bluuebunny/crossref_metadata_2025_split huggingface dataset:
Images of hairy Reissner–Nordström black hole illuminated by static accretions
Authors: Meng Yuan , Kuang Xiao-Mei , Wang Xi-Jing , Wang Bin , Wu Jian-Pin 
Published: March 2024

AbstractIn this paper, we investigate the shadow and optical appearance of the hairy Reissner–Nordström (RN) black hole illuminated by two toy models of static accretion. The hairy RN black hole was constructed in the gravitation decoupling approach to describe the deformation of a Schwarzschild black hole due to the inclusion of additional arbitrary source (scalar field, tensor field, fluidlike dark matter, etc.). So it is characterized by the parameters: mass (M), deformation factor ($$\alpha $$
α
), electric charge (Q) and the additional hairy charge ($$l_o$$

l
o

)., differentiating from the case in RN black hole. Though the specific background theory that results in this hairy RN black hole is still tricky, here we shall focus on the novel observable features introduced by the hair of this black hole. First, we find that for the hairy RN black hole, the event horizon, radius of photon sphere and critical impact parameter all increase as the increasings of Q and $$l_o$$

l
o

, but decrease as $$\alpha $$
α
grows. Furthermore, the three characterized parameters are found to have significant effects on the photon trajectories, and shadows as well as images of the hairy RN black hole surrounded by the static accretion disk and spherical accretion, respectively. In particular, both Q and $$l_o$$

l
o

have mutually reinforcing effects on the optical appearance and shadows of the hairy RN black hole, which implies that we may not distinguish the electric charge and hairy charge from the shadow and image of black hole in this scenario. Additionally, because of the competing effects of the charge parameters ($$Q, l_o$$

Q
,

l
o

) and the deviation parameter $$\alpha $$
α
on the observed intensities of brightness, the optical appearance between the hairy RN black hole and RN black hole could have degeneracies, indicating the indistinguishability. Our current results contribute more to the phenomenal aspects which could be helpful to build the background theory of this hairy RN black hole.
Marxism as a Natural Science: Alexander Bogdanov’s Anti-Revisionist Revisionism
Authors: Rowley David G. 
Published: March 2024

Abstract
Discussion of Alexander Bogdanov as a Marxist revisionist has largely centred on his philosophy of being and cognition and on Plekhanov’s and Lenin’s accusation that Bogdanov was an idealist renegade from Marxism. However, the real issue of revisionism at the time was not materialism but determinism: the question of whether socialism would appear by the working of the objective laws of nature or the subjective will of human beings. Bogdanov did indeed revise Marxism, but he did so in order to defend it as a natural science. He conceived of society as a form of life subject to biological laws of nature: the need to assimilate energy from the environment and the need to adapt to the environment in the struggle to survive. He reinterpreted the key elements of scientific socialism – the idea that existence determines consciousness and the labour theory of value – in terms of this worldview.
A Second Apostate?
Authors: Cinemre İlhami Tekin 
Published: March 2024

Abstract
The epithet apostate is one of the most striking terms among symbolic characters of late antiquity. It has been applied to only Iulianus and described his paganist practices. Yet, there is another character from the same era that modern literature has left in the dark. After just seven years of Iulianus’ death, Pap, the Armenian king, was labelled as impious by Armenian sources like the characterization of Iulianus by Roman Christians. Keeping these under consideration, this study aims to re-examine whether Pap could be named as a second apostate and to conclude that this was a unilateral glance.
The Tamma of Azerbaijan in Regional and Imperial Contexts (1228–1261)
Authors: Hope Michael 
Published: March 2024

Abstract
Research on the Mongol conquest of Iran and the Transcaucasus has focused most heavily on the campaigns of Chinggis Khan and his nephew Hülegü, in 1219–1224 and 1256–1260 respectively. Significantly less attention has been given to the nearly four decades that separate these two invasions, during which Mongol control was consolidated by a tamma (garrison) army numbering roughly 30,000 soldiers. This garrison occupied a liminal position on the frontier of the Mongol empire, linking the great khan to regional vassals in Iran, Greater Armenia, Georgia, and eastern Anatolia. This paper will use the history of the tamma to illuminate the web of personal relationships that allowed the Mongol empire to project its authority into the Middle East. It will demonstrate that this network was extremely brittle during the first three decades after Chinggis Khan’s death, during which time the Mongol empire was still taking shape. Founded by Chinggis Khan, the tamma owed its loyalty to the great khan in Mongolia, yet long interregnums and political instability at the heart of empire forced the Mongol garrison to identify regional princes and princesses as suitable substitutes for political authority. This collaborative approach embroiled the tamma in the factional politics at the heart of the Mongol empire and ultimately brought about its destruction in 1261.
Heightened Smuggling of Weapons and Ammunition from Southern Caucasus to Northwestern Iran on the Eve of World War I
Authors: Shahvar Soli 
Published: March 2024

