bluuebunny/crossref_metadata_2025_split huggingface dataset:
Commercial Transaminases for the Asymmetric Synthesis of Bulky Amines
Authors: Haarr Marianne B. , Sriwong Kotchakorn T. , O'Reilly Elaine 
Published: March 2024

AbstractTransaminase‐catalysed asymmetric amination is a valuable transformation for the synthesis of chiral amines. However, its use in synthetic chemistry has been curtailed by a narrow substrate scope and limited information on commercially available catalysts. In this work we have explored the substrate scope of selected commercially available transaminases, focusing on prochiral ketones bearing two bulky substituents and their application in both enzyme‐catalysed and enzyme‐triggered reactions. (R)‐ and/or (S)‐selective enzymes converted methyl‐, isopropyl‐, n‐butyl‐, and cyclohexyl‐phenone substrates to the corresponding amines in the range of 6–>99 % ee. In some cases, a stereochemical switch was detected, in which (R)‐enantioselectivity was observed with enzymes typically assigned as (S)‐selective. Upscaling of selected biotransformations provided chiral amines, in >99 % ee and up to 40 % isolated yield. Furthermore, transaminase‐triggered reactions, which were previously limited to methyl‐ and ethyl‐derivatives, were expanded to phenyl‐derivatives for the formation of a cis‐2,6‐disubstituted piperidine and 2,4‐diphenyl pyrroline, and isolated in up to 67 % yield.
Emerging nitric oxide gas‐assisted cancer photothermal treatment
Authors: Liang Shuang , Liu Yufei , Zhu Hongquan , Liao Guangfu , Zhu Wenzhen , Zhang Li 
Published: March 2024

AbstractPhotothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one of the most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed to enable the simultaneous utilization of PTT and NO‐mediated gas therapy (GT), with the integration of photothermal agents (PTAs) and thermally‐sensitive NO donors being the prevailing approach. This combination seeks to leverage the synergistic effects of PTT and GT while mitigating the potential risks associated with gas toxicity through the use of a single laser irradiation. Furthermore, additional internal or external stimuli have been employed to trigger NO release when combined with different types of PTAs, thereby further enhancing therapeutic efficacy. This comprehensive review aims to summarize recent advancements in NO gas‐assisted cancer photothermal treatment. It commences by providing an overview of various types of NO donors and precursors, including those sensitive to photothermal, light, ultrasound, reactive oxygen species, and glutathione. These NO donors and precursors are discussed in the context of dual‐modal PTT/GT. Subsequently, the incorporation of other treatment modalities such as chemotherapy (CHT), photodynamic therapy (PDT), alkyl radical therapy, radiation therapy, and immunotherapy (IT) in the creation of triple‐modal therapeutic nanoplatforms is presented. The review further explores tetra‐modal therapies, such as PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic therapy (CDT), PTT/GT/PDT/IT, PTT/GT/starvation therapy (ST)/IT, PTT/GT/Ca2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, and PTT/GT/CDT/IT. Finally, potential challenges and future perspectives concerning these novel paradigms are discussed. This comprehensive review is anticipated to serve as a valuable resource for future studies focused on the development of innovative photothermal/NO‐based cancer nanotheranostics.
Premature luteinization and pregnancy outcomes in depot goserelin‐downregulated assisted reproductive technology cycles: A cross‐sectional study from Ethiopia
Authors: Mekuria Thomas , Wondafrash Mekitie , Sium Abraham Fessehaye 
Published: March 2024

