bluuebunny/crossref_metadata_2025_split huggingface dataset:
Copper‐Catalyzed α‐Indolmethylation of 2‐Pyridylacetates with 3‐Indoleacetic Acids via Alkylideneindolenine Intermediates
Authors: Chen Chen , Chen Yongjun , Kong Weiya , Pang Jianxin , Tang Xiaodong 
Published: April 2024

AbstractThis study reports the copper‐catalyzed α‐indolmethylation of 2‐pyridylacetates with 3‐indoleacetic acids. This reaction offers an approach to generating alkylideneindolenine electrophiles via the oxidative decarboxylation of 3‐indoleacetic acids. The developed reaction system demonstrates good versatility, extending beyond the indolmethylation of 2‐pyridylacetates to include activated esters and nitroalkanes. Moreover, a biological evaluation revealed that several products exhibited antiproliferative activity against different cancer cell lines.
Cobalt‐Catalyzed Annulation of Benzimidates or NH‐Benzaldimines with Ynamides: Synthesis of 1‐Alkoxy‐ and 1‐Alkyl‐3‐Aminoisoquinolines
Authors: Sanaa Hamdi , Mimoun Liliane , Retailleau Pascal , Anselmi Elsa , Nicolas Cyril , Gillaizeau Isabelle 
Published: April 2024

AbstractInexpensive cobalt‐catalyzed, pivalic acid‐assisted oxidative C−H functionalization of benzimidates or NH‐benzaldimines with ynamides is presented, providing an access to 3‐aminoisoquinoline derivatives. The procedure is compatible with various substrates featuring alkyl, alkoxy, acyl or halogen as substituents, heteroaryl structures, and diverse ynamides. The reaction has been scaled up, with subsequent transformation of the yielded products. Control experiments and mechanistic investigations corroborate the regioselectivity of this conversion, positioning the amine group proximal to the nitrogen atom in isoquinolines.
Organocatalyzed, Three‐Component Construction of Cyanopyrazoles Using Diazoacetonitrile
Authors: Dhami Anamika , Kumar Anuj , Nasreen Hisana Kalathingal , Mohanan Kishor 
Published: April 2024

AbstractAn organocatalyzed three‐component protocol using diazoacetonitrile to access a wide range of cyanopyrazole derivatives is reported here. This strategy, which proceeds through a piperidine‐catalyzed Knoevenagel condensation/formal [3+2] cycloaddition/dehydrocyanation sequence, provides an efficient route to construct dicyanopyrazoles from aldehydes, malononitrile, and diazoacetonitrile regioselectively. Interestingly, by engaging cyanoacetate and cyanoacetamide in this protocol, we could achieve cyanopyrazole esters and carboxamides.
HnRNPA2B1 ISGylation Regulates m6A‐Tagged mRNA Selective Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development
Authors: Jin Ting , Yang Liping , Chang Chao , Luo Haojun , Wang Rui , Gan Yubi , Sun Yan , Guo Yuetong , Tang Rui , Chen Shanchun , Meng Die , Dai Peijin , Liu Manran 
Published: April 2024

AbstractRegulating nuclear export precisely is essential for maintaining mRNA homeostasis and impacts tumor progression. However, the mechanisms governing nuclear mRNA export remain poorly elucidated. Herein, it is revealed that the enhanced hypoxic long no‐ncoding RNA (lncRNA prostate cancer associated transcript 6 (PCAT6) in breast cancer (BC) promotes the nuclear export of m6A‐modified mRNAs, bolstering breast cancer stem cells (BCSCs) stemness and doxorubicin resistance. Clinically, hypoxic PCAT6 correlates with malignant BC features and poor prognosis. Mechanically, PCAT6 functions as a scaffold between interferon‐stimulated gene 15 (ISG15) and heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1), leading to ISGylation of hnRNPA2B1, thus protecting hnRNPA2B1 from ubiquitination‐mediated proteasomal degradation. Interestingly, as an m6A reader, hnRNPA2B1 selectively mediates m6A‐tagged mRNAs nuclear export via the Aly/REF export factor (ALYREF)/ nuclear RNA export factor 1 (NXF1) complex, which promotes stemness‐related genes expression. HnRNPA2B1 knockdown or mRNA export inhibition can result in the retention of nuclear m6A‐tagged mRNA associated with stemness maintenance, which suppresses BCSCs self‐renewal and effectively improves the efficacy of doxorubicin therapy. These findings demonstrate the pivotal role of m6A‐modified mRNA nuclear export in BC progression, highlighting that the inhibition of m6A‐tagged mRNA and its nuclear export is a potential therapeutic strategy for the amelioration of cancer chemotherapy.
On‐Surface Synthesis of Organolanthanide Sandwich Complexes
Authors: Mathialagan Shanmugasibi K. , Parreiras Sofia O. , Tenorio Maria , Černa Lenka , Moreno Daniel , Muñiz‐Cano Beatriz , Navío Cristina , Valvidares Manuel , Valbuena Miguel A. , Urgel José I. , Gargiani Pierluigi , Miranda Rodolfo , Camarero Julio , Martínez José I. , Gallego José M. , Écija David 
Published: April 2024

