bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topological Strings on Non-commutative Resolutions
Authors: Katz Sheldon , Klemm Albrecht , Schimannek Thorsten , Sharpe Eric 
Published: February 2024

AbstractIn this paper we propose a definition of torsion refined Gopakumar–Vafa (GV) invariants for Calabi–Yau threefolds with terminal nodal singularities that do not admit Kähler crepant resolutions. Physically, the refinement takes into account the charge of five-dimensional BPS states under a discrete gauge symmetry in M-theory. We propose a mathematical definition of the invariants in terms of the geometry of all non-Kähler crepant resolutions taken together. The invariants are encoded in the A-model topological string partition functions associated to non-commutative (nc) resolutions of the Calabi–Yau. Our main example will be a singular degeneration of the generic Calabi–Yau double cover of $${\mathbb {P}}^3$$

P

3

and leads to an enumerative interpretation of the topological string partition function of a hybrid Landau–Ginzburg model. Our results generalize a recent physical proposal made in the context of torus fibered Calabi–Yau manifolds by one of the authors and clarify the associated enumerative geometry.
Dynamics of Gut Bacteria Across Different Zooplankton Genera in the Baltic Sea
Authors: Xu Tianshuo , Novotny Andreas , Zamora-Terol Sara , Hambäck Peter A. , Winder Monika 
Published: February 2024

AbstractIn aquatic ecosystems, zooplankton-associated bacteria potentially have a great impact on the structure of ecosystems and trophic networks by providing various metabolic pathways and altering the ecological niche of host species. To understand the composition and drivers of zooplankton gut microbiota, we investigated the associated microbial communities of four zooplankton genera from different seasons in the Baltic Sea using the 16S rRNA gene. Among the 143 ASVs (amplified sequence variants) observed belonging to heterotrophic bacteria, 28 ASVs were shared across all zooplankton hosts over the season, and these shared core ASVs represented more than 25% and up to 60% of relative abundance in zooplankton hosts but were present at low relative abundance in the filtered water. Zooplankton host identity had stronger effects on bacterial composition than seasonal variation, with the composition of gut bacterial communities showing host-specific clustering patterns. Although bacterial compositions and dominating core bacteria were different between zooplankton hosts, higher gut bacteria diversity and more bacteria contributing to the temporal variation were found in Temora and Pseudocalanus, compared to Acartia and Synchaeta. Diet diatom and filamentous cyanobacteria negatively correlated with gut bacteria diversity, but the difference in diet composition did not explain the dissimilarity of gut bacteria composition, suggesting a general effect of diet on the inner conditions in the zooplankton gut. Synchaeta maintained high stability of gut bacterial communities with unexpectedly low bacteria-bacteria interactions as compared to the copepods, indicating host-specific regulation traits. Our results suggest that the patterns of gut bacteria dynamics are host-specific and the variability of gut bacteria is not only related to host taxonomy but also related to host behavior and life history traits.
Resolving unknown nucleotides in the IPD-IMGT/HLA database by extended and full-length sequencing of HLA class I and II alleles
Authors: Voorter Christina E. M. , Groeneweg Mathijs , Olieslagers Timo I. , Fae Ingrid , Fischer Gottfried F. , Andreani Marco , Troiano Maria , Vidan-Jeras Blanka , Montanic Sendi , Hepkema Bouke G. , Bungener Laura B. , Tilanus Marcel G. J. , Wieten Lotte 
Published: February 2024

AbstractIn the past, identification of HLA alleles was limited to sequencing the region of the gene coding for the peptide binding groove, resulting in a lack of sequence information in the HLA database, challenging HLA allele assignment software programs. We investigated full-length sequences of 19 HLA class I and 7 HLA class II alleles, and we extended another 47 HLA class I alleles with sequences of 5′ and 3′ UTR regions that were all not yet available in the IPD-IMGT/HLA database. We resolved 8638 unknown nucleotides in the coding sequence of HLA class I and 2139 of HLA class II. Furthermore, with full-length sequencing of the 26 alleles, more than 90 kb of sequence information was added to the non-coding sequences, whereas extension of the 47 alleles resulted in the addition of 5.5 kb unknown nucleotides to the 5′ UTR and > 31.7 kb to the 3′ UTR region. With this information, some interesting features were observed, like possible recombination events and lineage evolutionary origins. The continuing increase in the availability of full-length sequences in the HLA database will enable the identification of the evolutionary origin and will help the community to improve the alignment and assignment accuracy of HLA alleles.
Altered biodistribution of [68Ga]Ga-DOTA-TOC during somatostatin analogue treatment
Authors: van de Weijer T. , Bemer F. , de Vos-Geelen J. , Hermans B. , Mitea C. , van der Pol J. A. J. , Lodewick T. , Wildberger J. E. , Mottaghy F. M. 
Published: February 2024

