bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do Men Care about Childcare? Women’s Relative Resources and Men’s Preferences for Work–Family Reconciliation Policies
Authors: Estévez-Abe Margarita , Lim Tae Hyun 
Published: February 2024

Abstract
Existing literature on the politics of work–family reconciliation policies focuses primarily on women and their policy preferences as the main driver of recent policy expansions. But what do we know about male preferences? This article explores this question in an innovative way by integrating insights from economic and sociological studies of division of labor and bargaining within the household. It investigates the link between women’s relative resources within the household and their male partners’ preferences for different types of reconciliation policies. Drawing on regression analysis of nineteen OECD countries using the International Social Survey Program data (Family and Changing Gender Roles IV), we find that: (1) men in dual-earner households, men in college-educated educational homogamy, and men in educational hypogamy (the woman is better educated) are more likely to support reconciliation policies; and (2) women’s earnings and education have different effects on men’s preferences.
Towards a more effective REACH legislation in protecting human health
Authors: Godderis Lode , De Ryck Evi , Baeyens Willy , Geerts Lieve , Jacobs Griet , Maesen Phillippe , Mertens Birgit , Schroyen Guy , Van Belleghem Frank , Vanoirbeek Jeroen , Van Larebeke Nicolas 
Published: February 2024

Abstract
There is growing evidence indicating the substantial contribution of man-made products to an increase in the risk of diseases of civilization. In this article, the Belgian Scientific Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) Committee gives a critical view on the working of REACH. The current regulatory framework needs to further evolve taking into account data generated using modern science and technology. There is a need for improved assessment process not only before but also after entering the market. Objectivity, transparency, and the follow-up after market access can be optimized. Additionally, no guidance documents exist for regulation of mixture effects. Further, the lengthiness before regulatory action is a big concern. Decision-making often takes several years leading to uncertainties for both producers and end users. A first proposed improvement is the implementation of independent toxicity testing, to assure objectivity, transparency, and check and improve compliance. A “no data, no market” principle could prevent access of hazardous chemicals to the market. Additionally, the introduction of novel testing could improve information on endpoints such as endocrine disrupting abilities, neurotoxicity, and immunotoxicity. An adapted regulatory framework that integrates data from different sources and comparing the outputs with estimates of exposure is required. Fast toxicology battery testing and toxicokinetic testing could improve speed of decision-making. Hereby, several improvements have been proposed that could improve the current REACH legislation.
XThe Seventeenth Century, Part II
Authors: Baker William , Stelzer Emily , Airey Jennifer , Parry David , Urban David V 
Published: February 2024

AbstractThis chapter has four sections: 1. General and Poetry; 2. Restoration Drama Excluding Dryden; 3. Dryden; 4. Prose. Section 1 is by William Baker, with Emily Stelzer covering Marvell and Herrick, and with William Baker and Emily Stelzer covering Crashaw; sections 2 and 3 are by Jennifer Airey; section 4 is by William Baker on Hobbes and Locke, David Parry on Bunyan, and David V. Urban on Pepys. There is no ‘Miscellaneous’ section this year.
Cervical Spine Stenosis Causing Diaphragmatic Paralysis: A Case Study and Narrative Review of Clinical Presentations and Outcomes
Authors: Lamb Colin D. , Schupper Alexander J. , Quinones Addison , Zhang Jack Y. , Steinberger Jeremy , Margetis Konstantinos 
Published: February 2024

Study Design:
Case report and narrative review.

Objective:
To explore the therapeutic role of surgical and nonsurgical treatment of diaphragmatic paralysis secondary to spinal cord and nerve root compression.

Summary of Background Data:
Phrenic nerve dysfunction due to central or neuroforaminal stenosis is a rare yet unappreciated etiology of diaphragmatic paralysis and chronic dyspnea. Surgical spine decompression, diaphragmatic pacing, and intensive physiotherapy are potential treatment options with varying degrees of evidence.

Methods:
The case of a 70-year-old male with progressive dyspnea, reduced hemi-diaphragmatic excursion, and C3-C7 stenosis, who underwent a microscopic foraminotomy is discussed. Literature review (MEDLINE, PubMed, Google Scholar) identified 19 similar reports and discussed alternative treatments and outcomes.

