bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wound healing in sarcoma‐bearing rats: Tumor effects on cutaneous and deep wounds
Authors: Lawrence W. Thomas , Norton Jeffrey A. , Harvey Anita K. , Gorschboth Catherine M. , Talbot Thomas L. , Grotendorst Gary R. 
Published: February 2007

AbstractMany surgeons think that cancer causes a higher incidence of wound complications. Wound healing was examined in a cutaneous and deep model in control and sarcoma‐bearing rats to evaluate this concept. In a dorsal incisional wound, a significant decrease in wound breaking strength was observed from 19 days after tumor implantation onward. The amount of the breaking strength deficit increased with the size of tumor and the day post‐tumor implant. In a deeper wound chamber, hydroxyproline levels, 3H‐thymidine incorporation into DNA, histology, and collagen types were examined, and tumor produced no significant change in any parameter. The presence of tumor appeared to inhibit wound healing in cutaneous wounds but had no apparent effect on deeper wounds. This difference in healing in the two wound models is important to surgical oncologists. Because there is no demonstrable tumor‐induced healing deficit in deep wounds, cancer‐bearing organisms probably still heal these wounds normally.
Mastectomies for malignancy: A DRG‐based hospital utilization analysis
Authors: Bredenberg Patricia A. , Lagoe Ronald J. 
Published: February 2007

AbstractThe study identified hospital utilization patterns by diagnosis‐related group (DRG) produced by mastectomies for malignancy in Sacramento, California, and Syracuse, New York, for the years 1981‐1984. A total of 3,449 discharges were included. Total and subtotal mastectomy discharges per capita increased in both areas. The proportion of mastectomy discharges attributed to total mastectomies increased in Sacramento and decreased in Syracuse. Mean stays for mastectomy DRGs declined by 13.72 to 56.38%. In 1984 mean stays ranged from 4.79 to 7.49 days for total mastectomies and 1.88 to 5.44 days for subtotal mastectomies. A major problem identified by the study was the lack of DRG sensitivity to differences in types of procedures. Under DRGs, radical and simple mastectomies are combined in one type of cateogry, while subtotal mastectomies, quadrant resections, and breast biopsies are combined in another.
Epidemiology and clinical characteristics of testicular tumors in Saudi Arabia: King Faisal specialist hospital and research centre experience
Authors: El‐Senoussi Mohamed A. , Bissada Nabil K. , El‐Akkad Salah , Bedikian Agop Y. , Morcos Rafik , Bull Colin 
Published: February 2007

AbstractThe data on 62 patients with germinal testicular tumors seen at King Faisal Specialist Hospital and Research Centre between January 1977 and June 1983 were analyzed to determine the epidemiologic and clinical characteristics of the disease in Saudi Arabia. Fifty‐seven patients were Saudis. The geographic distribution of Saudi patients seemed to coincide with population concentrations. Testicular seminomas (TS) and non‐seminomatous testicular tumors (NSTT) comprised 50% each. The mean age was 41 and 27.8 years for TS and NSTT, respectively. Fifteen patients had cryptorchidism of the involved testicle. Three patients with NSTT had a history of trauma to the involved testicle. The most common presentations were painless testicular swelling (51.6%), painful swelling (16%), and abdominal or inguinal swelling (21%). The delay between the onset of symptoms and referral (mean 15 months) was considerable. Eighty percent of patients with NSTT and 45 % of those with TS had advanced disease at referral.
Pediatric infiltrating lipomas: Case report and review of the literature
Authors: Winkler Martin , Petrelli Nicholas , Cohen Arthur 
Published: February 2007

AbstractA case of pediatric infiltrating lipoma and a collected literature review of four pediatric patients with well‐documented infiltrating lipomas are presented. These lesions tend to recur after resection but there are no reported incidences of distant metastases or degeneration into frankly malignant lesions. Treatment consists of excising the lesion with a margin of normal muscle.
Localized deep hyperthermia increases the traffic of lymphocytes through peripheral lymph nodes of sheep in vivo
Authors: Moore Thomas C. , Nur Khalid , Storm F. Kristian 
Published: February 2007

