bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apatite Chemistry as a Petrogenetic Indicator for Mafic Layered Intrusions
Authors: Kieffer Marie A , Dare Sarah A S , Namur Olivier , Mansur Eduardo T 
Published: February 2024

Abstract
Mafic layered intrusions constitute a natural laboratory to investigate petrogenetic processes using trace element variations in apatite chemistry. Although these intrusions are related to large igneous provinces, there is a wide range of parameters that can affect the chemistry of the primary melt (i.e. composition of the source, pressure, temperature, oxygen fugacity), followed by possible crustal contamination. In this study, we use a comprehensive dataset of analyses of cumulus and intercumulus apatite from a variety of mafic layered intrusions to demonstrate the use of apatite as a powerful petrogenetic indicator. The dataset (determined in this study and compiled from the literature) comprises electron microprobe and LA-ICP-MS analyses, as well as in-situ LA-MC-ICP-MS analyses of Sr isotopes in apatite from well documented layered intrusions (Sept-Iles, Skaergaard, Bushveld, Panzhihua) and the Sudbury Igneous Complex. For the first time, we show that high values of (La/Nd)N, Th, U, Pb, and As in apatite correlate with high (87Sr/86Sr)initial and are related to contamination with continental crust. An elevated (Gd/Yb)N ratio might indicate melting of a mantle source deep enough to retain Yb in garnet. We also confirm that increasingly negative Eu anomaly and decreasing Sr/Y ratio in apatite are indicators of fractional crystallisation of plagioclase, and that high Sr/Y is indicative of early saturation of apatite and/or delayed crystallisation of plagioclase. The reversal to more primitive compositions caused by magma mixing is expressed by higher Sr, V, Mg and Sr/Y ratio, and lower REE + Y, As and Na concentrations in apatite following magma replenishment. Lastly, we show that apatite signature can efficiently distinguish a mafic from a felsic intrusion using its REE and Sr content coupled to its Eu anomaly. It is also possible to further identify the more primitive from the more evolved parts of a mafic layered intrusion, using the Lu, Th, V and volatile (F/Cl) content to distinguish intercumulus from cumulus apatite, respectively. Finally, identifying a mafic magmatic system using detrital apatite in till will prove useful for provenance and mineral exploration studies.
The Crucial Role of Race in Twenty-First Century US Political Realignment
Authors: Barber Michael , Pope Jeremy C 
Published: February 2024

Abstract
Traditional realignment theory has fallen out of fashion among political scientists, yet the popular press talk about political realignments with great regularity. However, in this research note we show that political science should reconsider realignment theory because over the last decade American politics has dramatically realigned—but only for white Americans. Specifically, we demonstrate that income has gone from a highly polarizing factor to one in which there is little to no polarization at all, while at the same time education polarization has increased dramatically to become the prominent demographic cleavage in the white segment of the electorate. However, no such realignment has occurred among Black or Latino voters. These differences across racial groups show how it is essential to consider race in theories of realignment, particularly because of the different experiences across racial groups. Realignment theory is quite viable in the twenty-first century, but the lens of race is the key to seeing the white realignment.
Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1
Authors: Ma Wei , Zhang Lu , Chen Weilong , Chang Zhaoxia , Tu Juchuanli , Qin Yuanyuan , Yao Yuwen , Dong Mengxue , Ding Jiajun , Li Siqin , Li Fengkai , Deng Qiaodan , Yang Yifei , Feng Tingting , Zhang Fanrong , Shao Xiying , He Xueyan , Zhang Lixing , Hu Guohong , Liu Quentin , Jiang Yi-Zhou , Zhu Shu , Xiao Zhi , Su Dan , Liu Tong , Liu Suling 
Published: February 2024

