bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between the tumor and its innervation: historical, methodical, morphological, and functional assessments – A minireview
Authors: Blasko Filip , Horvathova Lubica 
Published: April 2024

Abstract
The acceptance of the tumor as a non-isolated structure within the organism has opened a space for the study of a wide spectrum of potential direct and indirect interactions, not only between the tumor tissue and its vicinity, but also between the tumor and its macroenvironment, including the nervous system. Although several lines of evidence have implicated the nervous system in tumor growth and progression, for many years, researchers believed that tumors lacked innervation and the notion of indirect neuro-neoplastic interactions via other systems (e.g., immune, or endocrine) predominated. The original idea that tumors are supplied not only by blood and lymphatic vessels, but also autonomic and sensory nerves that may influence cancer progression, is not a recent phenomenon. Although in the past, mainly due to the insufficiently sensitive methodological approaches, opinions regarding the presence of nerves in tumors were inconsistent. However, data from the last decade have shown that tumors are able to stimulate the formation of their own innervation by processes called neo-neurogenesis and neo-axonogenesis. It has also been shown that tumor infiltrating nerves are not a passive, but active components of the tumor microenvironment and their presence in the tumor tissue is associated with an aggressive tumor phenotype and correlates with poor prognosis. The aim of the present review was to 1) summarize the available knowledge regarding the course of tumor innervation, 2) present the potential mechanisms and pathways for the possible induction of new nerve fibers into the tumor microenvironment, and 3) highlight the functional significance/consequences of the nerves infiltrating the tumors.
Regional Development Funds: Creation Rationale and Models of Operation
Authors: Radło Mariusz-Jan , Ignor Marek , Sum Katarzyna 
Published: April 2024

Abstract

Subject and purpose of work:
The purpose of the article is to present the creation of Regional Development Funds (Regionalne Fundusze Rozwoju - RFR) in Poland, their organisational models and factors influencing their development and choice of model. The research is also focused on the analysis of the variety of RFRs and their sources.

Materials and methods:
The research collects and presents data on RFRs operating in Poland, and analyses these data in the context of selected legal and administrative conditions.

Results:
The analysis showed significant variation among RFRs in terms of functional/ organisational models and scale of operation. The choice of an operating model for an RDF is influenced by factors such as the maturity of regional financial markets, the amount of RDF funds and the types of financial instruments offered.

Conclusions:
The study highlights the development of the financial market segment working with local authorities and businesses over the past decade. It draws attention to an increasing importance of financial instruments and institutions in development policies implemented by voivodeship governments.
The Role of the Local Government in Fostering Entrepreneurship – Evidence from Municipalities in the Kraków Metropolitan Area
Authors: Sroka Wojciech , Filipiak Tadeusz , Barczyk-Ciuła Justyna 
Published: April 2024

Abstract

Subject and purpose of work
The study was conducted in the municipalities of the Kraków Metropolitan Area. It aims to identify models for supporting local entrepreneurship and assess their effectiveness. The effectiveness of the models was evaluated by measuring the diversity and changes in the number of enterprises in the area. We also presented entrepreneurs’ opinions on their satisfaction with specific policies.

Materials and methods:
Secondary ( literature and statistical data) and primary data sources were used in the paper. The primary source was a survey among entrepreneurs. The survey research to assess the performance of entrepreneurship policy involved 21 municipalities. We apply a mixed-method approach here (comparative indicator analysis, cluster analysis and Kruskal-Wallis tests).

Results:
The research demonstrated that the policy involving entrepreneurship support through tax instruments (reduced local tax rates) does not contribute significantly to providing entrepreneurship-fostering conditions. The study revealed that the level of entrepreneurship may be affected more by the expenditure policy, such as the municipality’s efforts to establish special economic zones, organise training, establish business information points, etc.

