bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green tea polyphenol stimulates cancer preventive effects of celecoxib in human lung cancer cells by upregulation of GADD153 gene
Authors: Suganuma Masami , Kurusu Miki , Suzuki Kaori , Tasaki Emi , Fujiki Hirota 
Published: February 2006

AbstractTo more clearly understand the molecular mechanisms involved in synergistic enhancement of cancer preventive activity with the green tea polyphenol (−)‐epigallocatechin gallate (EGCG), we examined the effects of cotreatment with EGCG plus celecoxib, a cyclooxygenase‐2 selective inhibitor. We specifically looked for induction of apoptosis and expression of apoptosis related genes, with emphasis on growth arrest and DNA damage‐inducible 153 (GADD153) gene, in human lung cancer cell line PC‐9: Cotreatment with EGCG plus celecoxib strongly induced the expression of both GADD153 mRNA level and protein in PC‐9 cells, while neither EGCG nor celecoxib alone did. However, cotreatment did not induce expression of other apoptosis related genes, p21WAF1 and GADD45. Judging by upregulation of GADD153, only cotreatment with EGCG plus celecoxib synergistically induced apoptosis of PC‐9 cells. Synergistic effects with the combination were also observed in 2 other lung cancer cell lines, A549 and ChaGo K‐1. Furthermore, EGCG did not enhance GADD153 gene expression or apoptosis induction in PC‐9 cells in combination with N‐(4‐hydroxyphenyl)retinamide or with aspirin. Thus, upregulation of GADD153 is closely correlated with synergistic enhancement of apoptosis with EGCG. Cotreatment also activated the mitogen‐activated protein kinases (MAPKs), such as ERK1/2 and p38 MAPK: Preteatment with PD98059 (ERK1/2 inhibitor) and UO126 (selective MEK inhibitor) abrogated both upregulation of GADD153 and synergistic induction of apoptosis of PC‐9 cells, while SB203580 (p38 MAPK inhibitor) did not do so, indicating that GADD153 expression was mediated through the ERK signaling pathway. These findings indicate that high upregulation of GADD153 is a key requirement for cancer prevention in combination with EGCG. © 2006 Wiley‐Liss, Inc.
Computation of hydration free energies of organic solutes with an implicit water model
Authors: Basilevsky Mikhail V. , Leontyev Igor V. , Luschekina Sofia V. , Kondakova Olga A. , Sulimov Vladimir B. 
Published: February 2006

AbstractA new approach for computing hydration free energies ΔGsolv of organic solutes is formulated and parameterized. The method combines a conventional PCM (polarizable continuum model) computation for the electrostatic component ΔGel of ΔGsolv and a specially detailed algorithm for treating the complementary nonelectrostatic contributions (ΔGnel). The novel features include the following: (a) two different cavities are used for treating ΔGel and ΔGnel. For the latter case the cavity is larger and based on thermal atomic radii (i.e., slightly reduced van der Waals radii). (b) The cavitation component of ΔGnel is taken to be proportional to the volume of the large cavity. (c) In the treatment of van der Waals interactions, all solute atoms are counted explicitly. The corresponding interaction energies are computed as integrals over the surface of the larger cavity; they are based on Lennard Jones (LJ) type potentials for individual solute atoms. The weighting coefficients of these LJ terms are considered as fitting parameters. Testing this method on a collection of 278 uncharged organic solutes gave satisfactory results. The average error (RMSD) between calculated and experimental free energy values varies between 0.15 and 0.5 kcal/mol for different classes of solutes. The larger deviations found for the case of oxygen compounds are probably due to a poor approximation of H‐bonding in terms of LJ potentials. For the seven compounds with poorest fit to experiment, the error exceeds 1.5 kcal/mol; these outlier points were not included in the parameterization procedure. Several possible origins of these errors are discussed. © 2006 Wiley Periodicals, Inc. J Comput Chem 27: 552–570, 2006
Ylidic radical–molecule reactions
Authors: Xie Hong‐Bin , Ding Yi‐Hong , Sun Chia‐Chung 
Published: February 2006

