bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic review of implant outcomes in treated periodontitis subjects
Authors: Ong Constantine T. T. , Ivanovski Saso , Needleman Ian G. , Retzepi Maria , Moles David R. , Tonetti Maurizio S. , Donos Nikolaos 
Published: April 2008

AbstractObjectives: To determine implant outcomes in partially dentate patients who have been treated for periodontitis compared with periodontally healthy patients.Material and Methods: All longitudinal studies (until March 2006) of endosseous dental implants of at least 6 months of loading were searched. Studies presented with one or more of the outcome measures (implant survival, success, bone‐level change, peri‐implantitis) were included. Screening, data abstraction and quality assessment were conducted independently and in duplicate.Results: From 4448 citations, 546 full‐text papers were screened and nine studies were included. Overall, the non‐periodontitis patients demonstrated better outcomes than treated periodontitis patients. However, the strength of evidence showed that the studies included were at a medium to high risk of bias, with lack of appropriate reporting and analysis of outcomes plus lack of accounting for confounders, especially smoking. Furthermore, the studies showed variability in the definitions of treated and non‐periodontitis, outcome criteria and quality of supportive periodontal therapy. Meta‐analysis could not be performed due to heterogeneity of the chief study characteristics.Conclusions: There is some evidence that patients treated for periodontitis may experience more implant loss and complications around implants than non‐periodontitis patients. Evidence is stronger for implant survival than implant success; methodological issues limit the potential to draw robust conclusions.
Periodontal parameters and cervical root resorption during orthodontic tooth movement
Authors: Giannopoulou Catherine , Dudic Alexander , Montet Xavier , Kiliaridis Stavros , Mombelli Andrea 
Published: April 2008

AbstractObjectives: To assess the relationship between periodontal parameters and cervical root resorption in orthodontically moved teeth.Material and Methods: In a standardized experimental tooth movement in 16 periodontally healthy subjects, 29 pre‐molars were tipped buccally for 8 weeks. Eighteen contralateral pre‐molars not subjected to orthodontic movement served as controls. Plaque Index (PI), Gingival Index (GI), probing depth and bleeding on probing were assessed three times before and six times during the experimental phase. Teeth were extracted and scanned in a micro‐computed tomography scanner. The presence or absence, and the severity of cervical root resorption were evaluated on the three‐dimensional reconstruction of the scans by two calibrated examiners.Results: Overall, periodontal parameters were not different between the test and the control teeth. Clear signs of buccal cervical resorption were detected on 27 of 29 orthodontically moved teeth and on one control tooth. Ten subjects had perfect oral hygiene and no gingivitis, whereas six subjects showed a moderate level of plaque and gingivitis (>20% occurrences of PI or GI with >0). No relationship could be demonstrated between resorption and periodontal parameters.Conclusions: Nearly all orthodontically moved teeth showed signs of cervical resorption. Periodontal parameters were unrelated to this important side effect of orthodontic treatment.
Interleukin‐11, interleukin‐1β, interleukin‐12 and the pathogenesis of inflammatory periodontal diseases
Authors: Yücel Özlem Özer , Berker Ezel , Gariboğlu Semra , Otlu Harika 
Published: April 2008

AbstractObjectives: The balance between pro‐inflammatory and anti‐inflammatory cytokines may be crucial for determining the immunopathology of gingivitis (G) and periodontitis. This study aimed to analyse interleukin‐1β (IL‐1β), IL‐11 and IL‐12 levels in gingival crevicular fluid (GCF) of patients with G and chronic periodontitis (CP).Material and Methods: Fourty subjects including 12 CP, 14 G and 14 controls (C) were enrolled. GCF samples were collected from six maxillary sites per patient and analysed for IL‐1β, IL‐11 and IL‐12 by an enzyme‐linked immunosorbent assay.Results: Significantly lower concentrations of IL‐11 were detected in CP compared with both G and C groups (p<0.05). The CP group had a significantly higher total amount of IL‐12 and IL‐1β compared with the C group (p<0.05). The IL‐11:IL‐1β cytokine ratio was higher in both G and C groups compared with the CP group. The IL‐11:IL‐1β ratio became progressively lower with increasing probing depth (p<0.01).Conclusions: Our data showed that IL‐11 levels are significantly decreased in GCF from sites with periodontitis compared with G and healthy sites. Because of the possible preventive effect of IL‐11 on inflammation, IL‐11 may be an important factor in the therapeutic modulation of periodontal disease.
Trends over 30 years, 1973–2003, in the prevalence and severity of periodontal disease
Authors: Hugoson Anders , Sjödin Bengt , Norderyd Ola 
Published: April 2008

