bluuebunny/crossref_metadata_2025_split huggingface dataset:
The eukaryotic-like characteristics of small GTPase, roadblock and TRAPPC3 proteins from Asgard archaea
Authors: Tran Linh T. , Akıl Caner , Senju Yosuke , Robinson Robert C. 
Published: March 2024

AbstractMembrane-enclosed organelles are defining features of eukaryotes in distinguishing these organisms from prokaryotes. Specification of distinct membranes is critical to assemble and maintain discrete compartments. Small GTPases and their regulators are the signaling molecules that drive membrane-modifying machineries to the desired location. These signaling molecules include Rab and Rag GTPases, roadblock and longin domain proteins, and TRAPPC3-like proteins. Here, we take a structural approach to assess the relatedness of these eukaryotic-like proteins in Asgard archaea, the closest known prokaryotic relatives to eukaryotes. We find that the Asgard archaea GTPase core domains closely resemble eukaryotic Rabs and Rags. Asgard archaea roadblock, longin and TRAPPC3 domain-containing proteins form dimers similar to those found in the eukaryotic TRAPP and Ragulator complexes. We conclude that the emergence of these protein architectures predated eukaryogenesis, however further adaptations occurred in proto-eukaryotes to allow these proteins to regulate distinct internal membranes.
TREM2 protects from atherosclerosis by limiting necrotic core formation
Authors: Piollet Marie , Porsch Florentina , Rizzo Giuseppe , Kapser Frederieke , Schulz Dirk J. J. , Kiss Máté G. , Schlepckow Kai , Morenas-Rodriguez Estrella , Sen Mustafa Orkun , Gropper Julius , Bandi Sourish Reddy , Schäfer Sarah , Krammer Tobias , Leipold Alexander M. , Hoke Matthias , Ozsvár-Kozma Mária , Beneš Hannah , Schillinger Martin , Minar Erich , Roesch Melanie , Göderle Laura , Hladik Anastasiya , Knapp Sylvia , Colonna Marco , Martini Rudolf , Saliba Antoine-Emmanuel , Haass Christian , Zernecke Alma , Binder Christoph J. , Cochain Clément 
Published: March 2024

AbstractAtherosclerosis is a chronic disease of the vascular wall driven by lipid accumulation and inflammation in the intimal layer of arteries, and its main complications—myocardial infarction and stroke—are the leading cause of mortality worldwide1,2. Recent studies have identified triggering receptor expressed on myeloid cells 2 (TREM2), a lipid-sensing receptor regulating myeloid cell functions3, to be highly expressed in macrophage foam cells in experimental and human atherosclerosis4. However, the role of TREM2 in atherosclerosis is not fully known. Here we show that hematopoietic or global TREM2 deficiency increased, whereas TREM2 agonism decreased, necrotic core formation in early atherosclerosis. We demonstrate that TREM2 is essential for the efferocytosis capacities of macrophages and to the survival of lipid-laden macrophages, indicating a crucial role of TREM2 in maintaining the balance between foam cell death and clearance of dead cells in atherosclerotic lesions, thereby controlling plaque necrosis.
Key components of sustainable climate-smart ocean planning
Authors: Frazão Santos Catarina , Agardy Tundi , Crowder Larry B. , Day Jon C. , Pinsky Malin L. , Himes-Cornell Amber , Reimer Julie M. , García-Morales Sara , Bennett Nathan J. , Lombard Amanda T. , Calado Helena , Scherer Marinez , Flannery Wesley , Wedding Lisa M. , Gissi Elena 
Published: March 2024

AbstractPlanning of marine areas has spread widely over the past two decades to support sustainable ocean management and governance. However, to succeed in a changing ocean, marine spatial planning (MSP) must be ‘climate-smart’— integrating climate-related knowledge, being flexible to changing conditions, and supporting climate actions. While the need for climate-smart MSP has been globally recognized, at a practical level, marine managers and planners require further guidance on how to put it into action. Here, we suggest ten key components that, if well-integrated, would promote the development and implementation of sustainable, equitable, climate-smart MSP initiatives around the globe.
Exploring the carbonic anhydrase-mimetic [(PMDTA)2ZnII2(OH−)2]2+ for nitric oxide monooxygenation
Authors: Das Sandip , Kumar Pankaj 
Published: March 2024

