bluuebunny/crossref_metadata_2025_split huggingface dataset:
Opportunities for collaboration: the synergy between antimicrobial and diagnostic stewardship in pediatrics
Authors: Hoyt Brandy M. , Messacar Kevin , Sick-Samuels Anna C. , Jaggi Preeti , Hamilton Stacey L. , Janelle Sarah , Parker Sarah K. 
Published: February 2025

Abstract
Advancement of antimicrobial stewardship (AS) programs requires partnership with clinicians, quality assurance teams, and laboratorians. Inevitably, AS programs also practice diagnostic stewardship (DS), as stewards are aptly placed to connect key stakeholders and help steer processes toward higher value care for pediatric patients. In this review, we illustrate five moments of collaboration between stakeholders in the interplay between AS and DS in pediatrics. These moments include (1) Observation, (2) Reflection, (3) Exploration, (4) Enactment and (5) Evaluation. We offer a targeted narrative of examples in current literature using common relatable scenarios (ie, endotracheal aspirates, blood cultures, gastrointestinal samples, and urine testing) including impact on financial and environmental waste.
Why EU revenue matters: A case for an EU digital levy
Authors: Pantazatou Katerina 
Published: February 2025

Abstract
This Article draws upon and connects three different developments: the ‘internationalisation’ of tax law and EU tax law, specifically; the increasing digitalisation of the economy, and the European Union’s need for more revenue to deal with the financial consequences of the COVID-19 pandemic and other policy priorities. It is explained why the taxation of data per se cannot be addressed at the global level at present and why the focus of research has to lie on the taxation of the different business models of the digital economy. In the absence of a global agreement as to how the digital economy should be taxed, the reaction of the European Union to such a fundamental undertaking remains uncertain and politically contingent on the outcomes of negotiation at the OECD level. Most particularly, on the so-called Pillar One agreement. A seemingly temporal solution to the taxation of the digital economy, the so-called DSTs (Digital Services Taxes) have been adopted by Member States of the EU and third countries, but their future remains uncertain. Amidst these developments, the EU has also looked for ways to increase its resources and to finance its post-Covid ambitious recovery plan. This need has led to a reconsideration of whether EU taxes could finance the EU budget (next to the Union’s own resources, which remain for the main part transfers from Member States). In this Article, I argue that beyond tax design considerations and potential constitutional impediments, the EU revenue side should be emphasised in the discussion. Therefore, I suggest that the Union should ensure that at least part of the revenue arising from digital taxation should be channeled to the supranational budget. Whether Pillar One gets adopted or not, the potential introduction of an EU digital levy, ideally by way of an EU tax, could help overcoming several shortcomings of the present tax status quo and could result in an increase of the resources at the disposal of the EU in a fashion compatible with the imperatives of democratic legitimacy.
When turnips bleed: the racial duality of predatory ticket debt
Authors: Henricks Kasey , Ortiz Ruben 
Published: February 2025

Abstract
How do sociolegal scholars who liken monetary sanctions to “bleeding a turnip” or “drawing blood from stones” reconcile these idioms with the fact that fines and fees constitute a growth industry? We take up this puzzle by turning our attention to perhaps the most relatable experience with monetary sanctions among the population: parking tickets. Much of the available law and society literature on fines and fees documents how these sanctions disproportionately impact communities subjugated by race and class. Because parking tickets are adjudicated within a legal domain so fundamentally different from fines and fees that dominate the academic focus, we ask whether these insights extend outside criminal counts to municipal ones. Using Chicago as a case study, our inquiry measures the structural determinants of 11.3 million tickets issued between 2013 and 2017. We use a series of count models to predict the incidence rates of tickets at the tract level as well as how many were subject to reprimands for nonpayment. What we find are disparate patterns of racialization in terms of who is targeted by these sanctions versus who is devastated by them. We synthesize key ideas from empirical critical race theory and developing work on predation theory to make sense of these findings.
Évidentialité ou modalité épistémique? Le cas de sans doute, un marqueur évidentiel inférentiel qui peut paraître épistémico-modal
Authors: Dendale Patrick , Vanderheyden Anne 
Published: February 2025

