bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishing Genetic and Molecular Markers of Sensitivity to a Novel and Potent Tetracyclic Terpenoid Therapy Against High-Grade Gliomas
Authors: Fontaine Dominique , Stathas SpiroAnthony , del Genio Carmen L. , Shentu Yujia , Nguyen Sidney , Zanazzi George , Chan Amy M. , Gaur Arti B. 
Published: March 2024

INTRODUCTION:
High-grade gliomas have the worst prognosis of all intracranial tumors, and therapeutic options are very limited. We have previously described a novel, highly selective and potent agonist of ERβ called ent-28 that inhibits the proliferation of patient-derived glioma cells in vitro. In addition, ent-28 significantly decreases the sizes of orthotopically implanted high-grade glioma patient-derived xenografts and induces apoptosis of tumor-derived cells with varying sensitivity.

METHODS:

ent-28 induced cell death of patient-derived tumor adherent- and stem-cells was analyzed in combination with the histopathologic, molecular, and genetic characteristics of each primary resected tumor for respective cell lines. GI50 values and apoptotic death induced by ent-28 were compared to IDH1 and ATRX mutational status as well as MGMT methylation.

RESULTS:
Compared to both untreated and control groups, ent-28-treated tumor-derived MGMT unmethylated cells demonstrated sensitivity. Additionally, tumor adherent cells underwent apoptosis at a higher rate compared to tumor stem cells.

CONCLUSIONS:
We have completed pre-clinical testing, safety, pharmacokinetics, metabolic stability, in vivo efficacy, and species rationalization for developing a novel compound, ent-28, as an anti-glioma therapy. To further enhance the efficacy of ent-28 against high-grade gliomas, we have used histopathologic characteristics of resected primary tumors to identify specific molecular and genetic markers that correlate to drug-sensitivity. Our findings suggest that specific molecular markers of sensitivity to ent-28 can be used to stratify response in patient derived cells, target tumor stem cells specifically, and further support the development of a potent therapy against high-grade gliomas.
Maximal Objectives in the Multiarmed Bandit with Applications
Authors: Ozbay Eren , Kamble Vijay 
Published: March 2024

In several applications of the stochastic multiarmed bandit problem, the traditional objective of maximizing the expected total reward can be inappropriate. In this paper, we study a new objective in the classic setup. Given K arms, instead of maximizing the expected total reward from T pulls (the traditional “sum” objective), we consider the vector of total rewards earned from each of the K arms at the end of T pulls and aim to maximize the expected highest total reward across arms (the “max” objective). For this objective, we show that any policy must incur an instance-dependent asymptotic regret of [Formula: see text] (with a higher instance-dependent constant compared with the traditional objective) and a worst case regret of [Formula: see text]. We then design an adaptive explore-then-commit policy featuring exploration based on appropriately tuned confidence bounds on the mean reward and an adaptive stopping criterion, which adapts to the problem difficulty and simultaneously achieves these bounds (up to logarithmic factors). We then generalize our algorithmic insights to the problem of maximizing the expected value of the average total reward of the top m arms with the highest total rewards. Our numerical experiments demonstrate the efficacy of our policies compared with several natural alternatives in practical parameter regimes. We discuss applications of these new objectives to the problem of conditioning an adequate supply of value-providing market entities (workers/sellers/service providers) in online platforms and marketplaces. This paper was accepted by Vivek Farias, data science. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.00801 .
Antibiotic overuse, poor antimicrobial stewardship, and low specificity of syndromic case management in a cross section of men with urethral discharge syndrome in Kampala, Uganda
Authors: Hamill Matthew M. , Onzia Annet , Parkes-Ratanshi Rosalind M. , Kyambadde Peter , Mande Emmanuel , Nakate Vivian , Melendez Johan H. , Gough Ethan , Manabe Yukari C. 
Published: March 2024

Objective
High prevalence of sexually transmitted infections (STIs) combined with poor antimicrobial stewardship are drivers of STI antimicrobial resistance (AMR) especially in resource-limited settings where syndromic case management (SCM) is the norm. We characterized patterns of antibiotic use prior to clinic attendance and study enrollment in Ugandan men with urethral discharge syndrome (UDS), evaluated in-clinic prescribing, and the performance characteristics of SCM.