The reaction of ZnII-hydroxide (1) with NO showed the generation ZnII–nitrito complex (3) with H2 gas evolution via a proposed ZnII-nitrous acid intermediate.
A person re‐identification method for sports event scenes incorporating textual information mining
Authors: Wang Runmin , Zhu Yanbin , Wan Zukun , Chen Hua , Zhu Zhenlin , Zhou Weixin , Han Chang , Ding Yajun 
Published: March 2024

AbstractPerson re‐identification represents a pivotal sub‐problem in image retrieval, boasting broad application prospects in fields such as intelligent security and video surveillance. However, most existing person re‐identification methods predominantly focus solely on visual features pertaining to the person targets, thereby disregarding some supporting information closely related to the scene context. In the context of athlete re‐identification during sports event scenes, the athlete bib number is fully considered, an important clue that can provide different athletes' identities, and the traditional visual features of the person and high‐level semantic information of the bib number text are fused. A multi‐source information mutual gain mechanism is designed to improve the accuracy of the person re‐identification task. In the existing only publicly available marathon bib number dataset RBNR, the recognition accuracy of this method is significantly superior to that of the existing person re‐identification method. In addition, this paper constructs and publishes an athlete re‐identification dataset (HNNU‐ReID8000) for mainstream sports events, and the mean average precision (mAP) value of this method reaches 96.1% on this dataset, significantly ahead of existing state‐of‐the‐art person re‐identification methods. The code and the HNNU‐ReID8000 dataset will be released at https://github.com/yanbin‐zhu/zyb_person‐reid.
A multidimensional fusion image stereo matching algorithm
Authors: Quan Zhenhua , Luo Liang , Wu Bin 
Published: March 2024

AbstractIn response to the low matching accuracy of stereo matching algorithms in image regions with specular reflection, this paper proposes a multidimensional fusion stereo matching algorithm named MFANet. The algorithm embeds a multispectral attention module into the residual feature extraction network, utilizing two‐dimensional discrete cosine transforms to extract frequency features. In the pyramid pooling module, a coordinated attention mechanism is introduced to capture relevant positional information. In the cost aggregation part, the MFANet algorithm incorporates a three‐dimensional attention mechanism, focusing on the more important semantic information in high‐level features. By combining detailed information from low‐level features, semantic information from high‐level features, and contextual information, the algorithm generates features that are more conducive to disparity prediction. The MFANet algorithm is evaluated on three standard datasets (SceneFlow, KITTI2015, and KITTI2012). Experimental results demonstrate its robustness against specular reflection interference, accurate prediction of disparities in specular reflection pathological regions, and promising application prospects.
Beatmungsspezifische Hilfsmittelversorgung – bedarfsgerecht und
sicher?
Authors: Lehmann Yvonne , Stark Susanne 
Published: March 2024

Zusammenfassung
Einleitung Für häuslich beatmete Patient*innen ist die Versorgung mit
Hilfsmitteln essenziell. Dabei ist weitgehend unklar, wie bedarfsgerecht und
sicher diese Versorgung ist.
Methodik Innerhalb eines Versorgungsforschungsprojekts wurden 20
Experteninterviews mit einer heterogenen Gruppe von Akteur*innen mit Bezug zur
beatmungsspezifischen Hilfsmittelversorgung geführt und
qualitativ-inhaltsanalytisch ausgewertet.
Ergebnisse Deutlich werden Herausforderungen und Probleme hinsichtlich
struktureller, prozessualer und personaler Aspekte auf allen Ebenen der
Versorgung. Besondere Defizite bestehen in der Aufgabenwahrnehmung, Koordination
und Kooperation der beteiligten Akteur*innen und Instanzen. Sie gehen mit
vermeidbaren Sicherheitsrisiken einher und stehen einer bedarfsgerechten
Hilfsmittelversorgung im Wege.
Schlussfolgerung Es bestehen Entwicklungsbedarfe in der HM-Versorgung
häuslich beatmeter Patient*innen, vor allem in Richtung einer evidenzbasierten
Weiterentwicklung, einer flächendeckenden, sektoren- und
professionsübergreifenden Ausgestaltung sowie einer systematischen
Evaluation.
Implications of Online Self-Diagnosis in Psychiatry
Authors: Monteith Scott , Glenn Tasha , Geddes John R. , Whybrow Peter C. , Achtyes Eric D. , Bauer Michael 
Published: March 2024

