bluuebunny/crossref_metadata_2025_split huggingface dataset:
Withanone as an Emerging Anticancer Agent and Understanding Its Molecular Mechanisms: Experimental and Computational Evidence
Authors: Stephen Annatasha , Tune Bernadette Xin Jie , Wu Yuan Seng , Batumalaie Kalaivani , Sekar Mahendran , Sarker Md. Moklesur Rahman , Subramaniyan Vetriselvan , Fuloria Neeraj Kumar , Fuloria Shivkanya , Gopinath Subash C.B. 
Published: March 2024

Abstract:
Despite decades of research and effort, treating cancer is still a challenging task. Current
conventional treatments are still unsatisfactory to fully eliminate and prevent re-emergence or
relapses, and targeted or personalised therapy, which are more effective in managing cancer, may
be unattainable or inaccessible for some. In the past, research in natural products have yielded
some of the most commonly used cancer treatment drugs known today. Hence it is possible more
are awaiting to be discovered. Withanone, a common withanolide found in the Ayurvedic herb
Withania somnifera, has been claimed to possess multiple benefits capable of treating cancer. This
review focuses on the potential of withanone as a safe cancer treatment drug based on the pharmacokinetic
profile and molecular mechanisms of actions of withanone. Through these in silico and
in vitro studies discussed in this review, withanone showspotent anticancer activities and interactions
with molecular targets involved in cancer progression. Furthermore, some evidences also
show the selective killing property of withanone, which highlights the safety and specificity of
withanone in targeting cancer cell. By compiling these evidences, this review hopes to spark interest
for future research to be conducted in more extensive studies involving withanone to generate
more data, especially involving in vivo experiments and toxicity evaluation of withanone.
Antioxidant Activities and Phenolic Composition of Sarcococca saligna
Leaves
Authors: Sabir Syed Mubashar , Shahida Shabnam , Zeb Alam , Abbas Syed Rizwan , Hameed Muhammad Usman , Shanableh Abdallah , Khan Muhammad Imran , Ghernaout Djamel , Lajimi Ramzi Hadj , Elgharbi Sarra , Besbes Malek , Elboughdiri Noureddine 
Published: March 2024

Abstract:
Sarcococca saligna (D. DON) Muel is a vital plant with several steroidal alkaloids and is
effective against syphilis, liver diseases, gastrointestinal tract disease, infections, and inflammation.
The present study aimed to investigate the in vitro antioxidant activities and phenolic profile of S.
saligna. High-performance liquid chromatography (HPLC) analysis has shown the presence of
twelve phenolics namely kaempferol-3-O-glucoside, proanthocyanidin B1, quercetin-3-malonylglucoside-
7-glucoside, kaempferol-3-O-sophorotioside, Isorhamnetin-3-O-glucoside-7-O-rhamnoside,
kaempferolhexoside, 4-O-Caffeoyl-5-O-p-coumaroylquinic acid, 3,4-Di-O-caffeoyl-5-O-feruloylquinic
acid, 3,4-Di-O-feruloyl-5-O-caffeoylquinic acid, flavogalloyl-HHDP-gluconic acid (lagerstannin B),
3,4-di-O-caffeoylquinic acid and kaempferol-3-(caffeoyldiglucoside)-7-glucoside. The hot water
extract showed the highest anti-lipid peroxidative activities. The IC50 value for 2,2-diphenyl-1-
picrylhydrazyl (DPPH) radical scavenging activity was 71.5 ± 2.1 μg/mL. The extract could chelate
the iron and possess reducing activities on phosphomolybenum assay. It is concluded that extracts of
S. saligna are rich in antioxidants and contain essential phytochemicals.
Occurrence of Residual Breast Tumors and Efficacy of MRI in their Detection
after Vacuum-assisted Excisional Biopsy
Authors: Wei Qun , Zheng Qing , Gu Yifeng , Teng Rongyue , Zhao Wenhe 
Published: March 2024

Background::
Residual breast tumors may remain after vacuum-assisted excisional biopsy (VAEB).

Objective::
To determine the incidence of residual breast tumors in patients after VAEB and the efficacy of magnetic resonance imaging (MRI) in detecting
these tumors.

