bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of soluble transferrin receptor/log ferritin index with all-cause and cause-specific mortality: National Health and Nutrition Examination Survey
Authors: Yu Yan , Lu Dongying , Zhang Zhenhui , Tao Lili 
Published: February 2024

BackgroundSoluble transferrin receptor (sTfR)/log ferritin index (sTfR Index) can be used to assess the entire spectrum of iron status, and is valuable in evaluating iron status in population studies. There is still a lack of evidence on the association between sTfR index and all-cause mortality.ObjectTo explore the association between sTfR index and all-cause mortality, as well as mortality due to cardiovascular disease (CVD) and cancer.MethodData were from the National Health and Nutrition Examination Survey (NHANES) between 2003 to 2020. Participants aged 16 years and older who had complete data of serum ferritin and sTfR were included. Pregnant individuals or those with ineligible data on death or follow-up were excluded from the analysis. Baseline sTfR index was calculated by baseline sTfR/log (ferritin) and classified as three tertile. We performed the Cox proportional hazard regression to assess the association of sTfR index (both continuous and categorical scale) with all-cause and cause-specific mortality and further assess the non-linear relationship between sTfR index and the outcomes with restricted cubic spline.ResultIn this study, 11,525 participants, a total of 231 (2.0%) all-cause deaths occurred during a median follow-up of 51 months. The risk of all-cause mortality, CVD-related mortality, and cancer-related mortality was higher in participants with highest tertile of sTfR index. After confounding factors adjustment, participants with highest tertile of sTfR index were associated with an increased risk of all-cause mortality (HR: 1.71, 95% CI: 1.14–2.57) as compared with lowest tertile. Additionally, sTfR index per SD increment was associated with a 25% increasing risk of all-cause mortality (HR: 1.25, 95% CI: 1.08–1.45, p = 0.003) and a 38% cancer-related mortality (HR: 1.38, 95% CI: 1.07–1.77, p = 0.018). These associations remained robust after adjusting for the serum ferritin as well as in various subgroups stratified by age, sex, smoking statue, hypertension, diabetes, and CVD. Spline analysis showed that there is approximately linear relationship between sTfR index with all-cause mortality (p for non-linear = 0.481). Moreover, ferritin was not a predictor of all-cause death after adjustment for confounding factors.SignificanceThis cohort study demonstrated a significant association between sTfR index increment and an increased risk of all-cause and cancer-related mortality, independent of ferritin levels.
Clinical application of machine learning‐based pathomics signature of gastric atrophy
Authors: Lan Yadi , Han Bing , Zhai Tianyu , Xu Qianqian , Li Zhiwei , Liu Mingyue , Xue Yining , Xu Hongwei 
Published: February 2024

BackgroundThe diagnosis of gastric atrophy is highly subjective, and we aimed to establish a model of gastric atrophy based on pathological features to improve diagnostic consistency.MethodsWe retrospectively collected the HE-stained pathological slides of gastric biopsies and used CellProfiler software for image segmentation and feature extraction of ten representative images for each sample. Subsequently, we employed the Least absolute shrinkage and selection operator (LASSO) to select features and different machine learning (ML) algorithms to construct the diagnostic models for gastric atrophy.ResultsWe selected 289 gastric biopsy specimens for training, testing, and external validation. We extracted 464 pathological features and screened ten features by LASSO to establish the diagnostic model for moderate-to-severe atrophy. The range of area under the curve (AUC) for various machine learning algorithms was 0.835-1.000 in the training set, 0.786-0.949 in the testing set, and 0.689-0.818 in the external validation set. LR model had the highest AUC value, with 0.900 (95% CI: 0.852-0.947) in the training set, 0.901 (95% CI: 0.807-0.996) in the testing set, and 0.818 (95% CI: 0.714-0.923) in the external validation set. The atrophy pathological score based on the LR model was associated with endoscopic atrophy grading (Z=-2.478, P=0.013) and gastric cancer (GC) (OR=5.70, 95% CI: 2.63-12.33, P&lt;0.001).ConclusionThe ML model based on pathological features could improve the diagnostic consistency of gastric atrophy, which is also associated with endoscopic atrophy grading and GC.
Global research and emerging trends in autophagy in lung cancer: a bibliometric and visualized study from 2013 to 2022
Authors: Liu Bo-Na , Chen Juan , Piao Ying 
Published: February 2024

