bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Concomitant Cardiac Surgical Procedures Performed During Pediatric Lung Transplantation in the United States
Authors: Ramineni Aadhyasri , Faateh Muhammad , Mehdizadeh-Shrifi Amir , Hayes Don , Morales David L. S. 
Published: April 2024

Abstract

Data on concomitant cardiac surgery (CCS) performed during pediatric lung transplantation (LTx) is limited. Therefore, we conducted a multi-institutional analysis to identify the incidence and outcomes of CCS in pediatric (< 18 yrs) LTx recipients by merging data (2004–2023) from the United Network for Organ Sharing (UNOS) and Pediatric Health Information System (PHIS) databases. Of the total of 596 pediatric LTx recipients, 87 (15%) underwent CCS. The majority were atrial septal defect (ASD) closure (90%) followed by aortic arch/descending aortic repair (3%), atrial repair (3%), ventricular septal defect closure (2%), patent ductus arteriosus ligation (2%), and tricuspid valve repair (2%). The median age at LTx was 3 years (IQR:0–12). Pulmonary hypertension (PHT) was the predominant indication for LTx (54%). In-hospital mortality was 6% and 5-year mortality was 64%. Importantly, CCS in children undergoing LTx has acceptable outcomes.
Impact of mineral oil lubricant from rotary instrument on osseointegration and surface contamination of dental implants: An in vivo rabbit tibia study
Authors: Kim Heon-Young , Jang Il-Seok , Song Ju-Dong , Kim Sun-Jong , kim Jin-Woo 
Published: April 2024

Abstract

Background: The success of osseointegration in dental implants is largely influenced by the surface characteristics, including texture, chemistry, and cleanliness. This study investigates the effect of a rotary instrument mineral oil lubricant on the osseointegration of dental implants in the rabbit tibia, addressing concerns about lubricant-induced surface contamination from dental handpieces.
Methods: We used six New Zealand rabbits and inserted two implants per tibia in each animal for a total of 24 implants. Each group was further divided into two rabbits: the first group was placed with no lubricant used in the fixture and hand-piece (control); the second group was placed in the fixture after the recommended management of the handpiece; and the third group was placed in a lubricant-soaked fixture. Two weeks and four weeks later, the rabbits were euthanized. The removal torque and bone-implant contact were measured by histomorphometric examination.
Results: Although an inverse relationship was observed between the fixture contamination severity and removal torque, the correlation was not statistically significant. In contrast, a clear decrease in bone-implant contact was noted with increased levels of contamination, with this effect being statistically significant at the 4-week.
Conclusion: Even if a handpiece is used for a short duration, difficulties in controlling lubricant expulsion can pose problems for bone osseointegration of the implant. Therefore, a thorough expulsion process is necessary after oiling, and during implant drilling and placement, meticulous cleaning and suction should be employed to minimize the amount of residual oil on the implant.
CR prosthesis or PS prosthesis, which one is closer to the natural rollback of the knee joint? ——A vivo kinematics study using Mako robot-assisted im-based-system measurement
Authors: Huang Yijian , Zhao Fangxin , Wang Cheng , Xie Hongbin , Gao Zhisen , Kong Xiangpeng , Li Xiang , Chai Wei 
Published: April 2024

