bluuebunny/crossref_metadata_2025_split huggingface dataset:
Memória e sentimento nas notas de falecimento da Revista Adventista no contexto da pandemia de Covid-19
Authors: Tonete Marcelino Marcio Adriano , Macedo de Novaes Allan 
Published: February 2024

Propósito: Este trabalho busca descrever como a pandemia de Covid-19 esteve presente nas narrativas fúnebres publicadas pela Revista Adventista (periódico centenário de circulação nacional) durante a crise sanitária, influenciando na constituição dessas memórias. Método: O estudo se desenvolveu a partir da análise documental das notas de falecimento publicadas na seção Memória, espaço tradicionalmente dedicado aos obituários. Foram selecionadas apenas as notas de falecimento que mencionavam a Covid-19 como causa mortis. Sendo assim, das 376 divulgadas no período de junho de 2020 a setembro de 2021, 124 se enquadraram nesse critério. Resultados: Foi possível perceber que a crise sanitária contribuiu para a ampliação da tradição de publicar obituários. Além de aumentar o número de páginas reservado às notas de falecimento, a revista criou um memorial on-line dedicado exclusivamente à memória das vítimas da pandemia. Isso permitiu que as famílias enlutadas pudessem prestar sua homenagem e gravar as memórias de seus entes queridos num contexto de negação do direito ao luto, restrições aos rituais fúnebres e sepultamentos rápidos. Conclusão: O cenário pandêmico parece ter influenciado na constituição das memórias em si, considerando o fato de algumas dessas narrativas obituárias terem destacado atitudes positivas dessas pessoas apesar do cenário caótico. Além disso, a publicação das notas de falecimento das vítimas da pandemia parece ter assumido também o sentido de registro do que foi a própria crise sanitária e seu impacto no adventismo.
ImmuneScore as a novel RNA-based prognostic signature superior to PD-L1 in advanced non-squamous NSCLC patients receiving chemotherapy combined with immune checkpoint inhibitor therapy
Authors: Lin Zhihuan , Zhan Jianhua , Zhang Li 
Published: February 2024

Aim: Our study aimed to explore the prognostic predictive potential of a novel RNA-based signature called ImmuneScore in advanced non-squamous NSCLC patients receiving combined immune checkpoint inhibitor (ICI) treatment and chemotherapy.
Methods: RNA-sequencing data of 113 patients screened out from ORIENT-11 trial were retrospectively analyzed. ImmuneScore was calculated by the ESTIMATE algorithm. The association of ImmuneScore with early tumor progression, progression-free survival (PFS), and overall survival (OS) was analyzed using chi-square test, Cox regression test, and log-rank test. Receiver operating characteristic (ROC) curves were generated, with higher values of area under the ROC curves (AUCs) indicating better prediction ability.
Results: ImmuneScore was negatively correlated with early tumor progression rate (4.3% vs. 18.6%, P = 0.013) while positively correlated with PFS (HR = 0.29, 95%CI: 0.16-0.53, P < 0.001) and OS (HR = 0.32,95%CI: 0.18-0.58, P < 0.001), demonstrating higher AUCs than that of Programmed death-ligand 1 (PD-L1) tumor proportion score (TPS) (early tumor progression: 0.64 vs. 0.68; PFS: 0.67 vs. 0.58; OS: 0.73 vs. 0.63). Nomograms integrating ImmuneScore and other significant variables (age and T-stage for PFS, gender and T-stage for OS) yielded good performance in PFS and OS prediction.
Conclusion: ImmuneScore serves as a novel RNA-based prognostic signature superior to PD-L1 in advanced non-squamous NSCLC patients receiving chemotherapy combined with ICI therapy. Higher ImmuneScore indicates lower early tumor progression rate, longer PFS, and longer OS.
REVISITING THE DYNAMIC CONNECTEDNESS, SPILLOVER AND HEDGING OPPORTUNITIES AMONG CRYPTOCURRENCY, COMMODITIES, AND ISLAMIC STOCK MARKETS
Authors: Mezghani Taicir , Rabbani Mustafa Raza , Trichilli Yousra , Abbes Boujelbène 
Published: February 2024

