bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping Motor Preparation in the Developing Brain: Insights from Contingent Negative Variation and Event-related Mu Rhythm Modulation
Authors: Schmidgen Julia , Heinen Theresa , Konrad Kerstin , Bender Stephan 
Published: March 2024

AbstractIntroductionThe motor system shows a pronounced development throughout childhood and adolescence. The analysis of the contingent negative variation (CNV) provides valuable insights into various cognitive and motor processes, underlying cortical sources, and their development across the lifespan.MethodsWe investigated the maturation of motor preparation, pre-activation and post-processing in children and adolescents aged 5- to 16- years. EEG Data of 46 healthy right-handed subjects were recorded, using a 64-electrode high density sensor array. Subjects performed a CNV task with a directional warning cue. To assess age related developmental differences of cortical activation, analyses of event-related potentials (ERPs), mu-rhythm (de)synchronization and source analysis were applied.ResultsChildren showed increased reaction times and committed more errors than adolescent subjects. Motor preparation and post-processing were characterized by a developmental increase of cortical activity related to the supplementary motor area (SMA). Young children showed a pronounced sensory post processing during orienting response (early CNV) that decreased with age. In contrast to previous research in young adults, adolescent subjects showed no contralateral activation of motor areas during motor preparation (late CNV) yet. Furthermore, there was an observed decline in motor post processing with maturation.ConclusionThe results indicate a prolonged maturation of cortical scalp areas associated with motor control up into late adolescence or early adulthood. With age, the activation of mid-frontocentral regions associated with the SMA becomes more pronounced during motor planning and response evaluation. Qualitatively distinct cortical activation patterns of young subjects suggest immature supplementary-, pre- and primary motor areas and might be a primary cause for age-related increasing efficiency of motor action control.
Stable germline transgenesis using theMinosTc1/marinerelement in the sea urchin,Lytechinus pictus
Authors: Jackson Elliot W. , Romero Emilio , Kling Svenja , Lee Yoon , Tjeerdema Evan , Hamdoun Amro 
Published: March 2024

AbstractStable transgenesis is a transformative tool in model organism biology. While the sea urchin is one of the oldest animal models in cell and developmental biology, it has relied on transient manipulations of wild animals, and has lacked a strategy for stable transgenesis. Here we build on recent progress to develop a more genetically tractable sea urchin species,Lytechinus pictus, to establish a robust transgene integration method. Three commonly used transposons (Minos, Tol2, piggyBac) were tested for non-autonomous transposition, using plasmids containing a polyubiquitin promoter upstream of a H2B-mCerulean nuclear marker.Minoswas the only transposable element that resulted in significant expression past metamorphosis. F0animals were raised to sexual maturity and spawned to determine germline integration, transgene inheritance frequency, and to characterize expression patterns of the transgene in F1progeny. The results demonstrated transgene transmission through the germline, the first example of a germline transgenic sea urchin, and indeed of any echinoderm. This milestone paves the way for the generation of diverse transgenic resources that will dramatically enhance the utility, reproducibility, and efficiency of sea urchin research.Significance StatementTransgenic tools are essential for effective utilization of animal models. Despite being an established model for cell and developmental biology, the sea urchin has not previously benefited from transgenic technology. This study reports the generation of the first germline transgenic sea urchin and opens new avenues for this organism.
Panax ginseng enhances the effect of metoprolol in chronic heart failure by inhibiting autophagy
Authors: Zichang Niu , Xiaoling Han , Ting Liu , Qi Jin , Minghui Ouyang , Haoping Mao 
Published: March 2024

