bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observations of Atmospheric Structure and Dynamics in the Owens Valley of California with a Ground-Based, Eye-Safe, Scanning Aerosol Lidar*
Authors: De Wekker Stephan F. J. , Mayor Shane D. 
Published: January 2009

AbstractFirst results are presented from the deployment of the NCAR Raman-Shifted Eye-Safe Aerosol Lidar (REAL) in the Owens Valley of California during the Terrain-Induced Rotor Experiment (T-REX) in March and April 2006. REAL operated in range–height indicator (RHI) and plan position indicator (PPI) scanning modes to observe the vertical and horizontal structures of the aerosol and cloud distribution in a broad valley in the lee of a tall mountain range. The scans produce two-dimensional cross sections that when animated produce time-lapse visualizations of the microscale and mesoscale atmospheric structures and dynamics. The 2-month dataset includes a wide variety of interesting atmospheric phenomena. When the synoptic-scale flow is strong and westerly, the lidar data reveal mountain-induced waves, hydraulic jumps, and rotorlike circulations that lift aerosols to altitudes of more than 2 km above the valley. Shear instabilities occasionally leading to breaking waves were observed in cloud and aerosol layers under high wind conditions. In quiescent conditions, the data show multiple aerosol layers, upslope flows, and drainage flows interacting with valley flows. The results demonstrate that a rapidly scanning, eye-safe, ground-based aerosol lidar can be used to observe important features of clear-air atmospheric flows and can contribute to an improved understanding of mountain-induced meteorological phenomena. The research community is encouraged to use the dataset in support of their observational analysis and modeling efforts.
Passive Microwave Brightness Temperatures as Proxies for Hailstorms
Authors: Cecil Daniel J. 
Published: January 2009

Abstract
The Tropical Rainfall Measuring Mission (TRMM) satellite has been used to infer distributions of intense thunderstorms. Besides the lightning measurements from TRMM, the radar reflectivities and passive microwave brightness temperatures have been used as proxies for convective vigor. This is based on large graupel or hail lofted by strong updrafts being the cause of high–radar reflectivity values aloft and extremely low brightness temperatures. This paper seeks to empirically confirm that extremely low brightness temperatures are often accompanied by large hail at the surface. The three frequencies examined (85, 37, and 19 GHz) all show an increasing likelihood of hail reports with decreasing brightness temperature. Quantification is limited by the sparsity of hail reports. Hail reports are common when brightness temperatures are below 70 K at 85 GHz, 180 K at 37 GHz, or 230 K at 19 GHz.
Stratospheric Temperature and Radiative Forcing Response to 11-Year Solar Cycle Changes in Irradiance and Ozone
Authors: Gray L. J. , Rumbold S. T. , Shine K. P. 
Published: January 2009

Abstract
The 11-yr solar cycle temperature response to spectrally resolved solar irradiance changes and associated ozone changes is calculated using a fixed dynamical heating (FDH) model. Imposed ozone changes are from satellite observations, in contrast to some earlier studies. A maximum of 1.6 K is found in the equatorial upper stratosphere and a secondary maximum of 0.4 K in the equatorial lower stratosphere, forming a double peak in the vertical. The upper maximum is primarily due to the irradiance changes while the lower maximum is due to the imposed ozone changes. The results compare well with analyses using the 40-yr ECMWF Re-Analysis (ERA-40) and NCEP/NCAR datasets. The equatorial lower stratospheric structure is reproduced even though, by definition, the FDH calculations exclude dynamically driven temperature changes, suggesting an important role for an indirect dynamical effect through ozone redistribution. The results also suggest that differences between the Stratospheric Sounding Unit (SSU)/Microwave Sounding Unit (MSU) and ERA-40 estimates of the solar cycle signal can be explained by the poor vertical resolution of the SSU/MSU measurements. The adjusted radiative forcing of climate change is also investigated. The forcing due to irradiance changes was 0.14 W m−2, which is only 78% of the value obtained by employing the standard method of simple scaling of the total solar irradiance (TSI) change. The difference arises because much of the change in TSI is at wavelengths where ozone absorbs strongly. The forcing due to the ozone change was only 0.004 W m−2 owing to strong compensation between negative shortwave and positive longwave forcings.
Linear Contributions of Different Time Scales to Teleconnectivity
Authors: Athanasiadis Panos J. , Ambaum Maarten H. P. 
Published: January 2009

