bluuebunny/crossref_metadata_2025_split huggingface dataset:
The antibiotic crisis: On the search for novel antibiotics and resistance mechanisms
Authors: Van Goethem Marc W. , Marasco Ramona , Hong Pei‐Ying , Daffonchio Daniele 
Published: March 2024

AbstractIn the relentless battle for human health, the proliferation of antibiotic‐resistant bacteria has emerged as an impending catastrophe of unprecedented magnitude, potentially driving humanity towards the brink of an unparalleled healthcare crisis. The unyielding advance of antibiotic resistance looms as the foremost threat of the 21st century in clinical, agricultural and environmental arenas. Antibiotic resistance is projected to be the genesis of the next global pandemic, with grim estimations of tens of millions of lives lost annually by 2050. Amidst this impending calamity, our capacity to unearth novel antibiotics has languished, with the past four decades marred by a disheartening ‘antibiotic discovery void’. With nearly 80% of our current antibiotics originating from natural or semi‐synthetic sources, our responsibility is to cast our investigative nets into uncharted ecological niches teeming with microbial strife, the so‐called ‘microbial oases of interactions’. Within these oases of interactions, where microorganisms intensively compete for space and nutrients, a dynamic and ever‐evolving microbial ‘arms race’ is constantly in place. Such a continuous cycle of adaptation and counter‐adaptation is a fundamental aspect of microbial ecology and evolution, as well as the secrets to unique, undiscovered antibiotics, our last bastion against the relentless tide of resistance. In this context, it is imperative to invest in research to explore the competitive realms, like the plant rhizosphere, biological soil crusts, deep sea hydrothermal vents, marine snow and the most modern plastisphere, in which competitive interactions are at the base of the microorganisms' struggle for survival and dominance in their ecosystems: identify novel antibiotic by targeting microbial oases of interactions could represent a ‘missing piece of the puzzle’ in our fight against antibiotic resistance.
Successful treatment of PASS syndrome with IVIG and anti‐IL‐1 treatment: A case report
Authors: Kırmızıer Gizem , Kılınç Elif Altunel , Yıldırım Nurdan Oruçoğlu , Türsen Ümit 
Published: March 2024

AbstractPASS syndrome is a rare autoinflammatory disease characterized by acne vulgaris, hidradenitis suppurativa, pyoderma gangrenosum, and ankylosing spondylitis. Unlike other autoinflammatory disorders such as PAPA and PASH syndrome, there is no documented gene mutation link. Although there are no established treatment guidelines due to the rarity of these diseases, systemic corticosteroids, biologics, and immunosuppressive drugs are used currently. In our report, we presented a case of PASS syndrome who was unresponsive to adalimumab and in whom we observed improvement in both skin and joint manifestations with intravenous immunoglobulin (IVIG) and anti‐IL‐1 treatment.
Contribution of infectious diseases to the selection ofADH1BandALDH2gene variants in Asian populations
Authors: Deiana Giovanni , Sun Ruinan , Huang Jie , Napolioni Valerio , Ciccocioppo Roberto 
Published: March 2024

