bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerrahi duman: Ameliyathanede çalışan sağlık profesyonellerine etkisi ve alınan önlemlerin incelenmesi
Authors: Dikmen Aydın Yeşim , Gürkan Aysel , Kırtıl İnci 
Published: April 2024

Amaç: Ameliyathanede çalışan sağlık profesyonellerine cerrahi dumanın etkilerini ve alınan koruyucu önlemleri belirlemektir. Yöntem: Tanımlayıcı türdeki çalışma 18 Şubat-18 Nisan 2019 tarihleri arasında İstanbul ilinde yedi eğitim ve araştırma hastanesinin ameliyathanelerinde çalışan 380 cerrah, hemşire ve anestezi uzmanı/anestezi teknisyeni ile yürütüldü. Veriler, katılımcıların bireysel ve mesleki özellikleri, cerrahi dumandan etkilenme durumları ve alınan koruyucu önlemleri belirlemeye yönelik literatüre dayalı oluşturulan veri toplama formu ile elde edildi. Verilerin değerlendirilmesinde tanımlayıcı istatistiksel yöntemler (sayı, yüzde, ortalama ve standart sapma) ve ki-kare testi kullanıldı. Anlamlılık p˂0.05 olarak kabul edildi. Bulgular: Katılımcıların yaş ortalaması 31.41±8.03 (min.19-maks.65) yıl olup %51.8’i hemşire, %24.7’si cerrah, %23.5’i anestezi uzmanı/anestezi teknisyeniydi. Katılımcıların %95’inin cerrahi dumana maruz kaldığı, cerrahi dumana maruz kalma açısından meslek, çalışılan ameliyat odası ve ameliyathanede çalışma süresine göre anlamlı fark olduğu bulundu. Cerrahi dumanın solunmasına bağlı katılımcıların en fazla oranda (%20.6) baş ağrısı deneyimlediği ve cerrahi dumandan korunmaya yönelik önlemler arasında en fazla oranda cerrahi maskeyi (%90.2) kullandıkları belirlendi. Sonuç: Çalışma bulguları ameliyathanede çalışan sağlık profesyonellerinin yüksek oranda cerrahi dumana maruz kaldığını ve buna bağlı çeşitli semptomlar deneyimlediklerini, birimlerinde/kurumlarında cerrahi dumandan korunmaya yönelik önlemlerin yetersiz olduğunu gösterdi. Konuya ilişkin farkındalığın arttırılması için eğitim ve çalışmaların yapılması ve cerrahi dumandan korunmaya yönelik yönergelerin uygulanması önerilir.
Strategi Kemandirian Berwirausaha Santri Perspektif Etika Bisnis Islam
Authors: Tamalla Alyya Noor , Fauzi Ahmad 
Published: April 2024

Kemandirian termasuk sebagai sumber tenaga kerja untuk menghasilkan produk yang berkualitas, baik berupa materi maupun barang dan jasa. Sebagai seorang individu, seorang wirausahawan juga harus mempunyai sesuatu hal yang utama mengenai perilaku, sikap dan kebiasaan yang tumbuh dan berkembang yang dapat dibentuk oleh suatu kondisi lingkungan maupun pengalaman dalam berwirausaha. Kegiatan berwirausaha di Pondok Pesantren Darussalam Lirboyo meliputi koperasi, kantin, jual beli online. Penelitian ini menggunakan jenis penelitian kualitatif dengan pendekatan studi kasus. Objek dalam penelitian ini adalah kemandirian berwirausaha santri perspektif etika bisnis Islam studi kasus pondok pesantren Putri Unit Darussalam Lirboyo. Metode pengumpulan data yang digunakan dalam penelitian ini adalah dengan melakukan wawancara dan dokumentasi. Hasil penelitian menunjukkan bahwa Proses pelaksanaan kemandirian kewirausahaan yang terdapat di Pondok Pesantren Unit Darussalam Lirboyo Kota Kediri, hal ini dapat dibuktikan dengan dibentuknya usaha yang dijalankan. didalam pondok pesantren meliputi kantin, koperasi, dan kegiatan jual beli online. Pelaksanaan Kemandirian Berwirausaha Santri di Pondok Pesantren Putri Unit Darussalam Lirboyo Kediri Perspektif Etika Bisnis Islam. Dibuktikan dengan tetap memperhatikan Prinsip, Manajemen, Marketing, Harga yang digunakan sebagai panduan dalam menjalankan sebuah bisnis atau usahanya.
Entitas Pembiayaan Sindikasi (Al Tamwil Al Mashrifi Al Mujammaâ€™) Perbankan Syariah Berdasarkan Fatwa DSN-MUI Nomor 91/2014
Authors: Jamaluddin Jamaluddin 
Published: April 2024

