bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-midnight purple arc and patches appeared on the high latitude part of the auroral oval: Dawnside counterpart of STEVE?
Authors: Nanjo Sota , Hofstra Gabriel Arne , Shiokawa Kazuo , Shinbori Atsuki , Nozawa Satonori , Hosokawa Keisuke 
Published: April 2024

AbstractThe phenomenon known as strong thermal emission velocity enhancement (STEVE) is a purple/mauve arc-shaped atmospheric glow observed at lower latitudes of the auroral oval on the duskside. Simultaneous observations using a ground-based camera and a low-altitude satellite have shown that STEVE is accompanied by rapid westward ion flows. Such fast ion flows are termed the subauroral ion drift (SAID) or subauroral polarization stream (SAPS). Similarly, an eastward fast ion flow known as the dawnside auroral polarization stream (DAPS) is observed within the Region 1 current on the dawnside. If the optical phenomenon triggered by SAID/SAPS corresponds to STEVE, a comparable optical phenomenon should be driven by DAPS. Thus far, however, such a phenomenon has not been reported. This study discovers, for the first time, a purple-colored optical phenomenon characterized by the fast eastward ion flows, a possible signature of DAPS, occurring poleward of the bright green arc in the post-midnight sector. We present color all-sky images obtained by a ground-based commercial digital camera, along with wide-coverage optical measurements and in-situ data from low-altitude satellites. The results imply that this glow requires not only a high-speed ion flow but also its sharp latitudinal gradient at the boundary between the Region 1 and 2.
Graphical Abstract
Impact of respiratory cycle during mechanical ventilation on beat-to-beat right ventricle stroke volume estimation by pulmonary artery pulse wave analysis
Authors: Santos Arnoldo , Monge-García M. Ignacio , Borges João Batista , Retamal Jaime , Tusman Gerardo , Larsson Anders , Suarez-Sipmann Fernando 
Published: April 2024

Abstract
Background
The same principle behind pulse wave analysis can be applied on the pulmonary artery (PA) pressure waveform to estimate right ventricle stroke volume (RVSV). However, the PA pressure waveform might be influenced by the direct transmission of the intrathoracic pressure changes throughout the respiratory cycle caused by mechanical ventilation (MV), potentially impacting the reliability of PA pulse wave analysis (PAPWA). We assessed a new method that minimizes the direct effect of the MV on continuous PA pressure measurements and enhances the reliability of PAPWA in tracking beat-to-beat RVSV.

Methods
Continuous PA pressure and flow were simultaneously measured for 2–3 min in 5 pigs using a high-fidelity micro-tip catheter and a transonic flow sensor around the PA trunk, both pre and post an experimental ARDS model. RVSV was estimated by PAPWA indexes such as pulse pressure (SVPP), systolic area (SVSystAUC) and standard deviation (SVSD) beat-to-beat from both corrected and non-corrected PA signals. The reference RVSV was derived from the PA flow signal (SVref).

Results
The reliability of PAPWA in tracking RVSV on a beat-to-beat basis was enhanced after accounting for the direct impact of intrathoracic pressure changes induced by MV throughout the respiratory cycle. This was evidenced by an increase in the correlation between SVref and RVSV estimated by PAPWA under healthy conditions: rho between SVref and non-corrected SVSD – 0.111 (0.342), corrected SVSD 0.876 (0.130), non-corrected SVSystAUC 0.543 (0.141) and corrected SVSystAUC 0.923 (0.050). Following ARDS, correlations were SVref and non-corrected SVSD – 0.033 (0.262), corrected SVSD 0.839 (0.077), non-corrected SVSystAUC 0.483 (0.114) and corrected SVSystAUC 0.928 (0.026). Correction also led to reduced limits of agreement between SVref and SVSD and SVSystAUC in the two evaluated conditions.

