bluuebunny/crossref_metadata_2025_split huggingface dataset:
The book collection of A.N. Nortsov: the history of formation, thematic coverage and significance for the creative laboratory of the owner
Authors: Zhitin R. M. , Topilsky A. G. 
Published: March 2024

INTRODUCTION. The book heritage of the region’s personal libraries analysis allows us to understand the reading interests’ specifics of different generations of library owners, and to clarify important aspects of the intellectual and spiritual growth of Tambov bibliophiles in the process of working with books. In this regard, the stages of Alexey Nikolaevich Nortsov’s biography are considered in the context of its influence on bibliophilism.MATERIALS AND METHODS. The fundamental methodology in the work is the principles of objectivity and historicism. The historicism principle made it possible to analyze the book collection of A.N. Nortsov in close connection with the specifics of the epoch and the reader’s needs of the bibliophile. The objectivity principle is i mplemented on the basis of a detailed analysis of historical sources, which makes it possible to comprehensively study the process of completing the Norts library.RESULTS AND DISCUSSION. A passion for genealogy and history of his native land inevitably left a mark on A.N. Nortsov’s library collection. His personal collection included voluminous collections of books on local history, regional archeology, and genealogy.CONCLUSION. The study of A.N. Nortsov’s personal library complements the cultural and educational portrait of its owner. The extensive thematic repertoire of the presented books allows us to speak about the broad reading interests of Alexey Nikolaevich, his high artistic taste. At the same time, the library collection acted as a creative laboratory for writing numerous works on the history of the Tambov Region, philosophical, religious, socio-political works.
Gambaran Telur Cacing pada Kangkung yang Dijual di Pasar Segiri
Authors: Safitri Annisa Eka , Azahra Sresta , Nur Rica Fitri 
Published: March 2024

Penyakit yang menjadi masalah kesehatan bagi masyarakat Indonesia salah satunya ialah infeksi yang diakibatkan oleh cacing yang ditularkan dari tanah yang sering disebut dengan Soil Transmitted Helminth (STH). Parasit yang termasuk ke dalam golongan ini ialah Ascaris lumbricoides, Trichuris trichiura, Strongyloides stercoralis, Ancylostoma duodenale, dan Necator americanus. Penelitian ini bertujuan mengetahui ada tidaknya telur cacing STH pada sayuran kangkung dengan tiga perlakuan yang berbeda yaitu dengan perlakuan tidak dicuci, dicuci dengan air mengalir, dan dicuci dengan air sabun. Penelitian ini bersifat deskriptif, penelitian dilakukan di Laboratorium Parasitologi Poltekkes Kemenkes Kaltim Tahun 2021. Sampel yang digunakan adalah kangkung yang dijual di pasar Segiri. Teknik pengambilan sampel menggunakan tenik simple random sampling dengan analisis univariat. Penelitian ini menggunakan data primer yang diperoleh dari hasil uji laboratorium dengan pemeriksaan metode Sedimentasi. Hasil penelitian ini didapatkan hasil negatif telur STH pada sampel yang diperiksa namun ditemukan 3 sampel positif larva rhabditiform pada perlakuan ang tidak dicuci.
The Validitas Modul Keanekaragaman Hayati Berbasis Pendekatan Saintifik Untuk Siswa Fase E
Authors: Sari Risa Indriana , Rosba Evrialiani , Zikra Zikra 
Published: March 2024

