bluuebunny/crossref_metadata_2025_split huggingface dataset:
The vascular footprint in cardiac homeostasis and hypertensive heart disease—A link between apelin receptor, vascular endothelial growth factor, and neuronal nitric oxide synthase
Authors: Iliev Alexandar , Gaydarski Lyubomir , Kotov Georgi , Landzhov Boycho , Kirkov Vidin , Stanchev Stancho 
Published: April 2024

AbstractRecent studies have suggested a connection between disturbances of the apelin system and various cardiac pathologies, including hypertension, heart failure, and atherosclerosis. Vascular endothelial growth factor is crucial for cardiac homeostasis as a critical molecule in cardiac angiogenesis. Neuronal nitric oxide synthase is an essential enzyme producing nitric oxide, a key regulator of vascular tone. The present study aims to shed light upon the complex interactions between these three vital signaling molecules and examine their changes with the progression of hypertensive heart disease. We used two groups of spontaneously hypertensive rats and age‐matched Wistar rats as controls. The expression of the apelin receptor, vascular endothelial growth factor, and neuronal nitric oxide synthase were assessed immunohistochemically. We used capillary density and cross‐sectional area of the cardiomyocytes as quantitative parameters of cardiac hypertrophy. Immunoreactivity of the molecules was more potent in both ventricles of spontaneously hypertensive rats compared with age‐matched controls. However, capillary density was lower in both ventricles of the two age groups of spontaneously hypertensive rats compared with controls, and the difference was statistically significant. In addition, the cross‐sectional area of the cardiomyocytes was higher in both ventricles of the two age groups of spontaneously hypertensive rats compared with controls, and the difference was statistically significant. Our study suggests a potential link between the apelin receptor, vascular endothelial growth factor, and neuronal nitric oxide synthase in cardiac homeostasis and the hypertensive myocardium. Nevertheless, further research is required to better comprehend these interactions and their potential therapeutic implications.
Assess the Effectiveness of Multichannel Analysis of Surface Waves Method in Mapping Ancient Structures in Ultrashallow Aquatic Environments: The Case of Agioi Theodoroi, Greece
Authors: Kritikakis George , Papadopoulos Nikos , Andronikidis Nikos , Simyrdanis Kleanthis , Theodoulou Theotokis 
Published: April 2024

ABSTRACTThe present geophysical research aims to evaluate the applicability of multichannel analysis of surface waves (MASW) on mapping ultrashallow underwater ancient masonry remnants. The work presents the analysis from a single seismic line using MASW and seismic refraction tomography (SRT) methods and its corresponding electrical resistivity tomography (ERT) section surveyed at the submerged prehistoric site of Agioi Theodoroi area located 10 km eastern of Heraklion, Crete, Greece. The 2D MASW velocity model exhibits significant correspondence with the resistivity structure extracted from the ERT data, showing lateral S‐wave velocity (Vs) variations at the positions where the high resistivity anomalies exist. The analysis of synthetic seismic data calculated from a respective model reproduced a comparable S‐wave velocity pseudo‐section with the real data. However, the investigated targets (submerged buried masonry) appear shallower and wider in MASW sections than in the real world and the corresponding synthetic models, due to insufficient vertical and horizontal resolution of this method. Surface waves travelling through the seafloor sediments (Scholte‐waves) demonstrate very low velocity values. This makes them suitable for the detection of shallow and relatively large (> 0.5 m) underwater manmade structures, providing the enhancement of MASW method resolution, by utilizing a high frequency (> 100 Hz) seismic source, recording short Scholte wavelengths (≤ 1 m) and using shorter (≤ 0.5 m) receiver spacing and array length. Consequently, the results of this work demonstrate the potential in employing conventional seismic techniques in the delineation of underwater antiquities and the revealing of the cultural dynamics in very shallow off‐shore archaeological sites.
Re‐imagining a decolonised, anti‐racist curriculum within initial teacher education in a Welsh university
Authors: Davis Susan , Watkins Sharne , Haughton Chantelle , Oliver Eve , Farag Josephine , Webber Paula , Goold Samuel 
Published: April 2024

