bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human Cell‐Derived Matrix Composite Hydrogels with Diverse Composition for Use in Vasculature‐on‐chip Models
Authors: Doherty Elizabeth L. , Krohn Grace , Warren Emily C. , Patton Alexandra , Whitworth Chloe P. , Rathod Mitesh , Biehl Andreea , Aw Wen Yih , Freytes Donald O. , Polacheck William J. 
Published: March 2024

AbstractMicrophysiological and organ‐on‐chip platforms seek to address critical gaps in human disease models and drug development that underlie poor rates of clinical success for novel interventions. While the fabrication technology and model cells used to synthesize organs‐on‐chip have advanced considerably, most platforms rely on animal‐derived or synthetic extracellular matrix as a cell substrate, limiting mimicry of human physiology and precluding use in modeling diseases in which matrix dynamics play a role in pathogenesis. Here, the development of human cell‐derived matrix (hCDM) composite hydrogels for use in 3D microphysiologic models of the vasculature is reported. hCDM composite hydrogels are derived from human donor fibroblasts and maintain a complex milieu of basement membrane, proteoglycans, and nonfibrillar matrix components. The use of hCDM composite hydrogels as 2D and 3D cell culture substrates is demonstrated, and hCDM composite hydrogels are patterned to form engineered human microvessels. Interestingly, hCDM composite hydrogels are enriched in proteins associated with vascular morphogenesis as determined by mass spectrometry, and functional analysis demonstrates proangiogenic signatures in human endothelial cells cultured in these hydrogels. In conclusion, this study suggests that human donor‐derived hCDM composite hydrogels could address technical gaps in human organs‐on‐chip development and serve as substrates to promote vascularization.
Air‐Stable Perylene Diimide Trimer Material for N‐Type Organic Electrochemical Transistors
Authors: Nguyen‐Dang Tung , Bao Si Tong , Kaiyasuan Chokchai , Li Kunyu , Chae Sangmin , Yi Ahra , Joy Syed , Harrison Kelsey , Kim Jae Young , Pallini Francesca , Beverina Luca , Graham Kenneth R. , Nuckolls Colin , Nguyen Thuc‐Quyen 
Published: March 2024

AbstractA new method is reported to make air‐stable n‐type organic mixed ionic‐electronic conductor (OMIEC) films for organic electrochemical transistors (OECTs) using a solution‐processable small molecule helical perylene diimide trimer, hPDI[3]‐C11. Alkyl side chains are attached to the conjugated core for processability and film making, which are then cleaved via thermal annealing. After the sidechains are removed, the hPDI[3] film becomes less hydrophobic, more ordered, and has a deeper lowest unoccupied molecular orbital (LUMO). These features provide improved ionic transport, greater electronic mobility, and increased stability in air and in aqueous solution. Subsequently, hPDI[3]‐H is used as the active material in OECTs and a device with a transconductance of 44 mS, volumetric capacitance of ≈250 F cm−3, µC* value of 1 F cm−1 V−1 s−1, and excellent stability (> 5 weeks) is demonstrated. As proof of their practical applications, a hPDI[3]‐H‐based OECTs as a glucose sensor and electrochemical inverter is utilized. The approach of side chain removal after film formation charts a path to a wide range of molecular semiconductors to be used as stable, mixed ionic‐electronic conductors.
Atomic‐Level Matching Metal‐Ion Organic Hybrid Interface to Enhance Energy Storage of Polymer‐Based Composite Dielectrics
Authors: Liu Xiaoxu , Chen Dongyang , Li Jialong , Zhong Shao‐Long , Feng Yu , Yue Dong , Sheng Dawei , Chen Haonan , Hao Xiaodong , Dang Zhi‐Min 
Published: March 2024

AbstractIn this work, a distinctive “metal‐ion organic hybrid interface” (MOHI) between polyimide (PI) and calcium niobate (CNO) nanosheets is designed. The metal ions in the MOHI can achieve atomic‐level matching not only with the inorganic CNO, but also with the PI chains, forming uniform and strong chemical bonds. These results are demonstrated by experiment and theory calculations. Significantly, the MOHI reduces the free volume and introduces deep traps across the filler‐matrix interfacial area, thus suppressing the electric field distortion in PI‐based composite dielectrics. Consequently, PI‐based dielectric containing the MOHI exhibits excellent energy storage performance. The energy storage densities (Ue) of the composite dielectric reach 9.42 J cm−3 and 4.75 J cm−3 with energy storage efficiency (η) of 90% at 25 °C and 150 °C respectively, which are 2.6 and 11.6 times higher than those of pure PI. This study provides new ideas for polymer‐based composite dielectrics in high energy storage.
Cationic [1,5]‐Aryl Migrations of Propargyl Benzyl Ethers – A Stereospecific Approach to E‐ and Z‐Tetrasubstituted Olefins
Authors: Sadhukhan Santu , Nair Sindoori R. , Baire Beeraiah 
Published: March 2024

