bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasonic irrigation flows in root canals: effects of ultrasound power and file insertion depth
Authors: Koulogiannis A. , Walmsley A. D. , Angeli P. , Balabani S. 
Published: March 2024

AbstractUltrasonic irrigation during root canal treatment can enhance biofilm disruption. The challenge is to improve the fluid flow so that the irrigant reaches areas inaccessible to hand instrumentation. The aim of this study is to experimentally investigate how the flow field and hydrodynamic forces induced by ultrasonic irrigation are influenced by the ultrasound power and file insertion depth. A root canal phantom was 3D printed and used as a mold for the fabrication of a PDMS channel. An ultrasonic instrument with a #15K-file provided the irrigation. The flow field was studied by means of Particle Image Velocimetry (PIV). The time averaged velocity and shear stress distributions were found to vary significantly with ultrasound power. Their maximum values increase sharply for low powers and up to a critical power level. At and above this setting, the flow pattern changes, from the high velocity and shear stress region confined in the vicinity of the tip, to one covering the whole root canal domain. Exceeding this threshold also induces a moderate increase in the maximum velocities and shear stresses. The insertion depth was found to have a smaller effect on the measured velocity and shear stresses. Due to the oscillating nature of the flow, instantaneous maximum velocities and shear stresses can reach much higher values than the mean, especially for high powers. Ultrasonic irrigation will benefit from using a higher power setting as this does produce greater shear stresses near the walls of the root canal leading to the potential for increased biofilm removal.
Understanding scholar-trajectories across scientific periodicals
Authors: Fan Yangliu , Blok Anders , Lehmann Sune 
Published: March 2024

AbstractDespite the rapid growth in the number of scientific publications, our understanding of author publication trajectories remains limited. Here we propose an embedding-based framework for tracking author trajectories in a geometric space that leverages the information encoded in the publication sequences, namely the list of the consecutive publication venues for each scholar. Using the publication histories of approximately 30,000 social media researchers, we obtain a knowledge space that broadly captures essential information about periodicals as well as complex (inter-)disciplinary structures of science. Based on this space, we study academic success through the prism of movement across scientific periodicals. We use a measure from human mobility, the radius of gyration, to characterize individual scholars' trajectories. Results show that author mobility across periodicals negatively correlates with citations, suggesting that successful scholars tend to publish in a relatively proximal range of periodicals. Overall, our framework discovers intricate structures in large-scale sequential data and provides new ways to explore mobility and trajectory patterns.
Association of periodontal disease treatment with mortality in patients with dementia: a population-based retrospective cohort study (2002–2018)
Authors: Cho Han-A , Kim Bo-Ra , Shin Hosung 
Published: March 2024

AbstractDementia is one of the leading causes of death worldwide. In this study, we analyzed the association of periodontal treatment with the risk of death in patients with dementia. The analyzed data were obtained by linking the National Health Insurance Corporation claims data between 2002 and 2018 to the Statistics Korea death registry. In total, 1,131,406 patients with dementia aged ≥ 65 years had undergone dental treatment during the study period. Time-dependent Cox proportional hazards model was performed. The mortality rate was approximately 10% among the patients with dementia. The 17-years cumulative survival rates for patients who received periodontal treatment and their untreated counterparts were 83.5% and 71.5%, respectively. The crude hazard ratio of the periodontal group was approximately twice as high as that of the non-periodontal group (1.99;P < 0.001). Furthermore, in the regression model that was adjusted for socio-demographic variables and systematic chronic diseases, the risk of death in the non-periodontal group was approximately 1.83 times higher than that of the periodontal group (P < 0.00). These findings suggest that preventive periodontal treatment may decrease mortality risk in older people with dementia.
MAX controls meiotic entry in sexually undifferentiated germ cells
Authors: Suzuki Ayumu , Uranishi Kousuke , Nishimoto Masazumi , Mizuno Yosuke , Mizuno Seiya , Takahashi Satoru , Eisenman Robert N. , Okuda Akihiko 
Published: March 2024

