bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Surgical Outcomes in 5-Year-Old Patients with Repaired Unilateral Cleft Lip and Palate
Authors: Clark S. A. , Atack N. E. , Ewings P. , Hathorn I. S. , Mercer N. S. G. 
Published: September 2006

Objective: To assess the surgical outcome of 5-year-old subjects with repaired unilateral cleft lip and palate who had been operated on by a single surgeon. Design: Retrospective consecutive outcome study. Setting: The cleft lip and palate center at Frenchay Hospital, North Bristol NHS Trust, U.K. Participants: All patients born with unilateral cleft lip and palate between May 1992 and April 1998 were identified and their study models were located. Main Outcome Measures: The reasons for failing to obtain study models were recorded. The “test” study models were combined randomly with a “gold standard” set of study models to give a group of 53 for assessment purposes. These study models were assessed twice by two examiners independently using the 5-Year-Olds’ Index. The weighted kappa (κ) statistic and components of variance were used to establish the levels of agreement within and between examiners, as well as between the gold standard and the examiners. Results: Thirty sets of study models out of a possible 43 were located. The most common reason for not obtaining records was poor cooperation. More than 50% of study models were assessed as being good outcomes (Index groups 1 and 2), whereas fewer than 20% of the records were evaluated as being poor outcomes (Index groups 4 and 5). There was good inter- and intraexaminer agreement and agreement with the gold standard values. Conclusion: Study model collection in this age group can be difficult due to patient cooperation.
Molecular Modeling
Authors: Boyd Donald B. 
Published: September 2006

AbstractThe article contains sections titled:1.Definitions2.Purpose of Modeling3.Brief History4.Methodologies of Molecular Modeling4.1.Computer Graphics4.2.Databases4.3.Conformational Modeling4.4.Quantum Mechanical Modeling4.5.Force Field Modeling4.6.Statistical Modeling4.7.Homology Modeling4.8.Drug Design Modeling5.Economic AspectsMolecular modeling is used to understand the characteristics of molecules and to design new molecules in industry and elsewhere. The computer‐based techniques of molecular modeling include molecular mechanics, molecular graphics, and many other methodologies of computational chemistry. Most large research‐based companies involved in molecular science, particularly pharmaceutical companies, use molecular modeling daily.
Enzyme and Immunoassays
Authors: Miller James N. , Niessner Reinhard , Knopp Dietmar 
Published: September 2006

AbstractThe article contains sections titled:1.Enzymatic Analysis Methods1.1.Introduction1.2.Enzymes: Basic Kinetics1.3.Enzyme Assays: Practical Aspects1.3.1.General Considerations1.3.2.Spectrometric Methods1.3.3.Other Methods1.3.4.Effects of pH, Buffer, Composition, and Temperature1.3.5.Sources and Activity of Enzymes1.4.Enzyme Assays: Determination of Substrates1.4.1.General Considerations1.4.2.Determination of Glucose1.4.3.Determination of Ethanol1.5.Enzyme Assays: Determination of Inhibitors1.5.1.Inhibitors of Cholinesterase Enzymes1.5.2.Other Inhibition Methods1.6.Enzyme Assays: Determination of Activators1.6.1.Determination of Metal Ions by Metalloenzymes1.6.2.Other Activator Analyses1.7.Immobilized Enzymes1.7.1.Introduction1.7.2.Properties of Immobilized Enzymes1.7.3.Application of Immobilized Enzymes2.Immunoassays in Analytical Chemistry2.1.Introduction2.2.Polyclonal, Monoclonal, and Recombinant Antibodies2.3.Sample Conditioning2.4.Immunoassays2.4.1.Radioimmunoassay2.4.1.1.Isotopic Dilution Radioimmunoassay2.4.1.2.Immunoradiometric Assay (IRMA)2.4.2.Nonisotopic Homogeneous Immunoassay2.4.2.1.Latex Particle Agglutination Immunoassay2.4.2.2.Enzyme‐Multiplied Immunoassay Technique (EMIT)2.4.2.3.Apoenzyme Reconstitution Immunoassay System (ARIS)2.4.2.4.Fluorophore‐Labeled Homogeneous Immunoassay2.4.2.5.Homogeneous Fluorescence Polarization Immunoassay (FPIA)2.4.2.6.Homogeneous Liposome Immunoassay2.4.3.Nonisotopic Heterogeneous Immunoassay2.4.3.1.Enzyme‐Linked Immunosorbent Assay (ELISA)2.4.3.2.Sandwich Immunoassay2.4.3.3.Immunoassays using Immobilized Affinity Ligands2.4.3.4.Immunoassays with Biotin and Avidin2.4.3.5.Magnetic Particle Immunoassay2.5.Immunoaffinity Techniques2.6.Immunoassays on Test Strips and other Planar Structures2.7.Characterization and Interference2.8.Future Immunological Applications and Techniques
Metallocenes
Authors: Kaminsky Walter 
Published: September 2006

Abstract
The article contains sections titled:

1.

