bluuebunny/crossref_metadata_2025_split huggingface dataset:
An unexpected product during synthesis of 3‐phenylisoquinoline: Improved preparation of 4‐hydroxy‐3‐phenylisoquinoline
Authors: Sard Howard 
Published: March 2009

AbstractDuring repetition of the Bradsher procedure for the preparation of 3‐phenylisoquinoline (1) an unexpected by‐product was isolated, 4‐hydroxy‐3‐phenylisoquinoline (3). This product is likely formed via allylic oxidation of a 1,4‐dihydroisoquinoline intermediate. By minor modification of the reaction conditions, 3 can be obtained in up to 50% yield. This represents a much improved method for the preparation of 3, as compared with previously reported syntheses.
Preparation of 3‐bromo‐2‐methylfuran and 4‐bromo‐2‐methylfuran
Authors: Koyanagi Jyunichi , Yamamoto Katsumi , Nakayama Kouji , Tanaka Akira 
Published: March 2009

Abstract4‐endo‐5‐exo‐Dibromo‐3‐methyl‐3,6‐endo‐oxyperhydrophthalic anhydride 3b and 4‐exo‐5‐endo‐dibro‐mo‐3‐methyl‐3,6‐endo‐oxyperhydrophtbalic anhydride 3c were isolated from the bromo‐adducts of 3‐methyl‐3,6‐endo‐oxy‐1,2,3,6‐tetrahydrophthalic anhydride 2. When 3b or 3c was heated in quinoline, only 3‐bromo‐2‐methylfuran 4 was obtained from 3b and only 4‐bromo‐2‐methylfuran 5 from 3c.
Haloacetylated enol ethers: 4 [6]. Synthesis of 4‐trihalomethyl‐2‐methylthiopyrimidines
Authors: Madruga Claudia Da C. , Clerici EdÍLia , Marcos A. P. 
Published: March 2009

AbstractThe synthesis of a series of 5‐ and 6‐substituted 4‐trihalomethyl‐2‐methylthiopyrimidines, prepared from the cyclocondensation reaction of β‐alkoxyvinyl tri[fluoro]chloromethyl ketones with 2‐methyl‐2‐thiopseudourea sulfate, are reported. A systematic study to find the best reaction conditions were carried out.
Hydrolysis of 4‐cyano‐1‐ethoxypyrimido[1,6‐a]benzimidazole: Formation of a ynaminonitrile and benzimidazolidines
Authors: Zama Yoshimi , Okamoto Yoshibisa , Takagi Kaname , Kurasawa Yoshihisa , Takada Atsushi 
Published: March 2009

AbstractThe title compound 4 was hydrolyzed to a new type of ynaminonitrile 5 and benzimidazolidines 7 and 9 under acidic or basic conditions. Reaction mechanisms were proposed.
Synthesis of 2‐aryl‐3‐trifluoromethylsulfonylpyrroles
Authors: Barnes Keith D. , Ward Randall 
Published: March 2009

AbstractA general method for the preparation of 2‐aryl‐3‐trifluoromethylsulfonylpyrroles 2 has been developed. Procedures for the construction of the key enamine intermediates 9 and their cyclizations to pyrroles are reported.
Cyclic imides. 16. Hydroxy and methoxy derivatives of aminophthalimide and phthalhydrazide
Authors: Caswell Lyman R. , Cavasos Gayle 
Published: March 2009

AbstractTreatment of N‐alkyl derivatives of 3,6‐dichlorophthalimide and 4,5‐dichlorophthalimide with potassium nitrite gave 3‐hydroxy‐6‐nitro‐ and 4‐hydroxy‐5‐nitrophthalimides. The potassium salts of these phenols were alkylated by dialkyl sulfates. The products were reduced to the 3‐amino‐6‐alkoxy‐ and 4‐amino‐5‐alkoxyphthalimides, and the fluorescence emission spectra of these products were measured. Hydrazinolysis of the phthalimides in a toluene medium gave phthalhydrazides. The luminescence spectra of several aminophthalhydrazides were measured. The infrared and proton magnetic resonance spectra of these and of some nitrophthalhydrazides were measured and aspects of these spectra characteristic of phthalhydrazides were identified.
Polyfunctional pyridines from nitroacetamidine and β‐diketones. A useful synthesis of substituted imidazo [4,5‐b] pyridines and related compounds
Authors: Batt Douglas G. , Houghton Gregory C. 
Published: March 2009

