bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding global research trends in the control and prevention of infectious diseases for children: Insights from text mining and topic modeling
Authors: Oh Won‐Oak , Lee Eunji , Heo Yoo‐jin , Jung Myung‐Jin , Han Jihee 
Published: February 2024

AbstractIntroductionThe emergence of novel infectious diseases has amplified the urgent need for effective prevention strategies, especially ones targeting vulnerable populations such as children. Factors such as the high incidence of both emerging and existing infectious diseases, delays in vaccinations, and routine exposure in communal settings heighten children's susceptibility to infections. Despite this pressing need, a comprehensive exploration of research trends in this domain remains lacking. This study aims to address this gap by employing text mining and modeling techniques to conduct a comprehensive analysis of the existing literature, thereby identifying emerging research trends in infectious disease prevention among children.MethodsA cross‐sectional text mining approach was adopted, focusing on journal articles published between January 1, 2003, and August 31, 2022. These articles, related to infectious disease prevention in children, were sourced from databases such as PubMed, CINAHL, MEDLINE (Ovid), Scopus, and Korean RISS. The data underwent preprocessing using the Natural Language Toolkit (NLTK) in Python, with a semantic network analysis and topic modeling conducted using R software.ResultsThe final dataset comprised 509 journal articles extracted from multiple databases. The study began with a word frequency analysis to pinpoint relevant themes, subsequently visualized through a word cloud. Dominant terms encompassed “vaccination,” “adolescent,” “infant,” “parent,” “family,” “school,” “country,” “household,” “community,” “HIV,” “HPV,” “COVID‐19,” “influenza,” and “diarrhea.” The semantic analysis identified “age” as a key term across infection, control, and intervention discussions. Notably, the relationship between “hand” and “handwashing” was prominent, especially in educational contexts linked with “school” and “absence.” Latent Dirichlet Allocation (LDA) topic modeling further delineated seven topics related to infectious disease prevention for children, encompassing (1) educational programs, (2) vaccination efforts, (3) family‐level responses, (4) care for immunocompromised individuals, (5) country‐specific responses, (6) school‐based strategies, and (7) persistent threats from established infectious diseases.ConclusionThe study emphasizes the indispensable role of personalized interventions tailored for various child demographics, highlighting the pivotal contributions of both parental guidance and school participation.Clinical RelevanceThe study provides insights into the complex public health challenges associated with preventing and managing infectious diseases in children. The insights derived could inform the formulation of evidence‐based public health policies, steering practical interventions and fostering interdisciplinary synergy for holistic prevention strategies.
The frequency and reasons for missed nursing care in Australian perioperative nurses: A national survey
Authors: Gillespie Brigid M. , Harbeck Emma , Chaboyer Wendy 
Published: February 2024

AbstractAimTo describe Australian perioperative nurses' reported frequency and reasons for missed nursing care in the operating room.DesignCross‐sectional online survey conducted in March–April 2022.MethodsA census of Australian perioperative nurses who were members of a national professional body were invited to complete a survey that focussed on their reported frequency of missed nursing care and the reasons for missed nursing care in the operating room using the MISSCare Survey OR.ResultsIn all, 612 perioperative nurses completed the survey. The perioperative and intraoperative nursing care tasks reported as most frequently missed included time‐intensive tasks and communication with multiple surgical team members present. The most frequently reported reasons for missed care were staffing‐related (e.g. staff number, skill mix, fatigue and complacency) and affected teamwork. There were no significant differences in the frequency of missed care based on perioperative nurse roles. However, there were statistically significant differences between nurse management, circulating/instrument nurses and recovery room nurses in reasons for missed care.ConclusionsMuch of the missed care that occurs in the operating room is related to communication practices and processes, which has implications for patient safety.Implications for the Profession and/or Patient CareUnderstanding the types of nursing care tasks being missed and the reasons for this missed care in the operating room may offer nurse managers deeper insights into potential strategies to address this situation.Reporting MethodStrengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement.Patient or Public ContributionNo patient or public contribution.
Begging calls and mouth colouration as predictors of breeding success in blue tits
Authors: Melero‐Romero P. , Garrido‐Bautista J. , Pérez‐Rodríguez L. , Ramos J. A. , Norte A. C. , Moreno‐Rueda G. 
Published: February 2024

