bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative liraglutide modulates control of fat and glucose metabolism during cardiopulmonary bypass surgery
Authors: van Wilpe Robert , Hulst Abraham H , Thiessen Steven E , DeVries J Hans , Preckel Benedikt , Hermanides Jeroen 
Published: February 2025

Introduction
Glucagon-like peptide-1 receptor agonists reduce insulin requirements and improve glucose control when administered before cardiac surgery. An increase in endogenous insulin release is the most likely mechanism, but this has never been studied in the setting of cardiac surgery. We hypothesized that liraglutide increases pancreatic insulin secretion during cardiac surgery with cardiopulmonary bypass (CPB).

Methods
We performed a planned prospective substudy of a multicenter randomized-controlled trial (GLOBE trial, NTR6323). Patients undergoing cardiac surgery with CPB were randomized to receive either two preoperative subcutaneous injections of liraglutide or a matching placebo. We measured hormone concentrations before and after surgery, including insulin, glucagon, C-peptide and free fatty acid (FFA), and calculated HOMA-B, HOMA-IR and insulin/glucagon ratios. We compared between-group and before and after surgery differences in outcomes.

Results
Metabolic hormone concentrations were measured in 37 participants. HOMA-B revealed that liraglutide increased insulin secretion relative to glycemia (258 ± 179 vs 116 ± 180, difference (95% CI): 142 (24–261), P = 0.004). While insulin, C-peptide and glucagon levels did not differ significantly between groups, the insulin/glucagon ratios were significantly higher in the liraglutide group (preoperatively: 1.09 ± 0.45 vs 0.79 ± 0.35 difference (95% CI): −0.30 (−0.57 to −0.03), P = 0.039). Overall, postoperative insulin levels decreased >60% from preoperative insulin levels (55 ± 31 to 21 ± 9.8, difference (95% CI): −29 (−36 to −22), P < 0.001).

Conclusion
Preoperative liraglutide administration increased beta-cell function, measured as HOMA-B, and higher insulin/glucagon ratios. These results could explain the lower glucose and FFA concentrations in the liraglutide-treated patients. Interestingly, in both groups, we observed a remarkable drop in insulin and other hormone levels over the course of surgery.
Barriers experienced by Stroke survivors when participating in meaningful occupations in the community
Authors: Mohotlhoane Refilwe , Nemakanga Mashudu Norman 
Published: February 2025

Introduction: There are various personal and environmental factors that hinder the stroke survivors’ participation in meaningful occupations within a rural and semi-rural community context. Thus, occupational therapists need to consider such barriers in order to provide holistic treatment.
Aim: This study intended to explore the barriers experienced by stroke survivors on their participation in meaningful occupations in a rural and semi-rural community.
Method: An explorative qualitative study was conducted, using a purposive sampling method to recruit participants at a public healthcare district hospital. Data were collected at the participants’ homes using individual semi-structured interviews. The researcher made use of open-ended questions guided by the Occupational Therapy Practice Framework 3rd edition and the Person Environment Occupation Performance model.
Findings: Four themes related to the barriers experienced by stroke survivors on their participation in meaningful occupations emerged: (i) physical barriers, (i) psychological barriers, (iii) financial and (iv) environmental barriers.
Conclusion: The barriers explored in this study compelled the stroke survivors to accept varying degrees of assistance from their caregivers. The findings of this study could assist occupational therapists to consider the factors that hinder the stroke survivors’ participation in meaningful occupations in rural and semi-rural South African communities, and inform treatment aims that are relevant to the respective communities. If occupational therapists consider these barriers when planning treatment, this could assist with maximizing in- dependence in all areas of stroke survivors’ lives, lessening the burden of care on their caregivers and decreasing the patient load on clinical and community occupational therapists.
Implications for practice
Stroke survivors dwelling in the semi-rural and rural community contexts experience barriers which are unique to such settings. Thus, occupational therapist should be aware of the differences of barriers experienced not only in the hospital setting, but in the community context that stroke survivors are reintegrated to. Such consideration could contribute to intervention focussed on the individual’s specific needs with regard to participation in meaningful occupations within the semi-rural and rural contexts they reside in.
Determinants Factor of The Use Of E-Wallets for Students and According to The Islamic Perspective
Authors: Zurly Deby Alicia , Wiranatakusuma Dimas Bagus , Paputungan Alvaizy Dwi Putra 
Published: February 2025