AbstractThe known reactions between a neutral radical and a neutral closed‐shell σ‐type molecule are generally associated with the atom/group‐abstraction (e.g., CN, OH reactions) or the carbenoid insertion processes (e.g., CH reactions). In this article, we describe a new type of neutral radical–molecule reaction that feature the nucleophilic addition and elimination mechanism based on the systematic Gaussian‐3//MP2(full)/6‐31G(d) investigations on the PH3CH+HX model reactions (X = CH3, NH2, OH, F, CH2F, CHF2, CF3, NHCH3/CH2NH2, OCH3/CH2OH). The novel properties are found to benefit both from the radical and ylidic characters of PH3CH, and the type of reagent HX determines the nucleophilic addition reactivity. The present work is the first study on the chemical reactivity of the ylidic radicals. © 2006 Wiley Periodicals, Inc. J Comput Chem 27: 545–551, 2006
Introduction to the special issue: Addressing mental health disparities through culturally competent research and community‐based practice
Authors: Kim Irene J. , Lorion Raymond P. 
Published: February 2006

AbstractAs we enter a new millennium in which rapid demographic changes in the United States are predicted to dramatically change the face of “mainstream” America, it is essential that researchers, practitioners, and policymakers come to grips with mental health disparities through culturally competent research and community‐based practice. This introduction to the special issue outlines the rationale for this volume and briefly describes the main underlying themes across this set of articles. The purpose of this special issue is twofold: (a) to present studies which serve as illustrative examples of empirical research focusing on the needs and characteristics of diverse populations within various contexts in the community and also point to implications for culturally sensitive intervention/prevention; and (b) to provide directions for future research in this area of culturally competent mental health services and treatment. Implications for future research, practice, and policy are discussed.© 2006 Wiley Periodicals, Inc.
Well‐being in the context of workplace ethnic diversity
Authors: Enchautegui‐de‐Jesús Noemí , Hughes Diane , Johnston Kristen E. , Oh Hyun Joo 
Published: February 2006

AbstractThis research examined the relation between the effects of workplace diversity (defined as the proportion of coworkers of same ethnicity as the respondent) and psychosomatic complaints, psychological well‐being, life satisfaction, and job satisfaction. A sample of 648 African American and Latino workers was surveyed in Chicago and New York City. A nonlinear (inverted U‐shaped) relationship between co‐ethnicity and the outcomes was found, such that poorer psychological functioning was observed among workers with a very small or a very high proportion of co‐ethnic coworkers. The importance of disentangling the meaning of diversity in light of occupational segregation issues is discussed. © 2006 Wiley Periodicals, Inc.
Strategies to improve minority access to public mental health services in California: Description and preliminary evaluation
Authors: Snowden Lonnie , Masland Mary , Ma Yifei , Ciemens Elizabeth 
Published: February 2006

AbstractThe present study documented and evaluated steps taken by public mental health administrators to recruit members of underrepresented ethnic minority populations into treatment. By surveying county‐level ethnic program specialists in the decentralized California state system, the study identified strategies considered effective for reaching African American, Asian American, Latino, and Native Americans communities and overcoming barriers to treatment‐seeking. In multivariate analysis, strategies were linked to ethnic‐specific Medi‐Cal penetration rates calculated as measures of access. Results indicated that undertaking outreach activities was associated with greater access for Latinos and Native Americans. For Asian Americans, hiring bilingual or bicultural staff was associated with greater access but having a bilingual or bicultural receptionist was associated with lesser access. For all minority groups as well as for Whites, the overall supply of mental health practitioners in the county was strongly associated with greater access. The study documented real‐world efforts to improve minority access and, despite limitations imposed by its cross‐sectional design, provided preliminary evidence of effectiveness. © 2006 Wiley Periodicals, Inc.
Cultural competency: From philosophy to research and practice
Authors: Sue Stanley 
Published: February 2006

