bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclic Loading of Rotator Cuff Reconstructions
Authors: Lorbach Olaf , Bachelier Felix , Vees Jochen , Kohn Dieter , Pape Dietrich 
Published: February 2008

Background Double-row repair is suggested to have superior biomechanical properties in rotator cuff reconstruction compared with single-row repair. However, double-row rotator cuff repair is frequently compared with simple suture repair and not with modified suture configurations. Hypothesis Single-row rotator cuff repairs with modified suture configurations have similar failure loads and gap formations as double-row reconstructions. Study Design Controlled laboratory study. Methods We created 1 × 2-cm defects in 48 porcine infraspinatus tendons. Reconstructions were then performed with 4 single-row repairs and 2 double-row repairs. The single-row repairs included transosseous simple sutures; double-loaded corkscrew anchors in either a double mattress or modified Mason-Allen suture repair; and the Magnum Knotless Fixation Implant with an inclined mattress. Double-row repairs were either with Bio-Corkscrew FT using modified Mason-Allen stitches or a combination of Bio-Corkscrew FT and PushLock anchors using the SutureBridge Technique. During cyclic load (10 N to 60-200 N), gap formation was measured, and finally, ultimate load to failure and type of failure were recorded. Results Double-row double-corkscrew anchor fixation had the highest ultimate tensile strength (398 ± 98 N) compared to simple sutures (105 ± 21 N; P < .0001), single-row corkscrews using a modified Mason-Allen stitch (256 ± 73 N; P = .003) or double mattress repair (290 ± 56 N; P = .043), the Magnum Implant (163 ± 13 N; P < .0001), and double-row repair with PushLock and Bio-Corkscrew FT anchors (163 ± 59 N; P < .0001). Single-row double mattress repair was superior to transosseous sutures ( P < .0001), the Magnum Implant ( P = .009), and double-row repair with PushLock and Bio-Corkscrew FT anchors ( P = .009). Lowest gap formation was found for double-row double-corkscrew repair (3.1 ± 0.1 mm) compared to simple sutures (8.7 ± 0.2 mm; P < .0001), the Magnum Implant (6.2 ± 2.2 mm; P = .002), double-row repair with PushLock and Bio-Corkscrew FT anchors (5.9 ± 0.9 mm; P = .008), and corkscrews with modified Mason-Allen sutures (6.4 ± 1.3 mm; P = .001). Conclusion Double-row double-corkscrew anchor rotator cuff repair offered the highest failure load and smallest gap formation and provided the most secure fixation of all tested configurations. Double-loaded suture anchors using modified suture configurations achieved superior results in failure load and gap formation compared to simple suture repair and showed similar loads and gap formation with double-row repair using PushLock and Bio-Corkscrew FT anchors. Clinical Relevance Single-row repair with modified suture configurations may lead to results comparable to several double-row fixations. If double-row repair is used, modified stitches might further minimize gap formation and increase failure load.
IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis
Authors: Scheeren Ferenc A. , Diehl Sean A. , Smit Laura A. , Beaumont Tim , Naspetti Marianne , Bende Richard J. , Blom Bianca , Karube Kennosuke , Ohshima Koichi , van Noesel Carel J. M. , Spits Hergen 
Published: February 2008

AbstractClassical Hodgkin lymphoma (HL) is a malignant disorder characterized by the presence of neoplastic mononucleated Hodgkin and multinucleated Reed-Sternberg cells. Here, we show that both the interleukin (IL)–21 receptor as well as IL-21 are expressed by HL cells. IL-21 activates signal transducer of activation and transcription 3 (STAT3) and STAT5 in HL cell lines and activated human B cells. Ectopic expression of constitutively active STAT5 in primary human B cells resulted in immortalized B cells that have lost the B-cell phenotype and strongly resembled HL cells, which could partially be rescued by ectopic expression of the B cell–determining transcription factor E47. Data from experiments using reporter assays and overexpression of constitutively active IKK2 support the hypothesis that the STAT5 and nuclear factor-κB (NF-κB) pathways colaborate in HL genesis.
Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses
Authors: Groot Fedde , Welsch Sonja , Sattentau Quentin J. 
Published: February 2008

