bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Drives the Spread and Bias in the Surface Impact of Sudden Stratospheric Warmings in CMIP6 Models?
Authors: Dai Ying , Hitchcock Peter , Simpson Isla R. 
Published: April 2024

Abstract
This study evaluates the representation of the composite-mean surface response to sudden stratospheric warmings (SSWs) in 28 CMIP6 models. Most models can reproduce the magnitude of the SLP response over the Arctic, although the simulated Arctic SLP response varies from model to model. Regarding the structure of the SLP response, most models exhibit a basin-symmetric negative Northern Annular Mode (NAM)-like response with a cyclonic Pacific SLP response, whereas the reanalysis shows a highly basin-asymmetric negative NAO-like response without a robust Pacific center. We then explore the drivers of these model biases and spread by applying a multiple linear regression (MLR). The results show that the polar cap temperature anomalies at 100 hPa (ΔT100) modulate the magnitude of both the Arctic SLP response and the cyclonic Pacific SLP response. Apart from ΔT100, the intensity and latitudinal location of the climatological eddy-driven jet in the troposphere also affect the magnitude of the Arctic SLP response. The compensation of model biases in these two tropospheric metrics and the good model representation of ΔT100 explain the good agreement between the ensemble mean and the reanalysis on the magnitude of the Arctic SLP response, as indicated by the fact that the ensemble mean lies well within the reanalysis uncertainty range and that the reanalysis mean sits well within the model distribution. The Niño-3.4 SST anomalies and North Pacific SST dipole anomalies together with ΔT100 modulate the cyclonic Pacific SLP response. In this case, biases in both oceanic drivers work in the same direction and lead to the cyclonic Pacific SLP response in models that are not present in the reanalysis.

Significance Statement
Sudden stratospheric warmings (SSWs) represent an important source of skill for forecasting winter weather on subseasonal-to-seasonal time scales. To what extent SSWs could be used to improve the prediction of surface weather depends on how well stratosphere–troposphere coupling associated with SSWs is represented in climate models. Therefore, we evaluate the representation of stratosphere–troposphere coupling associated with SSWs in 28 state-of-the-art climate models. The representation is found to diverge widely among climate models, and some are biased noticeably from the reanalysis. The models’ spread and bias are largely driven by five major factors and can be reduced substantially by making bias corrections to these factors.
Telephone advice lines for adults with advanced illness and their family carers: a qualitative analysis and novel practical framework
Authors: Pask Sophie , Omoruyi Allen , Mohamed Ahmed , Chambers Rachel L , McFarlane Phillippa G , Johansson Therese , Kumar Rashmi , Woodhead Andy , Okamoto Ikumi , Barclay Stephen , Higginson Irene J , Sleeman Katherine E , Murtagh Fliss EM 
Published: April 2024

Background: Telephone advice lines have been recommended internationally to support around-the-clock care for people living at home with advanced illness. While they undoubtedly support care, there is little evidence about what elements are needed for success. A national picture is needed to understand, improve and standardise service delivery/care. Aim: To explore telephone advice lines for people living at home with advanced illness across the four UK nations, and to construct a practical framework to improve services. Design: A cross-national evaluation of telephone advice lines using structured qualitative interviews. A patient and public involvement workshop was conducted to refine the framework. Setting/participants: Professionals with responsibilities for how palliative care services are delivered and/or funded at a local or regional level, were purposively sampled. Results: Seventy-one interviews were conducted, covering 60 geographical areas. Five themes were identified. Availability: Ten advice line models were described. Variation led to confusion about who to call and when. Accessibility, awareness and promotion: It was assumed that patients/carers know who to call out-of-hours, but often they did not. Practicalities: Call handlers skills/expertise varied, which influenced how calls were managed. Possible responses ranged from signposting to organising home visits. Integration/continuity of care: Integration between care providers was limited by electronic medical records access/information sharing. Service structure/commissioning: Sustained funding was often an issue for charitably funded organisations. Conclusions: Our novel evidence-based practical framework could be transformative for service design/delivery, as it presents key considerations relating to the various elements of advice lines that may impact on the patient/carer experience.
A Randomized Evaluation of MoodFX, a Patient-Centred e-Health Tool to Support Outcome Measurement for Depression: Une évaluation randomisée de MoodFX, un outil de santé en ligne centré sur le patient pour soutenir la mesure du résultat dans la dépression.
Authors: Li Victor W. , Sahota Jaspreet , Dev Deea K. , Gill Dib D. , Evans Vanessa C. , Axler Auby , Chakrabarty Trisha , Do André , Keramatian Kamyar , Nunez John-Jose , Tam Edwin M. , Yatham Lakshmi N. , Michalak Erin E. , Murphy Jill K. , Lam Raymond W. 
Published: April 2024