Perbankan Syariah merupakan unit sistem ekonomi Islam yang beroperasi dengan doktrin dan larangan terhadap praktik riba, yang memiliki peran strategis dalam meningkatkan kesejahteraan umat, melalui proses intermediasi kegiatan penghimpunan, penyaluran dana dan penyadiaan jasa keuangan lainnya, berdasarkan prinsip syariah. Kemampuan survival perbankan syariah di era krisis, telah menarik banyak perhatian para banker konvensional yang kemudian membuka kantor-kantor cabang bank Islam, yang sekarang melebur (mager) menjadi satu bank, yang disebut Bank Syariah Indonesia (BSI). Pembiayaan sindikasi yang dilakukan antara Lembaga Keuangan Syariah (LKS) dengan Lembaga Keuangan Konvensional (LKK) dibolehkan dengan beberapa syarat rekening, dokumen kontrak dan dokumen-dokumen pendukung lainya harus di pisahkan dan tidak dapat disatukan dengan lembaga keuangan syariah, agar tidak tercampur antara yang halal dengan yang ribawi. Metode penelitian ini berdasarkan deskriptif kualitatif dengan pendekatan library research. Sumber penelitian ini hasil kajian buku-buku, jurnal penelitian, kitab kuning dan sumber lain. Teknik pengumpulan data referensi buku, dokumentasi dan literatur lain yang ada korelasinya dengan judul makalah jurnal ini. Berdasarkan hasil pengelolaan data, penelitian ini menunjukan bahwa pembiayaan sindikasi sesuai dengan Fatwa MUI Nomor 91/2014 tentang pembiayaan sindikasi (al-tamwil al-mashrifi al-mujammaâ€™) terhadap perjanjian bagi hasil proyek.
Pengentasan Ekonomi Single Parent Berbasis Pengelolaan Zakat
Authors: Alfan Aufa Muh. , Yustafad Muh. , Fatmah Fatmah 
Published: April 2024

Penelitian ini dalam bingkai besar pengelolaan manajemen zakat. Manajemen pengelolaan zakat yang produktif dapat meningkatkan taraf hidup dan perekonomian perempuan single parent. Perempuan single parent banyak mengalami kendala perekonomian karena selama berkeluarga menggantungkan hidup pada hasil kerja pasangan. Penelitian ini dilakukan di Lazisnu Gondang Legi Plosoklaten Kediri yang telah berupaya melakukan pengelolaan zakat dengan orientasi peningkatan prekonomian perempuan single parent. Penelitian ini adalah penelitian kualitatif dengan analisis pendekatan teori manajemen. Hasil penelitian menunjukkan bahwa pengelolaan zakat produktif di Lazisnu Gondang Legi Plosoklaten Kediri sudah menggunakan teori manajemen secara menyeluruh
The effects of acute exercise on long-term episodic memory: a systematic review and meta-analysis
Authors: Qazi Ahmed S. , Schmid Daphne , Gridley Nicole , Lambourne Kate , Daly-Smith Andrew J. , Tomporowski Phillip D. 
Published: April 2024

