bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global, regional and national burdens of reproduction-related congenital birth defects, 1990–2019
Authors: Shen Lin , Li Jie , Zhang Hanwang , Zhao Yiqing 
Published: February 2024

BackgroundReproduction-related congenital birth defects (RCBDs), including Klinefelter syndrome (KS), Turner syndrome (TS), and urogenital congenital anomalies (UCA), can lead to severe physical and psychosocial disorders. The global impact of RCBDs on children and adults is unknown, which limits high-quality development of populations and increases in life expectancy per capita.MethodsAnnual incidence rates, prevalence rates (PR), and disability-adjusted life year (DALY) rates were collected for KS, TS, and UCA for 204 countries and territories, including at birth, for children younger than 1 year, and age-standardized (AS) for all ages. Linear regression was used to calculate their estimated annual percentage changes (EAPCs). Finally, the relationships between EAPCs of each indicator and sociodemographic index (SDI) was investigated using Pearson correlation analysis.ResultsGlobally, the age-standardized prevalence rate (ASPR) trend is decreasing in KS and TS and increasing in UCA. The DALY rates for children younger than 1 year were on a downward trend in KS and UCA, while they were still rising for TS. The AS-DALY rates were all on a downward trend in KS, TS, and UCA. The DALY rates of KS, TS and UCA were found higher in high-income countries in North America. In addition, the burdens of TS and UCA went down with increasing SDI, whereas the burden of KS increased with increasing SDI.ConclusionThe global burdens of RCBDs have decreased since 1990. This finding can help policymakers implement cost-effective interventions to reduce the burdens of RCBDs.
Utilization of the Intimacy and Sexuality Expression Preference tool in long-term care: a case study
Authors: Jones Cindy , Moyle Wendy , Van Haitsma Kimberly , Hudson Carly 
Published: February 2024

IntroductionSexual wellness plays a crucial role in an individual's quality of life, interpersonal relationships, and self-concept, particularly among older adults residing in residential aged care facilities, including those with dementia. However, there is currently a limited person-centered approach to understanding the unique preferences of each older person regarding their intimate and sexual behaviors. To address this gap, the Intimacy and Sexuality Expression Preference (ISEP) tool was developed to facilitate meaningful discussions between healthcare professionals or workers and older individuals about their intimacy and sexuality needs and preferences. This paper explores the use of the ISEP tool with residents in long-term aged care, including those with dementia via a user-centric case study.MethodsISEP tool interviews were conducted with 14 residents in a single residential aged care facility in Queensland, Australia.ResultsThe study presented valuable insights and contextual information from using the ISEP tool, including an example of a resident's response, which provided recommendations for better supporting the resident. This involves engaging in supportive conversations to facilitate the exploration, implementation, and assessment of practical and actionable strategies to meet intimacy and sexuality needs and preferences.DiscussionThe ISEP tool shows promise in improving care practices and addressing the intimacy and sexuality needs of older individuals in aged care facilities. However, it is important to acknowledge that the study was conducted in a single aged care facility with a small group of residents, potentially limiting the generalisability of the findings. Further large-scale studies are necessary to establish the tool's broader applicability across different care settings.
South African adolescents' lived experiences of acquired hearing loss following multidrug-resistant tuberculosis treatment
Authors: Sparg Tarryn , Petersen Lucretia , Mayers Pat , Rogers Christine 
Published: February 2024

ObjectiveThe impact of acquiring hearing loss might be exacerbated during adolescence, as this normal transition from childhood to adulthood is characterised by identity construction and social intensity. This study aimed to describe the lived experiences of South African adolescents with acquired hearing loss following aminoglycoside treatment for multidrug resistant tuberculosis.DesignThe study adopted a descriptive phenomenological design and in-depth, semi-structured interviews were conducted in English, isiZulu and Afrikaans. The data was managed and analysed according to a modified version of Hycner's framework.Study sampleSix participants aged 16–24 years with bilateral, mild to profound hearing loss acquired from aminoglycoside treatment were recruited from two South African provinces.ResultsThree themes emerged which created a triple burden for participants. They endured socio-economic hardship encompassing limited economic and emotional support. Participants battled the consequences of life-threatening MDR-TB including illness, hospitalisation, stigma, and other challenges. Finally, participants were left with life-changing hearing loss.ConclusionThe findings indicate the necessity of holistic management of adolescents with aminoglycoside-related acquired hearing loss and serves as motivation to improve ototoxic monitoring practices and patient uptake of monitoring services and calls for the cessation, or at least cautious use, of aminoglycosides.
Genomic Insights into Staphylococcus aureus Isolates Exhibiting Diminished Daptomycin Susceptibility
Authors: Gómez-Casanova Natalia , Gutiérrez-Zufiaurre Mª Nieves , Blázquez de Castro Ana Mª , Muñoz-Bellido Juan Luis 
Published: February 2024

