bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary mucinous adenocarcinoma of the trachea: The case for complete surgical resection
Authors: Reed Donald N. , Hassan Abdul A. , Wilson Robert F. 
Published: February 2007

AbstractAdenocarcinomas of the trachea are rare but important because the only reported treatment in the past (radiation) has resulted in uniformly poor results. The authors recently had the opportunity to treat a young woman with a mucin‐producing adenocarcinoma of the trachea. A sleeve resection of the involved trachea with reanastomosis was successful, and the patient is alive and well with no evidence of tumor four years later. Thus, primary resection should be strongly considered for adenocarcinoma of the trachea whenever possible.
Priapism as the presenting feature of renal cell carcinoma
Authors: Sarma Deba P. , Woods Abraham L. , Rodriguez Fred H. , Mendoza Julian , Weilbaecher Thomas G. 
Published: February 2007

AbstractWe describe a case of renal cell carcinoma with metastasis to the penis clinically presenting with priapism. Six such cases found in the literature are reviewed. Neoplastic disease is far advanced in these cases and therapy is only palliative.
Bladder and urethral dysfunction after radical abdominal hysterectomy: Rehabilitative treatment
Authors: Zanolla R. , Monzeglio C. , Campo B. , Ordesi G. , Balzarini A. , Martino G. 
Published: February 2007

AbstractWe studied bladder and urethral function prospectively in 64 patients before and after Wertheim's radical hysterectomy. Immediately after surgery, neurogenic bladder dsyfunction of various degrees was found in 70% of all patients who presented difficulty of voiding, with high residual urine and/or stress incontinence. All the patients have received an early rehabilitative treatment with kinesitherapy and/or pharmacological therapy after the bladder catheter removal and the urodynamics' results. We have obtained a satisfactory functional recovery of the bladder activity in 91% of the symptomatic patients.
A new 111in‐bleomycin complex for combined radiotherapy and chemotherapy
Authors: Hou De‐Yan , Hoch Hans , Johnston Gerald S. , Tsou K. C. , Jones Alfred E. , Farkas Raymond J. , Miller Elizabeth E. , Larson Steven M. 
Published: February 2007

AbstractSix days after tumor transplantation three daily intraperitoneal doses of 0.9% NaCl, bleomycin (BLM), or a new 111In‐bleomycin complex (BLMC, 15 μCi/g body weight) were administered to glioma‐bearing mice. After therapy, tumors in mice treated with 111In‐BLMC were smaller than those treated with BLM. Sixteen days after the first injection tumor size for 111In‐BLMC‐treated mice was 560 (240–1,030) mm3, 1,980 (1,400–3,290) mm3 for BLM (P < 0.025), and 4,830 (2,580–9, 180) mm3 for NaCl (0.1 < P < 0.2).Thirteen days after tumor transplantation glioma‐bearing mice received single intratumor injection of 0.9% NaCl, BLM, or 111In‐BLMC (1.5 mCi, carried by 0.5 mg BLM/g tumor weight). The average tumor size for 111In‐BLMC was smaller than that for BLM by a factor of 2.5–3.7. Host weights for these two groups were similar, and morphologic abnormalities were not found in kidney or liver.
Neoplasms in skin and subcutis over the breast, simulating breast neoplasms: Case reports and literature review
Authors: Ilie Bianca 
Published: February 2007

AbstractTwenty cases of neoplasms in skin and subcutaneous tissue over the breast were reviewed. There were 17 women, from 15 to 70 years of age, and three men, from 25 to 66 years of age. Among the benign skin neoplasms, superficial leiomyoma, granular cell tumor, and eccrine acrospiroma were misdiagnosed clinically as primary breast carcinoma.Among the malignant neoplasms in subcutaneous tissue, there were three metastatic malignant melanomas, one metastatic epidermoid bronchogenic carcinoma, and two malignant lymphomas. It is interesting that four of these six patients had no prior history of malignant lesion, the subcutaneous nodule presenting as the first manifestation of an occult primary. It is concluded that histological diagnosis of such tumors may lead to avoidance of unnecessary radical surgery.
Endobronchial metastases from soft tissue sarcoma
Authors: Udelsman Robert , Roth Jack A. , Pass Harvey I. , Lees David , Jelenich Sandra E. 
Published: February 2007