Methods
Participants were recruited from government clinics participating in an existing gonococcal surveillance program in Kampala, Uganda. Questionnaires including antimicrobial use prior to attendance, prior episodes of UDS, penile swabs, and blood samples were collected. Bivariable and multivariable logistic regression models were used to estimate odds ratios (OR) for preselected factors likely to be associated with antibiotic use. In-clinic antibiotic treatment data were extracted from clinical notes, and the performance of SCM against laboratory-based STI diagnoses was evaluated.

Findings
Between October 2019 and November 2020, 100(40%) of 250 men with UDS reported taking antibiotics in the 14days prior to attending the clinic. Of these 210(84%) had at least one curable STI and 20% had a reactive point-of-care HIV test. Multivariable analysis demonstrated significant associations between recent antimicrobial use and duration of UDS symptoms <6 days (OR 2.98(95%CI 1.07,8.36), p = 0.038), and sex with women only (OR 0.08(95%CI 0.01,0.82),p = 0.038). The sensitivity of SCM ranged from 80.0% to 94.4%; specificity was low between 5.6% and 33.1%. The positive predictive value of SCM ranged from 2.4(95%CI 0.7,6.0) for trichomoniasis to 63.4(95%CI 56.5,69.9) for gonorrhea.

Conclusion
Pre-enrollment antibiotic use was common in this population at high risk of STI and HIV. Combined with the poor specificity of SCM for male UDS, extensive antibiotic use is a likely driver of STI-AMR in Ugandan men. Interventions to improve antimicrobial stewardship and deliver affordable diagnostics to augment SCM and decrease overtreatment of STI syndromes are required.
Care groups in an integrated nutrition education intervention improved infant growth among South Sudanese refugees in Uganda’s West Nile post-emergency settlements: A cluster randomized trial
Authors: Komakech Joel J. , Emerson Sam R. , Cole Ki L. , Walters Christine N. , Rakotomanana Hasina , Kabahenda Margaret K. , Hildebrand Deana A. , Stoecker Barbara J. 
Published: March 2024

Objective
This study examined the effects of a peer-led integrated nutrition education intervention with maternal social support using Care Groups on infant growth among South Sudanese refugees in Uganda.

Methods
A community-based cluster-randomized trial (RCT) was conducted among 390 pregnant women (third trimester). Two intervention study arms were Mothers-only(n = 131) and Parents-combined (n = 142) with a Control (n = 117). WHO infant growth standards defined length-for-age z-scores (LAZ) for stunting, weight-for-age z-scores (WAZ) for underweight and weight-for-length z-scores (WLZ) for wasting. The Medical Outcomes Study (MOS) social support index was a proxy measure for social support. A split-plot ANOVA tested the interaction effects of social support, intervention, and time on infant growth after adjusting for covariates. Further, pairwise comparisons explained mean differences in infant growth among the study arms.

Results
The mean infant birth weight was 3.1 ± 0.5 kg. Over the study period, infant stunting was most prevalent in the Control (≥ 14%) compared to Mothers-only (< 9.5%) and Parents-combined (< 7.4%) arms. There were significant interaction effects of the Care Group intervention and social support by time on infant mean LAZ (F (6, 560) = 28.91, p < 0.001), WAZ (F (5.8, 539.4) = 12.70, p = < 0.001) and WLZ (F (5.3, 492.5) = 3.38, p = 0.004). Simple main effects by the end of the study showed that the intervention improved infant mean LAZ (Mothers-only vs. Control (mean difference, MD) = 2.05, p < 0.001; Parents-combined vs. Control, MD = 2.00, p < 0.001) and WAZ (Mothers-only vs. Control, MD = 1.27, p < 0.001; Parents-combined vs. Control, MD = 1.28, p < 0.001).

