bluuebunny/crossref_metadata_2025_split huggingface dataset:
The August 2010 Phreatic Eruption of Mount Sinabung, North Sumatra
Authors: Sutawidjaja Igan S. , Prambada O. , Siregar D. A. 
Published: March 2024

DOI: 10.17014/ijog.v8i1.155Mount Sinabung, located in Karo Regency, North Sumatra Province, is a strato volcano having four active craters. Since its latest eruption about 1,200 year ago, a phreatic eruption occurred on August 27th, 2010. The eruption took place in Crater-I, which was initiated by a greyish white plume and then followed by black plumes as high as 2000 m above the crater. Altered rock fragments and ash were erupted during this event. The altered rocks show a development of argillic alterations which was formed in the hydrothermal system in depth. The alteration zone is formed along the northeast-southwest and northwest-southeast trend across the three craters. All of the craters are actively discharging solfataric gases, of which sulphur deposits are resulted, and they have been quarried by the local people. The age of the latest magmatic eruption was dated by 14C method from the charcoal sample found in the pyroclastic flow deposits near Bekerah Village.
Paleogene Sediment Character of Mountain Front Central Sumatra Basin
Authors: Suandhi P. A. , Rozalli M. , Utomo W. , Budiman A. , Bachtiar A. 
Published: March 2024

DOI: 10.17014/ijog.v8i3.164The SE-NW trending Mountain Front of Central Sumatra Basin is located in the southern part of the basin. The Mountain Front is elongated parallel to the Bukit Barisan Mountain, extending from the Regencies of North Padang Lawas (Gunung Tua in the northwest), Rokan Hulu, Kampar, Kuantan Singingi, and Inderagiri Hulu Regency in the southeast. The Palaeogene sediments also represent potential exploration objectives in Central Sumatra Basin, especially in the mountain front area. Limited detailed Palaeogene sedimentology information cause difficulties in hydrocarbon exploration in this area. Latest age information and attractive sediment characters based on recent geological fieldwork (by chaining method) infer Palaeogene sediment potential of the area. The Palaeogene sedimentary rock of the mountain front is elongated from northwest to southeast. Thickness of the sedimentary unit varies between 240 - 900 m. Palynology samples collected recently indicate that the oldest sedimentary unit is Middle Eocene and the youngest one is Late Oligocene. This latest age information will certainly cause significant changes to the existing surface geological map of the mountain front area. Generally, the Palaeogene sediments of the mountain front area are syn-rift sediments. The lower part of the Palaeogene deposit consists of fluvial facies of alluvial fan and braided river facies sediments. The middle part consists of fluvial meandering facies, lacustrine delta facies, and turbidity lacustrine facies sediments. The upper part consists of fluvial braided facies and transitional marine facies sediments. Volcanism in the area is detected from the occurrence of volcanic material as lithic material and spotted bentonite layers in the middle part of the mountain front area. Late rifting phase is indicated by the presence of transitional marine facies in the upper part of the Palaeogene sediments.
Characteristics of Paleotsunami Sediments, A Case Study in Cilacap and Pangandaran Coastal Areas, Jawa, Indonesia
Authors: Yudhicara Yudhicara , Zaim Y. , Rizal Y. , Aswan Aswan , Triyono R. , Setiyono U. , Hartanto D. 
Published: March 2024

DOI: 10.17014/ijog.v8i4.166A paleotsunami study having been conducted in 2011 took two study cases in Cilacap and Pangandaran coastal areas. These two regions have been devastated by tsunami in the past and had the most severe damaged on 17 July 2006. Trenching, beach profiling, and sediment sampling had been carried out, and further analysis at the laboratory had been done, such as grain size and fossil analyses and dating. In Cilacap, an iron sand layer was found as a key bed suspected as a paleotsunami deposits due to the content of anthropogenic fragments. In Pangandaran, two layers of tsunami deposit candidates were found having thickness of 5 - 6 cm at the top as a 2006 tsunami deposit candidate, and 5 - 10 cm at the bottom as a paleotsunami deposit candidate. Both grain size and fossil analysis results could explain that Pangandaran’s sediments are tsunami deposits while Cilacap’s ones are assumed to be deposited by another process rather than a tsunami.
EFFECTIVE WHITEBOARD AS LEARNING MEDIA FOR HYBRID LEARNING SYSTEM IN HIGH SCHOOL
Authors: Widyastuti Alfina Mutiara , Zahra Alya Fauzia , Erdiyana Sintiya , Haristianti Vika 
Published: March 2024

