bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carcinoma of the cystic duct
Authors: Yamaguchi Koji , Nishihara Kazuyoshi , Tsuneyoshi Masazumi 
Published: February 2007

AbstractCarcinoma of the cystic duct is a rare neoplasm, and we herein report four cases of carcinoma of the cystic duct. The patients consisted of a 69 year old and 71 year old woman and a 61 year old and 93 year old man. They complained of either abdominal pain or abdominal mass. All the tumors were microscopically well‐differentiated adenocarcinoma, mostly limited to the wall, that showed no lymph node or distant metastasis. Three patients who had undergone resection were doing well 20 days, 67 months, and 125 months after the operation, respectively. These findings may suggest that not only the early development of symptoms caused by obstruction of the narrow lumen of the cystic duct, but also slow growth and late metastasis produce a favorable clinical course in patients with carcinoma of the cystic duct.
Second cancer in patients treated for testicular seminoma
Authors: Stein Moshe , Loberant Norman , Laviov Michaela , Rennert Gaddy , Lachter Jesse , Kuten Abraham 
Published: February 2007

AbstractThe exact risk of developing a second primary cancer following radiotherapy for testicular seminoma is not known. At the Northern Israel Oncology Center, between the years 1968‐1988, 75 patients with early stage (I,IIA) testicular seminoma were treated by orchiectomy followed by radiation therapy. The overall 10‐ and 20‐year survival probability was 95% and 90%, respectively. Eight patients (11%) developed nine second cancers, with a cumulative rate of one case per 1,000 years of follow‐up. The second primary cancers were: two bronchogenic carcinomas, one contralateral seminoma, one thymoma, one papillary carcinoma of the thyroid, one carcinoma of the stomach, one transitional cell carcinoma of the urinary bladder, one carcinoma of the colon, and one malignant melanoma. Three of these tumors developed within the irradiated field. Five of these eight patients are alive with no evidence of recurrent cancer. We conclude that patients treated for seminoma have an increased risk of developing a second cancer. There is a need for greater awareness of this possibility. The overall prognosis remains favorable.
A long term follow‐up of pectoralis osteomyocutaneous flaps
Authors: Shaha Ashok 
Published: February 2007

AbstractReconstruction of the arch of the mandible has always been a difficult problem. The problem of reconstruction is compounded by bony defect and also the loss of soft tissue after resection of tumors of the floor of the mouth. A variety of different methods have been utilized for immediate and delayed reconstruction of the arch of the mandible with limited success. There are various post‐operative complications and problems related to infection, soft tissue loss, and recurrence of the tumor. A free microvascular reconstruction is considered the best and the state of the art. However, it requires specialized training and expertise in microvascular surgery. Other methods have been successful, such as the pectoralis myocutaneous flap, pectoralis osteomyocutaneous flap. We have utilized the pectoralis osteomyocutaneous flap in six instances. Two of these patients have been followed for a long time, ranging from 7‐8 years and we have noticed certain changes in the soft tissue and the rib. We are reporting here the long term results of the two patients who are alive from 7‐8 years. The major finding in these patients was rib resorption and deteriorating cosmetic appearance and development of “Andy Gump” deformity.
Female urethral diverticula with clear cell adenocarcinoma
Authors: Wheeler John S. , Flanigan Robert C. , Hong Hi Young , Walloch Jami L. 
Published: February 2007

AbstractClear cell adenocarcinoma in a urethral diverticulum in the female is a very rare and unusual tumor. We recently treated two patients with this tumor. Their presentation, histologic evaluation, and management are reviewed in light of the limited experience in the literature.
Experience with desmoid tumor in a community teaching hospital
Authors: Welling Richard E. , Hermann Mark E. , Kasper Gregory C. 
Published: February 2007

AbstractDesmoid tumors are rare fibroblastic proliferations that occur primarily in the abdomen and extremities. They have an estimated incidence in the United States of two to four per million inhabitants per year. A recent case of desmoid tumor prompted us to review past medical records for previous cases with the same diagnosis. Since 1985, our institution has treated five patients with a total of eight desmoid tumors. Four patients (80%) were female with ages ranging from 24 to 32 years. The other patient was a 22‐year‐old male with a history of Gardner's syndrome and recurrent desmoid tumors. The majority of our patients were females in the fertile age group, substantiating the hormonal effects believed to play a role in the development of these lesions. In addition, it became obvious that more investigations must be done in appropriate treatment of desmoid tumors and the documentation of these tumors in registries would be of significant benefit.
Accuracy of the bronchoscopic DNA content analysis of non‐small‐cell lung carcinoma
Authors: Haneda Hitoshi , Miyamoto Hiroshi , Isobe Hiroshi , Abe Shosaku , Akita Hirotoshi , Ishikuro Akihiko , Kawakami Yoshikazu , Okayasu Kenji , Endo Takashi , Inoue Kazuaki 
Published: February 2007

