bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic Glucocorticosteroid Therapy of Skin Disease in Children
Authors: Fritz Karen A. , Weston William L. 
Published: March 2008

Abstract:The role of systemic glucocorticosteroid therapy in the managetnent of dermatologic disorders in children is limited. Most skin diseases requiring the antiinflammatory or antiproliferative effects of steroids are best managed with topical preparations, because they exert local effects almost exclusively and cause few if any systemic side effects when used properly. There are, however, certain skin diseases, which because of their severity or their intrinsic nature, do not respond adequately to these agents. We propose the indications for pharmacologic doses of systemic glucocorticosteroids in dermatologic disease, the preferred route of administration, the most common as well as the more rare side effects of this therapy. Withdrawal of patients from chronic use of these drugs is also discussed.
Cat–scratch Disease: A Review of the Literature
Authors: Shinall Elizabeth Anne 
Published: March 2008

AbstractCat–scratch disease (CSD) is a common cause of chronic lymphadenopathy (especially regional) that primarily affects children and adolescents. The clinical diagnosis of CSD is based on the presence of three of four criteria, which may inciude a positive CSD skin test. Usuaily a benign, self–limiting disease, CSD may sometimes have atypical manifestations and serious complications, particuiarly in tmmunocompromised hosts. Cat–scratch disease is now known to be caused by a smail, gram–negative, pleomorphic bacterium. Antibiotics are dramatically effective against CSD in immunocompromised patients, and are of proven benefit in typical cases. Most patients recover with only symptomatic treatment. This article reviews the history of CSD research, oiinicai features of typical and atypical CSD, and current topics of interest in CSD research, especiaily in the areas of diagnosis and treatment.
Childhood Psoriasis: An Epidemiologic Survey of 112 Patients
Authors: Nanda Arti , Kaur Surrinder , Kaur Inderjeet , Kumar Bhushan 
Published: March 2008

AbstractOne hundred and twelve cases of chitdhood psoriasis, constituting 5% of all psoriasis patients registered in our ciinic, were studied over a period of nine years (January 1980 to December 1988). There were 57 male and 55 female patients. Age of onset ranged from 1 month to 13 years, with a mean and median age of 7 years. A positive famiiy history of psoriasis was elicited from 9.8% of patients. The commonest form of psoriasis found was plaque (89.6%), followed by guttate (25.9%). Infection was the most common triggering factor, occurring in 15.2% of cases. Many of these findings are at variance with observations reported elsewhere for this age group.
Structural Hair Abnormalities in Ectodermal Dysplasia
Authors: Micali Giuseppe , Cook Brian , Blekys Irene , Solomon Lawrence M. 
Published: March 2008

AbstractThe hair of patients with three ectodermal dysplasias–ectrodactyly ectodermal dysplasia clefting syndrome (EEC); orofacial–digital syndrome (OFD) type I; and anhidrotic ectodermal dysplasia syndrome (AED)– were studied by scanning electron microscopy. While no pathognomonic abnormalities were noted for each condition, hair shaft structural defects were evident in all patients studied. The EEC clefting syndrome and OFD I shared the most deforming defects, while AED had fewer.
Lymphomatoid Papulosis with Antigen Deletion and Clonal Rearrangement in a 4‐Year‐Old Boy
Authors: Hellman Judith , Phelps Robert G. , Baral Jim , Fasy Thomas M. , Ahern Caitlin M. , Strauchen James A. 
Published: March 2008

AbstractLymphomatoid papulosis (LyP) is rarely seen in children. We report a case of LyP in a 4‐year‐old boy in whom immunopathologic studies demonstrated T cell antigen deletions. In contrast to all but two previous reports, a T suppressor (CD‐8) phenotype was predominant. Southern blot analysis of DNA isolated from a typical skin lesion indicated a clonal rearrangement of the T cell receptor β gene. Because of a 10% frequency of malignant lymphomas in patients with LyP, long‐term observation is cruciai, especially in chiidren. We recommend routine clonal rearrangement studies for aid in diagnosis and follow‐up, and as possible prognostic indicators in children with this condition.
Benign Neonatal Hemangiomatosis: Review and Description of a Patient with Unusually Persistent Lesions
Authors: Held Jonathan L. , Haber Robert S. , Silvers David N. , Grossman Marc E. 
Published: March 2008