AbstractCultural competency in the delivery of mental health services has gained considerable momentum. This momentum has been accompanied by questions about the meaning, usefulness, and precision of cultural competency. The author argues that cultural competency is composed of general processes (scientific mindedness, dynamic sizing, and culture‐specific skills), as well as a series of concrete and trainable strategies. The incorporation of these processes and strategies into treatment can improve treatment outcomes with clients from diverse cultural backgrounds. © 2006 Wiley Periodicals, Inc.
Phylogenetic memory of developing mammalian dentition
Authors: Peterkova Renata , Lesot Hervé , Peterka Miroslav 
Published: February 2006

AbstractStructures suppressed during evolution can be retraced due to atavisms and vestiges. Atavism is an exceptional emergence of an ancestral form in a living individual. In contrast, ancestral vestige regularly occurs in all members of an actual species. We surveyed data about the vestigial and atavistic teeth in mammals, updated them by recent findings in mouse and human embryos, and discussed their ontogenetic and evolutionary implications. In the mouse incisor and diastema regions, dental placodes are transiently distinct being morphologically similar to the early tooth primordia in reptiles. Two large vestigial buds emerge in front of the prospective first molar and presumably correspond to the premolars eliminated during mouse evolution. The incorporation of the posterior premolar vestige into the lower first molar illustrates the putative mechanism of evolutionary disappearance of the last premolar in the mice. In mutant mice, devious development of the ancestral tooth primordia might lead to their revivification and origin of atavistic supernumerary teeth. Similarity in the developmental schedule between three molars in mice and the respective third and fourth deciduous premolar and the first molar in humans raises a question about putative homology of these teeth. The complex patterning of the vestibular and dental epithelium in human embryos is reminiscent of the pattern of “Zahnreihen” in lower vertebrates. A hypothesis was presented about the developmental relationship between the structures at the external aspect of the dentition in mammals (oral vestibule, pre‐lacteal teeth, paramolar cusps/teeth), the tooth glands in reptiles, and the earliest teeth in lower vertebrates. J. Exp. Zool. (Mol. Dev. Evol.) 306B, 2006. © 2006 Wiley‐Liss, Inc.
Sufficient conditions for λ′‐optimality in graphs with girth g
Authors: Balbuena C. , García‐Vázquez P. , Marcote X. 
Published: February 2006

AbstractFor a connected graph the restricted edge‐connectivity λ′(G) is defined as the minimum cardinality of an edge‐cut over all edge‐cuts S such that there are no isolated vertices in G–S. A graph G is said to
be λ′‐optimal if λ′(G) = ξ(G), where ξ(G) is the minimum edge‐degree in G defined as ξ(G) = min{d(u) + d(v) − 2:uv ∈ E(G)}, d(u) denoting the degree of a vertex u. A. Hellwig and L. Volkmann [Sufficient conditions for λ′‐optimality in graphs of diameter 2, Discrete Math 283 (2004), 113–120] gave a sufficient condition for λ′‐optimality in graphs of diameter 2. In this paper, we generalize this condition in graphs of diameter g − 1, g being the girth of the graph, and show that a graph G with diameter at most g − 2 is λ′‐optimal. © 2006 Wiley Periodicals, Inc. J Graph Theory 52: 73–86, 2006
Cycle lengths in graphs with large minimum degree
Authors: Nikiforov V. , Schelp R. H. 
Published: February 2006

AbstractOur main result is the following theorem.Let k ≥ 2 be an integer, G be a graph of sufficiently large order n, and δ(G) ≥ n/k. Then:

G contains a cycle of length t for every even integer t ∈ [4, δ(G) + 1].
If G is nonbipartite then G contains a cycle of length t for every odd integer t ∈ [2k − 1, δ(G) + 1], unless k ≥ 6 and G belongs to a known exceptional class.

