bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epithelioid hemangioendothelioma: Report of a case diagnosed by fine‐needle aspiration
Authors: Gambacorta Marcello , Bonacina Edgardo 
Published: February 2007

AbstractA case of epithelioid hemangioendothelioma suggested by fine‐needle aspiration biopsy is reported. The clinical, cytological, histopathological, and postmortem findings are described. The diagnosis was confirmed by cyto‐histoimmunochemical studies.
Male breast lesions: Gynecomastia and its distinction from carcinoma by aspiration biopsy cytology
Authors: Russin Victoria L. , Lachowicz Carolyn , Kline Tilde S. 
Published: February 2007

AbstractGynecomastia is a benign proliferative lesion of the male breast. It may present as a diffuse bilateral process or a unilateral, discrete mass, clinically suggestive of carcinoma. We examined the aspiration biopsy cytology of 50 cases of gynecomastia to define the cytologic criteria and to distinguish it from carcinoma. The parameters of cellularity, architecture, single columnar cells, naked nuclei, nuclear and cell size, nuclear and cytoplasmic characteristics, and extraneous cells were accessed. Diagnostic confusion with carcinoma may occur because of cellularity with loose groups and single cells; however, the mixed cell population, composed of cohesive sheets or groups of bland cells, bipolar naked nuclei, and single tall columnar cells, delineates gynecomastia from carcinoma of the male breast.
Aspiration cytology of Wilms' tumor: Correlation of cytologic and histologic features
Authors: Akhtar Mohammed , Ali Mohammed Ashraf , Sackey Kwesi , Sabbah Rajeh , Burgess Annie 
Published: February 2007

AbstractWe examined the cytomorphologic features of fine‐needle aspiration biopsy (FNAB) specimens from 23 Wilms' tumor patients. The findings were correlated with histopathologic patterns from these tumors. The study revealed a close resemblance between the cytologic and histopathologic appearance of various cellular elements in Wilms' tumors. The major cellular patterns seen in Wilms' tumor include blastemal cells, blastemal cells with epithelial differentiation, blastemal cells with tubular differentiation, and stromal elements. It is hoped that recognition of these cellular components in aspiration smears will be helpful in establishing an FNAB diagnosis of Wilms' tumor.
Human papovavirus in a routine urine specimen of a four‐year‐old boy
Authors: Braza Frank , Johnson Kathleen A. , Grigg Lois M. , Lopez Victor F. , Kavirajan Vadakkekara 
Published: February 2007

AbstractCellular changes produced by viruses can be readily identified using light microscopy and Papanicolaou stain of a fixed specimen. These findings can then be confirmed by viral culture and/or electron microscopy studies. Human polyomavirus, common in transplant recipients or otherwise immunocompromised patients, is one virus that can be identified using these methods. The following is a case study of a 4‐yr‐old boy with no known immune impairment who exhibited human papovavirus (polyomavirus) on a routine urine examination. The diagnosis was confirmed by electron microscopy.
Fine‐needle aspiration of subcutaneous phaeohyphomycosis caused by Wangiella dermatitidis
Authors: Crosby John H. , O'Quinn Mary H. , Steele John C. H. , Rao R. N. 
Published: February 2007

AbstractTwo cases of subcutaneous phaeohyphomycosis, first recognized by fine‐needle aspiration (FNA), were confirmed with culture, excision, and histologic study. Both patients had debilitating medical problems and a solitary mass on the left leg. Pigmented hyphae and other fungal elements, numerous in both aspirates, assumed a variety of forms that did not permit specific identification. Culture grew Wangiella dermatitidis in both cases. FNA also yielded purulent exudate, multinucleated giant cells, and, in one case, epithelioid histiocytes. Both excised lesions were abscesses, with associated granulomatous inflammation, fibrosis, and plant splinters. Fungi in sections resembled those seen in the aspirates.
Adrenal myelolipoma: Preoperative diagnosis by fine‐needle aspiration cytology
Authors: Katsuta Koji , Nakabayashi Hiroshi , Kuroda Yuzuru , Liu Paul I. 
Published: February 2007

AbstractFine‐needle aspiration (FNA) was performed under ultrasonographic guidance on a suprarenal mass in a 52‐yr‐old Japanese man. Preoperatively, the diagnosis of adrenal myelolipoma was easily established from the cytologic findings of the aspirates. FNA is a very useful technique for the differential diagnosis of this tumor, and it is particularly valuable for many hospitals that are not equipped with computed tomography.
Variations in interpretation of gynecologic cytology photomicrographs
Authors: Maguire Nancy Council 
Published: February 2007

