bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polystyrene Nanoplastics Disrupt Hepatic Vitellogenin Metabolism and Impair the Reproduction Process in Female Zebrafish
Authors: Mohammadzadeh Sedigheh , Zaretabar Amine , Ahmadifar Ehsan , Khajeh Mostafa , Moghadam Mohsen Shahriari , Milla Sylvain 
Published: February 2024

Abstract
For this study, 240 adult healthy female zebrafish were divided into 12 tanks (20 fish per tank) and exposed to 0 (control, T0), 0.1 (T1), 1 (T2), and 10 (T3) mg/L synthesized polystyrene nanoplastics (PS-NPs, nanoplastics synthesized in the chemistry laboratory of the Faculty of Basic Sciences at Zabol University) for 4 weeks. At the end of the experiment, exposure to PS-NPs had no significant effect on the survival of female zebrafish (P>0.05). A significant decrease of hepatic vitellogenin (Vtg) was seen in female zebrafish exposed to PS-NPs (P<0.05). The level of 17-β-estradiol (E2) and testosterone (T) were notably declined in female zebrafish of all PS-NPs-exposed groups (P<0.05). Glucose was notably increased in female zebrafish of all PS-NPs-exposed treatments (P<0.05). There was a significant increase in cortisol levels in all PS-NPs-exposed treatments (P<0.05). No significant difference was seen in lactate levels between different treatments (P>0.05). A significant enhancement in aspartate aminotransferase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) was observed in female zebrafish of all PS-NPs-exposed treatments compared to the control (P<0.05). The present results demonstrate that PS-NPs impair the reproduction process so that none of the female zebrafish broodstock exposed to different doses of PS-NPs reached the spawning stage.
Segmentasi Pelanggan B2B Berdasarkan Perilaku Pembelian dan Firmografi pada PT. Sukses Riau Permata (SRP)
Authors: Monalisa Siti , Nurahmah Novia 
Published: February 2024

Aset yang memberi pengaruh besar pada proses bisnis perusahaan retail adalah pelanggan. PT. Sukses Riau Permata (SRP) adalah badan usaha yang bergerak dalam bidang distribusi barang konsumsi yang pelanggannya banyak berjenis Business to Business (B2B). Permasalahan yang muncul pada PT. SRP ini adalah menurunnya jumlah konsumen sebanyak 27% yang terjadi pada 6 bulan terakhir Tahun 2021 dikarenakan strategi bisnis perusahaan belum mengaplikasikan Customer Relationship Management (CRM). PT. SRP belum mengidentifikasi pelanggan mana yang berkontribusi dan mana yang tidak memberikan keuntungan pada perusahaan akibatnya program pemasaran masih diberlakukan seragam kepada semua pelanggan. Maka dari itu pada penelitian ini dilakukan pengelompokan pelanggan berdasar kepada perilaku pembelian dan firmografi dengan algoritma Fuzzy C-Means. Indeks Davies Bouldin (DBI) digunakan untuk memverifikasi validitas hasil klasterisasi. Dari proses klasterisasi pelanggan dihasilkan 6 klaster yang dianalisis sesuai karakteristik segmen dengan segmen pelanggan terbaik yaitu cluster 4 (Superstar Segment) yang memiliki 383 pelanggan. Sedangkan segmen pelanggan terparah, yaitu cluster 6 (New Dormant Segment) yang memiliki 298 pelanggan. Adapun di akhir penelitian didapatkan hasil yaitu usulan strategi penjualan terbaik yang sesuai dengan deskripsi karakteristik dan kebutuhan segmen pelanggan.
The impact of omega-3 on recurrent seizures in epileptic patients: A case study with evidence-based approaches
Authors: Wijayanthie Nadiyah , Lestari Wiji 
Published: February 2024