AbstractThe majority of patients with pulmonary metastases from primary soft tissue sarcomas have peripheral lesions that can be removed by wedge excision. A subset of these patients, however, present with, or develop, clinically significant endobronchial metastases. These patients require a preoperative evaluation that includes pulmonary function testing and a detailed endoscopic evaluation of the bronchial tree. We described three of these patients from the National Cancer Institute and review the clinical histories of eight additional previously reported cases.
Duodenal villous adenomas
Authors: Brian Johnny E. , Herring C. Frank , Stair J. Michael 
Published: February 2007

AbstractTwo cases of villous adenoma of the duodenum are presented. These rare tumors are best diagnosed with upper gastrointestinal radiographs and endoscopic biopsy. Malignant degeneration is more common in the second portion of the duodenum which makes excision more difficult. If no malignancy is found, sleeve resection is preferred. Tumors in the second portion of the duodenum should be treated with wide mucosal excision if carcinoma in situ is found and with pancreaticoduodenectomy if invasive cancer is present.
Villous tumors of the duodenum and ampulla of vater
Authors: Celik Cihangir , Venditti Joseph A. , Satchidanand Sateesh , Freier Duane T. 
Published: February 2007

AbstractPolypoid epithelial tumors of the duodenum and ampulla of Vater are rarely diagnosed preoperatively without wide application of fiberoptic endoscopy. The symptoms are nonspecific. Only a high index of suspicion will lead to early diagnosis. Life‐threatening complications and increased incidence of malignant transformations are associated with delayed diagnosis. This paper reviews 11 patients (nine previously unreported) with villous tumor of the ampulla of Vater and two with this neoplasm in the duodenum. It also reviews the important principles of management illustrated by the behavior of the tumors of these 11 patients compared to those of previous reports. For favorable results, all lesions must be excised in toto and evidence of invasive malignancy must lead to aggressive treatment whenever feasible.
The surgeon's future role in the conquest of cancer
Authors: Hutchinson William B. 
Published: February 2007

AbstractThis article is a brief review alluding to the multidisciplinary modalities including bask science technologies that are available in the treatment of today's cancer victim. The roles are discussed of the general surgeon and of the surgical fellow, later a surgical oncologist, as they merge into their respective positions to practice their art. The necessity of limiting the number of surgical oncologists with helpful hints on how they can survive in a nonacademic atmosphere are presented. The multidisciplinary approach to treatment of cancer is stressed.
Carcinoma of the Larynx
Authors: Robertson A. G. , Boyle P. , Deuchars F. , Robertson C. 
Published: February 2007

AbstractSix hundred sixty‐eight patients with tumours of the larynx were treated by radiotherapy. The patients had stage T1 NO MO to T4 N3 MO disease. Patients with T1 NO MO disease (273) had an excellent long‐term survival (90%) as did those with T2 NO MO disease (142), whose 5‐year survival was 70%. Patients with more advanced disease but no nodal spread did not respond as readily to radiotherapy; the 5‐year survival was 40%. All patients were treated using a parallel pair set‐up 6 × 6 cm lateral neck fields. A more aggressive radiotherapy regime to a larger tissue volume to include microscopic spread to lymph nodes may improve survival of locally advanced disease.
Proton NMR of human breast tumors: Correlation with clinical prognostic parameters
Authors: Chu David Z. J. , Yamanashi William S. , Frazer James , Hazlewood Carlton F. , Gallager H. Stephen , Boddie Arthur W. , Martin Richard G. 
Published: February 2007

AbstractProton NMR spectroscopy and imaging of human breast tissue have provided new methods in studying breast carcinomas. Continuous wave proton NMR spectroscopy in this study is able to discriminate breast carcinomas from normal breast tissue on the basis of the integrated area under the water and lipid peaks, width at half height of the water peak, and chemical shift of the lipid peak. In addition, the NMR parameters were correlated with the following clinical and pathologic prognostic indices: TNM tumor stage, nuclear grade, and estrogen receptor status (ER). Width at half height of the lipid peak (1/2Δlipid) correlated with tumor content and ER. Studies using higher resolution proton or phosphorus NMR spectra may separate signals that can correlate with biological information on breast neoplasms useful to the clinician. Chemical shift of the lipid peak may be used to sharpen contrast on MRI of breast tumors.
Surgical approach to malignant melanoma in the gastrointestinal tract
Authors: Gutman M. , Klausner J. M. , Inbar M. , Chaitchik S. , Rozin R. R. 
Published: February 2007