Abstract
The contributions of different time scales to extratropical teleconnections are examined. By applying empirical orthogonal functions and correlation analyses to reanalysis data, it is shown that eddies with periods shorter than 10 days have no linear contribution to teleconnectivity. Instead, synoptic variability follows wavelike patterns along the storm tracks, interpreted as propagating baroclinic disturbances. In agreement with preceding studies, it is found that teleconnections such as the North Atlantic Oscillation (NAO) and the Pacific–North America (PNA) pattern occur only at low frequencies, typically for periods more than 20 days. Low-frequency potential vorticity variability is shown to follow patterns analogous to known teleconnections but with shapes that differ considerably from them. It is concluded that the role, if any, of synoptic eddies in determining and forcing teleconnections needs to be sought in nonlinear interactions with the slower transients. The present results demonstrate that daily variability of teleconnection indices cannot be interpreted in terms of the teleconnection patterns, only the slow part of the variability.
A Perpetually Running ENSO in the Pliocene?
Authors: Wunsch Carl 
Published: January 2009

AbstractDifficulties remain with theoretical explanations of the apparent reduced zonal sea surface temperature gradient in the tropical Pacific of the Pliocene. One favored hypothesis is that it was a “permanent El Niño” state, with the warm phase of ENSO remaining fixed over millions of years. Here, an alternative is suggested—that there was a “perpetually running ENSO” with a shorter return time than is observed today, and that the apparently reduced zonal gradient is an alias–rectification of a high-frequency signal governed by the growth patterns of the foraminifera used to provide proxy temperatures. The hypothesis is probably testable in the modern ocean with comparatively modest measurements of foraminifera behavior in time.
A New High-Resolution Satellite-Derived Precipitation Dataset for Climate Studies
Authors: Joseph Renu , Smith Thomas M. , Sapiano Mathew R. P. , Ferraro Ralph R. 
Published: January 2009

Abstract
The importance of analyzing climate at high spatiotemporal resolution has been emphasized in the recent Intergovernmental Panel on Climate Change (IPCC) report. Several high-resolution analyses of global precipitation have recently been created to meet this need by combining high-quality passive microwave estimates with frequently sampled geosynchronous infrared estimates. A new daily 0.25° analysis has been developed at the Cooperative Institute for Climate Studies (CICS), called the CICS High-Resolution Optimally Interpolated Microwave Precipitation from Satellites (CHOMPS), which is based only on passive microwave satellite estimates. The analysis was developed using all available sensors and the most up-to-date common retrieval scheme. An important advantage of CHOMPS is, therefore, its consistency. The microwave estimates from the different sensors at hourly time scales are combined using optimum interpolation (OI), using estimates of the noise and spatial correlation scales and standardized analysis weights. This technique reduces the random errors while still capturing the tails of the distribution of precipitation and provides estimates of output error based on the noise-to-signal ratio of the inputs. Hourly values are combined to produce a daily average and error estimate. Evaluation of CHOMPS against surface-based observational data, such as the stage IV radar and the Tropical Atmosphere Ocean (TAO)/Triangle Trans-Ocean Buoy Network (TRITON) gauges, indicates that CHOMPS performs well, especially when compared to other high-resolution products. This analysis, therefore, highlights OI as a feasible methodology for the creation of a high-resolution precipitation product. The analysis begins in 1998 and has thus far been continued through 2007, making it a useful dataset to examine intraseasonal variability. When the period of the data becomes long enough, it will prove to be a useful dataset to study longer modes of climate variability.
Spectral Bias Estimation of Historical HIRS Using IASI Observations for Improved Fundamental Climate Data Records
Authors: Cao Changyong , Goldberg Mitch , Wang Likun 
Published: January 2009