Methods::
This retrospective analysis examined patients who received VAEB before a diagnosis of breast cancer (BC) at our hospital from 2015 to 2019. The
incidence of residual tumors after VAEB was determined by MRI and pathological examination. The diagnostic value of MRI in detecting residual
tumors was determined for all patients and different subgroups. Logistic regression analysis was used to identify factors associated with residual
tumors.

Results::
We examined 147 patients and obtained pathological samples from 146 patients, including 103 (70.5%) with residual tumors and 43 (29.5%)
without residual tumors. The MRI examinations demonstrated the complete tumor resection rate was 48.9%. Compared to the pathological results,
MRI had a positive predictive value of 77.8%, negative predictive value of 48.8%, specificity of 65.6%, and sensitivity of 60.7%. Further analysis
indicated that MRI had moderate accuracies for patients with stage pT-1 (71.9%), stage pTNM-IA (73.1%), and luminal B subtype (78.3%). Binary
logistic regression analysis showed that the risk of tumor residue correlated with the pathological stage.

Conclusion::
Tumor residue is common after VAEB, and MRI has limited accuracy in detecting these residual tumors. However, for small breast tumors and
luminal B subtype BC, MRI had higher accuracy in the detection of residual tumors. The risk of tumor residue is closely associated with the
pathological stage.
Web-Based Therapist-Guided Mindfulness-Based Cognitive Behavioral Therapy for Body Dysmorphic Disorder: Pilot Randomized Controlled Trial
Authors: Kerry Camrie , Mann Prabhdeep , Babaei Nazanin , Katz Joel , Pirbaglou Meysam , Ritvo Paul 
Published: March 2024

Background
Internet-based cognitive behavioral therapy (CBT) and stand-alone mindfulness meditation interventions are gaining empirical support for a wide variety of mental health conditions. In this study, we test the efficacy of web-based therapist-guided mindfulness-based cognitive behavioral therapy (CBT-M) for body dysmorphic disorder (BDD), a psychiatric disorder characterized by preoccupations with perceived defects in appearance.

Objective
This study aims to determine whether CBT-M for BDD delivered on the web is feasible and acceptable and whether mindfulness meditation adds to CBT treatment effects for BDD.

Methods
In this 8-week, 2-arm, parallel pilot randomized controlled trial, n=28 adults (aged between 18 and 55 years) were randomly allocated to an experimental group (web-based therapist-guided CBT-M) or a control group (web-based therapist-guided CBT). Study retention, accrual, and intervention adherence were assessed, along with self-report measures for BDD, depression, anxiety, and pain intensity taken at baseline and postintervention.

Results
This study was feasible to implement and deemed acceptable by participants. After 8 weeks, significant improvements were found on all outcome measures for both treatment groups, and large between-group effect sizes favoring CBT-M were found for BDD symptom severity (d=–0.96), depression (d=–1.06), pain severity (d=–1.12), and pain interference (d=–1.28). However, linear mixed models demonstrated no significant differences between the groups over 8 weeks.

Conclusions
The results suggest that mindfulness meditation may add to beneficial web-based CBT treatment effects for BDD. An adequately powered randomized control trial of web-based CBT-M is warranted.

Trial Registration
ClinicalTrials.gov NCT05402475, http://clinicaltrials.gov/ct2/show/NCT05402475
Childhood Masturbation: A Case Report and Literature Review for Treatment
Authors: Lestari Ade Febrina , Sitaresmi Mei Neni , Ridhayani Firda 
Published: March 2024

