bluuebunny/crossref_metadata_2025_split huggingface dataset:
ERAP1 and ERAP2 gene variants as potential clinical biomarkers of anti-interleukin-17A response in psoriasis vulgaris
Authors: Kronborg Lasse , Hansen Emma Oxlund , Bertelsen Trine , Rittig Anne Hald , Emmanuel Thomas , Jørgensen Sofie , Hjuler Kasper Fjellhaugen , Iversen Lars , Johansen Claus 
Published: April 2024

Abstract

Background
Interleukin (IL)-17A is a proinflammatory cytokine that plays an essential role in the development of psoriasis. Although treatment with anti-IL-17A monoclonal antibodies has demonstrated high efficacy in patients with psoriasis, not all patients respond equally well, highlighting the need for biomarkers to predict treatment response. Specific single-nucleotide polymorphisms (SNPs) in the genes encoding endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) have been associated with psoriasis and other immune-mediated diseases.

Objectives
To investigate the association between the ERAP1 and ERAP2 genotypes and response to secukinumab treatment in patients with psoriasis.

Methods
In total, 75 patients with plaque psoriasis were included. All patients were genotyped for the ERAP1 rs27524, rs27044, rs30187, rs2287987 and rs26653 SNPs, the ERAP2 rs2248374 SNP, and the status of the human leucocyte antigen HLA-C*06:02 gene.

Results
Our results demonstrated that individuals with specific ERAP1 and ERAP2 genotypes had a considerably lower response rate to secukinumab treatment. Patients with the ERAP2 rs2248374 GG genotype had a more than sixfold increased risk of treatment failure compared with patients with the rs2248374 AG or AA genotypes. Stratifying for HLA-C*06:02 status, the ERAP2 GG genotype pointed towards an increased risk of treatment failure among HLA-C*06:02-positive patients, although this was not statistically significant.

Conclusions
Taken together, this unique study breaks new ground by identifying distinct ERAP1 and ERAP2 gene variants that may serve as potential biomarkers for predicting the treatment response to secukinumab in patients with psoriasis. Notably, our data extend existing knowledge by linking specific ERAP1 and ERAP2 gene variants to treatment outcome.
Estimation of the rate constants for the radical addition of a trifluoromethyl radical to aryl-substituted vinyl triflates
Authors: Kawamoto Takuji , Hisayuki Mai , Kamimura Akio 
Published: April 2024

Abstract
The rate constants for the radical addition of a trifluoromethyl radical to aryl-substituted vinyl triflates have been determined by applying competition kinetics at a single concentration point. The rate constants range from 4.1× 106 to 5.6× 106 M−1 s−1 and depend on the electronic properties of the benzene rings on the aryl-substituted vinyl triflates.
The elephant’s Achilles’ heel: a case report of acute obstruction of frozen elephant trunk after proximal aortic dissection repair
Authors: Nienaber Stephan , Yuan Xun , Price Susanna , Rosendahl Ulrich , Nienaber Christoph A 
Published: April 2024

Abstract

Background
The frozen elephant trunk (FET) technique as a hybrid combining surgical and endovascular repair is an emerging concept to treat complex aortic dissection. Early experience showed technical feasibility and promising clinical outcomes. However, unsuspected complications still arise.

Case summary
A 25-year-old male presented to the emergency department with a 2-day history of chest pain. After exclusion of acute coronary syndrome, a computed tomography angiography (CTA) revealed Type A (DeBakey Type I) aortic dissection. The patient underwent median stenotomy for complete replacement of the ascending aorta, the aortic arch, and FET. Early after rewarming, the patient became unstable due to severe left ventricular dysfunction. Soon veno-arterial extracorporal membrane oxygenation (VA-ECMO) was required for circulatory support. The cause of deterioration remained unclear until repeated CTA showed acute obstruction of the FET. Invasive exploration confirmed a trans-FET gradient of 100 mmHg, successfully managed by repeated balloon inflation with resolution of both obstruction and gradient. The patient recovered completely without any sequela.