Results and Conclusions:
Phrenic nerve root decompression and improvement in neuromonitoring signals were observed intraoperatively. The patient’s postoperative course was uncomplicated, and after 15 months, he experienced significant symptomatic improvement and minor improvement in hemi-diaphragmatic paralysis and pulmonary function tests. All case reports of patients treated with spinal decompression showed symptomatic and/or functional improvement, while one of the 2 patients treated with physiotherapy showed improvement. More studies are needed to further describe the course and outcomes of these interventions, but early identification and spinal decompression can be an effective treatment.

OCEBM Level of Evidence:
Level—4.
Effect of phenylephrine rescue injection on hypotension after spinal anaesthesia for caesarean delivery when guided by both heart rate and SBP during an early warning window
Authors: Tang Wenxi , Liu Haiying , Zhang Zheng , Lyu Wenyuan , Wei Penghui , Zhou Haipeng , Zhou Jinfeng , Li Jianjun 
Published: February 2024

BACKGROUND
Spinal anaesthesia is now the most common technique for caesarean delivery. However, because of the intermittent nature of noninvasive blood pressure (NIBP) measurements, maternal blood pressure may become hypotensive between the measurements. There is thus an inbuilt delay before the anaesthesiologist can intervene to counteract the hypotension. Based on the principle that changes in blood pressure can induce compensatory changes in the heart rate (HR), combining the NIBP with real-time HR, we designed two warning windows to predict hypotension and hypertension.

OBJECTIVE
To evaluate whether phenylephrine administration guided by these warning windows would help maintain haemodynamic stability.

SETTING
A teaching hospital.

DESIGN
A randomised controlled trial.

PATIENTS
One hundred and ten pregnant women scheduled for elective caesarean delivery were enrolled, from which, after exclusions, 86 were eligible for the study.

INTERVENTIONS
All eligible patients received a continuous intravenous infusion of phenylephrine as soon as spinal anaesthesia was initiated. Thereafter, patients were randomly assigned to two groups. In the test group (Win-Group): rescue phenylephrine administration was triggered by an early warning window of HR above 100 beats per minute (bpm) and SBP 90 to 110 mmHg; pausing the infusion phenylephrine was triggered by a HR lower than 60 bpm and SBP greater than 90 mmHg. In the control group, phenylephrine was guided by BP only when it appeared on the monitor: SBP less than 90 mmHg was the trigger for administering rescue phenylephrine; SBP greater than 110 mmHg was the trigger for pausing the phenylephrine infusion.

MAIN OUTCOME MEASURES
The primary outcome was incidence of hypotension. Secondary outcomes were the incidence of hypertension and other adverse haemodynamic events.

RESULTS
The incidence of hypotension was significantly lower in the Win-Group than in the BP-Group (27.8 vs. 66.7%, P = 0.001). The minimum SBP was significantly higher in Win-Group than in BP-Group (93.9 ± 9.49 vs. 86.7 ± 11.16 mmHg, P
= 0.004). There was no significant difference in the incidence of hypertension between groups.

CONCLUSION
After spinal anaesthesia for caesarean delivery, when phenylephrine infusion is guided by HR along with BP from a warning window it effectively reduces the incidence of hypotension without any significant effect on incidence of hypertension.

TRIAL REGISTRATION
Chictr.org.cn; Identifier: ChiCTR 2100041812.
Transcriptome Analysis Reveals Enhancement of Cardiogenesis-Related Signaling Pathways by S-Nitroso-N-Pivaloyl-d-Penicillamine: Implications for Improved Diastolic Function and Cardiac Performance
Authors: Takenaka Yasuhiro , Hirasaki Masataka , Bono Hidemasa , Nakamura Shigeo , Kakinuma Yoshihiko 
Published: February 2024

Abstract:
We previously reported a novel compound called S-nitroso-N-pivaloyl-d-penicillamine (SNPiP), which was screened from a group of nitric oxide donor compounds with a basic chemical structure of S-nitroso-N-acetylpenicillamine, to activate the nonneuronal acetylcholine system. SNPiP-treated mice exhibited improved cardiac output and enhanced diastolic function, without an increase in heart rate. The nonneuronal acetylcholine–activating effects included increased resilience to ischemia, modulation of energy metabolism preference, and activation of angiogenesis. Here, we performed transcriptome analysis of SNPiP-treated mice ventricles to elucidate how SNPiP exerts beneficial effects on cardiac function. A time–course study (24 and 48 hours after SNPiP administration) revealed that SNPiP initially induced Wnt and cyclic guanosine monophosphate–protein kinase G signaling pathways, along with upregulation of genes involved in cardiac muscle tissue development and oxytocin signaling pathway. We also observed enrichment of glycolysis-related genes in response to SNPiP treatment, resulting in a metabolic shift from oxidative phosphorylation to glycolysis, which was suggested by reduced cardiac glucose contents while maintaining adenosine tri-phosphate levels. In addition, SNPiP significantly upregulated atrial natriuretic peptide and sarcolipin, which play crucial roles in calcium handling and cardiac performance. These findings suggest that SNPiP may have therapeutic potential based on the pleiotropic mechanisms elucidated in this study.
Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice
Authors: Wu Pau Yen , Caceres Ana Isabel , Chen Jiegen , Sokoloff Jamie , Huang Mingjian , Baht Gurpreet Singh , Nackley Andrea G. , Jordt Sven-Eric , Terrando Niccolò 
Published: February 2024