AbstractThe synthesis of lanthanide‐based organometallic sandwich compounds is very appealing regarding their potential for single‐molecule magnetism. Here, it is exploited by on‐surface synthesis to design unprecedented lanthanide‐directed organometallic sandwich complexes on Au(111). The reported compounds consist of Dy or Er atoms sandwiched between partially deprotonated hexahydroxybenzene molecules, thus introducing a distinct family of homoleptic organometallic sandwiches based on six‐membered ring ligands. Their structural, electronic, and magnetic properties are investigated by scanning tunneling microscopy and spectroscopy, X‐ray absorption spectroscopy, X‐ray linear and circular magnetic dichroism, and X‐ray photoelectron spectroscopy, complemented by density functional theory‐based calculations. Both lanthanide complexes self‐assemble in close‐packed islands featuring a hexagonal lattice. It is unveiled that, despite exhibiting analogous self‐assembly, the erbium‐based species is magnetically isotropic, whereas the dysprosium‐based compound features an in‐plane magnetization.
Unravelling the Bi‐Functional Electrocatalytic Properties of {Mo72Fe30} Polyoxometalate Nanostructures for Overall Water Splitting Using Scanning Electrochemical Microscope and Electrochemical Gating Methods
Authors: Krishnamoorthy Karthikeyan , Pazhamalai Parthiban , Swaminathan Rajavarman , Mohan Vigneshwaran , Kim Sang‐Jae 
Published: April 2024

AbstractThis study reports the use of Keplerate‐type {Mo72Fe30} polyoxometalate (POMs) nanostructures as a bi‐functional‐electrocatalyst for HER and OER in an alkaline medium with a lower overpotential (135 mV for HER and 264 mV for OER), and excellent electrochemical stability. The bi‐functional catalytic properties of {Mo72Fe30} POM are studied using a scanning electrochemical microscope (SECM) via current mapping using substrate generation and tip collection mode. Furthermore, the bipolar nature of the {Mo72Fe30} POM nano‐electrocatalysts is studied using the electrochemical gating via simultaneous monitoring of the electrochemical (cell) and electrical ({Mo72Fe30} POM) signals. Next, a prototype water electrolyzer fabricated using {Mo72Fe30} POM electrocatalysts showed they can drive 10 mA cm−2 with a low cell voltage of 1.62 V in lab‐scale test conditions. Notably, the {Mo72Fe30} POM electrolyzers’ performance assessment based on recommended conditions for industrial aspects shows that they require a very low overpotential of 1.89 V to drive 500 mA cm−2, highlighting their promising candidature toward clean‐hydrogen production.
Mechanical Milling – Induced Microstructure Changes in Argyrodite LPSCl Solid‐State Electrolyte Critically Affect Electrochemical Stability
Authors: Wang Yixian , Hao Hongchang , Naik Kaustubh G. , Vishnugopi Bairav S. , Fincher Cole D. , Yan Qianqian , Raj Vikalp , Celio Hugo , Yang Guang , Fang Hong , Chiang Yet‐Ming , Perras Frédéric A. , Jena Puru , Watt John , Mukherjee Partha P. , Mitlin David 
Published: April 2024

