bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the elusive deep‐sea sharpnose sevengill shark (Heptranchias perlo) in the Adriatic Sea: Novel records, health assessments and conservation implications
Authors: Gajić Andrej A. 
Published: March 2024

Abstract

The sharpnose sevengill shark (Heptranchias perlo) is a rare and poorly understood deep‐sea species, with only a few records in the Adriatic Sea over the last two centuries and a significant gap in sightings.
Throughout 2023, three new records are documented in the southernmost Adriatic Sea, found at depths ranging from 391 to 452 m off Vlorë.
This study marks the first comprehensive health examination of a deep‐sea shark, investigating potential trauma and injuries resulting from trawling. It encompasses pathological and histopathological examinations, supplemented by magnetic resonance imaging (MRI).
The research highlights alarming post‐capture mortality rates in this data deficient species, discusses further conservation implications, and proposes protective measures for the species.
Beyond addressing critical knowledge gaps, this study advocates for collaborative efforts with local fishermen to establish long‐term monitoring and obtain data on the frequency and abundance of elusive species.
New discoveries from the early Māori village at Shag River Mouth, New Zealand, reveal intestinal parasites
Authors: Horrocks Mark , Presswell Bronwen , Smith Ian W.G. 
Published: March 2024

AbstractPresented here are the results of archaeoparasitological analysis of habitation layers at Shag River Mouth, Otago coast. Two types of helminth eggs were identified: The first type is Toxocara canis, associated with the introduced kurī dog (Canis familiaris), which could have adversely affected local people and their dogs. The other type very closely resembles that of Stringopotaenia psittacea, associated with the critically endangered endemic kākāpō (Strigops habroptilus) parrot. The results represent the first South Island archaeo parasitological identifications. There was no starch or associated material in the samples, such as introduced Polynesian crops and indigenous starchy Māori food plants. This lack is consistent with the interpretation of the site as that of a transient village focused on big game hunting.
How mitochondrial cristae illuminate the important role of oxygen during eukaryogenesis
Authors: Speijer Dave 
Published: March 2024

AbstractInner membranes of mitochondria are extensively folded, forming cristae. The observed overall correlation between efficient eukaryotic ATP generation and the area of internal mitochondrial inner membranes both in unicellular organisms and metazoan tissues seems to explain why they evolved. However, the crucial use of molecular oxygen (O2) as final acceptor of the electron transport chain is still not sufficiently appreciated. O2 was an essential prerequisite for cristae development during early eukaryogenesis and could be the factor allowing cristae retention upon loss of mitochondrial ATP generation. Here I analyze illuminating bacterial and unicellular eukaryotic examples. I also discuss formative influences of intracellular O2 consumption on the evolution of the last eukaryotic common ancestor (LECA). These considerations bring about an explanation for the many genes coming from other organisms than the archaeon and bacterium merging at the start of eukaryogenesis.
Pre‐saccadic shifts of attention in individuals diagnosed with schizophrenia
Authors: Lehet Matthew , Rolfs Martin , Bao Jacqueline , Fattal Jessica , Thakkar Katharine N. 
Published: March 2024

AbstractIntroductionPathophysiological theories of schizophrenia (SZ) symptoms posit an abnormality in using predictions to guide behavior. One such prediction is based on imminent movements, via corollary discharge signals (CD) that relay information about planned movement kinematics to sensory brain regions. Empirical evidence suggests a reduced influence of sensorimotor predictions in individuals with SZ within multiple sensory systems, including in the visual system. One function of CD in the visual system is to selectively enhance visual sensitivity at the location of planned eye movements (pre‐saccadic attention), thus enabling a prediction of the to‐be‐foveated stimulus. We expected pre‐saccadic attention shifts to be less pronounced in individuals with SZ than in healthy controls (HC), resulting in unexpected sensory consequences of eye movements, which may relate to symptoms than can be explained in the context of altered allocation of attention.MethodsWe examined this question by testing 30 SZ and 30 HC on a pre‐saccadic attention task. On each trial participants made a saccade to a cued location in an array of four stimuli. A discrimination target that was either congruent or incongruent with the cued location was briefly presented after the cue, during saccade preparation. Pre‐saccadic attention was quantified by comparing accuracy on congruent trials to incongruent trials within the interval preceding the saccade.ResultsAlthough SZs were less accurate overall, the magnitude of the pre‐saccadic attention effect generally did not differ across groups nor show a convincing relationship with symptom severity. We did, however, observe that SZ had reduced pre‐saccadic attention effects when the discrimination target (probe) was presented at early stages of saccade planning, when pre‐saccadic attention effects first emerged in HC.ConclusionThese findings suggest generally intact pre‐saccadic shifts of attention in SZ, albeit slightly delayed. Results contribute to our understanding of altered sensory predictions in people with schizophrenia.
Promoting green supply chain under carbon tax, carbon cap and carbon trading policies
Authors: Eslamipoor Reza , Sepehriyar Abbas 
Published: March 2024

