bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dairy intake in association with asthma symptoms among a large sample of children and adolescents: a cross-sectional study
Authors: Jamalvandi Mona , Sasanfar Bahareh , Nafei Zahra , Behniafard Nasrin , Jafari Marjan , Salehi-Abargouei Amin 
Published: March 2024

Background and objectiveDairy products may be associated with an increased risk of asthma, although there is little scientific evidence to support this association. The goal of this study was to explore the association between dairy consumption and asthma symptoms.Materials and methodsThis cross-sectional study was conducted on children and adolescents aged 6–8 and 13–14 years living in central Iran. Dietary food consumption was assessed using a multiple-choice questionnaire. Logistic regression was used to obtain odds ratios for the association between milk, other dairy products, and total dairy consumption with the risk of asthma symptoms.ResultsIn total, 7,667 participants (3,414 boys and 4,253 girls) were included in the current study. Milk intake and total dairy consumption were not associated with the likelihood of wheezing, asthma confirmed by a doctor, current asthma, and asthma medication use. In addition, there was no association between other dairy product intake and the odds of wheezing in the past 12 months in the crude model. However, after adjusting for several confounders, those in the top category had lower odds of wheezing in the past 12 months than those in the bottom category (OR: 0.58; 95% CI: 0.40–0.85).ConclusionThe consumption of dairy products other than milk, including cheese and yogurt, might reduce the likelihood of wheezing in children and adolescents.
Changes in the consumption of isoflavones, omega-6, and omega-3 fatty acids in women with metastatic breast cancer adopting a whole-food, plant-based diet: post-hoc analysis of nutrient intake data from an 8-week randomized controlled trial
Authors: Lee Jean , Campbell Erin K. , Culakova Eva , Blanchard Lisa M. , Wixom Nellie , Peppone Luke J. , Campbell Thomas M. 
Published: March 2024

BackgroundDiets rich in minimally processed plant-based foods are recommended to breast cancer patients, and some may have an interest in whole-food, plant-based (WFPB) diets that avoid animal-based foods, added fats, and refined sugars. Within WFPB diets, the intakes of isoflavones, omega-6 polyunsaturated fatty acids (n-6 PUFAs), and omega-3 polyunsaturated FAs (n-3 PUFAs), which have been discussed in reference to breast cancer outcomes, have not been well characterized.MethodsWomen with stage IV breast cancer on stable therapy were randomized 2:1 into (1) a WFPB intervention (N = 21) or (2) usual care (N = 11) for 8 weeks. Three meals per day were provided. Outcomes presented here include dietary intake of isoflavones, n-3 and n-6- PUFAs, which were assessed using three-day food records at baseline and 8 weeks. Baseline and 8-week mean intake within groups were compared using the Wilcoxon signed-rank test and between control and intervention groups by a two-sample t-test.ResultsThe WFPB intervention participants increased their daily consumption of total isoflavones from a mean of 0.8 mg/day to 14.5 mg/day (p &lt; 0.0001) and decreased the n-6:n-3 ratio of their diet from a mean of 9.3 to 3.7 (p &lt; 0.0001). Within the WFPB group, linoleic acid (n-6 PUFA) consumption decreased by a mean of 3.8 g (p = 0.0095), from 12.8 g/day to 9.0 g/day; total n-3 PUFA consumption increased by a mean of 1.1 g (p = 0.0005), from 1.6 g/day to 2.7 g/day.ConclusionTransitioning to a WFPB diet resulted in significantly increased isoflavone intake and decreased n-6:n-3 ratio in women with breast cancer.
Efficient long-wave infrared ZGP optical parametric oscillator pumped by a diode-pumped AO Q-switched Ho:YAG laser
Authors: Hou Zuoxun , Yang Song , Zheng Guoxian 
Published: March 2024

We describe an efficient long-wave infrared optical parametric oscillator based on ZnGeP2 crystal pumped by a diode-pumped AO Q-switched Ho:YAG laser in this paper. The wavelength of the laser pulse generated by Ho:YAG laser is 2.09-μm, and the maximum output average power is 25.3 W at repetition rate of 10 kHz. When pumped by such Ho:YAG laser, the maximum average output power of 0.66 W at 9.8 μm is achieved, corresponding to slope efficiency of 5.0% and optical efficiency of 2.6%. Furthermore, the beam quality factor of the long-wave infrared beam is measured to be approximately 1.3. To the authors’ best knowledge, this is the best performance reported for a long-wave infrared ZGP-OPO pumped by a diode-pumped AO Q-switched Ho:YAG laser.
Motivational variations in fitness: a population study of exercise modalities, gender and relationship status
Authors: Vuckovic Vojko , Duric Sasa 
Published: March 2024

