bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability and validity of the medial standing overhead arm reach (SOAR) test as a measure of functional hip adduction motion
Authors: Grimes Jason , Wager Justin , DiZinno Casey , Fogarty Thomas , Hund Eric , Rooney Brendan , Roy Taylor , Goldfarb Jon , Bauer Paul 
Published: March 2024

Objective The Posterior Standing Overhead Arm Reach (SOAR) test has been previously reported as a reliable clinical measure of closed chain hip extension motion. The proposed Medial SOAR test expands on that testing approach to provide a similar measure of functional hip adduction motion. This was a preliminary intrarater and interrater reliability and validity study of the Medial SOAR test as a measure of functional hip adduction. Design Cross-sectional. Setting University motion analysis laboratory. Participants Fifty hips were assessed in 25 (22 female) asymptomatic participants (mean age = 23.4 years, SD = 0.8). Main measures Maximum hip adduction during the Medial SOAR test was measured with a standard goniometer independently by two examiners. The test was also performed using three-dimensional motion capture. The intrarater and interrater reliability of the goniometric measure was determined using intraclass correlation coefficients, and the relationship between measures obtained via goniometry and three-dimensional motion capture was assessed with Pearson correlations and Bland–Altman analysis. Results Intrarater reliability (ICC2,3) was 0.88 (95% CI = 0.80–0.92) for Examiner 1 and 0.87 (95% CI = 0.79–0.92) for Examiner 2. The standard error of measurement and minimal detectable change were less than 3.0°. Interrater reliability demonstrated an intraclass correlation coefficient = 0.62 (95% CI = 0.28–0.79). Pearson correlations were significant with low-to-moderate associations (r = 0.49, P < 0.001; r = 0.24, P = 0.045). Conclusions Similar to the previously reported Posterior SOAR test, the Medial SOAR test demonstrated acceptable intrarater and interrater reliability, along with low-to-moderate associations with three-dimensional motion capture. The Medial SOAR test has the potential to provide a reliable and accurate assessment of closed chain hip adduction.
Preparation and characterisation of heat‐resistant fluorinated co‐polyimides and their gas transport characteristics
Authors: Shi Yufei , Li Jinling , Wu Weilian , Ni Jing , Wei Bowen , Liu Chanjuan , Huang Xiaohua 
Published: March 2024

A series of fluorinated co-polyimide films based on the 6FDA-FTPPA/BAFL backbone were prepared from 4-(3-fluoro-4-(trifluoromethyl)phenyl)-2,6-bis(4-aminophenyl)pyridine (FTPPA),commercial 9,9-bis(4-aminophenyl)fluorene (BAFL), and 4,4’-(hexafluoroisopropylidene)diphthalic anhydride (6FDA), with varying ratios of FTPPA:BAFL units (3:1, 2:1, 1:1, 1:2, and 1:3). Co-polyimides not only exhibit high thermal stability ( Tg > 357°C), good optical properties (λcutoff > 327 nm) and hydrophobicity (contact angle >91.4°), but also favorable solubility properties in both high and low boiling organic solvents. The fractional free volume of the polymers was simulated using molecular mechanics and molecular dynamics and correlated with experimental gas separation data. The presence of bulky groups led to high FFVs (>17.8%) and the formation of large microcavities with diameters ranging from 5.48 to 5.72 Å, which efficiently increased gas permeability. In pure gas permeation experiments, the permeability coefficients of CO2 and He for the 6FDA-FTPPA/BAFL (3:1) film were 41.48 and 79.38 bar, respectively, which were superior to those of commercial Matrimid and Kapton in terms of gas permeability. In especial, the 6FDA-FTPPA/BAFL (1:2) and 6FDA-FTPPA/BAFL (1:3) in co-polyimide membranes exhibited the most attractive separation performance for O2/N2 gas pairs, approaching the 1991 Roberson upper limit.
Satisfaction and effectiveness of switching from intravenous to subcutaneous belimumab treatment in daily clinical practice
Authors: Frade-Sosa Beatriz , Salman-Monte Tarek Carlos , Narváez Javier , Peralta Irene , Sandoval Sebastian , Magallares Berta , Heredia Sergi , Sapena Nuria , Riveros-Frutos Anne , Olivé Alejandro , Corominas Hector , Cortés-Hernández Josefina , Gómez-Puerta José A 
Published: March 2024

