bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term efficacy of a 2-year MRI treat-to-target strategy on disease activity and radiographic progression in patients with rheumatoid arthritis in clinical remission: 5-year follow-up of the IMAGINE-RA randomised trial
Authors: Møller-Bisgaard Signe , Hørslev-Petersen Kim , Ørnbjerg Lykke Midtbøll , Ejbjerg Bo , Hetland Merete Lund , Møller Jakob Møllenbach , Nielsen Sabrina Mai , Glinatsi Daniel , Boesen Mikael , Stengaard-Pedersen Kristian , Madsen Ole Rintek , Jensen Bente , Villadsen Jan Alexander , Hauge Ellen Margrethe , Hendricks Oliver , Lindegaard Hanne , Krogh Niels Steen , Jurik Anne Grethe , Thomsen Henrik , Christensen Robin , Østergaard Mikkel 
Published: March 2024

ObjectiveTo investigate whether a 2-year MRI treat-to-target strategy targeting the absence of osteitis combined with clinical remission, compared with a conventional treat-to-target strategy targeting clinical remission only (IMAGINE-rheumatoid arthritis (RA) trial) improves clinical and radiographic outcomes over 5 years in patients with RA in clinical remission.MethodsIMAGINE-more was an observational extension study of the original 2-year IMAGINE-RA randomised trial (NCT01656278). Clinical examinations and radiographs (hands and feet) were obtained yearly. Prespecified coprimary outcomes at year 5 were Disease Activity Score in 28 joints C reactive protein (DAS28-CRP) remission rate (DAS28-CRP<2.6) and no radiographic progression (van der Heijde-modified Sharp score (vdHSS) ≤0) from baseline. Secondary outcomes included 5-year changes in radiographic, MRI and clinical measures of disease activity and physical function.ResultsIn total 131 patients, 86 women (67%), mean age 61.2, disease duration 9.5 years, median baseline DAS28-CRP 1.9 (IQR 1.6–2.2) and vdHSS 16.0 (IQR 7.0–36.0) were included in the study; 59 (59%) patients from the original MRI treat-to-target group and 72 (72%) from the conventional group. At year 5, 47 patients (80%) in the MRI treat-to-target group vs 54 patients (75%) in the conventional treat-to-target group were in DAS28-CRP remission (OR 2.00 (95% CI 0.76 to 5.28); p=0.16) while 14 patients (24%) vs 19 patients (26%) had no radiographic progression (OR 0.70, (95% CI 0.28 to 1.71); p=0.43).ConclusionA 2-year combined MRI and clinical treat-to-target strategy, compared with a conventional clinical treat-to-target strategy alone, had no effect on the long-term probability of achieving DAS28-CRP remission and of avoiding radiographic progression.
Tracing the lead source of maiolica: a pilot isotopic study on artefacts from the area of Florence, Italy (fifteenth–nineteenth century)
Authors: Paghi Diletta , Manca Rosarosa , Casalini Martina , Chiarantini Laura , Bragagni Alessandro , Tommasini Simone , Benvenuti Marco 
Published: March 2024

AbstractThe manufacturing of Italian maiolica (tin-glazed pottery) was extremely appreciated during the Middle Ages and Renaissance, leading to the production and collection of a rich cultural heritage. This pilot study aims to characterize the production technique and the origin of the lead used as a flux in a set of samples of maiolica glazes made in the area of Florence over a wide time span, ranging from the fifteenth to the nineteenth century. In particular, this is the first study that applies provenance analysis, using lead isotopes, to tin-glazed artefacts made in the site of Montelupo Fiorentino and by the Ginori manufactory in Doccia (Florence, Italy), both important production centres of ceramics in Italy. The samples were first analysed by scanning electron microscopy to characterize their layer structure and chemical composition. Lead isotope analysis was then performed by thermal ionization mass spectrometry and showed that the samples tend to be distributed into distinct groups according to their period of production. Moreover, the comparison with the lead isotope composition of the deposits of the European and circum-Mediterranean area from which lead was historically extracted showed that the isotopic composition of the samples differs from that of the Italian deposits, suggesting that lead was imported from abroad. The isotopic composition of all the investigated maiolica glazes is compatible with German ore deposits, in agreement with what is reported by the historical sources relating to the lead supply areas.
Level of self-efficacy among skill-based allied health students in the University of Santo Tomas-Enriched Virtual Mode of learning: A cross-sectional study
Authors: Manlapaz Donald G. , Versales Cristine Rose S. , Pazcoguin John Micko A. , Ching Justin Jeremiah A. , Bartolome Marcela Joyce P. , Da Silva Samantha Lavin , Edquila Kertlouie Gabriel Z. , Francheska Fulo Lara , Benezet J. Male Yvonne Geisel , Patricia Y. Peña Joey , Miguel C. Pineda Ramon 
Published: March 2024

