bluuebunny/crossref_metadata_2025_split huggingface dataset:
RNA-seq-based elucidation of lactylation in breast cancer
Authors: He Puxing , Du Huan , Zhou Qing , Wu Yaolu 
Published: April 2024

IntroductionLactylation is the covalent modification of histones using lactate as a small molecule precursor, playing a role in epigenetic regulation. As a novel protein post-translational modification, it has demonstrated significant relevance in the field of cancer diagnosis and therapy. However, the interaction between lactylation and tumor cells in breast cancer has not been extensively investigated.Material and methodsWe acquired breast cancer-related data from the GEO and TCGA databases. Lactylation-related genes were identified from the differentially expressed genes. We utilized COX and LASSO regression to identify genes with significant prognostic value for constructing a prognostic model and assessing its predictive performance. This model was integrated with clinical parameters to create a nomogram. Finally, we conducted immune infiltration analysis, analyzed differences in biological functions, and assessed drug sensitivity.ResultsWe ultimately identified 3 lactylation-related genes significantly associated with prognosis. These genes were used to construct a prognostic model and calculate a risk score. Using the median score, patients were divided into high-risk and low-risk groups. Notably, the low-risk group patients exhibited better prognosis and higher levels of immune infiltration. GO/KEGG enrichment analysis revealed that PGK1, the gene with the highest HR among these genes, is widely involved in immune, metabolic, and proliferative signaling pathways. Its high expression also correlates with increased sensitivity to anti-tumor drugs.ConclusionsWe showcased the potential of lactylation-based molecular clustering and prognostic profiling for predicting survival, immune status, and treatment response in breast cancer patients. Additionally, we envision the utilization of PGK1 as a diagnostic marker and therapeutic target in the cancer.
PUBLIC SECTOR FINANCIAL MANAGEMENT REFORMS AND GOVERNMENT EXPENDITURE IN NIGERIA
Authors: Dr Eunice Ralph Court  , Dr Marshal Iwedi  
Published: April 2024

In Nigeria, governmental inefficiencies and mismanagement of public resources have led to challenges in fulfilling societal needs effectively. To address these issues, various financial management reforms have been implemented, aiming to enhance transparency, accountability, and efficiency. However, the impact of these reforms on government expenditure remains uncertain due to persistent corruption and operational challenges. This study investigates the influence of public sector financial management reforms, including the Government Integrated Financial Management Information System (GIFMIS) and the Integrated Personnel and Payroll Information System (IPPIS), on government expenditure in Nigeria. A conceptual framework is proposed to understand the relationship between these reforms and expenditure. Theoretical and empirical reviews provide insights into the context and previous findings related to financial management reforms. The methodology involves survey research and secondary data analysis, focusing on 16 years of data from federal ministries. Descriptive statistics and regression analysis are used to analyze the data. Results suggest mixed findings regarding the impact of GIFMIS and IPPIS on government expenditure, with some indications of potential effects but inconclusive statistical significance. Discussion of findings highlights the complexity of reform implementation and the need for further research to inform policy decisions effectively. Recommendations include conducting comprehensive studies, enhancing monitoring mechanisms, capacity building, addressing implementation challenges, promoting transparency, sustaining political will, sharing best practices, and engaging stakeholders.
Keywords: Public Sector Financial Management Reforms, Government Expenditure, GIFMIS, IPPIS, Nigeria, Governance.
ESTUDO DE CASO: OS DESAFIOS ENFRENTADOS NA GESTÃO ESCOLAR DE ENSINO MÉDIO DE TEMPO INTEGRAL PROFESSORA MARIA MARGARIDA DE CASTRO ALMEIDA, FORTALEZA, CEARÁ, BRASIL
Authors: Rebouças Amsterdan Ferreira , Rebouças Glacimeyre Lima 
Published: April 2024

