bluuebunny/crossref_metadata_2025_split huggingface dataset:
Micromonas, a small pigmented flagellate, predominates the nanoflagellate and photosynthetic picoeukaryote communities in the northern South China Sea
Authors: Guo Xin , Pang Mengwen , Zheng Xinyi , Huang Lingfeng 
Published: March 2024

AbstractA small pigmented flagellate, Micromonas, is prevalently distributed in coastal and pelagic waters. However, there have been few studies conducted to quantify their abundance in the marginal seas of the Northwest Pacific Ocean. In this study, we used fluorescent in situ hybridization with tyramide signal amplification (TSA‐FISH) to reveal the spatial distribution of Micromonas in the northern South China Sea (SCS). On average, the abundance of Micromonas was 317 cells mL−1, with the average proportions in the nanoflagellates (NF) and photosynthetic picoeukaryotes (PPE) communities being 10.94% and 15.39%, respectively. This indicates a wide distribution and dominance of this genus in the studied area. The relationships between Micromonas abundance and various environmental factors suggested that biotic correlations play more important roles than physicochemical filtering on Micromonas assemblage. This may indicate a broad environmental adaptation spectrum of this genus through its flexibility in terms of resource acquisition strategies. In summary, this study provides insight into the spatial distribution pattern of Micromonas and highlights its crucial contribution to the composition of NFs and PPE communities, which rely on biological interaction to respond to the changing environmental conditions in the northern SCS.
Screening performance of a 100‐mL water swallowing test in community‐dwelling older adults: A receiver operating characteristic analysis
Authors: Yamabe Kazumi , Nishida Takahiro , Ide Yoshihiko , Honda Sumihisa 
Published: March 2024

AbstractObjectiveThe development of a dysphagia screening test is an urgent issue in the field of frailty prevention among community‐dwelling older people. The purpose of this study was to evaluate the screening performance of a 100‐mL water swallowing test (WST).MethodsThe study employed a cross‐sectional design. Participants were 304 (65 men and 239 women, mean age = 80 years) Japanese community‐dwelling older adults aged over 65 years. We investigated swallowing disorder using the 10‐item Eating Assessment Tool (EAT‐10), and compared choking signs, swallowing time and number of swallows, and their combination in the 100‐mL WST. We calculated the sensitivity and specificity of these indices. Receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut‐off value of swallowing time and number of swallows in the 100‐mL WST based on the Youden Index among participants without choking signs.ResultsThe sensitivity and specificity of choking signs in the 100‐mL WST were 20% and 91%, respectively. The discriminating ability of swallowing time and number of swallows among participants without any choking signs was .76 and .72, respectively, in the area under the ROC curve. Diagnostic sensitivity and specificity to discriminate dysphagia from normal swallowing ability were 65% and 74% when the cut‐off was >10 s based on maximisation of the Youden Index. The 100‐mL WST performed best when the indices of choking signs and swallowing time were combined, with a sensitivity and specificity of 72% and 68%, respectively.ConclusionsThe 100‐mL WST would be an adequate screening tool when compared to the EAT‐10.
Gestational cholestyramine treatment protects adult offspring of ApoE‐deficient mice against maternal‐hypercholesterolemia‐induced atherosclerosis
Authors: Habib Marina , Croyal Mikael , Kaeffer Bertrand , Grit Isabelle , Castellano Blandine , Gourdel Mathilde , Le May Cédric , Thorin Chantal , Nazih Hassan , Ouguerram Khadija 
Published: March 2024

