bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel human disease with abnormal prion protein sensitive to protease
Authors: Gambetti Pierluigi , Dong Zhiqian , Yuan Jue , Xiao Xiangzhu , Zheng Mengjie , Alshekhlee Amer , Castellani Rudy , Cohen Mark , Barria Marcelo A. , Gonzalez‐Romero D. , Belay Ermias D. , Schonberger Lawrence B. , Marder Karen , Harris Carrie , Burke James R. , Montine Thomas , Wisniewski Thomas , Dickson Dennis W. , Soto Claudio , Hulette Christine M. , Mastrianni James A. , Kong Qingzhong , Zou Wen‐Quan 
Published: June 2008

AbstractObjectiveTo report a novel prion disease characterized by distinct histopathological and immunostaining features, and associated with an abnormal isoform of the prion protein (PrP) that, contrary to the common prion diseases, is predominantly sensitive to protease digestion.MethodsEleven subjects were investigated at the National Prion Disease Pathology Surveillance Center for clinical, histopathological, immunohistochemical, genotypical, and PrP characteristics.ResultsPatients presented with behavioral and psychiatric manifestations on average at 62 years, whereas mean disease duration was 20 months. The type of spongiform degeneration, the PrP immunostaining pattern, and the presence of microplaques distinguished these cases from those with known prion diseases. Typical protease‐resistant PrP was undetectable in the cerebral neocortex with standard diagnostic procedures. After enrichment, abnormal PrP was detected at concentrations 16 times lower than common prion diseases; it included nearly 4 times less protease‐resistant PrP, which formed a distinct electrophoretic profile. The subjects examined comprised about 3% of sporadic cases evaluated by the National Prion Disease Pathology Surveillance Center. Although several subjects had family histories of dementia, no mutations were found in the PrP gene open reading frame.InterpretationThe distinct histopathological, PrP immunohistochemical, and physicochemical features, together with the homogeneous genotype, indicate that this is a previously unidentified type of disease involving the PrP, which we designated “protease‐sensitive prionopathy” (or PSPr). Protease‐sensitive prionopathy is not rare among prion diseases, and it may be even more prevalent than our data indicate because protease‐sensitive prionopathy cases are likely also to be classified within the group of non‐Alzheimer's dementias. Ann Neurol 2008;63:697–708
Characteristics of research output in social sciences and humanities: From a research evaluation perspective
Authors: Huang Mu‐hsuan , Chang Yu‐wei 
Published: June 2008

AbstractThe goal of research evaluation is to reveal the achievement and progress of research. Research output offers a basis for empirical evaluation. A fair and just research evaluation should take into account the diversity of research output across disciplines and include all major forms of research publications. This article reviews the literature on the nature of research output in social sciences and humanities in terms of the characteristics of research publications, and then discusses the implications for the research evaluation of social sciences and humanities researchers.
Lysosomal trapping of amodiaquine: impact on transport across intestinal epithelia models
Authors: Hayeshi Rose , Masimirembwa Collen , Mukanganyama Stanley , Ungell Anna‐Lena B. 
Published: June 2008

AbstractThe lipophilic weak base amodiaquine is an antimalarial drug that has been in use for over 40 years. Little is known of amodiaquine's mechanism of transport across membranes. Transport experiments of amodiaquine in Caco‐2 cells showed a low recovery of 30% and rapid disappearance from the apical chamber. Compounds structurally similar to amodiaquine, and those affecting non‐specific binding of amodiaquine or the pH of the system, were tested to unravel the mechanism behind these observations. Chloroquine and ammonium chloride increased the transmonolayer permeability of amodiaquine and decreased its accumulation in Caco‐2 cells, whereas BSA had no effect. Chloroquine and BSA decreased plastic binding whereas ammonium chloride had no effect. This suggests that amodiaquine is trapped in acidic cell compartments such as lysosomes. Amodiaquine was also trapped in rat intestinal tissue. In addition, permeability from the apical to basolateral direction was significantly higher, suggesting an active uptake over the apical membrane of the rat tissue. It can be concluded that amodiaquine is trapped in acidic cell compartments due to its base properties and recovery may be improved by the use of ammonium chloride rather than BSA in transport experiments. Further studies are required to confirm whether amodiaquine is actively absorbed in the intestine. Copyright © 2008 John Wiley & Sons, Ltd.
