bluuebunny/crossref_metadata_2025_split huggingface dataset:
Living in a Fish Bowl or Not? The Role of Transparency and Privacy in Creative Dialogues on Enterprise Social Media
Authors: Osch Wietske Van , Bulgurcu Burcu , Liang Yuyang 
Published: April 2024

<p>Transparency—the observability of activities, behaviors, and performance—has become the panacea of modern management. Yet, there is a conundrum in the literature with some studies suggesting transparency and others suggesting privacy may benefit group creativity. A similar conundrum exists regarding the effects of different social capital types—structural holes versus network cohesion on group creativity. Enterprise Social Media (ESM) provide a unique opportunity to solve these conundrums by allowing groups to be “transparent”— non-group members can observe and/or participate in group activities—or “private”— group members and activities are hidden from the community—and enabling groups to develop distinct social capital structures. Using data from 28,083 written interactions produced by 109 transparent and 106 private groups in an ESM of a multinational design firm, we find strong support for our contingency hypotheses that both transparent and private groups may produce high levels of creative dialogues, yet, in different forms. Specifically, expansion-focused creative dialogues—those focused on combining or expanding existing concepts—emerge in transparent groups, but only when the group’s social capital is characterized by structural holes. Conversely, reframing-focused dialogues—those focused on challenging and rethinking—emerge in private groups, but only when the group’s social capital is characterized by network cohesion. Theoretically, these findings help solve the conundrums in the literature on group creativity and shed light on the role of ESM use in this context. Practically, our findings offer a critical reflection onto contemporary initiatives for increasing transparency, whether through physical design or digital transformation. </p>
Open Your Eyes: Teaching and Learning about Anti-Asian Racism and the Law in Canada
Authors: Lee Angela 
Published: April 2024

<p>Recently, policymakers, institutional actors, and the public have made greater efforts towards being attentive to issues relating to anti-racism and discrimination, as well as equity, diversity, and inclusion more broadly, prompted in part by growing calls for reconciliation with Indigenous peoples and the increasing visibility of the Black Lives Matter movement. Yet, there has been a relative dearth of attention paid to the specific ways in which anti-Asian racism manifests and is maintained, particularly in the Canadian context. More than just being a relic of the past, anti-Asian racism is an ongoing phenomenon both within and beyond Canada’s borders, as events in the wake of the COVID-19 pandemic have painfully demonstrated. </p>
<p>This article identifies some of the ways that laws and policies have contributed and continue to contribute to the oppression of Asian people in Canada. It considers the role of legal education in both perpetuating and addressing systemic racism, especially vis-à-vis Critical Race Theory and the recent backlash against it and argues that members of the legal profession—and by extension, the law schools that educate them—have a professional and moral responsibility to take seriously the historic and contemporary experiences of exclusion to which all marginalized groups have been subjected. In so doing, it emphasizes the importance of understanding various struggles for racial justice as profoundly interconnected and inseparable, but also distinct. </p>
Business Improvement Areas and Tourism in Urban Neighbourhoods
Authors: Griffin Tom 
Published: April 2024

<p> Tourism is a vast phenomenon, with substantial economic, social, and environmental impacts for travellers, residents, businesses, and communities (Mason, 2015). Much attention is given to urban destination marketing (e.g. Papadimitriou, Apostolopoulou, & Kaplanidou, 2015), and tourism’s potential for economic and social development in rural or developing world communities (e.g. Lane & Kastenholz, 2015). However, the existing and potential role of tourism in urban residential neighbourhoods has received limited attention. Business Improvement Areas (BIAs) are “association[s] of business people within a specified district, who join together, with official approval of the City… aimed at stimulating local business… [serving] as an economic and social anchor, helping to stabilize and revitalize the local community” (TABIA, 2018b). There are 82 BIAs across Toronto’s diverse neighbourhoods, and many more across the province and country (OBIAA, 2018). However, despite their number, there is limited research on BIAs in general, and specifically on tourism (Ward, 2006). The purpose of this exploratory study, therefore, is to explore and understand BIAs’ roles and actions relating to tourism such as product development, marketing, management, and socio-cultural and economic implications, drawing from interviews with 30 BIAs in Toronto. </p>
Review of the scientific publication “Kunts E. V. Minors as an object of criminological and criminal law study : monograph. Chelyabinsk : A. Miller Library, 2021. 162 with"
Authors: Shamsunov Salikh 
Published: April 2024

