bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recherche d’un traitement de conservation du cinabre contre son noircissement : cas des peintures murales de la maison d’Aiôn (Arles, iie-iiie siècles ap. J.-C.)
Authors: Seauve Théa de , Rapilliard Marion , Martinet Gilles , Martin Aurélie , Vallet Jean-Marc 
Published: March 2024

Le cinabre (HgS) est un pigment rouge utilisé dans les fresques de la maison d’Aiôn (Arles, fin du iie siècle). Une fois sorties de fouille et exposées à la lumière, les peintures contenant du cinabre tendent à noircir avec le temps. Un suivi photographique et spectrocolorimétrique de fragments issus de ces peintures murales a montré qu’ils noircissent en quelques mois à la lumière ambiante. Le noircissement, analysé en spectroscopie IRTF et MEB-EDS, est corrélé à la présence de chlore et de gypse dans les couches picturales. Différents essais de dessalement des fragments par bains et utilisation de compresses ont été effectués. Des analyses de la teneur en sels solubles des fragments dessalés et des dosages dans les bains ont montré que les protocoles étudiés permettent de diminuer la quantité de chlore présent dans la couche picturale et ainsi de ralentir efficacement le noircissement.
Enquêter dans le noir : faire parler les armatures des crêtes de faîtage de Notre-Dame de Paris, vestiges de l’incendie du 15 avril 2019
Authors: Azéma Aurélia , Syvilay Delphine , L’Héritier Maxime 
Published: March 2024

L’incendie du 15 avril 2019 a provoqué la disparition de la toiture de la cathédrale Notre-Dame de Paris. Telles sont les apparences depuis le sol, mais, en prenant un peu de hauteur, la réalité est tout autre. Les éléments décoratifs qui la composaient se sont principalement transformés sous l’effet de l’incendie, y ont perdu leurs cohérences, leurs fonctions originelles dans l’édifice, se retrouvant tous rassemblés en un amas confus de matières noires. De longs mois de tri selon une méthodologie adaptée, construite sur le modèle des fouilles archéologiques, ont permis de dresser un bilan quantitatif, mais aussi une estimation de l’état de conservation de ces vestiges. Que les débris soient in fine réemployés ou bien qu’ils servent de témoins patrimoniaux, ces travaux facilitent le travail de la maîtrise d’œuvre et de la maîtrise d’ouvrage en charge de la reconstruction, mais aussi les recherches relatives à l’histoire de la construction et des restaurations de la cathédrale.Parmi les milliers de clous, les centaines de tiges boulonnées ou encore l’ensemble des armatures de la charpente, les squelettes en fer qui armaient la coque en plomb des éléments de crête de faîtage ont fait l’objet d’une recherche approfondie. Une étude archivistique menée en parallèle d’une approche typologique et matérielle a rendu possible la reconstitution de ce véritable puzzle géant et complexe, compte tenu du caractère méconnaissable de certaines pièces. Cette enquête a permis de comprendre les différentes phases d’interventions sur ces objets ainsi que leur évolution technique au fil des décennies, depuis leur création au xixe siècle par l’architecte Viollet-le-Duc jusqu’aux stratégies de restauration adoptées aux xxe et xxie siècles (réemploi, modification, remplacement).
New gravitational model and quantization formula of the gravitational constant
Authors: Kang Ning bo 
Published: March 2024

