bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant Encroachment Increase Microbial Diversity, Network Complexity and Multifunctionality in Bauxite Residue
Authors: Deng Dandan , Sun Wei , Wu Hao , Yang Xiyun , Zhu Feng , Jiang Yifan , Huang Shiwei , Xue Shengguo , Jiang Jun 
Published: March 2024

Abstract

Purpose Long-term weathering promotes the development of the microbial communities and increased microbial diversity in bauxite residue. However, the effect of different vegetation cover on the diversity and stability of microbial community are still poorly understood.
Methods In this study, residue samples from three typical vegetation cover including Artemisia (BA), Cynodon (BC), and Hedysarum (BH) were collected in a bauxite residue deposit area. Illumina high-throughput sequencing technology was applied to determine the microbial communities in bauxite residue.
Results Residues in vegetated sites exhibited lower alkalinity and higher nutrients level, as well as higher microbial biomass and activities, suggesting that plant encroachment significantly increased multifunctionality in bauxite residue. In addition, plant encroachment also induced the development of microbial communities and increased microbial and enhanced network stability. Furthermore, our results showed that the microbial diversity and network stability were significantly positive correlated with multifunctionality in bauxite residue. Long-term plant encroachment promoted functional bacterial assemblages (mostly Rhizobiaceae, Blastocatellaceae, Acidobacteriaceae, Sphingonmonadaceae, Frankiaceae), which were also the core species in microbial network.
Conclusions Plant encroachment could increase microbial diversity and network stability, thus promote the elevation of multifunctionality in bauxite residue. Rhizobiaceae, Blastocatellaceae, Acidobacteriaceae, Sphingonmonadaceae, Frankiaceae played important roles in the promotion of multifunctionality in bauxite residue. Our results highlight the necessity of conserving and augmenting the abundance of functional bacterial assemblages to ensure the stable provision of ecosystem functions in bauxite residue disposal areas.
Interactions in bryophytes using a new in vitro culture method reveal negative and positive interspecific effects in the sporelings of two moss species
Authors: Gómez-Molinero Miguel A. , Estébanez Belén , Medina Nagore G. 
Published: March 2024

Abstract

In vitro culture experiments are crucial for the studies of chemical-mediated interactions in plants. However, distinguishing spores and sporelings of different species of bryophytes in mixed cultures poses a serious drawback for research on early developmental stages. Here we propose a modification of the sandwich technique, a standard method to explore allelopathic effect of plants, and present a case-study using two common mosses. As in the standard sandwich method, we have created a physical barrier using gelled medium, and inoculated spores of Tortula muralis and Syntrichia ruralis in two layers. To assess their intra- and interspecific interactions, we measured protonemata green coverage using image analysis, and degree of sporeling development using a categorical index. We successfully obtained physically separated sporelings of target and emitters from spores of these two species. The green-coverage analysis showed no differences in any of the comparisons. However, the developmental index shows a negative effect of T. muralis on S. ruralis, while S. ruralis apparently promotes the development of T. muralis. The method here proposed is successful for culturing moss spores, so that the different inocula are physically separated while allowing diffusion of water-soluble and volatile substances. For testing interactions in these early stages of the gametophyte, we recommend measuring the degree of development of moss sporelings rather than their coverage. Our results have revealed the existence of both positive and negative interspecific relationships between T. muralis and S. ruralis sporelings, supporting that positive interactions in bryophytes might be more common than previously thought.
Is Disinformation More Likely to Spread? Infodemic of Emerging Infectious Diseases Research on China’s Short Video Platform
Authors: Xu Yongbin , Wen Sanmei , Zhang Liwen , Su Jing 
Published: March 2024