A presente pesquisa consiste em um Estudo de Caso sobre os desafios enfrentados na gestão escolar do Ensino Médio de tempo integral da escola Professora Maria Margarida de Castro Almeida, localizada na cidade de Fortaleza, Ceará, Brasil. Para isso foi tecida uma robusta discussão sobre o contexto da gestão democrática no ensino público, com suas concepções e processos de transformação, organizando-se para dar resposta eficaz e rápida aos desafios que enfrenta, principalmente àqueles que refletem competências do gestor diante uma escola democrática e articulada através de políticas públicas. Nesse sentido, entende-se que a gestão democrática com a participação de todos pela construção coletiva é a ideal. Durante o desenvolvimento do presente trabalho foram feitas análises exploratórias por meio de artigos, livros, documentos e entrevista semiestruturada aplicada a uma amostra da comunidade educadora da referida escola. Demo (2013); Dourado ( 2012); Freire (2015); Libâneo, (2017); Lück (2015); Lakatos e Marconi (2017); Minayo (2017); Oliveira (2018); Paro ( 2016); outros, foram base teórica, juntamente com as fontes documentais que incluem observações, dados, programas, relatórios, regimentos, leis do ensino, orientações e Projeto Político Pedagógico da escola objeto de estudo. A abordagem da presente pesquisa foi de natureza qualitativa. Como trabalho metodológico foi realizada uma entrevista por meio da ferramenta questionário, com o intuito de melhor caracterizar as práticas de gerenciamento e as competências trabalhadas pela gestão escolar da referida escola à luz de uma gestão idealmente democrática. Os resultados das análises apontaram para a necessidade de uma reflexão coletiva sobre os desafios da gestão nessa escola de tempo integral de ensino médio sob os vieses das ações democráticas pautadas em seu projeto político-pedagógico. Constatou-se também, que, na gestão escolar da referida escola há o uso de um modelo padrão de gestão, baseado no compromisso com a integralidade da ação educativa e que está passando por processos de mudança e desafios das concepções e procedimentos de uma gestão democrática participativa. Os resultados da entrevista relevaram a necessidade de serem estabelecidos intensos debates nos espaços escolares sobre a educação integral e as práticas de uma gestão democrática, visando o engajamento por parte de todos nesse processo educativo.
RELATÓRIO DE ESTÁGIO DE TRIAGEM PSICOLÓGICA: IMPORTÂNCIA PARA O APRENDIZADO CLÍNICO DE ESTUDANTES DE PSICOLOGIA
Authors: Tissen Monica Rogalsky , Silva Diego da 
Published: April 2024

Neste trabalho foi realizado um relatório, de como foram feitas as triagens para o encaminhamento da futura terapia dos pacientes na UniEnsino de Curitiba-PR. Com isso podendo colocar que o braço foi o curso de psicologia que visou junto com sua coordenação e diretoria essa oportunidade de atuar junto as comunidades e escolas da região. Faremos uma descrição histórica desse trabalho com as reações dos candidatos. Demonstrar como foi aplicado a experiência das triagens realizadas presencialmente e online, as quais foram muito utilizadas no período da pandemia. Com esse trabalho de triagem a nossa instituição pode ser um braço dentro da comunidade, buscando colocar esse trabalho de uma forma muito acessível e tendo a perspectiva de resultados satisfatórios. Veremos como foi importante essa triagem a ser realizada com a população e como foi o primeiro encontro com essa nova oportunidade de receber auxilio nos seus momentos de dificuldades.
Abstracts From the First Annual Research Day Hosted by the Michigan State University College of Osteopathic Medicine, Novi, Michigan, May 15, 2023.
Authors: Amalfitano Andrea , Obando Patricia , Ismail Rana , Akenami Francis 
Published: April 2024

