bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loss of the eukaryotic initiation factor 3f in melanoma
Authors: Doldan Adriana , Chandramouli Anupama , Shanas Reneé , Bhattacharyya Achyut , Leong Stanley P.L. , Nelson Mark A. , Shi Jiaqi 
Published: March 2008

AbstractAberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear. Initial studies from our group indicated that eIF3f expression is decreased in melanoma. Overexpression of eIF3f inhibits translation and induces apoptosis in melanoma cells. The eIF3f gene is located at chromosome region 11p15.4. Loss of 11p15.4 is a common event in many tumors including melanoma. In order to investigate the molecular mechanism of the decreased expression of eIF3f in melanoma, we performed loss of heterozygosity (LOH) analysis in 24 melanoma specimens using three microsatellite markers encompassing the eIF3f gene. We showed that the prevalence of LOH ranged from 75% to 92% in melanoma. We also performed eIF3f gene copy number analysis using quantitative real‐time PCR to further confirm the specific allelic loss of the eIF3f gene in melanoma. We demonstrated a statistically significant decrease of the eIF3f gene copy number in melanoma compared with normal tissues with a tumor/normal ratio of 0.52. To further elucidate the somatic genetic alterations, we carried out mutation analysis covering the entire coding region and 5′UTR of the eIF3f gene in melanoma tissues and cell lines. Despite some polymorphisms, we did not find any mutations. Furthermore, immunohistochemistry analysis demonstrated that eIF3f protein expression is decreased in melanoma compared to benign nevi. These data provide new insight into the understanding of the molecular pathogenesis of eIF3f during melanoma tumorigenesis. © 2008 Wiley‐Liss, Inc.
Populations of p53 codon 270 CGT to TGT mutant cells in SKH‐1 mouse skin tumors induced by simulated solar light
Authors: Verkler Tracie L. , Delongchamp Robert R. , Couch Letha H. , Miller Barbara J. , Warbritton Alan , Mellick Paul W. , Howard Paul C. , Parsons Barbara L. 
Published: March 2008

AbstractThe p53 codon 270 CGT to TGT mutation was investigated as a biomarker of sunlight‐induced mutagenesis and carcinogenesis. The relationship between tumor development and abundance of this hotspot mutation was analyzed in mouse skin tumors induced by chronic exposure to simulated solar light (SSL). The 24 tumors analyzed had similar growth kinetics, with an average doubling time of ∼16.4 d. Levels of the p53 codon 270 mutation were quantified in the 24 mouse skin tumors using allele‐specific competitive blocker‐polymerase chain reaction (ACB‐PCR). All tumors contained measurable amounts of the mutation. The p53 codon 270 CGT to TGT mutant fraction (MF) ranged from 2.29 × 10−3 to 9.42 × 10−2, with 3.26 × 10−2 as the median. These p53 MF measurements are lower than expected for an initiating mutation involved in the development of tumors of monoclonal origin. There was no evidence of a correlation between p53 codon 270 MF and either tumor area or an estimate of tumor cell number. Thus, the data do not support the idea that p53 mutation accumulates linearly during tumor development. To investigate how p53 mutation was distributed within tumors, 19 needle biopsies from seven different tumors were analyzed by ACB‐PCR. This analysis demonstrated that p53 codon 270 mutation is heterogeneously distributed within tumors. The long‐term goal of this research is to combine morphological and p53 MF measurements from tissues corresponding to the various stages of tumor development, in order to derive mathematical models relating the p53 codon 270 mutation to the development of SSL‐induced skin tumors. Published 2008 Wiley‐Liss, Inc.
Genome wide transcriptional profiling in breast cancer cells reveals distinct changes in hormone receptor target genes and chromatin modifying enzymes after proteasome inhibition
Authors: Kinyamu H. Karimi , Collins Jennifer B. , Grissom Sherry F. , Hebbar Pratibha B. , Archer Trevor K. 
Published: March 2008

