bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tinggalan Tradisi Megalitik Situs Watugong, Kelurahan Tlogomas, Kecamatan Lowokwaru, Kota Malang: Kajian Bentuk, Fungsi, dan Makna
Authors: Alghifari Nabil Naufal , Bawono Rochtri Agung , Setiawan I Ketut 
Published: March 2024

There are remnants of late prehistoric life in the Greater Malang, one of which is located in the Metro watershed, which stretches from Malang City's west to south. The area was once inhabited during the Megalithic period, as evidenced by the remains of the megalithic tradition along the Metro watershed, which was considered a holy river for its rich natural resources. Watugong Village is a human settlement area that supported the megalithic tradition because it has a cultural heritage site from the end of the Neolithic era to the arrival of the Hindu-Buddha period. This research aims to determine the form, function, and meaning of the megalithic tradition remains found at Watugong Site. Researchers used descriptive-morphological analysis, accompanied by an analysis of contextual relationships between the megalithic remains on the site and the surrounding environment and findings, then did comparative analysis to compare research object data with other similar research objects, and ethnoarchaeological analysis to find out the meaning of the continuous rituals to preserve the beliefs of their ancestors that are still carried out by the local community. The results obtained were that the archaeological remains at Watugong Site are of a megalithic pattern with a cross-time context at the same time as the Hindu-Buddhist influence began to enter the Watugong Village area, and the tradition of honoring ancestors derived from the megalithic tradition is still carried out today by the local community.
Medidas de prevención de infección de vías urinarias en pacientes con sonda vesical
Authors: Toapanta-Yanzapanta Erika Vanessa , Salgado- Oviedo Gabriela Socorro 
Published: March 2024

Introducción: Las infecciones del tracto urinario (ITU) relacionadas con el uso de catéter urinario constituyen una problemática significativa en el ámbito de la atención sanitaria. Estas infecciones constituyen uno de los principales motivos de morbilidad entre los pacientes internados, conllevando una prolongación de la duración de la estadía hospitalaria, costos de tratamiento y riesgo de resistencia a los antibióticos.
Objetivo: El propósito de este artículo de investigación es revisar y consolidar las intervenciones para reducir la prevalencia de infecciones del tracto urinario asociadas al uso de catéteres vesicales
Metodología: Se ejecutó una revisión bibliográfica exhaustiva en plataformas digitales como PubMed, Medline y Google Scholar, utilizando palabras clave como "prevención de ITU", "sonda vesical" y "control de infecciones". Se seleccionaron estudios publicados en los últimos 6 años, dando prioridad a revisiones sistemáticas, metaanálisis y estudios clínicos controlados.
Resultados: Indican que el método aséptico durante la inserción y el mantenimiento de sondas, junto con la educación continua del personal sanitario, disminuyen significativamente la incidencia. La selección adecuada de la sonda, su cuidado, y la revisión periódica de la necesidad de su permanencia, son también factores cruciales.
Conclusiones: La implementación de protocolos de inserción y mantenimiento aséptico, junto con la formación del personal y la revisión constante de la necesidad de la sonda, son medidas efectivas para prevenir. La educación del paciente y la monitorización para una pronta intervención ante signos de infección son igualmente importantes. Estas estrategias integradas son fundamentales para optimizar la calidad de la atención al paciente y disminuir las infecciones vinculadas.
OPÇÕES MEDICAMENTOSAS NO TRATAMENTO DA LEISHMANIOSE TEGUMENTAR AMERICANA CUTÂNEA
Authors: Miranda Carolina Galgane Lage , Cardoso Jean Matheus Guedes , Alcântara Lucas Oliveira Nepomuceno de , Santos Leandra de Cássia Ribeiro dos , Dutra Ana Luisa Valcanaia , Carvalho Filipe Oliveira Ferrolho de , Rocha Lucas de Almeida , Guedes Ana Beatriz Gonçalves de Sousa , Aniszewski Rayssa Victoria Lima , Soares Paulo Augusto Borges , Felipe Ana Luísa Gonçalves 
Published: March 2024