Abstract
Postoperative pain is a major clinical problem imposing a significant burden on patients and society. In a survey 2 years after orthopedic surgery, 57% of patients reported persisting postoperative pain. However, only limited progress has been made in the development of safe and effective therapies to prevent the onset and chronification of pain after orthopedic surgery. We established a tibial fracture mouse model that recapitulates clinically relevant orthopedic trauma surgery, which causes changes in neuropeptide levels in dorsal root ganglia and sustained neuroinflammation in the spinal cord. Here, we monitored extended pain behavior in this model, observing chronic bilateral hindpaw mechanical allodynia in both male and female C57BL/6J mice that persisted for >3 months after surgery. We also tested the analgesic effects of a novel, minimally invasive, bioelectronic approach to percutaneously stimulate the vagus nerve (termed percutaneous vagus nerve stimulation [pVNS]). Weekly pVNS treatment for 30 minutes at 10 Hz for 3 weeks after the surgery strongly reduced pain behaviors compared with untreated controls. Percutaneous vagus nerve stimulation also improved locomotor coordination and accelerated bone healing. In the dorsal root ganglia, vagal stimulation inhibited the activation of glial fibrillary acidic protein-positive satellite cells but without affecting microglial activation. Overall, these data provide novel evidence supportive of the use of pVNS to prevent postoperative pain and inform translational studies to test antinociceptive effects of bioelectronic medicine in the clinic.
Predicting Conversion to Insulin Sensitivity With Metformin
Authors: Gannon Jessica M. , Sanchez Marcos , Lines Katherine , Cairns Kathleen , Reardon Claire , Chengappa K.N. Roy , Calkin Cynthia V. 
Published: February 2024

Abstract

Background
Insulin resistance (IR) changes the trajectory of responsive bipolar disorder to a treatment-resistant course. A clinical trial conducted by our group demonstrated that IR reversal by metformin improved clinical and functional outcomes in treatment-resistant bipolar depression (TRBD). To aid clinicians identify which metformin-treated TRBD patients might reverse IR, and given strong external evidence for their association with IR, we developed a predictive tool using body mass index (BMI) and homeostatic model assessment–insulin resistance (HOMA-IR).

Methods
The predictive performance of baseline BMI and HOMA-IR was tested with a logistic regression model using known metrics: area under the receiver operating curve, sensitivity, and specificity. In view of the high benefit to low risk of metformin in reversing IR, high sensitivity was favored over specificity.

Results
In this BMI and HOMA-IR model for IR reversal, the area under the receiver operating curve is 0.79. At a cutoff probability of conversion of 0.17, the model's sensitivity is 91% (95% confidence interval [CI], 57%–99%), and the specificity is 56% (95% CI, 36%–73%). For each unit increase in BMI or HOMA-IR, there is a 15% (OR, 0.85; 95% CI, 0.71–0.99) or 43% (OR, 0.57; CI, 0.18–1.36) decrease in the odds of conversion, respectively.

Conclusions
In individuals with TRBD, this tool using BMI and HOMA-IR predicts IR reversal with metformin with high sensitivity. Furthermore, these data suggest early intervention with metformin at lower BMI, and HOMA-IR would likely reverse IR in TRBD.
Explaining racial and ethnic disparities in antiretroviral therapy adherence and viral suppression among U.S. men who have sex with men
Authors: Patel Deesha , Beer Linda , Yuan Xin , Tie Yunfeng , Baugher Amy R. , Jeffries William L. , Dailey Andre , Henny Kirk D. ,   for the Medical Monitoring Project
Published: February 2024

Objective:
To identify factors – including social determinants of health (SDOH) – that explain racial/ethnic disparities in antiretroviral therapy (ART) adherence and sustained viral suppression (SVS) among U.S. men who have sex with men (MSM) with HIV.