Penelitian ini bertujuan untuk menghasilkan modul keanekaragaman hayati berbasis pendekatan saintifik untuk siswa fase E yang valid. Jenis penelitian pengembangan menggunakan model pengembangan 4-D yaitu define, design, develop, dan disseminate. Penelitian ini hanya sampai tahap pengembangan yaitu tahap uji validitas. Instrument penelitian menggunakan angket yang terdiri dari 4 aspek penilaian diantaranya kelayakan isi, kebahasaan, penyajian, dan kegrafikan. Pengujian angket dilakukan pada 4 orang ahli. Teknik analisis data meliputi data primer yang diperoleh dari kuesioner yang di isi oleh validator dan dianalisis menggunakan skala likert. Berdasarkan hasil penelitian diperoleh validitas dari empat aspek yaitu kelayakan isi sebesar 89 % dengan kriteria sangat valid, aspek kebahasaan 93 % dengan kriteria sangat valid, aspek penyajian 88 % kriteria sangat valid dan aspek kegrafikan sebesar 92 % dengan kriteria sangat valid. Hasil nilai dari keseluruhan untuk uji validitas modul diperoleh nilai 90 % dengan kriteria sangat valid. Dengan demikian kesimpulannya modul keanekaragaman hayati berbasis pendekatan saintifik untuk siswa fase yaitu sangat valid.
Implementasi Metode Qiro’ati pada Anak di TK Al-Azhar 1 Samarinda
Authors: Muyasaroh Muyasaroh 
Published: March 2024

Metode dalam belajar membaca Al-Qur’an merupakan cara atau teknik yang diterapkan pada proses pembelajaran agar tercapai tujuan yang diinginkan yakni dapat lancar, baik dan benar ketika membaca al-Qur’an. Metode Qiro’ati ialah teknik yang dilakukan dengan cara langsung memasukkan dan mempraktikkan bacaan Al-Qur’an secara tartil sesuai dengan hukum dalam ilmu tajwid. Ini adalah penelitian kualitatif. Oleh karena itu pendekatan yang digunakan dalam penelitian ini adalah penelitian lapangan. Subjek sebagai sumber data dalam penelitian ini adalah guru dan kepala sekolah TK Al-Azhar 1 Samarinda. Pengumpulan data dilakukan dengan observasi partisipatif, wawancara, dan dokumentasi. Teknik analisis data dilakukan dengan reduksi data, display data, penarikan kesimpulan data dan verifikasi. Program yang diterapkan saat pembelajaran Qiro’ati yakni klasikal individual. Adapun faktor pendukung pada penerapan metode Qiro’ati di TK Al-Azhar 1 yaitu: guru yang sudah profesional, waktu belajar yang cukup, sarana lengkap dan prasarana yang menunjang, orang tua yang mendukung serta hadiah sebagai apresiasi.
Pengawasan Orang Tua terhadap Penggunaan Gadget pada Anak Usia Dini
Authors: Sari Wulan , Machmud Hadi , Anhusadar Laode 
Published: March 2024

Tujuan penelitian ini untuk memberikan gambaran tentang bagaimana bentuk penggunaan gadget pada anak usia 5-6 dan bentuk pengawasan orang tua terhadap penggunaan gadget pada anak usia 5-6 tahun di Desa Sumberjaya Kabupaten Konawe Selatan. Pendekatan yang digunakan adalah pendekatan deskriptif dengan metode penelitian kualaitatif. Sumber data dari penelitian ini diperoleh dari informan yaitu orang tua dari anak-anak yang gemar bermain gadget dan tokoh masyarakat Desa Sumberjaya. Teknik pengumpulan data dilakukan dengan wawancara dan observasi. Teknik analisis data yang digunakan adalah model interaktif yang dikembangkan oleh Miles dan Huberman yang terdiri dari tiga teknik, yaitu reduksi data, penyajian data dan panarikan kesimpulan. Hasil penelitian ini menunjukan bahwa bentuk penggunaan gadget pada anak usia dini yang ditemukan di Desa Sumberjaya Kabupaten Konawe Selatan : dengan penggunaan aplikasi youtube oleh 10 anak, penggunaan aplikasi tiktok oleh 4 anak dan penggunaan aplikasi game oleh 2 anak. sementara untuk bentuk pengawasan orang tua pada penggunaan gadget anak usia 5-6 tahun di Desa Sumberjaya Kabupaten Konawe Selatan yaitu terdapat 9 orang tua yang memberi nasehat, 6 orang tua yang memberi batasan waktu dan 4 orang tua yang memberikan sanksi. Bentuk-bentuk pengawasan orang tua sangat penting dilakukan dalam penggunaan gadget pada anak agar anak tidak kecanduan gadget dan perkembangannya tidak terganggu.
Penggunaan Media Permainan Tradisional Tembak Tutus Untuk Meningkatkan Kognitif Anak Usia Dini
Authors: Aida Nur , Muzakki Muzakki , Saudah Saudah 
Published: March 2024

