bluuebunny/crossref_metadata_2025_split huggingface dataset:
Causal Interactions between Phase- and Amplitude-Coupling in Cortical Networks
Authors: Galindo-Leon Edgar E. , Nolte Guido , Pieper Florian , Engler Gerhard , Engel Andreas K. 
Published: March 2024

AbstractPhase coherence and amplitude correlations across brain regions are two main mechanisms of connectivity that govern brain dynamics at multiple scales. However, despite the increasing evidence that associates these mechanisms with brain functions and cognitive processes, the relationship between these different coupling modes is not well understood. Here, we study the causal relation between both types of functional coupling across multiple cortical areas. While most of the studies adopt a definition based on pairs of electrodes or regions of interest, we here employ a multichannel approach that provides us with a time-resolved definition of phase and amplitude coupling parameters. Using data recorded with a multichannel µECoG array from the ferret brain, we found that the transmission of information between both modes can be unidirectional or bidirectional, depending on the frequency band of the underlying signal. These results were reproduced in magnetoencephalography (MEG) data recorded during resting from the human brain. We show that this transmission of information occurs in a model of coupled oscillators and may represent a generic feature of a dynamical system. Together, our findings open the possibility of a general mechanism that may govern multi-scale interactions in brain dynamics.
The bidirectional role of GABAAand GABABreceptors during the differentiation process of neural precursor cells of the subventricular zone
Authors: Gutierrez-Castañeda Estefanía , Martínez-Rojas Vladimir Alex , Ochoa-de la Paz Lenin David , Galván Emilio J. 
Published: March 2024

AbstractThe intricate process of neuronal differentiation integrates multiple signals to induce transcriptional, morphological, and electrophysiological changes that reshape the properties of neural precursor cells during their maturation and migration process. An increasing number of neurotransmitters and biomolecules have been identified that serve as molecular signals that trigger and guide this process. In this sense, taurine, a sulfur-containing, non-essential amino acid widely expressed in the mammal brain, modulates the neuronal differentiation process. In this study, we describe the effect of taurine acting via the ionotropic GABAAreceptor and the metabotropic GABABreceptor on the neuronal differentiation and electrophysiological properties of precursor cells derived from the subventricular zone of the mouse brain. Taurine stimulates the number of neurites and favors the dendritic complexity of the neural precursor cells, accompanied by changes in the somatic input resistance and the strength of inward and outward membranal currents. At the pharmacological level, the blockade of GABAAreceptors inhibits these effects, whereas the stimulation of GABABreceptors has no positive effects on the taurine-mediated differentiation process. Strikingly, the blockade of the GABABreceptor with CGP533737 stimulates neurite outgrowth, dendritic complexity, and membranal current kinetics of neural precursor cells. The effects of taurine on the differentiation process involve Ca2+mobilization and the activation of intracellular signaling cascades since chelation of intracellular calcium with BAPTA-AM, and inhibition of the CaMKII, ERK1/2, and Src kinase inhibits the neurite outgrowth of neural precursor cells of the subventricular zone.
Rapid Instructed Task Learning is impaired after stroke and associated with impairments in prepotent inhibition and processing speed
Authors: Binyamin-Netser Reut , Shkedy-Rabani Anat , Shmuelof Lior 
Published: March 2024

AbstractBackgroundMotor rehabilitation is a central contributor to motor recovery after stroke. This process could be hampered by stroke-associated cognitive impairments, such as the capability to rapidly follow instructions (Rapid instructed task learning, RITL). RITL was never directly studied in old adults and subjects with stroke. The aim of this study was to assess RITL following stroke and its underlying cognitive determinants.Methods31 subjects with chronic stroke and 36 age-matched controls completed a computerized cognitive examination that included an anti-saccade task for measuring prepotent inhibition and processing speed and stimulus-response association task (NEXT) for measuring RITL and proactive inhibition.ResultsRITL abilities were impaired after stroke, together with prepotent inhibition and processing speed. A correlation analysis revealed that RITL is associated with prepotent inhibition abilities and with processing speed.ConclusionsSubjects with stroke show impairments in the ability to follow instructions, that may be related to their impaired prepotent inhibition and processing speed. The causal effect of RITL impairments on the responsivity to rehabilitation and on motor recovery should be examined.
Exploring cross-cultural disparities in tourists' perceived images: a text mining and sentiment analysis study using LDA and BERT-BILSTM models
Authors: Chen Qiuying , Liu Ronghui , Jiang Qingquan , Xu Shangyue 
Published: March 2024

