bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urinary Proteomics and Outcomes in Heart Failure With Preserved Ejection Fraction
Authors: Carland Corinne , Zhao Lei , Salman Oday , Cohen Jordana B. , Zamani Payman , Xiao Qing , Dongre Ashok , Wang Zhaoqing , Ebert Christina , Greenawalt Danielle , van Empel Vanessa , Richards A. Mark , Doughty Robert N. , Rietzschel Ernst , Javaheri Ali , Wang Yixin , Schafer Peter H. , Hersey Sarah , Carayannopoulos Leonidas N. , Seiffert Dietmar , Chang Ching‐Pin , Gordon David A. , Ramirez‐Valle Francisco , Mann Douglas L. , Cappola Thomas P. , Chirinos Julio A. 
Published: April 2024

Background
Although several studies have addressed plasma proteomics in heart failure with preserved ejection fraction, limited data are available on the prognostic value of urinary proteomics. The objective of our study was to identify urinary proteins/peptides associated with death and heart failure admission in patients with heart failure with preserved ejection fraction.

Methods and Results

The study population included participants enrolled in TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial). The relationship between urine protein levels and the risk of death or heart failure admission was assessed using Cox regression, in both nonadjusted analyses and adjusting for urine creatinine levels, and the MAGGIC (Meta‐Analysis Global Group in Chronic Heart Failure) score. A total of 426 (12.4%) TOPCAT participants had urinary protein data and were included. There were 40 urinary proteins/peptides significantly associated with death or heart failure admission in nonadjusted analyses, 21 of which were also significant adjusted analyses. Top proteins in the adjusted analysis included ANGPTL2 (angiopoietin‐like protein 2) (hazard ratio [HR], 0.5731 [95% CI, 0.47–0.7];
P
=3.13E‐05), AMY2A (α amylase 2A) (HR, 0.5496 [95% CI, 0.44–0.69];
P
=0.0001), and DNASE1 (deoxyribonuclease‐1) (HR, 0.5704 [95% CI, 0.46–0.71];
P
=0.0002). Higher urinary levels of proteins involved in fibrosis (collagen VI α‐1, collagen XV α‐1), metabolism (pancreatic α‐amylase 2A/B, mannosidase α class 1A member 1), and inflammation (heat shock protein family D member 1, inducible T cell costimulatory ligand) were associated with a lower risk of death or heart failure admission.

Conclusions
Our study identifies several novel associations between urinary proteins/peptides and outcomes in heart failure with preserved ejection fraction. Many of these associations are independent of clinical risk scores and may aid in risk stratification in this patient population.
Temporal Trends, Outcomes, and Predictors of Next‐Day Discharge and Readmission Following Uncomplicated Evolut Transcatheter Aortic Valve Replacement: A Propensity Score–Matched Analysis
Authors: Batchelor Wayne B. , Sanchez Carlos E. , Sorajja Paul , Harvey James E. , Galper Benjamin Z. , Kini Anapoorna , Keegan Patricia , Grubb Kendra J. , Eisenberg Ruth , Rogers Toby 
Published: April 2024

Background
Next‐day discharge (NDD) outcomes following uncomplicated self‐expanding transcatheter aortic valve replacement have not been studied. Here, we compare readmission rates and clinical outcomes in NDD versus non‐NDD transcatheter aortic valve replacement with Evolut.

Methods and Results

Society of Thoracic Surgeons/American College of Cardiology TVT (Transcatheter Valve Therapy) Registry patients (n=29 597) undergoing elective transcatheter aortic valve replacement with self‐expanding supra‐annular valves (Evolut R, PRO, and PRO+) from July 2019 to June 2021 were stratified by postprocedure length of stay: ≤1 day (NDD) versus >1 day (non‐NDD). Propensity score matching was used to compare risk adjusted 30‐day readmission rates and 1‐year outcomes in NDD versus non‐NDD, and multivariable regression to determine predictors of NDD and readmission. Between the first and last calendar quarter, the rate of NDD increased from 45.4% to 62.1% and median length of stay decreased from 2 days to 1. Propensity score matching produced relatively well‐matched NDD and non‐NDD cohorts (n=10 549 each). After matching, NDD was associated with lower 30‐day readmission rates (6.3% versus 8.4%;
P
<0.001) and 1‐year adverse outcomes (death, 7.0% versus 9.3%; life threatening/major bleeding, 1.6% versus 3.4%; new permanent pacemaker implantation/implantable cardioverter‐defibrillator, 3.6 versus 11.0%; [all
P
<0.001]). Predictors of NDD included non‐Hispanic ethnicity, preexisting permanent pacemaker implantation/implantable cardioverter‐defibrillator, and previous surgical aortic valve replacement.