AbstractBackgroundThe gene variantsADH1B*2 (Arg48His, rs1229984) andALDH2*2 (Glu504Lys, rs671) are common in East Asian populations but rare in other populations. We propose that selective pressures from pathogen exposure and dietary changes during the neolithic transition favored these variants. Thus, their current association with differences in alcohol sensitivity likely results from phenotypic plasticity rather than direct natural selection.MethodsSamples sourced from the Allele Frequency Database (ALFRED) were utilized to compute the average frequency ofADH1B*2 andALDH2*2 across 88 and 61 countries, respectively. Following computation of the average national allele frequencies, we tested the significance of their correlations with ecological variables. Subsequently, we subjected them to Principal Component Analysis (PCA) and Elastic Net regularization. For comprehensive evaluation, we collected individual‐level phenotypic associations, compiling a Phenome‐Wide Association Study (PheWAS) spanning multiple ethnicities.ResultsFollowing multiple testing correction,ADH1B*2 displayed significant correlations with Neolithic transition timing (r = 0.405,p.adj = 2.013e‐03,n = 57) and historical trypanosome burden (r = −0.418,p.adj = 0.013,n = 57). The first two components of PCA explained 47.7% of the total variability across countries, with the top three contributors being the historical indices of population density and trypanosome and leprosy burdens. Historical burdens of theMycobacteriatuberculosis and leprosy were the sole predictive variables with positive coefficients that survived Elastic Net regularization.ConclusionsOur analyses suggest thatMycobacteriamay have played a role in the joint selection ofADH1B*2 andALDH2*2, expanding the “toxic aldehyde hypothesis” to includeMycobacterium leprae. Additionally, our hypothesis, linked to dietary shifts from rice domestication, emphasizes nutritional deficiencies as a key element in the selective pressure exerted byMycobacteria. This offers a plausible explanation for the high frequency ofADH1B*2 andALDH2*2 in Asian populations.
Investigation of polymorphisms in BMP2, BMP4, SMAD6 and RUNX2 genes and pulp stones
Authors: Thuller Katherine Azevedo Batistela Rodrigues , Antunes Lívia Azeredo Alves , Kublitski Prescila Mota de Oliveira , Brancher João Armando , Baratto‐Filho Flares , Küchler Erika Calvano , Silva‐Sousa Alice Corrêa , Sousa‐Neto Manoel Damião , Gabardo Marilisa Carneiro Leão , Antunes Leonardo Santos 
Published: March 2024

AbstractThis study aimed to assess the association between genetic polymorphisms in BMP2 (rs1005464 and rs235768), BMP4 (rs17563), SMAD6 (rs2119261 and rs3934908) and RUNX2 (rs59983488 and rs1200425) and pulp stones (PS). A total of 117 participants, consisting of 63 individuals with PS and 54 without PS, were included. Digital radiographs and a demographic/clinical questionnaire were used. Genomic DNA from salivary cells was genotyped via real‐time polymerase chain reaction. Statistical analyses, including Chi‐Square, Fisher's exact tests, Poisson regression and dimensionality reduction, were conducted. The rs2119261 polymorphism in the SMAD6 gene showed an association with genotype distribution in the recessive model (p = 0.049). The T–T haplotype in the SMAD6 gene (rs2119261 and rs3934908) was more prevalent in the control group and significantly linked with PS (p = 0.029). No associations were found between PS risk and genetic polymorphisms in BMP2, BMP4 and RUNX2. Polymorphisms in the SMAD6 gene were associated with PS.
Ancient labor satisfied, exploited, and relieved, expressed in the modern era
Authors: Rowland Marty 
Published: March 2024

AbstractLabor faces a universal process of increasing exploitation as the following processes converge: Labor is increasingly divorced from a community purpose; the community's economy becomes privatized, which leads to debt bondage and the loss of personal land or availability of land for personal use. This process is repeated from early records of 10,000 BC to the present day. In ancient times, a wise ruler would respond to widespread debt bondage by canceling private debts for the sake of the community. However, there are now no wise rulers on the horizon to cancel debts. This paper may give those who labor, inspiration to continue their struggle for wealth distribution equity.
Two Row Repair: A trilogy
Authors: Vidali Debra 
Published: March 2024

AbstractThe Two Row Repair trilogy refuses erasure as it tracks a journey of attempted recovery and repair, using the Two Row Wampum (Kaswenta) as inspiration, model, and directive. The Two Row Wampum, a foundational agreement made between Haudenosaunee and Dutch in 1613, extends into the present as a promise between Haudenosaunee and people of European descent to co‐exist in peace, respect, and friendship, and in common stewardship for all orders of life. The author, a tenth‐generation Dutch descendant settler, received first place in the 2023 Society for Humanistic Anthropology's 37th Annual Ethnographic Poetry Competition for Parts II and III of this trilogy.
Short‐term reduction of dietary gluten improves metabolic‐dysfunction associated steatotic liver disease: A randomised, controlled proof‐of‐concept study
Authors: Armandi Angelo , Bespaljko Helena , Mang Alexander , Huber Yvonne , Michel Maurice , Labenz Christian , Galle Peter R. , Neerukonda Manjusha , Bugianesi Elisabetta , Schuppan Detlef , Schattenberg Jörn M. 
Published: March 2024

