bluuebunny/crossref_metadata_2025_split huggingface dataset:
Day‐To‐Day Variability of the Neutral Wind Dynamo Observed by ICON: First Results From Conjugate Observations
Authors: Harding Brian J. , Immel Thomas J. , Mende Stephen B. , Wu Yen‐Jung J. , Maute Astrid , England Scott L. , Heelis Roderick A. , Forbes Jeffrey M. , Englert Christoph R. , Marr Kenneth D. , Harlander John M. , Makela Jonathan J. , Frey Sabine 
Published: March 2024

AbstractFirst results are presented from the conjugate maneuvers performed by NASA's Ionospheric Connection Explorer (ICON) spacecraft. During each several‐minute maneuver, ICON crosses the magnetic equator, measuring the plasma drift at the ∼600‐km apex of a magnetic field line and the neutral wind profiles (∼90–300 km altitude) along both ends of that field line. The analysis utilizes 149 pairs of maneuvers separated by ∼24 hr but at nearly the same location and local time. Principal component regression reveals that 39 ± 7% and 24 ± 9% of the day‐to‐day variance in the daytime vertical and zonal drift, respectively, is attributable to conjugate neutral winds. The remaining variance is likely driven by external potentials from non‐conjugate winds and geomagnetic activity (median Kp 2−). Zonal winds at 100–113 km and >120 km altitude are the primary drivers of conjugate vertical and zonal drift variance, respectively. These observations can test vertical‐coupling mechanisms in whole‐atmosphere models.
3D Traveling Ionospheric Disturbances During the 2022 Hunga Tonga–Hunga Ha’apai Eruption Using GNSS TEC
Authors: Cahyadi Mokhamad Nur , Muslim Buldan , Muafiry Ihsan Naufal , Gusman Aditya Riadi , Handoko Eko Yuli , Anjasmara Ira Mutiara , Putra Meilfan Eka , Wulansari Mega , Lestari Dwi Sri , Jin Shuanggen , Sri Sumantyo Josaphat Tetuko 
Published: March 2024

AbstractThe dual frequency Global Navigation Satellite System (GNSS) observations could determine the total electron content (TEC) in the ionosphere. In this study, GNSS TEC was applied to detect traveling ionospheric disturbances (TIDs) after the eruption of Hunga Tonga–Hunga Ha’apai (HTHH) on 15 January 2022. The eruption caused two types of tsunamis, first is tsunami generated by atmospheric wave (meteo‐tsunami) and second is caused by eruption induces water displacement or tsunami classic. At the same time with former tsunami, the atmospheric wave (shock and lamb waves) also caused TIDs at a speed of approximately ∼0.3 km/s. We found moderate correlation between this TIDs amplitude and the tsunami wave height model from tide gauge stations in New Zealand (0.64) and Australia (0.65). Further we attempted to reveal 3D structure of the TIDs in New Zealand, South Australia, and Philippines using 3D tomography. The tomography was set up > 1,170 blocks, as large as 1.0° (east–west) × 1.0° (north–south) × 100 km (vertical), up to 600 km altitude over selected regions. Tomogram shows beautiful concentric directivity of the first TIDs generated by atmospheric wave (AW).
The Martian Ionospheric Response to the Co‐Rotating Interaction Region That Caused the Disappearing Solar Wind Event at Mars
Authors: Shaver S. R. , Solt L. , Andersson L. , Halekas J. , Jian L. , da Silva D. E. , Jolitz R. , Malaspina D. , Fowler C. M. , Ramstad R. , Lillis R. , Xu S. , Azari A. R. , Mazelle C. , Rahmati A. , Lee C. O. , Hesse T. , Hamil O. , Pilinski M. , Brain D. , Garnier P. , Cravens T. E. , McFadden J. P. , Hanley K. G. , Mitchell D. L. , Espley J. R. , Gruesbeck J. R. , Larson D. , Curry S. 
Published: March 2024

