bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bio-agronomic and genetic variability of local lemon cultivars from Southern Italy
Authors: Smimmo Roberta , Cirillo Aurora , Di Serio Ermanno , Garramone Raffaele , Villano Clizia , Aversano Riccardo , Carputo Domenico , Di Vaio Claudio 
Published: February 2025

Abstract
In Italy, lemon is a crucial economic cultivation, primarily grown in southern regions like Sicily, Calabria, Apulia and Campania. Despite its importance, the number of cultivars is limited and efforts are being made to both exploit and preserve local cultivars. Bio-agronomic and genetic characterization are essential steps towards achieving these goals. Our study explores the phenotypic and genetic diversity of four local cultivars from Campania region, ‘Ovale di Sorrento’, ‘Sfusato Amalfitano’, ‘Procida’ and ‘San Francesco’, over two years (2021 and 2022). We evaluated agronomic parameters of the entire plant, fruits and seeds, and conducted biochemical analyses of lemon juice. Furthermore, we addressed the challenges posed by low interspecific genetic variation through simple sequence repeat (SSR) and single nucleotide polymorphism (SNP) marker analysis. Field data revealed significant differences in production between the two years and among the cultivars, with ‘Ovale di Sorrento’ and ‘Sfusato Amalfitano’ being the most productive, and ‘Procida’ recording the lowest values of soluble solids and acidity. Genotyping data from 19 SSR markers confirmed low variability, while ddRADSeq-based SNP analysis revealed clear structuration into three distinct groups: the first group comprised ‘Ovale di Sorrento’ and ‘San Francesco,’ differentiated from ‘Procida’ and ‘Sfusato Amalfitano’. Additionally, 29 high-effect variants provided valuable insights into the genetic distinctions and functional variations among the four lemon cultivars. In particular, the presence of variants in genes associated with mobile elements confirmed their significant contribution to the genetic diversity of plants. This study underscores the importance of combining phenotypic and genotypic analyses for better varietal characterization and valorization.
Unveiling the therapeutic potential of aromadendrin (AMD): a promising anti-inflammatory agent in the prevention of chronic diseases
Authors: El-Shiekh Riham A. , Radi Mai Hussin , Abdel-Sattar Essam 
Published: February 2025

Abstract
In the dynamic realm of scientific inquiry, the identification and characterization of biologically active compounds derived from plant extracts have become of utmost significance. A particularly noteworthy flavonoid in this regard is aromadendrin (AMD), which can be found in a diverse range of foods, fruits, plants, and natural sources. The versatility of this compound is evident through its wide array of biological properties, including its well-documented anti-inflammatory, antioxidant, antidiabetic, neuroprotective, immunomodulatory, cardioprotective, and hepatoprotective effects. These diverse actions validate its potential utilization in addressing drug-related side effects, adverse reactions, neoplasms, ulcers, jaundice, diabetes mellitus, dermatitis, neurodegenerative diseases, cognitive disorders, polyploidy, carcinomas, common colds, and cumulative trauma disorders. This review aims to unlock the full potential of AMD and pave the way for groundbreaking advancements in the fields of medicine and nutrition. Prepare to embark on an enthralling journey as we unveil the hidden treasures and extraordinary prospects associated with AMD.
Becoming Similar, but Drifting Apart: Partnerships Between Universities and Public Research Organizations
Authors: Thune Taran , Borlaug Siri Brorstad 
Published: February 2025

Abstract
Many national research and innovation systems include higher education institutions and public research organizations (PRO) with different mandates and tasks. This paper investigates what happens to the relationship between a university and a PRO when they are increasingly pushed towards fulfilling similar tasks and functions. We investigate this through a historical case study of the relationship between a university and a PRO within the field of science and technology and draw on concepts from the institutional logics and institutional complexity literatures to frame the study. We find that in the early phase of the relationship, institutional complexity was handled through a strategy of “structural differentiation” where the university outsourced the commercial logic to the PRO, but in practice the two operated as integrated organizations. In the later phases, growing external demands and internal developments led to a “blending” strategy where the university reincorporated the commercial science logic. This had a fundamental impact on the relationship between the two organizations in terms of increased competition and blurring of roles, which led to increased structural and operational separation. Our study underlines the importance of considering wider, and often unintended, ramifications of policies on the research and innovation system as a whole.
An automated approach for difference detection in cultural heritage applications
Authors: Saiti Evdokia , Saha Sunita , Bunsch Eryk , Sitnik Robert , Theoharis Theoharis 
Published: February 2025

