bluuebunny/crossref_metadata_2025_split huggingface dataset:
Экономикадағы жаһандық үрдіс және орнықты даму: әлемдік тенденциялар мен отандық тәжірибе
Authors: Кадыров Б. , Искаков Б. , Кадринов М. 
Published: April 2024

Ұсынылып отырған ғылыми мақалада ғалымдардың, түрлі экономикалық мектептердің, халықаралық беделді ұйымдардың ғылыми еңбектері оқып - зерттеп, қазіргі қолданыстағы нарықтық сипаттағы дәстүрлі экономикалық үлгінің даму шегіне жетіп, экологиялық факторларды ескере отырыра орнықты дамуға көшудің жаңа модельдерін енгізіп одан әрі дамытудан басқа балама жоқ екені анықталған. ХХІ ғасырдағы әлемдік тәртіптің архитектурасын қалыптастыру елдер, компаниялар арасындағы бәсекелестіктің өсіп келе жатқан күрделі процестерінің үйлесімі негізінде жүретіндігіне назар аударылған.
Бүгінде, дәстүрлі макро көрсеткіштер адамның әл-ауқатының өлшемі болып қала берсе, өзгеріс жолында үлкен кедергілер болады. Нарық тек тиімділікті көреді, ол әділеттілікті немесе тұрақтылықты сезінуге бейімделмеген. Осыған байланысты дәстүрлі экономикалық көрсеткіштерге назар аудару болашақта тұрақты дамуға көшуге кедергі келтіруі мүмкін. Өсудің ресми макроэкономикалық көрсеткіштерін емес, экологиялық және әлеуметтік мәселелерді көрсететін индикаторлар маңызды рөл атқаруы керек екендігі авторлармен нақтыланып, ұсыныстар мен жетілдіру жолдары айқындалған, жаһандық сын – қатерлерді ескере отыра отандық тәжірибеге озық үлгілерді кіріктіру мүмкіндіктері қарастырылған.
The incidence of coxiella infection in Iraqi women with early pregnancy loss
Authors: Alanbaki Noor , Baydaa Hameed Abdullah  , Wassan Abdulkarreem Abbas  , Mamdouh Mohamed Elbahnasawy  
Published: April 2024

Query fever is a bacterial disease resulting from Coxiella burnetii (CB) infection in animals. It is well known that small ruminants who get Q fever lose their babies. People think pregnant women may also have lousy gestation results if they get the infection or the infection comes back to life during pregnancy.
This study looks at how serologic results of Q fever and early pregnancy loss (EPL) are linked. In Baghdad, including Madinat Al-Imamain Al-Kadhmain Teaching Hospital and Abu Ghraib Hospital, multicenter case-control research was conducted from September to December 2022. A total of 90 women were enrolled in this investigation. Sixty clinically suffered from early pregnancy loss by having a nonviable intrauterine pregnancy. The other 30 women were subjects of comparable age, the week of pregnancy, and the healthy subjects as controls. Using a commercial enzyme-linked immunosorbent assay (ELISA), serum samples were screened for antibodies against CB. Three (5%) cases tested positive for CB by ELISA. The study reveals no association between adverse gestation outcomes and positive Q fever serology. Age and abortion history were not significantly correlated with C. burnetii seropositivity, according to the findings of CB cases that tested positive results.
Effects Of Topical Petroleum Ether and Ethyl Acetate Fractions from Grape Seed Extract on Imiquimod-Induced Psoriasis Like Skin Inflammation in Mice
Authors: Fareed Mohammed , Al-Qrimli Ayah F. 
Published: April 2024

Background: Grape seed is a natural herb with many suggested pharmacological effects related to many biologically active compounds in its extract and fractions. Grape seed pharmacological effect is investigated in mice psoriasis like model. Methods: A thirty male albino mice, six weeks’ age used in this research and were divided into five groups. Group I apparently healthy. Group II induction group, imiquimod 5% cream once daily used at the back skin of the animal for five days. Group III, IV and V treatments groups. Group III clobetasol ointment 0.05%, group IV Grape seed extract and group V Grape seed petroleum ether fraction for five days. Results: A high significant increase was found between the apparently healthy and imiquimod induced group for all of the investigated parameters except munro abscess was significant increase. For the grape seed extract group, it was found A significant difference in immunohistochemistry score of IL17, also significant decrease in vascular endothelial growth factor (VEGF) with high significant decrease of other immunohistopathology measurement like parakeratosis. Conclusion: Grape seed extract may have a role in imiquimod-induced psoriasis like skin inflammation in mice treatment which make it a future candidate therapy for psoriasis.
ПРАВОВЕ РЕГУЛЮВАННЯ ДОМЕННИХ ІМЕН: ЄВРОПЕЙСЬКИЙ ДОСВІД
Authors: Цибізова С. А. 
Published: April 2024

