bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-reported concussion history is not related to cortical volume in college athletes
Authors: Schultz Douglas H. , Bouchard Heather C. , Barbot Michelle C. , Laing-Young Julia M. , Chiao Amanda , Higgins Kate L. , Savage Cary R. , Neta Maital 
Published: April 2024

AbstractThe long-term consequences of concussion are still being uncovered but have been linked to disruptions in cognition and psychological well-being. Previous studies focusing on the association between concussion history and structural changes in the brain have reported inconsistent results. We sought to examine the effect of concussion history on cortical volume with a focus on functional networks. These networks are associated with many of the functions that can be disrupted in those with an extensive concussion history. Collegiate athletes (n=296) in the present study who self-reported concussion history did not report different baseline symptoms and did not exhibit consistent differences in cognitive performance relative to those who reported no concussion history. We found that concussion history was not related to cortical volume at the network or region level, even when we compared participants with two or more concussions to those with no concussion history. We did identify relationships between cortical volume in the visual network and dorsal attention network with cognitive performance. In addition to comparing cortical volume between individuals with and without reported concussion history, we also examined whether cortical volume changes could be observed within individuals from baseline to acutely following concussion. We found that network level cortical volume did not change within subjects from baseline measurement to acutely post-concussion. Together, these results suggest that both self-reported concussion history and acute concussion effects are not associated with changes in cortical volume in young adult athletes.
SP110 sequestration of SP100 protects against toxic filaments during innate immune signaling
Authors: Aird Eric J. , Rabl Julius , Knuesel Tabea , Scherpe Lynn , Boehringer Daniel , Corn Jacob E. 
Published: April 2024

AbstractStimulation of the innate immune system by foreign RNA elicits a potent response against invading pathogens and can trigger cell death. The mechanisms by which cells balance a robust response with cell-intrinsic lethality are still being uncovered. Employing genome-wide CRISPR-Cas9 genetic screens with triphosphorylated RNA stimulation, we identify speckled protein 110 (SP110) as a potent negative regulator of type 1 interferon-driven cell death. Death suppression by SP110 counteracts a death-promoting activity of another speckled protein, SP100. Both SP110 suppression and SP100 toxicity are mediated by direct interactions between the caspase activation and recruitment domains (CARDs) in each protein. SP100-induced death is mediated by homomeric CARD filaments that are disassembled by a heteromeric CARD interaction with SP110. Overexpression of SP100 is sufficient to overwhelm normal levels of SP110, leading to genotoxicity. Using cryo-EM and AlphaFold modeling, we develop and validate an atomic description of SP100 CARD filament formation and filament breaking by SP110. Genome-wide binding studies reveal that SP110 and SP100 normally associate at active promoters, but disruption of the CARD interaction releases SP100 to form toxic filaments. Overall, we uncover a novel regulatory partnership in human innate immunity that balances signal potency with cell intrinsic lethality.
A robust platform for BaEVRless-lentiviral synthesis and primary natural killer cell transduction
Authors: Lan Yi-Jun , Nguyen Quoc Viet , Chao Tsu-Lan , Yeh Kuo-Lun , Lin Steven 
Published: April 2024

AbstractLentiviral vectors are invaluable tools for genetic modification in human cells for research, biotechnological and clinical applications. However, certain cell types, such as primary human natural killer (NK) cells, present challenges in lentiviral transduction. Overcoming this limitation requires specific pseudotype modifications. BaEVRless-pseudotyped lentivirus (BaEVRless-LV) has shown promise in efficiently transducing human NK cells, B cells, and hematopoietic stem cells (HSCs). BaEVRless, a modified envelope protein derived from Baboon endogenous retrovirus, targets ASCT receptors in human cells. While effective for several immune cell types, BaEVRless-LV production in standard HEK293T cells is challenging. During lentiviral synthesis, BaEVRless protein induces hyper cell fusion, leading to rapid HEK293T cell death and reduced BaEVRless-LV titers. To solve this problem, we used CRISPR genome editing to knockout (KO) theASCT2gene in HEK293T cells, thereby abolishing BaEVRless-induced cell fusion. Using theASCT2-KO cells and an optimized viral production protocol, we efficiently packaged high titers of BaEVRless-LV encoding various transgenes, includingturbogfp, chimeric antigen receptor (CAR), and a pooled CRISPR sgRNA library. Our robust BaEVRless-LV synthesis platform is readily adaptable for manufacturing cell therapeutics and enables advanced research techniques such as CRISPR genetic screens in primary NK cells.
The impact of cooking and burial on proteins: a characterisation of experimental foodcrusts and ceramics
Authors: Evans Miranda , Hagan Richard , Boyd Oliver , Bondetti Manon , Craig Oliver , Collins Matthew , Hendy Jessica 
Published: April 2024

