bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atypical plume-like events drive glutamate accumulation in metabolic stress conditions
Authors: Ziebarth Tim , Pape Nils , Nelson Joel S.E. , van Alphen Fleur I.M. , Kalia Manu , Meijer Hil G.E. , Rose Christine R. , Reiner Andreas 
Published: February 2025

AbstractNeural glutamate homeostasis plays a key role in health and disease. In ischemic conditions, such as stroke, this homeostasis is severely disrupted since energy depletion and ion imbalances lead to more glutamate release and less uptake. We here used the fluorescent glutamate sensor SF-iGluSnFR(A184V) to probe the effects of chemical ischemia on extracellular glutamate dynamicsin situ, using organotypic slice cultures from mouse cortex. SF-iGluSnFR imaging reported spontaneous glutamate release events, which indicate synchronous network activity, similar to calcium signals detected with GCaMP6f. In addition, glutamate imaging revealed local, asynchronous release events, which were atypically large and long-lasting and showed plume-like characteristics. Under baseline conditions plumes occurred with low frequency, were independent of network activity, and persisted in the presence of TTX. Plume induction was strongly favored by blocking glutamate uptake with TFB-TBOA, whereas blocking ionotropic glutamate receptors (iGluRs) suppressed plumes. Upon inducing chemical ischemia plumes became more pronounced and overly abundant, which resulted in large-scale accumulation of extracellular glutamate. Similar plumes were recently also observed in models of cortical spreading depression and migraine. We therefore propose that plumes represent a more general phenomenon induced by glutamate uptake dysfunction, which may contribute to glutamate-related excitotoxicity in various neurodegenerative and neurological disorders.
Phenotypic and Functional Alterations in Peripheral Blood Mononuclear Cell-Derived Microglia in a Primate Model of Chronic Alcohol Consumption
Authors: Hemati Hami , Blanton Madison B. , True Heather E. , Koura Jude , Khadka Rupak , Grant Kathleen A. , Messaoudi Ilhem 
Published: February 2025

ABSTRACTAlcohol-induced dysregulation of microglial activity is associated with neuroinflammation, cognitive decline, heightened risk for neurodegenerative diseases, alcohol dependence, and escalation of alcohol drinking. Given the challenge of longitudinally sampling primary microglia, we optimized anin vitromethod to differentiate peripheral blood mononuclear cells (PBMC) from non-human primates (NHP) into microglia-like cells (induced-microglia; iMGL). The iMGLs displayed transcriptional profiles distinct from those of monocyte progenitors and closely resembling those of primary microglia. Notably, morphological features showed that differentiated iMGLs derived from NHPs with chronic alcohol consumption (CAC) possessed a more mature-like microglial morphology. Additionally, dysregulation in key inflammatory and regulatory markers alongside increased baseline phagocytic activity was observed in CAC-derived IMGLs in the resting state. Phenotypic and functional assessments following LPS stimulation indicated the presence of an immune-tolerant phenotype and enrichment of a CD86+hyper-inflammatory subpopulation in iMGLs derived from ethanol-exposed animals. Collectively, these findings demonstrate thatin vitrodifferentiation of PBMC offers a minimally invasive approach to studying the impact of CAC on microglial function revealing that CAC reshapes both functional and transcriptional profiles of microglia.
Myelination across cortical hierarchies and depths in humans and macaques
Authors: Nishio Monami , Liu Xingyu , Mackey Allyson P. , Arcaro Michael J. 
Published: February 2025

AbstractMyelination is fundamental to brain function, enabling rapid neural communication and supporting neuroplasticity throughout the lifespan. While hierarchical patterns of myelin maturation across the cortical surface are well-documented in humans, it remains unclear which features reflect evolutionarily conserved developmental processes versus human-characteristic adaptations. Moreover, the laminar development of myelin across the primate cortical surface, which shapes hierarchies and supports functions ranging from sensory integration to network communication, has been largely unexplored. Using neuroimaging to measure the T1-weighted/T2-weighted ratio in tissue contrast as a proxy for myelin content, we systematically compared depth-dependent trajectories of myelination across the cortical surface in humans and macaques. We identified a conserved “inside-out” pattern, with deeper layers exhibiting steeper increases in myelination and earlier plateaus than superficial layers. This depth-dependent organization followed a hierarchical gradient across the cortical surface, progressing from early maturation in sensorimotor regions to prolonged development in association areas. Humans exhibited a markedly extended timeline of myelination across both cortical regions and depths compared to macaques, allowing for prolonged postnatal plasticity across the entire cortical hierarchy — from sensory and motor processing to higher-order association networks. This extended potential for plasticity may facilitate the shaping of cortical circuits through postnatal experience in ways that support human-characteristic perceptual and cognitive capabilities.
Meaning for reading: The neurocognitive basis of semantic reading impairment after stroke
Authors: Staples Ryan , Vivian Dickens J. , Dyslin Sara M. , DeMarco Andrew T. , Snider Sarah F. , Friedman Rhonda B. , Turkeltaub Peter E. 
Published: February 2025