Penelitian ini bertujuan untuk mengetahui penggunaan media permainan tradisional tembak tutus dan peningkatan kognitif anak kelompok abu bakar usia 4-5 tahun dalam penggunaan media permainan tradisional tembak tutus di RA Ar-Raudhah Desa Hampalit Kabupaten Katingan. Penelitian ini menggunakan penelitian tindakan kelas (PTK) yang dilakukan dalam dua siklus dengan model Kemmis dan MC Taggart; setiap siklus terdiri dari empat pertemuan. Tempat penelitian dilaksanakan di RA Ar-Raudhah Desa Hampalit Kabupaten Katingan. Subjek penelitian anak kelompok abu bakar usia 4-5 tahun yang terdiri dari 13 anak. Tehnik pengumpulan data menggunakan observasi, dokumentasi, dan wawancara. Kriteria keberhasilan penelitian sebesar 85%, untuk menentukan berhasilan atau tidak dalam penelitian. Berdasarkan hasil penelitian menunjukkan bahwa penggunaan media permainan tradisional tembak tutus pada siklus I, perkembangan kognitif anak belum mencapai tingkat perkembangan yang optimal, diadakan perbaikan langkah-langkah penggunaan media permainan tradisional tembak tutus pada siklus II. Selanjutnya dalam perkembangan kognitif anak mengenal pola ABC, dan mengenal lambang huruf, serta menulis huruf yang telah dicontohkan belum berkembang secara optimal pada pra siklus diperoleh hasil sebesar 38,4%. Siklus I hasil rata-rata diperoleh sebesar 62,1%, tetapi belum mencapai indikator keberhasilan atau target yang harus dicapai sebesar 85%, sehingga dilanjutkan lagi pada siklus kedua menghasilkan rata-rata sebesar 93,7% dan kriteria penilaian berkembang sangat baik (BSB).
The Pengaruh Bimbingan Belajar Terhadap Motivasi dan Hasil Belajar IPS Siswa
Authors: Dewi Rina Kusuma , Putranto Anggoro 
Published: March 2024

Penelitian ini dilakukan dengan tujuan yaitu; (1) Dapat mengetahui pengaruh bimbingan luar sekolah terhadap motivasi belajar siswa pada mata pelajaran IPS kelas IX di SMP Negeri 1 Srengat.(2) Dapat mengetahui pengaruh bimbingan luar sekolah terhadap hasil belajar siswa pada mata pelajaran IPS kelas IX di SMP Negri 1 Srengat. Metode penelitian yang diterapkan adalah quasi experiment dengan desain penelitian Single subject design. Populasi pada penelitian yakni semua siswa kelas IX, sampel yang di gunakan yakni 2 kelas IX-I Sebagai Kelas eksperimen dan Kelas IX- J sebagai kelas kontrol. Metode pengumpulan data dalam penelitian adalah angket dan dokumentasi. untuk mengukur keduanya menggunakan uji instrumen validitas dan rehabilitas, uji prasyarat dengan uji normalitas dan homogenitas, serta uji hipotesis menggunakan uji t-test. Hasil dari penelitian yang dilakukan di SMP Negeri 1 Srengat adalah sebagai berikut (1) Ditemukan pengaruh yang signifikan antara bimbingan belajar luar sekolah terhadap motivasi belajar. Hal ini di buktikan dengan hasil uji T-test nilai Sig. (2-tailed) adalah 0,000, maka berdasarkan prinsip pengambilan keputusan0.000 < 0,05 maka Ho di tolak dan Ha diterima. (2) Ditemukan pengaruh yang signifikan antara bimbingan belajar luar sekolah terhadap hasil belajar. Hal ini diverifikasi dengan hasil uji T-test nilai Sig. (2-tailed) adalah 0,000, maka berdasarkan kriteria pengambilan keputusan0.000 < 0,05 berarti Ha diterima sedangkan Ho ditolak.
Kata kunci: Bimbingan Belajar, Motivasi Belajar, Hasil Belajar
Fourier series method for the stability solution of simply supported thin beams on two-parameter elastic foundations of the Pasternak, Filonenko-Borodich, Hetenyi or Vlasov models
Authors: Ike Charles Chinwuba 
Published: March 2024

