bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteome analysis identifies novel protein candidates involved in regeneration of the cerebellum of teleost fish
Authors: Zupanc Marianne M. , Wellbrock Ursula M. , Zupanc Günther K. H. 
Published: December 2005

AbstractIn contrast to mammals, adult teleost fish exhibit an enormous potential to regenerate neuronal tissue after injuries to the CNS. By combining a well‐defined cerebellar lesion paradigm with differential proteome analysis at a post‐lesion survival time of 3 days, we screened for protein candidates involved in repair of the fish brain. Out of nearly 900 protein spots detected on 2‐D gels, spot intensity was significantly increased at least twofold in 30 spots and decreased to at least half the intensity of control tissue in 23 spots. The proteins associated with 24 of the spots were identified by PMF and MS/MS fragmentation. The cellular localization and the spatiotemporal patterns of two of these proteins, beta‐actin and beta‐tubulin, were further characterized through immunohistochemistry. Comparison of the observed changes in protein abundance with the previously characterized events underlying regeneration of the cerebellum suggests that the proteins identified are especially involved in cellular proliferation and survival, as well as axonal sprouting.
Expressed proteome analysis of human hepatocellular carcinoma in nude mice (LCI‐D20) with high metastasis potential
Authors: Shen Huali , Cheng Gang , Fan Huizhi , Zhang Jie , Zhang Xiangmin , Lu Haojie , Liu Chunli , Sun Fengxia , Jin Hong , Xu Xuejiao , Xu Guobin , Wang Sheng , Fang Caiyun , Bao Huimin , Wang Yan , Wang Jing , Zhong Hua , Yu Ziniu , Liu Yinkun , Tang Zhaoyou , Yang Pengyuan 
Published: December 2005

AbstractWe report for the first time an expressed proteome for human hepatocellular carcinoma (HCC) in nude mice model. Most cases of human liver cancer are HCC with highly metastatic ability. Therefore, the early prediction or diagnosis and effective treatment are the key points of research. We have previously successfully established a human HCC nude mice model (LCI‐D20) with high metastasis potential. To understand better the tumor biology of HCC it is worth to explore the relativity of all expressed protein profiles in the LCI‐D20 HCC nude mice model. With advanced proteomics technologies, we have carried out a proteomic analysis with following stages: protein sample preparation of cancer tissue, including total cellular extraction and sequential fractionation, 2‐DE and 2‐D LC separation, ESI/MALDI‐MS/MS identification, as well as data‐dependent bioinformatics. The identified proteins were classified bioinformatically respective to their function, biological process and intracellular localization. Some important proteins found in HCC, e.g. metabolism enzymes, proteins regulating cell motility, signaling proteins, and heat shock proteins, are discussed in terms of their metastasis.
Synthesis and characterization of polyimides derived from (3‐amino‐2,4,6‐trimethylphenyl)‐(3′‐aminophenyl)methanone and aromatic dianhydrides
Authors: Li Z. X. , Lin L. Q. , Zhang W. M. , Wu T. , Pu J. L. 
Published: December 2005

AbstractA series of new polyimides were prepared via the polycondensation of (3‐amino‐2,4,6‐trimethylphenyl)‐(3′‐aminophenyl)methanone and aromatic dianhydrides, that is, 3,3′,4,4′‐biphenyltetracarboxylic dianhydride (BPDA), 4,4′‐oxydiphthalic anhydride, 3,3′,4,4′‐benzophenone tetracarboxylic dianhydride, and 2,2′‐bis(3,4‐dicarboxyphenyl) hexafluoropropane dianhydride. The structures of the polyimides were characterized by Fourier transform infrared and NMR measurements. The properties were evaluated by solubility tests, ultraviolet–visible analysis, differential scanning calorimetry, and thermogravimetric analysis. The two different meta‐position‐located amino groups with respect to the carbonyl bridge in the diamine monomer provided it with an unsymmetrical structure. This led to a restriction on the close packing of the resulting polymer chains and reduced interchain interactions, which contributed to the solubility increase. All the polyimides except that derived from BPDA had good solubility in strong aprotic solvents, such as N‐methyl‐2‐pyrrolidinone, N,N′‐dimethylacetamide, N,N‐dimethylformamide, and dimethyl sulfone, and in common organic solvents, such as cyclohexanone and chloroform. In addition, these polyimides exhibited high glass‐transition values and excellent thermal properties, with an initial thermal decomposition temperature above 470 °C and glass‐transition temperatures in the range of 280–320 °C. The polyimide films also exhibited good transparency in the visible‐light region, with transmittance higher than 80% at 450 nm and a cutoff wavelength lower than 370 nm. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 1291–1298, 2006
New combined polymer/chromium approach for investigating the phototransformations involved in hologram formation in dichromated poly(vinyl alcohol)
Authors: Djouani Fatma , Israëli Yaël , Frezet Lawrence , Rivaton Agnès , Lessard Roger A. , Bolte Michèle 
Published: December 2005

