bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antidepressant drug‐induced stimulation of mouse hippocampal neurogenesis is age‐dependent and altered by early life stress
Authors: Navailles Sylvia , Hof Patrick R. , Schmauss Claudia 
Published: May 2008

AbstractThe continuous generation of new neurons in the adult hippocampus exhibits remarkable plasticity. Decreased neurogenesis is thought to underlie depression‐like behaviors, and increased neurogenesis is thought to occur following antidepressant drug treatment. Studies on different strains of mice, however, yielded contrasting results with regard to the link between behavioral modifications induced by antidepressant drugs or environmental enrichment and changes in adult hippocampal neurogenesis. Therefore, we conducted a comparative study on the inbred strains Balb/c and C57Bl/6 that differ substantially in emotionality, stress reactivity, and behavioral responses to chronic antidepressant drugs. Quantitative assessments of progenitor cell proliferation and immature neuronal differentiation in the dentate gyrus revealed that, despite significantly different basal proliferation rates between both strains, neither strain exhibited changes in adult neurogenesis after exposure to early life stress or adult chronic fluoxetine treatment. A stimulatory effect of fluoxetine on adult hippocampal neurogenesis was only detected when treatment was initiated during adolescence, and this effect was abolished in mice exposed to early life stress, a prominent risk factor for developing adult‐onset depression‐like behaviors. Thus, in both strains of mice neither adult fluoxetine treatment nor adolescent fluoxetine treatment following early life stress exposure increased the proliferation and early differentiation of adult neural progenitor cells. J. Comp. Neurol. 509:372–381, 2008. © 2008 Wiley‐Liss, Inc.
Dielectric and microhardness studies on L‐citrulline and L‐ascorbic acid admixture TGS crystals
Authors: Linet J. Mary , Priya S. Mary Navis , Dinakaran S. , Das S. Jerome 
Published: May 2008

AbstractSingle crystals of amino acid doped (L–citrulline, L‐ascorbic acid) triglycine sulphate were grown by slow evaporation technique. The lattice parameters and crystalline quality were confirmed by powder X‐ray diffraction studies. The presence of functional groups in the grown crystals was confirmed by Fourier transform infrared spectrum analysis. The dielectric studies were carried out to identify the phase transition temperature and the dielectric constant was found to be less for both the doped crystals than pure triglycine sulphate crystal. Micro hardness studies were carried out using Vickers pyramidal indentation technique at room temperature showed a decrease in hardness due to doping. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Controlled synthesis of selenium of different morphologies at room temperature
Authors: Ma Jianmin , Liu Xiaodi , Wu Yong , Peng Peng , Zheng Wenjun 
Published: May 2008

AbstractA facile and convenient chemical precipitation route has been developed for the controlled growth of selenium nanowires and hierarchical microspheres at room temperature, with Na2SeO3 and hydrazine hydrate as starting materials in the presence of 1,2,3‐trimethylimidazolium tetrafluoroborate (tmimBF4). The surface morphology of microspheres can be tuned by adjusting the reaction media. The products were characterized by X‐ray powder diffraction (XRD) and scanning electron microscope (SEM). Possible formation mechanisms of selenium nanowires and microspheres are proposed, respectively. The influences of the nature of reaction media, agitation and tmimBF4 on the morphologies development were experimentally investigated and it was found that these factors were of great importance for the formation of Se morphologies. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Synthesis, characterization and crystal structure of a 2D Cd(II) complex with a 4,4'‐diazenediyldiphthalic acid ligand
Authors: Lu Lu , Wang Jun , Bai Jian‐Wei , Hou Yang , Yang Bin , Zhao Bao‐Zhong 
Published: May 2008

AbstractAn exploration of the cadmium‐L system under hydrothermal condition, has led to the isolation of a novel framework {[Cd(L)0.5(H2O)3]}n (1) (H4L = 4,4'‐diazenediyldiphthalic acid). Single‐crystal X‐ray analysis reveals that it crystallizes in the triclinic space group P‐1. a = 5.746(3) Å, b =6.526(4) Å, c = 14.701(8) Å, α=92.348(8), β = 99.622(6), γ=106.877(7)°. The CdII ions are linked into an extended 2‐D rectangle‐like structure via L ligands, which exhibits an attractive three‐connected honeycomb topological network. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Calorimetric and phase equilibria studies of the Ni–Sn–Bi system
Authors: Vassilev G. P. , Lilova K. I. , Gachon J.‐C. 
Published: May 2008

