bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rationally designed catalytic nanoplatform for enhanced chemoimmunotherapy via deploying endogenous plus exogenous copper and remodeling tumor microenvironment
Authors: Sun Daxi , Yu Liting , Wang Gang , Xu Yuxue , Wang Peng , Wang Ningning , Wu Zhengyan , Zhang Guilong , Zhang Jia , Zhang Yunjiao , Tian Geng , Wei Pengfei 
Published: February 2024

Abstract

Chemodynamic therapy represents a novel tumor therapeutic modality via triggering catalytic reactions in tumors to yield highly toxic reactive oxygen species (ROS). Nevertheless, low efficiency catalytic ability, potential systemic toxicity and inefficient tumor targeting, have hindered the efficacy of chemodynamic therapy. Herein, a rationally designed catalytic nanoplatform, composed of folate acid conjugated liposomes loaded with copper peroxide (CP) and chloroquine (CQ; a clinical drug) (denoted as CC@LPF), could power maximal tumor cytotoxicity, mechanistically via maneuvering endogenous and exogenous copper for a highly efficient catalytic reaction. Despite a massive autophagosome accumulation elicited by CP-powered autophagic initiation and CQ-induced autolysosomal blockage, the robust ROS, but not aberrant autophagy, underlies the synergistic tumor inhibition. Otherwise, this combined mode also elicits an early onset, above all, long-term high-level existence of immunogenic cell death markers, associated with ROS and aberrant autophagy -triggered endoplasmic reticulum stress. Besides, CC@LPF, with tumor targeting capability and selective tumor cytotoxicity, could elicit intratumor MHC-II positive dendritic cells (mainly attributed to CQ) and tumor infiltrating CD8 positive T cells, upon combining with PD-L1 therapeutic antibody, induce significant anti-tumor effect. Collectively, the rationally designed nanoplatform, CC@LPF, could enhance tumor chemoimmunotherapy via deploying endogenous plus exogenous copper and remodeling tumor microenvironment.
Incorrect and incomplete distribution data can mislead species modeling: a case study of the endangered Litsea auriculata (Lauraceae)
Authors: Tan Chao , Ferguson David Kay , Yang Yong 
Published: February 2024

Abstract
Global warming has caused many species to become endangered or even extinct. Describing and predicting how species will respond to global warming is one of the hot topics in the field of biodiversity research. Species distribution modeling predicts the potential distribution of species based on species occurrence records. However, it remains ambiguous how the accuracy of the distribution data impacts on the prediction results. To address this question, we used the endangered plant species Litsea auriculata (Lauraceae) as a case study. By collecting and assembling six different datasets of Litsea auriculata, we used MaxEnt model to perform species distribution modeling and then conducted comparative analyses. The results show that the distribution of Litsea auriculata is mainly in the Dabie Mountain region, southwestern Hubei and northern Zhejiang, and that mean diurnal temperature range (bio2) and temperature annual range (bio7) play important roles in the distribution of Litsea auriculata. Compared with the correct data, the dataset including misidentified specimens leads to a larger and expanded range in the predicted distribution area, whereas the species modeling based on the correct but incomplete data predicts a smaller and contracted range. According to the analysis of the local protection status of Litsea auriculata, we found that only about 23.38% of this species is located within nature reserves, so there is a large conservation gap. Our study suggests that the accurate distribution data is important for species modeling, and incomplete and incorrect data normally gives rise to misleading prediction results. In addition, our study also revealed the distribution characteristics and conservation gaps of Litsea auriculata, laying the foundation for the development of rational conservation strategies for this species.
Volatility and Risk – Median Shortfall or Value at Risk
Authors: Ditlhong Kago 
Published: February 2024

