bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Ayurveda-based lifestyle modification, diet, and panchakarma on the hemodynamic parameters in heart failure patients with preserved ejection fraction
Authors: Rohit, Sane , Rahul Mandole , Gurudatta Amin , Tejashree Jadhav , Prafull Yashwantrao , Snehal Dongre , Swapanil Srivastav , Vaibhav Singh 
Published: April 2024

Abstract

Background:
Heart failure (HF) with preserved ejection fraction (HFpEF) is a medical problem with a growing prevalence that requires sophisticated management techniques. New management strategies for HF have constantly been called for by researchers, which has drawn our attention to Ayurveda, the traditional alternative medicine practiced extensively in India. One such treatment used to treat heart failure is Heart Failure Reversal Therapy (HFRT), which combines herbal therapies including Snehan, Swedan, Basti (per rectal drug administration), and Hridaydhara.

Objective:
The study is aimed to evaluate the effects of HFRT and Ayurveda Dinacharya on known chronic HFpEF patients.

Materials and Methods:
This observational study was conducted between May 2021 and October 2021, wherein patients (both genders) with HF (New York Heart Association, NYHA Class I, II, and III) having a left ventricular ejection fraction of more than 40 and aged between 18 and 60 years were identified. The effect of study therapy, HFRT, and Ayurveda Dinacharya over 7 days in 14 sittings was observed. A total of 73 patients with HFpEF underwent study therapy for 7 days. Data related to patient demographics on Cardiac Output (CO), Diastolic Blood Pressure (DBP), Heart Rate (HR), Left Ventricular (LV), Systolic Blood Pressure (SBP), Systemic Vascular Resistance (SVR), Systolic (SYS), End-diastolic volume (EDV), Ejection factor (EF), etc. were analyzed pre- and post-study.

Results:
There was a remarkable improvement in the mean values of SVR from day 1 to day 7. The mean value of SVR on day 1 was 2271.39 ± 509.66, and on day 7 was 1876.18 ± 315.21. Reduced SVR values mean the amount of LV force needed to open the aortic valve is also reduced. This causes more efficient pumping action in the left ventricle, reflected by increased CO and increased VO2 max, thus improving the quality of life.

Conclusion:
The HFRT therapy and Ayurveda Dinacharya for seven days demonstrated a significant change in the hemodynamics of HFpEF patients, thus improving the quality of life.
Imaging Role in Diagnosis, Prognosis, and Treatment Response Prediction Associated with High-grade Glioma
Authors: Heidari Maryam , Shokrani Parvaneh 
Published: April 2024

Abstract

Background:
Glioma is one of the most drug and radiation-resistant tumors. Gliomas suffer from inter- and intratumor heterogeneity which makes the outcome of similar treatment protocols vary from patient to patient. This article is aimed to overview the potential imaging markers for individual diagnosis, prognosis, and treatment response prediction in malignant glioma. Furthermore, the correlation between imaging findings and biological and clinical information of glioma patients is reviewed.

Materials and Methods:
The search strategy in this study is to select related studies from scientific websites such as PubMed, Scopus, Google Scholar, and Web of Science published until 2022. It comprised a combination of keywords such as Biomarkers, Diagnosis, Prognosis, Imaging techniques, and malignant glioma, according to Medical Subject Headings.

Results:
Some imaging parameters that are effective in glioma management include: ADC, FA, Ktrans, regional cerebral blood volume (rCBV), cerebral blood flow (CBF), ve, Cho/NAA and lactate/lipid ratios, intratumoral uptake of 18F-FET (for diagnostic application), RD, ADC, ve, vp, Ktrans, CBFT1, rCBV, tumor blood flow, Cho/NAA, lactate/lipid, MI/Cho, uptakes of 18F-FET, 11C-MET, and 18F-FLT (for prognostic and predictive application). Cerebral blood volume and Ktrans are related to molecular markers such as vascular endothelial growth factor (VEGF). Preoperative ADCmin value of GBM tumors is associated with O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status. 2-hydroxyglutarate metabolite and dynamic 18F-FDOPA positron emission tomography uptake are related to isocitrate dehydrogenase (IDH) mutations.