AbstractSteroid hormone receptors, like glucocorticoid (GR) and estrogen receptors (ER), are master regulators of genes that control many biological processes implicated in health and disease. Gene expression is dependent on receptor levels which are tightly regulated by the ubiquitin‐proteasome system. Previous studies have shown that proteasome inhibition increases GR, but decreases ER‐mediated gene expression. At the gene expression level this divergent role of the proteasome in receptor‐dependent transcriptional regulation is not well understood. We have used a genomic approach to examine the impact of proteasome activity on GR‐ and ER‐mediated gene expression in MCF‐7 breast cancer cells treated with dexamethasone (DEX) or 17β‐estradiol (E2), the proteasome inhibitor MG132 (MG) or MG132 and either hormone (MD or ME2) for 24 h. Transcript profiling reveals that inhibiting proteasome activity modulates gene expression by GR and ER in a similar manner in that several GR and ER target genes are upregulated and downregulated after proteasome inhibition. In addition, proteasome inhibition modulates receptor‐dependent genes involved in the etiology of a number of human pathological states, including multiple myeloma, leukemia, breast/prostate cancer, HIV/AIDS, and neurodegenerative disorders. Importantly, our analysis reveals that a number of transcripts encoding histone and DNA modifying enzymes, prominently histone/DNA methyltransferases and demethylases, are altered after proteasome inhibition. As proteasome inhibitors are currently in clinical trials as therapy for multiple myeloma, HIV/AIDS and leukemia, the possibility that some of the target molecules are hormone regulated and chromatin modifying enzymes is intriguing in this era of epigenetic therapy. Published 2008 Wiley‐Liss, Inc.
Falls and gait disturbances in Huntington's disease
Authors: Grimbergen Yvette A.M. , Knol Mirjam J. , Bloem Bastiaan R. , Kremer Berry P.H. , Roos Raymund A.C. , Munneke Marten 
Published: March 2008

AbstractFalls are common in patients with Huntington's disease, but the incidence, falling circumstances and contributing factors have never been examined. We recorded falls in 45 early to midstage Huntington's disease patients, both retrospectively (12 months) and prospectively (3 months). Fall rates were related to relevant baseline measures, including the Unified Huntington's Disease Rating Scale (UHDRS) and quantitative measures of balance (using angular velocity sensors) and gait (using a pressure‐sensitive walkway). Balance and gait measures were compared between patients and 27 healthy age‐matched controls. Twenty‐seven patients (60%) reported two or more falls in the previous year and were classified as fallers. During prospective follow‐up 40% reported at least one fall. A high proportion of falls (72.5%) caused minor injuries. Compared to nonfallers, fallers showed significantly higher scores for chorea, bradykinesia and aggression, as well as lower cognitive scores. Compared to controls, Huntington patients had a decreased gait velocity (1.15 m/s versus 1.45 m/s, P < 0.001) and a decreased stride length (1.29 m versus 1.52 m, P < 0.001). These abnormalities were all significantly greater in fallers compared to nonfallers. In addition, fallers had an increased stride length variability and a significantly greater trunk sway in medio‐lateral direction compared to nonfallers. We conclude that falls are common in Huntington's disease. Contributing factors include a combination of “motor” deficits (mainly gait bradykinesia, stride variability and chorea, leading to excessive trunk sway), as well as cognitive decline and perhaps behavioral changes. These factors should be considered as future targets for therapies that aim to reduce falls in Huntington's disease. © 2008 Movement Disorder Society
Parkinson's disease‐cognitive rating scale: A new cognitive scale specific for Parkinson's disease
Authors: Pagonabarraga Javier , Kulisevsky Jaime , Llebaria Gisela , García‐Sánchez Carmen , Pascual‐Sedano Berta , Gironell Alexandre 
Published: March 2008

