bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of a hybrid telehealth care pathway for patients with axial spondyloarthritis including self-sampling at home: results of a longitudinal proof-of-concept mixed-methods study (TeleSpactive)
Authors: Labinsky Hannah , May Susann , Boy Katharina , von Rohr Sophie , Grahammer Manuel , Kuhn Sebastian , Rojas-Restrepo Jessica , Vogt Ekaterina , Heinze Martin , Schett Georg , Muehlensiepen Felix , Knitza Johannes 
Published: April 2024

AbstractPatients with axial spondyloarthritis (axSpA) require close monitoring to achieve the goal of sustained disease remission. Telehealth can facilitate continuous care while relieving scarce healthcare resources. In a mixed-methods proof-of-concept study, we investigated a hybrid telehealth care axSpA pathway in patients with stable disease over 6 months. Patients used a medical app to document disease activity (BASDAI and PtGA bi-weekly, flare questionnaire weekly). To enable a remote ASDAS-CRP (TELE-ASDAS-CRP), patients used a capillary self-sampling device at home. Monitoring results were discussed and a decision was reached via shared decision-making whether a pre-planned 3-month on-site appointment (T3) was necessary. Ten patients completed the study, and eight patients also completed additional telephone interviews. Questionnaire adherence was high; BASDAI (82.3%), flares (74.8%) and all patients successfully completed the TELE-ASDAS-CRP for the T3 evaluation. At T3, 9/10 patients were in remission or low disease activity and all patients declined the offer of an optional T3 on-site appointment. Patient acceptance of all study components was high with a net promoter score (NPS) of +50% (mean NPS 8.8 ± 1.5) for self-sampling, +70% (mean NPS 9.0 ± 1.6) for the electronic questionnaires and +90% for the T3 teleconsultation (mean NPS 9.7 ± 0.6). In interviews, patients reported benefits such as a better overview of their condition, ease of use of telehealth tools, greater autonomy, and, most importantly, travel time savings. To our knowledge, this is the first study to investigate a hybrid approach to follow-up axSpA patients including self-sampling. The positive results observed in this scalable proof-of-concept study warrant a larger confirmatory study.
Effects of soil water content at freezing, thaw temperature, and snowmelt infiltration on N2O emissions and denitrifier gene and transcript abundance during a single freeze-thaw event
Authors: Sennett Louise B. , Brin Lindsay D. , Goyer Claudia , Zebarth Bernie J. , Burton David L. 
Published: April 2024

AbstractClimate change-related warming and increased precipitation may alter winter snow cover and thawing events, and therefore, may carry significant consequences for nitrous oxide (N2O) production pathways such as denitrification, and the abundance and expression of denitrifying microorganisms. We used a soil microcosm study to investigate the combined effect of soil thaw temperature, initial water filled pore space (WFPS) prior to soil freezing, and snowmelt infiltration simulated by the addition of water on N2O emission and denitrification rates, soil respiration rate, and the abundance and transcription of denitrifying (nirK, nirS, and nosZ) bacteria during a single freeze-thaw event. Soil respiration rate was primarily controlled by an increase in soil thaw temperature, whereas soil N2O emission and denitrification rates were generally greater in soils with a higher initial WFPS and soil thaw temperature. In contrast, snowmelt infiltration generally had a negligible effect on these rates, which may be related to pre-existing soil conditions that were already conducive to denitrification. Unexpectedly, the nosZ transcript/nosZ gene abundance ratio was lower in soils thawed at 8.0 °C compared to 1.5 °C; however, this may have resulted in a lower N2O reduction, thus explaining the greater levels of N2O emitted from soils thawed at 8.0 °C. Overall, this study demonstrated that increased N2O production during a single freeze-thaw event was primarily linked to antecedent conditions of high initial WFPS, soil thaw temperature, and a synergistic interplay between these two environmental parameters, and provides evidence that an increase in annual temperature and precipitation, along with the timing of precipitation, may further stimulate N2O production pathways.
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment
Authors: von Haehling Stephan , Assmus Birgit , Bekfani Tarek , Dworatzek Elke , Edelmann Frank , Hashemi Djawid , Hellenkamp Kristian , Kempf Tibor , Raake Philipp , Schütt Katharina A. , Wachter Rolf , Schulze Paul Christian , Hasenfuss Gerd , Böhm Michael , Bauersachs Johann 
Published: April 2024

