bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring intention of undergraduate students to embrace chatbots: from the vantage point of Lesotho
Authors: Ayanwale Musa Adekunle , Molefi Rethabile Rosemary 
Published: March 2024

AbstractThe increasing prevalence of Fourth Industrial Revolution (4IR) technologies has led to a surge in the popularity of AI application tools, particularly chatbots, in various fields, including education. This research explores the factors influencing undergraduate students' inclination to embrace AI application tools, specifically chatbots, for educational purposes. Using an expanded diffusion theory of innovation framework, the study investigates the relationship between relative advantages, compatibility, trialability, perceived trust, perceived usefulness, perceived ease of use, and behavioral intention. Using a 7-point scale, a questionnaire was given to 842 undergraduate students to collect data. The analysis, conducted using SmartPLS 4.0.9.2 software with a covariance-based structural equation model, produced significant findings. The study confirms hypotheses related to the relative advantages, compatibility, trialability, perceived usefulness, and perceived trust associated with chatbots. Notably, students who perceive the benefits of chatbots show a strong intention to use them for academic purposes. The perception of compatibility between students and chatbots positively influences adoption intention, highlighting the importance of compatibility. Additionally, students who have the opportunity to trial chatbots are more likely to use them, emphasizing the significance of trialability. Interestingly, the study did not establish direct relationships between perceived usefulness, perceived ease of use, and behavioral intention. This suggests the presence of other influential factors or dynamics in the adoption of chatbots for educational purposes. These findings offer practical insights for students and contribute to the theoretical understanding of the diffusion theory of innovation. Future research can further explore these insights to unravel the complexities of chatbot adoption and facilitate the broader adoption of AI tools in educational settings.
An efficient protocol for quantifying catalase activity in biological samples
Authors: Hadwan Mahmoud Hussein , Alta’ee Abdulsamie Hassan , Mohammed Rawa M. , Hadwan Asad M. , Al-Kawaz Hawraa Saad , Al Talebi Zainab Abbas 
Published: March 2024

Abstract
Background
Catalase is an important enzyme that helps protect cells against oxidative stress. The current protocol presents a reliable method for measuring catalase (CAT) enzyme activity in biological systems using the CUPRAC-CAT method.

Methods
In the CUPRAC-CAT method, the component of the enzymatic reaction was incubated before adding the Cu(Nc)22+ reagent. The unreacted substrates reduced the Cu(II)-the neocuproine complex, resulting in the highly colored Cu(I)-neocuproine product, which could be detected spectrophotometrically at 450 nm. The negative correlation between catalase activity and the absorbance of the Cu(I)-neocuproine complex was examined. To assess the optimization of Cu(I)-neocuproine complex production, response surface methodology (RSM) was employed, specifically utilizing the Box–Behnken design (BBD). Additionally, the reliability of the newly developed protocol was confirmed through Bland–Altman analysis of catalase activity in paired samples, employing the peroxovanadate method.

Results
The novel method is just as accurate as the established standard; the correlation between the two methods was 0.99. The CUPRAC-CAT method is stable, sensitive, linear, reproducible, accurate, and selective and can be used for quantifying oxidative stress while measuring catalase activity in liver tissue homogenates.

Conclusions
This study has demonstrated a straightforward and dependable protocol for evaluating catalase activity. The protocol is free from interference and can be easily employed in scientific research, ensuring a high level of accuracy and precision. The CUPRAC-CAT method is an effective technique to monitor bacterial contamination. This method provides quick and reliable results that can help ensure food safety and prevent or address bacterial contamination.

Graphical abstract
Neurocognitive profiles in a community sample of children & adolescents: sociodemographic, behavioral and emotional correlates
Authors: Barakat Marc , Shamseddeen Wael , Hanna Elissa , Dirani Leyla Akoury , Brent David , Porta Giovanna , Maalouf Fadi T. 
Published: March 2024

Abstract
Objectives
We aim to investigate the association between cognitive profiles of children and adolescents, classified using latent class analysis and emotional, behavioral and sociodemographic factors in a community-based sample of children and adolescents.

Methods
The sample consists of 161 participants recruited from a nationally representative household sample of 1517 children and adolescents who participated in a national mental health survey. Participants and their parents completed the following scales: Strengths and Difficulties Questionnaire, Mood and Feelings Questionnaire, and Screen for Child Anxiety Related Emotional Disorders. Participants were then administered a battery of cognitive tests from the Cambridge Automated Neuropsychological Assessment Battery as well as the Wechsler Nonverbal Scale of Ability.

Results
Latent class analysis showed a 2-class model that was stable and had good entropy (0.837). Class 1 included 58 participants (36.0%), and Class 2 included 103 participants (64.0%). Participants belonging to Class 1 performed better than those in Class 2 on all cognitive tasks. Chances for belonging to a specific Class varied based on different sociodemographic, behavioral and emotional factors: older participants with higher Intellectual Quotient, higher parental educational level, lower reported hyperactivity and better-reported mood were more likely to belong to Class 1.