AbstractChanges to the Welsh curriculum are becoming apparent. The Williams Report culminated in recommendations for schools and initial teacher education (ITE) on the inclusion and teaching of Black Asian and Minority Ethnic histories in Wales. The subsequent Welsh Government ITE action plan was designed to ensure the pro‐active recruitment of trainee teachers from Black and racially minoritised backgrounds in Wales. As a result of this legislation, a team of ITE lecturers in a school of education in a Welsh university formed a research triad and larger research collective, the idea being that we needed to decolonise our own pedagogy and curriculum delivery and re‐imagine ITE within an anti‐racist paradigm. It was key to reflect on our ITE provision, ensuring that our curriculum delivery reflected the ambition of the new Curriculum for Wales,* which encourages practitioners to think differently on what they teach, how they teach and what they want young people to learn. Using a patchwork methodology—which included ‘deep thinking and deep listening’—we examined our current ITE delivery and work that has been done thus far and looked at the gains and areas for development. It became clear that staff within our ‘ITE research collective’ were becoming more knowledgeable and confident in working within a racial dynamic, and consequently felt more able to impart knowledge when engaging with other ITE colleagues and students. This paper charts our ongoing journey and makes recommendations gained from our experiences.
Investigation of the mechanism of nephrotoxicity of nux‐vomica by PTGS2/CYP2C9‐mediated arachidonic acid pathway and Jian Pi Tong Luo compound's protective effect
Authors: Zhang Na , An Baisong , Zhao Liangyou , Zhao Dapeng , Lv Bochuan , Liu Shumin 
Published: April 2024

AbstractThe clinical effectiveness of nux‐vomica in treating rheumatism and arthralgia is noteworthy; however, its nephrotoxicity has sparked global concerns. Hence, there is value in conducting studies on detoxification methods based on traditional Chinese medicine compatibility theory. Blood biochemistry, enzyme‐linked immunosorbent assay, and pathological sections were used to evaluate both the nephrotoxicity of nux‐vomica and the efficacy of the Jian Pi Tong Luo (JPTL) compound in mitigating this toxicity. Kidney metabolomics, using ultra‐high‐performance liquid chromatography–quadrupole‐time‐of‐flight–MS (UPLC–Q‐TOF–MS), was applied to elucidate the alterations in small‐molecule metabolites in vivo. In addition, network pharmacology analysis was used to verify the mechanism and pathways underlying the nephrotoxicity associated with nux‐vomica. Finally, essential targets were validated through molecular docking and western blotting. The findings indicated significant nephrotoxicity associated with nux‐vomica, while the JPTL compound demonstrated the ability to alleviate this toxicity. The mechanism potentially involves nux‐vomica activating the “PTGS2/CYP2C9–phosphatidylcholine–arachidonic acid metabolic pathway.” This study establishes a scientific foundation for the clinical use of nux‐vomica and lays groundwork for further research and safety assessment of toxic Chinese herbal medicines.
Foreign ownership and product market competition's influence on firm performance: Mediating role of the corporate governance index
Authors: Tran Thu Thi , Ha Thach Xuan , Vo Nhan Kim 
Published: April 2024

AbstractThis study examines the influence of foreign ownership and product market competition on firm performance in Vietnam's listed companies through the mediating role of the corporate governance index. Moreover, the study explores the moderating role of business strategy in the relationships between foreign ownership, product market competition, and firm performance. We use maximum likelihood structural equation modeling in Stata 14 software to analyze the data collected from 180 Vietnamese listed companies from 2015 to 2019. The results indicate that foreign ownership and product market competition positively influence firm performance by mediating the corporate governance index. Business strategy negatively moderates the relationship between product market competition and firm performance. This study has implications for managers focusing on foreign ownership and product market competition to improve corporate governance systems, enhancing firm performance. Additionally, managers may build business strategies when product market competition increases to avoid negative effects on firm performance.
Digital data‐driven technologies and the environmental sustainability of micro, small, and medium enterprises: Does size matter?
Authors: Hernández Virginia , Revilla Antonio , Rodríguez Alicia 
Published: April 2024