AbstractThe phase equilibria at 1273 K were investigated and an isothermal section of the Ni‐Sn‐Bi phase diagram was constructed. The phase boundaries are inclined to the Bi‐rich region that is agreement with phase equilibria at lower temperatures. The molar enthalpies of formation of liquid ternary Ni–Sn–Bi alloys have been determined at 833, 873 and 933 K by direct reaction calorimetry using pellets of 325 mesh powders of pure Ni, Sn and Bi. Measurements were performed with alloys containing from 0.05 to 0.10 mole fractions of nickel, and at ratios of tin and bismuth mole fractions XSn/XBi = 2.8, 1.2 and 0.43. The experimental calorimetric data were used to calculate a regular solutions parameter of the ternary liquid phase by means of two different thermodynamic data files. It was found that the Ni–Sn–Bi ternary liquid phase could be described as temperature independent ternary regular solution. The assessed values of the ternary interaction parameter are ‐280 J·mol–1 and 56 000 J·mol–1, depending on the binary parameters used. Enthalpies of formation of solid binary phases were measured, too. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Atomistic simulation of the self‐diffusion in Mg (001) surface
Authors: Zhang Jian‐Min , Yu Hua‐Zhi , Xu Ke‐Wei 
Published: May 2008

AbstractBoth the formation energies and the intra‐ and inter‐layer diffuse activation energies of a vacancy in the first six lattice planes of Mg (001) surface have been calculated by combining the modified analytical embedded‐atom method (MAEAM) with molecular dynamics (MD). The results show that the effect of the surface on the formation and migration of the vacancy is only down to the third‐layer. It is easer for a single vacancy to form and to migrate in the first layer. Furthermore, the vacancy in the second layer is favorable to migrate to the first layer. This is in agreement with the experimental results that the first layer has the highest concentration of the vacancy. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A facile method to synthesize spherical PbS and their shape evolution process
Authors: Zhang Li , Yang Liangbao 
Published: May 2008

AbstractPbS microspheres have been synthesized in large scale by a hydrothermal route, in which tungstosilicate acid (TSA) is used. The obtained PbS microspheres have been characterized using X‐ray diffraction (XRD), transmission electron microscopy (TEM), Scanning electron microscopy (SEM) and X‐ray photoemission spectroscopy (XPS). Experiments show that Tungstosilicate acid plays an important role for the control of the morphology of PbS microstructures. An evolution process is described based on experimental facts. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Synthesis and characterization of doped lithium aluminate nanocrystalline particles by sol‐gel method
Authors: Raj C. Justin , Lincoln M. B. , Das S. Jerome 
Published: May 2008

AbstractNanocrystalline particles of Co2+doped lithium aluminate (Co2+:LAO) and Ni2+‐doped lithium aluminate (Ni2+:LAO) were synthesized by sol–gel method. The crystalline nature and particle size of the samples were characterized by X‐ray diffraction analysis (XRD). The morphology and the presence Co2+ and Ni2+ in the synthesized samples were analyzed by scanning electron microscope (SEM) and energy dispersive X‐ray analysis (EDAX). The presences of functional groups in the samples were analyzed using FT‐IR analysis. The optical absorbance of the synthesized samples were observed using UV absorption spectral analysis. The frequency dependent dielectric behaviour of the synthesized nano materials was analyzed. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Topology of Spin‐Crossover Polymers and Mutual Influence of Ligands
Authors: Le Guennic Boris , Matouzenko Galina S. , Borshch Serguei A. 
Published: May 2008

AbstractDensity functional quantum‐chemical calculations for mononuclear fragments, [FeII(pyim)2(bpy)]2+ [pyim = 2‐(2‐pyridyl)imidazole] and [FeII(aqin)2(bpy)]2+ (aqin = 8‐aminoquinoline), of two recently synthesized spin‐crossover compounds forming zigzag and linear coordination polymers, respectively, have been performed. The calculations suggest that the overall structure of the polymers is defined by the preference of the bidentate ligands for the cis or trans coordination mode, which in turn is determined by the character and efficiency of metal–ligand π‐interactions. This hypothesis is used to predict the structures of two other spin‐transition compounds, which have not been studied by X‐ray crystallography.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Application of a Power Time Current to the Study of a Catalytic Mechanism in Chronopotentiometry and Reciprocal Derivative Chronopotentiometry. Advantages of a Cyclic Stationary Response
Authors: Molina Ángela , López‐Tenés Manuela , Soto Carmen M. 
Published: May 2008

