bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visual Outcomes following implantation of a non-diffractive extended depth of focus Intraocular Lens in patients with early dry macular degeneration
Authors: Vasavada Shail , Shastri Lajja , Nath Vandana , Dwivedi Shyamal , Patel Asav , Vasavada Vaishali , Srivastava Samaresh , Vasavada Abhay R. 
Published: February 2025

Purpose:
Evaluate visual outcomes following implantation of a non-diffractive extended deapth of focus (EDOF) intraocular lens (IOL) in patients with early dry age-related macular degeneration (AMD)

Setting:
Iladevi Cataract & IOL Research Centre, Ahmedabad, India

Design:
Prospective, interventional series

Methods:
Patients undergoing cataract surgery with the EDOF Acrysof Vivity IOL and having early dry AMD were included. Primary outcome measures were monocular unaided and corrected distance visual acuity (UDVA, CDVA) 3 months postoperatively. Secondary outcome measures were: monocular unaided and distance corrected intermediate (UIVA, DCIVA) (66cm) and near (UNVA, DCNVA) (40cm) visual acuity as well as mesopic contrast sensitivity (CS).

Results:
40 eyes (40 patients) with a mean age of 68.5 + 8.38 (standard deviation, SD) years were included. UDVA and CDVA at 3 months follow up were 0.12 + 0.07 and 0.10 + 0.10 (SD) LogMAR. UIVA, DCIVA were 0.25 + 0.09, 0.12 + 0.09 LogMAR. UNVA, DCNVA were 0.23 + 0.10, 0.19 + 0.15 LogMAR. Mesopic CS values without glare were 1.50 + 0.10, 1.69 + 0.26, 1.40 + 0.30 and 0.84 + 0.5 units at 3, 6, 12 and 18 cycles per degree (CPD). Mesopic CS with glare was 1.53 + 0.16, 1.63 + 0.21, 1.21 + 0.45 and 0.75 + 0.42 units.

Conclusion:
The Acrysof Vivity IOL gives very good distance visual acuity with improved intermediate and near visual acuity without significant compromise in contrast sensitivity in eyes with early dry AMD.
Clinical evaluation of the effectiveness of asymmetric intrastromal corneal ring segments with progressive base width for management of keratoconus.
Authors: HAYS Quentin , KALLEL Sofiene , GARCIN Thibaud , DAVID Clémentine , BARUGEL Raphaël , BORDERIE Marie , CUYAUBÈRE Roxane , GOEMAERE Isabelle , BORDERIE Vincent , BOUHERAOUA Nacim 
Published: February 2025

Purpose:
To evaluate visual, refractive, corneal topographic, and aberrometric results of asymmetric intracorneal ring segments (AS ICRS) with variable width to manage asymmetric keratoconus.

Setting:
Quinze-Vingts National Ophthalmology Hospital, Paris, France.

Design:
Prospective observational study.

Methods:
According to their tomographic pattern, patients receiving one AS ICRS (INTRASEG asymmetric; Gamma Vision) were included. AS INTRASEG features an arc length of 150 degrees and asymmetric width (800 to 1200 µm). Anterior segment optical coherence tomography (AS-OCT) combined with Placido disc MS-39 (CSO, Firenze, Italy) were performed before, 1, and 6 months after surgery to assess keratometric, aberrometric outcomes, and epithelial remodeling. Refractive outcomes were also evaluated. Analysis of the correction profile according to the width of the base of the ICRS was performed.

Results:
43 keratoconic eyes were analyzed. Significant improvement of corrected distance visual acuity was observed (LogMAR): from 0.34 ± 0.23 to 0.08 ± 0.10 (p<0.001). The flattening effect was higher at the widest end than the narrowest end (-10.59D ± 2.59 versus -4.54D ± 1.30, p<0.001), contributing to reduce the Symmetry Index Front from 9.06 ± 4.02 to 2.21 ± 3.81. Total higher orders aberrations reduced from 2.13 ± 0.94 µm to 1.77 ± 0.59 µm (p<0.001) with a halving of the coma aberration from 1.84 ± 0.87 µm to 0.89 ± 0.50 µm (p<0.001).

Conclusion:
Implantation of AS INTRASEG in asymmetric keratoconus improves refractive, topographic, and aberrometric parameters. The progressive width of the base is efficient for reducing vertical asymmetry and higher-order aberrations of asymmetric keratoconus phenotype.
Impact of Postoperative Walking vs. Lying Down on IOL Rotation After Lens Surgery: A Prospective Comparative Study
Authors: Jandewerth Tyll , Kaiser Klemens Paul , Hemkeppler Eva , Lwowski Christoph , Kohnen Thomas 
Published: February 2025

Purpose:
To determine the intraocular lens (IOL) rotational stability depending on patient position in the first postoperative hour after femtosecond laser assisted cataract or refractive surgery with implantation of a non-toric IOL in the capsular bag.

