bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Search for Novel Human Pancreatic α‐Amylase Inhibitors: High‐Throughput Screening of Terrestrial and Marine Natural Product Extracts
Authors: Tarling Chris A. , Woods Kate , Zhang Ran , Brastianos Harry C. , Brayer Gary D. , Andersen Raymond J. , Withers Stephen G. 
Published: January 2008

AbstractSpecific inhibitors of human pancreatic α‐amylase (HPA) have potential as oral agents for the control of blood glucose levels in the treatment of diabetes and obesity. In a search for novel inhibitors, a library of 30 000 crude biological extracts of terrestrial and marine origin has been screened. A number of inhibitory extracts were identified, of which the most potent was subjected to bioassay‐guided purification. A family of three glycosylated acyl flavonols, montbretins A–C, was thereby identified and characterized as competitive amylase inhibitors, with Ki values ranging from 8.1–6100 nM. Competitive inhibition by myricetin, which corresponds to the flavone core, and noncompetitive inhibition by a second fragment, ethyl caffeiate, suggest a binding mode for these inhibitors.
Binding of Topotecan to a Nicked DNA Oligomer in Solution
Authors: Bocian W. , Kawęcki R. , Bednarek E. , Sitkowski J. , Williamson M. P. , Hansen P. E. , Kozerski L. 
Published: January 2008

AbstractTopotecan (TPT) is in clinical use as an antitumor agent. It acts by binding to the covalent complex formed between nicked DNA and topoisomerase I, and inserts itself into the single‐strand nick, thereby inhibiting the religation of the nick and acting as a poison. A crystal structure analysis of the ternary complex has shown how the drug binds (B. L. Staker, K. Hjerrild, M. D. Feese, C. A. Behnke, A. B. Burgin, L. Stewart, Proc. Natl. Acad. Sci. U.S.A., 2002, 99, 15 387–15 392), but has left a number of unanswered questions. Herein, we use NMR spectroscopy and molecular modeling to show that the solution structure of a complex of TPT with nicked natural DNA is similar, but not identical to the crystal conformation, and that other geometries are of very low population. We also show that the lactone form of TPT binds approximately 40 times more strongly than the ring‐opened carboxylate.
Synthesis of a Novel Pentagastrin‐Drug Conjugate for a Targeted Tumor Therapy
Authors: Tietze Lutz F. , Panknin Olaf , Major Felix , Krewer Birgit 
Published: January 2008

AbstractThe synthesis of the novel pentagastrin seco‐CBI conjugate 3, which is based on the highly cytotoxic antitumor antibiotic (+)‐duocarmycin SA (1), is reported. A key step in the synthesis is the palladium‐catalyzed carbonylation of aryl bromide 7 to give the benzyl ester 16, which is transformed into the new seco‐CBI derivative 21 bearing a carboxylic acid ester moiety. Subsequent transformation of 21 into an activated ester followed by the introduction of β‐alanine and tetragastrin led to the new pentagastrin drug 3 that contains a peptide moiety for targeting cancer cells expressing CCK‐B/gastrin receptors.
ChemInform Abstract: Structural Studies on a High‐Pressure Polymorph of NaYSi2O6.
Authors: Kahlenberg Volker , Konzett Juergen , Kaindl Reinhard 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Layered Ruthenium Hexagonal Perovskites: The New Series [Ba2Br2‐2x(CO3)x] [Ban+1RunO3n+3] with n = 2, 3, 4, 5.
Authors: Kauffmann Matthieu , Roussel Pascal , Abraham Francis 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Structures of the La3AgSnSe7 and R3Ag1‐δSnS7 (R: La, Ce; δ = 0.18‐0.19) Compounds.
Authors: Daszkiewicz M. , Gulay L. D. , Pietraszko A. , Shemet V. Ya. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Characterization, Photoluminescnece and EPR Investigations of Mn Doped MgAl2O4 Phosphors.
Authors: Singh Vijay , Chakradhar R. P. S. , Rao J. L. , Kim Dong‐Kuk 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Neutron Powder Diffraction Experiments on the Layered Triangular‐Lattice Antiferromagnets RbFe(MoO4)2 and CsFe(SO4)2.
Authors: Inami Toshiya 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydrogen Adsorption in Dehydrated Variants of the Cyano‐Bridged Framework Compounds A2Zn3 [Fe(CN)6]2×xH2O (A: H, Li, Na, K, Rb).