Abstract
The value-at-risk (VaR) is a widely used risk measure by financial institutions and regulators even though it fails to capture risk at the tail end. The purpose of this research is to contribute to the ongoing discourse on risk management by assessing the median shortfall (MS) as an alternative risk measure by comparing it with the VaR. We investigate the performance of VaR forecasts considering the following models: historical simulation (HS) and Glosten-Jagannathan-Runkle-generalized autoregressive conditional heteroscedasticity (GJR-GARCH). For MS forecasts, we consider only the HS. The comparison was based on an accuracy test and loss function on the following stock indices: the S&P 500, the Russell 2000 small cap and the DAX (Germany) from January 1, 2006, to December 31, 2020. Empirical analysis indicated the superiority of the MS approach in capturing tail risk for the overall testing period. In addition to the aforementioned findings, there was a gain in using the GJR-GARCH(1, 1) VaR in capturing tail risk, especially in turbulent periods.
Influence of sludge deposit layer on sludge treatment reed beds treating septage
Authors: Huong Yu Zhe , Tan Yee Yong , Tang Fu Ee , Saptoro Agus 
Published: February 2024

Abstract
There is a lack of study on the influence of the sludge deposit layer on the performance of sludge treatment reed beds (STRBs) treating septage as well as the sludge deposit characteristics due to the operational parameters of solids loading rate (SLR) and resting periods. The laboratory-scale STRB was operated under varying SLRs and resting periods to investigate the sludge deposit characteristics, dewatering efficiency, and the quality of the rejected water. Inadequate operation, such as excessive loading and insufficient resting period, resulted in prolonged surface ponding, and the total solids (TS) content failed to meet the disposal standard of 20%. This study found that the STRB operated with 100 kg/m2/year SLR and 6-day resting period performed the best in sludge dewatering and stabilization, as the final TS content and total volatile solids/TS ratio of the sludge deposit were 23 and 33%, respectively. Meanwhile, the moisture content always remained higher than the plastic limit, preventing severe surface cracking that led to poor rejected water quality. In addition, the average COD and TS removals in the rejected water from all STRBs reached 96 and 88%, respectively, revealing that the proposed system is promising and reliable in treating septage.
Digital Smoking Cessation Intervention for Cancer Survivors: Analysis of Predictors and Moderators of Engagement and Outcome Alongside a Randomized Controlled Trial
Authors: Andree Rosa , Mujcic Ajla , den Hollander Wouter , van Laar Margriet , Boon Brigitte , Engels Rutger , Blankers Matthijs 
Published: February 2024

Background
Recent studies have shown positive, though small, clinical effects of digital smoking cessation (SC) interventions for cancer survivors. However, research on associations among participant characteristics, intervention engagement, and outcomes is limited.

Objective
This study aimed to explore the predictors and moderators of engagement and outcome of MyCourse-Quit Smoking (in Dutch: “MijnKoers-Stoppen met Roken”), a digital minimally guided intervention for cancer survivors.

Methods
A secondary analysis of data from the randomized controlled trial was performed. The number of cigarettes smoked in the past 7 days at 6-month follow-up was the primary outcome measure. We analyzed interactions among participant characteristics (11 variables), intervention engagement (3 variables), and outcome using robust linear (mixed) modeling.

Results
In total, 165 participants were included in this study. Female participants accessed the intervention less often than male participants (B=–11.12; P=.004). A higher Alcohol Use Disorders Identification Test score at baseline was associated with a significantly higher number of logins (B=1.10; P<.001) and diary registrations (B=1.29; P<.001). A higher Fagerström Test for Nicotine Dependence score at baseline in the intervention group was associated with a significantly larger reduction in tobacco use after 6 months (B=–9.86; P=.002). No other associations and no moderating effects were found.

Conclusions
Overall, a limited number of associations was found between participant characteristics, engagement, and outcome, except for gender, problematic alcohol use, and nicotine dependence. Future studies are needed to shed light on how this knowledge can be used to improve the effects of digital SC programs for cancer survivors.

Trial Registration
Netherlands Trial register NTR6011/NL5434; https://onderzoekmetmensen.nl/nl/trial/22832
The Effect of Various Concentrations of Both Lime Juice and Synthetic Citric Acid Solutions to Protect Capsicum frutescens L. against Yellow Leaf Curl Disease
Authors: Wagiman Rejo , Agus Yohanes Hendro , Simanjuntak Bistok Hasiholan 
Published: February 2024

