bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring and improving quality in esophageal care and swallowing disorders
Authors: Reddy Alexander T , Lee Joshua P , Leiman David A 
Published: March 2024

Summary
Evaluating clinical care through quality-related metrics is increasingly common. There are now numerous quality statements and indicators related to the medical management of benign and pre-malignant esophageal diseases. Expert consensus leveraging evidence-based recommendations from published society guidelines has been the most frequently used basis for developing esophageal quality statements. While surgical care of patients with esophageal malignancies, including squamous cell carcinoma, has also been developed, those related to benign esophageal disease now include domains of diagnosis, treatment, and monitoring for gastroesophageal reflux disease, eosinophilic esophagitis (EoE), achalasia, and Barrett’s esophagus (BE). Several recent studies evaluating adherence to quality metrics affirm substantial variation in practice patterns with opportunities for improvement in care across esophageal diseases. In particular, patient education regarding treatment options in achalasia, frequency of esophageal biopsies among patients with dysphagia to evaluate for EoE, and endoscopic evaluation within a BE segment are areas identified to have need for improvement. As the management of esophageal diseases becomes more complex and interdisciplinary, adherence to quality metrics may be a source of standardization and improvement in delivery and ultimately patient outcomes. Indeed, the development of national quality databases has resulted in a significant growth in the use of these metrics for quality improvement activities and may form the basis for future inclusion in quality reporting and payment programs.
The ESTS-AIR database—initial results of a multi-institutional database on airway surgery
Authors: Schweiger Thomas , Evermann Matthias , Rendina Erino , Maurizi Giulio , Venuta Federico , Aigner Clemens , Slama Alexis , Collaud Stephane , Verhagen Ad , Timman Simone , Bibas Benoit , Cardoso Paulo , Passani Stefano , Salati Michele , Opitz Isabelle , Szanto Zalan , Hoetzenecker Konrad 
Published: March 2024

Abstract

OBJECTIVES
Compared to lung resections, airway procedures are relatively rare in thoracic surgery. Despite this, a growing number of dedicated airway centres have formed throughout Europe. These centres are characterized by a close interdisciplinary collaboration and they often act as supra-regional referring centres. To date, most evidence of airway surgery comes from retrospective, single-centre analysis as there is a lack of large-scale, multi-institutional databases.

METHODS
In 2018, an initiative was formed, which aimed to create an airway database within the framework of the ESTS database (ESTS-AIR). Five dedicated airway centres were asked to test the database in a pilot phase. A 1st descriptive analysis of ESTS-AIR was performed.

RESULTS
A total of 415 cases were included in the analysis. For adults, the most common indication for airway surgery was post-tracheostomy stenosis and idiopathic subglottic stenosis; in children, most resections/reconstructions had to be performed for post-intubation stenosis. Malignant indications required significantly longer resections [36.0 (21.4–50.6) mm] when compared to benign indications [26.6 (9.4–43.8) mm]. Length of hospital stay was 11.0 (4.1–17.3) days (adults) and 13.4 (7.6–19.6) days (children). Overall, the rates of complications were low with wound infections being reported as the most common morbidity.

CONCLUSIONS
This evaluation of the 1st cases in the ESTS-AIR database allowed a large-scale analysis of the practice of airway surgery in dedicated European airway centres. It provides proof for the functionality of ESTS-AIR and sets the basis for rolling out the AIR subsection to all centres participating in the ESTS database.
‘A troupe of mercenary writers’: the publicists in Chancellor Maupeou’s service, 1771–1774
Authors: Cossarutto Vincent 
Published: March 2024

Abstract
Louis XV’s government led an ambitious communications campaign in 1771 to justify his power grab against the parlements. Chancellor Maupeou enlisted a propaganda office that notably included his personal secretary, Charles-François Lebrun, and François Marin, the secrétaire général of the Librairie. The minister also relied on the commitment of a group of writers. François-Marie Arouet Voltaire was the most famous of these writers, but other, less well-known authors also played a crucial part. This was notably the case with the Abbé Raymond Mary, a humble canon linked to the comtesse du Barry’s circle, who was arguably one of the most important actors in Versailles’ persuasion strategy. This article sketches a portrait of the publicists who put pen to paper in the monarchy’s service during the Maupeou revolution.
Legacies of Colonial Violence in Contemporary Transitional Justice: Memories of Mau Mau, the ‘Kapenguria Six’ and the ‘Ocampo Six’ in Kenya
Authors: Sehmi Anushka 
Published: March 2024

