bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of environmental odor pollution using a dispersion model in an industrialized urban area of Kocaeli, Turkey
Authors: Ergün Yüksel Burcu , Çetin Doğruparmak Şenay , Pekey Beyhan , Pekey Hakan 
Published: March 2024

AbstractThe main goal of the present study was to highlight how crucial odor evaluation methods may be for raising the general standard of living in a region. For this, the dispersion of odor concentrations detected by an olfactometric method in an area of Kocaeli, Turkey, where odor problems are frequently experienced, was investigated using the AERMOD atmospheric dispersion modeling system. According to the findings of the olfactometric measurement, the mean odor concentrations in the industrial area was high at 1342 OU m–3, while in the residential areas the values were lower, at 578 OU m–3 within the selected study area. As a result of the modeling study, the maximum odor concentration was 2081 OU m–3 at the 1 h. The model also showed that the coordinate points where the maximum odor concentration was observed changed with time, and that the concentrations recorded at the 1 h may decrease by as much as 88%–91% at the 24 h. In the study, a survey was also conducted to identify possible effects of odor pollution on people. The survey findings showed a statistically significant difference (p < 0.05) between the two areas (industrial and residential) for seven variables of a total 28. We suggest that measuring odor concentrations, modeling their distribution, and conducting surveys are effective methods when managing the urban planning process.
A practical guide for assessing and managing cardiovascular risk during androgen‐deprivation therapy in patients with prostate cancer
Authors: Solanki Aum J. , Kamrava Mitchell , Posadas Edwin M. , Freedland Stephen J. , Ballas Leslie , Sandler Howard M. , Bairey Merz C. Noel , Atkins Katelyn M. , Nikolova Andriana P. 
Published: March 2024

AbstractProstate cancer is the most common malignancy among men worldwide, and androgen‐deprivation therapy (ADT) is a mainstay of treatment. There are observational data demonstrating an increased risk of cardiovascular events in patients who receive ADT, particularly those who have an elevated baseline cardiovascular risk. Because, for most patients with prostate cancer, death is predominantly from noncancer‐related causes, cardiovascular disease and its risk factors should be optimized during cancer treatment. This review provides an overview of the landscape of ADT treatment and serves as a guide for appropriate cardiovascular screening and risk‐mitigation strategies. The authors emphasize the importance of shared communication between the multidisciplinary cancer team and primary care to improve baseline cardiovascular screening and treatment of modifiable risk factors within this higher risk population.
Construction of dangling and staggered stacking aldehyde in covalent organic frameworks for 2e− oxygen reduction reaction
Authors: Zheng Shuang , Ouyang Zhaofeng , Liu Minghao , Bi Shuai , Liu Guojuan , Li Xuewen , Xu Qing , Zeng Gaofeng 
Published: March 2024

AbstractCovalent organic frameworks (COFs) have been utilized as the ideal candidates to preciously construct electrocatalysts. However, the highly ordered degree of COFs renders the catalytic centers closely stacked, which limits the utilization efficiency of catalytic sites. Herein, we have first constructed dangling and staggered‐stacking aldehyde (–CHO) from [4 + 3] COFs as catalytic centers for 2e− oxygen reduction reaction (ORR). The new catalytic COFs have unreacted dangling ‐CHO out of the COFs' planes, which are more easily exposed in electrolytes than the sites in the frameworks. More importantly, these –CHO adopt staggered stacking models, and thus provide larger space for mass transport than those with eclipsed stacking models. In addition, by tuning the triratopic linkers in the COFs, the catalytic properties are well modulated. The optimized COF shows high selectivity and activity for 2e− ORR, with H2O2 selectivity of 91%, and mass activity of 12.2 A g−1, respectively. The theoretical calculation further reveals the higher activity for the pyridine‐contained B18C6‐PTTA‐COF due to the promoted binding ability of the intermediate OOH* at the carbon in dangling –CHO. This work provides us with a new insight into designing electrocatalysts based on COFs.
Cellular and molecular mechanisms involved in the analgesic effects of botulinum neurotoxin: A literature review
Authors: Hosseindoost Saereh , Inanloo Seyed Hassan , Pestehei Seyed Khalil , Rahimi Mojgan , Yekta Reza Atef , Khajehnasiri Alireza , Rad Maziyar Askari , Majedi Hossein , Dehpour Ahmad Reza 
Published: March 2024

