bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of First‐Trimester Combined Inflammatory Markers (NLR, SII, SIRI, and AISI) With Poor Obstetric Outcomes in Pregnancies With Ulcerative Colitis
Authors: Ozkavak Osman Onur , Tanacan Atakan , Serbetci Hakki , Karatas Esra , Haksever Murat , Basaran Ezgi , Atar Melike Busra , Sahin Dilek 
Published: February 2025

ABSTRACTAimTo compare the first‐trimester combined inflammatory markers between pregnant women diagnosed with ulcerative colitis (UC) and healthy pregnant women. Furthermore, to investigate the predictive value of these markers for adverse obstetric outcomes in pregnant women affected by UC.MethodsIn this retrospective study, data were collected from pregnant women with UC who gave birth at our hospital between January 2021 and May 2024 and from a control group of healthy pregnant women. A comparison was made between the two groups in terms of their demographic characteristics, neonatal outcomes, and the values of the first‐trimester neutrophil‐to‐lymphocyte ratio (NLR), systemic inflammation index (SII), systemic inflammatory response index (SIRI), and aggregated index of systemic inflammation (AISI). Furthermore, the relationship between these combined inflammatory markers and adverse obstetric outcomes in pregnant women with UC was investigated.ResultsNo notable discrepancy was observed between the UC group and the control group with respect to SIRI and AISI. The first‐trimester NLR and SII values were observed to be higher in the UC group in comparison to the control group. The data indicated that pregnant women with UC who experienced poor obstetric outcomes exhibited elevated levels of NLR, SII, SIRI, and AISI during the first trimester. In the ROC analysis, the predictive capacity of all four parameters for poor obstetric outcomes in UC patients was statistically significant.ConclusionThere is an association between elevated combined inflammatory markers in the first trimester and poor obstetric outcomes in pregnant women with UC.
The use of deidentified organ donor testes for research
Authors: Pryzhkova Marina V. , Skinner Marnie W. , Candelaria Juliana I. , Wellard Stephen R. , Jordan Philip W. 
Published: February 2025

AbstractOur knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis. Therefore, to specifically learn more about human testis development and function, there is a need to use human testis tissue for research. Human testicular tissues that have been donated for research have allowed extensive molecular and cytological assessments, as well as single‐cell transcriptome and epigenome analyses. These tissues have also been used for the development of cell technologies and in vitro models that aim to improve infertility treatments and diagnostics. Biopsied material taken from patients and designated for research is usually very small in size and is unsuitable for comprehensive studies. On the other hand, research using whole testes obtained from deceased, deidentified donors has become a valuable resource to assess conservation between humans and other organisms and identify human‐specific phenomena. This review discusses the acquisition of donated deidentified human testes and their use for basic science research.
Infants With a Congenital Diaphragmatic Hernia Had Favourable Pulmonary Hypertension Outcomes at 1 Year of Age
Authors: Dirickx Alice , Levy Marilyne , Mellul Kelly , Coignard Maxime , Khen‐Dunlop Naziha , Lapillonne Alexandre , Stirnemann Julien , Kermorvant‐Duchemin Elsa 
Published: February 2025

ABSTRACTAimPulmonary hypertension is frequent in neonates with a congenital diaphragmatic hernia, but long‐term data have been scarce. Our aim was to examine its prevalence, evolution and management and identify factors associated with its persistence.MethodsThis French retrospective cohort study compared the characteristics of neonates who had persistent pulmonary hypertension, or died with it, and those with normalised pulmonary pressures at 1 month and 1 year of age.ResultsMost (92%) of the 88 neonates we studied underwent surgery. Two‐thirds (67%) had preoperative pulmonary hypertension and they included 10 of the 11 who died after surgery. Pulmonary hypertension resolved after a median of 31 days in the 70 who were discharged alive and 27% required prolonged sildenafil treatment. At 1 year, 6 (9%) of the 65 children with echocardiographic data available still had elevated pulmonary pressures. Preoperative pulmonary hypertension, associated malformations and longer invasive ventilation were independently associated with persistent pulmonary hypertension at 1 month. Only prolonged invasive ventilation remained significant at 1 year.ConclusionDespite its high initial prevalence and impact on mortality, pulmonary hypertension resolved within weeks of surgery in the surviving neonates. The duration of invasive ventilation may have been a key factor in its persistence.
Silencing drug transporters in human primary muscle cells modulates atorvastatin pharmacokinetics: A pilot study
Authors: Hoste Emilia , Deldicque Louise , Muccioli Giulio G. , Panin Nadtha , Terrasi Romano , Paquot Adrien , Lingurski Maxime , Pyr dit Ruys Sébastien , Haufroid Vincent , Elens Laure 
Published: February 2025