Research findings reveal a relationship between acute bouts of exercise and procedural/declarative memory. Prior systematic reviews report small/moderate effects of acute exercise on episodic long-term declarative memory. A somewhat overlooked issue is the influence of exercise on specific types of episodic memory processing. The primary focus of this systematic review and meta-analysis was to evaluate the effects of acute bouts of exercise prior to, during, and following encoding on free-, cued-recall, and recognition episodic memory. PubMed, Scopus, and EBSCO databases were entered, and 42 experiments were subject to meta-analysis. Exercise prior to encoding improved memory (d = 0.23) and affected free-recall (d = 0.40) tests of memory more than cued-recall (d = 0.08) or recognition (d = −0.06) memory. Exercise following encoding improved memory (d = 0.33) and affected recognition (d = 0.62) memory more than free- (d = 0.19) or cued-recall (d = 0.14) memory. Exercise during encoding did not influence memory (d = −0.04). Moderator analyses revealed that exercise before encoding impacted memory differentially on the basis of age, exercise type, and test-timing. When exercise occurred after encoding, age and exercise type, but not timing of the test influenced memory performance. Exercise before and after encoding has selective effects on episodic memory. Additional experiments that evaluate how bouts of exercise influence memory encoding are warranted.Systematic review registrationPROSPERO, identifier CRD42020202784.
Characterization of myocardial injury phenotype by thermal liquid biopsy
Authors: Lidani Karita C. F. , Buscaglia Robert , Trainor Patrick J. , Tomar Shubham , Kaliappan Alagammai , DeFilippis Andrew P. , Garbett Nichola C. 
Published: April 2024

Background and aimsWith the advent and implementation of high-sensitivity cardiac troponin assays, differentiation of patients with distinct types of myocardial injuries, including acute thrombotic myocardial infarction (TMI), acute non-thrombotic myocardial injury (nTMi), and chronic coronary atherosclerotic disease (cCAD), is of pressing clinical importance. Thermal liquid biopsy (TLB) emerges as a valuable diagnostic tool, relying on identifying thermally induced conformational changes of biomolecules in blood plasma. While TLB has proven useful in detecting and monitoring several cancers and autoimmune diseases, its application in cardiovascular diseases remains unexplored. In this proof-of-concept study, we sought to determine and characterize TLB profiles in patients with TMI, nTMi, and cCAD at multiple acute-phase time points (T 0 h, T 2 h, T 4 h, T 24 h, T 48 h) as well as a follow-up time point (Tfu) when the patient was in a stable state.MethodsTLB profiles were collected for 115 patients (60 with TMI, 35 with nTMi, and 20 with cCAD) who underwent coronary angiography at the event presentation and had subsequent follow-up. Medical history, physical, electrocardiographic, histological, biochemical, and angiographic data were gathered through medical records, standardized patient interviews, and core laboratory measurements.ResultsDistinctive signatures were noted in the median TLB profiles across the three patient types. TLB profiles for TMI and nTMi patients exhibited gradual changes from T0 to Tfu, with significant differences during the acute and quiescent phases. During the quiescent phase, all three patient types demonstrated similar TLB signatures. An unsupervised clustering analysis revealed a unique TLB signature for the patients with TMI. TLB metrics generated from specific features of TLB profiles were tested for differences between patient groups. The first moment temperature (TFM) metric distinguished all three groups at time of presentation (T0). In addition, 13 other TLB-derived metrics were shown to have distinct distributions between patients with TMI and those with cCAD.ConclusionOur findings demonstrated the use of TLB as a sensitive and data-rich technique to be explored in cardiovascular diseases, thus providing valuable insight into acute myocardial injury events.
Tumor lymphangiogenesis index reveals the immune landscape and immunotherapy response in lung adenocarcinoma
Authors: Yang Weichang , Wu Zhijian , Cai Shanshan , Li Zhouhua , Wang Wenjun , Wu Juan , Luo Hongdan , Ye Xiaoqun 
Published: April 2024

