bluuebunny/crossref_metadata_2025_split huggingface dataset:
DERMATOGLYPHICS IN DARTER'S DISEASE
Authors: SHAMAI‐LUBOVITZ ORNA , TRATTNER AKIVA , KATZNELSON MARIASSA BAT‐MIRIAM , SANDBANK MIRIAM 
Published: May 2007

Abstract Background. Darier's disease is an acantholytic dyskeratotic genodermatosis with autosomal dominant inheritance. A predictive diagnostic marker for this disorder would be beneficial because of the relatively late onset and the large number of sporadic cases of the disease. The dermatoglyphic features of patients with Darier's disease were examined to determine whether they have a common pattern. Methods. Ink prints of fingers and palms obtained from 11 patients of both sexes with sporadic and familial Darier's disease were analyzed and compared with those of normal subjects. Results. No significant quantitative or qualitative differences were found between the dermatoglyphic features of our patients and those of a healthy population, except for punctate interruptions of the skin ridges that indicate pitting, a well‐known manifestation of Darier's disease. Conclusions. These results refute the conclusions of a previous publication claiming that there is a common characteristic dermatoglyphic feature in patients with this dermatosis.
CUTANEOUS INVOLVEMENT IN CHRONIC MYELOMONOCYTIC LEUKEMIA
Authors: O'CONNELL DAVID M. , PAGAN WAYNE A. , SKINNER STEVEN M. , PULITZER DONALD R. , DEVILLEZ RICHARD L. 
Published: May 2007

AbstractBackground. Chronic myelomonocytic leukemia has been associated with various nonspecific cutaneous manifestations. Rarely has the leukemia been reported to directly affect the skin. Methods. This case documents the progression of a patient who ultimately developed chronic myelomonocytic leukemia, by clinical examination, hematologic parameters, dermatopathology, and bone marrow pathology. Results. The skin showed nonspecific cutaneous involvement, progressing to specific leukemic lesions parallel with increasing systemic and hematologic involvement. Conclusions. Chronic myelomonocytic leukemia can manifest with lesions of leukemia cutis. The possibility of nonspecific cutaneous involvement in the preleukemic phase exists.
DIFFUSE INTRAEPIDERMAL DEPOSITION OF IMMUNOREACTANTS ON DIRECT IMMUNOFLUORESCENCE: A CLUE TO THE EARLY DIAGNOSIS OF EPIDERMAL NECROLYSIS
Authors: KING THEODORE , HELM THOMAS N. , VALENZUELA RAFAEL , BERGFELD WILMA F. 
Published: May 2007

Abstract Background. Toxic epidermal necrolysis is a distinctive disorder that is readily identified clinically and histologically in advanced cases. Early on, however, toxic epidermal necrolysis may be difficult to identify. Some consider fixed drug eruption a limited form of toxic epidermal necrolysis. Methods. Direct immunofluorescence was performed on biopsy material of erythematous skin lesions. Results. Diffuse deposition of immunoreactants in the midmalpighian layer was noted. This finding has not been encountered in other disorders studied in our immuno‐pathology laboratory. Conclusions. Diffuse immunoreactant deposition in the mid‐epidermis should suggest a diagnosis of epidermal necrolysis either from toxic epidermal necrolysis or fixed drug eruption. Additional cases will need to be assessed to document the usefulness of this pattern for prospective diagnosis.
LICHEN PLANUS SUBTROPICUS: DIRECT IMMUNOFLUORESCENCE FINDINGS AND THERAPEUTIC RESPONSE TO HYDROXYCHLOROQUINE
Authors: ALBERS SHARON E. , GLASS L. FRANK , FENSKE NEIL A. 
Published: May 2007

