bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanistic Insight into Binding of Graphene Towards Multiple Therapeutic Target of SARS-CoV-2 by Molecular Docking and Dynamics Studies
Authors: Savita Aman , Gupta Hariom , Patidar Rajesh 
Published: April 2024

Background:
Even after more than three years of emergence of coronavirus diseases 2019
(COVID-19), it remains incurable, despite the use of emergency-approved vaccines. The impact of
the emergency-approved vaccines against it is not highly certain. The entire world may face surge of
new wave of the infection, and therefore, its reoccurrence cannot be denied. Causalities and economic
losses may happen in the future. In this situation, it is need of the hour to explore some suitable
therapeutic agents against this highly infectious and challenging disease. Organic molecules, inactivated
virus etc were largely focused to derive the vaccines, however, nanomaterials still remain untested
for it. Interaction of nanomaterials like graphene against proteins of the coronavirus to inhibit
its activity is yet to be tested computationally.

Methods:
In this computational research work, graphene is tested for interaction with the viral proteins,
as the dimension of the novel coronavirus also belongs to nano-scale (diameter 65-125 nm). A
detailed study ondocking structures and molecular dynamics between viral proteins and graphene, is
undertaken. Autodock and Discovery Studio packages were used for docking calculations and interaction
analysis, respectively. Molecular dynamics simulation was performed using NAMD software
and obtained results were visualized using VMD software.

Results:
Range of proteins of the coronavirus including spike proteins (both open and closed form),
Main Protease (MPRO), Receptor-Binding Domain (RBD), RNA-dependent RNA polymerase
(RdRp), and Angiotensin Converting Enzyme 2 (ACE2) have been individually evaluated for their
docking and dynamics with graphene, so as to inactivate the virus. Details of interacting amino acid
residues of coronavirus with graphene is found in the study.

Conclusion:
Computationally, it is observed that most of these proteins were found interactive
through their amino acid residues with graphene. Number of interacting amino acid residues is considerable
enough to collectively acquire high binding energy. It can be envisaged that cumulative
perturbations of all the interactions of each protein caused by graphene can lower down or inactivate
the virus.
Reduced Serum Brain-Derived Neurotrophic Factor in Infants Affected by Severe Bronchiolitis
Authors: Nenna Raffaella , Petrella Carla , Bonci Enea , Papoff Paola , Jorgi Margherita di , Petrarca Laura , Conti Maria Giulia , Barbato Christian , Pietrangeli Alessandra , Fiore Marco , Midulla Fabio , Group BROME 
Published: April 2024

Background:
Bronchiolitis is an acute viral infection of the lower respiratory tract, typical
of infants in their first year of life and causing hypoxia in the most serious cases. Bronchiolitis recognizes various demographic risk factors that are associated with greater clinical severity; however, no
laboratory factors are yet able to correlate with the clinical severity. Neurotrophins as Brain-Derived
Neurotrophic Factor (BDNF) are mediators of neuronal plasticity. BDNF is constitutively expressed in
smooth muscle cells and epithelium of the lower respiratory tract, and as it is released during inflammatory conditions, serum levels may have a relevant role in the prognosis of infants with bronchiolitis.

Objective:
In the present pilot study, we aimed to disclose the presence of serum BDNF in infants
hospitalized with bronchiolitis at discharge as a disease severity indicator.

Methods and Results:
Serum BDNF, measured at hospital discharge, was significantly lower in severe
bronchiolitis (expressed as O2-supplemented infants). Furthermore, no changes were disclosed for the
Tropomyosin receptor kinase B, the main BDNF receptor and neurofilament light chain, a biomarker
of neuronal degeneration.

Conclusion:
Low serum BDNF in infants with severe bronchiolitis could be associated with a higher
utilization by lung cells or with an altered production by lung cells. Therefore, further research is required to study if a decreased production or increased consumption of this biomarker is at the base of
the above-mentioned findings.
Modern Trends in Digitalization of the Restaurant Business
Authors: Lyashkov A. V. , Anisimov A. Yu. 
Published: April 2024