AbstractCognitive defects associated with cortical pathology may be a marker of dementia in Parkinson's disease (PD). There is a need to improve the diagnostic criteria of PD dementia (PDD) and to clarify the cognitive impairment patterns associated with PD. Current neuropsychological batteries designed for PD are focused on fronto‐subcortical deficits but are not sensitive for cortical dysfunction. We developed a new scale, the Parkinson's Disease‐Cognitive Rating Scale (PD‐CRS), that was designed to cover the full spectrum of cognitive defects associated with PD. We prospectively studied 92 PD patients [30 cognitively intact (CogInt), 30 mild cognitive impairment (MCI), 32 PDD] and 61 matched controls who completed the PD‐CRS and neuropsychological tests assessing the cognitive domains included in the PD‐CRS. Acceptability, construct validity, reliability, and the discriminative properties of the PD‐CRS were examined. The PD‐CRS included items assessing fronto‐subcortical defects and items assessing cortical dysfunction. Construct validity, test‐retest and inter‐rater reliability of PD‐CRS total scores showed an intraclass correlation coefficient >0.70. The PD‐CRS showed an excellent test accuracy to diagnose PDD (sensitivity 94%, specificity 94%). The PD‐CRS total scores and confrontation naming item scores‐assessing “cortical” dysfunction—independently differentiated PDD from non‐demented PD. Alternating verbal fluency and delayed verbal memory independently differentiated the MCI group from both controls and CogInt. The PD‐CRS appeared to be a reliable and valid PD‐specific battery that accurately diagnosed PDD and detected subtle fronto‐subcortical deficits. Performance on the PD‐CRS showed that PDD is characterized by the addition of cortical dysfunction upon a predominant and progressive fronto‐subcortical impairment. © 2008 Movement Disorder Society
The montreal cognitive assessment as a screening tool for cognitive impairment in Parkinson's disease
Authors: Gill David J. , Freshman Arielle , Blender Jennifer A. , Ravina Bernard 
Published: March 2008

AbstractCognitive impairment is common in Parkinson's disease (PD) and can occur early in the disease course. No effective screening test exists for detection of early or mild cognitive impairment in PD. We examined the Montreal Cognitive Assessment (MoCA) as a screening tool for cognitive dysfunction in PD. The test–retest intraclass correlation coefficient was 0.79 and the interrater intraclass correlation coefficient was 0.81. The correlation coefficient between the MoCA and a neuropsychologic battery was 0.72. The MoCA is reliable and valid in the PD population and warrants further study as a screening tool for cognitive dysfunction. © 2008 Movement Disorder Society
Numerical simulation of fully saturated porous materials
Authors: Jeremić Boris , Cheng Zhao , Taiebat Mahdi , Dafalias Yannis 
Published: March 2008

AbstractFully coupled, porous solid–fluid formulation, implementation and related modeling and simulation issues are presented in this work. To this end, coupled dynamic field equations with u−p−U formulation are used to simulate pore fluid and soil skeleton (elastic–plastic porous solid) responses. Present formulation allows, among other features, for water accelerations to be taken into account. This proves to be useful in modeling dynamic interaction of media of different stiffnesses (as in soil–foundation–structure interaction). Fluid compressibility is also explicitly taken into account, thus allowing excursions into modeling of limited cases of non‐saturated porous media. In addition to these features, present formulation and implementation models in a realistic way the physical damping, which dissipates energy. In particular, the velocity proportional damping is appropriately modeled and simulated by taking into account the interaction of pore fluid and solid skeleton. Similarly, the displacement proportional damping is physically modeled through elastic–plastic processes in soil skeleton. An advanced material model for sand is used in present work and is discussed at some length. Also explored in this paper are the verification and validation issues related to fully coupled modeling and simulations of porous media.Illustrative examples describing the dynamical behavior of porous media (saturated soils) are presented. The verified and validated methods and material models are used to predict the behavior of level and sloping grounds subjected to seismic shaking. Copyright © 2008 John Wiley & Sons, Ltd.
Study of the mixed finite volume method for Stokes and Navier‐Stokes equations
Authors: Droniou Jérôme , Eymard Robert 
Published: March 2008

AbstractWe present finite volume schemes for Stokes and Navier‐Stokes equations. These schemes are based on the mixed finite volume introduced in (Droniou and Eymard, Numer Math 105 (2006), 35‐71), and can be applied to any type of grid (without “orthogonality” assumptions as for classical finite volume methods) and in any space dimension. We present numerical results on some irregular grids, and we prove, for both Stokes and Navier‐Stokes equations, the convergence of the scheme toward a solution of the continuous problem. © 2008 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq, 2009
ARIMA, cointegration, Kalman‐filter, α ‐stable distributions
Authors: Emmenegger Jean‐François , Bardadym Tamara , Pervukhina Elena , Serbinenko Anna 
Published: March 2008