PurposeTourists with different cultural backgrounds think and behave differently. Accurately capturing and correctly understanding cultural differences will help tourist destinations in product/service planning, marketing communication and attracting and retaining tourists. This research employs Hofstede's cultural dimensions theory to analyse the variations in destination image perceptions of Chinese-speaking and English-speaking tourists to Xiamen, a prominent tourist attraction in China.Design/methodology/approachThe evaluation utilizes a two-stage approach, incorporating LDA and BERT-BILSTM models. By leveraging text mining, sentiment analysis and t-tests, this research investigates the variations in tourists' perceptions of Xiamen across different cultures.FindingsThe results reveal that cultural disparities significantly impact tourists' perceived image of Xiamen, particularly regarding their preferences for renowned tourist destinations and the factors influencing their travel experience.Originality/valueThis research pioneers applying natural language processing methods and machine learning techniques to affirm the substantial differences in the perceptions of tourist destinations among Chinese-speaking and English-speaking tourists based on Hofstede's cultural theory. The findings furnish theoretical insights for destination marketing organizations to target diverse cultural tourists through precise marketing strategies and illuminate the practical application of Hofstede's cultural theory in tourism and hospitality.
The impact of message framing on perceptions of controversial CSR in hotels
Authors: Belarmino Amanda , Whalen Elizabeth A. , Guzzo Renata Fernandes 
Published: March 2024

PurposeThe purpose of this paper is to understand how hospitality companies can best explain controversial corporate social responsibility (CSR) activities to consumers who may not agree with the CSR activity. This research explores message framing through emotional and cognitive appeals to influence consumer perceptions of the Gideon Bible in USA hotel rooms. The study uses the theory of deontic justice to measure the impacts of messaging on consumer perceptions of the morality of the Gideon Bible as suicide prevention in hotels and its relation to controversial CSR initiatives.Design/methodology/approachThe study uses an experimental study design via a self-administered survey to analyze participants’ perceptions of the placement of the Gideon Bible in hotel rooms and participants’ attitudes toward CSR initiatives based on deontic justice and religion using different message framing conditions.FindingsResults show that religion was a major determinant of attitude towards the Gideon Bible, but the sentiment analysis also revealed that negative perceptions can be mitigated through message framing via emotional and cognitive appeals. Additionally, the cognitive appeal did impact CSR perceptions, as did identifying as Christian. Moral outrage emerged as a significant moderator for the relationships between message framing, attitudes toward the Gideon Bible and CSR.Originality/valueThis study provides an extension of deontic justice research to examine justice traits in accepting controversial CSR.
Phototrophic Fe(II) oxidation by Rhodopseudomonas palustris TIE‐1 in organic and Fe(II)‐rich conditions
Authors: Nikeleit Verena , Maisch Markus , Byrne James M. , Harwood Caroline , Kappler Andreas , Bryce Casey 
Published: March 2024

AbstractRhodopseudomonas palustris TIE‐1 grows photoautotrophically with Fe(II) as an electron donor and photoheterotrophically with a variety of organic substrates. However, it is unclear whether R. palustris TIE‐1 conducts Fe(II) oxidation in conditions where organic substrates and Fe(II) are available simultaneously. In addition, the effect of organic co‐substrates on Fe(II) oxidation rates or the identity of Fe(III) minerals formed is unknown. We incubated R. palustris TIE‐1 with 2 mM Fe(II), amended with 0.6 mM organic co‐substrate, and in the presence/absence of CO2. We found that in the absence of CO2, only the organic co‐substrates acetate, lactate and pyruvate, but not Fe(II), were consumed. When CO2 was present, Fe(II) and all organic substrates were consumed. Acetate, butyrate and pyruvate were consumed before Fe(II) oxidation commenced, whereas lactate and glucose were consumed at the same time as Fe(II) oxidation proceeded. Lactate, pyruvate and glucose increased the Fe(II) oxidation rate significantly (by up to threefold in the case of lactate). 57Fe Mössbauer spectroscopy revealed that short‐range ordered Fe(III) oxyhydroxides were formed under all conditions. This study demonstrates phototrophic Fe(II) oxidation proceeds even in the presence of organic compounds, and that the simultaneous oxidation of organic substrates can stimulate Fe(II) oxidation.
Diabetic mastopathy: A case report and literature review on a mimic of breast carcinoma in patients with diabetes
Authors: Li Wai Si Crystal , Chan Shun Yan 
Published: March 2024