ABSTRACT∞
This article assesses the enduring impact of colonial violence in responses to modern conflict by transitional justice mechanisms. It presents an example of how societies continue to be structured by racial and colonial injustice and how this influences contemporary transitional justice. This is done through an analysis of the popular memory of the Mau Mau insurgency from 1952 to 1960 in Kenya, the trial of the six Kenyan nationalists known as the ‘Kapenguria Six’ by the British colonial administration and the trials of six Kenyans alleged to be most responsible for orchestrating the 2007–2008 post-election violence in Kenya, known as the ‘Ocampo Six’ before the International Criminal Court (ICC). In the Kenyan context, the influence of memories of colonial violence enabled the promotion of political agendas and arguably coloured public debate surrounding the two Kenya cases before the ICC. Transitional justice mechanisms such as the ICC do not operate in an ahistorical vacuum and international criminal trials as a form of transitional justice may be contested where there is no genuine accountability, redress or reparations for victims of colonial crimes. However, the juxtaposition of colonial crimes and the ICC prosecutions in Kenya also raises important questions relating to accountability for historical crimes in former colonies, the temporal limitations of transitional justice mechanisms and their unequal application.
Pharmacokinetics and pharmacodynamics of high-dose isoniazid for the treatment of rifampicin- or multidrug-resistant tuberculosis in Indonesia
Authors: Yunivita Vycke , Gafar Fajri , Santoso Prayudi , Chaidir Lidya , Soeroto Arto Y , Meirina Triana N , Te Brake Lindsey , Menzies Dick , Aarnoutse Rob E , Ruslami Rovina 
Published: March 2024

Abstract

Background
Pharmacokinetic data on high-dose isoniazid for the treatment of rifampicin-/multidrug-resistant tuberculosis (RR/MDR-TB) are limited. We aimed to describe the pharmacokinetics of high-dose isoniazid, estimate exposure target attainment, identify predictors of exposures, and explore exposure–response relationships in RR/MDR-TB patients.

Methods
We performed an observational pharmacokinetic study, with exploratory pharmacokinetic/pharmacodynamic analyses, in Indonesian adults aged 18–65 years treated for pulmonary RR/MDR-TB with standardized regimens containing high-dose isoniazid (10–15 mg/kg/day) for 9–11 months. Intensive pharmacokinetic sampling was performed after ≥2 weeks of treatment. Total plasma drug exposure (AUC0–24) and peak concentration (Cmax) were assessed using non-compartmental analyses. AUC0–24/MIC ratio of 85 and Cmax/MIC ratio of 17.5 were used as exposure targets. Multivariable linear and logistic regression analyses were used to identify predictors of drug exposures and responses, respectively.

Results
We consecutively enrolled 40 patients (median age 37.5 years). The geometric mean isoniazid AUC0–24 and Cmax were 35.4 h·mg/L and 8.5 mg/L, respectively. Lower AUC0–24 and Cmax values were associated (P &lt; 0.05) with non-slow acetylator phenotype, and lower Cmax values were associated with male sex. Of the 26 patients with MIC data, less than 25% achieved the proposed targets for isoniazid AUC0–24/MIC (n = 6/26) and Cmax/MIC (n = 5/26). Lower isoniazid AUC0–24 values were associated with delayed sputum culture conversion (&gt;2 months of treatment) [adjusted OR 0.18 (95% CI 0.04–0.89)].

Conclusions
Isoniazid exposures below targets were observed in most patients, and certain risk groups for low isoniazid exposures may require dose adjustment. The effect of low isoniazid exposures on delayed culture conversion deserves attention.
Analysis of over 250 novel synthetic opioids and xylazine by LC–MS-MS in blood and urine
Authors: Diekhans Katie , Yu Jihau , Farley Megan , Rodda Luke N 
Published: March 2024