IntroductionMotivation plays a crucial role in determining whether or not a person adheres to an exercise program. The present study aimed to determine the motivational differences between people exercising in fitness alone, in groups/aerobics and with a personal trainer by gender and relationship status.MethodsThe Exercise Motivations Inventory-2 (EMI-2) questionnaire was completed by 830 users of 20 largest fitness centers in Slovenia.ResultsThe Kruskal-Wallis test followed by a Dunn post-hoc test revealed that health-related motives such as ill-health avoidance were most frequently associated with exercising with a personal trainer compared to other exercise modalities, especially among females (p = 0.032, M = 4.88) and people in a relationship (p = 0.020, M = 5.18). On the other hand, intrinsic motivations such as enjoyment and stress management were mostly associated with exercising alone (p = 0.002, M = 4.98 and p = 0.021, M = 4.68, respectively). These results were also transferred to females and to some extent to people in a relationship (for enjoyment only). It is expected that intrinsic motivation is related to sustained exercise behavior.DiscussionFuture studies could implement a longitudinal design to test this statement and examine the proposed relationships over a longer period to better understand whether there may be causal relationships between motivation and different exercise modalities depending on different characteristics of participants.
Protocol for the “magnitude of cigarette substitution after initiation of e-cigarettes and its impact on biomarkers of exposure and potential harm in dual users” (MAGNIFICAT) study
Authors: Polosa Riccardo , Pluym Nikola , Scherer Max , Belsey Jonathan , Russell Christopher , Caponnetto Pasquale , Weglarz Jakub , Campagna Davide 
Published: March 2024

IntroductionMany smokers who use e-cigarettes (ECs) to quit continue smoking alongside vaping. The impact on health among individuals who simultaneously smoke conventional cigarettes (CCs) and use ECs remains unclear. The varying patterns of dual use present differing levels of overall toxin exposure and relative risks concerning smoking-related diseases. Understanding these complexities is vital to assessing the implications for human health.ObjectiveHerein we describe a protocol designed to analyze the impact of different level of substituting CCs with ECs on exposure to toxicants. We’ll use biomarkers to measure this exposure and assess harm reduction in dual users through clinical endpoints, harm-related biomarkers, and behavioral correlations. We expect to observe progressive changes with varying patterns of dual use.Methods and analysesFor this purpose, we planned to recruit a group of 250 smokers who will be asked to reduce their CC consumption by adopting ECs (intervention group). A separate group of 50 smokers will continue to smoke CC (reference group). Study groups will be followed up for 6 months during which biospecimens will be collected for biomarker analyses, and clinical endpoints will be assessed. The trial is structured to characterize subjects’ usage patterns over time using robust biomarkers of exposure and a standardized mobile phone application to facilitate the precise categorization of dual users along the risk continuum based on their usage behaviors. Subject recruitment will start in February 2024 and enrolment is expected to be completed by August 2024. Results will be reported early in 2025. Study findings may provide valuable insights into health benefits or risks associated with varying patterns of dual use.Ethics and disseminationThe study protocol and informed consent forms will be approved by the local Ethical Review Boards. Study results will be disseminated through articles published in reputable, peer-reviewed, open access, scientific journals, presentations at conferences, and the University website.
Menopause and facial skin microbiomes: a pilot study revealing novel insights into their relationship
Authors: Pagac Martin Patrick , Stalder Martin , Campiche Remo 
Published: March 2024

