bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating pediatric ureteropelvic junction obstruction: Dynamic magnetic resonance urography vs renal scintigraphy 99m-technetium mercaptoacetyltriglycine
Authors: Al-Shaqsi Yousuf , Peycelon Matthieu , Paye-Jaouen Annabel , Carricaburu Elisabeth , Tanase Anca , Grapin-Dagorno Christine , El-Ghoneimi Alaa 
Published: March 2024

BACKGROUND
Ureteropelvic junction obstruction (UPJO) is a common congenital urinary tract disorder in children. It can be diagnosed as early as in utero due to the presence of hydronephrosis or later in life due to symptomatic occurrence.
AIM
To evaluate the discrepancy between dynamic contrast-enhanced magnetic resonance urography (dMRU) and scintigraphy 99m-technetium mercaptoacetyltriglycine (MAG-3) for the functional evaluation of UPJO.
METHODS
Between 2016 and 2020, 126 patients with UPJO underwent surgery at Robert Debré Hospital. Of these, 83 received a prenatal diagnosis, and 43 were diagnosed during childhood. Four of the 126 patients underwent surgery based on the clinical situation and postnatal ultrasound findings without undergoing functional imaging evaluation. Split renal function was evaluated preoperatively using scintigraphy MAG-3 (n = 28), dMRU (n = 53), or both (n = 40). In this study, we included patients who underwent surgery for UPJO and scintigraphy MAG-3 + dMRU but excluded those who underwent only scintigraphy MAG-3 or dMRU. The patients were divided into groups A (< 10% discrepancy) and B (> 10% discrepancy). We examined the discrepancy in split renal function between the two modalities and investigated the possible risk factors.
RESULTS
The split renal function between the two kidneys was compared in 40 patients (28 boys and 12 girls) using scintigraphy MAG-3 and dMRU. Differential renal function, as determined using both modalities, showed a difference of < 10% in 31 children and > 10% in 9 children. Calculation of the relative renal function using dMRU revealed an excellent correlation coefficient with renal scintigraphy MAG-3 for both kidneys.
CONCLUSION
Our findings demonstrated that dMRU is equivalent to scintigraphy MAG-3 for evaluating split renal function in patients with UPJO.
Ductal carcinoma in situ within a fibroadenoma: A case report and review of literature
Authors: Olivares-Antúnez Yazmin , Dávila-Zablah Yesika Janett , Vázquez-Ávila José Raúl , Gómez-Macías Gabriela Sofía , Mireles-Aguilar María Teresa , Garza-Montemayor Margarita Lilia 
Published: March 2024

BACKGROUND
Fibroadenoma (FA) is the most common tumor found in young women, although it can occur in any age group. Ductal carcinoma in situ (DCIS) that is confined in a FA is rare; it is most frequently reported as an incidental finding.
CASE SUMMARY
We report a case of DCIS within a FA in a 46-year-old female without cancer-related personal and family histories. The patient was diagnosed with a breast conglomerate of nodules and was followed for 1 year. In the current control image study, we found suspicious microcalcification, as a new finding, within one of the nodules. Consequently, a core biopsy of the tumor, which appeared hypoechoic, oval, and circumscribed, was performed. The pathological diagnosis was ductal carcinoma in situ within a fibroepithelial lesion. The patient underwent breast-conserving surgery and received radiotherapy as well as endocrine therapy (tamoxifen).
CONCLUSION
We recommend a multidisciplinary approach for adequate treatment and follow-up.
Moralitas dan Spiritualitas Pantekosta dalam Kisah Para Rasul 2:1-47
Authors: Winanto Natanael , Bulan Susanti Embong 
Published: March 2024

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Pentecostalism, a movement that lived from the beginning, viewed the first-century church, mentioned in acts, as its paradigm. This study aims to explain morality and Pentecostal spirituality in Acts 2: 1-47. The research method used is literature review of Pentecostal morality and spirituality and Acts 2:1-47. The result is the first part of this article on the paradigm of Acts 2:1-47 which describes the charismatic empowerment of the Holy Spirit, the manifest manifestation of the gift, the mission in terms of spiritualistas. The second part addresses unique aspects of Pentecostal spirituality as a result of the paradigm of Acts 2:1-48. Pentecostal spirituality in Acts 2 is a new interpretation of the phenomenon that occurred in the early church era until today. The phenomenon is alive and moving continuously across the ages. Until finally gave birth to a contemplation, study and gave birth to a new understanding in Christianity.