Abstract
Purpose
The need for an interval between the administration of long-acting Somatostatin Receptor Analogues (SSA) and the [68Ga]Ga-DOTA-TATE PET has been questioned based on recent literature in the new EANM guidelines. Here an earlier studies showed that SSA injection immediately before SSTR PET had minimal effect on normal organ and tumor uptake (1). However, data are scarce and there are (small) differences between [68Ga]Ga-DOTA-TATE and [68Ga]Ga-DOTA-TOC binding affinity, and it remains unknown whether these findings can be directly translated to scans with [68Ga]Ga-DOTA-TOC as well. The purpose of this study was to assess the effect of SSA use on the biodistribution in a subsequent [68Ga]Ga-DOTA-TOC PET/CT and compare this intra-individually across several cycles of SSA treatments.

Methods
Retrospectively, 35 patients with NENs were included. [68Ga]Ga-DOTA-TOC PET at staging and after the 1st and 2nd cycle of SSA were included. SUVmean and SUVmax of blood, visceral organs, primary tumor and two metastases were determined. Also, the interval between SSA therapy and the PET scan was registered.

Results
Treatment with SSA resulted in a significantly higher bloodpool activity and lower visceral tracer uptake. This effect was maintained after a 2nd cycle of SSA therapy. Furthermore, there was an inverse relationship between bloodpool tracer availability and visceral tracer binding and a positive correlation between bloodpool tracer availability and primary tumor tracer uptake. With an interval of up to 5 days, there was a significantly higher bloodpool activity than at longer intervals.

Conclusion
Absolute comparison of the SUV on [68Ga]Ga-DOTA-TOC PET should be done with caution as the altered biodistribution of the tracer after SSA treatment should be taken into account. We recommend not to perform a scan within the first 5 days after the injection of lanreotide.
Thermodynamic mixing properties of disordered alkali feldspar solid-solution from Na–K partitioning and low-temperature calorimetry
Authors: Heuser D. , Petrishcheva E. , Ingegneri F. , Lengauer C. L. , Dachs E. , Hauzenberger C. , Abart R. 
Published: February 2024

AbstractThe equilibrium partitioning of Na and K between alkali feldspar and NaCl–KCl salt melt was determined at 800 $$^\circ$$

∘

C, 850 $$^\circ$$

∘

C, 900 $$^\circ$$

∘

C, 950 $$^\circ$$

∘

C and 1000 $$^\circ$$

∘

C and close to ambient pressure. Four different natural gem-quality alkali feldspars with low degree of Al–Si ordering covering the range from orthoclase to high sanidine and with slightly different minor element concentrations were used as starting materials. The partitioning curves obtained for the four feldspars are indistinguishable indicating that Na–K partitioning independent of the differences of Al–Si ordering state and minor element concentrations existing amongst these feldspars. A sub-regular two parameter Margules type solution model was fitted to the partitioning data, and the excess Gibbs energy describing the thermodynamic non-ideality of the alkali feldspar solid-solution and the respective Margules parameters $$W_{\text {g}\text {K}}$$

W
gK

and $$W_{\text {g}\text {Na}}$$

W

g

including their temperature dependence expressed as $$W_g=W_h-TW_s$$

W
g

=

W
h

-
T

W
s

were determined: $$\begin{aligned} W_{\text {g}\text {K}}&= 19754 \pm 3140 J\cdot \,\,{\hbox {mol}}\,\,^{-1} - T \cdot 2.33 \pm 2.67 J\cdot \,\,{\hbox {mol}}\,\,^{-1}\cdot K^{-1} \\ W_{\text {g}\text {Na}}&= 14916 \pm 4272 J\cdot \,\,{\hbox {mol}}\,\,^{-1} - T \cdot 3.55 \pm 3.64 J\cdot {\hbox {mol}}\,\,^{-1}\cdot K^{-1} \\ \end{aligned}$$

W
gK

=
19754
±
3140
J
·

mol

-
1

-
T
·
2.33
±
2.67
J
·

mol

-
1

·

K

-
1

W

g

=
14916
±
4272
J
·

mol

-
1

-
T
·
3.55
±
3.64
J
·
mol

-
1

·

K

-
1

The corresponding solvus has a critical temperature slightly above 650 $$^\circ$$

