bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinguishing pure and thermal states by Landauer’s principle in open systems
Authors: Xu Hao 
Published: April 2024

AbstractStarting from Polchinski’s thought experiment on how to distinguish between pure and thermal states, we construct a specific system to study the interaction between qubit and cavity quantum field theory (QFT) in order to provide a more operational point of view. Without imposing any restrictions on the initial states of qubit and cavity QFT, we compute the evolution of the system order by order by the perturbation method. We choose Landauer’s principle, an important bound in quantum computation and quantum measurement, as the basis for the determination of the thermal state. By backtracking the initial state form, we obtain the conditions that must be satisfied by the cavity QFT: the expectation value of the annihilation operator should be zero, and the expectation value of the particle number operator should satisfy the Bose–Einstein distribution. We also discuss the difference between the thermal state and a possible alternative to the thermal state: the canonical thermal pure quantum (CTPQ) state.
Unveiling the silent majority: stance detection and characterization of passive users on social media using collaborative filtering and graph convolutional networks
Authors: Zhou Zhiwei , Elejalde Erick 
Published: April 2024

AbstractSocial Media (SM) has become a popular medium for individuals to share their opinions on various topics, including politics, social issues, and daily affairs. During controversial events such as political elections, active users often proclaim their stance and try to persuade others to support them. However, disparities in participation levels can lead to misperceptions and cause analysts to misjudge the support for each side. For example, current models usually rely on content production and overlook a vast majority of civically engaged users who passively consume information. These “silent users” can significantly impact the democratic process despite being less vocal. Accounting for the stances of this silent majority is critical to improving our reliance on SM to understand and measure social phenomena. Thus, this study proposes and evaluates a new approach for silent users’ stance prediction based on collaborative filtering and Graph Convolutional Networks, which exploits multiple relationships between users and topics. Furthermore, our method allows us to describe users with different stances and online behaviors. We demonstrate its validity using real-world datasets from two related political events. Specifically, we examine user attitudes leading to the Chilean constitutional referendums in 2020 and 2022 through extensive Twitter datasets. In both datasets, our model outperforms the baselines by over 9% at the edge- and the user level. Thus, our method offers an improvement in effectively quantifying the support and creating a multidimensional understanding of social discussions on SM platforms, especially during polarizing events.
Statins Do Not Significantly Affect Oxidative Nitrosative Stress Biomarkers in the PREVENT Randomized Clinical Trial
Authors: Makhlin Igor , Demissei Biniyam G. , D'Agostino Ralph , Hundley W. Greg , Baleanu-Gogonea Camelia , Wilcox Nicholas S. , Chen Anna , Smith Amanda M. , O'Connell Nathaniel Sean , Januzzi James L. , Lesser Glenn J. , Scherrer-Crosbie Marielle , Ibáñez Borja , Tang W.H. Wilson , Ky Bonnie 
Published: April 2024

Abstract

Purpose:
Preventing Anthracycline Cardiovascular Toxicity with Statins (PREVENT; NCT01988571) randomized patients with breast cancer or lymphoma receiving anthracyclines to atorvastatin 40 mg daily or placebo. We evaluated the effects of atorvastatin on oxidative and nitrosative stress biomarkers, and explored whether these biomarkers could explain the lack of effect of atorvastatin on LVEF (left ventricular ejection fraction) in PREVENT.

Patients and Methods:
Blood samples were collected and cardiac MRI was performed before doxorubicin initiation and at 6 and 24 months. Thirteen biomarkers [arginine–nitric oxide metabolites, paraoxonase-1 (PON-1) activity, and myeloperoxidase] were measured. Dimensionality reduction using principal component analysis was used to define biomarker clusters. Linear mixed-effects models determined the changes in biomarkers over time according to treatment group. Mediation analysis determined whether biomarker clusters explained the lack of effect of atorvastatin on LVEF.

Results:
Among 202 participants with available biomarkers, median age was 53 years; 86.6% had breast cancer; median LVEF was 62%. Cluster 1 levels, reflecting arginine methylation metabolites, were lower over time with atorvastatin, although this was not statistically significant (P = 0.081); Cluster 2 levels, reflecting PON-1 activity, were significantly lower with atorvastatin (P = 0.024). There were no significant changes in other biomarker clusters (P &gt; 0.05). Biomarker clusters did not mediate an effect of atorvastatin on LVEF (P &gt; 0.05).

