bluuebunny/crossref_metadata_2025_split huggingface dataset:
First‐Line Levofloxacin‐Based Triple Therapy Versus Standard Bismuth‐Based Quadruple Therapy for Helicobacter pylori Eradication in Saudi Arabia: A Retrospective Single‐Center Study
Authors: Abdulqader Abdulrhman Khaled Al , Alamri Turki Abdullah , Alhamad Mahdi Abdullah , Shehab El‐Deen Somaia , Essa Abdallah , Alfayez Raed Abdullah , Albaqshi Baqer Mohammed , Almajed Adnan Salah , Alhassan Mohammed Yousef , Essa Ali , Albadrani Ahmed Abdullah , Alomair Omar , Al Jalal Bashaeer Abdullh , Almulhim Mohammed Yousef , Alotaibi Abdullah , Darwish Ehab 
Published: February 2025

ABSTRACTBackground and AimsAntibiotic resistance in Saudi Arabia has led to decreased efficacy of conventional triple therapy for Helicobacter pylori (H. pylori) eradication, prompting the development of alternative treatments like levofloxacin‐based triple and bismuth‐based quadruple therapies. However, comparative data regarding its efficacy are lacking. Therefore, this study's goal was to compare the efficacy of levofloxacin‐based triple therapy with that of standard bismuth‐based quadruple therapy as first‐line regimens.MethodsThis retrospective analysis included 197 treatment‐naïve adults with H. pylori infection who received levofloxacin‐based triple (levofloxacin + amoxicillin + PPI) therapy (n = 81) or standard bismuth‐based quadruple (bismuth + tetracycline + metronidazole + PPI) therapy (n = 116). H. pylori eradication was evaluated 4–8 weeks after medication administration using the 13C‐urea breath test, and variables that could affect the rate of success were examined.ResultsThere were no differences between groups in terms of age, sex, nationality, or type of proton pump inhibitor (PPI) used. The bismuth‐based quadruple therapy group exhibited a markedly superior success rate compared to the levofloxacin‐based triple therapy group when the latter was administered for 7 or 10 days (81.03% vs. 6.66%, p < 0.001, and 81.03% vs. 36.1%, p < 0.001, respectively). However, when the levofloxacin‐based triple therapy was extended to 14 days, its H. pylori eradication rate became comparable to that of the 10‐day bismuth‐based quadruple therapy (81.03% vs. 80%, p = 0.898). Eradication rates for both regimens were similar for patients aged ≥ 60, non‐Saudi, when using omeprazole and those treated with levofloxacin‐based triple therapy for 14 days.ConclusionQuadruple treatment based on bismuth is superior to triple therapy based on levofloxacin for eradicating H. pylori in Saudi Arabia and should be used as a first‐line treatment. However, the 14‐day levofloxacin‐based triple treatment had an H. pylori eradication rate comparable to that of the 10‐day bismuth‐based quadruple therapy.
Climate Change and Investors' Behaviour: Assessing a New Type of Systematic Risk
Authors: Thampanya Natthinee , Wu Junjie 
Published: February 2025

ABSTRACTThis study explores how temperature anomalies, a novel form of systematic risk, affect financial markets, expanding the traditional understanding of market‐wide risks. While climate change is becoming an important consideration, the extent to which temperature anomalies disrupt economic activities and influence stock returns is urgently needed to assess. Using data from 479 Thai companies (2010–2023), we apply linear and nonlinear autoregressive distributed lag (ARDL) models to examine the impact of temperature anomalies and investor sentiment on stock returns. Our findings reveal that (1) temperature anomalies significantly affect short‐term stock returns, especially when prioritising sustainability and environmental, social, and governance (ESG) factors; (2) public awareness, measured by Google Search Volume Index (GSVI), has a complex, nonlinear impact on the stock market; (3) temperature anomalies act like traditional risk measures, influencing stock returns similarly to market volatility. The study highlights the growing importance of climate change in financial decision‐making and offers insights into investor reactions to climate risks and economic sentiment. It emphasises the need to consider short‐term market reactions to climate‐related news and suggests that temperature anomalies could be viewed as a systematic risk in financial markets.
Albert Bandura: The Man I Have Known and His Merits
Authors: Caprara Gian Vittorio 
Published: February 2025

