bluuebunny/crossref_metadata_2025_split huggingface dataset:
Symbiotic combination of Akkermansia muciniphila and inosine alleviates alcohol-induced liver injury by modulating gut dysbiosis and immune responses
Authors: Wei Li , Pan Yizhi , Guo Yu , Zhu Yin , Jin Haoran , Gu Yingying , Li Chuanshuang , Wang Yaqin , Lin Jingjing , Chen Yongping , Ke Chunhai , Xu Lanman 
Published: March 2024

BackgroundAlcoholic liver disease (ALD) is exacerbated by disruptions in intestinal microecology and immune imbalances within the gut–liver axis. The present study assesses the therapeutic potential of combining Akkermansia muciniphila (A. muciniphila) with inosine in alleviating alcohol-induced liver injury.MethodsMale C57BL/6 mice, subjected to a Lieber-DeCarli diet with 5% alcohol for 4 weeks, served as the alcoholic liver injury model. Various analyzes, including quantitative reverse transcription polymerase chain reaction (qRT-PCR), ELISA, immunochemistry, 16S rRNA gene sequencing, and flow cytometry, were employed to evaluate liver injury parameters, intestinal barrier function, microbiota composition, and immune responses.ResultsCompared to the model group, the A. muciniphila and inosine groups exhibited significantly decreased alanine aminotransferase, aspartate aminotransferase, and lipopolysaccharide (LPS) levels, reduced hepatic fat deposition and neutrophil infiltration, alleviated oxidative stress and inflammation, and increased expression of intestinal tight junction proteins (Claudin-1, Occludin, and ZO-1). These effects were further pronounced in the A. muciniphila and inosine combination group compared to individual treatments. While alcohol feeding induced intestinal dysbiosis and gut barrier disruption, the combined treatment reduced the abundance of harmful bacteria (Oscillibacter, Escherichia/Shigella, and Alistipes) induced by alcohol consumption, promoting the growth of butyrate-producing bacteria (Akkermansia, Lactobacillus, and Clostridium IV). Flow cytometry revealed that alcohol consumption reduced T regulatory (Treg) populations while increasing those of T-helper (Th) 1 and Th17, which were restored by A. muciniphila combined with inosine treatment. Moreover, A. muciniphila and inosine combination increased the expression levels of intestinal CD39, CD73, and adenosine A2A receptor (A2AR) along with enhanced proportions of CD4+CD39+Treg and CD4+CD73+Treg cells in the liver and spleen. The A2AR antagonist KW6002, blocked the beneficial effects of the A. muciniphila and inosine combination on liver injury in ALD mice.ConclusionThis study reveals that the combination of A. muciniphila and inosine holds promise for ameliorating ALD by enhancing the gut ecosystem, improving intestinal barrier function, upregulating A2AR, CD73, and CD39 expression, modulating Treg cells functionality, and regulating the imbalance of Treg/Th17/Th1 cells, and these beneficial effects are partly A2AR-dependent.
Differential impact of unilateral stroke on the bihemispheric motor cortex representation of the jaw and tongue muscles in young and aged rats
Authors: Cullins Miranda J. , Connor Nadine P. 
Published: March 2024

IntroductionDysphagia commonly occurs after stroke, yet the mechanisms of post-stroke corticobulbar plasticity are not well understood. While cortical activity associated with swallowing actions is bihemispheric, prior research has suggested that plasticity of the intact cortex may drive recovery of swallowing after unilateral stroke. Age may be an important factor as it is an independent predictor of dysphagia after stroke and neuroplasticity may be reduced with age. Based on previous clinical studies, we hypothesized that cranial muscle activating volumes may be expanded in the intact hemisphere and would contribute to swallowing function. We also hypothesized that older age would be associated with limited map expansion and reduced function. As such, our goal was to determine the impact of stroke and age on corticobulbar plasticity by examining the jaw and tongue muscle activating volumes within the bilateral sensorimotor cortices.MethodsUsing the middle cerebral artery occlusion rat stroke model, intracortical microstimulation (ICMS) was used to map regions of sensorimotor cortex that activate tongue and jaw muscles in both hemispheres. Young adult (7 months) and aged (30 months) male F344 × BN rats underwent a stroke or sham-control surgery, followed by ICMS mapping 8 weeks later. Videofluoroscopy was used to assess oral-motor functions.ResultsIncreased activating volume of the sensorimotor cortex within the intact hemisphere was found only for jaw muscles, whereas significant stroke-related differences in tongue activating cortical volume were limited to the infarcted hemisphere. These stroke-related differences were correlated with infarct size, such that larger infarcts were associated with increased jaw representation in the intact hemisphere and decreased tongue representation in the infarcted hemisphere. We found that both age and stroke were independently associated with swallowing differences, weight loss, and increased corticomotor thresholds. Laterality of tongue and jaw representations in the sham-control group revealed variability between individuals and between muscles within individuals.ConclusionOur findings suggest the role of the intact and infarcted hemispheres in the recovery of oral motor function may differ between the tongue and jaw muscles, which may have important implications for rehabilitation, especially hemisphere-specific neuromodulatory approaches. This study addressed the natural course of recovery after stroke; future work should expand to focus on rehabilitation.
Hypercaloric low-carbohydrate high-fat diet protects against the development of nonalcoholic fatty liver disease in obese mice in contrast to isocaloric Western diet
Authors: Charlot Anouk , Bringolf Anthony , Mallard Joris , Charles Anne-Laure , Niederhoffer Nathalie , Duteil Delphine , Pagano Allan F. , Geny Bernard , Zoll Joffrey 
Published: March 2024

