bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adenocarcinoma of the sigmoid colon: Sites of initial dissemination and clinical patterns of recurrence following surgery alone
Authors: Dawson Lynne E. , Russell Anthony H. , Tong Daphne , Wisbeck William M. 
Published: February 2007

AbstractThree hundred and fifty‐five patients with primary adenocarcinoma of the sigmoid colon were retrospectively reviewed. One hundred and eighteen patients who had disseminated disease at diagnosis were analyzed to identify sites and mechanisms of disease spread. Two hundred and thirty‐seven patients treated by surgery alone with curative intent were analyzed to determine clinical patterns of recurrence and identify prognostic factors. Operative findings in 27 patients undergoing second laparotomy at the time of initial disease recurrence are described, and implications for adjuvant therapy discussed.
Cavernous hemangioma of the adrenal gland
Authors: Orringer Robert D. , Lynch John A. , McDermott William V. 
Published: February 2007

AbstractAdrenal hemangiomas are rare tumors that pose difficult diagnostic chal lenges. A report of a giant cavernous hemangioma of the adrenal gland is presented. A review of the literature reveals features of this tumor that aid in understanding its characteristics and facilitate its diagnosis.
Papillary‐cystic carcinoma of the pancreas
Authors: Dales Richard L. , Garcia Juan C. , Davies Ross S. 
Published: February 2007

AbstractPapillary‐cystic carcinoma of the pancreas is an extremely rare tumor which occurs in young adults, may invade locally, but is late to metasta‐size. As opposed to adenocarcinoma of the pancreas, portal vein invasion should not be included as a criteria for nonresectability. In the absence of metastatic disease, pancreatectomy combined with portal vein resection, if invasion is present, may offer a good prognosis and comparatively long survival time.
Determination of axillary nodal status in surgery of breast carcinoma: A prospective study of thirty‐five patients
Authors: Appelqvist P. , Saario I. , Pantzar P. , Lehtola A. 
Published: February 2007

AbstractThirty‐seven axillary status of patients with breast carcinoma was studied with preoperative and peroperative palpation before mastectomy and total axillary dissection. Special attention was paid to the clinical supiciousness and size of axillary nodes. The preoperative axillary palpation gave false diagnosis of axillary content 27% of the time and peroperative, 19%. Of all 249 nodes studied, 54 were found to contain malignant growth in routine histological examination. Mean diameter of malignant nodes was 12.4 mm and of benign nodes, 6.3 mm. The most clinically suspect axillary lymph node gave correct diagnosis of axillary status in 72 % of the cases. The 2 most suspect lymph nodes together were positive in 89%. There was no case with histologically positive axilla where none of the 3 most suspect lymph nodes was malignant. We conclude that at least the 3 most suspect axillary lymph nodes must be removed for histological examination to be sure that axillary metastasizing of breast carcinoma can be found by routine histological examination.
Characterization of the preformed antibodies involved in the xenograft reaction
Authors: Cameron Deborah J. , Rajagopalan P. R. , Fitts C. Thomas , Majeski J. A. 
Published: February 2007

AbstractThe dog‐to‐sheep renal xenograft model was utilized to isolate the antibodies that participate in xenograft hyperacute rejection. These sheep antibodies, which were isolated from the rejected dog kidney, agglutinated and killed only dog blood and kidney cells whereas the whole sheep serum reacted with both dog and rabbit cells. The purified antibody was also utilized to obtain in pure form the antigens involved in the hyperacute rejection. When this antigen was tested for its ability to bind the serum of various species, this particular antigen was highly specific for sheep serum and would not react with rabbit, horse, calf, or mouse sera.
Influence of hepatic artery ligation on liver tumor growth in rats
Authors: Carlsson Goran , Hafström Larsolof 
Published: February 2007

AbstractLiver tumors, both primary and secondary, receive their main blood supply from the hepatic artery. Hepatic artery ligation (HAL) causes a reduction in tumor growth and tumor necrosis. In this experiment, three different experimental tumors were used to study the effect of hepatic artery ligation at different intervals after the occlusion of the arterial blood supply. Hepatic artery ligation causes a reduction in liver tumor growth for all three tumors but with some variation according to age and type of tumor.
The effect of pregnancy on hormone levels and receptors in malignant melanoma
Authors: Sutherland Carl M. , Wittliff James L. , Fuchs Axel , Mabie William C. 
Published: February 2007

