bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recursive K-index and iterative H-index
Authors: Knar Eldar 
Published: March 2024

Abstract
An aggregated recursive K-index (Kazakhstan Science Index) is proposed as the “Kazakhstan Science Citation Index” (Forum of Higher Education and Science-2023, 08/24/2023, Sayasat Nurbek, Ministry of Education and Science of the Republic of Kazakhstan).
In particular, it is proposed to switch from a pure strategy for assessing the quality and effectiveness of R&D using the H-index (Hirsch index) to a mixed strategy (in the context of publication activity as a combination of cooperative and noncooperative games) using the K-index on subnational and H-index on international or differentiated levels. In the context of a hybrid strategy of the scientist's payoff functions. This transition is correct and in demand for a number of national scientific systems with limited financial, material, infrastructural and linguistic (in terms of the English language) potential. Scientific systems with highly developed indigenous (autochthonous) characteristics are also needed insome scientific areas.
Some results on the counterproductivity of the Hirsch index for the Kazakh scientific system are presented. In particular, a significant increase in the H-index of Kazakh scientists was noted as the degree of scientific localization (national participation) decreased and as the degree of “foreign content” in science-intensive content increased within the framework of international joint collaboration. The abilityof the delocalization of local scientific content in joint publications to increase the H-index of Kazakh scientists was discovered. This effect is interpreted and confirmed by the positive and negative correlation coefficients between the Hirsch indices and the form and degree of participation (role functions) of Kazakh scientists in joint publications.
Comparative genomic studies of Tomtom and Nuaimi sheep breeds of Bahrain, and Asian and European sheep breeds revealed selection signatures
Authors: Tibbo Markos , Jawasreh Khaleel , Stella Alessandra , Al-Najar Muneer , Mahmoud Atia , Yusuf Ebrahim , Boettcher Paul , Looft Christian 
Published: March 2024

Abstract
The segments of the genome harboring genes subject to past selection because of their biological relevance can be identified due to their lower genetic divergence and distinctive regional linkage disequilibrium (LD) patterns. The origins of the sheep breeds known as Tomtom and Nuaimi in Bahrain are unknown, as are the special genetic variants that they carried throughout their evolution and presumably differ from ancient breeds native to Europe and Asian. We pinpointed signals of selection in sheep breeds by comparing the regional genomic (50k SNp chip) differences in LD variation between the Tomtom and Nuaimi sheep breeds with the Afshari, European Mouflon, Asian Mouflon, and Zel breeds. The autosomal genome's LD variation among breeds was compared using the VarLD approach. The NCBI assembly was used to assess the genomic regions bearing the top 0.01 and 0.1 percentiles of signals, determine the genes in those regions, and compare those regions with previously published selection signatures. The wild Mouflon (Asian and European) and Tomtom breeds were divided into three separate components by the PCA, whereas Nuaimi, Zel, and Afshari were grouped inside a single quartile and given special distinction because their individuals looked to be close to one another (genetically related). A total of 59 genes were found to be close to the selection signatures (94 selection signatures) detected on various ovine chromosomes, and many were crucial for reproductive and productive attributes that were influenced by selection as the Tomtom and Nuaimi sheep breeds evolved. According to the genome scan, the Tomtom sheep breed is genetically distant as it was isolated in a separate quartile, far from the Nuaimi, Zel, and Al-Afshari on the one hand, and Asian and European Mouflon on the other. The differences found between the studied breeds combinations may have resulted from special genomic selection signals (94) detected on different chromosomes. The results obtained for the Bahraini local sheep breeds are critical for the future genetic selection plan, as they will serve as a foundation for comparison with any future evolution.
Shift-Share Method in Assessing the Interrelation of Employment Dynamics in Cities and Regions
Authors: Zalmanov I. A. 
Published: March 2024