AbstractA group of scientists, from Ukraine, the United Kingdom and Switzerland met at the 3rd International Congress on Industrial and Applied Mathematics (ICIAM95) Hamburg. They decided to pool their applied research efforts and experiences in the domain of mathematics, statistics and economics and to collaborate in empirical research on the subject of the transitional economies of Ukraine and Eastern Europe after 1989. The activity started in autumn 1995 within the framework of a project titled Analysis of Economic and Environmental Time Series (AEETS).At theMinisymposium Cointegrating, Kalman Filtering of Economic Time Series, α‐stable Distributions, of the ICIAM07 in Zurich, the AEETS group has presented a sample of recently treated questions. In this abstract two of these subjects are summarised. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A speculative transmission scheme for scheduling‐latency reduction
Authors: Iliadis Ilias , Minkenberg Cyriel 
Published: March 2008

AbstractLow latency is a critical requirement in some switching applications, specifically in parallel computer interconnection networks. The minimum latency in switches with centralized scheduling comprises two components, namely, the control‐path latency and the data‐path latency, which in a practical high‐capacity, distributed switch implementation can be far greater than the cell duration. We introduce a speculative transmission scheme to significantly reduce the average control‐path latency by allowing cells to proceed without waiting for a grant, under certain conditions. It operates in conjunction with any centralized matching algorithm to achieve a high maximum utilization and incorporates a reliable delivery mechanism to deal with failed speculations. The speculative transmission scheme is employed in a non‐blocking N ×N R input‐queued crossbar switch with R receivers per output. The control‐path latency can be almost entirely eliminated for loads up to 50%. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Analysis of the blunting anti‐wrapping strategy
Authors: Jackson Kenneth R. , Nedialkov Ned S. , Neher Markus 
Published: March 2008

AbstractInterval methods for ODEs often face two obstacles in practical computations: the dependency problem and the wrapping effect. Taylor model methods, which have been developed by Berz and his group, have recently attracted attention. By combining interval arithmetic with symbolic calculations, these methods suffer far less from the dependency problem than traditional interval methods for ODEs. By allowing nonconvex enclosure sets for the flow of a given initial value problem, Taylor model methods have also a high potential for suppressing the wrapping effect.Makino and Berz [1] advocate the so‐called blunting method. In this paper, we analyze the blunting method (as an interval method) for a linear model ODE. We compare its convergence behavior with that of the well‐known QR interval method. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Cellular rubber: Theoretical investigation on the basis of the mixture of theory and experiments
Authors: Johlitz Michael , Diebels Stefan , Steeb Holger 
Published: March 2008

AbstractIn this contribution we investigate a compressible cellular rubber experimentally and theoretically. In an appropriate model we apply the theory of porous media to describe the viscoelastic properties. The model parameters are identified by an algorithm based on evolution strategies. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Scalable solver software
Authors: Keyes David E. 
Published: March 2008

AbstractTowards Optimal Petascale Simulations (TOPS) is a scalable solver software project based on domain decomposed parallelization to research, implement, and support in collaborations with users an open‐source package for large‐scale discretized PDE problems. Optimal complexity methods, such as multigrid/multilevel preconditioners, keep the time spent in dominant algebraic kernels close to linear in discrete problem size as the applications scale on massively parallel computers. Krylov accelerators and Jacobian‐free variants of Newton's method, as appropriate, are wrapped around the multilevel methods to deliver robustness in multirate, multiscale coupled systems, which are solved either implicitly or in more traditional forms of operator splitting. The TOPS software framework is being extended beyond direct computational simulation to computational optimization, including design, control, and inverse problems. We outline and illustrate the philosophy of TOPS. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Finite‐element formulations of shear localization in granular materials
Authors: Tuyet Trinh Bach , Hackl Klaus 
Published: March 2008