A Leishmaniose Tegumentar Americana é uma doença infecciosa endêmica em cerca de 100 países, com três formas predominantes: a cutânea, a mucosa e a visceral. É classicamente, transmitida pela picada do mosquito Lutzomyia e cursa, após a infecção, com a formação de lesão papulosa, a qual evolui para formação de nódulo, podendo até estar associada com adenopatia regional. A Leishmaniose Cutânea (LC), merece atenção especial pois é a apresentação mais recorrente de LTA, subdividida em duas formas: localizada e disseminada. O diagnóstico da LTA compreende a associação da história clínica com o perfil epidemiológico local, associado com exames laboratoriais que comprovem a presença de Leishmania. Os exames complementares de escolha são: o histopatológico, que revela a presença do amastigota em tecido; o isolamento do parasita em meio de cultura in vitro e a detecção de DNA do parasita por meio de exame de Reação em Cadeia de Polimerase (PCR). Quanto ao tratamento dessa patologia, foco principal deste trabalho, existem drogas em desenvolvimento e outros fármacos de uso já consagrado, a citar: antimoniais pentavalentes, a anfotericina B lipossomal ou desoxicolato, além da pentamidina, que pertence às diaminas aromáticas e é utilizada para tratamento em regiões do continente americano, asiático e africano. Visto isso, ao considerar o impacto que a LTA pode provocar na qualidade de vida humana, entende-se a necessidade de elencar os principais medicamentos utilizados no seu tratamento, com o intuito de compará-los e enumerar as opções mais eficazes e seguras. Portanto, foi realizada uma revisão sistemática de literatura, em que se foram avaliadas, detalhadamente, pesquisas e trabalhos científicos publicados nos últimos 10 anos (janeiro de 2014 - janeiro de 2024), nas bases de dados bibliográficos PubMed e na Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS). Assim, será possível analisar quais as opções terapêuticas disponíveis no mercado, além de citar os novos medicamentos em desenvolvimento, sobretudo com o intuito de minimizar os efeitos colaterais das drogas em uso.
Inteligencia artificial y docentes
Authors: Almaraz Rodríguez Omar David 
Published: March 2024

Se realizo? un ana?lisis bibliome?trico con 897 arti?culos de investigacio?n sobre inteligencia artificial y docentes, utilizando los resultados emanados del metabuscador Dimensions. El conjunto de datos obtenidos se analizo? con Bibliometrix y con Vosviewer, con el objetivo de proporcionar informacio?n sobre las tendencias de investigacio?n sobre la inteligencia artificial y los docentes. Como principales resultados se obtuvo que la investigacio?n en esta a?rea del conocimiento va desde 1978 hasta 2023. Se identificaron tendencias clave, como el notable aumento de investigaciones a partir de 2018 y la predominancia de publicaciones en revistas como Education and Information Technologies, Sustainability, e International Journal of Emerging Technologies in Learning. A nivel geogra?fico, China lidera la investigacio?n en este a?mbito, seguida por Estados Unidos y Espan?a. A pesar de la vasta produccio?n, existen brechas geogra?ficas evidentes en pai?ses como Me?xico, mostrando una participacio?n limitada. Los autores ma?s destacados en este campo provienen predominantemente de Asia, con Chai Ching Sing y Thomas Chiu siendo figuras centrales en la discusio?n. A trave?s de un ana?lisis de coautori?a y citacio?n, se identificaron obras seminales que han influenciado las direcciones actuales de investigacio?n. En conclusio?n, este estudio ofrece una panora?mica amplia y detallada de la relacio?n entre la inteligencia artificial y docentes, subrayando a?reas de intere?s y oportunidades futuras para investigadores y educadores.
Aprendizaje neuroemocional, pensamiento complejo y transdisciplinariedad Versus bajo dominio de la lectura en 5º grado
Authors: Jiménez Deferia Bladimir 
Published: March 2024