Background: Epileptogenesis is also associated with increased production of excessive pro-inflammatory cytokines” which shows connection between pro-inflammatory cytokines as triggering factor with omega-3 which has anti-inflammatory effect. Omega-3, known for its neuroprotective and anticonvulsant properties, exhibits promising effects on epileptic seizure attacks.
Objective: This study aimed to evaluate the effect of omega-3 supplementation on the incidence of seizures in epilepsy patients.
Methods: This study used a literature search using advanced queries in the databases PubMed, Scopus, ProQuest, and Cochrane Library, and combined MeSH terms with Title/Abstract. The collected literature is discarded if there are duplicates, then literature is filtered that meets the eligibility criteria. We used the Oxford Center for Evidence-Based Medicine as a means of critical appraisal and determining the level of evidence of the selected literature.
Results: Four chosen literatures were critically assessed. Two articles indicating no significant difference between omega-3 and placebo and two articles showed had a significantly higher number of seizure-free days than placebo. The first article, involving 78 adults, reported a 50% reduction in seizure risk with a frequency RR of 0.57, 95% CI 0.19 to 1.75 (IS = 0%) indicating no significant difference between omega-3 and placebo groups after 12 weeks of treatment. The second study, comprising mostly non-significant findings, demonstrated no significant correlation between omega-3 and epilepsy attacks in epilepsy patients. The third literature revealed seizure occurrences per month in the EPA group (9.7±1.2), DHA group (11.7±1.5), and placebo group (16.6±1.5). Incidence rate ratio (IRR) adjusted for seizure type in EPA and DHA groups compared to the placebo group were 0.61 (CI = 0.42–0.88, p = 0.008, a 42% reduction) and 0.67 (CI = 0.46–1.0, p = 0.04, a 39% reduction), respectively. Both treatment groups had a significantly higher number of seizure-free days compared to the placebo group (p < 0.05). The fourth study reported intervention group frequency (4.72 ± 1.6, p= 0.014) and placebo frequency (11.64 ± 1.63, p=0.014) with intervention group seizure duration (6.64 ± 1.39, p=0.009) compared to placebo group (14.36 ± 2.18, p=0.009).
Conclusion: Omega-3 supplementation may be considered for management in patients with recurrent epileptic seizures, although its effect on reducing seizure frequency remains inconsistent.
EFEKTIVITAS PENGGUNAAN CELEBRITY DIPLOMACY BTS (BANGTAN SONYEONDAN) SEBAGAI GOODWILL AMBASSADOR UNICEF DALAM MELAKUKAN KAMPANYE ANTI-KEKERASAN “LOVE MYSELF”
Authors: Wahyuni Eny , Karjaya Lalu Puttrawandi , Husni Valencia 
Published: February 2024

Kekerasan terhadap anak merupakan masalah besar yang masih kerap terjadi di seluruh bagian dunia, baik kekerasan secara online (cyber bullying) maupun kekerasan yang terjadi secara langsung. Masalah tersebut menjadi tanggung jawab seluruh pihak, baik pemerintah, organisasi, masyarakat, dan pihak-pihak lainnya. Sehingga UNICEF sebagai organisasi internasional yang fokus pada pemberian bantuan dan solusi terhadap masalah anak dan remaja seluruh dunia berupaya menyelesaikan masalah tersebut. Salah satu upaya yang dilakukan UNICEF yaitu dengan menginisiasi diplomat selebritas yaitu BTS untuk bekerja sama dengan UNICEF dalam kampanye anti-kekerasan terhadap anak “Love Myself”.
Penelitian ini bertujuan untuk melakukan eskplorasi terkait dengan peran aktor non-negara dalam hal ini selebritas sebagai figur diplomasi yang memiliki andil yang cukup besar dalam mengkampanyekan isu anti-kekerasan terhadap anak. Lebih fokus lagi tulisan ini ingin melihat tentang sejauh mana BTS sebagai celebrity diplomacy mampu mendapatkan perhatian dunia dengan slogan kampanye yang mereka bawakan “Love Myself” Bersama UNICEF, dan bagaimana upaya yang dilakukan untuk meningkatkan kesadaran publik mengenai kekerasan terhadap anak agar dapat mengurangi kesenjangan dan angka kekerasan terhadap anak secara global. Penelitian ini menggunakan konsep Celebrity Diplomacy, konsep Organisasi Internasional, dan teori Efektivitas Rezim. Penelitian ini merupakan penelitian deskriptif. Hasil penelitian ini menunjukkan bahwa Kampanye Love Myself bernilai efektif dalam menyebarkan pesan-pesan positif untuk mencintai diri sendiri dan mengurangi angka kekerasan terhadap anak, serta berhasil mengumpulkan banyak dana dari berbagai program kerja atau kegiatan yang diinisiasi oleh UNICEF bersama BTS, yang mana akan digunakan seluruhnya untuk kebutuhan kampanye tersebut.
Implementing A Digital Health Navigator: Strategies & Experience in The Hospital Setting to alleviate Digital Equity
Authors: Saiyed, MD, MBA Salim , Ng, MD Wern Lynn , Cherry Madeline , Khattab Safi , Pathan Hafsa 
Published: February 2024