Conclusion
Maternal social support with an integrated nutrition education intervention significantly improved infant stunting and underweight. Nutrition-sensitive approaches focused on reducing child undernutrition among post-emergency refugees may benefit from using Care Groups in programs.

Trial registration
Clinicaltrials.gov, NCT05584969.
Cost-effectiveness of one-year adjuvant trastuzumab therapy in treatment for early-stage breast cancer patients with HER2+ in Vietnam
Authors: Nguyen Anh Quynh , Tran Oanh Thi Mai , Nguyen Phuong Khanh , Nguyen Ha Thu 
Published: March 2024

Background
In Vietnam, trastuzumab is included in social health insurance’s benefits package with a reimbursement rate of 60%, but policymakers have been concerned about its cost-effectiveness. The research aims to evaluate the cost-effectiveness of one-year adjuvant trastuzumab therapy for early-stage breast cancer patients with human epidermal growth receptor 2 (HER2+) from a societal perspective.

Method
A Markov model was developed and validated to estimate the lifetime cost and effectiveness (using life year and quality-adjusted life year) of one-year adjuvant trastuzumab therapy compared to chemotherapy (using paclitaxel) alone. Treatment efficacy and transition probabilities were estimated based on published trials (i.e., N9831, NSABP B-31, HERA, and BCIRG 006). Local cost and utility data were employed to capture the Vietnam context. One-way sensitivity analysis, probabilistic sensitivity analysis, threshold, and scenario analysis were also performed.

Results
One-year adjuvant trastuzumab therapy combined with chemotherapy compared to chemotherapy alone yielded an additional cost of 888,453,971VND (39,062 US$) with an additional 3.09 LYs and 1.61 QALYs, resulting in an ICER of 287,390,682 VND (12,635 US$) per LY gained, or 519,616,972 VND (22,845 US$) per QALY gained. The ICER exceeds the cost-effective threshold of 1- and 3-time GDP per capita by 6.3 and 2.1 times. The probabilistic sensitivity analysis shows similar results. According to one-way sensitivity analysis, ICERs were driven mainly by transition probabilities and trastuzumab price. One-year adjuvant trastuzumab therapy would be cost-effective at the 3-time GDP per capita threshold if the cost of Herceptin 150mg and 450mg vials were reduced by 56% and 54%, correspondingly.

Conclusion
In Vietnam, one-year adjuvant trastuzumab therapy for early-stage breast cancer with HER2+ is not cost-effective. The research provided reliable and updated evidence to support policymakers in revising the health insurance benefit package. The policymakers should consider the options to reduce the cost of trastuzumab (e.g., regarding the use of trastuzumab biosimilars, price negotiation options, and options of optimizing the use of Herceptin vials among concurrent hospitalized breast cancer patients).
Wholesale Couture: London and Beyond, 1930–1970, Liz Tregenza (2023)
Authors: Cook Jennie 
Published: March 2024

Review of: Wholesale Couture: London and Beyond, 1930–1970, Liz Tregenza (2023)
London: Bloomsbury Publishing, 236 pp.,
ISBN 978-1-35024-586-0, h/bk, $115.00
AI and access to justice: How AI legal advisors can reduce economic and shame-based barriers to justice
Authors: Long Brandon , Palmer Amitabha 
Published: March 2024

ChatGPT – a large language model – recently passed the U.S. bar exam. The startling rise and power of generative artificial intelligence (AI) systems such as ChatGPT lead us to consider whether and how more specialized systems could be used to overcome existing barriers to the legal system. Such systems could be employed in either of the two major stages of the pursuit of justice: preliminary information gathering and formal engagement with the state’s legal institutions and professionals. We focus on the former and argue that developing and deploying publicly funded AI legal advisors can reduce economic and shame-based cultural barriers to the information-gathering stage of pursuing justice.
Repassivation characteristics of carbon steel in chloride-free pore solution after thermal cycles of simulated tropical marine environments
Authors: Wu Tong , Feng Xingguo , Lu Xiangyu , Zhuang Ning , Qu Shuai 
Published: March 2024