AbstractThe photochemical behavior of dichromated poly(vinyl alcohol) films has been analyzed upon exposure at 365 nm in relationship with the performances of holograms recorded in such photosensitive materials. The evolution of both involved species, poly(vinyl alcohol) and chromium, has been quantified by the implementation of an innovative approach. This approach combines the monitoring of the structural modification of the polymeric matrix and the fate of the various chromium species. For the first time, it has been established that chromium(V) not only is an indicator of the hologram quality, as previously assessed, but also appears to be responsible for the crosslinking implied in the hologram formation. Actually, the crosslinking has been proved to proceed through coordination bonds around chromium(V), which acts as a bridge between the polymeric chains. The role played by the ammonium cations in the hologram quality has also been elucidated. The improvement brought by ammonium dichromate with respect to potassium dichromate involves amide groups resulting from poly(vinyl alcohol) phototransformation. These groups provide additional chelating sites for chromium(V), leading to an increase in the matrix crosslinking. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 1317–1325, 2006
Phonon dispersion in polycytidilic acid
Authors: Srivastava Seema , Panday Manish Kumar , Srivastava Shinoo , Gupta Vishwambhar Dayal , Khan I. A. 
Published: December 2005

AbstractA study of the normal modes of vibration and their dispersion in polycytidilic acid based on the Urey–Bradley force field and Raman and Fourier transform infrared spectroscopy is reported. Characteristic features of dispersion curves such as regions of high density of states, repulsion, and character mixing of dispersive modes are discussed. The predictive value of the heat capacity as a function of temperature is reported. © 2005 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 44: 504–516, 2006
Modeling the Porosity Evolution of a Powder under Uniaxial Compression
Authors: Lamy Peggy , Brunet Luc , Thomas Gérard 
Published: December 2005

AbstractThe purpose of this work is to present a new model describing the evolution of powder porosity versus applied pressure during uniaxial compression. This model is based on quasi‐chemical treatments and population balances. It is generally admitted that compression is composed of four steps: a first reorganization of the initial particles, a fragmentation of some initial particles, a second rearrangement of the initial and secondary particle mixture and a plastic deformation stage. So the model is constructed around these four steps. Experimental results on eighteen different powders show a fair agreement with theoretical results and material physical constant values. The use of this model can allow classifying the reorganization, fragmentation and plastic deformation abilities of the products and it will be useful in order to optimize the elaboration process.
Surface Energy and Crystallization Phenomena of Ammonium Dinitramide
Authors: Teipel Ulrich , Heintz Thomas 
Published: December 2005

AbstractAmmonium dinitramide (ADN) was characterized during recrystallization from the melt. The surface tension of molten ADN at 97 °C was measured to be 89 mN/m. The wetting angles between molten ADN and different solid surfaces (polytetrafluoroethylene, glass, steel, and aluminum) were determined. The wettability depends on the surface tension of molten ADN, the free surface energy of the solid surfaces and the interfacial tension between the solid and liquid. Observations of the recrystallization behavior of molten ADN showed that nucleation does not occur, even at super cooling rates of 70 K. Crystallization can be initiated by the application of seed crystals.
High Pressure Raman Spectroscopic Study of the Effects of n‐Ethylamines and Water on the 2‐Nitropropane/Nitric Acid System
Authors: Gobin Cedric , Petitet Jean Pierre 
Published: December 2005