AbstractHerein we report the discovery and development of the first example of a cationic [1,5]‐aryl migration reaction, through an unprecedented phenonium ions. This reaction does not require any acid, base, transition metal‐based catalyst or promoter, instead promoted by the water activated NXS reagents. It provides a highly diastereoselective and rapid access to the medicinally and biologically important tetra‐substituted olefins (allyl alcohols). The involvement of an ipso‐carbon, as well as the phenonium ion during this novel, cationic [1,5]‐aryl migration was strongly supported by the isolation of 2‐oxaspiro[5.5]undecane‐9‐ones. This methodology is highly tolerable for a wide range of propargyl‐benzyl ethers, resulting in a selective construction of structurally divergent library of mono‐halo‐tricarbon‐substituted alkenes. Synthetic application has also been demonstrated by converting two isomeric‐iodo‐olefins to respective E‐ and Z‐isomers of tamoxifen in a stereospecific manner.
Mechanical Field Guiding Structure Design Strategy for Meta‐Fiber Reinforced Hydrogel Composites by Deep Learning
Authors: Liu Chuanzhi , Zhang Xingyu , Liu Xia , Yang Qingsheng 
Published: March 2024

AbstractFiber‐reinforced hydrogel composites are widely employed in many engineering applications, such as drug release, and flexible electronics, with more flexible mechanical properties than pure hydrogel materials. Comparing to the hydrogel strengthened by continuous fiber, the meta‐fiber reinforced hydrogel provides stronger individualized design ability of deformation patterns and tunable stiffness, especially for the elaborate applications in joint, cartilage, and organ. In this paper, a novel structure design strategy based on deep learning algorithm is proposed for hydrogel reinforced by meta‐fiber to achieve targeted mechanical properties, such as stress and displacement fields. A solid mechanic model for meta‐fiber reinforced hydrogel is first developed to construct the dataset of fiber distribution and the corresponding mechanical properties of the composite. Generative adversarial network (GAN) is then trained to characterize the relationship between stress or displacement field, and meta‐fiber distribution. The well‐trained GAN is implemented to design meta‐fiber reinforced hydrogel composite structure under specific operation conditions. The results show that the deep learning method may efficiently predict the structure of the hydrogel composite with satisfied confidence, and has great potential for applications in drug delivery and flexible electronics.
Biomimetic Anticoagulated Porous Particles with Self‐Reporting Structural Colors
Authors: Chen Hanxu , Bian Feika , Luo Zhiqiang , Zhao Yuanjin 
Published: March 2024

AbstractAnticoagulation is vital to maintain blood fluidic status and physiological functions in the field of clinical blood‐related procedures. Here, novel biomimetic anticoagulated porous inverse opal hydrogel particles is presented as anticoagulant bearing dynamic screening capability. The inverse opal hydrogel particles possess abundant sulfonic and carboxyl groups, which serve as binding sites with multiple coagulation factors and inhibit the blood coagulation process. Owing to the variations of refractive index and pore sizes during the binding process, the particles appeared corresponding structure color variations, which can be adopted as sensory index of anticoagulation. Based on these features, a sensor containing these diverse structure color particle units is constructed for pattern recognition of coagulation factors level in clinical plasma samples. By analyzing the sensory information of the unit, the colorimetric “fingerprint” for each target can be obtained and summarized as a database. Besides, a portable test‐strip integrating sensory units is developed to distinguish the sample regarding abnormal coagulation factors‐derived diseases via multivariate data analysis. It is believed that such biomimetic anticoagulated structural color particles and their derived sensor will open new avenue for clinical detection and disease diagnosis.
Investigation of biofluorescence produced by the red king crab Paralithodes camtschaticus
Authors: Juhasz‐Dora Thomas , Thesslund Tina , Maguire Julie , Doyle Thomas K. , Lindberg Stein‐Kato 
Published: March 2024

