bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medial vs lateral wall pyriform sinus carcinoma: Implications for management of regional lymphatics
Authors: Johnson Jonas T. , Bacon Geoffrey W. , Myers Eugene N. , Wagner Robin L. 
Published: February 2007

AbstractBackground. Our purpose in performing this review is to analyze the relationship between the anatomic site of hypopharyngeal lesions and the pattern of recurrent disease, particularly cervical recurrence. This clinical information can subsequently be used to influence treatment options.Methods. The records of 169 patients with carcinoma of the hypopharynx treated between 1975 and 1986 were reviewed retrospectively. Patients were classified as having medial wall pyriform sinus disease (MP) lesions, lateral wall pyriform sinus (LP) lesions, posterior wall (PW), or postcricoid (PC) lesions. All patients were followed a minimum of 36 months. Patients with evidence of recurrent carcinoma were characterized according to the site of recurrence.Results. Recurrent carcinoma in the hypopharynx was noted in seven (4%) of 169 patients. Cervical metastases was the sole site of failure in 27 (16%) of 69 patients, whereas distant metastases developed in 25 (15%) of 169 patients. Failure in the contralateral unoperated neck occurred in 14% (10/71) of patients with MP lesions and, in contrast, 5% (4/76) LP patients. This difference was statistically significant (p = 0.04). Radiotherapy was not effective in preventing cervical recurrence in 20 (74%) of 27 overall neck failures and 11 (79%) of 14 contralateral NO neck failures.Conclusion. These data suggest that patients with carcinoma involving the MP are at greater risk for contralateral cervical metastases. We recommend bilateral neck dissection be offered to patients with MP lesions. © 1994 John Wiley & Sons, Inc.
Laryngectomy alone for T3 glottic cancer
Authors: Foote Robert L. , Olsen Kerry D. , Buskirk Steven J. , Stanley Robert J. , Suman Vera J. 
Published: February 2007

AbstractBackground.The long‐term survival of 81 patients with T3 squamous cell carcinoma of the glottic larynx treated with laryngectomy alone is presented and pathologic predictors for cancer recurrence above the clavicles and cancer death are identified.Methods.Clinical records, operative notes, and pathologic slides were reviewed. The major end points were failure above the clavicles, cause‐specific survival, and overall survival. All patients were followed until death or a minimum of 10.8 years.Results.The main pattern of treatment failure was within an undissected ipsilateral or contralateral neck. Subglottic extension and nodal metastases predicted failure above the clavicles and delayed metastasis within an undissected neck. The 5‐year rate of control of disease above the clavicles, cause‐specific survival, and overall survival were 74.1%, 73.7%, and 54.3%, respectively.Conclusions.Patients treated with laryngectomy for T3 glottic cancer who have pathologic evidence of subglottic extension or nodal metastasis are at higher risk for recurrence above the clavicles, particularly within an undissected neck. © 1994 John Wiley & Sons, Inc.
Swallowing of bolus types by postsurgical head and neck cancer patients
Authors: Stachler Robert J. , Hamlet Sandra L. , Mathog Robert H. , Jones Lewis , Heilbrun Lance K. , Manov L. Joan , O'Campo Jesus M. 
Published: February 2007

AbstractBackground. Clinically, head and neck cancer patients with anterior resections have better postoperative outcomes than do patients with posterior resections.Methods. Videofluoroscopy was used to study the swallowing characteristics in postsurgery head and neck cancer patients and normal controls. Most patients received post‐operative radiotherapy and chemotherapy, and no cancer recurrence was noted at the time of study, 4‐8 months post‐treatment. Bolus types included: 3 mL and 10 mL liquid barium, barium paste, and barium‐coated cookie. Temporal measurements and a count of the number of swallows required to ingest each material were made from the video‐taped data. Statistical analysis using an unbalanced univariate repeated measures ANOVA was performed.Results. The major differences were found between bolus types, with few differences noted between surgical groups (anterior vs posterior resections) and normal controls. Patients took longer to ingest viscous material, accomplishing this by multiple piecemeal and clearing swallows. Coordination of mastication and swallowing of the cookie was different between normal and patient groups.Conclusions. Patients who are able to swallow reasonably well postoperatively maintain normal coordination and timing of swallowing activity and do not vary these parameters to compensate for structural inadequacy. Instead, repeated swallows are used. © 1994 John Wiley & Sons, Inc.
Nucleolar organizer regions in follicular tumors of the thyroid
Authors: Shem‐Tov Yosef , Straus Michael , Talmi Yoav P. , Rath‐Wolfsom Lea , Zohar Yuval , Gal Rivka 
Published: February 2007

