bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of a fast automated photometric method for the analysis of sulfur dioxide in wines
Authors: Campo-Martínez Jairo-Francisco , Enseñat-Berea María-Luisa , Fernández-Paz Jaime , González-Castro María-José 
Published: March 2024

AbstractIn this work a simple and rapid automated analytical method for the determination of sulfur dioxide in wines by employing a sequential automatic analyser was validated. The methodology is based on the reaction of sulfur dioxide with 5,5′-dithiobis-(2-nitrobenzoic acid) in an alkaline medium followed by photometric detection. The linearity of the calibration curve was excellent (R2 = 1.000) and the LOQ (2.00 mg L−1) was well suited for the monitoring of regulatory limits. The accuracy and precision were evaluated with reference materials, providing highly successful results (RSD% < 3.8 for precision and R2 = 0.99 of correlation between the obtained and declared values). The method was applied to the analysis of commercial samples of wines ensuring compliance with legislation. The results found were compared to those obtained with the spectrophotometric method recommended for beers, implemented in a flow system, showing that there are no statistical differences between them (α ≤ 0.05). When compared with conventional methods, the proposed methodology showed to be fast, with minimum handling of the sample and small sample and reagents volume requirement, which together with a minimum maintenance, involves a considerable reduction in laboratory costs.
Non-invasive assessment of stimulation-specific changes in cerebral glucose metabolism with functional PET
Authors: Godbersen Godber Mathis , Falb Pia , Klug Sebastian , Silberbauer Leo R. , Reed Murray Bruce , Nics Lukas , Hacker Marcus , Lanzenberger Rupert , Hahn Andreas 
Published: March 2024

Abstract
Purpose
Functional positron emission tomography (fPET) with [18F]FDG allows quantification of stimulation-induced changes in glucose metabolism independent of neurovascular coupling. However, the gold standard for quantification requires invasive arterial blood sampling, limiting its widespread use. Here, we introduce a novel fPET method without the need for an input function.

Methods
We validated the approach using two datasets (DS). For DS1, 52 volunteers (23.2 ± 3.3 years, 24 females) performed Tetris® during a [18F]FDG fPET scan (bolus + constant infusion). For DS2, 18 participants (24.2 ± 4.3 years, 8 females) performed an eyes-open/finger tapping task (constant infusion). Task-specific changes in metabolism were assessed with the general linear model (GLM) and cerebral metabolic rate of glucose (CMRGlu) was quantified with the Patlak plot as reference. We then estimated simplified outcome parameters, including GLM beta values and percent signal change (%SC), and compared them, region and whole-brain-wise.

Results
We observed higher agreement with the reference for DS1 than DS2. Both DS resulted in strong correlations between regional task-specific beta estimates and CMRGlu (r = 0.763…0.912). %SC of beta values exhibited strong agreement with %SC of CMRGlu (r = 0.909…0.999). Average activation maps showed a high spatial similarity between CMRGlu and beta estimates (Dice = 0.870…0.979) as well as %SC (Dice = 0.932…0.997), respectively.

Conclusion
The non-invasive method reliably estimates task-specific changes in glucose metabolism without blood sampling. This streamlines fPET, albeit with the trade-off of being unable to quantify baseline metabolism. The simplification enhances its applicability in research and clinical settings.
Nursing and allied health workforce in Australian public rheumatology departments is inadequate: a cross-sectional observational study
Authors: Whittaker Glen A. , Hill Catherine L. , Bradbury Linda A , Millner Janet R. , Cliffe Harrison , Bonanno Daniel R. , Kazantzis Sia , Menz Hylton B. 
Published: March 2024

