bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Follow-up of Patients With Autonomous Thyroid Nodules Treated With Radioiodine
Authors: Moroto Débora , Torquato-Vieira Isabel C. O. , Fiorin Lia B. , Camacho Cléber P. , Castiglioni Mário Luiz V. , Maciel Rui M. B. , Furlanetto Reinaldo P. , Matsumura Luiza K. , Janovsky Carolina C. P. S. , Lindsey Susan C. , Martins João Roberto M. 
Published: April 2024

Purpose
This article aims to describe the presentation of Plummer disease and its evolution after radioiodine treatment and determine factors that may influence treatment efficacy.

Patients and Methods
The sample included retrospective medical records of 165 adult patients with toxic nodular goiter treated with radioiodine between 1997 and 2017, followed up at a single thyroid center.

Results
The efficacy of treatment with a single dose of radioiodine was higher than 90%. The mean radioiodine activity was 28.9 ± 3.4 mCi. The mean time between radioiodine performance and hyperthyroidism resolution was 3.6 ± 3.0 months, ranging from 1–12 months. After the first year, 33.9% of the patients were under hypothyroidism, 59.4% under euthyroidism, and 6.7% under hyperthyroidism. Among the nonresponders, the variables that showed statistical difference were the presence of multinodular goiter and the radioiodine activity (mean, 25.5 ± 6.5 mCi; median, 30 [15–30 mCi]). The cumulative rate of hypothyroidism was 48.9% over 20 years of follow-up.

Conclusions
Radioiodine therapy is an effective and safe treatment. In Plummer disease, high rates of euthyroidism are expected after the radioiodine treatment. Therapeutic failure was observed mainly in patients with larger multinodular goiters treated with lower doses of radioiodine. The evolution to hypothyroidism was mostly observed in younger patients with larger and uninodular goiters.
Certification Training and Liver Transplant Experience Improves Liver Procurement Outcomes: The Dutch Approach
Authors: Lam Hwai-Ding , Ploeg Rutger , Nijboer Willemijn N. , Alwayn Ian P.J. , Coenraad Minneke , Hemke Aline C. , Bastiaannet Esther , Putter Hein , Baranski Andrzej 
Published: April 2024

Background.
This study investigates the impact of certification training and liver transplant experience on procurement outcomes of deceased donor liver procurement in the Netherlands.

Methods.
Three groups (trainee, certified, and master) were formed, with further subdivision based on liver transplant experience. Three key outcomes—surgical injury, graft discard after injury, and donor hepatectomy duration—were analyzed.

Results.
There were no significant differences in surgical graft injury in the three groups (trainee, 16.9%; certified, 14.8%; master, 18.2%; P = 0.357; 2011 to 2018). The only predictor for surgical graft injury was donation after circulatory death (odds ratio [OR], 1.49; 95% confidence interval [CI], 1.10-2.02). Of the three groups, the master group had the highest discard rate after surgical injury (trainee, 0%; certified, 1.3%; master, 2.8%; P = 0.013). Master group without liver transplant experience (OR, 3.16; 95% CI, 1.21-8.27) and male donor sex (OR, 3.58; 95% CI, 1.32-9.73) were independent risk factors for discarding livers after surgical injury. Independent predictors for shorter hepatectomy durations included donors older than 50 years (coefficient [Coeff], −7.04; 95% CI, −8.03 to −3.29; P < 0.001), and master group (Coeff, −9.84; 95% CI, −14.37 to −5.31; P < 0.001) and certified group with liver transplant experience (Coeff, −6.54; 95% CI, −10.83 to −2.26; P = 0.003). On the other hand, master group without liver transplant experience (Coeff, 5.00; 95% CI, 1.03-8.96; P = 0.014) and donation after circulatory death (Coeff, 10.81; 95% CI, 8.32-13.3; P < 0.001) were associated with longer hepatectomy durations.

