bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hematological and Plasma Biochemical Profile of Two Species of Freshwater Stingrays From the Amazon
Authors: Santos Marcio Quara Carvalho , Aride Paulo Henrique Rocha , Farias Flávia Dayane Felix , Oliveira Adriano Teixeira 
Published: March 2024

Abstract

The demand for fish by-products and the need for nutritionally adequate and less expensive The evaluation of hematological and plasma biochemical parameters and the subsequent establishment of reference intervals can facilitate the diagnosis of the health status of animals and contribute to animal production, management, and conservation of natural populations. This work aimed to determine the hematological parameters of wild specimens of the stingrays Potamotrygon motoro and Potamotrygon orbignyi from the lower Solimões River region, Amazonas, Brazil, establishing reference blood values. One hundred forty-one stingrays were captured, 92 specimens of P. motoro and 49 of P. orbignyi, of both sexes and at different stages of development (neonates and juveniles). Hematological and plasma biochemical parameters were determined according to the methodology recommended in the literature. No effect of sex was observed on the hematological parameters of juvenile animals for both species. P. motoro neonates presented a distinct hematological profile, with significantly lower hematocrit values, hemoglobin, number of erythrocytes, mean corpuscular hemoglobin concentration, monocytes, plasma glucose, total proteins, albumin, and globulin. On the other hand, total cholesterol and urea levels were significantly higher in this same group compared to juveniles of the same species. Comparison between species revealed lower values of triglycerides and total cholesterol in P. orbignyi of both sexes. Due to the lack of sex effect, data from males and females of each species were grouped to establish more robust hematological reference intervals. The results obtained are pioneering for these Amazonian species in whitewater environments and will serve as a basis for evaluating the health status of wild stingrays. They can identify hematological disorders and monitor the animals' physiological adaptations to environmental changes.
Interdependency analysis between Precipitation and Temperature in Bangladesh: A copula-based approach
Authors: Prodhan Md Mehedi Hasan , Islam Md. Bashirul 
Published: March 2024

Abstract

Climate change presents a significant challenge to global ecosystems and human well-being, primarily through alterations in temperature and precipitation patterns. Understanding the interdependence between these crucial climatic parameters is crucial for assessing the impacts of climate change, particularly on extreme events like floods and droughts. This study employed copula functions to model the joint distribution of temperature and precipitation, surpassing their individual marginal distributions. The findings revealed strong correlations, as indicated by Kendall's tau coefficients and Spearman's rank correlation coefficients, between precipitation and mean temperature (τ = 0.524, ρ = 0.7), precipitation and maximum temperature (τ = 0.306, ρ = 0.456), and precipitation and minimum temperature (τ = 0.645, ρ = 0.795) at the 1% level of significance. Precipitation and minimum temperature both showed a marginal distribution of generalized Pareto, whereas mean temperature and maximum temperature showed marginal distributions of generalized extreme value and Weibull, respectively. Despite differing marginal distributions, copula modeling enables the establishment of a joint distribution. Among the copula functions tested, the Clayton copula emerges as the most suitable, exhibiting minimal AIC, BIC, RMSE, and maximal log-likelihood (LL) for all temperature (mean, maximum, and minimum) types. Overall, this study emphasizes the utility of copula-based approaches in analyzing the complex interdependence of climatic variables and their implications for climate change assessment and extreme event analysis.
Cause analysis and nursing experience of a case of thrombus on Eustachian valve after PICC catheterization
Authors: Ye Guan-Jun , Zhu Qian-Ru , Yu Yan-Fen , Wang Chun-Ying , Hu Su-Pei , Zhou Qin , He Juan 
Published: March 2024

Abstract

In this article, we have summarized and analyzed the causes and nursing experience of thrombosis on the eustachian valve in the right atrium of a patient with advanced gastric cancer during chemotherapy after PICC insertion. The nursing points included organizing multi-disciplinary joint consultation, vigilance against pulmonary embolism, nursing with anticoagulant drugs, and individualized psychological nursing. Finally, after 22 days of active treatment, the thrombus almost disappeared.
Electrotherapy; a promising therapy for virus eradication from olive shoot tip cultures cv. Meshkat
Authors: Mirzaei Leila , Yadollahi Abbas , Naderpour Masoud , Kermani Maryam Jafarkhani , Zeinanloo Ali Asghar , Eftekhari Maliheh , Eichmeier Ales 
Published: March 2024

