bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higher Eccentric Hamstring Muscle Fatigue After Participation in a Soccer Match in Young Female Athletes
Authors: Nutarelli Sebastiano , Rocchi Jacopo Emanuele , Salerno Manuela , Sangiorgio Alessandro , Deabate Luca , Filardo Giuseppe 
Published: February 2024

Background: Hamstring (HS) strength deficits and imbalances have been identified as risk factors for sustaining anterior cruciate ligament (ACL) injuries and muscular strains, with HS injuries being the most prevalent muscle injuries in soccer athletes. The aim of this study was to investigate HS eccentric strength before and after a soccer match in both male and female soccer athletes. Hypothesis: Soccer athletes have changes in eccentric HS strength after a soccer game. Study Design: Cohort observational study. Level of Evidence: Level 3. Methods: HS eccentric strength (mean and absolute peak torque and total work) was measured in 64 healthy male and female competitive football athletes (14-25 years) with an automatic device during the execution of the Nordic hamstring exercise (NHE) test before and after a 90-minute soccer match. The anterior-knee laxity (AKL) was quantified with an arthrometer. Results: Mean and absolute eccentric HS peak torque decreased by 24.5 N.m (-12.34%; P < 0.01) and 21.9 N.m (-10.08%; P < 0.01) in female athletes, whereas their male peers improved by 19.9 N.m (+9.01%; P = 0.01) and by 20.9 N.m (+8.51%; P = 0.02), respectively. HS total work in female athletes decreased by 831.1 J ( P < 0.01) compared with the male athlete reduction of 235.3 J. Both the pre- versus postmatch intersex mean and absolute eccentric HS peak torque changes were significant ( P < 0.01), as were the changes in HS total work ( P < 0.01). The pre- versus postmatch AKL difference and the dominant versus nondominant limb comparison of the strength parameters were not significantly different. Younger female athletes (14-19 years old) presented a greater decrease in mean and absolute peak HS eccentric strength compared with those in older female athletes and men. Conclusion: HS eccentric strength and work differ based on athlete sex, as measured by the NHE test. Mean peak, absolute peak, and total work showed greater reductions in female athletes than those in their male peers. The subgroup of 14- to 19-year-old female athletes experienced the highest reduction in strength parameters.
Real-world safety and effectiveness of secukinumab in adult patients with moderate to severe plaque psoriasis: results from postmarketing surveillance in Korea
Authors: Kim Byung Soo , Kim Dong Hyun , Shin Bong Seok , Lee Eun-So , Jo Seong Jin , Bang Chul Hwan , Yun Yeojun , Choe Yong Beom 
Published: February 2024

Background: Secukinumab, a fully human monoclonal antibody, was approved in Korea for the treatment of moderate to severe psoriasis in September 2015. Objectives: To assess the safety and effectiveness of secukinumab in patients with moderate to severe psoriasis in Korea. Design: Multicenter, real-world, noninterventional study conducted over 6 years. Methods: Adults with moderate to severe psoriasis were enrolled. Safety was assessed by evaluating adverse events (AEs), treatment-related AEs, and serious AEs (SAEs). Effectiveness was assessed using the change in absolute Psoriasis Area and Severity Index (PASI) score, percentage of patients achieving PASI 75/90/100 and PASI ⩽2; at weeks 12 and 24. Results: Overall, 829 and 542 patients were included in the safety and effectiveness sets, respectively. AEs, treatment-related AEs, and SAEs occurred in 29.0%, 9.5%, and 4.1% of patients, with incidence rates of 39.43, 12.98, and 5.59 per 100 patient years, respectively. The absolute PASI score decreased from 16.1 ± 7.1 (baseline) to 1.6 ± 2.4 (week 24), with a similar reduction in biologic-naïve (16.4 ± 7.3 to 1.5 ± 2.2) and biologic-experienced (14.8 ± 5.9 to 2.4 ± 3.2) groups. At week 24, PASI 75/90/100 was achieved by 95.1%, 62.4%, and 24.9% of patients. At week 24, PASI 75/90 were higher in biologic-naïve (96.6%/65.8%) than biologic-experienced patients (88.3%/48.6%), whereas PASI 100 was similar in both cohorts (24.1% and 28.6%). A similar trend in PASI ⩽ 2 was observed in both cohorts. Conclusion: Secukinumab showed sustained effectiveness and favorable safety profile in adult patients with moderate to severe psoriasis in Korea.
Assessment of clinical pharmacist interventions using a web-based application in a Saudi Arabian Tertiary Hospital
Authors: AlKhanbashi Rana Omar , AlNoamy Yahya , Ghandorah Reham , Awan Razan Mohammed , AlButi Hala 
Published: February 2024