La presente investigación en educación indígena sobre el bajo dominio de la lectura, en quinto grado en primaria bilingüe intercultural multigrado, presenta algunas recomendaciones experimentales, metodológicas científicas basados en las ciencias neurales ,emocionales, pedagógicas y aportes en lecturas, aplicables para todos los niveles, en los diversos contextos sociales culturales o políticos, que coadyuban al profesorado a entender y ayudar a los alumnos con esta problemática, sin etiquetarlos ni segregarlos con una intervención que lesione la integridad, la inclusión y el derecho a la educación del educando. Una propuesta con visión desde el pensamiento complejo, holística y transdisciplinar de enseñanza principalmente por proyectos, resultados, de la experiencia de casi tres décadas como docente frente a grupo en el ámbito educativo.
Stabilisasi Pemanfaatan Garam Dapur (NaCl) Dan Serbuk Kaca (SiO2) Terhadap Kuat Geser Dan Kuat Tekan Bebas Tanah Lempung
Authors: Kalua Gustianus , Lebang Fauzy , Yuniarto Eka 
Published: March 2024

Tanah merupakan permukaan dasar yang utama bagi semua pekerjaan konstruksi. Tetapi tidak semua jenis tanah dapat digunakan sebagai bahan konstruksi. Apabila tanah tersebut tidak memenuhi persyaratan, maka tanah tersebut perlu distabilisasi.
Dalam penelitian ini digunakan bahan Garam Dapur (NaCl) dan Serbuk Kaca (SiO2) yang lolos saringan 200 sebagai bahan perbaikan tanah lempung. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan garam dapur (NaCl) terhadap kuat geser dan kuat tekan bebas pada tanah lempung yang dicampur dengan pecahan limbah serbuk kaca (SiO2) dengan kadar tertentu yaitu 0%, 3%, 9%, 15% pada pengujian kuat geser yang dilakukan dengan penambahan garam dapur 10% ditambah serbuk kaca 0%, 3%, 9%, dan 15% diperoleh nilai cohesi 0,5170, 0,6971, 0,4123, dan 0,3373, sedangkan nilai sudut geser diperoleh nilai 27,34, 34,88, 22,41, 18,64, adapun nilai kuat geser diperoleh nilai 1,5079, 2,0332, 1,2025, dann 0,9838.sedangkan pada pengujian kuat tekan diperoleh nilai qiu rata 0,324, 0,378, 0,268, dan 0,253.
Peninjauan Faktor Keamanan Penanganan Longsoran Ruas Jalan Batas Kota Maros – Batas Kabupaten Bone Dengan Metode Fellenius dan Plaxis
Authors: Herlambang Andy , Lebang Fauzy , Setiawan Arman 
Published: March 2024

Avalanche handling on the bts road section. Maros City – bts. Kab. Bone needs to review the value of the safe factor of the handling method applied. This study aims to quantitatively examine the influence of geotextiles and retaining walls on the magnitude of the value of the safe factor on a slope. This analysis uses data from the results of avalanche handling work on KM.89+995-90+045 and KM.90+395-90+405. In this study, 2 methods were used, namely the Fellenius method and the Plaxis program method. The results of this study show that the amount of safe factor values from the handling methods used at KM.89+995-90+045 and KM.90+395-90+405 locations is 2.71 and 2.27 obtained from the results of data processing using the Plaxis program, while using the Fellenius method the safe factor values are 2.70 and 1.66. Thus each safe factor value obtained is greater than the established safe factor value ( Fs > 1.5).
PENGARUH PEMERIKSAAN PAJAK, SISTEM E-FILING DAN KEPATUHAN WAJIB PAJAK TERHADAP PENERIMAAN PAJAK (Studi Kasus pada KPP Pratama Jakarta Cengkareng Tahun 2023)
Authors: Waruwu Indani , Sarpinggah Siti 
Published: March 2024

PENGARUH PEMERIKSAAN PAJAK, SISTEM E-FILING DAN KEPATUHAN WAJIB PAJAK TERHADAP PENERIMAAN PAJAK
(Studi Kasus pada KPP Pratama Jakarta Cengkareng Tahun 2023)
Pengaruh Pendidikan Kesehatan Berbasis Digital terhadap Kualitas Hidup pada Ibu Pasca Salin 0-12 Bulan dengan Riwayat Menikah Dini
Authors: Felisha Achsan Alvina , Nurdiana Nurdiana , Nurisa Windari Era 
Published: March 2024

