bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oleamide derivatives suppress the spontaneous metastasis by inhibiting connexin 26
Authors: Ohba Yusuke , Kanao Yukiko , Morita Nobuyoshi , Fujii Eri , Hohrai Mai , Takatsuji Mayuko , Hirose Hideki , Miura Daisaku , Watari Akihiro , Yutsudo Masuo , Zhao Hanjun , Yabuta Norikazu , Ito Akihiko , Kita Yasuyuki , Nojima Hiroshi 
Published: February 2007

AbstractWe previously reported that overexpressing connexin 26 (Cx26) enhances the spontaneous metastasis of mouse BL6 melanoma cells. In contrast, daily intraperitoneal injections of an oleamide derivative named MI‐18 potently inhibits the spontaneous metastasis of BL6 cells. In the present study, we chemically synthesized a novel oleamide derivative named MI‐22 and found that it also efficiently suppressed the spontaneous metastasis of BL6 cells. Both MI‐18 and MI‐22 inhibited the gap junction‐mediated intercellular communications (GJIC) that are formed between HeLa cells by the ectopic expression of the hCx26 and hCx32 human connexin subtypes; however, they had no effect on GJIC mediated by hCx40, hCx43 or hCx45. Fluorescently labeled MI‐18 primarily localized not only at plasma membrane but also at Golgi/endosome. This suggests that this oleamide derivative may also act on the Cx26 molecules that accumulate in the Golgi/endosome because of their overexpression. Notably, neither derivative had a cytotoxic effect on HeLa cells when they were added into the tissue culture medium. Taken together, we propose that the MI‐18 and MI‐22 oleamide derivatives may serve as prototypes for novel and clinically important anticancer drugs. © 2007 Wiley‐Liss, Inc.
Psychosocial predictors and correlates of dysphoria in adolescent and young adult Latinas
Authors: Locke Thomas F. , Newcomb Michael D. , Duclos Alisa , Goodyear Rodney K. 
Published: February 2007

AbstractThis study determined how multiple ecodevelopmental domains influenced dysphoria in a community sample of Latina adolescents. Risk factors tested include childhood maltreatment, parental alcohol‐related problems, and polysubstance problems. Protective factors include general self‐efficacy, social conformity, and family connection. Female participants ( N = 904) were recruited from the Los Angeles area. Many significant correlations were found between the ecodevelopmental domains and dysphoria. The strongest unique protective factor was family connection; others were social conformity and general self‐efficacy. The only unique risk factor that emerged was physical neglect. © 2007 Wiley Periodicals, Inc.
Current fear of crime, sense of community, and loneliness in italian adolescents: The role of autonomous mobility and play during childhood
Authors: Prezza Miretta , Pacilli Maria Giuseppina 
Published: February 2007

AbstractA structural equation model was used to examine the role of autonomous mobility and play in public and semipublic places in childhood to predict adolescents' sense of community, fear of crime, and, through the mediation of these two last psychosocial factors, feelings of loneliness. Participants included 789 Italian students (469 females and 320 males; mean age 16.62, SD = 0.69). The instruments used were the Italian Sense of Community Scale, the Neighborhood Relations Scale, and the UCLA Loneliness Scale. A questionnaire was also administered to investigate the adolescents' current fear of crime and their autonomous mobility when they were children by asking them to recall their play habits and independent mobility at 8–10 years of age. The structural equation model proved satisfying: Higher autonomous mobility and higher use of public places for play in childhood predicted less intense fear of crime and a stronger sense of community in adolescence. Furthermore, a better relationship with community predicted less pervasive feelings of loneliness. The simultaneous multigroup analysis showed that the final model was comparable for both girls and boys with only one difference. © 2007 Wiley Periodicals, Inc.
Support for military families and communities
Authors: Hoshmand Lisa Tsoi , Hoshmand Andrea L. 
Published: February 2007

