bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic approaches for spinal synovial sarcoma: a comprehensive review of the literature
Authors: Zamarud Aroosa , Shahnoor Syeda , Maryyum Adeena , Khan Abdul Moiz , Hassan Khawaja Muthammir , Ijaz Aamna , Sayed Rahman , Yoo Kelly , Park David J. , Chang Steven D. 
Published: March 2024

OBJECTIVE
Synovial sarcoma (SS) is a relatively rare type of soft-tissue sarcoma that is commonly treated with surgery, radiation, chemotherapy, and palliative care. Stereotactic radiosurgery (SRS) is an emerging approach that shows promise in treating CNS conditions, but it has not been studied for SS. The authors present a systematic review that explores the effectiveness of different treatments, with a focus on SRS, for managing spinal SS.

METHODS
A systematic PubMed search was conducted that covered studies from 1964 to 2022, yielding 70 relevant studies. Inclusion criteria encompassed primary and metastatic spinal SS, various treatment modalities, patient age 17 years or older, English-language studies, retrospective series, and case reports. Based on these criteria, 26 studies were included in this review and 44 were excluded.

RESULTS
Of the included studies, 15 patients from 9 studies were treated with surgical intervention followed by both conventional radiotherapy (RT) and chemotherapy, 10 patients from 10 studies were treated with surgery followed by RT, 5 studies comprising 8 patients were exclusively treated with surgery, 5 cases in 3 studies were treated with surgery plus concomitant chemotherapy, 4 patients in 2 studies were treated with SRS, and only 1 study reported treatment without surgery and with chemotherapy and RT. The median progression-free survival and overall survival periods observed in the SRS-treated patients were 37 months and 60 months, respectively, which were higher than those of any other treatment method or combination used.

CONCLUSIONS
The authors’ study offers a thorough review of spinal SS treatments. They are hopeful that this will aid clinicians in informed decision-making for better patient outcomes.
Clinical criteria for filum terminale resection in occult tethered cord syndrome
Authors: Klinge Petra M. , Leary Owen P. , Allen Philip A. , Svokos Konstantina , Sullivan Patricia , Brinker Thomas , Gokaslan Ziya L. 
Published: March 2024

OBJECTIVE
Tethered cord syndrome (TCS) comprises three symptom categories: back/leg pain, bowel/bladder, and neurological complaints. MRI typically reveals a low-lying conus medullaris, filum terminale (FT) pathology, or lumbosacral abnormalities. FT resection is established in TCS but not in radiologically occult TCS (OTCS). This study aims to identify patients with OTCS who are likely to benefit from FT resection.

METHODS
The authors recruited 149 patients with OTCS (31 pediatric, 118 adult) treated with FT resection—including only cases with progressive TCS, negative spine MRI, and no concurrent neurological/urological conditions. A comprehensive questionnaire collected patient self-reported symptoms and clinical findings at the preoperative and at 3- and 12-month follow-up examinations. Based on questionnaire data, the authors extracted a 15-item symptoms and findings scale to represent the three TCS symptom categories, assigning 1 point for each item present.

RESULTS
OTCS presents without radicular/segmental sensorimotor findings, but with leg/back pain and conus dysfunction, in addition to leg fatigue and spasticity; the latter indicating an upper motoneuron pathology. The 15-item scale showed clinical improvement in 89% of patients at the 3-month follow-up and 68% at the 12-month follow-up. Multivariate analysis of the scale revealed that it accurately predicts outcome of FT resection in 82% of cases. Patients with a preoperative score exceeding 6 points are most likely to benefit from surgery.

