bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social impairment in survivors of pediatric brain tumors via reduced social attention and emotion‐specific facial expression recognition
Authors: Fantozzi Peter M. , Anil Ashley , McHugh Sean , Srsich Alannah R. , Zope Manali , Parish‐Morris Julia , Schultz Robert T. , Herrington John , Hocking Matthew C. 
Published: March 2024

AbstractBackground/objectivesSurvivors of pediatric brain tumors (SPBT) experience significant social challenges, including fewer friends and greater isolation than peers. Difficulties in face processing and visual social attention have been implicated in these outcomes. This study evaluated facial expression recognition (FER), social attention, and their associations with social impairments in SPBT.MethodsSPBT (N = 54; ages 7–16) at least 2 years post treatment completed a measure of FER, while parents completed measures of social impairment. A subset (N = 30) completed a social attention assessment that recorded eye gaze patterns while watching videos depicting pairs of children engaged in joint play. Social Prioritization scores were calculated, with higher scores indicating more face looking. Correlations and regression analyses evaluated associations between variables, while a path analysis modeling tool (PROCESS) evaluated the indirect effects of Social Prioritization on social impairments through emotion‐specific FER.ResultsPoorer recognition of angry and sad facial expressions was significantly correlated with greater social impairment. Social Prioritization was positively correlated with angry FER but no other emotions. Social Prioritization had significant indirect effects on social impairments through angry FER.ConclusionFindings suggest interventions aimed at improving recognition of specific emotions may mitigate social impairments in SPBT. Further, reduced social attention (i.e., diminished face looking) could be a factor in reduced face processing ability, which may result in social impairments. Longitudinal research is needed to elucidate temporal associations between social attention, face processing, and social impairments.
Biomimetic mineralization of silicon dioxide onto carbon fiber for elevated interfacial properties and hydrothermal aging resistance of carbon fiber/epoxy composites
Authors: Yan Fei , Wang Junming , Li Gang , Dai Shengtao , Ao Yuhui , Liu Liu 
Published: March 2024

AbstractA carbon fiber‐tannic acid‐silicon dioxide (CF‐TA‐SiO2) reinforcement with a “diatom frustule‐like” structure was built via biomimetic mineralization to boost the performance of carbon fiber/epoxy resin (CF/EP) composites. As a bio‐based polyphenolic compound, TA was used to modulate the mineralization of SiO2, and the easy agglomeration of SiO2 was effectively avoided. The interfacial adhesion of the CF/EP composites was considerably heightened by improving the roughness and wettability of CF as well as by increasing the interfacial interactions between CF and the EP. Compared with the pristine composites, the flexural strength, interlaminar shear strength and interfacial shear strength of the CF‐TA‐SiO2/EP composites increased by 41.2%, 56.6%, and 50.4%, respectively. Moreover, the introduction of Si‐O‐Si and C‐O‐Si bonds at the interface led to a remarkable improvement in the hydrothermal aging resistance. This research provides a novel interfacial design for advanced composites with excellent interfacial properties, which broadens the application of these composites in hygrothermal environments.Highlights
A “diatom frustules‐like” structure was successfully constructed on the CF surface.
This biomimetic mineralization was simple and environmentally friendly.
This method solved the problem of easy agglomeration of SiO2.
The interfacial properties of composites were obviously improved.
The hydrothermal aging resistance of composites was enhanced.
Functionalized hydroxypropyl‐β‐cyclodextrin derivative as a versatile nanovehicle for delivery of paclitaxel
Authors: Liang Na , Yan Caixia , Liu Zhenrong , Hu Wenlong , Jiang Kun , Li Gang , Sun Shaoping 
Published: March 2024