Conclusions.
Training and certification in abdominal organ procurement surgery were associated with a reduced discard rate for surgical injured livers and shorter hepatectomy times. The contrast between master group with and without liver transplant experience underscores the need for specialized training in this field.
Bangladesh should engage the private sector for malaria elimination by 2030
Authors: McArdle Ryan Patrick , Phru Ching Swe , Hossain Mohammad Sharif , Alam Mohammad Shafiul , Haldar Kasturi 
Published: April 2024

ABSTRACTBangladesh reduced malaria by 93% from 2008-2020 through the action of governmental and non-governmental organizations, yet ∼18 million people continue to live at risk of infection. For-profit private healthcare providers, catalytic for malaria elimination in many countries, have not yet been integrated into the national program. By imposing strict definitions on a large and complex literature surrounding private healthcare sector engagement, we distilled eight distinct strategies important in other developing settings: contracting, financing, subsidization, regulation, social franchising, demand-side interventions, infrastructure-building and training. We weighed these in the context of Bangladesh’s flourishing private health care sector—driven by patient demand, self-interest, and aspirations for public good—as well as the heterogeneity in provider capacity and malaria prevalence across districts. We developed a new model dependent on five strategies of subsidization, training, infrastructure building, demand-side intervention, and referral financing, to empower Bangladesh’s phased agenda of eliminating indigenous malaria transmission by 2030.
The application of deep learning in lung cancerous lesion detection
Authors: Chu Phuong Thi Minh , Ha Tram Pham Bich , Vu Ngoc Minh , Ha Hoang , Doan Thu Minh 
Published: April 2024

AbstractBackgroundCharacterized by rapid metastasis and a significant death rate, lung cancer presents a formidable challenge, which underscores the critical role of early detection in combating the disease. This study addresses the urgent need for early lung cancer detection using deep learning models applied to computed tomography (CT) images.MethodsOur study introduced a unique non-cancer pneumonia dataset, a publicly available large-scale collection of high-quality pneumonia CT scans with detailed descriptions. We utilized this dataset to fine-tune nine pretrained models, including DenseNet121, MobileNetV2, InceptionV3, InceptionResNetV2, ResNet50, ResNet101, VGG16, VGG19, and Xception for the classification of lung cancer and pneumonia.ResultsResNet50 demonstrated the highest accuracy and sensitivity (97.7% and 100%, respectively), while InceptionV3 excelled in precision (97.9%) and specificity (98.0%). The study also highlighted the contribution of the gradient-weighted class activation mapping (Grad-CAM) technique in examining the effectiveness of the model-training process via the visualization of features learned across different layers. Grad-CAM revealed that among the best-performed models, InceptionV3 successfully identified cancerous lesions in CT scans. Our findings demonstrated the potential of deep learning models in early lung cancer screening and improving the accuracy of the diagnosis procedure.Data availabilityThe pneumonia CT scan dataset used in this study is extracted from peer-reviewed publications and can be accessed athttps://github.com/ReiCHU31/CT-pneumonia-dataset
WHIRLY1 regulates aliphatic glucosinolate biosynthesis in early seedling development of Arabidopsis
Authors: Nguyen Linh Thuy , Moutesidi Pinelopi , Ziegler Jörg , Glasneck Anike , Khosravi Solmaz , Abel Steffen , Hensel Götz , Krupinska Karin , Humbeck Klaus 
Published: April 2024

