bluuebunny/crossref_metadata_2025_split huggingface dataset:
Search for Evidence-Based Approaches for the Prevention and Palliation of Hand–Foot Skin Reaction (HFSR) Caused by the Multikinase Inhibitors (MKIs)
Authors: Anderson Roger , Jatoi Aminah , Robert Caroline , Wood Laura S. , Keating Karen N. , Lacouture Mario E. 
Published: March 2009

Abstract

Background.
The anticancer multikinase inhibitors (MKIs) are associated with cutaneous adverse events, including hand–foot skin reaction (HFSR), a condition affecting 20%–40% of patients. Symptoms are usually mild, but can evolve into a painful condition that limits function and impacts quality of life (QoL), resulting in shortened cancer treatment duration or intensity. The goal of this study was to systematically review the literature on the prevention and palliation of MKI-associated HFSR, to identify areas for further clinical study, and to provide a foundation for evidence-based guidelines for HFSR management.

Methods.
Systematic searches of the National Library of Medicine’s PubMed database, Cochrane Reviews, BIOSIS, CancerLit, and the American Society of Clinical Oncology website were conducted using search terms for cutaneous toxicities associated with chemotherapeutic agents. Articles were categorized (C) based on type of agent and cutaneous reaction as: C1 (MKI and HFSR); C2 (MKI and other cutaneous toxicity); C3 (other antineoplastic agents and HFSR); and C4, other.

Results.
Of the 2,069 abstracts screened, 350 (17%) met the criteria for C1–C4, with 56 (16%) coded as C1 with details of HFSR histology, pathogenesis, clinical outcome, QoL impact, and/or prevention and treatment approaches in MKI-treated patients. No randomized, controlled trials (RCTs) on prevention/palliation of HFSR were identified. Anecdotal evidence or expert opinion advocated protective measures, preventive and therapeutic skin care, systemic analgesics for pain, vitamin B6, and MKI dose modification.

Conclusion.
No articles containing evidence from RCTs on preventive/palliative approaches to MKI-associated HFSR have been published. Systematic study of optimal treatment strategies for HFSR is needed to advance development of evidence-based treatment guidelines.
Ti-in-biotite geothermometry in non-graphitic, peraluminous metapelites from Crni vrh and Resavski humovi (Central Serbia)
Authors: Erić Suzana , Logar Mihovil , Milovanović Dragan , Babič Danilo , Adnađević Borivoj 
Published: March 2009

Ti-in-biotite geothermometry in non-graphitic, peraluminous metapelites from Crni vrh and Resavski humovi (Central Serbia)The study discusses the application of the Ti-in-biotite geothermometer of Henry et al. (2005) to the example of biotites from non-graphitic peraluminous micaschists of Central Serbia. Three petrographically different micaschists were distinguished on the basis of the following mineral assemblages: CV1 (St-Grt-Bt-Ms-Pg-Pl-Qtz), CV2 (Grt-St-Ky-Bt-Ms-Pl-Qtz) and RH (Grt-St-Bt-Ms-Pl-Qtz). Applying different geothermobarometers it was estimated that the studied micaschists were metamorphosed at average temperatures and pressures of 530 °C and 520 MPa (CV1incl), 580 °C and 670 MPa (CV1), 630 °C and 700 MPa (CV2) and 550 °C, 680 MPa (RH). The average temperatures obtained by the Ti-in-biotite method revealed uniform values for CV1 and CV2 micaschists and these values are very similar to the temperatures obtained by other methods. In contrast, the application of Ti-in-biotite geothermometer for RH micaschist yields the temperature difference of 85-110 °C. The variability of temperature is interpreted as a result of a positive correlation of Ti contents and XMgvalues in RH biotite, which is in disagreement with the principles of the Ti-in-biotite method. The positive Ti-XMgcorrelation is a result of the compositional variability shown by RH biotites from different samples, which can possibly be related to compositional inhomogeneities of the pelitic protolith. On the other hand, the Ti-in-biotite geothermometer for CV2 biotite gave very uniform temperatures despite variable Ti contents (Ti = 0.260, sd = 0.018 apfu). This is explained as result of the low sensitivity of Ti-in-biotite geothermometer for high Ti concentrations (> 0.25 apfu).
Precepting in the Fast Lane: Improving Critical Thinking in New Graduate Nurses
Authors: Sorensen Heather A. J. , Yankech L. Rose 
Published: March 2009

Background:
Research regarding the relationship between preceptorship and development of critical thinking in new graduate nurses is sparse. No studies could be found that examined the relationship of preceptor education to critical thinking scores of new graduate nurses.