AbstractRheumatological conditions are complex and impact many facets of daily life. Management of people with rheumatological conditions can be optimised through multidisciplinary care. However, the current access to nursing and allied health professionals in Australia is unknown. A cross-sectional study of nursing and allied health professionals in Australian public rheumatology departments for adult and paediatric services was conducted. The heads of Australian public rheumatology departments were invited to report the health professionals working within their departments, referral pathways, and barriers to greater multidisciplinary care. A total of 27/39 (69.2%) of the hospitals responded. The most common health professionals within departments were nurses (n = 23; 85.2%) and physiotherapists (n = 10; 37.0%), followed by pharmacists (n = 5; 18.5%), psychologists (n = 4; 14.8%), and occupational therapists (n = 4; 14.8%). No podiatrists were employed within departments. Referral pathways were most common for physiotherapy (n = 20; 74.1%), followed by occupational therapy (n = 15; 55.5%), podiatry (n = 13; 48.1%), and psychology (n = 6; 22%). The mean full-time equivalent of nursing and allied health professionals per 100,000 population in Australia was 0.29. Funding was identified as the most common barrier. In Australia, publicly funded multidisciplinary care from nurses and allied health professionals in rheumatology departments is approximately 1.5 days per week on average. This level of multidisciplinary care is unlikely to meet the needs of rheumatology patients. Research is needed to determine the minimum staffing requirements of nursing and allied health professionals to provide optimal care.
The effect of balance exercises on central sensitization in patients with knee osteoarthritis
Authors: Tirasci Emre , Sarpel Tunay , Coskun Benlidayi Ilke , Deniz Volkan 
Published: March 2024

AbstractThe aim of this study was to evaluate the effectiveness of balance exercises on functional status, pain, balance, and central sensitization in patients with knee osteoarthritis (OA). Patients diagnosed with bilateral Kellgren–Lawrence grade ≥ 2 primary knee OA and associated central sensitization were included in the study. Patients were randomized into two groups. Both groups were provided with verbal and written information on knee OA. In addition, the intervention group received a supervised balance exercise program for 6 weeks, 3 days a week on alternating days. The outcome measures were the changes in the Central Sensitization Inventory (CSI), Visual Analog Scale (VAS) pain, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Berg Balance Scale, and Y Balance Test. Evaluations were performed at baseline, immediately after treatment (6th week) and at 12th week. The study included 40 patients, 20 patients in each group. At the end of the treatment period (6th week), the improvement in CSI score, WOMAC pain, WOMAC physical function, WOMAC total score, Y Balance Test scores, and VAS pain during activity was significantly greater in the intervention group than that in the control group (p < 0.001). Regarding the changes from baseline to the 12th week, the intervention group experienced greater improvement in most of the outcome measures. Yet, the change in WOMAC pain score, Berg Balance Scale score, and VAS pain at rest was similar between the study groups (p = 0.05, p = 0.257, and p = 0.385, respectively). A two-model multiple linear regression analysis revealed that the changes in VAS pain (during activity) after the treatment and at follow-up [(p = 0.004, adjusted R2: 0.346) and (p = 0.002, adjusted R2: 0.391), respectively], as well as changes in WOMAC pain from baseline to follow-up (p = 0.020, ΔR2 = 0.245) significantly affected central sensitization. However, changes in Y Balance Test and WOMAC total scores did not appear to have a significant impact on the improvement in central sensitization (p > 0.05). Balance exercises may provide improvement in central sensitization, functional status, and dynamic balance among patients with knee OA. The improvement in central sensitization depends mostly on the pain relief effect of balance exercises.
Multi-camera tracking of mechanically thrown objects for automated in-plant logistics by cognitive robots in Industry 4.0
Authors: Qadeer Nauman , Shah Jamal Hussain , Sharif Muhammad , Dahan Fadl , Khokhar Fahad Ahmed , Ghazal Rubina 
Published: March 2024

AbstractEmploying cognitive robots, capable of throwing and catching, is a strategy aimed at expediting the logistics process within Industry 4.0’s smart manufacturing plants, specifically for the transportation of small-sized manufacturing parts. Since the flight of mechanically thrown objects is inherently unpredictable, it is crucial for the catching robot to observe the initial trajectory with utmost precision and intelligently forecast the final catching position to ensure accurate real-time grasping. This study utilizes multi-camera tracking to monitor mechanically thrown objects. It involves the creation of a 3D simulation that facilitates controlled mechanical throwing of objects within the internal logistics environment of Industry 4.0. The developed simulation empowers users to define the attributes of the thrown object and capture its trajectory using a simulated pinhole camera, which can be positioned at any desired location and orientation within the in-plant logistics environment of flexible manufacturing systems. The simulation facilitated ample experimentation to be conducted for determining the optimal camera positions for accurately observing the 3D interception positions of a flying object based on its apparent size on the camera’s sensor plane. Subsequently, a variety of calibrated multi-camera setups were experimented while placing cameras at identified optimal positions. Based on the obtained results, the most effective multi-camera configuration setup is derived. Finally, a training dataset is prepared for 3000 simulated throwing experiments where the initial part of the trajectory consists of observed interception positions, through derived best multi-camera setup, and the final part consists of actual positions. The encoder–decoder Bi-LSTM deep neural network is proposed and trained on this dataset. The trained model outperformed the current state-of-the-art by accurately predicting the final 3D catching point, achieving a mean average error of 5 mm and a root-mean-square error of 7 mm in 200 real-world test experiments.
Total neoadjuvant therapy for locally advanced rectal cancer: a three-group propensity score matched study
Authors: Zhou Jiahao , Huang Jun , Zhou Zikai , Deng Xiangbing , Wu Qingbin , Wang Ziqiang 
Published: March 2024

