bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing Doppler Ultrasonography and Computerized Tomography Angiography in Emergency Department Evaluation of Earthquake-Related Crush Injuries: A Case Series Analysis
Authors: Cetinkaya Remzi , Ozel Mehmet , Tatliparmak Ali Cankut , Yılmaz Sarper , Ak Rohat 
Published: February 2024

AbstractObjective:This case series aims to provide a comprehensive description of the utilization of doppler ultrasonography (USG) and computerized tomography angiography (CTA) in evaluating patients with earthquake-induced crush injuries in the emergency department (ED).Methods:This retrospective case series was conducted on 11 patients who presented with crush injuries following a seismic event. These patients underwent initial assessment using doppler USG, with CTA performed when deemed necessary. Clinical outcomes and diagnostic findings were systematically reviewed.Results:A cohort of 11 earthquake-related crush injury patients (six females, five males; age 3-59 years), predominantly with lower extremity injuries, with entrapped durations that ranged from 12 to 128 hours. Transport centers received patients from both affected regions and nearby provinces. Initial X-rays identified fractures in two cases. Doppler USG and subsequent CTA were employed for vascular evaluation, with CTA confirming doppler USG findings. Of the 11 patients, five exhibited abnormal doppler USG findings. Four patients required dialysis and four underwent amputation surgery. Fasciotomy and debridement procedures were performed in five and seven patients, respectively. Three patients received hyperbaric oxygen therapy (HBOT).Conclusion:Doppler USG emerged as a dependable tool for assessing vascular injuries in earthquake-related crush injuries, offering an effective alternative to CTA without the associated contrast agent risks. These findings underscore the need for further research to establish definitive imaging guidelines in these challenging clinical scenarios.
Comparative Analysis of META and SALT Disaster Triage in an Adult Trauma Population: A Retrospective Observational Study
Authors: Tiyawat Gawin , Liu J. Marc , Huabbangyang Thongpitak , Roza-Alonso Cesar Luis , Castro-Delgado Rafael 
Published: February 2024

AbstractBackground:Medical professionals can use mass-casualty triage systems to assist them in prioritizing patients from mass-casualty incidents (MCIs). Correct triaging of victims will increase their chances of survival. Determining the triage system that has the best performance has proven to be a difficult question to answer. The Advanced Prehospital Triage Model (Modelo Extrahospitalario de Triaje Avanzado; META) and Sort, Assess, Lifesaving Interventions, Treatment/Transport (SALT) algorithms are the most recent triage techniques to be published. The present study aimed to evaluate the META and SALT algorithms’ performance and statistical agreement with various standards. The secondary objective was to determine whether these two MCI triage systems predicted patient outcomes, such as mortality, length-of-stay, and intensive care unit (ICU) admission.Methods:This retrospective study used patient data from the trauma registry of an American College of Surgeons Level 1 trauma center, from January 1, 2018 through December 31, 2020. The sensitivity, specificity, and statistical agreement of the META and SALT triage systems to various standards (Revised Trauma Score [RTS]/Sort Triage, Injury Severity Score [ISS], and Lerner criteria) when applied using trauma patients. Statistical analysis was used to assess the relationship between each triage category and the secondary outcomes.Results:A total of 3,097 cases were included in the study. Using Sort triage as the standard, SALT and META showed much higher sensitivity and specificity in the Immediate category than for Delayed (Immediate sensitivity META 91.5%, SALT 94.9%; specificity 60.8%, 72.7% versus Delayed sensitivity 28.9%, 1.3%; specificity 42.4%, 28.9%). With the Lerner criteria, in the Immediate category, META had higher sensitivity (77.1%, SALT 68.6%) but lower specificity (61.1%) than SALT (71.8%). For the Delayed category, SALT showed higher sensitivity (META 61.4%, SALT 72.2%), but lower specificity (META 75.1%, SALT 67.2%). Both systems showed a positive, though modest, correlation with ISS. For SALT and META, triaged Immediate patients tended to have higher mortality and longer ICU and hospital lengths-of-stay.Conclusion:Both META and SALT triage appear to be more accurate with Immediate category patients, as opposed to Delayed category patients. With both systems, patients triaged as Immediate have higher mortality and longer lengths-of-stay when compared to Delayed patients. Further research can help refine MCI triage systems and improve accuracy.
Food insecurity and disability among working-age and older adults
Authors: Hadfield-Spoor Mia , Avendano Mauricio , Loopstra Rachel 
Published: February 2024

Abstract

Objective:
To explore relationships between disability, food insecurity (FI) and age and examine how socio-economic factors impact risk of FI among disabled people in working and older age.