Background: Self-efficacy expresses a learner’s perception of how well they can do in the online academic setting. Although students’ academic successes can be measured by online learning self-efficacy, there is a scarcity of evidence targeted toward allied health students.Objective: The primary aim of this study is to determine the level of online self-efficacy among students from skill-based allied health programs. The secondary aim is to correlate online self-efficacy with age, sex, year level, and program of the students.Methods: This cross-sectional analytic study utilized the Online Learning Self-Efficacy Scale (OLSE) to determine students’ level of self-efficacy via a survey conducted with students who underwent the Enriched Virtual Mode of learning. Descriptive statistics was used to characterize the study participants, describe the level of self-efficacy, and compare the subscales of OLSE. Inferential statistics using Spearman’s rho was performed to determine the correlation.Results: A total of 117 respondents with a mean age ± SD of 20.59 ± 0.11 years old, predominantly female (71%) were included in the study. The students from allied health programs had an online self-efficacy overall mean score of 3.83 ([Formula: see text]; range 2.64–5.00) with the use of technology subscales weighted the highest mean score (4.24). Females have a higher average OLSE score ([Formula: see text], [Formula: see text]) compared to males. Significant correlation was found between OLSE scores to sex ([Formula: see text], [Formula: see text]) and year level ([Formula: see text], [Formula: see text]) while nonsignificant correlation was found between OLSE scores to the program ([Formula: see text], [Formula: see text]) and age ([Formula: see text], [Formula: see text]).Conclusion: Students of allied health programs generally have a very good level of online self-efficacy. This study assists educators in developing proactive strategies and approaches to promote students’ self-confidence across all domains and encourage them to adopt a dynamic remote learning-based approach. Educational institutions should use this opportunity to assess how well they have implemented remote learning to ensure educational continuity, especially in times of crisis.
FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma
Authors: Huang Jiao , Tsang Wai Ying , Fang Xiao-Na , Zhang Yu , Luo Jie , Gong Lan-Qi , Zhang Bai-Feng , Wong Ching Ngar , Li Zhi-Hong , Liu Bei-Lei , Huang Jin-Lin , Yang Yu-Ma , Liu Shan , Ban Liu-Xian , Chan Yiu Hong , Guan Xin-Yuan 
Published: March 2024

Abstract

Immune checkpoint inhibitors (ICI) transformed the treatment landscape of hepatocellular carcinoma (HCC). Unfortunately, patients with attenuated MHC-I expression remain refractory to ICIs, and druggable targets for upregulating MHC-I are limited. Here, we found that genetic or pharmacologic inhibition of fatty acid synthase (FASN) increased MHC-I levels in HCC cells, promoting antigen presentation and stimulating antigen-specific CD8+ T-cell cytotoxicity. Mechanistically, FASN inhibition reduced palmitoylation of MHC-I that led to its lysosomal degradation. The palmitoyltransferase DHHC3 directly bound MHC-I and negatively regulated MHC-I protein levels. In an orthotopic HCC mouse model, Fasn deficiency enhanced MHC-I levels and promoted cancer cell killing by tumor-infiltrating CD8+ T cells. Moreover, the combination of two different FASN inhibitors, orlistat and TVB-2640, with anti–PD-L1 antibody robustly suppressed tumor growth in vivo. Multiplex IHC of human HCC samples and bioinformatic analysis of The Cancer Genome Atlas data further illustrated that lower expression of FASN was correlated with a higher percentage of cytotoxic CD8+ T cells. The identification of FASN as a negative regulator of MHC-I provides the rationale for combining FASN inhibitors and immunotherapy for treating HCC.