Abstract
Tumor-resident microbiota in breast cancer promotes cancer initiation and malignant progression. However, targeting microbiota to improve the effects of breast cancer therapy has not been investigated in detail. Here, we evaluated the microbiota composition of breast tumors and found that enterotoxigenic Bacteroides fragilis (ETBF) was highly enriched in the tumors of patients who did not respond to taxane-based neoadjuvant chemotherapy. ETBF, albeit at low biomass, secreted the toxic protein BFT-1 to promote breast cancer cell stemness and chemoresistance. Mechanistic studies showed that BFT-1 directly bound to NOD1 and stabilized NOD1 protein. NOD1 was highly expressed on ALDH+ breast cancer stem cells (BCSCs) and cooperated with GAK to phosphorylate NUMB and promote its lysosomal degradation, thereby activating the NOTCH1-HEY1 signaling pathway to increase BCSCs. NOD1 inhibition and ETBF clearance increase the chemosensitivity of breast cancer by impairing BCSCs.
Overcoming provider barriers to therapeutic drug monitoring of tumour necrosis factor inhibitors for rheumatoid arthritis: a qualitative analysis
Authors: Gavan Sean P , Payne Katherine , Barton Anne 
Published: February 2024

Abstract

Objective
Therapeutic drug monitoring (TDM) of tumour necrosis factor-α inhibitors (TNFi), by measuring drug levels and/or anti-drug antibodies, is being considered by various international bodies to improve patient health outcomes and the value of care for people with rheumatoid arthritis. Rheumatology care providers may perceive barriers to adopting TNFi TDM within their own clinical practice, limiting the potential for patients and health care systems to benefit. This study aimed to explore the barriers perceived by rheumatologists that may reduce their uptake of TNFi TDM for rheumatoid arthritis.

Method
Semi-structured one-to-one telephone interviews were performed with a convenience sample of senior rheumatologists with experience of managing people with rheumatoid arthritis. The interviews explored the rheumatologists’ understanding of TDM and their beliefs about how it can be integrated into their own routine practice. Interviews were audio recorded, transcribed verbatim and anonymized. Transcripts were coded inductively and barriers to using TNFi TDM were identified by thematic framework analysis.

Result
A sample of eleven senior rheumatologists were interviewed. The rheumatologists described five barriers to adopting TNFi TDM in routine practice: (i) observing clinical need; (ii) understanding how testing can improve practice; (iii) insufficient clinical evidence; (iv) insufficient resources to pay for testing; and (v) insufficient capability to deliver testing.

Conclusion
Barriers to adopting TNFi TDM in routine care settings will restrict the ability for patients to benefit from effective monitoring strategies as they begin to emerge. Strategies to overcome these barriers are suggested which will require a coordinated response from stakeholders across health care systems.
Patients’ unmet needs and treatment preferences concerning digital ulcers in systemic sclerosis
Authors: Bandini Giulia , Alunno Alessia , Alcacer-Pitarch Begonya , Ruaro Barbara , Galetti Ilaria , El-Aoufy Khadija , Pinheiro Filipe , Campanaro Giulia , Jade Judith , Di Donato Stefano , Muir Lindsay , Moggi Pignone Alberto , Bellando Randone Silvia , Del Galdo Francesco , McMahan Zsuzsanna H , Matucci-Cerinic Marco , Hughes Michael 
Published: February 2024

Abstract

Objective
Digital ulcers (DUs) significantly impact on quality of life and function in patients with systemic sclerosis (SSc). The aim of our survey was to explore patients’ perspectives and their unmet needs concerning SSc-DUs.

Methods
SSc patients were invited through international patient associations and social media to participate in an online survey.

Results
A total of 358 responses were obtained from 34 countries: US (65.6%), UK (11.5%) and Canada (4.5%). Recurrent DUs were found to be common: &gt;10 DUs (46.1%), 5–10 DUs (21.5%), 1–5 DUs (28.5%), 1 DU (3.9%). Fingertip DUs were most frequent (84.9%), followed by those overlying the IP joints (50.8%). The impact of DUs on patients is considerable, from broad-ranging emotional impacts to impact on activities of daily living, and on personal relationships. Around half of the respondents (51.7%) reported that they received wound/ulcer care, most often provided by non-specialist wound care clinics (63.8%). There was significant variation in local (wound) DU care, in particular regarding the use of debridement and pain management. DU-related education was only provided to one-third of patients. One-quarter of the patients (24.6%) were ‘very satisfied’ or ‘satisfied’ that the provided DU treatment(s) relieved their DU symptoms. Pain, limited hand function, and ulcer duration/chronicity were the main reasons for patients to consider changing DU treatment.