AbstractThis is a call for community psychologists to engage in research, consultation, and program development and evaluation in supporting military families and communities. Barriers to such involvement are identified and discussed. It is argued that the needs of military families and communities cannot be ignored when military and civilian communities alike are affected by changes in the geopolitical situation and the effects of increased deployment. Examples of previous work related to military families and communities that have implications for policy and practice are presented in relation to concepts and practices in community psychology. Specific research and community approaches are suggested for future needs assessment and program development in enhancing community capacity and family resilience. © 2007 Wiley Periodicals, Inc.
Television and attitudes toward mental health issues: Cultivation analysis and the third‐person effect
Authors: Diefenbach Donald L. , West Mark D. 
Published: February 2007

AbstractA television content analysis and survey of 419 community respondents supports the hypothesis that media stereotypes affect public attitudes toward mental health issues. A content analysis of network, prime‐time television demonstrates that portrayals are violent, false, and negative. The mentally disordered are portrayed as 10 times more likely to be a violent criminal than nonmentally disordered television characters. A survey demonstrates that as television viewing increases so does the belief among viewers that locating mental health services in residential neighborhoods will endanger the residents. Viewers who watch television news are less likely to support living next to someone who is mentally ill. The survey also tests the third‐person effect, and finds that viewers believe television portrayals of mental illness affect others more than themselves. © 2007 Wiley Periodicals, Inc.
“You have to adapt because you have no other choice”: The stories of strength and resilience of 208 homeless youth in New York City and Toronto
Authors: Kidd Sean A. , Davidson Larry 
Published: February 2007

AbstractPresented in this paper are the results of a qualitative analysis of the narratives of 208 homeless youth interviewed on streets and in agencies in New York City and Toronto. The interviews focused on the participants' stories about their struggles to survive and negotiate meaningful and healthy lives in coming to the streets, living on the streets, and finding ways off the streets. Analysis of the narratives revealed shifts in the youths' senses of self/identity, and related understandings of agency, self‐worth, value systems, and connectedness in their various efforts to adapt to a range of street and nonstreet contexts. © 2007 Wiley Periodicals, Inc.
Assessing residential segregation among medicaid recipients with psychiatric disability in Philadelphia
Authors: Metraux Stephen , Caplan Joel M. , Klugman Dutch , Hadley Trevor R. 
Published: February 2007

AbstractThis study assesses the extent of residential segregation among 15,246 people diagnosed with psychiatric disabilities and receiving Medicaid (MA) in Philadelphia, and an identically sized group of MA recipients serving as matched controls. Results indicate that overall levels of residential segregation among this group were modest at their most extreme, were not markedly different from a control group of Medicaid recipients without any record of treatment for severe mental illness, and were substantially reduced after taking poverty into account. There were, however, localized areas in Philadelphia that showed distinct concentrations of persons with psychiatric disability, suggesting there may be a subgroup that is more at‐risk for living in areas with elevated concentrations of persons with serious psychiatric disability. © 2007 Wiley Periodicals, Inc.
Can magnetic resonance imaging–derived bone models be used for accurate motion measurement with single‐plane three‐dimensional shape registration?
Authors: Moro‐oka Taka‐aki , Hamai Satoshi , Miura Hiromasa , Shimoto Takeshi , Higaki Hidehiko , Fregly Benjamin J. , Iwamoto Yukihide , Banks Scott A. 
Published: February 2007

AbstractThe purpose of this study was to compare three‐dimensional (3D) kinematic measurements from single‐plane radiographic projections using bone models created from magnetic resonance imaging (MRI) and computed tomography (CT). MRI is attractive because there is no ionizing radiation, but geometric field distortion and poor bone contrast degrade model fidelity compared to CT. We created knee bone models of three healthy volunteers from both MRI and CT and performed three quantitative comparisons. First, differences between MRI– and CT–derived bone model surfaces were measured. Second, shape matching motion measurements were done with bone models for X‐ray image sequences of a squat activity. Third, synthetic X‐ray images in known poses were created and shape matching was again performed. Differences in kinematic results were quantified in terms of root mean square (RMS) error. Mean differences between CT and MRI model surfaces for the femur and tibia were −0.08 mm and −0.14 mm, respectively. There were significant differences in three of six kinematic parameters comparing matching results from MRI–derived bone models and CT–derived bone models. RMS errors for tibiofemoral poses averaged 0.74 mm for sagittal translations, 2.0 mm for mediolateral translations, and 1.4° for all rotations with MRI models. Average RMS errors were 0.53 mm for sagittal translations, 1.6 mm for mediolateral translations, and 0.54° for all rotations with the CT models. Single‐plane X‐ray imaging with model‐based shape matching provides kinematic measurements with sufficient accuracy to assess knee motions using either MRI– or CT–derived bone models. However, extra care should be taken when using MRI–derived bone models because model inaccuracies will affect the quality of the shape matching results. © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:867–872, 2007
The influence of land management on soil erosion in the Sneeuberg Mountains, Central Karoo, South Africa
Authors: Keay‐Bright J. , Boardman J. 
Published: February 2007

