bluuebunny/crossref_metadata_2025_split huggingface dataset:
Espionage and The Harming of Innocents
Authors: Christie Lars 
Published: March 2024

AbstractIn her latest book Spying Through a Glass Darkly: The Ethics of Espionage and Counter-Intelligence, Cécile Fabre suggests that the deception of third parties during an infiltration operation can be justified as a foreseen but unintended side effect. In this essay, I criticize this view. Such deception, I argue, is better justified paternalistically as a means of preventing third parties from becoming wrongful threats. In the second part of the article, I show that Fabre ignores an important moral complication in deception operations where agents intentionally allow others to be harmed as a means of protecting a secret. I argue that intentionally allowing harm to others as a means is a particularly problematic mode of agency which must be addressed in a normative account of espionage.
Effect of Zusanli Acupoint Injection with Anisodamine on Postoperative Recovery Quality of Patients Undergoing Bariatric Surgery
Authors: Cheng Jianxin , Wang Xiaohan , Wang Rui , Sheng Jingyi , Guo Shanshan , Liu Tianya , Wang Zhiping 
Published: March 2024

Abstract
Purpose
To evaluate the influence of anisodamine injection at the Zusanli (ST36) on early postoperative recovery quality in patients who have undergone laparoscopic sleeve gastrectomy.

Materials and Methods
141 patients undergoing laparoscopic sleeve gastrectomy were randomly divided into the control group (group C), the normal saline group (group S) and the anisodamine group (group A). Acupuncture point injections were administered after induction of general anesthesia. The quality of recovery-40 questionnaire (QoR-40) scores were documented preoperatively (D0) and on the 1st (D1), 3rd (D3) and 7th (D7) days postoperatively. Additional metrics included: the numerical rating scale (NRS) for pain, postoperative nausea and vomiting (PONV), assessment and analgesic consumption 24-h post-extubation and the initial postoperative times for ambulation and anal exhaust. Substance P (SP), β-endorphin (β-EP), motilin (MTL) and gastrin (GAS) were quantified at 24-h post-surgery.

Results
Compared with group C, group A demonstrated an elevation in QoR-40 scores and physical comfort dimensions during D1-3, and an increased pain scores during D1-7; group S exhibited an augmentation in QoR-40 scores and pain scores on D1 (p < 0.05). Compared with group S, group A improved QoR-40 scores on D1 and pain scores during D1-3 (p < 0.05). SP, β-EP, MTL and GAS presented significant variances among the groups 24-h post-surgery (p < 0.05). There were significant differences between the groups in NRS pain scores and PONV scores at 24-h postoperatively, dosage of dizocin on the first postoperative day, and time to first anal defecation (p < 0.05).

Conclusion
The administration of anisodamine via ST36 acupoint injections has been demonstrated to facilitate the recuperation of gastrointestinal functionality, to alleviate postoperative pain and nausea, and substantially to enhance the quality of early postoperative recovery.

Graphical Abstract
Xylazine: A Drug Adulterant of Clinical Concern
Authors: Edinoff Amber N. , Sall Saveen , Upshaw William C. , Spillers Noah J. , Vincik LeighAnn Y. , De Witt Adalyn S. , Murnane Kevin S. , Kaye Adam M. , Kaye Alan D. 
Published: March 2024

AbstractPurpose of ReviewThe opioid epidemic has been responsible for significant morbidity and mortality in the USA and worldwide. As a result, it is essential to recognize the threat these potent drugs can cause when illicitly used. Specifically, introducing fentanyl as a drug adulterant has been shown to impact overdose rates drastically. In this regard, the Drug Enforcement Agency recently released a public safety alert announcing the new threat of a new adulterant called xylazine. Xylazine is a powerful animal sedative with a different mechanism of action when compared to illicit opioids such as heroin and fentanyl. Xylazine is typically injected intravenously via a syringe, often in combination with multiple other drugs. One of the most common drugs, xylazine, is taken in combination with fentanyl, with users of this drug combination describing xylazine as prolonging the euphoric sensation produced by fentanyl.Recent FindingsXylazine may cause adverse effects such as bradycardia, brief hypertension followed by hypotension, premature ventricular contractions, ataxia, slurred speech, sedation, and respiratory depression. Much of the recent literature on xylazine use in humans comes from case reports and review articles.SummaryRelated to widespread use in veterinary medicine and increasing circulation in illicit drug markets, there is a critical need for public awareness and additional clinical-based studies to further increase understanding of mediated or modulated pharmacological effects of xylazine in humans. Further research is urgently needed to more clearly understand the implications of unregulated xylazine in the illicit drug market, to formulate public health interventions, and to implement harm reduction strategies.
Dyslipidemia, lipid-lowering agents and neuroendocrine neoplasms: new horizons
Authors: Modica Roberta , La Salvia Anna , Liccardi Alessia , Cozzolino Alessia , Di Sarno Antonella , Russo Flaminia , Colao Annamaria , Faggiano Antongiulio ,   on behalf of NIKE group
Published: March 2024