Design:
We used weighted data from 2017–2021 cycles of the Medical Monitoring Project.

Methods:
Among MSM taking ART, we calculated prevalence differences (PDs) with 95% confidence intervals (CIs) of ART adherence (100% ART adherence, past 30 days) and SVS (all viral loads in past 12 months <200 copies/ml or undetectable) for Black MSM (BMSM) and Hispanic/Latino MSM (HMSM) compared with White MSM (WMSM). Using forward stepwise selection, we calculated adjusted PDs with 95% CIs to examine if controlling for selected variables reduced PDs.

Results:
After adjusting for age, any unmet service need, federal poverty level (FPL), food insecurity, homelessness, time since HIV diagnosis, gap in health coverage, and education, the BMSM/WMSM PD for ART adherence reduced from −16.9 to −8.2 (51.5%). For SVS, the BMSM/WMSM PD reduced from −8.3 to −3.6 (56.6%) after adjusting for ART adherence, age, homelessness, food insecurity, gap in health coverage, FPL, any unmet service need, time since diagnosis, and ER visit(s). The HMSM/WMSM PD for ART adherence reduced from −9.3 to −2.9 (68.8%) after adjusting for age and FPL. The unadjusted HMSM/WMSM PD for SVS was not statistically significant.

Conclusions:
Adjusting for SDOH and other factors greatly reduced racial/ethnic disparities in ART adherence and SVS. Addressing these factors − particularly among BMSM − could substantially improve health equity among MSM with HIV.
Diversity in Plastic Surgery and the 2023 US Supreme Court Decision
Authors: Swanson Eric 
Published: February 2024

Abstract
The number of publications on the topic of diversity, equity, and inclusion in plastic surgery has increased exponentially in the last 5 years. Numerous changes have been implemented. On June 29, 2023, the US Supreme Court ruled that affirmative action in college admissions is unconstitutional. Writing for the majority, Justice Roberts concluded that eliminating racial discrimination means eliminating all of it, and the Equal Protection Clause applies without regard to any differences of race, of color, or of nationality. Justice Thomas authored a concurrence, stating that such policies are contrary to our colorblind constitution and our nation's equality ideal. Justice Sotomayor was joined by Justice Kagan and Justice Jackson in their dissenting opinion that ignoring race will not equalize a society that is racially unequal and that students of various racial backgrounds can offer different perspectives because of that identity. The reaction was largely partisan. Michelle Steel and Young Kim, Republican Asian American Congresswomen from California, lauded the decision, along with Republican Senator Tim Scott from South Carolina. Senate Majority Leader Democrat Chuck Schumer opined that the Supreme Court decision has put a “giant roadblock in our country's march toward racial justice.” Cory Booker, New Jersey Democrat, called the decision a devastating blow. President Joe Biden and former First Lady Michelle Obama also disagreed with the decision. Profound ramifications across our institutions of higher learning and in medical specialties are likely to follow. Legally, it will be difficult or impossible to defend race-based preferences going forward. This is true regardless of whether such policies were put in place with the best of intentions.
Rapidin situmutation detection in extracellular vesicle-DNA
Authors: Rahman Md. Mofizur , Wang Lixue , Rahman Md. Motiar , Chen Yundi , Zhang Wenlong , Wang Jing , Lee Luke P. , Wan Yuan 
Published: February 2024

ABSTRACTA PCR- and sequencing-free mutation detection assay facilitates cancer diagnosis and reduces over-reliance on specialized equipment. This benefit was highlighted during the pandemic when high demand for viral nucleic acid testing often sidelined mutation analysis. This shift led to substantial challenges for patients on targeted therapy in tracking mutations. Here, we report a 30-minute DNA mutation detection technique using Cas12a-loaded liposomes in a microplate reader, a fundamental laboratory tool. CRISPR-Cas12a complex and fluorescence-quenching (FQ) probes are introduced into tumor-derived extracellular vesicles (EV) through membrane fusion. When CRISPR-RNA hybridizes with the DNA target, activated Cas12a cantrans-cleave FQ probes, resulting in fluorescence signals for the quantification of DNA mutation. Future advancements in multiplex and high-throughput mutation detection using this assay will streamline self-diagnosis and treatment monitoring at home.
COVID-19 vaccine uptake and associated risk factors among first antenatal care attendees in Zambia, 2021-2022: a repeated cross-sectional study
Authors: Tembo Tannia , Somwe Paul , Bosomprah Samuel , Kalenga Kalubi , Moyo Nyembezi , Kabamba Bupe , Seffren Victoria , Fwoloshi Sombo , Rutagwera Marie-Reine , Musunse Maximillian , Mwiinga Linos , Gutman Julie R. , Hines Jonas Z. , Sikazwe Izukanji 
Published: February 2024

