bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pattern of regional recurrence after selective neck dissection for clinically positive neck in mucosal squamous carcinoma
Authors: Altawil Mohammad , Stanisz Isabella , Van Den Berg Nadia H. , Sheahan Patrick 
Published: March 2024

AbstractBackgroundSelective neck dissection (SND) has traditionally been applied to clinically negative (cN0) necks in mucosal squamous cell carcinoma (SCC). We aimed to examine the oncological safety and patterns of regional recurrence (RR) of SND in clinically positive (cN+) necks.MethodsRetrospective review of prospective cohort of 206 patients with mucosal SCC undergoing neck dissection. RR was classified as occurring within previously dissected levels, within ipsilateral undissected levels, within unusual locations of ipsilateral neck, or contralateral neck.ResultsSeven of seventy‐seven (9.1%) cN+ patients undergoing SND developed isolated RR, versus 16.2% after MRND, and 8.7% after SND for cN0 disease. RR was rarely seen within undissected levels of the ipsilateral neck. RR and survival rates were not associated with ND extent (SND vs. MRND) among either cN+ or pN+ patients.ConclusionSND can be safely performed in most patients with cN+ SCC, who do not have gross sternocleidomastoid infiltration or level V metastases.
Sexual history of patients with human papillomavirus positive and negative oropharyngeal cancer: A systematic review and meta‐analysis
Authors: Durrant Frederick G. , Gutierrez Jorge A. , Nguyen Shaun A. , Nathan Cherie‐Ann O. , Newman Jason G. 
Published: March 2024

AbstractBackgroundIncreased sexual activity is associated with higher human papillomavirus (HPV) rates; however, there is a lack of analysis comparing the sexual history of patients with HPV positive and HPV negative oropharyngeal cancer (OPC).MethodsIn this meta‐analysis, PubMed, Scopus, and CINAHL were searched for articles that included patients with OPC and reported information regarding HPV status and either history of oral sex, number of sexual partners, or sexually transmitted infections (STI).ResultsA total of 11 studies were included with 3296 patients with OPC. Patients with HPV positive OPC were more likely than patients with HPV negative OPC to report a history of oral sex (92%, 95% CI: 87.0–97.0 vs. 74.5%, 95% CI: 50.6–98.4, p < 0.0001), higher mean number of sexual partners (18.4 partners, 95% CI: 1.5–35.4 vs. 7.2 partners, 95% CI: 1.0–13.4, p < 0.0001), and more frequent history of STI (23.7%, 95% CI: 18.4–29.0 vs. 8.8%, 95% CI: 4.7–12.8, p = 0.0001).ConclusionsCompared to patients with HPV negative OPC, our analysis shows a larger proportion of patients with HPV positive OPC had participated in oral sex, had a higher number of sexual partners, and had a higher proportion of STI history.
Incidence, survival, and mortality of cancer in children and young adolescents in Belgium and the Netherlands in 2004–2015: A comparative population‐based study
Authors: Peirelinck Hanne , Schulpen Maya , Hoogendijk Raoull , Van Damme An , Pieters Rob , Henau Kris , Van Damme Nancy , Karim‐Kos Henrike E. 
Published: March 2024

AbstractInternational comparisons of cancer surveillance measures may provide insight into inequalities in registration practices, etiological factors, and treatment strategies. This study aimed to compare incidence, survival, and mortality of cancer in children and young adolescents between Belgium and the Netherlands. All children (0–14 years) and young adolescents (15–17 years) diagnosed with cancer between 2004 and 2015 were selected from the population‐based cancer registries of Belgium (N = 4739) and the Netherlands (N = 7322). Differences in incidence and mortality were expressed as standardized rate ratios (SRR; BE/NL). Five‐year observed survival was calculated using the Kaplan–Meier method. During 2004–2015, the overall cancer incidence among children and young adolescents was similar in both countries. Incidence of neuroblastoma was significantly higher in Belgian children (2010–2015: SRR = 1.3, 95% CI 1.0–1.6). Five‐year survival of all malignant cancers was comparable in 2010–2015, exceeding 80% in both age groups. Remarkable differences in survival existed in children for malignant central nervous system (CNS) tumors in 2004–2009 (BE = 62%, NL = 45%), for acute myeloid leukemia (BE = 68%, NL = 78%) and rhabdomyosarcomas (BE = 60%, NL = 79%) in 2010–2015, and for neuroblastoma in both periods (2004–2009: BE = 76%, NL = 64%; 2010–2015: BE = 82%, NL = 64%). Overall cancer mortality in children decreased by approximately 3 percent‐points annually in both countries, but was slightly lower in Belgium in 2004–2009 (SRR = 0.9, 95% CI 0.7–1.0). Despite differences for specific cancer types, overall cancer incidence, survival, and mortality were comparable between Dutch and Belgian children and young adolescents in 2010–2015. Variability in screening, diagnosis, and registration practices probably explains the observed differences in incidence and survival of neuroblastoma and malignant CNS tumors.
Extrusion 3D‐printed tricalcium phosphate‐polycaprolactone biocomposites for quercetin‐KCl delivery in bone tissue engineering
Authors: Toulou Connor , Chaudhari Vishal Sharad , Bose Susmita 
Published: March 2024

