bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating inflammatory cytokines and risk of bladder cancer: a Mendelian randomization study
Authors: Li Changjiu , Chen Jun , Shang Kun , Li Ning , Qi Yaqin , Chen Chao , He Huadong 
Published: March 2024

Abstract
Background: Epidemiological evidence has verified the relationship between inflammatory biomarkers and bladder cancer (BCa). It is uncertain whether these associations are causal. Here, we performed Mendelian randomization (MR) analyses to systematically evaluate the causal relationship between the wide panel of inflammatory cytokines and BCa risk.
Methods: The Exposure data were extracted from the genome-wide association study (GWAS) of 47 circulating cytokines. The cis-protein quantitative trait locus (cis-pQTL) and cis-expression quantitative trait locus (cis-eQTL) were used as instrumental variables. The outcome data were obtained from the United Kingdom Biobank. Two-sample MR analyses were performed to assess the causal inference of inflammatory cytokines on BCa risk, followed by sensitivity analyses to overcome the disadvantages of inverse-variance weighted method.
Results: We observed Eotaxin has significant causal effects on BCa (cis-pQTL: OR= 0.997, 95% CI =0.995-0.999, p=0.002; cis-eQTL: OR= 0.996, 95% CI =0.993-0.998, p =0.001) in both the cis-pQTL and cis-eQTL definition. Further single-cell analysis revealed Eotaxin was predominantly expressed in inflammatory-cancer-associated fibroblasts (iCAFs) but not in myo-cancer-associated fibroblasts (mCAFs). Besides, CCL11 expression was significantly higher in normal tissue iCAFs than in BCa iCAFs.
Conclusions:Our study provides supportive evidence on the role of specific cytokines in cancer aetiology. CCL11+ iCAFs may be a subtype of iCAFs that inhibit tumor progression. Further studies are needed to investigate the potential mechanisms of cytokines as drug targets for cancer prevention.
Moisture-induced timber joining - Utilizing the hygroscopicity and shape-memory effect of wood resulting in dimensional change in a prefabricated wood-only, self-built, sawn timber system for affordable housing in Colombia
Authors: Salzberger Max , Rojas Juan Sebastian Cruz , Koskamp Gilbert 
Published: March 2024

Abstract
From a global perspective, the building industry stands as a significant factor of environmental impact on the planet. Wood has emerged as a promising construction material as a sustainable building source, gaining traction in the industry due to its carbon storage capabilities and prefabricated possibilities [13]. Particularly in the context of rural Colombia, the integration of prefabricated timber constructions, coupled with advancements in digital fabrication technologies, holds the promise of facilitating social reconstruction. Furthermore, such an approach poses the potential to enhance material performance and contribute positively to its end of life [1]. Nevertheless, existing research identifies a critical gap within the wood-to-wood timber connections to tackle better design, manufacture, assembly, and deconstruction (DfMA + D) [20]. Consequently, this study endeavours to explore the application of Computer Numerical Control (CNC) technologies in conjunction with the material's response to changes in relative humidity. The aim is to devise a mechanism for tight-fitting structural wood connections, the central focus of this research lies in understanding the collaborative interaction between sawn timber and moisture fluctuations. By doing so, the study seeks to introduce a new construction methodology and building system centred around material climate reaction and its expansion capacity applications in traditional connections, thereby mitigating the need for chemical and mechanical structural joints, ultimately resulting in a self-assembly system destined to low-income populations in the Colombian territory. This study proves the enhancement of timber connection to tensile stress up to 50% of its original capacity by implementing the moisture induced process and developing a building system utilising this joining method for the assembly of elements for housing in Colombia.
Streamlining College Cafeteria Operations: A Web Portal for Efficient Bulk Order Management
Authors: John Christine John , Eluvathingal Tacita , Khan Aafreen , Albert Serena , Ojha Mritunjay 
Published: March 2024

