bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensation seeking and risk adjustment: the role of reward sensitivity in dynamic risky decisions
Authors: Qianlan Yin , Shou Chen , Tianya Hou , Wei Dong , Liu Taosheng 
Published: February 2025

ObjectiveThe primary objective of our research is to delve into the relationships between sensation seeking (SS), reward sensitivity (RS), and risk adjustment (RA) within the context of dynamic risk-taking behaviors. By integrating the reinforcement learning model and neural measures obtained from dynamic risk-taking tasks, we aim to explore how these personality traits influence individual decision-making processes and engagement in risk-related activities. We aim to dissect the neural and cognitive mechanisms underlying this interplay, thereby shedding light on the stable brain-based characteristics contributing to the observed variability in risk-taking and decision-making behaviors. Understanding these links could significantly enhance our ability to predict individual differences in risk preferences and develop targeted interventions for managing risky behaviors across different contexts.MethodWe developed a task to measure RA through a structured yet uncertain environment modeled after the Balloon Analog Risk Task. We enlisted 80 young adults to perform this task, and of these, 40 were subjected to electroencephalography (EEG) to assess neural correlates of RS. Subsequently, we analyzed event-related potentials and spectral perturbations to discern neural distinctions related to RS. We compared these distinctions concerning RA among participants exhibiting different levels of SS.ResultsIndividuals exhibiting higher levels of SS (HSS) in the study displayed a tendency to disregard past risks, potentially resulting in diminished behavioral adaptability. EEG results indicated that individuals with HSS exhibited reduced neural responses to feedback compared to those with low SS, potentially affecting their feedback processing and decision-making. Moreover, the comparison of effects underscores the significant impact of RS and SS on shaping RA during dynamic decision-making scenarios.ConclusionThis study has advanced the understanding of how SS and RS influence RA, revealing that RS prompts RA, while individuals with HSS often exhibit blunted RS, leading to worse RA. Future research should focus on the specific aspects of HSS and their implications for decision-making across different risk contexts. Employing advanced neuroimaging and cognitive modeling techniques will be pivotal in unraveling the neural mechanisms driving these individual differences in risky behavior.
Diurnal variation in brain injury after cardiac arrest and cardiopulmonary resuscitation
Authors: Peng Fei , Wang Fei , Gao Bowen , Sun Ping 
Published: February 2025

BackgroundAlthough the circadian rhythm is known to influence several neurological diseases and response to treatments, its potential impact on brain injury following cardiac arrest and cardiopulmonary resuscitation (CA/CPR) remains unclear.MethodsWe performed a retrospective observational study on out-of-hospital cardiac arrest (OHCA) cases that presented to the emergency department of our hospital between September 2022 and August 2024. Based on the CA/CPR onset time, all patients were divided into two cohorts: daytime and nighttime groups. The gray-to white-matter signal intensity ratio (GWR) was analyzed using brain computed tomography (CT) images. We used the Cerebral Performance Category (CPC) to estimate the neurological outcomes. C-reactive protein (CRP), white blood cell (WBC) count, and monocyte (MONO) count levels in the plasma were also analyzed.ResultsOur study included 138 patients, of whom 68 were subjected to CA/CPR during daytime (8:00 to 20:00) and the remaining 70 were subjected to CA/CPR during nighttime (20:00 to 8:00). The imaging data showed that GWR values were significantly lower among patients subjected to CA/CPR during nighttime compared to those who were subjected to CA/CPR during daytime. Consistently, lower survival rates were observed among nighttime CA/CPR survivors. The CPC results indicated that a greater number of patients who underwent CA/CPR during daytime were rated as class 1–2 on day 3, day 5, and day 7 after achieving return of spontaneous circulation (ROSC). In contrast, a larger proportion of CA/CPR survivors in the nighttime group were rated as class 5 at the same time points. Elevated levels of C-reactive protein, white blood cell count, and monocyte count were observed in the plasma of survivors who underwent nighttime CA/CPR.ConclusionWe found that patients subjected to CA/CPR during nighttime (20:00–8:00) had worse neurological outcomes compared to those treated during daytime (8:00–20:00).
Clinical study on the treatment of acute epidural hematoma by embolization of middle meningeal artery through radial artery access combined with minimally invasive burr hole drainage
Authors: Zhang Cui , Wang Qingbo , Li Chenglong , Jing Zixuan , Zhao Xinyu , Chen Yang , Li Zefu 
Published: February 2025

