bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transforming Pharmaceutical Synthesis with Sein‐E‐B Nanocomposite Photocatalyst through 1,4‐NAD(P)H Cofactor Regeneration and C‐N Bond Activation
Authors: Shukla Ravindra K. , Yadav Rajesh K. , Gole Vitthal L. , Singhal Rajat , Shahin Rehana , Mishra Shaifali , Singh Satyam , Sharma Kanchan , Baeg Jin‐Ook , El‐Hiti Gamal A. , Kumar Yadav Krishna , Kumar Gupta Navneet 
Published: April 2024

AbstractThe need for sunlight chemical renewal and contemporary organic transformation has fostered the advancement of environmentally friendly photocatalytic techniques. For the first time, we report on the novel crafting of a bright future with selenium‐infused Eosin‐B (Sein‐E‐B) nanocomposite photocatalysts in this work. The Sein‐E‐B nanocomposite materials were created using a hydrothermal process for solar chemical regeneration and organic transformation under visible light. The synthesized samples were subjected to UV‐DRS‐visible spectroscopy, FT‐IR, SEM, EDX, EIS and XRD analysis. The energy band gap of the Sein‐E‐B nanocomposite photocatalyst was measured using UV‐DRS, and the result was around 2.06 eV. to investigate the generated Sein‐E‐B catalytic activity as a nanocomposite for 1,4‐NADH/NADPH re‐formation and C−N bond activation. This novel photocatalyst offers a promising alternative for the regeneration of solar chemicals and C−N bond creation between pyrrole and aryl halides.
Four Undescribed Stilbenoid Derivatives from the Aerial Parts of Dendrobium officinale with their α‐Glucosidase and α‐Amylase Inhibitory Activity
Authors: Hai Yen Pham , Thuy Hang Dan Thi , Huu Tai Bui , Thi Cuc Nguyen , Thanh Huong Phan Thi , Thi Dung Duong , Thi Trang Do , Van Hung Nguyen , Van Hieu Tran , Van Cuong Pham , Dinh Hoang Vu , Van Kiem Phan 
Published: April 2024

AbstractIn this study, four undescribed bibenzyl derivatives (1–4), together with seven known compounds (5–11) were isolated from the aerial parts of Dendrobium officinale. Their chemical structures were determined to be (7’S,8’S) ‐9′′‐acetyldendrocandin U (1), (7’S,8’S) ‐4′‐methoxydendrocandin T (2), (7’R,8’S) ‐dendrocandin B (3), (1S,2R) ‐5′′′‐methoxydendrofindlaphenol C (4) by analyzing of the spectroscopic data including HR‐ESI‐MS, 1D‐, and 2D‐NMR spectra. The absolute configurations of compounds 1–4 were determined by the electronic circular dichroism (ECD) spectra. Compounds 1–3, 5, 10 and 11 inhibited α‐glucosidase with the IC50 values ranging from 56.3 to 165.3 μM, compounds 1–3, 5, 7–10 inhibited α‐amylase with the IC50 values ranging from 65.2 to 177.6 μM.
One‐year initial efficacy and safety outcomes of the premounted dry‐pericardium Vienna self‐expandable transcatheter aortic valve system: A first‐in‐human VIVA feasibility study
Authors: Briedis Kasparas , Rumbinaite Egle , Aldujeli Ali , Briede Kamilija , Jurenas Martynas , Jakuska Povilas , Jankauskas Antanas , Ceponiene Indre , Lenkutis Tadas , Plisiene Jurgita , Benetis Rimantas , Zaliunas Remigijus 
Published: April 2024