Abstract

Background
People are increasingly focusing on the infodemic related to EIDs on social media. Concerns about infodemics have focused on managing health-related rumors on social media platforms. The infodemic has garnered attention due to the assumed logic that applies in the case of an EID outbreak: disinformation spreads faster and further than fact-checked information. However, it is worth scrutinizing whether this assumption is unchallengeable.
Methods
Focusing on Douyin (TikTok in mainland China), this study collected data from the top 500 trending short videos using “monkeypox” as the keyword from May 1 to December 31, 2022. Under the guidance of Health Belief Model (HBM), the videos were coded using two sets of variables: type variables that distinguished between fact-checked information and disinformation; and content variables that were used as condition variables. Moreover, in the information content variable, this study combined the characteristics of audiovisual media and Chinese public demand, introducing efficacy information into the content variable. The study then used fsQCA to analyze the correlation and consistency between the video contents and the level of public sharing, which was the outcome variable.
Results
The results showed that there are three configurations of short video content related to monkeypox which can trigger a high level of sharing among the general public. It has been found that the number of fact-checked cases in the most widely disseminated short videos of monkeypox is 21.8:1 to the number of disinformation cases. Therefore, it can be concluded that fact-checked information is more likely to spread than disinformation in the case of an outbreak of EIDs on China's short video platforms. Based on the analysis of the three configurations, we also found that they separately form three paths of the short video communication model, and each path has a more significant variable playing a central role. We named each pathway after the core variable, which are Authoritative Source Path, Personal Efficacy Path, and Disinformation Path.
Conclusions
This study developed a model for information dissemination of EIDs and found that instead of disinformation, fact-checked content is more likely to spread on Chinese short video platforms. It also explores public demand for guidance on EIDs precautions.
LncRNA TUG1 mitigates renal interstitial fibrosis through miR-542-3p / HIF-1α/VEGF axis
Authors: Qian Luoxiang , Hu wanru , Wang Yanping , Waheed YousufYousuf Abdulkarim , Hu Shuqun , Sun Dong , Li Shulin 
Published: March 2024

Abstract
Chronic kidney disease (CKD) has been discovered to be closely associated with both long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), while the precise molecular processes behind this relationship are still unclear. This study evaluated the impact of miR-542-3p and lncRNA-TUG1 on renal fibrosis, along with the regulatory mechanisms that underlie them. Through tube formation assays, in vitro research showed that TUG1 knockdown might both improve angiogenesis and heal damaged endothelial cell-cell connections. We used Western blot and q-PCR methods in the UUO model to identify tissue hypoxia and fibrotic lesions. Additionally, we employed a cutting-edge method known as fluorescence microangiography (FMA) to find damage to the peritubular capillaries (PTCs), and MATLAB software was utilized to evaluate the data. Furthermore, by looking at the coexpression of CD31 and a-SMA, we were able to identify cells in the obstructed kidney that were transitioning from endothelium tomyofibroblasts.Moreover, the reduction of tissue hypoxia brought on by lncRNA TUG1 knockdown was dramatically reversed by inhibition of miR-542-3p, which also decreased the expression levels of fibrotic indicators. To sum up, our findings offer fresh perspectives on how TUG1 and the miR-542-3p / HIF-1α / VEGF axis are regulated as renal fibrosis advances.
Validation of AERMOD prediction accuracy for particulate matters (PM10, PM2.5) for a large coal mine complex: A Multisource Perspective
Authors: Prasad Navin , Mishra Akash , Bhattacharya Tanushree , Lal Bindhu , Jha Prakash Chandra , Kumar Abhishek 
Published: March 2024

Abstract

Particulate matter (PM) emission from coal mining activities is inevitable and a significant concern worldwide. American Meteorological Society/Environmental Protection Agency Regulatory Model (AERMOD) is one of the most widely used dispersion models for predicting air PM dispersion in coal mines. However, validation of AERMOD-predicted PM concentration in a large mine complex has not been reported. So, in this study, AERMOD predicted PM concentration was validated against the PM concentrations measured by nine continuous ambient air quality monitoring stations (CAAQMS) stationed in the Singrauli coal mining complex. The complex contains nine coal mines across 438 square kilometers, with around 129 pollution sources chiefly from the area, pit, and line categories. PM10 and PM2.5 concentrations peak during summer (204.58 µg/m3) and winter (67.67 µg/m3), respectively. The AERMOD model predicts peak dispersion of PM10 (500–1200 µg/m3) and PM2.5 (100–800 µg/m3) during the winter season. The AERMOD model reveals that the region's wind movement caused by land and lake breezes was the predominant driver of PM surface dispersion. In the winter season, atmospheric inversion increases ground-level PM concentrations in the region. The AERMOD cannot represent the vertical dispersion of PMs in the summer, resulting in an underestimation of PM concentration. The statistical validation shows that AERMOD underestimates PM10 and PM2.5 concentrations across all seasons and years. The AERMOD model's prediction accuracy for PM10 (R2 = 0.38) and PM2.5 (R2 = 0.56) is also low. Finally, it can be concluded that AERMOD-predicted PM concentrations are not accurate for large mining complexes but more suitable for individual mines.
Isavuconazole Pharmacokinetics in Critically Ill Patients: Relationship with Clinical Effectiveness and Patient Safety
Authors: Martín-Cerezuela María , Maya-Gallegos Cristina , Miñana María Remedios Marqués , Porcar Maria Jesus Broch , Pardo Juan Carlos Mateo , Sanchez Andrés Cruz , Gimeno Ricardo , Ortega Alvaro Castellanos , Andrés José Luis Poveda , Galleymore Paula Ramírez 
Published: March 2024

