bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of structural lesions of the sacroiliac joints in patients with spondyloarthritis: A comparison of T1-weighted 3D spoiled gradient echo MRI and MRI-based synthetic CT versus T1-weighted turbo spin echo MRI
Authors: Krabbe Simon , Møller Jakob M. , Hadsbjerg Anna E. F. , Ewald Anne , Hangaard Stine , Pedersen Susanne J. , Østergaard Mikkel 
Published: April 2024

AbstractObjectivesTo investigate the detection of erosion, sclerosis and ankylosis using 1 mm 3D T1-weighted spoiled gradient echo (T1w-GRE) MRI and 1 mm MRI-based synthetic CT (sCT), compared with conventional 4 mm T1w-TSE.Materials and methodsProspective, cross-sectional study. Semi-coronal 4 mm T1w-TSE and axial T1w-GRE with 1.6 mm slice thickness and 0.8 mm spacing between overlapping slices were performed. The T1w-GRE images were processed into sCT images using a commercial deep learning algorithm, BoneMRI. Both were reconstructed into 1 mm semi-coronal images. T1w-TSE, T1w-GRE and sCT images were assessed independently by 3 expert and 4 non-expert readers for erosion, sclerosis and ankylosis. Cohen’s kappa for inter-reader agreement, exact McNemar test for lesion frequencies and Wilcoxon signed-rank test for confidence in lesion detection were used.ResultsNineteen patients with axial spondyloarthritis were evaluated. T1w-GRE increased inter-reader agreement for detecting erosion (kappa 0.42 vs 0.21 in non-experts), increased detection of erosion (57 vs 43 of 152 joint quadrants) and sclerosis (26 vs 17 of 152 joint quadrants) among experts, and increased reader confidence for scoring erosion and sclerosis. sCT increased inter-reader agreement for detecting sclerosis (kappa 0.69 vs 0.37 in experts) and ankylosis (0.71 vs 0.52 in non-experts), increased detection of sclerosis (34 vs 17 of 152 joint quadrants) and ankylosis (20 vs 13 of 76 joint halves) among experts, and increased reader confidence for scoring erosion, sclerosis and ankylosis.ConclusionT1w-GRE and sCT increase sensitivity and reader confidence for the detection of erosion, sclerosis and ankylosis, compared with T1w-TSE.Clinical relevance statementThese methods improve the detection of sacroiliac joint structural lesions and might be a useful addition to SIJ MRI protocols both in routine clinical care and as structural outcome measures in clinical trials.
Computed tomography in patients with sepsis presenting to the emergency department: exploring its role in light of patient outcomes
Authors: Pohlan Julian , Möckel Martin , Slagman Anna , Tenenbaum Hannah , Stolz Jules , Rubarth Kerstin , Winning Johannes , Bauer Michael , Reinhart Konrad , Stacke Angelika , Dewey Marc , Bolanaki Myrto 
Published: April 2024

Abstract
Objectives
This study aimed to explore the role of CT in septic patients presenting to the emergency department (ED).

Materials and methods
We performed a retrospective secondary analysis of 192 septic patients from a prospective observational study, i.e., the “LIFE POC” study. Sepsis was diagnosed in accordance with the Sepsis-3 definition. Clinical and radiological data were collected from the hospital administration and radiological systems. Information on mortality and morbidity was collected. Time-to-CT between CT scan and sepsis diagnosis (ttCTsd) was calculated. Diagnostic accuracy was assessed with the final sepsis source as reference standard. The reference standard was established through the treating team of the patient based on all available clinical, imaging, and microbiological data.

Results
Sixty-two of 192 patients underwent a CT examination for sepsis focus detection. The final septic source was identified by CT in 69.4% (n = 43). CT detected septic foci with 81.1% sensitivity (95% CI, 68.0–90.6%) and 55.6% specificity (95% CI, 21.2–86.3%). Patients with short versus long ttCTsd did not differ in terms of mortality (16.1%, n = 5 vs 9.7, n = 3; p = 0.449), length of hospital stay (median 16 d, IQR 9 d 12 h–23 d 18 h vs median 13 d, IQR 10 d 00 h–24 d 00 h; p = 0.863), or duration of intensive care (median 3d 12 h, IQR 2 d 6 h–7 d 18 h vs median 5d, IQR 2 d–11 d; p = 0.800).