AbstractDespite the increasing interest in understanding the relations between firms' digitalization and their environmental sustainability, they are still poorly understood as research on this hot topic is nascent and empirical evidence is sparse and fragmented. In this study, we delve into the relations between different digital data‐driven technologies (DTs) used for gathering and storing (smart devices and cloud computing), analyzing (Big Data and Artificial Intelligence), and sharing data (Blockchain) and environmental sustainability in micro, small, and medium enterprises (MSMEs). These firms, despite their relevance in the business landscape and their heterogeneity, are understudied in this area. Thus, we also examine the moderating role of firm size to understand the inherent diversity of MSMEs in the use of DTs and the development of the sustainability oriented practices. Empirical results from a large‐scale representative sample of European enterprises show that the adoption of DTs for data gathering and analysis is positively associated with sustainability‐oriented actions in MSMEs. The findings also reveal the positive moderating role of size: relations between data analysis and sharing technologies and sustainability are stronger for larger MSMEs, with the latter being significant only for medium‐sized enterprises.
Controlling Diastereoselectivity in Dearomatizing Diels‐Alder Reactions of Nitroarenes with 2‐Trimethylsilyloxycyclohexadiene
Authors: Powderly Marian , Roseau Mélanie , Frison Gilles , Hammami Rayhane , Chausset‐Boissarie Laetitia , Harrowven David , Legros Julien , Chataigner Isabelle 
Published: April 2024

AbstractDearomative Diels‐Alder cycloadditions between nitroarenes and 2‐trimethylsilyloxycyclohexadiene are carried out under high pressure at room temperature in the absence of any chemical promoter. Reactions are performed with different arenes, including the highly aromatic naphthalenes and quinolines. They lead to 3D‐scaffolds with exquisite exo‐diastereoselectivity. The exo approach is characterized by lower distortion of the substrates in a late TS and by more favorable orbital interactions presumably between the nitro group and the dienic part, explaining the stereoselectivity.
The Formation of Carbon Dots from D‐Glucose Studied by Infrared Spectroscopy
Authors: Fois Livia , Stagi Luigi , Carboni Davide , Alboushi Meera , Khaleel Abbas , Anedda Roberto , Innocenzi Plinio 
Published: April 2024

AbstractCarbon dots (C‐dots) obtained from D‐glucose have attracted great interest because of their properties and as a model for understanding the synthesis process and the origin of photoluminescence in carbon‐based nanostructures. Synthesising C‐dots under hydrothermal conditions has become one of the most common methods for their preparation. Understanding the details of this process is quite difficult. To tackle this challenge, we have adopted a multi‐technique approach in our present work. We have correlated different spectroscopic analyses, such as infrared, Raman, fluorescence, NMR, and UV‐Vis, to connect the emissions with specific chemical groups. In particular, in situ infrared analysis as a function of temperature has allowed following the formation of C=C, C=O, and COOH species and the rise of specific emissions. Only weak emissions due to n‐π* transitions are detected upon post‐synthesis thermal annealing.
Tuning the Emission Properties of 2,1,3‐Benzothiadiazoles via Regioselective Substitution
Authors: Posada Urrutia Mauricio , Dyrager Christine 
Published: April 2024

AbstractThe 2,1,3‐benzothiadiazole (BTD) unit is a prominent building block commonly used in various research areas such as optoelectronics and bioimaging. Despite its great versatility, the development of strategies to elaborate BTD has been largely neglected, including exploring its reactivity and understanding how regioselective functionalization can be used to tune the fluorescence emission. Previous focus has primarily been on C4‐ or C4,C7‐substitutions. Here, a series of unsymmetrical mono – and disubstituted BTDs was synthesized and characterized for their photophysical properties. The reaction scope includes all six possible substituent patterns on the BTD benzoid ring (C4‐, C5‐, C4,C5‐, C4,C6‐, C4,C7‐ and C5,C6‐substitution), which comprise arrangements that previously been synthetically challenging to access. By introducing a methoxy and/or a phenyl group we demonstrate that the emissive behavior of BTD derivatives strongly depends on the position of the substituent (s). We show that regioselective substitution on BTD can engender long‐lived fluorescence and circumvent strong fluorescence quenching in polar protic solvents, which is a limitation of many previously described BTD derivatives.
Regioselective Synthesis of Hamilton‐Receptor‐Fullerene Oligo‐Adducts for the Supramolecular Binding of Cyanuric Derivatives
Authors: Wachter Michael , Scholz Barbara , Schulze Erik J. , Hampel Frank , Pérez‐Ojeda M. Eugenia , Hirsch Andreas 
Published: April 2024

