bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient Experience of Awake Laryngoscopy Procedures
Authors: Hsu Andrea R. , Johns Heather L. , Arguelles Ivonne , O’Byrne Jamie , Ekbom Dale , Orbelo Diana , Bayan Semirra 
Published: February 2025

Objective(s): To quantify and compare pre-procedure worry versus the experience of pain, gagging, and dyspnea during in-office laryngoscopy procedures in patients who did or did not receive pre-procedure anxiolytics, and to explore patient perception of intra-procedure interventions. Methods: Patients undergoing awake laryngology procedures at a quaternary care center were enrolled. The State-Trait Anxiety Inventory (STAI) Y1 and Y2 questionnaires were administered to establish baseline levels of state anxiety and trait anxiety, respectively. Pre-procedure and post-procedure surveys assessed patient perception of select interventions. Results: 34 patients were enrolled (35.3% female, 91.2% white, mean age 60 years). Pre-procedure, 51.5% of patients reported some degree of worry about pain, 61.8% about gagging, 52.9% about dyspnea, and 55.9% about having something in their nose/throat. Post-procedure, 54.5% reported experiencing pain to some degree, 63.6% had gagging, 39.4% had dyspnea, and 78.7% were bothered by having something in their nose/throat. Patients who received a pre-procedure anxiolytic were significantly more likely to report more pain compared to those who did not. The highest rated interventions were pre-procedural education (97.0% “Very helpful”), verbal reassurance (96.9%), provider communicating steps of the procedure (96.9%), and reminders to breathe (87.5%). Conclusion: For patients undergoing awake laryngology procedures, the anticipation of gagging, pain, trouble breathing, and scope-related discomfort are worrisome factors. Of these, scope-related discomfort and gagging are the most often-reported sources of intraprocedural discomfort. The interventions patients found most helpful were based on preprocedural education and clear intraprocedural communication, which suggests that purposeful communication has a role in relieving anxiety. Level of evidence: Level 4
Quetiapine combined with escitalopram in the treatment of bipolar depression along with effects on inflammation and oxidative stress
Authors: Zhang Pingping , Huang Jinchang , Xiong Zheng , Liu Xueqin , Peng Haiying 
Published: February 2025

Objectives To assess the efficacy of escitalopram combined with quetiapine vs quetiapine alone in the treatment of depressive episodes of bipolar disorder (BPD). Methods 88 hospitalized patients with a BPD depressive episode were recruited into the study. All patients were randomized to a control group (n = 44) or the intervention group (n = 44). Members of the control group received quetiapine fumarate alone, with an initial dose 50 mg/time twice/day; the dose was increased by 50-100 mg daily until 300-600 mg/d was reached. The treatment group received quetiapine at the same doses plus escitalopram, with the initial dose of escitalopram 10 mg/d, adjusting the dose to 20 mg/d after 1 week. Both groups were treated for 8 weeks. The scores on the Hamilton Depression Scale (HAMD) and Young Mania Rating Scale (YMRS), along with levels of IL-6, IL-1β, MIF, SOD, CAT, MDA and GSH-Px, were compared between groups. Results Among those in the intervention group, 88.6% of participants experienced a 50% or greater reduction in HAMD score compared to 70.5% in the control group ( P < .05). Participants in the intervention group also experienced a significantly greater reduction in IL-6, IL-1β, MIF and MDA levels ( P < .05), and a significant increase in SOD, CAT and GSH-Px levels compared to the control group ( P < .05). Conclusion Escitalopram oxalate combined with quetiapine is more effective than quetiapine alone in the treatment of patients with bipolar depressive episodes, which can effectively improve the symptoms of depression, inhibit the body’s inflammatory response, regulate the state of oxidative stress, and does not increase the risk of mania.
Exploring Health-Seeking Behaviors Among Healthcare Workers and the General Population During the COVID-19 Pandemic: A Retrospective Quantitative Study
Authors: Castañeda-Millán Gabriela , Haritos Alexia M. , Formuli Edris , Mazur Maryna , Balakrishnar Kishana , Stephanie Long Bao-Zhu , Nowrouzi-Kia Behdin 
Published: February 2025