Abstract
Documents newly found in the Historical Archives of Azerbaijan Republic reveal that as early as 1912 Ottoman agents were engaged in attempts to entice the Transcaucasian Muslims against Russia and prepare them for the war, which would break out a year-and-a-half later, namely the First World War. Ottomans encouraged the smuggling of Russian weapons and ammunition to regions bordering the Southern Caucasus, especially Northwestern Iran, counting on the sympathy of the Turkophones therein against the Russians, or on their antagonism towards the presence of Russian forces in their own territories. The heightened smuggling of Russian weapons and ammunition alarmed the Russian authorities who began looking into the cases of smugglings in an attempt to prevent or minimize them. Their findings, as expressed in their correspondences, pointed towards an extensive smuggling network headed by an Iranian émigré named Karbalāʾī who ran it with members of his own family and in collaboration with a number of Russian officials.
The Friend, the Eccentric, and the Grouch
Authors: Watts Edward 
Published: March 2024

Abstract
Historians of philosophy are often challenged to discern the relative impacts of the ideas and the actions of ancient philosophers. The ideas of these thinkers often stand alone in an almost disembodied fashion, set apart from the physicality of a philosopher, his or her personality, and even their intellectual development over time. This article considers the tension between the people, the ideas, and the social context in Late Antique Athens and Alexandria and investigates the way in which genial and difficult personalities influence the fate of Neoplatonic schools in the two cities in the late fifth and early sixth centuries AD.
العلاقات التصوّريّة ما بين الإسقاط والتكثيف: دراسة تطبيقيّة في الروابط العرفانيّة القاعديّة المنشئة للثراء الدلاليّ
Authors: غنيم أميرة 
Published: March 2024

الملخّص
‫يسعى هذا البحث، استنادًا إلى الجهاز المفاهيميّ لنظريّة المزج التصوّريّ، إلى الكشف عن الآليّات العرفانيّة القاعديّة التي ينشأ بفضلها الثراء الدلاليّ. فسنحاول، من خلال الاشتغال على مدوّنة تطبيقيّة، أن نقتفي أثر الدلالة وهي تُبنى في الذهن آنَ المعالجة مستدلّين على أنّ بناءها على تلك الصورة تُسيّره مبادئُ بسيطةٌ ذات واقعيّة نفسيّة حدسيّة جرّدتْها على امتداد التاريخ الثقافيّ تجربتنُا البشريّة وأتاحها نظامنا العصبيّ البيولوجيّ. تتمثّل هذه المبادئ في مجموعة من العلاقات التصوريّة التي يسمّيها منوال الشبكة علاقات حيويّة. تتميّز هذه العلاقات بعموميّتها وإنتاجيّتها وانطباقها النسقيّ وتتميّز بمرونة كبيرة تتيح لها التفاعل فيما بينها بفضل ما للذهن من قدرة على الإسقاط الانتقائيّ من جهة والتكثيف التصوّريّ من جهة أخرى، ممّا سيحاولُ التحليلُ التطبيقيُّ بيانَه.‬
Delayed vs Early Admission to Intensive Care: A Retrospective Review of Outcomes and Clinical Indicators of Deterioration Following Trauma
Authors: Rhoton Emily , Bethurum A.J. , King Sarah , Smith Lou M. 
Published: March 2024

Unplanned admission to an intensive care unit (ICU) is a trauma quality improvement indicator associated with increased morbidity, mortality, and hospital resource usage. We identified demographics, injuries, and other clinical factors between early ICU admission, <72 hrs after admission (EAd), and delayed admission, >72 hrs (DelAd) from a medical/surgical floor. 146 trauma patients admitted to ICU at a level 1 trauma center from January 2020 to March 2023 met inclusion criteria and were divided into EAd and DelAd. No statistical differences in injury mechanism or severity were observed. Delayed admission demonstrated higher mortality ( P = .001), more frequent decline in GCS ( P = .045), and initiation of anticoagulation ( P = .002). Abnormal EKG, orthopedic surgery during admission, and home anticoagulant and antidepressant use were statistically significant in identifying patients requiring early ICU admission.
Impact of patient-specific factors on clozapine metabolism in individuals with treatment-resistant schizophrenia or schizoaffective disorder
Authors: Rafizadeh Reza , Sooch Anmol , Risi Alessia , Bihelek Nicoline , Kanegawa Kyler , Barr Alasdair M , White Randall F , Schütz Christian G , Bousman Chad A 
Published: March 2024