Pernikahan hendaknya di bangun dengan segala kesiapan yang matang seperti umur. Karena jika umur belum terpenuhi dari segi ekonomi mereka belum mapan dan mandiri dan dari segi psikologis ibu muda memiliki tingkat kecemasan yang tinggi. Hal ini juga dapat berpengaruh terhadap kualitas hidup dari pasangan ini. Mayoritas ibu pasca bersalin yang menikah diusia dini, tidak terpenuhi informasi tentang kesehatan reproduksi dan perawatan anak, sehingga ibu kurang bisa menjalankan perannya. Tujuan penelitian ini adalah untuk meningkatkan kualitas hidup (Quality of Life) dengan pendidikan kesehatan berbasis digital pada ibu pasca salin 0-12 bulan yang menikah dini di Kabupaten Probolinggo. Penelitian ini menggunakan metode atau desain Quasy experimental dengan rancangan pra-pasca tes dalam satu kelompok (one-group pre-post test design). Dengan menggunakan 34 Ibu Pasca salin di berbagai kecamatan Leces, Maron, Sukapura, Paiton Kabupaten Probolinggo. Informasi yang dibutuhkan pada penelitian ini dikumpulkan melalui wawancara kuesioner.Peneliti kemudian menggunakan metode wilcoxon untuk menganalisis data yang telah dikumpulkan. Dari hasil olah data yang dilaksanakan maka didapat simpulan bahwa terdapat pengaruh pendidikan kesehatan terhadap kualitas hidup ibu pasca salin 0-12 bulan. Dengan hasil nilai signifikasi p= 0.000 yaitu p ≤ 0.05.
Kajian Daya Beli Masyarakat Kabupaten Bogor Tahun 2021
Authors: Wijayanti Windi 
Published: March 2024

Pandemi Covid-19 memberikan dampak besar terhadap aspek kehidupan khususnya perekonomian tahun 2020. Dampak tersebut dirasakan oleh sektor ketenagakerjaan Kabupaten Bogor dimana tingkat pengangguran terbuka mencapai 5,4 juta jiwa. Selain itu, juga berdampak pada laju pertumbuhan ekonomi yang mengalami penurunan secara signifikan diangka -1,77%. Peningkatan kemiskinan juga terjadi dengan persentase sebesar 7,69%. Penelitian ini berbentuk survei dengan menggunakan metode pengambilan sampel bertahap (multistage random sampling). Data dianalisis menggunakan metode statistik. Tujuan penelitian ini adalah untuk mengetahui gambaran dampak Covid-19 dan perubahan daya beli masyarakat terhadap sektor ekonomi strategis dan dunia usaha. Hasil penelitian menunjukkan respon masyarakat terhadap dampak Covid-19 adalah responsif yang disebabkan pemahaman masyarakat tentang Covid-19 sangat baik. Mayoritas masyarakat Kabupaten Bogor mengalami penurunan penghasilan. Lebih dari setengah masyarakat memperoleh bantuan sosial Covid-19 melalui program JPS. Adapun faktor-faktor dominan yang menurut pendapat masyarakat dapat meningkatkan daya beli adalah berakhirnya pandemi Covid-19 sebesar 35.42%, penghasilan meningkat sebesar 33.89% dan bansos sebesar 16.94%. Kemampuan daya beli masyarakat Kabupaten Bogor menunjukkan terjadi kenaikan daya beli sebesar 5% pada kelompok rumah tangga dan sebesar 20% pada kelompok industri Sementara, penurunan kemampuan daya beli kelompok rumah tangga hanya sebesar 7,3% dan kelompok industri sebesar 6,3%.
Validation of CDC45 as a novel biomarker for diagnosis and prognosis of gastric cancer
Authors: Wu Lihua , Gao Gan , Mi Hui , Luo Zhou , Wang Zheng , Liu Yongdong , Wu Liangyan , Long Haihua , Shen Yongqi 
Published: March 2024

Background
Cell division cycle protein 45 (CDC45) has been demonstrated to play vital roles in the progression of various malignancies. However, the clinical significance of CDC45 in gastric cancer (GC) remains unreported.