Purpose: To highlight the knowledge structure and evolutionary trends in research on autophagy in lung cancer.Methods: Research publications on autophagy in lung cancer were retrieved from the Web of Science Core Collection database. VOSviewer and CiteSpace data analysis software were used for the bibliometric and visualization analysis of countries, institutions, authors, journals, and keywords related to this field.Results: From 2013 to 2022, research on autophagy in lung cancer developed rapidly, showing rising trends in annual publications and citations. China (1,986 papers; 48,913 citations), Shandong University (77 publications; 1,460 citations), and Wei Zhang (20 publications; 342 citations) were the most productive and influential country, institution, and author, respectively. The journal with the most publications and citations on autophagy in lung cancer was the International Journal of Molecular Sciences (93 publications; 3,948 citations). An analysis of keyword co-occurrence showed that related research topics were divided into five clusters: 1) Mechanisms influencing autophagy in lung cancer and the role of autophagy in lung cancer; 2) Effect of autophagy on the biological behavior of lung cancer; 3) Regulatory mechanisms of 2 cell death processes: autophagy and apoptosis in lung cancer cells; 4) Role of autophagy in lung cancer treatment and drug resistance; and 5) Role of autophagy-related genes in the occurrence and development of lung cancer. Cell proliferation, migration, epithelial-mesenchymal transition, and tumor microenvironment were the latest high-frequency keywords that represented promising future research directions.Conclusion: This is the first comprehensive study describing the knowledge structure and emerging frontiers of research on autophagy in lung cancer from 2013 to 2022 by means of a bibliometric analysis. The study points to promising future research directions focusing on in-depth autophagy mechanisms, clinical applications, and potential therapeutic strategies, providing a valuable reference for researchers in the field.Systematic Review Registration: [https://systematicreview.gov/], identifier [registration number].
Virtual reality hypnosis prior to radiofrequency thermocoagulation for patients with chronic pain: an exploratory clinical trial
Authors: Safy Othmane , Rousseaux Floriane , Faymonville Marie-Elisabeth , Libbrecht Dominique , Fontaine Robert , Raaf Melissa , Staquet Cécile , Tasset Hadrien , Bonhomme Vincent , Vanhaudenhuyse Audrey , Bicego Aminata 
Published: February 2024

BackgroundThe management of chronic pain may involve an array of tools, including radiofrequency thermocoagulation (Rf-Tc) of sensory nerve terminals. Like many other invasive procedures, Rf-Tc can generate anxiety in a lot of patients, either during the expectation of the procedure or in the course of it. Virtual reality hypnosis (VRH) is a promising tool for managing anxiety and pain in several situations, but its anxiolytic property has not been investigated in participants with chronic pain and going through a Rf-Tc procedure.ObjectivesThe goal of this study was to evaluate the effectiveness of VRH for reducing self-assessed anxiety in participants with chronic pain, when received in preparation for Rf-Tc.Materials and methodsThis prospective, controlled trial was conducted in the Interdisciplinary Algology Centre of the University Hospital of Liège (Belgium). Participants were assigned to two groups: VRH or control (usual care). Assessment was carried-out at 4 time points: T0 (one week before Rf-Tc); T1 (pre-intervention, on the day of Rf-Tc); T2 (immediately after the VRH intervention outside of the Rf-Tc room); and T3 (right after Rf-Tc). Medical, sociodemographic data, anxiety trait and immersive tendencies were collected at T0. Anxiety state and pain intensity were assessed at each time points. Satisfaction was examined at T3.ResultsForty-two participants were quasi-randomly assigned to the VRH or control group. No statistically significant interaction group by time was observed regarding all measured variables, including primary endpoint. However, a significant effect of time was found for anxiety and pain when considering both groups together, toward a progressive reduction.ConclusionIn the context of our study, there appears to be no significant effect of VRH at reducing anxiety in participants with chronic pain undergoing Rf-Tc. Anxiety decreases along the procedure, while pain is attenuated by the local anesthetic infiltration of the Rf site. Our results suggest that the presence of a caregiver throughout the procedure might explain the progressive decrease in anxiety. Future randomized controlled trials are needed to precisely study the effectiveness of the VRH tool, and the possibility of using it as a complementary approach for anxiety during invasive procedures.
Medical insurance, vulnerability to poverty, and wealth inequality
Authors: Zhou Xianhua , Yang Xujin 
Published: February 2024