AbstractAs previous studies indicate, some cases of malignant melanoma are clearly hormonally dependent as demonstrated by their stimulation by pregnancy and regression following delivery. A case of melanoma initiated during pregnancy and stimulated by a subsequent pregnancy was studied with biochemical receptor studies before and after endocrine manipulation. The negative steriod receptor studies obtained late in the patient's disease at time of endocrine manipulation predicted the lack of response. Results of this study indicate investigations are needed to define the relationship between malignant melanoma and pregnancy.
Serum copper in carcinoma of cervix uteri as an indicator of successful radiotherapy
Authors: Birdi Ashwi , Gupta Saroj , Cambhir S. S. 
Published: February 2007

AbstractSerum copper levels (SCL) have been done in 106 patients of squamous cell carcinoma of the cervix and in 15 cases of local recurrences. The mean SCL has been significantly elevated in them in comparison to controls (P < 0.001). The SCL falls to near normal range following successful therapy. There is a trend to elevation in SCL as the disease progresses. Mean SCL is unrelated to the various morphologic types of squamous cell carcinoma. SCL when compared with clinical radiation response (CRR) show that good CRR has highest mean difference of pre and posttreatment value in comparison to moderate and poor CRR. It appears that highest SCL is associated with advanced disease and poorest prognosis. The estimation of SCL can be used as a check parameter of recurrence and as a prognostic tool in the management of carcinoma of the cervix uteri.
Nonsteroid antiinflammatory drugs and tamoxifen for desmoid tumors and carcinoma of the stomach
Authors: Waddell William R. , Cerner Robert E. , Reich Marshall P. 
Published: February 2007

AbstractThe results of treatment of desmoid tumor patients with nonsteroid antiinflammatory drugs alone or in combination with tamoxifen are described. Tumor growth was inhibited in six of seven patients. Nonsteroid antiinflammatory drugs administered along with 5‐fluorouracil and cyclophosphamide and other inhibitors of T‐suppressor cells were used to treat nine patients with metastatic carcinoma of the stomach. Survival of these patients was extended so that after 12 months minimal follow‐up the majority are well. A prospective controlled clinical trial is indicated.
The role of the regional lymph node in breast cancer: A comparison between nodal and systemic reactivity
Authors: Reiss Craig K. , Volenec F. J. , Humphrey Mark , Singla Om , Humphrey Loren J. 
Published: February 2007

AbstractConfusion remains concerning the role of the regional lymph node in the containment of cancer. Numerous investigators using a variety of assays have reported often conflicting results concerning the immunocompetency of lymphocytes residing in regional nodes. Forty‐two axillary lymph nodes from ten stage I and stage II breast cancer patients were studied in lymphocyte blast assays using mitogens and breast cancer antigen (BCA). Three general response patterns to BCA were identified which were related primarily to tumor size. In the patients with the smallest primary tumor (0.5 cm), lymphocytes in the nodes reacted to a much greater extent than peripheral blood lymphocytes (PBL). In two of three patients with intermediate‐size tumor (1.0 to 1.5 cm), a mixed pattern of responses was seen with both stimulation suppression occurring within the nodes of the same patient. In the four patients with the largest tumors (2.0 to 3.0 cm), 15 of 19 nodes had a lower stimulation index (SI) than the corresponding PBL. From the results of this study it appears that regional lymph nodes are dynamic immunologic structures which regress in responsiveness as tumor burden increases.
Usefulness of preoperative CEA levels in the assessment of colorectal cancer patient stage
Authors: Midiri C. , Amanti C. , Consorti F. , Benedetti M. , Buono S. Del , Tondo U. Di , Castagna G. , Peronace L. , Paola M. Di 
Published: February 2007

AbstractIn order to demonstrate a prognostic value of preoperative CEA levels, we have tried to define a correlation between CEA and histologie stage of tumor in 124 patients with colorectal carcinoma. CEA concentration has been evaluated by radioimmunologic assay and the histologie stage following Dukes' classification. The results show a 25.0% positivity rate for patients in stage A, 48.2% for stage B, 61.1% for stage C, and 85.7% for stage D. The mean CEA values are 7.8 ng/ml in the first group, 30.3 ng/ml in the second, 58.1 ng/ml in the third, and 134.3 ng/ml in the last group. Furthermore, we have tried to relate the histhopathologic grade of the tumor (G) with CEA levels in 54 patients of the 124. We conclude that preoperative CEA has a prognostic value, and it is useful in the staging of colorectal cancer patients. A low concentration indicates an early stage of the tumor, while a high concentration indicates a wide spread of disease; on the other hand, there are not significant correlations with cancer grading.
Primary anorectal malignant melanoma
Authors: Angerås Ulf , Jonsson Nils , Jonsson Per‐Ebbe 
Published: February 2007