ObjectiveObesity and metabolic complications, such as type 2 diabetes and nonalcoholic fatty liver disease (NAFLD), are one of the greatest public health challenges of the 21st century. The major role of high sugar and carbohydrate consumption rather than caloric intake in obesity and NAFLD pathophysiology remains a subject of debate. A low-carbohydrate but high-fat diet (LCHFD) has shown promising results in obesity management, but its effects in preventing NAFLD need to be detailed. This study aims to compare the effects of a LCHFD with a high-fat high-sugar obesogenic Western diet (WD) on the progression of obesity, type 2 diabetes, and nonalcoholic fatty liver disease.MethodsMale C57BL/6J mice were initially fed a WD for 10 weeks. Subsequently, they were either switched to a LCHFD or maintained on the WD for an additional 6 weeks. Hepatic effects of the diet were explored by histological staining and RT-qPCR.ResultsAfter the initial 10 weeks WD feeding, LCHF diet demonstrated effectiveness in halting weight gain, maintaining a normal glucose tolerance and insulin levels, in comparison to the WD-fed mice, which developed obesity, glucose intolerance, increased insulin levels and induced NAFLD. In the liver, LCHFD mitigated the accumulation of hepatic triglycerides and the increase in Fasn relative gene expression compared to the WD mice. Beneficial effects of the LCHFD occurred despite a similar calorie intake compared to the WD mice.ConclusionOur results emphasize the negative impact of a high sugar/carbohydrate and lipid association for obesity progression and NAFLD development. LCHFD has shown beneficial effects for NAFLD management, notably improving weight management, and maintaining a normal glucose tolerance and liver health.
Biomarkers in retinopathy of prematurity: a systematic review and meta-analysis
Authors: Almutairi Mariam , Chechalk Katherine , Deane Emelia , Fox Rebecca , Janes Ava , Maguire-Henry Tidgh , McCabe Devin , O'Connor Cole , Quirk Joseph , Swan Evan , White Katherine , McCreery Kathryn , Isweisi Eman , Stewart Philip , Branagan Aoife , Roche Edna F. , Meehan Judith , Molloy Eleanor J. 
Published: March 2024

AimRetinopathy of prematurity is a significant global cause of childhood blindness. This study aims to identify serum biomarkers that are associated with the development of ROP.MethodsA systematic review and meta-analysis was conducted using PRISMA guidelines. Three databases were searched (Pubmed, Scopus and Web of Science) from 2003 to March 2023. Only studies investigating serum biomarker levels in preterm infants (&lt;37 weeks gestation) were included.ResultsMeta-analysis suggests that low serum IGF-1 levels have a strong association with the development of ROP [SMD (95% CI) of −.46 [−.63, −.30], p &lt; .001]. Meta-analysis suggests that higher serum glucose levels were associated with the development of ROP [SMD (95% CI) of 1.25 [.94, 1.55], p &lt; .001]. Meta-analysis suggests that thrombocytopenia is associated with the development of ROP [SMD (95% CI) of −.62 [−.86, −.37], p &lt; .001].ConclusionLow levels of serum IGF-1, high levels of serum glucose and thrombocytopenia all appear to have the strongest association with the development of ROP out of the 63 biomarkers investigated in this review. These associations highlight their potential use as diagnostic biomarkers in ROP, though further research is needed to establish the exact relationship between these biomarkers and disease pathogenesis.
Innovation in the realm of the unforeseen: a review of competence needed
Authors: Torgersen Glenn-Egil , Boe Ole , Magnussen Leif Inge , Olsen Dorothy Sutherland , Scordato Lisa 
Published: March 2024