ObjectivesThis study aims to evaluate the clinical effectiveness of using coil embolization via radial artery access, combined with drilling and drainage, as a minimally invasive treatment for acute epidural hematoma compared to traditional craniotomy.Materials and methodsA retrospective analysis was conducted on 134 patients with acute epidural hematoma treated at the Department of Neurosurgery, Binzhou Medical University Hospital, between January 2020 and April 2023. Among these patients, 37 underwent embolization of the middle meningeal artery through radial artery access combined with burr hole drainage, while 97 patients underwent craniotomy for hematoma removal. The 37 patients treated with embolization were designated as the experimental group, while the remaining 97 patients formed the control group. General patient characteristics, operation duration, intraoperative blood loss, postoperative complications, and Glasgow Coma Scale (GCS) scores upon admission and discharge were recorded and compared between the two groups.ResultsIn comparison to the control group, the experimental group exhibited higher rates of postoperative hematoma residuals and longer average postoperative drainage times. Nevertheless, the experimental group demonstrated several advantages including shorter operation durations, reduced intraoperative bleeding, lower rates of postoperative rebleeding and complications, as well as decreased requirements for postoperative blood transfusions and transfusion volumes.ConclusionThe surgical approach involving coil embolization via radial artery access combined with minimally invasive burr hole drainage yields favorable clinical outcomes. This technique presents as a viable treatment option for acute epidural hematoma resulting from middle meningeal artery hemorrhage.
Potential pharmacological effect of Quercetin Phytosome™ in the management of hyperuricemia: results from real-life clinical studies
Authors: Di Pierro Francesco , Rabbani Fazle , Tareen Meherullah , Nigar Roohi , Khan Amjad , Zerbinati Nicola , Tanda Maria L. , Cazzaniga Massimiliano , Bertuccioli Alexander , Falasca Paolo , Damiani Gabriele , Villanova Nicola 
Published: February 2025

BackgroundHyperuricemia is associated with several metabolic and cardiovascular disorders, and traditional treatments, such as xanthine oxidase (XO) inhibitors, often have limitations, such as severe hypersensitivity reactions or ineffectiveness in achieving target serum urate levels in some patients. Quercetin, a naturally occurring flavonoid, has shown potential as a hypouricemic agent through XO inhibition.ObjectiveThis study aims to evaluate the potential hypouricemic effect of Quercetin Phytosome™ (QP) supplementation across three cohort studies involving healthy adults with various metabolic health profiles, exploring its potential as a safe, effective intervention for hyperuricemia.MethodsClinical data collected in various clinics in Italy between September 2021 and April 2024 under real-life clinical settings from three distinct cohort studies, were analyzed. Cohort 1 consisted of 164 healthy participants (87 QP-treated, 77 probiotic Streptococcus salivarius (S. salivarius) K12-treated) who were monitored for 90 days. Cohort 2 included 22 mildly hyperuricemic adults with metabolic disorders receiving QP, while Cohort 3 comprised 64 obese adults with hypercholesterolemia, further divided into moderately hyperuricemic QP-treated group (n = 20), a moderately hyperuricemic Berberine Phytosome™ and monacolins (BM)-treated group (n = 22), and a normouricemic BM-treated group (n = 22). QP was administered at 400 mg of quercetin daily in all cohorts. Primary endpoints were reductions in serum uric acid levels, while secondary outcomes included effects on lipid profile, glycemia, liver enzymes, and treatment tolerability.ResultsIn Cohort 1, QP significantly reduced uric acid levels by 15.2% in males and 13.8% in females, with no significant changes observed in the probiotic group. Cohort 2 showed a significant 13.1% reduction in uric acid (p &lt; 0.01) and a concurrent 10.2% reduction in triglycerides (p &lt; 0.05). In Cohort 3, QP led to a 13.7% decrease in uric acid and a 20.8% reduction in triglycerides (p &lt; 0.01), with no significant uric acid changes in the BM-treated group. QP was well tolerated across all cohorts, with minimal, transient side effects.ConclusionQP supplementation demonstrates a significant hypouricemic effect. Additionally, triglyceride-lowering benefits were evident, particularly in metabolically compromised individuals (Cohorts 2 and 3), where these effects were statistically significant. With high tolerability, these findings highlight Quercetin Phytosome™'s potential as a safe adjunctive therapy for hyperuricemia management, meriting further investigation in larger, randomized trials to confirm its efficacy and safety.Clinical Trial Registrationclinicaltrials.gov, identifier NCT06652035.
Dynamic monocyte changes as prognostic indicators in operable gastric cancer: a retrospective cohort analysis
Authors: Jiang Yiwei , Sun Xianwei , Yang Chen , Song Dandan , Zhou Chongjun , Chen Xinxin , Huang Chongquan , Wang Zhonglin , Li Jiante 
Published: February 2025

