bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fetal cortisol response to intrauterine microbial colonisation identified by the polymerase chain reaction and fetal inflammation
Authors: Miralles R , Hodge R , Kotecha S 
Published: April 2007

Objective:To determine the fetal cortisol response to intrauterine infection.Study design:16s ribosomal RNA genes or the urease genes ofUreaplasmaspp were identified by the polymerase chain reaction in intrauterine samples. Cord blood cortisol, interleukin 6 (IL6) and IL8 were measured in samples from 31 infants born at <32 weeks gestation.Results:13 infants (median gestation 30 weeks, birth weight 1350 g) had at least one positive intrauterine sample for microbial genes and 18 infants (31 weeks, 1320 g) did not. The cord blood cortisol concentration was significantly higher in fetuses exposed to intrauterine infection and significantly increased in fetuses/mothers presenting in preterm labour with intact membranes compared with infants delivered by elective prelabour caesarean section (p<0.05). The cord blood cortisol concentration was increased in the mothers with prelabour premature rupture of membranes but this was not significant compared with the caesarean section group. The cord blood cortisol concentration was significantly increased in the presence of chorioamnionitis or funisitis and was moderately correlated with cord blood IL6 (r = 0.64, p<0.01) and IL8 (r = 0.52, p<0.01).Conclusions:In this study, cord blood cortisol was increased in the colonised group compared with non-colonised infants. It is unclear if infants born following prelabour premature rupture of the membranes mount an adequate anti-inflammatory response.
DOES MONEY TELL US ANYTHING ABOUT INFLATION IN NIGERIA?
Authors: ADEBIYI MICHAEL ADEBAYO 
Published: April 2007

This paper seeks to establish whether or not monetary aggregates M1 and M2 have useful information for forecasting inflation, other than that provided by inflation itself. The study is approached in two ways. First, it conducts forecasting experiments, using mean absolute percentage errors (MAPEs). It then evaluates whether each monetary variable improves the forecasts of a simple autoregressive (AR) (1) model of inflation or not. The study reveals that the MAPEs for all the variables are less than that of the benchmark AR (1) model. This implies that all the variables examined serve as important information variables for price movements. Also, from the inflation equation, the paper reveals that monetary aggregate (M2), Treasury bill rate, deposit rate and exchange rates are significant in the equation, therefore concluding that these variables provide useful information in predicting inflation in Nigeria.
Down-Regulation of CD9 Expression during Prostate Carcinoma Progression Is Associated with CD9 mRNA Modifications
Authors: Wang Jia-Chi , Bégin Louis R. , Bérubé Nathalie G. , Chevalier Simone , Aprikian Armen G. , Gourdeau Henriette , Chevrette Mario 
Published: April 2007

Abstract
Purpose: Cluster-of-differentiation antigen 9 (CD9) protein, a member of the tetraspanin family, has been implicated in carcinogenesis of various human tumors. Although decreased expression of the CD82 tetraspanin protein, a close CD9 relative, is associated with prostate cancer progression, CD9 expression has not been analyzed in this malignancy.
Experimental Design: CD9 expression in human prostatic adenocarcinoma was analyzed by immunohistochemistry on 167 primary tumors and 88 lymph node or bone metastases. CD9 cDNA was sequenced from two human prostate cancer cell lines, prostatic adenocarcinoma, high-grade prostatic intraepithelial neoplasia (PIN), and normal prostatic tissues.
Results: Although CD9 was detected in the epithelium of normal prostatic tissues, reduced or loss of CD9 expression within neoplastic cells was observed in 24% of 107 clinically localized primary adenocarcinomas, 85% of 60 clinically advanced primary adenocarcinomas, 85% of 65 lymph node metastases, and 65% of 23 bone metastases. Difference in CD9 expression between clinically localized and advanced diseases was highly significant (P &lt; 1 × 10−7). Whereas there was no alteration of CD9 cDNA in normal tissues, all PC-3–derived cell lines, one PIN, and four prostatic adenocarcinomas harbored deletions in their CD9 cDNAs. Recurring CD9 point mutations were also found in PC-3M-LN4 cells, one PIN, and seven prostatic adenocarcinomas.
Conclusions: CD9 expression is significantly reduced and even lost during prostate cancer progression. Moreover, deletions and mutations of the CD9 mRNA may be associated with loss of protein expression observed in tumor cells. Our data suggest that CD9 inactivation may play an important role in prostate cancer progression.
Multiple Molecular Markers as Predictors of Colorectal Cancer in Patients with Normal Perioperative Serum Carcinoembryonic Antigen Levels
Authors: Wang Jaw-Yuan , Lin Shiu-Ru , Wu Deng-Chyang , Lu Chien-Yu , Yu Fang-Jung , Hsieh Jan-Sing , Cheng Tian-Lu , Koay Lok-Beng , Uen Yih-Huei 
Published: April 2007