AbstractMicrostructure of argyrodite solid‐state electrolyte (SSE) critically affects lithium metal electrodeposition/dissolution. While the stability of unmodified SSE is mediocre, once optimized state‐of‐the‐art electrochemical performance is achieved (symmetric cells, full cells with NMC811) without secondary interlayers or functionalized current collectors. Planetary mechanical milling in wet media (m‐xylene) is employed to alter commercial Li6PS5Cl (LPSCl) powder. Quantitative stereology demonstrates how milling progressively refines grain and pore size/distribution in the SSE compact, increases its density, and geometrically smoothens the SSE‐Li interface. Mechanical indentation demonstrates that these changes lead to reduced site‐to‐site variation in the compact's hardness. Milled microstructures promote uniform early‐stage electrodeposition on foil collectors and stabilize solid electrolyte interphase (SEI) reactivity. Analysis of half‐cells with bilayer electrolytes demonstrates the importance of microstructure directly contacting current collector, with interface roughness due to pore and grain size distribution being key. For the first time, short‐circuiting Li metal dendrite is directly identified, employing 1.5 mm diameter “mini” symmetrical cell and cryogenic focused ion beam (cryo‐FIB) electron microscopy. The branching sheet‐like dendrite traverses intergranularly, filling the interparticle voids and forming an SEI around it. Mesoscale modeling reveals the relationship between Li‐SSE interface morphology and the onset of electrochemical instability, based on underlying reaction current distribution.
Constructing Robust LiF‐Enriched Interfaces in High‐Voltage Solid‐State Lithium Batteries Utilizing Tailored Oriented Ceramic Fiber Electrolytes
Authors: Mu Yongbiao , Chu Youqi , Shi Yutao , Huang Chaozhu , Yang Lin , Zhang Qing , Li Chi , Feng Yitian , Zhou Yuke , Han Meisheng , Zhao Tianshou , Zeng Lin 
Published: April 2024

AbstractThe pursuit of high‐performance energy storage devices has fueled significant advancements in the all‐solid‐state lithium batteries (ASSLBs). One of the strategies to enhance the performance of ASSLBs, especially concerning high‐voltage cathodes, is optimizing the structure of composite polymer electrolytes (CPEs). This study fabricates a high‐oriented framework of Li6.4La3Zr2Al0.2O12 (o‐LLZO) ceramic nanofibers, meticulously addressing challenges in both the Li metal anode and the high‐voltage LiNi0.8Co0.1Mn0.1O2 (NCM811) cathode. The as‐constructed electrolyte features a highly efficient Li+ transport and robust mechanical network, enhancing both electron and ion transport, ensuring uniform current density distribution, and stress distribution, and effectively suppressing Li dendrite growth. Remarkably, the Li symmetric cells exhibit outstanding long‐term lifespan of 9800 h at 0.1 mA cm−2 and operate effectively over 800 h even at 1.0 mA cm−2 under 30 °C. The CPEs design results from the formation of a gradient LiF‐riched SEI and CEI film at the Li/electrolyte/NCM811 dual interfaces, enhancing ion conduction and maintaining electrode integrity. The coin‐cells and pouch cells demonstrate prolonged cycling stability and superior capacity retention. This study sets a notable precedent in advancing high‐energy ASSLBs.
Nanofibrous Covalent Organic Frameworks Based Hierarchical Porous Separators for Fast‐Charging and Thermally Stable Lithium Metal Batteries
Authors: Wang Kexiang , Duan Ju , Chen Xin , Wang Jianan , Li Jiaqiang , Jiang Lexin , Yan Wei , Lyu Wei , Liao Yaozu 
Published: April 2024

AbstractEngineering multifunctional smart separators are important for the ongoing pursuit of fast‐charging and safe batteries. Herein, a novel nanofibrous covalent organic framework (COF) based separator with well‐designed hierarchical porous channels is fabricated to effectively regulate mass transport for fast‐charging and thermally stable lithium metal batteries (LMBs). Such a hierarchical porous separator consists of electrospun polyacrylonitrile nanofibers with macroporous channels (average diameter of 323 nm) and mesoporous channels (≈7 nm) created between amide‐group‐bonded COF nanoparticles with intrinsic 1.6 nm lithiophilic microporous channels (PAN/AM‐COF). Computational fluid dynamics and density functional theory calculations demonstrate that PAN/AM‐COF can simultaneously facilitate high‐speed and selective transport of Li+, as well as homogeneous deposition of Li, achieving high conductivity (3.33 mS cm−1) and high Li+ transference number (0.79). As a result, Li || LFP full cell with PAN/AM‐COF displays superior cycling stability at 10 C with an acceptable capacity attenuation (0.037% per cycle) over 1000 cycles. Moreover, when operating under an extreme temperature of 100 °C, the Li || LFP full cell with PAN/AM‐COF can still operate stably for 300 cycles at 30 C, highlighting its potential processing scalability for ultrafast‐charging energy storage systems. This study gives insights into designing functional separators for fast‐charging LMBs.
Estimating soil organic carbon sequestration potential in the Chinese Mollisols region
Authors: Li Hui , Qian Rongfang , Pei Jiubo , Li Shuangyi , Wang Jingkuan 
Published: April 2024

