bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local circuitry in the anterior caudal lobe of the mormyrid cerebellum: Intracellular recording and labeling
Authors: Zhang Yueping , Han Phil F. , Han Victor Z. 
Published: May 2008

AbstractSagittal view of a Purkinje cell with symmetric dendritic tree from the anterior caudal lobe of the cerebellum of a mormyrid fish (Gnathonemus petersii). The cell was filled with neurobiotin in an in vitro slice preparation and tracer was revealed with red fluorescent dye. Nissl counterstaining is shown in green. The cell was photographed from a slice of 200 μm using a confocal laser scanning microscope. The cell body is located in the anterior border with the eminentia granularis anterior (upper right), and the axon was cut, probably projecting to the brainstem (for details see text). The dendritic tree is planar, extending for 500x700 μm in the sagittal plane, but only for 110 μm (optical thickness) medio‐laterally. Two smooth primary dendrites arise from the soma and give off secondary and tertiary branches irregularly in the molecular region. The dendrites become thinner and more spiny as they extend further from the cell body. J. Comp. Neurol. 509:1–22, 2008. © 2008 Wiley‐Liss, Inc.
Chemical Bonding of Fullerene and Fluorinated Fullerene on Bare and Hydrogenated Diamond
Authors: Ouyang Ti , Loh Kian Ping , Qi Dongchen , Wee Andrew Thye Shen , Nesladek Milos 
Published: May 2008

AbstractWe investigate the interface between a C60 fullerite film, C60F36, and diamond (100) by using core‐level photoemission spectroscopy, cyclic voltammetry (CV), and high‐resolution electron energy loss spectroscopy (HREELS). We show that C60 can be covalently bonded to reconstructed C(100)‐2×1 and that the bonded interface is sufficiently robust to exhibit characteristic C60 redox peaks in solution. The bare diamond surface can be passivated against oxidation and hydrogenation by covalently bound C60. However, C60F36 is not as stable as C60 and desorbs below 300 °C (the latter species being stable up to 500 °C on the diamond surface). Neither C60 fullerite nor C60F36 form reactive interfaces on the hydrogenated surface—they both desorb below 300 °C. The surface transfer doping process of hydrogenated diamond by C60F36 is the most evident one among all the adsorbate systems studied (with a coverage‐dependent band bending induced by C60F36).
Hollow MgO Nanotube Arrays by Using ZnO Nanorods as Templates
Authors: Lu Hong‐Bing , Liao Lei , Li Hua , Wang Duo‐Fa , Tian Yu , Li Jin‐Chai , Fu Qiang , Zhu Ben‐Peng , Wu Yun 
Published: May 2008

AbstractA newly developed solid–gas chemical reaction route has been demonstrated to fabricate MgO nanotube arrays by using prefabricated ZnO nanorods as templates. The formation process involves the Kirkendall effect, in which the out‐diffusion of the ZnO core material through the MgO shells is faster than the in‐diffusion of the vapor‐phase Mg atoms, resulting in the formation of Kirkendall voids, which eventually induces hollow MgO nanotubes. The dimensions and sizes of the obtained MgO nanotubes can be controlled by employing suitable ZnO templates. Other types of complex hollow MgO architectures with different aspect ratios can be further manipulated and fabricated by this method, depending on the morphologies of the starting ZnO nanostructures used as templates. These hollow MgO architectures with high surface‐to‐volume ratios may have promising applications in catalysis, drug delivery, nano‐optics, nanoreactors, and active material encapsulation.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Potentialities of quantile regression to predict ozone concentrations
Authors: Sousa S. I. V. , Pires J. C. M. , Martins F. G. , Pereira M. C. , Alvim‐Ferraz M. C. M. 
Published: May 2008

AbstractThis paper aims: (i) to analyse the influence of ozone precursors (both meteorological variables and pollutant concentrations) on ozone concentrations at different ozone levels; and (ii) to predict next day hourly ozone concentrations using a new approach based on quantile regression (QR). The performance of this model was compared with multiple linear regressions (MLR) for the three following periods: daylight, night time and all day.QR as proven to be an useful mathematical tool to evidence the heterogeneity of ozone predictor influences at different ozone levels. Such heterogeneity is generally hidden when an ordinary least square regression model is applied. The influence of previous concentrations of ozone and nitrogen monoxide on next day ozone concentrations was higher for lower quantiles. When QR was applied, the wind direction (WD) was found to be significant in the medium quantiles and the relative humidity (RH) in the higher quantiles. On the contrary, using the MLR models, both variables were not statistically significant. Moreover, QR allowed more efficient previsions of extreme values which are very useful once the forecasting of higher concentrations is fundamental to develop strategies for protecting the public health. Copyright © 2008 John Wiley & Sons, Ltd.
Weight properties of network codes
Authors: Yang Shenghao , Yeung Raymond W. , Zhang Zhen 
Published: May 2008