Abstract
Purpose
Total neoadjuvant therapy (TNT) has emerged as a therapeutic approach for locally advanced rectal cancer (LARC). However, the optimal chemotherapy cycles within TNT remain uncertain. This study aimed to evaluate and compare the prognostic efficacy of varying cycles of chemotherapy during TNT for LARC.

Methods
Patients diagnosed with LARC (T3-4N0M0/T1-4N1-2M0), who underwent TNT or chemoradiotherapy followed by total mesorectal excision (TME) between 2015 and 2020, were retrospective included. Patients were categorized into three groups based on their neoadjuvant strategy: CRT (long-course chemoradiotherapy), STNT (long-course CRT with one to three cycles of chemotherapy), and LTNT (long-course CRT with four or more cycles of chemotherapy). Propensity score matching (PSM) based on gender, age, body mass index, tumor distance from the anal verge, clinical T stage, clinical N stage, and mesorectal fascia status was employed to reduce confounding bias. Primary endpoints were disease-free survival (DFS) and metastasis-free survival (MFS).

Results
The study comprised 372 patients, with 73 patients in each group after PSM. Compared with CRT, both STNT and LTNT demonstrated improved DFS (5-year rate: 59.7% vs. 77.8% vs. 76.5%, p = 0.027) and MFS (5-year rate: 65.1% vs. 81.3% vs. 81.4%, p = 0.030). There was no difference in DFS or MFS between STNT and LTNT. These favorable outcomes were consistent among subgroups defined by tumor distance from the anal verge ≥ 5 cm, clinical T3 stage, clinical N positive status, or involved mesorectal fascia.

Conclusion
Compared to CRT, both STNT and LTNT demonstrated improved DFS and MFS outcomes. Notably, survival outcomes were similar between STNT and LTNT, suggesting that chemotherapy cycles in TNT may not significantly impact survival.
The contradictive findings between ultrasound, hysteroscopy and cytokines in women with nonhormonal IUDs suffering from menorrhagia: a prospective study
Authors: Watad Hadel , Ifrach Udi , Stockheim David , Yulzari Vered , Meron Orly C. , Blank Miri , Sredni Benjamin , Weisz Boaz , Cohen Shlomo B. 
Published: March 2024

Abstract
Purpose
The objective of this study is to assess the correlation between bleeding irregularities and the accurate placement of the intrauterine device (IUD) device in the uterine cavity, determined through transvaginal ultrasonography and hysteroscopy. In addition, the study aims to examine the cytokine profile in the uterine cavity and serum of patients experiencing bleeding irregularities after the insertion of nonhormonal IUDs.

Methods
A prospective cohort study was conducted at a single tertiary medical center, wherein patients experiencing intermenstrual bleeding and spotting after the insertion of nonhormonal IUDs were enrolled. The study involved hysteroscopic and sonographic assessments of the uterine cavity and IUD placement, along with the analysis of blood and uterine cavity cytokine profiles.

Results
During the period between July 2019 and February 2020, a total of eight patients who experienced intermenstrual bleeding and spotting after the insertion of nonhormonal IUDs were enrolled the study. One case was excluded since a progestative device was detected by ultrasound. Out of the five cases that underwent a thorough ultrasonographic assessment, three cases (60%) showed an embedded IUD. However, these findings were excluded by the hysteroscopic evaluation.

