bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zooming in on the semantics of French ingressives: a collostructional analysis
Authors: Verroens Filip 
Published: February 2024

AbstractThis article examines the semantic value of the infinitive in the ingressive constructions se mettre à (SMA) and commencer à (COMA) using a distinctive collexeme analysis. We find that the collexemes significant for the construction SMA are fairly homogeneous across the different corpora and can be grouped into the general category of expressive collexemes. The collexemes significant for COMA are more heterogeneous and belong to the category of cognitive collexemes and to semantic fields of sensory and creative acts. The results are compatible with the hypothesis put forward by Verroens and De Cuypere (2023) stating that the overall meaning of the SMA construction is intrinsically punctual. The punctual value of SMA is not only compatible with expressive collexemes, but, moreover, emphasizes their unforeseen and unintentional meaning. Conversely, the incremental value of COMA is consistent with the gradual onset of cognitive and sensory collexemes.
Public Reason Requirements in Bioethical Discourse
Authors: Holm Søren 
Published: February 2024

AbstractThis paper analyzes the use of public reason requirements in bioethical discourse and discusses when such requirements are warranted. By a “public reason requirement,” I mean a requirement that those involved in a particular discourse or debate only use reasons that can properly be described as public reasons. The first part of the paper outlines the concept of public reasons as developed by John Rawls and others and discusses some of the general criticisms of the concept and its importance. The second part then distinguishes between two types of public reason requirements in bioethics. One type is what I will call the orthodox public reason requirement since it hews closely to the original Rawlsian conception. The second is what I will call the expansive public reason requirement, which departs quite radically from the Rawlsian conception and applies the requirement not to policy discourse or policymaking, but to the actions of individuals. Both types of requirements will be analyzed, and some problems in applying public reason requirements in bioethics will be identified. It will be argued that the expansive public reason requirement is misguided. The concluding part argues that requirements of civic civility and what Rawls terms an “inclusive view” of public reason should be important in bioethical discourse.
Visual associative learning to detect early episodic memory deficits and distinguish Alzheimer’s disease from other types of dementia
Authors: Dubbelman Mark A. , Tomassen Jori , van der Landen Sophie M. , Bakker Els , Kamps Suzie , van Unnik Annemartijn A.J.M. , van de Glind Marie-Christine A.B.J. , van der Vlies Annelies E. , Koene Ted , Leeuwis Anna E. , Barkhof Frederik , van Harten Argonde C. , Teunissen Charlotte , van de Giessen Elsmarieke , Lemstra Afina W. , Pijnenburg Yolande A.L. , Ponds Rudolf W.H. , Sikkes Sietske A.M. 
Published: February 2024

AbstractObjective:We investigated how well a visual associative learning task discriminates Alzheimer’s disease (AD) dementia from other types of dementia and how it relates to AD pathology.Methods:3,599 patients (63.9 ± 8.9 years old, 41% female) from the Amsterdam Dementia Cohort completed two sets of the Visual Association Test (VAT) in a single test session and underwent magnetic resonance imaging. We performed receiver operating curve analysis to investigate the VAT’s discriminatory ability between AD dementia and other diagnoses and compared it to that of other episodic memory tests. We tested associations between VAT performance and medial temporal lobe atrophy (MTA), and amyloid status (n = 2,769, 77%).Results:Patients with AD dementia performed worse on the VAT than all other patients. The VAT discriminated well between AD and other types of dementia (area under the curve range 0.70–0.86), better than other episodic memory tests. Six-hundred forty patients (17.8%) learned all associations on VAT-A, but not on VAT-B, and they were more likely to have higher MTA scores (odds ratios range 1.63 (MTA 0.5) through 5.13 for MTA ≥ 3, all p < .001) and to be amyloid positive (odds ratio = 3.38, 95%CI = [2.71, 4.22], p < .001) than patients who learned all associations on both sets.Conclusions:Performance on the VAT, especially on a second set administered immediately after the first, discriminates AD from other types of dementia and is associated with MTA and amyloid positivity. The VAT might be a useful, simple tool to assess early episodic memory deficits in the presence of AD pathology.
Overcoming the relative bandwidth limitations of single VCO frequency synthesizers by implementing a novel PLL architecture
Authors: Braun Tobias T. , Schoepfel Jan , Marquez M. Aldo J. , Pohl Nils 
Published: February 2024