AbstractBackground. Nucleolar organizer regions (NORs) are loops of ribosomal DNA that occur in nucleoli and that transcribe to ribosomal RNA. NORs have been identified by means of the Ag‐NOR technique in routinely processed tissues, and were found to be of discriminative value between some types of benign and malignant lesions.Methods. Follicular lesions of the thyroid (17 adenomas and 25 carcinomas) were examined. Ten normal thyroids served as the control group. All slides were stained by the Ag‐NOR technique and the number of Ag‐NOR dots were counted in 50 randomly selected cells. The mean number of Ag‐NORs was calculated for each case. Data were statistically analyzed by the Student's unpaired t test.Results. The mean Ag‐NOR counts were statistically higher in follicular carcinomas as compared to either follicular adenomas or the normal thyroid. Higher Ag‐NOR counts were found in the more aggressively behaving tumors.Conclusions. It is suggested that the Ag‐NOR technique could be of use as an adjunct to diagnostic histopathology and as an indicator of biologic behavior in follicular tumors of the thyroid. © 1994 John Wiley & Sons, Inc.
Malignant clear cell hidradenoma of the upper lip
Authors: Orlandi Richard R. , Sercarz Joel A. , Doberneck Susan A. , Calcaterra Thomas C. 
Published: February 2007

AbstractMalignant clear cell hidradenoma is an uncommon tumor of eccrine sweat gland origin that has a predilection for the head and neck. It is characterized by an indolent growth pattern yet frequently recurs following surgical excision and has a high incidence of regional and distant metastases. A case of recurrent malignant clear cell hidradenoma of the upper lip is presented. The lesion was treated with surgical excision followed by radiotherapy. The literature on this rare lesion is reviewed and treatment strategies discussed.
Adenocarcinoma with simultaneous squamous carcinomas of the larynx
Authors: Obermyer Neal E. , Ramadan Hassan H. 
Published: February 2007

AbstractBackground. Primary adenocarcinoma of the larynx is a rare neoplasm. The incidence is reported as less than 1% of all laryngeal neoplasms in multiple series. Simultaneous primary adenocarcinoma and a solitary squamous cell carcinoma of the larynx is even rarer and only one case has been found on review of the literature.Methods. A case report of a 74‐year‐old man with a history of right‐sided throat pain, odynophagia, and progressive hoarseness is presented with a review of the literature pertaining to this unusual case.Results. The patient was found to have three distinctly separate laryngeal lesions on direct laryngoscopy. Histopathologic diagnosis of adenocarcinoma was made on one of the three biopsied sites with the other sites being squamous cell carcinoma. Following Combined radiotherapy and surgical treatment, the patient has remained free of disease.Conclusions. Adenocarcinoma of the larynx is an infrequent and lethal disease. This case report and a review of the literature demonstrate that aggressive surgical management is indicated, although still may not result in improved survival. © 1994 John Wiley & Sons, Inc.
Functional status and coping in patients with oral and pharyngeal cancer before and after surgery
Authors: Langius Ann , Björvell Hjördis , Lind Magnus G. 
Published: February 2007

AbstractBackground. Few studies, prospective or retrospective, exist that describe the quality of life of patients with oral or pharyngeal cancer. This study describes functional status, measured by the sickness impact profile (SIP), and coping, measured by the sense of coherence (SOC) scale, in a group of patients treated by surgery for oral or pharyngeal cancer.Methods. Forty‐two patients, divided into two groups, participated in the study. Twenty‐seven patients completed SIP and SOC scale 12 months after treatment (the 12‐month follow‐up group), and 15 patients completed SIP and SOC scale before surgery and SIP 2‐4 months and 12 months after treatment (the prospective group). The patients were also classified according to the extensiveness of their surgery: minor, moderate, or major.Results. The psychosocial and physical functioning as well as the functions of recreation/pastimes, sleep/rest, home management, work, and eating were rated as being impaired 2‐4 months and also 12 months after treatment. However, the obtained values were spread over a wide range, with large individual differences. Functional limitations were related to more extensive surgery and also to less successful coping.Conclusion. This study reveals the need of individualized rehabilitation for these patients, and that the SIP and the SOC scale may serve as evaluation tools in a rehabilitation program.
Skull base chondroma of extracranial origin
Authors: Sichel Jean‐Yves , Monteil Jean‐Paul , Elidan Josef 
Published: February 2007