AbstractIn this paper, we first study the error correction and detection capability of codesfor a general transmission system inspired by network error correction. For a given weight measure on the error vectors, we define a corresponding minimum weight decoder. Then we obtain a complete characterisation of the capability of a code for (1) error correction; (2) error detection and (3) joint error correctionand detection. Our results show that if the weight measure on the error vectors is the Hamming weight, the capability of a linear code is fully characterised by a single minimum distance. By contrast, for a nonlinear code, two different minimum distances are needed for characterising the capabilities of the code for error correction and for errordetection. This leads to the surprising discovery that for a nonlinear code, the numberof correctable errors can bemore than half of the number of detectable errors. We also present a framework that captures joint error correction and detection. We further define equivalence classes of weight measures with respect to a channel. Specifically, for any given code, the minimum weight decoders for two different weight measures are equivalent if the two weight measures belong to the same equivalence class. In the special case of linear network coding, we study three weight measures, and show that they are inthe same equivalence class of the Hamming weight and induce the same minimum distance as the Hamming weight. Copyright © 2008 John Wiley & Sons, Ltd.
The pattern of depressive symptoms and factor analysis of the Cornell Scale among patients in Norwegian nursing homes
Authors: Barca Maria Lage , Selbæk Geir , Laks Jerson , Engedal Knut 
Published: May 2008

AbstractBackgroundDepression is more prevalent in subjects with dementia than in those without it. Due to both psychological and biological risk factors it is suggested that a bimodal distribution of depressive symptoms exists with higher prevalence rates being found among patients suffering both with mild and with severe dementia.AimTo confirm or reject the hypothesis of a bimodal distribution of depressive symptoms.MethodsA sample of 1,159 randomly selected nursing home patients was assessed using the Cornell Scale, the Clinical Dementia Rating Scale (CDR) and Lawton's Scale of the activities of daily living. Additionally, information was collected from the patients' records. A factor analysis of the Cornell Scale was performed.ResultsThe use of antidepressants and demographic characteristics, except for gender distribution, did not differ across CDR groups. Patients with dementia had more symptoms such as anxiety, irritability, agitation, retardation, loss of interest, lack of joy and delusion than those without dementia. No symptom was more frequent among non‐demented subjects. The factor analysis resulted in a five factors solution: ‘mood’, ‘cyclic’, ‘physical’, ‘retardation’ and ‘behavioural’ factor. The score on the mood subscale did not differ across CDR groups (p = 0.326), whereas the scores on the four other subscales increased with increasing CDR scores (p < 0.001).ConclusionWe did not find a bimodal distribution of depressive symptoms. The explanation for the occurrence of the typical core symptoms of depression, the mood symptoms, is probably complex. The non‐mood symptoms are probably strongly influenced by biological factors. Copyright © 2008 John Wiley & Sons, Ltd.
Should the capability approach be applied in Health Economics?
Authors: Coast Joanna , Smith Richard , Lorgelly Paula 
Published: May 2008

AbstractThis editorial questions the implications of the capability approach for health economics. Two specific issues are considered: the evaluative space of capablities (as opposed to health or utility) and the decision‐making principle of maximisation. The paper argues that the capability approach can provide a richer evaluative space enabling improved evaluation of many interventions. It also argues that more thought is needed about the decision‐making principles both within the capability approach and within health economics more generally. Specifically, researchers should analyse equity‐oriented principles such as equalisation and a ‘decent minimum’ of capability, rather than presuming that the goal must be the maximisation of capability. Copyright © 2008 John Wiley & Sons, Ltd.
Therapy adapted to molecular response in patients with chronic myelogenous leukaemia in first chronic phase: results of the Duesseldorf study
Authors: Neumann Frank , Markett Judith , Fenk Roland , Pooten Monika , Koch Anne , Bruennert Daniela , Schimkus Nadine , Wulfert Michael , Royer‐Pokora Brigitte , Kronenwett Ralf , Haas Rainer , Gattermann Norbert 
Published: May 2008