AbstractDiagnosis of alexia has historically focused on syndromes, such as surface alexia, which capture discrete patterns of reading deficits observed in some patients, but do not describe the breadth of reading deficits observed in practice. Aphasia research has recently shifted focus to language process impairments rather than syndromic classifications. A similar shift in focus to reading process impairments may improve our diagnostic approach to alexia. Behavioural evidence suggests that semantic processing influences reading aloud, and that semantic deficits in the context of semantic dementia underlie surface alexia. Because stroke rarely causes loss of semantic knowledge and surface alexia as a syndromic diagnosis is unusual after stroke, semantic reading deficits in stroke alexia have not previously been examined systematically. Semantic reading deficits in stroke may not relate to semantic deficits per se, but rather an inability to use semantics to support reading. Imageability, the degree to which a word brings to mind an image, is one index of semantic influences on reading. High imageability words are read more quickly by healthy persons and more accurately following brain damage. Here, we test if deficits of semantic reading after stroke, as indexed by reduced imageability effects, result from semantic or post-semantic processes. Examining nonverbal semantic processing, semantics-phonology mapping, and semantic control in a sample of 56 left-hemisphere stroke survivors, only semantics-phonology mappings predicted the reading advantage for high imageability words over low imageability words. Support vector regression voxel-based lesion symptom mapping revealed that damage along the superior temporal sulcus and underlying white matter, extending into both the middle and superior temporal gyri, reduced the advantage of high imageability over low imageability words during reading, reflecting an inability to use semantics to support reading. A similar cluster related to impairments in semantics-phonology mapping. The imageability and semantics-phonology mapping results overlapped in the left posterior superior temporal sulcus. Support vector regression connectome lesion symptom mapping revealed white matter disconnections within a broad temporoparietal network important for both phonological and semantic processing were associated with a reduction of the imageability advantage during reading. These results demonstrate that, irrespective of syndromic classification, semantic reading deficits occur in left-hemisphere stroke survivors as a result of impaired integration of semantic and phonological representations, and that the left posterior superior temporal sulcus underlies this process. Our results clarify the neurobiology of reading aloud, and support the existence of a post-semantic impairment of semantic reading in left-hemisphere stroke survivors.
Guiding G protein signaling by target enhancement of GPCRs
Authors: Mücher Brix , Garrido-Charles Aida , Cyganek Lukas , Bruegmann Tobias , Dalkara Deniz , Siveke Ida , Herlitze Stefan 
Published: February 2025

AbstractActivation of G protein coupled receptors coupling to the Gi/opathway leads to the activation of G protein-activated inward rectifier potassium channels (GIRK) in a fast membrane-delimited manner in excitable cells. Activation of GIRK causes the hyperpolarization of the cell membrane, where hyperpolarization is dependent on te availability of Gi/ocoupled GPCRs and GIRK. In particular, in optogenetic and chemogenetic experiments neuronal silencing depends on downstream targets of Gi/o-coupled GPCRs. To selectively enhance Gi/omediated GIRK currents, we created expression cassettes consisting of a homomer forming GIRK subunit and various light-activated Gi/o-coupled GPCRs (Melanopsin, Long-wave-sensitive opsin 1, Parapinopsin or Opsin 7b). We demonstrate that light-activation of the GIRK/GPCR constructs induces robust GIRK currents in human embryonic kidney 293 cells, cardiomyocytes and cerebellar Purkinje cells and changes the net effect of G protein signaling of the promiscuous Opn4L from a Gq/11mediated excitation towards an Gi/omediated inhibition. Thus, our tools enhance target selectivity and improve optogenetic control of the Gi/opathway by light in excitable cells.
The built environment and social media: a semi-systematic review of architectural and design disciplines
Authors: Huang Tracy , Maalsen Sophia , Fredericks Joel 
Published: February 2025

PurposeThis paper explores the engagement of architecture and design-related disciplines within the built environment with social media. The study aims to identify key themes, assess the methodologies used and compare the approaches across different disciplines.Design/methodology/approachThe research employs a semi-systematic literature review coupled with thematic analysis. This approach allows for a comprehensive examination of existing studies, identifying key themes, trends and gaps in the current knowledge base. Through this methodology, the paper synthesises diverse perspectives and insights from a wide range of sources.FindingsSocial media data is a valuable tool for understanding architecture and the built environment, but there is a significant divergence in methodologies across disciplines. There is a growing advocacy for mixed-method approaches that would benefit from critical engagement with data that’s underpinned by theoretical frameworks. Such approaches enhance research robustness, support multidisciplinary collaboration and improve the applicability of social media data in design practices.Originality/valueDespite the proliferation of literature on social media and the built environment, there remains a lack of nuanced understanding regarding thematic variations within individual design disciplines and the specific research methodologies they employ. This paper critically reviews existing research to offer current insights, research gaps and potential future research directions on social media and architecture/design-related disciplines in the built environment.
Impact of supply chain quality management practices on supply chain resilience: a dynamic capability perspective
Authors: Pu Guoli , Gao Xingwei , Qiao Jianqi 
Published: February 2025