Abstract
Background
Cruciate-retaining (CR) prosthesis and posterior-substituting (PS) prosthesis are widely used in total knee arthroplasty (TKA). The main discrepancy in kinematics between two designs is that the mechanism of rollback motion during knee flexion is different. In this study, by using image-based robotic assisted system (mako), femoral-tibial contact points of these two types of prostheses during 0°to 140°flexion were recorded to compared with the natural kinematic characteristics of knee joints before TKA, so as to explore which type of prosthesis is close to the natural rollback.
Method
Twelve patients (15 knees) with MAKO-assisted TKA in our center were included. ①After the registration was completed, the knee joint of the patients was flexed at 0°to 140°(10°increasing, A total of 16 angles, including 45°), the contact point of femur and tibia at each angle was recorded by Mako software; ②After the anterior cruciate ligament(ACL) removed and the posterior cruciate ligament(PCL) retained, the CR model was placed, and the contact point of the femur and tibia at each knee flexion angle was recorded again from 0°to 140 °;③The PCL was removed, and the PS prosthesis was implanted finally. Then the contact position of the femur and tibia at each knee flexion angle from 0°to 140 °was recorded for the third time. Through the above process, we obtained the contact position of the femoral condyle and the tibia during the passive flexion of the knee joint at 16 angles in three conditions (1, the patient with natural knee; 2, the patient with CR prosthesis;3, the patient with PS prosthesis) in order to simulate the rollback of the knee joint and compare the difference of rollback in three groups.
Results
There was no statistical difference in contact points of the femur and tibia between the CR prosthesis and the natural knee at all 16 flexion angles (P > 0.05). The contact points of the femur and tibia in the PS prosthesis group was close to those of the natural knee at flexion range from 20 ~ 50°(P > 0.05); but at 0 ~ 10°flexion and 60 ~ 140°flexion, there was a statistical difference in contact points of the femur and tibia between the PS prosthesis group and the patient 's natural knee joint(P<0.05).
Conclusion
By using the intraoperative real-time positioning function of image-based robotic assisted system(Mako)to detect the characteristics of knee joint rollback motion, we found that compared with PS prosthesis, the knee joint rollback of patients using CR prosthesis was closer to the natural state.
A study protocol to assess the effectiveness of tocotrienol-rich fraction in older adults : a randomised, double-blind, placebo-controlled
Authors: Goon Jo Aan , Ngah Wan Zurinah Wan , Makpol Suzana , Damanhuri Mohd Hanafi Ahmad , Ibrahim Nor Faeizah , Ghazali Nur Izyani , Rais Rahimah Zahidah Mohd , Chin Kok Yong , Aminuddin Amilia , Yunus Mohd Heikal Mohd , Man Munirah Md , Neo Juvenia Rui En , Loong Hsieu Yen , Ung Yee Wei , Yap Wei Ney 
Published: April 2024

Abstract

Background
Tocotrienol, a naturally occurring form of vitamin E, has been extensively studied for its potent antioxidant, anti-inflammatory, and immune-stimulating properties. However, the clinical impact of tocotrienol supplementation on older adults' overall health and well-being remains relatively unexplored. This research aims to investigate the efficacy of tocotrienol-rich fraction (TRF), on various health parameters associated with general well-being in individuals aged between 50–75 years.
Methods
The present study is a randomised, double-blind, placebo-controlled trial designed to investigate the effectiveness of TRF supplementation on overall health in healthy elderly individuals. The study aims to assess the impact of a daily dosage of 200mg of TRF over a period of 6 months. A total of 220 participants are enrolled in the study, with half receiving the placebo and the other half receiving TRF supplementation. The study comprises three endpoints: baseline, 3 months, and 6 months. At each endpoint, various measurements are taken to evaluate different aspects of health. These measurements include blood biochemistry assessments such as liver function tests, renal profile, lipid profile, and full blood count. Oxidative stress markers, including malondialdehyde, advanced glycation end-products, protein carbonyl, and isoprostane, are also evaluated. Immune response markers such as interleukin-6 and tumour necrosis factor-alpha are assessed. Satiety regulation is examined through measurements of leptin and ghrelin. Body composition and skin health parameters, including wrinkling, pigmentation, elasticity, hydration, and sebum secretion, are evaluated. Additionally, arterial stiffness is assessed by arteriography, bone mineral density is measured using dual x-ray absorptiometry, and cognitive function is assessed through the Montreal Cognitive Assessment, Rey Auditory Verbal Learning Test, and digital span, are measured at baseline and at the 6-month endpoint.
Discussion
By comprehensively evaluating these health aspects, this study seeks to provide valuable insights into the potential benefits of tocotrienol supplementation for promoting the overall health and well-being of the ageing population.
Trial registration
National Medical Research Register (NMRR), no. NMRR19-2972-51179
Enhancing Fluid Viscous Damper Design in High-Rise Buildings through Direct Soil Structure Interaction Approach
Authors: Hamza Ameer , Hammad Muhammad , Khokhar Sikandar Ali , Ali Faizan , Haider Abbas 
Published: April 2024

