bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of aspirin therapy in cancer patients with thrombocytopenia and acute coronary syndromes
Authors: Sarkiss Mona G. , Yusuf S. Wamique , Warneke Carla L. , Botz Gregory , Lakkis Nasser , Hirch‐Ginsburg Cheryl , Champion J. Chris , Swafford Joseph , Shaw Andrew D. S. , Lenihan Daniel J. , Durand Jean‐Bernard 
Published: December 2006

AbstractBACKGROUND.Patients with cancer who have thrombocytopenia may experience acute coronary syndromes (ACS), and the use of aspirin (ASA) poses an increased risk of bleeding. The purpose of this study was to test the hypothesis that the benefit of ASA therapy in the treatment of ACS would extend to cancer patients with thrombocytopenia and outweigh the risks of severe bleeding.METHODS.The records of all cancer patients diagnosed with an ACS in 2001 and referred for cardiology consultation were reviewed. Patients were divided into 2 groups on the basis of platelet count, >100 cells k/μL and ≤100 cells k/μL. Data were collected on the use of ASA therapy, bleeding complications, and survival rates. The authors assessed group differences by using the Wilcoxon rank sum test or 2‐tailed Fisher exact test, as appropriate. Univariate and multivariate logistic regression models were used to assess factors potentially associated with 7‐day survival.RESULTS.In cancer patients with ACS and thrombocytopenia, those who did not receive ASA had a 7‐day survival rate of 6% compared with 90% in those who did receive ASA (P < .0001). There were no severe bleeding complications. Patients with a platelet count (>100 cells k/μL) who received ASA had a 7‐day survival rate of 88% compared with 45% in those who did not receive ASA (P = .0096).CONCLUSIONS.Therapy with ASA was associated with a significantly improved 7‐day survival after ACS in cancer patients, with or without thrombocytopenia, and not associated with more severe bleeding. Cancer 2007;109:621–627. © 2006 American Cancer Society.
Theoretical evaluation of spectral efficiency and outage probability of TDMA multihop cellular systems
Authors: Yamamoto Koji , Kusuda Atsushi , Nakano Tsuyoshi , Yoshida Susumu 
Published: December 2006

AbstractFor TDMA cellular systems that introduced multihop transmission, the spectral efficiency and outage probability in a single‐cell environment are formulated and evaluated numerically. By using approximations, the numerical evaluation is also conducted in an interference‐limited multicell environment and compared to simulation results. In formulating these performances, the focus is on the common points of multihop transmission and symbol rate control, and a method similar to the performance evaluation method of rate‐adaptive TDMA cellular systems is applied. In particular, the opposite effects of multihop transmission on the spectral efficiency are explicitly considered. In a single cell environment, instead of lowering the spectral efficiency somewhat by the introduction of multihop transmission, the cell coverage satisfying the allowable outage probability could be clearly expanded. A multicell environment could be implemented with cell reuses with a smaller allowable outage probability resulting from the introduction of multihop transmission. Consequently, an improved spectral efficiency is expected. © 2006 Wiley Periodicals, Inc. Electron Comm Jpn Pt 1, 90(4): 1–10, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecja.20366
ε‐separating nonlinear filter bank and its application to face image beautification
Authors: Arakawa Kaoru , Okada Takuya 
Published: December 2006

AbstractFor the purposes of separating the specific components of nonsteady signals, the ε‐separating nonlinear filter bank is proposed. Previously, the authors proposed a nonlinear digital filter called the ε‐filter. This filter effectively eliminates the small signal amplitude random noise superimposed on a signal with a large signal changing component. The ε‐filter bank proposed in this paper consists of these ε‐filters and separates the components by taking account of both the signal amplitude and frequency. Further, a filter system for beautifying facial images using this filter bank is proposed. The human facial image consists not only of large‐signal components such as the frame, eyes, nose, and mouth, but also of small‐signal high‐frequency components such as fine wrinkles as well as small‐signal medium‐frequency components such as large wrinkles and blemishes. Additionally, ultrasmall‐amplitude high‐frequency components expressing the natural roughness of the skin also exist. The present filter bank can eliminate wrinkles and blemishes while maintaining the natural roughness of the skin, allowing beautification of the skin of facial images to be performed effectively. © 2006 Wiley Periodicals, Inc. Electron Comm Jpn Pt 3, 90(4): 52– 62, 2007; Published online in Wiley InterScience (www.interscience. wiley.com). DOI 10.1002/ecjc.20241
Phase response of transfer functions and coherent field in a reverberation room
Authors: Takahashi Yoshinori , Tohyama Mikio , Yamasaki Yoshio 
Published: December 2006