AbstractContextPanax ginseng is often used as an adjuvant therapy for heart failure (HF) patients. Metoprolol is widely used in patients with HF. However, there is currently no report on the combined effects of ginseng and metoprolol in patients with HF.ObjectiveThe objective of this study is to investigate the combined effects of ginseng and metoprolol in patients with HF and the exact mechanisms.Materials and methodsA mouse myocardial HF model was used. The serum levels of CK and CK-MB were determined using an automated biochemical analyzer. LDH and cTnT levels were determined using enzyme-linked immunosorbent assays. Autophagy of myocardial cells was evaluated using transmission electron microscopy, and changes in signal pathway proteins related to autophagy were analyzed using Western blot.ResultsThe combination of ginseng and metoprolol can increase the survival rate of HF mice, improve heart function, reduce heart damage, and reduce serum CK, CK-MB, LDH, and cTnT levels. The combination of ginseng and metoprolol reduces autophagy in myocardial cells, reduces the levels of autophagy-related proteins (LC3, p62, Beclin1, and Atg5), and increases the p-PI3K/PI3K, p-Akt/Akt, and p-mTOR/mTOR ratios.Discussion and conclusionGinseng enhances the anti-HF effect of metoprolol. Its mechanism of action may be related to inhibition of autophagy mediated by the PI3K/Akt/mTOR pathway.
Role of Y box-binding protein 1 (Ybx1/ybx1) in zebrafish folliculogenesis: Promoting follicle cell proliferation via suppression of cell cycle inhibitor p21 (cdkn1a)
Authors: Zhu Bo , Zhang Zhiwei , Pardeshi Lakhansing , Chen Yingying , Ge Wei 
Published: March 2024

AbstractY box-binding protein 1 (YB-1; Ybx1/ybx1) regulates transcription and translation of targeted genes through DNA/RNA-binding. Our research in zebrafish has revealed a high abundance of Ybx1 in the primary growth (PG) follicles in the ovary, which decreases precipitously as the follicles enter the secondary growth (SG) phase. To understand the function of Ybx1 in folliculogenesis, we created anybx1mutant using TALEN and observed a disruption in folliculogenesis in the mutant (ybx1-/-) during the transition from previtellogenic (PV) to early vitellogenic (EV) stage of the SG phase, resulting in underdeveloped ovaries and reduced female fertility. Transcriptome and Western blot analyses identified several differentially expressed genes between mutant (ybx1-/-) and control (ybx1+/-) ovaries. Notably, the expression ofcdkn1a(p21), a cell cycle inhibitor, increased dramatically inybx1-/- follicles. Disruptingcdkn1agene with CRISPR/Cas9 resulted in embryonic lethality. In p21 heterozygote (cdkn1a+/-), however, follicle activation and maturation in the ovary were both advanced, contrasting with theybx1-/-mutant. Interestingly, partial loss of p21 could alleviate the phenotype ofybx1-/-. Folliculogenesis resumed inybx1-/-;p21+/- females with normal follicle activation (PG-PV transition) and vitellogenic growth (PV-EV transition). Interestingly, the follicle cells from theybx1-/- mutant displayed a poor proliferative activity both in vivo and in vitro; however, the cells from theybx1-/-;p21+/- follicles resumed normal proliferation. In conclusion, our study suggests that Ybx1 serves a pivotal role in controlling early folliculogenesis in zebrafish, and its acts, at least partly, by repressing the expression ofcdkn1a,a cell cycle inhibitor.
RIPK1 Biallelic Activating Variants lead to Autoinflammatory Disease Driven by T cell Death
Authors: Dai Jialin , Jin Taijie , Su Gaixiu , Han Xu , Wang Jun , Liu Chenlu , Zheng Wenjie , Zhang Qiuye , Yang Jun , Guo Li , Zhang Dan , Li Ming , Xu Yingjie , Yue Tong , Wen Min , Zhu Jia , Kang Min , Lai Jianming , Wu Feifei , Wang Shihao , Zhang Jiahui , Lee Pui Y. , Yuan Junying , Yu Xiaomin , Zhou Qing 
Published: March 2024

AbstractReceptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key regulator of cell fate decision between pro-survival signaling and programmed cell death. The activation of RIPK1 is extensively modulated by posttranslational modification, such as ubiquitination. RIPK1 overactivation mediates autoinflammatory diseases in humans. However, the role of RIPK1 ubiquitination in human autoinflammatory diseases has not been reported, and the mechanism mediating the interaction of cell death and autoinflammation is largely unknown. Here, we report two patients carrying compound heterozygousRIPK1variants K377E/R390G with recurrent fevers, lymphadenopathy and skin rashes. Mechanistically, K377E and R390G mutations impaired ubiquitination of RIPK1, which suppresses the formation of TNFR1 signaling complex (TNF-RSC) and NF-κB activation, resulting in the loss of CD8+T cells mediated by RIPK1 activation-induced cell death in the patients. We reveal that the death of CD8+T cells promotes the secretion of TNF and IFNγ to activate monocytes and macrophages, which triggers further production of proinflammatory cytokines to amplify autoinflammation. Disruption of the communication between T cells and monocytes/macrophages through pharmacologic blockade of TNF and IFNγ attenuated proinflammatory cytokine production in macrophages. Collectively, our results demonstrate a crucial role of RIPK1 ubiquitination in regulating CD8+T cell death and restraining autoinflammation. Our study demonstrates the mechanism for a group of autoinflammatory diseases mediated by RIPK1 activation-induced cell death, and highlights an important role of CD8+T cells in driving autoinflammation.
Symmetry breaking in an extended O(2) model
Authors: Hostetler Leon , Sakai Ryo , Zhang Jin , Bazavov Alexei , Meurice Yannick 
Published: March 2024

Motivated by attempts to quantum simulate lattice models with continuous Abelian symmetries using discrete approximations, we study an extended-O(2) model in two dimensions that differs from the ordinary O(2) model by the addition of an explicit symmetry breaking term −hqcos(qφ). Its coupling hq allows to smoothly interpolate between the O(2) model (hq=0) and a q-state clock model (hq→∞). In the latter case, a q-state clock model can also be defined for noninteger values of q. Thus, such a limit can also be considered as an analytic continuation of an ordinary q-state clock model to noninteger q. In previous work, we established the phase diagram for noninteger q in the infinite coupling limit (hq→∞). We showed that there is a second-order phase transition at low temperature and a crossover at high temperature. In this work, we seek to establish the phase diagram at finite values of the coupling using Monte Carlo and tensor methods. We show that for noninteger q, the second-order phase transition at low temperature and crossover at high temperature persist to finite coupling. For integer q=2, 3, 4, we know there is a second-order phase transition at infinite coupling (i.e. the well-known clock models). At finite coupling, we find that the critical exponents for q=3, 4 vary with the coupling, and for q=4 the transition may turn into a Berezinskii-Kosterlitz-Thouless transition at small coupling. We comment on the similarities and differences of the phase diagrams with those of quantum simulators of the Abelian-Higgs model based on ladder-shaped arrays of Rydberg atoms.

Published by the American Physical Society
2024
Consumers’ intentions to utilize smartphone diet applications: an integration of the privacy calculus model with self-efficacy, trust and experience
Authors: Mohammed Abdul Alem , Rozsa Zoltan 
Published: March 2024

PurposeThe purpose of this study is to investigate the determinants of behavioral intention to use smartphone diet applications within the emerging market. Specifically, it focuses on the Privacy Calculus Model constructs, encompassing perceived risk and perceived benefit, as well as the pivotal elements of trust and self-efficacy. It also explores the moderating influence of experience on the influencing factors and intention to use a diet application.Design/methodology/approachIn a survey with 572 respondents, data analysis was conducted using partial least squares (PLS) structural equation modeling.FindingsThe findings reveal that perceived risk exerts a significant negative influence on behavioral intention. Conversely, perceived benefit, trust and self-efficacy exhibit a positive impact on behavioral intention. Moreover, the study delves into the moderating role of users' experience, which is found to significantly influence these relationships, suggesting that user experience plays a pivotal role in shaping the adoption dynamics of diet applications.Research limitations/implicationsThe limitations of this study may include the sample size and the specific focus on the emerging market of Saudi Arabia. The implications of the findings are relevant for scholars, developers, marketers, and policymakers seeking to promote the use of smartphone diet applications.Originality/valueThis study adds value by exploring the determinants of behavioral intention in the context of smartphone diet applications, and it is a first attempt to test the moderating role of users' experiences, providing valuable insights for various stakeholders in the field.
Numerical investigation on thermal protection of wind turbine flanges in extremely cold weather
Authors: Zhang Chenyu , Xu Hongtao , Da Yaodong 
Published: March 2024