AbstractBiofluorescence is widely documented in marine organisms, yet few studies exist for decapods. After observing the king crab Paralithodes camtschaticus biofluoresces, we carried out studies on two separately maintained groups of male crabs under controlled conditions. Hyperspectral imaging on Group 1 (n = 18) examined the exoskeleton, whereas fluorospectrometry examined the hemolymph of Group 2 animals (n = 19). Both groups were investigated for fluorescence signals before and after exposure to a live shipping transportation simulation. The spines, chelae, eyestalks and cervical grooves of the cardiac region of P. camtschaticus fluoresce in the green spectra (∼500 nm), while the arthrodial membranes of the joints fluoresce in the red spectrum (∼680 nm). After the shipping simulation, we observed a significant decrease in fluorescence in the eyestalks (p = 0.009), while the cervical grooves showed a less significant change (p = 0.01). The hemolymph examined with 21 excitation wavelengths (250–350 nm) emitted fluorescence in ∼400–550 nm spectrum. We found a significant increase (p < 0.05) in fluorescence for 16 excitation wavelengths after transport simulation. The results presented in this study indicate that king crab fluorescence changes due to external stimuli. Fluorospectroscopy or hyperspectral imaging technology may serve as an effective early indicator of preclinical stress in these commercially important decapods.
Overexpression of circular RNA hsa_circ_0008621 facilitates colorectal cancer progression and predicts poor prognosis
Authors: Zhou Xiaohu , Wu Lei , Tian Chunyan 
Published: March 2024

AbstractAimTo evaluate the potential role of serum and tissue hsa_circ_0008621 as a prognostic biomarker for CRC patients. Focused on the functional role of hsa_circ_0008621 in colorectal cancer (CRC).MethodsSerum and tissue hsa_circ_0008621 expression were quantified by qRT‐PCR in 157 CRC patients, as well as 100 serums from healthy controls. Serum and tissue hsa_circ_0008621 expression was evaluated for their prognostic role in CRC patients using Kaplan–Meier curves and Multivariate Cox proportional hazards analysis. To further characterize the biological role of hsa_circ_0008621 expression in CRC, in vitro hsa_circ_0008621 inhibition was performed and the effects on cellular growth, migration, invasion, apoptosis, and glycolysis were explored. Next, the downstream molecules for hsa_circ_0008621 were predicted.ResultsHsa_circ_0008621 expression was significantly upregulated in CRC tissues and serums. Serum hsa_circ_0008621 levels were significantly up‐regulated in advanced‐staged samples. High serum hsa_circ_0008621 expression was associated with shorter overall survival and recurrence‐free survival in CRC patients. Multivariate Cox regression analysis identified a high level of serum hsa_circ_0008621 expression as an independent prognostic factor with respect to overall survival and recurrence‐free survival. Loss of function assays for hsa_circ_0008621 in vitro led to a significant decrease in cell proliferation, migration, invasion, and glycolysis, but an increase in cell apoptosis. Hsa_circ_0008621 can sponge miR‐532‐5p, which targets SLC16A3.ConclusionHigh level of serum hsa_circ_0008621 is associated with poor survival in CRC and promotes CRC progression, suggesting it to be a promising non‐invasive prognostic biomarker and novel therapeutic target in CRC patients.
Pro‐Hemorrhagic Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Associated with NOTCH3 p.R75P Mutation with Low Vascular NOTCH3 Aggregation Property
Authors: Ishiyama Hiroyuki , Kim Hyunjin , Saito Satoshi , Takeda Soichi , Takegami Misa , Yamamoto Yumi , Abe Soichiro , Nakazawa Shinsaku , Tanaka Tomotaka , Washida Kazuo , Morita Yoshiaki , Oh Seung‐Taek , Jung Hee‐Jae , Choi Jay Chol , Nakaoku Yuriko , Nakahara Jin , Koga Masatoshi , Toyoda Kazunori , Amemiya Kisaki , Ikeda Yoshihiko , Hatakeyama Kinta , Mizuta Ikuko , Mizuno Toshiki , Kim Kwang‐Kuk , Ihara Masafumi 
Published: March 2024