Conclusions:
Atorvastatin demonstrated very modest effects on oxidative/nitrosative stress biomarkers in this low cardiovascular risk population. Our findings provide potential mechanistic insight into the lack of effect of atorvastatin on LVEF in the PREVENT trial.
A vanguarda intelectual da atuação profissional de Jorge O. Caron (1973–1984)
Authors: Monteiro Ana Maria Reis de Góes , Vidotto Taiana Car 
Published: April 2024

Throughout his lifetime, Jorge Osvaldo Caron (1936 - 2000) experienced the intrinsic conecction between teaching at schools of architecture and as an active architect in professional institutions. In this sense, this article aims to present Caron’s path between 1973, when he started his work in the São Paulo State Architects Union - SASP, until 1984, when he left the course at Fundação Educacional Belas Artes de São Paulo - FEBASP. This period considers the expansion of architecture schools during the Military Regime and the joint action of professional institutions, in which Caron was one of the agents participating from an intense debate on the relationship between teaching and the profession.
HMGB2 Release Promotes Pulmonary Hypertension and Predicts Severity and Mortality of Patients With Pulmonary Arterial Hypertension
Authors: Kong Deping , Liu Jing , Lu Junmi , Zeng Cheng , Chen Hao , Duan Zhenzhen , Yu Ke , Zheng Xialei , Zou Pu , Zhou Liufang , Lv Yicheng , Zeng Qingye , Lu Lin , Li Jiang , He Yuhu 
Published: April 2024

BACKGROUND:
Pulmonary hypertension (PH) is a progressive and life-threatening disease characterized by pulmonary vascular remodeling, which involves aberrant proliferation and apoptosis resistance of the pulmonary arterial smooth muscle cells (PASMCs), resembling the hallmark characteristics of cancer. In cancer, the HMGB2 (high-mobility group box 2) protein promotes the pro-proliferative/antiapoptotic phenotype. However, the function of HMGB2 in PH remains uninvestigated.

METHODS:
Smooth muscle cell (SMC)–specific HMGB2 knockout or HMGB2-OE (HMGB2 overexpression) mice and HMGB2 silenced rats were used to establish hypoxia+Su5416 (HySu)-induced PH mouse and monocrotaline-induced PH rat models, respectively. The effects of HMGB2 and its underlying mechanisms were subsequently elucidated using RNA-sequencing and cellular and molecular biology analyses. Serum HMGB2 levels were measured in the controls and patients with pulmonary arterial (PA) hypertension.

RESULTS:
HMGB2 expression was markedly increased in the PAs of patients with PA hypertension and PH rodent models and was predominantly localized in PASMCs. SMC-specific HMGB2 deficiency or silencing attenuated PH development and pulmonary vascular remodeling in hypoxia+Su5416-induced mice and monocrotaline-treated rats. SMC-specific HMGB2 overexpression aggravated hypoxia+Su5416-induced PH. HMGB2 knockdown inhibited PASMC proliferation in vitro in response to PDGF-BB (platelet-derived growth factor-BB). In contrast, HMGB2 protein stimulation caused the hyperproliferation of PASMCs. In addition, HMGB2 promoted PASMC proliferation and the development of PH by RAGE (receptor for advanced glycation end products)/FAK (focal adhesion kinase)-mediated Hippo/YAP (yes-associated protein) signaling suppression. Serum HMGB2 levels were significantly increased in patients with PA hypertension, and they correlated with disease severity, predicting worse survival.

CONCLUSIONS:
Our findings indicate that targeting HMGB2 might be a novel therapeutic strategy for treating PH. Serum HMGB2 levels could serve as a novel biomarker for diagnosing PA hypertension and determining its prognosis.
The Multimodal Trust Effects of Face, Voice, and Sentence Content
Authors: Syed Isar , Baart Martijn , Vroomen Jean 
Published: April 2024