Background: There is high inter-individual variability in clozapine metabolism due to genetic and non-genetic differences. Patient-specific factors such as smoking, inflammation indicated by elevated C-reactive protein (CRP), and certain concurrent medications have a significant influence on clozapine metabolism. Aim: To assess which patient-specific factors best explain variability in clozapine metabolism estimated by clozapine concentration to dose (C/D) ratios. Methods: A retrospective cohort analysis using electronic medical data was conducted on 172 inpatients at the BC Psychosis Program. Patients with normal renal and liver function were included if they were on clozapine and had at least one steady-state plasma concentration. The degree of influence of each factor on the variability of clozapine metabolism in the entire cohort and subgroups stratified by fluvoxamine use was evaluated using multiple linear regression analysis of C/D ratios. Results: Model fit testing showed that the entire cohort model accounts for 52.7% of C/D ratio variability, while the no fluvoxamine and fluvoxamine models accounted for 40.8% and 43.8%. In the entire cohort ( n = 172), fluvoxamine use explained the highest variance, and C/D ratios were higher by 30.6% on average. The second strongest predictor was elevated CRP > 10 mg/L, and C/D ratios were higher by 22.9% on average. Subsequently, obesity, nonsmoker status, and female sex explained a significant but modest proportion of variance. Among participants on fluvoxamine ( n = 58), only fluvoxamine dose was associated with an increase, and for every 25 mg increase in dose, C/D ratios increased by 5% on average. Conclusion: In a clinical population, this study replicated the relationship between reduced rate of clozapine metabolism and the use of fluvoxamine, elevated CRP, obesity, nonsmoking status, and female sex; and the magnitude of the effects were large enough to be clinically relevant.
Construction of an oxidative stress-associated genes signature in breast cancer by machine learning algorithms
Authors: Hu Daojun , Qin Bing , Zhang Li , Bu Hanli 
Published: March 2024

Objective To construct a prognostic model of a breast cancer-related oxidative stress-related gene (OSRG) signature using machine learning algorithms. Methods The OSRGs of breast cancer were constructed by least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression analysis. The Cancer Genome Atlas (TCGA) was used to analyse the gene expression and prognostic value. The Human Protein Atlas was used to analyse the protein expression of hub genes. Receiver operating characteristic analysis, calibration curve and decision curve analysis were used to predict the stability of this model. Results The area under the curve of 1-, 3- and 5-year overall survival were 0.751, 0.707 and 0.645 in the TCGA training dataset; and 0.692, 0.678 and 0.602 in the TCGA testing dataset, respectively. Calibration plot showed good agreement between predicted probabilities and observed outcomes. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Enrichment Analysis (GSEA) pathway analysis indicated that multiple cancer-related pathways were highly enriched in the high-risk group. Immune infiltration analysis showed immune cells and their functions may play a key role in the development and mechanism of breast cancer. Conclusions This new OSRG signature was associated with the immune infiltration and it might be useful in predicting the prognosis in patients with breast cancer.
Reinjury Anxiety and Return to Sport After Anterior Cruciate Ligament Reconstruction: A Cluster Analysis and Prospective Study Among 162 Athletes
Authors: Caumeil Benjamin , Laboute Eric , Verhaeghe Emmanuel , Pérez Sébastien , Décamps Greg 
Published: March 2024