ABSTRACTAlbert Bandura, one of the most influential psychologists, passed away on 26 July 2021. His scientific merits have been acknowledged across various domains of inquiry, thereby attesting to his relevance for understanding people's agentic role in shaping and improving their life. The purpose of this special issue was to honour Bandura's contribution to psychological science through a collection of articles from several researchers around the globe whose scientific interests are rooted in Bandura's theoretical conceptualisations, ranging from self‐efficacy beliefs to moral disengagement.
The Effect of Impulsivity Traits on Commission Errors of Prospective Memory
Authors: Guo Yunfei , Tu Jiaru , Wang Mingyuan , Gan Jiaqun , Li Yimin 
Published: February 2025

ABSTRACTRepeated execution of a prospective memory (PM) task that has already been completed is known as a commission error of the PM. Due to defects in attentional impulsiveness and motor impulsiveness, impulsive individuals may differ from non‐impulsive individuals when making PM commission errors. This study explored the effect of impulsivity traits on PM commission errors under different ongoing task difficulties (Experiment 1) and different response conveniences (Experiment 2). The results of Experiment 1 showed that the impulsive group had more PM commission errors than the non‐impulsive group under both the low‐difficulty condition and the high‐difficulty condition, indicating that the effect of impulsivity traits on PM commission errors is not affected by the difficulty of ongoing tasks. However, the results of Experiment 2 showed that the impulsive group only had more PM commission errors than the non‐impulsive group under the convenient response condition, indicating that the effect of impulsivity traits on PM commission errors is affected by the response convenience.
Effects of Nitrogen and Hydrogen Plasma Treatments on a Mg‐2Y‐1Zn‐1Mn Resorbable Alloy
Authors: Shekargoftar Masoud , Ravanbakhsh Samira , de Oliveira Vinicius Sales , Paternoster Carlo , Chevallier Pascale , Witte Frank , Sarkissian Andranik , Mantovani Diego 
Published: February 2025

ABSTRACTMg alloys have recently been investigated and optimized for the development of biodegradable implants for orthopedic, dental, vascular, and other applications. However, their rapid degradation in a physiological environment remains the main obstacle to their development. In this work, the effects of nitrogen and hydrogen plasma treatments on the surface properties and corrosion behavior of an Mg‐2Y‐1Zn‐1Mn (WZM211) alloy were investigated. Plasma treatment effectively modified the surface of a WZM211 alloy by removing the original oxide layer, followed by the formation of a new surface layer with controlled composition, thickness, and wettability. The water contact angle decreased from 100° to 17° after nitrogen plasma and to 45° after hydrogen plasma treatment. The nitrogen plasma treatment, shortly N‐Plasma, resulted in the lowest corrosion rate (CRN = 0.038 ± 0.010 mm/y) if compared with the hydrogen plasma treatment, shortly H‐Plasma (CRH = 0.044 ± 0.003 mm/y) and untreated samples (0.233 ± 0.097 mm/y). The results demonstrate the potential of nitrogen and hydrogen plasma treatment for the development of resorbable Mg‐based implants.
Targeting Drug Delivery System to Skeletal Muscles: A Comprehensive Review of Different Approaches
Authors: Li Xiaofang , Xu Jintao , Yao Shanshan , Zhang Ning , Zhang Bao‐Ting , Zhang Zong‐Kang 
Published: February 2025