AbstractThis paper analyzes the properties of sound field transfer functions that change with the sound source distance (SSD), by measuring reverberant room impulse responses from a point of view of the phase characteristics. We analyzed the propagation phase (PP) according to the SSD in a reverberant field that R. Lyon investigated, by using a narrow‐band linear regression analysis of the impulse responses and considered the relation to the zero distribution of the transfer function. As a result, we clarified that the SSD information is included in the phase frequency characteristics of the minimum‐phase component and the variances from the PP. The distance from the source where the PP could be observed corresponds to the coherent field based on the wave theory or the critical distance defined by the energy ratio of direct to reverberation sound. Therefore, the field where the PP could be observed in the minimum‐phase component of the transfer function can be treated as the direct sound field. In addition, we also present that the reverberation phase (RP) separated and extracted along with PP from the phase frequency characteristics is according to the estimated value from the number of non‐minimum‐phase zeros. © 2006 Wiley Periodicals, Inc. Electron Comm Jpn Pt 3, 90(4): 1–8, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecjc.20293
Recent advances in the control of morphology and surface chemistry of porous polymer‐based monolithic stationary phases and their application in CEC
Authors: Eeltink Sebastiaan , Svec Frantisek 
Published: December 2006

AbstractThis review focuses on developments in the field of polymer‐based monolithic columns for CEC published in the literature since the beginning of the year 2005. The possibility of in‐situ preparation as well as easy control over their porous properties and surface chemistries clearly make monolithic separation media an attractive alternative to capillary columns packed with particles. Different variables such as polymerization conditions, morphology, and surface chemistry are shown to directly affect performance of monolithic capillary columns in terms of efficiency, analysis time, and retention.
Neurogenic neuroepithelial and radial glial cells generated from six human embryonic stem cell lines in serum‐free suspension and adherent cultures
Authors: Nat Roxana , Nilbratt Mats , Narkilahti Susanna , Winblad Bengt , Hovatta Outi , Nordberg Agneta 
Published: December 2006

AbstractThe great potential of human embryonic stem (hES) cells offers the opportunity both for studying basic developmental processes in vitro as well as for drug screening, modeling diseases, or future cell therapy. Defining protocols for the generation of human neural progenies represents a most important prerequisite. Here, we have used six hES cell lines to evaluate defined conditions for neural differentiation in suspension and adherent culture systems. Our protocol does not require fetal serum, feeder cells, or retinoic acid at any step, to induce neural fate decisions in hES cells. We monitored neurogenesis in differentiating cultures using morphological (including on‐line follow up), immunocytochemical, and RT‐PCR assays. For each hES cell line, in suspension or adherent culture, the same longitudinal progression of neural differentiation occurs. We showed the dynamic transitions from hES cells to neuroepithelial (NE) cells, to radial glial (RG) cells, and to neurons. Thus, 7 days after neural induction the majority of cells were NE, expressing nestin, Sox1, and Pax6. During neural proliferation and differentiation, NE cells transformed in RG cells, which acquired vimentin, BLBP, GLAST, and GFAP, proliferated and formed radial scaffolds. γ‐Aminobutyric acid (GABA)‐positive and glutamate positive neurons, few oligodendrocyte progenitors and astrocytes were formed in our conditions and timing. Our system successfully generates human RG cells and could be an effective source for neuronal replacement, since RG cells predominantly generate neurons and provide them with support and guidance. © 2006 Wiley‐Liss, Inc.
The effects of rock fragments on hydrologic and hydraulic responses along a slope
Authors: Hung Kou‐Chan , Kosugi Ken'ichirou , Lee Tim Hau , Misuyama Takahisa 
Published: December 2006