AbstractCritical‐sized bone defects pose a significant challenge in advanced healthcare due to limited bone tissue regenerative capacity. The complex interplay of numerous overlapping variables hinders the development of multifunctional biocomposites. Phytochemicals show promise in promoting bone growth, but their dose‐dependent nature and physicochemical properties halt clinical use. To develop a comprehensive solution, a 3D‐printed (3DP) extrusion‐based tricalcium phosphate‐polycaprolactone (TCP‐PCL) scaffold is augmented with quercetin and potassium chloride (KCl). This composite material demonstrates a compressive strength of 30 MPa showing promising stability for low load‐bearing applications. Quercetin release from the scaffold follows a biphasic pattern that persists for up to 28 days, driven via diffusion‐mediated kinetics. The incorporation of KCl allows for tunable degradation rates of scaffolds and prevents the initial rapid release. Functionalization of scaffolds facilitates the attachment and proliferation of human fetal osteoblasts (hfOB), resulting in a 2.1‐fold increase in cell viability. Treated scaffolds exhibit a 3‐fold reduction in osteosarcoma (MG‐63) cell viability as compared to untreated substrates. Ruptured cell morphology and decreased mitochondrial membrane potential indicate the antitumorigenic potential. Scaffolds loaded with quercetin and quercetin‐KCl (Q‐KCl) demonstrate 76% and 89% reduction in bacterial colonies of Staphylococcus aureus, respectively. This study provides valuable insights as a promising strategy for bone tissue engineering (BTE) in orthopedic repair.
Mechanisms of revenue manipulation under ASC 606
Authors: Hubbard Benjamin 
Published: March 2024

AbstractThe implementation of ASC 606 significantly changed revenue recognition practices for many firms in the capital market by increasing the level of discretion required to record revenue amounts. I examine the impact of this increase in discretion on revenue manipulation around external targets. I find that firms near analyst revenue targets have increased levels of discretionary revenues under ASC 606 relative to their peers, indicating increased revenue manipulation. Further analysis reveals that these increased levels of discretionary revenues are concentrated in firms characterized as having increased opportunity or incentive to use ASC 606 opportunistically to manipulate revenues upwards. Specifically, firms with more complex revenue operations and firms in earlier life cycles are associated with increased discretionary revenues under ASC 606. I also provide preliminary evidence of revenue manipulation varying systematically with industry characteristics. This paper is one of the first to provide evidence of capital market consequences stemming from ASC 606, while also highlighting the impact of firm characteristics on the choice to manage revenues.
Hydrolysis mechanism of the cyclohexaborate anion: Unraveling the intricacies
Authors: Jia Lifan , Wang Yunxia , Song Lulu , Liu Ruirui , Li Longgang , Li Jisheng , Zhou Yongquan , Pan Jianmin , Zhu Fayan 
Published: March 2024

Abstract is a highly polymerized borate anion of three six‐membered rings. Limited research on the hydrolysis mechanism under neutral solution conditions exists. Calculations based on density functional theory show that undergoes five steps of hydrolysis to form H3BO3 and . At the same time, there are a small number of borate ions with different degrees of polymerization during the hydrolysis process, such as triborate, tetraborate, and pentaborate anions. The structure of the borate anion and the coordination environment of the bridging oxygen atoms control the hydrolysis process. Finally, this work explains that in existing experimental studies, the reason for the low content in solution environments with low total boron concentrations is that it depolymerizes into other types of borate ions and clarifies the borate species. The conversion relationship provides a basis for identifying the possibility of various borate ions existing in the solution. This work also provides a certain degree of theoretical support for the cause of the “dilution to salt” phenomenon.
β‐sheets mediate the conformational change and allosteric signal transmission between the AsLOV2 termini
Authors: Xiao Sian , Ibrahim Mayar Tarek , Verkhivker Gennady M. , Zoltowski Brian D. , Tao Peng 
Published: March 2024