AbstractThe gastrointestinal (GI) tract is a common site for malignant melanoma. Diagnosis of lesions in the GI tract is usually delayed until complications occur, such as obstruction, bleeding, or perforation of the GI tract. Of 348 patients with malignant melanoma treated during a 10‐year period, 11 had GI involvement either in a metastatic form or as a primary melanoma. Three of these patients were treated surgically for metastatic lesions in the small bowel causing intussusception, two for peritonitis secondary to perforation of the small bowel, and one for massive bleeding from metastatic melanoma in the stomach. Another patient had a primary melanoma in the esophagus and underwent esophagectomy. Three patients had primary melanomas of the anal canal and one of the rectum. Three of them underwent abdominoperineal resections, and two had bilateral groin dissection in addition. Six of the patients are alive 6 months to 4 years following diagnosis. The remaining five died of metastatic melanoma from 6 months to 4 years post‐surgery.
Acute upper gastrointestinal bleeding as primary symptom of gastric carcinoma
Authors: Moreno‐Otero R. , Rodriguez S. , Carbo J. , Mearin F. , Pajares J. M. 
Published: February 2007

AbstractLittle information is available regarding acute upper gastrointestinal bleeding as a presenting sign of gastric carcinoma. Of 427 patients with gastric cancer, 36 (8.4%) underwent early endoscopy due to hematemesis. The hemorrhage was self‐limited in 16 patients (44.4%), most of whom underwent elective surgery. Twenty patients (55.6%) had persistent or massive bleeding, and 13 of these underwent early surgery with a surgical mortality of 3 cases (23.1%); the remaining 7 patients were not operated on, and died secondary to the hemorrhage. The total mortality rose to 10 patients (27.7%). The mean age was higher in patients with persistent or massive bleeding, mainly in those who did not undergo surgery and died. We conclude that the immediate outcome is related to age and previous general condition, rather than to the definite diagnosis of gastric cancer. Moreover, emergency endoscopy may be useful in determining the exact source of hemorrhage and in identifying potential candidates for emergency surgery.
A complication of the infusaid pump: Duodenal atony reversed by urecholine
Authors: Silberman Allan W. , Rosenkranz Eliot , Kosakowski Christopher , Chervu Arun , Sugasawara Roy I. , Ramming Kenneth P. 
Published: February 2007

AbstractThe totally implantable infusion pump (Infusaid pump) for treating metastatic disease to the liver is a new treatment that is gaining widespread acceptance. However, as might be expected for any new major surgical procedure, there are increasing reports of complications. We report a complication in which duodenal atony was caused by the infusion of the chemotherapeutic agent (FUDR) into the stomach and duodenum. The atony was totally reversed by the subcutaneous administration of Urecholine.
Surgical approach to generalized lymphadenopathy in homosexual men
Authors: Benotti Peter N. , Jenkins Roger L. , Cady Blake , O'hara Carl , Groopman Jerome E. 
Published: February 2007

AbstractSixty patients considered at risk for acquired immune deficiency syndrome (AIDS) were referred for evaluation of generalized lymphadenopathy. All patients were seropositive for antibody to human T‐lymphotropic virus type III (HTLV‐III). Multiple lymph node biopsies from different nodal areas were performed. The results were evaluated in order to see if the diagnostic yield is increased by the performance of multiple lymph node biopsies. In no case was additional diagnostic information provided by performing multiple biopsies. In patients with diffuse lymphadenopathy who are at risk for AIDS, single node excisional biopsy is indicated to rule out opportunistic infection or/and tumor.
Early and advanced gastric cancer during follow‐up of apparently benign gastric ulcer: Significance of the presence of epithelial dysplasia
Authors: Farinati F. , Cardin F. , Mario F. Di , Vianello F. , Battaglia G. , Arslan‐Pagnini C. , Cannizzaro R. , Sava G. A. , Rugge M. , Naccarato R. 
Published: February 2007

AbstractOne hundred and forty‐four patients with apparently benign gastric ulcer were endoscopically followed up in order to evaluate the outcome of the lesion. Particular attention was given to: (a) detect possible delay in diagnosing gastric cancer; (b) ascertain the frequency of association with epithelial dysplasia; (c) establish the role of markers, such as serum pepsinogen group I (PGI), and gastric juice CEA in predicting gastric ulcer evolution. Endoscopic and bioptic check‐ups were carried out during the first year at 3, 6 and 12 months after endoscopic healing of the ulcer, and then at every symptomatic recurrence. Ten patients (6.9%) were found to present histological evidence of malignancy (within 3 months in six cases, between 6 and 12 months in three cases, and after 41 months in the rest). Four cases were early gastric cancers, and six had shown dysplastic changes of the mucosa at the edge or scar of the ulcer. Serum PGI levels were not significantly different in gastric cancer patients, while gastric juice CEA levels were sharply increased compared to those of gastric ulcer patients: nine out of ten patients had values above normal range. These data suggest that: (a) there may be some delay in diagnosing gastric carcinoma, and gastric ulcer patients should be controlled routinely more than once; (b) the presence of dysplasia indicates the need for prolonged follow‐up, because of the high risk of association with or evolution into gastric cancer, and because of the higher number of early gastric cancer detections that this protocol allows; (c) further support in monitoring patients “at risk” may be afforded by gastric juice CEA determination.
Unusual extramedullary relapse of acute lymphoblastic leukemia in a bone marrow transplant patient
Authors: Cormier Mary G. , Armin Ali‐Reza , Daneshgari Firouz , Castelli Melanie 
Published: February 2007

