bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Cercariform” cells: A clue to the cytodiagnosis of transitional cell origin of metastatic neoplasms?
Authors: Powers Celeste N. , Elbadawi Ahmad 
Published: February 2007

AbstractThe “cercariform” cell is described as a distinct cytomorphologic clue that may be helpful in the diagnosis of metastatic transitional cell neoplasms, particularly low grade. This cell has a nucleated globular body and a cytoplasmic process with a nontapering, flattened, bulbous or fishtail‐like end. The cercariform cell corresponds to intermediate cells in histologic and ultrastructural preparations of normal urothelium. The cercariform appearance is the result of pseudostratification of both normal and low‐grade neoplastic urothelium. The unique features of cercariform cells make them readily distinguishable from neoplastic squamous cells as well as spindle cells of mesenchymal origin. © 1995 Wiley‐Liss, Inc.
Neovaginal cytology after total pelvic exenteration for gynecological malignancies
Authors: Selvaggi Suzanne M. , Haefner Hope K. , Lelle Ralph J. , Pearl Michael L. , Roberts James A. 
Published: February 2007

AbstractVaginal reconstruction has become an established method to re‐store sexual function in women who have undergone ultraradical surgery and/or irradiation for the treatment of gynecologic malignancies. Cytologic evaluation of the neovagina serves a major role in the detection of recurrent disease. The purpose of this retrospective 6‐yr study (January 1987–December 1993) was to evaluate the cytologic features of vaginal smear specimens from neovaginas constructed utilizing split‐thickness skin grafts. Thirty‐four vaginal smears were obtained at regular intervals from nine women (mean age: 51 yr) who underwent total pelvic exenteration with vaginal reconstruction for recurrent malignancies of the vagina and the cervix. Anucleated, keratinizing squames were a constant finding in each smear. Over a 4‐mo‐6‐yr postoperative period, superficial and intermediate squamous cells were present in the majority of the smears and the maturation index showed a shift to the right. In two cases, a squamous cell carcinoma of the cervix recurred within the neovagina. Knowledge of the cytologic features associated with neovaginas is important in order to distinguish normal changes from neoplastic lesions. © 1995 Wiley‐Liss, Inc.
Cytopathology of undifferentiated (embryonal) sarcoma of the liver
Authors: Sola‐Pérez Joaquín , Pérez‐Guillermo Miguel , Giménez‐Bascuñana Alberto , Garre‐Sánchez Carmen 
Published: February 2007

AbstractWe have studied one undifferentiated (embryonal) sarcoma of the liver (USL) by fine‐needle aspiration cytology (FNAC) and have correlated the cytologic findings with those seen in the histologic sections.The main cytologic and immunocytochemical features were: cellular aspirates, mesenchymal clusters, disparity in individual cell size (small round cells, and multinucleated giant cells, sometimes bizarre), absence of biliary pigment, AFP‐negative and vimentin‐negative tumor cells, AFP‐negative and PAS‐positive hyaline globules, and apoptotic cells.Only immunostaining for alpha‐1‐antitrypsin, alpha‐1‐anti‐chymotrypsin, and carcinoembryonic antigen were positive in tumor cells in histologic sections.The differential diagnosis should be carried out with rhabdomyosarcomas, hepatoblastomas, malignant fibrous histiocytomas, and poorly differentiated hepatocarcinomas.We think that the cytologic features observed in this case, evaluated both in the appropriate clinical context and in the light of the laboratory findings, may permit the correct diagnosis of this infrequent liver tumor. Nevertheless, more cases need to be studied to assess the reliability of our findings. © 1995 Wiley‐Liss, Inc.
Paracoccidioidomycosis: Diagnosis by fine‐needle aspiration cytology
Authors: Drut Ricardo 
Published: February 2007

AbstractA 4‐yr‐old girl presented with constitutional symptoms, abdominal swelling, ascites, and cervical lymphadenopathy. Fine‐needle aspirate smears of a cervical lymph node revealed numerous round yeasts, many of them with several peripheral buds fitting the pattern of Paracoccidiodes brasilensis. This appears to be the first case in which the diagnosis of this deep mycosis was achieved by FNAC. The procedure may prove useful for rapid diagnosis in cases like the present one which represents the so‐called acute disseminated form which affects mainly children and immunosupressed patients and can be rapidly fatal. © 1995 Wiley‐Liss, Inc.
Epithelioid hemangioendothelioma of the lung: Pleural effusion cytology, ultrastructure, and brief literature review
Authors: Buggage Ronald R. , Soudi Nael , Olson Jean L. , Busseniers Anne E. 
Published: February 2007

