bluuebunny/crossref_metadata_2025_split huggingface dataset:
Airway protection and outcomes after staged versus concurrent bilateral neck dissections with transoral base of tongue cancer resection
Authors: Lee Jake J. , Rapoport Nicholas A. , Pipkorn Patrik , Puram Sidharth V. , Jackson Ryan S. 
Published: February 2024

AbstractObjectivesTo assess airway, safety, and resource utilization outcomes between transoral base of tongue (BOT) surgery with staged versus concurrent bilateral neck dissections (BND).MethodsA retrospective cohort study of patients with human papilloma virus (HPV)‐related BOT cancer who underwent transoral surgery and BND from January 2015 through June 2022 was conducted. Free flap patients were excluded.ResultsOf 126 patients (46 [37%] staged and 80 [63%] concurrent BND), there were no significant differences in rates of postoperative intubation, tracheostomy, intensive care admission, operative takebacks, gastrostomy, and 30‐day readmission. Total operative time (median difference 1.4 [95% CI 0.9–1.8] hours), length of stay (1.0 [1.0–1.0] day), and time between primary surgery and adjuvant therapy initiation (4.0 [0.0–8.0] days) were lower in the concurrent BND cohort.ConclusionConcurrent BND alongside transoral BOT resection is safe with similar airway outcomes and lower total operative time, length of stay, and time to adjuvant therapy initiation compared to staged BND.
Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories
Authors: Wuestefeld Anika , Baumeister Hannah , Adams Jenna N. , de Flores Robin , Hodgetts Carl J. , Mazloum‐Farzaghi Negar , Olsen Rosanna K. , Puliyadi Vyash , Tran Tammy T. , Bakker Arnold , Canada Kelsey L. , Dalton Marshall A. , Daugherty Ana M. , La Joie Renaud , Wang Lei , Bedard Madigan L. , Buendia Esther , Chung Eunice , Denning Amanda , del Mar Arroyo‐Jiménez María , Artacho‐Pérula Emilio , Irwin David J. , Ittyerah Ranjit , Lee Edward B. , Lim Sydney , del Pilar Marcos‐Rabal María , Iñiguez de Onzoño Martin Maria Mercedes , Lopez Monica Munoz , de la Rosa Prieto Carlos , Schuck Theresa , Trotman Winifred , Vela Alicia , Yushkevich Paul , Amunts Katrin , Augustinack Jean C. , Ding Song‐Lin , Insausti Ricardo , Kedo Olga , Berron David , Wisse Laura E. M. 
Published: February 2024

AbstractThe medial temporal lobe (MTL) cortex, located adjacent to the hippocampus, is crucial for memory and prone to the accumulation of certain neuropathologies such as Alzheimer's disease neurofibrillary tau tangles. The MTL cortex is composed of several subregions which differ in their functional and cytoarchitectonic features. As neuroanatomical schools rely on different cytoarchitectonic definitions of these subregions, it is unclear to what extent their delineations of MTL cortex subregions overlap. Here, we provide an overview of cytoarchitectonic definitions of the entorhinal and parahippocampal cortices as well as Brodmann areas (BA) 35 and 36, as provided by four neuroanatomists from different laboratories, aiming to identify the rationale for overlapping and diverging delineations. Nissl‐stained series were acquired from the temporal lobes of three human specimens (two right and one left hemisphere). Slices (50 μm thick) were prepared perpendicular to the long axis of the hippocampus spanning the entire longitudinal extent of the MTL cortex. Four neuroanatomists annotated MTL cortex subregions on digitized slices spaced 5 mm apart (pixel size 0.4 μm at 20× magnification). Parcellations, terminology, and border placement were compared among neuroanatomists. Cytoarchitectonic features of each subregion are described in detail. Qualitative analysis of the annotations showed higher agreement in the definitions of the entorhinal cortex and BA35, while the definitions of BA36 and the parahippocampal cortex exhibited less overlap among neuroanatomists. The degree of overlap of cytoarchitectonic definitions was partially reflected in the neuroanatomists' agreement on the respective delineations. Lower agreement in annotations was observed in transitional zones between structures where seminal cytoarchitectonic features are expressed less saliently. The results highlight that definitions and parcellations of the MTL cortex differ among neuroanatomical schools and thereby increase understanding of why these differences may arise. This work sets a crucial foundation to further advance anatomically‐informed neuroimaging research on the human MTL cortex.
Venetoclax plus daunorubicin and cytarabine in newly diagnosed acute myeloid leukemia patients: A propensity score‐matched analysis
Authors: Wang Rong , Zhang Yi , Chang Jie , Wang Huafeng , Lou Yinjun , Yang Min , Xu Gaixiang , Tong Hongyan , Xie Wanzhuo , Zhou De , Wei Juying , Mai Wenyuan , Ye Xiujin , Meng Haitao , Jin Jie , Zhu Hong‐Hu 
Published: February 2024