ObjectiveThis study aims to elucidate the relationship between postoperative monocyte count and gastric cancer prognosis. We introduce a standardized monocyte ratio (MMR) to predict postoperative survival rates in gastric cancer patients effectively.MethodsA test cohort was created to develop and evaluate the pre- and postoperative MMR as a mortality predictor in gastric cancer patients. We used Kaplan-Meier survival analysis, complemented by univariate and multivariate analyses. The predictive utility of MMR was assessed via time-dependent ROC curves and decision-curve analysis.ResultsThe sample distributions in both cohorts were similar. The MMR showed high predictive value and significant clinical benefits in 1, 3, and 5-year overall survival (OS) assessments. These findings enhance understanding of prognosis and aid in developing more precise treatment plans.ConclusionsMMR is confirmed as an independent factor in predicting overall survival in gastric cancer patients, proving to be a reliable and cost-effective prognostic indicator.
Combination of potassium oxonate with anti-PD-1 for the treatment of colorectal cancer
Authors: Wang Yuanyuan , Hu Chenxi , Du Tianpeng , Li Jiawen , Hui Kaiyuan , Jiang Xiaodong 
Published: February 2025

IntroductionIdentification of effective therapies for colorectal cancer (CRC) remains an urgent medical need, especially for the microsatellite stable (MSS) phenotype. In our previous study, potassium oxonate (PO), a uricase inhibitor commonly used for elevating uric acid in mice, unexpectedly showed remarkable inhibition of tumor growth when combined with anti-programmed death-1 (PD-1). Further research demonstrated that the combination of potassium oxonate and anti-PD-1 could reprogram the immune microenvironment. This study aimed to explore the anti-tumor effect of PO combined with anti-PD-1, and investigate the impact on the immunosuppressive tumor microenvironment (TME).MethodsWe established a syngeneic mouse model of CRC and divided into groups of control group, single drugs group of PO and anti-PD-1, and the combination group. Use the HE staining, immunohistochemistry (IHC) and TUNEL staining of tumor issues to verify the anti-neoplasm of each group. We also tested the changes of TME through flow cytometry of spleen of mice in each group, as well as the IHC of cytokines.ResultsThe co-therapy of PO and anti-PD-1 showed admirable anti-tumor effect compared with the control group and the single drug groups. The TME were tended to an environment beneficial for killing tumors by enhancing chemotactic factor release, increasing CD8+ T cell infiltration and activation, and decreasing the amount of regulatory T cells. Moreover, IFN-γ and IL-2 secretion were found to be enriched in the tumor TME.ConclusionOur study indicated that combination of PO and anti-PD-1 could synergistically suppress CRC progression and altered the tumor microenvironment in favor of antitumor immune responses.
Cervical cancer burden and attributable risk factors across different age and regions from 1990 to 2021 and future burden prediction: results from the global burden of disease study 2021
Authors: Cheng Lu-yao , Zhao Ji-qi , Zou Ting-ting , Xu Zhong-hua , Lv Yin 
Published: February 2025