Daptomycin is one of the last therapeutic resources for multidrug-resistant gram-positive bacteria. Despite its structural similarities with glycopeptides, its mechanisms of action and resistance are different and in some respects are not completely understood. Mutations in several genes have been associated with daptomycin resistance, especially in mprF, walkR, rpoB and rpoC, but their role and importance remain to be elucidated. We have studied mutations in 11 genes, which have been previously associated with daptomycin non-susceptibility, in nine daptomycin-non-susceptible Staphylococcus aureus clinical isolates (daptomycin MIC: >1 mg/L). Susceptibility to daptomycin, vancomycin, linezolid, oxacillin, telavancin and dalbavancin was studied. walkR, agrA, cls1, cls2, fakA, pnpA, clpP, prs, rpoB, rpoC and mprF were amplified by PCR and sequenced. The sequences were compared with the S. aureus ATCC 25923 complete genome (GenBank gi: 685631213) by using BLAST® software. We did not find any changes in walkR, pnpA, prs and clpP. All isolates excepting isolate MSa5 showed a high number of significant mutations (between 13 and 25 amino acid changes) in mprF. Most isolates also showed mutations in the rpo genes, the cls genes and fakA. Daptomycin non-susceptibility in S. aureus clinical isolates seems to be reached through different mutation combinations when compared to S. aureus ATCC 25293. Especially mprF and cls1 showed very high polymorphism in most isolates. Meanwhile, one isolate, MSa5, showed only single mutation in mprF (P314T).
As estratégias de indeterminação do sujeito na construção de artigos de opinião no Ensino Fundamental: da norma gramatical à variação linguística
Authors: Da Silva de Souza Daniela 
Published: February 2024

O artigo apresenta uma pesquisa de cunho variacionista com o objetivo de verificar quais estratégias de indeterminação são utilizadas por estudantes concluintes do Ensino Fundamental na redação de artigos de opinião. A pesquisa fundamenta-se nos postulados teóricos de Duarte (2007), Bravin (2012) e Perini (2010) que consideram a existência de mais estratégias de indeterminação além das duas que a Gramática Tradicional define. Os resultados obtidos mostram que os estudantes fazem uso de um variado número de estratégias de indeterminação, além das referendadas pela tradição gramatical, que, por outro lado, foram pouco utilizadas. Ademais, também apontam para a necessidade de a escola repensar o modo como vem trabalhando o tema caso deseje realizar um trabalho pedagógico produtivo e reflexivo em consonância com os documentos oficiais que regulam o ensino de Língua Portuguesa.
Ritmo, poética y subjetividad. El anclaje enunciativo de la semiótica tensiva
Authors: Estay Stange Verónica , Moutat Audrey 
Published: February 2024

Este artículo propone una revisión de la teoría del ritmo esbozada por Claude Zilberberg en sus diferentes escritos, remitiéndola al tema de la subjetividad tal como se constituye en el discurso y gracias a él, a través del acto enunciativo. Se trata pues de establecer un diálogo entre la semiótica tensiva, la semiótica de las instancias enunciantes, y una fenomenología del lenguaje asociada a la problemática de la voz ―y, más profundamente, del soplo, cuyas propiedades semióticas fueron analizadas por Raúl Dorra―, con el objetivo de mostrar que, lejos de ser una abstracción objetivante, la hipótesis tensiva puede concebirse como un enfoque estrechamente vinculado al cuerpo, y gestado a flor de piel. Para ello, las consideraciones teóricas iniciales son confrontadas con el análisis de cuatro fragmentos de obras literarias ―un poema de Henri Michaux, una novela de Louis-Ferdinand Céline, un poema de Ghérasim Luca y una obra de teatro de Samuel Beckett― que ponen en evidencia el sustrato tensivo de la enunciación (y, más precisamente, del soplo enunciativo), así como la importancia del ritmo en el advenimiento del sujeto.
Visualization of slit defect by scanning nonlinear airborne ultrasound source technique using compressed sensing
Authors: Hamada Fumiya , Shimizu Kyosuke , Osumi Ayumu , Ito Youichi 
Published: February 2024

