bluuebunny/crossref_metadata_2025_split huggingface dataset:
Separate (Asynchronous) Therapeutic Plasma Exchange (TPE) and Plasma Transfusion in the Patient with Severe TPE Complications: A Case Report
Authors: Anvari Saeid , Larijani Amirhossein , Ghorbannejad Nasim 
Published: February 2025

Thrombotic thrombocytopenic purpura (TTP) is a medical condition characterized by a decreased activity of the ADAMTS13 protease, which is responsible for cleaving the von Willebrand factor. It contributes to thrombotic microangiopathy. In this report, we described a case of TTP followed by significant adverse effects during therapeutic plasma exchange (TPE) treatment. The patient received TPE with a time interval from plasma transfusion.
A 30-year-old female was evaluated for headaches and bruises on her arms and legs. Laboratory testing revealed thrombocytopenia and anemia. The identification of thrombocytopenia with severe schistocytosis was verified by the analysis of a peripheral blood smear. After confirming a diagnosis of TTP, TPE was performed as therapy. To avoid the complications arising during the previous TPE sessions, we conducted plasma exchange with albumin followed by FFP injection, with a six-hour interval between them. This strategy successfully alleviated the patient's symptoms.
Therapeutic plasma exchange (TPE) with a time interval from plasma transfusion can be successfully used in patients with severe TPE complications.
WITHDRAWN: Relationships Between Temperature and Precipitation Conditions and Tree- Ring Growth in Küre Mountains National Park in the Context of Climate Change
Authors: ATAY Selinay , İRDEM Cemil 
Published: February 2025

Abstract

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Economic Growth and Income Inequality in Iraq: An Assessment of the Impact of Public Revenues and Transfers on Income Redistribution
Authors: Majeed Hawre Latif 
Published: February 2025

Abstract

Iraq's hydrocarbon wealth is a cornerstone of its Growth domestic product and government revenue, yet significant income inequality, as reflected by the Gini Index, poses persistent economic challenges. The unequal distribution of oil-derived income constrains public sector wages and investments, exacerbating social instability and impeding progress on the Human Development Index (HDI). Empirical analysis reveals a strong, consistent relationship between income inequality and developmental outcomes, with stationary trends indicating stable patterns over time. Addressing these disparities requires targeted interventions to promote sustainable growth. Reducing inequality and expanding opportunities for marginalized groups are essential. Leveraging information and communication technology to boost employment, alongside policies ensuring wage equity, labor inclusion, and social protection, can improve HDI outcomes. This study examines data spanning (1990 to 2024) to analyze Iraq's economic structure, employing robust empirical models that confirm these relationships. The analysis demonstrates high reliability, with no evidence of heteroskedasticity, serial correlation, or multicollinearity. Promoting equity across employment sectors and empowering collective bargaining are pivotal steps toward fostering a more inclusive and sustainable economic framework for Iraq.
Myeloid Cell Replacement Therapy Improves Function in Friedreich Ataxia Mice by Intercellular Mitochondrial Transfer
Authors: Gomez-Ospina Natalia , Cho Hyunmin , Sayana Ruhi , Koladiya Abhishek , Colella Pasqualina , Cho Sangkyun , Jahng James , Wu Joseph 
Published: February 2025

