bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Chi Square Zona Wilayah Marketing terhadap Penjualan Produk Ekonomi Kreatif
Authors: Herinanto Dwi , Utami Bernadhita Herindri S. , Helmita Helmita , Arif Denial 
Published: April 2024

Analisis penjualan terhadap wilayah memungkinkan perusahaan untuk memahami faktor-faktor yang mempengaruhi perilaku pembelian konsumen di setiap wilayah, seperti preferensi lokal, demografi, ekonomi, dan faktor budaya. Melalui analisis penjualan pada suatu wilayah juga memungkinkan perusahaan untuk meningkatkan daya saing dan mencapai pertumbuhan bisnis yang berkelanjutan. Penelitian ini bertujuan untuk menganalisis hubungan antara produk yang ditawarkan oleh perusahaan dan wilayah pemasaran produk ekonomi kreatif dijual. Penelitian ini menggunkan uji Chi-Square untuk memberikan bukti tentang seberapa signifikan hubungan antar variabel, dan dengan menggunakan teknik ini, perusahaan dapat mengidentifikasi pola penjualan yang mungkin terjadi di berbagai wilayah dan memahami apakah ada hubungan yang signifikan antara produk tertentu dengan preferensi konsumen di wilayah tertentu. Hasil uji hipotesis, menunjukkan bahwa distribusi penjualan papan data sekolah sebagai produk ekonomi kreatif CV. Samudra Karya Sejahtera di Kabupaten Pringsewu berbeda signifikan dengan penjualan di Kabupaten Pringsewu. Ditinjau dari segi jenis sekolah (negeri dan swasta) juga tidak terdapat perbedaan signifikan antara penjualan di Kabupaten Pringsewu dan Kabupaten Tanggamus.
Welcome to the Stress and Healthy Aging Research (StAR) Lab!
Authors: Fiocco Alexandra 
Published: April 2024

<p>Housed in the Institute for Stress and Wellbeing Research and directed by Dr. Alexandra J. Fiocco, the <strong>Stress and Healthy Aging Research (StAR) Lab</strong> is dedicated to elucidating the biological and psychosocial predictors of cognitive health and emotional wellbeing in late life. In addition to predictors of cognitive health and wellbeing, the StAR research program aims to evaluate potential intervention program that may facilitate the maintenance of cognitive health and improve quality of life in later years.</p>
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The importance of cultivating mindfulness for cognitive function and psychological wellbeing in late life
Authors: Fiocco Alexandra , Mallya Sasha 
Published: April 2024

<p>The cultivation of mindfulness has received increasing attention over the past 2 decades because of its association with increased psychological well-being and reduced stress-related health disorders. Given the robust positive association between perceived stress and cognitive impairment in late life, the current study evaluated the association between trait mindfulness, psychological well-being, and cognitive function in 73 healthy community-dwelling older adults. Controlling for a priori covariates, multivariate regression analyses showed a significant association between trait mindfulness and measures of psychological well-being, including self-reported depressive symptoms, quality of life, and stress profile. Analyses further showed a significant association between trait mindfulness and executive function, namely set shifting. No association was found for declarative memory. Mediation analyses showed that the association between mindfulness and cognitive function is mediated by perceived stress. This research supports the importance of cultivating mindfulness in late life to ensure cognitive and emotional well-being.</p>
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Sodium intake and physical activity impact cognitive maintenance in older adults: The NuAge study
Authors: Fiocco Alexandra , Shatenstein Bryna , Ferland Guylaine , Payette Hélène , Belleville Sylvie , Kergoat Marie-Jeanne , Morais José A. , Greenwood Carol E. 
Published: April 2024