A 32‐year‐old black woman presented with the complained of a l‐year history of asymptomatic “dark areas” on her face and neck. New lesions developed throughout this time and, once present, slowly increased in size and persisted. She denied systemic symptoms, including arthralgias and myalgias. Her occupation as a real estate agent involved frequent outdoor work. The family history was noncontributory.On physical examination there were multiple hyperpig‐mented round‐to‐oval macules and papules measuring from 0.5 to 2.0 cm in diameter and located over the photoexposed lateral aspects of the face and neck (Figs. 1 and 2). New lesions were papules characterized by a subtle, raised “thread‐like” border (Fig. 1, arrow). Older lesions were mac‐ular, some with a slightly atrophic, hypopigmented center (Fig. 1, Flesh‐colored polygonal papules were present in the V‐shaped area on the anterior neck (Fig. 2). The remainder of the cutaneous examination, including the oral mucosa, was unremarkable.Histopathologic examination of a flesh‐colored papule viewed on low power revealed a bandlike lymphohistiocytic infiltrate that focally obscured the dermoepidermal junction. Numerous homogenous eosinophilic bodies (Civatte bodies, cytoid bodies, apoptotic cells) and scattered melanophages were identified. In addition, there was epidermal hyperplasia, overlying orthokeratosis, and V‐shaped hyper‐granulosis. The rete was jagged and possessed a slightly eosinophilic hue (Fig. 3).Hyperpigmented, oval macules had a more patchy lichenoid infiltrate, less epidermal hyperplasia, but possessed a greater number of melanophages in the papillary dermis than new lesions.Periodic acid‐Schiff (PAS) stained sections of either type of specimen were negative for basement membrane thickening and also negative for dermal mucin using the colloidal iron reagent.No deposits of immunoglobulin or complement were identified at the dermoepidermal junction by direct immunofluorescence microscopy, but numerous immunoglobulin‐coated cytoid bodies were present.Laboratory testing was significant for a negative antinu‐clear antibody (ANA) reaction and RPR. A complete blood cell count, results of serum chemistry, and the angiotensin converting enzyme level were within normal limits. Chest roentgenogram revealed no active cardiopulmonary disease.Based on the distinctive histopathology and the impressive, characteristic clinical presentation, the diagnosis of lichen planus subtropicus was made. Therapy with hydroxy‐chloroquine 200 mg per day, topical hydrocortisone valerate 0.2% cream b.i.d. to inflammatory lesions, 3% hydroquinone solution b.i.d. to hyperpigmented lesions, and photoprotection were initiated. Partial resolution of the lichenoid lesions has occurred, new lesions have ceased to appear, and the hyperpigmentation has slightly improved.
ULTRASTRUCTURAL STUDY OF HYALURONIC ACID BEFORE AND AFTER THE USE OF A PULSED ELECTROMAGNETIC FIELD, ELECTRORYDESIS, IN THE TREATMENT OF WRINKLES
Authors: GHERSETICH ILARIA , TEOFOLI PATRIZLA , BENCI MAURIZIO , LOTTI TORELLO 
Published: May 2007

Abstract Background. Treatment of wrinkles has become an increasing problem for dermatologists. Hyaluronic acid is a component of the family of glycosaminoglycans (GAGS, substances known for their property of retaining water), that significantly decreases with aging and in wrinkles. A new technique that uses a specific pulsed electromagnetic field, electrorydesis, has been introduced in the treatment of wrinkles associated with aging. The treatment is based on the reported in vitro effects of specific electromagnetic fields on fibroblast cultures (e.g., an increase in DNA synthesis and in the production of collagen and presumably also of GAGS). Methods. The in vivo effects of the electromagnetic field on aged skin (3 subjects aged 50, 56 and 60 years), with particular focus on the ultrastructural modifications and GAGS amount before and after the treatment, were evaluated by electron microscope. Results. The ultrastructural study (tissue stained with al‐cian blue) showed after treatment a significant increase (p < 0.005) of the electron‐dense granules (corresponding to hyaluronic acid), located in collagen elastic fibers, and in the soluble matrix. This presumably leads to subsequent edema that was clinically evident after the treatment. Conclusions. These data suggest that the increased levels of GAGS and the subsequent edema of the dermis could explain at least in part the clinical changes observed after electrorydesis treatment (e.g., swelling and “disappearance” of the wrinkle).
SWEET'S SYNDROME: CLINICOPATHOLOGIC STUDY OF ELEVEN CASES
Authors: HENG‐LEONG CHAN , LEE YU‐SHUNG , KUO TSENG‐TONG 
Published: May 2007

