bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elderly people's attitudes and perceptions of aging and old age: the role of cognitive dissonance?
Authors: Ron Pnina 
Published: June 2007

AbstractObjectiveThe aim of the research was to examine if and, how the attitudes and perceptions were changing during the aging process. The research sample included three hundred and eighty‐eight elderly people between the ages of 65–92 who were sampled for the purpose of analyzing and comparing their attitudes and perceptions of old age and aging, in the present, to their attitudes and perceptions of these two concepts in the past.MethodThe research tool was composed of two parts: (A) a short demographic questionnaire which examined the following variables: gender, age, origin, family status and subjective health definition. (B) the second part was essentially qualitative in which subjects were asked via an ‘interviewer’ to reply to an identical question relating to two different periods in their lives: in their youth (when you were a young man/woman) and today. The data received from the questionnaires was processed in two main methods: quantitatively—statistically and qualitatively—content analysis.ResultsThe subjects' attitudes were categorized into six different typologies which were identified on a continuum: elderly people whose attitude towards old age and aging was negative both in the present and in the past were positioned at one end of the continuum. Subjects with a positive attitude towards old age, both in their youth and in the present were positioned at the opposite end of the continuum. Negative attitudes were more prominently described by powerful adjectives than positive attitudes were described by the subjects. For instance: ‘Fear’, ‘Disgust’. In the description of the positive attitude only one powerful adjective was used ‘Splendor and glory’.ConclusionsA significant correlation was found between subjects whose attitudes towards old age in the present were negative and those who subjectively defined their health as bad. Copyright © 2007 John Wiley & Sons, Ltd.
Immobilization of homing peptide on magnetite nanoparticles and its specificity in vitro
Authors: Gan Zhi‐Feng , Jiang Ji‐Sen , Yang Yong , Du Bing , Qian Min , Zhang Ping 
Published: June 2007

AbstractAs a homing peptide, A54 is the most effective peptide specific to the human hepatocellular carcinoma cell. Homing peptide labeled with green fluorescent protein (A54‐GFP) was successfully immobilized on the surfaces of magnetic nanoparticles and characterized by Fourier transform infrared spectroscopy as well as fluorescence microscopy. The binding efficiency was analyzed by performing adsorption equilibrium and SDS‐PAGE electrophoresis. Specific binding of the nanoparticles functionalized with A54‐GFP to human hepatocellular carcinoma cells in vitro was visualized using fluorescence microscopy. The results demonstrated the specificity of A54‐GFP‐coated magnetic nanoparticle to tumor cell, pointing to its great potential in magnetic cell separation and purification, magnetic resonance imaging (MRI), magnetic hyperthermia, and drug targeting. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
Nanometer‐scale surface modification of Ti6Al4V alloy for orthopedic applications
Authors: Xie Jianhui , Luan Ben Li 
Published: June 2007

AbstractThis communication presents a novel technology to enhance the biocompatibility of bioinert Ti6Al4V alloy as implant materials for orthopaedic application. The surface of Ti6Al4V alloy was electrochemically activated in NaOH solution to create a porous structure with nanometer topographic features and an alkaline environment, thus promoting the formation of bone‐like hydroxyapatite coating and enhancing the bonding strength of the coating. This innovative activation process was proved to be effective and essential. The activated surface was confirmed to be pure TiO2 and the formed coating was characterized of pure hydroxyapatite with a nanometer‐scaled grain size structure by means of XPS, FESEM/SEM/EDX, XRD, and TEM techniques. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
Connecting evolutionary morphology to genomics using ontologies: a case study from Cypriniformes including zebrafish
Authors: Mabee Paula M. , Arratia Gloria , Coburn Miles , Haendel Melissa , Hilton Eric J. , Lundberg John G. , Mayden Richard L. , Rios Nelson , Westerfield Monte 
Published: June 2007