Introduction

2.

Polyethylene and Polypropylene

3.

Cycloolefin Copolymers

4.

Syndiotactic Polystyrene

5.

Supporting of Metallocene Catalysts

By application of metallocenes a new catalyst family has been introduced into polyolefin production, the most quickly growing market in the polymer industries. The easy modification of the metallocene catalyst structure brought about improvements in catalyst activities, comonomer incorporation, and polymer properties. It became possible to tailor in a wide range the microstructure of polyolefins such as chain length, molecular mass distribution, polypropylene tacticity, and comonomer distribution.
Ethylene/oct‐1‐ene and cycloolefin copolymers, syndiotactic or isoblock polypropylenes and syndiotactic polystyrene are some types of new industrially produced polymers. The polyolefins synthesized by metallocene catalysts show a narrow molecular mass distribution of 2 and in some cases long chain branches.
Centrifuges, Sedimenting
Authors: Axelsson Hans , Madsen Bent 
Published: September 2006

AbstractThe article contains sections titled:1.Introduction2.Fundamentals2.1.Centrifugal Sedimentation2.2.Centrifugal Sedimentation with Continuous Flow3.Centrifugal Separators with Continuous Feed3.1.General3.2.Disk‐Bowl Machines3.3.Chamber and Multichamber Bowls3.4.Tubular Bowl Centrifuges3.5.Decanter Centrifuges3.6.Other Bowl Geometries4.Batch Centrifuges4.1.General4.2.Bottle Centrifuges4.3.Batch Zonal Centrifuges5.Fluid Dynamics in Centrifuges5.1.Chamber and Tubular Bowl Centrifuges5.2.Disk‐Bowl Centrifuges5.3.Decanter Centrifuges6.Centrifuge Technology6.1.Rotor Dynamics6.2.Materials Selection7.Centrifuge Selection7.1.Introduction7.2.Main Process Parameters7.3.Test Tube Centrifugation (Spin Test)7.4.Important Properties of the Process Streams7.5.Improvement of Separability7.6.Pilot Machine Testing7.7.Scale‐Up8.Applications
Intermetallics
Authors: Sauthoff Gerhard 
Published: September 2006

AbstractThe article contains sections titled:1.Introduction1.1.Definition of Intermetallics1.2.Historical Remarks2.General Considerations2.1.Crystal Structure and Compound Stability2.2.Basic Properties2.3.Criteria for Compound Selection3.Magnetic Materials3.1.AlNiCo Alloys3.2.FeCo Alloys3.3.Sendust Alloy3.4.Laves Phases3.5.Rare‐Earth Compounds4.Superconducting Materials4.1.Laves Phases4.2.A15 Compounds4.2.1.V3Si4.2.2.V3Ga4.2.3.Nb3Sn4.2.4.Nb3Al4.2.5.Nb3Si5.Electronic Materials5.1.Silicides5.2.Other Compounds6.Electric Materials7.Thermoelectric and Thermomagnetic Materials7.1.Silicides7.2.Other Thermoelectric Compounds7.3.Thermomagnetic Compounds8.Optical Materials9.Hydrogen‐Storage Materials9.1.B2 Compounds9.2.Laves Phases9.3.Rare Earth Metal Compounds and Other Phases10.Electrode Materials10.1.Mg2Ni Alloys10.2.Laves Phase Alloys10.3.RNi5Alloys11.Coating Materials11.1.Aluminides11.2.Silicides12.Shape‐Memory Materials12.1.Cu‐Base Alloys12.1.1.Cu ‐ Zn ‐ Al Shape Memory Alloys12.1.2.Cu ‐ Al ‐ Ni Shape‐Memory Alloys12.2.NiAl Alloys12.3.NiTi Alloys13.Medical Biomaterials14.Dental Materials14.1.Amalgams14.2.Cu ‐ Au Alloys15.Wear‐Resistant Materials16.Structural High‐Temperature Materials16.1.Titanium Aluminide Alloys16.1.1.Ti3Al Alloys16.1.2.TiAl Alloys16.2.Iron Aluminide Alloys16.2.1.Fe3Al Alloys16.2.2.FeAl Alloys16.3.Nickel Aluminide Alloys16.3.1.Ni3Al alloys16.3.2.NiAl Alloys16.4.Silicide Alloys
Cover Picture: Solution‐Processed Organic Tandem Solar Cells (Adv. Funct. Mater. 14/2006)
Authors: Hadipour A. , de Boer B. , Wildeman J. , Kooistra F. B. , Hummelen J. C. , Turbiez M. G. R. , Wienk M. M. , Janssen R. A. J. , Blom P. W. M. 
Published: September 2006