Discussion
While the mechanism of acute obstruction after FET remains subject to speculation, the rescue intervention of ballooning the obliteration on VA-ECMO was life-saving. Intraoperative ultrasound and videoscopic inspection may be instrumental before chest closure to avoid such critical events.
A case report of concurrent management of acute myocardial infarction complicated by left ventricular thrombus and ischaemic stroke
Authors: Kodama Yuka , Matsumoto Kenji , Kubota Hisashi , Furuya Onichi , Kawase Yoshio 
Published: April 2024

Abstract

Background
Left ventricular thrombus (LVT) formation is a serious complication of acute myocardial infarction (AMI) requiring complicated management strategies and collaboration among cardiologists, cardiovascular surgeons, and neurosurgeons.

Case summary
We present the case of an 83-year-old female patient with AMI. Emergency coronary angiography revealed subtotal occlusion of the proximal left anterior descending artery, and the patient was successfully treated with a drug-eluting stent. The following day, she suddenly developed loss of consciousness, global aphasia, and right hemiplegia. Brain magnetic resonance imaging revealed acute ischaemic cerebral infarction caused by multiple mobile LVT, as demonstrated by echocardiography. After a heart–brain team discussion, we decided to perform percutaneous mechanical thrombectomy. Successful recanalization was achieved with mechanical thrombectomy 2 h after presentation, which resulted in significant neurological recovery. Immediately after the thrombectomy, she was transferred to a cardiovascular surgery centre for surgical removal of multiple LV apical thrombi. Two weeks after the operation, the patient was discharged with the recovery of LV systolic function.

Discussion
Although AMI complicated by acute stroke caused by LVT remains a clinical challenge, a multidisciplinary approach is critically important for optimal care. Based on an urgent team discussion, we decided to perform endovascular thrombectomy for ischaemic stroke, followed by surgical removal of the LVT, requiring patient transportation to the cardiovascular surgery centre. Given that the heart and brain team-based approach remains confined to large, specialized centres, it might be beneficial to establish a community-based integrated heart–brain team that can address the growing needs of complex patients.
A new data infrastructure for family research and demographic analysis: the German Family Demography Panel Study (FReDA)
Authors: Hank Karsten , Gummer Tobias , Bujard Martin , Neyer Franz J , Pollak Reinhard , Spieß C Katharina , Wolf Christof , Christmann Pablo , Kunz Tanja , Lück Detlev , Naderi Robert , Nutz Theresa , Schmid Lisa , Thönnissen Carolin 
Published: April 2024

Abstract
This data brief introduces the German Family Demography Panel Study (FReDA; https://www.freda-panel.de/), a longitudinal, multi-actor database for family research. Major substantive fields addressed in the questionnaire include fertility-related attitudes and behaviours, reproductive health, work-family conflict, couples’ division of labour, gender roles, intimate relationships, separation and divorce, parenting and intergenerational relations, and well-being. FReDA is based on two initially independent samples: the newly drawn FReDA-GGS sample (n_recruitment = 37,777 respondents, aged 18–49 years), constituting the German contribution to the Generations and Gender Surveys (GGS-II), and the FReDA-pairfam sample (n = 6,216 respondents who originally participated in the German Family Panel [pairfam]). Both samples are fully integrated, using one survey instrument consisting of the harmonized GGS-II and pairfam questionnaires. Mainly web-based interviews, complemented by paper-based interviews, are conducted biannually, with one wave being split across two subwaves. We provide a short description of FReDA’s forerunners—the GGS and pairfam—and give an overview of FReDA’s design and content, its baseline wave (collected in 2021) and data releases, as well as a brief outlook on FReDA’s road ahead.
Online customized strategy for manufacturers to counter showrooming behavior in a dual-channel supply chain
Authors: Lei Qian , He Juan 
Published: April 2024