The analysis of stability problems of beams on two-parameter foundations (Bo2PFs) is an important part of their design for compressive loads. This work presents novel first principles derivation of the governing differential equations of elastic stability (GDES) of thin beams resting on two-parameter elastic foundations of the Pasternak, Filonenko-Borodich, Hetenyi or Vlasov models. The requirements of translational and rotational equilibrium of all the applied, reactive and internal forces on an infinitesimal segment of the Bo2PF and the laws of infinitesimal calculus were used to formulate the GDES as a fourth order ordinary differential equation (ODE) in terms of the transverse displacement function ux. The GDES is non-homogeneous in the presence of applied transverse load qx but homogeneous when qx vanishes. This study presents the Fourier series method (FSM) for solving the governing differential equation of stability (GDES) for the case of Dirichlet boundary conditions. The FSM has the advantage of amenability to differentiation, and integration due to the orthogonality properties of the sinusoidal functions. Implementation of the FSM by assuming the unknown function in the GDES as a Fourier series of infinite terms and the exploitation of orthogonalization simplifies the problem to an algebraic eigenvalue problem which is the characteristic buckling equation. The exact eigenvalues are found by algebraic solution of the buckling equation. The exact eigenvalues were used to find the exact buckling loads and the exact buckling load coefficients. The critical buckling load was found to correspond to the first buckling mode (n= 1), and is identical with previous solutions in the literature. Numerical calculations for the critical buckling load parameters Kcr were presented for the Bo2PF problem for values of the dimensionless foundation parameters k-1= 0, k-2= 0; k-1= 100, k-2= 0; k-1= 0, k-2= 1; k-1= 100, k-2= 100; k-1= 0, k-2= 2.5; k-1= 100, k-2= 2.5. The present solutions were compared with previous solutions for Kcr in the literature. The comparison shows that the present FSM results are identical with previous results obtained using various other methods such as Recursive Differentiation Method, Finite Element Method, Generalized Integral Transform Method (GITM) and Stodola-Vianello Iteration Method. The study has illustrated the effectiveness of the FSM for solving Bo2PFs.
Hydrological dynamics and water resource availability in the Rift Valley Lakes Basin (Ethiopia), using a WEAP model
Authors: Mohammed Mulugeta , Birhanu Belete , Abegaz Fentaw 
Published: March 2024

Abstract
This study aims to assess hydrologic dynamics and the water resource potential of the Rift Valley Lake Basin (RVLB) in Ethiopia using the Water Evaluation and Planning System (WEAP) model. The surface water of the RVLB comprises streamflow and an open water system. The model was configured with 13 catchments and a monthly time series of approximately 43 years (1981–2022) to address the spatial variability of rainfall-runoff interaction. Statistical performance indicators were used to evaluate the accuracy of the model in simulating streamflows, and the results showed that the coefficient of determination (R2) ranges from 0.82–0.93, Nash-Sutcliffe coefficient of efficiency (NSE) ranges from 0.68–0.86, percentage of bias (PBIAS) ranges from –9.45 to –1.85, standard deviation ratio (RSR) ranges from 0.35 to 0.59 and index of agreement (IA) ranges from 0.62 to 0.84. The available surface water for abstraction is estimated to be 358 million cubic meters (MCM) available as lake water abstraction, and 6,534 MCM as streamflow water, making it a total surface water flow of 6,892 MCM. Considering the temporal distribution of the surface water sources, 67.5% is available in the rainy season, June–October, and 32.5% during the dry period, November–May, in the basin.
Synthesis of Bis-thiazoles Tethered 1,4-Dihydropyridine and Pyridine Linkers via Simple Oxidation and their Molecular Docking as VEGFR -TK Inhibitors
Authors: Al-Humaidi Jehan Y. , Riyadh Sayed M. , Farag Basant , Zaki Magdi E. A. , Abolibda Tariq Z. , Gomha Sobhi M. 
Published: March 2024