Abstract Background. The clinicopathologic manifestations of Sweet's syndrome associated with malignancy have been rarely studied in a large series. Methods. We describe the clinical features of Sweet's syndrome in 11 patients seen during the past 12 years. Histopathologic findings of these patients are discussed. The clinicopathologic manifestations of 249 cases of Sweet's syndrome reported in the literature were reviewed. Results. The clinicopathologic manifestations of Sweet's syndrome associated with hematologic disorders (HSS) were more severe and characterized by bullous pyoderma with more pronounced epidermal changes and ulceration, anemia, giant platelets and abnormal platelet counts. Approximately 40% of the Sweet's syndrome reported in the literature were associated with hematologic malignancy, and the other 7% of patients had solid tumors. Conclusions. Sweet's syndrome can be classified into three types: (1) association with hematologic disorders (HSS); (2) association with solid tumors (SSS); and (3) idiopathic or associated with various other disorders (ISS).
EOSINOPHILIC PUSTULAR FOLLICULAR REACTION: A PARADIGM OF IMMUNE DYSREGULATION
Authors: MAGRO CYNTHIA M.J. , CROWSON A. NEIL 
Published: May 2007

Abstract Background. We encountered 10 patients whose biopsies showed an eosinophilic pustular follicular reaction, a histomorphology alleged to be pathognomonic of eosinophilic folliculitis (EF). Only seven of these patients fell within the clinical spectrum of EF. Seven patients had conditions associated with immune dysfunction, including three patients with an atopic history. Potential antigenic stimuli could be elicited in six cases. Methods. Formalin‐fixed biopsy specimens from all 10 patients were available for examination. Hematoxylin and eosin‐, alcian blue‐periodic acid‐Schiff (PAS)‐ and PAS‐diastase‐stained sections cut from paraffin‐embedded tissue were examined by light microscopy. Immunoperoxidase preparations with antibody to IgE were performed on paraffin sections and the number of IgE‐decorated cells quantitated in each case. Four patients also had biopsy material submitted in Michel's medium, on which direct immunofluorescent studies were conducted. Results. IgE‐coated mononuclear cells were present in patients whose lesions would logically be expected to derive from dominant type I hypersensitivity mechanisms and absent or minimal in biopsies from those patients in whom the pathogenetic basis of lesions derived principally from cell‐mediated immunity. Conclusions. The eosinophilic pustular follicular reaction, while characteristic of EF, is not exclusive to that entity. It represents an expression of an excessive immediate or delayed‐type hypersensitivity reaction to various auto‐, epicutaneous, or ingested stimuli. A background of immune dysregulation may be contributory.
BURNING MOUTH SYNDROME
Authors: GRINSPAN DAVID , FERNÁNDEZ BLANCO GRACIELA , ANGEL ALLEVATO MIGUEL , STENGEL FERNANDO M. 
Published: May 2007

