bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term right atrial catheters in patients with malignancies: An Indian experience
Authors: Alurkar Shirish S. , Dhabhar Boman N. , Pathak Anand B. , Gonsalves Iris , Iyer Rajaram S. , Kelkar Rohini , Pai Suresh K. , Deshpande Raman K. , Desai Prafulla B. , Advani Suresh H. 
Published: February 2007

AbstractNinety‐eight single lumen and two double lumen silicone right atrial Hickman/Broviac catheters inserted in 91 patients with various malignancies over a period of 36 months were prospectively studied. The average duration of use for all Hickman/Broviac catheters was 7,460 days with an average of 74.6 days. A total of 41 episodes of catheter‐related infections were documented in all patients (0.5 per 100 access days). Catheter related bacteremia was the most frequent type of infection (31 out of 41, 75%). Majority of the bacteremias could be controlled with routine antimicrobial therapy. Exit site infections were seen in 5 Hickman/Broviac catheters. Two catheters had to be removed because of catheter tunnel infections. Gram negative bacteremic infections were the most common, with Pseudomonas aeruginosa being the major pathogen. Silicone rubber Hickman/Broviac catheters proved to be convenient, reliable, and easily manageable devices in our experience. © 1992 Wiley‐Liss, Inc.
Mucinous biliary cystadenoma: A case report and review of the literature
Authors: Lind D. Scott , Adolph Vincent , Parker George A. 
Published: February 2007

AbstractMucinous biliary cystadenomas are rare neoplasms with protean manifestations. In most cases the mucinous material is retained within the cyst itself. We describe an asymptomatic case of a mucin secreting biliary cystadenoma in which the mucin presented as an amorphous intraluminal filling defect in the common hepatic duct on endoscopic retrograde cholan‐giopancreatography (ERCP). The neoplasm itself was confined to the posterior segment of the right hepatic lobe and was treated by formal right hepatic lobectomy. This case prompted a review of mucinous biliary cystadenomas. © 1992 Wiley‐Liss, Inc.
Gamma probe location of 111 indium‐labeled B72.3: An extension of immunoscintigraphy
Authors: Krag David N. , Haseman Michael K. , Ford Patrick , Smith Lloyd , Taylor Michael H. , Schneider Philip , Goodnight James E. 
Published: February 2007

AbstractEight colorectal and 5 ovarian cancer patients were evaluated with preoperative immunoscintigraphy and intraoperative gamma probe detection of 111indium‐labeled monoclonal antibody B72.3. Immunoscintigraphy detected the presence of tumor in every patient shown to have tumor at surgery. There was one false‐positive scan. A total of 21 pathologically verified lesions were identified at surgery in the 11 patients with tumor. Immunoscintigraphy localized 12 (57%) and intraoperative gamma probe detection located 17 (81%) of the lesions. Intraoperative probe detection located 6 of 8 lesions smaller than 1 cm and 3 lesions that were not identified on initial surgical exploration. The gamma probe offers information that is complementary to immunoscintigraphy in that (1) it aids the surgeon in locating intra‐ and extra‐abdominal lesions previously identified by immunoscintigraphy, (2) it locates lesions too small to be seen by immunoscintigraphy alone, (3) it locates lesions that otherwise might be missed at surgery, and (4) it provides objective evidence for adequacy of surgical resection of cancer in the abdominal cavity.
Clinicopathologic comparisons between estrogen receptor‐positive and ‐negative gastric cancers
Authors: Wu Chew‐Wun , Tsay Shyh‐Haw , Chang Tai‐Jay , Chang Hway‐May , Hsieh Mao‐Chih , Lui Wing‐Yiu , P'Eng Fang‐Ku , Chi Chin‐Wen 
Published: February 2007