PurposeThrough the theory of dynamic capability, this study aims to make theoretical hypotheses and empirical explorations on the relationship between supply chain quality management (SCQM) practices, dynamic supply chain capability (DSCC), supply chain resilience (SCR) and environmental dynamics.Design/methodology/approachIn this study, DSCC is used as a mediating variable in the relationship between SCQM practices and SCR. To enhance the resilience of the supply chain, the moderating effect of environmental dynamics was tested. About 426 completed questionnaires were obtained from a cohort of Chinese manufacturing enterprises, and the proposed hypotheses were tested using the structural equation model method.FindingsEmpirical evidence shows that SCQM practices have a significantly positive impact on SCR at the overall level. Achieving better DSCC plays an important mediating role between SCQM practices and resilience. In addition, environmental dynamics have a moderating effect on the relationship between SCQM practices and DSCC.Originality/valueThis study constructs the influencing mechanism of SCQM practices on SCR through dynamic capability theory and enriches the relevant literature on SCR research. This study also provides management guidance for firms to enhance SCR through SCQM practices in an uncertain environment.
Social sector growth and disaster response management: the case of the Food Bank of Morocco
Authors: Al Arkoubi Khadija , Tahari Fadoua 
Published: February 2025

Learning outcomes
After completion of the case study, students will be able to analyze disaster response mechanisms and the strategic decision-making process in high-pressure environments; assess the intricacies of cross-sector partnerships and their impact on effective disaster response; provide recommendations for leaders of nongovernmental organizations (NGOs) on how to achieve sustainable growth without jeopardizing an agile disaster response; evaluate the role of an NGO in influencing policy, advocating for vulnerable communities and driving systemic change; and craft an innovative strategy for an NGO to enhance its agility and social impact.

Case overview/synopsis
This case study outlines the transformative journey of the Food Bank of Morocco (FBM), an NGO established in 2002, focusing on eradicating hunger, extending aid during natural disasters and improving education quality in impoverished, remote areas. Under the leadership of executive director Sanae Bennesser Alaoui, who joined in 2014, FBM doubled its outreach, addressing both hunger and the broader needs of communities in crisis. The narrative captures the organization’s rapid mobilization and impactful response to the COVID-19 pandemic lockdown and the September 8, 2023, Al Haouz earthquake in Morocco, reflecting its agility and the trust it garnered from the community and diaspora. Highlighting its evolution, the case study details the FBM’s strategic partnerships, innovative aid distribution and commitment to Sustainable Development Goals, emphasizing gender equality and education quality. It also underlines how FBM gained trust from the community and the global diaspora, setting a foundation for future expansion and enhanced support mechanisms for those in need. FBM’s successes include its designation as a public utility organization in 2022, which opened the door to larger contributions and greater visibility. However, the organization faced ongoing challenges in securing sustainable funding and expanding its volunteer base to maintain its growing impact. As FBM navigated these hurdles, it continued to innovate and build partnerships to support its mission of fostering sustainable growth while responding to an emerging market most pressing humanitarian needs.

Complexity academic level
This case study is suitable for senior undergraduate and graduate levels.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS7: Management Science.
Manufacturer’s modularity and operation performance: the role of digital embeddedness and organization compatibility
Authors: Rong Kuizhen , Liu Ruhong 
Published: February 2025

PurposeThis study aims to explore whether organization modularity affects the operation performance of manufacturing firms through the mediator of digital embeddedness and the moderator of organization compatibility.Design/methodology/approachHierarchical regression, mediation effect test macro and bootstrap were conducted to empirically analyze two waves of longitudinal survey data from 284 Chinese manufacturing firms.FindingsDigital embeddedness (digital technology, digital infrastructure and digital culture) mediates the relationship between organization modularity and operation performance. In addition, organization compatibility positively moderates the relationship between the three types of digital embeddedness and operation performance. Under a high organization compatibility degree, digital embeddedness has a positive impact on operational performance, but under a low organization compatibility degree, its impact is negative.Practical implicationsOrganizational modularity is an important measure for manufacturers to gain competitive advantages, especially in the industrial transformation driven by the digital economy. Manufacturers need to realize modularity immediately and consider the compatibility of digitalization so that they can embed digital technology more flexibly and adaptively and gain operational advantages.Originality/valueThis study is very relevant for industrial manufacturers, as they urgently need to know how to gain competitive advantages through organizational change in digital transformation. This study provides many reliable theoretical guidelines. Specifically, this study tells manufacturers how to better realize digital embedding and performance through modularity and how to improve the compatibility between digitalization and organization.
A re-examination of socially oriented responsibility and the cost of equity: evidence from an inflationary economy
Authors: Arianpoor Arash 
Published: February 2025

Purpose
This study aims to investigate the impact of socially oriented responsibility (SOR) (i.e. social, environmental, ethical and governance) on the cost of equity in the firms listed on the Tehran Stock Exchange.