SummaryBackgroundThe current management of metabolic dysfunction‐associated steatotic liver disease (MASLD) relies on lifestyle intervention. Prior studies have shown that nutritional wheat amylase trypsin inhibitors (ATI) activate toll‐like receptor 4 on intestinal myeloid cells to enhance intestinal and extra‐intestinal inflammation, including the promotion of murine MASLD, insulin resistance and liver fibrosis.AimsWe aimed to assess the impact of ATI (gluten)‐free diet in liver as well as metabolic parameters of biopsy‐proven MASLD patients.MethodsWe performed a 6‐week, proof‐of‐concept 1:1 randomised controlled trial of an ATI‐free diet. The controls followed a balanced diet recommended by the German Nutrition Society. We assessed changes in controlled attenuation parameter (CAP), body mass index (BMI) and homeostatic model assessment of insulin resistance (HOMA‐IR). Patient‐reported outcomes were assessed by the CLDQ‐NASH questionnaire. Forty‐five patients were consecutively enrolled (21 in the intervention arm and 24 in the control arm).ResultsThree patients from each arm discontinued the study. In the ATI‐free diet group, a significant decrease in BMI (p = 0.018), CAP (p = 0.018) and HOMA‐IR (p = 0.042) was observed at 6 weeks. The mean difference in CAP between the two arms at week 6 was 30.5 dB/m (p = 0.039), with a delta significantly higher in the ATI‐free diet group (p = 0.043). Only an ATI‐free diet could achieve a significant improvement in CLDQ‐NASH domains (p value for total scoring: 0.013).ConclusionsA short‐term ATI‐free diet leads to significant improvements in liver and metabolic parameters, as well as patient‐reported outcomes with good tolerability. A larger follow‐up study is justified to corroborate these findings.Clinical trial number: NCT04066400.
Visual reconstructions of endometriosis pain: An interdisciplinary visual methodology for illness representation
Authors: Bullo Stella , Hearn Jasmine Heath 
Published: March 2024

AbstractObjectivesEndometriosis is a chronic condition in which tissue resembling the endometrium grows outside of the womb, causing severe chronic pain. Research demonstrates the physical, emotional and quality of life impact on people with endometriosis, but pain is reportedly difficult to communicate, resulting in lengthier diagnosis. This work aimed to gain insight into the value of imagery production as a pain communication strategy through a novel synergy of psychological and linguistic/socio‐semiotic approaches.DesignA qualitative, multimodal, participant‐generated imagery study.MethodsInterpretative phenomenological analysis (IPA) and conceptual metaphor and metonymy analysis were utilized to examine visual representations of endometriosis pain. Data were collected in two focus groups with four and six women, respectively; all with a diagnosis of endometriosis, aged 25–40 years old (M = 34.5, SD = 4.2) and a mean diagnosis delay of 8.4 years (SD = 3.6).ResultsThe overarching theme across visual representations was ‘Pain as Physical Violence’ with ‘colour as emotional representation’, ‘texture as sensory qualities’ and ‘materials as sensation’ as sub‐themes. These are realized through metaphorical and metonymical relations in both the visual representations as well as the accompanying linguistic representation of the process.ConclusionsThis study demonstrates the value of a creative mixed‐methodologies approach to capture experiential aspects of pain and its impact that are not verbalized in linguistic accounts alone. This can facilitate a deeper understanding of one's pain, acting as a medium for therapeutic adjustment to occur, while facilitating effective and empathic patient–professional conversations surrounding pain.
Incidence, mortality and survival rates of lip, oral cavity and salivary glands cancers in Singapore: A half‐century time trend analysis (1968–2017)
Authors: Peres Marco A. , Li Huihua , Nascimento Gustavo G. , Leite Fabio R. M. 
Published: March 2024