AbstractWe report that a modified dextran‐coated charcoal (DCC) assay, including the addition of sodium molybdate and 5% DCC stripping of endogenous hormone, detected higher estrogen receptors (ERs) than those by the conventional assay. ERs in 21 gastric adenocarcinoma were determined by the modified DCC assay; 13 patients had ERs of 2.5 to 520.2 fmol/mg protein with a mean dissociation constant of 1.9 × 10×10 M. The remaining 8 patients had no detectable amount of the receptor. There were no differences between the ER‐positive and ER‐negative groups in clinico‐pathologic characteristics such as age, sex, tumor size, location, gross appearance, invasive depth, invasion of lymph vessel or vein of stomach wall, nodal involvement, peritoneal dissemination, liver metastasis, and curability. Histological analysis, using Japanese, Lauren's, or Ming's classifications, all revealed no differences between the ER‐positive and ‐negative groups. The survival rate was identical for the 2 study groups. These results suggest that the presence or absence of ERs in gastric adenocarcinoma does not correlate to either biologic or clinicopathologic characteristics of this tumor; the role of ERs in human gastric cancer remains to be elucidated. © 1992 Wiley‐Liss, Inc.
Transhiatal and transthoracic esophagectomy: A comparative study
Authors: Bolton John S. , Sardi Armando , Bowen John C. , Ellis James K. 
Published: February 2007

AbstractFrom January 1981 to December 1990, 55 consecutive patients underwent esophageal resection by either the transhiatal (THE, 26 patients) or transthoracic (TTE, 29 patients) approach. Patient age, tumor size, and tumor stage were similar in the two groups. THE patients had a significantly worse mean preoperative American Society of Anesthesiologists (ASA) risk class assigned by the anesthesiologist. Patients who underwent THE had a significantly lower operative mortality and rate of cardiopulmonary complications, significantly shorter intensive care unit and hospital length of stay, and a significantly better postoperative survival when operative deaths are included in the analysis. Operative deaths in the TTE group were concentrated among patients > 65 years of age (4 of 9 died), in an ASA risk class ⩾III (3 of 7 died) or with moderate or severe cardiac or pulmonary impairment preoperatively (4 of 6 died). © 1992 Wiley‐Liss, Inc.
Early drain removal following modified radical mastectomy: A randomized trial
Authors: Parikh Hemen K. , Badwe Rajendra A. , Ash Cathy M. , Hamed Hisham , Freitas Ruffo , Chaudary Murid A. , Fentiman Ian S. 
Published: February 2007

AbstractThe dilemma of increasing costs of medical care and shrinking health budgets has stimulated attempts to implement stricter control on expenditure without affecting the quality of care. This study shows that in patients with operable breast cancer, a policy of early discharge after a mastectomy did not have deleterious effects on wound healing and was well accepted by patients. In a randomized trial, drains were removed after either 3 or 6 days postmastectomy, and in both groups of patients there was no difference between the mean volumes of seromas aspirated or the number of aspirations and return visits to the hospital. This suggests that a policy of early discharge is safe, acceptable, economical, and may improve bed utilization. © 1992 Wiley‐Liss, Inc.
P‐glycoprotein expression in hepatocellular carcinoma
Authors: Isshiki Koichi , Nakao Akimasa , Ito Masafumi , Hamaguchi Michinari , Takagi Hiroshi 
Published: February 2007

AbstractIn hepatocellular carcinoma cell lines, the intensity of staining with the monoclonal antibody C‐219 to the multidrug‐resistant gene (mdr1) product P‐glycoprotein and the intensity of the band at a molecular weight of 170 KDa on Western blot were associated closely with resistance to Adriamycin but not with the resistance to cis‐dichlorodiamine platinum (CDDP). In clinical specimens, noncancerous liver tissue was regularly stained with this antibody on the biliary canalicular front of the hepatocyte cell membrane. In liver cancer tissue, however, regular staining as in the noncancerous regions of the liver was observed in only 16% of the patients, irregular staining was seen in only 24%, and no staining was seen at all in 60%. Staining of P‐glycoprotein with the C‐219 antibody is technically simple and is useful for studying the role of P‐glycoprotein in drug‐resistant hepatocellular carcinoma. © 1993 Wiley‐Liss, Inc.
The significance of ureteral obstruction in lnvasive transitional cell carcinoma of the urinary bladder
Authors: Leibovitch Ilan , Ben‐Chaim Jacob , Ramon Jacob , Madjar Igael , Engelberg Izchak S. , Goldwasser Benad 
Published: February 2007