AbstractEleven patients with primary anorectal melanoma were analyzed retrospectively. Clinical symptoms and signs were rather unspecific; bleeding in nine, a palpable mass in five, and local pain in three patients. Two patients had the tumor diagnosed accidentally. In all patients the primary tumor was in an advanced stage. A summary of the histopathological characteristics is given in all patients. Six patients were subjected to abdominal perineal resection, four to local excision, and one to a colostomy followed by radiotherapy. All patients developed metastatic disease after a median time of 10 months. The median survival time was 14 months after both abdominal perineal resection and local excision. One patient is still alive after 11 years. Pertinent data form the literature are given.
Renal cell carcinoma presenting as acute pancreatitis and GI bleeding
Authors: Klausner Joseph M. , Rozin Roland R. , Lelcuck Shlomo , Ilie Bianka 
Published: February 2007

AbstractA 75‐year‐old woman was admitted for acute pancreatitis, jaundice, GI bleeding, and a tender mass in the right hypochondrium. Upper gastrointestinal series demonstrated a diverticulum‐like structure on the lateral aspect of the second part of the duodenum. This structure was excised and turned out to be a renal cell carcinoma invading the duodenum by direct extension from the right kidney. Although renal cell carcinoma may present in numerous and often perplexing manifestations, this is a unique presentation.
The effects of cholestyramine, colestipol, and ADR‐132 on the rat prostate and dunning R‐3327 adenocarcinoma
Authors: Brown William J. , Karr James P. , McGarry Michael , Williams Phyllis D. , Hagerman Larry M. , Murphy Gerald P. 
Published: February 2007

AbstractThe effects of three compounds known to have hypocholesterolemic activity in several species were investigated on the rat prostate and the hormone‐dependent R‐3327 rat prostatic adenocarcinoma. Cholestyramine, colestipol, and ADR‐132 are bile acid‐sequestering anion exchange resins which were fed to separate groups of adult male Copenhagen × Fischer (F1) hybrid rats in doses of 0.25%, 1.00%, and 2.00% of diet. The results indicate that serum cholesterol levels in tumor‐bearing rats and controls fed these compounds for 29 days were not reduced. The body and organ weights as well as the histological features of the prostate gland, seminal vesicles, and the R‐3327 tumor were unaffected by these agents.
Complications of ectopic ureterocele in adult female
Authors: Ajrawat H. S. , Imahori S. C. , Magoss I. V. 
Published: February 2007

AbstractThree examples of ectopic ureterocele in adult female were presented. Of these three patients, two had unusual complications: one with a ureterovaginal fistula and the other with neoplastic transformation. Pathologic changes varied from squamous and glandular metaplasia to adenocarcinoma.
Experimental study on merits and demerits of splenectomy in tumor bearers
Authors: Saji Shigetoyo , Oshita Hiroo , Yamamoto Satoru , Takekoshi Tomoharu , Sakata Kazuki 
Published: February 2007

AbstractImmunologic merits and demerits of splenectomy were studied using a rat's experimental tumor. When splenectomy was done on day — 14, 2, or 14 of tumor inoculation, subsequent tumor growth was inhibited, but when it was done on day 7, tumor enhancement was observed. On day 2, cpm values of phytohemagglutinin (PHA)‐induced blastogenesis of splenocytes was lower than in normal rats, on day 7 they significantly increased as compared with day 2, and on day 14 they significantly decreased as compared with day 7. Stimulation index (SI) ratio of PHA‐induced blastogenesis and natural cell‐mediated killing (NK) activity were also investigated using splenocytes, thymocytes, and peripheral lymphocytes. The results indicated that immunological competency of splenocytes of tumor bearers was reduced in the early, late, and final tumor‐bearing periods, while it was increased in the middle tumor‐bearing period. Tumor growth following splenectomy was considered to be controlled by these changes in immunological competency of splenocytes.
Adenocarcinoma of Meckel's diverticulum
Authors: Chen Karl T. K. , Workman Ronald D. , Kirkegaard Dale D. 
Published: February 2007