Abstract
This article focuses on the problem of the categorization of the adverb sans doute as an epistemico-modal marker or an evidential marker. Starting from a critical appraisal of an analysis proposed by Bourmayan et Ashino, in which sans doute is considered fundamentally epistemico-modal, three hypotheses are presented, which depart from theirs. First, sans doute has as its main lexical element an inferential evidential value: it signals that the content qualified by the adverb is the result of a defeasible type of inference from clues/premises. Second, due to the defeasibility of the inference, the statement containing the adverb takes on, invariably, a pragmatic value of non-certainty, not lexically coded, however. Sans doute is thus not an epistemico-modal marker by itself in contemporary French. Third, the adverb combines these values with an epistemic value of what we call “posture of certainty”. Different from epistemic modality, which refers to an evaluation in terms of certainty, and/or to the epistemic cognitive state linked to that, posture of certainty refers to what can be called the tone or epistemic behavior of confidence the speaker shows. Sans doute therefore indicates without contradiction, a defeasible and, thus, uncertain hypothesis, presented with a tone of full confidence.
A survey of provinces in the Anglican Communion that have allowed same-sex blessings or same-sex marriages in church
Authors: Village Andrew 
Published: February 2025

Abstract
In October 2022, the Church of England commissioned a study of the likely impacts of allowing the blessing or marriage of same-sex couples in church. This paper reports on a survey of key informers (bishops or chief executive officers) in dioceses in the seven provinces of the Anglican Communion that had at that time allowed either same-sex blessings (SSB) or same-sex marriages (SSM). Of 183 provinces or dioceses contacted, 62 (31%) replied to an online survey of which 74% had decided to allow SSB and 55% to allow SSM. While all provinces reported some losses of clergy or congregations, these were not as great as some had expected. Smaller provinces that had made spaces and time for those of differing opinions to meet together tended to report more positive outcomes than those where processes were dominated by synodical debates.
Quantitative analysis using two scales of internal (church-facing) and external (society-facing) impact showed that dioceses that allowed SSM rather than just SSB reported more positive external impact. Those that had allowed SSM reported better internal and external impact compared with those who allowed only SSB or neither. Open answers offered critical reflections highlighting important lessons learnt in the process of making decisions.
Analog parallel processor for broadband multifunctional integrated system based on silicon photonic platform
Authors: Qian Na , Zhou Defu , Shu Haowen , Zhang Ming , Wang Xingjun , Dai Daoxin , Deng Xiao , Zou Weiwen 
Published: February 2025

Abstract
Sharing the hardware platform between diverse information systems to establish full cooperation among different functionalities has attracted substantial attention. However, broadband multifunctional integrated systems with large operating frequency ranges are challenging due to the bandwidth and computing speed restrictions of electronic circuitry. Here, we report an analog parallel processor (APP) based on the silicon photonic platform that directly discretizes and parallelizes the broadband signal in the analog domain. The APP first discretizes the signal with the optical frequency comb and then adopts optical dynamic phase interference to reassign the analog signal into 2N parallel sequences. Via photonic analog parallelism, data rate and data volume in each sequence are simultaneously compressed, which mitigates the requirement on each parallel computing core. Moreover, the fusion of the outputs from each computing core is equivalent to directly processing broadband signals. In the proof-of-concept experiment, two-channel analog parallel processing of broadband radar signals and high-speed communication signals is implemented on the single photonic integrated circuit. The bandwidth of broadband radar signal is 6 GHz and the range resolution of 2.69 cm is achieved. The wireless communication rate of 8 Gbit/s is also validated. Breaking the bandwidth and speed limitations of the single-computing core along with further exploring the multichannel potential of this architecture, we anticipate that the proposed APP will accelerate the development of powerful opto-electronic processors as critical support for applications such as satellite networks and intelligent driving.
Microscale insight into the proton concentration during electrolytic reaction via an optical microfiber: potential for microcurrent monitoring by a dielectric probe
Authors: Huang Yunyun , Liang Jiaxuan , Wu Haotian , Chen Pengwei , Xiao Aoxiang , Guan Bai-Ou 
Published: February 2025