Abstract
A high-speed, non-contact non-destructive testing method using a scanning airborne ultrasound source and a nonlinear harmonic method has been developed for plate-like structures. The testing time depends on the scanning speed and the number of measurement points. To solve this problem, we propose using compressed sensing with this method. In this paper, we investigated visualizing Lamb wave propagation using the proposed compressed sensing method. In addition, we detected a slit defect by using the Lamb wave propagation image. Our results demonstrated that compressed sensing could be used to reduce the testing time.
Anisotropic properties of acoustically induced electric polarization in soft fibrous biological tissues
Authors: Kikuchi Junna , Sakakura Yuki , Ikushima Kenji 
Published: February 2024

Abstract
Acoustically induced electric polarization and its anisotropy in soft fibrous biological tissues were investigated under wet conditions. Assuming that fibrous tissues have polar uniaxial symmetry, stress-induced polarization should occur in the direction of fiber orientation in the non-shear terms of the piezoelectric tensor. Using the acoustically stimulated electromagnetic method, we measured the anisotropic properties of acoustically induced polarization in wet samples of Achilles tendon, skeletal muscle, and aortic wall. In all these tissues, the major non-shear term was confirmed to be

d

33

,

with polarization occurring along the fibrous direction. In Achilles tendon, which contains highly oriented collagen fibers, the uniaxially symmetric fiber structure explains the anisotropic polarization well. However, substantial polarization perpendicular to the fiber orientation (the

d

11

term) was observed in skeletal muscle and aortic wall, suggesting that the presence of fiber crimps and complex extracellular matrix produces polarization that does not occur in the uniaxially symmetric structures.
Evaluation of polar alignment structure and surface anchoring energy in ferroelectric nematic liquid crystals by renormalized transmission spectroscopic ellipsometry
Authors: Abe Sakunosuke , Nakagawa Amon , Shibata Yosei , Kimura Munehiro , Akahane Tadashi 
Published: February 2024

Abstract
It is essential to estimate the surface polar anchoring energy in order to discuss the interfacial orientation of ferroelectric nematic liquid crystals. In this study, we accurately estimated the twist angle of a

π

-twist cell with an antiparallel rubbing manner, by means of renormalized transmission spectroscopic ellipsometry, which has a great deal of experience in measuring the twist angle of ordinary nematic liquid crystals. We also succeeded in estimating the reduced polar anchoring energy from the essential equation derived from the simplified torque balance equation. It is assumed that the reduced surface polar anchoring energy is on the order of 102.
Fault Detection and Condition Monitoring in District Heating Using Smart Meter Data
Authors: Theusch Felix , Klein Patrick , Bergmann Ralph , Wilke Wolfgang , Bock Wolfgang , Weber Adrian 
Published: February 2024

Currently, large amounts of smart meter data are mainly used for billing purposes only, although they could also be valuable for decision support and business process optimization in customer service and maintenance. Therefore, this paper presents several relevant use cases for prognostics and health management based on a case study of a real meter data set of a medium-sized geothermal district heating network in southern Germany. First, we show the implementation of a machine learning algorithm for automatic fault detection. Our approach uses cluster analysis to categorize the different load cycles of a district heating substation and calculates a regression function between the demanded thermal energy and the outdoor temperature for each cluster. Thereby, the substation's control behaviour is learned and deviations due to a malfunction or failure can be detected in advance. In addition to the regression-based fault detection, we present two key performance indicators that can be computed relatively simple but resulting in very effective insights for condition monitoring and identifying substations with highly negative effects on the overall network. Our findings' correctness and usefulness were verified by the corresponding domain experts of the geothermal district heating company.
Finally, we provide an outlook on smart meter data's role for the further development of intelligent district heating networks and the realization of highly complex approaches such as smart grids. To foster future research, we provide exemplary our RapidMiner processes as well as some sample data.
Transformasi E-Government: Mengevaluasi Dampak Digitalisasi terhadap Pelayanan Publik
Authors: Taufiqurokhman Taufiqurokhman , Irwansyah Denny , Damanik Fritz Hotman Syahmahita , Nurhakim Arif , Judijanto Loso 
Published: February 2024