Abstract

Olive tree harbors several viruses affecting the yield and quality of fruit worldwide. Application of virus-free planting materials is one of the main strategies to counteract virus diseases. The elimination ofArabis mosaic virus(ArMV), Cherry leaf roll virus(CLRV), Cucumber mosaic virus (CMV) and Strawberry latent ringspot virus(SLRSV) by different electrotherapies in combination with shoot tip culture was investigated in a native Iranian olive cultivar Meshkat to find out the most efficient virus elimination procedure. The results showed that survival, regrowth and proliferation rates were dependent on the therapy and meristem type. In addition, the regrowth rate in the virus mixed-infected cv. Meshkat was notably increased by doubling the electrotherapy duration. ArMV, CLRV, CMV and SLRSV were completely eradicated by electrotherapy treatment (35 mA, 100 V, 30 min) and the apical shoot tip culture proved to be the most compatible technique. The therapy efficiency index was 54 for all studied viruses. The results concluded that the combination of electrotherapy with shoot tip culture can be successfully used as a virus elimination method for producing virus-free olive plants.
A case of CLIPPERS with persistent CSF OCBs: where do the immunoglobulins come from?
Authors: Ren Jingru , Wang Jianchun , Niu Zhenyu , Liu Ran , Guo Jing , Yao Yan , Hao Hongjun , Gao Feng 
Published: March 2024

Abstract

Introduction: CLIPPERS is a rare inflammatory disorder of central nervous system characterized by significant involvement of the subtentorial region. There is a growing body of evidence suggesting a potential association between CLIPPERS and malignancies, specifically lymphoma. Some studies have proposed a role for Epstein Barr Virus in the pathogenesis of CLIPPERS, with the presence of CSF oligoclonal bands observed in certain cases.
Case presentation: A 39-year-old man presented with gait instability and cognitive impairment lasting proximately half a year following a respiratory tract infection. Pathogenic analysis identified the presence of Epstein-Barr virus in CSF. MRI revealed hyperintense lesions in the subcortical white matter, pontine and cerebellar regions, accompanied by perivascular contrast enhancement resembling a curvilinear, pepper-like pattern. Persistent oligoclonal bands (OCBs) in CSF have also been a notable characteristic. Biopsy results indicated a perivascular infiltration of T lymphocyte, ruiling out granulomas, vasculitis, or neoplasia. After excluding other potential diagnosis, the patient was ultimately diagnosed with CLIPPERS. Long term follow-up revealed persistent cerebrospinal fluid restricted oligoclonal bands and elevated protein. Conclusion: The presence of persistent of OCBs in patients with CLIPPERS may suggest a heightened B cell activation milieu and a history of prior infections. Given the elevated risk of malignant transformation, long-term monitoring is imperative for CLIPPERS patients, especially those with Epstein-Barr virus infection.
Short term prediction of water level based on deep learning during the flood season, in the downstream area of The Three Gorges Reservoir
Authors: Mao Xianghu , Xiong Biao , Li Tiantian , Luo Xin , Yao Zilin , Li Jianshe , Huang Yingping 
Published: March 2024

Abstract
Accurately predicting river water levels is crucial for managing water resources and controlling floods. In this study, we propose a water level prediction model based on a deep learning method (Transformer model) to improve the accuracy and efficiency of predicting inland river water levels. Water level data from seven hydrological stations were collected from the downstream area of the Three Gorges Reservoir, which confirmed the effectiveness of the model. the proposed model was improved by three main algorithms: the wavelet thresholding denoising (WTD) algorithm, the maximum information coefficient (MIC) algorithm, and the linear exponential (LIMEX) loss function. We are dedicated to improving the accuracy of predicting peak water levels during flood seasons. The results show that the proposed MIC-TF-LINEX model has achieved superior performance in predicting water levels compared to other models, such as traditional Transformer, Back Propagation (BP) Neural Network, and Bi-directional Long Short Term Memory (BILSTM). Furthermore, extending the forecast period will also affect the accuracy of the water level forecasting model. When the prediction duration is 8 hours, the R2 value is 0.9989, the MAE is 0.1020, the MSE is 0.0166, and the MAPE is 0.0060. When the prediction timeframe is within 56 hours, the MSE of the prediction result is still less than 0.1 meters. This study provides a highly accurate and well-suited method for predicting floods.
Tiramisù: Making Sense of Multi-Faceted Process Information Through Time and Space
Authors: Alman Anti , Arleo Alessio , Beerepoot Iris , Burattin Andrea , Ciccio Claudio Di , Resinas Manuel 
Published: March 2024