Background In 2017, belimumab (BEL) was approved in subcutaneous (SQ) administration. The effectiveness after switching from intravenous (IV) to SQ and patient satisfaction in daily clinical practice has not been studied. During the pandemic, patient follow-up and treatment were significantly affected, and some patients need a change from IV to SQ. Our aim was to evaluate daily clinical practice satisfaction to SQ BEL therapy in patients previously treated IV BEL. We hypothesized that SQ BEL in SLE patients previously treated with IV BEL was similar in effectiveness and conferred higher satisfaction. Methods Observational, multicenter study, conducted in 7 reference centers in Catalonia. We included stable SLE patients (EULAR/ACR 2019) on treatment with SQ BEL and previous use of IV BEL (at least 3 months on IV BEL before switching). Since there are no well-validated tools for SQ BEL treatment satisfaction, we used RASQ-SQ, validated in patients with lymphoma who switched from IV Rituximab to SQ treatment, and modified for BEL treatment. Results Twenty-seven patients were included. The more prevalent clinical manifestations observed were related to the skin and joints and the patients had a mean baseline SLEDAI of 2.96 (SD 2.4) and SLICC score of 0.67 (SD 0.88). The median time from treatment with IV BEL before switching to SQ was 21 months (range). 84% of patients reported confidence in SQ BEL. 85.2% felt that treatment with SQ BEL was convenient or very convenient. 85% felt they had gained time with the change. 89% would recommend the SQ injection to other patients. Disease activity (mean SLEDAI) and remission rates remain stable after switching. No major new adverse effects were reported. Conclusions Overall satisfaction, satisfaction with via of administration, and satisfaction with the time taken to receive BEL were higher for SQ BEL treatment. A switching SQ strategy is a reasonable alternative for BEL patients.
Comparison of the SLE Risk Probability Index (SLERPI) scale against the European League Against Rheumatism/American College of Rheumatology (ACR/EULAR) and Systemic Lupus International Collaborating Clinics (SLICC) criteria
Authors: Castañeda-González Juan Pablo , Mogollón Hurtado Silvia Alejandra , Rojas-Villarraga Adriana , Guavita-Navarro Diana , Gallego-Cardona Laura , Arredondo Ana María , Cubides Héctor , Ibáñez Claudia , Escobar Alejandro , Cajamarca-Barón Jairo 
Published: March 2024