AbstractNestlings normally exhibit a mix of traits that attract parental care, such as postural and vocal begging and carotenoid‐based mouth colouration. These signals are hypothesised to be signs of nestling needs (vocal begging) and quality (mouth colouration). Therefore, we hypothesised that broods, where nestlings beg for less time and display more saturated carotenoid‐based mouth colouration, would have lower nestling mortality. We tested these predictions in two wild blue tit (Cyanistes caeruleus) populations. The breeding success (here defined as the proportion of eggs that produced fledglings) was related to nestling mouth flanges' carotenoid‐based colour saturation. This means that blue tits that raised nestlings with more coloured flanges had a higher within‐population breeding success. Time spent in vocal begging, by contrast, was not associated with breeding success. Hence, our findings reveal that some communication signals displayed by nestlings (carotenoid‐based colouration) predict breeding success, in our study mostly reflecting the proportion of eggs that hatched, while begging intensity does not, probably because the former reflects a better maternal pre‐laying condition and nestling physiological status in the mid‐term.
Dissecting the genetic architecture of quantitative traits using genome‐wide identity‐by‐descent sharing
Authors: Fraimout Antoine , Guillaume Frédéric , Li Zitong , Sillanpää Mikko J. , Rastas Pasi , Merilä Juha 
Published: February 2024

AbstractAdditive and dominance genetic variances underlying the expression of quantitative traits are important quantities for predicting short‐term responses to selection, but they are notoriously challenging to estimate in most non‐model wild populations. Specifically, large‐sized or panmictic populations may be characterized by low variance in genetic relatedness among individuals which, in turn, can prevent accurate estimation of quantitative genetic parameters. We used estimates of genome‐wide identity‐by‐descent (IBD) sharing from autosomal SNP loci to estimate quantitative genetic parameters for ecologically important traits in nine‐spined sticklebacks (Pungitius pungitius) from a large, outbred population. Using empirical and simulated datasets, with varying sample sizes and pedigree complexity, we assessed the performance of different crossing schemes in estimating additive genetic variance and heritability for all traits. We found that low variance in relatedness characteristic of wild outbred populations with high migration rate can impair the estimation of quantitative genetic parameters and bias heritability estimates downwards. On the other hand, the use of a half‐sib/full‐sib design allowed precise estimation of genetic variance components and revealed significant additive variance and heritability for all measured traits, with negligible dominance contributions. Genome‐partitioning and QTL mapping analyses revealed that most traits had a polygenic basis and were controlled by genes at multiple chromosomes. Furthermore, different QTL contributed to variation in the same traits in different populations suggesting heterogeneous underpinnings of parallel evolution at the phenotypic level. Our results provide important guidelines for future studies aimed at estimating adaptive potential in the wild, particularly for those conducted in outbred large‐sized populations.
Lay theories of place effects
Authors: Borwein Sophie , Lucas Jack , Anderson Cameron 
Published: February 2024

AbstractCombining research in political geography and social psychology, this article investigates lay theories of “place effects”—that is, ordinary citizens' beliefs about the effects that urban or rural places have on the individuals who live in them. We do so using a novel survey vignette embedded in a large‐scale survey of the Canadian public. Our results suggest that (1) citizens see rural identities as less malleable than urban identities, (2) lay theories of place effects depend on citizens' own place identities, and (3) lay theories of place effects are stronger for nonpolitical than for political place‐based characteristics. We also find that lay theories of place effects are associated with individual‐level characteristics that are connected to cosmopolitan‐communitarian divides, such as ideology and postsecondary education. We conclude with a discussion of the implications of our findings for the growing literature on urban–rural divides and for research on citizens' implicit theories of places and their political consequences.
Heterogeneity in the risk of cardiovascular disease mortality after the hypertensive disorders of pregnancy across mothers' lifetime reproductive history
Authors: Wyatt Sage , Kvalvik Liv Grimstvedt , Singh Aditi , Klungsøyr Kari , Østbye Truls , Skjærven Rolv 
Published: February 2024