BackgroundCervical cancer (CC) is a global public health problem. We aimed to evaluate the global and regional CC burden between 1990 and 2021, identify the attributable risk factors, and project its burden up to 2035.MethodsData were extracted from the Global Burden of Disease Study 2021, and the CC incidence, mortality, age-standardized incidence rate (ASIR), age-standardized death rate (ASDR), age-standardized disability-adjusted life years (DALYs), and attributable risk factors from 1990 to 2021 were analyzed. The impacts of geographical variations, different age groups, and the socio-demographic index (SDI) on CC morbidity and mortality measurements were assessed. The attributable risk factors to CC death and DALY were evaluated, and the incidence, mortality, and DALYs to 2035 were projected.ResultsGlobally, the number of CC cases has increased from 409,548.49 cases in 1990 to 667,426.40 cases in 2021. However, the ASIR decreased from 18.11 to 15.32 per 100,000, with the greatest ASIR decrease in high SDI regions (estimated annual percentage change: -1.41). Between 1990 and 2021, the global ASDR decreased from 9.68 to 6.62 per 100,000, and the rate of age-standardized DALYs decreased from 330.11 to 226.28 per 100,000. However, these improvements were not consistent across different SDI regions. The CC incidence was the highest in the 55-59 age group, globally. The risk factors, which included unsafe sex and smoke, significantly varied by region. The global ASIR exhibited a downward trend from 2021 to 2035.ConclusionFrom 1990 to 2021, although the overall trend in incidence, mortality, and DALYs of CC exhibited a global and regional downward trend, there were significant disparities among areas with different socioeconomic development. More efficient targeted prevention and management strategies, easy access to health care in less developed regions, and risk factor modifications should be promoted, in order to reduce the global burden of CC.
The impact of precompetition state on athletic performance among track and field athletes using machine learning
Authors: Zhang Yuting , Fu Pengyu , Yu Qi , Niu Qingmei , Nie Dongfeng , Dou Xiangya , Zhang Xiaoqin 
Published: February 2025

ObjectiveThis study aims to compare the differences in the precompetition status (nutritional, physiological, biochemical, psychological, and sleep statuses) among college track and field athletes with different competition performances and to screen for key indicators of differences affecting athletic performance.MethodsMultiple indicators, traditional methods, and machine learning methods are used to detect the exercise load, fatigue index, and precompetition state of athletes with different sports performances.Results(1) Two weeks before the competition, the fat mass in the left upper limb in the BP group was significantly higher than that in the BnP group (P &lt; 0.05). The absolute values of blood basophils and triglycerides (TGs) in the BnP group were significantly higher than those in the BP group (P &lt; 0.05). The positive detection rate of urinary leukocytes in the BnP group was higher than that in the BP group, and the positive detection rate of urinary occult blood and vitamin C in the BP group was higher than that in the BnP group. (2) One week before the competition, the blood lactate dehydrogenase (LDH) in the BP group was significantly higher than that in the BnP group (P &lt; 0.05). The detection rate of positive urinary occult blood in the BnP group was higher than that in the BP group (P &lt; 0.05). (3) No significant differences were found in the daily dietary intake, energy consumption values, physical activity, sleep efficiency, real-time heart rate, real-time respiratory rate, and real-time heart rate variability between the intensive and reduced periods. (4) The Rosenberg Self-Esteem Scale score of the BnP group was significantly higher than that of the BP group (P &lt; 0.05).ConclusionPrecompetition absolute basophil, LDH, TG, white blood cells, creatine kinase, fat mass in the left upper limb, erythrocyte pressure (HCT), and individual failure anxiety can be used as training monitoring indicators that focus on tracking athlete status before the race.
Genomic, transcriptomic and metabolomic analyses of Amorphophallus albus provides insights into the evolution and resistance to southern blight pathogen
Authors: Duan Longfei , Qin Jianfeng , Zhou Gaoxin , Shen Chuan , Qin Baofu 
Published: February 2025