Conclusions
Most patients undergoing uncomplicated self‐expanding Evolut transcatheter aortic valve replacement are discharged the next day. This study found that NDD can be predicted from baseline patient characteristics and was associated with favorable 30‐day and 1‐year outcomes, including low rates of permanent pacemaker implantation and readmission.
Detection of Epicardial Connection Through Intercaval Bundle Involving Right Pulmonary Veins After Ipsilateral Circumferential Ablation by Intra‐Atrial Activation Sequence Pacing From the Right Pulmonary Vein
Authors: Chikata Akio , Kato Takeshi , Usuda Kazuo , Fujita Shuhei , Usuda Keisuke , Kanatani Mao , Maruyama Michiro , Otowa Kan‐ichi , Kusayama Takashi , Tsuda Toyonobu , Hayashi Kenshi , Takamura Masayuki 
Published: April 2024

Background
An epicardial connection (EC) through the intercaval bundle (EC‐ICB) between the right pulmonary vein (RPV) and right atrium (RA) is one of the reasons for the need for carina ablation for PV isolation and may reduce the acute and chronic success of PV isolation. We evaluated the intra‐atrial activation sequence during RPV pacing after failure of ipsilateral RPV isolation and sought to identify specific conduction patterns in the presence of EC‐ICB.

Methods and Results

This study included 223 consecutive patients who underwent initial catheter ablation of atrial fibrillation. If the RPV was not isolated using circumferential ablation or reconnected during the waiting period, an exit map was created during mid‐RPV carina pacing. If the earliest site on the exit map was the RA, the patient was classified into the EC‐ICB group. The exit map, intra‐atrial activation sequence, and RPV‐high RA time were evaluated. First‐pass isolation of the RPV was not achieved in 36 patients (16.1%), and 22 patients (9.9%) showed reconnection. Twelve and 28 patients were classified into the EC‐ICB and non‐EC‐ICB groups, respectively, after excluding those with multiple ablation lesion sets or incomplete mapping. The intra‐atrial activation sequence showed different patterns between the 2 groups. The RPV‐high RA time was significantly shorter in the EC‐ICB than in the non‐EC‐ICB group (69.2±15.2 versus 148.6±51.2 ms;
P
<0.001), and RPV‐high RA time<89.0 ms was highly predictive of the existence of an EC‐ICB (sensitivity, 91.7%; specificity, 89.3%).

Conclusions
An EC‐ICB can be effectively detected by intra‐atrial sequencing during RPV pacing, and an RPV‐high RA time of <89.0 ms was highly predictive.
Motherhood and Domestic Authority in British and Colonial Quakerism, c.1650–1775
Authors: Pullin Naomi 
Published: April 2024

Abstract
This article explores how women, as mothers, acquired international influence within British and North American Quakerism between 1650 and 1775. It has been well established that Quakerism disrupted traditional domestic hierarchies, but less is known about the ways in which maternity provided agency for female Quakers in their everyday lives. This article focuses on the labors and experiences of women who did not undertake transatlantic travel, whose lives were primarily centered around raising their children and supporting the Quaker community. It shows how the evolving Religious Society of Friends enhanced the status of mothers in important ways, enabling women’s “reproductive labor” to be the subject of veneration and recognition. Using the journals and writings of traveling ministers, as well as correspondence exchanged between ministers, their hosts, and other members of the Society of Friends, it shows how women’s domestic roles provided a vital function for the transatlantic Quaker community.
Dewey, Adorno, and Pragmatist Aesthetics
Authors: Schulenberg Ulf 
Published: April 2024