The existing theories of gravitation cannot solve the problem of the gravitational quantization, and the exact value of the Newtonian constant of gravitation G has not been determined. Therefore, the essence of gravity needs to be deeply explored. Here, we show that a new gravitational
model is proposed, which is of the viewpoint that the universe is a composition of elementary particles and gravitational lines, and the elementary particles are connected by gravitational lines, and the essence of gravity can be tension of the gravitational lines. Based on Newton's law of
gravitation, quantum mechanics, and simple harmonic wave equation, the dynamic model of gravitational driven photons is constructed: <mml:math display="inline"> <mml:mrow> <mml:mrow> <mml:mi>G</mml:mi> <mml:msubsup> <mml:mi>m</mml:mi> <mml:mi>g</mml:mi>
<mml:mn>2</mml:mn> </mml:msubsup> </mml:mrow> <mml:mi>/</mml:mi> <mml:mrow> <mml:msub> <mml:mi>l</mml:mi> <mml:mi>p</mml:mi> </mml:msub> </mml:mrow> <mml:mo>=</mml:mo> <mml:mo>Δ</mml:mo>
<mml:mi>n</mml:mi> <mml:mo>⋅</mml:mo> <mml:mrow> <mml:mi>h</mml:mi> <mml:mi>c</mml:mi> </mml:mrow> <mml:mi>/</mml:mi> <mml:mi>λ</mml:mi> </mml:mrow> </mml:math> . The quantization formula
of the gravitational constant is derived: <mml:math display="inline"> <mml:mrow> <mml:msub> <mml:mi>G</mml:mi> <mml:mi>q</mml:mi> </mml:msub> <mml:mo>=</mml:mo> <mml:mrow> <mml:mi>K</mml:mi> <mml:msup> <mml:mi>h</mml:mi>
<mml:mn>3</mml:mn> </mml:msup> </mml:mrow> <mml:mi>/</mml:mi> <mml:mrow> <mml:mn>2</mml:mn> <mml:mi>π</mml:mi> <mml:msup> <mml:mi>c</mml:mi> <mml:mn>2</mml:mn> </mml:msup> <mml:msubsup>
<mml:mi>m</mml:mi> <mml:mi>g</mml:mi> <mml:mn>4</mml:mn> </mml:msubsup> </mml:mrow> </mml:mrow> </mml:math> . The calculated average is G = 6.678 804 09 × 10−11 m3 kg−1 s−2.
Compared with the recommendations value of the CODATA in 2018, the deviation obtained is 0.067%. The quantum formula of gravity is derived: <mml:math display="inline"> <mml:mrow> <mml:msub> <mml:mi>f</mml:mi> <mml:mi>G</mml:mi> </mml:msub> <mml:mo>=</mml:mo>
<mml:mrow> <mml:mi>K</mml:mi> <mml:msup> <mml:mi>h</mml:mi> <mml:mn>3</mml:mn> </mml:msup> </mml:mrow> <mml:mi>/</mml:mi> <mml:mrow> <mml:mn>2</mml:mn> <mml:mi>π</mml:mi> <mml:msup>
<mml:mi>c</mml:mi> <mml:mn>2</mml:mn> </mml:msup> <mml:msubsup> <mml:mi>m</mml:mi> <mml:mi>g</mml:mi> <mml:mn>2</mml:mn> </mml:msubsup> </mml:mrow> </mml:mrow> </mml:math> . The gravitational model
proposed in this paper solves the problem of gravitation quantization, deduces the formula of the gravitational constant and gravitational quantum, and provides a new theoretical method for deeply revealing the essence of gravity.
Uncommon Posterior Disc Displacement of Temporomandibular Joint - A Case Report
Authors: AlKandari Ahmad Gh. , Karkar Khalid Tarek 
Published: March 2024

Abstract

Rationale:
Posterior disc displacement (PDD) is an uncommon condition in which disc tissue is located between the posterior surface of the condyle and post-glenoid tubercle. The etiopathogenesis of this condition is idiopathic. There are different predisposing factors in the literature which are consistent with the presented case such as lack of anterior prominence of the disc, thinning of the posterior zone of the disc and perforation of the disc.

Patient Concerns:
We report an uncommon temporomandibular joint (TMJ) arthropathy case of a 33-year-old female patient, who presented with long-standing TMJ pain associated with limited mouth opening.

Diagnosis:
The patient was diagnosed with non-reducible PDD of TMJ bilaterally.

Treatment:
Open surgery of TMJ (Discopexy) was the choice of treatment to release and mobilise discs.

Outcomes:
A noticeable increase in mouth opening without pain in TMJ area was achieved immediately after surgery and remained stable during periodic follow-ups.

