bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endocrinological and metabolic profile of Gaucher disease patients treated with enzyme replacement therapy
Authors: Kilic Ayse , Emecen Sanli Merve , Ozsaydı Aktasoglu Ekin , Gokalp Sabire , Biberoğlu Gürsel , Inci Aslı , Okur Ilyas , Suheyl Ezgu Fatih , Tumer Leyla 
Published: April 2024

Abstract

Objectives
Gaucher disease (GD) is a lysosomal storage disease caused by glucocerebrosidase (GCase) enzyme deficiency. Gaucher cells transformed from the macrophages by progressive sphingolipid accumulation and infiltrate bone marrow, spleen, liver, and other organs. The accumulation of substrate causes inflammation, compromised cellular homeostasis, and disturbed autophagy. It has been hypothesized that this proinflammatory state of GD leads cytokines and chemokines release. As a result of inflammatory process, the cellular dysfunction caused by disruption of cellular signaling, organelle dysfunction, or autoimmune antibodies may affect endocrine profile of GD patients such as hormone levels, lipid profile, and bone mineral density status.

Methods
A total of 13 patients confirmed to have GD, 12 non-neuronopathic type and one subacute neuronopathic type, were enrolled in our study.

Results
The median treatment duration in the enzyme therapy was 13.33 years (9–26 years). At least one endocrinological abnormality was detected in blood tests of nine patients. Hyperinsulinism was the most common finding although fasting blood glucose levels HgbA1c levels were normal in all patients. Two patients had osteopenia, and osteoporosis was detected in two patients. Low HDL levels were detected in six patients, but HDL levels below 23 mg/dL associated with disease severity have been detected in two patients who have not receiving enzyme replacement therapy. None of patients had thyroidal dysfunction.

Conclusions
This study had revealed endocrinological abnormalities in GD patients that have not led any severe morbidity in our patients. However, thyroid hormone abnormalities, insulin resistance, or lipid profile abnormalities may cause unpredictable comorbidities. Endocrinological assessment in GD patients in routine follow-up may prevent possible clinical manifestation in long term as well as can define efficacy of ERT on endocrine abnormalities.
What’s hidden below definiteness and genitive: on indefinite partitive articles in Romance
Authors: Pinzin Francesco 
Published: April 2024

Abstract
In French, Italian, and other Romance languages indefinite nominal phrases can be introduced by what appears to be the conflation of a genitive preposition and a definite article, the so-called “indefinite partitive articles” (e.g., Fr. Je cuisine de la soupe depuis deux jours. ‘I’ve been cooking soup for two days’). This is rather unexpected, since these nominal phrases are neither definite nor in a syntactic position in which we expect to find a genitive preposition. This led part of the literature to consider them as built by lexical items synchronically distinct from the genitive preposition/definite article but homophonous with them. This contribution shows how a constituent-based approach to the lexicon-syntax interface as nanosyntax, paired with a specific take on the sequence of syntactic functions, can capture their apparently conflicting distribution without stipulating multiple homophonous lexical items. The key factor in this proposal is a revised analysis of the Romance lexical item (LI) for (i) definite articles – linked to a constituent containing not only features of definiteness but also lower indefinite features and higher nominative/accusative case features – and (ii) the genitive preposition DE – linked to a constituent containing not only genitive features but also lower nominative/accusative features. Holding these LIs crosslinguistically stable, the variation attested in this domain is modeled as depending on the amount of functional structure lexicalized by the nominal root in the different languages.
Soliton dynamics of the KdV–mKdV equation using three distinct exact methods in nonlinear phenomena
Authors: Ullah M. Atta , Rehan Kashif , Perveen Zahida , Sadaf Maasoomah , Akram Ghazala 
Published: April 2024