Conclusions
In our experimental model, we confirmed that correcting for mechanical ventilation induced changes during the respiratory cycle improves the performance of PAPWA for beat-to-beat estimation of RVSV compared to uncorrected measurements. This was demonstrated by a better correlation and agreement between the actual SV and the obtained from PAPWA.
Development and flight-test verification of two-dimensional rotational low-airspeed sensor for small helicopters
Authors: Fujiwara Daigo , Tonoike Takumi 
Published: April 2024

AbstractThis paper describes the development and the verification of flight test results of a differential pressure-based, two-dimensional low-airspeed sensor designed for the navigation or disturbance detection in small helicopters. The compact and lightweight sensor is integrated with the main rotor of a small helicopter and comprises two probes at both arm ends, a differential pressure sensor, rotary encoder with one magnet and two sensors, microcomputer, a wireless data link, and battery. It measures the differential pressure between the total pressures captured by two total-pressure probes at each rotor angle, instead of using static pressure probes. Thus, the airspeed of the fuselage can be evaluated from the low speed. Flight tests were conducted employing a reference ultrasonic two-dimensional airspeed sensor for comparison. The results demonstrated that the magnitude error of the airspeed is less than 2 m/s for low-airspeed flights ($$<\sim$$

<
∼

23 m/s) when utilizing Pitot-type probes. The error in wind angle approximated 30$$^\circ$$

∘

, and the delay was less than or equal to that observed with a global navigation satellite system sensor.
Quillaja saponin mitigates methotrexate-provoked renal injury; insight into Nrf-2/Keap-1 pathway modulation with suppression of oxidative stress and inflammation
Authors: Abdel-Reheim Mustafa Ahmed , Ali Merhan E. , Gaafar Ahmed Gaafar A. , Ashour Ahmed Amine 
Published: April 2024

Abstract
Background
Methotrexate (MTX) is an antineoplastic/immunosuppressive drug, whose clinical use is impeded owing to its serious adverse effects; one of which is acute kidney injury (AKI). Most of MTX complications emerged from the provoked pro-oxidant-, pro-inflammatory- and pro-apoptotic effects. Quillaja saponaria bark saponin (QBS) is a bioactive triterpene that has been traditionally used as an antitussive, anti-inflammatory supplement, and to boost the immune system due to its potent antioxidant- and anti-inflammatory activities. However, the protective/therapeutic potential of QBS against AKI has not been previously evaluated. This study aimed to assess the modulatory effect of QBS on MTX-induced reno-toxicity.

Methods
Thirty-two male rats were divided into 4-groups. Control rats received oral saline (group-I). In group-II, rats administered QBS orally for 10-days. In group-III, rats were injected with single i.p. MTX (20 mg/kg) on day-5. Rats in group-IV received QBS and MTX. Serum BUN/creatinine levels were measured, as kidney-damage-indicating biomarkers. Renal malondialdehyde (MDA), reduced-glutathione (GSH) and nitric-oxide (NOx) were determined, as oxidative-stress indices. Renal expression of TNF-α protein and Nrf-2/Keap-1 mRNAs were evaluated as regulators of inflammation. Renal Bcl-2/cleaved caspase-3 immunoreactivities were evaluated as apoptosis indicators.

Results
Exaggerated kidney injury upon MTX treatment was evidenced histologically and biochemically. QBS attenuated MTX-mediated renal degeneration, oxidant-burden enhancement, excessive inflammation, and proapoptotic induction. Histopathological analysis further confirmed the reno-protective microenvironment rendered by QBS.

Conclusions
In conclusion, our results suggest the prophylactic and/or therapeutic effects of QBS in treating MTX-induced AKI. Such reno-protection is most-likely mediated via Nrf-2 induction that interferes with oxidant load, inflammatory pathways, and proapoptotic signaling.

Graphical Abstract
Duration of maternally derived antibodies of porcine parvovirus in growing pigs and presence of antibodies in gilts and sows vaccinated with three different parvovirus vaccines
Authors: Renzhammer René , Truyen Uwe , Buchebner Birgit , Baumgartner Gertrude , Kobialka Rea Maja , El Wahed Ahmed Abd , Koch Michaela , Ladinig Andrea , Unterweger Christine 
Published: April 2024