AbstractFrequency-modulated continuous-wave radar systems profit from increasing the absolute bandwidths of the generated frequency chirps to improve range resolution. As the relative bandwidth of SiGe-voltage-controlled oscillators (VCOs) is limited to about 80%, increasing the center frequency fundamentally or via frequency multiplication is the most direct way to increase that absolute bandwidth. However, as some applications require penetration depth, which dramatically decreases with frequency, other solutions are necessary. Therefore, state-of-the-art concepts rely on the down-conversion of generated frequency chirps via two separately stabilized frequency sources. This article implements a novel architecture, offering relative bandwidths of >100% within a single phase-locked loop (PLL). Therefore, two VCOs at different center frequencies are fed into a down-conversion mixer, whose output is directly stabilized via that PLL with one loop filter generating both tuning voltages. Those circuit blocks can be summarized as one equivalent VCO, offering a higher relative bandwidth and a significantly more linear tuning curve. Thereby, a solution to limited relative bandwidths with high VCO gain variation of single VCO synthesizers is offered while substantially reducing the hardware and implementation effort compared to the state-of-the-art.
The Greenhouse Gas Budget of Terrestrial Ecosystems in East Asia Since 2000
Authors: Wang Xuhui , Gao Yuanyi , Jeong Sujong , Ito Akihiko , Bastos Ana , Poulter Benjamin , Wang Yilong , Ciais Philippe , Tian Hanqin , Yuan Wenping , Chandra Naveen , Chevallier Frédéric , Fan Lei , Hong Songbai , Lauerwald Ronny , Li Wei , Lin Zhengyang , Pan Naiqing , Patra Prabir K. , Peng Shushi , Ran Lishan , Sang Yuxing , Sitch Stephen , Takashi Maki , Thompson Rona Louise , Wang Chenzhi , Wang Kai , Wang Tao , Xi Yi , Xu Liang , Yan Yanzi , Yun Jeongmin , Zhang Yao , Zhang Yuzhong , Zhang Zhen , Zheng Bo , Zhou Feng , Tao Shu , Canadell Josep G. , Piao Shilong 
Published: February 2024

AbstractEast Asia (China, Japan, Koreas, and Mongolia) has been the world's economic engine over at least the past two decades, exhibiting a rapid increase in fossil fuel emissions of greenhouse gases (GHGs) and has expressed the recent ambition to achieve climate neutrality by mid‐century. However, the GHG balance of its terrestrial ecosystems remains poorly constrained. Here, we present a synthesis of the three most important long‐lived greenhouse gases (CO2, CH4, and N2O) budgets over East Asia during the decades of 2000s and 2010s, following a dual constraint approach. We estimate that terrestrial ecosystems in East Asia is close to neutrality of GHGs, with a magnitude of between −46.3 ± 505.9 Tg CO2eq yr−1(the top‐down approach) and −36.1 ± 207.1 Tg CO2eq yr−1(the bottom‐up approach) during 2000–2019. This net GHG sink includes a large land CO2sink (−1229.3 ± 430.9 Tg CO2 yr−1based on the top‐down approach and −1353.8 ± 158.5 Tg CO2 yr−1based on the bottom‐up approach) being offset by biogenic CH4and N2O emissions, predominantly coming from the agricultural sectors. Emerging data sources and modeling capacities have helped achieve agreement between the top‐down and bottom‐up approaches, but sizable uncertainties remain in several flux terms. For example, the reported CO2flux from land use and land cover change varies from a net source of more than 300 Tg CO2 yr−1to a net sink of ∼−700 Tg CO2 yr−1. Although terrestrial ecosystems over East Asia is close to GHG neutral currently, curbing agricultural GHG emissions and additional afforestation and forest managements have the potential to transform the terrestrial ecosystems into a net GHG sink, which would help in realizing East Asian countries' ambitions to achieve climate neutrality.
Influence of Spatial Heterogeneity in Sea Surface Temperature on Tropical Cyclone Intensity Over the Western North Pacific
Authors: Sun Jia , Jin Shanshan , Ju Xia , He Hailun , Ding Ruibin , Hu Xiaomin , Xiong Xuejun 
Published: February 2024