Background: The implementation of telemedicine and digital health technologies in healthcare has increased, but patients still need help adopting and utilizing these technologies. To address this, a Digital Health Navigator (DHN) program was implemented to evaluate the benefits of improving patients’ adoption.
Objectives: To alleviate digital equity within hospitals, we introduced a holistic digital health navigator program designed to promote the utilization of digital tools among hospitalized patients. To implement a DHN program to improve patient adoption of digital portals to engage in healthcare. To learn from the program to further develop patient-facing portal education for hospitalized patients to expand to other hospitals.
Methods: Over a period of thirty days, the DHN program conducted patient visits in two hospitals, on portal usage, collecting data, and adapting protocols based on patient feedback.
Results: Feedback from patients indicated 98% of patients found the education and the DHN to be helpful. 92% recommend the UPMC Central PA Portal for accessing their healthcare information. The DHN program proves beneficial in promoting portal usage and addressing technological barriers experienced by patients. We provide strategies and recommendations on how to implement such a program.
Discussion: We successfully implemented a digital health navigator program for hospitalized patients across two hospitals. Patients reported a positive perception and satisfaction with digital health navigator visits . Notably, our model overcomes challenges related to limited internet access and mitigates technology-related anxiety during hospital stays. The DHN program proved beneficial in promoting hospital portal usage and addressing technological barriers experienced by patients. Implementation and sustained adoption of digital technologies across a large healthcare organization can be achieved through a well-coordinated, team-based, and systematic approach with a DHN. We provide strategies and recommendations on how to implement such a program
PROTOTIPE SISTEM KONTROL SUARA DAN MONITORING PADA PINTU PAGAR BERBASIS IOT MENGGUNAKAN NODEMC ESP8266
Authors: Lenni Lenni , Rifa’i Muhamad Azis Rizal 
Published: February 2024

Pada umumnya pintu pagar masih banyak digunakan secara manual untuk membuka dan menutupnya.Tetapi dibeberapa tempat ada yang sudah mengontrolnya dengan cara menggunakan remote kontrol, mengirim SMS danvoice control di smartphone untuk membuka dan menutup pintu pagarnya. Tetapi disistem ini masih memiliki kekurangan. Dari kekurangan tersebut dibuatlah alat “Prototipe Sistem Kontrol Suara Dan Monitoring Pada Pintu Pagar Berbasis IoT Menggunakan Node MCU ESP8266”. Alat ini menggunakan module wifi Node MCU ESP8266 sebagai pengendalinya, smartphone sebagai pemberi perintahnya, motor dc sebagai penggerak pintu pagarnya, sensorphotoelectric sebagai sensor safety dan motor servo sebagai penggerak penguncinya. Metode yang digunakan yaitu eksperimen. Hasilnya pada pengujian pertama, kedua dan ketiga didapatkan rata – rata durasinya yaitu untuk membuka pintu pagar yaitu 40.04 detik, menutup pintu pagar yaitu 39.63 detik, membuka pengunci pintu pagar yaitu 8.3 detik dan menutup pengunci pintu pagar yaitu 7.51 detik. Sensor photoelectric juga berfungsi dengan baik ketika pintu pagar bergerak untuk menutup dan terdapat objek didepannya, pintu pagar secara langsung berhenti dan buzzer on dan bergerak kembali saat didepannya sudah tidak ada yang menghalangi. Hasil pengujian juga menunjukkan antarmuka monitoring dapa tmenampilkan realtime buka tutup pintu dan pengunci pagar.
Rancang Bangun Otomasi Penyiram Tanaman Berbasis Arduino Uno dan Liquid Cristal Display
Authors: Ridwan Taufik , Mawardi Ahmad 
Published: February 2024