Setting:
Department of Ophthalmology, Goethe-University, Frankfurt, Germany.

Design:
Prospective, randomized clinical trial.

Methods:
In this study, 38 eyes of 36 patients received femtosecond laser assisted phacoemulsification and implantation of a non-toric IOL in the capsular bag. Patients were randomized into two groups: patients laid down for one hour after surgery due to the clinical standard (LD group), patients walked around in the first postoperative hour (W group). No miotic eye drops were applied at the end of operation. A retroilluminated slit lamp picture was taken at the end of the operation (baseline), one hour and one day postoperative. Changes in IOL position were measured by an axis between two episcleral landmarks and the haptics of the IOL. Measurements were performed by an image processing application specified for medical and scientific purpose. If not normally distributed, the paired t-test was used. Otherwise, the Mann-Whitney-U-Test was used if data was not normally distributed.

Results:
IOL rotation in the first hour was 1.80° ± 1.80° in the LD group and 1.21° ± 2.11° in the W group (p=0.123). One day after operation, IOL position differed from the baseline measurement with 1.52° ± 1.89° in the LD group and 1.51° ± 1.69° in the W group (p=0.773).

Conclusion:
Early postoperative patient position does not seem to influence IOL rotational stability.
Late refractive change after cataract extraction and toric intraocular lens implantation
Authors: Roston Sydney , Kulenkamp J. Erik , Ahmed Abdurahman , Scheurer Ryan , Armbrust Karen R. 
Published: February 2025

Purpose:
To report rates of change and identify factors associated with late change in refractive outcome after toric intraocular lens (IOL) implantation.

Setting:
Single-site study at the Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA.

Design:
Retrospective cohort study.

Methods:
Study inclusion required uncomplicated posterior chamber Alcon SN6ATT toric IOL implantation from 2010 –2017 and refractions 1 month and 5 years after surgery. Exclusion criteria were sulcus IOL placement, subsequent intraocular or refractive surgery in the operative eye, and 5-year Snellen visual acuity of 20/60 or worse. Outcomes of interest were change in spherical equivalent and change in magnitude of the astigmatism vector between the postoperative month 1 and postoperative year 5 refractions. Refractive stability was defined as ≤0.5D change in spherical equivalent and ≤1D change in magnitude of the astigmatism vector. Predictive factors analyzed included age, sex, race, pseudoexfoliation (PXF) syndrome, axial length (AL), pre-operative keratometry measurements (∆K), IOL power, neodymium:yttrium-aluminum-garnet capsulotomy, and intravitreal injections.

Results:
Of the 320 eyes meeting study criteria, spherical equivalent was stable in 241 (75%) eyes, astigmatism was stable in 266 (83%) eyes, and 205 (64%) eyes met criteria for refractive stability with both measures. Multivariable regression analysis identified shorter AL (p=0.018) and larger ∆K (p=0.002) as significant predictors of change in refractive astigmatism and PXF syndrome (p=0.006) as a predictor of hyperopic shift >0.5D.

Conclusions:
A minority of eyes exhibit late refractive change after toric IOL implantation. AL, ∆K, and PXF syndrome are independent predictors of late refractive change.
Alternative Models of Cardiac Rehabilitation to Promote Secondary Prevention in Patients With Coronary Heart Disease After Percutaneous Coronary Intervention
Authors: Almoghairi Ahmed Mohammed , O'Brien Jane , Alshammari Mukhlid , Duff Jed 
Published: February 2025

Background
Although cardiac rehabilitation (CR) is an effective secondary prevention strategy, it remains underutilized worldwide. Barriers to accessibility and adherence to traditional hospital-based programs have led to the development of alternative models, such as home-based CR, to improve healthcare delivery and patient outcomes.

Objective
In this study, we aimed to map and synthesize evidence of effective home-based CR models for promoting secondary prevention in patients with coronary heart disease after percutaneous coronary intervention.

Methods
Following the Joanna Briggs Institute methodology, we conducted a scoping review across 7 databases: Cochrane, CINAHL, Scopus, MEDLINE, Embase, PubMed, and Web of Science, and gray literature sources. The search included primary English-language articles published in the last decade, with an update extending to October 2024. Reviewers independently assessed eligibility, and data extraction followed the Template for Intervention Description and Replication and PRISMA guidelines.