AbstractWHIRLY1 belongs to a family of plant-specific transcription factors capable of binding DNA or RNA in all three plant cell compartments that contain genetic materials. InArabidopsis thaliana, WHIRLY1 has been studied at the later stages of plant development, including flowering and leaf senescence, as well as in biotic and abiotic stress responses. In this study,WHIRLY1knock-out mutants ofA. thalianawere prepared by CRISPR/Cas9 to investigate the role of AtWHIRLY1 during early seedling development. The loss-of-function ofWHIRLY1in 5-day-old seedlings did not cause differences in the phenotype and the photosynthetic performance of the emerging cotyledons compared to the wild type. Nevertheless, comparative RNA sequencing analysis revealed that the knock-out ofWHIRLY1affected the expression of a small but specific set of genes during this critical phase of development. About 110 genes were found to be significantly deregulated in the knockout mutant, wherein several genes involved in the early steps of aliphatic glucosinolate (aGSL) biosynthesis were suppressed compared to wild type plants. The downregulation of these genes inWHIRLY1knock-out line led to a decreased GSL contents in seedlings and in seeds. We also examined myrosinase activity during seed-seedling transition and showed that the reduction in aGSL biosynthesis is the main reason for lowering aGSL content in young seedlings. The results suggest that AtWHIRLY1 plays a role in regulating aliphatic glucosinolate biosynthesis during early seedling development.Significance statementWHIRLY1 functions in several aspects of plant development and stress responses, however little is known about its involvement in young seedling development. Here we show that in this stage, WHIRLY1 specifically regulates expression of genes encoding enzymes in the early steps of aliphatic glucosinolate biosynthesis pathway, leading to a reduction in glucosinolate content in theWHIRLY1knock-out seedlings.
The development of the gynecologic oncology pathway “VivaPathway GT“ – a qualitative study about the transformation from an implicit to an explicit, evidence-based clinical pathway in a Berlin-based tertiary care hospital
Authors: Büscher Anne , Reinhold Nicolle , Kugler Joachim 
Published: April 2024

AbstractIntroductionStandardization in healthcare is crucial for comprehensive patient care, as emphasized by the WHO and quality management principles. Clinical pathways offer a structured approach to describing essential processes, particularly relevant in gynecologic oncology care. Despite their proven benefits, pathways remain underutilized, highlighting the need for explicit translation of implicit pathways.Materials and MethodsThis study employed semi-structured interviews with healthcare professionals to capture implicit gynecologic oncology pathway. Interviews were examined using qualitative content analysis. External requirements, legal mandates, and certification criteria were integrated into pathway development. A participatory approach involving interprofessional collaboration guided pathway refinement.ResultsThe study applied the Pathway Association’s 7-phase method, illustrating the development of VivaPathway GT. The explicit pathway, enriched with external requirements, comprised 26 steps, enhancing comprehensiveness and interprofessional involvement. Notable additions included pre-therapeutic tumor boards and detailed post-operative consultations.DiscussionTransitioning from implicit to explicit pathways is a is a demanding and challenging process emphasizing stakeholder engagement and IT support. Financial constraints pose challenges, but initiatives like quality contracts offer opportunities for resource allocation. The study validates hypotheses, confirming the efficacy of collaboration of involved professionals and integration of external requirements in pathway development.ConclusionsThis study underscores the importance of explicit clinical pathways. It provides valuable insights for healthcare professionals facing similar challenges, emphasizing the need for ongoing evaluation and adaptation. Despite resource challenges, stakeholder collaboration and IT support are crucial for pathway effectiveness and relevance in evolving healthcare landscapes.
Upper respiratory microbial communities of healthy populations are shaped by niche and age
Authors: Zelasko Susan , Swaney Mary Hannah , Sandstrom Shelby , Davenport Timothy C. , Seroogy Christine M. , Gern James E. , Kalan Lindsay R. , Currie Cameron R. 
Published: April 2024

AbstractBackgroundAlterations in upper respiratory microbiomes have been implicated in shaping host health trajectories, including by limiting mucosal pathogen colonization. However, limited comparative studies of respiratory microbiome development and functioning across age groups have been performed. Herein, we perform shotgun metagenomic sequencing paired with pathogen inhibition assays to elucidate differences in nasal and oral microbiome composition and functioning across healthy 24-month-old infant (n=229) and adult (n=100) populations.ResultsWe find that beta diversity of nasal and oral microbiomes varies with age, with nasal microbiomes showing greater population-level variation compared to oral microbiomes. Infant microbiome alpha diversity was significantly lower across nasal samples and higher in oral samples, relative to adults. Accordingly, we demonstrate significant differences in genus- and species-level composition of microbiomes between sites and age groups. Antimicrobial resistome patterns likewise varied across body sites, with oral microbiomes showing higher resistance gene abundance compared to nasal microbiomes. Biosynthetic gene clusters encoding specialized metabolite production were found in higher abundance across infant oral microbiomes, relative to adults. Investigation of pathogen inhibition revealed greater inhibition of gram-negative and gram-positive bacteria by oral commensals, while nasal isolates had higher antifungal activity.ConclusionsIn summary, we identify significant differences in the microbial communities inhabiting nasal and oral cavities of healthy infants relative to adults. These findings inform our understanding of the interactions impacting respiratory microbiome composition and functioning, with important implications for host health across the lifespan.
Wearables and smartphones for modifiable risk factors in metabolic health: a scoping review protocol
Authors: Brügger Victoria , Kowatsch Tobias , Jovanova Mia 
Published: April 2024