ObjectivesIntracerebral hemorrhage (ICH) and cerebral microbleeds (CMB) in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy are more common in East Asian populations than in people of white European ancestry. We hypothesized that the ethnic difference is explained by the East Asian‐specific NOTCH3 p.R75P mutation.MethodsThis retrospective observational study included 118 patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy in Japanese and Korean cohorts. We investigated whether the p.R75P mutation is associated with symptomatic ICH and multiple CMB (>5) using quasi‐Poisson regression models. We predicted the NOTCH3 extracellular domain protein structures in silico and graded NOTCH3 extracellular domain immunostaining in skin vessels of some patients, with subsequent comparisons between p.R75P and other conventional mutations.ResultsAmong 63 Japanese patients (median age 55 years; 56% men), 15 had a p.R75P mutation, significantly associated with symptomatic ICH (adjusted relative risk 9.56, 95% CI 2.45–37.31), multiple CMB (3.00, 1.34–6.71), and absence of temporopolar lesions (4.91, 2.29–10.52) after adjustment for age, sex, hypertension, and antithrombotics. In the Korean cohort (n = 55; median age 55 years; 51% men), the p.R75P mutation (n = 13) was also associated with symptomatic ICH (8.11, 1.83–35.89), multiple CMB (1.90, 1.01–3.56), and absence of temporopolar lesions (2.32, 1.08–4.97). Structural analysis revealed solvent‐exposed free cysteine thiols in conventional mutations, directly causing aggregation, whereas a stereochemically incompatible proline residue structure in p.R75P lowers correct disulfide bond formation probability, indirectly causing aggregation. Pathologically, the p.R75P mutation resulted in less vascular NOTCH3 extracellular domain accumulation than the other conventional mutations.InterpretationNOTCH3 p.R75P mutation is associated with hemorrhagic presentations, milder temporopolar lesions, and distinct mutant protein structure properties. ANN NEUROL 2024;95:1040–1054
Hydrogen‐Bond‐Network Breakdown Boosts Selective CO2 Photoreduction by Suppressing H2 Evolution
Authors: Cong Die , Sun Jikai , Pan Yuwei , Fang Xu , Yang Li , Zhou Wei , Yu Tie , Li Zhen , Liu Chengcheng , Deng Wei‐Qiao 
Published: March 2024

AbstractConventional strategies for highly efficient and selective CO2 photoreduction focus on the design of catalysts and cocatalysts. In this study, we discover that hydrogen bond network breakdown in reaction system can suppress H2 evolution, thereby improving CO2 photoreduction performance. Photosensitive poly(ionic liquid)s are designed as photocatalysts owing to their strong hydrogen bonding with solvents. The hydrogen bond strength is tuned by solvent composition, thereby effectively regulating H2 evolution (from 0 to 12.6 mmol g−1 h−1). No H2 is detected after hydrogen bond network breakdown with trichloromethane or tetrachloromethane as additives. CO production rate and selectivity increase to 35.4 mmol g−1 h−1 and 98.9 % with trichloromethane, compared with 0.6 mmol g−1 h−1 and 26.2 %, respectively, without trichloromethane. Raman spectroscopy and theoretical calculations confirm that trichloromethane broke the systemic hydrogen bond network and subsequently suppressed H2 evolution. This hydrogen bond network breakdown strategy may be extended to other catalytic reactions involving H2 evolution.
Reduced Volume Expansion of Micron‐Sized SiOx via Closed‐Nanopore Structure Constructed by Mg‐Induced Elemental Segregation
Authors: Xu Di‐Xin , Zhao Yu‐Ming , Chen Han‐Xian , Lu Zhuo‐Ya , Tian Yi‐Fan , Xin Sen , Li Ge , Guo Yu‐Guo 
Published: March 2024

AbstractThe inherently huge volume expansion during Li uptake has hindered the use of Si‐based anodes in high‐energy lithium‐ion batteries. While some pore‐forming and nano‐architecting strategies show promises to effectively buffer the volume change, other parameters essential for practical electrode fabrication, such as compaction density, are often compromised. Here we propose a new in situ Mg doping strategy to form closed‐nanopore structure into a micron‐sized SiOx particle at a high bulk density. The doped Mg atoms promote the segregation of O, so that high‐density magnesium silicates form to generate closed nanopores. By altering the mass content of Mg dopant, the average radii (ranged from 5.4 to 9.7 nm) and porosities (ranged from 1.4 % to 15.9 %) of the closed pores are precisely adjustable, which accounts for volume expansion of SiOx from 77.8 % to 22.2 % at the minimum. Benefited from the small volume variation, the Mg‐doped micron‐SiOx anode demonstrates improved Li storage performance towards realization of a 700‐(dis)charge‐cycle, 11‐Ah‐pouch‐type cell at a capacity retention of >80 %. This work offers insights into reasonable design of the internal structure of micron‐sized SiOx and other materials that undergo conversion or alloying reactions with drastic volume change, to enable high‐energy batteries with stable electrochemistry.
Correlation between materials and band‐selective detection in organic photodetectors based on bulk heterojunction
Authors: Eynaud Quentin , Khodr Anass , Kramdi Mohamed El Amine , Quéléver Gilles , Margeat Olivier , Ackermann Jörg , Videlot‐Ackermann Christine 
Published: March 2024

