bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanism of Shenfu Injection in Treating Ischemic Stroke Elucidated using Network Pharmacology and Experimental Validation
Authors: Yu Xuecheng , Shi Kun , Wu Bin , Gao Zengxiang , Tu Jiyuan , Cao Yan , Chen Linlin , Cao Guosheng 
Published: April 2024

Background:
Shenfu injection was derived from the classical Chinese medicine formula
‘Shenfu decoction’, which was widely used in the treatment of cardiovascular and cerebrovascular
diseases in clinical practice.

background:
Shenfu injection is derived from the classical Chinese medicine formula ‘shenfu decoction’, which is widely used in the treatment of cardiovascular and cerebrovascular diseases in clinical practice.

Objectives:
Predict the main active ingredients, core targets, and related signaling pathways of
Shenfu injection in the treatment of ischemic stroke.

objective:
Predicting the main active ingredients, core targets, and related signaling pathways of shenfu injection in the treatment of ischemic stroke.

Methods:
Databases were used to collect the active ingredients and target information of Shenfu
injection; GO and KEGG pathway enrichment analyses were performed using the David database.
The effects of Shenfu injection on core targets were verified using molecular docking and
in vivo experiments.

method:
Databases were used to collect the active ingredients and target information of shenfu injection; GO and KEGG pathway enrichment analysis were performed using David database.The effects of shenfu injection on core targets were verified using molecular docking and in vivo experiments.

Results:
The predicted results identified 44 active ingredients and 635 targets in Shenfu injection,
among which 418 targets, including TNF, IL-6, MAPK1, and MAPK14, were potential
targets for the treatment of ischemic stroke. Molecular docking revealed that the active ingredients
had good binding to IL-6, MAPK1, and MAPK14. In vivo experiments demonstrated that
Shenfu injection significantly improved the pathological damage due to ischemic stroke, promoted
the expression of tight junction proteins, and inhibited MMP-2 and MMP-9 expressions,
thereby reducing BBB permeability. Animal experiments revealed that Shenfu injection could
inhibit p38、JNK and ERK phosphorylation.

Conclusions:
Mechanism of Shenfu injection in treating ischemic stroke may be via inhibition
of the inflammatory factors levels and protecting the BBB, thereby warranting subsequent studies
and highlighting its potential as a reference for new drug development.
Decarbonizing the Transport of Microalgae-based Products —The Role of E-mobility
Authors: Dias Rosangela Rodrigues , Depra Mariany Costa , Carvalho Victor Cesar Rodrigues , de Menezes Cristiano Ragagnin , Zepka Leila Queiroz , Jacob-Lopes Eduardo 
Published: April 2024

Background:
The decarbonization of road transport is a precondition for
achieving carbon neutrality. Battery-electric vehicle technology, driven by several patents,
can make this a reality. In this bias, the objective of the article is to shed light on the ongoing
debate about the potentially important role of the adoption of electric vehicles in the
transport of microalgae-based products to help them advance to a cleaner life cycle.

Methods:
Five routes, including unimodal and multimodal conditions, were defined to
assess the carbon emissions of the transport system and, more specifically, of road
transport. The headquarters of market-leading microalgae manufacturers were selected as
the origin of the routes and, as the destination, regions that sustain them.

Results:
The results reveal the supremacy of road transport of microalgae-based products
using electric vehicles powered by nuclear, hydroelectric, and wind, followed by biomass
and photovoltaic energy. They also show that the positive impact of wind, water, and photovoltaic
energy on the climate, added to the lower battery charging costs and the greater
opportunity to generate revenue from the sale of carbon credits, make their trade-offs.

Conclusion:
The exquisite results of this study convey key messages to decision-makers
and stakeholders about the role of electromobility in building a zero-carbon delivery route.
Twitter Analysis of Health Care Workers’ Sentiment and Discourse Regarding Post–COVID-19 Condition in Children and Young People: Mixed Methods Study
Authors: Chepo Macarena , Martin Sam , Déom Noémie , Khalid Ahmad Firas , Vindrola-Padros Cecilia 
Published: April 2024

Background
The COVID-19 pandemic has had a significant global impact, with millions of cases and deaths. Research highlights the persistence of symptoms over time (post–COVID-19 condition), a situation of particular concern in children and young people with symptoms. Social media such as Twitter (subsequently rebranded as X) could provide valuable information on the impact of the post–COVID-19 condition on this demographic.

Objective
With a social media analysis of the discourse surrounding the prevalence of post–COVID-19 condition in children and young people, we aimed to explore the perceptions of health care workers (HCWs) concerning post–COVID-19 condition in children and young people in the United Kingdom between January 2021 and January 2022. This will allow us to contribute to the emerging knowledge on post–COVID-19 condition and identify critical areas and future directions for researchers and policy makers.