Background and PurposeNon‐adherence to atorvastatin treatment is relatively common and partly due to statin‐related myotoxicities (SRMs). The risk of developing SRM is dose‐ and concentration‐dependent, highlighting the importance of atorvastatin pharmacokinetics. This study explored the inter‐individual variabilities in expression of the atorvastatin transporter gene contributing to modulation of atorvastatin within the muscle cell.Experimental ApproachmRNA levels of efflux and influx transporters were measured and modulated with siRNAs to evaluate effects on intracellular accumulation of atorvastatin in primary cultures of differentiated myotubes from 12 human volunteers.Key ResultsAll genes assessed were expressed with a high inter‐individual variability. In differentiated myotubes, efflux transporters were expressed at higher levels than the influx carriers. When considering efflux and influx transporters separately, ABCC1 and SLCO2B1 are the most highly expressed efflux and influx transporters. Suppression of ABCC1, ABCC4 and/or ABCG2 mRNA levels with siRNA significantly increased intracellular accumulation of atorvastatin in differentiated myotubes. Interestingly, the siRNA targeting ABCG2 had a moderate effect on intracellular accumulation of atorvastatin in a volunteer expressing the ABCG2 variant rs2231142 (c.421C>A, p.Gln141Lys). This hypothesis was further validated in a HEK recombinant model overexpressing ABCG2 either wild‐type (421C) or variant (421A). Reduction of SLCO1B1 and SLCO2B1 mRNA levels significantly modified intracellular accumulation of atorvastatin in only some volunteers, depending on the expression levels of transporters.Conclusion and ImplicationsSilencing ABCC1, ABCC4 or ABCG2 expression alters accumulation of atorvastatin in myotubes, whereas the effect of silencing influx transporters depends on the expression of these transporters.
Analyzing Oxygen Atom Distribution in FDA‐Approved Drugs to Enhance Drug Discovery Strategies
Authors: Masand Vijay H. , Patil Meghshyam K. , Al‐Hussain Sami A. , Samad Abdul , Rastija Vesna , Jawarkar Rahul D. , Masand Gaurav S. , Gawali Rakhi G. , Zaki Magdi E. A. 
Published: February 2025

ABSTRACTDespite advancements in molecular design rules and understanding biochemical processes, the field of drug design and discovery seeks to minimize the number and duration of synthesis‐testing cycles to convert lead compounds into drug candidates. A promising strategy involves gaining insightful understanding of key heteroatoms such as oxygen and nitrogen. This work presents a comprehensive analysis of oxygen atoms in approved drugs, aiming to streamline drug design and discovery efforts. The study examines the frequency, distribution, prevalence, and diversity of oxygen atoms in a dataset of 2049 small molecules approved by the FDA and other agencies. The analysis focuses on various types of oxygen atoms, including sp3, sp2‐hybridized, ring, and nonring. In general, existence of sp3‐O slightly outperforms sp2‐O, which is associated with balancing various factors such as flexibility, solubility, stability, and pharmacokinetics, in addition to activity and selectivity. In approved drugs, majority of oxygen atoms are present within 4 Å from the COM of the molecule. This analysis offers valuable understanding of oxygen distribution, which could be used during the multiparameter optimization process, facilitating the transformation of a hit/lead compound into a potential drug candidate.
Long‐Term Bone Height Changes After Sinus Floor Elevation With Maxillary or Mandibular Bone Grafts: A Radiological Study
Authors: Bouwman Wilhelmus F. , Eijsackers Francis A. , Bravenboer Nathalie , ten Bruggenkate Christiaan M. , Remmelzwaal Sharon , Schulten Engelbert A. J. M. 
Published: February 2025