Abstract
The KdV–mKdV equation is investigated in this study. This equation is a useful tool to model many nonlinear phenomena in the fields of fluid dynamics, quantum mechanics, and soliton wave theory. The exact soliton solutions of the KdV–mKdV equation are extracted using three distinct exact methods, namely, the generalized projective Riccati equation method, the modified auxiliary equation method, and the generalized unified method. Many novel soliton solutions, including kink, periodic, bright, dark, and singular dark–bright soliton solutions, are obtained. Rational functions, exponential functions, trigonometric functions, and hyperbolic functions are contained in the acquired nontrivial exact solutions. The graphical simulation of some obtained solutions is depicted using 3D plots, 2D contour plots, density plots, and 2D line plots. For the first time, the KdV–mKdV equation is investigated using the proposed three exact methods, and many novel solutions, such as dark, bright, and dark–bright singular soliton solutions, are determined, which have never been reported in the literature.
Investigation of the lubrication performance of a marine diesel engine crankshaft using a thermo-electrohydrodynamic model
Authors: Xu Yanming , Teng Xianbin 
Published: April 2024

Abstract
This study outlines the development of a three-dimensional model for the crankshaft-bearing and a multi-body dynamics model for a four-stroke marine diesel engine. The models are constructed through a simulation approach that integrates the finite element method and multi-body dynamics method. Additionally, the Greenwood/Tripp asperity contact theory and average flow model are incorporated. The investigation also delves into the dynamic coupling between the crankshaft-bearing multi-body system and the mixed lubrication effects, accounting for lubricating oil as a thermo-electrohydrodynamic model and the journal as an elastomer. The study meticulously examines the lubrication characteristics of main bearings in marine diesel engines during normal operational conditions and scrutinizes the impact of various parameters on crankshaft-bearings. The study concludes by offering recommendations and technical support for innovative optimization design and model enhancement of diesel engine crankshaft-bearings.
Erholung wirkt ansprechender als Gesundheit – Anregungen für die Angebotskommunikation von Gesundheitsdestinationen
Authors: Hürten Dennis , Kimmich Katharina 
Published: April 2024

Zusammenfassung
Eine wichtige Aufgabe der Heilbäder und Kurorte Marketing GmbH Baden-Württemberg besteht darin, die höher prädikatisierten Orte Baden-Württembergs als zeitgemäße Gesundheitsdestinationen zu vermarkten. Um dieses Ziel zu erreichen, wurde in den Jahren 2019 bis 2022 eine marktforschungsbasierte Strategie entwickelt. Diese sieht vor, den Gesundheitstourismus in Baden-Württemberg zweigleisig anhand der Themen ‚Gesundheit‘ und ‚Erholung‘ zu positionieren. Aus diesem Grund stellte sich die Frage, inwiefern die Kundenansprache bezüglich dieser beiden Makrosegmente künftig differenziert werden sollte. Zur Beantwortung dieser Frage wurde im Jahr 2022 eine quantitative Marktforschungsstudie durchgeführt, in der die aktuelle Angebotskommunikation (Begriffe, Slogans, Werbebilder und Werbeanzeigen) hinsichtlich der beiden zuvor genannten Themen miteinander verglichen wurde. Die Ergebnisse der Studie legen den Schluss nahe, dass dem Thema ‚Erholung‘ für die Kundenansprache insgesamt eine höhere Eignung zukommt als dem Thema ‚Gesundheit‘.
SORPTION OF PETROLEUM PRODUCTS BY MODIFIED SAMPLES OF WATER TREATMENT WASTE
Authors: Shumkova Irina N. , Sanatullova Zemfira T. , Shaikhiev Ildar G. , Sverguzova Svetlana V. 
Published: April 2024

The possibility of utilizing native waste from drinking water treatment as an absorbent material for petroleum products (motor oil grade 5W-40, diesel fuel, gasoline grade A-92) has been investigated. The mineralogical composition of the water treatment waste has been determined, according to the results, it primarily consists of quartz, calcite, sepiolite, anorthite, and gallwazite. Values of the maximum absorption capacity for the investigated petroleum products and the maximum water absorption have been established. To reduce water absorption properties, the native material have been modified by thermal treatment at a temperature of 550 °C, treatment with 5 % solutions of sulfuric acid and sodium hydroxide, as well as a 5 % solution of silicone fluid of the «Ecodom Bio» brand. Values of the maximum absorption capacity of the modified water treatment waste for petroleum products and water under static and dynamic conditions also have been determined. It has been revealed that thermal treatment contributes to achieving maximum absorption capacity values for both petroleum products and water absorption. It has been established that the minimal water absorption is observed in the sample of the investigated material treated with a siliconorganic fluid solution. Purification of liquids containing hydrocarbons at a concentration of 2 mg/dm3 in dynamic conditions has been carried out. Overall, it has been determined that the maximum solution purification is observed for motor oil, and the minimal one – for gasoline grade A-92.
Optimizing Foundations: The Case for Slab Selection in Multi-Story Residential Buildings
Authors: Nargul Saktaganova , Saken Uderbayev , Akmaral Zhapakhova , Gulnaz Zhakapbayeva , Gulaina Aben , Alina Yespenbetova 
Published: April 2024