AbstractThe clinicopathologic features of a case of adenocarcinoma arising in Meckel's diverticulum are described and compared with the 21 cases reported in the literature. The prognosis is generally poor. However, the patient in the present case was alive and well 1.5 years after diagnosis, despite the fact that the lesion had perforated at initial presentation.
Computed tomography and radiotherapy in the treatment of cancer
Authors: Jose B. , Chu Ann M. , Sharma Subhash C. , Tobin Daniel A. , Scott Ralph M. 
Published: February 2007

AbstractComputed tomography (CT) has shown to be of great value in the treatment of cancer with radiation therapy. It is used more and more in the estimation of tumor volume and for treatment planning, with the aid of the computerized treatment unit. At the James Graham Brown Cancer Center, Department of Radiation Oncology, CT has been used routinely for the treatment planning. From October 1, 1981 to June 30, 1982, we performed 180 CT scans for the treatment planning, 380 simple dose calculations, 237 complex treatment plans, and 42 intracavitary dosimetry using the treatment planning unit. This is a review of our experience with some illustrations. Accurate tumor dose can be delivered with reducing the complications with the use of CT and the computerized treatment unit.
Chondrosarcoma of the first metatarsal
Authors: Wiss Donald A. 
Published: February 2007

AbstractChondrosarcoma of the first metatarsal was observed in an 84‐year‐old man. Chondrosarcoma of the small bones of the foot is comparatively rare. These tumors generally arise de novo rather than from a preexisting benign cartilage lesion. Pedal chondrosarcoma presents as a painful enlarging mass. Radiographs show lytic destruction of bone with or without calcification. The histological grade, location of the tumor, and adequacy of surgical excision are the major determinants of long‐term survival.
Adjuvant immunotherapy with BCG in stage II malignant melanoma
Authors: Byrne M. J. , van Hazel G. , Reynolds P. M. , Lemish W. M. , Holman C. D. J. 
Published: February 2007

AbstractForty‐one patients were treated with BCG immunotherapy following block dissection of lymph nodes involved with malignant melanoma. A control group of similar patients who received no immunotherapy was drawn from a population consisting of all patients with malignant melanoma diagnosed in Western Australia in the period from January 1, 1975 to December 31, 1976. The disease‐free survival and overall survival of BCG‐treated patients were not different from that of the control group, who received no immunotherapy. The findings do not support the use of this type of immunotherapy as an adjuvant to surgery in the treatment of patients with stage II malignant melanoma.
The role of fibrin adhesive in vascular surgery
Authors: Ikossi‐O'Connor M. G. , Ambrus J. L. , Rao Uma 
Published: February 2007

AbstractFibrin Seal (FS) (a natural adhesive material composed of fibrinogen, cold insoluble globulin, factor XIII, platelet growth factor, antiplasmin thrombin, and calcium chloride) was utilized in the construction of vascular anastomosis of the femoral artery of mongrel dogs. A significant decrease in the number of sutures necessary to achieve adequate anastomosis and minimize the likelihood of postoperative bleeding was noted. There was no long‐term increase in tissue reaction or decrease in arterial patency.On the basis of these preliminary results the role of FS as a hemostatic agent in vascular and especially microvascular surgery warrants further investigation.
Noninvasive cardiac evaluation of patients receiving adriamycin‐containing adjuvant chemotherapy (FAC) for stage II or III breast cancer
Authors: Ali M. Khalil , Buzdar Aman U. , Ewer Michael S. , Cheng Renalto S. , Haynie Thomas P. 
Published: February 2007

AbstractCardiac function was evaluated by noninvasive methods in 55 patients with stage II or III breast cancer treated with adjuvant Adriamycin containing combination chemotherapy (FAC). None of the 44 patients who remained free of disease for a median follow‐up period of 36 months, or those who were retreated with Adriamycin up to a median cumulative total dose of 450 mg/m2 (nine patients), developed clinical evidence of cardiac decompensation. The median electrocardiographic QRS voltage and ejection fraction decreased by 11% and 5%, respectively, in the former and by 21% and 10% in the latter group at the conclusion of chemotherapy. These parameters tended to return to the baseline at the time of the last visit. The decreases in QRS voltage and ejection fraction were greater in patients who received radiotherapy and had prior cardiovascular disease than in those without such risks. The remaining two patients were retreated with higher total doses of Adriamycin. Both showed clinical evidence of cardiac decompensation and gradual deterioration of the noninvasively measured parameters of cardiac function. One patient was alive six months after the discontinuation of Adriamycin at a total dose of 842 mg/m2, and the other died of pulmonary embolism two months after receiving a total of 892 mg/m2.Our study shows that Adriamycin can be included in adjuvant therapy without inducing clinically significant alterations in cardiac function; however, patients who have additional risk factors should be monitored closely with noninvasive studies while they receive this drug.
Ligation and catheterization of the hepatic artery for palliative treatment of malignant hepatic tumors
Authors: Takagi Hiroshi , Morimoto Takeshi , Yasue Mitsunori , Ochiai Eiichi , Yamada Eikichi , Ashizawa Tatsuto , Kido Choichiro 
Published: February 2007