Abstract
Local microcurrent monitoring is of great significance for biological and battery systems, yet it poses a formidable challenge. The current measurement techniques rely on electromagnetic materials which inevitably introduce interference to the system under examination. To address this issue, a promising approach based on a dielectric fiber-optic sensor is demonstrated. The microfiber is capable of detecting microcurrent through monitoring the localized proton concentration signal with a pH resolution of 0.0052 pH units. By sensing the refractive index variation surrounding the sensor induced by the interaction between local proton concentration changes and oxidizer-treated microfiber surface through the evanescent field, this sensing mechanism effectively avoids the interference of the electromagnetic material on the performance of the tested system. This sensor exhibits a limit of detection for microcurrent of 1 μA. The sensing region is a microfiber with a diameter of 8.8 μm. It can get invaluable information that cannot be obtained through conventional electrochemical methods. Examples include photocurrent attenuation in photogenerated carrier materials during illumination, electrical activation in nerve cells, and fluctuations in the efficiency of electrical energy generation during battery discharge. This approach provides a powerful complement to electrochemical methods for the elucidation of microscale reaction mechanisms. The information provided by the prepared dielectric fiber-optic sensor will shed more light on proton kinetics and electrochemical and electrobiological mechanisms, which may fill an important gap in the current bioelectricity and battery monitoring methods.
Visuospatial outcomes of a prospective national cohort of young adults with very low birthweight
Authors: Harris Sarah L. , Woodward Lianne J. , Horwood L. John , Melzer Tracy R. , Bora Samudragupta , Pascoe Maddie , Darlow Brian A. 
Published: February 2025

Abstract

Background
Visuospatial processing is reportedly impaired in children born very preterm (VP) compared with full term (FT) controls but there are few data for VP adults.

Methods
At 26-30 years, 225 very low birthweight (VLBW) adults (70% national cohort survivors) and 100 FT controls were assessed on motor-dependent visuospatial skills using the Block Design subtest of the Wechsler Adult Intelligence Scale, and nonmotor-dependent skills by the Benton Judgment of Line Orientation and Brixton Spatial Anticipation tests. A composite score was created by summing standardized scores for the three tests. MRI measures of cortical volume, thickness and surface area were obtained for 150 VLBW participants.

Results
VLBW born adults performed less well than controls across all visuospatial measures and their composite score (P < 0.001), with moderate to large effect sizes (Cohen’s ds = 0.41–0.82). Between group differences were not explained by current vision impairment, cerebral palsy, sex, ethnicity or socio-demographic factors. The unadjusted visuospatial composite score was significantly correlated with reduced cortical surface area and cortical volume, but few correlations remained significant after adjustment for age, sex and intracranial volume.

Conclusion
The visuospatial functioning of adults born VLBW is significantly poorer than their FT peers with only modest associations with cortical brain structure.

Impact

Previous reports have shown very preterm children have impaired visuospatial processing compared with term-born peers but only limited data address whether these impairments persist into adulthood.

Visuospatial functioning, assessed by both motor and non-motor dependent tests, of adults born very low birthweight is significantly poorer than that of term-born peers.

Poorer visuospatial functioning in this very low birthweight cohort is not explained by vision impairment and had only modest associations with cranial MRI brain structure.

