bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neoadjuvant chemotherapy in marginally resectable stage III M0 non‐small cell lung cancer: Long‐term follow‐up in 41 patients
Authors: Skarin Arthur , Jochelson Maxine , Sheldon Thomas , Malcolm Arnold , Oliynyk Peter , Overholt Richard , Hunt Myla , Frei Emil 
Published: February 2007

AbstractForty‐one patients with marginally resectable stage III M0 non‐small cell lung cancer (NSCLC) were entered into a study evaluating neoadjuvant cyclophosphamide, adriamycin, and cisplatin chemotherapy (CAP) followed by radiotherapy and subsequent resection. Postoperative radiotherapy and additional CAP were also administered. The objective disease regression rate prior to surgery was 72% (2 complete, 12 partial, and 7 minimal responses). Thoracotomy was carried out in 37 patients (90%), with resection of all gross disease in 36 patients (97%). Relapse occurred in 22 (61%) of the resected patients, involving chest only (four patients), chest and extra thoracic (nine patients), and extra thoracic only (nine patients). Subsequent CNS relapse developed in 9 (25%) of 36 postop patients in association with other sites of relapse (five patients) or as a solitary location (four patients). Only one of seven patients receiving prophylactic cranial irradiation (PCI) developed CNS relapse compared with 7 (26%) of 27 patients not receiving PCI. The median long‐term follow‐up for 14 living patients is 53 + months, with a range of 38 + to 71 + months. Median survival for all patients is 32 months, with 1‐year survival being 75%. The survival curve shows a plateau of 31% from 3 to 5 + years. Using a log rank test, no prognostic subgroups could be identified that significantly affected response rate, disease‐free survival, or overall survival. While neoadjuvant CAP followed by radiotherapy appears to improve survival, more effective chemotherapy along with randomized studies are needed to determine the role of initial chemotherapy in marginally resectable NSCLC.
Lung resection for metastatic sarcomas: Total survival from primary treatment
Authors: Pastorino Ugo , Valente Maurizio , Gasparini Marco , Azzarelli Alberto , Santoro Armando , Alloisio Marco , Ongari Mauro , Tavecchio Luca , Ravasi Gianni 
Published: February 2007

AbstractThe results of surgical management of 63 cases of pulmonary metastases from bone and soft tissue sarcomas, admitted at the Istituto Nazionale Tumori of Milan, between 1970 and 1987, are reviewed in this paper. To estimate the relative impact of metastasectomy on the overall performance of treatment, survival curves were calculated from the time of first thoracotomy, as well as from the initial treatment of primary sarcoma. In the present series, total actuarial survival at 10 years was 37% for osteosarcoma, 27% for soft tissue sarcomas, and 24% for the other bone sarcomas, with a median survival of 48, 56, and 36 months, respectively. Five‐year survival from the first pulmonary resection was influenced by the number of metastases and the length of the first disease‐free interval only in osteosarcoma, while in soft tissue sarcomas a major untoward factor was represented by local recurrence at the site of the primary tumor. These data support the concept of pulmonary metastasectomy as effective salvage therapy for radically treated sarcomas; this management can rescue a significant proportion of all relapsed patients.
Study of cell kinetics in anaplastic thyroid carcinoma transplanted to nude mice
Authors: Yoshida Akira , Fukazawa Masakatu , Ushio Hiroki , Aiyoshi Yuji , Soeda Shugo , Ito Kunihiko 
Published: February 2007

AbstractThe cell kinetics of the transplantable human anaplastic thyroid carcinoma were studied in athymic nude mice using bromodeoxyuridine (BrdU) pulse labeling. In order to estimate the cell cycle time in this study, the percent labeled mitosis curve was prepared with immunoperoxidase staining using monoclonal antibody to BrdU instead of 3[H]thymidine autoradiography. This technique was considered to be very useful because it can be done for a short term and can still be changed to the autoradiographic method.Comparing the results in this study with already reported data on various xenografts of human carcinomas in nude mice, the tumor doubling time (117.5 hr) and the cell cycle time (23.5 hr) were rather short, but the growth fraction (54%) and the cell loss factor (68%) were nearly equivalent to the median value.These findings suggest that the very rapid growth rate of this tumor was mainly due to the shortness of the cell cycle time.
Positivity to glial fibrillary acidic protein in bone, cartilage, and chordoma
Authors: Kasantikul Vira , Shuangshoti Samruay 
Published: February 2007