Aim:
In this study, a neoteric and expedient oxidation method is applied for a
variety of Hantzsch 1,4-dihydropyridine derivatives such as 1,4-dihydro-
2,6-dimethyl-3,5-diacetylpyridine, 3,5-bis-hydrazono--2,6-dimethyl-1,4-dihydropyridine,
and 3,5-bis-thiazoly-2,6-dimethyl-1,4-dihydro pyridines.

Method:
This simple oxidation is based upon the in situ generation of nitrous acid from
an aqueous sodium nitrite and acetic acid mixture and could be used to downgrade costs,
sustain resources, and minimize chemical wastes. Also, a molecular modeling strategy
was used to study the mechanism of action for various derivatives of bis-hydrazinylidene-
thiazole as the protein Vascular Endothelial Growth Factor Receptor Tyrosine Kinase
(VEGFR TK) inhibitor through evaluating their binding scores and modes compared
with Sorafenib as a reference standard.

Result:
The results revealed that the interaction of hydrazinylidene and thiazole as an anticancer
Tyrosine Kinase inhibitor has been improved. Conclusion: Additionally, the
compounds exhibiting the highest activity were assessed for their potential anticancer effects
against HepG-2, MCF-7, and WI-38 cells, and the outcomes demonstrated encouraging
activity against cancer.
EACVP: An ESM-2 LM Framework Combined CNN and CBAM
Attention to Predict Anti-coronavirus Peptides
Authors: Zhang Shengli , Jing Yuanyuan , Liang Yunyun 
Published: March 2024

Background::
The novel coronavirus pneumonia (COVID-19) outbreak in
late 2019 killed millions worldwide. Coronaviruses cause diseases such as severe acute
respiratory syndrome (SARS-Cov) and SARS-COV-2. Many peptides in the host defense
system have antiviral activity. How to establish a set of efficient models to identify
anti-coronavirus peptides is a meaningful study.

Methods::
Given this, a new prediction model EACVP is proposed. This model uses the
evolutionary scale language model (ESM-2 LM) to characterize peptide sequence information.
The ESM model is a natural language processing model trained by machine
learning technology. It is trained on a highly diverse and dense dataset (UR50/D
2021_04) and uses the pre-trained language model to obtain peptide sequence features
with 320 dimensions. Compared with traditional feature extraction methods, the information
represented by ESM-2 LM is more comprehensive and stable. Then, the features are
input into the convolutional neural network (CNN), and the convolutional block attention
module (CBAM) lightweight attention module is used to perform attention operations
on CNN in space dimension and channel dimension. To verify the rationality of
the model structure, we performed ablation experiments on the benchmark and independent
test datasets. We compared the EACVP with existing methods on the independent
test dataset.

Results::
Experimental results show that ACC, F1-score, and MCC are 3.95%, 35.65%
and 0.0725 higher than the most advanced methods, respectively. At the same time, we
tested EACVP on ENNAVIA-C and ENNAVIA-D data sets, and the results showed that
EACVP has good migration and is a powerful tool for predicting anti-coronavirus peptides.