Persisting visuospatial impairment in very preterm adults may significantly impact quality of life. Early recognition of these difficulties could facilitate support strategies to improve outcomes.
Overcoming immunotherapy resistance in gastric cancer: insights into mechanisms and emerging strategies
Authors: Luo Dingtian , Zhou Jing , Ruan Shuiliang , Zhang Binzhong , Zhu Huali , Que Yangming , Ying Shijie , Li Xiaowen , Hu Yuanmin , Song Zhengwei 
Published: February 2025

Abstract
Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, with limited treatment options in advanced stages. Immunotherapy, particularly immune checkpoint inhibitors (ICIs) targeting PD1/PD-L1, has emerged as a promising therapeutic approach. However, a significant proportion of patients exhibit primary or acquired resistance, limiting the overall efficacy of immunotherapy. This review provides a comprehensive analysis of the mechanisms underlying immunotherapy resistance in GC, including the role of the tumor immune microenvironment, dynamic PD-L1 expression, compensatory activation of other immune checkpoints, and tumor genomic instability. Furthermore, the review explores GC-specific factors such as molecular subtypes, unique immune evasion mechanisms, and the impact of Helicobacter pylori infection. We also discuss emerging strategies to overcome resistance, including combination therapies, novel immunotherapeutic approaches, and personalized treatment strategies based on tumor genomics and the immune microenvironment. By highlighting these key areas, this review aims to inform future research directions and clinical practice, ultimately improving outcomes for GC patients undergoing immunotherapy.
Structural basis of inhibition of human NaV1.8 by the tarantula venom peptide Protoxin-I
Authors: Neumann Bryan , McCarthy Stephen , Gonen Shane 
Published: February 2025

Abstract
Voltage-gated sodium channels (NaVs) selectively permit diffusion of sodium ions across the cell membrane and, in excitable cells, are responsible for propagating action potentials. One of the nine human NaV isoforms, NaV1.8, is a promising target for analgesics, and selective inhibitors are of interest as therapeutics. One such inhibitor, the gating-modifier peptide Protoxin-I derived from tarantula venom, blocks channel opening by shifting the activation voltage threshold to more depolarized potentials, but the structural basis for this inhibition has not previously been determined. Using monolayer graphene grids, we report the cryogenic electron microscopy structures of full-length human apo-NaV1.8 and the Protoxin-I-bound complex at 3.1 Å and 2.8 Å resolution, respectively. The apo structure shows an unexpected movement of the Domain I S4-S5 helix, and VSDI was unresolvable. We find that Protoxin-I binds to and displaces the VSDII S3-S4 linker, hindering translocation of the S4II helix during activation.
Nanobody-thioesterase chimeras to specifically target protein palmitoylation
Authors: Kuo Chien-Wen , Gök Caglar , Fulton Hannah , Dickson-Murray Eleanor , Adu Samuel , Gallen Emily K. , Mary Sheon , Robertson Alan D. , Jordan Fiona , Dunning Emma , Mullen William , Smith Godfrey L. , Fuller William 
Published: February 2025

Abstract
The complexity of the cellular proteome is massively expanded by a repertoire of chemically distinct reversible post-translational modifications (PTMs) that control protein localisation, interactions, and function. The temporal and spatial control of these PTMs is central to organism physiology, and mis-regulation of PTMs is a hallmark of many diseases. Here we present an approach to manipulate PTMs on target proteins using nanobodies fused to enzymes that control these PTMs. Anti-GFP nanobodies fused to thioesterases (which depalmitoylate protein cysteines) depalmitoylate GFP tagged substrates. A chemogenetic approach to enhance nanobody affinity for its target enables temporal control of target depalmitoylation. Using a thioesterase fused to a nanobody directed against the Ca(v)1.2 beta subunit we reduce palmitoylation of the Ca(v)1.2 alpha subunit, modifying the channel’s voltage dependence and arrhythmia susceptibility in stem cell derived cardiac myocytes. We conclude that nanobody enzyme chimeras represent an approach to specifically manipulate PTMs, with applications in both the laboratory and the clinic.
D-2-hydroxyglutarate impairs DNA repair through epigenetic reprogramming
Authors: Lang Fengchao , Kaur Karambir , Fu Haiqing , Zaheer Javeria , Ribeiro Diego Luis , Aladjem Mirit I. , Yang Chunzhang 
Published: February 2025