AbstractBenign neonatal hemangjomatosis (BNH) is a disorder in which multiple cutaneous hemangiomas appear at birth or shortly thereafter; visceral complications are absent. While previously reported cases of BNH emphasize the relatively earty spontaneous regression of the cutaneous lesions, we describe a patient in whom new lesions arose and old ones persisted during the first year of life. The features of BNH are contrasted with those of diffuse neonatal hemangiomatosis (DNH), a dermatosis with a more grave prognosis.
Blue Rubber Bleb Nevus Syndrome: Laser Photocoagulation of Colonic Hemangiomas in a Child with Microcytic Anemia
Authors: Morris Laura , Lynch Patrick M. , Gleason Wallace A. , Schauder Craig , Pinkel Donald , Duvic Madeleine 
Published: March 2008

Abstract:This is a case report and review of the literature on the blue rubber bleb nevus syndrome. The clinical features of the syndrome are discussed, with emphasis on chronic gastrointestinal bleeding and resulting anemia. A new therapeutic modality, colonoscopy with laser photocoagulation, is recommended as a safe, effective, and less invasive method of controlling bleeding from colonic hemangiomas than surgical resection and repeated transfusions. This technique is less helpful for patients with prominent involvement of the small intestine.
Eruptive Vellus Hair Cysts: Case Report and Review of the Literature
Authors: Grimalt Ramon , Gelmetti Carlo 
Published: March 2008

Abstract:A 6‐year‐old Caucasian girl had dozens of asymptomatic, flesh‐colored, 2‐ to 5‐mm eruptive vellus hair cysts. These papules on the buttocks, thighs, and groin increased in number for three months. Histologic examination revealed poorly defined, keratin‐filled cysts in the upper middermis, containing numerous transversely or obliquely cut portions of vellus hair. The histopathologic differential diagnosis with other epithelial cysts containing hair shafts is debated, and new clinical differential diagnoses are proposed. Review of the literature suggests that eruptive vellus hair cyst is not a rare disorder, but its frequency is probably underestimated due to paucity of symptoms. Nevertheless, the clinical relevance of some of the differential diagnoses should convince clinicians to obtain histologic confirmation.
Infantile Condylomata of the Oral Cavity
Authors: Paradisi M. , Mostaccioli S. , Celano G. , Angelo C. , Ruatti P. , Muda A. Onetti , Faraggiana T. 
Published: March 2008

Abstract:A child had condylomata acuminata localized to the oral cavity. Main points of interest were this exclusive localization, the extremely high number of papillary lesions, not reported in the literature until now, and the excellent response to interferon and local applications of podophyllin. Histologic, ultrastructural, and in situ molecular hybridization techniques were performed to make a correct diagnosis. Transmission of the etiolgic agent and therapeutic approaches are discussed.
Focal Dermal Hypoplasia (Goltz Syndrome): Report of Two Cases with Minor Cutaneous and Extraeutaneous Manifestations
Authors: Pujol R. M. , Casanova J. M. , Pérez M. , Matias‐Guiu X. , Planagumà M. , De Moragas J. M. 
Published: March 2008

Abstract:Two women, ages 33 and 16 years, had focal dermal hypoplasia (Goltz syndrome) with unusual, minimal clinical manifestations. The lesions consisted of patchy, atrophic, scaly, telangiectatic macules arranged in a linear pattern along Blaschko's lines, involving the anterior and lateral aspects of both legs (patient 1) and the anterolateral aspect of the left leg (patient 2), Type I partial syndactyly involving the second and the third toes in both patients was also present. The clinical and histopathologic features and diagnostic difficulties of cases of this disorder with minimal cutaneous and extraeutaneous manifestations are discussed.
Unusual Physiologic Melanin Pigmentation of the Tongue
Authors: Anavi Yakir , Mintz Sheldon 
Published: March 2008