AbstractEpithelioid hemangioendothelioma (EHE) of the lung is a low‐grade malignant tumor of vascular origin initially described under the name intravascular bronchioloalveolar tumor (IVBAT). We present a case of a 44‐yr‐old Caucasian female with severe radiating back pain, shortness of breath, recurrent malignant pleural effusions, and a negative malignancy workup. Cytopathologic examination of the four pleural fluid specimens revealed large undifferentiated plasmacytoid malignant cells with abundant pink and finely granular cytoplasm, round nuclei, and prominent nucleoli. The differential diagnosis based on the cytologic findings included hepatocellular, adrenal, and renal carcinomas, melanoma, mesothelioma, and neuroendocrine tumors. Electron microscopy performed on a pleural fluid specimen and subsequent histologic examination of pleural and lung biopsies established the diagnosis of EHE. © 1995 Wiley‐Liss, Inc.
Cytologic diagnosis of cat scratch disease (CSD) by fine‐needle aspiration
Authors: Donnelly Amber , Hendricks Gary , Martens Susan , Strovers Cindy , Wiemerslage Sara , Thomas Patricia A. 
Published: February 2007

AbstractCat scratch disease (CSD) is usually a benign, self‐limited lymphadenitis, characterized by suppurative granulomas. It can, however, produce a wide spectrum of clinical symptoms and cytologic changes and be the source of diagnostic dilemmas. Identification of pleomorphic bacilli (PB) with silver impregnation stains aids in the diagnosis, but this has not been well documented in cytologic preparations or in cases without the classic morphologic changes. We reviewed 13 aspirations from eight patients (aged 13–36 yr) occurring over a 15 mo time period, all clinically or cytologically suspicious for CSD. Sites included: axilla (6), parotid (3), epitrochlear (1), neck (1), submental (1), and intraclavicular (1) nodes. Neoplasia was initially suspected clinically in 38% of the cases. All but two patients had cat exposure on subsequent interview. The cytologic differential included bacterial abscess and lymphoproliferative disorders in 31%. Neither granulomas nor suppurative inflammation were seen in all cases. Changes included: granulomas (77%), PMNs (62%), dispersed epithelioid histiocytes (46%), and suppurative granulomas (38%). A modified silver stain (Modified Steiner, Sigma Diagnostics, St. Louis, MO) was performed on all specimens. Silver positive organisms were seen in 69% of cases and were not limited to those preparations with suppurative granulomas. Fine‐needle aspiration biopsy (FNAB) is an effective method for diagnosing CSD despite its heterogeneous appearance; and, when combined with clinical information and silver staining, may obviate the need for excision. © 1995 Wiley‐Liss, Inc.
Value of image guided fine‐needle aspiration cytology in the diagnosis of pancreatic malignancies
Authors: Gupta Raj K. 
Published: February 2007

AbstractIn the period between 1981–1993, 93 image guided fine‐needle aspiration cytology (FNAC) of the pancreas were performed on 63 patients suspected of having a pancreatic carcinoma. From these, 42 patients were subsequently confirmed to have had a pancreatic malignancy by a tissue biopsy. However, FNAC was positive in 29 cases (69.04%) while seven cases (16.66%) were classified as suspicious. In six cases of malignancy (14.28%), cytologically diagnostic material was not sampled using FNAC; hence it was considered that FNAC evaluation gave false negative results in these cases. As a result of this study it was felt that while a cautious approach is necessary in view of certain false negative results, on the whole FNAC was a valuable investigation in the diagnosis of pancreatic carcinoma with no serious complications in this series. Also, FNAC under imaging assistance is a fairly reliable and safe procedure and the false negative results may be reduced by repeat aspirations especially in cases when insufficient diagnostic material is obtained in a patient clinically suspected of a pancreatic carcinoma. © 1995 Wiley‐Liss, Inc.
Serosal balls detected immunocytochemically in peritoneal lavage obtained during surgery
Authors: Sasaki Masaomi , Wakasa Kenichi , Sakurai Masami , Iwa Nobuzo 
Published: February 2007