AbstractNitroacetamidine undergoes a useful cyclocondensation with β‐diketones to produce substituted 2‐amino‐3‐nitropyridines. Use of an acylpyruvate generates hitherto unreported 2‐amino‐3‐nitropyridine‐4‐carboxylates. These may be converted easily to functionalized imidazo[4,5‐b]pyridines and oxazolo‐[5,4‐b]pyridines.
Ring transformations of heterocyclic compounds. XI. 2,4,6‐triarylphenylquinolinium salts from methyl substituted derivatives via (thio)pyrylium ring transformations
Authors: Zimmermann Thomas 
Published: March 2009

AbstractThe preparation of hitherto unknown 2,4,6‐triarylphenyl substituted quinolinium perchlorates 3 from methylquinolinium derivatives 2 by a 2,6‐[C5+C] ring transformation of 2,4,6‐triaryl(thio)pyrylium salts 1/4 in the presence of triethylamine/acetic acid is described. Spectroscopic data of the quinolinium perchlorates 3 and their formation via anhydrobases of the salts 2 are discussed.
Molecular modeling, NMR spectroscopy, and conformational analysis of 3′,4′‐anhydrovinblastine
Authors: Andrews C. Webb , Wisowaty James , Davis Ann O. , Crouch Ronald C. , Martin Gary E. 
Published: March 2009

AbstractThe assignment of the proton spectrum of 3′,4′‐anhydrovinblastine is reported. Assignments are made for several protons for which only approximate assignments were available previously. Homonuclear TOCSY and ROESY spectra were utilized in conjunction with HMQC and HMBC spectra in making the assignment. Correlations in the ROESY spectrum suggested a preferred conformation of the cleavamine (upper) portion of 3′,4′‐anhydrovinblastine in which the 21‐methyl of the 20/21 ethyl group of the vindo‐line (lower) portion is in proximity to the H14′ and 16′‐NH resonances of the cleavamine. In a Monte Carlo search, the global minimal energy structure was oriented with the 16‐methoxyl group oriented toward the H14′ and 16′‐NII resonances. Two other structures, the second and tenth lowest in energy, 0,2 kJ and 8 kJ higher in energy, respectively, brought the 21‐methyl group in proximity to the H14′ and 16′‐NH resonances in a fashion consistent with the ROESY data. The preferred solution conformation of 3′,4′‐anhy‐drovinblastine is consistent with the reported solution conformation of vinblastine.
Total 1H and 13C chemical shift assignment of indolizino[3,4,5‐a,b]‐isoindole and 2‐methylthiobenz[f]imidazo[5,1,2‐c,d]indolizine
Authors: Castle Lyle W. , Tominaga Yoshinori , Castle Raymond N. 
Published: March 2009

AbstractThe 1H and 13C nmr spectral assignment of indolizino[3,4,5‐a,b]isoindole and 2‐methylthiobenz[f]‐imidazo[5,1,2‐c,d]indolizine are described. A concerted interpretation of the HMQC, HMQC‐TOCSY, HMBC and nOe‐difference experiments were used to assign the 1H and 13C resonances of indolizino‐[3,4,5‐a,b]isoindole, whereas for 2‐methylthiobenz[f]imidazo[5,1,2‐c,d]indolizine a concerted interpretation of the COSY, HMQC and HMBC experiments were used to generate spectral assignments.
Synthesis of certain alkenyl purines and purine analogs
Authors: Sudhakar Rao T. , Revankar Ganapathi R. 
Published: March 2009

