bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated with Changes in Reproductive Outcomes during the first year of COVID- 19 pandemic in Burkina Faso: A multinomial analysis from a longitudinal study using PMA 2030 data
Authors: Sylvain Y. M. , Joseph Ashaolu 
Published: February 2024

Abstract
Background:The advent of COVID-19 pandemic has dramatically affected women’s life and livelihoods. In the past decade, the promotion of family planning contributed to reduced poverty and averted poor maternal and child outcomes. There is evidence that these gains may be threatened by social restrictions following COVID-19 outbreak.
Methods:We used data from a longitudinal survey collected by the Performance Monitoring Accountability in Burkina Faso. Data were collected over one-year period, from before (November 2019–February 2020) and during (November 2020–February 2021) COVID-19 pandemic. We evaluate changes in reproductive outcomes with respect to changes in health and economic circumstances as well as sociodemographic conditions among 1372 women aged 15-49 at risk of pregnancy and potential contraceptive users. Bivariate and multivariate multinomial logistic regression were performed to examine correlates of reproductive outcomes.
Results:Half (52%) of women did not change their reproductive status. While, 29% had childbearing, 19% started using a contraceptive method. In the multivariate analysis, childbearing was relatively higher among women exposed to family planning promotion, healthcare utilization, but relatively lower among those employed without cash paid and those who experienced household income loss. As of contraception, women exposed to family planning promotion were also associated with a relatively higher contraceptive use while concerns about getting COVID-19 infection had the opposite effect.
Conclusion:After a year period of COVID-19 outbreak, contraceptive adoption increased significantly, but at a slower pace which was not enough to reduce childbearing. The most vulnerable women may remain at greater risk of unintended pregnancies and poor maternal and child outcomes. Therefore, family planning programs should direct their efforts into combatting misinformation and reaching out women in communities in the context of COVID-19 restrictions.
Co-designing a cardiac rehabilitation program with knowledge users for patients with cardiovascular disease from a remote area
Authors: Bernier Jessica , Breton Mylaine , Poitras Marie-Eve 
Published: February 2024

Abstract

Background: Cardiovascular disease is the leading cause of death worldwide. Cardiac rehabilitation (CR) programs are recognized as effective in reducing the burden of cardiovascular disease. However, cardiac rehabilitation programs are offered inequitably across regions, and are available in less than 15% of remote areas worldwide. The main goal of this study was to design a CR program adapted to the contexts of remote areas, in order to improve the service offer for patients.
Methods: We used an iterative user-centered design approach to understand the user context and services offered in cardiac rehabilitation in remote areas. We conducted two co-design processes in two remote regions with knowledge users. Two advisory committees were created in each of these regions, comprising managers (n = 6), healthcare professionals (n = 12) and patients (n = 2). We used the guidelines of an operational model specific to cardiac rehabilitation to conceptualize data collection for the development of the cardiac rehabilitation program. We conducted four cycles of co-design with each of the committees to develop the cardiac rehabilitation program. Qualitative data were analyzed iteratively after each cycle.
Results: The co-design process led to the development of a prototype cardiac rehabilitation program that is similar in both regions, based on a six-phase care and service trajectory contextualized to remote regions. Participants made structural changes to phases 0, 2, 3 and 4 in order to overcome staffing shortages in remote areas. These changes make it possible to decentralize cardiac rehabilitation expertise away from specialized centers, to ensure equity of service across the territory. Therapeutic patient education was integrated into phase 4 to meet patients' needs. Participants suggested that three follow-up offerings could come from nursing services to increase access to the cardiac rehabilitation program (primary care, home care, special chronic disease programs) in patients' home communities.
Conclusion: The co-design process enables us to meet the needs of remote regions in program development. This final program can be the subject of future implementation research.
Blockchain for IoT and Medical Data Management
Authors: El-Hamed Osama M. Abd , El-Samie Fathi E. Abd , Badawy Wael , El-atty Saied M. Abd 
Published: February 2024