AbstractThe aetiology of heart failure with preserved ejection fraction (HFpEF) is heterogenous and overlaps with that of several comorbidities like atrial fibrillation, diabetes mellitus, chronic kidney disease, valvular heart disease, iron deficiency, or sarcopenia. The diagnosis of HFpEF involves evaluating cardiac dysfunction through imaging techniques and assessing increased left ventricular filling pressure, which can be measured directly or estimated through various proxies including natriuretic peptides. To better narrow down the differential diagnosis of HFpEF, European and American heart failure guidelines advocate the use of different algorithms including comorbidities that require diagnosis and rigorous treatment during the evaluation process. Therapeutic recommendations differ between guidelines. Whilst sodium glucose transporter 2 inhibitors have a solid evidence base, the recommendations differ with regard to the use of inhibitors of the renin–angiotensin–aldosterone axis. Unless indicated for specific comorbidities, the use of beta-blockers should be discouraged in HFpEF. The aim of this article is to provide an overview of the current state of the art in HFpEF diagnosis, clinical evaluation, and treatment.
Graphical Abstract
Symptomatic corpus luteum hemorrhage in adolescent females with ITP
Authors: Yelak Alexander , From Anat , Gilad Oded , Brik Simon Dafna , Rubin Shiri , Cohen Miriam , Amarilyo Gil , Levin Carina , Bakry Doua , Izraeli Shai , Tamary Hannah , Yacobovich Joanne , Steinberg-Shemer Orna 
Published: April 2024

AbstractPatients with immune thrombocytopenia (ITP) usually present with minor mucocutaneous bleeding. Corpus luteum hemorrhage (CLH) is generally asymptomatic but may, rarely, lead to severe intraperitoneal bleeding, mostly in patients with coagulation disorders. CLH causing intraperitoneal bleeding has only been described in few individuals with ITP. The objective of this retrospective observational study was to assess the clinical course and incidence of symptomatic CLH in adolescent females with newly diagnosed or chronic ITP. Additionally, a comprehensive literature review was conducted to scrutinize cases of pediatric female patients with ITP, complicated by CLH. We identified three patients with ITP and hemoperitoneum secondary to CLH. They presented with acute abdominal pain, had severe thrombocytopenia (platelet counts below 20 × 109/L), and required blood transfusions as well as ITP-directed therapy. All the patients were hemodynamically stable and did not require emergency surgical intervention. Conclusion: CLH could potentially pose a significant complication in the context of adolescent females with ITP, requiring a strong index of suspicion to direct expedient therapy.

What is Known:• Immune thrombocytopenia is typically associated with minor bleeding tendency.• Corpus luteum hemorrhage is generally asymptomatic; however, in women with bleeding disorders, it has the potential to result in substantial intra-abdominal bleeding.

What is New:• Corpus luteum hemorrhage leading to intra-abdominal bleeding is a potential severe complication of immune thrombocytopenia in adolescent females.
Prognostic and onco-immunological value of immune-related eRNAs-driven genes in lung adenocarcinoma
Authors: Wu Xuan , Zhao Xingru , Zhou Chao , Wei Nan , Xu Zhiwei , Zhang Xiaoju 
Published: April 2024

Abstract
Background
We aimed to comprehensively analyze the clinical value of immune-related eRNAs-driven genes in lung adenocarcinoma (LUAD) and find the potential biomarkers for prognosis and therapeutic response to improve the survival of this malignant disease.

Materials and methods
Pearson’s correlation analysis was performed to identify the immune-related eRNAs-driven genes. Cox regression and least absolute shrinkage and selection operator (LASSO) analyses were used to construct this prognostic risk signature. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were used to investigate the underlying molecular mechanism. The single sample gene set enrichment analysis (ssGSEA) algorithm was conducted to evaluate the immune status based on the signature. The quantitative real-time PCR (qRT-PCR) analysis was performed to evaluate the expression value of the signature genes between LUAD tissues and adjacent lung tissues.