Background: Masturbation is normal sexual behavior. However, masturbation in childhood is rarely discussed in the research. Childhood masturbation or gratification disorder, is characterized by self-stimulation of genitalia in prepubescent children. However, childhood masturbation often stops if the child is distracted, and spontaneous recovery within two years in most cases Generally, no drug therapy is required for childhood masturbation unless it is very frequent or excessive and it affects the daily functionality of the child. Regarding the treatment of childhood masturbation, we highlight the fact that evidence-based therapy for childhood masturbation is lacking due to unclear standard guidelines on it. We need a path of therapy that can help doctors in the management of childhood masturbation. Case: Here we reported two cases of excessive childhood masturbation from a 3-year-old and a 10-month-old female patient who were brought by their mother to the outpatient clinic pediatric, Academic Hospital, Universitas Gadjah Mada, Indonesia, with a complaint of stretching by flexing the legs and rubbing on her genital part Risperidone as one of the drug therapies for this case and present a good outcome. Additionally, this article also provides literature reviews on childhood masturbation treatment that may guide clinicians in its evaluation and management. Conclusion: We conclude that behavioral treatment is the common strategy for childhood masturbation. The treatment, as well as behavioral and drug therapeutic strategies, should be considered to achieve an effective outcome.
Niosomal Drug Delivery System used in Tuberculosis
Authors: Shanker Oma , Chanana Arsh , Gupta Pooja , Narayan Aditya , Kulkarni Yukta R. , Patel Akhilesh , Havelikar Ujwal , Mahato Bhabesh , Singh Ravindra Pal , Chawra Himmat Singh , Mishra Anurag 
Published: March 2024

Niosomes are artificially manufactured vesicles made of Cholesterol and Non-ionic surfactant. Their capacity to encapsulate a broad variety of pharmaceuticals and shield them from deterioration has piqued interest in drug delivery. Niosomes have demonstrated a possible use in the administration of anti-tuberculosis medications. Worldwide, tuberculosis is a serious public health concern. Even with advances in science and technology, tuberculosis remains a persistent problem.Niosomes can encapsulate anti-TB drugs, protecting them from enzymatic degradation and allowing for sustained release. Research in this field is on-going, with scientists working on optimizing niosomal formulations for tuberculosis treatment. It's important to consult current scientific literature for the latest advancements. Some anti-tubercular drugs face challenges in terms of absorption and bioavailability. Niosomal delivery systems can help address these issues. While niosomal drug delivery systems show promise, it's crucial to note that they are still an area of active research and specific formulations and protocols may vary. Patients should always consult with their healthcare providers for the most appropriate and up-to-date treatment options for tuberculosis. Niosomes can encapsulate both hydrophilic and lipophilic drugs, offering advantages such as increased drug stability, prolonged circulation time, controlled release, and targeted delivery. They have applications in various fields including pharmaceuticals, cosmetics, and agriculture.
Keywords: Tuberculosis, Niosomes, Drug delivery system
Synthesis and characterizations of Hg (II) Complex of Macrocyclic complexes compounds Tetradecahydrodibenzo hexaazacyclooctadecine with HgX2 (X= Cl, Br) by Hirshfeld analysis and antimicrobial activity
Authors: Jaiswal Amit , Pal Anil Kumar , Sahu Dharmendra Kumar , Kumar Ranjeet 
Published: March 2024

This study examines the synthesis and characterization of a macrocyclic complex molecule having the general formula [M-LX2], where M =Hg (II) with schiff base Tetradecahydrodibenzo hexaazacyclooctadecine ligands. Resulted from the interaction between mercury and the diethyl triamine and benzene- 1, 2 diol in an ethanolic solution. Schiff base and its novel mercury (II) Complexes were studied vibrational in the solid state using spectral, 1H-NMR, IR, UV, and antimicrobial activity approaches. We were able to establish the coordination mode of the metal in complexes by comparing the changes in the ligands' and complexes' FT-IR and UV-Visible spectra.
Keywords: MERCURY (II), Schiff bases, IR, 1H-NMR, PXRD Spectroscopy.
The Correlation Between Stigma and Mental Health Disorders in People Living with HIV/AIDS
Authors: Dave Pallav 
Published: March 2024