AbstractTwenty vertebral bones, 11 costal, 11 epiglottic, six tracheal, and five bronchial cartilages and seven chordomas were evaluated by the application of peroxidase‐antiperoxidase (PAP) indirect immunohistochemical method for localization of glial fibrillary acidic protein (GFAP). Positive immunostaining for GFAP was observed in osteocytes of normal bone (13/20), chondrocytes of normal epiglottis (5/11), costal cartilage (3/11), trachea (2/6), and bronchus (4/5). Four of seven chordomas had neoplastic cells that exhibited cytoplasmic positivity to GFAP. These findings suggested that osteocytes, chondrocytes, and chordoma cells have cytoskeletal intermediate filaments that are antigenically identical to or similar to or associated with GFAP.
Implantable catheter system for long‐term intravenous chemotherapy
Authors: Hall Per , Cedermark Björn , Swedenborg Jesper 
Published: February 2007

AbstractFifty‐three implantable catheter systems (Port‐A‐Cath) were placed subcutaneously in 48 patients with malignant tumours. This device consists of a stainless steel chamber covered by a silicone membrane connected to a silicone catheter placed in a central vein. All systems were used for administration of chemotherapy. The mean function time was 187 days (range 0‐867). Complications necessitating reoperation occurred in six patients. In three cases, the catheter occluded from thromboses. In two patients, wound dehiscence occurred, and in one a wound infection developed. In one case, the catheter was disconnected from the port. Four patients who had had the port removed later received new ports. One patient had the second port removed and was given a third catheter system. It is concluded that subcutaneously implantable injection ports constitute a safe and convenient access for long‐term intravenous chemotherapy. The complication rate is low, and it should be possible to avoid most recorded complications in the future.
Massive intraoperative atelectasis secondary to untreated mediastinal Hodgkin's disease: Report of the hazard and review of the literature
Authors: Merrick Hollis W. , Martin John T. , Woldenberg Lee S. , Driscoll Peter L. 
Published: February 2007

AbstractMediastinal adenopathy in Hodgkin's disease has been known to cause relative airway compromise, particularly in the more vulnerable left mainstem bronchus. This has been infrequently reported to occur during general anesthesia and to cause respiratory embarrassment, representing a significant hazard. The possibility of its occurrence should be recognized. Preoperative evaluation of the airway by chest films and tomography, followed by radiation therapy in those patients at risk, is recommended to minimize the chances of respiratory complications during general anesthesia.
Clinical and experimental studies on a midgut carcinoid tumor
Authors: Åhlund L. , Kindblom L. G. , Nilsson O. , Skolnik G. , Tylén U. , Dahlström A. , Ahlman H. 
Published: February 2007

AbstractThis study reports on a patient with a midgut carcinoid discovered due to the occurrence of a subcutaneous metastasis that caused symptoms. The histopathologic diagnosis of a carcinoid was confirmed by light and electron microscopic and immunocytochemical examination of the metastasis. The primary ileal tumors were only localized after the determination of serotonin in platelet‐poor plasma/whole blood sampled at selective mesenteric vein catheterization. Tumor cells from lymph node metastases were studied in vitro, in intraocular heterotransplants, and in cell culture.
CEA and CA 19‐9 in benign pulmonary or mediastinal cystic lesions
Authors: Uyama Tadashi , Monden Yasumasa , Sumitomo Masayuki , Miura Kazumasa , Kimura Suguru 
Published: February 2007

AbstractSerum carbohydrate antigen (CA) 19‐9 was present at high levels in pulmonary sequestration, mediastinal bronchogenic cysts, and mediastinal mature teratomas. The fluid in the cysts of the lesions contained a high level of CA 19‐9. After operation, the titer of serum CA 19‐9 returned to normal ranges. Histological studies showed that mucosal epithelium stained positively for CA 19‐9. We speculate that CA 19‐9 concentrated in the cystic lesion might flow into the peripheral blood. Carcinoembryonic antigen (CEA) was also present at high levels in the cyst fluid. CEA was positively stained in the epithelial cells using a polyclonal antibody but not a monoclonal antibody. The CEA detected at high concentration in the fluid was considered to be immunologically cross‐reacting CEA.
Infiltrating lobular carcinoma of the breast treated with segmental and modified radical mastectomy
Authors: Martin Michael A. , Welling Richard E. , Strobel Stephen L. 
Published: February 2007

