bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated Knowledge Graph Construction with Large Language Models
Authors: Kau Amanda 
Published: March 2024

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Harvesting the Power and Knowledge of Large Language Models
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Author
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Amanda Kau
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(ORCID:
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0009–0004–4949–9284
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Introduction Knowledge Graphs are networks that represent data in a graphical format. The beauty of Knowledge Graphs lies in their representation of concepts, events and entities as nodes, and the relationships between them as edges.
TATARİSTAN’DA AHMED YESEVÎ'NİN HAYATI VE ESERLERİ ÜZERİNE YAPILAN ÇALIŞMALARIN TARİHSEL İNCELEMESİ
Authors: Mingazova Liailia , Gelişli Yücel 
Published: March 2024

Hazret Sultan Şeyhülislam Hoca Ahmed Yesevi olarak da bilinen Ahmed Yesevi, İslam dünyasının önemli bir âlimi ve Türk tasavvufunun öncülerinden biridir. Kendisi 12. yüzyılda yaşamış bir şair ve tasavvufi ve İslami ilimler uzmanıydı. Yesevi, Türk halklarının İslami aydınlanmasına önemli katkılarda bulunmuştur(Özköse, 2016: 11).
Farklı ülkelerden çok sayıda akademisyen onun hayatı ve yaratıcı çalışmaları üzerine çeşitli çalışmalar yapmıştır. Bilimsel çalışmalar arasında Sufizm ve Sufi felsefesi konusu önemli bir yere sahiptir.
Bu makale, Sufi şair Ahmed Yesevi'nin hayatı ve faaliyetlerinin hem yerel hem de uluslararası Türkoloji çalışmalarında incelenmesini ele almaktadır. Tataristan'daki yayınların analizi, Ahmed Yesevi'nin eserlerinin Tatar teolojik düşüncesi ve Tatar edebiyat araştırmaları bağlamında incelenmesi bağımsız olarak ele alınmaktadır. Makale, Ahmed Yesevi'nin Tatarların manevi dünyasındaki rolü ve konumunun öneminin altını çizmektedir.
Yazar, Tatar akademisyenlerin konuyla ilgili araştırmalarını inceledikten sonra, çalışmaların genel nitelikte olduğunu tespit etmiştir. Mirasın analizi, Sovyet yönetimi yıllarında oluşan metodolojik klişelerin ve ideolojik önyargıların etkisi altında gerçekleştirilmiştir. Sonuç olarak, bu konuyla ilgili gelecekteki araştırma beklentileri ana hatlarıyla belirtilmiştir.
Makale, kültürün ve toplumsal düşüncenin evrimini incelerken tarihselcilik ilkesine ve sistem yaklaşımına öncelik veren somut-tarihsel bilişsel yönteme dayanmaktadır.
TDAH en entornos escolares, experiencia y autoconfianza de los maestros de educación general básica para la enseñanza efectiva.
Authors: Samaniego Luna Natasha Ivanova , Chamba Carchi Md. Yosselyn Nathaly 
Published: March 2024

Esta investigación definió como objetivo establecer la relación entre la experiencia de los maestros de niños con TDAH en los entornos escolares, y los niveles de autoconfianza para la enseñanza efectiva. Se aplicó a 342 maestros de educación general básica de la ciudad de Loja, una encuesta relacionada con aspectos sociodemográficos: edad, sexo, tipo de institución donde labora, trayectoria docente, año de educación básica en el que se desempeña, antigüedad, formación sobre TDAH, experiencia en el trabajo con niños que tienen esta patología, y, autoconfianza para lograr en ellos los aprendizajes requeridos .Se encontró un 81% (n=276) de mujeres en la muestra; el 68, 1% (n=233) de los maestros se ubicaron en edades de 40 a 64 años; el 84,5% (n=289) laboraba en instituciones públicas; 34,5% (n=118), tuvieron más de veinte años de experiencia docente; el 50,6% (n=173) accedieron a algún tipo de formación en TDAH. Menos de la mitad de los docentes contaron con experiencia educando a niños con TDAH y reconocieron autoconfianza para la enseñanza en estos casos.
Effects of Transition Curves and Superelevation on the Critical States of Truck Rollovers on Sharp Curves
Authors: Chen Junxian , Wang Yonggang 
Published: March 2024