Conclusions
Our findings show a high sensitivity of CT in ED patients with sepsis, confirming its relevance in guiding treatment decisions. The low specificity suggests that a negative CT requires further ancillary diagnostic tests for focus detection. The timing of CT did not affect morbidity or mortality outcomes.

Clinical relevance statement
In patients with sepsis who present to the ED, CT can be used to identify infectious foci on the basis of clinical suspicion, but should not be used as a rule-out test. Scientific evidence for the optimal timing of CT beyond clinical decision-making is currently missing, as potential mortality benefits are clouded by differences in clinical severity at the time of ED presentation.

Key Points
• In patients with sepsis who present to the ED, CT for focus identification has a high sensitivity and can thereby be valuable for patient management.
• As the specificity is considerably lower, a thorough microbiological assessment is important in these cases.
• The timing of CT did not affect morbidity and mortality outcomes in this study, which might be due to variability in clinical severity at the time of ED presentation.
Inactivation Pathway of Diterpenoid Regulator in the Moss Physcomitrium patens
Authors: Miyazaki Sho , Kawaide Hiroshi , Nakajima Masatoshi 
Published: April 2024

AbstractThe endogenous levels of plant hormones, including gibberellins (GAs), are strictly regulated and maintained during growth and development in seed plants. The regulation of endogenous levels of bioactive GAs is mediated by the mechanisms of their biosynthesis and inactivation. The moss Physcomitrium patens harbors a partial GA biosynthetic pathway from geranylgeranyl diphosphate to ent-kaurenoic acid (KA). Recently, we have identified ent-3β-hydroxy kaurenoic acid (3OH-KA) as a biologically active metabolite of KA to control the protonemal cell differentiation. In addition, ent-2α-hydroxy kaurenoic acid catalyzed by KA 2-oxidase (KA2ox) was also identified as inactive product. Although the activation and inactivation pathways from KA have been identified, the inactivation pathway of 3OH-KA remains to be elucidated. Considering the GA inactivation mechanism of flowering plants, in which GA2ox hydroxylates the C-2 position of GAs as part of the biosynthetic pathway, it was presumed that 3OH-KA was converted to 2,3-dihydroxy KA by PpKA2ox; however, this work shows that PpKA2ox undergoes hydroxylation at the C-16 position to synthesize a new compound ent-3β,16β-dihydroxy kaurenoic acid (3,16diOH-KA) from 3OH-KA. The protonemal cell differentiation activity of 3,16diOH-KA was low, and 3,16diOH-KA was detected in wild-type strains. These results indicate that 3,16diOH-KA was the major inactivating metabolite of 3OH-KA.
Common soil history is more important than plant history for arbuscular mycorrhizal community assembly in an experimental grassland diversity gradient
Authors: Albracht Cynthia , Solbach Marcel Dominik , Hennecke Justus , Bassi Leonardo , van der Ploeg Geert Roelof , Eisenhauer Nico , Weigelt Alexandra , Buscot François , Heintz-Buschart Anna 
Published: April 2024

AbstractThe relationship between biodiversity and ecosystem functioning strengthens with ecosystem age. However, the interplay between the plant diversity - ecosystem functioning relationship and Glomeromycotinian arbuscular mycorrhizal fungi (AMF) community assembly has not yet been scrutinized in this context, despite AMF’s role in plant survival and niche exploration. We study the development of AMF communities by disentangling soil- and plant-driven effects from calendar year effects. Within a long-term grassland biodiversity experiment, the pre-existing plant communities of varying plant diversity were re-established as split plots with combinations of common plant and soil histories: split plots with neither common plant nor soil history, with only soil but no plant history, and with both common plant and soil history. We found that bulk soil AMF communities were primarily shaped by common soil history, and additional common plant history had little effect. Further, the steepness of AMF diversity and plant diversity relationship did not strengthen over time, but AMF community evenness increased with common history. Specialisation of AMF towards plant species was low throughout, giving no indication of AMF communities specialising or diversifying over time. The potential of bulk soil AMF as mediators of variation in plant and microbial biomass over time and hence as drivers of biodiversity and ecosystem relationships was low. Our results suggest that soil processes may be key for the build-up of plant community-specific mycorrhizal communities with likely feedback effects on ecosystem productivity, but the plant-available mycorrhizal pool in bulk soil itself does not explain the strengthening of biodiversity and ecosystem relationships over time.
Long-term results of etiology-based thoracic endovascular aortic repair: a single-center experience
Authors: Takazawa Akitoshi , Asakura Toshihisa , Nakazawa Ken , Kinoshita Osamu , Nakajima Hiroyuki , Yoshitake Akihiro 
Published: April 2024

