountability systems differ in relation to improving student achievement? How has an accountability-influenced learning process led to the reculturing of a school district and its schools?
Teacher Teams and Distributed Leadership: A Study of Group Discourse and Collaboration
Authors: Scribner Jay Paredes , Sawyer R. Keith , Watson Sheldon T. , Myers Vicki L. 
Published: February 2007

Purpose: This article explores distributed leadership as it relates to two teacher teams in one public secondary school. Both situational and social aspects of distributed leadership are foci of investigation. Methods: The qualitative study used constant comparative analysis and discourse analysis to explore leadership as a distributed phenomenon. Data from field notes and video recordings of two teacher teams during one semester were used. Findings: Three constructs emerged that informed our understanding of collaborative interaction within each professional learning team: purpose, autonomy, and patterns of discourse. Purpose and autonomy, manifest as organizational conditions, largely shape patterns of discourse that characterize the interaction of the team members. We argue that the nature of purpose and autonomy within a teacher team can influence the social distribution of leadership. Conclusions: The nature of teams in shared governance structures—the fact that teams can organize to either find or solve problems—has important implications for the creative and leadership capacity of individual teams. Thus, structures and social dynamics of distributed leadership must be attended to and not taken for granted. Implications include (a) conceptualizing leadership in terms of interaction, (b) needing to help teachers become aware of conversational dynamics that lead to or subvert effective collaboration, and (c) needing to help principals become more aware of their role in helping to establish clarity of purpose and appropriate levels of autonomy, so that teams may engage in work that leads to effective and innovative problem-finding and problem-solving activities.
Effect of obesity on inpatient rehabilitation outcomes following total knee arthroplasty
Authors: Vincent Heather K , Vincent Kevin R , Lee Laura W , Alfano Alan P 
Published: February 2007

Objectives: To examine obesity effects on outcomes following inpatient rehabilitation in patients following primary total knee arthroplasty or revision total knee arthroplasty. Design: Retrospective, comparative study. Setting: Fifty-bed, university-affiliated rehabilitation hospital. Patients: Obese (N = 139; body mass index >30 kg/m2) and non-obese (N = 146; body mass indexB <30 kg/m2) total knee arthroplasty patients. Participants were further stratified based on total knee arthroplasty type, primary and revision for a total of four groups. Intervention: Interdisciplinary inpatient rehabilitation. Main measures: Range of motion, length of stay, Functional Independence Measure (FIM) scores, FIM efficiency scores, total and daily hospital charges, and discharge disposition location. Results: Range of motion and FIM scores improved from admission to discharge in both obese and non-obese patients regardless of total knee arthroplasty type. FIM efficiency was lower in revision than primary total knee arthroplasty (2.8 versus 3.6 patients/day; P < 0.005) but not different between obese and non-obese groups. Total hospital charges were lower for the primary than for the revision patients (P < 0.05), but were directly related with body mass index (r = 0.140, P < 0.05). Discharge disposition locations were not different among groups. Conclusion: Rehabilitation teams can expect comparable gains between obese and non-obese patients following total knee arthroplasty, but at a greater expense.
Group and home-based tai chi in elderly subjects with knee osteoarthritis: a randomized controlled trial
Authors: Brismée Jean-Michel , Paige Robert L , Chyu Ming-Chien , Boatright Julie D , Hagar James M , McCaleb Joseph A , Quintela Mauricio M , Feng Du , Xu Ke T , Shen Chwan-Li 
Published: February 2007

