bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenotypic and Immunological Characterization of Patients with Activated PI3Kδ Syndrome 1 Presenting with Autoimmunity
Authors: Li Qifan , Wang Wenjie , Wu Qi , Zhou Qinhua , Ying Wenjing , Hui Xiaoying , Sun Bijun , Hou Jia , Qian Feng , Wang Xiaochuan , Sun Jinqiao 
Published: April 2024

Abstract
Purpose
Autoimmunity is a significant feature of APDS1 patients. We aimed to explore the pathogenic immune phenotype and possible mechanisms of autoimmunity in APDS1 patients.

Methods
The clinical records and laboratory data of 42 APDS1 patients were reviewed. Immunophenotypes were evaluated by multiparametric flow cytometry. Autoantibodies were detected via antigen microarray analysis.

Results
A total of 42 children with PIK3CD gene mutations were enrolled. Immunological tests revealed increased proportions of effector memory cells (86%) and central memory cells (59%) among CD4+ T cells; increased proportions of effector memory cells (83%) and terminally differentiated effector memory T cells (38%) among CD8+ T cells. Fewer CD3+ T cells and B cells and higher IgG levels were reported in patients with autoimmunity. The proportion of Tregs was decreased, and the proportions of Th9, Tfh, and Tfr cells were increased in APDS1 patients. Among APDS1 patients, higher proportion of Th2 and Tfr cells were found in those with autoimmunity. The proportions of CD11c+ B and CD21lo B cells in patients with autoimmunity were significantly increased. Antigen microarray analysis revealed a wide range of IgG/IgM autoantibodies in patients with APDS1. In patients with autoimmunity, the proportion of Tfr might be positively correlated with autoantibodies.

Conclusions
The pathogenic immune phenotype of APDS1 patients included (1) deceased CD3+ T-cell and B-cell counts and increased IgG levels in patients with autoimmunity, (2) an imbalanced T helper cell subset, (3) increased proportions of autoreactive B cells, and (4) distinct autoantibody reactivities in patients with autoimmunity.
Characterisation of different types of power plant ashes as potential lunar regolith simulants
Authors: Mrówka Maciej , Moskal Grzegorz , Tomaszewska Agnieszka , Mikuśkiewicz Marta , Wagner Paweł 
Published: April 2024

AbstractAshes from various Polish coal-fired power plants were analysed in this investigation as the source material for preparing simulants of lunar regolith. The chemical and phase constituents were the most important parameters used to describe these ashes. The second parameter was particle size and morphology, specifically characterising technological properties such as flowability or density. The final element of the investigation was related to the characterisation of thermal properties. Differential thermal analysis yields information on phase transitions, melting temperatures and other characteristic temperatures of stimulants. Thermogravimetry with Fourier transform infrared analysis provides information on evolved gas species and their evolution temperature profiles.
Key breeding habitats of threatened golden eagles across Eastern Canada identified using a multi-level, multi-scale habitat selection approach
Authors: Maynard Laurie D. , Lemaître Jérôme , Therrien Jean-François , Miller Tricia A. , Katzner Todd , Somershoe Scott , Cooper Jeff , Sargent Robert , Lecomte Nicolas 
Published: April 2024

AbstractContextIn a conservation context, identifying key habitats suitable for reproduction, foraging, or survival is a useful tool, yet challenging for species with large geographic distributions and/or living in remote regions.ObjectivesThe objective of this study is to identify selected habitats at multiple levels and scales of the threatened eastern North American population of golden eagles (Aquila chrysaetos). We studied habitat selection at three levels: landscape (second order of selection), foraging (third order of selection), and nesting (fourth order of selection).MethodsUsing tracking data from 30 adults and 366 nest coordinates spanning over a 1.5 million km2area in remote boreal and Arctic regions, we modelled the three levels of habitat selection with resource selection functions using seven environmental features (aerial, topographical, and land cover). We then calculated the relative probability of selection in the study area to identify regions with higher probabilities of selection.ResultsEagles selected more for terrain ruggedness index and relative elevation than land cover (i.e., forest cover, distance to water; mean difference in relative selection strength: 1.2 [0.71; 1.69], 95% CI) at all three levels. We also found that the relative probability of selection at all three levels was ~ 25% higher in the Arctic than in the boreal regions. Eagles breeding in the Arctic travelled shorter foraging distances with greater access to habitat with a high probability of selection than boreal eagles.ConclusionHere we found which aerial and topographical features were important for several of the eagles’ life cycle needs. We also identified important areas to monitor and preserve this threatened population. The next step is to quantify the quality of habitat by linking our multi-level, multi-scale approach to population demography and performance such as reproductive success.
Can GPU performance increase faster than the code error rate?
Authors: dos Santos Fernando Fernandes , Rech Paolo 
Published: April 2024

