bluuebunny/crossref_metadata_2025_split huggingface dataset:
(289) Combined Therapy with Low-intensity Shockwave Therapy and Daily PDE5i Showed Better Pain Relieve and Sexual Function Improvement in Acute Phase of Peyronie Disease
Authors: Lu M , Huang Y 
Published: March 2024

Abstract

Introduction
To compare the efficacy and safety of daily use PDE5i and PDE5i combined with linear low-intensity shockwave therapy (Li-SWT) in the treatment of acute phase of Peyronie disease (PD).

Objective
68 patients with acute PD within 6 month onset were collected. The patients were 26–56 years old with an average of 42.3 years. The patients were randomly divided into two groups, 35 of which were orally administered with 5 mg of tadalafil every night for 3 months; the other 33 received 4 times of Li-SWT with daily PDE5i. Li-SWT uses the Renova shock wave therapy device with an energy density of 0.09mJ/mm2, each time 3200 times in the penile plaque, 900 times in the left and right penile shaft, and once a week for 4 consecutive treatments as a cycle. All patients underwent ultrasound or MRI, penile bending angle measurement, improvement of subjective symptoms, and IIEF-5 scale before and after treatment.

Methods
68 patients with acute PD within 6 month onset were collected. The patients were 26–56 years old with an average of 42.3 years. The patients were randomly divided into two groups, 35 of which were orally administered with 5 mg of tadalafil every night for 3 months; the other 33 received 4 times of Li-SWT with daily PDE5i. Li-SWT uses the Renova shock wave therapy device with an energy density of 0.09mJ/mm2, each time 3200 times in the penile plaque, 900 times in the left and right penile shaft, and once a week for 4 consecutive treatments as a cycle. All patients underwent ultrasound or MRI, penile bending angle measurement, improvement of subjective symptoms, and IIEF-5 scale before and after treatment.

Results
In the PDE5i group, the pain symptom relieve were improved in 80% patients (28 of 35 cases), while the combined group (PDE5i+Li-SWT) were improved in 90.9% patients (30 of 33 cases). The IIEF5 score in the PDE5i group improved from 13.8±7.9 to 19.5±8.1 and from 13.4±7.6 to 21.3±9.2 in the combined group, with both improvement between two groups. The plaque size were shrinkage 5 cases in PDE5i group and 12 cases in combined group, but penile curvature did not change significantly in both groups. In the PDE5i group, 5 patients had mild dizziness and back pain, while 3 patients had mild dizziness and back pain in combined group. There was no obvious adverse reaction observed for Li-SWT treatment.

Conclusions
Both the daily use PDE5i and the PDE5i combined with Li-SWT can improve the symptoms of acute PD patients, mainly to relieve pain and improve erectile function in some patients. The combined group had a better pain symptom relieve rate and more improvement for sexual function. The two methods can reduce PD plaque size in some cases, while both groups did not significantly change penile curvature. Both methods have good safety in the treatment of acute phase PD.

Disclosure
No.
A healthy lifestyle can support future sexual satisfaction: results from a 9-year longitudinal survey
Authors: Stenlund Säde , Sillanmäki Lauri , Koivumaa-Honkanen Heli , Rautava Päivi , Lagström Hanna , Suominen Sakari 
Published: March 2024

Abstract

Background
Previous follow-up studies have demonstrated the association between good health behavior and good sexual functioning for men, but the longitudinal relationship between multiple health behaviors and satisfaction with sex life remains understudied.

Aim
The aim of the study was to explore whether good health behavior associates with improved satisfaction with sex life for men and women in a follow-up of 9 years.

Methods
This cohort study utilized survey data from the population-based Health and Social Support study. It includes responses from 10 671 working-aged Finns. Using linear regression models, we examined a composite sum score representing 4 health behaviors (range, 0–4) in 2003 as a predictor of satisfaction with sex life in 2012. The analyses adjusted for various covariates in 2003, including satisfaction with sex life, living status, age, gender, education, number of diseases, and importance of sex life in 2012.

Outcomes
The outcome in the study was satisfaction with sex life in the year 2012.