Purpose of the study. The aim of the study is to analyze the dynamics of employment in major cities of the Russian Federation, including megacities, in the context of rapid innovative development, complex demographic situation, and instability of external migration flows. The research focuses on identifying factors at various levels that affect employment, with an emphasis on the interconnections of cities and regions in the hierarchical “city-region” system. Materials and methods. The paper explores the shift-share method (SSM), which allows decomposing changes in employment with highlighting the influence of the overall dynamics of the regional labor market, industry characteristics, and competitive factors of cities. A multilevel analysis using this method aims to assess the structural-dynamic links of the hierarchically interconnected “city-region” system. The research uses municipal statistics data from 81 cities of the Russian Federation for the period from 2017 to 2021. Based on the concept of sectoral division of the economy, taking into account the functional features of the included industries, the structural-dynamic employment indexes in cities were analyzed across four economic sectors. Results. The application of the SSM method yielded results that allow for a detailed examination of employment dynamics in major cities. The analysis includes the influence of the overall dynamics of the regional labor market, industry characteristics, and competitive factors of cities. The research validates the effectiveness of the shift-share method for the preliminary analysis of employment dynamics in cities with the aim of specifying the significance of the impact on it by industrial and sectoral factors at regional and local levels and their prioritization for further analysis and the development of recommendations for urban economic management. Conclusion. The study highlights the importance of analyzing employment in the context of the urban economy, especially under conditions of rapid innovative development and demographic challenges. The SSM method appears to be an effective tool for preliminary examination of employment dynamics, identifying key factors, and developing management strategies aimed at improving the economic development of Russia’s major cities.
Intention to Use an Electronic Community Health Information System Among Health Extension Workers in Rural Northwest Ethiopia: Cross-Sectional Study Using the Unified Theory of Acceptance and Use of Technology 2 Model
Authors: Hailemariam Tesfahun , Atnafu Asmamaw , Gezie Lemma , Kaasbøll Jens , Klein Jorn , Tilahun Binyam 
Published: March 2024

Background
IT has brought remarkable change in bridging the digital gap in resource-constrained regions and advancing the health care system worldwide. Community-based information systems and mobile apps have been extensively developed and deployed to quantify and support health services delivered by community health workers. The success and failure of a digital health information system depends on whether and how it is used. Ethiopia is scaling up its electronic community health information system (eCHIS) to support the work of health extension workers (HEWs). For successful implementation, more evidence was required about the factors that may affect the willingness of HEWs to use the eCHIS.

Objective
This study aimed to assess HEWs’ intentions to use the eCHIS for health data management and service provision.

Methods
A cross-sectional study design was conducted among 456 HEWs in 6 pilot districts of the Central Gondar zone, Northwest Ethiopia. A Unified Theory of Acceptance and Use of Technology model was used to investigate HEWs’ intention to use the eCHIS. Data were cleaned, entered into Epi-data (version 4.02; EpiData Association), and exported to SPSS (version 26; IBM Corp) for analysis using the AMOS 23 Structural Equation Model. The statistical significance of dependent and independent variables in the model was reported using a 95% CI with a corresponding P value of <.05.

Results
A total of 456 HEWs participated in the study, with a response rate of 99%. The mean age of the study participants was 28 (SD 4.8) years. Our study revealed that about 179 (39.3%; 95% CI 34.7%-43.9%) participants intended to use the eCHIS for community health data generation, use, and service provision. Effort expectancy (β=0.256; P=.007), self-expectancy (β=0.096; P=.04), social influence (β=0.203; P=.02), and hedonic motivation (β=0.217; P=.03) were significantly associated with HEWs’ intention to use the eCHIS.

Conclusions
HEWs need to be computer literate and understand their role with the eCHIS. Ensuring that the system is easy and enjoyable for them to use is important for implementation and effective health data management.
Predictive and Prognostic Biomarkers in Patients With Mycosis Fungoides and Sézary Syndrome (BIO-MUSE): Protocol for a Translational Study
Authors: Belfrage Emma , Ek Sara , Johansson Åsa , Brauner Hanna , Sonesson Andreas , Drott Kristina 
Published: March 2024

Background
Cutaneous T-cell lymphoma (CTCL) is a rare group of lymphomas that primarily affects the skin. Mycosis fungoides (MF) is the most common form of CTCL and Sézary syndrome (SS) is more infrequent. Early stages (IA-IIA) have a favorable prognosis, while advanced stages (IIB-IVB) have a worse prognosis. Around 25% of patients with early stages of the disease will progress to advanced stages. Malignant skin-infiltrating T-cells in CTCL are accompanied by infiltrates of nonmalignant T-cells and other immune cells that produce cytokines that modulate the inflammation. Skin infection, often with Staphylococcus aureus, is frequent in advanced stages and can lead to sepsis and death. S. aureus has also been reported to contribute to the progression of the disease. Previous reports indicate a shift from Th1 to Th2 cytokine production and dysfunction of the skin barrier in CTCL. Treatment response is highly variable and often unpredictable, and there is a need for new predictive and prognostic biomarkers.