Abstract
A prerequisite for climate change detection from satellites is that the measurements from a series of historical satellites must be consistent and ideally made traceable to the International System of Units (SI). Unfortunately, this requirement is not met for the 14 High Resolution Infrared Radiation Sounders (HIRS) on the historical NOAA satellites, because the instrument was developed for weather forecasts and lacks accuracy and consistency across satellites. It is well known that for HIRS, differences in the spectral response functions (SRF) between instruments and their prelaunch measurement uncertainties often lead to observations of the atmosphere at different altitudes. As a result of the atmospheric lapse rate, they both can introduce significant intersatellite biases. The SRF-dependent biases are further mixed with other effects such as the diurnal cycle because of observation time differences and orbital drifts, on board calibration, and algorithm issues. In this study, the Infrared Atmospheric Sounding Interferometer (IASI) observations are used to calculate the radiances for the 14 Television Infrared Observation Satellite series N (TIROS-N; to MetOp-A) HIRS instruments in different climate regimes and seasons to separate the SRF-induced intersatellite biases from other factors. It is found that the calculated radiance ratio (a bias indicator) using IASI observations for the HIRS satellite pairs forms bell-shaped curves that vary with the HIRS model and channel as well as climate regimes. This suggests that a bias found in the polar regions at the Simultaneous Nadir Overpass (SNO) cannot be blindly used for bias correction globally; instead, the IASI/HIRS spectral bias bell curves should be used as a complement to more fully address the biases. These bell curves also serve as lookup charts for separating the bias due to true SRF differences from that caused by SRF prelaunch measurement errors to resolve the inconsistency, which sheds new light on reprocessing and reanalysis in generating fundamental climate data records from HIRS.
The optimal therapeutic use of ixabepilone in patients with locally advanced or metastatic breast cancer
Authors: Boehnke Michaud Laura 
Published: January 2009

Background. The epothilones are a new class of microtubule-stabilizing drugs that exert potent antitumor activity against taxane-resistant and multidrug resistant cell lines. The most clinically advanced member of this class is the semisynthetic epothilone B derivative ixabepilone. Purpose. This article reviews the preclinical and clinical data on ixabepilone in patients with locally advanced and metastatic breast cancer (MBC) and provides guidance for pharmacists on its optimal use. Data sources. PubMed and conference proceedings through August 2008. Results. In preclinical studies, ixabepilone has demonstrated potent antitumor activity and low susceptibility to mechanisms that confer tumor resistance. Clinically meaningful benefits have been achieved with ixabepilone monotherapy in phase 2 trials of patients with MBC who have failed previous chemotherapies (anthracyclines, taxanes, or capecitabine). In a randomized, phase 3 trial, the combination of ixabepilone and capecitabine proved more effective than capecitabine alone after the failure of taxane and anthracycline regimens. At the recommended dose and schedule, the therapeutic ratio of ixabepilone is generally favorable, and its adverse effects (notably neutropenia and peripheral neuropathy) are generally manageable and reversible. Conclusion. Ixabepilone represents an advance in the treatment of anthracycline - and taxane-pretreated MBC. Future studies will define its efficacy in combination with other drugs used in the treatment of MBC, as well as in other types of cancer. J Oncol Pharm Practice (2009) 15: 95—106.
Rapid Infusion Rituximab Changing Practice for Patient Care
Authors: Al Zahrani Ali , Ibrahim Nagwa , Al Eid Ahmed 
Published: January 2009

Rituximab is a chimeric anti-CD20 monoclonal antibody. Its intravenous administration is associated with substantial infusion related-toxicity. Recommended infusion durations are prolonged (average 5—6 h for first infusion and 3—4 h for subsequent infusions). We aimed to explore the safety and tolerability of short infusion rituximab, (over 90 min), in Non-Hodgkin’s lymphoma patients at Riyadh Military Hospital. Adult oncology patients diagnosed with Non-Hodgkin’s lymphoma, who were to receive rituximab, were included in the study. The schedule of administration for cycle one was unaltered and delivered according to the product monograph (5—6 h). All subsequent cycles were administered over a total infusion time of 90 min (20% of the dose in the first 30 min then the remaining 80% over 60 min, total dose delivered in 500 mL sodium chloride). All patients were observed for infusion related reactions during the rituximab infusion and for 30 min after the infusion. In addition, all patients were advised to report any reaction occurring within 24 h after rituximab infusion. From April 2007 to September 2007, 21 patients with non-Hodgkin’s lymphoma were treated with rituximab-based chemotherapy. A total of 126 infusions were administered with average of 6 infusions per patient. The majority of patients were treated with CHOP—Rituximab or CHOP-like regimen. The 90-min Rituximab infusion schedule was well tolerated with no grade 3/4 infusion related adverse events observed. A rapid infusion rituximab over 90 min is well tolerated and safe when administered as the second and subsequent infusions in the course of therapy. This shortened infusion schedule has resulted in a substantial reduction in resource utilization. Our institution has adopted this as routine practice.
Patients’ perspectives and safe handling of oral anticancer drugs at an Asian cancer center
Authors: Chan Alexandre , Leow Yumei Cynthia , Sim Mui Hian 
Published: January 2009