AbstractPurpose: In this study, a high-sensitivity colorimetric membrane array method was used to detect circulating tumor cells (CTC) in the peripheral blood of colorectal cancer (CRC) patients with normal perioperative serum carcinoembryonic antigen (CEA) levels. This membrane array method was evaluated as a potential diagnostic and postoperative surveillance tool.Study Design: Membrane arrays consisting of a panel of mRNA markers that include human telomerase reverse transcriptase, cytokeratin-19, cytokeratin-20, and CEA mRNA were used to detect CTCs in the peripheral blood of 157 postoperative CRC patients with normal perioperative serum CEA levels and in 80 healthy individuals. Digoxigenin-labeled cDNA were amplified by reverse transcription-PCR from the peripheral blood samples, which were then hybridized to the membrane array. The sensitivity, specificity, and accuracy of membrane arrays for the detection of CTCs were then calculated.Results: Using the four markers in combination, expression of any three markers or all the four markers in this panel was significantly correlated with the clinicopathologic characteristics, including depth of tumor invasion, lymph node metastasis, tumor-node-metastasis stage, and postoperative relapse (all P &lt; 0.05). The interval between the detection of all four positive molecular markers and subsequent elevated CEA ranged from 3 to 8 months (median 6 months). The expression of all four mRNA markers was an independent predictor for postoperative relapse. CRC patients with all four mRNA markers expression showed a significantly poorer survival rate than those with less than four positive markers.Conclusions: The constructed membrane array method was helpful in the early prediction of postoperative relapse in CRC patients with normal perioperative serum CEA levels.
Tumor-stroma interactions in pancreatic ductal adenocarcinoma
Authors: Mahadevan Daruka , Von Hoff Daniel D. 
Published: April 2007

AbstractThe host stromal response to an invasive epithelial carcinoma is frequently called a desmoplastic reaction (DR) and is a universal feature of pancreatic ductal adenocarcinoma (PDA). This DR is characterized by a complex interplay between the normal host epithelial cells, invading tumor cells, stromal fibroblasts, inflammatory cells, proliferating endothelial cells, an altered extracellular matrix, and growth factors activating oncogenic signaling pathways by autocrine and paracrine mechanisms. Hence, the tumor microenvironment is a dynamic process promoting tumor growth and invasion through mechanisms likely to include anoikis resistance, genomic instability, and drug resistance. Cell coculture models, murine models (xenograft and genetic), and gene expression profiling studies on human PDA biopsies have identified several key molecules, such as collagen type I, fibronectin, laminin, matrix metalloproteinases (MMP) and their inhibitors (tissue inhibitors of MMP), growth factors (transforming growth factor β, platelet-derived growth factor, connective tissue growth factor, and hepatocyte growth factor), chemokines, and integrins as constituents of the DR. Despite these findings, it is unclear which molecular-cellular events initiate and drive desmoplasia in PDA. Accumulating evidence indicates that pancreatic stellate cells when activated switch to a myofibroblast phenotype that produces components of the extracellular matrix, MMPs, and tissue inhibitors of MMPs by activating the mitogen-activated protein kinase (extracellular signal-regulated kinase 1/2) pathway. Based on current evidence, several therapeutic strategies are been evaluated on identified potential therapeutic targets. This review summarizes our current understanding of the mechanisms that potentially drive the DR in PDA and future possibilities for therapeutic targeting of this critical process. [Mol Cancer Ther 2007;6(4):1186–97]
Predicting gefitinib responsiveness in lung cancer by fluorescence in situ hybridization/chromogenic in situ hybridization analysis of EGFR and HER2 in biopsy and cytology specimens
Authors: Daniele Lorenzo , Macrì Luigia , Schena Marina , Dongiovanni Diego , Bonello Lisa , Armando Enrico , Ciuffreda Libero , Bertetto Oscar , Bussolati Gianni , Sapino Anna 
Published: April 2007