Design:
Logistic regression models used to analyse the contribution of socio-economic factors to gaps in risk of FI for disabled people. In models stratified into working and older age groups, differences in risk of FI for disabled and non-disabled people were examined by employment, education and assets.

Setting:
England, Wales and Northern Ireland, 2016 and 2018

Participants:
A representative sample of 6187 adults aged 16+, of whom 28 % were disabled, from the Food & You survey.

Results:
The gap in FI risk by disability status decreased as age increased. For ages 25–34 for disabled v. non-disabled people, risk of FI was 31 % (95 % CI 21–41 %) v. 10 % (8–12 %); at ages 45 to 54, it was 18 % (11–23 %) v. 7 % (5–8 %), and at ages 75+, there was no gap in risk. Accounting for socio-economic variables halved the gap in risk among working ages. However, among working-age adults, FI among disabled people in full-time work was 15 % (11–20 %) compared with only 7 % (6–9 %) among non-disabled people in full-time work. Among older people, disabled people without savings were at higher risk of FI (5 % (3–7 %)) than non-disabled people without savings (2 % (1–3 %)) but having savings closed risk gap.

Conclusions:
Socio-economic resources partially explain disparities in FI risk when disabled. Disparities remained for people in full-time work and among people without savings in older age.
Evidence of validity and accuracy for the Mindful Self-Care Scale-Brief among family caregivers of people with cancer in Brazil: A cross-sectional study
Authors: Garcia Ana Cláudia Mesquita , Silva Cremilson de Paula , Paiva Eliza Mara das Chagas , Meireles Everson , Nogueira Denismar Alves , Wong Claudia 
Published: February 2024

AbstractObjectivesThis study aimed to evaluate the evidence of validity and accuracy for the Mindful Self-Care Scale-Brief (B-MSCS) in Brazil among family caregivers of people with cancer.MethodsThis was a cross-sectional study with a sample of 203 family caregivers of people with cancer. The instruments used in this study were the following: B-MSCS, Brief Resilience Scale, and Brief Scale for Spiritual/Religious Coping. Exploratory factor analysis was carried out using the principal axis factoring method and direct oblimin oblique rotation, and confirmatory factor analysis using the robust weighted least squares means and variance adjusted estimation method and GEOMIM oblique rotation. The internal consistency of the latent factors was measured using Cronbach’s alpha coefficients.ResultsThe 6-factor model showed good fit to the data, with satisfactory reliability indices and adequate representation of the scale’s internal structure. The results that can support arguments in favor of validity evidence based on internal structure for the B-MSCS-Brazilian version (BR) relate to a 19-item version which, grouped into 6 latent factors, explained 46.47% of the variance. The factor solution reproduced 79.2% of the theoretically expected structure and 5 items were excluded. The Cronbach’s alpha coefficient of the factors in the B-MSCS-BR ranged from 0.58 to 0.84. Positive religious/spiritual coping had a direct association with the B-MSCS-BR factors, with the exception of the Physical Care factor (r = 0.033, p = 0.635). Negative spiritual/religious coping was inversely associated with the Mindful Relaxation (r = −0.160, p = 0.023), Supportive Relationships (r = −0.142, p = 0.043), and Mindful Awareness factors (r = −0.140, p = 0.045). There were no associations between the B-MSCS-BR factors and resilience.Significance of resultsThe findings reveal that the B-MSCS (19-item) is a valid, reliable, and culturally-appropriate instrument to examine the practice of mindful self-care by family caregivers of people with cancer in Brazil.
Impacts of Local Green's Functions on Modeling Atmospheric Loading Effects for GNSS Reference Stations
Authors: Fan Wenlan , Jiang Weiping , Li Zhao , Tao Jun , Wang Ze , He Linyu 
Published: February 2024