AbstractOne focus of developmental biology is to understand how genes regulate development, and therefore examining the phenotypic effects of gene mutation is a major emphasis in studies of zebrafish and other model organisms. Genetic change underlies alterations in evolutionary characters, or phenotype, and morphological phylogenies inferred by comparison of these characters. We will utilize both existing and new ontologies to connect the evolutionary anatomy and image database that is being developed in the Cypriniformes Tree of Life project to the Zebrafish Information Network (HYPERLINK “file://localhost/Library/Local%20Settings/Temp/zfin.org” zfin.org) database. Ontologies are controlled vocabularies that formally represent hierarchical relationships among defined biological concepts. If used to recode the free‐form text descriptors of anatomical characters, evolutionary character data can become more easily computed, explored, and mined. A shared ontology for homologous modules of the phenotype must be referenced to connect the growing databases in each area in a way that evolutionary questions can be addressed. We present examples that demonstrate the broad utility of this approach.J. Exp. Zool. (Mol. Dev. Evol.) 308B:655–668, 2007. © 2007 Wiley‐Liss, Inc.
Astrocytic connexin distributions and rapid, extensive dye transfer via gap junctions in the inferior colliculus: Implications for [14C]glucose metabolite trafficking
Authors: Ball Kelly K. , Gandhi Gautam K. , Thrash Jarrod , Cruz Nancy F. , Dienel Gerald A. 
Published: June 2007

AbstractThe inferior colliculus has the highest rates of blood flow and metabolism in brain, and functional metabolic activity increases markedly in response to acoustic stimulation. However, brain imaging with [1‐ and 6‐14C]glucose greatly underestimates focal metabolic activation that is readily detected with [14C]deoxyglucose, suggesting that labeled glucose metabolites are quickly dispersed and released from highly activated zones of the inferior colliculus. To evaluate the role of coupling of astrocytes via gap junctions in dispersal of molecules within the inferior colliculus, the present study assessed the distribution of connexin (Cx) proteins in the inferior colliculus and spreading of Lucifer yellow from single microinjected astrocytes in slices of adult rat brain. Immunoreactive Cx43, Cx30, and Cx26 were heterogeneously distributed; the patterns for Cx43 and Cx 30 differed and were similar to those of immunoreactive GFAP and S100β, respectively. Most Cx43 was phosphorylated in resting and acoustically stimulated rats. Dye spreading revealed an extensive syncytial network that included thousands of cells and perivasculature endfeet; with 8% Lucifer yellow VS and a 5‐min diffusion duration, about 6,100 astrocytes (range 2,068–11,939) were labeled as far as 1–1.5 mm from the injected cell. The relative concentration of Lucifer yellow fell by 50% within 0.3–0.8 mm from the injected cell with a 5‐min diffusion interval. Perivascular dye labeling was readily detectable and often exceeded dye levels in nearby neuropil. Thus, astrocytes have the capability to distribute intracellular molecules quickly from activated regions throughout the large, heterogeneous syncytial volume of the inferior colliculus, and rapid trafficking of labeled metabolites would degrade resolution of focal metabolic activation. © 2007 Wiley‐Liss, Inc.
Hepatocyte growth factor‐induced enhancement of dendritic branching is blocked by inhibitors of N‐methyl‐D‐aspartate receptors and calcium/calmodulin‐dependent kinases
Authors: Tyndall Stephanie J. , Patel Sandip J. , Walikonis Randall S. 
Published: June 2007