Perkembangan teknologi saat ini mempermudah manusia termasuk dalam bidang pertanian, seperti untuk mengendalikan kelembaban tanah tanaman dan suhu udara oleh karena itu, tujuan penelitian ini adalah merancng bangun alat penyiram tanaman otomatis berdasarkan kelembaban tanah dan suhu udara, sehingga efisiensi waktu dan tenaga sebagai pertimbangan dalam bercocok tanam. Penelitian ini dilakukan dengan cara merakit komponen-komponen sistem yang meliputi sensor kelembaban tanah, sensor suhu udara, relay, LCD dan pompa air. Sensor Soil moisture (YL-69) sebagai pendeteksi tingkat kelembaban tanah dan suhu udara (DHT11) yang berfungsi sebagai pendeteksi suhu udara dan mengirim perintah kepada Arduino uno untuk menghidupkan driver relay agar Water Pump dapat menyiram air sesuai kebutuhan secara otomatis dan hasil pengukuran sensor yang didapat akan ditampilkan pada Liquit Cristal Display (LCD) dalam bentuk huruf dan angka. Hasil penelitian membuktikan alat dapat berfungsi apabila kelembaban tanah lebih dari 350RH dan suhu udara lebih dari 30ºC (High) maka pompa air On 5 detik secara terus menerus dan tidak berfungsi apabila kelembaban tanah kurang dari 350 RH serta suhu udara kurang dari 28ºC (Low).Kata kunci: Penyiram tanaman otomatis, Liquid Cristal Display, Soil Moisture YL-69, DHT11, Arduino Uno.
Ishmael at the Table of Abraham
Authors: Allen Andrea S. 
Published: February 2024

Abstract
Afro-Brazilian LGBTQ evangelicals stand betwixt and between as negotiators with evangelical and LGBTQ communities in Brazilian society. Finding full acceptance in neither community, these religious actors engage in interpretive endeavors that represent the ‘wonky’ potentiality of ‘Black queer religious hermeneutics’. At a LGBTQ-led evangelical church in São Paulo, Brazil, Afro-Brazilian believers’ theological orientations reveal how they can disturb queer theoretical frameworks that emphasize ‘resistance’ and ‘empowerment’. Such emphases can foreclose analytical possibilities in a myopic attempt to focus on queerness as the orienting experiential framework of sexual and gender minorities. Instead, this article offers the possibility for understanding the roles of religiosity and materiality as the primary grounds of analysis, eschewing an overreliance on abstraction and subversion as analytical frames.
Phân tích tĩnh phi tuyến hình học và vật liệu cấu kiện dầm-cột ống thép tròn nhồi bê tông
Authors: Danh Nguyễn Thế , Nghiêm Đoàn Ngọc Tịnh , Quy Phan Thị Tường , Lan Nguyễn Thị Tố , Hiếu Nguyễn Văn , Cường Ngô Hữu 
Published: February 2024

Dầm-cột ống thép tròn nhồi bê tông (CFST) là cấu kiện kết cấu có nhiều đặc điểm nổi trội cho kết cấu nhà nhiều tầng do có cường độ, độ cứng và độ dẻo dai cao hơn những loại cấu kiện thông thường trong khi có hình dáng kiến trúc thanh mảnh, có khả năng chống cháy tốt và thuận tiện cho thi công. Bài báo này phát triển một chương trình phân tích phi tuyến bằng ngôn ngữ lập trình Matlab để dự đoán ứng xử kết cấu của cấu kiện dầm-cột CFST cường độ cao dưới tác dụng của tải trọng nén lệch tâm có kể đến tác động bó lõi bê tông của ống thép và sự không hoàn hảo ban đầu về hình học của cấu kiện dầm-cột. Tiết diện liên hợp của cấu kiện dầm-côt được chia ̣thành nhiều điểm thớ thép và bê tông và trạng thái của tiết diện được cập nhật trong suốt quá trình phân tích để kể đến tác động phi đàn hồi kết hợp với sự xem xét tác động phi tuyến hình học giữa hai đầu cấu kiện. Những kết quả phân tích số đạt được từ chương trình phát triển được so sánh với các kết quả của các nghiên cứu khác chứng tỏ rằng nó là một công cụ mô phỏng khá hiệu quả và tương đối chính xác trong việc dự đoán khả năng chiu lư c của cấu kiện dầm-cột CFST tròn nhồi bê tông cường độ cao chịu tải trọng tĩnh trong nghiên cứu và thiết kế kỹ thuật.
The Assessment of Hapanasan Hot Spring Nature Tourism Based on the Analysis of Working Areas for Nature Tourism Objects and Attractions
Authors: Siti Kholizah  , Rahmawaty  , Hamdani Harahap  , Mohd Hasmadi Ismail  
Published: February 2024