AbstractThis article examines a supply chain network that considers both economic and environmental factors. The network faces challenges related to multi‐item products and non‐homogenous vehicle types with different costs. Additionally, the production process involves multiple energy sources that emit different levels of air pollution. The main objective is to maximise profits while adhering to different carbon policies. To achieve this goal, the paper presents several supply chain models that are compared under different schemes: no carbon policy (basic one), carbon tax policy, carbon emission policy and carbon trading policy. These models were coded and solved to demonstrate their effectiveness for different conditions and scenarios. The results provide valuable insights for supply chain managers, enabling them to make well‐established decisions for executive planning.
Responsible entrepreneurship, social innovation, and entrepreneurial performance: Does commitment to SDGs matter?
Authors: Adomako Samuel , Nguyen Nguyen Phong 
Published: March 2024

AbstractIn this study, we investigate the effect of responsible entrepreneurship on entrepreneurial performance through the mediating mechanism of social innovation. Further, we explore the moderating role of a firm's degree of sustainable development goals (SDGs) commitment on the relationship between social innovation and entrepreneurial performance. Data were collected from 220 firms in Ghana using a time‐lagged design. Our results show that responsible entrepreneurship has an indirect effect on entrepreneurial performance through social innovation. Moreover, the effect of social innovation on entrepreneurial performance is amplified when a firm's degree of SDGs commitment is higher. These findings contribute to the responsible entrepreneurship and social innovation literature.
Forensic assessment of somatoform and functional neurological disorders
Authors: Datta Vivek , Blum Austin W. 
Published: March 2024

AbstractFunctional neurological disorders (FND) and somatization are common in clinical practice and medicolegal settings. These conditions are frequently disabling and, if arising following an accident, may lead to claims for legal compensation or occupational disability (such as social security disability insurance). However, distinguishing FND and somatization from symptoms that are intentionally produced (i.e., malingered or factitious) may pose a major forensic psychiatric challenge. In this article, we describe how somatoform disorders and FND lie along a spectrum of abnormal illness‐related behaviors, including factitious disorder, compensation neurosis, and malingering. We provide a systematic approach to the forensic assessment of FND and conclude by describing common litigation scenarios in which FND may be at issue. Forensic testimony may play an important role in the resolution of such cases.
Framework for adaptive serious games
Authors: Pistono Alvaro Marcos Antonio de Araujo , dos Santos Arnaldo Manuel Pinto , Baptista Ricardo José Vieira , Mamede Henrique São 
Published: March 2024