BackgroundChina has made remarkable achievements in alleviating poverty under its current poverty standards. Despite these immense successes, the challenge of consolidating these achievements remains. In reality, health risks are among the significant factors causing rural households to fall into poverty, and medical insurance is the significant factor mitigating household vulnerability to poverty. Therefore, alleviating or guarding against households falling into poverty is essential.MethodsThis paper establishes a multi-equilibrium model that incorporates heterogeneous health risks and medical insurance. Through parameter calibration and value function iteration, numerical solutions are derived.ResultsHeterogeneous health risks significantly increase poverty vulnerability and wealth inequality in rural households. Medical insurance, through its investment incentives and loss compensation effects, efficiently mitigates these issues, especially benefiting those in poorer health. Furthermore, the dual-slanted compensation policy efficiently mitigates the adverse effects of “reverse redistribution.”ConclusionMedical insurance effectively mitigates household vulnerability to poverty and wealth inequality. Government departments must establish health records for residents. By recognizing variations in health conditions, these departments can provide households with poorer health conditions with a higher medical expense compensation ratio. In addition, the government should further focus medical expense reimbursements toward households on the cusp of escaping poverty to ensure that they are not plunged back (or further) into poverty due to medical expenses.
Factors related to depression in adults with oral health problems in Spain (2017 to 2020)
Authors: Cebrino Jesús , Portero de la Cruz Silvia 
Published: February 2024

BackgroundThe need to study the link between gender, depression, and oral health is becoming increasingly evident. This study therefore aimed to determine the prevalence and evolution over time of depression among women and men with oral health problems and to evaluate the association between depression status, lifestyle-related variables health-related variables and use of dental health services in those people.MethodsWe performed a nationwide cross-sectional study on 25,631 adults with oral health problems residing in Spain from the Spanish National Health Survey 2017 and the European Health Survey of Spain 2020, including as the main variable self-reported diagnosis of depression. We analysed independent variables such as lifestyle-related variables, health-related variables, and variables related to dental health services. Sociodemographic characteristics were considered as control variables.ResultsThe prevalence of depression among adults with oral health problems in Spain was 7.81% (10.14% for women, 5.39% for men), with a notable decrease from 2017 to 2020 in women. Depressed women had a slightly higher percentage of filled or capped teeth, and had more covers (crowns), bridges or other types of prostheses or dentures, while men had more caries. Women also made more frequent, regular dental visits for check-ups and mouth cleaning, whereas men often needed extractions. Unfavourable associated factors in both genders were: perceiving their health as good, average, poor, or very poor, and having 1–2 and ≥ 3 comorbidities. Conversely, not being a current smoker was related to less likelihood of depression. In women only, not engaging in leisure-time physical activity produced more unfavourable associated factors.ConclusionThe prevalence of depression among adults with oral health problems in Spain from 2017 to 2020 was 7.81%, but this figure has been steadily decreasing over time. In addition, the favourable and unfavourable associated factors could help us inform health professionals and authorities in order to prevent depression and enhance the care of this population according to gender.
Impact of normalized COVID-19 prevention and control measures on lower respiratory tract infection pathogenesis in hospitalized children
Authors: Feng Yuan , Zhang Huaixiao , Zhang Bo , Zhou Yinfei , Yuan Haibin 
Published: February 2024