Introduction: The human skin microbial composition is affected by age. Previous studies reported skin microbiome diversity shifts between elderly and significantly younger subjects. Some studies implied that menopausal status, which is inherently linked to age, could be associated with changes in skin microbial compositions. Nevertheless, the influence of menopausal status on skin microbiome profiles while minimizing the impact of aging-associated changes in skin parameters still needs further clarification.Methods: We performed an observational study on healthy Caucasian female volunteers, which were grouped according to their pre- or postmenopausal status. Bacterial community structures on facial skin were analyzed using 16S rRNA gene sequencing. Cutometer® measurements were performed to evaluate aging-associated changes in facial skin biophysical properties.Results: The relative abundance of the lipophilic Cutibacterium genus was decreased, and bacterial diversity was increased in skin samples of postmenopausal volunteers. The mean age difference between examined groups in this study was 12.4 years only. Accordingly, Cutometer® measurements revealed no differences in aging-associated skin biophysical parameters between pre- and postmenopausal groups. Consequently, no correlation was detected between Shannon diversity and measured age-dependent biomechanical properties of facial skin.Discussion: These findings are in line with previous studies, which investigated the wide-ranging impact of chronological aging on skin microbial communities. However, this work reports for the first time a direct association between menopausal status and facial microbiomes on skin of similarly aged study participants, and hence uncouples aging-associated skin biophysical parameters, such as viscoelastic properties, from the equation. These findings open avenues for the development of microbiome-targeting strategies for treatment of menopause-associated skin disorders.
How do the existing homecare services correspond with the preferred service ecosystem for senior citizens living at home? A qualitative interview study with multiple stakeholders
Authors: Kattouw Christophe Eward , Aase Karina , Viksveen Petter 
Published: March 2024

IntroductionOften, homecare services are task-focused rather than person-based and fragmented instead of integrated. Consequently, several stakeholders have requested a transformation of the service ecosystem for senior citizens living at home. This transformation may be facilitated by an idealized design approach. However, few studies have applied such an approach. Moreover, previous research did not assess the ways in which the existing homecare services correspond with the preferred service ecosystem for senior citizens living at home. Therefore, the purpose of this study is to gain an understanding of how the existing homecare services correspond with the preferred service ecosystem for senior citizens living at home, according to different stakeholders.MethodsFour stakeholder groups (n = 57) from a Norwegian municipality participated in an interview study (2019–2020): senior citizens, carers, healthcare professionals and managers. A directed qualitative content analysis was applied, guided by a four-category framework for the preferred service ecosystem.ResultsAll stakeholder groups highlighted several limitations that hindered continuity of the services. There was also agreement on deficiencies in professionals’ competence, yet professionals themselves did not focus on this as a significant aspect. Managers emphasised the importance of professionals’ reablement competence, which was also considered to be deficient in the current homecare services. Contrary to the other stakeholder groups, most senior citizens seemed satisfied with the practical and social support they received. Together with carers, they also explained why they thought some professionals lack compassion. Their dependency on professionals may limit them in sharing honestly their opinions and preferences during care provision. Involvement of senior citizens in improvement of the current services was limited. Insufficient time and resources, as well as a complex organisation impacted the existing homecare services, and therefore served as barriers to the preferred service ecosystem.DiscussionIn this study there were different degrees of correspondence between the existing homecare services and the preferred service ecosystem according to four stakeholder groups. To develop the preferred service ecosystem, aspects such as predictability, adaptivity, and relationships are key, as well as continuous involvement of senior citizens and other stakeholders. The four-category framework applied in this study served as a tool to assess the existing homecare services.
Intradermal methylene blue analgesic application in posthemorrhoidectomy pain management: a randomized controlled trial
Authors: Azhough Ramin , Jalali Pooya , Dashti Mohammad Reza , Taher Sahar , Aghajani Ali 
Published: March 2024

IntroductionUnbearable post-hemorrhoidectomy pain is a well-documented challenge, significantly impacting patient well-being and satisfaction after surgery, often influencing patients to decline in undergoing this procedure. It is widely recognized that methylene blue has an effect of reducing inflammation and pain by reduces the production of nitric oxide and inhibiting the action potentials production in nerves. This study aims to explore the potential benefits of postoperative regional administration of methylene blue in providing extended relief from post-hemorrhoidectomy pain.MethodsThis study included 97 patients aged 18–75 undergoing hemorrhoidectomy for stage III or IV hemorrhoids. A double-blind, randomized controlled trial compared postoperative intradermal injections of 1% methylene blue to 0.5% Marcaine as the control group. Two-week follow-up assessed pain. Statistical analysis, adherence to ethical standards, and registration were conducted.ResultNo significant differences were found in baseline demographics, surgical parameters, or complications between the Methylene Blue and control groups. Intervention group remained lower in mean pain score until the 12th day. Methylene blue group reported significantly lower postoperative pain scores from days 1 to 7, with no significant differences afterward.ConclusionThis ongoing randomized controlled trial reveals the potential analgesic benefits of intradermal injection 1% methylene blue. It demonstrates comparable efficacy in reducing post-hemorrhoidectomy pain, with negligible side effects and complications.
Comparison of the efficacy of Aeromonas veronii ΔhisJ vaccine in Carassius auratus via different immunization routes
Authors: Wu Tonglei , Ma Ruitao , Pan Xiaoyi , Wang Fengjie , Zhang Zhiqiang , Shi Qiumei , Shan Xiaofeng , Gao Guisheng 
Published: March 2024