AbstractSynthesis of alkenyl derivatives of certain purines and purine analogs is described. Direct alkylation of the sodium salt of 6‐chloropurine (1) either with 1‐bromo‐2‐pentene or 4‐bromo‐2‐methyl‐2‐butene in N,N‐dimethylformamide furnished N‐7, 4a and N‐9, 3a, 3b alkenyl derivatives. Similar alkylation of 2‐amino‐6‐chloropurine (2) provided the corresponding N‐7, 4c‐4e and N‐9, 3c‐3e alkenyl derivatives. Acid hydrolysis of these chloro derivatives 3a‐3e, 4a,c‐e furnished the corresponding alkenyl hypoxan‐thines 6a, 6b and 7a or alkenyl guanines 6c‐6e and 7c‐7e. Treatment of 3a‐3d with thiourea in absolute ethanol provided the corresponding 6‐thio derivatives 5a‐5d. Alkylation of the sodium salt of either purine‐6‐carboxamide (8) or 1,2,4‐triazole‐3‐carboxamide (10) gave mainly one isomer 9a, 9b and 11a, 11b. The direct alkylation of pyrrolo[2,3‐d]pyrimidin‐4(3H)‐one (12) gave N‐3 alkenyl derivatives 13a, 13b, and the N‐7 alkenyl derivatives 16a, 16b have been prepared starting from the 4‐chloro derivative 14. Synthesis of 2‐amino‐7‐(2‐penten‐1‐yl)pyrrolo[2,3‐d]pyrimidin‐4(3H)‐one (19a) has been accomplished starting from 2‐amino‐4‐methoxypyrrolo[2,3‐d]pyrimidine (17). These alkenyl derivatives were found to be devoid of anti‐HCMV activity in vitro.
On the formation of estrone lactam esters of N,N‐bis(2‐chloroethyl)aminocinnamic acid isomers, p‐N,N‐bis(2‐chloroethyl)aminophenylbutyric acid and their antitumor activity
Authors: Catsoulacos P. , Pairas G. , Papageorgiou A. 
Published: March 2009

AbstractNew estrone‐lactam esters, 17α‐aza‐D‐homo‐Δ1,3,5(10)‐estratrien‐3‐ol‐17‐one‐N,N‐bis(2‐chloroethyl)‐aminocinnamic isomers and p‐N,N‐bis(2‐chloroethyl)aminophenylbutyrate have been synthesized and tested in P388 leukemia in vivo and P388 and L1210 leukemias in vitro. The effect of these compounds on SCE rates and on cell kinetics in cultured human lymphocytes was studied also.
Synthesis and characterization of 4‐hydroxy‐3‐phenylprolines
Authors: Sacchi Antonia , De Caprariis Paolo , Mayol Luciano , De Martino Giovanni 
Published: March 2009

Abstract4‐Hydroxy‐3‐phenylprolines were synthesized via 1‐acetyl‐2,2‐diethoxycarbonyl‐2,3‐dihydro‐3‐phenyl‐1H‐pyrrole. Reversed phase hplc resulted in the isolation of the products which were characterized by 1H and 13C nmr spectroscopy.
Two new indoloquinoline alkaloids from cryptolepis sanguinolenta: Cryptosanguinolentine and cryptotackieine
Authors: Sharaf Maged H. M. , Schiff Paul L. , Tackie Albert N. , Phoebe Charles H. , Martin Gary E. 
Published: March 2009

AbstractThe roots of the indigenous West African shrub Cryptolepis sanguinolenta have proved to be a rich source of indoloquinoline alkaloids. To date, all of the alkaloids isolated have been analogs of indolo[3, 2‐b]quinoline. We now wish to report examples of two new indoloquinoline alkaloids which differ in the fusion of the indole and quinoline rings. The first, cryptosanguinolentine, is an angular indolo[3, 2‐c]quinoline. The second, cryptotackieine, is a linear indolo[2, 3‐b]quinoline system. Both of these families of alkaloids are without precedent from C. sanguinolenta. The structures of both were established through the extensive use of inverse‐detected micro nmr methods.
Hydroxide‐promoted redox reactions in water of α‐Phenyl‐4‐nitro‐benzenemethanol, α‐(p‐Nitrophenyl)‐4‐pyridinemethanol, and α‐(p‐Nitrophenyl)‐4‐Pyridinemethanol N‐Oxide steric inhibition of resonance
Authors: Muth Chester W. , Yang Kaipeen E. 
Published: March 2009