AbstractBackgroundPrior studies on maternal cardiovascular disease (CVD) mortality and hypertensive disorders of pregnancy (HDP) have focused only on a woman's first birth and have not accounted for successive affected pregnancies.ObjectivesThe objective of this study is to identify mothers' risk of CVD mortality considering lifetime reproductive history.MethodsWe used data from the Medical Birth Registry of Norway, the Norwegian Cause of Death Registry, and the Norwegian National Population Register to identify all mothers who gave birth from 1967 to 2020. Our outcome was mothers' CVD death before age 70. The primary exposure was the lifetime history of HDP. The secondary exposure was the order of HDP and gestational age at delivery of pregnancies with HDP. We used Cox regression models to estimate hazard ratio (HR) and 95% confidence interval (CI), adjusting for education, mother's age, and year of last birth. These models were stratified by the lifetime number of births.ResultsAmong 987,378 mothers, 86,294 had HDP in at least one birth. The highest CVD mortality, relative to mothers without HDP, was among those with a pre‐term HDP in their first two births, although this represented 1.0% of mothers with HDP (HR 5.12, 95% CI 2.66, 9.86). Multiparous mothers with term HDP in their first birth only had no increased risk of CVD relative to mothers without HDP (36.9% of all mothers with HDP; HR 1.12, 95% CI 0.95, 1.32). All other mothers with HDP had a 1.5‐ to 4‐fold increased risk of CVD mortality.ConclusionsThis study identified heterogeneity in the risk of CVD mortality among mothers with a history of HDP. A third of these mothers are not at higher risk compared to women without HDP, while some less common patterns of HDP history are associated with severe risk of CVD mortality.
Genome‐wide identification of DREB1 transcription factors in perennial ryegrass and functional profiling of LpDREB1H2 in response to cold stress
Authors: Wang Weiliang , Sun Tianxiao , Fang Zhengfu , Yang Di , Wang Yanping , Xiang Lin , Chan Zhulong 
Published: February 2024

AbstractPerennial ryegrass (Lolium perenne L.) is an outstanding turfgrass and forage cultivated in temperate regions worldwide. However, poor tolerance to extreme cold, heat, or drought limits wide extension and cultivation. DEHYDRATION‐RESPONSIVE ELEMENT BINDING FACTOR1s (DREB1s) play a vital role in enhancing plant tolerance to abiotic stress, specifically for low‐temperature stress. In this study, a total of 24 LpDREB1 family members were identified from the released genome of perennial ryegrass. Phylogenetic analysis showed that the LpDREB1 genes are divided into 7 groups that have close relationships with rice homologues. Conserved motif analysis revealed that members within the same group have similar conserved motif compositions. All LpDREB1s lack introns, and the promoter sequences of LpDREB1 genes contain multiple cis‐acting elements associated with stress response, phytohormone signal transduction and plant growth and development. The majority of LpDREB1 genes were upregulated by drought, submergence, heat and cold stress treatments, including LpDREB1H2. Further investigation showed that LpDREB1H2 is localized in the nucleus. Overexpression of LpDREB1H2 in Arabidopsis induced the expression of cold‐responsive (COR) genes, increased the levels of osmotic adjusting substances, and enhanced antioxidant enzyme activities, thus improving the cold tolerance of Arabidopsis. This study lays a foundation for further understanding the function of LpDREB1 genes in perennial ryegrass and provides insights for plant stress tolerance breeding.
The effect of nitrogen source and levels on hybrid aspen tree physiology and wood formation
Authors: Renström Anna , Choudhary Shruti , Gandla Madhavi Latha , Jönsson Leif J. , Hedenström Mattias , Jämtgård Sandra , Tuominen Hannele 
Published: February 2024