AbstractThis paper develops the theory for a pseudo‐first order catalytic mechanism in chronopotentiometry with a power time current, I(t)=I0tu (u≥−1/2), applied to a spherical electrode of any size, and the advantages of the use of small electrodes and ultramicroelectrodes are discussed. The advantages of using a cyclic power time current to reach a stationary response suitable for characterizing a catalytic mechanism easily and accurately are reported. The reciprocal derivative (dt/dE−E) curves, which present peaks quantitatively related to the kinetic parameters of the chemical reaction, have been obtained from the potential‐time responses. The influence of the homogeneous kinetic, the electrode radius and the power of time current in the achievement of a stationary response is analyzed. Methods for determining thermodynamic and kinetic parameters of the chemical reaction are proposed.
Implementation of a protein profiling platform developed as an academic‐pharmaceutical industry collaborative effort
Authors: Végvári Ákos , Magnusson Mattias , Wallman Lars , Ekström Simon , Bolmsjö Gunnar , Nilsson Johan , Miliotis Tasso , Östling Jörgen , Kjellström Sven , Ottervald Jan , Franzén Bo , Hultberg Hans , Marko‐Varga György , Laurell Thomas 
Published: May 2008

AbstractAs much attention has devoted to the proteome research during the last few years, biomarker discovery has become an increasingly hot area, potentially enabling the development of new assays for diagnosis and prognosis of severe diseases. This is the field of research interest where efforts originating from both academic and industrial groups should jointly work on solutions. In this paper, we would like to demonstrate the fruitful combination of both research domains where the scientific crossroads sprout fresh ideas from the basic research domain and how these are refined and tethered to industrial standards. We will present an approach that is based on novel microfluidic devices, utilizing their benefits in processing small‐volume samples. Our biomarker discovery strategy, built around this platform, involves optimized samples processing (based on SPE and sample enrichment) and fast MALDI‐MS readout. The identification of novel biomarkers at low‐abundance level has been achieved by the utilization of a miniaturized sample handling platform, which offers clean‐up and enrichment of proteins in one step. Complete automation has been realized in the form of a unique robotic instrumentation that is able to extract and transfer 96 samples onto standard MALDI target plates with high throughput. The developed platform was operated with a 60 sample turnaround per hour allowing sensitivities in femtomol regions of medium‐ and low‐abundant target proteins from clinical studies on samples of multiple sclerosis and gastroesophageal reflux disease. Several proteins have been identified as new biomarkers from cerebrospinal fluid and esophagus epithelial cells.
Glycosylation analysis of glycoproteins and proteoglycans using capillary electrophoresis‐mass spectrometry strategies
Authors: Amon Sabine , Zamfir Alina D. , Rizzi Andreas 
Published: May 2008

AbstractThis review highlights recent developments in glycosylation analysis by modern MS in combination with CE based preseparation. Focused on CE‐MS strategies aimed for glycotyping, the review addresses the detailed glycoform analysis of glycoproteins, glycopeptides, and proteoglycans. Glycoform analysis in the context of modern glycoproteomics is briefly addressed, as well. CZE, CIEF, and frontal analysis CE approaches hyphenated to high‐resolution multistage MS for the detailed analysis of protein‐linked glycan structures are overviewed in a comprehensive way. Advantages and limitations of various methodological approaches and techniques as well as mass spectrometric instrumentation are discussed in the particular context of glycoanalysis.
Free and bound volatiles of rocket (Eruca sativa Mill.)
Authors: Blažević Ivica , Mastelić Josip 
Published: May 2008