CONCLUSIONS
By applying the study’s inclusion criteria and incorporating the novel 15-item scale, surgeons can effectively select candidates for FT resection in patients with OTCS. The observed outcomes in these selected patients are comparable to those achieved in degenerative spine surgery.
Comparison of multilevel low-grade techniques versus three-column osteotomies in adult spinal deformity surgery: does harmonious correction matter?
Authors: Passias Peter G. , Williamson Tyler K. , Mir Jamshaid M. , Lebovic Jordan A. , Dave Pooja , Tretiakov Peter S. , Joujon-Roche Rachel , Imbo Bailey , Krol Oscar , Owusu-Sarpong Stephane , Vira Shaleen , Schoenfeld Andrew J. , Daniels Alan H. , Diebo Bassel G. , Lafage Renaud , Lafage Virginie 
Published: March 2024

OBJECTIVE
Recent debate has arisen between whether to use a three-column osteotomy (3CO) or multilevel low-grade (MLG) techniques to treat severe sagittal malalignment in adult spinal deformity (ASD) surgery. The goal of this study was to compare the outcomes of 3CO and MLG techniques performed in corrective surgeries for ASD.

METHODS
ASD patients who had a baseline PI-LL > 30° and 2-year follow-up data were included. Patients underwent either 3CO or MLG (thoracolumbar posterior column osteotomies at ≥ 3 levels or anterior lumbar interbody fusion at ≥ 3 levels with no 3CO). The segmental utility ratio was used to assess relative segmental correction (segmental correction divided by overall correction in lordosis divided by the number of thoracolumbar interventions [interbody fusion, thoracolumbar posterior column osteotomies, and 3CO]). The paired t-test was used to assess lordotic distribution by differences in lordosis between adjacent lumbar disc spaces (e.g., L1–2 to L2–3). Multivariate analysis, controlling for age, sex, BMI, osteoporosis, baseline pelvic incidence, and T1 pelvic angle, was used to evaluate the complication rates and radiographic and patient-reported outcomes between the groups.

RESULTS
A total of 93 patients were included, 53% of whom underwent MLG and 47% of whom underwent 3CO. The MLG group had a lower BMI (p < 0.05). MLG patients received fewer previous fusions than 3CO patients (31% vs 80%, p < 0.001). MLG patients had 24% less blood loss but a 22% longer operative time (565 vs 419 minutes, p = 0.008). Using adjusted analysis, the 3CO group had greater segmental and relative correction at each level (segmental utility ratio mean 69% for 3CO vs 23% for MLG, p < 0.001). However, the 3CO group had lordotic differences between two adjacent lumbar disc pairs (range −0.5° to 9.0°, p = 0.009), while MLG was more harmonious (range 2.2°–6.5°, p > 0.4). MLG patients were more likely to undergo realignment to age-adjusted standards (OR 5.6, 95% CI 1.2–46.4; p = 0.033). MLG patients were less likely to develop neurological complications or undergo reoperation (OR 0.4, 95% CI 0.1–0.9; p = 0.041). Adjusted analysis revealed that MLG patients more often met a substantial clinical benefit in the Oswestry Disability Index score (OR 5.3, 95% CI 1.1–26.8; p = 0.043).

CONCLUSIONS
MLG techniques showed better utility in lumbar distribution and age-adjusted global correction while minimizing neurological complications and reoperation rates by 2 years postoperatively. In selected instances, these techniques may offer the spine deformity surgeon a safer alternative when correcting severe adult spinal deformity.
Dissecting Alzheimer’s Disease Risk in Asian American Elders: A Classification and Regression Tree Approach
Authors: Moon Sung Seek , Anderson Lindsey , Liu Jinyu , Lee Jinwon , Moon Youngkwang 
Published: March 2024