Background. In view of the increased usage of oral anticancer drugs in the contemporary treatment of cancer, we aimed to examine cancer patients’ perspectives of oral anticancer drugs, through a survey at an Asian cancer centre. This study also intended to describe patients’ behavior regarding storage, handling, and administration of oral anticancer drugs. Methods. This cross sectional survey was conducted at a single site. The interviewer-administered survey was undertaken at the outpatient pharmacy of National Cancer Centre Singapore (NCCS), the largest ambulatory cancer center in Singapore, between January and March 2008. Eligible patients had received at least one cycle of oral anticancer agent treatment or had been taking oral anticancer agents continuously for 3 months. Results. A total of 126 patients were surveyed. Median age of surveyed patients was 58 years (range 31—85 years). The drugs involved were capecitabine (39.7% of patients), tamoxifen (23.1%), aromatase inhibitors (18.2%), gefitinib (9.1%), and imatinib (3.3%). Over 90% patients self-administered their oral anticancer drugs. The majority of the patients (94.2%) reported no difficulties in adherence to their oral anticancer treatment regimens. Forty per cent of patients reported habitually washing their hands after administering their anticancer drugs. None of the patients, except two patients receiving capecitabine, indicated that they habitually used gloves to handle their oral anticancer medications. Conclusion. The majority of patients receiving oral anticancer agents reported no difficulty in adhering to their oral anticancer treatment regimens as prescribed. However, this survey demonstrated the need to improve patients’ understanding of the requirements for storage, handling and safe administration of oral anticancer drugs.
Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation
Authors: Radke Amy L. , Reynolds Lauren E. , Melo Rossana C. N. , Dvorak Ann M. , Weller Peter F. , Spencer Lisa A. 
Published: January 2009

AbstractEosinophil chemotaxis and survival within tissues are key components in the development of tissue eosinophilia and subsequent effector responses. In this study, we demonstrate a novel mechanism of eosinophil autoregulation affecting migration and survival mediated through Notch signaling. We show for the first time that human blood eosinophils express Notch receptors and Notch ligands, expressions of which are influenced by the presence of eosinophil-activating granulocyte-macrophage colony-stimulating factor (GM-CSF). Evidence of Notch receptor activation and subsequent transcription of the Notch-responsive gene HES1 were observed in GM-CSF–stimulated eosinophils, confirming functionality of eosinophil-expressed Notch-signaling components. Moreover, by inhibiting Notch signaling with γ-secretase inhibitors or Notch receptor–specific neutralizing antibodies, we demonstrate that autocrine Notch signaling enhances stimulus-mediated actin rearrangement and eosinophil chemokinesis, and impairs eosinophil viability. Taken together, these data suggest autocrine Notch signaling, enhanced in response to tissue- or inflammatory-derived signals, influences eosinophil activity and longevity, which may ultimately contribute to the development of tissue eosinophilia and exacerbation or remediation of eosinophil effector functions.
C1q enhances IFN-γ production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells
Authors: Baruah Paramita , Dumitriu Ingrid E. , Malik Talat H. , Cook H. Terence , Dyson Julian , Scott Diane , Simpson Elizabeth , Botto Marina 
Published: January 2009

AbstractDendritic cells (DCs) are known to produce C1q, the initiator of the classical complement pathway. We demonstrate that murine DCs deficient in C1q (C1qa−/−) are poorer than wild-type (WT) DCs at eliciting the proliferation and Th1 differentiation of antigen-specific T cells. These defects result from decreased production of IL-12p70 by C1qa−/− DCs and impaired expression of costimulatory molecules CD80 and CD86 in response to CD40 ligation. The defective production of IL-12p70 and the reduced expression of CD80 and CD86 by C1qa−/− DCs were specifically mediated via CD40 ligation, as normal levels of IL-12p70 and CD80/86 were observed after ligation of Toll-like receptors (TLRs) on C1qa−/− DCs. CD40 ligation on C1qa−/− DCs, but not TLR ligation, results in decreased phosphorylation of p38 and ERK1/2 kinases. A strong colocalization of CD40 and C1q was observed by confocal microscopy upon CD40 ligation (but not TLR ligation) on DCs. Furthermore, human DCs from 2 C1q-deficient patients were found to have impaired IL-12p70 production in response to CD40L stimulation. Our novel data suggest that C1q augments the production of IL-12p70 by mouse and human DCs after CD40 triggering and plays important roles in sustaining the maturation of DCs and guiding the activation of T cells.
ICSBP-mediated immune protection against BCR-ABL–induced leukemia requires the CCL6 and CCL9 chemokines
Authors: Nardi Valentina , Naveiras Olaia , Azam Mohammad , Daley George Q. 
Published: January 2009