Method
In this study, we employed the TCGA database and the TCGA & GTEx dataset to compare the mRNA expression levels of CDC45 between gastric cancer tissues and adjacent or normal tissues (p < 0.05 was considered statistically significant), which was further validated in multiple datasets including GSE13911, GSE29272, GSE118916, GSE66229, as well as RT-qPCR. Furthermore, we harnessed the Human Protein Atlas (HPA) to evaluate the protein expression of CDC45, which was subsequently verified through immunohistochemistry (IHC). To ascertain the diagnostic utility of CDC45, receiver operating characteristic (ROC) curves and the area under the ROC curve (AUC) were calculated in TCGA database, and further validated it in TCGA & GTEx and GSE66229 datasets. The Kaplan–Meier method was used to reveal the prognostic importance of CDC45 in The Cancer Genome Atlas (TCGA) database and authenticated through the GSE66229, GSE84433, and GSE84437 datasets. Through cBioPortal, we identified co-expressed genes of CDC45, and pursued enrichment analysis. Additionally, we availed gene set enrichment analysis (GSEA) to annotate the biological functions of CDC45.

Results
Differential expression analysis revealed that CDC45 was significantly upregulated at both the mRNA and protein levels in GC (all p < 0.05). Remarkably, CDC45 emerged as a promising prognostic indicator and a novel diagnostic biomarker for GC. In a comprehensive the drug susceptibility analysis, we found that patients with high expression of CDC45 had high sensitivity to various chemotherapeutic agents, among which 5-fluorouracil, docetaxel, cisplatin, and elesclomol were most evident. Furthermore, our findings suggested a plausible association between CDC45 and immune cell infiltration. Enrichment analysis revealed that CDC45 and its associated genes may play crucial roles in muscle biofunction, whereas GSEA demonstrated significant enrichment of gene sets pertaining to G protein-coupled receptor ligand binding and G alpha (i) signaling events.

Conclusion
Our study elucidates that upregulation of CDC45 is intricately associated with immune cell infiltration and holds promising potential as a favorable prognostic marker and a novel diagnostic biomarker for GC.
Challenges in Millennials Investment Decision: A Study of Behavioural Biases
Authors: Fatkhurrozi Muhammad , Innayah Maulida Nurul , Tubastuvi Naelati , Ikhsani Mastur Mujib 
Published: March 2024

Aims: This research aimed to analyze the effect of Cognitive Dissonance Bias, Overconfidence Bias, Herding Bias, Endowment Bias, and Confirmation Bias on the investment decisions of the millennial generation in the capital market.
Study Design: The sampling method used in this study was purposive sampling, which obtained 128 respondents.
Place and Duration of Study: The research was conducted with investors in Banyumas Regency.
Methodology: This research method uses the SEM (Structural Equation Modeling) analysis method with the Partial Least Square (PLS) approach. Each hypothesis is tested to understand the relationship between variables. To test the validity and reliability of research using an outer model. Hypothesis testing uses inner models.
Results: The results of this study showed that cognitive dissonance bias, overconfidence bias, and endowment bias have an effect on investment decisions. However, herding bias and confirmation bias do not affect investment decisions.
Conclusion: To increase investment opportunities, investors must pay attention to cognitive dissonance bias, overconfidence bias, and endowment bias because they can cause investment failure. Investors must also pay attention to information circulating in the media because analysis needs the latest information on investment transaction targets to avoid investment failure.
Over-Expression of EFNA2 in Lung Adenocarcinoma: EFNA2 Gene Expression Correlates with Shortened Survival
Authors: Liu Chunmei , Wu Yanjiao , Zhou Huandi , Ge Xiaohui , Chang Xiaojing , Wang Guohui , Xue Xiaoying 
Published: March 2024

