bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vertical variation in swelling properties of Norway spruce bark depending on tree age and bark moisture content
Authors: Ilek Anna , Płachta Agnieszka , Siegert Courtney , Campos Sergio Dias , Szostek Małgorzata , Tonello Kelly Cristina 
Published: April 2024

AbstractIn forest ecosystems, interception of rainwater on foliar and woody surfaces and the subsequent partitioning into stemflow is largely controlled by physical and hydrological properties of bark. Few forest ecohydrology studies have explored the role of bark properties (e.g., thickness, density) on bark water storage capacity and stemflow production. Even fewer have explored how different phases of water (e.g., liquid, vapor) may affect bark through bark swelling properties across the stem and how the degree of swelling affects tradeoffs between bark water storage and stemflow generation. Thus, the objective of this study was to analyze changes in a bark swelling index (BSI) vertically along stems of Picea abies (Norway spruce) after exposure to both water vapor and liquid water, as a function of tree age and bark moisture content. We found that tree age influenced BSI and bark moisture content, wherein BSI was ∼ 6.5% lower in older trees (70 years) compared to younger trees (35 and 50 years), and average moisture content was 10.4–13.2% lower. BSI increased when bark was exposed to hygroscopic water vapor and reached maximum swelling after 1 day of water saturation. BSI also increased from the base of the tree to 20–30% of total tree height, beyond which BSI remained relatively stable across all age classes. Enhanced understanding of bark swelling mechanisms as a result of stem position, age, and moisture content and exposure provide stronger foundations for understanding canopy hydrologic partitioning and the fate of rainwater moving through forest canopies.
Correlation between extraocular muscle enlargement and thyroid autoantibodies in thyroid eye disease
Authors: Koizumi Takahiro , Tanaka Takahiro , Umeda Kazuki , Komiyama Daisuke , Obata Hiroto 
Published: April 2024

Abstract
Purpose
This study aimed to investigate the factors affecting extraocular muscle enlargement in thyroid eye disease (TED).

Study design
Retrospective study.

Methods
The thyroid-stimulating hormone (TSH) receptor antibody (TRAb), thyroid-stimulating antibody (TSAb), antithyroid peroxidase antibody (ATPO), and antithyroglobulin antibody (ATG) levels in patients diagnosed with TED who underwent orbital magnetic resonance imaging were assessed. The control group comprised the contralateral eye of patients who underwent orbital magnetic resonance imaging (MRI) for unilateral eyelid tumors or orbital disease. The thickness of the bilateral rectus muscles and superior oblique muscles was measured on orbital MRI. Muscle enlargement was classified as unilateral/bilateral and symmetric/asymmetric. The effects of age, sex, smoking history, TSH, thyroid hormone, and thyroid autoantibodies on the muscle thickness and number of enlarged muscles were assessed by use of simple and multiple regression analyses.

Results
The TED and control groups comprised 41 and 44 cases, respectively. The positivity rate of TSAb in patients with TED was 92.7% higher than that of the other autoantibodies. Muscle enlargement was observed in 29 of the 41 cases (70.7%). Older age and higher TSAb levels were identified as significant factors affecting the total muscle thickness and number of enlarged muscles. Bilateral muscle enlargement and asymmetrical muscle enlargement were observed in 17 (58.6%) and 23 (79.3%) of the 29 cases, respectively. The TSAb levels and age had no significant effect on the type of muscle enlargement.

Conclusions
TSAb showed significant associations with extraocular muscle enlargement. Measurement of TSAb, rather than of TRAb, may be more useful for diagnosing extraocular muscle enlargement in patients with TED.
Synthesis of Na-Alginate templated Montmorillonite-Silica Composite as adsorbent for removal of Rhodamine B
Authors: Deveci İlyas 
Published: April 2024