Abstract
Pragmatist aesthetics has not yet reached its full potential. This is primarily due to the legacy of John Dewey’s aesthetics. In order to confront the shortcomings and insufficiencies of his aesthetics, pragmatist aestheticians ought to establish a dialogue with continental aesthetics. The attempt to clarify what pragmatist aesthetics can learn from Theodor W. Adorno’s materialist aesthetics is still a desideratum. This essay focuses on two aspects. First, it shows that pragmatist aestheticians can use Adorno’s modern aesthetics in order to gain a deeper and more complex understanding of the social nature or register of form (of what might be termed “die Gesellschaftlichkeit der Form”). Second, the essay demonstrates that Adorno, in contrast to Dewey, is valuable for the endeavor to grasp the significance of the dialectics of harmony and dissonance or organicity and fragmentation when analyzing modern art and literature.
Contingency without Rorty. Dewey and Addams on Art as Resistant Reconstruction
Authors: Ramazzotto Nicola 
Published: April 2024

Abstract
The purpose of this paper is to address Rorty’s critique of Dewey’s notion of experience and to reaffirm a view in which the call to experience is indispensable for a genuinely contingent philosophy. In the first part, I analyze Rorty’s critique of Dewey and show its inconsistency. In the second part, I draw a comparison between their aesthetic views and argue that a true aesthetic experience must consist in the cultivation and creative transfiguration of situational resistances. In the third part, using Jane Addams as an example, I illustrate how at Hull House the resistances provided by the situation were transfigured into original and meaningful aesthetic experiences that touched people’s lives and allowed for a meaningful and intelligent reconstruction.
How Can Regional Cooperation Help the Enhancement of Regional Economic Development and Strengthen the Voices of Developing Countries in Global Tax Negotiations?
Authors: Mosquera Valderrama Irma 
Published: April 2024

Abstract
The aims of this article are two-fold. First to provide a mapping of the regional initiatives and organizations and their link to regional tax cooperation and development. Second, to analyse how the existing regional cooperation initiatives and organizations can help to enhance regional economic development and to strengthen the voices of developing countries in international tax negotiations. This article concludes that the proliferation of memberships and organizations may be an obstacle to achieve regional economic development. Countries may want to participate in several agreements which may have the same or similar objectives, and in some cases, to withdraw from one or another, in order to focus on another agreement. The mapping of regional initiatives shows that more coordination is needed in order to strengthen the role of the regions in global tax negotiations not only at the BEPS Inclusive Framework but also at the United Nations level.
Keramat: Muḥammad’s Heirs and Nodes of a Multi-Centered Islam in Southeast Asia
Authors: Sevea Teren 
Published: April 2024

Abstract
Despite demographic realities, Muslim Southeast Asia remains one of the most marginalized regions in Islamic studies and in popular culture. This article grapples with one of the thorniest of allegations against the Islam of the “peripheries,” that the prevalence of saints and miracle workers, known as keramat in Southeast Asia, is nominally Islamic or syncretic and, thus, it is evidence of regional communities being “less-than-pure” Islamic. In doing so, this article analyzes the texts and traditions of keramat, focusing on Southeast Asian Islamic literature produced in Malay and Tamil from the late nineteenth century to the present. What emerges from a study of these texts, as well as of ongoing Islamic religious practices in the region, is a self-perception of Southeast Asian islands and cities as centers of Islam shaped by the network and circulation of keramat and ʿulamāʾ that operated as nodes of a multi-centered Islam. Arguing against attempts to flatten and essentialize Islam, Southeast Asian Islamic literature associated keramat with Muḥammad, highlighting how regional Islam and its rituals, liturgies, and ṭarīqa were directly passed down by the Prophet. Keramat texts emphasize that Southeast Asia’s saints and ʿulamāʾ were heirs of Muḥammad and enforcers of Muḥammad’s norms through bloodlines and other forms of intimacy. These texts, moreover, propose that some of the keramat buried in the region were the most consummate of Sufis, the Quṭb, or eschatological restorers, or Mahdi, and surpassed prophets in their miraculous powers. Overall, this is a story of miraculous narratives, devotional cultures, social memories, and sacral centers of the Islamic world that are often pushed to the peripheries of Islamic studies but refuse to be marginalized and forgotten.
Zarina’s Singularity: On Muslim Belonging and Unbelonging in the Modern World
Authors: Mian Ali Altaf 
Published: April 2024

