bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncovering Chemical Interactions between Danshen and Danggui Using Liquid Chromatography–Mass Spectrometry and Network Pharmacology-Based Research on Stroke
Authors: Pang Han-Qing , Guo Jia-Xiu , Shang Xiao-Yu , Wang Jian , Liu Hui , Tian Jing , Zhang Lu , Wang Jian-Bin , Shi Wei , Yan Bing-Chun , Liu Liang 
Published: April 2024

Abstract

Objective:
The objective of this study was to decipher chemical interactions between Danshen and Danggui using liquid chromatography–mass spectrometry (LC-MS) and explore the mechanisms of Danshen–Danggui against stroke using network pharmacology and molecular docking.

Materials and Methods:
First, the chemical compounds of Danshen–Danggui were profiled using ultra-high-performance liquid chromatography (HPLC)-quadrupole time-of-flight MS. Accurately characterized compounds in various proportions of Danshen–Danggui were quantified using HPLC combined with triple quadrupole electrospray tandem MS. Network pharmacology was used to uncover the essential mechanisms of action of Danshen–Danggui against stroke. Discovery Studio Software was used for the molecular docking verification of key active chemicals and stroke-related targets.

Results:
A total of 53 compounds were characterized, and 22 accurately identified constituents (10 phenolic acids, 8 phthalides, and 4 tanshinones) were quantified in 15 proportions of Danshen–Danggui. The quantification results showed that Danggui significantly increased the dissolution of most phenolic acids (compounds from Danshen), whereas Danshen promoted the dissolution of most phthalides (compounds from Danggui). Overall, the combination of Danshen and Danggui at a 1:1 ratio resulted in the maximum total dissolution rate. Further network pharmacology and molecular docking results indicated that Danshen–Danggui exerted anti-stroke effects mainly by regulating inflammation-related (tumor necrosis factor, hypoxia-inducible factor, and toll-like receptor) signaling pathways, which ranked among the top three pathways based on Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis.

Conclusion:
The chemical compounds in Danshen–Danggui could interact with each other to increase the dissolution of the most active compounds, which could provide a solid basis for uncovering the compatibility mechanisms of Danshen–Danggui and Danshen–Danggui-based formulae.
Compatibility with Fructus Ligustri Lucidi Effectively Mitigates Idiosyncratic Liver Injury of Epimedii Folium by Modulating NOD-like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation
Authors: Zhao Xiao-Mei , Wu Zhi-Xin , Wang Yan , Xu Ying-Jie , Xiu Ye , Dong Xu , Li Jun-Jie , Lv Gui-Ji , Wang Si-Hao , Li Yu-Rong , Bai Zhao-Fang , Xiao Xiao-He 
Published: April 2024

Abstract

Background:
Idiosyncratic drug-induced liver injury (IDILI) is a serious side effect of drugs, Epimedii Folium (EF) is unequivocally implicated in idiosyncratic liver injury onset, potentially due to its ability to perturb the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome. Fructus Ligustri Lucidi (FLL), a frequently used medicinal combination with EF, has not yet been investigated for its ability to ameliorate EF-associated hepatotoxicity.

Aims and Objectives:
Study on the mechanism of compatibility of FLL to alleviate liver injury caused by EF.

Materials and Methods:
Western blot was used to determine the expression of related proteins, ELISA was used to detect the secretion of related inflammatory factors IL-1β, IL-18, IL-6 and TNF-α, liver injury indexes were detected and liver pathological tissue staining was used to evaluate the liver injury.

Results:
Our results demonstrated that EF exerted a particular augmenting effect on the stimulation of the NLRP3 inflammasome mediated by nigericin or ATP, whereas FLL suppressed the NLRP3 inflammasome stimulation. Furthermore, an equal EF to FLL ratio significantly reduced the stimulatory effects of EF. Moreover, EF has the potential to induce hepatic injury and augment pro-inflammatory cytokine synthesis in rats subjected to LPS. However, when combined with FLL, the detrimental effects of EF were mitigated.