AbstractThe production of localized deep hyperthermia by the radio frequency wave magnetic‐loop induction method has been utilized to study the effects of deep hyperthermia on lymphocyte traffic in sheep in vivo. Deep hyperthermia has been applied both to primary peripheral lymph node drainage areas alone (popliteal and prefemoral) and directly over the study lymph node (popliteal). Deep tissue core temperatures were monitored in all studies and the findings were correlated with alterations in the levels of lymphocyte outputs into study node efferent lymph and the volume of efferent lymph flow. In all of 32 studies, there was a prompt and sharp increase in the output of lymphocytes into efferent lymph at 40‐43 °C. Efferent lymph flow also was increased promptly but to a lesser degree than the output of lymphocytes. The two were not closely correlated. High deep temperature in the nodal area (45 °C) appeared to cause delayed nodal malfunction, which depressed lymphocyte output but did not affect lymph flow. Localized deep hyperthermia is an effective and noninvasive means for the local increase of lymphocyte traffic and lymph flow and may prove to be a useful means for the evaluation of the immunological consequences of altering both deep tissue temperature and lymphocyte traffic.
Anesthesia for intraoperative radiation therapy in children
Authors: Friesen Robert H. , Morrison John E. , Verbrugge Joseph J. , Daniel William E. , Aarestad Norman O. , Burrington John D. 
Published: February 2007

AbstractIntraoperative radiation therapy (IORT) is a relatively new mode of cancer treatment which is being used with increasing frequency. IORT presents several challenges to the anesthesiologist, including (1) patients who are debilitated from their disease or chemotherapy, (2) operations involving major tumor resections, (3) intraoperative interdepartmental transport of patients, and (4) remote monitoring of patients during electron beam therapy. This report discusses the anesthetic management of ten children undergoing IORT. With adequate preparation and interdepartmental communication, complications can be avoided during these challenging cases.
Hepatic adenoma within a spindle cell carcinoma in a woman with a long history of oral contraceptives
Authors: Grigsby P. , Meyer J. S. , Sicard G. A. , Huggins M. B. , Lamar D. J. , Deschryver‐Kecskemeti K. 
Published: February 2007

AbstractThe case of a young woman is presented who had a long history of oral contraceptive use and who was found to have a focal hepatic adenoma within a large spindle cell carcinoma of the liver. The pleomorphic tumor is positive for keratin and α1‐antitrypsin by immunohistochemistry, has intracellular lumina by electron microscopy, a moderately high thymidine labeling index, and is negative for estrogen and progesterone receptors. A review of the literature concerning liver tumors occurring in young patients indicates that there is an underlying disturbance of the hormonal milieu in all instances reported. The prognosis is widely variable and unpredictable.
Conservative surgery in zollinger‐ellison syndrome: Report of a case with an eight‐year follow‐up
Authors: Michowitz M. , Lazebnik N. , Noy S. , Baratz M. 
Published: February 2007

AbstractThe patient described here, with malignant non‐beta islet cell tumor of the head of the pancreas, was treated by resection of the tumor and metastases. Additional pathology of perforated duodenal ulcer and pyloric stenosis required vagotomy and pyloroplasty. The maintenance of normal gastrin levels after the operation indicates a good prognosis. We believe that the low‐risk Zollinger‐Ellison patient should be treated surgically and the tumor removed. When no tumor can be detected, parietal cell vagotomy should be performed to assist the pharmacological control of the gastric acid hypersecretion. Extensive surgery, such as total gastrectomy, is no longer the treatment of choice and is reserved for the so‐called “Cimetidine failure.”
Sequential elaboration of lymphocyte‐enhancing and ‐suppressing factors in the sera of tumor‐bearing animals
Authors: Wile Alan G. , Cohen Robert A. , Terem Theresa M. , Contino Michael F. , Kar Rita 
Published: February 2007

AbstractSerum‐mediated impairment of lymphocyte function was studied in an animal model. Sprague‐Dawley rats inoculated intraperitoneally or subcutaneously with the Walker 256 carcinoma underwent sequential sampling of blood. The effect of these serum samples upon phytohemagglutinin‐induced blastogenesis of normal rat splenocytes was monitored in an assay utilizing incorporation of (3H)‐thymidine. The effect of serum samples from both the subcutaneously and the intraperitoneally inoculated tumor‐bearing animals was biphasic. Early on, serum enhanced blastogenesis and later suppressed blastogenesis. Separation of sera into high and low molecular weight components by ultrafiltration demonstrated the enhancing activity to reside in the high molecular weight fraction. The enhancing activity of sera decreased over time from tumor inoculation. Conversely, suppressor activity increased over time from tumor inoculation. This study demonstrated that suppressor activity of sera obtained from animals with advanced tumors is the result of the lack of enhancing activity coupled with the elaboration of suppressor activity.
Primary liver cancer in a referral hospital in Hawaii
Authors: Geer Deborah A. , Lee Yeu‐Tsu Margaret , Brooks Viola P. , Berenberg Jeffery L. 
Published: February 2007

