bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D Modeling of Self-Expandable Valves for PPVI in Distinct RVOT Morphologies
Authors: Odemis Ender , Aka İbrahim Başar , Kızılkaya Mete Han 
Published: February 2025

Abstract
Tetralogy of Fallot often requires transannular patch repair, leading to pulmonary insufficiency. Percutaneous pulmonary valve implantation (PPVI) with self-expandable valves offers a promising alternative, especially for enlarged right ventricular Queryoutflow tracts (RVOT). Five RVOT types identified in patients with Tetralogy of Fallot reflect anatomical variations due to disease and prior surgeries. This study assesses the Pulsta THV® valve’s in vitro hemodynamic performance across these RVOT morphologies using 3D-printed models. Five RVOT morphologies were recreated as 3D models from patient-specific imaging data. The Pulsta THV® valves, available in 28, 30, and 32 mm sizes, were evaluated using the ViVitro Pulse Duplicator System at three cardiac outputs (2, 3.5, and 5 L/min). Hemodynamic performance was assessed by measuring regurgitation rates and pressure gradients in the left and right pulmonary arteries. The Pulsta THV® performed optimally in RVOT Types 1 and 2, demonstrating lower regurgitation rates and pressure gradients, particularly with larger valve sizes. Conversely, RVOT Types 3 and 5 showed increased pressure gradients and hemodynamic variability, indicating less favorable outcomes. The results highlighted the critical role of precise anatomical compatibility, with larger valve sizes proving more effective in enlarged RVOT geometry. Valve sizes tailored to specific RVOT morphologies can enhance PPVI outcomes. Types 1 and 2 are ideal for PPVI, while Types 3 and 5 present challenges due to hemodynamic variability. This study supports 3D modeling and in vitro testing for pre-procedural planning to reduce complications, with future research exploring dynamic imaging and materials mimicking tissue properties.
Small Inertia Limit for Coupled Kinetic Swarming Models
Authors: Choi Young-Pil , Fagioli Simone , Iorio Valeria 
Published: February 2025

Abstract
We investigate various versions of multi-dimensional systems involving many species, modeling aggregation phenomena through nonlocal interaction terms. We establish a rigorous connection between kinetic and macroscopic descriptions by considering the small inertia limit at the kinetic level. The results are proved either under smoothness assumptions on all interaction kernels or under singular assumptions for self-interaction potentials. Utilizing different techniques in the two cases, we demonstrate the existence of a solution to the kinetic system, provide uniform estimates with respect to the inertia parameter, and show convergence toward the corresponding macroscopic system as the inertia approaches zero.
The chlorite adduct of aquacobalamin: contrast with chlorite dismutase
Authors: Lehene Maria , Zagrean-Tuza Cezara , Iancu Stefania D. , Cosma Sergiu-Raul , Brânzanic Adrian M. V. , Silaghi-Dumitrescu Radu , Stoean Bianca 
Published: February 2025

Abstract
In the reaction of aquacobalamin (aquaCbl) with chlorite, a stable species is detected and assigned as a Co(III)–chlorite complex, Co(III)–OClO−. Its UV–Vis spectrum is almost identical to that of aquaCbl, except for some minor differences at ~ 430 nm; cyanide can eliminate and prevent these changes. The 1H-NMR spectra reveal strong influences of chlorite on the B2 and B4 protons of the cobalt-bound dimethyl benzimidazole ligand. Together, the UV–Vis and NMR titrations suggest a Kd of 10 mM or higher for chlorite on Cbl. Resonance Raman spectra reveal minor changes in the spectrum of aquaCbl to chlorite—as well as a disappearance of the free chlorite signals, consistent with Cbl–chlorite complex formation. Corroboration for these interpretations is also offered from mass spectrometry and DFT calculations. This Co(III)–OClO− complex would be a stable analogue of the first reaction intermediate in the catalytic cycle of chlorite dismutase, or in the reaction of chlorite with a number of other heme proteins. The differences in reactivity between Co(III) cobalamin and Fe(III) heme towards chlorite are analyzed and rationalized, leading to a reconciliation of experimental and computational data for the latter.
Tailoring mesoporous ferrocene-modified activated carbon for phenol removal in wastewater
Authors: Mqehe-Nedzivhe Khathutshelo C. , Ojo Babatope O. , Mabuba Nonhlangabezo 
Published: February 2025