AbstractUreteral obstruction is a frequent complication of transitional cell carcinoma (TCC), known as a poor prognostic sign and indicative of advanced disease. We investigated retrospectively the medical records of 122 consecutive patients who suffered from invasive TCC of the urinary bladder during a 6‐year period. Unilateral or bilateral ureteral obstruction was found in 66 patients (54.1%). High stage (T3‐T4) and grade (III‐IV) tumors were correlated with ureteral obstruction in 89.4% and 83.3% respectively compared to 67.9% and 66.1%, respectively, among patients with normal upper tracts (P < 0.001); 10.6% of the patients with ureteral obstruction had low stage disease, and all of them proved to have involvement of the ureteral orifices on the affected side. The 5‐year survival rate of patients with and without ureteral obstruction was 32.2% and 65.9%, respectively (P < 0.001). The presence of ureteral obstruction, particularly in the absence of intravesical involvement of the ureteral orifices, signified a high stage, muscle invasive, and often metastatic tumor in more than 90% of the patients. Ureteral obstruction was an accurate criterion for poor prognostic and was associated with significantly lower, overall and stage‐specific, survival rates, despite of radical surgery. We conclude that evidence of ureteral obstruction is an important staging standard and significant prognostic indicator in transitional cell carcinoma of the urinary bladder. © 1993 Wiley‐Liss, Inc.
Choroidal metastasis from primary adenocarcinoma of the esophagus
Authors: Parikh Hemen K. , Deshpande Raman K. , Swaroop Durga V. , Desai Prafulla B. 
Published: February 2007

AbstractPrimary adenocarcinoma of the esophagus is uncommon and the incidence in the middle third of the esophagus is rare, accounting for about 0.7%‐1.5% of cases. Metastasis of carcinoma to the eye is a rare occurrence. We report here a case of primary adenocarcinoma of the middle third of the esophagus with choroidal metastasis. © 1993 Wiley‐Liss, Inc.
Cancerous residue in breast‐conserving surgery
Authors: Morimoto Tadaoki , Okazaki Kuniyasu , Komaki Kansei , Sasa Mitsunori , Mori Toshiaki , Tsuzuki Hideo , Kamamura Yoshitaka , Miki Hitoshi , Monden Yasumasa 
Published: February 2007

AbstractLocal tumor extension was studied using a continuous series of multiple blocks of mastectomy specimens to assess malignancy remaining after breast‐conserving surgery for early‐stage breast cancer. In this study, 183 cases were chosen, consisting of 6 noninvasive ductal carcinoma cases and 177 invasive ductal carcinoma cases. The histopathology in 59 (32%) of the 183 cases corresponded to that showing extensions of more than 2.6 cm from the tumor margin. These wide extensions were also seen in 17% of breast cancers with a tumor size of less than 2 cm. The incidence of wide extension was higher in younger patients with cases of noninvasive ductal carcinoma. Extension to the nipple‐areola was seen in 14% of cases with a tumor size of less than 2 cm. Breast cancers with multicentric development accounted for 3% of those with a tumor size under 2 cm. These findings suggest that if lumpectomy is performed with a margin of 2 cm for tumors with a size of 2 cm or less, a cancerous residue would be found in the surgical margin of 15–20% of the cases. The actual incidence was 23% of cases after breast‐conserving treatment in our study. On the basis of the data, breast‐conserving treatment with only local resection of the primary lesion showed cancerous residue such as intraductal cancerous extension in about 20% of cases. Therefore, it was concluded that, as part of breast‐conserving therapy of early‐stage breast cancer, radiation therapy of the whole breast should be performed after surgery with clear margins to Control local recurrence. © 1993 Wiley‐Liss, Inc.
Heterogeneity in early and advanced gastric carcinomas by flow cytometric DNA analysis
Authors: Umehara Yasuhiko , Kimura Taizou , Yoshida Masayuki , Oba Noriyuki , Harada Yukio 
Published: February 2007

AbstractWe investigated 230 systematically sampled fresh specimens from 12 early and 26 advanced gastric cancer patients by DNA flow cytometry for heterogeneity in DNA content. Fifty‐eight percent of the 12 early gastric cancers were uniformly diploid and 42% were uniformly aneuploid. Fifty‐four percent of advanced cancers were uniformly diploid in superficial layers and 42% were uniformly diploid in deep layers, whereas 46% were uniformly aneuploid in superficial layers, and 50% were uniformly aneuploid and 8% were heterogeneously aneuploid and diploid in deep layers. Both diploid and aneuploid samples were obtained from 15% for advanced cancers, but ploidy heterogeneity did not occur in early cancers. Heterogeneity for DNA index (more than one aneuploid DNA index) occurred in 46% of whole thickness of advanced cancers, in 19% of superficial layers of advanced cancers, and in 8% of early cancers. We concluded that DNA ploidy determination using superficial layer specimens may be reliable in early gastric cancer but must be interpreted with care in advanced cancer. © 1993 Wiley‐Liss, Inc.
Postoperative outcome following thoracotomy in the pediatric oncology patient with diminished pulmonary function
Authors: Tobias Joseph D. , Bozeman Paula M. , MacKert Paul W. , Rao Bhaskar N. 
Published: February 2007