AbstractThis is a retrospective review of 43 patients who had primary liver cancer diagnosed during 1974‐1983. Patients' ages ranged from 27 to 84 years (median 52.5). Nine of 39 patients with hepatoma were females, while two of the four patients with cholangiocarcinoma were women. Hepatitis surface antigen was positive in 90% tested, and 62% had cirrhosis. Also, 60‐65% were heavy users of alcohol and cigarettes. Alpha‐fetoprotein was elevated in one of four white patients, and in six of eight patients of other races (75%). Tissue diagnosis was obtained by peritoneoscopy in 16, by percutaneous biopsy in 7, by laparotomy in 9, and at autopsy in 11. Only one of 11 patients who were explored has his lesion resected. About half of the cases diagnosed antemortem died 1 month or less after diagnosis. The median survival of hepatoma patients who had no specific treatment or systemic chemotherapy was 2 months. Two patients who received chemotherapy in conjunction with occlusion of the hepatic artery lived 16 to 19 months.
Right and left colon carcinoma: A retrospective comparative study
Authors: Kashtan Hanoch , Werbin Nahum , Aladjem David , Barak Yoram , Wiznitzer Theodore 
Published: February 2007

AbstractWe studied 347 patients with primary colorectal carcinoma treated by surgery during 1973‐1983: 64 (18.2%) with right colon carcinoma, 158 (45.7%) with left colon carcinoma, 14 (4.2%) with transverse colon carcinoma, and 110 (31.9%) with rectal carcinoma. We compared the right‐sided carcinoma (RSC) and left‐sided carcinoma (LSC) groups. Obstruction was found in 17.2% of RSC compared with 20.3% LSC patients (P > 0.05). Advanced disease (Dukes stages C and D) was found in 34.4% on the right and 47.8% on the left side (P = 0.01). Crude 5‐year survival rate, by life table method, was 71% on the right and 66% on the left side (P > 0.05); this difference became significant (P = 0.03) when Dukes stage B patients were compared. We conclude that patients with RSC are not diagnosed, as is commonly believed, at advanced stages of the disease. We found that the 5‐year survival rate of RSC patients was the same or, occasionally, better than that of LSC patients.
Needle aspiration cytologic diagnosis of metastatic malignant melanoma of unknown primary origin: Report of a case and review of the literature
Authors: Eftichiadou Chariclea , Vartholomeos Anastasios , Salem Nicolaos , Destouni Evangelia , Apostolidis P. 
Published: February 2007

AbstractA rare case of metastatic malignant melanoma of unknown primary origin in a 49‐year‐old woman is reported. The swelling, localized in the right inguinal region, was partially immovable and associated with propgressively increasing pain. Initial diagnosis was set by needle aspiration cytology and was confirmed postoperatively by histologic examination of a surgical specimen. Cytomorphologic features of metastatic malignant melanomas are described and the difficulties of identification discussed. A brief review of the literature is also made, and the rarity of the case and the value of cytologic diagnosis are emphasized.
Short‐term prophylaxis with cefuroxime in colorectal surgery for cancer
Authors: Colizza S. , De Fazio S. , Addari A. , Grande R. , Cucchiara G. 
Published: February 2007

AbstractA controlled study of short‐term prophylaxis with cefuroxime was performed on a group of 52 patients with colorectal neoplasms who underwent elective surgery. The patients were divided into two groups, A and B. Group A received the antibiotic immediately before surgery, intraincisionally and immediately after the end of operation; group B was treated only postoperatively. Each patient received a total of 5,250 mg of cefuroxime. Wound sepsis was demonstrated in 11.5% of cases of group A and 23.0% of group B (P < 0.01); another type of sepsis was observed in 34% of group A and 11.5% of group B (P < 0.001). There was no difference in the operative mortality in the two groups.
Somatostatinoma: A case report and review of the literature
Authors: Harris Gary J. , Tio Fermin , Cruz Anatolio B. 
Published: February 2007