Abstract
This study investigates the adsorption capacity (qmax) of synthesized ferrocene-modified activated carbon (AC-H3PO4/Fe7S8) for the removal of phenol in wastewater. The structural and morphological features of the synthesized composite were determined using FTIR, BET, XRD, and SEM. With an average pore size of 59.127 nm, AC-H3PO4/Fe7S8 composite achieved 98% removal efficiency of phenol at optimal conditions comprising adsorbent dosage of 0.3 g, contact time of 120 min, pH of 4, and concentration of 50 mg/L. The Freundlich isotherm model displayed R² values of 0.9965 and 0.9955, while the evaluated maximum adsorption capacities were 9.15 and 13.32 mg/g for AC-H3PO4 and AC-H3PO4/Fe7S8 respectively. The adsorption kinetics was also fitted into a Pseudo second-order kinetic model with a rate constant of 0.10462 min−1 at optimal conditions. The thermodynamics parameters suggested that the reaction was spontaneous and endothermic with increased randomness. The findings describe the synthesized AC-H3PO4/Fe7S8 composite as a promising adsorbent for the removal of phenol wastewater treatment.
Cell death signaling in human erythron: erythrocytes lose the complexity of cell death machinery upon maturation
Authors: Tkachenko Anton , Havranek Ondrej 
Published: February 2025

Abstract
Over the recent years, our understanding of the cell death machinery of mature erythrocytes has been greatly expanded. It resulted in the discovery of several regulated cell death (RCD) pathways in red blood cells. Apoptosis (eryptosis) and necroptosis of erythrocytes share certain features with their counterparts in nucleated cells, but they are also critically different in particular details. In this review article, we summarize the cell death subroutines in the erythroid precursors (apoptosis, necroptosis, and ferroptosis) in comparison to mature erythrocytes (eryptosis and erythronecroptosis) to highlight the consequences of organelle clearance and associated loss of multiple components of the cell death machinery upon erythrocyte maturation. Recent advances in understanding the role of erythrocyte RCDs in health and disease have expanded potential clinical applications of these lethal subroutines, emphasizing their contribution to the development of anemia, microthrombosis, and endothelial dysfunction, as well as their role as diagnostic biomarkers and markers of erythrocyte storage-induced lesions. Fas signaling and the functional caspase-8/caspase-3 system are not indispensable for eryptosis, but might be retained in mature erythrocytes to mediate the crosstalk between both erythrocyte-associated RCDs. The ability of erythrocytes to switch between eryptosis and necroptosis suggests that their cell death is not a simple unregulated mechanical disintegration, but a tightly controlled process. This allows investigation of eventual pharmacological interventions aimed at individual cell death subroutines of erythrocytes.
Developing a Low-Resource, Evidence-Based Early Years Professional Development Programme Using Self-Assessment
Authors: Mazhar Anushay , Sylva Kathy 
Published: February 2025

Abstract
Early language and communication skills are critical for children’s development and early years educators are well-placed to support children’s learning; however, many early years educators receive little training to support the development of these skills. While professional development programmes offer a potential solution, existing programmes have yielded mixed findings, and little is known about why this is the case since most programmes do not describe their intended mechanisms of change. Moreover, most programmes require abundant resources, leading to limited sustainability and scalability. This paper presents a theoretical framework for a low-resource professional development programme aimed at enhancing educators’ abilities to support preschool children’s language and communication skills. We identify core characteristics (sustained, multi-format, flexible, context-sensitive, focused) and active components (coaching, practice, feedback, reflection, goal setting, modelling, group engagement) of effective professional development programmes, which we use to inform the programme design. The proposed programme integrates three main components: (1) LangQuest, a free, downloadable self-assessment tool designed to help educators reflect on their language-supporting strategies, (2) an online course that promotes meaningful use of the LangQuest and builds educators’ knowledge of how and when to use different pedagogical strategies, and (3) Learning Circles, a form of professional learning communities to promote social learning. We envision that this programme will enhance educators’ procedural knowledge of language-supporting strategies and improve teacher-child interactions, ultimately fostering children’s language and communication skills. By identifying features of effective early years programmes, the paper provides a practical roadmap to those interested in developing PD programmes or integrating the LangQuest into existing programmes.
Exploring the Impact of Generative AI on Peer Review: Insights from Journal Reviewers
Authors: Ebadi Saman , Nejadghanbar Hassan , Salman Ahmed Rawdhan , Khosravi Hassan 
Published: February 2025