AbstractMethods. Two cases of chondroma at the skull base, most probably of extracranial origin, are presented: one at the apex of the petrous pyramid and the other in the infratemporal fossa.Results. In the second case, the surgical findings suggested that the tumor originated in the cartilagineous part of the eustachian tube. The world literature was reviewed and only three cases of extracranial chondromas at the skull base, and ten cases of chondromas of the nasopharynx have been described so far.Conclusions. The potential origins of chondromas at the skull base are discussed: Cartilagineous remnants at the basisphenoid and basiocciput or the cartilagineous part of the eustachian tube seem to be the most probable origin.
Aneurysmal bone cyst of the zygomatic arch
Authors: Page Edwin L. , Peters Glenn E. 
Published: February 2007

AbstractBackground: Aneurysmal bone cysts are rare vascular lesions that are most commonly found in the long bones. They are rare in the head and neck. Only two prior cases of aneurysmal bone cysts of the zygoma have been reported in the world literature.Results: We report a case of aneurysmal bone cyst arising in the zygomatic arch with intracranial extension treated with selective arterial embolization and complete excision via an infratemporal fossa approach. This is the first such case reported in the head and neck surgery literature.Conclusions: Selected cases of aneurysmal bone cyst may be safely treated with selective arterial embolization and complete resection.
Safety of preoperative enoxaparin in head and neck cancer surgery
Authors: Gondret Rémi , Dominici Lionel , Angelard Bruno , Dubos Sylvie , Al‐Rawi Said , Huet Yann , Clergue Francois , Saint‐Guily Jean Lacau 
Published: February 2007

AbstractBackground. Thromboembolism is a risk in major head and neck cancer surgery patients predisposed to thrombosis. This study was designed to determine whether enoxaparin (a low molecular weight heparin) administered prior to surgery induces perioperative bleeding.Methods. Forty patients scheduled for major cervicofacial cancer surgery were randomized in a double‐blind study to receive either 20 mg enoxaparin or placebo, 12 hours before surgery. Blood losses were measured at the end of surgery and 6 hours later.Results. Bleeding was equal in the placebo group and in the enoxaparin group, with losses of 648 ± 106 mL and 602 ± 106 mL (p = 0.76), respectively. Six hours after surgery, blood collected was 159.3 ± 25.7 mL in the placebo group vs 151.4 ± 21 mL in the enoxaparin group (p = 0.81).Conclusion. Preoperative administration of enoxaparin is safe in head and neck cancer surgery, but further studies are required to evaluate its efficacy in preventing thromboembolism. © 1995 Jons Wiley & Sons, Inc.
Linac radiosurgery for locally recurrent nasopharyngeal carcinoma: Rationale and technique
Authors: Buatti John M. , Friedman William A. , Bova Frank J. , Mendenhall William M. 
Published: February 2007

AbstractBackground. Patients with locally recurrent nasopharyngeal carcinoma benefit from reirradiation. A main barrier to successful palliation or cure is dose limitation secondary to normal tissue tolerance. There are many strategies to increase the tolerated dose to the recurrent lesions. Stereotactic radiosurgery for the treatment of these lesions has rarely been reported.Methods. Three patients with recurrent nasopharyngeal carcinoma were treated with linac‐based stereotactic radiosurgery.Results. One patient remained disease‐free 1 year after radiosurgery; the second patient had neurologic deterioration of uncertain etiology (complication vs recurrence) 6 months after radiosurgery; and the third patient had local recurrence 6 months after radiosurgery.Conclusion. Stereotactic radiosurgery can be used to deliver a boost dose of radiation to recurrent nasopharyngeal carcinomas. The technique is increasingly available and may offer some advantages compared with other techniques. Treatment recommendations are presented. © 1995 Jons Wiley & Sons, Inc.
Color doppler imaging for vocal cord palsy
Authors: Ooi London Lucien P. J. , Chan Hsiang Sui , Soo Khee Chee 
Published: February 2007