AbstractBackgroundThe dry‐pericardium Vienna transcatheter aortic valve system is repositionable and retrievable, already premounted on the delivery system, eliminating the need for assembly and crimping of the device before valve implantation.MethodsThe VIVA first‐in‐human feasibility study, a prospective, nonrandomized, single‐center trial, evaluated the Vienna aortic valve in 10 patients with severe symptomatic aortic stenosis, who were at intermediate or high surgical risk. This study, registered at ClinicalTrials.gov (NCT04861805), focused on the safety, feasibility, clinical and hemodynamic performance of the Vienna system up to 1‐year follow‐up.ResultsThe mean patient age was 79 ± 5 years, 60% male. Valve sizes used: 26 mm (10%), 29 mm (30%), 31 mm (60%). Key hemodynamic improvements were significant: mean aortic valve pressure gradient (mmHg) decreased from 48.7 to 8.1, aortic valve area (cm2) increased from 0.75 to 1.91, and maximum jet velocity through the aortic valve (m/s) decreased from 4.41 to 1.95 (p < 0.0001). No moderate/severe paravalvular leakage was observed, and computed tomography scans revealed no evidence of hypo‐attenuated leaflet thickening. The study recorded one life‐threatening bleeding event, two cases requiring postprocedural pacemaker implantation, and three ischemic events, with only one causing lasting neurological impairment. Importantly, there were no cases of cardiovascular mortality and only one noncardiovascular death, which was confirmed as unrelated to the device.ConclusionsThe study indicates the Vienna valve as a potential option for severe symptomatic aortic stenosis, designed to streamline the procedure and potentially lower healthcare costs by reducing resource and equipment needs, also procedural errors. Further research is essential to thoroughly evaluate its safety and efficacy.
Highly Efficient and Thermally Durable Luminescence of 1D Eu3+ Coordination Polymers with Arsenic Bridging Ligands
Authors: Shimoji Haruki , Aoyama Yuto , Inage Kota , Nakamura Masashi , Yanagihara Takumi , Yuhara Kazuhiro , Kitagawa Yuichi , Hasegawa Yasuchika , Ito Shunichiro , Tanaka Kazuo , Imoto Hiroaki , Naka Kensuke 
Published: April 2024

AbstractIn this work, bisarsine oxides were evaluated as novel bridging ligands, aiming to develop practical and efficient luminescent lanthanide coordination polymers. We have synthesized one‐dimensional (1D) Eu3+ coordination polymers that incorporate bisarsine oxide bridging ligands and hexafluoroacetylacetonate anions. These polymers exhibited a denser packing of chains compared to analogous polymers bridged with bisphosphine oxides. The coordination polymers demonstrated exceptional thermal stability and substantial emission quantum yields. Additionally, the bisarsine oxides induced a pronounced polarization effect, facilitating a sensitive electric dipole transition that yields considerably narrow band red emission. Remarkably, the Eu3+ coordination polymers with bisarsine oxides maintained intense emission even at 550 K. A distinctive feature of these polymers is their heating‐induced emission enhancement observed when the temperature was increased from 300 K to 400 K.
Luminescent Supramolecular Metallogels: Drug Loading and Eu(III) as Structural Probe
Authors: Freire Rafael V. M. , Coelho Dhiego M. A. , Maciel Larissa G. , Jesus Larissa T. , Freire Ricardo O. , dos Anjos Janaína V. , Junior Severino A. 
Published: April 2024

AbstractSupramolecular metallogels combine the rheological properties of gels with the color, magnetism, and other properties of metal ions. Lanthanide ions such as Eu(III) can be valuable components of metallogels due to their fascinating luminescence. In this work, we combine Eu(III) and iminodiacetic acid (IDA) into luminescent hydrogels. We investigate the tailoring of the rheological properties of these gels by changes in their metal:ligand ratio. Further, we use the highly sensitive Eu(III) luminescence to obtain information about the chemical structure of the materials. In special, we take advantage of computational calculations to employ an indirect method for structural elucidation, in which the simulated luminescent properties of candidate structures are matched to the experimental data. With this strategy, we can propose molecular structures for different EuIDA gels. We also explore the usage of these gels for the loading of bioactive molecules such as OXA, observing that its aldose reductase activity remains present in the gel. We envision that the findings from this work could inspire the development of luminescent hydrogels with tunable rheology for applications such as 3D printing and imaging‐guided drug delivery platforms. Finally, Eu(III) emission‐based structural elucidation could be a powerful tool in the characterization of advanced materials.
Phosphine‐Catalyzed 1,2‐cis‐Diboration of 1,3‐Butadiynes
Authors: Li Weipeng , Ricker Robert , Lok Chan Ka , Fung Lau Pak , Buchbinder Nicklas W. , Krebs Johannes , Friedrich Alexandra , Lin Zhenyang , Santos Webster L. , Radius Udo , Marder Todd B. 
Published: April 2024