Take-away Lessons:
The importance of magnetic resonance imaging as a diagnostic tool for arthropathy, to determine the proper management is essential. Moreover, the root of the helix inter tragus notch incision presents an advantage of open surgery of TMJ which results in immediate outcome with limited complications.
An Anaplastic Lymphoma Kinase-positive Inflammatory Myofibroblastic Tumor with Rapidly Acquired Resistance to First-line Anaplastic Lymphoma Kinase Inhibitor: A Case and Literature Review
Authors: Wu Shu-Cheng , Chen Hsing-Wu 
Published: March 2024

Abstract
Inflammatory myofibroblastic tumors (IMTs) are soft-tissue neoplasms with rare metastatic potential. Approximately half of IMTs are positive for an anaplastic lymphoma kinase (ALK) gene rearrangement which causes aberrant expression. Early phase clinical trials have demonstrated the efficacy of ALK inhibitors in the treatment of IMTs. However, there is no definite conclusion on which ALK inhibitor performs best, and data regarding subsequent therapy after first-line ALK inhibitor failure are scarce. Here, we report a case of ALK+ metastatic IMT that demonstrated a dramatic response to first-line alectinib but resulted in rapidly acquired resistance. Repeated biopsy and next-generation sequencing (NGS) showed ALK:c.3604G>A; p.(Gly1202Arg), which is a common mechanism of drug resistance in ALK fusion-positive non-small cell lung cancer. We also report subsequent treatment choices and responses in this patient and perform a literature review regarding similar cases as this rare tumor.
David Slays Goliath: Exceptional Efficacy of Oral Vinorelbine in Conquering Metastatic Finger Angiosarcoma
Authors: Hsu Te-Lin , Chen San-Chi 
Published: March 2024

Abstract
Angiosarcoma (AS) is a rare and aggressive disease originating from blood or lymphatic vessel endothelium, representing <1% of soft-tissue sarcomas. The prognosis is generally poor, with a 5-year survival rate of only 30%–50%. The recurrence rate is high, and metastasis occurs in about half of the cases. The National Comprehensive Cancer Network guidelines recommend anthracycline-based, gemcitabine-based, and paclitaxel regimens as preferred first-line treatments for metastatic AS. Vinorelbine, a vinca alkaloid, is listed as supportive care in AS for patients unsuitable for intensive chemotherapy or who are heavily treated. Although the efficacy of vinorelbine is modest, some studies suggest its synergistic effect with immunotherapy. In our case report, a patient with metastatic AS received frontline paclitaxel followed by pembrolizumab, but this treatment failed. However, a complete response (CR) was achieved after oral vinorelbine. Remarkably, the patient remains in CR for 4.5 years after discontinuing vinorelbine.
Epidermal Growth Factor Receptor Exon 19 Deletion Subtypes Do Not Influence Survival Outcomes Following First-line Epidermal Growth Factor Receptor-tyrosine Kinase Inhibitors in Advanced Nonsmall Cell Lung Cancer Patients
Authors: Tang Yan-Jei , Chang John Wen-Cheng , Huang Chen-Yang , Fang Yueh-Fu , Chang Ching-Fu , Yang Cheng-Ta , Kuo Chih-Hsi Scott , Hsu Ping-Chih , Wu Chiao-En 
Published: March 2024

Abstract

Background:
Several deletion and insertion subtypes occur in exon 19 of the epidermal growth factor receptor (EGFR) gene, collectively called exon 19 deletions (del19), and are one of the common EGFR mutations in nonsmall cell lung cancer (NSCLC). Previous studies have shown that del19 subtypes might influence the response to tyrosine kinase inhibitors (TKIs), but their findings have been inconsistent. Therefore, this study aimed to evaluate the impact of del19 subtypes in an Asian population and provide additional evidence on this issue.