AbstractAim: The present investigation presents findings of the prevalence and distribution of gingivitis and periodontitis in a Swedish population over the 30 years 1973–2003.Material and Methods: Four cross‐sectional epidemiological studies in 1973, 1983, 1993, and 2003 were performed in Jönköping, Sweden. Random samples of individuals aged 20, 30, 40, 50, 60, 70, and 80 years were examined clinically and radiographically. Diagnostic criteria were edentulousness, number of teeth, plaque, gingival status, probing pocket depth, gingival recession, alveolar bone level, and classification according to periodontal disease status.Results: In all age groups, the number of edentulous individuals decreased dramatically and the number of teeth increased. Oral hygiene improved considerably. Over the 30 years, the proportion of periodontally healthy individuals increased from 8% in 1973 to 44% in 2003 and the proportion of individuals with gingivitis and moderate periodontitis decreased. There was a non‐significant trend for the proportion of individuals with severe periodontal disease experience (Group 4) to decrease, while the proportion of individuals with advanced periodontitis (Group 5) remained unchanged.Conclusion: Oral hygiene and periodontal health improved significantly in the 20–80‐year age groups over the 30 years 1973–2003.
Severe periodontitis in young adults is associated with sub‐clinical atherosclerosis
Authors: Cairo Francesco , Castellani Sergio , Gori Anna Maria , Nieri Michele , Baldelli Giorgia , Abbate Rosanna , Pini‐Prato Giovan Paolo 
Published: April 2008

AbstractAim: The aim of this study was to evaluate the association between severe periodontitis and sub‐clinical atherosclerosis in young (40 years) systemically healthy individuals.Material and Methods: Ninety systemically healthy subjects, 45 affected by severe periodontitis (mean age 36.35±3.65 years) and 45 controls without a history of periodontal disease (mean age 33.78±3.28 years), were enrolled in this study. Patients and controls were paired for age, gender, body mass index and smoking habits. Carotid intima‐media thickness (IMT) was bilaterally assessed by ultrasonography at the level of common carotid artery. Traditional cardiovascular risk factors for atherosclerosis were also evaluated.Results: The overall mean carotid IMT was 0.82±0.13 mm in the test group and 0.72±0.07 mm in the control group ( p<0.0001). Stepwise regression analysis showed that periodontitis ( p<0.0001) and regular physical activity ( p=0.0009) were predictor variables of overall mean carotid IMT. When considering an IMT0.82 mm as the critical index of increased cardiovascular risk, periodontal patients overcame this threshold compared with healthy patients by an odds ratio=8.55 [confidence interval 95%: 2.38; 39.81]. No investigated haemostatic variable was associated with increased carotid IMT.Conclusion: Severe periodontitis is associated with sub‐clinical atherosclerosis in young systemically healthy patients.
Association of unipolar depression with gene polymorphisms in the serotonergic pathways in Han Chinese
Authors: Shi Mei , Hu Jian , Dong Xuesong , Gao Yue , An Ganghui , Liu Wei , Chen Li , Sun Xueying 
Published: April 2008