AbstractFoodcrusts have received relatively little attention in the burgeoning field of proteomic analysis of ancient cuisine. We remain ignorant of how cooking and burial impacts protein survival, and crucially, the extent to which the extractome reflects the composition of input ingredients. Therefore, through experimental analogues we explore the extent of protein survival in unburied and buried foodcrusts and ceramics using ‘typical’ Mesolithic ingredients (red deer, Atlantic salmon and sweet chestnut). We then explore a number of physiochemical properties theorised to aid protein preservation. The results reveal that proteins were much more likely to be detected in foodcrusts than ceramics using the methodology employed, input ingredient strongly influences protein preservation, and that degradation is not universal nor linear between proteins, indicating that multiple protein physiochemical properties are at play. While certain properties such as hydrophobicity apparently aid protein preservation, none single-handedly explain why particular proteins/peptides survive in buried foodcrusts: this complex interplay requires further investigation. The findings demonstrate that proteins indicative of the input ingredient can be identifiable in foodcrust, but that the full proteome is unlikely to preserve. While this shows promise for the survival of proteins in archaeological foodcrust, further research is needed to accurately interpret foodcrust extractomes.
Understanding the biosynthesis, metabolic regulation, and anti-phytopathogen activity of 3,7-dihydroxytropolone inPseudomonasspp
Authors: Moffat Alaster D. , Höing Lars , Santos-Aberturas Javier , Markwalder Tim , Malone Jacob G. , Teufel Robin , Truman Andrew W. 
Published: April 2024

ABSTRACTThe genusPseudomonasis a prolific source of specialized metabolites with significant biological activities, including siderophores, antibiotics, and plant hormones. These molecules play pivotal roles in environmental interactions, influencing pathogenicity, inhibiting microorganisms, responding to nutrient limitation and abiotic challenges, and regulating plant growth. These properties mean that pseudomonads are candidates as biological control agents against plant pathogens. Multiple transposon-based screens have identified aPseudomonasbiosynthetic gene cluster (BGC) associated with potent antibacterial and antifungal activity that produces 7-hydroxytropolone (7-HT). In this study, we show that this BGC also makes 3,7-dihydroxytropolone (3,7-dHT), which has strong antimicrobial activity towardsStreptomyces scabies, a potato pathogen. Both molecules exhibit broad biological activities, suggesting roles in competitive soil and plant microbial communities. Through metabolomics and reporter assays, we unveil the involvement of cluster-situated genes in generating phenylacetyl-coenzyme A, a key precursor for tropolone biosynthesis via the phenylacetic acid catabolon. The clustering of these phenylacetic acid genes within tropolone BGCs is unusual in other Gram-negative bacteria. Our findings support the interception of phenylacetic acid catabolism via an enoyl-CoA dehydratase encoded in the BGC, as well as highlighting an essential biosynthetic role for a conserved thioesterase. Biochemical assays were used to show that this thioesterase functions after a dehydrogenation-epoxidation step catalysed by a flavoprotein. We use this information to identify diverse uncharacterised BGCs that encode proteins with homology to flavoproteins and thioesterases involved in tropolone biosynthesis. This study provides insights into tropolone biosynthesis inPseudomonas, laying the foundation for further investigations into the ecological role of tropolone production.
B→D*ℓνℓ
semileptonic form factors from lattice QCD with Möbius domain-wall quarks
Authors: Aoki Y. , Colquhoun B. , Fukaya H. , Hashimoto S. , Kaneko T. , Kellermann R. , Koponen J. , Kou E. ,   JLQCD Collaboration
Published: April 2024

We calculate the form factors for the B→D*ℓνℓ decay in 2+1 flavor lattice QCD. For all quark flavors, we employ the Möbius domain-wall action, which preserves chiral symmetry to a good precision. Our gauge ensembles are generated at three lattice cutoffs a−1∼2.5, 3.6, and 4.5 GeV with pion masses as low as Mπ∼230  MeV. The physical lattice size L satisfies the condition MπL≥4 to control finite volume effects (FVEs), while we simulate a smaller size at the smallest Mπ to directly examine FVEs. The bottom quark masses are chosen in a range from the physical charm quark mass to 0.7a−1 to control discretization effects. We extrapolate the form factors to the continuum limit and physical quark masses based on heavy meson chiral perturbation theory at next-to-leading order. Then the recoil parameter dependence is parametrized using a model independent form leading to our estimate of the decay rate ratio between the tau (ℓ=τ) and light lepton (ℓ=e, μ) channels R(D*)=0.252(22) in the Standard Model. A simultaneous fit with recent data from the Belle experiment yields |Vcb|=39.19(91)×10−3, which is consistent with previous exclusive determinations, and shows good consistency in the kinematical distribution of the differential decay rate between the lattice and experimental data.