Conclusions:
FLL possesses the capacity to attenuate EF-associated hepatotoxicity by suppressing EF-triggered NLRP3 inflammasome activation. Thus, FLL holds promise for improving the clinical safety profile of EF, shedding light on the potential of compatibility and detoxification theories in traditional Chinese medicine.
Transversal family of non-autonomous conformal iterated function systems
Authors: Nakajima Yuto 
Published: April 2024

We study Non-autonomous Iterated Function Systems (NIFSs) with overlaps. A NIFS on a compact subset

X\subset\mathbb{R}^{m}

is a sequence

\Phi=(\{\phi^{(j)}_{i}\}_{i\in I^{(j)}})_{j=1}^{\infty}

of collections of uniformly contracting maps

\phi^{(j)}_{i}\colon X\rightarrow X

, where

I^{(j)}

is a finite set. In comparison to usual iterated function systems, we allow the contractions

\phi^{(j)}_{i}

applied at each step

j

to depend on

j

. In this paper, we focus on a family of parameterized NIFSs on

\mathbb{R}^{m}

. Here, we do not assume the open set condition. We show that if a

d

-parameter family of such systems satisfies the transversality condition, then for almost every parameter value the Hausdorff dimension of the limit set is the minimum of

m

and the Bowen dimension. Moreover, we give an example of a family

\{\Phi_{t}\}_{t\in U}

of parameterized NIFSs such that

\{\Phi_{t}\}_{t\in U}

satisfies the transversality condition but

\Phi_{t}

does not satisfy the open set condition for any

t\in U

.
Perancangan Aplikasi Similarity Deteksi Kemiripan Judul Disertasi Berbasis Web
Authors: Mayola Liga , Hafizh Muhammad , Putra Deri Marse 
Published: April 2024

Pendidikan memiliki tujuan dan sistem yang baik yaitu menciptakan generasi yang terpercaya secara tindakan dan tulisan ilmiah. seorang terdidik harus mempunyai etika dalam menulis karya, salah satunya dalah menghindari plagiarism. Menentukan judul disertasi yang akan di ajukan harus memperhatikan beberapa aspek agar terhindar dari kemiripan bahkan kesamaan judul karena mengambil tulisan atau gagasan seseorang tampa mencantumkan sumber adalah sebuah tindakan yang di larang di dalam etika karya ilmiah. untuk mencegah hal tersebut bisa dengan melakukan cek kemiripan judul yang bisa di lakukan dengan beberapa metode, salah satunya adalah algoritma jaccard similarity yaitu sebuah algoritma yang berfungsi untuk mencari kesamaan atau kemiripan suatu permasalahan, dengan perhitungan yang didalamnya memiliki rumus untuk pemecahan permasalahan. Sederhananya perhitungan algoritma ini akan ditambah dengan pembobotan nilai tertentu untuk menambah nilai persamaan kasus sebelumnya dengan kasus baru.[1]membandingkan judul per judul itu sangat memakan waktu jika di lakukan secara manual, oleh karena itu perancangan aplikasi perlu di lakukan agar nantinya dapat membantu pihak terkait dalam menentukan kemiripan judul disertasi. perancangan ini nantinya akan menjadi arahan dalam membangun aplikasi deteksi kemiripan judul desertasi dengan hasil persentasi kemiripan judul dengan tingkat minimum kemiripan yang dapat di terima adalah 10%, dan yang jadi pertimbangan 11% s/d 15%.
THE ROLE OF DIFFUSION-WEIGHTED IMAGING IN THE DIFFERENTIAL DIAGNOSIS OF LIVER LESIONS
Authors: Konukoglu O. , Tahtabasi M. , Boyaci F. N. , Karakas E. 
Published: April 2024

Introduction: Diffusion-weighted imaging [DWI] plays a significant role in distinguishing liver lesions. This study focuses on the significance of apparent diffusion coefficient [ADC] values in distinguishing between benign and malignant liver lesions.
Methods: A retrospective evaluation was conducted on patients who underwent liver MRI examinations at our clinic, and 378 liver lesions were found. The study comprised 141 women, 80 men, and 221 patients with liver lesions. The measured ADC values between benign and malignant lesions were compared. In addition, the lesion ADC value/CSF ADC value ratio was measured, and the relative ADC value was named.
Results: 118 hemangiomas, 59 simple cysts, 67 hydatid cysts, 3 focal nodular hyperplasias, 9 abscesses, 28 hepatocellular carcinomas, 88 metastases, and 6 lymphomas were evaluated. Simple cysts and hemangiomas had the most elevated ADC values compared to all other liver lesions. The ADC values for liver lesions classified as benign had a mean of 2.10 x 10-3 mm2/s, while malignant ones had a lower mean of 0.75 x 10-3 mm2/s. The ADC values of malignant liver lesions were lower compared to the benign lesions.
Conclusion: Using DWI combined with ADC values could be valuable in discerning between benign and malignant liver lesions. Besides, relative ADC values may also contribute to more objective results.
TREATMENT, DISEASE CONTROL, QUALITY OF LIFE AND PSYCHOLOGICAL STATUS IN PATIENTS WITH ANKYLOSING SPONDYLITIS DURING THE COVID-19 PANDEMIC
Authors: Tombak Y. , Sen A. E. , Sezer M. K. , Bal A. , Eksioglu E. , Dulgeroglu D. , Ercan Bati B. , Karaahmet O. Z. 
Published: April 2024

