bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Financial Development Reduces Poverty Level in Nigeria? (1980-2020)
Authors: RAUFF SALIU ADEJARE , ADEGBOYE ABIODUN ADEWALE 
Published: April 2024

Abstract
This study investigated the effect of financial development on poverty level in Nigeria. This paper deviated from extant studies by adopting a more robust measures of financial development which disaggregated into three for in-depth analysis sourced from International Monetary Fund’s, International Financial Statistics database making the overall financial development index (FD) as baseline model to serve as key independent variable while indices of financial institution (FI) and financial market (FM) served as key independent variables for robustness checks. These were with a view to do in-depth analyses to establishing which index of financial development reduces poverty level in Nigeria covering the period between 1980 and 2020. The result of the overall financial development index and poverty level is statistically significant and positively related (t = 3.3583, p < 0.05) Also, a negative and statistically insignificant relationship was established between financial institution index and poverty level (t = -1.3725, p > 0.05) while a statistically insignificant positive relationship was established between financial market index (t = 0.3785, p > 0.05) and poverty level. The study therefore concludes that poverty level could only be reduced when financial development is promoted in Nigeria.
A Multi-Center Evaluation of a Novel IVF Cryostorage Device in an Active Clinical Setting
Authors: Collins Michael , Bailey Jessica , Tremont Jordan , Laasch Natalee , McDonough Cali , Dufault Andrea , Martin Jessica , Li Albert , Pitts Stefan , Kontaxis Emma , Slifkin Richard , Lee Joseph , Reed Laura , Swain Jason , Schoolcraft William , String Ellen , Woodhull Robert , Souza Ashley 
Published: April 2024

Abstract

Purpose
To evaluate the safety, function, and integration of a novel automated software-guided cryostorage system in an active IVF laboratory setting.
Methods
The Investigational Device (ID) was installed at 3 IVF laboratories (sites: α, β, and γ). A total of 15 embryologists were trained to use the ID. Mock patient specimens containing mirrored live patient data were handled using the ID. Temperature readings were recorded every minute. Successful identification, storage, and retrieval of patient specimens by the ID were evaluated. To assess an LN2 pressure builder, the frequency of use and events of workflow interruption were logged. Student’s t-test was used to determine statistical significance.
Results
The ID was in active use for 164 days total. During this time, 329 mock patient egg and embryo cohorts were handled by the ID. The mean ± SD temperatures during active use were: α, -176.57 ± 1.83OC; β, -178.21 ± 2.75OC; γ, -178.98 ± 1.74 and did not differ significantly. The highest recorded temperatures were: α, -165.14OC; β, -157.41OC; γ, -164.45OC. A total of 1064 automation transactions on 409 specimen vessels were performed. Data was managed on 1501 eggs and embryos. The ID did not lose or misplace any specimen data or vessels, and no specimen was exposed to a detrimental (>-150OC) temperature excursion. Over the 25 LN2 pressure builder usages during 99 total days, there was 1 occurrence where usage interrupted workflow due to a lack of LN2 pressure.
Conclusions
The ID has advantages over the current manual-based cryostorage systems, including radio frequency identification (RFID) tracking, automation of manual tasks, and software guidance to ensure accurate specimen storage and retrieval. The results of this study indicate that the ID can be easily integrated into active IVF laboratories.
Update on the Detection of Frailty in the Older Adult: A Multicenter Cohort Big Data-Based Study Protocol
Authors: Fernández-Carnero Samuel , Martínez-Pozas Oliver , Pecos-Martín Daniel , Gómez Armando Pardo , Cuenca-Zaldívar Juan Nicolás , Sánchez-Romero Eleuterio A. 
Published: April 2024

Abstract

Background This study aims to investigate the relationship between muscle activation variables assessed via ultrasound and the comprehensive assessment of geriatric patients, as well as to analyze ultrasound images to determine their correlation with mobi-mortality factors in frail patients. Methods The present cohort study will be conducted in 500 older adults diagnosed with frailty. A multicenter study will be conducted among the day care centers and nursing homes. This will be achieved through the evaluation of frail older adults via instrumental and functional tests, along with specific ultrasound images to study sarcopenia and nutrition, followed by a detailed analysis of the correlation between all collected variables. Discussion This study aims to investigate the correlation between ultrasound-assessed muscle activation variables and the overall health of geriatric patients. It addresses the limitations of previous research by including a large sample size of 500 patients and measuring various muscle parameters beyond thickness. Additionally, it aims to analyze ultrasound images to identify markers associated with higher risk of complications in frail patients. The study involves frail older adults undergoing functional tests and specific ultrasound examinations. A comprehensive analysis of functional, ultrasound, and nutritional variables will be conducted to understand their correlation with overall health and risk of complications in frail older patients. Trial registration The study was approved by the Research Ethics Committee of the Hospital Universitario Puerta de Hierro, Madrid, Spain (Act nº 18/2023). In addition, the study was registered with ClinicalTrials.gov (NCT06218121).
A Keep-It-Simple embolisation approach to treat Pelvic Congestion Syndrome without compromising clinical effectiveness.
Authors: Liang Eisen , Wong Wai Yan Timothy , Parvez Razeen , Chan Michael , Brown Bevan 
Published: April 2024