AbstractProfessional training presents a significant challenge for organizations, particularly in captivating and engaging employees in these learning initiatives. With the ever‐evolving landscape of workplace education, various learning modes have emerged within organizations, and e‐learning stands out as a prominent choice. This increasingly cost‐effective and adaptable solution has revolutionized training by facilitating numerous learning activities, including the seamless integration of educational games driven by cutting‐edge technologies. However, incorporating serious games into educational and professional settings introduces its own set of challenges, particularly in quantifying their tangible impact on learning and assessing their adaptability across diverse contexts. Organizations require a consistent framework to guide best practices in implementing e‐learning combined with serious games in professional training. The primary objective of this research is to bridge this gap. Rooted in the methodology of Design Science Research, it aims to provide a comprehensive framework for creating and assessing adaptive serious games that achieve desired learning and engagement outcomes. The overarching goal is to enhance the teaching–learning process in professional training, ultimately elevating student engagement and boosting learning outcomes to new heights. The proposal is grounded in a review of literature, expert insights, and user experiences with Serious Games in professional training, considering learning outcomes and forms of adaptation as essential characteristics for developing or evaluating Serious Games. The result is a framework designed to guide learners toward improved learning outcomes and increased engagement. The proposal underwent evaluation through triangulation, involving focus groups and expert interviews. Additionally, it was utilized in the development and assessment of a Serious Game, offering new insights and application suggestions. This experiment provided an evaluation of the framework based on real courses. In summary, this investigation contributes to the development of evidence‐based approaches for the effective use of Serious Games in professional training.
Migrated subcutaneous sharp foreign body in the anterior chest wall: An unusual presentation
Authors: Devkota Shritik , Pokharel Prajjwal , Lamichhane Samiksha , Bhola Harsha , Bhalla Tajinder 
Published: March 2024

Key Clinical MessageMigration of any foreign body can cause potentially life threatening complications and should be reviewed by a multidisciplinary approach for the management. Diagnosis can be challenging; a history of foreign body injury could be suspicious.AbstractForeign body injury to the chest wall can be an emergency situation and require a multidisciplinary approach for the management of the condition. Migration of the foreign body, though rare, can lead to potentially life threatening complications and require a multidisciplinary approach for the localization of the foreign body and subsequent management of the condition. A 50‐year‐old male presented to the emergency department with the complaint of left sided chest pain. Upon examination, the patient was found to have a penetrating injury 6 years back by a sharp object. Radiological investigations helped in the localization of the migrating foreign body, which was removed with effective surgical intervention. The postoperative chest x‐ray was normal, the patient was asymptomatic and thus the patient was discharged on the same day following surgery.
Massive hemoptysis with end stage renal disease (ESRD): An initial symptom of rare disease
Authors: Saowapa Sakditad , Chaisrimaneepan Nattanicha , Adu Yaw , Thongpiya Jerapas , Yingchoncharoen Pitchaporn , Bell Amanda L. , Polpichai Natchaya , Siladech Pharit , Payne J. Drew 
Published: March 2024

Key Clinical MessageMicroscopic polyangiitis is a rare autoimmune vasculitis, that could present with renal‐pulmonary symptoms, posing diagnostic challenges in patients with preexisting kidney disease. Timely diagnosis is crucial to improve patient outcomes.
Laparoscopic transhiatal en‐mass thoracic duct ligation for persistent bilateral spontaneous Chylothorax: A case report
Authors: Deo Kunal Bikram , Deo Sumit Kumar , Gautam Sujan , Pandit Narendra , Adhikary Shailesh 
Published: March 2024

Key Clinical MessageChylothorax is a rare entity associated with morbidity. Surgical thoracic duct ligation (TDL) by thoracoscopic approach is the recommended choice for persistent chylothorax. However, thoracoscopy is not feasible in case of previous pleurodesis. We describe a successful laparoscopic transhiatal en‐mass TDL in a 61‐year‐old lady for persistent spontaneous chylothorax after failed optimal conservative management and three sessions of pleurodesis. The study shows that laparoscopic transhiatal thoracic duct ligation is an effective alternative in a case where thoracoscopy is not feasible due to various reasons.
Cardiac mass as the primary diagnostic clue of Edheim–Chester disease
Authors: Alizadehasl Azin , Salehi Maryam Mohseni , Soltani Zeinab , Roudbari Soudeh , Akbarian Mahsa , Mohebbi Somaye , Salehi Pegah 
Published: March 2024