Abstract
In non–small cell lung cancer (NSCLC), epidermal growth factor receptor (EGFR) mutational analysis is an excellent predictor of responsiveness to treatment with tyrosine kinase inhibitors, such as gefitinib. In up to 80% of NSCLCs, cytologic samples or endoscopic biopsies are the only specimens available for molecular analysis, but PCR amplification of DNA from small fixed and paraffin-embedded samples may create artifactual mutations. Fluorescence in situ hybridization (FISH) of EGFR and HER2 has been proposed as an alternative method of analysis. This project aimed to determine the optimal scoring method for FISH or chromogenic in situ hybridization (CISH) assays when analyzing small NSCLC samples to predict response. FISH or CISH analysis of EGFR and HER2 genes was done on 42 small samples derived from NSCLC patients treated with gefitinib. EGFR mutational analysis was done after quantity and quality controls of DNA. In seven of seven cases, a balanced increase in EGFR gene and chromosome 7 number was found to correlate with the presence of specific EGFR mutations. In addition, seven of seven cases with balanced EGFR/HER2 polysomy and two of three cases with balanced EGFR/HER2 trisomy responded to gefitinib (75% of responders). Instead, the EGFR mutations predicted only 7 of 12 (58%) of gefitinib-responsive patients. When only endoscopic biopsies or cytologic specimens are available, we propose using FISH/CISH for EGFR and HER2 as the test of choice for selecting patients for treatment with gefitinib and to consider as negative predictive factor the absence of EGFR/HER2 gene gain. [Mol Cancer Ther 2007;6(4):1223–9]
MUC4 Mucin Potentiates Pancreatic Tumor Cell Proliferation, Survival, and Invasive Properties and Interferes with Its Interaction to Extracellular Matrix Proteins
Authors: Chaturvedi Pallavi , Singh Ajay P. , Moniaux Nicolas , Senapati Shantibhushan , Chakraborty Subhankar , Meza Jane L. , Batra Surinder K. 
Published: April 2007

Abstract
MUC4, a transmembrane mucin, is aberrantly expressed in pancreatic adenocarcinomas while remaining undetectable in the normal pancreas. Recent studies have shown that the expression of MUC4 is associated with the progression of pancreatic cancer and is inversely correlated with the prognosis of pancreatic cancer patients. In the present study, we have examined the phenotypic and molecular consequences of MUC4 silencing with an aim of establishing the mechanistic basis for its observed role in the pathogenesis of pancreatic cancer. The silencing of MUC4 expression was achieved by stable expression of a MUC4-specific short hairpin RNA in CD18/HPAF, a highly metastatic pancreatic adenocarcinoma cell line. A significant decrease in MUC4 expression was detected in MUC4-knockdown (CD18/HPAF-siMUC4) cells compared with the parental and scrambled short interfering RNA–transfected (CD18/HPAF-Scr) control cells by immunoblot analysis and immunofluorescence confocal microscopy. Consistent with our previous observation, inhibition of MUC4 expression restrained the pancreatic tumor cell growth and metastasis as shown in an orthotopic mouse model. Our in vitro studies revealed that MUC4-associated increase in tumor cell growth resulted from both the enhanced proliferation and reduced cell death. Furthermore, MUC4 expression was also associated with significantly increased invasiveness (P ≤ 0.05) and changes in actin organization. The presence of MUC4 on the cell surface was shown to interfere with the tumor cell-extracellular matrix interactions, in part, by inhibiting the integrin-mediated cell adhesion. An altered expression of growth- and metastasis-associated genes (LI-cadherin, CEACAM6, RAC1, AnnexinA1, thrombomodulin, epiregulin, S100A4, TP53, TP53BP, caspase-2, caspase-3, caspase-7, plakoglobin, and neuregulin-2) was also observed as a consequence of the silencing of MUC4. In conclusion, our study provides experimental evidence that supports the functional significance of MUC4 in pancreatic cancer progression and indicates a novel role for MUC4 in cancer cell signaling. (Mol Cancer Res 2007;5(4):309–20)
Metacognition of Problem-Solving Strategies in Brazil, India, and the United States
Authors: Güss C. Dominik , Wiley Brian 
Published: April 2007