Sharp curves are vulnerable sections for rollover accidents. This study was conducted to investigate the effects of transition curve and superelevation on the critical speed and critical braking distance of truck rollovers. Using different transition types (spiral, Bloss and Grabowski curve) and different superelevation values (6%, 120 m transition length and 8%, 160 m) as variables, experiments of constant speed driving and hard braking were simulated and conducted by Trucksim. Conclusions regarding the influence of these road design factors on the stability of vehicles were then proposed. Grabowski curve allowed for the maximum critical rollover speed. The difference in critical rollover speed between different transition types was only determined by the length of the transition section. Simply extending the length of the transition section increased the critical rollover speed of spiral curve, at the same time decreasing the critical speed of Bloss and Grabowski curve. Hard braking experiments showed completely different characteristics. As the initial speed increased, only spiral curve became safer. Increasing superelevation made the braking behaviour of the vehicle more dangerous and fraught with uncertainties due to different target speed, starting curvature and changing superelevation. Based on these findings, a number of useful recommendations for drivers and road designers were put forward.
Genome-wide identification, subcellular localization, and expression analysis of the phosphatidyl ethanolamine-binding protein family reveals the candidates involved in flowering and yield regulation of Tartary buckwheat (Fagopyrum tataricum)
Authors: Nie Mengping , Li Li , He Cailin , Lu Jing , Guo Huihui , Li Xiao’an , Jiang Mi , Zhan Ruiling , Sun Wenjun , Yin Junjie , Wu Qi 
Published: March 2024

Background
PEBP (phosphatidyl ethanolamine-binding protein) is widely found in eukaryotes including plants, animals and microorganisms. In plants, the PEBP family plays vital roles in regulating flowering time and morphogenesis and is highly associated to agronomic traits and yields of crops, which has been identified and characterized in many plant species but not well studied in Tartary buckwheat (Fagopyrum tataricum Gaertn.), an important coarse food grain with medicinal value.

Methods
Genome-wide analysis of FtPEBP gene family members in Tartary buckwheat was performed using bioinformatic tools. Subcellular localization analysis was performed by confocal microscopy. The expression levels of these genes in leaf and inflorescence samples were analyzed using qRT-PCR.

Results
Fourteen Fagopyrum tataricum PEBP (FtPEBP) genes were identified and divided into three sub-clades according to their phylogenetic relationships. Subcellular localization analysis of the FtPEBP proteins in tobacco leaves indicated that FT- and TFL-GFP fusion proteins were localized in both the nucleus and cytoplasm. Gene structure analysis showed that most FtPEBP genes contain four exons and three introns. FtPEBP genes are unevenly distributed in Tartary buckwheat chromosomes. Three tandem repeats were found among FtFT5/FtFT6, FtMFT1/FtMFT2 and FtTFL4/FtTFL5. Five orthologous gene pairs were detected between F. tataricum and F. esculentum. Seven light-responsive, nine hormone-related and four stress-responsive elements were detected in FtPEBPs promoters. We used real-time PCR to investigate the expression levels of FtPEBPs among two flowering-type cultivars at floral transition time. We found FtFT1/FtFT3 were highly expressed in leaf and young inflorescence of early-flowering type, whereas they were expressed at very low levels in late-flowering type cultivars. Thus, we deduced that FtFT1/FtFT3 may be positive regulators for flowering and yield of Tartary buckwheat. These results lay an important foundation for further studies on the functions of FtPEBP genes which may be utilized for yield improvement.
Comparison of the Outcome of Surgery and Radiotherapy in the Treatment of Early Carcinoma of the Larynx
Authors: Saha Bashudeb Kumar , Islam Md. Ashraful , Rumi Shaikh Nurul Fattah 
Published: March 2024

