bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hematite Frictional Behavior and He Loss From Comminution During Deformation Experiments at Slow Slip Rates
Authors: DiMonte A. A. , Ault A. K. , Hirth G. , Meyers C. D. 
Published: March 2024

AbstractDeformation experiments on hematite characterize its slip‐rate dependent frictional properties and deformation mechanisms. These data inform interpretations of slip behavior from exhumed hematite‐coated faults and present‐day deformation at depth. We used a rotary‐shear apparatus to conduct single‐velocity and velocity‐step experiments on polycrystalline specular hematite rock (∼17 μm average plate thickness) at slip rates of 0.85 μm/s to 320 mm/s, displacements of primarily 1–3 cm and up to 45 cm, and normal stresses of 5 and 8.5 MPa. The average coefficient of friction is 0.70; velocity‐step experiments indicate velocity‐strengthening to velocity‐neutral behavior at rates <1 mm/s. Scanning electron microscopy showed experimentally generated faults develop in a semi‐continuous, thin layer of red hematite gouge. Angular gouge particles have an average diameter of ∼0.7 μm, and grain size reduction during slip yields a factor of 10–100 increase in surface area. Hematite is amenable to (U‐Th)/He thermochronometry, which can quantify fault‐related thermal and mechanical processes. Comparison of hematite (U‐Th)/He dates from the undeformed material and experimentally produced gouge indicates He loss occurs during comminution at slow deformation rates without an associated temperature rise required for diffusive loss. Our results imply that, in natural fault rocks, deformation localizes within coarse‐grained hematite by stable sliding, and that hematite (U‐Th)/He dates acquired from ultracataclasite or highly comminuted gouge reflect minor He loss unrelated to thermal processes. Consequently, the magnitude of temperature rise and associated thermal resetting in hematite‐bearing fault rocks based on (U‐Th)/He thermochronometry may be overestimated if only diffusive loss of He is considered.
A Potential Vorticity Diagnosis of Tropical Cyclone Track Forecast Errors
Authors: Barbero Tyler W. , Bell Michael M. , Chen Jan‐Huey , Klotzbach Philip J. 
Published: March 2024

AbstractTropical cyclone (TC) track forecasting provides essential guidance for coastal communities. However, track forecast errors still occur, highlighting the need for continued research into error sources. Piecewise potential vorticity (PV) inversion is used systematically to quantitatively diagnose errors in track forecasts in four models during the 2017 Atlantic hurricane season. The deep layer mean steering flow (DLMSF) provides a sufficient proxy for hurricane movement, and DLMSF errors are correlated with TC track errors. Analysis of track forecasts for Hurricanes Harvey, Irma, and Maria reveals that their track errors are attributed to steering errors caused by misrepresentations of specific pressure systems. Harvey's westward track error in the GFS resulted from zonal wind errors from the Continental High, while Irma's northward track error in the SHiELD gfsIC resulted from meridional wind errors in the Bermuda High and Continental High. Maria's southward track error in the IFS resulted from meridional wind errors in the Bermuda High and a misrepresentation of Jose to Maria's northwest. The mean absolute error of the DLMSF shows that the Bermuda High contributed the most to steering flow errors in the cases examined. Our results show that piecewise PV inversion can identify the sources of biases in TC track forecasts. The correction of these biases may lead to improved track forecasts. Quantitative diagnostics presented here provide useful information for future model development.
NEAT1_1 confers gefitinib resistance in lung adenocarcinoma through promoting AKR1C1-mediated ferroptosis defence
Authors: Zhen Shuman , Jia Yunlong , Zhao Yan , Wang Jiali , Zheng Boyang , Liu Tianxu , Duan Yuqing , Lv Wei , Wang Jiaqi , Xu Fan , Liu Yueping , Zhang Yi , Liu Lihua 
Published: March 2024