The yellow leaf curl (YLC) disease is one of plant disease generally found in chili pepper. The aim of the research was to know various concentrations of lime juice and synthetic citric acids to protect chili pepper (Capsicum frutescens L.) against YLC disease. The research used a randomized completely block design using seven treatments and three replications. The treatments tested were spraying lime juice of 0.1%, 0.2%, and 0.3% volume per volume (v/v); citric acid solution of 0.1%, 0.2%, and 0.3 % weight per volume (w/v). Control was used water only. The data result were analyzed using the honestly significant different test at the 95% confidence level. The treatment of both lime juice and citric acid solutions 0.2% and 0.3% could decreased whitefly population on chili pepper compared with control. The lime juice and citric acid solutions 0.3% was able to reduce the incidence and intensity of YLC disease. Lime juice and citric acid solution of 0.2% and 0.3% increased fruit numbers and fruit weights compared with control. The lower whitefly population decreased disease incidence of YLC (with regression Y = 5.7505x – 48.029). Intensity of YLC disease decreased fruit numbers and fruit weight (correlation value of -0.949 and -0.912). Keywords: Citric acid, Chili pepper, Gemini virus diseases, Whitefly.
DOM HELDER CAMARA E OS MOVIMENTOS DEFENSORES DOS DIREITOS HUMANOS (1968-1977)
Authors: Silva Rosildo Henrique 
Published: February 2024

Este trabalho vem analisar as ações de dom Helder como denunciador das violações dos direitos humanos no período da ditadura civil-militar e também evidenciar os seus movimentos de transformação das estruturas sociais, focado no amor, justiça e paz, são eles: a Ação, Justiça e Paz-AJP, as Minorias Abraâmicas e a Comissão de Justiça e Paz-CJP. Esses Movimentos são de suma importância na atualidade para refletir sobre Minorias que pensam em transformar os pensamentos discriminatórias. O objetivo é averiguar a trajetória de Helder Camara em favor de um mundo de justiça e paz sem discriminação e prioritariamente transmitindo respeito à pessoa humana. A pesquisa é qualitativa baseada nas Cartas Circulares e nos discursos de Helder Camara. Portanto, dom Helder é declarado como patrono brasileiro dos direitos humanos onde lutou contra todas as formas de desrespeito ao ser humano.
INCIDÊNCIA DA HIPERTENSÃO E DIABETES MELLITUS JUNTO A POPULAÇÃO IDOSA E O PAPEL DA POLÍTICA DE SAÚDE DIANTE DA REALIDADE BRASILEIRA
Authors: Nicacio de Melo Vanda , Carvalho Chaves Anderson , Rodrigues Gaspar Elaine 
Published: February 2024

Diante do fator envelhecimento mostra-se a relevância deste tema, apresentando o processo e conquistas dos direitos dos idosos e os desafios frente a sua efetivação, contudo, esses direitos conquistados estão em risco com os desmontes das política públicas, tendo na atualidade o novo modelo capitalista que busca o lucro, mediante a reestruturação produtiva e globalizada, através da flexibilização e da privatização, desencadeando a perca dos direitos sociais, causando o desemprego, a precarização do trabalho e da saúde, tais fatores influenciam diretamente na saúde dos idosos, desencadeando diversas doenças crônicas, entre elas a hipertensão e diabetes mellitus. A presente pesquisa objetivou revisar a literatura sobre os direitos do idoso com diagnostico de HAS e DM e as políticas públicas de saúde na atualidade. Tratou-se de uma revisão bibliográfica de característica exploratória e descritiva, de cunho qualitativo, com base de pesquisa a partir de fontes impressas e eletrônicas. Também foi utilizada a plataforma online Google Acadêmico. Resultados: Os resultados foram expostos a partir da construção de reflexões sobre a Incidência da ipertensão e diabetes mellitus junto a população idosa e a política de saúde diante da ealidade brasileira, com destaque na política de saúde e no envelhecimento, ligado ao contexto político que transcorrem no desenvolvimento da saúde no Brasil. Estratégias que visam apoiar as políticas públicas na área da saúde são fundamentais para uma mudança no contexto social diante da complexidade do tema abordado. Foi possível identificar a importância da informação e educação em saúde. Orientar os indivíduos através de políticas de promoção de saúde, para que sejam capazes de conhecer a doença, a fim de que cooperando com as medidas de autocuidado e com a prevenção, sejam evitados o surgimento de complicações associadas as doenças crônicas não transmissíveis se tornam uma ação imprescindível.
ANÁLISE DAS TIPOLOGIAS DE VIOLÊNCIA
Authors: Santos Rocha Marleide , Araujo da Fonseca Tatiana Maria 
Published: February 2024