The article presents a review of the monograph by E. V. Kunts, Doctor of Law, Professor, Honorary Worker of Higher Professional Education of the Russian Federation, leading researcher of the Research Institute of the Federal Penitentiary Service of Russia,
«Minors as an object of criminological and criminal law study». The monograph is devoted to the actual problem of studying minors from the standpoint of domestic sciences of criminology and criminal law. Special attention is paid to criminological analysis of illegal and antisocial behavior of minors, its prevention and prevention, issues of sentencing and release of a minor from criminal punishment. Normative and empirical material is presented, which supports the formulated theoretical conclusions. In general, the author of the article comes to the conclusion that the reviewed monograph is a complete and comprehensive study, meets the requirements and is recommended for publication.
Collagen molecular organization preservation in human fascia lata and periosteum after tissue engineering
Authors: Vettese Julia , Manon Julie , Chretien Antoine , Evrard Robin , Fievé Lies , Schubert Thomas , Lengelé Benoît G. , Behets Catherine , Cornu Olivier 
Published: April 2024

Large bone defect regeneration remains a major challenge for orthopedic surgeons. Tissue engineering approaches are therefore emerging in order to overcome this limitation. However, these processes can alter some of essential native tissue properties such as intermolecular crosslinks of collagen triple helices, which are known for their essential role in tissue structure and function. We assessed the persistence of extracellular matrix (ECM) properties in human fascia lata (HFL) and periosteum (HP) after tissue engineering processes such as decellularization and sterilization. Harvested from cadaveric donors (N = 3), samples from each HFL and HP were decellularized following five different chemical protocols with and without detergents (D1-D4 and D5, respectively). D1 to D4 consisted of different combinations of Triton, Sodium dodecyl sulfate and Deoxyribonuclease, while D5 is routinely used in the institutional tissue bank. Decellularized HFL tissues were further gamma-irradiated (minimum 25 kGy) in order to study the impact of sterilization on the ECM. Polarized light microscopy (PLM) was used to estimate the thickness and density of collagen fibers. Tissue hydration and content of hydroxyproline, enzymatic crosslinks, and non-enzymatic crosslinks (pentosidine) were semi-quantified with Raman spectroscopy. ELISA was also used to analyze the maintenance of the decorin (DCN), an important small leucine rich proteoglycan for fibrillogenesis. Among the decellularization protocols, detergent-free treatments tended to further disorganize HFL samples, as more thin fibers (+53.7%) and less thick ones (−32.6%) were recorded, as well as less collagen enzymatic crosslinks (−25.2%, p = 0.19) and a significant decrease of DCN (p = 0.036). GAG content was significantly reduced in both tissue types after all decellularization protocols. On the other hand, HP samples were more sensitive to the D1 detergent-based treatments, with more disrupted collagen organization and greater, though not significant loss of enzymatic crosslinks (−37.4%, p = 0.137). Irradiation of D5 HFL samples, led to a further and significant loss in the content of enzymatic crosslinks (−29.4%, p = 0.037) than what was observed with the decellularization process. Overall, the results suggest that the decellularization processes did not significantly alter the matrix. However, the addition of a gamma-irradiation is deleterious to the collagen structural integrity of the tissue.
Geochemical characteristics of rare earth elements in late Palaeozoic coals from North China
Authors: Wen Long , Huang Wenhui , Zhang Yuanfu , Jiu Bo 
Published: April 2024