Objective:The present study aims to investigate the association of unipolar depression (UPD) with six serotonergic gene polymorphisms in Han Chinese.Methods:One hundred and thirty-two UPD patients and 180 healthy controls were genotyped for polymorphisms of six serotonergic genes, including tryptophan hydroxylase (TPH1 A218C), serotonin transporter promoter region (5-HTTLPR), serotonin receptor 2A (5-HT2AR −1438G/A), serotonin receptor 2C (5-HT2CR Cys23Ser), serotonin receptor 6 (5-HT6R C267T) and serotonin receptor 1Dβ (5-HT1DβR T371G). Symptomatic clusters were evaluated by the 24-item Hamilton Rating Scale for Depression (HAMD).Results:The frequencies of S/S genotype and S allele in 5-HTTLPR polymorphism were significantly higher in UPD patients than in healthy controls. There was a significant difference in distributions of genotypes in 5-HT2CR Cys23Ser polymorphism between UPD patients and control subjects, but the difference became no significant when the data were further stratified by gender. The patients with genotypes G/G and T/G of 5-HT1DβR T371G polymorphism had significantly lower scores of diurnal variation evaluated by HAMD than those with genotype T/T, while the patients with genotype T/G had significantly higher scores of hopelessness than those with genotypes G/G and T/T. There were no significant differences in genotypic and allelic distributions of TPH1 A218C, 5-HT2AR −1438G/A or 5-HT6R C267T polymorphisms between the case and control groups.Conclusion:The study demonstrates that 5-HTTLPR and 5-HT2CR Cys23Ser polymorphisms might contribute to susceptibility of UPD, and the genotype T/T in 5-HT1DβR T371G polymorphism might be a risk factor for diurnal variation, while T/G might be a protective factor against hopelessness in Han Chinese populations.
Does climate change affect the incidence of skin and allergic diseases in Germany?
Authors: Augustin Jobst , Franzke Nadine , Augustin Matthias , Kappas Martin 
Published: April 2008

Summary  Background: Skin diseases have great socio‐economic importance in Germany due to their high and in some cases still‐increasing prevalence. Little attention has yet been paid to the influence of the change in climate on these diseases. Objective: Clarify the evidence of the effects of climate change on the prevalence of skin diseases and allergies in Germany. Methods: First, a theoretical model of the possible mechanisms and influence factors of climate and weather was created for different disease groups (skin malignancies, allergies, skin infections). Then, a systematic online and manual literature search was made for model‐derived key words.The relevant publications were selected and evaluated according to a priori criteria. Results: From a total of n = 31,221 hits, n = 320 publications remained for evaluation.Changes in the following parameters can be regarded as essential climatologic factors influencing the prevalence of skin and allergic diseases: temperature, UV radiation, precipitation/humidity, cloudiness, and general weather conditions.There were only a few original articles addressed to this topic. Most of them address recurring phenomena (especially levels of airborne pollen), UV radiation or ozone (and the ozone hole). Quantitative statements, prognosis models and climate scenarios have not yet been published for Germany with respect to skin diseases. Conclusion: Only few scientific articles on the relationship between climate changes and the prevalence of skin diseases have been published. They do not allow a reliable statement on future developments. The outlook for changes in prevalence requires further clarification using published climate models.
E‐learning in the dermatological education at the Charité: evaluation of the last three years
Authors: Lüdert Tilman , Nast Alexander , Zielke Hendrik , Sterry Wolfram , Rzany Berthold 
Published: April 2008

Summary  Background: Numerous e‐learning initiatives have been launched during the last decade. Many of them have not been continued, due to lack of acceptance on the part of the students, low quality or insufficient financial funding. Since 2002, the DEJAVU project has been integrated into the curriculum at the Department of Dermatology at Charité‐Universitätsmedizin Berlin. DEJAVU offers an online archive of recorded lectures, lecture hand outs, structured learning modules, and case reports as well as online information about the courses/classes. Methods: Since beginning of the summer semester 2005, the student's acceptance and utilization of the online offerings was regularly surveyed, using anonymous questionnaires handed out together with the final exams. The teaching staff's opinions about e‐learning were surveyed by means of a single anonymous questionnaire. Results: At the end of winter semester 2006/2007,93.5% of the students were aware of the existence of the e‐learning program. The average amount of time spent with the program was 14.7 hours over the course of one semester. 66.8% of the students considered the program as very useful for their dermatology training. The lecture notes were the most frequently used online resource. Among the teaching staff, 86% considered e‐learning a useful addition to traditional teaching. Conclusions: Our results show that e‐learning is very well accepted by our students. It offers an additional way of acquiring knowledge and should be used to complement traditional ways of teaching.
Inhibition of Seminal Emission Is the Main Cause of Anejaculation Induced by a New Highly Selective α1A-Blocker in Normal Volunteers
Authors: Kobayashi Ko , Masumori Naoya , Hisasue Shin-ichi , Kato Ryuichi , Hashimoto Kohei , Itoh Naoki , Tsukamoto Taiji 
Published: April 2008