Results
Five immune-related eRNAs-driven genes (SHC1, GDF10, CCL14, FYN, and NOD1) were identified to construct a prognostic risk signature with favorable predictive capacity. The patients with high-risk scores based on the signature were significantly associated with the malignant clinical features compared with those with low-risk scores. Kaplan–Meier analysis demonstrated that the sample in the low-risk group had a prolonged survival compared with those in the high-risk group. This risk signature was validated to have a promising predictive capacity and reliability in diverse clinical situations and independent cohorts. The functional enrichment analysis demonstrated that humoral immune response and intestinal immune network for IgA production pathway might be the underlying molecular mechanism related to the signature. The proportion of the vast majority of immune infiltrating cells in the high-risk group was significantly lower than that in the low-risk group, and the immunotherapy response rate in the low-risk group was significantly higher than that in the high-risk group. Moreover, BI-2536, sepantronium bromide, and ULK1 were the potential drugs for the treatment of patients with higher risk scores. Finally, the experiment in vivo and database analysis indicated that CCL14, FYN, NOD1, and GDF10 are the potential LUAD suppressor and SHC1 is a potential treatment target for LUAD.

Conclusion
Above all, we constructed a prognostic risk signature with favorable predictive capacity in LUAD, which was significantly associated with malignant features, immunosuppressive tumor microenvironment, and immunotherapy response and may provide clinical benefit in clinical decisions.
Oral arsenic plus imatinib versus imatinib solely for newly diagnosed chronic myeloid leukemia: a randomized phase 3 trial with 5-year outcomes
Authors: Tian Jie , Song Yong-Ping , Zhang Gao-Chong , Wang Shu-Fang , Chu Xiao-Xiang , Chai Ye , Wang Chun-Ling , He Ai-Li , Zhang Feng , Shen Xu-Liang , Zhang Wei-Hua , Yang Lin-Hua , Nie Da-Nian , Wang Dong-Mei , Zhu Huan-Ling , Gao Da , Lou Shi-Feng , Zhou Ze-Ping , Su Guo-Hong , Li Yan , Lin Jin-Ying , Shi Qing-Zhi , Ouyang Gui-Fang , Jing Hong-Mei , Chen Sai-Juan , Li Jian , Mi Jian-Qing 
Published: April 2024

Abstract
Purpose
The synergistic effects of combining arsenic compounds with imatinib against chronic myeloid leukemia (CML) have been established using in vitro data. We conducted a clinical trial to compare the efficacy of the arsenic realgar–indigo naturalis formula (RIF) plus imatinib with that of imatinib monotherapy in patients with newly diagnosed chronic phase CML (CP-CML).

Methods
In this multicenter, randomized, double-blind, phase 3 trial, 191 outpatients with newly diagnosed CP-CML were randomly assigned to receive oral RIF plus imatinib (n = 96) or placebo plus imatinib (n = 95). The primary end point was the major molecular response (MMR) at 6 months. Secondary end points include molecular response 4 (MR4), molecular response 4.5 (MR4.5), progression-free survival (PFS), overall survival (OS), and adverse events.

Results
The median follow-up duration was 51 months. Due to the COVID-19 pandemic, the recruitment to this study had to be terminated early, on May 28, 2020. The rates of MMR had no significant statistical difference between combination and imatinib arms at 6 months and any other time during the trial. MR4 rates were similar in both arms. However, the 12-month cumulative rates of MR4.5 in the combination and imatinib arms were 20.8% and 10.5%, respectively (p = 0.043). In core treatment since the 2-year analysis, the frequency of MR4.5 was 55.6% in the combination arm and 38.6% in the imatinib arm (p = 0.063). PFS and OS were similar at five years. The safety profiles were similar and serious adverse events were uncommon in both groups.

Conclusion
The results of imatinib plus RIF as a first-line treatment of CP-CML compared with imatinib might be more effective for achieving a deeper molecular response (Chinadrugtrials number, CTR20170221).
A Test System for Microwave-Assisted Dual-Mode Mechanical Cutting of Hard Rock Under True Triaxial Compression
Authors: Feng Xia-Ting , Su Xiang-xin , Yang Cheng-xiang , Lin Feng , Li Shi-ping , Zhang Jiu-yu , Tong Tian-yang 
Published: April 2024