Results
Among the 3296 initially identified articles, 23 met the inclusion criteria. The identified home-based CR models varied in duration (6 weeks to 6 months) and used a range of technological tools, such as Internet platforms and telecommunication, for exercise supervision and patient communication. These programs include supplementary equipment and educational resources to enhance patient self-efficacy and cardiovascular disease awareness.

Conclusions
All identified home-based CR models showed positive patient outcomes, with high program enrollment and adherence to secondary prevention measures. Further research is needed to compare different home-based CR models and assess their feasibility in diverse settings.
Is Decreased Hip Flexibility a Risk Factor of Arm Injuries in Young Baseball Players? Systematic Review and Meta-Analysis
Authors: Ueda Yasuyuki , Taniguchi Masashi , Noda Taiga , Minaguchi Souta , Ichihashi Noriaki 
Published: February 2025

Objectives:
Although various kinematic parameters have been investigated as factors associated with shoulder and elbow injuries during pitching, the relationship between lower extremity flexibility and such injuries remains unclear. The objective of this meta-analysis was to examine the association between pitching injuries to the shoulder and elbow and lower extremity flexibility.

Designs:
A systematic review and meta-analysis.

Date sources:
A comprehensive meta-analysis was conducted using data extracted from five databases (MEDLINE, Web of Science, CENTRAL, Scopus, and PEDro) following the method of Minds. The inclusion criteria were studies focusing on throwing injuries in the shoulder and elbow, specifically related to baseball, and the investigation of motion in the lower extremities. Owing to the presence of cross-sectional and cohort studies, meta-analyses were conducted for each study type.

Main Results:
Meta-analyses were performed using data from 11 reports. The results revealed a significant difference in lead-side hip internal rotation for both cross-sectional (P = 0.04) and cohort studies (P = 0.02), indicating a reduced range of motion (ROM) in athletes with shoulder and elbow injuries. In addition, a significant difference was observed in the hip internal rotation of the trail leg in the cross-sectional study (P = 0.04), similar to that of the lead leg. However, no significant differences were found in hip external rotation or straight leg raising (SLR) between players with and without shoulder or elbow injuries.

Conclusions:
This meta-analysis highlights the common occurrence of limited internal hip rotation ROM in baseball players with shoulder or elbow injuries. However, these injuries were not found to be associated with hip external rotation or SLR.
Head Contact and Suspected Concussion Rates in University Basketball: Are Head Contact Penalties a Target for Prevention?
Authors: Fehr Christy J. , West Stephen W. , Hagel Brent E. , Goulet Claude , Emery Carolyn A. 
Published: February 2025

Objective:
To compare head contact (HC) and suspected concussion incidence rates (IRs) in male and female university basketball players and describe associated game event and court location.

Design:
Cross-sectional.

Setting:
Canadian basketball courts.

Participants:
Players from 5 male and 5 female 2019 to 2020 regular season basketball games.

Assessment of Risk Factors:
Prerecorded game footage was analyzed using Dartfish video analysis software to compare sexes.

Main Outcome Measures:
Poisson regression analysis was used to estimate IRs and incidence rate ratios (IRRs) for HCs and suspected concussions. Head contacts were classified as HC1 (direct, player-to-player) or HC2 (indirect, player-to-environment). Game event, court location, and penalization of HCs were reported.

Results:
Two hundred thirty HCs (88.7% HC1s, 11.3% HC2s) were observed. The HC1 IR was higher in male than female players (IRR, 1.55; 95% CI, 1.16–2.06). Most HCs occurred within the key. Shooting was the primary offensive game event for male and female players for receiving HC1s (24.6% and 20.0%, respectively). Defensively, HC1s occurred most frequently while guarding an attacker for male players (40.6%) and rebounding for female players (31.0%). The suspected concussion IR was not significantly different between male and female players (IRR, 2.00; 95% CI, 0.20–19.8). In total, 11.2% of HC1s to defenders and 25.7% of HC1s to offensive players were assessed as a foul.

Conclusion:
Head contact rates were higher for male varsity basketball players compared with female players; however, suspected concussion rates did not differ. Game event and court locations differed by sex. A priority target for injury prevention is penalization of HCs because most HCs in competition went unpenalized.
Update on neonatal and infantile onset epilepsies
Authors: Carapancea Evelina , Sands Tristan T. , Cilio Maria Roberta 
Published: February 2025

Purpose of review
Neonatal and infantile epilepsies represent a diverse group of disorders with significant neurodevelopmental impact, necessitating early diagnosis, and tailored treatment. Recent advancements in genetic research, phenotyping, and therapeutic development have reshaped the understanding and management of these conditions, making this review both timely and relevant.