Abstract

The application of fluid viscous dampers (FVDs) in high-rise buildings is increasing rapidly, driven by their effectiveness during seismic excitations. However, conventional design using fixed base or indirect soil structure interaction (SSI) approaches often leads to unrealistic results due to underestimated seismic demands. This study proposes a novel approach for the optimum design of FVDs incorporating direct SSI modeling for high-rise buildings. For this purpose, a 40-story case study building is selected along with the existing underlying soil. A detailed nonlinear finite element model (FEM) was developed for the superstructure and the underlying subgrade using direct SSI approach. For comparative study, two FVDs based models were developed: one designed based on seismic demands from a fixed base model, and the other utilizing the seismic demands from the direct SSI approach. These inelastic computer models were subjected to nonlinear time history analysis, employing three deconvoluted ground motions, to compare their seismic performance. The results show that the design of FVDs considering direct SSI approach can help lower the story drifts and displacements by up to 36% and increase energy dissipation by dampers by up to 10% compared to the conventional approach. The results emphasize the critical significance of adopting direct SSI modeling for achieving the optimal design of FVDs for the resilience of high-rise building structures.
Effectiveness of Acceptance and Commitment Therapy for distressed family caregivers of patients with dementia: a case control study
Authors: Gwak Jiyoung , Park Jinse 
Published: April 2024

Abstract
Background: Recently, psychoeducational support to caregivers of patients with dementia (CPWD) has been much interested. Acceptance and commitment therapy (ACT) which accept negative thought has been arising as a next generation of CBT. Here, we investigate the effect of ACT on emotional stress of caregivers of patients with dementia.
Method: The family caregivers of patients who have behavioral psychomotor symptom in dementia were recruited in this study. 13 intervention group and 13 control group were analyzed. The participants in experimental group were underwent a 6-week ACT program in one on one, face to face format. The outcome measurement are Beck anxiety inventory (BAI), Beck depression inventory-Ⅱ (BDI-Ⅱ), Zarit burden inventory (ZBI) and acceptance action questionnaire-16 (AAQ-16).
Results: In experimental group, the score of BAI, BDI-Ⅱ, ZBI and AAQ-16 significantly improved compared to baseline score. The difference of the change of the score of BAI, BDI-Ⅱ and ZBI after ACT program showed significant difference between intervention and control group. The change of BDI-Ⅱ significantly correlated with the changes of AAQ-16
Conclusion: The result of this study showed that the depression, anxiety, and caregiver burden markedly reduced in intervention group compared to control group. The change of depression is correlated with the change of the degree of acceptance. Our results support that ACT can be useful counselling program for caring of family CPWD.
Elimination effect of electrotherapy and cold therapy combined with chemotherapy on apple scar skin viroid on in vitro apple plants
Authors: Hu Guojun , Dong Yafeng , Zhang Zunping , Fan Xudong , Ren Fang 
Published: April 2024

Abstract

Apple scar skin viroid (ASSVd) and other apple viruses [apple chlorotic leaf spot virus (ACLSV), apple stem-pitting virus (ASPV), and apple stem grooving virus (ASGV)] can cause significant economic losses to the apple industry. We used ASSVd- and ASGV-infected Malus pumila ‘Spy 227’ and ACLSV-, ASPV-, and ASGV-infected Malus ‘Gala’ apple plants as the plant materials for virus elimination experiments. We evaluated the viral elimination effectiveness of electrotherapy at different electric current intensities and treatment durations on in vitro plants of the two apple cultivars. Furthermore, the effect of cold therapy (4°C) combined with ribavirin (25 µg/mL) at different treatment durations on Spy 227 plants was investigated. All shoot tips of the two cultivars sterilized with 75% alcohol or 0.1% mercury bichloride grew normally after treatment with an electric current. Spy 227 plants treated with cold therapy combined with ribavirin started to die after 50 days of treatment, and the death rate increased with the extension of treatment time. Quantitative reverse-transcription PCR (qRT-PCR) and RT-PCR were used to detect the viroid and viruses in regenerated plants. The results showed that electrotherapy did not inhibit ASSVd, ACLSV, ASGV, or ASPV. Moreover, cold therapy combined with ribavirin had no eliminating effect on ASSVd, but the elimination rate of ASGV under treatment periods of 80 d and 95 d was 60.4% and 60.1%, respectively. Considering the impact of ASSVd on apple plant health, additional methods are necessary to effectively remove this viroid.
Successful eradication of an environmental reservoir of NDM-producing Klebsiella pneumoniae associated with nosocomial transmissions in a low-incidence setting
Authors: Moulin Estelle , Filippidis Paraskevas , Paire-Ficout Corinne Aymon , Blanc Dominique S. , Grandbastien Bruno , Senn Laurence 
Published: April 2024

