bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Critical Properties of Binary Mixtures Containing Carbon Dioxide: Krichevskii Parameter and Related Thermodynamic Properties
Authors: Abdulagatov A. I. , Stepanov G. V. , Abdulagatov I. M. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Linear and Cyclic Vinylogous TTF: Molecular Movement Induced by Electron Transfer
Authors: Guerro M. , Carlier R. , Lorcy D. , Hapiot P. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Protein Complexes in the Gas Phase: Technology for Structural Genomics and Proteomics
Authors: Benesch Justin L. P. , Ruotolo Brandon T. , Simmons Douglas A. , Robinson Carol V. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Multidimensional Separations‐Based Shotgun Proteomics
Authors: Fournier Marjorie L. , Gilmore Joshua M. , Martin‐Brown Skylar A. , Washburn Michael P. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cannabis, Pain, and Sleep: Lessons from Therapeutic Clinical Trials of Sativex®, a Cannabis‐Based Medicine
Authors: Russo Ethan B. , Guy Geoffrey W. , Robson Philip J. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Biosynthetic Pathways of the Endocannabinoid Anandamide
Authors: Okamoto Yasuo , Wang Jun , Morishita Jun , Ueda Natsuo 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Monoglyceride Lipase as an Enzyme Hydrolyzing 2‐Arachidonoylglycerol
Authors: Saario Susanna M. , Laitinen Jarmo T. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The N‐Acylethanolamine‐Hydrolyzing Acid Amidase (NAAA)
Authors: Tsuboi Kazuhito , Takezaki Naoko , Ueda Natsuo 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Anticancer Properties of Anthraquinones from Rhubarb
Authors: Huang Qing , Lu Guodong , Shen Han‐Ming , Chung Maxey C. M. , Ong Choon Nam 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cationic Liposomes as Non‐Viral Carriers of Gene Medicines: Resolved Issues, Open Questions, and Future Promises
Authors: Karmali Priya Prakash , Chaudhuri Arabinda 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Prevention of Nausea and Vomiting: Aprepitant, the First Therapeutically Active NK1 Receptor Antagonist
Authors: Nieber Karen , Schoppmeyer Konrad 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Microcellular Polymers and Composites. Part 1. Types of Foaming Agents and Technologies of Microcellular Processing
Authors: Bledzki Andrzej , Faruk Omar , Kirschling Hendrik , Kuehn Joanna , Jaszkiewicz Adam 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Using Fluorinated Amino Acids for Structure Analysis of Membrane‐Active Peptides by Solid‐State 19F‐NMR
Authors: Wadhwani Parvesh , Tremouilhac Pierre , Strandberg Erik , Afonin Sergii , Grage Stephan , Ieronimo Marco , Berditsch Marina , Ulrich Anne S. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cyclophosphamide plus dexamethasone is an efficient initial treatment before high‐dose melphalan and autologous stem cell transplantation in patients with newly diagnosed multiple myeloma
Authors: Mellqvist Ulf‐Henrik , Lenhoff Stig , Johnsen Hans E. , Hjorth Martin , Holmberg Erik , Juliusson Gunnar , Tangen Jon Magnus , Westin Jan 
Published: October 2007

AbstractBACKGROUNDToday, intensive therapy that includes high‐dose melphalan with autologous stem cell transplantation (ASCT) is considered standard therapy in younger patients with newly diagnosed myeloma. When the current trial was initiated, combined vincristine, doxorubicin, and dexamethasone (VAD) was the most commonly used induction therapy before ASCT and yielded rapid major responses without interfering with stem cell harvest. However, the administration of VAD demands a central venous access, and well‐described toxicities are associated with the therapy. This randomized trial, which was initiated in 2001 by the Nordic Myeloma Study Group, was an attempt to bring a larger portion of patients to ASCT more quickly.METHODSPatients were randomized to receive either 3 cycles of VAD or 2 courses of cyclophosphamide plus dexamethasone (Cy‐Dex) (cyclophosphamide at a dose of 1000 mg/m2 on Day 1 and dexamethasone at a dose of 40 mg per day on Days 1–4 and 9–12, repeated on Day 22) as initial therapy followed by stem cell mobilization, harvest, and finally ASCT.RESULTSNo significant difference was observed in the proportion of patients undergoing ASCT (VAD [86%] vs Cy‐Dex [87%]). During the first 4 months after the initiation of therapy, the mortality rates were 5.8% for VAD and 1.9% for Cy‐Dex (P = .08). The response rates after ASCT were comparable (partial response or better: VAD: 80% vs Cy‐Dex: 81%). In both groups, the median event‐free survival was 29 months, and the overall survival rate at 3 years was 75%.CONCLUSIONSThe current results indicated that Cy‐Dex before ASCT has efficacy comparable to that of VAD. It also demonstrated that a short course of alkylator therapy using cyclophosphamide does not affect stem cell harvest or transplantation. Cancer 2008. © 2007 American Cancer Society.
Mining Taverna's semantic web of provenance
Authors: Zhao Jun , Goble Carole , Stevens Robert , Turi Daniele 
Published: October 2007

