bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing corporate brands through service robots: The impact of anthropomorphic design metaphors on corporate brand perceptions
Authors: Wünderlich Nancy V. , Blut Markus , Brock Christian 
Published: February 2024

AbstractThe increasing introduction of intelligent, interactive robots in the service industry raises concerns about the potential dehumanization of service provision and its influences on corporate brand perceptions. To avoid adverse effects, new service development (NSD) managers seemingly favor service robots that feature anthropomorphic design metaphors, so they appear more human‐like. The current research investigates explicitly how customers' perception of a robot's anthropomorphic design metaphors might spill over to affect corporate brand perceptions. Study 1, a picture‐based scenario study with 109 participants, reveals the impact of anthropomorphic design metaphors on untested corporate brand outcomes, such as brand trust and brand experience. Then Study 2, a video‐based scenario study with 530 participants, addresses whether these effects depend on the service context. In Study 3, a field study of 393 participants, the authors examine how anthropomorphic design metaphors influence other firm‐related outcomes (e.g., shopping enjoyment, sales). The combined results confirm that anthropomorphic design metaphors strongly affect brand trust and brand experience, as well as other critical firm‐related outcomes; they also reveal notable context effects, such that customers of people‐processing (e.g., care services) and mental‐stimulus‐processing (e.g., shopping assistance) services appear more likely to use anthropomorphic design metaphors as corporate brand cues. Our research encourages NSD managers and scholars to consider the effects of introducing anthropomorphic service robots on corporate brands.
The genetic basis of dispersal in a vertebrate metapopulation
Authors: Saatoglu Dilan , Lundregan Sarah L. , Fetterplace Evelyn , Goedert Debora , Husby Arild , Niskanen Alina K. , Muff Stefanie , Jensen Henrik 
Published: February 2024

AbstractDispersal affects evolutionary processes by changing population size and genetic composition, influencing the viability and persistence of populations. Investigating which mechanisms underlie variation in dispersal phenotypes and whether populations harbour adaptive potential for dispersal is crucial to understanding the eco‐evolutionary dynamics of this important trait. Here, we investigate the genetic architecture of dispersal among successfully recruited individuals in an insular metapopulation of house sparrows. We use an extensive long‐term individual‐based ecological data set and high‐density single‐nucleotide polymorphism (SNP) genotypes for over 2500 individuals. We conducted a genome‐wide association study (GWAS), and found a relationship between dispersal probability and a SNP located near genes known to regulate circadian rhythm, glycogenesis and exercise performance, among other functions. However, this SNP only explained 3.8% of variance, suggesting that dispersal is a polygenic trait. We then used an animal model to estimate heritable genetic variation (σA2), which composes 10% of the total variation in dispersal probability. Finally, we investigated differences in σA2 across populations occupying ecologically relevant habitat types (farm vs. non‐farm) using a genetic groups animal model. We found different adaptive potentials across habitats, with higher mean breeding value, σA2, and heritability for the habitat presenting lower dispersal rates, suggesting also different roles of environmental variation. Our results suggest a complex genetic architecture of dispersal and demonstrate that adaptive potential may be environment dependent in key eco‐evolutionary traits. The eco‐evolutionary implications of such environment dependence and consequent spatial variation are likely to become ever more important with the increased fragmentation and loss of suitable habitats for many natural populations.
Genomic and metabolomic diversity within a familial population of Aspergillus flavus
Authors: Moore Geromy G. , Mack Brian M. , Wendt Karen L. , Castano‐Duque Lina , Anderson Victoria M. , Cichewicz Robert H. 
Published: February 2024