Abstract

Knowledge-intensive processes represent a particularly challenging scenario for process mining. The flexibility that such processes allow constitutes a hurdle as they are hard to capture in a single model. To tackle this problem, multiple visual representations of the same processes could be beneficial, each addressing different information dimensions according to the specific needs and background knowledge of the concrete process workers and stakeholders. In this paper, we propose, describe, and evaluate a framework, named Tiramisù, that leverages visual analytics for the interactive visualization of multi-faceted process information, aimed at supporting the investigation and insight generation of users in their process analysis tasks.
Tiramisù is based on a multi-layer visualization methodology that includes a visual backdrop that provides context and an arbitrary number of superimposed and on-demand dimension layers. This arrangement allows our framework to display process information from different perspectives and to project this information onto a domain-friendly representation of the context in which the process unfolds. We provide an in-depth description of the approach's founding principles, deeply rooted in visualization research, that justify our design choices for the whole framework. We demonstrate the feasibility of the framework through its application in two use-case scenarios in the context of healthcare and personal information management. Plus, we conducted qualitative evaluations with potential end users of both scenarios, gathering precious insights about the efficacy and applicability of our framework to various application domains.
Effect of Glomerular Filtration Rate on Uric Acid Metabolism in a Retrospective Cohort of Type-2 Diabetes Mellitus Patients on Sglt-2 Inhibitor Therapy
Authors: Vuraloglu Emre , Kut Altug , İyidir Özlem Turhan 
Published: March 2024

Abstract
Purpose
The study aims to investigate the effect of different glomerular filtration rates (GFR) on serum uric acid (SUA) level changes in Type-2 DM patients receiving SGLT-2 inhibitor therapy.
Methods
We investigated 3004 patients on SGLT-2 inhibitor treatment between January-2017 and September-2022. Patients who were taking irregular medication, did not attend follow-up visits, were taking medications that affected SUA levels, and were receiving gout treatment were excluded, leaving 410 patients in the sample after exclusions. Patients underwent measurement of blood and urine biochemical markers before SGLT-2 inhibitor treatment and at months 3 and 12. We divided the study group into 3 subgroups (GFR≥90, 60-89, 30-59 ml/min/1.73m2) according to the Kidney Disease Foundation for Improving Global Outcomes and analyzed the effects of SGLT-2 inhibitors on SUA levels according to GFR.
Results
The study group had a male:female ratio of 1.24:1 with a mean age of 59.1±11.55 years. When comparing before and after treatment, HbA1C, fasting blood glucose, creatinine, low-density lipoprotein cholesterol, triglycerides and SUA levels decreased significantly, while high-density lipoprotein cholesterol and urine glucose levels increased significantly. In patients with GFR between 30-59 ml/min/1.73m2, no significant difference was found between the SUA values at pre-drug, 3rd, and 12th month drug therapy (p=0.368), and the effect on SUA levels differed according to GFR. This effect was not depending on the active substance and we considered it as a group effect of SGLT-2 inhibitors. The uric acid lowering effect of SGLT-2 inhibitors tends to increase as GFR increases.
Conclusion
We demonstrated that SGLT-2 inhibitors are not only anti-diabetic drugs, but may also have a protective role against diseases associated with hyperlipidemia and hyperuricemia in patients with preserved GFR, while no such effect should be expected in patients with low GFR.
Temporal trends of the disease burden of renal cell carcinoma from 1992 to 2019 in the US: A population-based analysis
Authors: Chen Ruyan , Tang Tian , Han Jianglong , Li Si , Liu Wenmin , Deng Haiyu , Jian Tingting , Fu Zhenming 
Published: March 2024