Abstract

Friedreich's ataxia (FA) is a mitochondrial disease caused by frataxin deficiency, leading to neurodegeneration and cardiomyopathy. Currently, there are no effective therapies for FA. Our study investigated the potential of myeloid cell replacement using bone marrow-derived cells in the YG8-800 mouse model. Combining Busulfan myeloablation, Colony-stimulating factor 1 receptor inhibition, and bone marrow transplantation, we achieved almost complete microglia and tissue macrophage replacement. This replacement facilitated mitochondrial transfer to various CNS cells, enhancing ATP synthesis and oxidative phosphorylation and improving the mice's growth and neurobehavioral performance. Similarly, replacing macrophages restored function and increased mitochondrial activity in the heart. In vitro studies showed that transferring intact mitochondria partially restored respiratory capacity in FA cells, which had a higher uptake, suggesting a specific compensatory mechanism for mitochondrial acquisition. These findings suggest that myeloid cell replacement can promote metabolic recovery in FA through mitochondrial transfer and provide a new approach to treating FA and other mitochondrial disorders.
The Impact of Intervertebral Disc Hydration on the Photothermal Responses and Carbonization Properties in Low-Energy Laser Therapy
Authors: Shiwen Li , Zhuan Zuo , Jiayuan Xu , Yang Liu , Wenyu Wang , Qi Liu , Valentinovich Ivanenko Andrei , Changshui Yu , Quan Qi 
Published: February 2025

Abstract

Purpose
Percutaneous Laser Disc Decompression (PLDD) is a minimally invasive treatment for lumbar disc herniation (LDH), but its effectiveness can be influenced by factors like laser power and treatment time, which vary with the degree of disc degeneration. Reduced water content in degenerated discs may affect treatment outcomes. This study examines how low-energy laser treatment impacts intervertebral discs with different water content, focusing on photothermal and carbonization effects.
Methods
Fresh intervertebral discs from adult pig spines (L2-L5) were used. Discs with poor and rich water content were prepared by vacuum freeze-drying and saline soaking, respectively, with untreated discs serving as controls. Three groups—poor, normal, and rich water content—were exposed to laser irradiation at 1W, 2W, and 3W. Images of the discs were captured, and the irradiated and carbonized areas were measured to evaluate photothermal effects.
Results
After 5 minutes of irradiation, the poor water content group showed the largest irradiated area at low power (112,894 ± 18,664 pixels), compared to the normal (75,644 ± 11,298 pixels) and rich (51,641 ± 7,348 pixels) groups. As power increased, the poor water content group continued to show a larger irradiated area. For carbonization, the poor water content group exhibited the largest carbonized area (64,759 ± 9,876 pixels) at low power, and this trend continued at higher powers.
Conclusion
The water content of intervertebral discs significantly affects laser irradiation and carbonization. Discs with poor water content show larger irradiated areas and earlier, more extensive carbonization. Careful control of treatment time is necessary when treating severely degenerated discs to avoid excessive carbonization and potential negative effects.
Cerebral autoregulation and optimal blood pressure from birth to surgery in neonates with critical congenital heart disease
Authors: Vasquez Angelica , Gentzler Eliza , Bateman David , Chaves Diana Vargas , Kalfa David , Bacha Emile , Krishnamurthy Ganga , Goldshtrom Nimrod 
Published: February 2025

Abstract

Objectives
Increased time-to-surgery has been correlated with increasing cerebral fractional oxygen extraction without compensatory increase in cerebral blood flow in neonates with critical congenital heart disease (cCHD) suggesting an overwhelmed cerebral autoregulation system. Autoregulation analysis can provide precision targets such as optimal blood pressure but it remains unclear how autoregulation evolves in days preceding surgery. Our hypothesis is that longer wait times between birth and surgery are associated with increasing periods of impaired autoregulation.
Methods
A retrospective observational study evaluating the time spent within optimal blood pressure (MAPOPT) range identified by cerebral autoregulation analysis in full term newborns with cCHD awaiting neonatal surgery.
Results
Sixty subjects had a median [IQR (interquartile range)] of 5.2 days [3.9–7.9] of recordings from birth to surgery. Subjects spent a median of 7.6%, [5.3–13%] with impaired autoregulation. Time within MAPOPT decreases slightly within the first ten days of life when controlling for confounders. Subjects spent a mean (+/- standard deviation) of 40.8% (± 15.5%) of each day within MAPOPT (51.3 ± 6.1 mmHg) and a median of 28.1% [13.6–45.5] time below MAPOPT. Mixed effects regression showed that subjects spent 1.93% less time each day within MAPOPT range (p = 0.001) over time but there was no difference in time spent below MAPOPT.
Conclusion
Full term neonates with cCHD experience variable periods of impaired autoregulation throughout the preoperative period and spend less time within MAPOPT over that time. These changes in cerebral hemodynamics may be a physiologic mechanism for previously described association between longer wait time to surgery and increased white matter injury.
Hydrocephalus: a rare complication in Guillain Barre Syndrome patients A case report and review of the literature
Authors: Jaiswar Sandeep 
Published: February 2025