Background/objectives: Mental health issues are prevalent among healthcare workers, but help-seeking behavior in this groups remains under-researched. The purpose of this study was to explore predictors of and barriers to mental health help-seeking among healthcare workers in Canada, compared to workers from other sectors. Design: This quantitative study analyzed cross-sectional data from Mental Health Research Canada (MHRC) from October 2022 to January 2024. Methods: The total sample consisted of 8,191 workers from various sectors, including 419 healthcare workers. We examined prevalence of help-seeking, barriers to accessing mental health support, and predictors of help seeking using descriptive and inferential statistics. A multivariate logistic regression analysis was performed to explore the relationship between sociodemographic factors and help-seeking. Results: Healthcare workers were more likely to seek mental help support compared to workers from other sectors (OR 1.73, 95% CI: 1.35, 2.20). Healthcare workers least likely to seek mental health support were male (OR 0.58, CI 0.52, 0.66), residing in Quebec (OR 0.49, 95% CI: 0.41, 0.59), or of older age (OR 0.40, 95% CI: 0.30, 0.52). Key barriers to mental health help-seeking identified among healthcare workers included concerns about exposure to COVID-19 (33%), preference for self-management (25%), concerns about the safety of care options (18%), and lack of knowledge on how or where to seek help (13%). Conclusions: This study provides valuable insight into the barriers and predictors of mental help-seeking behavior among healthcare workers. Findings underscore the need for workplaces to foster safe, supportive, and inclusive environments to better support healthcare workers facing mental health challenges.
The Retrograde-Access Gutter Snare (RAGS) Technique: A Bailout Maneuver to Maintain Patency of the Left Subclavian Artery in Fenestrated TEVAR
Authors: Landau John H. , Dubois Luc A. , Power Adam H. 
Published: February 2025

Purpose: The purpose of this study is to describe a new bailout maneuver for use during fenestrated thoracic endovascular aneurysm repair (fTEVAR) in the event of wire wrap or wire entanglement with the proximal graft fabric. Technique: A 68-year-old-man with hypertension and chronic atrial fibrillation underwent elective thoracic endovascular aneurysm repair (TEVAR) with a left subclavian fenestration to treat a residual arch and thoracic aortic aneurysm after previous type A dissection repair. The procedure was challenging due to malrotation of the main body graft, as well as wire entanglement of the precannulated through-and-through wire on the leading edge of the main body fabric. A novel bailout maneuver is described. Through-and-through access was maintained, and a long 8F sheath was delivered through the fenestration from femoral access, and an 8.5F steerable sheath was delivered through upper extremity access. This allowed coaxial snaring of a new through-and-through wire via the gutter between the stent-graft and native aorta in the seal zone, which both reoriented the fenestration, and permitted placement of a bridging stent to the left subclavian artery. Conclusion: The retrograde-access gutter snare (RAGS) technique described above provides a streamlined approach to achieve technical success in challenging fenestrated thoracic endovascular aneurysm repair (fTEVAR) cases. Clinical Impact This technical note describes the retrograde-access gutter snare (RAGS) technique that can provide a successful bailout maneuver for fenestrated TEVAR (fTEVAR) devices. The RAGS technique offers an approach to be used with precannulated custom-made or physician-modified fTEVAR devices in which wire wrap or wire entanglement precludes access through the fenestration after deployment of the main body device. Instead of traditional attempts at de novo cannulation of the fenestration from upper extremity or femoral access, the maneuver offers an approach to maintaining through-and-through access to facilitate snaring a new wire proximal to the leading edge of the main body fabric, which can then be used to deliver a covered stent into the fenestration from either the upper extremity or femoral access. This technique offers an added benefit of potentially realigning malrotated fenestrations via tensioning of the new through-and-through wire.
Arthroscopic rotator cuff repair with bioinductive patch achieves equivalent patient-reported outcomes and retear rate at 1 year
Authors: Castle Joshua P , Kasto Johnny K , Jiang Eric X , Gaudiani Michael A , Wolterink Trevor D , Timoteo Taylor , Best Jacob , Bishai Shariff K , Kolowich Patricia A , Muh Stephanie J 
Published: February 2025