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<p>This study examines the association between sodium intake and its interaction with physical activity on cognitive function over 3 years in older adults residing in Québec, Canada. We analyzed a subgroup from the NuAge cohort (aged 67–84 years) with nutrient intake data, including sodium, from a food frequency questionnaire administered at baseline. Baseline physical activity was assessed using the Physical Activity Scale for the Elderly (PASE; high-low). Modified Mini Mental State Examination (3MS) was administered at baseline and annually for 3 additional years. Controlling for age, sex, education, waist circumference, diabetes, and dietary intakes, analyses showed an association between sodium intake and cognitive change over time in the low PASE group only. Specifically, in the low PASE group, elders in the low sodium intake tertile displayed better cognitive performance over time (mean decline in 3MS over years: mean [M] = −0.57, standard error [SE] = 0.002) compared with the highest (M = −1.72, SE = 0.01) and mid sodium intake (M = −2.07, SE = 0.01) groups. This finding may have significant public health implications, emphasizing the importance of addressing multiple lifestyle factors rather than a single domain effect on brain health.</p>
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Measuring perceived receipt of filial piety among Chinese middle-aged and older adults
Authors: Huang Vivian , Fiocco Alexandra 
Published: April 2024

<p>Filial piety plays an important role in the parent-child relationship in Chinese culture. To date, the majority of studies have focused on filial piety attitudes and expectations from the perspectives of the adult child. With only a few studies examining filial piety from the parent’s perspectives, there is a paucity of studies that examines the dimensionality of filial piety receipt. The objective of this study was to validate the Perceived Receipt of Filial Piety Scale (PRFPS), a 10-item questionnaire designed to measure how often Chinese parents perceive their child(ren) engage in filial pious behaviours. A total of 222 middle-aged and older adult Chinese parents (<em>M</em>age = 67.91, <em>SD</em> = 13.20) completed the PRFPS, MultidimensionalScale of Perceived Social Support (MSPSS) and the Quality of Life Scale (QOLS). A single-factor structure emerged from the developed PRFPS, which demonstrated excellent internal consistency (<em>α</em> = .95). The scale was also significantly associated with the MSPSS (<em>r</em> = .50) and QOLS (<em>r</em> = .42), supporting convergent and criterion validity. In conclusion, the PRFPS is found to be a reliable and valid measure of perceived filial piety receipt among Chinese parents. Theoretical implications and suggestions for further scale development and research is discussed.</p>
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Examining the factor structure and psychometric properties of the Chinese version of the Life Orientation Test (CLOT-R) in Older Chinese immigrants
Authors: Fiocco Alexandra , Huang Vivian , Lo Kitty Ching 
Published: April 2024

<p>The current study examined the factor structure and psychometric properties of the Chinese version of the Revised Life Orientation Test (CLOT-R) in a sample of 342 community-dwelling older Chinese immigrants in Canada (mean age = 71.99, <em>SD</em> = 5.62; 58.5% female). Confirmatory factor analysis demonstrated that the CLOT-R yields a two-factor model with one item cross-loading on two latent constructs of optimism and pessimism. Analysis further revealed poor internal consistency and convergent validity. Evidence for discriminant and convergent validity was found between optimism and perceived stress, as well as optimism and quality of life. Compared with the factor structure reported in previous Chinese-speaking samples, the modified two-factor structure found in the current group of older Chinese immigrants could be attributed to the heterogeneity of the sample and possible configural variance across culture and age. Overall, the current findings suggest that the CLOT-R may not be a reliable and valid measure to assess dispositional optimism and pessimism among older Chinese immigrants. Theoretical implications and suggestions for further scale development and research is discussed.</p>
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Can anxiety damage the brain?
Authors: Mah Linda , Szabuniewicz Claudia , Fiocco Alexandra 
Published: April 2024

<p><strong>Purpose of review </strong>Stress exacerbates mental illnesses such as depression but also appears to increase risk of dementia, suggesting a common mechanism for development of stress-induced affective and cognitive impairment. The purpose of this review is to address the question of whether anxiety ‘damages’ the brain, and to identify potential mechanisms for the link between stress and neuropsychiatric illness.</p>
<p><strong>Recent findings </strong>Anxiety disorders are associated with alterations in fear neurocircuitry such that ‘bottom-up’ processes in the amygdala which respond to threat are exaggerated, and regulation of these processes by the prefrontal cortex (PFC) and hippocampus is impaired. Chronic stress exposure similarly alters fear neurocircuitry by enhancing amygdalar functioning while causing structural degeneration in the PFC and hippocampus thereby inhibiting PFC/hippocampus control over the stress response. Pharmacological (e.g., antidepressant medications) and nonpharmacological interventions (cognitive-behavioral therapy, exercise) may reverse stress-induced damage in the brain.</p>
<p><strong>Summary </strong>Pathological anxiety and chronic stress lead to structural degeneration and impaired functioning of the hippocampus and the PFC, which may account for the increased risk of developing neuropsychiatric disorders, including depression and dementia. Longitudinal studies are needed to determine whether reversal of stress-induced brain changes by interventions such as cognitive-behavioral therapy can reduce risk of neuropsychiatric illness.</p>
Exploring biomechanical variations in ankle joint injuries among Latin dancers with different stance patterns: utilizing OpenSim musculoskeletal models
Authors: Gao Xiangli , Xu Datao , Baker Julien S. , Ee-Chon Teo , Liang Minjun , Gu Yaodong 
Published: April 2024