Abstract
Trust is an aspect critical to human social interaction and research has identified many cues that help in the assimilation of this social trait. Two of these cues are the pitch of the voice and the width-to-height ratio of the face (fWHR). Additionally, research has indicated that the content of a spoken sentence itself has an effect on trustworthiness; a finding that has not yet been brought into multisensory research. The current research aims to investigate previously developed theories on trust in relation to vocal pitch, fWHR, and sentence content in a multimodal setting. Twenty-six female participants were asked to judge the trustworthiness of a voice speaking a neutral or romantic sentence while seeing a face. The average pitch of the voice and the fWHR were varied systematically. Results indicate that the content of the spoken message was an important predictor of trustworthiness extending into multimodality. Further, the mean pitch of the voice and fWHR of the face appeared to be useful indicators in a multimodal setting. These effects interacted with one another across modalities. The data demonstrate that trust in the voice is shaped by task-irrelevant visual stimuli. Future research is encouraged to clarify whether these findings remain consistent across genders, age groups, and languages.
Military Study Abroad as Thailand’s Foreign Policy Between the 1930s–1940s
Authors: Boontanondha Thep 
Published: April 2024

Abstract
The need to modernize the armed forces motivated the Thai government to send a large number of soldiers to Europe to learn military during the absolute monarchy. Sending soldiers to study abroad, on the other hand, had become a part of national diplomacy seeking to balance power between the powerhouse states. After the Revolution of 1932, the new government likewise made an effort to preserve its stability by dismissing many royalist soldiers. As a result, it demanded many sophisticated soldiers, who relied on the new government. Hence, many soldiers had dispatched to observe and study military tactics abroad. On the one hand, the anti-imperialist policy forced the Thai government to favore the Japanese Empire and to rely on its support; many Thai cadets and soldiers were sent to study in Japan. On the other hand, the Japanese diplomacy, Pan-Asianism, made it very evident that Japan demanded to expand its influence over Asia, including Thailand. So, the Thai government seeking to achive a balance of power among the influences of strong countries decided to send numerous soldiers, including the sons of Phibunsongkhram, to study military tactics in Europe and the United States. This pursuit of a balance of power received a positive response from European nations and the US, who were also concerned about Japan’s influence over their colonies in Asia. Unfortunately, the outbreak of the Second World War shattered Thailand’s hopes of attaining a balance of power among the powerful countries.
Relationship between social inequality perception patterns and depressive symptoms among Chinese adults: A national representative longitudinal study
Authors: Zhang Shouchuang , Wang Ting , Zhang Lanyue , Wei Yuehui , Jian Weiyan , Guo Jing 
Published: April 2024

Background: The rising prevalence of depressive symptoms presents a pressing global public health concern, exacerbated by prevailing social inequality. Aim: This study seeks to identify latent profiles of social inequality perception and explore their associations with depressive symptoms. Methods: Data were obtained from the China Family Panel Studies (CFPS) involving 10,529 residents aged 18 years and above. Latent profile analysis (LPA) was used to identify different patterns of social inequality perception. Multiple linear regression analysis examined the links between these patterns and depressive symptoms. Results: Three distinct patterns of social inequality perception were identified: the disappointed pattern (TDP), the neutral pattern (TNP), and the positive pattern (TPP). Perceived social inequality was significantly associated with short-term and long-term depressive symptoms (β = .51, 95% CI [0.29, 0.72] vs. β = .51, 95% CI [0.27, 0.74]). Increases in social inequality perception patterns were also related to more severe depressive symptoms (β = .55, 95% CI [0.36, 0.74]). Conclusions: Increasing perceived social inequality is closely linked to elevated depressive symptoms in Chinese adults. This underscores the need for tailored strategies aimed at addressing heightened perceptions of social inequality to reduce the risk of depressive symptoms.
Experiences of Parenting an Autistic Individual During Adolescence and Emerging Adulthood in the Indian Context: An Interpretative Phenomenological Analysis
Authors: Manohar Harshini , Kommu John Vijay Sagar , Kishore M. Thomas , Jacob Preeti , Jayarajan Deepak 
Published: April 2024