AbstractOnline self-diagnosis of psychiatric disorders by the general public is
increasing. The reasons for the increase include the expansion of Internet
technologies and the use of social media, the rapid growth of direct-to-consumer
e-commerce in healthcare, and the increased emphasis on patient involvement in
decision making. The publicity given to artificial intelligence (AI) has also
contributed to the increased use of online screening tools by the general
public. This paper aims to review factors contributing to the expansion of
online self-diagnosis by the general public, and discuss both the risks and
benefits of online self-diagnosis of psychiatric disorders. A narrative review
was performed with examples obtained from the scientific literature and
commercial articles written for the general public. Online self-diagnosis of
psychiatric disorders is growing rapidly. Some people with a positive result on
a screening tool will seek professional help. However, there are many potential
risks for patients who self-diagnose, including an incorrect or dangerous
diagnosis, increased patient anxiety about the diagnosis, obtaining unfiltered
advice on social media, using the self-diagnosis to self-treat, including online
purchase of medications without a prescription, and technical issues including
the loss of privacy. Physicians need to be aware of the increase in
self-diagnosis by the general public and the potential risks, both medical and
technical. Psychiatrists must recognize that the general public is often unaware
of the challenging medical and technical issues involved in the diagnosis of a
mental disorder, and be ready to treat patients who have already obtained an
online self-diagnosis.
Low-dose pulsed vs standard pulsed fluoroscopy during ERCP to reduce radiation without change in image quality: Prospective randomized study
Authors: Ali Osman , Kesar Varun , Alizadeh Madeline , Kalachi Kourosh , Twery Benjamin , Wellnitz Nicholas , Kim Raymond Eunho , Goldberg Eric , Uradomo Lance T , Darwin Peter E 
Published: March 2024

Abstract
Background and study aims Endoscopic retrograde cholangiopancreatography (ERCP) poses the risk of radiation exposure (RE) to patients and staff and increases the risk of adverse biological effects such as cataracts, sterility, and cancer. Newer fluoroscopy equipment (C-Arm) provides options to limit radiation in the form of lower radiation dose and frame rate or time-limited “pulsed” settings. However, the impact of lower settings on image quality has not been assessed, and no standard protocol exists for fluoroscopy settings used during ERCP.
Patients and methods This was a single-center, double-blind, prospective randomized study of consecutive adult patients undergoing standard-of-care ERCP at a tertiary academic medical center. Patients were randomized into two groups: 1) standard-dose pulsed and 2) low-dose pulsed. Pulsed mode (8 fps) was defined as x-ray exposure either in the manufacturer standard-dose or low-dose settings limited to 3 seconds each time the foot-operated switch was depressed.
Results Seventy-eight patients undergoing ERCP were enrolled and randomized. No difference in age, gender, or body mass index was found between the two groups. No significant difference in image quality was found between standard-dose and low-dose fluoroscopy P = 0.925). The low-dose group was exposed to significantly less radiation when compared with standard-dose P < 0.05). Fluoroscopy time (minutes) was similar in both groups (2.0 vs 1.9), further suggesting that group assignment had no impact on image quality or procedure time.
Conclusions Low-dose pulsed fluoroscopy is a reliable method that substantially reduces radiation without compromising image quality or affecting procedure or fluoroscopy times. This underscores the need for standardization in ERCP fluoroscopy settings to limit radiation exposure.
Efficacy and safety of the water pressure method for endoscopic submucosal dissection in superficial pharyngeal cancer
Authors: Matsuura Noriko , Kato Motohiko , Iwata Kentaro , Miyazaki Kurato , Masunaga Teppei , Kubosawa Yoko , Mizutani Mari , Hayashi Yukie , Sasaki Motoki , Sujino Tomohisa , Takabayashi Kaoru , Akimoto Teppei , Takatori Yusaku , Nakayama Atsushi , Sekimizu Mariko , Ozawa Hiroyuki , Yahagi Naohisa 
Published: March 2024