AbstractFarm practices in the Sneeuberg Mountains, Karoo, South Africa are examined to assess their contribution to the development of the observed gullies and badlands. Data from the literature is augmented by interviews with local farmers and measurements in the field. Changes in stocking rates, grazing systems and technological advances are assessed for their impact on soil erosion, vegetation cover and species composition. The possibility of natural and managed rehabilitation of badland areas is discussed, as are future prospects for farm management in the Sneeuberg. The findings suggest that high stock numbers and less benign management practices in the 19th century and the early 20th century underlie much of the degradation seen today. Copyright © 2007 John Wiley & Sons, Ltd.
The Relationship between task complexity and information search: The role of self‐efficacy
Authors: Hu Jing , Huhmann Bruce A. , Hyman Michael R. 
Published: February 2007

AbstractPrior research suggests the complexity of a product choice task is inversely related to the extent of consumers' external information search. The resource‐matching perspective holds that cognitive effort (e.g., external information search) is greatest when available cognitive resources (e.g., as determined by self‐efficacy) match the cognitive demands of a task (e.g., perceived task complexity). Within a brand‐choice context, the relationship between self‐efficacy and extent of information search appears nonmonotonic. In support of the resource‐matching perspective, consumers conduct the most extensive information search when their self‐efficacy matches perceived task difficulty. © 2007 Wiley Periodicals, Inc.
Allopeptide‐pulsed dendritic cells and composite tissue allograft survival
Authors: Nguyen Vu T. , Taieb Aurele , Sacks Justin M. , Unadkat Jignesh V. , Clavijo Julio A. , Kim Haena , Feili‐Hariri Maryam , Lee W. P. Andrew 
Published: February 2007

AbstractComposite tissue allografts (CTAs) contain their own reservoir of vascularized bone marrow, offering novel aspects for the induction of donor‐specific tolerance. Additionally, the manipulation of recipient dendritic cells, pulsed with donor allopeptide, has been shown to engender solid organ allograft survival. To exploit these modalities, we have developed a protocol utilizing injection of recipient bone marrow‐derived dendritic cells (BMDCs) pulsed with a donor‐derived peptide for use in CTA transplantation. Six days prior to orthotopic hind‐limb transplantation, Lewis rats received IV injection of donor allopeptide‐pulsed, recipient BMDCs, in conjunction with a single dose of anti‐lymphocyte serum. Control groups displayed signs of allograft rejection within 5 days postoperatively. Animals within the primary experimental cohort demonstrated prolongation of graft survival to an average of 8 days, and exhibited low numbers of donor T cells. The use of BMDCs in conjunction with transient immunosuppression has potential therapeutic application for induction of donor‐antigen‐specific tolerance to hind limb allografts. © 2007 Wiley‐Liss, Inc. Microsurgery, 2007.
PLGA 90/10 and caprolactone biodegradable nerve guides for the reconstruction of the rat sciatic nerve
Authors: Luis Ana L. , Rodrigues Jorge M. , Amado Sandra , Veloso António P. , Armada‐Da‐silva Paulo A. S. , Raimondo Stefania , Fregnan Federica , Ferreira António J. , Lopes Maria A. , Santos José D. , Geuna Stefano , Varejão Artur S. P. , Maurício Ana C. 
Published: February 2007