Abstract
Repassivation characteristics of carbon steel experienced thermal cycles in tropical marine environments were investigated in a simulated concrete pore solution (SCPS). The results suggested that the damage of passive films on the carbon steel mainly occurred during the cooling process in thermal cycles. The damaged passive films gradually recovered in the SCPS, and the duration of repassivation extended with the amplitude of thermal cycles and cyclic number in the high-amplitude thermal cycles (20–60 °C and 20–70 °C), while it was not significantly affected by the cyclic number in the low-amplitude thermal cycles (20–40 °C and 20–50 °C).
Evaluation of Viaducts’ contribution to road network accessibility in the Yunnan–Guizhou area based on the node deletion method
Authors: Wang Zichen , Cheng Changxiu , Guo Lanlan , Liu Shan 
Published: March 2024

Abstract
It is necessary to evaluate the construction effect of viaducts and identify the viaducts that play a key role in road networks. Based on the node deletion method, this article proposes a method to identify the importance of viaducts in road networks. After applying this method to simulate the importance of viaducts in the highway networks in Yunnan and Guizhou Provinces from 2001 to 2020, the results show the following: (1) The viaducts with high importance were mainly built in 2002, 2009, 2015, and 2016. They are mainly distributed on expressways such as the HUKUN Expressway, HANGRUI Expressway, and YINBAI Expressway. Among the viaducts, the Mengzhai Bridge and Beipanjiang Bridge Hukun are the most important. (2) The importance of viaducts will increase, decrease, or increase first and then decrease. Among the years studied, 2012 and 2016 are important time nodes for change. The trend of changes is affected by the construction of highways and viaducts in other locations. In this road network, there are strong coupling relationships between nodes. (3) The importance of some viaducts is not prominent in the whole region, but that does not mean their construction value is low. They may have a high connectivity effect on specific regions from a local perspective.
Research on the construction and reform path of online and offline mixed English teaching model in the internet era
Authors: Lan Ying 
Published: March 2024

Abstract
The Internet era resulted in the rise and advancement of MOOK, WeChat, and mobile networks, making it possible to expand English teaching methods. However, the English teaching industry has the problem of not valuing students’ personalized cognition, and the accuracy of teaching resource delivery is low. Therefore, the research uses the noise gate analysis method to design a cognitive diagnostic model for students and designs an English teaching resource recommendation model in view of a convolutional joint probability matrix (JPM) decomposition algorithm. The research results showed that the cognitive diagnostic model designed in the study had a higher accuracy. Compared to traditional algorithms, the overall recommendation effect of the English teaching resource recommendation model had an average improvement of 11.63% and compared to the JPM algorithm combined with cognitive diagnosis (CD), the overall recommendation effect value had an average improvement of 1.977%. When recommending complex teaching resources, the recommendation effect value had an average improvement of 11.54% compared to traditional algorithms, and the overall average improvement was 1.877% compared to the JPM algorithm combined with CD. In the experimental group, with the assistance of the research algorithm, students’ grades improved by an average of 2.38 points, which was significantly higher than the 0.89 points in the control group. The experiment showcases that the CD and recommendation model designed by the research has higher accuracy, can help improve the efficiency of teaching resource recommendation, reduces teaching costs, and has certain application value.
Five-Week, Low-Intensity Blood Flow Restriction Rowing Improves V̇o 2max in Elite Rowers
Authors: Held Steffen , Rappelt Ludwig , Rein Robert , Deutsch Jan-Philip , Wiedenmann Tim , Donath Lars 
Published: March 2024