AbstractThis paper introduces a test system for microwave-assisted dual-mode mechanical cutting of hard rock under true triaxial compression. The test system was developed by Northeastern University, China, to simulate the cutting and breaking of hard rock by a tunnel boring machine (TBM). The test system is mainly composed of a dual-mode mechanical cutting subsystem, a true triaxial loading subsystem and a high-power microwave presplitting subsystem. The system performs dual-mode cutting under true triaxial stress, applies a single sensor to monitor the three-dimensional force of the cutter head, and integrates the reduction in the vibration and resistance to torsion during the cutting process. Mechanical cutting tests of basalt under different amounts of microwave irradiation and true triaxial stress conditions were conducted in Chifeng, Inner Mongolia, China. The results showed that microwave radiation presplitting effectively improved the efficiency of mechanical rock breaking. However, after 180 s of microwave irradiation, true triaxial high stress inhibited the mechanical breaking of basalt in terms of the overall excavation depth. During the tests, each system performed stably. The test results verified the reliability of the test system.
On the Microstructure and Dynamics of Membranes Formed by Lipid as From Stenotrophomonas maltophilia, a Member of Gut Microbiome: An EPR Study
Authors: Vitiello G. , Esposito R. , Speciale I. , De Castro C. , D’Errico G. 
Published: April 2024

AbstractLipid As are the main components of the external leaflet of the outer membrane of Gram-negative bacteria. Their molecular structure has evolved to allow the bacteria survival in specific environments. In the present work, we investigate how and to what extent lipid membranes that include in their composition lipid A molecules of a bacterium of the gut microbiota, Stenotrophomonas maltophilia, differ from those formed by the lipid A of the common Gram-negative bacterium Salmonella enterica, which is not specific to the gut and is here used as a reference. Electron Paramagnetic Resonance (EPR) spectroscopy, using spin-labelled lipids as molecular probes, allows the segmental order of the acyl chain and the polarity across the bilayer to be analyzed in detail. Both considered lipid As cause a stiffening of the outermost segments of the acyl chains. This effect increases with increasing the lipid A content and is stronger for the lipid A extracted from Stenotrophomonas maltophilia than for that extracted from Salmonella enterica. At the same time, the local polarity of the bilayer region just below the interface increases. As the inner core of the bilayer is considered, it is found that the lipid A from Salmonella enterica causes a local disorder and a significant reduction of the local polarity, an effect not found for the lipid A from Stenotrophomonas maltophilia. These results are interpreted in terms of the different lengths and distributions of the acyl tails in the two lipid As. It can be concluded that the symmetrically distributed short tails of the lipid A from Stenotrophomonas maltophilia favors a regular packing within the bilayer.
Deterioration of volcanic tuffs from rock dwellings in Brhlovce (Slovakia) induced by freeze-thaw cycling studied by non-destructive tests and µCT visualization
Authors: Maľa M. , Greif V. , Ondrášik M. 
Published: April 2024

AbstractThe aim of this paper is to evaluate the effect of freeze-thaw-induced weathering of volcanic tuffs from the rock dwellings in the village of Brhlovce (Slovakia) based on a non-destructive and experimental study of tuff pore space properties. Traditional techniques for characterization of the porosity and pore size distribution and new experimental techniques like spontaneous imbibition (pore interconnection) or indicative rock pore structure method (pore size distribution) were compared with pore network models acquired by X-ray computed microtomography before and after freeze-thaw cycling in a custom-built thermodilatometer VLAP04. The results offer insight into how frost weathering altered the pore network of volcanic tuffs. Brhlovce tuffs are highly susceptible to frost damage due to their high porosity, pore interconnectivity, and bimodal pore size distribution pattern, where nanometric-sized micropores predominate over larger micrometric-sized capillary pores. Poromechanical principles were applied to confirm that ice crystallization initiates in well-connected micropores with a corresponding crystallization pressure below 10 MPa. After undergoing 100 freeze-thaw cycles with temperature oscillations ranging from − 10 to 10 °C, there was a significant increase in total porosity, pore interconnectivity, and rock permeability. Additionally, the pore size distribution was altered. These parameters influence the transport of fluids and the moisture regime in rock masses, which can serve as a precursor to physical and chemical weathering processes
Spectroscopic evaluation of sesame and mustard oils treated with Murchana method
Authors: Deekshitha S , Neelavara Makkithaya Kausalya , Sajankila Nadumane Sharmila , Hussain Gazala , Sankar Mal Sib , Sundara Babitha K. , Pai Padmini , Mazumder Nirmal 
Published: April 2024