ObjectiveThis study aimed to investigate the epidemiological characteristics of common pathogens contributing to childhood lower respiratory tract infections (LRTIs) in Xiangtan City, Hunan Province before and during the coronavirus disease 2019 (COVID-19) pandemic.MethodsA total of 11,891 enrolled patients, aged 1 month to 14 years, diagnosed with LRTIs and admitted to Xiangtan Central Hospital from January 2018 to December 2021 were retrospectively reviewed in this study. Specifically, the epidemiological characteristics of these pathogens before and during the COVID-19 pandemic were analyzed.ResultsThere was a significant decrease in the number of children hospitalized with LRTIs during the COVID-19 pandemic (2020–2021) compared to data from 2018 to 2019 (before the COVID-19 pandemic). Of these cases, 60.01% (7,136/11,891) were male and 39.99% (4,755/11,891) were female. 78.9% (9,381/11,891) cases occurred in children under 4 years of age. The average pathogen detection rate among 11,891 hospitalized LRTIs children was 62.19% (7,395/11,891), with the average pathogen detection rate of 60.33% (4,635/7,682) and 65.57% (2,670/4,209) before and during COVID-19 pandemic, respectively. The detection rates of adenovirus (ADV), bordetella pertussis (BP) and moraxella catarrhalis (M. catarrhalis) decreased dramatically, while the detection rates of influenza viruses (IFV), parainfluenza viruses (PIV), respiratory syncytial virus (RSV), haemophilus influenzae (H. influenzae), streptococcus pneumoniae (S. pneumoniae), and staphylococcus aureus (S. aureus) increased significantly during the COVID-19 pandemic. Overall, RSV, mycoplasma pneumoniae (MP), H. influenzae, and IFV were the major pathogens causing LRTIs in hospitalized children before and during the COVID-19 pandemic.ConclusionPublic health interventions for COVID-19 prevention are beneficial to reduce the incidence of LRTIs in children by limiting the prevalence of ADV, MP, BP, and M. catarrhalis, but which have limited restrictive effects on other common LRTIs-associated pathogens. Collectively, the data in this study comprehensively investigated the effects of COVID-19 pandemic on the epidemiological characteristics of respiratory pathogens, which will be beneficial for improving early preventive measures.
“FEAR PSYCHOLOGISTS” AND THE “INFERNALITY” OF AUTOCRATICAL SOCIETY: PSYCHOANALYSIS OF ONE ACCENTUATION
Authors: Soloviov O. , Litvinova O. 
Published: February 2024

This article is, due to its purpose and its context, which goes beyond psychological problems, although it is based on it, written rather in the style of an essay. This made it possible to describe the phenomenon of “psychologists of fear” and to point out its psycho-social nature, although not with the necessary scrupulousness. The phenomenon of the “psychologist of fear” is considered against the background of modern sociality, which allows us to consider the close, if not to say, inextricable, functional (causal) connection between, on the one hand, the inner-psychic world of a dictator who gains power through a distorted electoral procedure, and, on the other hand, by the subconscious, archetypal, biologically engaged psyche of the “man of the masses”.
It is shown that this interpersonal, functional inseparability of the “grand I” of the dictator and the “collective WE” of the human mass is based, including, and not least, on the archetypes of evil, which in the modern “infernal culture” can be openly imposed, philosophical legitimized in totalitarian societies. The mental “toolkit” is listed, thanks to which the psycho-social phenomenon of evil functions within individual psyches and is integrated into the social phenomenon. It is pointed out the ontological foundations of the phenomenon of evil, which is based on the fundamental ability of a person to subjectively evaluate anything (Soloviov, 2015) and, guided by this evaluation, through his motor (muscular) acts, translate the contents of the individual psyche into the information content of sociality.
INTERPRETATIVE PHENOMENOLOGICAL ANALYSIS AS A METHOD OF QUALITATIVE PSYCHOLOGICAL RESEARCH
Authors: Bayer O. 
Published: February 2024