Conclusions:
Local governments (LG) that are attractive to investors (such as easily available infrastructure and proximity to markets) should adopt high property-tax rates. The tax is undervalued in peri-urban municipalities (compared to property value) and does not burden the business. Second, LG should focus on hard projects. They should intensify spatial planning and land management to ensure space for business to grow. It will entail conflicts and balancing the needs of diverse social groups, but it must be done to stimulate local socioeconomic development.
Evaluation of the Pit Changes Introduced in 2022 as Part of the “Polish Deal”
Authors: Deresz Agnieszka Ewa , Podstawka Marian Grzegorz 
Published: April 2024

Abstract

Subject and purpose of work:
The subject of this paper is to evaluate the ‘Polish Deal’ programme introduced in 2022 in the tax area. The purpose of this article is to show the impact of the ‘Polish Deal’ legislation on net salaries of persons employed under an employment contract.

Materials and methods:
The paper is based on an analysis of legal provisions in the tax area, being one of the pillars of the ‘Polish Deal’. A simulation of the impact of the new tax rules on net salaries introduced from the beginning of January 2022 (‘Polish Deal 1’) and from the beginning of July 2022 (‘Polish Deal 2’) has been carried out.

Results:
The new personal taxation rules introduced by the ‘Polish Deal’ have contributed to an increase in net salaries of employees receiving a gross salary of less than PLN 12,000 per month and a reduction in the labour income of employees earning a salary above this amount.

Conclusions:
By strengthening the degree of progressivity, the reform of the tax system under the ‘Polish Deal’ has significantly affected the net income of natural persons receiving remuneration under an employment relationship. However, the new tax rules introduced in a fast-track manner by the ‘Polish Deal’ have raised a number of controversies among both employers and employees.
Assessing the Extent of Financial Inclusion Through Bank Office Expansion in Haryana
Authors: Rani Mamta , Siwach Manoj 
Published: April 2024

Abstract

Subject and purpose of work:
The study presents a comprehensive analysis of the banking sector in Haryana from 2007 to 2022.

Materials and methods:
The study is based on secondary data. The number of bank branches, deposits, and credits in the state are just a few economic indicators covered in the Statistical Abstract of Haryana. The compound growth rate is calculated to assess the growth of a bank.

Results:
The findings reveal a consistent rising trend in bank branches, credit and deposits of commercial banks. Notable trends include increasing bank branches, a surge in deposits and robust credit growth, indicating a dynamic and thriving banking sector. The Credit-Deposit ratio gradually increased from 2007 to 2011, reaching a peak in 2012 at 102.10%.

Conclusions:
The overall number of bank offices has increased dramatically due to the state’s growing financial sector. The steady expansion in bank branches indicates a sustained effort to improve accessibility and financial inclusion.
Anniversary Editorial: 15 Volumes of European Countryside Issued
Authors: Šťastná Milada , Vaishar Antonín , Pavlata Leoš 
Published: April 2024

Abstract
The paper evaluates the first 15 editions of the European Countryside magazine in relation to the EURORURAL conferences and international projects of the Department of Applied and Landscape Ecology of the Mendel University in Brno.
Challenges and Prospects for the Determinants of Socioeconomic Development in Rural Areas: Evidence from Lithuania
Authors: Lankauskienė Rita , Gedminaitė-Raudonė Živilė 
Published: April 2024

Abstract
This article presents the newly introduced model for EU policy-making, based on combined ‘bottom-up’ and ‘place-based’ approaches by establishing rural science-society-policy interfaces – Multi-Actor Platforms (MAPs). MAPs are open forums for exchanging relevant ideas in solving region’s most urgent place-based challenges, performing co-learning, and acting as knowledge co-creation platforms for the contribution of creating reflective research and policy agendas for the future of Europe’s rural areas. The main aim of this paper is to explore the challenges and prospects for the determinants of socioeconomic development (i.e., entrepreneurship, social economy, and sustainable and resilient value chains) in rural areas, based on SHERPA science-society-policy interface co-learning and co-creation results in Lithuanian MAP. Research results show that the combined bottom-up and place-based approaches with the help of regional MAPs as science-society-policy rural interfaces hold high potential to be applied to develop reflective research and policy agendas for the regions in the EU.
Bridging the Gap. Policies to Accelerate Social Change for an Inclusive Rural Digital Transformation in Sweden
Authors: Lindberg Johanna , Runardotter Mari , Ståhlbröst Anna 
Published: April 2024