AbstractTaverna is a workflow workbench developed as part of the UK's myGrid project. Taverna's provenance model captures both internal provenance locally generated in Taverna and external provenance gathered from third‐party data providers. This model also supports overlaying secondary provenance over the primary logs and lineage. This design is motivated by the particular properties of bioinformatics data and services used in Taverna. A Semantic Web of provenance, Ouzo, is built to combine the above different provenance by means of semantic annotations. This paper shows how Ouzo can be mined by a provenance usage component, Provenance Query and Answer (ProQA). ProQA supports provenance retrievals as well as provenance abstraction, aggregation, and semantic reasoning. ProQA is implemented as a suite APIs which can be deployed as provenance services to compose system provenance workflows that analyse experiment results using the provenance records. We show how these features of Taverna's provenance support us in answering the questions from the provenance challenge workshop and a set of additional provenance queries. Copyright © 2007 John Wiley & Sons, Ltd.
Tracking provenance semantics in heterogeneous execution systems
Authors: Futrelle Joe , Myers James 
Published: October 2007

AbstractDigital artifacts result from complex, heterogeneous work processes involving content management, process execution, and curation. Accordingly, systems for tracking provenance of digital artifacts need to be able to integrate heterogeneous descriptions produced by loosely coupled or independent software components and work processes. In the approach described in this paper, two independently developed execution environments, D2K and CyberIntegrator, were instrumented by their developers to produce process and content descriptions in the form of resource description framework (RDF) statements. Using the open‐source Kowari RDF database, these heterogeneous semantic descriptions were integrated to demonstrate the general applicability of RDF databases to answering provenance‐related queries. The results suggest that the ‘open‐world’ semantic model provided by RDF, and the powerful query languages provided by RDF databases, can be extended to integrate a wide variety of heterogeneous provenance‐related information with minimal investment in new standard API's, metadata formats, and execution environments. Copyright © 2007 John Wiley & Sons, Ltd.
Guiding a self‐adjusting system through chaos
Authors: W. Hübler Alfred , C. Phelps Kirstin 
Published: October 2007

AbstractThe authors studied the parametric controls of self‐adjusting systems with numerical models. The authors investigated the situation where the target dynamics changes slowly and passes through a chaotic region. The authors found that feedback destabilizes controls if the target is chaotic. If the control is unstable, the system migrates to the closest nonchaotic target, i.e., it adapts to the edge of chaos. For weak controls, the deviation between system dynamics and target is larger, but the system dynamics is less chaotic and therefore more predictable. © 2007 Wiley Periodicals, Inc. Complexity, 2007
Translational embryology: Using embryonic principles to generate pancreatic endocrine cells from embryonic stem cells
Authors: Spence Jason R. , Wells James M. 
Published: October 2007

AbstractDiseases that affect endodermally derived organs such as the lungs, liver, and pancreas include cystic fibrosis, chronic hepatitis, and diabetes, respectively. Despite the prevalence of these diseases, cures remain elusive. While several promising transplantation‐based therapies exist for some diseases such as Type 1 diabetes, they are currently limited by the availability of donor‐derived tissues. Embryonic stem cells are a promising and renewable source of tissue for transplantation; however, directing their differentiation into specific, adult cell lineages remains a significant challenge. In this review, we will focus on one endodermally derived organ, the pancreas, and discuss how studies of embryonic pancreas development have been used as the basis for the directed, step‐wise differentiation of mouse and human embryonic stem cells into pancreatic endocrine cells that are capable of rescuing Type 1 diabetes in animal models. Developmental Dynamics 236:3218–3227, 2007. © 2007 Wiley‐Liss, Inc.
Asymmetric Induction and Configurational Stability at the Metal Centre in Half‐Sandwich (η6‐p‐Cymene)ruthenium(II) and (η5‐C5Me5)rhodium(III) Complexes Containing Chiral N‐N* Ligands with Different Rigidity and Flexibility
Authors: Saporita Maria , Bottari Giovanni , Brancatelli Giovanna , Drommi Dario , Bruno Giuseppe , Faraone Felice 
Published: October 2007