Materials and Methods:
NSCLC patients treated at Chang Gung Medical Hospitals between 2011 and 2018 were retrospectively reviewed. Their clinicopathological characteristics, clinical tumor response, progression-free survival (PFS), and overall survival (OS) were collected. PFS was evaluated among different del19 subtypes and EGFR-TKIs.

Results:
This study included 164 patients with NSCLC carrying an EGFR del19 mutation who had detailed information about their del19 subtype and were treated with frontline EGFR-TKIs (39 with afatinib and 125 with gefitinib/erlotinib). In this cohort, del19 subtypes did not influence PFS and OS based on different classifications, including start codon of deletion, the number of deleted nucleotides, or pure deletion versus mixed deletion/insertion/substitution. In addition, afatinib generally showed better PFS than gefitinib/erlotinib, particularly and significantly for patients with the p. E746_A750 mutation, a common 15 nucleotide deletion, or a pure deletion without insertion/substitution.

Conclusion:
In this study, del19 subtypes did not influence PFS and OS with EGFR-TKIs. Afatinib showed better activity than first-generation TKIs and should be preferred for patients with del19 mutations.
The Clinical and Microbiological Characteristics of Fungal Keratitis in COVID-19 Period
Authors: Sankolli Nikhita Anil , Biradar Sunil Gurupadappa , Shahapur Praveen , Israel Mervin Jonathan 
Published: March 2024

Abstract

Context:
In India, the incidence of fungal keratitis ranges from 44% to 47%, due to its tropical environment and huge at-risk agricultural population. The emergence of COVID-19 has influenced the medical management of fungal keratitis.

Aim:
The aim of this study was to assess the clinical and microbiological characteristics of fungal corneal ulcers during COVID-19 period.

Settings and Design:
This was a cross-sectional study of 1-year duration.

Subjects and Methods:
Fifty-two KOH mount-positive and fungal culture-positive patients were included in the study. Ophthalmic examination, including best-corrected visual acuity, slit-lamp examination, fluorescent staining was done, Anterior segment optical coherence tomography (ASOCT). Corneal scraping was sent for 10% KOH mount and fungal cultures with Sabouraud’s dextrose agar for growth.

Statistical Analysis Used:
The Statistical Package for the Social Sciences (Version 20) was used for statistical analysis.

Results:
Fifty-two KOH mount and fungal culture-positive patients were included, with a mean age of 50.88 years. 53.8% were farmers. 55.6% had a history of trauma with organic matter. The common signs noted were an irregular, dry looking, central corneal ulcer measuring 2-5mm extending 20-50% deep, mid stromal infiltration, satellite lesions and surrounding stromal oedema. Eleven presented with perforation. The best-corrected visual acuity was hand movements (32.7%). The KOH mount positive among the screened patients was 46.7%, of which 52 were culture positive. Aspergillus fumigatus (61.5%) was the predominant cause of mycotic keratitis.

Conclusion:
Mycotic keratitis was mostly caused by filamentous fungus and was most frequently observed among farmers. COVID-19 has increased the cases of perforated corneal ulcers, and ASOCT was the noninvasive, feasible tool to assess the cornea.
Diabetic Distress in Adults with Type II Diabetic Mellitus: A Community Based Study
Authors: Todalabagi Pooja , Manjula R. , Anjali  , Yadavannavar Mallikarjun 
Published: March 2024

Abstract

Background:
Diabetes is a challenging disease that is considered to be hard to live with as it encompasses a lot of restrictive instructions. Diabetic distress (DD) refers to an emotional state where people experience feelings such as stress, guilt, or denial that arise from the living with diabetes and the burden of self-management. This study was done to assess the DD in rural and urban area of north Karnataka.

Methodology:
A nonrandomized educational interventional study (before and after comparative study without control) with 129 urban and 63 rural study participants was conducted in urban and rural field practice area of S. Nijalingappa Medical College, Bagalkot. Data were collected using pretested and predesigned pro forma which included sociodemographic details and DD score scale. Health education intervention was followed by postintervention data collection.