AbstractObjectivesTo examine trends in incidence and mortality and evaluate overall survival (OS) of oral cancer in Singapore between 1968 and 2017.MethodsAll diagnosed oral cancers by anatomical sites and population size were extracted from the Singapore Cancer Registry and the Department of Statistics Singapore. The trend of age‐standardized incidence rate (ASIR) and mortality rate (ASMR) (per 100 000 person‐years) of the lip, oral cavity and salivary gland cancers were evaluated by Prais‐Winsten regressions for each ethnicity and gender. Kaplan–Meier curves were performed to evaluate the OS by anatomical sites in each age group by ethnicity and sex.ResultsOverall, 49, 3494 and 1066 people were diagnosed, and 28, 2310 and 476 died from lip, oral cavity and salivary gland cancers, respectively. The oral cavity cancer ASIR and ASMR reduced from 3.07 (1968–1972) to 2.01(2008–2012) and from 2.06 (1978–1982) to 1.21 (2013–2017) per 100 000 person‐years, respectively, with both highest in Indians throughout the whole period. Male:Female ratio ranged from 3.43 (1973–1977) to 1.75 (2013–2017) and from 3.41 (1978–1982) to 2.40 (2013–2017) for ASIR and ASMR, respectively. However, both salivary gland cancer ASIR and ASMR increased from 0.50 (1968–1972) to 0.80 (2008–2012) and from 0.18 (1968–1982) to 0.42 (1988–1992) per 100 000 person‐years, respectively, with both higher in males since 1993. Oral cavity cancer ASIR decreased for males aged ≥60, and Indian females ≥25, but increased among Chinese females aged ≥60. Oral cavity cancer ASMR decreased among Chinese aged 25–59, and among Malay males and Indian females. Salivary gland cancer ASIR increased among Chinese males aged ≥60 and Malay males aged 25–59; while ASMR increased among Chinese males aged ≥60. The median OS for oral cavity, lip and salivary gland cancers were 3.0, 9.3 and 18.1 years, respectively, with females surviving longer than males.ConclusionsSingapore has experienced a decline in the incidence and mortality of lip, oral cancer, an increase in in the incidence and mortality of salivary gland cancer, with an increase in the median overall survival rate. Monitoring the magnitude of oral cancer burden and the demographic, and temporal variations is necessary for tailoring health planning and setting priorities for future clinical care and research.
Use of thyroid hormones in hypothyroid and euthyroid patients: A survey of members of the Endocrine Society of Australia
Authors: Lafontaine Nicole , Brown Suzanne J. , Perros Petros , Papini Enrico , Nagy Endre V. , Attanasio Roberto , Hegedüs Laszlo , Walsh John P. 
Published: March 2024

AbstractObjectiveHypothyroidism is a common endocrine condition usually managed with levothyroxine (LT4). However, controversy remains around the use of liothyronine (LT3). We aimed to investigate the practices of Australian endocrinologists when managing patients with hypothyroidism, their use of LT3 + LT4 combination therapy and use of thyroid hormones in euthyroid patients.Design and ParticipantsMembers of the Endocrine Society of Australia (ESA) were invited to participate in an online questionnaire.MeasurementsWe analysed questionnaires that had complete demographic data.ResultsEighty‐seven questionnaires fulfilled the criteria. LT4 was used as first line treatment for hypothyroidism by all respondents. Only 45% reported that their patients were dispensed the brand of LT4 that they recommend. LT3 (alone or in combination) was prescribed by 44% in their clinical practice. Although 49% of respondents would consider LT3 + LT4 in patients with normal TSH who had ongoing symptoms of hypothyroidism, the inability of LT4 to restore normal physiology was ranked the least likely explanation for persistent symptoms and only 32% would consider it for themselves if they were diagnosed with hypothyroidism. The majority (55%), in accordance with evidence, would not prescribe thyroid hormone to euthyroid individuals but 39% would consider use in euthyroid female infertility with high levels of thyroid antibodies and 11% in euthyroid patients with a simple goitre growing over time. LT4 use in pregnancy was variable among members.ConclusionsAustralian endocrinologists mostly follow international guidelines when prescribing thyroid hormone therapy and many prescribe combination LT3 and LT4 therapy, particularly for patients who remain symptomatic on LT4 monotherapy. Prescribing practices are largely similar to other countries who have completed similar questionnaires.
Mucosal cyst aspiration in conjunction with maxillary sinus elevation: A clinical cohort study
Authors: Testori Tiziano , Scaini Riccardo , Deflorian Matteo , Taschieri Silvio , Decker Ann M. , Saleh Muhammad , Zuffetti Francesco , Saibene Alberto Maria , Felisati Giovanni , Wallace Stephen S. , Francetti Luca , Wang Hom‐Lay , Del Fabbro Massimo 
Published: March 2024