This study investigates the optimal foundation design for multi-story residential buildings through a comparative analysis of two foundation variants under specific geological conditions. Employing the finite element method via SCAD software, we assessed the structural integrity and load-bearing capacities of the foundation options. Material consumption was quantified for each variant, and the consistency of settling calculations for the slab foundation was evaluated. The results indicated that the slab foundation not only minimizes material usage but also simplifies design complexity according to normative standards. Based on technical and economic assessments, the slab foundation is recommended as the most cost-effective and structurally efficient option for such construction projects. This research provides a pivotal foundation design perspective that could influence future architectural and engineering practices in residential building construction.
Highlights:

SCAD software validates foundation integrity via finite element analysis.
Slab foundations offer superior cost and material efficiency.
Simplifies design, enhancing construction process efficiency.

Keywords: Structural Integrity, Slab Foundation, Reinforcement, Monolith, Building
Investigation on the Influence of Electrolytic Milling Machining Parameters on the Machining Accuracy of Thin-walled Parts
Authors: Hou Junming , Wang Baosheng , Lv Dongsheng , Xu Changhong 
Published: April 2024

Abstract

In order to reduce the weight of aircraft parts, they are often designed as thin-walled structures and the thin-walled structure will deform when the cutting force is generated and applied to the thin-walled parts for its poor rigidity. So the machining accuracy of thin-walled parts will be reduced for the deformation in milling process. Then, the electrolytic milling method composed of milling and electrochemical machining is proposed to reduce workpiece deformation and improve machining accuracy of thin-walled parts. The machining parameters of milling method and electrochemical machining method, which connected with the material removal thickness and machining accuracy, are analysed. The machining parameters, which contain spindle speed, feed rate, voltage, electrolyte concentration, are selected and the machining accuracy measuring experiments are implemented. And the machining accuracy predicting model of thin-walled parts is established on the basis of electrolytic milling experimental results. The effects of milling parameters and electrochemical machining parameters on material removal thickness are studied separately. In addition, the accuracy predicting model is also validated by electrolytic milling experiments. The results show that the machining accuracy of electrochemical milling is superior to that of milling. It is a composite machining method that combines the advantages of electrochemical machining and milling.
The Tmem16a chloride channel is required for mucin maturation after secretion from goblet-like cells in the Xenopus tropicalis tadpole skin.
Authors: Dubaissi Eamon , Emma Hilton , Lilley Sarah , Collins Richard , Danahay Henry , Gosling Martin , Grencis Richard , Roberts Ian , Thornton David 
Published: April 2024