AbstractThis study explores the impact of sea surface temperature (SST) spatial heterogeneity on tropical cyclone (TC) intensity through a combination of observations and simulations, aiming to provide a reference for further improving TC intensity forecasting skills. Two distinct patterns of SST spatial heterogeneity are identified based on a statistical analysis of observational data, when the SST at the TC center is above and below 29.3°C, respectively. One is a warm‐core pattern (WCP) with a warm peak SST at the TC center decreasing centrifugally which favors TC development, and the other one is a poleward‐decreasing pattern (PDP) with a warm SST at the south decreasing poleward which suppresses TC development. The numerical simulations confirm the opposite influence of the WCP and the PDP on TC intensity. The WCP intensifies TC intensity by strengthening TC secondary circulation, increasing the conversion from ocean heat energy to TC kinetic energy, and compacting TC structure. In contrast, the PDP weakens TC intensity by inducing opposing responses of these processes. The magnitude of TC intensity change caused by SST spatial heterogeneity is comparable to those caused by a 1°C change in SST at the TC center. These findings offer valuable insights into the role of SST spatial heterogeneity in TC development and provide a new perspective to improve TC intensity forecasting by incorporating SST spatial heterogeneity into statistical‐dynamic models.
Contrasting Responses of Land Surface Temperature and Soil Temperature to Forest Expansion During the Dormant Season on the Qinghai‐Tibet Plateau
Authors: Qu Zhuoran , Li Xiaoyan , Shi Fangzhong 
Published: February 2024

AbstractAs one of the important ecological responses of ecosystem to global climate change, forest expansion can alter land surface energy budget and local microclimate. Land surface temperature (LST) and soil temperature (ST) indicate the above‐ and below‐ground thermal state, respectively. However, the lack of studies on the relationships between LST and ST changes after forest expansion hinders our understanding of the vegetation‐microclimate interactions, especially during the dormant season. We quantified the change of LST (∆LST) and ST (∆ST) after forest expansion in the dormant season on the Qinghai‐Tibet Plateau (QTP), and then explored their differences and linkages. The results showed that forest expansion significantly decreased LST by 0.75 ± 0.20°C, while significantly increased ST in three layers (0–7, 7–28, and 28–100 cm) by 0.31 ± 0.06, 0.29 ± 0.05, and 0.20 ± 0.04°C, respectively. The decreased LST was conducive to the preservation of snow, leading to larger snow depth, larger fractional snow cover and more snow cover days in forests than grasslands, which further promoted the increased ST through enhanced thermal insulation. Furthermore, it is suggested that the cooling impact of forest expansion on LST and warming impact on ST would both be stronger at humid sites than at dry sites. These findings will contribute to understand the vegetation‐microclimate‐snow interactions and the decoupling phenomenon between LST and ST in the dormant season influenced by vegetation change.
Radar Attenuation Characteristics of Low Reflectivity Zones in the Martian South Polar Layered Deposits
Authors: Abu Hashmeh N. , Whitten J. L. , Russell A. T. , Putzig N. E. 
Published: February 2024

AbstractBoth sets of Martian polar layered deposits (PLDs) display semi‐rhythmic reflector stratigraphy in radargrams. The southern PLDs (SPLD), among other peculiarities, also contain widespread, distinctive deposits with few to no reflections that commonly occur at or near the top of the stratigraphic column. Here, we study the low reflectivity zones (LRZs) to determine whether they exhibit radar properties indicative of non‐water ice. We find that the previously reported CO2‐ice LRZ exhibits a distinct radar signature compared to all other LRZs. We also found behavior that suggests that the other LRZs may contribute to increased radar signal attenuation, which does not support a CO2 ice composition. We observe many instances of LRZs comprising the entire SPLD column and find that the radar attenuation varies across different LRZs, suggesting unique properties within each of these deposits. Variable radar attenuation of LRZs may be connected to differences in bulk compositions, radar‐sensitive roughness characteristics, and/or distributions of stratigraphic materials.
Climate and Vegetation of the Miocene of Tierra del Fuego: Filaret Formation
Authors: Sandoval C. A. , Yabe A. , Nishida H. , Hinojosa L. F. 
Published: February 2024