∘

C and is well comparable with earlier direct experimental determinations of the low-sanidine-albite solvus curve. Comparison of the vibrational excess entropy determined from low-temperature heat capacity measurements with the total excess entropy derived from the temperature dependence of the excess Gibbs energy yields a negative configurational contribution to the excess entropy pointing towards short-range Na–K ordering on the alkali site.
Optimization of dry laser-induced graphene (LIG) electrodes for electrocardiography (ECG) signals monitoring
Authors: Gerardo Denice , Houeix Yann , Romero Francisco J. , Moraila Carmen L. , Blasco-Pascual Isabel , Pérez-Cadenas María , Morales Diego P. , Rodriguez Noel , Salinas-Castillo Alfonso 
Published: February 2024

AbstractThis work presents the optimization of the fabrication procedure for laser-induced graphene (LIG) electrodes intended for biopotentials acquisition. The results presented in this study demonstrate a significant improvement with respect to the performance obtained for other LIG-based electrodes previously reported in the literature. In particular, we propose the use of a galvanometric laser instead of a CNC laser to improve the engraving resolution and the LIG synthesis process, thus enhancing the surface area of the interface skin–electrode. For that, we have studied the resistance of the resulting LIG patterns as a function of the laser parameters (engraving power and scan speed) seeking their optimization. After tunning the laser fabrication process, we have fabricated and characterized electrocardiogram (ECG) electrodes with different surface areas using a commercial silver-based electrode as a reference. Thus, circular electrodes with a diameter of 15 mm, 10 mm and 6.5 mm were used to acquire the ECG on different volunteers using a commercial equipment. The signals acquired were processed afterwards with cutting edge processing techniques to perform a statistical analysis in terms of sensitivity, specificity, positive prediction and accuracy for the detection of QRS complexes. The results demonstrate that the proposed electrodes improve the signal acquisition with respect to the previously reported LIG-based electrodes in terms of noise and do present comparable or even better results than commercial electrodes (even with a smaller surface area) with the additional advantage of not requiring the use of an electrolyte gel.
The intersection of sleep and synaptic translation in synaptic plasticity deficits in neurodevelopmental disorders
Authors: Coulson Rochelle L. , Mourrain Philippe , Wang Gordon X. 
Published: February 2024

AbstractIndividuals with neurodevelopmental disorders experience persistent sleep deficits, and there is increasing evidence that sleep dysregulation is an underlying cause, rather than merely an effect, of the synaptic and behavioral defects observed in these disorders. At the molecular level, dysregulation of the synaptic proteome is a common feature of neurodevelopmental disorders, though the mechanism connecting these molecular and behavioral phenotypes is an ongoing area of investigation. A role for eIF2α in shifting the local proteome in response to changes in the conditions at the synapse has emerged. Here, we discuss recent progress in characterizing the intersection of local synaptic translation and sleep and propose a reciprocal mechanism of dysregulation in the development of synaptic plasticity defects in neurodevelopmental disorders.
Is high salt intake inducing obesity via production of cortisol? A novel working hypothesis and pilot study
Authors: Nowell Anthony , Torres Susan J. , Hall Sarah J. , Keske Michelle A. , Torpy David J. , Parker Lewan , Betik Andrew C. , Turner Anne I. 
Published: February 2024

Abstract
Purpose
Evidence is growing that high salt intake is an independent risk factor for obesity, but the mechanisms are unknown. Our novel working hypothesis is that high salt intake drives cortisol production, which in turn, drives obesity. The current study aimed to demonstrate an acute cortisol response following a single high salt meal.

Methods
Eight participants (age 30.5 ± 9.8 years [mean ± SD], 50% female), consumed high salt (3.82 g; 1529 mg sodium) and low salt (0.02 g; 9 mg sodium) meals in a randomized cross-over design.

Results
Urinary and salivary cortisol and plasma adrenocorticotropic hormone (ACTH) demonstrated order effects. When high salt was given second, there was a peak above baseline for urinary cortisol (26.3%), salivary cortisol (9.4%) and plasma ACTH (4.1%) followed by a significant decline in each hormone (treatment*time, F[9, 18] = 2.641, p = 0.038, partial η2 = 0.569; treatment*time, F[12, 24] = 2.668, p = 0.020, partial η2 = 0.572; treatment*time, F[12, 24] = 2.580, p = 0.023, partial η2 = 0.563, respectively), but not when high salt was given first (p > 0.05 for all).

Conclusion
These intriguing findings provide partial support for our hypothesis and support a need for further research to elucidate the role of high salt intake in cortisol production and, in turn, in the aetiology of obesity.