Significance:
Inhibition of FASN increases MHC-I protein levels by suppressing its palmitoylation and lysosomal degradation, which stimulates immune activity against hepatocellular carcinoma and enhances the efficacy of immune checkpoint inhibition.
Brain sodium MRI-derived priors support the estimation of epileptogenic zones using personalized model-based methods in epilepsy
Authors: Azilinon Mikhael , Wang Huifang E. , Makhalova Julia , Zaaraoui Wafaa , Ranjeva Jean-Philippe , Bartolomei Fabrice , Guye Maxime , Jirsa Viktor 
Published: March 2024

Abstract
Patients presenting with drug-resistant epilepsy are eligible for surgery aiming to remove the regions involved in the production of seizure activities, the so-called epileptogenic zone network (EZN). Thus the accurate estimation of the EZN is crucial. Data-driven, personalized virtual brain models derived from patient-specific anatomical and functional data are used in Virtual Epileptic Patient (VEP) to estimate the EZN via optimization methods from Bayesian inference. The Bayesian inference approach used in previous VEP integrates priors, based on the features of stereotactic-electroencephalography (SEEG) seizures’ recordings. Here, we propose new priors, based on quantitative 23Na-MRI. The 23Na-MRI data were acquired at 7T and provided several features characterizing the sodium signal decay. The hypothesis is that the sodium features are biomarkers of neuronal excitability related to the EZN and will add additional information to VEP estimation. In this paper, we first proposed the mapping from 23Na-MRI features to predict the EZN via a machine learning approach. Then, we exploited these predictions as priors in the VEP pipeline. The statistical results demonstrated that compared with the results from current VEP, the result from VEP based on 23Na-MRI prior has better balanced accuracy, and the similar weighted harmonic mean of the precision and recall.
Forbidden Books and Royal Horoscopes: the Practice and Censorship of Astrology in Early Modern Portugal
Authors: Ribeiro Luís Campos , Malta Romeiras Francisco 
Published: March 2024

Abstract
In sixteenth-century Lisbon, Aires Vaz and Manuel Rodrigues were summoned to the Inquisition on account of their astrological practices. Records of the trial of Vaz and Rodrigues provide valuable information regarding the training and practice of an astrologer in sixteenth-century Portugal. Prior to this study, however, our knowledge on these matters was scarce and mostly indirect. In this article, we argue that the study of these trial records is crucial to understanding both the practice and the regulation of astrology. Studies on the censorship of astrology usually emphasize the importance of the Roman Index, the Tridentine Rules, and the papal bulls against astrology. By looking at these two trials, this article sheds new light on the application of the Roman rules and allows us to trace the general profile of an astrologer in early modern Portugal.
The Anatomy of Galileo’s Anagram
Authors: Reeves Eileen 
Published: March 2024

Abstract
This essay offers a new reading of Galileo’s most celebrated anagram, incorporating both the prehistory of his late-1610 disclosure concerning the moon-like phases of Venus, and the awkward “leftover letters,” o and y, of the eventual cypher. It argues for a sustained analogy between components of the optical instrument, musical instruments, and particular anatomical structures described by Galen and elaborated by early modern anatomists in Padua. It proposes, finally, the cypher as a calculated response to the Neapolitan magus and playwright Giambattista della Porta’s challenge to Galileo’s claims about the telescope itself.
CAR T-cell Therapy for Diffuse Large B-cell Lymphoma in Canada: A Cost-Utility Analysis
Authors: Masucci Lisa , Tian Feng , Tully Stephen , Feng Zeny , McFarlane Tom , Chan Kelvin K. W. , Wong William W. L. 
Published: March 2024