Introduction. The coronavirus disease (COVID-19) pandemic has the potential to impact disease activity and psychological well-being in people with rheumatic diseases. This study aimed to compare ankylosing spondylitis (AS) patients with and without COVID-19 history in terms of treatment, disease control, quality of life and psychological status by providing a cross-sectional look at treatment, disease control, quality of life and psychological status in patients with AS during the COVID-19 pandemic.
Methods. The study included 74 AS patients, in two groups based on COVID-19 history. Demographic data and clinical characteristics were recorded. Treatment, disease control, functional status, and quality of life were evaluated using Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index (BASFI), and impact of COVID-19 on quality-of-life scales. Psychological status was assessed using the Beck Depression Inventory, Beck Hopelessness Scale, and COVID-19 anxiety scale.
Results. Of the 74 patients diagnosed with AS, 44 were female and 34 were male. The mean age was 47.3 years. In total, 35 patients (47.3%) had COVID-19. We found that the group without COVID-19 had significantly higher levels of hypothyroidism than the other group (p = 0.008). The BASFI value was significantly higher in the COVID-19 group (p = 0.031). The group with COVID-19 had a substantially higher rate of continuing non-anti-rheumatic drug use than the other group (p = 0.02).
Conclusion. During COVID-19 pandemic period, the majority of patients continued their medication, so treatment and disease control were not negatively affected. Having COVID-19 did not cause a significant difference psychologically.
Global Versus Regional Carbon Taxation: Exploring a Natural Experiment
Authors: Herzog Bodo 
Published: April 2024

The reduction of global greenhouse gas (GHG) emissions is a priority due to climate change. Scientists across disciplines promote carbon taxation or carbon pricing as an instrument to mitigate the negative externality of fossil energies. We exhibit two insufficiencies of today’s regulatory policy by utilizing a novel natural experiment. First, carbon taxation is only effective if it is implemented on a global scale because fossil energy markets and emissions are cross-border and global. Second, carbon taxation is based on an extrinsic mechanism and does not alter intrinsic behavior sustainably. Our applied theory and modeling approach are corroborating these findings. The present regulatory approach is doomed to fail due to overambitious European countries and unambitious (partly realistic) rest of the world. Our interdisciplinary analysis unravels a new agenda to achieve the essential aim. What is needed is a global climate club, as proposed by Nobel Laureate William Nordhaus, with a least but global GHG reduction.

Received: 9 November 2023 | Revised: 16 January 2024 | Accepted: 3 April 2024

Conflicts of Interest
The author declares that he has no conflicts of interest to this work.

Data Availability Statement
The data that support the findings of this study are openly available. WTI oil price data are from FRED.org at https://fred.stlouisfed.org/. Data about global oil supply/demand are available by bp Statistical Review of World Energy June 2022 at https://www.bp.com/content/dam/bp/business-sites/en/global/corporate/pdfs/energy-economics/statistical-review/bp-stats-review-2022-full-report.pdf. Global CO2 emissions are from World in Data at https://ourworldindata.org/co2-emissions.

Author Contribution Statement
Bodo Herzog: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Resources, Data curation, Writing - original draft, Writing - review & editing, Visualization, Project administration.
Flood frequency analysis using mean daily flows vs. instantaneous peak flows
Authors: Bartens Anne , Shehu Bora , Haberlandt Uwe 
Published: April 2024

Abstract. In many cases, flood frequency analysis (FFA) needs to be carried out on mean daily flows (MDF) instead of instantaneous peak flows (IPF), which can lead to underestimation of design flows. Typically, correction methods are applied to the MDF data to account for such underestimation. In this study, we first analyse the error distribution of MDF-derived flood quantiles over 648 catchments in Germany. The results show that using MDF instead of IPF data can lead to underestimation of the mean annual peak flow (MHQ) by up to 80 % and mainly depends on the catchment area but appears to be influenced by gauge elevation as well. This relationship is shown to differ for summer vs. winter floods. To correct such underestimation, different linear models based on predictors derived from MDF hydrograph and catchment characteristics are investigated. Apart from the catchment area, a key predictor in these models is the event-based ratio of flood peak to flood volume (p/V ratio) obtained by the MDF data. The p/V models applied to either MDF-derived events or statistics seem to outperform other reference correction methods. Moreover, they require a minimum data input, are easily applied, and are valid for the entire study area. The best results are achieved when the L moments of the MDF maximum annual series are corrected with the proposed model, which reduces the flood quantile errors by up to 60 %. The approach behaves particularly well in smaller catchments (<500 km2), where reference methods fall short. However, the limit of the proposed approach is reached for catchment sizes under 100 km2, where the hydrograph information from the daily series is no longer capable of approximating instantaneous flood dynamics and gauge elevations below 100 m, where the difference between MDF and IPF floods is very small.
The Interrelation of Dialectic and Hermeneutics in Paul Ricœur’s Early Philosophy of the Self
Authors: Steinmetz Michael 
Published: April 2024