Abstract:A patient had extensive congenital oral hyperpigmentation of the tongue. The clinical and histologic features set this case apart from any well‐delineated disease. Clinically, the congenital onset, the appearance of large black‐brownish lesions, the lack of associated systemic abnormalities, and the histologic findings of prominent deposition of melanin In the basal layer support the diagnosis of physiologic melanosis. The macular lesions of the tongue represent discrete depositions of melanin and exemplify soft tissue pigmentation of developmental origin.
Crouzon Disease with Acanthosis Nigricans and Melanocytic Nevi
Authors: Ginés Elena , Rodriguez‐Piehardo Antonio , Jorquera Enrique , Moreno Jose Carlos , Camacho Francisco 
Published: March 2008

Abstract:A number of craniofacial malformation syndromes are characterized by prominent abnormalities of the skin, hair, nails, and mucous membranes. Crouzon disease has been reported in association with severe acanthosis nigricans in 12 patients. We report a new case of this association in a 16‐year‐old woman with multiple melanocytic nevi. Melanocytic nevi have been already reported in the medical literature in association with several congenital syndromes, although, to our knowledge, not with Crouzon disease.
Phakomatosis Pigmentovascularis: Report of a Case
Authors: Mahroughan M. , Mehregan Amir H. , Mehregan David A. 
Published: March 2008

Abstract:Phakomatosis pigmentovascularis is a rare cutaneous malformation characterized by a combination of melanocytic nevi and nevus flammeus. We report a 16‐year‐old boy with extensive and predominantly unilateral skin involvement combining features of speckled melanocytic nevi over a background of nevus flammeus. A brief review of the literature and classification of this phakomatosis is presented.
Neonatal Acute Hemorrhagic Edema of Childhood: Case Report and Review of the English‐Language Literature
Authors: Cunningham Bari B. , Caro William A. , Eramo Lynne R. 
Published: March 2008

Abstract:Acute hemorrhagic edema of childhood is an unusual form of leukocytoclastic vasculitis previously reported in children age 4 months to 3 years. The etiology remains unknown, however, many authors describe the process as an immune‐mediated vasculitis in response to a variety of antigenic stimuli. We report a case of congenital acute hemorrhagic edema of childhood associated with maternal gastroenteritis six weeks before delivery.
Iododerma: An Unusual Side Effect of Iodide Ingestion
Authors: Alpay Koksal , Kürkçüoǧlu Nazif 
Published: March 2008

Abstract:A 13‐month‐old girl developed multiple pruritic, 1‐ to 7‐cm, vegetating and ulcerative masses on the neck, extremities, and trunk after a one‐week course of an antibiotic and an expectorant that contained potassium iodide, prescribed for treatment of a respiratory tract infection. Clinical and histopathologic findings were consistent with the diagnosis of iododerma. A thorough search for an underlying disease was negative. On cessation of potassium iodide and administration of oral prednisolone 1 mg/kg/day, a dramatic response was achieved.
Environmental Impact and Added Value in Forestry Operations in Norway
Authors: Michelsen Ottar , Solli Christian , Strømman Anders Hammer 
Published: March 2008

SummaryThe forestry sector is experiencing an increasing demand for documentation about its environmental performance. Previous studies have revealed large differences in environmental impact caused by forestry operations, mainly due to differences in location and forestry practice. Reliable information on environmental performance for forestry operations in different regions is thus important. This article presents a case study of forestry operations in Norway. Environmental impact and value added of selected operations were assessed. This was done with a hybrid life cycle assessment (LCA) approach. Main results, including a sensitivity analysis, are presented for a set of four impact categories. The production chain assessed included all processes from seedling production to the delivery of logs to a downstream user. The environmental impact was mainly caused by logging, transport by forwarders, and transport by truck. These three operations were responsible for approximately 85% of the total environmental impact. The contribution to value added and total costs were more evenly distributed among the processes in the value chain. The sensitivity analysis revealed that the difference in environmental impact between the worst case scenario and the best case scenario was more than a factor of 4. The single most important process was the transport distance from the timber pile in the forest to the downstream user. The results show that the environmental impact from forestry operations in boreal forests was probably underreported in earlier studies.
Dynamic Eco‐Efficiency Projections for Construction and Demolition Waste Recycling Strategies at the City Level
Authors: Bohne Rolf André , Brattebø Helge , Bergsdal Håvard 
Published: March 2008