Objective: To evaluate the effects of tai chi consisting of group and home-based sessions in elderly subjects with knee osteoarthritis. Design: A randomized, controlled, single-blinded 12-week trial with stratification by age and sex, and six weeks of follow-up. Setting: General community. Participants: Forty-one adults (709 / 9.2 years) with knee osteoarthritis. Interventions: The tai chi programme featured six weeks of group tai chi sessions, 40 min/session, three times a week, followed by another six weeks (weeks 7 -12) of home-based tai chi training. Subjects were requested to discontinue tai chi training during a six-week follow-up detraining period (weeks 13-18). Subjects in the attention control group attended six weeks of health lectures following the same schedule as the group-based tai chi intervention (weeks 0 -6), followed by 12 weeks of no activity (weeks 7-18). Main outcome measures: Knee pain measured by visual analogue scale, knee range of motion and physical function measured by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were recorded at baseline and every three weeks throughout the 18-week study period. Data were analysed using a mixed model ANOVA. Results: The six weeks of group tai chi followed by another six weeks of home tai chi training showed significant improvements in mean overall knee pain (P = 0.0078), maximum knee pain (P = 0.0035) and the WOMAC subscales of physical function (P = 0.0075) and stiffness (P = 0.0206) compared to the baseline. No significant change of any outcome measure was noted in the attention control group throughout the study. The tai chi group reported lower overall pain and better WOMAC physical function than the attention control group at weeks 9 and 12. All improvements disappeared after detraining.
Stress in caregivers of aphasic stroke patients: a randomized controlled trial
Authors: Draper Brian , Bowring Greg , Thompson Claire , Van Heyst Jocelyn , Conroy Philip , Thompson Julie 
Published: February 2007

Background: Communication difficulties due to aphasia following stroke are particularly stressful to caregivers. Objective: To examine the impact of a psychoeducation programme on caregivers’ burden and stress and communication between the caregiver and aphasic stroke patient. Design: Randomized wait-list controlled trial with immediate or three-month delayed treatment. Setting: Three public hospital rehabilitation services in Sydney, Australia. Subjects: Thirty-nine caregivers of aphasic stroke patients, up to 12 months post stroke: 19 given immediate treatment and 20 in a delayed treatment control group. Interventions: Four-session weekly caregiver programme that included elements of education, support and communication skills conducted by a speech pathologist, social worker and clinical psychologist. Main measures: The General Health Questionnaire (GHQ) was used to measure caregiver stress, the Relatives’ Stress Scale was used to measure caregiver burden and a communication questionnaire was designed specifically for this project. Results: Thirty-one caregivers completed the study. Caregivers in the immediate treatment group had significant reductions in GHQ measured stress (GHQ mean (SD) at baseline= 6.26 (5.67), GHQ post treatment 3.21 (SD 4.20), P = 0.006). There was no improvement in wait-listed caregivers. Improvement was not maintained at three-month follow-up. There were no significant effects of the programme on communication skills or on caregiver burden. Conclusions: Stroke caregiver support, education and training programmes have short-term effects on caregiver stress levels but are likely to require ongoing involvement to maintain their effect.
Repair Response of the Inner and Outer Regions of the Porcine Meniscus in Vitro
Authors: Hennerbichler Alfred , Moutos Franklin T. , Hennerbichler Diana , Weinberg J. Brice , Guilak Farshid 
Published: February 2007

Background The menisci are essential intra-articular structures that contribute to knee function, and meniscal injury or loss is associated with joint degeneration. Tears of the outer vascularized zone have a greater potential for repair than do tears in the inner avascular region. Objective and Hypothesis Develop an in vitro explant model to examine the hypothesis that differences exist in the intrinsic repair response between the outer and inner region of the meniscus. Study Design Controlled laboratory study. Methods Cylindrical explants were harvested from the outer one third and inner two thirds of medial porcine menisci. To simulate a full-thickness defect, a central core was removed and reinserted immediately. Explants were cultured for 2, 4, or 6 weeks, and meniscal healing was investigated using mechanical testing, histologic analysis, and fluorescence confocal microscopy. Results Over the 6-week culture period, meniscal explants exhibited migration of cells into the repair site, followed by increased tissue formation that bridged the interface. The repair strength increased significantly over time, with no differences between the 2 regions. Conclusion The findings show that explants from the avascular inner zone and vascular outer zone of the meniscus exhibit similar healing potential and repair strength in vitro. Clinical Relevance These findings support the hypothesis that the regional differences in meniscal repair observed clinically are owed to the additional vascular supply of the outer meniscus rather than intrinsic differences between the extracellular matrix and cells from these 2 areas.
Prospective clinical and electrophysiological follow-up on a multiple sclerosis population treated with interferon beta-1 a
Authors: Feuillet L. , Pelletier J. , Suchet L. , Rico A. , Ali Cherif A. , Pouget J. , Attarian S. 
Published: February 2007