Conclusion
Our results show a tight correlation between different emotional, behavioral and sociodemographic variables on one hand and cognitive functioning in children and adolescents on the other hand. This supports the continuous need for an integrative approach when building norms for cognitive tests that account at the least for all these variables.
Who are vaccine champions and what implementation strategies do they use to improve adolescent HPV vaccination? Findings from a national survey of primary care professionals
Authors: Brewington Micaela K. , Queen Tara L. , Heisler-MacKinnon Jennifer , Calo William A. , Weaver Sandra , Barry Chris , Kong Wei Yi , Kennedy Kathryn L. , Shea Christopher M. , Gilkey Melissa B. 
Published: March 2024

Abstract
Background
Implementation science researchers often cite clinical champions as critical to overcoming organizational resistance and other barriers to the implementation of evidence-based health services, yet relatively little is known about who champions are or how they effect change. To inform future efforts to identify and engage champions to support HPV vaccination, we sought to describe the key characteristics and strategies of vaccine champions working in adolescent primary care.

Methods
In 2022, we conducted a national survey with a web-based panel of 2527 primary care professionals (PCPs) with a role in adolescent HPV vaccination (57% response rate). Our sample consisted of pediatricians (26%), family medicine physicians (22%), advanced practice providers (24%), and nursing staff (28%). Our survey assessed PCPs’ experience with vaccine champions, defined as health care professionals “known for helping their colleagues improve vaccination rates.”

Results
Overall, 85% of PCPs reported currently working with one or more vaccine champions. Among these 2144 PCPs, most identified the champion with whom they worked most closely as being a physician (40%) or nurse (40%). Almost all identified champions worked to improve vaccination rates for vaccines in general (45%) or HPV vaccine specifically (49%). PCPs commonly reported that champion implementation strategies included sharing information (79%), encouragement (62%), and vaccination data (59%) with colleagues, but less than half reported that champions led quality improvement projects (39%). Most PCPs perceived their closest champion as being moderately to extremely effective at improving vaccination rates (91%). PCPs who did versus did not work with champions more often recommended HPV vaccination at the earliest opportunity of ages 9–10 rather than later ages (44% vs. 33%, p < 0.001).

Conclusions
Findings of our national study suggest that vaccine champions are common in adolescent primary care, but only a minority lead quality improvement projects. Interventionists seeking to identify champions to improve HPV vaccination rates can expect to find them among both physicians and nurses, but should be prepared to offer support to more fully engage them in implementing interventions.
The Right Dose: Results of a Patient Advocate–Led Survey of Individuals With Metastatic Breast Cancer Regarding Treatment-Related Side Effects and Views About Dosage Assessment to Optimize Quality of Life
Authors: Loeser Anne , Kim Janice S. , Peppercorn Jeffrey , Burkard Mark E. , Niemierko Andrzej , Juric Dejan , Kalinsky Kevin , Rugo Hope , Glenn Lesley , Hodgdon Christine , Maues Julia , Johnson Sheila , Padron Natalia , Parekh Kimberly , Lustberg Maryam , Bardia Aditya 
Published: March 2024

PURPOSE Although patients with metastatic breast cancer (MBC) have been living longer with the advent of more effective treatments such as targeted therapy and immunotherapy, the disease remains incurable, and most patients will undergo therapy indefinitely. When beginning therapy, patients are typically prescribed dose often based upon the maximum tolerated dose identified in phase I clinical trials. However, patients' perspectives about tolerability and willingness to discuss individualized dosing of drugs upon initiation of a new regimen and throughout the course of treatment have not been comprehensively evaluated. METHODS Patient advocates and medical oncologists from the Patient-Centered Dosing Initiative (PCDI) developed a survey to ascertain the prevalence and severity of MBC patients' treatment-related side effects, the level of patient-physician communication, mitigation strategies, perception about the relative efficacy of higher versus lower doses, and willingness to discuss alternative dosing. The PCDI distributed the anonymous confidential online survey in August 2020 to individuals with self-reported MBC. RESULTS One thousand and two hundred twenty-one patients with MBC completed the survey. 86.1% (n = 1,051) reported experiencing at least one significant treatment-related side effect, and of these, 20.3% (n = 213) visited the emergency room/hospital and 43.2% (n = 454) missed at least one treatment. Nearly all patients with side effects (97.6%, n = 1,026) informed their doctor and 81.7% (n = 838) received assistance. Of the 556 patients given a dose reduction for side-effect mitigation, 82.6% (n = 459) reported relief. Notably, majority of patients (53.3%, n = 651) do not believe that higher dose is always more effective than lower dose, and 92.3% (n = 1,127) would be willing to discuss flexible dosing options with their physicians based upon personal characteristics to optimize quality of life. CONCLUSION Given that the majority of patients with MBC experienced at least one substantial treatment-related side effect and most patients given a dose reduction reported improvement, innovative dosage-related strategies are warranted to sustain and improve patients' well-being. Patient-physician discussions in which the patient's unique attributes and circumstances are assessed upon initiation of new treatment and throughout the course of therapy may facilitate the identification of the most favorable dose for each patient, and the majority of patients would be receptive to this approach.
Human Seminal Extracellular Vesicles Enhance Endometrial Receptivity Through Leukemia Inhibitory Factor
Authors: Wang Hanshu , Lin Yu , Chen Rongrong , Zhu Yu , Wang Hongqiang , Li Shengxian , Yu Lei , Zhang Kaishu , Liu Yujie , Jing Tao , Sun Fei 
Published: March 2024