Introduction Timely diagnosis and proper recognition of Systemic Lupus Erythematosus (SLE) is essential to establish early management in inpatients and outpatients. There are different classification scales to identify SLE, which include various clinical and serological aspects. In 2021, the SLE Risk Probability Index (SLERPI) was published, which focuses predominantly on the clinical characteristics of patients with suspected SLE and uses a simple algorithm for early recognition of the disease. The aim of this study is to compare the European League Against Rheumatism/American College of Rheumatology (ACR/EULAR) classification criteria, the Systemic Lupus International Collaborating Clinics (SLICC) criteria, and the SLERPI criteria in a cohort of Colombian patients with SLE and to analyze the correlations observed between their absolute scores. Methods A registry of SLE patients from two referral hospitals in Bogotá, Colombia, was used. 2021 SLERPI, 2019 ACR/EULAR, and 2012 SLICC scores were calculated for each patient and the correlations found between the scales were analyzed. The sensitivities of each were compared, and frequency analyses were conducted among different clinical and laboratory variables. Results Between 2016 and 2019, 146 patients diagnosed with SLE were registered, including inpatients and outpatients. The median age was 36 years (interquartile range 26–51), and 82.2% were women. According to the SLERPI criteria, a high prevalence of antinuclear antibodies (92%), immunological disorders (71%), and arthritis (64%) were observed. The most used treatments were corticosteroids (87.6%) and chloroquine (67.8%). A Spearman evaluation analysis was performed, with a moderately strong correlation of 0.76 ( p = .000) between the SLERPI and ACR/EULAR scales and very strong correlation of 0.80 ( p = .000) between the SLERPI and SLICC. Patients classified with SLE according to the SLERPI scale exhibited a higher incidence of hematological compromise, along with elevated levels of serological markers such as anti-DNA antibodies. Additionally, this group more commonly received treatments involving corticosteroids and azathioprine, and displayed a higher prevalence of hypertension. Conclusion The SLERPI scale could be useful in the diagnosis of SLE, especially in early stages, given its good correlation with other classification scales and its good sensitivity.
Transforming HR Functions Through Shared Service: Insights from Indian Public Sector Power Major
Authors: Rai Alka , Maheshwari Sunil 
Published: March 2024

The case is about a prominent Indian public sector power company involved in the entire power generation value chain, encompassing fossil, hydro, nuclear and renewable energy sources. The organization is geographically divided into eight zones/regions: Central Region, DBF Region, Western Region-I, Western Region-II, Eastern Region-I, Eastern Region-II, Northern Region and Southern Region. In a conversation between Mr Anuj Kapoor, the Director of HR at this major power company, and Ms Abhika Choudhary, a researcher and academician, the discussion revolved around implementing human resources shared services (HRSS) within the organization. Initially undertaken to address manpower optimization challenges within HR functions, the complete transformation of HR functions through shared services gave Mr Kapoor valuable insights. Reflecting on this journey during the meeting with Ms Choudhary, he explored the entire spectrum from idea generation to implementation, including navigating resistance to change and post-implementation feedback. While Ms Choudhary diligently recorded the discussion to gain practical insights into the technological intervention in organizational HR functions, the flow of the conversation encountered a hurdle when delving into one specific post-implementation feedback from employees. This feedback pertained to the dichotomy of face or faceless HR in the era of HRSS within the company.
Radiographic Analysis of Valgus Ankle Deformity With or Without Medial Longitudinal Arch Collapse
Authors: Kim Jaeyoung , Palmar Joaquin , Demetracopoulos Constantine , Ellis Scott , Deland Jonathan 
Published: March 2024

Background: Establishing a surgical plan for ankle deformities necessitates a comprehensive understanding of the deforming forces involved, and the morphology of the ankle deformity plays an important role as well. Valgus tibiotalar tilt development has mostly been described in patients with a low medial longitudinal arch, as seen in progressive collapsing foot deformity (PCFD). However, some valgus ankles demonstrate no radiographic evidence of a collapsed medial arch. This study aims to investigate whether there are differences in the radiographic morphology of valgus ankle deformities between patients with and without a low medial longitudinal arch to explore if they have different etiologies. Methods: We retrospectively reviewed patients who underwent surgical treatment for asymmetric valgus ankle deformity at our institution between 2017 and 2021. Patients with a valgus tibiotalar tilt (TT) greater than 4 degrees and Meary angle greater than 30 degrees (mean: 38.9) were included in the PCFD group (n = 29). The non-PCFD group (n = 24) with TT greater than 4 degrees and Meary angle less than 4 degrees (mean: 0.3) was also established. In the weightbearing ankle anteroposterior view, the TT and medial distal tibial angle were measured. Additionally, to assess the mediolateral position of the talus, the talar center migration (TCM) and lateral talar dome–plafond distance (LTD-P) ratio in the coronal plane were measured. In weightbearing computed tomography (WBCT), the degree of axial plane talocalcaneal subluxation and the prevalence of sinus tarsi bony impingement were assessed. Intergroup comparison was conducted. Results: Both groups demonstrated a similar degree of TT, with a mean of 11.6 degrees in the PCFD group and 13.7 degrees in the non-PCFD group ( P = .2330). However, the PCFD group showed a significantly greater TCM and LTD-P ratio compared with those of the non-PCFD group ( P < .0001), indicating that PCFD patients have a more medially translated talus in ankle anteroposterior radiographs. WBCT showed that the PCFD group on average had 18 degrees greater axial plane talocalcaneal subluxation ( P < .0001) and 52% higher prevalence of sinus tarsi bony impingement ( P = .0002) compared with the non-PCFD group. Conclusion: This study suggests that valgus ankles may exhibit different radiographic morphologies depending on the status of the longitudinal arch. Valgus ankles in PCFD patients tend to have a more medially translated talus. This finding may suggest the presence of different deforming forces between the 2 groups and may indicate the need for different treatment strategies to address talar tilt. Level of Evidence: Level III, case-control.
Triglyceride-glucose Index as a Valuable Marker to Predict Severity of Coronary Artery Disease: A Retrospective Cohort Study
Authors: Geng Xu , Zhang Xi , Li XiaoWei , Zhong ChunTing , Hou Min 
Published: March 2024