Results:
Most of the participants were in their old age. Male predominance was seen. Most of the participants belonged to Hindu religion (57% in rural and 69% in urban) and illiterate (46.5% in rural and 41.3% in urban). There was a significant reduction in DD (mean difference = 0.7, standard deviation = 0.7), when the study participants were given educational intervention.

Conclusion:
To combat the stress associated with diabetes, it is important to educate the patient to adapt with change in their lifestyle following the diagnosis of diabetes.
Health Status of Cotton-ginning Workers in Central India: A Cross-sectional Study
Authors: Rathod Sangharsh S. , Kasdekar Pankaj M. , Bramhankar Tanuja R. , Dhakate Manish Arun , Khakse Gautam Marotrao 
Published: March 2024

Abstract

Introduction:
Cotton ginning is an important industry in Central India, employing a significant number of workers. The cotton-ginning industry is associated with various occupational health hazards, including exposure to cotton dust, which can lead to respiratory problems such as byssinosis. In addition, cotton-ginning workers are also exposed to workplace stress, which can have negative impacts on their physical and mental health.

Aims:
The aim of this cross-sectional study is to assess the health status of cotton-ginning workers in Central India.

Methodology:
A total of 285 cotton-ginning workers from various factories in Central India were recruited for this study. Data on sociodemographic characteristics, occupational characteristics, presence of byssinosis, and workplace stress were collected through a structured questionnaire. The Roach and Schilling criteria for byssinosis were used to assess the presence of this byssinosis. Workplace stress was assessed using the Workplace Stress Scale, which is a validated tool for assessing stress in occupational settings. Data were analyzed using R software 4.2.2.

Results:
The majority of cotton-ginning workers were female (71.2%) and had a primary level of education (51.3%). Most workers (77.54%) had been employed in the industry for 1–5 years, and the majority of workers (55.8%) worked as helpers. Only 4.21% of workers reported having byssinosis. The majority of workers (63.51%) reported lower levels of workplace stress, while a small proportion (3.16%) reported severe levels of workplace stress.

Conclusion:
The results of this study suggest that the health status of cotton-ginning workers in Central India is relatively good. However, there is a need to implement appropriate occupational health and safety measures which are inclusive of all workers, not just machine operators.
Impact of Online Teaching on Dental Students in COVID Era
Authors: Gawande Madhuri , Pakhale Aayushi , Hande Alka , Patil Swati , Sonone Archana , Khan Samiha 
Published: March 2024

Abstract

Aim and Objectives:
Education is requisite for humankind. In the COVID pandemic, as humanity was endangered, education was devalued. Neglecting education for a long period would have caused a great loss of students. Hence, the online teaching approach was initiated to maintain continuity in education. In the present study, the impact of online teaching was studied on dental students during the COVID pandemic.

Materials and Methods:
Students of Bachelor of Dental Surgery of all four academic years were evaluated by their annual attendance and their summative examination results (in percentage) during online teaching.

Conclusion:
We concluded that the attendance and results of students could be correlated during online teaching. Online teaching was an effective substitute during the COVID pandemic.
Impact of Self-reported Leisure Internet Usage on Social Interactions
Authors: Doshi Dolar , Sukhabogi Jagadeeswara Rao , Kumari V.B.P. Surya , Reddy Y. Pallavi 
Published: March 2024

Abstract

Aim:
This study aimed to determine whether leisure Internet usage affects social interactions among undergraduate dental students.

Methods:
All undergraduate dental students of Government Dental College and Hospital, Hyderabad, were included in the study. Leisure Internet usage was assessed using a fifteen-item Internet Disorder scale (IDS-15). Short form of the Social Interaction Anxiety (SIAS-6) and Social Phobia Scale (SPS-6) evaluated Social interaction anxiety and social phobia. The frequency distribution of responses IDS-15, SIAS-6, and SPS-6 was calculated based on gender and year of study. The mean response score was computed and compared based on demographic variables.

