bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain during primary molar local anaesthesia with SleeperOne5 computerized device versus conventional syringe: A randomized, split‐mouth, crossover, controlled trial
Authors: Muller‐Bolla Michèle , Aïem Elody , Joseph Clara , Davit‐Béal Tiphaine , Marquillier Thomas , Esclassan Emmanuelle , Delfosse Caroline , Lopez Serena , Velly Ana Miriam 
Published: April 2024

AbstractBackgroundBecause of controversial results from clinical studies comparing different dental local anesthesia methods in children, the primary objective of this randomized, split‐mouth, crossover, controlled trial was to compare pain intensity during local anaesthesia (LA) performed with a computer‐controlled LA delivery system (C‐CLADS) versus a conventional syringe (CONV). Secondary objectives included comparisons during dental treatment.MethodsParticipants (4–8 years) with tooth pair requiring similar treatment were recruited from five French hospitals. The right primary molar, which was treated at the first visit, was randomly allocated to one of the anaesthesia groups (either intraosseous with C‐CLADS or infiltration with CONV), whereas the contralateral molar (treated at the second visit) was assigned to the other group. Pain intensity and behaviour outcomes, assessed with the Faces Pain and Venham revised scales, respectively, were compared between groups using Proc mixed. Stratified analyses were performed on dentition and location.ResultsAmong 107 participants, the analysis revealed reduced pain perception during LA in the C‐CLADS group compared with the CONV group (−0.72, 95% CI: −1.43, −0.006), but not during dental treatment. Stratified analyses showed that this effect was observed only in primary dentition (p = .006) and mandibular molars (p = .005). Behavioural issues were fewer in the C‐CLADS group than in the CONV group (p = .05) only during injection.ConclusionC‐CLADS emerged as the preferable system in primary dentition.
Adhesive restorations in primary dentition: A retrospective analysis of survival rate and associated factors
Authors: Souza‐Oliveira Ana Clara , Paschoal Marco Aurélio Benini , Rezende Thiago , Alvarenga‐Brant Rachel , Abreu Mauro Henrique Nogueira , Martins‐Pfeifer Carolina Castro 
Published: April 2024

AbstractBackgroundSeveral clinical and individual factors may play a role in the survival rate of dental restorations, such as characteristics related to the child’s age and oral hygiene, and factors associated with the tooth, such as the type of material and number of surfaces to be restored.AimTo analyse the survival rate of adhesive restorations on primary teeth and factors associated with restoration survival.DesignThe study included dental records of children aged 3–12 years having received adhesive restorations on primary teeth at a Brazilian dental school between 2009 and 2019. A Kaplan–Meier survival curve was used to plot survival rates using the log‐rank test. A multivariate Cox regression model was run to identify individual and dental factors associated with restoration failure.ResultsThe sample comprised 269 restored teeth in 111 children. Survival curves were similar for all materials (p = .20) and types of isolation (p = .05). The annual failure rate was 3.60% for glass ionomer cement, 1.23% for resin‐modified glass ionomer cement and 0.40% for composite resin. The following variables were associated with more failures: Class II restoration compared with Class I (HR = 1.96; 95%CI: 1.28–2.99, p < .001), proportion of decayed teeth (HR = 11.89; 95%CI: 2.80–50.57, p < .001) and child's age (HR = 1.17; 95%CI: 1.06–1.29, p < .001).ConclusionThe different materials and types of isolation had similar survival rates. Children with more decayed teeth have an increased risk of restoration failure.
Analysis of risk factors affecting wound healing and wound infection after meningioma resection
Authors: Wang Jianye , Shou Jixin , Gao Haidong , Wang Bingbing , Ding Panfeng , Yang Peng 
Published: April 2024