Background e-Health tools using validated questionnaires to assess outcomes may facilitate measurement-based care for psychiatric disorders. MoodFX was created as a free online symptom tracker to support patients for outcome measurement in their depression treatment. We conducted a pilot randomized evaluation to examine its usability, and clinical utility. Methods Patients presenting with a major depressive episode (within a major depressive or bipolar disorder) were randomly assigned to receive either MoodFX or a health information website as the intervention and control condition, respectively, with follow-up assessment surveys conducted online at baseline, 8 weeks and 6 months. The primary usability outcomes included the percentage of patients with self-reported use of MoodFX 3 or more times during follow up (indicating minimally adequate usage) and usability measures based on the System Usability Scale (SUS). Secondary clinical outcomes included the Quick Inventory of Depressive Symptomatology, Self-Rated (QIDS-SR) and Patient Health Questionnaire (PHQ-9). Results Forty-nine participants were randomized (24 to MoodFX and 25 to the control condition). Of the 23 participants randomized to MoodFX who completed the user survey, 18 (78%) used MoodFX 3 or more times over the 6 months of the study. The mean SUS score of 72.7 (65th–69th percentile) represents good usability. Compared to the control group, the MoodFX group had significantly better improvement on QIDS-SR and PHQ-9 scores, with large effect sizes and higher response rates at 6 months. There were no differences between conditions on other secondary outcomes such as functioning and quality of life. Conclusion MoodFX demonstrated good usability and was associated with reduction in depressive symptoms. This pilot study supports the use of digital tools in depression treatment.
Commentaire sur « Look up ! Cinq propositions de recherche pour repenser le marketing dans une société post-croissance » : le Marketing doit penser sa propre évolution à l’ère de l’Anthropocène
Authors: Dekhili Sihem , Merle Aurélie , Ochs Adeline 
Published: April 2024

Résumé Cet article fait suite à la proposition de Rémy et al. Il propose de réfléchir à l'évolution du marketing à l'ère de l'Anthropocène en trois temps. Dans un premier temps, il revient sur les constats macroéconomiques et clarifie certains postulats qui sont associés à tort à la vision du marketing durable attribuée à Dekhili et al. Dans un second temps, il développe le cadre de ce que devraient être les pratiques de marketing durable pour une organisation. Dans un dernier temps, il offre des pistes d’orientation pragmatiques pour des chercheurs en marketing souhaitant conduire des projets de recherche dans le contexte de l'Anthropocène.
Impact of Kangaroo Mother Care on Heart Rate Variability and Pain Score with Heel Lance Pain in Preterm Neonates: A Cross-over Randomized Controlled Trial
Authors: Jajoo Mamta , Mittal Medha , Saikia Diganta , Kumar Niraj 
Published: April 2024

Introduction: To evaluate the effect of kangaroo care on response to pain due to heel lance in preterm infants using premature infant pain profile (PIPP). Design: Randomized cross-over design. Methods: Stable preterm neonates ( n = 70) who had completed 28–36 weeks of gestational age received either kangaroo mother care or were kept under control (bassinet) conditions for 30 minutes prior to a heel lance. The neonates were observed, and responses were scored as per PIPP. They were then crossed over to the other condition and scored similarly. The PIPP scores in the two study arms were then compared using appropriate statistical tools. Results: A total of 342 neonates were admitted during the study period, of which 95 were assessed for eligibility, and finally, 70 were included and randomized to be in one of the two arms. The facial actions differed in the two groups; the brow bulge and eye squeeze scores were significantly better at each observation in the KMC group. The nasolabial furrow score was significantly better at 60 and 90 seconds. The baseline PIPP scores were similar. In the KMC group, the scores were significantly lower at 30, 60, and 90 seconds post–heel lance. Conclusions: Kangaroo mother care is an effective way of reducing the physiological and behavioral effects of pain in preterm neonates.
A Post-Hoc Analysis of Emotional Lability With Delayed-Release/Extended-Release Methylphenidate in Children Aged 6 to 12 Years of Age Participating in Two Phase 3 Clinical Trials
Authors: Arnold Valerie K. , López Frank A. , Childress Ann C. , Po Michelle D. , Uchida Cassandra L. , Cuthbertson Lewis , Sallee Floyd R. , Incledon Bev 
Published: April 2024