Стаття присвячена проблемам правового регулювання доменних імен з урахуванням європейського досвіду. Зокрема, було досліджено європейський досвід правового регулювання доменних імен та можливість його імплементації до законодавства України та правових звичаїв, що регламентують делегування доменних імен в українському сегменті мережі «Інтернет». Проведено огляд законодавства та юридичної практики щодо доменних імен у країнах романо-германської правової сім’ї на прикладі Німеччини та Франції. Виявлені проблеми, які виникають у цих європейських країнах під час розгляду доменних спорів. Проаналізовано законодавство України щодо доменних імен. Здійснено порівняльний аналіз європейського та національного правового регулювання доменних імен та запропоновано методи вдосконалення за рахунок європейського досвіду. Виявлено необхідність розробити механізми захисту майнової цінності доменних імен. Запропонована рецепція окремих норм Кодексу поштового та електронного зв’язку Кодексу інтелектуальної власності Франції. Рекомендовано Реєстр домену.UA спільно з адміністраторами та реєстраторами розробити процедуру для запобігання передачі прав на доменне ім’я протягом періоду розгляду судового спору, на кшталт здійснення запису «DISPUTE» (спір) у німецькому національному домені верхнього рівня .DЕ. У разі виникнення складнощів під час вирішення доменних спорів, які обумовлені недостатньою розробкою законодавчої бази, національним судам пропонується використовувати рішення іноземних судових установ як джерело пізнання. Отримані результати надають можливість удосконалити правове регулювання доменних імен на рівні національного законодавства, юридичної практики та звичаїв ділового обороту в мережі «Інтернет».
За результатами дослідження, запропоновано розробити спеціальний закон про доменні імена в Україні, використавши іноземний досвід. Отримані результати надають можливість удосконалити правове регулювання доменних імен на рівні національного законодавства.
Preliminary experiments on potential use of blue monochromatic light for identification of cashew diseases
Authors: Uaciquete Americo , Chamo Paulo Nel , Älvaro José Chamessanga 
Published: April 2024

Cashew is a valuable crop for the world due to its nutritional, environmental, and economic qualities. However, it is challenged by abiotic and abiotic constraints such as diseases that cause significant yield losses. Various disease diagnostic and management strategies have been developed over time. But their adequacy is bound to a complex of advantages and disadvantages depending on host/pathogen relationships. Thus, the objective of this article was to describe a new approach that distinguishes cashew diseases by light at 405 nm. Symptomatic tissues were, under aseptia, prepared for pathogen culturing and morpho cultural identification of the pathogen(s) associated. By inoculation and incubation of pathogens, disease symptoms were reproduced on cashew seedlings. Later, symptomatic tissues were then cut macerated in a 1/1(weight/water) extraction and allowed to precipitate at 4 oC. The supernatant was submitted to absorbance reading in a monochromatic beam of 405 nm. Sole extraction water and sole healthy tissue extracts were also considered. Three experiments with different treatments were conducted. Absorbance data were then processed statistically following a completely randomized design in which treatments consisted of individual plant/pathogen(s) extracts. The biotrophic pathogen O. anacardii resulted in the highest absorbance. However, it reduced in association with the necrotrophic pathogen Cryptosporipsis spp. No significant differences were discovered between the two necrotrophic pathogens Cryptosporipsis spp. and Septoria spp. The method demonstrated high potential for diagnosis of cashew diseases. Future research must focus on adjustable wavelength spectrophotometry and standardization. The method can be recommended for direct identification of field disease samples.
Exploring the multifaceted bioactivities of Lavandula pinnata L. essential oil: promising pharmacological activities
Authors: Haddou Mounir , Elbouzidi Amine , Taibi Mohamed , Baraich Abdellah , Loukili El Hassania , Bellaouchi Reda , Saalaoui Ennouaamane , Asehraou Abdeslam , Salamatullah Ahmad Mohammad , Bourhia Mohammed , Nafidi Hiba-Allah , Addi Mohamed , Guerrouj Bouchra El , Chaabane Khalid 
Published: April 2024