AbstractNitrogen can be taken up by trees in the form of nitrate, ammonium and amino acids, but the influence of the different forms on tree growth and development is poorly understood in angiosperm species like Populus. We studied the effects of both organic and inorganic forms of nitrogen on growth and wood formation of hybrid aspen trees in experimental conditions that allowed growth under four distinct steady‐state nitrogen levels. Increased nitrogen availability had a positive influence on biomass accumulation and the radial dimensions of both xylem vessels and fibers, and a negative influence on wood density. An optimal level of nitrogen availability was identified where increases in biomass accumulation outweighed decreases in wood density. None of these responses depended on the source of nitrogen except for shoot biomass accumulation, which was stimulated more by treatments complemented with nitrate than by ammonium alone or the organic source arginine. The most striking difference between the nitrogen sources was the effect on lignin composition, whereby the abundance of H‐type lignin increased only in the presence of nitrate. The differential effect of nitrate is possibly related to the well‐known role of nitrate as a signaling compound. RNA‐sequencing revealed that while the lignin‐biosynthetic genes did not significantly (FDR <0.01) respond to added NO3−, the expression of several laccases, catalysing lignin polymerization, was dependent on N‐availability. These results reveal a unique role of nitrate in wood formation and contribute to the knowledge basis for decision‐making in utilizing hybrid aspen as a bioresource.
Fasting and its implications for fish welfare in Atlantic salmon aquaculture
Authors: Hvas Malthe , Kolarevic Jelena , Noble Chris , Oppedal Frode , Stien Lars Helge 
Published: February 2024

AbstractPeriods of fasting occur for a multitude of reasons in Atlantic salmon aquaculture. Feed withdrawal is widely used prior to transport, parasite treatments, preslaughter and for depuration purposes in recirculating aquaculture systems. Voluntary fasting is a coping response when fish have poor health or are exposed to poor farm environments. Owing to increased attention to animal welfare in aquaculture, concerns have been raised regarding ethical issues when farmed fish are subjected to fasting. However, thorough science‐based recommendations for fasting and feed‐withdrawal regimes have been lacking. The purpose of this review is to provide a synthesis of the various causes for fasting in Atlantic salmon aquaculture and evaluate their associated welfare implications so that guidelines for appropriate practices can be formulated. To interpret impacts, we describe biological responses and tolerance limits to fasting in Atlantic salmon and consider adaptations in the wild. Fry and parr are highly sensitive to feed withdrawal. However, post‐smolts and adults are well‐adapted to endure prolonged fasting without experiencing compromised functionality or health. Here, short periods of feed withdrawal prior to operations should therefore not constitute significant welfare concerns. Serious concerns are instead associated with voluntary fasting that may continue for weeks. We emphasize that environmental extremes that exceed appetite impairing thresholds must be avoided. Additionally, farmed fish should not be subjected to practices that lead to chronic stress that induce cessation of appetite. Diseases or parasites that impair appetite should also be mitigated. Fasting is here a symptom rather than a cause for poor welfare.
Next‐generation sequencing using tissue specimen collected with a 1.1 mm‐diameter cryoprobe in patients with lung cancer
Authors: Kim Mi‐Hyun , Kim Soo Han , Lee Geewon , Mok Jeongha , Lee Min Ki , Song Ju Sun , Eom Jung Seop 
Published: February 2024

AbstractBackground and ObjectiveNext‐generation sequencing (NGS) analysis is considered standard for lung cancer diagnosis in clinical practice. Little is known about the feasibility of NGS using tumour tissue sampled with a 1.1 mm‐diameter cryoprobe. We aimed to investigate the suitability of specimens obtained by transbronchial cryobiopsy (TBC) using a 1.1 mm‐diameter cryoprobe for NGS analysis.MethodsPatients with lung cancer who underwent TBC using a 1.1 mm‐diameter cryoprobe for NGS testing between October 2020 and April 2023 were enrolled. A 4.0‐ or 3.0 mm‐diameter bronchoscope with radial probe endobronchial ultrasound and virtual bronchoscopic navigation was used to detect peripheral lung lesions. All procedures were performed under fluoroscopic guidance. Data were analysed retrospectively.ResultsA total of 56 patients underwent TBC using a 1.1 mm cryoprobe for NGS testing, during the study period. Most patients (98%) were in the advanced stage of lung cancer (recurrent or inoperable disease of stages III or IV). The diagnostic yield of NGS for DNA and RNA sequencing was 95% each (53 of 56). Moderate bleeding was noted in three patients (5%) and none of the study patients developed life‐threatening complications, such as pneumothorax or lung infection.ConclusionTBC using a 1.1 mm‐diameter cryoprobe is a useful and safe tool for NGS analysis, for both DNA and RNA sequencing.image
Trajectories among recipients of social assistance in Norway: A local approach
Authors: Dahl Espen , Lorentzen Thomas , Hermansen Åsmund , Roaldsnes Andreas 
Published: February 2024