Abstract
Seminal extracellular vesicles (EVs) contain different subgroups that have diverse effects on sperm function. However, the effect of seminal EVs—especially their subgroups—on endometrial receptivity is largely unknown. Here, we found that seminal EVs could be divided into high-density EVs (EV-H), medium density EVs, and low-density EVs after purification using iodixanol. We demonstrated that EV-H could promote the expression and secretion of leukemia inhibitor factor (LIF) in human endometrial cells. In EV-H–treated endometrial cells, we identified 1274 differentially expressed genes (DEGs). DEGs were enriched in cell adhesion and AKT and STAT3 pathways. Therefore, we illustrated that EV-H enhanced the adhesion of human choriocarcinoma JAr cell spheroids to endometrial cells through the LIF-STAT3 pathway. Collectively, our findings indicated that seminal EV-H could regulate endometrial receptivity through the LIF pathway, which could provide novel insights into male fertility.
A Rare Case of NUT Carcinoma of the Thyroid
Authors: Cadesky Adam , Schulman-Rosenbaum Rifka , Carter Amanda , Paul Elizabeth , Jaggi Shuchie 
Published: March 2024

Abstract
NUT carcinoma is an aggressive, poorly differentiated squamous cell carcinoma, defined by rearrangement of the NUTM1 (Nuclear Protein in Testis) gene. Diagnosis is challenging due to histologic similarities with other poorly differentiated tumors requiring advanced diagnostic techniques. There is no established treatment, and prognosis remains extremely poor. A 27-year-old woman without known medical history presented with a rapidly enlarging neck mass and compressive symptoms. Chemotherapy for presumed squamous cell carcinoma with a component of anaplastic thyroid cancer based on pathology was initiated. Next-generation sequencing revealed thyroid NUT carcinoma with high PD-L1 expression, prompting PD-1 targeted therapy. The patient expired shortly afterwards from progressive disease. NUT carcinoma of thyroid origin is an extremely rare disease. This case brings awareness to the disease, highlights the importance of advanced diagnostic techniques and complexities in managing patients with NUT carcinoma.
Carry-over effect of artificial light at night on daytime mating activity in an ecologically important detritivore, the amphipod Gammarus pulex
Authors: He Yuhan , Ganguly Anirban , Lindgren Susan , Quispe Laura , Suvanto Corinne , Zhao Kangshun , Candolin Ulrika 
Published: March 2024

ABSTRACT
Artificial light at night (ALAN) is a growing environmental problem influencing the fitness of individuals through effects on their physiology and behaviour. Research on animals has primarily focused on effects on behaviour during the night, whereas less is known about effects transferred to daytime. Here, we investigated in the lab the impact of ALAN on the mating behaviour of an ecologically important freshwater amphipod, Gammarus pulex, during both daytime and nighttime. We manipulated the presence of ALAN and the intensity of male–male competition for access to females, and found the impact of ALAN on mating activity to be stronger during daytime than during nighttime, independent of male–male competition. At night, ALAN only reduced the probability of precopula pair formation, while during the daytime, it both decreased general activity and increased the probability of pair separation after pair formation. Thus, ALAN reduced mating success in G. pulex not only directly, through effects on mating behaviour at night, but also indirectly through a carry-over effect on daytime activity and the ability to remain in precopula. These results emphasise the importance of considering delayed effects of ALAN on organisms, including daytime activities that can be more important fitness determinants than nighttime activities.
Extrapolative Uncertainty and Household Economic Behavior
Authors: Fermand Elyas , Kuhnen Camelia M. , Li Geng , Ben-David Itzhak 
Published: March 2024