Trial registration number
ACTRN12623000490673; date of registration 12/05/2023; retrospectively registered.
Impact of obesity in the identification of the sentinel lymph node in endometrial cancer: a retrospective, monocentric study and literature review
Authors: Insalaco Giulio , Incognito Giosuè Giordano , Genovese Fortunato , Gulino Ferdinando Antonio , Rivoli Luca , Ciancio Fabio , Valenti Gaetano , Incognito Dalila , Carbone Ludovico , Palumbo Marco 
Published: February 2024

Abstract
Purpose
To evaluate the sentinel lymph node (SLN) protocol for staging endometrial carcinomas, assessing its impact on surgical management, and determining indications for adjuvant therapies. The study also examines factors that may influence SNL mapping, particularly focusing on the failure of the technique due to obesity.

Methods
A retrospective analysis was conducted on the medical records of patients with a histological diagnosis of endometrial carcinoma, who underwent surgical staging with SLN biopsy. The lymph node status was compared between non-obese (group 1) and obese (group 2) patients.

Results
71 women were included in the study, of which 33 were non-obese (46.5%) and 38 were obese (53.5%). The failure detection rate was higher in obese patients (14, 36.8%) compared to non-obese patients (5, 15.2%) (p = 0.039). The risk of mapping failure increased by 1.6 times for every 5-unit increase in body mass index (BMI) (OR 1.672, 95% CI 1.024–2.730, p = 0.040). BMI was confirmed as an independent risk factor for mapping failure in both univariate (OR 3.267, 95% CI 1.027–10.395, p = 0.045) and multivariate analyses (OR 5.779, 95% CI 1.320–25.297, p = 0.020).

Conclusion
SLN detection in obese patients requires great care, as obesity may alter the sensitivity of the technique.
Don’t delay, but don’t despair: symptom duration, comorbidity and outcome after closure of spinal cerebrospinal fluid leaks
Authors: Volz Florian , El Rahal Amir , Fung Christian , Shah Mukesch , Lützen Niklas , Urbach Horst , Beck Jürgen , Wolf Katharina 
Published: February 2024

Abstract
Objective
Microsurgical sealing of spinal cerebrospinal fluid (CSF) leaks is a viable treatment option in spontaneous intracranial hypotension (SIH). Several factors may influence the outcome, with symptom duration probably the most modifiable variable.

Methods
Patients with closure of spinal CSF leaks between September 2020 and March 2023 and a follow-up period of 6 months were included in this retrospective single-center study. Pre- and postoperative scores for impact of headaches (Headache Impact Test, HIT-6) and quality of life (QoL, EQ-5D-5L) were systematically collected. Multiple regression modelling and subgroup analyses for different symptom durations and comorbidities were performed for these outcomes.

Results
One hundred patients (61% female, median age 43.5 years) were included. Six months postoperatively, there was significant improvement in headache impact (HIT-6: 66 (IQR 62–69) to 52 (IQR 40–61, p < 0.001) and QoL (EQ-5D-5L VAS: 40 (IQR 30–60) to 79 (IQR 60–90); EQ-5D-5L Index: 0.67 (IQR 0.35–0.8) to 0.91 (IQR 0.8–0.94, p < 0.001, respectively). Subgroup analysis for a symptom duration above (74%) and below 90 days (26%) and comorbidity, as well as multiple regression analysis, revealed a trend in favor of early treatment and lower comorbidity. However, even after a prolonged symptom duration, improvements were significant.

Conclusion
As patients with shorter symptom duration show a trend for a better outcome, our results promote a timely diagnosis and treatment in SIH patients. However, a significant postoperative improvement can still be expected even after a prolonged symptom duration.
Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice
Authors: Ala-Nisula Tuulia , Halmetoja Riikka , Leinonen Henri , Kurkela Margareta , Lipponen Henna-Riikka , Sakko Samuli , Karpale Mikko , Salo Antti M. , Sissala Niina , Röning Tapio , Raza Ghulam S. , Mäkelä Kari A. , Thevenot Jérôme , Herzig Karl-Heinz , Serpi Raisa , Myllyharju Johanna , Tanila Heikki , Koivunen Peppi , Dimova Elitsa Y. 
Published: February 2024