SummaryIn this article we have elaborated a consistent framework for the quantification and evaluation of eco‐efficiency for scenarios for waste treatment of construction and demolition (C&D) waste. Such waste systems will play an increasingly important role in the future, as there has been for many years, and still is, a significant net increase in stock in the built environment. Consequently, there is a need to discuss future waste management strategies, both in terms of growing waste volumes, stricter regulations, and sectorial recycling ambitions, as well as a trend for higher competition and a need for professional and optimized operations within the C&D waste industry. It is within this framework that we develop and analyze models that we believe will be meaningful to the actors in the C&D industry. Here we have outlined a way to quantify future C&D waste generation and have developed realistic scenarios for waste handling based on today's actual practices. We then demonstrate how each scenario is examined with respect to specific and aggregated cost and environmental impact from different end‐of‐life treatment alternatives for major C&D waste fractions. From these results, we have been able to suggest which fractions to prioritize, in order to minimize cost and total environmental impact, as the most eco‐efficient way to achieve an objective of overall system performance.
Flexible Product Development: Building Agility for Changing Markets by Preston G. Smith
Authors: Nelson Beebe 
Published: March 2008

Books reviewed in this issue:

Flexible Product Development: Building Agility for Changing Markets
The Leader's Guide to Lateral Thinking Skills: Unlocking the Creativity and Innovation in You and Your Team
Service Is Front Stage: Positioning Services for Value Advantage
Involving Customers in New Service Development
Project Sponsorship: Achieving Management Commitment for Project Success

Please note that the editor in chief of the Journal of Product Innovation Management (JPIM), Anthony Di Benedetto, was solely responsible for all editorial work on the first book review, since this is an assessment of the newest book by JPIM's book review editor, Preston Smith. To assure objectivity in the review process, Di Benedetto identified the reviewer, solicited and edited the review, and submitted the accepted review directly to the publisher. Smith did not see the review until it was completed and accepted for publication.
A new technique to in vivo study the corneocyte features at the surface of the skin
Authors: Lévêque Jean Luc , François Ghislain , Sojic Neso , Giron Franck 
Published: March 2008

Purpose of the study: To design, develop and validate a new device allowing the features of corneocytes at the surface of the skin to be visualized in vivo and objectively characterized.Materials and methods: Monochromatic light is focused at the proximal end of a coherent bundle of optical fibres. Fluorescence of skin, stained with fluorescein, is then captured by the same fibre bundle and displayed, through a dichroic mirror, by a CCD camera. Fluorescence images are analysed using dedicated software to measure the projected area of cells.Results: The new device allows the mean projected area of corneocytes to be routinely studied and quantified on most of the skin areas of the human body. Measurements carried out on two age groups of women confirm that corneocyte size on the forearm is smaller in young women than in older women.Conclusion: The new non‐invasive device is easy to use and appear quite appropriate for cutaneous investigations carried out in clinical research.
Body Mass Index and its Association with Genitourinary Disorders in Men Undergoing Prostate Cancer Screening
Authors: Bhojani Naeem , Perrotte Paul , Hutterer Georg , Suardi Nazareno , Jeldres Claudio , Shariat Shahrokh F. , Capitanio Umberto , Arjane Philippe , Widmer Hugues , Benard Francois , Peloquin Francois , Montorsi Francesco , Karakiewicz Pierre 
Published: March 2008

ABSTRACT

Introduction
Elevated body mass index (BMI) may predispose to several pelvic pathologies.

Aims
We tested the association between BMI and five end points, namely, (i) erectile dysfunction (ED); (ii) lower urinary tract symptoms (LUTS); (iii) chronic prostatitis-associated pain (CPP); and ejaculatory dysfunction that is subdivided between (iv) pain/discomfort on ejaculation; and (v) subjectively decreased ejaculate volume.

Methods
Age, height, and weight were prospectively recorded in a cohort of 590 consecutive healthy men undergoing prostate cancer screening. Continuously coded and categorized BMI (World Health Organization classification) were studied.

Main Outcome Measures
Age-adjusted analyses relied on logistic and linear regression models, according to data type.

Results
The average age was 54.1 years (range 30–83). Of all, 296 were overweight (50.2%, BMI 25–29.9 kg/m2) and 85 were obese (14.4%, BMI ≥ 30 kg/m2). After age adjustment, elevated continuously coded BMI (P &lt; 0.001) and elevated categorized BMI (P = 0.01) were associated with worse erectile function. Conversely, after age adjustment, elevated continuously coded BMI (P = 0.02) and elevated categorized BMI (P = 0.05) were associated with a lower rate of subjectively decreased ejaculate volume. Finally, after age adjustment, elevated categorically coded BMI was related to lower rates of CPP (P &lt; 0.001) and to a lower rate of pain/discomfort on ejaculation (P = 0.03).