AbstractIn this study, mesoporous Montmorillonite-Silica composites prepared by using different amount Alginate as sacrificial template, for removal of Rhodamine B is investigated. By alternating Alginate amount it is aimed to switch the porosity of adsorbents thus the adsorption capacities of adsorbents. Synthesized adsorbents had been characterized by using Scanning Electron Microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and N2-Ads/Des techniques. It is observed that beside the decrease in the micropore volume, the total pore volume of the adsorbents increased with the increasing of used Alginate amount. The total pore volumes of adsorbents synthesized with different Clay/Alginate ratio (10, 5, 1) were found as 0.116, 0.172, and 0.178 cm3/g, respectively. Batch adsorption studies showed that the maximum removal efficiencies were obtained at acidic conditions and the adsorbents had better fit with Freundlich isotherm. Qm values obtained from Langmuir isotherm were found as 24.47, 31.97 and 28.48 mg/g for synthesized adsorbents. Also, adsorption kinetic studies showed that for all adsorbents, experimental data had good fit to the pseudo-second order kinetics model. The model parameters were found as 5.9,6.3 and 6.5 (10–3 g/ (mg min). Thermodynamic parameters were also investigated in the study. Negative ∆Go values pointed out that the adsorption of RhB onto synthesized adsorbents was favorable process. Positive values of ∆Ho and ΔS indicated that the adsorption of RhB on adsorbents were endothermic and rising of randomness during the adsorption of RhB on the surface of the adsorbent. Adsorbents could be recovered at least five times without significant decrease in adsorption capacity.
Early Effects of Scaling Up Dolutegravir-Based ARV Regimens Among Children Living with HIV in Malawi
Authors: Makonokaya Lucky , Maida Alice , Kalitera Louiser Upile , Wang Alice , Kapanda Lester , Kayira Dumbani , Bottoman Madalitso , Nkhoma Harrid , Dunga Shalom , Joaki Zuze , Chamanga Rachel , Nkanaunena Kondwani , Hrapcak Susan , Nyirenda Rose , Chiwandira Brown , Maulidi Martin , Woelk Godfrey , Machekano Rhoderick , Maphosa Thulani 
Published: April 2024

AbstractViral suppression (VS) in children has remained suboptimal compared to that in adults. We evaluated the impact of transitioning children weighing < 20 kg to a pediatric formulation of dolutegravir (pDTG) on VS in Malawi. We analyzed routine retrospective program data from electronic medical record systems pooled across 169 healthcare facilities in Malawi supported by the Elizabeth Glaser Pediatric AIDS Foundation (EGPAF). We included children who weighed < 20 kg and received antiretroviral therapy (ART) between July 2021–June 2022. Using descriptive statistics, we summarized demographic and clinical characteristics, ART regimens, ART adherence, and VS. We used logistic regression to identify factors associated with post-transition VS. A total of 2468 Children Living with HIV (CLHIV) were included, 55.3% of whom were < 60 months old. Most (83.8%) had initiated on non-DTG-based ART; 71.0% of these had a viral load (VL) test result before transitioning to pDTG, and 62.5% had VS. Nearly all (99.9%) CLHIV transitioned to pDTG-based regimens. Six months after the transition, 52.7% had good ART adherence, and 38.6% had routine VL testing results; 81.7% achieved VS. Post-transition VS was associated with good adherence and pre-transition VS: adjusted odds ratios of 2.79 (95% CI 1.65–4.71), p < 0.001 and 5.32 (95% CI 3.23–9.48), p < 0.001, respectively. After transitioning to pDTG, VS was achieved in most children tested within the first 6 months. However, adherence remained suboptimal post-transition and VL testing at 6 months was limited. Interventions to improve VL testing and enhance ART adherence are still needed in CLHIV on pDTG-based regimens.
Lob-based deep learning models for stock price trend prediction: a benchmark study
Authors: Prata Matteo , Masi Giuseppe , Berti Leonardo , Arrigoni Viviana , Coletta Andrea , Cannistraci Irene , Vyetrenko Svitlana , Velardi Paola , Bartolini Novella 
Published: April 2024

AbstractThe recent advancements in Deep Learning (DL) research have notably influenced the finance sector. We examine the robustness and generalizability of fifteen state-of-the-art DL models focusing on Stock Price Trend Prediction (SPTP) based on Limit Order Book (LOB) data. To carry out this study, we developed LOBCAST, an open-source framework that incorporates data preprocessing, DL model training, evaluation, and profit analysis. Our extensive experiments reveal that all models exhibit a significant performance drop when exposed to new data, thereby raising questions about their real-world market applicability. Our work serves as a benchmark, illuminating the potential and the limitations of current approaches and providing insight for innovative solutions.
A new semi-local centrality for identifying influential nodes based on local average shortest path with extended neighborhood
Authors: Xiao Yi , Chen Yuan , Zhang Hongyan , Zhu Xinghui , Yang Yimin , Zhu Xiaoping 
Published: April 2024

