bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consequences of Amyloid‐β Deficiency for the Liver
Authors: Buniatian Gayane Hrachia , Schwinghammer Ute , Tremmel Roman , Cynis Holger , Weiss Thomas S. , Weiskirchen Ralf , Lauschke Volker M. , Youhanna Sonia , Ramos Isbaal , Valcarcel Maria , Seferyan Torgom , Rahfeld Jens‐Ulrich , Rieckmann Vera , Klein Kathrin , Buadze Marine , Weber Victoria , Kolak Valentina , Gebhardt Rolf , Friedman Scott L. , Müller Ulrike C. , Schwab Matthias , Danielyan Lusine 
Published: March 2024

AbstractThe hepatic content of amyloid beta (Aβ) decreases drastically in human and rodent cirrhosis highlighting the importance of understanding the consequences of Aβ deficiency in the liver. This is especially relevant in view of recent advances in anti‐Aβ therapies for Alzheimer's disease (AD). Here, it is shown that partial hepatic loss of Aβ in transgenic AD mice immunized with Aβ antibody 3D6 and its absence in amyloid precursor protein (APP) knockout mice (APP‐KO), as well as in human liver spheroids with APP knockdown upregulates classical hallmarks of fibrosis, smooth muscle alpha‐actin, and collagen type I. Aβ absence in APP‐KO and deficiency in immunized mice lead to strong activation of transforming growth factor‐β (TGFβ), alpha secretases, NOTCH pathway, inflammation, decreased permeability of liver sinusoids, and epithelial‐mesenchymal transition. Inversely, increased systemic and intrahepatic levels of Aβ42 in transgenic AD mice and neprilysin inhibitor LBQ657‐treated wild‐type mice protect the liver against carbon tetrachloride (CCl4)‐induced injury. Transcriptomic analysis of CCl4‐treated transgenic AD mouse livers uncovers the regulatory effects of Aβ42 on mitochondrial function, lipid metabolism, and its onco‐suppressive effects accompanied by reduced synthesis of extracellular matrix proteins. Combined, these data reveal Aβ as an indispensable regulator of cell–cell interactions in healthy liver and a powerful protector against liver fibrosis.
Elesclomol Loaded Copper Oxide Nanoplatform Triggers Cuproptosis to Enhance Antitumor Immunotherapy
Authors: Lu Xufeng , Chen Xiaodong , Lin Chengyin , Yi Yongdong , Zhao Shengsheng , Zhu Bingzi , Deng Wenhai , Wang Xiang , Xie Zuoliang , Rao Shangrui , Ni Zhonglin , You Tao , Li Liyi , Huang Yingpeng , Xue Xiangyang , Yu Yaojun , Sun Weijian , Shen Xian 
Published: March 2024

AbstractThe induction of cuproptosis, a recently identified form of copper‐dependent immunogenic cell death, is a promising approach for antitumor therapy. However, sufficient accumulation of intracellular copper ions (Cu2+) in tumor cells is essential for inducing cuproptosis. Herein, an intelligent cuproptosis‐inducing nanosystem is constructed by encapsulating copper oxide (CuO) nanoparticles with the copper ionophore elesclomol (ES). After uptake by tumor cells, ES@CuO is degraded to release Cu2+ and ES to synergistically trigger cuproptosis, thereby significantly inhibiting the tumor growth of murine B16 melanoma cells. Moreover, ES@CuO further promoted cuproptosis‐mediated immune responses and reprogrammed the immunosuppressive tumor microenvironment by increasing the number of tumor‐infiltrating lymphocytes and secreted inflammatory cytokines. Additionally, combining ES@CuO with programmed cell death‐1 (PD‐1) immunotherapy substantially increased the antitumor efficacy in murine melanoma. Overall, the findings of this study can lead to the use of a novel strategy for cuproptosis‐mediated antitumor therapy, which may enhance the efficacy of immune checkpoint inhibitor therapy.
An Iodine‐Chemisorption Binder for High‐Loading and Shuttle‐Free Zn–Iodine Batteries
Authors: Wang Kexuan , Li Heng , Xu Zhu , Liu Yupeng , Ge Mingzheng , Wang Huibo , Zhang Hankun , Lu Yunhao , Liu Jilei , Zhang Yanyan , Tang Yuxin , Chen Shi 
Published: March 2024