ABSTRACTThe skeletal muscle is one of the largest organs in the body and is responsible for the mechanical activity required for posture, movement and breathing. The effects of current pharmaceutical therapies for skeletal muscle diseases are far from satisfactory; approximately 24% of Duchenne muscular dystrophy (DMD) trials have been terminated because of unsatisfactory outcomes. The lack of a skeletal muscle‐targeting strategy is a major reason for these unsuccessful trials, contributing to low efficiency and severe side effects. The development of targeting strategies for skeletal muscle‐specific drug delivery has shown the potential for increasing drug concentrations in the skeletal muscle, minimising off‐target effects, and thereby improving the therapeutic effects of drugs. Over the past few decades, novel methods for specifically delivering cargo to skeletal muscles have been developed. In this review, we categorise targeting methods into four types: peptides, antibodies, small molecules and aptamers. Most research has focused on peptide and antibody ligands, and there are several well‐established drugs in this category; however, drawbacks such as protease degradation and immunogenicity limit their use. Aptamers and small molecules have low immunogenicity and are simple to chemically produce. However, small molecule ligands generally exhibit lower affinity because of their small size and high mobility. Aptamers are promising ligands for skeletal muscle‐targeting delivery systems. Additionally, if the active site of the cargo is located inside the cell, an internalisation pathway becomes necessary. The order of internalisation ligands and targeting ligands in the complex is a crucial factor, because an inappropriate order could lead to much lower targeting and internalisation efficiencies. Moreover, ligand density also merits consideration, as increasing the density of the targeting ligands may result in steric hindrance, which could impact the accessibility of the receptor and cause enlargement of the targeted ligands. More efforts are required to optimise drug delivery systems that specifically recognise skeletal muscle, with the aim of enhancing quality of life and promoting patient well‐being.
Multiomics Analysis Reveals Therapeutic Targets for Chronic Kidney Disease With Sarcopenia
Authors: Wang Meiqiu , You Lianghui , He Xu , Peng Yingchao , Wang Ren , Zhang Zhiqiang , Shu Jiaping , Zhang Pei , Sun Xiaoyi , Jia LiLi , Xia Zhengkun , Ji Chenbo , Gao Chunlin 
Published: February 2025

ABSTRACTBackgroundThe presence of sarcopenia in patients with chronic kidney disease (CKD) is associated with poor prognosis. The mechanism underlying CKD‐induced muscle wasting has not yet been fully explored. This study investigates the influence of renal secretions on muscles using multiomics sequencing.MethodsThe kidney transcriptome analysis by RNA‐seq and protein profiling by tandem mass tag (TMT), serum TMT and muscle TMT were performed in CKD established using 0.2% adenine and control mice. Spp1 recombinant protein was used to study its effect on myotube atrophy in vitro. In animal experiments on CKD, pharmacological inhibition of Spp1 was used to explore the role of Spp1 in skeletal muscle wasting. Transcriptome analysis was performed to identify differentially expressed genes (DEGs) in the gastrocnemius muscle following Spp1 pharmacological inhibition.ResultsIn the renal transcriptome and TMT, 503 and 377 proteins/genes respectively were co‐upregulated and co‐downregulated. In the serum TMT of CKD and normal control (NC) mice, 22 upregulated and 7 downregulated differentially expressed proteins (DEPs) showed the same expression patterns as those in the kidney transcriptome and TMT analysis. Based on bioinformatics analysis and reported studies, we selected Spp1 for further validation. Spp1 recombinant protein was added to C2C12 myotubes in vitro, and the results indicated that Spp1 significantly increased the protein levels of the muscle atrophy marker (Murf‐1) and promoted the smaller myotubes (all p < 0.05). Compared with NC mice, Spp1 mRNA and protein levels were significantly upregulated in the kidneys of CKD mice, and the serum concentration of Spp1 was also markedly increased (all p < 0.05). In animal experiments, pharmacological inhibition of Spp1 increased the weights of gastrocnemius and tibialis anterior muscles (p < 0.05) and improved muscle atrophy phenotype. Transcriptome analysis showed that DEGs in the gastrocnemius muscle following Spp1 pharmacological inhibition were enriched in protein digestion and absorption, glucagon signalling pathway, apelin signalling pathway and ECM‐receptor interaction pathway.ConclusionsOur study is the first to establish a regulatory network of kidney‐muscle crosstalk to explore the potential mechanism of CKD‐related sarcopenia. Employing multiomics analysis, cellular assessment and animal experiments, we have identified that Spp1 could potentialy serve as a promising therapeutic target for CKD patients with sarcopenia.
Spanish chickpea gene‐bank seeds (Cicer arietinum L.) offer an enhanced nutritional quality and polyphenol profile compared with commercial cultivars
Authors: Delgado‐Andrade Cristina , Razola‐Díaz Carmen , Olías Raquel , Verardo Vito , Gómez‐Caravaca Ana María , Marcos‐Prado Teresa , Clemente Alfonso 
Published: February 2025