Abstract

This paper presents an innovative approach to enhance the security, sharing, and management of medical data in hospitals and clinics through the integration of blockchain technology and Internet of Things (IoT) devices. Traditional databases, while effective, may pose challenges related to data security and accessibility. In response, our proposed system leverages the inherent features of blockchain to establish a tamper-resistant and transparent framework for storing medical records. The core of our solution involves the integration of blockchain in medical data storage, utilizing Raspberry Pi devices equipped with sensors such as DHT11 for data collection. Each patient is uniquely identified and assigned an individualized ID number, acting as a secure password to access and manage their medical records. This not only ensures data privacy but also provides a seamless and secure method for patients to oversee their healthcare information. We propose a partially decentralized blockchain-based system for medical data storage, constructed from scratch using TypeScript. Additionally, we provide a proof of concept that demonstrates the practical implementation of blockchain in the realm of Electronic Health Records (EHR), utilizing a temperature sensor (DHT11) connected to a Raspberry Pi specifically designed for IoT medical records systems. This multifaceted approach contributes to advancing the field by offering a secure, transparent, and patient-centric system for healthcare data management.
The Course of Moderate-to-Severe Headaches in Patients Undergoing Endovascular Treatment for Unruptured Intracranial Aneurysms: A retrospective cross-sectional Study
Authors: Choi Jin Young , Kim Young Bae , Chung Joonho , Park Keun Young , Han Hyun Jin , Kim Junhyung , Park Sang Kyu 
Published: February 2024

Abstract
Background
This retrospective cross-sectional study aimed to investigate the course of newly onset moderate-to-severe headaches in patients who underwent endovascular treatment (EVT) for unruptured intracranial aneurysms (UIAs).
Methods
Between September 2009 and May 2022, 412 patients were included, and all met the following criteria: (1) presence of UIAs on computed tomography angiography or magnetic resonance angiography; (2) newly onset moderate-to-severe headache (Numeric Rating Scale, NRS ≥ 4) around the time of UIAs diagnosis; and (3) EVT of UIAs. We evaluated initial and follow-up NRS scores to determine the significance of NRS changes and identified predisposing factors for headache improvement at the 12-month follow-up.
Results
Compared to the NRS score before EVT, the average NRS scores significantly decreased at discharge (P < 0.05). Subsequently, the follow-up NRS scores at 1-month, 6-month, and 12-month were significantly decreased (P < 0.01). Follow-up NRS scores decreased continuously until the 12-month follow-up. In multiple logistic regression analysis, a history of stroke (odds ratio [OR] = 0.539, 95% confidence interval [CI] 0.196 to 0.806; P = 0.039) and procedure-related complications (OR = 0.567, 95% CI 0.218 to 0.728; P = 0.045) were identified as independent predisposing factors of headache improvement.
Conclusions
After EVT of UIAs, patients with newly onset moderate-to-severe headaches experienced significant headache improvement at discharge, with NRS scores continuously decreasing over the 12 months of follow-up. Headache improvement might be expected in patients who do not have a history of stroke and in those who have not experienced procedure-related complications.
Applicability of the pipe-model theory to seedlings of hinoki cypress (Chamaecyparis obtusa)
Authors: Ogawa Kazuharu 
Published: February 2024

Abstract
According to the pipe-model theory, the relationship between the cumulative mass of leaves [F(z)] and the density of non-photosynthetic organs [C(z)] at depth z from the crown surface is linear for adult trees. However, the present study of seedlings of Chamaecyparis obtusa demonstrates that the F(z)–C(z) relationship can be approximated as a non-rectangular hyperbola with convexity (θ) between 0 and 1. For θ=1, the F(z)–C(z) relationship is linear, in accordance with adult trees. Therefore, the basic concept of pipe-model theory regarding the F(z)–C(z) relationship can be generalized as a non-rectangular hyperbola for both growth stages (i.e., seedlings and adult trees). The difference between linearity (θ = 1) and curvilinearity \(\left(\theta \ne 1\right)\)in the F(z)–C(z) relationship corresponds to the difference in proportional area of sapwood in the studied seedlings. Thus, the proportional sapwood area is larger for seedlings with a linear F(z)–C(z) relationship than for seedlings with a curvilinear F(z)–C(z) relationship. The relationship between convexity and the square of stem diameter at the crown base showed scatter in terms of both season and seedling size, indicating that the size dependence of the degree of curvature in the F(z)–C(z) relationship for seedlings remains unclear. The allometric relationship between leaf mass and the square of stem diameter at crown base tended to separate seedlings from adult trees. Seedlings have more leaves per stem cross-sectional area at crown base than adult trees, as seedling stems are mostly composed of sapwood, which functions as an assemblage of living pipes connected to the leaves. Greater scattering of data for seedlings than adult trees in the allometry between leaf mass and the square of stem diameter at crown base could be explained by the non-rectangular hyperbola of the F(z)–C(z) relationship.
Differentially expressed genes and ceRNA network of early subperiosteal osteogenesis in rabbit skull defect models
Authors: Wang Wenxue , Zhao Baodong , Xu Hao , Zhen Li , Li Xin 
Published: February 2024