Conclusion
The results suggest that ultrasonographic assessment may lead to an overdiagnosis of IUD mispositioning compared to hysteroscopy. In addition, both ultrasound and hysteroscopy have limitations in diagnosing the cause of bleeding in most cases. The role of local reactive inflammatory cytokines should be further studied.
Sex differences in modifiable risk factors for stroke incidence and recurrence: the UCC-SMART study
Authors: Rissanen Ina , Basten Maartje , Exalto Lieza G. , Peters Sanne A. E. , Visseren Frank L. J. , Geerlings Mirjam I. ,   For the UCC-SMART-Study Group, Cramer M. J. , van der Meer M. G. , Nathoe H. M. , de Borst G. J. , Bots M. L. , Geerlings M. I. , Emmelot-Vonk M. H. , de Jong P. A. , Lely A. T. , van der Kaaij N. P. , Kappelle L. J. , Ruigrok Y. M. , Verhaar M. C. , Dorresteijn J. A. N. , Visseren F. L. J. 
Published: March 2024

Abstract
Background and purpose
Risk factors for stroke differ between women and men in general populations. However, little is known about sex differences in secondary prevention. We investigated if sex interacted with modifiable risk factors for stroke in a large arterial disease cohort.

Methods
Within the prospective UCC-SMART study, 13,898 patients (35% women) with atherosclerotic disease or high-risk factor profile were followed up to 23 years for stroke incidence or recurrence. Hypertension, smoking, diabetes, overweight, dyslipidemia, high alcohol use, and physical inactivity were studied as risk factors. Association between these factors and ischemic and hemorrhagic stroke incidence or recurrence was studied in women and men using Cox proportional hazard models and Poisson regression models. Women-to-men relative hazard ratios (RHR) and rate differences (RD) were estimated for each risk factor. Left-truncated age was used as timescale.

Results
The age-adjusted stroke incidence rate was lower in women than men (3.9 vs 4.4 per 1000 person-years), as was the age-adjusted stroke recurrence rate (10.0 vs 11.7). Hypertension and smoking were associated with stroke risk in both sexes. HDL cholesterol was associated with lower stroke incidence in women but not in men (RHR 0.49; CI 0.27–0.88; and RD 1.39; CI − 1.31 to 4.10). Overweight was associated with a lower stroke recurrence in women but not in men (RHR 0.42; CI 0.23–0.80; and RD 9.05; CI 2.78–15.32).

Conclusions
In high-risk population, sex modifies the association of HDL cholesterol on stroke incidence, and the association of overweight on stroke recurrence. Our findings highlight the importance of sex-specific secondary prevention.
The role of identity priming on the (unconscious) bodily self-attribution
Authors: Ciorli Tommaso , Pia Lorenzo 
Published: March 2024

AbstractIt has been recently demonstrated that hand stimuli presented in a first-, with respect to a third-, person perspective were prioritized before awareness independently from their identity (i.e., self, or other). This pattern would represent an unconscious advantage for self-related bodily stimuli rooted in spatial perspective. To deeper investigate the role of identity, we employed a breaking-Continuous Flash Suppression paradigm in which a self- or other-hand presented in first- or third-person perspective was displayed after a conscious identity-related prime (i.e., self or other face). We replicated the unconscious advantage of the first-person perspective but, crucially, we reported that within the first-person perspective, other-hand stimuli preceded by other-face priming slowed down the conscious access with respect to the other conditions. These findings demonstrate that a top-down conscious identity context modulates the unconscious self-attribution of bodily stimuli. Within a predictive processing framework, we suggest that, by adding ambiguous information, the prime forces a prediction update that slows conscious access.
Molecularly defined sinonasal malignancies: an overview with focus on the current WHO classification and recently described provisional entities
Authors: Skálová Alena , Agaimy Abbas , Bradova Martina , Poorten Vincent Vander , Hanna Ehab , Guntinas-Lichius Orlando , Franchi Alessandro , Hellquist Henrik , Simpson Roderick H. W. , Lopéz Fernando , Nuyts Sandra , Chiesa-Estomba Carlos , Ng Sweet Ping , Homma Akihiro , Teng Yong , Leivo Ilmo , Ferlito Alfio 
Published: March 2024

