bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECT OF SCAPULAR TAPING ON PAIN, DISABILITY AND PROPRIOCEPTION IN SUBJECTS WITH SHOULDER IMPINGEMENT SYNDROME: A RANDOMIZED CONTROLLED TRIAL
Authors: Gautam Mridu , Venkatesan Prem , Prakash Nithin , Kalyan Hemant K. , Harikesavan Karvannan 
Published: April 2024

Context: Shoulder Impingement Syndrome (SIS) is a common clinical condition in general practice and overhead athletes. Alterations in the scapular position can lead to shoulder impingement syndrome. The effect of exercises on shoulder impingement syndrome is studied but the effect of Kinesiotape is not well explored. Methods: A total of 42 participants were included in the study. The subjects were assessed for SPADI, pain, proprioception, lateral scapula slide test, and pectoral minor length test at the baseline and the subjects were randomly divided into two groups. The intervention group ([Formula: see text] = 18) received scapular taping and scapular exercises and the control group ([Formula: see text] = 17) received scapular exercises only. Post-outcome measures were taken at 4 weeks and 12 weeks during the intervention. Repeated measures ANOVA was used for the outcome measures and Bonferroni’s test was used to determine the pairwise comparisons at different measurement levels amongst experimental and control groups. Results: The study consisted of 17 males and 18 females. There was statistical significance in both groups ([Formula: see text] < 0.01) over the 4th and 12th weeks. Pain ([Formula: see text] < 0.01) and proprioception ([Formula: see text] = 0.017) was also statistically significant between both the groups at 4 weeks. Conclusion: This study concludes that scapular taping can be used as an adjunct with scapular involvement.
Reintroducing Time, Money and Constraints: Viability to Bridge the Economic and Monetary Theories
Authors: Aubin Jean-Pierre , Aubin-Frankowski Pierre-Cyril , Lozève Vladimir 
Published: April 2024

Why use a viabilistic approach to model economy? Because it is urgent to re-assess the modeling of the business cycle that integrates dynamic money creation and that has at its core the notion of constraints. The purpose of this paper is thus to propose an evolutionary economic model using a mathematical framework derived from set-valued analysis, differential inclusions and viability theory. As this approach is dynamical, the model will not use two concepts on which neo-classical economics are built i.e., (1) the existence of static repeated equilibria, (2) the optimization by an economic agent of a utility function. Furthermore, we will not use any self-organization process or “invisible hand”, as in our viabilist framework the economic viability will be maintained by explicit choices of the economic agents and of the lender of last resort over the budgetary and monetary rules to apply. Indeed, even simple constraints on the second-derivative of the means of payments already induce four-phased business cycles. Coupling these constraints over the creation of means of payment with economic evolutions of prices and commodities through a budgetary constraint allows for a single formalism, tackling jointly the question of the viability of economic and monetary evolutions.
On the uniqueness of variable coefficient Schrödinger equations
Authors: Federico Serena , Li Zongyuan , Yu Xueying 
Published: April 2024

In this paper, we prove unique continuation properties for linear variable coefficient Schrödinger equations with bounded real potentials. Under certain smallness conditions on the leading coefficients, we prove that solutions decaying faster than any cubic exponential rate at two different times must be identically zero. Assuming a transversally anisotropic type condition, we recover the sharp Gaussian (quadratic exponential) rate in the series of works by Escauriaza–Kenig–Ponce–Vega [On uniqueness properties of solutions of Schrödinger equations, Comm. Partial Differential Equations 31(10–12) (2006) 1811–1823; Hardy’s uncertainty principle, convexity and Schrödinger evolutions, J. Eur. Math. Soc. (JEMS) 10(4) (2008) 883–907; The sharp Hardy uncertainty principle for Schrödinger evolutions, Duke Math. J. 155(1) (2010) 163–187].
Supplementary Figure 5 from CB307: A Dual Targeting Costimulatory Humabody V<sub>H</sub> Therapeutic for Treating PSMA-Positive Tumors
Authors: Archer Sophie , Brailey Phillip M. , Song Minjung , Bartlett Phillip D. , Figueiredo Ines , Gurel Bora , Guo Christina , Brucklacher-Waldert Verena , Thompson H. Lorraine , Akinwale Jude , Boyle Samantha E. , Rossant Christine , Birkett Neil R. , Pizzey Julia , Maginn Mark , Legg James , Williams Richard , Johnston Colette M. , Bland-Ward Philip , de Bono Johann S. , Pierce Andrew J. 
Published: April 2024