AbstractThe fabrication of a solution‐processed polymer tandem cell by stacking two single cells in series is reported by de Boer and co‐workers on p. 1897. The bottom and top cell are complementary with respect to their absorption spectra and the layer thickness of the bottom cell was optimized in order to create an optical cavity that efficiently transmits the required wavelength for the top cell. The combination of this tandem architecture with more efficient small‐bandgap materials will enable the realization of highly efficient organic solar cells.A solution‐processed polymer tandem cell fabricated by stacking two single cells in series is demonstrated. The two bulk‐heterojunction subcells have complementary absorption maxima at λmax ∼ 850 nm and λmax ∼ 550 nm, respectively. A composite middle electrode is applied that serves both as a charge‐recombination center and as a protecting layer for the first cell during spin‐coating of the second cell. The subcells are electronically coupled in series, which leads to a high open‐circuit voltage of 1.4 V, equal to the sum of each subcell. The layer thickness of the first (bottom) cell is tuned to maximize the optical absorption of the second (top) cell. The performance of the tandem cell is presently limited by the relatively low photocurrent generation in the small‐bandgap polymer of the top cell. The combination of our tandem architecture with more efficient small‐bandgap materials will enable the realization of highly efficient organic solar cells in the near future.
Cover Picture: A Single Polymer Nanowire Photodetector (Adv. Mater. 18/2006)
Authors: O'Brien G. A. , Quinn A. J. , Tanner D. A. , Redmond G. 
Published: September 2006

AbstractRedmond and co‐workers report on p. 2379 the successful application of solution‐assisted template wetting to the high‐yield controlled synthesis of poly[(9,9‐dioctylfluorenyl‐2,7‐diyl)‐co‐(bithiophene)] (F8T2) nanowires (main picture and lower inset). Photoconductivity measurements (schematic in center) yield single‐nanowire device responsivities of ca. 0.4 mA W–1 and external quantum efficiencies of ca. 0.1 % under monochromatic illumination, comparable with data reported for single inorganic nanowire devices.
The One‐Pot Wittig Reaction: A Facile Synthesis of α,β‐Unsaturated Esters and Nitriles by Using Nanocrystalline Magnesium Oxide
Authors: Choudary Boyapati M. , Mahendar Koosam , Kantam M. Lakshmi , Ranganath Kalluri V. S. , Athar Taimur 
Published: September 2006

AbstractNanocrystalline magnesium oxide was found to be an effective heterogeneous, solid base catalyst for the one‐pot Wittig reaction to afford α,β‐unsaturated esters and nitriles in excellent yields with high E‐stereoselectivity in the presence of triphenylphosphine under mild conditions.
Pyridin‐, Quinolin‐ and Acridinylidene Palladium Carbene Complexes as Highly Efficient C–C Coupling Catalysts
Authors: Schneider Sabine K. , Roembke Patric , Julius Gerrit R. , Raubenheimer Helgard G. , Herrmann Wolfgang A. 
Published: September 2006