AbstractMeiosis is a specialized type of cell division that occurs physiologically only in germ cells. We previously demonstrated that MYC-associated factor X (MAX) blocks the ectopic onset of meiosis in embryonic and germline stem cells in culture systems. Here, we investigated the Max gene’s role in mouse primordial germ cells. Although Max is generally ubiquitously expressed, we revealed that sexually undifferentiated male and female germ cells had abundant MAX protein because of their higher Max gene expression than somatic cells. Moreover, our data revealed that this high MAX protein level in female germ cells declined significantly around physiological meiotic onset. Max disruption in sexually undifferentiated germ cells led to ectopic and precocious expression of meiosis-related genes, including Meiosin, the gatekeeper of meiotic onset, in both male and female germ cells. However, Max-null male and female germ cells did not complete the entire meiotic process, but stalled during its early stages and were eventually eliminated by apoptosis. Additionally, our meta-analyses identified a regulatory region that supports the high Max expression in sexually undifferentiated male and female germ cells. These results indicate the strong connection between the Max gene and physiological onset of meiosis in vivo through dynamic alteration of its expression.
Evolutionary and synteny analysis of HIS1, BADH2, GBSS1, and GBSS2 in rice: insights for effective introgression breeding strategies
Authors: Lim Insu , Park Yong-Jin , Ha Jungmin 
Published: March 2024

AbstractThe key genes BADH2, GBSS1, GBSS2, and HIS1 regulate the fragrance, starch synthesis, and herbicide resistance in rice. Although the molecular functions of four genes have been investigated in the Oryza sativa species, little is known regarding their evolutionary history in the Oryza genus. Here, we studied the evolution of four focal genes in 10 Oryza species using phylogenetic and syntenic approaches. The HIS1 family underwent several times of tandem duplication events in the Oryza species, resulting in copy number variation ranging from 2 to 7. At most one copy of BADH2, GBSS1, and GBSS2 orthologs were identified in each Oryza species, and gene loss events of BADH2 and GBSS2 were identified in three Oryza species. Gene transfer analysis proposed that the functional roles of GBSS1 and GBSS2 were developed in the Asian and African regions, respectively, and most allelic variations of BADH2 in japonica rice emerged after the divergence between the Asian and African rice groups. These results provide clues to determine the origin and evolution of the key genes in rice breeding as well as valuable information for molecular breeders and scientists to develop efficient strategies to simultaneously improve grain quality and yield potential in rice.
Asymmetric dual-core liquid crystal channel-based tunable mode converter
Authors: Esmail Mohamed Saleh Mohamed , Hameed Mohamed Farhat O. , Obayya Salah S. A. , Younis B. M. 
Published: March 2024

AbstractIn this work, a higher order-to-fundamental mode converter is reported and analyzed based on an asymmetric dual channel waveguide (ADC-WG) on silicon. In the reported structure, one of the two waveguides is infiltrated with nematic liquid crystal (NLC) material to add temperature tunability while the other one is a solid BK7 waveguide. The modal characteristics are obtained using the full vectorial finite difference method (FVFDM). In addition, the structural parameters and optical characteristics of the employed materials are investigated to achieve good wavelength selectivity with a short device length (LD). Thus, a compact mode converter that can work at different wavelengths including the telecommunication wavelength i.e., 1.55 μm with LD ~ 482.31 μm and a low crosstalk of − 19.86 dB is presented. To prove the thermal tunability of the suggested mode converter, its operation is tested through a temperature range between 20 and 35 °C and the results show that the mode conversion process is achieved at each temperature with different phase matching wavelengths (λPMW) but with quite similar coupling length (LC). The proposed device can therefore be effectively utilized in integrated photonic circuits.
Craniocervical posture in patients with skeletal malocclusion and its correlation with craniofacial morphology during different growth periods
Authors: Peng Houli , Liu Weihan , Yang Lanxin , Yan Pingping , Zhong Wenjie , Gao Xiang , Song Jinlin 
Published: March 2024