AbstractThe Green's function approach is well‐established and widely used for modeling the surface mass loading displacements. Global mean Green's functions (MGFs) are commonly applied without considering local variations of the crustal structure. Derived from the modified layered Earth structure, the local Green's functions (LGFs) are theoretically beneficial to generate more accurate deformation, since they consider interior information of the local crust. This paper analyzed the differences among MGFs from Gutenberg–Bullen A model and two sets of LGFs derived from modified PREM Earth models consolidating with two crust models TEA12 and CRUST1.0, hereafter called PREMTEA and PREMCRU, respectively. Utilizing MGFs and two sets of LGFs, we modeled the corresponding 3D atmospheric loading displacements for 984 ITRF2014 stations and compared them with the ITRF2014 residuals. The results show that LGFs from PREMTEA and PREMCRU perform well in further promoting scatter reduction for ∼72%, ∼56%, and ∼85% of stations for the Up, East and North components, respectively. The improvements for the North components are significant (up to 3.6%). In particular, stations in the east coastal areas of North America and the west edge of Greenland exhibit further promoting scatter reduction for the East components (up to ∼2.5%), while those located in west coastline of North America show better performance for the North components. Nevertheless, there are significant anomalies in northern Europe for PREMCRU, the mutation margin of which should be carefully considered when using a resolution higher than 1°. In the area around station MORP (358.31°W, 55.21°N, sited at coastline of Britain), we suggest using PREMTEA model.
On the Spatial and Temporal Evolution of EMIC Wave‐Driven Relativistic Electron Precipitation: Magnetically Conjugate Observations From the Van Allen Probes and CALET
Authors: Blum L. W. , Bruno A. , Capannolo L. , Ma Q. , Kataoka R. , Torii S. , Baishev D. 
Published: February 2024

AbstractElectromagnetic ion cyclotron (EMIC) waves have been shown to be able to drive strong electron precipitation, particularly at MeV energies. However, the spatio‐temporal evolution of both the waves and the resulting precipitation is still not well understood. Here we investigate the evolution of relativistic electron precipitation driven by EMIC waves through combined observations from the Van Allen Probes and the CALorimetric Electron Telescope experiment onboard the International Space Station. Two case studies are examined where EMIC waves near the magnetic equator and precipitation at low altitude were detected in close magnetic conjunction, both of which were confined to narrow radial regions but persisted multiple hours. These observations, combined with quasilinear calculations, confirm that long‐lived EMIC waves can drive hours‐long MeV electron precipitation loss. However, the magnitude of the precipitation varied significantly during one of the events, as resonance conditions, particularly plasma density, evolved.
Mantle Structure Beneath the Damara Belt in South‐Central Africa Imaged Using Adaptively Parameterized P‐Wave Tomography
Authors: Saeidi Hesam , Hansen Samantha E. , Nyblade Andrew A. , Haag Ryan 
Published: February 2024

AbstractMany seismic tomography studies have indicated that the African Large Low Velocity Province (LLVP) extends from the lower mantle beneath southern Africa into the upper mantle beneath eastern Africa; however, it has been questioned whether the LLVP structure may also extend to the north or northwest beneath south‐central Africa. Debates regarding the upper mantle structure beneath the Damara Belt contribute to this uncertainty. Some studies suggest the Damara Belt is underlain by thermally perturbed upper mantle; however, other studies indicate the region is not associated with anomalous structure. Here, we use a comprehensive P‐wave travel‐time data set and an adaptive model parameterization to develop a new tomographic model for the Damara Belt and surrounding regions. Our results show that seismically slow structure beneath the Damara Belt is relegated to depths greater than ∼1,200 km, indicating that the LLVP is not significantly affecting this region. However, further to the northeast, the LLVP structure obliquely rises and crosses the mantle transition zone near the Irumide Belt, where it then extends into the upper mantle. The seismic structure beneath the Damara Belt and neighboring areas in our model correlates well with tectonic observations at the surface, including variations in heat flow, the distribution of geothermal features, the locations of rifts, and estimates of dynamic topography.
System‐Wide Effects of Local Bed Disturbance on the Morphological Evolution of a Bifurcating Channel Network
Authors: Gao Weilun , Shao Dongdong , Wang Zheng Bing , Zhu Zhenchang , Yang Zhifeng 
Published: February 2024