Abstract
Cancer-associated mutations in IDH are associated with multiple types of human malignancies, which exhibit distinctive metabolic reprogramming, production of oncometabolite D-2-HG, and shifted epigenetic landscape. IDH mutated malignancies are signatured with “BRCAness”, highlighted with the sensitivity to DNA repair inhibitors and genotoxic agents, although the underlying molecular mechanism remains elusive. In the present study, we demonstrate that D-2-HG impacts the chromatin conformation adjustments, which are associated with DNA repair process. Mechanistically, D-2-HG diminishes the chromatin interactions in the DNA damage regions via revoking CTCF binding. The hypermethylation of cytosine, resulting from the suppression of TET1 and TET2 activities by D-2-HG, contributes to the dissociation of CTCF from DNA damage regions. CTCF depletion leads to the disruption of chromatin organization around the DNA damage sites, which abolishes the recruitment of essential DNA damage repair proteins BRCA2 and RAD51, as well as impairs homologous repair in the IDH mutant cancer cells. These findings provide evidence that CTCF-mediated chromatin interactions play a key role in DNA damage repair proceedings. Oncometabolites jeopardize genome stability and DNA repair by affecting high-order chromatin structure.
Retention of locally injected human iPS cell-derived cardiomyocytes into the myocardium using hydrolyzed gelatin
Authors: Iida Jun , Kotani Kazuki , Murata Kozue , Hakamada Keisuke , Maihemuti Wusiman , Mandai Yoshinobu , Hiraoka Yosuke , Minatoya Kenji , Masumoto Hidetoshi 
Published: February 2025

Abstract
This study explored the impact of hydrolyzed gelatin (HG) concentration on the retention and therapeutic efficacy of human iPS cell-derived cardiomyocytes (hiPSC-CMs) when injected into the myocardium. The solubility of HG allows precise control over its concentration, influencing the distribution and leakage of injected solutions, which may affect therapeutic outcomes. Using both ex vivo and in vivo rat models, we investigated how varying HG concentrations affect the retention of solution and diffusion within the myocardium. In ex vivo static rat hearts, 10% HG minimized leakage but allowed significant diffusion. However, in pulsating in vivo hearts, 20% HG provided the best retention. In a rat myocardial infarction model, hiPSC-CMs suspended in 20% HG resulted in the highest cell retention. Echocardiogram showed a significant increase in the ejection fraction two weeks after transplantation compared to before transplantation. Additionally, cardiac magnetic resonance imaging (MRI) revealed that the ejection fraction was significantly higher than that of the sham group four weeks after transplantation. These findings suggest that optimizing HG concentration is crucial for enhancing the retention and therapeutic efficacy of hiPSC-CM transplants in treating heart disease.
Decoding substance use disorder severity from clinical notes using a large language model
Authors: Mahbub Maria , Dams Gregory M. , Srinivasan Sudarshan , Rizy Caitlin , Danciu Ioana , Trafton Jodie , Knight Kathryn 
Published: February 2025

Abstract
Substance use disorder (SUD) poses a major concern due to its detrimental effects on health and society. SUD identification and treatment depend on a variety of factors such as severity, co-determinants (e.g., withdrawal symptoms), and social determinants of health. Existing diagnostic coding systems used by insurance providers, like the International Classification of Diseases (ICD-10), lack granularity for certain diagnoses, but American clinicians will add this granularity (as that found within the Diagnostic and Statistical Manual of Mental Disorders classification or DSM-5) as supplemental unstructured text in clinical notes. Traditional natural language processing (NLP) methods face limitations in accurately parsing such diverse clinical language. Large language models (LLMs) offer promise in overcoming these challenges by adapting to diverse language patterns. This study investigates the application of LLMs for extracting severity-related information for various SUD diagnoses from clinical notes. We propose a workflow employing zero-shot learning of LLMs with carefully crafted prompts and post-processing techniques. Through experimentation with Flan-T5, an open-source LLM, we demonstrate its superior recall compared to the rule-based approach. Focusing on 11 categories of SUD diagnoses, we show the effectiveness of LLMs in extracting severity information, contributing to improved risk assessment and treatment planning for SUD patients.