AbstractAimPerinatal hypercholesterolemia exacerbates the development of atherosclerotic plaques in adult offspring. Here, we aimed to study the effect of maternal treatment with cholestyramine, a lipid‐lowering drug, on atherosclerosis development in adult offspring of hypercholesterolemic ApoE‐deficient (ApoE−/−) mice.MethodsApoE−/− mice were treated with 3% cholestyramine (CTY) during gestation (G). After weaning, offspring (CTY‐G) were fed control diet until sacrificed at 25weeks of age. Atherosclerosis development in the aortic root of offspring was assessed after oil‐red‐o staining, along with some of predefined atherosclerosis regulators such as LDL and HDL by high‐performance liquid chromatography (HPLC), and bile acids (BA) and trimethylamine N‐oxide (TMAO) by liquid chromatography‐mass spectrometry (LC–MS/MS).ResultsIn pregnant dams, cholestyramine treatment resulted in significantly lower plasma total‐ and LDL‐cholesterol as well as gallbladder total BA levels. In offspring, both males and females born to treated dams displayed reduced atherosclerotic plaques areas along with less lipid deposition in the aortic root. No significant change in plasma total cholesterol or triglycerides was measured in offspring, but CTY‐G males had increased HDL‐cholesterol and decreased apolipoproteins B100 to A‐I ratio. This latter group also showed reduced gallbladder total and specifically tauro‐conjugated bile acid pools, whereas for CTY‐G females, hydrophilic plasma tauro‐conjugated BA pool was significantly higher. They also benefited from lower plasma TMAO.ConclusionPrenatal cholestyramine treatment reduces atherosclerosis development in adult offspring of ApoE−/− mice along with modulating the plaques' composition as well as some related biomarkers such as HDL‐C, bile acids and TMAO.
DUSP3 modulates IRES‐dependent translation of mRNAs through dephosphorylation of the HNRNPC protein in cells under genotoxic stimulus
Authors: Ferruzo Pault Y. M. , Boell Viktor K. , Russo Lilian C. , Oliveira Carla C. , Forti Fabio L. 
Published: March 2024

AbstractBackground InformationThe dual‐specificity phosphatase 3 (DUSP3) regulates cell cycle progression, proliferation, senescence, and DNA repair pathways under genotoxic stress. This phosphatase interacts with HNRNPC protein suggesting an involvement in the regulation of HNRNPC‐ribonucleoprotein complex stability. In this work, we investigate the impact of DUSP3 depletion on functions of HNRNPC aiming to suggest new roles for this enzyme.ResultsThe DUSP3 knockdown results in the tyrosine hyperphosphorylation state of HNRNPC increasing its RNA binding ability. HNRNPC is present in the cytoplasm where it interacts with IRES trans‐acting factors (ITAF) complex, which recruits the 40S ribosome on mRNA during protein synthesis, thus facilitating the translation of mRNAs containing IRES sequence in response to specific stimuli. In accordance with that, we found that DUSP3 is present in the 40S, monosomes and polysomes interacting with HNRNPC, just like other previously identified DUSP3 substrates/interacting partners such as PABP and NCL proteins. By downregulating DUSP3, Tyr‐phosphorylated HNRNPC preferentially binds to IRES‐containing mRNAs within ITAF complexes preferentially in synchronized or stressed cells, as evidenced by the higher levels of proteins such as c‐MYC and XIAP, but not their mRNAs such as measured by qPCR. Under DUSP3 absence, this increased phosphorylated‐HNRNPC/RNA interaction reduces HNRNPC‐p53 binding in presence of RNAs releasing p53 for specialized cellular responses. Similarly, to HNRNPC, PABP physically interacts with DUSP3 in an RNA‐dependent manner.Conclusions and SignificanceOverall, DUSP3 can modulate cellular responses to genotoxic stimuli at the translational level by maintaining the stability of HNRNPC‐ITAF complexes and regulating the intensity and specificity of RNA interactions with RRM‐domain proteins.
Lentinan inhibits cell invasion via M2 polarization of tumor‐associated macrophages and Wnt/β‐catenin signaling in non‐small cell lung cancer
Authors: Yang Yan , Cheng Yue , Mu Yanfei , Tang Xianjun , Mu Xiaosong 
Published: March 2024

AbstractNon‐small cell lung cancer (NSCLC) is an aggressive and devastating cancer due to its metastasis induced by increased invasion. Lentinan is a polysaccharide exerting antitumor roles in multiple cancers, including lung cancer. However, the influence of lentinan on cell invasion in NSCLC remains unclear. Cell invasion was detected by transwell analysis. Matrix metallopeptidase 9 (MMP9) levels were measured through immunofluorescence staining. The markers arginase‐1 (Arg‐1), CD206 and interleukin (IL)‐10 (IL‐10) of M2 macrophages, Wnt3a, and β‐catenin levels were measured by western blot or enzyme linked immunosorbent assay. Lentinan did not affect cell viability and proliferation in NSCLC cells. Lentinan suppressed cell invasion and reduced the expression and secretion of MMP9. Lentinan attenuated also M2 polarization of tumor‐associated macrophages. Moreover, lentinan mitigated the M2 macrophage conditioned medium‐mediated cell invasion and MMP9 alterations in NSCLC cells. Lentinan inhibited the activation of the Wnt/β‐catenin signaling in NSCLC cells. The activated Wnt/β‐catenin pathway reversed the suppressive effects of lentinan on cell invasion and MMP9 level in NSCLC cells. In conclusion, lentinan reduces cell invasion in NSCLC cells by inhibiting the M2 polarization of tumor‐associated macrophages and the Wnt/β‐catenin signaling.
Market intelligence gathering, asymmetric information, and the instability of money demand
Authors: Kim Seon Tae , Marchesiani Alessandro 
Published: March 2024