The relevance of studying the issues of digitalization of the restaurant business is due to the need to search for strategic directions and key factors in the digital transformation of restaurant services, assessing modern consumer demands and global market development trends.The purpose of the work is to study the main trends in the digitalization of restaurant business organizations.The objectives of the study are to analyze promising areas of digitalization of the restaurant business, assess the market for online food delivery, self-service points and the use of digital technologies.Methodology. Methods of comparative and statistical analysis, induction and deduction were used as research methodsResults. It was revealed that the main directions of digitalization of the restaurant business are online orders and delivery of ready-made food, the development of self-service points, automation of the value chain, as well as the promotion of restaurant services using digital technologies. Despite the fact that automation of the restaurant business began before the COVID-19 pandemic, it served as a catalyst for the transition of restaurant services to the virtual space. However, the reactive approach of restaurant business organizations did not allow the formation of an effective strategy for the digital transformation of restaurant business organizations. The growth of digitalization of the industry is due to digital channels for promoting services that require significant investments, available only to large market players; for non-chain restaurants, this segment of the digital market is not yet available in full, which is a limiting factor in the development of the entire industry.Conclusions. The results obtained during the research allowed us to formulate theoretical and practical recommendations aimed at developing a strategic understanding of the planning processes and implementation of digital technologies in the activities of restaurant business organizations.
Strategic Priorities for the Development of Food Security of the State Taking into Account Hybrid Threats and Challenges
Authors: Krasnova V. V. , Dryndak A. A. 
Published: April 2024

Relevance. Food security is one of the most urgent and complex problems of the modern world. In the context of globalization, climate change, economic fluctuations and other factors, ensuring the stability and reliability of food security is becoming a complex task that requires effective strategies.The purpose is to analyze and evaluate strategic priorities in the field of food security, taking into account complex hybrid threats and challenges. Objectives: identification of strategic alternatives; development of a mathematical model with fuzzy variables and rules for evaluating strategic alternatives; analysis of evaluation results to identify the most effective strategic directions.Methodology. The research methodology included the use of fuzzy logic methods to build a mathematical model for evaluating strategic alternatives.Results. As a result of the study, it was revealed that the strategic alternative S1 received the highest rating, emphasizing its key importance for the sustainability of the food system. Alternatives S7, S9, S4 and S3 also have high ratings, which makes them potentially effective for ensuring food security. Alternatives S10, S8, S2, S6 and S5 are less of a priority, but are important for reducing various risks associated with food security, such as lack of food and vulnerability of supplies.Conclusions. The results of the study allowed us to conclude that the use of the fuzzy logic tool provides an opportunity to conduct a deeper and more comprehensive analysis of complex factors affecting food security. This approach allows us to take into account the uncertainty and multidimensionality of data related to the food system and introduce more accurate modeling of this dynamic area. Such a method enriches the decision-making process in the field of food security, contributing to the development of more effective strategic decisions and management approaches that take into account a variety of factors and their interaction. This contributes to improving the quality of research and helps to form more rational and informed strategies that contribute to ensuring the stability and reliability of food security.
Institutional Foundations for the Formation of a Resource-Innovative Model for the Development of the Economy of Russia and Its Regions
Authors: Kulikov M. V. 
Published: April 2024

Relevance.Global and tectonic shifts in the world economy that occurred in the XXI century in the world inevitably reflected on the state of national economies. The Russian economy, over a decade of economic sanctions against it, which are practically open-ended sabotage by the United States and a number of Western countries against the Russian critical infrastructure - the Nord Stream 2 gas pipeline on September 26, 2022, has found itself in a situation of de facto complete stoppage of export-import operations in the field of foreign trade with European countries.The purposeis to study the institutional foundations of the formation of a resource-innovative model of economic growth in the modern Russian economy. The objectives are interrelated and consist in the following: to analyze an array of economic scientific papers on the problem of research; to analyze the institutional foundations for the formation of a resource-innovative model of the development of the Russian economy; to determine the dynamics of budget financing of scientific research for the period from 2012 to 2022, etc. Methodology is a combination of general scientific research methods – analysis, synthesis of received information, interpretation of data. The information base of the study includes presidential decrees, strategic planning documents, national projects, scientific articles by Russian researchers on the problem under study. Results: the main problems of forming a resource-innovative model of economic growth in Russia at the present stage of economic development are identified; the shortcomings of the state policy in the field of financing R&D, innovative solutions and products that hinder the activities of innovative enterprises in the real sector of the economy are revealed.Conclusions.The Russian economy remains raw in its essential content. However, the introduction of digitalization technologies, artificial intelligence, new ideas and knowledge are gradually forming a resourceinnovative model for the development of the Russian economy.
Mortgage Lending in the Russian Federation
Authors: Obukhova A. S. , Biktagirova E. V. , Vladimirova A. R. 
Published: April 2024