AbstractQuantifying the importance of nodes in complex networks is known as the problem of identifying influential nodes and is considered a critical aspect in interacting with these networks. This problem has many applications such as controlling rumors, sickness spreading, and viral marketing, where its importance has been understood by the research society in the last decade. This paper proposes a new semi-local centrality to identify influential nodes in complex networks based on the theory of Local Average Shortest Path with extended Neighborhood concept (LASPN). LASPN focuses on a distributed technique to extract the subgraph associated with each node and apply the average shortest path theory to it. We use the extended neighborhood concept to find the nearest neighbors of each node with low complexity, where this can lead to high efficiency in dealing with large-scale networks. In addition to applying relative changes in the average shortest path, the proposed metric considers the importance of the node itself as well as its nearest neighbors in ranking the nodes. Evaluation of the proposed centrality metric has been done through numerical simulations on several real-world networks. The results based on Kendall's $$\tau$$
τ
coefficient under the SIR infection spreading model show that LASPN improves the performance by 2.7% compared to the best available equivalent method.
Targeting PNPO to suppress tumor growth via inhibiting autophagic flux and to reverse paclitaxel resistance in ovarian cancer
Authors: Li Xin , Guan Wencai , Liu Huiqiang , Yuan Jia , Wang Fanchen , Guan Bin , Chen Junyu , Lu Qi , Zhang Lingyun , Xu Guoxiong 
Published: April 2024

AbstractOur previous study showed that pyridoxine 5’-phosphate oxidase (PNPO) is a tissue biomarker of ovarian cancer (OC) and has a prognostic implication but detailed mechanisms remain unclear. The current study focused on PNPO-regulated lysosome/autophagy-mediated cellular processes and the potential role of PNPO in chemoresistance. We found that PNPO was overexpressed in OC cells and was a prognostic factor in OC patients. PNPO significantly promoted cell proliferation via the regulation of cyclin B1 and phosphorylated CDK1 and shortened the G2M phase in a cell cycle. Overexpressed PNPO enhanced the biogenesis and perinuclear distribution of lysosomes, promoting the degradation of autophagosomes and boosting the autophagic flux. Further, an autolysosome marker LAMP2 was upregulated in OC cells. Silencing LAMP2 suppressed cell growth and induced cell apoptosis. LAMP2-siRNA blocked PNPO action in OC cells, indicating that the function of PNPO on cellular processes was mediated by LAMP2. These data suggest the existence of the PNPO-LAMP2 axis. Moreover, silencing PNPO suppressed xenographic tumor formation. Chloroquine counteracted the promotion effect of PNPO on autophagic flux and inhibited OC cell survival, facilitating the inhibitory effect of PNPO-shRNA on tumor growth in vivo. Finally, PNPO was overexpressed in paclitaxel-resistant OC cells. PNPO-siRNA enhanced paclitaxel sensitivity in vitro and in vivo. In conclusion, PNPO has a regulatory effect on lysosomal biogenesis that in turn promotes autophagic flux, leading to OC cell proliferation, and tumor formation, and is a paclitaxel-resistant factor. These data imply a potential application by targeting PNPO to suppress tumor growth and reverse PTX resistance in OC.
MARCH5 promotes aerobic glycolysis to facilitate ovarian cancer progression via ubiquitinating MPC1
Authors: Xu Ying , Zhao Shuhua , Shen Yujie , Li Yuanfeng , Dang Yinghui , Guo Fenfen , Chen Zhihao , Li Jia , Yang Hong 
Published: April 2024