AbstractThis study evaluates response‐adapted treatment of chronic myelogenous leukaemia (CML) in chronic phase using molecular response criteria. bcr‐abl/G6PDH ratios were assessed by Light‐Cycler quantitative real‐time polymerase chain reaction (PCR( in 277 peripheral blood samples from 33 patients, before and every 3 months during therapy. Sixty‐six per cent (22/33) of the patients fulfiled our molecular response criterion of ≥1 log decrease in bcr‐abl transcript after 6 or ≥2 log decrease after 9 and every following 3 months. Dose escalation was necessary for 33% (11/33) of the patients. Of these, 54% (6/11) achieved a reduction of bcr‐abl mRNA by ≥2 log (n = 3) or ≥3 log (n = 3) with 800 mg Imatinib. Forty‐five per cent (5/11) showed insufficient molecular response with 800 mg Imatinib and received Nilotinib. In conclusion, the assessment of molecular response permits an individual patient‐tailored treatment of CML in first chronic phase, resulting in the majority of patients achieving a major molecular response after 2 years of therapy. Copyright © 2008 John Wiley & Sons, Ltd.
Assessment of NORE1A as a putative tumor suppressor in human neuroblastoma
Authors: Geli Janos , Kogner Per , Lanner Fredrik , Natalishvili Natalia , Juhlin Christofer , Kiss Nimrod , Clark Geoffrey J. , Ekström Tomas J. , Farnebo Filip , Larsson Catharina 
Published: May 2008

AbstractThe putative tumor suppressor NORE1A (RASSF5) is a member of the Ras association domain family and is commonly inactivated in human cancer. The closely related gene family member and functional collaborator RASSF1A is a bona fide tumor suppressor and is frequently involved in neuroblastoma. In the present study, we sought to investigate the role of NORE1A in human neuroblastoma. A panel of tumors (36 neuroblastomas and 4 ganglioneuromas) and neuroblastoma cell lines was assessed for NORE1A gene expression by Taqman quantitative RT‐PCR. Promoter methylation was quantitatively determined by methylation sensitive pyrosequencing. The antitumourigenic role was functionally investigated in Nore1a transfected SK‐N‐BE (2) cells by fluorescent inhibition of caspase activity and BrdU incorporation assays. Neuroblastoma cells showed very low or absent NORE1A mRNA expression, which could not be reversed by trichostatin A or 5‐aza‐cytidine treatments. Neuroblastoma tumors showed suppressed NORE1A gene expression that was particularly pronounced in cases without MYCN amplification or 1p loss. Methylation of the NORE1A promoter was not observed in primary tumors and only one out of seven neuroblastoma cell lines displayed weak partial methylation. Transient expression of Nore1a resulted in enhanced apoptosis and delayed cell cycle progression. In conclusion NORE1A appears to be strongly suppressed in neuroblastic tumors and reconstitution of its expression diminishes the tumorigenic phenotype. Promotor methylation is not a common mechanism responsible for NORE1A transcriptional suppression in this tumor type. © 2008 Wiley‐Liss, Inc.
α1,3 fucosyltransferase‐VII up‐regulates the mRNA of α5 integrin and its biological function
Authors: Wang Qiu‐yan , Zhang Ying , Shen Zong‐hou , Chen Hui‐li 
Published: May 2008

AbstractAfter transfection of α1,3fucosyltransferase (FucT)‐VII cDNA into H7721 human hepatocarcinoma cells, the expression of α5, but not β1 integrin was significantly up‐regulated. This was evidenced by the increase of α5 integrin on cell surface as well as the increase of α5 mRNA and protein in the cells. However, the expressions of sialyl Lewis X (SLex, the product of α1,3FucT‐VII) on both α5 and β1 integrin subunits were unchanged. Concomitantly, the tyrosine autophosphorylated FAK and dephosphorylated Src (FAK and Src involve in the signal transduction of integrin α5β1) were up‐regulated, while the Tyr‐527 phosphorylated Src was down‐regulated. The above‐mentioned alterations were correlated to the expressions of α1,3FucT‐VII in different α1,3FucT‐VII transfected H7721 cell lines. In addition, after α1,3FucT‐VII transfection, cell adhesion to fibronectin (Fn) and chemotaxic cell migration were obviously promoted. The cell adhesion could be blocked by α5 integrin antibody, and cell migration was obviously attenuated by the antibodies to both α5 integrin and SLex. These findings suggest that the increased surface α5 integrin caused by the up‐regulation of α5 mRNA promotes the cell adhesion to Fn, cell migratiom, and Fn‐induced signaling of α5β1 integrin. The up‐regulation of surface SLex originated from the over expression of α1,3FucT‐VII also led to the stimulation of cell migration. This is the first time to report that α1,3FucT‐VII can regulate the mRNA expression of integrin. J. Cell. Biochem. 104: 2078–2090, 2008. © 2008 Wiley‐Liss, Inc.
The adipokine SAA3 is induced by interleukin‐1β in mouse adipocytes
Authors: Sommer Grit , Weise Sebastian , Kralisch Susan , Scherer Philipp E. , Lössner Ulrike , Blüher Matthias , Stumvoll Michael , Fasshauer Mathias 
Published: May 2008