Objective
This prospective translational study aims to identify prognostic biomarkers in the blood and skin of patients with MF and SS.

Methods
The Predictive and Prognostic Biomarkers in Patients With MF and SS (BIO-MUSE) study aims to recruit 120 adult patients with MF or SS and a control group of 20 healthy volunteers. The treatments will be given according to clinical routine. The sampling of each patient will be performed every 3 months for 3 years. The blood samples will be analyzed for lactate dehydrogenase, immunoglobulin E, interleukins, thymus and activation-regulated chemokine, and lymphocyte subpopulations. The lymphoma microenvironment will be investigated through digital spatial profiling and single-cell RNA sequencing. Microbiological sampling and analysis of skin barrier function will be performed. The life quality parameters will be evaluated. The results will be evaluated by the stage of the disease.

Results
Patient inclusion started in 2021 and is still ongoing in 2023, with 18 patients and 20 healthy controls enrolled. The publication of selected translational findings before the publication of the main results of the trial is accepted.

Conclusions
This study aims to investigate blood and skin with a focus on immune cells and the microbiological environment to identify potential new prognostic biomarkers in MF and SS.

Trial Registration
ClinicalTrials.gov NCT04904146; https://www.clinicaltrials.gov/study/NCT04904146

International Registered Report Identifier (IRRID)
DERR1-10.2196/55723
EXPLORING THE THERAPEUTIC POTENTIAL OF AM114: A BORONIC CHALCONE DERIVATIVE INDUCE APOPTOSIS AND SUPPRESS PROINFLAMMATORY CYTOKINES AND CHEMOKINES IN INTERLEUKIN-1β STIMULATED HUMAN THP-1 DERIVED MACROPHAGES
Authors: SELVARAJAN CHITRA , GANESAN NALINI 
Published: March 2024

Objective: Chalcones and their derivatives display a wide range of pharmacological activities. This study examined the effects of AM114, a boronic-chalcone derivative, on human THP-1-derived macrophages with and without interleukin-1β (IL-1β) stimulation.
Methods: AM114 and Aspirin-treated THP-1-derived macrophages underwent activation with or without interleukin-1β. The IC50 concentrations of AM114 and Aspirin were determined through an MTT test. Apoptosis was measured using various techniques, including staining with acridine orange/Ethidium bromide, Hoechst 33342, and rhodamine 123 assays. Caspase-3 activity was measured using the spectrofluorimetric technique, while DNA fragmentation was assessed via agarose gel electrophoresis. Pro-inflammatory cytokines such as interleukin-6 (IL-6) and chemokines like interleukin-8 (IL-8) were measured using enzyme-linked immunosorbent assays.
Results: AM114 and Aspirin showed dose-dependent cytotoxic effects on THP-1 macrophages. Induction of apoptosis was detected in AM114-treated THP-1 macrophages activated with IL-1β compared to macrophages without IL-1β. The gradation of dye uptake, membrane blebbing, increased caspase-3 activity, and DNA fragmentation ensures the induction of apoptosis, which indicates the cell's morphological changes, biochemical processes, and mitochondrial activity. Treating AM114 in IL-1β-activated THP-1 macrophages significantly reduced pro-inflammatory cytokines (IL-6) and chemokines (IL-8), suggesting its anti-cytokine potential in inflammatory diseases.
Conclusion: The study results emphasize that AM114 could act as an anti-inflammatory agent by triggering apoptosis and reducing the release of cytokines and chemokines in inflammatory conditions. As a result, it may be used as a therapeutic option for inflammatory diseases.
UJI KUALITAS AIR SUNGAI DI HUTAN SUMATERA UTARA DITINJAU DARI KANDUNGAN BAKTERI
Authors: Sianipar Herna Febrianty 
Published: March 2024

