bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiative Majorana neutrino masses in a parity solution to the strong CP problem
Authors: Hall Lawrence J. , Harigaya Keisuke , Shpilman Yogev 
Published: March 2024

Abstract
The strong CP problem is solved in Parity symmetric theories, with the electroweak gauge group containing SU(2)L × SU(2)R broken by the minimal set of Higgs fields. Neutrino masses may be explained by adding the same number of gauge singlet fermions as the number of generations. The neutrino masses vanish at tree-level and are only radiatively generated, leading to larger couplings of right-handed neutrinos to Standard Model particles than with the tree-level seesaw mechanism. We compute these radiative corrections and the mixing angles between left- and right-handed neutrinos. We discuss sensitivities to these right-handed neutrinos from a variety of future experiments that search for heavy neutral leptons with masses from tens of MeV to the multi-TeV scale.
Bergung eines Fetus während einer Obduktion (der Mutter) mit einem Gewicht unter 500 g, aber einem Schwangerschaftsalter von mehr als 24 Wochen – Totgeburt oder Fehlgeburt?
Authors: Gehrels Doreen , Kölzer Sarah C. , Chabiera Peter Jan , Kettner Mattias , Verhoff Marcel A. 
Published: March 2024

ZusammenfassungIm Rahmen der Obduktion des Leichnams einer angeblich im 7. Monat Schwangeren wurde ein toter Fetus geborgen. Dieser war durch Fäulnis und Madenfraß stark verändert und wog 405 g, wobei in Anbetracht des zu Verlust gegangenen Gewebes von einem Gewicht zum Zeitpunkt des Todes über 500 g auszugehen war. Die übrigen erhobenen Maße sprachen wenigstens für ein Erreichen der 26. Schwangerschaftswoche. Dennoch wurde aufgrund des Gewichts eine Einordnung als Fehlgeburt vorgenommen. Gemäß dem später, am 01.11.2018, geänderten § 31 PStV wäre eine Klassifikation als Totgeburt möglich geworden.
Demazure crystals and the Schur positivity of Catalan functions
Authors: Blasiak Jonah , Morse Jennifer , Pun Anna 
Published: March 2024

AbstractCatalan functions, the graded Euler characteristics of certain vector bundles on the flag variety, are a rich class of symmetric functions which include $k$
k
-Schur functions and parabolic Hall-Littlewood polynomials. We prove that Catalan functions indexed by partition weight are the characters of $U_{q}(\widehat{\mathfrak{sl}}_{\ell })$

U
q

(

sl
ˆ

ℓ

)
-generalized Demazure crystals as studied by Lakshmibai-Littelmann-Magyar and Naoi. We obtain Schur positive formulas for these functions, settling conjectures of Chen-Haiman and Shimozono-Weyman. Our approach more generally gives key positive formulas for graded Euler characteristics of certain vector bundles on Schubert varieties by matching them to characters of generalized Demazure crystals.
Discovering new living Pinna nobilis populations in the Sea of Marmara
Authors: Karadurmuş Uğur , Benli Tacan , Sarı Mustafa 
Published: March 2024

AbstractFan mussel (Pinna nobilis) is one of the largest bivalve species in the Mediterranean Sea. The situation of the species is critical as it faces widespread mass mortality attributed to pathogens in various parts of the Mediterranean Sea. The Sea of Marmara (SoM) offers a unique environment for fan mussel populations, with some areas hosting alive populations. This study aims to explore and describe new P. nobilis populations in the SoM that are known to be not affected by mortality. An area of 28,200 m2 at 47 stations along the 105 km coastline in the southern part of the SoM was explored using underwater visual transects. A total of 544 alive fan mussels were recorded during the underwater surveys, ranging in total shell height from 11.8 to 31.4 cm. The mean density was estimated as 5.3 ind 100 m−2 although maxima of 18.8 ind 100 m−2 were recorded in some stations. These density hotspots were distributed from the shoreline to a 10 m depth range and 100 m distance from the shoreline in sandy and seagrass meadow habitats. The presence of juveniles provided evidence of successful recruitment. The distribution pattern and recorded mortalities were attributed to hydrodynamic factors and intense human activities. Potential environmental factors (low salinity and temperature) in the SoM may control or delay the possible spread of the lethal pathogens. Favorable conditions result in mussels’ resilience and survival mechanisms. The SoM offer a promising larval reservoir for the recolonization of affected areas, such as those found in the Aegean Sea, through larval exportation.
The Livestock Frontier in the Paraguayan Chaco: A Local Agent-based Perspective
Authors: Milán María José , González Elizabeth , López-i-Gelats Feliu 
Published: March 2024