Abstract
This paper presents the application of two key stages in Cultural Heritage (CH) analysis: cross-time registration and change detection, aimed at automatically identifying subtle geometric variations in CH objects. The proposed method addresses the challenge of manually aligning and detecting differences among large collections of 3D-digitized objects, which is both time-consuming and error-prone. The method combines CrossTimeReg deep learning technique for automatic registration and the Change-Based-Segmentation method for identifying differences and segmented changes. We applied this method to two ceramic sculptures, titled Zephyr and Flora, from the Museum of King Jan III’s Palace at Wilanów, Poland, and validated the results with the CH scientific experts of the museum. The results demonstrated that our method effectively detected geometric variations resulting from potential alterations or restorations, which are crucial for verifying the authenticity of artifacts. Additionally, the method facilitated comparative analysis, enabling researchers to examine similar objects and establish connections, origins, and historical significance. The technique also proved useful in analyzing changes in the geometry of the same object over time due to destructive factors.
Good enough? A comparison of different harmonization procedures and their substantive consequences using the example of life satisfaction
Authors: Heizmann Boris 
Published: February 2025

Abstract
Survey data harmonization can greatly improve the analytical potentials of survey data by making divergent measurements of the same construct comparable. While there may often be ideas on what is the optimal harmonization strategy (e.g. imputation or equipercentile equating), these approaches are not always feasible e.g. due to data-based restrictions or the lack of a suitable reference sample. Therefore, sometimes there is only a set of second-best strategies, such as linear equating or linear stretching, with no clear idea which of these should be given preference. The present paper takes this situation as a starting point and investigates the substantive consequences of different alternatives for a typical harmonization scenario using real-world survey data. Divergent substantive consequences are understood as differences in obtained analytical result patterns. Do the actual scientific conclusions differ when different harmonization approaches are employed? Results based on a variety of regression scenarios indicate that most substantive conclusions are obtained regardless of the harmonization approach chosen, but that harmonization procedures entailing an information loss due to recoding variables into smaller sets of categories should be avoided. Overall, this suggests that research based on sub-optimally harmonized scales can also yield valid scientific insights.
Writing and iconicity in The Idiot: towards Dostoevsky’ s graphopoetics
Authors: Horváth Géza 
Published: February 2025

Abstract
Dostoevsky’s discourse in The Idiot is aimed—and this is his main artistic task—at developing the artistic language of a previously unknown world, of the singular human experience unfolding within the novel, rather than at conveying a finished, completed plot. The focus of this paper is on the process of constructing this new symbolic language of self-understanding, which can be approached through an analysis of the unique interplay of textuality, visuality and corporeality in this novel and in the genre of the modern novel. This paper shall examine the crucial role played by Dostoevsky’s drawings and calligraphy in the poetics of The Idiot in the context of the genesis of this novel, in order to show that the “ideograms” that appear in sketches and drafts are saturated with metaphorical meaning and thus become text- and plot-forming motifs and discursive signs. This new discourse of the novel incorporates several other literary works at the level of intertextuality (specifically Cervantes’ Don Quixote and Victor Hugo’s novel The Last Day of the Condemned Man), and in this way recalls the genre specificity of the modern novel and the creative processes of text and plot creation.
Under pressure? Exploring the moderating and mediating role of principal–teacher relationships in primary and secondary school teachers’ burnout symptoms
Authors: Dehne Mathias , Roorda Debora L. , Koomen Helma M. Y. , Zee Marjolein 
Published: February 2025