Background and aims: The needs of autistic individuals and their families are unique in each developmental phase, but this diversity is more palpable during adolescence. Literature generally presents a view that caregivers experience challenges in caring for autistic children, especially in low- and middle-income countries, where formal support services are uneven or unavailable. The present study explored the lived experiences of parents of autistic adolescents in the Indian context. Methods: In-depth interviews with 12 parents were analyzed using an interpretative phenomenological approach. Results: Three superordinate themes were derived: (a) Acceptance alongside recurring experiences of grief and loss, (b) post-traumatic growth and vicarious transformation, and (c) What after me? Planning for future care services with limited systemic support. Beginning with the initial recognition and diagnosis of autism spectrum disorder, parents progressed through a series of experiences that strengthened and challenged their understanding and aided in their acceptance. Parents recognize their adolescents’ key attributes, growth, development, and persisting differences that could contribute to future challenges. Grief experiences, however, sporadic, persisted alongside acceptance. Conclusion: Despite challenges, families were adapting to the changing needs of the developmental phases in unique ways, with or without formal support available to them. Nonetheless, there is a considerable need to address the existing gaps and felt needs of parents, focusing on empowering parents and capacity building toward providing comprehensive services to autistic individuals with a lifespan approach.
On the fatigue behaviour of epoxy-based nanostructured composite materials
Authors: Garofalo Salvatore , Rovale Gerardo , Morano Chiara , Furgiuele Franco , Minervino Matteo , Pagnotta Leonardo 
Published: April 2024

Epoxy composites and nanocomposites enable the creation of high-performance structures and innovative designs. However, there is limited research focused on their fatigue characterization. The purpose of this study is to analyze the fatigue resistance results of nanostructured composite materials made with an epoxy matrix of Diglycidyl Ether of Bisphenol F and 9,9-bis(3-chloro-4-aminophenyl) fluorine (DGEBF-CAF) reinforced with 5%wt of elastomeric nanoparticles with an average diameter of 200 nm. The tests are conducted at variable load and frequency using Rotating Bending (R-B) and Tensile-Tensile (T-T) tests, and the results are compared to those obtained with pure resin. The occurrence of thermal fatigue phenomena during the tests is monitored using a thermal camera. The results confirm that pure epoxy resin exhibits poor crack propagation resistance due to its low ductility and toughness, and the introduction of a second phase leads to an improvement of approximately 3 times in T-T tests and 5 times in R-B tests.
Experimental analysis of mechanical properties of e-waste composite materials with dual glass fibers
Authors: Raja Thirunavukkarasu , Ayyakkannu Vadivel , Rathinasamy Tamilselvan 
Published: April 2024

This study aimed to evaluate the mechanical characteristics and application of e-waste as a filler for glass fiber composites made of S and E (e-waste + S E). Metal, printed circuit boards, integrated circuits, diodes, and transistors were separated from the e-waste filler during milling. S and E glass fiber, epoxy, and filler were utilized in proportions of 10%, 10%, and 70%, respectively, on a volume basis. The hand lay-up technique was used to construct composite specimens. Scanning electron microscope analysis was used to gauge how filler loading affected the morphology of composite materials. The composite has a compressive strength of 23.760 MPa, which is 69.71% higher than the Geo poly composite. The tensile strength of this composite is withstood up to 16.078 MPa. It has 53% better tensile properties than Sunflower Husk composites with the same operating conditions. It gives a resistance up to 42 D during hardness test to withstand. It was 15.6% better than the NF30% epoxy composite specimen. The e-waste + S E composite gives a great opposite force of up to 2 kJ on the impact load test.; it was 86.9% higher than fly ash epoxy composites.
What Are the Real Issues in Providing Extracorporeal Membrane Oxygenation (ECMO) Support: A Survey
Authors: Siddiqui Shahla , Arora Lovkesh , Lupei Monica I. , Satyapriya S. Veena , Wall Michael , Cobas Miguel , Justice Samuel , Bartz Raquel R. 
Published: April 2024

Introduction By using a novel survey our study aimed to assess the challenges ECMO and Critical Care (CC) teams face when initiating and managing patient's ECMO support. Methods A qualitative survey-based observational study was performed of members of 2 Critical Care Medicine organizations involved in decision-making around the practice of Extracorporeal Membrane Oxygenation (ECMO). The range of exploratory questions covered ethical principles of informed consent, autonomy and goals of care discussions, beneficence, non-maleficence (offering life-sustaining treatments in end-of-life care), and justice (insurance-related limitations of treatment). Questions also covered pragmatic practice and quality improvement areas, such as exploring whether palliative care or ethics teams were involved in such decision-making. Results 305 members received the survey links, and a total of 61 completed surveys were received, for an overall response rate of 20% among all eligible members. Only 70% of the participants who manage ECMO patients are involved in the ECMO initiation decision process. The majority do not involve Ethics or Palliative care at the initial ECMO initiation decision step. Of the ethical and moral dilemmas reported, the majority revolved around 1. Prognostication of patients receiving VV and VA ECMO support, 2. Lack of knowledge of patient's wishes and goals, 3. Disconnect between expectations of families and outcomes and 4. Staff moral distress around when to stop ECMO in case of futility. Conclusion Our survey highlights areas of distress and dilemma which have been stressed before in the initiation, management, and outcomes of ECMO patients, however with the increasing use of this modality of cardiopulmonary mechanical support being offered, the survey results can offer a guidance using sound ethical principles.
Favorable osteogenic activity of vericiguat doped in β-tricalcium phosphate: In vitro and in vivo studies
Authors: Tao Zhou-Shan , Shen Cai-Liang 
Published: April 2024