AbstractDeforestation is one of the most relevant transformations characterizing global environmental change in the tropics at present. There is wide consensus in pointing the context-dependent nature of tropical deforestation. In this sense, a better characterization of the phenomenon considering the social context could provide a more accurate picture of tropical deforestation. With this aim, a Q-methodology discourse analysis was conducted to characterise the different discourses that coexist in the particular region of the Paraguayan Chaco concerning the development of cattle ranching and derived deforestation. Four different discourses were identified as making sense the wide range of interests and values coexisting and clashing in the Paraguayan Chaco, namely: the Environmentalist discourse, the Business discourse, the Resigned discourse, and the Possibilist discourse. The results point that the fundamental differences between the discourses are largely explained by the different positions on three specific domains: (i) the socio-economic benefits the expansion of cattle ranching brings about; (ii) the environmental impacts the expansion of cattle ranching and the derived deforestation brings on; and, finally (iii) the degree to which an active intervention from the side of policy making to regulate the expansion of cattle ranching and to minimize possible detrimental effects is seen as necessary. The position of the different discourses in relation to these domains could help policy makers to make measures and regulations more widely accepted and followed.
Baricitinib for anti-melanoma differentiation-associated protein 5 antibody-positive dermatomyositis-associated interstitial lung disease: a case series and literature review on Janus kinase inhibitors for the disease
Authors: Harada Hiroaki , Shoda Hirofumi , Tsuchiya Haruka , Misaki Makoto , Sawada Takayuki , Fujio Keishi 
Published: March 2024

AbstractAnti-melanoma differentiation-associated protein 5 antibody-positive dermatomyositis (anti-MDA5-DM) is frequently complicated by progressive interstitial lung disease (ILD), the prognosis of which is poor, and management is a major challenge. We treated three patients with anti-MDA5-DM-associated ILD (anti-MDA5-DM-ILD) using the Janus kinase (JAK) inhibitor, baricitinib, which improved lung opacities and saved two patients. We reviewed 6 patients with anti-MDA5-DM-ILD who had been treated with tofacitinib at our institution. Five of the patients survived, although discontinuation of tofacitinib due to complications was frequently observed. In addition, a literature search of patients with anti-MDA5-DM-ILD who were treated with JAK inhibitors yielded 21 articles involving 79 cases. All patients except one were treated with tofacitinib, and the survival rate was 75.9%. Although not statistically confirmed, the deceased patients tended to be older and had higher ferritin levels. A total of 92 complications were observed, 11 of which resulted in JAK inhibitor discontinuation. Cytomegalovirus reactivation comprised a substantial percentage of all complications and of those patients who required JAK inhibitor discontinuation. Five cases with fatal infective complications were also observed. While tofacitinib has been proposed to be a therapeutic option for anti-MDA5-DM-ILD, other JAK inhibitors, including baricitinib, are a treatment option. Further investigation is warranted to optimize treatment of anti-MDA5-DM-ILD.
Altered probe pressure and body position increase diagnostic accuracy for men and women in detecting hepatic steatosis using quantitative ultrasound
Authors: Byenfeldt Marie , Kihlberg Johan , Nasr Patrik , Grönlund Christer , Lindam Anna , Bartholomä Wolf C. , Lundberg Peter , Ekstedt Mattias 
Published: March 2024

Abstract
Objectives
To evaluate the diagnostic performance of ultrasound guided attenuation parameter (UGAP) for evaluating liver fat content with different probe forces and body positions, in relation to sex, and compared with proton density fat fraction (PDFF).

Methods
We prospectively enrolled a metabolic dysfunction-associated steatotic liver disease (MASLD) cohort that underwent UGAP and PDFF in the autumn of 2022. Mean UGAP values were obtained in supine and 30° left decubitus body position with normal 4 N and increased 30 N probe force. The diagnostic performance was evaluated by the area under the receiver operating characteristic curve (AUC).