Background: Alzheimer’s disease (AD) poses a growing public health challenge, particularly with an aging population. While extensive research has explored the relationships between AD, socio-demographic factors, and cardiovascular risk factors, a notable gap exists in understanding these connections within the Asian American elderly population. Objective: This study aims to address this gap by employing the Classification and Regression Tree (CART) approach to investigate the intricate interplay of socio-demographic variables, cardiovascular risk factors, sleep patterns, prior antidepressant use, and AD among Asian American elders. Methods: Data from the 2017 Uniform Data Set, provided by the National Alzheimer’s Coordinating Center, were analyzed, focusing on a sample of Asian American elders ( n = 4,343). The analysis utilized the Classification and Regression Tree (CART) approach. Results: CART analysis identified critical factors, including levels of independence, specific age thresholds (73.5 and 84.5 years), apnea, antidepressant use, and body mass index, as significantly associated with AD risk. Conclusions: These findings have far-reaching implications for future research, particularly in examining the roles of gender, cultural nuances, socio-demographic factors, and cardiovascular risk elements in AD within the Asian American elderly population. Such insights can inform tailored interventions, improved healthcare access, and culturally sensitive policies to address the complex challenges posed by AD in this community.
The burden of low back pain in adolescents and young adults
Authors: Wu Zhiming , Huang Guoxin , Ai Jinwei , Liu Ying , Pei Bin 
Published: March 2024

BACKGROUND: Low back pain is highly prevalent and the main cause of years lived with disability, but data on the burden and trends of low back pain (LBP) in adolescents and young adults (AYAs) are sparse. OBJECTIVE: To assess trends in the burden of LBP among AYAs aged 15–39 years at the global, regional and national levels from 1990 to 2019. METHODS: Data from the Global Burden of Disease (GBD) 2019 were used to analyze incidence, prevalence and Disability-adjusted life year (DALY) due to LBP at global, regional, and national levels. Joinpoint regression analysis calculated the average annual percentage changes (AAPC). Then analyse the association between incidence, prevalence and DALYs and socioeconomic development using the GBD Socio-demographic Index (SDI). Finally, projections were made until 2030 and calculated in Nordpred. RESULTS: The incidence, prevalence and DALYs rates (95%UI) were 2252.78 (1809.47–2784.79), 5473.43 (4488.62–6528.15) and 627.66 (419.71–866.97) in 2019, respectively. From 1990 to 2019, the incidence, prevalence, and DALYs rates AAPC (95%CI) were -0.49 (-0.56 to -0.42), -0.58 (-0.65 to -0.51) and -0.57 (-0.64 to -0.5), respectively. Incidence, prevalence, and DALYs rates in South Asia, East Asia, High-income North America, Western Europe, and Australasia decreased with SDI. Incidence, prevalence, and DALYs rates in Central Asia, Central Europe, and Eastern Europe decreased and then increased with SDI. At the national level, the incidence, prevalence, and DALYs rates are high in the United States and low in India and China. From the 2020 to 2030, most regions is predicted to decline. CONCLUSION: LBP in AYAs is a major global public problem with a high burden. There are large differences in incidence, prevalence and DALYs across SDIs, regions and countries. there is still a need to focus on LBP in AYAs and tailor interventions to reduce the future burden of this condition.
The immediate effect of thoracolumbar fascia taping on biomechanical properties, low back pain and balance in individuals with transfemoral amputation
Authors: Çalışkan Zehra , Alaca Nuray , Kablan Nilüfer 
Published: March 2024

BACKGROUND: In individuals with transfemoral amputation (TFA), adaptations caused by prosthesis use may adversely affect contractile/noncontractile structures. OBJECTIVE: To investigate the immediate effect of the thoracolumbar fascia (TLF) kinesiology taping (KT) on the tone and stiffness of the fascia, low back pain (LBP) and standing balance in individuals with TFA. METHODS: Syrian male participants with TFA were enrolled in the prospective, single-blind, randomised controlled trial. Participants were divided into two groups: Experimental (EG with KT, n= 15) and Control (CG with sham KT, n= 14). A 6-minute walk test (6MWT) was performed, after which KT was applied. Measurements were taken at baseline, immediately after the 6MWT and 30 minutes after KT. RESULTS: Although pain decreased below baseline in both groups at 30 minutes post intervention (p< 0.001), the rate of pain reduction was significantly higher in the EG (p= 0.016). Anterior-posterior sway with eyes open improved significantly 30 minutes after KT application only in the EG (p= 0.010). In the eyes closed condition, anterior-posterior and medio-lateral sway decreased significantly compared to baseline 30 minutes after taping in the EG (p= 0.010-0.032). CONCLUSION: KT can be used as an effective method to support standing balance and reduce LBP in individuals with TFA.
Caloric Restriction Improves Spatial Learning Deficits in Tau Mice
Authors: Cogut Valeria , McNeely Taylor L. , Bussian Tyler J. , Graves Sara I. , Baker Darren J. 
Published: March 2024