Published by the American Physical Society
2024
Why might home-based work duties be perceived by female academics as extreme? A qualitative study
Authors: Mousa Mohamed , Avolio Beatrice 
Published: April 2024

PurposeThis study aims to answer the following question: Why might home-based work duties be perceived by female academics as extreme?Design/methodology/approachWe employed a qualitative research method through semi-structured interviews with 33 female academics from three public universities selected from amongst 26 public institutions of higher education in Egypt. Thematic analysis was subsequently used to determine the main ideas in the transcripts.FindingsWe find that the sudden implementation of home-based work makes the academic duties of female academics extreme. Moreover, the following four factors help explain the extremity/intensity of the home-based work of female academics: mental and physical fatigue resulting from WFH, the inability to adequately meet family commitments when working from home (WFH), poor resources for home-based work and reduced ability to focus on the obstacles facing them in their academic career.Originality/valueThis paper contributes by filling a gap in human resources management and higher education in which empirical studies on female academics WFH and extreme academic duties have been limited so far.
How social media marketing activities affect brand loyalty? Mediating role of brand experience
Authors: Kumar Sushant , Hsieh Jung-Kuei 
Published: April 2024

PurposeIncreasingly brands are performing several activities on social media in order to alter consumer consumption towards their offering. However, limited studies have attempted to understand as how activities on social media influence usage intentions and brand loyalty. Thus, this study aims to examine the influence of social media marketing activities (SMMA) on brand experience and its association with continued usage intentions (CUI) and brand loyalty.Design/methodology/approachThe study conceptualized a research model by using the theoretical premise of stimulus-organism-response theory. SMMA acts as stimulus, four (sensory, affective, behavioral and intellectual) elements of brand experience act as organism, and CUI and brand loyalty act as response. A survey-based questionnaire is used to collect data from 309 respondents. The hypothesized associations of research model were examined using the structural equation modeling approach.FindingsResults of the study are in line with hypothesized associations among constructs. Results suggest that SMMA is associated with all four elements of brand experience. Also, affective, behavioral and intellectual aspects of brand experience are associated with CUI which influence brand loyalty. The moderating role of education on hypothesized association and the mediating role of organism are also confirmed.Originality/valueUsing stimulus-organism-response theory, this study confirms that SMMA are associated with sensory, affective, behavioral and intellectual aspect of brand experience which has not been examined so far. Also, the novel findings of study add to existing literature of SMMA, brand experience and brand loyalty. The study further contributes to literature by showing the moderation effect of education.
Optimising construction waste management in Sri Lanka through Circular economy strategies: a focus on construction and renovation and use and operate stages
Authors: Victar Hasith Chathuranga , Waidyasekara Anuradha Samarajeewa 
Published: April 2024

PurposeConstruction and Demolition (C&D) Waste Management (WM) poses significant challenges in Sri Lanka, contributing to environmental degradation and resource depletion. To address these issues, this study explores the application of Circular Economy (CE) strategies in minimising waste generation and optimising resource utilisation in Sri Lankan construction industry. The research focuses on the construction and building renovation and use and operate stages of the building project life cycle, recognising their significance in waste generation and resource consumption.Design/methodology/approachThe research employed a qualitative approach, utilising the Delphi technique through three rounds of expert interviews. Seventeen experts were involved in the first round, followed by fifteen in the second round, and twelve in the final round. The collected data was analysed using manual content analysis methods.FindingsThe research findings revealed fifteen C&D WM issues in the construction and building renovation stage in Sri Lanka, along with suitable strategies to overcome each of them. Similarly, eight C&D WM issues were identified for the use and operate stage of the building, and corresponding strategies were provided to address each issue. By adopting CE strategies such as modular design and material reuse, construction projects can optimise the project's timeline, cost, and quality factors. These strategies enable efficient resource allocation, reduce waste generation, and contribute to the overall sustainability of the project. The impact of CE strategies on mitigating these issues within the project management iron triangle was also discussed.Originality/valueThis paper entails delving into how construction, building renovation, and operation stages of a building's life cycle intersect with CE strategies, which profoundly influence operational efficiency and long-term sustainability. By incorporating principles such as energy efficiency, water conservation, and circular product design, the paper illuminates how these strategies facilitate decreased energy usage, enhanced resource management, and diminished waste production throughout the building's lifespan.
Social enterprise governance and labor equity: the emerging role of work-integrated social enterprises in a niche labor market
Authors: Lee Misun , Brower Ralph S. , Fay Daniel L. 
Published: April 2024

