bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Temporal and Tactile Cueing in Young Children With Childhood Apraxia of Speech: A Multiple Single-Case Design
Authors: Grigos Maria I. , Case Julie , Lu Ying , Lyu Zhuojun 
Published: March 2024

Purpose:
Childhood apraxia of speech (CAS) is a multivariate motor speech disorder that requires a motor-based intervention approach. There is limited treatment research on young children with CAS, reflecting a critical gap in the literature given that features of CAS are often in full expression early in development. Dynamic Temporal and Tactile Cueing (DTTC) is a treatment approach designed for children with severe CAS, yet the use of DTTC with children younger than 3 years of age has not been examined.

Method:
A multiple single-case design was employed to examine the use of DTTC in seven children with CAS (aged 2.5–5 years) over the course of 6 weeks of intervention. Changes in word accuracy were measured in treated words from baseline to posttreatment and from baseline to maintenance (6 weeks posttreatment). Generalization of word accuracy changes to matched untreated words was also examined. A linear mixed-effects model was used to estimate the change in word accuracy for treated and untreated words across all children from baseline to posttreatment and to maintenance. A quasi-Poisson regression model was used to estimate mean change and calculate effect sizes for treated and untreated words.

Results:
Group-level analyses revealed significant changes in word accuracy for treated and untreated words at posttreatment and maintenance. At the child level, six of seven children displayed medium-to-large effect sizes where word accuracy increased in an average of 3.4/5 words across all children. Each child displayed some degree of generalization to untreated targets, specifically for words with the same syllable shape as the treated words.

Conclusions:
These results demonstrate that DTTC can yield positive change in some young children with CAS. Key differences in each child's performance are highlighted.
A machine learning model for Alzheimer's disease prediction
Authors: Rani Pooja , Lamba Rohit , Sachdeva Ravi Kumar , Kumar Karan , Iwendi Celestine 
Published: March 2024

AbstractAlzheimer’s disease (AD) is a neurodegenerative disorder that mostly affects old aged people. Its symptoms are initially mild, but they get worse over time. Although this health disease has no cure, its early diagnosis can help to reduce its impacts. A methodology SMOTE‐RF is proposed for AD prediction. Alzheimer's is predicted using machine learning algorithms. Performances of three algorithms decision tree, extreme gradient boosting (XGB), and random forest (RF) are evaluated in prediction. Open Access Series of Imaging Studies longitudinal dataset available on Kaggle is used for experiments. The dataset is balanced using synthetic minority oversampling technique. Experiments are done on both imbalanced and balanced datasets. Decision tree obtained 73.38% accuracy, XGB obtained 83.88% accuracy and RF obtained a maximum of 87.84% accuracy on the imbalanced dataset. Decision tree obtained 83.15% accuracy, XGB obtained 91.05% accuracy and RF obtained maximum 95.03% accuracy on the balanced dataset. A maximum accuracy of 95.03% is achieved with SMOTE‐RF.
Digital twin‐based multi‐objective autonomous vehicle navigation approach as applied in infrastructure construction
Authors: Lei Tingjun , Sellers Timothy , Luo Chaomin , Cao Lei , Bi Zhuming 
Published: March 2024

AbstractThe widespread adoption of autonomous vehicles has generated considerable interest in their autonomous operation, with path planning emerging as a critical aspect. However, existing road infrastructure confronts challenges due to prolonged use and insufficient maintenance. Previous research on autonomous vehicle navigation has focused on determining the trajectory with the shortest distance, while neglecting road construction information, leading to potential time and energy inefficiencies in real‐world scenarios involving infrastructure development. To address this issue, a digital twin‐embedded multi‐objective autonomous vehicle navigation is proposed under the condition of infrastructure construction. The authors propose an image processing algorithm that leverages captured images of the road construction environment to enable road extraction and modelling of the autonomous vehicle workspace. Additionally, a wavelet neural network is developed to predict real‐time traffic flow, considering its inherent characteristics. Moreover, a multi‐objective brainstorm optimisation (BSO)‐based method for path planning is introduced, which optimises total time‐cost and energy consumption objective functions. To ensure optimal trajectory planning during infrastructure construction, the algorithm incorporates a real‐time updated digital twin throughout autonomous vehicle operations. The effectiveness and robustness of the proposed model are validated through simulation and comparative studies conducted in diverse scenarios involving road construction. The results highlight the improved performance and reliability of the autonomous vehicle system when equipped with the authors’ approach, demonstrating its potential for enhancing efficiency and minimising disruptions caused by road infrastructure development.
A decentralized framework for economic‐resilient operation of networked microgrids, considering demand response program
Authors: Doostizadeh Mohammad , Jalili Hasan , Babaee Abbas 
Published: March 2024

