bluuebunny/crossref_metadata_2025_split huggingface dataset:
Piericidins C7 and C8, New Cytotoxic Antibiotics Produced by a Marine Streptomyces sp.
Authors: Hayakawa Yoichi , Shirasaki Shingo , Shiba Sayaka , Kawasaki Takashi , Matsuo Yoshihide , Adachi Kyoko , Shizuri Yoshikazu 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Mannich‐Like Reactions of Ester Enolates Generated on Sugar Templates: A Novel Access to a Key Intermediate for 1β‐Methylcarbapenem Synthesis.
Authors: Sasaki Daisuke , Sawamoto Daisuke , Takao Ken‐ichi , Tadano Kin‐ichi , Okue Masayuki , Ajito Keiichi 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Supramolecular Hydrogel Formed by Glucoheptonamide of L‐Lysine: Simple Preparation and Excellent Hydrogelation Ability.
Authors: Suzuki Masahiro , Owa Sanae , Shirai Hirofusa , Hanabusa Kenji 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Self‐Assembly of Carbazole‐Containing Gelators: Alignment of the Chromophore in Fibrous Aggregates.
Authors: Yabuuchi Kazuhiro , Tochigi Yusuke , Mizoshita Norihiro , Hanabusa Kenji , Kato Takashi 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Molecular Organogels of the Sodium Salt of (R)‐12‐Hydroxystearic Acid and Their Templated Syntheses of Inorganic Oxides.
Authors: Huang Xiao , Weiss Richard G. 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Composites of N,N′‐Bis‐(pyridyl) Urea‐Dicarboxylic Acid as New Hydrogelators — A Crystal Engineering Approach.
Authors: Adarsh N. N. , Kumar D. Krishna , Dastidar Parthasarathi 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Exploring Molecular Recognition Pathways within a Family of Gelators with Different Hydrogen Bonding Motifs.
Authors: Hardy John G. , Hirst Andrew R. , Ashworth Ian , Brennan Colin , Smith David K. 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enhanced Gelation Property due to Intramolecular Hydrogen Bonding in a New Series of Bis(amino Acid)‐Functionalized Pyridine‐2,6‐dicarboxamide Organogelators.
Authors: Chow Hak‐Fun , Wang Guo‐Xin 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
ILGAR (Ion Layer Gas Reaction) — A Versatile Low‐Cost Method for the Deposition of High Quality Thin Semiconductor and Insulator Layers
Authors: Fischer Ch.‐H. , Allsop N. , Baer M. , Muffler H.‐J. , Lux‐Steiner M. C. 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Enantioselective Morita—Baylis—Hillman Reaction and Its Aza Counterpart
Authors: Masson Geraldine , Housseman Christopher , Zhu Jieping 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Fascinating Organosulfur Functionalities: Polychalcogens as Diatomic Sulfur Sources
Authors: Zysman‐Colman Eli , Harpp David N. 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cardiac Resynchronization Therapy and its Potential Proarrhythmic Effect
Authors: Basu Ray Indranill , Fendelander Lahn , Singh Jagmeet P. 
Published: September 2007

AbstractCardiac resynchronization therapy (CRT) has become an established adjunctive treatment to optimal pharmacologic therapy in patients with advanced chronic heart failure (CHF), diminished left ventricular (LV) function and intraventricular conduction delay. Although CRT has been shown to improve ventricular hemodynamics, quality of life and exercise capacity, there is some evidence that it may rarely potentiate ventricular arrhythmias. As CRT is considered for an expanded population of CHF patients, and left‐sided pacing is considered as an option for pacemaker‐indicated patients (potentially without defibrillator backup), the effect of these pacing modalities on the incidence of ventricular tachyarrhythmia must be systematically studied and mechanistically understood. Strategies to prospectively predict the proarrhythmic potential of LV epicardial pacing need to be developed, and therapy accordingly individualized. This review attempts to summarize the current information on proarrhythmia in resynchronization therapy. Copyright © 2007 Wiley Periodicals, Inc.
Preventing Cardiovascular Disease in Women: An Update
Authors: Wenger Nanette K. 
Published: September 2007