AbstractTo improve the therapeutic efficiency of paclitaxel (PTX) and reduce its toxicity to normal tissues, a novel hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) derivative has been designed and developed. The polymer (bio‐HP‐β‐CD(NAC)‐PLA) is synthesized by modifying HP‐β‐CD with polylactic acid, cysteine, and biotin. Using bio‐HP‐β‐CD(NAC)‐PLA as the carrier, a PTX‐loaded nanoparticulate system is developed by a modified emulsion solvent evaporation method. The optimized drug‐loaded nanoparticles are obtained with a mean diameter of 162.4 nm and drug loading of 16.1%. In vitro drug release study exhibits that PTX is released in a redox‐dependent manner. Cellular uptake study suggests that the bio‐HP‐β‐CD(NAC)‐PLA nanoparticles can be specifically taken up by MCF‐7 cells via the biotin receptor‐mediated endocytosis. In vitro and in vivo anticancer efficacy evaluations demonstrate the superior antitumor activity and negligible toxicity of the PTX‐loaded nanoparticles. It can be concluded that the proposed polymer bio‐HP‐β‐CD(NAC)‐PLA offers a promising drug delivery system for targeted delivery and controlled release of PTX.
Structure and properties evolution of UV crosslinked ultra‐high molecular weight polyethylene fiber during processing
Authors: Dong Tianhong , Niu Fangfang , Qiang Zhe , Wang Xinpeng , Guo Jungu , Wang Yimin , He Yong 
Published: March 2024

AbstractWith the development of heat and creep‐resistant UHMWPE fiber via UV crosslinking, its structure‐properties evolution during processing needs attention. The structures of UHMWPE fiber in different forms, the pre‐oriented yarn (POY), the full stretch yarn (FDY) and UV crosslinked FDY (UVFDY), obtained from our pilot line were systematically studied with differential scanning calorimetry (DSC), wide‐angle X‐ray diffraction (WAXD), small‐angle X‐ray scattering (SAXS), and solid‐state 13C NMR. Additionally, the heat and creep resistance of UVFDY were evaluated by the temperature at break (Tb), glass transition temperature (Tg), time at break (tb) for a given aging temperature, and creep elongation (Lc). The results demonstrated that UVFDY possessed high gel content (89.0%), high crystallinity (84.2%), and high orientation (91.7%). These characteristics caused UVFDY not only with excellent mechanical properties but also process extraordinary heat and creep resistance, especially for its much higher Tb (220 °C), Tg (−75.7 °C) and tb (20 h) while lower Lc (7.8%), comparing with FDY (Tb = 158 °C, Tg = −86.8 °C, tb = 1.3 h and Lc = 38.2%). This work provides insights into the structure‐properties relationship of UVFDY, which will aid in the development of UV crosslinked UHMWPE fiber with better heat and creep resistance.
Design of Vaterite Nanoparticles for Controlled Delivery of Active Immunotherapeutic Proteins
Authors: Nelemans Levi Collin , Choukrani Ghizlane , Ustyanovska‐Avtenyuk Natasha , Wiersma Valerie R , Dähne Lars , Bremer Edwin 
Published: March 2024

AbstractDespite clinical advances in immunotherapy, still many therapeutics cause dose‐limiting (auto)immune‐mediated toxicities. Nanoparticle‐based drug delivery systems (DDS) can improve cancer immunotherapy through site‐specific delivery and controlled release of immunotherapeutics in the tumor microenvironment (TME). However, DDS face several challenges, including unspecific release. To address this, vaterite nanoparticles (VNPs) that selectively release immunotherapeutic proteins at low pH conditions find in the TME, are established previously. In the current study, these VNPs are further modified for active targeting without affecting the loaded protein activity, exemplified with Tumor Necrosis Factor α (TNF). Specifically, VNPs are coated with gelatin, a matrix‐metalloprotease sensitive polymer which provides functional groups for further conjugation. Subsequently, streptavidin is covalently linked to the gelatin shell by amine‐epoxy chemistry, enabling coupling of any biotinylated ligand. Exemplified by biotinylated cetuximab and rituximab, targeted VNPs selectively bind to cells expressing epidermal growth factor receptor (EGFR) or CD20, respectively. Importantly, TNF remains functionally active after the modification steps, as VNP treatment increased ICAM‐1 expression on FaDu cells and activated NFκB signaling in a Jurkat.NFκB‐luciferase cell line model. In conclusion, a targetable vaterite‐based DDS is produced that allows for easy surface modification with any biotinylated ligand that may find broad applications in tumor‐selective immunotherapy.
Supporting the transfer of knowledge in high‐risk major accident environment
Authors: Kryštof David , Adamec Petr , Kotek Luboš , Tichá Zuzana , Trávníček Petr 
Published: March 2024