AbstractAspergillus flavus is an agriculturally significant micro‐fungus having potential to contaminate food and feed crops with toxic secondary metabolites such as aflatoxin (AF) and cyclopiazonic acid (CPA). Research has shown A. flavus strains can overcome heterokaryon incompatibility and undergo meiotic recombination as teleomorphs. Although evidence of recombination in the AF gene cluster has been reported, the impacts of recombination on genotype and metabolomic phenotype in a single generation are lacking. In previous studies, we paired an aflatoxigenic MAT1‐1 A. flavus strain with a non‐aflatoxigenic MAT1‐2 A. flavus strain that had been tagged with green fluorescent protein and then 10 F1 progenies (a mix of fluorescent and non‐fluorescent) were randomly selected from single‐ascospore colonies and broadly examined for evidence of recombination. In this study, we determined four of those 10 F1 progenies were recombinants because they were not vegetatively compatible with either parent or their siblings, and they exhibited other distinctive traits that could only result from meiotic recombination. The other six progenies examined shared genomic identity with the non‐aflatoxigenic, fluorescent, and MAT1‐2 parent, but were metabolically distinct. This study highlights phenotypic and genomic changes that may occur in a single generation from the outcrossing of sexually compatible strains of A. flavus.
Circadian rhythm and whole gut transit in mice
Authors: Laible Emma , Wegner Andrew , Knutson Kaitlyn , Kacmaz Halil , Garramone Gwyneth K. , Gogineni Kamalika , Matveyenko Aleksey , Linden David R. , Farrugia Gianrico , Beyder Arthur 
Published: February 2024

AbstractBackgroundIn preclinical studies whole gut transit (WGT) in mice is a gold‐standard “leading‐edge” approach that measures the time between orogastric gavage of carmine red and defecation of the first carmine red pellet. Transit studies in humans are performed during the active day because GI motility and transit are suppressed during the night. Since mice are nocturnal, WGT studies traditionally done during the day occur during their rest phase. How circadian rhythm affects WGT in mice is not known.MethodsWe used an automated approach for high temporal resolution uninterrupted testing of mouse WGT and activity. We housed wild‐type Bl6/C57 mice under the standard 12 h light–dark cycles. At 8 weeks, we performed carmine red orogastric gavage and assessed WGT during Light (rest) conditions. Then, we exposed mice to a reverse 12 h light–dark cycle for 2 weeks and tested them in the Dark (active) under red light conditions. Timelapse videos were analyzed to quantify activity and to timestamp all pellets, and multiple parameters were analyzed.Key ResultWhen complementary light cycle reversal experiments were performed, we found a significant increase in mouse activity when mice were tested during their Dark (active) phase, compared to their Light (rest) phase. In mice tested in the Active phase compared to the Rest phase, we found a significant acceleration in WGT, increased rate and total number of pellets produced, and more pellet clustering. These data show that the mice tested in the Active phase have important differences in activity that correlate with multiple alterations in gastrointestinal transit.Conclusion & InferencesDuring the Active phase mice have faster WGT, produce more pellets, and cluster their output compared to testing in the Rest phase. Like in humans, circadian rhythm is an important consideration for transit studies in mice, and a simple reverse light cycle approach facilitates further studies on the role of circadian rhythm in GI motility.
Plant size‐dependent influence of foliar fungal pathogens promotes diversity through allometric growth
Authors: Xiao Yao , Liu Xiang , Song Zhiping , Lu Yawen , Zhang Li , Huang Mengjiao , Cheng Yikang , Chen Shiliang , Zhao Yimin , Zhang Zhenhua , Zhou Shurong 
Published: February 2024

Summary
The effect of pathogens on host diversity has attracted much attention in recent years, yet how the influence of pathogens on individual plants scales up to affect community‐level host diversity remains unclear.
Here, we assessed the effects of foliar fungal pathogens on plant growth and species richness using allometric growth theory in population‐level and community‐level foliar fungal pathogen exclusion experiments. We calculated growth scaling exponents of 24 species to reveal the intraspecific size‐dependent effects of foliar fungal pathogens on plant growth. We also calculated the intercepts to infer the growth rates of relatively larger conspecific individuals.
We found that foliar fungal pathogens inhibited the growth of small conspecific individuals more than large individuals, resulting in a positive allometric growth. After foliar fungal pathogen exclusion, species‐specific growth scaling exponents and intercepts decreased, but became positively related to species' relative abundance, providing a growth advantage for individuals of abundant species with a higher growth scaling exponent and intercept compared with rare species, and thus reduced species diversity.
By adopting allometric growth theory, we elucidate the size‐dependent mechanisms through which pathogens regulate species diversity and provide a powerful framework to incorporate antagonistic size‐dependent processes in understanding species coexistence.
Major quality regulation network of flavonoid synthesis governing the bioactivity of black wolfberry
Authors: Du Youwei , Ma Huiya , Liu Yuanyuan , Gong Rui , Lan Yu , Zhao Jianhua , Liu Guangli , Lu Yiming , Wang Shuanghong , Jia Hongchen , Li Na , Zhang Rong , Wang Junru , Sun Guangyu 
Published: February 2024