AbstractVenetoclax plus 3 + 7 daunorubicin and cytarabine chemotherapy (DAV) has shown safety and efficacy in eligible patients with newly diagnosed acute myeloid leukemia (AML). However, there are no direct comparisons between DAV and 3 + 7 daunorubicin and cytarabine chemotherapy (DA) alone. We performed a propensity score‐matched analysis to compare the outcomes of DAV group with historical DA group and identify the clinical and molecular characteristics of patients who might benefit from the DAV regimen. The DAV group had a higher Complete remission (CR) rate than the DA group (90% vs. 55%, p = 0.008). 25 (96%) patients in the DAV group had a higher MRD‐negative CRc rate compared with 13 (62%) patients in the DA group (p = 0.006). After a median follow‐up duration of 19.15 (IQR 17.13–21.67) months, the DAV group had an improved overall survival (p = 0.001) and event‐free survival (p = 0.069), but not disease‐free survival (p = 0.136). Collectively, DAV regimen induced high CR rates and deep MRD‐negative CRc rates after one cycle of induction therapy, as well as prolonged the overall survival, in young adult patients with AML who were eligible for intensive chemotherapy. The addition of venetoclax to intensive chemotherapy should be considered in the future to achieve better survival advantages in eligible AML patients.
The moderating role of social capital for late‐career management intervention effects on older employees' work engagement
Authors: Jokisaari Markku , Ruokolainen Mervi , Vuori Jukka 
Published: February 2024

AbstractDespite increasing interest in supporting older workers' motivation, retention, and well‐being at work, knowledge about how social networks at work may affect the efficacy of training interventions among older employees is scarce. These social ties are an important source of resources for older workers' careers. This study examined the characteristics of older workers' personal social networks as boundary conditions for the effects of late‐career management intervention on work engagement. Data were used from an earlier randomized controlled trial (RCT) in which senior employees (mean age of 58 years) participated in a peer group‐based training intervention and were asked to complete follow‐up surveys at baseline, post‐intervention, and after 6 months (Vuori et al., 2019, Journal of Vocational Behavior, 115: 103327). The results showed that older workers' social ties at higher organizational levels (upper reachability) and the number of social ties at work moderated the effect of the intervention on work engagement. Specifically, the intervention aimed at enhancing employees' personal resources improved work engagement for senior employees with few or no social ties at work with whom they could discuss important matters, and for those with social ties at higher organizational levels. However, the relationship quality between older workers and their leaders showed no moderation effect. This study encourages human resources professionals to consider the social network characteristics and peer learning of older workers when providing training to enhance their work engagement.
Using college readers' eye movements to discuss textbook reading strategies
Authors: Paulson Eric J. , Holschuh Jodi Patrick , Lampi Jodi P. 
Published: February 2024

AbstractIn order to better understand whether and how college students use certain textbook reading strategies, this project employed several important methods in concert, including a textbook reading strategy inventory that focused on frequency of strategy use, eye‐movement recordings of participants reading college textbook excerpts, and think‐aloud sessions in which participants viewed their own eye‐movement recordings and used them as a stimulus to engage in a structured retrospective think‐aloud about their own reading approach and strategies. Salient findings include participants' emerging articulations about the observable reading strategies they identified themselves implementing, discrepancies in their assumptions about their reading strategies and what they actually employed, and the sometimes surprising (to the participant) strategies they used to navigate these textbook excerpts.
Social and emotional well‐being and economic insecurity of Aboriginal and Torres Strait Islanders: A multidimensional approach
Authors: Kumar Sanjesh , Ray Ranjan 
Published: February 2024

AbstractThis study examines the relative deprivation in the mental health, henceforth referred to as ‘social and emotional well‐being (SEWB)’, of Aboriginal and Torres Strait Islander people in relation to non‐Aboriginal and Torres Strait Islanders. The study uses the multidimensional deprivation methodology to quantify the deprivation in SEWB. The results show wide variation in the relative deprivation of the Aboriginal and Torres Strait Islanders people between the dimensions of SEWB. This study finds robust evidence that the Aboriginal and Torres Strait Islander people experience lower SEWB and higher economic insecurity than the rest and the gap refuses to narrow over time.
Genotype, cervical intraepithelial neoplasia, and type‐specific cervical intraepithelial neoplasia distributions in hrHPV+ cases referred to colposcopy: A multicenter study of Chinese mainland women
Authors: Chen Mingyang , Ye Zichen , Wang Huike , Cui Xiaoli , Seery Samuel , Wu Aiyuan , Xue Peng , Qiao Youlin 
Published: February 2024