One of the best inventions of the 21st century is the electronic wallet (e-wallet) which is an integral part of the electronic payment system. As of today, almost all citizens in Indonesia use e-wallets as a payment method. E-wallet is an application or feature developed to make it easier for users to make payments. The use of e-wallets can be accessed easily via the internet, can have a positive impact and also have a negative impact on the use of electronic money services.The study involved students consisting of a man, as well as a woman with ages varying from 19 to 24 years old. Using a qualitative approach, this study uses in-depth interviews as a data collection technique and also obtains from relevant websites or journals. This research shows that E-wallets have grown very rapidly and are used by various groups, including students as millennials. E-wallets are not only understood as a place to store money electronically, but also as a digital payment system with various features, such as top ups, bill payments, bank card storage, money transfers and withdrawals, etc. Students use e-wallets for various purposes, such as paying for online transportation, buying food/drinks, paying bills, etc. There are several fundamental reasons students use e-wallets as a payment method because of the promos offered, ease of transactions, and ease of operation. In using e-wallets, students not only feel comfortable in shopping, but also the convenience of paying because it can be done anywhere as long as the user is connected to the internet. Various conveniences offered by e-wallets, one of which is the simple appearance of the application that allows many users to understand how to operate it quickly.
Oral Health-Related Quality of Life (OHRQoL) in Menopausal Medically Compromised Patients at RSGM UMY
Authors: Allifiah Bella Pardian Nur , Triswari Dyah , Hartanti Hartanti 
Published: February 2025

Menopause is the time of life when a woman’s ovaries stop producing hormones and the menstrual periods stop. Menopausal women experience a decrease in the function of estrogen and progesterone hormones as a sign of the stopped fertile period for women. Menopause causes hormonal change and systemic conditions for menopausal woman. The systemic condition from hormonal change often makes medically compromised in menopausal woman. These conditions can be related to quality of life-related dental and oral health. This study aims to describe Oral Health-Related Quality of Life (OHRQoL) in menopausal patients with medically compromised at RSGM UMY. This type of research used is descriptive observational with cross-sectional design. 110 participants menopausal women with medically compromised 45 years were given were given the OHIP-14 questionnaire using interview techniques. This study used Oral Health Impact Profile-14 (OHIP-14) questionnaire instruments with frequency data distribution analysis. 40 respondents (36.6%) have good quality of life, 66 respondents (60%) have moderate quality of life, and as many as 4 respondents (3.6%) have poor quality of life. The respondents mayority felt complaints on the physical disturbance dimension of discomfort when chewing. Based on OHIP-14 questionnaire showed that most of the respondents have moderate quality of life (60%).
A manifestação da sombra em o Gato Preto, de Edgar Allan Poe: um estudo junguiano
Authors: Murça Amanda , Alves Biserra Wiliam 
Published: February 2025

Resumo: O gato preto não é um símbolo usado primacialmente por Edgar Allan Poe, nem foi ele o último a utilizá-lo em seus recursos narrativos. Dessa forma, entende-se que o gato preto, por ter significados semelhantes em diferentes narrativas ao longo da história, constitui um símbolo representante de um arquétipo, que, para Carl Gustav Jung, é um conteúdo inconsciente presente em toda a humanidade e, por isso, esse inconsciente se chama inconsciente coletivo. Ao explorar esses conteúdos do inconsciente, encontra-se a Sombra, arquétipo que melhor representa o que a humanidade entende como mal. Sendo assim, ao analisar o discurso do narrador de O gato preto, observa-se que o comportamento do animal é reflexo ou condutor das ações malignas do indivíduo que, embora tente ignorar ou extinguir o gato, depara-se com ele até o fim da narrativa. Nesse sentido, este artigo procura dar embasamento teórico para a hipótese de que o gato preto, pertencente à narrativa supracitada, simboliza a sombra do narrador-personagem de O gato preto, de Edgar Allan Poe.

Palavras-chave: Gato preto; Sombra; Inconsciente coletivo; Arquétipos.
Design, analysis, and implementation of a high-gain quasi-switched boost inverter for renewable energy applications
Authors: Hosseinpour Majid , Azimi Pooria 
Published: February 2025