AbstractBACKGROUNDIn the global socioeconomic context and the current climate change scenario, investigating the nutritional and bioactive characteristics of landraces can provide interesting profiles with technological applications and benefits for human health. The purpose of this work was to improve our knowledge regarding the nutritional and phenolic composition of several chickpea accessions preserved in a gene bank compared with widely consumed cultivars, as a first approach to establish their potential nutritional interest. CIELab colour, mineral content, protein, and amino acids were determined, as well as a comprehensive characterization of free and bound phenolic compounds by high‐performance liquid chromatography–electrospray ionization quadrupole time‐of‐flight mass spectrometry.RESULTSThe chickpea accessions displayed a superior macro‐mineral profile and higher levels of protein, arginine, and bound phenolic compounds than commercial cultivars did. The total phenolic content ranged from 307.55 to 940.46 μg g−1 dry weight and clearly categorized the crops into desi or kabuli types. The ratio of free to bound phenolic compounds ranged between 2.8 and 50.2 in the kabuli seeds and 0.4–1.3 in the desi type. The most remarkable finding was the quantification of a total of 42 phenolic compounds, nine of them reported for the first time in chickpea seeds (methyl and dimethyl citric acids, glabranin, 3,4‐dihydroxy‐5‐methoxybenzoic acid, myricetin 3‐O‐rutinoside, dihydromyricetin, phlorizin, kaempferol 7‐(6″‐p‐succinylglucoside) and phloretin).CONCLUSIONSDespite variations in genetic backgrounds and specific agronomic conditions, this research unveils a sufficiently attractive nutritional and phenolic profile to justify further investigations aimed at exploring the future expansion and applications of these chickpea accessions. © 2025 Society of Chemical Industry.
PR‐YOLOv9: An improve defect detection network for hot‐pressed light guide plates
Authors: Liu Cunling , Peng Shuo , Liu Shuangning , Li Junfeng 
Published: February 2025

AbstractAs one of the key components of liquid crystal display, the quality of the hot‐pressed light guide plate (LGP) directly affects the display performance. To address the challenges posed by complex background textures, diverse types of defects, large variations in defect resolutions, and low contrast, this paper proposes a surface defect detection method for hot‐pressed LGPs based on the PR‐YOLOv9. The poly kernel inception network (PKINet) module is integrated by replacing the second convolution module of the YOLOv9 backbone network, effectively reducing interference from invalid targets such as complex textured backgrounds, thereby enhancing the network's ability to detect multi‐scale defects and decreasing the network's parameters. Additionally, the receptive‐field attention convolutional operation (RFAConv) module is incorporated, replacing the first and last layers of the YOLOv9 backbone network with this module. RFAConv module provides attention weights for large convolution kernels, effectively improving the network's ability to extract spatial feature information. Experimental results show that the proposed PR‐YOLOv9 network achieves a mean average precision (mAP) of 98.40% and F1‐Score of 97.14% on a self‐constructed hot‐pressed LGP defect dataset, with a reduction of 6.19 M in network parameters compared with YOLOv9, representing a decrease of 10.18%, making it suitable for real‐time detection in industrial settings.
A Novel Compound Heterozygous Variant in the ABHD12 Gene Cause PHARC Syndrome in a Chinese Family: The Proband Presenting New Genotype and Phenotype
Authors: Ma Meijiao , Ma Jinhai , Lian Yuanyuan , Wu Xueli , Wang Wenming , Rong Weining , Sheng Xunlun 
Published: February 2025