AbstractHepatocyte growth factor (HGF) and its receptor, Met, are clustered at excitatory synapses and can enhance N‐methyl‐D‐aspartate (NMDA) receptor current and promote formation of neurites and dendrites. In this study, we examine the effects of HGF on dendritic arborization in mature cultures of dissociated hippocampal neurons. Exogenous HGF treatment caused a dose‐dependent increase in total dendritic branch tip number, total dendritic branch length, and dendritic complexity in these neurons. NMDA receptor activity has been linked to changes in dendritic structure, so we tested the effects of HGF on the dendritic arbor in the presence of DL‐2‐amino‐5‐phosphonopentanoic acid (APV), an NMDA receptor inhibitor. APV blocked the HGF‐induced enhancement of the dendritic arbor in a dose‐dependent manner. Similarly, pretreatment of neurons with KN62, an inhibitor of calcium‐dependent kinases, suppressed changes in dendritic branching induced by HGF. These results suggest that HGF initiates Ca2+‐dependent processes, so we examined the effect of HGF on intracellular calcium levels and autophosphorylation of the calcium/calmodulin‐dependent protein kinase II (CaMKII). HGF caused a persistent increase in fluorescence in clusters along dendrites of neurons preloaded with the Ca2+ indicator Fluo‐4. HGF treatment also enhanced autophosphorylation of CaMKII. The increases in Fluo‐4 fluorescence and autophosphorylation of CaMKII were blocked by pretreatment of neurons with APV. These results indicate that HGF stimulates Ca2+ influx into dendrites through the NMDA receptor and that this effect is necessary for the changes in dendritic morphology induced by HGF. © 2007 Wiley‐Liss, Inc.
Effects of EP1 receptor on cerebral blood flow in the middle cerebral artery occlusion model of stroke in mice
Authors: Saleem Sofiyan , Li Rung‐chi , Wei Guo , Doré Sylvain 
Published: June 2007

AbstractThe lipid mediator prostaglandin E2 (PGE2) exhibits diverse biologic activity in a variety of tissues. Four PGE2 receptor subtypes (EP1–4) are involved in various physiologic and pathophysiologic conditions, but differ in tissue distribution, ligand‐binding affinity, and coupling to intracellular signaling pathways. To characterize the role of the EP1 receptor, physiologic parameters (mean arterial blood pressure, pH, blood gases PaO2 and PaCO2, and body temperature), cerebral blood flow (CBF), and neuronal cell death were studied in a middle cerebral artery occlusion model of ischemic stroke in wild‐type (WT) and EP1 knockout (EP1−/−) mice. The right middle cerebral artery was occluded for 60 min, and absolute CBF was measured by [14C] iodoantipyrine autoradiography. The effect of EP1 receptor on oxidative stress in neuronal cultures was investigated. Although no differences were observed in the physiologic parameters, CBF was significantly (P < 0.01) higher in EP1−/− mice than in WT mice, suggesting a role for this receptor in physiologic and pathophysiologic control of vascular tone. Similarly, neuronal cultures derived from EP1−/− mice were more resistant (90.6 ± 5.8% viability) to tert‐butyl hydroperoxide‐induced oxidative stress than neurons from WT mice (39.6 ± 17.2% viability). The EP1 receptor antagonist SC‐51089 and calcium channel blocker verapamil each attenuated the neuronal cell death induced by PGE2. Thus, the prostanoid EP1 receptor plays a significant role in regulating CBF and neuronal cell death. These findings suggest that pharmacologic modulation of the EP1 receptor might be a means to improve CBF and neuronal survival during ischemic stroke. © 2007 Wiley‐Liss, Inc.
Enhancement of susceptibility of adult mouse brain to cytomegalovirus infection by infusion of epidermal growth factor
Authors: Han Gui‐Ping , Li Li , Kosugi Isao , Kawasaki Hideya , Tsuchida Takashi , Miura Kastsutoshi , Tsutsui Yoshihiro 
Published: June 2007