AbstractInterferon (IFN) is effective at inducing complete remissions in patients with chronic myelogenous leukemia (CML), and evidence supports an immune mechanism. Here we show that the type I IFNs (alpha and beta) regulate expression of the IFN consensus sequence-binding protein (ICSBP) in BCR-ABL–transformed cells and as shown previously for ICSBP, induce a vaccine-like immunoprotective effect in a murine model of BCR-ABL–induced leukemia. We identify the chemokines CCL6 and CCL9 as genes prominently induced by the type I IFNs and ICSBP, and demonstrate that these immunomodulators are required for the immunoprotective effect of ICSBP expression. Insights into the role of these chemokines in the antileukemic response of IFNs suggest new strategies for immunotherapy of CML.
Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia
Authors: Hollink Iris H. I. M. , van den Heuvel-Eibrink Marry M. , Zimmermann Martin , Balgobind Brian V. , Arentsen-Peters Susan T. C. J. M. , Alders Marielle , Willasch Andre , Kaspers Gertjan J. L. , Trka Jan , Baruchel Andre , de Graaf Siebold S. N. , Creutzig Ursula , Pieters Rob , Reinhardt Dirk , Zwaan C. Michel 
Published: January 2009

AbstractWilms tumor 1 (WT1) mutations have recently been identified in approximately 10% of adult acute myeloid leukemia (AML) with normal cytogenetics (CN-AML) and are associated with poor outcome. Using array-based comparative genome hybridization in pediatric CN-AML samples, we detected a WT1 deletion in one sample. The other WT1 allele was mutated. This prompted us to further investigate the role of WT1 aberrations in childhood AML. Mutations were found in 35 of 298 (12%) diagnostic pediatric AML samples. In 19 of 35 (54%) samples, more than one WT1 aberration was found: 15 samples had 2 different mutations, 2 had a homozygous mutation, and 2 had a mutation plus a WT1 deletion. WT1 mutations clustered significantly in the CN-AML subgroup (22%; P < .001) and were associated with FLT3/ITD (43 vs 17%; P < .001). WT1 mutations conferred an independent poor prognostic significance (WT1 mutated vs wild-type patients: 5-year probability of overall survival [pOS] 35% vs 66%, P = .002; probability of event-free survival 22% vs 46%, P < .001; and cumulative incidence of relapse or regression 70% vs 44%, P < .001). Patients with both a WT1 mutation and a FLT3/ITD had a dismal prognosis (5-year pOS 21%). WT1 mutations occur at a significant rate in childhood AML and are a novel independent poor prognostic marker.
Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome
Authors: Wouters Bas J. , Löwenberg Bob , Erpelinck-Verschueren Claudia A. J. , van Putten Wim L. J. , Valk Peter J. M. , Delwel Ruud 
Published: January 2009

Abstract
Mutations in CCAAT/enhancer binding protein α (CEBPA) are seen in 5% to 14% of acute myeloid leukemia (AML) and have been associated with a favorable clinical outcome. Most AMLs with CEBPA mutations simultaneously carry 2 mutations (CEBPAdouble-mut), usually biallelic, whereas single heterozygous mutations (CEBPAsingle-mut) are less frequently seen. Using denaturing high-performance liquid chromatography and nucleotide sequencing, we identified among a cohort of 598 newly diagnosed AMLs a subset of 41 CEBPA mutant cases (28 CEBPAdouble-mut and 13 CEBPAsingle-mut cases). CEBPAdouble-mut associated with a unique gene expression profile as well as favorable overall and event-free survival, retained in multivariable analysis that included cytogenetic risk, FLT3-ITD and NPM1 mutation, white blood cell count, and age. In contrast, CEBPAsingle-mut AMLs did not express a discriminating signature and could not be distinguished from wild-type cases as regards clinical outcome. These results demonstrate significant underlying heterogeneity within CEBPA mutation-positive AML with prognostic relevance.