AbstractBackground. Conventional techniques of laryngoscopy for vocal cord palsy can sometimes be difficult or impossible to perform, and B‐mode real‐time ultrasonography has been previously reported by the authors to be helpful in these situations. In some cases, however, B‐mode ultrasonography can be inconclusive. We investigated whether color Doppler imaging can significantly improve vocal cord examination in these cases.Method. Ten normal volunteers were examined using the Acuson 128XP/5 with a 7‐MHz L7384 linear transducer. The thyroid cartilage was used as an acoustic window. Several distinct color flow patterns were observed with the subjects breathing quietly at rest, at the start of vocalization, and in prolonged phonation. Eight patients with hoarseness of voice were then examined by two separate observers in a double‐blinded fashion. The first observer performed B‐mode ultrasonography and color Doppler imaging, while the second observer performed indirect laryngoscopy and direct fiberoptic laryngoscopy.Results. Laryngoscopy was used as the standard for comparison. B‐mode real‐time ultrasonography correctly identified vocal cord palsy in three patients and normal vocal cords in one. The remaining four patients were reported as equivocal or normal. Color Doppler imaging correctly identified the problem in all eight patients.Conclusion. Color Doppler imaging for vocal cord examination is more sensitive than B‐mode real‐time ultrasonography, and seems to be as accurate as laryngoscopy in determining vocal cord palsy or paresis. © 1995 Jons Wiley & Sons, Inc.
DNA content in adenoid cystic carcinomas
Authors: Franzén Gunnar , Nordgård Ståle , Boysen Morten , Larsen Petter L. , Halvorsen Tore B. , Clausen Ole P. F. 
Published: February 2007

AbstractBackground. A retrospective study was performed on 51 patients with adenoid cystic carcinomas to see whether DNA ploidy, tumor stage, and histopathologic grading correlated with prognosis.Methods. Histopathologic grading was performed according to Szanto et al and DNA content was estimated from archived material using the technique by Hedley et al.Results. Thirty‐nine tumors were DNA diploid and 12 were DNA aneuploid. Histologic grade III was more often associated with DNA aneuploidy than the lower grades (p = 0.011). DNA ploidy also correlated with clinical stage (p = 0.011). Log‐rank analysis and Cox regression analysis of treatment failures revealed significant findings for S‐phase value and DNA ploidy.Conclusions. Our results indicate that DNA ploidy estimations, S‐phase value, and histologic grading are prognostic factors in adenoid cystic carcinomas. These examinations should therefore be incorporated in the evaluation of patients with adenoid cystic carcinomas. © 1995 Jons Wiley & Sons, Inc.
In situ skin grafting of free muscle flaps prior to microvascular transfer to provide intraoral lining for full‐thickness defects
Authors: Netscher David T. , Wigoda Paul , Alford Eugene L. 
Published: February 2007

AbstractBackground. Previously, the importance of providing skin for intraoral lining for full‐thickness mucocutaneous defects has been emphasized. More recently, simple skin grafting of the intraoral portion of muscle flaps has been described.Methods. Six patients were evaluated who had full‐thickness mucocutaneous defects reconstructed by means of free muscle flaps with skin grafting of the intraoral muscle surface. An illustrative case is provided. A technique of preplacing the skin graft on the muscle prior to microvascular transfer is described. Mucosal biopsies were performed at the reconstruction site.Results. All patients had complete take of the skin grafts. No fistulas occurred. Functional and esthetic results were satisfactory.Conclusions. The ideal candidate for this form of reconstruction is one in whom there is a large, full‐thickness mucocutaneous defect. Preplacement of the skin graft reduces ischemia time, allows suturing of the skin graft to the muscle surface outside the narrow confines of the oral cavity, and enables placement of multiple quilting sutures that secure the graft against shear forces and so obviate the need for a stent dressing. © 1995 Jons Wiley & Sons, Inc.
Kaposi's sarcoma of the oral cavity in a non‐aids patient: Case report and review of the literature
Authors: Jindal Jay R. , Campbell Bruce H. , Ward Timothy O. , Almagro Urias S. 
Published: February 2007