AbstractTo analyse the risk factors affecting wound healing and infection after spinal meningioma resection surgery. The surgical incision healing of 137 patients who underwent spinal meningioma resection at our hospital from January 2021 to January 2024 was analysed. The data collected included physical examination findings, haematological and biochemical measurements, and various scales assessed upon admission and after surgery. These data were then analysed. The surgical wound healing, infection and postoperative complications were statistically analysed. Multiple logistic regression analysis method was used to conduct risk factor analysis on corresponding indicators; the odds ratio and p value of 95% confidence interval were calculated. Factors such as age and smoking history were significantly negatively correlated with wound healing after meningioma resection (odds ratio < 1.000, p < 0.05), while preoperative albumin and platelet count were significantly positively correlated with wound healing (odds ratio > 1.000, p < 0.05). Age, WHO Meningioma Grading, preoperative albumin and preoperative platelet were significantly negatively correlated with wound infection after meningioma resection (odds ratio < 1.000, p < 0.05). The history of virus infection and history of neurological disorders were significantly positively correlated with wound infection (odds ratio > 1.000, p < 0.05). The influence of each factor is different. Age, smoking history, WHO Meningioma Grading, preoperative albumin, preoperative platelets, history of virus infection and history of neurological disorders had the greatest influence on wound healing and infection after meningioma resection.
Silver nanoparticle dressing: The knowledge of advantages and limits improves the indications in clinical practice
Authors: Budini Valentina , Bassetto Franco , Scarpa Carlotta , Vindigni Vincenzo 
Published: April 2024

AbstractSilver nanoparticle dressings have gained popularity recently as a way to treat challenging wounds. Notwithstanding the properties of Ag‐NPS (silver nanoparticles) described by several articles, there is a lack of clinical studies that guide healthcare professionals to specific and conscious use. In this case series, Ag‐NPS dressing was tested on a randomized group of 10 patients with complex wounds requiring conservative treatment. Each case was analysed, recording the patient's history, the peculiar characteristics and the progressive changes in the wound. The wound bed and the quality of the peri‐wound skin improved and a decrease in signs of infection was observed. The application of the dressing was simple and comfortable for the patient and it was appreciated for its sealing ability. A few capacity restrictions showed up: those should be read as elements to improve the indications for this peculiar dressing. The thin tissue matrix of the Ag‐NPS dressing does not allow for massive absorption and also performs poorly in reducing little exudate. The reduction in wound width is also limited: reconstructive surgery was required in half of the enrolled patients to achieve wound healing.
Controlling the effects of sampling bias in biodiversity models
Authors: Oliveira Ubirajara , Soares‐Filho Britaldo , Nunes Felipe 
Published: April 2024

AbstractAimSampling bias and gaps have a direct influence on the perceived patterns of biodiversity, hence limiting our ability to make well‐informed decisions about biodiversity conservation. Yet most methods either disregard or underestimate the effects of sampling bias and gaps in modelling biodiversity patterns. Our objective is to test the sensitivity of commonly used methods for modelling biodiversity dimensions (richness, endemism, and beta diversity) to sampling bias and collection gaps, and as a way to mitigate those effects we introduce a novel approach that employs the sampling effort to minimize the effects of collection bias and gaps in biodiversity models.LocationSouth America.MethodsHere, we use controlled simulations of virtual species distribution and sampling effort to test the sensitivity to sampling bias and collection gaps by commonly used methods, that is, species distribution models (SDMs), spatial interpolation (SI), and environmental prediction (EP), for estimating species richness, endemism, and beta diversity. Our research contributes to advancing biodiversity modelling by introducing a novel approach, named uniform sampling from sampling effort (USSE), that employs the sampling effort to minimize the effects of collection bias and gaps.Results and Main ConclusionsEP with USSE has proven effective in accurately predicting species richness, especially in scenarios in which the sampling effort does not coincide with the biodiversity niches. It outperformed SI and SDMs. The latter performed poorly, yielding the lowest predictive score. In estimating endemism and beta diversity, all methods yielded similar results, without statistically significant differences. For estimating beta diversity, the generalized dissimilarity model proved to be a robust method, even in face of biased sampling. Controlled simulations are key to testing biodiversity methods. These tests can isolate confounding factors inherent to real‐world data, enabling robust methodological assessments. Although fieldwork and curation of collections must remain indispensable, novel biodiversity methods could help overcome the limitations of sampling biases, helping expedite conservation actions much needed.
Enhanced control of periodontitis by an artificial intelligence‐enabled multimodal‐sensing toothbrush and targeted mHealth micromessages: A randomized trial
Authors: Li Yuan , Wu Xinyu , Liu Min , Deng Ke , Tullini Annamaria , Zhang Xiao , Shi Junyu , Lai Hongchang , Tonetti Maurizio S. 
Published: April 2024