AbstractThis was a study of variations in interpretations of photomicrographs of gynecologic cytology specimens. Two photomicrographs from each of 20 gynecologic cytology specimens were examined by 10 cytotechnologists and 10 pathologists. In only two cases was there agreement among all participants regarding the primary entity illustrated. The greatest agreement in interpretation was for benign entities such as repair reaction, koilocytotic changes, benign endocervical cells, and herpes simplex. There was little uniformity in the recognition of intraepithelial neoplasia and invasive carcinoma, or these lesions are difficult to illustrate using photomicrographs. Most abnormal cases were identified at least as atypical, but in many cases the range of responses was great—for example, atypical squamous metaplasia to squamous carcinoma. There was more uniformity among cytotechnologists than pathologists in the recognition of the cytologic entities presented. The results of this study illustrate the difficulty of selecting photomicrographs for testing purposes and the lack of uniformity in the interpretation of such photomicrographs.
Cytology of primary versus secondary genital herpesvirus infection
Authors: Naib Zuher M. , McNeill William F. , Crowder Susan , Fekete Paul 
Published: February 2007

AbstractCertain authors state that primary genital herpes infections mainly produce cells with ground‐glass nuclei, whereas secondary infections produce a higher percentage of multinucleated or single cells with prominent intranuclear inclusions. The cervicovaginal smears of 11 patients with primary genital herpes infection and 16 patients with secondary infection were studied to determine the validity of this differentiation. The percentage per patient of virally infected cells containing distinct inclusions ranged from 0% to 35% in the primary herpes group and 0% to 100% in the secondary herpes group. In eight additional patients, the initial herpes simplex virus (HSV)‐positive smear was compared with recurrent positive smears taken from 2 to 120 mo later. No statistical difference in the incidence of distinct inclusions in the infected cells was detected. Finally, primary rabbit kidney and the heteroploid A549 cell cultures were inoculated with herpes viruses and followed by fixation with several agents at various time intervals. Alcohol and Bouin's fixative favored the recognition of distinct inclusions, as did the duration of the infection.
Lymphocytic thyroiditis in fine‐needle aspirates: Differential diagnostic aspects
Authors: Tseleni‐Balafouta Sofia , Kyroudi‐Voulgari Aspasia , Paizi‐Biza Penelopi , Papacharalampous N. X. 
Published: February 2007

AbstractThis study assessed the morphological criteria for the diagnosis of various types of lymphocytic thyroiditis in fine‐needle aspirates. Of 950 aspirates, 121 revealed lymphocytic thyroiditis, including Hashimoto's thyroiditis (partly confirmed by serological or histological examination) and focal thyroiditis adjacent to neoplasms. The diagnosis of Hashimoto's thyroiditis was easy when the aspirated material was adequate and contained oxyphilic cells: in the fibrous type, diagnosis was rather dificult. Focal thyroiditis may be confused with Hashimoto's thyroiditis, especially when adjacent to neoplasm. Surgical exploration should be performed in cases of severe lymphocytic thyroiditis revealed by fine‐needle aspiration with repeatedly negative antibody titers in order to exclude neoplasm.
Role of fine‐needle aspiration cytology in childhood malignancies
Authors: Rajwanshi A. , Rao K. L. N. , Marwaha R. K. , Nijhawan V. S. , Gupta S. K. 
Published: February 2007

AbstractDuring the last 4 yr. fine‐needle aspiration cytology (FNAC) has been employed in 1,474 patients in 0‐15‐yr age group at our institute. Of these, 245 patients were found to have malignant disease, including primitive neuroectodermal tumors, hepatoblastoma, nephroblastoma, sarcoma, and epithelial malignancies. Four metastases from medulloblastoma and two each from astrocytoma and meningioma were confirmed without open biopsy. FNAC interpretation was easy when cytologic findings were correlated with relevant clinical and radiologic data.
Significance of giant cells in fine‐needle aspiration biopsies of benign and malignant lesions of the pancreas
Authors: Silverman Jan F. , Finley James L. , Berns Lisa , Unverferth Marsha 
Published: February 2007