AbstractA key element in learning from accidents is the skill associated with the transfer of knowledge gained by the operator from historical incidents. These incidents can include accidents and near‐misses that occurred on site or in similar companies outside the plant. Knowledge transfer within the enterprise can be supported by a suitable framework or model that is easily understood by a wide range of people who are interested in the lessons learned from accidents. The application of some of the knowledge transfer models used so far can be quite time consuming and uncomfortable for the participants. For this reason, this paper aims to propose a simple model designed to support knowledge transfer. This model is proposed based on the widely used PDCA (plan‐do‐check‐act) framework. Its use is demonstrated by the case of a major accident that occurred in the Czech Republic. The model can be used not only for learning from major accidents that occur in the subject company but also for learning from near‐misses or events that occurred in the past in similar plants. Thus, the model can easily help in increasing the efficiency of the accident‐learning system in particular.
Hormetic effect induced by Beauveria bassiana in Myzus persicae
Authors: Arinanto Leonhard Satrio , Hoffmann Ary Anthony , Ross Perran Albert , Gu Xinyue 
Published: March 2024

AbstractBACKGROUNDMyzus persicae, a serious sap‐sucking pest of a large variety of host plants in agriculture, is traditionally controlled using chemical insecticides but there is interest in using biopesticides as restrictions are increasingly placed on the use of broad‐spectrum pesticides.RESULTSHere, we show that in Petri dish experiments, high concentrations of the fungal entomopathogen Beauveria bassiana led to rapid mortality of M. persicae, although at a low concentration (1 × 104 conidia mL−1) there is a hormetic effect in which survival and fecundity are enhanced. Hormetic effects persisted across a generation with reduced development time and increased fecundity in the offspring of M. persicae exposed to B. bassiana. The whole‐plant experiment points to a hormetic effect being detected in two out of three tested lines. The impact of these effects might also depend on whether M. persicae was transinfected with the endosymbiont Rickettsiella viridis, which decreases fecundity and survival compared with aphids lacking this endosymbiont. This fecundity cost was ameliorated in the generation following exposure to the entomopathogen.CONCLUSIONAlthough B. bassiana is effective in controlling M. persicae especially at higher spore concentrations, utilization of this entomopathogen requires careful consideration of hormetic effects at lower spore concentrations, and further research to optimize its application for sustainable agriculture is recommended. © 2024 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Utility of thermal remote sensing for evaluation of a high‐resolution weather model in a city
Authors: Hall Thomas W. , Blunn Lewis , Grimmond Sue , McCarroll Niall , Merchant Christopher J. , Morrison William , Shonk Jonathan K. P. , Lean Humphrey , Best Martin 
Published: March 2024

AbstractProgress in high‐resolution numerical weather prediction (NWP) for urban areas will require new modelling approaches and extensive evaluation. Here, we exploit land surface temperature (LST) data from Landsat‐8 to assess 100 m resolution NWP for London (UK) on four cloud‐free days. The LST observations are directional radiometric temperatures with non‐negligible uncertainties. We consider the challenges of informative comparison between the Landsat LST and the NWP scheme's internal characterisation of the complete surface temperature. The LST spatial coverage allows large‐scale observation–model differences to be explored. In one case, obvious spatial artifacts in the NWP surface temperature are observed relative to the Landsat LST. These are found to be related to the NWP's initial method of downscaling of soil moisture using soil properties. Updated model runs have higher spatial correlation between model and Landsat LST. In cases where meteorological conditions favour the formation of horizontal convective rolls, warmer air temperatures associated with updraughts in the mixed layer extend inappropriately to the urban surface. This manifests as warm stripes in the model surface temperature that are not present in the Landsat LST. NWP–Landsat LST differences are larger in more built‐up areas on days nearer summer solstice. This is largely attributed to urban thermal anisotropy, as Landsat preferentially views warmer urban surfaces, whereas the model LST represents all surfaces. We evaluate two approaches to quantify this sampling effect, but further work is needed to fully constrain it and facilitate more informative model evaluation.
Perturbations in human bile acid profiles following drug‐induced liver injury investigated using semitargeted high‐resolution mass spectrometry
Authors: Mireault Myriam , Rose Christopher F. , Karvellas Constantine J. , Sleno Lekha 
Published: March 2024

