bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression profile analysis and the role of miRNA in breast adenocarcinoma
Authors: Zhang Ming-Yang , Huang Yi-Min , Lv Xiang , Yang Xingxia , Shen Si-Jia , Wang Jian-Guo , Zhu Juan-Yin 
Published: March 2024

Abstract
To search for hub microRNAs (miRNAs) that might serve as biomarkers for breast cancer (BC), we conducted out comprehensive analysis of data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and whole transcriptome profiling (WT). For overall sample analysis, we found 3 differently expressed miRNA in BC tissues compared to para-carcinoma tissues (PT). Subtype analysis showed that 19, 36 and 19 miRNAs were respectively specific differently expressed in early-stage breast cancer (EBC), advanced stage breast cancer (ABC) and Triple-negative breast cancer (TNBC) compared to PT. Multivariate Cox regression analysis showed that hsa-miR-342-3p and hsa-miR-7705 were independent prognostic factors for overall BC and EBC, respectively. And we found hsa-miR-181b-5p, hsa-miR-3200-3p and hsa-miR-4789-3p were all independent prognostic factors for ABC. Moreover, Kaplan-Meier survival analysis showed that hsa-miR-160b-5p significantly affected the survival of patients in ABC. GSEA demonstrated that tumor related KEGG items (such as cell cycle, ERBB signaling pathway, Wnt signaling pathway, etc.) were differentially enriched in BC. The results of qPCR showed that the expression status of hsa-miR-342-3p, hsa-miR-7705 hsa-miR-160b-5p and hsa-miR-3200-3p were consistent with the results of comprehensive analysis. Finally, this study revealed hsa-miR-342-3p, hsa-miR-7705, hsa-miR-160b-5p and hsa-miR-3200-3p can be used as prognostic biomarkers for BC.
Cyberbullying and mental distress among adolescents in secondary school: Tunisian cross sectional study
Authors: Touhemi Donia Ben , Maryam Chaabane , Khaoula Khemakhem , khadija Chiha , Hela Ayadi , Yousr Moalla 
Published: March 2024

Abstract
Purpose: Ours study aimed to describe the characteristics of adolescents who are victims of cyberbullying and to evaluate the psychological state of these victims.
Methods: This is a cross-sectional, descriptive, and analytical study conducted with a representative sample of adolescents attending 6 schools in the Sfax region during the month of February 2022. The pre-established form containing socio-demographic and family information was used. Cyberbullying was assessed using the "Cyber-Harassment Student Survey". Mental distress was evaluated using the Depression Anxiety Stress Scales (DASS-21), validated in Arabic.
Results: Data was collected data from 396 adolescents, of which 54.8% were female. The average age of participants was 16.65 years.
Cyberbullying was reported by 47% of the surveyed adolescents.
Factors associated with cyberbullying in these adolescents included residing in urban areas (p = 0.017), experiencing relational problems with parents (p = 0.001) and siblings (p = 0.002), the presence of behavioral problems in school (p = 0.009), and low academic performance (p = 0.000)
Among cyberbullying victims, 41.3% reported moderate to severe depressive symptoms; 47.8% had moderate to severe anxiety levels, and 29.5% had moderate to severe stress levels. Cyberbullying was strongly correlated with depression (p < 0.0001), anxiety (p = 0.00), and stress (p = 0.00).
Conclusion: The results of this study indicate that cyberbullying is widespread within schools and has negative consequences on the mental health of young individuals. Recognizing this prevalence is essential and calls for a prevention strategy against cyber-related issues.
Do residents in proximity to blue spaces exhibit lower emotion-related impulsivity? The mediating role of perceived crowdedness
Authors: Liu Jia , Liu Siyi , Meng Jiahui , Meng Yilin , Yang Zhihui 
Published: March 2024