AbstractDiabetic mastopathy is a rare benign breast condition that mimics breast carcinoma in patients with diabetes. Clinicians must differentiate it from malignant causes because of differences in prognosis and management. This paper presents a case report of an 87‐year‐old lady with type 2 diabetes and diabetic mastopathy. We also review the literature on the pathogenesis, clinical presentation, diagnostic workup and management of diabetic mastopathy.
Geographic differences in psychological symptoms, sleep quality, and quality of life in patients with inflammatory bowel disease: A multicenter study in China
Authors: Liu Chuan , Zhang Ji Xiang , Li Jin Ting , Wei Yu Ping , Zhen Jun Hai , Wu Yan Rui , He Hao Dong , Chen Ying , Sun Jia Yi , Tan Cheng , Wang Shuo , Xiong Qiu Tang , Liao Fei , Yang Xiao Cui , An Ping , Liu Zhong Chun , Jiang Chang Qing , Shi Jie , Wu Kai Chun , Dong Wei Guo ,   the Psychology Club of Inflammatory Bowel Disease Group, Chinese Society of Gastroenterology, Chinese Medical Association, Chinese Association for Mental Hygiene
Published: March 2024

ObjectiveWe aimed to explore the geographic differences in psychological symptoms, sleep quality, and quality of life (QoL) among adult patients with inflammatory bowel disease (IBD).MethodsA unified questionnaire was developed to collect data on psychological status and QoL of IBD patients from 42 hospitals across 22 provinces, municipalities, and autonomous regions in China's mainland from September 2021 to May 2022.ResultsA total of 2478 patients with IBD were surveyed. The proportions of patients with anxiety (28.5% vs 23.1%), depression (32.3% vs 27.8%), and poor QoL (44.8% vs 32.2%) were significantly higher in patients from the northern region compared to the southern region (all P < 0.05). In the western region, the proportions of patients with anxiety (31.9% vs 23.0%), depression (37.7% vs 26.7%), sleep disturbances (64.5% vs 58.5%), and poor QoL (44.9% vs 34.8%) were significantly higher than in the eastern and central regions (all P < 0.01). Patients from inland regions had significantly higher rates of anxiety (27.1% vs 23.3%), depression (32.5% vs 26.0%), sleep disturbance (62.0% vs 57.7%), and poor QoL (43.5% vs 29.9%) compared to those from coastal regions (all P < 0.05). In economically underdeveloped areas, the proportions of patients with depression (33.1% vs 28.5%) and poor QoL (52.0% vs 32.4%) were significantly higher than in economically (relatively) developed areas (both P < 0.05).ConclusionThere are significant geographic differences in psychological symptoms, sleep quality, and QoL among Chinese patients with IBD, which might provide valuable insights for global IBD research and clinical practice.
Bayesian hierarchical modelling of size spectra
Authors: Wesner Jeff S. , Pomeranz Justin P. F. , Junker James R. , Gjoni Vojsava 
Published: March 2024

Abstract

A fundamental pattern in ecology is that smaller organisms are more abundant than larger organisms. This pattern is known as the individual size distribution (ISD), which is the frequency distribution of all individual body sizes in an ecosystem.

The ISD is described by a power law and a major goal of size spectra analyses is to estimate the exponent of the power law, λ. However, while numerous methods have been developed to do this, they have focused almost exclusively on estimating λ from single samples.

Here, we develop an extension of the truncated Pareto distribution within the probabilistic modelling language Stan. We use it to estimate multiple λs simultaneously in a hierarchical modelling approach.