ABSTRACTBackgroundThis retrospective study aimed to assess the impact of maxillary and mandibular autogenous bone grafts on maxillary bone height in patients who underwent maxillary sinus floor elevation (MSFE).MethodsThe study involved 92 patients, divided into two groups: 37 patients receiving maxillary bone grafts for MSFE and 55 patients receiving mandibular bone grafts for MSFE. Bone height after MSFE was measured on panoramic radiographs up to 60 months postoperatively, comparing different positions and situations.ResultsIn general, both maxillary and mandibular bone grafts resulted in an increase in bone height directly after the MSFE procedure, followed by a bone height loss over time, with no significant differences between the two groups for gap and free‐end positions. However, at distal to implant positions, mandibular bone grafts showed less bone loss. Despite gradual bone height loss, all implants remained covered with bone without exposure or subsequent loss, indicating a successful MSFE procedure.ConclusionThis radiologic study showed that over a long‐term period there is a similar bone height pattern at dental implant sites and sites distal to implants when maxillary or mandibular bone grafts are used in MSFE.
Identification of growth differentiation factor 15 as an early predictive biomarker for metabolic dysfunction‐associated steatohepatitis: A nested case–control study of UK Biobank proteomic data
Authors: Wang Hao , Xu Xiaoqian , Shi Lichen , Huang Cheng , Sun Yameng , You Hong , Jia Jidong , He You‐Wen , Kong Yuanyuan 
Published: February 2025

AbstractAimsThis study aims to determine the predictive capability for metabolic dysfunction‐associated steatohepatitis (MASH) long before its diagnosis by using six previously identified diagnostic biomarkers for metabolic dysfunction‐associated steatotic liver disease (MASLD) with proteomic data from the UK Biobank.Materials and MethodsA nested case–control study comprising a MASH group and three age‐ and sex‐matched control groups (metabolic dysfunction‐associated steatosis, viral hepatitis and normal liver controls) was conducted. Olink proteomics, anthropometric and biochemical data at baseline levels were obtained from the UK Biobank. The baseline levels of CDCP1, FABP4, FGF21, GDF15, IL‐6 and THBS2 were analysed prospectively to determine their predictive accuracy for subsequent diagnosis with a mean lag time of over 10 years.ResultsAt baseline, GDF15 demonstrated the best performance for predicting MASH occurrence at 5 and 10 years later, with AUCs of 0.90 at 5 years and 0.86 at 10 years. A predictive model based on four biomarkers (GDF15, FGF21, IL‐6 and THBS2) showed AUCs of 0.88 at both 5 and 10 years. Furthermore, a protein‐clinical model that included these four circulating protein biomarkers along with three clinical factors (BMI, ALT and TC) yielded AUCs of 0.92 at 5 years and 0.89 at 10 years.ConclusionsGDF15 at baseline levels outperformed other individual circulating protein biomarkers for the early prediction of MASH. Our data suggest that GDF15 and the GDF15‐based model may be used as easy‐to‐implement tools to identify patients with high risks of developing MASH at a mean lag time of over 10 years.
Is Australia ready for the rollout of amyloid‐targeting therapies for Alzheimer's disease? Results from a national survey characterising current infrastructure capability, workforce and training needs of memory and cognition clinics
Authors: Michaelian Johannes C. , Rowe Christopher C. , Kurrle Susan E. , Pond Constance Dimity , Woodward Michael , Naismith Sharon L. 
Published: February 2025