AbstractGefitinib is one of the most extensively utilized epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) for treating advanced lung adenocarcinoma (LUAD) patients harboring EGFR mutation. However, the emergence of drug resistance significantly compromised the clinical efficacy of EGFR-TKIs. Gaining further insights into the molecular mechanisms underlying gefitinib resistance holds promise for developing novel strategies to overcome the resistance and improve the prognosis in LUAD patients. Here, we identified that the inhibitory efficacy of gefitinib on EGFR-mutated LUAD cells was partially dependent on the induction of ferroptosis, and ferroptosis protection resulted in gefitinib resistance. Among the ferroptosis suppressors, aldo-keto reductase family 1 member C1 (AKR1C1) exhibited significant upregulation in gefitinib-resistant strains of LUAD cells and predicted poor progression-free survival (PFS) and overall survival (OS) of LUAD patients who received first-generation EGFR-TKI treatment. Knockdown of AKR1C1 partially reversed drug resistance by re-sensitizing the LUAD cells to gefitinib-mediated ferroptosis. The decreased expression of miR-338-3p contributed to the aberrant upregulation of AKR1C1 in gefitinib-resistant LUAD cells. Furthermore, upregulated long non-coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1_1 (NEAT1_1) sponged miR-338-3p to neutralize its suppression on AKR1C1. Dual-luciferase reporter assay and miRNA rescue experiment confirmed the NEAT1_1/miR-338-3p/AKR1C1 axis in EGFR-mutated LUAD cells. Gain- and loss-of-function assays demonstrated that the NEAT1_1/miR-338-3p/AKR1C1 axis promoted gefitinib resistance, proliferation, migration, and invasion in LUAD cells. This study reveals the effects of NEAT1_1/miR-338-3p/AKR1C1 axis-mediated ferroptosis defence in gefitinib resistance in LUAD. Thus, targeting NEAT1_1/miR-338-3p/AKR1C1 axis might be a novel strategy for overcoming gefitinib resistance in LUAD harboring EGFR mutation.
Relatedness-based mate choice and female philopatry: inbreeding trends of wolf packs in a human-dominated landscape
Authors: Pacheco Carolina , Rio-Maior Helena , Nakamura Mónia , Álvares Francisco , Godinho Raquel 
Published: March 2024

AbstractInbreeding can reduce offspring fitness and has substantial implications for the genetic diversity and long-term viability of populations. In social cooperative canids, inbreeding is conditioned by the geographic proximity between opposite-sex kin outside natal groups and the presence of related individuals in neighbouring groups. Consequently, challenges in moving into other regions where the species is present can also affect inbreeding rates. These can be particularly problematic in areas of high human density, where movement can be restricted, even for highly vagile species. In this study, we investigate the socio-ecological dynamics of Iberian wolf packs in the human-dominated landscape of Alto Minho, in northwest Portugal, where wolves exhibit a high prevalence of short-distance dispersal and limited gene flow with neighbouring regions. We hypothesise that mating occurs regardless of relatedness, resulting in recurrent inbreeding due to high kin encounter rates. Using data from a 10-year non-invasive genetic monitoring programme and a combination of relatedness estimates and genealogical reconstructions, we describe genetic diversity, mate choice, and dispersal strategies among Alto Minho packs. In contrast with expectations, our findings reveal relatedness-based mate choice, low kin encounter rates, and a reduced number of inbreeding events. We observed a high prevalence of philopatry, particularly among female breeders, with the most common breeding strategy involving the pairing of a philopatric female with an unrelated immigrant male. Overall, wolves were not inbred, and temporal changes in genetic diversity were not significant. Our findings are discussed, considering the demographic trend of wolves in Alto Minho and its human-dominated landscape.
Multi-omics dataset of bovine mammary epithelial cells stimulated by ten different essential amino acids
Authors: Xu Lianbin , Wang Xiaowen , Li Xiuli , Liu Huawei , Zhao Jinshan , Bu Dengpan 
Published: March 2024