The most important result is the ability to examine hypotheses related to size spectra, including the assessment of fixed and random effects, within a single Bayesian generalized mixed model. While the example here uses size spectra, the technique can also be generalized to any data that follow a power law distribution.
Effect of long‐term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis
Authors: Hastings Waylon J. , Ye Qiaofeng , Wolf Sarah E. , Ryan Calen P. , Das Sai Krupa , Huffman Kim M. , Kobor Michael S. , Kraus William E. , MacIsaac Julia L. , Martin Corby K. , Racette Susan B. , Redman Leanne M. , Belsky Daniel W. , Shalev Idan 
Published: March 2024

AbstractCaloric restriction (CR) modifies lifespan and aging biology in animal models. The Comprehensive Assessment of Long‐Term Effects of Reducing Intake of Energy (CALERIE™) 2 trial tested translation of these findings to humans. CALERIE™ randomized healthy, nonobese men and premenopausal women (age 21–50y; BMI 22.0–27.9 kg/m2), to 25% CR or ad‐libitum (AL) control (2:1) for 2 years. Prior analyses of CALERIE™ participants' blood chemistries, immunology, and epigenetic data suggest the 2‐year CR intervention slowed biological aging. Here, we extend these analyses to test effects of CR on telomere length (TL) attrition. TL was quantified in blood samples collected at baseline, 12‐, and 24‐months by quantitative PCR (absolute TL; aTL) and a published DNA‐methylation algorithm (DNAmTL). Intent‐to‐treat analysis found no significant differences in TL attrition across the first year, although there were trends toward increased attrition in the CR group for both aTL and DNAmTL measurements. When accounting for adherence heterogeneity with an Effect‐of‐Treatment‐on‐the‐Treated analysis, greater CR dose was associated with increased DNAmTL attrition during the baseline to 12‐month weight‐loss period. By contrast, both CR group status and increased CR were associated with reduced aTL attrition over the month 12 to month 24 weight maintenance period. No differences were observed when considering TL change across the study duration from baseline to 24‐months, leaving it unclear whether CR‐related effects reflect long‐term detriments to telomere fidelity, a hormesis‐like adaptation to decreased energy availability, or measurement error and insufficient statistical power. Unraveling these trends will be a focus of future CALERIE™ analyses and trials.
Adult self‐reported childhood maltreatment types are associated with treatment satisfaction and alcohol relapse in patients with comorbid substance use and mental health disorders
Authors: Luciani Karling R. , Johal Priya K. , Chao Thomas , Thiessen Karina A. , Schütz Christian G. 
Published: March 2024

AbstractBackground and ObjectivesIndividuals with comorbid substance use and mental health disorders (concurrent disorders; CD) report poor treatment outcomes, high prevalence of childhood maltreatment, and mostly negative experiences with treatment. No studies to date have examined childhood maltreatment and treatment outcomes in CD. This study investigated self‐reported childhood maltreatment as it relates to treatment satisfaction and substance use relapse among CD patients.MethodsThe 258 CD inpatients completed a self‐report questionnaire package, comprising the Childhood Trauma Questionnaire and the Inpatient Consumer Survey (ICS). Childhood maltreatment was assessed according to five subtypes and self‐perceived treatment satisfaction was rated across six ICS domains. Psychiatric diagnoses, substance use status and relapse data were retrieved via patient medical charts.ResultsEmotional neglect was associated with lower ratings across all ICS domains and physical neglect was associated with a lower rating for ‘outcome of care’. Childhood sexual abuse was associated with a greater likelihood of alcohol relapse. No other relationships were statistically significant.Discussion and ConclusionsThe presence of childhood neglect (but not abuse) was more associated with overall treatment dissatisfaction, and sexual abuse alone increased the likelihood of alcohol relapse. These findings suggest some early adverse experiences in CD patients may increase negative experiences in treatment while others contribute to the risk of substance use. Broader longitudinal research is needed to examine the trajectory leading to negative outcomes.Scientific SignificanceThis is the first study to report differential patterns of association by type of childhood maltreatment on negative outcomes in treatment among CD patients.
Outpatient labor induction—Exploring future potential by assessing eligibility in a historical cohort
Authors: Marsdal Kjersti Engen , Sørbye Ingvil Krarup , Bernitz Stine , Sve Ranveig Elise T. , Ask Kristine , Lukasse Mirjam 
Published: March 2024