Abstract
Background
Isavuconazole is a new drug used to treat fungal infections. This study aims to describe isavuconazole pharmacokinetics in critically ill patients, assess the potential influence of patient covariates, and evaluate the relationship with clinical efficacy and patient safety.
Methods
We conducted a prospective, observational study in critically ill patients treated with intravenous isavuconazole for at least 48 hours. Samples were collected between 48–96 hours of onset of treatment, at predose (Cmin), 1 hour (Cmax) and 12 hours (C50) after last dose. Plasma concentration was determined by a high-performance liquid chromatography with fluorescence detector. The relationship between plasma concentration and clinical and microbiological outcome, and safety was evaluated. The influence of covariates such as age, sex, weight, SAPS3, creatinine, bilirubin, liver enzymes and extracorporeal devices (continuous re-emplace renal therapy (CRRT) and extracorporeal membrane oxygenation (ECMO)) was analysed. Population pharmacokinetic modelling was performed using NONMEN®.
Results
A total of 71 isavuconazole samples from 24 patients were analysed. Mean Cmin was 1.76 (1.02) mg/L. Twenty-one patients (87.5%) reached the optimal therapeutic target, while three patients (12.5%) were below 1 mg/L. Population pharmacokinetic was best described by a one-compartimental model with first-order elimination. No factor, including CRRT or ECMO support, had a significantly impact on plasma concentration or pharmacokinetic parameters. No relationship was observed between isavuconazole plasma level and clinical effectiveness or adverse event appearance.
Conclusions
Isavuconazole use in critically ill patients at established doses was accompanied by plasma levels within the therapeutic range. This pharmacokinetic confidence remained independent of demographic, clinical, or therapeutic factors and did not affect the drug´s efficacy and safety.
Comparative Efficacy of Peptide-Based versus Standard Polymeric Enteral Nutrition in ICU Patients at High Nutritional Risk: A Multicenter Randomized Controlled Trial
Authors: Bhurayanontachai Rungsun , Wacharasint Petch , Somboonviboon Dujrath , Sawawiboon Chaiwut 
Published: March 2024

Abstract
Introduction:
Within intensive care units (ICU), the administration of peptide-based formulas (PBF) may confer nutritional advantages for critically ill patients identified with heightened nutritional risk. This investigation aimed to ascertain the efficacy of PBF in comparison to standard polymeric formulas (SPF) among this patient cohort.
Methods
A double-blind, randomized controlled trial was conducted across three ICUs, encompassing 63 adult patients characterized by elevated modified Nutrition Risk in Critically Ill (mNUTRIC) scores. Enrollment occurred promptly subsequent to ICU admission, with participants allocated to receive either PBF or SPF. Primary outcome was the duration to achieve caloric targets. Secondary outcomes involved the evaluation of mean daily gastric residual volume, mechanical ventilation period, infection rates within the ICU, length of hospitalization, mortality rates, nutritional status and inflammatory markers, specifically serum albumin and interleukin-6 levels.
Results
Patients in the PBF group reached their caloric targets more expeditiously compared to the SPF group (2.06 ± 0.43 days versus 2.39 ± 0.79 days; p = 0.03). No significant differences were discernible between the groups regarding gastric residual volume, duration of mechanical ventilation, ICU length of stay, mortality, or infection rates. Both cohorts exhibited minimal adverse effects and were devoid of any instances of abdominal distension. While not reaching statistical significance, the observed trends in albumin and interleukin-6 levels suggest a potential advantage of PBF utilization.
Conclusions
The implementation of PBF enabled swifter attainment of caloric goals in ICU patients at high nutritional risk without adversely impacting other clinical parameters. Given its favorable tolerance profile and potential immunomodulatory properties, PBF may be considered a valuable nutritional intervention in this setting.
Trial Registration
Thai Clinical Trials Registry TCTR20220221006. Registered 21 February 2022, https://www.thaiclinicaltrials.org/show/TCTR20220221006
The impact of perfluoroalkyl substances on the clinical manifestations of primary Sjögren syndrome
Authors: Zhao Yun , Jin Hangbiao , Hu Shetuan , Zhang Sunzhao , Zhao Meirong , Xue Jing 
Published: March 2024