Pentakostalisme, sebuah gerakan yang hidup sejak awal, memandang gereja abad pertama, yang disebutkan dalam Kisah Para Rasul, sebagai paradigmanya. Kajian ini bertujuan menjelaskan moralitas dna spiritualitas Pantekosta dalam Kisah Para Rasul 2:1-47. Metode penelitian yang digunakan adalah kajian literatur moralitas dan spiritualitas Pantekosta dan Kisah Para Rasul 2:1-47. Bagian pertama dari artikel ini tentang paradigma Kisah Para Rasul 2:1-47 yang menggambarkan pemberdayaan karismatik Roh Kudus, manifestasi nyata dari karunia, misi dalam hal spiritualistas. Bagian kedua membahas aspek-aspek unik dari spiritualitas Pantekosta sebagai hasil dari paradigma Kisah Para Rasul 2:1-48. Hasilnya adalah spiritualitas Pantekosta dalam Kisah Para Rasul 2 merupakan pemaknaan baru terhadap fenomena yang terjadi di era jemaat awal hingga saat ini. Fenomena itu hidup dan bergerak terus melintasi zaman. Hingga akhirnya melahirkan sebuah perenungan, pengkajian dan melahirkan pemahaman baru dalam kekristenan.
Purification and Biochemical Characterization of Phytase Enzyme from Lactobacillus brevis Isolated from Fresh Kashar Cheese
Authors: Dikbaş Neslihan , Alım Şeyma , Uçar Sümeyra , Uçar Sevda , Kasapoğlu Ayşe Gül , Yigider Esma 
Published: March 2024

In the last 20 years, phytase enzyme has attracted the attention of scientists in the fields of environmental protection, nutrition and biotechnology. Myo-inositol hexaphosphate phosphohydrolase (phytase), which is a type of phosphatase enzyme, catalyzes the hydrolysis of phytate into less phosphorylated inorganic phosphates and phytate. Phytases of microbial origin are widely used in biotechnological applications (paper industry, feed industry, food industry and soil improvement).
In the present study, phytase enzyme was partially purified from Lactobacillus brevis NM-34 strain isolated from fresh kashar cheese and the pH and temperature values at which the enzyme showed optimum activity were determined. L. brevis NM-34 showed a phytase activity of 243.80 U/mL as a result of ammonium sulfate precipitation. In the ammonium sulfate range (40-60%), where the highest phytase activity was observed, the protein concentration was measured as 0.989 mg/mL. Km and Vmax values of phytase enzyme were determined as 0.0146 mM and 1.6 µmol/min, respectively. The pH and temperature values at which the partially purified phytase showed optimum activity were found to be pH 5 and 50 °C, respectively. Based on the findings from our research, the enzyme purified from this bacterium was found to have unique properties that make it suitable for use in industrial applications.
PEMILIHAN KEPALA DAERAH DALAM KERANGKA NEGARA DEMOKRASI PANCASILA
Authors: Ninik Hasanah  , Rian Hidayat  , Sarbani  , Andi Supriansyah  , Ahmad Safei  , Purnama Adi 
Published: March 2024

AbstrakPancasila adalah dasar Negara yang disahkan PPKI tanggal 18 Agustus 1945 sebagai satu kesatuan dengan UUD 1945, wajib dijadikan dasar penyelenggaraan negara dalam seluruh aspek kehidupan. Pancasila sebagai sumber dari segala sumber hukum sebagaimana diatur dalam Pasal 2 UU 12/2011, wajib di jadikan sebagai rujukan penyusunan seluruh peraturan perundang-undangan, termasuk UU Pemilu maupun UU Pilkada. Pilkada langsung adalah wujud nyata dari pembentukan demokratisasi di daerah.Pemilihan Kepala Daerah secara langsung harus dimasukkan dalam kerangka besar untuk mewujudkan pemerintahan lokal yang demokratis.Tujuan diadakannya pilkada langsung adalah untuk membentuk pemerintahan yang kuat berdasarkan pilihan dan legitimasi dari rakyat.Pilkada langsung adalah wujud nyata dari pembentukan demokratisasi di daerah.Partisipasi warga dalam pemilhan diharapkan tinggi sehinggga hasil pemilihan mempunyai legitimasi kuat. Namun demikian partisipasi warga masyarakat dalam memilih harus tetap berada pada koridor kebebasan politik dan kebebasan sipilnya, tanpa takut akan intimidasi, tetap mempunyai rasa aman. Karena sistem politik demokratis ciri khasnya terletak pada tatanan demokratis yang melandasi penguasa sehingga elemen-elemen demokrasi tidak saja menjadi norma bernegara tetapi secara empirik bekerja sesuai dengan koridor demokrasi.
Kata Kunci : Pancasila; Pilkada; Demokratis; Demokrasi
Anti-programmed-death-receptor-1 (PD-1) antibody (Pembrolizumab) induced pancreatitis diagnosed on 18F-FDG PET/CT
Authors: Sharjeel Usmani  , Anjali Jain  , Khulood Al Riyami  , Raza Sayani  , Vipin V Jayakrishan  
Published: March 2024