Objective To analyse transcranial magnetic stimulation (TMS) variables in a prospective six-month follow-up pilot study on patients suffering from relapsing-remitting multiple sclerosis (RRMS), satisfying inclusion criteria for interferon (IFN) beta-1a treatment. Background So far, no predictive factors are available as to the course of RRMS treated with IFN beta-1 a. Design/methods Fifteen RRMS patients were studied before (month 0 (M0)) and after IFN beta-1a onset (M3, M6). The parameters analysed were motor functional score (mFS), Expanded Disability Status Scale (EDSS), and TMS variables - central motor conduction time (CMCT) and amplitude ratio (AR). Results Four of the six patients with no motor signs at inclusion, subsequently showed signs of pyramidal dysfunction. All had abnormal M0_TMS variables. The number of M0_TMS abnormalities per patient was greatest in the group that showed mFS worsening, and was significantly correlated with M6_EDSS. The M0_CMCT was significantly correlated with M6_EDSS. During follow-up, the number of patients with abnormal TMS variables decreased from 12/15 to 4/15, and the total number of abnormalities decreased from 33.3 to 16.7%. Conclusions TMS variables might be predictive of disease progression. The improvement observed here in the TMS variables may reflect an improvement in MS patients undergoing IFN beta treatment. Multiple Sclerosis 2007; 13: 348-356. http://msj.sagepub.com
Locomotor training using body weight support on a treadmill improves mobility in persons with multiple sclerosis: a pilot study
Authors: Giesser Barbara , Beres-Jones Janell , Budovitch Amy , Herlihy Elise , Harkema Susan 
Published: February 2007

Rationale The purpose of this protocol was to investigate the potential benefits and tolerability of locomotor training using body weight support on a treadmill (LTBWST) in persons with multiple sclerosis (MS). Methods Four persons with primarily spinal cord MS and severely impaired ambulation (Expanded Disability Status Scale score 7.0–7.5) were enrolled in LTBWST. Subjects completed an average of 40 training sessions over several months. Results Subjects showed improvement in muscle strength, spasticity, endurance, balance, walking speed, and quality of life at the end of the training sessions, and could tolerate training without fatigue or other adverse effects. Conclusions LTBWST is well tolerated by persons with MS and may produce improvements in parameters related to functional mobility. Multiple Sclerosis 2007; 13: 224–231. http://msj.sagepub.com
Normal-appearing grey and white matter T1 abnormality in early relapsing–remitting multiple sclerosis: a longitudinal study
Authors: Davies Gr , Hadjiprocopis A , Altmann DR , Chard Dt , Griffin Cm , Rashid W , Parker Gj , Tofts Ps , Kapoor R , Thompson Aj , Miller Dh 
Published: February 2007

Objective To investigate the presence and evolution of T1 relaxation time abnormalities in normal-appearing white matter (NAWM) and grey matter (GM), early in the course of relapsing–remitting multiple sclerosis (MS). Methods Twenty-three patients with early relapsing–remitting MS and 14 healthy controls were imaged six monthly for up to three years. Mean follow-up was 26 months for MS patients and 24 months for controls. Dual-echo fast-spin echo and gradient-echo proton-density and T1-weighted data sets (permitting the calculation of a T1 map) were acquired in all subjects. GM and NAWM T1 histograms were produced and a hierarchical regression model was used to investigate changes in T1 over time. Results At baseline, significant patient-control differences were seen, both in NAWM (P = 0.001) and in GM (P = 0.01). At follow-up, there was no evidence for a serial change in either mean T1 or peak-location for either NAWM or GM. There was weak evidence for a decline in patient NAWM peak-height and also evidence for a decline in control GM peak-height. Conclusion There are significant and persistent abnormalities of NAWM and GM T1 in early relapsing-remitting MS. Further studies should address whether such T1 measures have a role in prognosis or therapeutic monitoring. Multiple Sclerosis 2007; 13:169–177. http://msj.sagepub.com
Interferon beta preparations for the treatment of multiple sclerosis patients differ in neutralizing antibody seroprevalence and immunogenicity
Authors: Sominanda A , Rot U , Suoniemi M , Deisenhammer F , Hillert J , Fogdell-Hahn A 
Published: February 2007