Summary
Black wolfberry (Lycium ruthenicum Murr.) contains various bioactive metabolites represented by flavonoids, which are quite different among production regions. However, the underlying regulation mechanism of flavonoid biosynthesis governing the bioactivity of black wolfberry remains unclear.
Presently, we compared the bioactivity of black wolfberry from five production regions. Multi‐omics were performed to construct the regulation network associated with the fruit bioactivity. The detailed regulation mechanisms were identified using genetic and molecular methods.
Typically, Qinghai (QH) fruit exhibited higher antioxidant and anti‐inflammatory activities. The higher medicinal activity of QH fruit was closely associated with the accumulation of eight flavonoids, especially Kaempferol‐3‐O‐rutinoside (K3R) and Quercetin‐3‐O‐rutinoside (rutin). Flavonoid biosynthesis was found to be more active in QH fruit, and the upregulation of LrFLS, LrCHS, LrF3H and LrCYP75B1 caused the accumulation of K3R and rutin, leading to high medicinal bioactivities of black wolfberry. Importantly, transcription factor LrMYB94 was found to regulate LrFLS, LrCHS and LrF3H, while LrWRKY32 directly triggered LrCYP75B1 expression. Moreover, LrMYB94 interacted with LrWRKY32 to promote LrWRKY32‐regulated LrCYP75B1 expression and rutin synthesis in black wolfberry. Transgenic black wolfberry overexpressing LrMYB94/LrWRKY32 contained higher levels of K3R and rutin, and exhibited high medicinal bioactivities. Importantly, the LrMYB94/LrWRKY32‐regulated flavonoid biosynthesis was light‐responsive, showing the importance of light intensity for the medicinal quality of black wolfberry.
Overall, our results elucidated the regulation mechanisms of K3R and rutin synthesis, providing the basis for the genetic breeding of high‐quality black wolfberry.
Stomatal response to VPD is not triggered by changes in soil–leaf hydraulic conductance in Arabidopsis or Callitris
Authors: Bourbia Ibrahim , Brodribb Timothy J. 
Published: February 2024

Summary
Stomatal closure under high VPDL (leaf to air vapour pressure deficit) is a primary means by which plants prevent large excursions in transpiration rate and leaf water potential (Ψleaf) that could lead to tissue damage. Yet, the drivers of this response remain controversial. Changes in Ψleaf appear to drive stomatal VPDL response, but many argue that dynamic changes in soil‐to‐leaf hydraulic conductance (Ks‐l) make an important contribution to this response pathway, even in well‐hydrated soils.
Here, we examined whether the regulation of whole plant stomatal conductance (gc) in response to typical changes in daytime VPDL is influenced by dynamic changes in Ks‐l. We use well‐watered plants of two species with contrasting ecological and physiological features: the herbaceous Arabidopsis thaliana (ecotype Columbia‐0) and the dry forest conifer Callitris rhomboidea.
The dynamics of Ks‐l and gc were continuously monitored by combining concurrent in situ measurements of Ψleaf using an open optical dendrometer and whole plant transpiration using a balance. Large changes in VPDL were imposed to induce stomatal closure and observe the impact on Ks‐l.
In both species, gc was observed to decline substantially as VPDL increased, while Ks‐l remained stable. Our finding suggests that stomatal regulation of transpiration is not contingent on a decrease in Ks‐l. Static Ks‐l provides a much simpler explanation for transpiration control in hydrated plants and enables simplified modelling and new methods for monitoring plant water use in the field.
Cell‐layer specific roles for gibberellins in nodulation and root development
Authors: Velandia Karen , Correa‐Lozano Alejandro , McGuiness Peter M. , Reid James B. , Foo Eloise 
Published: February 2024