AbstractConservative treatment of infiltrating lobular carcinoma (ILC) has previously been examined only in terms of general breast carcinoma studies. However, this lesion has been shown to differ from the more common infiltrating ductal carcinoma (IDC) in estrogen receptor (ER) status, metastatic patterns, and bilaterality. Therefore, it is necessary for the physician to consider these distinctions when planning both pre‐ and post‐operative treatment. To determine the effectiveness of both segmental and modified radical mastectomies, the medical records of 26 patients with ILC were reviewed, and follow‐up information was obtained. In addition to surgical treatment, hormonal manipulation and/or radiotherapy were used when appropriate. We found the results of a conservative approach in the treatment of this disease to be comparable to the more radical procedures with respect to overall survival and disease‐free intervals. The single factor that most affected a patient's prognosis was involvement of the axillary nodes.
Pre‐ and postoperative sequential study on the immunosuppressive activity of serum and cell‐free skin bleb fluid of patients with lung cancer and esophageal cancer
Authors: Zhou Qinghua , Yang Zhenhua , Zhang Huaibin , Yang Junjie , Xiao Yuankang 
Published: February 2007

AbstractSerial changes of immunosuppressive activity of serum and cell‐free skin bleb fluid that can suppress the activity of acid a‐naphthyl acetate esterase (ANAE) of lymphocytes and phagocytosis of macrophages were detected by immunoregulatory tests in vitro in 50 lung cancer and 42 esophageal cancer patients. In comparing these tests with those of 53 cases of non‐cancerous thoracic lesion and 69 normal adults, the immunosuppressive activity of serum and skin bleb fluid from cancer patients is significantly higher than that of noncancerous thoracic lesions and normal individuals (P < .01). The activity is related to the stages of cancer, the size of primary tumor, the presence of lymph node metastasis, and tumor resectability, but not to histological classification, sex, and age. The immunosuppressive activity of serum and skin bleb fluid decreased gradually after the removal of the tumor and was eliminated on the 30th postoperative day.These results suggest that serum and skin bleb fluid from cancer patients may contain immunosuppressive factors that can suppress the immune responsive functions of lymphocytes and macrophages in vitro in a manner similar to that seen in vivo. Therefore, complete surgical removal of cancer is likely the most effective immunotherapy.
Effects of combined modality therapy of head and neck carcinoma on shoulder and head mobility
Authors: Nowak Peggyann , Parzuchowski Jeanne , Jacobs John R. 
Published: February 2007

AbstractOne hundred twenty‐six patients were evaluated prospectively for head and shoulder mobility following combined treatment of their advanced head and neck carcinoma. In the absence of a pectoral myocutaneous flap reconstruction, the sacrifice of the spinal accessory nerve does not appear to be deleterious to overall head and shoulder mobility with the exception of shoulder elevation. The addition of the pectoral myocutaneous flap reconstruction negated the shoulder elevation difference between the modified neck dissection and the classical neck dissection. The administration of postoperative radiation therapy appears to decrease the range of motion of both the head and the shoulder by up to 20%. We conclude that head and shoulder mobility following combined modality treatment for patients with head and neck carcinoma appears to be a multifaceted problem involving more than the presence or absence of the accesory nerve and psychosocial considerations. The multifaceted etiology of this problem should be taken into consideration when developing physical and occupational programs directed specifically at this problem.
Partial nephrectomy in mice with milliwatt carbon dioxide laser and its influence on experimental metastasis
Authors: Ammirati Mario , Rao Leela N. , Satya Murthy M. , Buchmann Tamara , Goldschmidt Robert A. , Scanlon Edward F. 
Published: February 2007