AbstractGraphics processing units (GPUs) are the reference architecture to accelerate high-performance computing applications and the training/interference of convolutional neural networks. For both these domains, performance and reliability are two of the main constraints. It is believed that the only way to increase reliability is to sacrifice performance, e.g., using redundancies. We show in this paper that this is not always the case. As a very promising result, we found that most GPUs performance improvements also bring the benefit of increasing the number of executions correctly completed before experiencing a silent data corruption (SDC). We consider four different common GPUs’ performance optimizations: architectural solutions, software implementations, compiler optimizations, and threads degree of parallelism. We compare different implementations of a variety of parallel codes and, through beam experiments and applications profiling, we show that the performance improvement typically (but not necessarily) increases the GPU SDC rate. Nevertheless, for the vast majority of the configurations the performance gain is much higher than the SDC rate increase, allowing to process a higher amount of correct data. As we show, the programmer choices can increase up to $$25\times {}$$

25
×

the number of correctly completed executions without redesigning the algorithm nor including specific hardening solutions.
Can episodic memory deter cheating and promote altruism?
Authors: Keven Nazim 
Published: April 2024

AbstractEpisodic memory gives us the ability to mentally travel back in time to revisit and relive past experiences. In recent years, there has been an increased interest in the function of episodic memory. According to the orthodox view, episodic memory should be considered a part of a constructive system that simulates the future for sophisticated foresight and flexible planning. In this paper, I offer a novel alternative view. I argue that episodic memory provides invaluable information about the past behavior of others, allowing us to identify reliable and trustworthy partners while avoiding dealing with cheaters. Theoretical models demonstrate that cooperation in groups can be maintained if potential partners use information about an individual’s past behavior to guide their behavior toward that individual. In these reputation-based models of human cooperation, individuals with a history of cheating are ostracized, whereas those with a history of cooperative behavior flourish. Against this theoretical background, it is possible to see a function of episodic memory in facilitating information exchange about others, helping group members make effective partner choices, and avoiding the risk of interacting with cheaters. If correct, episodic memory may have played a significant role in the evolution of human cooperation.
Restricted nominalism about number and its problems
Authors: Snyder Eric , Samuels Richard , Shapiro Stewart 
Published: April 2024

AbstractHofweber (Ontology and the ambitions of metaphysics, Oxford University Press, 2016) argues for a thesis he calls “internalism” with respect to natural number discourse: no expressions purporting to refer to natural numbers in fact refer, and no apparent quantification over natural numbers actually involves quantification over natural numbers as objects. He argues that while internalism leaves open the question of whether other kinds of abstracta exist, it precludes the existence of natural numbers, thus establishing what he calls “restricted nominalism” about natural numbers. We argue that Hofweber’s internalism fails to establish restricted nominalism. Not only is his primary argument for restricted nominalism invalid, the analysis of quantification proposed threatens to collapse internalism into either a traditional form of error theory or realism.
A comprehensive examination of temporal-seasonal variations of PM1.0 and PM2.5 in taiwan before and during the COVID-19 lockdown
Authors: Room Shahzada Amani , Chiu Yi Chen , Pan Shih Yu , Chen Yu-Cheng , Hsiao Ta-Chih , Chou Charles C.-K. , Hussain Majid , Chi Kai Hsien 
Published: April 2024