Abstract Background and Objectives. Burning mouth syndrome (BMS) is a frequent process that produces marked oral dysesthetic symptoms. There is controversy over its etiopathogenesis and diagnosis. Therapeutic results are unsatisfactory. The objectives of this study were: (1) to analyze a possible agreement on the definition of BMS; (2) to analyze its cause; (3) to propose a therapeutic scheme that has been shown to be highly effective in our experience and has not been previously reported. Methods. Five hundred patients with symptomatology of BMS were retrospectively evaluated with a study protocol, specially designed for this disease. Patients with local or general disease processes that could cause secondary asymptomatic stomatodynia were excluded from the study. Results. Most of the patients evaluated were women over 60 years of age with oral symptoms, including a sensation of heat and burning, and pain, lasting for months or years, and a history of multiple unsuccessful treatments. The patients showed depression associated with anxiety, with evidence of psychiatric disorders in the family. Based on these findings and eliminating symptomatic painful conditions of the mouth that may simulate this syndrome, we diagnosed a genuine or basic BMS of psychosomatic origin. Therapies used in the treatment of these neurotic conditions were not always useful. Tranylcypromine associated with anxiolytics and hypnotics in low doses plus the support of psychotherapy by the stomatologist were the most effective treatments. Conclusions. The BMS should be defined as a psychosomatic process causing oral dysesthesias for months or years.
DERMATOFIBROSARCOMA PROTUBERANS
Authors: KOH CHUAN K. , KO CHUNG B. , BURY HENRY P. R. , WYATT EDWARD H. 
Published: May 2007

Abstract Background. Dermatofibrosarcoma protuberans (dfsp) is an uncommon malignant tumor of the skin, the diagnosis of which can be difficult not only clinically but also histologically. The tumor has a low metastatic potential, but tends to recur locally if removal is incomplete. Methods. We reviewed the clinical and histologic features of 19 cases of dfsp, seen at the Department of Dermatology (14 cases) and Department of Surgery (5 cases) at the Hull Royal Infirmary between 1975 and 1992. Results. There were only 19 cases of dfsp diagnosed from a population of 500,000 over a period of 17 years. None of the cases were diagnosed clinically prior to histologic diagnosis. The highest incidence was in the 4th decade of age. The most frequent site was on the head and neck. None of the lesions metastasized but there were a total of eight incidents of local recurrence in five patients. Histologically all the cases showed presence of storiform‐pattern spindle‐shaped cells and new collagen formation. Conclusions. Dermatofibrosarcoma protuberans is a soft tissue tumor that is often not recognized clinically due to its rarity and variable appearance. Local recurrence is frequent. A wide surgical excision is the treatment of choice.
MULTIVARIATE ANALYSIS OF CUTANEOUS MARKERS OF AGING IN CHRONIC HEMODIALYZED PATIENTS
Authors: TERCEDOR JESÚS , LÓPEZ‐HERNÁNDEZ BEGOÑA , RÓDENAS JOSÉ M. , DELGADO‐RODRÍGUEZ MIGUEL , CEREZO SEBASTIAN , SERRANO‐ORTEGA SALVIO 
Published: May 2007

Abstract Background. Although hemodialysis has been associated with lesions of cutaneous aging, no controlled studies have been done in patients with chronic renal failure under periodic hemodialysis. Our purpose was to determine the prevalence of several clinical parameters of cutaneous aging and their relationship with hemodialysis. Methods. One hundred fourteen patients on chronic hemodialysis were investigated for the presence of several cutaneous aging markers in a cross‐sectional study, using multivariate analysis to minimize the confounding effect of age. Results. Skin cancer was diagnosed in 3 patients (2.6%), actinic keratoses in 12 (10.5%), senile lentigo in 22 (20%), senile purpura in 15 (13%), and Favre‐Racouchot disease in 6 (5%). There was no association with skin types or facial wrinkles with any other of the skin‐aging features studied. Multivariate analysis, controlling for age as a confounding variable, indicated that the degree of facial wrinkles and the decrease in stratum corneum hydration (capacitance) correlated significantly with the length of time on hemodialysis (P = 0.012 and P = 0.012, respectively). Favre‐Racouchot disease (Odds Ratio [OR] = 1.23, P = 0.055, 95% confidence interval [Cl] 0.99–1.52) and actinic keratoses (OR = 1.15, P = 0.076, Cl 0.98–1.34) became increasingly frequent with the duration of chronic hemodialysis. Conclusions. These data show a high prevalence of cutaneous aging lesions in patients on chronic hemodialysis. Acceleration of cutaneous aging is associated with time on hemodialysis.
TREATMENT OF PSORIASIS AT A DEAD SEA DERMATOLOGY CLINIC
Authors: ABELS DAVID J. , ROSE THEODORE , BEARMAN JACOB E. 
Published: May 2007