Procedural modeling of urban zone by optimization
Authors: Wang Liying , Hua Wei , Bao Hujun 
Published: June 2008

AbstractProcedural modeling technology may be applied for constructing a large‐scale urban scene. Most of the previous studies have exploited a grammar‐based modeling method to generate models. Nevertheless, we formulate the urban planning as a constrained layout optimization problem, propose an algorithm to solve the problem, and procedurally generate models of the urban zone. It produces an extensive urban virtual environment for computer games and simulations at low cost. We optimize a cost function to distribute buildings and roads subject to some urban planning constraints. We employ particle swarm optimization and two‐step path planning to find the optimal solution, which is further interpreted as the 2D blueprint of the urban zone. During the optimization, we adopt the spatial pattern tree structure to reduce the combinational search space greatly. 3D city models in large scale are then assembled according to the 2D blueprints. Experimental results prove that our method can efficiently produce the virtual urban scene similar to that designed by urban planners. Copyright © 2008 John Wiley & Sons, Ltd.
ChemInform Abstract: New Mixed Tellurides of Nickel and Group 13—14 Metals Ni3‐δMTe2 (M: Sn, In, Ga).
Authors: Litvinenko O. N. , Kuznetsov A. N. , Olenev A. V. , Popovkin B. A. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Structures of Isotypic Aluminides CeRuAl and CeRhAl.
Authors: Gribanov A. V. , Tursina A. I. , Grytsiv A. V. , Murashova E. V. , Bukhan'ko N. G. , Rogl P. , Seropegin Y. D. , Giester G. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hexacopper(I) Phosphorus(V) Bromide Penta(selenide/sulfide), Cu6P(Se0.7S0.3)5Br.
Authors: Gagor A. , Pietraszko A. , Panko V. V. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Molecular Structure and Dynamics in the Low Temperature (Orthorhombic) Phase of NH3BH3
Authors: Cho Herman , et al. et al. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Low‐Temperature Solvothermal Synthesis of Phosphorus‐Rich Transition‐Metal Phosphides.
Authors: Barry Brian M. , Gillan Edward G. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Syntheses and Crystal Structures of Sr7H12X2 (X: Cl, Br).
Authors: Reckeweg Olaf , Molstad Jay C. , Levy Scott , Hoch Constantin , DiSalvo Francis J. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Metal‐Rich Mixed Chalcogenides with an Intergrowth Structure: Ni5.68SiSe2, Ni5.46GeSe2 and Ni5.42GeTe2.
Authors: Isaeva A. A. , Baranov A. I. , Doert Th. , Ruck M. , Kulbachinskii V. A. , Lunin R. A. , Popovkin B. A. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Hydrogenation Catalyzed by a Rhodium Complex of (R)‐(tert‐Butylmethylphosphino)(di‐tert‐butylphosphino)methane: Scope of Enantioselectivity and Mechanistic Study.
Authors: Gridnev Ilya D. , Imamoto Tsuneo , Hoge Garrett , Kouchi Mitsuhiro , Takahashi Hidetoshi 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Thermal Intramolecular Alder—Ene Cycloisomerization of 1,6‐Allenynes.
Authors: Buisine Olivier , Gandon Vincent , Fensterbank Louis , Aubert Corinne , Malacria Max 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Yttrium‐Mediated Conversion of Vinyl Grignard Reagent to a 1,2‐Dimetalated Ethane and Its Synthetic Application.
Authors: Tanaka Ryoichi , Sanjiki Hiroaki , Urabe Hirokazu 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Acetylation of N‐Heteroaryl Bromides via PdCl2/(o‐tolyl)3P Catalyzed Heck Reactions.
Authors: He Tianxiong , Tao Xiaochun , Wu Xinyan , Cai Lisheng , Pike Victor W. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Triphenylphosphine Oxide Supported on Non‐Cross‐Linked Maleimide—Styrene Copolymer: Application as a Novel Hendrickson Reagent.
Authors: Mahdavi Hossein , Amani Javad 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recoverable Phase‐Transfer Catalysts with Fluorinated Anions: Generation and Reactions of Dichlorocarbene and CCl3 Anion in the Heterogeneous System KOH(s)/CHCl3/nBu4NPF6.
Authors: Kryshtal Galina V. , Zhdankina Galina M. , Zlotin Sergei G. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Gold(I)‐Catalyzed Cycloisomerization of 3‐Methoxy‐1,6‐enynes Featuring Tandem Cyclization and [3,3]‐Sigmatropic Rearrangement.
Authors: Bae Hyo J. , Baskar Baburaj , An Sang E. , Cheong Jae Y. , Thangadurai Daniel T. , Hwang In‐Chul , Rhee Young H. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Formation of Iodobenzene Derivatives from 1‐(Methylthio)‐3‐tosylhexa‐1,3‐dien‐5‐ynes via Iodine‐Induced Intramolecular Cyclization.
Authors: Matsumoto Shoji , Takase Kenji , Ogura Katsuyuki 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Henry Reaction Catalyzed by Trianglamine—Cu(OAc)2 Complex under Solvent‐Free Conditions.
