bluuebunny/crossref_metadata_2025_split huggingface dataset:
The results of the cross-sectional study of platelet aggregative function in children with hemorrhagic syndrome
Authors: Gordeeva Olga B. , Dobrotok Albina V. , Volkova Mariia V. , Aleshenko Natalia L. , Kargin Vladimir S. , Dzharkava Irine , Zhdanovskaia Nadezhda F. 
Published: February 2024

Background. Early diagnosis of thrombocytopathies in children is a relevant objective of pediatrics. Diagnostics helps prevent the development of bleeding, chronic posthemorrhagic anemia, reduces the risk of thrombosis.The aim of the study is an assessment of the incidence of platelet aggregation disorders in children with manifestations of hemorrhagic syndrome against the background of chronic pathology.Methods. The study was conducted on the basis of the Research Institute of Pediatrics and Children’s Health, Scientific Center No. 2, Petrovsky National Research Centre of Surgery in the period from January — until December 2022. 62 children were included in the study, of which 50 children were selected (21 boys and 29 girls) aged 2 years 3 months to 17 years 11 months. The median age was 9.4 (7.2; 13.4). Aggregometry was performed using an impedance semiautomatic aggregometer in whole blood.Results. Depending on the diagnosis, the children were divided into the following groups: cardiovascular diseases (CVD), lysosomal storage disorders (LSD), monogenic hereditary diseases (MHD), children with dysplastic syndrome (DS), children with pathology of the nervous system (NS). Hypoaggregation with thrombin-activating peptide (TRAP test) was detected in 28% of cases (n = 14), more often in children from the group with MHD — 10% (n = 5) and with the presenceof DS — 10% (n = 5). Hypoaggregation with adenosine diphosphate (ADP test) was detected in 20% of cases (n = 10), with arachidonic acid (ASPI test) was detected in 14% (n = 7). Hyperaggregation with the TRAP test was detected in 12% (n = 6), with the ADP test detected in 8% of cases (n = 4). Hyperaggregation with ASPI test was detected in 18% of cases (n = 9).Conclusion. The analyzed results of laboratory tests of platelet aggregation function, hypoaggregation with inducers was observed in more than half of the children, hyperaggregation was observed was present in almost half of the patients.
Implementation study to introduce clinical guidelines on lipid metabolism disorders into routine practice: results of the first stage
Authors: Alieva A. S. , Usova E. I. , Zvartau N. E. , Shlyakhto E. V. 
Published: February 2024

Despite widespread knowledge in the management of patients with lipid metabolism disorders, their application in clinical practice is insufficient. Identification of barriers to the implementation of key principles of clinical guidelines in routine practice is the first step of the implementation study.Aim. To assess the organization and quality of care for patients with dyslipidemia in order to identify barriers to the implementation of the main principles of clinical guidelines in practice.Material and methods. An implementation study was planned, the initial stage of which was to conduct an anonymous online questionnaire among health care representatives of various levels in all Russian subjects.Results. The study involved 788 physicians, 124 heads of medical organizations and 48 chief freelance specialists from 84 Russian subjects. A wide range of barriers was identified: low availability of lipoprotein (a) testing (66,6% of physicians), coronary calcium index (79,4% of physicians, 71,8% of heads of a medical organizations, 79,2% of chief freelance specialists) and CT angiography (70,0% of physicians, 71,0% of heads of a medical organizations, 85,4% of chief freelance specialists). Lack of funds to manage lipid service (55,6% of heads of a medical organizations, 35,4% of chief freelance specialists). The key barrier to regular lipid-lowering therapy and achieving target low-density lipoprotein cholesterol (LDL-C) levels is lack of perceived need for treatment in patients (58,1% of physicians, 80,0% of heads of a medical organizations, 87,5% of chief freelance specialists), for PCSK9-targeted therapy — high cost (44,1% of physicians, 34,7% of heads of a medical organizations, 23,0% of chief freelance specialists). The possible fixed-dose combination therapy for dyslipidemia was positively perceived (59,7% of physicians, 42,0% of heads of a medical organizations, 35,4% of chief freelance specialists). Inclusion of innovative therapy in medicine assistance program will improve the situation in achieving target LDL-C levels (85,6% of physicians, 91,1% of heads of a medical organizations, 95,8% of chief freelance specialists).Conclusion. A wide range of barriers to the implementation of clinical guidelines on lipid metabolism disorders into practice have been identified. Based on the results obtained, the second stage of the implementation study will identify strategies aimed at eliminating the identified barriers.
Cardiometabolic risk factors in patients with type 2 diabetes and sarcopenia
Authors: Samoilova Yu. G. , Matveeva M. V. , Khoroshunova E. A. , Podchinenova D. V. , Maksimova L. L. , Gorbach G. G. , Trivozhenko A. B. , Avkhimenko V. A. 
Published: February 2024