AbstractThe occurrence of natural disasters can disrupt the normal functioning of distribution networks. In this situation, the activeness of distribution networks in the sense of benefiting from energy sources and related structures such as microgrids (MGs) makes them benefit from the capability of structures such as MGs, in case of High‐Impact Low‐Probability (HILP) events, so that consumers are able to disconnect from main grid and trade with other MGs. Thus, the energy management of networked MGs needs a new operation structure to encourage them providing each other with the required energy by creating the necessary incentives. This paper presents a novel cooperative framework aimed at enhancing the resilience of MGs through the establishment of peer‐to‐peer (P2P) energy trading among their constituents. In the present model, MGs engage in energy transactions with one another, aiming to minimize costs through the cooperative operation of networked MGs. The utilization of the suggested model enables MGs to enhance network resilience within the framework of peer‐to‐peer energy transactions, while also achieving cost reductions in comparison to islanding and non‐cooperative operation. The numerical results obtained demonstrate the efficacy of the proposed methodology in enhancing the resilience of MGs and mitigating their operational expenses.
HIF-Stabilisatoren: aktueller Stellenwert bei der Therapie der renalen Anämie
Authors: Strutz Frank 
Published: March 2024

ZUSAMMENFASSUNGDie renale Anämie ist eine häufige Begleiterkrankung bei Patienten mit progredienter chronischer Niereninsuffizienz (CKD: „chronic kidney disease“). Im Stadium der Dialysepflicht sind etwa 80 % der Patienten betroffen und oft therapiebedürftig. Die renale Anämie ist weiterhin eine Ausschlussdiagnose, es müssen daher andere Ursachen für die Anämie ausgeschlossen werden. Die Standardtherapie bei vorliegendem Eisenmangel besteht in der Gabe von Eisen und nachfolgend Erythropoese stimulierenden Agenzien (ESA). Seit 2 Jahren steht in Deutschland mit Roxadustat der erste HIF-Stabilisator (HIF: Hypoxie induzierbarer Faktor) für eine orale Therapie der renalen Anämie zur Verfügung. Diese Präparate bieten weitere Vorteile in Bezug auf die reduzierte Notwendigkeit einer Eisensubstitution und die häufig gute Effektivität bei ESA-resistenten Patienten. Leider haben sie keine Vorteile in Bezug auf kardiovaskuläre Endpunkte, und zudem konnte die renale Progressionsrate gegenüber einer ESA-Vergleichstherapie nicht positiv beeinflusst werden. Positiv zu sehen sind die fehlenden Sicherheitshinweise in Ländern mit langjährigen Erfahrungen wie China und Japan ohne Hinweise auf ein erhöhtes Tumorrisiko, eine Verstärkung einer proliferativen Retinopathie oder ein vermehrtes Zystenwachstum bei Patienten mit autosomal-dominanter polyzystischer Nierenerkrankung.
Messung von Lebensqualität in der Nephrologie
Authors: Hartmann Claudia , Jaha Hanna , Hofmann Lisa , Schappert Anna , Rose Matthias 
Published: March 2024

ZUSAMMENFASSUNGIn Studien und bei der Zulassung neuer Medikamente oder Therapien ist die Messung des Einflusses einer Behandlung auf die gesundheitsbezogene Lebensqualität inzwischen Standard. In der Praxis wird das Potenzial der patientenberichteten Gesundheitsmerkmale noch immer unterschätzt und in der Routineversorgung nicht ausreichend genutzt. In diesem Artikel beschreiben wir den theoretischen Hintergrund der gesundheitsbezogenen Lebensqualität, erklären patientenberichtete Gesundheitsmerkmale und wie sie gemessen werden. Abschließend fassen wir die aktuellen Forschungsergebnisse zur gesundheitsbezogenen Lebensqualität bei Nierenersatztherapie zusammen.
Rhizarthrose: Resektionsarthroplastik versus
Resektionssuspensionsarthroplastik – immer noch der Goldstandard?
Authors: Tosun Saskia Carolin , Pietzsch Leonie Barbara , Held Manuel , Daigeler Adrien , Eisler Wiebke 
Published: March 2024