Abstract
Metacognition, the observation of one's own thinking, is a key cognitive ability that allows humans to influence and restructure their own thought processes. The influence of culture on metacognitive strategies is a relatively new topic. Using Antonietti's, Ignazi's and Perego's questionnaire on metacognitive knowledge about problem-solving strategies (2000), five strategies in three life domains were assessed among student samples in Brazil, India, and the United States (N=317), regarding the frequency, facility, and efficacy of these strategies. To investigate cross-cultural similarities and differences in strategy use, nationality and uncertainty avoidance values were independent variables. Uncertainty avoidance was expected to lead to high frequency of decision strategies. However, results showed no effect of uncertainty avoidance on frequency, but an effect on facility of metacognitive strategies. Comparing the three cultural samples, all rated analogy as the most frequent strategy. Only in the U.S. sample, analogy was also rated as the most effective and easy to apply strategy. Every cultural group showed a different preference regarding what metacognitive strategy was most effective. Indian participants found the free production strategy to be more effective, and Indian and Brazilian participants found the combination strategy to be more effective compared to the U.S. participants. As key abilities for the five strategies, Indians rated speed, Brazilians rated synthesis, and U.S. participants rated critical thinking as more important than the other participants. These results reflect the embedded nature and functionality of problem solving strategies in specific cultural environments. The findings will be discussed referring to an eco-cultural framework.
Heart and Cognition in Ancient Chinese Philosophy
Authors: Yu Ning 
Published: April 2007

AbstractFollowing the theory of conceptual metaphor in cognitive linguistics, this paper studies a predominant conceptual metaphor in the understanding of the heart in ancient Chinese philosophy: THE HEART IS THE RULER OF THE BODY. The most important conceptual mapping of this metaphor consists in the perceived correspondence between the mental power of the heart and the political power of the ruler. The Chinese heart is traditionally regarded as the organ of thinking and reasoning, as well as feeling. As such, it is conceptualized as the central faculty of cognition. This cultural conceptualization differs fundamentally from the Western dualism that upholds the reason-emotion dichotomy, as represented by the binary contrast between mind and heart in particular, and mind and body in general. It is found that the HEART AS RULER metaphor has a mirror image, namely THE RULER IS THE HEART OF THE COUNTRY. The ruler as the "heart" of the country leads his nation while guided by his own heart as the "ruler" of his body. It is argued that the two-way metaphorical mappings are based on the overarching beliefs of ancient Chinese philosophy in the unity and correspondence between the microcosm of man and the macrocosm of universe. It is suggested that the conceptualization of the heart in ancient Chinese philosophy, which is basically metaphorical in nature, is still spread widely across Chinese culture today.
Cognition, Algebra, and Culture in the Tongan Kinship Terminology
Authors: Bennardo Giovanni , Read Dwight 
Published: April 2007

Abstract
We present an algebraic account of the Tongan kinship terminology (TKT) that provides an insightful journey into the fabric of Tongan culture. We begin with the ethnographic account of a social event. e account provides us with the activities of that day and the centrality of kin relations in the event, but it does not inform us of the conceptual system that the participants bring with them. Rather, it is a slice in time of an ongoing dynamic process that links behavior with a conceptual system of kin relations and vice versa. To understand this interplay, we need an account of the underlying conceptual system that is being activated during the event. Thus, we introduce a formal, algebraically based account of TKT. is account brings to the fore the underlying logic of TKT and allows us to distinguish between features of the kinship system that arise from the logic of TKT as a generative structure and features that must have arisen through cultural intervention.
The role of attraction in cultural evolution
Authors: Claidière Nicolas , Sperber Dan 
Published: April 2007