Results
Participants who exhibited better health behavior at baseline demonstrated improved satisfaction with sex life when compared with those with poorer health behavior (β = −0.046, P = .009), even when controlling for the aforementioned covariates. The positive effect of reporting all beneficial health behaviors vs none of them was greater than having none vs 3 chronic conditions. Furthermore, this was almost half the effect of how satisfaction with sex life in 2003 predicted its level in 2012. These findings were supported by an analysis of the congruence of health behavior in the observation period from 2003 to 2012 predicting changes in satisfaction with sex life.

Clinical Implications
The results could serve as a motivator for a healthy lifestyle.

Strengths and Limitations
The current study used a longitudinal large sample and a consistent survey procedure, and it explored the personal experience of satisfaction instead of sexual function. However, the study is limited in representing today’s diversity of gender, since the options for gender at the time of survey were only male and female.

Conclusion
These findings indicate that engaging in healthy behaviors contributes to the maintenance and enhancement of satisfaction with sex life over time.
‘I think he will be able to adjust’. Letters of Recommendation Accompanying Jewish Refugees in Transit during National Socialism
Authors: Gerlach Lisa 
Published: March 2024

Abstract
Letters of recommendation are a specific subgenre of professional writing that both have their own history and shape the histories of the people they recommend. In the context of National Socialist persecution, recommendations typically accompanied well-educated German-Jewish refugees fleeing from Germany. Such letters can be seen as relics of an established support system, trying to enable and/or ease the period of internal transit into new and mostly unknown territories. Many Jews experienced a phase of internal transit as they adjusted to new demands and new social structures. This phase was usually a difficult one, as they not only had to adjust to a new country but also to process the events leading up to their forced migration, as well as navigating the psychological and often financial difficulties of organizing refuge. This article aims to show what kinds of information such letters of recommendation contained about transit. Focusing on the United States and on Palestine, the article challenges the understanding of these countries purely as ‘destination countries’, and shows how immigrants had to live through processes of internal transit. It also asks what content was the most useful to include in letters of recommendation—what kind of armour of good words was needed in transit—and how that content may have differed between the United States and Palestine.
Microscopic Focus on the Thyroid Follicles of the One-Humped Camel (Camelus dromedarius)
Authors: Roshdy Karam , Alsafy Mohamed A M , El-Gendy Samir A A , El-Mansi Ahmed A , Rezk Shaymaa 
Published: March 2024

Abstract
The microstructure of the thyroid gland of the one-humped camel (Camelus dromedarius) was described using morphometric, histological, immunohistochemical staining, and ultrastructural standard techniques. The follicular secretory units of the thyroid glands displayed comparable and variable sizes where the large follicles were situated at the peripheral margins; however, the small ones were located in the central region. Semisquamous epithelium (low cuboidal) lined the large thyroid follicles, while high cuboidal (columnar) epithelium lined the small ones. Our electron microscopic findings revealed that the low-sized cuboidal follicular cells lack organelles and are hypoactive. The high cuboidal follicular cells are active cells and rich in cellular organelles such as cisternae of rough endoplasmic reticulum, mitochondria, colloid droplets, scrolled Golgi apparatus, and secretory vesicles. A few degenerate follicular cells appeared on rare occasions. The parafollicular cells appeared with a more prominent and conspicuous nucleus than the follicular cells. The follicular cells were classified as active, inactive, or degenerated using transmission electron microscopy. The follicular and parafollicular cells showed calcitonin-positive immunoreactivity. Overall, the presented results showed particular convergences of the morphostructural aspects of the thyroid gland of C. dromedarius to that of other mammals with some distinctive features to cope with their physiology and harsh niche.
Primary and secondary prevention of stroke
Authors: Manning Lisa , Lam Man Yee , Robinson Thompson G. 
Published: March 2024

AbstractStroke is one of the leading causes of mortality, morbidity, and disability worldwide. Stroke and transient ischaemic attack survivors are at risk of recurrent stroke, which is often more severe and disabling. Despite the success in acute treatment and rehabilitation of stroke, prevention remains the most effective way to reduce the global burden of the disease. Since preventative strategies have early effectiveness, prompt recognition of symptoms, specialist assessment and diagnosis, and initiation of these secondary prevention strategies are of utmost importance in stroke prevention. This chapter provides an overview of current primary and secondary stroke prevention strategies, highlighting the importance of rapid recognition, urgent specialist care, and evidence-based interventions, which are the cornerstones of effective management.
“No Future to Be Had”: Journeying toward Death in Toni Morrison’s Song of Solomon
Authors: Kirton Jenny 
Published: March 2024