At the beginning of 2020, COVID-19 was a virus that spread and occurred simultaneously in various countries around the world, including Indonesia. This pandemic has an impact on sectors in Indonesia, one of which is the impact on education. With this pandemic, the government has implemented online learning until finally the government has implemented hybrid learning. This study's purpose is to determine whether this hybrid learning is effective in grade 12 students. Data collection was carried out in distributing questionnaires, interviewing grade 12 students and making direct observations to several schools. The results of our analysis show that hybrid learning for grade 12 students is considered less effective because students experience several changes in learning outcomes, understanding of the material and lack of communication between teachers and friends. However, because this research is still early, we will use the results of this study as the basis for further research where we will discuss the tools or products that are assembled regarding user needs in solving problems that occur in hybrid learning. Keywords - Education, Hybrid, Pandemic, Student.
EXPLORING THE ELEMENTS OF BRICOLAGE AS CREATIVE PRODUCT
Authors: Karabıyık Özkesek Emel , KETIZMEN GOKCE 
Published: March 2024

Product, a critical component of creativity, was explored within a creative setting by concentrating on bricolage as deemed implicit components of creativity. This study's major objective is to represent elements of bricolage as product creativity in a design studio. This study's primary objective is not to increase the efficacy of product creativity, but rather to accurately make a new description of the elements of product creativity based on the notions of bricolage. An experiment was performed with 25 student works designed as the part of the assignment titled `inform/perfom` in basic design studio. Rating scales were utilized as evaluation instruments.Considering the product creativity as bricolage, it was found that there is statistically significant relation between design elements, design principles and material utilization. Moreover, compared to design principles, design elements have a higher ratio of creative level in student works.
SSA2py: A High-Performance Python Implementation of the Source-Scanning Algorithm for Spatiotemporal Seismic Source Imaging
Authors: Fountoulakis Ioannis , Evangelidis Christos P. 
Published: March 2024

Abstract
This article introduces the first version of SSA2py (v.1.0)—an open-source package designed to implement the source-scanning algorithm (SSA). SSA2py is a Python-based, high-performance-oriented package that incorporates the SSA method, which has been effectively applied to numerous earthquakes for imaging the spatiotemporal behavior of the seismic source. The software supports a wide range of data and metadata resources. These include the International Federation of Digital Seismograph Networks Web Services, the SeedLink protocol, and others, ensuring optimal access to waveforms and station metadata. Furthermore, the code may evaluate the quality of accessible waveforms using signal analysis methods, allowing for the most appropriate data selection. The SSA method has been computationally optimized using multiprocessing techniques for efficient central processing unit and graphic processing units executions, enabling considerably accelerated computational processes even for large-scale grid searches. The program is also designed to provide statistical and methodological uncertainties for the executed cases through jackknife, bootstrap, and backprojection array response function tests. After appropriate tuning by the user, SSA2py can be used for detailed earthquake source studies that backprojection technique typically serves as a complementary output to the source inversion result or as a near-real-time tool for successful and quick identification of the style and complexity of the earthquake rupture. With a wide and flexible configuration, the user has complete control over all calculating aspects of SSA2py. This article provides a detailed description of the structure and capabilities of this new package, and its reliability is demonstrated through targeted applications to the 2004 Mw 6.0 Parkfield and 2019 Mw 7.1 Ridgecrest earthquakes. Furthermore, the computational efficiency of SSA2py is validated through rigorous performance tests.
PENGEMBANGAN THERMOBALANCE DIGITAL BERBASIS TEKNOLOGI SENSOR DAN LEMBAR KERJA PESERTA DIDIK (LKPD) UNTUK PEMBELAJARAN MATERI SUHU DAN KALOR
Authors: Yulkifli Yulkifli , Usmeldi Usmeldi , Yohandri Yohandri , Anggraini Anggraini 
Published: March 2024