AbstractTo assess the accuracy of the bronchoscopic DNA content analysis, samples of non‐small‐cell lung carcinomas (NSCLC) were investigated by means of flow cytometry. Samples were dissociated using the detergent Triton X‐100. In 58 NSCLC cases, 39 (67%) had DNA aneuploid tumors. We compared the DNA indices of bronchoscopic brushing samples with 21 corresponding surgical samples. In 16 (76%) cases, DNA ploidy of both bronchoscopic and surgical samples were in concordance. In 3 (14%) cases, both bronchoscopic and surgical sample showed DNA aneuploidy, but the number of the DNA aneuploid stem cell lines was different. The cause of these differences was ascribed to the intratumor DNA heterogeneity. In 2 (10%) cases, the bronchoscopic sample showed DNA diploidy, but the surgical sample showed DNA aneuploidy. In these cases, tumor cells obtained by bronchoscopic brushing were so few that the small DNA aneuploid peak was undetectable in the DNA histogram. But the tumor DNA ploidy was evaluated correctly in 90% of 21 cases using bronchoscopic samples. Consequently, despite some drawbacks, the DNA ploidy diagnosis using bronchoscopic samples in this relatively small study, was almost as reliable as surgical samples.
Primary pleural mesotheliomas in south India: A 25‐year study
Authors: Kini Usha , Shariff Shameem , Thomas John A. 
Published: February 2007

AbstractIn this report from South India, 15 patients with primary pleural mesothelioma have been diagnosed in the 25‐year period 1, April 1966 through 31, March 1991, representing 0.02% of 76,239 biopsies received. The patients were mainly male with a mean age of 46.5 years. All except two had lived in urban Bangalore. None had been exposed to asbestos. The presentation clinically was peculiar, being continuous pricking pain, breathlessness, and cough with sputum. Physical and roentgenogram examination showed massive pleural effusion with irregular pleural thickening. Thoracotomy findings showed a distinct sessile nodularity with many slit‐like spaces. Histologically, 14 were epithelial type mesotheliomas and 1 was a sarcomatous type. While the epithelial type neoplasms showed patchy squamoid differentiation, all showed mucin production. The CEA was always observed in areas of moderate differentiation. Spread occurred centrifugally to local structures on the same side as the lesion.
Use of an instrument‐holding clip for deeply recessed anastomoses of the rectum and esophagus
Authors: Didolkar Mukund S. , Cawley C. Michael 
Published: February 2007

AbstractPosterior layer closure of deeply located anastomoses including those performed in the course of low anterior rectal resection, total gastrectomy, and esophagogastrectomy, are often difficult. Usually five to six seromuscular or through‐and‐through posterior wall sutures are inserted sequentially and the loop or cut end of bowel is advanced over these parallel sutures. The sutures are then tied down. Entanglement of these sutures in a deep surgical field with limited access can lead to tears in the bowel wall. In addition, uneven and nonsequential tying of these sutures may compromise the anastomosis itself. We have described here how manual anastomosis in deep, hard to reach surgical fields can be better accomplished with the use of an instrument‐holding clip. Use of the described instrument‐holding clip, to clearly delineate and anchor each suture in sequence, eliminates these problems. An easily available device, it can save operative time, facilitate a more even anastomosis, and decrease the chance of bowel wall tearing, thus enhancing the security of the anastomosis. © 1992 Wiley‐Liss, Inc.
Metachronous second primary malignant fibrous histiocytoma in two skeletal muscles
Authors: Nathanson S. David , Zarbo Richard J. , Sarantou Terry 
Published: February 2007