The Spartan Medical Research Journal (SMRJ) is pleased to publish abstracts from the First Annual Research Day hosted by the Michigan State University College of Osteopathic Medicine (MSUCOM), held in Novi, Michigan, on May 15, 2023. Sponsored by MSUCOM, the Statewide Campus System (SCS), and Research, Innovation, and Scholarly Engagement (RISE), this event showcased a total of 139 selected research abstracts following a meticulous blinded review by the MSUCOM Research Day Planning Committee and SMRJ editorial staff. These abstracts were subsequently presented at the MSUCOM First Annual Research Day in 2023, with awards for exceptional oral and poster presentations conferred on May 15, 2023. Of the 139 presentations that were ultimately chosen, 45 authors consented and elected to have their abstracts published in SMRJ. The abstracts from 2023 encompass a wide array of contemporary medical and clinical subjects, incorporating a variety of research designs that cover basic science, clinical research, case reports, medical education, and quality improvement. While abstracts offer concise overview of research projects or presentations, they do not permit a comprehensive evaluation of the scientific rigor employed in the respective works. Although these abstracts offer preliminary results that may necessitate further refinement and validation, they serve a vital function in disseminating novel research concepts and advancements in the discipline of medicine. This knowledge-sharing promotes meaningful dialogue among researchers, clinicians, and educators, thereby making a valuable contribution to the collective body of knowledge in the fields of medical sciences and osteopathic medicine. Andrea Amalfitano, DO, PhD Osteopathic Heritage Foundation Professor of Pediatrics, Microbiology and Molecular Genetics Professor, BioMolecular Science Gateway Editor-in-Chief, Spartan Medical Research Journal (SMRJ) MSU College of Osteopathic Medicine- Statewide Campus System C. Patricia Obando S., PhD Associate Dean and DIO, Graduate Medical Education Associate Professor- MSU College of Osteopathic Medicine- Statewide Campus System Rana Ismail, PhD, MSc, CPHQ Director of Research Editor, Spartan Medical Research Journal (SMRJ) MSU College of Osteopathic Medicine- Statewide Campus System Francis Akenami, BMLS, PhD, MSc, FIMLS Managing Editor Spartan Medical Research Journal (SMRJ) MSU College of Osteopathic Medicine- Statewide Campus System
Sobreuso de ecografía transvaginal en un hospital universitario privado de Argentina: estudio de corte transversal
Authors: Iñurrategui Maria Celia , Rodriguez Tablado Manuel , Esteban Santiago , Kopitowski Karin , Marchitelli Claudia , Terrasa Sergio Adrian 
Published: April 2024

Introducción. Si bien contamos con recomendaciones basadas en la evidencia en contra de realizar tamizaje de cáncer ovárico con ecografía transvaginal debido a que aumenta el riesgo de resultados falsamente positivos y de cascadas diagnósticas, sin disminuir la mortalidad por esta enfermedad, su solicitud en mujeres sanas es frecuente. Sin embargo, no conocemos la magnitud de la implementación de esta práctica, que constituye un cuidado de bajo valor.
Objetivo. Documentar el sobreuso de ecografías transvaginales realizadas en forma ambulatoria en un hospital universitario privado de Argentina.

Métodos. Estudio de corte transversal de una muestra aleatoria de ecografías realizadas en forma ambulatoria durante 2017 y 2018. Mediante revisión manual de las historias clínicas, la solicitud de cada ecografía fue clasificada como apropiada cuando algún problema clínico justificaba su realización, o inapropiada cuando había sido realizada con fines de control de salud o por una condición clínica sin indicación de seguimiento ecográfico.

Resultados. De un total de 1.997 ecografías analizadas, realizadas a 1.954 mujeres adultas (edad promedio 50 años), 1.345 (67,4%; intervalo de confianza [IC] 95% 65,2 a 69,4) habían sido solicitadas en el contexto de un control de salud o sin un problema asociado en la historia clínica y otras 54 (8,3%; IC 95% 6,3 a 10,7), por condiciones de salud para las que no hay recomendaciones de realizar seguimiento ecográfico.

Conclusiones. Esta investigación documentó una alta proporción de sobreutilizacion de la ecografías transvaginales en nuestra institución. Futuras investigaciones permitirán comprender los motivos que impulsan esta práctica y ayudarán a diseñar intervenciones para disminuir estos cuidados de bajo valor.
The proximate composition and phytochemical screening of Momordica Balsamina (balsam apple) fruit and leaves
Authors: JAICHAND Viruska , MELLEM John Jason , MOHANLALL Viresh 
Published: April 2024