Abstract
Background and study aims Superficial pharyngeal cancers can be cured with transoral surgery (TOS), which preserves organ function and quality of life. Pharyngeal endoscopic submucosal dissection (ESD) is challenging to perform because of limited maneuverability and complex anatomical features. The water pressure method (WPM) is useful for natural traction techniques during ESD and is potentially useful for pharyngeal ESD. This study aimed to investigate the short-term outcomes of WPM-ESD for pharyngeal lesions.
Patients and methods Therapeutic outcomes of patients who underwent WPM-ESD for pharyngeal lesions at Keio University between May 2019 and February 2022 were retrospectively analyzed.
Results Twenty-one pharyngeal lesions treated with WPM-ESD were analyzed. Three lesions were located in the oropharynx and 18 in the hypopharynx. All ESD procedures were performed under general anesthesia. The endoscopic en bloc resection rate was 100%. The median procedure time was 15 minutes (range 4–45 minutes). All patients were successfully extubated on the day of ESD. No serious adverse events (AEs) related to WPM-ESDs were observed. None of the patients required nasogastric intubation, percutaneous endoscopic gastrostomy, or tracheotomy. The median fasting time and hospital stay were 2 days (range 2–5 days) and 6 days (range 6–10 days), respectively. All the histological results indicated squamous cell carcinoma. The complete histologic resection rate was 76.2%.
Conclusions WPM-ESD achieved a high en bloc resection rate and short procedure time without serious AEs. Thus, it may be a useful treatment for pharyngeal lesions.
Potential for expanded application of endoscopic hand suturing: A pilot study of 15 cases
Authors: Higuchi Kazutoshi , Goto Osamu , Koizumi Eriko , Nakagome Shun , Habu Tsugumi , Ishikawa Yumiko , Kirita Kumiko , Noda Hiroto , Onda Takeshi , Omori Jun , Akimoto Naohiko , Iwakiri Katsuhiko 
Published: March 2024

AbstractEndoscopic hand suturing (EHS) was first developed to firmly close a mucosal defect following endoscopic submucosal dissection and has the potential for expanded applications. This study aimed to investigate the feasibility and safety of EHS in various clinical settings. In this single-center pilot study, 15 patients who had diseases with potential indications for EHS were prospectively recruited. Technical success, clinical success after the procedure, and severe EHS-related adverse events (AEs) were evaluated. EHS was applied for defect closure after gastric subepithelial lesion removal under laparoscopic observation (n = 9), defect closure after rectal endoscopic full-thickness resection (EFTR) (n = 2), defect closure after thoracoscopy-assisted esophageal EFTR (n = 1), mucosal closure for gastric ulcer bleeding (n = 1), mucosal closure after peroral endoscopic myotomy (POEM) (n = 1), and postoperative anastomotic leak (n = 1). EHS was completed without severe AEs and the clinical courses were also favorable in 13 patients (87%). The median suturing time was 61 minutes. In patients with POEM and anastomotic leak, EHS was discontinued because of the narrow lumen. In conclusion, EHS appears feasible and safe in situations.
Impact of a new dedicated sheath device for tissue sampling of biliary stricture on pathological diagnostic yield: Retrospective study
Authors: Niiya Fumitaka , Ishiwatari Hirotoshi , Sasaki Keiko , Ishikawa Kazuma , Sato Junya , Kishida Yoshihiro , Imai Kenichiro , Hotta Kinichi , Ono Hiroyuki 
Published: March 2024

Abstract
Background and study aims Endoscopic transpapillary biliary forceps biopsy (TBFB) is a common method for obtaining specimens from biliary lesions. Its diagnostic yield is unsatisfactory; to overcome this disadvantage, a dedicated sheath has been developed. This study aimed to evaluate the outcomes of conventional TBFB and TBFB with a novel sheath device.
Patients and methods Consecutive patients who underwent TBFB between January 2020 and December 2021 were retrospectively evaluated. The rate of obtaining adequate samples, failed attempts at forceps insertion into the bile duct, and sensitivity were compared between the two groups.
Results Ninety-two patients who underwent 115 endoscopic retrograde cholangiopancreatographies (76 in the conventional group vs. 39 in the dedicated sheath group) were included. The rates of obtaining adequate samples, failed attempts of the forceps into the bile duct, and sensitivity were 72.4% vs. 89.7% (P = 0.03), 28.3% vs. 0% (P < 0.01), and 66.7% vs. 88.9% (P = 0.02), respectively.
Conclusions TBFB with the novel sheath device contributed to improved sensitivity for diagnosis of biliary stricture without insertion of forceps outside the bile duct.
Intermediary Perception of Narcissistic and Humble CEO Traits
Authors: Brunzel Johannes 
Published: March 2024