Abstract
This study explores officials’ perspectives on Swedish policies for rural digital transformation (RDT). Through the lens of Social Acceleration and systems thinking, employing Critical Systems Heuristics collecting empirical data, we explore how officials perceive that Swedish digitalisation policies impacts inclusive RDT. We investigate whether the possibility to implement Swedish digitalisation policies support or hinder inclusive RDT. Our results emphasize the importance of Social Acceleration based on the aspirations of rural residents, encompassing technical acceleration, social change, and the pace of life. The rapid societal acceleration driven by digitalisation impacts the implementation of digital services in rural areas. Policies do not address the needs of tailored digital services; officials strive to manage this through creative methods despite inherent challenges.
‘Is Second the New First?’ – The Conversion of Second Homes Into Primary Ones During and After the COVID-19 Pandemic
Authors: Sulyok Judit , Nemes Gusztáv , Orbán Éva , Tomay Kyra 
Published: April 2024

Abstract
The COVID-19 pandemic has brought profound changes to the realm of second-home tourism, with far-reaching consequences for rural areas. Our quantitative survey of Hungary explores the multifaceted implications of this transformation along three axes: motivations, usage patterns, and future intentions. The results show that the COVID-19 pandemic has reinforced the trend of rural gentrification, turning many second-homes into permanent residences. Two locations play a crucial role in this phenomenon: Budapest as a source on the one hand, and traditional destinations, primarily Lake Balaton, on the other. The sudden increase of users posed challenges for the local infrastructure and public services, and the differences in values, preferences, and behaviour between new and old residents, may also create tensions and problems. Policymakers face the delicate task of balancing local needs with those of the burgeoning second-home population. Shaping a sustainable future for rural areas therefore requires strategic planning in order to amplify the positive impact and mitigate potential drawbacks.
Response of Short Food Supply Chains in Western Balkan Countries to the COVID Crisis: A Case Study in the Honey Sector
Authors: Paraušić Vesna , Dashi Etleva Muça , Subić Jonel , Pomianek Iwona , Šarić Bojana Bekić 
Published: April 2024

Abstract
Operation of short food supply chains (abbr. SFSCs) during the period of the pandemic caused by the SARS-CoV-2 virus provided a lesson which might be useful for perceiving the behaviour of farmers and local food systems in potential future crises caused by various endogenous or exogenous factors. A study based on a sample of 1081 beekeepers in Western Balkan countries shows how beekeepers involved in SFSCs perceived the influence of the pandemic on the growth of demand and sale of honey through these marketing channels. On the scale from 1 (no influence) to 7 (very strong influence), the average rating of 3.53 indicated a weak to moderate influence, which was fairly consistent across the countries of this region. The Kruskal-Wallis test and Mann-Whitney test determined that large-scale beekeepers, those in mountainous areas, those adding value to honey and beekeepers producing other bee products apart from honey stated that the pandemic had a stronger influence on the growth of demand and sale of honey through SFSCs. At the same time, a higher rating of the pandemic’s influence on sales growth was accompanied by greater limitations of beekeepers regarding the availability of family labour for selling honey, as well as by greater needs for digital marketing knowledge and skills. Binary logistic regression showed that the increase in beekeepers’ age led to the decreased rating of the influence of the pandemic on the growth of demand and sale of honey through SFSCs. It also showed that the influence rating rose with the increase in production capacity, adding value to honey and beekeepers’ needs for digital marketing knowledge and skills. The obtained results provide valuable knowledge about the potential response of SFSCs and involved producers to future crises and disruptions. It is primarily intended for policy makers, but also to practitioners and scientific and expert communities. All of them should respond proactively on behalf of society and prepare themselves for future challenges.
Transdisciplinary Research for Sustainable Development: Diverse and Best-Practice at European Technical Universities
Authors: LEURS Inge , ROSTEK Katarzyna , WIECK Kathrin , BACKHAUS Julia , OROZCO-MESSANA Javier 
Published: April 2024

