bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy and safety of exercise regimens to mitigate chemotherapy cardiotoxicity: a systematic review and meta-analysis of randomized controlled trials
Authors: Amin Ahmed Mazen , Khlidj Yehya , Abuelazm Mohamed , Ibrahim Ahmed A. , Tanashat Mohammad , Imran Muhammad , Nazir Abubakar , Shaikhkhalil Hosam , Abdelazeem Basel 
Published: February 2024

Abstract
Background
Cardiotoxicity is one of the most common adverse events of the chemotherapy. Physical exercise was shown to be cardioprotective. We aim to estimate the efficacy and safety of exercise in cancer patients receiving cardiotoxic chemotherapy.

Methods
We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs), which were retrieved by systematically searching PubMed, Web of Science, SCOPUS, Cochrane, Clinical Trials.gov, and MedRxiv through July 17th, 2023. We used RevMan V. 5.4 to pool dichotomous data using risk ratio (RR) and continuous data using mean difference (MD), with a 95% confidence interval (CI). PROSPERO ID: CRD42023460902.

Results
We included thirteen RCTs with a total of 952 patients. Exercise significantly increased VO2 peak (MD: 1.95 with 95% CI [0.59, 3.32], P = 0.005). However, there was no significant effect regarding left ventricular ejection fraction, global longitudinal strain, cardiac output, stroke volume, left ventricular end-diastolic volume, left ventricular end-systolic volume, E/A ratio, resting heart rate, peak heart rate, resting systolic blood pressure, and resting diastolic blood pressure. Also, there was no significant difference regarding any adverse events (AEs) (RR: 4.44 with 95% CI [0.47, 41.56], P = 0.19), AEs leading to withdrawal (RR: 2.87 with 95% CI [0.79, 10.43], P = 0.11), serious AEs (RR: 3.00 with 95% CI [0.14, 65.90], P = 0.49), or all-cause mortality (RR: 0.25 with 95% CI [0.03, 2.22], P = 0.21).

Conclusion
Exercise is associated with increased VO2 peak in cancer patients receiving cardiotoxic chemotherapy. However, there was no significant difference between exercise and usual care regarding the echocardiographic and safety outcomes.
Improved electrical coupling integrated energy system based on particle swarm optimization
Authors: Wang Lei 
Published: February 2024

AbstractThe rational utilization of energy is an important issue for sustainable development. Electrically coupled integrated energy systems can enhance energy utilization efficiency and reduce energy costs. However, traditional integrated energy system optimization has problems with local optima and slow convergence speed, which cannot fully utilize energy resources. Therefore, this study proposes an improved electrical coupling integrated energy system on the ground of particle swarm optimization algorithm. In response to the problems of local optima and slow convergence speed in traditional optimization algorithms, particle swarm optimization algorithm is introduced for system optimization. By combining PSO with simulated annealing algorithm, the possibility of PSO in global optimization is reduced. The local search ability of PSO and the global search ability of simulated annealing algorithm are used to find the optimal solution. The particle swarm optimization algorithm is used for preliminary search. When the particle falls into the local optimal, the simulated annealing algorithm is introduced for global search, and the particle is guided to jump out of the local optimal and continue searching. The experiment demonstrates that the improved algorithm has certain advantages in solving test functions. The variance, mean, and optimal values are 0.00125, 0.13874, and 0.105531, respectively, which are all better than the particle swarm optimization algorithm. The simulated annealing algorithm improved the particle swarm optimization algorithm with a high accuracy index, which eventually stabilized above 0.9, and the recall index also remained above 0.8. After 100 iterations, it had already fallen into a local optimal solution. By applying the improved hybrid optimization algorithm to the electrically-coupled integrated energy system, the distribution of various energy sources can be managed and optimized more effectively, and the overall performance of the system can be improved. Especially when dealing with complex energy scheduling and distribution problems, the algorithm can provide more stable, efficient and reliable solutions. This study can achieve efficient operation and optimized scheduling of integrated energy systems, reduce energy consumption and environmental pollution, and reduce energy costs. And it can improve the reliability and stability of energy supply, which has important application value and research significance.
Can ultrasound shear wave elastography differentiate between malignant and benign pleural effusions?
Authors: Taymour Takeya Ahmed , Mohamed Libya Saleh Wasel , El Hinnawy Yasmine Hamdy , El-Mageed Mohammed Raafat Abd 
Published: February 2024