Abstract

Guillain Barre syndrome is an autoimmune post-infectious polyneuropathy, which is characterized by ascending sym- metrical limb weakness, loss of tendon reflexes, absent or mild sensory signs, and variable autonomic dysfunctions. Hydrocephalus is an extremely rare complication of GBS. Here, we report our case of a 5-year-old boy who was diag- nosed of GBS had significant recovery on IVIG therapy. However, 4 weeks post admission, he developed hydro- cephalus. Here we highlight the significance of increased concentration of CSF protein to predict hydrocephalus in the course of recovery. In addition, this report is compared and contrasted with previous case reports in terms of manage- ment of the disorder. Moreover, we emphasize the importance of continuous monitoring of neurological advancements along with fundoscopy and neuroimaging studies.
The Nothapodytes nimmoniana genome provides insights into the independent evolution of camptothecin biosynthesis in asterids
Authors: Shen Xiaofeng , Shen Xiaofeng , Guan Zhijing , Sun Sijie , Du Ke , Zhao Yue , Yan Zhaojiu , Zhang Chuyi , Qiu Li , Yun Lingling , Shen Ruichi , Guo Bao-Lin , Shen Guoan , Li Xiwen , Wei Jianhe , Shi Linchun , Hu Zhigang , Xiang Li , Xu Jiang , Guo Shuai , Wei Sun , Xu Zhichao , Chen Wei , Leng Liang , Courdavault Vincent , Li Ying , Chen Shilin , Sun Chao 
Published: February 2025

Abstract

Nothapodytes nimmoniana is known to produce the highest content of the anticancer compound camptothecin (CPT) in the plant kingdom. We present the chromosome-level allotetraploid genome of N. nimmoniana, marking the first genome sequence from the order Icacinales. This 5-Gb genome encodes 92,630 genes, with subgenome B exhibiting dominant gene expression. Through genome mining, we identified and characterized four key enzymes involved in CPT biosynthesis, revealing that N. nimmoniana shares a similar prestrictosidine pathway with most monoterpene indole alkaloid-producing plants. Notably, homoeologous pairs of all characterized enzymes maintained their functions across both subgenomes, suggesting that gene duplication from allotetraploidization likely enhances CPT production in this species. Phylogenetic and syntenic analyses revealed that strictosidine synthase and strictosamide epoxidase were independently recruited in N. nimmoniana, Camptotheca acuminata, and Ophiorrhiza pumila, supporting the hypothesis that CPT biosynthesis evolved independently at least three times within the asterid clade.
Over-height Vehicle Impact Severity Assessment for Through-Plate Girder Railroad Bridges
Authors: Lawal Omobolaji , V.Shajihan Shaik Althaf , Golecki Thomas , Mechitov Kirill , Moreu Fernando , Spencer Billie 
Published: February 2025