AbstractApplication of high-throughput sequencing and screening help to detect the transcriptional and metabolic discrepancies in organs provided with various levels of nutrients. The influences of individual essential amino acid (EAA) administration on transcriptomic and metabolomic profilings of bovine mammary epithelial cells (BMECs) were systematically investigated. A RNA sequencing and liquid chromatography-tandem mass spectrometry generated a comprehensive comparison of transcriptomics, non-targeted metabolomics and targeted amino acids profilings of BMECs with individual EAA stimulation by turn. The sequencing data and raw LC-MS/MS data of samples were presented in the databases of Gene Expression Omnibus, MetaboLights and Figshare for efficient reuse, including exploring the divergences in metabolisms between different EAAs and screening valuable genes and metabolites regulating casein synthesis.
Cluster analysis of patient characteristics, treatment modalities, renal impairments, and inflammatory markers in diabetes mellitus
Authors: Cojic Milena , Klisic Aleksandra , Sahmanovic Amina , Petrovic Nemanja , Kocic Gordana 
Published: March 2024

AbstractType 2 diabetes mellitus (T2DM) is caused by an interplay of various factors where chronic hyperglycemia and inflammation have central role in its onset and progression. Identifying patient groups with increased inflammation in order to provide more personalized approach has become crucial. We hypothesized that grouping patients into clusters according to their clinical characteristics could identify distinct unique profiles that were previously invisible to the clinical eye. A cross-sectional record-based study was performed at the Primary Health Care Center Podgorica, Montenegro, on 424 T2DM patients aged between 30 and 85. Using hierarchical clustering patients were grouped into four distinct clusters based on 12 clinical variables, including glycemic and other relevant metabolic indicators. Inflammation was assessed through neutrophil-to-lymphocyte (NLR) and platelet to lymphocyte ratio (PLR). Cluster 3 which featured the oldest patients with the longest T2DM duration, highest hypertension rate, poor glycemic control and significant GFR impairment had the highest levels of inflammatory markers. Cluster 4 which featured the youngest patients, with the best glycemic control, the highest GFR had the lowest prevalence of coronary disease, but not the lowest levels of inflammatory markers. Identifying these clusters offers physicians opportunity for more personalized T2DM management, potentially mitigating its associated complications.
Impact of enriched environment on motor performance and learning in mice
Authors: Dijkhuizen S. , Van Ginneken L. M. C. , IJpelaar A. H. C. , Koekkoek S. K. E. , De Zeeuw C. I. , Boele H. J. 
Published: March 2024

AbstractNeuroscience heavily relies on animal welfare in laboratory rodents as it can significantly affect brain development, cognitive function and memory formation. Unfortunately, laboratory animals are often raised in artificial environments devoid of physical and social stimuli, potentially leading to biased outcomes in behavioural assays. To assess this effect, we examined the impact of social and physical cage enrichment on various forms of motor coordination. Our findings indicate that while enriched-housed animals did not exhibit faster learning in eyeblink conditioning, the peak timing of their conditioned responses was slightly, but significantly, improved. Additionally, enriched-housed animals outperformed animals that were housed in standard conditions in the accelerating rotarod and ErasmusLadder test. In contrast, we found no significant effect of enrichment on the balance beam and grip strength test. Overall, our data suggest that an enriched environment can improve motor performance and motor learning under challenging and/or novel circumstances, possibly reflecting an altered state of anxiety.
Mental health and psychosocial interventions in the context of climate change: a scoping review
Authors: Xue Siqi , Massazza Alessandro , Akhter-Khan Samia C. , Wray Britt , Husain M. Ishrat , Lawrance Emma L. 
Published: March 2024