PurposeThis paper analyzes how a national social enterprise policy encourages the social missions of social enterprises and uncovers the relationships between social enterprise governance and labor equity, an area that has been rarely studied in nonprofit governance studies.Design/methodology/approachThe study analyzes the effects of four legal requirements for work-integrated social enterprises (WISEs) codified by the Social Enterprises Promotion Act (SEPA, 2007) in South Korea. Then, it relies on panel regression analysis (2020–2022) to examine how the compositions of the governance of WISEs are related to their hiring and wage equity.FindingsThe institutional arrangements required by SEPA have resulted in positive social impacts for most WISEs. However, the results of regression models show that individual participant groups in the WISE governance achieved mixed results depending on the labor issue.Research limitations/implicationsGenerally, this research explores the concept of diversity and its utility in nonprofit governance, with a particular focus on targeted diversity policies, demonstrating that governance arrangements influence the success of these policies.Practical implicationsThe findings bring new insights for policymakers about “altruistic economic entities.” For practitioners in social enterprises, the results of the regression models underscore the importance of understanding the participant composition of decision-making meetings.Originality/valueThis study sheds light on labor equity, which government-certified social enterprises should achieve from the perspective of nonprofit governance.
Financial technology and economic growth nexus in the East African community states
Authors: Ngong Chi Aloysius , Thaddeus Kesuh Jude , Onwumere Josaphat Uchechukwu Joe 
Published: April 2024

PurposeThis paper aims to examine the causation linking financial technology to economic growth in the East African Community states from 1997 to 2019.Design/methodology/approachAutoregressive distributed lag is used. Gross domestic product per capita proxies economic growth, automated teller machines, point of sale, debit card ownership and mobile banking measure financial technology.FindingsThe results unveil a significant relationship between financial technology and economic growth. The findings show bidirectional causality between automated teller machine and economic growth, with unidirectional causation from economic growth to point of sales and internet banking, mobile banking and government effectiveness to economic growth. The error correction term is negatively significant, demonstrating a long-term convergence between Fintech measures and economic growth.Research limitations/implicationsThe governments should effectively enact and implement policies that protect investments in financial technologies to boost economic growth in the East African Community countries. The government should reduce taxes on financial technology equipment and related services. The use of automated teller machine, debit card ownership and internet banking should be encouraged through cashless transactions. Financial institutions should adopt cashless operation policies to encourage the use of financial technologies.Originality/valueResearch results on the bond between financial technology and economic growth are not conclusive. These studies demonstrate that technological innovations are double edged-swords, with both positive and negative sides. The results are conflicting; some reveal positive relationships, while others show negative links. Hence, research is required to fill the lacuna.
The mediating role of marketing management in the relationship between online presence and product innovation among SMEs
Authors: Pérez-Orozco Allan , Leiva Juan Carlos , Mora-Esquivel Ronald 
Published: April 2024

PurposeThis study explores the mediating role of marketing management in the relationship between online presence and product innovation among Small and Medium Enterprises (SMEs).Design/methodology/approachThe sample comprises 205 Costa Rican SMEs collected by the Global Competitiveness Project during the first half of 2019. The data were analyzed using a two-stage modeling strategy for ordinary regression models to analyze mediation effects.FindingsMarketing management as a strategic resource or capability accounts for the relationship between online presence and product innovation performance in SMEs, meaning that online presence resources require complementary organizational capabilities in marketing management to enhance product innovation.Originality/valueThis study, grounded in the resource-based view theory, contributes to the innovation field by identifying marketing management capabilities as an intermediate strategic interaction between online presence and product innovation performance in SMEs. Thus, managers should recognize the advantages of integrating marketing management principles and tactics into online presence tools to realize the value of their products by tailoring them to their client’s needs.
Open innovation and new product development: major themes and research trajectories
Authors: Rautela Sonica 
Published: April 2024

Purpose
This paper aims to review the extant literature on open innovation and new product development (NPD) using bibliometric analysis to gauge the evolving journey of this concept in the domain of Business and Management.

Design/methodology/approach
The researcher used the Scopus database to search the relevant documents for bibliometric analysis. The data range was from 2006 till June 2023. Citation analysis, co-citation analysis and co-occurrence of authors' keywords were used for bibliometric analysis.

Findings
The paper charts the intellectual structure of literature related to open innovation and NPD. The five major themes emerge as prominent themes in the literature, i.e. Open Innovation: Conceptualization, Dynamic Capabilities and Competitive Advantages; Open Innovation: Contingencies and Possibilities; Co-creation and New Product Development (NPD); Open Innovation for Businesses: A Shifting Paradigm; and Implementing of Open Innovation in Industries: Cases. Besides this, the study also reveals the most influential authors, journals and countries in their contribution to open innovation and new product development. Future research directions are also presented.

Practical implications
The present study contributes on academic and managerial fronts. The study provides important insights contributing to the open innovation and NPD literature. From the organizational point of view, the study provides a detailed understanding of the concept of open innovation and NPD that can aid managers in acquiring a comprehensive knowledge of the concept before using it as a strategic intervention.

Originality/value
The present study identifies the gradual progression of this research area over time. It delineates key themes emerging from past literature, providing avenues for future research.