AbstractThe use of thoracic endovascular aortic repair (TEVAR) for thoracic aortic aneurysm (TAA) and Stanford type B aortic dissection (TBAD) has been increasing; however, in terms of etiology, the differences of long term after TEVAR outcomes remain unexplored. Thus, we investigated etiology-specific long-term results of TEVAR for TAA and TBAD. A total of 421 TEVAR procedures were performed at our institution from July 2007 to December 2021; 249 TAA cases and 172 TBAD cases were included. Traumatic aortic dissection and aortic injury cases were excluded. The mean observation duration was 5.7 years. The overall 30-day mortality rate was 1.4% (n = 6), with 1.2% (n = 3) in the TAA group and 1.7% (n = 3) in the TBAD group. The overall incidence of postoperative stroke was 0.9% (n = 4), with 1.2% (n = 3) and 0.6% (n = 1) in the TAA and TBAD groups, respectively (p = 0.90). Paraplegia developed in 1.7% (n = 7) of patients, with 2.4% (n = 6) in the TAA group and 0.6% (n = 1) in the TBAD group. Freedom from aortic-related death was not significantly different between the two etiologies; however, thoracic reintervention was more common in the TBAD group (p = 0.003), with endoleak being the most common indication for reintervention. Additionally, retrograde type A aortic dissection occurred in four TBAD cases, while migration occurred in three TAA cases. The perioperative results of TEVAR for TAA and TBAD were satisfactory. The long-term results were unfavorable owing to the occurrence of etiology-specific and common complications. In terms of the high frequency of reintervention, the long-term complications associated with TEVAR are etiology specific.
Common and specific activations supporting optic flow processing and navigation as revealed by a meta-analysis of neuroimaging studies
Authors: Sulpizio Valentina , Teghil Alice , Pitzalis Sabrina , Boccia Maddalena 
Published: April 2024

AbstractOptic flow provides useful information in service of spatial navigation. However, whether brain networks supporting these two functions overlap is still unclear. Here we used Activation Likelihood Estimation (ALE) to assess the correspondence between brain correlates of optic flow processing and spatial navigation and their specific neural activations. Since computational and connectivity evidence suggests that visual input from optic flow provides information mainly during egocentric navigation, we further tested the correspondence between brain correlates of optic flow processing and that of both egocentric and allocentric navigation. Optic flow processing shared activation with egocentric (but not allocentric) navigation in the anterior precuneus, suggesting its role in providing information about self-motion, as derived from the analysis of optic flow, in service of egocentric navigation. We further documented that optic flow perception and navigation are partially segregated into two functional and anatomical networks, i.e., the dorsal and the ventromedial networks. Present results point to a dynamic interplay between the dorsal and ventral visual pathways aimed at coordinating visually guided navigation in the environment.
Perspectives of refugee parents and unaccompanied minors on initial health assessment and access to care
Authors: Baauw Albertine , Brouwers Chanine F. S. , Afshar Sogol Fathi , van Goudoever Johannes B. , Chinapaw Mai J. M. , Hoogsteder Mariëtte H. H. 
Published: April 2024

AbstractTo explore the needs, expectations, and experiences of asylum-seeking parents and unaccompanied minors under the age of 18 years on the initial health assessment for children and adolescents and access to care upon entry in the Netherlands, We conducted five semi-structured focus group discussions with asylum-seeking parents and unaccompanied minors, from Syria, Eritrea, Afghanistan, and other Middle-East and African countries, supported by professional interpreters. To triangulate findings, semi-structured interviews with health care professionals involved in care for refugee children were conducted. Transcripts of focus group discussions were inductively and deductively coded and content analyzed; transcripts of interviews were deductively coded and content analyzed. In total, 31 asylum-seeking participants: 23 parents of 101 children (between 0 and 18 years old), 8 unaccompanied minors (between 15 and 17 years), and 6 healthcare professionals participated. Parents and minors expressed that upon entry, their needs were met for vaccinations, but not for screening or care for physical and mental health problems. Parents, minors, and health professionals emphasized the necessity of appropriate information and education about health, diseases, and the health system. Cultural change was mentioned as stressful for the parent–child interaction and parental well-being. Conclusion: The perspectives of refugee parents and unaccompanied minors revealed opportunities to improve the experience of and access to health care of refugees entering the Netherlands, especially risk-specific screening and more adequate education about health, diseases, and the Dutch health care system.