Abstract
Macrophages are reservoirs of HIV-1 infection, proposed to transmit virus to CD4+ T cells, the primary target of the virus. Here we report that human monocyte-derived macrophages (MDMs) rapidly spread HIV-1 to autologous CD4+ T cells resulting in productive infection. Transmission takes place across transient adhesive contacts between T cells and MDMs, which have the features of a virological synapse including copolarization of CD4 on the T cell with HIV-1 Gag and Env on the macrophage. We propose that an infected MDM can infect at least one T cell every 6 hours. Since HIV-1–infected macrophages can survive for many weeks, these results highlight the central role played by macrophages in HIV-1 infection and pathogenesis.
Dissecting microregulation of a master regulatory network
Authors: Sinha Amit U , Kaimal Vivek , Chen Jing , Jegga Anil G 
Published: February 2008

AbstractBackgroundThe master regulator p53 tumor-suppressor protein through coordination of several downstream target genes and upstream transcription factors controls many pathways important for tumor suppression. While it has been reported that some of the p53's functions are microRNA-mediated, it is not known as to how many other microRNAs might contribute to the p53-mediated tumorigenesis.ResultsHere, we use bioinformatics-based integrative approach to identify and prioritize putative p53-regulated miRNAs, and unravel the miRNA-based microregulation of the p53 master regulatory network. Specifically, we identify putative microRNA regulators of a) transcription factors that are upstream or downstream to p53 and b) p53 interactants. The putativep53-miRsand their targets are prioritized using current knowledge of cancer biology and literature-reported cancer-miRNAs.ConclusionOur predicted p53-miRNA-gene networks strongly suggest that coordinated transcriptional andp53-miRmediated networks could be integral to tumorigenesis and the underlying processes and pathways.
Extra-gastrointestinal stromal tumor of the greater omentum: report of a case and review of the literature
Authors: Franzini Christian , Alessandri Luciano , Piscioli Irene , Donato Salvatore , Faraci Rosario , Morelli Luca , Del Nonno Franca , Licci Stefano 
Published: February 2008

Abstract

Background
Gastrointestinal stromal tumors (GISTs) represent the majority of primary non-epithelial neoplasms of the digestive tract, most frequently expressing the KIT protein detected by the immunohistochemical staining for the CD117 antigen. Extra-gastrointestinal stromal tumors (EGISTs) are neoplasms with overlapping immunohistological features, occurring in the abdomen outside the gastrointestinal tract with no connection to the gastric or intestinal wall.

Case presentation
We here report the clinical, macroscopic and immunohistological features of an EGIST arising in the greater omentum of a 74-year-old man, with a discussion on the clinical behavior and the prognostic factors of such lesions and a comparison with the gastrointestinal counterpart.

Conclusion
The EGISTs in the greater omentum can grow slowly in the abdomen for a long time without clinical appearance. In most cases a preoperative diagnosis is not possible, and the patient undergoes a surgical operation for the generic diagnosis of "abdominal mass". During the intervention it is important to achieve a complete removal of the mass and to examine every possible adhesion with the gastrointestinal wall. Yamamoto's criteria based on the evaluation of the mitotic rate and the MIB-1 labelling index seems to be useful in predicting the risk for recurrence or metastasis. More studies are necessary to establish the prognostic factors related to localization and size of the EGIST and to evaluate the impact of the molecular characterization as an outcome parameter related to the molecular targeted therapy. In absence of these data, an accurate follow-up is recommended.
A technique for computed tomography (CT) of the foot in the standing horse
Authors: Desbrosse F. G. , Vandeweerd J.‐M. E. F. , Perrin R. A. R. , Clegg P. D. , Launois M. T. , Brogniez L. , Gehin S. P. 
Published: February 2008

SummaryComputed tomography (CT) in equine orthopaedics is currently limited because of the price, availability, impossibility to transport the scanner into surgical theatre, and the contraindications of general anaesthesia in some patients. A pQCT (peripheral quantitative computerised tomography) scanner was designed by the authors to image the limbs of the horse, both in standing or recumbent position. Standing computed tomography of the foot with a pQCT scanner is feasible and well tolerated by the horse. It enables good visualisation of bony structures but is not suitable to evaluate soft tissues. The technique can also assist surgery by assessing the 3D configuration of bone lesions.
Ultrasonographic guided injection of the scapulohumeral joint in horses
Authors: Carnicer D. , Coudry V. , Denoix J.‐M. 
Published: February 2008

