bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incident Use of Hydroxychloroquine for the Treatment of Rheumatoid Arthritis and Systemic Lupus Erythematosus During the COVID‐19 Pandemic
Authors: Mercadé‐Besora Núria , Guo Yuchen , Du Mike , Li Xintong , Ramírez‐Anguita Juan Manuel , Moreno Alberto , Valente António , Villalobos Felipe , Cheng Iek Leng , Carrasco‐Ribelles Lucía A. , van Swieten Maaike M. H. , Merkelbach Manon , Magoya Mary , Lasalvia Paolo , Pericàs‐Pulido Pau , Berg Paul , Bosco‐Lévy Pauline , Lillini Roberto , Ribeiro Rogerio , Bagga Trinamjot Kaur , Ramella Vittoria , Khalid Sara , Mayer Miguel Angel , Leis Angela , Jödicke Annika M. , Burn Edward , Prieto‐Alhambra Daniel , Català Martí , Prats‐Uribe Albert 
Published: March 2024

ObjectiveWe studied whether the use of hydroxychloroquine (HCQ) for COVID‐19 resulted in supply shortages for patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).MethodsWe used US claims data (IQVIA PHARMETRICS® Plus for Academics [PHARMETRICS]) and hospital electronic records from Spain (Institut Municipal d'Assistència Sanitària Information System [IMASIS]) to estimate monthly rates of HCQ use between January 2019 and March 2022, in the general population and in patients with RA and SLE. Methotrexate (MTX) use was estimated as a control.ResultsMore than 13.5 million individuals (13,311,811 PHARMETRICS, 207,646 IMASIS) were included in the general population cohort. RA and SLE cohorts enrolled 135,259 and 39,295 patients, respectively, in PHARMETRICS. Incidence of MTX and HCQ were stable before March 2020. On March 2020, the incidence of HCQ increased by 9‐ and 67‐fold in PHARMETRICS and IMASIS, respectively, and decreased in May 2020. Usage rates of HCQ went back to prepandemic trends in Spain but remained high in the United States, mimicking waves of COVID‐19. No significant changes in HCQ use were noted among patients with RA and SLE. MTX use rates decreased during HCQ approval period for COVID‐19 treatment.ConclusionUse of HCQ increased dramatically in the general population in both Spain and the United States during March and April 2020. Whereas Spain returned to prepandemic rates after the first wave, use of HCQ remained high and followed waves of COVID‐19 in the United States. However, we found no evidence of general shortages in the use of HCQ for both RA and SLE in the United States.
Design of distributed event‐triggered states and unknown disturbances observers for time‐varying delay interconnected systems
Authors: Cong Huong Dinh 
Published: March 2024

SummaryThis article considers the problem of designing distributed event‐triggered states and unknown disturbances observers for a class of nonlinear interconnected systems where the local state vectors are affected by unknown delays and the nonlinear function satisfying the Lipschitz condition. Distributed observers are designed based on the local input vector and both the local and remote output vectors. Different from previously distributed observers for interconnected systems where the local and remote output vectors are updated continuously, the one in this article uses only information on the local and remote output vectors updating at triggering instants of proposed event‐triggered mechanisms. This indicates that the proposed method in this article is better than the existing ones in saving communication resources while still keeping an acceptable estimation performance. Sufficient conditions for the existence of the proposed distributed observers are established and are formed in a convex optimization problem which can be easily solved by using the MATLAB LMI Control Toolbox. Finally, a numerical example is given to confirm the effectiveness and advantages of the proposed method.
Noninvasive Tracking of Embryonic Cardiac Dynamics and Development with Volumetric Optoacoustic Spectroscopy
Authors: Hatami Maryam , Özbek Ali , Deán‐Ben Xosé Luís , Gutierrez Jessica , Schill Alexander , Razansky Daniel , Larin Kirill V. 
Published: March 2024