Abstract
Background
Emotion-related impulsivity (ERI) is a significant predisposing factor for various mental health issues and is influenced by individuals' immediate environment. Previous research has largely focused on mitigating ERI through individual-level interventions without extensively considering the role of the external environment. This study explores the impact of passive blue space exposure (PBSE) on ERI, considering both subjective and objective measures of PBSE and investigating the mediating role of perceived crowdedness.
Methods
Two studies were conducted using online platforms to collect data from Chinese residents. Study 1 (n = 369) examined the predictive effect of objective PBSE, as assessed by the normalized difference water index (NDWI), on ERI. Study 2 (n = 374) focused on subjective PBSE and the mediating effect of perceived crowdedness on ERI. Descriptive statistics, correlational analyses, and path analyses were employed to evaluate the relationships between PBSE, perceived crowdedness, and ERI.
Results
Study 1 demonstrated a negative correlation between objective PBSE and ERI, with marginal significance in predictive analysis after controlling for covariates. Study 2 revealed that subjective PBSE was significantly negatively associated with ERI, and perceived crowdedness significantly mediated this relationship. Subjective PBSE reduced perceived crowdedness, which in turn decreased ERI, accounting for 20% of the total effect. The findings suggest that PBSE, both objective and subjective, may serve as a protective factor against ERI.
Conclusions
This research highlights the negative association between PBSE and ERI, extending the understanding of environmental influences on impulsive behavior. It emphasizes the potential of utilizing blue spaces in urban planning and individual exposure to alleviate impulsivity. The study also sheds light on the importance of considering both subjective and objective environmental factors in psychological research and interventions. Future studies should consider a comprehensive approach to measuring PBSE and explore causal relationships through experimental designs.
A Trust-region Framework for Iteration Solution of the Direct INDSCAL Problem in Metric Multidimensional Scaling
Authors: Zhou Xue-lin L. , Li Chao-qian 
Published: March 2024

Abstract

The well-known INdividual Differences SCALing (INDSCAL) model is intended for the simultaneous metric multidimensional scaling (MDS) of several doubly centered matrices of squared dissimilarities. An alternative approach, called for short DINDSCAL (direct INDSCAL), is proposed for analyzing directly the input matrices of squared dissimilarities. In the present work, the problem of fitting the DINDSCAL model to the data is formulated as a Riemannian optimization problem on a product matrix manifold comprised of the Stiefel sub-manifold of zero-sum matrices and non-negative diagonal matrices. A practical algorithm, based on the generic Riemannian trust-region method by Absil et al., is presented to address the underlying problem, which is characterized by global convergence and local superlinear convergence rate. Numerical experiments are conducted to illustrate the efficiency of the proposed method. Furthermore, comparisons with the existing projected gradient approach and some classical methods in the MATLAB toolbox Manopt are also provided to demonstrate the merits of the proposed approach.
Mathematics subject classification: 15A24; 15A57; 65F10; 65F30
The Utilization of Psychosocial Oncology Services by Oral Cancer Patients According to their Language Profile in the Montreal Area: a Real-Word Observational Study Protocol
Authors: Janati Amal Idrissi , Gigliotti Jordan , Sanders Justin , Makhoul Nicholas , Emami Elham , Martel Marc O. , Gosselin Nathalie , Cailhol Lionel , Brown-Johnson Anita , Karra Nour , Ramanakumar Agnihotram V. 
Published: March 2024

Abstract

Background
Many oral cancer patients experience psychosocial distress during their care trajectory. In recent years, psychosocial oncology services have been established in numerous hospitals to support cancer patients with emotional, psychological, or social needs. The use of psychosocial oncology services by oral cancer patients has not been documented, which hinders monitoring and continuous improvement of care. In Quebec, the shortage of care personnel, persistent barriers to screening for distress, and the stigma of using mental health services influence the use of psychosocial oncology services in oral oncology. This impact is particularly highlighted among the English-speaking minority, where challenges in accessing health and mental health services have been reported. Thus, this study aims to generate surveillance data on the use of psychosocial oncology services by oral cancer patients and survivors, according to their official language status in Quebec.
Methods
We will conduct a retrospective cross-sectional study based on real-world data from oral cancer patients who are followed at one of Montreal's major hospital centers. In addition to sociodemographic and clinical data, French-speaking and English-speaking patients will be compared regarding the referral rate to the psychosocial oncology department, the delay and response rate to these requests, and the type of psychosocial oncology services received. Analyses will be conducted to explore factors related to possible differences in the use of psychosocial oncological services between French- and English-speaking patients.
Discussion
Communicating our data to healthcare providers and decision-makers will allow them to review their policies and strategies to promote comprehensive care for oral oncology patients while ensuring equity of access to services between the linguistic minority and majority.
Efficacy and prognosis of surgical treatment for burning hands syndrome patients
Authors: Liu Yapu , Su Yuanyuan , Wang Songmao , Gao Lifeng , Zheng Xiaochen , Ge Hailong , Hou Xiuwei , Wu Guangliang 
Published: March 2024

