bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potencial de malignização da leucoplasia oral: relato de caso clínico e revisão integrativa da literatura
Authors: Silva Danilla Natally Mendonça , Béda Nathalia Silva , Gramacho Ysabella Dhorcas Santos , Lima Sara Lia Gonçalves de 
Published: April 2024

A leucoplasia é uma doença caracterizada geralmente por manchas ou placas brancas, provocada pelo crescimento celular excessivo, que surge na mucosa oral, acometendo principalmente a gengiva ou mucosa jugal. Sendo, altamente prevalente no mundo todo, embora muitas das vezes seja assintomática, é preocupante devido seu potencial de malignização, desta maneira, é imprescindível aprofundar os conhecimentos por meio do estudo da literatura quanto suas características clínicas e principalmente no risco de potencial de malignização, permitindo dessa forma, uma compreensão clara, acerca dos fatores de risco, características clínicas, risco de malignização e abordagens terapêuticas para o manejo eficaz dessa condição. Este trabalho tem como objetivo relatar um caso clínico, no qual, foi correlacionado com uma revisão integrativa de literatura acerca do potencial de malignização da leucoplasia oral. Paciente J.L.S, sexo masculino, 51 anos, tabagista a mais de trinta anos compareceu à clínica de diagnóstico da faculdade INTEGRA, com placas leucoplasicas em mucosa jugal, alvéolo posterior e gengiva sugestivas clinicamente de leucoplasia oral. As lesões eram assintomáticas e com tempo de surgimento indeterminado. Foi realizado a primeira biópsia incisional com resultado histopatológico de leucoplasia com displasia epitelial leve. Diante dos hábitos do paciente e diagnóstico clínico/histopatológico foi realizado acompanhamento clínico de 6 em 6 meses durante três anos. Foram realizadas buscas em bases de dados eletrônicas para identificar artigos que descrevam paciente(s) com leucoplasia oral com restrição de tempo no PubMed em agosto de 2022.
Discussion on Four-Step Method to Improve Practical Ability of Undergraduate Power Electronics Technology Course
Authors: Zhuo Chaoran , Li Ning , Ji Junpeng 
Published: April 2024

The course of power electronics technology is a required professional basic course for most students of electrical engineering colleges in Colleges of science and engineering. Due to its wide range of contents, many complex circuits, and various waveform analysis methods, it has always been a course that students find difficult to master, and the course content is closely integrated with the industry, with fast update speed and strong practicality, how to do well in the teaching of this course has always been the concern of teachers. The author combines the specific teaching process of the course in his school, aiming how to enable students to master the core points of the course effectively, and from the perspective of practical teaching, divides the practical teaching process into four steps: perception, basic experiment, simulation, and engineering design, to gradually guide students to master the core content of the course from shallow to deep, to meet the talent requirements put forward by the technological development of industry.
Unified Expression and Standardized Treatment of Railway Supergene Geological Disaster Risk Information
Authors: Cui Mengzhen , Jiao Wenwen , Li Congxu , Wang Xueying 
Published: April 2024

Aiming at the problem that railway supergene geological disaster risk data are scattered and heterogeneous, and it is difficult to unify and centralize management and fusion analysis, the multi-source and heterogeneous supergene geological disaster risk data are standardized and integrated, and based on ontology theoretical knowledge, the digital model of main risk factors such as geography, geology, facilities and meteorology and their relationship is constructed to realize the unified expression of geological disaster riskinformation; Then, a standardized processing method of geological disaster risk data is proposed to realize three-dimensional modeling of geography and geology of railway facilities, and accurately extract multi-factor semantic features of disasters such as location and scope, and gather multi-source dynamic monitoring data such as displacement and meteorology, which provides key data support for scene analysis and visual expression of railway supergene geological disasters. Finally, landslide geological disasters around typical railway lines are selected for experimental verification and analysis, which proves that this method is reasonable and effective.
Biuret doping is used to improve the performance of organic/inorganic photodetectors
Authors: Zhang Qiyue , Hu Yang 
Published: April 2024