Methods:
A quasi-experimental, mixed-methods design measured critical thinking ability of new graduate nurses. Focus group interviews were conducted with preceptors who attended an author-developed educational program.

Results:

Preceptors' participation in the educational session contributed to the evaluation subscale of critical thinking skills of the experimental group on the California Critical Thinking Skills Test (
F
= 4.709,
p
= .039). Preceptors had positive qualitative responses.

Conclusions:
Critical thinking skills of new graduate nurses can be improved and learning relationships developed through preceptor education. Further study is suggested.

J Contin Educ Nurs
2008;39(5):208–216.
Exploring How New Registered Nurses Construct Professional Identity in Hospital Settings
Authors: Deppoliti Denise 
Published: March 2009

Purpose:
To describe and explore the experiences that contribute to the construction of professional identity in hospital nurses 1 to 3 years postgraduation from nursing school.

Methodology:
This qualitative study used in-depth interviewing and open-ended questions with a semistructured format. All interviews were audiotaped and transcribed. Twenty-one interviews were conducted with 16 participants. The researcher analyzed the data through the lens of symbolic interactionism.

Results:
The study identified various passage points as nurses progressed in establishing their professional identity in the first 3 years after graduation. These points required adaptation to stress to accomplish successful negotiation and included finding a niche, orientation, the conflict of caring, taking the licensure examination, becoming a charge nurse, and moving on. A sense of responsibility and the need for continual learning and perfection were inherent in all passage points.

Conclusion:
The significance of this study rests in situational influences on the construction of identity, the need for balance and support in the practice environment, passage points in the first 3 years of practice, and the organizational need to support nursing empowerment and voice.

J Contin Educ Nurs
2008;39(6):255–262.
Callus formation and bark moisture as potential physical defenses of northern red oak,Quercus rubra, against red oak borer,Enaphalodes rufulus(Coleoptera: Cerambycidae)
Authors: Fierke Melissa K. , Stephen Fred M. 
Published: March 2009

AbstractThe red oak borer,Enaphalodes rufulus(Haldeman), is a native wood-boring beetle implicated as a major contributor to recent high levels of oak mortality in northern Arkansas. Northern red oaks,Quercus rubraL. (Fagaceae), were grouped into three classes of red oak borer infestation history based on crown condition and basal red oak borer emergence holes: class I (low infestation), class II (moderate infestation), and class III (high infestation). In 2004 and 2005, trees from each class were mechanically wounded and callus formation was measured after one year. Class I trees exhibited significantly greater callus formation than class III trees in both years. Monthly measurements in spring and summer of 2006 indicated significant differences in callus formation among classes, with class I trees healing over significantly earlier. Moisture was measured in bark samples removed 1 week and 4 weeks after initiation of three treatments: control, mechanical wounding, and artificial insertion of larvae. Moisture levels did not vary among infestation classes or treatments. This research indicates that bark moisture is likely not a defense against red oak borer, but that callus overgrowth may be a defense early in the second year of the life cycle in healthy trees.
Attraction of male summerform pear psylla to volatiles from female pear psylla: effects of female age, mating status, and presence of host plant
Authors: Horton David R. , Guédot Christelle , Landolt Peter J. 
Published: March 2009

AbstractPear psylla, Cacopsylla pyricola (Förster) (Hemiptera: Psyllidae), is a pest of pears, Pyrus L. (Rosaceae), throughout North America and western Europe. Previous studies in our laboratory showed that males of the overwintering form (winter morphotype) were attracted to volatile chemicals from pear shoots infested with post-diapause females. The current study shows that males of the summer morphotype also are attracted to volatiles from female-infested host material. Older females (8–10 d old) were significantly more attractive to males than younger (2–5 d old) females. Both virgin and mated females attracted male psylla. Volatiles from female summerforms attracted males even in the absence of host-plant material, and both living and freshly killed females were attractive. Our results indicate that female C. pyricola emit a volatile sex attractant, and the results of the studies further define the life-history conditions in female pear psylla that lead to male attraction.
Recent Advances in the Synthesis of 2‐Imidazolines and Their Applications in Homogeneous Catalysis
Authors: Liu Han , Du Da‐Ming 
Published: March 2009