Conclusion
Our data show that there is a large variation in DU treatment between countries. Patient access to specialist wound-care services is limited, and only a small proportion of patients had their DU needs met. Moreover, patient education is often neglected. Evidence-based treatment pathways are urgently needed for DU management.
Follow Father or Mother? Understanding the Monoethnic Identification of Biethnic Children in China
Authors: Mu Zheng , Francis-Tan Andrew 
Published: February 2024

Abstract
In China, children’s ethnicity is often decided by their parents at the time of birth or during childhood; individuals are only allowed to be identified by a single ethnicity. Ethnic identification is therefore a contested issue shaped by the intra-family power structures that determine which parent’s ethnic heritage will be passed down. In this paper, we use China’s 2005 and 2015 inter-census surveys to examine the factors impacting the ethnic identification of children in interethnic families. We find the likelihood that children are identified with their fathers’ ethnicity decreased between 2005 and 2015. Relative to children with a minority mother and a Han father, those with a Han mother and a minority father, and those with parents from different minority groups have higher odds of following their father’s ethnicity. Being a girl, being older, having more educated parents, having urban or migrant status, and living in prefectures with a higher concentration of ethnic minorities all tend to lower the odds of identifying with the father. Moreover, stratified models demonstrate that in families where the father is the only minority parent, Islamic heritage positively predicts boys’ adoption of fathers’ ethnicity, but negatively predicts girls’ adoption. Eligibility for bonus points on the college entrance exam is negatively associated with the odds of following father when the mother is the only minority parent, but the association turns positive when the father is the only minority parent. The results illustrate the nuanced social processes involved in the social construction of ethnic identification.
The effects of genotype-by-environment interactions on body condition score across three winter supplemental feed environments in a composite beef cattle breed in Montana
Authors: Ling Ashley S , Hay El Hamidi 
Published: February 2024

Abstract
Cattle operations in the Northern Great Plains region of the United States face extreme cold weather conditions and require nutritional supplementation over the winter season in order for animals to maintain body condition. In cow–calf operations, body condition scores (BCS) measured at calving and breeding have been shown to be associated with several economically important health and fertility traits, so maintenance of BCS is both an animal welfare and economic concern. A low-to-medium heritability has been found for BCS when measured across various production stages, indicating a large environmental influence but sufficient genetic basis for selection. The present study evaluated BCS measured prior to calving (late winter) and breeding (early summer) under three winter supplementation environments in a multitrait linear mixed model. Traits were discretized by winter supplementation and genetic correlations between environments were considered a reflection of evidence for genotype-by-environment interactions between BCS and diet. Winter supplementation treatments were fed October through April and varied by range access and protein content: 1) feedlot environment with approximately 15% crude protein (CP) corn/silage diet, 2) native rangeland access with 1.8 kg of an 18% CP pellet supplement, and 3) native rangeland access with a self-fed 50% CP and mineral supplement. A total of 2,988 and 2,353 records were collected across multiple parities on 1,010 and 800 individuals for prebreeding and precalving BCS, respectively. Heifers and cows came from a composite beef cattle breed developed and maintained by the USDA Fort Keogh Livestock and Range Research Laboratory near Miles City, Montana. Genetic correlations between treatments 1 and 2, 1 and 3, and 2 and 3 were 0.98, 0.78, and 0.65 and 1.00, 0.98, and 0.99 for precalving and prebreeding BCS, respectively. This provides moderate evidence of genotype-by-environment interactions for precalving BCS under treatment 3 relative to treatments 1 and 2, but no evidence for genotype-by-environment interactions for prebreeding BCS. Treatment 3 differed substantially in CP content relative to treatments 1 and 2, indicating that some animals differ in their ability to maintain BCS up to spring calving across a protein gradient. These results indicate the potential for selection of animals with increased resilience under cold weather conditions and high protein, restricted energy diets to maintain BCS.
Stable water isotopes reveal the onset of bud dormancy in temperate trees, whereas water content is a better proxy for dormancy release
Authors: Walde Manuel G , Wenden Bénédicte , Chuine Isabelle , Gessler Arthur , Saurer Matthias , Vitasse Yann 
Published: February 2024