Abstract
Background:
There are two approaches to treat Pelvic Congestion Syndrome (PCS): 1. the Keep-It-Simple (KIS) approach, embolising only the refluxing vein(s), typically only the left ovarian vein (LOV), unless right ovarian vein (ROV), left or right internal iliac vein (IIV) tributaries were also refluxing; and 2. the extensive (EXT) approach, embolising empirically almost all of the LOV, ROV, left and right IIV tributaries.
The aim of the study is to show if the KIS approach is sufficient to effectively treat PCS, minimising the number of veins treated and number of coils used, and without injecting sclerosing agents into the pelvic veins or the use of occlusion balloons.
Materials and Methods:
This is a single institution retrospective cohort study. Our records identified 154 women who had undergone venogram for possible PCS, with a view to proceed with embolisation. Refluxing veins were treated with the KIS approach, using minimal number of coils “sandwiching” sclerosing foam. Short term follow up was conducted at 6 weeks; long term follow-ups (between 12-60 months) were conducted by an electronic survey consists of 19 questions, assessing pelvic pain/ pressure, leg and back pain, fatique, bladder and menstrual symptoms.
Results:
Most women (73.4%) required unilateral OV embolisation only; just 14.4% required bilateral OV embolisation; and only 12.2% required pelvic vein embolisation. Most cases required only 4 pushable coils. Clinical success was 89.1% at 6 weeks and 83.7% at 1-5 years. VAS drop of 5.2 (7.8 to 2.7) was achieved. There was no coil dislodgement or other complications.
Conclusion:
The KIS approach embolising only the refluxing veins can achieve similar effective clinical outcome for PCS as the EXT approach. This carries implications for potential savings in procedure time, cost, and radiation does. The EXT approach of empirically embolising all 4 sets of veins may not be necessary to achieve an effective outcome.
Effects of Quarry Dust on the Engineering Properties of Lateritic Soils for Highway Construction in Imo State, Nigeria
Authors: Njoku Fidelis Chidiebere , Onyemaechi Abigail Amarachi , Ibearugbulem Owuamanam Mathias , Okere Chinenye Elizabeth 
Published: April 2024

Abstract
This study investigated the impact of quarry dust on the engineering properties of lateritic soils with a focus on its potential application in highway construction within Imo State, Nigeria. Lateritic soils, widely used in road projects due to their availability, often exhibit suboptimal engineering properties such as low strength and high plasticity, posing challenges to highway performance and durability. From a borrow pit in Obinze, Owerri West Local Government Area, Imo State, a soil sample was taken at a depth of 2m below the surface, and subjected to laboratory tests which include; Specific gravity, Particle size distribution, Atterberg limits, Compaction test and California Bearing Ratio (CBR) tests, all in accordance to British Standard 1377-2:1990. The results from the tests carried out revealed a specific gravity of 2.52, coefficient of uniformity of 3.15, plasticity index of 16.72%, and a CBR value of 3.16%. These findings indicated that the soil was unsuitable for road construction due to its high plasticity and low CBR value. To mitigate these shortcomings, the soil was stabilized with varying proportions of quarry dust (ranging from 15% to 75%). The addition of quarry dust resulted in reduced plasticity indices (ranging from 16.19% to 12.40%) and increased CBR values (ranging from 3.51% to 9.44%). However, even with the highest 75% quarry dust addition, the transformed soil still fell short of highway construction standards, highlighting the need to explore alternative materials or more effective soil stabilization methods to meet the required engineering specifications.
Characterizing the Dynamics of Multi-Scale Global Severe Weather Events
Authors: Frank Lawrence R. , Galinsky Vitaly L. , Zhang Zhenhai , Ralph F. Martin 
Published: April 2024