Abstractα‐Phenyl‐4‐nitrobenzenemethanol (3) reacted with 1 M sodium hydroxide to yield 4, 4′‐dibenzoyl‐azoybenzene (5) (51%), 4‐hydroxy‐4′‐benzoylazobenzene (6) and benzoic acid (12% each), and smaller amounts of 4‐aminobenzophenone and 4‐nitrobenzophenone. Both α‐phenyl‐2‐nitrobenzenemethanol (9) and 3, 5‐dimethyl‐4‐nitrobenzenemethanol (10a) did not react with 1 M sodium hydroxide, presumably due to steric hindrance. α‐(p‐Nitrophenyl)‐4‐pyridinemethanol (14) and its N‐oxide 11 with 1 M sodium hydroxide yielded 4,4′‐diaroylazoxybenzenes 15a and 12a, respectively, 4,4′‐diaroylazobenzenes 15b and 12b, respectively, as well as 4‐hydroxy‐4′‐aroylazobenzenes 16 and 13, respectively. The relative reaction rates were 11 > 14 > 3. Studies with 11 showed that the nitro group is involved in the redox reaction in preference to the N‐oxide group.
Reactions of 1‐aryl‐2,2,2‐trifluoroethanone oximes with tetrasulfur tetranitride: Novel synthesis of 5‐aryl‐5‐trifluoromethyl‐4H‐1,3,2,4,6‐dithiatriazines and 1‐aryl‐2,2,2‐trifluoro‐ethanonylidenaminosulfenamides
Authors: Kim Kil‐Joong , Lee Hyi‐Seung , Kim Kyongtae 
Published: March 2009

AbstractThe reactions of 1‐aryl‐2,2,2‐trifluoroethanone oximes with tetrasulfur tetranitride (S4N4) in toluene at reflux gave 5‐aryl‐5‐trifluoromethyl‐4H‐1,3,2,4,6‐dithiatriazines 2, 1‐aryl‐2,2,2‐trifluoroethanonyliden‐aminosulfenamides 3 and sulfur in 0–37%, 7–53%, and 2–41% yields, respectively. Treatment of 2 with tributyltin hydride in the presence of azobisisobutyronitrile in benzene at 80° afforded 3 in excellent yields.
Syntheses of 8‐aminoimidazo[4′,5′:5,6]pyrido[2,3‐d]pyrimiciines: Linear tricyclic analogs of adenine
Authors: Harris Philip A. , Pendergast William 
Published: March 2009

AbstractThe syntheses of 8‐aminoimidazo[4′,5′:5,6]pyrido[2,3‐d]pyrimidines (7), stretched‐out versions of the naturally occuring nucleoside base adenine, are reported. Their preparation involves conversion of purine into 5‐arninoimidazo[4,5‐b]pyrimidine‐6‐carbonitrile (1) by reaction with malononitrile, followed by construction of the pyrimidine ring in two stepsviathe ethoxymethylene derivative3. 8‐Azapurine can be converted to 8‐amino‐1,2,3‐triazolo[4′,5′:5,6]pyrido[2,3‐d]pyrimidines8in a similar fashion.
1‐(Azidomethyl)benzotriazole and ‐5‐phenyl‐1,2,3,4‐tetrazole as 1, 3‐dipolar cycloaddition components
Authors: Katritzky Alan R. , Fali Clara N. , Shcherbakova Irina V. , Verin Sergei V. 
Published: March 2009

Abstract1‐(Azidomethyl)benzotriazole reacts with alkynes to give mixtures of isomeric 1,2,3‐triazoles, whereas the interactions of 1‐(azidomethyl)benzotriazole and ‐5‐phenyl‐1,2,3,4‐tetrazole with alkenes proceed regioselectively to form 1,2,3‐triazolines and/or aziridines and enamines in good yields. Diheterocyclosubstituted methanes thus obtained were investigated with respect to thermolysis, α‐lithiation, and reactions with Grignard reagents.
1,6‐ and 1,7‐naphthyridines. I. Rearrangement of quinolinimidoacetic acid derivatives
Authors: Blanco Mercedes , Lorenzo M. Gabriela , Perillo Isabel , Schapira Celia B. 
Published: March 2009