Abstract
Efficient management of bulk orders in college cafeterias is paramount for ensuring timely service and customer satisfaction. In this paper, we address the challenge of manual and time-consuming order requisition processes by presenting a web-based solution tailored for cafeteria operations. Our system automates order requisition, menu planning, and billing processes, enhancing performance and minimizing manual effort through secure coding practices and asynchronous processing techniques. Rigorous testing, including unit, integration, system, and user acceptance testing, validates the system's functionality and reliability. Our findings demonstrate significant improvements in order processing time and accuracy, leading to enhanced operational efficiency and user satisfaction. This research contributes valuable insights into the design and implementation of web-based cafeteria management systems, offering practical solutions for improving service delivery in educational institutions.
Unraveling sauropod diversity in the Portezuelo Formation of Patagonia through a comprehensive analysis of new and existing material
Authors: Gomez Kevin Leonel , Pérez-Moreno Agustín , Meso Jorge Gustavo , Bellardini Flavio , Baiano Mattia Antonio , Pol Diego , Garrido Alberto , Kaluza Jonatan , Muci Luciana , Pittman Michael 
Published: March 2024

Abstract

The Portezuelo Formation preserves an outstanding record of the upper Turonian - lower Coniacian of Gondwana. Despite the discovery of a significant amount of sauropod fossil material from the Formation, only two species have been formally described to date: Malarguesaurus florenciae and Futalognkosaurus dukei. Here we present new sauropod material mostly composed of non-articulated caudal vertebrae that belong to at least two different titanosauriforms on the basis of following features: anterior caudal vertebrae with procoelous-opistoplatyan articulations, transverse processes that reach the posterior articular face of the centrum and neural spines with a lateromedial width of ~ 50% of its anteroposterior length; anterior and middle caudal vertebra with the neural arch restricted to the anterior half of the centrum; middle caudal centrum with circular cross-section. Phylogenetic analysis recovers the new material in close relation to Malarguesaurus within a monophyletic clade sister to Somphospondily. This clade shares large pedicel height with a vertical anterior border on the middle caudal vertebrae, a vertical orientation of the neural spines on the distalmost middle caudal vertebrae and proximalmost posterior caudal vertebrae, and subequal relative lengths of the proximal ulnar condylar processes. The specimens presented here are distinct not only from Malarguesaurus and Futalognkosaurus, but also from other indeterminate titanosaur remains from the same formation. Whilst we err on the side of caution in not naming new taxa here, the two specimens significantly expand what we know about sauropods in the Turonian-Coniacian ecosystems of Patagonia, which will continue to do so as more material is discovered.
A new class of sediment transport models: Derivation and numerical solutions
Authors: Ndengna Ngatcha , Bandji Daniel , Njifenjou Abdou 
Published: March 2024

Abstract
In coastal or estuarine environments the water fluctuations withgreater length of correlations are more intense and modify the meanmotion. The literature does not provide an averaged sedimenttransport model (STM) for coastal zones that accounts for both meanand fluctuating motions over an abrupt mobile bottom. Models basedon water are commonly used to describe sediment transport, but theyare not applicable when the flow becomes turbulent. These modelsonly consider the mean motion. To account the fluctuating motion ina STM, we assume $ |u -\overline{u}|^k \leq \tau^k h, \;\; k>0$ ($h= \mathcal{O}(\varepsilon)$ is the water depth, $\lambda = const$).However, distortion no exist always since during the dam break overerodible bed, the water near the bed can become dense thus weaklyturbulent. To always ensure the turbulence existence, we assume that$\tau = \mathcal{O}(\gamma^\alpha) \;\; \varepsilon^2 \ll \gamma \ll1$ and $\rho = \mathcal{O}(\gamma)$ with $\gamma = const$.Additionally we assume a weakly concentrated approximation ($d_{50}= \mathcal{O}(\varepsilon^\alpha)$, $\delta = \mathcal{O}(\epsilon),1< \alpha <3$) to derive the model. The model obtained in thisstudy builds upon previous work by authors in 2007, 2012, and 2018,while also improving upon more recent models developed in 2022 and2023. The hyperbolic STM is subject to various complexities arisingfrom turbulence and several nonlinear coupled terms. Furthermore,solving this problem still poses a computational challenge in termsof accuracy, convergence, robustness, and efficiency. To addressthis challenge, we propose a new path-conservative method called $\text{HLL}_{**}$, which we combine with a modified Averaging method.The Essentially Non-Oscillatory (AENO) nonlinear reconstructionmethod is used to approximate the model. This method is noteworthybecause it generalizes several HLL-based schemes developed in recentyears. Numerical test cases have been performed.
Peptide Energy Bars as Catalysts for Aerobic Capacity Improvement in Cross- Country Skiers: A Randomized Controlled Trial
Authors: Xiang Mai , Han Qi , Chen Yue , Duan Shenglin , Han Xiaofeng , Sui Xuemei , Ren Chaoxue , Wang Qirong 
Published: March 2024