Abstract

The quantitative characterization and prediction of localized severe weather events that emerge as coherences generated by the highly non-linear interacting multivariate dynamics of global weather systems poses a significant challenge whose solution is increasingly important in the face of climate change where weather extremes are on the rise. As weather measurement systems (multiband satellite, radar, etc) continue to dramatically improve, increasingly complex time-dependent multivariate 3D datasets offer the potential to inform such problems but pose an increasingly daunting computational challenge. Here we describe the application to global weather systems of a novel computational method called the Entropy Field Decomposition (EFD) capable of efficiently characterizing coherent spatiotemporal structures in non-linear multivariate interacting physical systems. Using the EFD derived system configurations, we demonstrate the application of a second novel computational method called Space-Time Information Trajectories (STITs) that reveal how spatiotemporal coherences are dynamically connected. The method is demonstrated on the specific phenomenon known as atmospheric rivers (ARs) which are a prime example of a highly coherent, in both space and time, severe weather phenomenon whose generation and persistence are influenced by weather dynamics on a wide range of spatial and temporal scales. The EFD reveals how the interacting wind vector field and humidity scalar field couple to produce ARs, while the resulting STITS reveal the linkage between ARs and large-scale planetary circulations. The focus on ARs is also motivated by their devastating social and economic effects that have made them the subject of increasing scientific investigation to which the EFD may offer new insights. The application of EFD and STITs to the broader range of severe weather events is discussed.
Post-Translational Modification Prediction via Prompt-Based Fine-Tuning of a GPT-2 Model
Authors: Shrestha Palistha , Kandel Jeevan , Tayara Hilal , Chong Kil To 
Published: April 2024

Abstract
Post-translational modifications (PTMs) are pivotal in modulating protein functions, influencing key cellular processes such as signaling, localization, and protein degradation. The complexity of these biological interactions necessitates efficient predictive methodologies. In this work, we introduce PTMGPT2, an interpretable protein language model that utilizes prompt-based fine-tuning to improve its accuracy and generalizability in precisely predicting PTMs. Drawing inspiration from recent advancements in GPT-based architectures, PTMGPT2 adopts an unsupervised learning approach to identify PTMs. It utilizes a custom prompt to guide the model through the subtle linguistic patterns encoded in amino acid sequences, generating tokens indicative of PTM sites. To provide interpretability, we visualize attention profiles from the model’s final decoder layer, elucidating sequence motifs essential for molecular recognition and modification variability. Furthermore, we conducted analyses to investigate the effects of mutations at or near PTM sites, thereby offering deeper insights into protein functionality. Our analysis encompasses a comprehensive dataset comprising 3,88,084 modification sites across 19 distinct PTM types, facilitating the identification of novel PTM sites. Comparative assessments reveal that PTMGPT2 outperforms existing methods by an average 5.45% in MCC, underscoring its potential in identifying novel therapeutic strategies, disease associations, and drug targets.
Оптимизация терапии у пациентов с впервые диагностированной диффузной В-крупноклеточной лимфомой: эффективность и безопасность программы R-SD-EPOCH ± HDMTX в рамках одноцентрового нерандомизированного проспективного клинического исследования (предварительные результаты)
Authors: Мингалимов Марат Альбертович , Барях Е. А. , Мисюрина Е. Н. , Поляков Ю. Ю. , Желнова Е. И. , Яцков К. В. , Макешова А. Б. , Толстых Т. Н. , Чуднова Т. С. , Иванова Д. Д. , Кочнева О. Л. , Зотина Е. Н. , Гаглоева Д. Э. , Стрюкова В. В. , Герасимов Г. Д. , Самсонова И. В. , Лысенко М. А. 
Published: April 2024