© 2006 Wiley Periodicals, Inc. J Graph Theory 52: 157–170, 2006
Decolorization of synthetic dyes by the deuteromycete Pestalotiopsis guepinii CLPS no. 786 strain
Authors: Nazareno Saparrat Mario Carlos , Hammer Elke 
Published: February 2006

AbstractThe ability of Pestalotiopsis guepinii CLPS no. 786 to decolorize 13 dyes of varied structure was analyzed and compared with that of the basidiomycete Phanerochaete chrysosporium . Nine dyes representing anthrapyridone, azo, N‐heterocyclic and triphenylmethane chromophores, but none with the O‐heterocyclic group, were decolorized by P. guepinii when added to an agar medium. Studies with liquid cultures revealed that P. guepinii transformed both crystal violet and methylene blue B dyes, and adsorbed different chromophores onto its mycelium. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A simple system for biofilm potential monitoring in drinking water
Authors: Delahaye Eric , Levi Yves , Leblon Gérard , Montiel Antoine 
Published: February 2006

AbstractSAGEP‐EAU DE PARIS produces drinking water for the city of Paris (France). In order to supply a high quality water, one of the main SAGEP's concerns is to monitor the Biofilm Formation Potentials of the produced drinking waters.Biofilm incubators were installed at the outlet of three Water Treatment Plants (WTP). These incubators allowed biofilm formation and quantification in terms of Fixed Total Organic Carbon (FTOC), fixed culturable bacteria (HPC‐R2A) and fixed total bacteria.During this study, quantitative differences appeared between the biofilms formed at the outlet of the three WTPs, leading to different classifications of the Biofilm Formation Potentials of the three produced waters, depending on the used parameter for biofilms quantification. This observation underlined the necessity of a multi‐parametric approach for the study of biofilms.More generally, our results validated the use of these sturdy stainless steel incubators, highly adapted to industrial field conditions, for the monitoring of Biofilm Formation Potentials in drinking water networks. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Unusual envelopes associated with parasporal inclusions of a mosquitocidal Bacillus thuringiensis serovar fukuokaensis isolate
Authors: Shisa Noriko , Maeda Minoru , Ohba Michio 
Published: February 2006

AbstractA mosquitocidal soil isolate of Bacillus thuringiensis serovar fukuokaensis (H3ade) produced spherical parasporal inclusions measuring 0.6–0.7 µm in diameter. Inclusion matrix was homogeneous substance surrounded by a thick, highly electron‐dense envelope 30–50 nm in thickness. The envelopes were associated with both intracellular and extracellular inclusions. Densely woven network was the inner structure of the envelope. Often, inclusions had round‐shaped, enveloped small protrusions on the surface. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The effects of salinity and other factors on nitrite reduction by Ochrobactrum anthropi 49187
Authors: Causey Margaret B. , Beane Kimberly N. , Wolf Joe R. 
Published: February 2006

AbstractThe nitrite reductase (NIR) gene was cloned from Ochrobactrum anthropi 49187 and found to contain an open reading frame of 1131 nucleotides, encoding a polypeptide of 376 amino acids. The O. anthropi NIR gene encodes a copper‐type dissimilatory reductase based on sequence homology with other genes. The polypeptide product is predicted to form a trimeric holoenzyme of 37 kDa subunits based on molecular weight estimates of extracts in activity gels. Expression of the enzyme is up‐regulated by nitrate, presumably through the intermediate nitrite, and its activity is influenced by inhibitors. Salinity enhances the activity of existing NIR enzyme, but appears to decrease the expression of new enzyme. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
An event‐based jet‐stream climatology and typology
Authors: Koch Patrick , Wernli Heini , Davies Huw C. 
Published: February 2006

AbstractA novel climatology is developed for upper‐tropospheric jet streams, which is complementary to and an alternative for the traditional depictions of the time‐mean jets. It entails identifying the occurrence of a jet event at a given location and then compiling the spatial frequency distribution of such events. The resulting climatology, derived using the ERA‐15 reanalysis data set of the ECMWF for the period 1979–1993 indicates that (1) in both hemispheres the annual cycle of jet events takes the form of comparatively smooth transition from a quasi‐annular structure in summer to a more spiral‐like structure in winter with a temporally asymmetric return to the summer pattern; (2) the hemispheres differ primarily in the amplitude of the frequencies and the longitudinal overlap of the spiral portion of the pattern.In addition, the jet events are subdivided using a two‐class typology comprising shallow and deep jets whose vertical shear (sic. baroclinicity) are/are not confined principally to the upper troposphere. This provides a conceptually simple and dynamically meaningful classification since deep jets are more likely to spawn tropospheric‐spanning cyclones. The accompanying climatology displays important longitudinal variations and significant inter‐hemispheric differences.A comparison is drawn between these new and conventional climatologies and typologies. Also, comments are proffered on the relationship between, on the one hand, the patterns of jet frequency including the differing distributions of the shallow and deep types and, on the other hand, the location of the time‐mean jets and the downstream storm tracks. Copyright © 2006 Royal Meteorological Society.
Ibuprofen inhibition of tendon cell migration and down‐regulation of paxillin expression
Authors: Tsai Wen‐Chung , Hsu Chih‐Chin , Chen Carl P.C. , Chen Max J.L. , Lin Miao‐Sui , Pang Jong‐Hwei S. 
Published: February 2006