A Proteção Social Especial – PSE de Média Complexidade organiza a oferta de serviços, programas e projetos de caráter especializado que requerem maior estruturação técnica e operativa, com competências e atribuições definidas, destinados ao atendimento a famílias e indivíduos em situação de risco pessoal e social, por violação de direitos.
A Assistência Social busca o enfrentamento da violência como um componente de proteção e bem estar social.
Subcutaneous administration of ceftazidime at 20 and 40 mg/kg produces theoretically therapeutic plasma concentrations for at least 120 hours in red-eared sliders (Trachemys scripta elegans)
Authors: Hiebert Kara , Cox Sherry , Hawkins Shawna 
Published: February 2024

Abstract

OBJECTIVE
To evaluate and compare the pharmacokinetic parameters of SC ceftazidime administered at 20 and 40 mg/kg to red-eared sliders.

ANIMALS
8 adult red-eared sliders (Trachemys scripta elegans).

METHODS
In a sequential, 2-period study with a 3-week washout period between treatments, ceftazidime was administered SC to turtles at 20 and 40 mg/kg. Blood samples were collected from the subcarapacial sinus at 0, 24, 48, 72, 96, and 120 hours after ceftazidime administration. Plasma ceftazidime concentrations were quantified using reversed-phase HPLC.

RESULTS
Mean plasma half-life after 20- and 40-mg/kg dosing was 39.75 ± 8.0 hours and 33.03 ± 6.56 hours, respectively. Mean maximum plasma concentration after 20- and 40-mg/kg dosing was 71.0 ± 15.93 µg/mL and 120.0 ± 30.62 µg/mL, respectively. Mean plasma ceftazidime concentrations remained ≥ 8 µg/mL, the theoretical MIC for various reptile pathogens for all time points.

CLINICAL RELEVANCE
Results indicate that ceftazidime dosed at either 20 or 40 mg/kg produces plasma concentrations exceeding the theoretical MIC of various reptile pathogens for at least 120 hours. An ideal dosing interval could not be determined, as all plasma concentrations remained above the threshold of interest for all time points. Follow-up studies should focus on establishing a dosing interval and more rigorous monitoring for potential adverse effects.
Propolis (Bee Glue): A Promising Natural Feed Additive for Poultry and Rabbits – A Review
Authors: Abd El-Ghany Wafaa A. 
Published: February 2024

Abstract
The concerns about the possible adverse effects of synthetic feed additives in livestock production world-wide has led producers to search for alternative natural feed additives. Propolis (bee glue) is a mixture of natural viscous substances that are collected by honeybees from plants. This natural product consists of about 200–300 compounds with high biological and pharmacological properties. Propolis induces an improvement in growth parameters, feed utilization, and meat quality. It also exerts antioxidant, anti-stress, antimicrobial, anti-inflammatory as well as immuno-modulatory and hepatic and cardiac protective effects. The presence of a huge amount of polyphenols such as flavonoids, phenolic acid esters, triterpenes, aromatic acids, diterpenic acids, and lignans are responsible for the biological properties of propolis. Therefore, propolis shows potential promising effects when applied in livestock and poultry production system. Accordingly, this review article is aimed to highlight the influences of propolis on the general health conditions of poultry and rabbits regarding the performance parameters and carcass characteristics, as well as the antioxidant, anti-stress, anti-microbial, anti-inflammatory, and the immuno-potentiation potentials.
Effect of Vitamin D3 on Uterine Morphology and Insulin Signaling in a Polycystic Ovary Syndrome (PCOS) Rat Model
Authors: Kamińska Kinga , Tchurzyk Marcelina , Fraczek Olga , Szlaga Agata , Sambak Patryk , Tott Szymon , Małek Kamilla , Knapczyk-Stwora Katarzyna , Błasiak Anna , Rak Agnieszka , Grzesiak Małgorzata 
Published: February 2024