Abstract
Background: The impact of environmental factors on genetically susceptible individuals constitutes a fundamental link in the pathogenesis of primary Sjögren Syndrome (pSS). Perfluoroalkyl substances (PFASs) are a class of synthetic organic fluorine chemicals that have been extensively manufactured and widely utilized over the past six decades, and they have also been identified as significant pollutants with adverse effects on human health. The impact of fluoride on the development of primary Sjögren's syndrome (pSS) remains uncertain. This study aims to investigate the correlation between common fluoride exposure and clinical manifestations of pSS.
Results: We designed a population-based case-control study in China and evaluated the association. A cohort of 136 patients with SS and 148 health controls in Second Affiliated Hospital of Zhejiang University School of Medicine were investigated. There were 4 male patients and 132 female patients in the pSS cohort. The concentrations of perfluoroundecanoate (PFUdA) in the pSS group exhibited statistically higher levels compared to those in the healthy control group. The concentration of perfluorononanoate (PFNA) was significantly lower in patients with leucopenia and thrombocytopenia compared to those without this condition. The serum levels of PFNA and perfluorodecanoate (PFDA) were found to be lower in patients with a high ANA titer compared to those with a low ANA titer. The serum levels of PFNA were found to be lower in patients with Anti-SSA positive compared to those with anti-SSA negative.
Conclusion: The levels of serum fluorides may be correlated with the disease activity in patients with pSS, and there might be an association between fluoride and the onset of pSS.
Evaluation of the Performance of a Pcbn Tool in Turning Aisi D2 Hardened Steel in Continuous and Interrupted Cutting
Authors: Dias Ernane Felipe , Barroso Caio Cesar Gonçalves Coutinho , Santos Sandro Cardoso 
Published: March 2024

Abstract

Important technological advances in the mechanical manufacturing industry have increasingly generated good results with the turning of hardened materials, using polycrystalline cubic boron nitride (PCBN) tools, mainly replacing abrasive processes. Tool steels play varied and essential roles in various industrial applications, such as dies and punches for forming and cutting. This work involves the evaluation the performance of a PCBN tool in turning quenched and tempered AISI D2 steel, both in continuous cutting and interrupted cutting conditions, in the finishing operation with dry machining. The surface roughness was evaluated in the parameters (Ra, Rt and Rz), the wear suffered by the tools, their mechanisms and morphological analysis of the chips. Tests were carried out with different cutting speeds (60, 130, 200 and 240 m/min), maintaining a constant feed rate of 0.15 mm/rev and a cutting depth of 0.2 mm. The results indicated that the most evident wear was crater and flank in the continuous cut, while in the interrupted cut there was the presence of chipping and catastrophic failure. Wear mechanisms, such as adhesion (attrition), abrasion and diffusion were prominently observed. Furthermore, the tests showed that the increase in flank wear did not necessarily result in an increase in surface roughness, and that the wear mechanism changed with the increase in cutting speed. In the continuous cutting condition, the tool achieved more satisfactory performance, especially at higher cutting speeds (130, 200 and 240 m/min). In interrupted cutting, there is a predominance of catastrophic failure mainly in the ranges of 60 and 130 m/min and better performance at 200 m/min within the ranges evaluated.
The Lip Split: A Retrospective Outcomes Study and Case Series following Central and Lateral Lip Split Access for Head and Neck Reconstructive Surgery
Authors: Gearing Peter , Devine Maxim , Pang Siyuan , Sim Felix , Ramakrishnan Anand 
Published: March 2024