IntroductionOur main research question in this article was: What are the competence structures for innovative processes? Both the nature of the unforeseen and innovation are related to something unknown, i.e., that competence needs to be developed to be able to handle situations and solutions that are not yet completely known. In our article, we address the question of how studies of innovation describe and use concepts of competence in various forms.MethodWe performed a systematic review of the relation between the unforeseen and innovation. In this systematic review we followed the Non-Interventional, Reproducible, and Open (NIRO) Systematic Reviews protocol. The identification of studies via databases and registers was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyzes (PRISMA) statement. The various types of competence found in the literature review were grouped in such a way that we could develop a structure to use as the basis for a new concept of competence needed in order to initiate and implement innovative processes. We refer to this overview of different competence types as designated competence structures for innovative processes. The searches resulted in the following number of abstracts, respectively Web of Science (2997), ERIC (454), and PsycInfo (550), meaning that a total of 3,768 abstracts were found to be relevant. The 3,768 abstracts were imported into the program Covidence for screening in the first search.ResultsAfter completing the evaluation process in accordance with the PRISMA checklist and flow diagram, 32 abstracts were found to be relevant for our research question as they were related to competence for the unforeseen and innovation.ConclusionFew of the studies we investigated specifically mention competence. Another finding is that the innovation literature describes the activities that should take place linked to what it refers to as competence. Thus, the innovation research field does not define what the competence is or what it consists of, at either individual or group level, but rather describes the activities that contribute to successful innovation in an organization with little emphasis on how this competence should be developed. Training perspectives are lacking when it comes to innovation literature perspectives on competence.
The relationship between health literacy and health-related quality of life in Chinese older adults: a cross-sectional study
Authors: Li Hui , Tao Simin , Sun Silu , Xiao Ying , Liu Yongbing 
Published: March 2024

BackgroundThis study aimed to examine the relationship between health literacy and health-related quality of life in older adults.MethodsA cross-sectional survey design was used. We used a self-administered questionnaire to assess sociodemographic factors of older adults, the Chinese Citizen Health Literacy Questionnaire (HLQC) and the 36-item Chinese version of the Short Form 36 (SF-36) to measure health literacy and quality of life, respectively, among older adults. Between September 2011 and June 2012, information was collected from 1,396 older adults in 44 nursing homes in four cities through face-to-face interviews.ResultsThe mean health literacy level of older adults in nursing homes was relatively low (71.74 ± 28.35). Health-related quality of life scores were moderate (104.77 ± 16.92). There were statistically significant differences in the effects of health literacy, education level, former occupation (professional), marital status (widowed) and race on health-related quality of life.ConclusionImproving health literacy is considered an important intervention to promote health-related quality of life in older adults in nursing homes.
Risk Prediction for Sudden Cardiac Death in the General Population: A Systematic Review and Meta-Analysis
Authors: Li Yue , Liu Zhengkun , Liu Tao , Li Ji , Mei Zihan , Fan Haojun , Cao Chunxia 
Published: March 2024

Objective: Identification of SCD risk is important in the general population from a public health perspective. The objective is to summarize and appraise the available prediction models for the risk of SCD among the general population.Methods: Data were obtained searching six electronic databases and reporting prediction models of SCD risk in the general population. Studies with duplicate cohorts and missing information were excluded from the meta-analysis.Results: Out of 8,407 studies identified, fifteen studies were included in the systematic review, while five studies were included in the meta-analysis. The Cox proportional hazards model was used in thirteen studies (96.67%). Study locations were limited to Europe and the United States. Our pooled meta-analyses included four predictors: diabetes mellitus (ES = 2.69, 95%CI: 1.93, 3.76), QRS duration (ES = 1.16, 95%CI: 1.06, 1.26), spatial QRS-T angle (ES = 1.46, 95%CI: 1.27, 1.69) and factional shortening (ES = 1.37, 95%CI: 1.15, 1.64).Conclusion: Risk prediction model may be useful as an adjunct for risk stratification strategies for SCD in the general population. Further studies among people except for white participants and more accessible factors are necessary to explore.
Botulinum Toxin and Progressive Pneumoperitoneum in Loss of Domain Ventral Hernias: A Systematic Review
Authors: Giuffrida Mario , Biolchini Federico , Capelli Patrizio , Banchini Filippo , Perrone Gennaro 
Published: March 2024