BackgroundLymphangiogenesis (LYM) has an important role in tumor progression and is strongly associated with tumor metastasis. However, the clinical application of LYM has not progressed as expected. The potential value of LYM needs to be further developed in lung adenocarcinoma (LUAD) patients.MethodsThe Sequencing data and clinical characteristics of LUAD patients were downloaded from The Cancer Genome Atlas and GEO databases. Multiple machine learning algorithms were used to screen feature genes and develop the LYM index. Immune cell infiltration, immune checkpoint expression, Tumor Immune Dysfunction and Exclusion (TIDE) algorithm and drug sensitivity analysis were used to explore the correlation of LYM index with immune profile and anti-tumor therapy.ResultsWe screened four lymphangiogenic feature genes (PECAM1, TIMP1, CXCL5 and PDGFB) to construct LYM index based on multiple machine learning algorithms. We divided LUAD patients into the high LYM index group and the low LYM index group based on the median LYM index. LYM index is a risk factor for the prognosis of LUAD patients. In addition, there was a significant difference in immune profile between high LYM index and low LYM index groups. LUAD patients in the low LYM index group seemed to benefit more from immunotherapy based on the results of TIDE algorithm.ConclusionOverall, we confirmed that the LYM index is a prognostic risk factor and a valuable predictor of immunotherapy response in LUAD patients, which provides new evidence for the potential application of LYM.
Effect of air sterilizers in an outpatient clinic at a tertiary university hospital
Authors: Lee Dong Hoon , Yeom Sujung , Lee Hwa Sin , Cho Hyong-Ho 
Published: April 2024

BackgroundAfter the COVID-19 outbreak, interest in airborne virus infections has increased. We considered ways to reduce the risk of infection to other people by inactivating the virus before it is inhaled into the heating, ventilation, and air conditioning (HVAC) systems. We installed a recently developed air sterilizer in the newly remodeled outpatient clinic of a tertiary university hospital and confirmed its effectiveness.MethodsAfter remodeling the ENT outpatient clinic at Chonnam National University Hospital, 15 KOKKOS air sterilizers (Bentech Frontier Co., Ltd., Gwangju, Korea) were installed. Total culturable microorganisms (TCMs) and volatile organic compounds (VOCs) were measured in five separate inspection areas three days before installation, 2 weeks after installation, and 4 weeks after installation.ResultsAfter measurement of TCMs, improvement in air quality occurred 2 weeks after air sterilizer instatement at all timepoints except inspection area 5, and further improvement was achieved after 4 weeks (p &lt; 0.05). After assessment of VOCs, improvement occurred 4 weeks after air sterilizer connection at all points (p &lt; 0.05).ConclusionKOKKOS air sterilizers are effective in improving air quality in an outpatient clinic at a tertiary university hospital.
Gut microbiome changes in mouse, Mongolian gerbil, and hamster models following Clostridioides difficile challenge
Authors: Wan Shuangshuang , You Peijun , Shi Qikai , Hu Hui , Zhang Lu , Chen Leyang , Wu Ziyi , Lin Shan , Song Xiaojun , Luo Yongneng , Wang Yaxuan , Ju Feng , Jin Dazhi , Chen Yu 
Published: April 2024