Background: Recent studies have investigated the effect of psychological factors on return to sport (RTS), but none has tested the existence of psychological profiles linked to reinjury anxiety and its links with RTS and reinjury. Purpose: To assess the effect of different psychological profiles on RTS and reinjury. Study Design: Cohort study; Level of evidence, 2. Methods: The study screened patients who were involved in all types of sports for anterior cruciate ligament (ACL) reconstruction (hamstring and patellar tendon autografts). All participants were included during the RTS phase (90-180 days after ACL reconstruction). Reinjury anxiety, fear of reinjury, kinesiophobia, perceived stress, anxiety, depression, knee confidence, self-esteem, optimism, coping, and pain were measured. Hierarchical cluster analysis (Ward method) and analysis of variance were performed. In the second year after surgery, patients were recontacted by telephone to follow-up. RTS and reinjury were compared by profile type. Results: A total of 162 athletes were initially included, of whom 123 responded regarding RTS and reinjury. Cluster analysis showed a 4-cluster solution (χ2[21] = 428.59; λ = .064; P < .001). Profile 1 (27.8%) was characterized by moderate reinjury anxiety and no depression. Profile 2 (22.8%) was characterized by moderate reinjury anxiety and minor anxious-depressive reaction. Profile 3 (30.9%) was characterized by no reinjury anxiety, no depression, and high confidence. Profile 4 (18.5%) was characterized by high anxiety, high depression, and low confidence. Profile 4 had the lowest self-esteem and optimism scores compared with profile 3 ( P < .001). In addition, a higher percentage of men was found in profile 3 as opposed to profile 4 (χ2[3] = 11.35; P < .01). Profile 4 had the highest rate of non-RTS with 54.2% (profile 1: 14.3%, P = .001; profile 2: 25.0%, P = .031; profile 3: 22.2%, P = .011). Finally, patients with profile 3 had a higher risk of reinjury (13.9%) than those with profile 4 (0%) ( P = .047), who had an extremely conservative RTS. Conclusion: The different profiles will affect RTS, but also the risk of reinjury exclusively for profiles 3 and 4. Rehabilitation management will probably require all stakeholders to understand psychological profiles of athletes to develop an on-demand rehabilitation plan.
Relationship between vitamin D receptors gene polymorphism and arteriogenic erectile dysfunction
Authors: Elshahid Ahmed Rashad , Zaky Amr Mohamed , Goda Yasser Mamdouh Hasanein , Ismail Nabil Fathy 
Published: March 2024

Background: Over the past few decades, a number of studies have linked vitamin-D deficiency with ED (Erectile dysfunction) risk factors. There is a clear correlation between VD (vitamin-D) levels and ED, according to observational and interventional researches that have been reported in the literature. This crucial information encouraged scientists to investigate the impact of VD on erectile function in greater detail. The fact that vitamin D is a component of a healthy penis that begins in early life has just come to light, however there haven’t been many research looking at the connection between vitamin D receptor gene polymorphism and erectile dysfunction. Objective: To evaluate the relationship between arteriogenic erectile dysfunction and the vitamin D receptor gene polymorphism. Subjects and Methods: Between October 2022 and October 2023, at Al-Azhar University Hospitals, 40 patients with arteriogenic ED and 40 healthy controls underwent informed consent, a detailed history, a physical examination, a penile duplex ultrasound and the extraction of peripheral blood to determine the type of polymorphism for each of the vitamin D receptors: FokI, BsmI, ApaI and TaqI by polymerase chain reaction (PCR). Results: There is no statistically significant association between arteriogenic erectile dysfunction and the vitamin D receptors (VDR) gene polymorphisms FokI, BsmI, ApaI and TaqI. Conclusion: Since there is no statistically significant association between the polymorphism of the vitamin D receptor (VDR) gene and arteriogenic erectile dysfunction, it is advised to investigate other VDR gene polymorphisms as well as alternative clinical subtypes of erectile dysfunction.
Impact of IL-10 gene promoter polymorphisms on treatment response in HCV patients: A systematic review, a meta-analysis, and a meta-regression
Authors: Dhaouadi Tarak , Riahi Awatef , Ben Abdallah Taïeb , Gorgi Yousr , Sfar Imen 
Published: March 2024