AbstractThe association between craniocervical posture and craniofacial structures in the various sagittal skeletal malocclusion during different growth stages has been the focus of intense interest in fields of orthodontics, but it has not been conclusively demonstrated. Thus, this study aimed to investigate the association between craniofacial morphology and craniocervical posture in patients with sagittal skeletal malocclusion during different growth periods. A total of 150 from a large pool of cephalograms qualified for the inclusion and exclusion were evaluated and classified into three groups according to the Cervical Vertebral Maturation (CVM) by examining the morphological modifications of the second through fourth cervical vertebrae, each group consisted of 50 cephalograms. In each growth period, for the comparison of head and cervical posture differences among various skeletal classes, the radiographs were further subdivided into skeletal Class I (0° < ANB < 5°, n = 16), skeletal Class II (ANB ≥ 5°, n = 18), and skeletal Class III (0° ≤ ANB, n = 16) on the basis of their ANB angle. There was no significant difference in gender (P > 0.05). Some variables were found to be significant during pubertal growth and later in patients with sagittal skeletal malocclusion (P < 0.05). Most indicators describing craniocervical posture were largest in skeletal Class II and smallest in skeletal Class III during the peak growth periods and later. Cervical inclination variables were greater in skeletal Class III than in skeletal Class II. Variables of craniofacial morphology and craniocervical posture are more correlated during the pubertal growth period and later in patients with sagittal skeletal malocclusion. A tendency is an indication of the close interrelationship that a more extended head was in skeletal Class II while a flexed head was in skeletal Class III. Nevertheless, with the considerations of some limitations involved in this study, further longitudinal studies with large samples are required to elucidate the relationship clearly.
Self-replicating segregation patterns in horizontally vibrated binary mixture of granules
Authors: Ebata Hiroyuki , Inagaki Shio 
Published: March 2024

AbstractFluidized granular mixtures of various particle sizes exhibit intriguing patterns as different species segregate and condense. However, understanding the segregation dynamics is hindered by the inability to directly observe the time evolution of the internal structure. We discover self-replicating bands within a quasi-2D container subjected to horizontal agitation, resulting in steady surface waves. Through direct observation of surface flow and evolving internal structures, we reveal the crucial role of coupling among segregation, surface flow, and hysteresis in granular fluidity. We develop Bonhoeffer-van der Pol type equations grounded in experimental observations, reproducing complex band dynamics, such as replication, oscillation, and breathing. It suggests the similarity between pattern formation in granular segregation and that in reaction–diffusion systems.
Toxoplasma gondii infection associated with inflammasome activation and neuronal injury
Authors: Andreou Dimitrios , Steen Nils Eiel , Mørch-Johnsen Lynn , Jørgensen Kjetil Nordbø , Wortinger Laura A. , Barth Claudia , Szabo Attila , O’Connell Kevin S. , Lekva Tove , Hjell Gabriela , Johansen Ingrid Torp , Ormerod Monica B. E. G. , Haukvik Unn K. , Aukrust Pål , Djurovic Srdjan , Yolken Robert H. , Andreassen Ole A. , Ueland Thor , Agartz Ingrid 
Published: March 2024

AbstractToxoplasma gondii (TOXO) infection typically results in chronic latency due to its ability to form cysts in the brain and other organs. Latent toxoplasmosis could promote innate immune responses and impact brain function. A large body of evidence has linked TOXO infection to severe mental illness (SMI). We hypothesized that TOXO immunoglobulin G (IgG) seropositivity, reflecting previous infection and current latency, is associated with increased circulating neuron-specific enolase (NSE), a marker of brain damage, and interleukin-18 (IL-18), an innate immune marker, mainly in SMI. We included 735 patients with SMI (schizophrenia or bipolar spectrum) (mean age 32 years, 47% women), and 518 healthy controls (HC) (mean age 33 years, 43% women). TOXO IgG, expressed as seropositivity/seronegativity, NSE and IL-18 were measured with immunoassays. We searched for main and interaction effects of TOXO, patient/control status and sex on NSE and IL-18. In the whole sample as well as among patients and HC separately, IL-18 and NSE concentrations were positively correlated (p < 0.001). TOXO seropositive participants had significantly higher NSE (3713 vs. 2200 pg/ml, p < 0.001) and IL-18 levels (1068 vs. 674 pg/ml, p < 0.001) than seronegative participants, and evaluation within patients and HC separately showed similar results. Post-hoc analysis on cytomegalovirus and herpes simplex virus 1 IgG status showed no associations with NSE or IL-18 which may suggest TOXO specificity. These results may indicate ongoing inflammasome activation and neuronal injury in people with TOXO infections unrelated to diagnosis.
The role of school functioning, physical activity, BMI, sex and age in building resilience among Ukrainian refugee children in Poland
Authors: Korcz Agata , Cieśla Elżbieta , Urbański Piotr 
Published: March 2024