Background: The most prevalent disease to afflict the head and neck region is laryngeal cancer. The early stage of this disease, T1T2N0M0, has a higher chance of recovery than the other phases. Radiation therapy and surgery are its therapeutic techniques.
Objective: To Compare the outcome of surgery and radiotherapy in the treatment of early carcinoma of the larynx
Methods: This cross-sectional study was carried out at tertiary hospital Dhaka from January 2022 to January 2023. Where A total of 200 Patients of carcinoma of the larynx are evaluated properly by detailed history taking, clinical examination and relevant investigation. During the study two groups of patients were dealt separately; Group-1: Surgery using LASER, n=100 and Group-2: radiotherapy, n=200. All the patients were followed up after 2 weeks, 1 month and then three monthly for one year.
Results: During the study, supraglottis carcinoma was found in 65% of radiotherapy group and 70% in surgery group, glottic carcinoma was 35% & 30%, respectively in radiotherapy and surgery group. No case found with subglottic carcinoma. Where in surgery group 7% patients had haematoma, 5% patients had seroma & pharyngeal stenosis. In radiotherapy group 2.5% Severe radiation necrosis of skin & 3% had Respiratory distress following radiotherapy. . In the radiotherapy group, 25% cases were scored as normal and 45% as good. For the surgery group, 40% patients had good voice and speech, 35%r had moderate voice and speech, and 5% had poor voice and speech. This difference was statistically significant (p=.001). 14% of the irradiation group had a primary site recurrence compared with 20% in the surgery group at 12th months. There was a significant difference in the pattern of recurrence in the neck between the two treatment groups. Only 5% of those who were treated with irradiation had a recurrence in the neck. 14% of patients in the surgery group had a recurrence in the neck; this difference was statistically significant.
Conclusions: When treating early laryngeal cancer, radiation therapy and surgery are equally successful. However, patients who had radiation therapy had much improved speech and voice quality compared to those who received surgery.
Prevalence and Outcome of Paediatric Domestic Accidents in a Tertiary Health Facility in Rivers State, Nigeria
Authors: Okari T.G  , Wonodi W.  
Published: March 2024

Background: Unintentional injuries occurring in or within the vicinity of the home resulting in temporary or permanent health impairment are largely preventable. However, they are contributors to childhood morbidity and could lead to mortality in severe cases.
Objectives: This study was undertaken to determine the prevalence, pattern and outcome of domestic injuries among children admitted into the Children’s Emergency Room (CHER) in Rivers State University Teaching Hospital (RSUTH).
Methods: This was a 5-year retrospective study of 179 children with domestic injuries admitted into the children’s emergency unit from January 2017 to December 2021. Data on socio-demographic characteristics, cause, type and outcome of domestic injuries were collected from their medical records and analyzed with SPSS version 23.
Results: A total of 3987 children aged < 18 years were admitted into CHER. Out of these, 179 (4.48%) children had injuries from domestic accidents. Majority of them 89 (46.9%) were under-fives and males 108 (60.3%). Three commonest causes of home accidents were falls 52 (29.1%), burns 44 (24.6%) and mechanical trauma 32 (17.8%). Common domestic injuries observed in the study were burns (24.6%), head injuries (20.7%), ingestion of poisonous substances (13.4%) and lacerations (11.7%). Burns injuries were significantly more prevalent among females and poisoning among males. Incidents of poisoning was significantly more prevalent among under-fives (21.4%) and animal bites (13.7%) among older children, (p value < 0.05). The mean duration of admission in the emergency room was 1.27 ± 1.90 days. Three children (1.7%) died in the emergency room and all mortalities occurred within 48 hours of admission.
Conclusion: Although the prevalence of domestic injuries among children in this study was low, parents, caregivers and the government can institute measures to further curb its incidence.
A Sustainable Approach to Combat Micronutrient Deficiencies and Ensure Global Food Security through Biofortification
Authors: Rai Dipti , Chaudhary Charul , Khatak Aneeta , Banyal Sonika 
Published: March 2024