Recent findings
Next-generation sequencing has emerged as a cornerstone for diagnosing neonatal and infantile epilepsies, offering high diagnostic yields and enabling identification of etiology-specific phenotypes. Precision therapies, including sodium channel blockers, ganaxolone, and mammalian target of rapamycin (mTOR) inhibitors, target specific molecular mechanisms. Early initiation of treatment in conditions with a high risk of progressing to epilepsy, like vigabatrin in tuberous sclerosis complex, lower the incidence of infantile spasms and improve developmental outcomes. Drug repurposing has also provided effective options, such as fenfluramine in Dravet syndrome, with promising outcomes. Gene-based therapies, including antisense oligonucleotides and gene replacement, represent the new frontier for addressing the root causes of these disorders.

Summary
The integration of genetic and molecular advancements is transforming the management of neonatal and infantile epilepsies, fostering precision-driven care. Continued research and innovation are essential to refine these strategies, optimize patient outcomes, and establish new standards of care.
Analysis of the Application of Laparoscopic Peritoneal Lavage and Drainage in the Early Treatment of Severe Acute Pancreatitis
Authors: Yuan Hankun , Liang Wenxiang , You Shenglin , Zhou Jiajie , Chen Sizong , Tan Xijuan , Luo Qiyi , Ma Yufei , Lu Libai , Luo Zongjiang , Wang Jianchu 
Published: February 2025

Objective:
To investigate the clinical efficacy of laparoscopic peritoneal lavage and drainage (LPLD) in the early stage of severe acute pancreatitis (SAP) and its potential role in reversing organ failure.

Method:
This study involved 79 patients diagnosed with severe acute pancreatitis with ascites, who were admitted to the Affiliated Hospital of Youjiang Medical University of Nationalities between January 2020 and May 2024. Based on the intervention strategy, the patients were categorized into two groups: the abdominal paracentesis drainage (APD) group (n=42) and the LPLD group (n=37). We conducted a retrospective analysis comparing various parameters including demographic information, trends in inflammatory marker fluctuations, incidence of organ failure, step-up treatment, duration of ICU stay, drainage tube indwelling time, complications, total hospitalization days, total hospitalization cost , and mortality rates.

Results:
In addition to the observation that the preoperative volume of ascites was significantly greater in the APD group compared to the LPLD group (P = 0.005), the baseline characteristics of both groups were comparable. Postoperatively, The white blood cell count and C-reactive protein levels in the LPLD group exhibited a significantly faster decline compared to those in the APD group. (P < 0.05 and P < 0.001). There were no statistically significant differences in the rates of hemodialysis, pancreatic pseudocyst, abdominal compartment syndrome (ACS)，and mortality between the two patient groups. (P > 0.05). The LPLD group exhibited significantly reduced durations for mechanical ventilation, step-up treatment, duration of ICU stay, drainage tube indwelling time, duration of systemic inflammatory response syndrome (SIRS), incidence of intra-abdominal infection, new onset organ dysfunctions, total hospitalization days, and total hospitalization cost when compared to the APD group (P < 0.05).

Conclusions:
In patients with SAP complicated by ascites, early-stage LPLD can effectively alleviate systemic inflammatory response, expedite organ failure reversal, delay disease progression, avoid step-up treatment, reduce postoperative complications and shorten hospitalization duration. This minimally invasive therapeutic approach represents a promising strategy for early intervention in SAP.
Using Natural Language Processing (NLP) Methods to Predict Topics Included in 2019 Ohio Syphilis Disease Intervention Specialist (DIS) Records
Authors: Chakraborty Payal , Ning Xia , McNeill Mary , Kline David M. , Shoben Abigail B. , Miller William C. , Turner Abigail Norris 
Published: February 2025

Abstract

Background
Free-text notes in disease intervention specialist (DIS) records may contain relevant information for STI control. In their current form, the notes are not analyzable without manual reading, which is labor-intensive and prone to error.