Abstract
Novel Synthetic Opioids (NSO) are frequently found in postmortem (PM) and human performance (HP) forensic toxicology casework, resulting in impairment and fatal overdoses. Developing a broad NSO method benefits public health, as it can be used to identify trends in potent opioid use to develop risk management programs. This project aimed to design a comprehensive, rapid and routine method for the selective analysis of over 250 novel synthetic opioids in blood and urine. This method rapidly extracted 150 µL of blood or urine via protein precipitation followed by size-exclusion filtration, evaporation and reconstitution. Separation and data acquisition were achieved on a 12 min LC–MS-MS method using an F5 column. Data processing was expedited with a custom built-in query created in-house that automated processing and enhanced quality assurance. Validation according to ASB/ANSI Standard 036 was performed and applicability of the method was assessed using proficiency test and authentic casework samples. Assessed in blood and urine qualitatively were 261 unique analytes including fentanyl analogs (fentalogs), nitazenes and other miscellaneous synthetic opioids. As 59 isomeric target analytes were placed into groups due to co-elution, there were 202 distinct acquired targets or target - groups. To demonstrate applicability, 27 proficiency test blood samples received over an approximate 4-year period were analyzed with 126 expected results assessed comprising 25 unique target analytes. Additionally, 617 fatal accidental overdoses within San Francisco in 2022 were retroactively analyzed by this method with almost 10% of cases containing a new NSO substance(s). Such trends and NSO substances were previously unknown in this community.
Identification of clobromazolam in Australian emergency department intoxications using data-independent high-resolution mass spectrometry and the HighResNPS.com database
Authors: Castle Jared W , Syrjanen Rebekka , Di Rago Matthew , Schumann Jennifer L , Greene Shaun L , Glowacki Linda L , Gerostamoulos Dimitri 
Published: March 2024

Abstract
The proliferation of novel psychoactive substances (NPSs) continues to challenge toxicology laboratories. In particular, the United Nations Office on Drugs and Crime considers designer benzodiazepines to be a current primary threat among all NPSs. Herein, we report detection of a new emerging designer benzodiazepine, clobromazolam, using high-resolution mass spectrometry and untargeted data acquisition in combination with a “suspect screening” method built from the crowd-sourced HighResNPS.com database. Our laboratory first detected clobromazolam in emergency department presenting intoxications included within the Emerging Drugs Network of Australia—Victoria project in the state of Victoria, Australia, from April 2022 to March 2023. Clobromazolam was the most frequent designer benzodiazepine detected in this cohort (100/993 cases, 10%). No patients reported intentional administration of clobromazolam, although over half reported exposure to alprazolam, which was detected in only 7% of cases. Polydrug use was prevalent (98%), with phenazepam (45%), methylamphetamine (71%) and other benzodiazepines (60%) most frequently co-detected. This is the first case series published in the literature concerning clobromazolam in clinical patients. The identification of clobromazolam in patients presenting to emergency departments in Victoria demonstrates how high-resolution mass spectrometry coupled with the HighResNPS.com database can be a valuable tool to assist toxicology laboratories in keeping abreast of emerging psychoactive drug use.
Evaluation of a novel triple-action adulticide containing a pyrethroid, macrocyclic lactone, and fatty acid against pyrethroid-resistant Aedes aegypti and Culex quinquefasciatus (Diptera: Culicidae)
Authors: Lucas Keira J , Heinig Rebecca , Lake Leanne , Williams Katie , Parker-Crockett Casey , Bales Rachel , McDuffie Decyo 
Published: March 2024

Abstract
Insecticide resistance in mosquito populations has long been recognized as a significant global public health challenge, motivating the development of new control chemistries. ReMoa Tri is a novel triple-action space spray that employs a different mode of action than traditional adult mosquito control formulations. It combines 3 components: fenpropathrin, a mixed-type I/II pyrethroid; abamectin, a macrocyclic lactone; and C8910, a patented fatty acid chain. As an ultra-low volume adulticide, ReMoa Tri has the potential to target mosquito species that are resistant to pyrethroid and organophosphate-based control materials. To determine whether ReMoa Tri effectively targets resistant mosquito species in Florida’s Collier County, United States, we conducted ground-based field cage trials using field-caught pyrethroid-resistant Culex quinquefasciatus (Say) and Aedes aegypti (L.), of which the latter also displayed developing resistance to organophosphates. Trials were also conducted against the same mosquito populations with Merus 3.0, a pyrethrin-based adulticide used by the Collier Mosquito Control District. ReMoa Tri was effective against Collier’s pyrethroid-resistant Cx. quinquefasciatus, resulting in more than 95% mortality in semifield cage trials by 24 h postapplication. Similarly, ReMoa Tri applications against Collier’s pyrethroid-resistant Ae. aegypti resulted in 72%–89% mortality at 24 h postapplication and 74%–97% mortality at 48 h postapplication. This study represents the first field data on this novel space spray, and its findings shed light on the performance of ReMoa Tri against local mosquito populations that have developed resistance to currently available adulticides.
All That Is Solid Bursts into Flame: Capitalism and Fire in the Nineteenth-Century United States
Authors: Immerwahr Daniel 
Published: March 2024