Purpose
Thermal protection of a flange is critical for preventing tower icing and collapse of wind turbines (WTs) in extremely cold weather. This study aims to develop a novel thermal protection system for the WTs flanges using an electrical heat-tracing element.

Design/methodology/approach
A three-dimensional model and the Poly-Hexacore mesh structure are used, and the fluid-solid coupling method was validated and then deployed to analyze the heat transfer and convection process. Intra-volumetric heat sources are applied to represent the heat generated by the heating element, and the dynamic boundary conditions are considered. The steady temperature and temperature uniformity of the flange are the assessment criteria for the thermal protection performance of the heating element.

Findings
Enlarging the heating area and increasing the heating power improved the flange's temperature and temperature uniformity. A heating power of 4.9 kW was suitable for engineering applications with the lowest temperature nonuniformity. Compared with continuous heating, the increased temperature nonuniformity was buffered, and the electrical power consumption was reduced by half using pulse heating. Pulse heating time intervals of 1, 3 and 4 h were determined for the spring, autumn and winter, respectively.

Originality/value
The originality of this study is to propose a novel electrical heat-tracing thermal protection system for the WTs flanges. The effect of different arrangements, heating powers and heating strategies was studied, by which the theoretical basis is provided for a stable and long-term utilization of the WT flange.
Assessing the acceptance of mobile phone technology in Tanzanian SMEs
Authors: Mushi Renatus Michael 
Published: March 2024

Purpose This study investigates the acceptance of mobile phone technology in Tanzanian small- and medium-sized enterprises (SMEs) using the Technology Acceptance Model (TAM) with a special focus on service quality.Design/methodology/approach The conceptual framework was designed by extending the TAM with an additional construct, service quality, before testing a model in a survey of 155 respondents and analysing using Smart PLS 4.Findings Service quality was found to be among the significant factors in the acceptance of mobile phone technology among SME employees.Research limitations/implications This implies that the higher the quality of service offered, the more employees accept and use mobile phone technology in their duties and improve the productivity of SMEs.Practical implications The aspects of quality of mobile phone technology usage such as call dropouts, network quality, speed, etc., must be improved significantly.Social implications The Mobile Network Operators and Regulators must understand that employees are offered the most accurate and reliable mobile phone services for its usefulness to be realised.Originality/value The originality is a modified version of a TAM that accommodates service quality that has been tested in the Tanzanian context.
Business intelligence and the leverage of information in healthcare organizations from a managerial perspective: a systematic literature review and research agenda
Authors: Trincanato Edoardo , Vagnoni Emidia 
Published: March 2024

PurposeBusiness intelligence (BI) systems and tools are deemed to be a transformative source with the potential to contribute to reshaping the way different healthcare organizations’ (HCOs) services are offered and managed. However, this emerging field of research still appears underdeveloped and fragmented. Hence, this paper aims to reconciling, analyzing and synthesizing different strands of managerial-oriented literature on BI in HCOs and to enhance both theoretical and applied future contributions.Design/methodology/approachA literature-based framework was developed to establish and guide a three-stage state-of-the-art systematic literature review (SLR). The SLR was undertaken adopting a hybrid methodology that combines a bibliometric and a content analysis.FindingsIn total, 34 peer-review articles were included. Results revealed significant heterogeneity in theoretical basis and methodological strategies. Nonetheless, the knowledge structure of this research’s stream seems to be primarily composed of five clusters of interconnected topics: (1) decision-making, relevant capabilities and value creation; (2) user satisfaction and quality; (3) process management, organizational change and financial effectiveness; (4) decision-support information, dashboard and key performance indicators; and (5) performance management and organizational effectiveness.Originality/valueTo the authors’ knowledge, this is the first SLR providing a business and management-related state-of-the-art on the topic. Besides, the paper offers an original framework disentangling future research directions from each emerged cluster into issues pertaining to BI implementation, utilization and impact in HCOs. The paper also discusses the need of future contributions to explore possible integrations of BI with emerging data-driven technologies (e.g. artificial intelligence) in HCOs, as the role of BI in addressing sustainability challenges.
Apple fruit preference and food mile problems under halal supply chain
Authors: Nazaruddin La Ode , Miah Md Tota , Susanty Aries , Fekete-Farkas Maria , Naárné Tóth Zsuzsanna , Balázs Gyenge 
Published: March 2024