AbstractHigh pressure Raman spectroscopy measurements in a diamond anvil cell (0–10 GPa) on 2‐nitropropane/nitric acid/X (X=triethylamine, diethylamine, and water) ternary systems and 2‐nitropropane/nitric acid/water/Y (Y=triethylamine and diethylamine) quaternary systems are reported. The modifications of the chemical behavior of the 2‐nitropropane/nitric acid model system, induced by the presence of triethylamine, diethylamine, and/or water, were studied at ambient and high pressure. At ambient pressure, the ionization of the nitric acid has been observed with each of the additives. Moreover, in the case of ethylamines, new peaks have been observed and the hypothesis of a 2‐nitropropane/ethylamine complex is advanced. At high pressure, the decomposition of the 2‐nitropropane/nitric acid system, with an oxygen balance near zero, has been observed only in presence of triethylamine. The role of each additive to the 2‐nitropropane/nitric acid system in the modification of the respective reducing and oxidizing character of the components, and in the reactivity of the system, is discussed. Several hypotheses are advanced concerning the sensitizing effect of the additives on the 2‐nitropropane/nitric acid system.
Preparation and Characterization of Reticular Nano‐HMX
Authors: Yongxu Zhang , Dabin Liu , Chunxu Lv 
Published: December 2005

AbstractReticularly structured HMX (octahydro‐1,3,5,7‐tetranitro‐1,3,5,7‐tetrazocine) of nano‐size particles was simply prepared by reprecipitation at room temperature. The sample prepared by reprecipitation was characterized by SEM, TEM, XRD, DSC, and drop weight impact. The results of SEM and TEM indicated that spherical HMX particles of about 50 nm in diameter aggregated into reticularly structured conglomerates. There are two phases (γ‐ and β‐HMX) existing in the reticularly structured HMX as shown in the XRD pattern. It was also proved by DSC that the maximum energy release during decomposition of the reticularly structured HMX is at lower temperature. In addition, the testing result of drop weight impact showed that the reticularly structured HMX is less sensitive to impact.
A Novel Synthetic Route to Hexanitrohexaazaisowurtzitane
Authors: Pang Si‐Ping , Yu Yong‐Zhong , Zhao Xin‐Qi 
Published: December 2005

AbstractA new, non‐hydrogenolytic synthesis of hexanitrohexaazaisowurtzitane (HNIW, 1) has been investigated. The treatment of hexabenzylhexaazaisowurtzitane (HBIW, 2) with potassium permanganate in acetic anhydride resulted in oxidative debenzylation and acetylation to give tetraacetyldibenzylhexaazaisowurtzitane (TADB, 3a) and other intermediates from the oxidation. Subsequent nitrosolysis and nitrolysis of these intermediates with 65% HNO3/NaNO2 and 70% HNO3/AN produced HNIW in fair yield.
Superoxide dismutase in the prostate lobes of aging brown Norway rats
Authors: Pechenino Angela S. , Brown Terry R. 
Published: December 2005

AbstractBACKGROUNDSpontaneous age‐dependent epithelial cell hyperplasia occurs in the lateral and dorsal, but not the ventral, lobes of aging Brown Norway (BN) rats. Diminished antioxidant enzyme activities and increased formation of reactive oxygen species (ROS) promote the pathology of many aging disorders. We investigated the hypothesis that prostatic epithelial cell hyperplasia in the BN rat was related to age‐dependent and/or lobe‐specific changes in superoxide dismutase (SOD).MATERIALS AND METHODSUsing Western blots, immunohistochemistry and enzyme activity assays we determined the levels of protein expression, subcellular localization, and activities, respectively, of the three SOD isoforms, cytoplasmic SOD1, mitochondrial SOD2, and extracellular SOD3 in the ventral, lateral, and dorsal prostate lobes of 4‐month‐old rats with normal prostate morphology, in 24‐month‐old rats with lobe‐specific hyperplasia and in older 30‐month‐old rats.RESULTSWe observed little change in SOD activities as a function of age, although expression of SOD3 increased in the prostatic lobes of older rats. SOD2 levels were higher in the lateral lobe of 4‐ and 24‐month‐old rats, but declined by 30 months of age to levels in the ventral and dorsal lobes. SOD1 was localized by immunohistochemistry to the nuclei of epithelial cells in all lobes, but the number of immunopositive nuclei increased in the lateral and dorsal lobes of 24‐month‐old animals. The concentration of zinc was highest in the prostate lobes of 24‐month‐old animals.CONCLUSIONBased upon our data, superoxide dismutase is not significantly altered in the rat prostate during aging and thus is unlikely to be an important factor in the evolution of epithelial cell hyperplasia. Prostate © 2005 Wiley‐Liss, Inc.
E‐cadherin polymorphisms and haplotypes influence risk for prostate cancer
Authors: Bonilla Carolina , Mason Tshela , Long Layron , Ahaghotu Chiledum , Chen Weidong , Zhao Aiqiu , Coulibaly Aoua , Bennett Frankly , Aiken William , Tullock Trevor , Coard Kathleen , Freeman Vincent , Kittles Rick A. 
Published: December 2005