Abstract
Identifying protective factors against increased work pressure is crucial to prevent teachers from experiencing burnout complaints. Two studies with 363 primary (Study 1; 95.0% female) and 419 secondary school teachers (Study 2; 80.4% female) tested whether dyad-level principal–teacher relationships (closeness, conflict) moderated or mediated the associations between work pressure and burnout symptoms. In both studies, closeness and conflict partially mediated the association of work pressure with emotional exhaustion and depersonalization. Closeness fully (Study 1) or partially (Study 2) mediated the association with personal accomplishment. However, no evidence for a moderating role was found. To conclude, principal–teacher relationships seem to be a potential mechanism underlying the association between work pressure and burnout.
Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of Alzheimer´s Disease
Authors: Mengr Anna , Šmotková Zuzana , Pačesová Andrea , Železná Blanka , Kuneš Jaroslav , Maletínská Lenka 
Published: February 2025

Abstract
Alzheimer’s disease (AD) is the most common form of dementia. Characterized by progressive neurodegeneration, AD typically begins with mild cognitive decline escalating to severe impairment in communication and responsiveness. It primarily affects cerebral regions responsible for cognition, memory, and language processing, significantly impeding the functional independence of patients. With nearly 50 million dementia cases worldwide, a number expected to triple by 2050, the need for effective treatments is more urgent than ever. Recent insights into the association between obesity, type 2 diabetes mellitus, and neurodegenerative disorders have led to the development of promising treatments involving antidiabetic and anti-obesity agents. One such novel promising candidate for addressing AD pathology is a lipidized analogue of anorexigenic peptide called prolactin-releasing peptide (palm11-PrRP31). Interestingly, anorexigenic and orexigenic peptides have opposite effects on food intake regulation, however, both types exhibit neuroprotective properties. Recent studies have also identified ghrelin, an orexigenic peptide, as a potential neuroprotective agent. Hence, we employed both anorexigenic and orexigenic compounds to investigate the common mechanisms underpinning their neuroprotective effects in a triple transgenic mouse model of AD (3xTg-AD mouse model) combining amyloid-beta (Aβ) pathology and Tau pathology, two hallmarks of AD. We treated 3xTg-AD mice for 4 months with two stable lipidized anorexigenic peptide analogues – palm11-PrRP31, and liraglutide, a glucagon-like peptide 1 (GLP-1) analogue – as well as Dpr3-ghrelin, a stable analogue of the orexigenic peptide ghrelin, and using the method of immunohistochemistry and western blot demonstrate the effects of these compounds on the development of AD-like pathology in the brain. Palm11-PrRP31, Dpr3-ghrelin, and liraglutide reduced intraneuronal deposits of Aβ plaque load in the hippocampi and amygdalae of 3xTg-AD mice. Palm11-PrRP31 and Dpr3-ghrelin reduced microgliosis in the hippocampi, amygdalae, and cortices of 3xTg-AD mice. Palm11-PrRP31 and liraglutide reduced astrocytosis in the amygdalae of 3xTg-AD mice. We propose that these peptides are involved in reducing inflammation, a common mechanism underlying their therapeutic effects. This is the first study to demonstrate improvements in AD pathology following the administration of both orexigenic and anorexigenic compounds, highlighting the therapeutic potential of food intake-regulating peptides in neurodegenerative disorders.

Graphical Abstract
Current Approaches of Pancreatic Cancer Surveillance in High-Risk Individuals
Authors: Heller Melissa , Mann Derek A. , Katona Bryson W. 
Published: February 2025

Abstract
Currently, those recommended to undergo pancreatic cancer (PC) surveillance include appropriately aged individuals at high risk of PC due to an identifiable genetic susceptibility or those without identifiable genetic susceptibility who nonetheless have a strong family history of PC. With increases in identification of individuals at high risk for PC and increased use of PC surveillance in clinical practice, there has been increasing debate about who should undergo surveillance as well as how surveillance should be performed including use of imaging and blood-based testing. Furthermore, there is increasing interest in the outcomes of PC surveillance in high-risk individuals with some studies demonstrating that surveillance leads to downstaging of PC and improvements in survival. In this review, we summarize the current state of PC surveillance in high-risk individuals, providing an overview of the risk factors associated with PC, selection of high-risk individuals for PC surveillance, and the current, but non-uniform, recommendations for performing PC surveillance. Additionally, we review approaches to apply various imaging and blood-based tests to surveillance and the outcomes of PC surveillance.
The Right to Food in Question: A Comparative Analysis of Food Security Policies Aimed at the Elderly in Spain and Argentina
Authors: Gracia-Arnaiz Mabel , Demonte Flavia , Boragnio Aldana 
Published: February 2025