IntroductionClostridioides difficile infection (CDI), as well as its etiology and pathogenesis, have been extensively investigated. However, the absence of suitable CDI animal models that reflect CDI symptoms and the associated gut microbiome changes in humans has limited research progress in this field. Thus, we aimed to investigate whether Mongolian gerbils, which present a range of human pathological conditions, can been used in studies on CDI. Methods: In this study, we infected Mongolian gerbils and two existing CDI model animals, mice and hamsters, with the hypervirulent ribotype 027 C. difficile strain, and comparatively analyzed changes in their gut microbiome composition via 16S rRNA gene sequencing.MethodsIn this study, we infected Mongolian gerbils and two existing CDI model animals, mice and hamsters, with the hypervirulent ribotype 027 C. difficile strain, and comparatively analyzed changes in their gut microbiome composition via 16S rRNA gene sequencing.ResultsThe results obtained showed that C. difficile colonized the gastrointestinal tracts of the three rodents, and after the C. difficile challenge, C57BL/6J mice did not manifest CDI symptoms and their intestines showed no significant pathological changes. However, the hamsters showed explosive intestinal bleeding and inflammation and the Mongolian gerbils presented diarrhea as well as increased infiltration of inflammatory cells, mucus secretion, and epithelial cell shedding in their intestinal tissue. Further, intestinal microbiome analysis revealed significant differences with respect to intestinal flora abundance and diversity. Specifically, after C. difficile challenge, the Firmicutes/Bacteroidetes ratio decreased for C57BL/6J mice, but increased significantly for Mongolian gerbils and hamsters. Furthermore, the abundance of Proteobacteria increased in all three models, especially in hamsters, while that of Verrucomicrobia only increased significantly in C57BL/6J mice and Mongolian gerbils. Our results also indicated that differences in the relative abundances of Lactobacillaceae and Akkermansia were primarily responsible for the observed differences in response to C. difficile challenge.ConclusionBased on the observed responses to C. difficile challenge, we concluded for the first time that the Mongolian gerbil could be used as an animal model for CDI. Additionally, the taxa identified in this study may be used as biomarkers for further studies on CDI and to improve understanding regarding changes in gut microbiome in CDI-related diseases.
An IL-17A-centric response to Epstein-Barr virus DNA mediated by dendritic Cell-T cell interactions
Authors: Shehab Marwa , Hussein Hadi , Fadlallah Sukayna , Rahal Elias A. 
Published: April 2024

Introduction: The Epstein-Barr virus has been associated with a considerable number of autoimmune diseases. We have previously demonstrated that EBV DNA enhances the production of IL-17A, a pro-inflammatory cytokine, via endosomal Toll-like receptor signalling.Methods: We used RNA-seq to analyze the transcriptional profile of mouse immune cells treated with EBV DNA.Results: We observed that EBV DNA upregulates an IL-17A-centric network of mediators. Ensemble Gene Set Enrichment Analysis (EGSEA) showed enriched expression of sets involved in inflammatory responses including IFNγ and TNF-α-associated pathways as well as proinflammatory diseases. On the other hand, while macrophages and B cells were somewhat able to induce an IL-17A response from T cells to EBV DNA, they were less potent than dendritic cells. EBV virions were also capable of eliciting the production of inflammatory mediators from dendritic cell-T cell cultures largely mirroring responses to the viral DNA.Conclusions: Given the wide prevalence of EBV in the population, our analyses reveal a network of mediators and cell types that may serve as therapeutic targets in a large proportion of people affected by autoimmune diseases.
A novel speech analysis algorithm to detect cognitive impairment in a Spanish population
Authors: Kaser Alyssa N. , Lacritz Laura H. , Winiarski Holly R. , Gabirondo Peru , Schaffert Jeff , Coca Alberto J. , Jiménez-Raboso Javier , Rojo Tomas , Zaldua Carla , Honorato Iker , Gallego Dario , Nieves Emmanuel Rosario , Rosenstein Leslie D. , Cullum C. Munro 
Published: April 2024