Introduction: China is a large country of REE resources and production, supplying more than 90% of the world’s rare earth consumption market, China’s traditional REE resources, although rich, but reserves are also declining, in recent years, scholars have shown that the REEs in the specific geological conditions in the coals can be enriched, and even reach the industrial grade, the search for more REE mineral resources will be of great strategic significance.Methods: The article has selected the Zibo, Taozao, Huainan, Datong, Huozhou, Jungar, and Weibei coalfields in North China as the research objects. Based on inductively coupled plasma mass spectrometry (ICP-MS) analyses, the study provides a detailed analysis of the enrichment rules and distribution patterns of rare earth elements (REEs) in coal under different geological conditions.Results: The REE distribution patterns in Late Palaeozoic coals in North China are characterized by enrichment of LREEs, deficit of HREEs with gentle changes, and obvious negative anomalies of Eu, the enrichment of REE in coal is controlled by provenance and volcanism, and is related to distance of transport terrigenous material and the sedimentary environment. The REEs concentrations in North China indicates that Late Palaeozoic coals in the mining areas of the north, northwest, and western parts of North China are significantly enriched in REEs. In addition, REEs in Late Palaeozoic coals in the southeastern mining areas are relatively enriched, and the central and eastern regions are significantly depleted.Discussion: Large coal-type rare earth deposits are expected to be developed in North China, particularly the Datong coalfield, Jungar coal mine and the Weibei coal mine in the eastern margin of the Ordos Basin, and the Zibo coalfield.
Boosting the immunogenicity of the CoronaVac SARS-CoV-2 inactivated vaccine with Huoxiang Suling Shuanghua Decoction: a randomized, double-blind, placebo-controlled study
Authors: Tang Ruying , Wang Linyuan , Zhang Jianjun , Fei Wenting , Zhang Rui , Liu Jinlian , Lv Meiyu , Wang Mengyao , Lv Ruilin , Nan Haipeng , Tao Ran , Chen Yawen , Chen Yan , Jiang Yanxin , Zhang Hui 
Published: April 2024

IntroductionIn light of the public health burden of the COVID-19 pandemic, boosting the safety and immunogenicity of COVID-19 vaccines is of great concern. Numerous Traditional Chinese medicine (TCM) preparations have shown to beneficially modulate immunity. Based on pilot experiments in mice that showed that supplementation with Huoxiang Suling Shuanghua Decoction (HSSD) significantly enhances serum anti-RBD IgG titers after inoculation with recombinant SARS-CoV-2 S-RBD protein, we conducted this randomized, double-blind, placebo-controlled clinical trial aimed to evaluate the potential immunogenicity boosting effect of oral HSSD after a third homologous immunization with Sinovac’s CoronaVac SARS-CoV-2 (CVS) inactivated vaccine.MethodsA total of 70 participants were randomly assigned (1:1 ratio) to receive a third dose of CVS vaccination and either oral placebo or oral HSSD for 7 days. Safety aspects were assessed by recording local and systemic adverse events, and by blood and urine biochemistry and liver and kidney function tests. Main outcomes evaluated included serum anti-RBD IgG titer, T lymphocyte subsets, serum IgG and IgM levels, complement components (C3 and C4), and serum cytokines (IL-6 and IFN-γ). In addition, metabolomics technology was used to analyze differential metabolite expression after supplementation with HSSD.ResultsFollowing a third CVS vaccination, significantly increased serum anti-RBD IgG titer, reduced serum IL-6 levels, increased serum IgG, IgM, and C3 and C4 levels, and improved cellular immunity, evidenced by reduce balance deviations in the distribution of lymphocyte subsets, was observed in the HSSD group compared with the placebo group. No serious adverse events were recorded in either group. Serum metabolomics results suggested that the mechanisms by which HSSD boosted the immunogenicity of the CVS vaccine are related to differential regulation of purine metabolism, vitamin B6 metabolism, folate biosynthesis, arginine and proline metabolism, and steroid hormone biosynthesis.ConclusionOral HSSD boosts the immunogenicity of the CVS vaccine in young and adult individuals. This trial provides clinical reference for evaluation of TCM immunomodulators to improve the immune response to COVID-19 vaccines.
C-reactive protein-complement factor H axis as a biomarker of activity in early and intermediate age-related macular degeneration
Authors: Giralt Lena , Figueras-Roca Marc , Eguileor Beatriz De Luis , Romero Barbara , Zarranz-Ventura Javier , Alforja Socorro , Santiago Francisca , Bolaños Jennifer , Lozano Francisco , Dotti-Boada Marina , Sala-Puigdollers Anna , Dura Paula , Izquierdo-Serra Jordi , Valero Oliver , Adan Alfredo , Fonollosa Alex , Molins Blanca 
Published: April 2024