AbstractCoronary heart disease (CHD) continues to be the leading cause of death among women in the United States. Evidence‐based guidelines of the American Heart Association (AHA) offer clinicians recommendations for preventing CHD in women delineating particular lifestyle, risk factor, and pharmacologic interventions. Cigarette smoking, physical inactivity, inappropriate diet, dyslipidemia, hypertension, diabetes mellitus, and metabolic syndrome contribute to the risk of CHD in women, as in men. Lifestyle interventions substantially reduce that risk. Many women, however, require pharmacotherapy to control hypertension, dyslipidemia, and diabetes to levels required for decreasing risk. New findings from clinical trials featuring women may enhance their CHD risk prediction and treatment. However, high coronary risk in many women continues to be underrecognized, and women remain undertreated with statins and other therapeutic agents. Copyright © 2007 Wiley Periodicals, Inc.
Giancarlo Rastelli: The Scientist, the Man
Authors: Squarcia Umberto , Squarcia Antonella 
Published: September 2007

AbstractDoctor Giancarlo Rastelli graduated from the University of Parma, Italy (cum laude) in July 1957, and in 1961, moved to the Mayo Clinic, Rochester, New York.The name of Dr. Rastelli is recognized worldwide for the classification of the atrioventricular (AV) canal and for the procedure relating to the anatomical repair of transposition of the great arteries (TGA) with ventricular septal defect (VSD) and pulmonary stenosis (PS). The most extraordinary aspect of his successful research work was that it was mostly done during the five years when Dr. Rastelli was fighting against his fatal illness. He died at the age of 36 years. Dr. Rastelli's fame as a scientist now belongs to the history of medicine. Copyright © 2007 Wiley Periodicals, Inc.
AKT/NF‐κB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies
Authors: Dell'Eva Raffaella , Ambrosini Claudia , Vannini Nicola , Piaggio Giovanna , Albini Adriana , Ferrari Nicoletta 
Published: September 2007

AbstractBACKGROUND.Leukemias are dependent on Akt/NF‐κB activation and angiogenesis.METHODS.The antiangiogenic Akt/NF‐κB inhibitor xanthohumol (XN) has in vitro activity against acute and chronic myelogenous leukemia cell lines (AML, CML) and fresh samples from patients were investigated.RESULTS.Inhibition of cell proliferation is associated with induction of apoptosis and reduced VEGF secretion. Decreased cell invasion, metalloprotease production, and adhesion to endothelial cells observed in the presence of XN could prevent in vivo life‐threatening complications of leukostasis and tissue infiltration.CONCLUSIONS.As endothelial cells and hematopoietic cells are mutually correlated in their development and growth, targeting both tumor cells and endothelial cells with agents possessing cytotoxic and antiangiogenic activities may lead to synergistic antitumor effects interrupting a reciprocal stimulatory loop between leukemia and endothelial cells. Cancer 2007. © 2007 American Cancer Society.
Weekly docetaxel versus docetaxel/gemcitabine in the treatment of elderly or poor performance status patients with advanced nonsmall cell lung cancer
Authors: Hainsworth John D. , Spigel David R. , Farley Cindy , Shipley Dianna L. , Bearden James D. , Gandhi Jitendra , Ann Houston Gerry , Anthony Greco F. 
Published: September 2007

AbstractBACKGROUND.The aim of this study was to compare the efficacy of single‐agent weekly docetaxel with the combination of docetaxel and gemcitabine in elderly and/or poor performance status patients with advanced nonsmall cell lung cancer (NSCLC).METHODS.Previously untreated patients with stage IIIB/IV NSCLC who were either >65 years old or had an Eastern Cooperative Oncology Group (ECOG) performance status 2 were eligible. Patients were randomized to receive weekly docetaxel (36 mg/m2) Days 1, 8, and 15 or docetaxel (30 mg/m2)/gemcitabine (800 mg/m2) Days 1, 8, and 15. Both regimens were repeated on 28‐day cycles for 6 cycles or until disease progression.RESULTS.Three hundred fifty patients were randomized, and 345 received treatment. The median age of patients was 74 years; 38% were >75 years old, and 35% had ECOG performance status 2. Intent‐to‐treat analysis showed median survivals of 5.5 months versus 5.1 months in the groups receiving docetaxel/gemcitabine versus weekly docetaxel, respectively (P = .65). There were no survival differences detected with docetaxel/gemcitabine versus weekly docetaxel in the 223 patients with good performance status (7.2 months vs 8.0 months, respectively) or in the 122 poor performance status patients (3.8 months vs 2.9 months, respectively). Median time‐to‐progression was longer in patients who received docetaxel/gemcitabine (4.8 months vs 2.9 months; P = .004). Both regimens were generally well tolerated.CONCLUSIONS.Treatment with docetaxel/gemcitabine produced a modest improvement in time‐to‐progression but had no impact on survival when compared with single‐agent weekly docetaxel in this group of patients. Results with both regimens were disappointing, particularly in patients with poor performance status. Improved treatment for these patients will require the introduction of novel, well‐tolerated, targeted agents. Cancer 2007. © 2007 American Cancer Society.
Growth and characterization of magneto‐optical YFeO3 crystals
Authors: Shen Hui , Xu Jiayue , Wu Anhua , Yu Jinxing , Liu Yan , Luo Liqing 
Published: September 2007