Abstract
Purpose
Significant advances in the management, in particular the treatment, of renal cell carcinoma (RCC) has have been made over the years. However, it is not clear whether these advances reduce the disease burden of RCC at the population level.
Methods
Using data from the Surveillance, Epidemiology, and End Results database, we estimated the temporal trends of RCC incidence, incidence-based mortality (IBM), and survival rates in the United States (US) from 1992 to through 2019.
Results
From 2008 to 2019, the incidence increased slowly at 1.1% annually (95% CI: 0.6–1.5%). The overall IBM rate of RCC increased by 6.8% per year (95% CI: -1.1–15.3%) between 1994 and 1997, plateaued between 1997 and 2015, and then decreased nonsignificantly after 2015. During the study period, the overall 5-year survival rate of RCC continuously increased from 53.69% in 1992 to 72.90% in 2014, with the best improvement observed for RCC patients with distant disease. However, we projected that, given the current trends, the incidence of RCC in the US will continue to increase from 6.92 per 100,000 in 2015–2019 to 9.59 per 100,000 in 2040–2044.
Conclusion
Over the years, the mortality of RCC has been decreased reducing at the US populational level mainly because the considerably significantly improved survival of RCC patients at all stages through the advances in treatment. However, the overall incidence of RCC is continuously increasing, indicating that more effective preventive strategies should be developed to reduce the disease burden of RCC.
Evaluating the relationship between safety culture and the quality of patient handover between the ambulance and emergency department from the viewpoints of hospital emergency nurses and emergency medical personnel in northwest Iran
Authors: Alidokht Sevda , Mohamadi Mohammad Ail , Dadkhah Behrouz 
Published: March 2024

Abstract

Aims:The present study aimed to evaluate the relationship between safety culture and the quality of patient handover between the ambulance and emergency.Background:Evaluating the patient safety culture significantly affects the quality of patient handover, medical, and care services in different hospital units, especially the emergency department.Methods:The present correlational study was conducted on all nurses working in the emergency departments of educational-medical centers (N=220) and medical emergency personnel of Ardabil city (N=92) using the census method. The data were collected using the Leif et al. (2018) Hospital Survey on Patient Safety Questionnaire and the Golling et al. (2022) Quality of Patient Handover between Ambulance and Emergency Department Questionnaire. The collected data were analyzed in SPSS software (26) using descriptive statistics, independent t-test, analysis of variance, Pearson correlation coefficients, and linear regression logistic model.Results:The results revealed that the quality of patient safety culture in emergency nurses (90.5%) and emergency medical personnel (89.1%) was at a moderate level. The mean patient safety culture in emergency nurses (17.75±151.43) was higher than in emergency medical personnel (148.37±18.48) and this difference was statistically significant (P<0.04). The quality of patient handover among emergency nurses (71.7%) and emergency medical personnel (83.7%) was also moderate and it was statistically significant (P<0.04). There was a positive and significant correlation between the patient safety culture and the quality of patient handover between the ambulance and emergency department (P<0.01). The stepwise multiple linear regression model showed that "teamwork between organizational units" was a stronger predictor than other variables in the quality of patient handover between the ambulance and emergency department.Conclusion:The results revealed that by increasing the level of patient safety culture in emergency nurses, the quality of patient handover increases. Therefore, it is recommended that the policymakers in the health area take the necessary measures by holding briefing workshops to promote the culture of patient safety and strengthen teamwork among the emergency department personnel.
The use of patient-reported outcome measures to improve patient-related outcomes – a systematic review
Authors: Bonsel Joshua M. , Itiola Ademola J. , Huberts Anouk S. , Bonsel Gouke J. , Penton Hannah 
Published: March 2024