The study investigates the dynamic interconnections and opportunities for hedging among cryptocurrency, commodity, and Islamic stock markets using DCC-GARCH and Spillover connectedness models. Using daily data covering the Russia-Ukraine war and COVID-19 outbreak from December 1, 2019 to April 15, 2022, we document weak and frequently negative correlation between Bitcoin and Islamic stock markets. Thus, Bitcoin could be viewed as a haven from Islamic stock market losses. The results also indicate that Bitcoin's diversification benefits are normally steady and increase considerably during turbulence. Furthermore, the net return spillovers from the Bitcoin market remain above zero during most of the study period. We also find that utilizing Bitcoin as a hedge during the COVID-19 pandemic phase leads to higher expenses. The outcomes of this investigation are expected to carry substantial ramifications for Indonesian investors and portfolio managers who adhere to Shariah law since they will enable them to comprehend the advantages of diversifying portfolios across various periods of stock holding or investment horizons.
The THE ROLE OF ISLAMIC FINANCIAL INCLUSION ON POVERTY, INCOME INEQUALITY, AND HUMAN DEVELOPMENT IN INDONESIA
Authors: Novreska Sasiaprita , Arundina Tika 
Published: February 2024

This study empirically analyses the role of Islamic financial inclusion in overcoming poverty, income inequality, and human development problems by employing yearly panel data of 33 provinces in Indonesia from 2014 to 2022. The results show that, except Aceh and DKI Jakarta, all provinces in Indonesia have low Islamic Financial Inclusion Index (IFII). Our analysis reveals that Islamic financial inclusion exerts significant roles in poverty reduction and human development improvement, while it is insignificantly related to income inequality. During the Covid-19 pandemic, the effect on human development of financial inclusion is further strengthened. We further note that the effects of Islamic financial inclusion depends on the levels of Human Development Index (HDI), where poverty reduction and human development improvement are apparent only in provinces with high and very high HDI.
Modern Lines in Geochemistry: Anniversary Conference
Authors: Vorontsov A.A. , Kuzmin M.I. , Perepelov A.B. , Shatsky V.S. 
Published: February 2024

Abstract—On 21–25 November, 2022, Vinogradov Institute of Geochemistry, Siberian Branch of the Russian Academy of Sciences (Irkutsk), organized and held an All-Russian conference celebrating the 65th anniversary since the foundation of the Institute and the 105th anniversary since the birth of its first director, Academician Lev Vladimirovich Tauson, who headed the Institute from 1961 to 1989. The results reported at the conference encompass a wide range of research fields in modern geochemistry, including isotope geochemistry of igneous, metamorphic, and sedimentary rocks in various geodynamic settings; chemistry of ore-magmatic systems and modern methods of mineral exploration; environmental geochemistry, geoecology, and paleoclimate; laboratory modeling and thermodynamic calculations of natural and production-related processes and materials; advanced analytical methods and information technologies for geosciences. The conference presentations pay tribute to Lev Tauson whose academic carrier, as well as all creative activity, had been closely related with the development of the Institute of Geochemistry. The preface paper provides a review of topics discussed at the conference concerning various geodynamic and geochemical problems, including sources of material, petrogenesis, and metallogeny.
Real-Time Casing Point Selection Optimization for MPD Wells Through Improved Kick Tolerance Analysis
Authors: Callerio Santiago , Ashok Pradeepkumar , Oort Eric van 
Published: February 2024