<p>Supplementary Figure 5: CB307 binding to cell-presented targets</p>
Supplementary Figure 10 from CB307: A Dual Targeting Costimulatory Humabody V<sub>H</sub> Therapeutic for Treating PSMA-Positive Tumors
Authors: Archer Sophie , Brailey Phillip M. , Song Minjung , Bartlett Phillip D. , Figueiredo Ines , Gurel Bora , Guo Christina , Brucklacher-Waldert Verena , Thompson H. Lorraine , Akinwale Jude , Boyle Samantha E. , Rossant Christine , Birkett Neil R. , Pizzey Julia , Maginn Mark , Legg James , Williams Richard , Johnston Colette M. , Bland-Ward Philip , de Bono Johann S. , Pierce Andrew J. 
Published: April 2024

<p>Supplementary Figure 10: hPSMA expression on RP1 tumour cells is lost over time, even in tumours dosed with HSA only</p>
Abstract LT07: Signalling Inhibition by Ponatinib Disrupts Productive Alternative Lengthening of Telomeres (ALT)
Authors: Kusuma Frances , Prabhu Aishvaryaa , Tieo Galen , Ahmad Syed Moiz , Dakle Pushkar , Yong Wai Khang , Pathak Elina , Madan Vikas , Jiang Yan Yi , Tam Wai Leong , Kappei Dennis , Dröge Peter , Koeffler H. Phillip , Jeitany Maya 
Published: April 2024

Abstract
Enabling replicative immortality is one prominent feature of cancer cells. To that end, cancer cells activate means to elongate their telomeres. While 85% of cancers re-express telomerase, around 15% of all cancers rely on the ALT (Alternative Lengthening of Telomeres) mechanism. Despite its frequency, no clinically approved ALT-targeted therapy exists to date.
By performing anti-cancer compound library screen on isogenic cell lines and using extrachromosomal telomeric C-circles, as a bona fide marker of ALT activity, we identified a receptor tyrosine kinase inhibitor, ponatinib, that deregulates ALT mechanisms, induces telomeric dysfunction, reduced ALT- associated telomere synthesis, and targets, in vivo, ALT-positive cells.
By scrutinizing the mode of action of ponatinib on ALT, we identified an ABL1-JNK-JUN signalling circuit to be inhibited by ponatinib and to have a role in suppressing extrachromosomal telomeric C-circle formation. Furthermore, transcriptome and interactome analyses of JUN suggested a role of JUN in DNA damage repair pathways, independently of its capacity as a transcription factor. These results were corroborated by new synergistic drug interactions between ponatinib and either DNA synthesis or repair inhibitors such as triciribine and KU-60019, respectively. Overall, we identified a novel signalling pathway impacting ALT which can be targeted by a clinically approved kinase inhibitor.
Citation Format: Frances Kusuma, Aishvaryaa Prabhu, Galen Tieo, Syed Moiz Ahmad, Pushkar Dakle, Wai Khang Yong, Elina Pathak, Vikas Madan, Yan Yi Jiang, Wai Leong Tam, Dennis Kappei, Peter Dröge, H. Phillip Koeffler, Maya Jeitany. Signalling Inhibition by Ponatinib Disrupts Productive Alternative Lengthening of Telomeres (ALT) [abstract]. In: Proceedings of Frontiers in Cancer Science; 2023 Nov 6-8; Singapore. Philadelphia (PA): AACR; Cancer Res 2024;84(8_Suppl):Abstract nr LT07.
Abstract P05: Novel PROTAC-based EZH2 Degraders Effectively Target Lymphoid Malignancies by Depleting Enzyme-Independent Functions of EZH2
Authors: Mustafa Nurulhuda , Alnaseri Zubaida Talal , Jian Darrel Tan Egk , Truong David Quach Thanh , Lim Wan Hsin , Chng Wee Joo 
Published: April 2024