Introduction: This study investigates the biological activities of Lavandula pinnata essential oil (LPEO), an endemic lavender species from the Canary Islands, traditionally used in treating various ailments.Methods: LPEO was extracted by hydrodistillation and analyzed using GC-MS. Antioxidant activity was assessed by DPPH radical scavenging and total antioxidant capacity assays. Antimicrobial activity was evaluated by disc diffusion, MIC, MBC, and MFC determination against bacterial (Staphylococcus aureus, Micrococcus luteus, Escherichia coli, Pseudomonas aeruginosa) and fungal (Candida glabrata, Rhodotorula glutinis, Aspergillus niger, Penicillium digitatum) strains. Antidiabetic and anti-gout potential were investigated through α-amylase, α-glucosidase, and xanthine oxidase inhibition assays. Antityrosinase activity was determined using a modified dopachrome method. Cytotoxicity was assessed by MTT assay against breast (MCF-7, MDA-MB-468), liver (HepG2), colon (HCT-15) cancer cells, and normal cells (PBMCs).Results and discussion: LPEO exhibits potent antiradical activity (IC50 = 148.33 ± 2.48 μg/mL) and significant antioxidant capacity (TAC = 171.56 ± 2.34 μg AA/mg of EO). It demonstrates notable antibacterial activity against four strains (Staphylococcus aureus, Micrococcus luteus, Escherichia coli, and Pseudomonas aeruginosa) with inhibition zones ranging from 18.70 ± 0.30 mm to 29.20 ± 0.30 mm, along with relatively low MIC and MBC values. LPEO displays significant antifungal activity against four strains (Candida glabrata, Rhodotorula glutinis, Aspergillus niger, and Penicillium digitatum) with a fungicidal effect at 1 mg/mL, surpassing the positive control (cycloheximide), and MIC and MFC values indicating a fungicidal effect. It exhibits substantial inhibition of xanthine oxidase enzyme (IC50 = 26.48 ± 0.90 μg/mL), comparable to allopurinol, and marked inhibitory effects on α-amylase (IC50 = 31.56 ± 0.46 μg/mL) and α-glucosidase (IC50 = 58.47 ± 2.35 μg/mL) enzymes.The enzyme tyrosinase is inhibited by LPEO (IC50 = 29.11 ± 0.08 mg/mL). LPEO displays moderate cytotoxic activity against breast, liver, and colon cancer cells, with low toxicity towards normal cells (PBMC). LPEO exhibits greater selectivity than cisplatin for breast (MCF-7) and colon (HCT-15) cancer cells but lower selectivity for liver (HepG2) and metastatic breast (MDA-MB-468) cancer cells. These findings suggest the potential of LPEO as an antioxidant, antimicrobial, anti-gout, antidiabetic, and anticancer agent.
Development and feasibility assessment of a virtual reality-based aerobic exercise program with real-time pulse rate monitoring on hemodynamic and arterial stiffness in healthy people: a pilot study
Authors: Yuenyongchaiwat Kornanong , Sermsinsathong Natsinee , Songsorn Preeyaphorn , Charususin Noppawan , Buranapuntalug Sasipa , Buekban Chatchai , Thanawattano Chusak 
Published: April 2024

IntroductionVirtual reality (VR) exercises are reportedly beneficial as a physical activity tool for health promotion and rehabilitation, and can also help individuals exercise under professional supervision. We developed and investigated the potential feasibility of a VR-based aerobic exercise program using the XBOX ONE console and Kinect sensor with real-time pulse rate monitoring. The VR setting consisted of two-dimensional (2D) environments via computer, laptop, or television screens. In addition, the study investigated the potential feasibility of the VR-based exercise program on hemodynamic response and arterial stiffness in healthy participants of various ages.MethodsHealthy participants (n = 30) aged &gt; 18 years were enrolled in the VR exercise-based program. All participants were required to wear a polar heart rate (HR) monitor set for moderate-intensity exercise, targeting 40%–59% of their HR reserve. Hemodynamic and arterial stiffness (pulse wave velocity) were noninvasively measured. The Borg scale rate of perceived exertion (RPE) was also assessed.ResultsFollowing a VR-guided exercise routine, all participants performed moderate-intensity exercise with no adverse health outcomes during or after the exercise. The effects of VR-based aerobic exercise extended beyond enhanced central hemodynamic and arterial stiffness. However, neither hemodynamic nor arterial stiffness showed significant differences before and after the VR exercise, except for a higher RPE response following the exercise program.ConclusionVR-based aerobic exercise with pulse rate monitoring is a promising physical activity tool to induce physiological changes and impact dyspnea scales and is also feasible for administration to healthy populations.
Effect of perceived stress, job satisfaction, and workload on the professional self-efficacy of Peruvian regular basic education teachers
Authors: Belizario Marleni Velez , Mamani-Benito Oscar , Zerga-Morales Carlos Alejandro , Turpo-Chaparro Josué E. , Morales-García Wilter C. 
Published: April 2024