AbstractAqueous zinc–iodine (Zn–I2) batteries have attracted considerable research interest as an alternative energy storage system due to their high specific capacity, intrinsic safety, and low cost. However, the notorious shuttle effect of soluble polyiodides causes severe capacity loss and poor electrochemical reversibility, restricting their practical usage. Herein, this study reports a bifunctional binder (polyacrylonitrile copolymer, as known as LA133) with strong iodine‐chemisorption capability for aqueous Zn–I2 batteries to suppress polyiodide shuttling. From both calculation and experimental data, this study reveals that the amide and carboxyl groups in LA133 binder can strongly bond to polyiodides, significantly immobilizing them at cathode side. As a result, fewer byproducts, slower hydrogen evolution, and lesser Zn dendrite in the Zn–I2 battery are observed. Consequently, the battery shows high specific capacity (202.8 mAh g−1) with high iodine utilization efficiency (96.1%), and long cycling lifespan (2700 cycles). At the high mass loading of 7.82 mg cm−2, the battery can still retain 83.3% of its initial capacity after 1000 cycles. The specific capacity based on total cathode slurry mass reaches 71.2 mAh g−1, higher than most of the recent works. The strategy opens a new avenue to address the shuttling challenge of Zn–I2 batteries through bifunctional binder.
Photodynamic patterning of living bacterial biofilms with high resolutions for information encryption and antibiotic screening
Authors: Xiao Minghui , Xue Ke , Fu Hao , Wang Jiaxin , Lv Shuyi , Sun Zhencheng , Wang Cheng , Shi Linqi , Zhu Chunlei 
Published: March 2024

AbstractControlling the growth of bacterial biofilms in a specific pattern greatly enhances the study of cell‐to‐cell interactions and paves the way for expanding their biological applications. However, the development of simple, cost‐effective, and highly resolved biopatterning approaches remains a persistent challenge. Herein, a pioneering photodynamic biopatterning technique for the creation of living bacterial biofilms with customized geometries at high resolutions is presented. First of all, an outstanding aggregation‐induced emission photosensitizer is synthesized to enable efficient photodynamic bacterial killing at a low concentration. By combining with custom‐designed photomasks featuring both opaque and transparent patterns, the viability of photosensitizer‐coated bacteria is successfully manipulated by controlling the degree of light transmittance. This process leads to the formation of living bacterial biofilms with specific patterns replicated from the photomask. Such an innovative strategy can be employed to generate living bacterial biofilms composed of either mono‐ or multispecies, with a spatial resolution of approximately 24 µm. Furthermore, its potential applications in information storage/encryption and antibiotic screening are explored. This study provides an alternative way to understand and investigate the intricate interactions among bacteria within 3D biofilms, holding great promise in the controlled fabrication of dynamic biological systems for advanced applications.
Maternal and infant predictors of proinflammatory milk immune activity in Kilimanjaro, Tanzania
Authors: Wander Katherine , Fujita Masako , Mattison Siobhán , Gauck Megan , Duris Margaret , Kiwelu Ireen , Mmbaga Blandina T. 
Published: March 2024

AbstractObjectivesThe immune system of milk (ISOM) creates a mother–infant immune axis that plays an important role in protecting infants against infectious disease (ID). Tradeoffs in the immune system suggest the potential for both protection and harm, so we conceive of two dimensions via which the ISOM impacts infants: promotion of protective activity and control of activity directed at benign targets. High variability in ISOM activity across mother–infant dyads suggests investment the ISOM may have evolved to be sensitive to maternal and/or infant characteristics. We assessed predictors of appropriate and misdirected proinflammatory ISOM activity in an environment of high ID risk, testing predictions drawn from life history theory and other evolutionary perspectives.MethodsWe characterized milk in vitro interleukin‐6 (IL‐6) responses to Salmonella enterica (a target of protective immune activity; N = 96) and Escherichia coli (a benign target; N = 85) among mother–infant dyads in rural Kilimanjaro, Tanzania. We used ordered logistic regression and mixture models to evaluate maternal and infant characteristics as predictors of IL‐6 responses.ResultsIn all models, IL‐6 responses to S. enterica increased with maternal age and decreased with gravidity. In mixture models, IL‐6 responses to E. coli declined with maternal age and increased with gravidity. No other considered variables were consistently associated with IL‐6 responses.ConclusionsThe ISOM's capacities for appropriate proinflammatory activity and control of misdirected proinflammatory activity increases with maternal age and decreases with gravidity. These findings are consistent with the hypothesis that the mother–infant immune axis has evolved to respond to maternal life history characteristics.
COVID‐19 mortality among Massachusetts workers and the association with telework ability, 2020
Authors: Fitzsimmons Kathleen , Hood Malena , Grattan Kathleen , Laing James , Sparer‐Fine Emily 
Published: March 2024