AbstractBackgroundNew amyloid‐targeting monoclonal antibody (mAb) therapies for Alzheimer's disease (AD) are currently under review by the Therapeutic Goods Administration for use in Australia.AimsTo determine the infrastructure, workforce and training needs of Australian memory and cognition clinics in order to characterise health system preparedness for these therapies.MethodsA national, cross‐sectional online survey of medical specialists.ResultsThirty medical specialists (geriatricians, n = 23; psychiatrists, n = 4; neurologists, n = 3) from 30 different clinics participated (public, 76.7%; private, 23.3%), including from metropolitan (73.3%), regional (20.0%) and rural (6.7%) areas. On average, clinics reported assessing 5.4 (SD = 3.2) new patients per week, of which 2.4 (range: 0–5) were considered to have mild cognitive impairment (MCI). Only 40% of clinics use biomarkers to assess whether patients with MCI have AD, and 45% have intravenous infusion capability. While the majority of clinicians were confident in their knowledge of mAbs, only 33% felt confident in using these. Identified impediments to clinical implementation included (i) lack of real‐world experience, (ii) lack of current Models of Care and appropriate use guidelines, (iii) current clinic set‐up and (iv) information about safety.ConclusionsAustralia's health system preparedness for amyloid‐targeting mAb therapies will require further investment in infrastructure, equity of access, clinician training and support. Long wait times already impact access to clinics, and with the forecast rise in MCI and dementia cases, services will need to be expanded, and appropriate Models of Care and clear and efficient inter‐sector health pathways will be needed to prepare for the use of mAbs.
Deciphering Property Crime Through OLS Regression: A Demographic Study
Authors: Masron Tarmiji , Ahmad Azizul , Abdillah Kiky Kirina , Ali Asykal Syakinah Mohd , Junaini Syahrul Nizam , Kimura Yoshinari 
Published: February 2025

ABSTRACTThis study explores the correlation between property crime and demographic factors in Kuala Lumpur and Putrajaya using spatial autocorrelation (SA) and ordinary least squares (OLS) regression from 2015 to 2020. The 2016 SA analysis shows a significant increase in Moran's I index (0.012905), with a positive z‐score of 2.020088 and a p value of 0.043374, indicating spatial clustering of crime. The study examines how factors like total population, household areas, residential areas, male populations and female populations influence number of property crime cases, revealing varying relationships year by year. By highlighting fluctuations in R‐squared and F‐statistic values, this research challenges static crime models, advocating for adaptable, data‐driven strategies in crime prevention. These findings emphasize the importance of continuous policy adjustments to address the evolving socio‐economic dynamics of urban areas.
Insight the essential role of manganese impurity to the initial hydration of Mn‐doped C4AF at the atomic level
Authors: Li Neng , Kang Yukun , Zhi Xiao , Ye Jiayuan , Jia Fujie , Chen Wei 
Published: February 2025

AbstractThe growing focus on reducing CO₂ emissions has promoted the use of alternative raw materials in cement production. Most heavy metal ions from these materials are preferentially incorporated into tetracalcium aluminoferrite (C₄AF), making it important to understand the effect of this incorporation on C₄AF hydration. In this work, we examined the hydration properties of manganese (Mn)‐doped C₄AF by combining well‐defined density functional theory (DFT) calculations and ab initio molecular dynamics (AIMD) simulations. The results indicate that Mn doping stabilizes the Mn–O octahedral structure, reducing charge transfer between water molecules and the surface. This change lowers adsorption energy and interfacial bond strength, weakening the potential for dissociative water adsorption. Mn doping reduces the initial hydration reaction rate of C₄AF, with the following hierarchy of reaction rates observed: pure C₄AF > Mn‐doped C₄AF surface > Mn‐doped C₄AF interphase. The hydrogen bonding density at the interface becomes localized upon Mn addition, reducing charge transfer between the water and the surface. Mn near the interface further delays the reaction by anchoring water molecules and hydroxyl groups. These findings provide valuable insights into the early hydration of Mn‐doped C₄AF.
Changes in Breastfeeding Relationships When Frontline Essential Working Mothers Return to Work During the COVID‐19 Pandemic: A Longitudinal Qualitative Online Study
Authors: Wood Natsuko K. , Helfrich‐Miller Kathleen R. 
Published: February 2025