Abstract
Background
Malignant pleural effusion is a common and unfortunately serious condition that is related to life poor quality and mortality. The majority of malignant pleural effusion is metastatic in nature, with the most encountered primary neoplasm in men is the lung cancer while in women is the breast cancer. Ultrasound elastography, with its ability of evaluating tissue stiffness, has been used to differentiate malignant from benign diseases. Shear wave elastography (SWE) has been explored in several organs, like the liver, breast, thyroid, lymph nodes and prostate, with the pleura can now be included among the growing list of SWE applications. Shear wave elastography may help in the differentiation of transudative and exudative types of pleural effusions.

Results
In this study, a total of 36 patients were included, 50% revealed malignant pleural effusions (10/18 mesothelioma) and (8/18 metastatic), while the 50% revealed benign pleural effusions (9/18 transudates) and (9/18 exudates). By using sensitivity analysis test of the SWE values with V1 represents the minimum value, V2 the maximum value to calculate the cutoff values that will be used in our final diagnosis in order to differentiate benign and malignant cases. V1 shear wave elastography can significantly predict the malignant pleural effusion with p value 0.001 using a cutoff 48 kPa with calculated sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were as follows 94.4%, 88.9%, 89.5% & 94.4% respectively with diagnostic accuracy of 92%. SWE maximum value (V2) can significantly predict the malignant pleural effusion with p value 0.001 using a cutoff 54.2 kPa, with calculated sensitivity, specificity, PPV and NPV were as follows 94.4%, 94.4%, 94.4% and 94.4% respectively with diagnostic accuracy 94.4%. So, through comparing both cutoff values, we concluded that the cutoff value 2 is better with greater specificity, PPV and NPV in relation to the final diagnosis.

Conclusions
Combination of both conventional transthoracic ultrasound and SWE quantitative and qualitative abilities in assessment of both pleural and parenchymal lesions can result in high diagnostic accuracy. Shear wave elastography alone is a sensitive, specific, useful, cost-effective, widely available and noninvasive tool for assessment of tissue stiffness and in matters of high sensitivity. 54.2 kPa can be used as the cutoff value to distinguish MPE from benign pleural disease.
Sensor placement algorithm for faults detection in electrical secondary distribution network using dynamic programming method: focusing on dynamic change and expansion of the network configurations
Authors: Mnyanghwalo Daudi Charles , Kawambwa Shamte Juma 
Published: February 2024

AbstractModern power grids are developing toward smartness through the use of sensors in gathering data for situation awareness, visibility, and fault detection. In most developing countries, fault detection in the electrical secondary distribution network (SDN) is very challenging due to the lack of automated systems for network monitoring. Systems for monitoring faults require sensor placement on each node, which is not economically feasible. Hence, optimal placement algorithms are required to ensure that the network is observable with few sensors possible. The existing sensor placement methods based on mathematical and heuristic approaches are efficient for transmission and primary distribution networks which are mostly static in size and layout. Such methods may not be efficient in SDN which is dynamic in size and have a relatively large number of nodes. This study proposes an enhanced dynamic programming method for sensor placement to enhance fault detection in SDN. The proposed algorithm employs the depth search concepts and the parent–children relationship between nodes to determine sensor types and locations considering the optimal cost. The proposed algorithm was compared with other methods including particle swarm optimization, genetic algorithm, and chaotic crow search algorithm using different network configurations. The results revealed that the proposed algorithm suggested the minimum number of sensors and shortest convergence time of 1.27 min. The results also revealed that, on network expansion, maintaining the location of the existing sensors is more cost-effective by 20% than reallocating the existing sensors. Furthermore, the results revealed that an average of 30% of nodes, need sensors to observe the entire network, hence cost optimization.
Revealing complexity: segmentation of hippocampal subfields in adolescents with major depressive disorder reveals specific links to cognitive dysfunctions
Authors: Zhang Yixin , Liu Xuan , Yang Ying , Zhang Yihao , He Qiang , Xu Feiyu , Jin Xinjuan , Gao Junqi , Yao Yuan , Yu Dexin , Hommel Bernhard , Zhu Xingxing , Wang Kangcheng , Zhang Wenxin 
Published: February 2024

Abstract

Background
Hippocampal disruptions represent potential neuropathological biomarkers in depressed adolescents with cognitive dysfunctions. Given heterogeneous outcomes of whole-hippocampus analyses, we investigated subregional abnormalities in depressed adolescents and their associations with symptom severity and cognitive dysfunctions.