Abstract
Overexpression or mutation of the epigenetic silencer EZH2 correlates with invasive cancer growth, resistance, and poor survival outcomes. Previously, we have established a methylation-independent role for EZH2 in the transcriptional activation of oncogenes in NKTL. As EZH2 enzymatic inhibitors have proven ineffective against NKTL, we embarked on the development of novel EZH2 Proteolysis Targeting Chimera (PROTAC) compounds. EZH2 PROTACs consist of an EZH2- and E3-ligase binding domain which promotes targeted ubiquitination of the EZH2 protein thereby marking it for proteasomal degradation.
Our initial efforts focused on the iterative synthesis of EZH2 PROTAC candidates optimizing factors such as permeability, solubility and stable ternary complex formation. Through extensive screening, we identified C2911 and C1311, which successfully trigger the dose-dependent degradation of EZH2 and PRC2 components concomitant with a significant loss of survival and induction of apoptosis in both NKTL and DLBCL. These effects were rescued by pre-treatment with proteasome inhibitor Bortezomib or when E3 ligase activity was disrupted through siRNA knockdown. In NKTL, we show that EZH2 PROTAC treatment decreased JAK3 and phospho-STAT5 protein expression and identified the suppression of the JAK-STAT-MYC axis as a potential mechanism of action. EZH2 PROTAC treatment effectively reactivates transcription of canonical EZH2 target genes such as MYT1 and ANPEP and downregulates expression of oncogenes c-Myc and E2F1. Pharmacokinetic studies in vivo demonstrate that these PROTACs exhibit good plasma stability, half-life (&gt;4h) and low clearance thereby establishing potential for future clinical development. The efficacy of EZH2 PROTACs in xenograft mice are currently being evaluated.
Collectively, our data supports the discovery of novel EZH2 PROTACs and the critical role it plays in successfully targeting the oncogenic role of EZH2 in NKTL or other non-canonical EZH2-driven cancers through protein depletion where enzymatic-only inhibition was ineffective. We are further investigating the mechanisms stabilizing EZH2 protein levels to enhance PROTAC-mediated cytotoxicity.
Citation Format: Nurulhuda Mustafa, Zubaida Talal Alnaseri, Darrel Tan Egk Jian, David Quach Thanh Truong, Wan Hsin Lim, Wee Joo Chng. Novel PROTAC-based EZH2 Degraders Effectively Target Lymphoid Malignancies by Depleting Enzyme-Independent Functions of EZH2 [abstract]. In: Proceedings of Frontiers in Cancer Science; 2023 Nov 6-8; Singapore. Philadelphia (PA): AACR; Cancer Res 2024;84(8_Suppl):Abstract nr P05.
Abstract P09: AN EX-VIVO COMBINATION DRUG SENSITIVITY PLATFORM FOR PREDICTING SENSITIVITY TO FLT3 INHIBITOR-BASED COMBINATION IN ACUTE MYELOID LEUKEMIA
Authors: Sahib Noor Rashidha Bte Meera , Ying Jen Wei , Ooi Melissa , Chee Yen Lin , Jayalakshmi  , Mohamed Jameelah Bte Sheik , Rashid Masturah , Chow Edward KH 
Published: April 2024