AbstractFor wavelength‐selective photodetection or color discrimination, organic photodetectors (OPDs) can provide significant advantages as solution processability, chemical versatility and functionality. To eliminate the need for commonly used filters, the development of a narrowing approach that simultaneously achieves a selective detection range of less than 50 nm bandwidth and a spectral response of ~20% as efficiency at a required wavelength, remains a real challenge. Herein, different donor polymers and small acceptor molecules have been involved in bulk heterojunctions (BHJs) at 1:1 weight ratio as photoactive layers in specific OPDs. Indeed, the mechanism of charge collection in these OPDs is based on the charge collection narrowing (CCN) principle. In this approach, the detection window can be selected to match the absorption onset of the junction materials used in the BHJ layer. Although essentially based on very thick layers, we are focusing here on OPDs with layer thicknesses of less than 2 μm and post‐deposition annealing temperatures not in excess of 100°C.
Giving a voice to our silent teachers: Whole body donation from the donor perspective at one donation program in the United States
Authors: Bagian Lauren K. , Davis Danielle C. , Parker Ryan C. , Mosley Claudia F. , Balta Joy Y. 
Published: March 2024

AbstractHuman body donors play a crucial role in anatomical education, research, and clinical skills training, and those interested in anatomical donation may bequeath their bodies to body donation programs (BDPs). The purpose of this study was to evaluate the perspective of body donors on the donation process in order to make recommendations for improvement that align with donor values. A survey was administered via email to 2145 individuals that had enrolled in The Ohio State University's BDP and yielded a 40% response rate. Results showed that a majority of registered donors do not place high importance on detailed consent options during the enrollment process, but do value BDP oversight, such as through the use of an oversight committee to supervise the program. Only 9.1% of donors felt that their loved ones should be permitted to make changes to their consent forms after they have passed. Although 96.2% of participants would allow photos/videos to be taken of their donated bodies, females were significantly less likely to consent to this than males (p = 0.001), as well as less likely to allow their donations to be utilized for anatomy outreach (p = 0.023). Racial minorities were significantly less trusting of the university to treat their donation with dignity and respect compared to White registrants (p = 0.034). Suggestions for improving BDP protocols include the implementation of an annual newsletter for registrants, improving methods to spread awareness about donation, increasing transparency during the consent process, and creating resources for donors' families.
Environmental values and sustainable consumption
Authors: Perera Chamila R. , Kalantari Hassan D. , Johnson Lester W. 
Published: March 2024

AbstractThis special issue of the Journal of Consumer Behaviour engages in a scholarly debate on the association between environmental values and sustainable consumption using 16 studies that examine a range of exciting phenomena relevant to the debate. The special issue provides insights into three key areas of scholarly conversations in the field of study. First, it provides recent accounts of the literature on the role of environmental values in sustainable consumption. Given that the association between the two areas has been widely debated for decades, adding novel insights into the phenomenon in the context of recent environmental issues significantly contributes to the field of study. It should be noted that the novel insights cover several mediating and moderating factors of the association, which add new research directions to the field of study. Second, the special issue examines the recent discourse on environmental values considering the more specific behaviours (collaborative consumption, disposal behaviour, consumer engagement in circular economy) that are related to sustainable consumption. This discourse provides insight into environmentally conscious marketing practitioners. Third, the special issue highlights diverse consumer perspectives on sustainable consumption, especially those from diverse consumer generations, both local and international consumers. They inform global initiatives such as the UN sustainable development goals. Overall, engaging in a collective dialogue to understand recent developments in the field of study, the special issue informs environmental policies and fosters sustainable consumption and marketing practices that tackle climate change‐related environmental and social issues.