An understanding of temperature and heat concept is one of the learning objectives in the 2013 Curriculum and the complexity of these concepts requires learning tools that can help students in achieving this objective. In this article, we discussed the development of digital thermobalance and student worksheets (LKPD) as supporting tools for learning temperature and heat concepts. The evaluation results showed that digital thermobalance and LKPD developed in this study have proven to be valid, practical, and effective. Findings from this evaluation showed the potential of digital thermobalance and LKPD as a learning media for temperature and heat subject. ABSTRAKPemahaman tentang konsep materi dan suhu adalah salah satu tujuan pembelajaran dalam Kurikulum 2013 dan kompleksitas materi ini menuntut adanya perangkat pembelajaran yang dapat membantu peserta didik dalam mencapai tujuan tersebut. Dalam artikel ini, kami akan memaparkan pengembangan thermobalance digital dan Lembar Kerja Peserta Didik (LKPD) sebagai penunjang pembelajaran suhu dan kalor. Hasil evaluasi menunjukkan bahwa thermobalance digital dan LKPD yang dikembangkan dalam penelitian ini telah terbukti valid, praktis, dan efektif. Temuan hasil evaluasi tersebut menunjukkan potensi thermobalance digital dan LKPD sebagai media pembelajaran materi suhu dan kalor.
Preparation of Biopesticide Powder from Jicama (Pachyrhizus erosus) Leaf Extract to Eradicate Whitefly Pests (Bemisia tabaci G.) on Eggplant Plants (Solanum melongena L.)
Authors: Fatmawati Laila Silvy , Andini Natasya Dian , Margono Dr. 
Published: March 2024

The use of synthetic pesticides in Indonesia is increasingly widespread because they are considered effective in killing pests. However, synthetic pesticides leave residues that can cause environmental pollution and human health problems. Therefore, another alternative is needed, namely switching to using environmentally friendly vegetable pesticides. One of the alternatives is biopesticide powder from jicama leaf extract as a whitefly pest controller. Pomace leaves contain active compounds that are toxic to whitefly, namely rotenone which is a group of flavonoid compounds. The method of making this biopesticide powder consists of 2 stages, the first is the preparation of jicama leaf extract through a maceration process for 2 days with the ratio of leaf powder and solvent, namely 40 g, 60 g, 80, and 100 g of jicama leaf powder in 500 ml of 96% ethanol. The second stage is the processing of jicama leaf extract into biopesticide powder through the encapsulation process, namely mixing the extract with maltodextrin using a weight ratio of extract maltodextrin, namely 1 : 2 (w : w). The analysis carried out was the test of biopesticide effectiveness against whitefly. After testing, it was found that the biopesticide powder that was effective in eradicating whitefly pests was a biopesticide powder with a ratio of 100 grams of jicama leaf powder in 500 mL of 96% ethanol with a dissolution dose of 20 g/L in water, which was able to kill whitefly with a mortality percentage of 100% on day 3.
Amygdala-liver signaling orchestrates rapid glycemic responses to stress and drives stress-induced metabolic dysfunction
Authors: Stanley Sarah , Devarakonda Kavya , O'Connor Richard , Jimenez-Gonzalez Maria , Alvarsson Alexandra , Hampton Rollie , Espinoza Diego , Li Rosemary , Shtekler Abigail , Conner Kaetlyn , Bayne Mitchell , Garibay Darline , Martin Jessie , Lehmann Vanessa , Wang Liheng , Kenny Paul 
Published: March 2024

Abstract
Behavioral adaptations to environmental threats are crucial for survival and necessitate rapid deployment of energy reserves. The amygdala coordinates behavioral adaptations to threats, but little is known about its involvement in underpinning metabolic adaptations. Here, we show that acute stress activates medial amygdala (MeA) neurons that innervate the ventromedial hypothalamus (MeAVMH neurons), which precipitates hyperglycemia and hypophagia. The glycemic actions of MeAVMH neurons occur independent of adrenal or pancreatic glucoregulatory hormones. Instead, using whole-body virus tracing, we identify a polysynaptic connection from MeA to the liver, which promotes the rapid synthesis of glucose by hepatic gluconeogenesis. Repeated stress exposure disrupts MeA control of blood glucose and appetite, resulting in diabetes-like dysregulation of glucose homeostasis and weight gain. Our findings reveal a novel amygdala-liver axis that regulates rapid glycemic adaptations to stress and links recurrent stress to metabolic dysfunction.
Targeting ERBB3 and AKT to overcome adaptive resistance in EML4-ALK non-small cell lung cancer
Authors: Bayliss Richard , Sampson Josephina , Ju Hyun-min , Yeoh Sharon , Choi Jene 
Published: March 2024