Introduction: Preoperative progressive pneumoperitoneum (PPP) and botulinum toxin A (BTX) have been used together in the preoperative preparation of patients with loss of domain hernias. This study aims to evaluate the efficacy and safety of the combined use of PPP and BTX.Methods: A systematic electronic search was performed according to the PRISMA criteria. A literature search of scientific articles was conducted up to December 2023. Articles were chosen based on the reference to BTX and PPP in loss of domain ventral hernias with a defect width greater than 10 cm before surgery. The GRADE methodology and the modified Newcastle-Ottawa scale were used to assess the quality of the studies.Results: The research yielded seven articles, with 217 patients analysed in total. BTX was performed 29.5 ± 1.7 days before surgery and PPP was inflated 14.8 ± 5.8 days before surgery. PPP complications were reported in 25.6% of patients, The average reduction of the volume of hernia (VH)/volume of the abdominal cavity (VAC) ratio was 7.6% (range 0.9%–15%). Only 40 patients (18.4%) required a PCS or TAR to repair the loss of domain hernias. The SSI and SSO rates were 17.5% and 26.2%, respectively. No differences in SSI and SSO rates were found between the different repair techniques. The recurrence rate was 5.9% (13/217). Recurrence was significantly higher in patients who underwent IPOM repair than other techniques (p &lt; 0.001).Conclusion: BTX and PPP may be useful tools for the management of loss of domain hernias presenting lower SSI and SSO. The combination of BTX and PPP reduces the use of more invasive repair techniques.
BIMBINGAN KONSELING TERHADAP KORBAN KEKERASAN DAN PELECEHAN SEKSUAL DI KABUPATEN TANGGERANG TAHUN 2022
Authors: Muhamad Laode , Kamaluddin Nashir Asep , Ummah Anicqotul 
Published: March 2024

Kegiatan Pengabdian ini bertemakan Pelecehan dan Kekerasan Seksual yang terjadi dimasyarakat pada akhir-akhir ini. Implikasi dari berdampak negatif terkhusus kepada korban. Generasi muda khususnya perempuan banyak mengalami kejadian ini dan sering ditutupi sebagai aib di masyarakat. Kegiatan ini bertujuan untuk memberikan pengalaman, pengetahuan dan komitmen kami untuk meminimalisir kejadian amoral seperti itu. Kami bermitra dengan Karang Taruna Benteng di Cisauk Tanggerang Banten bersama komunitas perempuan peduli pelecehan dan kekerasan seksual berharap bisa berkontribusi terhadap persoalan ini. Sehingga, tidak ada lagi predator amoral seksual yang bertentangan dengan nilai moral dan etika universal. Hasil yang didapatkan bahwa Sebagian besar terjadinya pelecehan dan kekerasan seksual terjadi karena kebutuhan seksual yang tidak terakomodir dengan baik. Kemudian adanya kesempatan, tingkat stress yang tinggi dan masalah ekonomi yang sedang dialami. Kebanyakan pelecehan seksual dilakukan oleh kaum laki-laki baik kepada ibu-ibu, gadis dan bahkan anak kecil sekalipun. Dengan adanya kegiatan ini diharapkan bisa bermanfaat buat masyarakat untuk mengetahui penyebab dan implikasi terhadap pelecehan seksual.
Historical Study Of Promotion Philosophy In Marketing Kajian Historis Filosofi Promosi Dalam Pemasaran
Authors: Cahyaningrum Anis Okta , Harsono Mugi 
Published: March 2024

Promosi dalam pemasaran sering dipandang sebagai hal yang krusial yang berhubungan dengan harapan dari produsen atau distributor terkait dengan kenaikan angka penjualan. Promosi berasal dari bahasa Latin “Promovere” yang berarti "bergerak maju" atau “mendorong maju” atau “memajukan suatu gagasan”. Dalam Kamus Besar Bahasa Indonesia (KBBI), definisi dari promosi adalah perkenalan dalam rangka memajukan usaha, dagang, dan sebagainya. Oleh karena itu juga dipperlukan adanya sebuah kajian historis filosofi dari promosi dalam pemasaran dari dimensi ontologi, epistimologi dan aksiologi kemudian dilanjutkan dengan pembahasan perkembangan promosi di era digital.
Pusat Literasi Gorontalo Dengan Pendekatan Arsitektur Monumentalism
Authors: Yusuf Mohamad , Haisah S , Tamrin Moh. Muhrim 
Published: March 2024