Abstract

Low clearance railroad bridges in the United States are prone to frequent impacts from over-height vehicles, which can lead to structural damage and disruptions in railroad bridge service. Current practice mandates the closure of bridges after an impact is reported. However, this approach results in traffic delays and loss of revenue for railroad owners in cases of minor impacts, which occur far more frequently than major ones. While researchers have developed approaches to detect such impacts using acceleration responses obtained from sensors mounted on the bridge, the severity is generally difficult to ascertain. Therefore, there is a need for a reliable method to assess both the occurrence and severity of impacts. Although previous studies have used permanent displacement thresholds to rate impact severity, measuring permanent displacement is challenging and too expensive to be scalable. To address these challenges, this study proposes the use of an artificial neural network model to assess impact severity based on the impact impulse, peak acceleration, and spectral energy of detected impacts. The performance of the model is further validated using both simulated and field-collected impact data from a through-plate girder railroad bridge in northern Illinois. The results demonstrate that the developed approach reliably detects and determines the severity of impacts. This solution allows railroad owners to better prioritize the allocation of limited resources towards the inspection of bridges after major impacts.
A Novel ALTSRCFNN-STSMC Approach for Enhancing Ride-Through in Hybrid Renewable Systems
Authors: Lu Kai-Hung , Hong Chih-Ming 
Published: February 2025

Abstract

This paper proposes an innovative Adaptive Least Squares Recursive Chebyshev Fuzzy Neural Network (ALTSRCFNN) combined with Super-Twisting Sliding-Mode Control (STSMC) for improving the low-voltage ride-through (LVRT) capability and stability of hybrid generation systems (HGS) under grid faults. The integration of Static Synchronous Compensators (STATCOM) enhances system robustness by mitigating oscillations and stabilizing bus voltage during transient conditions. Simulation results demonstrate that the proposed method significantly outperforms conventional PID controllers and other neural network-based methods in terms of accuracy, response speed, and voltage regulation. The ALTSRCFNN-STSMC effectively reduces voltage fluctuations, restores steady-state conditions within shorter timeframes, and ensures sufficient active and reactive power delivery under various environmental conditions. These findings indicate the proposed approach’s potential for practical applications in modern power systems, particularly in addressing stability challenges in renewable energy integration.
The effect of climate change on meteorological drought and hydrological drought assessment in Kohgilouye and Boyer Ahmad Province of Iran
Authors: Alipour Modab Gholamreza 
Published: February 2025

ABSTRACT

Drought is a persistent environmental challenge with widespread and long-term impacts. Understanding the effects of climate change on drought is crucial for sustainable water resource management. This study assesses future drought conditions in Kohgiluyeh and Boyer Ahmad Province from 2024 to 2047 using the HADGEM3-GC31-LL model under SSP1.2-6 and SSP5.8-5 scenarios. Various drought indices, including standardized precipitation index, reconnaissance drought index, effective reconnaissance drought index (meteorological), standardized streamflow index (SSI) (hydrological), and groundwater resource index (groundwater), were applied to analyze precipitation, temperature, surface water discharge, and groundwater levels. Contrary to many studies predicting a decline in rainfall, our findings indicate an increase in precipitation and a slight decrease in temperature. The drought indices suggest that future conditions in the region will remain stable, with no significant intensification or mitigation of drought. These insights contribute to regional water management strategies by providing a refined understanding of climate-induced drought variability.
Design, Synthesis, and Antibacterial Activity of Carbazole Derivatives Containing 1,3,4-Oxadiazole Thioether Moiety
Authors: Tang Chenghao , Chen Liang , Yang Xiumei , Huang Jinying , Jiang Lixiang , Feng Siyan , Long Yinghai , Luo Yao , Li Pei , Wang Xiang 
Published: February 2025