AbstractObjectiveTo compare the rate of premature luteinization in depot goserelin‐downregulated in vitro fertilization (IVF) cycles with other IVF protocols at a teaching hospital in Ethiopia.MethodsWe conducted a cross‐sectional study on the effects of premature luteinization on IVF outcomes at St. Paul's Hospital Millennium Medical College, a tertiary teaching hospital in Ethiopia. Patients who had IVF at this hospital between 2019 and 2020 were included in the study. Patient records were reviewed and collected on Open Data Kit. We used Stata release 15 to analyze the data. A simple descriptive analysis and bivariate analysis were performed as appropriate. A P‐value less than 0.05 was considered as statistically significant.ResultsA total of 305 patients (40 cases with premature luteinization and 265 without premature luteinization) were included. There was no difference in the rate of premature luteinization in the depot goserelin long protocol cycles (6.4%), compared to minimal stimulation (14.1%) and antagonist protocols (16.7%), P = 0.19. Embryo transfer was carried out in 27 (67.5%) patients in the premature luteinization group, which was lower than the 86.0% (228/265) in the non‐premature luteinization group, P = 0.003. There was no difference in the median number of oocytes retrieved (8.5 [interquartile range 5.0, 13.0] per cycle in the premature luteinization group vs 5.0 [interquartile range 3.0, 10.0] in those without premature luteinization, P = 0.10).ConclusionA depot goserelin‐downregulated long protocol for IVF is a cost‐effective and convenient option for controlled ovarian hyperstimulation without increased risk of having premature luteinization compared to antagonist and minimal stimulation protocols.
Investigating proton tunneling dynamics in the time‐dependent Schrödinger equation
Authors: Nanni Luca 
Published: March 2024

AbstractUnderstanding the temporal evolution of the wave function in the proton tunneling reactions allows us to make theoretical predictions on the possible femtosecond spectroscopy patterns. However, the analytical solution of the time‐dependent Schrödinger equation of complex molecules is challenging and requires a high computational cost. In this study, we solve the time‐dependent Schrödinger equation using the Fourier grid Hamiltonian method, highlighting its simplicity of calculation, even for multidimensional tunneling reactions. The obtained model is applied to studying malonaldehyde's two‐dimensional intramolecular proton tunneling, comparing the results with those obtained using other computational methods.
MyD88 exacerbates inflammation‐induced bone loss by modulating dynamic equilibrium between Th17/Treg cells and subgingival microbiota dysbiosis
Authors: Hsiao Po‐Yan , Huang Ren‐Yeong , Huang Lin‐Wei , Chu Ching‐Liang , Dyke Thomas Van , Mau Lian‐Ping , Cheng Chia‐Dan , Sung Cheng‐En , Weng Pei‐Wei , Wu Yu‐Chiao , Shieh Yi‐Shing , Cheng Wan‐Chien 
Published: March 2024

AbstractBackgroundThis study aimed to investigate the contribution of myeloid differentiation primary‐response gene 88 (MyD88) on the differentiation of T helper type 17 (Th17) and regulatory T (Treg) cells and the emerging subgingival microbiota dysbiosis in Porphyromonas gingivalis‐induced experimental periodontitis.MethodsAlveolar bone loss, infiltrated inflammatory cells, immunostained cells for tartrate‐resistant acid phosphatase (TRAP), the receptor activator of nuclear factor‐kB ligand (RANKL), and osteoprotegerin (OPG) were quantified by microcomputerized tomography and histological staining between age‐ and sex‐matched homozygous littermates (wild‐type [WT, Myd88+/+] and Myd88−/− on C57BL/6 background). The frequencies of Th17 and Treg cells in cervical lymph nodes (CLNs) and spleen were determined by flow cytometry. Cytokine expression in gingival tissues, CLNs, and spleens were studied by quantitative polymerase chain reaction (qPCR). Analysis of the composition of the subgingival microbiome and functional annotation of prokaryotic taxa (FAPROTAX) analysis were performed.ResultsP. gingivalis‐infected Myd88−/− mice showed alleviated bone loss, TRAP+ osteoclasts, and RANKL/OPG ratio compared to WT mice. A significantly higher percentage of Foxp3+CD4+ T cells in infected Myd88−/− CLNs and a higher frequency of RORγt+CD4+ T cells in infected WT mice was noted. Increased IL‐10 and IL‐17a expressions in gingival tissue at D14–D28 then declined in WT mice, whereas an opposite pattern was observed in Myd88−/− mice. The Myd88−/− mice exhibited characteristic increases in gram‐positive species and species having probiotic properties, while gram‐negative, anaerobic species were noted in WT mice. FAPROTAX analysis revealed increased aerobic chemoheterotrophy in Myd88−/− mice, whereas anaerobic chemoheterotrophy was noted in WT mice after P. gingivalis infection.ConclusionsMyD88 plays an important role in inflammation‐induced bone loss by modulating the dynamic equilibrium between Th17/Treg cells and dysbiosis in P. gingivalis‐induced experimental periodontitis.
Automatic welding-robot programming based on product-process-resource models
Authors: Sarivan Ioan-Matei , Madsen Ole , Wæhrens Brian Vejrum 
Published: March 2024