AbstractTrialkyl phosphines PMe3 and PEt3 catalyze the 1,2‐cis‐diboration of 1,3‐butadiynes to give 1,2‐diboryl enynes. The products were utilized to synthesize 1,1,2,4‐tetraaryl enynes using a Suzuki‐Miyaura protocol and can readily undergo proto‐deborylation.
Blue‐ and Red‐Shifting C−H⋯O Hydrogen Bonds of Cyclic Ethers with Haloforms: Effect of Ring‐Size and Consistency with Bent's Rule
Authors: Paul Bijan K. 
Published: April 2024

AbstractA DFT‐based computational study is carried out to delve into the interplay between hyperconjugation and rehybridization effects underlying the formation of blue‐ or red‐shifting H‐bonds (HBs) in 1 : 1 complexes of cyclic ethers (HB acceptor) of varying ring‐size with haloforms, CHF3 and CHCl3 (HB donor). The calculations reveal that with decreasing angular strain (increasing ring‐size) of the cyclic ethers, the extent of blue‐shift increases for 1 : 1 complexes with CHF3, while a reverse sequence is observed with CHCl3, eventually leading to a red‐shifting HB in the oxepane : CHCl3 complex. It is noted that the trend in the shift of C−H stretching fundamental is not mirrored by the C−H bond length or interaction energies for both the systems studied, that is, the low sensitivity of the changes on the strain on the O‐atom of HB acceptor (cyclic ethers) is to be emphasized.
Tungsten Oxide Dispersed on Silica as Robust and Readily Available Oxo/Imido Heterometathesis Catalyst
Authors: Bushkov Nikolai S. , Rumyantsev Andrey V. , Zhizhin Anton A. , Strelkova Tatyana V. , Novikov Roman A. , Gutsul Evgenii I. , Takazova Rina U. , Kitaeva Dinara K. , Ustynyuk Nikolai A. , Zhizhko Pavel A. , Zarubin Dmitry N. 
Published: April 2024

AbstractContinuing our investigation of catalytic oxo/imido heterometathesis as novel water‐free method for C=N bond construction, we report here the application of classical transition metal oxides dispersed on silica (MOx/SiO2, M=V, Mo, W) as cheap, robust and readily available alternative to the catalysts prepared via Surface Organometallic Chemistry (SOMC). The oxide materials demonstrated activity in heterometathetical imidation of ketones, WO3/SiO2 being the most efficient. We also describe a new well‐defined supported W imido complex (≡SiO)W(=NMes)2(Me2Pyr) (Mes=2,4,6‐Me3C6H2, Me2Pyr=2,5‐dimethylpyrrolyl) and characterize it with SOMC protocols, which allowed us to identify the position of W on the oxo/imido heterometathesis activity scale (Mo<W<Ta) and showed that W in fact provides an optimal balance between activity and stability. Noteworthy, the performance of WO3/SiO2 was only slightly inferior to that of the SOMC analog enabling the efficient synthesis of a broad range of ketimines hardly accessible by classical methods, in most cases W being a competitive and robust alternative to the most active albeit highly sensitive Ti imido systems. Combined with the availability of the catalyst, this facilitates a more widespread application of heterometathesis methodology in organic synthesis including potential larger scale applications.
Transparent Conductive Titanium and Fluorine Co‐doped Zinc Oxide Films
Authors: Ramzan Iqra , Borowiec Joanna , Parkin Ivan P. , Carmalt Claire J. 
Published: April 2024