Abstract

Background
The hospital wastewater system has been reported as a source of nosocomial acquisition of carbapenemase producing Enterobacteriaceae(CPE) in various settings. Cleaning and disinfection protocols or replacement of contaminated equipment often fail to eradicate these environmental reservoirs, which can lead to long-term transmission of CPE. We report a successful multimodal approach to control a New Delhi metallo-beta-lactamase positive Klebsiella pneumoniae (NDM-KP) nosocomial outbreak implicating contamination of sink traps in a low-incidence setting.
Methods
Following the incidental identification of NDM-KP in a urine culture of an inpatient, we performed an epidemiological investigation, including patient and environmental CPE screening, and whole genome sequencing (WGS) of strains. We also implemented multimodal infection prevention and control (IPC) measures, namely the isolation of cases, waterless patient care, replacement of contaminated sink traps and connecting pieces, and bleach and steam disinfection of sinks for 6 months, followed by patient and environmental screenings for eradication.
Results
Between February and May 2022, five NDM-KP cases were identified in an eight-bed neurosurgical intermediate care unit. Among the eight sink traps of the unit, three were positive for NDM-KP. Patient and environmental isolates belonged to multilocus sequence typing ST-268. All isolate genomes were genetically very similar suggesting cross-transmission and a potential role of the environment as the source of transmissions. Thanks to the combined IPC measures, no new case was subsequently detected, and sink traps remained negative for NDM-KP within 6 months after the intervention.
Conclusion
The implementation of multimodal IPC measures, including waterless patient care combined with the replacement and disinfection of sink traps and connecting pieces, was successful in the eradication of NDM-KP after eight months. In a low-incidence setting, this approach has made it possible to pursue the objective of zero transmission of carbapenemase-producing Enterobacteriaceae (CPE).
Effect of nursing intervention based on 6S management model on negative emotions and surgical stress in patients with gastric cancer
Authors: Dong Cuiling , Jiang Yun 
Published: April 2024

Abstract
Objective To study the effect of nursing intervention under the 6S management model on preoperative negative emotions and surgical stress in patients with gastric cancer. Methods A total of 160 patients diagnosed with gastric cancer were enrolled in this study and randomly assigned to either an experimental group (80 cases) or a control group (80 cases). The experimental group underwent individualized nursing intervention following the 6S management model (6S nursing), while the control group received routine nursing care. The Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) were utilized to evaluate the patients' negative emotions. The study compared the preoperative HAMA and HAMD scores, preoperative blood pressure, postoperative 24-hour neutrophil-to-lymphocyte ratio (NLR), and 24-hour C-reactive protein (CRP) levels between the two groups. Results Following nursing intervention, both groups exhibited significantly lower preoperative HAMA and HAMD scores compared to admission scores (P < 0.05). Moreover, the experimental group demonstrated a more pronounced reduction in both HAMA and HAMD scores (P < 0.05). Additionally, the experimental group displayed lower preoperative systolic blood pressure in comparison to the control group, with postoperative 24-hour NLR and 24-hour CRP levels also being lower in the experimental group (P < 0.05).. Conclusion Nursing intervention under the 6S care effectively alleviates preoperative negative emotions and reduces surgical stress in patients with gastric cancer, providing a comfortable perioperative environment for patients.
Mortality and Extrauterine Growth Restriction of Necrotizing Enterocolitis in Very Preterm Infants with Heart Disease: A Multi-Center Cohort Study
Authors: Lu Pei , Gong Xiaohui , Gu Xinyue , Jiang Siyuan , Cao Yun , Sun Chengjun , Du Juan , Lei Xiaoping , Lee Shoo K. 
Published: April 2024