The increasing demand for efficient renewable energy conversion highlights the importance of advanced inverter technologies, particularly those capable of boosting DC voltage while converting it to AC. Conventional inverters face limitations in addressing challenges such as voltage stress, inrush current, and input current continuity. To address these gaps, this study introduces a modified quasi-Z-source inverter (qZSI) structure employing a quasi-switched boost inverter (qSBI). The proposed inverter achieves a high boost factor with a minimal shoot-through interval and a high modulation index, ensuring superior performance. Key features include continuous input current, reduced voltage stress on switches, and negligible input voltage ripple, along with the elimination of initial inrush current typically associated with impedance source inverters. Comprehensive operational analyses and parameter-based comparisons with similar inverters confirm the advantages of the proposed design. Experimental validation demonstrates its accuracy and effectiveness, underscoring its potential to enhance renewable energy systems through improved performance and reliability.
Keywords: boost factor; inrush current; modulation index; switched boost inverter; quasi-Z-source inverter
Recurrence rates in dogs with GDV treated with gastric decompression versus dogs treated with gastric decompression and gastropexy
Authors: Zagan Costel 
Published: February 2025

Question
In dogs diagnosed with gastric dilatation and volvulus (GDV), does gastric decompression and gastropexy reduce the risk of recurrence of dilatation compared to dogs undergoing gastric decompression alone?

Clinical bottom line
Category of research:
Treatment.
Number and type of study designs reviewed:
Four papers were critically reviewed. Two papers were retrospective studies, and two were prospective.
Strength of evidence:
Strong.
Outcomes reported:
In dogs with GDV, the risk of recurrence of this disease was much lower when gastropexy was performed.
Conclusion:
The studies comparing the recurrence rates in dogs with GDV treated either with gastric decompression (with or without gastric repositioning) or with gastric decompression and gastropexy indicate that gastropexy will significantly reduce the risk of recurrence.
Keamanan dan Kualitas Makanan Pendamping ASI (MPASI) Ransum Bencana dengan Teknologi Pengemasan Retort Pouch
Authors: Nasrulloh Nanang , Fatmawati Iin , Mochni Richard Endang Srihari 
Published: February 2025

Latar Belakang: Bencana alam merupakan salah satu masalah yang sering terjadi. Bencana alam menyebabkan gangguan ketersediaan pangan, termasuk makanan pendamping ASI (MPASI). Oleh karena itu, diperlukan inovasi MPASI bentuk ransum darurat bencana dengan daya simpan lama dan aman dikonsumsi. Teknologi pengemasan retort pouch merupakan teknologi yang dapat digunakan untuk mengembangkan MPASI bentuk ransum dalam kondisi bencana.
Tujuan: Penelitian bertujuan mengevaluasi keamanan pangan dan kualitas MPASI yang dikemas menggunakan teknologi retort pouch selama periode penyimpanan tertentu.
Metode: Penelitian menggunakan metode desain eksperimental dengan rancangan acak lengkap (RAL) faktor tunggal. Adapun perlakuan adalah lama penyimpanan selama 7 hari, 14 hari, dan 21 hari dengan dua kali ulangan. Uji yaitu analisis kandungan gizi meliputi kadar air, karbohidrat, protein, lemak dan kadar abu serta aspek kemanan dengan pengujian total bakteri menggunakan metode cawan tuang (pour plate). Proses pembuatan MPASI yaitu formulasi bahan utama beras, telur, wortel, daun bawang dan mentega, selanjutnya dikemas dalam retort pouch, disegel dan disterilisasai suhu 121,5°C selama 15 menit. Data dianalisis menggunakan Analyisis of Variance (ANOVA) untuk menentukan signifikansi antar perlakuan.
Hasil: Hasil penelitian menunjukkan bahwa tidak ada pengaruh yang signifikan dari faktor perlakuan lama penyimpanan terhadap kandungan gizi yaitu kadar karbohidrat (p-value=0,272), protein (p-value=0,730), lemak (p-value=0,748), abu (p-value=0,848) dan kadar air (p-value=0,806). Demikian pula tidak ada pengaruh signifkan dari lama penyimpanan terhadap total bakteri yang nilainya masih dalam batas aman (<10 koloni/g).
Kesimpulan: Penggunaan retort pouch berpotensi meningkatkan masa simpan MPASI yang diperlukan dalam kondisi bencana sekaligus menjaga keamanan dan kualitas MPASI.
Efektivitas E-booklet Tentang ASI Eksklusif dalam Peningkatan Pengetahuan dan Sikap Ibu Hamil Trimester III
Authors: Purba Edy Marjuang , Sandy Yatty Destani , Damanik Kanaya Yori , Purba Saut , Nainggolan Anna Waris 
Published: February 2025