AbstractAn unusually low density solar wind event was observed in December 2022 moving past both Earth and Mars. The source was traced back to a coronal hole and active region on the Sun's surface. The resulting solar wind lead to the development of a co‐rotating interaction region (CIR) and trailing rarefaction region that lasted for multiple solar rotations. Within this structure, the solar wind conditions, including density, velocity, and magnetic field magnitude and orientation drastically changed. In this study we analyze the response of the Martian ionosphere using MAVEN data to these changing solar wind conditions. The low density solar wind region associated with the December event resulted in the expansion of the Martian ionospheric boundaries. We show that the ion composition boundary (ICB) is located at extreme altitudes that are beyond previously observed locations from the MAVEN mission between 2015 and 2018. Furthermore, the boundary between shocked solar wind and the Martian ionosphere identified using electron and ion data moved together on the dayside of the planet with the changing solar wind conditions. However, at the flank region these boundaries do not move together, and we show here that the decoupling of the two boundaries may be the result of a change in the interplanetary magnetic field azimuthal angle.
F1 Region Ion Composition in Svalbard During the International Polar Year 2007–2008
Authors: Virtanen Ilkka I. , Tesfaw Habtamu W. , Aikio Anita T. , Varney Roger , Kero Antti , Thomas Neethal 
Published: March 2024

AbstractIons in the F region ionosphere at 150–400 km altitude consist mainly of molecular NO+ and , and atomic O+. Incoherent scatter (IS) radars are sensitive to the molecular‐to‐atomic ion density ratio, but its effect to the observed incoherent scatter spectra is almost identical with that of the ion temperature. It is thus very difficult to fit both the ion temperature and the fraction of O+ ions to the observed spectra. In this paper, we introduce a novel combination of Bayesian filtering, smoothness priors, and chemistry modeling to solve for F1 region O+ ion fraction from EISCAT Svalbard IS radar (75.43° corrected geomagnetic latitude) data during the international polar year (IPY) 2007–2008. We find that the fraction of O+ ions in the F1 region ionosphere is controlled by ion temperature and electron production. The median value of the molecular‐to‐atomic ion transition altitude during IPY varies from 187 km at 16–17 MLT to 208 km at 04–05 MLT. The ion temperature has maxima at 05–06 MLT and 15–16 MLT, but the transition altitude does not follow the ion temperature, because photoionization lowers the transition altitude. A daytime transition altitude maximum is observed in winter, when lack of photoionization leads to very low daytime electron densities. Both ion temperature and the molecular‐to‐atomic ion transition altitude correlate with the Polar Cap North geomagnetic index. The annual medians of the fitted transition altitudes are 14–32 km lower than those predicted by the International Reference Ionosphere.
Thousand‐Kilometer DAS Array Reveals an Uncatalogued Magnitude‐5 Dynamically Triggered Event After the 2023 Turkey Earthquake
Authors: Zhai Qiushi , Zhan Zhongwen , Chavarria J. Andres 
Published: March 2024

AbstractLarge earthquakes can trigger smaller seismic events, even at significant distances. The process of earthquake triggering offers valuable insights into the evolution of local stress states, deepening our understanding of the mechanisms of earthquake nucleation. However, our ability to detect these triggered events is limited by the quality and spatial density of local seismometers, posing significant challenges if the triggered event is hidden in the signal of a nearby larger earthquake. Distributed acoustic sensing (DAS) has the potential to enhance the monitoring capability of triggered earthquakes through its high spatial sampling and large spatial coverage. Here, we report on an uncatalogued magnitude (M) 5.1 event in northeast Turkey, which was likely dynamically and instantaneously triggered by the 2023 M7.8 earthquake in southeast Turkey, located 400 km away. This event was initially discovered on ∼1,100 km of active DAS recordings that are part of an 1,850‐km linear array. Subsequent validation using local seismometers confirmed the event's precise time, location, and magnitude. Interestingly, this dynamically triggered event exhibited precursory signals preceding its P arrivals on the nearby seismometers. It can be interpreted as the signal from other nearby, uncatalogued, smaller triggered events. Our results highlight the potential of high‐spatial‐density DAS in enhancing the local‐scale detection and the detailed analysis of earthquake triggering.
The Timescale and Carbon Flux Recorded by Skarn Garnet From Gangdese Arc, Southern Tibet
Authors: Zhou Zhenhao , Chu Xu , Chen Junxing 
Published: March 2024