Abstract
Objective
To explore potential critical genes and identify ceRNA network participating in early stage of subperiosteal osteogenesis.
Materials and Methods
Rabbit skull defect models were constructed. The periosteum of defects and control site were obtained 3 weeks postsurgery, and a bioinformatics method was used to analyze differentially expressed (DE) genes and construct a ceRNA regulatory network.
Results
In total, 332 lncRNAs, 22 circRNAs, 37 miRNAs and 1141 mRNAs were differentially expressed. The functional enrichment suggested the immune response, cell-cell interaction, cell proliferation and differentiation, and angiogenesis were associated with wound healing and osteogenesis at an earlier stage. CeRNA networks with 39 lncRNA/ 33 miRNAs/ 51mRNAs and 8 circRNAs/ 9 miRNAs/ 46 mRNAs. were constructed respetively.
Conclusion
Expression gene profiles were significantly altered in periosteum during early healing stages of bone regeneration. This study revealed potentially important genes, pathways and ceRNA regulatory networks participating in intramembranous osteogenesis.
Anatomical Description of the Brachial Plexus Nerves in Sphiggurus Villosus (Cuvier, 1823) (Rodentia: Erethizontidae): A Comparative Analisys
Authors: Estruc¹ Thais Mattos , Nascimento¹ Renata Medeiros , Carvalho² Natan Cruz , Santos-Sousa³ Carlos Augusto , Souza-Júnior² Paulo , Abidu-Figueiredo¹ Marcelo 
Published: February 2024

Abstract

The aim of this study was to describe the origin and branches of the brachial plexus nerves in S. villosus, as well as the innervated musculature, contributing information to the field of comparative animal anatomy and providing insights for applied studies. Fifteen adult cadavers (eight males and seven females), previously identified, sexed, and fixed with a 10% aqueous formaldehyde solution, were used. They underwent digital radiographic examinations of the cervical region to characterize the number of cervical vertebrae. The nerves were dissected up to the innervation of the intrinsic and extrinsic musculature of the thoracic limb. With the assistance of a costotome, the vertebrae were removed until the visualization of the spinal cord and the roots giving rise to the nerve branches. The specimens presented seven cervical vertebrae, and the brachial plexus was characterized as post-fixed, formed by connections between the last four cervical spinal nerves (C5, C6, C7, and C8) and the first two thoracic nerves (T1 and T2). The cranial, middle, and caudal trunks originated the suprascapularis, subscapularis, axillary, musculocutaneous, radial, median, and ulnar nerves for intrinsic musculature, and the cranial pectoral, caudal pectoral, lateral thoracic, long thoracic, and thoracodorsal nerves for extrinsic musculature. The ventral branches that contributed the most to the plexus formation in the right antimer were C5 and C8, while in the left antimer, it was C7. The resulting nerves and the innervation for extrinsic and intrinsic musculature were similar to those observed in other rodents and representatives of the Mammalia class in general.
Analysis of underlying disease and infection source with sepsis patients: A 10-year prospective study
Authors: Feng Qiangsheng , Xiaoqin Ha , yuejuan Song 
Published: February 2024