Abstract:
A novel class of eighteen 2-((9H-carbazol-9-yl)methyl)-5-(benzylthio)-1,3,4-oxadiazole
derivatives were designed, synthesized and screened for their in vitro antibacterial activities against
Pseudomonas syringae pv. Actinidiae (Psa), Xanthomonas oryzae pv. Oryzae (Xoo) and Xanthomonas
axonopodis pv. Citri (Xac). Preliminary bioactivity test results indicated that some compounds
showed moderate to good inhibitory effects against the tested bacteria at the concentrations of 100
μg/mL and 50 μg/mL. Among them, compounds 2-((9H-carbazol-9-yl)methyl)-5-((2,6-dichloro benzyl)
thio)-1,3,4-oxadiazole (5e) and 2-((9H-carbazol-9-yl)methyl)-5-((4-(trifluoromethyl)benzyl)
thio)-1,3,4-oxadiazole (5m) exhibited the best inhibitory effects against Psa, Xoo and Xac than other
compounds, which displayed a wide range of antibacterial activities. Further bioactive applications of
these molecules are in progress in our laboratories.
The Incidence of Heart Failure in Children with Congenital Heart Disease: A Prospective Cohort Study
Authors: Moeinipour Yasamin , Moeinipour Aliasghar , Alizadeh Behzad , Raesi Rasoul , Naghibi Mohammadreza 
Published: February 2025

Background:
Pediatric heart failure (HF) poses diagnostic challenges, especially in
emergency settings, where misdiagnoses are common.

Aim:
This study aimed to investigate the causes of HF in children with congenital heart disease
(CHD) and provide insights into age-related disparities and clinical classifications.

Methods:
A prospective observational cohort study was conducted on 402 pediatric patients
with CHD during the years 2019-2020. Ultimately, 45 pediatric patients diagnosed with HF by
two pediatric cardiologists based on clinical symptoms and radiographic changes were included
in the study. Information from the patients' files, including epidemiological findings, clinical
examinations, paraclinical findings, and interventions performed, was recorded. Etiological factors
and clinical classifications were analyzed using statistical tests.

Results:
Among 402 pediatric patients with CHD, 45 (11.19%) were diagnosed with HF, with a
median age of 7.5 months. The predominant etiological factors included ventricular septal defect
(VSD), atrial septal defect (ASD), and cardiomyopathy. CHD was prevalent in 86.66% of
the cases. Clinical classifications revealed age-related differences, emphasizing the heterogeneity
of pediatric HF presentations.

Conclusion:
Considering that 86.7% of the patients with HF in our study had CHD, more investigations
into the causes and mechanisms of this issue are necessary, which will be possible with
genetic studies. A significant difference was observed between Class II and Class IV, with Class
II patients being older and heavier, and having a lower heart rate compared to those in Class IV.
This aligns with the classifications, where Class II indicates mild symptoms during ordinary activity,
while Class IV signifies severe symptoms at rest.
Normative Data for Objective ADHD Smartphone Application in a General Population
Authors: Gustafsson Urban , Nolen Robert , Casals Nuria , Larsson Simon , Sanyal Ragini , Hansen Mikkel 
Published: February 2025

Background
Normative data for objective measures in the clinical assessment of Attention Deficit Hyperactivity Disorder (ADHD) are crucial for enhancing the accuracy, reliability, and clinical utility of diagnostic tools. This observational study aimed to establish normative demographic data in a representative population for an investigational version of QbMobile (QbMobile), a software application for the administration of a performance test to provide objective measurements of hyperactivity, inattention, and impulsivity in the clinical assessment of ADHD.

Methods
This study was conducted in the United Kingdom, The Netherlands, Germany, and the United States. Participants between 6-60 years were included. The QbMobile application was pre-installed on the smart device/iPhone. Participants were instructed to sit holding the smartphone with both hands and tap the screen each time a target stimulus appeared on-screen and withhold tapping to all other stimuli. The smartphone tracked the participants' movements with the camera and movements from the smartphone to measure activity.

Results
A total of 2541 participants completed the study, n=326 aged 6-11 years and n=2215 aged 12-60 years. There were more females (55.7%) than males (44.3%). Demographic and characteristics variables had no impact on the data collected. Household income and educational levels were investigated to ensure sufficient spread across countries. The basic parameters of QbMobile were captured and evaluated during the assessment. There was a high degree of acceptance of the test, and 94% reported that the application was easy to use.

Conclusion
Representative normative data for QbMobile was established from a multinational general population and should provide a useful basis as a comparator for other datasets, such as people with ADHD.