AbstractMARCH5 is a ring-finger E3 ubiquitin ligase located in the outer membrane of mitochondria. A previous study has reported that MARCH5 was up-regulated and contributed to the migration and invasion of OC cells by serving as a competing endogenous RNA. However, as a mitochondrial localized E3 ubiquitin ligase, the function of MARCH5 in mitochondrial-associated metabolism reprogramming in human cancers remains largely unexplored, including OC. We first assessed the glycolysis effect of MARCH5 in OC both in vitro and in vivo. Then we analyzed the effect of MARCH5 knockdown or overexpression on respiratory activity by evaluating oxygen consumption rate, activities of OXPHOS complexes and production of ATP in OC cells with MARCH5. Co-immunoprecipitation, western-blot, and in vitro and vivo experiments were performed to investigate the molecular mechanisms underlying MARCH5-enhanced aerobic glycolysis s in OC. In this study, we demonstrate that the abnormal upregulation of MARCH5 is accompanied by significantly increased aerobic glycolysis in OC. Mechanistically, MARCH5 promotes aerobic glycolysis via ubiquitinating and degrading mitochondrial pyruvate carrier 1 (MPC1), which mediates the transport of cytosolic pyruvate into mitochondria by localizing on mitochondria outer membrane. In line with this, MPC1 expression is significantly decreased and its downregulation is closely correlated with unfavorable survival. Furthermore, in vitro and in vivo assays revealed that MARCH5 upregulation-enhanced aerobic glycolysis played a critical role in the proliferation and metastasis of OC cells. Taken together, we identify a MARCH5-regulated aerobic glycolysis mechanism by degradation of MPC1, and provide a rationale for therapeutic targeting of aerobic glycolysis via MARCH5-MPC1 axis inhibition.
Data breaches in healthcare: security mechanisms for attack mitigation
Authors: Nemec Zlatolas Lili , Welzer Tatjana , Lhotska Lenka 
Published: April 2024

AbstractThe digitalisation of healthcare has increased the risk of cyberattacks in this sector, targeting sensitive personal information. In this paper, we conduct a systematic review of existing solutions for data breach mitigation in healthcare, analysing 99 research papers. There is a growing trend in research emphasising the security of electronic health records, data storage, access control, and personal health records. The analysis identified the adoption of advanced technologies, including Blockchain and Artificial Intelligence, alongside encryption in developing resilient solutions. These technologies lay the foundations for addressing the prevailing cybersecurity threats, with a particular focus on hacking or malicious attacks, followed by unauthorised access. The research highlights the development of strategies to mitigate data breaches and stresses the importance of technological progress in strengthening data security. The paper outlines future directions, highlighting the need for continuous technological progress and identifying the gaps in the attack mitigations.
Making Order in Household Accounting - Digital Invoices as Domestic Work Artifacts
Authors: Dethier Erik , Kern Dean-Robin , Stevens Gunnar , Boden Alexander 
Published: April 2024

Abstract
The digitization of financial activities in consumers' lives is increasing, and the digitalization of invoicing processes is expected to play a significant role, although this area is not well understood regarding the private sector. Human-Computer Interaction (HCI) and Computer Supported Cooperative Work (CSCW) research have a long history of analyzing the socio-material and temporal aspects of work practices that are relevant for the domestic domain. The socio-material structuring of invoicing work and the working styles of consumers must be considered when designing effective consumer support systems. In this ethnomethodologically-informed, design-oriented interview study, we followed 17 consumers in their daily practices of dealing with invoices to make the invisible administrative work involved in this process visible. We identified and described the meaningful artifacts that were used in a spatial-temporal process within various storage locations such as input, reminding, intermediate (for postponing cases) buffers, and archive systems. Furthermore, we identified three different working styles that consumers exhibited: direct completion, at the next opportunity, and postpone as far as possible. This study contributes to our understanding of household economics and domestic workplace studies in the tradition of CSCW and has implications for the design of electronic invoicing systems.
Can Text-Based Statistical Models Reveal Impending Banking Crises?
Authors: du Plessis Emile 
Published: April 2024