Conclusion:
Parameters including ADC, RD, FA, rCBV, Ktrans, vp, and uptake of 18F-FET are useful for diagnosis, prognosis, and treatment response prediction in glioma. A significant correlation between molecular markers such as VEGF, MGMT, and IDH mutations with some diffusion and perfusion imaging parameters has been identified.
Analysis of informed consent documents for compliance with ICMR guidelines for biomedical and health research
Authors: Chindhalore Chaitali Ashish , Dakhale Ganesh N. , Gajbhiye Snehalata V. , Gupta Ashish Vijay , Khapeka Shivam V. 
Published: April 2024

Abstract

Background:
Ethical conduct of research depends on the voluntary expression of consent and adequate disclosure of information about the research in informed consent documents (ICDs).

Objectives:
The objective of this study was to analyze ICDs of academic studies for compliance with National Ethical Guidelines for Biomedical and Health Research laid down by the Indian Council of Medical Research (ICMR) and to determine the readability of ICDs using the Flesch–Kincaid Grade Level scale and Flesch reading-ease (FRE) score.

Methodology:
ICDs of academic research projects submitted during 2020–22 were retrieved from the IEC office and analyzed for compliance with ICMR 2017 guidelines. The readability of the documents was assessed by the Flesch–Kincaid Grade Level Scale and FRE score.

Results:
Among 177 protocols analyzed, the most common were epidemiological studies (36.72%), followed by diagnostic studies (28.81%). Vernacular translations of ICDs were present in significantly more studies in 2022 (χ
2 = 7.18, P = 0.02) as compared to 2020 and 2021. FREs score was 45.75 ± 10.76, and Flesch–Kincaid Grade Level was 8.67 ± 1.44. Content analysis of participant information sheet (PIS) revealed that significantly more PIS submitted in 2022 mentioned expected duration of participation (χ
2 = 6.95, P < 0.001), benefit to patient/community (χ
2 = 26.63, P < 0.001), disclosure of foreseeable risk or discomfort (χ
2 = 21.72, P < 0.001), payment for participation (χ
2 = 21.72, P < 0.001), and identity of research team and contact details (χ
2 = 18.58, P < 0.001). Compliance score was significantly better in 2022 as compared to 2020 and 2021.

Conclusion:
Gradually, ICDs became more compliant with ICMR guidelines. Still, there is scope for improvement in ICDs regarding content and readability so that patients can comprehend facts easily to make informed decisions in a real sense.
Evaluating large language models for selection of statistical test for research: A pilot study
Authors: Mondal Himel , Mondal Shaikat , Mittal Prabhat 
Published: April 2024

Abstract

Background:
In contemporary research, selecting the appropriate statistical test is a critical and often challenging step. The emergence of large language models (LLMs) has offered a promising avenue for automating this process, potentially enhancing the efficiency and accuracy of statistical test selection.

Aim:
This study aimed to assess the capability of freely available LLMs – OpenAI’s ChatGPT3.5, Google Bard, Microsoft Bing Chat, and Perplexity in recommending suitable statistical tests for research, comparing their recommendations with those made by human experts.

Materials and Methods:
A total of 27 case vignettes were prepared for common research models with a question asking suitable statistical tests. The cases were formulated from previously published literature and reviewed by a human expert for their accuracy of information. The LLMs were asked the question with the case vignettes and the process was repeated with paraphrased cases. The concordance (if exactly matching the answer key) and acceptance (when not exactly matching with answer key, but can be considered suitable) were evaluated between LLM’s recommendations and those of human experts.

Results:
Among the 27 case vignettes, ChatGPT3.5-suggested statistical test had 85.19% concordance and 100% acceptance; Bard experiment had 77.78% concordance and 96.3% acceptance; Microsoft Bing Chat had 96.3% concordance and 100% acceptance; and Perplexity had 85.19% concordance and 100% acceptance. The intra-class correction coefficient of average measure among the responses of LLMs was 0.728 (95% confidence interval [CI]: 0.51–0.86), P < 0.0001. The test–retest reliability of ChatGPT was r = 0.71 (95% CI: 0.44–0.86), P < 0.0001, Bard was r = −0.22 (95% CI: −0.56–0.18), P = 0.26, Bing was r = −0.06 (95% CI: −0.44–0.33), P = 0.73, and Perplexity was r = 0.52 (95% CI: 0.16–0.75), P = 0.0059.