AbstractEleven unresectable hepatoma patients and three metastatic tumor patients with colonic cancer underwent ligation and/or catheterization of the hepatic artery of the main tumor‐bearing zone. Mitomycin C (liquid or microcapsulated) or Adriamycin were administered via the catheter intermittently or continuously with a portable pump device. In follow‐up study the tumor size was frequently visualized by arteriography via the cannula. Some tumors became smaller with calcification. The levels of α‐Fetopro‐tein of CEA in some cases dropped remarkably and stayed low for a fairly long period. There was no immediate postoperative death. Six of 11 unresectable hepatoma patients survived longer than 8 months with a maximum survival of 17.5 months. Two of three metastatic patients have survived more than 11 months at this writing. This method seems effective for prolongation of patient survival.
Humoral response of melanoma patients to two different tumor‐associated antigens
Authors: Chee Darwin O. , Gupta Rishab K. , Morton Donald L. 
Published: February 2007

AbstractSera of 8 stage II melanoma patients undergoing surgical adjunctive immunotherapy with bacille Calmette Guérin (BCG) plus melanoma cell vaccine (MCV) were assayed for humoral response by the complementdependent antibody cytotoxicity (CDAC) assay and by the microcomplement fixation (MCF) test. The patients developed high levels of cytotoxic (CTX) and complement‐fixing (CF) antibodies to the UCLA‐SO‐M14 (M14) cells, one of the three melanoma cell lines in the MCV. Significant rises in CTX and CF antibodies occurred one month post‐immunotherapy. While the level of CTX antibodies was maintained for 11 months thereafter, the titer of CF antibodies was sustained for seven months, then gradually declined. When the sera were absorbed with lymphoblastoid (ML14) cells which are autologous to the M14 cells, two residual peaks of CTX antibodies, one and four months postimmunotherapy and two peaks of CF antibodies, one and seven months postimmunotherapy, emerged. Two sera that exhibited high levels of CTX and CF antibodies one month postimmunotherapy were absorbed with ML 14 cells and human fetal brain tissue. The reactivity of one serum in both the CDAC and MCF assays was abolished, whereas the reactivity of the other serum was not significantly diminished in either assay. These data indicate that the stage II post‐surgical melanoma patients developed a humoral immune response to at least two distinct tumor antigens on the membrane of the M14 cells. One of these antigens appeared to be of fetal origin (OFA). the other M14‐associated (TAA). Both antigens, OFA and TAA, were involved in complement‐dependent antibody cytotoxic and complement fixation reactions in vitro.
Postoperative radiation therapy for muscle‐invading bladder carcinoma
Authors: Kopelson Gene , Heaney John A. 
Published: February 2007

AbstractFrom 1974–1980, 15 patients with pT2–4 bladder carcinoma received adjuvant postoperative radiation therapy (XRT). The extent of initial surgery varied (six radical cystectomy, 5 partial cystectomy, four “total” transurethral resection). The planned XRT was 4,000–5,040 rads in 5–6 weeks to the pelvis (achieved in 14/15 patients) followed by a bladder boost in noncystectomized patients (achieved in 8/9). Survival at two years and five years was 54% (7/13 patients) and 27% (3/11 patients), respectively. Local‐regional disease control (minimum two‐year follow‐up) was achieved in 7/11 (63%). Of seven patients alive at least two years later, small bowel complications (chronic diarrhea, obstruction) occurred in two; these latter patients each had had radical cystectomy. Adjuvant postoperative XRT may be useful in the multimodality management of patients with bladder carcinoma, especially those identified as high risk after pathologic staging and initial surgery. The poor regional control rate and relatively high incidence of complications seen in this and previous studies suggest that improved radiation technique is needed, both to ensure adequate coverage of the volume at risk and to minimize complications. Representative portals are shown to illustrate these features.