AbstractBackgroundWorking outside the home put some workers at risk for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) exposure and might partly explain elevated coronavirus disease 2019 (COVID‐19) mortality rates in the first months of the pandemic in certain groups of Massachusetts workers. To further investigate this premise, we examined COVID‐19 mortality among Massachusetts workers, with a specific focus on telework ability based on occupation.MethodsCOVID‐19‐associated deaths between January 1 and December 31, 2020 among Massachusetts residents aged 18–64 years were analyzed. Deaths were categorized into occupation‐based quadrants (Q) of telework ability. Age‐adjusted rates were calculated by key demographics, industry, occupation, and telework quadrant using American Community Survey workforce estimates as denominators. Rate ratios (RRs) and 95% confidence intervals comparing rates for quadrants with workers unlikely able to telework (Q2, Q3, Q4) to that among those likely able to telework (Q1) were calculated.ResultsThe overall age‐adjusted COVID‐19‐associated mortality rate was 26.4 deaths per 100,000 workers. Workers who were male, Black non‐Hispanic, Hispanic, born outside the US, and with lower than a high school education level experienced the highest rates among their respective demographic groups. The rate varied by industry, occupation and telework quadrant. RRs comparing Q2, Q3, and Q4 to Q1 were 0.99 (95% confidence interval [CI]: 0.8−1.2), 3.2 (95% CI: 2.6−3.8) and 2.5 (95% CI: 2.0−3.0), respectively.ConclusionFindings suggest a positive association between working on‐site and COVID‐19‐associated mortality. Work‐related factors likely contributed to COVID‐19 among Massachusetts workers and should be considered in future studies of COVID‐19 and similar diseases.
Putting Hybrid Nanomaterials to Work for Biomedical Applications
Authors: Zhang Dong , Chen Yidan , Hao Min , Xia Younan 
Published: March 2024

AbstractHybrid nanomaterials have found use in many biomedical applications. This article provides a comprehensive review of the principles, techniques, and recent advancements in the design and fabrication of hybrid nanomaterials for biomedicine. We begin with an introduction to the general concept of material hybridization, followed by a discussion of how this approach leads to materials with additional functionality and enhanced performance. We then highlight hybrid nanomaterials in the forms of nanostructures, nanocomposites, metal–organic frameworks, and biohybrids, including their fabrication methods. We also showcase the use of hybrid nanomaterials to advance biomedical engineering in the context of nanomedicine, regenerative medicine, diagnostics, theranostics, and biomanufacturing. Finally, we offer perspectives on challenges and opportunities.
The Versatile Establishment of Charge Storage in Polymer Solid Electrolyte with Enhanced Charge Transfer for LiF‐Rich SEI Generation in Lithium Metal Batteries
Authors: Liang Weizhong , Zhou Xuanyi , Zhang Biao , Zhao Zishao , Song Xin , Chen Ke , Wang Li , Ma Zengsheng , Liu Jun 
Published: March 2024

AbstractThe solid‐state electrolyte interface (SEI) between the solid‐state polymer electrolyte and the lithium metal anode dramatically affects the overall battery performance. Increasing the content of lithium fluoride (LiF) in SEI can help the uniform deposition of lithium and inhibit the growth of lithium dendrites, thus improving the cycle stability performance of lithium batteries. Currently, most methods of constructing LiF SEI involve decomposing the lithium salt by the polar groups of the filler. However, there is a lack of research reports on how to affect the SEI layer of Li‐ion batteries by increasing the charge transfer number. In this study, a porous organic polymer with “charge storage” properties was prepared and doped into a polymer composite solid electrolyte to study the effect of sufficient charge transfer on the decomposition of lithium salts. The results show in contrast to porphyrins, the unique structure of POF allows for charge transfer between each individual porphyrin. Therefore, during TFSI− decomposition to the formation of LiF, TFSI− can obtain sufficient charge, thereby promoting the break of C−F and forming the LiF‐rich SEI. Compared with single porphyrin (0.423 e−), POF provides 2.7 times more charge transfer to LiTFSI (1.147 e−). The experimental results show that Li//Li symmetric batteries equipped with PEO‐POF can be operated stably for more than 2700 h at 60 °C. Even the Li//Li (45 μm) symmetric cells are stable for more than 1100 h at 0.1 mA cm−1. In addition, LiFePO4//PEO‐POF//Li batteries have excellent cycling performance at 2 C (80 % capacity retention after 750 cycles). Even LiFePO4//PEO‐POF//Li (45 μm) cells have excellent cycling performance at 1 C (96 % capacity retention after 300 cycles). Even when the PEO‐base is replaced with a PEG‐base and a PVDF‐base, the performance of the cell is still significantly improved. Therefore, we believe that the concept of charge transfer offers a novel perspective for the preparation of high‐performance assemblies.
Precisely Patterned Channels in a Vertical Organic Electrochemical Transistor with a Diazirine Photo‐Crosslinker
Authors: Lai Yueping , Cheng Jingliang , Xie Miao , Chen Jianhua , Zhu Guichuan , Huang Wei , Feng Liang‐Wen 
Published: March 2024

