bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanism of Molecular Recognition on Tetrapetide‐imprinted Monolith by Capillary Electrochromatography
Authors: ZHENG Chao , LIU Zhao‐Sheng , GAO Ru‐Yu , ZHANG Yu‐Kui 
Published: October 2008

Abstract A tetrapeptide‐imprinted capillary monolithic column was synthesized successfully in the presence of YPLG (Tyr‐Pro‐Leu‐Gly) as template by in situ thermo‐initiated polymerization. For exploring the recognition mechanism of molecularly imprinted polymer in a capillary electrochromatography (CEC) mode, YPLG and its structural analogue, YPGL (Tyr‐Pro‐Gly‐Leu), differing in amino acid sequence, were used as model compounds. It is hard work to separate the two tetrapeptides by a simple CEC or a capillary electrophoresis mode due to their similar chemical structures and values of pI. However, the results showed that YPLG could be recognized specially by the imprinted monolith. The separation factor (α ′) and the resolution (Rs) between YPLG and YPGL were 1.73 and 3.72, respectively. The effects of organic modifier concentration, pH value of buffer, salt concentration of buffer and column temperature on the recognition of YPLG and YPGL were investigated. A non‐linear Van′t Hoff behavior of the template was observed on a YPLG‐imprinted column, which suggested the presence of multiple types of retention mechanisms or multiple types of binding sites. The results showed that the molecular recognition on MIP monolith in the CEC mode mainly derived from hydrogen bonding between YPLG and MIP and three‐dimensional structure of the imprinting cavities.
Synthesis and Structural Studies of 1‐Deoxybaccatin VI Derivatives
Authors: LIN Hai‐Xia , WANG Dian‐Long , CHEN Jian‐Min , CHEN Min‐Qin 
Published: October 2008

AbstractSynthesis and crystal structures of 1‐deoxybaccatin VI derivatives, and the influence of C(9), C(10), and C(13) substituents of the tetracyclic moiety on molecular conformations were investigated. Comparison of conformations of 1‐deoxybaccatin VI derivatives reveals subtle conformational variations in the tetracyclic ring system due to deacetylation at C(10) and C(13), and 9,10‐acetonide. Additionally, C(2)‐benzoyl group exhibits an unexpected conformational flexibility in 1‐deoxybaccatin VI derivatives, which may be relevant to the bioactivity of taxanes.
Resonance Rayleigh Scattering Spectrum of Palladium(II)‐ Clindamycin‐Halofluorescein Systems and Their Analytical Applications
Authors: YI Ao‐Er , LIU Zhong‐Fang , LIU Shao‐Pu , KONG Ling 
Published: October 2008

AbstractIn pH 5.0–5.4 HOAc‐NaOAc buffer solution, clindamycin (Clin) could react with Pd(II) to form a 1:1 cationic chelate, which could further react with halofluorescein dyes such as diiodofluorescein (DIF), erythrosine (Ery) and eosin Y (EY) to form 1:1 ion‐association complexes. As a result, not only the absorption and fluorescence spectra were changed, but also the resonance Rayleigh scattering (RRS) intensities enhanced greatly and new RRS spectra appeared. The three reaction products had characteristic RRS spectra and their maximum RRS wavelengths were located at 285 (DIF system), 287 (Ery system) and 321 (EY system) nm, respectively. The scattering intensities were proportional to the concentration of Clin in certain range which could be applied to determine Clin. The linear ranges and detection limits of Clin were 0.025–2.1 µg·mL−1 and 7.8 ng·mL−1 for the DIF system, 0.053–2.4 µg·mL−1 and 16.0 ng·mL−1 for the Ery system, 0.038–2.4 µg·mL−1 and 11.0 ng·mL−1 for the EY system, respectively. In this work, the optimum reaction conditions and the foreign substances were investigated. A simple, sensitive and fast method was developed for the determination of Clin either in the pharmaceutical form or in the human body fluid. Moreover, the composition, structure, reaction mechanism of the ternary complexes and their effects on the absorption, fluorescence and RRS spectra as well as the reasons of RRS enhancement were discussed.
Preparation of Core‐shell Microspheres by ATRP Synthesized Macromonomer
Authors: CHU Hong , YANG Wei , CHEN Ming‐Qing , LU Jian‐Yan , SHI Dong‐Jian , AKASHI Mitusu 
Published: October 2008