What is Known:• Refugees have specific health needs due to pre-flight, flight, and resettlement conditions. Health assessment upon entry was non-obligatory in the Netherlands, except for the tuberculosis screening. Health needs were not always met, and refugees experienced barriers in access to care.

What is New:• The initial health assessment met the needs concerning vaccinations but mismatched the needs regarding physical and mental health assessment. Screening for specific risk-related diseases and mental health could enable refugee parents and minors to engage better with the health system.
Why all newborn hip screening programs have same results—a mini review
Authors: BM Matias Vaajala , Pakarinen Oskari , Helenius Ilkka , Uimonen Mikko M , Ponkilainen Ville T , Kuitunen Ilari 
Published: April 2024

AbstractAll newborns are screened for developmental dysplasia of the hip (DDH), but countries have varying screening practices. The aim of this narrative mini review is to discuss the controversies of the screening and why it seems that all screening programs are likely to have same outcome. Different screening strategies are discussed alongside with other factors influencing DDH in this review. Universal ultrasound (US) has been praised as it finds more immature hips than clinical examination, but it has not been proven to reduce the rates of late-detected DDH or surgical management. Universal US screening increases initial treatment rates, while selective US and clinical screening have similar outcomes regarding late detection rates than universal US. This can be explained by the extrinsic factor affecting the development of the hip joint after birth and thus initial screening during the early weeks cannot find these cases. Conclusion: It seems that DDH screening strategies have strengths and limitations without notable differences in the most severe outcomes (late-detected cases requiring operative treatment). Thus, it is important to acknowledge that the used screening policy is a combination of values and available resources rather than a decision based on clear evidence.
Comparison of the efficacy of enfortumab vedotin between patients with metastatic urothelial carcinoma who were treated with avelumab or pembrolizumab: real-world data from a multi-institutional study in Japan
Authors: Hirasawa Yosuke , Adachi Takahiro , Hashimoto Takeshi , Fukuokaya Wataru , Koike Yuhei , Yata Yuji , Komura Kazumasa , Uchimoto Taizo , Tsujino Takuya , Nishimura Kazuki , Takahara Kiyoshi , Saruta Masanobu , Fujita Kazutoshi , Hashimoto Mamoru , Uemura Hirotsugu , Shiroki Ryoichi , Azuma Takashi , Kimura Takahiro , Ohno Yoshio 
Published: April 2024

Abstract
Objectives
Enfortumab vedotin (EV) is a novel antibody–drug conjugate approved for metastatic urothelial carcinoma (UC) refractory to prior treatment with immune checkpoint inhibitors (ICIs). However, the difference in efficacy of EV after each ICIs and prognostic factors are not well known. We aimed to compare the efficacy of EV in patients with metastatic UC who were treated with avelumab or pembrolizumab and to identify the prognostic factors.

Methods
The records of 100 patients with advanced metastatic UC who received EV after the administration of either avelumab or pembrolizumab were retrospectively collected from five academic hospitals in Japan.

Results
The median follow-up period was 6.7 months. The median overall survival (OS) and progression-free survival (PFS) in the EV after avelumab/pembrolizumab group were not reached/14.7 months (p = 0.17) and 10.4/5.2 months (p = 0.039), respectively. The objective response rates (ORR) were 66.6% and 46.8% in EV after avelumab and EV after pembrolizumab groups, respectively (p = 0.14). Multivariate analysis identified histological variants, liver metastasis, low serum albumin levels, and high serum CRP level as significant poor prognostic factors. The median OS and PFS of cachexia patients with both low serum albumin levels and high serum CRP levels were 6.0 months and 0.93 months, respectively.