Abstract
Background
This study investigated the efficacy of peptide energy bars compared to regular protein bars in elite cross-country skiers, providing insights into the metabolic and performance effects of these supplements in order to guide athletes in selecting optimal energy sources for training and competition.
Methods
Nineteen healthy male cross-country skiers were enrolled and assigned to either the peptide bar group (PEP, n = 9) or the protein bar group (PRO, n = 10). A four-week intervention study involving energy bar supplementation was conducted, and pre- and post-intervention assessments were performed to evaluate exercise capacity and metabolic profile.
Results
The study found that within each group, the PEP group and the PRO group showed distinct effects on exercise performance. The PEP group demonstrated improved aerobic capacity, including better performance in 10km roller skating, increased lactate threshold, and reduced resting blood lactate levels. The PRO group enhanced anaerobic capacity, such as improved sprint time, hexagon test performance, and lactate clearance. Metabolomic analysis revealed specific metabolic pathways affected in each group, with the PEP group showing impacts on the alpha-linolenic acid pathway and the PRO group on ketone bodies synthesis, degradation, and vitamin B6 metabolism.
Conclusions
Our findings indicate that peptide energy bars and regular protein bars have comparable effects on exercise performance. However, peptide bars may offer greater advantages in enhancing aerobic capacity. No significant variations were observed in blood metabolite profiles between the two groups, but distinct metabolic pathways exhibited different responses.
The Development of Innovative Techniques for Determining the Properties of Natural Hydraulic Lime
Authors: Mermer Nevin Karamahmut 
Published: March 2024

Abstract

Hydraulic mortars, produced by combining air-curing lime with pozzolans and a water-hardening mortar, were widely used in ancient Greece and Rome. Later in the 18th century, as we learned more about hydraulic properties of materials obtained by burning clay-contaminated limestone, there was a shift in the preferred materials used. Hydraulic and pozzolan lime mortars are used in restoration and eco-friendly building. Hydraulic lime's characterization outside of reactions is unknown. A technique to analyze and properly define changes in hydraulic lime mortars made from natural and synthetic materials is a global priority. The volume expansion and water vapor permeability properties of hydraulic lime make it favorable restoration of heritages. The study aims to increase our understanding of hydraulic lime hydration, monitoring the hydrated phase changes, and use the results to verify content by determining the composition. Combining XRD and FTIR, a method has been devised for the characterization of hydraulic lime.
Evaluation of the Effect of Sarcopenia on Postoperative Major Complications after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Patients with Peritoneal Carcinomatosis
Authors: Havan¹ Nuri , Gülmez² Selçuk , Senger² Aziz Serkan , Uzun² Orhan , Dinçer² Mürşit , Özduman² Ömer , Duman³ Uğur , Avan⁴ Deniz , Polat⁴ Aytaç , Polat² Erdal , Duman² Mustafa 
Published: March 2024

Abstract
Purpose
This study aimed to assess the impact of sarcopenia on postoperative major complications in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis.
Methods
In this longitudinal cohort study included 202 patients treated between January 2018 and September 2023, with 52 undergoing prophylactic procedures. Peritoneal metastases originated from colorectal, gastric, and ovarian cancer; peritoneal mesothelioma; mucinous adenocarcinoma of the appendix; and endometrial cancer. Age, sex, body mass index (BMI), length of hospital stay (LOS), peritoneal cancer index (PCI), competency of cytoreduction (CC), operation time, and primary peritoneal carcinomatosis were recorded. All variables were analysed according to the presence of major complications and sarcopenia.
Results
Significant associations were found between major complications and sarcopenia (p = 0.002), PCI (p = 0.036), operation time (p = 0.015), and LOS (p < 0.001). In sarcopenic patients, significant associations were found with sex (p = 0.035), age (p = 0.025), and BMI (p = 0.001). Multivariate Cox regression analysis identified sarcopenia as an independent risk factor for major complications, tripling the likelihood (p = 0.005). Additionally, PCI score (p = 0.008) and LOS (p < 0.001) were independent risk factors.
Conclusion
This study underscores sarcopenia as an independent risk factor for major complications in CRS/HIPEC patients, with PCI and LOS as additional risk factors.
The leather sector diagnosis: what problems? What solutions? : A Moroccan case study
Authors: Saad Aberkane Mohammed , Otman Aberkane 
Published: March 2024