AbstractVolatile fractions of rocket (Eruca sativa Mill.) flowers and leaves with green beans were isolated by hydrodistillation in a Clevenger apparatus from fresh plant material prior to and after autolysis and from dried plant material. All isolates of volatile compounds were analysed by gas chromatography/gas chromatography–mass spectrometry (GC/GC–MS). Sulphur and/or nitrogen compounds, fatty acids and esters, aliphatic alcohols and carbonyl compounds and some other compounds in smaller percentages were identified. The main sulphur and/or nitrogen components were glucoerucin degradation volatiles: 4‐methylthiobutyl isothiocyanate (9.0–81.7%) and 5‐methylthiopentanenitrile (2.4–17.7%). Also, fatty acids and esters were identified as major components, such as: decanoic acid (1.2–32.8%), hexadecanoic acid (2.7–22.3%), dodecanoic acid (0.6–8.7%), (E,E)‐9,12‐octadecadienoic acid (6.5%), tetradecanoic acid (1.5–6.4%), methyl linolenate (0.4–5.1%) and methyl hexadecanoate (0.3–1.2%). The O‐glycosides of volatile compounds were isolated from fresh plant material of rocket flowers and leaves with green beans. After the enzymatic hydrolysis of glycosides and analysis by GC and GC–MS, 27 volatile aglycones were identified for the first time. The main aglycones were: 2‐phenylethyl alcohol (23.4–62.8%), methyl vanillate (5.4–12.4%), benzyl alcohol (5.4–8.6%), eugenol (1.2–7.5%), p‐anisyl alcohol (0.4–4.6%), 3‐oxo‐α‐ionol (0.4–3.2%), 4‐oxo‐β‐ionol (3.2%), o‐methoxy phenol (1.1–2.8%), phenol (0.3–2.8%) and trans‐carveol (0.2–2.3%). When compared, only (Z)‐3‐hexen‐1‐ol, 2‐methylbutanoic acid and 2‐phenylacetaldehyde were present in volatiles obtained by hydrodistillation and the volatile O‐aglycone fractions. Copyright © 2008 John Wiley & Sons, Ltd.
Human resources as a strategic partner: Sitting at the table with Six Sigma
Authors: Fazzari Alan J. , Levitt Kenneth 
Published: May 2008

AbstractFor nearly three decades, the quality management philosophy known as Six Sigma has brought competitive advantage to organizations implementing it. The typical approach, however, has been to have leaders from operations, engineering, quality, and marketing manage this strategic initiative. Human resource's role has been to default to the administrative tasks of organizing the required training, keeping records, and assisting in the selection of candidates for the program. Yet for the past two decades human resources has also been struggling to gain a seat at the executive table. This paper gives an overview of Six Sigma and shares insights on how human resources is a natural fit to lead a breakthrough change initiative as strategically focused as Six Sigma in small and midsize organizations. By so doing, HR can be assured value‐added status.
SEM analysis of enamel surface treated by Er:YAG laser: Influence of irradiation distance
Authors: Souza‐Gabriel A.E. , Chinelatti M.A. , Borsatto M.C. , Pécora J.D. , Palma‐Dibb R.G. , Corona S.A.M. 
Published: May 2008

AbstractBackground:Depending on the distance of laser tip to dental surface a specific morphological pattern should be expected. However, there have been limited reports that correlate the Er:YAG irradiation distance with dental morphology.Purpose:To assess the influence of Er:YAG laser irradiation distance on enamel morphology, by means of scanning electron microscopy (SEM).Methods:Sixty human third molars were employed to obtain discs (≅1 mm thick) that were randomly assigned to six groups (n = 10). Five groups received Er:YAG laser irradiation (80 mJ/2 Hz) for 20 s, according to the irradiation distance: 11, 12, 14, 16, or 17 mm and the control group was treated with 37% phosphoric acid for 15 s. The laser‐irradiated discs were bisected. One hemi‐disc was separated for superficial analysis without subsequent acid etching, and the other one, received the phosphoric acid for 15 s. Samples were prepared for SEM.Results:Laser irradiation at 11 and 12 mm provided an evident ablation of enamel, with evident fissures and some fused areas. At 14, 16 and 17 mm the superficial topography was flatter than in the other distances. The subsequent acid etching on the lased‐surface partially removed the disorganized tissue.Conclusions:Er:YAG laser in defocused mode promoted slight morphological alterations and seems more suitable for enamel conditioning than focused irradiation. The application of phosphoric acid on lased‐enamel surface, regardless of the irradiation distance, decreased the superficial irregularities. Microsc. Res. Tech., 2008. © 2008 Wiley‐Liss, Inc.
Shannon's entropy and fractal dimension provide an objective account of bone tissue organization during calvarial bone regeneration
Authors: Rocha Lenaldo B. , Adam Randall L. , Leite Neucimar J. , Metze Konradin , Rossi Marcos A. 
Published: May 2008