Micronutrient deficiencies, particularly in essential vitamins and minerals, pose a significant public health challenge, affecting over two billion people worldwide. These deficiencies contribute to various health issues, impaired cognitive development, and reduced productivity, ultimately hindering social and economic progress. Biofortification, a process of enhancing the nutritional content of staple crops through conventional breeding or genetic engineering, has emerged as a promising and sustainable approach to combat micronutrient deficiencies and ensure global food security. This review explores the potential of Biofortification as a cost-effective and sustainable solution to address hidden hunger and improve the nutritional status of vulnerable populations. Biofortification offers several advantages over traditional interventions, such as supplementation and food fortification. By targeting staple crops consumed by the majority of the population, Biofortification ensures a wide reach and sustained nutrient intake without requiring significant changes in dietary habits. Moreover, biofortified crops can be grown locally, reducing the reliance on external interventions and empowering farmers to improve their nutritional status and livelihoods. Numerous studies have demonstrated the efficacy of bio fortified crops in increasing micronutrient intake and improving health outcomes. For instance, iron-biofortified pearl millet has been shown to increase iron absorption and reduce anemia prevalence in children, while zinc-biofortified wheat has improved zinc status and reduced stunting. Additionally, vitamin A-biofortified sweet potato and cassava have significantly increased vitamin A intake and reduced vitamin A deficiency in various populations.
Despite the promising results, the success of Biofortification relies on several factors, including the development of nutrient-dense varieties, consumer acceptance, and effective dissemination strategies. Collaboration among researchers, policymakers, and stakeholders is essential to scale up Biofortification efforts and ensure their long-term sustainability. By prioritizing Biofortification as a key strategy in combating micronutrient deficiencies, we can work towards a more nourished and food-secure world.
Molecular simulation of separation of CO2 from flue gases in CU‐BTC metal‐organic framework
Authors: Yang Qingyuan , Xue Chunyu , Zhong Chongli , Chen Jian‐Feng 
Published: September 2007

AbstractIn this work, a computational study was performed on the adsorption separation of CO2 from flue gases (mixtures of CO2/N2/O2) in Cu‐BTC metal‐organic framework (MOF) to investigate the applicability of MOFs to this important industrial system. The computational results showed that Cu‐BTC is a promising material for separation of CO2 from flue gases, and the macroscopic separation behaviors of the MOF were elucidated at a molecular level to give insight into the underlying mechanisms. The present work not only provided useful information for understanding the separation characteristics of MOFs, but also showed their potential applications in chemical industry. © 2007 American Institute of Chemical Engineers AIChE J, 2007
Occipital atretic cephalocele, striking facial anomalies, and large feet in three siblings of a consanguineous union
Authors: Zechi‐Ceide Roseli Maria , Guion‐Almeida Maria Leine , Zanchetta Sthella , Richieri‐Costa Antonio 
Published: September 2007

AbstractHere, we report a newly recognized syndrome in three siblings with occipital atretic cephalocele, striking facial anomalies, and large feet. Specific findings include occipital atretic cephalocele, hypoplastic cerebellar vermis, Dandy–Walker variant, mental deficiency, prominent forehead, midface deficiency, broad nose and nasal root, grooved nasal tip, abnormal nares, narrow malformed ears, severe oligodontia, and large wide feet with a gap between the hallux and the second toe. The phenotype is variable in the three patients. The finding of three affected siblings of a consanguineous couple strongly suggests autosomal recessive inheritance. © 2007 Wiley‐Liss, Inc.
A newly recognized syndrome of Marfanoid habitus; long face; hypotelorism; long, thin nose; long, thin hands and feet; and a specific pattern of language and learning disabilities
Authors: Giacheti Célia M. , Zanchetta Sthella , Maranhe Elizandra , Cassab Tatiana V. , Abramides Dagma V. , Souza Deise H. , De‐Vitto Luciana P.M. , Richieri‐Costa Antonio 
Published: September 2007