Aim. To assess clinical efficacy and safety of the intensified program R-SD-EPOCH ± HDMTX (R-split-dose-EPOCH ± high-dose MTX) in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL).
Materials & Methods. From October 2022 to August 2023, 25 newly diagnosed DLBCL patients were enrolled into the trial protocol. Data of 23 patients were analyzed. The age of patients was 46–70 years (median 63 years); there were 13 women and 10 men. Stage II with bulky tumor lesion was registered in 7 patients; 16 patients showed advanced stages (III and IV). The IPI stratification yielded 13 high-risk, 7 intermediate-high risk, and 3 intermediate-low risk patients. In accordance with the CNS-IPI criteria, 14 patients were listed as high-risk. All 23 patients were treated with R-SD-EPOCH (rituximab, prednisolone, and cyclophosphamide; etoposide, vincristine, and doxorubicin were administered in fractionated doses). High-dose methotrexate as part of R-SD-EPOCH (continuous 3 g/m2 infusion over 12 hours) was administered exclusively to the CNS-IPI high-risk patients. They received it on Day 16 of R-SD-EPOCH ± HDMTX cycles 2, 4, and 6.
Results. The methotrexate-free R-SD-EPOCH regimen was administered throughout the whole program to 9 patients, whereas 14 patients received R-SD-EPOCH ± HDMTX (methotrexate was administered only in cycles 2, 4, and 6). Overall response in the whole cohort (n = 23) was 95 %. Interim PET-CTs were performed after chemotherapy cycles 2 and 4 in 21 patients. Complete metabolic response was achieved in 20 (95 %) patients, whereas partial metabolic response was registered in 1 (5 %) patient. One of the remaining 2 patients was undergoing initial treatment by the time of analysis. The other one with partial response assessed by contrast-enhanced CT, died after surgery for colon perforation followed by localized peritonitis. The patients in the present trial showed equal 10-month PFS and OS rates of 85 % (median not reached; 95% CI 66.4–100.0 %). Hematologic toxicity grade 3/4 was identified in 14 (60 %) patients, and non-hematologic toxicity was observed in 9 (35 %) patients.
Conclusion. The preliminary results of the present clinical trial of the intensified program R-SD-EPOCH ± HDMTX as the first method for the drug treatment of DLBCL demonstrate high efficacy and acceptable safety profile. The data obtained point towards the feasibility of continuing this clinical trial.
REPRESENTASI KONSEP DIRI REMAJA PADA FILM LADY BIRD (ANALISIS SEMIOTIKA ROLAND BARTHES)
Authors: Anugrah Ifti , Suwarto Dyna Herlina 
Published: April 2024

Penelitian ini bertujuan untuk mengetahui representasi konsep diri remaja dalam film Lady Bird melalui adegan-adegan yang memuat tanda pencarian jati diri remaja dan mengetahui pesan yang ingin disampaikan dari makna representasi film Lady Bird. Penelitian ini adalah analisis konten kualitatif dengan pendekatan semiotika Roland Barthes. Model semiotika Roland Barthes digunakan untuk menyusuri tanda dan makna dari rangkaian audiovisual yang ditampilkan film yang diteliti. Sumber data primer adalah adegan-adegan film yang berkaitan dengan konsep diri remaja. Sumber data sekunder literatur dan kepustakaan digunakan untuk proses analisis data. Analisis semiotika Roland Barthes terdiri dari penanda, petanda, makna denotatif, makna konotatif, dan mitos yang didapatkan dari adegan yang dianalisis. Hasil penelitian menunjukkan bahwa; 1) film Lady Bird memuat representasi konsep diri remaja sesuai dengan kondisi yang mempengaruhi pembentukan konsep diri yaitu, a) usia kematangan, b) penampilan diri, c) kepatuhan seks, d) nama dan julukan, e) hubungan keluarga, f) teman-teman sebaya, g) kreativitas, h) cita-cita; 2) pesan yang dapat diambil dari analisis terdapat dua pesan utama, a) pesan pertama yaitu konsep diri remaja cenderung positif dipengaruhi kondisi keluarga yang mendukung dan harmonis, dan b) pesan kedua yaitu konsep diri remaja cenderung positif terbentuk oleh pengalaman dari lingkungan sosial yang mampu diatasi, dari pengalaman tersebut remaja mampu belajar sehingga terjadi pendewasaan diri. Kata kunci: Roland Barthes, representasi, konsep diri remaja, film
STRATEGI KOMUNIKASI PEMASARAN DALAM PENGEMBANGAN WISATA PANTAI MENGANTI
Authors: Nurhalimah Nurhalimah , Widiarti Pratiwi Wahyu 
Published: April 2024

Penelitian ini bertujuan untuk mengetahui strategi komunikasi pemasaran dalam mengembangkan wisata Pantai Menganti. Jenis penelitian ini adalah penelitian deskriptif dengan pendekatan kualitatif. Penentuan informan menggunakan purposive sampling. Informan utama adalah Ketua Pengelola dan Pokja Pemasaran, informan pendukung adalah pengunjung objek wisata Pantai Menganti. Pengumpulan data dilakukan dengan wawancara, observasi, dan dokumentasi. Analisis data dilakukan melalui tahap-tahap pengumpulan data, reduksi data, sajian data, dan penarikan kesimpulan. Pemeriksaan keabsahan data dilakukan dengan triangulasi sumber. Hasil penelitian menunjukkan bahwa produk yang ditawarkan Pantai Menganti berupa pantai berpasir putih, perbukitan hijau, susur laut, surfing dan tebing karst. Pantai Menganti menerapkan konsep one ticket dengan harga sebesar Rp. 12.500,-. Jalan menuju Pantai Menganti sudah bagus dengan jalan beraspal, tetapi akses jalan sulit dilalui karena banyaknya tanjakan dan turunan yang curam. Strategi kegiatan promosi meliputi delapan langkah yaitu khalayak yang dituju adalah agen travel dan keluarga, tujuan dari komunikasi pemasaran untuk meningkatkan jumlah kunjungan dan pendapatan, rancangan pesan dibuat berupa pesan menarik guna menarik perhatian wisatawan, saluran komunikasi personal menggunakan pameran dan festival, komunikasi nonpersonal menggunakan media cetak dan media sosial, anggaran promosi tidak ditentukan disetiap bulannya karena kegiatan promosi berbeda-beda, bauran promosi terdiri dari periklanan, penjualan personal, pemasaran dari mulut ke mulut, dan promosi penjualan, tolak ukur keberhasilan promosi dilihat dari jumlah tiket yang terjual, dan komunikasi pemasaran objek wisata Pantai Menganti dikelola oleh Pokja Pemasaran.Kata kunci: Strategi, komunikasi pemasaran, Pantai Menganti.
REPRESENTASI KEKERASAN DALAM RUMAH TANGGA PADA FILM RAKSASA DARI JOGJA (ANALISIS SEMIOTIKA ROLAND BARTHES)
Authors: Wijayantie Yunita Noor , Suranto Suranto 
Published: April 2024