Background: Dancers represent the primary demographic affected by ankle joint injuries. In certain movements, some Latin dancers prefer landing on the Forefoot (FT), while others prefer landing on the Entire foot (ET). Different stance patterns can have varying impacts on dancers’ risk of ankle joint injuries. The purpose of this study is to investigate the differences in lower limb biomechanics between Forefoot (FT) dancers and Entire foot (ET) dancers.Method: A group of 21 FT dancers (mean age 23.50 (S.D. 1.12) years) was compared to a group of 21 ET dancers (mean age 23.33 (S.D. 0.94) years), performing the kicking movements of the Jive in response to the corresponding music. We import data collected from Vicon and force plates into OpenSim to establish musculoskeletal models for computing kinematics, dynamics, muscle forces, and muscle co-activation.Result: In the sagittal plane: ankle angle (0%–100%, p &lt; 0.001), In the coronal plane: ankle angle (0%–9.83%, p = 0.001) (44.34%–79.52%, p = 0.003), (88.56%–100%, p = 0.037), ankle velocity (3.73%–11.65%, p = 0.017) (94.72–100%, p = 0.031); SPM analysis revealed that FT dancers exhibited significantly smaller muscle force than ET dancers around the ankle joint during the stance phase. Furthermore, FT dancers displayed reduced co-activation compared to ET dancers around the ankle joint during the descending phase, while demonstrating higher co-activation around the knee joint than ET dancers.Conclusion: This study biomechanically demonstrates that in various stance patterns within Latin dance, a reduction in lower limb stance area leads to weakened muscle strength and reduced co-activation around the ankle joint, and results in increased ankle inversion angles and velocities, thereby heightening the risk of ankle sprains. Nevertheless, the increased co-activation around the knee joint in FT dancers may be a compensatory response for reducing the lower limb stance area in order to maintain stability.
Production of arabitol from glycerol by immobilized cells of Wickerhamomyces anomalus WC 1501
Authors: Ranieri Raffaella , Candeliere Francesco , Sola Laura , Leonardi Alan , Rossi Maddalena , Amaretti Alberto , Raimondi Stefano 
Published: April 2024

Polyalcohols such as arabitol are among the main targets of biorefineries aiming to upcycle wastes and cheap substrates. In previous works Wickerhamomyces anomalus WC 1501 emerged as an excellent arabitol producer utilizing glycerol. Arabitol production by this strain is not growth associated, therefore, in this study, pre-grown cells were entrapped in calcium alginate beads (AB) and utilized for glycerol transformation to arabitol. Flasks experiments aimed to assess the medium composition (i.e., the concentration of inorganic and organic nitrogen sources and phosphates) and to establish the appropriate carrier-to-medium proportion. In flasks, under the best conditions of ammonium limitation and the carrier:medium ratio of 1:3 (w/v), 82.7 g/L glycerol were consumed in 168 h, yielding 31.2 g/L arabitol, with a conversion of 38% and volumetric productivity of 186 mg/mL/h. The process with immobilized cells was transferred to laboratory scale bioreactors with different configurations: stirred tank (STR), packed bed (PBR), fluidized bed (FBR), and airlift (ALR) bioreactors. The STR experienced oxygen limitation due to the need to maintain low stirring to preserve AB integrity and performed worse than flasks. Limitations in diffusion and mass transfer of oxygen and/or nutrients characterized also the PBR and the FBR and were partially relieved only in ALR, where 89.4 g/L glycerol were consumed in 168 h, yielding 38.1 g/L arabitol, with a conversion of 42% and volumetric productivity of 227 mg/mL/h. When the ALR was supplied with successive pulses of concentrated glycerol to replenish the glycerol as it was being consumed, 117 g/L arabitol were generated in 500 h, consuming a total of 285 g/L glycerol, with a 41% and 234 mg/L/h. The study strongly supports the potential of W. anomalus WC 1501 for efficient glycerol-to-arabitol conversion using immobilized cells. While the yeast shows promise by remaining viable and active for extended periods, further optimization is required, especially regarding mixing and oxygenation. Improving the stability of the immobilization process is also crucial for reusing pre-grown cells in multiple cycles, reducing dead times, biomass production costs, and enhancing the economic feasibility of the process.
Prevalence of uncontrolled hypertension and contributing factors in Ethiopia: a systematic review and meta-analysis
Authors: Gobezie Mengistie Yirsaw , Hassen Minimize , Tesfaye Nuhamin Alemayehu , Solomon Tewodros , Demessie Mulat Belete , Fentie Wendie Teklehaimanot , Tadesse Getachew , Kassa Tesfaye Dessale , Berhe Fentaw Tadese 
Published: April 2024