Abstract
This article examines Toni Morrison’s Song of Solomon (1977) by focusing on the way that the novel’s protagonist, Milkman Dead, rejects various traditional Euro-American formulations of “progress.” I argue that Milkman’s actions uncover a legacy of loss associated with African American culture and, relatedly, buried narratives of African American history. I take a cue from dance scholar Ann Cooper Albright’s attentiveness to what she terms “the cultural hegemony of the vertical” (37) in considering Milkman’s embodied resistance to existing paradigms of progress. By positing a vertical conceptualization of racial uplift ideology, the Dead family ancestry, and the journeys North and South between Michigan and Virginia in Song of Solomon, I demonstrate how Milkman’s very corporeality comes to signify the importance of African American cultural preservation and moving “counter-to” in re-visioning liberatory, counter-hegemonic routes of progress. My reading unfolds from a critical moment in chapter 2 of Song of Solomon; in this scene, the Dead family journeys northward in Milkman’s father’s Packard toward the wealthy white neighborhoods of Honoré, meanwhile Milkman demonstrates a remarkable preoccupation with what lies behind him. Situating Milkman’s embodied opposition to the journey’s progress as a point of departure, I examine how Morrison disrupts various paradigms of progress throughout Song of Solomon.
Indian Removal and the Plantation South: Cherokee Present-Absence in Three Neo-Slave Narratives
Authors: Harris Allison N 
Published: March 2024

AbstractThis article contends that we must understand a constitutive, interactive ontogenesis between modern Indigenous Americans and African Americans that is irreversibly shaped by the dominance of racialized slavery and the plantation economy. Building on the work of Gina Caison and Kevin Bruyneel, I argue that the present-absence of the Cherokee in prominent African American neo-slave narratives—Toni Morrison’s Beloved (1987), Edward P. Jones’s The Known World (2003), and Colson Whitehead’s The Underground Railroad (2016)—illustrates the imaginative function of Removal in the South. I slightly modify Bruyneel’s “absent/present dynamics” to show how the Cherokee persist as a constitutive Other used by these Black authors to expose the racial logic of the Plantationocene. I assert that the three novels imagine Black and Cherokee characters not where they are “supposed” to be in order to authorize Black fugitivity, demonstrating a triangulation of the power and racial formations of Blackness, whiteness, and Indigeneity in relation to the plantation.
Coupling of radiation and magnetospheric accretion flow in ULX pulsars: radiation pressure and photon escape time
Authors: Flexer Caitlyn , Mushtukov Alexander A 
Published: March 2024

ABSTRACT
The accretion flow within the magnetospheric radius of bright X-ray pulsars can form an optically thick envelope, concealing the central neutron star from the distant observer. Most photons are emitted at the surface of a neutron star and leave the system after multiple reflections by the accretion material covering the magnetosphere. Reflections cause momentum to be transferred between photons and the accretion flow, which contributes to the radiative force and should thus influence the dynamics of accretion. We employ Monte Carlo simulations and estimate the acceleration along magnetic field lines due to the radiative force as well as the radiation pressure across magnetic field lines. We demonstrate that the radiative acceleration can exceed gravitational acceleration along the field lines, and similarly, radiation pressure can exceed magnetic field pressure. Multiple reflections of X-ray photons back into the envelope tend to amplify both radiative force along the field lines and radiative pressure. We analyse the average photon escape time from the magnetosphere of a star and show that its absolute value is weakly dependent on the magnetic field strength of a star and roughly linearly dependent on the mass accretion rate being $\sim 0.1\, {\rm s}$ at $\dot{M}\sim 10^{20}\, {\rm g\, s^{-1}}$. At high mass accretion rates, the escape time can be longer than free-fall time from the inner disc radius.
Partisan Legal Traditions in the Age of Camden and Mansfield
Authors: Arvind T T , Burset Christian R 
Published: March 2024