Methods
From a pragmatic paradigm, we used a mixed methods approach. Through discourse, keyword, sentiment, and image analyses, using Pulsar and InfraNodus, we analyzed the discourse about the experience of post–COVID-19 condition in children and young people in the United Kingdom shared on Twitter between January 1, 2021, and January 31, 2022, from a sample of HCWs with Twitter accounts whose biography identifies them as HCWs.

Results
We obtained 300,000 tweets, out of which (after filtering for relevant tweets) we performed an in-depth qualitative sample analysis of 2588 tweets. The HCWs were responsive to announcements issued by the authorities regarding the management of the COVID-19 pandemic in the United Kingdom. The most frequent sentiment expressed was negative. The main themes were uncertainty about the future, policies and regulations, managing and addressing the COVID-19 pandemic and post–COVID-19 condition in children and young people, vaccination, using Twitter to share scientific literature and management strategies, and clinical and personal experiences.

Conclusions
The perceptions described on Twitter by HCWs concerning the presence of the post–COVID-19 condition in children and young people appear to be a relevant and timely issue and responsive to the declarations and guidelines issued by health authorities over time. We recommend further support and training strategies for health workers and school staff regarding the manifestations and treatment of children and young people with post–COVID-19 condition.
Bayesian Networks for Prescreening in Depression: Algorithm Development and Validation
Authors: Maekawa Eduardo , Grua Eoin Martino , Nakamura Carina Akemi , Scazufca Marcia , Araya Ricardo , Peters Tim , van de Ven Pepijn 
Published: April 2024

Background
Identifying individuals with depressive symptomatology (DS) promptly and effectively is of paramount importance for providing timely treatment. Machine learning models have shown promise in this area; however, studies often fall short in demonstrating the practical benefits of using these models and fail to provide tangible real-world applications.

Objective
This study aims to establish a novel methodology for identifying individuals likely to exhibit DS, identify the most influential features in a more explainable way via probabilistic measures, and propose tools that can be used in real-world applications.

Methods
The study used 3 data sets: PROACTIVE, the Brazilian National Health Survey (Pesquisa Nacional de Saúde [PNS]) 2013, and PNS 2019, comprising sociodemographic and health-related features. A Bayesian network was used for feature selection. Selected features were then used to train machine learning models to predict DS, operationalized as a score of ≥10 on the 9-item Patient Health Questionnaire. The study also analyzed the impact of varying sensitivity rates on the reduction of screening interviews compared to a random approach.

Results
The methodology allows the users to make an informed trade-off among sensitivity, specificity, and a reduction in the number of interviews. At the thresholds of 0.444, 0.412, and 0.472, determined by maximizing the Youden index, the models achieved sensitivities of 0.717, 0.741, and 0.718, and specificities of 0.644, 0.737, and 0.766 for PROACTIVE, PNS 2013, and PNS 2019, respectively. The area under the receiver operating characteristic curve was 0.736, 0.801, and 0.809 for these 3 data sets, respectively. For the PROACTIVE data set, the most influential features identified were postural balance, shortness of breath, and how old people feel they are. In the PNS 2013 data set, the features were the ability to do usual activities, chest pain, sleep problems, and chronic back problems. The PNS 2019 data set shared 3 of the most influential features with the PNS 2013 data set. However, the difference was the replacement of chronic back problems with verbal abuse. It is important to note that the features contained in the PNS data sets differ from those found in the PROACTIVE data set. An empirical analysis demonstrated that using the proposed model led to a potential reduction in screening interviews of up to 52% while maintaining a sensitivity of 0.80.

Conclusions
This study developed a novel methodology for identifying individuals with DS, demonstrating the utility of using Bayesian networks to identify the most significant features. Moreover, this approach has the potential to substantially reduce the number of screening interviews while maintaining high sensitivity, thereby facilitating improved early identification and intervention strategies for individuals experiencing DS.
PENGEMBANGAN E-MODUL BERBASIS LITERASI DIGITAL BAHASA ARAB PADA MATERI JAM KELAS 8 DI MADRASAH TSANAWIYAH
Authors: Hasyim Muhammad Wahid , Astuty Indri , Enawaty Eny 
Published: April 2024