AbstractBotulinum neurotoxins (BoNTs), derived from Clostridium botulinum, have been employed to treat a range of central and peripheral neurological disease. Some studies indicate that BoNT may be beneficial for pain conditions as well. It has been hypothesized that BoNTs may exert their analgesic effects by preventing the release of pain‐related neurotransmitters and neuroinflammatory agents from sensory nerve endings, suppressing glial activation, and inhibiting the transmission of pain‐related receptors to the neuronal cell membrane. In addition, there is evidence to suggest that the central analgesic effects of BoNTs are mediated through their retrograde axonal transport. The purpose of this review is to summarize the experimental evidence of the analgesic functions of BoNTs and discuss the cellular and molecular mechanisms by which they can act on pain conditions. Most of the studies reviewed in this article were conducted using BoNT/A. The PubMed database was searched from 1995 to December 2022 to identify relevant literature.
The contribution of the WNT pathway to the therapeutic effects of montelukast in experimental murine airway inflammation induced by ovalbumin and lipopolysaccharide
Authors: Kaya‐Yasar Yesim , Engin Seckin , Barut Elif Nur , Inan Cihan , Saygin Ismail , Erkoseoglu Ilknur , Sezen Sena F. 
Published: March 2024

AbstractThe wingless/integrase‐1 (WNT) pathway involved in the pathogenesis of inflammatory airway diseases has recently generated considerable research interest. Montelukast, a leukotriene receptor antagonist, provides therapeutic benefits in allergic asthma involving eosinophils. We aimed to investigate the role of the WNT pathway in the therapeutic actions of montelukast (MT) in a mixed type of allergic‐acute airway inflammation model induced by ovalbumin (OVA) and lipopolysaccharide (LPS) in mice. Female mice were sensitized with intraperitoneal OVA‐Al(OH)3administration in the initiation phase and intranasal OVA followed by LPS administration in the challenge phase. The mice were divided into eight groups: control, asthmatic, and control/asthmatic treated with XAV939 (inhibitor of the canonical WNT pathway), LGK‐974 (inhibitor of the secretion of WNT ligands), or MT at different doses. The inhibition of the WNT pathway prevented tracheal 5‐HT and bradykinin hyperreactivity, while only the inhibition of the canonical WNT pathway partially reduced 5‐HT and bradykinin contractions compared to the inflammation group. Therefore, MT treatment hindered 5‐HT and bradykinin hyperreactivity associated with airway inflammation. Furthermore, MT prevented the increases in the phosphorylated GSK‐3β and WNT5A levels, which had been induced by airway inflammation, in a dose‐dependent manner. Conversely, the MT application caused a further increase in the fibronectin levels, while there was no significant alteration in the phosphorylation of the Smad‐2 levels in the isolated lungs of the mice. The MT treatment reversed the increase in the mRNA expression levels of interleukin‐17A. An increase in eosinophil and neutrophil counts was observed in bronchoalveolar lavage fluid samples obtained from the mice in the inflammation group, which was hampered by the MT treatment. The inhibition of the WNT pathway did not alter inflammatory cytokine expression or cell infiltration. The WNT pathway mediated the therapeutic effects of MT due to the inhibition of GSK‐3β phosphorylation as well as the reduction of WNT5A levels in a murine airway inflammation model.
Care, control and complications of hospitalised patients with type 1 diabetes in China: A nationwide‐based registry study
Authors: Deng Chao , Xie Yuting , Li Juan , Jiang Hongwei , Niu Xiaohong , Yan Dewen , Su Heng , Kuang Hongyu , Tian Liming , Liu Jing , Jiang Sheng , Quan Huibiao , Xu Jixiong , Wu Xiaohong , Tao Na , Sun Shuguang , Tang Xiaohan , Chen Yan , Fan Li , Li Xia , Zhou Zhiguang ,   the CD1S Study Group
Published: March 2024