AbstractCOVID-19 has been a significant global concern due to its contagious nature. In May 2021, Taiwan experienced a severe outbreak, leading the government to enforce strict Pandemic Alert Level 3 restrictions in order to curtail its spread. Although previous studies in Taiwan have examined the effects of these measures on air quality, further research is required to compare different time periods and assess the health implications of reducing particulate matter during the Level 3 lockdown. Herein, we analyzed the mass concentrations, chemical compositions, seasonal variations, sources, and potential health risks of PM1.0 and PM2.5 in Central Taiwan before and during the Level 3 lockdown. As a result, coal-fired boilers (47%) and traffic emissions (53%) were identified as the predominant sources of polycyclic aromatic hydrocarbons (PAHs) in PM1.0, while in PM2.5, the dominant sources of PAHs were coal-fired boilers (28%), traffic emissions (50%), and iron and steel sinter plants (22.1%). Before the pandemic, a greater value of 20.9 ± 6.92 μg/m3 was observed for PM2.5, which decreased to 15.3 ± 2.51 μg/m3 during the pandemic due to a reduction in industrial and anthropogenic emissions. Additionally, prior to the pandemic, PM1.0 had a contribution rate of 79% to PM2.5, which changed to 89% during the pandemic. Similarly, BaPeq values in PM2.5 exhibited a comparable trend, with PM1.0 contributing 86% and 65% respectively. In both periods, the OC/EC ratios for PM1.0 and PM2.5 were above 2, due to secondary organic compounds. The incremental lifetime cancer risk (ILCR) of PAHs in PM2.5 decreased by 4.03 × 10-5 during the pandemic, with PM1.0 contributing 73% due to reduced anthropogenic activities.
Financial health and economic growth responsiveness as solution to environmental degradation in Pakistan
Authors: Golo Mansoor Ahmed , Han Dongping , Balsalobre-Lorente Daniel , Radulescu Magdalena 
Published: April 2024

AbstractThis study analyses the impact of GDP per capita, domestic credit, savings, and population on the environment in Pakistan from 1995 to 2019. The country has consistently been ranked eighth, fifth, and eight as an environmentally vulnerable nation from 1998 to 2017, 1999 to 2018, and 2000 to 2019, respectively. Therefore, the study explores the role of environmental awareness as a potential strategy for making peace with nature. Findings of the ARDL bounds testing approach confirm the long-run cointegration among variables of concern. In further assessment, the study determines that increased per capita income is detrimental to environmental quality in the long run. However, in the short run, it shows a favourable impact. On the other hand, domestic credit worsens the environment in the long and short runs. However, savings are positively insignificant in this regard. Furthermore, the total population significantly harms the environment in the long and short run. Fortunately, environmental awareness has emerged as a key solution to environmental degradation in Pakistan. Findings show that an increase in the dissemination of environmental awareness through the Internet, mobile, and landline phones, as well as by increasing education expenditures, mitigates the populations’ detrimental impact on the environment and improves environmental quality in the long run.
Graphical Abstract
Cash Transfers and After-School Programs: A Randomized Controlled Trial for Young Men at Risk of Violence Exposure in Wilmington, Delaware
Authors: Stacy Christina Plerhoples , Teles Daniel , González-Hermoso Jorge , Walker Fay , Morgan Anna , Huettner Steven , Thornton Rachel L. J. , Matson Pamela A. 
Published: April 2024