AbstractEarlier spring growth onset in temperate forests is a visible effect of global warming that alters global water and carbon cycling. Consequently, it becomes crucial to accurately predict the future spring phenological shifts in vegetation under different climate warming scenarios. However, current phenological models suffer from a lack of physiological insights of tree dormancy and are rarely experimentally validated. Here, we sampled twig cuttings of five deciduous tree species at two climatically different locations (270 and 750 m a.s.l., ~ 2.3 °C difference) throughout the winter of 2019–20. Twig budburst success, thermal time to budburst, bud water content and short-term 2H-labelled water uptake into buds were quantified to link bud dormancy status with vascular water transport efficacy, with the objective of establishing connections between the dormancy status of buds and their effectiveness in vascular water transport. We found large differences in the dormancy status between species throughout the entire investigation period, likely reflecting species-specific environmental requirements to initiate and release dormancy, whereas only small differences in the dormancy status were found between the two studied sites. We found strong 2H-labelled water uptake into buds during leaf senescence, followed by a sharp decrease, which we ascribed to the initiation of endodormancy. However, surprisingly, we did not find a progressive increase in 2H-labelled water uptake into buds as winter advanced. Nonetheless, all examined tree species exhibited a consistent relationship between bud water content and dormancy status. Our results suggest that short-term 2H-labelled water uptake may not be a robust indicator of dormancy release, yet it holds promise as a method for tracking the induction of dormancy in deciduous trees. By contrast, bud water content emerges as a cost-effective and more reliable indicator of dormancy release.
Total-evidence phylogeny of the subfamily Cylapinae and the divergence dates for its subgroupings (Insecta: Heteroptera: Miridae)
Authors: Namyatova Anna A , Tyts Veronica D 
Published: February 2024

Abstract
Representatives of the subfamily Cylapinae (Insecta: Heteroptera: Miridae) mostly inhabit the subtropics and tropics. The group currently comprises five tribes: Bothriomirini, Cylapini, Fulviini, Rhinomirini, and Vanniini. Additionally, the Psallopinae are sometimes included in this subfamily as a tribe. The interrelationships within Cylapinae are unknown, the monophyly is doubtful, and a phylogenetic study focusing on the entire subfamily has never been published. The molecular and fossil data analyses show that Miridae occurred at least in the Jurassic. The divergence dates for Cyalpinae tribes are unknown. We performed the phylogenetic analysis of Cylapinae based on molecular and morphological data, in addition to a combined dataset. We calibrated the molecular trees with fossil data. The results suggested non-monophyly of Cylapinae. The monophyly of Bothriomirini was confirmed. Cylapini were rendered as non-monophyletic. The Cylapus complex formed a clade with Vanniini, and the monophyly of Vanniini was doubtful. Fulviini were recovered as non-monophyletic, and the representatives fell into two separate well-supported clades. Dating analyses showed that the groups of the suprageneric level distributed across different continents diverged near the boarder between Mesosoic and Cenosoic, that was also true for the Asian suprageneric groups and the South American Cylapus complex. Australian groups of genera diverged in the Cenozoic.
FilGAP controls cell‐extracellular matrix adhesion and process formation of kidney podocytes
Authors: Saito Koji , Yokawa Seiji , Kurihara Hidetake , Yaoita Eishin , Mizuta Sari , Tada Kanae , Oda Moemi , Hatakeyama Hiroyasu , Ohta Yasutaka 
Published: February 2024