AbstractAimsTo evaluate the status quo of type 1 diabetes (T1D) management and characteristics of hospitalised patients with T1D in China through a nationwide multicentre registry study, the China Diabetes Type 1 Study (CD1S).Materials and MethodsClinical data from the electronic hospital records of all people with T1D were retrospectively collected in 13 tertiary hospitals across 7 regions of China from January 2016 to December 2021. Patients were defined as newly diagnosed who received a diagnosis of diabetes for less than 3 months.ResultsAmong the 4993 people with T1D, the median age (range) at diagnosis was 23.0 (1.0‐87.0) years and the median disease duration was 2.0 years. The median haemoglobin A1c (HbA1c) level was 10.7%. The prevalence of obesity, overweight, dyslipidemia, and hypertension were 2.5%, 10.8%, 62.5% and 25.9%, respectively. The incidence rate of diabetic ketoacidosis at disease onset was 41.1%, with the highest in children <10 years of age (50.6%). In patients not newly diagnosed, 60.7% were diagnosed with at least one chronic diabetic complication, with the highest proportion (45.3%) of diabetic peripheral neuropathy. Chronic complications were detected in 79.2% of people with T1D duration ≥10 years.ConclusionsIn the most recent years, there were still unsatisfactory metabolic control and high incidence of diabetic ketoacidosis as well as chronic diabetic complications among inpatients with T1D in China. The ongoing CD1S prospective study aims to improve the quality of T1D management nationally.
Magnetically responsive manipulation of droplets and bubbles
Authors: Jiang Shaojun , Wu Dong , Li Jiawen , Chu Jiaru , Hu Yanlei 
Published: March 2024

AbstractDroplets and bubbles have a wide range of applications in industry, agriculture, and daily life, and their controllable manipulation is of significant scientific and technological importance. Versatile magnetically responsive manipulation strategies have been developed to achieve precise control over droplets and bubbles. To manipulate nonmagnetic droplets or bubbles with magnetic fields, the presence of magnetic medium is indispensable. Magnetic additives can be added to the surface or interior of droplets and bubbles, allowing for on‐demand manipulation by direct magnetic actuation. Alternatively, magnetically responsive elastomer substrates can be used to actuate droplets and bubbles by controlling the deformation of microstructures on the substrates through magnetic stimulation. Another strategy is based on untethered magnetic devices, which enables free mobility, facilitating versatile manipulation of droplets and bubbles in a flexible manner. This paper reviews the advances in magnetically responsive manipulation strategies from the perspective of droplets and bubbles. An overview of the different classes of magnetic medium, along with their respective corresponding droplet/bubble manipulation methods and principles, is first introduced. Then, the applications of droplet/bubble manipulation in biomedicine, microchemistry, and other fields are presented. Finally, the remaining challenges and future opportunities related to regulating droplet/bubble behavior using magnetic fields are discussed.
Bibliometric analysis of research challenges and trends in urban underground space
Authors: Zhang You , Zheng Liang , He Lingling , Jiao Yuyong , Peng Hanfa , Gamage Ranjith P. 
Published: March 2024

AbstractThe utilization and development of urban underground space play a crucial role in optimizing the layout of civic architecture and enhancing the urban ecological environment, which contributes toward increasing the overall carrying capacity and promoting sustainable development in megacities. To delve into the research progress of urban underground space, knowledge maps were created using the information visualization software VOSviewer. The literature was systematically extracted from three prominent databases, namely, Web of Science, Scopus, and China National Knowledge Infrastructure. According to the bibliometric analysis of the co‐citation and core words co‐occurrence, the trends and challenges of research on urban underground space were identified. As highlighted by the results obtained, it still remains highly challenging to achieve interdisciplinary collaboration in urban underground space research; the research trends of urban underground space consist of collaborative planning and whole life cycle sustainable development, multisource geological data informatization and resource evaluation, infrastructure design optimization, and intelligent construction. The knowledge map, drawn using bibliometric methods, offers a quantitative analysis of literature retrieval across various levels. It is recognized as an essential tool for exploring and identifying challenges and trends in urban underground space.
Proteomic profiles of left atrial volume and its influence on response to spironolactone: Findings from the HOMAGE trial and STANISLAS cohort
Authors: Kobayashi Masatake , Ferreira João Pedro , Duarte Kevin , Bresso Emmanuel , Huttin Olivier , Bozec Erwan , Brunner La Rocca Hans‐Peter , Delles Christian , Clark Andrew L. , Edelmann Frank , González Arantxa , Heymans Stephane , Pellicori Pierpaolo , Petutschnigg Johannes , Verdonschot Job A.J. , Rossignol Patrick , Cleland John G.F. , Zannad Faiez , Girerd Nicolas ,   the HOMAGE Trial Committees and Investigators
Published: March 2024