AbstractAimTreatment of periodontitis, a chronic inflammatory disease driven by biofilm dysbiosis, remains challenging due to patients' poor performance and adherence to the necessary oral hygiene procedures. Novel, artificial intelligence‐enabled multimodal‐sensing toothbrushes (AI‐MST) can guide patients' oral hygiene practices in real‐time and transmit valuable data to clinicians, thus enabling effective remote monitoring and guidance. The aim of this trial was to assess the effect of such a system as an adjunct to clinical practice guideline‐conform treatment.Materials and MethodsThis was a single‐centre, double‐blind, standard‐of‐care controlled, randomized, parallel‐group, superiority trial. Male and female adults with generalized Stage II/III periodontitis were recruited at the Shanghai Ninth People's Hospital, China. Subjects received a standard‐of‐care oral hygiene regimen or a technology‐enabled, theory‐based digital intervention consisting of an AI‐MST and targeted doctor's guidance by remote micromessaging. Additionally, both groups received guideline‐conform periodontal treatment. The primary outcome was the resolution of inflamed periodontal pockets (≥4 mm with bleeding on probing) at 6 months. The intention‐to‐treat (ITT) analysis included all subjects who received the allocated treatment and at least one follow‐up.ResultsOne hundred patients were randomized and treated (50 tests/controls) between 1 February and 30 November 2022. Forty‐eight tests (19 females) and 47 controls (16 females) were analysed in the ITT population. At 6 months, the proportion of inflamed periodontal pockets decreased from 80.7% (95% confidence interval [CI] 76.5–84.8) to 52.3% (47.7–57.0) in the control group, and from 81.4% (77.1–85.6) to 44.4% (39.9–48.9) in the test group. The inter‐group difference was 7.9% (1.6–14.6, p < .05). Test subjects achieved better levels of oral hygiene (p < .001). No significant adverse events were observed.ConclusionsThe tested digital health intervention significantly improved the outcome of periodontal therapy by enhancing the adherence and performance of self‐performed oral hygiene. The model breaks the traditional model of oral health care and has the potential to improve efficiency and reduce costs (NCT05137392).
Brain structure and functional connectivity linking childhood cumulative trauma to COVID‐19 vicarious traumatization
Authors: Liu Xiqin , Zhao Yajun , Li Jingguang , Suo Xueling , Gong Qiyong , Wang Song 
Published: April 2024

BackgroundThe COVID‐19 pandemic has caused some individuals to experience vicarious traumatization (VT), an adverse psychological reaction to those who are primarily traumatized, which may negatively impact one's mental health and well‐being and has been demonstrated to vary with personal trauma history. The neural mechanism of VT and how past trauma history affects current VT remain largely unknown. This study aimed to identify neurobiological markers that track individual differences in VT and reveal the neural link between childhood cumulative trauma (CCT) and VT.MethodsWe used structural and resting‐state functional magnetic resonance imaging before the pandemic to identify prospective brain markers for COVID‐related VT by correlating individuals' VT levels during the pandemic with the gray matter volume (GMV) and seed‐based resting‐state functional connectivity (RSFC) and examined how these brain markers linked CCT to VT in a sample of general young adults (N = 115/100).ResultsWhole‐brain GMV–behavior correlation analysis showed that VT was positively associated with GMV in the right dorsolateral prefrontal gyrus (DLPFC). Using the cluster derived from the GMV–behavior correlation analysis as the seed region, we further revealed that the RSFC between the right DLPFC and right precuneus was negatively associated with VT. Importantly, the right DLPFC volume and DLPFC‐precuneus RSFC mediated the effect of CCT on VT. These findings remained unaffected by factors such as family socioeconomic status, other stressful life events, and general mental health.ConclusionsOverall, our study presents structural and functional brain markers for VT and highlights these brain‐based markers as a potential neural mechanism linking CCT to COVID‐related VT, which has implications for treating and preventing the development of trauma‐related mental disorders.
A growth‐based screening method for entomopathogenic bacteria against Spodoptera frugiperda
Authors: Dai Hanyang , Zhang Zhichun , Niu Hongtao , Zhao Dongxiao , Qi Liangxuan , Sun Shuai , Wang Na , Guo Huifang 
Published: April 2024