AbstractSerum amyloid A (SAA) 3 has been characterized as an inflammatory adipocyte‐secreted acute‐phase reactant. In the current study, regulation of SAA3 by the proinflammatory and insulin resistance‐inducing cytokine interleukin (IL)‐1β was determined in 3T3‐L1 and brown adipocytes. Interestingly, SAA3 mRNA and protein synthesis were dramatically increased by IL‐1β in a time‐dependent fashion with maximal induction after 24 h. Furthermore, IL‐1β significantly induced SAA3 mRNA expression dose‐dependently with maximal 36.4‐fold upregulation seen at 2 ng/ml effector. Moreover, IL‐1β‐induced SAA3 expression was mediated by nuclear factor‐κB and janus kinase 2. Taken together, our data show a potent upregulation of SAA3 by IL‐1β. J. Cell. Biochem. 104: 2241–2247, 2008. © 2008 Wiley‐Liss, Inc.
Low over‐expression of TNFα in the mouse heart increases contractile performance via TNFR1
Authors: Pinz Ilka , Wax Stephen D. , Anderson Paul , Ingwall Joanne S. 
Published: May 2008

AbstractTNFα is a cytokine wit pleiotropic functions in many organs. In the heart increased TNFα levels are not only associated with heart failure, but also, paradoxically, with protection from ischemic damage. To test whether the protective role of TNFα in the heart is concentration‐dependent, we studied two mouse heart models with low (two‐ to threefold) over‐expression of endogenous TNFα: mice deficient in a translational repressor of TNFα mRNA, TIA‐1−/−, and mice over‐expressing human TNFα. Hearts lacking TIA‐1 were characterized for their endogenous TNFα over‐expression during normal Langendorff perfusion. To define which TNFα receptor mediates cardiac protection, we also used mice lacking the TNFR1 receptor. Contractile function was assessed in isolated hearts perfused in the isovolumic Langendorff mode during and following global no‐flow ischemic stress and in response to varying extracellular [Ca2+] to determine their contractile response and Ca2+ sensitivity. All hearts with low over‐expression of TNFα, independent of human or murine origin, have improved contractile performance and increased Ca2+ sensitivity (by 0.2–0.26 pCa). Hearts lacking TNFR1 have contractile performance equal to wild type hearts. Recovery from ischemia was greater in TIA‐1−/− and was diminished in TNFR1−/−. Better contractile function in TNFα over‐expressing hearts is not due to improved cardiac energetics assessed as [ATP] and glucose uptake or to differences in expression of SERCA2a or calmodulin. We suggest that low levels of TNFα increase the Ca2+ sensitivity of the heart via a TNFR1‐mediated mechanism. J. Cell. Biochem. 105: 99–107, 2008. © 2008 Wiley‐Liss, Inc.
Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins
Authors: Clawson Gary A. , Bui Vuong , Xin Ping , Wang Ning , Pan Weihua 
Published: May 2008

AbstractWe have a long‐standing interest in a nuclear protease which appears to be involved in carcinogenesis. We recently identified the protease as high temperature requirement factor A 1 (HtrA1), also known as Prss11, which is member of an oxidative stress‐response family of proteases. HtrA1 has been classified as a secreted protease involved in TGFβ signaling, but recent work has shown HtrA1 to be a tumor suppressor. Here we show that processed forms of HtrA1 are found intracellularly and intranuclearly, and the active intranuclear form of HtrA1 shows an ∼Mr 29,000. Further, expression of HPV E6/E7 proteins is associated with a post‐transcriptional up‐regulation of HtrA1 (most notably the nuclear form), and HtrA1 is found associated with both HPV E6 and E7 proteins. J. Cell. Biochem. 105: 81–88, 2008. © 2008 Wiley‐Liss, Inc.
The dramatic effect of NH3 co‐ligation on the FE+‐assisted activation of carbon dioxide in the gas phase: From bare metal ions to complexes
Authors: Karipidis Paraskevas A. , Tsipis Constantinos A. 
Published: May 2008