The combination of inorganic semiconductor materials and perovskite materials can improve the performance and stability of photodetectors, and the photodiode prepared by combining Zinc oxide (ZnO) materials and perovskite materials can realize a wide spectrum detection from ultraviolet to near infrared. As the electron transport layer, ZnO film forming quality is very important to improve the performance of photodetectors. Therefore, in order to improve the film forming quality of ZnO, the surface passivation of ZnO films was prepared by doping Biuret into ZnO precursor solution, and its effects on the device working mechanism and device performance were studied. Studies have shown that doping Biuret improves the film forming quality of ZnO, and thus improves the electron transport capacity of ZnO. Meanwhile, the interface contact between ZnO film and perovskite film is optimized, and the film forming quality of perovskite is also improved. The light detection performance of the photodiode prepared by the combination of ZnO material and perovskite material is greatly improved, and the dark current of the device is obviously reduced, which is about 1/5 of the undoped Biuret device. Compared with undoped Biure device, the doped Biure device obtains the photoresponsivity (R) of 17740 mA/W, an increase of about three times. the specific detectivity (D*) has been increased to 1.27×1013 Jones, an order of magnitude higher than before.
The Criteria for Selecting Outstanding Traditional Building Craftsmen in China Based on Interpretative Structural Modeling
Authors: Lan Keran , Hsu Wei-Ling , Mou Lin 
Published: April 2024

With the implementation of policies promoting the revival of traditional Chinese culture, traditional buildings are gaining increasing attention. Traditional craftsmen have become central to the protection of traditional buildings, and various regions are conducting selections for outstanding traditional building craftsmen. The objective is to establish leaders in the industry and promote the conservation and restoration of traditional buildings.Currently, the selection of outstanding craftsmen in traditional building mostly relies on descriptive criteria, making it difficult to define clearly and posing challenges to the selection process. This article, based on existing selection standards, utilizes expert questionnaires to establish an interpretative structural model for the criteria for selecting traditional building craftsmen. This model clarifies the relationships between selection conditions, providing a reference for the selection of outstanding craftsmen in traditional buildings and helping the revival of traditional architectural culture and heritage protection.
Neutron Radiation-induced Damage to the Local Structure and Optical Properties of Amorphous Phase-Change Materials
Authors: Rao Kai , Wang Yinghao 
Published: April 2024

Phase change materials are being developed for aerospace applications due to their unique storage mechanisms and excellent optical storage performance, where radiation damage is an issue that needs to be addressed. This paper used a 300 KeV neutron beam to irradiate amorphous Ge2Sb2Te5 (a-GST) films, the radiation damage to the local structure and optical properties of a-GST were studied. The results showed that neutron radiation partially damaged the Ge-Te and Sb-Te, causing changes in the values and distribution of the refractive index, but had a lesser impact on reflectivity. Good neutron radiation tolerance was exhibited by a-GST.
Evaluación de vulnerabilidad sísmica en edificio municipal de Shushufindi según normativa y parámetros oficiales
Authors: Durán Sánchez Fernando Antonio , Durán Sánchez Carmen Alexandra 
Published: April 2024

El presente Artículo trata de contrastar parámetros establecidos en normativas nacionales como la Norma Ecuatoriana de la Construcción NEC-2015; normas internacionales como el ATC-40, FEMA-273, FEMA 360, las cuales brindan recomendaciones necesarias para la evaluación de vulnerabilidad estructural de una forma analítica destacándose el desarrollo del espectro de respuesta Estructural en función del espectro sísmico con el cual fue diseñado, de igual manera el espectro de Capacidad con el fin de evidenciar cuál será el comportamiento estructural del sistema estructural analizado teniendo como base que dicha estructura está configurada por medio de pórticos y cimentación de hormigón armado y divisiones de mampostería. En el cual se pudo verificar que el funcionamiento de este edificio será óptimo ante un sismo ya que su desempeño garantiza que es una estructura segura ubicándose su punto de capacidad entre el punto B e IO que quiere decir que luego de un sismo El nivel de desempeño de la estructura está ubicado entre el punto IO y el LS es decir el edificio luego de un sismo tendrá daños estructurales leves y daños en mampostería graves, además por tratarse de una estructura con vigas banda se prevé la existencia de fisuras en las losas así como el pandeo de las misma, y si existen réplicas sísmicas podría ocasionar el colapso de la estructura.
Representations of algebras satisfying a train identity of degree 2 and exponent 3
Authors: Lallou Harouna , Savadogo Souleymane , Conseibo André 
Published: April 2024