Abstract
Accepted by: M. Zied Babai
Showrooming refers to a behavior of consumer transferring from offline stores to online purchasing. Consumers’ showrooming behavior would affect not only the offline stores but also manufacturers in the long run. This study aims at putting forward an online customized strategy offered by a manufacturer to defeat the negative of showrooming in the context of a dual-channel supply chain where a manufacturer sells products online to consumers via a direct channel and wholesales products to an offline retailer, then the retailer sells products via an offline channel. Based on game theory and backward induction, optimal pricing decisions for the manufacturer and the retailer are established. It shows that consumers’ showrooming behavior decreases the selling prices and increases sales volumes in both the online direct channel and the offline channel. As further revealed, showrooming behavior would hurt the retailer under certain conditions and always damage the manufacturer. To mitigate the negative effects of showrooming, an online customized strategy is developed for the manufacturer. That is, the manufacturer would provide standard and customized products for online channel, allowing offline channel to sell only standard products. According to the results, online customized strategy would always damage the interests of the retailer, while customized strategy increases the profit of the manufacturer and increases the social welfare of the supply chain under certain circumstances.
Aberrant microbiomes are associated with increased antibiotic resistance gene load in hybrid mice
Authors: Jarquín-Díaz Víctor Hugo , Ferreira Susana Carolina Martins , Balard Alice , Ďureje Ľudovít , Macholán Milos , Piálek Jaroslav , Bengtsson-Palme Johan , Kramer-Schadt Stephanie , Forslund-Startceva Sofia Kirke , Heitlinger Emanuel 
Published: April 2024

Abstract
Antibiotic resistance is a priority public health problem resulting from eco-evolutionary dynamics within microbial communities and their interaction at a mammalian host interface or geographical scale. The links between mammalian host genetics, bacterial gut community, and antimicrobial resistance gene (ARG) content must be better understood in natural populations inhabiting heterogeneous environments. Hybridization, the interbreeding of genetically divergent populations, influences different components of the gut microbial communities. However, its impact on bacterial traits such as antibiotic resistance is unknown. Here, we present that hybridization might shape bacterial communities and ARG occurrence. We used amplicon sequencing to study the gut microbiome and to predict ARG composition in natural populations of house mice (Mus musculus). We compared gastrointestinal bacterial and ARG diversity, composition, and abundance across a gradient of pure and hybrid genotypes in the European House Mouse Hybrid Zone. We observed an increased overall predicted richness of ARG in hybrid mice. We found bacteria–ARG interactions by their co-abundance and detected phenotypes of extreme abundances in hybrid mice at the level of specific bacterial taxa and ARGs, mainly multidrug resistance genes. Our work suggests that mammalian host genetic variation impacts the gut microbiome and chromosomal ARGs. However, it raises further questions on how the mammalian host genetics impact ARGs via microbiome dynamics or environmental covariates.
Lactic acid bacteria modulate the CncC pathway to enhance resistance to β-cypermethrin in the oriental fruit fly
Authors: Zeng Tian , Fu Qianyan , Luo Fangyi , Dai Jian , Fu Rong , Qi Yixiang , Deng Xiaojuan , Lu Yongyue , Xu Yijuan 
Published: April 2024

Abstract
The gut microbiota of insects has been shown to regulate host detoxification enzymes. However, the potential regulatory mechanisms involved remain unknown. Here, we report that gut bacteria increase insecticide resistance by activating the cap “n” collar isoform-C (CncC) pathway through enzymatically generated reactive oxygen species (ROS) in Bactrocera dorsalis. We demonstrated that Enterococcus casseliflavus and Lactococcus lactis, two lactic acid-producing bacteria, increase the resistance of B. dorsalis to β-cypermethrin by regulating cytochrome P450 (P450) enzymes and α-glutathione S-transferase (GST) activities. These gut symbionts also induced the expression of CncC and muscle aponeurosis fibromatosis. BdCncC knockdown led to a decrease in resistance caused by gut bacteria. Ingestion of the ROS scavenger vitamin C in resistant strain affected the expression of BdCncC/BdKeap1/BdMafK, resulting in reduced P450 and GST activity. Furthermore, feeding with E. casseliflavus or L. lactis showed that BdNOX5 increased ROS production, and BdNOX5 knockdown affected the expression of the BdCncC/BdMafK pathway and detoxification genes. Moreover, lactic acid feeding activated the ROS-associated regulation of P450 and GST activity. Collectively, our findings indicate that symbiotic gut bacteria modulate intestinal detoxification pathways by affecting physiological biochemistry, thus providing new insights into the involvement of insect gut microbes in the development of insecticide resistance.
How do grazing beef and dairy cattle respond to virtual fences? A review
Authors: Wilms Lisa , Komainda Martin , Hamidi Dina , Riesch Friederike , Horn Juliane , Isselstein Johannes 
Published: April 2024