AbstractThis paper introduces statistical models Wordscores and Wordfish to study and predict banking crises. While Wordscores is akin to supervised learning, Wordfish is analogous to unsupervised learning. Both methods estimate the position of banking distress on a tranquil-to-crisis spectrum. Findings suggest that the two statistical methods signal banking crisis up to two-years in advance, with robust results from AUROC, Granger causality and VAR impulse responses. Both methods outperform random forests in predicting crises using textual data. The Wordscores index highlights increased usage of banking sector nomenclature two years preceding a crisis, and Granger causes a crisis series with one and two lag lengths. Results from the Wordfish technique, a statistical model with Poisson distribution, show the index spikes before and during the Global Financial Crisis, when a large share of the countries in the world encountered banking crises. This paper contributes to literature on text-based models of banking crises by bolstering the preemptive policy responses available to policy makers. Given their early warning signals, both Wordscores and Wordfish can be considered a part of the toolset to monitor the stability and resilience of the banking sector.
How do we learn in and from Hackathons? A systematic literature review
Authors: Schulten Cleo , Chounta Irene-Angelica 
Published: April 2024

AbstractThis paper presents an analysis of the current research landscape around hackathons and hackathon-like events as opportunities and means for learning. In particular, we aimed to explore how hackathon-like events are utilized to promote learning, what systematic approaches are used to orchestrate learning in such events, and to what extent knowledge is systematized and standardized in this context. To that end, we conducted a Systematic Literature Review following established guidelines. In this review we studied 39 research papers published over a 10-year span. Our findings indicate that no standardized setup for hackathons to promote learning and to assess learning outcomes has been investigated exhaustively. We did not find a systematic approach to reliably produce or measure learning effects in hackathons. Most of the reviewed papers relied on perceived learning for the assessment of learning. Based on the consulted literature, this does not provide comprehensive proof of positive learning outcomes from hackathons. We, therefore, conclude that additional research is needed to gather insights and consequently work toward solidifying the role of hackathons as learning tools. This work contributes to exploring the landscape and proposing research directions for capitalizing on the potential of hackathons and similar events for learning.
Assessing water diversion impacts on the fish community size structure in headwater stream stretches
Authors: Gurí Rosa , Benejam Lluís , Ordeix Marc , Arranz Ignasi 
Published: April 2024

AbstractWater diversion for hydropower plants is one of the leading causes of habitat alteration and biotic homogenization. The impacts of small hydropower plants on fish communities are usually assessed using taxonomic composition and structure indicators. Size-based indicators are useful tools to evaluate the effects of environmental factors and anthropogenic perturbations on riverine ecosystems. In this study, we investigated the impact of water diversion on fish community body size structure in 16 small hydropower plants in the upper Ter River basin (NE Iberian Peninsula). We tested the use of multiple size-based metrics under different sampling intensities (one- vs. four-pass electrofishing) and compared control vs. diverted stream stretches. Results revealed that water diversion had a negative effect on fish community average and median length, while size spectrum and size diversity metrics showed no responses to the impact. Altitude was positively related with body size metrics and was the strongest natural driver affecting them. Moreover, we found that all the size-based metrics exhibited consistent values under different sampling efforts. Our findings suggest that size-based metrics could be useful indicators for bioassessment of river flow alteration and that one-pass electrofishing was robust enough to characterize the stream fish community size structure in our study.
Dynamic adaptation of phytoplankton vertical migration to changing grazing and nutrient conditions
Authors: Salonen Kalevi , Järvinen Marko , Aalto Taavi , Likolammi Markit , Lindblom Visa , Münster Uwe , Sarvala Jouko 
Published: April 2024

AbstractDespite the ubiquitous occurrence of vertical migration of phytoplankton its quantitative significance remains poorly known. We eliminated a dense Daphnia population in a pond by introducing whitefish fingerlings, and assessed the effects on the vertical migration of dominating motile phytoplankton. At the highest abundance of Daphnia, cryptophytes reduced grazing losses by staying in the hypolimnion day and night, but Mallomonas species armoured by silica bristles remained in the epilimnion. After the fish introduction, phytoplankton was released from Daphnia grazing pressure, allowing cryptophytes to occur in the epilimnion also at noon. At the same time, increased phytoplankton biomass exacerbated the nutrient depletion. Cryptophytes compensated for that by migrating into the anoxic hypolimnion, whereupon their growth rates increased. The collapse of Daphnia was also associated with a temporary increase in nutrient regeneration by enzyme activities and decreases in total nutrient concentration and bacterial biomass in the whole water column. Our results show that cryptophytes can dynamically modify their vertical migration to balance between the exploitation of various nutrient resources and the risk of becoming eaten. Hypolimnetic nutrient resources can be quantitatively more important for phytoplankton than previously assumed.