Authors: Kaye Steven S. , Long Jeffrey R. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel KTP‐Like Complex Phosphates KMII0.33Nb0.67PO5 (MII: Mn, Co).
Authors: Babaryk A. A. , Zatovsky I. V. , Baumer V. N. , Slobodyanik N. S. , Nagorny P. G. , Shishkin O. V. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Structure, and Magnetic Properties of a Novel Pillard Layered Iron(III) Arsenate, [4,4′‐bpyH2]3 [Fe9(H2O)6F3 (HAsO4)12(AsO4)2] ×2H2O.
Authors: Rao Vandavasi K. , Green Mark A. , Pati Swapan K. , Natarajan Srinivasan 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Titanium Mediated Asymmetric Aldol Reaction with α‐Fluoropropionimide Enolates
Authors: Brunet Vincent A. , O'Hagan David , Slawin Alexandra M. Z. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Catalysis with tropos Ligands in Chiral Ionic Liquids.
Authors: Schmitkamp Mike , Chen Dianjun , Leitner Walter , Klankermayer Juergen , Francio Giancarlo 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: N‐Heterocyclic Carbene—Palladium Complexes [(NHC)Pd(acac)Cl]: Improved Synthesis and Catalytic Activity in Large‐Scale Cross‐Coupling Reactions.
Authors: Marion Nicolas , de Fremont Pierre , Puijk Iris M. , Ecarnot Elise C. , Amoroso Dino , Bell Andrew , Nolan Steven P. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Intermolecular Radical Carboaminohydroxylation of Olefins with Aryl Diazonium Salts and TEMPO.
Authors: Heinrich Markus R. , Wetzel Alexander , Kirschstein Marcel 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Fluorination and Chlorination of Nitroalkyl Groups.
Authors: Butler Philip , Golding Bernard T. , Laval Gilles , Loghmani‐Khouzani Hossein , Ranjbar‐Karimi Reza , Sadeghi Majid M. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Amination of Heterocyclic Compounds with O‐Benzoylhydroxylamine Derivatives.
Authors: Parlanti Luca , Discordia Robert P. , Hynes John Jr. , Miller Michael M. , O'Grady Harold R. , Shi Zhongping 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Amination of the Baylis—Hillman Acetates in Ethanol.
Authors: Park Young Sang , Cho Min Young , Kwon Young Bum , Yoo Byung Woo , Yoon Cheol Min 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: SO42‐/SnO2: Efficient, Chemoselective, and Reusable Catalyst for Acylation of Alcohols, Phenols, and Amines at Room Temperature.
Authors: Satam Jitendra R. , Gawande Manoj B. , Deshpande Sameer S. , Jayaram Radha V. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Three‐Component One‐Pot Process to Propargylic Amines and Related Amide and Sulfonamide Compounds: Application to the Construction of 2‐(Aminomethyl)benzofurans and Indoles.
Authors: Russo Olivier , Messaoudi Samir , Hamze Abdallah , Olivi Nathanael , Peyrat Jean‐Francois , Brion Jean‐Daniel , Sicsic Sames , Berque‐Bestel Isabelle , Alami Mouad 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Terminal Olefins from Aldehydes Through Enol Triflate Reduction.
Authors: Pandey Sushil K. , Greene Andrew E. , Poisson Jean‐Francois 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ionic Liquid‐Promoted Stereoselective Synthesis of (Z)‐Vinyl Bromides by [bmIm]OH under Organic Solvent‐Free Conditions: A Green Approach.
Authors: Ranu Brindaban C. , Banerjee Subhash , Gupta Jhinuk 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chiral Tetraaminophosphonium Salt‐Mediated Asymmetric Direct Henry Reaction.
Authors: Uraguchi Daisuke , Sakaki Sawako , Ooi Takashi 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Evaluation of Zard Trifluoromethylketone Synthesis for the Preparation of Potential Bifunctional Fluorinated Synthons.
Authors: Diter Patrick , Magnier Emmanuel , Blazejewski Jean‐Claude 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chiral Bisformamides as Effective Organocatalysts for the Asymmetric One‐Pot, Three‐Component Strecker Reaction.