Abstract

The TMEM16A chloride channel is proposed as a therapeutic target in cystic fibrosis, where activation of this ion channel might restore airway surface hydration and mitigate respiratory symptoms. While TMEM16A is associated with increased mucin production under stimulated or pro-inflammatory conditions, its role in baseline mucin production, secretion and/or maturation is less well understood. Here, we use the Xenopus tadpole skin mucociliary surface as a model of human upper airway epithelium to study Tmem16a function in mucus production. We found that Xenopus tropicalis Tmem16a is present at the apical membrane surface of tadpole skin small secretory cells that express canonical markers of mammalian “goblet cells” such as Foxa1 and Spdef. X. tropicalis Tmem16a functions as a voltage-gated, calcium-activated chloride channel when transfected into mammalian cells in culture. Depletion of Tmem16a from the tadpole skin results in dysregulated mucin maturation post-secretion, with secreted mucins having a disrupted molecular size distribution and altered morphology assessed by sucrose gradient centrifugation and electron microscopy, respectively. Our results show that in the Xenopus tadpole skin Tmem16a is necessary for normal mucus barrier formation and demonstrate the utility of this model system to discover new biology relevant to human mucosal biology in health and disease.
Strong asymptotic giant branch stars’ spectral features in distant quiescent galaxies: Impact on galaxy evolution
Authors: LU Shiying , Daddi Emanuele , Maraston Claudia , Dickinson Mark , Haro Pablo Arrabal , Gobat Raphaël , Renzini Alvio , Giavalisco Mauro , Bagley Micaela , Calabrò Antonello , Cheng Yingjie , Vega Alexander de la , D'Eugenio Chiara , Elbaz David , Finkelstein Steven , Gómez-Guijarro Carlos , Gu Qiusheng , Hathi Nimish , Huertas-Company Marc , Kartaltepe Jeyhan , Koekemoer Anton , Bail Aurélien Le , Lyu Yipeng , Magnelli Benjamin , Mobasher Bahram , Papovich Casey , Pirzkal Norbert , Rich R. Michael , Tacchella Sandro , Yung L. Y. Aaron 
Published: April 2024

Abstract

Age-dating and weighting stellar populations in galaxies at various cosmic epochs are essential steps to study galaxy formation through cosmic times. Evolutionary population synthesis models with different input physics are used towards this aim. In particular, the contribution from the thermally pulsing asymptotic-giant-branch (TP-AGB) stellar phase, which peaks for intermediate-age 0.6-2 Gyr systems, has been debated upon for decades. Here we report the detection of strong cool star signatures in the rest-frame near-infrared spectra of three young (~1 Gyr), massive (~10^10 Msun) quiescent galaxies at large look-back time, z=1-2, using JWST/NIRSpec. The co-existence of oxygen- and carbon-type absorption features, spectral edges and features from rare species such as Vanadium, and possibly Zirconium, reveal a strong contribution from TP-AGB stars. Population synthesis models with significant TP-AGB contribution reproduce the observations considerably better than those with weak TP-AGB, which are those commonly used. These findings call for revisions of published stellar population fitting results, pointing to lower masses and younger ages, with additional implications on cosmic dust production and chemical enrichment. These results will stimulate new generations of improved models informed by these and future observations.
Thickness Thinning and Transition Zone Movement of Tailor Rolled Blank under Different Blank Holder Force Modes
Authors: ZHANG Huawei , WU Jia-lu , GONG Yong-zhen , WANG Xin-gang 
Published: April 2024

Abstract

Tailor Rolled Blank(TRB) demonstrates great potential in the field of automotive lightweight, and thus the research on the formability of TRB is of high practical value. In this paper, the formability of Tailor Rolled Blank under different blank holder force(BHF) modes was studied through numerical simulations and stamping experiments by taking square box as the research object. The effects of BHF value and BHF type on the formability of TRB were analyzed, and the thickness thinning and the thickness transition zone(TTZ) movement for TRB part under different BHF modes were discussed. The findings indicate that the blank hold force plays an important role in the forming process of TRB. The segmented blank holder and the stepped mould gap adjustment plate can provide different blank hold forces and a uniform blank holding gap for the thinner side and the thicker side. Constant BHF and higher BHF value on the thinner side than that on the thicker side(4 tons on the thinner side and 2 tons on the thicker side) independent of time are advantageous to improving the formability of TRB.
WITHDRAWN: Impact of SMOFlipid Emulsion Integration in Total Parenteral Nutrition on Inpatient Outcomes and Economic Burden for Preterm Neonates: A Retrospective Cohort Study
Authors: Refaay Mohamed Emad Eldin , Yassine Omaima Gaber Mohamed , Abu-Sheasha Ghada Ahmad , Sayed Prof. Dr. Adel Zaki Abdel 
Published: April 2024

Abstract
The full text of this preprint has been withdrawn by the authors since they no longer stand by the findings/conclusions of this work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Deciphering genotype performance, genotype and environment interaction of seed cotton yield and ginning outturn using GGE biplot for selection of Gossypium hirsutum for rainfed ecosystem
Authors: Subbarayan Sivakumar , K Bharathi Kumar , P Anantharaju , K Thiyagu , A Manivannan , Banoth Madhu 
Published: April 2024