Abstract
Purpose
Neuroendocrine neoplasms (NENs) are a heterogeneous group of malignancies originating from cells with a neuroendocrine phenotype. The complex relationship between lipid metabolism and cancer is gaining interest and a potential anti-cancer effect of lipid lowering agents is being considered. This review aims to discuss the current understanding and treatment of dyslipidaemia in NENs, focusing on the role of lipid lowering agents, including new therapeutic approaches, and future perspectives as possible tool in cancer prevention and tumor-growth control.

Methods
We performed an electronic-based search using PubMed updated until December 2023, summarizing the available evidence both in basic and clinical research about lipid lowering agents in NENs.

Results
Dyslipidemia is an important aspect to be considered in NENs management, although randomized studies specifically addressing this topic are lacking, unlike other cancer types. Available data mainly regard statins, and in vitro studies have demonstrated direct antitumor effects, including antiproliferative effects in some cancers, supporting possible pleiotropic effects also in NENs, but data remain conflicting. Ezetimibe, omega 3-fatty acids, fibrates and inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9) may enhance the regulation of lipid homeostasis, as demonstrated in other cancers.

Conclusions
Targeting dyslipidemia in NENs should be part of the multidisciplinary management and an integrated approach may be the best option for both metabolic and tumor control. Whether lipid lowering agents may directly contribute to tumor control remains to be confirmed with specific studies, focusing on association with other metabolic risk, disease stage and primary site.
Partial validation of a six-month high-fat diet and fructose-glucose drink combination as a mouse model of nonalcoholic fatty liver disease
Authors: Makri Evangelia S. , Xanthopoulos Konstantinos , Mavrommatis Parasidis Panagiotis , Makri Eleftheria , Pettas Spyros , Tsingotjidou Anastasia , Cheva Angeliki , Ballaouri Iris , Gerou Spyridon , Goulas Antonis , Polyzos Stergios A. 
Published: March 2024

Abstract
Purpose
The need to investigate the pathogenesis and treatment of nonalcoholic fatty liver disease (NAFLD) has led to the development of multiple mouse models. The aim of this study was to validate a fast food diet (FFD) mouse model that is introduced as being close to the human disease.

Methods
Eight to nine weeks old male and female C57BL/6 J mice were randomly allocated to a FFD group or to a chow diet (CD) group. Every four weeks, mice were weighed, and blood samples were collected for the measurement of glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglycerides (TGs) and total cholesterol. After 25 weeks, mice were sacrificed, and liver tissue was histologically evaluated.

Results
FFD mice gained more weight (p = 0.049) and presented a higher liver-to-body weight ratio (p < 0.001) compared to CD mice. FFD group presented with greater steatosis, hepatocellular ballooning and NAFLD activity score (NAS), whereas lobular inflammation and fibrosis were not significantly different compared to CD. When stratified by sex, NAS was different between FFD and CD groups in both male and female mice. Group by time interaction was significant for weight, ALT and cholesterol, but not for glucose, AST and TGs.