AbstractContact metamorphism of carbonate rocks in response to fluid infiltration releases carbon dioxide (CO2), potentially affecting Earth's carbon budget over geological timescales. This process was notably active in the Cretaceous when the closure of the Neo‐Tethys Ocean led to extensive arc magmatism in southern Tibet, coincident with a greenhouse climate interval. These arc plutons intersected carbonate sequences and formed widespread calcsilicate rocks. The mineral assemblages of these rocks record both the progression and duration of the CO2 release. In this study, we focus on a representative aureole in southern Tibet that was metamorphosed by a ∼64 Ma granitoid pluton of the Gangdese Batholith. The aureole presents lithologic zonation, with the inner garnet‐wollastonite zone indicating equilibrium with a water‐rich fluid at ∼525°C. Large garnet porphyroblasts feature cross‐cutting veins of secondary garnets that illustrate several stages of interface‐coupled dissolution‐reprecipitation processes facilitated by fluid infiltration. Diffusion modeling for Mg concentration profiles across vein‐host garnet yields a brief high‐temperature stage (25–150 kyr)—a duration still significantly overestimated considering factors that may accelerate diffusion in garnet, such as lattice parameters and hydration. Such short timescale aligns with conduction modeling of a cooling pluton, which, combined with the bulk‐rock mass balance analysis, indicates a local carbon flux comparable to fluxes at other modern tectonic settings. The metamorphic decarbonation, potentially episodic, in the continental arc may have been an important endogenic carbon source in the late Cretaceous.
Exomoon Phase Curves: Toroidal Exosphere Simulations of Exo‐Ios Orbiting 8 Exoplanets in Alkali Spectroscopy
Authors: Meyer zu Westram M. , Oza A. V. , Galli A. 
Published: March 2024

AbstractToroidal atmospheres and exospheres characterized at exoplanets may be fueled by volcanically active exomoons, often referred to as exo‐Ios. We study the neutral outgassing and volatile evolution of a close‐orbiting, evaporating satellite at eight candidate exoplanet‐exomoon systems WASP‐49,‐96,‐69,‐17 b, XO‐2N b, HAT‐P‐1 b, HD‐189733 b, and HD‐209458 b by developing a 3‐D test‐particle Monte Carlo simulation, Simulating the Evolution of Ring Particles Emergent from Natural Satellites. The module is coupled to dishoom, approximating the minimum mass‐flux needed to reproduce observations of alkali line profiles identified in dozens of transmission spectra. We focus on sputtered neutral sodium, limited by photoionization and radiative effects. By considering Earth‐, Io‐, and Enceladus‐like masses, we systematically simulate the imprint of a non‐hydrostatic medium (characteristic of volcanic exospheres) in density and velocity space using a novel Delaunay tesselation field estimator algorithm. Our results demonstrate how exomoons can considerably modulate gas density observations probed near exoplanet transit, depending on the orbital phase of the putative satellite at the time of observation. The density evolution, therefore, manifests on orbital timescales as “exomoon phase curves” from shadow to occultation. We find two regimes of density evolution, characteristic of a: (a) localized cloud and (b) an azimuthally symmetric exoring/torus, degenerate with an exoplanet atmosphere, ranging from ∼109.5±0.5 cm−2 to ∼1015±0.25 cm−2 at our leading candidate WASP‐69b I. In certain orbital architectures, the smallest evaporating satellite mass surprisingly generates the brightest sodium signal, fueling optimism for discovering photometrically indiscernible rocky exomoons. We suggest long baseline monitoring of alkali and SO2 systems in spectroscopy to search for the temporal and spatial variability predicted here.
Nutrient Dynamics in a Coupled Terrestrial Biosphere and Land Model (ELM‐FATES‐CNP)
Authors: Knox Ryan G. , Koven Charles D. , Riley William J. , Walker Anthony P. , Wright S. Joseph , Holm Jennifer A. , Wei Xinyuan , Fisher Rosie A. , Zhu Qing , Tang Jinyun , Ricciuto Daniel M. , Shuman Jacquelyn K. , Yang Xiaojuan , Kueppers Lara M. , Chambers Jeffrey Q. 
Published: March 2024

AbstractWe present a representation of nitrogen and phosphorus cycling in the Functionally Assembled Terrestrial Ecosystem Simulator, a demographic vegetation model within the Energy Exascale Earth System land model. This representation is modular, and designed to allow testing of multiple hypothetical approaches for carbon‐nutrient coupling in plants. Novel model hypotheses introduced in this work include, (a) the controls on plant acquisition of aqueous mineralized nutrients in the soil and (b) fairly straight forward methods of allocating nutrients to specific plant organs and their losses through live plant turnover as well as litter fluxes generated through plant mortality. This combines the new with pre‐existing hypotheses (such as nitrogen fixation and soil decomposition) into a system that can accommodate plant‐soil dynamics for a large number of size‐ and functional‐type‐resolved plant cohorts within a time‐since‐disturbance‐resolved ecosystem. Root uptake of nutrients is governed by fine root biomass, and plants vary in their fine root biomass allocation in order to balance carbon and nutrient limitations to growth. We test the sensitivity of the model to a wide range of parameter variations and structural representations, and in the context of observations at Barro Colorado Island, Panama. A key model prediction is that plants in the high‐light‐availability canopy positions allocate more carbon to fine roots than plants in low‐light understory environments, given the widely different carbon versus nutrient constraints of these two niches within a given ecosystem. This model provides a basis for exploring carbon‐nutrient coupling with vegetation demography within Earth system models.
Urbanization Further Intensifies Short‐Duration Rainfall Extremes in a Warmer Climate
Authors: Yan Haochen , Gao Yao , Wilby Robert , Yu Dapeng , Wright Nigel , Yin Jie , Chen Xunlai , Chen Ji , Guan Mingfu 
Published: March 2024

