bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antineoplastic effect of compounds C14 and P8 on TNBC and radioresistant TNBC cells by stabilizing the K-Ras4BG13D/PDE6δ complex
Authors: Carrión-Estrada Dayan A. , Aguilar-Rojas Arturo , Huerta-Yepez Sara , Montecillo-Aguado Mayra , Bello Martiniano , Rojo-Domínguez Arturo , Arechaga-Ocampo Elena , Briseño-Díaz Paola , Meraz-Ríos Marco Antonio , Thompson-Bonilla María del Rocío , Hernández-Rivas Rosaura , Vargas Miguel 
Published: March 2024

IntroductionBreast cancer (BC) is the leading cause of cancer-related deaths among women, with triple-negative breast cancer (TNBC) representing one of the most aggressive and treatment-resistant subtypes. In this study, we aimed to evaluate the antitumor potential of C14 and P8 molecules in both TNBC and radioresistant TNBC cells. These compounds were chosen for their ability to stabilize the complex formed by the overactivated form of K-Ras4BG13D and its membrane transporter (PDE6δ).MethodsThe antitumor potential of C14 and P8 was assessed using TNBC cell lines, MDA-MB-231, and the radioresistant derivative MDA-MB-231RR, both carrying the K-Ras4B&gt;
G13D mutation. We investigated the compounds' effects on K-Ras signaling pathways, cell viability, and tumor growth in vivo.ResultsWestern blotting analysis determined the negative impact of C14 and P8 on the activation of mutant K-Ras signaling pathways in MDA-MB-231 and MDA-MB-231RR cells. Proliferation assays demonstrated their efficacy as cytotoxic agents against K-RasG13D mutant cancer cells and in inducing apoptosis. Clonogenic assays proven their ability to inhibit TNBC and radioresistant TNBC cell clonogenicity. In In vivo studies, C14 and P8 inhibited tumor growth and reduced proliferation, angiogenesis, and cell cycle progression markers.DiscussionThese findings suggest that C14 and P8 could serve as promising adjuvant treatments for TNBC, particularly for non-responders to standard therapies. By targeting overactivated K-Ras and its membrane transporter, these compounds offer potential therapeutic benefits against TNBC, including its radioresistant form. Further research and clinical trials are warranted to validate their efficacy and safety as novel TNBC treatments.
NUP214 fusion genes in acute leukemias: genetic characterization of rare cases
Authors: Brunetti Marta , Andersen Kristin , Spetalen Signe , Lenartova Andrea , Osnes Liv Toril Nygård , Vålerhaugen Helen , Heim Sverre , Micci Francesca 
Published: March 2024

IntroductionAlterations of the NUP214 gene (9q34) are recurrent in acute leukemias. Rearrangements of chromosomal band 9q34 targeting this locus can be karyotypically distinct, for example t(6;9)(p22;q34)/DEK::NUP214, or cryptic, in which case no visible change of 9q34 is seen by chromosome banding.MethodsWe examined 9 cases of acute leukemia with NUP214 rearrangement by array Comparative Genomic Hybridization (aCGH), reverse-transcription polymerase chain reaction (RT-PCR), and cycle sequencing/Sanger sequencing to detect which fusion genes had been generated.ResultsThe chimeras DEK::NUP214, SET::NUP214, and NUP214::ABL1 were found, only the first of which can be readily detected by karyotyping.DiscussionThe identification of a specific NUP214 rearrangement is fundamental in the management of these patients, i.e., AMLs with DEK::NUP214 are classified as an adverse risk group and might be considered for allogenic transplant. Genome- and/or transcriptome-based next generation sequencing (NGS) techniques can be used to screen for these fusions, but we hereby present an alternative, step-wise procedure to detect these rearrangements.
Children with non-central nervous system tumors treated with platinum-based chemotherapy are at risk for hearing loss and cognitive impairments
Authors: L’Hotta Allison J. , Spence Anne , Varughese Taniya E. , Felts Kara , Hayashi Susan S. , Jones-White Megan , LaFentres Emily , Lieu Judith E. C. , Hayashi Robert J. , King Allison A. 
Published: March 2024