Abstract

Background
Cotton is mostly grown under rainfed condition by small and marginal farmers and provides economic livelihood. The assessment of adaptability of a suitable genotype is important and therefore, multilocation evaluation of genotypes was conducted at eight agro-ecologically diverse environments under rainfed ecosystems in India. The data was analyzed for key biometrical traits using pooled ANOVA, LSD test, correlation matrices and regression analysis over two years (2019-20). Additionally, we employed genotype plus genotype by environment interaction (GGE) biplot analysis to identify winning genotypes across different environments.
Results
The results showed that genotype, environment and their interaction (GEI) significantly (p < 0.01) influenced SCY and GOT%. The GEI showed a high significant impact on SCY (40.46%) and GOT% (48.86%) among genotypes. Correlation analysis revealed positive associations between SCY and major yielding traits such as boll weight, ginning outturn and lint yield. Regression analysis demonstrated that a combination of these traits contributed to high stable yield over the years across the rainfed conditions. The total variation in SCY was 96.61%, composed of PC1 and PC2 values at 92.06% and 4.55%, respectively. GGE biplot analysis identified the genotypes viz., NDLH2057-1, TVH007, and NH615 exhibited high yield potential and ginning outturn and high stability across multilocations. The average environment axis (AEA) of the biplot identified most representative location for the yield and GOT%, respectively.
Conclusion
The findings identified the use of optimal genotypes for cultivation and use of such genotypes for trait introgression in future breeding and crop improvement, which may facilitate genetic gain of yielding traits and ginning outturn in rainfed environments.
Flood Susceptibility Modelling by Advanced Convolutional Neural Networks (CNN) in the foothills of Southern Western Ghats, Kerala, India
Authors: Kandpal Umashankar , Sharma Rajat Kr , Roy Arka , Sreel K , Kundapura Subrahmanya 
Published: April 2024

Abstract

The intensity and frequency of extreme events have increased significantly in the past few years due to climate change, leading to more severe and devastating floods worldwide. In India, Kerala state has witnessed the most catastrophic floods of the century in the past five years. Thus, accurate flood susceptibility models are required for effective risk assessment and disaster management. In the present study, Machine Learning-based flood susceptibility models are developed for one of the severely affected districts, Kottayam, in the foothills of the Southern Western Ghats of Kerala state in India. The performance of SVM, tree-based XGBOOST, and Deep-Learning CNN models have been evaluated in flood susceptibility modelling. The performance of candidate models is evaluated using the Area Under the Curve of the Receiver Operating Characteristic curve (AUC-ROC). The models are validated using Overall accuracy, Precision, Recall, Specificity, and F1- score. CNN model outperformed SVM and XGBOOST. The AUC - ROC for SVM, XGBOOST, and CNN is 0.96, 0.97, and 0.99, respectively. The flood susceptibility model developed in the present study will be helpful in better disaster preparedness and the development of tailored flood mitigation plans, which would eventually reduce the impact of floods in the coming years.
Impact of Psychological Entitlement on Engagement in Learning Activities and Psychological Anxiety of Hotel Employees: Envy as an Explanatory Mechanism
Authors: Irshad Muhammad , Majeed Mehwish , FARID TAHIR , Basahal Abdulrahman S , Iqbal Sadaf , Yaqub Muhammad Zafar 
Published: April 2024

Abstract

A personality trait, "psychological entitlement," has appeared as a significant field of research. The present study aimed to investigate the impact of psychological entitlement on engagement in learning activities and psychological anxiety in the hotel industry. Furthermore, benign and malign envy were examined as an explanatory mechanism between psychological entitlement and its outcomes. Based on a three-wave time-lagged design, data were obtained from 242 employees working in the different hotels in Pakistan. We found that psychological entitlement's has no direct influence on hotel employees engagement in learning activities, and psychological anxiety. In addition, the indirect effect of psychological entitlement on both outcomes (engagement in learning activities and psychological anxiety) was found significant through the mediating effect of benign and malign envy. The implications for research theory and practice are discussed.