AbstractThe half‐sandwich chelate complexes [Ru(η6‐p‐cymene)(N‐N*)Cl]X (X = Cl, PF6) and [Rh(η5‐C5Me5)(N‐N*)Cl]X (X = SbF6, PF6; N‐N* = (Sa)‐1 and (Sa)‐2] have been prepared by treating the complexes [{Ru(η6‐p‐cymene)Cl2}2] and [{Rh(η5‐C5Me5)Cl2}2] with the bidentate N‐N* chiral ligands in their enantiomerically pure form. The ligands contain rigid 2‐pyridinyl or 8‐quinolinyl skeletons and the C2‐symmetric chiral framework trans‐2,5‐dimethylpyrrolidinyl or (+)‐(S)‐2,2′‐(2‐azapropane‐1,3‐diyl)‐1,1′‐binaphthalene. The chelate complexes [Ru(η6‐p‐cymene)(N‐N*)Cl]Cl and [Rh(η5‐C5Me5)(N‐N*)Cl]SbF6 [N‐N* = (Sa)‐1 and (Sa)‐2] were obtained in CH3OH or CHCl3, with 100 % diastereomeric excess, in the absolute configurations (Sa,SRu) and (Sa,RRh), respectively; the ligands (R,R)‐3 and (R,R)‐4 gave the corresponding products as pairs of diastereomers with high de. A kinetic effect is present during the formation of the ruthenium and rhodium chelate complexes. The (Sa,RRh) absolute configuration of [Rh(η5‐C5Me5)(N‐N*)Cl]PF6 [N‐N* = (Sa)‐1 and (Sa)‐2], which were obtained as a single diastereomer, was assigned by X‐ray diffraction determination of their molecular structures. The nucleophilic substitution reaction of chloride by iodide in [Ru(η6‐p‐cymene)(N‐N*)Cl]PF6 [N‐N* = (Sa)‐1 and (Sa)‐2], in methanol at 328 K, occurs with retention of configuration at the metal centre, and a possible mechanism is proposed on the basis of kinetic measurements. The results indicate a striking analogy between the isoelectronic complexes [Ru(η6‐p‐cymene)(N‐N*)Cl]PF6 and [Rh(η5‐C5Me5)(N‐N*)Cl]SbF6 containing the same N‐N* chiral ligand. A rationalisation of the results is proposed on the basis of X‐ray diffraction analysis and density functional calculations. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Coordination Polymers Constructed from [Mn(N)(CN)4]2–: Synthesis, Structures, and Magnetic Properties
Authors: Guo Jun‐Fang , Yeung Wai‐Fun , Gao Song , Lee Gene‐Hsiang , Peng Shie‐Ming , Lam Michael Hon‐Wah , Lau Tai‐Chu 
Published: October 2007

AbstractThe dimetallic complexes [{Ni(cyclen)}{Mn(N)(CN)4}·CH3OH]n (cyclen = 1,4,7,10‐tetraazacyclododecane) (1), [{Cu(cyclen)}{Mn(N)(CN)4}]n (2), and [{Mn(5,5′‐Me2salen)}2{Mn(N)(CN)4}·CH3OH]n [5,5′‐Me2salen = N,N′‐bis(5,5′‐dimethylsalicylidene)‐o‐ethylenediimine] (3) have been synthesized and structurally characterized. Compounds 1 and 2 have one‐dimensional chain structures, while compound 3 has a two‐dimensional sheet‐like network structure. Magnetic studies of 1 and 3 show that there is no significant magnetic coupling between the paramagnetic metal centers. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Click Chelators for Platinum‐Based Anticancer Drugs
Authors: Maisonial Aurélie , Serafin Patrycja , Traïkia Mounir , Debiton Eric , Théry Vincent , Aitken David J. , Lemoine Pascale , Viossat Bernard , Gautier Arnaud 
Published: October 2007