Abstract
Held, S, Rappelt, L, Rein, R, Deutsch, J-P, Wiedenmann, T, and Donath, L. Five-week, low-intensity, blood flow restriction rowing improves V̇o
2max in elite Rowers. J Strength Cond Res XX(X): 000–000, 2024—This controlled intervention study examined the effects of low-intensity rowing with blood flow restriction (BFR) on maximal oxygen uptake (V̇o
2max), peak power output during ramp testing (PPO), and 2000-m time trial performance (P2k). Eleven, highly elite, male rowers (22.1 ± 1.6 years; 92.6 ± 3.8 kg; 1.93 ± 0.04 m; 7.9. ± 2.2 years rowing experience; 20.4 ± 2.0 h·w−1 training volume; 11.9 ± 1.1 session per week) trained 5 weeks without BFR (Base) followed by a 5-week BFR intervention period. BFR of the lower limb was applied through customized elastic wraps. BFR took place 3 times a week (accumulated net pBFR: 60 min·wk−1; occlusion per session: 2 times 10 min·session−1) and was used exclusively at low intensities (<2 mmol·L−1). V̇o
2max, PPO, and P2k were examined before, between, and after both intervention periods. Bayesian’s credible intervals revealed relevantly increased V̇o
2max +0.30 L·min−1 (95% credible interval: +0.00 to +0.61 L·min−1) adaptations through BFR. By contrast, PPO +14 W (−6 to +34 W) and P2k −5 W (−14 to +3 W) were not noticeably affected by the BFR intervention. This study revealed that 15 sessions of BFR application with a cumulative total BFR load of 5 h over a 5-week macrocycle increased V̇o
2max remarkably. Thus, pBFR might serve as a promising tool to improve aerobic capacity in highly trained elite rowers.
A MÍTICA DO JUIZ HÉRCULES NA RESOLUÇÃO DE HARD CASES: UM ESTUDO DO JULGAMENTO DO TEMA 786 DO STF
Authors: Vieira Lopes Tailane 
Published: March 2024

O presente ensaio se propõe a analisar a decisão proferida pelo Supremo Tribunal Federal no âmbito do Recurso Extraordinário nº 1010606 - RJ, que deu origem ao Tema 786, afetado com repercussão geral, sob a óptica da mítica do juiz Hércules, construída Ronald Dworkin. A tese fixada pelos ministros estabeleceu que é incompatível com a Constituição a ideia de um direito ao esquecimento, tendo em vista que esta é conflitiva com o direito fundamental da liberdade de expressão e de informação. Tratando de caso difícil, em que fora analisada a possibilidade de o exercício da liberdade de expressão, eventualmente, colidir com outros direitos fundamentais, a exemplo da proteção à honra, à imagem e à privacidade, o objetivo desse estudo é verificar se no exercício da atuação jurisdicional do STF, diante de um hard case, foram adotados os parâmetros estabelecidos por Dworkin para auxiliar a atuação dos juízes na resolução de conflitos em que não há uma previsão expressa de regra jurídica para a sua solução.
Pemberdayaan Kelompok Tani Kopi Robusta di Desa Amadanom Kecamatan Dampit Berbasis Teknologi untuk Peningkatan Kualitas Hasil Panen
Authors: Agustino Hutri , Prakoso Havidz Ageng , Zahidi M. Syaprin 
Published: March 2024