Conclusion:
The LLMs, namely, ChatGPT, Google Bard, Microsoft Bing, and Perplexity all showed >75% concordance in suggesting statistical tests for research case vignettes with all having acceptance of >95%. The LLMs had a moderate level of agreement among them. While not a complete replacement for human expertise, these models can serve as effective decision support systems, especially in scenarios where rapid test selection is essential.
Research on the Orientated Effective Components of Huangqi in Huangqi Jianzhong Tang Against Chronic Atrophic Gastritis Based on Multi-Spectrum–Effect Correlation
Authors: Wang Guo-Hong , Yang Long-Fei , Wang Shi-Wei , Liu Yue-Tao 
Published: April 2024

Abstract

Objective:
This study aimed to investigate the orientated effective components of Astragali Radix Huangqi (HQ) in HQ Jianzhong Tang (HQJZ), a classical formula of traditional Chinese medicine (TCM) used for treating chronic atrophic gastritis (CAG), using HQ as a monarch medicine.

Materials and Methods:
The spectra of HQJZ containing different polar parts of HQ were obtained using ultra-high-performance liquid chromatography-Q-Exactive mass spectrometry. Furthermore, the efficacy of HQJZ, which contains different polar parts of HQ, in treating rats with CAG was evaluated using traditional pharmacodynamic and nuclear magnetic resonance-based metabonomics. Grey relation analysis and partial least squares analysis were applied to analyze the spectrum–effect relationship and to screen out the orientated effective components related to HQ in the treatment of CAG.

Results:
Spectrum–effect relationship analysis showed that 24 compounds identified from the fingerprint spectrum were strongly correlated with efficacy. Compounds 8 (calycosin-7-O-glc-6”- O-acetate), 9 (3-hydroxy-9, 10-dimethoxyptercarpan), and 22 (astragaloside II) were ranked among the top three.

Conclusions:
This study showed that integrating metabolomics and spectrum–effect relationship analysis is a powerful tool for obtaining orientated effective components of Chinese medicine in a given TCM formula.
A generalization of immanants based on partition algebra characters
Authors: Campbell John M. 
Published: April 2024

AbstractWe introduce a generalization of immanants of matrices, using partition algebra characters in place of symmetric group characters. We prove that our immanant-like function on square matrices, which we refer to as the recombinant, agrees with the usual definition for immanants for the special case whereby the vacillating tableaux associated with the irreducible characters correspond, according to the Bratteli diagram for partition algebra representations, to the integer partition shapes for symmetric group characters. In contrast to previously studied variants and generalizations of immanants, as in Temperley–Lieb immanants and f-immanants, the sum that we use to define recombinants is indexed by a full set of partition diagrams, as opposed to permutations.
On the Making and Provenancing of Pigments from the Early Dynastic Royal Tombs of Ur, Mesopotamia
Authors: Hauptmann Andreas , Klein Sabine , Zettler Richard , Baumer Ursula , Dietemann Patrick 
Published: April 2024

A total of 50 cosmetic pigments from the Royal Cemetery of the Sumerian city of Ur, Mesopotamia, now in the collections of the Penn Museum, Philadelphia, were investigated for their mineralogical, inorganic, organic and lead isotope composition. The aim of this study was to investigate the making of the pigments and to search for the origin of the material used. Main components of the green pigments were green secondary copper minerals mixed with white hydroxyapatite from bones. Copper acetates and formic acids were detected and the formation of verdigris is discussed. Black pigments mostly consist of black manganese minerals. White pigments were made of oxidized white lead minerals, while in red pigments hematite was detected. Vegetable oil or animal fats were detected in a majority of the pigment samples analyzed, and it appears that the pigments were smoothly smeared into the (shell) containers as a paste, but the modern conservation of the pigments and decomposition of the organics hinders a clear identification of the original organic components. Chemical and lead isotope analyses point to a provenance of the coloring minerals from ore deposits in Oman, on the Iranian Plateau and in southeast Anatolia.
Penguatan Produksi dan Pemasaran UMKM Kue Kering Pastri Kacang
Authors: Herdiana Dyah Susanti  , Moh. Fahrurrozi  , Oktavima Wisdaningrum  , Dian Arief Pradana  , Mahfud Mahfud 
Published: April 2024

