bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fostering positive attitudes toward food in individuals with restrained eating: the impact of flexible food-related inhibition
Authors: Berebbi Shir , Naftalovich Hadar , Weinbach Noam , Kalanthroff Eyal 
Published: March 2024

AbstractIndividuals exhibiting restrained eating behaviors demonstrate increased inhibitory control when exposed to food-related stimuli, indicating the presence of an automatic food-inhibition association. Existing literature proposes that this association contributes to the devaluation of food within this population. Efforts to disrupt this association by promoting the complete elimination of the inhibition of food responses have resulted in increased food consumption but have also led to heightened food-related anxiety in individuals with restrained eating behaviors. In the current investigation, we investigated whether a novel flexible food response/inhibition computerized task could yield favorable changes in attitudes toward food in individuals with restrained eating. We randomly assigned 78 females who engage in restrained eating to one of three training groups. In the flexible response/inhibition group, participants were instructed to equally inhibit or respond to food stimuli. In the response group, participants consistently responded to food stimuli, while in the inhibition group, participants consistently inhibited their response to food cues. Implicit attitudes toward food were assessed both before and after the manipulation. To examine the stability of the effect of the training, participants also engaged in a seemingly unrelated bogus taste test. Our results revealed that only the flexible response/inhibition group demonstrated a significant improvement in positive attitudes toward high-calorie foods after eating, while there were no observable changes in negative attitudes among the other two groups. These findings suggest that promoting a balance between the responding and inhibiting responses to food stimuli can increase positive attitudes toward food amongst individuals with restrained eating.
Tipping the balance in autoimmunity: are regulatory t cells the cause, the cure, or both?
Authors: Hardtke-Wolenski Matthias , Landwehr-Kenzel Sybille 
Published: March 2024

AbstractRegulatory T cells (Tregs) are a specialized subgroup of T-cell lymphocytes that is crucial for maintaining immune homeostasis and preventing excessive immune responses. Depending on their differentiation route, Tregs can be subdivided into thymically derived Tregs (tTregs) and peripherally induced Tregs (pTregs), which originate from conventional T cells after extrathymic differentiation at peripheral sites. Although the regulatory attributes of tTregs and pTregs partially overlap, their modes of action, protein expression profiles, and functional stability exhibit specific characteristics unique to each subset. Over the last few years, our knowledge of Treg differentiation, maturation, plasticity, and correlations between their phenotypes and functions has increased. Genetic and functional studies in patients with numeric and functional Treg deficiencies have contributed to our mechanistic understanding of immune dysregulation and autoimmune pathologies. This review provides an overview of our current knowledge of Treg biology, discusses monogenetic Treg pathologies and explores the role of Tregs in various other autoimmune disorders. Additionally, we discuss novel approaches that explore Tregs as targets or agents of innovative treatment options.
A case of indirect inguinal bladder hernia treated with laparoscopic transabdominal preperitoneal repair with high peritoneal incisional approach
Authors: Zotani Hitomi , Yamamoto Tetsu , Hyakudomi Ryoji , Takai Kiyoe , Taniura Takahito , Ishitobi Kazunari , Hirahara Noriyuki , Tajima Yoshitsugu , Hidaka Masaaki 
Published: March 2024

Abstract
Background
Inguinal herniation of the urinary bladder is uncommon and those descending into the scrotum are even rarer. Although open anterior repair has been used for inguinal bladder hernia, the efficacy of laparoscopic herniorrhaphy has been reported in recent years.

Case presentation
A 63-year-old man presented with an irreducible right groin and scrotal bulge associated with voiding difficulty. Abdominal ultrasonography showed a dislocation of the urinary bladder descending into the right scrotum. Abdominal CT imaging revealed that a part of the bladder and small intestine was herniating into the scrotum through the internal inguinal ring and running laterally to the inferior epigastric artery. Under the diagnosis of indirect inguinal bladder hernia, the patient underwent trans-abdominal preperitoneal hernia repair (TAPP). The bladder herniated into the scrotum through the internal inguinal ring was replaced to the original position. Then the myopectineal orifice was exposed and covered with polypropylene mesh, where a horizontal peritoneal incision 4 cm above the hernia orifice, i.e., the high peritoneal incision approach (HPIA), allowed an easy peeling of the peritoneum and hernia sac. The patient’s postoperative course was uneventful and the voiding difficulty resolved. The patient continued to do well without recurrence at 20 months after surgery.