Abstract
Purpose: Few reports have discussed surgical treatment of patients with burning hands syndrome, a mild variant of traumatic central spinal cord syndrome (TCCS). In this report, we characterized the role of surgical treatment for patients with burning hands syndrome.
Methods: A total of 32 cases from August 2013 to August 2018 met the inclusion criteria, including 26 males and 6 females aged 55.7±10.8 years. All patients complained of burning, numbness, and tingling in hands after cervical hyperextension injury, and no sensory or motor dysfunction of the lower limbs. The graded redefined assessment of strength, sensibility, and prehension (GRASSP) scoring system was used to evaluate upper limb neurological function preoperatively, 1 week after surgery, and at the last follow-up.
Results: All patients were followed up for more than 24 months, with an average follow-up of 50.4±18.4 months. The nerve function of the upper limbs had recovered significantly after 1 week and at the last follow-up. The percentage of patients showing improvement at 1 week after surgery was 44.7±2.6% for dorsal sensory function, 44.8±2.7% for palmar sensory function, 46.4±3.4% for strength, 44.3±4.1% for prehension ability, and 48.7±3.6% for prehension performance. The percentage of patients showing improvement at the last follow-up period was 90.2±2.5% for dorsal sensory function, 89.0±2.5% for palmar sensory function, 93.3±2.5% for strength, 91.3±2.8% for prehension ability, and 91.4±2.5% for prehension performance.
Conclusions: Our results show that surgical decompression and internal fixation in patients with burning hands syndrome can achieve good neurological recovery.
Open Innovation and Regulatory Challenges in New Modality Development: The Pivotal Role of CDMOs in Advancing Antibody Drugs
Authors: Yoshiura Hiromu , Kawata Yayoi , Sengoku Shintaro 
Published: March 2024

Abstract

Background Ensuring regulatory-compliant manufacturing capability is an essential challenge for new treatment modalities, but its internalisation is not easy for pharmaceutical companies, especially start-ups. This study examines the functions and requirements of contracted development and manufacturing organisations (CDMOs) using the development process of antibody medicines as a case study.
Methods Utilizing PubMed, Cortellis and Patent Integration databases, this study delves into publication and contractual trends in monoclonal antibody drugs (mAbs) development, alongside an analysis of patent filings by CDMOs, offering a comprehensive overview of the evolving landscape in mAbs innovation.
Results In the early stages of mAbs development, dedicated bio firms (DBFs) led R&D with superior drug discovery technology but lacked manufacturing capability, which was complemented by CDMOs. This collaboration was an opportunity for CDMOs to expand their capabilities beyond manufacturing technology into antibody drug candidate discovery and structural optimisation technology. From mid-development onwards, it established a technology platform based on these capabilities and developed and established partnerships with existing pharmaceutical companies, including mega pharma.
Conclusions The impact of institutions and regulations on the innovation process was assessed during this development process. These findings are expected to provide valuable insights into the innovation system for new modalities.
Comparison of Subjective and Objective Visual Quality of Two Main Types of Refractive Surgeries in Early Postoperative Stage
Authors: Zou Zongyin , Li Hui , He Runzhang , Nong Yating , Zhou Sheng , Yang Jing 
Published: March 2024

Abstract

Purpose:
To explore subjective and objective visual quality of patients who underwent laser refractive surgery and ICL implantation in early postoperative stage after adjusting the imbalance of the baseline characteristics.
Methods:
This retrospective study included 58eyes with myopia and myopic astigmatism who underwent ICL V4c implantation or laser refractive surgery (including SMILE and FS-LASIK) in our hospital from July 2022 to December 2021. Objective visual quality mainly including higher-order aberrations (HOAs) were measured using an OPD-Scan III aberrometer (Nidek Co., Ltd., Gamagori, Japan) preoperatively and 1 week postoperatively. The subjective visual quality was obtained through the Quality of Vision (QoV) questionnaire. The propensity score inverse probability of treatment weighting (PS-IPTW) was used to balance the baseline characteristics.
Results:
After IPTW, the confounding factors with statistical significance between laser refractive surgery group and ICL implantation group. Before IPTW, the objective visual quality of laser refractive surgery was better than ICL implantation. However, after IPTW, only spherical aberration(p＝0.023) is statistically different between two groups. The patients who underwent laser refractive surgery reported better subjective visual quality in frequency(p＝0.020), severity(p＝0.043) and bothersome(p＝0.002). But two groups showed no significant difference after IPTW.
Conclusion:
The subjective and objective visual quality of patients who underwent laser refractive surgery and ICL implantation are relatively similar in early postoperative stage. The better subjective and objective visual quality in laser refractive surgery than ICL implantation could be influenced by imbalanced baseline characteristics.
Identification of plasma exosomal lncRNA as a biomarker for early diagnosis of gastric cancer
Authors: wei ye , Hu Xuming , Yuan Shuai , Zhao Yue , Zhu Chunhui , Guo Mingzhou , Cui Hengmi 
Published: March 2024