Tujuan dari program ini adalah untuk meningkatkan produktivitas dan kualitas produk yang dihasilkan oleh CV. BJP dengan mengurangi produk cacat yang dihasilkan, meningkatkan pengetahuan dan kemampuan dalam mengimplementasikan pengendalian kualitas produksi, perbaikan kemasan, perbaikan strategi pemasaran, membranding produk dan pemasaran produk secara online. Metode yang digunakan dalam program ini adalah 1) pelatihan dan pembinaan, 2) transfer inovasi teknologi tepat guna, 3) pelatihan pengendalian kualitas, manajemen pemasaran dan branding, serta digital marketing. Hasil yang didapatkan dari kegiatan PKM ini adalah fasilitasi mesin penipis adonan pastri, peningkatan kapasitas produksi dari 28 kg per hari menjadi 78 kg per hari, produk cacat yang dihasilkan berkurang hingga 2% dari total produksi.
ANALISIS KETATANEGARAAN BERDASARKAN HISTORIS KETATANEGARAAN REPUBLIK INDONESIA PERIODE ORDE LAMA, ORDE BARU DAN REFORMASI
Authors: Mustamin  
Published: April 2024

Penelitian ini bertujuan untuk mengetahui ketatanegaraan berdasarkan historis ketatanegaraan Republik Indonesia dari periode orde lama, orde baru hingga orde reformasi untuk mengetahui perkembangan kehidupan bernegara secara dinamis terus mengalami dinamika dan perubahan terutama yang berkaitan dengan norma-norma yang berlaku lebih khusus mengatur tentang struktur kekuasaan dan ketatanegaraan pacsa amandemen UUD 1945. Metode penelitian yang digunakan penelitian normatif dengan mengacu pada sumber-sumber seperti peraturan perundang-undangan, buku hukum, dan media cetak. Hasil penelitian menunjukkan proses panjang dari proklamasi 17 Agustus 1945 hingga era reformasi, dengan transisi signifikan antara periode pemerintahan, seperti dari Soekarno ke Soeharto pada 1966 dan mundurnya Soeharto pada 1998-1999. Reformasi puncaknya terjadi pada masa pemerintahan Abdurrahman Wahid dan Megawati Soekarnoputri, dengan gejolak sosial dan perubahan kebijakan seperti memorandum dan maklumat MPR hingga 2001. Pemerintahan SBY 2004-2014 menandai dua periode kekuasaan, diikuti oleh pemerintahan Jokowi-Kalla 2014-2019 dan kemudian Jokowi-Ma'ruf Amin dari 2019 hingga 2024. Masa jabatan terakhir ini menitikberatkan pada peningkatan kualitas sumber daya manusia dan reformasi birokrasi, mencerminkan perubahan konstitusional yang terjadi selama rentang waktu tersebut.
ANALISIS KAPASITAS TAMPUNGAN EMBUNG SERBAGUNA KALEPADANG UNTUK MEMENUHI KEBUTUHAN AIR BAKU PENDUDUK KECAMATAN BONTOHARU
Authors: Tambaru Tambaru 
Published: April 2024

The problem of the availability of raw water is also faced by residents in the Bontoharu District, Selayar Islands Regency. Even though the area has adequate water sources (surface water, river water, underground water, and springs), the problem is how to optimally capture and distribute water from these water sources so that it can be used by residents. Facilities and infrastructure in the raw water supply system such as broncaptering, public service tanks, and pressure relief tanks need to be designed and built so that people can meet their water needs without having to bother taking it directly to water sources which are sometimes very difficult to reach. In preparing the Design Review for the Development of the Kalepadang Multipurpose Reservoir, Kec. Bontoharu. This Methodology of Work Implementation is Preliminary Survey and Investigation, Data Collection, Hydrological Analysis, Reservoir Construction Planning, and Reservoir Construction Stability. Budget Plan. Activities carried out to achieve the goal of community service include an Analysis of the Capacity of a Multipurpose Reservoir as a Reference for the Development of Standard Water Infrastructure to Meet the Water Needs of the Local Population

Masalah ketersediaan air baku ini juga dihadapi oleh penduduk di wilayah Kecamatan Bontoharu Kabupaten Kepulauan Selayar. Meskipun wilayah tersebut memiliki sumber air (air permukaan, air sungai, air bawah tanah dan mata air) yang cukup memadai, namun yang menjadi kendala adalah bagaimana cara menangkap dan menyalurkan air dari sumber air tersebut secara optimal sehingga dapat dimanfaatkan oleh penduduk. Sarana dan prasarana dalam sistem penyediaan air baku seperti broncaptering, bak pelayanan umum dan bak pelepas tekan yang perlu didesain dan dibangun agar masyarakat dapat memenuhi kebutuhan air tanpa harus bersusah payah mengambil langsung ke sumber air yang terkadang sangat sulit dijangkau. Dalam penyusunan Review Desain Pembangunan Embung Serbaguna Kalepadang Kec. Bontoharu. ini Metodologi Pelaksanaan Pekerjaan adalah Survey dan investigasi pendahuluan, Pengumpulan data, Analisis hidrologi, Perencanaan konstruksi embung, Stabilitas konstruksi embung dam Rancangan Anggaran Biaya. Kegiatan yang dilakukan untuk mencapai tujuan pengabdian kepada masyarakat melakukan Analisis Kapasitas Tampungan Embung Serbaguna Sebagai Acuan Pembangunan Prasarana Air Baku Untuk Memenuhi Kebutuhan Air Penduduk Setempat.
PERUBAHAN SIFAT KIMIA DAN POPULASI MIKROBILOGI SELAMA FERMENTASI
Authors: Rujiah Rujiah , Apriyanto Mulono , Alfa Akbar 
Published: April 2024