AbstractTo investigate age and type‐specific prevalences of high‐risk human papillomavirus (hrHPV) and cervical intraepithelial neoplasia (CIN) in hrHPV+ women referred to colposcopy. This is a retrospective, multicenter study. Participants were women referred to one of seven colposcopy clinics in China after testing positive for hrHPV. Patient characteristics, hrHPV genotyping, colposcopic impressions, and histological diagnoses were abstracted from electronic records. Main outcomes were age‐related type‐specific prevalences associated with hrHPV and CIN, and colposcopic accuracy. Among 4419 hrHPV+ women referred to colposcopy, HPV 16, 52, and 58 were the most common genotypes. HPV 16 prevalence was 39.96%, decreasing from 42.57% in the youngest group to 30.81% in the eldest group. CIN3+ prevalence was 15.00% and increased with age. As lesion severity increases, HPV16 prevalence increased while the prevalence of HPV 52 and 58 decreased. No age‐based trend was identified with HPV16 prevalence among CIN2+, and HPV16‐related CIN2+ was less common in women aged 60 and above (44.26%) compared to those younger than 60 years (59.61%). Colposcopy was 0.73 sensitive at detecting CIN2+ (95% confidence interval[CI]: 0.71, 0.75), with higher sensitivity (0.77) observed in HPV16+ women (95% CI: 0.74, 0.80) compared to HPV16− women (0.68, 95% CI: 0.64, 0.71). Distributions of hrHPV genotypes, CIN, and type‐specific CIN in Chinese mainland hrHPV+ women referred to colposcopy were investigated for the first time. Distributions were found to be age‐dependent and colposcopic performance appears related to HPV genotypes. These findings could be used to improve the management of women referred to colposcopy.
The characteristics of BCR‐CDR3 repertoire in COVID‐19 patients and SARS‐CoV‐2 vaccinated volunteers
Authors: Xiao Jiaping , Luo Yan , Li Yangyang , Yao Xinsheng 
Published: February 2024

AbstractThe global COVID‐19 pandemic has caused more than 1 billion infections, and numerous SARS‐CoV‐2 vaccines developed rapidly have been administered over 10 billion doses. The world is continuously concerned about the cytokine storms induced by the interaction between SARS‐CoV‐2 and host, long COVID, breakthrough infections postvaccination, and the impact of SARS‐CoV‐2 variants. BCR‐CDR3 repertoire serves as a molecular target for monitoring the antiviral response “trace” of B cells, evaluating the effects, mechanisms, and memory abilities of individual responses to B cells, and has been successfully applied in analyzing the infection mechanisms, vaccine improvement, and neutralizing antibodies preparation of influenza virus, HIV, MERS, and Ebola virus. Based on research on BCR‐CDR3 repertoire of COVID‐19 patients and volunteers who received different SARS‐CoV‐2 vaccines in multiple laboratories worldwide, we focus on analyzing the characteristics and changes of BCR‐CDR3 repertoire, such as diversity, clonality, V&J genes usage and pairing, SHM, CSR, shared CDR3 clones, as well as the summary on BCR sequences targeting virus‐specific epitopes in the preparation and application research of SARS‐CoV‐2 potential therapeutic monoclonal antibodies. This review provides comparative data and new research schemes for studying the possible mechanisms of differences in B cell response between SARS‐CoV‐2 infection or vaccination, and supplies a foundation for improving vaccines after SARS‐CoV‐2 mutations and potential antibody therapy for infected individuals.
Incidence of nausea/vomiting following propofol sedation with adaptive servo‐ventilation for atrial fibrillation ablation
Authors: Sakanoue Haruna , Yamaji Hirosuke , Okamoto Sayaka , Okano Kumi , Fujita Yuka , Higashiya Shunichi , Murakami Takashi , Kusachi Shozo 
Published: February 2024