In this paper, we are interested in the study of representations of the algebras A satisfying the equation (a3)2 = ω(a3)a3, for all a in A. We give a characterization of these representations. We also give the condition under which the A-module is associative. When the Peirce component A1/2= 0, we give examples of sub A-modules. We show that the irreducible A-submodules are not necessarily of dimension 1.
Pharmacometric in silico studies used to facilitate a national dose standardisation process in neonatology – application to amikacin
Authors: Gotta Verena , Bielicki Julia Anna , Paioni Paolo , Csajka Chantal , Bräm Dominic Stefan , Berger Christoph , Giger Elisabeth , Buettcher Michael , Posfay-Barbe Klara M. , Van den Anker John , Pfister Marc 
Published: April 2024

BACKGROUND AND AIMS: Pharmacometric in silico approaches are frequently applied to guide decisions concerning dosage regimes during the development of new medicines. We aimed to demonstrate how such pharmacometric modelling and simulation can provide a scientific rationale for optimising drug doses in the context of the Swiss national dose standardisation project in paediatrics using amikacin as a case study.
METHODS: Amikacin neonatal dosage is stratified by post-menstrual age (PMA) and post-natal age (PNA) in Switzerland and many other countries. Clinical concerns have been raised for the subpopulation of neonates with a post-menstrual age of 30–35 weeks and a post-natal age of 0–14 days (“subpopulation of clinical concern”), as potentially oto-/nephrotoxic trough concentrations (Ctrough >5 mg/l) were observed with a once-daily dose of 15 mg/kg. We applied a two-compartmental population pharmacokinetic model (amikacin clearance depending on birth weight and post-natal age) to real-world demographic data from 1563 neonates receiving anti-infectives (median birth weight 2.3 kg, median post-natal age six days) and performed pharmacometric dose-exposure simulations to identify extended dosing intervals that would ensure non-toxic Ctrough (Ctrough <5 mg/l) dosages in most neonates.
RESULTS: In the subpopulation of clinical concern, Ctrough <5 mg/l was predicted in 59% versus 79–99% of cases in all other subpopulations following the current recommendations. Elevated Ctrough values were associated with a post-natal age of less than seven days. Simulations showed that extending the dosing interval to ≥36 h in the subpopulation of clinical concern increased the frequency of a desirable Ctrough below 5 mg/l to >80%.
CONCLUSION: Pharmacometric in silico studies using high-quality real-world demographic data can provide a scientific rationale for national paediatric dose optimisation. This may increase clinical acceptance of fine-tuned standardised dosing recommendations and support their implementation, including in vulnerable subpopulations.
Analysis of Biochemical and Histological Indicators in the Blood Serum and Organs of Rats during Prolonged Oral Administration of Food Additive E 102 (Tartrazine)
Authors: I. Gubina-Vakulik Galina , V. Gorbach Tatyana , O. Vekshyn Vitalii 
Published: April 2024

The food azo dye tartrazine (Е102) is not metabolized in humans, and it is excreted unchanged through the kidneys. A study was carried out on the biochemical and histological features in the kidneys of rats, as well as the biochemical features in the blood and urine during long-term use of tartrazine E102 (1 ml of 0.1% solution per 100 g of animal weight daily). In the first experiment, animals received a solution of tartrazine from 1 month up to 3 months age per os; in the second experiment, individuals received tartrazine first transplacentally (in utero), then with mother’s milk, and during 1 month only with food. In the animals of the first experiment, the biochemical changes are not profound, and it is morphologically shown that the losses of the parenchyma and stroma of the kidney are compensated and regenerated. In the second experiment, oxidative stress and signs of chronic glomerulonephritis and chronic tubulointerstitial nephritis were detected against the background of disorders of intrauterine kidney development.
Implementasi Proyek Penguatan Profil Pelajar Pancasila Berbasis Al-Islam Kemuhammadiyahan di Sekolah Menengah Atas Muhammadiyah 2 Surakarta
Authors: Innayah Sabarniati Kunti , Istanto  
Published: April 2024