AbstractBackgroundMetabolic diseases, such as cardiovascular diseases and diabetes, contribute significantly to global mortality and disability. Wearable devices and smartphones increasingly track physiological and lifestyle risk factors and can improve the management of metabolic diseases. However, the absence of clear guidelines for deriving meaningful signals from these devices often hampers cross-study comparisons.ObjectiveThus, this scoping review protocol aims to systematically overview the current empirical literature on how wearables and smartphones are used to measure modifiable risk factors associated with metabolic diseases.MethodsWe will conduct a scoping review to overview how wearables and smartphones measure modifiable risk factors related to metabolic diseases. We will search six databases (Scopus, Web of Science, ScienceDirect, PubMed, ACM Digital Library, and IEEE Xplore) from 2019 to 2024, with search terms related to wearables, smartphones, and modifiable risk factors associated with metabolic diseases. We will apply the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) and Arksey and O’Malley’s scoping review methodology. Eligible studies will use smartphones and/or wearables (worn on the wrist, finger, arm, hip, and chest) to track physiological and/or lifestyle factors related to metabolic diseases. Two reviewers will independently screen articles for inclusion. Data will be extracted using a standardized form, and the findings will be synthesized and reported qualitatively and quantitatively.ResultsThe study is expected to identify potential gaps in measuring modifiable risk factors in current digital metabolic health research. Results are expected to inform more standardized guidelines on wearable and smartphone-based measurements to aid cross-study comparison. The final report is planned for submission to an indexed journal.ConclusionsThis review is among the first to systematically overview the current landscape on how wearables and smartphones are used to measure modifiable risk factors associated with metabolic diseases.
When do customers become your trusted allies: Unveiling pathways for enhanced citizenship in family-owned hotels
Authors: Habib Syed Muhammad Ali Shahbaz , Sindhu Mahwish , Saleem Irfan 
Published: April 2024

PurposeDrawing upon social exchange theory, this research investigates the interplay of corporate philanthropy, environmental marketing strategy, relationship quality, greenwashing, and customer citizenship behavior in the family-owned hotels of an emerging market.Design/methodology/approachA field survey questionnaire was used to gather the data from 394 hotel customers by randomly selecting three premium family-owned hotels in Lahore: Faletti’s, Avari, and Holiday Inn. The data was analyzed using the structural regression modeling (SRM) technique with the assistance of AMOS version 24.FindingsThe results show that corporate philanthropy and environmental marketing strategy positively influence relationship quality, and relationship quality positively influences customer citizenship behavior. Relationship quality partially mediates the association between corporate philanthropy and customer citizenship behavior, but we found that greenwashing does not have a moderating role.Research limitations/implicationsThis research has theoretical implications for marketing scholars and practical implications of family-owned hotels in emerging markets.Originality/valueThe study has contributed contextually by collecting a unique dataset from family-owned hotels in an emerging market. Theoretically, we have conceptualized a model through the Social Exchange Theory by recommending relationship quality as a mediator and greenwashing as a moderator.
Give me a human! How anthropomorphism and robot gender affect trust in financial robo-advisory services
Authors: Plotkina Daria , Orkut Hava , Karageyim Meral Ahu 
Published: April 2024