AbstractThe purpose of this study was to test in vivo two different nerve guides for promoting nerve regeneration across a 10‐mm gap of the rat sciatic nerve: 1) one made of PLGA in a novel proportion (90:10) of the two polymers poly(L‐lactide):poly(glycolide); 2) another made of (DL‐lactide‐ϵ‐caprolactone) copolyester (Neurolac®) tube, by comparing its healing efficacy with that of the more traditional methods of end‐to‐end nerve suture and autologous graft. Motor and sensory functional recovery were assessed throughout the healing period of 20 weeks, and the repaired nerves were processed for morphological and histomorphometrical analysis. Both motor and sensory functions improved significantly in all experimental nerve repaired groups. At the end of the 20‐week follow‐up, the end‐to‐end group showed better recovery of motor function when compared with the groups treated with guiding tubes. However, at this time point, the level of motor function in the Neurolac® and PLGA groups was similar to the one of the graft group. Nociception function also recovered faster in the end‐to‐end group compared with the Neurolac® and PLGA groups, and in this case, recovery was also delayed in the graft group. At the end of follow‐up, nociception was similar in all experimental groups. Morphological and histomorphometrical analysis showed that axon regeneration occurred in both PLGA and Neurolac® experimental groups, with no significant differences in the total number of regenerated fibers, but disclosed a different pattern of degradation of the two types of tubes with larger biodegradation of PLGA material by the end of 20 weeks. These results suggest that both types of biomaterials are a good substrate for preparing tubular nerve guides, and their different pattern of degradation does not seem to influence the degree of nerve regeneration. © 2007 Wiley‐Liss, Inc. Microsurgery, 2007.
Use of motor nerve material in peripheral nerve repair with conduits
Authors: Lloyd Brendan M. , Luginbuhl Ryan D. , Brenner Michael J. , Rocque Brandon G. , Tung Thomas H. , Myckatyn Terence M. , Hunter Daniel A , Mackinnon Susan E. , Borschel Gregory H. 
Published: February 2007

AbstractWe have recently shown in experimental nerve injury models that nerve regeneration is enhanced across a motor nerve graft as compared with a sensory nerve graft. To test the hypothesis that nerve architecture may mediate the beneficial effect of motor nerve grafting, we developed a model of disrupted nerve architecture in which motor and sensory nerve fragments were introduced into silicone conduits. Lewis rats were randomized to 5 experimental groups: nerve repair with motor nerve fragments, sensory nerve fragments, mixed nerve fragments, saline‐filled conduit (negative control), or nerve isograft (positive control). At 6, 9, or 12 weeks, animals were sacrificed and nerve tissues were analyzed by quantitative histomorphometry. No significant differences were observed between the motor, sensory, and mixed nerve fragment groups. These findings suggest that intact nerve architecture, regardless of neurotrophic or biochemical factors, is a prerequisite for the beneficial effect of motor nerve grafting. © 2007 Wiley‐Liss, Inc. Microsurgery, 2007.
Asymmetric invariants for a class of strictly hyperbolic systems including the Timoshenko beam
Authors: Marchionna Clelia , Panizzi Stefano 
Published: February 2007

AbstractWe introduce a set of conserved quantities of energy‐type for a strictly hyperbolic system of two coupled wave equations in one space dimension. The system is subject to mechanical boundary conditions. Some of these invariants are asymmetric in the sense that their defining quadratic form contains second order derivatives in only one of the unknowns. We study their independence with respect to the usual energies and characterize their sign. In many cases, our results provide sharp well‐posedness and stability results. Finally, we apply some of our conservation laws to the study of a singular perturbation problem previously considered by J. Lagnese and J. L. Lions. Copyright © 2007 John Wiley & Sons, Ltd.
1H NMR spectroscopic study of complexation of citalopram with β‐cyclodextrin in aqueous solution
Authors: Mashhood Ali Syed , Maheshwari Arti , Inder Fozdar Bharat 
Published: February 2007