AbstractHenrich and Boyd (2002) were the first to propose a formal model of the role of attraction in cultural evolution. They came to the surprising conclusion that, when both attraction and selection are at work, final outcomes are determined by selection alone. This result is based on a determistic view of cultural attraction, different from the probabilistic view introduced in Sperber (1996). We defend this probabilistic view, show how to model it, and argue that, when both attraction and selection are at work, both affect final outcomes.
Does the basic color terms discussion su er from the stimulus error?
Authors: Kuehni Rolf 
Published: April 2007

AbstractThis commentary raises the possibility of recent discussion on the issue of basic color terms suffering from the "stimulus error," first described by the English psychologist E. B. Titchener. It refers to confusion of the psychological experience with the physical description of the stimulus. Such confusion is routine in everyday language in situations where private sensory experiences are involved that cannot be objectively described, but is harmful in fundamental discussions about experiences.
Considering the Prevalence of the "Stimulus Error" in Color Naming Research
Authors: Jameson Kimberly , Bimler David , Dedrick Don , Roberson Debi 
Published: April 2007

Abstract
In "Does the Basic Color Terms discussion suffer from the Stimulus Error?" Rolf Kuehni describes a research stumbling block known as the "stimulus error," and hints at the difficulties it causes for mainstream color naming research (Kuehni, is Issue). Among the issues intrinsic to Kuehni's "stimulus error" description is the important question of what can generally be inferred from color naming behaviors based on bounded samples of empirical stimuli. Here we examine some specifics of the color naming research issues that Kuehni raises. While we share Kuehni's view regarding potential problems caused by the "stimulus error" and his concern regarding its prevalence, Kuehni's commentary seems primarily aimed at stimulating a general discussion of color naming research implications, because the articles he critiques do not actually commit the "stimulus error" in any serious sense. Based on Kuehni's comments, we further examine some of the relevant empirical and theoretical implications for cross-cultural color naming research.
THE JOINT CENTER FOR SATELLITE DATA ASSIMILATION
Authors: Le Marshall John , Uccellini Louis , Einaudi Franco , Colton Marie , Chang Simon , Weng Fuzhong , Uhart Michael , Lord Stephen , Riishojgaard Lars-Peters , Phoebus Patricia , Yoe James G. 
Published: April 2007

The Joint Center for Satellite Data Assimilation (JCSDA) was established by NASA and NOAA in 2001, with Department of Defense (DoD) agencies becoming partners in 2002. The goal of JCSDA is to accelerate the use of observations from Earth-orbiting satellites in operational environmental analysis and prediction models for the purpose of improving weather, ocean, climate, and air quality forecasts and the accuracy of climate datasets. Advanced instruments of current and planned satellite missions do and will increasingly provide large volumes of data related to the atmospheric, oceanic, and land surface state. During this decade, this will result in a five order of magnitude increase in the volume of data available for use by the operational and research weather, ocean, and climate communities. These data will exhibit accuracies and spatial, spectral, and temporal resolutions never before achieved. JCSDA will help ensure that the maximum benefit from investment in the space-based global observation system is realized. JCSDA will accelerate the use of satellite data from both operational and experimental spacecraft for weather and climate prediction systems. To this end, the advancement of data assimilation science by JCSDA has included the establishment of the JCSDA Community Radiative Transfer Model (CRTM), which has continual upgrades to allow for the effective use of current and many future satellite instruments. This and other activity within JCSDA have been supported by both internal and external (generally university based) research. Another key activity within JCSDA has been to lay the groundwork for and to establish common NWP model and data assimilation infrastructure for accessing new satellite data and optimizing the use of these data in operational models. As a result of this activity, common assimilation infrastructure has been established at NOAA and NASA and this will assist in a coordinated and integrated move to four-dimensional assimilation among the partner agencies.
This paper discusses the establishment of JCSDA and its mission, goals, and science priorities. It also discusses recent advances made by JCSDA, and planned future developments.