AbstractUsing the immunoperoxidase technique, we studied “serosal balls,” which have features resembling those of cells from primary and metastatic tumors, and may thus complicate cytodiagnosis. Serosal balls were detected in 32 (18%) of 174 peritoneal washings. The balls consisted of oval clusters of cells in solid masses surrounded by flattened cells. The interior of the serosal balls was stained green with Papanicolaou method, showing the presence of homogeneous amorphous material, sometimes stained in a filamentous pattern. Almost all serosal balls were stained immunocytochemically for both keratin and vimentin. The interior was stained with antibodies against collagen types I and III. Therefore, these balls were fragments of serous membrane, and contained fibrous tissue and mesothelial cells. © 1995 Wiley‐Liss, Inc.
p53 protein expression in fine‐needle aspirates of breast cancer: An immunocytochemical assay for identifying high‐grade ductal carcinomas
Authors: Colecchia Maurizio , Frigo Barbara , Zucchi Alberto , Leopardi Orazio 
Published: February 2007

AbstractThe expression of the p53 gene product was investigated immunocytochemically in a series of 51 fine‐needle aspiration (FNA) samples of breast carcinomas. Results were compared with those obtained by immunocytochemistry on paraffin embedded tissue sections of the corresponding surgical specimens. Cytological samples showed a variable degree of p53 immunoreactivity in 14 tumors (27.6%), all of ductal type, while p53 immunoreactive tumor cells were present in tissue sections from 15 carcinomas (29.4%). The only discordant case was a signet‐ring cell carcinoma.Abnormal p53 expression was significantly associated with high nuclear grade in ductal carcinomas. No association was seen with tumor size, lymph node status, and age of the patient. Detection of p53 altered expression in FNA samples of breast carcinoma may play a role in the assessment of tumoral grading and is predictive of p53 immunoreactivity in histological specimens. © 1995 Wiley‐Liss, Inc.
Aspiration biopsy cytology of intranodal myofibroblastoma: Case report with immunocytochemical analysis
Authors: Dei Tos Angelo P. , Libera Duilio Della , Bittesini Lucia 
Published: February 2007

AbstractIntranodal myofibroblastoma (IM) is a recently delineated clinicopathologic entity represented by a myofibroblastic proliferation of the lymph node. It usually occurs at the groin and presents clinically as a single enlarged lymph node. Its clinical behavior is entirely benign and local excision is curative. The authors herein report a case of IM diagnosed by aspiration biopsy cytology (ABC). The main diagnostic clues to the cytologic diagnosis of this entity as well as the differential diagnosis are presented. © 1995 Wiley‐Liss, Inc.
Primary hepatic lymphoma: Report of two cases diagnosed by fine‐needle aspiration
Authors: Rappaport Karen M. , Digiuseppe Joseph A. , Busseniers Anne E. 
Published: February 2007

AbstractPrimary hepatic lymphoma (PHL) is a rare disease which tends to progress slowly in the absence of other disorders and remains confined to the liver until late in its course. We report two patients with PHL diagnosed by fine‐needle aspiration (FNA). Histopathologically, PHL can be misdiagnosed as poorly differentiated carcinoma or hepatocellular carcinoma. On FNA, cellular smears with artifactual grouping of malignant cells may result in similar errors. Since PHL has an excellent prognosis and is not usually the working diagnosis in patients who present with a solitary liver mass, a high index of suspicion is necessary to make the diagnosis. We report two cases of PHL in which the diagnosis of lymphoma was rendered on FNA. In one patient, who carried a clinical diagnosis of cavernous hemangioma for 18 mo, FNA showed large‐cell lymphoma, B‐cell type. Subsequent extensive workup did not reveal extrahepatic disese. The other patient, followed for sclerosing cholangitis, was clinically thought to have developed cholangiocarcinoma. FNA revealed high grade lymphoma, B‐cell type. We present the clinical, radiologic, and pathologic findings and differential diagnoses of PHL as well as the various clinical settings in which PHL has been described. © 1995 Wiley‐Liss, Inc.
Exfoliative cytology of adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix
Authors: Vogelsang Philip J. , Nguyen Gia‐Khanh , Honoré Louis H. 
Published: February 2007