Results
Among 60 individuals (mean age 52.9 years, SD 12.9; 30 men), we found the best diagnostic performance with increased probe force in 30° left decubitus position (AUC 0.90; 95% CI 0.82–0.98) with a cut-off of 0.58 dB/cm/MHz. For men, the best performance was in supine (AUC 0.91; 95% CI 0.81–1.00) with a cut-off of 0.60 dB/cm/MHz, and for women, 30° left decubitus position (AUC 0.93; 95% CI 0.83–1.00), with a cut-off 0.56 dB/cm/MHz, and increased 30 N probe force for both genders. No difference was in the mean UGAP value when altering body position. UGAP showed good to excellent intra-reproducibility (Intra-class correlation 0.872; 95% CI 0.794–0.921).

Conclusion
UGAP provides excellent diagnostic performance to detect liver fat content in metabolic dysfunction-associated steatotic liver diseases, with good to excellent intra-reproducibility. Regardless of sex, the highest diagnostic accuracy is achieved with increased probe force with men in supine and women in 30° left decubitus position, yielding different cut-offs.

Clinical relevance statement
The ultrasound method ultrasound-guided attenuation parameter shows excellent diagnostic accuracy and performs with good to excellent reproducibility. There is a possibility to alter body position and increase probe pressure, and different performances for men and women should be considered for the highest accuracy.

Key Points
• There is a possibility to alter body position when performing the ultrasound method ultrasound-guided attenuation parameter.
• Increase probe pressure for the highest accuracy.
• Different performances for men and women should be considered.

Graphical Abstract
Introduction, spread and selective breeding of crops: new archaeobotanical data from southern Italy in the early Middle Ages
Authors: Fiorentino Girolamo , Grasso Anna Maria , Primavera Milena 
Published: March 2024

AbstractThis paper presents a summary of the record of the cultivated plant macroremains from southern Italy during the early Middle Ages, with a focus on the recent discoveries of crop remains in Sicily. These have shed light on the introduction of new plants in the central Mediterranean region at ca. 500–1100ce. Specifically, we are dealing with the first evidence of the adoption of two new varieties of crops, one of flax (Linum usitatissimumcf. conv.mediterraneum) and the other of broad (or faba) bean (Vicia fabacf. var.equina) during the 8th century, a period of Byzantine domination, and also the introduction of exotic plants such asSolanum melongena(aubergine) andGossypium herbaceum/arboreum(cotton) following the Islamic conquest. In some cases these developments were to have long term impacts, for example in Sicily with regard to cotton, which became an important cash crop there in the 13th century, and throughout southern Italy with regard to a new variety ofVicia faba(Vicia fabacf. var.major), which was grown in Puglia from the late Middle Ages onwards.
Die Subanalyse von Rheuma-VOR zeigt den erheblichen Bedarf der rheumatologischen Versorgung auf
Authors: Hirsch Stefanie , Hoeper K. , Meyer-Olson D. , Schwarting A. , Gente K. , Dreher M. , Hoeper J. , Witte T. , Thiele T. 
Published: March 2024

Zusammenfassung
Hintergrund
Eine frühe Diagnose und Behandlung entzündlich-rheumatischer Erkrankungen kann Folgeschäden wie dauerhafte Einschränkungen der Mobilität und Gelenk- oder Organschäden verhindern. Gleichzeitig besteht ein größer werdendes Versorgungsdefizit aufgrund fehlender rheumatologischer Kapazitäten. Betroffen sind besonders die ländlichen Regionen.

Ziel der Arbeit
Die vorliegenden nicht bestätigten Diagnosen der Studie Rheuma-VOR wurden hinsichtlich des Vorliegens einer anderen definitiven entzündlich-rheumatischen Erkrankung analysiert.

Material und Methoden
Die eingegangenen Fragebögen der an der Rheuma-VOR-Studie teilnehmenden Rheumatolog:innen wurden nach Vermerken anderer entzündlich-rheumatischer Erkrankungen als der geforderten Diagnose einer rheumatoiden Arthritis, Psoriasis-Arthritis oder Spondyloarthritis gescreent.

Ergebnisse
Von 910 „nicht bestätigten“ Diagnosen waren bei 245 Patient:innen andere gestellte Diagnosen auszuwerten. Insgesamt 29,8 % der Diagnosen entsprechen degenerativen Gelenkveränderungen oder chronischen Schmerzsyndromen, bei 26,1 % lagen verschiedene Formen entzündlicher Arthritiden vor. Der Großteil der Diagnosen (40,5 %) entfiel auf Kollagenosen und Vaskulitiden, wobei die Polymyalgia rheumatica mit 20 % am häufigsten diagnostiziert wurde (49 Patient:innen).