AbstractThe study aims to examine the relationship between school functioning, physical activity (PA), sex, Body Mass Index (BMI), age, and resilience in Ukrainian children who migrated to Poland due to the war. A cross-sectional study was conducted in 2022, focusing on 248 children aged 10–15 years. The findings suggest that school environment, including enjoyment of school and strong support from teachers, plays a significant role in building resilience in children. PA enhanced the resilience of girls, whereas a higher BMI negatively impacted it. A child-friendly school environment that encourages PA and provides social support could be a promising approach for the mental health of Ukrainian refugee children.
Automatic measurement of fetal anterior neck lower jaw angle in nuchal translucency scans
Authors: Peng Yulin , Luo Yingchun , Yan Junyi , Li Wenjuan , Liao Yimin , Yan Lingyu , Ling Hefei , Long Can 
Published: March 2024

AbstractThis study aims at suggesting an end-to-end algorithm based on a U-net-optimized generative adversarial network to predict anterior neck lower jaw angles (ANLJA), which are employed to define fetal head posture (FHP) during nuchal translucency (NT) measurement. We prospectively collected 720 FHP images (half hyperextension and half normal posture) and regarded manual measurement as the gold standard. Seventy percent of the FHP images (half hyperextension and half normal posture) were used to fit models, and the rest to evaluate them in the hyperextension group, normal posture group (NPG), and total group. The root mean square error, explained variation, and mean absolute percentage error (MAPE) were utilized for the validity assessment; the two-sample t test, Mann–Whitney U test, Wilcoxon signed-rank test, Bland–Altman plot, and intraclass correlation coefficient (ICC) for the reliability evaluation. Our suggested algorithm outperformed all the competitors in all groups and indices regarding validity, except for the MAPE, where the Inception-v3 surpassed ours in the NPG. The two-sample t test and Mann–Whitney U test indicated no significant difference between the suggested method and the gold standard in group-level comparison. The Wilcoxon signed-rank test revealed significant differences between our new approach and the gold standard in personal-level comparison. All points in Bland–Altman plots fell between the upper and lower limits of agreement. The inter-ICCs of ultrasonographers, our proposed algorithm, and its opponents were graded good reliability, good or moderate reliability, and moderate or poor reliability, respectively. Our proposed approach surpasses the competition and is as reliable as manual measurement.
Evidence for long-term efficacy of a membrane filtration device in rural villages in Ghana
Authors: Boaheng Joseph Marfo , Raimann Jochen G. , Narh Philip , Johnson Seth , Donald Linda L. , Mati Harrison Kwame , Port Friedrich K. , Levin Nathan W. 
Published: March 2024

AbstractDrinking water contaminated by pathogenic micro-organisms increases the risk of infectious gastrointestinal disease which could potentially lead to acute kidney injury and even death, particularly amongst the young and the elderly. Earlier studies have shown a substantial reduction in the incidence of diarrheal disease over a period of one year using a polysulfone membrane water gravity-powered water filtration device. The current report is a continuation of these studies to assess the long-term effects of the innovative method on diarrheal incidence rates over a 4-year follow-up period. This follow-up study monitored the trend of self-reported diarrheal events in all households in the previously studied villages for 5 months, in the last half of each study year, using the same questionnaire utilized in the earlier study. Three villages that had no device yet installed served as controls. We computed monthly diarrheal incidence rates for all study years (standardized to per 100 person-months) and compared these to the pre-device incidence rate in 2018 and in the control group, using the Wilcoxon rank sum exact test. The average diarrheal incidence rates of 1.5 p100pm in 2019, 2.19 p100pm in 2021, and 0.54p100pm in 2022 were significantly different from an earlier study that reported 17.8 p100pm rates before the devices were installed in 2018, (all p-values < 0.05). Concomitantly, self-reported diarrheal infections were substantially higher in the “control villages” not yet having the filtration device installed (80.9, 77.6, and 21.5 per 100 pm). The consistent and large reduction in diarrhea incidence documents the long-term efficacy of the use of the membrane filtration device. This simple water purification method using gravity flow improves public health in remote regions with limited resources.
Craniofacial bone anomalies related to cholesterol synthesis defects
Authors: Iwaya Chihiro , Suzuki Akiko , Shim Junbo , Kim Aemin , Iwata Junichi 
Published: March 2024