Malnutrition is a global issue that affects both children and adults irrespective of their socio-economic status. It is therefore important to find various means to tackle malnutrition. This is especially important as undernutrition and overnutrition can be linked to a variety of non-communicable diseases (NCDs). Therefore, this study aimed to gather more insight into the nutritional and phytochemical quality of Momordica balsamina leaves and fruit (fruit pericarp, fruit flesh and seeds). The results showed that M. balsamina had a nutritional composition that would be advantageous to the human diet. The nutritional quality was verified by the presence of a high protein percentage across all samples (19.72–29.08%), with the leaves containing the highest protein content (29.08% ± 0.77). There was also a low-fat content present across all samples which ranged from 1.03% to 2.40%. The ash content indicated the presence of total minerals to be adequate (2.93–21.16%), where the pericarp had the highest ash quantity (21.16% ± 0.09). Overall, the moisture levels were low (7.11–13.40%); with M. balsamina seeds containing the highest carbohydrate content (67.84% ± 0.30).
Moreover, rich in the major phytoconstituents, M. balsamina extracts were found to contain alkaloids, saponins, cardiac glycosides, steroids and triterpenoids. Based on these findings, it can be deduced that the incorporation of M. balsamina into an individual’s diet could prevent diseases associated with malnutrition and could be used to supplement the human diet in managing certain NCDs.
Rezension von: Wohlfeil, Rainer (Hrsg.), Der Bauernkrieg 1524-26 ...
Authors: Wunder Gerd , Wohlfeil Rainer 
Published: April 2024

Rainer Wohlfeil (Hrsg): Der Bauernkrieg 1524-26. Bauernkrieg und Reformation (Nymphenburger Texte 21) München 1975, 291 S. DM 28,-
Hans-Ulrich Wehler (Hrsg): Der deutsche Bauernkrieg 1524-26. (Geschichte und Gesellschaft Sonderheft 1) Göttingen 1975, 356 S.Bernd Moeller (Hrsg): Bauernkriegs-Studien. (Schriften des Vereins für Reformationsgeschichte 189.) Gütersloh 1975, 106 S., DM 24,-Peter Blickle (Hrsg): Revolte und Revolution in Europa. Referate und Protokolle des Internationalen Symposiums Memmingen. (Historische Zeitschrift Beiheft 4). München 1975, 332 S.
ORGANIZING EFFECTIVE INTERACTION BETWEEN MANAGING COMPANIES AND HOMEOWNERS THROUGH A SYSTEM FOR CONTROL AND EVALUATION OF SERVICE QUALITY
Authors: КОРОХОВА И.В. 
Published: April 2024

В cтатьe представлены результаты исследования вопроса эффективного взаимодействия между управляющей организацией и собственниками помещений. В ходе работы выявлено, что установление и поддержание взаимопонимания сторон является основополагающим фактором в деятельности организаций жилищно-коммунального хозяйства при оказании услуг по санитарному и техническому обслуживанию общего имущества. Кроме того, был проведен анализ эффективности деятельности управляющей организации с применением клиентоориентированного подхода. В качестве решения вопроса по организации эффективного взаимодействия управляющей организации и собственников помещений, авторами предложена система контроля соотношения качества и стоимости услуг по поддержанию надлежащего состояния общего имущества посредством учета мнения собственников помещений В процессе исследования рассмотрена и выполнена оценка деятельности организаций в жилищно-коммунального хозяйства, по результатам которой в дальнейших исследованиях будет сформирован рейтинг управляющих организаций.
This paper presents the results of the research on how to establish efficient communication between management companies and homeowners. The author found that setting and supporting the interaction between the parties is a fundamental factor for housing and utilities infrastructure. The analysis of the efficiency of the management company was executed using a customer-centric approach. As a solution, the author proposes to implement a system of control of quality and cost of services provided to maintain the common property. This takes into consideration the opinions of the homeowners. The study includes the assessment of the services provided as part of housing and utilities management, which will be later used to create a rated list of managing companies.
The Archaeology of Hellenism: Olympia and the Presence of the Past
Authors: Miller Peter J. 
Published: April 2024

Abstract
Olympia holds a central place in conceptions of modern sport, Hellenism, and the Olympic Games. This article traces the concurrent development of the site and Panhellenism and Hellenism through its landscape, built environment, and its reception over the past 3,000 years. By tying together Pierre de Coubertin's Olympism to the physical landscape of ancient Olympia, this article argues that the site itself has contributed, through multiple permutations and through several key changes in the early Iron Age, Roman period, and nineteenth century to the global Hellenism that is at the foundation of the modern Olympic Games.
Objects, Olympics, and Femininity: Exploring the Impact of a 1924 Handheld Fan on Gender at the Games
Authors: Brice Julie 
Published: April 2024