AbstractBackgroundPostoperative nausea and vomiting (PONV) following atrial fibrillation (AF) ablation can cause considerable distress.AimContinuous intravenous propofol sedation with adaptive servo‐ventilation (ASV) with or without an analgesic, pentazocine, during AF ablation was studied in 272 consecutive patients with paroxysmal, persistent, and long‐standing persistent AF. The study objectives were to determine the incidence of PONV after AF ablation and to assess the predictive value of factors for PONV using the area under the receiver operating characteristic curve (AUC).ResultsThe present sedation maneuver was successfully accomplished with a low incidence of hypotension and without discontinuation of ablation or switching to general anesthesia, while maintaining an acceptable procedural time (102 ± 32 min). The incidence of PONV was 5.5% (15/272). Nausea occurred in nine patients after an average of 4.6 ± 3.5 h (range: 2–12 h) postablation, and vomiting with nausea occurred in six patients after an average of 4.5 ± 3.1 h (range: 1–9 h) postablation. The postablation interval did not differ significantly between the occurrence of nausea and nausea accompanied by vomiting. AUCs based on various factors, including the Apfel score, ranged from 0.55 to 0.67, indicating low accuracy in predicting PONV occurrence.ConclusionsThe incidence of PONV after propofol sedation with ASV was the lowest (5.5%) reported to date. Scoring systems, which included the Apfel score, were ineffective in predicting PONV. The low PONV incidence in addition to the efficacy of propofol sedation with ASV revealed the adequacy of this regimen for AF ablation.
Inherited terrestrial cosmogenic nuclides in landscapes of selective glacial erosion: lessons from Lochnagar, Eastern Grampian Mountains, Scotland
Authors: Hall Adrian M. , Sugden David E. , Binnie Steven A. , Hein Andy , Dunai Tibor , Ritter Benedikt , Stewart Margaret 
Published: February 2024

ABSTRACTInheritance from prior exposure often complicates the interpretation of terrestrial cosmogenic nuclide (TCN) inventories in glaciated terrain. Lochnagar, a mountain in eastern Scotland, holds a clear geomorphological record of corrie glaciation and the thinning of the last Scottish ice sheet over the last ~15 ka. Yet attempts to date the main stages in deglaciation after sampling of 21 granite boulders for 10Be, 26Al and 14C from corrie moraines, an ice sheet lateral moraine and boulder spreads revealed widespread, but variable, TCN inheritance. Only the youngest boulder ages fit within the range of expected deglaciation ages. To identify the sources of geological uncertainty, we provide simple models of ice cover duration and erosion histories for plateau, corrie and strath landscape domains, identify the variable nuclide inheritance that derives from different sources for boulders in these domains, and outline the effects of rotation, splitting and erosion of boulders during glacial transport. The combined effects increase clustering around arbitrary mean TCN values that exceed deglaciation ages. A further implication is that boulders have survived beneath overriding ice sheets. Such boulder trapping at Lochnagar may have resulted from topographic controls on katabatic winds and surface ablation acting on a thinning, cold‐based ice sheet.
Analyzing Gene Expression After Administration of Low‐Intensity Therapeutic Ultrasound in Human Islet Cells
Authors: Hill John , Messina James , Jeremic Aleksandar , Zderic Vesna 
Published: February 2024

ObjectivesDiabetes mellitus is a complex heterogenous metabolic disease that significantly affects the world population. Although many treatments exist, including medications such as metformin, sulfonylureas, and glucagon‐like peptide‐1 (GLP) receptor agonist, there is growing interest in finding alternative methods to noninvasively treat this disease. It has been previously shown that low‐intensity ultrasound stimulation of pancreatic β‐cells in mice can elicit insulin secretion as a potential treatment for this disease. This is desirable as therapeutic ultrasound has the ability to induce bioeffects while selectively focusing deep within tissues, allowing for modulation of hormone secretion in the pancreas to mitigate insufficient levels of insulin.MethodsExactly 800 kHz ultrasound with intensity 0.5 W/cm2 was administered 5 minutes continuously, that is, 100% duty cycle, to donor pancreatic human islets, followed by 1 hour incubation and RT‐qPCR to assess the effect of ultrasound stimulation on gene expression. The genes were insulin (INS), glucagon (Glu), amylin (Amy), and binding immunoglobulin protein (BiP). Nine donor pancreatic human islets were used to assess insulin and glucagon secretion, while eight samples were used for amylin and BiP. Fold change (FC) was calculated to analyze the effect of ultrasound stimulation on the gene expression of the donor islet cells. High‐glucose and thapsigargin‐treated islets were utilized as positive controls. Cell viability testing was done using a Trypan Blue Exclusion Test.ResultsUltrasound stimulation did not cause a statistically significant upregulation in any of the tested genes (INS FC = 1.15, P‐value = .5692; Glu FC = 1.60, P‐value = .2231; Amy FC, P‐value = .2863; BiP FC = 2.68, P‐value = .3907).ConclusionsThe results of this study show that the proposed ultrasound treatment parameters do not appear to significantly affect gene expression of any gene tested.
Gender‐based differences exist in the functional knee phenotypes classification of the osteoarthritic knee
Authors: Chelli Sabrina , Rudyy Taras , Avram George Mihai , Huegli Rolf W. , Amsler Felix , Hirschmann Michael T. 
Published: February 2024