SummaryIntra‐articular injections of the scapulohumeral joint (SHJ) in horses are difficult to perform because of the thick muscles covering the area and a reduced articular space. Ultrasonographic guidance was demonstrated to be helpful to perform intra‐articular injections. This technique applied to the SHJ can be performed in the field with a portable machine.The joint space is firstly imaged in transverse and proximodistal scans. After aseptic preparation of the shoulder area, the probe is placed to image the SHJ space in transverse section and the needle is inserted cranially in the ultrasound beam. The progression of the needle is followed towards the SHJ space, limiting joint injuries and side effects.
The use of intraluminal stents for tracheal collapse in two horses: Case management and long‐term treatment
Authors: Wong D. M. , Sponseller B. A. , Riedesel E. A. , Couëtil L. L. , Kersh K. 
Published: February 2008

SummaryTracheal collapse is an uncommon clinical disorder in horses but when present can be difficult to correct. Various medical and surgical procedures to correct tracheal collapse have been described in horses with variable success. Recently, the use of an intraluminal stent has been described as a treatment for tracheal collapse in a miniature horse. The long‐term management, utilising intraluminal stents, in 2 miniature horses with tracheal collapse is presented here. In particular, various complications as a result of intraluminal stent placement are described, the most persistent being the formation of granulation tissue at various regions of the stents. Multiple methods of combating granulation tissue in this situation also are discussed.
Fracture of the ischium in an eight‐year‐old Arabian gelding: A diagnostic challenge
Authors: Driver A. J. , Nagy A. 
Published: February 2008

SummaryProximal hindlimb lameness remains a diagnostic challenge despite modern imaging techniques. In the case described here, a fracture of the ischium produced false negative results on initial ultrasound and scintigraphy examinations, despite a 14 day delay from onset of clinical signs to the time of the nuclear bone scan. However, the history and clinical examination were strongly suggestive of a pelvic injury and this was only confirmed by the use of a novel radiographic technique.False negative findings from diagnostic imaging can, and do, occur, even with high sensitivity techniques such as nuclear bone scans used after an appropriate delay period. Therefore, equal weighting should be given to all facets of a lameness investigation, including the history and clinical examination, while remembering the limitations of any imaging modalities used.
Binary Regression with Misclassified Response and Covariate Subject to Measurement Error: a Bayesian Approach
Authors: McGlothlin Anna , Stamey James D. , Seaman John W. 
Published: February 2008

AbstractWe consider a Bayesian analysis for modeling a binary response that is subject to misclassification. Additionally, an explanatory variable is assumed to be unobservable, but measurements are available on its surrogate. A binary regression model is developed to incorporate the measurement error in the covariate as well as the misclassification in the response. Unlike existing methods, no model parameters need be assumed known. Markov chain Monte Carlo methods are utilized to perform the necessary computations. The methods developed are illustrated using atomic bomb survival data. A simulation experiment explores advantages of the approach. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Monomeric Cu(II) Complex Containing Chiral Phase‐transfer Catalyst as Ligand and Its Asymmetrically Catalytic Reaction
Authors: QU Zhi‐Rong , XIONG Ren‐Gen 
Published: February 2008

AbstractThe thermal treatment of CuCl2 with N‐(4′‐vinylbenzyl)cinchonidinium chloride (L1) afforded a monomeric discrete homochiral copper(II) complex N‐4′‐(vinylbenzyl)cinchonidinium trichlorocoprate(II) (1). Their applications to the enantioselectively catalytic alkylation reaction of N‐(diphenylmethylidene)glycine tert‐butyl ester (3) show that the higher ee value observed in catalyst 1 than that in the corresponding free ligand L1 is probably due to the rigidity enhancement after the coordination of N atom of quinoline ring to the copper ion.
Phase Equilibria and Plate‐fluid Interfacial Tensions for Four‐site Associating Lennard‐Jones Fluids Confined in Slit Pores
Authors: FU Dong , YAN Shu‐Mei , WANG Xue‐Min 
Published: February 2008