Abstract
The leather sector remains one of the sectors that encounters a multitude of problems on an international scale, particularly in Morocco. Therefore, we carried out a literature review through which we were able to identify the major problems found within the leather sector. After that, we conducted a case study on the Chouara tannery in the fez Meknes region where we studied the problems found within the sector by using the 5M and SWOT methods as well as the proposal of certain improvement actions with a view to revitalizing the sector. The novelty of our work lies in the proposal of certain functionalities that could play the role of product lifecycle management (PLM) within the sector, such as life management, complaint management and cost management since the notion of PLM is absent within traditional tanneries. In addition, we propose integrating ecological PLM to limit the amount of garbage generated during the execution of tasks.
PIM-GPT: A Hybrid Process-in-Memory Accelerator for Autoregressive Transformers
Authors: Wu Yuting , Wang Ziyu , Lu Wei D. 
Published: March 2024

Abstract
Decoder-only Transformer models such as GPT have demonstrated exceptional performance in text generation, by autore-gressively predicting the next token. However, the efficacy of running GPT on current hardware systems is bounded by low compute-to-memory-ratio and high memory access. Process-in-memory (PIM) architectures can minimize off-chip data movement and utilize high internal bandwidth. They stand out as promising candidates for accelerating memory-bounded tasks such as GPT inference.
In this work, we propose a PIM accelerator, PIM-GPT, which achieves end-to-end acceleration of GPT inference with high performance and high energy efficiency. PIM-GPT leverages DRAM-based PIM designs for executing multiply-accumulate (MAC) operations directly in the DRAM chips, eliminating the need to move matrix data off-chip. Non-linear functions and data communication is supported by an application specific integrated chip (ASIC). At the software level, mapping schemes are designed to maximize data locality and computation parallelism by concatenating and partitioning matrices among DRAM channels and banks to utilize all available in-memory computation units. The efficiency of the PIM-GPT architecture is verified through circuit synthesis and an event-driven clock-cycle accurate simulator. Overall, PIM-GPT achieves 41−137×, 631−1074× speedup and 123−383×, 320−602× energy efficiency over GPU and CPU baseline on 8 GPT models with up to 1.4 billion parameters.
A Case Study for Seismic Resilience of Anchored and Self-Anchored Liquid Storage Tanks in High Seismic Regions
Authors: Erkmen Bulent 
Published: March 2024

Abstract
This study presents seismic performance of two existing at-grade industrial liquid-storage tanks located in the Eastern part of Marmara region, which is a high seismic region in Turkey. The first tank is selfanchored (unanchored) and has been in service for 44 years, while the other tank is mechanically anchored to a reinforced concrete foundation and has been in service for 50 years. Tanks seismic performance is evaluated using tank time-history earthquake analyses with recorded ground motions scaled for each tank site. The liquid content was included in the developed model using provisions of API 650. Tanks base uplift, sliding on the foundation, tank shell and bottom plate damage, and demand on tank anchorage were determined. The results shows that self-anchored tank has base plate uplift and sliding that are larger than the allowable limits while the mechanically anchored tank has acceptable seismic performance with potential seismic damage of tank anchorage system. The findings of this study contribute valuable insight into the seismic performance of existing liquid storage tanks in the region under new seismic regulations and increased seismic loads than those used for their design.
From islands to infectomes: host-specific viral diversity among birds across remote islands
Authors: Grimwood Rebecca M. , Reyes Enzo M. R. , Cooper Jamie , Welch Jemma , Taylor Graeme , Makan Troy , Lim Lauren , Dubrulle Jeremy , McInnes Kate , Holmes Edward C. , Geoghegan Jemma L. 
Published: March 2024