BackgroundChildhood cancer survivors (CCS) with chemotherapy induced sensorineural hearing loss (SNHL) are at risk for neurocognitive impairments. The purpose of this study was to determine the relationship between SNHL and cognitive function among CCS.ProcedureInclusion: non-CNS solid tumor diagnosis; history of platinum chemotherapy (cisplatin and/or carboplatin); 8–17 years of age; off anti-cancer treatment for ≥6 months; and English speaking. Exclusion: history of intrathecal chemotherapy, cranial radiation, or baseline neurocognitive disorder. Participants completed the NIH Toolbox Cognition Battery at enrollment. T-tests were used to compare participants with normal hearing to those with hearing loss and the total sample with established Toolbox normative data (mean: 50; SD: 10).ResultsFifty-seven individuals enrolled; 52 completed full cognitive testing. Participants were on average 12.2 years of age and 7.0 years since treatment completion. Twenty-one participants (40%) received cisplatin, 27 (52%) carboplatin, and 4 (8%) received both. Fifteen participants (29%) demonstrated SNHL based on the better ear. CCS, regardless of the presence or absence of SNHL, demonstrated significantly lower mean cognitive skills compared to the normative sample in attention, executive function, language- vocabulary and oral reading, processing speed, and fluid, crystallized and total composite scores (all p &lt; 0.01). Participants with SNHL had significantly lower crystallized composite (vocabulary, oral reading) than those with normal hearing (41.9 vs. 47.2, p &lt; 0.05, Cohen's d = 0.62).ConclusionsCCS at risk for platinum induced hearing loss but without cranial radiation or intrathecal chemotherapy exposure demonstrate impaired cognitive skills and those with SNHL demonstrate lower crystallized composite scores.
Skin-to-skin transfer from the delivery room to the neonatal unit for neonates of 1,500g or above: a feasibility and safety study
Authors: M’Rini Meline , De Doncker Loïc , Huet Emilie , Rochez Céline , Kelen Dorottya 
Published: March 2024

ObjectiveImmediate skin-to-skin contact (SSC) is already standard care for healthy term newborns, but its use for term or preterm newborns requiring admission to neonatal intensive care unit (NICU) with or without respiratory support is challenging. This study aimed to assess the safety and feasibility of SSC during the transfer of newborn infants, using a new purpose-built mobile shuttle care-station, called “Tandem”.Material and methodsA monocentric prospective observational study was conducted at the tertiary referral center of the Université libre de Bruxelles in Brussels, Belgium after ethical approval by Hopital Erasme's Ethics Committee (ClinicalTrials.gov ID: NCT06198478). Infants born with a birth weight above 1,500 g were included. Following initial stabilization, infants were placed in SSC with one of their parents and transferred to the NICU using the Tandem.ResultsOut of 65 infants initially included, 64 (98.5%) were successfully transported via SSC using the Tandem. One transfer was not successful due to last minute parental consent withdrawal. The median (range) duration of continuous skin-to-skin contact after birth was 120 min (10–360). SSC transfers were associated with gradually decreasing heart rate (HR) values, stable oxygen saturation levels (SpO2), and no increase in median fraction of inspired oxygen (FiO2). Heatloss was predominantly observed during initial setup of SSC. There was no significant difference in the occurrence of tachycardia, desaturation or hypothermia between preterm and term neonates. No equipment failures compromising the transfer were recorded.ConclusionSkin-to-skin transfer of infants with a birthweight of equal or above 1,500 g using the Tandem shuttle is feasible and associated with stable physiological parameters. This method facilitates early bonding and satisfies parents.Clinical Trial RegistrationClinicalTrials.gov (NCT06198478).
Causal relationship between physical activity and platelet traits: a Mendelian randomization study
Authors: Jia Mingyuan , Wang Zhiyong , Hu Fengting 
Published: March 2024

Introduction: The purpose of this study was to discuss the causal relationship between physical activity and platelet traits.Methods: A dataset from a large-scale European physical activity and platelet traits was collected by using Mendelian randomization of the study. For the analysis, the inverse variance weighting method, weighted median and MR-Egger were used to estimate causal effects. The sensitivity analyses were also performed using Cochran’s Q test, funnel plots and Leave-one-out analysis.Results: Light DIY, other exercises, strenuous sports, walking for pleasure were significantly associated with a decrease in platelet crit. But none of the heavy /light DIY was associated with increase in platelet crit. Other exercises and strenuous sports were associated with decrease in platelet count.Conclusion: Some types of physical activity have a causal relationship with platelet crit and platelet count. However, the types of physical activity we studied have not supported a causal relationship with mean platelet volume and platelet distribution width.
The struggle within dual systems of government: dealing with conflict between traditional leaders and ward councilors in the greater Giyani Municipality in South Africa
Authors: Muchaku Shadreck , Magaiza Grey 
Published: March 2024