AbstractClassification of tumors of the head and neck has evolved in recent decades including a widespread application of molecular testing in tumors of the sinonasal tract, salivary glands, and soft tissues with a predilection for the head and neck. The availability of new molecular techniques has allowed for the definition of multiple novel tumor types unique to head and neck sites. Moreover, an expanding spectrum of immunohistochemical markers specific to genetic alterations facilitates rapid identification of diagnostic molecular abnormalities. As such, it is currently possible for head and neck pathologists to benefit from a molecularly defined tumor classification while making diagnoses that are still based largely on histopathology and immunohistochemistry. This review covers the principal molecular alterations in sinonasal malignancies, such as alterations in DEK, AFF2, NUTM1, IDH1-2, and SWI/SNF genes in particular, that are important from a practical standpoint for diagnosis, prognosis, and prediction of response to treatment.
A clinico-anatomical dissection of the magnocellular and parvocellular pathways in a patient with the Riddoch syndrome
Authors: Beyh Ahmad , Rasche Samuel E. , Leff Alexander , ffytche Dominic , Zeki Semir 
Published: March 2024

Abstract
Key message
The Riddoch syndrome is thought to be caused by damage to the primary visual cortex (V1), usually following a vascular event. This study shows that damage to the anatomical input to V1, i.e., the optic radiations, can result in selective visual deficits that mimic the Riddoch syndrome. The results also highlight the differential susceptibility of the magnocellular and parvocellular visual systems to injury. Overall, this study offers new insights that will improve our understanding of the impact of brain injury and neurosurgery on the visual pathways.

Abstract
The Riddoch syndrome, characterised by the ability to perceive, consciously, moving visual stimuli but not static ones, has been associated with lesions of primary visual cortex (V1). We present here the case of patient YL who, after a tumour resection surgery that spared his V1, nevertheless showed symptoms of the Riddoch syndrome. Based on our testing, we postulated that the magnocellular (M) and parvocellular (P) inputs to his V1 may be differentially affected. In a first experiment, YL was presented with static and moving checkerboards in his blind field while undergoing multimodal magnetic resonance imaging (MRI), including structural, functional, and diffusion, acquired at 3 T. In a second experiment, we assessed YL’s neural responses to M and P visual stimuli using psychophysics and high-resolution fMRI acquired at 7 T. YL’s optic radiations were partially damaged but not severed. We found extensive activity in his visual cortex for moving, but not static, visual stimuli, while our psychophysical tests revealed that only low-spatial frequency moving checkerboards were perceived. High-resolution fMRI revealed strong responses in YL's V1 to M stimuli and very weak ones to P stimuli, indicating a functional P lesion affecting V1. In addition, YL frequently reported seeing moving stimuli and discriminating their direction of motion in the absence of visual stimulation, suggesting that he was experiencing visual hallucinations. Overall, this study highlights the possibility of a selective loss of P inputs to V1 resulting in the Riddoch syndrome and in hallucinations of visual motion.
Pancreatitis affects gut microbiota via metabolites and inflammatory cytokines: an exploratory two-step Mendelian randomisation study
Authors: Qiu Yi-Fan , Ye Jun , Xie Jin-Jin , Mao Xiao-Tong , Liu Yi-Long , Fang Qian , Qian Yang-Yang , Zou Wen-Bin , Cao Yu , Liao Zhuan 
Published: March 2024

AbstractPrevious studies have observed relationships between pancreatitis and gut microbiota; however, specific changes in gut microbiota abundance and underlying mechanisms in pancreatitis remain unknown. Metabolites are important for gut microbiota to fulfil their biological functions, and changes in the metabolic and immune environments are closely linked to changes in microbiota abundance. We aimed to clarify the mechanisms of gut–pancreas interactions and explore the possible role of metabolites and the immune system. To this end, we conducted two-sample Mendelian randomisation (MR) analysis to evaluate the casual links between four different types of pancreatitis and gut microbiota, metabolites, and inflammatory cytokines. A two-step MR analysis was conducted to further evaluate the probable mediating pathways involving metabolites and inflammatory cytokines in the causal relationship between pancreatitis and gut microbiota. In total, six potential mediators were identified in the causal relationship between pancreatitis and gut microbiota. Nineteen species of gut microbiota and seven inflammatory cytokines were genetically associated with the four types of pancreatitis. Metabolites involved in glucose and amino acid metabolisms were genetically associated with chronic pancreatitis, and those involved in lipid metabolism were genetically associated with acute pancreatitis. Our study identified alterations in the gut microbiota, metabolites, and inflammatory cytokines in pancreatitis at the genetic level and found six potential mediators of the pancreas–gut axis, which may provide insights into the precise diagnosis of pancreatitis and treatment interventions for gut microbiota to prevent the exacerbation of pancreatitis. Future studies could elucidate the mechanism underlying the association between pancreatitis and the gut microbiota.