AbstractCervical scraping smears from two cases of histologically confirmed adenoma malignum of the uterine cervix were reviewed. In one case, several irregular sheets of benign‐appearing glandular cells with slightly enlarged nuclei, conspicuous nucleoli, and clear cytoplasm were found. In the other case, in addition to sheets of benign‐appearing glandular cells, there were clustered malignant glandular cells with prominent nucleoli. The sheets of benign‐appearing glandular cells in both cases displayed wispy cytoplasmic extensions or “tails.” Cytologic differential diagnosis with other glandular lesions of the cervix such as clear cell carcinoma, microglandular hyperplasia, diffuse laminar glandular hyperplasia, tubal metaplasia, and well‐differentiated invasive or in situ adenocarcinoma is briefly discussed. © 1995 Wiley‐Liss, Inc.
Unusual small bone metastases from epithelial malignancies: Diagnosis by fine‐needle aspiration cytology with histologic confirmation
Authors: Singh Harsharan K. , Silverman Jan F. , Ballance William A. , Park H. Kim 
Published: February 2007

AbstractAlthough epithelial malignancies can have bone metastases, involvement of small bones is exceedingly rare, representing either first manifestation of an occult carcinoma or late disseminated disease. Small bone metastases may mimic primary skeletal diseases leading to misdiagnosis and delayed treatment. We report three cases of metastatic epithelial malignancies diagnosed by computed tomography (CT)‐guided fine‐needle aspiration (FNA) biopsy in two patients with lytic calcaneal lesions and a patellar lesion in a third patient; all with histologic confirmation. Case 1, a 63‐yr‐old female, presented with heel pain. FNA and tissue biopsy of the calcaneus revealed a clear cell malignancy consistent with a renal primary. Follow‐up abdominal CT scan revealed a renal lesion consistent with renal cell carcinoma. Case 2, a 37‐yr‐old male with squamous cell carcinoma of the esophagus, presented with foot pain. FNA and tissue biopsy of the calcaneus revealed metastatic squamous cell carcinoma. Case 3, a 52‐yr‐old male with a history of squamous cell carcinoma of floor of mouth, presented with knee pain and swelling. FNA and tissue biopsy of the patella revealed metastatic squamous cell carcinoma. To the best of our knowledge, this is the first complete FNA cytology report with histologic confirmation of unusual small bone metastases of the feet and patella from epithelial malignancies and shows the value of FNA cytology in establishing a correct diagnosis, and excluding primary skeletal diseases. © 1995 Wiley‐Liss, Inc.
Lobular carcinoma of the breast: Cytological features supporting the diagnosis of lobular cancer
Authors: Robinson I. A. , McKee G. , Jackson P. A. , Cook M. G. , Kissin M. W. 
Published: February 2007

AbstractLobular carcinomas have a distinct natural history with a better response to endocrine therapy and a higher incidence of local recurrence and are more often bilateral. The cytological diagnosis of lobulur carcinoma permits a discriminating therapeutic approach with pre‐operative Tamoxifen, more generous resection margins, and assessment of the contralateral breast. The cytological features of lobular cancer however are not well defined and the low cell yield from such neoplasms can result in a high false negative rate.To determine whether we could improve the pre‐operative diagnosis, we reviewed the cytological features of 112 lobular carcinomas. They had small uniform sized nuclei with irregular outlines and inconspicuous nucleoli. The degree of dissociation was similar to duct carcinomas and the incidence of inadequate aspirates was no higher. We found no features that confidently diagnosed lobular cancer or its sub‐types. However, using a combination of features, typing of lobular cancer on aspirated material is possible and should be attempted. © 1995 Wiley‐Liss, Inc.
Role of fine‐needle biopsy in the diagnosis of hydatid cyst
Authors: Saenz‐Santamaria Javier , Moreno‐Casado Jose , Nuñez Carlos 
Published: February 2007

AbstractThe cytopathologic findings in 17 patients with hydatid cyst are reported. All patients but one were referred for evaluation of a tumor mass. In 13 patients the aspirated material was diagnostic of hydatid cyst. In four patients only acellular laminated membranes were present in the aspirate and a presumptive cytopathologic diagnosis of hydatid cyst was made. Subsequent histologic studies confirmed the diagnosis of hydatidosis in all patients. No complications were encountered. Fine‐needle biopsy appears a safe diagnostic approach in the evaluation of suspected hydatid disease. The presence of acellular laminated membranes confirm the diagnosis of hydatid cyst. © 1995 Wiley‐Liss, Inc.
Solid and cystic papillary neoplasm of the pancreas: A clinico‐cytopathologic and immunocytochemical study of five new cases diagnosed by fine‐needle aspiration cytology and a review of the literature
Authors: Pelosi Giuseppe , Iannucci Antonio , Zamboni Giuseppe , Bresaola Enrica , Iacono Calogero , Serio Giovanni 
Published: February 2007