Diskussion
Die vorliegenden Daten zeigen, dass bei einem Großteil der Patient:innen die rheumatologische Vorstellung indiziert war. Aufgrund der ambulanten Versorgungsdefizite ist eine vorherige Selektion des Patientenguts essenziell, um die eingeschränkten Kapazitäten bestmöglich zu nutzen.
Investigation of lacrimal gland and extraocular muscle in thyroid eye disease patients with severe subjective dry eye disease: a multiparametric magnetic resonance imaging study
Authors: Liao Xulin , Aljufairi Fatema Mohamed Ali Abdulla , Sebastian Jake Uy , Jia Ruofan , Wong Hanson Yiu Man , Lai Kenneth Ka Hei , Chen Wanxue , Hu Zhichao , Wei Yingying , Chu Winnie Chiu Wing , Tham Clement Chee Yung , Pang Chi Pui , Chong Kelvin Kam Lung 
Published: March 2024

Abstract
Purpose
To analyze the radiological features of the lacrimal gland (LG) and extraocular muscle (EOM) in thyroid eye disease (TED) patients with severe subjective dry eye disease (DED) using magnetic resonance imaging (MRI) measurements.

Methods
In this cross-sectional study, mechanical ocular exposure, dry eye assessment and MRI data were collected. Patients were classified into non-severe subjective DED group with ocular surface disease index (OSDI) < 33 and severe subjective DED group with OSDI ≥ 33. Linear regression model was applied for comparing the OSDI < 33 and OSDI ≥ 33 group in TED patients. The predictive performance of MRI parameters and models was assessed by receiver operating characteristic curve (ROC) analysis.

Results
Consecutive 88 TED patients (176 eyes) were included in this study. In the OSDI < 33 group, 52 TED patients (104 eyes) with a mean clinical activity score (CAS) of 0.63 ± 0.75. In the OSDI ≥ 33 group, there are 36 TED patients (72 eyes), with a mean CAS of 1.50 ± 1.54. The age and sex of the patients were matched between the two groups. The OSDI ≥ 33 group had shorter tear break-up time, larger levator palpebrae superioris / superior rectus (LPS/SR), inferior rectus and lateral rectus, smaller LG, more inflammatory LPS/SR and inferior rectus than OSDI < 33 DED group (P < 0.05). In the linear regression analysis, compare to the OSDI < 33 DED group, the OSDI ≥ 33 group had larger medial rectus cross-sectional area (β = 0.06, 95%CI: (0.02, 0.10), P = 0.008), larger inferior rectus cross-sectional area (β = 0.06, 95%CI: (0.00, 0.12), P = 0.048), smaller LG cross-sectional area (β = -0.14, 95%CI: (-0.25, -0.04), P = 0.008). In the ROC analysis, the area under curve of medial rectus, inferior rectus, LG, and combined model are 0.625, 0.640, 0.661 and 0.716, respectively.

Conclusion
Multiparametric MRI parameters of the LG and EOM in TED patients with severe subjective DED were significantly altered. Novel models combining the cross-sectional area of LG, medial rectus and inferior rectus showed good predictive performance in TED patients with severe subjective DED.
Glucose ingestion before and after resistance training sessions does not augment ribosome biogenesis in healthy moderately trained young adults
Authors: Lian Kristian , Hammarström Daniel , Hamarsland Håvard , Mølmen Knut Sindre , Moen Sara Christine , Ellefsen Stian 
Published: March 2024

Abstract
Purpose
Resistance training-induced skeletal muscle hypertrophy seems to depend on ribosome biogenesis and content. High glucose treatment may augment ribosome biogenesis through potentiating resistance training-induced adaptations. This was investigated with total RNA and ribosomal RNA abundances as main outcomes, with relevant transcriptional/translational regulators (c-Myc/UBF/rpS6) as a secondary outcome.

Methods
Sixteen healthy, moderately trained individuals [male/female, n = 9/7; age, 24.1 (3.3)] participated in a within-participant crossover trial with unilateral resistance training (leg press and knee extension, 3 sets of 10 repetitions maximum) and pre- and post-exercise ingestion of either glucose (3 × 30 g, 90 g total) or placebo supplements (Stevia rebaudiana, 3 × 0.3 g, 0.9 g total), together with protein (2 × 25 g, 50 g total), on alternating days for 12 days. Six morning resistance exercise sessions were conducted per condition, and the sessions were performed in an otherwise fasted state. Micro-biopsies were sampled from m. vastus lateralis before and after the intervention.