Purpose The purpose of this study was to evaluate the safety and efficacy of a bioinductive patch augmentation following arthroscopic rotator cuff repair (RCR) in terms of patient-reported outcomes, motion, and complications stratified by tear size. Methods A retrospective review of patients undergoing primary RCR with and without bioinductive bovine collagen patch augmentation for supraspinatus/infraspinatus tears from 2014 to 2022 at two centers was performed. Exclusion criteria included: age <18 years, revisions, or lack of 6-month postoperative follow-up. Patients were propensity-score matched 2:1 to patch-augmented patients based on age, sex, BMI, and tear size. Outcomes were compared between the patch and control groups after being stratified by tear size. Results A total of 125 patients patch augmented RCRs were matched to 250 controls. No significant differences in demographics or comorbidities between groups. Following stratification by tear size, VAS for partial and small/medium tears in the patch cohorts were lower ( p = 0.02) at 3 months. Functional scores were not statistically different. Patch-augmented partial and small/medium tears showed increased forward elevation ( p < 0.05) at 1-year follow-up. Retear rates were statistically similar. Conclusions Bioinductive patch augmentation demonstrates equivalent outcomes for pain and function, retear rate, but is associated with improved forward elevation up to 1-year for partial and small/medium tears. Level of evidence Level III, retrospective cohort study.
RUMS – how to compare structures of enterprise groups?
Authors: Rommelspacher Simon , Urban Adrian 
Published: February 2025

In a globalised and interconnected world, enterprise groups play an increasingly important role in the economy. At the same time, it is becoming more difficult for official statistics to map these structures correctly to be able to analyse them for the various statistical areas. Enterprise groups have complex data structures that often come from different data sources of varying quality and need to be compared at different points in time. Comparing these complex and growing entities is not trivial and has therefore rarely been done in the past across countries and sources. To fill this gap, inspired by other similarity metrics, a new similarity metric has been developed in the German statistical business register: RUMS – R ommelspacher-Urban Metric for Similarity of enterprise groups. RUMS enables the comparison of enterprise groups within and between statistical business registers. This allows the quantification of changes over time or deviations in different business registers, which can help to detect data inconsistencies to increase data quality. RUMS is defined in a way that allows flexible adjustments to the weightings of the properties that are considered in the calculation based on the specific needs of the use case.
Understanding and harnessing differences in women with ADHD: A qualitative study
Authors: Bradley Sarah , Parzych Izabela , Platts Jessica , Powell Lauren 
Published: February 2025

Women with attention deficit hyperactivity disorder (ADHD) are often misunderstood which is reinforced by deficit-focused research and gendered societal expectations that overlook neurodivergent women. Grounded in the neurodiversity approach, this work views ADHD as a cognitive difference, not deficit. Authors recognise the importance of sharing and understanding these differences as they can harness achievements, empowerment, self-advocacy skills and identity acceptance. This study invited 11 women with ADHD, to share their voices to contribute to a holistic understanding of ADHD in women with particular focus on how differences can facilitate rewarding and positive experiences. Reflexive thematic analysis identified four themes: (1) Social and communication differences can facilitate positive relationships in women with ADHD; (2) Rewarding experiences in women with ADHD are driven by differences, not deficits; (3) ADHD diagnoses in women can be ‘massive’ for identity sense-making and (4) Gendered challenges create barriers to support for women with ADHD (subtheme: Language can reinforce harmful and stigmatised views of ADHD in women). This work will facilitate improved outcomes for women with ADHD by sharing their differences, and how society can adapt to harness these differences through more gender-sensitive approaches. Lay abstract Women with attention deficit hyperactivity disorder (ADHD) experience challenges that are different to men with ADHD. There is little research around women with ADHD and the research that does exist usually focuses on their deficits, not their differences or how their differences can facilitate positive experiences. It is important that this changes, because we know this can be beneficial for women with ADHD. Benefits include improved self-esteem, reduced stigma and improved support and understanding women with ADHD. Therefore, this study interviews 11 women with ADHD about their experiences, with a focus on how differences can facilitate rewarding and positive experiences. Participants shared how their ADHD-related differences can help them to gain positive life experiences through pursuing hobbies, developing meaningful relationships and making rewarding decisions around their studies and occupations. Participants also shared challenges they had with gaining their ADHD diagnosis, and others misunderstanding their ADHD which was often reflected through use of negative language by others. By including the lived experience voices in this work, we can improve understanding of the differences experienced by women with ADHD and share how society can adapt to support women with ADHD.
Surgical lung biopsy analyses differ by race and ethnicity in interstitial lung disease
Authors: Jin Kim Eun , Dylan Douglas , Owolabi Tinuola , Lee Cathryn , Symes Emily , Husain Aliya , Strek Mary E. , Elicker Brett M. , Kukreja Jasleen , Wolters Paul J. , Jones Kirk D. , Adegunsoye Ayodeji 
Published: February 2025