AbstractAvena sativa phototropin 1 light‐oxygen‐voltage 2 domain (AsLOV2) is a model protein of Per‐Arnt‐Sim (PAS) superfamily, characterized by conformational changes in response to external environmental stimuli. This conformational change begins with the unfolding of the N‐terminal A'α helix in the dark state followed by the unfolding of the C‐terminal Jα helix. The light state is characterized by the unfolded termini and the subsequent modifications in hydrogen bond patterns. In this photoreceptor, β‐sheets are identified as crucial components for mediating allosteric signal transmission between the two termini. Through combined experimental and computational investigations, the Hβ and Iβ strands are recognized as the most critical and influential β‐sheets in AsLOV2's allosteric mechanism. To elucidate the role of these β‐sheets, we introduced 13 distinct mutations (F490L, N492A, L493A, F494L, H495L, L496F, Q497A, R500A, F509L, Q513A, L514A, D515V, and T517V) and conducted comprehensive molecular dynamics simulations. In‐depth hydrogen bond analyses emphasized the role of two hydrogen bonds, Asn482‐Leu453 and Gln479‐Val520, in the observed distinct behaviors of L493A, L496F, Q497A, and D515V mutants. This illustrates the role of β‐sheets in the transmission of the allosteric signal upon the photoactivation of the light state.
Integrating Full Bayesian Inference and Student's t‐Distribution Method for Enhanced Outlier Handling in Caffeine Population Pharmacokinetics: Assessing Drug–Drug Interactions with Enasidenib in Relapsed or Refractory AML and MDS Patients
Authors: Cheng Yiming , Du Shengnan , Hu Hongxiang , Wang Xiaomin , Carayannopoulos Leon , Li Yan 
Published: March 2024

AbstractAs the first‐in‐class, selective, and potent inhibitor of the isocitrate dehydrogenase‐2 (IDH2) mutant protein, enasidenib was approved by the US Food and Drug Administration (FDA) in 2017 for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with an IDH2 mutation. Known for its interactions with various cytochrome P450 (CYP) enzymes and transporters in vitro, a clinical pharmacokinetics (PK) trial was initiated to assess the impact of multiple doses of enasidenib on the single‐dose PK of sensitive probe substrates of several cytochrome P450 enzymes and transporters. In this study, a population pharmacokinetic analysis approach was employed to address challenges posed by high, nonzero baseline caffeine concentrations. Moreover, we integrated full Bayesian inference into this approach innovatively for a more detailed understanding of parameter uncertainty and greater modeling flexibility, alongside Student's t‐distribution for robust error modeling in handling the abnormal outlier caffeine concentration data observed in this trial. Our analyses demonstrated that multiple doses of enasidenib altered caffeine clearance to a clinically meaningful extent, as evidenced by an approximate 8‐fold decrease. This finding led to a specific recommendation in the package insert to avoid the concurrent use of certain CYP1A2 substrates with enasidenib, unless directed otherwise in the prescribing information. Furthermore, this research underlines the technical benefits of integrating full Bayesian inference and incorporating Student's t‐distribution for residual error modeling in the PK field.
Photocatalytic bio‐inspired PDA‐RGO/g‐C3N4 nanocomposite incorporated PES membrane for removal of environmental antibiotic pollutants
Authors: Govardhanan B. , GokulaKrishnan S.A. , Arthanareeswaran G. , Ashok M. , Chen Yong‐Song , Taweepreda W. 
Published: March 2024