AbstractThe function of kidney podocytes is closely associated with actin cytoskeleton regulated by Rho small GTPases. Loss of actin‐driven cell adhesions and processes is connected to podocyte dysfunction, proteinuria, and kidney diseases. FilGAP, a GTPase‐activating protein for Rho small GTPase Rac1, is abundantly expressed in kidney podocytes, and its gene is linked to diseases in a family with focal segmental glomerulosclerosis. In this study, we have studied the role of FilGAP in podocytes in vitro. Depletion of FilGAP in cultured podocytes induced loss of actin stress fibers and increased Rac1 activity. Conversely, forced expression of FilGAP increased stress fiber formation whereas Rac1 activation significantly reduced its formation. FilGAP localizes at the focal adhesion (FA), an integrin‐based protein complex closely associated with stress fibers, that mediates cell‐extracellular matrix (ECM) adhesion, and FilGAP depletion decreased FA formation and impaired attachment to the ECM. Moreover, in unique podocyte cell cultures capable of inducing the formation of highly organized processes including major processes and foot process‐like projections, FilGAP depletion or Rac1 activation decreased the formation of these processes. The reduction of FAs and process formations in FilGAP‐depleted podocyte cells was rescued by inhibition of Rac1 or P21‐activated kinase 1 (PAK1), a downstream effector of Rac1, and PAK1 activation inhibited their formations. Thus, FilGAP contributes to both cell‐ECM adhesion and process formation of podocytes by suppressing Rac1/PAK1 signaling.
Gallbladder polypoid lesions: Current practices and future prospects
Authors: Wang Kun , Xu Qingpeng , Xia Lu , Sun Jianing , Shen Kanger , Liu Haoran , Xu Linning , Li Rui 
Published: February 2024

Abstract
Gallbladder polypoid lesions (GPLs) refer to any elevated lesion of the mucosal surface of the gallbladder wall, and the prevalence is estimated to be between 0.9% and 12.1%. GPLs include benign polyps and malignant polyps. Benign polyps are further classified as non-neoplastic polyps and neoplastic polyps. Cholesterol polyps are the most common benign polyps and adenocarcinoma is the main type of malignant polyp. Hepatitis B virus infection, liver function abnormalities, dyslipidemia, and obesity are the main risk factors for GPLs. Studies of biological mechanisms have focused on malignant gallbladder polyps, the development of which is regulated by hormone levels in vivo, gut microbiota, inflammation, oxidative stress, Salmonella typhimurium, and related molecules. Diagnostic modalities include chemical examination and imaging examination, with imaging examination currently being the mainstay. Treatment of patients with GPLs is based on the presence or absence of symptoms, age, size of the polyps, tendency of the polyp to increase, and risk factors for symptomatic malignancy to determine whether surgery should be performed.
Histopathological Evaluation of Pouch Neoplasia in Inflammatory Bowel Diseases and Familial Adenomatous Polyposis
Authors: Ko Huaibin Mabel 
Published: February 2024

BACKGROUND:
Ileal pouch-anal anastomosis is often required for patients with ulcerative colitis or familial adenomatous polyposis after colectomy. This procedure reduces but does not completely eliminate the risk of neoplasia.

OBJECTIVE:
This study focuses on the histopathology of neoplasia in the ileal pouch, rectal cuff, and anal transition zone.

DATA SOURCES:
We performed a Medline search for English language studies published between 1981 and 2022 using the PubMed search engine. The terms “ileal pouch-anal anastomosis,” “pouchitis,” “pouch dysplasia,” “pouch lymphoma,” “pouch squamous cell carcinoma,” “pouch adenocarcinoma,” “pouch neoplasia,” “dysplasia of rectal cuff,” and “colitis-associated dysplasia” were used.

STUDY SELECTION:
Human studies of neoplasia occurring in the pouch and para-pouch were selected and the full text was reviewed. Comparisons were made within and across studies, with key concepts selected for inclusion in this manuscript.

CONCLUSIONS:
Neoplasia in the pouch is a rare complication in patients with ileal pouch-anal anastomosis. Annual endoscopic surveillance is recommended for familial adenomatous polyposis patients and UC patients with a history of prior dysplasia or carcinoma. In familial adenomatous polyposis, dysplastic polyps of the pouch are visible and readily amenable to endoscopic removal; however, glandular dysplasia in the setting of ulcerative colitis may be invisible on endoscopy. Therefore random biopsies and adequate tissue sampling of the pouch and rectal cuff are recommended in this setting. The histological diagnosis of inflammatory bowel disease-associated dysplasia can be challenging and should be confirmed by at least one expert gastrointestinal pathologist. See video from symposium.