Methods
MethodsSeventy-nine first-episode depressive patients (ag = 15.54 ± 1.83) and 71 healthy controls (age = 16.18 ± 2.85) were included. All participants underwent T1 and T2 imaging, completed depressive severity assessments, and performed cognitive assessments on memory, emotional recognition, cognitive control, and attention. Freesurfer was used to segment each hippocampus into 12 subfields. Multivariable analyses of variance were performed to identify overall and disease severity-related abnormalities in patients. LASSO regression was also conducted to explore the associations between hippocampal subfields and patients’ cognitive abilities.

Results
Depressed adolescents showed decreases in dentate gyrus, CA1, CA2/3, CA4, fimbria, tail, and molecular layer. Analyses of overall symptom severity, duration, self-harm behavior, and suicidality suggested that severity-related decreases mainly manifested in CA regions and involved surrounding subfields with disease severity increases. LASSO regression indicated that hippocampal subfield abnormalities had the strongest associations with memory impairments, with CA regions and dentate gyrus showing the highest weights.

Conclusions
Hippocampal abnormalities are widespread in depressed adolescents and such abnormalities may spread from CA regions to surrounding areas as the disease progresses. Abnormalities in CA regions and dentate gyrus among these subfields primarily link with memory impairments in patients. These results demonstrate that hippocampal subsections may serve as useful biomarkers of depression progression in adolescents, offering new directions for early clinical intervention.
Exploring Demographic Differences and Outcomes in Early-Onset Colorectal Cancer
Authors: Siromoni Beas , Groman Adrienne , Parmar Kanak , Mukherjee Sarbajit , Vadehra Deepak 
Published: February 2024

PURPOSE Early-onset colorectal cancer (EOCRC), defined as CRC diagnosed before age 50 years, has increased significantly worldwide. The majority of EOCRCs do not appear to be driven by genetic factors and may be influenced by environmental factors. We hypothesized that sociodemographic disparities exist in EOCRC. The purpose was of the study was to examine the geographic disparities in patients with EOCRC. METHODS We retrospectively examined the SEER database from 1976 to 2016 to examine the geographic disparities in EOCRC. A total of 73,378 patients with EOCRC were included in the analysis. We performed univariate and multivariable analyses to evaluate overall survival (OS) and disease-specific survival (DSS). Sociodemographic factors, including the location of residence (metropolitan areas [MA] or rural areas [RA]), sex, race, insurance status, and marital status, were included in the statistical analysis. RESULTS The incidence and mortality rates were consistently higher in RA versus MA during the study period. Multivariable analysis showed that patients living in RA had worse OS (hazard ratio [HR], 1.14; P < .01) and DSS (HR, 1.15; P < .001) compared with those living in MA. Similarly, non-Hispanic Black ethnicity and uninsured patients had significantly worse survival when compared with non-Hispanic White and insured patients, respectively. Married status showed better survival outcomes. CONCLUSION Patients with EOCRC living in RA have worse outcomes. Understanding the mechanisms behind such socioeconomic disparities is important so that future studies can reduce these disparities.
Concordance in Oncogenic Alterations Between the Primary Tumor and Advanced Disease: Insights Into the Heterogeneity of Intrahepatic Cholangiocarcinoma
Authors: McIntyre Sarah M. , Preston William A. , Walch Henry , Sharib Jeremy , Kundra Ritika , Sigel Carlie , Lidsky Michael E. , Allen Peter J. , Morse Michael A. , Chen Wei , Cercek Andrea , Harding James J. , Abou-Alfa Ghassan K. , O'Reilly Eileen M. , Park Wungki , Balachandran Vinod P. , Drebin Jeffrey , Soares Kevin C. , Wei Alice , Kingham T. Peter , D'Angelica Michael I. , Iacobuzio-Donahue Christine , Jarnagin William R. 
Published: February 2024