AbstractBACKGROUNDMembrane technology makes it more suitable for the treatment of environmental polluted organic wastewater. Membrane fouling is one of the major concerns in commercial membranes. To overcome this issue, photocatalytic nanomaterials are embedded into the membrane to enhance its surface nature and reusability. In this investigation, polydopamine functionalized graphene oxide (PDA‐RGO), graphite carbon nitride (g‐C3N4) and PDA‐RGO/g‐C3N4 nanomaterials were incorporated within polyethersulfone membrane fabricated via a phase inversion technique. These as‐prepared membranes’ functional groups and surface morphologies were investigated by Fourier transform infrared (FTIR) spectroscopy, atomic force microscopy (AFM) and field emission electron microscopy (FESEM). These as‐prepared membranes were investigated for photocatalytic activity under visible‐light‐driven photodegradation by environmental pollutants such as Rhodamine B (RhB) and Norfloxacin (NOR).RESULTSCompared with pristine PES membrane, the PDA‐RGO/g‐C3N4‐PES nanocomposite membrane showed higher photocatalytic activity for Rhodamine B 94.6% and Norfloxacin 96.8%, also reached greater water flux 189 L m−2 h−1. Therefore, the bio‐inspired nanocomposite‐modified PDA‐RGO/g‐C3N4 photocatalytic membrane could have huge potential in processing environmentally polluted water.CONCLUSIONSPDA‐RGO/g‐C3N4‐PES nanocomposite membrane improved the membrane hydrophilicity, water flow, anti‐fouling performance, rejection studies and photocatalytic degradation than the pristine membrane. The synergistic result of PDA‐RGO and g‐C3N4 exhibits better photodegradation efficiency of the membrane towards environmental pollutants. © 2024 Society of Chemical Industry (SCI).
Insights into the G‐quadruplex DNA interaction landscape: Comparative analysis of anionic Zn(II) and Co(II) phthalocyanine‐tetrasulfonate complexes
Authors: Bağda Efkan 
Published: March 2024

AbstractG‐quadruplexes play a pivotal role in regulating various cellular processes, including gene expression and replication, making them essential structures in understanding, and manipulating cellular functions. The development of G‐quadruplex ligands holds significant promise in therapeutic and research applications, offering targeted tools to modulate G‐quadruplex structures and potentially influence critical biological pathways. An exciting frontier in G‐quadruplex research lies in the exploration of anionic ligands, and their profound impact on stabilizing and modulating G‐quadruplex DNA. In this study, the interaction of two anionic phthalocyanine compounds (Zinc (II) phthalocyanine 3,4′,4″,4‴‐tetrasulfonic acid, tetrasodium salt, ZnAPC; cobalt (II) phthalocyanine 3,4′,4″,4‴‐tetrasulfonic acid, tetrasodium salt, CoAPC) and three separate G‐quadruplex‐forming DNA sequences was investigated. Interactions were carried out by DNA polymerase stop studies along with spectroscopic studies. According to the results of experimental data, it was determined that ZnAPC actively interacts with the G‐quadruplex DNA structures. On the other hand, it was thought that the interaction with CoAPC was less and even occurred in simple electrostatic interactions. KD constants and Bmax constants for the interaction with ZnAPC were calculated. The KD constants for ZnAPC were found to be (1.16 ± 0.07) × 10−5, (9.75 ± .24) × 10−6 and (1.00 ± 0.36) × 10−4 M for AS1411, Vegf, and Tel21, respectively. Accordingly, it was concluded that ZnAPC interacts with G‐quadruplex DNA ligands effectively.
The relationship between December haze pollution in the Sichuan Basin and preceding climate factors
Authors: Luo Yu , Zhao Pengguo , Xu Luyang , Chen Chao , Wang Shunjiu , Liu Jia 
Published: March 2024

AbstractHaze pollution (HP) is one of the most serious disasters in the Sichuan Basin (SCB), adversely affecting human health, transportation, tourism and agriculture. HP in December is severe and differs from the haze days in January and February in terms of their temporal variations. To improve the understanding of December haze days in the SCB (DHDSCB), this study not only shows the atmospheric circulations and local meteorological circumstances related with the haze variation, but also analyses its relationship with the prior atmospheric apparent heat source over the Tibetan Plateau (TP) and the sea surface temperature (SST). The key circulation system associated with the interannual variation of the DHDSCB is that the SCB is controlled by the positive geopotential height anomalies and anomalous anticyclonic circulations with weak southwestward water vapour transport. Moreover, unfavourable local meteorological circumstances limit the vertical (horizontal) dispersion of pollutants. In addition, the DHDSCB during 1981–2022 is also found to have significant relationships with two preceding climate factors, which are the atmospheric apparent heat source (Q1) over the western TP in preceding November and the SST difference between the western Maritime Continent and western Australia in preceding autumn. The enhancement of Q1 over the western TP in preceding November is closely related to the midlatitude North Atlantic–southern Mediterranean Middle East–Arabian Sea–TP and its downstream region teleconnection pattern. Consequently, the anticyclonic circulation prevails over the SCB, and SCB is with less precipitation and more haze days in December. The western Maritime Continent and western Australia SST pattern in preceding Autumn is correlated with the Bay of Bengal–eastern TP and its downstream–Japan–Bering Sea teleconnection pattern, providing unfavourable moisture condition for the precipitation over the SCB and leading to the onset, development and maintenance of static weather in December. Therefore, the Q1 over the western TP and the SST pattern over the western Maritime Continent and western Australia may be potential indicators for the subseasonal prediction of HP in the SCB in December.
Measurement practices of alanine aminotransferase in children: Temporal changes and etiology for increased values
Authors: Aitokari Linnea , Hiltunen Pauliina , Huhtala Heini , Kurppa Kalle , Kivelä Laura 
Published: March 2024