Abstract
On the second level of the Olympic Museum in Switzerland lives a handheld fan from the 1924 Paris Olympics featuring five sportswomen. The museum describes the fan as a souvenir from the Games and an advertisement for a French perfume company. However, this fan is much more than an advertisement or souvenir. Drawing upon new materialist theory, which envisions objects as lively, this article looks toward the ways the fan was productive in developing ideas around gender at the Olympics. Using an object biography, this research explores how the fan contributed to the New Woman femininity of the 1920s and currently produces a narrative of the International Olympic Committee as being a gender progressive organization. In so doing, it explores how an object that is often overlooked by many at the museum plays a powerful role in understandings of gender across the history of the Games.
Rhodesian Readmission and the Decolonization of the National Olympic Committee of Zimbabwe
Authors: Ivey James Alexander 
Published: April 2024

Abstract
In May 1980, the International Olympic Committee (IOC) recognized the National Olympic Committee of Zimbabwe (ZOC) after the latter had spent five years in exile under its former name, the National Olympic Committee of Rhodesia (ROC). Robert Mugabe's Zimbabwean government's desire to have a team compete at the 1980 Moscow Olympics delayed the multiracial restructuring of the ZOC. The government's efforts to reform the ZOC, replacing the old white ROC members, transformed into a two-year-long contentious struggle. After an intervention by the IOC in June 1982, a compromise was reached. The composition of the new ZOC represented the government's greater control over sport in the country. The reformation of the ZOC demonstrates the complex process of transition from Rhodesia to Zimbabwe and the difficulties of decolonization in sport. In examining these events, this article bridges the gap between colonial Rhodesian and postcolonial Zimbabwean sport and presents a case study of decolonization within a sports administration.
THE MAIN PROBLEMS OF INDUSTRIAL ENTERPRISES IN THE CONTEXT OF DIGITALIZATION
Authors: Веселов Д.И. 
Published: April 2024

Целью настоящей статьи является выявление ключевых проблем промышленных предприятий в период экономических трансформаций, а также предложение путей их решения. В процессе достижения цели исследования автором показано, что современные российские промышленные предприятия сталкиваются с проблемой дефицита персонала, в частности, нехватки руководящего персонала, а также линейного на должности менеджеров по продажам, занимающихся сбытовой деятельностью. Среди проблем также выявлены трансформации в сложившихся цепях поставок, повышение стоимости импорта и трудности с привлечением финансирования. Сделан вывод, что применение инструментов стратегического менеджмента является одним из эффективных способов сохранения конкурентоспособности промышленных предприятий в текущих экономических условиях. Промышленные предприятия должны быстро адаптироваться к изменяющимся условиям и уделить особое внимание кадровой политике, в особенности мотивации и организации трудовой деятельности с целью привлечения компетентных специалистов в отрасль. Также целесообразно применять маркетинговые инструменты для организации системы сбыта продукции с целью увеличения доли рынка и обеспечения получения финансового результата. Предложен метод решения проблем, связанный с привлечением необходимого финансирования. Промышленным предприятиям целесообразно применять инструменты бюджетирования и создавать резервы для покрытия непредвиденных расходов в кризисных ситуациях.
The purpose of this article is to identify the key problems of industrial enterprises during the period of economic transformations, as well as to propose ways to solve them. In the process of achieving the research goal, the author shows that modern Russian industrial enterprises are faced with the problem of staff shortages, in particular, a shortage of senior staff, as well as linear positions of sales managers engaged in sales activities. Transformations in the established supply chains, increasing import costs and difficulties in attracting financing were also identified among the problems. It is concluded that the use of strategic management tools is one of the effective ways to maintain the competitiveness of industrial enterprises in the current economic conditions. Industrial enterprises must quickly adapt to changing conditions and pay special attention to personnel policy, especially motivation and organization of work activities in order to attract competent specialists to the industry. It is also advisable to use marketing tools to organize a product sales system in order to increase market share and ensure financial results. A method of solving problems related to attracting the necessary financing is proposed. It is advisable for industrial enterprises to use budgeting tools and create reserves to cover unforeseen expenses in crisis situations.