ZusammenfassungDie Rhizarthrose ist eine der häufigsten arthrotischen Veränderungen der Hand,
sodass in den vergangenen Jahren eine Vielzahl an Operationsmethoden entwickelt
wurden. Neben der „klassischen“ Resektionsarthroplastik mit Sehnenaufhängung
oder -interposition werden auch Daumensattelgelenksprothesen immer häufiger
angewendet. Diese kommen jedoch für einen Teil der Patienten wie bei
ausgeprägter Osteoporose, starker Nickelallergie, unzureichender Höhe des
Trapeziums oder STT-Arthrose nicht in Frage. Vor diesem Hintergrund wurde in der
vorliegenden Arbeit herausgearbeitet, ob die „klassischen“ Operationsmethoden
auch weiterhin ihre Daseinsberechtigung haben oder von den Prothesen abgelöst
werden. In einer retrospektiven Studie mit prospektiver Datenerhebung wurden 48
Hände von 45 Patienten 2,5 Jahre nach stattgehabter Resektionsarthroplastik/
Resektions-Suspensions-Interpositionsarthroplastik mittels Flexor carpi radialis
(FCR)- oder Abductor pollicis longus (APL)-Sehnenstreifen in den Jahren
2015–2018 bei diagnostizierter Rhizarthrose in den Stadien II und III nach Eaton
und Littler klinisch nachuntersucht. Das postoperative Outcome wurde anhand der
Beweglichkeit, Griffkraft, Zwei-Punkte-Diskrimination nach Weber, der
postoperativen Zufriedenheit hinsichtlich Schmerzen und Belastbarkeit sowie
anhand des DASH und MHQ-Fragebogens bewertet. Signifikante Unterschiede zeigten
sich weder bei der Dauer der Operation, der Arbeitsunfähigkeit, bis zur
Vollbelastung, den Schmerzen, der Zufriedenheit, noch bei der Griffkraft und
Beweglichkeit. Unabhängig von der verwendeten Operationsmethode bestand eine
nahezu freie Daumen- und Handgelenksbeweglichkeit sowie altersentsprechende
Handkraft. Ruheschmerzen bestanden selten, 48% waren schmerzfrei bei Belastung.
Beim DASH-Fragebogen wurden 20, 14 sowie 22 Punkte und beim MHQ 76, 79 und 79
Punkte erzielt. Somit zeigten die „klassischen“ Operationstechniken ein gutes
postoperatives Ergebnis mit hoher Patientenzufriedenheit. „Neuere Verfahren“ wie
die Endoprothese bieten vielversprechende Ergebnisse bezüglich einer schnellere
Regenerationszeit. Dem gegenüberzustellen sind jedoch eine verlängerte
Operationsdauer und höhere Materialkosten, sodass die Resektionsarthroplastiken
bei geringem Komplikationspotential und einer niedrigeren Revisionsrate ein
langbewährtes Verfahren darstellen und insbesondere bei relativen
Kontraindikationen für eine Endoprothese weiterhin genutzt werden sollten.
Pflegekammer auf der Kippe
Authors: Lukuc Sarah 
Published: March 2024

ZusammenfassungDie Vorzeichen für eine Pflegekammer Baden-Württemberg stehen nicht gut. Zumindest wenn man der Prognose
von Sozialminister Manfred Lucha (Grüne) glaubt, die er nur fünf Tage nach Ablauf der Einspruchsfrist
verkündete – und damit ungeplant früh.
Trainieren Sie sich glücklich
Authors: Spantzel Dagmar 
Published: March 2024

ZusammenfassungResiliente Führungskräfte in der Pflege können effektiver führen, Stress bewältigen und damit
Inspirationsquelle für ihre Mitarbeiter sein. So schaffen sie ein unterstützendes Arbeitsumfeld, in dem
alle gerne arbeiten und selbst die Verantwortung für ihr Glück in die Hand nehmen.
Espondilólise e espondilolistese em atletas
Authors: Lima Marcos Vaz de , Caffaro Maria Fernanda Silber , Santili Claudio , Watkins IV Robert G. 
Published: March 2024

ResumoEste artigo é uma atualização do tema espondilólise e espondilolistese em atletas, do diagnóstico ao tratamento, baseando-se na experiência dos nossos serviços juntamente com uma revisão da literatura.
Homeopathy for Chronic Non-specific Low Back Pain: Study Protocol for a Randomized, Double-Blind, Crossover, Placebo-Controlled Clinical Trial Investigating the Efficacy of the Biotherapic Lumbar Vertebra (The BIOVERT Trial)
Authors: Adler Ubiratan Cardinalli , Adler Maristela Schiabel , Carrer Helen Nogueira , Dias Deise Lilian Costa , Diniz José Nelson Martins , Grossi Manoela Gomes , Sugimoto Neli Aparecida Martins , Martinez Edson Zangiacomi 
Published: March 2024