Abstract

OBJECTIVE. Congenital heart disease (CHD) and patent ductus arteriosus (PDA) are risk factors of necrotizing enterocolitis (NEC) in infants. However, it is unclear whether the prognosis of NEC is different between very preterm infants (VPIs) with and without heart diseases.
PATIENTS AND METHODS. This was an observational cohort study that enrolled VPIs (born between 24+ 0 and 31+ 6 weeks) admitted to 97 tertiary neonatal intensive care units (NICU) in the Chinese Neonatal Network (CHNN) between 2019 and 2021. The exposure was CHD or isolated PDA, and VPIs with NEC were divided into three groups: complicated with CHD, with isolated PDA, and without heart diseases. The primary outcomes were NEC related adverse outcomes (death or extrauterine growth restriction (EUGR)). Logistic regression models were used to adjust potential confounders and calculate the odds ratios (ORs) and 95% confidential intervals (CIs) for each outcome.
RESULTS. A total of 1335 VPIs with NEC were enrolled in this study, including 65 VPIs with CHD, 406 VPIs with isolated PDA. The VPIs with heart diseases had smaller gestational ages and lower body weights at birth, more antenatal steroids use, and requiring inotrope prior to the onset of NEC. While suffering from NEC, death or EUGR were more often observed in VPIs with either CHD (aOR: 2.07; 95% confidence interval [CI]: 1.20–3.60) or isolated PDA (aOR: 1.51; 95% CI: 1.17–1.94) than those without heart diseases. While no significant increased risks in NEC related death in VPIs with either CHD (adjusted OR [aOR]: 1.10; 95% CI: 0.41–2.50) or isolated PDA (aOR: 1.25; 95% CI 0.82–1.87), increased risks in EUGR was identified in either survival VPIs with CHD (aOR: 2.35; 95% CI: 1.31–4.20) or isolated PDA (aOR: 1.53; 95% CI: 1.16–2.01) in survivors. VPIs with either CHD or isolated PDA were associated with significantly prolonged duration of fasting, extended time to achieve full enteral feeding, longer ventilation duration and hospitalization duration. Similar characteristics were also seen in VPIs with isolated PDA, with the exception that VPIs with CHD are more likely to undergo surgical intervention and maintain a prolonged fast after NEC.
CONCLUSIONS. In VPIs with NEC, CHD and isolated PDA are associated with an increased risk in worse outcomes. We recommend that VPIs with cardiac NEC be managed with aggressive treatment and nutrition strategies to prevent EUGR.
Characterization of the complete chloroplast genome and development of molecular markers of Salix
Authors: wang pu , Guo Jiahui , Zhou Jie , wang yixuan 
Published: April 2024

Abstract

Salix is an economically and ecologically multi-functional tree species widely distributed in China. The five species sequenced in this study are of great ornamental value and suitable for plant phytoremediation owing to their ability to absorb heavy metals. Based on high-throughput sequencing to obtain chloroplast genome sequences of Salix, analyze their gene composition and structural characteristics, explore potential molecular markers, and provide a theoretical basis for willow identification and resource classification. Using the leaves of S. argyracea, S. dasyclados, S. eriocephala, S. integra 'Hakuro Nishiki', and S. suchowensis as materials, an improved CTAB method was used to extract chloroplast DNA. The Illumina Nova seq PE150 platform was used for sequencing, and bioinformatics methods were used to compare the structural characteristics and degree of variation of chloroplast genomes in willow species. The chloroplast genome sequences of five willow are highly similar, SSR analysis was performed on the chloroplast genomes of five species, resulting in 276, 269, 270, 273, and 273 SSR loci, respectively. Unique simple repeat sequences were found in each variety. Comparative chloroplast genome analysis of 22 Salix species, it was found that there are differences in the matK-trnQ, ndhC-trnV, psbE-petL, rpl36-rps8, and ndhB-rps7 regions, which can serve as molecular markers for willow resource classification research. We have established an analysis method suitable for chloroplast genome sequencing and structural characteristics of Salix, which enriches the genetic resources of Salix and provides a theoretical basis for the development of molecular markers and the study of interspecific phylogeny in Salix.