BackgroundUncontrolled hypertension (HTN) is a major risk factor for cardiovascular and cerebrovascular disease. The prevalence of HTN in the Ethiopian adult population is almost 20%.This study aimed to determine the prevalence of uncontrolled HTN and its contributing factors among patients with HTN in Ethiopia undergoing treatment.MethodsElectronic bibliographic databases such as PubMed, Google Scholar, Hinari (Research4Life), Embase, and Scopus were searched for original records in the English language that assessed HTN control in Ethiopia and were available before 29 June 2023. The data were extracted using a format prepared in Microsoft Excel and exported to the software STATA 17.0 for analysis. The study protocol was registered at PROSPERO with the reference number CRD42023440121.ResultsA total of 26 studies with 9,046 patients with HTN were included in the systematic review and meta-analysis, of which 11 studies were used to assess factors contributing to uncontrolled blood pressure (BP) in patients in Ethiopia. The estimated prevalence of uncontrolled HTN in the population of Ethiopia is 51% [95% confidence interval (CI), 42%–60%]. The subgroup analysis, based on the assessment tools, region, and follow-up period, revealed that the prevalence of uncontrolled BP was highest following the guidelines of the American Heart Association/American College of Cardiology (AHA/ACC) (89%; 95% CI: 87%–91%) and in Addis Ababa (58%; 95% CI: 40%–76%), and the lowest proportion of uncontrolled BP was in the 3-month follow-up period (34%; 95% CI: 29%–39%). The presence of diabetes mellitus showed the highest impact (pooled odds ratio: 5.19; CI: 1.41–19.11) for uncontrolled HTN. The univariate meta-regression method confirmed that the sample size, year of publication, and subgroups were not sources of heterogeneity in the pooled estimates. Egger's regression test did not indicate the presence of publication bias.ConclusionMore than half of the hypertensive patients in Ethiopia have uncontrolled BP. Diabetes mellitus, advanced age, male sex, and the presence of comorbidities are among the factors contributing to uncontrolled HTN in Ethiopia. The concerned bodies working in this area should implement interventional strategies and recommendations that might be helpful in achieving optimal BP in hypertensive patients.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023440121, PROSPERO (CRD42023440121).
Matrix metallopeptidase 9 contributes to the beginning of plaque and is a potential biomarker for the early identification of atherosclerosis in asymptomatic patients with diabetes
Authors: Liu Bingli , Su Liping , Loo Sze Jie , Gao Yu , Khin Ester , Kong Xiaocen , Dalan Rinkoo , Su Xiaofei , Lee Kok-Onn , Ma Jianhua , Ye Lei 
Published: April 2024