RationaleEstablishing an interstitial lung disease (ILD) diagnosis may require surgical lung biopsy (SLB). While prior studies have described the epidemiology of ILDs among different races and ethnicities, the pathologic and clinical diagnoses based on SLBs associated with these demographics are unexplored.MethodsWe reviewed SLBs performed between 2000 and 2022 at the University of California San Francisco (UCSF) and the University of Chicago (UChicago) assessing histopathology using structured data collection forms. We analyzed differences in histopathologic features among White, Black, Asian, Hispanic and Native American participants.ResultsA total of 1100 patients (899 UCSF and 201 UChicago study subjects, respectively) with chronic ILD underwent SLBs. 80.6% of patients were White, 6.7% Black, 5.7% Asian, 5% Hispanic and 1.9% Native American. The mean age was 61 years, with Black participants being younger (53 years). Notable histopathologic differences include higher frequency of germinal center formation in Black subjects who also had less microscopic honeycombing, and less frequency of organizing pneumonia in Hispanic subjects. Hispanic subjects had pathologic nonspecific interstitial pneumonia (NSIP) whereas Native American subjects mostly had fibrosing IP. Hypersensitivity pneumonitis (HP) was the most common clinical diagnosis in White and Hispanic subjects, connective tissue disease (CTD)-ILD in Black subjects, and unclassifiable ILD in Native American subjects. HP and NSIP frequently require SLB.ConclusionsThis study demonstrates significant racial and ethnic differences in pathologic and clinical diagnoses among ILDs. Recognizing these differences is critical for tailoring diagnostic approaches and may impact precision medicine approaches for ILD management.
Genetic parameters and parental and early-life effects of boar semen traits
Authors: Sá Pedro , Godinho Rodrigo M. , Gòdia Marta , Sevillano Claudia A. , Harlizius Barbara , Madsen Ole , Bovenhuis Henk 
Published: February 2025

Abstract

Background
The objectives of this study were to estimate genetic parameters and studying the influence of early-life and parental factors on the semen traits of boars. The dataset included measurements on 449,966 ejaculates evaluated using a Computer-Assisted Sperm Analysis (CASA) system from 5692 artificial insemination (AI) boars. In total, we considered 16 semen traits measured on fresh semen and 6 sperm motility traits measured on semen after storage. Early-life effects included the dam’s parity, ages of the dam and sire, gestation length, litter size, litter sex ratio, number of piglets born alive, number of litter mates at weaning, rearing length, and weight gain. A repeatability model accounting for effects at collection was used to (1) estimate heritabilities and repeatabilities for semen traits and genetic and phenotypic correlations between traits, (2) test the significance of early-life effects, (3) quantify the contribution of exclusive dam and sire inheritances to the phenotypic variation, i.e., mitochondrial DNA and the Y chromosome, identified using a pedigree-based approach, and (4) quantify the contribution of maternal and paternal environment effects to the phenotypic variation of semen traits.