This study aims to determine changes in chemical properties in the fermentation of dried cocoa beans. Sun-dried cocoa beans obtained from farmers have a non-uniform moisture content. In order to minimize fermentation failure, dry cocoa beans are obtained by drying fresh cocoa beans using a dryer cabinet with previously conditioned temperatures such as drying with sunlight, and each sugar content is determined. Fermentation experiments of dried cocoa beans were carried out fermentation in fermentation containers with a number of beans of 150 grams per container. Before fermenting, dry cocoa beans are rehydrated so that the moisture content is close to fresh beans, then dried cocoa beans are incubated for six days without being turned over during fermentation. Each treatment was repeated three times and observed every 24 hours to 120 hours. The results showed that chemical and physical changes increased according to SNI.

Penelitian ini bertujuan untuk mengetahui perubahan sifat kimia pada fermentasi biji kakao kering jemur. Biji kakao kering jemur yang diperoleh dari petani memiliki kadar air yang tidak seragam. Guna menimalkan kegagalan fermentasi maka biji kakao kering jemur diperoleh melalui pengeringan biji kakao segar menggunakan kabinet dryer dengan sebelumnya dikondisikan pada suhu seperti pengeringan dengan sinar matahari, dan masing ditentukan kadar gula reduksinya. Percobaan fermentasi biji kakao kering dilakukan fermentasi pada wadah fermentasi dengan jumlah biji 150 gram setiap wadah. Sebelum difermentasi terlebih dahulu biji kakao kering jemur di rehidrasi agar didapat kadar air mendekati biji segar, kemudian biji kakao kering jemur diinkubasi selama enam hari dan tanpa dibalik selama fermentasi. Setiap perlakuan diulangi tiga kali dan diamati tiap 24 jam sampai 120 jam. Hasil penelitian menunjukan perubahan kimia dan fisik mengalami peningkatan sesuai SNI.
PERILAKU PASAR KELAPA TINGKAT PETANI
Authors: Mardesci Hermiza , Novitasari Rifni , Yulianti Yulianti , Ninsix Retti , Marlina Marlina , Apriyanto Mulono , Ilyas Ilyas , Widyawati Widyawati 
Published: April 2024

This research aims to analyze the structure, conduct, and performance of the coconut market in the villages of Teluk Dalam, KuIndra Subdistrict. A sampling of farmers using accidental sampling and merchant sampling using the census method. Data analysis descriptively and quantitatively. Descriptively the market structure is seen through the number of market participants and market behavior is seen through the practice of price formation. Quantitatively, market structure analysis uses concentration analysis of market behavior using correlation analysis. The results of this research show Market behavior indicates that factories and traders dominate the market, this is seen from the value of the transmission price <1 are the channels with the lowest margin among the four channels in Teluk Dalam Villages.

Penelitian ini bertujuan untuk menganalisis struktur, perilaku dan kinerja pasar kelapa di desa Teluk Dalam, Kecamatan KuIndra. Pengambilan sampel petani menggunakan accidential sampling dan sampel pedagang menggunakan metode sensus. Analisis data dengan deskriptif dan kuantitatif. Secara deskriptif struktur pasar dilihat melalui jumlah pelaku pasar dan perilaku pasar dilihat melalui praktik pembentukan harga. Secara kuantitatif, analisis struktur pasar menggunakan analisis konsentrasi perilaku pasar dengan menggunakan analisis korelasi. Hasil penelitian ini adalah Perilaku pasar menunjukkan bahwa pabrik dan pedagang mendominasi pasar, hal ini dilihat dari nilai harga transmisi <1 merupakan saluran dengan margin terendah di antara empat saluran di Desa Teluk Dalam.