AimsTo determine the roles of matrix metallopeptidase-9 (MMP9) on human coronary artery smooth muscle cells (HCASMCs) in vitro, early beginning of atherosclerosis in vivo in diabetic mice, and drug naïve patients with diabetes.MethodsActive human MMP9 (act-hMMP9) was added to HCASMCs and the expressions of MCP-1, ICAM-1, and VCAM-1 were measured. Act-hMMP9 (n=16) or placebo (n=15) was administered to diabetic KK.Cg-Ay/J (KK) mice. Carotid artery inflammation and atherosclerosis measurements were made at 2 and 10 weeks after treatment. An observational study of newly diagnosed drug naïve patients with type 2 diabetes mellitus (T2DM n=234) and healthy matched controls (n=41) was performed and patients had ultrasound of carotid arteries and some had coronary computed tomography angiogram for the assessment of atherosclerosis. Serum MMP9 was measured and its correlation with carotid artery or coronary artery plaques was determined.ResultsIn vitro, act-hMMP9 increased gene and protein expressions of MCP-1, ICAM-1, VCAM-1, and enhanced macrophage adhesion. Exogenous act-hMMP9 increased inflammation and initiated atherosclerosis in KK mice at 2 and 10 weeks: increased vessel wall thickness, lipid accumulation, and Galectin-3+ macrophage infiltration into the carotid arteries. In newly diagnosed T2DM patients, serum MMP9 correlated with carotid artery plaque size with a possible threshold cutoff point. In addition, serum MMP9 correlated with number of mixed plaques and grade of lumen stenosis in coronary arteries of patients with drug naïve T2DM.ConclusionMMP9 may contribute to the initiation of atherosclerosis and may be a potential biomarker for the early identification of atherosclerosis in patients with diabetes.Clinical trial registrationhttps://clinicaltrials.gov, identifier NCT04424706.
Influence of deflectors on indoor airflow velocity distribution under natural ventilation conditions
Authors: Wang Chaojie , Jin Meng , Cheng Haifeng 
Published: April 2024

Deflectors offer a cost-effective solution for enhancing airflow distribution. The purpose of this paper is to investigate the effect of the deflector on the indoor airflow velocity distribution under natural ventilation conditions. The results obtained from numerical simulations are validated through experimental measurements using a reduced-scale model. Subsequently, the validated reduced-scale numerical model was extended to full-size rooms. A full-size numerical simulation method is used to analyze the effect of no deflector, deflectors with different opening width-to-height ratios and deflectors with different opening shapes on the percentage of indoor velocity partitions under natural ventilation conditions. The findings reveal that the judicious installation of deflectors can enhance indoor airflow velocity distribution and increase the percentage of the indoor comfort zone. Deflectors with different opening width-to-height ratios exert distinct influences on indoor airflow velocity distribution. When the deflector opening width-to-height ratio is set at 7/6, the indoor comfort zone percentage reaches its maximum at 75.98%. Furthermore, the shape of the deflector’s opening significantly affects indoor airflow velocity distribution, and when the opening shape is a rhombus shape of 4.00 cm × 9.00 cm, the proportion of indoor velocity comfort zone is the largest, which is 75.56%. This study provides a reference for the design and practice of natural ventilation in buildings.
Evaluation of bi-directional causal association between periodontitis and benign prostatic hyperplasia: epidemiological studies and two-sample mendelian randomization analysis
Authors: Wei Haotian , Tian Guangjie , Xu Shendan , Du Yaqi , Li Minting , Wang Yonglan , Deng Jiayin , Quan Changyi 
Published: April 2024

Background: Periodontitis and benign prostatic hyperplasia (BPH) are all common chronic diseases with higher incidence in middle-aged and old men. Several studies have indicated a potential association between periodontitis and BPH, although the findings remain inconclusive. However, there is no mendelian randomization (MR) studies to assess this association.Methods: The 40 men who had received health check-ups were included in an epidemiological study. Genetic data of BPH (13118 cases and 72799 controls) and periodontitis (3046 cases and 195395 controls) from FinnGen project was used to perform two-sample MR analysis. The inverse-variance weighted (IVW) model was identified as the primary analytical method, with MR Egger, weighted median, simple mode, and weighted mode serving as additional approaches.Results: The epidemiological analysis demonstrated a lack of statistically significant differences in the prevalence of clinical BPH between severe periodontitis group and non-severe periodontitis group. Similarly, no statistically significant differences were found in the prevalence of severe periodontitis among individuals with clinical BPH compared to those without. Additionally, Among the five models utilized in MR analysis, including the IVW model, no evidence of a causal link between periodontitis and BPH was observed.Conclusion: The findings from our epidemiological investigation and MR analysis do not provide support for a causal relationship between periodontitis and BPH.