Conclusion
FFD mice presented with morphologic and biochemical features of NAFLD and with greater hepatic steatosis, hepatocellular ballooning and NAS, but not lobular inflammation and fibrosis, compared to CD mice. These results only partly validate the FFD mouse model for NAFLD, at least for a 6-month feeding period.
The potential of soil microbial communities to transform deoxynivalenol in agricultural soils—a soil microcosm study
Authors: Kenngott Kilian G. J. , Muñoz Katherine 
Published: March 2024

AbstractInfestation of cereal fields with toxigenic Fusarium species is identified as an environmental source for the mycotoxin deoxynivalenol (DON). During rain events, DON may be washed off from infested plants and enter the soil, where microbial transformation may occur. Although some studies showed DON transformation potential of soil microbial communities in liquid soil extracts, these findings can not be transferred to environmental conditions. Accordingly, microbial transformation of DON in soil has to be investigated under realistic conditions, e.g., microcosms mimicking field situations. In this study, we investigated the potential of soil microbial communities to transform DON in six different agricultural soils at two levels (0.5 and 5 µg g–1). The dissipation and the formation of transformation products were investigated in a period of 35 days and compared to a sterilized control. In addition, we measured soil respiration and applied the phospholipid-derived fatty acid (PLFA) analysis to assess whether soil microbial community characteristics are related to the microbial transformation potential. Dissipation of DON in non-sterilized soils was fast (50% dissipation within 0.6–3.7 days) compared to the sterile control where almost no dissipation was observed. Thus, dissipation was mainly attributed to microbial transformation. We verified that small amounts of DON are transformed to 3-keto-deoxynivalenol (3-keto-DON) and 3-epi-deoxynivalenol (3-epi-DON), which were not detectable after 16-day incubation, indicating further transformation processes. There was a trend towards faster transformation in soils with active and large microbial communities and low fungi-to-bacteria ratio.
Evaluating the effectiveness of dual dye combination of indocyanine green and carbon nanoparticles with parathyroid hormone test in preserving parathyroid gland during papillary thyroid cancer surgery: a single-center retrospective cohort study
Authors: Chen Yuliang , Zhang Songze , Miao Keyu , Li Jiagen 
Published: March 2024

AbstractPreserving the integrity of parathyroid glands is crucial in papillary thyroid cancer (PTC) surgery to avoid hypoparathyroidism. In recent years, two novel dyes, activated carbon nanoparticles (CNP) and indocyanine green (ICG), have been utilized to assist in parathyroid gland identification. However, the use of CNP or ICG alone can result in extravasation of dye or excessive fluorescence of non-parathyroid tissue, which can affect the accuracy of surgical outcomes by yielding false negative or false positive results. Therefore, it is important to further optimize the application of these two dyes in surgery. We analyzed case files of 124 PTC patients who underwent routine total or near-total thyroidectomy with bilateral lymph node dissection in the central region at the Affiliated People's Hospital of Ningbo University from January to November 2022. The patients were randomly divided into three groups based on the type of intraoperative dye used. The CNP group (n = 38) received an intra-thyroidal injection of CNP dye. The ICG group (n = 42) used the ICG near-infrared fluorescence endoscopy system to show parathyroid fluorescence. The group that received a combined approach of ICG and CNP (n = 44) leveraged the advantages of both methods that allow for positive development of ICG and negative development of CNP to identify and preserve the parathyroid gland during operation. The parathyroid hormone detection reagent (PTH test method) was employed to verify the highly suspected parathyroid tissue in all three groups. We analyzed intraoperative data pertaining to intraoperative parathyroid identification, misexcision, number of autotransplantation, and postoperative hypoparathyroidism among the three groups. Compared with the ICG group and the CNP group, the combined group demonstrated more prominent advantages in identifying average the number of lower parathyroid glands (1.93 ± 0.26, p = 0.015), reducing the average numberrate of misexcision (0.45 ± 0.5, p = 0.004), and reducing the incidence of postoperative temporary hypothyroidism (3/44, p = 0.015). The combined use of ICG and CNP dual-dye with PTH test method appears to be more effective in both identifying and protecting parathyroid glands during PTC surgery.
Spatiotemporal variation of land surface temperature and its driving factors in Xinjiang, China
Authors: Zhang Mingyu , Cao Yu , Zhang Zhengyong , Zhang Xueying , Liu Lin , Chen Hongjin , Gao Yu , Yu Fengchen , Liu Xinyi 
Published: March 2024