Abstract Poly(tert‐butyl methacrylate) macrointermediates (PtBMA‐Br) with an end of bromine atom were synthesized by atom transfer radical polymerization using ethylbromopropionate as an initiator in bulk in the presence of N,N,N′,N′′,N′′‐pentamethyl diethylenetriamine (PMDETA) as a single ligand. A new macromonomer (MAA‐ PtBMA) was successfully prepared via end‐group nucleophilic substitution with methacrylic acid to attain a high efficiency of C=C incorporation. The molecular weights of MAA‐PtBMA macromonomers were controllable from 5400 to 11000 g/mol, and the molecular weight distribution was narrow (≤1.20). Then, the PtBMA graft polystyrene (PtBMA‐g‐PSt) microspheres were prepared by dispersion copolymerization of MAA‐PtBMA macromonomers with styrene using 2,2′‐azobisisobutyronitrile as a free radical initiator in ethanol. The resulting PtBMA‐g‐PSt microspheres were regulated in diameter on a micron scale.
Reversible Addition‐fragmentation Chain Transfer Polymerization Grafted from Silicon Surface to Prepare Poly(methyl methacrylate) Brushes
Authors: YUAN Kun , LÜ Ling‐Ling , LI Zhi‐Feng , SHI Xiao‐Ning 
Published: October 2008

AbstractPoly(methyl methacrylate) (PMMA) brushes grafted from silicon wafer surface were prepared using a reversible addition fragmentation chain transfer (RAFT) technique. 4‐Cyano‐4‐((thiobenzoyl)sulfanyl)pentanoic succinimide ester, a novel RAFT agent, was immobilized on the silicon wafer surface. RAFT polymerizations were then conducted from the silicon surface to polymerize from the silicon surface. Kinetic studies revealed that the thickness of the PMMA film increased almost linearly with the polymerization time after 2 h, indicating that the chain growth from the surface was a controlled process with a "living" character. The PMMA brushes were characterized using ellipsometry, X‐ray photoelectron spectra (XPS), atomic force microscopy (AFM) and contact angle measurements.
Enhanced Energy Conversion Efficiency of La3+‐Modified Nanoporous TiO2 Electrode Sensitized with a Ruthenium Complex
Authors: WU Xiao‐Hong , WANG Song , GUO Yun , XIE Zhao‐Yang , HAN Lu , JIANG Zhao‐Hua 
Published: October 2008

AbstractThe nature of TiO2 films and sensitizer play significant roles in determining the overall efficiency and mechanical stability of dye sensitized solar cell. In this study, cis‐RuL2(SCN)2, (L=2,2′‐dipyridine‐4,4′‐dicarboxlic acid) was synthesized from 4‐methylpyridine by the procedure of cross‐coupling, oxidation, conjugation and ligand substitution. TiO2 films were obtained by blending P25 and TiO2 sol. To increase the photoelectric properties of the thin TiO2 films, La(NO3)3 with different concentrations (0.1%, 0.3%, 0.5% and 0.7%) were added into the sol. Both undoped and doped samples of the thin films were sensitized by cis‐RuL2(SCN)2 and structurally characterized by X‐ray diffraction, atomic force microscopy and X‐ray photoelectron spectroscopy. In addition, the photoelectric properties of the TiO2 electrodes were investigated. The results show that doping lanthanum ions made the grain size smaller and surface area larger. When the concentration dopant is 0.5%, the short circuit current and open circuit voltage of the TiO2 film reach maximum. The short circuit current increases 0.54 mA/cm2 more than that of undoped film, and the open‐circuit voltage increases 30.41 mV more than that of undoped film.
Synthesis and Triethylamine‐catalyzed Cyclization Reaction of 4‐Pentyne‐1,3‐dione System Having Various Substituents
Authors: KURODA Hirofumi , IZAWA Hironori 
Published: October 2008

Abstract4‐Pentyne‐1,3‐dione system having various substituents was synthesized in two steps and the cyclization behavior of the obtained 1,3‐dicarbonyl compounds was examined. γ‐Pyrones and 2‐alkylidene‐2,3‐dihydro‐3‐furanones were obtained by the triethylamine‐catalyzed cyclization of the 4‐pentyne‐1,3‐dione system having a diketone moiety. Furthermore, a phenol derivative was obtained in the case of 4‐pentyne‐1,3‐dione system having an ester moiety. Thus, it was found that the kind of substituents in the 4‐pentyne‐1,3‐dione system remarkably influenced the selectivity in the cyclization.
Rates and predictors of chemotherapy use for stage III colon cancer
Authors: Etzioni David A. , El‐Khoueiry Anthony B. , Beart Robert W. 
Published: October 2008