Penelitian ini bertujuan untuk mengetahui kualitas air sungai di hutan Sumatera Utara ditinjau dari segi mikrobiologi perairan. Pengambilan sampel dilakukan di tiga titik pada lokasi yaitu sungai dekat hutan, sungai dekat pemukiman masyarakat, dan sungai dekat pertanian. Uji kandungan mikrobiologi dilaksanakan di Laboratorium Manajemen Pengelolaan Sumberdaya Perairan dengan menggunakan metode seri tabung 3-3-3. Hasil penelitian menunjukkan bahwa bakteri yang ditemukan pada sungai di hutan Sumatera Utara adalah bakteri coliform fecal dengan jumlah pada titik 1 (1360/100 ml), titik 2 (1580/100 ml), titik 3 (1210/100 ml). Kualitas air Sungai di hutan Sumatera Utara tidak memenuhi baku mutu air karena kandungan bakteri fecal coliform berada di atas baku mutu 1000/100 ml.
DEVELOPMENT OF PRESERVED-LEAVES LEARNING MEDIA ON PLANT MORPHOLOGY COURSE
Authors: Dahlia Dahlia , Afifah Nurul , Mubarrak Jismi , Karno Ria 
Published: March 2024

Learning media plays an important role in learning outcomes. This study aims to determine the feasibility of the developed of preserved- leaves media. This type of research is research and development with the Dick and Carey Models. The research started from the phase of needs analysis, development, design, implementation, validation and product testing. Data were collected using scala likert, processed using the percentage formula and analyzed descriptively. The test results on the product are very valid for the theory aspect (88.75%) and media aspect (83.67%), very practical (score 81.67% on the aspects of interest and ease to use), and very feasible (score 86, 25% for the small group test and 90.50% for the large group test). Thus, concluded that the preserved-leaves media is valid, practical and feasible to use for plant morphology course.
PENGARUH BUDAYA ORGANISASI DAN PENGEMBANGAN KARIR TERHADAP KINERJA TENAGA KEPENDIDIKAN INSTITUT SENI INDONESIA PADANG PANJANG
Authors: Lestari WInda , Yonita Riza , Nurofik Agus , Jasmalinda Jasmalinda , Trismiyanti Dessy 
Published: March 2024

Penelitian ini bertujuan untuk menganalisis Pengaruh Budaya Organisasi dan Pengembangan Karir Terhadap Kinerja Tenaga Kependidikan Di Institut Seni Indonesia Padang Panjang. Dalam penelitian ini, responden yang diteliti adalah tenaga kependidikan yang bekerja di Institut Seni Indonesia Padang Panjang, sebanyak 178 orang responden. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian kuantitatif asosiatif. Hasil dalam penelitian ini menunjukkan bahwa secara parsial variabel budaya organisasi berpengaruh positif dan signifikan terhadap kinerja, variabel pengembangan karir berpengaruh positif dan signifikan terhadap kinerja. budaya organisasi dan pengembangan karir secara simultan berpengaruh positif dan signifikan terhadap kinerja. Hasil nilai R2 adalah sebesar 0,594. Hal ini dapat diartikan bahwa budaya organisasi dan pengembangan karir berpengaruh terhadap kinerja dengan persentase sebesar 59,40%, sedangkan sisanya 40,60 % dipengaruhi oleh faktor lainnya yang tidak diteliti dalam penelitian ini. Berdasarkan analisis yang telah diujikan dapat disimpulkan bahwa variabel bebas budaya organisasi dan pengembangan karir memiliki pengaruh hubungan yang positif dan signifikan terhadap kinerja tenaga kependidikan di Institut Seni Indonesia Padang Panjang
Resignificación de la memoria en el pasado, presente y futuro: salud pública, salud mental y muerte
Authors: Bustamante Cataño Adriana Maria , Carmona Escobar John Alejandro , Hincapié Atehortúa Jhacesiz Mary 
Published: March 2024

En el año 2022, el Centro de Servicios de Salud del Sena Regional Antioquia en articulación con la Gobernación de Antioquia y en el marco del programa “Salud para el Alma”, realizó una intervención en campo, la cual contó con el apoyo de los programas de formación en salud pública y enfermería de los municipios de Andes, Ciudad Bolívar e Hispania. En dicho proceso se abordó, entre otros temas, la resignificación de la memoria: pasado, presente y futuro, como un acercamiento a las formas de vivenciar la muerte en el territorio desde la pérdida, el duelo, lo simbólico y su relación con la salud pública y la salud mental. Dicha intervención se adelantó en el municipio de Ciudad Bolívar Antioquia, corregimiento de San Gregorio.
En el presente artículo se da cuenta de los hallazgos que arrojó esta experiencia, con los elementos teóricos, conceptuales y reflexivos abordados, los cuales son desarrollados en cuatro momentos: en el primero de ellos se elabora una revisión conceptual de la salud pública, la salud mental y su relación con el concepto de la muerte. En el segundo momento se realiza un acercamiento al duelo y las manifestaciones individuales y colectivas asociadas a la muerte en el contexto de la salud pública. En el tercero se aborda la valoración de la vida y la muerte, el símbolo y representación en el territorio y en el cuarto se realiza un acercamiento al concepto de resiliencia como una herramienta para afrontar el pasado, el presente y el futuro.
Kosygina I.M., Makarov A.S., Potapchuk I.M. RHEOLOGICAL CHARACTERISTICS OF OIL-WATER-COAL DISPERSION SYSTEMS BASED ON DG COAL AND COMMA XTECH 5W-30 WASTE OIL
Authors: Kosygina I.M. , Makarov A.S. , Potapchuk I.M. 
Published: March 2024