AbstractOrganic electrochemical transistors (OECTs) rely on both efficient ionic doping/de‐doping process and carrier transport in the mixed ionic‐electronic channel under the modulation of gate bias. Moreover, channels that hold photopatterning capability are highly desired to minimize parasitic capacitance and simplify the fabrication process/cost. However, yielding photo‐patternable channels with both precise/robust patterning capability and controllable ionic‐electronic coupling is still challenging. Herein, double‐end trifluoromethyl diazirines (DtFDA) with different chain lengths are introduced in the OECT channel to act as both photo‐crosslinker and medium to regulate ionic‐electronic transport. Specifically, high‐resolution patterns with a minimum line width/gap of 2 μm are realized in p(g2T‐T) or Homo‐gDPP based channels by introducing DtFDA. Maximum transconductances of 68.6 mS and 81.6 mS, current on/off ratio of 106 and 107 (under a drain voltage of only ±0.1 V), are achieved in p‐ and n‐type vertical OECTs (vOECTs), respectively, along with current densities exceeding 1 kA cm−2 and good cycling stability of more than 100,000 cycles (2000 seconds). This work provides a new and facile strategy for the fabrication of vOECT channels with high resolution and high performance via the introduction of a simple and efficient crosslinker.
Lyotropic ionic liquid crystal gels derived from polyimidazolium hydrogen sulfate for enhanced proton conductivity
Authors: Liu Xin , Tan Shuai , Wang Caihong , Wu Yong 
Published: March 2024

AbstractAnisotropic gels developed from polymer networks accommodating lyotropic liquid crystals are promising electrolytes but electrochemically inert polymers prevent ions from being conducted efficiently. In this work, we synthesized protic ionic liquid polymer in lyotropic ionic liquid crystal to improve proton conduction across the polymer skeleton in anisotropic gels. In situ polymerization of 1‐vinylimidazolium hydrogen sulfate ionic liquid dissolved in aqueous 1‐tetradecyl‐3‐methylimidazolium hydrogen sulfate lyotropic liquid crystal gave chemical liquid crystal gels exhibiting both dynamic order and mechanical strength. The protic ionic liquid polymer bridged the hydrogen bond chains between neighboring ionic lyotropic liquid crystal domains to give a proton conductivity of 117 mS cm−1 at 25°C. Macroscopic alignment of the liquid crystal gel achieved by mechanical shearing promoted proton conductivity to 137 mS cm−1. The macroscopically aligned liquid crystal gel acted stably in a fuel cell device, delivering a peak power density 2.95 times higher than the unaligned one. Gelation of lyotropic ionic liquid crystals with protic ionic liquid polymer provides an effective strategy to develop anisotropic gel electrolytes for electrochemical devices.
Unraveling Ferroptosis Mechanisms: Tracking Cellular Viscosity with Small Molecular Fluorescent Probes
Authors: Pareek Niharika , Mendiratta Sana , Kalita Nripankar , Sivaramakrishnan Shreya , Khan Rafique Sanu , Samanta Animesh 
Published: March 2024

AbstractFerroptosis is a recently identified form of regulated cell death characterized by iron accumulation and lipid peroxidation. Numerous functions for ferroptosis have been identified in physiological as well as pathological processes, most notably in the treatment of cancer. The intricate balance of redox homeostasis is profoundly altered during ferroptosis, leading to alteration in cellular microenvironment. One such microenvironment is viscosity among others such as pH, polarity, and temperature. Therefore, understanding the dynamics of ferroptosis associated viscosity levels within organelles is crucial. To date, there are a very few reviews that detects ferroptosis assessing reactive species. In this review, we have summarized organelle's specific fluorescent probes that detects dynamics of microviscosity during ferroptosis. Also, we offer the readers an insight of their design strategy, photophysics and associated bioimaging concluding with the future perspective and challenges in the related field.
Measurement matters: A commentary on the state of the science on patient reported outcome measures (PROMs) in autism research
Authors: Schiltz Hillary K. , Williams Zachary J. , Zheng Shuting , Kaplan‐Kahn Elizabeth A. , Morton Hannah E. , Rosenau Kashia A. , Nicolaidis Christina , Sturm Alexandra , Lord Catherine ,   Autism PROMnet
Published: March 2024