AbstractSurgical resection of pulmonary metastatic disease is often indicated in pediatric malignancies. Although several adult studies document increased postoperative morbidity in adults with diminished pulmonary function, there is little information in the pediatric population or in patients with restrictive lung disease. We reviewed the postoperative course following thoracotomy in patients with diminished pulmonary function (FVC, FEV1, or TLC less than 80% predicted). Thirty‐two thoracotomies were performed in 19 patients. The preoperative FVC (% predicted) was 68 ± 3.6 with a postoperative value of 60 ± 2.4 (P < 0.01). The preoperative FEV1 was 69 ± 4.2 with a postoperative value of 60 ± 3.8 (P < 0.01). Although there was a significant drop in pulmonary function tests (PFTs) following surgery, there was not a significantly greater loss when comparing patients with mild, moderate, and severe disease. When considering postoperative morbidity, there were 3 events (prolonged oxygen requirement, need for postoperative ventilation, or persistent air leak) following 20 surgeries in patients with mild preoperative respiratory dysfunction, 5 events (including one death) in the 7 patients with moderate dysfunction, and 3 events following 5 surgeries in patients with severe dysfunction. There was no correlation with a decrease in any specific PFT and the occurrence of postoperative morbidity. Our limited review suggests that aggressive surgical treatment of metastatic pulmonary disease is tolerated even in patients with severe decreases in pulmonary function. © 1993 Wiley‐Liss, Inc.
Distribution of adenosine deaminase binding protein in normal and malignant tissues of the gastrointestinal tract studied by monoclonal antibodies
Authors: Sakamoto Junichi , Watanabe Tadashi , Teramukai Satoshi , Akiyama Seiji , Morimoto Takesh , Takaci Hiroshi , Nakazato Hiroaki , Ueda Ryuzo , Takahashi Toshitada 
Published: February 2007

AbstractA mouse monoclonal antibody V‐715 was raised against fresh colon cancer tissues. Biochemical analysis elucidated that the antigen defined was adenosine deaminase binding protein (ADBP). In colon cancer cell lines, V‐715 was positive in 8 out of 16 differentiated cancers and in 2 out of 8 poorly differentiated cancers. In frozen sections, ADBP was expressed in 17 out of 33 differentiated colon cancers, but none of 4 poorly differentiated colon cancers. In normal colon, the expression was observed in epithelium. In gastric cancers, ADBP was expressed in 10 out of 15 differentiated cancers, but weakly or only heterogenously expressed in 2 out of 8 poorly differentiated cancers. In normal gastric mucosa, ADBP was mainly detected in the foveolar epithelium, but was weakly or not expressed in the deep gastric glands. Carcinoid tumors and malignant lymphoma of the stomach did not express ADBP. These results suggest that ADBP may act as a marker of enterocytic differentiation in normal and neoplastic gastrointestinal cells, and might be exploitable in clinical and pathological diagnosis of gastrointestinal cancers. © 1993 Wiley‐Liss, Inc.
Malignant pericardial effusion from squamous cell cancer of the cervix
Authors: Nelson Beth E. , Rose Peter G. 
Published: February 2007

AbstractAlthough rarely diagnosed in women with gynecologic cancers, pericardial metastasis and effusion are often considered preterminal events. As newer therapies result in prolongation of survival for women with advanced cervical cancer, uncommon metastatic sites may be seen with increasing frequency, and warrant increased attention by the gynecologist with oncologic expertise. Cases: Two women with squamous cell carcinoma and symptomatic pericardial effusion, one at initial presentation and the other as recurrent disease, are presented. Following pericardiocentesis, both patients received cisplatinum‐based chemotherapy. The patient with effusion at diagnosis survived four months, with recurrent effusion at death. The second patient had no return of cardiac symptoms, with twelve month survival. As demonstrated by the cumulative experience of the six reported cases of this entity, many women with pericardial involvement are candidates for aggressive radiation or chemotherapy. Duration of time from primary therapy prior to occurrence of effusion correlates with survival. © 1993 Wiley‐Liss, Inc.
Selective use of drains in thyroid surgery
Authors: Shaha Ashok R. , Jaffe Bernard M. 
Published: February 2007