Authors: Tanaka Koichi , Hachiken Satoshi 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: First Evidence of Proline Acting as a Bifunctional Catalyst in the Baylis—Hillman Reaction Between Alkyl Vinyl Ketones and Aryl Aldehydes.
Authors: Gruttadauria Michelangelo , Giacalone Francesco , Lo Meo Paolo , Mossuto Marculescu Adriana , Riela Serena , Noto Renato 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Strategy for Designing Non‐C2‐Symmetric Monometallic Bifunctional Catalysts and Their Application in Enantioselective Cyanation of Aldehydes.
Authors: Yang Fei , Wei Siping , Chen Chien‐An , Xi Peihua , Yang Li , Lan Jingbo , Gau Han‐Mou , You Jingsong 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Chiral (salen)AlIII Complex Catalyzed Asymmetric Cyanosilylation of Aldehydes.
Authors: Zeng Zebing , Zhao Guofeng , Zhou Zhenghong , Tang Chuchi 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Sterically Demanding, Sulfonated, Triarylphosphines: Application to Palladium‐Catalyzed Cross‐Coupling, Steric and Electronic Properties, and Coordination Chemistry.
Authors: Moore Lucas R. , Western Elizabeth C. , Craciun Raluca , Spruell Jason M. , Dixon David A. , O'Halloran Kevin P. , Shaughnessy Kevin H. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cyclopropyl Building Blocks in Organic Synthesis. Part 146. 3‐Spirocyclopropanedihydro‐ and ‐tetrahydropyridin‐4‐ones from Nitrone Cycloadducts of Bicyclopropylidene via 1‐(1′‐Aminomethylcyclopropyl)cyclopropanol and PdII Catalysis.
Authors: Revuelta Julia , Cicchi Stefano , de Meijere Armin , Brandi Alberto 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Azirines Containing Aldehyde Functionality and Their Utilization as Synthetic Tools for Five Membered Oxazoles and Isoxazoles.
Authors: Brahma Sulagna , Ray Jayanta K. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Synthesis of Highly Substituted Furans via the Electrophilic Cyclization of 1‐(1‐Alkynyl)‐cyclopropyl Ketones.
Authors: Huang Xian , Fu Weijun , Miao Maozhong 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Microwave Assisted Polymerization of Fluorinated 2‐Phenyl‐2‐oxazolines (III): The Fastest 2‐Oxazoline Monomer to Date.
Authors: Lobert Matthias , Koehn Uwe , Hoogenboom Richard , Schubert Ulrich S. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Strategy for C—H Activation of Pyridines: Direct C‐2 Selective Alkenylation of Pyridines by Nickel/Lewis Acid Catalysis.
Authors: Nakao Yoshiaki , Kanyiva Kyalo Stephen , Hiyama Tamejiro 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: (Dimethoxy‐ and Dihalopyridyl)boronic Acids and Highly Functionalized Heteroarylpyridines by Suzuki Cross‐Coupling Reactions.
Authors: Smith Amy E. , Clapham Kate M. , Batsanov Andrei S. , Bryce Martin R. , Tarbit Brian 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iodine‐Catalyzed Synthesis of α,α′‐Bis(substituted benzylidene)‐1‐carbethoxy‐4‐piperidone.
Authors: Ameen Mohamed A. , Ahmed Essam Kh. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1,3‐Dipolar Cycloaddition of Stabilized Azomethine Ylides to Alkenyl Quinolines (III): An Efficient Route to Polyfunctionalized 3‐Pyrrolidinylquinoline Derivatives (V).
Authors: Bouraiou Abdelmalek , Debache Abdelmadjid , Rhouati Salah , Carboni Bertrand , Belfaitah Ali 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Syntheses of Oxazolo[4,5‐c]pyridine and 6‐Azaindole.
Authors: Tjosaas Freddy , Kjerstad Ivar Broendbo , Fiksdahl Anne 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Expedient One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones and ‐thiones Catalyzed by ZIRCONIA Nanopowder. An Improved Protocol for the Biginelli Cyclocondensation Compounds in “Dry Media”.
Authors: Gopalakrishnan Mannathusamy , Sureshkumar Purusothaman , Thanusu Jeyaraman , Kanagarajan Vijayakumar , Ezhilarasi Muthuvel R. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Green and High Efficient Synthesis of Triaza‐benzo[b]fluoren‐6‐one Derivatives in Water under Microwave Irradiation.
Authors: Shao Qingqing , Tu Shujiang , Li Chunmei , Cao Longji , Zhou Dianxiang , Wang Qian , Jiang Bo , Zhang Yan , Hao Wenjuan 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Synthesis of N(3)‐ (IV) and O‐Acylmethyl Derivatives (III) of 2‐Methylthio‐4(3H)‐quinazolinone.
Authors: Burbuliene Milda M. , Mazeikaite Rita , Vainilavicius Povilas 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.