Summary
Gibberellins (GA) have a profound influence on the formation of lateral root organs. However, the precise role this hormone plays in the cell‐specific events during lateral root formation, rhizobial infection and nodule organogenesis, including interactions with auxin and cytokinin (CK), is not clear.
We performed epidermal‐ and endodermal‐specific complementation of the severely GA‐deficient na pea (Pisum sativum) mutant with Agrobacterium rhizogenes. Gibberellin mutants were used to examine the spatial expression pattern of CK (TCSn)‐ and auxin (DR5)‐responsive promoters and hormone levels.
We found that GA produced in the endodermis promote lateral root and nodule organogenesis and can induce a mobile signal(s) that suppresses rhizobial infection. By contrast, epidermal‐derived GA suppress infection but have little influence on root or nodule development. GA suppress the CK‐responsive TCSn promoter in the cortex and are required for normal auxin activation during nodule primordia formation.
Our findings indicate that GA regulate the checkpoints between infection thread (IT) penetration of the cortex and invasion of nodule primordial cells and promote the subsequent progression of nodule development. It appears that GA limit the progression and branching of IT in the cortex by restricting CK response and activate auxin response to promote nodule primordia development.
Novel scoring system derived from meta‐analysis and validated in cohort population for predicting 1‐year atrial fibrillation recurrence after cryoballoon catheter ablation: The HeLPS‐Cryo score
Authors: Waranugraha Yoga , Hsu Jung‐Chi , Lin Ting‐Tse , Ho Li‐Ting , Yu Chih‐Chieh , Liu Yen‐Bin , Lin Lian‐Yu 
Published: February 2024

AbstractBackgroundAtrial fibrillation (AF) recurrence rates in 1 year after cryoballoon ablation catheter (CBCA) are still high. We purposed to identify strong predictors for AF recurrence after the successful CBCA procedure and develop a new scoring system based only on pre‐procedural parameters.MethodsIn the derivation phase, a systematic review and meta‐analysis identified the strong predictors of AF recurrence after the CBCA. The pooled hazard ratio (HR) was used to create the new scoring system. The second phase validated the new scoring system in the cohort population.ResultsA meta‐analysis including 29 cohort studies with 16196 participants confirmed that persistent AF, stroke, heart failure, and left atrial diameter (LAD) >40 mm were powerful predictors for AF recurrence after the CBCA procedure. The HeLPS‐Cryo (heart failure [1], left atrial dilatation [1], persistent AF [2], and stroke [2]) was developed based on those pre‐procedural predictors. It was validated in 140 patients receiving CBCA procedures and revealed excellent predictive performance for 1‐year AF recurrence (AUC = 0.8877; 95% CI = 0.8208 to 0.9546). The HeLPS‐Cryo score of ≥3 could predict 1‐year AF recurrence with sensitivity and specificity of 78.9% and 87.9%, respectively. The positive predictive value was 66.7%, and the negative predictive value was 93.1%.ConclusionThe HeLPS‐Cryo score can help the physician estimate the probability of 1‐year AF recurrence after the successful CBCA procedure. Patients with HeLPS‐Cryo score <3 are good candidates for the CBCA procedure.
Management of the sensitized pediatric renal transplant candidate
Authors: Puliyanda Dechu P. , Jordan Stanley C. 
Published: February 2024

AbstractKidney transplantation is the treatment of choice for patients with ESRD as it is associated with improved patient survival and better quality of life, especially in children. There are several barriers to a successful transplant including organ shortage, anatomic barriers, and immunologic barriers. One of the biggest immunologic barriers that precludes transplantation is sensitization, when patients have antibodies prior to transplantation, resulting in positive crossmatches with donor. 30%–40% of adult patients on the wait list are sensitized. There is a growing number of pediatric patients on the wait list who are sensitized. This poses a unique challenge to the pediatric transplant community. Therefore, attempts to perform desensitization to remove or suppress pathogenic HLA antibodies resulting in acceptable crossmatches, and ultimately a successful transplant, while reducing the risk of acute rejection, are much needed in these children. This review article aims to address the management of such patients both prior to transplantation, with strategies to overcome sensitization, and after transplantation with monitoring for allograft rejection and other complications.
Antiradical capacity assay for hydrophobic substances using hemin‐catalyzed luminol chemiluminescence in cationic micelles
Authors: Santos Cerize S. , Lemos Marcos P. O. , Betschart Larissa M. , Baader Wilhelm J. 
Published: February 2024