Results:
The total mean IDS-15 score for the study population was 39.09 ± 8.35. Average time spent on Internet per day was a significant variable for IDS-15 and its factors, with the highest mean score observed for those using Internet for more than 5 h/day. Although half of the population (165; 50%) revealed Internet addiction based on the IDS-15 scale, the majority of the population had low levels of social interaction anxiety (60.3%) and social phobia (69.39%). A positive and significant relation was noted between the total IDS-15 scale with both the social scales.

Conclusion:
Based on the analysis of this study, it was seen that 50% of the population had self-reported leisure Internet addiction. The amount of time spent emerged as a significant factor and a positive relation between the Internet usage and anxiety and phobia in social situations was also noted in this study.
Incidence of ABO Blood Groups in Patients with Oral Cancer, Premalignant Conditions, and Lesions: A Prospective Observational Study
Authors: Pokala Archana , Valishetty Anuhya , Devulapally Revath Vyas , Tejasvi ML Avinash , Nadendla Lakshmi Kavitha , Mekala Mounika Reddy 
Published: March 2024

Abstract

Aim of the Study:
The aim was to assess the incidence and to correlate ABO blood groups in patients with oral cancer, premalignant conditions, and lesions.

Materials and Methods:
It is a prospective observational study. ABO blood grouping was done on 120 cases, of which 60 were with oral cancer, 20 with oral submucous fibrosis, 20 with leukoplakia, and 20 with lichen planus. About 120 healthy subjects were selected after randomization. The obtained data were subjected to statistical analysis.

Results:
Out of 120 precancerous and cancerous cases, 26 had blood group A (21.6%), 46 had blood group B (38.3%), 5 had blood group AB (4.2%), and 43 had blood group O (35.83%). Among the controls, out of 120 subjects, 24 had blood group A (20%), 40 had blood group B (33.33%), 5 had blood group AB (4.2%), and 51 had blood group O (42.5%). The strength of association between was assessed using the odd’s ratio and found that people with blood group B had 1.24 times higher risk of developing oral precancerous and cancerous lesions compared to people of other blood groups. The relative risk was 1.11 for people with blood group A and 1 for those with blood group AB. The relative risk for people with blood group O was 0.75.

Conclusions:
In the present study, it was found that people with blood group B are at a greater risk of developing oral malignancies, followed by those with blood group A, AB, and O.
Pharmacognostical (Ingredient Analysis) and Pharmaceutical Evaluation of Yashtimadhu Taila (Glycyrrhiza glabra Linn.)
Authors: Kumbhani Rajeshree Bhagvanjibhai , Dudhamal T. S. , Shukla V. J. , Harisha C. R. 
Published: March 2024

Abstract

Context:
In Ayurveda, Yashtimadhu is being used as one of the healing drugs in the management of different kinds of wounds. The preparations made from Yashtimadhu such as Churna, Ghrita, Taila, and Malahar are being practiced in wound care unit to treat different kinds of wounds as local application. Multiple treatment modalities are mentioned in Sushruta Samhita for the management of various types of Vrana.

Aim and Objective:
This study was to standardize the finished product Yashtimadhu Taila to confirm its identity, quality, and purity. Yashtimadhu Taila is standardized using different parameters like pharmacognostical study including organoleptic characters such as color, odor, and taste.

Subjects and Methods:

Yashtimadhu Taila is prepared as per Sneh Kalpana mentioned in Sharangdhara Samhita. The pharmacognostical study includes organoleptic characters such as color, odor, and taste. The pharmaceutical study of Yashtimadhu Taila includes specific gravity, acid value, saponification, iodine value, and refractive index by the following standard procedures as per the Ayurvedic Pharmacopoeia of India, and chromatographic examination includes high-performance thin-layer chromatography (HPTLC) study.

Results:
All the physicochemical parameters show acid value (0.4883), saponification (178.7), iodine value (82.91), and refractive index (1.4820). HPTLC profile of the methanolic extract of the drug showed 14 spots at 254 nm and 8 spots at 366 nm.

Conclusions:
This study will be helpful to establish the safety profile, efficacy, and acceptance of classical parameters for further research studies.