PurposeTo determine and compare the serum levels of complement Factor H (FH), monomeric C-Reactive Protein (mCRP) and pentameric C-Reactive protein (pCRP) in patients with age-related macular degeneration (AMD) and to correlate them with clinical, structural and functional parameters.MethodsCross-sectional observational study. One hundred thirty-nine individuals (88 patients and 51 healthy controls) from two referral centers were included and classified into three groups: early or intermediate AMD (n=33), advanced AMD (n=55), and age and sex matched healthy controls (n=51). Serum levels of FH, mCRP, and pCRP were determined and correlated with clinical and imaging parameters.ResultsPatients with intermediate AMD presented FH levels significantly lower than controls [186.5 (72.1-931.8) µg/mL vs 415.2 (106.1-1962.2) µg/mL; p=0.039] and FH levels &lt;200 µg/mL were associated with the presence of drusen and pigmentary changes in the fundoscopy (p=0.002). While no differences were observed in pCRP and mCRP levels, and mCRP was only detected in less than 15% of the included participants, women had a significantly higher detection rate of mCRP than men (21.0% vs. 3.8%, p=0.045). In addition, the ratio mCRP/FH (log) was significantly lower in the control group compared to intermediate AMD (p=0.031). Visual acuity (p&lt;0.001), macular volume (p&lt;0.001), and foveal thickness (p=0.034) were significantly lower in the advanced AMD group, and choroidal thickness was significantly lower in advanced AMD compared to early/intermediate AMD (p=0.023).ConclusionIntermediate AMD was associated in our cohort with decreased serum FH levels together with increased serum mCRP/FH ratio. All these objective serum biomarkers may suggest an underlying systemic inflammatory process in early/intermediate AMD patients.
TGF-β mRNA levels in circulating extracellular vesicles are associated with response to anti-PD1 treatment in metastatic melanoma
Authors: Crucitta Stefania , Cucchiara Federico , Marconcini Riccardo , Bulleri Alessandra , Manacorda Simona , Capuano Annalisa , Cioni Dania , Nuzzo Amedeo , de Jonge Evert , Mathjissen Ron H. J. , Neri Emanuele , van Schaik Ron H. N. , Fogli Stefano , Danesi Romano , Del Re Marzia 
Published: April 2024

Introduction: Immune checkpoint inhibitors (ICIs) represent the standard therapy for metastatic melanoma. However, a few patients do not respond to ICIs and reliable predictive biomarkers are needed.Methods: This pilot study investigates the association between mRNA levels of programmed cell death-1 (PD-1) ligand 1 (PD-L1), interferon-gamma (IFN-γ), and transforming growth factor-β (TGF-β) in circulating extracellular vesicles (EVs) and survival in 30 patients with metastatic melanoma treated with first line anti-PD-1 antibodies. Blood samples were collected at baseline and RNA extracted from EVs; the RNA levels of PD-L1, IFN-γ, and TGF-β were analysed by digital droplet PCR (ddPCR). A biomarker-radiomic correlation analysis was performed in a subset of patients.Results: Patients with high TGF-β expression (cut-off fractional abundance [FA] &gt;0.19) at baseline had longer median progression-free survival (8.4 vs. 1.8 months; p = 0.006) and overall survival (17.9 vs. 2.63 months; p = 0.0009). Moreover, radiomic analysis demonstrated that patients with high TGF-β expression at baseline had smaller lesions (2.41 ± 3.27 mL vs. 42.79 ± 101.08 mL, p &lt; 0.001) and higher dissimilarity (12.01 ± 28.23 vs. 5.65 ± 8.4; p = 0.018).Discussion: These results provide evidence that high TGF-β expression in EVs is associated with a better response to immunotherapy. Further investigation on a larger patient population is needed to validate the predictive power of this potential biomarker of response to ICIs.
Astrocyte activation in hindlimb somatosensory cortex contributes to electroacupuncture analgesia in acid-induced pain
Authors: Ye Qing , Li Jie , Ren Wen-Jing , Zhang Ying , Wang Tao , Rubini Patrizia , Yin Hai-Yan , Illes Peter , Tang Yong 
Published: April 2024