Objectives: Medication-related problems are a top concern of clinical pharmacists. Medication-related problems can cause patient harm and increase the number of visits, hospital admissions, and length of hospital stay. The objective was to assess clinical pharmacy medication-related problem-related interventions in a tertiary care setting. Methods: A retrospective cohort study was conducted at King Fahad Armed Forces Hospital in Jeddah (Saudi Arabia) between June 2021 and June 2022. The data were extracted monthly from a new web-based Microsoft Excel application documenting medication-related problems during any stage of the medication use process. Results: A total of 5310 medication-related problem-related interventions in 1494 patients were performed. The departments associated with the highest frequency of medication-related problem-related interventions were the critical care unit (26.9%), intensive care unit (23.8%), anticoagulation clinic (17.1%), medical ward (11.3%), and nephrology unit (6.8%). The most common type of medication-related problem-related interventions included inappropriate dosage regimens (25.6%), monitoring drug effect or therapeutic drug monitoring (24.4%), requirement of additional drug therapy (21.9%), and inappropriate drug selection (14.1%). The proposed interventions were accepted by physicians in 97% of the incidents. The most frequent medication classes associated with medication-related problem-related interventions were cardiovascular agents (47.6%), antimicrobial agents (27.2%), and nutrition and blood substitute agents (11.4%). The most frequent medication groups associated with medication-related problem-related interventions were anticoagulants (25.6%) and antibiotics (25.2%). Conclusions: The current findings characterize the medication-related problem-related interventions addressed in clinical pharmacy at a tertiary care setting. The high rate of physician acceptance emphasizes the integral patient safety role of clinical pharmacy services.
Effects of a Faith-Based Obesity Intervention on African American and Latino Adults’ Children
Authors: Perez Lilian G. , Flόrez Karen R. , Seelam Rachana , Williams Malcolm V. , Derose Kathryn P. 
Published: February 2024

Background Faith-based interventions are promising for promoting healthy behaviors among adults, but their ripple effects on participants’ children are unknown. This study is one of the first to assess the effects of a faith-based multilevel obesity intervention on adult participants’ children. Methods We analyzed quantitative data from a cluster randomized controlled trial with two African American and two Latino churches in South Los Angeles, California, which invited adult participants to enroll one child (5-17 years) in a sub-study. At baseline and 6-7 months follow-up, parents completed a child health survey, which included the family nutrition and physical activity screening tool, and child height and weight were measured ( n = 50). Results Results from linear regression models showed children of intervention participants, compared to control, had significantly better dietary patterns at follow-up. Conclusions Findings suggest the health benefits of a faith-based multilevel obesity intervention for adults can extend to children and may help address obesity disparities.
Demographics and clinical characteristics of carbon monoxide poisoning for patients attending in the emergency department at a tertiary hospital in Riyadh, Saudi Arabia
Authors: Alharthy Nesrin , Alanazi Aljohara , Almoqaytib Alreem , Alharbi Bedour , Alshaibani Rakad , Albuniyan Jawaher , Alshibani Abdullah 
Published: February 2024

Abstract
Background
Carbon Monoxide (CO) is one of the most common environmental causes of acute intoxication globally. It can lead to the development of Delayed Neuropsychiatric Sequelae (DNS) which may develop in 2-40 days after remission of acute CO poisoning. DNS is defined by recurrent-transient neurological, cognitive, or psychological manifestations. This study was intended to describe the demographics and characteristics of CO poisoning patients attending at the Emergency Department (ED) and assess the association between CO intoxication and the development of DNS in a tertiary hospital, Riyadh, Saudi Arabia.