AbstractDisplacement and mixed finite element formulations of shear localization in granular materials are presented. The formulations are based on hypoplastic constitutive laws for soils and the mixed‐enhanced treatment involving displacement, strain and stress rates as independently varied fields. Included in these formulations are the standard displacement method, the three‐field mixed formulation, the method of incompatible modes, the enhanced assumed strain method and the mixed enhanced strain method. Several numerical examples demonstrating the capability and performance of the different finite element formulations are presented. The numerical results are compared with available experimental data of Hostun RF sand and numerical results of Karlsruhe sand on biaxial tests. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The free‐discontinuity problem of inverse crack identification from boundary measurements
Authors: Tsotsova Rumena 
Published: March 2008

AbstractThe inverse crack identification of planar cracks from elastostatics boundary measurements is regarded as free‐discontinuity problem in respect to the unknown displacement field and the discontinuity region of the cracked body. The proposed solution strategy is based on the variational approximation of the sharp interface problem by elliptic functionals developed by Ambrosio and Tortorelli. The numerical calculation is realized by the finite element method. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
3D complex structures imaging based on acoustic wave equation
Authors: Zhang Wensheng 
Published: March 2008

AbstractIn this paper, a general expression of the 3D hybrid imaging method based on acoustic wavefield extrapolation is presented. Moreover, the planewave synthesization method is given. The numerical results of 3D shot‐profile migration and planewave synthesization migration for the SEG/EAEG 3D benchmark model show the good imaging ability of the hybrid imaging method. This method can be applied in field data processing. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Cardiac liposarcoma and bilateral ovarian mature teratoma in a patient with congenital heart disease and f‐anisosplenia
Authors: Pollono  , Drut Ricardo 
Published: March 2008

AbstractA 10‐year‐old female with atrial septal defect presented with bilateral ovarian mature cystic teratomas. Three spleniculi adjacent to the main spleen were noticed while the endoscopic surgery. Two years later a heart tumor was discovered which led to death. Pathologic examination of samples of the mass proved it to be a liposarcoma. The unusual combination of atrial septal defect, f‐anisosplenia (female, congenital heart disease, multiple unevenly‐sized spleens, left lung type pulmonary isomerism), bilateral ovarian mature cystic teratomas and liposarcoma of the heart appears to be a unique presentation. Pediatr Blood Cancer 2008;51:304–305. © 2008 Wiley‐Liss, Inc.
Synthesis, characterization and application of poly[(1‐vinyl‐2‐pyrrolidone)‐co‐(2‐hydroxyethyl methacrylate)] as controlled‐release polymeric system for 2,4‐dichlorophenoxyacetic chloride using an ultrafiltration technique
Authors: del C Pizarro Guadalupe , Marambio Oscar G , Jeria‐Orell Manuel , Avellán Miguel C , Rivas Bernabé L 
Published: March 2008

AbstractBACKGROUND: Polymers supporting chemicals used in agriculture have recently been developed to overcome the serious environmental problems of conventional agrochemicals. The success of these formulations is based on a suitable choice of polymer support. Degradable polymeric hydrogels are of particular interest. The gradual release of the bioactive agent can be achieved by hydrolytic or enzymatic cleavage of the linking bond.RESULTS: In this context, poly[(1‐vinyl‐2‐pyrrolidone)‐co‐(2‐hydroxyethyl methacrylate)] [poly(NVP‐co‐HEMA)] has been used as a bioactive carrier reagent. Herein, we report a controlled‐release system with the herbicide 2,4‐dichlorophenoxyacetic acid (2,4‐D) using an ultrafiltration system. Hydrolysis was studied by testing the release at various pH values. A high release with poly(NVP‐co‐HEMA)–2,4‐D was observed at pH = 7 and 10 after two days (Z = 2). The release percentage of copolymer–herbicide increased at pH = 10. It showed release values between 79.0 and 94.5%. Poly(NVP‐co‐HEMA)–herbicide can release a bioactive compound in aqueous solution at pH = 3, 7 and 10.CONCLUSION: Based on the results of homogeneous hydrolysis, it is argued that the herbicide release rate depends on the pH of the reaction environment. This functional polymer could be employed as a biodegradable material for applications in agrichemical release. Copyright © 2008 Society of Chemical Industry