Abstract

Background
Patient-reported outcome measures (PROMs) provide invaluable information on patients’ health outcomes and can be used to improve patient-related outcomes at the individual, organizational and policy levels. This systematic review aimed to a) identify contemporary applications and synthesize all evidence on the use of PROMs in these contexts and b) to determine characteristics of interventions associated with increased effectiveness.
Methods
Five databases were searched for studies providing quantitative evidence of the impact of PROM interventions. Any study design was permitted. An overall benefit (worsening) in outcome was defined as a statistically significant improvement (deterioration) in either a PROM, patient-reported experience measure or clinical outcome. Study quality was assessed using the Effective Public Healthcare Panacea Project’s Quality Assessment Tool for Quantitative Studies. A narrative synthesis was conducted.
Results
Seventy-six studies of the 11,121 articles identified met the inclusion criteria. At the individual level, 10 (43%) of 23 studies that fed back PROMs to the patient or healthcare provider showed an improvement in outcome. This percentage increased in studies which used PROMs to monitor disease symptoms and linked these to care-pathways: 17 (68%) of 25 studies using this mechanism showed an improvement. Ten (71%) of 14 studies using PROMs to screen for disease found a benefit. The monitoring and screening approach was most effective using PROMs covering cancer-related, depression and gastro-intestinal symptoms. Three studies found that the mere collection of PROMs resulted in improved outcomes. Another three studies used PROMs in decision aids and found improved decision quality.
At the organizational/policy level, none of the 4 studies that used PROMs for benchmarking found a benefit. The three studies that used PROMs for in-depth performance analyses and 1 study in a plan-do-study-act (PDCA) cycle found an improvement in outcome.
Studies employing disease-specific PROMs tended to observe improved outcomes more often. There are concerns regarding the validity of findings, as studies varied from weak to moderate quality.
Conclusions
The use of PROMs at the individual level has matured considerably. Monitoring/screening applications seem promising particularly for diseases for which treatment algorithms rely on the experienced symptom burden by patients. Organizational/policy-level application is in its infancy, and performance evaluation via in-depth analyses and PDCA-cycles may be useful. The findings of this review may aid stakeholders in the development and implementation of PROM-interventions which truly impact patient outcomes.
Does bullying victimization accelerate adolescents’ non-suicidal self-injury? The mediating role of negation emotions and the moderating role of submissive behavior
Authors: Gao Ling , Zhang Zixi , Wu Xiani , Wang Xingchao 
Published: March 2024

Abstract

Based on general strain theory, the current study examined whether bullying victimization was significantly related to adolescents’ non-suicidal self-injury and whether negation emotions mediated this association and submissive behavior moderated this mediation process. A total of 1984 adolescents completed a series of anonymous questionaries regarding bullying victimization, negative emotions, non-suicidal self-injury, and submissive behavior. Results showed that bullying victimization was significantly and positively associated with non-suicidal self-injury and this relation was partially mediated by negative emotions. Submissive behavior moderated the relation between bullying victimization and non-suicidal self-injury as well as negation emotions and non-suicidal self-injury. Specifically, the victims of bullying with high submissive behavior were more likely to develop non-suicidal self-injury. Adolescents who had higher negative emotions were at greater risk of engaging in non-suicidal self-injury when they also had high submissive behavior. The positive association between negative emotions and non-suicidal self-injury was stronger in females than males.
Analysis of gap length as a predictor of surgical outcomes in esophageal atresia with distal fistula: a single center experience
Authors: Ishikawa Miki , Tomita Hirofumi , Ito Yoshifumi , Tsukizaki Ayano , Abe Kiyotomo , Shimotakahara Akihiro , Shimojima Naoki , Hirobe Seiichi 
Published: March 2024

Abstract
Purpose
Long-gap esophageal atresia (LGEA) is still a challenge for pediatric surgery. No consensus exists as to what constitutes a long gap, and few studies have investigated the maximum gap length safely repairable by primary anastomosis. Based on surgical outcomes at a single institution, we aimed to determine the gap length in LGEA with a high risk of complications.
Methods
The medical records of 51, consecutive patients with esophageal atresia (EA) with primary repair in the early neonatal period between 2001 and 2021 were retrospectively reviewed. Three, major complications were found in the surgical outcomes: 1) anastomotic leakage, 2) esophageal stricture requiring dilatation, and 3) GERD requiring fundoplication. The predictive power of the postsurgical complications was assessed using receiver operating characteristic analysis, and the area under the curve (AUC) and the cutoff value with a specificity of > 90% were calculated.
Results
Sixteen patients (31.4%) experienced a complication. The AUC of gap length was0.90 (p < 0.001), and the gap length cutoff value was ≥ 2.0 cm for predicting any complication (sensitivity: 62.5%, specificity: 91.4%).
Conclusion
A gap length ≥ 2.0 cm was considered as defining LGEA and was associated with an extremely high complication rate after primary repair.