Key Clinical MessageWe introduced one of the rare causes of intra‐cardiac mass, that is, ECD and a new gene mutation (SLC29A3) that is probably related to this disease, and we noted the importance of using several diagnostic methods to rule out other intra‐cardiac causes.AbstractEdheim–Chester disease is a rare histiocytosis affecting multiple organs. The infiltration of lipid‐laden histiocytes characterizes the disease. Most patients experience bone involvement; over 50% of cases involve the cardiovascular system and other extra‐osseous organs. In this case report, we present the case of a 42‐year‐old man who complained of shortness of breath and bone pain. During echocardiography, a large, homogenous, and fixed mass was found in the right atrium free wall. Computed tomography and cardiac magnetic resonance imaging revealed an infiltrative mass in the RA with atrioventricular groove involvement but coronary sinus encasement, right coronary artery, and superior vena cava encasement. Abdominal CT scans also reported aortic wall involvement and bilateral renal cortical and perirenal involvement. A kidney biopsy confirmed the infiltration of histiocytes and the diagnosis of ECD. The treatment was initiated for him, and his symptoms improved. In this case report, we express the importance of considering the rare causes of cardiac tumors.
Cryoglobulinemia vasculitis associated with adult‐onset Still's disease
Authors: Nakagawa Noriharu , Fujii Ai , Ueda Yoshimichi , Yamazaki Masahide 
Published: March 2024

Key Clinical MessageThe present case indicates that cryoglobulinemia vasculitis should be considered in the differential diagnosis of purpura in patients with adult‐onset Still's disease (AOSD).AbstractThe presence of purpura is suggested in adult‐onset Still's disease (AOSD) hematological complications of hemophagocytic syndrome, disseminated intravascular coagulation, or thrombotic microangiopathy. We herein report a case of AOSD complicated by cryoglobulinemia vasculitis presenting with purpura.
Cell‐free DNA‐associated multi‐feature applications in cancer diagnosis and treatment
Authors: Zhang Xiaolu , Li Jingwei , Lan Xun , Li Jie 
Published: March 2024

AbstractMalignant tumours pose significant challenges in terms of high morbidity and mortality rates, primarily due to the lack of large‐scale applicable screening methods and efficient treatment strategies. However, the development of liquid biopsies, particularly circulating cell‐free DNA (cfDNA), offers promising solutions characterised by their non‐invasiveness and cost‐effectiveness, providing comprehensive tumour information on a global scale. The release of cfDNA is predominantly associated with cell death and turnover, while its elimination occurs through nuclease digestion, renal excretion into the urine and uptake by the liver and spleen. Extensive research into the biological properties of cfDNA has led to the identification of novel applications, including non‐invasive cancer screening, cancer subtype classification, tissue‐of‐origin detection and monitoring of treatment efficacy. Additionally, emerging fields such as methylation‐omics, fragment‐omics and nucleosome‐omics show immense potential as tissue‐ and disease‐specific markers. Therefore, this review aims to comprehensively introduce the latest detection techniques of cfDNA, along with detailed information on its characteristics and applications, providing valuable insights for cancer diagnosis and monitoring, which will assist us in purposefully enhancing relevant features for a more comprehensive application in clinical practice.
Outage of cooperative NOMA with an energy harvesting relay in an underlay cognitive radio network
Authors: Ghosh Priyanka , Dhar Roy Sanjay , Kundu Sumit 
Published: March 2024

SummaryThis paper analyzes the performance of a cooperative nonorthogonal multiple access (NOMA) in an underlay cognitive radio network aided by an energy harvesting relay. A secondary source transmits signal for two users, where a near user acts as a relay for the far user. The far user applies the selection combining (SC) approach on the signals which were relayed by the near user and received via direct path from the secondary source. We analytically derive the outage probability (OP) of each user separately, the overall system OP, and the throughput of the system. The impact of the power allocation coefficient of NOMA and energy harvesting parameters on outage is indicated. Further, the performance of the network is investigated with imperfection in successive interference cancellation (SIC), maximal ratio combining (MRC) at relay, and Nakagami‐m fading. The results derived analytically are supported by simulation in MATLAB.
Weight telemonitoring of heart failure versus standard of care in a real‐world setting: Results on mortality and hospitalizations in a 6‐month nationwide matched cohort study
Authors: Roubille François , Mercier Grégoire , Lancman Guila , Pasche Hélène , Alami Sarah , Delval Cécile , Bessou Antoine , Vadel Jade , Rey Amayelle , Duret Stéphanie , Abraham Emilie , Chatellier Gilles , Durand Zaleski Isabelle 
Published: March 2024