Abstract1H NMR spectroscopic study of citalopram (CT) in the absence as well as in the presence of β‐cyclodextrin (β‐CD) in aqueous solution revealed the formation of four 1:1 β‐CD–CT inclusion complexes. The stoichiometry of the complexes was determined by the continuous variation (Job) method, which was further confirmed by Scott's method. The binding constants (KR and KR, S) were calculated using Scott's method. The structures of all the complexes have been proposed as shown in the diagrams. All the CT proton resonances showed splitting in the presence of β‐CD, owing to chiral discrimination by the β‐CD, between the two enantiomers. The chiral discrimination appears to be due to different modes of binding of the R‐ and S‐CT in the complexes involving a CN‐containing aromatic ring. Copyright © 2007 John Wiley & Sons, Ltd.
Efficient production of intersubspecific hybrid mice and embryonic stem cells by intracytoplasmic sperm injection
Authors: Shinmen Akie , Honda Arata , Ohkawa Mika , Hirose Michiko , Ogonuki Narumi , Yuzuriha Misako , Miki Hiromi , Mochida Keiji , Inoue Kimiko , Abe Kuniya , Ito Masao , Ogura Atsuo 
Published: February 2007

AbstractRecently, mice and embryonic stem (ES) cells with allelic polymorphisms have been used extensively in the field of genetics and developmental biology. In this study, we examined whether intersubspecific hybrid mice and ES cells with these genotypes can be efficiently produced by intracytoplasmic sperm injection (ICSI). Frozen‐thawed spermatozoa from wild‐derived strains, JF1 (Mus musculus molossinus), MSM (M. m. molossinus), HMI (M. m. castaneus), and SWN (M. m. spp.), were directly injected into mature oocytes from laboratory mice ([C57BL/6 × DBA2]F1; M. m. domesticus). The in vitro and in vivo developmental capacity of F1 embryos was not significantly different among the groups (P > 0.05), and term offspring were efficiently obtained in all groups (27%–34% of transferred embryos). However, the mean body and placental weights of the offspring differed significantly with genotype (P < 5 × 10−10), with the HMI hybrid greatest in both body and placental weights. In an application study using these F1 offspring, we analyzed their mitochondrial DNA using intersubspecific polymorphisms and found the consistent disappearance of sperm mitochondrial DNA in the F1 progeny. In a second series of experiments, we generated F1 blastocysts by injecting MSM spermatozoa into C57BL/6 oocytes and used them to generate hybrid ES cell lines. The ES cell lines were established at a high efficiency (9 lines from 20 blastocysts) and their allelic polymorphisms were confirmed. Thus, ICSI using cryopreserved spermatozoa allows the efficient and immediate production of a number of F1 hybrid mice and ES cell lines, which can be used for polymorphic analysis of mouse genetics. Mol. Reprod. Dev. 74: 1081–1088, 2007. © 2007 Wiley‐Liss, Inc.
Vascular endothelial growth factor stimulates the primary to secondary follicle transition in bovine follicles in vitro
Authors: Yang M.Y. , Fortune J.E. 
Published: February 2007

AbstractLittle is known about the mechanisms regulating the growth of early preantral follicles, especially in nonrodent mammalian species. To test the hypothesis that vascular endothelial growth factor (VEGF) promotes the primary to secondary follicle transition, pieces of bovine fetal ovarian cortex were cultured with VEGF (0, 1, 10, or 100 ng/ml) for 0 or 10 days, followed by morphometric analysis. On day 0, cortical pieces contained mostly primordial follicles, but after 10 days in vitro most primordial follicles had activated, differentiating into primary follicles. VEGF had no effect on the numbers of primordial or primary follicles, compared with untreated controls, but all doses increased the number of secondary follicles. In the second experiment, a range of lower doses of VEGF (0.1–10 ng/ml) increased the number of secondary follicles in a dose‐dependent manner. Analysis of VEGF transcripts by RT‐PCR showed expression of mRNA for three isoforms of VEGF (VEGF121, 165, and 189) in fetal bovine ovarian cortex, with VEGF121 and 165 expressed predominantly and levels of mRNA for VEGF121 and 189 increasing after day 211 of gestation, when the first secondary follicles appear. Expression of mRNA for both VEGF receptors (flt‐1 and flk‐1) was also detected, but did not change with the development of fetal ovaries. Immunohistochemistry revealed positive staining for VEGF in blood vessels and in follicle cells of secondary follicles, consistent with Western blot analyses showing increases in VEGF protein as ovarian development progressed. Taken together, the results provide support for a role for VEGF in the primary to secondary follicle transition. Mol. Reprod. Dev. 74: 1095–1104, 2007. © 2007 Wiley‐Liss, Inc.