Background: Caloric restriction (CR) has been recognized for its benefits in delaying age-related diseases and extending lifespan. While its effects on amyloid pathology in Alzheimer’s disease (AD) mouse models are well-documented, its effects on tauopathy, another hallmark of AD, are less explored. Objective: To assess the impact of a short-term 30% CR regimen on age-dependent spatial learning deficits and pathological features in a tauopathy mouse model. Methods: We subjected male PS19 tau P301S (hereafter PS19) and age-matched wildtype mice from two age cohorts (4.5 and 7.5 months old) to a 6-week 30% CR regimen. Spatial learning performance was assessed using the Barnes Maze test. Tau pathology, neuroinflammation, hippocampal cell proliferation, and neurogenesis were evaluated in the older cohort by immunohistochemical staining and RT-qPCR. Results: CR mitigated age-dependent spatial learning deficits in PS19 mice but exhibited limited effects on tau pathology and the associated neuroinflammation. Additionally, we found a decrease in hippocampal cell proliferation, predominantly of Iba1+ cells. Conclusions: Our findings reinforce the cognitive benefits conferred by CR despite its limited modulation of disease pathology. Given the pivotal role of microglia in tau-driven pathology, the observed reduction in Iba1+ cells under CR suggests potential therapeutic implications, particularly if CR would be introduced early in disease progression.
Dementia Knowledge, Attitude toward Dementia, and Confidence in Dementia Care: Impact of a Dementia Training on German Nursing Students
Authors: Seltmann Henriette , Teichmann Birgit 
Published: March 2024

Background: The number of people with dementia (PwD) in acute care hospitals is steadily increasing, posing a challenge for those who work closely with patients. To date, no German study has addressed the extent to which prospective nurses benefit from dementia training in terms of their knowledge, attitudes, and confidence in caring for PwD. Objective: The aim of this study is to investigate whether a validated dementia training for registered nurses can positively change nursing students’ knowledge about dementia, their attitude toward PwD, and their confidence in caring for them, as well as the stability over time. Methods: In the one-group pre-test, post-test design, a sample of 81 nursing students was recruited from two nursing schools in Germany between May and June 2023. They completed a questionnaire consisting of the Dementia Knowledge Assessment Scale, the Dementia Attitude Scale, and the Confidence in Dementia Scale, as well as sociodemographic questions and experiences with PwD at three measurement points. The data were analyzed using the Wilcoxon test and repeated measures ANOVA. Results: The training has a significant effect on knowledge in dementia ( z = –5.07, p < 0.001), attitude toward PwD ( z = –4.42, p < 0.001), and confidence in caring for them at the post-test ( z = –3. 21, p < 0.001, r = 0.36). The repeated measures ANOVA shows stability over time only for dementia knowledge. Conclusions: The results indicate the need for further research in this field as well as the validation of the dementia training specifically addressing nursing students.
Authors: Suzana Yenny , Hanum Lathifah , Kartika Sonia , Zain Ulfa 
Published: March 2024