ABSTRACTAimsEvaluating the benefit of telemonitoring in heart failure (HF) management in real‐world settings is crucial for optimizing the healthcare pathway. The aim of this study was to assess the association between a 6‐month application of the telemonitoring solution Chronic Care Connect™ (CCC) and mortality, HF hospitalizations, and associated costs compared with standard of care (SOC) in patients with a diagnosis of HF.Methods and resultsFrom February 2018 to March 2020, a retrospective cohort study was conducted using the largest healthcare insurance system claims database in France (Système National des Données de Santé) linked to the CCC telemonitoring database of adult patients with an ICD‐10‐coded diagnosis of HF. Patients from the telemonitoring group were matched with up to two patients from the SOC group based on their high‐dimensional propensity score, without replacement, using the nearest‐neighbour method. A total of 1358 telemonitored patients were matched to 2456 SOC patients. The cohorts consisted of high‐risk patients with median times from last HF hospitalization to index date of 17.0 (interquartile range: 7.0–66.0) days for the telemonitoring group and 27.0 (15.0–70.0) days for the SOC group. After 6 months, telemonitoring was associated with mortality risk reduction (hazard ratio [HR] 0.71, 95% confidence interval [CI] 0.56–0.89), a higher risk of first HF hospitalization (HR 1.81, 95% CI 1.55–2.13), and higher HF healthcare costs (relative cost 1.38, 95% CI 1.26–1.51). Compared with the SOC group, the telemonitoring group experienced a shorter average length of overnight HF hospitalization and fewer emergency visits preceding HF hospitalizations.ConclusionThe results of this nationwide cohort study highlight a valuable role for telemonitoring solutions such as CCC in the management of high‐risk HF patients. However, for telemonitoring solutions based on weight and symptoms, consideration should be given to implement additional methods of assessment to recognize imminent worsening of HF, such as impedance changes, as a way to reduce mortality risk and the need for HF hospitalizations. Further studies are warranted to refine selection of patients who could benefit from a telemonitoring system and to confirm long‐term benefits in high‐risk and stable HF patients.
A comparison of physiological and perceptual responses to fixed‐power and perceptually regulated cycling with and without blood flow restriction in trained cyclists
Authors: Smith Nathan D. W. , Girard Olivier , Scott Brendan R. , Peiffer Jeremiah J. 
Published: March 2024

AbstractThis study compared physiological and perceptual responses between cycling prescribed using fixed‐power (PWR) and fixed rating of perceived exertion (RPE), when performed with blood flow restricted (BFRPWR and BFRRPE) and unrestricted (CONPWR and CONRPE). Endurance cyclists/triathletes cycled for 10 min in four separate randomized conditions; that is, two methods of prescribed exercise intensity (power at the first ventilatory threshold or RPE matched to CONPWR) combined with two occlusion levels (with BFR or without). Cardiorespiratory and perceptual variables were recorded every 2 min. Blood lactate concentration was measured pre‐, immediately and 2‐min postexercise. Power output during BFRRPE was lower than CONRPE (−13 ± 13%). The greatest physiological and perceptual responses were achieved during BFRPWR. Heart rate during BFRRPE was not different compared with CONPWR, yet was greater than CONRPE (+4 ± 11%). Muscular discomfort during BFRRPE was greater than CONPWR (+43 ± 18%) and CONRPE (+65 ± 58%). Cuff pain was greater during BFRPWR than BFRRPE (+14 ± 21%). Blood lactate concentration was not different between BFRRPE, CONPWR, and CONRPE at any timepoint. The reduction in power (fixed‐RPE trials; BFR minus unrestricted) correlated with changes in the respiratory rate (r = 0.85, confidence intervals [CI] = 0.51, 0.96) and postexercise lactate (r = 0.75, CI = 0.27, 0.93) but not muscular discomfort (r = 0.18, CI = −0.47, 0.71). Cardiorespiratory and metabolic stress, muscular discomfort, and cuff pain likely mediated self‐regulating fixed‐RPE cycling with BFR. While cycling with BFR at a fixed‐RPE resulted in less physiological stress compared to BFRPWR, it still provided a heightened level of physiological stress, with less pain and discomfort. As such, fixed‐RPE can be a suitable alternative for prescribing BFR to trained cyclists.