Abstract
FMS-like tyrosine kinase-3 (FLT3) mutations are often linked with poor prognosis in Acute myeloid leukemia (AML). Despite increasing availability of targeted therapy, such as FLT3 inhibitors (FLT3i), remission is often short-term and followed by relapse and drug resistance. With varying response rates to standard treatments, the need to understand the molecular mechanisms driving drug resistance and accurately predict responses to treatment is crucial. Here, we present the ability of Quadratic phenotypic optimization platform (QPOP), in accurately identifying potential responders to possible combination therapies in AML.
AML cell lines and AML patient samples were treated with a set panel of drugs including FLT3i. QPOP drug combination scores and ranking were derived from cell viability response following treatment. 40 patients were recruited for the study, of which 20 patients were evaluated for their clinical concordance. RNA sequencing and molecular analysis was further conducted to determine the accuracy of QPOP predicted response and to determine mechanism of resistance to FLT3i.
QPOP predicted response was concordant to patient treatment outcome with 80% sensitivity and specificity. QPOP analysis on AML cell lines accurately identified responders to FLT3i including the differential response between a FLT3- ITD isogenic parental and FLT3i resistant cell line. Serial QPOP analysis in a FLT3 mutant patient sample indicated a decrease in FLT3i sensitivity concordant with an increasing FLT3 allelic burden and the development of resistance. The development of resistance to FLT3i based combinations was correlated to an increase in phosphorylated AKT expression. Activation of AKT is associated with the upregulation of Forkhead box M1 (FoxM1) in the resistant cell line. Co-treatment with an AKT inhibitor restored sensitivity to FLT3i treatment in the resistant cells. We demonstrate that QPOP analysis accurately predicts sensitivity to drug-combinations and can be used as a tool to identify sensitivity to FLT3i-based combination therapy in AML.
Citation Format: Noor Rashidha Bte Meera Sahib, Jen Wei Ying, Melissa Ooi, Yen Lin Chee, Jayalakshmi, Jameelah Bte Sheik Mohamed, Masturah Rashid, Edward KH Chow. AN EX-VIVO COMBINATION DRUG SENSITIVITY PLATFORM FOR PREDICTING SENSITIVITY TO FLT3 INHIBITOR-BASED COMBINATION IN ACUTE MYELOID LEUKEMIA [abstract]. In: Proceedings of Frontiers in Cancer Science; 2023 Nov 6-8; Singapore. Philadelphia (PA): AACR; Cancer Res 2024;84(8_Suppl):Abstract nr P09.
Abstract P10: p44, the Amino-terminal Lacking Isoform of p53, is Dispensable for Tumor Suppression but Regulates Male Fertility
Authors: Chia RH , Phang Beng Hooi , Teo Fanny Xueting , Lau Hannah , Sabapathy Kanaga 
Published: April 2024

Abstract
p53 is the most studied tumor-suppressor, by virtue of its functional inactivation in most human cancers. One aspect that has not received sufficient attention is the function of the various forms of p53, such as p47, that lacks the amino-terminal transactivation domain. Hence, the goal of this work has been to systematically characterize p47, which was found to retain the ability to selective transactivate apoptotic target gene activation (and thus the ability to induce apoptosis), but lacks the ability to induce the expression of genes involved in cell cycle arrest. Consistently, patients with tumors that have p53 mutations that lead to p47 expression have a better prognosis. We have uncovered the mechanistic basis of the selective transcriptional activity of p47, which is associated with selective co-factor binding. In addition, we have generated mice that express only p47 (without p53), and show that they are susceptible to spontaneous tumors, like human patients who have germ-line mutations that lead to only p47 expression. Thus, p47 appears to be a null allele in mice with respect to tumor formation, and is incapable of inducing selective target gene activation nor apoptosis, highlighting species-specific differences in its functionality.
Further characterization of these mice will be reported.
Citation Format: RH Chia, Beng Hooi Phang, Fanny Xueting Teo, Hannah Lau, Kanaga Sabapathy. p44, the Amino-terminal Lacking Isoform of p53, is Dispensable for Tumor Suppression but Regulates Male Fertility [abstract]. In: Proceedings of Frontiers in Cancer Science; 2023 Nov 6-8; Singapore. Philadelphia (PA): AACR; Cancer Res 2024;84(8_Suppl):Abstract nr P10.
Atrial Fibrillation Screening During Routine Automated Office, Home, and Ambulatory Blood Pressure Measurement: A Diagnostic Test Accuracy Systematic Review and Meta-Analysis
Authors: Kyriakoulis Konstantinos G. , Kollias Anastasios , Menti Ariadni , Chardouvelis Panagiotis , Stergiou George S. 
Published: April 2024

BACKGROUND:
Atrial fibrillation (AF) is often asymptomatic and undiagnosed. As AF and hypertension often coexist, opportunistic AF detection during routine automated blood pressure (BP) measurement appears to be an attractive screening method.