Development of neutralizing antibodies (NAbs) reduces the clinical efficacy of interferon beta (IFNβ) treatment in multiple sclerosis (MS) patients. The aim of this study was to evaluate NAb seroprevalence (frequency of patients with NAbs) and immunogenicity (titer levels) of IFNβ preparations in a clinical setting. We analysed 1115 consecutive MS patients, treated with one of the three available IFNβ preparations, for an average of 40 months (1 – 120 months), for the presence of NAbs with the MxA protein induction assay. Overall, 32% of patients were positive for NAbs with neutralizing titers above 10. The frequency of NAbs, ie, the seroprevalence, was 13% in Avonex-treated patients, 43% for Betaferon, 39% for Rebif22 and 30% for Rebif44. In addition, the potential to induce high titer levels, ie, the immunogenicity, was observed to differ between preparations. Avonex, showing the lowest seroprevalence, also showed low immunogenicity and typically induced low titers. Betaferon, showing the highest seroprevalence when inducing NAbs, induced lower titers compared to Rebif22 and Rebif44. Treatment duration over five years only marginally correlated with decreased seroprevalence and titer levels. In conclusion, NAbs to IFNβ are common in a clinical setting and the IFNβ preparations differ not only in NAb seroprevalence, but also in immunogenicity. Multiple Sclerosis 2007; 13: 208–214. http://msj.sagepub.com
Coping and quality of life in one hundred and thirty five subjects with multiple sclerosis
Authors: Montel S.R. , Bungener C. 
Published: February 2007

Introduction and objective The aim of this study was to compare coping strategies and quality of life (QoL) in multiple sclerosis (MS), as they relate to the course of the disease (relapsing-remitting (RR), secondary progressive (SP), primary progressive (PP)), while taking depression and anxiety into account. Methods A total of 135 MS subjects were seen for a semi-structured interview in order to collect socio-demographic and clinical information, after which there was an assessment of their mental and cognitive states (Mini International Neuropsychiatric Interview (MINI), Montgomery and Asberg Depression Rating Scale (MADRS), Depressive Mood Scale (EHD), Hamilton Anxiety (HAMA), Frontal Assessment Battery (FAB)). All subjects then completed three self-report questionnaires; two about coping strategies (Ways of Coping Checklist (WCC), Coping with Health, Injuries and Problems Scale (CHIP)) and one about QoL (SEP59). Results The mental health (depression and anxiety) and the psychological and social dimensions of QoL were relatively unaffected. However, after controlling for age and disability, the disease course had a strong effect on both mental health and QoL, with the poorest condition for SPMS and the best condition for PPMS. The SPMS patients tend to use emotional coping strategies extensively, while the PPMS patients use more instrumental strategies. Discussion Our study clearly demonstrated that psychological and social well-being were substantially affected by the disease course. These results encourage us to develop interventions focused on coping strategies and which are better adapted to individual patients. Multiple Sclerosis 2007; 13: 393- 401. http://msj.sagepub.com
On Gearksutite at Gingin, Western Australia
Authors: Simpson Edward S. 
Published: February 2007

SummaryA description is given of the occurrence of gearksutite under novel conditions, viz. in Cretaceous greensand, at Gingin in Western Australia. Some additions are made to the previously known physical and chemical properties of the mineral and a new suggestion is put forward as to its constitution. Its genesis is discussed and theories put forward to account for its origin under the previously known and newly discovered conditions.
Transgenic and gene-targeted mice as models for chronic obstructive pulmonary disease: Fig. 1—
Authors: Shapiro S. D. 
Published: February 2007