Abstract
This study investigates the perspectives of 12 journal reviewers from diverse academic disciplines on using large language models (LLMs) in the peer review process. We identified key themes regarding integrating LLMs through qualitative data analysis of verbatim responses to an open-ended questionnaire. Reviewers noted that LLMs can automate tasks such as preliminary screening, plagiarism detection, and language verification, thereby reducing workload and enhancing consistency in applying review standards. However, significant ethical concerns were raised, including potential biases, lack of transparency, and risks to privacy and confidentiality. Reviewers emphasized that LLMs should not replace human judgment but rather complement it with human oversight, which is essential to ensure the relevance and accuracy of AI-generated feedback. This study underscores the need for clear guidelines and policies, as well as their proper dissemination among researchers, to address the ethical and practical challenges of using LLMs in academic publishing.
Adolescent Fathers’ Experiences: A Qualitative Study
Authors: Erbay Elif , Tecik Seda , Menekse Dilek , Cinar Nursan 
Published: February 2025

Abstract
The existing body of literature concerning adolescent fathers is notably limited. This study aims to meticulously explore the fatherhood experiences of individuals who assumed the role during their adolescence. The qualitative data for this phenomenological study were collected online between March and August 2022. The study was conducted with participants residing in four different geographical regions in Turkey (Marmara, Eastern Anatolia, Southeastern Anatolia and Central Anatolia regions). The study cohort comprised eleven fathers, aged between 20 and 25 years. Data were gathered utilizing a questionnaire and a semi-structured interview form. Following the thematic analysis, we developed five overarching themes: “Emotions and experiences of being a father”, “Increased need for social support”, “Lifestyle changes due to being an adolescent father”, “Positive and negative effects of being an adolescent father” and “Recommendations for those who consider early marriage and becoming a father”. The study illuminated that those who became fathers during adolescence encountered financial challenges, mitigated by support from their immediate family or experienced relatives engaged in childcare. The findings of this study are anticipated to furnish essential data for nurses working with adolescents, contributing to the safeguarding and enhancement of adolescent health.
The impact of experiential avoidance on anxiety and depressive disorders in hematological cancer patients
Authors: Weißflog Gregor , Ernst Jochen , Esser Peter , Platzbecker Uwe , Vucinic Vladan , Mehnert-Theuerkauf Anja , Springer Franziska 
Published: February 2025