ABSTRAKPenelitian ini bertujuan untuk mendeskripsikan; 1) representasi kekerasan dalam rumah tangga melalui tanda-tanda yang terkandung dalam film Raksasa dari Jogja menurut pendekatan semiotika Roland Barthes; 2) pesan yang disampaikan melalui tanda audiovisual kepada audiens dalam film Raksasa dari Jogja. Penelitian ini menggunakan pendekatan kualitatif dengan metode analisis semiotika Roland Barthes. Objek penelitian yang dipilih adalah film Raksasa dari Jogja karya Monty Tiwa. Teknik pengumpulan data yang digunakan adalah dokumentasi dan studi pustaka terhadap konten yang terkandung dalam film Raksasa dari Jogja berdasarkan landasan teori yang ada. Analisis data menggunakan model analisis semiotika Roland Barthes, yang terdiri atas penanda, petanda, makna denotatif, makna konotatif, dan mitos yang ditarik berdasarkan teori dari adegan dan shot yang dianalisis. Hasil penelitian menunjukkan bahwa; 1) Terdapat lima kajian representasi KDRT yang tergambarkan dalam film Raksasa dari Jogja yaitu; a) Penyebab terjadinya KDRT dalam film, yaitu adanya pengaruh dari budaya patriarki sehingga menempatkan ayah Bianca sebagai kepala keluarga yang berkuasa. b) Penyebab KDRT terus terjadi yaitu ketergantungan secara ekonomi ibu Bianca pada ayah Bianca sehingga membuat sang ibu memaklumi tindak kekerasan yang dilakukan oleh suaminya. c) Bentuk-bentuk KDRT yang terjadi yaitu kekerasan fisik dan psikis yang dialami oleh Bianca dan ibunya oleh sang ayah. d) KDRT berdampak langsung berupa luka fisik yang dialami oleh ibu Bianca hingga dirawat di rumah sakit, sedangkan dalam jangka panjang mengalami gangguan psikis berupa ketakutan yang berlebihan kepada ayah Bianca dan terjadinya perceraian diantara mereka. KDRT berdampak pula pada anak yaitu Bianca, pada kondisi psikologis yaitu traumatik. e) Penyelesaian kasus KDRT secara hukum dilakukan melalui langkah perceraian antara ibu dan ayah Bianca, selain itu sang ayah juga mendapatkan hukuman pidana. 2) Pesan yang disampaikan melalui tanda audiovisual kepada penonton dalam film Raksasa dari Jogja yaitu a) Film Raksasa dari Jogja merepresentasikan kekerasan dalam rumah tangga yang dilakukan oleh Ayah Bianca terhadap Bianca dan Ibunya. Sehingga dapat disimpulkan bahwa kekerasan dalam rumah tangga terjadi pada perempuan karena adanya pengaruh budaya patriarki yang masih kuat. b) Film ini lebih menonjolkan dampak-dampak dari KDRT, dibuktikan dari adanya 13 adegan yang merepresentasikan dampak KDRT. c) Kebiasaan ayah Bianca menyelesaikan masalah dengan kekerasan akan terus terjadi apabila Ibu Bianca menerima dan pasrah begitu saja. d) Segala bentuk kekerasan tidak dapat dianggap lumrah sehingga harus dihindari dengan meninggalkan pelaku kekerasan dan melaporkannya pada pihak berwajib karena termasuk dalam tindak pidana. Kata kunci: representasi kekerasan, KDRT, Raksasa dari Jogja, semiotika Roland Barthes