Animal models play an important role in the understanding of the pathogenesis of chronic obstructive pulmonary disease (COPD). The applicability of findings to human COPD depends upon several factors, including the disease model, and similarities in mouse structure and function between species.There are many examples in the literature of transgenic mice that have contributed to the understanding of COPD. Several studies demonstrate the complexity of inflammatory networks and how unexpected findings in animal models have led to the search for new potential mediators in human disease.Gene-targeting studies into α1-antitrypsin (α1-AT) and emphysema in mice have demonstrated that the genetic locus for α1-AT in mice is very complex and that the loss of one gene is lethal in embryo lung development. This underlines the differences between mice and humans that limit the ability to translate between systems in some instances. Gene targeting has also highlighted complex roles for transforming growth factor-β in COPD and has been used to determine important molecules and pathways in COPD.Both transgenic and gene-targeted models suffer limitations and their applicability to human chronic obstructive pulmonary disease may be dependant on several factors, some of which are still being learnt. The more that is known about similarities and differences, the better the knowledge will be that is gained to develop for chronic obstructive pulmonary disease.
Liver dysfunction after lung recruitment manoeuvres during pressure-controlled ventilation in experimental acute respiratory distress
Authors: Kredel Markus , Muellenbach Ralf M , Brock Robert W , Wilckens Hans-Hinrich , Brederlau Joerg , Roewer Norbert , Wunder Christian 
Published: February 2007

Abstract
Introduction
Consequences of lung recruitment with prolonged high positive end-expiratory pressure (PEEP) ventilation for liver function are unclear. We therefore investigated liver dysfunction during two different ventilation treatment regimens of experimental acute respiratory distress syndrome.

Methods
Sixteen anaesthetised juvenile pietrain pigs were ventilated in the pressure-controlled mode (PCV) with an inspiratory fraction of oxygen (FiO2) of 1.0, a respiratory frequency of 30 per minute, a tidal volume of 6 ml/kg, and a PEEP of 5 cm H2O. After lung injury was induced by repeated pulmonary lavage with normal saline, animals were randomly assigned into two groups (n = 8 each) for a 24-hour trial: PCV (unchanged ventilation) and PCV with recruitment (PCV+R) (starting with a sustained inflation of 50 cm H2O for 1 minute, the ventilation was continued while increasing PEEP in increments of 3 cm H2O every 15 minutes as long as arterial oxygen tension [PaO2] improved). After recruitment, FiO2 was reduced to 0.4 and the PEEP was lowered every 15 minutes until PaO2 decreased to 12.0 to 14.7 kPa (90 to 110 torr). Serum levels of hyaluronic acid (HA), routine liver serum markers, and plasma disappearance rate of indocyanine green (ICG) were tested before and after lung injury, and 6 and 18 hours after randomisation. Liver serum markers were also tested at 24 hours. Paraffin sections of liver tissue stained by haematoxylin and eosin were made after euthanisation.

Results
The PCV+R group exhibited more polymorphonuclear neutrophils and lymphocytes in the liver sinusoids: median score (interquartile range) of 1.5 (1.4 to 1.5) compared to 0.9 (0.7 to 1.1) (p = 0.01). Elevation of bilirubin, aspartate aminotransferase, and lactate dehydrogenase was more prominent in the PCV+R group. Plasma disappearance rate of ICG indicated no liver dysfunction. HA levels in the PCV+R group gradually increased and were significantly higher (p < 0.001) at 6 and 18 hours with 59 (57 to 64) and 75 (66 to 84) ng/ml, respectively, than in the PCV group with 34 (32 to 48) and 41 (38 to 42) ng/ml, respectively.

Conclusion
The PCV+R group showed a more prominent inflammatory reaction in their liver sinusoids accompanied by increased serum levels of liver enzymes and HA. Therefore, recruitment with higher PEEP levels for treatment of respiratory failure might lead to liver dysfunction.