Abstract
Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women of reproductive age leading to infertility. Besides reproductive and hormonal disturbances, PCOS is often characterized by vitamin D3 (VD) deficiency. This study aimed to determine the effect of VD on uterine histoarchitecture, the biochemical composition of gland secretions, and the insulin signal transduction pathway using a PCOS rat model. The experiment was conducted on four animal groups (n=8/group): control (C), VD supplemented (VD; 500 IU/day), letrozole-treated (PCOS; 1 mg/kg body weight), and VD-treated PCOS (PCOS+VD) group. Herein, VD supplementation did not improve histomorphometric parameters in the PCOS uterus, whereas clearly influenced sugar composition in uterine gland secretions, restoring their content to that observed in the C group. Furthermore, we found that VD can reduce peripheral and local uterine insulin resistance developed in the PCOS rats via activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway and subsequent glucose metabolism in the uterus. To sum up, the present results suggest a possible beneficial role of VD supplementation for the maintenance of uterus functions in PCOS rats.
Cooperative Power Domain Noma Transmission Using Relays
Authors: Ligwa Mario , Balyan Vipin 
Published: February 2024

Abstract
The non-orthogonal multiple access (NOMA) multiple access technique, due to its non-orthogonality and providing access to users together, which have the same frequency and time resource, made it a front runner to meet the need of high traffic requirements networks. In this paper, a downlink, NOMA, and cooperative NOMA (CNOMA) are compared with varying different parameters: source transmit power, user transmit power, and power allocation for achievable sum rates. Simulation results show that the CNOMA achieves a higher sum rate as compared to NOMA for all the parameters.
دور بعض خصائص المعلومات في العملية الإنتاجية دراسة مسحية في معمل سمنت بادوش/التوسيع
Authors: اليوزبكي بسام عبدالرحمن , سالم محمد ثامر 
Published: February 2024

يهدف البحث إلى استكشاف دور كل من دقة المعلومات وموثوقيتها في العملية الإنتاجية في معمل سمنت بادوش/التوسيع. وتتمثل المشكلة البحثية بعدم وضوح الدور الذي تؤديه خصائص المعلومات المتاحة للمستفيدين في ممارسة العملية الإنتاجية، وقد تم اختيار دقة المعلومات وموثوقيتها بوصفهما من أهم وأبرز خصائص المعلومات، واستناداً إلى ذلك فقد تم صياغة مشكلة البحث بالتساؤل الآتي: هل تسهم دقة المعلومات وموثوقيتها في تحسين العملية الإنتاجية في المعمل المبحوث؟
وبهدف تحقيق ذلك فقد تم اختيار عينة عشوائية من الموظفين في المعمل بوصفهم أفراداً يزاولون دوراً يتمثل باستخدام خصائص المعلومات في تنفيذ العملية الإنتاجية في المعمل المبحوث، وقد استخدمت استمارة الاستبانة بوصفها الأداة الرئيسة في الحصول على البيانات، وقد تم استخدام عدد من الأساليب الاحصائية لاختبار الفرضيات عن طريق البرنامج الاحصائي (SPSS20). وقد توصل البحث إلى عدد من النتائج كان من أبرزها وجود تأثير إحصائي ذو دلالة معنوية لكل من دقة المعلومات وموثوقيتها في العملية الإنتاجية.
مدى إسهام التوجه التسويقي في تعزيز تبني التسويق الأخضر دراسة تحليلية لآراء عينة من العاملين في مصنع ألبان الموصل
Authors: حامد الملاحسن محمد محمود , عبدالمجيد عمر سالم 
Published: February 2024