Methods
A retrospective descriptive cross-sectional study was conducted in subjects who were diagnosed with CO poisoning and attended to the ED at King Abdulaziz Medical City (KAMC) and King Abdullah Specialist Children’s Hospital (KASCH) in Riyadh during the period from January 2016 to December 2021. Patient demographics, vitals, diagnostic tests, and oxygen therapy at initial presentation were documented. Patient medical records were reviewed at 2-40 days following CO poisoning for development of DNS. Ethical approval was obtained from King Abdullah International Medical Research Center (KAIMRC).

Results
A total of 85 patients were diagnosed with CO poisoning and met the study inclusion criteria. Of those, 76% were adults with an average age of 32.36 (SD ± 15.20) and 51% were male adults. Five (6%) of the 85 patients developed DNS. Common symptoms included dizziness, nausea, and decreased visual acuity in 40% of the cases. The development of DNS manifestations was most likely (80%) to occur at 2 to 10 days after the initial incident. Inferential statistics showed that BMI (p-value = 0.021) and age group (p-value = 0.029) were significantly associated with COHb level, which was not the case for gender and the presence of clinical manifestation. Furthermore, Gender was significantly associated with the development of DNS (20% male vs. 80% female, p = 0.050).

Conclusions
The findings of this study are consistent with previous published studies showing low proportions of patients who were exposed to CO poisoning at risk of developing DNS. Further larger-scale multicenter studies are needed to assess the factors associated with the development of DNS for patients with CO poisoning.
Impact of teaching on use of mechanical chest compression devices: a simulation-based trial
Authors: Steffen Richard , Burri Simon , Roten Fredy-Michel , Huber Markus , Knapp Jürgen 
Published: February 2024

Abstract
Background
The use of mechanical chest compression devices on patients in cardiac arrest has not shown benefits in previous trials. This is surprising, given that these devices can deliver consistently high-quality chest compressions without interruption. It is possible that this discrepancy is due to the no-flow time (NFT) during the application of the device. In this study, we aimed to demonstrate a reduction in no-flow time during cardiopulmonary resuscitation (CPR) with mechanical chest compression devices following 10 min of structured training in novices.

Methods
270 medical students were recruited for the study. The participants were divided as a convenience sample into two groups. Both groups were instructed in how to use the device according to the manufacturer’s specifications. The control group trained in teams of three, according to their own needs, to familiarise themselves with the device. The intervention group received 10 min of structured team training, also in teams of three. The participants then had to go through a CPR scenario in an ad-hoc team of three, in order to evaluate the training effect.

Results
The median NFT was 26.0 s (IQR: 20.0–30.0) in the intervention group and 37.0 s (IQR: 29.0–42.0) in the control group (p < 0.001). In a follow-up examination of the intervention group four months after the training, the NFT was 34.5 s (IQR: 24.0–45.8). This represented a significant deterioration (p = 0.015) and was at the same level as the control group immediately after training (p = 0.650). The position of the compression stamp did not differ significantly between the groups. Groups that lifted the manikin to position the backboard achieved an NFT of 35.0 s (IQR: 27.5–42.0), compared to 41.0 s (IQR: 36.5–50.5) for the groups that turned the manikin to the side (p = 0.074).

Conclusions
This simulation-based study demonstrated that structured training can significantly reduce the no-flow time when using mechanical resuscitation devices, even in ad-hoc teams. However, this benefit seems to be short-lived: after four months no effect could be detected.
Optimization and characterization of quercetin-loaded solid lipid nanoparticles for biomedical application in colorectal cancer
Authors: Mohamed Jamal Moideen Muthu , Ahmad Fazil , El-Sherbiny Mohamed , Al Mohaini Mohammed Ahmad , Venkatesan Krishnaraju , Alrashdi Yahya Bin Abdullah , Eldesoqui Mamdouh Basheir , Ibrahim Adel Ehab , Dawood Amal Fahmy , Ibrahim Ateya Megahed , El Deeb Sami 
Published: February 2024

Abstract
Background
Colorectal cancer (CRC) is a type of cancer that affects the colon or rectum and occurs in individuals over the age of 50, although it can affect people of all ages. Quercetin is a flavonoid, which is a type of plant pigment with antioxidant and anti-inflammatory properties. Some studies have explored the potential of quercetin as an adjuvant therapy to enhance the effectiveness of chemotherapy or radiation therapy.