AbstractThe observed money demand in the U.S. had a stable negative relation with the interest rate up until the 1990s. After this period, this relation fell apart and has never been restored. We show that the central bank's ability to gather information, referred to as market intelligence (MI), matters to generate an upward‐sloping money demand curve. We calibrate the model to the U.S. data for the period from 1990 to 2019 and show that MI helps to match the money demand. We also show that it is beneficial for the society, since it mitigates the inefficiency associated with asymmetric information.
Resveratrol and tetrahydroisoquinoline effects on neutrophil sensitivity to NETosis formation in low‐risk essential thrombocythemia patients
Authors: Shahriyary Fahimeh , Amirzargar Mohammad Reza , Vafajoo Mahshid , Kooshari Ahmad , Basi Ali , Razavi Seyed Mohsen , Gharegozlou Behnaz , Shahidi Minoo 
Published: March 2024

AbstractIntroductionRecent studies scrutinize how NETosis (a unique cell death mechanism of neutrophil), impacts thrombosis patients with essential thrombocythemia (ET). This research evaluates the susceptibility of ET neutrophils to form NETs and tests two potential inhibitors, resveratrol (RSV) and tetrahydroisoquinoline (THIQ), in vitro.MethodsPlatelet‐rich plasma from low‐risk ET patients was used, along with neutrophils from both patients and controls. NET formation assays, with or without RSV and THIQ treatment after LPS stimulation, were conducted in a CO2 incubator. Evaluation included flow cytometry and fluorescence microscopy for NET formation and ELISA for TNFα, IL8, and vWF:Ag levels in patient and control plasma.ResultsNeutrophils from ET patients released more NETs than controls, confirmed by flow cytometry and fluorescence microscopy. Additionally, patients had significantly higher plasma levels of IL8 and TNFα compared to controls, while RSV was more effective than THIQ in reducing NETosis rates in these patients.ConclusionsIn ET patients, a platelet counts over 1 million indicates the need for preventive treatment against thrombotic events. Similarly, in this study, RSV and THIQ significantly reduced the rate of NETosis in ET patients with higher platelet counts, and this role was more prominent in the case of the second inhibitor (RSV).
Recognizing interspecific dominance signals? Blue tits adjust nest defence based on great tit's black bib size
Authors: Quesada Javier , Guallar Santi , Navalpotro Helena , Carrillo‐Ortiz José G. , Senar Juan Carlos 
Published: March 2024

AbstractAnimals use colours, morphological structures and behaviour to advertise their dominance status and ability to obtain resources (Resource Holding Potential, RHP) in agonistic contexts with conspecifics. Dominance relationships are also known between species, although the interactions and the information used to assess the other species' RHP remain obscure and empirical evidence of interspecific recognition of status is hard to obtain. Using behavioural inference is particularly important when a species needs to assess the potential loss of fitness in terms of reproduction or survival (e.g., risk of damage or predation) that could be inflicted by another species acting as a predator, parasite or competitor. Our study shows for the first time the existence of interspecific recognition of status signals: Blue tits Cyanistes caeruleus (subordinate species) perceive Great tits Parus major (dominant species) as threats as hole‐nesting competitors, and respond differently based on the size of the great tit's black tie stripe. Blue tits seemed to recognize the meaning of great tits' black ties because they were bolder when defending their nests against small‐tie (less dominant) great tits than when repelling attacks by large‐tie (more dominant) great tit males. Our results stress that behavioural inference can potentially be used to assess the meaning of status signals that presumably evolved in an intraspecific signalling context.
Effect of two different peritoneal dialysis modalities on wound infection in peritoneal dialysis patients: A meta‐analysis
Authors: Tang Li , Cheng Qijun , Qing Yonghong , Yu Jie , Yan Xiaoping , Liao Changbin 
Published: March 2024