Abstract
Since the 2008 economic recession, and in the wake of the health and energy crises, many countries have experienced growing precarization, forcing their governments to implement policies to alleviate increasing inequality suffered by the most disadvantaged groups. In this study, we show how this process has affected older people in Spain and Argentina. In particular, we want to determine whether there has been an increase in food insecurity (FI) during this period in two countries that, on paper, recognise the fundamental right of everyone to enjoy adequate food in all its dimensions and also have specific plans for active and healthy ageing. Based on a compilation and comparative analysis of socio-demographic, food and health indicators and policies/programmes targeted at this age group, we describe the profile and main needs of older people, as well as the mechanisms in place to guarantee (or not) this right. We discuss the different conceptions of food security in the two countries, along with the nature and scope of the measures adopted. We conclude that although food security (FS) policies are very different in Spain and Argentina, what they have in common is the absence and/or insufficiency of specific mechanisms for identifying the impact of growing precarization on food practices and health, and those most affected in terms of gender, social class or ethnic origin. We highlight the need to develop intersectional studies capable of diagnosing and detecting FI situations among older people and counteracting possible forms of ageism arising from this lack of knowledge.
Mentalization, theory of mind and socioemotional development in middle childhood
Authors: Locati Francesca , Federica Conte , Karin Ensink , Nick Midgley , Laura Parolin 
Published: February 2025

Abstract
Theory of Mind (ToM) and Mentalization are essential domains involved in child socioemotional development. ToM is the ability to understand people’s actions and interactions as guided by internal beliefs, emotions, desires, and intentions. In contrast, mentalization is a mental process involved in interpreting human behaviour in terms of mental states related to the self and others. ToM and mentalization constructs are frequently used interchangeably, although they play distinct roles in child development. The present study explores this issue, focusing on the mentalization and ToM interactive dynamics in relation to middle childhood socioemotional skills. Participants were 112 non-clinical children from 8 to 10 y.o. assessed with Child Reflective Functioning Scale (CRFS) on Child Attachment Interview, Reading the Mind in the Eyes test and the Roberts-2 Test. Results from network analysis revealed an association between ToM and Mentalization. Mentalization is positively connected with self-help abilities and age. ToM supports mentalization, while mentalization is related to developing a sense of self-agency involved in improving psychological resources and preventing mental health impairment.
Protocol for Returning Results in Brain Science Research Targeting Individuals With Neurodevelopmental Disorders in Japan
Authors: YANO Koji , YASUMURA Akira , TAKIMOTO Yoshiyuki 
Published: February 2025

Abstract
Brain science research targeting neurodevelopmental disorders has rapidly advanced in recent years. Although findings from these studies could potentially serve as objective indicators for future screening and diagnosis, researchers may encounter ethical challenges when returning results to participants and their legal guardians, such as family members. Furthermore, no established guidelines exists for returning results in this field, either in Japan or internationally. This study aimed to identify the ethical considerations associated with returning results in brain science research on neurodevelopmental disorders and to develop a protocol for doing so. The authors held regular meetings to discuss ethical issues and conducted a comprehensive search for relevant guidelines and literature. Databases such as PubMed, Igaku Chuo Zasshi, CiNii, and Google Scholar were searched for prior studies. Additionally, we referenced and manually searched genetic research literature and guidelines, as ethical considerations related to returning results in genetic and brain science research share commonalities, and the former has already advanced discussions on these issues. Key ethical concerns identified include the certainty of the results, the psychological burden of returning results, and the decision-making process. Researchers should verify the accuracy of results and, based on this, decide whether and how to return them. It is crucial to tailor explanations to the unique characteristics of neurodevelopmental disorders. Moreover, supporting participants in making autonomous decisions while respecting the authority of their legal guardians is essential.
Kinetic Modeling of Thermophilic Anaerobic Digestion of Lemnaceae for Biogas Production
Authors: Lower Lillian , Qiu Yaojing , Sartor Ryan C. , Sagues William Joe , Cheng Jay J. 
Published: February 2025