Immunotherapy related adverse events are commonly seen with immune check point inhibitors therapy. We report the case of a 40-year-old female diagnosed with stage IVB endometroid grade III endometrial cancer, on pembrolizumab immunotherapy, an anti-programmed-death-receptor-1 (PD-1) antibody. Patient was referred for 18F-FDG PET/CT for restaging. 18F-FDG PET/CT demonstrated diffuse increased FDG uptake throughout the body of the pancreas associated with fat stranding in the peripancreatic region, suggestive of pembrolizumab-induced pancreatitis. The diagnosis was confirmed by elevated amylase and lipase levels. Immune-related adverse events are frequently identified on 18F-FDG PET-CT, which may lead to early diagnosis, close clinical follow-up, and appropriate clinical management of immune-related adverse events.
Key Words: 18F-FDG PET/CT; pembrolizumab; pancreatitis; anti-programmed-death-receptor-1 (PD-1) antibody
Development of marketing of territories in the context of the implementation of environmental priorities
Authors: Антонов В.Н. 
Published: March 2024

В статье определено, что при формировании программы развития территорий на основе маркетинговых стратегий важно обратить внимание на решение вопросов экологизации территорий. Для реализации экологических приоритетов необходимо проводить организационные мероприятия с реализацией основных задач зеленого имиджа территорий и разработкой соответствующего бренда территории, что влияет на активизацию взаимодействия с целевыми аудиториями, непосредственно с инвесторами, которые с целью реализации экологических требований на протяжении всего цикла выполнения взаимосвязанных задач прилагают максимальные усилия по реализации планов развития маркетинга территорий. Уточнены недостатки внедрения инноваций в маркетинге территорий и взаимодействия заинтересованных лиц в реализации экологической политики развития территорий. Предложенные стратегические направления развития маркетинга территорий, которые направлены на реализацию экологических приоритетов, являются вектором дальнейших научных исследований.
The article determines that when forming a territorial development program based on marketing strategies, it is important to pay attention to solving issues of greening territories. To implement environmental priorities, it is important to carry out organizational measures with the implementation of the main tasks of the green image of the territories and the development of an appropriate brand of the territory, which affects the activation of interaction with target audiences, directly with investors, who, in order to implement environmental requirements throughout the entire cycle of interrelated tasks, make maximum efforts to implement plans for the development of marketing territories in order to solve problems to fulfill environmental priorities. The disadvantages of organizing the introduction of innovations in the marketing of territories and the interaction of stakeholders in the implementation of environmental policy for the development of territories are clarified. The formed and proposed strategic directions for the development of territory marketing, which are aimed at implementing environmental priorities, are a vector for further scientific research.
Methodological aspects of regional economic policy based on the orientation of business structures
Authors: Полянин А.В. , Родионов Д.Г. 
Published: March 2024