ABSTRACT

Introduction
Recent studies have highlighted the influence of α1-adrenoceptor antagonists on ejaculatory function.

Aim
We evaluated the effect of a new, highly selective α1A-blocker, silodosin, on ejaculatory function of normal volunteers.

Methods
The study included 15 healthy male urologists who voluntarily participated in the study. They took 4 mg of silodosin or a placebo twice daily for 3 days in a randomized, double-blind crossover design.

Main Outcome Measures
We investigated the ejaculatory volume, sperm count in urine after ejaculation, and fructose concentration in seminal plasma before and after administration of the agents.

Results
All volunteers on silodosin had a complete lack of ejaculation. Three days after completion of silodosin, the mean ejaculatory volume recovered to the baseline level. There was no sperm in urine after ejaculation under silodosin administration in any volunteer.

Conclusions
All volunteers on silodosin had anejaculation and did not show post-ejaculate sperm in their urine. The mechanism of ejaculatory dysfunction caused by silodosin is a loss of seminal emission.
Different Testosterone Levels Are Associated with Ejaculatory Dysfunction
Authors: Corona Giovanni , Jannini Emmanuele A. , Mannucci Edoardo , Fisher Alessandra D. , Lotti Francesco , Petrone Luisa , Balercia Giancarlo , Bandini Elisa , Chiarini Valerio , Forti Gianni , Maggi Mario 
Published: April 2008

ABSTRACT

Introduction
The role of testosterone (T) in pathogenesis of ejaculatory symptoms has not been completely clarified.

Aim
To evaluate the possible contribution of T and hypogonadism in the control of the ejaculatory reflex, comparing subjects with premature ejaculation (PE) or delayed ejaculation (DE) to those without ejaculatory dysfunction.

Methods
A consecutive series of 2,437 (mean age 51.9 ± 13.0 years) male patients with sexual dysfunction was studied.

Main Outcome Measure
Several hormonal and biochemical parameters were studied, along with the structured interview on erectile dysfunction (SIEDY) structured interview. Hypogonadism were defined when total testosterone (TT) was lower than 10.4 nmol/L.

Results
Among the patients studied, 714 (25.9%) and 121 (4.4%) reported PE and DE, respectively. In the youngest age band (25–40 years), subjects with PE reported higher TT and free testosterone (FT) levels when compared to the other groups (subjects with DE or those without PE and DE; P &lt; 0.05 for both). Conversely, in the oldest age band (55–70 years), lower TT and FT levels were observed in DE subjects. Accordingly, patients with PE showed the lowest (12%) and subjects with DE the highest (26%) prevalence of hypogonadism. These differences were confirmed even after adjustment for confounders such as age and libido (HR = 0.75 [0.57–0.99] and 1.83 [1.14–3.94] for PE and DE, respectively; both P &lt; 0.05).