Transformasi E-Government menjadi topik utama dalam konteks pelayanan publik, seiring dengan meningkatnya penggunaan teknologi digital. Artikel ini bertujuan untuk mengevaluasi dampak digitalisasi terhadap pelayanan publik melalui transformasi E-Government. Evaluasi ini mencakup analisis perubahan signifikan dalam cara pemerintah menyediakan layanan kepada masyarakat melalui penerapan teknologi informasi dan komunikasi.
Dalam konteks ini, latar belakang penelitian mengidentifikasi kebutuhan untuk menyelaraskan pelayanan publik dengan perkembangan teknologi digital guna meningkatkan efisiensi, aksesibilitas, dan responsivitas. Research gap terletak pada pemahaman mendalam terkait dampak nyata dari transformasi E-Government terhadap kualitas pelayanan publik.
Urgensi penelitian ini terletak pada pentingnya memahami sejauh mana digitalisasi mampu mengubah cara pemerintah berinteraksi dengan masyarakat. Melalui tinjauan terhadap penelitian terdahulu, artikel ini mengeksplorasi berbagai model dan strategi implementasi E-Government serta mengidentifikasi keberhasilan dan kendala yang terkait.
Dalam menganalisis dampak transformasi E-Government, artikel ini menyoroti aspek-aspek seperti peningkatan efisiensi administratif, partisipasi masyarakat, dan inovasi layanan publik. Di samping itu, pembahasan novelti melibatkan pemahaman lebih lanjut mengenai cara teknologi digital dapat diintegrasikan secara holistik dalam konteks pelayanan publik.
Tujuan dan manfaat penelitian ini adalah memberikan pandangan yang komprehensif tentang transformasi E-Government dan kontribusinya terhadap peningkatan kualitas pelayanan publik. Dengan menggambarkan dampak positif dan tantangan yang mungkin dihadapi, artikel ini berupaya menyajikan gambaran yang holistik dan mendalam terkait peran teknologi dalam meningkatkan efektivitas pemerintah dalam melayani masyarakat.
ОСОБЛИВОСТІ КЛІНІКИ, ДІАГНОСТИКИ ОНІХОМІКОЗІВ СТОП ТА ПРИНЦИПИ КОМПЛЕКСНОЇ ТЕРАПІЇ
Authors: Aiziatulov Rushan 
Published: February 2024

Мета роботи. На підставі аналізу джерел літератури, власних спостережень вивчити клінічні особливості оніхомікозів стоп і розробити тактику комплексного лікування.
Матеріали і методи. Під спостереженням були хворі на оніхомікоз стоп. Проводилися лабораторні дослідження: загальний аналіз крові; аналіз сечі; дослідження функції печінки; мікроскопічне дослідження патологічного матеріалу на гриби зі зрізів уражених нігтів.
Результати і обговорення. Згідно нашим клінічним спостереженням сприятливі терапевтичні результати досягалися при використанні системних антимікотичних препаратів ітраконазол та тербінафін, а найбільш безпечним застосуванням була пульс-терапії. Ітраконазол призначався внутряшньо після їжі по 2 капсули по 100 мг 2 рази на день (400 мг на добу) протягом 7 днів, потім перерва 3 тижні і курс повторювався (всього 3-4 курси залежно від форми оніхомікозу, площі ураження). Тербінафін призначався внутрішньо в дозі 500 мг на добу (1 тиждень) з наступною 3-тижневою перервою (такий курс повторювали двічі). Клінічну та мікологічну ефективність препаратів ітраконазол та тербінафін оцінювали через 12 місяців, внаслідок чого було підтверджено терапевтичний ефект при хорошій переносимості.
Висновки. Лікування оніхомікозів стоп необхідно проводити в дерматовенерологічних закладах, де мають бути необхідні кадрові ресурси, здатні покращити якість життя пацієнтів, що є першочерговим завданням лікування будь-якого хронічного захворювання.
Pendidikan Tasawuf dalam Kitab Al-Hikam Karya Syekh Ibnu Atha’illah As-Sakandari
Authors: Qudsiyyah Fitroh , Hanipudin Sarno , Sajidin Sajidin 
Published: February 2024

Penelitian tentang pendidikan tasawuf ini mengambil referensi utama yaitu kitab Al-Hikam karya Syekh Ibnu Atho’illah As-Sakandari. Penelitian ini merupakan library research yaitu meneliti dokumen berupa buku, koran, artikel, atau jurnal-jurnal lainnya untuk mengetahui kandungan yang bisa didapat dalam kitab tersebut. Tujuan penelitian ini adalah untuk mengetahui bagaimana konsep pendidikan tasawuf dalam kitab Al-Hikam. Hasil penelitian menunjukan informasi bahwa pendidikan merupakan usaha membimbing dan membina serta bertanggung jawab untuk mengembangkan intelektual pribadi anak didik ke arah kedewasaan dan dapat menerapkannya dalam kehidupan sehari-hari. Sedangkan konsep pendidikan tasawuf dalam kitab Al-Hikam adalah usaha membersihkan diri dari sifat tercela dan menghiasinya dengan sifat terpuji, berjuang memerangi hawa nafsu sehingga jiwa tersebut bisa sampai kepada Allah SWT.
Kata kunci: Pendidikan Tasawuf, Kitab Al-Hikam, Ibnu ‘Athaillah
Transcatheter arterial chemoembolization combined with PD-1 inhibitors and Lenvatinib for hepatocellular carcinoma with portal vein tumor thrombus
Authors: Wu Hong-Xiao , Ding Xiao-Yan , Xu Ya-Wen , Yu Ming-Hua , Li Xiao-Mi , Deng Na , Chen Jing-Long 
Published: February 2024