AbstractData on alanine aminotransferase (ALT) measurement practices and diagnoses associated with increased values are limited. We evaluated these issues by collecting ALT measurements from 1‐ to 16‐year‐old patients investigated in 1992–2018 in a tertiary center. Diagnoses were gathered in 2008–2018. Altogether 145,092 measurements from 28,118 children were taken 42% undergoing repeated testing. Testing increased from 21/1000 to 81/1000 children and the prevalence of elevated values fluctuated between 18% and 26%. An increase was seen especially in emergency care and departments of rheumatology, gastroenterology, hemato‐oncology, and psychiatry. Common acute causes associated with elevated ALT were infections (45%), hemato‐oncologic conditions (17%), and external reasons (13%), whereas autoimmune diseases (28%), psychiatric conditions (14%), and metabolic‐dysfunction associated steatotic liver disease (10%) were common chronic causes. In conclusion, ALT testing increased 3.9‐fold while the proportion of increased values remained stable, indicating that increased testing was justified. However, in some departments the testing efficiency was low.
Shwachman–Diamond syndrome mimicking mitochondrial hepatopathy
Authors: Kaufman Odelya , Donnelly Colleen , Cork Emalyn , Fiel Maria I. , Chu Jaime , Ganesh Jaya 
Published: March 2024

AbstractShwachman–Diamond syndrome (SDS) is a genetic disorder caused by mutations in the Shwachman–Bodian–Diamond syndrome (SBDS) gene. The syndrome is characterized by multiorgan dysfunction primarily involving the bone marrow and exocrine pancreas. Frequently overlooked is the hepatic dysfunction seen in early childhood which tends to improve by adulthood. Here, we report a child who initially presented with failure to thrive and elevated transaminases, and was ultimately diagnosed with SDS. A liver biopsy electron micrograph revealed hepatocytes crowded with numerous small mitochondria, resembling the hepatic architecture from patients with inborn errors of metabolism, including mitochondrial diseases. To our knowledge, this is the first report of the mitochondrial phenotype in an SDS patient. These findings are compelling given the recent cellular and molecular research studies which have identified SBDS as an essential regulator of mitochondrial function and have also implicated SBDS in the maintenance of mitochondrial DNA.
Impact of visual enhancement and color conversion algorithms on remote sound recovery from silent videos
Authors: Choong Ren‐Jun , Yap Wun‐She , Hum Yan Chai , Lai Khin Wee , Ling Lloyd , Vodacek Anthony , Tee Yee Kai 
Published: March 2024

AbstractThe visual microphone is a technique for remote sound recovery that extracts sound information from tiny pixel‐scale vibrations in a video. Despite having demonstrated success in sound recovery, the impact of various visual enhancement and color conversion algorithms applied on the video before the sound recovery process has not been explored. Thus, it is important to investigate these effects have on the recovered sound quality, as the vibrations are so small the effects play an important role. This work experimented with different color to grayscale conversions and visual enhancement algorithms on 576 videos, and found that the recovered sound quality is indeed greatly affected by the choice of algorithms. The best conversion algorithms were found to be the average of the red, green and blue color channels and the perceptual lightness in the CIELAB color space, improving the recovered sound quality by up to 23.22%. Furthermore, visual enhancement techniques such as gamma correction have been found to corrupt vibration information, leading to a 22.47% drop in recovered sound quality in one of the tested videos. Therefore, it is advisable to avoid or minimize the use of visual enhancement techniques for remote sound recovery to prevent the elimination of useful subtle vibrations.