Results
We reported heritabilities between 0.11 and 0.27 and repeatabilities between 0.20 and 0.65 for semen traits. Semen quality traits showed a skewed distribution, and their transformation significantly reduced their repeatability estimates. Motility traits measured after storage were genetically different from motility traits measured on fresh semen. Early-life had suggestive effects on a limited number of semen traits. Mitochondrial DNA and the Y chromosome did not explain a discerning proportion of the phenotypic variance and the effect of the paternal environment was also negligible. We estimated a significant maternal environment effect predominantly on sperm motility traits, explaining between 2.3 and 4.6% of the phenotypic variance. Including maternal environmental effects in the model reduced heritability estimates for sperm motility traits and total morphological abnormalities.

Conclusions
Our findings indicate that trait transformation has a large effect on repeatability estimates of semen traits. Sperm motility traits measured on fresh semen are genetically different from sperm motility traits measured after storage. Early-life conditions can have an effect on later semen quantity and quality traits. Mitochondrial DNA and Y chromosome inheritances showed no effect on semen traits. Finally, we emphasize the importance of considering maternal effects when analysing semen traits, which results in lower heritability estimates.
Omilayers: a Python package for efficient data management to support multi-omic analysis
Authors: Kioroglou Dimitrios 
Published: February 2025

Abstract
Multi-omic integration involves the management of diverse omic datasets. Conducting an effective analysis of these datasets necessitates a data management system that meets a specific set of requirements, such as rapid storage and retrieval of data with varying numbers of features and mixed data-types, ensurance of reliable and secure database transactions, extension of stored data row and column-wise and facilitation of data distribution. SQLite and DuckDB are embedded databases that fulfil these requirements. However, they utilize the structured query language (SQL) that hinders their implementation by the uninitiated user, and complicates their use in repetitive tasks due to the necessity of writing SQL queries. This study offers Omilayers, a Python package that encapsulates these two databases and exposes a subset of their functionality that is geared towards frequent and repetitive analytical procedures. Synthetic data were used to demonstrate the use of Omilayers and compare the performance of SQLite and DuckDB.
A theory-based analysis of the implementation of online asynchronous telemedicine platforms into primary care practices using Normalisation Process Theory
Authors: Leighton Cara , Joseph-Williams Natalie , Porter Annavittoria , Edwards Adrian , Cooper Alison 
Published: February 2025

Abstract

Background
Online asynchronous telemedicine platforms are effective and have been implemented in primary care practices, but it is unclear whether implementation was successful. Implementation has not been studied on a large scale in primary care practice. Normalisation Process Theory is a sociological theory used to understand how complex practices can be embedded into routine practice. We aimed to identify and evaluate factors affecting, and make recommendations for, implementation of online asynchronous telemedicine platforms in primary care practice using Normalisation Process Theory.

Methods
A systematic search was carried out across four databases. Studies included were empirical research, published between January 2015 and November 2022, of qualitative, quantitative and mixed methods designs, focusing on implementation of online asynchronous telemedicine platforms designed for two-way secure communication between patients and healthcare professionals to give or receive medical advice in primary care. Data extraction was guided by the domains of Normalisation Process Theory: context, mechanisms, outcomes.

Results
25 reports from 21 primary studies were obtained. COVID-19 changed the context in which asynchronous platforms were implemented into primary care, due to restrictions on face-to-face contact. Coherence is supported by online platforms providing benefits for patients. Healthcare staff felt confident using platforms and better teamworking added to cognitive participation, however patient ‘misuse’ of platforms hindered this. Collective action was negatively affected by poor usability and integration of platforms into practice systems. Reflexive action through large- and small-scale studies had allowed improvements to be made, but poor response rates inhibit this. Outcomes include changed roles and responsibilities for staff and patients and high patient satisfaction. There are concerns regarding confidentiality and health inequities.

Conclusions
Increased workload, lack of integration into existing systems and poor usability affect implementation. Widespread implementation of online platforms in primary care practices can be supported by policy-makers through consistent guidelines to improve platforms’ content, functionality and compatibility with clinical systems to try to enable improvements in practice. Further research should explore patient groups or needs for which online platforms are most suitable, reasons why online platforms work better for different patients and how different patient groups can be supported to benefit from asynchronous telemedicine.