AbstractIn the past, it was generally advised that every patient undergoing thyroid surgery have a drain placed because of the fear of post‐operative hematoma. In the past 9 year, we have performed 400 thyroidectomies. For the first 6 years, we drained the operative site in most of thyroid procedures. However, it was apparent from our experience that drains had very little effect on the prevention of post‐operative hematoma or of seroma. As a matter of fact, all four patients who required re‐exploration in our initial series had drains in place. As a result of this experience over the past 3 years, during which time we have performed 150 thyroidectomies, we have used drains selectively. The indications for draining for a large substernal goiter, and subtotal thyroidectomy for either large, multinodular goiter or for Graves' disease. Thus, among 150 recent thyroidectomies, we have drained only 35, and avoided drains in 115 patients. Though this is not a prospective study, we found no difference in the overall outcome whether drains were employed or not. Most patients who had no drains were ready for discharge within 24‐48 hours of surgery. Since it may be difficult to perform a randomized prospective trial examining the use of drains in thyroid surgery, we propose that drains should be utilized only selectively for thyroid surgery. © 1993 Wiley‐Liss, Inc.
Preoperative duplex venous imaging in the assessment of patients with venous access
Authors: Kraybill William G. , Allen Brent T. 
Published: February 2007

AbstractOccult or clinically apparent central venous thrombosis frequently complicates central venous catheter placemnt in patients requiring long‐term vascular access. Thirty‐three patients, aged 12‐83 years, underwent duplex scanning of the internal jugular, axillary, and brachial veins prior to placement of long‐term venous access catheters. Twenty‐seven patients underwent duplex scanning because of a prior history of either long‐term or short‐term central venous access. Of 12 patients with a history of long‐term central venous access, without complications, 42% (5/12) had an abnormal duplex scan demonstrating thrombosis. Duplex scans on 15 patents having complications associated with central venous access demonstrated thrombosis of one or more of the central veins, 46% (7/15). Five patients who underwent duplex scanning without a history of a previous central venous catheter or other indication were found to have normal normal central veins. In 13 patients found to have thrombosis or obstruction by duplex scan, the surgeon was directed to successful venous access in all cases. Normal findings were very helpful in confirming that the venous system was normal in selected patients. In approximately 40% of patients with a history of venous access, catheters were found to have evidence of thrombosis of one or more of the central veins. In 13 patients found to have thrombosis or obstruction by duplex scan, the surgeon was directed to a successful site for venous access in all cases. © 1993 Wiley‐Liss, Inc.
Significance of in vitro attachment of human colon cancers to extracellular matrix proteins in experimental and clinical liver metastases
Authors: Furukawa Toshiharu , Watanabe Masahiko , Kubota Tetsuro , Kase Suguru , Fujita Shin , Yamamoto Takaaki , Saikawa Yoshiro , Kuo Tsong‐Hong , Tanino Hirokazu , Kurihara Naoto , Kawano Yukio , Kawamoto Kiyoshi , Suto Akihiko , Teramoto Tatsuo , Ishibiki Kyuya , Kitajima Masaki 
Published: February 2007

AbstractThe attachment of 7 human colon cancer lines transplantable into nude mice, and primary tumors and liver metastases from 30 patients with colon cancer to 4 extracellular matrix proteins (EMPs)—Matrigel, laminin, fibronectin, and type IV collagen—was evaluated using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H (MTT) assay. Cancer cells from the 4 established tumor lines which produced experimental liver metastases in vivo showed significantly greater attachment to each EMP than those from the other 3 tumor lines which did not. Although there were no significant differences between attachment to EMPs of cancer cells from 15 clinical primary tumors with liver metastases and those without, attachment to each EMP of cells derived from liver metastases was significantly greater than that of the cells from the corresponding primary tumors in 8 cases for which liver metastases and primary tumors were examined simultaneously. Attachment to EMPs, which could be determined simply and rapidly using the MTT assay, is thus considered a significant factor in experimental and clinical liver metastases of human colon cancers. © 1993 Wiley‐Liss, Inc.