RationaleAcetaminophen (APAP) overdose is the leading cause of acute liver failure (ALF) in North America. To investigate the effect of drug‐induced liver injury (DILI) on circulating bile acid (BA) profiles, serum from ALF patients and healthy controls were analyzed using a semitargeted high‐resolution mass spectrometry approach to measure BAs in their unconjugated and amidated forms and their glucuronide and sulfate conjugates.MethodsHuman serum samples from 20 healthy volunteers and 34 ALF patients were combined with deuterated BAs and extracted, prior to liquid chromatography high‐resolution tandem mass spectrometry analysis. A mix of 46 standards helped assign 26 BAs in human serum by accurate mass and retention time matching. Moreover, other isomers of unconjugated and amidated BAs, as well as glucuronide and sulfate conjugates, were assigned by accurate mass filtering. In vitro incubations of standard BAs provided increased information for certain peaks of interest.ResultsA total of 275 BA metabolites, with confirmed or putative assignments, were measured in human serum samples. APAP overdose significantly influenced the levels of most BAs, promoting glycine conjugation, and, to a lesser extent, taurine conjugation. When patient outcome was considered, 11 BAs were altered significantly, including multiple sulfated species. Although many of the BAs measured did not have exact structures assigned, several putatively identified BAs of interest were further characterized using in vitro incubations.ConclusionAn optimized chromatographic separation tailored to BAs of ranging polarities was combined with accurate mass measurements to investigate the effect that DILI has on their complex profiles and metabolism to a much wider extent than previously possible. The analysis of complex BA profiles enabled in‐depth analysis of the BA metabolism perturbations in ALF, including certain metabolites related to patient outcomes.
The roles of sex hormones in the pathophysiology of age‐related sarcopenia and frailty
Authors: Hosoi Tatsuya , Yakabe Mitsutaka , Hashimoto Seiji , Akishita Masahiro , Ogawa Sumito 
Published: March 2024

AbstractBackgroundSarcopenia is an age‐related condition characterized by a progressive and systemic decline in skeletal muscle mass, quality, and strength. The incidence of sarcopenia contains sex‐specific aspects, indicating the contribution of sex hormones to its pathophysiology. This review focuses on changing trends in sarcopenia, discusses alterations in definitions and diagnostic criteria, and emphasizes the association between sarcopenia and sex hormones.MethodsA literature search was performed on PubMed for related articles published between 1997 and December 2023 using appropriate keywords.Main Findings (Results)Advances in research have emphasized the significance of muscle quality and strength over muscle mass, resulting in new diagnostic criteria for sarcopenia. Androgens demonstrated anabolic effects on skeletal muscles and played a significant role in the pathophysiology of sarcopenia. In clinical settings, androgen replacement therapy has exhibited certain positive outcomes for treating sarcopenia, despite concerns about potential side effects. Conversely, estrogen is involved in skeletal muscle maintenance, but the detailed mechanisms remain unclear. Moreover, results regarding the clinical application of estrogen replacement therapy for treating sarcopenia remained inconsistent.ConclusionThe elucidation of molecular mechanisms that involve sex hormones is eagerly awaited for novel therapeutic interventions for sarcopenia.
A filtering‐based recursive extended least squares algorithm and its convergence for finite impulse response moving average systems
Authors: Zheng Jiayun , Ding Feng 
Published: March 2024

AbstractThis article considers the parameter identification problems of stochastic systems which described by the finite impulse response moving average model. Since the system is disturbed by colored noise, we introduce the data filtering technique from a view point of improving the parameter estimation accuracy. The data filtering technique is to use a filter to filter the input and output data of the system disturbed by colored noise so as to improve the identification accuracy. By using the data filtering technique, this article proposes a filtering‐based recursive extended least squares (F‐RELS) algorithm. The convergence analysis indicates that the parameter estimates can converge to their true values. Compared with the recursive extended least squares algorithm, the proposed F‐RELS algorithm can obtain more accurate parameter estimation. Finally, a numerical simulation example is given to demonstrate the effectiveness of the proposed algorithms.
Genotype × environment interaction and selection parameters for high yielding wheat genotypes under irrigated and heat stress environment
Authors: Bhandari Radhakrishna , Poudel Mukti R. 
Published: March 2024