Background and Aims The diagnostic standard of coronary artery disease (CAD) is coronary angiography (CAG). Since CAG is an invasive procedure underscores the need for identifying non-invasive, effective, and innovative biomarkers. Our study aimed to retrospectively analyze hematological markers for predicting the severity of CAD. Methods and Results Case data were collected from 195 CAD patients admitted to the hospital for CAG. According to Gensini score, patients were divided into mild, moderate, and severe CAD groups. Blood indexes and predictive efficacy of the triglyceride-glucose (TyG) index were retrospectively analyzed. Among 195 CAD patients, 81 had mild CAD, 60 had moderate CAD, and 54 had severe CAD. Sex, fast blood glucose (FBG), TyG index, and high-sensitivity C-reactive protein (hs-CRP) significantly differed among the three groups. The TyG index demonstrated higher values in patients with moderate (9.07[8.62-9.44]) and severe (8.98[8.46-9.45]) CAD compared to those with mild CAD (8.75[8.49-9.14]). The AUC of the TyG index was 0.615 (95% confidence interval (CI): 0.536-0.694, P =.004), with a cut-off value of 8.997, specificity of 0.704, and sensitivity of 0.535. Logistics analysis showed the risk of moderate and severe CAD with an odds ratio (OR) value of 2.595 (95% CI: 1.199-5.619, adjusted P = .016) following regrouping by the TyG index optimal cut-off value of 8.997. The TyG index combined with FBG and hs-CRP had an elevated AUC value, significantly higher than other combinations ( P  =  .011 and 0.02, respectively). Conclusions The severity of CAD is positively correlated with an increased TyG index value. A combination of TyG, FBG, and hs-CRP has demonstrated improved diagnostic efficiency, suggesting its potential as a novel indicator for predicting and diagnosing CAD progression.
Using simulation to improve pharmacy operators’ handling of cytotoxic spills
Authors: Garnier Alexandra , Bonnabry Pascal , Bouchoud Lucie 
Published: March 2024