В статье рассмотрены методологические аспекты региональной экономической политики на основе ориентации предпринимательских структур, при этом исследуются принципы и подходы, которые используются для разработки и реализации политики, направленной на поддержку предпринимательства в региональной экономике. Анализируются методологические аспекты такой политики, такие как стимулирование предпринимательства, содействие инновациям и технологическому развитию, развитие человеческого капитала, регулятивные меры и стимулирование конкуренции. Обсуждаются меры, которые могут быть приняты региональными властями для создания благоприятной среды для предпринимательства, такие как снижение барьеров для бизнеса, финансовая поддержка, образовательные программы и меры по борьбе с недобросовестной конкуренцией. В частности, аспекты такой политики охватывают несколько ключевых направлений: анализ и оценка потенциала предпринимательских структур, формирование и поддержка бизнес-среды, содействие инновационному развитию и привлечение инвестиций. Основываясь на этих методологических аспектах, предлагаются рекомендации по формированию политики, способствующей развитию предпринимательства и устойчивому росту региональной экономики.
The article examines the methodological aspects of regional economic policy based on the orientation of entrepreneurial structures, while the author explores the principles and approaches that are used to develop and implement policies aimed at supporting entrepreneurship in the regional economy. The author of the article analyzes the methodological aspects of such a policy, such as stimulating entrepreneurship, promoting innovation and technological development, developing human capital, regulatory measures and stimulating competition. The article discusses measures that can be taken by regional authorities to create a favorable environment for entrepreneurship, such as reducing barriers to business, financial support, educational programs and measures to combat unfair competition. In particular, aspects of such a policy cover several key areas: analysis and assessment of the potential of entrepreneurial structures, formation and support of the business environment, promotion of innovative development and attraction of investments. Based on these methodological aspects, the article offers recommendations for the formation of policies that promote the development of entrepreneurship and sustainable growth of the regional economy.
EXAMINING THE SUSTAINABLE GROWTH OF AGRICULTURAL TOURISM IN THE STATE OF MAHARASHTRA
Authors: Chowdhury Abhishek 
Published: March 2024

Background: Agritourism, the fusion of agriculture and tourism, has gained prominence as a unique travel experience offering rural settings and agricultural activities to tourists. This study focuses on the sustainable growth of agritourism, particularly in Maharashtra, India. Objectives: To investigate the scope of agri tourism and to study the potential of agritourism in domestic market. Methodology: Research design was descriptive in nature. The study was conducted in the cities of the state of Maharashtra: Pune, Aurangabad, Nagpur, Thane, Raigad, Pune, and Satara. 125 potential tourist were selected for the study. The samples were selected on the basis of convenience sampling technique. Tool used for collection of data was online questionnaire. Data was analyzed on the basis age, gender, educational qualification, annual income & place of residents of the respondents and statistical analysis was done on percentage basis. Results: It was found that 72% of the respondents were aware of the concept of agritourism. The interest level of the potential tourist in various activities of agritourism varied: 22.3% of the respondents were interested in tasting local food, learning local culture & tradition response percentage was 17.8%, for learning local cooking it was 17.5%, relaxation was 16%, farming experiences was 13.2%, and participation in local handicraft response percentage was 10.5%. Conclusion: The study concluded that agritourism holds significant potential in India, offering additional income opportunities for farmers and enhancing rural economies. Recommendations include the establishment of collaborative societies, government support, and strategic partnerships to promote and sustain agritourism development in Maharashtra and beyond.
Captive Lifestyle of Reptiles in the Tashkent Zoo
Authors: Khonnazarova Mamlakat T. 
Published: March 2024

As we know, ancient reptiles - Cotylosaurs - evolved from Stegocephalus in the Middle Carboniferous period. Stegocephalus later divided into 2 branches; from one of them - mammals, and the other - birds. Reptiles (Reptilia) belong to the class of vertebrates. Currently, there are 3 zoos in the Republic of Uzbekistan. These zoos are located in Surkhandarya region, Fergana region, and the city of Tashkent. In total, these zoos contain 14,443 species of animals. 304 of them are reptiles. Nowadays the Tashkent Zoo occupies 21.5 hectares and has 373 animal species. 12 animal displays and the zoo are open to the public. The new territory has animal cages, including big wintering quarters.

Keywords:
Innovative Motivation Methods of Staff At Small and Private Business Enterprises
Authors: Maripova Shahlo Akramovna  
Published: March 2024

.This article discusses one of the crucial challenges for small businesses today- issue of motivation at staff members which in the long run can lead either to prosperity of business or to the failure of it. The aim of this work is to study the reasons and consequences of this phenomenon for small business and private enterprises. During our research we comprehensively studied the works of world expertise on the raised issue, different research methods were used such as abstraction, induction and deduction, methods of observation, logical and structural analysis, grouping, mutual and comparative comparison. Various concepts of work motivation were analysed, concepts proposed by A.Maslow, K.Alderfer, McCelland, F.Herzberg were studied in detail taking into account the specific of human resource management at small business companies. In conclusion, several recommendations were given for small businesses’ managers regarding creating favourable conditions for staff motivation at workplace.
“Estar Tranquilo”: Using a Life-course Approach to Explore Perceptions of Well-being among Older Adults in Curicó, Chile
Authors: Salazar-Norambuena Carola 
Published: March 2024