ABSTRACTBackgroundPHARC syndrome, a rare autosomal recessive neurodegenerative disorder caused by mutations in the ABHD12 gene, is characterized by demyelinating polyneuropathy, hearing loss, ataxia, retinitis pigmentosa (RP), and early‐onset cataracts. If patients are first diagnosed in the ophthalmology department, they are easily misdiagnosed as having RP or Usher syndrome. This study aimed to identify the genetic etiology and determine the clinical diagnosis of a Chinese family with suspected PHARC syndrome.MethodComprehensive ophthalmic examinations and systemic evaluations were conducted to confirm the phenotype. The genotype was identified through Whole Exome Sequencing (WES), and the current literature was reviewed understand better manifestations of PHARC syndrome related to pathogenic variants.ResultsThe principal symptoms of the proband comprised profound sensorineural hearing loss since childhood, severe visual impairment, congenital cataracts, cone‐rod dystrophy, and ataxia. WES revealed that the proband carried a compound heterozygous variant in the ABHD12 gene: M1, a known nonsense variation c.477G > A (p.Trp159Ter); and M2, a novel copy number variant with a deletion of approximately 18.10 Kbp in chromosome 20p11.21 (seq[GRCh38]del(20) (p11.21)chr20:g. 25302218_25320318del), covering exons 4–12 of the ABHD12 gene. The literature review indicated that there were 65 patients with PHARC from 30 different families. All clinical information of the described patients with PHARC syndrome and all known mutations associated with the disease to date were compiled.ConclusionThis study expands the spectrum of pathogenic variants and phenotype for PHARC syndrome and suggests genetic testing is necessary for a definitive diagnosis of PHARC syndrome.
Navigating human–plant reciprocity: Commercial harvesting by professionals of a medicinal plant fosters multi‐actor landscape management
Authors: Locqueville Jonathan , McKey Doyle , MacDonald Kenneth Iain , Coq Sylvain , Caillon Sophie 
Published: February 2025

Abstract

Studies of human–nature relationships increasingly recognise not only nature's contributions to people but also the positive contributions of human practices to ecosystems. The concept of reciprocal contributions emphasises positive human–nature relationships. But trade‐offs between natural elements implies that human favouring of one element (e.g. via the protection of its habitat) can be detrimental to others. Discussing the concept of reciprocal contributions encourages us to rethink human management of landscape by shifting from a primary focus on instrumental values associated with plant extraction, to relational values related to the multiple interests of human and non‐human actors.

To study how relational values are integrated into the configuration of multifunctional landscapes, we focused on professional harvesters of Arnica montana. We asked what role professional harvesters play in the stewardship of their harvesting sites through reciprocal relations with plants, landscapes and other actors to shape the future of plant and landscape sustainability.

We show that even though professional harvesters live far from their harvesting sites, they develop both a strong attachment to them, and an experience‐based ecological knowledge of the relationships between arnica and other plant species and the environment. This attachment and experience‐based knowledge provide harvesters with legitimacy in the eyes of other actors (e.g. cattle farmers, managers of natural areas, pharmaceutical and cosmetic laboratories) and allow them to play the role of mediator between these other actors and the harvested plant in order to influence the management of the environment—for example by burning, mowing or grazing. This creates a reciprocal benefit with this particular species, but also with other co‐occurring species. Integrating the interests of the harvesters with those of other stakeholders requires negotiation and the search for synergies between values.

Synthesis and applications. Within the framework of ‘reciprocal contributions’, we argue that human engagement in reciprocal relations with specific species is read as a form of care that privileges the maintenance of certain lives over others; trade‐offs between plants but also between plants, animals, landscape and humans have to be incorporated in the theoretical framework.

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Interpenetrating Polymer Networks in Biomedical Fields: Recent Advanced and Applications
Authors: Shahi Farangis , Zarei Sara , Salah Othman Razhan , Afshar Hana , Kamran Farimah , Afshar Taromi Arsia , Khonakdar Hossein Ali 
Published: February 2025

ABSTRACTRecent developments in polymer materials have led to an increased implementation of hydrogels in biomedical settings, especially in the creation of smart hydrogels. Traditional single‐network hydrogels often exhibit challenges, such as poor mechanical strength, insufficient biocompatibility, and slow response rates. To address these issues, researchers have introduced Interpenetrating Polymer Network (IPN) hydrogels, which significantly improve mechanical strength via topological entanglements and physical interactions. This dual‐network design not only enhances biocompatibility but also responsiveness to stimuli, endowing the hydrogels with distinctive properties like cell adhesion, conductivity, hemostatic functions, antioxidant abilities, and color‐changing properties. The purpose of this article is to elucidate the factors that trigger stimuli responsiveness in IPN hydrogels, their impacts on cellular behavior, and the various biomedical applications they can serve. A comprehensive overview is provided regarding their classification, mechanisms, performance attributes, and related subjects. Ultimately, this review emphasizes the promise that smart IPN hydrogels hold in fulfilling the increasing need for innovative materials with improved mechanical features and biocompatibility in the biomedical sector.