Berdasarkan analisis kebutuhan di MIS Terpadu Kota Langsa ditemukan kurangnya kepekaan siswa terhadap lingkungan, minimnya kemampuan literasi numerasi siswa, guru cenderung menggunakan bahan ajar yang telah ada yang diperoleh dari penerbit sehingga tidak sesuai dengan karakteristik serta budaya siswa. Tujuan dari makalah ini adalah untuk melakukan pendampingan literasi numerasi berbasis go green pada guru dan siswa dengan menanamkan nilai-nilai profetik. Pelaksanaan pendampingan dilakukan di dalam dan di luar ruang kelas dalam menumbuhkan kemampuan literasi numerasi berbasis gogreen. Tehnik pendampingan menggunakan pendekatan Asset Based Community Development (ABCD). Langkah-langkah pendekatan ABCD diawali analisis kebutuhan dengan melihat aset-aset yang dimiliki Madrasah, merumuskan permasalahan, dan merancang/mengembangkan bahan pembelajaran bersama guru-guru kelas 2 yang terlibat, dan mendampingi guru melaksanakan kegiatan pembelajaran materi penjumlahan bilangan bulat berbasis gogreen di dalam dan di luar kelas dengan menanamkan nilai profetik, melakukan evaluasi dan umpan balik terhadap kemajuan siswa, serta melaksanakan Focus Group Discution (FGD). Kegiatan pengabdian ini melibatkan kepala madrasah, wakil kepala madrasah bidang kurikulum, guru kelas 2, dan seluruh siswa kelas II MIS Terpadu kota Langsa. Teknik pengumpulan data dengan cara observasi partisipatif yaitu abdimas turut serta terlibat langsung dalam subjek yang diteliti. Adanya keterlibatan langsung pada aktifitas keseharian subjek yang diamati untuk memperoleh pandangan dan pemaknaan subjek terhadap kegiatan-kegiatan yang berlangsung. Angket respon guru dan siswa terhadap kegiatan yang dilaksanakan, dan dokumentasi. Data yang diperoleh berupa data emic dan data etic kemudian dianalisis kata, prasa, selanjutnya diorganisasi. Data yang telah terorganisasi tersebut dirangkum kemudian digeneralisasi dan dibuat kesimpulan.
Inhibition Effect of N-Hexane Extract of Cherry Mistletoe Leaves (Dendropthtoe pentandra (L) Miq.) on Xanthine Oxidase
Authors: Saputra Mario , Sinulingga Sadakata , Subandrate Subandrate 
Published: March 2024

Introduction. Cherry leaf extract has been found to have the potentiality to impede the xanthine oxidase enzyme. It is believed that cherry mistletoe leaves also possess similar properties as they are hemiparasites of their host. This study aims to determine the inhibition effect of N-Hexane extract of mistletoe cherry leaves on the xanthine oxidase. Methods. This research was conducted as an experimental in-vitro study. Cherry mistletoe leaves were extracted by N-Hexane solvent. The extract was divided into five doses, i.e. 40 mg/L, 20 mg/L, 10 mg/L, 5 mg/L, and 2.5 mg/L. Phytochemical screening was conducted to identify secondary metabolites. The impact of xanthine oxidase inhibition was quantified using a UV-vis spectrophotometer at wavelength of 400 nm. Results. N-Hexane extract of cherry mistletoe leaves contains alkaloids and triterpenoids. N-Hexane extract of mistletoe cherry leaves at a dose of 40 mg/L, 20 mg/L, 10 mg/L, 5 mg/L, and 2.5 mg/L was able to inhibit the xanthine oxidase enzyme with the line equation y = -0.2543x+ 91.305. The IC50 value for the N-Hexane extract of cherry mistletoe leaves is 162 mg/L Conclusion. N-Hexane extract of cherry mistletoe leaves has the potency to inhibit the xanthine oxidase enzyme in the medium category.
Propuesta de modelo matemático para calcular el rendimiento de mando de obra en mampostería de bloque. Caso: ciudad de Cuenca, parroquia Cañaribamba
Authors: Coronel García Micaela Geovanna , Calle Castro Carlos Julio , Ávila Calle Marco 
Published: March 2024