BACKGROUND
Hepatocellular carcinoma (HCC) patients complicated with portal vein tumor thrombus (PVTT) exhibit poor prognoses and treatment responses.
AIM
To investigate efficacies and safety of the combination of PD-1 inhibitor, transcatheter arterial chemoembolization (TACE) and Lenvatinib in HCC subjects comorbid with PVTT.
METHODS
From January 2019 to December 2020, HCC patients with PVTT types I-IV were retrospectively enrolled at Beijing Ditan Hospital. They were distributed to either the PTL or TACE/Lenvatinib (TL) group. The median progression-free survival (mPFS) was set as the primary endpoint, while parameters like median overall survival, objective response rate, disease control rate (DCR), and toxicity level served as secondary endpoints.
RESULTS
Forty-one eligible patients were finally recruited for this study and divided into the PTL (n = 18) and TL (n = 23) groups. For a median follow-up of 21.8 months, the DCRs were 88.9% and 60.9% in the PTL and TL groups (P = 0.046), res-pectively. Moreover, mPFS indicated significant improvement (HR = 0.25; P < 0.001) in PTL-treated patients (5.4 months) compared to TL-treated (2.7 months) patients. There were no treatment-related deaths or differences in adverse events in either group.
CONCLUSION
A triplet regimen of PTL was safe and well-tolerated as well as exhibited favorable efficacy over the TL regimen for advanced-stage HCC patients with PVTT types I-IV.
Immunoglobulin G-mediated food intolerance and metabolic syndrome influence the occurrence of reflux esophagitis in Helicobacter pylori-infected patients
Authors: Wang Li-Hui , Su Bin-Bin , Wang Sheng-Shu , Sun Guan-Chao , Lv Kun-Ming , Li Yi , Shi Hui , Chen Qian-Qian 
Published: February 2024

BACKGROUND
Reflux esophagitis has an increasing prevalence and complex and diverse symptoms. Identifying its risk factors is crucial to understanding the etiology, prevention, and management of the disease. The occurrence of reflux esophagitis may be associated with food reactions, Helicobacter pylori (H. pylori ) infection, and metabolic syndromes.
AIM
To investigate the risk factors for reflux esophagitis and analyze the effects of immunoglobulin (Ig) G-mediated food intolerance, H. pylori infection, and metabolic syndrome on reflux esophagitis.
METHODS
Outpatients attending the Second Medical Center of the PLA General Hospital between 2017 and 2021 were retrospectively enrolled. The patients’ basic information, test results, gastroscopy results, H. pylori test results, and IgG-mediated food intolerance results were collected. Multivariate logistic regression analysis was used to analyze risk factors for reflux esophagitis. Statistical mediation analysis was used to evaluate the effects of IgG-mediated food intolerance and metabolic syndrome on H. pylori infection affecting reflux esophagitis.
RESULTS
A total of 7954 outpatients were included; the prevalence of reflux esophagitis, IgG-mediated food intolerance, H. pylori infection, and metabolic syndrome were 20.84%, 61.77%, 35.91%, and 60.15%, respectively. Multivariate analysis showed that the independent risk factors for reflux esophagitis included IgG-mediated food intolerance (OR = 1.688, 95%CI: 1.497-1.903, P < 0.00001) and metabolic syndrome (OR = 1.165, 95%CI: 1.030-1.317, P = 0.01484), and the independent protective factor for reflux esophagitis was H. pylori infection (OR = 0.400, 95%CI: 0.351-0.456, P < 0.00001). IgG-mediated food intolerance had a partially positive mediating effect on H. pylori infection as it was associated with reduced occurrence of reflux esophagitis (P = 0.0200). Metabolic syndrome had a partially negative mediating effect on H. pylori infection and reduced the occurrence of reflux esophagitis (P = 0.0220).
CONCLUSION
Patients with IgG-mediated food intolerance and metabolic syndrome were at higher risk of developing reflux esophagitis, while patients with H. pylori infection were at lower risk. IgG-mediated food intolerance reduced the risk of reflux esophagitis pathogenesis in patients with H. pylori infection; however, metabolic syndrome increased the risk of patients with H. pylori infection developing reflux esophagitis.