Abstract
This article examines the predicament of Muslim identity in the modern world from the conceptual optics of singularity and unbelonging. These twin concepts are especially fleshed out in the artworks and interviews of Indian-American artist Zarina (1937–2020). Her words and works foreground what anti-colonial philosopher Leela Gandhi calls “minor globalism” and anti-identitarian belonging. Zarina thus highlights the ethics of singularity and the politics of unbelonging as alternatives to the two dominant models of the nation-state form in modern South Asia: composite nationalism and religious separatism. The article both contextualizes Zarina’s body of work in relation to the relevant theoretical conversations and relates the ethical and political implications of her minor globalism to Muslim identity discourses in modern South Asia.
Iqbal’s Falcons and Nightingales: Metaphor, Modernity, and the Poetics of Islam in South Asia
Authors: Chubb-Confer Francesca 
Published: April 2024

Abstract
Recent scholarship in Islamic studies has proposed ambiguity, especially in the form of literary metaphor and paradox, as integral to pre-modern Islam. However, literary ambiguity has also afforded an interpretive lens for articulations of modern Muslim identity. This article analyzes how two metaphors for the self – the nightingale and the falcon – function in Persian and Urdu ghazals of Muhammad Iqbal (d. 1938), for whom the resources of pre-modern Sufi poetry, especially ambiguity and paradox, become a method of meaning-making for the modern era. Iqbal’s use of these metaphors presents a nuanced view of the tensions between the inheritances of tradition and the demands of modernity for South Asian Muslims in the colonial era, and allows us to attend to the intersections of religion, literature, and politics in modern Islamic thought from the point of view of languages, genres, and geographies that remain marginal to the field of Islamic Studies.
Introduction: Centering Islamic Studies in Asia
Authors: Michael Jaclyn A. 
Published: April 2024

Abstract
This special issue explores historical and contemporary Asian Islamic traditions to offer an intentional grounding of Islamic studies in and as Asian Studies. Utilizing data from South, Southeast, and East Asian materials, the articles examine Islamic languages and literatures, socio-political institutions, legal practices, miracle workers and pilgrimage networks, and contemporary popular cultures. We build upon scholarship that represents global Islam as a civilizational process, a discursive tradition, a hermeneutic engagement, or as a cosmopolis. In drawing on Asian practices we reassess key categories, conclusions, and questions in the study of Islam such as the nature of Muslim centers and peripheries, the role of ambiguity in religious expression, the importance of the visual arts to identity formation, the gendered dimensions of legal authority and practice, the role of languages other than Arabic in constructing the Muslim community, and how modern Muslim welfare organizations and women’s pious fashion serve the aspirational goals of individuals and communities. Rectifying the legacies of colonialism and Orientalism in the marginalization of Asia in the study of Islam, we argue Islamic studies has much to learn from Asian perspectives and that Asia is an exceptional place from which the field can conceptualize Islamic traditions in broader terms.
Shikonin Attenuate Behavioral Defects, Oxidative Stress, and Neuroinflammation During Aluminum Chloride-induced Alzheimer’s Disease Condition in an in vivo Experimental Model
Authors: Li Danni , Wang Min 
Published: April 2024

Background Aluminum chloride (AlCl3) is an environmental neurotoxin that affects cerebral functions and causes health complications. However, the role of AlCl3 in arbitrating glia homeostasis and pathophysiology remains obscure. Objectives In this study, we analyzed the role of AlCl3 in causing reactive gliosis in the brain of rats and the ability of Shikonin to attenuate reactive gliosis and neuronal inflammation. Materials and Methods In our study, animals were divided into five different groups. The status of AlCl3-induced alterations in neurobehavioral status, estimation of acetylcholinesterase (AChE) and Aβ1 peptide in rat brain, oxidative stress (lipid peroxidation [LPO] and nitric oxide [NO]), antioxidant levels (superoxide dismutase [SOD], Catalase [CAT], and glutathione [GSH]), inflammatory marker levels (interleukin-1β [IL-1β], interleukin-6 [IL-6], and tumor necrosis factor-alpha [TNF-α]), and histopathological changes were analyzed and the neuroprotective effect of Shikonin investigated. Results Treatment with Shikonin significantly restored the changes in the open field test, Morris water maze test, and Y-maze spontaneous alteration test in Alzheimer’s disease (AD) rats induced by AlCl3. Shikonin treatment significantly reduced levels of AChE and Aβ1 peptide content in AD rat brain tissues induced with AlCl3. Furthermore, Shikonin treatment significantly reduced the levels of oxidative stress markers and restored the levels of endogenous antioxidants in AlCl3-induced AD rats. Levels of inflammatory cytokines were significantly reduced upon Shikonin treatment in AD rats induced with AlCl3. In accordance with the aforementioned benefits, treatment with Shikonin significantly restored the histological aberrations and infiltration of granular cells white blood cells (WBCs) in brain tissues of AD rats induced with AlCl3. Conclusion Collectively, our results showed that Shikonin significantly restored altered neurobehavioral changes and antioxidant levels, and reduced oxidative stress and the inflammatory milieu. Additionally, histological abnormalities support its neuroprotective effectiveness under experimentally induced Alzheimer’s disease conditions caused by AlCl3 in rats.
Clearing the Highest Hurdles: Intragroup Conflicts and Cooperation in Large Groups
Authors: Khandan Abbas 
Published: April 2024