Abstract
Purpose:
Surgical resection of oral cancers requires meticulous planning to achieve clear margins and minimize potential morbidity. This study aimed to compare postoperative surgical and functional outcomes following central and lateral lip-split approaches used for resection and reconstruction of oral tumours.
Methods:
A retrospective review of 79 cases involving lip-split procedures for head and neck cancers was conducted. Data were collected from a prospectively recorded database (December 2015 to December 2022). Statistical analyses compared patient demographics, intraoperative characteristics, and postoperative outcomes between central and lateral lip-split cohorts.
Results:
Lateral lip splits were associated with higher rates of postoperative complications (p = 0.008), including return to theatre (p = 0.015), and functional issues including asymmetric smile (p = 0.009). No significant differences were observed in readmission rates, length of stay, or time to oral diet commencement (p > 0.05). Six cases were selected to highlight the potential advantages and disadvantages of central and lateral lip split procedures.
Conclusions:
Lip-split procedures remain valuable for resection and reconstruction of oral and oropharyngeal tumours. Lateral lip splits are associated with poorer outcomes when compared to central approaches. Appropriate selection of lip splitting approaches should consider tumour location, resection margins, patient comorbidities and preferences, and surgical preferences.
Higher-order adaptive BFGS algorithm for nonconvex functions
Authors: Li Xiangli , Li Binglan , Wang Zhiling 
Published: March 2024

Abstract

Quasi-Newton methods are commonly used to solve unconstrained optimization problems, among which BFGS method is one of the most common quasi-Newton method, which has stable and good performance.Whether BFGS method has global convergence or not under weak Wolfe-Powell (WWP) line search is a widely concerned issue in recent years. BFGS method can be easily proved to have global convergence for convex functions, but not for general nonconvex functions. Therefore we propose an modified BFGS algorithm with global convergence, and the following properties are shown in this algorithm:(i) a special descent condition is proposed to classify the iteration points into two categories; (ii) we construct a new paraboloid and the corresponding projection technique by utilizing the information of the third-order expansion of the function; (iii) for the points satisfying the special descent conditions, the original BFGS update formula is used; (iv) for points that do not satisfy the conditions, they are projected onto the proposed paraboloid.Our new improved BFGS algorithm has global convergence under WWP search and also has good numerical performance.
ECG Captioning with Prior-Knowledge
Transformer and Diffusion Probabilistic Model
Authors: Tran Thi Diem , Tran Ngoc Quoc , Dang Thi Thu Khiet , Pham Hoai Luan , Nakashima Yasuhiko 
Published: March 2024

Abstract

Deep learning-based ECG interpretation has recently surfaced as a promising technique in automating report generation to reduce time and expense at the clinic. However, ECG descriptions generated by previous methods show considerable limitations compared with the diagnosis from cardiologists. This research proposes a deep network for extracting features by concatenating two networks: 1D input signal and 2D input spectrogram. Conjoining characteristics 1D and 2D push the captioning network based on the Transformer, focusing on complicated ECG components such as the P and T waves. Besides, we propose a novel approach for the prior knowledge module that utilizes the CO-attention Siamese Network to increase accuracy and performance to comprehend unique ECG characteristics. We also suggest an efficient augmentation technique to reduce the data imbalance and the FNet module to optimize the attention blocks in the Transformer design. The performance is validated using the PhysioNet Challenge 2021 database with approximately 88,243 twelve-lead ECG recordings. We train the model on free-text annotations of ECGs; the BLEU1, BLEU2, BLEU3, BLEU4, METEOR, ROUGE, and CIDEr scores are 0.88, 0.87, 0.81, 0.79, 0.62, 0.88, and 8.35, respectively, compared our output with generated captions based on the clinic standard. Using the public China Physiological Signal Challenge dataset, our proposal outperforms the earlier efforts for classification problems on the Sinus, First-degree atrioventricular block, and PVC rhythms. This study shows that a deep neural network appropriately trained on unstructured free-text physician annotations might lessen cardiologists' clinical workload when interpreting cardiovascular illness for patients. According to the concept, captioning ECG reports via a deep neural network may assist clinicians in evaluating ECG and reducing clinical workload.