Stigma remains a significant challenge for people living with HIV/AIDS(PLWHA) despite the advances that have been made in HIV care and treatment. It is known to affect health care outcomes including care seeking habits and medication adherence. In addition to contributing to poor health outcomes, stigma is known to increase the risk of developing mental health disorders. Various researchers have found a correlation between stigma and mental health disorders including depression, anxiety, mental distress, stress, post-traumatic stress disorder (PTSD), and suicidal ideation. The aim of this review is to explore the association between stigma and mental health disorders in PLWHA. It identifies common mental health disorders found in people living with HIV and how these disorders are linked to stigma. The review also identifies how stigma and mental health disorders affect healthcare outcomes of PLWHA. The review concludes by providing a number of measures that can help to end stigma and improve overall health outcomes of PLWHA.
Keywords: stigma, HIV-related stigma, HIV/AIDS, mental health disorders, people living with HIV/AIDS
Aproximación a las nuevas dinámicas del Modelo Bancario Tradicional en Colombia frente al Modelo Fintech. 2021
Authors: Vega Zuluaga Juan David , Restrepo Calle Luis Fernando 
Published: March 2024

El propósito de la presente investigación es realizar una aproximación a las nuevas dinámicas del Modelo Bancario Tradicional en Colombia Frente al Modelo Fintech, revisando fuentes primarias y secundarias actualizadas sobre el tema, atendiendo a la opinión de expertos en el tema disponibles en la web, construyendo finalmente un posible rumbo o dinámica del sector en Colombia. La investigación es de carácter descriptivo y para el logro de los objetivos propuestos se utilizaron dos instrumentos de recolección de información, como son el análisis de la opinión de expertos en el área de fintech, y la observación directa de los indicadores de los entes de control y supervisión, así como de las empresas que conforman el ecosistema local. Se logra determinar que la aparición de las fintech del sector financiero, originan una relación colaborativa, complementaria o asociativa, de acuerdo a las particularidades de cada Startup, y permiten una manera diferente de presentar y ofrecer un nuevo portafolio de servicios de las entidades financieras tradicionales y con décadas de presencia en el mercado. Así mismo, la masificación del internet, la creciente interacción en la red, la reducción de costos y gastos operativos en sus procesos, se convierte en la mayor de sus ventajas, siendo catapultadas algunas fintech del sector financiero por la pandemia. El interés de la banca tradicional frente a las fintech es mutuo, pues la unión de las dos se convierte en una fuente de ventaja competitiva en el mercado financiero cuando se logra una integración efectiva entre las necesidades de uno (banca tradicional) y los desarrollos tecnológicos y conectividad del otro (las fintech). Con relación a los beneficios y riesgos de la llegada de las fintech a Colombia, se considera que algunos de los mayores beneficios están relacionados con las diferentes técnicas de verificación de identidad y así evitar el desplazamiento a las diferentes entidades y sucursales financieras por parte de los usuarios. Otro de los beneficios que han ayudado a la consolidación de las fintech, está relacionado con el tiempo de activación de un producto o servicio financiero, que es menor en las fintech y con menos tramitología.
La nueva realidad: microempresarios casanareños frente al primer año de convivencia con el COVID-19. Instrumento de diagnóstico, análisis de impacto e identificación de estrategias innovadoras para la recuperación del sector.
Authors: Gonzalez Villar Armando , Martínez Vargaz Magda Yolima 
Published: March 2024

El proyecto busca generar innovación, investigación y desarrollo tecnológico para el Centro Agroindustrial, y Fortalecimiento Empresarial de Casanare, la comunidad educativa, los microempresarios de la región y la comunidad en general, a través de la elaboración del diagnóstico que nos permita caracterizar el sector microempresarial del área urbana y rural del departamento, e identificar las principales afectaciones en materia de ventas y empleo, ante la contingencia del covid-19 y su impacto generado en el tejido microempresarial, un año después de su convivencia, teniendo en cuenta que para la reactivación económica se requieren esencialmente estrategias concretas que logren incrementar el capital de trabajo y la adopción de modelos de negocio flexibles, modernos y adaptados en el sector microempresarial como principal fuente de empleo.
Security and Human Rights in Eastern Europe. New Empirical and Conceptual Perspectives on Conflict Resolution and Accountability
Authors: Poulsen Niels Bo 
Published: March 2024