AbstractIntroductionPatients with mucosal cysts in the maxillary sinus require special consideration in patients who require implant therapy for the restoration when undergoing implant therapy for the restoration of the posterior maxillary dentition. Treatment strategies for these clinical situations remain controversial in the literature. Thus, this study seeks to describe a safe and effective therapeutic strategy for sinus augmentation in patients with pre‐existing maxillary antral cysts.MethodsA total of 15 patients and 18 sinuses were consecutively enrolled in this cohort study and underwent maxillary antral cyst treatment by needle aspiration and simultaneous maxillary sinus augmentation (MSA). During surgical procedures, threeimplants (Zimmer Biomet, Indiana, USA) were positioned in 11 sinuses and two implants (Zimmer Biomet, Indiana, USA) were positioned in 5 sinuses.ResultsOverall implant success and survival rates were 100% and 97.8%, respectively at 1 year and 5‐year follow‐ups. Crestal bone resorption averaged 0.3 ± 0.2 mm 5‐year post‐loading, showing bone stability. Implant survival rate at 5‐year follow‐up expressed predictability of the technique comparable to historical data when MSA was performed alone. Crestal bone resorption averaged 0.3 ± 0.2 mm 5 years post‐loading and shows bone stability utilizing mucosal cyst aspiration with concomitant MSA procedures. Quality of life evaluation at 1‐week post‐op showed similar results to published historical data. In 81% (13 sinuses), the CBCT examination at 5‐year follow‐up showed no cyst reformation, in 19% (3 sinuses) cyst reformation was visible, but smaller in size when compared to the pre‐op CBCT evaluation, and all the patients were asymptomatic.ConclusionsMaxillary sinus mucosal cyst aspiration with concomitant MSA, may be a viable option to treat maxillary sinus cyst.
Beyond cultural norms: how does historical rice farming affect modern firms' family control?
Authors: Fan Chenchen , Jiang Mingming , Zhang Bo 
Published: March 2024

AbstractThe private sector contributes the majority of China's GDP, with family firms responsible for most of the contribution. Prior studies find that firms' family control is influenced by certain cultural norms, such as family ties. This study explores the underlying historical and agricultural roots of these cultural norms that influence modern businesses. Combining a set of high‐quality, nationally representative Chinese firm and household surveys with prefectural data, we first show the positive impact of rice farming on family control of local firms. We establish robust causal inferences by exploring the impact of historical agricultural legacies and discussing alternative measures, spatial autocorrelations, omitted variables, instrumental variables and self‐selection. More importantly, our results demonstrate that the rice cultivation practice enhances the local people's preferences for strong family ties. Instead of claiming a direct role of these cultural traits as in the existing literature, we recast them as cultural mediators and persistent channels through which historical rice farming can shape contemporary corporate structure.
TRANSLATION IN HISTORY AND METAHISTORY1
Authors: Lianeri Alexandra 
Published: March 2024

ABSTRACTTheo Hermans's Translation and History: A Textbook offers an insightful, clear, and sophisticated account of debates in translation history as a transdisciplinary field that remained, until recently, at the margins of historiographical debates. It discusses essential theoretical and methodological tools through which historians of translation may wrestle with the problem of defining their object; with modalities of historicizing associated with specific fields and perspectives (including, for instance, memory studies, microhistory, and the history of concepts); and with questions of context, temporality, space, and agency by accounting for translation's transformative movement, migration, and metamorphosis. This review essay follows the book's journey in and out of disciplinary and conceptual borders in order to discuss some of the stakes at play in it, especially problems pertaining to the delimitation of translation as a differential, but distinct, object of historical research, one that lays bare the power of translations to mobilize cultural works and frontiers. By the same token, it attempts to inscribe a translation paradigm into historical theory and, crucially, into debates that shift our focus from rigid historiographical borders toward mobilizing and transformative motifs, identities, and domains of history. This focus grants a new orientation to (translation) history, setting malleability, thresholds, mobility, and resistance to movement at the center of ongoing attempts to configure alternative spatialities, temporalities, subjects, and worlds of the past beyond conventional accounts of contextualizing, periodizing, and only human history.