AbstractA model describing the three‐dimensional matrix flow along a slope with rock fragments or impermeable blocks was developed. The model was combined with modified Picard's iteration to ensure mass conservation in the unsaturated flow. We found that rock fragments obstruct water flow along the slope. The groundwater table must be raised to provide a sufficient pore water pressure gradient to facilitate water flow, but higher pore water pressure may induce slope failure. We also conducted a bench‐scale laboratory flume experiment to examine the effects of impermeable blocks on downstream seepage flow. In addition, a numerical experiment was conducted to examine how different arrangements of impermeable blocks affect downstream seepage flow and pore water pressure. This research demonstrated that the hydraulic phenomena were affected when impermeable blocks were present, and pore water pressure increased as the position of impermeable blocks was lowered. Copyright © 2006 John Wiley & Sons, Ltd.
Modeling of degradation and drug release from a biodegradable stent coating
Authors: Prabhu Santosh , Hossainy Syed 
Published: December 2006

AbstractBiodegradable polymeric coatings on cardiovascular stents can be used for local delivery of therapeutic agents to diseased coronary arteries after stenting procedures. This can minimize the occurrence of clinically adverse events such as restenosis after stent implantation. A validated mathematical model can be a very important tool in the design and development of such coatings for drug delivery. The model should incorporate the important physicochemical processes responsible for the polymer degradation and drug release. Such a model can be used to study the effect of different coating parameters and configurations on the degradation and the release of the drug from the coating. In this paper, a simultaneous transport‐reaction model predicting the degradation and release of the drug Everolimus from a polylactic acid (PLA) based stent coating is presented. The model has been validated using in vitro testing data and was further used to evaluate the influence of various parameters such as partitioning coefficient of water, autocatalytic effect of the lactic acid and structural change of the matrix, on the PLA degradation and drug release. The model can be used as a tool for predicting drug delivery from other coating configurations designed using the same polymer‐drug combination. In addition, this modeling methodology has broader applications and can be used to develop mathematical models for predicting the degradation and drug release kinetics for other polymeric drug delivery systems. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2007
Key developmental regulators change during hyperoxia‐induced injury and recovery in adult mouse lung
Authors: Pogach Melanie S. , Cao Yuxia , Millien Guetchyn , Ramirez Maria I. , Williams Mary C. 
Published: December 2006

AbstractDevelopmentally important genes have recently been linked to tissue regeneration and epithelial cell repair in neonatal and adult animals in several organs, including liver, skin, prostate, and musculature. We hypothesized that developmentally important genes play roles in lung injury repair in adult mice. Although there is considerable information known about these processes, the specific molecular pathways that mediate injury and regulate tissue repair are not fully elucidated. Using a hyperoxic injury model to study these mechanisms of lung injury and tissue repair, we selected the following genes based upon their known or putative roles in lung development and organogenesis: TTF‐1, FGF9, FGF10, BMP4, PDGF‐A, VEGF, Ptc, Shh, Sca‐1, BCRP, CD45, and Cyclin‐D2. Our findings demonstrate that several developmentally important genes (Sca‐1, Shh, PDGF‐A, VEGF, BCRP, CD45, BMP4, and Cyclin‐D2) change during hyperoxic injury and normoxic recovery in mice, suggesting that adult lung may reactivate key developmental regulatory pathways for tissue repair. The mRNA for one gene (TTF‐1), unchanged during hyperoxia, was upregulated late in recovery phase. These novel findings provide the basis for testing the efficacy of post‐injury lung repair in animals genetically modified to inactivate or express individual molecules. J. Cell. Biochem. 100: 1415–1429, 2007. © 2006 Wiley‐Liss, Inc.
Role of Src‐family kinases in formation and trafficking of macropinosomes
Authors: Kasahara Kousuke , Nakayama Yuji , Sato Izumi , Ikeda Kikuko , Hoshino Masaki , Endo Takeshi , Yamaguchi Naoto 
Published: December 2006