Background Chimeric antigen receptor (CAR) T-cell therapy is a novel cell therapy for treating non-Hodgkin lymphoma. The development of CAR T-cell therapy has transformed oncology treatment by offering a potential cure. However, due to the high cost of these therapies, and the large number of eligible patients, decision makers are faced with difficult funding decisions. Our objective was to assess the cost-effectiveness of tisagenlecleucel for adults with relapsed/refractory diffuse large B-cell lymphoma in Canada using updated survival data from the recent JULIET trial. Methods We developed an individual-simulated discrete event simulation model to assess the costs and quality-adjusted life-years (QALY) of tisagenlecleucel compared with salvage chemotherapy. Survival estimates were obtained from a published clinical trial and retrospective analysis. If patients remained progression free for 5 y, they were assumed to be in long-term remission. Costing and utility data were obtained from reports and published sources. A Canadian health care payer perspective was used, and outcomes were modeled over a lifetime horizon. Costs and outcomes were discounted at 1.5% annually, with costs reported in 2021 Canadian dollars. A probabilistic analysis was used, and model parameters were varied in 1-way sensitivity analyses and scenario analyses. Results After we incorporated the latest clinical evidence, tisagenlecleucel led to an additional cost of $503,417 and additional effectiveness of 2.48 QALYs, with an incremental cost-effectiveness ratio of $202,991 compared with salvage chemotherapy. At a willingness-to-pay threshold of $100,000/QALY, tisagenlecleucel had a 0% likelihood of being cost-effective. Conclusions At the current drug price, tisagenlecleucel was not found to be a cost-effective option. These results heavily depend on assumptions regarding long-term survival and the price of CAR T. Real-world evidence is needed to reduce uncertainty. Highlights For patients with diffuse large B-cell lymphoma who failed 2 or more lines of systemic therapy, CAR T was not found to be a cost-effective treatment option at a willingness-to-pay threshold of $100,000. These results heavily depend on the expected long-term survival. The uncertainty in the model may be improved using real-world evidence reported in the future.
Non-invasive assessment of response to transcatheter arterial chemoembolization for hepatocellular carcinoma with the deep neural networks-based radiomics nomogram
Authors: Liu Yushuang , Liu Zilin , Li Xinhua , Zhou Weiwen , Lin Lifu , Chen Xiaodong 
Published: March 2024

Background Transcatheter arterial chemoembolization (TACE) is a mainstay treatment for intermediate and advanced hepatocellular carcinoma (HCC), with the potential to enhance patient survival. Preoperative prediction of postoperative response to TACE in patients with HCC is crucial. Purpose To develop a deep neural network (DNN)-based nomogram for the non-invasive and precise prediction of TACE response in patients with HCC. Material and Methods We retrospectively collected clinical and imaging data from 110 patients with HCC who underwent TACE surgery. Radiomics features were extracted from specific imaging methods. We employed conventional machine-learning algorithms and a DNN-based model to construct predictive probabilities (RScore). Logistic regression helped identify independent clinical risk factors, which were integrated with RScore to create a nomogram. We evaluated diagnostic performance using various metrics. Results Among the radiomics models, the DNN_LASSO-based one demonstrated the highest predictive accuracy (area under the curve [AUC] = 0.847, sensitivity = 0.892, specificity = 0.791). Peritumoral enhancement and alkaline phosphatase were identified as independent risk factors. Combining RScore with these clinical factors, a DNN-based nomogram exhibited superior predictive performance (AUC = 0.871, sensitivity = 0.844, specificity = 0.873). Conclusion In this study, we successfully developed a deep learning-based nomogram that can noninvasively and accurately predict TACE response in patients with HCC, offering significant potential for improving the clinical management of HCC.
Spectrum and antibiotic resistance in community- and hospital-acquired urinary tract infections among adults: Experience from a large tertiary care center in a developing country
Authors: Herbawi Aya , Abu Taha Adham , Aiesh Banan M. , Sabateen Ali , Zyoud Sa’ed H. 
Published: March 2024