AbstractThe floating zone growth of magneto‐optical crystal YFeO3 has been investigated. The polycrystalline feed rod was prepared by a pressure of 250MPa and sintering at about 1500°C. A crack‐ free YFeO3 single crystal has been successfully grown. The crystal preferred to crystallize along <100> direction with about 10° deviation. The X‐ray rocking curve of the crystal has a FWHM of 24 arcsec, confirming the high crystal quality of the sample. The (100) plane was etched by hot phosphoric acid and the dislocation density was about 104/cm2. A thin outer layer with Y2O3‐rich composition was found at the periphery of as‐grown crystals, which was attributed to the Fe2O3 evaporation during growth. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The sexually dimorphic expression of L7/SPA, an estrogen receptor coactivator, in zebra finch telencephalon
Authors: Duncan Kelli A. , Carruth Laura L. 
Published: September 2007

AbstractSex differences in the zebra finch (Taeniopygia guttata) brain are robust and include differences in morphology (song control nuclei in males are significantly larger) and behavior (only males sing courtship songs). In zebra finches, hormonal manipulations during development fail to reverse sex differences in song nuclei size and suggest that the classical model of sexual differentiation is incomplete for birds. Coactivators act to initiate transcriptional activity of steroid receptors, and may help explain why hormonal manipulations alone are not sufficient to demasculinize the male zebra finch brain. The present study investigated the expression and localization of L7/SPA (an estrogen receptor coactivator) mRNA and protein expression across the development of zebra finch song nuclei from males and females collected on P1 (song nuclei not yet formed), P10 (posthatch day 10, song nuclei formed), P30 (30 days posthatch, sexually immature but song nuclei formed and birds learning to sing), and adult birds (older than 65 days and sexually mature). Northern blot analysis showed a significant sex difference in P1 and adult L7/SPA mRNA expression while Western blot analysis also showed enhanced expression in the male brain at all age points. Both in situ hybridization and immunohistochemistry demonstrated that L7/SPA mRNA and protein were located in the song nuclei as well as expressed globally. Elevated coactivator expression may be a possible mechanism controlling the development of male song control nuclei, and coactivators such as L7/SPA may be important regulators of the masculinizing effects of estradiol on brain sexual differentiation. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007.
Temporal and spatial regulation of bone morphogenetic protein signaling in late lung development
Authors: Alejandre‐Alcázar Miguel A. , Shalamanov Petar D. , Amarie Oana V. , Sevilla‐Pérez Julia , Seeger Werner , Eickelberg Oliver , Morty Rory E. 
Published: September 2007

AbstractBone morphogenetic proteins (BMPs) play important roles in early lung development. No study to date has addressed a role for BMP signaling in late lung development. We describe changes in the expression and localization of BMP receptors (Bmpr1a, Bmpr1b, and Bmpr2) and Smad (Smad1, Smad4, Smad5, and Smad8) intracellular signaling proteins during the saccular and alveolarization stages of late lung development. BMP signaling, assessed by Smad1/5 phosphorylation, nuclear translocation, and induction of id1, id2, and id3 gene expression, was evident throughout late lung development. Our data indicate that BMP signaling is active during late lung development, and points to roles for the BMP system in septal and vascular development, and in the homeostasis of the epithelial layer of large conducting airways in the mature lung. Developmental Dynamics 236:2825–2835, 2007. © 2007 Wiley‐Liss, Inc.
Nucleolar colocalization of TAF1 and testis‐specific TAFs during Drosophila spermatogenesis
Authors: Metcalf Chad E. , Wassarman David A. 
Published: September 2007