AbstractDeltaic channel networks are important conduits for water and material supplies to the fluvial and coastal communities. However, increasing human interventions in river deltas have altered the topology and geometry of channel networks as well as their long‐term evolution. While the morphological evolution of a single channel has received extensive studies, the system‐wide morphological responses of channel networks to local disturbances remain largely unclear. Here we investigate the morphological responses of a bifurcating channel network subject to local disturbance of channel deepening due to dredging and sand mining through idealized simulations, and further compare the results with the reference scenarios of a single channel and theoretical analysis of the phase plane. The results show that the infilling of the local deepening is associated with the erosion of the entire branch, which also causes system‐wide effects on the siltation of the other branch. The morphological responses of the bifurcating channel network consist of a relatively short stage for the infilling of the local deepening followed by a relatively long stage for recovering the equilibrium configuration of the river bifurcation. The system‐wide effects of the local disturbance arise from the altered water surface slope and water partitioning downstream of the bifurcation due to the local deepening. Also, the prolonged recovery of the equilibrium configuration is consistent with theoretical analysis, which reveals a slow evolution of the bifurcation when approaching the equilibrium. Our results can help understand the long‐term morphological responses of large‐scale complex channel networks and inform water managements under increasing human interventions.
Road Salt Legacies: Quantifying Fluxes of Chloride to Groundwater and Surface Water Across the Chicago Metropolitan Statistical Area
Authors: Van Meter K. J. , Ceisel E. 
Published: February 2024

AbstractFreshwater chloride concentrations have been increasing in North American surface waters for decades, largely driven by increases in the use of road salt, which is commonly applied as a deicer. In Chicago, thousands of tons of road salt are applied to roadways each winter, and increases in surface water chloride concentrations have been noted across the region since the mid‐1960s. While much of the applied salt runs directly off to nearby waterways during snowmelt events, some percolates to groundwater, affecting public supply wells and increasing the amount of chloride released to streams as baseflow during the non‐salting season. In the present study we have developed a spatially distributed chloride mass balance across the Chicago Metropolitan Statistical Area (CMSA) for a 30‐year period (1990–2020) to better our understanding of long‐term chloride fluxes and storage. Our results show that inputs of road salt to the region increased by 33% between 1990 and 2020. During this same period, riverine chloride loads across the region increased by 60%. Despite these increases in riverine chloride export, we find that chloride is accumulating in CMSA groundwater at a rate of ∼480 ktons year−1. We show that shallow aquifers, <30 m, exhibit only seasonal chloride storage, without long‐term accumulation. In contrast, at depths below 30 m, we find chloride concentrations to be increasing over time, indicating that legacy chloride is accumulating at deeper depths in CMSA groundwater. The present results highlight the importance of legacy chloride to long‐term water quality dynamics in North American cities.
The c.1617del variant of TMEM260 is identified as the most frequent single gene determinant for Japanese patients with a specific type of congenital heart disease
Authors: Inoue Tadashi , Takase Ryuta , Uchida Keiko , Kodo Kazuki , Suda Kenji , Watanabe Yoriko , Yoshiura Koh-Ichiro , Kunimatsu Masaya , Ishizaki Reina , Azuma Kenko , Inai Kei , Muneuchi Jun , Furutani Yoshiyuki , Akagawa Hiroyuki , Yamagishi Hiroyuki 
Published: February 2024

AbstractAlthough the molecular mechanisms underlying congenital heart disease (CHD) remain poorly understood, recent advances in genetic analysis have facilitated the exploration of causative genes for CHD. We reported that the pathogenic variant c.1617del of TMEM260, which encodes a transmembrane protein, is highly associated with CHD, specifically persistent truncus arteriosus (PTA), the most severe cardiac outflow tract (OFT) defect. Using whole-exome sequencing, the c.1617del variant was identified in two siblings with PTA in a Japanese family and in three of the 26 DNAs obtained from Japanese individuals with PTA. The c.1617del of TMEM260 has been found only in East Asians, especially Japanese and Korean populations, and the frequency of this variant in PTA is estimated to be next to that of the 22q11.2 deletion, the most well-known genetic cause of PTA. Phenotype of patients with c.1617del appears to be predominantly in the heart, although TMEM260 is responsible for structural heart defects and renal anomalies syndrome (SHDRA). The mouse TMEM260 variant (p.W535Cfs*56), synonymous with the human variant (p.W539Cfs*9), exhibited truncation and downregulation by western blotting, and aggregation by immunocytochemistry. In situ hybridization demonstrated that Tmem260 is expressed ubiquitously during embryogenesis, including in the development of cardiac OFT implicated in PTA. This expression may be regulated by a ~ 0.8 kb genomic region in intron 3 of Tmem260 that includes multiple highly conserved binding sites for essential cardiac transcription factors, thus revealing that the c.1617del variant of TMEM260 is the major single-gene variant responsible for PTA in the Japanese population.
Stromal thrombospondin 1 suppresses angiogenesis in oral submucous fibrosis
Authors: Yang Xiao , Zhao Hui , Li Rui , Chen Yang , Xu Zhi , Shang Zhengjun 
Published: February 2024