AbstractPeritoneal dialysis(PD) is one of the most efficient methods in end‐stage kidney disease, and it is very important for PD to perform well. No research has been conducted to evaluate the effect of various types of PD catheters on the prognosis of post‐operative wound complications. While recent meta‐analyses are in favour of straight tubing, there is still uncertainty as to whether direct or coiled PD is beneficial. The purpose of this meta‐analysis was to compare the efficacy of direct and coiled PD catheters on the incidence of post‐operative wound infection, bleeding and peritonitis. A comprehensive search was carried out on three databases, including PubMed and Embase, and a manual search was carried out on the links in the paper. The results showed that the incidence rate of bleeding after operation and the degree of infection among the straight and coiled pipes were compared. The results showed that there were no statistically significant differences in the incidence of post‐operative wound infection among straight PD patients with coiled PD (OR, 0.79; 95% CI, 0.58–1.08 p = 0.13). No statistical significance was found in the case of PD with coiled tubing compared with that of straight PD group in wound leakage (OR, 1.17; 95% CI, 0.71–1.93 p = 0.55). No statistically significantly different rates of post‐operative peritonitis were observed for coiled tubing compared with straight ones in PD patients (OR, 1.06; 95% CI, 0.78–1.45 p = 0.7). There is no statistical significance on the rate of wound infection, wound leakage and peritonitis among coiled and straight tube in PD.
Holistic comparison of environmental barrier coating material candidates through design of a figure of merit
Authors: Ridley Mackenzie J. , Pinnisi Dominic J. , Opila Elizabeth J. 
Published: March 2024

AbstractThe first figure of merit for environmental barrier coating (EBC) materials was designed through a ranking system for material properties pertaining to established EBC failure modes in service. Seven past, present, and novel EBC candidate materials were used in the figure of merit design: SiO2, Ba0.75Sr0.25Al2Si2O8 (BSAS), HfSiO4, Yb2Si2O7, Yb2SiO5, Yb2O3, and YbPO4. Utilizing compiled data from the literature, the presented figure of merit verified Yb2Si2O7 as the state‐of‐the‐art candidate with optimal EBC properties and inferred that YbPO4 should be considered as a potentially viable EBC material candidate. The figure of merit allows for a holistic comparison of EBC candidates and informs experimental and computational search efforts for next‐generation complex EBCs. Clear knowledge gaps found through this work include CaO–MgO–Al2O3–SiO2 (CMAS)‐resistant coatings, EBC lifetimes before delamination, and oxidant diffusion rates in relevant EBC microstructures. It was shown that while some materials show promise for solving a single key failure mode for EBCs (i.e., CMAS reactivity), a community‐wide goal should be placed on materials development to achieve acceptable resistance against all major failure modes, which are interconnected. Novel compositionally complex EBC materials, in addition to layered EBC architectures, show promise for the optimization of material properties for long‐lifetime EBCs in combustion environments.
In vivo assessment of early effects of diamond‐tipped microdermabrasion through the lens of line‐field confocal optical coherence tomography
Authors: Razi Shazli , Truong Thu Minh , Khan Samavia , Sanabria Bianca , Rao Babar 
Published: March 2024

AbstractBackgroundMicrodermabrasion is a cosmetic procedure that has gained popularity for skin rejuvenation by causing repetitive intraepidermal injury to stimulate the proliferation of fibroblasts and collagen production. Various clinical studies have demonstrated microdermabrasion's effectiveness in skin rejuvenation; however, most of these studies rely on clinical observation and scoring by observers rather than histologic or microscopic analysis. In our single‐center prospective study, we used line‐field confocal optical coherence tomography (LC‐OCT), to non‐invasively visualize the early effects of one microdermabrasion treatment on the facial epidermal and dermal structure.AimUsing LC‐OCT, this study aims to elucidate the microscopic and histological effects of microdermabrasion on epidermal and dermal structures, including epidermal thickness, as well as collagen and vascular patterns.Patients/MethodsEight volunteers (Fitzpatrick skin types II–V) underwent one treatment of microdermabrasion. LC‐OCT and VISIA imaging were performed before and 10 min after microdermabrasion, and at 48‐h follow‐up. Subjective evaluations of skin texture and adverse reactions were assessed 1 week posttreatment via a telephone call.ResultsCompared to LC‐OCT images before treatment, images captured after one treatment of microdermabrasion showed a decrease in thickness and number of undulations in the stratum corneum. In the superficial dermis, enhancement in fibrillar collagen, as demonstrated by an increased prominence of crisscrossing hyper‐refractile strands, was visualized. This was consistent with subjective and objective improvement in facial rhytids calculated by VISIA skin analysis.ConclusionsTreatment monitoring with LC‐OCT demonstrated consistent histopathological changes with clinical visual improvement. Therefore, LC‐OCT, has the potential to enable long‐term histopathological monitoring of microdermabrasion and other cosmetic procedures without biopsy.
Turkish validity and reliability of the Premenstrual Change Coping Inventory
Authors: Çetin Hatice Sarı , Erbil Nülüfer 
Published: March 2024