AbstractMollisols region of China is a ballast stone of Chinese food security. In this study, 484 soil organic carbon (SOC) data points from the documented soil surface (0–20 cm) samples in the typical Chinese Mollisols region were selected. The regional soil fertility was divided into high, medium, and low levels based on the SOC content from the long‐term positioning fertilization stations in Shenyang, Harbin, and Hailun of Northeast China. Furthermore, the regional SOC balance point (SOCb) model was built driven by the factors of annual mean temperature, annual precipitation, annual effective accumulative temperature, the ratio of precipitation and temperature, soil clay content, and pH. Using geographic information systems (GIS) interpolation method, the regional mean SOCb and SOC sequestration potential (SOCsp) at the SOCb's status were simulated to be 40.10 g kg−1 and 10.71 kg m−2, respectively. Moreover, the SOC content increased (SOCc) and the SOC sequestration capacity increased of medium‐ or low‐fertility soil were evaluated by GIS subtraction. Consequently, the means of SOCc in medium‐ and low‐fertility soils could be 16.88 g kg−1 and 26.79 g kg−1, respectively. Furthermore, the means of SOCsp in medium‐ and low‐fertility soils could be 4.30 kg m−2 and 7.43 kg m−2, respectively. The sensitivity analysis of this model showed that the high SOCb area was distributed in study region with low temperature, dry, high clay content, and low pH. The results provide an actual perspective on estimating regional SOCsp and soil fertility promotion target induced by the different soil fertility levels.
The marriage of perovskite nanocrystals with lanthanide‐doped upconversion nanoparticles for advanced optoelectronic applications
Authors: Zhang Wen , Zheng Wei , Huang Ping , Yang Dengfeng , Shao Zhiqing , Chen Xueyuan 
Published: April 2024

AbstractThe exceptional optoelectronic properties of lead halide perovskite nanocrystals (PeNCs) in the ultraviolet and visible spectral regions have positioned them as a promising class of semiconductor materials for diverse optoelectronic and photovoltaic applications. However, their limited response to near‐infrared (NIR) light due to the intrinsic bandgap (>1.5 eV) has hindered their applications in many advanced technologies. To circumvent this limitation, it is of fundamental significance to integrate PeNCs with lanthanide‐doped upconversion nanoparticles (UCNPs) that are capable of efficiently converting low‐energy NIR photons into high‐energy ultraviolet and visible photons. By leveraging the energy transfer from UCNPs to PeNCs, this synergistic combination can not only expand the NIR responsivity range of PeNCs but also introduce novel emission profiles to upconversion luminescence with multi‐dimensional tunability (e.g., wavelength, lifetime, and polarization) under low‐to‐medium power NIR irradiation, which breaks through the inherent restrictions of individual PeNCs and UCNPs and thereby opens up new opportunities for materials and device engineering. In this review, we focus on the latest advancements in the development of PeNCs‐UCNPs nanocomposites, with an emphasis on the controlled synthesis and optical properties design for advanced optoelectronic applications such as full‐spectrum solar cells, NIR photodetectors, and multilevel anticounterfeiting. Some future efforts and prospects toward this active research field are also envisioned.
Seasonal variability in body mass index, waist circumference, and skinfolds in Norwegian children
Authors: Moen Oda Klavestad , Júlíusson Pétur Benedikt , Roelants Mathieu , Spielau Ulrike 
Published: April 2024

AbstractObjectivesStudies have shown that children develop a higher body weight during summer months. This has been demonstrated repeatedly using the body mass index (BMI), but the effect of season on other weight‐related anthropometric measurements is still unclear.MethodsMeasurements of height, weight, waist circumference (WC), triceps, and subscapular skinfolds (TSF and SSF), collected from September till May in a cross‐sectional sample of 4–16‐year‐old children and adolescents (n = 4525) from the Bergen Growth Study 1 (BGS1). Differences in z‐score by season were tested with linear models adjusted for age group and separately for sex. Overall differences were tested with a one‐way between‐group analysis of variance.ResultsThe girls had higher BMIz (+0.12, p = .03) and WCz (+0.18, p = .002) in fall compared with spring. TSFz (−0.19, p < .001) and SSFz (−0.18, p < .001) were lower in winter in girls, and in boys both in fall (TSFz −0.10, p = .046; SSFz – 0.16, p < .001), and winter (TSFz −0.15, p = .004; SSFz −0.14, p = .003), when compared with spring.ConclusionsSeasonal variation was detected for all anthropometric measures, but differences in the direction of the effect between measures of global (BMI), central (WC) or subcutaneous (SF) adiposity suggest a more complex mechanism that needs further exploration.
Immunological and hematological findings as major features in a patient with a new germline pathogenic CBL variant
Authors: Stellacci Emilia , Carter Jennefer N. , Pannone Luca , Stevenson David , Moslehi Dorsa , Venanzi Serenella ,   Undiagnosed Diseases Network, Bernstein Jonathan A. , Tartaglia Marco , Martinelli Simone 
Published: April 2024