Abstract

The fusion event between EML4 and ALK drives a significant oncogenic activity in 5% of non-small cell lung cancer (NSCLC). Even though potent ALK-tyrosine kinase inhibitors (ALK-TKIs) are successfully used for the treatment of EML4-ALK-positive NSCLC patients, a subset of those patients eventually acquire resistance during their therapy. Here, we investigate the kinase responses in EML4-ALK V1 and V3 NSCLC cancer cells after acute inhibition with ALK TKI, lorlatinib. Using phosphopeptide chip array and upstream kinase prediction analysis, we identified a group of phosphorylated tyrosine peptides including ERBB and AKT proteins that are upregulated upon ALK-TKI treatment in EML4-ALK-positive NSCLC cell lines. Dual inhibition of ALK and ERBB receptors or AKT1 disrupts RAS/MAPK and AKT/PI3K signalling pathways, and enhances apoptosis in EML4-ALK NSCLC cancer cells. Heregulin, an ERBB3 ligand, differentially modulates the sensitivity of EML4-ALK cell lines to ALK inhibitors. These findings emphasize the important roles of AKT1 and ERBB3 to regulate signalling after acute lorlatinib treatment, identifying them as potential targets that may be beneficial to prevent adaptive resistance to EML4-ALK-targeted therapies in NSCLC.
Evaluation of Dragon’s Head Iranian landraces for resistance to prevalent diseases in the field and glasshouse conditions
Authors: Pouralibaba Hamid Reza , Kheirgoo Ma’asoumeh , Kia Shahriar 
Published: March 2024

Abstract

Dragon’s head (Lallemantia iberica) as an oilseed crop has been recently introduced to Iranian farmers and because of its tolerance to abiotic stresses has been acknowledged to be grown in drylands and rain-fed areas of the country in rotation with cereals and pulses. In this study, fifty Iranian L. iberica landrace were evaluated for the prevalent diseases under field conditions during 2019-2021 in Gonbad-Kavous, North of Iran. A spot lesion/blight symptom was observed in the field and the subsequent classical and molecular mycological studies identified Alternaria tenuissimaand A.atra as the causal agents. Subsequently, a complimentary experiment was conducted to screen genotypes for these disease agents under controlled conditions using the proposed scoring system invented in this study. Results showed a significant and negative strong correlation between Sclerotinia stem rot (SSR) with yield and plant height, while no relationship was observed between Alternaria spot/blight and agronomic traits. Nine and thirteen genotypes were identified as resistant and moderately resistant to SSR in the field and three of them showed additional resistance to Altarnaria spp. in the glasshouse. The resistant/high-yield genotypes identified through this research can be considered as valuable sources to be released as new cultivars or exploited in breeding programs.
Insights from a community-based survey on factors Influencing Acceptance and Uptake of Paxlovid (nirmatrelvir and ritonavir) as a COVID-19 Antiviral Medication in Singapore
Authors: Soh Sheng En Alexius Matthias , Ong Wei Ling Brenda , Thein Tun-Linn , Griva Konstadina , Chen I-Cheng Mark 
Published: March 2024