Abstractmagnified imageAs an important class of heterocyclic scaffolds, 2‐imidazolines have attracted the attention from the chemists interested in natural products, pharmaceutical chemistry, synthetic organic chemistry, coordination chemistry, and homogeneous catalysis. To fulfill the demand of structural diversity, many efficient methods towards 2‐imidazolines, as well as modifications of traditional methods, have been reported in the past two decades. 2‐Imidazolines have been developed as ligands in homogeneous catalysis, for the substitution on the nitrogen atom that provides an opportunity for fine‐tuning of the electronic effect. This review summarizes recent advances in the synthesis of 2‐imidazolines and their applications in homogeneous catalysis.
Dynamic operability analysis of nonlinear process networks based on dissipativity
Authors: Rojas Osvaldo J. , Setiawan Ridwan , Bao Jie , Lee Peter L. 
Published: March 2009

AbstractMost modern chemical plants are complex networks of multiple interconnected nonlinear process units, often with multiple recycle and by‐pass streams and energy integration. Interactions between process units often lead to plant‐wide operability problems (i.e., difficulties in process control). Plant‐wide operability analysis is often difficult due to the complexity and nonlinearity of the processes. This article provides a new framework of dynamic operability analysis for plant‐wide processes, based on the dissipativity of each process unit and the topology of the process network. Based on the concept of dissipative systems, this approach can deal with nonlinear processes directly. Developed from a network perspective, the proposed framework is also inherently scalable and thus can be applied to large process networks. © 2009 American Institute of Chemical Engineers AIChE J, 2009
A chaos‐based iterated multistep predictor for blast furnace ironmaking process
Authors: Gao Chuanhou , Chen Jiming , Zeng Jiusun , Liu Xueyi , Sun Youxian 
Published: March 2009

AbstractThe prediction and control of the inner thermal state of a blast furnace, represented as silicon content in blast furnace hot metal, pose a great challenge because of complex chemical reactions and transfer phenomena taking place in blast furnace ironmaking process. In this article, a chaos‐based iterated multistep predictor is designed for predicting the silicon content in blast furnace hot metal collected from a pint‐sized blast furnace. The reasonable agreement between the predicted values and the observed values indicates that the established high dimensional chaotic predictor can predict the evolvement of silicon series well, which conversely render the strong indication of existing deterministic mechanism ruling the dynamics of complex blast furnace ironmaking process, i.e., a high‐dimensional chaotic system is suitable for representing the blast furnace system. The results may serve as guidelines for characterizing blast furnace ironmaking process, an extremely complex but fascinating field, with chaos in the future investigation. © 2009 American Institute of Chemical Engineers AIChE J, 2009
Preparation and characterization of aliphatic polyurethane and hydroxyapatite composite scaffold
Authors: Liu Haohuai , Zhang Li , Zuo Yi , Wang Li , Huang Di , Shen Juan , Shi Pujiang , Li Yubao 
Published: March 2009

AbstractNovel porous composite scaffolds for tissue engineering were prepared from aliphatic biodegradable polyurethane (PU) elastomer and hydroxyapatite (HA). It was found that the aliphatic PU was possible to load up to 50 wt % HA. The morphology and properties of the scaffolds were characterized by scanning electron microscope, X‐ray diffraction, infrared absorption spectra, mechanical testing, dynamic mechanical analysis, and in vitro degradation measurement. The results indicated that the HA/PU scaffolds had an interconnected porous structure with a pore size mainly ranging from 300 to 900 μm, and 50–200 μm micropores existed on the pores' walls. The average pore size of macropores and micropores are 510 and 100 μm, respectively. The compressive strength of the composite scaffolds showed higher enhancement with increasing HA content. In addition, the polymer matrix was completely composed of aliphatic component and exhibited progressive mass loss in vitro degradation, and the degradation rate depended on the HA content in PU matrix. The porous HA/PU composite may have a good prospect to be used as scaffold for tissue engineering. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Preparation and characterization of scratch and mar resistant waterborne epoxy/silica nanocomposite clearcoat
Authors: Chen Songwei , You Bo , Zhou Shuxue , Wu Limin 
Published: March 2009