AbstractNoninvasive monitoring of cardiac development can potentially prevent cardiac anomalies in adulthood. Mouse models provide unique opportunities to study cardiac development and disease in mammals. However, high‐resolution noninvasive functional analyses of murine embryonic cardiac models are challenging because of the small size and fast volumetric motion of the embryonic heart, which is deeply embedded inside the uterus. In this study, a real time volumetric optoacoustic spectroscopy (VOS) platform for whole‐heart visualization with high spatial (100 µm) and temporal (10 ms) resolutions is developed. Embryonic heart development on gestational days (GDs) 14.5–17.5 and quantify cardiac dynamics using time‐lapse‐4D image data of the heart is followed. Additionally, spectroscopic recordings enable the quantification of the blood oxygenation status in heart chambers in a label‐free and noninvasive manner. This technology introduces new possibilities for high‐resolution quantification of embryonic heart function at different gestational stages in mammalian models, offering an invaluable noninvasive method for developmental biology.
Depression and associated risk factors among emergency medicine interns: Results from a national longitudinal cohort study
Authors: Folk Destiny D. , Brown Cortlyn , Bissell Carrie C. , Fowler Lauren A. 
Published: March 2024

AbstractObjectiveDespite depression being common in residents, there are no published studies on the prevalence and risk factors for depression in emergency medicine (EM) interns. Our objectives were to explore the prevalence of depression among EM interns and to identify risk factors for depression including sleep, work hours, rotation type, race, ethnicity, sex, and age.MethodsThe Intern Health Study is a national longitudinal cohort study on intern mental health in all specialties. Secondary analysis was performed for EM interns only in this study. Data were collected from 2007 to 2021 and study participants completed a pre–intern year baseline survey and quarterly surveys throughout intern year, which included demographics and information on depressive symptoms, work hours, sleep, and rotation specifics. Depression severity was objectified using the Patient Health Questionnaire (PHQ9) with scores of 10 and higher meeting criteria for moderate to severe depression.ResultsA total of 1123 EM interns completed all surveys. The prevalence of moderate to severe depression among EM interns before starting internship was 4.8%. At Months 3, 6, 9, and 12 of intern year, the prevalence of moderate to severe depression was 17.8%, 20.5%, 20.8%, and 18.8%, respectively. PHQ9 scores were significantly higher at Month 3 of intern year compared to pre–intern year, but there were no differences at subsequent time points during intern year (p < 0.001). Females were more likely to have PHQ9 scores of 10 or above at all time points (p < 0.001). Clinical rotation type had a significant effect on PHQ9 scores, with intensive care unit rotations having a significantly higher PHQ9 score than other rotations (p < 0.001). Pearson's correlation revealed significant weak positive correlations between work hours and PHQ9 at each time point (r = 0.195, 0.200, 0.202, 0.243) and significant weak negative correlations between sleep hours and time off with PHQ9 (−0.162, −0.223, −0.180, −0.178; all p < 0.001).ConclusionsMany EM interns experience moderate to severe depression. Female EM interns are more likely to be depressed than male interns. Numerous factors influence depression scores for interns, many of which are modifiable.
C─H···π interaction induced H‐aggregates for wide range water content detection in organic solvents
Authors: Xu Jiajun , Huang Meifen , Pang Haijun , Weng Zhehui , Hu Guangzhi , Zhang Siman , Yang Qiuling , Wu Qiong 
Published: March 2024

AbstractJ‐aggregation and H‐aggregation are identified as two classical models of functionally oriented non‐covalent interactions, and significant attention has been drawn by researchers. However, due to the scarcity of single‐crystal examples of H‐aggregation, a comprehensive understanding of the relationship between its stacking mode and optical behaviour has been hindered. In recent studies, two polyaromatic Schiff base compounds, Cl‐Salmphen and H‐Salmphen, were successfully synthesized, and both were found to exhibit H‐aggregation. In the findings, H‐Salmphen was shown to display typical C─H···π interactions, characteristic of Aggregation‐Induced Emission (AIE) active molecules, whereas its halogenated counterpart was identified as behaving similar to Aggregation‐Caused Quenching (ACQ) active molecules. These types of results suggest that identical intermolecular interactions can produce differing optical behaviours. Light was shed, at least in part, on the formation mechanisms of H‐type aggregates and their luminescence properties from these observations. Additionally, the high optical signal‐to‐noise ratio inherent to H‐aggregates was utilized for the exploration of water content detection. As an outcome, a high‐performance fluorescent filter paper was developed, enabling easy real‐time detection using a smartphone.
Treatment of unilateral olfactory neuroblastoma: Appropriate extent of surgical resection and potential for olfactory preservation
Authors: Dharmarajan Harish , Choby Garret , Abi Hachem Ralph , Kuan Edward C. , Levine Corinna G. , Sanusi Olabisi , Schuman Theodore , Tang Dennis , Yim Michael , Geltzeiler Mathew 
Published: March 2024