AbstractThe changing climate during the Cenozoic affected the diversity of plants in Patagonia, as species richness tends to increase during warm periods and decrease during cold periods. Precipitation is a significant factor shaping diversity, as shown in the case of central Chile during the Miocene. This study presents a reconstruction of the climate and vegetation in Tierra del Fuego Island, located approximately 52°S, using fossil flora recovered from the Filaret Formation to understand the Miocene epoch, characterized by contrasting global climatic changes. Filaret flora comprises twenty‐seven morpho‐taxa, including nine Nothofagus species and other Gondwanan and Neotropical families, such as Atherospermataceae and Anacardiaceae, in agreement with a forest habitat. Leaf physiognomy climate reconstruction suggests microthermal conditions, with a mean annual temperature of 9.4–11°C and annual precipitation ranging from 985 to 1,130 mm. These conditions are warmer and wetter than the modern record of the area, with a MAT of 6°C and mean annual precipitation of 300 mm. As the Filaret fossil record suggests, the forest habitat under a microthermal climate is consistent with the global climatic reconstruction of the Early Miocene. This Miocene landscape on Tierra del Fuego was possible because the Andes could not rain‐shadow humid westerly winds by this timeframe.
The evolution of preclinical models for myelodysplastic neoplasms
Authors: Mina Alain , Pavletic Steven , Aplan Peter D. 
Published: February 2024

AbstractMyelodysplastic Neoplasms (MDS) are a group of clonal disorders characterized by ineffective hematopoiesis and morphologic dysplasia. Clinical manifestations of MDS vary widely and are dictated in large part by a range of genetic aberrations. The lack of robust in vitro models for MDS has limited the ability to conduct high throughput drug screens, which in turn has hampered the development of novel therapies for MDS. There are very few well-characterized MDS cell lines, and the available cell lines expand poorly in vitro. Conventional xenograft mouse models can provide an in vivo vessel to provide growth of cancer cells, but human MDS cells engraft poorly. Three-dimensional (3D) scaffold models that form human “ossicles” represent a promising new approach and can reproduce the intricate communication between hematopoietic stem and progenitor cells and their environment. Genetically engineered mice utilize specific mutations and may not represent the entire array of human MDS; however, genetically engineered mice provided in vivo proof of principle for novel agents such as luspatercept, demonstrating the clinical utility of this approach. This review offers an overview of available preclinical MDS models and potential approaches to accelerate accurate clinical translation.
Combining thermal scanning probe lithography and dry etching for grayscale nanopattern amplification
Authors: Erbas Berke , Conde-Rubio Ana , Liu Xia , Pernollet Joffrey , Wang Zhenyu , Bertsch Arnaud , Penedo Marcos , Fantner Georg , Banerjee Mitali , Kis Andras , Boero Giovanni , Brugger Juergen 
Published: February 2024

AbstractGrayscale structured surfaces with nanometer-scale features are used in a growing number of applications in optics and fluidics. Thermal scanning probe lithography achieves a lateral resolution below 10 nm and a vertical resolution below 1 nm, but its maximum depth in polymers is limited. Here, we present an innovative combination of nanowriting in thermal resist and plasma dry etching with substrate cooling, which achieves up to 10-fold amplification of polymer nanopatterns into SiO2 without proportionally increasing surface roughness. Sinusoidal nanopatterns in SiO2 with 400 nm pitch and 150 nm depth are fabricated free of shape distortion after dry etching. To exemplify the possible applications of the proposed method, grayscale dielectric nanostructures are used for scalable manufacturing through nanoimprint lithography and for strain nanoengineering of 2D materials. Such a method for aspect ratio amplification and smooth grayscale nanopatterning has the potential to find application in the fabrication of photonic and nanoelectronic devices.
The prognostic role of diet quality in patients with MAFLD and physical activity: data from NHANES
Authors: Huang Jiaofeng , Wu Yinlian , Zheng Jiaping , Wang Mingfang , Goh George Boon-Bee , Lin Su 
Published: February 2024

Abstract
Background and objectives
Dietary control and increased physical activity (PA) are recommended for patients with metabolic (dysfunction-) associated fatty liver disease (MAFLD). However, not all patients can sustain both exercise and a healthy diet. This study explored the interaction between dietary quality, PA levels, and mortality in MAFLD patients.