AbstractLand surface temperature (LST) directly affects the energy balance of terrestrial surface systems and impacts regional resources, ecosystem evolution, and ecosystem structures. Xinjiang Uygur Autonomous Region is located at the arid Northwest China and is extremely sensitive to climate change. There is an urgent need to understand the distribution patterns of LST in this area and quantitatively measure the nature and intensity of the impacts of the major driving factors from a spatial perspective, as well as elucidate the formation mechanisms. In this study, we used the MOD11C3 LST product developed on the basis of Moderate Resolution Imaging Spectroradiometer (MODIS) to conduct regression analysis and determine the spatiotemporal variation and differentiation pattern of LST in Xinjiang from 2000 to 2020. We analyzed the driving mechanisms of spatial heterogeneity of LST in Xinjiang and the six geomorphic zones (the Altay Mountains, Junggar Basin, Tianshan Mountains, Tarim Basin, Turpan-Hami (Tuha) Basin, and Pakakuna Mountain Group) using geographical detector (Geodetector) and geographically weighted regression (GWR) models. The warming rate of LST in Xinjiang during the study period was 0.24°C/10a, and the spatial distribution pattern of LST had obvious topographic imprints, with 87.20% of the warming zone located in the Gobi desert and areas with frequent human activities, and the cooling zone mainly located in the mountainous areas. The seasonal LST in Xinjiang was at a cooling rate of 0.09°C/10a in autumn, and showed a warming trend in other seasons. Digital elevation model (DEM), latitude, wind speed, precipitation, normalized difference vegetation index (NDVI), and sunshine duration in the single-factor and interactive detections were the key factors driving the LST changes. The direction and intensity of each major driving factor on the spatial variations of LST in the study area were heterogeneous. The negative feedback effect of DEM on the spatial differentiation of LST was the strongest. Lower latitudes, lower vegetation coverage, lower levels of precipitation, and longer sunshine duration increased LST. Unused land was the main heat source landscape, water body was the most important heat sink landscape, grassland and forest land were the land use and land cover (LULC) types with the most prominent heat sink effect, and there were significant differences in different geomorphic zones due to the influences of their vegetation types, climatic conditions, soil types, and human activities. The findings will help to facilitate sustainable climate change management, analyze local climate and environmental patterns, and improve land management strategies in Xinjiang and other arid areas.
Zoonotic Parasites in Reptiles, with Particular Emphasis on Potential Zoonoses in Australian Reptiles
Authors: Leung Tommy L. F. 
Published: March 2024

Abstract
Purpose of Review
Zoonotic infections are a major public health issue, but reptiles are generally overlooked as sources of zoonoses compared with other classes of vertebrate animals. This paper provides an overview of the biology and ecologies of zoonotic parasites, including helminths, arthropods and protozoans from reptiles.

Recent Findings
Reptile zoonoses include parasites from a wide range of taxa, and a variety of different infection routes. In particular, Australia’s diverse reptile fauna may be harbouring a range of parasites with varying degrees of zoonotic potential, but the basic biology and ecology of many of those parasites are poorly known.

Summary
While some reptile parasites are foodborne zoonoses, many others may be acquired from exposure to infective stages which have been shed into the environment, especially among captive reptiles. Within Australia, consumption of reptile meat is rare in comparison to other parts of the world, but the increasing popularity of reptiles as pets means that captive pets and the reptile trade may become a key source of emerging zoonoses in the future.
Curriculum, democracy and pedagogies for justice: a collective futures dialogue
Authors: Maher Katie , Rigney Lester-Irabinna , King Mikayla , Garrett Robyne , Windle Joel , Memon Nadeem , Wrench Alison , Carter Jenni , Paige Kathryn , O’Keeffe Lisa , Lovell Margaret , Schulz Samantha , Soong Hannah , Colton Jill , McDonald Sarah , Hattam Robert 
Published: March 2024