AbstractThe evidence on the impacts of climate change on mental health and wellbeing is growing rapidly. The objective of this scoping review is to understand the extent and type of existing mental health and psychosocial interventions aimed at addressing the mental health and psychosocial impacts of climate change. A scoping review methodology was followed. MEDLINE, PsycINFO, and Web of Science databases were searched from inception to May 2022. Comprehensive gray literature search, including expert consultation, was conducted to identify interventions for which peer-reviewed academic literature may not yet be available. Data on intervention type, setting, climate stressor, mental health outcome, evaluation, and any other available details were extracted, and results were summarized narratively. Academic literature search identified 16 records and gray literature search identified a further 24 records. Altogether, 37 unique interventions or packages of interventions were identified. The interventions act at the levels of microsystem, mesosystem, exosystem, and macrosystem through diverse mechanisms. While most interventions have not been formally evaluated, promising preliminary results support interventions in low- and middle-income-country settings disproportionately affected by climate disasters. Interventions from multidisciplinary fields are emerging to reduce psychological distress and enhance mental health and wellbeing in the context of climate change. This scoping review details existing evidence on the interventions and summarizes intervention gaps and lessons learned to inform continued intervention development and scale-up interventions.
Anomalous hall and skyrmion topological hall resistivity in magnetic heterostructures for the neuromorphic computing applications
Authors: Lone Aijaz H. , Zou Xuecui , Das Debasis , Fong Xuanyao , Setti Gianluca , Fariborzi Hossein 
Published: March 2024

AbstractTopologically protected spin textures, such as magnetic skyrmions, have shown the potential for high-density data storage and energy-efficient computing applications owing to their particle-like behavior, small size, and low driving current requirements. Evaluating the writing and reading of the skyrmion’s magnetic and electrical characteristics is crucial to implementing these devices. In this paper, we present the magnetic heterostructure Hall bar device and study the anomalous Hall and topological Hall signals in these devices. Using different measurement techniques, we investigate the magnetic and electrical characteristics of the magnetic structure. We measure the skyrmion topological resistivity and the magnetic field at different temperatures. MFM imaging and micromagnetic simulations further explain the anomalous Hall and topological Hall resistivity characteristics at various magnetic fields and temperatures. The study is extended to propose a skyrmion-based synaptic device showing spin-orbit torque-controlled plasticity. The resistance states are read using the anomalous Hall measurement technique. The device integration in a neuromorphic circuit is simulated in a 3-layer feedforward artificial neural network ANN. Based on the proposed synapses, the neural network is trained and tested on the MNIST data set, where a recognition accuracy performance of about 90% is achieved. Considering the nanosecond reading/writing time scale and a good system level performance, these devices exhibit a substantial prospect for energy-efficient neuromorphic computing.
Effects of Age on the Frequency Amplitude Ratio of Cervical and Ocular Vestibular Evoked Myogenic Potentials
Authors: Jha Raghav H. , Piker Erin G. , Gomez Jesus 
Published: March 2024

Purpose:
An increase in the 1000/500 Hz frequency amplitude ratio (FAR) of the cervical and ocular vestibular evoked myogenic potentials (cVEMP and oVEMP, respectively) may serve as a potential biomarker for diagnosing Meniere's disease (MD). However, the aging process can also result in an increased FAR for VEMPs. In older patients, distinguishing whether changes in VEMP FAR are due to MD or aging processes becomes difficult. We aimed to investigate the effects of age on VEMP FARs and establish a FAR-normative range for different age groups.

Method:
cVEMP and oVEMP were recorded from a total of 106 participants grouped as young, middle-aged, and older adults using air-conducted tone bursts at 500, 750, and 1000 Hz at 125 dB pSPL. The FAR was calculated for the cVEMP and oVEMP for the following frequencies: FAR1 = 1000/500, FAR2 = 1000/750, and FAR3 = 750/500.

Results:
A significant age-related effect was observed on the cVEMP FAR. Although the oVEMP FAR showed an increasing trend with age, it was not statistically significant. Age-based normative FAR values are provided.