AbstractIn Drosophila, testis‐specific TBP‐associated factors (tTAFs) predominantly localize to spermatocyte nucleoli and regulate the transcription of genes necessary for spermatocyte entry into meiosis. tTAFs are paralogs of generally expressed TAF subunits of transcription factor IID (TFIID). Our recent observation that the generally expressed TAF1 isoform TAF1‐2 is greatly enriched in testes prompted us to explore the functional relationship between general TAFs and tTAFs during spermatogenesis. Analysis by immunofluorescence microscopy revealed that among the general TFIID subunits examined (TATA‐box binding protein [TBP], TAF1, TAF4, TAF5, and TAF9), only TAF1 colocalized with the tTAF Mia in spermatocyte nucleoli. Nucleolar localization of TAF1, but not Mia, was disrupted in tTAF mutant flies, and TAF1 dissociated from DNA prior to Mia as spermatocytes entered meiosis. Taken together, our results suggest stepwise assembly of a testis‐specific TFIID complex (tTFIID) whereby a TAF1 isoform, presumably TAF1‐2, is recruited to a core subassembly of tTAFs in spermatocyte nucleoli. Developmental Dynamics 236:2836–2843, 2007. © 2007 Wiley‐Liss, Inc.
TFII‐I gene family during tooth development: Candidate genes for tooth anomalies in Williams syndrome
Authors: Ohazama Atsushi , Sharpe Paul T. 
Published: September 2007

AbstractWilliams syndrome is a rare congenital disorder involving the cardiovascular system, mental retardation, distinctive facial features, and tooth anomalies. It is caused by the heterozygous deletion of ∼1.6 Mb encompassing 28 genes on human chromosome 7q11.23. It has been suggested that the genes responsible for craniofacial anomalies are located in the telomeric end region, which harbors three members of the TFII‐I gene family (Tassabehji et al. [2005] Science 310:1184). To recognize potential candidate genes for the tooth anomalies in Williams syndrome, we carried out comparative in situ hybridization analysis of members of TFII‐I gene family during murine odontogenesis. Gtf2i showed widespread expression in the developing head but was higher in the developing teeth than surrounding tissues throughout tooth development. At the bud stage, Gtf2ird1 and Gtf2ird2 were expressed in the epithelial buds. At the early bell stage, expression of Gtf2ird1 and Gtf2ird2 was observed in preameloblasts and preodontoblasts. Developmental Dynamics 236:2884–2888, 2007. © 2007 Wiley‐Liss, Inc.
Conservation of IL‐6 trans‐signaling mechanisms controlling L‐selectin adhesion by fever‐range thermal stress
Authors: Appenheimer Michelle M. , Girard Rachael A. , Chen Qing , Wang Wan‐Chao , Bankert Katherine C. , Hardison Joy , Bain Mark D. , Ridgley Frank , Sarcione Edward J. , Buitrago Sandra , Kothlow Sonja , Kaspers Bernd , Robert Jacques , Rose‐John Stefan , Baumann Heinz , Evans Sharon S. 
Published: September 2007

AbstractFever is associated with improved survival during infection in endothermic and ectothermic species although the protective mechanisms are largely undefined. Previous studies indicate that fever‐range thermal stress increases the binding activity of the L‐selectin homing receptor in human or mouse leukocytes, thereby promoting trafficking to lymphoid tissues across high endothelial venules (HEV). Here, we examined the evolutionary conservation of thermal regulation of L‐selectin‐like adhesion. Leukocytes from animals representing four taxa of vertebrates (mammals, avians, amphibians, teleosts) were shown to mediate L‐selectin‐like adhesion under shear to MECA‐79‐reactive ligands on mouse HEV in cross‐species in vitro adherence assays. L‐selectin‐like binding activity was markedly increased by fever‐range thermal stress in leukocytes of all species examined. Comparable increases in L‐selectin‐like adhesion were induced by thermal stress, IL‐6, or the IL‐6/soluble IL‐6 receptor fusion protein, hyper‐IL‐6. Analysis of the molecular basis of thermal regulation of L‐selectin‐like adhesion identified a common IL‐6 trans‐signaling mechanism in endotherms and ectotherms that resulted in activation of JAK/STAT signaling and was inhibited by IL‐6 neutralizing antibodies or recombinant soluble gp130. Conservation of IL‐6‐dependent mechanisms controlling L‐selectin adhesion over hundreds of millions of years of vertebrate evolution strongly suggests that this is a beneficial focal point regulating immune surveillance during febrile inflammatory responses.
Frequent occurrence of deletions in primary mediastinal B‐cell lymphoma
Authors: Kimm Lindsey R. , deLeeuw Ronald J. , Savage Kerry J. , Rosenwald Andreas , Campo Elias , Delabie Jan , Ott German , Muller‐Hermelink Hans‐Konrad , Jaffe Elaine S. , Rimsza Lisa M. , Weisenburger Dennis D. , Chan Wing C. , Staudt Louis M. , Connors Joseph M. , Gascoyne Randy D. , Lam Wan L. 
Published: September 2007