AbstractThis collaborative paper by members of the Pedagogies for Social Justice Research Group responds to the question of how curriculum and pedagogy can be with and for democracy. Our introduction takes Alice Rigney’s and Dewey’s insights on education and democracy as our point of departure for learning together. As a collective, we have gathered together multiple ways of perceiving and enacting a curriculum for democracy in a context of de-democratisation. We approach tensions, intersections, limits and possibilities of curriculum and democracy from the frames of ‘woven’ curriculum and critical Indigenous pedagogies; racially, religiously and culturally responsive pedagogies; dialogic and relational approaches; agentic, embodied, activist and rights-based pedagogies; and everyday praxis.Kalkadoon scholar Mikayla King’s opening paper on the woven curriculum provides both a point of departure and a grounding site for weaving together our collaborative insights into curriculum, democracy and pedagogies for justice. Garrett and Windle draw attention to how affective and embodied pedagogies can challenge mind/body binaries and activate rights-based modes of being and learning. Memon observes how religion shapes the lifeworlds of learners and proposes a move towards learning from religion. Wrench, Carter, Paige and O’Keeffe advocate for the embedding of eco-justice principles, sociologically informed curriculum, and culturally responsive and story-sharing pedagogies. Lovell and Schulz claim racial literacy as an essential component of a pluralistic democracy that honours First Nations’ sovereignty. Soong suggests that ‘everyday pedagogy’ might enable educators to relate with pre-service teachers as critical and empathetic humanists beyond the role of neoliberalised technicians. Colton and McDonald highlight possibilities within the curriculum for learners to act with the pluralities of the world. McDonald and Schulz argue that gender equity is a necessary foundation for a peaceful, democratic world. We conclude with Hattam’s reiteration of how schooling as a key site for social formation re-produces the nation. He urges us to defy the monologue of authoritarian governing and ‘live together through dialogue’.
Challenging pre-service teacher habitus: A self-study of unit design in teacher education
Authors: Williams John , Ovens Alan 
Published: March 2024

AbstractThe purpose of our paper was to examine how John, the lead author, attempted to bridge the reality-congruence gap between how his Health and Physical Education (HPE) pre-service teachers (PSTs) knew HPE, before commencing the undergraduate unit (subject) central to this paper and how we know contemporary HPE as teacher educators. Here we use reality congruence according to its figurational sociology meaning as “the knowledge of it that is possible” (Giovannini, 2015, n.p.). The “it that is possible,” is the broad disciplinary knowledge necessary for teaching HPE contemporarily, that both authors have acquired over many years. A self-study approach was adopted, using Norbert Elias’s figurational sociology to deductively analyse John’s practice in teaching the reported unit. We used a two-phase approach, with phase one being an exploration of John’s experience of unit design and phase 2 examining John’s assumptions about his practice and his students. We found that John’s approaches were effective in influencing his students to learn and value reality-congruent HPE. Supporting qualitative student satisfaction data suggested many HPE-PSTs valued the teaching approaches John used, which also aligned with their learning preferences. Through planning teacher education curriculum content that challenges traditional notions of PE in particular, it is possible for teacher educators to influence HPE-PSTs towards learning and embracing more reality congruent HPE.
On-ground validation of orbital GNC: Visual navigation assessment in robotic testbed facility
Authors: Muralidharan Vivek , Makhdoomi Mohatashem Reyaz , Žinys Augustinas , Razgus Bronislovas , Klimavičius Marius , Olivares-Mendez Miguel , Martinez Carol 
Published: March 2024

AbstractCubeSats have become versatile platforms for various space missions (e.g., on-orbit servicing and debris removal) owing to their low cost and flexibility. Many space tasks involve proximity operations that require precise guidance, navigation, and control (GNC) algorithms. Vision-based navigation is attracting interest for such operations. However, extreme lighting conditions in space challenge optical techniques. The on-ground validation of such navigation systems for orbital GNC becomes crucial to ensure their reliability during space operations. These systems undergo rigorous testing within their anticipated operational parameters, including the exploration of potential edge cases. The ability of GNC algorithms to function effectively under extreme space conditions that exceed anticipated scenarios is crucial, particularly in space missions where the scope of errors is negligible. This paper presents the ground validation of a GNC algorithm designed for autonomous satellite rendezvous by leveraging hardware-in-the-loop experiments. This study focuses on two key areas. First, the rationale underlying the augmentation of the robot workspace (six-degree-of-freedom UR10e robot + linear rail) is investigated to emulate relatively longer trajectories with complete position and orientation states. Second, the control algorithm is assessed in response to uncertain pose observations from a vision-based navigation system. The results indicate increased control costs with uncertain navigation and exemplify the importance of on-ground testing for system validation before launch, particularly in extreme cases that are typically difficult to assess using software-based testing.