We examine the uncertainty in households’ expectations regarding macroeconomic outcomes, namely inflation and the rate of nationwide home price growth. We document that people extrapolate from the instability of their personal and local environment when assessing the future volatility of these macroeconomic variables. Consequently, there are within-person spillovers in subjective uncertainty regarding different economic outcomes. This extrapolative behavior is more pronounced among lower-numeracy individuals, and it persists throughout the business cycle. People with more uncertain macroeconomic expectations are more likely to engage in precautionary behaviors regarding consumption and equity market exposure and are more concerned about credit market access. This paper was accepted by David Simchi-Levi, finance. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2023.00820 .
Impact of the COVID-19 pandemic on the use of an inpatient and community palliative care service
Authors: Doo Irene , Fischer Amanda , Griffin Alison , Good Phillip 
Published: March 2024

Background: The COVID-19 pandemic disrupted the usual provision of healthcare, changing models of care, clinical loads, service provision and patient behaviour. Aims: This study assesses the impact of COVID-19 on community and inpatient palliative care service provision. Methods: A retrospective audit and comparison of service use conducted over two defined periods, before and during the COVID-19 pandemic, 2019–2020. Findings: The community palliative care service had a 9% increase in referrals, with a lower proportion of referrals (2.4%) from subacute/palliative care hospitals during the COVID-19 pandemic. Provision of care during the pandemic included less face-to-face contact with patients (24.1% versus 30.2% before), and markedly more contact with patients via videoconference (2.1% versus 0.1% before the pandemic). Conclusion: The community specialist palliative care service was busier during the pandemic period, and experienced a shift in mode of care delivery, while the inpatient unit experienced no difference in service use.
Chemosensory changes during chemotherapy
Authors: Mohamed Mona Abed El-Rahman , Ibrahim Noha Mohammed Ibrahim , Elezaby Hanan Hassan , Shehab Mariam Sabry 
Published: March 2024

Background: Chemosensory changes that occur during chemotherapy can significantly impact food enjoyment, quality of life and recovery. Aim: To investigate chemosensory changes reported by oncology patients during chemotherapy. Methods: A mixed-method cross-sectional study design was used to explore 100 cancer patients’ experiences of chemosensory changes during chemotherapy. All patients completed a questionnaire assessing their taste and smell preferences. A purposive sample of 30 patients underwent a semi-structured interview to elicit their thoughts on their experienced chemosensory changes. Descriptive statistics and themes were examined. Findings: The mean age of the sample was 50.56 years, and the majority of participants were female. The most stated taste alteration was bitter, while altered food preferences were also commonly experienced. Furthermore, most patients experienced unpleasant odours around food, while some experienced these odours even when food was not present. Overall, five themes were identified: changes in taste, changes in smell, changes in social life, altered comfort and food preferences. Conclusion: Chemosensory changes related to cancer and its treatment impact a person's nutrient intake, food-related behaviours, quality of life and treatment response. Patients who experience chemotherapy-associated chemosensory changes require specialised nutritional therapy to increase their eating-related pleasure. As part of the nutritional assessment, chemosensory alterations should be evaluated regularly.
Labor curves based on cervical dilatation over time and their accuracy and effectiveness: A systematic scoping review
Authors: Huurnink Johanne Mamohau Egenberg , Blix Ellen , Hals Elisabeth , Kaasen Anne , Bernitz Stine , Lavender Tina , Ahlberg Mia , Øian Pål , Høifødt Aase Irene , Miltenburg Andrea Solnes , Pay Aase Serine Devold 
Published: March 2024

Objectives
This systematic scoping review was conducted to 1) identify and describe labor curves that illustrate cervical dilatation over time; 2) map any evidence for, as well as outcomes used to evaluate the accuracy and effectiveness of the curves; and 3) identify areas in research that require further investigation.

Methods
A three-step systematic literature search was conducted for publications up to May 2023. We searched the Medline, Maternity & Infant Care, Embase, Cochrane Library, Epistemonikos, CINAHL, Scopus, and African Index Medicus databases for studies describing labor curves, assessing their effectiveness in improving birth outcomes, or assessing their accuracy as screening or diagnostic tools. Original research articles and systematic reviews were included. We excluded studies investigating adverse birth outcomes retrospectively, and those investigating the effect of analgesia-related interventions on labor progression. Study eligibility was assessed, and data were extracted from included studies using a piloted charting form. The findings are presented according to descriptive summaries created for the included studies.

Results and implications for research
Of 26,073 potentially eligible studies, 108 studies were included. Seventy-three studies described labor curves, of which ten of the thirteen largest were based mainly on the United States Consortium on Safe Labor cohort. Labor curve endpoints were 10 cm cervical dilatation in 69 studies and vaginal birth in 4 studies. Labor curve accuracy was assessed in 26 studies, of which all 15 published after 1986 were from low- and middle–income countries. Recent studies of labor curve accuracy in high-income countries are lacking. The effectiveness of labor curves was assessed in 13 studies, which failed to prove the superiority of any curve. Patient-reported health and well-being is an underrepresented outcome in evaluations of labor curves. The usefulness of labor curves is still a matter of debate, as studies have failed to prove their accuracy or effectiveness.