AbstractA new concept for the regioselective synthesis of Hamilton‐receptor and cyanurate‐functionalized oligo adducts of the fullerene C60 was developed. Based on an in‐situ deprotection and click‐post‐functionalization approach with novel azido precursors, the corresponding fullerene hexakis‐adducts with octahedral addition patterns and up to twelve Hamilton‐receptor/cyanurate moieties surrounding the fullerene sphere were synthesized. The versatility of this approach was further demonstrated by the synthesis of Hamilton‐receptor/cyanurate functionalized fullerene mono‐adducts, which are not accessible by direct cyclopropanation. Several fullerene target compounds were purified by simple washing procedures of the solid crude reaction mixture without the need for chromatography. The resulting fullerene mono‐ and hexakis‐adducts were fully characterized and their supramolecular properties were investigated by NMR‐spectroscopy and isothermal titration calorimetry (ITC).
Investigation of Isolated IrF5−, IrF6− Anions and M[IrF6] (M=Na, K, Rb, Cs) Ion Pairs by Matrix‐Isolation Spectroscopy and Relativistic Quantum‐Chemical Calculations
Authors: Lu Yan , Wodyński Artur , Reimann Marc , Medel Robert , Kaupp Martin , Riedel Sebastian 
Published: April 2024

AbstractThe molecular IrF5−, IrF6− anions and M[IrF6] (M=Na, K, Rb, Cs) ion pairs were prepared by co‐deposition of laser‐ablated alkali metal fluorides MF with IrF6 and isolated in solid neon or argon matrices under cryogenic conditions. The free anions were obtained as well by co‐deposition of IrF6 with laser‐ablated metals (Ir or Pt) as electron sources. The products were characterized in a combined analysis of matrix IR spectroscopy and electronic structure calculations using two‐component quasi‐relativistic DFT methods accounting for spin‐orbit coupling (SOC) effects as well as multi‐reference configuration‐interaction (MRCI) approaches with SOC. Inclusion of SOC is crucial in the prediction of spectra and properties of IrF6− and its alkali‐metal ion pairs. The observed IR bands and the computations show that the IrF6− anion adopts an Oh structure in a nondegenerate ground state stabilized by SOC effects, and not a distorted D4h structure in a triplet ground state as suggested by scalar‐relativistic calculations. The corresponding “closed‐shell” M[IrF6] ion pairs with C3v symmetry are stabilized by coordination of an alkali metal ion to three F atoms, and their structural change in the series from M=Na to Cs was proven spectroscopically. There is no evidence for the formation of IrF7, IrF7− or M[IrF7] (M=Na, K, Rb, Cs) ion pairs in our experiments.
Does Researcher Allegiance Bias Outcomes in Psychotherapy Research? A Quasi‐Experimental Secondary Analysis
Authors: Zimmerman Jacob A. , Marcus David K. 
Published: April 2024

ABSTRACTResearchers who conduct studies comparing the efficacy of two treatments often find that their preferred treatment outperforms the comparison treatment. This finding has been labelled the allegiance association. Although this association is robust, it is unclear whether it reflects an allegiance bias on the part of the researchers or whether it is noncausal, with researchers being allied to the more effective treatments. This study applied a quasi‐experimental method proposed by a previous study to 19 pairs of treatment comparison studies. Each member of a pair had used the same two psychotherapies to treat clients with the same disorder, but the researchers in each of the two studies had opposing allegiances. If the authors of one study in the pair concluded that their preferred treatment was superior and the authors of the other study concluded that their preferred treatment was superior or that the two treatments were equivalent, these patterns would suggest allegiance bias. In 10 of the 19 pairs, the patterns were consistent with the operation of an allegiance bias, indicating that although allegiance biases are not inevitable, they are ubiquitous. Practitioners and other psychotherapy research consumers should use caution when interpreting the findings from treatment comparison studies.
Heterointerface‐Rich Ni3N/WO3 Hierarchical Nanoarrays for Efficient Glycerol Oxidation‐Assisted Alkaline Hydrogen Evolution
Authors: Wang Hongjing , Zhan Wenjie , Jiang Shaojian , Deng Kai , Wang Ziqiang , Xu You , Yu Hongjie , Wang Liang 
Published: April 2024