AbstractAerosol‐assisted chemical vapor deposition (AACVD) was used to deposit highly transparent and conductive titanium or fluorine‐doped and titanium‐fluorine co‐doped ZnO thin films on glass substrate at 450 °C. All films were characterized by X‐ray photoelectron spectroscopy (XPS), X‐ray diffraction (XRD), UV‐Vis spectroscopy, scanning electron spectroscopy (SEM), and four‐point probe. The films were 600–680 nm thick, crystalline, and highly transparent (80–87 %). The co‐doped film consisted of 0.70 at % titanium and 1 at % fluorine, and displayed a charger carrier mobility, charge carrier concentration, and a minimum resistivity of 8.4 cm2 V−1 s−1, 3.97×1020 cm−3, and 1.69×10−3 Ω cm, respectively. A band gap of 3.6 eV was observed for the co‐doped film. Compared to the undoped and singly doped films, the co‐doped film displayed a notably higher structure morphology (more homogenous grains with well‐defined boundaries) suitable for transparent conducting oxide applications.
Influence of Cerium Oxide Abrasive Particle Morphologies on Polishing Performance
Authors: Ni Zifeng , Fan Qiang , Chen Guomei , Dai Mengjiao , Chen Zongyu , Bian Da , Qian Shanhua 
Published: April 2024

AbstractIn this study, two morphologies of cerium oxide (CeO2) abrasive particles, octahedral and spheroidal, are synthesized by solvothermal method using cerium nitrate hexahydrate (Ce(NO3)3‐6H2O) as raw material. Fourier infrared spectroscopy, X‐ray diffractometer (XRD) and scanning electron microscopy (SEM) are used to characterize the composition and morphology of CeO2 abrasive particles. The synthesized CeO2 is used for chemical mechanical polishing (CMP) of the Si surface of 6H‐SiC wafers, and the surface morphology of the polished wafers are observed using atomic force microscopy (AFM). After polishing with octahedral and spheroidal abrasive particles, the surface roughness of the wafers are 0.327 and 0.287 nm, and the material removal rates (MRR) are 870 and 742 nm h−1, respectively. Calculations comparing the ultraviolet absorption spectra and bandgap energies of the two types of abrasive particles as well as molecular dynamics (MD) simulations reveal that the synthesized octahedral CeO2 particles possessed stronger surface chemical activity and material removal performance.
Phase separations of strongly coupled fine particles and fine particle mixtures in plasmas
Authors: Totsuji Hiroo 
Published: April 2024

AbstractPhase separations in strongly coupled fine particles in plasmas are discussed and two‐component mixtures are simulated by molecular dynamics with the background plasma being treated as continuum. The system size of laboratory experiments is assumed and separations into phases with a common electron density of the background plasma are analyzed. Since the charge on fine particles increases approximately in proportion to the size, we expect the larger component with stronger coupling condensates from the mixture. Results expressed in terms of strengths of Coulomb coupling and screening of the larger component seem to be mostly similar to the one‐component case, at least in cases where the ratio of fine particle sizes is 2, and the mixing ratio is in the range from 0.25 to 0.75.
A direct analysis method using sheath flow probe electrospray ionisation‐mass spectrometry (sfPESI‐MS) to detect drug residues from fingerprint forensic gel lifts
Authors: Kim Ayoung , Kelly Paul F. , Turner Matthew A. , Reynolds James C. 
Published: April 2024