Abstract: This research aims to produce Arabic digital literacy-based e-modules on class 8 clock material at Madrasah Tsanwiyah. The research method used is the ADDIE model which is oriented towards a system approach through five stages. Research data sources. The sources of research data are interviews, questionnaires of validator assessments of material experts, instruments, media, design, language and questions. The results of the study were obtained from student response questionnaires. The developed teaching e-module consists of introduction, content and cover. The effectiveness results of the prestest and posttest scores show a significant difference obtained 𝑝 < 0.05, namely 0.001 < 0.05. As for the students' response is 3.6 from the maximum average of 4.00, it can be categorized as very to be able to conclude that teaching is effective e-modules based on Arabic digital literacy on the material of class 8 Clock of madrasah Tsanawiyah. Keywords: Development, E-Module, digital literacy, Clock Abstrak: Penelitian ini bertujuan untuk menghasilkan e-modul berbasis literasi digital bahasa Arab pada materi jam kelas 8 di Madtasah Stanawiyah. Metode penelitian yang digunakan yaitu model ADDIE yang berorientasi pada pendekatan sistem melalui lima tahap. Sumber data penelitian. Sumber data penelitian adalah wawancara, angket penilaian validator Ahli materi, instrument, media, desain, bahasa dan soal. Hasil penelitian didapat dari angket respon siswa. E-modul ajar yang dikembangkan terdiri pendahuluan, isi dan penutup. Hasil efektivitas dari nilai prestest dan posttest menunjukkan perbedaan signifikan diperoleh 𝑝 < 0.05, yaitu 0.001 < 0.05. Sedangkan untuk respon peserta didik adalah 3,6 dari rata-rata maksimal 4,00 dapat dikategorikan sangat sehingga dapat disimpulkan efektif e-modul ajar berbasis literasi digital bahasa arab pada materi jam kelas 8 madrasah Tsanawiyah. Kata Kunci: Pengembangan, E-Modul, Literasi digital, Cahaya dan Penglihatan
A tale of Two Schools
Authors: Rodriguez Cristian 
Published: April 2024

Digital devices and learners cannot be seen as separate entities but as a functional entanglement that come (and stay) together in a performative encounter in which they are mutually saturated with each other's agencies. This research intends to explore the nature of the entanglement between secondary school learners and their digital devices as well as the implications of this entanglement when theorising a framework for learning in secondary school. This presentation proposes a language and a series of metaphors to describe and understand why the integration of technology in the classroom seems to have failed to deliver the promised transformation.

From an enactive perspective, it primarily uses a mix of phenomenological and ethnographic methodology to analyse students’ experience of learning with digital devices. Whilst a micro-phenomenological approach attempted to explore the unfolding of particular experiences, a socio-material micro-ethnographic approach was used as a form of contrasting the phenomenological first-person account with a socio-technical analysis of the entanglement. .

Bio
Cristian Rodriguez is Deputy Principal at Whangaparāoa College, a secondary school in Auckland, New Zealand. His portfolios include Technology & Innovation and Future Learning Pathways. He has a background in education leadership, and a particular interest in change management, contemporary education and the future of schooling. Cristian is a final-year PhD Candidate at AUT. His thesis, ‘The Digital Entanglement: how students and devices come (and stay) together’, looks into the role of digital technologies in supporting cognitive processes in the context of secondary school. His work aims at creating a better understanding of the impact of design and adoption of digital technologies for learning in educational settings. Cristian’s areas of expertise include: Philosophy of Education, Embodied Cognition, Contemporary Education and Pedagogies, Culturally Responsive Pedagogy, Digital learning implementation, The digital as a structure of perception, and Microphenomenology.ResearchGate Profile & Linkedin Profile.
O plano nacional de educação em disputa no governo Lula
Authors: Trópia Patrícia Vieira 
Published: April 2024

Este ensaio tem por objetivo discutir o significado histórico e político do Plano Nacional de Educação, mais precisamente o processo de disputa em torno de sua implementação durante o governo Lula. Duas questões, em particular, mobilizam a análise: 1) a manutenção dos vetos, pelo governo Lula, ao projeto aprovado na Câmara (Lei nº 10.172/) e 2) o déficit entre as metas propostas e as alcançadas ao final de 2010. Quais seriam as razões para o primeiro governo do Partido dos Trabalhadores ter mantido os vetos?
Conferência nacional de educação 2010 e a construção do plano nacional de educação 2011-2021
Authors: Gorni Doralice Aparecida Paranzini 
Published: April 2024

O presente texto apresenta uma reflexão sobre em que medida a realização da Conferência Nacional de Educação 2010, com vistas à elaboração do Plano Nacional de Educação 2011/2020. Consiste em um sinal do aprimoramento do processo de democratização da sociedade brasileira e, em decorrência da sua educação, constitui um ensaio subsidiado no estudo e análise das políticas educacionais brasileiras, a partir do século passado, e de seus impactos sobre distintos cotidianos escolares. Para tanto, analisa brevemente alguns elementos presentes no seu desenvolvimento, no período em questão, com vistas a evidenciar que a educação brasileira encontra-se em um estágio em que se torna imprescindível a constituição do Sistema Nacional de Educação. A posição assumida pelo governo federal de coordenar o movimento nacional em prol da construção do novo Plano Nacional de Educação evidencia o reconhecimento deste fato. No entanto, permanece o desafio de garantia das condições necessárias para que este seja materializado nos distintos contextos escolares. Neste sentido, o documento final da Conferência Nacional de Educação 2010 renova as expectativas de que, na próxima década, a democratização da educação brasileira possa se consolidar como fato e não apenas como direito.
Health and older adults: stereotypes and objective indicators
Authors: Novoselova E. N. 
Published: April 2024