AbstractBACKGROUNDThe E‐cadherin (CDH1) gene has been implicated in prostate cancer (PCA) risk, however, the exact mechanism is unknown. Several polymorphisms, such as the C/A variant −160 base pairs from the transcription start site, in the CDH1 gene promoter region have been associated with cancer risk, mainly in European descent populations.METHODSWe screened the entire coding region and 3.0 kilobases of the CDH1 promoter for polymorphisms in 48 African Americans using dHPLC. Twenty‐one (21) polymorphisms were observed. Four polymorphisms, including −160C/A, were genotyped in a genetic association study using incident PCA cases (N = 427) and unaffected controls (N = 337) of similar age from three different ethnic groups consisting of African Americans, Jamaicans, and European Americans.RESULTSWe observed a significantly higher frequency of the −160A allele among European American PCA patients (27.5%) compared to the control group (19.7%) (P = 0.04). More importantly, among men of European ancestry under the age of 65 who possess the −160 A allele there was over three times increased risk for prostate cancer (P = 0.05). Also, the AACT haplotype bearing the −160A allele was significantly associated with PCA in European Americans (P = 0.04).CONCLUSIONSOur data indicate that CDH1 likely is a low‐penetrant PCA susceptibility gene, however, population differences in linkage disequilibrium within the CDH1 gene region may influence the effect of susceptibility alleles such as −160A. © 2005 Wiley‐Liss, Inc.
Spatial correlations of most mobile or immobile particles in supercooled Al2O3
Authors: Van Hoang Vo 
Published: December 2005

AbstractSpatial correlations of most mobile and immobile particles in supercooled Al2O3 model at the temperatures of 2100 K have been investigated by using molecular dynamics (MD) method. Simulations were done in the basic cube under periodic boundary conditions containing 3000 ions with Born–Mayer type pair potentials. We evaluate the non‐Gaussian parameter for the self‐part of the van Hove correlation function, atomic displacement distribution (ADD) and cluster‐size distributions of most mobile and immobile particles in the model. We compare the partial radial distribution functions (PRDFs) for the 5% most mobile or immobile Al, O particles with the corresponding mean ones. We have found that mean cluster size grows with decreasing temperature. The composition evolution in subset of most mobile or immobile particles upon cooling and annealing was obtained and presented. The relation between local structure and dynamics in the system has been studied and discussed. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Optical transition properties of the Nd3+ ions in Ca3(BO3)2 crystal
Authors: Lu Xiuai , You Zhenyu , Li Jianfu , Zhu Zhaojie , Jia Guohua , Wu Baichang , Tu Chaoyang 
Published: December 2005

AbstractCa3(BO3)2 single crystals have been grown by the Czochraski technique. The absorption and emission spectra have been measured at room temperature. From the Judd–Ofelt theory analysis, the intensity parameters were determined to be Ω2 = 4.63 × 10–20 cm2, Ω4 = 2.40 × 10–20 cm2, and Ω6 = 10.4 × 10–20 cm2. The calculated radiative probabilities, radiative lifetimes, and the branching ratios have been evaluated for the 4F3/2 excited state using the calculated intensity parameters. The stimulated emission cross‐section was also measured at 1060 nm. The results indicate that this crystal can be considered as a promising material for solid‐state laser application. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Incidence and Impact of Risk Factors in Critically Ill Trauma Patients
Authors: Bochicchio Grant V. , Joshi Manjari , Bochicchio Kelly , Shih Diane , Meyer W. , Scalea Thomas M. 
Published: December 2005