AimsHigh left ventricular filling pressure increases left atrial volume and causes myocardial fibrosis, which may decrease with spironolactone. We studied clinical and proteomic characteristics associated with left atrial volume indexed by body surface area (LAVi), and whether LAVi influences the response to spironolactone on biomarker expression and clinical variables.Methods and resultsIn the HOMAGE trial, where people at risk of heart failure were randomized to spironolactone or control, we analysed 421 participants with available LAVi and 276 proteomic measurements (Olink) at baseline, month 1 and 9 (mean age 73 ± 6 years; women 26%; LAVi 32 ± 9 ml/m2). Circulating proteins associated with LAVi were also assessed in asymptomatic individuals from a population‐based cohort (STANISLAS; n = 1640; mean age 49 ± 14 years; women 51%; LAVi 23 ± 7 ml/m2). In both studies, greater LAVi was significantly associated with greater left ventricular masses and volumes. In HOMAGE, after adjustment and correction for multiple testing, greater LAVi was associated with higher concentrations of matrix metallopeptidase‐2 (MMP‐2), insulin‐like growth factor binding protein‐2 (IGFBP‐2) and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) (false discovery rates [FDR] <0.05). These associations were externally replicated in STANISLAS (all FDR <0.05). Among these biomarkers, spironolactone decreased concentrations of MMP‐2 and NT‐proBNP, regardless of baseline LAVi (pinteraction > 0.10). Spironolactone also significantly reduced LAVi, improved left ventricular ejection fraction, lowered E/e', blood pressure and serum procollagen type I C‐terminal propeptide (PICP) concentration, a collagen synthesis marker, regardless of baseline LAVi (pinteraction > 0.10).ConclusionIn individuals without heart failure, LAVi was associated with MMP‐2, IGFBP‐2 and NT‐proBNP. Spironolactone reduced these biomarker concentrations as well as LAVi and PICP, irrespective of left atrial size.
Self‐propulsion of a droplet induced by combined diffusiophoresis and Marangoni effects
Authors: Wang Yuhang , Zheng Longtao , Li Gaojin 
Published: March 2024

AbstractChemically active droplets display complex self‐propulsion behavior in homogeneous surfactant solutions, often influenced by the interplay between diffusiophoresis and Marangoni effects. Previous studies have primarily considered these effects separately or assumed axisymmetric motion. To understand the full hydrodynamics, we investigate the motion of a two‐dimensional active droplet under their combined influences using weakly nonlinear analysis and numerical simulations. The impact of two key factors, the Péclet number () and the mobility ratio between diffusiophoretic and Marangoni effects (), on droplet motion is explored. We establish a phase diagram in the space, categorizing the boundaries between four types of droplet states: stationary, steady motion, periodic/quasi‐periodic motion, and chaotic motion. We find that the mobility ratio does not affect the critical for the onset of self‐propulsion, but it significantly influences the stability of high‐wavenumber modes as well as the droplet's velocity and trajectory. Scaling analysis reveals that in the high regime, the Marangoni and diffusiophoresis effects lead to distinct velocity scaling laws: and , respectively. When these effects are combined, the velocity scaling depends on the sign of the mobility ratio. In cases with a positive mobility ratio, the Marangoni effect dominates the scaling, whereas the negative diffusiophoretic effect leads to an increased thickness of the concentration boundary layer and a flattened scaling of the droplet velocity.
Optimal selection and scaling of ground motion records compatible with input energy and acceleration spectra
Authors: Hasanoğlu Serkan , Güllü Ahmet , Dindar Ahmet Anıl , Müderrisoğlu Ziya , Özkaynak Hasan , Bozer Ali 
Published: March 2024

AbstractNonlinear response history analysis is the primary tool for risk‐targeted design and seismic performance evaluation of structures. These analyses require the selection of a set of ground motions that satisfy predetermined conditions such as spectral acceleration. Numerous efforts have been made so far to obtain ground motion records which are expected to represent possible earthquakes. Even though spectral acceleration‐based ground motion scaling is a common procedure, recent studies showed that structural response can be better represented through the energy content of the records. To this end, this study aims to develop an energy and acceleration spectra‐compatible record selection and scaling methodology to achieve higher efficiency and lower bias in the predicted structural response. The efficiency of the proposed method is evaluated through the standard deviations of the computed story drifts of benchmark structures resulting from the records processed by either the proposed or commonly used methods. The results demonstrated that considering input energy together with spectral acceleration for the selection and scaling of the records can considerably reduce the bias in structural response, especially for structures located on stiff soils.
Eating disorder symptom non‐endorsers in hospitalised patients with anorexia nervosa: Who are they?
Authors: Vanzhula Irina , Hagan Kelsey , Duck Sarah Ann , Pan Isabella , Wang Erin Y. , Steinglass Joanna , Attia Evelyn , Wildes Jennifer E. , Guarda Angela S. , Schreyer Colleen 
Published: March 2024