AbstractSrc‐family kinases that localize to the cytoplasmic side of cellular membranes through lipid modification play a role in signaling events including membrane trafficking. Macropinocytosis is an endocytic process for solute uptake by large vesicles called macropinosomes. Although macropinosomes can be visualized following uptake of fluorescent macromolecules, little is known about the dynamics of macropinosomes in living cells. Here, we show that constitutive c‐Src expression generates macropinosomes in a kinase‐dependent manner. Live‐cell imaging of GFP‐tagged c‐Src (Src‐GFP) reveals that c‐Src associates with macropinosomes via its N‐terminus continuously from their generation at membrane ruffles, through their centripetal trafficking, to fusion with late endosomes and lysosomes. Fluorescence recovery after photobleaching (FRAP) of Src‐GFP shows that Src‐GFP is rapidly recruited to macropinosomal membranes from the plasma membrane and intracellular organelles through vesicle transport even in the presence of a protein synthesis inhibitor. Furthermore, using a HeLa cell line overexpressing inducible c‐Src, we show that following stimulation with epidermal growth factor (EGF), high levels of c‐Src kinase activity promote formation of macropinosomes associated with the lysosomal compartment. Unlike c‐Src, Lyn and Fyn, which are palmitoylated Src kinases, only minimally induce macropinosomes, although a Lyn mutant in which the palmitoylation site is mutated efficiently induces macropinocytosis. We conclude that kinase activity of nonpalmitoylated Src kinases including c‐Src may play an important role in the biogenesis and trafficking of macropinosomes. J. Cell. Physiol. 211: 220–232, 2007. © 2006 Wiley‐Liss, Inc.
Delay of acute intracellular pH recovery after acidosis decreases endothelial cell activation
Authors: Huck Volker , Niemeyer André , Goerge Tobias , Schnaeker Eva‐Maria , Ossig Rainer , Rogge Phillip , Schneider Matthias F. , Oberleithner Hans , Schneider Stefan W. 
Published: December 2006

AbstractReperfusion after ischemic conditions induces massive endothelial cell (EC) activation, an initial step of reperfusion injury. Reperfusion is characterized by reoxygenation, realkalinization and a localized increase of inflammatory stimuli. In this study, we focused on the influence of extracellular realkalinization on human umbilical vein endothelial cell (HUVEC) activation. We examined intracellular pH (pHin) and intracellular free calcium concentration ([Ca2+]in), a second messenger known to mediate von Willebrand factor (VWF) exocytosis in endothelium, upon realkalinization. Furthermore, we measured the agonist‐stimulated exocytosis of VWF, Interleukin‐8 and soluble P‐selectin (sP‐Selectin) as markers of EC activation. To verify a morphological correlate of EC activation, we finally observed platelet‐endothelial adherence during realkalinization using shear flow. Realkalinization of HUVEC was simulated by switching from bicarbonate buffered Ringer solution of an acidotic pHex of 6.4 to a physiologic pHex of 7.4. Extracellular realkalinization was accompanied by pHin recovery from 6.5 to 7.2 within 10 min. Application of cariporide, an inhibitor of the Na+/H+ exchanger subtype 1 (NHE), during extracellular realkalinization significantly delayed the early kinetics of intracellular realkalinization. Histamine stimulated [Ca2+]in was significantly increased upon realkalinization compared to control cells. Also agonist‐stimulated release of VWF, Interleukin‐8 and sP‐Selectin was massively enhanced during pHin recovery in comparison to control. Furthermore, we observed an increased platelet binding to endothelium. Interestingly, each of these realkalinization‐induced effects were significantly reduced by early application of cariporide. Therefore, delay of acute NHE‐dependent pHin recovery may represent a promising mechanism for inhibition of EC activation upon reperfusion. J. Cell. Physiol. 211: 399–409, 2007. © 2006 Wiley‐Liss, Inc.
Activation of the S phase DNA damage checkpoint by mitomycin C
Authors: Mladenov Emil , Tsaneva Irina , Anachkova Boyka 
Published: December 2006

AbstractWe have studied the rate of DNA synthesis, cell cycle distribution, formation of γ‐H2AX, and Rad51 nuclear foci and association of Rad51 with the nuclear matrix after treatment of HeLa cells with the interstrand crosslinking agent mitomycin C (MMC) in the presence of the kinase inhibitors caffeine and wortmannin. The results showed that MMC treatment arrested the cells in S‐phase and induced the appearance of γ‐H2AX and Rad51 nuclear foci, accompanied with a sequestering of Rad51 to the nuclear matrix. These effects were abrogated by caffeine, which inhibits the Ataxia‐telangiectasia mutated (ATM) and ATM‐ and Rad3‐related (ATR) kinases. However, wortmannin at a concentration that inhibits ATM, but not ATR did not affect cell cycle progression, damage‐induced phosphorylation of H2AX and Rad51 foci formation, and association with the nuclear matrix, suggesting that the S‐phase arrest induced by MMC is ATR‐dependent. These findings were confirmed by experiments with ATR‐deficient and AT cells. They indicate that the DNA damage ATR‐dependent S‐phase checkpoint pathway may regulate the spatiotemporal organization of the process of repair of interstrand crosslinks. J. Cell. Physiol. 211: 468–476, 2007. © 2006 Wiley‐Liss, Inc.
Development of radiolabeled peptides to target p185HER2/neu receptors of cancer
Authors: Su Zifen 
Published: December 2006