Abstract Background. The Dead Sea, with its unique optical, chemical, and atmospheric properties, provides an effective alternative treatment for psoriasis. Methods. The records of 1448 consecutive psoriasis patients treated at a Dead Sea psoriasis clinic were retrospectively evaluated concerning their treatment response and demographic characteristics. Results. Clearing of 80–100% was observed in 88% of the patients treated, including almost 58%, who had complete clearing. The demographic data studied that included gender, previous treatment at the Dead Sea, prior history of hospitalization for psoriasis, prior PUVA treatment, or a history of arthritis did not reveal any significant relationships, although overseas patients responded considerably better than Israelis. Conclusions. The overall response in a large cohort of psoriasis patients treated at the Dead Sea was excellent. Further prospective studies and basic investigations ate essential to understand the mechanism(s) involved and the relationships between other demographic data and the treatment response.
MIXED DIQUAT/PARAQUAT‐INDUCED BURNS
Authors: RONNEN MEIR , KLIN BARUCH , SUSTER SAUL 
Published: May 2007

Abstract Background. Ducatalon is a bipyridylium herbicide containing a mixture of diquat and paraquat, and is used in agriculture. Adverse reactions due to contact of this compound with the skin have rarely been described. Case Reports. Two men were seen for severe pain due to extensive chemical burns in the perineal and scrotal regions, caused by leaking of Ducatalon from defective equipment used for spraying the herbicide. The lesions responded well to treatment with topical silver sulfadiazine, combined with systemic antibiotics. The damaged skin healed without scarring within a few days. The lesions have not recurred after the faulty spraying apparatus was replaced. Conclusion. Direct contact of the skin with Ducatalon may lead to severe chemical burns. Proper precautions should be taken by the personnel handling this compound, with particular attention to the integrity of the equipment used for spraying the herbicide.
SUCCESSFUL TREATMENT OF CHROMOBLASTOMYCOSIS DUE TO FONSECAEA PEDROSOI BY THE COMBINATION OF ITRACONAZOLE AND CRYOTHERAPY
Authors: KULLAVANIJAYA PREYA , ROJANAVANICH VIBOON 
Published: May 2007

Abstract Background. Many methods and medications had been tried for the treatment of chromoblastomycosis with unsatisfactory results. Recently, there were several reports showing a good response of chromoblastomycosis to itraconazole, but it took as long as 18–30 months for lesions to heal. Methods. Itraconazole, 200 to 400 mg/day alone or in combination with monthly liquid nitrogen cryotherapy, was tried on 10 cases of chromoblastomycosis, caused by Fonsecaea pedrosoi in order to increase the potency of the drug and shorten the duration of treatment. Results. The 10 cases included five newly diagnosed and five recalcitrant cases. Two patients were cured by 200 mg/ day alone within 3 months. Seven patients required itraconazole, 400 mg/day, with combined cryotherapy to cure the lesions within 5 to 10 months. One case showed marked improvement but no cure. After the period of 1‐year follow‐up, only one case had a recurrent infection. Conclusions. Itraconazole was highly effective and may be useful in the treatment of chromoblastomycosis. A high dose is indicated in chronic fibrotic lesions in combination with liquid nitrogen cryotherapy, with higher efficacy and quicker healing than with medication alone.
MALIGNANT HEMANGIOENDOTHELIOMA
Authors: IHDA HAZUKI , TOKURA YOSHIKI , FUSHIMI MISAO , YOKOTE RYUICHI , HASHIZUME HIDEO , SHIRAHAMA SHIGEHO , IWATSUKI KEIJI , MURAKAMI KYOKO , TAKIGAWA MASAHIRO 
Published: May 2007