Hapanasan Hot Spring Nature Tourism (HHSNT) is located in Rambah Tengah Baru Village, Rambah Sub-district, Rokan Hulu District, Riau Province. The area of HHSNT is 9 ha. This research aims to identify existing facilities in this area and assess the attractiveness, accessibility, environmental conditions, accommodation, infrastructure, and availability of clean water at this nature tourist location. In-depth interviews were conducted with 13 key informants. Direct observation was carried out by systematically observing and recording this region's potential nature tourist attractions. The analysis of working areas for nature tourism objects and attractions (Analisis Daerah Operasi-Objek Daya Tarik Wisata Alam/ADO-ODTWA) is used to determine the feasibility value of this tourist attraction. The results of this research show that the criteria value for attractiveness is 83.33%, the criteria for accessibility is 95.83%, the criteria for accommodation is 83.33%, the criteria for supporting facilities and infrastructure is 80%, the criteria for availability of clean water is 73.88%, and the criteria for socio-economic environmental conditions is 66.66%. Overall, the HHSNT area is worthy of development, with a percentage of 80.50%. The development of HHSNT can bring numerous benefits to the community, economy, and environment of Rokan Hulu. It can contribute to sustainable development while preserving the region's nature and cultural heritage for future generations
economía latinoamericana enfrentando el futuro: dominando lo probable y gestionando lo impredecible
Authors: Casilda Béjar Ramón 
Published: February 2024

La economía latinoamericana presenta una situación no muy diferente a la que ofrece la economía mundial: permanece en una senda de bajo crecimiento y no acaba de arrancar, ni de remontar el vuelo, y esto a pesar de contener y moderar la inflación.
La región se encuentra ante el cambio, la inestabilidad y la complejidad que presenta el mundo marcado por las tensiones geopolíticas generadas por la guerra en Ucrania y el conflicto en Oriento Medio –sin descartar la llegada de un cisne negro propio de la región–, los altos niveles de deuda e inflación, la subida del precio de los alimentos, la energía, el endurecimiento de los mercados de crédito, que presagian altos costos de financiamiento, en un entorno económico donde persiste el bajo crecimiento. Este escenario, enmarcado en el proceso de cambio climático, supone períodos de crecimiento cortos, frágiles y muy vulnerables, que constituyen, de hecho, situaciones difíciles de manejar.
The Making of the Modern Child: Children’s Literature and Childhood in the Late Eighteenth Century
Authors: O'Malley Andrew 
Published: February 2024

<p>This book explores how the concept of childhood in the late 18th century was constructed through the ideological work performed by children's literature, as well as pedagogical writing and medical literature of the era. Andrew O'Malley ties the evolution of the idea of "the child" to the growth of the middle class, which used the figure of the child as a symbol in its various calls for social reform.</p>
Effect of fertilizer composition and different varieties on yield, methane and nitrous oxide emission from rice field in East Java Indonesia
Authors: Slameto  , Fahrudin Danil Eka , Saputra Muhamad Wahyu 
Published: February 2024