AbstractEfficient screening methods are essential for rapidly identifying active microbial insecticidal resources, whereas current methods are mainly based on bioassay of alive pests, and it is time‐consuming. For developing new screening methods, we first collected field fall armyworm, Spodoptera frugiperda, and then we isolated 34 pathogenic bacteria isolates from dead larvae. After detecting six isolates of Serratia and Pediococcus which were the abundant bacteria species, we tested their proteinase and chitinase activities, along with their colony diameter on milk and chitin medium, and their biological activity against S. frugiperda. Based on a correlation analysis, we found a significant relationship between virulence and colony diameter in the six isolates. And then we verified the relationship by testing the other 28 isolates from fall armyworm. Therefore, we established a method for preliminary screening of potential pathogenic bacteria based on colony diameter of the isolate on milk medium, only isolates with colony diameter higher than 2.15 cm (cultured at 28°C for 72 h) were selected for further exploitation. Using the method, three bacteria isolates including JSJN2102 (Serratia nematodiphila), JSJN2103 (Providencia rettgeri) and JSJN2209 (Bacillus thuringiensis) were successfully obtained for their potential against S. frugiperda. The method will enable researchers to screen entomopathogenic bacteria more efficiently.
Emerging issues in fisheries science by fisheries scientists
Authors: Murray David S. , Campón‐Linares Victoria , O'Brien Carl M. , Thorpe Robert B. , Vieira Rui P. , Gilmour Fiona 
Published: April 2024

AbstractThe current epoch in fisheries science has been driven by continual advances in laboratory techniques and increasingly sophisticated approaches to analysing datasets. We now have the scientific knowledge and tools to proactively identify obstacles to the sustainable management of marine resources. However, in addition to technological advances, there are predicted global environmental changes, each with inherent implications for fisheries. The 2023 symposium of the Fisheries Society of the British Isles called for “open and constructive knowledge exchange between scientists, stakeholders, managers and policymakers” (https://fsbi.org.uk/symposium-2023/), a nexus of collaborative groups best placed to identify issues and solutions. Arguably, the Centre of Environment, Aquaculture and Fisheries Science (Cefas) and their Scientific Advice for Fisheries Management (SAFM) Team sit at the centre of such a network. SAFM regularly engages with managers and stakeholders, undertakes scientific research, provides fisheries advice to the UK government, and are leading experts within the International Council for the Exploration of the Sea (ICES). As such, this paper is an opinion piece, linked to individual authors specialisms, that aims to highlight emerging issues affecting fisheries and suggest where research efforts could be focused that contribute to sustainable fisheries.
Validation of GPT‐4 for clinical event classification: A comparative analysis with ICD codes and human reviewers
Authors: Wang Yichen , Huang Yuting , Nimma Induja R. , Pang Songhan , Pang Maoyin , Cui Tao , Kumbhari Vivek 
Published: April 2024

AbstractBackground and AimEffective clinical event classification is essential for clinical research and quality improvement. The validation of artificial intelligence (AI) models like Generative Pre‐trained Transformer 4 (GPT‐4) for this task and comparison with conventional methods remains unexplored.MethodsWe evaluated the performance of the GPT‐4 model for classifying gastrointestinal (GI) bleeding episodes from 200 medical discharge summaries and compared the results with human review and an International Classification of Diseases (ICD) code‐based system. The analysis included accuracy, sensitivity, and specificity evaluation, using ground truth determined by physician reviewers.ResultsGPT‐4 exhibited an accuracy of 94.4% in identifying GI bleeding occurrences, outperforming ICD codes (accuracy 63.5%, P < 0.001). GPT‐4's accuracy was either slightly lower or statistically similar to individual human reviewers (Reviewer 1: 98.5%, P < 0.001; Reviewer 2: 90.8%, P = 0.170). For location classification, GPT‐4 achieved accuracies of 81.7% and 83.5% for confirmed and probable GI bleeding locations, respectively, with figures that were either slightly lower or comparable with those of human reviewers. GPT‐4 was highly efficient, analyzing the dataset in 12.7 min at a cost of 21.2 USD, whereas human reviewers required 8–9 h each.ConclusionOur study indicates GPT‐4 offers a reliable, cost‐efficient, and faster alternative to current clinical event classification methods, outperforming the conventional ICD coding system and performing comparably to individual expert human reviewers. Its implementation could facilitate more accurate and granular clinical research and quality audits. Future research should explore scalability, prompt and model tuning, and ethical implications of high‐performance AI models in clinical data processing.
AtVQ25 promotes salicylic acid‐related leaf senescence by fine‐tuning the self‐repression of AtWRKY53
Authors: Tan Qi , Zhao Mingming , Gao Jingwei , Li Ke , Zhang Mengwei , Li Yunjia , Liu Zeting , Song Yujia , Lu Xiaoyue , Zhu Zhengge , Lin Rongcheng , Yin Pengcheng , Zhou Chunjiang , Wang Geng 
Published: April 2024