Aim. To analyze risk factors for sarcopenia in atherosclerosis involvement of target organs in patients with type 2 diabetes (T2D).Material and methods. The study included 84 patients with T2D, divided into groups according to the 2019 criteria of the European Working Group on Sarcopenia in Older People (EWGSOP2). All patients were surveyed using a 36-item short-form health survey (SF-36), Sarcopenia and Quality of Life (SarQoL), Strength, Assistance with walking, Rise from a chair, Climb stairs and Falls (SARC-F), grip test, 4-meter walk test, bioelectrical impedance analysis, 24-hour blood pressure monitoring and cardiac ultrasound. Differences were considered significant at p<0,05.Results. Patients with sarcopenia have lower levels of fat, muscle, cell mass, appendicular mass index, fluid, protein, and minerals. In the group with sarcopenia, higher levels of total cholesterol, low-density lipoprotein cholesterol, glycated hemoglobin, and hypocalcemia were detected. Triglyceride levels were high in those with presarcopenia. In the same group, unstable blood pressure, increased myocardial mass and severe lower limb atherosclerosis were recorded.Conclusion. Sarcopenia is one of the important medical and social problems and is accompanied by unfavorable outcomes. The combination of sarcopenia and T2D can contribute to the rapid development of macro- and microangiopathy and increase the cardiovascular risk.
Cardiovascular complications in non-cardiac surgery: what remains out of sight?
Authors: Murashko S. S. , Berns S. A. , Pasechnik I. N. 
Published: February 2024

Aim. To evaluate any cardiovascular abnormalities in the postoperative period, their prevalence and impact on the course of postoperative period in patients after non-cardiac surgery, which underwent postoperative examinations of cardiovascular system.Material and methods. The study included 2937 patients. The assessed end points were postoperative cardiovascular events (CVEs). Along with major adverse cardiovascular events (MACE), we analyzed any cardiovascular abnormalities in the postoperative period as follows: electrocardiographic ST-T abnormalities, acute or decompensated heart failure (HF), arrhythmias, episodes of hypotension or hypertension, bleeding, thromboembolic events (TEEs), cerebrovascular events, postoperative delirium. Any CVEs constituted the any cardiovascular events' (ACVEs) group. Statistical analysis was carried out using the StatTech v program. 3.1.6 (OOO Stattekh, Russia).Results. Any postoperative complications according to the Clavien-Dindo classification were 54,7%, while grade 1 — 33,9%, grade 2 — 20,3%, grade 3 — 1 case, grade 4 — 0,4%, grade 5 — 0,1%. MACEs developed in 0,2% of cases. ACVEs amounted to 13,3%, including 2,3% — ST-T abnormalities, 6,3% — significant systolic blood pressure changes, 2,6% — arrhythmias, 0,7% — HF, 2,4% — bleeding, 1,1% — TEEs, 0,3% — delirium. In addition, 67 (17,5%) patients had ≥2 CVEs. Comparison of the length of hospital stay of patients with ACVEs, in particular with MACEs, ECG ST-T abnormalities, HF, arrhythmia, episodes of hypotension or hypertension, bleeding, TEEs, cerebrovascular events, delirium, with groups of patients without such complications revealed significant differences. ACVEs accounted for 1/4 of all postoperative complications and 2/3 of complications of grades 2-5.Conclusion. We expanded the concept of CVEs, united the totality of any cardiovascular abnormalities in the postoperative period, emphasized not only their clinical significance, but also the economic feasibility of taking into account ACVEs.
Epicardial fat and left atrial mechanical dispersion in patients with hypertension with persistent atrial fibrillation and without cardiac arrhythmia
Authors: Mazur E. S. , Mazur V. V. , Bazhenov N. D. , Nilova O. V. , Nikolaeva T. O. 
Published: February 2024