AbstractThe regeneration of compact bone involves the deposition of a poorly organized connective tissue template that remodels into compact lamellar bone. An objective description of this process is difficult because classical histomorphometry is unable to correctly characterize qualitative changes in tissue complexity. In this study, we demonstrated the use of two distinct methods of image texture analysis, the Shannon's entropy [standard error (SE)], and the fractal dimension (FD) to characterize the formation and remodeling of newly formed compact bone within two different polyanionic collagen‐elastin matrices. The matrices were implanted in defects created into parietal bones of rats. The SE and FD were calculated for histological images of the experimental groups collected 3, 7, 15, 30, 60, and 365 days postsurgery and for the original bone only at day 365. Results showed that the SE and the FD initially increased and then diminished for all groups from day 3 to day 365 approaching the values of the original bone. These results are consistent with poor tissue organization during early osteogenesis that remodels into an organized lamellar structure, showing that these methods can be valuable tools to describe bone tissue remodeling during the regeneration process of compact bones. Microsc. Res. Tech., 2008. © 2008 Wiley‐Liss, Inc.
Preparation of a sorbitol methacrylate grafted silica as stationary phase for hydrophilic interaction chromatography
Authors: Persson Jonas , Hemström Petrus , Irgum Knut 
Published: May 2008

AbstractA new highly hydrophilic stationary phase based on graft polymerization of sorbitol methacrylate from the surface of Kromasil silica particles is described. Polymerization was initiated by thermal cleavage of tert‐butyl hydroperoxide covalently attached to the silica particle surface. Due to the highly amphiphilic properties of the monomer, an extensive search was needed to find solvent conditions that enabled surface‐initiated polymerization. This was finally solved by using a mixture of solvents that only partially dissolved the monomer. The graft polymerization was confirmed by Fourier transform infrared spectroscopy and elemental analysis. The resulting stationary phase was evaluated by HPLC and exhibited a selectivity markedly different from that of commercially available columns and of neat silica.
Effect of external cueing on gait in Huntington's disease
Authors: Delval Arnaud , Krystkowiak Pierre , Delliaux Marie , Blatt Jean‐Louis , Derambure Philippe , Destée Alain , Defebvre Luc 
Published: May 2008

AbstractIn Huntington's disease (HD) patients, gait is characterized by a timing disorder with marked intraindividual variability in temporal gait parameters (caused by the presence of both hyperkinetic and hypokinetic features). We sought to determine the influence of use of a metronome on gait parameters in patients simultaneously performing motor or cognitive tasks that required attentional resources. The objective is to evaluate the influence of rhythmic cues on gait interference during self‐regulated walking and a dual task paradigm in HD. Fifteen HD patients and 15 paired controls were asked to walk and simultaneously perform another motor task (carrying a tray with four full glasses) or a cognitive task (counting backwards). We evaluated the effect of a metronome (set at 100% and 120% of the subject's self‐determined cadence) in three different task conditions (gait alone, gait + motor task, gait + cognitive task). The use of auditory cues during free gait and dual tasks did not improve kinematic parameters in HD patients, in contrast to the situation for control subjects (improvement in gait speed and cadence but not stride length when the metronome was set at 120% in all conditions). HD patients have difficulty in synchronizing their footsteps with a metronome, mainly due to attentional deficits. © 2008 Movement Disorder Society
Evaluating Parkinson's disease patients at home: Utility of self‐videotaping for objective motor, dyskinesia, and ON–OFF assessments
Authors: Goetz Christopher G. , Leurgans Sue , Hinson Vanessa K. , Blasucci Lucia M. , Zimmerman Jennifer , Fan Wenqing , Nguyen Tiffany , Hsu Ann 
Published: May 2008

AbstractThe objective is to test feasibility and utility of home‐based videos for assessing Parkinson's disease (PD) patients. As part of a clinical trial, patients opted between coming to the study sites or learning to videotape assessments at home. Those opting for at‐home filming completed training on videotape techniques. Ten‐minute films were taken at 30‐minute intervals over 8.5 hours, 2 and 4 weeks after study entry using a protocol covering most items of the UDPRS motor examination and all Rush Dyskinesia Rating Scale items. After each filming, patients marked their ON/OFF status, based on prior training. We determined the number of patients who elected self‐taping and the quality of video segments obtained. To assess ON/OFF patient accuracy, we compared the rater's and patient's assessment of ON/OFF at each time point. Of 12 participants, 10 elected self‐videotaping and only 1 time point was missed (99.5% taping compliance). All self‐recorded video segments were clear with all protocol elements included. With the exception of one missed ON/OFF rating, patient‐based self‐ratings occurred on time. Rating ON/OFF, UPDRS, and RDRS assessments for 8.5 hours required 170 minutes by the blinded rater. In spite of patient training, mean ON/OFF concordance between rater and patients was only 64%. At home video‐based self‐recordings are feasible and allow accurate rater‐based ON/OFF assessments. In this group of patients with no or mild fluctuations, in spite of pretrial training, patients were inaccurate in separating ON vs. OFF status. © 2008 Movement Disorder Society