AbstractObjectiveThis study was conducted to investigate the validity and reliability of the Turkish version of the Premenstrual Change Coping Inventory (PMS‐Cope).MethodsA total of 170 women who met the inclusion criteria were included in the methodological study. Data were collected between the dates of November 5, 2018 and May 5, 2019 with personal information form, PMS‐Cope Turkish version, and Premenstrual Syndrome Scale.ResultsThe PMS‐Cope was obtained through the translation‐back translation method and the content validity was obtained according to expert opinions. After the factor analysis, the Turkish version of the PMS‐Cope consisted of three sub‐dimensions as in the original scale. The factor loadings of the three‐dimensional scale ranged from 0.46 to 0.84, and the explained variance (60.329%) was at the desired level. As a result of structural equation modeling; ×2/SD values of the scale were found to be 4.19, GFI 0.93, AGFI 0.91, CFI 0.95, RMSEA 0.079, and SRMR 0.082, and this scale was acceptable. The Cronbach alpha coefficient of the PMS‐Cope was 0.86. It was determined that item‐total score correlations were higher than 0.30 in all items of PMS‐Cope and there was no need to remove items from the scale. When the mean scores of the lower 27% and upper 27% of the scale were compared, a statistically significant difference was found between the groups (p < 0.05). The PMS‐Cope score was 41.04 ± 8.99.ConclusionIt was determined that the Turkish version of the PMS‐Cope was a valid and reliable measurement tool.
Exploring the diagnostic accuracy and applicability of the Gugging Swallowing Screen in children with feeding and/or swallowing disorders
Authors: Georgiou Rafaella , Voniati Louiza , Papaleontiou Andri , Gryparis Alexandros , Ziavra Nafsika , Tafiadis Dionysios 
Published: March 2024

AbstractBackgroundThe Gugging Swallowing Screen (GUSS) is a bedside dysphagia screening tool that has been designed to determine the risk of aspiration in acute stroke patients. There is no evidence in the literature for the GUSS for the pediatric population. The present study aimed to determine the diagnostic accuracy of GUSS as a screening tool in the Greek language for children with dysphagia.MethodsEighty‐Greek‐Cypriot children aged 3–12 years who had dysphagia participated in this retrospective study. The translated into Greek GUSS was administered twice (pre‐ and post‐therapy) to each patient throughout 24 sessions of dysphagia therapy.Key ResultsThe GUSS showed a high internal consistency (Cronbach's α = 0.826), good test–retest reliability (rs = 0.767), convergent validity compared to the Greek Pediatric Eating Assessment tool‐10 (PEDI‐EAT‐10) total score (rs = −0.365), and inter‐rater reliability (κ = 0.863). A total cutoff points equal to 13.00 was also calculated. Aspiration was identified by the GUSS with low sensitivity and high specificity (PPV 100%, NPV 57%, LR+ NA, LR− 0.79); dysphagia/penetration was identified with high sensitivity and low specificity (PPV 33%, NPV 100%, LR+ 0.102, LR− NA).Conclusions & InferencesThe pediatric version of GUSS has been found to be a valuable tool in identifying the risk of aspiration as that of adults. It proved to be used as a good screening guide for selecting and confirming the existence of dysphagia from instrumental assessments. This is the first study of the pediatric version of GUSS, and future studies on this topic are needed.
Landscape correlates of sand racer species (Lacertidae; <em>Psammodromus</em>) segregation in their contact area along the Conquense Drove Road (Cuenca, Iberian Peninsula)
Authors: Malo Juan E. , Martín-Higuera Antonio , Mata Cristina , Azcárate Francisco M. 
Published: March 2024

The Edwards’s sand racer (Psammodromus edwarsianus) was recognised as distinct from the Spanish sand racer (P. hispanicus) a decade ago, but both their distributions and interspecific range limits are poorly defined. Results of sampling both species along 70km of the Conquense Drove Road (Central Spain) indicate a clear North/South segregation, with P. edwarsianus inhabiting the area North of Las Pedroñeras and P. hispanicus the South. The segregation corresponds with lithological and vegetation differences, hard calcareous substrates in the North and softer sandy sedimentary material in the South. The latter is associated with more intensive agricultural land-use in contrast to the persistence of copses and scrub on the calcareous terrain. The results provide new data on the regional distribution of both species. They also highlight the potential value of this species-pair as a model for study of interactions and habitat segregation in lacertids.