Methodology
In the proposed work, the nano-biomaterials of solid lipids such as stearic acid (SA) and tripalmitin (TpN) as well as the surfactants tween 80 and span 80 were used to prepare novel quercetin (QuR)-loaded-solid lipid nanoparticles (QuR-SLNs) for medical applications in colorectal cancer (CRC). The resulting bio-nano SLNs’ mean entrapment efficiency (EE) and particle size (PS) were optimized by Box–Behnken design (BBD) approach based on the response-like surface methodology (RSM). The variables include lipid ratio (X1), surfactant ratio (X2), QuR-to-lipid ratio (X3), the sonication time (X4), and the homogenization time (X5). Requirements on the maximum EE (%) and minimum PS (nm) were optimized for the preparation of QuR-SLN. Differential scanning calorimetry (DSC), X-ray diffraction (XRD) analysis, and scanning electron microscopy (SEM) were then used to analyze the optimized SLN and to find the crystalline state of QuR with lipid relationship. In addition, on the Caco-2 cells, at IC50 (49 µM/mL), in vitro cytotoxicity was attained.

Results
The optimized QuR-SLN had practically spherical shapes, with % EE and a PS of 97.8 ± 1.16% and 132.16 ± 4.1 nm, respectively. In aqueous media, the degree of lipid crystallinity and the lipid modification was investigated, and the QuR incorporation and release patterns showed high correlations with both. The results showed that over 41.12 ± 1.6% of the bio-nano QuR-SLNs was released gradually over the course of 48 h, demonstrating effective QuR delayed release. Results on apoptotic observations indicate that apoptosis accounts for the majority of cell death, while necrosis, a type of cell death, constitutes a very minor portion. In conclusion, the prepared bio-nano QuR-SLNs might improve cytotoxicity and can act as an ideal carrier for the delivery of QuR and this preparation is used in the treatment of CRC.
Effect of deficit irrigation combined with Bacillus simplex on water use efficiency and growth parameters of maize during vegetative stage
Authors: Nawaz Haq , Akgün İlknur , Şenyiğit Ulaş 
Published: February 2024

AbstractThe production of crops depending on many factors including water, nutrient, soil types, climate and crops types, water stress and drought is in one of the important factors affecting crop productivity. The experiment was conducted in pots to evaluate the effect of biofertilizers (Bacillus simplex) with deficit irrigations on the early development and growth of maize crop under greenhouse condition. Pre sowing seed was inoculated with strain of bacteria (B+/B-) and different irrigation levels (no stress: 100% (I1) and deficit irrigation: 75 (I2), 50 (I3), 25 (I4) % of required water amount to reach pot capacity) was performed. Data was collected on different morphological characteristics and root characteristic of maize crop. Highest plant height (125 cm), stem diameter (18.02 mm), leaf area (350 cm− 2), plant weight (180.42 g in fresh, 73.58 g in dry), root length (92.83 cm) root ((91.70 g in fresh, (28.66 g in dry) weight were recorded in pots applied with 100% irrigation followed by 75%. Bacillus treated plants showed significant increase in leaf area (214.20 cm− 2), plant fresh weight (91.65 g) and dry weight (42.05 g), root length (79.20 cm), root fresh (53.52 g) and dry weight (16.70 g) compared with control (without bacteria). Likewise highest relative water content of leaf was observed with I3 followed by I2 and I1 respectively. Highest water use efficiency was recorded as 0.67 g pot− 1 mm− 1 in I1 with B + treatment. Likewise, Bacillus inoculated pots resulted in increased water use efficiency (0.44 g pot− 1 mm− 1) compared with no application (0.36 g pot− 1 mm− 1). It can be endorsed from the outcome that Bacillus inoculation increased plant biomass, root biomass of maize and water use efficiency during early growth stage of maize despite of water stress and can be used under limited water condition for crop combating during moderate to lower stress conditions.
Effect of carboxymethyl cellulose and gibberellic acid-enriched biochar on osmotic stress tolerance in cotton
Authors: Qian Lisheng , Huang Shoucheng , Song Zhihua , Fahad Shah , Dawar Khadim , Danish Subhan , Saif Hina , Shahzad Khurram , Ansari Mohammad Javed , Salmen Saleh H. 
Published: February 2024