IntroductionCurrent frameworks of conflict resolution have shown only partial success, particularly in the context of local municipalities where conflicts persist. There is a pressing need for context-specific framework that address leadership conflicts while fostering peace.MethodsTo address the lack of progress in resolving conflicts, this study identifies major challenges undermining the assimilation and implementation of objectively informed conflict resolution strategies. A purposive sampling method was employed to select 33 respondents from the Greater Giyani Municipality. Data were collected through semistructured interviews and analyzed using statistically established matrix scoring procedures. ATLAS.ti software was utilized for data analysis.ResultsWithout claiming to be exhaustive, this paper highlights examples of externalities that threaten the coexistence of the dual system of governance in South African communities, with a focus on leadership conflict and unsustainable peace. Factors contributing to conflict escalation include capacity constraints, lack of inclusive, bias, divisive decision-making and contested court decisions.DiscussionThe study underscores the importance of addressing these challenges to foster effective conflict resolution. It emphasizes the need for the scientific community to provide critical information necessary for responding effectively to these challenges.ConclusionTo enhance conflict resolution in local municipalities, it is imperative to develop context-specific frameworks that address underlying challenges and promote sustainable peace. This requires concerted efforts from both researchers and practitioners to provide the necessary insights and strategies for resolution.
Implementing machine learning techniques for continuous emotion prediction from uniformly segmented voice recordings
Authors: Diemerling Hannes , Stresemann Leonie , Braun Tina , von Oertzen Timo 
Published: March 2024

IntroductionEmotional recognition from audio recordings is a rapidly advancing field, with significant implications for artificial intelligence and human-computer interaction. This study introduces a novel method for detecting emotions from short, 1.5 s audio samples, aiming to improve accuracy and efficiency in emotion recognition technologies.MethodsWe utilized 1,510 unique audio samples from two databases in German and English to train our models. We extracted various features for emotion prediction, employing Deep Neural Networks (DNN) for general feature analysis, Convolutional Neural Networks (CNN) for spectrogram analysis, and a hybrid model combining both approaches (C-DNN). The study addressed challenges associated with dataset heterogeneity, language differences, and the complexities of audio sample trimming.ResultsOur models demonstrated accuracy significantly surpassing random guessing, aligning closely with human evaluative benchmarks. This indicates the effectiveness of our approach in recognizing emotional states from brief audio clips.DiscussionDespite the challenges of integrating diverse datasets and managing short audio samples, our findings suggest considerable potential for this methodology in real-time emotion detection from continuous speech. This could contribute to improving the emotional intelligence of AI and its applications in various areas.
Changes in mental health levels among Chinese athletes from 1995 to 2023
Authors: Xi Yue , Liu Fengbo , Yang Jian 
Published: March 2024

ObjectiveIn recent years, with the increasing intensity of sports competition and social pressure, the issue of mental health among athletes have gradually attracted attention. Understanding the changing trends of athletes’ mental health is of great significance for formulating effective intervention measures and safeguarding the mental health of athletes.MethodsA total of 306 articles were accumulated from September to November 2023 by selecting literature from databases that measured the mental health of Chinese athletes using the Symptom Checklist-90 (SCL-90). Based on the screening criteria, 28 articles (N = 4,227) were finally included. A cross-sectional historical meta-analysis of these 28 studies using the SCL-90 between 1995 and 2023 was conducted. Based on cross-sectional historical meta-analysis methods, specific statistical methods, such as correlation and regression analyses, were used to examine trends over time in the scores of the nine SCL-90 factors measured by the athletes in the studies, as well as athlete type and gender differences.Results(1) Athletes’ scores on the depression, hostility, phobic anxiety, and paranoid ideation factors gradually increased with the change of era, and the explanation rate of the variation of each factor by era ranged from 18.8 to 27.2%; (2) During the period from 1995 to 2023, the mental health of athletes in China gradually deteriorated on the factors of depression, hostility, and phobic anxiety, the rate of change was rapid, with a medium to large magnitude (0.28–0.42); (3) The scores of female athletes on the depression and psychoticism factors scores showed a significant upward trend, while male mental health scores for each factor did not improve significantly over the years; (4) College athletes’ scores on the depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychoticism factors showed an upward trend as the years changed.ConclusionChinese athletes’ mental health has been on a downward trend for the past 28 years, which needs to be a cause for concern.
Improvement of social functioning in patients with first-episode schizophrenia using blonanserin treatment: a prospective, multi-centre, single-arm clinical trial
Authors: Gao Tianqi , Deng Hong , Sheng Jianhua , Wu Bin , Liu Zhening , Yang Fude , Wang Lina , Hu Shaohua , Wang Xijin , Li Haiyun , Pu Chengcheng , Yu Xin 
Published: March 2024