Methods
The Third National Health and Nutrition Examination Survey and linked mortality data were used in this study. Diet quality was assessed with the Healthy Eating Index (HEI). PA level was calculated by multiply self-reported exercise frequency and its Metabolic Equivalent A high-quality diet was associated. A Cox proportional hazard model was used to explore risk factors for mortality in MAFLD patients.

Results
In total, 3709 participants with MAFLD were included in the final analysis. The median follow-up time was 26.2 (interquartile range 19.3–28.1) years and 1549 (41.8%) deaths were recorded over follow-up. Cox multivariate regression was used to adjust for potential confounders of mortality. The results showed both HEI score and PA level were inversely correlated with all-cause mortality (P < 0.05). In the subgroup analysis stratified by PA level, higher diet quality decreased all-cause mortality, cardiovascular-related mortality and cancer-related mortality in PA inactive of MAFLD patients (P < 0.05), but these correlations were not present in active PA groups.

Conclusion
Healthy diet and physical activity may have different impact as lifestyle interventions for MAFLD. A high-quality diet is associated less mortality in inactive individuals with MAFLD but not in those with active PA levels. Sedentary individuals require healthier diet.
miR-147b mediated suppression of DUSP8 promotes lung cancer progression
Authors: Turkowski Kati , Herzberg Frederik , Günther Stefan , Weigert Andreas , Haselbauer Tamara , Fink Ludger , Brunn David , Grimminger Friedrich , Seeger Werner , Sültmann Holger , Stiewe Thorsten , Pullamsetti Soni S. , Savai Rajkumar 
Published: February 2024

AbstractDual-specificity phosphatase 8 (DUSP8) plays an important role as a selective c-Jun N-terminal kinase (JNK) phosphatase in mitogen-activated protein kinase (MAPK) signaling. In this study, we found that DUSP8 is silenced by miR-147b in patients with lung adenocarcinoma (LUAD), which correlates with poor overall survival. Overexpression of DUSP8 resulted in a tumor-suppressive phenotype in vitro and in vivo experimental models, whereas silencing DUSP8 with a siRNA approach abrogated the tumor-suppressive properties. We found that miR-147b is a posttranscriptional regulator of DUSP8 that is highly expressed in patients with LUAD and is associated with lower survival. NanoString analysis revealed that the MAPK signaling pathway is mainly affected by overexpression of miR-147b, leading to increased proliferation and migration and decreased apoptosis in vitro. Moreover, induction of miR-147b promotes tumor progression in vitro and in vivo experimental models. Knockdown of miR-147b restored DUSP8, decreased tumor progression in vitro, and increased apoptosis via JNK phosphorylation. These results suggest that miR-147b plays a key role in regulating MAPK signaling in LUAD. The link between DUSP8 and miR-147b may provide novel approaches for the treatment of lung cancer.
Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder
Authors: Aranda Selena , Muntané Gerard , Vilella Elisabet 
Published: February 2024

AbstractDDR1 has been linked to schizophrenia (SCZ) and bipolar disorder (BD) in association studies. DDR1 encodes 58 distinct transcripts, which can be translated into five isoforms (DDR1a-e) and are expressed in the brain. However, the transcripts expressed in each brain cell type, their functions and their involvement in SCZ and BD remain unknown. Here, to infer the processes in which DDR1 transcripts are involved, we used transcriptomic data from the human brain dorsolateral prefrontal cortex of healthy controls (N = 936) and performed weighted gene coexpression network analysis followed by enrichment analyses. Then, to explore the involvement of DDR1 transcripts in SCZ (N = 563) and BD (N = 222), we studied the association of coexpression modules with disease and performed differential expression and transcript significance analyses. Some DDR1 transcripts were distributed across five coexpression modules identified in healthy controls (MHC). MHC1 and MHC2 were enriched in the cell cycle and proliferation of astrocytes and OPCs; MHC3 and MHC4 were enriched in oligodendrocyte differentiation and myelination; and MHC5 was enriched in neurons and synaptic transmission. Most of the DDR1 transcripts associated with SCZ and BD pertained to MHC1 and MHC2. Altogether, our results suggest that DDR1 expression might be altered in SCZ and BD via the proliferation of astrocytes and OPCs, suggesting that these processes are relevant in psychiatric disorders.