هدف هذا البحث إلى بيان مدى اسهام التوجه التسويقي في تعزيز التسويق الأخضر في مصنع البان الموصل وكذلك توضيح علاقات الارتباط والاثر بين المتغيرين، وقد اعتمد البحث على محورين اساسيين تمثل الاول بكونه وثائقي وصفي متمثلا بالاطلاع على عدد من الأدبيّات لتوضيح الخلفية النظرية لكل من التوجه التسويقي والتسويق الأخضر التي عرضها الكتاب والباحثين في نتاجاتهم العلمية. أما الأسلوب الثاني فهو أسلوب استطلاعي تحليلي، من خلال اعداد استمارة استبانة اعدت لغرض جمع البيانات والمعلومات المتعلقة بالبحث، وسعى الباحثان إلى تضمين عدد من الأسئلة المعبرة عن مشكلة البحث التي كانت الاساس لمنهجية البحث والاعتماد عليها في الجانب الميداني وكان اهمها التساؤل الرئيسي: ما طبيعة الأثر للتوجه التسويقي في التسويق الأخضر في المنظمة المبحوثة، وللإجابة على هذا السؤال تمت صياغة مخطط فرضي للبحث يعكس من خلاله العلاقات والتأثيرات بين متغيري البحث، مما نتجت عنه مجموعة من الفرضيات الرئيسة والفرعية التي اختبرت باستخدام عددٍ من الوسائل الإحصائية للبيانات التي جمعت بالاستبانة التي وزعت على (59) فردا مبحوثا في المنظمة المبحوثة والتي تمثلت في مصنع البان الموصل، وتوصل البحث إلى مجموعة من الاستنتاجات التي يعرض الباحث أهمها:

افصحت نتائج اختبار الفرضية الرئيسة الاولى عن وجود اسهام للتوجه التسويقي في تعزيز تبني المنظمة المبحوثة للتسويق الأخضر كما افصحت نتائج اختبار الفرضية الرئيسة الثانية وفرعياتها علاقات ارتباط بين متغير التوجه التسويقي ومتغير التسويق الأخضر وهذا يدل على مدى الاهمية التي يتمتع بها متغيري الدراسة بالنسبة للمنظمة المبحوثة.
اظهرت نتائج اختبار الفرضية الرئيسة الثالثة عن وجود علاقات تأثير بين المتغيرات التي تبنتها الدراسة وهذا ما يعزز ما تم التوصل اليه في ضوء نتائج الفرضية الرئيسة الاولى.

وعلى ضوء ذلك قدم الباحثان جملة من المقترحات التي تخدم موضوع البحث.
وصف وتشخيص أبعاد المهارات الناعمة في جامعة الموصل دراسة استطلاعية لآراء عينة من التدريسين العاملين في الكليات الإنسانية
Authors: حميد رنا خيرالدين , الخشاب حسان ثابت 
Published: February 2024

يهدف البحث الحالي الى معرفة ابعاد المهارات الناعمة بين عينة من تدريسي جامعة الموصل، ولتحقيق هدف البحث فقد تم استخدام المنهج الوصفي التحليلي لجمع وتحليل البيانات الموزعة بواسطة استمارة الاستبانة وهي اداة البحث الرئيسة، وقد تم اختيار مجموعة من الكليات الانسانية متمثلة بـ (كلية الآداب، كلية التربية للعلوم الإنسانية، كلية التربية البدنية وعلوم الرياضة، كلية العلوم السياسية، كلية القانون، كلية الآثار، كلية الفنون الجميلة، كلية المعلمين)، وتم تحديد مجتمع البحث بمجموعة من العاملين في هذه الكليات وقد تم اختيار عينة قصدية بواقع (350) تدريسي تم توزيع استمارة الاستبانة عليهم، ولقد توصل البحث الى مجموعة من الاستنتاجات منها امتلاك اعضاء الهيئة التدريسية في الجامعة المبحوثة ابعاد المهارات الناعمة، وان ابعاد المهارات الناعمة تتباين من حيث اهميتها النسبية في الجامعة المبحوثة.
واستناداً الى ما تم التوصل اليه من نتائج فقد تم صياغة مجموعة من التوصيات كان من اهمها التعاون مع المنظمات الجامعية والاكاديمية في تطوير المهارات الناعمة لدى العاملين واشاعة مفهومها لأنها مازالت مفهوماً حديثاً نسبياً بحاجة إلى توضيح أبعاده وأهميته في العمل، اضافة الى العمل على عقد الورشات واللقاءات لتزويد العاملين بالمفاهيم الصحيحة لدور المهارات الناعمة في تحسين مستويات الاداء بشكل عام، ووضع سياسات وقوانين يتم الاستناد عليها في عمليات التوظيف تعتمد على مدى توافر المهارات الناعمة لدى المتقدمين للتوظيف والتشغيل في المنظمات.