Desa Amadanom yang terletak di Kecamatan Dampit sudah lama dikenal sebagai salah satu wilayah penghasil kopi khususnya jenis robusta di wilayah Selatan Kabupaten Malang Propinsi Jawa Timur. Wilayah tersebut menjadi bagian dari branding kopi yang populer dengan akronim AMSTIRDAM (Ampel Gading, Sumbermanjing, Tirtoyudo dan Dampit). Produk kopi dari wilayah AMSTIRDAM tersebut sudah tersebar di berbagai wilayah bahkan sampai mancanegara. Mengingat, cita rasanya yang khas dari daerah pegunungan tropis. Maka, tidak mengherankan jika industri kopi di wilayah tersebut mampu bertahan setidak-tidaknya sampai empat generasi dengan berbagai tantangan yang dihadapinya. Salah satu dari kendala yang masih dihadapi oleh kelompok tani kopi di Desa Amadanom adalah terkait dengan adopsi teknologi, khususnya yang berkaitan dengan pengolahan hasil panen untuk peningkatan kualitas kopi yang dihasilkan. Tidak dapat dipungkiri bahwa fokus dari industri perkebunan kopi tidak hanya berkaitan dengan peningkatan produktivitas (volume) hasil panen, tetapi juga peningkatan kualitas kopi yang dihasilkan. Ini menjadi faktor yang tidak bisa di tinggalkan, karena kualitas produk menjadi acuan utama bagi customer dalam menentukan varian pilihan yang tersebar di pasaran. Artinya bahwa antara sisi kuantitas dan kualitas menjadi dua hal yang tidak dapat dipisahkan, di satu sisi volume hasil panen harus mampu menjaga stabilitas kebutuhan produk, tetapi di sisi lain bahwa kualitas produk tidak boleh terabaikan hanya karena mengejar volume permintaan pasar. Oleh sebab itu, kegiatan pengabdian ini di fokuskan pada upaya peningkatan kualitas hasil panen berbasis teknologi pengupas kulit kopi. Mengingat, sampai saat kelompok tani kopi di wilayah tersebut masih menggunakan cara manual yang membuat prosesnya menjadi lebih lama dan cukup melelahkan dan berpengaruh pada kualitas produk yang dihasilkan karena berpotensi merusak tekstur biji kopi tersebut. Pengadaan alat pengupas kulit kopi tersebut telah disertai dengan transfer of technology kepada kelompok tani kopi robusta di wilayah pengabdian. Adapun metode yang digunakan adalah sebagai berikut: (a). Penyuluhan tentang strategi peningkatan kualitas komoditas kopi robusta; (b). Pelatihan transfer of technology alat pengupas kulit kopi; dan (c) Diskusi evaluasi dari hasil penyuluhan dan pelatihan yang telah dilakukan sebagai bahan rekomendasi untuk kegiatan pengabdian pada tahun berikutnya.
Pemanfaatan Pellet Limbah Kayu untuk Pengasapan Ikan pada Kelompok Pengolah Ikan di Wonosari, Kabupaten Demak
Authors: Subekti Niken , Maulana Sonika , Rifa’atunnisa Rifa’atunnisa , Findayani Aprilia , Rozi Fahrur , Milano Roderikus Rayditya 
Published: March 2024

Kesadaran masyarakat pengolah ikan di Wonosari, Kabupaten Demak meningkatkan kualitas dan pendapatan dalam mengelola ikan hasil tangkapan nelayan. Berkembangnya kesadaran masyarakat terhadap bahaya pestisida sebagai bahan pengawet menyebabkan tuntutan masyarakat yang menginginkan bahan pengawet yang ramah lingkungan. Kondisi ini memberikan peluang untuk mengembangkan dan memproduksi pellet limbah kayu. Program pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pendapatan pengolah ikan, meningkatkan kualitas ikan asap dan efisiensi energi, karena pellet lebih hemat biaya, nyaman, bersih, sehat, dan aman untuk dikonsumsi, jika dibandingkan dengan bahan bakar kayu biasa. Ikan asap menjadi lebih tahan terhadap kerusakan oleh organisme perusak (bakteri dan jamur). Metode yang digunakan adalah aplikasi prototipe pembuatan pellet limbah kayu skala pilot plan untuk meningkatkan produksi bahan bakar alami dan aman untuk dikonsumsi, sehingga siap dikomersilkan. Kegiatan pengabdian masyarakat ini akan menghasilkan bahan bakar pellet limbah kayu dengan mutu yang konsisten, kapasitas produksi meningkat dan meningkatkan efisiensi bahan bakar untuk pengasapan ikan.