In the context of ageing, the problem of health among older adults needs special attention. The article attempts to analyze key health indicators among older people, their perception and acceptance of their own age, as well as the perception of them by others. The article also analyzes processes of inclusion of older people in the economic, social, and cultural life. Trying to determine the age boundaries of an old age, the author comes to the conclusion that it is impossible to identify a single correct classification, due to the heterogeneity of the “elderly” group, the discrepancy between their views on life, the difference in health status and their perceptions of illnesses. The analysis factors influencing this heterogeneity will help to understand the main problems of life expectancy and will make it possible to develop more effective programs to prolong a healthy lifestyle and active aging. The author analyzes such health indicators as: life expectancy, healthy life expectancy, self-assessment of health, social and medical literacy of the elderly population. The author does not ignore the COVID-19 pandemic, which had an impact on physical and mental health of older people, as they were the main risk group during the pandemic.The article is based on the results of the most significant and recent Russian and foreign works in the fields of sociology of ageing and sociology of health. The methodological basis of the work is a secondary analysis of research data from the Public Opinion Foundation (FOM), the All-Russian Center for the Study of Public Opinion (VTsIOM), etc.
Social phenomena of physical culture and sports through the eyes of young people
Authors: Belozerov V. I. 
Published: April 2024

This article is devoted to the study of social phenomena of physical culture and sports, as one of the significant and promising areas of modern sociological research. Starting with a reference to the understanding in Russian legislation of the content of the concepts of “physical culture” and “sport”, as well as their relationship with each other, the author of the article draws attention to the importance of studies of ideas about social phenomena of physical culture and sports that have developed among various groups of the population, in particular, among young people. To identify these ideas in youth, and above all, in its most active part – student youth from September 4 to 8, 2023, he conducted an author’s pilot empirical study “Social phenomena of physical culture and sports” among bachelor students of the sociological faculty of Moscow State University named after M.V. Lomonosov 1–3 courses in two areas of training – “Sociology”, as well as “Public policy and social sciences”. As part of this study, students were asked to answer blocks of questions aimed at identifying the motivation and involvement of student youth in physical education and sports. The author’s analysis of the results of the study showed that between physical education and sports, students of the sociological faculty of Moscow State University do not see much difference, actually identifying them, and more than half of students actually identify physical education with the discipline taught by him at the university. At the same time, the process of communication in virtual space (in networks, chats, blogs, etc.), communication with friends, as well as walks in the fresh air, for students of the sociological faculty of Moscow State University are more priority than the activities of physical education and sports themselves.
Understanding the essence of the “Great game” by representatives of Anglo-Saxon geopolitical schools
Authors: Elishev S. O. 
Published: April 2024

This article is devoted to understanding the essence of “The Great Game”, that is, the policy of containing the development of Russia by Anglo-Saxon elites and powers (dating back more than two centuries), representatives of Anglo-Saxon geopolitical thought. Perceiving Russia as the main obstacle to achieving its global geopolitical hegemony, Anglo-Saxon elites and powers actively waged large-scale diplomatic, economic, information wars and battles against Russia, military operations, conducted operations to organize coups d’etat and “revolutions”, trying to destroy Russia both by actions from outside and undermining it from within. Naturally, to justify this kind of policy, a certain ideological justification and information support was required, which were carried out in particular by English and American geopolitics. The author emphasizes that the ideological justification of the “Great Game” by Anglo-Saxon geopolitics began in the classical period of the development of geopolitics, a characteristic feature of which was the unlimited dominance of the ideas of geographical determinism, which interprets the entire course of the development of human civilization as fundamental geopolitical dualism – the confrontation between two different powerful types of human civilizations and states – the powers of the Sea (sea, colonial powers) and Land (continental, land powers). The author considers the geopolitical concepts of the founders of the American and English national schools of geopolitics – A.T. Mahan, J.H. McKinder, N. Spikeman, formulated the main ideas of Atlantism – the geopolitical theory and practice of the collective West, NATO member countries that assign a leading role in world history to maritime states and civilizations. Within the framework of the modern period of the development of Anglo-Saxon political thought (which is characterized by the development of geeconomic concepts and a civilizational approach), the author of the article analyzes the views of American globalist geopolitics – J. Kennan, G. Kissinger, F. Fukuyama, Zb. Brzezinski, S. Huntington, as well as one of the founders of the civilizational approach – the English historian A. Toynbee, as well as the concept of the “death of the West” P. Buchanan.