AbstractColloidal nano‐silica particles were used to improve the scratch and mar resistance of waterborne epoxy coatings by directly blending. To enhance the compatibility of nano‐silica particles within polymer matrix, nano‐silica particles were first modified with 3‐glycidoxypropyl‐trimethoxysilane (GPTMS) and characterized by Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). The modified nano‐silica particles were found to have a better dispersion and compatibility in the polymer matrix than the unmodified nano‐silica particles. Macro‐scratch and nano‐scratch testers were employed to characterize the scratch and mar resistances of the nanosilica‐reinforced epoxy coatings. Relative to unmodified nano‐silica, GPTMS‐modified nano‐silica particles can improve the scratch and mar resistance more significantly and reduce the transparency and gloss of waterborne epoxy coatings less seriously. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Distal biceps brachii tendon anatomy revisited from a surgical perspective
Authors: Fogg Quentin A. , Hess Benjamin R. , Rodgers K. Gary , Ashwood Neil 
Published: March 2009

AbstractThe distal biceps brachii tendon is commonly susceptible to traumatic injury. This study aimed to describe the morphology of the distal biceps brachii tendon in relation to the commonly used endobutton repair of tendon rupture. The results suggested that the distal tendon is a series of distinct bands of variable number. These bands are obscured surgically by the tendon sheath. Upon opening this sheath, blunt dissection of the tendon released fibrous connections between the tendon bands. Adjacent bands were variably connected via small oblique bands. The separations between bands were continuous onto the radius. They were therefore considered as separate force‐conducting units. This notion is of high relevance to endobutton repairs, as the sutures are typically only passed through the margins of the tendon. Where few connections exist between tendinous bands, this represents a potential weakness, as central bands are therefore free to be pulled proximally. This is of primary concern in the early rehabilitative stages of postoperative care. It may be suggested that sutures that cross the width of the tendon will eliminate the give of central bands, improving postoperative results, reducing revision numbers, and potentially reducing rehabilitation time. Clin. Anat. 22:346–351, 2009. © 2009 Wiley‐Liss, Inc.
Application of seeded batch crystallization methods for reduction of the scaling tendency of seawater – A study of growth kinetics of calcium carbonate in seawater
Authors: Omar W. , Chen J. , Ulrich J. 
Published: March 2009

AbstractThe objective of this study is to evaluate the applicability of a seeded batch crystallization method as a pre‐treatment stage to the reduction of the the scaling potential of seawater. The crystallization process of calcium carbonate in supersaturated seawater is studied experimentally in a seeded batch crystallizer. Results show that the initial pH value of seawater must be adjusted to be in the range of 8‐9. Calcite seeds will not have the potential to start the growth process in seawater at he the normal pH (7.36) compared to the above mentioned range. The growth kinetic parameters are determined from the measured desupersaturation curves. It is found that the growth process of calcite is controlled by surface integration step. The growth rate of calcite increases with increasing temperature and seeding ratio (up to 1 g/L), while it decreases with increasing the salinity of seawater. Crystals of calcite morphology are found to be growing faster than seeds of aragonite morphology. Stirrer speed has no distinct effect on the growth rate of calcite in seawater. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Crystal structure characterization of the quaternary compounds CuFeAlSe3 and CuFeGaSe3
Authors: Delgado G. E. , Mora A. J. , Contreras J. E. , Grima‐Gallardo P. , Durán S. , Muñoz M. , Quintero M. 
Published: March 2009

AbstractThe crystal structure of the chalcogenide compounds CuFeAlSe3 and CuFeGaSe3, belonging to the system I‐II‐III‐III3, were characterized using X‐ray powder diffraction data. Both compounds crystallize in the tetragonal space group P42c (N° 112), Z = 1, with unit cell parameters a = 5.609(1) Å, c = 10.963(2) Å for CuFeAlSe3 and a = 5.6165(3) Å, c = 11.075(1) Å for CuFeGaSe3. These compounds are isostructural with CuFeInSe3, and have a normal adamantane structure. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A demand side approach for congestion management in competitive environment
Authors: Shayesteh E. , Moghaddam M. P. , Yousefi A. , Haghifam M.‐R. , Sheik‐El‐Eslami M. K. 
Published: March 2009