AbstractThe catalytic efficiency of Fe+ ion over the CO2 decomposition in the gas phase has been extensively investigated with the help of electronic structure calculation methods. Potential‐energy profiles for the activation process Fe+ + CO2 → CO + FeO+ along two rival potential reaction paths, namely the insertion and addition pathways, originating from the end‐on κ1‐O and κ2‐O,O coordination modes of CO2 with the metal ion, respectively, have been explored by DFT calculations. For each pathway the potential energy surfaces of the high‐spin sextet (S = 5/2) and the intermediate‐spin quartet (S = 3/2) spin‐states have been explored. The complete energy reaction profile calculated by a combination of ab initio and density functional theory (DFT) computational techniques reveals a two‐state reactivity, involving two spin inversions, for the decomposition process and accounts well for the experimentally observed inertness of bare Fe+ ions towards CO2 activation. Furthermore, the coordination of up to three extra ancillary NH3 ligands with the Fe+ metal ion has been explored and the geometric and energetic reaction profiles of the CO2 activation processes Fe+ + n·NH3 + CO2 → [Fe(NH3)n(CO2)]+ → [Fe(NH3)n(O)(CO)]+ → CO + [Fe(O)(NH3)n]+ (n = 1, 2 or 3) have thoroughly been scrutinized for both the insertion and the addition mechanisms. Inter alia, the geometries and energies of the various states of the [Fe(NH3)n(CO2)]+ and [Fe(NH3)n(O)(CO)]+ complexes are explored and compared. Finally, a detailed analysis of the coordination modes of CO2 in the cationic [Fe(NH3)n(CO2)]+ (n = 0, 1, 2 and 3) complexes is presented. © 2008 Wiley Periodicals, Inc. J Comput Chem, 2008
Alterations in RNA‐binding activities of IRES‐regulatory proteins as a mechanism for physiological variability and pathological dysregulation of IGF‐IR translational control in human breast tumor cells
Authors: Meng Zheng , Jackson Nateka L. , Choi Hyoungsoo , King Peter H. , Emanuel Peter D. , Blume Scott W. 
Published: May 2008

AbstractThe type I insulin‐like growth factor receptor (IGF‐IR) is integrally involved in the control of cellular proliferation and survival. An internal ribosomal entry site (IRES) within the 1,038 nucleotide 5′‐untranslated region of the human IGF‐IR mRNA helps to provide the tight control of IGF‐IR expression necessary for maintenance of normal cellular and tissue homeostasis. The IRES maps to a discrete sequence of 85 nucleotides positioned just upstream of the IGF‐IR initiation codon, allowing the ribosome to bypass the highly structured regions of the 5′‐UTR as well as the upstream open reading frame. The authenticity of the IGF‐IR IRES has been confirmed by its sensitivity to deletion of the promoter from a bicistronic reporter construct, and its resistance in a monocistronic reporter construct to co‐expression of a viral 2A protease. We previously characterized HuR as a potent repressor of IGF‐IR translation. Here we demonstrate that hnRNP C competes with HuR for binding the IGF‐IR 5′‐UTR and enhances IRES‐mediated translation initiation in a concentration‐dependent manner. We observed changes in binding of hnRNP C versus HuR to the IGF‐IR 5′‐UTR in response to physiological alterations in cellular environment or proliferative status. Furthermore, we have found distinct alterations in the pattern of protein binding to the IGF‐IR 5′‐UTR in human breast tumor cells in which IGF‐IR IRES activity and relative translational efficiency are aberrantly increased. These results suggest that dysregulation of the IGF‐IR IRES through changes in the activities of RNA‐binding translation‐regulatory proteins could be responsible for IGF‐IR overexpression in a proportion of human breast tumors. J. Cell. Physiol. 217: 172–183, 2008. © 2008 Wiley‐Liss, Inc.
Cell membrane deformations under magnetic force modulation characterized by optical tracking and non‐interferometric widefield profilometry
Authors: Wang Chun‐Chieh , Jian Hung‐Jhang , Wu Chih‐Wei , Lee Chau‐Hwang 
Published: May 2008

AbstractWe measured cell membrane deformations under the modulation of piconewton magnetic force by using optical tracking and noninterferometric widefield optical profilometry. The magnetic force was applied to fibronectin‐coated paramagnetic beads that bound to transmembrane protein integrins. At an image‐acquisition rate of 20 frame/min, optical tracking provided positioning accuracy better than 70 nm for bead displacements on cell membranes, and optical profilometry obtained membrane topography with 20 nm depth resolution. We elucidated the correlation between the bead movements and membrane deformations. When the magnetic force dominated the bead movements, the membrane arose in front of the bead and the height increased with the bead velocity. On the other hand, when the bead was mainly driven by the cytoskeletons, the membrane profiles showed no relevance to the motion of the bead. In this case, the bead moved faster on smooth membranes. A model based on the dynamics of actin cytoskeletons is proposed to explain these observation results. Microsc. Res. Tech., 2008. © 2008 Wiley‐Liss, Inc.