Latar Belakang: Pengetahuan dan sikap ibu hamil trimester III sangat berpengaruh terhadap keberhasilan pemberian ASI eksklusif. Masa ini menjadi waktu krusial bagi ibu dalam mempersiapkan kelahiran, termasuk pemahaman tentang makanan bayi. Dalam meningkatkan pengetahuan dan sikap, sebaiknya memilih media yang efektif serta sesuai dengan perkembangan teknologi seperti E-booklet.
Tujuan: Untuk menganalisis efektivitas E-booklet tentang ASI eksklusif dalam meningkatkan pengetahuan dan sikap ibu hamil trimester III di Wilayah Kerja Puskesmas Tuntungan.
Metode: Penelitian quasi-eksperimen ini menggunakan desain pre-test dan post-test with control group. Sebanyak 60 ibu hamil trimester III (30 orang kelompok eksperimen, 30 orang kelompok kontrol) dipilih melalui purposive sampling. Intervensi dilakukan dengan pemberian E-booklet selama dua minggu, kemudian diukur menggunakan uji Wilcoxon dan Mann-Whitney untuk mengetahui peningkatan pengetahuan dan sikap ibu hamil trimester III.
Hasil: Ibu hamil trimester III pada kelompok eksperimen dan kontrol mayoritas berusia 20-25 tahun (50,0% dan 56,7%), berpendidikan tinggi (73,3% dan 70,0%), memiliki paritas ≤2 (63,3% dan 66,7%), tidak bekerja (63,3% dan 56,7%), dan berpenghasilan tinggi (60,0% dan 56,7%). Kelompok eksperimen menunjukkan peningkatan rata-rata skor pengetahuan sebesar 5,70 (SD=2,57) dibandingkan kelompok kontrol 0,86 (SD=1,37). Rata-rata peningkatan skor sikap pada kelompok eksperimen sebesar 8,87 (SD=3,37) dibandingkan kelompok kontrol 1,43 (SD=3,65). Analisis menggunakan uji Mann-Whitney menunjukkan E-booklet secara signifikan meningkatkan pengetahuan dan sikap (p-value=0,001).
Kesimpulan: E-booklet terbukti efektif meningkatkan pengetahuan dan sikap ibu hamil trimester III tentang ASI eksklusif. Media ini dapat menjadi inovasi edukasi yang mendukung peningkatan cakupan pemberian ASI eksklusif di masyarakat.
Gender Disparities in Financial Inclusion: the Potential of Digital Loans in Empowering Female Health Entrepreneurs in Kenya
Authors: Ashubwe Jacklyne , Wanyama Maureen , Siyumbu Joseph , Zuijlen Ines van , Mutegi Nick , Verschuur Sabine , de Wit Tobias Rinke , Mulder Dorien , Janssens Wendy , Dieteren Charlotte 
Published: February 2025

Abstract

In Sub-Saharan Africa, female entrepreneurs are well-represented in healthcare but struggle to access financial services. Digital financing technologies could help close this gap. This study assessed the readiness, perspectives and gender disparities in (digital) loan characteristics among Kenyan health Small and Medium Enterprises (SMEs). We interviewed 24 and surveyed 410 health SME owners and analyzed loan-history data from 850 health SMEs to compare traditional and digital loans, focusing on gender disparities. IDIs identified low trust in digital lenders, while survey results indicated a strong demand for loans, regardless of gender. SME owners willing to take risks, with monthly financial needs and positive perceptions of digital loans were more likely to take a digital loan. Loan-history data showed a gender difference in the initial traditional loan amount, with women-owned businesses receiving less, but this gap disappeared for digital loans. Over 50% of women-led businesses using digital loans experienced significant growth, suggesting increased digital revenues linked to these loans. This study highlights the financing gap among Kenyan health SMEs and the potential of digital loans to enhance financial inclusion. Low trust in digital lenders, especially among those without direct experience, calls for better information dissemination to build confidence in digital financial products.
Fabrication of fusogenic and magnet-responsive cells for transplantation of an intact mitochondrial network
Authors: Xu Liqun , Li Xiao , Fan Xing , Yan Wei , Wu Wanfei , Li Junwei , Deng Ronghao , Zhu Haibao , Mao Aihua , Sun Pingnan , Zhang Xin , Xu Wencan , Chiju Wei 
Published: February 2025