Conclusion
Preoperative evaluation with abdominal ultrasonography and CT scan allowed a precise diagnosis of a groin hernia with voiding difficulty. TAPP with HPIA was useful in the treatment of inguinal bladder hernia because this technique facilitated a quick confirmation of the hernia contents, secure dissection of the whole protruded bladder, and adequate replacement of the bladder to the original position without any injury.
Transgender and non-binary patient simulations can foster cultural sensitivity and knowledge among internal medicine residents: a pilot study
Authors: Borowicz Charlie , Daniel Laura , Futcher Regina D. , Wilfong Donamarie N. 
Published: March 2024

AbstractTransgender and nonbinary patients face unique healthcare challenges, such as harassment, discrimination, and/or prejudice, at higher rates than their cisgender counterparts. These experiences, or even the fear of these experiences, may push patients to delay or forego medical treatment, thus compounding any existing conditions. Such extraneous issues can be combatted through cultural sensitivity. The authors designed blended education consisting of an online module followed by a live simulation to educate and promote sensitivity. Internal medicine (IM) residents (n = 94) completed the module, which introduced them to transgender community terminology and medical disparities, and ways to incorporate affirming behaviors into their practice. Afterward, they engaged in a simulation with true transgender-simulated patients (SPs) — either trans-masculine, trans-feminine, or non-binary. Residents were expected to conduct a patient interview mirroring an intake appointment. Residents then engaged in a debriefing session with the lead investigator and the SP to reflect on the experience, receive feedback and constructive criticism, and ask questions. After the education, the residents’ knowledge significantly increased, t(66) = 3.69, p ≤ 0.00, d = 0.45, and their attitude toward members of the transgender community also increased significantly, t(62) = 7.57, p ≤ 0.00, d = 0.95. Furthermore, nearly all residents (99%) reported the training allowed them to practice relevant skills and was a worthy investment of their time. Nearly half (45%) of the residents who listed changes they will make to their practice pledged to ask patients for their preferred name and pronouns. Most comments were positive (75%), praising the education’s effectiveness, expressing gratitude, and reporting increased confidence. Results provided evidence that the education was effective in increasing IM residents’ knowledge and attitudes. Further research is needed to investigate the longitudinal effects of this education and to extend the education to a broader audience. The investigators plan to adapt and expand the research to other specialties such as gynecology and emergency medicine.
Anesthetic Sevoflurane Induces Enlargement of Dendritic Spine Heads in Mouse Neurons via Tau-Dependent Mechanisms
Authors: Yan Jia , Ton Hoai , Yan Jing , Dong Yuanlin , Xie Zhongcong , Jiang Hong 
Published: March 2024

BACKGROUND:
Sevoflurane induces neuronal dysfunction and cognitive impairment. However, the underlying mechanism remains largely to be determined. Tau, cyclophilin D, and dendritic spine contribute to cognitive function. But whether changes in dendritic spines are involved in the effects of sevoflurane and the potential association with tau and cyclophilin D is not clear.

METHODS:
We harvested hippocampal neurons from wild-type mice, tau knockout mice, and cyclophilin D knockout mice. We treated these neurons with sevoflurane at day in vitro 7 and measured the diameter of dendritic spine head and the number of dendritic spines. Moreover, we determined the effects of sevoflurane on the expression of excitatory amino acid transporter 3 (EAAT3), extracellular glutamate levels, and miniature excitatory postsynaptic currents (mEPSCs). Finally, we used lithium, cyclosporine A, and overexpression of EAAT3 in the interaction studies.