Objective: DR/ER-MPH (formerly HLD200) is an evening-dosed delayed-release and extended-release methylphenidate approved for the treatment of ADHD in patients ≥6 years. Post hoc analyses of two pivotal Phase 3 trials: HLD200-107 (NCT02493777) and HLD200-108 (NCT02520388) evaluated emotional lability (EL) with DR/ER-MPH treatment. Methods: Differences in Conners Global Index—Parent (CGI-P) EL subscale scores and age- and gender-adjusted T-scores over an open-label titration phase (HLD200-107) and between treatment and placebo groups at endpoint (HLD200-108) were evaluated. Results: In HLD200-107 ( N = 117) mean CGI-P EL subscale scores improved from 5.3 to 1.3 ( p < .0001) after 6 weeks; in HLD200-108 significant improvements were observed in the treatment group ( n = 81) versus placebo ( n = 80; 3.11 vs. 4.08; p = .0053). T-scores showed an improvement with DR/ER-MPH treatment in both trials. Few emotional adverse events (AEs) were reported. Conclusion: DR/ER-MPH treatment resulted in statistically significant improvements in EL to the level of non-ADHD peers as contextualized by T-scores.
Optical coherence tomography (OCT) and OCT-angiography in syndromic versus non-syndromic USH2A-associated retinopathy
Authors: Antropoli Alessio , Arrigo Alessandro , Caprara Carlo , Bianco Lorenzo , Mercuri Stefano , Berni Alessandro , Passerini Ilaria , Gambarotta Sofia , Sodi Andrea , Bandello Francesco , Murro Vittoria , Parodi Maurizio Battaglia 
Published: April 2024

Purpose To compare non-syndromic and syndromic forms of USH2A-related retinitis pigmentosa (RP) by means of structural optical coherence tomography (OCT) and OCT-angiography (OCTA). Methods Observational, cross-sectional, multicenter study. All patients underwent best corrected visual acuity (BCVA) measurement, OCT (Spectralis HRA + OCT, Heidelberg Engineering) and OCTA (OCT DRI Topcon Triton, Topcon Corporation). We compared subfoveal choroidal thickness (SCT), choroidal vascularity index (CVI), presence of cystroid macular edema (CME), macular vessel density (VD) at the superficial and deep capillary plexa, as well as VD of the radial peripapillary capillary (RPC) network, between syndromic and non-syndromic patients with USH2A-associated retinopathy. Results Thirty-four eyes from 18 patients (7 females) were included. Thirteen patients (72.2%) were affected by Usher syndrome type 2, whereas the remaining 5 subjects (27.8%) had non-syndromic retinitis pigmentosa (nsRP). Syndromic patients were younger than nsRP ( p = 0.01) and had a worse visual acuity than those with the exclusively retinal phenotype. Patients with Usher syndrome type 2 had a higher prevalence of CME and a thicker choroid compared to nsRP, although these results were not statistically significant ( p = 0.775 and p = 0.122, respectively). Similarly, none of the other quantitative OCT and OCTA parameters was statistically different between the two groups. Conclusions Despite their younger age, patients with Usher syndrome type 2 displayed similar choroidal and microvascular changes compared to those with nsRP.
Semi-adjustable posterior approach for congenital ptosis repair- outcomes of local and general anesthesia
Authors: Ben Ishai Meydan , Ben Artsi Elad , Shouchane-Blum Karny , Kramarz Dadon Judith , Avisar Inbal 
Published: April 2024