AbstractHistorically, comprehensive surgical resection for olfactory neuroblastoma has included the bilateral olfactory epithelium, cribriform plate, overlying dura, olfactory bulbs and tracts. This results in postoperative anosmia that may significantly impact a patient's quality of life without definitive added benefit in survival. The prevalence of occult intracranial disease is low, especially for Hyams grade I and II tumors. A unilateral approach sparing the contralateral cribriform plate and olfactory system can be considered for select cases of early stage, low‐grade tumors when the disease does not cross midline to involve the contralateral olfactory cleft or septal mucosa and when midline dural margins can be cleared with frozen pathology. Approximately half of patients who undergo unilateral resection may have residual olfaction even with adjuvant unilateral radiation. Early data suggest favorable disease‐free survival and overall survival for patients who underwent the unilateral approach; however, larger sample studies are needed to confirm comparability to bilateral resections regarding oncologic outcomes.
A Tandem‐Locked Chemiluminescent Probe for Imaging of Tumor‐Associated Macrophage Polarization
Authors: Huang Jingsheng , Xu Mengke , Cheng Penghui , Yu Jie , Wu Jiayan , Pu Kanyi 
Published: March 2024

AbstractTumor‐associated macrophages (TAMs) play a role in both pro‐ and anti‐tumor functions; and the targeted polarization from M2 to M1 TAMs has become an effective therapy option. Although detection of M1 TAMs is imperative to assess cancer immunotherapeutic efficacy, existing optical probes suffer from shallow tissue penetration depth and poor specificity toward M1 TAMs. Herein, we report a tandem‐locked NIR chemiluminescent (CL) probe for specific detection of M1 TAMs. Through a combined molecular engineering approach via both atomic alternation and introduction of electron‐withdrawing groups, near‐infrared (NIR) chemiluminophores are screened out to possess record‐long emission (over 800 nm), record‐high CL quantum yield (2.7 % einstein/mol), and prolonged half‐life (7.7 h). Based on an ideal chemiluminophore, the tandem‐locked probe (DPDGN) is developed to only activate CL signal in the presence of both tumour (γ‐glutamyl transpeptidase) and M1 macrophage biomarkers (nitric oxide). Such a tandem‐lock design ensures its high specificity towards M1 macrophages in the tumor microenvironment over those in normal tissues or peripheral blood. Thus, DPDGN permits noninvasive imaging and tracking of M1 TAM in the tumor of living mice during R837 treatment, showing a good correlation with ex vivo methods. This study not only reports a new molecular approach towards highly efficient chemiluminophores but also reveals the first tandem‐locked CL probes for enhanced imaging specificity.
Multipolar Conjugated Polymer Framework Derived Ionic Sieves via Electronic Modulation for Long‐Life All‐Solid‐State Li Batteries
Authors: Yang Xue , Fang Long , Li Jing , Liu Cong , Zhong Linfeng , Yang Fan , Wang Xiaotong , Zhang Zishou , Yu Dingshan 
Published: March 2024

AbstractHere, we build a tunable multipolar conjugated polymer framework platform via pore wall chemistry to probe the role of electronic structure engineering in improving the Li+ conduction by theoretical studies. Guided by theoretical prediction, we develop a new cyano‐vinylene‐linked multipolar polymer framework namely CNF‐COF, which can act as efficient ion sieves to modify solid polymer electrolytes to simultaneously tune Li+ migration and stable Li anodes for long‐lifespan all‐solid‐state (ASS) Li metal batteries at high rate. The dual‐decoration of cyano and fluorine groups in CNF‐COF favorably regulates electronic structure via multipolar donor‐acceptor electronic effects to afford proper energy band structure and abundant electron‐rich sites for enhanced oxidative stability, facilitated ion‐pair dissociation and suppressed anion movements. Thus, the CNF‐COF incorporation into poly (ethylene oxide) (PEO) electrolytes not only renders fast selective Li+ transport but also facilitates the Li dendrite suppression. Specifically, the constructed PEO composite electrolyte with an ultra‐low CNF‐COF content of only 0.5 wt % is endowed with a wide electrochemical window, a high ionic conductivity of 0.634 mS cm−1 at 60 °C and a large Li+ transference number of 0.81—remarkably outperforming CNF‐COF‐free counterparts (0.183 mS cm−1 and 0.22). As such, the Li symmetric cell delivers stable Li plating/stripping over 1400 h at 0.1 mA cm−2. Impressively, by coupling with LiFePO4 (LFP) cathodes, the assembled ASS Li battery under 60 °C allows for stable cycling over 2000 cycles at 1 C and over 1000 cycles even at 2 C with a large capacity retention of ~75 %, surpassing most reported ASS Li batteries using PEO‐based electrolytes.
Non‐halogenated Solvent‐Processed Organic Solar Cells with Approaching 20 % Efficiency and Improved Photostability
Authors: Song Jiali , Zhang Chen , Li Chao , Qiao Jiawei , Yu Jifa , Gao Jiaxin , Wang Xunchang , Hao Xiaotao , Tang Zheng , Lu Guanghao , Yang Renqiang , Yan He , Sun Yanming 
Published: March 2024