Abstract
Virtual fencing (VF) is a modern fencing technology that requires the animal to wear a device (e.g., a collar) that emits acoustic signals to replace the visual cue of traditional physical fences (PF) and, if necessary, mild electric signals. The use of devices that provide electric signals leads to concerns regarding the welfare of virtually fenced animals. The objective of this review is to give an overview of the current state of VF research into the welfare and learning behavior of cattle. Therefore, a systematic literature search was conducted using two online databases and reference lists of relevant articles. Studies included were peer-reviewed and written in English, used beef or dairy cattle, and tested neck-mounted VF devices. Further inclusion criteria were a combination of audio and electrical signals and a setup as a pasture trial, which implied that animals grazed in groups on grassland for 4 h minimum while at least one fence side was virtually fenced. The eligible studies (n = 13) were assigned to one or two of the following categories: animal welfare (n studies = 8) or learning behavior (n studies = 9). As data availability for conducting a meta-analysis was not sufficient, a comparison of the means of welfare indicators (daily weight gain, daily lying time, steps per hour, daily number of lying bouts, and fecal cortisol metabolites [FCM]) for virtually and physically fenced animals was done instead. In an additional qualitative approach, the results from the welfare-related studies were assembled and discussed. For the learning behavior, the number of acoustic and electric signals and their ratio were used in a linear regression model with duration in days as a numeric predictor to assess the learning trends over time. There were no significant differences between VF and PF for most welfare indicators (except FCM with lower values for VF; P = 0.0165). The duration in days did not have a significant effect on the number of acoustic and electric signals. However, a significant effect of trial duration on the ratio of electric-to-acoustic signals (P = 0.0014) could be detected, resulting in a decreasing trend of the ratio over time, which suggests successful learning. Overall, we conclude that the VF research done so far is promising but is not yet sufficient to ensure that the technology could not have impacts on the welfare of certain cattle types. More research is necessary to investigate especially possible long-term effects of VF.
Diabetes increases risk of lumbar spinal fusion complications: association with altered structure of newly formed bone at the fusion site
Authors: Wilson Claire , Czernik Piotr J , Elgafy Hossein , Khuder Sadik , Serdahely Kevin , Rowland Andrea , Lecka-Czernik Beata 
Published: April 2024

Abstract
Diabetes predisposes to spine degenerative diseases often requiring surgical intervention. However, the statistics on the prevalence of spinal fusion success and clinical indications leading to the revision surgery in diabetes are conflicting. The purpose of the presented retrospective observational study was to determine the link between diabetes and lumbar spinal fusion complications using a database of patients (n = 552, 45% male, age 54 ± 13.7 years) residing in the same community and receiving care at the same health care facility. Outcome measures included clinical indications and calculated risk ratio (RR) for revision surgery in diabetes. Paravertebral tissue recovered from a non-union site of diabetic and nondiabetic patients was analyzed for microstructure of newly formed bone. Diabetes increased the RR for revision surgery due to non-union complications (2.80; 95% CI, 1.12–7.02) and degenerative processes in adjacent spine segments (2.26; 95% CI, 1.45–3.53). In diabetes, a risk of revision surgery exceeded the RR for primary spinal fusion surgery by 44% (2.36 [95% CI, 1.58–3.52] vs 1.64 [95% CI, 1.16–2.31]), which was already 2-fold higher than diabetes prevalence in the studied community. Micro-CT of bony fragments found in the paravertebral tissue harvested during revision surgery revealed structural differences suggesting that newly formed bone in diabetic patients may be of compromised quality, as compared with that in nondiabetic patients. In conclusion, diabetes significantly increases the risk of unsuccessful lumbar spine fusion outcome requiring revision surgery. Diabetes predisposes to the degeneration of adjacent spine segments and pseudoarthrosis at the fusion sites, and affects the structure of newly formed bone needed to stabilize fusion.
The OECD’s new discourse of curriculum reform: student agency, competency, colonization, and translation
Authors: Lee Sangeun 
Published: April 2024