AbstractA series of four new complexes bearing N‐heterocyclic carbene ligands (NHCs) as well as four compounds bearing N‐heterocyclic carbene ligands with remote heteroatoms (rNHCs) of the general types [(NHC)(PPh3)2PdCl]+BF4− and [(rNHC)(PPh3)2PdCl]+BF4−, respectively, have been prepared in high yields. Crystal and molecular structures have been determined for four representative examples. These compounds proved to be efficient catalysts for aryl coupling reactions of the Heck and Suzuki types (reaching TONs of as high as 6,200,000). Both aryl bromides and aryl chlorides can be used as substrates. Like the well known mixed, standard (NHC)(phosphine) compounds, the new six‐numbered, one‐N‐heterocyclic carbene complexes (and in particular certain rNHC‐containing ones) also combine the advantageous stability of bis(carbene) and the high activity of bis(phosphine) complexes. Furthermore, their good catalytic performance and, especially, their easy synthesis based on cheap and commercially available starting materials, make them by far superior when compared to the mixed (NHC)(phosphine) catalysts known thus far.
Direct Coupling Reactions of Alkynylsilanes Catalyzed by Palladium(II) Chloride and a Di(2‐pyridyl)methylamine‐Derived Palladium(II) Chloride Complex in Water and in NMP
Authors: Gil‐Moltó Juan , Nájera Carmen 
Published: September 2006

AbstractSymmetrical internal alkynes can be prepared either by diarylation of mono‐ and bis(trimethylsilyl)acetylene (TMSA and BTMSA) catalyzed by ligand‐less palladium(II) chloride or by a di(2‐pyridyl)methylamine‐derived palladium(II) chloride complex 1 (typical 0.1–1 mol % of Pd loading) in water using pyrrolidine as base and tetra‐n‐butylammonium bromide as additive. Alternatively, this same process is performed in NMP in the presence of tetra‐n‐butylammonium acetate (TBAA) as base with even lower Pd loadings (0.001–1 mol % Pd). The same reaction conditions are applied to the synthesis of unsymmetrical internal alkynes by monoarylation of silylated terminal alkynes. Aryl iodides can be coupled with TMSA, BTMSA and silylated terminal alkynes under heating or at room temperature, whereas for aryl bromides couplings are performed under water reflux or at 110 °C in the case of NMP. Complex 1 can be reused during several cycles either in water or in NMP without loss of catalytic activity. These simple reaction conditions allow the preparation of internal alkynes without secondary products, most probably by succesive protiodesilylation‐Sonogashira coupling.
A Convenient and Highly Productive Aminohydroxylation Protocol Employing an Osmium‐Diamine Catalyst
Authors: Muñiz Kilian , Almodovar Iriux , Streuff Jan , Nieger Martin 
Published: September 2006

AbstractIn situ generated osmium‐diamine chelates from 2,3‐diaminopropionic acid or diaminosuccinic acid represent efficient catalysts for the highly productive aminohydroxylation of alkenes. The reaction can be employed with various osmium salts and successful catalyst recycling was demonstrated for a representative example. The catalyst design derives from the general structural features of recently investigated osmium complexes from alkene diamination reactions.
Highly Enantioselective Catalytic Alkynylation of Ketones – A Convenient Approach to Optically Active Propargylic Alcohols
Authors: Lu Gui , Li Xingshu , Li Yue‐Ming , Kwong Fuk Yee , Chan Albert S. C. 
Published: September 2006

AbstractThe development of highly enantioselective catalysts involving Cu(OTf)2 and chiral camphorsulfonamides for the alkynylation of ketone is described. The influences of Lewis acids, reaction conditions and chiral ligands on the outcome of the reaction are discussed. The best enantioselectivity (up to 97 % ee) was obtained in the alkynylation of 2′‐chloroacetophenone. The scope of the reaction is also examined.
Recyclable Selective Palladium‐Catalyzed Synthesis of Five‐, Six‐ or Seven‐Membered Ring Lactones and Lactams by Cyclocarbonylation in Ionic Liquids
Authors: Ye Fangguo , Alper Howard 
Published: September 2006

AbstractThe ionic liquids, BMIM PF6 or BMIM NTf2, are used successfully for the palladium‐catalyzed cyclocarbonylation of 2‐allylphenols and anilines, 2‐vinylphenols, and 2‐aminostyrenes. The reaction proceeds cleanly and efficiently to afford high yields of lactones or lactams with good or excellent selectivity for one isomer. The ionic liquid containing the palladium catalyst, and ligand, is recyclable in all cases.
Organocatalytic and Stereoselective [3 + 2] Cycloadditions of Azomethine Imines with α,β‐Unsaturated Aldehydes
Authors: Chen Wei , Yuan Xiang‐Hong , Li Rui , Du Wei , Wu Yong , Ding Li‐Sheng , Chen Ying‐Chun 
Published: September 2006