Background: It is important to note that the causative agents and patterns of antibiotic resistance vary between urinary tract infections (UTIs) acquired in the community and those acquired in a hospital setting. Therefore, the aim of this study was to compare the types of organisms and patterns of antibiotic resistance in adult patients with community-acquired urinary tract infections (CA-UTIs) and hospital-acquired urinary tract infections (HA-UTIs). Methods: Retrospectively, we collected urine samples from patients at An-Najah National University Hospital who experienced nonrecurring urinary tract infections (UTIs) between January 2019 and December 2020. The data were subsequently analyzed using IBM-SPSS® 21.0 software to determine the distribution of microorganisms and evaluate the rates of antibiotic resistance. Results: A total of 798 nonrepetitive UTI patients were included in our study, in which more than half of the UTIs occurred in female patients (472; 59.1%), and most of the UTIs were of community origin (611; 76.6%). Both community-acquired urinary tract infections (CA-UTIs) and hospital-acquired urinary tract infections (HA-UTIs) were more common in female patients (45.6% and 13.5%, respectively). Escherichia coli was the most commonly isolated urinary pathogen in both the CA-UTIs and HA-UTIs. The five most common isolated urinary pathogens were E. coli, Klebsiella pneumoniae, Enterococcus faecalis, E. faecium, and Pseudomonas aeruginosa. Among the isolated bacteria, 28.2% were extended-spectrum beta-lactamase (ESBL)-producing bacteria, 4.1% were carbapenem-resistant Enterobacterales (CRE), and 6.5% were vancomycin-resistant Enterococci. The most commonly isolated urinary pathogens from HA-UTIs showed higher resistance rates against all the tested antibiotics except for E. faecium, which showed greater resistance to tetracycline (42.5%) and quinupristin/dalfopristin (17.5%) in CA-UTIs. Conclusions: There are similarities in the etiological profiles of CA-UTI and HA-UTI, but the resistance rates are high, and urine culture is essential for the correct treatment of individual cases, even in primary care.
Google and Jio: Tapping Growth Opportunities Through Strategic Alliance
Authors: Salwan Prashant , Pandey Shailesh , Attri Rekha 
Published: March 2024

Alliances are cooperative business relationships in which two or more entities collaborate to achieve a common objective while maintaining their individual independence. An example of such an alliance is the partnership between Google and Reliance Jio Infocom Ltd. This strategic alliance was formed to address the prevailing market challenges and capitalize on the growth opportunities in the Indian smartphone market. Within this case, we delve into the strategic objectives that motivated Google and Jio to embark on this alliance, explore the growth strategies employed by both partners and assess the advantages gained from this partnership. Readers of this case study will gain insights into the significance of value creation and learn how markets can be shaped through innovative value propositions. Additionally, readers will be equipped to apply the VRIO framework, enabling them to evaluate how each strategic partner benefits from the addition of resources and capabilities, as well as to comprehend the critical success factors inherent in strategic alliances.
Hypersensitivity reaction to Abiraterone, successful desensitization protocol in prostate cancer patient
Authors: González Díaz Sandra N. , Vidal Gutiérrez Oscar , Rodríguez Román José Carlos , López Henríquez Raquel A. , Macouzet Sánchez Carlos , de Lira Quezada Cindy E. , Acuña Ortega Natalhie 
Published: March 2024

Introduction In prostate cancer, androgens are key in the growth of both normal prostate and cancer cells. Abiraterone acetate inhibits CYP17, an important target in prostate cancer given its central role in the production of adrenal and tumor-derived androgens. Although abiraterone is generally well tolerated, common adverse effects such as hypertension, hypokalemia, and hepatotoxicity have been reported. Clinical case We present the case of an 83-year-old Mexican man with high-volume EC IV prostate cancer resistant to castration, orchiectomy, and bone, liver, and lung metastases. First-line treatment with the CHAARTED scheme was indicated, by patient decision refuse chemotherapy treatment. On the fourth day of starting treatment, he developed pruritic erythematous macular skin lesions and urticaria on the posterior chest that resolved spontaneously. A generalized erythematous and pruritic maculopapular rash appeared 12 days after starting abiraterone, for which she was referred to allergies. Management and results An oral provocation test was performed for two days, presenting localized macular lesions eight hours after the administration of abiraterone. An oral desensitization protocol was carried out for ten days in which no hypersensitivity reactions were observed, thus achieving the successful administration of abiraterone.