AbstractNeural precursor cells, including neural stem and progenitor cells, in the subventricular zone (SVZ) are the main targets for cytomegalovirus (CMV) infection in developing brains. The neural precursor cells in the SVZ of the adult brain have been reported to respond by proliferating after infusion with epidermal growth factor (EGF). Here we report the susceptibility of the precursor cells in the adult mouse brain to murine CMV (MCMV) infection. Adult mouse brains from 10‐, 25‐, and 70‐week‐old (W) mice were infused with either phosphate‐buffered saline or EGF into the brain for 3 days, and then intracerebrally infected with MCMV for 5 days. The susceptibility of the adult brains to MCMV was significantly increased by infusion of EGF in terms of viral titers and viral antigen‐positive cells. The susceptibility of the young adult brain from 10‐week‐old mice to MCMV was higher than that of the adult brains from 25‐week‐old or 70‐week‐old mice. Both the ependymal and the SVZ cells were susceptible to MCMV infection. The number of virus‐infected cells in the SVZ was significantly increased by infusion of EGF, whereas the number of infected ependymal cells was not significantly increased. Among the virus‐infected cells in the SVZ, 73% were positive for nestin, 87% were positive for Musashi, 86% were positive for GFAP, and 96% were positive for PCNA. These results indicate that the susceptibility of the adult brain to MCMV is correlated with the proliferative ability of the neural precursor cells in the SVZ of the adult brain. © 2007 Wiley‐Liss, Inc.
Variation in the secreted frizzled‐related protein‐3 gene and risk of Osteolysis and heterotopic ossification after total hip arthroplasty
Authors: Gordon Andrew , Southam Lorraine , Loughlin John , Wilson Anthony Gerard , Stockley Ian , Hamer Andrew J. , Eastell Richard , Wilkinson Jeremy Mark 
Published: June 2007

AbstractSecreted frizzled‐related protein‐3 (sFRP3) antagonizes ligands that promote new bone formation in adult tissues. We examined whether variation in the FRZB gene that encodes sFRP3 is associated with development of osteolysis or heterotopic ossification (HO) after total hip arthroplasty (THA). Genomic DNA was extracted from 609 subjects (osteolysis group n = 268) at a mean of 11 years following cemented THA for idiopathic osteoarthritis and genotyped for the FRZB Arg200Trp and Arg324Gly polymorphisms. The Brooker classification was used to assess HO following primary THA in 563 of the subjects. The carriage rate of the FRZB 200Trp allele was 14.2% in subjects with osteolysis versus 21.0% in controls (p = 0.041). The carriage rate of this allele was 21.7% in subjects with HO (n = 299) versus 12.0% in those without HO (p = 0.063). The odds ratio for osteolysis with carriage of FRZB 200Trp was 0.62 (95% CI 0.38 to 0.99; p = 0.049) and for HO was 1.64 (1.05 to 2.54; p = 0.028), after adjustment for the effects of other risk factors associated with the development of osteolysis or HO. Variants in the FRZB 324 locus alone were not associated with osteolysis or HO. However, the most frequent haplotype (FRZB 200Arg:324Arg) was associated with osteolysis (OR 1.50, 95% CI 1.09 to 2.07; p = 0.014). Our data suggest that the FRZB Arg200Trp locus may be a marker for pro‐osteoblastic activity after THA. Carriage of the FRZB 200Trp allele is associated with a “positive” bone balance phenotype (osteolysis −: HO+). © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:1665–1670, 2007
Thermo‐oxidative stability of ionic liquids as lubricating fluids
Authors: Minami Ichiro , Kamimura Hideto , Mori Shigeyuki 
Published: June 2007

AbstractThermo‐oxidative stability of ionic liquids was evaluated by three bulk‐scale tests. The changes in chemical and physical properties such as viscosity, deposit formation, weight loss and TAN were obtained. The results are discussed in terms of chemical structure of ionic liquids. TFSI derivatives exhibit good thermo‐oxidative stability in comparison with BF4 derivatives. As chain length of alkyl group in imidazolium‐cationic moiety increases, the thermo‐oxidative stability of the molecule decreases. Water contaminant promotes the thermo‐oxidative degradation of ionic liquids. Reaction mechanism via radical intermediates is proposed herein. Copyright © 2007 John Wiley & Sons, Ltd.
Nanoencapsulation of Stem Cells within Polyelectrolyte Multilayer Shells
Authors: Veerabadran Nalinkanth G. , Goli Poorna L. , Stewart‐Clark Skylar S. , Lvov Yuri M. , Mills David K. 
Published: June 2007