Salah satu penerapan Kurikulum Merdeka yaitu mengadakan pembelajaran berbasis proyek, yang dimana pembelajaran tersebut bertujuan untuk menanamkan karakter pancasila kepada peserta didik. Penelitian ini bertujuan untuk menganalisis pelaksanaan Proyek Penguatan Profil Pelajar Pancasila Berbasis Al-Islam Kemuhammadiyahan di SMA Muhammadiyah 2 Surakarta. Metode yang digunakan dalam penelitian ini yaitu metode penelitian kualitatif. Subjek dalam penelitian ini yaitu koordinator pelaksanaan Proyek Penguatan Profil Pelajar Pancasila dan peserta didik SMA Muhammadiyah 2 Surakarta. Dalam mengumpulkan data peneliti melaksanakan observasi, wawancara, dan dokumentasi. Adapun hasil dari yang peneliti laksanakan yaitu SMA Muhammadiyah 2 Surakarta menerapkan kurikulum merdeka, dan merupakan sekolah penggerak. Implementasi Proyek Penguatan Profil Pelajar Pancasila diawali dengan tahap perencanaan, pelaksanaan, dan juga evaluasi. Semua warga sekolah yang terdiri dari peserta didik, wali murid, serta seluruh warga sekolah sangat antusias dalam mengikuti kegiatan P5. Kegiatan Proyek Penguatan Profil Pelajar Pancasila ini terdapat tiga tema yaitu “gaya hidup berkelanjutan”, “kearifan lokal”, dan “suara demokrasi”. Terdapat nilai-nilai yang dapat diambil setelah adanya Proyek Penguatan Profil Pelajar Pancasila mulai dari gotong royong, kemandirian, kerjasama, serta meningkatnya partisipasi peserta didik terhadap kegiatan di sekolah. Selain itu juga dapat memberikan nilai-nilai yang positif yang sejalan dengan Al-Islam dan Kemuhammadiyahan sehingga peserta peserta didik dapat menerapkan nilai kesabaran, keadilan, kejujuran, tanggung jawab dalam aktivitas kesehariannya.
Opinie uczestników na temat funkcjonowania Pracowniczych Planów Kapitałowych w Polsce
Authors: Garbiec Roman 
Published: April 2024

Wiedza Polaków o nowym systemie emerytalnym jest znikoma. Niewiele osób zdaje sobie sprawę, że emerytury publiczne będą na poziomie nie zabezpieczającym przeżycia osobom starszym. Podejmowane od 2004 roku działania modernizacyjne w tym systemie także istotnie nie zmieniają stanu wiedzy na ten temat. Kolejna decyzja o wprowadzeniu w Polsce Pracowniczych Planów Kapitałowych (PPK), będącego elementem III filaru emerytalnego, nie poprawiła wiedzy społeczeństwa w tym zakresie.
Niniejszy artykuł prezentuje opinie uczestników (pracowników) na temat funkcjonowania PPK, gdzie podstawą ich sprecyzowania było badanie ankietowe przeprowadzone wśród 821 pracowników, którzy podjęli decyzje o uczestniczeniu w planie.
Jak wynika z przeprowadzonego badania uczestników PPK, propozycja ta spotyka się z ambiwalentnym przyjęciem, ze względu na błędy w propagowaniu zachęt do przystąpienia i dostrzegane przez respondentów wady wprowadzonego rozwiązania.
Słowa kluczowe: Pracowniczy Plan Kapitałowy (PPK), trzeci filar emerytalny, uczestnicy Pracowniczego Planu Kapitałowego, wady i zalety PPK.
Sustainable Solutions: Holistic Strategies For Electric Vehicle Adoption And Transportation Sustainability
Authors: Vinay Kumar , Yogita Sharma , Priyanka Chadha  
Published: April 2024