AbstractDespite consensus regarding the benefits of chemotherapy for stage III colon cancer, multiple reports have found significant variations in rates of use. In the current study, the authors attempted to systematically review reports of the community rates at which chemotherapy is administered for stage III colon cancer in the US, and in so doing plan strategies for improving rates of use. A systematic search strategy was undertaken using MEDLINE, Web of Science, and bibliographies to find reports of the rates at which patients with stage III colon cancer receive chemotherapy. A total of 22 studies published since 1990 were identified, with rates of chemotherapy use ranging from 39% to 71%. Age and comorbidity were found to be the most significant patient factors, but studies also found racial/ethnic and socioeconomic disparities in the rates of chemotherapy. Patients treated at teaching hospitals did not clearly receive chemotherapy more often. Oncologists and surgeons who treat a higher volume of colorectal cancer patients were more likely to have chemotherapy initiated in their patients. The authors developed a conceptual model of the process pathway experienced by patients with stage III colon cancer to demonstrate areas of potential underuse of chemotherapy. Nearly half of patients with stage III chemotherapy in the US do not receive chemotherapy. Although many patients are too old or frail to benefit appropriately, for many patients chemotherapy is simply not initiated. Attention needs to be focused on systematic approaches to prevent systems failures that result in underuse. Guidelines regarding chemotherapy use in elderly patients are especially important. Cancer 2008. © 2008 American Cancer Society.
National Cancer Institute Patient Navigation Research Program
Authors: Freund Karen M. , Battaglia Tracy A. , Calhoun Elizabeth , Dudley Donald J. , Fiscella Kevin , Paskett Electra , Raich Peter C. , Roetzheim Richard G. ,   The Patient Navigation Research Program Group
Published: October 2008

AbstractBACKGROUND.Patient, provider, and systems barriers contribute to delays in cancer care, a lower quality of care, and poorer outcomes in vulnerable populations, including low‐income, underinsured, and racial/ethnic minority populations. Patient navigation is emerging as an intervention to address this problem, but navigation requires a clear definition and a rigorous testing of its effectiveness. Pilot programs have provided some evidence of benefit, but have been limited by evaluation of single‐site interventions and varying definitions of navigation. To overcome these limitations, a 9‐site National Cancer Institute Patient Navigation Research Program (PNRP) was initiated.METHODS.The PNRP is charged with designing, implementing, and evaluating a generalizable patient navigation program targeting vulnerable populations. Through a formal committee structure, the PNRP has developed a definition of patient navigation and metrics to assess the process and outcomes of patient navigation in diverse settings, compared with concurrent continuous control groups.RESULTS.The PNRP defines patient navigation as support and guidance offered to vulnerable persons with abnormal cancer screening or a cancer diagnosis, with the goal of overcoming barriers to timely, quality care. Primary outcomes of the PNRP are 1) time to diagnostic resolution; 2) time to initiation of cancer treatment; 3) patient satisfaction with care; and 4) cost effectiveness, for breast, cervical, colon/rectum, and/or prostate cancer.CONCLUSIONS.The metrics to assess the processes and outcomes of patient navigation have been developed for the NCI‐sponsored PNRP. If the metrics are found to be valid and reliable, they may prove useful to other investigators. Cancer 2008. © 2008 American Cancer Society.
Marital quality and survivorship
Authors: Yang Hae‐Chung , Schuler Tammy A. 
Published: October 2008