Background To report a single center experience with semi-adjustable posterior approach levator plication (‘levatorpexy’) in patients with congenital ptosis. Materials and methods A retrospective study. All cases who underwent posterior approach levatorpexy for congenital ptosis between the years 2016 to 2022 were included. The primary outcome measures were margin-to-reflex distance 1 (MRD1) before and after surgery, upper eyelid contour, symmetry of upper eyelid height, complications, and surgical success. Surgery was successful if all the following criteria were met: A postoperative MRD1 of ≥2 mm and ≤4.5 mm, a satisfactory eyelid contour in the operated eyelid, and an inter-eyelid MRD1 asymmetry of ≤1 mm. Postoperative modifications in semi-adjustable techniques were considered in all cases. Results Twenty-three eyelids of 21 patients were included, 11 were performed under general anesthesia, and 12 were performed under local anesthesia. The mean age of all patients was 24.1 years (8–47 years). The mean levator function was 11.2 (±2.11). Mean preoperative MRD1 was 1.05 mm and 1.41 for general and local anesthesia, respectively. Mean postoperative MRD1 was 3.33 mm and 3.37 mm for general and local anesthesia, respectively. Eighteen patients (85%) achieved the desired eyelid height and fulfilled our criteria for success. There were no complications reported in any of the groups. Conclusion Posterior approach levatorpexy is a safe and effective procedure for repairing congenital ptosis in patients with good levator function. This technique is suitable for young patients and those unable to undergo surgery under local anesthesia. This technique offers post-operative modification due to its semi-adjustable nature.
Effect of early cannulation with metal needles on arteriovenous fistula patency in patients undergoing hemodialysis
Authors: Jiang Zuanhong , Liu Manman , Zhou Lingling , Chen Weizhen , Lou Lili , Xu Liyun 
Published: April 2024

Background: Autogenous arteriovenous fistula (AVF) is the preferred vascular access mode. However, the earliest possible time for AVF puncture and whether premature puncture affects the AVF patency rate remain unclear. Methods: In this multicenter retrospective cohort study, adult uremic patients who underwent AVF surgery for the first time at Taizhou Hospital or Enze Hospital of Zhejiang Province between September 1, 2018 and August 31, 2021 were enrolled. All patients were followed up for 1 year after puncture, and the status of fistula establishment and puncture, subsequent patency, loss to follow-up, renal transplantation, conversion to peritoneal dialysis, abandonment of the fistula, and death, were recorded. Results: A total of 465 patients with AVFs were included in this study, including 59 (12.7%) patients with fistulas that were cannulated within 30 days. In the early puncture group, the levels of serum creatinine and urea nitrogen were higher, while the levels of hemoglobin and albumin were lower, suggesting that these patients needed urgent dialysis. Furthermore, the rate of non-cuffed catheter use was higher, while the rate of cuffed catheter use was lower, and femoral vein puncture was preferred over internal jugular vein puncture. The mean duration of catheter indwelling was shorter in the early puncture group (19 vs 70 days, p < 0.001). The estimated AVF primary and cumulative functional patency at 12 months was 81.1% versus 82.3% and 98.3% versus 98.7% in the early puncture and control groups, respectively. Kaplan–Meier analysis revealed no significant difference in AVF primary and cumulative functional patency between the two groups. Conclusions: In patients with an established fistula in urgent need of hemodialysis, to avoid new catheterization, a puncture can be performed within 30 days in those with well-developed blood vessels after adequate ultrasound and clinical evaluation without affecting the patency of the fistula.
COVID-19 mortality among immigrants by duration of residence in Sweden: a population-based cohort study
Authors: Juárez Sol P. , Debiasi Enrico , Wallace Matthew , Drefahl Sven , Mussino Eleonora , Cederström Agneta , Rostila Mikael , Aradhya Siddartha 
Published: April 2024

Background: Explanations for the disproportional COVID-19 burden among immigrants relative to host-country natives include differential exposure to the virus and susceptibility due to poor health conditions. Prior to the pandemic, immigrants displayed deteriorating health with duration of residence that may be associated with increased susceptibility over time. The aim of this study was to compare immigrant–native COVID-19 mortality by immigrants’ duration of residence to examine the role of differential susceptibility. Methods: A population-based cohort study was conducted with individuals between 18 and 100 years old registered in Sweden between 1 January 2015 and 15 June 2022. Cox regression models were run to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Inequalities in COVID-19 mortality between immigrants and the Swedish-born population in the working-age group were concentrated among those of non-Western origins and from Finland with more than 15 years in Sweden, while for those of retirement age, these groups showed higher COVID-19 mortality HRs regardless of duration of residence. Both age groups of immigrants from Africa and the Middle East showed consistently higher COVID-19 mortality HRs. For the working-age population: Africa: HR<15: 2.46, 95%CI: 1.78, 3.38; HR≥15: 1.49, 95%CI: 1.01, 2.19; and from the Middle East: HR<15: 1.20, 95%CI: 0.90, 1.60; HR≥15: 1.65, 95%CI: 1.32, 2.05. For the retirement-age population: Africa: HR<15: 3.94, 95%CI: 2.85, 5.44; HR≥15: 1.66, 95%CI: 1.32, 2.09; Middle East: HR<15: 3.27, 95%CI: 2.70, 3.97; HR≥15: 2.12, 95%CI: 1.91, 2.34. Conclusions: Differential exposure, as opposed to differential susceptibility, likely accounted for the higher COVID-19 mortality observed among those origins who were disproportionately affected by the pandemic in Sweden.
Reactive cutaneous capillary endothelial proliferation following camrelizumab monotherapy or combination therapy for multi-cancers: a large-scale pooled analysis of 10 studies in China
Authors: Qu Wenshu , Wang Feng , Qin Shukui , Sun Yuqi , Huang Chuanpei 
Published: April 2024