ABSTRACTMost mechanistic details of chronologically ordered regulation of leaf senescence are unknown. Regulatory networks centered on AtWRKY53 are crucial for orchestrating and integrating various senescence‐related signals. Notably, AtWRKY53 binds to its own promoter and represses transcription of AtWRKY53, but the biological significance and mechanism underlying this self‐repression remain unclear. In this study, we identified the VQ motif‐containing protein AtVQ25 as a cooperator of AtWRKY53. The expression level of AtVQ25 peaked at mature stage and was specifically repressed after the onset of leaf senescence. AtVQ25‐overexpressing plants and atvq25 mutants displayed precocious and delayed leaf senescence, respectively. Importantly, we identified AtWRKY53 as an interacting partner of AtVQ25. We determined that interaction between AtVQ25 and AtWRKY53 prevented AtWRKY53 from binding to W‐box elements on the AtWRKY53 promoter and thus counteracted the self‐repression of AtWRKY53. In addition, our RNA‐sequencing data revealed that the AtVQ25‐AtWRKY53 module is related to the salicylic acid (SA) pathway. Precocious leaf senescence and SA‐induced leaf senescence in AtVQ25‐overexpressing lines were inhibited by an SA pathway mutant, atsid2, and NahG transgenic plants; AtVQ25‐overexpressing/atwrky53 plants were also insensitive to SA‐induced leaf senescence. Collectively, we demonstrated that AtVQ25 directly attenuates the self‐repression of AtWRKY53 during the onset of leaf senescence, which is substantially helpful for understanding the timing of leaf senescence onset modulated by AtWRKY53.
Evaluation of nurse‐reported missed care in a post‐anesthesia care unit: A mixed‐methods study
Authors: Heng Laura Mun Tze , Rajasegeran Darshini Devi , Lim Siew Hoon 
Published: April 2024

AbstractBackgroundNurse‐reported missed care (NRMC) is considered as any significant delay or omission in provision of nursing care.Aim(i) Evaluate the frequency, types, and reasons for NRMC in the Post‐anesthesia Care Unit (PACU). (ii) Evaluate associations between nurse demographic and workload factors with NRMC. (iii) Explore nurses' perception of NRMC in the PACU.MethodsA cross‐sectional study was conducted in the PACU in a tertiary acute care hospital over 3 months. Full‐time PACU nurses were conveniently sampled to complete an anonymous survey after their daily shift over different shifts. It contained three sections: (i) nurse demographics; (ii) elements of NRMC; and (iii) reasons for NRMC. Qualitative interviews employed a semi‐structured guide to explore perceptions and experiences of NRMC. Descriptive, inferential statistics, and thematic analyses were applied.ResultsSixty‐six survey responses were collected. 48.5% of respondents indicated at least one NRMC activity. Activities more clinically sensitive were less missed. Eight nurses were interviewed. Four main themes were identified: (i) communication with patients; (ii) communication and teamwork with colleagues; (iii) dual role of documentation; and (iv) staffing inadequacy. Language barriers made communication challenging. Staff shortage exacerbates workload but effective teamwork and documentation facilitates nursing care.ConclusionCommunication and staffing concerns aggravate NRMC. Teamwork and personal contentment were satisfactory. Nurses' turnover intention may worsen staffing.Clinical RelevanceTimeliness and quality of nursing care is impacted by elements such as manpower, allocation of resources, work processes, and workplace environmental or interpersonal factors such as culture and language fit. Re‐evaluation of nursing resources and work processes may assist post‐anesthesia care unit nurses in fulfilling their role, decreasing the prevalence of nurse‐reported missed care.