AbstractThe excess Helmholtz free energy functional for four‐site associating Lennard‐Jones (LJ) fluid was formulated in terms of a modified fundamental measure theory for short‐ranged interactions and a first‐order mean‐spherical approximation theory for long‐ranged attraction. Within the framework of density functional theory, the thermodynamic properties including the average density isotherms, density profiles and fractions of not bonded monomers characterizing the coexistences between gas‐like and liquid‐like phases for capillary condensation, phase equilibria and equilibrium plate‐fluid interfacial tensions were investigated. The influences of association energy, fluid‐solid interaction and pore width on the inhomogeneous behavior of four‐site associating LJ fluids confined in slit pores were discussed.
Sodium Hydrogen Sulfate as Effective and Reusable Heterogeneous Catalyst for the One‐pot Preparation of 14H‐[(Un)substituted phenyl]‐dibenzo[a,j]xanthene Leuco‐dye Derivatives
Authors: SHATERIAN Hamid Reza , DOOSTMOHAMMADI Razieh , GHASHANG Majid 
Published: February 2008

AbstractNaHSO4·H2O has been used as an efficient catalyst for the one‐pot preparation of 14H‐[(un)substituted phenyl]‐dibenzo[a,j]xanthene leuco‐dye derivatives by condensation of β‐naphthol with substituted benzaldehydes under microwave and thermal conditions. This method has the advantages of high yields, a green reaction, an efficient and cost‐effective method, simple procedures, short reaction time, and easy workup.
A collocated, iterative fractional‐step method for incompressible large eddy simulation
Authors: Jothiprasad Giridhar , Caughey David A. 
Published: February 2008

AbstractFractional‐step methods are commonly used for the time‐accurate solution of incompressible Navier–Stokes (NS) equations. In this paper, a popular fractional‐step method that uses pressure corrections in the projection step and its iterative variants are investigated using block‐matrix analysis and an improved algorithm with reduced computational cost is developed. Since the governing equations for large eddy simulation (LES) using linear eddy‐viscosity‐based sub‐grid models are similar in form to the incompressible NS equations, the improved algorithm is implemented in a parallel LES solver. A collocated grid layout is preferred for ease of extension to curvilinear grids. The analyzed fractional‐step methods are viewed as an iterative approximation to a temporally second‐order discretization. At each iteration, a linear system that has an easier block‐LU decomposition compared with the original system is inverted. In order to improve the numerical efficiency and parallel performance, modified ADI sub‐iterations are used in the velocity step of each iteration. Block‐matrix analysis is first used to determine the number of iterations required to reduce the iterative error to the discretization error of$O\left(\Delta t^2\right)$. Next, the computational cost is reduced through the use of a reduced stencil for the pressure Poisson equation (PPE). Energy‐conserving, spatially fourth‐order discretizations result in a 7‐point stencil in each direction for the PPE. A smaller 5‐point stencil is achieved by using a second‐order spatial discretization for the pressure gradient operator correcting the volume fluxes. This is shown not to reduce the spatial accuracy of the scheme, and a fourth‐order continuity equation is still satisfied to machine precision. The above results are verified in three flow problems including LES of a temporal mixing layer. Copyright © 2008 John Wiley & Sons, Ltd.
Geomorphologic land classification map of the Mekong Delta utilizing JERS‐1 SAR images
Authors: Haruyama Shigeko , Shida Ken 
Published: February 2008

AbstractFlood damage in the Mekong Delta is currently influenced by population growth and the expansion of farmland. The objectives of this study are to describe a method for visualizing flooded areas, classify the geomorphology of the area, and develop a flood‐risk map of the Mekong Delta using Japanese earth resources satellite‐1 synthetic aperture radar (JERS‐1 SAR) data. JERS‐1 SAR data‐processing involves geo‐referencing, image‐noise reduction, re‐sampling, and calculation of the normalized radar cross‐section (NRCS) using TNTmips. Furthermore, we visualized the flooded area of the Mekong River Delta and discussed flood dynamics. The relation between NRCS and micro‐geomorphology was clarified using the geomorphologic land classification map. After evaluating flood risk, we developed a flood‐risk map to visualize the evaluated risk. The differences in NRCS derived from JERS‐1 SAR data were calculated before and after flooding; visualization of the flooded area revealed that the difference between the two datasets was less than − 1·8 (dB). This value was determined from field investigations. We then compiled a map of the flooded area. The relation between NRCS and geomorphology was clarified based on the geomorphologic land classification map. Copyright © 2008 John Wiley & Sons, Ltd.
Experimental analysis of preschool playmate preferences as a function of smiles and sex
Authors: Schultz David , Ambike Archana , Buckingham‐Howes Stacy , Cheah Charissa S. L. 
Published: February 2008