AbstractThis paper describes a novel end-to-end approach for automatic welding-robot programming based on a product-process-resource (PPR) model, for one-of-a-kind manufacturing systems. Traditionally, the information needed to program a welding robot is processed and transferred along the manufacturing organisation’s value chain by using several stand-alone digital systems which require extensive human input and high skill to operate. A PPR model is proposed through this research as a platform for storing and processing the necessary information along the value chain seamlessly. Unlike existing approaches which make use of complex algorithms to automatically identify the weldment seams, the approach suggested in this research makes use of information already digitalised by design engineers under the form of ISO 2553:2019 compliant weldment annotations. Hence, the PPR model contains the weldment annotations; it enables the automatic programming of welding robots and reduces human input down to a few minutes only. The applicability in manufacturing of the theoretical concept is demonstrated through technical implementations tested in the laboratory and on the value chain of an engineering-to-order (ETO) industrial partner involved in the metal fabrication industry. The experiments were conducted by creating several products using the proposed artefact. Experiments show that automatic programming of welding robots can be achieved using PPR models. The conducted experiments showed a reduction of about 80% in human input measured in terms of time, when using the proposed solution. The reduction of the human input can free up skilled labour resource which ETO SMEs can reallocate to other tasks.
The illusory certainty: Information repetition and impressions of truth enhance subjective confidence in validity judgments independently of the factual truth
Authors: Stump Annika , Voss Andreas , Rummel Jan 
Published: March 2024

AbstractPeople not only judge repeatedly perceived information as more likely being true (the so-called truth effect) they also tend to be more confident after judging the validity of repeated information. These phenomena are assumed to be caused by a higher subjective feeling of ease (i.e., fluency) when processing repeated (vs. new) information. Based on the suggestion that a higher number of coherent mental activations is promoting a fluency experience, we argue that besides repetition an already existing information network, that is (nonspecific) prior knowledge, can enhance fluency. Following this argumentation, information repetition as well as the act of judging incoming information as being true (vs. false) should feed into subjective confidence – independently of the factual truth (when judging under uncertainty). To test this, we reanalyzed two published data sets and conducted a new study. In total, participants (N = 247) gave 29,490 truth judgments and corresponding ratings of subjective confidence while attending two judgement phases (i.e., 10 min and 1 week after the exposure phase in each experiment). Results showed that (a) repetition (in 3 of 3 data sets) and (b) impressions of truth (in 2 of 3 data sets) were systematically related to higher subjective confidence. Moreover, we found (c) a significant positive interaction between repetition and impressions of truth after both intervals in all data sets. Our analyses further underline the moderating effect of time: Influences of repetition significantly decreased with increasing time interval. Notably, the factual truth did not systematically affect any of the above reported effects.
Real-life management of patients with mild cognitive impairment: an Italian survey
Authors: Bonanni Laura , Cagnin Annachiara , Carrarini Claudia , Logroscino Giancarlo , Marra Camillo , Rainero Innocenzo 
Published: March 2024

Abstract
Background
Mild cognitive impairment (MCI) is a syndrome with heterogeneous underlying causes and different rates of disease progression, whose clinical heterogeneity leads to a wide variation in diagnostic and therapeutic approaches in clinical practice. The lack of uniform practical recommendations on diagnostic workup and treatment for MCI patients hinders optimal management of these patients, worsening their prognosis. Standardized guidelines for the investigation and follow-up of MCI are therefore urgently required.

Aim
Aim of our study was to assess the diagnostic and therapeutic approach to MCI patients in the setting of Italian Memory Clinics.