ABSTRACTAimsMany frontline essential working mothers returned to work outside of the home after maternity leave during the COVID‐19 pandemic. The purpose of this study is to describe the changes in breastfeeding relationships.DesignA longitudinal descriptive qualitative design was used.MethodsFour open‐ended questions were asked to explore breastfeeding experiences at home, mothers' thoughts and feelings during direct breastfeeding, strategies to solve their breastfeeding problems, and workplace breastfeeding support. Data were collected by an online survey at 1, 3, 5 and 6 months between June 2022 and August 2023. Data were analysed using inductive content analysis from 21 mothers in the United States who were directly breastfeeding at least once a day for the first 6 months. The trustworthiness of study results involved coding by consensus, peer debriefing, and maintenance of an audit trial.ResultsThe core construct, “Changes in Breastfeeding Relationships When Frontline Essential Working Mothers Return to Work Outside of the Home” explained mothers' experience in four domains: (1) Breastfeeding changes, (2) Changes in sleep arrangements, (3) Social support to continue breastfeeding, and (4) Physical and emotional distress of mothers and infants.ConclusionUnrestricted direct breastfeeding upon reunion through the night along with co‐sleeping was the strategy mothers used to restore breastfeeding relationships with their infants and continue direct breastfeeding. Scheduled feeding and solitary sleep resulted in less direct breastfeeding, had negative consequences such as low milk supply, slow infant weight gain, and maternal distress.ImpactEven though frontline essential working mothers persevered with the complexities of their work during the COVID‐19 pandemic, findings highlight challenges mothers faced with their breastfeeding experience. Nurses need to discuss with mothers expected challenges of less frequent direct breastfeeding along with emotional tolls while being separated from their infant and strategies to develop sustainable breastfeeding relationships and continuation of direct breastfeeding.Patient or Public ContributionsNone.
Exploring the Floral Interactions of Diurnal Arctiid Moths Using Citizen Science
Authors: Beccacece Hernán Mario , Drewniak María Eugenia , Peralta Guadalupe , Cocucci Andrea Arístides , Sérsic Alicia 
Published: February 2025

ABSTRACTAn important number of floral visitors are insects, though interactions between moths, particularly arctiid moths (Lepidoptera: Erebidae: Arctiinae), and plants are underreported. Furthermore, although nocturnal moths visit flowers with shorter floral tubes, small apertures, landing platforms and mainly green colours, there is limited information on whether diurnal arctiid moths visit similar flowers. Therefore, we explored the mutualistic interactions between diurnal arctiid moths and flowers across different ecoregions in Argentina, using data collected from citizen science and social network platforms. Using image‐based records of diurnal arctiid moths feeding on flowers, we examined the floral traits and the geographical origin of plants most visited by the moths. A total of 529 interactions were recorded between 65 diurnal arctiid moth species and 136 plant species. Diurnal arctiid moths mainly visited native Asteraceae species, rotaceous floral architecture and white colour flowers. The ecoregion with the highest number of links between diurnal arctiid moth species and plant species was the Alto Paraná Atlantic forests, whereas the Humid Pampas had the highest number of total interactions. Overall, the flowers visited by diurnal arctiid moths had similar characteristics to those visited by both nocturnal moths and butterflies. Image‐based records from citizen science and social network platforms can be important data sources of mutualistic interactions, though their limitations in sampling efforts, such as across ecoregions, need to be considered.
The discount for lack of marketability term structure
Authors: Finnerty John D. 
Published: February 2025

AbstractI empirically estimate a discount for lack of marketability (DLOM) term structure for restriction periods up to 10 years. I model the multi‐year DLOM by annually compounding the 1‐year DLOM plus a term premium over the restriction period. I fit the model to a sample of 5,333 private equity placement implied DLOMs between 1985 and 2017. I estimate different DLOM term structures for the last and earlier pre‐initial public offering (IPO) private equity transactions. DLOM term structures exhibit level, slope, and curvature shifts similar to an interest rate term structure.
Language Ideologies of Racial Microaggression and Institutional Whiteness: Experiences of Chinese International Students in UK Higher Education
Authors: Gao Shuang 
Published: February 2025

ABSTRACTThis paper explores how language intersects with race in shaping the experience of Chinese international students in UK higher education (HE). Through the lenses of racial microaggression, critical race theory, and raciolinguistic ideologies, the study analyzes interviews and written diaries from Chinese students at a public research university. It reveals three language ideologies rooted in white supremacy: the ideology of English‐only, the ideology of incompetence, and the ideology of exclusion. These ideologies manifest in everyday interactions and institutional practices, positioning Chinese students as the inferior Other and reproducing the university as a white space. However, these ideologies are sometimes internalized by students who reproduce their own raciolinguistic inferiority. The article argues that students’ racial experiences are embedded in the racial logics of the internationalization of HE and the racial hierarchies of knowledge construction, which sustain and rely on white English supremacy as a multi‐scalar and transnational endeavor.