AbstractThe cytologic results of 44 consecutive fine‐needle aspiration (FNA) biopsies of the pancreas are reported. The series consisted of 27 women and 17 men with an age range of 31–89 yr (mean, 61.5), Excluding insufficient cases, the sensitivity of the procedure was 88%. specificity was 100%, positive predicative value (PV) was 100%, negative PV was 69%, and efficiency of the test was 90%, There were 29 true‐positive, four false‐negative, and nine true‐negative diagnoses. Two specimens were insuficient for diagnosis. Giant cells of varying types were seen in both the malignant and benign cases. Two of the benign cases demonstrated rare multinucleated foreign body‐type giant cells, most likely representing the changes seen in pancreatitis. In 13 malignant cases, multinucleated tumor cells were present, while six additional cases had multinucleated benign histioeytes reflecting the associated pancreatitis. Two malignant cases each had tumor giant cells and benign multinucleated histiocytes. Three of the malignant cases had numerous multinucleated tumor giant cells arranged in a dissociative fashion with evidence of cytophagocytosis consistent with a pleomorphic giant‐cell carcinoma of the pancreas. One additional case demonstrated numerous multinucleated osteoclastic‐like cells consistent with an osteoclastic tumor of the pancreas. This article documents the accuracy of FNA biopsy of the pancreas and notes that giant cells of varying types can be found in pancreatic FNA biopsies. Appreciation of the various types of giant cells in pancreatic FNA biopsy is important for diagnostic accuracy and prognosis.
Transthoracic needle aspiration biopsy in inflammatory pseudotumors of the lung
Authors: MacHicao Carlos N. , Sorensen Kelly , Abdul‐Karim Fadi W. , Somrak Theresa M. 
Published: February 2007

AbstractThe cytologic findings on transthoracic needle aspiration biopsy in four patients with pulmonary inflammatory pseudotumor are described. These findings have not been previously illustrated in the literature. The main cytologic components of this lesion are histiocytes, lymphocytes, fibroblasts, pneumocytes, and plasma cells. Familiarity with these features is essential to avoid misdiagnosis and possible overtreatment.
Morphometric analysis of hyperthermia‐induced nuclear and nucleolar size modifications in a human melanoma cell line
Authors: Delpino Andrea , De Santis Maurizio , Sudano Luigi , Donnorso Raffaele Perrone , Ferrini Umberto 
Published: February 2007

AbstractAlthough no prominent morphologic alterations were observed by light microscopy in a human melanoma cell line (M‐14) exposed at 42°C for 4 hr. the computerized image analysis demonstrated a significant enlargement of both nuclei and nucleoli. The mean nuclear and nucleolar areas were found to be 32% and 94% increased, respectively, in comparison with normal controls. The gaussian distribution of absolute frequency of the measures demonstrated that this nuclear and nucleolar enlargement was distributed among the whole cell population, taking place in clonogenic cells and in “sterilized” cells, ultimately doomed to die. This finding, not previously described in the context of the heat shock response, may be regarded as morphological evidence of an increase in the protein content of the nuclei of heat‐treated cells, as determined by biochemical methods.
Tissue imprints in surgical pathology: A rapid intraoperative diagnostic aid
Authors: Scopa Chrisoula D. , Melachrinou Maria , Apessou Demetra , Bonikos Dionysis 
Published: February 2007

AbstractWe studied the intraoperative diagnostic value of imprint cytology in 230 samples obtained from surgical specimens submitted for frozen section diagnosis. A rapid hematoxylineosin stain was used. Intraoperative imprint cytology achieved an accuracy rate of 94.3%; for benign lesions the accuracy was 97.5%, and for malignant lesions it was 91%. Overall, the false‐negative and suspicious‐for‐malignancy rates were 1.3% and 4.3%, respectively. No false‐positive results were found. The diagnostic yield when intraoperative imprint cytology and frozen section were used together was 99%. It is apparent that imprint cytology is a quick and simple method with wide applicability in the histopathologic diagnosis of lesions from all organs. The value of the method is enhanced when it is used with frozen section diagnosis.
Light and electron microscopic examination of fine‐needle aspirates in the preoperative diagnosis of osteogenic tumors: A study of 21 osteosarcomas and two osteoblastomas
Authors: Walaas Lisa , Kindblom Lars‐Gunnar 
Published: February 2007