AbstractCasitas B‐lineage lymphoma (CBL) encodes an adaptor protein with E3‐ligase activity negatively controlling intracellular signaling downstream of receptor tyrosine kinases. Somatic CBL mutations play a driver role in a variety of cancers, particularly myeloid malignancies, whereas germline defects in the same gene underlie a RASopathy having clinical overlap with Noonan syndrome (NS) and predisposing to juvenile myelomonocytic leukemia and vasculitis. Other features of the disorder include cardiac defects, postnatal growth delay, cryptorchidism, facial dysmorphisms, and predisposition to develop autoimmune disorders. Here we report a novel CBL variant (c.1202G>T; p.Cys401Phe) occurring de novo in a subject with café‐au‐lait macules, feeding difficulties, mild dysmorphic features, psychomotor delay, autism spectrum disorder, thrombocytopenia, hepatosplenomegaly, and recurrent hypertransaminasemia. The identified variant affects an evolutionarily conserved residue located in the RING finger domain, a known mutational hot spot of both germline and somatic mutations. Functional studies documented enhanced EGF‐induced ERK phosphorylation in transiently transfected COS1 cells. The present findings further support the association of pathogenic CBL variants with immunological and hematological manifestations in the context of a presentation with only minor findings reminiscent of NS or a clinically related RASopathy.
Chronic stress, social support, and symptoms at midlife. Is there a buffering effect?
Authors: Rulu Peteneinuo , Bertone‐Johnson Elizabeth R. , Kamilar Jason , Dhall Meenal , Sievert Lynnette Leidy 
Published: April 2024

AbstractObjectivesThis study was designed to examine associations among measures of stress, social support, and symptoms at midlife. Specifically, the study examined whether support buffered against the negative effects of stress on severity of symptoms grouped via factor analyses into emotional instability, vaso‐somatic symptoms, mood disturbances, and aches and pains.MethodsWe used cross‐sectional data from n = 119 women aged 40–55 in Nagaland, India. Midlife symptoms were measured with the help of questionnaires, and factor analysis was used to identify latent factors. Stress and social support were measured by Perceived Stress Scale and Multidimensional Scale of Perceived Social Support, respectively. Chronic stress was measured by fingernail cortisol.ResultsAfter adjusting for menopausal status, tobacco use, body mass index, and socioeconomic status, cortisol level was positively associated with emotional instability (p < 0.01), vaso‐somatic symptom score (p < 0.05), and total symptoms at midlife (p < 0.05). Familial support was negatively associated with emotional instability (p < 0.05) and total symptoms at midlife (p < 0.05). However, no significant associations were observed with spousal or friend support. Although no significant interactions between stress, social support, and symptoms at midlife were observed, spousal support when stratified as high and low support using the means, perceived stress and vaso‐somatic symptoms indicated an interaction.ConclusionCortisol level and support from family were independently associated with symptoms at midlife. The study highlights the importance of family ties and support for navigating the stressors of everyday life among women in Nagaland.
Self‐Inclusion Complexation of Electron‐Accepting Guest into Electron‐Donating Cyclic Host by Photoexcitation
Authors: Wada Keisuke , Nagata Yuuya , Cui Luxia , Ono Toshikazu , Akine Shigehisa , Ohtani Shunsuke , Kato Kenichi , Fa Shixin , Ogoshi Tomoki 
Published: April 2024

AbstractSelf‐inclusion complexes consisting of host‐guest conjugates are one of the unique supramolecular structures because they form in‐state and out‐state depending on the external stimuli. Despite many reports of the stimuli‐responsive self‐inclusion complex formation, study of the structural relaxation from out‐state to in‐state by photoexcitation has been unexplored. Herein, we report that an electron‐donating host and an electron‐accepting guest conjugate exhibits the structural relaxation from out‐state to in‐state by photoexcitation. Formation of the in‐state in the excited state resulted in exciplex emission along with the locally excited emission from the out‐state. Moreover, this structural relaxation by photoexcitation was suppressed not only by temperature, but also by the presence of guest molecules, resulting in changes in the ratio of the dual emission intensities.