The aim of the interpretative phenomenological analysis is revealed, in particular, the investigation of one’s personal life experience from the perspective of the narrator as well as the impact of its parts ‒ phenomenology, hermeneutics, and ideography ‒ on its procedure and contents. Experience as one’s internal world, the unity of its aspects (desires, feelings, motivation, assumptions, etc.) that are meaningful for them based on which they construct their actions are defined as an object of the research in IPA. Experience is considered as a phenomenal, but not objective reality; the importance of investigating one’s experience within their specific social and cultural context is stressed. The narrator acts as an experiential expert. The subjectivity bias of the researcher is inevitable; the author offers to focus on the way the latter shapes research as well as consider it when processing empirical data both as the system of values of the respondent and the researcher. IPA foresees “disciplined spontaneity” of the researcher that includes following both the structure and the demand of a free scientific inquiry. The synthesis of meaning-making of research participants and the researcher is postulated.
IPA poses a question of relationship between the processes of cognition, the contents of narratives, and one’s behavior. Contemplating on a meaningful event is understood as a part of the being-in-the-world but not as a mere cognitive activity. IPA methodologists see people as those who existentially reveal the world. When speaking on life events that make sense to a person, they simultaneously realize a big number of tasks but not only picks up words-carriers of meaning available in the culture. The stress is done also on the aspects of life world experiencing: temporality, spaciality, embodiment, self, sociality, discourse, and project.
Interviews is named the basic method for getting empirical evidence (repeated interviews are allowed), but multi-mоdal forms of data collection are also acceptable. The researcher carries out profound, thorough analysis of a case (n=1...30), on the basis of which constructs a way to universal laws and structures. As a result, the research conducted on the grounds of IPA, often investigate existential issues and contain descriptions of transformational experience bringing change, touching upon one’s identity and feelings of the self.
Efeitos da experiência com a leitura no processamento de frases na voz passiva por adultos: um estudo exploratório de priming estrutural
Authors: Pires Brenda Talissa , Mota Mailce 
Published: February 2024

O presente estudo investigou o processamento de frases na voz passiva por adultos falantes nativos do português brasileiro (PB) com baixa experiência com a leitura durante a infância. A partir do paradigma do priming estrutural, o estudo investigou (1) se falantes com baixa experiência em leitura na infância são suscetíveis aos efeitos de priming estrutural durante a compreensão de sentenças passivas e ativas, (2)se há diferença na magnitude desses efeitos entre os falantes do PB com baixa experiência na leitura (grupo experimental, N=8) e aqueles com maior escolaridade e contato com a leitura durante a infância (grupo controle, N=8) e (3) se os efeitos de priming sintático na compreensão são dependentes da repetição verbal entre prime e alvo. Realizou-se um experimento comportamental de priming estrutural com 16 participantes (13 mulheres; média de idade = 46,6), em que sentenças ativas e passivas foram manipuladas em uma tarefa de seleção de imagens. A verificação de efeitos de priming foi feita a partir da acurácia na compreensão de sentenças passivas. Os resultados apontaram efeito de priming estrutural para os dois grupos apenas quando houve repetição estrutural e verbal entre prime e alvo. Entretanto, não foi verificada uma diferença significativa na magnitude do efeito de priming estrutural entre os grupos. Em conjunto, os resultados indicam que os efeitos facilitadores de priming estrutural na compreensão de sentenças na voz passiva em PB estão atrelados ao impulso lexical e não são mediados pelo grau de experiência com a escrita na infância.
7131 Çeliğinin Hassas Dökümünden Elde Edilen Döküm Atık Kumu Katılarak Şamot Refrakter Üretimi
Authors: BAHTLI Tuba , BOSTANCI Veysel Murat 
Published: February 2024

Alüminasilikat esaslı kalıplar hassas döküm proseslerinde kullanıldıktan sonra atık haline gelerek, geri dönüşüm yapılmadan birikmesi çevreye zarar vermekte ve sorun haline gelmektedir. Bu çalışmada, 7131 çeliğinin hassas dökümünden sonra oluşan hassas döküm atık kumu (PCWS-A) kullanılarak şamot refrakter malzemeler üretilmiştir. Üretilen şamot refrakter malzemelerin fiziksel, mekanik ve termal şok özellikleri belirlenmiş, malzemelerinin XRD (X-ışını kırınım yöntemi) ve SEM (taramalı elektron mikroskobu) analizleri yapılmıştır.
Elde edilen sonuçlara göre termal şok testi öncesi ve sonrası PCWS-A kullanılarak üretilen şamot refrakter malzemelerin mekanik ve termal özelliklerinin iyileştirildiği ve dolayısıyla hassas döküm atık kumları ile şamot refrakter tuğla üretiminin performans, maliyet ve çevre açısından avantajlar sağlayacağı öngörülmüştür. Sağlanacak bu avantajlarda, kullanılan PCWS-A içerisinde refrakter malzemelerin mekanik özelliklerine katkı sağladığı bilinen zirkonun bulunmasının etkili olduğu düşünülmektedir.