Purpose
This study aims to uncover apple preference and consumption in Indonesia, to disclose the risk of non-halal contamination of apples and the importance of maintaining the halal integrity of apples along the supply chain and to uncover the impacts of food miles of apples along supply chain segmentation.

Design/methodology/approach
This study adopted mixed research methods under a fully mixed sequential dominant status design (QUAN → qual). Data were collected through a survey in some Indonesian provinces (N = 396 respondents). Samples were collected randomly from individual consumers. The qualitative data were collected through interviews with 15 apple traders in Indonesia. Data were analysed using crosstab, chi-square and descriptive analysis.

Findings
First, Muslim consumers believe in the risk of chemical treatment of apples because it can affect the halal status of apples. Second, Indonesian consumers consider the importance of halal certification of chemical-treated apples and the additives for apple treatments. Third, the insignificance of domestic apple preference contributes to longer food miles at the first- and middle-mile stages (preference for imported apples). Fourth, apple consumption and shopping distance contribute to the longer food miles problem at the last-mile stage. Fifth, longer food miles have negative impacts, such as emissions and pollution, food loss and waste, food insecurity, financial loss, slow development of the local economy and food unsafety.

Practical implications
This research has implications for the governments, farmers, consumers (society) and business sectors.

Originality/value
This study proposes a framework of food miles under a halal supply chain (halal food miles) to reduce the risk of food miles and improve halal integrity. The findings from this research have theoretical implications for the development of the food mile theory, halal food supply chain and green supply chain.
Outsourcing and entrepreneurial innovation in a transition economy: the moderating roles of private ownership and government support
Authors: Vo Dut Van , Phạm Phú Gia Minh , Nguyen Tri Giac 
Published: March 2024

PurposeThis study aims to study the moderating effects of private ownership and government support on the relationship between outsourcing and product innovation in entrepreneurial ventures in a transition economy.Design/methodology/approachThe data of 10,296 Vietnamese entrepreneurial ventures from the four rounds of the survey conducted by the General Statistics Office (GSO) of Vietnam to investigate the moderating effects of private ownership and government support on the association between outsourcing and entrepreneurial ventures’ product innovation performance. The Probit regression model is employed to estimate such associations.FindingsOur research uncovered that the impact of outsourcing on the likelihood of product innovation is more significant for entrepreneurial operations characterized by a substantial degree of private ownership and government backing as opposed to those without.Research limitations/implicationsThe results of our research indicated that the resource-based perspective and extended resource-based view (ERBV) are essential in examining the impact of gaining resources or skills from external sources on the growth of entrepreneurial enterprises. These ideas have significance and importance not just in industrialized economies but also in countries undergoing transition. Our findings suggest that entrepreneurial enterprises should have the ability to manage a wide range of resources and make decisions about which activities should be handled internally and which should be delegated to other parties.Practical implicationsOur findings also imply that entrepreneurial ventures should be able to control many resources and choose which tasks should be performed in-house and which should be outsourced to third parties.Originality/valueBy adopting and leveraging the resource-based view (RBV) and extended resource-based views (ERBV), our study developed a theoretical model about private ownership and government support for moderate outsourcing’s impact on entrepreneurial innovation in a transition economy.