Methods
A survey was delivered to a sample of Italian neurologists through two different phases: a first exploratory phase recording general information about the usual clinical management of patients with MCI, and a subsequent operative phase assessing the practical diagnostic and therapeutic decisions taken in a real life setting to manage subjects with MCI.

Results
A total of 121 neurologists participated to the first phase of the survey and 203 patients were enrolled in the second phase. Information gathered in the first phase of the survey highlighted a non-uniform use of diagnostic criteria and procedures for MCI, as well as a very heterogeneous therapeutic strategy among Italian neurologists. In the second phase, recorded data on diagnostic and therapeutic approach confirmed the large variability observed in the first phase of the survey.

Conclusions
The results of our study reflect a suboptimal management of MCI patients in Italy and highlight the need of standardized diagnostic and therapeutic approaches for this condition.
The morphosyntax of Gothic preverb compounds: incorporation and applicativisation
Authors: Tan Tamisha L. 
Published: March 2024

AbstractGothic preverb compounds illustrate several interesting characteristics, including multiple preverb stacking, idiomatisation, tmesis (i.e., separation by clitics), and P-copying (i.e., multiple pronunciation of the preverb). This paper is a close examination of the morphosyntax of these compounds, highlighting novel empirical generalisations about the Gothic language with key theoretical implications for our understanding of Germanic complex verbs and the alternations they participate in. In particular, this paper proposes a structural distinction between preverb compounds which are obligatorily semantically transparent and those which are optionally idiomatic. In arguing that transparent compounds involve the mechanism of preposition incorporation and m-merger, paralleling recent accounts of clitic doubling, while idiomatic compounds involve a thematic high applicative projection, this paper captures nuanced differences in these compounds’ case assignment and argument licensing behaviour. These structural differences will be shown to derive these two compound types’ constrained interaction with the aforementioned phenomena of stacking, tmesis, and copying. In addition, this paper compares Gothic complex verbs to their cross-linguistic correlates within and beyond Germanic, whilst also providing a diachronic pathway for the development of (multiple) preverb compounds.
A Robust Aluminum Material Selection Process in the Aviation Industry: A Linear Discrete System Stability Test Perspective for Fuzzy Multicriteria Decision-Making
Authors: Ic Yusuf Tansel , Hamzaoğlu Burak Meriç , Yurdakul Mustafa 
Published: March 2024

AbstractAluminum parts are used in the aviation industry because of the need for light. However, in addition to lightness, critical parts that must have high strength properties have also been developed. The corrosion resistance, resistance to high temperatures, and workability were investigated in this case. It becomes difficult to choose among many aluminum materials that can be alternatives to each other when these features are included. The developed approach, which considers many of the features listed above and ultimately recommends to the user the most suitable aluminum material for the relevant critical part, will be used in overcoming the difficulties in this process. A material selection model is proposed in this paper for this purpose, and the decision-making model is demonstrated with examples from the aviation industry. Therefore, the developed model, which will enable the selection of the most suitable materials among alternative materials, especially for critical parts in the aviation industry, will guide professionals working in this field. For this purpose, the fuzzy TOPSIS method is used in the study, and suitable alternatives are determined. Finally, a robustness analysis is proposed to determine the most suitable aluminum material for highly uncertain situations. We apply a stability evaluation study based on process control theory in the robustness analysis.
Spectral transformations and second kind polynomials associated with a hermitian linear functional
Authors: García-Ardila Juan Carlos , Marcellán Francisco 
Published: March 2024

AbstractThe aim of this paper is to analyze the relation between the Christoffel transformations in the framework of hermitian linear functionals and the associated polynomials of the second kind through of their associated Carathéodory formal power series. In particular, some results are given in the way of characterization of linear spectral transformations using Christoffel and Geronimus transformations. This gives a new example of rational spectral transformation that has not yet been studied in the literature.
Failure pressure prediction of high-strength steel pipe bend considering pipe and corrosion geometry
Authors: Vijaya Kumar Suria Devi , Karuppanan Saravanan , Perumal Veeradasan , Ovinis Mark 
Published: March 2024