AbstractLatent fingerprints at crime scenes are frequently recovered using forensic gel‐lifters, which can help to preserve the crime scene and to enhance visualisation of traces such as blood or paint. In addition to providing fingerprint ridge detail, additional chemical information can also be recovered from gel lifts that may prove pertinent to an investigation. However, while DNA and metal ions have been shown to be able to be detected in gel‐lifted fingerprints, the determination of other types of chemical information such as the presence of drugs in gel‐lifted prints has not been previously shown. This study demonstrates the application of an ambient ionisation method, sheath flow probe electrospray ionisation‐mass spectrometry (sfPESI‐MS), to the direct analysis of gel‐lifted fingerprints. A model drug compound (zolpidem) is successfully detected from gel‐lifted prints from three different surface types: glass, metal, and paper. The surface activity‐based separation associated with probe electrospray approaches is shown to resolve zolpidem ions from background phthalate species, significantly enhancing the response obtained from the gel‐lifter. A depletion series experiment shows that the drug residue can be detected with up to 100% efficiency after eight consecutive contacts; however, detection efficiency drops to 20% after 30 contacts. The developed approach has potential application to analysis of historical gel‐lifters to obtain additional chemical information.
Insertion of a neomycin selection cassette in the Amigo1 locus alters gene expression in the olfactory epithelium leading to region‐specific defects in olfactory receptor neuron development
Authors: Raja Reesha , Dumontier Emilie , Phen Alina , Cloutier Jean‐François 
Published: April 2024

SummaryDuring development of the nervous system, neurons connect to one another in a precisely organized manner. Sensory systems provide a good example of this organization, whereby the composition of the outside world is represented in the brain by neuronal maps. Establishing correct patterns of neural circuitry is crucial, as inaccurate map formation can lead to severe disruptions in sensory processing. In rodents, olfactory stimuli modulate a wide variety of behaviors essential for survival. The formation of the olfactory glomerular map is dependent on molecular cues that guide olfactory receptor neuron axons to broad regions of the olfactory bulb and on cell adhesion molecules that promote axonal sorting into specific synaptic units in this structure. Here, we demonstrate that the cell adhesion molecule Amigo1 is expressed in a subpopulation of olfactory receptor neurons, and we investigate its role in the precise targeting of olfactory receptor neuron axons to the olfactory bulb using a genetic loss‐of‐function approach in mice. While ablation of Amigo1 did not lead to alterations in olfactory sensory neuron axonal targeting, our experiments revealed that the presence of a neomycin resistance selection cassette in the Amigo1 locus can lead to off‐target effects that are not due to loss of Amigo1 expression, including unexpected altered gene expression in olfactory receptor neurons and reduced glomerular size in the ventral region of the olfactory bulb. Our results demonstrate that insertion of a neomycin selection cassette into the mouse genome can have specific deleterious effects on the development of the olfactory system and highlight the importance of removing antibiotic resistance cassettes from genetic loss‐of‐function mouse models when studying olfactory system development.
Type 2 vomeronasal receptor‐A4 subfamily: Potential predator sensors in mice
Authors: Rocha Andrea , Nguyen Quynh Anh Thi , Haga‐Yamanaka Sachiko 
Published: April 2024

SummarySensory signals detected by olfactory sensory organs are critical regulators of animal behavior. An accessory olfactory organ, the vomeronasal organ, detects cues from other animals and plays a pivotal role in intra‐ and inter‐species interactions in mice. However, how ethologically relevant cues control mouse behavior through approximately 350 vomeronasal sensory receptor proteins largely remains elusive. The type 2 vomeronasal receptor‐A4 (V2R‐A4) subfamily members have been repeatedly detected from vomeronasal sensory neurons responsive to predator cues, suggesting a potential role of this receptor subfamily as a sensor for predators. This review focuses on this intriguing subfamily, delving into its receptor functions and genetic characteristics.
Diversification of the VH3‐53 immunoglobulin gene segment by somatic hypermutation results in neutralization of SARS‐CoV‐2 virus variants
Authors: Bruhn Matthias , Obara Maureen , Salam Abdus , Costa Bibiana , Ziegler Annett , Waltl Inken , Pavlou Andreas , Hoffmann Markus , Graalmann Theresa , Pöhlmann Stefan , Schambach Axel , Kalinke Ulrich 
Published: April 2024