AbstractThe media plays a key role in bridging information asymmetries between parties such as CEOs and third-party observers. However, current research suggest that the media is not just a carrier of information but can actively shape the impression of the audience. An open question remains, hence, whether media reporting is affected by certain CEO traits such as narcissism or humility, two key constructs in the literature. For instance, narcissistic CEOs’ belief in their own superiority may spillover to the media, thereby distorting the function as information carrier and favoring directly or indirectly certain CEO traits. Therefore, by drawing on the differential effects that narcissism and humility can have on the impression of an audience, the study employs a computer-aided content analysis of factual narcissistic and humble CEOs, identified via a video metric approach, and their evaluation through three key journalistic intermediaries (New York Times, Washington Post, and Financial Times). The quantitative data suggest that actual CEO narcissism is related negatively to external performance evaluations of CEOs in subsequent years. In addition, the data suggest that narcissism as well as humility scores increase the emotional tone employed depending on the journalistic orientation of the media outlet. Humble CEOs receive on average more media attention than narcissistic CEOs yet this result is insignificant, providing limited evidence for a systematic (i.e., number of articles) bias across and within journalistic outlets towards either narcissistic or humble CEOs. This suggests that widely considered “quality” media outlets resist to portray CEO traits in an overly positive/negative light.
Adsorption of cadmium selenide clusters: A novel approach to enhance solar energy conversion using armchair graphene nanoribbons
Authors: Tran Thi Nhan , Nguyen Truc Anh , Anh Duy Nguyen Vo , Nguyen Truong Long , Dinh Van An , Schall Peter , Dang Minh Triet 
Published: March 2024

Tailoring the electronic, optical, and transport properties of low-dimensional semiconductor materials is essential to improve the light-conversion efficiency of thin-film solar cell materials. Here, using first-principles calculations and non-equilibrium Green functions, we investigate the enhancement of optoelectronic and transport properties of armchair graphene nanoribbons (AGNRs) upon adsorption of cadmium selenide clusters. Upon adsorption of a CdSe diatomic molecule on an AGNR, the most energetically favorable configuration is the cadmium end sitting on top of a carbon atom. The corresponding electronic bandgap reduces ∼5 times with respect to that of the pristine system, thanks to the formation of a polaron state formed by the p-orbital of the selenide atom. Upon adsorption of CdSe cyclohexane molecules, the bandgap of this system slightly shrinks by 0.121 eV with respect to the pristine system. The charge accumulation induced by these clusters significantly enhances the absorption coefficient of the adsorbed systems, resulting in a red shift of the optical spectra toward the infrared region. More interestingly, by solving the Bethe–Salpeter equations with the Tamm–Dancoff approximation, we provide a direct link between the first-principles optical prediction and experimental observations. In addition, the electron transfer from these molecules to the hosted systems increases the transmission spectra in the vicinity of the Fermi level, leading to a remarkable electronic current passing through these scattering regions. These results highlight the role of cadmium selenide clusters in enhancing the light-to-energy conversion efficiency of next-generation solar cell devices.
Random forests for detecting weak signals and extracting physical information: A case study of magnetic navigation
Authors: Moradi Mohammadamin , Zhai Zheng-Meng , Nielsen Aaron , Lai Ying-Cheng 
Published: March 2024

It has been recently demonstrated that two machine-learning architectures, reservoir computing and time-delayed feed-forward neural networks, can be exploited for detecting the Earth’s anomaly magnetic field immersed in overwhelming complex signals for magnetic navigation in a GPS-denied environment. The accuracy of the detected anomaly field corresponds to a positioning accuracy in the range of 10–40 m. To increase the accuracy and reduce the uncertainty of weak signal detection as well as to directly obtain the position information, we exploit the machine-learning model of random forests that combines the output of multiple decision trees to give optimal values of the physical quantities of interest. In particular, from time-series data gathered from the cockpit of a flying airplane during various maneuvering stages, where strong background complex signals are caused by other elements of the Earth’s magnetic field and the fields produced by the electronic systems in the cockpit, we demonstrate that the random-forest algorithm performs remarkably well in detecting the weak anomaly field and in filtering the position of the aircraft. With the aid of the conventional inertial navigation system, the positioning error can be reduced to less than 10 m. We also find that, contrary to the conventional wisdom, the classic Tolles–Lawson model for calibrating and removing the magnetic field generated by the body of the aircraft is not necessary and may even be detrimental for the success of the random-forest method.