AbstractBACKGROUD:Although marital distress has been implicated in difficulties with adjustment to a breast cancer diagnosis, its long‐term effects, especially on physical recovery, are unknown.METHODS:Longitudinal data from newly diagnosed breast cancer patients (N = 100) who were married or cohabiting were used. Patients were assessed after diagnosis and surgery (baseline) and then reassessed every 4 or 6 months for the next 5 years. Women in stable, distressed relationships (n = 28) were compared with those in stable, nondistressed relationships (n = 72). Stress, health behavior, and health outcomes were examined using mixed‐effects modeling.RESULTS:Overall, marital distress was associated with slowed recovery trajectories and poor outcomes. At baseline, both groups had equivalent, high levels of stress, but diverged thereafter. Stress declined more slowly for the Distressed group, and by 5 years it remained significantly higher. Differential reductions in physical activity were also observed. With regard to health, the Distressed group was found to have a slower recovery in performance status and more symptoms/signs of illness and treatment side effects through 3 years. Finally, all the effects were observed above and beyond reductions occurring with depressive symptomatology, which was significantly higher in the Distressed group.CONCLUSIONS:Marital distress is not only associated with worse psychologic outcomes for breast cancer survivors, but poorer health and a steeper decline in physical activity. These novel data demonstrate recovery trajectories for breast cancer survivors to be constrained for those also coping with ongoing difficulties in their marriage. Cancer 2009. © 2008 American Cancer Society.
Maintenance factors for persistence of bulimic pathology: A prospective natural history study
Authors: Bohon Cara , Stice Eric , Burton Emily 
Published: October 2008

AbstractObjective:To characterize the natural course of bulimia nervosa and identify potential maintenance factors that predict persistence of bulimic pathology in order to advance knowledge of processes that perpetuate this eating disturbance and permit the design of more efficacious treatments.Method:We followed 96 women with threshold or subthreshold bulimia nervosa over a 1‐year period with quarterly interviews.Results:There were high rates of remission and relapse on a month‐to‐month basis, but remission became more likely to persist after a period of approximately 4 months of symptom abstinence. Initial elevations in thin‐ideal internalization, expectations for reward from eating, and binge frequency predicted greater time to remission of binge eating. Initial elevations in dietary restraint and compensatory behavior frequency predicted greater time to remission of compensatory behaviors.Discussion:Results imply that treatments for eating disorder may be more effective if they can reduce thin‐ideal internalization, eating expectancies, and ineffective dieting and produce rapid cessation of binge eating and compensatory behaviors. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2009
Affective lability and impulsivity in a clinical sample of women with bulimia nervosa: The role of affect in severely dysregulated behavior
Authors: Anestis Michael D. , Peterson Carol B. , Bardone‐Cone Anna M. , Klein Marjorie H. , Mitchell James E. , Crosby Ross D. , Wonderlich Stephen A. , Crow Scott J. , le Grange Daniel , Joiner Thomas E. 
Published: October 2008

AbstractObjective:The primary aim of this study was to examine the role of affective lability in maladaptive behaviors in a sample of women who meet DSM criteria for current bulimia nervosa (BN).Method:Participants were administered a semistructured diagnostic interview (SCID‐P) and only those who currently met criteria for BN (N = 134) were included in the analyses. All other data were collected through the use of self‐report questionnaires.Results:Affective lability significantly predicted the Impulsive Behavior Scale score (sr = 0.21, t = 2.64, p < .009, f2 = 0.06) and excessive reassurance seeking (sr = 0.21, t = 2.74, p < .007, f2 = 0.06), even when controlling for age, depressive symptoms, state and trait anxiety, and general impulsivity.Discussion:The degree to which individuals with BN experience labile emotions is associated with several indicators of dysregulated behavior such that higher levels of affective lability predict a more severely dysregulated behavioral profile. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2009
Preparation, Electrochemistry, and Electrocatalytic Activity of Lead Pentacyanonitrosylferrate Film Immobilized on Carbon Ceramic Electrode
Authors: Razmi H. , Heidari H. 
Published: October 2008

AbstractLead pentacyanonitrosylferrate (PbPCNF), a new Prussian blue analog, was immobilized on the surface of a carbon ceramic electrode (CCE) prepared by sol‐gel method. The immobilization process consists of adding a certain amount of metallic lead to the electrode matrix before gelation, and chemical derivatization of Pb on the electrode surface to a PbPCNF solid film by immersing the electrode in a solution of sodium pentacyanonitrosylferrate (PCNF). The composition of the synthesized PbPCNF was characterized by FTIR, scanning electron microscopy (SEM), and energy‐dispersive X‐ray (EDX) techniques. The resulting modified electrode showed electroactivity at two redox centers. The electrochemical behavior of the PbPCNF modified carbon ceramic electrode (PbPCNF|CCE) was studied by cyclic voltammetry. Under optimized conditions the peak‐to‐peak separation is only 39 mV, indicative of a surface reaction. Ion effects of the supporting electrolyte suggest that cations have a considerable effect on the electrochemical behavior of the modified electrode. The transfer coefficient (α) and the charge transfer rate constant at the modifying film|electrode interface (ks) were calculated. The electrocatalytic activity of the modified electrode toward the electro‐reduction of peroxodisulfate was studied in details.
Aptasensor for Thrombin Based on Carbon Nanotubes‐Methylene Blue Composites
Authors: Evtugyn Gennady , Porfireva Anna , Ryabova Maria , Hianik Tibor 
Published: October 2008