AbstractThere is a paucity of data describing the incidence of pre‐existing diseases or risk factors and their effects in trauma patients. We conducted a prospective study to determine the incidence of such factors in critically ill trauma patients and to evaluate their impact on outcome. The study, performed over a 2‐year period, examined the hospital course of all trauma patients admitted to the ICU. Multiple risk factors were evaluated and analyzed via multivariate regression analysis. Outcome was evaluated by infection rate, hospital length of stay, ventilator days, and mortality matched for age and Injury Severity Score (ISS). A total of 1172 patients (73% blunt injury) were enrolled over the study period. Of these, 873 (74.5%) were male. The mean age was 42.5 years with an ISS of 19.8. Tobacco use (24%) was the most common risk factor identified, followed by hypertension (HTN, 17%), coronary artery disease (9%), chronic obstructive pulmonary disease (COPD)/reactive airway disease (4%), non‐insulin‐dependent diabetes (NIDDM) (4%), insulin‐dependent diabetes (IDDM) (3.2%), cancer (3%), liver disease (2%), and HIV/AIDS (1.4%). Of these risk factors, IDDM was found to be an independent risk factor for infection (0.004) and ventilator days (0.047), increasing age was found to be an independent risk factor for hospital length of stay (0.023) and mortality (<0.001), and HTN was found to be an independent risk factor for increased ventilator days (0.04). In addition, COPD/reactive airway disease was found to be an independent predictor of ventilator days, infection, and ICU days (P < 0.05). Thus, increased age, IDDM, COPD, and HTN are most predictive of outcome in critically ill trauma patients. With our aging population it is becoming increasingly important to identify pre‐existing risk factors on admission in order to minimize their effects on outcome.
Electromyography Monitoring of Patients With Salivary Gland Diseases
Authors: Vaiman Michael , Nahlieli Oded , Segal Samuel , Eviatar Ephraim 
Published: December 2005

OBJECTIVETo provide a description of surface electromyography (sEMG) of spontaneous saliva swallowing (SSS) and monitoring of swallow rate in patients with salivary gland diseases.STUDY DESIGNNumbers of SSS obtained during 2 hours of sEMG monitoring were compared with sialometry data for healthy volunteers (n = 100), patients with Sjögren syndrome (n = 10), and patients after parotid gland (n = 15) and submandibular gland (n = 16) surgery.RESULTSNormative: 1 SSS every 2 minutes and 15 seconds; Sjögren: 1 SSS every 13 minutes (P < 0.001); parotid gland surgery: 1 SSS every 3 minutes and 24 seconds (P = 0.26); submandibular gland surgery: 1 SSS every 5 minutes and 04 seconds (P < 0.05). Sjögren patients and patients after submandibular surgery had hyposalivation correlated with less SSS.CONCLUSIONThe established normal rate of SSS makes this modality applicable for evaluating salivary flow for potentially identifying and ruling out abnormalities. Parotid gland surgery does not significantly affect salivary flow rate. Sialometry combined with sEMG monitoring give a clinician more reliable data to evaluate salivary gland disorders than sialometry alone.EBM RATINGB‐2
Effect of Topical Mitomycin C on the Healing of Surgical and Laser Wounds: A Hint on Clinical Application
Authors: Roh Jong‐Lyel , Koo Bon Seok , Yoon Yeo‐Hoon , Rha Ki Sang , Park Chan IL 
Published: December 2005

OBJECTIVESMitomycin C (MMC) is used in otolaryngological surgery to reduce complications from postoperative scarring. However, the effects of MMC on wound healing at different doses and on different wound types have not been fully described. The aim of this study was to evaluate the effects of topical MMC at 2 different doses on the healing of surgical and laser wounds.STUDY DESIGN AND SETTINGThis was a randomized study using 20 rabbits. Six full‐thickness wounds were made by excision or laser vaporization on the flank skin. The wounds were randomly treated by topical MMC of 0.4 or 1.0 mg/mL or saline for 5 minutes.RESULTSRe‐epithelialization and contraction of the original wounds were significantly delayed by the use of MMC (P < 0.01). The delayed healing effect of MMC was more prominent in the laser wounds than in the excision wounds. MMC inhibited collagen deposition and fibroblast proliferation of wounds on histological analysis. The 2 different concentrations of MMC showed no difference in gross or histological wound healing characteristics.CONCLUSIONOur results showed that MMC delays the healing of wounds as a result of the inhibition of fibrosis, especially for laser wounds.