AbstractBackground. Not every patient with Kaposi's sarcoma (KS) has acquired immunodeficiency syndrome (AIDS). The “classic” form of KS is rare, and is associated with an indolent course. It is very distinct from AIDS‐associated KS in which oral involvement is common and may be the initial presenting feature of this disease. Two other types of KS are recognized, the African and renal transplant‐associated, which also are rarely associated with oral involvement.Methods. We present the case of a 76‐year‐old man of Mediterranean ancestry who was found to have a biopsyproven classical KS lesion of the hard palate. The patient was followed by the Radiation Therapy and Otolaryngology Services during and after his treatment. A review of the literature was also conducted.Results. Radiotherapy was ineffective at a dose considered “standard” for KS in AIDS patients (1,500 cGy), but was effective when continued to 4,800 cGy. A 24‐month follow‐up showed no evidence of recurrence in the oral cavity.Conclusions. KS of the oral cavity, is almost always associated with AIDS in the United States, However, it can occur in any of the four types of KS. Although this neoplasm is typically highly radiosensitive, the treatment for each patient needs to be individualized. © 1995 Jons Wiley & Sons, Inc.
Cytogenetic analysis of tissues from patients with familial paragangliomas of the head and neck
Authors: Zaslav Ann‐Leslie , Myssiorek David , Mucia Christina , Fox Joyce E. 
Published: February 2007

AbstractBackground. Paragangliomas of the head and neck are slow‐growing tumors that originate from neural crest cells. Between 7% and 9% of these tumors have a familial occurrence. The suspected gene for familial paragangliomas (FP) is transmitted with an autosomal dominant mode of inheritance with incomplete penetrance, and appears to exhibit genomic imprinting. It has been demonstrated by family studies that individuals who inherit the gene(s) from their father will develop the disease. Through linkage analysis, the gene(s) for FP has been postulated to be located on the long arm of chromosome 11. The discovery of many different genes has been elucidated through the cytogenetic analysis of affected individuals who carry specific chromosome aberrations. This project was designed to look for chromosome abnormalities in several second‐generation family members to further assist in the localization of the gene(s) for FP.Methods. This study involved the cytogenetic evaluation of lymphocytes, fibroblasts, and tumor cells of several second‐generation family members from a three‐generation family with FP of the head and neck to look for chromosome abnormalities generally, and for abnormalities of chromosome 11 specifically. Standard cytogenetic techniques were used for lymphocyte and fibroblast cultures. Tumor cells were cultured in a collagen matrix with F12 medium supplemented with 3% L‐glutamine and 10% fetal calf serum.Results. There were no detectable abnormalities of chromosome 11 in any of the cells. However, nonrandom abnormalities of chromosomes 5 and 7 were seen in some of the tumor cells of one FP patient. To our knowledge, this is the first article which demonstrated the ability to successfully culture FP of the head and neck. © 1995 Jons Wiley & Sons, Inc.
Papillary thyroid carcinoma mistaken for malignant melanoma: Pitfalls in diagnosis
Authors: Orloff Lisa A. , Weymuller Ernest A. , Flaherty Michael J. 
Published: February 2007

AbstractBackground. Immunohistochemical methods and aspiration cytology are used with increasing frequency in the diagnosis of head and neck histopathology. Magnetic resonance imaging is also gaining popularity as a diagnostic tool.Methods. We report a case of papillary thyroid carcinoma which was initially misdiagnosed as malignant melanoma due to several confounding diagnostic test results.Results. False‐positive immunostaining of a cytologic preparation with a commercial preparation of HMB45 melanoma stain and characteristic MRI findings contributed to the erroneous diagnosis of malignant melanoma.Conclusions. Potential pitfalls in test interpretation are discussed, and recommendations for the judicious use of immunostaining, MRI, and other diagnostic studies are presented. © 1995 Jons Wiley & Sons, Inc.