AbstractWe have developed a surgical model to perform partial nephrectomy in mice using the milliwatt CO2 laser and have used this model for studying the influence of the sequel of surgery on experimental tumor metastasis. Strain A mice were subjected to partial nephrectomy using the milliwatt CO2 laser. The surgical procedure was time efficient, the blood loss was minimal, and the postoperative mortality was 6%. Immediately after surgery, the wound consisted of a superficial layer of charring and a deeper layer of thermal damage (coagulative necrosis). The wound healing was completed within 30 days and was accompanied by fibroblast infiltration and tubular regeneration but minimal inflammatory response. Seventy surgical mice were injected I.V. with TA3Ha murine mammary adeno‐carcinoma cells at different intervals (immediately to 30 days) after surgery. Among 38 mice inoculated with tumor cells immediately or up to 3 days after surgery, 18 (47%) showed histologically confirmed tumors at the site of surgical trauma. None of the 38 unoperated kidneys showed any evidence of tumor. This difference is statistically significant at a P value of <0.001. As the interval between surgery and tumor inoculation was increased to 7, 15, and 30 days, the frequency of tumor formation at the site of surgery decreased to 20% (2/10), 14% (2/14), and 0% (0/8), respectively. The results demonstrate that a) partial nephrectomy in mice is feasible with minimal mortality or apparent morbidity, b) the laser‐induced surgical trauma favors implantation and growth of tumors, c) the frequency of tumor formation is related to the stage of wound healing, and d) the tumors are anatomically related to the healing wound but do not invade into the parenchymal tissue.
The use of a hand‐held gamma detector improves the safety of isolated limb perfusion
Authors: Sardi Armando , Minton John Peter , Mojzisik Cathy , Nieroda Carol A. , Ferrara Peter J. , Hinkle George H. , Thurston Marlin O. , Martin Edward W. 
Published: February 2007

AbstractWe used two hand‐held gamma‐detecting probes (GDP) (Neoprobe™ 1000 system) capable of detecting small gamma emissions to monitor leakage in patients undergoing hyperthermic isolated limb perfusion (HILP) who received 800 μCi Technetium 99m pentetate through the perfusate. The percentage of gamma‐ray leakage was calculated by a simultaneous reading of two probes at 1‐minute intervals (one over the precordial area and one over the thigh) and this was compared to results of simultaneous blood sampling from the perfusate and systemic circulation at 15‐minute intervals for gamma well counting (GWC). The percentage of leakage recorded by the GDPs was essentially identical to that detected by the GWC (7.3% and 8.2%, respectively at the conclusion of the perfusion). The GDP gives an immediate and accurate indication of the percentage of leakage during HILP, making it a safer procedure.
Urinary polyamine levels in cancer patients treated with D,L‐α‐Difluoromethylornithine, an inhibitor of polyamine biosynthesis
Authors: Horn Yoav , Spigel Lina , Marton Laurence J. 
Published: February 2007

AbstractThe polyamine biosynthesis inhibitor D,L‐α‐Difluoromethylornithine hydrochloride monohydrate (DFMO) has cytostatic and cytotoxic effects against various human tumor cell lines in vitro. We measured levels of the polyamines putrescine and spermidine in the urine of cancer patients undergoing “conventional” chemotherapy in a two‐arm randomized phase I–II study with and without additional DFMO administered orally at a dose of 1.7 g/sq.m. t.i.d. The study group included 38 patients with carcinoma of the breast, stomach, prostate, or female genital organs or metastatic carcinoma of unknown origin. A control group of 32 patients with similar malignancies received “conventional” chemotherapy without DFMO. Polyamine levels were determined periodically in the urine of all patients. In DFMO‐treated patients, a significant decrease in putrescine and spermidine levels was observed after 3 weeks of DFMO therapy (the first time point evaluated) that usually persisted throughout the course of treatment. Significant differences in polyamine levels between DFMO‐treated and control patients were observed for patients in remission. Less significant differences were noted, however, for patients with static or progressive disease between DFMO‐treated and control groups. DFMO activity appears to be reflected by a long‐term decrease in urinary polyamine levels.
Proximal colostomy: Still an effective emergency measure in obstructing carcinoma of the large bowel
Authors: Gutman Mordechai , Kaplan Ofer , Skornick Yehuda , Greif Franklin , Kahn Perry , Rozin Ron R. 
Published: February 2007

AbstractLarge bowel obstruction constitutes an emergency abdominal condition and necessitates prompt surgical treatment. The optimal approach is still controversial as to whether to perform a diverting colostomy only or a tumor resection with or without primary anastomosis. Seventy‐one elderly and high‐risk patients were treated by proximal diverting colostomy through a right upper abdominal incision. The operative mortality was 8.5%, with an additional morbidity of 20.5%. Stomal complications appeared in 6.1% of the survivors. Seventy‐five percent of surviving patients underwent successful resection and closure of colostomy within 3 months without additional mortality. Others were not operated because of metastatic disease or severe concomitant disease. We conclude that although primary resection should be attempted in good risk patients, for those patients who are elderly and at high risk, a simple life‐saving procedure, such as fecal diversion, could alleviate obstructions with relatively low morbidity and mortality and improve the patient's prospects for subsequent definitive surgery.
Spontaneous gastroduodenal perforation in cancer patients receiving cytotoxic therapy
Authors: Ricci John L. , Turnbull Alan D. M. 
Published: February 2007