ObjectivesThis clinical trial primarily aimed to investigate the effects of blonanserin on social functioning in patients with first-episode schizophrenia.MethodsIn this prospective, multi-centre, single-arm clinical trial study, blonanserin (flexible oral dose ranging from 8mg to 24mg per day) was given 26 weeks. Outcome measures included the Personal and Social Performance (PSP) scale for evaluating social functioning, the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB) for measuring neurocognitive performance, and the Positive and Negative Syndrome Scale (PANSS) for assessing symptom severity. The primary endpoint was social function improvement evaluated by PSP scale at the end of blonanserin treatment. And the secondary endpoint was to validate the efficacy and neurocognitive effects of blonanserin. Adverse drug reactions (ADRs) were also recorded and analysed.ResultsA total of 96 patients with first-episode schizophrenia were recruited and proceeded to analysis. Fifty-one participants (53.1%) completed the PSP scale measurements at baseline and week 26. Following 26 weeks of blonanserin treatment, all outcome measurements demonstrated significant improvement during the follow-up period. Notably, PSP scores exhibited a continuous increase up to 68.1% ± 103.7% at the end of the treatment (46.6 ± 14.6 at baseline, 69.4 ± 17.4 at week 26, p&lt;0.001), indicating positive effects on social functioning that were already noticeable by week 8.ConclusionBlonanserin treatment exhibited favourable effects on social functioning in individuals with first-episode schizophrenia. The results suggest that blonanserin was effective treatment options for patients with schizophrenia encountering functional impairments.
Sources of negative emotions and tactics of self-emotion regulation among college students during COVID-19 school closure in China
Authors: Fu Hai , Pan Mingfeng , Lai Mingdong 
Published: March 2024

BackgroundThis study investigated the level of anxiety and depression in Chinese college students since the COVID-19 pandemic and explored the sources of their negative emotions and students' self-emotion regulation strategies.MethodsA stratified cluster sampling questionnaire was used to survey college students during the pandemic via the Anxiety Depression, Self-made Negative Emotion Source, and Negative Emotion Regulation Strategy Scales.ResultsThe prevalence of anxiety and depression was 23.3 and 20.1%, respectively. These levels were higher in women than in men. Furthermore, senior students reported higher levels than freshmen. Anxiety and depression mainly came from the pressure to grow and the narrowed scope of social activities. Proper relaxation via entertainment and communication with family and friends were popular ways of regulating their negative emotions.ConclusionCollege students should confront their negative emotions and understand their source, use psychological methods to regulate their anxiety and depression or seek professional help, improve their psychological resilience, and adopt positive coping measures.
A cost-effective, machine learning-driven approach for screening arterial functional aging in a large-scale Chinese population
Authors: Miao Rujia , Dong Qian , Liu Xuelian , Chen Yingying , Wang Jiangang , Chen Jianwen 
Published: March 2024

IntroductionAn easily accessible and cost-free machine learning model based on prior probabilities of vascular aging enables an application to pinpoint high-risk populations before physical checks and optimize healthcare investment.MethodsA dataset containing questionnaire responses and physical measurement parameters from 77,134 adults was extracted from the electronic records of the Health Management Center at the Third Xiangya Hospital. The least absolute shrinkage and selection operator and recursive feature elimination-Lightweight Gradient Elevator were employed to select features from a pool of potential covariates. The participants were randomly divided into training (70%) and test cohorts (30%). Four machine learning algorithms were applied to build the screening models for elevated arterial stiffness (EAS), and the performance of models was evaluated by calculating the area under the receiver operating characteristic curve (AUC), sensitivity, specificity, and accuracy.ResultsFourteen easily accessible features were selected to construct the model, including “systolic blood pressure” (SBP), “age,” “waist circumference,” “history of hypertension,” “sex,” “exercise,” “awareness of normal blood pressure,” “eat fruit,” “work intensity,” “drink milk,” “eat bean products,” “smoking,” “alcohol consumption,” and “Irritableness.” The extreme gradient boosting (XGBoost) model outperformed the other three models, achieving AUC values of 0.8722 and 0.8710 in the training and test sets, respectively. The most important five features are SBP, age, waist, history of hypertension, and sex.ConclusionThe XGBoost model ideally assesses the prior probability of the current EAS in the general population. The integration of the model into primary care facilities has the potential to lower medical expenses and enhance the management of arterial aging.
Changes and interruptions during COVID-19: caregivers of people with brain health challenges—A qualitative analysis
Authors: Kennedy Polly , Rogan Carol , Higgins Dawn , Chen Yao , Grycuk Emilia , Leroi Iracema , Wormald Andrew , Galvin Miriam 
Published: March 2024