AbstractAntioxidant substances which can diminish the steady‐state concentration of free radicals in vivo are important in the human dietary to diminish the deleterious effects of oxidative stress. As the potential of certain substances as antioxidants is difficult to be verified in vivo, simple chemical in vitro assays which test the potential of substances as antioxidants are of great importance for the screening of new antioxidants. These assays measure the capacity of a substance to suppress free radicals. We describe here an antiradical capacity assay, based on luminol chemiluminescence, in cationic micellar medium, allowing the capacity determination of hydrophobic compounds. The antiradical capacity of antioxidants is determined using the Trolox standard by the measurement of the light emission inhibition area caused by the addition of different antiradical concentrations. The obtained results are compared to the values determined using the scavenging of stable free radicals be the substances and shown to be similar for compounds like uric acid, rutin, and quercetin. However, for vitamin E, the luminol assay results in a considerably higher antiradical capacity than the assay with a stable free radical, which is rationalized by the higher reactivity of the radical generated in the luminol assay and a specific localization of vitamin E in the micellar medium.
Does anxiety increase policy learning?
Authors: Lablih Moulay , Bundi Pirmin , Portmann Lea 
Published: February 2024

AbstractDoes anxiety affect how public officials process policy information? It is often argued that the increasing number of policy failures can be explained by a lack of policy learning by decision makers. While previous studies show that socioeconomic and partisan variables are related to the perception of policy information, little attention has been paid to the role of emotions, such as anxiety, in the policymaking process. In this paper, we investigate the impact of anxiety on the policy learning of local office holders at the individual level in Switzerland. We introduce the Marcus' Affective Intelligence Model—which examines how emotions affect individuals' information processing—to the policy learning literature. To test the expectations of the model, we draw on novel experimental data collected among local elected officials from the 26 Swiss cantons. In the experiment, we randomly display anxiety‐inducing images along with policy information. We provide evidence that anxiety has a positive causal effect on learning. Considering potential moderators of this effect, we show that the relationship is not conditioned by the strength of priors or the perceived complexity of public policies. However, these variables are substantially correlated with policy learning. Our findings have important implications for better understanding how information influences policymaking.
Primitive reflexes and dementia in older adults: a meta‐analysis of observational and cohort studies
Authors: Altunkalem Seydi Kübra , Kaya Derya , Yavuz Idil , Ontan Mehmet Selman , Dost Fatma Sena , Isik Ahmet Turan 
Published: February 2024

AbstractPrimitive reflexes (PRs) are clinical signs that indicate diffuse cerebral dysfunction and frontal lesions. We aimed to present a comprehensive analysis of the prevalence and risk of PRs in patients with dementia. English‐language articles published from January 1990 to April 2021 were searched in PubMed, ScienceDirect, Cochrane, and Web of Science with keywords. The titles and abstracts of the identified articles were screened to identify potentially relevant papers. Odds ratios and risk ratios were extracted with 95% confidence intervals and combined using the random‐effects model after logarithmic transformation. The prevalence in dementia patients was also combined using the random‐effects model. This meta‐analysis involved 29 studies. The snout reflex (48% of cases) was the most prevalent. It was found that the risk of PRs in individuals with dementia was significantly elevated, ranging from 13.94 to 16.38 times higher than in healthy controls. The grasp reflex exhibited the highest risk for dementia. This meta‐analysis showed that the prevalence and the risk of PRs is high in older patients with dementia. Therefore, PRs, especially the grasp reflex, should be carefully assessed as a part of routine physical examination in the diagnostic process for dementia.
The harmonious soul and the defence of music in sixteenth‐century England
Authors: Butler Katherine 
Published: February 2024

AbstractThis article examines the history of the concept of the soul as a harmony—as opposed to merely being like a harmony—in sixteenth‐century England, demonstrating how debates over music's morality in sixteenth‐century England were a catalyst for theorising an increasing affinity between music and the soul. At the beginning of the sixteenth century, English writers valued music primarily for its restorative qualities or its potential to instil virtue, akin to arguments in Aristotle's Politics. As attacks on music intensified mid‐century, defenders turned to more Platonic views of music, gradually going as far as arguing that the soul itself was a harmony. As I demonstrate, however, music's defenders trod a fine line in using this concept, which had been challenged since classical times and caused problems for Christian theology and the notion of the immortal soul. Nevertheless, by the seventeenth century, the pervasiveness of the language of soul‐harmony was such that it continued to be influential in the seventeenth century as a tool for conveying the emerging new medical and cognitive theories.