METHODS:
A systematic literature search was conducted to identify studies assessing the diagnostic test accuracy of office, home, or 24-hour ambulatory BP measuring devices with AF detection algorithms versus reference electrocardiography. Analyses were performed per participant (AF status based on several BP readings; most office/home devices) or per reading (AF status based on individual readings; all ambulatory devices). A meta-analysis stratified by device type (office/home/ambulatory) was conducted to calculate pooled measures of diagnostic accuracy. Sensitivity/meta-regression analyses were also performed.

RESULTS:
Among 3096 records initially retrieved, 23 diagnostic test accuracy studies were included. Data derived from 11 093 individuals (weighted age 69 years, males 56%, hypertensives 79%, diabetics 24%, and AF prevalence 17%) indicated a pooled sensitivity 0.97 (95% CI, 0.92–0.99), specificity 0.93 (95% CI, 0.90–0.95), and accuracy 0.93 (95% CI, 0.89–0.95), with generally consistent results using office, home, or ambulatory BP devices (slightly lower specificity with the latter). The positive and negative predictive values were 0.70 (95% CI, 0.60–0.80) and 0.99 (95% CI, 0.98–1.00), respectively. Sensitivity analyses indicated lower specificity in studies implementing reading versus participant analyses. Most studies presented a low risk of bias and minor applicability concerns.

CONCLUSIONS:
There is considerable and consistent evidence suggesting high diagnostic accuracy of AF detection algorithms implemented in automated BP monitors during routine BP measurements in and out of the office. AF diagnosis requires verification (electrocardiography) before treatment is administered.
New records of earthworms (Clitellata: Oligochaeta) from Georgia, USA, including eight new state records
Authors: MCGEE JOSEPH M. , CARRERA-MARTÍNEZ ROBERTO , JR. MAC A. CALLAHAM , SNYDER BRUCE A. 
Published: April 2024

We present here new county records for 13 counties within Georgia, USA from the collections of the Georgia Museum of Natural History and the authors. These include four families, eight genera, and 23 species. Of these, eight species are new state records: Amynthas carnosus (Goto & Hatai, 1899); Aporrectodea longa (Ude, 1885); Bimastos parvus (Eisen, 1874); Diplocardia deborahae Damoff & Reynolds, 2017; Diplocardia gatesi Murchie, 1965; Diplocardia michaelseni Eisen, 1899; Metaphire hilgendorfi (Michaelsen, 1892); and Murchieona minuscula (Rosa, 1906). These findings are presented alongside an updated checklist for Middle Georgia building on data compiled by Reynolds (2015) to create a practical record for the region.
Protective Effect of Prunella vulgaris L. Whole Plant or Spicas Water Extracts on Hyperthyroidism with Liver-yang Hyperactivity Syndrome
Authors: Li Shuang , Gong Zhiguo , Hu Xiangling , Li Yufan , Yan Chao , Cao Liping , Chen Yuhang 
Published: April 2024