AbstractBackground and PurposeLittle scholarly attention has been paid to variations in local welfare provisions and how they frame beneficiaries’ welfare‐work trajectories. This is unfortunate since increasingly a varied menu of services is provided locally and welfare‐work trajectories unfold in a local context. The purpose of this paper is to contribute to this debate by examining the welfare‐work trajectories among young social assistance recipients in Norwegian municipalities and how they are related to the local setting and in particular the organization of the local welfare office.Data and MethodsNational registers provide longitudinal information on all young social assistance recipients (N = 4654) in 2012. Information on municipalities (N = 373) and the local labour and welfare offices (N = 399) is collected from official government sources. Welfare‐work trajectories spanning seven years are created by sequence analysis forming eight clusters. The relationship between organizational features of the labour and welfare office and trajectory clusters is modelled by means of multinomial logistic regression, after controlling for variables on the individual, the municipal, and the regional level.ResultsThe analysis shows that: (a) among the individual variables, those reflecting poor health consistently predict trajectories characterized by benefit receipt and loose attachment to the labour market; (b) variables related to the municipal level are of limited importance, and (c) variables pertaining to the organization of the labour and welfare offices play a minor role.ConclusionOnce individual, municipal, and regional labour market factors are considered, characteristics of the welfare office are of marginal significance. [Correction added on 17 September 2024, after first online publication: The Abstract and Keywords have been added in this version.]
Expression of mPGES1 and p16 in feline and human oral squamous cell carcinoma: A comparative oncology approach
Authors: Nasry Walaa Hamed Shaker , Jones Kathleen , Rodriguez‐Lecompte Juan Carlos , Tesch Marvin , Martin Chelsea K. 
Published: February 2024

AbstractComparative cancer studies help us determine if discoveries in one species apply to another. Feline and human oral squamous cell carcinoma (FOSCC and HOSCC) are invasive tumours in which inflammation and abnormal p16 expression are reported. Immunohistochemistry was used to determine the expression of p16 and microsomal prostaglandin E2 synthase 1 (mPGES1) in 42 HOSCC and 45 FOSCC samples with known expression of cyclooxygenase 2 (COX2) and cluster of differentiation 147 (CD147). High p16 expression was more common in HOSCC tumour cells compared to adjacent stroma and oral epithelium (p < .05), with a similar but statistically nonsignificant pattern in FOSCC. Interestingly, high mPGES1 expression in FOSCC was more common in the adjacent epithelium compared to the other compartments (p < .05). In HOSCC, mPGES1 was more similar between compartments but was numerically more common in the tumour compartment (p > .05). There were nominal (p > 0.05) differences in marker expression between high and low mPGES1 expressing tumours in both species, including high p16 observed more commonly in high mPGES1 tumours, and COX‐2 positive tumours being more common in low mPGES1 tumours. High CD147 HOSCC tumours were more common in the high mPGES1 HOSCC group (p < .05). In the FOSCC cohort, where there was no statistical difference in CD147 expression between high and low mPGES1 tumours, there were numerically higher CD147 cases in the high mPGES1group. Different expression patterns in FOSCC and HOSCC could be related to different risk factors. For example, p16 is a marker of papillomavirus‐driven HOSCC, but a causal relationship between papillomaviruses and FOSCC has yet to be definitively demonstrated. The significance of high P16 expression in the absence of papillomavirus infection deserves further study, and the relative contributions of COX2 and mPGES1 to tumour inflammation and progression should be explored. The findings reveal potential similarities in FOSCC and HOSCC biology, while also demonstrating differences that may relate to risk factors and pathogenesis that are unique to each species.