AbstractThe development of high‐efficiency organic solar cells (OSCs) processed from non‐halogenated solvents is crucially important for their scale‐up industry production. However, owing to the difficulty of regulating molecular aggregation, there is a huge efficiency gap between non‐halogenated and halogenated solvent processed OSCs. Herein, we fabricate o‐xylene processed OSCs with approaching 20 % efficiency by incorporating a trimeric guest acceptor named Tri‐V into the PM6:L8‐BO‐X host blend. The incorporation of Tri‐V effectively restricts the excessive aggregation of L8‐BO‐X, regulates the molecular packing and optimizes the phase‐separation morphology, which leads to mitigated trap density states, reduced energy loss and suppressed charge recombination. Consequently, the PM6:L8‐BO‐X:Tri‐V‐based device achieves an efficiency of 19.82 %, representing the highest efficiency for non‐halogenated solvent‐processed OSCs reported to date. Noticeably, with the addition of Tri‐V, the ternary device shows an improved photostability than binary PM6:L8‐BO‐X‐based device, and maintains 80 % of the initial efficiency after continuous illumination for 1380 h. This work provides a feasible approach for fabricating high‐efficiency, stable, eco‐friendly OSCs, and sheds new light on the large‐scale industrial production of OSCs.
Single‐Molecule Characterization and Super‐Resolution Imaging of Alzheimer's Disease‐Relevant Tau Aggregates in Human Samples
Authors: Böken Dorothea , Cox Dezerae , Burke Melanie , Lam Jeff Y. L. , Katsinelos Taxiarchis , Danial John S. H. , Fertan Emre , McEwan William A. , Rowe James B. , Klenerman David 
Published: March 2024

AbstractHyperphosphorylation and aggregation of the protein tau play key roles in the development of Alzheimer's disease (AD). While the molecular structure of the filamentous tau aggregates has been determined to atomic resolution, there is far less information available about the smaller, soluble aggregates, which are believed to be more toxic. Traditional techniques are limited to bulk measures and struggle to identify individual aggregates in complex biological samples. To address this, we developed a novel single‐molecule pull‐down‐based assay (MAPTau) to detect and characterize individual tau aggregates in AD and control post‐mortem brain and biofluids. Using MAPTau, we report the quantity, as well as the size and circularity of tau aggregates measured using super‐resolution microscopy, revealing AD‐specific differences in tau aggregate morphology. By adapting MAPTau to detect multiple phosphorylation markers in individual aggregates using two‐color coincidence detection, we derived compositional profiles of the individual aggregates. We find an AD‐specific phosphorylation profile of tau aggregates with more than 80 % containing multiple phosphorylations, compared to 5 % in age‐matched non‐AD controls. Our results show that MAPTau is able to identify disease‐specific subpopulations of tau aggregates phosphorylated at different sites, that are invisible to other methods and enable the study of disease mechanisms and diagnosis.
Parahydrogen‐Induced Polarization of 14N Nuclei
Authors: Salnikov Oleg G. , Trofimov Ivan A. , Bender Zachary T. , Trepakova Alexandra I. , Xu Jingyan , Wibbels Garrett L. , Shchepin Roman V. , Koptyug Igor V. , Barskiy Danila A. 
Published: March 2024