Abstract
Anxiety disorders and/or depressive disorders co-occurring with hematological cancer are an additional burden for patients. Experiential avoidance (EA; efforts to avoid negative emotions, thoughts, or memories) is an empirically evident transdiagnostic factor for the onset and maintenance of anxiety and depressive disorders in non-cancer populations. There is lack of evidence on the impact of EA in predicting anxiety and depression in cancer patients. A total of 291 patients with hematological cancer (60% male, mean age 55 years) were included in this cross-sectional observational study. Participants were assessed using the Structured Clinical Interview for DSM-5 mental disorders (SCID-5). EA was assessed via self-report using the Brief Experiential Avoidance Questionnaire (BEAQ). Hierarchical binomial logistic regression was conducted in order to estimate the impact of EA on anxiety and depressive disorders. A total of 38 patients (13.3%) met the diagnostic criteria for a current anxiety disorder, while 49 patients (17.2%) met the criteria for a current depressive disorder. In bivariate analyses, EA was significantly elevated in patients with an anxiety disorder in comparison to those without (54.4 vs. 48.9; p = 0.01). The same was true for depressive disorder (54.9 vs. 48.6; p < 0.01). After controlling for relevant sociodemographic and medical factors, EA did not predict anxiety or depressive disorder in separate regression models. The presence of an anxiety disorder was significantly predicted by female sex, younger age and elevated comorbidity burden. In contrast, the presence of a depressive disorder was predicted by comorbidity burden. Sociodemographic and medical predictors have greater predictive potential than EA regarding current anxiety and depressive disorder in hematological cancer patients.
Knowledge of PrEP Among Healthcare Workers in Substance Use Disorder Services: A Cross-Sectional Study in Italy
Authors: Moro Giuseppina Lo , Rosset Lorenzo , Varì Maria Grazia , Lucchini Alfio , Balestra Roberta , Scaioli Giacomo , Siliquini Roberta , Bert Fabrizio 
Published: February 2025

Abstract
Pre-exposure prophylaxis (PrEP) is an evidence-based strategy for HIV prevention, particularly for high-risk populations such as people who inject drugs and engage in chemsex. In Italy, there is no data on the actual knowledge of PrEP among Healthcare professionals (HCPs) in substance use disorder services (SerDs). This study aimed to assess PrEP awareness among SerD HCPs, also exploring their level of knowledge, practice, training, and perceived barriers. A cross-sectional study was conducted using a convenience sample of HCPs from SerDs across Italy (2023–2024). The questionnaire addressed sociodemographic and work-related information, PrEP awareness, knowledge scores (i.e. percentage of correct answers) on when proposing PrEP and reimbursement criteria, practice, and training received. Multiple logistic regression was performed to explore associations with PrEP awareness. The sample consisted of 306 professionals (26.8% physicians). Only 44.8% were aware of PrEP, with lower awareness among non-physicians (p < 0.001). As for knowledge scores on when proposing PrEP and on reimbursement, the median was 57.14% (IQR: 42.86–71.43%) and 55.56% (IQR: 33.33–66.67%), respectively. No differences were reported across professional roles. Only 10.36% reported PrEP is offered at their workplace and 87.9% highlighted a lack of training. Additionally, 96.79% believed it would be appropriate for HCPs to receive PrEP training; however, nurses were the most likely to state it is not appropriate (p = 0.046). The study identified gaps in PrEP knowledge and training among SerD professionals, including physicians. The strong interest in training suggests that SerD HCPs, though with varying perceptions, may be a receptive group for interventions for improving PrEP implementation.
Troublesome Bodies: How Bodies Come to Matter and Intrude in Eating Disorder Recovery
Authors: Holen Mari , Ringer Agnes , Steno Anne Mia 
Published: February 2025

Abstract
Understanding how bodies come to matter in eating disorder recovery is complex, particularly given the unresolved question of whether eating disorders are fundamentally about the body. Drawing on Analu Verbin’s adaptation of Judith Butler’s theory of performativity and Sarah Ahmed’s body phenomenology, this paper examines how participants in a narrative and systemic group therapy program at a mental health clinic for eating disorders perceive themselves as recovering or recovered. We explore how the body is presented and understood in their recovery narratives, developing the concept of the ‘troublesome body’ to highlight the ambiguities these narratives reveal. The body in the participants’ narratives is continuously shaped by an external gaze that alternates between recognition and concern, often oscillating between praise and scrutiny. Participants are tasked with cultivating a liberated, sensual body and a more natural relationship with food, achieved through therapeutic strategies such as establishing a mechanical eating pattern and ‘neutralizing’ the body in group settings. Yet the body resists, asserting its presence through physical sensations—rumbling stomachs and ‘blobby’ forms—that challenge these efforts. Crucially, the narrative and systemic group therapy is viewed by participants as pivotal in their recovery not because it resolves all eating disorder-related issues, but because it offers a collective space for ‘troublesome bodies.’ This space allows for bodies to exist without conforming to societal dichotomies or norms that are often imposed in other treatment contexts, thus, offering an alternative model of recovery where bodily ambiguities can be embraced rather than resolved.
History of Alcohol Use Disorder and Housing Instability as Predictors of Fatigue and Mental Health Problems During the COVID-19 Pandemic
Authors: Leiter Noa , Luk Jeremy W. , Stangl Bethany L. , Gunawan Tommy , Schwandt Melanie L. , Goldman David , Diazgranados Nancy , Ramchandani Vijay A. 
Published: February 2025