Aim. To study the relationship between the amount of epicardial left atrial fat and left atrial mechanical dispersion (LAMD) in hypertensive patients with persistent atrial fibrillation (AF) and without cardiac arrhythmias.Material and methods. The main group included 100 hypertensive patients with persistent AF, who underwent transesophageal echo cardiography (TEE) before the elective cardioversion, and transthoracic echocardiography (TTE) after cardioversion and disappearance of atrial stunning. The control group included 24 hypertensive patients without cardiac arrhythmias, who underwent TEE for other indication. The thickness of atrial septum and left lateral ridge was measured by TEE. The average thickness of these structures was designated as left atrial fat. The time to peak of longitudinal myocardial strain in 6 left atrium segments was determined by speckle-tracking echocardiography. LAMD was calculated as a percentage of the standard deviation of the obtained values to cardiac cycle duration.Results. The median left atrial fat thickness in the main and control groups was 8,03 [6,78; 8,95] and 5,23 [4,48; 5,80] mm (p<0,0001), median LAMD — 2,68 [2,41; 2,83] and 0,95 [0,62; 1,11]% (p<0,0001). There was a positive correlation between left atrial fat thickness and LAMD in the main group (r=0,556; p<0,0001). This relationship did not reach the level of statistical significance in the control group, (r=0,358; p=0,0860). There was no independent relationship between body mass index and left atrial fat thickness in the patients (r=0,027; p=0,7651).Conclusion. In hypertensive patients with persistent AF, compared with patients without rhythm disturbances, the average values of left atrial fat thickness and LAMD are significantly higher. The increase in left atrial fat thickness is associated with the increase in LAMD in hypertensive patients with AF. There was no correlation between left atrial fat thickness and LAMD in hypertensive patients without rhythm disturbances. There was no effect of body mass index on left atrial fat thickness in the present study.
Stress coping strategies — novel markers in the diagnosis of masked hypertension in young people
Authors: Shevchenko A. O. , Yufereva Yu. M. , Gerasimova Yu. A. , Timofeev R. G. , Faradzhov R. A. 
Published: February 2024

Aim. To establish the prevalence and markers of masked hypertension (HTN) in apparently healthy young people.Material and methods. The cross-sectional study included young people (20-30 years old) with health group I or II, with clinical blood pressure (BP) <140/90 mm Hg. All participants underwent 24-hour blood pressure monitoring, assessment of traditional cardiovascular risk factors and ways of coping with stress.Results. A total of 347 participants were included (mean age, 22 (21-23) years; male, 101 (29,1%)). After 24-hour blood pressure monitoring, masked HTN was detected in 46 (13,3%) participants. Multivariate analysis found following markers of masked HTN: office systolic blood pressure (adjusted odds ratio (AOR) 1,109; p<0,001), resting heart rate (AOR 1,051; p=0,021), body mass index ≥25 kg/m2 (AOR 2,345; p=0,039), two models of coping with stress — distancing (AOR 1,071; p=0,001) and self-control (AOR 0,951; p=0,012). These parameters are included in the formula for calculating the masked HTN probability.Conclusion. Masked HTN occurs in 13,3% of apparently healthy young people. Associations of masked HTN with strategies for coping with stress have been established, which allows them to be regarded as novel markers of masked HTN. The method described in the article makes it possible to identify masked HTN with a high probability in young people.
Psychological impact and development of autistic traits in children during the COVID 19 Pandemic: A study through Guardian
Authors: Iqbal Waseem , Hassan Mudassir , Mir Parveez Ahmed , Kaiser Syed 
Published: February 2024