Abstract
Sepsis with high mortality in critically ill patients, although there are many methods for early identification of sepsis such as qSOFA and NEWS, which patients with underlying diseases or infection sites were more prone to sepsis with very little research, our objective to explore another way to the successful preventing sepsis. We collected 2789 sepsis patients who were diagnosed by positive blood culture from 2013 to 2023 in our hospital. The Sepsis incidence rate was 485.07/100 000 in hospitalization, males/females 1.85, there were 3088 pathogenic were isolated belonging to 165 species, E. coli was the most frequent agent 31.70% overall, followed by Klebsiella pneumoniae and S. aureus accounting for 14.33% and 11.26% respectively. We found cancers were the frequent underlying disease with sepsis accounting for 15.63% overall, followed by hematologic malignancy, uremia, gallstones, and cholecystitis, type 2 diabetes accounting for 14.49%,6.10%,5.81%, and 4.48% respectively. We found urinary tract infections (UTIs) were the first infection source accounting for 17.0% overall, followed by suppurative cholecystitis and cholangitis, pulmonary infection, and catheter-associated bloodstream infections (CABSIs) accounted for 12.7%,11.9%, and 11.0% respectively. The sepsis mortality was 32.27%, ICU, hematologic malignanc, cancers, candidemia, mixed infection, pulmonary infection, and abdominal sepsis being the main mortality risk factors. Those studies reveal sepsis was common with cancers and hematologic malignancy patients, infection sources were mainly UTIs, suppurative cholecystitis and cholangitis, pulmonary infection, and CABSIs, the mortality risk factors for BSIs were ICU, hematologic malignancy, cancers, and candidemia.
Making Sense of Change after Intensive Trauma Treatment; a Mixed- Method Study into Adolescents Experience of Efficacy
Authors: Ee Elisa van , de Beijer Dani , Florisson Desirée , Geuskens Fenna 
Published: February 2024

Abstract
While evidence-based interventions are effective for children with post-traumatic stress disorder (PTSD), some adolescents may not respond sufficient. Intensive trauma treatment (ITT) has shown promise for adults, but research on its efficacy for adolescents is limited. This study adopts a mixed-method approach, combining clinical data and narratives, to explore the efficacy and subjective experience of change in 22 adolescents participating in ITT. Quantitative analysis revealed a significant reduction in PTSD symptoms post-ITT, aligning with prior research. Qualitative analysis highlighted themes such as negative thoughts impacting treatment success, the importance of social support, and identity-related struggles. The study contributes to understanding ITT efficacy and emphasizes the need for developmental sensitivity, systemic interventions, and continued research to enhance PTSD treatment for adolescents.
Effect of Rab8a on proliferation and migration of esophageal squamous cell carcinoma cells and its molecular mechanism
Authors: Liu Rong , Kang Zhanting , Gan Ting , Wang Yangruonan , Huangfu Zhiyuan , Cui Jing , Wang Yongxia 
Published: February 2024

Abstract
Purpose To explore the expression and function of Rab8a in esophageal squamous cell carcinoma (ESCC).
Methods The study first used TIMER, GEPIA and UALCAN to analyze the expression of Rab8a in a variety of clinically common malignancies including ESCC, followed by real-time PCR (quantitative real-time PCR, qPCR), Western blot, immunohistochemical (IHC) tests, and a series of in vitro biological experiments.
Results Rab8a is highly expressed in the esophageal cancer cells and tissues, and its expression is significantly correlated with the size and depth of invasion of the esophageal squamous carcinoma. overexpression of Rab8a can promote the proliferation and migration of ESCC while knockdown its expression can inhibit the proliferation and migration of ESCC, indicating a positive correlation of Rab8a with NDUFA1 and CYC 1 expression through GEO database analysis. Therefore, Rab8a may promote ESCC progression by activating mitochondrial respiration.
Conclusions
This study demonstrated that Rab8a is upregulated in ESCC and may promote its proliferation and migration by activating mitochondrial respiration. This study provides a rationale for clinical diagnosis and screening of new therapeutic targets for ESCC.
Efficacy and Safety of Conservative Treatment in Patients with Neurologically Intact Thoracolumbar Burst Fractures: A Meta-Analysis
Authors: Grin Andrey , Karanadze Vasiliy , Kordonskiy Anton , Talypov Aleksandr , Lvov Ivan 
Published: February 2024