AbstractPurposeTo identify gender differences in (1) the coronal alignment of functional knee phenotypes and (2) the JLCA (joint line convergence angle) in relation to the phenotype classification.MethodsThis study is a retrospective data analysis, including 12,099 osteoarthritic knee computed tomography (5025 male, 7074 female) analysed by Medacta software for hip‐knee‐ankle angle (HKA), femoral mechanical angle (FMA), tibial mechanical angle (TMA) and JLCA. The data were grouped into genders and combined according to the Functional Knee Phenotypes Classification.ResultsOut of 127 phenotypes for males and 131 for females, 17 common phenotypes were reported. The commonest four were similar for both genders with VARHKA177° NEUFMA93° NEUTMA87° (9.8% males, 9.50% females), followed by VARHKA174° NEUFMA93°VARTMA84° (7.1%) and VARHKA174°VARFMA90° NEUTMA87° (7.0%) for males and VARHKA174° NEUFMA93° NEUTMA87° (6.1%), VARHKA174° NEUFMA93°VARTMA84° (5.1%) for females. The commonest FMA and TMA (91.5° to 94.5° and 85.5° to 88.5°, respectively) were the same for both genders, however, the rest of the male population observed greater femoral varus than the female population (p < 0.001). JLCA values ranged from −28.4° to 8.2° in the overall study population. Males and females had a mean JLCA of −2.96° (±2.6° SD) and −2.66° (±2.8°7 SD), respectively, p < 0.001.ConclusionsGender differences exist within the osteoarthritic knee phenotype. The male varus phenotype is influenced by FMA, while TMA values are similar across genders. JLCA variations show similarities to both TMA and FMA, suggesting JLCA is influenced by bone morphology more than by gender. These differences inform surgical decision‐making for the personalised approach to the primary TKA.Level of EvidenceLevel III.
Higher conversion rate to knee arthroplasty in female patients following medial open‐wedge high tibial osteotomy
Authors: Ahrend Marc‐Daniel , Petzold Daniel , Schuster Philipp , Herbst Moritz , Ihle Christoph , Mayer Philipp , Schröter Steffen 
Published: February 2024

AbstractPurposeMost studies about medial open‐wedge high tibial osteotomy (HTO) reported outcomes without focusing on gender differences. Therefore, the study compared the long‐term survival rate and postoperative subjective knee function after HTO in female versus male patients with symptomatic medial compartment knee osteoarthritis.MethodsThe data of three cohorts with long‐term outcomes were analysed (n = 245; 32% females; age: 49 ± 7 years; Kellgren Lawrence Grade I 6.1%, II 32.7%, III 42.4%; IV 18.8%). The minimum follow‐up was at least 6 years or an earlier conversion to total knee arthroplasty (TKA). The gender‐specific survival rate after HTO was calculated after 5 and 10 years and compared using Kaplan–Meier analysis and the logrank test. Baseline characteristics and subjective knee function (International Knee Documentation Committee [IKDC]/Lysholm) were analysed between both genders.ResultsForty of 78 (51.3%) women and 41 of 167 men (24.5%) underwent TKA. HTO survival in females was significantly lower (p = 0.0010). The 5‐ and 10‐year survival rates were 85.9% and 62.6% for females and 93.4% and 77.7% for males. In females and males, from preoperative to the last follow‐up, the IKDC (43 ± 15 to 58 ± 17; 47 ± 14 to 67 ± 18) and the Lysholm (42 ± 18 to 72 ± 18; 55 ± 22 to 77 ± 23) improved significantly (all p < 0.0001). Females had significantly lower preoperative and postoperative IKDC (p = 0.0438; p = 0.0035) and Lysholm scores (p = 0.0002; p = 0.0323). But the absolute improvements of the IKDC and Lysholm were not significantly different between genders.ConclusionsFemales had higher conversion rates to TKA and lower knee function at the last follow‐up. However, preoperative knee function was lower in females and the absolute improvement following HTO was similar for both genders. In general, females benefit from HTO to treat medial knee arthritis, and TKA could be postponed for half of female patients for more than 10 years. However, surgeons must be aware of the described inferior outcomes in females for realistic patient expectation management.Level of EvidenceLevel II.