Abstract
Traditional casing point selection fails to reflect influx dynamics and leverage managed pressure drilling (MPD) advancements in the well design process, which often leads to over-engineering and increased expenditure. This study proposes a new approach that integrates MPD into the casing design process, employing a reduced drift-flux model (RDFM) to account for complexity. The methodology aims to optimize casing design and enable real-time assessment of kick tolerance (KT) while drilling, exploiting opportunities for optimization.
In this study, we present a comprehensive approach for determining kick tolerance thresholds, considering current operating conditions and equipment limitations. Improving on industry-accepted rules of thumb for kick volume (25 bbl) and kick intensity (0.5 ppg), this work delivers a fit-for-purpose kick tolerance criterion. The research indicates that casing point selection can be significantly influenced by previously overlooked factors, such as the impact of temperature on formation stress, kick dilution in drilling fluid and annular distribution, as well as pressure and temperature effects and rig kick detection capabilities. Including these in the design criteria yields more accurate and efficient well construction planning and reduced well control risks. Practical case history results demonstrate the potential to extend critical sections by up to 60% while increasing the manageable kick volume, consequently eliminating at least 2 casing strings out of a 7 string well design.
The proposed methodology is shown to be suitable for real-time implementation, allowing drillers to make more informed decisions about casing point selection and section length extension while still ensuring safe well operations. This enhances the flexibility of the drilling process and leads to the reduction and simplification of over-engineered well schematics and excess number of casing strings, resulting in significant well construction cost savings.
This work presents a novel approach for MPD well design and casing point selection, considering overlooked factors such as case-specific defined thresholds for kick volume and intensity, complex gas behavior, and temperature-dependent formation stresses for pressure evaluation. Furthermore, it extends the scope to the drilling process by introducing the real-time assessment of KT, generating additional opportunities for optimization, and improving well control safety. In addition, it proves the suitability of an RDFM model for KT assessment.
Study on the Shearing Force of Ram and Fracture Characteristics of Drillpipe Under Precutting
Authors: Xiao Shihong , Xiang Maolin , Guo Jun , Cui Jiakai , Tang Qiulin , Jiang Junjie 
Published: February 2024

Summary
The working pressure of the hydraulic system, as well as the volume and weight of the ram blowout preventer (BOP), cannot be increased excessively. This limitation affects the shearing force provided by the hydraulic cylinder of the BOP. When shearing high-strength, large-thickness, and large-diameter drillpipes, it is easy to cause shear failure, making blowout control challenging. Therefore, we proposed a high-pressure water-jet-assisted precutting method to reduce the force required to shear the drillpipe. Based on the numerical model verified by experiments, we compared and analyzed the shearing force variations and drillpipe fracture characteristics under different precutting methods. We also provided recommendations for selecting precutting methods. Furthermore, we identified the weights and grades of drillpipes that affect the shearing force under precutting. The results demonstrate that precutting the drillpipe can reduce shear forces, shorten fracture time, and improve fracture quality. The use of water-jet precutting technology enhances the efficiency of emergency well shut-in operations and subsequent pipe fishing. The presented technology is currently at a prefeasibility stage, and further efforts are needed to implement these ideas in practice.
A compendium of ruminant gastrointestinal phage genomes revealed a higher proportion of lytic phages than in any other environments
Authors: Wu Yingjian , Gao Na , Sun Chuqing , Feng Tong , Liu Qingyou , Chen Wei-Hua 
Published: February 2024

Abstract
Background: Ruminants are important livestock animals that have a unique digestive system comprising multiple stomach compartments. Despite significant progress in the study of microbiome in the gastrointestinal tract (GIT) sites of ruminants, we still lack an understanding of the viral community of ruminants. Here, we surveyed its viral ecology using 2333 samples from ten sites along the GIT of eight ruminant species.
Results: We present the Unified Ruminant Phage Catalogue (URPC), a comprehensive survey of phages in the GITs of ruminants including 64,922 non-redundant phage genomes. We characterized the distributions of the phage genomes in different ruminants and GIT sites and found that most phages were organism-specific. We revealed that ~60% of the ruminant phages were lytic, which was the highest as compared with those in all other environments and certainly will facilitate their applications in microbial interventions. To further facilitate the future applications of the phages, we also constructed a comprehensive virus-bacteria/archaea interaction network and identified dozens of phages that may have lytic effects on methanogenic archaea.
Conclusions: The URPC dataset represents a useful resource for future microbial interventions to improve ruminant production and ecological environmental qualities. Phages have great potential for controlling pathogenic bacterial/archaeal species and reducing methane emissions. Our findings provide insights into the virome ecology research of the ruminant GIT and offer a starting point for future research on phage therapy in ruminants.
Emergence of heteroresistance to multiple antibiotics in Gram-negative clinical isolates from two Egyptian hospitals
Authors: Al-Shebiny Alaa G. , Shawky Riham M. , Emara Mohamed 
Published: February 2024