Authors: Wen Yuehong , Xiong Yan , Chang Lu , Huang Jinglun , Liu Xiaohua , Feng Xiaoming 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: CuI/1,10‐Phenanthroline: An Efficient Catalyst System for the Cyanation of Aryl Halides.
Authors: Zhu Yi‐Zhong , Cai Chun 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: (1R,2S)‐4‐(2‐Cyano‐cyclohexyl‐oxy)‐2‐trifluoromethyl‐benzonitrile, a Potent Androgen Receptor Antagonist for Stimulating Hair Growth and Reducing Sebum Production.
Authors: Hu Lain‐Yen , et al. et al. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nucleophilic (Phenylsulfinyl)difluoromethylation of Carbonyl Compounds with Difluoromethyl Phenyl Sulfoxide.
Authors: Zhu Lingui , Li Ya , Ni Chuanfa , Hu Jinbo , Beier Petr , Wang Ying , Prakash G. K. Surya , Olah George A. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: HbA/H2O2: An Efficient Biomimetic Catalytic System for the Oxidation of Sulfides to Sulfoxides.
Authors: Kumar Atul , Akanksha Akanksha 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mild and Convenient Synthesis of Organic Carbamates from Amines and Carbon Dioxide Using Tetraethylammonium Superoxide.
Authors: Singh Krishna Nand 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: AlAr3(THF): Highly Efficient Reagents for Cross‐Couplings with Aryl Bromides and Chlorides Catalyzed by the Economic Palladium Complex of PCy3.
Authors: Ku Shih‐Lun , Hui Xin‐Ping , Chen Chien‐An , Kuo Yi‐Ying , Gau Han‐Mou 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ni‐Catalyzed Cross‐Coupling Reaction of Aryl Chlorides with Arylboronic Acids in IPA Without Using a Reducing Reagent.
Authors: Zhou Li , Miao Qingqing , He Ren , Feng Xiujuan , Bao Ming 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrophilic Aromatic Aroylation with CF3‐Bearing Arenecarboxylic Acid Derivatives: Reaction Behavior and Acidic Mediator Dependence.
Authors: Akiko Okamoto , Katsuya Maeyama , Hideaki Oike , Noriyuki Yonezawa 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Direct Asymmetric Catalytic 1,2‐Addition of RZnX to Aldehydes Promoted by AlMe3 and Reversal of Expected Stereochemistry.
Authors: Shannon Jonathan , Bernier David , Rawson Daniel , Woodward Simon 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: One‐Pot Synthesis of the Derivatives of 2‐Cyclopent‐2‐en‐1‐one by SOCl2/EtOH.
Authors: Hu Zhiguo , Dong Zhibing 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Structural Elucidation of Novel Bisarylmethylidenes of Cyclic Enones.
Authors: Abaee M. Saeed , Mojtahedi Mohammad M. , Zahedi M. Mehdi , Sharifi Roholah , Mesbah A. Wahid , Massa Werner 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: High Dopamine Transporter Selectivity Can Be Displayed by Remarkably Simple Non‐Nitrogen Containing Inhibitors.
Authors: Boye Soeren V. , Ortega‐Caballero Fernando , Sinning Steffen , Wiborg Ove , Jensen Henrik H. , Bols Mikael 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparative‐Scale Synthesis of 3,3,3‐Trifluoropropene Oxide.
Authors: Ramachandran P. Veeraraghavan , Padiya Kamlesh J. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium‐Catalyzed [3 + 2] Cycloaddition of Carbon Dioxide and Trimethylenemethane under Mild Conditions.
Authors: Greco George E. , Gleason Brittany L. , Lowery Tiffany A. , Kier Matthew J. , Hollander Lisa B. , Gibbs Shoshanah A. , Worthy Amanda D. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Synthesis of Highly Aryl‐Substituted Pyrrole Carboxylates as Useful Medicinal Chemistry Leads.
Authors: Bhatt Ulhas , Duffy Bryan C. , Guzzo Peter R. , Cheng Leifeng , Elebring Thomas 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diastereoselective 1,3‐Dipolar Cycloaddition Reactions Between Azomethine Ylides and Chiral Acrylates Derived from Methyl (S)‐ and (R)‐Lactate — Synthesis of Hepatitis C Virus RNA‐Dependent RNA Polymerase Inhibitors.
Authors: Najera Carmen , Retamosa M. de Gracia , Sansano Jose M. , de Cozar Abel , Cossio Fernando P. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.