Nowadays, the problem of the shortage of energy carriers, their economy, environmental friendliness, and the possibility of combining various clean or spent products of fuel materials for their fuller use and obtaining maximum energy is becoming more and more common. One of the effective solutions to this problem is the development of composite fuel, which consists of coal of different degrees of metamorphism, as well as liquid dispersion media of different chemical nature. The most famous liquid fuel is hydrocarbon fuel, which has several advantages over the burning of pure coal. But one of its disadvantages is its low caloric content due to its content of up to 40% of water by mass of coal. For rational burning of coal-based fuel, it is advisable to limit the water content to 10-15%. Therefore, it was proposed to replace part of the water environment with organic liquids - used oils, oil sludge, and safflower oils. For oil-hydrocarbon fuels, it is important to have certain characteristics - viscosity and stability for transportation, storage, and spraying of these systems. At the same time, oil-hydrocarbon emulsions are affected by various external factors, such as temperature, changing their characteristics. Therefore, in this work, the influence of temperature on the rheological properties of oil-hydrocarbon fuels was studied. During the analysis of the results of the conducted studies, it was established that there is a sharp decrease in the viscosity of the medium when the temperature increases from 10 °C to 20 °C. A further increase in temperature leads to a smaller decrease in the change in effective viscosity and at a temperature in the range from 60 °C to 70 °C, a slight decrease in the rate of change in rheological characteristics is observed. The obtained data indicate that transportation of OHCS by tanks or pipelines will not significantly affect the fluidity and stability of the systems.
Keywords: composite fuel; oil-hydrocarbon emulsion; long-flame gas coal; temperature dependence.
Symkanych О.І., Коkhan О.P., Glukh О.S., Krch K.L., Lytvyn О.V., Svatiuk N.І., Butsyak І.V. MONITORING OF RADIONUCLIDE MIGRATION IN THE BOTTOM SEDIMENTS OF THE TISA BILA RIVER' SOURCE
Authors: Symkanych O.I. , Kokhan O.P. , Glukh O.S. , Krch K.L. , Lytvyn O.V. , Svatiuk N.I. , Butsyak I.V. 
Published: March 2024

The regularities of distribution, migration, and accumulation of natural gamma-active nuclides 40K, uranium 238U (214Pb, 214Bi), and thorium 232Th (212Pb, 212Bi, 228Ac, 208Tl) series, as well as man-made 137Cs in the sediments of the tributary of the Tysa River (Bila Tysa), have been established. It is shown that the total content of the studied radionuclides in the bottom sediments along the entire length of the Tysa River differs slightly and is proportional to the level of its siltation. And this largely depends on many factors, in particular - the intensity of radionuclide exchange processes between soil and water, the water content in the soil, organic substances, and the morphological features of the river. Fluctuations of the total specific activity of natural gamma-active radionuclides (excluding 40K) in sediments within the range of 195.5-293.9 Bq/kg were established. The highest content of these isotopes was determined at the confluence of the White and Black Tisza. Mapping of the studied territories according to the content of 40K and 137Cs has show that the area of accumulation of gamma-active nuclides is concentrated in the lower part of the river (the point of confluence of the White and Black Tisza), and the probable causes of this phenomenon were substantiated. The analysis of the degree of connection between the content of radionuclides (238U and 232Th, 40K and 137Cs series) and the territorial factor showed that for the majority of GAN there is a zonal distribution - in the bottom sediments of the river source.
Keywords: radionuclides; gamma-active nuclides; radioecological monitoring; bottom deposits; migration; accumulation; Cs/K content; Tysa river.