AbstractTransmembrane prolyl 4-hydroxylase (P4H-TM) is an enigmatic enzyme whose cellular function and primary substrate remain to be identified. Its loss-of-function mutations cause a severe neurological HIDEA syndrome with hypotonia, intellectual disability, dysautonomia and hypoventilation. Previously, P4H-TM deficiency in mice was associated with reduced atherogenesis and lower serum triglyceride levels. Here, we characterized the glucose and lipid metabolism of P4h-tm−/− mice in physiological and tissue analyses. P4h-tm−/− mice showed variations in 24-h oscillations of energy expenditure, VO2 and VCO2 and locomotor activity compared to wild-type (WT) mice. Their rearing activity was reduced, and they showed significant muscle weakness and compromised coordination. Sedated P4h-tm−/− mice had better glucose tolerance, lower fasting insulin levels, higher fasting lactate levels and lower fasting free fatty acid levels compared to WT. These alterations were not present in conscious P4h-tm−/− mice. Fasted P4h-tm−/− mice presented with faster hepatic glycogenolysis. The respiratory rate of conscious P4h-tm−/− mice was significantly lower compared to the WT, the decrease being further exacerbated by sedation and associated with acidosis and a reduced ventilatory response to both hypoxia and hypercapnia. P4H-TM deficiency in mice is associated with alterations in whole-body energy metabolism, day-night rhythm of activity, glucose homeostasis and neuromuscular and respiratory functions. Although the underlying mechanism(s) are not yet fully understood, the phenotype appears to have neurological origins, controlled by brain and central nervous system circuits. The phenotype of P4h-tm−/− mice recapitulates some of the symptoms of HIDEA patients, making this mouse model a valuable tool to study and develop tailored therapies.
Atopic dermatitis in early life and pain at 10 years of age: An exploratory study
Authors: Gorito Vanessa , Brandão Maria , Azevedo Inês , Moreira André , Lucas Raquel 
Published: February 2024

AbstractPain is a distinctive burden in atopic dermatitis and recognized as an important and highly prevalent symptom. It is unknown if the presence of atopic disease may sensitize children to adverse pain profiles in the long term. We aimed to assess the impact of early-life atopic dermatitis-like symptoms on pain at 10 years of age. We used data from 1302 and 874 participants of the Generation XXI birth cohort evaluated at 6 and 15 months, respectively, and 10 years. Atopy-like symptoms since birth, including atopic dermatitis, were collected at ages 6 and 15 months by interviewing parents. Pain history in the last 3 months at age 10 was collected from parents and children using structured questionnaires. We computed relative risks (RR) and respective 95% confidence intervals of pain features at age 10 according to each atopic-like symptom at 6 and 15 months. Children whose parents reported atopic dermatitis-like symptoms at 6 months and at 15 months had higher risk of reporting any pain (RR 1.75 [1.15–2.66]) and multisite pain, respectively (RR 1.67 [1.18–2.37]) at 10 years of age. Conclusion: Atopic dermatitis symptoms in early life were associated with a higher risk of pain at age 10, suggesting that potential for sensitization during the first decade of life and highlighting the importance of improving the health care of children with atopic dermatitis is worth investigating.

What is Known:• Atopic disorders have been associated with many non-atopic comorbidities, including chronic pain.• Pain and atopic dermatitis share common inflammatory pathways. Inflammation, injury to the skin from scratching, fissures, and intolerance to irritants related to atopic dermatitis can cause pain.

What is New:• Atopic dermatitis in early life is linked to an increased likelihood of experiencing pain at the age of 10, which suggests that exploring the potential for sensitization is a worthwhile area of investigation.• Our proof-of-concept study highlights the potential benefit of studying management targets and improving itching and relieving skin pain as quickly as possible, avoiding potential long-term consequences of the sensitization process.
Helicobacter pylori upregulates circPGD and promotes development of gastric cancer
Authors: Zhao Wenjun , Yao Zhendong , Cao Jia , Liu Yun , Zhu Linqi , Mao Boneng , Cui Feilun , Shao Shihe 
Published: February 2024

Abstract
Purpose
Helicobacter pylori (H. pylori) has unique biochemical traits and pathogenic mechanisms, which make it a substantial cause of gastrointestinal cancers. Circular RNAs (circRNAs) have concurrently been identified as an important participating factor in the pathophysiology of several different cancers. However, the underlying processes and putative interactions between H. pylori and circRNAs have received very little attention. To address this issue, we explored the interaction between H. pylori and circRNAs to investigate how they might jointly contribute to the occurrence and development of gastric cancer.

Methods
Changes in circPGD expression in H. pylori were detected using qRT-PCR. Cell proliferation and migration changes were assayed by colony formation, the CCK-8 assay and the transwell assay. Apoptosis was measured by flow cytometry. Western blot was conducted to detect changes in cell migration, apoptosis, proliferation and inflammation-associated proteins. QRT-PCR was used to measure changes in circPGD and inflammation-associated factors.

Results
We found that H. pylori induced increased circPGD expression in infected human cells and facilitated gastric cancer progression in three ways by promoting cell proliferation and migration, enhancing the inflammatory response, and inhibiting apoptosis.

Conclusions
CircPGD appears to play a role in H. pylori-related gastric cancer and may thus be a viable, novel target for therapeutic intervention.