IntroductionAmorphophallus albus, a perennial herb in the Araceae family, is a valuable cash crop known for its high production of konjac glucomannan and high disease resistance.MethodsIn this study, we present a high-quality, chromosome-scale genome assembly of A. albus using a combination of PacBio HiFi sequencing, DNBSEQ short-read sequencing, and Hi-C technology. To elucidate the molecular mechanisms underlying southern blight resistance, we performed an integrated analysis of transcriptomic and metabolomic profiles across three infection stages of A. albus.Results and discussionHere, we assembled and annotated the complete genome of A. albus, providing a chromosome-level assembly with a total genome size of 5.94 Gb and a contig N50 of 5.61 Mb. The A. albus genome comprised 19,908 gene families, including 467 unique families.The slightly larger genome size of A. albus compared to A. konjac may have been affected by a recent whole-genome duplication event. Transcriptional and metabolic analyses revealed significant enrichment of differentially expressed genes (DEGs) and differentially accumulated metabolites (DAMs) involved in phenylpropanoid biosynthesis, plant hormone signal transduction, phenylalanine metabolism, and the biosynthesis of phenylalanine, tyrosine, and tryptophan. These findings not only advance the understanding of genetic and evolutionary characteristics of A. albus but also provide a foundation for future research on the resistance mechanisms of konjac against southern blight disease.
Network relationship between cognitive function and quality of life in community-dwelling older adults: an observational study from Beijing
Authors: Ye Yitian , Zhang Yichun , Ren Jiaju , Zhu Yanbo 
Published: February 2025

ObjectiveThis observational study aims to comprehensively explore the network relationship and mechanism of action between cognitive function and quality of life among community-dwelling older adults aged 60 and above in Beijing.MethodsThe research encompassed a cohort of 323 older adults individuals residing in the community in Beijing. Data were collected from January to July 2024 using convenience sampling. Cognitive function was evaluated using the Chinese adaptation of the Montreal Cognitive Assessment (MoCA), while quality of life was assessed through the Medical Outcomes Study 36-Item Short-Form Health Survey version 2 (SF-36v2). Cognitive assessment involved seven dimensions, namely visuospatial/executive function, naming, attention, language, abstraction, delayed recall, and orientation. Concurrently, quality of life was assessed across eight dimensions: physical functioning, role physical, bodily pain, general health, vitality, social functioning, role emotional, and mental health. Network analysis graphs were developed to investigate the interrelationships among variables, identify central nodes, and evaluate stability.ResultsIn the network, the dimensions of social functioning, role-physical, physical functioning, general health, vitality, orientation, and language showed high centrality strength. The dimensions of physical functioning, role-physical, language, and orientation exhibited strong closeness and betweenness. There were strong associations between role-physical and social functioning, physical functioning and role-physical, and vitality and mental health. The centrality stability coefficients for strength, closeness, and betweenness were 0.672, 0.672, and 0.285, respectively.ConclusionThe network structure was stable, indicating that dimensions such as social functioning, role-physical, and physical functioning play pivotal roles influencing cognitive function in community-dwelling older adults. Orientation and language were the most representative dimensions of cognitive function and may serve as important targets for interventions aimed at improving cognitive function and subsequently enhancing QoL. These findings provide practical guidance for community health interventions. Future research should explore causal relationships and develop scalable strategies to support aging populations.
Analysis of the influence factors of cultivated land transfer in Guangdong coastal important agricultural areas based on geodetectors
Authors: Fu Zhaogang , Xue Qingyi 
Published: February 2025

IntroductionsAs a key link in the development of modern agriculture, the transfer of arable land is regarded as a strategic measure to improve agricultural production efficiency and ensure national food security. Although the transfer of arable land has been widely implemented nationwide, its specific impact on agricultural production and farmers’ income varies in different regions. The analysis of regional differences in agricultural land transfer in existing literature is still insufficient.MethodsThis study is based on data from important agricultural areas along the coast of Guangdong Province in 2013, 2018, and 2023, and uses stepwise regression models and geodetectors to analyze the factors affecting spatial differentiation of agricultural land transfer.ResultCultivated land transfer in Zhanjiang, Maoming, and Yangjiang cities exhibits distinct spatial distribution characteristics, forming a gradient pattern that increases from east to west. In single-factor analysis, factors such as irrigation conditions, agricultural output value, urbanization level, electricity supply, and centralized water supply projects have a particularly prominent impact on farmland transfer. Multi-factor interaction analysis reveals that centralized water supply projects, agricultural film usage, urbanization rate, agricultural GDP, and irrigation area have a significant impact on farmland transfer.DiscussionThis study suggests that the spatial differentiation of agricultural land transfer is the result of the interaction between production characteristics, economic characteristics, population characteristics, and input characteristics. Next, it is necessary to further improve data collection, optimize research methods, and comprehensively consider more factors that may affect cultivated land transfer.