While Ricœur's œuvre is commonly known as hermeneutic philosophy, it is evident that he also deals with major problems dialectically - a discipline often put in opposition to hermeneutics. In this paper, I offer an interpretation of the relationship between dialectic and hermeneutic regarding Ricœur's early theory of the self, which he developed in the 1960s, beginning with the second volume of his Philosophie de la volonté, Finitude et Culpabilité. I argue that hermeneutic and dialectic refer to each other by combining a structural model of reflexive self-consciousness and a mediation of consciousness with a transcendent other. Only their interrelation allows for a sufficient theory of concrete reflexion.
Awareness About Solid Waste Management – A Study with Reference to Home Makers in Chennai
Authors: Dr. U. Kavitha, Dr. E. Subbulakshmi Dr. S. Vimaladevi, Dr. B.R. Celia, 
Published: April 2024

This study's objective is to evaluate the levels of knowledge and practices that are linked with the management of solid waste among homemakers in Chennai. Specifically, the research will focus on the city of Chennai. Managing garbage in an effective manner is becoming an urgent need for those who want to live a sustainable lifestyle. This is due to the fact that the population is expanding and the urbanisation rate is rising. This research evaluates the knowledge, of homemakers in regard to the disposal of garbage.
The ubiquitous waste management strategies that are used in households are investigated in this study, with a special emphasis placed on the role that homemakers play as key factors in shaping these practices. In this study, the grasp of concepts such as recycling, segregation of the solid waste, and the impact that improper waste disposal has on the environment is investigated. The purpose of the insights that were gathered from the study is to bring to light potential areas that may be improved via intervention and development.
The purpose of this awareness is to provide homemakers with the information they need to adopt waste management practices that are socially and ecologically responsible. This will ultimately result in a cleaner and greener Chennai. The findings of this study have the potential to serve as a valuable resource for residents, government, community, and environmental activists, therefore fostering a collective commitment to the implementation of responsible waste management practices.
Sport in the Cartoons of Charles Addams and Gary Larson: A Theater of Ludic Absurdity
Authors: Segrave Jeffrey O. , Cosgrove John A. 
Published: April 2024

ABSTRACT
This article examines how sport illuminates the Dadaist foundations of Charles Addams’s and Gary Larson’s humor in their single-panel cartoons. The article also considers how Addams’s and Larson’s treatment of sport sheds light on particular theories of humor and elucidates their view of sport as human endeavor and social institution. Ultimately, this article argues that Addams and Larson portray sport in a way that suggests that the appropriate mode by which to approach life may well be the comic and playful one that characterizes Zen Buddhism. While the sport cartoons of Addams and Larson constitute a theater of ludic absurdity, in the end, they also offer us liberating enlightenment.
Mark Twain’s Earworm
Authors: Scharnhorst Gary 
Published: April 2024

ABSTRACT
Mark Twain’s obsession with and popularization of Isaac Bromley’s original horsecar jingle not only inspired an entire school of horsecar poems but also parodies of them that satirized political campaigns, public corruption, organized labor, vices such as gambling and alcoholism, the work of newspaper editors as well as admonitions to respect the law. During the Great War, parodies of the jingle commended the women knitting brigades on the home front. The parodies also led to the introduction of jingles in advertising. The original rhyme has survived in the public imagination for generations.
Vom Durchwandern der Deduktion, Induktion und Abduktion
Authors: Wiesner Christian 
Published: April 2024