IntroductionThe COVID-19 pandemic has had repercussions on teachers’ beliefs about their efficacy in their profession. In light of this, the aim of this study was to determine the effect of perceived stress, job satisfaction, and workload on professional self-efficacy among Peruvian regular basic education teachers.MethodThis was a cross-sectional explanatory study involving 687 regular basic education teachers (57.6% women) aged between 23 and 55 years (M = 38.15, SD = 8.58), from both private and public institutions across the three regions of Peru (coastal, jungle and highland). The instruments used were the Professional Self-Efficacy Questionnaire (AU-10), the Perceived Stress Scale related to the pandemic (EEP-10), the Affective Job Satisfaction Scale (BIAJS), and the Workload Scale (ECT).ResultsA SEM analysis was conducted, yielding satisfactory goodness-of-fit indices: χ2 = 87.028, p = 0.000, with 11 df, CFI = 0.993, RMSEA = 0.047, and SRMR = 0.021. This confirmed H1, as there is a negative effect of workload on professional self-efficacy (β = −0.11, p = 0.017). Similarly, H2 was confirmed, as there is a positive effect of job satisfaction on professional self-efficacy (β = 0.13, p = 0.003). However, H3 was rejected, as no significant effect of perceived stress on professional self-efficacy was evident (β = −0.02, p = 0.658).ConclusionWorkload and job satisfaction explain the perceived level of self-efficacy among Peruvian regular basic education teachers. However, there is no evidence to suggest that stress affects their sense of efficacy.
Genetic architecture of post-harvest tuber quality traits in bush yam (Dioscorea praehensilis Benth.) germplasm through association mapping
Authors: Adewumi Adeyinka S. , Asare Paul A. , Akintayo Oluyemi Titilola , Adejumobi Idris I. , Adu Michael O. , Taah Kingsley J. , Afutu Emmanuel , Opoku Vincent A. , Stanley Adekemi E. , Akaba Selorm , Mondo Jean M. , Mushoriwa Hapson , Agre Paterne A. 
Published: April 2024

IntroductionBush yam (Dioscorea praehensilis Benth.) is an important semi-domesticated food crop in West Africa. Limited information on the genetic architecture and its poor post-harvest tuber quality traits significantly hinder its use as food and source of income. Hence, dissecting the genetics underlying the expression of its post-harvest tuber quality traits is essential for establishing proper breeding schemes.MethodsIn this study, 138 D. praehensilis accessions collected in Ghana were sequenced using Diversity Array Technology (DArTSeq). The materials were profiled for dry matter content (DMC), tuber flesh oxidation (TBOXI) and for tuber flesh hardness (TBhard) during two cropping seasons.Results and discussionDiversity assessment using population structure, principal component analysis and hierarchical clustering methods revealed the presence of three major groups. Six genetic models were used for the trait association analysis using multiple random locus mixed linear model (MrMLM). Sixteen SNP markers distributed across the yam genome were identified to be associated with the evaluated traits. The associated SNP markers displayed a phenotypic variance ranged from 4.22% in TBHard to 16.92% in TBOXI. A total 25 putative candidate genes were identified around the SNP markers. The putative genes were identified to play key roles in tuber bulking, oxidative browning and starch hydroxylase. This study provides a valuable insight on the genetics underlying tuber quality traits in bush yam and opens avenues for developing genomic resources to improve D. praehensilis.
Identification of a distinct cluster of GDF15high macrophages induced by in vitro differentiation exhibiting anti-inflammatory activities
Authors: Dai Chaochao , Zhang Hongyu , Zheng Zhijian , Li Chun Guang , Ma Mingyuan , Gao Haiqing , Zhang Qunye , Jiang Fan , Cui Xiaopei 
Published: April 2024