Abstract Background. The administration of interleukin‐2 (il‐2) has recently been reported to be favorable for treating malignant hemangioendothelioma (mhe). Methods. Two patients with mhe responded well to intra‐lesional injections of recombinant il‐2 (ril‐2) without major side effects. The purpose of this study was to characterize cells infiltrating the regressing tumor following ril‐2 treatment. Immunohistochemical studies were performed on biopsy specimens taken from ril‐2‐injected lesional skin. Results. It was shown that CD8+ lymphocytes and CD56+ natural killer (nk) cells infiltrated at the ril‐2‐injection sites, suggesting that these cells contributed to the tumor regression. In addition, MHE cells bore intercellular adhesion mole‐cule‐1 (icam‐1) whose expression was augmented by rn‐2 injections. Conclusions. These findings suggested, that ril‐2 not only induces lymphokine‐activated killer (lak) cells and nk cells, but also facilitates these cytotoxic cells to adhere to MHE cells by enhancing icam‐1 expression of tumor cells.
STEROID‐PULSE THERAPY IN PEMPHIGUS VULGARIS LONG TERM EOLLOW‐UP
Authors: CHRYSSOMALLIS FOTIS , DIMITRIADES ATHANASSIOS , CHAIDEMENOS GEORGE C. , PANAGIOTIDES DESPINA , KARAKATSANIS GEORGE 
Published: May 2007

Abstract Background. Patients with pemphigus vulgaris may occasionally present the highly active, widespread form of the disease, and/or maybe resistant to conventional oral steroid therapy, and/or manifest significant side effects from the prolonged use of high oral prednisone dosage. Our purpose was to evaluate the efficacy of steroid “pulse” therapy (PT) in these patients. Methods. Eight patients were given alternate‐day, one hour, infusions of 8, 9, or 10 mg/kg methylprednisolone Na succinate. Oral prednisone and a second immunosuppressive agent were simultaneously administered; these were rapidly decreased when control of the disease was achieved. Results. All patients initially responded well to therapy. The disease recurred in four patients after 3, 4, 9, and 16 months of remission, respectively. Three of these patients were treated again with pt and went into remission. None of the patients who received cyclophosphamide had a recurrence. One patient died of cardiac arrest, 12 days after pt. On a follow‐up of 59 ± 25 months since the last relapse, patients continue in remission. Conclusions. Pulse therapy is recommended as an adjunct to the total management plan of severely affected patients with pemphigus vulgaris. The addition of cyclophosphamide may prevent the disease from recurring. Alternate‐day small‐quantity bolus infusions over 16–20 days, may be equally effective as the administration of 15 mg/kg/daily for 3–5 days. The risk of cardiac arrest exists even with this, less aggressive form of pt therapy. A medical history of supraventricular arrhythmias may be considered a risk factor.
DIAGNOSIS OF CUTANEOUS TUBERCULOSIS BY POLYMERASE CHAIN REACTION USING A SPECIES‐SPECIEIC GENE
Authors: FAIZAL MICHEL , JIMENEZ GUIELERMO , BURGOS CESAR , DEL PORTILLO PATRICIA , ROMERO ROSA E. , PATARROYO MANUEL ELKIN 
Published: May 2007

Abstract Background. Diagnosis of tuberculosis (TB), especially cutaneous TBC, by conventional microbiologic methods is still a very laborious process and the results are usually inconclusive. Our purpose was to identify M. tuberculosis bacilli in uncultured clinical samples from skin lesions by means of the rapid, specific, and sensitive polymerase chain reaction (PCR). Methods. The PCR, using a set of species‐specific primers, was performed on biopsies and fluid secretions from lesions. Results. A positive amplification reaction was observed in three of the four samples studied. For one of the samples, the result was confirmed by a positive culture in Lowenstein‐Jensen medium and for the other two, by molecular hybridization and the clinical course of the patients after treatment. Samples obtained from a patient with panniculitis of Christian‐Weber and a normal skin biopsy were included as negative controls. Conclusions. We propose the PCR method as a tool for the diagnosis of cutaneous TBC. The presence of the M. tuberculosis in an erythema induratum of Bazin suggests a revision of the concept of this disease as a tuberculide reaction.