The COVID 19 pandemic has significantly affected people's lives worldwide. Although children may not experience severe physical symptoms of the disease, their psychological well-being can be greatly affected. The primary objective of this study was to examine the psychological impact of COVID-19 on children residing in the Kashmir valley in terms of evolution of autistic traits in them. Cross-sectional study was conducted amongst 300 family members of children aged between 4 to 16-years. Data was collected through an online questionnaire using Google Forms and purposive sampling technique was used to assess autism. The sample for the study consisted of children in the 4 year to 16-year age group. A self-designed validated questionnaire in Google Form was used to collect the information. Chidhood Autism Rating Scale-2 (CARS-2) was used in those with excessive mobile phone usage. The results of the study revealed that only 3% of the children were infected with COVID-19. 7% of the sample reported that a close family member of a child was infected. Furthermore, 76% of the sample reported that they discussed COVID-19 with their children. In terms of behavioral changes, 54% of the sample noticed a change in their child's behaviour during the COVID pandemic. Additionally, 51% reported a change in their children's learning patterns, and 48% reported that their child had become possessive about new things since the pandemic. Furthermore, 35% of the sample reported a change in their child's sleeping cycle, 22.7% reported a loss of appetite, and 56% reported that their child imagined and talked about COVID-19 with others. It was also found that 80.3% of the sample had adhered to COVID-19 precautions. Only 4.3% reported negative thoughts expressed by their children since the pandemic, while 88% reported that their children were ready to discuss in future COVID-19. In the 4 to 6 year age group, out of 12 children with excessive mobile phone use, it was found that two were having symptoms consistent with Autism Spectrum Disorder. Other common symptoms noticed in this age group were found to be clapping, single verbal sounds, inability to express needs, moderate abnormal listening response, echolalia and video dialoguing. Most families reported that their children were possessive about new things and most of them were not sitting at one place for a long time. A large percentage of families reported that they found changes in the sleep pattern and duration of sleep was more than 9 hours. It was also found that screen time during COVID-19 increased among school-going children.
Cash Wakaf Cash Waqf Behavior Supports Mental Health And Community Economy
Authors: Ritawati Raden Ayu , Septiana Raden Ayu Erika 
Published: February 2024

Cash waqf is the main potential in driving people's economic behavior. Its presence is also a solution in overcoming all mental health and economic problems of the ummah. Various Muslim countries in the world have implemented the potential of this cash waqf to overcome various healthy dan economic problems. Utilization of cash waqf can be carried out both productively and non-productively in various interests for the healthy and welfare of the community in general. Nazhir's role is central in cash waqf. The nature of cash waqf is not an obligation. Money as a basic asset (ashal/mauquf alaih) cannot be reduced or used up. Money must be transferred into productive assets that flow many benefits in a sustainable manner.
This qualitative research seeks to provide a descriptive discourse on the application of contemporary fiqh. Where cash waqf can be managed with productive investment schemes such as mudharabah, musyarakah, ijârah and murabaha. All of this with the intention of profitably benefiting both parties. Then this profit will be used for the mental health and benefit of society at large while maintaining the basic value of the waqf property. While non-productive management can be carried out by constructing buildings/buildings as socio-religious infrastructure, such as places of worship, educational facilities, health, plantations, fisheries and other social facilities. While the management of financial services can be collaborated with other public financial sources such as the use of zakat, infaq and alms funds whose management is utilized for the benefit of increasing the welfare of the community in general.
Peran Guru Bimbingan dan Konseling dalam Mengatasi Perilaku Agresif melalui Konseling Individual
Authors: Krismonia Timi 
Published: February 2024