Der vorliegende Beitrag zeigt die Besonderheiten der Deduktion, Induktion und Abduktion als die wissenschaftlichen Schlussfolgerungen auf. Zunächst führt der Beitrag in eine Systematik ein, um wissenschaftliche Schlussfolgerungen im Sinne von Wege auf Landkarten darstellen zu können. Dazu dient eine kurze Einführung in die Bildpädagogik und die sich daraus entwickelnde Landkarte, um analog zu einer Wanderkarte die Denkbewegungen der Deduktion, Induktion und Abduktion nachvollziehbar zu machen. Danach werden die drei Schlussfolgerungen detailliert dargestellt, um deren jeweils spezifische Besonderheit hervorheben zu können. Jede Beschreibung der jeweiligen Schlussfolgerung wird eine dazu passende Landkarte enthalten und zugleich noch die Relationen der Denkbewegungen in einer Mengenbildlichkeit und in einer iterativen Zeichenbeziehung visualisieren. Damit entstehen neben einem traditionellen Wasserfallmodell von den Schlussformen zusätzliche bildpädagogische Darstellungen, um die Schlussformen gedanklich ‚durchwandern‘ zu können. Am Ende werden die Besonderheiten der Deduktion, Induktion und Abduktion in einem gemeinsamen Abschluss aufgezeigt.
Diálogo sobre el pensamiento médico social del Dr. Salvador Allende
Authors: Oyarce Ana María 
Published: April 2024

Se puede afirmar que las bases fundamentales que determinan el bienestar y el progreso de los pueblos son precisamente un buen estándar de vida, condiciones sanitarias adecuadas y amplia difusión de la cultura en los medios populares…el hombre en sociedad no es un ente abstracto: nace, se desarrolla, vive, trabaja, se reproduce, enferma y muere en sujeción estricta al ambiente que lo rodea.
Esa frase del Dr Salvador Allende G, escrita en 1939 en su obra la Realidad Médico Social Chilena, condensa el pensamiento médico social del Dr. Allende. Si bien fue plasmada hace 84 años es absolutamente vigente en los enfoques y teorías de la nueva salud pública y la salud colectiva.
Como salubrista su pensamiento y obra está marcada por la coherencia, consecuencia y lo innovador de sus planteamientos Esta manera de pensar la salud se fue forjando desde que era estudiante de medicina y hacía su práctica en el manicomio, ya en ese tiempo vinculaba la locura, el alcoholismo con las condiciones de vida miserable y también pobreza o lo insuficiente
de la atención médica.
E-COMMERCE PLATFORMS (MARKETPLACES): A LOOK INTO THE FUTURE
Authors: КАЗАНКИНА О.А. , КУБЛИН И.М. , ШУМАКОВА И.А. 
Published: April 2024

Электронная коммерция – одно из стремительно развивающихся направлений экономики страны. Она призвана обеспечивать посредством применения цифровых технологий наиболее гибкую, быструю и эффективную взаимосвязь производителей продукции, различных посредников и покупателей. Сегодня отечественные коммерческие структуры сталкиваются с проблемой поиска покупателей для реализации товаров различного назначения, используемых в повседневной жизни. В этой связи маркетплейсы стали новым этапом в развитии электронной коммерции как неотъемлемой части торговых отношений в розничной сети. Отметим, что маркетплейс представляет собой некоторую оптимизированную онлайн-платформу, на которой строится определенная бизнес-модель по предоставлению возможности приобретения товаров.
E-commerce is one of the most rapidly developing areas of Russia’s economy. The main goal of e-commerce is to establish swift, flexible, and efficient connection between manufacturers of products and potential intermediaries and consumers via the use of digital technologies. This is particularly relevant for domestic commercial businesses that have to search for potential customers through their own means. This paper explores how marketplaces have become a new stage in the development of e-commerce and an integral part of trade relations in the retail network.
THE TRANSFORMATION OF THE MODERN MODEL OF CORPORATE SOCIAL RESPONSIBILITY: TRENDS, FACTORS, AND RESULTS
Authors: КОЖУХОВА М.Т. 
Published: April 2024

В статье рассмотрены факторы, обуславливающие происходящую трансформацию модели корпоративной социальной ответственности в концепцию ESG. В результате проведенного анализа выделены современные тенденции развития корпоративной социальной ответственности. Отдельно приведены факторы, способствующие внедрению ESG-подхода в практику российских компаний и особенности реализации ESG-концепции в России. Для компаний игнорирующих «устойчивое развитие» выявлены возможные ESG-риски.
This paper considers the factors that determine the ongoing transformation of the corporate social responsibility model into the ESG concept. As a result of the analysis, the author highlights modern trends in the development of corporate social responsibility. The factors contributing to the introduction of the ESG approach into Russian companies and the specifics of the implementation of the ESG concept in Russia are presented separately. In addition, the paper identifies potential ESG risks for companies that ignore "sustainable development".