AbstractBipyrazolidin‐3‐one derivatives are biologically significant compounds and their importance has increased in the past decades. In this paper, the first stereoselective [3 + 2] dipolar cycloadditions of azomethine imines with α,β‐unsaturated aldehydes catalyzed by readily available α,α‐diarylprolinol salts are reported, providing a facile route to the synthesis of various chiral bipyrazolidin‐3‐one derivatives under mild conditions. The organocatalyst 1 g with strongly electron‐withdrawing groups exhibited the best stereoselectivity (exo:endo up to 98:2, for exo product up to 97 % ee), in the combination with trifluoroacetic acid.
Efficient Enantioselective Hydrosilylation of Aryl Ketones Catalyzed by a Chiral BINAP‐Copper(I) Catalyst‐Phenyl(methyl)silane System
Authors: Issenhuth Jean Thomas , Dagorne Samuel , Bellemin‐Laponnaz Stéphane 
Published: September 2006

AbstractThe Cu(I)‐chiral diphosphine (BINAP) system was found to efficiently catalyze the hydrosilylation of aryl alkyl ketones with excellent enantioselectivities by using phenyl(methyl)silane as stoichiometric hydride source.
An Efficient Intramolecular Stetter Reaction in Room Temperature Ionic Liquids Promoted By Microwave Irradiation
Authors: Zhou Zhong‐Zhen , Ji Feng‐Qing , Cao Min , Yang Guang‐Fu 
Published: September 2006

AbstractThis communication describes the first report of a microwave‐assisted intramolecular Stetter reaction using imidazolium‐type room temperature ionic liquids (RTILs) as solvents, with thiazolium salts and Et3N as catalysts. The features such as good to excellent yields, shorter reaction time (5–20 min), and recyclable and reusable ionic liquid and catalyst make this method an environmentally benign and highly efficient procedure for the preparation of chromanone derivatives.
An Efficient Bismuth(III) Chloride‐Catalyzed Synthesis of 1,1‐Diarylalkenes via Friedel–Crafts Reaction of Acyl Chloride or Vinyl Chloride with Arenes
Authors: Sun Hongbin , Hua Ruimao , Chen Songjie , Yin Yingwu 
Published: September 2006

AbstractIn the presence of catalytic amount of bismuth(III) chloride, the reactions of acyl chlorides or vinyl chlorides with arenes afforded 1,1‐diarylalkenes in 25–82 % isolated yield. In the case of the reaction of acyl chlorides with arenes, the procedure includes an initial Friedel–Crafts acylation, subsequent formation of vinyl chlorides and final Friedel–Crafts‐type vinylation of another arene molecule with vinyl chloride. This paper reports the first Lewis acid‐catalyzed cleavage of the CCl bond of vinyl chloride and its application in the synthesis of multiply subtituted alkenes.
From a Racemate to a Single Enantiomer: Deracemization by Stereoinversion
Authors: Gruber Christian C. , Lavandera Iván , Faber Kurt , Kroutil Wolfgang 
Published: September 2006

AbstractThe stereoinversion of one enantiomer into its mirror‐image counterpart within a racemate furnishes a single stereoisomeric product in 100 % theoretical yield. This extremely efficient type of deracemization, whereby substrate and product possess an identical chemical structure, can be achieved by using bio‐ or chemo‐catalysts or combinations thereof and is applicable to secondary alcohols, amines and α‐substituted carboxylic acids. Special emphasis is devoted to the theoretical background of the one‐pot, single‐step deracemization of sec‐alcohols.
New Heterogenized Gold(I)‐Heterocyclic Carbene Complexes as Reusable Catalysts in Hydrogenation and Cross‐Coupling Reactions
Authors: Corma A. , Gutiérrez‐Puebla E. , Iglesias M. , Monge A. , Pérez‐Ferreras S. , Sánchez F. 
Published: September 2006