ABSTRACTIntroductionPregnant women are considered a high-risk group for COVID-19, and a priority for vaccination. Routine antenatal (ANC) care provides an opportunity to track trends and factors associated with vaccine uptake. We sought to evaluate COVID-19 vaccine uptake among pregnant women attending ANC in Zambia.MethodsWe conducted a repeated cross-sectional study in 39 public health facilities in four districts in Zambia from September 2021 to September 2022. Pregnant women who were aged 15-49 years were enrolled during their first ANC visit. Every month, ∼20 women per facility were interviewed during individual HIV testing and counseling. We estimated vaccine uptake as the proportion of eligible participants who self-reported having received the COVID-19 vaccine.ResultsA total of 9,203 pregnant women were screened, of which 9,111 (99%) were eligible and had vaccination status. Of the 9,111 included in the analysis, 1,818 (20%) had received the COVID-19 vaccine during the study period, with a trend of increasing coverage with time (0.5% in September 2020, 27% in September 2022). Conversely, 3,789 (42%) reported not being offered a COVID-19 vaccine. We found that older age, education, employment status, and prior COVID-19 infection were significantly associated with vaccine uptake.ConclusionCOVID-19 vaccine uptake among pregnant women was lower than estimates from the general population (27% across the four districts in September 2022), pointing to missed opportunities to protect this high-risk group. ANC visits were a viable point for conducting COVID-19 surveillance. Incorporating the vaccine as part of the routine ANC package might increase coverage in this group.Teaser key messageAntenatal care clinics could be an easy and sustainable platform for increasing COVID-19 vaccine uptake among pregnant women.Key FindingsDespite evidence that COVID-19 vaccines are safe in pregnancy, vaccine uptake was low among pregnant women in Zambia through the end of 2022.Various demographic characteristics were associated with the uptake of COVID-19 vaccines.Key ImplicationsIt is acceptable and feasible to assess COVID-19 vaccination uptake and hesitancy among pregnant women attending ANC. ANC may provide an easy, sustainable platform for routinely monitoring COVID-19 and other disease outbreaks.Key vaccination messages and mass vaccination strategies can be designed and adopted for pregnant women to reduce vaccine hesitancy and consequently, increase vaccine uptake.COVID-19 vaccination could be incorporated into routine antenatal care to help increase vaccination coverage among pregnant women seeking antenatal care services.
CRE mice exhibit hyperactive and impulsive behavior affecting their learning and retention performances
Authors: Desor Frédéric , El Hajj Aseel , Herzine Ameziane , Djelti Fathia , Bombail Vincent , Denis Isabelle , Oster Thierry , Malaplate Catherine , Lanhers Marie-Claire , Yen Frances T. , Claudepierre Thomas 
Published: February 2024

AbstractCRE recombinase is a protein that recognizes and mediates site-specific recombination between loxP site sequences. TheCre/loxPrecombination system has become a useful tool for genetic manipulation. Spatial regulation of recombination can be achieved by using cell type-specific promoters that drive expression of CRE in the tissue of interest. The temporal regulation can be obtained with CreER recombinase, which consists of Cre fused to mutated hormone-binding domain of the estrogen receptor (ER). In the more improved versions of the construct, the CRE-mediated gene regulation can be controlled both spatially and temporally, by combining tissue-specific expression of a CreER recombinase with its tamoxifen-dependent activity. We recently generated and characterized an astrocyte specific mutant of the lipolysis-stimulated lipoprotein receptorlsrgene by crossing Glast ERT2 mice with floxedlsrmice (El Hajj et al., 2022). During the behavioral analysis of generated mice, we identified specific hyperactive traits in the Glast ERT2 mice (CRE mice) that prevented them from being used as a control group. Here we further assessed the hyperactive trait of those CRE mice using a battery of behavioral tests. We showed that CRE mice exhibited hyperactive behavior combined with attention-deficit, sleep disturbance and impulsivity that affect their learning and memorization performances. These mice may therefore serve as a model to study attention deficit / hyperactivity disorder. Our work also pointed out the need for proper behavioral analysis of control groups in transgenic animal generation to avoid misinterpretation and misattribution of behavioral traits.