Literasi merupakan suatu kemampuan untuk memahami sebuah informasi baik dengan membaca, menulis maupun berkomunikasi. Literasi sudah menjadi gerakan yang lama dalam rangka meningkatkan minat masyarakat dalam membaca dan menulis. Gorontalo merupakan salah satu provinsi dengan tingkat membaca yang masih rendah yakni berada pada angka 30%. Dalam rangka meningkatkan minat baca masyarakat di Gorontalo maka perlu sebuah perencanaan pembangunan Pusat Literasi yang nantinya akan mengakomodasi segala aktivitas untuk meningkatkan minat baca masyarakat Gorontalo. Sehingga Literasi tidak hanya sebagai sebuah gerakan semata, tetapi mempunyai bangunan sendiri dalam rangka peningkatan minat baca. Pendekatan yang digunakan dalam perancangan ini adalah bangunan dengan konsep Monumentalis. Tujuannya dalah untuk memberikan tanda kepada masyarakat bahwa ini merupakan bangunan yang bersifat pendidikan
PEMANFAATAN BIOCHAR SPESIFIK LOKASI UNTUK BUDIDAYA SAYUR DI DESA LIMBUNG, KABUPATEN KUBU RAYA
Authors: Indrawati Urai Suci Yulies Vitri , Nusantara Rossie Wiedya , Sugito Hedi 
Published: March 2024

Desa Limbung, Kabupaten Kubu Raya terletak ± 5,12 km dari kota Pontianak dengan luas wilayah 800 km2. Sebagian besar masyarakatnya hidup sebagai petani sayur. Tanah lahan petani didominasi oleh tanah gambut yang mempunyai sifat kimia kurang menguntungkan untuk budidaya sayur. Kegiatan Pengabdian kepada Masyarakat (PkM) ini bertujuan untuk pemberdayaan petani dalam upaya pembuatan pupuk organik berbasis biochar limbah organik di sekitar lahan pertanian seperti sisa panen jagung, semak-semak, dan ranting pohon, sehingga dapat meningkatkan kesuburan tanah gambut, dan secara langsung dapat meningkatkan produksi pertanian di desa Limbung, kabupaten Kubu Raya. Kegiatan PkM berlangsung selama 4 bulan dimulai dari kegiatan persiapan, pelatihan pembuatan biochar, demplot biochar untuk tanaman hotikultur di lahan gambut dan pada akhir kegiatan, dilakukan evaluasi terhadap program- program yang telah dilakukan oleh tim abdimas. Evaluasi dilakukan untuk mengetahui hambatan/kesulitan yang dihadapi selama proses kegiatan, dan kemudian didiskusikan untuk diselesaikan. Sebelum kegiatan PkM ini dilakukan, peserta belum begitu memahami bagaimana pembuatan biochar dan kompos. Hasil kegiatan PkM ini, petani sayur mampu membuat biochar dari limbah hasil panen atau bahan organik disekitar lahan pertanian, sehingga membantu menyuburkan tanah gambut.
The Geochemical Potential for Metabolic Processes on the Sub-Neptune Exoplanet K2-18b
Authors: Glein Christopher R. 
Published: March 2024

Abstract
Quantifying disequilibria is important to understand whether an environment could be habitable. It has been proposed that the exoplanet K2-18b has a hydrogen-rich atmosphere and a water ocean, making it a “hycean world.” The James Webb Space Telescope recently made measurements of methane, CO2, and possibly dimethyl sulfide (DMS) in the atmosphere of this planet. The initial interpretation of these data is that they may support the occurrence of hycean conditions. Here I attempt to take a next step in exploring the prospects for habitability. I use constraints on the abundances of atmospheric gases to calculate how much chemical disequilibrium there could be, assuming that K2-18b is a hycean world. I find that the presence of oxidized carbon species coexisting with abundant H2 (1–1000 bars) at cool to warm (25°C–120°C) conditions creates a strong thermodynamic drive for methanogenesis. More than ∼75 kJ (mol C)−1 of free energy can be released from CO2 hydrogenation. Partially oxidized carbon compounds such as DMS (if present) also have the potential to provide metabolic energy, albeit in smaller quantities. Because of the thermodynamic instability of CO2 under hycean conditions, other reductive reactions of CO2 are likely to be favored, including the synthesis of amino acids. Glycine and alanine synthesis can be energy releasing or at least much less costly on K2–18b than in Earth’s ocean, even when NH3 is scarce but not totally absent. These first bioenergetic calculations for a proposed ocean-bearing exoplanet lay new groundwork for assessing exoplanetary habitability.