Abstract
As societal challenges grow, so does the role of universities in finding social and technological solutions. Technical universities are prominent in educating future innovators and developing desired technological and social change. This paper seeks to identify commonalities and better understand differences to develop strategies for mutual support and exchange of best practices. The methodological approach focuses on three questions concerning 1) the common understanding of transdisciplinary, 2) the diversity of transdisciplinary approaches to sustainable development, and 3) the different institutional structures that enable and promote transdisciplinary approaches to sustainability. The qualitative exploratory research suggests that a higher level of societal engagement in scientific research positively impacts societal transformation towards sustainability. This research is also a first step towards making transdisciplinary research at technical universities more visible and transparent to provide better support and create a mutual learning environment for discussing and continuously developing strategies for organizational change.
Performance of green high-strength concrete incorporating palm oil fuel ash in harsh environments
Authors: Zeyad Abdullah M. , Johari Megat Azmi Megat , Aliakbar Ali , Magbool Hassan M. , Majid Taksiah A. , Aldahdooh Majed A. A. 
Published: April 2024

Abstract
The corrosion of steel reinforcement by chloride is commonly recognized as a key factor that contributes to the degradation of durability in reinforced concreae structures. Using supplementary cementitious materials, such as industrial and agricultural waste materials, usually enhances the impermeability of the concrete and its corrosion resistance, acid resistance, and sulfate resistance. This study’s primary purpose is to examine the effects of replacing ordinary Portland cement (OPC) with ultrafine palm oil fuel ash (U-POFA) on the corrosion resistant performance of high-strength green concrete (HSGC). There were four HSGC mixes tested; the first mix contained 100% OPC, while the other mixes replaced OPC mass with 20%, 40%, and 60% of U-POFA. The performance of all HSGC mixes containing U-POFA on workability, compressive strength, porosity, water absorption, impressed voltage test, and mass loss was investigated at 7, 28, 60, and 90 days. Adding U-POFA to mixes enhances their workability, compressive strength (CS), water absorption, and porosity in comparison with mixes that contain 100% OPC. The findings clearly portrayed that the utilization of U-POFA as a partial alternative for OPC significantly enhances the corrosion-resistant performance of the HSGC. In general, it is strongly advised that a high proportion of U-POFA be incorporated, totaling 60% of the OPC content. This recommendation is the result of its significance as an environmentally friendly and cost-effective green pozzolanic material. Hence, it could contribute to the superior durability performance of concrete structures, particularly in aggressive environmental exposures.

Highlights

The corrosion resistance performance of high-strength green concrete was investigated.

Ultrafine palm oil fuel ash as a partial alternative of cement mass with 20%, 40%, and 60% was used.

HSGC performance was evaluated in terms of workability, compressive strength, water absorption, porosity, impact stress testing, and mass loss.
Evaluation of the Effects of Gastro Protect as an Alternative Medicine on Gastritis and Other Gastrointestinal Symptoms
Authors: Nikolova Dafina , Trajkovska Meri , Trpcevska Emilija Nikolovska , Andreevski Vladimir , Stardelova Kalina Grivceva , Velic Vesna 
Published: April 2024

Abstract

Introduction:
The use of herbal medicine as a part of the Complementary and Alternative Medicine is increasing worldwide. Herbal remedies are used to better different conditions including gastritis.