AbstractWhile gilts and sows are regularly vaccinated against the porcine parvovirus (PPV), little is known on the presence of antibodies in vaccinated sows nor the decline of maternally derived antibodies (MDA) in their offspring. On twelve farms serum samples were taken from 180 gilts and sows vaccinated at least twice with one of three different commercial PPV vaccines. On nine farms, additional 270 serum samples were collected from growing pigs of three different age categories. All 450 samples were examined for PPV antibodies (Abs) by ELISA and haemagglutination inhibition (HI) assay. In total, 65% of all gilts vaccinated twice with either vaccine 1 or vaccine 3 were seronegative by HI assay. In each farm, there were at least three animals with high Ab titres (≥ 1:1280) indicating the presence of PPV in all twelve study farms. However, PPV DNA could not be detected in collected faecal samples. While low to moderately high Ab titres (1:10–1:640) were measured in 98% of twelve-weeks-old pigs, ELISA was only positive in 30% of the same pigs. Though, the statement on the duration of MDA may depend on the applied test, we could confirm an exponential decay of MDA. In addition, we could demonstrate that applied serological tools are insufficient for the confirmation of successful vaccination.
Efficacy of Ban-Qin-Fei-Re-Qing oral liquid on avian infectious bronchitis
Authors: Ma Danyang , Gao Xueyan , Wang Pingping , Yang Fenfang , Huang Tingting , Fan Yimeng , Xu Xiaoqin , Xie Huisheng , Hao Zhihui 
Published: April 2024

AbstractInfectious bronchitis virus (IBV) can cause respiratory infections in animals that often lead to heavy losses for breeding industry. Ban-Qin-Fei-Re-Qing oral liquid (BQ), a Chinese herbal compound, has been used to treat infectious bronchitis (IB). This research aimed to assess the antiviral effect of BQ against IBV and elucidate the underlying mechanisms through bioinformatics analysis. The experiments designed in this study investigated how BQ inhibits IBV propagation in chicken embryos and enhances protective effects on chicken embryos. The findings indicated that, in comparison to the model group (untreated), the BQ-treated groups exhibited a significant protective effect on IBV-infected chicken embryos. Moreover, the groups administered medium or high doses of BQ demonstrated a superior protective effect compared to the group treated with a lower dose. In addition, even at a low dose (2.5 mL/L), BQ successfully treated IB in chickens. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed that the differentially expressed genes were enriched in antiviral pathways, such as the JAK/STAT and type I interferon signaling pathways. In conclusion, the current study demonstrated that BQ has antiviral activity and plays an antiviral role through the combined action of multiple antiviral pathways. These findings could lead to future research on identifying drugs to prevent and treat IB.
Analysis of thicknesses of blood collection needle by scanning electron microscopy reveals wide heterogeneity
Authors: Lippi Giuseppe , Harbatsevich Maksim , Zayats Vera 
Published: April 2024

Abstract

Objectives
The preanalytical phase in clinical laboratory diagnostics is currently receiving more and more attention. This term describes one part of actions and aspects of the “brain-to-brain cycle” of the medical laboratory diagnostic procedure that take place before the analytical phase. However, the preanalytical activities, the handling of unsuitable samples and the reporting procedures are neither fully standardized nor harmonized worldwide. The influence of the properties of the blood collection needle must be acknowledged. In this work, we focused on the investigation of the internal structure and size of standardized 21G blood collection needles.

Methods
All parameters were measured with a scanning electron microscope using a Jeol model JSM-6000PLUS. Our.

Results
The obtained data shows that the internal surfaces of the needles vary greatly from manufacturer to manufacturer (by around 35 %), and this may play an important role in influencing blood flow and even the risk of blood cell injury (especially hemolysis) during blood drawing.

Conclusions
The differential actual needle diameters can vary greatly between needle manufactures and this variety may have a significant impact on laboratory values and may also lead to specimen rejection.
Experimental and theoretical analysis of single-jet column and concrete column using double-jet grouting technique applied at Al-Rashdia site
Authors: Al-Khadaar Rana M. , Ahmed Mahmood D. 
Published: April 2024