AbstractThis study examines the influence of pipe bend geometry and corrosion geometry on the failure pressure of high-strength steel pipe bends subjected to internal pressure and axial compressive stress. Finite element analysis determines the impact of bend angle, bending radius, defect depth, defect length, defect spacing, and axial compressive stress on failure pressures. The findings reveal that increasing the bend angle reduces failure pressures significantly, with corrosion defects exacerbating this effect. Increased bending radius increases normalized failure pressure from 0.88 to 0.91 for intrados defects and decreases it from 0.98 to 0.93 for extrados defects. Additionally, single defects cause a slight 2.5–3.0% reduction in normalized failure pressure, while longitudinally and circumferentially aligned defects result in a 13–15% decrease in normalized failure pressure. Defect depth and length also significantly influence the failure pressure, particularly for deeper and longer defects (up to 48.2%). Furthermore, an empirical equation for predicting failure pressures in corroded pipe bends with high accuracy (R2 = 0.99) is developed based on Artificial Neural Network. This enhances pipeline integrity assessment and design practices.
Adapting a youth suicide prevention program for rural communities in the United States: a feasibility study
Authors: Weissman Ruth Striegel , Scott Brandon G. , Edwards Kelley , Rose Jennifer S. , Kuntz Matthew , Wilcox Holly C. 
Published: March 2024

AbstractRural youth suicide represents a major source of mental health inequity in the United States (US). School-based suicide prevention programs may provide an effective avenue to address this mental health crisis among rural youth. This study’s primary goal is to demonstrate the feasibility and acceptability of a novel implementation approach (utilizing teachers from a neighboring school) for delivering the Youth Aware of Mental Health (YAM) program, an evidence-based, universal youth suicide prevention curriculum, to high school students in rural Montana. We will recruit approximately 1300 9th grade student in four Montana schools. Using a non-inferiority design, we will randomize classrooms in each school to be instructed by a teacher from another school (YAM-TE; experimental) or a traditional external instructor (YAM-EXT; control). We will assess program fidelity of both YAM training and implementation via independent observer and instructor-reporter ratings. Youth will complete measures of acceptability at post-YAM and outcome measures at pre-YAM, post-YAM, and 12 month follow-up. Standard and mixed linear and logistic regression models will be used to test the main hypothesis that the YAM-TE does not differ from YAM-EXT regarding fidelity (teachers) and acceptability (teachers and youth). Exploratory analyses will test moderation of the intervention effect (e.g., sex, poverty) and the mediating effect of mental health literacy, belongingness, and perceived burdensomeness on the intervention effect. Results of this pilot study will inform the development of subsequent, fully powered noninferiority trials. Our long-term goal is to scale YAM-TE for implementation across rural US communities or, if culturally appropriate, more globally.
International human rights standards versus cultural practices: a case against harmful cultural practices in Sub-Saharan Africa, with a specific reference to FGM
Authors: Dau Santino Ayuel Longar 
Published: March 2024

AbstractOne of the major limitations of the cultural relativist contention is its property to rank group rights above and beyond individual rights. This paper, however, contends that such a postulation is utilitarian in character. It suggests that what is good for the many is conclusive as to the justness of an outcome. The paper further underscores that IHRs regime must be seen as an indivisible structure of interconnected sets of rights and freedoms within which the significance of each right and/or freedom is augmented or guaranteed by the synchronous protection of all other rights and/or freedoms. This proposition is pertinent to the enduring tension between IHRs standards and cultural practices in the African debate on human rights. Indeed, when juxtaposed against IHRs standards, certain cultural practices are evidently inimical to the inherent human dignity, contrary to the universal vision for the human rights regime. It stands to reason that, in the event of an irreconcilable friction between individual and group rights, the former must supersede the latter. The paper concludes that the long-standing normativity of specific traditional or cultural practices cannot plausibly be invoked as a defense for the continuation of harmful cultural practices, such as FGM, considering that such practices hardly ever fall within the meaning of the group right to culture under IHRL and are, therefore, pernicious to the IHRs standards as culturally constituted.