Abstract
Industrial capitalism arrived in Europe as great urban fires were already retreating. The United States, however, was generously timbered and far more reliant on wooden construction. As a result, its infernos continued, and even increased, well into its age of capital. They especially struck places of intense commodification: hastily built settler towns, slave cities, financial centres and sites of mineral extraction. Noting the connection between fire and capitalism, a class of upwardly mobile strivers came to appreciate fires for their ability to disrupt social hierarchies, reset property relations and nurture economic dynamism. Oddly, many who had suffered fires even interpreted them as ‘blessings in disguise’. This pyrophilia was not universal, however, and the richest men of the Gilded Age strenuously opposed it, seeking instead to fireproof the environment. The clash between pyrophobes and pyrophiles was between economic incumbents and economic insurgents, and it touched on many areas of late nineteenth-century culture. Familiar Gilded Age artefacts such as Chicago’s White City and L. Frank Baum’s The Wonderful Wizard of Oz can be productively understood in terms of this widespread fight over the value of fire, and thus the shape of capitalism.
Rheumatoid arthritis and risk of osteoarticular infection and death following Staphylococcus aureus bacteraemia: a nationwide cohort study
Authors: Dieperink Sabine S , Nørgaard Mette , Mehnert Frank , Oestergaard Louise B , Benfield Thomas , Torp-Pedersen Christian , Petersen Andreas , Glintborg Bente , Hetland Merete L 
Published: March 2024

Abstract

Objectives
Osteoarticular infection (OAI) is a feared complication of Staphylococcus aureus bacteraemia (SAB) and is associated with poor outcomes. We aimed to explore the risk of OAI and death following SAB in patients with and without rheumatoid arthritis (RA) and to identify risk factors for OAI in patients with RA.

Methods
Danish nationwide cohort study of all patients with microbiologically verified first-time SAB between 2006–18. We identified RA, SAB, comorbidities, and RA-related characteristics (e.g. orthopaedic implants and antirheumatic treatment) in national registries including the rheumatology registry DANBIO. We estimated the cumulative incidence of OAI and death and adjusted hazard ratios (HRs, multivariate Cox regression).

Results
We identified 18 274 patients with SAB (n = 367 with RA). The 90-day cumulative incidence of OAI was 23.1% (95% CI 18.8; 27.6) for patients with RA and 12.5% (12.1; 13.0) for patients without RA (non-RA) [HR 1.93 (1.54; 2.41)]. For RA patients with orthopaedic implants cumulative incidence was 29.4% (22.9; 36.2) [HR 1.75 (1.08; 2.85)], and for current users of tumor necrosis factor inhibitors (TNFi) it was 41.9% (27.0; 56.1) [HR 2.27 (1.29; 3.98) compared with non-users]. All-cause 90-day mortality following SAB was similar in RA [35.4% (30.6; 40.3)] and non-RA [33.9% (33.2; 34.5), HR 1.04 (0.87; 1.24)].

Conclusion
Following SAB, almost one in four patients with RA contracted OAI corresponding to a doubled risk compared with non-RA. In RA, orthopaedic implants and current TNFi use were associated with approximately doubled OAI risk. One in three died within 90 days in both RA and non-RA. These findings encourage vigilance in RA patients with SAB to avoid treatment delay of OAI.
The Rejuvenation and Functional Restoration of Aged Adipose Stem Cells by DUXAP10 Knockdown via the Regulation of the miR-214-3p/RASSF5 Axis
Authors: Ren Sen , Li Chengcheng , Xiong Hewei , Wu Qian , Wu Xiaohui , Xiong Zhongwei , Dong Lixing , Shu Bing , Wei Wei , Ma Chao , Li Xiang , Chen Jincao 
Published: March 2024