Abstract

Introduction
Antiviral treatment can reduce the burden of COVID-19. But utilisation can be suboptimal, even in a setting like Singapore where it is fully subsidized for those with selected medical conditions and older adults (≥ 50 years). We hence investigated the factors affecting awareness, acceptance, and initiative to request Paxlovid.
Methods
We assessed the Paxlovid awareness, factors impacting its uptake in a survey conducted from August 2022 to September 2022 through the SOCRATES cohort. Multivariable logistic regression was used to investigate associations between sociodemographics, perceptions, and attitudes with the key study outcomes.
Results
Among respondents to the Paxlovid survey, 54% were aware of Paxlovid. On being provided essential details about Paxlovid, 75% reported they would likely be receptive to taking it if prescribed, and 38% indicated the initiative to request for it if it was not suggested by their doctors. Factors associated with being aware of Paxlovid include aged 40 years old and above, higher education, citing websites as an information source, greater trust in healthcare providers (aOR: 1.65, 95% CI 1.26–2.15) and government communications (aOR: 0.69, 95% CI 0.55–0.86), and higher perceived risk of COVID-19 infection (aOR: 1.25, 95% CI 1.10–1.42). Factors associated with acceptance to take Paxlovid include male gender, citing trust in healthcare providers (aOR: 1.49, 95% CI 1.11–1.99) and government communications (aOR: 1.38, 95% CI 1.09–1.76), and higher perceived severity of COVID-19 (aOR: 1.23, 95% CI 1.07–1.42). Factors associated with initiative to request Paxlovid include male gender, having pre-existing diabetes and higher perceived severity of COVID-19 (aOR: 1.24, 95% CI 1.09–1.40). The most common reasons for why respondents might not take Paxlovid were concerns about side effects (64%), concerns about costs (29%), and the perception that COVID-19 is a mild (25%).
Conclusion
The majority of our respondents would take Paxlovid if it was prescribed to them, but a much smaller proportion would have the initiative to request for this. Key factors that may influence uptake are COVID-19 threat perceptions, trust in healthcare and government, and perceptions of the drug’s side effects and cost.
Research participant perceptions of personal utility in disclosure of individual research results from genomic analysis
Authors: Bogaert Brenda , Crevier Marie-Josée , Cindy Roth , Jox Ralf , Barazzetti Gaia 
Published: March 2024

Abstract

This article elaborates research participant perspectives on the communication of individual research results from genomic analyses. While most analyses focus on how to communicate results from the perspectives of clinicians or researchers, there is insufficient data on user perspectives and how this information may be used, valued, and interpreted by patients and their families. The concept of personal utility, which considers factors related to quality of life, including on how information may impact the person’s future decisions, has been shown to be particularly relevant to understand research participant perspectives and to move beyond clinical and analytic utility factors such as mortality and morbidity. This article draws from qualitative research of research participants awaiting genomic results in the case of sudden cardiac death. Our results show perspectives of personal utility in communication of genomic results, including cognitive, behavioral, and affective outcomes. Cognitive outcomes include gain of information, improved knowledge of etiology and inheritance characteristics, and curiosity for what might be found. Behavioral outcomes include being able to anticipate life decisions, while affective outcomes include various coping strategies used. We will also discuss the value of knowing negative results and incidental findings from the research participant’s perspective. This contribution gives suggestions on best practices to guide genome analysis returns, including incorporating participant wishes on individualized communication at the consent stage; developing relational autonomy approaches; and engaging them throughout the research trajectory.
Single-cell transcriptomics in MI identify Slc25a4 as a new modulator of mitochondrial malfunction and apoptosis-associated cardiomyocyte subcluster
Authors: Zhou Ting , Pan Jing , Xu Kai , Yan Chenghui , Yuan Jing , Song Haixu , Han Yaling 
Published: March 2024

Abstract

Objective
Myocardial infarction (MI) is the leading cause of premature death. The death of cardiomyocytes (CMs) and the dysfunction of the remaining viable CMs are the main pathological factors contributing to heart failure (HF) following MI. This study aims to determine the transcriptional profile of CMs and investigate the heterogeneity among CMs under hypoxic conditions.
Method
Single-cell atlases of the heart in both the sham and MI groups were developed using single-cell data (GSE214611) downloaded from Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo/). The heterogeneity among CMs was explored through various analyses including enrichment, pseudo time, and intercellular communication analysis. The marker gene of C5 was identified using differential expression analysis (DEA). Real-time polymerase chain reaction (RT-PCR), bulk RNA-sequencing dataset analysis, western blotting, immunohistochemical and immunofluorescence staining, Mito-Tracker staining, TUNEL staining, and flow cytometry analysis were conducted to validate the impact of the marker gene on mitochondrial function and cell apoptosis of CMs under hypoxic conditions.
Result
We identified a cell subcluster named C5 that exhibited a close association with mitochondrial malfunction and cellular apoptosis characteristics, and identified Slc25a4 as a significant biomarker of C5. Furthermore, our findings indicated that the expression of Slc25a4 was increased in failing hearts, and the downregulation of Slc25a4 improved mitochondrial function and reduced cell apoptosis.
Conclusion
Our study significantly identified a distinct subcluster of CMs that exhibited strong associations with ventricular remodeling following MI. Slc25a4 served as the hub gene for C5, highlighting its significant potential as a novel therapeutic target for MI.