PurposeFinancial services industry is increasingly showing interest in automated financial advisors, or robo-advisors, with the aim of democratizing access to financial advice and stimulating investment behavior among populations that were previously less active and less served. However, the extent to which consumers trust this technology influences the adoption of rob-advisors. The resemblance to a human, or anthropomorphism, can provide a sense of social presence and increase trust.Design/methodology/approachIn this paper, we conduct an experiment (N = 223) to test the effect of anthropomorphism (low vs medium vs high) and gender (male vs female) of the robo-advisor on social presence. This perception, in turn, enables consumers to evaluate personality characteristics of the robo-advisor, such as competence, warmth, and persuasiveness, all of which are related to trust in the robo-advisor. We separately conduct an experimental study (N = 206) testing the effect of gender neutrality on consumer responses to robo-advisory anthropomorphism.FindingsOur results show that consumers prefer human-alike robo-advisors over machinelike or humanoid robo-advisors. This preference is only observed for male robo-advisors and is explained by perceived competence and perceived persuasiveness. Furthermore, highlighting gender neutrality undermines the positive effect of robo-advisor anthropomorphism on trust.Originality/valueWe contribute to the body of knowledge on robo-advisor design by showing the effect of robot’s anthropomorphism and gender on consumer perceptions and trust. Consequently, we offer insightful recommendations to promote the adoption of robo-advisory services in the financial sector.
Do total quality management and external factors matter? The effect of innovation behaviour on innovation performance in banks
Authors: Koomson Samuel 
Published: April 2024

Purpose
Although total quality management (TQM) is an innovative management philosophy, how it connects innovative behaviour (INB) to innovation performance (INP) has gone unnoticed. Also, the external factors (technological turbulence [TUR], competitive intensity [CMP], market dynamism [MKD] and government regulation [GOV]) under which the INB–TQM connection may grow are yet to be understood. In spite of the various evolutions that have occurred in the banking industry, there remains a necessity to enhance the quality of service offered to clients. This paper aims to address these issues in the total quality management literature.

Design/methodology/approach
This study constructs and analyses a research framework by analysing the replies of 260 executives in senior and intermediate positions across 21 quality-certified universal banks in Ghana, using the Smart PLS methodology.

Findings
TQM played a partial mediating role between INB and INP (variance accounted for = 46.85%, p = 0.000). TUR (β = 0.023, p = 0.000), CMP (β = 0.043, p = 0.000), MKD (β = 0.056, p = 0.000) and GOV (β = 0.068, p = 0.000) positively and significantly moderated the INB–TQM connection.

Research limitations/implications
Future research may examine the proposed framework in various environments and sectors.

Practical implications
Practical insights for industry players in the sector are discussed.

Originality/value
To the best of the authors’ knowledge, this study is the first to show how innovation serves both as an antecedent and consequence of TQM. It is also the first to explicate the boundary conditions under which the INB–TQM relationship may flourish.
Anticipated chilly climate for women: the development and validation of a measure
Authors: Puncheva-Michelotti Petya , Hudson Sarah , Hennekam Sophie 
Published: April 2024

PurposeThis study develops a measure of anticipated chilly climate for women and provides initial evidence of its validity.Design/methodology/approachWe draw on three studies. Study 1 consisted of three focus groups to gain deeper insights into the meaning of the concept for prospective female jobseekers and generate scale items. In Study 2, we pre-tested job post vignettes (N = 203), refined the scale items and explored the factor structure (N = 136). Study 3 aimed to determine the convergent and discriminant validity of the new scale (N = 224) by testing its relationships with organisational attractiveness, person-organisation fit perceptions and gendered language.FindingsThe results show that the anticipated chilly climate is an important concept with implications for applicants’ career decision-making and career growth in the technology industry, where women tend to be underrepresented. Perceptions of anticipated chilly climate comprise expectations of devaluation, marginalisation and exclusion from the prospective employment. The masculine stereotypes embedded in the language of the job posts signalled a chilly climate for both genders, negatively affecting perceptions of fit and organisational attractiveness.Originality/valueMost previous studies have focussed on the actual experiences of chilly climates in organisations. We extend this body of literature to anticipatory climates and draw on social identity threat theory and signalling theory to highlight that job applicants make inferences about the climate they expect to find based on job ads. Specifically, they may anticipate a chilly climate based on cues from job ads signalling masculine stereotypes. Whilst the literature has emphasised women’s perceptions of chilly climates within organisations, our results show that both genders anticipate chilly climates with detrimental consequences for both organisations and prospective job applications.