Abstract
Adipose stem cell (ASC)-based therapies provide an encouraging option for tissue repair and regeneration. However, the function of these cells declines with aging, which limits their clinical transformation. Recent studies have outlined the involvement of long non-coding RNAs in stem cell aging. Here, we reanalyzed our published RNA sequencing (RNA-seq) data profiling differences between ASCs from young and old donors and identified a lncRNA named double homeobox A pseudogene 10 (DUXAP10) as significantly accumulated in aged ASCs. Knocking down DUXAP10 promoted stem cell proliferation and migration and halted cell senescence and the secretion of proinflammatory cytokines. In addition, DUXAP10 was located in the cytoplasm and functioned as a decoy for miR-214-3p. miR-214-3p was downregulated in aged ASCs, and its overexpression rejuvenated aged ASCs and reversed the harm caused by DUXAP10. Furthermore, Ras Association Domain Family Member 5 (RASSF5) was the target of miR-214-3p and was upregulated in aged ASCs. Overexpressing DUXAP10 and inhibiting miR-214-3p both enhanced RASSF5 content in ASCs, while DUXAP10 knockdown promoted the therapeutic ability of aged ASCs for skin wound healing. Overall, this study offers new insights into the mechanism of age-related ASC dysfunction and names DUXAP10 and miR-214-3p as potential targets for energizing aged stem cells.
Multidisciplinary Approach for the Management of Metastatic Poorly Differentiated Neuroendocrine Carcinoma of the Pancreas
Authors: Nakasone Elizabeth S. , Bustillos Hannah C. , Gui Xianyong , Konnick Eric Q. , Sham Jonathan G. , Cohen Stacey A. 
Published: March 2024

Abstract
Poorly differentiated pancreatic neuroendocrine carcinomas (pNECs) are rare, highly aggressive neoplasms. Frequently metastatic at diagnosis, prognosis is poor with median overall survival estimated to be less than 1 year. Although multidisciplinary management, including systemic medications and locoregional therapies aimed at reducing and preventing symptoms caused by mass effect, is the mainstay of treatment for patients with metastatic well-differentiated pancreatic neuroendocrine tumors, rapid progression, organ dysfunction, and poor performance status often preclude initiation of even single-modality palliative chemotherapy for patients with metastatic pNEC, limiting the use of and recommendation for multidisciplinary management.
We describe the case of a 51-year-old male patient diagnosed with pNEC metastatic to liver and lymph nodes presenting with impending cholestatic liver failure for whom we were able to successfully initiate and dose-escalate cytotoxic chemotherapy with excellent radiographic response. After multidisciplinary review of his case, the patient underwent pancreaticoduodenectomy and hepatic wedge biopsies, with pathology demonstrating a pathologic complete response to chemotherapy in both the pancreas and liver. Surveillance scans at 2 years from initial diagnosis and 1 year from surgery remain without evidence of locoregional or distant recurrence, highlighting the importance and utility of multidisciplinary management in select cases.
Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Editing
Authors: Wang Minjing , Krueger Joshua B. , Gilkey Alexandria K. , Stelljes Erin M. , Kluesner Mitchell G. , Pomeroy Emily J. , Skeate Joseph G. , Slipek Nicholas J. , Lahr Walker S. , Vázquez Patricia N. Claudio , Zhao Yueting , Eaton Ella J. , Laoharawee Kanut , Webber Beau R. , Moriarity Branden S. 
Published: March 2024

AbstractNatural killer (NK) cells’ unique ability to kill transformed cells expressing stress ligands or lacking major histocompatibility complexes (MHC) has prompted their development for immunotherapy. However, NK cells have demonstrated only moderate responses against cancer in clinical trials and likely require advanced genome engineering to reach their full potential as a cancer therapeutic. Multiplex genome editing with CRISPR/Cas9 base editors (BE) has been used to enhance T cell function and has already entered clinical trials but has not been reported in human NK cells. Here, we report the first application of BE in primary NK cells to achieve both loss-of-function and gain-of-function mutations. We observed highly efficient single and multiplex base editing, resulting in significantly enhanced NK cell function. Next, we combined multiplex BE with non-viralTcBustertransposon-based integration to generate IL-15 armored CD19 CAR-NK cells with significantly improved functionality in a highly suppressive model of Burkitt’s lymphoma bothin vitroandin vivo. The use of concomitant non-viral transposon engineering with multiplex base editing thus represents a highly versatile and efficient platform to generate CAR-NK products for cell-based immunotherapy and affords the flexibility to tailor multiple gene edits to maximize the effectiveness of the therapy for the cancer type being treated.