IntrodctionAeromonas veronii is a significant pathogen to various aquatic life. Infections in fish can lead to high mortality rates, causing substantial economic losses in aquaculture. Vaccination is proposed as a substitute for antibiotics in aquaculture to decrease disease-related mortality and morbidity. Our study previously constructed a hisJ-deleted strain of A. veronii, which provided protective effect to Loach.MethodsTo further assess the vaccine’s applicability, this study evaluated its genetic stability and safety, and the immune protective effects in Carassius auratus through four distinct administration routes: intraperitoneal injection, intramuscular injection, oral administration, and immersion, to determine the efficacy of these administration routes.ResultsThe results showed that the vaccine remained genetically stable after 45 generations. Immunization via these administration routes was safe for Carassius auratus, with intraperitoneal and intramuscular injections causing stronger adverse reactions. Immersion immunization resulted in mild adverse reactions, and no significant adverse reactions were observed following oral immunization. Immunizing Carassius auratus at safe concentrations via these routes enhanced the phagocytic activity in serum, increased the levels of non-specific immune-related enzymes (ACP, AKP, C3, C4, LZM, SOD, and IgM), and improved specific serum antibody levels. It also elevated levels of cytokines related to inflammatory responses (IL-1β, IL-10, TNF-α, TGF-β) in organ tissues (liver, spleen, kidney, mid-post intestine, and gills). The survival rates of Carassius auratus were measured after challenging with the virulent strain A. veronii TH0426, resulting in the relative survival rates of 64% for Intraperitoneal vaccine group, 56% for Intramuscular vaccine group, 52% for oral vaccine group, and 48% for immersion vaccine group. Analysis of bacterial load in the liver, spleen, and kidney post-challenge showed a decreasing trend in the control group, indicating that the vaccine strain ΔhisJ could gradually restrict the rapid proliferation of bacteria in these tissues, thereby providing a certain level of immune protection against A. veronii.DiscussionIn brief, the vaccine strain ΔhisJ can serve as a safe live attenuated vaccine for Carassius auratus, and this study lays the foundation for the development of live attenuated vaccines against Aeromonas veronii.
Fungemia by Wickerhamomyces anomalus—A Narrative Review
Authors: Ioannou Petros , Baliou Stella , Kofteridis Diamantis P. 
Published: March 2024

Wickerhamomyces anomalus has been previously classified as Hansenula anomala, Pichia anomala, and Candida pelliculosa and was recently reclassified in the genus Wickerhamomyces after phylogenetic analysis of its genetic sequence. An increasing number of reports of human infections by W. anomalus have emerged, suggesting that this microorganism is an emerging pathogen. The present review aimed to provide data on the epidemiology, antifungal resistance, clinical characteristics, treatment, and outcomes of fungemia by W. anomalus by extracting all the available information from published original reports in the literature. PubMed/Medline, Cochrane Library, and Scopus databases were searched for eligible articles reporting data on patients with this disease. In total, 36 studies involving 170 patients were included. The age of patients with fungemia by W. anomalus ranged from 0 to 89 years; the mean age was 22.8 years, the median age was 2.2 years, with more than 37 patients being less than one month old, and 54% (88 out of 163 patients) were male. Regarding patients’ history, 70.4% had a central venous catheter use (CVC), 28.7% were on total parenteral nutrition (TPN), 97% of neonates were hospitalized in the neonatal ICU (NICU), and 39.4% of the rest of the patients were hospitalized in the intensive care unit (ICU). Previous antimicrobial use was noted in 65.9% of patients. The most common identification method was the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in 34.1%, VITEK and VITEK 2 in 20.6%, and ID32 C in 15.3%. W. anomalus had minimal antifungal resistance to fluconazole, echinocandins, and amphotericin B, the most commonly used antifungals for treatment. Fever and sepsis were the most common clinical presentation noted in 95.8% and 86%, respectively. Overall mortality was 20% and was slightly higher in patients older than one year. Due to the rarity of this disease, future multicenter studies should be performed to adequately characterize patients’ characteristics, treatment, and outcomes, which will increase our understanding and allow drawing safer conclusions regarding optimal management.
L’évolution du filtrage des investissements étrangers dans le cadre de la pandémie de Covid-19
Authors: Castellarin Emanuel 
Published: March 2024