Introducción. La colocación de la mampostería de bloque emerge como una fase crítica en el proceso constructivo, donde la eficiencia y precisión influyen directamente en la duración y calidad del proyecto. Esta actividad, aunque aparentemente simple, conlleva una complejidad inherente que a menudo resulta en retrasos significativos en la ejecución de la obra. La necesidad de comprender y abordar los factores que contribuyen a estos retrasos es evidente, ya que su impacto no solo se refleja en términos de cronograma y presupuesto, sino también en la satisfacción del cliente. Objetivo. Proponer un modelo matemático para calcular el rendimiento de la mano de obra en la colocación de mampostería con bloques en la Parroquia Cañaribamba, Cuenca, Ecuador. Metodología. El diseño metodológico adoptado sigue una orientación relacional y descriptiva, involucrando la recopilación de datos de nueve obras mediante una ficha de observación que abarca tanto factores externos como internos. Utilizando estos datos, se llevó a cabo un análisis de regresión lineal mediante un programa estadístico. Resultados. Los resultados destacan que, individualmente, ningún factor analizado influye significativamente en el rendimiento laboral; sin embargo, la combinación de estos factores permite prever el rendimiento con una precisión del 93.3%. Conclusión. Se concluye que la regresión lineal emerge como una herramienta robusta para anticipar el rendimiento de cuadrillas de obreros en la Parroquia Cañaribamba, considerando la complejidad de factores tanto internos como externos en las obras. Área de estudio general: Ingeniería, Industria y Construcción Área de estudio específica: Administración de la Construcción
IMPLEMENTASI GREEN CHEMISTRY PADA PRAKTIKUM KIMIA DI SMAN 2 REJANG LEBONG
Authors: Sura Menda Ginting  , Wiwit  , Elvinawati  , Darwanto Wijaya  , Elisabet Vianey  
Published: March 2024

Community service of Chemistry Education Study Program was conducted in SMAN (senior high school) 2 Rejang Lebong, Bengkulu. This activity aimed to introduce green chemistry-based practicum module in electronic form, with the topic of reaction rate factors and titration reaction using natural indicator. The activities were product introduction, demonstration of using the e-module, discussion, and evaluation toward students’ response of the e-module. The activity was attended by 20 students and three chemistry teachers from SMAN 2. This e-module encouraged schools to conduct chemistry practicum using surrounding ingredients based on green chemistry concept. Students’ response towards e-module showed good response proven by scores gained toward appearance, content, green chemistry aspects, and usability were 80,19%, 82,68%, 94,22%, and 86,63% respectively.
Keywords: green chemistry, practicum, community service
The effect of an extended culture period on birth weight among singletons born after single or double vitrified embryo transfer
Authors: Wang Ningling , Lin Kaibo , Zhao Xinxi , Zhang Ping 
Published: March 2024

AimTo evaluate the effect of an extended culture period on birth weight among singletons born after vitrified-warmed embryo transferMethodsA retrospective cohort study was performed among 12400 women who gave birth to 1015, 1027, 687, and 9671 singletons after single blastocyst transfer, single cleavage-stage embryo transfer, double blastocyst transfer, and double cleavage-stage embryo transfer, respectively.ResultsThe unadjusted birth weight of singletons born after vitrified blastocyst transfer were heavier than those born after cleavage-stage transfer (β=30.28, SE=13.17, P=0.022), as were the adjusted birth weights (β=0.09, SE=0.03, P=0.007). In addition, there was a 37% increased odd of having an infant with high birth weight after vitrified blastocyst transfer compared with vitrified cleavage stage transfer (OR=1.37, 95% CI:1.07-1.77).ConclusionThe unadjusted and adjusted birth weight and odds of having an infant with high birth weight significantly increased after blastocyst transfer compared with cleavage-stage embryo transfer in vitrified-warmed cycles.