AbstractHere, we report on a newly recognized syndrome in a Brazilian family with three affected women, who had a Marfanoid habitus; long face; hypotelorism; long, thin nose; long, thin hands and feet; and language and learning disabilities. The disorder is compatible with autosomal dominant inheritance. © 2007 Wiley‐Liss, Inc.
Effect of silane KH‐550 to polypropylene/brucite composite
Authors: Ma Zhiling , Wang Jinghui , Zhang Xiaoyu 
Published: September 2007

AbstractThe effect of the KH‐550 type silane coupling agent on the properties of polypropylene (PP)/brucite (BC) composite was studied. X‐ray diffraction, scanning electron microscope, and polarization optical microscope indicated that morphology structure of PP changed with the addition of KH‐550, which activated the heterogeneous nucleation centers on BC surface, which made the distribution of the spherulite diameter become narrow and uniform, and improved the dispersibility of BC in the matrix. Therefore, KH‐550 enhanced the interfacial adhesion of matrix‐filler and improved the compatibility of the PP/BC composite, when KH‐550's content was 2.9% the tensile strength and impact strength increased approximately by 90% and by 30%, respectively than PP/BC. Flow tests and IR proved that some reactions took place between BC and KH‐550. All the investigations showed KH‐550 was a proper coupling agent in the PP/BC composite. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
T cell epitopes of the La/SSB autoantigen in humanized transgenic mice expressing the hLa class II haplotype DRB1*0301/DQB1*0201
Authors: Dudek Nadine L. , Maier Shannon , Chen Zhen‐Jun , Mudd Philip A. , Mannering Stuart I. , Jackson David C. , Zeng Weiguang , Keech Catherine L. , Hamlin Kassie , Pan Zi‐Jian , Davis‐Schwarz Karen , Workman‐Azbill Jennifer , Bachmann Michael , McCluskey James , Farris A. Darise 
Published: September 2007

AbstractObjectiveT cells are implicated in the production of anti‐La/SSB and anti‐Ro/SSA autoantibodies commonly associated with the DR3/DQ2 haplotype in systemic lupus erythematosus and Sjögren's syndrome. This study was undertaken to investigate the DR3/DQ2‐restricted T cell response to wild‐type human La (hLa) and a truncated form of mutant La.MethodsHumanized transgenic mice expressing HLA–DRB1*0301/DQB1*0201 (DR3/DQ2) were immunized with recombinant antigen and examined for development of autoantibodies and T cell proliferation against overlapping peptides spanning the La autoantigen. HLA restriction and peptide binding of identified T cell epitopes to DR3 or DQ2 were determined using blocking monoclonal antibodies and a direct binding assay.ResultsDR3/DQ2‐transgenic mice generated an unusually rapid class‐switched humoral response to hLa with characteristic spreading to Ro 52 and Ro 60 proteins following hLa protein immunization. Seven T cell determinants in hLa were restricted to the HLA–DR3/DQ2 haplotype. Six epitopes tested were restricted to HLA–DR and bound DR3 with semiconserved DR3 binding motifs. No DQ restriction of these epitopes was demonstrable despite efficient DQ binding activity in some cases. No neo–T cell epitopes were identified in mutant La; however, T cells primed with mutant La exhibited a striking increase in proliferation to the epitope hLa151–168 compared with T cells primed with hLa.ConclusionMultiple DR3‐restricted epitopes of hLa have been identified. These findings suggest that truncation of La produced by somatic mutation or possibly granzyme B–mediated cleavage alters the immunodominance hierarchy of T cell responsiveness to hLa and may be a factor in the initiation or maintenance of anti‐La autoimmunity.
Hypoxia‐inducible factor 2α is essential for hypoxic induction of the human articular chondrocyte phenotype
Authors: Lafont Jérôme E. , Talma Sonia , Murphy Christopher L. 
Published: September 2007