Conclusions:
Drawing from the normative FAR from this study, there is evidence that the existing MD diagnostic criteria would misidentify a considerable number of older adults. Therefore, to reduce false positives, we recommend a more stringent cVEMP and oVEMP FAR criterion in older adults.
Mandarin-Speaking Amusics' Online Recognition of Tone and Intonation
Authors: Tang Lirong , Xu Yangxiaoxue , Yang Shiting , Meng Xiangyun , Du Boqi , Sun Chen , Liu Li , Dong Qi , Nan Yun 
Published: March 2024

Purpose:
Congenital amusia is a neurogenetic disorder of musical pitch processing. Its linguistic consequences have been examined separately for speech intonations and lexical tones. However, in a tonal language such as Chinese, the processing of intonations and lexical tones interacts with each other during online speech perception. Whether and how the musical pitch disorder might affect linguistic pitch processing during online speech perception remains unknown.

Method:
We investigated this question with intonation (question vs. statement) and lexical tone (rising Tone 2 vs. falling Tone 4) identification tasks using the same set of sentences, comparing behavioral and event-related potential measurements between Mandarin-speaking amusics and matched controls. We specifically focused on the amusics without behavioral lexical tone deficits (the majority, i.e., pure amusics).

Results:
Results showed that, despite relative to normal performance when tested in word lexical tone test, pure amusics demonstrated inferior recognition than controls during sentence tone and intonation identification. Compared to controls, pure amusics had larger N400 amplitudes in question stimuli during tone task and smaller P600 amplitudes in intonation task.

Conclusion:
These data indicate that musical pitch disorder affects both tone and intonation processing during sentence processing even for pure amusics, whose lexical tone processing was intact when tested with words.
Language Assessment in Bilingual Turkish-Speaking Preschoolers With Developmental Language Disorders: A Tutorial
Authors: Saban-Dülger Nur Seda , Özcebe Esra 
Published: March 2024

Purpose:
Developmental language disorder (DLD) is a common childhood disorder that hinders children from functioning in other developmental areas, such as social–emotional and cognitive domains. Consequently, a comprehensive speech and language assessment of children is of great importance. Of concern, however, is the challenge for speech and language pathologists to assess the speech and language skills of bilingual children. This article aims to inform clinicians, researchers, and other experts working with bilingual Turkish-speaking children with DLD about bilingual language assessment.

Method:
The current literature on Turkish–English bilingual language acquisition and bilingual language assessment is reviewed, and the general characteristics of bilingual development are reported. In order to understand how the first language affects the second language, a contrastive analysis of the Turkish and English languages is summarized. A case study is described to highlight essential factors to take into account when creating a comprehensive language assessment battery for Turkish, covering all areas impacted by DLD.

Results:
The results of the proposed language assessment protocol are analyzed, and its practical use is discussed. Additionally, the case study child's strengths and the skills requiring support are interpreted with regard to their implications for daily life activities and prospective academic requirements.

Conclusions:
This tutorial highlights the importance of comprehensive language assessment for the differential diagnosis of DLD in bilinguals as the most essential step to develop an appropriate intervention program and counseling procedures. Such assessment considers individual as well as cultural differences of children and their family members.
Pediatric Medical Traumatic Stress in Individuals With Craniofacial Conditions
Authors: Crerand Canice E. , Billaud Feragen Kristin , Johns Alexis L. , Umbaugh Hailey , McClinchie Madeline , Drake Amelia F. , Heike Carrie L. , Yi-Frazier Joyce P. , Stock Nicola M. 
Published: March 2024

Purpose:
This article reviews the literature focused on the psychological effects of craniofacial care for patients and their families. It provides an overview of pediatric medical traumatic stress (PMTS) associated with craniofacial conditions and related care, along with a review of its risk and protective factors. Findings from studies of PMTS in craniofacial populations are also reviewed.

Conclusions:
The article concludes with strategies for identifying, addressing, and preventing medical traumatic stress in the context of craniofacial care. Specific implications for speech-language pathologists are also shared with respect to ways of minimizing risks for medical traumatic stress in craniofacial care. Future directions are also delineated and include strategies to improve screening and support for patients with craniofacial conditions and their families, along with the development of interventions aimed at increasing resilience.