AbstractMouse mesenchymal stem cells have been individually encased by polyelectrolyte layers of poly (L‐lysine) and hyaluronic acid using the electrostatic layer‐by‐layer assembly technique, resulting in a shell consisting of nanolayers of thickness around 6–9 nm. Maintenance of cell morphology and viability were demonstrated for up to one week. Further adjustments to shell permeability and flexibility will facilitate the use of these encapsulated cells in tissue engineering and targeted‐delivery applications.magnified image
Polysiloxane Softener Coatings on Plasma‐Treated Wool: Study of the Surface Interactions
Authors: Canal Cristina , Molina Ricardo , Bertran Enric , Erra Pilar 
Published: June 2007

AbstractLow temperature plasma (LTP) improves the shrink‐resistance of wool fabrics but impairs their softness, so different polysiloxane coatings were applied. Modifications in surface hydrophilicity and topography of fabrics and fibres have been recorded through drop test, contact angle and SEM, respectively. LTP improves the deposition of the polysiloxanes which, depending on their functionalities alter the original hydrophilicity of the wool surface. Softness and shrink‐resist results of the fabrics point out to a possible relationship between hydrophilicity of the wool fibre surface and the shrinkage behaviour of the fabrics. A possible mechanism of interaction between the different polysiloxane groups and the surface of untreated (UT) and LTP‐treated wool is proposed.magnified image
Synthesis and Light‐Emitting Properties of New Polyimides Containing Ethynylene Units in the Main Chain
Authors: Chi Jun Ho , Park Se Hee , Lee Chang‐Lyoul , Kim Jang Joo , Jung Jin Chul 
Published: June 2007

AbstractTwo new polyimides (ODA‐PI and HDA‐PI) having 1,4‐phenylenediethynylene unit and octyloxy groups were synthesized. Judging from inherent viscosities of their precursor PAAs (1.42 and 1.62 dL · g−1), the two PIs were very high in molecular weight. Casting and thermal imidization of PAAs results polyimides with good‐quality films. They were stable up to 364 °C and showed no crystallites. UV‐vis and PL spectra in NMP solutions of both PIs showed maxima at 442 and 501 nm, respectively, while PL spectra in ≈10 µm thick films exhibited a maximum at 540 nm. CV indicates that two PIs were electrochemically active in redox region. The devices with construction of ITO/PEDOT/PIs/BAlq3/LiF/Al exhibited turn‐on voltages of 6.5 V in ODA‐PI and 7.5 V in HDA‐PI and emitted a bright bluish‐green light. ODA‐PI and HDA‐PI showed maximum luminescence of 256 and 316 cd · cm−2, respectively, at the same voltage of 12 V.magnified image
Physiogenomic association of statin‐related myalgia to serotonin receptors
Authors: Ruaño Gualberto , Thompson Paul D. , Windemuth Andreas , Seip Richard L. , Dande Amit , Sorokin Alexey , Kocherla Mohan , Smith Andrew , Holford Theodore R. , Wu Alan H. B. 
Published: June 2007