BackgroundThe social and economic challenges of the COVID-19 pandemic greatly impacted people's physical and mental health. The majority of care for individuals with brain health challenges, including dementia and mental illness, is provided by informal family caregivers. The “Coping with Loneliness, Isolation and COVID-19” (CLIC) Global Caregiver Survey 2020 received responses from over 5,000 caregivers across 50 countries of people living with enduring brain and/or physical health conditions.AimThis study examined English-speaking caregivers of people with brain health challenges (dementia and mental health conditions) descriptions of changes and interruptions in their ability to provide care in the context of the COVID-19 pandemic.Materials and methodsQuantitative and qualitative data were collected as part of the large-scale CLIC Global Caregiver Survey. Data from over 900 English language respondents were analyzed using descriptive statistics and thematic content analysis. A multidisciplinary team of clinicians and health policy practitioners participated in team-based qualitative analyses.ResultsThe majority of respondents were from the United States (71% USA), female (83%) and care providers to people living with dementia (81%). Respondents reported concerns about their loved one's physical and mental health, the limited access to other caregiving sources and the limited opportunities to maintain personal wellbeing. Practical, social, psychological and emotional impacts affected their ability to offer care. There was clear evidence that the disruption to health and social care services—institutions, day care and home services impacted the ability to offer care.DiscussionThe pandemic may be seen as a catastrophic “event” that negatively impacted lives and livelihoods. A number of the social determinants of health were negatively impacted for the caregivers surveyed during this prolonged period. Caring for caregivers and supportive health and social care interventions are required to maintain the wellbeing of this informal workforce. This study represents the largest, cross-country survey on the impact of the COVID-19 pandemic on caregivers of people with brain health challenges to date; serving as an important resource for support agencies and to inform policy.
NGHIÊN CỨU ĐỘC TÍNH CẤP VÀ TÁC ĐỘNG GIẢM ĐAU CỦA CAO CHIẾT CỎ GÀ (CYNODON DACTYLON (L.) PERS. POACEAE)
Authors: Hà Võ Thị Thu , Hiền Nguyễn Thị Thu 
Published: March 2024

Tại Việt Nam, Cỏ gà (Cynodon dactylon (L.) Pers.) được sử dụng để chữa lỵ, chống viêm, nhức đầu trong các bài thuốc cổ truyền. Tuy nhiên, những nghiên cứu về tác dụng dược lý của dược liệu này vẫn còn hạn chế. Nghiên cứu được thực hiện nhằm khảo sát độc tính cấp và tác dụng giảm đau ngoại biên của cao chiết Cỏ gà trên chuột nhắt trắng. Cỏ gà được thu hái tại Bình Định. Dùng phương pháp chiết nóng với nước cất để thu được cao đặc. Độc tính cấp đường uống được thực hiện theo hướng dẫn của Bộ Y tế năm 2015. Tác động giảm đau ngoại biên được tiến hành trên mô hình gây đau quặn bằng acid acetic. Cao chiết Cỏ gà liều 5000 mg/kg không làm tử vong hay thay đổi hành vi chuột thử nghiệm. Ở liều 250 mg/kg và 500 mg/kg, cao chiết làm giảm có ý nghĩa thống kê về số lần đau và thời gian đau so với lô chứng. Kết quả nghiên cứu cho thấy cao chiết Cỏ gà không thể hiện độc tính cấp trên chuột và được xếp vào nhóm chất hầu như không độc. Cao chiết Cỏ gà thể hiện tác động giảm đau ngoại biên ở liều 250 và 500 mg/kg trên mô hình thực nghiệm.