AbstractAn unusual form of relapse of acute lymphoblastic leukemia is described in a woman who developed a solitary large focal mass of lymphoblasts in her liver and an isolated polypoid lymphoblastic mass in her uterus after bone marrow transplantation, despite continued marrow remission. Extramedullary visceral leukemic relapse in the form of such discreet focal masses is highly unusual and to our knowledge has not been described in this setting. Awareness and recognition of atypical forms of relapse are important since such a diagnosis carries critical therapeutic and prognostic implications.
Regression analyses of prognostic factors in colorectal cancer
Authors: Hannisdal Einar , Thorsen Glen 
Published: February 2007

AbstractIn a follow‐up study of 110 patients with colorectal cancer, age, sex, erythrocyte sedimentation rate (ESR), hemoglobin (Hb), leukocyte count, emergency operation, tumor site, Dukes' stage, and histologic grade were tested in survival analyses. Dukes' stage was a highly superior prognostic discriminator. In multivariate survival analysis (Cox model) elevated ESR and leukocytosis were significant prognostic factors in addition to the Dukes' stage, indicating high‐risk patients with shorter survival.
Testing chemotherapeutic combinations in the human tumor colony—forming assay
Authors: Sondak V. K. , Korn E. L. , Morton D. L. , Kern D. H. 
Published: February 2007

AbstractA total of 362 tumor specimens were tested in the Human Tumor Colony—Forming Assay for sensitivity to one of eight drug combinations and to each component drug as a single agent. Peak pharmacologically achievable concentrations of drug were used in continuous exposure. In 175 assays greater than 50% inhibition of colony formation, defined as in vitro sensitivity, was observed for at least one drug. The percent inhibition of the most active single agent closely approximated the percent inhibition of the combination. This relationship was maintained for all tumor types and combinations tested. Resistance in vitro to each drug in a combination predicted resistance to the combination. However, our data suggest that the higher activity of combination chemotherapy relative to single agents is due to an increased probability of finding an agent to which the tumor is sensitive, rather than to a synergistic interaction between drugs.
Resection of fixed pelvic tumors using the ND:YAG laser
Authors: Brand Ely , Wade Maclyn E. , Lagasse Leo D. 
Published: February 2007

AbstractClinical experience using the Nd: YAG laser to resect intra‐abdominal malignancies is limited. Presented are two cases of recurrent gynecologic cancers, one ovarian carcinoma of low malignant potential and one fallopian tube carcinoma grade I, in which the Nd: YAG laser allowed removal of recurrent tumor fixed to sacral bone and pelvic sidewall. The ability to accomplish laser vaporization of the tumor bed along with periosteum may reduce the risk of local recurrence. Further investigation of laser treatment of tumors fixed to sacral or pubic bone, pelvic sidewall tissues or other structures should lead to the evolution of the Nd: YAG laser as a useful tool to the cancer surgeon.
Hepatocellular and gastric carcinoma associated with familial polyposis coli
Authors: Laferla G. , Kaye S. B. , Crean G. P. 
Published: February 2007

AbstractA case of familial polyposis coli in association with hepatocellular and gastric carcinoma is reported. No similar case has ever been documented in the world literature. This may be surprising as it is well known that familial polyposis has a potent oncogenicity not only in the colon but also in extracolonic organs.
Effects of dosage and infusion time on the incorporation of 5‐fluorouracil into DNA and RNA of normal tissues and an adenocarcinoma transplanted to rat liver
Authors: Erichsen Christian , Christensson Per‐Inge , Jacobsson Birgitta , Jönsson Pre‐Ebbe , Stenram Unne 
Published: February 2007