AbstractSomatostatinomas are rare endocrine tumors that were first described in 1977. In addition to the present case report, there have been 31 cases reported in the literature. We have reviewed the literature to integrate the symptoms, physical findings, diagnostic tests, treatment, and length of survival of these patients. Although the symptoms that occurred in the majority of cases were those that are seen in most patients with intra‐abdominal neoplasms, symptoms relating to the presence of excess circulating somatostatin—diabetes, maldigestion, and cholelithiasis—were frequently seen. Physical findings and the results of diagnostic tests were usually nonspecific. The majority of the patients underwent radical surgical procedures (Whipple procedure or pancreatic resection). The pancreas was the most frequent site of involvement (21/31 cases), but primaries in the duodenum, ampulla of Vater, cystic duct, and jejunum have been described as well. Metastases were most frequently seen in the liver and lymph nodes. Chemotherapeutic agents were administered to 10 patients, usually as adjuvant therapy, and appear to be useful in treating recurrent and metastatic disease. The one‐year survival of these patients is 48%, which is better than that for patients with carcinoma of the pancreas or biliary tree. Therefore, it is important that the diagnosis of somatostinoma be made so that the patient may be treated accordingly and followed by serial somatostatin levels for evidence of metastasis or recurrent disease.
Intraoperative interstitial hyperthermia in conjunction with intraoperative radiation therapy in a radiation‐resistant carcinoma of the abdomen: Report on the feasibility of a new technique
Authors: Merrick Hollis W. , Milligan Andrew J. , Woldenberg Lee S. , Ahuja Rajender K. , Dobelbower Ralph R. 
Published: February 2007

AbstractThe application of a new technique of intraoperative interstitial hyperthermia (IOHT) and intraoperative radiation therapy (IORT) was investigated for unresectable abdominal carcinoma. A 43‐year‐old white male presented with severe back pain due to metastatic adenocarcinoma in the left paravertebral area, producing erosion of the body of T12. The disease had not responded to external beam radiation therapy. The tumor was approached through a thoraco‐abdominal incision and IOHT was delivered via interstitial electrodes. Temperature was monitored at 16 locations within the tumor. An LCF hyperthermia unit was utilized to deliver RF power and produced a treatment temperature of 43°C for 60 minutes uniformly throughout the treatment volume. Immediately following hyperthermia treatment, the lesion was treated with 15 meV electrons via IORT to a tumor dose of 25Gy. The patient recovered without complication and had complete relief from pain. Posttreatment CT scans have demonstrated control of disease over a 5‐month follow‐up period. A clinical pilot study has been established to further investigate the application of this combination therapy.
Benign mixed tumor (pleomorphic adenoma) of the breast: Ultrastructural study and review of the literature
Authors: Cuadros C. Luis , Ryan Stephen S. , Miller Robert E. 
Published: February 2007

AbstractA patient is presented with a benign mixed tumor (pleomorphic adenoma) of the breast. There are 11 well‐documented cases of this rare breast neoplasm. It is histologically and ultrastructurally identical to that seen in the salivary gland and follows a similar benign course. A central role of the ductal myoepithelial cell is proposed for the histogenesis of this tumor.
Survival of operated bronchus carcinoma patients: A prospective study
Authors: Kayser K. W. , Bülzebruck H. , Merkle N. , Vogt‐Moykopf I. 
Published: February 2007

AbstractMaximum diameter, tumour volume, and inflammatory response of host tissue in 282 surgical specimens with primary carcinoma of the bronchus were measured. Cell type, pT‐ and pN‐stage, maximum diameter and volume of the primaries, and inflammatory response of host tissue were analyzed in respect to survival of the patients. Date of death was evaluated by quarterly communications with the house physicians. Survival rates were computed by use of Kaplan‐Meier estimation. Mean survival of all patients was calculated at 480 days. Lymph node involvement and tumour volume were found to have a major influence on survival. In accordance with the weak contribution of maximum diameter of the tumour to survival, no major differences in survival between pT1‐ and pT2‐stage were found. If severe inflammatory response at the tumour boundary was noted, patients showed slightly increased survival in all tumour stages. Cell type and tumour grading were found to be of minor influence in respect to survival.
Two‐stage operation for poor‐risk patients with carcinoma of the esophagus
Authors: Sugimachi Keizo , Kitamura Masayuki , Maekawa Sohichiro , Matsufuji Hidemasa , Kai Hidenobu , Okudaira Yasuyuki 
Published: February 2007