IntroductionRice, as a staple food in several Asian countries, contributes to approximately 10% of greenhouse gas (GHG) emissions during its cultivation. Furthermore, nitrogen fertilization increases the accumulation of GHG emissions. This study aims to investigate GHG emissions, including methane (CH4) and nitrous Oxide (N2O) resulting from the common fertilizer variations used by farmers in Indonesia for two rice varieties, Way Apo Buru and Inpari 32, and their relationship to rice yield. MethodsThe research was conducted from August to November 2022 in an open field located in Jember, Indonesia. Two rice varieties, Inpari 32 and Way Apo Buru, were employed in this study. Fertilization variations included Urea (46%-N), ZA (21%-N 24%-S), SP-36 (36%-P &amp; 5%-S), KCl (250:100:50:50 kg ha-1) (P1); NPK (16%-N:16%-P:16%-K), Urea (46%-N), ZA (21%-N &amp; 24%-S) (225:175:100 kg ha-1) (P2); NPK (12%-N:12%-P:17%-K), Urea (46%-N), ZA (21%-N &amp; 24%-S) (175:150:100 kg ha-1) (P3); and NPKS (P1) + chicken manure fertilizer 5 tonnes ha-1 (P4).ResultsIn this research, Inpari 32 rice achieved greater yields while also exhibiting higher global warming potential. Applying NPKS fertilizer in combination with 5 tonnes ha-1 of manure fertilizer (referred to as P4) resulted in a substantial increase in rice yield compared to alternative fertilizer formulations. DiscussionsThe various inorganic fertilizers had a relatively similar influence on growth, production yield, and greenhouse gas emissions (CH4 and N2O). However, the fertilizer NPKS and 5 tonnes manure fertilizer resulted in the lowest CH4 emissions and global warming potential values.
Elucidating the anti-hypertensive mechanisms of Uncaria rhynchophylla-Alisma plantago-aquatica L: an integrated network pharmacology, cluster analysis, and molecular docking approach
Authors: Yin Tong , Zhang Han , Liu Xingfang , Wei Dongfeng , Ren Cong , Cui Liangyu , Li Yukun , Wang Linshuang , Wang Jiaheng , Zhao Zhiwei , Liu Dasheng , Wang Liying , Han Xuejie 
Published: February 2024

Background: With the increasing global prevalence of hypertension, a condition that can severely affect multiple organs, there is a growing need for effective treatment options. Uncaria rhynchophylla-Alisma plantago-aquatica L. (UR-AP) is a traditional drug pair used for treating hypertension based on the liver-kidney synergy concept. However, the detailed molecular mechanisms underlying its efficacy remain unclear.Methods: This study utilized an integrative approach combining network pharmacology, cluster analysis, and molecular docking to uncover the bioactive components and targets of UR-AP in the treatment of hypertension. Initially, we extracted data from public databases to identify these components and targets. A Protein-Protein Interaction (PPI) network was constructed, followed by enrichment analysis to pinpoint the bioactive components, core targets, and pivotal pathways. Cluster analysis helped in identifying key sub-networks and hypothesizing primary targets. Furthermore, molecular docking was conducted to validate the interaction between the core targets and major bioactive components, thus confirming their potential efficacy in hypertension treatment.Results: Network pharmacological analysis identified 58 bioactive compounds in UR-AP, notably quercetin, kaempferol, beta-sitosterol (from Uncaria rhynchophylla), and Alisol B, alisol B 23-acetate (from Alisma plantago-aquatica L.), as pivotal bioactives. We pinpointed 143 targets common to both UR-AP and hypertension, highlighting MAPK1, IL6, AKT1, VEGFA, EGFR, and TP53 as central targets involved in key pathways like diastolic and endothelial function, anti-atherosclerosis, AGE-RAGE signaling, and calcium signaling. Cluster analysis emphasized IL6, TNF, AKT1, and VEGFA’s roles in atherosclerosis and inflammation. Molecular docking confirmed strong interactions between these targets and UR-AP’s main bioactives, underscoring their therapeutic potential.Conclusion: This research delineates UR-AP’s pharmacological profile in hypertension treatment, linking traditional medicine with modern pharmacology. It highlights key bioactive components and their interactions with principal targets, suggesting UR-AP’s potential as a novel therapeutic option for hypertension. The evidence from molecular docking studies supports these interactions, indicating the relevance of these components in affecting hypertension pathways. However, the study acknowledges its limitations, including the reliance on in silico analyses and the need for in vivo validation. These findings pave the way for future clinical research, aiming to integrate traditional medicine insights with contemporary scientific approaches for developing innovative hypertension therapies.