AbstractWe conducted a randomized controlled trial to determine whether an after-school program paired with a cash transfer (a conditional cash transfer) or a cash transfer alone (an unconditional cash transfer) can help improve health and economic outcomes for young men between the ages of 14 and 17 whose parents have low incomes and who live in neighborhoods with high crime rates. We find that receiving the cash transfer alone was associated with an increase in healthy behaviors (one of our primary outcome composite measures) and that the cash transfer paired with after-school programming was associated with an improvement in the financial health of participants (one of our secondary outcome composite measures). We find no differences in spending on alcohol, marijuana, cigarettes, or other drugs between either the treatment group and the control group. Neither the cash transfer alone nor the programming plus cash transfer had statistically significant effects on our other primary composite measures (physical and mental health or school attendance and disciplinary actions), or our other secondary composite measures (criminal justice engagement or social supports) but in most cases, confidence intervals were too large to rule out meaningful effects. Results suggest that cash transfers hold promise to improve the health of youth without any indication of any adverse effects.
Limiting money: redesigning the artifact that shapes modern people
Authors: Hornborg Alf 
Published: April 2024

AbstractThe transdisciplinary argument in this article is that the social and ecological unsustainability of modern, globalized capitalism ultimately derives from the design of its central artifact: what Polanyi called all- or general-purpose money. The notion of a singular measure of economic value is a peculiar cultural conception that is inherently at odds with physical reality, yet it pervades modern economic thought and practice as if it were immutable. To transcend the political impasse of economic globalization, a complementary national currency (CC) exclusively for local use could distinguish a sphere of exchange and special-purpose currency for basic needs from a global sphere of more remote exchange-values. To avoid the pitfalls and failures of earlier experiments with local currencies, such a CC would require the support of national authorities, the specified objective of sustainable consumption and production, and systematic efforts to provide citizens and entrepreneurs with ample incentives to utilize it. In combining the concept of a CC with that of a universal basic income (UBI), the reform would allow their advantages to complement each other, joining the generalized scale of UBI with the potential of politically influencing consumption patterns that is inherent in CC. An essential difference in relation to earlier experiments would be that the reach of the CC would not be defined in terms of the geographical location of retailers but in terms of the derivation, relative to the consumer, of the products and services into which it could be converted. Although no such system yet exists, this should not stop us from imagining its possibilities.
Comparison of Old and New Systemic Treatments for Moderate to Severe Atopic Dermatitis
Authors: Yim Hyun J. , Jean Tiffany , Ong Peck Y. 
Published: April 2024

Abstract
Purpose of Review
Historically, systemic treatments for atopic dermatitis (AD) primarily consisted of immunosuppressive agents such as corticosteroids and Disease Modifying Antirheumatic Drugs (DMARDS), which provided symptomatic relief but often had long-term adverse effects. Newer treatments have shown significant efficacy with less side effects in clinical trials. This review discusses and compares conventional and newer systemic treatments for AD.

Recent Findings
Newer medications for AD including dupilumab, tralokinumab, lebrikizumab, and oral JAK inhibitors have been shown to be safe and efficacious. High dose cyclosporine and dupilumab were more effective than methotrexate and azathioprine in improving clinical signs of AD. High-dose upadacitinib was shown in another meta-analysis to be most effective in the measured outcomes but had the highest frequency of adverse events.

Summary
Targeted biologic treatments are increasingly favored over traditional immunosuppressive treatments of AD. Treatment can be individualized based on potency, adverse side effects, mechanism of action, and administration preference. Ongoing research continues to expand treatment options for AD.
Perceived parental psychological control and the risk of internet gaming disorder in adolescents: a cross-sectional study
Authors: Turan Nazan , Alkan Afra , Çekiç Yasemin 
Published: April 2024

AbstractIt is stated that parental psychological control (PC), which appears to hinder psychological development in children and adolescents, is associated with internet gaming disorder (IGD). However, parenting styles and practices vary across cultures. For this reason, to determine the risk of IGD in adolescents who are in the process of psychological development and to prevent it at an early stage, there is a need to better understand the effect of PC on the development of IGD. In this context, this study aims to examine the impact of perceived parental psychological control on the risk of Internet gaming disorder in Turkish adolescents. A cross-sectional design was used. The sample group consisted of 4498 students from eight public high schools in Turkey. Participant Information Form, the Psychological Control Scale, and the Internet Gaming Disorder Scale Short Form were used for collecting data. Univariate logistic regression analysis demonstrated that the risk of IGD increased as maternal disrespect-maternal psychological control and father disrespect scores increased. Paternal psychological control score had no significant effect on IGD risk. In the multivariate model, age, father’s education level, spending money on games, time spent playing daily games on weekdays and weekends, and father’s psychological score were found to be associated with IGD risk. The effects of maternal disrespect and maternal psychological control scores on the IGD risk varied according to the number of siblings and the education level of the mother. As a result, parental PC was determined to affect the risk of IGD in Turkish adolescents significantly.
The impact of acculturation and psychological wellbeing on South Asian immigrant adolescents and youth: a scoping review
Authors: Kodippili Tirani , Ziaian Tahereh , Puvimanasinghe Teresa , Esterman Adrian , Clark Yvonne 
Published: April 2024