Abstract
Mental health and alcohol problems are significant public health concerns amid the COVID-19 pandemic. Housing instability and symptoms of fatigue are understudied aspects of the pandemic. This study examined history of Alcohol Use Disorder (AUD), history of COVID-19 infection, and housing instability as correlates of fatigue, anxiety, and depression symptoms. Data were drawn from 250 adults enrolled in an online survey within the NIAAA COVID-19 Pandemic Impact on Alcohol Study in between April 6 and June 2 of 2022. Participants completed self-report measures of housing stability, fatigue, and mental health symptoms. Multivariable analyses controlling for age, sex, race, ethnicity, and household income were conducted. Individuals with a history of AUD reported higher mental fatigue, anxiety symptoms, and depressive symptoms when compared to those with no history of AUD. Individuals with “other” housing arrangements (not renting or owning) reported higher mental fatigue, pandemic fatigue, anxiety symptoms, and depressive symptoms relative to homeowners. Individuals who worried about not having a place to live in the past 6 months reported higher physical fatigue, mental fatigue, anxiety symptoms, and depressive symptoms when compared to individuals without housing worry. History of COVID-19 infection was neither associated with mental health nor fatigue symptoms. Housing instability, as captured by housing worry and having “other” housing arrangements, was associated with greater fatigue and mental health problems, even after controlling for household income. Housing instability uniquely contributed to mental health symptoms, warranting further research and targeted prevention and intervention efforts.
Call center data analysis and model validation
Authors: Koole Ger , Li Siqiao , Ding Sihan 
Published: February 2025

Abstract
We analyze call center data on factors such as agent heterogeneity, customer patience and agent breaks. Based on this, we construct different simulation models and compare their performance with the actual realized performance. We classify them according to the extent in which they accurately approximate the service level and average waiting times. We also obtain a theoretical understanding on how to distinguish between the model error and other aspects such as random noise. We conclude that modeling explicitly breaks and agent heterogeneity is crucial for obtaining a precise model.
VolRec: 4D real-time volumetric reconstruction of OCT data
Authors: Vicente-Jaén Arturo , Mompeán Juan , Aragón Juan L. , Artal Pablo 
Published: February 2025

Abstract
This work presents the design, analysis and development of VolRec, a volumetric 4D reconstruction system for OCT (optical coherence tomography) data. VolRec is able to obtain and process more than 25 high-resolution OCT data volumes per second. This way, VolRec allows OCT systems to perform real-time measurements that could help doctors and physicians in many different cases, e.g., during surgical interventions or during exams to restless patients, such as kids. Moreover, VolRec allows to adapt to telemedicine techniques such as telesurgery or image-guided medical robots. To achieve real-time performance, it is necessary to address the limitations of current OCT systems, which are restricted by both the acquisition and processing of massive amounts of data. To overcome those limitations, this work proposes an approach based on a 4D reconstruction. Our proposal allows to generate high-resolution volumes from acquired low-resolution ones. Hence, increasing the acquisition speed while reducing the acquisition resolution without sacrificing image quality. To this end, we use parallel programming mechanisms such as OpenMP (for CPUs) and CUDA to exploit the computing capabilities of modern GPUs. Our real-time volumetric reconstruction algorithm efficiently achieves a very high performance, reaching a processing rate of 18 GigaVoxels/s and about 72

$$\times$$

×

speedup over a parallel CPU-based algorithm using a GPU, by efficiently exploiting the vast amount of data-level parallelism inherent to OCT data volumes.