Background: The incidence of lung adenocarcinoma (LUAD) is increasing worldwide with different prognosis. Ephrin-A2（EFNA2), a member of the Eph/ephrin family, is associated with tumor progression. However, the correlations of EFNA2 with prognosis in LUAD remain unclear. The purpose of this article is to analyze the impact of EFNA2 on the prognosis of LUAD patients through TCGA, Oncomine, and GEPIA databases, and to explore its possible mechanisms.
Methods: This article found a significant correlation between EFNA2 and shortened survival in LUAD patients through TCGA, Oncomine, and GEPIA database analysis. Therefore, we further invested the relationship between the expression and prognostic value of the EFNA2 gene in LUAD
patients. Sequential data filtering (survival analysis, independent prognostic analysis, and clinicalcorrelation analysis) was performed. EFNA2 expression was analyzed by the Oncomine database and Tumor Immune Estimation Resource (TIMER). We evaluated the influence of EFNA2 on clinical prognosis using Kaplan-Meier plotter, the PrognoScan database and Gene Expression Profiling Interactive Analysis (GEPIA). The correlation between EFNA2 and cancer immune infiltrates was investigated by TIMER. In addition, correlations between EFNA2 expression and gene marker sets of immune infiltrates were analyzed by TIMER and GEPIA. In addition, gene enrichment analysis was performed by Metascape. Finally, a co-expression analysis was performed by the Oncomine database.
Results: A cohort of LUAD patients showed that high EFNA2 expression was associated with poorer overall survival (OS), disease-free survival (DFS) by TCGA, and EFNA2 was significantly associated with stage in LUAD. In addition, EFNA2 expression was positively correlated with infiltrating levels of B cells and CD8+ T cells. Moreover, the differential expression of EFNA2 was significantly higher in lung adenocarcinoma compared with that in normal controls. Specifically, EFNA2 was positively associated with ADAMTSL5, REEP6, PCSK4, C19orf25, and ANAPC2.
Conclusions: Our data indicate that EFNA2 is a potential diagnostic and prognostic biomarker and a promising molecular therapeutic target to attenuate LUAD progression.
Positive association of the Disrupted‐in‐Schizophrenia‐1 gene (DISC1) with schizophrenia in the Chinese han population
Authors: Qu Mei , Tang Fulei , Yue Weihua , Ruan Yan , Lu Tianlan , Liu Zhonghua , Zhang Handi , Han Yonghua , Zhang Darong , Wang Fei , Zhang Dai 
Published: February 2007

AbstractDisrupted‐in‐Schizophrenia‐1 (DISC1) is located on 1q42.1, one of the most promising susceptibility loci in schizophrenia linkage studies. A non‐synonymous genetic variation rs821616 (Ser704Cys) in DISC1, has recently been shown to be associated with schizophrenia in family‐based study [Callicott et al. (2005); Proc Natl Acad Sci USA 102: 8627–8632]. In order to further confirm this issue, we examined four single nucleotide polymorphisms (SNPs) in a chromosomal region spanning 42 kb of this gene, namely rs821616, rs821597, rs4658971, and rs843979, in Chinese sample of 313 schizophrenia patients and 317 healthy controls. Our results showed that two SNPs had strong associations with schizophrenia (rs821616: Allele A > T, χ2 = 7.8006, df = 1, P = 0.0052; Genotype, χ2 = 7.7935, df = 2, P = 0.0203; rs821597: Allele A > G, χ2 = 9.5404, df = 1, P = 0.0020; Genotype, χ2 = 12.2780, df = 2, P = 0.0022). When haplotypes were constructed with two, three, and four markers, a number of haplotype combinations, especially those including rs821616 and rs821597, were significantly associated with schizophrenia. Furthermore, there was a strong evidence for association in a four‐marker haplotype analysis (χ2 = 7.686, df = 4, P = 0.005581, corrected P = 0.006199). Although the case‐control and family‐based association studies both suggest that DISC1 gene may play a role in genetic susceptibility to schizophrenia, the risk haplotypic combinations have subtle differences in the two studies. Our findings provide further evidence for DISC1 as a predisposing gene involved in schizophrenia in the Chinese Han Population. © 2007 Wiley‐Liss, Inc.