Conclusions
In men undergoing prostate cancer screening, the effect of BMI on the five end points is not invariably detrimental. Elevated BMI may predispose to ED, but may also decrease the rate of pain/discomfort on ejaculation and may lower the reported rate of subjectively decreased ejaculate volume. Finally, it appeared to have no effect on LUTS.
Sexual Attitude and Perception on Sexual Relationship Among Long-Term Users of Sildenafil
Authors: Kim Sae-Chul 
Published: March 2008

ABSTRACT

Introduction
High discontinuation rates of sildenafil were reported in its respdonders.

Aim
To investigate perception on and attitude toward sex among long-term users of sildenafil

Methods
A survey was conducted using random face-to-face interviews and a structured questionnaire on a population of 105 long-term sildenafil users (mean age; 57.8 years), who first took sildenafil 5 years or more previously and continued its use in the previous 6 months.

Main Outcome Measures
Six point-scale of perception on and attitude toward sex and valuation of sildenafil.

Results
Among the long-term users, 98% perceived that it is desirable to have sex even though they get old if they are healthy, 93% had a positive attitude toward sex, and 97% had an intercourse-focused perception of sexual relationship; these rates were higher for those with a lower income and less education. And 59% had intercourses and 40% took sildenafil one to two times a week. They ranked prominence in rigidity of erection as the major reason for the long-term sildenafil use. The rigidity was maintained after more than 5-year use.

Conclusion
An overall majority of the long-term users of sildenafil had a positive attitude toward sex, an active sexual behavior, and an intercourse-focused perception on sexual relationship. Sildenafil provided an optimal fit for the patients' needs. Prominence in rigidity of erection was ranked as the major reason for the long-term use.
The Impact of Lower Urinary Tract Symptoms and Urinary Incontinence on Female Sexual Dysfunction Using a Validated Instrument
Authors: Cohen Brian L. , Barboglio Paholo , Gousse Angelo 
Published: March 2008

Abstract

Introduction
Lower urinary tract symptoms (LUTS) is a common problem in women and frequently coexists with female sexual dysfunction (FSD). However, the relationship of LUTS and FSD is poorly characterized.

Aim
To evaluate the relationship of LUTS and urinary incontinence (UI) to FSD using a validated instrument, the female sexual function index (FSFI).

Methods
We performed an institutional review board-approved retrospective evaluation of 236 female patients over a 3-year time-period who completed an FSFI-validated questionnaire and underwent urodynamics (UDS) evaluation for LUTS or UI. Patients were categorized based upon history and physical exam into different LUTS groups. Additionally, the presence or absence of UI, detrusor overactivity (DO), stress urinary incontinence, and maximal cystometric capacity (MCC) &gt; or &lt;200 mL on UDS were used to further evaluate these patients. FSFI domain and total scores were compared between the different LUTS groups.

Main Outcome Measure
FSFI scores were evaluated for women with similar clinical LUTS diagnosis and UDS findings. The Kruskal–Wallis nonparametric test and the Dwass–Steel test determined statistical significance and performed multiple pairwise comparisons between the different voiding dysfunction groups and those with normal UDS (Leak-/DO-/urodynamic stress incontinence-).

Results
The mean age of the cohort was 49.5 (range 18–69), and there was no statistically significant difference in mean age within each LUTS subgroup. MCC&lt;200 mL did not significantly impair female sexual function. Patients with clinical diagnosis of overactive bladder (OAB)-Dry had the highest sexual function while those with mixed urinary incontinence had the worst. Additionally, women with UI and DO had the greatest degree of FSD, which was significantly worse than those with normal UDS. Additionally, for women with or without UI, the presence of DO on UDS resulted in a trend toward worse sexual function.

Conclusions
The sexual function of women is negatively impacted by the presence of LUTS, with UI and DO causing the greatest degree of FSD. The sexual domains most affected are desire, lubrication, orgasm, and sexual satisfaction.