Abstract
The 18th century is often treated by scholars as a period of juristic consensus. This article argues, in contrast, that the late 18th century saw the emergence of rival ‘Patriot’ and ‘Tory’ legal traditions. Through a detailed study of the jurisprudence of Lords Camden and Mansfield—who were both pillars of the law, as well as political and juristic rivals—we show that they differed systematically in their understanding of the common law, and that those differences had a partisan cast: although they were not crude attempts to instrumentalise law to political ends, their political and jurisprudential commitments influenced each other and emerged from the same intellectual roots. We place these differences in the context of the fragmentation of 18th-century Whig politics, and argue that they have important implications for how we understand and make use of the common law tradition in present-day scholarship.
Plasma ctDNA Monitoring of a PTCH1-Mutant Metastatic Adult Medulloblastoma Showing a Durable Benefit With Vismodegib
Authors: Cabezas-Camarero Santiago , García-Barberán Vanesa , Pérez-Alfayate Rebeca , Gómez del Pulgar María Elena , Cabrera-Martin Maria Nieves , Casado-Fariñas Isabel , Pérez-Segura Pedro 
Published: March 2024

Abstract
Adult medulloblastoma (MB) is a rare disease affecting 0.6 persons per million adults over 19 years of age. The SHH-activated/TP53-wild type is the most common subtype, accounting for 60% of adult MBs, being characterized by mutations in PTCH1, SMO, or the TERT promoter. Several small studies demonstrate objective but short-lived responses to SMO inhibitors such as vismodegib or sonidegib. Like other oncogene-addicted solid tumors, detection of the corresponding drivers through liquid biopsy could aid in the molecular diagnosis and monitoring of the disease through less invasive procedures. However, most studies have only evaluated cerebrospinal fluid as the ctDNA reservoir, and very limited evidence exists on the role of liquid biopsy in plasma in patients with primary central nervous system tumors, including MB. We present the case of a 26-year-old patient with a recurrent MB, in which next-generation sequencing (FoundationOne CDx) revealed a mutation in PTCH1, allowing the patient to be treated with vismodegib in second line, resulting in a durable benefit lasting for 1 year. Using an in-house digital PCR probe, the PTCH1 mutation could be tracked in ctDNA during treatment with first-line chemotherapy and while on treatment with vismodegib, demonstrating a precise correlation with the radiological and clinical behavior of the disease.
The Practice of Medical Dissection in Third-Century BCE Alexandria, Egypt as a Heterotopia of Deviation
Authors: Fowler Ryan C 
Published: March 2024

Summary
I argue that Foucault’s notion of heterotopia is a useful way to look at the practice of systematic human dissection performed in Alexandria, Egypt in the third century BCE. Foucault’s idea provides a novel way to consider why this practice—one not documented in any other time or place within Greek or Roman antiquity, and not officially recorded as a practice again until the 14th century CE with the work of de Liuzzi and da Vigevano—might have occurred when and where it did.
Actigraphic sleep dimensions and associations with academic functioning among adolescents
Authors: Mathew Gina Marie , Reichenberger David A , Master Lindsay , Buxton Orfeu M , Chang Anne-Marie , Hale Lauren 
Published: March 2024

Abstract

Study Objectives
There is mixed evidence regarding associations of sleep duration with academic functioning in adolescents and a lack of research on other sleep dimensions, particularly using objective sleep measures. We examined associations of multiple actigraphic sleep dimensions with academic functioning among adolescents.

Methods
Data were from the sleep sub-study of the age 15 wave of the Future of Families and Child Wellbeing Study (n = 774–782; 52% female), a national, diverse sample of teens. Adolescents wore wrist-actigraphs for ~1 week and completed a survey reporting academic performance and school-related behavioral problems. Regression models assessed whether average sleep duration, timing, maintenance efficiency, and SD-variability were associated with self-reported academic functioning in cross-sectional analyses adjusted for demographic characteristics, depressive symptoms, and anxious symptoms.

Results
Later sleep timing (hours) and greater sleep variability (SD-hours) were associated with poorer academic outcomes, including sleep onset variability with higher odds of receiving a D or lower (OR = 1.29), sleep onset (β = −.07), sleep offset (β = −.08), and sleep duration variability (β = −.08) with fewer A grades, sleep offset with lower GPA (β = −.07), sleep offset (OR = 1.11), sleep duration variability (OR = 1.31), and sleep onset variability (OR = 1.42) with higher odds of being suspended or expelled in the past 2 years, and sleep duration variability with greater trouble at school (β = .13). Sleep duration, sleep maintenance efficiency, and sleep regularity index were not associated with academic functioning.