Conclusion
Our data seem to suggest that T plays a facilitatory role in the control of ejaculatory reflex. Both central and peripheral mechanisms have been advocated to explain this association. Clinical studies are currently in progress to further establish the role of T in the ejaculatory dysfunction, attempting to revert DE by androgen administration.
Spatial and Temporal Patterns of Pharmaceuticals in the Aquatic Environment: A Review
Authors: Stamm C. , Alder A. C. , Fenner K. , Hollender J. , Krauss M. , McArdell C. S. , Ort C. , Schneider M. K. 
Published: April 2008

AbstractIn recent years, human and veterinary pharmaceuticals have received much attention as pollutants of water bodies or drinking water resources due to possible negative effects on humans or the ecosystem even at very low concentrations. Over the last 10 years, considerable progress has been made regarding the knowledge of the exposure of water bodies to those drugs. This review summarizes the present understanding in this broad and interdisciplinary field incorporating contributions ranging from trace analytics to spatially distributed modelling of point‐source and diffuse pollution. It discusses the main factors and processes controlling the environmental fate of pharmaceuticals from their usage to their spatial and temporal occurrence in water bodies. The current research is still rather phenomenological and further advancement of the field requires more integrated, quantitative mass flux analyses. Such analyses should also consider the explicit incorporation of uncertainties that appropriately reflect the current limited understanding and data availability.
Stretching the Effectiveness of Analogical Training in Negotiations: Teaching Diverse Principles for Creating Value
Authors: Moran Simone , Bereby‐Meyer Yoella , Bazerman Max 
Published: April 2008

AbstractThe present research adapts analogical training to teach negotiators broad concepts of creating value. Recent research has shown specific analogical training, wherein negotiators draw analogies between different cases involving the same strategy, to be effective for learning and transferring specific value‐creating strategies. The current results endorse the approach that analogical training can be a valuable tool for teaching negotiation, but argue that it can be enhanced by considering the breadth of the negotiation concepts that are learned. Diverse analogical training, wherein negotiators compare several different value‐creating strategies, was shown to be more effective for learning broad underlying value‐creating principles. This method facilitated transfer to a distinctive task and improved performance on a variety of value‐creating strategies, including some that were not previously trained. The improved performance was also accompanied by enhanced understanding of the potential to create value.
Emergent Negotiations: Stability and Shifts in Negotiation Dynamics
Authors: Olekalns Mara , Weingart Laurie R. 
Published: April 2008

AbstractNegotiation is a dynamic process in which negotiators change their strategies in response to each other. We believe mutual adaptation is best conceptualized as an emergent process and is a critical determinant of negotiators’ abilities to identify mutually beneficial solutions. We argue that three factors drive the process of negotiation and influence the quality of agreements: alignment of negotiators’ strategies across individuals (strategy sequences), alignment of negotiators’ strategies with the negotiation‐wide dynamic (phases), and congruence of negotiators’ goals.
Prompt Assessment of WST11‐VTP Outcome Using Luciferase Transfected Tumors Enables Second Treatment and Increase in Overall Therapeutic Rate
Authors: Fleshker Shimrit , Preise Dina , Kalchenko Vyacheslav , Scherz Avigdor , Salomon Yoram 
Published: April 2008

AbstractThis study hypothesized that success rate assessment of vascular targeted photodynamic therapy (VTP) of solid tumors 24 h post‐treatment may allow prompt administration of a second treatment in case of failure, increasing the overall success rate. Here, we show that treatment of luciferase transfected CT26‐luc mouse colon carcinoma tumors in BALB/c mice by VTP with WST11 (a Pd‐bacteriochlorophyll‐based photosensitizer) allows fast assessment of treatment success 24 h post‐treatment, using bioluminescence imaging (BLI). WST11‐VTP was found to abolish luciferin bioluminescence in the treated tumors resulting in two types of responses. One, comprising 75% of the mice, signified successful outcome, presenting neither BLI signal nor tumor regrowth (24 h–90 days post‐VTP). The second (the remaining 25% of the mice) signified treatment failure, presenting various levels of BLI signal with subsequent tumor regrowth (24 h–90 days). Consequently, the mice that failed the first treatment were treated again. We show that treatment success rate in both VTP sessions was identical and that the cumulative success rate of the treatment increased from 75% to over 90%. These results therefore, present a fast method of assessing VTP outcome and support the feasibility of successive multiple treatments with these sensitizers in the clinical arena. The presented methodology can also be helpful in future preclinical studies, and expedite the development of VTP drugs.