AbstractThe first recorded case of a metachronous second primary malignant fibrous histiocytoma (MFH) of soft tissue is presented. The patient, who has been followed every two months since the treatment of his buttock sarcoma by neoadjuvant therapy, is free of disease 24 months later. The clinical presentations, different histologies, and DNA contents of these two MFHs are consistent with metachronous primary sarcomas. The literature on second primary neoplasms is discussed. © 1992 Wiley‐Liss, Inc.
Immediate mandibular stabilization following resection of advanced oral cavity carcinoma using the Joe hall morris external fixation device
Authors: Midis Gregory P. , Feuer Adine , Bergman Stewart A. , Elias E. George , Lefor Alan T. , Didolkar Mukund S. 
Published: February 2007

AbstractInternal mandibular fixation after resection of advanced oral cavity carcinoma with mandibulectomy has a significant complication rate. We placed the Joe Hall Morris (JHM) external mandibular appliance in 29 patients undergoing mandibulectomy for advanced oral cavity carcinoma. Fourteen patients received postoperative radiation therapy (RT). Three of 29 patients (10%) had complications associated with the JHM appliance: one patient had a broken connecting bar, a second had loosening of a single pin, and a third had loss of fixation requiring complete replacement of the appliance. Complications not associated with the appliance occurred in 8 patients (28%) including mandibular exposure (1), orocutaneous fistula (2), partial flap dehiscence (4), and flap necrosis (1). Oral continence was maintained in 26 patients, and occlusion was normal in 27. The appliance was removed in 12 weeks to 6 months in all patients. The JHM appliance allows for a reliable and rapid immediate fixation of the mandible with acceptable functional and aesthetic results, and no delay or interference with postoperative radiotherapy. Since the life expectancy of these patients is short, most do not require subsequent permanent fixation after removal of the appliance. © 1992 Wiley‐Liss, Inc.
The influence of hepatic artery ligation and of vasopressin on liver tumour blood flow in rats
Authors: Naredi Peter , Lindér Per , Holmberg Stig B. , Söderberg Rigmor , Carlsson Göran , Gustavsson Bengt , Jacobsson Lars , Hafström Larsolof 
Published: February 2007

AbstractThe blood flow in an experimental adenocarcinoma in the rat liver was determined with the 133Xe‐washout technique before and after hepatic artery ligation (HAL). There was an initial reduction of the washout of 50%. This was further reduced after 1 day by 50%, which was maintained for 7 days. Seven days after HAL or sham procedures the 133Xe‐washout was of similar magnitude in the liver tumours, although after the sham procedure the tumours were larger (3.4 g vs. 1.5 g). The estimated tumour blood flow was then approximately 0.04 ml × min−1 × g−1. The influence on normal liver parenchyma of HAL was a reduction at 30 minutes, which was maintained for 7 days. Postacton®—a synthetic vasopressin—did not influence the 133Xe‐washout in normal liver parenchyma in non‐tumour, as well as in tumour‐bearing animals. There was no influence of Postacton® on the 133Xe‐washout in the liver tumours. Thirty minutes after HAL Postacton® gave a reduction of blood flow in normal liver parenchyma of tumour‐bearing animals, which is thus only from the portal vein. In tumours Postacton® did not significantly reduce the tumour blood flow immediately after HAL. © 1992 Wiley‐Liss, Inc.
Modified presternal esophagogastroplasty in the treatment of esophageal cancer
Authors: Anikin Vladimir A. 
Published: February 2007

AbstractSix male patients with locally advanced esophageal cancer underwent surgical treatment including modified presternal esophagogastroplasty. The main reason for this kind of esophagogastroplasty was anticipated risk of transplant gangrene or anastomotic leak. Esophagoplasty technique provides a possibility for prolonged enteral nutrition and facilitates the further reconstruction in case of partial transplant gangrene. There was no hospital mortality. All patients, despite postoperative complications, began their oral food intake with good tolerance of the regular diet. © 1992 Wiley‐Liss, Inc.
Postoperative adjuvant chemotherapy for operable esophageal cancer: A pilot clinical study
Authors: Sharma Sanjay , D'Cruz Anil K. , Kannan Rajan , Vyas Jatendra J. 
Published: February 2007