IntroductionMacrophage-mediated inflammatory response may have crucial roles in the pathogenesis of a variety of human diseases. Growth differentiation factor 15 (GDF15) is a cytokine of the transforming growth factor-β superfamily, with potential anti-inflammatory activities. Previous studies observed in human lungs some macrophages which expressed a high level of GDF15.MethodsIn the present study, we employed multiple techniques, including immunofluorescence, flow cytometry, and single-cell RNA sequencing, in order to further clarify the identity of such GDF15high macrophages.ResultsWe demonstrated that macrophages derived from human peripheral blood mononuclear cells and rat bone marrow mononuclear cells by in vitro differentiation with granulocyte-macrophage colony stimulating factor contained a minor population (~1%) of GDF15high cells. GDF15high macrophages did not exhibit a typical M1 or M2 phenotype, but had a unique molecular signature as revealed by single-cell RNA sequencing. Functionally, the in vitro derived GDF15high macrophages were associated with reduced responsiveness to pro-inflammatory activation; furthermore, these GDF15high macrophages could inhibit the pro-inflammatory functions of other macrophages via a paracrine mechanism. We further confirmed that GDF15 per se was a key mediator of the anti-inflammatory effects of GDF15high macrophage. Also, we provided evidence showing that GDF15high macrophages were present in other macrophage-residing human tissues in addition to the lungs. Further scRNA-seq analysis in rat lung macrophages confirmed the presence of a GDF15high sub-population. However, these data indicated that GDF15high macrophages in the body were not a uniform population based on their molecular signatures. More importantly, as compared to the in vitro derived GDF15high macrophage, whether the tissue resident GDF15high counterpart is also associated with anti-inflammatory functions remains to be determined. We cannot exclude the possibility that the in vitro priming/induction protocol used in our study has a determinant role in inducing the anti-inflammatory phenotype in the resulting GDF15high macrophage cells.ConclusionIn summary, our results suggest that the GDF15high macrophage cells obtained by in vitro induction may represent a distinct cluster with intrinsic anti-inflammatory functions. The (patho)physiological importance of these cells in vivo warrants further investigation.
Identification of mulberry leaf flavonoids and evaluating their protective effects on H2O2-induced oxidative damage in equine skeletal muscle satellite cells
Authors: Zhang Xinzhuang , Geng Aopan , Cao Di , Dugarjaviin Manglai 
Published: April 2024

Introduction: Horses are susceptible to oxidative stress during strenuous endurance exercise, leading to muscle fatigue and damage. Mulberry leaf flavonoids (MLFs) possess significant antioxidant properties. However, the antioxidant efficacy of MLFs can be influenced by the extraction process, and their impact on H2O2-induced oxidative stress in equine skeletal muscle satellite cells (ESMCs) remains unexplored.Methods: Our study employed three extraction methods to obtain MLFs: ultrasound-assisted extraction (CEP), purification with AB-8 macroporous resin (RP), and n-butanol extraction (NB-EP). We assessed the protective effects of these MLFs on H2O2-induced oxidative stress in ESMCs and analyzed the MLF components using metabolomics.Results: The results revealed that pre-treatment with MLFs dose-dependently protected ESMCs against H2O2-induced oxidative stress. The most effective concentrations were 0.8 mg/mL of CEP, 0.6 mg/mL of RP, and 0.6 mg/mL of NB-EP, significantly enhancing EMSC viability (p &lt; 0.05). These optimized MLF concentrations promoted the GSH-Px, SOD and T-AOC activities (p &lt; 0.05), while reducing MDA production (p &lt; 0.05) in H2O2-induced ESMCs. Furthermore, these MLFs enhanced the gene expression, including Nrf2 and its downstream regulatory genes (TrxR1, GPX1, GPX3, SOD1, and SOD2) (p &lt; 0.05). In terms of mitochondrial function, ESMCs pre-treated with MLFs exhibited higher basal respiration, spare respiratory capacity, maximal respiration, ATP-linked respiration compared to H2O2-induced ESMCs (p &lt; 0.05). Additionally, MLFs enhanced cellular basal glycolysis, glycolytic reserve, and maximal glycolytic capacity (p &lt; 0.05). Metabolomics analysis results revealed significant differences in mulberrin, kaempferol 3-O-glucoside [X-Mal], neohesperidin, dihydrokaempferol, and isobavachalcone among the three extraction processes (p &lt; 0.05).Discussion: Our study revealed that MLFs enhance antioxidant enzyme activity, alleviate oxidative damage in ESMCs through the activation of the Nrf2 pathway, and improve mitochondrial respiration and cell energy metabolism. Additionally, we identified five potential antioxidant flavonoid compounds, suggesting their potential incorporation into the equine diet as a strategy to alleviate exercise-induced oxidative stress.