This research provides a thorough examination of marketing techniques in the electric vehicle (EV) business, utilizing several bibliometric indicators, trends in author productivity, and country-specific data. The data reveals an apparent rise in research focus and the influence of citations around the year 2020, followed by a subsequent decrease in future years. It also examines the specific effects of different sources, highlighting the significant influence of scholarly journals like the "Journal of Power Sources" and "Sustainability (Switzerland)" in shaping discussions around electric vehicle marketing. The analysis of commonly appearing terms and networks of word associations uncovers essential research topics like marketing tactics, sustainability, business trends, and consumer conduct. Our report provides useful insights into the changing landscape of EV market research and suggests future directions for both scholars and practitioners. Our goal is to provide a clear guide for understanding and navigating the complex world of EV marketing. We emphasize the importance of considering multiple disciplines and recommend comprehensive tactics to promote the adoption of EVs and develop sustainable transportation solutions.
Exploring Early Eocene Hyperthermals on the New Jersey Paleoshelf (ODP 174AX)
Authors: Fung Megan K. , Katz Miriam E. , Miller Kenneth G. , Browning James V. , Schaller Morgan F. 
Published: April 2024

Abstract
We investigate early Eocene hyperthermals by complementing foraminiferal and bulk carbonate isotopes with benthic foraminiferal assemblages from three marine coreholes located along a paleoshelf transect on the New Jersey coastal plain (ODP 174AX Bass River, Double Trouble, and Ancora). Distinct negative δ13C and δ18O excursions likely correspond to the globally documented ETM-2, H2, I1, I2, and J events. Foraminiferal stable isotope data at Bass River reveal greater warming in benthic and thermocline communities compared to the surface dwellers during these excursion events. During the largest excursion event (ETM-2), thermocline-dwelling Subbotina not only experienced greater overall warming, but also recorded lower δ18O values than Morozovella (–5.1‰ vs. –4.3‰). This suggests either greater warming in the thermocline, habitat depth restructuring, or possibly a change in calcification season. We also demonstrate a potential biotic threshold, providing the first comprehensive evaluation of the sensitivity of shallow-marine taxa in response to these transient warming events.
S100A8/9 modulates perturbation and glycolysis of macrophages in allergic asthma mice
Authors: Ji Xiaoyi , Nie Chunhua , Yao Yuan , Ma Yu , Huang Huafei , Hao Chuangli 
Published: April 2024

Background
Allergic asthma is the most prevalent asthma phenotype and is associated with the disorders of immune cells and glycolysis. Macrophages are the most common type of immune cells in the lungs. Calprotectin (S100A8 and S100A9) are two pro-inflammatory molecules that target the Toll-like receptor 4 (TLR4) and are substantially increased in the serum of patients with severe asthma. This study aimed to determine the effects of S100A8/A9 on macrophage polarization and glycolysis associated with allergic asthma.

Methods
To better understand the roles of S100A8 and S100A9 in the pathogenesis of allergic asthma, we used ovalbumin (OVA)-induced MH-S cells, and OVA-sensitized and challenged mouse models (wild-type male BALB/c mice). Enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction, flow cytometry, hematoxylin-eosin staining, and western blotting were performed. The glycolysis inhibitor 3-bromopyruvate (3-BP) was used to observe changes in glycolysis in mice.

Results
We found knockdown of S100A8 or S100A9 in OVA-induced MH-S cells inhibited inflammatory cytokines, macrophage polarization biomarker expression, and pyroptosis cell proportion, but increased anti-inflammatory cytokine interleukin (IL)-10 mRNA; also, glycolysis was inhibited, as evidenced by decreased lactate and key enzyme expression; especially, knockdown of S100A8 or S100A9 inhibited the activity of TLR4/myeloid differentiation primary response gene 88 (MyD88)/Nuclear factor kappa-B (NF-κB) signaling pathway. Intervention with lipopolysaccharides (LPS) abolished the beneficial effects of S100A8 and S100A9 knockdown. The observation of OVA-sensitized and challenged mice showed that S100A8 or S100A9 knockdown promoted respiratory function, improved lung injury, and inhibited inflammation; knockdown of S100A8 or S100A9 also suppressed macrophage polarization, glycolysis levels, and activation of the TLR4/MyD88/NF-κB signaling pathway in the lung. Conversely, S100A9 overexpression exacerbated lung injury and inflammation, promoting macrophage polarization and glycolysis, which were antagonized by the glycolysis inhibitor 3-BP.

Conclusion
S100A8 and S100A9 play critical roles in allergic asthma pathogenesis by promoting macrophage perturbation and glycolysis through the TLR4/MyD88/NF-κB signaling pathway. Inhibition of S100A8 and S100A9 may be a potential therapeutic strategy for allergic asthma.