Abstract

Background
Antimicrobial resistance is a major global threat; the presence of resistance mechanisms in bacteria can provide a correlation between bacterial-genotype and -phenotype. However, exceptions exist where identical bacterial cells in a population can exhibit heterogeneity in terms of antibiotic susceptibility. This response leads to difficulties in unambiguously classifying bacteria as susceptible or resistant. Heteroresistance is an example of this phenomenon that describes a phenotype in which an isolate contains subpopulations with reduced susceptibility compared to its main-population. Heteroresistance emergence led to a diagnostic and therapeutic dilemma. This study aimed to genotypically characterize the difference between the sensitive and the stable heteroresistant isolates (SHI).
Methods
A total of 151 Enterobacteriaceae isolates from various sources were included. Heteroresistant isolates and their stability were detected by disc-diffusion technique while genotypic analysis was carried out by PCR and efflux activity was assessed by ethidium bromide (EtBr)-agar Cartwheel method.
Results
A total of 51 heteroresistant subpopulations were detected, producing 16 SHI upon stability-detection. Amplified resistance genes and EtBr-agar Cartwheel method showed a significant difference between resistant subpopulations and their corresponding-sensitive main-populations.
Conclusion
Genotypic analysis confirmed that genetic mutation can lead to resistance development although the main-populations were sensitive, thereby leading to treatment failure.
Enhancing Early Diagnosis of Bipolar Disorder in Adolescents
through Multimodal Neuroimaging
Authors: Wang Jie , Wu Jinfeng , Lin Kangguang , Lu Weicong , Zou Wenjin , Li Xiaoyue , Tan Yarong , Yang Jingyu , Zheng Danhao , Liu Xiaodong , Lam Bess , Xu Guiyun , Wang Kun , McIntyre Roger , Wang Fei , So Kwok-Fai 
Published: February 2024

Abstract
Background
Bipolar Disorder (BD), a severe neuropsychiatric condition, often manifests during adolescence. Traditional diagnostic methods, relying predominantly on clinical interviews and symptom assessments, may fall short in accuracy, especially when based solely on single-modal MRI techniques.
Objective
This study aims to bridge the diagnostic gap in adolescent BD by integrating behavioral assessments with a multimodal MRI approach. We hypothesize that this combination will enhance the accuracy of BD diagnosis in adolescents at risk.
Methods
A retrospective cohort of 309 subjects, including BD patients, offspring of BD patients (with and without subthreshold symptoms), non-BD offspring with subthreshold symptoms, and healthy controls, was analysed. Behavioral attributes encompassing psychiatric familial history and assessments were integrated with MRI morphological and network features derived from T1, fMRI, and DTI. Three diagnostic models were developed using GLMNET multinomial regression: a clinical diagnosis model based on behavioral attributes, an MRI-based model, and a comprehensive model integrating both datasets.
Results
The comprehensive model outperformed the clinical and MRI-based models in diagnostic accuracy, achieving a prediction accuracy of 0.83 (CI: [0.72, 0.92]), significantly higher than the clinical diagnosis approach (accuracy of 0.75) and the MRI-based approach (accuracy of 0.65). These findings were further validated with an external cohort, demonstrating a high accuracy of 0.89 (AUC = 0.95). Notably, structural equation modelling revealed that factors like Clinical Diagnosis, Parental BD History, and Global Function significantly impacted Brain Health, with Psychiatric Symptoms having a marginal influence.
Conclusion
This study underscores the substantial value of integrating multimodal MRI with behavioral assessments for early BD diagnosis in at-risk adolescents. The fusion of phenomenology with neuroimaging promises more accurate patient subgroup distinctions, enabling timely interventions and potentially improving overall health outcomes. Our findings suggest a paradigm shift in the diagnostic approach for BD, highlighting the necessity of incorporating advanced imaging techniques in routine clinical evaluations.
Cortical microstructural alterations along the Alzheimer’s disease continuum and association with amyloid and tau pathology
Authors: Zhang Jun , Hu qili , Li Fang , Wu Gujie 
Published: February 2024