AbstractIntensification of short‐duration rainfall extremes contributes to increased urban flood risk. Yet, it remains unclear how upper‐tail rainfall statistics could change with regional warming. Here, we characterize the non‐stationarity of rainfall extremes over durations of 1–24 hr for the rapidly developing coastal megalopolis of the Greater Bay Area, China. Using high‐resolution, multi‐source, merged and gridded data we observe greater increases in rainfall intensities over the north‐central part of the region compared with the southern coastal region. Our results show, for the first time, that urbanization nonlinearly increases rainfall intensities at different durations and return periods. Over short durations (≤3‐hr) and short return periods (2‐yr), urban areas have the greatest scaling rates (≥19.9%/°C). However, over longer durations (≥9‐hr) rural areas have greater scaling rates, with a lower degree of dependency on both durations and return periods.
Matrix metalloproteinase 9 (MMP-9) activity, hippocampal extracellular free water, and cognitive deficits are associated with each other in early phase psychosis
Authors: Seitz-Holland Johanna , Alemán-Gómez Yasser , Cho Kang Ik K. , Pasternak Ofer , Cleusix Martine , Jenni Raoul , Baumann Philipp S. , Klauser Paul , Conus Philippe , Hagmann Patric , Do Kim Q. , Kubicki Marek , Dwir Daniella 
Published: March 2024

AbstractIncreasing evidence points toward the role of the extracellular matrix, specifically matrix metalloproteinase 9 (MMP-9), in the pathophysiology of psychosis. MMP-9 is a critical regulator of the crosstalk between peripheral and central inflammation, extracellular matrix remodeling, hippocampal development, synaptic pruning, and neuroplasticity. Here, we aim to characterize the relationship between plasma MMP-9 activity, hippocampal microstructure, and cognition in healthy individuals and individuals with early phase psychosis. We collected clinical, blood, and structural and diffusion-weighted magnetic resonance imaging data from 39 individuals with early phase psychosis and 44 age and sex-matched healthy individuals. We measured MMP-9 plasma activity, hippocampal extracellular free water (FW) levels, and hippocampal volumes. We used regression analyses to compare MMP-9 activity, hippocampal FW, and volumes between groups. We then examined associations between MMP-9 activity, FW levels, hippocampal volumes, and cognitive performance assessed with the MATRICS battery. All analyses were controlled for age, sex, body mass index, cigarette smoking, and years of education. Individuals with early phase psychosis demonstrated higher MMP-9 activity (p < 0.0002), higher left (p < 0.05) and right (p < 0.05) hippocampal FW levels, and lower left (p < 0.05) and right (p < 0.05) hippocampal volume than healthy individuals. MMP-9 activity correlated positively with hippocampal FW levels (all participants and individuals with early phase psychosis) and negatively with hippocampal volumes (all participants and healthy individuals). Higher MMP-9 activity and higher hippocampal FW levels were associated with slower processing speed and worse working memory performance in all participants. Our findings show an association between MMP-9 activity and hippocampal microstructural alterations in psychosis and an association between MMP-9 activity and cognitive performance. Further, more extensive longitudinal studies should examine the therapeutic potential of MMP-9 modulators in psychosis.
High-density volumetric super-resolution microscopy
Authors: Daly Sam , Ferreira Fernandes João , Bruggeman Ezra , Handa Anoushka , Peters Ruby , Benaissa Sarah , Zhang Boya , Beckwith Joseph S. , Sanders Edward W. , Sims Ruth R. , Klenerman David , Davis Simon J. , O’Holleran Kevin , Lee Steven F. 
Published: March 2024