Relevance. Today in Russia, more than half of the population feels the need to improve their housing. However, the opportunity to purchase housing without the help of borrowed funds is available only to a small group of citizens. Mortgage lending is the only way that allows you to purchase your own home and make it affordable for the population in Russia. The purpose of the study is to study the current state of mortgage lending in Russia, in particular, changes in average terms, interest rates on mortgages and leaders in the mortgage lending market.Objectives: to identify the role of mortgage lending in the Russian Federation; reflect the features of mortgage lending in Russia; analyze the mortgage lending market and its participants.Methodology. During the research process, general scientific methods were used: scientific abstraction, analysis and synthesis, generalization of scientific practice, deduction, induction.Results. The study shows that mortgage lending in Russia is actively developing. The availability of mortgages depends on the relationship between the level of income of the population and housing prices. The Russian market is now experiencing high real estate prices and, accordingly, high rates for this type of lending. All these factors hinder the development of the mortgage lending market, which is why the growth rate of mortgage lending has been declining in recent years.Conclusions. The increase in the volume of issued loans largely depends on the weighted average interest rate on mortgage loans. At the beginning of 2023, the weighted average rate on mortgage loans in Russia was 6.65% per annum, which was lower than at the beginning of the previous five years. In 2020, new types of preferential categories were introduced, which had a positive impact on the mortgage market as a whole. From an analysis of data on the issuance of mortgage loans in Russia over the past four years, it is clear that Sberbank and VTB are the leaders in mortgage lending in Russia, controlling most of the market.
Market Risk in Project Finance: Approaches to Review and Minimisation
Authors: Tikhomirov D. V. 
Published: April 2024

Relevance. Development of an investment project is commonly associated with many risks, and one of the most significant risks is a market risk i.e. is a possible failure to achieve prices, volumes and sales projected in total compared to those planned in the business plan and financial model of a project. Modern literature pays not enough attention to many relevant and practical issues of the market risk (i.e. is a possible failure to achieve prices, volumes and sales projected) review and reduction in the project finance and investment review, as well as to issues of work with independent marketing consultants, possible areas and ways for risk reduction and quality improvement.Purpose. The previous article considered approaches to understanding significance of the market risk and measures to deal with the risk in the review of price forecasts for an investment project. This article is supposed to consider the issues of risk reduction by organising optimal work with an independent consultant on these issues.Objectives. It is supposed to consider the possibility of engaging an independent marketing consultant, the requirements to the consultant by the financing organisation or investor, to provide an example of detailed scope of work for the independent analysis, give examples of comments to the marketing report and proposed measures to adjust the analysis in the report. It is also necessary to consider approaches to the use of the financial model in order to reduce market risk effects in project financing.Methodology. Methods of analysis and synthesis, induction and deduction as well as modelling are used in the article.Results. The article considers two major issues related to the accounting for or reduction of the market risks in the development of investment projects and providing project finance: the range of questions regarding working with a marketing consultant in order to decrease market risk effects is discussed, examples of requirements to the consultant and potential scope of work as well as some possible errors examples are given; author discusses instruments for considering these risks in financial model, including increased required levels for liquidity and debt service ratios in case of high risks and uncertainties.Conclusion. The market risk is one of the key risks in the development of an investment project and project review in project finance. A set of measures is needed to reduce and account for the risk. Proper application of these and other reasonable measures should enable project initiators and sponsors to ensure their successful development and compliance with the debt service schedule to third-party lenders.
Digitalization As a Modern Trend in the Management Contour of the Financial Sector
Authors: Tretyakova I. N. , Belousova L. S. , Svezhentseva K. I. 
Published: April 2024