AbstractThe reaction of N‐substituted quinolinimides 1a‐d with sodium alkoxides afforded a mixture of 1,6‐naphthyridines 2 and 1,7‐naphthyridines 3 which were isolated by chromatographic methods. Structure assignment for each pair of isomers was made by comparison of their 1H nmr spectra with those of picolinamide and nicotinamide. When esters 1a‐c were treated with alkoxides from primary alcohols, other than that of the ester, total transesterification took place. Experimental results suggest that transesterification occurs in open intermediary species.
Nitration of sydnones. Reaction with 3‐Arylsydnones containing electron‐donors on the aryl ring
Authors: Turnbull Kenneth , Blackburn Thomas L. , Miller John J. 
Published: March 2009

AbstractExclusive aryl ring nitration of a series of 3‐arylsydnones 1 with electron donors (di‐ or tri‐methyl) on the aryl ring is reported.
Fused heterocycles. 8. An efficient procedure for the stereoselective synthesis of trans‐2,3,3a,4‐tetrahydro‐3‐aryl‐2‐phenyl[1]benzopyrano[4,3‐c]pyrazoles and their [1]benzothiopyrano analogues
Authors: Lévai Albert 
Published: March 2009

AbstractStereoselective synthesis of trans‐2,3,3a,4‐tetrahydro‐3‐aryl‐2‐phenyl[1]benzopyrano[4,3‐c]pyrazoles 13–18 and their [1]benzothiopyrano analogues 19–24 has been performed by the reaction of 3‐arylidenechromanones 1–6 and 3‐arylidene‐1‐thiochromanones 7–12 with phenylhydrazine in hot pyridine. The structure and stereochemistry of the compounds prepared have been elucidated by ir, lH and 13C nmr measurements.
Syntheses of new pyridonecarboxylic acid derivatives containing 1‐ or 2‐naphthyl substituents at n‐1 and their anti‐hiv‐rt activities
Authors: Oh Yoon‐Seok , Cho Sung‐Hye 
Published: March 2009

AbstractA series of new pyridonecarboxylic acid derivatives containing 1‐ or 2‐naphthyl substituents at N‐1 were synthesized and their in vitro anti‐HIV‐RT activities were evaluated. Several compounds in this series showed better activity than Atevirdine.
Synthesis and studies on spectral behaviour and molecular dynamics of 7‐Aryl‐4,5‐Dihydro‐2‐Oxo‐3H,8H‐Furo[3,4‐b] [1,4]diazepines
Authors: Zimmer Hans , Nauss Jeffrey L. , Amer Adel 
Published: March 2009

AbstractA new series of 7‐aryl‐4,5‐dmydro‐2‐oxo‐3H,8H‐furo[3,4‐b][1,4] diazepines were prepared. Their lH nmr spectra have been interpreted in terms of the interconversion of two pseudo‐boat conformers. Molecular‐dynamics simulations at different temperatures on this type of compounds revealed a very small energy difference between these two conformers.
Resolution of four k‐region arene imines and mutagenicity of the optically pure aziridines
Authors: Blum Jochanan , Cohen Yaron , Levin Shulamit , Katschak Andrea , Glatt Hansruedi 
Published: March 2009

AbstractRacemic K‐region imines of benz[a]anthracene, 7‐methylbenz[a]anthracene, chrysene and benzo[a]pyrene (1–4, respectively) have been resolved by high performance liquid chromatography on a column packed with amylose tris(3,5‐dimethylphenylcarbamate) on silica gel. The absolute configuration of the resolved aziridines was assigned by comparison of their circular dichromism spectra to those of the corresponding enantiomerically pure arene oxides. The mutagenicity of the enantiomers of the arene imines was investigated using Salmonella typhimurium strains TA98 and TA100. Although all arene imines investigated were potent mutagens, quantitative and qualitative differences in the mutagenic activity were observed between enantiomers.
Iminium carbonic acid derivative salts. XII. electrophilic reactions of 2‐methylthio‐4,5‐dihydrothiazolium iodides, 5‐methyl‐2‐methylthiothiazolium iodides and 2‐methylthio‐5,6‐dihydro‐1,3‐thiazinium iodides. part III. With Vinylogous and Phenylogous Active Methylene Compounds
Authors: Hanefeld Wolfgang , Harms Helge 
Published: March 2009