AbstractCOVID‐19 induces re‐circulating long‐lived memory B cells (MBC) that, upon re‐encounter with the pathogen, are induced to mount immunoglobulin responses. During convalescence, antibodies are subjected to affinity maturation, which enhances the antibody binding strength and generates new specificities that neutralize virus variants. Here, we performed a single‐cell RNA sequencing analysis of spike‐specific B cells from a SARS‐CoV‐2 convalescent subject. After COVID‐19 vaccination, matured infection‐induced MBC underwent recall and differentiated into plasmablasts. Furthermore, the transcriptomic profiles of newly activated B cells transiently shifted toward the ones of atypical and CXCR3+ B cells and several B‐cell clonotypes massively expanded. We expressed monoclonal antibodies (mAbs) from all B‐cell clones from the largest clonotype that used the VH3‐53 gene segment. The in vitro analysis revealed that some somatic hypermutations enhanced the neutralization breadth of mAbs in a putatively stochastic manner. Thus, somatic hypermutation of B‐cell clonotypes generates an anticipatory memory that can neutralize new virus variants.
Systematic Investigation of Optical and Chiroptical Properties of Chiral π‐Conjugated Oligomers in Solution and Thin Films
Authors: Albano Gianluigi , Taddeucci Andrea , Zinna Francesco , Aronica Laura Antonella , Pescitelli Gennaro , Di Bari Lorenzo 
Published: April 2024

AbstractFour families of structurally related chiral π‐conjugated oligomers bearing a hydroquinone (HQ), 1,5‐dihydroxynaphthalene (Naph), benzo[1,2‐b:4,5‐b’]dithiophene‐4,8‐diol (BDT) or 9H‐carbazole (CBZ) central core, for a total of 11 new compounds, have been synthesized by simple and versatile synthetic strategies involving Pd‐catalyzed cross‐coupling protocols: a Suzuki‐Miyaura reaction, a Sonogashira/desilylation/Sonogashira sequence or a Sonogashira/desilylation/acyl Sonogashira sequence. A systematic investigation of the optical and chiroptical features of the final chiral dyes was performed in chloroform solution and on spin‐coated thin films. The ECD investigation was crucial in revealing that, even within the same family of organic dyes, minor variations in the nature and length of the π‐conjugated backbone can result in very different solid‐state arrangements at different hierarchical scales.
A flexible GOx/PB/Au film biosensor for the detection of glucose
Authors: Cai Kaiwei , Bao Yin , Liu Yichen , Li Bingling 
Published: April 2024

AbstractPolystyrene (PS), a polymer material renowned for its notable optical and mechanical properties, as well as low cost and ease of processing, stands as one of optimal candidate for flexible electrode substrate materials. However, prevalent modification techniques such as lithography, electron beam evaporation, and plasma etching all entail the requirement for specialized equipment and precise operation, thereby significantly elevating the technical barrier. In this study, we introduce a chemical plating method to fabricate a gold film electrode, coupled with prussian blue (PB) and glucose oxidase (GOx), for the development of a glucose electrochemical biosensor. This process offers simplicity, cost‐effectiveness, and feasibility under regular experimental conditions. The electrode surface is covered with numerous gold nanoparticles, effectively augmenting the actual electrode area and enhancing electron transfer efficiency. Remarkably, without the addition of sensitizing agents, the biosensor achieves highly sensitive glucose detection. The proposed biosensor exhibits a broad linear relationship in the concentration range of 0.005–1 mM, with a detection limit of 4.4 μM. Moreover, it exhibits favorable performance in detecting glucose levels in sweat samples, showcasing promising prospects for personal healthcare diagnostics.