AbstractHigh quality science relies upon psychometrically valid and reliable measurement, yet very few Patient Reported Outcome Measures (PROMs) have been developed or thoroughly validated for use with autistic individuals. The present commentary summarizes the current state of autism PROM science, based on discussion at the Special Interest Group (SIG) at the 2022 International Society for Autism Research (INSAR) Annual Meeting and collective expertise of the authors. First, we identify current issues in autism PROM research including content and construct operationalization, informant‐structure, measure accessibility, and measure validation and generalization. We then enumerate barriers to conducting and disseminating this research, such as a lack of guidance, concerns regarding funding and time, lack of accessible training and professionals with psychometric skills, difficulties collecting large representative samples, and challenges with dissemination. Lastly, we offer future priorities and resources to improve PROMs in autism research including a need to continue to evaluate and develop PROMs for autistic people using robust methods, to prioritize diverse and representative samples, to expand the breadth of psychometric properties and techniques, and to consider developing field specific guidelines. We remain extremely optimistic about the future directions of this area of autism research. This work is well positioned to have an immense, positive impact on our scientific understanding of autism and the everyday lives of autistic people and their families.
Are autistic females at greater risk of suicide? A call for clarity to advance suicide prevention for the whole community
Authors: Kirby Anne V. , Conner Caitlin M. , Mazefsky Carla A. 
Published: March 2024

AbstractUnderstanding suicide risk is critical for supporting prevention. A growing body of evidence shows autistic people are at greater risk for multiple suicide‐related outcomes than non‐autistic people. This commentary is in response to an observed pattern of miscommunication in scientific and community spaces about autistic females having higher risk of suicide. However, it is not always clear who they are being compared with in these statements. To address this confusion, we summarize the current population‐based evidence on autistic suicide risk, highlighting findings related to sex similarities and differences, which actually indicates comparable rates of suicide death among autistic males and females, and mixed findings related to sex differences in risk of other suicidal behaviors. We call for greater clarity in suicide risk communication moving forward focused on outcomes, measurement, sampling methods, and comparison groups to reflect accurate conclusions about existing evidence. Further research is needed about the full range of suicide‐related outcomes for autistic people, including a greater understanding of sex differences as well as potential gender differences to include transgender and nonbinary autistic people. However, studies of sex and gender differences should not overshadow the compelling need for efforts to understand and address the elevated risk of suicidal thoughts, behaviors, and death among autistic people across sex and gender boundaries.
Use of Ferrocenyl Ni(II) and Zn(II) Porphyrins as Active Organic Electrode Materials for Sodium Secondary Batteries
Authors: Zhang Shaoning , Hwang Jinkwang , Phung Quan Manh , Matsumoto Kazuhiko , Hagiwara Rika , Shin Ji‐Young 
Published: March 2024

AbstractThis study investigates the potential use of ferrocenyl‐substituted porphyrins as organic electrode materials for sodium secondary batteries. Expressly, 5,15‐di(ferrocenyl)‐10,20‐di(pentafluorophenyl)porphyrins (free base, Fc−H2Por), along with its zinc (Zn[II] complex, Fc−ZnPor) and nickel (Ni[II] complex, Fc−NiPor) derivatives were synthesized and employed as the electrode materials. The charge‐discharge processes disclosed that the ferrocenyl‐substituted porphyrin compound performs electrochemical processes poorly without chelating metals. In contrast, when the ferrocenyl‐substituted porphyrins were metalated with Ni(II) and Zn(II), they exhibited dual ionic charge‐discharge capabilities, indicating their stable electrochemical properties. In particular, long‐term cycle tests emphasized the superior stability and high Coulombic efficiency of Fc−ZnPor electrodes. Computational calculations provided conclusive evidence of variances in aromatic stabilization energy based on the metal center, significantly influencing the chemical stability and electrochemical performance. These findings can deliver valuable insight for further development and optimizations in energy storage applications.