AbstractObjectiveTo uncover the mechanism by which hypoxia enhances cartilage matrix synthesis by human articular chondrocytes.MethodsThe hypoxic response was investigated by exposing normal (nonarthritic) human articular chondrocyte cultures to 20% oxygen and 1% oxygen. Induction of the differentiated phenotype was confirmed at the gene and protein levels. In its first reported application in human articular chondrocytes, the RNA interference method was used to directly investigate the role of specific transcription factors in this process. Small interfering RNA directed against hypoxia‐inducible factor 1α (HIF‐1α), HIF‐2α, and SOX9 were delivered by lipid‐based transfection of primary and passaged human articular chondrocytes. The effect of each knockdown on hypoxic induction of the chondrocyte phenotype was assessed.ResultsHypoxia enhanced matrix synthesis and SOX9 expression of human articular chondrocytes at both the gene and protein levels. Although HIF‐1α knockdown had no effect, depletion of HIF‐2α abolished this hypoxic induction. Thus, we provide the first evidence that HIF‐2α, but not HIF‐1α, is essential for hypoxic induction of the human articular chondrocyte phenotype. In addition, depletion of SOX9 prevented hypoxic induction of matrix genes, indicating that the latter are not direct HIF targets but are up‐regulated by hypoxia via SOX9.ConclusionBased on our data, we propose a novel mechanism whereby hypoxia promotes cartilage matrix synthesis specifically through HIF‐2α–mediated SOX9 induction of key cartilage genes. These findings have potential application for the development of cartilage repair therapies.
Neutrophil gelatinase–associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 9
Authors: Gupta Kalpana , Shukla Meenakshi , Cowland Jack B. , Malemud Charles J. , Haqqi Tariq M. 
Published: September 2007

AbstractObjectiveExpression of matrix metalloproteinase 9 (MMP‐9) is up‐regulated in osteoarthritis (OA) and usually presents as multiple bands when synovial fluid (SF) from OA patients is analyzed by zymography. Among these bands is an ∼125–130–kd band for high molecular weight (HMW) gelatinase, which has not been characterized. This study was undertaken to characterize the HMW MMP activity in OA SF.MethodsMMP activity in OA SF was determined by gelatin zymography. Recombinant MMPs were used to identify MMP activity on the zymogram. Western immunoblotting, immunoprecipitation, and immunodepletion analyses were performed using antibodies specific for human MMP‐9 and human neutrophil gelatinase–associated lipocalin (NGAL). Human cartilage matrix degradation was determined by dimethylmethylene blue assay.ResultsZymographic analysis showed that the HMW gelatinase in OA SF comigrated with a purified NGAL–MMP‐9 complex. Results of Western immunoblotting showed that the HMW gelatinase was also recognized by antibodies specific for human NGAL or human MMP‐9. These same antibodies also immunoprecipitated the HMW gelatinase activity from OA SF. The NGAL–MMP‐9 complex was reconstituted in vitro in gelatinase buffer. In the presence of NGAL, MMP‐9 activity was stabilized; in the absence of NGAL, rapid loss of MMP‐9 activity occurred. MMP‐9–mediated release of cartilage matrix proteoglycans was significantly higher in the presence of NGAL (P < 0.05).ConclusionOur findings demonstrate that the HMW gelatinase activity in OA SF represents a complex of NGAL and MMP‐9. The ability of NGAL to protect MMP‐9 activity is relevant to cartilage matrix degradation in OA and may represent an important mechanism by which NGAL may contribute to the loss of cartilage matrix proteins in OA.