AbstractThirty‐eight patients with node positive squamous cell carcinoma of the esophagus were entered into a pilot clinical study using postoperative adjuvant chemotherapy (cisplatinum 100 mg/m2 and methotrexate 150 mg/m2 × 4 cycles) with an intent of improving cure rates and overall survival. Patient compliance was excellent and toxicity minimal. At 24 months of follow‐up 22 patients (58%) were disease free, while 14 patients (37%) have relapsed and 2 were lost to follow‐up. A highly significant correlation was noted between the number of nodes involved, the grade of the tumour, and the response to chemotherapy. Patients with poorly differentiated tumours and those with more than 4 nodes involved were more likely to develop recurrent disease (P < 0.01 and P < 0.005). We conclude that postoperative chemotherapy following resection for carcinoma of the esophagus is well tolerated with minimal side effects. It may also have an impact on improving disease free and overall survival. © 1992 Wiley‐Liss, Inc.
Reasons for non‐entry in randomized clinical trials for breast cancer: A single institutional study
Authors: Kotwall Cyrus A. , Mahoney Leo J. , Myers Robert E. , Decoste Linda 
Published: February 2007

AbstractReasons for patient non‐entry in randomized clinical trials (RCTs) assessing oncologic treatment modalities are not well documented in the literature. We have prospectively recorded reasons for RCT non‐entry in breast cancer patients at St. Michael's Hospital, Toronto. From September 1984 to November 1989, 592 consecutive patients were evaluated through the clinical trials office. One hundred six out of the 592 patients were placed into a RCT (17.9%). Protocol ineligibilities accounted for 273 non‐entries (46.1%) and protocol eligible but not entered patients accounted for 213 (36.0%) non‐entries. The most common reason for protocol ineligibility was advanced age (94 patients). The most common reason for protocol eligible but not entered patients was patient refusal (148 patients). A total of 272 patients in both non‐entered groups were identified as having reasons for non‐entry that were potentially correctable. In summary, protocol ineligibilities account for the majority of non‐entered patients, but patient refusal accounted for the single largest group of potentially correctable non‐entries. More dissemination about the merit of RCTs in the lay press and amongst primary care physicians must take place if we are to expediently and efficiently answer important oncologic questions. © 1992 Wiley‐Liss, Inc.
Cross‐femoral venous bypass in combination with tumor resection
Authors: Radford Diane M. , Walker Howard S. J. 
Published: February 2007

AbstractThe cross‐femoral venous bypass procedure (also known as the Palma/Dale procedure) was introduced for unilateral iliac or common femoral vein occlusions resulting in chronic deep venous insufficiency. We have utilized the procedure successfully in a patient who required extensive pelvic tumor resection involving sacrifice of pelvic venous collateral channels and unilateral ligation of external, internal, and common iliac veins. The case report and review of the literature are presented. © 1992 Wiley‐Liss, Inc.
Primary malignant tumors of the small intestine: Analysis of 40 Japanese patients
Authors: Kusumoto Hiroki , Takahashi Ikuo , Yoshida Motofumi , Maehara Yoshihiko , Watanabe Akihiro , Oshiro Tatsuo , Sugimachi Keizo 
Published: February 2007

AbstractForty Japanese patients with primary malignant tumors of the small intestine were reviewed. Adenocarcinoma was the most common tumor type comprising 19 patients (47%), followed by malignant lymphoma, 11 (30%), leiomyosarcoma, 8 (20%) and carcinoid tumor, 1 (3%). Adenocarcinomas and leiomyosarcomas were primarily located in the duodenum or jejunum, whereas lymphomas were more common in the jejunum or ileum. Abdominal pain (65%) and nausea or vomiting (35%) were the most common symptoms with these tumors. Barium contrast studies were able to detect 83% of these tumors. Our results also suggest that computed tomography and ultrasonography are not reliable for diagnosing jejunal tumors while superior mesenteric angiography is effective for diagnosing ileal tumors. The duodenal and ileal tumors tended to metastasize to lymph nodes while jejunal ones tended to penetrate the serosa or to disseminate into the peritoneal cavity. The percentage of tumors potentially cured by surgery and the 5 year survival rates of the leiomyosarcomas (75% and 57%, respectively) were higher than those of adenocarcinomas (42% and 10%, respectively) and lymphomas (42% and 32%, respectively). © 1992 Wiley‐Liss, Inc.
Adjuvant immunotherapy in melanoma: A new approach
Authors: Elias E. George , Tomazic Vesna J. , Buda Barbara S. 
Published: February 2007