AbstractGlycerol oxidation‐assisted water electrolysis has emerged as a cost‐effective way of co‐producing green hydrogen and HCOOH. Still, preparing highly selective and stable nickel‐based metal electrocatalysts remains a challenge. Herein, heterostructure Ni3N/WO3 nanosheet arrays of bifunctional catalysts with large specific surface areas loaded on nickel foam (denoted as Ni3N/WO3/NF) were synthesized. This catalyst was for glycerol oxidation reaction (GOR) and hydrogen evolution reaction (HER) with excellent catalytic performance, a voltage saving of 267 mV compared to oxygen evolution reaction (OER), and a HER overpotential of 104 mV at 100 mA cm−2. The cell voltage in the assembled GOR//HER hybrid electrolysis system reaches 100 mA cm−2 at 1.50 V, 296 mV lower than the potential required for overall water splitting. This work demonstrates that replacing GOR with OER using a cost‐effective and highly active Ni‐based bifunctional electrocatalyst can make hybrid water electrolysis an energy‐efficient, sustainable, and green strategy for hydrogen production.
Chitinase 3‐like 1 expression associated with lymphatic metastasis and prognosis in urothelial carcinoma of the bladder
Authors: Wang Bo , Chen Ke , Gao Mingchao , Sun Xi , He Wang , Chen Junyu , Yang Wenjuan , Yang Tenghao , Qin Haide , Ruan Honglian , Huang Hao , Lin Tianxin , Huang Jian 
Published: April 2024

AbstractObjectivesLymphatic metastasis, an early stage of the metastasis process, is associated with adverse clinical outcomes in urothelial carcinoma of the bladder (UCB). However, the role of inflammation in triggering lymphatic metastasis remains unclear.MethodsWe employed an RNA‐sequencing cohort (n = 50) from Sun Yat‐Sen Memorial Hospital (SYMH) to identify the most highly upregulated inflammatory gene associated with lymphatic metastasis. Using immunohistochemistry and immunofluorescence analyses, we validated the association of the identified molecule with clinical features and prognosis in an independent UCB cohort (n = 244) from SYMH. We also analysed TCGA‐BLCA cohort (n = 408) to identify its potential biological pathways and immune landscape.ResultsIn our study, chitinase 3‐like 1 (CHI3L1) emerged as a significantly overexpressed proinflammatory mediator in UCB tissues with lymphatic metastasis compared to those without lymphatic metastasis (81.1% vs. 47.8%, P < 0.001). Within UCB tissues, CHI3L1 was expressed in both stromal cells (52.8%) and tumor cells (7.3%). Moreover, CHI3L1+ stromal cells, but not tumor cells, exhibited independent prognostic significance for both overall survival (P < 0.001) and recurrence‐free survival (P = 0.006). CHI3L1+ stromal cells were positively associated with D2‐40+ lymphatic vessel density (P < 0.001) and the immunosuppressive PD‐L1/PD‐1/CD8 axis in UCB tissues (all P < 0.05). A bioinformatics analysis also identified a positive association between CHI3L1 expression and lymphangiogenesis or immunosuppression pathways.ConclusionOur study established a clear association between stromal CHI3L1 expression and lymphatic metastasis, suggesting that stromal CHI3L1 expression is a potential prognostic marker for bladder cancer patients.
Modeling habitat suitability for the lesser‐known populations of endangered mountain nyala (Tragelaphus buxtoni) in the Arsi and Ahmar Mountains, Ethiopia
Authors: Worku Ejigu Alemayehu , Evangelista Paul H. , Atickem Anagaw , Bekele Afework , Bro‐Jørgensen Jakob , Stenseth Nils Chr. 
Published: April 2024

AbstractHabitat suitability models have become a valuable tool for wildlife conservation and management, and are frequently used to better understand the range and habitat requirements of rare and endangered species. In this study, we employed two habitat suitability modeling techniques, namely Boosted Regression Tree (BRT) and Maximum Entropy (Maxent) models, to identify potential suitable habitats for the endangered mountain nyala (Tragelaphus buxtoni) and environmental factors affecting its distribution in the Arsi and Ahmar Mountains of Ethiopia. Presence points, used to develop our habitat suitability models, were recorded from fecal pellet counts (n = 130) encountered along 196 randomly established transects in 2015 and 2016. Predictor variables used in our models included major landcover types, Normalized Difference Vegetation Index (NDVI), greenness and wetness tasseled cap vegetation indices, elevation, and slope. Area Under the Curve model evaluations for BRT and Maxent were 0.96 and 0.95, respectively, demonstrating high performance. Both models were then ensembled into a single binary output highlighting an area of agreement. Our results suggest that 1864 km2 (9.1%) of the 20,567 km2 study area is suitable habitat for the mountain nyala with land cover types, elevation, NDVI, and slope of the terrain being the most important variables for both models. Our results highlight the extent to which habitat loss and fragmentation have disconnected mountain nyala subpopulations. Our models demonstrate the importance of further protecting suitable habitats for mountain nyala to ensure the species' conservation.