AbstractDHCR7 and SC5D are enzymes crucial for cholesterol biosynthesis, and mutations in their genes are associated with developmental disorders, which are characterized by craniofacial deformities. We have recently reported that a loss of either Dhcr7 or Sc5d results in a failure in osteoblast differentiation. However, it remains unclear to what extent a loss of function in either DHCR7 or SC5D affects craniofacial skeletal formation. Here, using micro computed tomography (μCT), we found that the bone phenotype differs in Dhcr7−/− and Sc5d−/− mice in a location-specific fashion. For instance, in Sc5d−/− mice, although craniofacial bones were overall affected, some bone segments, such as the anterior part of the premaxilla, the anterior–posterior length of the frontal bone, and the main body of the mandible, did not present significant differences compared to WT controls. By contrast, in Dhcr7−/− mice, while craniofacial bones were not much affected, the frontal bone was larger in width and volume, and the maxilla and palatine bone were hypoplastic, compared to WT controls. Interestingly the mandible in Dhcr7−/− mice was mainly affected at the condylar region, not the body. Thus, these results help us understand which bones and how greatly they are affected by cholesterol metabolism aberrations in Dhcr7−/− and Sc5d−/− mice.
Time-band network model and binary tree algorithm for multimodal irregular flight recovery
Authors: He Peinan 
Published: March 2024

AbstractRecovery of irregular flights caused by various reasons such as aircraft failures and airport closures is studied in this research and a multimodal time-band network model for solving the issue is proposed. It transforms the flight routing problem into a time-based network, which is used to obtain the delay and cancellation costs of each flight. With delay and cancellation costs as variables, the proposed model aims to minimize recovery costs under constraints. This research also suggests a developed binary tree algorithm, which improves the efficiency of model solving. The results show that the rescheduled flights and re-selected flight routes are at the lowest cost and helpful to achieve a balance of flight flow without affecting flight safety. This method used in this work shows its certain value in helping airlines restore flight operations in the shortest possible time and at the lowest cost, improving operational efficiency and service quality.
Applying explainable artificial intelligence methods to models for diagnosing personal traits and cognitive abilities by social network data
Authors: Panfilova Anastasia S. , Turdakov Denis Yu. 
Published: March 2024

AbstractThis study utilizes advanced artificial intelligence techniques to analyze the social media behavior of 1358 users on VK, the largest Russian online social networking service. The analysis comprises 753,252 posts and reposts, combined with Big Five personality traits test results, as well as assessments of verbal and fluid intelligence. The objective of this research is to understand the manifestation of psychological attributes in social media users' behavior and determine their implications on user-interaction models. We employ the integrated gradients method to identify the most influential feature groups. The partial dependence plot technique aids in understanding how these features function across varying severity degrees of the predicted trait. To evaluate feature stability within the models, we cluster calculated Shapley values. Our findings suggest that the emotional tone (joy, surprise, anger, fear) of posts significantly influences the prediction of three personality traits: Extraversion, Agreeableness, and Openness to Experience. Additionally, user social engagement metrics (such as friend count, subscribers, likes, views, and comments) correlate directly with the predicted level of Logical thinking. We also observe a trend towards provocative and socially reprehensible content among users with high Neuroticism levels. The theme of religion demonstrates a multidirectional relationship with Consciousness and Agreeableness. Further findings, including an analysis of post frequency and key text characteristics, are also discussed, contributing to our understanding of the complex interplay between social media behavior and psychological traits. The study proposes a transition from the analysis of correlations between psychological (cognitive) traits to the analysis of indicators of behavior in a social network that are significant for diagnostic models of the corresponding traits.