Results
Glucose ingestion did not have beneficial effects on resistance training-induced increases of ribosomal content (mean difference 7.6% [− 7.2, 24.9], p = 0.34; ribosomal RNA, 47S/18S/28S/5.8S/5S, range 7.6–37.9%, p = 0.40–0.98) or levels of relevant transcriptional or translational regulators (c-MYK/UBF/rpS6, p = 0.094–0.292). Of note, both baseline and trained state data of total RNA showed a linear relationship with UBF; a ∼14% increase in total RNA corresponded to 1 SD unit increase in UBF (p = 0.003).

Conclusion
Glucose ingestion before and after resistance training sessions did not augment ribosomal RNA accumulation during twelve days of heavy-load resistance training in moderately trained young adults.
The emergence of the Medical University of Vienna 20 years ago
Authors: Schütz Wolfgang , Grimm Markus 
Published: March 2024

SummaryAt the beginning of the 2000s the Austrian public universities were characterized by staffing rigidities, little competitive research, outdated study curricula and free access to all fields of study, the latter combined with high dropout rates and long study durations. As a countermeasure the universities were granted full legal capacity. For new employees the status of civil servants was herewith cancelled and, being now subject to the Employment Act, tenured employments for anyone who wanted to stay at the university were no longer possible. Medical faculties always had special provisions which would be difficult to reconcile with the full legal capacity of the universities: (i) the requirements of the hospitals affiliated to universities for research and teaching in addition to patient care had to be reimbursed to the Austrian federal states maintaining the hospitals, (ii) the physicians of university-affiliated hospitals were largely employed by the respective university and (iii) to ensure financing of clinical research and teaching at the hospital, the medical faculties received a budget separated from the rest of the university. As it was neither politically possible nor foreseeable that universities would be able to form a subcorporation with the affiliated hospital (integration model) or at least a close cooperation with the hospital if that has legal capacity per se (cooperation model), the necessary budgetary sovereignty of the medical faculties could only be guaranteed by their transition to medical universities. Nonetheless, reservations about this spin-off of medicine were enormous, but quickly fell silent, as the newly established medical universities maintained close cooperations with their parent as well as other universities and achieved, for Austrian standards, favorable positions in international rankings.
Are there gender-specific differences in hip and knee cartilage composition and degeneration? A systematic literature review
Authors: Di Martino Alberto , Barile Francesca , D’Agostino Claudio , Castafaro Vanita , Cerasoli Tosca , Mora Paolo , Ruffilli Alberto , Traina Francesco , Faldini Cesare 
Published: March 2024

AbstractThe aim of the present review is to systematically analyse the current literature about gender differences in hip or knee cartilage composition and degeneration, to help explaining how and why osteoarthritis affects women more often and more severely than men. A systematic review of the literature in English was performed. Eleven studies on 1962 patients (905 females and 787 males) that reported differences on cartilage composition between males and females were included. Nine evaluated the knee, one the hip, and one both. They were heterogeneous in their methods: one conducted histological analyses, and all the others evaluated cartilage characteristics (volume, width, and composition) through magnetic resonance imaging. All authors reported gender differences in both volume and morphology of the cartilage, from infancy to menopause. In fact, a study on 92 healthy children statistically showed significant gender differences in cartilage thickness at all sites, even after adjustment for age, body, and bone size. Gender differences become more evident after menopause, when women have a lower cartilage volume and a higher cartilage loss. Men show significantly higher knee and hip cartilage volumes than women, and women carry a significantly greater risk to develop osteoarthritis. This is in part due to body and bone size, but also depends on qualitative and quantitative differences in the composition of cartilage and its degeneration rate after menopause. Structural changes in cartilage that occur between genders during ageing have significance in the development of osteoarthritis.
The legal incidence of ad valorem taxes matters
Authors: Pauwels Wilfried , Schroyen Fred 
Published: March 2024

AbstractIt is well known that, for a specific tax, its economic incidence does not depend on which side of the market has the legal obligation to pay the tax. In this paper, we show that, for an ad valorem tax, this legal incidence does matter for the economic incidence. In particular, when a government imposes an ad valorem tax rate on the sale of a commodity, the resulting reduction in the market equilibrium level of sales will be larger when sellers are obliged to pay the tax than when buyers are obliged to pay the tax.