Conclusion::
The results prove that this model EACVP could fully characterize the peptide
information and achieve high prediction accuracy. It can be generalized to different
data sets. The data and code of the article have been uploaded to https://github.-
com/JYY625/EACVP.git.
Artificial Intelligence Application for Anti-tumor Drug Synergy Prediction
Authors: Peng Zheng , Ding Yanling , Zhang Pengfei , Lv Xiaolan , Li Zepeng , Zhou Xiaoling , Huang Shigao 
Published: March 2024

:
Currently, the main therapeutic methods for cancer include surgery, radiation
therapy, and chemotherapy. However, chemotherapy still plays an important role in tumor
therapy. Due to the variety of pathogenic factors, the development process of tumors
is complex and regulated by many factors, and the treatment of a single drug is
easy to cause the human body to produce a drug-resistant phenotype to specific drugs
and eventually leads to treatment failure. In the process of clinical tumor treatment, the
combination of multiple drugs can produce stronger anti-tumor effects by regulating multiple
mechanisms and can reduce the problem of tumor drug resistance while reducing
the toxic side effects of drugs. Therefore, it is still a great challenge to construct an efficient
and accurate screening method that can systematically consider the synergistic anti-
tumor effects of multiple drugs. However, anti-tumor drug synergy prediction is of importance
in improving cancer treatment outcomes. However, identifying effective drug
combinations remains a complex and challenging task. This review provides a comprehensive
overview of cancer drug synergy therapy and the application of artificial intelligence
(AI) techniques in cancer drug synergy prediction. In addition, we discuss the
challenges and perspectives associated with deep learning approaches. In conclusion,
the review of the AI techniques' application in cancer drug synergy prediction can further
advance our understanding of cancer drug synergy and provide more effective treatment
plans and reasonable drug use strategies for clinical guidance.
Therapeutic Potential of Traditional Oriental Medicines in Targeting Tau Pathology: Insights from Cell-free and Cell-based Screening
Authors: Park Hyun Ha , Kim Byeong-Hyeon , Leem Seol Hwa , Park Yong Ho , Chung Hyunju , Yoo Doo-Han , Park Insu , Nam Yunkwon , Kim Sujin , Shin Soo Jung , Moon Minho 
Published: March 2024

Background:
Traditional Oriental Medicines (TOMs) formulated using a variety
of medicinal plants have a low risk of side effects. In previous studies, five TOMs,
namely Dangguijakyaksan, Hwanglyeonhaedoktang, Ukgansan, Palmijihwanghwan,
and Jowiseungchungtang have been commonly used to treat patients with Alzheimer’s
disease. However, only a few studies have investigated the effects of these five TOMs
on tau pathology.

Objective:
This study aimed to examine the effect of five TOMs on various tau pathologies,
including post-translational modifications, aggregation and deposition, tau-induced
neurotoxicity, and tau-induced neuroinflammation.

Methods:
Immunocytochemistry was used to investigate the hyperphosphorylation of
tau induced by okadaic acid. In addition, the thioflavin T assay was used to assess the effects
of the TOMs on the inhibition of tau K18 aggregation and the dissociation of tau
K18 aggregates. Moreover, a water-soluble tetrazolium-1 assay and a quantitative reverse
transcription polymerase chain reaction were used to evaluate the effects of the
TOMs on tau-induced neurotoxicity and inflammatory cytokines in HT22 and BV2
cells, respectively.

Results:
The five TOMs investigated in this study significantly reduced okadaic acid-induced
tau hyperphosphorylation. Hwanglyeonhaedoktang inhibited the aggregation of
tau and promoted the dissociation of tau aggregates. Dangguijakyaksan and Hwanglyeonhaedoktang
attenuated tau-induced neurotoxicity in HT22 cells. In addition, Dangguijakyaksan,
Hwanglyeonhaedoktang, Ukgansan, and Palmijihwanghwan reduced tauinduced
pro-inflammatory cytokine levels in BV2 cells.

Conclusion:
Our results suggest that five TOMs are potential therapeutic candidates for
tau pathology. In particular, Hwanglyeonhaedoktang showed the greatest efficacy
among the five TOMs in cell-free and cell-based screening approaches. These findings
suggest that Hwanglyeonhaedoktang is suitable for treating AD patients with tau pathology.

other:
.