Recently, more and more studies have shown that guanylate cyclase, an enzyme that synthesizes cyclic guanosine monophosphate (cGMP), plays an important role in bone metabolism. Vericiguat (VIT), a novel oral soluble guanylate cyclase stimulator, directly generates cyclic guanosine monophosphate and reduce the death incidence from cardio-vascular causes or hospitalization. Recent studies have shown beneficial effects of VIT in animal models of osteoporosis, but very little is currently known about the effects of VIT on bone defects in the osteoporotic states. Therefore, in this study, β-tricalcium phosphate (β-TCP) was used as a carrier to explore the effect of local VIT administration on the repair of femoral metaphyseal bone defects in ovariectomized (OVX) rats. When MC3T3-E1 was cultured in the presence of H2H2, VIT, similar to Melatonin (MT), therapy could increase the matrix mineralization and ALP, SOD2, SIRT1, and OPG expression, reduce ROS and Mito SOX production, RANKL expression, Promote the recovery of mitochondrial membrane potential. In the OVX rat model, VIT increases the osteogenic effect of β-TCP and better results were obtained at a dose of 5 mg. Local use of VIT can inhibit increased OC, BMP2 and RUNX2 expressions in bone tissue, while decreased SOST and TRAP expressions by RT-PCR and immunohistochemistry. Thereby, VIT stimulates bone regeneration and is a promising candidate for promoting bone repair in osteoporosis.
Return to Sports Activity After Microfracture for Osteochondral Lesion of the Talus in Skeletally Immature Children
Authors: Tomonaga Seiya , Yoshimura Ichiro , Hagio Tomonobu , Ishimatsu Tetsuro , Sugino Yuki , Fukagawa Ryo , Taniguchi Yoshimasa , Yamamoto Takuaki 
Published: April 2024

Background: Osteochondral lesions of the talus (OLTs) are among the common sports-related injuries. However, there are few reports on the return to sports after OLT surgery in skeletally immature children. This study was performed to evaluate the return to sports after microfracture for OLTs in skeletally immature children. Methods: This study involved 17 ankles of 16 patients (mean age, 13.2 years; range, 10-16 years) with open tibial epiphyses on magnetic resonance imaging (MRI) who underwent microfracture for OLTs <10 mm in diameter and confirmation of lesion instability under arthroscopy. Nine of 17 ankles had additional lateral ankle ligament stabilization. All patients were participating in some form of sports. The Japanese Society for Surgery of the Foot (JSSF) score, Ankle Activity Score (AAS), return to sports rate, lesion size, grade of subchondral bone marrow edema, and Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score on MRI were evaluated after microfracture. The mean postoperative follow-up period was 53.5 months. Results: The mean JSSF score significantly improved from 76.1 points preoperatively to 94.9 points at the final follow-up ( P < .01). The mean AAS showed no change from preoperative state to final follow-up. The return to sports rate was 100%. The lesion size significantly decreased from 76.3 to 56.7 mm2 in area ( P = .02) and from 283.2 to 185.6 mm3 in volume ( P = .05). The bone marrow edema grade decreased in 8 of 17 ankles. The total MOCART score showed a significant improvement from 6 months to 1 year postoperatively ( P = .05). Conclusion: All skeletally immature children who underwent microfracture for OLTs in this study were able to return to sports activity and showed improvements in clinical scores and MRI parameters. Microfracture may be considered an effective first-line treatment for OLTs <10 mm in diameter in skeletally immature athletes. Level of Evidence: Level IV, retrospective case-control study.