AbstractIntroductionWheat is a significant contributor to the food and nutritional security of the world. Due to climatic constraints and heat stress condition, the potentiality of wheat to eradicate existing hunger and malnutrition has been severely limited all around the world.Materials and MethodsTo evaluate the performance and stability of elite wheat genotype under irrigated and heat stress environment, a field experiment was conducted during the wheat growing season of 2020, 2021 and 2022 under irrigated and heat stress environment that altogether created six distinct wheat growing environments.ResultsThe combined ANOVA revealed that all quantitative traits studied were significantly influenced by heat stress environments (p < 0.01). Which Won Where (WWW) model revealed, Bhairahawa lines (BL) 4407, Nepal lines (NL) 1384 and NL 1346 performed best under irrigated environments of 2020, 2021 and 2022 while BL 4407, NL 1384 and NL 1381 performed best under heat stress environment of 2020, 2021 and 2022. WWW model showed, NL 1369, NL 1386 and NL 1376 as the most stable genotypes across irrigated and heat stress environment. The phenotypic correlation, path analysis, network diagram, cluster analysis and cluster based principal component analysis analysis revealed traits, days to booting (DTB), plant height (Ph), spike length (SL), ten spike weight (TSW) and thousand kernel weight (TKW) are most closely associated with grain yield of wheat.ConclusionHigh yielding genotypes should be selected based on earliness in DTB, longer Ph, SL and higher TSW and TKW under both environments. Breeding for taller genotypes should specifically be focused to obtain high yielding genotypes under heat stress environments.
Contesting the boundaries of physics teaching: What it takes to transform physics education toward justice‐centered ends
Authors: Jones Jasmine 
Published: March 2024

AbstractThe underrepresentation of Black Americans in physics has been persistent for so long that it seems to have constrained physics educators' collective imagination when it comes to conceptualizing and pursuing equity in physics teaching and learning. Drawing on a teacher research study that foregrounds justice‐centered physics teaching, this article pushes past the “equity as access” narrative toward more expansive visions of equity and justice by reimagining physics education as a liberatory praxis. Accordingly, this study explores the complexities that emerged while expanding the boundaries of physics learning to embrace a justice‐centered curriculum through a Youth Participatory Science (YPS) project. Taught in the context of a freshman physics course at an urban public high school, this YPS project engaged students in designing solar energy systems for an African‐American community historically harmed by environmental racism. Critically evaluating curricular documents, I juxtaposed the traditional goals of physics learning with respect to definitions of community needs and assets. Simultaneously, I investigated the ways in which canonical physics knowledge dialectically interacts with interdisciplinary knowledge throughout the defining, investigating, and intervening phases of the YPS cycle. Throughout this process, I considered how physics learning provides opportunities to either reproduce or transform existing power relations within the sociopolitical and environmental schema of the community. The critical understandings constructed from this study frame what it takes to repurpose physics teaching and learning for environmental justice, specifically emphasizing the agentic pedagogical and curricular decisions teachers must negotiate to transform physics education for liberatory purposes.
The influential ambit of optimal corporate social responsibility investments on the cost of capital in Chinese private firms
Authors: Zhu Naiping , Khan Talat Mehmood , Khan Tehmina 
Published: March 2024

AbstractPrivate firms in China are contributing immensely to the country's economic growth. However, increasing the capital cost of private firms in China is a big challenge that needs to be addressed. This study intends to examine the role of optimal corporate social responsibility (CSR) investment while lowering the cost of equity capital and debt capital in Chinese private firms. In addition, this research study reveals the moderating role of state‐owned shares in the association between CSR and private firms' capital costs. By taking a sample of Chinese private firms from 2011 to 2021, this study employs the CSR optimization method. The findings show that CSR optimization tends to reduce the cost of equity capital and debt capital in Chinese private firms. Further investigation shows that over‐investment in CSR increases the cost of capital. Moreover, an increase in state‐owned shares strengthens the negative relationship between the cost of debt capital and optimal CSR investments. The present study's findings are helpful for Chinese firms to undertake optimal CSR investment.