AbstractThe amperometric and EQCM aptasensors based on DNA aptamers immobilized by avidin‐biotin method or by electrostatic adsorption onto multiwalled carbon nanotube layer contained methylene blue (MB) have been developed and examined for thrombin detection in buffer and in spiked blood serum. The presence of MB increases the binding capacity of the surface layer and enhances the range of thrombin concentrations to be determined. This results in significant improvement of analytical characteristics of thrombin detection. The EQCM aptasensors allowed us to detect 0.3–100 nM and amperometric aptasensors 10–1000 nM of thrombin.
Annual miles drive used car prices
Authors: Engers Maxim , Hartmann Monica , Stern Steven 
Published: October 2008

AbstractThis paper investigates whether the net benefits from owning a vehicle, proxied by annual miles driven, explain the price declines observed over a vehicle's life. We first model the household decision on how much to drive each of its vehicles. Then we empirically establish that variation in household annual miles across brands explains observed price declines. Furthermore, the effect of vehicle age on annual miles decisions (and consequently on market value) depends on household characteristics and the composition of the vehicle stock owned. Copyright © 2008 John Wiley & Sons, Ltd.
Batch cooling crystallization of xylitol produced by biotechnological route
Authors: Martínez Ernesto Acosta , Giulietti Marco , Almeida e Silva João Batista de , Derenzo Silas , Almeida Felipe Maria das Graças 
Published: October 2008

AbstractBACKGROUND: This work deals with the xylitol production by biotechnological routes emphasizing the purification process using crystallization.RESULTS: Xylitol volumetric productivity of 0.665 g L−1 h−1 and yield of 0.7024 g g−1 were obtained after 92 h fermentation. The fermented broth (61.3 g L−1 xylitol) was centrifuged, treated and concentrated obtain a syrup (745.3 g L−1 xylitol) which was crystallized twice, xylitol crystals with 98.5–99.2% purity being obtained.CONCLUSION: The hypothetical distribution obtained permits the determination of modeling parameters, which make possible the estimation of crystal dominant size from different initial experimental conditions. Copyright © 2008 Society of Chemical Industry
Expression of brain‐type fatty acid‐binding protein (fabp7) in medaka during development
Authors: Maruyama Kouichi , Kojima Ayako , Yasuda Takako , Suetomi Katsutoshi , Kubota Yoshihisa , Takahashi Sentaro , Ishikawa Yuji , Fujimori Akira 
Published: October 2008

AbstractFatty acid‐binding proteins (FABPs) belong to a multigene family of small intracellular proteins that bind hydrophobic ligands. Recent studies have indicated that FABP7 plays important roles in neurogenesis or neuronal migration in vertebrates. In this study, we isolated cDNA and the genomic fragment containing the fabp7 gene for medaka fish and examined the expression of the medaka fabp7 gene through the development of their central nervous system (CNS). The medaka fabp7 gene consists of four exons in approximately 1 kb of the genomic region. Its deduced amino acid sequence exhibits over 80% identity with those of other higher vertebrates. In situ hybridization analysis demonstrated that fabp7‐positive cells first appear at stage 22 in a small dorsal domain of the retina, dorsal diencephalon, and rhombencephalon, then expand to the entire CNS including the retina and the spinal cord. In addition, we generated two lines of transgenic medaka with 1.7 kb upstream of the fabp7 gene combined with the enhanced‐green fluorescence protein (EGFP) gene. The spatio‐temporal expression patterns of EGFP in these animals were consistent with the results of in situ hybridization analysis. The result of our reporter assays with a series of truncated fabp7 promoters suggested that POU elements play a role in fabp7 expression in medaka as well as in other vertebrates. Our transgenic animal will contribute to clarifying the role of FABP7 in the development of CNS. J. Exp. Zool. (Mol. Dev. Evol.) 310B:577–587, 2008. © 2008 Wiley‐Liss, Inc.