Abstract

Background
Mitochondrial transplantation is a promising cure for many diseases associated with mitochondrial defects or ageing; however, a reliable method for mitochondria transfer is still in urgent need.
Method
In this study, we assembled fusogenic and magnet-responsive cells (FMRCs), which were enucleated stem cells loaded with Fe3O4 nanoparticles and further incorporated with fusogenic vesicular stomatitis virus glycoprotein G (VSV-G). Fusion was carried out in the presence of a magnetic force.
Results
Mitochondrial transplantation in the presence of a magnetic force via fusion from FMRCs restored normal mitotic activity, mitochondrial membrane potential, ROS levels and ATP production in cells containing partial mtDNA depletion, or in cybrids harboring mtDNA with a 4977-bp deletion. SNP tracing and qPCR analysis of the mitochondrial and nuclear genomes unequivocally demonstrated that exogenous mitochondria were able to reside stably and predominately. Mitochondria transplantation stimulated autophgy and thus the clearance of defective endogenous counterparts, resulted in lower mtDNA heteroplasmy.
Conclusion
The results suggest that FMRCs is an excellent vehicle for mitochondrial transplantation, which could be applied to the treatment of ageing and mitochondria associated diseases.
LTCONS_00014107-miR-29b-2-3p-GPR37 axis promotes heat stimulation induced esophageal carcinogenesis
Authors: Liu Wenting , Wang Jing , Qu Jiaping , Cheng Dan , Li Jiaqiong , Yeung Yiu To , Zhou Liting , Gao Yunfeng , Huang Hui , Dong Zigang , Li Xing 
Published: February 2025

Abstract

Esophageal cancer is a common malignant tumor of the digestive system, Esophageal squamous cell carcinoma (ESCC) is the major histological subtype of esophageal cancer. Multiple epidemiological evidence shows that consumption of hot temperature food and beverages is an important risk factor for developing ESCC, however, it is underlying mechanism remains unclear. Herein, for the first time, we constructed an animal model of esophageal precancerous lesions induced by heat stimulation in rats and simulated the human habit of eating hot food and drinks. Both LncRNA and miRNA expression of esophageal tissues were profiled by RNA-seq. We found LTCONS_00014107 was lowly expressed but miR-29b-2-3p was highly expressed in heat-induced ESCC and degradation of LTCONS_00014107 promoted the expression of miR-29b-2-3p since it is speculated that LTCONS_00014107 could be a precursor of miR-29b-2-3p. The functional study showed that knockdown miR-29b-2-3p could inhibit ESCC cell proliferation, whereas overexpression of miR-29b-2-3p could promote ESCC progression. Finally, through data analysis from the publicly available databases followed by verification using Dual-Luciferase assay, we found GPR37 could bind with miR-29b-2-3p and may be a potential target of miR-29b-2-3p. Overall, our research showed the function of LTCONS_00014107 in heat-induced ESCC and provided a theoretical and experimental basis of LTCONS_00014107-miR-29b-2-3p-GPR37 axis as the potential biomarkers and therapeutic targets in ESCC.
Navigating Chemical-Linguistic Sharing Space with Heterogeneous Molecular Encoding
Authors: Lv Liuzhenghao , Li Hao , Wang Yu , Yan Zhiyuan , Chen Zijun , Lin Zongying , Yuan Li , Tian Yonghong 
Published: February 2025

Abstract

Chemical language models (CLMs) are prominent for their effectiveness in exploring chemical space and enabling molecular design and engineering.
However, while exploring chemical-linguistic space, CLMs suffer from the semantic gap between natural language and molecular representations. This challenge is primarily due to the inherent modeling differences between molecules and texts: molecules operate unified modeling to learn chemical space, while natural language sequentially models their semantic space. Additionally, the limited availability of high-quality text-to-molecule datasets further exacerbates this challenge.
To address the problem, we first verified the information bias in molecular representations from different perspectives.
We then developed the Heterogeneous Molecular Encoding (HME) framework, a unified molecular encoder compressing the molecular features from fragment sequence, topology, and conformation with Q-learning.
To better model chemical-linguistic space, we further constructed the MCMoD dataset, which contains over one million molecules with various conditions, including properties, fragments, and descriptions.
Experimentally, HME promotes CLMs to achieve chemical-linguistic sharing space exploration from two aspects: (1) chemical space exploration with linguistic guidance, where HME achieves significant improvements (+37.8% FCD) for molecular design in multiple constraints, even in zero-shot learning scenarios; (2) linguistic space exploration with molecular guidance, where HME generates textual descriptions with high qualities (+11.6% BLEU) for molecules. These results highlight the precision of HME in handling multi-objective and cross-domain tasks, as well as its remarkable generalization capability on unseen task combinations.
HME offers a new perspective on navigating the chemical-linguistic sharing space, advancing the potential of CLMs in both fundamental research and practical applications in chemistry.