Abstract
Background,
there were about 1,090,000 gastric cancer(GC) cases in 2020 in China. The incidence and mortality rates ranked the fifth and third among all kinds of cancers in China. Early diagnosis plays an important role in the treatment and prognosis of gastric cancer. In recent years, noninvasive diagnosis, especially plasma exosome lncRNAs, has become a promissing biomarkers with high specificity and sensitivity for early diagnosis of cancers.
Methods, in this study, the exosomes in the plasma of patients with early gastric cancer were isolated by a commercial kit. After identified by electron microscopy observation, particle size analysis and western-blot verification, the lncRNAs in the exosomes were extracted. The lncRNAs differentially expressed in the plasma exosomes of patients with gastric cancer were analysized by high-throughput RNA sequencing(RNA-Seq). The differentially expressed lncRNAs were verified by RT-qPCR in 93 patients with early gastric cancer and 49 normal controls.
Results, Electron microscopy, particle size analysis and western blot showed that exosomes were successfully isolated from plasma. RNA-Seq results show that 76 lncRNAs were up-regulated and 260 lncRNAs were down regulated in plasma exosomes of early gastric cancer patients compared with normal controls. RT-qPCR analysis indicated that a total of 6 lncRNAs were significantly and differentially expressed in gastric cancer patients compared to normal controls, with 2 (lncmstrg. 1319590,Lncmstrg. 2312697) highly expressed and 4 lowly expressed (lncmstr-g.1004024.1, lncmstrg. 2441832.8, lncmstrg. 315376.1, lncmstrg. 907985.2,)(p < 0.05). The survival curve analysis indicated that lncmstrg.2441832.8 and lncmstrg.2312697 had higher sensitivity and specificity for the diagnosis of gastric cancer, respectively and AUC curve areas were 0.6211 and 0.631, p < 0.05, respectively, which were greater than the traditional clinical detection indexes CEA (0.61) and AFP (0.57). When combined lncmstrg.2441832.8 and lncmstrg.2312697 in gastric cancer diagnosis, AUC curve area reached 0.73, which was greater than CA199 (0.71).
Conclusion, lncmstrg.2441832.8 and lncmstrg.2312697 may be a potential and promissing biomarkers for early diagnosis of gastric cancer.
A novel structure of vehicle motion cueing algorithm for a pneumatic motion simulation platform
Authors: Liu Chao , Li Li , Zhao Ling 
Published: March 2024

Abstract

In this paper, a novel structure of motion cueing algorithm (MCA) is proposed to simulate translational accelerations and angular velocities of vehicles on a pneumatic motion simulation platform (PMSP). The designed MCA includes nonlinear scaling algorithm, linear quadraticregulator (LQR), low pass filter and data fusion algorithm.Taking into account absolute sensory thresholds of human vestibular organ, the nonlinear scaling algorithm is designed to scale the translational accelerations and angular velocities of vehicles for ensuring the outputs of the MCA are inangular displacement ranges of the PMSP. According to the model of otolith organ and semicirular canal, the LQR ispresented to constrain the perception errors between the vehicles and PMSP. The data fusion algorithm is proposed to obtain desired angular displacement of the PMSP from the outputs of the nonlinear scaling algorithm for reducing perception errors. Considering the ranges of deflection angleand angular velocity on the PMSP, perception errors and absolute sensory thresholds, gains of the MCA are optimized by genetic algorithm. Note that the designed MCA can notonly be applied to the PMSP, but also be extended to the classical 6-degree-of-freedom platform for improving simulation performance. Finally, the effectiveness of the proposed algorithm is verified by real experiment using an active disturbance rejection controller.
A systematic computational DFT study for the phosphorus based drug-carrier mechanism for heparin a life-saving anticoagulant for cardiovascular diseases
Authors: Ahmad A. , Abahussain A. A.M , Nazir M. H. , Zaidi S. Z.J. 
Published: March 2024