AbstractObjectiveImpaired insight and illness denial are common in anorexia nervosa (AN). Missing an AN diagnosis may delay treatment and negatively impact outcomes.MethodThe current retrospective study examined the prevalence and characteristics of AN symptom non‐endorsement (i.e., scoring within the normal range on the Eating Disorder Examination Questionnaire [EDE‐Q] or the Eating Disorder Examination [EDE] interview) in three independent samples of hospitalised patients with AN (N1 = 154; N2 = 300; N3 = 194). A qualitative chart review of a subsample of non‐endorsers (N4 = 32) extracted reports of disordered eating behaviours observed by the treatment team.ResultsThe prevalence of non‐endorsement ranged from 11% to 34% across sites. Non‐endorsers were more likely to be diagnosed with AN restricting type (AN‐R) and reported fewer symptoms of co‐occurring psychopathology than endorsers. Groups benefitted equally from treatment. The qualitative chart review indicated that objective symptoms of AN were recorded by staff in over 90% of non‐endorsers.ConclusionsEating disorder symptom assessments using the EDE‐Q or EDE may miss symptomatology in up to a third of individuals hospitalised with AN. This study highlights the potential utility of multi‐modal assessment including patient interviews, collateral informants, and behavioural observation to circumvent non‐endorsement.
Influence of slug flow on sand dune transport in a 3.6° upward inclined pipeline
Authors: Goharzadeh Afshin , Nossair Ahmed , Rodgers Peter , Chai John 
Published: March 2024

AbstractThis study presents an experimental investigation of sand conveying from a stationary flatbed through two‐phase liquid–gas flows as a function of the fluids flow rates and pipeline orientation (α = 0°, andα = +3.6°). The characteristics of sand particle transportation by saltation, sand dune formation process and morphologies are visualized using a transparent cylindrical acrylic pipeline and digital photography. It was observed that slug flow regime was the dominant mechanism to lift the sand particles for both horizontal and upward inclinations. It was also found that sand dunes deconstructed more quickly at an upward inclination than horizontal position. For the upward inclination, the conveying phenomenon is characterized by sand bed lifting, suspension, and backward entrainment below the air bubble in the water film. Due to the increased liquid flow rates, higher dune velocity is recorded for the inclined condition. The dune pitch length grew for the horizontal configuration after the transient phase, as a result of the gravitational force effect, while it remained constant for the inclined orientation. In both conditions the slip face angle decreased with time; however, for the inclined configuration, this angle was lower because of the higher upstream liquid flow rate. These results provide important insights into the effect of pipe inclination on bed‐load mode solid transport by two‐phase flow inside a closed circular conduit. The obtained experimental data can be used to validate future numerical investigations.
Fear, gratitude, and the normalization of obstetric violence in Cuban maternity hospitals
Authors: Bastian Hope 
Published: March 2024

AbstractObstetric violence is endemic in Cuba, a highly medicalized society where the obstetrics institution is unquestioned and, in the afterlives of Atlantic slavery and US occupation and intervention, emotions of fear and gratitude work to normalize obstetric violence and control birthing bodies for the state. I draw on ethnographic observations, birth stories, and experiences as a patient to examine how birthing people, providers, and the Revolutionary state negotiate care and responsibility for health. I describe three fears: the fear of failure to protect maternal‐infant health (and its repercussions for clinicians and the state); the fear of physiological childbirth; and fears of inadequate or violent care. Obstetric violence in Cuba is structural. As birthing people shift between primary and tertiary healthcare infrastructures with distinct epistemologies of care, they exert ambiguous agency to domesticate the hostile space of the hospital, building relations of reciprocity and performing docility and compliance. Finally, I look at the gratitude expected of patients and the consequences of refusing to recognize healthcare as a “gift.” This contemporary account of obstetric violence in Cuba contributes to calls by abolition feminists to study the obstetric institution in order to refuse and dismantle it, building life‐affirming futures for maternity care worldwide.