Conclusion
PFS was superior in patients treated with EV after avelumab to EV after pembrolizumab. However, OS showed no significant difference between the two groups. Because the prognosis of patients with cachexia is extremely poor, the initiation of EV should be discussed in these patients.
Clinical and neuroimaging characterization of the first frontotemporal dementia family carrying the MAPT p.K298E mutation
Authors: Pozzi Federico Emanuele , Aprea Vittoria , Giovannelli Ginevra , Lattuada Francesca , Crivellaro Cinzia , Bertola Francesca , Castelnovo Veronica , Canu Elisa , Filippi Massimo , Appollonio Ildebrando , Ferrarese Carlo , Agosta Federica , Tremolizzo Lucio 
Published: April 2024

AbstractWe present an in-depth clinical and neuroimaging analysis of a family carrying the MAPT K298E mutation associated with frontotemporal dementia (FTD). Initial identification of this mutation in a single clinical case led to a comprehensive investigation involving four affected siblings allowing to elucidate the mutation's phenotypic expression.A 60-year-old male presented with significant behavioral changes and progressed rapidly, exhibiting speech difficulties and cognitive decline. Neuroimaging via FDG-PET revealed asymmetrical frontotemporal hypometabolism. Three siblings subsequently showed varied but consistent clinical manifestations, including abnormal behavior, speech impairments, memory deficits, and motor symptoms correlating with asymmetric frontotemporal atrophy observed in MRI scans.Based on the genotype–phenotype correlation, we propose that the p.K298E mutation results in early-onset behavioral variant FTD, accompanied by a various constellation of speech and motor impairment.This detailed characterization expands the understanding of the p.K298E mutation's clinical and neuroimaging features, underlining its role in the pathogenesis of FTD. Further research is crucial to comprehensively delineate the clinical and epidemiological implications of the MAPT p.K298E mutation.
Processing of metal-free end-of-life tyres (EOLTs) to fuels and products: an experimental study with process simulation and economic analysis from an Australian perspective
Authors: Kibria Mahmud Arman , Thomas Bennet Sam , Bhattacharya Mita , Bhattacharya Sankar 
Published: April 2024

AbstractThe aim of this experimental study, process simulation and economic analysis is to assess the applicability of pyrolysis technology for processing end-of-life tyres and to evaluate the economic viability of a 60 ton/day EOLT processing facility: a case-specific study within Australia. The experimental work and characterization of feedstock and products were carried out in-house. Capital costs for major equipment were collected from suppliers. The running cost of the processing facility is calculated on the basis of the current labour and utility costs. An economic model is developed based on the information generated from the experimental program and those obtained from suppliers. From the analysis, it is evident that the pyrolysis process for processing EOLT promises a significant upside in economic terms. A conservative conclusion of 20% light oil, ~ 65% furnace oil and 7% carbon black, generated as pyrolysis products, depicts a cash-flow positivity for a 60 tonne per day (TPD) plant that can be run using the generated fuel gas for under 4 years. This is in addition to the benefit of the zero landfill requirement. Apart from the base calculations, the sensitivity of six different scenarios is analysed by mainly changing the land cost and bank investment. Depending on the scenario, the calculated internal rate of return varies between 15 and 35%. While Australia generates significant quantities of EOLT, the techno-economic results confirm that pyrolysis technology for processing EOLT is a viable solution in Australia. However, a dedicated supply chain needs to exist to make pyrolysis plants an attractive investment at defined locations.
Graphical abstract
Cross section sensitivity to perturbation strengths in distorted waves for double electron capture by alpha particles from helium targets
Authors: Belkić Dževad 
Published: April 2024

AbstractComputer experiments are performed on total cross sections for capture of both electrons from helium targets at 100-10000 keV. Employed are four quantum-mechanical perturbative four-body distorted wave methods (one of the first and three of the second order). The goal is to determine the cross section sensitivity to the perturbation strengths in distorted waves from the second-order methods. The perturbation strength is parametrized by the Sommerfeld factor (the quotient of the nuclear charge and the relative velocity of the colliding particles). At each fixed impact energy, the sought sensitivity is monitored by gradually modifying the nuclear charges in the Sommerfeld factors. These factors reside in the Coulomb distortions of the unperturbed channels states. The focus is on the electronic distortions through the eikonal Coulomb logarithmic phases and the full Coulomb waves. The logarithmic phases are the constituents of the compound phases for the net charges of the two heavy scattering aggregates in relative motions. A striking perturbation strength sensitivity of the obtained total cross sections is recorded.