Design/methodology/approach
The industry-adjusted earnings price ratio (IndEP) was used to evaluate the cost of equity. The cost of equity is calculated for those industries that, except firm i (with a positive profitability), have at least five other firms with a positive profitability in the industry. Hence, 79 firms were selected among seven industries from 2012 to 2022 for hypothesis testing. Gordon’s growth model was used to evaluate the cost of equity and assess the robustness of the findings. The information about 183 companies was retrieved for analysis based on Gordon’s growth model.

Findings
The results showed that SOR positively affects firms’ cost of equity. Besides, testing the details also showed that social practices (SO), environmental practices (EN), governance practices (GO) and ethical practices (ET) have a positive impact on the cost of equity. The robustness of results supported the main inferences.

Originality/value
Iran’s economic environment and capital market have been open to discussion within the global community. It is important to note that the relationship between SOR and the cost of equity in developed markets cannot be easily applied to developing Asian markets. Therefore, the present findings, along with the challenges faced in a developing Islamic economy, can contribute to informed decision-making on a global scale.
Key factors influencing the guest loyalty towards green hotels in an island sun and beach destination
Authors: Jacob Marta , Martínez-Gómez Mónica , Florido Carmen , Vives Aldric 
Published: February 2025

PurposeA study was conducted in Gran Canaria to analyse the driving factors that lead to higher loyalty amongst tourists staying in green hotels.Design/methodology/approachA conceptual model was designed to assess whether circular preferences and behaviour amongst guests (at home/in the hotel) and a hotel’s environmental policy affect guest loyalty to green hotels. A survey in hotels collected 211 responses. A new conceptualisation of the loyalty to green hotels construct was defined.FindingsThe model detects key success predictors and connects them to different measures to improve performance in terms of circular hotel practices. This paper identifies tourist segments with more pro-circular behaviour and the highest loyalty levels to green hotels and uses a multi-group analysis by partial least squares to assess the moderation of control variables for the proposed theoretical model, identifying segments with more pro-circular behaviour and loyalty levels to green hotels.Practical implicationsThis study determines tourism segments with higher loyalty to green hotels by analysing commitment levels across market segments. The findings help eco-friendly hotels design plans to attract and retain guests that are environmentally aware and evaluate their acceptance of circular behaviour. Insights also support revenue strategies to encourage repeat business.Originality/valueThe study enhances research on tourists’ circular behaviour by focusing on island destinations, bridging a gap from continental studies. It highlights 3R-based practices, explores factors like gender, age, booking channel, board and traveller type that influence pro-circular behaviour and offers insights for destination management organizations and hotel marketers to attract long-term sustainable demand.
Fostering social entrepreneurship through social capital approach: an empirical study in China
Authors: Ng Peggy M.L. , Lit Kam Kong , Chan Jason K.Y. , Cheung Cherry Tin Yan , Choy Ellesmere T.K. 
Published: February 2025

PurposeThe purpose of this paper is to examine the underlying mechanisms influencing the social entrepreneurial intentions of individuals in China, adopting social capital theory, bottom-up and people-based approach. The interrelated effects of intellectual capital (social community trust, social capital bonding and social participation) on social innovation tendency were measured.Design/methodology/approachWe recruited 502 Chinese individuals by utilising a reliable survey platform in China. This study used structural equation modelling as an analytical approach to examine the influence of social capital on social innovation and social entrepreneurship intention.FindingsThe findings showed that social innovation tendencies mediate the relationship between social community trust, social capital bonding and social participation and the social entrepreneurial intentions of individuals. The findings support the tested hypotheses that social innovation tendencies are the key mechanism to translate into stronger social entrepreneurial intentions. An iterative framework emphasising transparency and open collaboration among stakeholders, which are vital for fostering social entrepreneurial intentions, was proposed.Originality/valueThis is a novel empirical study to apply social capital theory to the field of social enterprises in the Chinese context using structural equation modelling, bottom-up, people-based approach and iterative model. The findings offer valuable practical insights for entrepreneurial and SME practices to foster social entrepreneurship through a people-based approach, emphasising the importance of fostering trust, strengthening social bonds, and encouraging active social participation.