ObjectiveEarly detection of cognitive impairment in the elderly is crucial for diagnosis and appropriate care. Brief, cost-effective cognitive screening instruments are needed to help identify individuals who require further evaluation. This study presents preliminary data on a new screening technology using automated voice recording analysis software in a Spanish population.MethodData were collected from 174 Spanish-speaking individuals clinically diagnosed as cognitively normal (CN, n = 87) or impaired (mild cognitive impairment [MCI], n = 63; all-cause dementia, n = 24). Participants were recorded performing four common language tasks (Animal fluency, alternating fluency [sports and fruits], phonemic “F” fluency, and Cookie Theft Description). Recordings were processed via text-transcription and digital-signal processing techniques to capture neuropsychological variables and audio characteristics. A training sample of 122 subjects with similar demographics across groups was used to develop an algorithm to detect cognitive impairment. Speech and task features were used to develop five independent machine learning (ML) models to compute scores between 0 and 1, and a final algorithm was constructed using repeated cross-validation. A socio-demographically balanced subset of 52 participants was used to test the algorithm. Analysis of covariance (ANCOVA), covarying for demographic characteristics, was used to predict logistically-transformed algorithm scores.ResultsMean logit algorithm scores were significantly different across groups in the testing sample (p &lt; 0.01). Comparisons of CN with impaired (MCI + dementia) and MCI groups using the final algorithm resulted in an AUC of 0.93/0.90, with overall accuracy of 88.4%/87.5%, sensitivity of 87.5/83.3, and specificity of 89.2/89.2, respectively.ConclusionFindings provide initial support for the utility of this automated speech analysis algorithm as a screening tool for cognitive impairment in Spanish speakers. Additional study is needed to validate this technology in larger and more diverse clinical populations.
Episodic memory assessment: effects of sex and age on performance and response time during a continuous recognition task
Authors: Clifford James O. , Anand Sulekha , Tarpin-Bernard Franck , Bergeron Michael F. , Ashford Curtis B. , Bayley Peter J. , Ashford John Wesson 
Published: April 2024

IntroductionContinuous recognition tasks (CRTs) assess episodic memory (EM), the central functional disturbance in Alzheimer’s disease and several related disorders. The online MemTrax computerized CRT provides a platform for screening and assessment that is engaging and can be repeated frequently. MemTrax presents complex visual stimuli, which require complex involvement of the lateral and medial temporal lobes and can be completed in less than 2 min. Results include number of correct recognitions (HITs), recognition failures (MISSes = 1-HITs), correct rejections (CRs), false alarms (FAs = 1-CRs), total correct (TC = HITs + CRs), and response times (RTs) for each HIT and FA. Prior analyses of MemTrax CRT data show no effects of sex but an effect of age on performance. The number of HITs corresponds to faster RT-HITs more closely than TC, and CRs do not relate to RT-HITs. RT-HITs show a typical skewed distribution, and cumulative RT-HITs fit a negative survival curve (RevEx). Thus, this study aimed to define precisely the effects of sex and age on HITS, CRs, RT-HITs, and the dynamics of RTs in an engaged population.MethodsMemTrax CRT online data on 18,255 individuals was analyzed for sex, age, and distributions of HITs, CRs, MISSes, FAs, TC, and relationships to both RT-HITs and RT-FAs.ResultsHITs corresponded more closely to RT-HITs than did TC because CRs did not relate to RT-HITs. RT-FAs had a broader distribution than RT-HITs and were faster than RT-HITs in about half of the sample, slower in the other half. Performance metrics for men and women were the same. HITs declined with age as RT-HITs increased. CRs also decreased with age and RT-FAs increased, but with no correlation. The group over aged 50 years had RT-HITs distributions slower than under 50 years. For both age ranges, the RevEx model explained more than 99% of the variance in RT-HITs.DiscussionThe dichotomy of HITs and CRs suggests opposing cognitive strategies: (1) less certainty about recognitions, in association with slower RT-HITs and lower HIT percentages suggests recognition difficulty, leading to more MISSes, and (2) decreased CRs (more FAs) but faster RTs to HITs and FAs, suggesting overly quick decisions leading to errors. MemTrax CRT performance provides an indication of EM (HITs and RT-HITs may relate to function of the temporal lobe), executive function (FAs may relate to function of the frontal lobe), processing speed (RTs), cognitive ability, and age-related changes. This CRT provides potential clinical screening utility for early Alzheimer’s disease and other conditions affecting EM, other cognitive functions, and more accurate impairment assessment to track changes over time.