AbstractThis paper proposes an approach for transmission congestion management (CM) in a deregulated power system. Transmission congestion mitigates network efficiency and results in increasing electricity price. Congestion can be effectively eliminated through several methods either by building a new transmission line or by increasing the capacity of the original line between congested zones. This paper evaluates the using of Demand Response (DR) programs in order to managing the congestion. For this purpose, a coordination process between GENCOs and the Independent System Operator (ISO) is considered. In the proposed approach, the coordination is modeled as a two‐stage process. At first, GENCOs apply price‐based unit commitment and submit their bids to the ISO for maximizing their profits. Then, the ISO clears the market using Day‐Ahead Demand Response Program (DADRP). Now, if any transmission violation exists, the ISO will run re‐dispatching of GENCO bids using Emergency Demand Response Program (EDRP) for minimizing the CM cost as well as omitting line flow violations. Numerical studies based on IEEE 57‐bus system are performed for the evaluation of the method. Copyright © 2009 John Wiley & Sons, Ltd.
Effects of mechanical stimuli on the synthesis of superficial zone protein in chondrocytes
Authors: Kamiya T. , Tanimoto K. , Tanne Y. , Lin Y. Y. , Kunimatsu R. , Yoshioka M. , Tanaka N. , Tanaka E. , Tanne K. 
Published: March 2009

AbstractSuperficial zone protein (SZP) has been demonstrated to contribute to the boundary lubrication in synovial joints. This study was designed to clarify the modulation of SZP expression by mechanical stress in articular chondrocytes. Cyclic tensile strains of 7 and 21% cell elongation were applied to cultured chondrocytes obtained from porcine mandibular condylar cartilage. The mRNA levels of SZP, IL‐1β, and TGF‐β1 were examined by a quantitative real‐time PCR analysis. Protein level of SZP was examined by Western blotting. The SZP mRNA level was significantly upregulated after 12, 24, and 48 h by 7% elongation. Although SZP mRNA level was upregulated by 21% elongation after 12 h, it decreased to a lower level than the control after 48 h. The TGF‐β1 mRNA level exhibited an almost similar change to SZP. The IL‐1β mRNA level was not changed markedly by 7% elongation. However, the IL‐1β mRNA level was significantly increased by a 12‐h application of 21% elongation. Western blot analysis revealed that the SZP expression was increased by 7% elongation, but decreased remarkably by 21% elongation. It is suggested from these findings that the SZP expression level in the chondrocytes is enhanced by optimal mechanical stimuli, but inhibited by excessive loading partly affected by TGF‐β1 and IL‐1β, leading to the deterioration of joint lubrication. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
Can low frequency electromagnetic field help cartilage tissue engineering?
Authors: Chang Chih‐Hung , Loo Siow‐Tung , Liu Hsuan‐Liang , Fang Hsu‐Wei , Lin Hsin‐Yi 
Published: March 2009

AbstractTo understand whether a low‐frequency pulsed electromagnetic field (EMF) could help cartilage tissue repair in the scope of tissue engineering, we tested how EMF affected collagen gel properties and the behaviors of chondrocyte cells embedded in collagen constructs. Collagen gel and primary chondrocytes embedded in collagen were exposed to EMF for 24 h. Gel and cells that were not exposed to EMF served as controls. Collagen gel exposed to EMF was more hydrophobic and less susceptible to enzymatic degradation (both p < 0.05) than control. Three weeks after EMF exposure, chondrocytes showed higher proliferation and lower glycosaminoglycan (GAG) production (both p < 0.05) than control. By the end of the third week, aggrecan, type I, II, and X collagen mRNA expressions in the EMF group were 1.8 times higher (p < 0.05), except for type II collagen) than control. The increase in gene expression did not show up in aggrecan histological staining and type II and type X collagen immunohistochemical staining. Cells from both groups kept a normal polygonal shape through out the test period. Our results suggested that one‐time EMF exposure could promote collagen‐embedded chondrocytes proliferation and their gene expressions. It also promoted short‐term (week 1) GAG production and lacuna formation. No apparent GAG and type II collagen production was seen in histological staining three weeks after the EMF exposure. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010