The impact of interleukin-10 (IL-10) gene promoter polymorphisms (SNPs) on treatment response in HCV patients was dissimilarly estimated. Hence, the aim of this meta-analysis was to robustly assess the effect of IL-10 SNPs on treatment response in HCV patients. An electronic literature search was carried out through PubMed, EMBASE, Web of science, and Scopus databases. Studies assessing the association between IL-10 polymorphisms and treatment response in HCV patients were included. Studies were excluded if genotype frequencies are not consistent with the Hardy–Weinberg Equilibrium (HWE) or in case of including patients with hepatitis B virus coinfection. Risk of bias in included studies was assessed using the Newcastle–Ottawa Scale. Meta-analyses were performed for the influence of IL-10 gene promoter SNPs (rs1800896 (-1082 A/G), rs1800871 (-819 C/T), and rs1800872 (-592 C/T)) and haplotypes on treatment response in HCV patients. Subgroup analyses, meta-regressions, publication bias assessment, and sensitivity analyses were also conducted. Overall, 32 studies with a total of 5943 HCV cases and 2697 controls were included in the present study. The -1082*G allele was significantly associated with increased risk of non-response (NR) to treatment, OR [95% CI] = 1.29 [1.1–1.51], p = .002. Besides, the rs1800872 -592*C allele was significantly associated with increased NR risk, OR [95% CI] = 1.22 [1.02–1.46], p = .03. Subgroup analysis showed that this association remained significant only in patients treated with PEG-IFN alone, p = .01. The -1082*G/-819*C/-592*C (GCC) haplotype was significantly associated with increased NR risk, OR [95% CI] = 1.62 [1.13–2.23], p = .009. Our results suggest that the IL-10 rs1800896 was associated with NR risk especially in North-African and Asian populations. Moreover, the IL-10 gene promoter -1082*G/-819*C/-592*C (GCC) haplotype which has been associated with higher production of IL-10, was significantly associated with increased NR risk.
Resveratrol Suppresses “Metabolic Memory” by Inhibiting Inflammation and Apoptosis Through the ROS/TXNIP/NLRP3 Signaling Pathway
Authors: Jiang Tingting , Gu Junxiang , Chang Qing 
Published: March 2024

Aim This research endeavored to explore the impact and underlying mechanisms of resveratrol on the phenomenon of “metabolic memory” in cultured human retinal vascular endothelial cells (HRVECs) under high-glucose (HG) conditions. Materials and Methods According to the glucose level and treatment, cultured HRVECs were divided into seven groups: normal glucose (NG), HG, high glucose followed by NG (HN), mannitol (Man), resveratrol, thioredoxin-interacting protein (TXNIP)-small interfering ribonucleic acid (siRNA), and N-acetylcysteine (NAC). The expression levels of TXNIP, nucleotide oligomerization domain (NOD)-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, intercellular adhesion molecule 1 (ICAM-1), caspase-1, interleukin-1β (IL-1β), B-cell lymphoma 2 (Bcl-2), caspase-3, and Bcl-2-associated X (BAX), as well as reactive oxygen species (ROS) production, were measured. Cell apoptosis was assessed through a terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay. Results In HRVECs from the HG group, expression levels of TXNIP, NLRP3, caspase-1, ICAM-1, and IL-1β were upregulated. However, in the HN group, the above upregulations were not reversed. After the administration of resveratrol, the expression levels of TXNIP, NLRP3, and other inflammatory cytokines were significantly reduced. Resveratrol mitigated the elevated ROS production induced by HG conditions. In the NAC group, the expression of TXNIP and inflammatory cytokines was downregulated. TXNIP-siRNA treatment showed similar effects. Resveratrol inhibited apoptosis as well as reversed the downregulation of BCL-2 and the upregulation of caspase-3 and BAX induced by HG conditions. Conclusion Resveratrol mitigated the HG-induced phenomenon of “metabolic memory” by inhibiting inflammation and apoptosis via modulation of the ROS/TXNIP/NLRP3 signaling pathway in cultured HRVECs. Therefore, resveratrol may have therapeutic potential to treat diabetic retinopathy and related metabolic memory complications.
A national mental health cascade training programme for practitioners supporting unaccompanied minors in Greece
Authors: Vostanis Panos , Sofios Panagiotis , Petrali Alexandra , O’Reilly Michelle 
Published: March 2024

Background Practitioners who support unaccompanied minors (UAMs) come from different professional backgrounds and often are not appropriately trained to address children’s complex mental health needs. This gap informed a training programme across all accommodation centres in Greece. Methods The aim of the Train-of-Trainer (ToT) national programme was to upskill trainers from 17 organisations to cascade knowledge. Training was interprofessional, trauma-informed and culturally sensitive. A pilot implementation involved 199 practitioners from all disciplines. A sub-sample of 33 practitioners, nine managers and six trainers shared their experiences in focus group discussions, which were analysed through a thematic framework. Results Participants found that the programme was useful in generating knowledge relevant to children’s needs and their roles, addressing the emotional impact of trauma on staff, sharing learning across professional disciplines and being interactive, but systemic support should be put in place for benefits to be sustained. Conclusions Train-of-Trainer is a resource-effective approach to upskill mixed staff groups across many organisations. This should involve caregivers and staff with limited educational opportunities, while accommodating for different professional needs. Training should be integrated to service budgets, specifications and structures.