Abstract
Background Chronic non-specific low back pain (CNSLBP) lacks identifiable anatomical pathology and effective pharmacological treatment. Alternative approaches in homeopathy, specifically clinical homeopathy, utilize ultra-diluted (potentized) biological products. In Brazil, standardized biotherapics from sheep tissues, particularly fifty-millesimal (LM) potencies of sheep Lumbar Vertebra, have shown promise in alleviating CNSLBP.
Objectives Our objective is to present the study protocol of a clinical trial that will assess the efficacy and safety of the biotherapic Lumbar Vertebra LM2 in the short-term management of CNSLBP and to estimate its therapeutic duration.
Methods A randomized, double-blind, crossover, placebo-controlled clinical trial spanning 8 weeks per participant was designed. Participants will include 120 individuals (aged 20 to 60 years) with clinically diagnosed CNSLBP by the study's physiotherapist. Exclusion criteria are radicular pain, signs of radiculopathy, specific lumbar spine disorders, pregnancy, or puerperium (up to 60 days after delivery). The medical intervention includes participants being randomly assigned to one of two treatment sequences: homeopathy–placebo or placebo–homeopathy. The treatments will consist of Lumbar Vertebra LM2 oral solution, topical cream, and indistinguishable placebos. Each treatment period will span 2 weeks, with a 4-week washout interval between them. Primary outcome is the assessment of changes in self-reported pain levels using the numeric rating scale (NRS) score, analyzed with a random effects model across both treatment periods. Secondary outcomes are assessment of changes in self-reported disability levels using the Oswestry Disability Index (ODI), analyzed with a random effects model across both treatment periods, and pain and disability variations, evaluated by the NRS score and ODI respectively, after the first and second treatment periods. Adverse events will be assessed at weeks 2 and 8. Pain medications will be used concomitantly. Adherence will be evaluated by the weight of medication returned/standard weight.
Discussion The BIOVERT (Bioactive Vertebra) trial protocol is designed to investigate a homeopathic strategy for short-term CNSLBP treatment. Favorable outcomes for homeopathy could prompt subsequent studies evaluating the long-term effectiveness of LM potencies of Lumbar Vertebra for CNSLBP.
Trial Registration UMIN Clinical Trials Registry – ID: UMIN000051957
Explaining Variability in Electronic Health Record Effort in Primary Care Ambulatory Encounters
Authors: Overhage J. Marc , Qeadan Fares , Choi Eun Ho Eunice , Vos Duncan , Kroth Philip J. 
Published: March 2024

Abstract
Background Electronic health record (EHR) user interface event logs are fast providing another perspective on the value and efficiency EHR technology brings to health care. Analysis of these detailed usage data has demonstrated their potential to identify EHR and clinical process design factors related to user efficiency, satisfaction, and burnout.
Objective This study aimed to analyze the event log data across 26 different health systems to determine the variability of use of a single vendor's EHR based on four event log metrics, at the individual, practice group, and health system levels.
Methods We obtained de-identified event log data recorded from June 1, 2018, to May 31, 2019, from 26 health systems' primary care physicians. We estimated the variability in total Active EHR Time, Documentation Time, Chart Review Time, and Ordering Time across health systems, practice groups, and individual physicians.
Results In total, 5,444 physicians (Family Medicine: 3,042 and Internal Medicine: 2,422) provided care in a total of 2,285 different practices nested in 26 health systems. Health systems explain 1.29, 3.55, 3.45, and 3.30% of the total variability in Active Time, Documentation Time, Chart Review Time, and Ordering Time, respectively. Practice-level variability was estimated to be 7.96, 13.52, 8.39, and 5.57%, respectively, and individual physicians explained the largest proportion of the variability for those same outcomes 17.09, 27.49, 17.51, and 19.75%, respectively.
Conclusion The most variable physician EHR usage patterns occurs at the individual physician level and decreases as you move up to the practice and health system levels. This suggests that interventions to improve individual users' EHR usage efficiency may have the most potential impact compared with those directed at health system or practice levels.
Back to Babies: Reducing Documentation Time in the NICU
Authors: Patel Shama Y. , Rose Rebecca S. , Webber Emily C. 
Published: March 2024