AbstractHyperpolarization techniques provide a dramatic increase in sensitivity of nuclear magnetic resonance spectroscopy and imaging. In spite of the outstanding progress in solution‐state hyperpolarization of spin‐1/2 nuclei, hyperpolarization of quadrupolar nuclei remains challenging. Here, hyperpolarization of quadrupolar 14N nuclei with natural isotopic abundance of >99 % is demonstrated. This is achieved via pairwise addition of parahydrogen to tetraalkylammonium salts with vinyl or allyl unsaturated moieties followed by a subsequent polarization transfer from 1H to 14N nuclei at high magnetic field using PH‐INEPT or PH‐INEPT+ radiofrequency pulse sequence. Catalyst screening identified water‐soluble rhodium complex [Rh(P(m‐C6H4SO3Na)3)3Cl] as the most efficient catalyst for hyperpolarization of the substrates under study, providing up to 1.3 % and up to 6.6 % 1H polarization in the cases of vinyl and allyl precursors, respectively. The performance of PH‐INEPT and PH‐INEPT+ pulse sequences was optimized with respect to interpulse delays, and the resultant experimental dependences were in good agreement with simulations. As a result, 14N NMR signal enhancement of up to 760‐fold at 7.05 T (corresponding to 0.15 % 14N polarization) was obtained.
A Sensitive Technique Unravels the Kinetics of Activation and Trans‐Cleavage of CRISPR‐Cas Systems
Authors: Feng Wei , Peng Hanyong , Zhang Hongquan , Weinfeld Michael , Le X. Chris 
Published: March 2024

AbstractActivation of the CRISPR‐Cas13a system requires the formation of a crRNA‐Cas13a ribonucleoprotein (RNP) complex and the binding of an RNA activator to the RNP. These two binding processes play a crucial role in the performance of the CRISPR‐Cas13a system. However, the binding kinetics remain poorly understood, and a main challenge is the lack of a sensitive method for real‐time measurements of the dynamically formed active CRISPR‐Cas13a enzyme. We describe here a new method to study the binding kinetics and report the rate constants (kon and koff) and dissociation constant (Kd) for the binding between Cas13a and its activator. The method is able to unravel and quantify the kinetics of binding and cleavage separately, on the basis of measuring the real‐time trans‐cleavage rates of the CRISPR‐Cas system and obtaining the real‐time concentrations of the active CRISPR‐Cas ternary complex. We further discovered that once activated, the Cas13a system operates at a wide range of temperatures (7–37 °C) with fast trans‐cleavage kinetics. The new method and findings are important for diverse applications of the Cas13a system, such as the demonstrated quantification of microRNA at ambient temperatures (e.g., 25 °C).
Human‐centered explainable artificial intelligence: An Annual Review of Information Science and Technology (ARIST) paper
Authors: Ridley Michael 
Published: March 2024

AbstractExplainability is central to trust and accountability in artificial intelligence (AI) applications. The field of human‐centered explainable AI (HCXAI) arose as a response to mainstream explainable AI (XAI) which was focused on algorithmic perspectives and technical challenges, and less on the needs and contexts of the non‐expert, lay user. HCXAI is characterized by putting humans at the center of AI explainability. Taking a sociotechnical perspective, HCXAI prioritizes user and situational contexts, preferences reflection over acquiescence, and promotes the actionability of explanations. This review identifies the foundational ideas of HCXAI, how those concepts are operationalized in system design, how legislation and regulations might normalize its objectives, and the challenges that HCXAI must address as it matures as a field.
Yb‐TCPP metal–organic framework as fluorescence sensor for detecting tetracycline in milk
Authors: Zhang Ximan , Zhang Yun , Zhao Lina 
Published: March 2024

AbstractDeveloping effective means for detecting contamination in milk during production, processing, and storage is both important and challenging. Tetracycline (TC), due to its use in treating animal infections, is among the most prevalent organic pollutants in milk, posing potential and significant threats to human health. However, efficient and in situ monitoring of TC remains lacking. Nevertheless, we have successfully developed a highly sensitive and selective fluorescence method for detecting TC in milk using a metal–organic framework material made from Yb‐TCPP (ytterbium‐tetra(4‐carboxyphenyl)porphyrin). The calculated Stern–Volmer constant (KSV) was 12,310.88 M−1, and the detection limit was 2.44 × 10−6 M, surpassing previous reports. Crucially, Yb‐TCPP fluoresces in the near‐infrared region, promising its development into a specific fluorescence detection product for practical TC detection in milk, offering potential application value.