AbstractSports‐related tendon injuries are commonly treated with nonsteroidal antiinflammatory drugs. Tendon healing requires migration of tendon cells to the repair site, followed by proliferation and synthesis of the extracellular matrix. This study was designed to determine the effect of ibuprofen on the migration of tendon cells intrinsic to rat Achilles tendon. Whether a correlation exits between this effect and the expression of paxillin, which is a positive regulator of cell spreading and migration, was also investigated. The migration of tendon cells was evaluated ex vivo by counting the number of initial outgrowths from the tendon explants and in vitro by transwell filter migration assay. The spreading of tendon cells in culture was also evaluated microscopically. The mRNA and protein expressions of paxillin were determined by reverse transcription‐polymerase chain reaction (RT‐PCR) and Western blot analysis. Dose‐dependent ibuprofen inhibition was demonstrated on the migration of tendon cells both ex vivo, and in vitro. Similar inhibition was also observed on the spreading of tendon cells. Suppression of mRNA expression and protein level of paxillin was revealed by RT‐PCR and Western blot analyses. The expression of focal adhesion kinase (FAK) and tyrosine phosphorylation of FAK remained unchanged. In conclusion, ibuprofen inhibits tendon cell migration in a process that is probably mediated by the down‐regulation of paxillin. © 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 24:551–558, 2006
Effect of TGF‐β inducible early gene deficiency on flexor tendon healing
Authors: Tsubone Tetsu , Moran Steven L. , Subramaniam M. , Amadio P.C. , Spelsberg T.C. , An K.N. 
Published: February 2006

AbstractThe role of transforming growth factor β (TGF‐β) in tendon healing is still not clearly established. TGF‐β affects gene expression primarily through the activation of the Smad signaling pathway. The first step in the Smad pathway is the expression of TGF‐β inducible early gene (TIEG). Recently, a TIEG knockout mouse has been developed. The purpose of this study was to examine the healing potential of flexor tendons in mice lacking the TIEG gene, and to further examine what role the TIEG pathway plays in flexor tendon repair. Twenty‐two mice, consisting of 11 normal wild‐type mice and 11 TIEG knockout mice, were euthanized at 8 to 12 weeks of age. The second through fifth FDL tendons of both hind feet were transected and repaired in zone 2. The repaired tendons were removed from the mice and placed into tissue culture. Tendons were then examined at days 3, 7, 14, 21, and 42 after surgery. Hematoxylin and eosin (HE) staining and immunohistochemical staining for TGF‐β, collagen type I, and collagen type III were performed. Reverse transcriptase polymerase chain reaction (RT‐PCR) was performed to examine expression of TGF‐β1, β2, β3, and collagen type I and III. At 42 days after surgery, HE staining showed coaptation of lacerated tendon ends in both groups. Both groups showed healing of the lacerated tendon, but the chronologic expression pattern of TGF‐β was different between the knockout and normal tendons. TIEG deficient tendons had delayed expression of TGF‐β when compared with control tendons. The collagen mRNA expression pattern was similar with both groups, but the expression level was different, with TIEG knockout tendons having a lower expression of collagen type I mRNA (p < 0.001). TGF‐β is thought to play a major role in tendon healing. Healing of tendons in the TIEG knockout mouse suggests the possibility of tendon healing in the absence of the Smad pathway. The knockout mouse model described in the present study provides a novel means for further understanding of the tendon healing process through isolated deletion of specific growth factors. © 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 24:569–575, 2006