RESULTS:
Sevoflurane-induced tau phosphgorylation increased the diameter of dendritic spine head and decreased the number of dendritic spines in neurons harvested from wild-type and cyclophilin D knockout mice, but not tau knockout mice. Sevoflurane decreased the expression of EAAT3, increased extracellular glutamate levels, and decreased the frequency of mEPSCs in the neurons. Overexpression of EAAT3 mitigated the effects of sevoflurane on dendritic spines. Lithium, but not cyclosporine A, attenuated the effects of sevoflurane on dendritic spines. Lithium also inhibited the effects of sevoflurane on EAAT3 expression and mEPSCs.

CONCLUSIONS:
These data suggest that sevoflurane induces a tau phosphorylation-dependent demtrimental effect on dendritic spine via decreasing EAAT3 expression and increasing extracellular glutamate levels, leading to neuronal dysfunction.
Brain-Hazardous Medications and Potential Subadequate Antidepressant Dosing in Older Surgical Patients Receiving Home Antidepressants: An Observational Study of a Large US Health System
Authors: Pennington Bethany R. Tellor , Holzer Katherine J. , Fritz Bradley A. , Haroutounian Simon , Xu Kevin Y. , Tedder Amanda , Kronzer Alex , Avidan Michael S. , Lenze Eric J. 
Published: March 2024

BACKGROUND:
Older surgical patients with depression often experience poor postoperative outcomes. Poor outcomes may stem from brain-hazardous medications and subadequate antidepressant dosing.

METHODS:
This was a retrospective, observational cohort study covering the period between January 1, 2021 and December 31, 2021. Patients ≥60 years of age who underwent inpatient surgery and had an overnight stay at an integrated academic health care system comprising 14 hospitals were eligible. We analyzed the prevalence of home central nervous system (CNS)-active potentially inappropriate medication (PIM) and potential subadequate antidepressant dosing in older surgical patients receiving home antidepressants. Univariable and multivariable regression models were used to identify factors associated with home CNS-active PIM prescribing and potential subadequate antidepressant dosing. Additionally, outcomes were compared among patients receiving and not receiving CNS-active PIMs and patients receiving and not receiving subadequate antidepressant dosing.

RESULTS:
A total of 8031 patients were included in this study (47% female, mean age = 70 years) of whom 2087 (26%) were prescribed antidepressants. Roughly one-half (49%, 95% confidence interval [CI], 46.5–50.1) of patients receiving home antidepressants were also receiving ≥1 CNS-active PIM and 29% (95% CI, 27.0–29.3) were receiving a potential subadequate dose. Factors associated with an increased likelihood of receiving a home CNS-active PIM included female sex (adjusted odds ratio [aOR], 1.46), anxiety (aOR, 2.43), asthma or chronic obstructive pulmonary disease (aOR, 1.39), and serotonin-norepinephrine reuptake inhibitor use (aOR, 1.54). Patients aged ≥75 years (aOR, 1.57), black race (aOR, 1.48) and those with congestive heart failure (aOR, 1.33) were more likely to be prescribed a potential subadequate antidepressant dose. Patients receiving potential subadequate antidepressant doses were discharged home less often (64% vs 73%), had a longer hospital length of stay (9 days vs 7 days), and a higher mortality rate (18% vs 10%) compared to patients receiving adequate home antidepressant doses (P-value for all <0.01). No differences in these outcomes were found among patients receiving home antidepressants with or without CNS-active PIMs.

CONCLUSIONS:
Older surgical patients receiving antidepressants are frequently prescribed brain-hazardous medications and potentially subadequate antidepressant doses. Those receiving subadequate antidepressant doses may be at risk for worse postoperative outcomes compared to patients receiving adequate doses. The role of preoperative medication optimization to improve outcomes for older surgical patients should be evaluated.
Return Migration and Fertility: French Overseas Emigrants, Returnees, and Nonmigrants at Origin and Destination
Authors: Haddad Marine , Pailhé Ariane 
Published: March 2024