Abstract
Background
Accelerating biodiversity loss necessitates monitoring the potential pathogens of vulnerable species. With a third of New Zealand's avifauna considered at risk of extinction, a greater understanding of the factors that influence viral transmission in this island ecosystem is needed. We used metatranscriptomics to determine the viruses, as well as other microbial organisms (i.e. the infectomes), of seven bird species, including the once critically endangered black robin (Petroica traversi), on two islands in the remote Chatham Islands archipelago, New Zealand.
Results
We identified 19 likely novel avian viruses across nine viral families. Black robins harboured viruses from the Flaviviridae, Herpesviridae, and Picornaviridae, while introduced starlings (Sturnus vulgaris) and migratory seabirds (Procellariiformes) carried viruses from six additional viral families. Potential cross-species virus transmission of a novel passerivirus (family: Picornaviridae) between native (black robins and grey-backed storm petrels) and introduced (starlings) birds was also observed. Additionally, we identified bacterial genera, apicomplexan parasites, as well as a novel megrivirus linked to disease outbreaks in other native New Zealand birds. Notably, island effects were outweighed by host taxonomy as a significant driver of viral composition, even among sedentary birds.
Conclusions
These findings underscore the value of surveillance of avian populations to identity and minimise escalating threats of disease emergence and spread in these island ecosystems. Importantly, they contribute to our understanding of the potential role of introduced and migratory birds in the transmission of microbes and associated diseases, which could impact vulnerable island-endemic species.
Chitin extraction from crab shells by two-step fermentation with Lacticanttacllus pantarum and Pseudomonas aeruginosa
Authors: Zhou Yi , Yang Haoyue , Xing Ronge , Liu Song , Li Kecheng , Li Rongfeng , Yu Huahua , Li Pengcheng 
Published: March 2024

Abstract
There are few reports on the extraction of chitin from crab shells using microbiological methods. In this work, the strain Lacticanttacllus pantarum (LA01) for demineralization (DM) and the strain Pseudomonas aeruginosa (PS01) for deproteinization (DP) were screened from soil, seawater, mud of aquaculture farm, seamount, marine cold spring, probiotic powders, etc. After optimizing the fermentation conditions, LA01 showed the highest activity under the conditions of 2% glucose, 1g crab shells of 18 mesh in 100mL system for 48h, while PS01 performed best with 0.5g crab shells of 60 mesh in 100mL system for 48h. chitin was extracted from crab shells using two-step fermentation method with two scheme: (i) LA01 followed by PS01; (ii) PS01 followed by LA01, and the products were analyzed by FTIR, XRD and SEM. Results showed that 97.55 ± 0.15% of DM and 73.49 ± 0.25% of DP were eliminated by inoculating PS01 followed by LA01. The strong connection between protein and chitin in the crab shells was speculated as the reason of protein residues. Similar structure was observed in the fermented product by the results of FTIR and XRD compared with commercial chitin, indicating the structure of α-chitin. The presence of porous and fibrous structures was observed in crab chitin by two-step fermentation using SEM. The fermentation broth acquired from LA01 contained with various organic acids, lactic acid mostly, with contents of 4238.65mg/L, along with 356.91mg/L acetic acid, which has potential application in inhibiting other bacteria pollution during fermentation.
Prediction of Football Player Performance Using Machine Learning Algorithm
Authors: B Chandra , D Jennet Shinny , M Keshav Adhitya 
Published: March 2024

Abstract
we delve into the popular subject of predicting soccer match outcomes, particularly focused on the local team's games, which often spark enthusiastic discussions among male audiences. The endeavor to model football data has gained traction in recent years, prompting the emergence of diverse methodologies aimed at deciphering the factors influencing a team's victory or defeat, or even predicting match scores. Central to our study is leveraging machine learning and data mining techniques to forecast match results by analyzing historical match data. Employing tools such as WEKA, we identify key features contributing to match outcomes. Through the application of various classifiers including logistic regression, SVM, and Bayesian networks, we rigorously test and refine our predictive models. Ultimately, we propose the most influential features and outline strategies for computing new parameters derived from these features, thereby enhancing the accuracy of our predictions.