AbstractTwenty‐three patients with primary osteogenic tumors, two osteoblastomas and 21 osteosarcomas, underwent fine‐needle aspiration biopsy in the preoperative investigation. The cytologic features in smears were compared with the light and electron microscopic findings of resin‐embedded fine‐needle aspirates (16 cases) and the histopathologic findings of the surgical specimens. Cytologic smears clearly indicated a primary bone malignancy in all 20 high‐malignancy osteosarcomas. In the osteoblastic osteosarcomas, the diagnosis of osteosarcoma was strongly suggested by the osteoblastic appearance of the tumor cells and the presence of an osteoid‐like fibrillar matrix in 6 of 11 cases in the May‐Grünwald‐Giemsa‐stained smears. The distinction of chondroblastic osteosarcomas from high‐grade chondrosarcomas and of polymorphic osteosarcomas from malignant fibrous histiocytomas is difficult in smears. Electron microscopic examination and immunocytochemistry indicating a positivity for vimentin but not for cytokeratin helped to exclude the possibility of a carcinoma in osteoblastic osteosarcomas where the tumor cells had epithelium‐like features in the smears. The resin‐embedding technique of fine‐needle aspirates was useful for the typing since it gave additional light microscopic information about growth pattern, structure, and matrix production, as well as ultrastructural information about cell and tissue differentiation. The osteoid‐like material seen in May‐Grünwald‐Giemsa‐stained smears could be proven to represent osteoid with varying degrees of calcification at the ultrastructural examination. The fine‐needle aspiration technique, especially when used for both smears and embedding, may play an important role in the preoperative investigation of bone tumors, provided that it is used with full knowledge of the clinical and radiographic findings.
Neuroendocrine (merkel‐cell) carcinoma of the skin: Immunocytochemical and cytomorphologic analysis on fine‐needle aspirates
Authors: Skoog Lambert , Schmitt Fernando C. , Tani Edneia 
Published: February 2007

AbstractCytomorphologic and immunocytochemical characteristics of tumor cells from fine‐needle aspirates of four neuroendocrine (Merkel‐cell) carcinomas of the skin are described. All aspirates were cellular with dispersed small to medium sized tumor cells with scanty cytoplasm. Many mitoses were observed. Careful scrutiny revealed a tendency of the tumor cells to form microacinar and pseudorosette formations as well as small clusters of molding cells. Immunocytochemical analysis of cytospin preparations showed a peculiar dot‐like cytokeratin positivity, while neuron‐specific enolase staining was more diffuse. A weak S‐100 positivity was observed. This staining pattern is highly suggestive of Merkel‐cell tumor. It can thus be concluded that immunocytochemical analysis in conjunction with cytomorphology on fine‐needle aspirates will allow the identification of neuroendocrine carcinoma of the skin and its differentiation from other small‐cell neoplasias of the skin.
Metaplastic carcinoma of the breast—diagnosis by aspiration biopsy cytology: Report of two cases and literature review
Authors: Kline Tilde S. , Kline Irwin K. 
Published: February 2007

AbstractThe unusual metaplastic carcinomas have a variety of names, each emphasizing the dominant histologic pattern. Components may include features of ductal, spindle, or squamous carcinoma with pseudosarcomatous, cartilaginous, or boney areas. A few reports from individual tumors examined by fine‐needle aspiration biopsy have emphasized an array of findings. This study includes two of our cases with a review of 12 others from the literature. The breast neoplasm has a characteristic pattern on aspiration biopsy cytology (ABC). The cell‐rich aspirate reveals benign multinucleated giant cells intermingled with malignant spindled or squamous cells on a background of necrotic debris, inflammatory cells, and blood. Additionally, cells from infiltrating ductal carcinoma and mesenchymal fragments are often seen.
Aspiration biopsy cytology of the prostate in young adult men
Authors: Howell Lydia Pleotis , Amott Thomas R. , De Vere‐White Ralph 
Published: February 2007

AbstractThe aspiration biopsy cytology of 11 prostates obtained at autopsy from men younger than 40 yr old were studied to define the cytologic criteria of benign changes in this age group. Cytologic features that differ from those of older men with benign prostatic enlargement include abundant cellularity, the presence of large and small cell groups (which would otherwise suggest dyshesion), and a predominantly columnar cell shape. These differences can be attributed to age‐related changes in the prostate. A case of a prostatic nodule in a 22‐yr‐old that was evaluated by fine‐needle aspiration biopsy is presented to illustrate the diagnostic difficulties that can arise when the interpreter is unaware of differences in cytologic patterns due to age.
Immunocytochemical analysis of receptors for estrogen and progesterone in fine‐needle aspirates from human breast carcinomas
Authors: Skoog Lambert , Humla Solveig , Isaksson Saed , Tani Edneia 
Published: February 2007