PURPOSE Intrahepatic cholangiocarcinoma (ICCA) is characterized by significant phenotypic and clinical heterogeneities and poor response to systemic therapy, potentially related to underlying heterogeneity in oncogenic alterations. We aimed to characterize the genomic heterogeneity between primary tumors and advanced disease in patients with ICCA. METHODS Biopsy-proven CCA specimens (primary tumor and paired advanced disease [metastatic disease, progressive disease on systemic therapy, or postoperative recurrence]) from two institutions were subjected to targeted next-generation sequencing. Overall concordance (oncogenic driver mutations, copy number alterations, and fusion events) and mutational concordance (only oncogenic mutations) were compared across paired samples. A subgroup analysis was performed on the basis of exposure to systemic therapy. Patients with extrahepatic CCA (ECCA) were included as a comparison group. RESULTS Sample pairs from 65 patients with ICCA (n = 54) and ECCA (n = 11) were analyzed. The median time between sample collection was 19.6 months (range, 2.7-122.9). For the entire cohort, the overall oncogenic concordance was 49% and the mutational concordance was 62% between primary and advanced disease samples. Subgroup analyses of ICCA and ECCA revealed overall/mutational concordance rates of 47%/58% and 60%/84%, respectively. Oncogenic concordance was similarly low for pairs exposed to systemic therapy between sample collections (n = 50, 53% overall, 68% mutational). In patients treated with targeted therapy for IDH1/2 alterations (n = 6) or FGFR2 fusions (n = 3), there was 100% concordance between the primary and advanced disease specimens. In two patients, FGFR2 (n = 1) and IDH1 (n = 1) alterations were detected de novo in the advanced disease specimens. CONCLUSION The results reflect a high degree of heterogeneity in ICCA and argue for reassessment of the dominant driver mutations with change in disease status.
Innovation Subjects Impacting Business Model Changes in Chinese Wooden Furniture Manufacturers: An Empirical Study
Authors: Lin Meng , Shan Liyan , Cao Yukun , Li Weidong 
Published: February 2024

Abstract
In the era of a digital economy, business model innovation takes on a critical significance to the transformation of conventional manufacturing enterprises. Factors for the innovation originate from both inside and outside the manufacturing enterprises. Previous studies focused on external factors, and few on the main factors of innovation. With Chinese wooden furniture manufacturing enterprises as an example, the paper focuses on the effect of innovation subject factors on the formation and practice of business model innovation planning. It was found that employees of all ages and levels have different ideas about business model innovation practice, and learning and absorptive abilities of employees, entrepreneurship, and factors at all dimensions of enterprise culture at the organizational level play an active promoting role at different stages of business model innovation, among which enterprise culture has a regulatory effect. This study enriches the research field about the effect of innovation subjects on business model innovation behaviors, and provides reference for wooden furniture manufacturing enterprises and even conventional manufacturing enterprises to facilitate the realization of business model innovation.
Experimental Study on Compression Moulding of Carya cathayensis Husks at Room Temperature
Authors: Xu Xiaofeng , Yu Guosheng , Zhang Wei , Wang Jue , Yao Wenbin 
Published: February 2024

Abstract
Using crushed hickory husks as raw materials, a single factor test was carried out on a hydraulic-plunger forming machine with different moisture contents and length–diameter ratios (LDRs) of forming mould in order to obtain biomass moulding fuel (BMF) briquettes. The moulding pressure in the forming mould was measured by the sensor, and the microstructures of the BMF briquettes were observed via stereomicroscope. Results showed that hickory husks could be compressed and formed into BMF briquettes at room temperature. When the moisture content of the raw materials was 14 percent and LDR of the forming mould was 4.5, the quality of BMF was best, and relaxation density of the BMF briquette was 0.98 g/cm3. When the moisture content stayed same, the forming pressure increased correspondingly with the increase of the LDR of the forming mould. When the LDR of the forming mould stayed the same, the moulding pressure increased first and then decreased with increase of moisture content. This study is of great significance because it demonstrates improvement in the utilization range of hickory husks, with the potential for reducing environmental pollution and increasing farmers’ income.
Five-year survival of triple-negative breast cancer and the associated clinicopathological factors: a study in an Indonesian tertiary hospital
Authors: Yulian Erwin Danil , Fachriza Ihza 
Published: February 2024