AbstractAmong the global immigrant population, one of the fastest growing populations is the South Asian community. South Asian youth have experienced difficulties acculturating to the host culture. These difficulties have caused issues relating to identity and conflicts with family members relating to dating, marriage, and education. This scoping review will aim to summarize the literature available on acculturation and psychological well-being. The scoping review followed the Preferred Reporting Items for Systematic Review and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR) and Askey & O’Malley’s approach to data extraction. During the initial search, 220 full-text articles were retrieved from the APA PsycInfo, Web of Science, Medline, and Scopus databases. Ten articles were included in the final review. The following four themes were formulated: acculturation style, family conflict, coping style, and discrimination. We highlight that policies supporting collaboration between mental health practitioners, educators, researchers, and South Asian communities are critical for creating intervention programs that help South Asian families.
The Influence of Time, Tide, and Place on Fine-Scale Nekton Distribution: Insights from the San Francisco Estuary
Authors: Young Matthew J. , Feyrer Frederick , Hassrick Jason , Acuña Shawn , Ayers David , Donovan John , Grimaldo Lenny 
Published: April 2024

AbstractThe location of estuarine organisms varies based on geophysical cycles and environmental conditions, which can strongly bias understanding of organism abundance and distribution. In the San Francisco Estuary, California, extensive monitoring surveys have provided insight into the life history and ecology of certain commercially important or legislatively protected fish species. However, there remains substantial uncertainty in factors influencing the vertical and lateral distributions of many other nekton species in the San Francisco Estuary, including longfin smelt Spirinchus thaleichthys, for whom such distributional information may highly influence interpretation of existing data. We carried out paired sampling using surface and demersal gears to address three questions: (1) Does diel phase influence the vertical position of nekton (e.g., surface versus demersal)? (2) Do environmental conditions, specifically turbidity, influence the vertical and lateral positions of nekton (e.g., center channel versus peripheral shoal)? (3) Does tidal variability influence vertical and lateral distributions of nekton? We documented variability in sampled nekton densities across diel phase (day/night), vertical position (surface/bottom), and lateral position (channel/shoal). Tidal phase and turbidity concentration influenced vertical and lateral distributions for some species at certain locations. Although infrequently encountered, we documented associations of longfin smelt with the lower water column and shoal habitats, with some evidence for upward vertical shifts in low light conditions brought about by nightfall or elevated turbidity. Observed habitat associations provide insight into how interacting geophysical and environmental factors may influence the distribution of nekton and thus the vulnerability of individual species to detection by sampling gears.
The future of clinical trials—goals, ideas, and discussion
Authors: Gnant Michael , Gili Manuela , Schwarz Magdalena , Fesl Christian , Hlauschek Dominik , Jallitsch-Halper Anita , Fohler Hannes 
Published: April 2024

SummaryClinical trials are subject to an ever-evolving landscape of treatment options, regulatory requirements, socioeconomic conditions, and paradigms of scientific research. In this opinion paper, we illustrate current methods and topics with a focus on clinical trial designs, conduct and modes of collaboration. The example of successful clinical breast cancer research in Austria demonstrates the opportunities, but also the challenges for academic research. We also investigate potential pitfalls, and suggest new ideas and strategies on how to increase practicability along with transparency and fairness, but ultimately also scientific and clinical relevance of clinical trials in oncology.