The literature pessimistically predicts that large groups will fail in pursuing their common interests and blame free-riders in general. However, not all players outside the coalition are free-riders. In order to avoid intragroup conflicts, leaders of coalitions may create a kind of bureaucracy and exclude some players as well. Therefore, from the outsiders’ viewpoint, there is an agency problem as their preferences will not be considered by insiders. This study explores the conflict between coalition insiders and outsiders in a theoretical model and using the Coase theorem seeks a middle ground on which both sides can compromise. It shows that by designing a mechanism for indirect cooperation insiders and outsiders can reach a Pareto superior win-win solution that is efficient, saves on organizational costs, partly overcomes free-riding, and avoids agency problems and the under-provision of collective goods. The key to success is to design cooperation mechanisms in different but complete and compatible forms. Finally, real-world examples are provided showing how large groups can resolve their group conflicts by defining cooperation on a ‘continuum of collective action’. JEL: D7; D2; C7
GbyE: an integrated tool for genome widely association study and genome selection based on genetic by environmental interaction
Authors: Liu Xinrui , Wang Mingxiu , Qin Jie , Liu Yaxin , Wang Shikai , Wu Shiyu , Zhang Ming , Zhong Jincheng , Wang Jiabo 
Published: April 2024

Abstract
Background
The growth and development of organism were dependent on the effect of genetic, environment, and their interaction. In recent decades, lots of candidate additive genetic markers and genes had been detected by using genome-widely association study (GWAS). However, restricted to computing power and practical tool, the interactive effect of markers and genes were not revealed clearly. And utilization of these interactive markers is difficult in the breeding and prediction, such as genome selection (GS).

Results
Through the Power-FDR curve, the GbyE algorithm can detect more significant genetic loci at different levels of genetic correlation and heritability, especially at low heritability levels. The additive effect of GbyE exhibits high significance on certain chromosomes, while the interactive effect detects more significant sites on other chromosomes, which were not detected in the first two parts. In prediction accuracy testing, in most cases of heritability and genetic correlation, the majority of prediction accuracy of GbyE is significantly higher than that of the mean method, regardless of whether the rrBLUP model or BGLR model is used for statistics. The GbyE algorithm improves the prediction accuracy of the three Bayesian models BRR, BayesA, and BayesLASSO using information from genetic by environmental interaction (G × E) and increases the prediction accuracy by 9.4%, 9.1%, and 11%, respectively, relative to the Mean value method. The GbyE algorithm is significantly superior to the mean method in the absence of a single environment, regardless of the combination of heritability and genetic correlation, especially in the case of high genetic correlation and heritability.

Conclusions
Therefore, this study constructed a new genotype design model program (GbyE) for GWAS and GS using Kronecker product. which was able to clearly estimate the additive and interactive effects separately. The results showed that GbyE can provide higher statistical power for the GWAS and more prediction accuracy of the GS models. In addition, GbyE gives varying degrees of improvement of prediction accuracy in three Bayesian models (BRR, BayesA, and BayesCpi). Whatever the phenotype were missed in the single environment or multiple environments, the GbyE also makes better prediction for inference population set. This study helps us understand the interactive relationship between genomic and environment in the complex traits. The GbyE source code is available at the GitHub website (https://github.com/liu-xinrui/GbyE).