Abstract
Although growing research has emphasized the critical importance of studying returns for understanding various aspects of migration processes, knowledge regarding return migrants’ fertility behaviors remains limited. This study addresses this knowledge gap by comparing rates of first births and completed fertility among three groups: nonmigrants (at origin), migrants, and return migrants. Using extensive data collected both in the home regions and at destination, we analyze female migration from Martinique, Guadeloupe, French Guiana, and Réunion Island to metropolitan France (European France). We find intermediate fertility behaviors for return migrants relative to nonmigrants and migrants: on average, completed fertility levels are lower among return migrants than nonmigrants but slightly higher among return migrants than migrants. Some of these differences can be attributed to selection into migration and return, although significant gaps persist among women with similar socioeconomic characteristics. Our findings highlight three key observations. First, when migrants return before beginning childbearing, their transition to motherhood closely resembles that of nonmigrants with similar characteristics. Second, the lower fertility rates among prospective return migrants indicate an anticipation of disruption effects. Finally, reduced fertility while residing in metropolitan France translates into lower completed fertility rates for return migrants.
Assessing the quality of antenatal care provision by midwives: a mixed-method study of three levels of healthcare in southwestern Nigeria
Authors: Ayamolowo Sunday Joseph , Adesoji Bukola Abimbola 
Published: March 2024

Background Antenatal care allows healthcare providers to assess the wellbeing of pregnant women and their fetuses, leading to positive maternal and fetal outcomes. This study assessed the available facilities for antenatal care provided by midwives, and factors that influenced the quality of care provided. Methods This study used a mixed-method descriptive design based on the Donabedian model to explore the quality of care at 27 health facilities across the three levels of healthcare in Osun State. Qualitative data were collected from 11 purposively selected midwives using an in-depth interview guide, and a hospital checklist was used to collect quantitative data. Data were gathered over 12 weeks, then transcribed and analysed using content and thematic analysis. Results Some facilities (9.1%) did not offer all components of antenatal care. When examining the process and structure of care, 98.6% of healthcare facilities were found to have inadequate human resources. Although the equipment at the facilities was functional, it was reportedly inadequate in 27 (84.3%) facilities. Midwives reported that a lack of education, poor working conditions, interprofessional barriers and burnout hindered the provision of quality antenatal care, while community support and regular continuing education were motivating factors. Conclusions The quality of antenatal care was rated adequate, but there was a lack of resources, standard guidelines and retraining opportunities for midwives. Adequate manpower and resources are needed to enhance the quality of antenatal care in health facilities in Osun State.
Mothers' knowledge and practice of infection prevention at Ridge Hospital, Ghana
Authors: Cletus Kantam Laari , Mavis Lui , Gilbert Nachinab Ti-Enkawol 
Published: March 2024

Background/Aims Neonatal infection is one of the most common health challenges for newborn care globally. It is also a common contributory reason for admission to neonatal intensive care units in low- and middle-income countries and one of the main causes of mortality and morbidity. This study aimed to assess mothers’ knowledge, practice and perception of factors affecting infection prevention. Methods A descriptive cross-sectional study was conducted among 193 neonatal mothers from August to September 2021. A structured questionnaire was used to collect data on knowledge and practice of infection prevention, as well as factors the participants felt impacted infection prevention. Data were analysed using descriptive statistics. Results The majority of mothers had good knowledge (93.3%) and practice (92.7%) of infection prevention. The participants reported multiple factors that they felt impacted neonatal infection prevention, including the mother's education (84.5%), home birth practices (89.1%), poor economic state (85.0%), poor antenatal attendance (93.3%), negative cultural and belief systems (94.8%) and a lack of knowledge of infection prevention (90.7%). Conclusions Overall, the majority of neonatal mothers had good knowledge and practice of infection prevention. The Ghana Health Service and Ministry of Health should encourage women to give birth at a health facility, to increase their knowledge of infection prevention, which will then be reflected in improved practice.
Effects of Shallow Surface Drainage Ditches With Controlled Subsurface Drainage Management on Crop Yields in North Carolina
Authors: Watkins Mitchell L. , Poole Chad , Youssef Mohamed A. , Moursi Hossam , Vann Rachel , Heiniger Ron 
Published: March 2024