AbstractWe employed physiogenomic analyses to investigate the relationship between myalgia and selected polymorphisms in serotonergic genes, based on their involvement with pain perception and transduction of nociceptive stimuli. We screened 195 hypercholesterolemic, statin‐treated patients, all of whom received either atorvastatin, simvastatin, or pravastatin. Patients were classified as having no myalgia, probable myalgia, or definite myalgia, and assigned a myalgia score of 0, 0.5, or 1, respectively. Fourteen single nucleotide polymorphisms (SNPs) were selected from candidates within the 5‐HT receptor gene families [5a‐hydroxytryptamine receptor genes (HTR) 1D, 2A, 2C, 3A, 3B, 5A, 6, 7] and the serotonin transporter gene (SLC6A4). SNPs in the HTR3B and HTR7 genes, rs2276307 and rs1935349, respectively, were significantly associated with the myalgia score. Individual differences in pain perception and nociception related to specific serotonergic gene variants may affect the development of myalgia in statin‐treated patients. Muscle Nerve, 2007
Differences between bothersome and non‐bothersome night‐time frequency
Authors: Yoshimura Koji , Kamoto Toshiyuki , Oka Yasunori , Tsukamoto Taiji , Oshiro Kiyoshi , Suzukamo Yoshimi , Kinukawa Naoko , Ogawa Osamu 
Published: June 2007

AbstractAimsTo determine the distributions of bothersome and non‐bothersome nocturnal voiding and the differences between them using a community‐based study.Subjects and MethodsA total of 2,205 men and women aged 41–70 years from three Japanese towns responded to our postal questionnaire survey. The questionnaire included the International Prostate Symptom Score, Pittsburgh Sleep Quality Index (PSQI), Medical Outcome Study Short Form‐8, medical history of several diseases, and history of cigarette smoking and alcohol consumption. We chose subjects who had one or two episodes of nocturnal voiding per night and divided them into two subgroups based on the answer to a question on trouble sleeping due to nocturnal voiding in the PSQI. We compared data regarding lower urinary tract symptoms (LUTS), sleep, and general health‐related quality of life (GHQL) among these subgroups.ResultsOf the subjects: 314 (14.2%), 693 (31.4%), 149 (6.8%), and 168 (7.6%) had once‐bothersome, once‐non‐bothersome, twice‐bothersome, and twice‐non‐bothersome nocturnal voiding per night, respectively. Regarding LUTS, the twice‐bothersome nocturnal voiding group had the worst and the once‐non‐bothersome group had the best scores while the once‐bothersome and twice‐non‐bothersome nocturnal voiding groups had equivalent scores. Regarding sleep and GHQL, trouble sleeping but not the frequency of nocturnal voiding per se affected the scores. The twice‐non‐bothersome nocturnal voiding group generally had better scores than the once‐bothersome group, while the former had more frequent nocturnal voiding.ConclusionsSleep and GHQL of subjects with mild (once or twice) night‐time frequency are considerably impacted by sleeping troubles. Neurourol. Urodynam. 26:1014–1019, 2007. © 2007 Wiley‐Liss, Inc.
Municipal progress under manager government I. The story of Pasadena
Authors: Hall Halan W. 
Published: June 2007

AbstractThe test of city government is the comfort and well‐being which it affodsits citizens. Is the park system adeqquate; are the streets ample, clean and well paved; is the water supply good; is the city growing to a plan? This is the first of a series of articless which will describe how the cityi manager form is measuring up under these tests. Does more efficient government pay dividends? This and articles to follow will seek to answer the question.
Sunnyside gardens. A successful experiment in good housing at moderate prices
Authors: Bing Alexander M. 
Published: June 2007

AbstractSunnyside homes, built by the City Housing Corporation, a limited dividend company, are the result of the social vision and business ability of Mr. Bing. Solid brick, single‐family houses of six rooms can be bought for $8830 (ten per cent down and $66.78 per month). They are accessible to subway, elevated and bus lines. Private gardens, and community playgrounds and parks are provided. The corporation, which is in excellent financial condition, has brought good homes within range of New York City wage earnem.
Congestion de luxe—Do we want it?
Authors: Dykstra C. A. 
Published: June 2007

AbstractLast month Daniel Turner wrote on the vicious circle of rapid transit and congestion math special reference to New York City. This month Mr. Dykstra discusses the same problem from the standpoint of Los Angeles' experience. And the east and the west have met, for without any collusion or conspiracy the two authors have arrived at wirtually the same conclusions.