Background Prunella vulgaris L. (Lamiaceae) is a perennial medicinal plant commonly used to treat thyroid dysfunction, infectious hepatitis, and mastitis in north-east Asia and Europe. In China, there has been a historical change in the medicinal use of P. vulgaris from the use of whole plants to the use of the spicas. Purpose This study aimed to evaluate the protective effects of whole plant P. vulgaris water extracts and spicas on hyperthyroidism with liver-yang hyperactivity syndrome and to preliminarily explain the mechanism of action of these water extracts. Materials and Methods Rats were induced with aconite decoction and levothyroxine and treated with P. vulgaris whole plant and spicas water extract for 28 days at the same time. Body weight, food intake, and rectal temperature were monitored. The serum thyroid function indicators thyroid stimulating hormone (TSH), thyroid hormone-free triiodothyronine (FT3) and free thyroxine (FT4), liver function index alanine aminotransferase (ALT) and aspartate aminotransferase (AST), oxidative damage index malondialdehyde (MDA), and superoxide dismutase (SOD) were detected. Liver and thyroid tissues were taken for sectioning and observation. The liver inflammatory factors human tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were detected by immunohistochemistry, and the expression levels of the apoptotic proteins caspase-3 and B-cell lymphoma-2 (Bcl-2) were detected. Results Both P. vulgaris whole plant and spica water extract groups exhibited markedly reduced FT3 and FT4 contents, increased the TSH content, and decreased ALT and AST activities. Furthermore, these agents improve thyroid and liver lesion tissue; reduce MDA content; increase SOD activity; reduce IL-6, TNF-α, and caspase-3 expression; and increase Bcl-2 expression. Conclusion The whole plant and spicas water extracts of P. vulgaris have obvious protective effects on hyperthyroidism and hyperactivity in liver yang, and the protective effect of the water extract of spicas is greater than that of the whole plant water extract.
Phytochemical and Anti-inflammatory Activities of Oxytropis aciphylla
Authors: Qian Hao , Liu Jiaqiong , Meng Xianqi , Wang Xiaoqin 
Published: April 2024

Background The objective of this research is to explore the phytochemical constituents and the potential anti-inflammatory properties of the herb Oxytropis aciphylla. Materials and Methods From the ethyl acetate and n-butanol fractions derived from the 70% ethanol extract of O. aciphylla, a total of 17 distinct chemical entities were extracted and subsequently identified. Utilizing network pharmacology, the study predicted the possible anti-inflammatory targets and mechanisms of action of O. aciphylla. The study assessed the anti-inflammatory impact of O. aciphylla extract on RAW 264.7 (a murine macrophage cell line) cells induced with lipopolysaccharide (LPS) by quantifying the concentrations of nitric oxide (NO), tumor necrosis factor-alpha (TNF- α), and interleukin-6 (IL-6). Results The isolated compounds included 12 flavonoids, two triterpenoids, one fatty acid, and two sterols. These specifically comprise apigenin, luteolin, kaempferol, isorhamnetin, naringenin, eriodictyol, dihydrokaempferol, butein, 7,4’-homoisoflavanone, apigenin-7- O- β-D-glucopyranoside, isorhamnetin-3- O- β-D-gentiobioside, rutin, azukisapogenol, 3- O-[ β-D-glucopyranosyl(1↓2)- β-D-glucuronopyranosyl] azukisapogenol methyl ester, tetracosanoic acid, daucosterol, and β-sitosterol. Network pharmacology analysis suggested that O. aciphylla may exert its anti-inflammatory effects through multiple components, targets, and pathways, such as kaempferol, apigenin, luteolin, AKT1, SRC, TNF, PTGS2, EGFR, MAPK, PI3K-Akt, VEGF, HIF-1, and TNF signaling pathways. The extract of O. aciphylla was found to markedly reduce the levels of NO, TNF- α, and IL-6 in RAW 264.7 cells that were stimulated with LPS, demonstrating a correlation with the dosage administered. Conclusion The investigation uncovered, for the first time, the phytochemical constituents and the mechanisms underlying the anti-inflammatory effects of O. aciphylla. These findings lay the groundwork for the scientific development and application of this botanical species as a natural remedy for inflammation.
A short history of the British Urology Researchers in Surgical Training (BURST): The power of collaborative research
Authors: Mak Quentin , Byrnes Kevin Gerard , Nathan Arjun , Kerdegari Nikki , Khadhouri Sinan , Bhatt Nikita , Kasivisvanathan Veeru 
Published: April 2024

The British Urology Researchers in Surgical Training (BURST) is a UK-based, trainee-led urology research collaborative. Since inception in 2014, BURST has led projects in several urological subspecialties with the aim of improving urological practice for patient benefit. Key innovations we have used include an emphasis on social media communications and developing innovative technology solutions to improve collaboration. In this review article, we summarise our recent studies and highlight important strategies for performing collaborative research. Level of evidence: Not applicable.