AbstractVolumetric super-resolution microscopy typically encodes the 3D position of single-molecule fluorescence into a 2D image by changing the shape of the point spread function (PSF) as a function of depth. However, the resulting large and complex PSF spatial footprints reduce biological throughput and applicability by requiring lower labeling densities to avoid overlapping fluorescent signals. We quantitatively compare the density dependence of single-molecule light field microscopy (SMLFM) to other 3D PSFs (astigmatism, double helix and tetrapod) showing that SMLFM enables an order-of-magnitude speed improvement compared to the double helix PSF by resolving overlapping emitters through parallax. We demonstrate this optical robustness experimentally with high accuracy ( > 99.2 ± 0.1%, 0.1 locs μm−2) and sensitivity ( > 86.6 ± 0.9%, 0.1 locs μm−2) through whole-cell (scan-free) imaging and tracking of single membrane proteins in live primary B cells. We also exemplify high-density volumetric imaging (0.15 locs μm−2) in dense cytosolic tubulin datasets.
Diverging effects of host density and richness across biological scales drive diversity-disease outcomes
Authors: Johnson Pieter T. J. , Stewart Merrill Tara E. , Dean Andrew D. , Fenton Andy 
Published: March 2024

AbstractUnderstanding how biodiversity affects pathogen transmission remains an unresolved question due to the challenges in testing potential mechanisms in natural systems and how these mechanisms vary across biological scales. By quantifying transmission of an entire guild of parasites (larval trematodes) within 902 amphibian host communities, we show that the community-level drivers of infection depend critically on biological scale. At the individual host scale, increases in host richness led to fewer parasites per host for all parasite taxa, with no effect of host or predator densities. At the host community scale, however, the inhibitory effects of richness were counteracted by associated increases in total host density, leading to no overall change in parasite densities. Mechanistically, we find that while average host competence declined with increasing host richness, total community competence remained stable due to additive assembly patterns. These results help reconcile disease-diversity debates by empirically disentangling the roles of alternative ecological drivers of parasite transmission and how such effects depend on biological scale.
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing
Authors: Zarou Martha M. , Rattigan Kevin M. , Sarnello Daniele , Shokry Engy , Dawson Amy , Ianniciello Angela , Dunn Karen , Copland Mhairi , Sumpton David , Vazquez Alexei , Helgason G. Vignir 
Published: March 2024

AbstractSupporting cell proliferation through nucleotide biosynthesis is an essential requirement for cancer cells. Hence, inhibition of folate-mediated one carbon (1C) metabolism, which is required for nucleotide synthesis, has been successfully exploited in anti-cancer therapy. Here, we reveal that mitochondrial folate metabolism is upregulated in patient-derived leukaemic stem cells (LSCs). We demonstrate that inhibition of mitochondrial 1C metabolism through impairment of de novo purine synthesis has a cytostatic effect on chronic myeloid leukaemia (CML) cells. Consequently, changes in purine nucleotide levels lead to activation of AMPK signalling and suppression of mTORC1 activity. Notably, suppression of mitochondrial 1C metabolism increases expression of erythroid differentiation markers. Moreover, we find that increased differentiation occurs independently of AMPK signalling and can be reversed through reconstitution of purine levels and reactivation of mTORC1. Of clinical relevance, we identify that combination of 1C metabolism inhibition with imatinib, a frontline treatment for CML patients, decreases the number of therapy-resistant CML LSCs in a patient-derived xenograft model. Our results highlight a role for folate metabolism and purine sensing in stem cell fate decisions and leukaemogenesis.
fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles
Authors: Dennhag Nils , Kahsay Abraha , Nissen Itzel , Nord Hanna , Chermenina Maria , Liu Jiao , Arner Anders , Liu Jing-Xia , Backman Ludvig J. , Remeseiro Silvia , von Hofsten Jonas , Pedrosa Domellöf Fatima 
Published: March 2024

AbstractIn muscular dystrophies, muscle fibers loose integrity and die, causing significant suffering and premature death. Strikingly, the extraocular muscles (EOMs) are spared, functioning well despite the disease progression. Although EOMs have been shown to differ from body musculature, the mechanisms underlying this inherent resistance to muscle dystrophies remain unknown. Here, we demonstrate important differences in gene expression as a response to muscle dystrophies between the EOMs and trunk muscles in zebrafish via transcriptomic profiling. We show that the LIM-protein Fhl2 is increased in response to the knockout ofdesmin,plectinandobscurin, cytoskeletal proteins whose knockout causes different muscle dystrophies, and contributes to disease protection of the EOMs. Moreover, we show that ectopic expression offhl2bcan partially rescue the muscle phenotype in the zebrafish Duchenne muscular dystrophy modelsapje, significantly improving their survival. Therefore, Fhl2 is a protective agent and a candidate target gene for therapy of muscular dystrophies.