Abstract3‐Benzyl‐2‐memyltmo‐4,5‐dmydrothiazolium iodide (1), 5‐metlyl‐2‐methylthio‐3‐phenethylthiazolium iodide (4) and 3‐methyl and 3‐benzyl‐2‐methylthio‐5,6‐dihydro‐1,3‐thiazinium iodides 7a, b were reacted with the vinylogous doubly activated CH‐acidic compounds 2a‐d and the phenylogous doubly activated components 8, 11, 16, 19 and 21 to yield new types of S, N‐heterocycles 3, 5, 6, 9, 10, 12, 13, 14, 15 with the partial structure of push‐pull substituted butadienes and 17, 18, 20, 22, 23 and 24 with the character of push‐pull substituted phenyl ketene S, N‐acetals.
Synthesis of pyrazolo[1,5‐a]pyrimidines in the reaction of 5‐amino‐3‐arylpyrazoles with methoxymethylene meldrum's acid derivatives and thermolysis of their pyrazolylaminomethylene derivatives
Authors: Quiroga Jairo , Hormaza Angelina , Insuasty Braulio , Saitz Claudio , Cañete Alvaro , Jullian Carolina 
Published: March 2009

AbstractA series of pyrazolo[1,5‐a]pyrimidin‐3‐ones 3 was prepared from Meldrum's acid and 5‐amino‐3‐arylpyrazoles 1 by cyclization in nitrobenzene of the corresponding 5‐pyrazolylaminomethylene Meldrum's acid derivatives 2. The structure of pyrazolo[1,5‐a]pyrimidin‐3‐ones and their precursors were determined by nmr measurements.
Synthesis of some azeto[2,1‐a]isoquinolin‐2‐ones
Authors: Cho Su‐Dong , Kim Sung‐Kyu , Yoon Yong‐Jin 
Published: March 2009

AbstractSome azeto[2,1‐a]isoquinolin‐2‐ones were synthesized from 2‐(3,4‐dimethoxyphenyl)ethylamine in three steps in good yield.
The synthesis of some pyrano[2,3‐g]chromene‐2,7‐diones and furo[2,3‐g]chromen‐6‐ones
Authors: Nicolaides D. N. , Fylaktakidou K. C. , Litinas K. E. , Adamopoulos S. G. 
Published: March 2009

AbstractThe o‐hydroxyformylcoumarin 5b, easily prepared from compound 1, is further transformed to the title coumarin derivatives 7, 10, 19a‐c via its initial Wittig olefination with ylides 2b, 8, 18a‐c respectively. Coumarins 16a, b were also formed by treatment of 5b with compounds 15a, b. The preparation of the interesting furocoumarin derivatives 11, 14, 20b, c as well as of compound 13 is also described.
1,6‐π‐Electrocyclization of 3‐Vinyl‐Functionalized N,N‐Dimethyl‐2,2′‐Bisindolyl: Some analysis of the educt transformation process
Authors: Pindur U. , Kim Y.‐S. 
Published: March 2009

AbstractThe thermally and photochemically induced 1,6‐π‐electrocyclization reaction of 3‐vinyl‐functionalized N, N'‐dimethyl‐2,2′‐bisindolyls 4 has been analysed and some reactivity aspects are presented. On the basis of time dependent 1H nmr and uv spectroscopic measurements the educt transformations can be observed in detail. Some results of the isomerization process of the educts are also given.
Acylation of a novel quinoxalinyl substituted pyrazole derivative. synthesis, quantum chemistry calculations, and x‐ray structure analysis
Authors: Matuszczak Barbara , Langer Thierry , Mereiter Kurt 
Published: March 2009