Conclusions
Later sleep timing and greater sleep variability are risk factors for certain academic problems among adolescents. Promoting sufficient, regular sleep timing across the week may improve adolescent academic functioning.
Cost Analysis for Robotic and Open Gastrectomy
Authors: Hirata Yuki , Lyu Heather G. , Azimuddin Ahad M. , Lu Pamela , Ajith Jeeva , Schmeisser Jason A. , Ninan Elizabeth P. , Lee Kyung Hyun , Badgwell Brian D. , Mansfield Paul , Ikoma Naruhiko 
Published: March 2024

Objective:
To determine the magnitude of the perioperative costs associated with robotic gastrectomy (RG).

Background:
A robotic surgery platform has a high implementation cost and requires maintenance costs; however, whether the overall cost of RG, including all perioperative costs, is higher than conventional open gastrectomy (OG) remains unknown.

Methods:
Patients who underwent a major gastrectomy during February 2018 through December 2021 were retrospectively identified. We calculated the perioperative costs of RG and OG and compared them overall as well as in different phases, including intraoperative costs and 30-day postsurgery inpatient and outpatient costs. We investigated factors potentially associated with high cost and estimated the likelihood of RG to reduce overall cost under a Bayesian framework. All cost data were converted to ratios to the average cost of all operations performed at our center in year FY2021.

Results:
We identified 119 patients who underwent gastrectomy. The incidence of postoperative complications (Clavien-Dindo >IIIa; RG, 10% vs OG, 13%) did not significantly differ between approaches. The median length of stay was 3 days shorter for RG versus OG (4 vs 7 days, P < 0.001). Intraoperative cost ratios were significantly higher for RG (RG, 2.6 vs OG, 1.7; P < 0.001). However, postoperative hospitalization cost ratios were significantly lower for RG (RG, 2.8 vs OG, 3.9; P < 0.001). Total perioperative cost ratios were similar between groups (RG, 6.1 vs OG, 6.4; P = 0.534). The multiple Bayesian generalized linear analysis showed RG had 76.5% posterior probability of overall perioperative cost reduction (adjusted risk ratio of 0.95; 95% credible interval, 0.85–1.07).

Conclusions:
Despite increased intraoperative costs, total perioperative costs in the RG group were similar to those in the OG group because of reduced postoperative hospitalization costs.
Altered hormone expression induced genetic changes leads to breast cancer
Authors: Thakur Anchal , Rana Navya , Kumar Ranjit 
Published: March 2024

Purpose of review
Breast cancer ranks first among gynecological cancer in India. It is associated with urbanization, changes in lifestyle and obesity. Hormones also play a crucial role in the development of breast cancer. Steroid hormones play critical role in development of breast cancer.

Recent finding
Breast cancer is caused due to alteration in different hormone expressions leading to genetic instability. Loss or gains of functions due to genetic instability were associated with the alterations in housekeeping genes. Up-regulation in c-myc, signal transducer and activator of transcription (STAT), CREB-regulated transcription coactivator (CRTC), and eukaryotic translation initiation factor 4E (eIF4E) may cause the development of breast cancer. Peptide hormones are commonly following the phosphoinositide 3-kinases (PI3K) pathway for activation of cell cycle causing uncontrolled proliferation. Although steroid hormones are following the Ras/Raf/mitogen-activated protein kinase (MEK) pathway, their hyper-activation of these pathways causes extracellular-signal-regulated kinase (ERK) and MAPK activation, leading to carcinogenesis.

Summary
Alteration in cell cycle proteins, oncogenes, tumor suppressor genes, transcription and translation factors lead to breast cancer. Apoptosis plays a vital role in the elimination of abnormal cells but failure in any of these apoptotic pathways may cause tumorigenesis. Hence, a complex interplay of hormonal and genetic factors is required to maintain homeostasis in breast cells. Imbalance in homeostasis of these hormone and genes may lead to breast cancer.