AbstractSpontaneous gastroduodenal perforation (SGDP) occurs in cancer patients receiving cytotoxic drugs, corticosteroids, or radiation therapy as primary or adjuvant treatment for their tumors. A retrospective review identified 12 patients from 1974 to 1987 at the Memorial Sloan‐Kettering Cancer Center who underwent surgery for SGDP while receiving anticancer therapy.There were five gastric and seven duodenal perforations. Vague abdominal pain was the most common symptom. Exploration was delayed in six patients because of an absence of physical findings. All patients received a Graham omental patch. The in‐hospital operative mortality was 33%, with all major complications occurring in those that died. There were no prognostic indicators identified that would preoperatively predict outcome. Aggressive surgical intervention is advised in all patients who have a reasonable chance of worthwhile palliation if not cure.
Chronic radiation enteritis: A community hospital experience
Authors: Fenner Michael N. , Sheehan Patricia , Nanavati Parashar J. , Ross Donald S. 
Published: February 2007

AbstractA retrospective study was undertaken to evaluate the operative management of patients with chronic radiation enteropathy. Thirty‐eight affected patients from 1974 to 1986 were reviewed. Patients with recurrent cancer responsible for symptoms were excluded. Seventy‐one percent of patients presented with bowel obstruction. Twenty‐one patients were treated with bowel resection, while 17 were treated with a bypass procedure or diverting ostomy alone. Overall morbidity was 45%, and postoperative mortality was 16%. Patients in the bypass group were significantly older than those in the resection group (70.3 vs. 55.5 years, P = .024), suggesting that age may have been a determinant of the procedure performed. In our study there was no difference in outcome based on preexisting vascular disease, tumor site, type of procedure performed, or radiation dose. We conclude that resection is the procedure of choice in cases of chronic radiation enteritis requiring surgery except in cases with dense adhesions when enteroenterostomal bypass is a viable alternative.
Right colon cancer: Long‐term results after curative surgery and prognostic significance of duration of symptoms
Authors: Fegiz G. , Barillari P. , Ramacciato G. , De Angelis R. , Gozzo P. , Indinnimeo M. , Valabrega S. 
Published: February 2007

AbstractBetween 1976 and 1986, a consecutive series of 195 patients with right colon cancer were admitted at the First Department of Surgery of the University of Rome. Patients were divided into five groups according to the absence of intestinal symptoms (group 1) and the duration of the symptomatic phase (groups 2‐5). Analysis of the preoperative investigation showed that colonoscopy was able to identify 33 (26.2%) of tumors misdiagnosed by double contrast X‐ray barium enema. We did not notice any correlation among symptom duration and tumor stage, tumor differentiation, operability rate, and survival. Patients admitted in the asymptomatic phase presented tumors of less advanced stage and, thus, had the best survival rate (71.4%). In this group, patients promptly treated had a better survival rate (87.5%) than those treated after 2 months (50%).Our study suggests that only neoplasms diagnosed in asymptomatic patients and treated promptly are related to a good survival rate. We, therefore, emphasize the importance of education of patients and family physicians about right colon cancer and the necessity to investigate all patients with a suspected right colon cancer by means of colonoscopy.
Use of transrectal ultrasound in detection of prostatic carcinoma: A preliminary report
Authors: Drago Joseph R. , Nesbitt John A. , Badalament Robert A. 
Published: February 2007

AbstractThree hundred twenty patients who were asymptomatic males aged 55‐70 years, were evaluated with transrectal ultrasound in both the axial and sagittal projections to evaluate the efficacy of transrectal ultrasound in detecting early prostatic carcinoma. Thirteen patients had palpable nodules that were positive for prostatic carcinoma, and ten patients had normal rectal examinations but ultrasound abnormalities, which were confirmed with prostate biopsy positive for prostatic carcinoma. This preliminary report points to certain advantages of this screening procedure, but conclusions as to its efficacy must await the results of more extensive trials.