Penelitian ini bertujuan untuk guru BK agar dapat memahami akar masalah yang mendasari perilaku agresif siswa secara lebih mendalam. Melalui sesi konseling individual, guru BK dapat memberikan ruang yang aman bagi siswa untuk berbicara tentang pengalaman dan perasaan mereka. Penelitian ini menggunakan metode deskriptif kualitatif dengan penentuan informan melalui Teknik purposive sampling, yaitu wali kelas dan guru bimbingan konseling sebagai subjek dan objek. Instrumen penelitian mencakup wawancara, observasi, dan dokumentasi. Pengolahan data menggunakan triangulasi data. Perilaku agresif diartikan sebagai tindakan yang dapat menyakiti hati dan merugikan diri sendiri serta orang lain. Konseling ini difokuskan pada pengembangan pemahaman diri, pengelolaan emosi, dan strategi penyelesaian konflik. Hasil penelitian menunjukkan bahwa 1) perilaku agresif pada peserta didik melibatkan faktor kepribadian kuat dan pandangan bahwa tindakan tersebut wajar, juga kurangnya pengawasan, perhatian, dan kasih sayang dari orang tua. 2) Respon terhadap perilaku agresif melibatkan peran penting guru bimbingan dan konseling, termasuk layanan konseling individu sebagai salah satu strategi penanganan.
NER Sequence Embedding of Unified Medical Corpora to Incorporate Semantic Intelligence in Big Data Healthcare Diagnostics
Authors: Shafqat Sarah , Anwar Zahid , Javaid Qaisar , Ahmad Hafiz Farooq 
Published: February 2024

Abstract
Clinical diagnosis is a challenging task for which high expertise is required at the doctors’ end. It is recognized that technology integration with the clinical domain would facilitate the diagnostic process. A semantic understanding of the medical domain and clinical context is needed to make intelligent analytics. These analytics need to learn the medical context for different purposes of diagnosing and treating patients. Traditional diagnoses are made through phenotype features from patients’ profiles. It is also a known fact that diabetes mellitus (DM) is widely affecting the population and is a chronic disease that requires timely diagnosis. The motivation for this research comes from the gap found in discovering the common ground for medical context learning in analytics to diagnose DM and its comorbidity diseases. Therefore, a unified medical knowledge base is found significantly important to
learning contextual Named Entity Recognition (NER) embedding for semantic intelligence. Researchers in this paper have searched for possible solutions for medical context learning and found that unified corpora tagged with medical terms were missing to train the analytics for diagnoses of DM and its
comorbidities. Hence, effort was put into collecting endocrine diagnostic electronic health records (EHR) corpora for clinical purposes that are manually labeled with ICD-10-CM international coding scheme to minimise chances of error. International Codes for Diseases (ICD) by the World Health Organization (WHO) is a known schema to represent medical codes for diagnoses. The complete endocrine EHR corpora make DM-Comorbid-EHR-ICD-10 Corpora. DM-Comorbid-EHR-ICD-10 Corpora is tagged for understanding the medical context with uniformity. In this research experiments were run with different NER sequence embedding approaches using advanced ML integrated with NLP techniques. These experiments used common frameworks like; Spacy, Flair, and TensorFlow, Keras. These experiments led to yield albeit label sets in the form of (instance, label) pair for diagnoses that were tagged with the Sequential() model found in TensorFlow.Keras using Bi-LSTM and dense layers.
The maximum accuracy achieved was 0.9 for Corpus14407_DM_pts_33185 with a maximum number of diagnostic features taken as input. The sequential DNN NER model diagnostic accuracy increased as the size of the corpus grew from 100 to 14407 DM patients suffering from comorbidity diseases. The
significance of clinical notes and practitioner comments available as free text is clearly seen in the diagnostic accuracy.