AbstractTriazoles from “click chemistry” are convenient ligands for the formation of platinum complexes bearing combined triazole–amine or triazole–carboxylate moieties. Striking differences in the chelation modes are observed between the two series. One of the triazole–amine platinum complexes exhibits selective cytotoxicity against breast cancer cells lines. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
pH‐Induced Luminescence Changes of Chromophore‐Quencher Tricarbonylpolypyridylrhenium(I) Complexes with 4‐Pyridinealdazine
Authors: Cattaneo Mauricio , Fagalde Florencia , Katz Néstor E. , Borsarelli Claudio D. , Parella Teodor 
Published: October 2007

AbstractThe new chromophore‐quencher tricarbonylrhenium(I) complexes [Re(4,4′‐X2‐bpy)(CO)3(PCA)]+, [(4,4′‐X2‐bpy)(CO)3Re(μ‐PCA)Re(CO)3(4,4′‐X2‐bpy)]2+, and [(4,4′‐X2‐bpy)(CO)3ReI(μ‐PCA)RuII(NH3)5]3+ (X = Ph or CO2Me and PCA = 4‐pyridinealdazine) have been synthesized as their PF6– salts and characterized by spectroscopic, electrochemical, and photophysical techniques. In contrast to previously reported species with X = Me or H, these complexes emit at room temperature in CH3CN. The recovery of luminescence can thus be ascribed to the change of energy levels induced by adding electron‐withdrawing substituents to the 2,2′‐bipyridine ring, since the emissive ReII(X2bpy–) excited state becomes much lower in energy than the ReII(PCA–) non‐emissive excited state. For the mononuclear and symmetric dinuclear rhenium(I) complexes with X = CO2Me, consecutive protonation of both the pyridinyl and imine N atoms of PCA in aqueous solution leads to unusual bell‐shaped curves for both the absorption and the emission intensities vs. pH because of opposite effects on the electronic delocalization of PCA. This latter property can be employed to devise novel luminescent pH sensors of the on‐off‐on type. The corresponding unsymmetrical dinuclear complexes [(4,4′‐X2‐bpy)(CO)3ReI(μ‐PCA)RuIII(NH3)5]4+ have been obtained in situ by oxidizing the [ReI,RuII] precursors in CH3CN solution. Spectral and electrochemical measurements with these complexes lead to the values of the metal‐to‐metal electronic coupling elements.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Syntheses, Crystal Structures, and Optical Properties of Metal Complexes with 4′,5′‐Diaza‐9′‐(4,5‐disubstituted‐1,3‐dithiol‐2‐ylidene)fluorene Ligands
Authors: Zhu Qin‐Yu , Lu Wen , Zhang Yong , Bian Guo‐Qing , Gu Jing , Lin Xiao‐Min , Dai Jie 
Published: October 2007

AbstractFour complexes with 4′,5′‐diaza‐9′‐[4,5‐bis(methylthio)‐1,3‐dithiol‐2‐ylidene]fluorene (L1) or 4′,5′‐diaza‐9′‐[4,5‐bis(ethylthio)‐1,3‐dithiol‐2‐ylidene]fluorene (L2) were synthesized. The complexes [Co(L1)2Cl2]·2CH3OH (1), [Cu(L2)2Cl2]·CH3OH·0.5CH2Cl2 (3), and [Cu(L2)2Br2]·CH3OH (4) adopt a trans configuration and the compound [Cd(L1)2(NO3)2] (2) is a cis structure. Short S···S, C···C, and C···S contacts were found to be important in the molecular packing. Both the solution and solid‐state electronic spectra show a redshift in the intramolecular CT bands when forming metal complexes. This intramolecular charge transition in the solid state is enhanced relative to that in solution. Their third‐order nonlinear optical properties of compounds 1–4 were studied, and the results reveal that these complexes exhibit negative γ values (about 10–30) and are self‐defocusing samples. These γ values are comparable to those of the known cluster compounds. The trans coordination of the two ligands to the metal center would be beneficial to the NLO properties. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
A Pyridine‐Stabilized Alumoxane Containing Two 1,3,2‐Diazaalumina[3]ferrocenophane Units
Authors: Wrackmeyer Bernd , Klimkina Elena V. , Milius Wolfgang 
Published: October 2007