AbstractIn a model of secondary liver cancer in Wistar rats the incorporation of 5‐FUra into the acid soluble fraction, RNA, and DNA of several normal tissues and of an adenocarcinoma of the colon transplanted to the liver was determined; 300, 1,200 or 24,000 nmoles of 5‐FUra were infused via the gastroduodenal artery for 0.5, 2, or 24 hr. The rats were killed 1.5, 3, or 24 hr after the beginning of the infusions. In general, higher doses resulted in a higher labelling. However, the ratio of incorporation into tumor RNA compared to normal tissue RNA was higher at the 1,200 than at the 24,000 nmole dosage. There was a decreased RNA/DNA ratio in the tumor at 24 hr after 24,000 nmoles of 5‐FUra had been infused over 0.5 or 2 hr, indicating decreased synthesis and/or increased breakdown of RNA.
Neuroma of the common bile duct
Authors: Rush Benjamin F. , Stefaniwsky Andrew B. , Sasso Albert , Dumitrescu Ilie , Wexler David 
Published: February 2007

AbstractTwo cases of neuroma of the common bile duct (CBD) associated with jaundice and cholangitis both 15 years after cholecystectomy are presented. The surgical treatment, excision of the diseased CBD, followed by Roux‐en‐Y biliary drainage in one case and excision of the tumor with T‐tube drainage in the other, was curative. A review of the world literature revealed 20 prior cases of CBD neuromas, 19 associated with jaundice. None was diagnosed prior to operation or autopsy. Mortality of treatment was 15% and all deaths were associated with a failure to excise the neuroma.
Effect of chronically‐administered secretin on the nude mouse
Authors: Johnson Frank E. , Laregina Marie C. , Devine Joseph E. , Hudd Charles 
Published: February 2007

AbstractSecretin plays an important role in the growth regulation of certain cancers in vitro. The nude mouse is a suitable model for evaluation of the effects of this hormone on tumor xenografts in vivo, but little is known about long‐term actions of secretin in this species. We investigated the impact of chronically administered synthetic porcine secretin in the nude mouse. Six groups of mice (eight animals each) received twice‐daily intraperitoneal injections of saline or secretin at 0.5, 5, 50, 500, or 5,000 g/kg for 14 days. Body weight and general health were unaffected by exogenous secretin, and no apparent behavioral effects were observed. Seven abdominal organs were examined at necropsy and all were histologically normal. The only organ that showed a weight change was the pancreas (13% decrease at the highest secretin dose). This was accompanied by decreases in DNA and RNA content, indicating pancreatic hypoplasia. Secretin administration caused changes in DNA and/or RNA content (but not protein content or weight) in liver, small bowel, cecum, and large bowel. No effect of secretin on stomach or kidney was observed. Our work demonstrates the safety of frequent injections of pharmacologie doses of secretin in this frail animal and suggests that the nude mouse is an appropriate model for the in vivo study of tumor growth regulation by secretin.
Adult Wilms' Tumor
Authors: Chang Sun‐Yran , Ma Cheng‐Ping , Lee Wei‐Hwa 
Published: February 2007

AbstractTwo well‐documented cases of Wilms' tumor in adult patients are reported. Surgery remains the treatment of choice in stage I cases with favorable cell differentiation. Adjuvant therapy with chemotherapy or radiation may be necessary in patients beyond stage I or when the cell differentiation is more anaplastic. Actinomycin D is essential and should be included in the chemotherapeutic regimen whenever it is possible.
Killing lung cancer cells at cell‐cycle phase by a new indium‐111‐bleomycin complex
Authors: Hou De‐Yan , Ordonez Jose V. , Cross Richard J. , Ross Douglas D. , Maruyama Yosh 
Published: February 2007

AbstractThe efficacy of killing small cell lung cancer (SCLC) cells at the G1, S, and G2‐M phase of the cell‐cycle by a new 111In‐bleomycin complex (111In‐BLMC) was investigated. SCLC cells (N417, H526, H209) were synchronized by double thymidine block and assessed by DNA content with flow cytometry, and the period for the maximal accumulation of cells in S, G1, or G2‐M phase was determined. Cells in different cell cycle phases were exposed to 0.9% NaCl, BLM, or 111In‐BLMC for 1 hour and observed for colony formation. The survival of H526 cells treated with 111In‐BLMC was 71% (for enriched S phase), 46% (G1), and 31% (G2‐M). For N417 cells, it was 25% (S), 20% (G1), and 8% (G2‐M) for 111In‐BLMC and 18%% (S), 33% (G1), and 10% (G2‐M) for BLM. These results indicated that SCLC cells in G2‐M were most sensitive and those in S phase were least sensitive to 111In‐BLMC; cells in G1 phase were the least sensitive to BLM.