AbstractDifferential emotions theory (DET) (The face of emotion. Appleton‐Century‐Crofts: East Norwalk, CT, 1971) posits that the smile functions in part to communicate and/or reflect social affiliation and plays an important role in children's social development. While children's positive emotion expressions have received attention from peer relations researchers in observational studies and within correlational designs, there is almost no experimental evidence for the impact of the smile. Building on existing studies, the present study examined DET predictions within an experimental design. More specifically, we examined the impact smiles have on lower‐income preschool children's nominations for preferred playmates. Both boys and girls tended to nominate unfamiliar playmates who smiled. Additionally, some evidence suggested that preference for smiling playmates seemed more critical to girls' than boys' social functioning. Unlike among boys, teachers rated girls who exhibited a greater preference for smiling playmates as higher in social competence. Copyright © 2008 John Wiley & Sons, Ltd.
Synthesis of herbicidal ZJ0273 labeled with tritium and carbon‐14
Authors: Yang Zheng‐Min , Ye Qing‐Fu , Lu Long 
Published: February 2008

AbstractZJ0273, propyl 4‐(2‐(4,6‐dimethoxypyrimidin‐2‐yloxy)benzylamino)benzoate, is a broad‐spectrum herbicidal ingredient used for weed control in oilseed rape in China. Two mono‐labeled ZJ0273, propyl 4‐(2‐(4,6‐dimethoxypyrimidin‐2‐yloxy)[phenyl‐3,4,5,6‐3H4]benzylamino)benzoate (7) and propyl 4‐(2‐(4,6‐dimethoxy[4,6‐14C2]pyrimidin‐2‐yloxy)benzylamino)benzoate (12), were synthesized separately from [2,3,4,5,6‐3H5]phenol in a four‐step yield of 27% and from 4,6‐dichloro‐2‐(methylthio)[4,6‐14C2]pyrimidine in a three‐step yield of 54%. In addition, two dual‐labeled analogues of ZJ0273 were prepared by homogeneously mixing tritium‐labeled ZJ0273 (7) in the benzyl ring separately with two carbon‐14‐labeled ZJ0273 (2, 12) in the benzoate ring and the pyrimidine ring. These labeled ZJ0273 could be used as radiotracers in the studies on the metabolism, mode of action, environmental behavior, and fate of ZJ0273. Copyright © 2008 John Wiley & Sons, Ltd.
Immunomodulatory activity of shikimic acid and quercitin in comparison with oseltamivir (Tamiflu) in an “in vitro” model
Authors: Bertelli A.A.E. , Mannari C. , Santi S. , Filippi C. , Migliori M. , Giovannini L. 
Published: February 2008

AbstractThe risk of an avian influenza pandemic has put oseltamivir (Tamiflu®) in the spotlight and has given rise to rumors that shikimic acid (SK), which is used for the synthesis of Tamiflu®, possesses therapeutic activity. This study was undertaken to determine whether SK, either alone or in combination with quercitin (QT) is able to modulate the release of IL‐6 and IL‐8 from peripheral blood mononuclear cells (PBMCs). The experiments were conducted comparing the properties of SK, both alone and in combination, with those of Tamiflu®. The incubation of PBMCs with 100 nM Tamiflu® or SK at two concentrations (10 nM; 100 nM) did not produce any change in IL‐6 and IL‐8 baseline levels (data expressed as incremental change vs. baseline). On the contrary, incubation with SK and QT at both concentrations (10 and 100 nM) produced a significant increase in the release of IL‐8 as compared to other groups (4.19 ± 0.82, SK‐QT 10 nM; 3.83 ± 1.17 SK‐QT 100 nM, P < 0.05 vs. baseline 1.00 ± 0.10, Tamiflu® 100 nM 1.35 ± 0.16, SK 10 nM 1.68 ± 0.15 and SK 100 nM 1.80 ± 0.48). The SK‐QT combination also proved to be effective in the upregulation of IL‐6 (3.08 ± 0.46, SK‐QT 10 nM; 3.60 ± 0.74 SK‐QT 100 nM, P < 0.05 vs. baseline 1.00 ± 0.26). According to these findings SK alone is not able to modulate innate immunity in antiviral terms. However, the data show that the SK + QT combination, even at low doses, may be effective for the modulation of innate immunity. J. Med. Virol. 80:741–745, 2008. © 2008 Wiley‐Liss, Inc.