Introduction International Society of Oncology Pharmacy Practitioners guidelines recommend having standard operating procedures (SOPs) and initial and yearly retraining programs on cytotoxic spill handling for pharmacy operators (POs). This study aimed to create a simulation-based training (SBT) program on this subject and evaluate its impact on POs’ real-life performance. Methods Randomly formed pairs of POs underwent a 2.5-hour training program, including two simulation exercises (a broken cytotoxic vial on the floor and a leaking cytotoxic bag) in a simulated pharmacy production unit. Each participant applied the cytotoxic spill handling SOPs. The PO and trainer-pharmacist did a debriefing after each exercise. Satisfaction was recorded on a 0-to-100% scale. A 20-item questionnaire assessed general knowledge about cytotoxic spill handling before and after the training. One month before and one month after the training, the POs underwent a real-life test when the trainer broke a fake cytotoxic vial in the cytotoxic storage area. Their performance in applying the SOPs was assessed on a 20-point checklist, and the time to handle the spill was recorded. Results Twelve POs participated. Mean satisfaction score was 98.9%. Mean knowledge score improved from 10.8/20 (SD = 2.0) before training to 14.5/20 (SD = 1.6) after training ( p < 0.05). Mean real-life SOP performance improved from 78.6% (SD = 7.4%) to 97.1% (SD = 5.2%) ( p < 0.05). Mean time to handle cytotoxic spills decreased from 17.3 minutes (SD = 3.6 minutes) to 11.9 minutes (SD = 1.5 minutes) ( p < 0.05). Conclusion POs improved their knowledge and real-life competencies for handling cytotoxic spills. This training will be included in POs’ initial and continuing training programs.
Numerical crashworthiness analysis of 2014 Aluminium-Silicon Carbide Particle (SiCp) foam filled Carbon Fiber-Reinforced Plastic (CFRP) tube under impact loading
Authors: Sahu Sonika , Kumar Pradeep , Dhimole Vivek Kumar , Kumar Narendra , Vusa Venkata Ravi , Ansari Mohd Zahid , Cho Chongdu 
Published: March 2024

Aluminium foam and Carbon Fiber Reinforced Plastic (CFRP) are widely used composite materials in automobile industries due to the benefits of lightweight and energy absorption capacity. Therefore, in this study, the numerical crashworthiness analysis of 2014 Aluminium-SiCp (2014AA-SiCp) foam filled in CFRP tube has been performed under impact loading. Quasi-static compression tests have been conducted on 2014AA-SiCp foam to extract the mechanical parameters required for numerical simulations. To understand the crushing behavior under the axial impact loading, 2014AA-SiCp foam-filled CFRP tube has been numerically modelled using ABAQUS® software. The parametric study was carried out to explore the effects of filler material, foam densities, and impact velocities on crushing behavior. It was found that load increases with the rise in foam density and impact velocity. Moreover, the deformation increases with the increase in impact velocity. Results showed that the load carrying capacity of foam filled CFRP tubes was significantly improved compared to that of empty CFRP tubes. The foam filled CFRP specimens exhibited peak load of 122 kN and an energy absorption capacity of 3012 J, showcasing an approximate improvement of 43% and 11% respectively, over the values obtained for empty CFRP tubes.
Euthyroid graves’ ophthalmopathy in a Chinese population: A cross-sectional follow-up study
Authors: Lai Kenneth KH , Ali Abdulla Aljufairi Fatema Mohamed , Sebastian Jake Uy , Chin Joyce KY , Choy Eric KH , Yiu Annika HL , Lee Alan CH , Ng CM , Yip Wilson WK , Young Alvin L , Yuen Hunter KL , Tham Clement CY , Pang Chi Pui , Chong Kelvin KL 
Published: March 2024