AbstractThe deleterious impact of osmotic stress, induced by water deficit in arid and semi-arid regions, poses a formidable challenge to cotton production. To protect cotton farming in dry areas, it’s crucial to create strong plans to increase soil water and reduce stress on plants. The carboxymethyl cellulose (CMC), gibberellic acid (GA3) and biochar (BC) are individually found effective in mitigating osmotic stress. However, combine effect of CMC and GA3 with biochar on drought mitigation is still not studied in depth. The present study was carried out using a combination of GA3 and CMC with BC as amendments on cotton plants subjected to osmotic stress levels of 70 (70 OS) and 40 (40 OS). There were five treatment groups, namely: control (0% CMC-BC and 0% GA3-BC), 0.4%CMC-BC, 0.4%GA3-BC, 0.8%CMC-BC, and 0.8%GA3-BC. Each treatment was replicated five times with a completely randomized design (CRD). The results revealed that 0.8 GA3-BC led to increase in cotton shoot fresh weight (99.95%), shoot dry weight (95.70%), root fresh weight (73.13%), and root dry weight (95.74%) compared to the control group under osmotic stress. There was a significant enhancement in cotton chlorophyll a (23.77%), chlorophyll b (70.44%), and total chlorophyll (35.44%), the photosynthetic rate (90.77%), transpiration rate (174.44%), and internal CO2 concentration (57.99%) compared to the control group under the 40 OS stress. Thus 0.8GA3-BC can be potential amendment for reducing osmotic stress in cotton cultivation, enhancing agricultural resilience and productivity.
Angiographic characteristics of coronary artery disease in patients undergoing diagnostic coronary angiography at a tertiary hospital in Tanzania
Authors: Meda John R. , Kusima Happiness L. , Magitta Ng’weina F. 
Published: February 2024

Abstract
Background
Coronary artery disease (CAD) is an important cause of global burden of disease. There is a paucity of data on the burden and risk factors for CAD in sub-Saharan Africa (SSA), despite the rising trends in the shared risk factors across regions. The recent introduction of cardiac catheterization laboratory services in SSA could shed light on the burden of CAD in the region. We aimed to assess the angiographic characteristics among patients undergoing diagnostic coronary angiography (CAG) at a single tertiary care hospital in Tanzania.

Methods
This study was a retrospective chart review. A total of 728 patients  ≥ 18 years of age who underwent CAG from January 2020 to December 2022 were recruited into the study. Basic demographic variables, risk factors and clinical characteristics including CAG findings were obtained from the registry. In addition, CAG images were retrieved for assessment of angiographic features. The luminal vessel stenosis was assessed based on eyeballing and the degree of obstruction was agreed by two independent and experienced cardiologists. The coronary stenosis of ≥ 50% was considered significant for obstructive CAD. The study was approved by the local ethics committee.

Results
Of patients who were recruited into the study, 384 (52.23%) were female. The study participants had a mean age of 59.46 ± 10.83 standard deviation (SD) and mean body mass index (BMI) of 31.18 kg/m2. The prevalence of CAD of any degree was estimated at 24.43% (34.18% in male, 15.50% in female), while that of obstructive CAD was 18.27%. Forty six percent of those with obstructive CAD had multiple vessel disease (MVD). Nearly 77% of patients were found to have ≥ 50–70% luminal stenosis and while those with ≥ 70% luminal coronary artery stenosis constituted 56.65%. Right coronary artery (RCA) was the most commonly affected vessel, accounting for 36.84% when any vessel disease or 56% when single vessel disease were considered. Being 65 years or older and comorbidity with type 2 diabetes (T2D) were independent risk factors for developing CAD.

Conclusion
There is a high prevalence of obstructive CAD among patients undergoing diagnostic CAG in Tanzania, with male gender preponderance and increasingly higher in older age, often with severe disease. A large, prospective study is needed to provide epidemiological and clinical data for developing a locally-relevant cardio-preventive strategy for CAD intervention in Tanzania.