Abstract
Progress in jet grouting technology has been focused on the cutting-edge observer of jets, which aims to generate large columns of jet grouting and increase the activity of construction sites. Since jet grouting techniques vary from conventional grouting methods to modern techniques, they can be used in a variety of soil types and their application areas are expanding quickly. So, grouting methods have become very popular methods for subsoil strengthening. This article includes finding the physical and mechanical properties of the soil of the AL-Rashdia site, using a single-jet grouting machine and a steel model to test concrete piles and jet piles, and a double-jet grouting machine to compare the results obtained from laboratory model of one-dimensional jet grouting column pile with those of a one-dimensional concrete pile. The comparison showed that the settlement of the jet pile was smaller than that of the concrete pile and the bearing load was higher with jet columns giving a high bearing capacity comparable with the concrete pile. Shen’s method is more adequate to find the ultimate bearing load and the settlement for this load. Also, the ultimate pile ratio was 115.63% for the jet column, and the ultimate pile ratio for the concrete column was 123.49%. The compressive strength of the core sample of jet columns was large which improved the bearing capacity of the foundation.
The comparative study of Ti-bearing oxides introduced by different methods
Authors: Zhao Yu-hao , Cheng Xiang , Li Hui , Kong Hui 
Published: April 2024

Abstract
The Ti-bearing oxides are introduced into HRB400 steel melt through external addition method (EAM, TiO2) and internal precipitation method (IPM, Ti alloy) using a vacuum induction furnace, respectively. For each experiment, the instantaneous evolution of oxide properties was investigated through the analysis of intermediate samples. For the EAM method, it was found that the titanium content gradually increased with increase in the treatment time. Similar increasing trend is also observed for Ti-bearing oxide properties, such as the number density and normalized titanium content. These phenomena are totally different from those in the IPM intermediate samples, in which both Ti content and Ti-bearing oxide features show rapid increase, reaching saturation at 1 min after the addition of Ti alloy, and remain relatively stable thereafter. This comparison hints that after TiO2 addition, they first dissolve in molten steel, then decompose, and finally again form Ti-bearing oxides. Furthermore, in the case of similar titanium content, EAM intermediate samples exhibit higher Ti-bearing oxide number density and higher normalized titanium content compared to IPM samples. After heat treatment, the intragranular ferrite nucleation was observed in cast sample of EAM, which was induced by the introduced Ti-bearing oxides.
Transitivity and agency in Richard Jefferies’s rural essays: an ecostylistic analysis
Authors: Federici Annalisa 
Published: April 2024

Abstract
This essay aims to provide an ecostylistic analysis of transitivity and agency in selected extracts from Richard Jefferies’s late nineteenth-century rural essays, which were collected in his so-called country books. Jefferies’s portrayal of the interconnection between humans and the natural environment has been variously described as “pantheistic”, a “pantheist revery”, or an “ecstatic communion”. The present study proposes to validate these claims by showing that Jefferies’s essays utilise patterns of transitivity to depict manifold relationships between human and non-human agents in placid landscape descriptions. These can be regarded as positive discourse praising the rural environment and humans’ entanglement with other animal and vegetable organisms. An in-depth scrutiny of the linguistic patterns of Jefferies’s texts, corroborated by the theoretical and methodological framework of (eco)stylistics and related disciplines (i.e. Systemic Functional Grammar), offers useful insights into the author’s ecosophy and holistic understanding of the human and non-human world. By conceptualising the various constitutive elements of the physical environment as active/agentive participants in particular types of processes, Jefferies gives special prominence to ecocentric, rather than anthropocentric positions.
Association between proinflammatory cytokines and arterial stiffness in type 1 diabetic adolescents
Authors: Reis Mónica , Teixeira Ana , Cardoso Juliana , Borges Teresa , Caldas Afonso Alberto , Correia-Costa Liane 
Published: April 2024

Abstract

Objectives
Type 1 diabetes mellitus is considered a state of chronic low-grade inflammation and activation of the innate immune system, which is regulated by several proinflammatory cytokines and other acute-phase reactants. Arterial stiffness, a dynamic property of the vessels evaluated by the determination of pulse wave velocity (PWV), is increased in diabetic patients and is associated with microvascular and macrovascular complications of diabetes and higher cardiovascular risk. In the present study, we aimed to compare the proinflammatory state and arterial stiffness in diabetic and non-diabetic adolescents, and to characterize the association between these two parameters.