Objectives A subtype of patients with thyroid eye disease (TED) were found to be euthyroid without prior thyroid dysfunction or treatment, known as Euthyroid Graves’ Ophthalmopathy (EGO). We report the prevalence, clinical and serological phenotypes of EGO in a Chinese population. Methods A cross-sectional follow-up study. Ethnic Chinese TED patients were managed at the Thyroid Eye Clinic(TEC), Prince of Wales Hospital and TEC, the Chinese University of Hong Kong between September 2007 and July 2021. Results A total of 66 (5%) patients among the 1266 ethnic Han Chinese TED cohort were diagnosed as EGO, and 6 (9%)of them become dysthyroid over an average of 74-month follow-up. EGO patients were associated with a longer duration between onset of the symptoms to our first consultation ( P < 0.0001), a higher male-to-female ratio ( P = 0.0045) and a higher age of disease onset ( P = 0.0092). Family history of thyroid disease was more common in TED patients ( P = 0.0216) than in EGO patients. EGO patients were more likely to present unilaterally ( P < 0.0001), and they have a larger difference in MRD1 ( P < 0.0001), and extraocular motility ( P < 0.0001) between the 2 eyes when compared to the TED patients. Notably, the extraocular motility restriction of the worst eye was more affected in EGO patients ( P = 0.0113). The percentages of patients who received IVMP, ORT and emergency or elective surgeries(decompression or squint operation) between EGO and TED were similar. Conclusions Understanding the important clinical phenotypes of EGO may help the clinician to make the correct diagnosis. Further study to compare EGO and TED is warranted.
Uveal metastasis arising from thyroid neoplasms: A case study synthesis
Authors: Abdollahi Mirsaeed , Nateghian Hooman , Sobhi Navid , Abdshah Alireza , Jafarizadeh Ali 
Published: March 2024

Purpose We systematically reviewed the case report literature to identify cases of uveal metastases originating from thyroid cancer (TC), evaluate factors and indications in uveal metastases from TC, and provide clinical insights through recent case studies. Methods Web of Science, Medline, and Scopus databases were searched for case reports or series reporting uveal metastasis from a thyroid neoplasm. Articles published in any language from inception through November 2022 were searched and screened independently by two reviewers. The quality of the included studies was assessed using the JBI Critical Appraisal Checklist for Case Reports. Results A total of 1049 records were screened, resulting in the identification of 46 cases from 43 studies. The mean (SD) age at uveal metastases diagnosis was 58.44 (±17.99) years with the median (interquartile range) of 56.5 (29.75) (range, 20–83 years), with 34.8% of cases (16/46) cases reported in elderly patients (>64 years). The sample consisted of 56.5% (26/46) male patients. Uveal metastases were observed in the right eye in 16 cases, the left eye in 19 cases, and both eyes in 11 cases. Choroidal involvement was present in 84.8% of cases (39/46) cases. Papillary carcinoma was the most common thyroid cancer type (34.8%, 16/46), followed by follicular carcinoma (32.6%, 15/46), and medullary carcinoma (21.7%, 10/46). Conclusion Uveal metastases have been observed to appear in metastatic TC, and physicians should approach ocular symptoms cautiously in cases that accompany a neck mass or a history of previous TC.
Smoking as a Risk Factor for Very Late Recurrence in Surgically Resected Early-Stage Primary Hepatocellular Carcinoma
Authors: Cho Wei-Ru , Wang Chih-Chi , Tsai Mu-Jung , Lin Chih-Che , Yen Yi-Hao , Chen Chien Hung , Kuo Yuan-Hung , Yao Chih-Chien , Hung Chao-Hung , Huang Pao-Yuan , Liu An-Che , Tsai Ming-Chao 
Published: March 2024

Background: The risk of first recurrence of hepatocellular carcinoma (HCC) within years 5 to 10 after curative hepatectomy remains unknown. We aimed to assess the incidence and prognostic factors for very late recurrence among patients who achieved 5 years’ recurrence-free survival (RFS) after primary resection. Methods: We retrospectively analyzed 337 patients with early-stage HCC underwent primary tumor resection and achieved more than 5 years’ RFS. Results: A total of 77 patients (22.8%) developed very late recurrence. The cumulative very late recurrence rate increased from 6.9% and 11.7% to 16.6% at 6, 7, and 8 years, respectively. Patients stopped smoking had a higher rate of very late RFS. Conclusions: The high rates of very late recurrence in HCC indicate that patients warrant continued surveillance, even after 5 recurrence-free years. Moreover, smoking is a risk factor for very late HCC recurrence, and quitting smoking may reduce the risk of very late recurrence.