AbstractMonoclonal antibodies were used for a preoperative analysis of estrogen receptors (ERs) and progesterone receptors (PgRs) in fine‐needle aspirates from 44 primary human breast carcinomas. The semiquantitative receptor values obtained in cytologic specimens correlated well with those from enzyme immunoassay analysis on surgically removed tumor tissue (r = 0.74 for PgR;r = 0.75 for ER). Cytologic smears showed a heterogenous tumor cell distribution of ER and PgR in 29 and 23 cases, respectively. The results suggest that measurement of the ER and PgR in cytologic smears is an accurate and reliable technique that can be performed on a minimum amount of tissue.
Fine‐needle aspiration biopsy of seminoma and dysgerminoma: Cytologic, histologic, and electron microscopic correlations
Authors: Akhtar Mohammed , Ashraf Ali M. , Huq Mahmuda , Bakry Mohammed 
Published: February 2007

AbstractCytomorphologic features in a series of fine‐needle aspiration biopsies from eight patients with seminoma or dysgerminoma were reviewed, and the findings were further correlated with histopathologic and ultrastructural appearances. Three cell types were encountered. Type I was least differentiated and least frequent. Type II was most frequent and had well‐developed cytoplasm rich in organelles. Type III was similar to type II but also contained abundant cytoplasmic glycogen. In cytology smears, type III cells contained large punched‐out cytoplasmic vacuoles corresponding to the areas of glycogen deposition. The background contained a variable mixture of inflammatory cells including lymphocytes, plasma cells, epithelioid cells, and epithelioid granulomas. The significance of these findings in the diagnosis of seminoma or dysgerminoma and the distinction from other germ‐cell and non‐germ‐cell tumors is briefly discussed.
Fine‐needle aspiration biopsy of mucus‐producing medullary carcinoma of thyroid: Report of a case with cytologic, histologic, and ultrastructural correlations
Authors: Haleem Abdul , Akhtar Mohammed , Ali Muhammad Ashraf , Iqbal Zafar 
Published: February 2007

AbstractCytologic features of aspiration smears from a mucus‐producing medullary carcinoma of the thyroid are described. Two patterns of mucin production by the tumor cells were noted. In some cells, mucin was present as numerous small cytoplasmic vacuoles with ultrastructural morphology characteristic of mucin granules. Other cells had larger, more well‐defined cytoplasmic mucin vacuoles; on ultrastructural examination, they were found to be intracytoplasmic lumina. Although mucin production has been demonstrated in several histologic studies of medullary carcinoma, it has not been previously recognized in fine‐needle aspiration biopsies from this neoplasm.
Negative images of bacilli and mycobacterial infection: A study of fine‐needle aspiration smears from lymph nodes in patients with aids
Authors: Stanley Michael W. , Horwitz Charles A. , Burton Linda G. , Weisser John A. 
Published: February 2007

AbstractIn patients with the acquired immunodeficiency syndrome (AIDS), four cases of mycobacterial infection in which bacilli appeared as cylindrical, nonstaining ‘negative images’ have been previously described. These may have been extracellular or within histiocyte cytoplasm, and they have been described in aspirations from liver, lymph node, and bone marrow and in bronchoalveolar lavage fluid. We report three additional examples of this finding in fine‐needle aspirations from lymph nodes in AIDS patients infected with Mycobacterium avium‐intracel‐lulare. Our findings support the concept that these negative images of bacilli are diagnostic of mycobacterial infection. Air‐dried Romanovsky‐stained material is requires for their identification.
Urinary sediment in storage diseases: Differential diagnosis of nieman‐pick disease by cytologic means
Authors: Sane Sudha Y. 
Published: February 2007

AbstractRenal involvement in lipid storage diseases is well recognized. Electron microscopy or chemical analysis of urinary sediment has been used for the diagnosis of these diseases. Urine cytology, supplemented by cytochemistry, polarization, and autofluorescence, helped us in the diagnosis of Niemann‐Pick disease in an infant. The unique findings are described, and the differential diagnosis of storage cells by cytochemical stains is discussed.
Fine‐needle aspiration cytology diagnosis of a symptomatic bony metastasis from an occult hepatocellular carcinoma: A case report
Authors: Ng Irene O. L. , Leung C. Y. , Ho J. W. C. 
Published: February 2007

AbstractFine‐needle aspiration cytology is widely used for rapid diagnosis. We here report a case in which aspiration of a mass in the left posterior aspect of the chest wall in an elderly patient revealed metastasis from a clinically unrecognized hepatocellular carcinoma. Diagnostic features of the tumor are discussed.