AbstractWe report here on five new cases of solid and cystic papillary neoplasm (SCPN) of the pancreas diagnosed by fine‐needle aspiration cytology (FNAC). All cytologic samples were obtained by ultrasonography, and the smears were conventionally fixed and stained. Special histochemical and immunocytochemical stains were also performed in some samples. Cytology revealed in all but one case numerous pseudopapillary structures composed of fibrovascular stalks lined with one or more layers of bland‐appearing, uniform tumor cells. The tumor cells had round‐to‐oval euchromatic nuclei with frequently folded smooth contours and one or two small nucleoli. Their cytoplasm often contained eosinophilic, PAS‐positive, and diastase‐resistant inclusions. Foamy cells, psammoma bodies, blood, and cellular debris were found in the background. The criteria for the differential diagnosis versus other pancreatic lesions are discussed in some detail, as is the role of immunocytochemistry (ICC). In the literature, only 28 cases of cytologically investigated SCPN have been reported to the best of our knowledge. The most helpful criteria for the conclusive identification of SCPN by FNAC include the pseudopapillary arrangement with bland‐appearing tumor cells, and, especially, the finding of acidophilic, PAS‐positive, and diastase‐resistant cytoplasmic granules. © 1995 Wiley‐Liss, Inc.
Typing and grading breast carcinoma on fine‐needle aspiration: Is this clinically useful information?
Authors: Robinson I. A. , McKee G. , Kissin M. W. 
Published: February 2007

AbstractThe ability of fine‐needle aspiration (FNA) to diagnose breast cancer is beyond question. The established role of cytopathology is to maintain a low benign to malignant biopsy ratio by reducing the number of benign lesions excised. Both typing and grading of breast cancers on FNA have received attention in the cytology literature but how this knowledge can influence management has not been fully explored.Recently we described a method for the cytological grading of breast cancer that compares well with the established Bloom and Richardson grades. In this paper we present our experience of 1,387 breast cancer FNAs reported by us with histological verification. We show that cytologically typing and grading breast cancers are valid exercises that can predict the true nature of the neoplasm. This information may assist in the clinical approach to the malignant breast. © 1995 Wiley‐Liss, Inc.
Cytospins—an alternative method for fine‐needle aspiration cytology of the breast: A study of 148 cases
Authors: Sirkin Wilma , Auger Manon , Donat Eva , Lipa Michael 
Published: February 2007

AbstractThe aim of this study was to evaluate the cytospin technique as an alternative method to prepare fine‐needle aspiration (FNA) specimens of the breast. To do so, the cytology of 148 breast FNAs that had been prepared by the cytospin technique and that had histologic correlation, was reviewed. All the cases that were diagnosed as malignant by cytology were proved malignant after surgical excision, and there were no false‐positive results. All but two cases diagnosed as benign by cytology proved to be benign on excision. The two false‐negative cases were missed due to sampling error. The cytological features seen on cytospins were similar to those seen on conventional direct smears. The major advantage of this method is that no aspirate is unsatisfactory due to unskilled direct smear technique. This, along with its good correlation with histology, proves that the cytospin method is an effective alternative to conventional direct smears for breast FNA. © 1995 Wiley‐Liss, Inc.
Aspiration cytology of chromophobe cell carcinoma of the kidney
Authors: Akhtar Mohammed , Ali M. Ashraf 
Published: February 2007

AbstractFine‐needle aspiration biopsy findings in three cases of chromophobe cell carcinoma are described and correlated with histologic and ultrastructural observations. In addition, comparisons are made with three cases each of oncocytoma and granular cell carcinoma. The cells in aspiration smears from chromophobe cell carcinoma closely correlated with histologic pattern of three cell types which were not present in oncocytomas and granular cell carcinomas. These cells had prominent cell borders, and their cytoplasm was either opaque and granular (type I) or variably translucent and reticular (type II and III). Ultrastructurally, the translucent areas within the cytoplasm contained large numbers of microvesicles which were unique to chromophobe cell carcinoma and were not seen in other neoplasms. Fine‐needle aspiration may be used to diagnose chromophobe cell carcinoma and distinguish it from other related renal neoplasms. © 1995 Wiley‐Liss, Inc.