Material and Methods:
We conducted a prospective randomized control clinical trial on a total sample of 72 patients with gastritis in order to examine the effects of the commercial herbal product Gastro Protect. After 6 weeks of conventional therapy the patients were divided into two groups with 36 patients each. As a continuation of the treatment, Group 1 received conventional therapy + Gastro Protect and Group 2 received conventional therapy + Placebo.
We analyzed 14 selected gastrointestinal symptoms, five related to digestive problems, and nine related to stool and bowel problems. For assessing the selected symptoms we used seven point gastrointestinal symptom rating scale (GSRS).

Results:
The Gastro Protect group had a significantly lower GSRS score (better condition) compared to the Placebo group related to all five selected symptoms of digestive problems as: abdominal pain (p=0.0250), hunger pain (p=0.0276), nausea (p=0.0019), heartburn (p=0.00001), and acid reflux (p=0.0017). The Gastro Protect group, also had a significantly lower GSRS score (better condition) compared to the Placebo group related to three out of nine selected bowel symptoms: rumbling (p=0.0022), abdominal distension (p=0.0029), and gas or flatus (p=0.0039).

Conclusion:
Gastro protect was effective in treating gastritis and other gastrointestinal symptoms. It was safe for usage and showed almost no side effects. In our study, Gastro Protect reduced the examined gastric symptoms and related examined intestinal symptoms.
Developing selection criteria for harmonious co-living: la Maison des Babayagas and beyond
Authors: Myers Marie J. , Xu Hui 
Published: April 2024

Abstract
With an ever-increasing pace of change, dwindling resources, and an aging population, modern societies face harsh questions regarding effective governance systems. Moreover, with lingering problems brought on by COVID and ongoing inflationary pressures, the situation for growing numbers of aging women who have outlived their partners and are living on their own is increasingly grim. In Canada, when the elderly cannot manage independently, even the least expensive full-care retirement home options can have a formidable cost, which can be a heavy burden for many. Therefore, it is of utmost importance for society to support independent living as long as possible.
Independent living models are being developed with various constraints and often with profit in mind. However, we were interested in the most economically feasible and socially acceptable solution. One such development is La Maison des Babayagas in Paris, France. This innovative government-subsidized housing project has been developed for retired independent women who pay rent for small apartments according to their means. The residents live in independent units and support one another in an economic and social arrangement that promotes friendships, fights loneliness, and helps each maintain a healthy outlook.
This research aimed to gather data to create an inventory questionnaire to select independent retired women in Canada to live together harmoniously in a housing project based on the successful model developed in Paris. The questionnaire is based on analyzing the Babayagas House charter and resident journals and an extensive review of related inventories and questionnaires. The criteria retained will be explained, and examples of the questions will be presented.
Environmental Audit as A Tool for Management and Sustainability: A Qualitative Study
Authors: Ferreira Allan Berthier Silva , Sebastiani Rafael Teixeira , Nascimento Leonardo Dias , Oliveira Keithy Juliane de , Carballo Fábio Peron , Zarpellon Cayttano Saul de Sá , Vitaliano Fabiana Carla Bezerra , Silva Ana Paula Stefanelo e , Nascimento Glauber Gonçalves do , Almeida-Bezerra José Weverton 
Published: April 2024

Objective: The present study sought to analyze the opportunities and challenges of environmental auditing in organizations.

Methodology: The research adopted an exploratory and descriptive approach to investigate the perceptions of fifteen managers regarding environmental auditing in a specific municipality in Brazil. Using qualitative methods, such as in-depth interviews, the interviews were conducted in a semi-structured manner, allowing managers to freely express their experiences and opinions on environmental auditing. The data were analyzed using the technique of discourse analysis.

Results and data analysis: Most managers see auditing as crucial to promote responsible environmental management, identify improvements and ensure legal compliance. However, they face significant challenges, such as the complexity of environmental regulations and implementation costs. These challenges require ongoing efforts to stay up-to-date and allocate adequate resources. Managers recognize legal compliance as essential to avoid penalties and protect the company's reputation.
Conclusion: The research offers theoretical and practical subsidies to organizations interested in strengthening their environmental practices, highlighting the importance of developing effective strategies and implementing sustainable practices.