Abstract
Objective: To conduct a systematic review and meta-analysis of studies focused on conservative treatment for thoracolumbar burst fractures (TLBF), and to determine efficacy and safety of this method in these patients.
Materials and Methods: The study was performed following PRISMA guidelines. Inclusion criteria were: 1) full-text articles in English and Russian; 2) A3 or A4 type fractures according AOSpine classification; 3) absence of neurological deficit; 4) patients aged over 18 years; 5) detailed description of treatment outcomes or complications; 6) a follow-up of at least one year.
Results: A total of 29 studies, including 1107 patients, were analyzed. Initial assessments showed a pooled mean for Cobb angle of 13.60 (95%CI, 10.8 – 16.5), vertebral body compression percentage of 39.9% (95%CI, 27.7 – 52.0), and spinal canal stenosis of 41.7% (95%CI, 29.2 – 54.2). Follow-up assessments indicated a significant increase in Cobb angle by 3.70 and vertebral body compression by 3.7%. The pooled prevalence for neurological deficit development and progression of TLBF instability were 5.8% (95%CI, 4.1 - 8.1) and 6.5% (95%CI, 4.5 - 9.3) respectively. Work status according to Denis scale was as follows: 1) W1 and W2, 74.7% (95%CI, 63.9 - 83.1); 2) W3, 14.1% (95%CI, 10.2 - 19.3); 3) W4 and W5, 14.8% (95%CI, 8.8 - 23.9).
Conclusion: Conservative therapy is an effective and safe option for patients with TLBF without neurological deficits and with initial kyphotic deformity up to 16°, vertebral body compression percentage up to 52%, and spinal canal stenosis up to 54.2%. The incidence of radiculopathy or myelopathy under conservative treatment is 5.8%. Orthopedic intervention may be required in 6.5% of patients. Over 90% of patients return to full-time work, either in their previous roles or under modified conditions. Future comparative studies between conservative and surgical treatments are needed to establish clear guidelines for managing patients with neurologically intact TLBF.
Synthesis, Characterization, and Evaluation of Antibacterial and Anticorrosion Properties of 4-Azo-3,5-sustituted-1,2,4-Triazole Polymers
Authors: Hamzah Bahaa Fadhil , Mhaibes Raed Muslim 
Published: February 2024

Abstract
In this study, a series of 4-azo derivatives of 1,2,4-triazole were synthesized through the reaction of melt thiocarbohydrazide with various substituted benzoic acids. Subsequently, these derivatives were coupled with different aromatic amines to obtain 4-azo derivatives of 1,2,4-triazole. The synthesized derivatives were then converted into 4-azo-3,5-substituted-1,2,4-triazole polymers using dry acetonitrile, pyridine, and poly acryloyl chloride. The physical properties, FT-IR spectra, and 1H-NMR spectra (for selected compounds) were utilized to confirm the structures of the synthesized compounds and polymers. Furthermore, the antibacterial and anticorrosion activities of the compounds and polymers were investigated.
COVID-19 Vaccine Uptake in Individuals with Functional Difficulty, Disability, and Comorbid Conditions: Insights from a National Survey in Bangladesh
Authors: Khanam Shimlin Jahan , Rana Md Shohel , Islam M Mofizul , Khan Md Nuruzzaman 
Published: February 2024

Abstract

Background: COVID-19 vaccine coverage among individuals with disabilities is crucial for safeguarding their health and well-being. However, the extent of vaccine coverage among this group remains largely unknown in low- and middle-income countries. This study aims to explore the COVID-19 vaccine coverage among persons with functional difficulty, disability and/or morbidity in Bangladesh.
Methods: Data from 9,370 respondents extracted from the 2021 National Household Survey on Persons with Disability were analysed. The outcome variable was the receipt of at least one dose of the COVID-19 vaccine (yes, no). Key explanatory variables included the presence of disability (yes, no), morbidity (yes, no), and both morbidity and disability (yes, no) among persons with functional difficulty. The relationship between the outcome and explanatory variables was determined using multilevel logistic regressions adjusted for covariates.
Results: The overall acceptance rate for at least one dose of the COVID-19 vaccine among persons with functional difficulty was 57.37%, among persons with functional difficulty and disability was 48.63% and among persons with functional difficulty and single (57.85%) or multi-morbidity (60.37%). Compared to the respondents with functional difficulty only, the adjusted odds ratio (aOR) of acceptance of at least one dose of the COVID-19 vaccine for individuals with both functional difficulty and disability was 0.73 (95% CI, 0.65-0.82) and 0.77 (95% CI, 0.70-0.87) for individuals with functional difficulty, disability and one or more comorbid conditions. The aOR for individuals with functional difficulty and one or more morbid conditions was significantly higher than that for persons with functional difficulty only.
Conclusion: In Bangladesh, COVID-19 vaccine coverage was relatively low among individuals with disabilities. The existing COVID-19 vaccine rollout programs and similar future programs should prioritise individuals with disabilities and include targeted strategies to reach them.