Security and Human Rights in Eastern Europe. New Empirical and Conceptual Perspectives on Conflict Resolution and Accountability samler bidrag fra et projekt foretaget i 2021 ved Stockholm Centre for Eastern European Studies. Projektet, som analyserede forskellige aspekter af menneskerettigheder og sikkerhed i Østeuropa, blev igangsat for at understøtte det svenske OSCE-formandskab samme år.
Security and Human Rights in Eastern Europe. New Empirical and Conceptual Perspectives on Conflict Resolution and Accountability is an anthology of contributions from a project carried out in 2021 at the Stockholm Center for Eastern European Studies. The project, which analyzed various aspects of human rights and security in Eastern Europe, was initiated to support the Swedish OSCE chairmanship in the same year.
Prospects of the Bug mining district as an agglomeration of ore and non-ore mineral deposits for the reconstruction of the national economy of Ukraine in the post-war period
Authors: Yentin V.A. , Gintov O.B. , Mychak S.V. , Pavlyuk V.N. , Nikolaevsky V.P. 
Published: March 2024

The role and capabilities of Ukrainian geological science, production and investment capital in the reconstruction of the national economy of Ukraine during the war and post-war period are considered here using the example of the Bug mining district (BMD) of the Ukrainian Shield (USh).
BMD is characterized by an extremely wide range of deposits and ore of minerals relatively close to the surface, among which the most important ones are graphite, iron ore and iron-manganese, nickel-chromium-cobalt deposits, deposits and ore occurrences of gold discovered by geologists and geophysicists for many years. Numerous deposits of building materials and kaolin are also known here. There are prospects for obtaining local agrochemical raw materials based on the development of apatite-containing ores and calcifers.
The article lists and shows the location of mineral deposits and ore occurrences which arethe most well-prepared for industrial development and investments. The composition of ores and the content of useful substances are given for some of them.
Two powerful industrial enterprises are located on the BMD square, i.e., the Zavallye graphite factory and the Bug ferronickel plant (currently repurposed for other products). They can be used to process the above-mentioned ore raw materials, with some improvement of technological processes. In this regard, the possibility and practicality of creating two centers (clusters) of integrated mining and industrial development of these useful resources were considered. One of them can be created on the basis of nickel-cobalt and iron ore deposits of BMD with an orientation towards the Bug ferronickel plant. The second center can be created based on the enrichment of iron-manganese oxide ores using the technical capabilities of the Zavallye graphite plant.
In case of realization of the entire economic potential of the industrial development of graphite ores of the region, Ukraine could become a world leader in this field and receive significant funds to reconstruct the industry disrupted by the war.
The BMD also meets all the geological and economic prerequisites to become the first region on the Ukrainian Shield for industrial gold mining.
The correctness of the finite-difference problems of the time- and wave fields continuation for the migration image of the basement boundary
Authors: Verpakhovska O. , Chorna O. 
Published: March 2024

In modern seismic exploration, the migration procedure plays an important role for further interpretation of the observed data. It is the migration that makes it possible to display the deep structure of the geological section based on the dynamic characteristics of the registered wave fields.
When processing WARRP (wide angle reflection/refraction profiling) seismic data, standard migration methods are ineffective, which is due to the peculiarities of observation systems. All existing migration methods are mainly based on reflected waves, which have a limited registration interval. The wave field on WARRP is observed at distances from sources that reach several hundred kilometers, and the uneven step between receivers is on average 1—3 km. Under such conditions, it is difficult and sometimes impossible to separate the reflected waves.
The finite-difference reflection/refraction migration developed at the Subbotin Institute of Geophysics of the National Academy of Sciences of Ukraine has proven its effectiveness in constructing migration images of the depth structure of the section based on WARRP data observed in various regions of the world. The main difference of this migration method is the use of refracted waves as reference waves registered in the large offsets. At the same time, there is a question of the correctness of the reproduction of the depth structure of the section on the migration image, which depends on the correctness of the calculation methods. The algorithm of finite-difference reflection/refraction migration contains a continuation of the time and wave fields.
The article presents a proof of the mathematical correctness of the solution of the eikonal differential equations and the scalar wave equation by the finite-difference method, on which are based the continuation of the time and wave fields, respectively.
The given comparison of the formed migration images and the velocity models, calculated by the ray-tracing method, of the upper crust along the PANCAKE and TTZ-South profiles allows us to assert that the combination of the results of kinematic and dynamic processing of WARRP data allows to increase the informativeness of their further interpretation