Abstract
Background There is no accepted best practice for generation and content of daily progress notes in the neonatal intensive care unit (NICU).
Objectives This study aimed to implement a consistent documentation standard process for a neonatology provider group at a level IV tertiary care NICU. The primary aim was to improve timeliness of daily progress note completion. Secondary aims were to maintain or improve clinician satisfaction, reduce variability, and reduce attending neonatologist electronic medical record (EMR) documentation tasks.
Methods We formed a work group including advanced practice providers (APPs) and physicians from the NICU that met over 6 months to define the ideal NICU documentation content, map the workflow for documentation, identify gaps in EMR content, and create solutions for each gap. Baseline assessment included a change readiness survey to identify barriers to workflow change and a review of neonatologist signature timestamp to determine time to note completion. Twenty random progress notes were sampled weekly for 6 months prior to implementation of new workflow as well as 6 months postimplementation. Average time to note completion was compared in the pre- and postintervention groups.
Results In total, 962 notes were sampled, 481 each in the pre- and postintervention states. Twenty neonatologists were captured in the preintervention state, 24 in the postintervention state, 18 were captured in both samples. Final note completion time mean improved from 10 hours and 32 minutes (from starting note to final sign) to 8 hours and 40 minutes (p < 0.01). Those sampled in both epochs improved from 10 hours and 6 minutes to 8 hours and 30 minutes (p < 0.05).
Conclusion Progress notes generated by neonatologists are completed earlier than those generated by an APP with a Neonatologist addendum. Specialty-specific education and training are critical to high satisfaction in large EMR workflow transitions.
Emergent modified gravity
Authors: Bojowald Martin , Duque Erick I 
Published: March 2024

Abstract
A complete canonical formulation of general covariance makes it possible to construct new modified theories of gravity that are not of higher-curvature form, as shown here in a spherically symmetric setting. The usual uniqueness theorems are evaded by using a crucial and novel ingredient, allowing for fundamental fields of gravity distinct from an emergent space-time metric that provides a geometrical structure to all solutions. As specific examples, there are new expansion-shear couplings in cosmological models, a form of modified Newtonian dynamics can appear in a space-time covariant theory without introducing extra fields, and related effects help to make effective models of canonical quantum gravity fully consistent with general covariance.
Derivation of Miller’s rule for the nonlinear optical susceptibility of a quantum anharmonic oscillator
Authors: Meyer Maximilian T , Schindlmayr Arno 
Published: March 2024

Abstract
Miller’s rule is an empirical relation between the nonlinear and linear optical coefficients that applies to a large class of materials but has only been rigorously derived for the classical Lorentz model with a weak anharmonic perturbation. In this work, we extend the proof and present a detailed derivation of Miller’s rule for an equivalent quantum-mechanical anharmonic oscillator. For this purpose, the classical concept of velocity-dependent damping inherent to the Lorentz model is replaced by an adiabatic switch-on of the external electric field, which allows a unified treatment of the classical and quantum-mechanical systems using identical potentials and fields. Although the dynamics of the resulting charge oscillations, and hence the induced polarizations, deviate due to the finite zero-point motion in the quantum-mechanical framework, we find that Miller’s rule is nevertheless identical in both cases up to terms of first order in the anharmonicity. With a view to practical applications, especially in the context of ab initio calculations for the optical response where adiabatically switched-on fields are widely assumed, we demonstrate that a correct treatment of finite broadening parameters is essential to avoid spurious errors that may falsely suggest a violation of Miller’s rule, and we illustrate this point by means of a numerical example.
Anisotropy and paramagnetism of QCD matter with an anomalous magnetic moment
Authors: He Rui , Wen Xin-Jian 
Published: March 2024

Abstract
We employ the Polyakov-loop enhanced Nambu–Jona-Lasinio model incorporating the quark anomalous magnetic moment to investigate the anisotropy structure and the renormalized magnetization of magnetized quark matter at finite temperature. The ultraviolet divergences and nonphysical oscillatory behavior are eliminated by the vacuum magnetic regularization scheme. With a parametrization of the anomalous magnetic moment that is proportional to the square of the chiral condensate, the renormalized magnetization is enlarged by the strong magnetic field so that the anisotropy becomes more apparent. The inflection point of the renormalized magnetization indicates the pseudocritical temperature for the chiral crossover. We find that the results with the anomalous magnetic moment are closer to the lattice quantum chromodynamics data. The connection between the paramagnetism and the chiral transition provides new insight into a magnetohydrodynamics description of hot and dense QCD matter produced in heavy-ion collisions.