AbstractPrimary mediastinal B‐cell lymphoma (PMBCL) is a distinct subtype of diffuse large B‐cell lymphoma. PMBCL has been previously studied with a variety of genomic techniques resulting in frequent detection of chromosomal gains; however, chromosomal losses have been rarely reported. This finding contrasts many other types of lymphoma, in which deletions are common. We hypothesize that segmental losses do exist but may have escaped detection by methods used in the previous studies. Using array comparative genomic hybridization to a tiling‐resolution microarray encompassing the entire human genome, PMBCL samples were analyzed for genomic copy number alterations. An almost equal number of gains and losses of chromosomal material were detected throughout the genome (216 vs. 193, respectively). A selection of these DNA copy number alterations were confirmed by quantitative real‐time PCR. Recurrent gains were detected at all previously reported regions of gain, including 9p seen in ∼70% of cases. Recurrent chromosomal losses were observed at 1p, 3p, 4q, 6q, 7p, and 17p, with a novel event at 1p13.1–p13.2 representing the most frequent at 42% of cases analyzed. We conclude that consistent losses are present in the PMBCL genome. Given the similar frequency of losses to that of segmental gains of DNA, they are likely to play an important role in the pathogenesis of PMBCL. © 2007 Wiley‐Liss, Inc.
ArrayCGH‐based classification of neuroblastoma into genomic subgroups
Authors: Michels Evi , Vandesompele Jo , De Preter Katleen , Hoebeeck Jasmien , Vermeulen Joëlle , Schramm Alexander , Molenaar Jan J. , Menten Björn , Marques Barbara , Stallings Raymond L. , Combaret Valérie , Devalck Christine , De Paepe Anne , Versteeg Rogier , Eggert Angelika , Laureys Geneviève , Van Roy Nadine , Speleman Frank 
Published: September 2007

AbstractHigh‐resolution array comparative genomic hybridization (arrayCGH) profiling was performed on 75 primary tumors and 29 cell lines to gain further insight into the genetic heterogeneity of neuroblastoma and to refine genomic subclassification. Using a novel data‐mining strategy, three major and two minor genomic subclasses were delineated. Eighty‐three percent of tumors could be assigned to the three major genomic subclasses, corresponding to the three known clinically and biologically relevant subsets in neuroblastoma. The remaining subclasses represented (1) tumors with no/few copy number alterations or an atypical pattern of aberrations and (2) tumors with 11q13 amplification. Inspection of individual arrayCGH profiles showed that recurrent genomic imbalances were not exclusively associated with a specific subclass. Of particular notice were tumors with numerical imbalances typically observed in subtype 1 neuroblastoma, in association with genomic features of subtype 2A or 2B. A search for prognostically relevant genomic alterations disclosed 1q gain as a predictive marker for therapy failure within the group of subtype 2A and 2B tumors. In cell lines, a high incidence of 6q loss was observed, with a 3.87–5.32 Mb region of common loss within 6q25.1–6q25.2. Our study clearly illustrates the importance of genomic profiling in relation to tumor behavior in neuroblastoma. We propose that genome‐wide assessment of copy number alterations should ideally be included in the genetic workup of neuroblastoma. Further multicentric studies on large tumor series are warranted in order to improve therapeutic stratification in conjunction with other features such as age at diagnosis, tumor stage, and gene expression signatures. © 2007 Wiley‐Liss, Inc.