AbstractPatients with metastatic cutaneous melanoma to two or more regional lymph nodes have an extremely poor prognosis despite radical lymphadenectomy. In an attempt to improve the survival and to determine the safety of a new method of tumor specific adjuvant immunotherapy in such a high risk group of patients, nine patients were studied. Three to four weeks after regional lymphadenectomy, each of them received a single intradermal injection of Bacillus Calmette‐Guérin. Three weeks later, they were immunized by allogenic melanoma cells obtained from live donors with distant metastases. Each patient received three vaccinations, each from a different donor (except in one), to avoid development of HLA response, but maintaining exposure to melanoma antigens. No cultured melanoma cells were used. Each vaccine consisted of mitomycin‐C treated tumor cells mixed with purified protein derivative (PPD) of tuberculin given intradermally once per month for 3 months. The patients were then observed with no further treatment. Utilizing the leukocyte migration inhibition test, there was some in vitro evidence of tumor specific cell mediated response which seemed to disappear 1–2 months postimmunization. At 5 years, five of the nine patients (55%) were alive free of disease. No autoimmune diseases were detected in any of the immunized patients. A major hindering factor for such an approach was the limited availability of the allogenic melanoma cells. © 1992 Wiley‐Liss, Inc.
Determination of the resection line in early esophageal cancer using intraoperative endoscopic examination with lugol staining
Authors: Kuwano Hiroyuki , Kitamura Kaoru , Baba Kinya , Morita Masaru , Matsuda Hiroyuki , Mori Masaki , Sugimachi Keizo 
Published: February 2007

AbstractDetermination of the resection line using intraoperative endoscopic examination with Lugol staining was performed when preoperative examinations such as an esophagogram could not be effectively carried out and the carcinoma was not palpable from the outer surface of the esophageal wall. During the past two years, we performed this technique on eight patients. The carcinoma was restricted within the epithelium in one, the mucosal layer in five, and the submucosal layer in two. Although intraepithelial carcinoma contiguous to the main lesion was seen in six and cancer multiplicity was evident in two, all of the resected stumps were free of any cancer tissue. There have been no cases of recurrence and a limited operation, such as distal esophagectomy, was able to be performed in six. Therefore, intraoperative endoscopic examination is useful for early esophageal cancer. © 1992 Wiley‐Liss, Inc.
Comparison of flow cytometric dna content in primary gastric carcinoma and metastases
Authors: Umehara Yasuhiko , Kimura Taizou , Yoshida Masayuki , Oba Noriyuki , Harada Yukio 
Published: February 2007

AbstractNuclear DNA contents were comparatively determined by flow cytometry in primary and metastatic lesions from 112 cases with stomach cancer. Aneuploidy frequency and mean DNA index were higher in lymph node metastatic lesions than in primary lesions, both resected synchronously. In these lymph node metastatic lesions, DNA ploidy patterns did not change in 79% (89/112 cases), and did change in 21% (23/112 cases). Concordance of the DNA index between primary lesions and synchronous liver metastatic lesions was seen in 63% (5/8 cases), but the concordance rate was only 25% (4/16 cases) for primary lesions and metachronous liver metastatic lesions and 0% (0/8) for primary lesions and lung metastases. DNA ploidy changes in metastatic lesions were marked in distal metastatic lesions, or more marked in metachronous metastases than in synchronous ones. The results of the present study suggested the possibility of detecting changes in biological characteristics of metastatic lesions by flow cytometric DNA analysis. © 1992 Wiley‐Liss, inc.
Thyroid and thymic malignancy following childhood irradiation
Authors: Jensen Mark O. , Antonenko David 
Published: February 2007

AbstractSynchronous thyroid and thymic malignancy following childhood thymic irradiation has only been reported in two known cases previously, with a third case identified here. A rationale is presented for following these radiated patients as they age with thyroglobulin and thyroid‐stimulating hormone (TSH) levels as a measure of risk of the development of nodular thyroid disease and, if such occurs, for an aggressive surgical approach. There exists a growing population at risk atributable to the success of radiation treatment of Hodgkin's and pediatric head and neck tumors. The question is raised regarding the theoretical benefits of thyroid suppressive therapy in this group at risk. With the instructive case presented, radical surgery for either thymic or thyroid carcinoma and careful monitoring for decades‐late local recurrences of thymoma are suggested. © 1992 Wiley‐Liss, Inc.