Relevance. Digitalization of the financial sector is a process that changes traditional methods and models of work in the financial industry, introducing new technologies and digital innovations. This process covers various aspects of the financial sector, including banking, insurance, investments and other financial services. One of the main factors influencing the digitalization of the financial sector is the dynamically increasing pace of development of new information technologies. Digital technologies are aimed at redesigning the business processes of financial industry companies, improving the efficiency and accuracy of operations, as well as improving the quality of customer service and improving management effectiveness. The need to introduce and use digital technologies in the financial sector justifies the relevance and significance of this study. The purpose is to substantiate the role of information technology in the digital transformation of the financial sector.Objectives. The research work was carried out on the basis of interrelated tasks: to identify the most promising areas of fintech use in the company's activities, as well as to assess the current position of the financial sector among the branches of the Russian economy in the context of digital development.Methodology. The works of leading scientists on the subject under study serve as an information base. The applied general scientific methods such as the analysis and systematization of various sources of information on the topic, synthesis, comparison, analytical and graphical methods made it possible to achieve the set goal of the work.Results. Proves the comprehensiveness of the digital development of modern companies. The paper analyzes the use of digital technologies in the activities of modern companies, including companies in the financial sector, which allowed us to determine the current directions of development of functional elements of economic entities. The article describes the main problems faced by financial companies, as well as lists the prospects for the development of the financial sector in the context of digitalization.Conclusions. In the context of digitalization, information technologies act as a driver of effective and sustainable development of the financial sector.
Improving Technologies for Developing Personnel Solutions
Authors: Belyaeva T. A. , Kozieva I. A. 
Published: April 2024

Relevance. Modern socio-economic conditions actualize the improvement of technologies for developing personnel solutions as the basis for successful personnel management. An effective management decision acts as a resource for the development of the organization, personnel and each employee. The article explores the relationship between the concepts of personnel management, modern trends in personnel management and technologies for developing personnel solutions. The work examines the main HR trends and their impact on the technology of personnel decisions, analyzes the process of making personnel decisions in pearl organizations, and proposes the structuring of personnel decisions based on the results of diagnosing problem situations and recommended methods of decision-making.The purpose of the study is to identify directions for the development of technologies for developing personnel solutions in the personnel management system of a modern organization.Objectives: explore the relationship between modern concepts of personnel management, HR trends and technologies of personnel solutions; based on the diagnosis of problem situations in personnel management, structure management decisions and propose appropriate methods for their development, adoption and implementation; apply the method of analyzing hierarchies in the process of developing a personnel decision for the objective selection of a candidate for a vacant position to form the labor potential of an industrial enterprise.Methodology. During the research, general scientific methods of analysis and synthesis, the method of system analysis, expert assessment, the method of analyzing hierarchies.Results. Problematic situations in personnel management are diagnosed as the basis for structuring personnel decisions; in accordance with the results of diagnosis and structuring adequate decision-making methods are recommended. The method of hierarchy analysis is used as a method for effectively selecting alternatives in the conditions of selection, selection and hiring of engineering and technical personnel of an industrial enterprise.Conclusions. It is advisable to substantiate the directions for improving technologies for developing personnel solutions based on an assessment of the relationship with modern concepts and trends in personnel management, based on the results of a study of the characteristics of personnel management in various types of organizations, according to the structuring of problem situations in human resource management.
Digitalization from the Perspective of the Regional Community
Authors: Kilimova L. V. , Cherkashin M. D. , Tatarenkova D. Yu. , Pashutko D. S. 
Published: April 2024

Relevance. Currently, digitalization processes and the introduction of new technological innovations in Russian society lead to a restructuring of not only economic but also social relations, thereby predetermining both new opportunities and new risks. However, the degree of influence of these risks on individuals and society, their positive and negative effects in the scientific community have not yet been sufficiently formulated.The purpose is to identify the attitude of the regional population towards the digitalization of society and risk factors associated with the introduction of digital technologies into the life of society.Objectives: to analyze the manifestation of the digitalization process and its risks in the perception of the regional community; explore the degree of influence of digitalization risks on the life of society.Methodology. The study uses general scientific methods of cognition of social phenomena: structural-logical analysis and methods of theoretical generalization ‒ to clarify concepts and construct research conclusions; sociological methods for obtaining empirical data.Results. The population of the regional community has an understanding of the digital society, digitalization processes and various manifestations of risks in the digital society. Transformations in the digital sphere can bring catastrophically large-scale changes in society, and can transform not only the surrounding reality, but the person himself and the world around him.Conclusions. In modern digital society, the probabilistic manifestation of risks is not fully identified and their impact on the life of society is not assessed. Digitalization should be aimed at creating advantages (conveniences) in various aspects of everyday life and providing every citizen with equal opportunities to access services, information and knowledge provided on the basis of information and communication technologies.