This study assesses perceptions of well-being between two groups of older adults in Curicó, Chile. One group (n=12) were residents of a long-term care center (known as ELEAM), while another group (n=13) were members of two clubs for older adults – Estrellitas del Vaticano (Vatican’s Little Stars) and Club Campo Lindo (Beautiful Countryside) – who lived in their own homes. Data collection consisted of life-story narratives to explore differences in how older adults in different living situations – long-term residential care vs. independent living – define and perceive what it means to be well in older age. Both groups were paired according to the variables of age, educational level, socioeconomic status, and physical status. In this article, I explore how both groups expressed their desire to estar tranquilo or “be peaceful” in their older age; however, each group achieved this state in different ways. ELEAM residents focused on fostering good relationships with fellow residents and maintaining their autonomy. In contrast, club members focused on practicing their religion, maintaining family relationships, and engaging in activities. Although participants shared similar backgrounds and lived through the same historical events (i.e., military dictatorship), their current situations impacted their perceptions of well-being. For individuals to achieve their desired level of well-bing or to estar tranquilo required that they adapt to different living arrangements: club members had to adapt to living without their children, and ELEAM residents to living in an institution.
L’adaptation comme incorporation
Authors: Malcor Adrien 
Published: March 2024

Avec Crimes of the Future en 2022, David Cronenberg revient à sa science-fiction : le film est basé sur un scénario original écrit par le cinéaste dans la foulée d’eXistenZ. Mais vingt ans avant sa sortie, ce film (intitulé Painkillers à l'époque) avait parfois été annoncé dans la presse comme une adaptation du « Manifeste de l’Art charnel » de l’artiste française ORLAN. On peut montrer que Cronenberg a bel et bien pris au sérieux les idées d’ORLAN sur l’« athéisme » de la performance chirurgicale (médicalement assistée), et qu’il leur a fait subir la pression de ses lectures philosophiques et de ses intérêts biologiques. Qu’est-ce que le « syndrome d’évolution accélérée » dont souffre l’artiste Saul Tenser ? Comment l’enfant Brecken digère-t-il le plastique ? L’humanité de Crimes of the Future semble à nouveau aux prises avec l’évolution darwinienne, mais le film raconte aussi bien l’affrontement des contre-hypothèses. L’adaptation de la théorie rencontre ici les théories de l’adaptation. Si Crimes of the Future est un film sur l’adaptation, c’est d’abord qu’il met en scène le débat Nietzsche versus Darwin à l’aune des problèmes artistiques et scientifiques contemporains.
What’s Moral Distress Got to Do With It? How to Avoid Burnout and Optimize Patient Care
Authors: He Bowen , Finkelstein Claudia A , Symonds Lynn , Uy Natalie F , Linden Hannah M 
Published: March 2024

Burnout, estimated to affect between 40-80% of healthcare professionals, is a complex issue encompassing emotional exhaustion, depersonalization, and a decreased sense of personal accomplishment. The Stanford Model of Professional Fulfillment considers both individual and system-level factors with three main elements of efficiency of practice, personal resilience, and culture of wellness. Dr. Finkelstein’s alternate model for burnout reimagines the Stanford Model with three main factors contributing to burnout: inevitable suffering, moral distress, and “extra junk.” In Dr. Finkelstein’s alternate model, inevitable suffering arises from the emotional toll of providing patient care. While interventions like coaching, therapy, and mindfulness are beneficial, they must be offered genuinely, not as profit-driven schemes. “Extra junk” refers to administrative burdens that take away from patient care. Some initiatives aim to alleviate these burdens, but their effectiveness needs critical evaluation. Finally, moral distress occurs when external constraints hinder an individual’s ethical actions. Burnout affects not just individual professionals but also the entire healthcare system, leading to early retirements, lower quality care, and worsening health outcomes. Recognizing this, the US Surgeon General has outlined an approach to address burnout that requires cultural changes at all levels of the healthcare ecosystem. Healthcare professionals are resilient, and part of the solution lies in individual recognition of burnout, work-life balance, and finding joy in work. However, larger cultural shifts towards justice and equity, both within healthcare and broader society, are needed. This includes prioritizing workforce diversity, humane sick and maternity leave policies, and reducing unnecessary administrative burdens. Academic institutions also have a role in promoting mentorship, recognizing the contributions of underrepresented groups, and supporting burnout research. Addressing burnout effectively requires a comprehensive approach that considers individual and system-level factors, advocating for systemic reforms, and prioritizing justice and equity within the healthcare ecosystem.