BackgroundSeveral studies have confirmed the direct relationship between extracellular acidification and the occurrence of pain. As an effective pain management approach, the mechanism of electroacupuncture (EA) treatment of acidification-induced pain is not fully understood. The purpose of this study was to assess the analgesic effect of EA in this type of pain and to explore the underlying mechanism(s).MethodsWe used plantar injection of the acidified phosphate-buffered saline (PBS; pH 6.0) to trigger thermal hyperalgesia in male Sprague–Dawley (SD) rats aged 6–8 weeks. The value of thermal withdrawal latency (TWL) was quantified after applying EA stimulation to the ST36 acupoint and/or chemogenetic control of astrocytes in the hindlimb somatosensory cortex.ResultsBoth EA and chemogenetic astrocyte activation suppressed the acid-induced thermal hyperalgesia in the rat paw, whereas inhibition of astrocyte activation did not influence the hyperalgesia. At the same time, EA-induced analgesia was blocked by chemogenetic inhibition of astrocytes.ConclusionThe present results suggest that EA-activated astrocytes in the hindlimb somatosensory cortex exert an analgesic effect on acid-induced pain, although these astrocytes might only moderately regulate acid-induced pain in the absence of EA. Our results imply a novel mode of action of astrocytes involved in EA analgesia.
Nano-pulling stimulates axon regeneration in dorsal root ganglia by inducing stabilization of axonal microtubules and activation of local translation
Authors: Falconieri Alessandro , Folino Pietro , Da Palmata Lorenzo , Raffa Vittoria 
Published: April 2024

IntroductionAxonal plasticity is strongly related to neuronal development as well as regeneration. It was recently demonstrated that active mechanical tension, intended as an extrinsic factor, is a valid contribution to the modulation of axonal plasticity.MethodsIn previous publications, our team validated a the “nano-pulling” method used to apply mechanical forces to developing axons of isolated primary neurons using magnetic nanoparticles (MNP) actuated by static magnetic fields. This method was found to promote axon growth and synaptic maturation. Here, we explore the use of nano-pulling as an extrinsic factor to promote axon regeneration in a neuronal tissue explant.ResultsWhole dorsal root ganglia (DRG) were thus dissected from a mouse spinal cord, incubated with MNPs, and then stretched. We found that particles were able to penetrate the ganglion and thus become localised both in the somas and in sprouting axons. Our results highlight that nano-pulling doubles the regeneration rate, and this is accompanied by an increase in the arborizing capacity of axons, an accumulation of cellular organelles related to mass addition (endoplasmic reticulum and mitochondria) and pre-synaptic proteins with respect to spontaneous regeneration. In line with the previous results on isolated hippocampal neurons, we observed that this process is coupled to an increase in the density of stable microtubules and activation of local translation.DiscussionOur data demonstrate that nano-pulling enhances axon regeneration in whole spinal ganglia exposed to MNPs and external magnetic fields. These preliminary data represent an encouraging starting point for proposing nano-pulling as a biophysical tool for the design of novel therapies based on the use of force as an extrinsic factor for promoting nerve regeneration.
Case Report: A developmental and epileptic encephalopathy 45 due to de novo variant of GABRB1
Authors: Wang Lu , Xu Haiquan , Shu Jianbo , Yan Dandan , Li Dong , Cai Chunquan 
Published: April 2024

BackgroundThe gamma-aminobutyric acid (GABA) variant causes developmental and epileptic encephalopathy 45 (DEE45), an autosomal dominant disorder that results in oculocortical visual impairment, reduced muscle tone, psychomotor retardation, and epilepsy. Analysis of the clinical features and genetics of DEE45 may be helpful in complementing genotype-phenotype studies.Case presentationWe collected peripheral blood samples from the affected children and parents and extracted genomic DNA. Whole exome sequencing (WES) was utilized to identify the underlying disease-causing variant. WES showed that the prior carried a heterozygous variant c.686C &gt; T p.(Ala229Val) in exon 7 of the GABRB1 (NM_000812.4), and no variant was detected in either parental sample. The child has DEE45.ConclusionThe variant c.686C &gt; T of the GABRB1 is a possible cause of DEE45. Gene variant analysis of the relevant family lines using WES provides effective genetic counseling for developing and regressing such patients in the clinic. However, further studies are needed to verify the pathogenic mechanism.