AbstractIntroductionLabor induction rates have increased over the last decades, and in many high‐income countries, more than one in four labors are induced. Outpatient management of labor induction has been suggested in low‐risk pregnancies to improve women's birth experiences while also promoting a more efficient use of healthcare resources. The primary aim of this paper was to assess the proportion of women in a historical cohort that would have been eligible for outpatient labor induction with oral misoprostol. Second, we wanted to report safety outcomes and assess efficacy outcomes for mothers and infants in pregnancies that met the criteria for outpatient care.Material and methodsCriteria for outpatient labor induction with oral misoprostol were applied to a historical cohort of women with induction of labor at two Norwegian tertiary hospitals in the period January 1, through July 31, 2021. The criteria included low‐risk women with an unscarred uterus expecting a healthy, singleton baby in cephalic position at term. The primary outcome was the proportion of women eligible for outpatient labor induction. Secondary outcomes included reasons for ineligibility and, for eligible women, safety and efficacy outcomes.ResultsOverall, 29.7% of the 1320 women who underwent labor induction in a singleton term pregnancy met the criteria for outpatient labor induction. We identified two serious adverse events that potentially could have occurred outside the hospital if the women had received outpatient care. The mean duration from initiation of labor induction to administration of the last misoprostol was 22.4 h. One in 14 multiparous women gave birth within 3 h after the last misoprostol dose.ConclusionsIn this historical cohort, three in ten women met the criteria for outpatient management of labor induction with oral misoprostol. Serious adverse events were rare. The average time span from the initiation of labor induction to the last misoprostol was nearly 24 h. This suggests a potential for low‐risk women with an induced labor to spend a substantial period of time at home before labor onset. However, larger studies testing or evaluating labor induction with oral misoprostol as an outpatient procedure are needed to draw conclusions.
Transthoracic transdiaphragmatic approach in laparoscopic liver resection for hepatocellular carcinoma in a patient with severe obesity and history of deceased donor liver transplantation
Authors: Umemura Akira , Nitta Hiroyuki , Takeda Daiki , Katagiri Hirokatsu , Kanno Shoji , Sasaki Akira 
Published: March 2024

AbstractBackgroundThe transthoracic transdiaphragmatic approach (TTA) for hepatic tumors in laparoscopic liver resection (LLR) is not usually employed because the caudal approach via the abdominal cavity is the gold standard in LLRs. Here, we present a case of LLR via TTA for hepatocellular carcinoma (HCC) in a patient with severe obesity and a history of deceased donor liver transplantation (DDLT).Materials and Surgical TechniqueThe patient, a 64‐year‐old man with severe obesity and a history of DDLT, was referred to our hospital to undergo LLR for HCC located at the cranial side of segment IV. We decided to perform LLR via TTA because of concerns about the effect of severe adhesion, the difficulty of encircling the hepatoduodenal ligament, and the impact of severe obesity on the completion of LLR. Under general anesthesia with differential lung ventilation, we started to perform transthoracic ultrasonography to determine the diaphragmatic transection line. Then, we transected the diaphragm and revealed the tumor. We marked the parenchymal transection line with a 1‐cm margin and then employed precoagulation of the hepatic parenchyma along the transection line. We performed parenchymal transection and clipped the responsible Glissonean pedicle at the bottom of the tumor. The diaphragm was closed using 3–0 nonabsorbable sutures with suture clips after the resected specimen was extracted.DiscussionWe successfully performed LLR via TTA without hepatic inflow control. However, further studies are warranted to define the indications and recommendations for TTA in LLRs in the near future.
Long‐term results of Waldenström macroglobulinaemia treatment by bendamustine and rituximab: A study on behalf of the French Innovative Leukemia Organization (FILO)
Authors: Laribi Kamel , Poulain Stéphanie , Willems Lise , Merabet Fatiha , Herbaux Charles , Roos‐Weil Damien , Laribi de Materre Inès , Roussel Xavier , Nudel Morgane , Tricot Sabine , Dupuis Jehan , Le Calloch Ronan , Bareau Benoit , Leblond Véronique 
Published: March 2024

SummaryThe bendamustine–rituximab (BR) schedule is an efficient first‐line therapy in Waldenström macroglobulinaemia (WM). A previous analysis of 69 patients who received this treatment confirmed a high response rate and good progression‐free (PFS) and overall survival (OS). With a median follow‐up of 76.1 months (95% confidence interval [CI] 69.9–80.6), 5‐year outcome is still excellent at 66.63% (95% CI 56.09–79.17) for PFS and 80.01% (95% CI 70.82–90.41) for OS. The rate of secondary cancers is 17.66% (IQR 7.99–27.64) at 66 months. Relapsed patients who received ibrutinib as second‐line clearly benefited from this schedule. This confirms current recommendations suggesting BR long‐term efficacy as first‐line option in WM.