AbstractA decline in mucosal vascularity is a histological hallmark of oral submucous fibrosis (OSF), a premalignant disease that is largely induced by betel quid chewing. However, the lack of available models has challenged studies of angiogenesis in OSF. Here, we found that the expression of thrombospondin 1 (THBS1), an endogenous angiostatic protein, was elevated in the stroma of tissues with OSF. Using a fibroblast-attached organoid (FAO) model, the overexpression of THBS1 in OSF was stably recapitulated in vitro. In the FAO model, treatment with arecoline, a major pathogenic component in areca nuts, enhanced the secretion of transforming growth factor (TGF)-β1 by epithelial cells, which then promoted the expression of THBS1 in fibroblasts. Furthermore, human umbilical vein endothelial cells (HUVECs) were incorporated into the FAO to mimic the vascularized component. Overexpression of THBS1 in fibroblasts drastically suppressed the sprouting ability of endothelial cells in vascularized FAOs (vFAOs). Consistently, treatment with arecoline reduced the expression of CD31 in vFAOs, and this effect was attenuated when the endothelial cells were preincubated with neutralizing antibody of CD36, a receptor of THBS1. Finally, in an arecoline-induced rat OSF model, THBS1 inhibition alleviated collagen deposition and the decline in vascularity in vivo. Overall, we exploited an assembled organoid model to study OSF pathogenesis and provide a rationale for targeting THBS1.
Mediating effect of fat mass, lean mass, blood pressure and insulin resistance on the associations of accelerometer-based sedentary time and physical activity with arterial stiffness, carotid IMT and carotid elasticity in 1574 adolescents
Authors: Agbaje Andrew O. 
Published: February 2024

AbstractThis study examined the mediating effect of total body fat mass, lean mass, blood pressure (BP) and insulin resistance on the associations of sedentary time (ST), light physical activity (LPA) and moderate-to-vigorous PA (MVPA) with carotid-femoral pulse wave velocity (cfPWV), carotid intima-media thickness (cIMT) and carotid elasticity in 1574 adolescents from the Avon Longitudinal Study of Parents and Children birth cohort, UK. ST, LPA and MVPA were assessed with ActiGraph accelerometer. ST and LPA were sex-categorised in tertiles as low (reference), moderate and high, while MVPA was categorised as <40 min/day (reference), 40–<60 min/day and ≥60 min/day. cfPWV, cIMT and carotid elasticity were measured with Vicorder and ultrasound. Fat mass and lean mass were assessed with dual-energy X-ray absorptiometry and homeostatic model assessment of insulin resistance (HOMA-IR) was computed. Mediation analyses structural equation models and linear mixed-effect models adjusted for cardiometabolic and lifestyle factors were conducted. Among 1574 adolescents [56.2% female; mean (SD) age 15.4 (0.24) years], 41% males and 17% females accumulated ≥60 min/day of MVPA. Higher ST was associated with lower cIMT partly mediated by lean mass. Higher LPA (standardized β = −0.057; [95% CI −0.101 to −0.013; p = 0.014]) and the highest LPA tertile were associated with lower cfPWV. BP had no significant mediating effect movement behaviour relations with vascular indices. Lean mass partially mediated associations of higher MVPA with higher cIMT (0.012; [0.007–0.002; p = 0.001], 25.5% mediation) and higher carotid elasticity (0.025; [0.014–0.039; p = 0.001], 28.1% mediation). HOMA-IR mediated the associations of higher MVPA with higher carotid elasticity (7.7% mediation). Engaging in ≥60 min/day of MVPA was associated with higher carotid elasticity. In conclusion, higher LPA was associated with lower arterial stiffness, but higher MVPA was associated with thicker carotid wall explained by higher lean mass.