Abstract
The Organization of Economic Co-operation and Development’s (OECD) global governance of education has been gradually increasing. Its field of interest is currently expanding from educational evaluation through the Program for International Student Assessment (PISA) to curriculum reform through the Education 2030 project. Here, it is interesting to note that the nature of the terms the OECD has been creating reveals a ‘humanistic turn’. This shows up well in the frequent occurrence of terms such as ‘well-being’, ‘attitudes and values’, ‘inclusiveness’, ‘responsibility’, and ‘sustainability’ in the ongoing Education 2030 project. Perhaps this new humanistic discourse increases the likelihood of the smooth adoption of the OECD’s proposed curriculum redesign in more countries. If the OECD’s new discourse captures and transforms contemporary people’s ways of thought and practice about education, then this is related to the problem of colonialism in our era. It is also worth noting that language plays a vital role in colonization. In particular, the need for translation between different languages serves as a useful means for colonization. Conversely, it is also seen as having a potential decolonizing power. In this context, I would like to examine the new language the OECD has adopted, specifically regarding student experience and the nature of knowing. Next, I shall attempt to criticize the underlying educational assumptions in the OECD’s pronouncements. Following this, I shall explore how the OECD’s new discourse has been translated in South Korea, taking this as an example of wider experience in the East Asian context and possibly elsewhere. Finally, I shall conclude by considering the direction of curriculum decolonization in terms of translation.
Ubuntu philosophy for ecological education and environmental policy formulation
Authors: Kyei-Nuamah David , Peng Zhengmei 
Published: April 2024

Abstract
A world faced with global climate change needs actionable ways to curb its effects. We suggest that Ubuntu philosophy is a way to achieve peaceful coexistence between humans and the ecosystem. From an African perspective, we use Ubuntu philosophy’s concepts to understand how humans can create environmental policies and environmental education pedagogy. We use historical ecology and document review to explore the connections between humans, ecology, and Ubuntu philosophy. An understanding of how philosophy and ecology relate is proposed to fill the gap in the cosmological premise between the African person and ecology. The study first sets out a relational model of humans and the ecosystem, then applies the ecology of education to environmental policy formulation. The research demonstrates that humanness with humaneness and collectivism, afro-eco-communitarianism, Ubuntu consensus politics, and Ubuntugogy are concepts underlying how the essence of Ubuntu philosophy can inform an ecofriendly society. The ethno-philo-cological underpinnings help conceptualize these concepts of community. Finally, the study’s conclusion shows how the concepts of Ubuntu philosophy suggest ways to improve environmental education and policy formulation. Climate concerns can be resolved by handing responsibility to the community.
Current status of testing intervals for antiphospholipid syndrome testing: a 13-year retrospective national data analysis in South Korea
Authors: Koo Se-eun , Hong Jinyoung , Park Kuenyoul , Jang Seongsoo 
Published: April 2024

Abstract

Objective
To assess the appropriateness of laboratory testing intervals and antiphospholipid syndrome (APS) incidence.

Methods
Between January 2010 and August 2022, insurance claims data of patients with disease codes for other thrombophilia (D68.6) and APS (V253) were retrieved in South Korea. Patients who received antiphospholipid antibody tests more than twice were classified as having suspected APS. The interval between the first 2 antiphospholipid antibody tests was evaluated in the patients with suspected APS. Patients with suspected APS who received anticoagulants for &gt;180 days were classified as having APS.

Results
Overall, 8656 patients were classified as having suspected APS. The testing interval for the first 2 tests in patients with suspected APS was &lt;6 and &lt;12 weeks in 11.1% and 20.6% of cases, respectively, in 2010, gradually increasing to 21.0% and 35.4%, respectively, in 2021. Subsequently, 4344 patients were classified as having APS, with 65.0% being female. Only 330 patients were diagnosed with APS in 2021, down from 436 in 2020.

Conclusion
This study showed a gradual increase in patients receiving antiphospholipid antibody testing with an inappropriate short-term interval, underscoring the need for laboratory stewardship to ensure an appropriate interval for APS testing.