Methods
Twenty-three type 1 diabetic patients, aged 12–16 years, followed at a tertiary center, and 23 adolescents nonoverweighted healthy controls, from a Portuguese birth-cohort, were included in the present analysis. Anthropometry, blood pressure, glycemic control data, and lipid parameters were collected. Arterial stiffness was evaluated by carotid–femoral pulse wave velocity. Proinflammatory cytokines’ concentrations (TNF-α, IL-1β, IL-6, IL-10, IFN-γ, and GM-CSF) were quantified by multiplex immunoassays using a Luminex 200 analyzer.

Results
There were no statistically significant differences between the proinflammatory cytokines’ concentrations in the two groups. PWV [6.63 (6.23–7.07) vs. 6.07 (5.15–6.65) m/s, p=0.015] was significantly higher in the diabetic group. PWV was negatively correlated with GM-CSF (ρ=−0.437, p=0.037) in the diabetic group. A linear association was found between diabetes duration and PWV (with PWV increasing by 0.094 m/s (95 % confidence interval, 0.019 to 0.169) per month of disease duration). In the diabetic group, HbA1c was negatively correlated with IL-10 (ρ=−0.473, p=0.026). Negative correlations were also found between IL-10 and total, HDL, and LDL cholesterol only in the diabetic group.

Conclusions
Diabetic adolescent patients present higher PWV, when compared to their healthy counterparts, even though we could not find differences in the levels of several proinflammatory cytokines between the two groups. The negative correlation found between IL-10 and HbA1c might translate a protective counterbalance effect of this anti-inflammatory cytokine, which might also explain the negative correlations found with blood lipids. Further studies are needed to better clarify the association between arterial stiffness and the proinflammatory milieu of diabetes.
Seasonal breeding in three sympatric rodent species in semi-arid Tigray, northern Ethiopia
Authors: Welegerima Kiros , Makundi Rhodes H. , Vanden Broecke Bram , Mbije Nsajigwa E. , Meheretu Yonas 
Published: April 2024

Abstract
We investigated the breeding activity of three sympatric rodent species: Stenocephalemys albipes, Mastomys awashensis, and Acomys cahirinus, in the semi-arid region of Tigray in northern Ethiopia, using mark-recapture data, to determine the influence of rainfall on their breeding patterns within exclosure (i.e., protected area from livestock grazing). Breeding activities of S. albipes and M. awashensis commenced during the wet season, continued into the early dry season, and ceased during the subsequent dry season. The proportion of breeding females reached its peak during the wet season, gradually declining until the dry season. In contrast, A. cahirinus exhibited a different breeding strategy, with year-round breeding, including during the dry season, a period characterized by limited resources. A significant difference in the proportion of breeding females among the three species was observed across seasons. Furthermore, all species shared a common trend of heightened breeding activity, particularly at the conclusion of the wet season and the onset of the early dry season. These findings enhance our understanding of the interplay between rainfall and seasonal breeding within exclosures, while other variables remain constant. Moreover, the region’s future plans for managing rodents and the establishment of exclosures must take this information into account.
Roberto Mangabeiros Ungerio įgalintos demokratijos teorija: ar liberalios demokratijos antinomijos gali būti išspręstos?
Authors: Kaminskas Dominykas 
Published: April 2024

The purpose of this article is to analyze Roberto Mangabeira Unger’s theory of empowered democracy and to evaluate it with regard to antinomies of liberal thought as formulated by the author himself. This article discusses the main presumptions of Unger’s political philosophy and his conceptualization of politics. The theory of empowered democracy is analyzed as an attempt to overcome the antinomy of the universal and the particular, which permeates the liberal worldview. Unger criticizes liberal thought and its central components – liberal psychology and ethics. This critique of liberalism serves as a basis for the philosopher’s vision of politics, at the centre of which is an emancipated and autonomous individual. “Negative capability”, which is the power of individuals to review and rebuild their social contexts, helps them create a political order, which aims to create a “bigger life for all”. To empower individuals, Unger offers a wide-ranging set of changes – starting with more plasticity in political institutions and ending with political protection of the individual ensured by “immunity rights” and prevention of “false necessities”. This article aims to show that Unger’s theory ultimately fails in this goal due to contradictions between the theory of empowered democracy and the author’s own conception of politics as well as due to questionable sustainability of such solution.