AbstractDialuminoxane 6, in which both aluminum atoms are coordinated by pyridine and each is part of a 1,3‐bis(trimethylsilyl)‐1,3,2‐diazaalumina[3]ferrocenophane unit, was isolated as a side product accompanying the synthesis of the corresponding [3]ferrocenophane with Al–H or Al–Cl functionalities. Although attempted high‐yield syntheses of 6 failed, its structure could be established by 1H, 13C, and 29Si NMR spectroscopy in solution and by X‐ray structural analysis in the solid state. In various experiments to obtain 6, crystalline material was isolated and identified as the desired dialuminoxane either with a linear Al–O–Al (6A) or bent Al–O–Al (6B) unit. This is the first example of a structurally characterized bis(amino)dialuminoxane.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Antioxidant and antimutagenic effects of the crude foliar extract and the alkaloid brachycerine of Psychotria brachyceras
Authors: do Nascimento Naíla Cannes , Fragoso Variluska , Moura Dinara Jaqueline , e Silva Ana Catarina Romano , Fett‐Neto Arthur Germano , Saffi Jenifer 
Published: October 2007

AbstractThe monoterpene indole alkaloid brachycerine from Psychotria brachyceras has been shown to be induced by UV and to have in vitro antioxidant activity, indicating a possible protective role against the secondary effects of this radiation. In this work, we have studied the antioxidant properties of brachycerine and a crude foliar extract from P. brachyceras by using Saccharomyces cerevisiae strains proficient and deficient in antioxidant defenses. The mutagenic and antimutagenic potential of these substances were assayed in S.cerevisiae N123 strain in the presence and absence of H2O2. In addition, we tested the antioxidant capacity of brachycerine and a crude foliar extract from P. brachyceras on hydroxyl radicals (OH•) using the hypoxanthine/xanthine oxidase assay. The results show that brachycerine and the crude foliar extract of P. brachyceras have antioxidant and antimutagenic effects in yeast and probably this action is mainly due to the scavenging of OH• radicals. Environ. Mol. Mutagen., 2007. © 2007 Wiley‐Liss, Inc.
Difficulty of mode of action determination for trichloroethylene: An example of complex interactions of metabolites and other chemical exposures
Authors: Caldwell Jane C. , Keshava Nagalakshmi , Evans Marina V. 
Published: October 2007

AbstractThe mode(s) of action (MOA) of a pollutant for adverse health effects may be dependent on the mixture of metabolites resulting from exposure to a single agent and may also be affected by coexposure to pollutants that have similar targets or affected pathways. Trichloroethylene (TCE) can be an useful example for illustration of the complexity coexposure can present to elucidation of the MOA of an agent. TCE exposure has been associated with increased risk of liver and kidney cancer in both laboratory animal and epidemiologic studies. There are a number of TCE metabolites that could play a role in the induction of these effects. Coexposures of other chemicals with TCE typically occurs as a result of environmental cocontamination that include its own metabolites, such as trichloroacetic acid, dichloroacetic acid, and other pollutants with similar metabolites such as perchloroethylene. Behaviors such as alcohol consumption can also potentially modify TCE toxicity through similar MOAs. The U.S. Environmental Protection Agency (EPA)'s 2001 draft TCE risk assessment, Trichloroethylene (TCE) Health Risk Assessment: Synthesis and Characterization, concluded that it was difficult to determine which of the metabolites of TCE may be responsible for these effects, what key events in their hypothesized MOAs are involved, and the relevance of some of the hypothesized MOAs to humans. Since the publication of U.S. EPA's draft TCE assessment, several studies have been conducted to understand the effects of coexposures to TCE. They cover both pharmacodynamic and pharmacokinetic considerations. This article highlights some of the recently published scientific literature on toxicological interactions between TCE, its metabolites, and other coexposures, including solvents, haloacetates, and ethanol. These studies give insight into both the potential MOAs of TCE exposure itself and putative modulators of TCE toxicity, and illustrate the difficulties encountered in determining the MOAs and modulators of toxicity for pollutants with such complex metabolism and coexposures. Environ. Mol. Mutagen., 2007. Published 2007 Wiley‐Liss, Inc.