Abstract
Multi-shell diffusion MRI offers considerable potential for the noninvasive mapping of Alzheimer’s disease (AD) pathology. Longitudinal studies examining the ability of Neurite Orientation Dispersion and Density Imaging (NODDI) technology to detect early neurodegenerative changes during AD’s preclinical stage are limited. Moreover, the correlation between cortical microstructural alterations and in vivo AD pathology, specifically amyloid and tau protein accumulation, requires further investigation. In this research, we assessed cortical microstructural changes across the AD spectrum, including 61 APOE-ɛ4 negative cognitively normal subjects, 28 APOE-ɛ4 positive cognitively normal subjects, 58 individuals with mild cognitive impairment, and 24 with AD dementia, as part of the Alzheimer’s Disease Neuroimaging Initiative. Assessments were made both cross-sectionally and longitudinally. We also examined the regional relationships between amyloid deposits, tau protein accumulation, and changes in cortical NODDI microstructure associated with AD. Our findings identified reductions in the Intracellular Volume Fraction, an increased isotropic volume fraction (ISOVF), and modifications to the Orientation Dispersion Index in AD-impacted regions. Notably, these modifications were observable across the AD continuum, including during preclinical stages. ISOVF, in particular, showed a positive correlation with the presence of tau and Aβ pathology in critical brain regions, potentially indicative of underlying neuroinflammation. Changes in NODDI metrics correlated with cognitive performance, especially in memory, and were found to partially mediate the link between tau pathology and cognitive function. These comprehensive results suggest NODDI’s potential as an early biomarker for AD detection, disease progression tracking, and therapeutic intervention, contributing fresh perspectives on the disease’s pathophysiology.
Factors Associated with Neonatal Sepsis among Neonates Admitted in Kibungo Referral Hospital, Ngoma District-Rwanda: A Retrospective Cross-Sectional Study
Authors: Niyoyita Jean Claude , Ndayisenga Jerome , Omolo Jared , Niyompano Hosee , Bimenyimana Pierre Celestin , Dzinamarira Tafadzwa , Nsekuye Olivier , Chavez Isabella , Hakizayezu François 
Published: February 2024

Abstract

About four million deaths occur every year worldwide due to neonatal sepsis, of which 99% take place in low-income countries. Nearly 71% of neonatal deaths are preventable and among these, 10% are due to neonatal sepsis. Nevertheless, limited information exists on neonatal sepsis and its associated factors in Rwanda. The objectives of the study were to find prevalence and factors associated with neonatal sepsis among neonates admitted in Kibungo Referral Hospital, Ngoma District, Rwanda. A retrospective cross-sectional study design was used to recruit all neonates admitted at Kibungo Hospital in 2017. Neonates related records were reviewed to collect data. Logistic regression and Odds ratios were calculated to identify the factors associated with neonatal sepsis at 95% CI, p < 0.05. A total of 422 neonates were enrolled in the study, 12.8% (n = 54) had neonatal sepsis, and 62% of blood culture revealedKlebsiella pneumoniae. Among neonates with neonatal sepsis, 38 (70%) recovered while 16 (30%) died. Strong association with neonatal sepsis was found with neonatal age less or equal to three days (AOR: 2.769, 95%; CI, 1.312–5.843;P = 0.008); and gestational weeks less than 37 weeks (aOR: 4.149; CI: 1.1878–9.167; p = < 0.001). Mothers and hospital environments should be monitored to prevent infection through the regular blood culturing and ward decontamination.