BACKGROUND Triple-negative breast cancer (TNBC) has a worse rate of recurrence, survival, and overall survival. This study aimed to find the survival of TNBC and its clinicopathological factors at Cipto Mangunkusumo Hospital.
METHODS This study used survival analysis based on clinicopathology in 112 TNBC cases at Cipto Mangunkusumo Hospital, Jakarta, Indonesia, diagnosed from 2009 to 2019. Kaplan–Meier and log-rank tests were used for the analysis. Bivariate and multivariate analyses using Cox regression were performed to obtain the hazard ratios (HRs).
RESULTS Most patients were diagnosed at the locally advanced stage (40.2%) compared to the early (33.0%) and metastatic stages (17.9%). The 5-year survival of TNBC was 81.2% with an HR value of 1.372 (p = 0.239) compared to luminal A. Bivariate analyses showed that the older age group with an HR of 6.845 (p = 0.013; CI 1.500–31.243), larger tumor size and extension (T) with an HR of 11.826 (p = 0.001; CI 2.707–51.653), broader regional lymph node involvement (N) with an HR of 8.929 (p = 0.019; CI 1.434–55.587), farther distant metastases (M) with an HR of 3.016 (p = 0.015; CI 1.242–7.322), more lymphovascular invasion with HR of 3.006 (p = 0.018; CI 1.209–7.477), and not operated-on cases with an HR of 9.165 (p<0.001; CI 3.303–25.434) significantly shortened the survival of TNBC. Multivariate analysis found that the only factor worsening the survival was not having surgery, with an HR of 6.175 (p<0.001; CI 1.518–34.288).
CONCLUSIONS The 5-year survival rate of TNBC patients was 81.2%. Not having surgery was a clinicopathological factor that worsened survival outcomes in TNBC.
Female adolescent sexual reproductive health service utilization concerns: A qualitative enquiry in the Tema metropolis of Ghana
Authors: Agbenu Innes , Kyei Josephine , Naab Florence 
Published: February 2024

Background
Evidence globally indicates that female adolescents face numerous sexual and reproductive health (SRH) risks. Utilization of sexual reproductive health services among adolescents is of global health importance and plays a crucial role in adolescent sexual reproductive health outcomes and their quality of life.

Aim
The current study explored sexual reproductive health service utilization concerns among female adolescents in the Tema Metropolis in Southern Ghana using the Anderson and Newman Behavioural model of Health Service Utilization as a guiding framework.

Methods
The study utilized a qualitative exploratory descriptive design. Purposive sampling was used to recruit female adolescents. In-depth face-to-face interviews were conducted using a semi-structured interview guide. In all, 12 interviews were conducted. Each interview lasted between 45 and 60 minutes. Interviews were audio-recorded, transcribed verbatim, and analyzed using thematic content analysis. Thematic analysis was guided by the constructs of the Anderson and Newman Behavioural model of health service utilization.

Results
Utilization of sexual reproductive health services among female adolescents is low in the Tema metropolis. Factors such as unprotected non-consensual sexual activity or an unwanted pregnancy sometimes triggered the use of these services. Barriers to utilization identified include lack of awareness on sexual reproductive health services, unreliable sources of SRH information, underestimation of the severity of sexual reproductive health problems faced, unmet expectations and poor experiences with service providers.

Conclusion
The current study identified poor utilization of sexual reproductive health services among female adolescents within the Tema metropolis of Ghana. There is the need to increase the number of adolescent health corners, increase awareness about SRH services among adolescents, improve parent-child SRH communication and provide adequate training for healthcare providers to improve provider attitude towards adolescent SRH service delivery in order to increase utilization of sexual reproductive health services among female adolescents in the Metropolis.