Abstract
Anaerobic digestion of sustainably sourced biomass to generate biogas is a vital form of renewable energy that provides significant benefits to the environment. Lemnaceae, commonly referred to as duckweed, has shown great potential as a next-generation biomass feedstock for anaerobic digestion due to its rapid growth rates, low lignin content, and ability to remove nutrients from wastewater. However, research in this area is largely focused on the mesophilic (35 °C) anaerobic digestion of duckweed. For the first time, batch thermophilic anaerobic digestion was performed using three different duckweed varieties grown on swine lagoon wastewater to ascertain the biochemical methane potential (BMP) of the biomasses and estimate parameters associated with the kinetics of the digestion process. The BMPs of the three duckweed varieties were 205 ± 5, 217 ± 5, and 262 ± 7 mL CH4 g−1 volatile solids (VS) for the local variety (OxNC), Lemna gibba (8678), and Lemna gibba (7741), respectively. Four kinetic models were fitted to the experimental data: first order, modified Gompertz, transference, and logistic function. Unique to this study, inoculum from continuous thermophilic anaerobic digesters processing identical feedstocks was used during the BMP, causing the absence of a lag phase. The first-order model predicted the hydrolysis constant (k) to be 0.205–0.285 day−1, which is similar to the hydrolysis constants reported in the literature for effective anaerobic digestion systems, thereby demonstrating that duckweed biomass has viable degradation rates. In this work, BMP experimentation and kinetic modeling have demonstrated the viability of anaerobically digesting multiple varieties of duckweed biomass under thermophilic conditions.
Initial experience with a virtual atrial fibrillation clinic after pulmonary vein isolation using follow-up with photoplethysmography
Authors: Reijrink-de Boer Melanie , Wolsink Iris , Frenaij Irene , Beukema Kasper F. , Brouns Berber , van Dijk Vincent F. , Liebregts Max , Wijffels Maurits C. E. F. , Boersma Lucas V. A. , Balt Jippe C. 
Published: February 2025

Abstract

Background
To detect recurrent atrial fibrillation (AF) after pulmonary vein isolation (PVI), different methods can be used, ranging from incidental electrocardiograms (ECGs) to rhythm monitoring with implantable loop recorders. We investigated whether telemonitoring (TM) with photoplethysmography (PPG) is feasible for post-PVI follow-up.

Methods
In total, 157 pre-PVI patients were included. Of them, 78 underwent TM at a virtual AF clinic, for which they received a PPG application and were monitored by trained eNurses. The numbers of hospital contacts, hospital visits, ECGs and Holter recordings were assessed. Patient satisfaction and quality of life were analysed. Comparisons were made with a historical control group with a traditional follow-up of outpatient visits, ECGs and Holter recordings (n = 79).

Results
Mean ± standard deviation (SD) age was 63 ± 10 years, and 64% were male. AF was paroxysmal in 68% of the patients. Follow-up at 1 year was completed in all patients. In the TM group, the mean ± SD annual number of recordings per patient was 16 ± 29, and AF was detected in 37 patients (47%). The TM group experienced significant decreases in the numbers of unplanned outpatient clinic visits and AF-related hospital admissions, as well as reductions in the numbers of ECGs and Holter recordings performed. Patients reported high satisfaction with this form of TM.

Conclusion
The use of a virtual AF clinic was feasible, and satisfaction was high. Compared with patients with a traditional follow-up, patients on PPG-based TM needed fewer hospital visits and admissions and underwent fewer ECGs and Holter recordings.