Abstract
In recent years, there has been a growing interest in traditional medicinal practices such as Ayurveda, which emphasizes the use of natural ingredients for various therapeutic purposes. Vegetable oils are an integral part of our diet and have several applications in the cosmetics and healthcare industries. These oils have also been prescribed in ancient Ayurveda texts to treat various health problems. Ayurveda prescribes a processing technique called ‘Murchana’ to improve the therapeutic nature of the oils. Spectroscopic techniques have been used for quality assessment in many fields. High sensitivity and a low detection rate make spectroscopy a formidable analytical technique. This study focusses on the spectroscopic analysis of sesame and mustard oils prepared using the ayurvedic processing method ‘Murchana’. Spectroscopic analysis techniques including UV-Vis absorbance spectroscopy, fluorescence spectroscopy, and FTIR spectroscopy were employed to study the oils. Origin software was used to plot graphs of the spectra. The results indicated that the murchana process may reduce the components of the oil responsible for its oxidation, thereby increasing the shelf life of the oils. However, further investigations, including other spectroscopy and chromatography techniques, will prove beneficial in ascertaining the effects of the murchana process on vegetable oils. The study’s findings also suggest that spectroscopic techniques can be used to supplement chemical techniques to investigate the characteristics of vegetable oils.
Modelling the impact of climate change on cultural practices: the future of fen skating (1981–2079)
Authors: Richards Jenny 
Published: April 2024

AbstractCultural practices reliant on the formation of ice are likely to be affected by climate change across the world. Outdoor skating is a popular pastime in many regions of North America, Asia and northern Europe. Fen skating is a traditional sport practiced in the flat area of east England, when shallowly flooded fields and meadows freeze to form large stretches of ice. To assess the future of fen skating, climate metrics were constructed to capture the freezing conditions needed for fen skating to take place. A skating freeze was defined as requiring the daily minimum temperature to be either (i) four nights below -4 °C, (ii) three nights below -5 °C or (iii) two nights below -8 °C. The 12 km resolution UKCP18 dataset was used to assess the frequency and duration of skating freezes in the fens for the period 1981 to 2079. Results from the 12 UKCP18 model members showed notable variability and only four model members successfully captured past skating freezes. Outputs from these four model members showed a rapid decrease in the frequency and duration of skating freezes, raising concerns over the future of this sport.
Bridging the gap: robotic applications in cerebral aneurysms neurointerventions - a systematic review
Authors: Łajczak Paweł Marek , Jurek Bartłomiej , Jóźwik Kamil , Nawrat Zbigniew 
Published: April 2024

AbstractCerebral aneurysm is a life-threatening condition, which requires high precision during the neurosurgical procedures. Increasing progress of evaluating modern devices in medicine have led to common usage of robotic systems in many fields, including cranial aneurysm operations. However, currently no systematic review describes up-to date knowledge of this topic. Following PRISMA guidelines, we have independently screened and extracted works from seven databases. Only studies fulfilling inclusion criteria were presented in this study. Device used, operation time, complications, aneurysm type and patient demographics were extracted from each work. We identified a total of 995 articles from databases. We have found six original works and one supplementary article eligible for this synthesis. Majority of works (4/6) have implemented CorPath GRX in cerebral aneurysm procedures. The procedures involved diverse aneurysm locations, utilizing flow diverters, stents, or coiling. One study described implementation of robot-assist on 117 patients and compared results to randomized clinical trials. One work with a small patient cohort described use of the magnetically-controlled microguidewire in the coiling procedures, without any complications. Additionally, one case-series study described use of a robotic arm for managing intraoperative aneurysm rupture. Currently, robotical devices for cerebral aneurysm treatment mainly lack jailing and haptic feedback feature. Further development of these devices will certainly be beneficial for operators and patients, allowing for more precise and remote surgeries.
Structured barycentric forms for interpolation-based data-driven reduced modeling of second-order systems
Authors: Gosea Ion Victor , Gugercin Serkan , Werner Steffen W. R. 
Published: April 2024

AbstractAn essential tool in data-driven modeling of dynamical systems from frequency response measurements is the barycentric form of the underlying rational transfer function. In this work, we propose structured barycentric forms for modeling dynamical systems with second-order time derivatives using their frequency domain input-output data. By imposing a set of interpolation conditions, the systems’ transfer functions are rewritten in different barycentric forms using different parametrizations. Loewner-like algorithms are developed for the explicit computation of second-order systems from data based on the developed barycentric forms. Numerical experiments show the performance of these new structured data-driven modeling methods compared to other interpolation-based data-driven modeling techniques from the literature.