Abstract

Cardiovascular diseases (CVDs) are the major cause of global morbidity and mortality, representing a substantial burden on global healthcare. Thrombotic events serve as major determinants of patient outcomes. Heparin, an anticoagulant drug, is crucial in treating thrombotic disorders. Its clinical utility is limited due to the challenges related to targeted delivery. In this study, we employed computational material modeling techniques using DFT calculations to investigate the potential of black phosphorus as drug carrier for heparin drug delivery. Thermodynamic favorability of interaction between drug and carrier is investigated by adsorption energies calculations. Molecular orbital analysis reveals the electron transfer process and potential reactivity of drug, carrier and their complexes, important for understanding the drug delivery mechanism. The properties such as chemical potential, chemical hardness, chemical softness and global electrophilicity index are computed to study the stability of drug delivery complexes. Weak intermolecular interactions between heparin and black phosphorus are highlighted by non-covalent interaction (NCI) analysis. UV-vis analysis was employed to generate UV-vis spectra of drug delivery complexes. These spectra reveal the potential photochemical properties of complexes, crucial for triggering drug delivery mechanism. This study presents the valuable insights into the therapeutic potential of black phosphorus as drug carrier for heparin drug delivery to treat cardiovascular diseases such as thrombotic events.
The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation
Authors: Vestergaard Mark Bitsch , Bakhtiari Aftab , Osler Merete , Mortensen Erik Lykke , Lindberg Ulrich , Law Ian , Lauritzen Martin , Benedek Krisztina , Larsson Henrik Bo Wiberg 
Published: March 2024

Abstract

Background
Accumulation of β-amyloid (Aβ) in the brain is a hallmark of Alzheimer’s Disease (AD). Cerebral deposition of Aβ initiates deteriorating pathways which eventually can lead to AD. However, the exact mechanisms are not known. A possible pathway could be that Aβ affects the cerebral vessels, causing inadequate cerebrovascular function. In the present study, we examined if Aβ accumulation is associated with a reduced cerebral blood flow response (CBF) to neuronal activation by visual stimulation (DCBFVis.Act) in cognitively normal subjects from the Metropolit Danish Male Birth Cohort.
Methods
64 subjects participated in the present study. DCBFVis.Act was measured using arterial spin labelling (ASL) combined with blood-oxygen-level-dependent (BOLD) MRI. Neuronal activation was obtained by visual stimulation by a flickering checkerboard presented on a screen in the MRI-scanner. Brain Aβ accumulation and cerebral glucose metabolism were assessed by PET imaging using the radiotracers [11C]Pittsburgh Compound-B (PiB) and [18F]Fluorodeoxyglucose (FDG), respectively. Cortical thickness was measured from structural MRI.
Results
DCBFVis.Act correlated negatively (\(\beta\) = -32.1 [95% confidence interval (CI): -60.2 ; -4.1], r = -0.30, p = 0.025) with PiB standardized uptake value ratio (SUVr) in the brain regions activated by visual stimulation. DCBFVis.Act did not correlate with FDG SUVr (\(\beta\) = 1.9 [CI: -23.8 ; 27.6], r = 0.02, p = 0.88) or cortical thickness (\(\beta\) = 10.3 [CI: -8.4 ; 29.0], r = 0.15, p = 0.27) in the activated brain regions. Resting CBF did not correlate with PiB SUVr neither in the regions activated by visual stimulation (\(\beta\) = -17.8 [CI:-71.9 ; 36.2], r = 0.09, p = 0.51) nor in the remaining cortex (\(\beta\) = 5.2 [CI:-3.9 ; 14.2], r = 0.15, p = 0.26).
Conclusion
We found a correlation between high PiB SUVr and reduced CBF response to neuronal activation, indicating a link between Aβ accumulation and impaired cerebrovascular function. The impairment was not associated with cortical thinning or hypometabolism, suggesting that Aβ accumulation affecting brain vessel function could be a very early pathology leading to neurodegenerative disease.