Background: Skin toxicities are the most common adverse events related to immunotherapy, such as reactive cutaneous capillary endothelial proliferation (RCCEP) following treatment with the anti-programmed cell death-1 antibody camrelizumab. Objective: This study aimed to comprehensively analyze the clinical features and prognostic value of RCCEP in patients with malignancies who received camrelizumab alone (Camre) or in combination with the angiogenesis-targeted agent apatinib (Camre-Apa) or chemotherapy (Camre-Chemo). Design: A large-scale pooled analysis. Methods: Individual patient-level data were derived from 10 clinical trials of camrelizumab monotherapy, camrelizumab plus apatinib, or camrelizumab plus chemotherapy ( n = 1305). Results: RCCEP occurred in 77.0% (516/670) of patients with Camre, 23.6% (70/296) with Camre-Apa, and 67.8% (230/339) with Camre-Chemo. Most RCCEP lesions were grade 1 or 2 in severity. The median time to onset was 0.8 months [interquartile range (IQR), 0.6–1.2] with Camre, 5.0 months (IQR, 2.7–8.0) with Camre-Apa, and 1.6 months (IQR, 1.0–4.2) with Camre-Chemo; and the median duration was 4.8 months (IQR, 2.6–8.8), 4.4 months (IQR, 1.7–8.9), and 7.2 months (IQR, 4.1–14.3), respectively. In all the three groups, patients with RCCEP showed significantly better clinical outcomes compared with those without [objective response rate: 23.8% versus 1.9% with Camre, 48.6% versus 21.2% with Camre-Apa, and 78.7% versus 54.1% with Camre-Chemo; median progression-free survival: 3.2 versus 1.7 months (hazard ratio (HR) = 0.36), 10.2 versus 4.5 months (HR = 0.39), and 12.7 versus 7.3 months (HR = 0.38); median overall survival: 13.3 versus 3.8 months (HR = 0.34), 29.2 versus 13.5 months (HR = 0.46), and not reached versus 12.8 months (HR = 0.19); all p < 0.0001]. Conclusion: Although RCCEP occurred frequently with camrelizumab, most lesions were mild and self-limiting. The occurrence of RCCEP was strongly associated with the antitumor activity and survival of camrelizumab, both as monotherapy and in combination therapy.
The impact of baseline dietary fatty acid intake on the association between lipoprotein(a) and mortality in two US cohorts
Authors: Patel Nimai , Chennareddy Chaitanya , Brandt Eric J 
Published: April 2024

Background Lipoprotein(a) (Lp(a)) is an established casual risk factor for atherosclerotic cardiovascular disease. It remains unknown whether dietary fat modifies the association of Lp(a) with cardiovascular death. Aim To understand if dietary fat modifies the association between Lp(a) and cardiovascular death. Methods We utilized the Atherosclerotic Risk in Communities (ARIC) study and National Health and Nutrition Examination Survey (NHANES) III cohorts and used multivariate cox proportional hazard modeling to test the association between Lp(a), dietary fats, and cardiovascular death. Results The sample ( n = 22,805) had average age 51.3 years and was mostly female (55.4%). Lp(a) ≥ 30 mg/dL was associated with CV death in both ARIC (1.36, p = 0.001) and NHANES (1.31, p = 0.03). In multivariate analysis, no categorical or individual fatty acids modified the association between Lp(a) and CV death. Conclusion There was no evidence that baseline dietary fat intake modified the association between Lp(a) and CV death.