AbstractThe preparation of N‐acetylpyrazolyl‐quinoxalines and results of semiempirical MO calculations are presented. The structure determination of the isomers 3a, b was achieved by X‐ray analysis.
Synthesis of new 2H,4H‐benzopyrano[3,4‐b]yridine‐1,3,5‐trione derivatives via carbon suboxide
Authors: Bonsignore Leonardo , Loy Giuseppe 
Published: March 2009

AbstractThe new 2H,4H‐[1]benzopyrano[3,4‐b]pyridine‐1,3,5‐trione derivatives 10a‐f were prepared in the following three steps: first the preparation of new N‐(tert‐butoxycarbonyl)‐3‐amino‐2H‐1‐benzopyran‐2‐one derivatives 5a‐f by reaction of coumarin‐3‐carboxylic acids and diphenylphosphorylazide, then hydrolysis of 5a‐f with gaseous hydrogen chloride to give the corresponding amines 7a‐f, and finally the preparation of 10a‐f by reaction of 7a‐f and carbon suboxide in the presence of a Lewis acid.
Synthesis and unexpected reactions of 2‐Hydroxy‐3‐pyridinylacetic hydrazides. Formation of 2H‐Pyrrolo[2,3‐b]pyridin‐2‐ones
Authors: Teleha Christopher A. , Greenberg Roger A. , Chorvat Robert J. 
Published: March 2009

AbstractTreatment of 2‐hydroxy‐3‐pyridinylacetic hydrazides under mild mesylation conditions provided 2H‐pyrrolo[2,3‐b]pyridin‐2‐ones as unexpected products. This rearrangement is believed to result from an intramolecular attack of the hydrazide on a reactive pyridinium species formed under the reaction conditions.
Synthesis and structure of dinitroazofurazan
Authors: Zelenin Alexander K. , Trudell Mark L. , Gilardi Richard D. 
Published: March 2009

AbstractThe synthesis of dinitroazofurazan (3) was achieved from readily available diaminofurazan (6) in two steps and 20% overall yield. The structure of the energetic material 3 was unequivocally confirmed by X‐ray crystallography and found to have a crystal density of 1.742 g/cm3.
Structure elucidation and 13c NMR assignment of an 1,2,4‐oxadiazole substituted pyrazole
Authors: Neidlein Richard , Kramer Walter , Li Sheng 
Published: March 2009

AbstractThe orientation of the substituent groups in an 1,2,4‐oxadiazole substituted pyrazole, formed by reaction of a phenylnitrile oxide with an unsymmetrically substituted hydrazine is determined. One‐dimensional methods as the selective INEPT and 13C{1H} nOe experiments are used. Both techniques provide also an unambiguous assignment of the 13C nmr spectrum.
Synthesis of thiazole‐containing benzo‐crown ethers
Authors: Kim Hong‐Seok , Koh Young Kook , Choi Jun‐Hyeak 
Published: March 2009

AbstractA series of benzo‐crown ethers containing the thiazole subcyclic moity have been synthesized. Reaction of 1,2‐bis(thioamidomethyloxy)benzene 2 with ethyl bromopyruvate in ethanol provided 1,2‐bis(thiazolyl)benzene 4 (80%) along with thiazole 5 (14%). Reduction of 4 with lithium aluminum hydride followed by mesylationbromination gave 7. Similar treatment of 5 with lithium aluminum hydride followed by bromination resulted in 12. Benzo‐crown ethers 8, 9, 10, and 13 were prepared from the reactions of 4‐bromomethylthiazole derivatives 7 and 12 with catechol and resorcinol derivatives in the presence of potassium hydride.
4‐Methyl‐3,4‐dihydrospiro[cycloheptane‐1′,2(1H)‐quinoline] and 4‐methyl‐3,4‐dihydrospiro[cyclooctane‐1′,2(1H)‐quinoline]. synthesis of derivatives and chemical transformations
Authors: Palma Alirio , Rozo Wilson , Stashenko Elena , Molina Daniel , Kouznetsov Vladimir 
Published: March 2009

AbstractNew derivatives of 3,4‐dihydrospiro[cycloalkane‐1′,2(1H)‐quinolines] were obtained from cycloheptanone and cyclooctanone via facile three steps hetero spiro annulation process. Their nitro derivatives were prepared through electrophilic substitution reactions.