La pandémie de Covid-19 a suscité la crainte d’investissements étrangers dans des actifs importants pour des raisons sanitaires, économiques ou autres, qui pourraient faire l’objet de comportements anticoncurrentiels ou d’utilisations dangereuses. Cette situation a
accéléré la tendance générale au renforcement des mécanismes de filtrage. Le mécanisme français de filtrage a été renforcé, sans modification structurelle du cadre préexistant, dans lequel le critère de la sécurité ou de l’ordre public assure en principe le respect du droit international. Le critère de la sécurité ou de l’ordre public est structurant aussi pour le récent cadre de filtrage au niveau de l’Union européenne, pour lequel la pandémie est le premier temps fort. Cependant, la crise de la Covid-19 entraîne aussi une possible évolution du filtrage : le lien avec la sécurité ou l’ordre public semble apprécié de manière de plus en plus souple et, dans le «monde d’après » , pourrait être complété par des critères purement économiques.
ESKİ MEZOPOTAMYA'DA İKİ KÜLT SANATÇISI: ASSİNNU ve KURGARRU
Authors: SÜNBÜL Nazan 
Published: March 2024

Eski Mezopotamya inanç sistemi, kült uygulamaları ve müzik kültüründe varlığı tespit edilen Assinnu ve Kurgarru adlı görevli/müzisyenler, onlara dair bilgi veren belgelerin çoğunda birlikte anılmaktadır. Eski Mezopotamya uygarlıklarına ait yazılı belgelerden Sumer Dönemi’nden Helenistik Dönem’e kadar geniş bir zaman aralığında izleri takip edilebilen bu görevlilerin,Tanrıça Inanna (Ištar) kültü kapsamında gerçekleştirilen sözlü veya enstrümantal müzikal icra, dans, külte ilişkin oyun ve canlandırmalar gibi çeşitli etkinliklerde yer aldıkları anlaşılmaktadır.
Eski Mezopotamya uygarlıklarına ait edebi belgeler,sözlük listeleri, mensubu oldukları tanrıçaya ait tapınaklarla ilişkilerini gösteren görevli listeleri, idari belgeler, Assinnu ve Kurgarru adlı iki müzisyen sınıfının varlığına dair veri sunmakla birlikte kült kapsamındaki tören, bayram, kutlama gibi etkinliklerde üstlendikleri rolün de bilgisini içermektedir.Külte dair etkinliklerdeki varlıkları ve var olma biçimleri kadar cinsiyetleri ile ilgili geçen tanım ve bazıları radikal olan çeşitli ifadeler sebebiyle mensubu oldukları cinsiyet kimliğiyle de gündeme gelmişlerdir. Bu müzisyen/görevlilere dair bilgi veren belgelerde tanımlandıkları ifadeler ve icra ettikleri görevlere dair çeşitli betimlemeler, hadım (kastrati), eşcinsel, androjen, aracinsiyetli, hermafrodit (çift cinsiyetli), transseksüel (cinsiyet değiştirmiş), travesti, aseksüel, biseksüel, erkek kült fahişesi gibi tanımlamaların yapılmasına neden olmuştur.
Gerek külte dair etkinliklerde birden çok görevi üstlenmeleri gerekse decinsel kimliklerine dair geçen tanım ve ifadeler, görev tanımlarını ve cinsiyet temelinde kategorize edilmelerini zorlaştırmaktadır ki bu çalışmanın amacı, mevcut belgelerin incelenmesiyle mensubu oldukları cinsiyet ve külte ait faaliyetlerde üstlendikleri rolün anlaşılmasını sağlamaktır.
Signo y negatividad: una revolución saussuriana
Authors: Rastier François 
Published: March 2024

Saussure es el primer teórico occidental en hacer de la negatividad el fundamento de la definición misma de la unidad lingüística, rompiendo así con la positividad de las substancias, garantes de la referencia desde Aristóteles. Las consecuencias de esta ruptura, en lo que se refiere al modelo del signo, comienzan apenas a ser comprendidas a la luz de los manuscritos recientemente descubiertos. Ya no hay más clausura del signo y la semiótica responde, pues, a un principio de contextualidad. En un sentido más amplio, es la cultura la que es alcanzada por esta revolución conceptual que concierne incluso a la antropología filosófica.