AbstractWe have devised a two‐stage operation for poor‐risk patients with carcinoma of the thoracic esophagus. The first‐stage operation consists of a right thoracotomy, subtotal esophagectomy, and lymph node dissection. Two to three weeks later, the second‐stage operation of esophageal reconstruction with gastric tube is performed under laparotomy. During this 3‐week period of no esophagus, the nutritional status can be adequately maintained by intravenous hyperalimentation. We describe herein the technique, postoperative complications, and mortality of our two‐stage operation as compared with events during an ordinary one‐stage operation for carcinoma of the thoracic esophagus.
Primary adenocarcinoma of the appendix: Report of five cases and review of the literature
Authors: Ben‐Aaron U. , Shperber J. , Halevy A. , Negri M. , Bogokovski H. , Orda R. 
Published: February 2007

AbstractFive patients with primary adenocarcinoma of the appendix are reported. All patients presented with symptoms resembling those of acute appendicitis or periappendicular abscess. In none of them was malignancy suspected prior to operation. It is advisable that every patient above 50 years of age presenting with symptoms of appendicitis undergo laparotomy, thus enabling a better exploration of the cecal region. If an appendiceal mass is present and frozen section shows malignancy, a right hemicolectomy should be performed. The prognosis of adenocarcinoma of the appendix is dismal as most patients present with an advanced stage of the disease.
Management of endoscopically removed malignant colon polyps
Authors: Conte Charles C. , Welch John P. , Tennant Robert , Forouhar Faripour , Lundy Joel , Bloom G. Peter 
Published: February 2007

AbstractThe medical records of 87 patients with 89 malignant colorectal polyps removed endoscopically between 1971 and 1983 were reviewed retrospectively. Fifty‐five polyps contained carcinoma‐in‐situ. Four polyps had “pseudo‐invasion” by displaced mucosal glands. Thirty polyps contained invasive carcinoma. No patients with carcinoma‐in‐situ or “pseudo‐invasion” had either local residual disease or metastatic disease at the time of colectomy or which was detected during subsequent follow‐up. Four patients (14%) with invasive cancer would have been inadequately treated by polypectomy alone, since one had residual disease at the polypectomy site, one had nodal metastases, one had liver metastases at the time of colectomy, and one subsequently developed liver metastases. Three histologic criteria correctly predicted all four cases where residual or recurrent disease was present: involvement of the polypectomy resection margin, lymphatic invasion within the polyp, and poorly differentiated histology. Polyp size, histology (villous adenoma, adenomatous polyp, or villo‐adenomatous polyp), or anatomic location did not identify those patients who warranted further therapy. We conclude that polypectomy alone is adequate treatment for polyps containing carcinoma‐in‐situ. Polypectomy alone is also adequate treatment for most polyps containing invasive carcinoma. However, patients with lymphatic involvement within the polyp, poorly differentiated cancer, or resection margin involvement should probably undergo colectomy.
Mucoepidermoid carcinoma arising from a preexisting cyst of the liver
Authors: Hayashi Itsuro , Tomoda Hirotsugu , Tanimoto Masanori , Furusawa Motonosuke , Katsuda Yasaburo , Shirai Shigeo , Morimatsu Minoru 
Published: February 2007

AbstractA case of mucoepidermoid carcinoma of the liver of a 46‐year‐old female is described. The resected mass from the left lobe of the liver measured 3 × 3 × 2 cm. The cut surface showed a well demarcated white, round shape, and a cystic formation measuring 1.8 × 1.4 cm was present in the center of the mass. Microscopically, the mass showed high‐grade‐type mucoepidermoid carcinoma, which consisted of squamous cells, mucus‐producing cells, and glandular cells. The cystic wall was lined with apparently benign glandular, mucus‐producing cells, squamous metaplastic cells, and tumor cells. The tumor was intimately contiguous with the cyst and gradual transition between tumor cells and cystic lining cells was recognized. It is suggested that the mucoepidermoid carcinoma of the liver in the present case was derived from malignant transformation of a preexisting cyst of the liver.
Epithelial ovarian tumor in a phenotypic male
Authors: Monge Odd R. , Wiig Johan N , Halvorsen Tore B. , Jorgensen Ole G. , Kjorstad Kjell , Brogger Anton W. 
Published: February 2007

AbstractLaparotomy in a 41‐year‐old married man with non‐treated left cryptorchidism revealed female internal genitals on the left side, and an epithelial ovarian tumor of intermediate malignancy. Germinal malignancies are frequent in intersexes, but non‐germinal gonadal neoplasms are rare. This is the second reported case of epithelial ovarian tumor in intersexes, and the first case of epithelial ovarian tumor in an intersex registered as made.