Methods
We used natural language processing (NLP) methods to analyze 2019 Ohio DIS syphilis records with non-missing notes (n = 1,987). We identified 21 topics relevant for transmission and case investigations. We manually coded these records to create “gold standard” labels for each topic (0 = topic not present, 1 = topic present), then trained machine learning models to identify the topics in the text. For models to analyze text data, the text must be converted to numbers. We explored two approaches to numerically represent words: (1) term frequency, inverse document frequency (TF-IDF), which measures importance of words based on how many times they appear in a record and in the dataset as a whole, and (2) GloVe embeddings, which are numerical vectors that were developed by researchers for each word in the English language to encode its semantic meaning. We explored three types of statistical models (naïve Bayes, support vector machine [SVM], and logistic regression) using TF-IDF, and one type of neural network model (long short-term memory [LSTM] model) using GloVe. All models were used for binary prediction (i.e., topic not present, topic present).

Results
For most topics, the LSTM model performed the best overall in identifying topics, and the SVM model performed the best among the statistical models. For example, the LSTM model predicted the topic “substance use” with high accuracy (97%), sensitivity (92%), and specificity (98%). No model performed well for uncommon topics (e.g., “alcohol use” or “delays in care”).

Conclusions
Machine learning models performed well in identifying some topics in 2019 Ohio syphilis records. This analysis is a first step in applying NLP methods to making DIS notes more accessible for analysis.
Pharmacy-Based Data to Care: Evaluation of a Public Health Initiative to Support HIV Medication Re-Initiation
Authors: Dombrowski Julia C. , Hoopes Teah , Loeffelbein Robert , Muccioli Alexa , Rowlinson Emily , Lechtenberg Richard , McKay Christine , Blum Michal , Hardaswick Suzanne , Golden Matthew R. 
Published: February 2025

ABSTRACT
In a pharmacy-based Data to Care project in Washington during August 2019-December 2021, two pharmacies identified 762 cases of persons who were 35-65 days late refilling antiretroviral medications; 119 (16%) case investigations led to contact with a person who had discontinued treatment, 43 (36%) of whom restarted medications after outreach.
Arterial Occlusion in Takayasu Arteritis Detected as a Blood Pool Defect on 18F-FDG Semiconductor PET/CT
Authors: Koyama Masahiro , Matsusaka Yohji , Watanabe Kaho , Seto Akira , Kuji Ichiei 
Published: February 2025

Abstract
A 75-year-old woman with Takayasu arteritis was referred to 18F-FDG PET/CT due to elevated C-reactive protein in her laboratory data. FDG PET/CT with semiconductor detectors revealed no uptake in the arterial walls, suggesting active inflammation. However, the blood pool uptake in the proximal portion of the left subclavian artery was defective, suggesting arterial occlusion. Magnetic resonance angiography revealed complete occlusion of the left subclavian artery. Ultrasonography showed the reverse flow of the left vertebral artery. Semiconductor PET can visualize the blood pool defects of the intra-arterial uptake in the arterial branches from the aorta.
Ruptured Primitive Trigeminal Artery Aneurysm Leading to Internal Carotid Artery Cavernous Sinus Fistula Intervention
Authors: Chu Fudi , Li Mingjian , Li Wei , Wang Jinpeng 
Published: February 2025

Background:
Internal carotid artery cavernous sinus fistula (CCF) occurs when the cavernous segment of the internal carotid artery or its branches within the cavernous sinus rupture, creating an abnormal communication between arterial and venous blood. This leads to increased pressure within the cavernous sinus and a range of clinical manifestations. The prevalence of CCF is ~0.17% to 0.27%. Its etiology can be classified into 2 main types: traumatic, accounting for about 75% of cases, and spontaneous, accounting for the remaining 25%. The primitive trigeminal artery (PTA) is a rare remnant of the embryonic circulatory system that forms a connection between the internal carotid artery and the vertebrobasilar system. Its prevalence is estimated at 0.1% to 0.6%. A rupture of a PTA aneurysm leading to a cavernous sinus fistula of the internal carotid artery is even more uncommon. Current clinical approaches to managing this condition are still evolving and require further study.

Case Report:
A 53-year-old female patient presented with a one-month history of diplopia. Digital subtraction angiography (DSA) revealed a ruptured aneurysm of the primitive trigeminal artery, resulting in a cavernous sinus fistula of the internal carotid artery. After discussions with her family, she underwent successful interventional embolization to treat the fistula. At the 6-month follow-up, the patient’s diplopia had resolved completely, and no recurrence of the cavernous sinus fistula was observed on DSA.

Conclusion:
Rupture of a primitive trigeminal artery aneurysm resulting in a cavernous sinus fistula of the internal carotid artery is an exceptionally rare condition. Transarterial embolization has proven to be a feasible treatment approach; however, due to the limited number of reported cases, treatment strategies require further investigation and refinement.