AbstractMononuclear unsymmetrical N‐heterocyclic carbene‐gold complexes and the corresponding solid catalysts in which a gold‐carbene complex has been immobilized on silica gel, ordered mesoporous silica (MCM‐41), and delaminated zeolite (ITQ‐2) have been prepared. These new catalysts have been tested in the hydrogenation of alkenes and the Suzuki cross‐coupling reaction to afford selectively non‐symmetrical biaryls. These reactions were studied with the soluble as well as with the heterogenized counterpart catalysts. The high accessibility introduced by the structure of the supports allows the preparation of highly efficient immobilized catalysts with TOFs up to 400 h−1. Moreover, the heterogenized complexes were reused and no deactivation of the catalysts can be observed.
Enzymatic Transformations 62. Preparative Scale Synthesis of Enantiopure Glycidyl Acetals using an Aspergillus niger Epoxide Hydrolase‐Catalysed Kinetic Resolution
Authors: Doumèche Bastien , Archelas Alain , Furstoss Roland 
Published: September 2006

AbstractThe hydrolytic kinetic resolution of five glycidaldehyde acetal derivatives was examined using the recombinant Aspergillus niger epoxide hydrolase as biocatalyst. This could successfully be performed, at room temperature, using solely demineralised water as solvent and following a two‐phase methodology allowing us to operate at a global substrate concentration as high as 200 g/L in the reactor. The observed E values were shown to be modest to excellent, depending on the structure of the acetal moiety, indicating that it is possible to achieve this resolution very efficiently just by choosing the right substituents. Both the unreacted (R)‐epoxide and the formed (S)‐diol could thus be obtained in good to excellent ee (ee>99 % for the epoxide). For the best substrates, the reaction could be performed within a few hours by using a biocatalyst over substrate molecular ratio of about 9 to 10×10−4 mol %. The turnover frequency (TOF) as well as the total turnover number (TON) of the enzyme proved to be excellent as compared to chemical catalysts – reaching respectively values in the order of 6×102 mol sub/mol enz/min and 6×104 mol sub/mol enz. The space‐time yield of the best (two‐phase) reactor could thus reach a value as high as 56 g/L/hour. As a demonstration experiment, a 50‐g scale resolution of glycidaldehyde 2,2‐dimethyltrimethylene acetal was performed.
Hydrophilic CNC‐Pincer Palladium Complexes: A Source for Highly Efficient, Recyclable Homogeneous Catalysts in Suzuki–Miyaura Cross‐Coupling
Authors: Churruca Fátima , SanMartin Raul , Inés Blanca , Tellitu Imanol , Domínguez Esther 
Published: September 2006

AbstractThe Suzuki biaryl coupling of a range of electronically dissimilar arylboronic acids and aryl bromides is performed in neat water with excellent to quantitative yields by means of a new CNC‐pincer palladium catalyst that is soluble in water due to its para‐carboxy group. Extremely high turnover numbers and frequencies combined with a remarkable robustness allow an effective catalyst reuse in sustainable conditions.
A 100 Gram‐Scale Production of a Key Building Block of Antibacterial Vancomycin: The Use of an Air‐Stable Chiral Zirconium Catalyst and Complete Recovery of a Silicon Source in Catalytic Asymmetric Mukaiyama Aldol Reaction
Authors: Isoda Takeshi , Akiyama Ryo , Oyamada Hidekazu , Kobayashi Shū 
Published: September 2006

AbstractWe have achieved a 100 gram‐scale production of anti‐(2S,3S)‐β‐(p‐benzyloxy‐m‐chloro)phenyl‐N‐trifluoroacetyl‐L‐serine methyl ester (1) in high yield with high diastereo‐ and enantioselectivities based on a catalytic asymmetric Mukaiyama aldol reaction. The use of an air‐stable zirconium‐molecular sieves combined catalyst [(R)‐I4‐ZrMS] facilitates easy manufacturing operation and reproducibility. Moreover, this is the first example of the complete recovery of the silicon source in a Mukaiyama aldol reaction.
Brønsted Acid‐Catalyzed Nucleophilic Substitution of Alcohols
Authors: Sanz Roberto , Martínez Alberto , Miguel Delia , Álvarez‐Gutiérrez Julia M. , Rodríguez Félix 
Published: September 2006

AbstractSimple Brønsted acids such as p‐toluenesulfonic acid monohydrate (PTS) or polymer‐bound p‐toluenesulfonic acid efficiently catalyze the direct nucleophilic substitution of the hydroxy group of allylic and benzylic alcohols with a large variety of carbon‐ and heteroatom‐centered nucleophiles. Reaction conditions are mild, the process is conducted under an atmosphere of air without the need for dried solvents, and water is the only side product of the reaction.