HighlightsShallow surface ditches with controlled subsurface drainage (SD) increased corn and soybean yields in eight of nine growing seasons compared to conventional drainage.The SD system increased corn yields on average by 0.4 Mg/ha, or 4% (0.7 Mg/ha, or 6.6%, excluding 2016).The SD system increased soybean yields on average by 0.5 Mg/ha, or 14.3%.Abstract. Agricultural drainage in the coastal areas of North Carolina (NC) is commonly achieved through large trapezoidal-shaped ditches. The coastal region of NC has limited topographic relief (slopes &lt; 1%) with poorly drained soils that can cause substantial issues with surface water ponding during high-intensity or long-duration precipitation events without some form of surface drainage. Installation of large free flowing surface ditches (FD) with field crowning improves the drainage intensity but can create negative consequences such as over drainage and side slope scouring within the ditch. Large open ditches remove tillable land from production and serve as a primary transport pathway for pollutants. An alternative drainage design (SD) has been implemented that decreases the size of the surface ditches, limiting their drainage effect to only surface water and potentially improving equipment trafficability. The smaller ditches, installed with precision grade equipment, are placed on a grade sufficient to direct surface flow while keeping soil movement to a minimum. Lateral subsurface drainage tiles are installed to provide subsurface drainage and are connected to a main tile line operated with an outlet control structure for controlled drainage (CD). This study evaluates the crop yield and water table effects of the SD system compared to FD over nine crop seasons from 2014-2022. The SD treatment increased yield in eight of the nine crop seasons overall, four of five corn (Zea mays L.) crops, and all four soybean (Glycine max L.) crops. Overall, SD increased corn yields by 0.4 Mg/ha or 4% (0.7 Mg/ha or 6.6% with the exclusion of 2016) and soybean yields by 0.5 Mg/ha (14.3%). The effects of SD on crop yield and water table show that the system can be utilized to improve crop health and provide better management of cropland for producers. Keywords: Corn Yield, Drainage Water Management, Soybean Yield, Surface Drainage, Water Table.
Current status of contact lenses usage in Korea: A population-based cohort study 2021
Authors: Kim Minsun , Paik Ji-Sun , Kim Daran , Hwang Ho Sik , Han Kyungdo , Na Kyung-Sun 
Published: March 2024

Purpose
To investigate trends in contact lens usage in a nationally representative sample of the Korean population in 2021.

Methods
For this retrospective study, we analyzed data of 3,601 Korean participants aged 10–59 years, from the Korea National Health and Nutrition Examination Survey (KNHANES 2021 version), who underwent eye examination, of whom 1,136 individuals (274 men and 862 women) were contact lens users. The demographic trend among Korean contact lens wearers was examined using statistical analyses to investigate the changes in their contact lens-wearing experience, duration of lens use, type of lens used, location of purchase, presence of an Eye Care Practitioner(ECP)’s prescription, lens-related ophthalmic complications, and type of lenses worn at the time of complications, according to sex. Multivariable logistic regression analysis was conducted to examine the association of each variable with the rate of complications and use of soft lenses.

Results
The average age of the contact lens users was 33.42±0.33 years, with 70.36% (weighted percentage) of users being women who used contact lenses for significantly longer periods than men (p<0.001). Additionally, only wearing of cosmetic lenses was significantly correlated with the occurrence of complications (p = 0.006), and 6.76% of users purchased lenses without a prescription. Multivariate analysis among the contact lens users revealed a significant relationship between the complication rate and female sex (p = 0.002), pre-existing eye disease diagnosed by ECPs (p = 0.0288), and duration of contact lens use (p<0.0001).

Conclusion
We identified sex differences in contact lens usage trends in Korea. The main changes observed were an increase in middle-aged lens users and a decrease in female users compared to that in the early 2000s. In addition, contact lens complications were significantly associated with sex and pre-existing eye disease. Therefore, those wearing contact lenses for extended periods should exercise caution and consult eye care specialists in the presence of any symptoms.