AbstractThe p185HER2/nue receptors which regulate the growth of cancer cells and are overexpressed in 20–30% of the cancers can be the markers for cancer diagnosis. This work describes the DTPA conjugation, Indium(III) complexes characterization, Tc‐99m labeling, and Biacore test of the peptides such as [Cys6‐Cys12]H‐GAGGYCDGFYACYMDV‐CONH2 (anti‐HER2/neu‐peptidomics, (Ala2)AHNP), [Cys6‐Cys12]H‐G(Abu)GGYCDGFYACYMDV‐CONH2 ((Abu2)AHNP), and H‐dYCALTYYDYECdFAY‐CONH2 (EP6, EGFR selective peptide) binding affinity to the p185HER2/neu proteins. The results show the evidence of EP6 binding to the immobilized p185HER2/neu proteins. The labeled EP6, [99mTc]DTPA‐EP6, had displayed greater association percentage to the lysate of T6‐17 cells expressing p185HER2/neu proteins compared to the labeled AHNPs. The uptake (in terms of ID%/g) of [99mTc]DTPA‐EP6 in animal xenografted tumor was seven folds greater than that of the [99mTc](Ala2)AHNP. The nature of the dual‐receptors (EGFR and HER2/neu) binding of EP6 is a merit for the peptide to target cancer. Copyright © 2006 John Wiley & Sons, Ltd.
Correlations between sea‐surface temperatures and warm season streamflow in northwest Mexico
Authors: Gochis David J. , Brito‐Castillo Luis , James Shuttleworth W. 
Published: December 2006

AbstractPrevious hydroclimatological analysis of the North American Monsoon (NAM) region of northwest México revealed significant sub‐regions of coherence in seasonal precipitation and streamflow. In this work, interannual variations in regionalized streamflow and rainfall‐runoff relationships are explored. Modulation of the monsoon hydroclimatology by large‐scale forcing mechanisms such as tropical, North Pacific, and Caribbean Sea‐surface temperature perturbations results in nonlinear responses in seasonal runoff that varies by region. Analyses reveal that the El Niño‐Southern Oscillation (ENSO) exerts a modest but statistically significant influence on NAM streamflow. Different sea‐surface temperature and sea‐level pressure indices exhibit markedly different lag‐correlation structures in different NAM streamflow regions and these relationships vary significantly according to the decadal scale sea‐surface temperature (SST) variability in the North Pacific. The structure of correlation patterns between eastern Pacific SST and regionalized NAM streamflow anomalies complicates the application of common ENSO indices as streamflow predictors. The occurrence of ENSO also has a significant impact on regional runoff fractions and on the partitioning of streamflow between the summer and winter seasons. The summer ENSO influence is explained, in part, by changes in the lower tropospheric pressure and wind fields, which result in modest increases in atmospheric moisture over the streamflow regions during La Niña episodes versus El Niño episodes. The results suggest that improved monitoring and prediction of ENSO variability, through careful development of eastern Pacific SST indices in the pre‐monsoon period should provide useful guidance for seasonal forecasts of regional monsoon streamflow. Copyright © 2006 Royal Meteorological Society
The importance of local‐scale openness within regions dominated by closed woodland
Authors: Fyfe Ralph 
Published: December 2006

AbstractNew and existing pollen data from Wales, UK, are used to assess the level of landscape openness at the regional and local scale. At the regional scale, the existing pollen data support the high‐forest model of vegetation structure by 6000 cal. yr. BC prior to any palynological signal for anthropogenic impact in the region. New data from two sites in southwest Wales follow the general regional pattern of early to middle Holocene vegetation succession, but are striking owing to maintenance of high non‐arboreal pollen percentages (NAPs) throughout the mid‐Holocene. It is argued that these NAPs indicate that a significant degree of openness can be found at the local level (and beyond the confines of the peat‐forming site) within regions characterised by closed woodland. It is possible that woodland development in these areas may have been suppressed by reduced drainage, although the role of grazing animals in maintenance of clearings cannot be assessed. Implications for this local degree of openness are discussed, in particular the significance of vegetation heterogeneity at the local scale for the construction of place or locale for prehistoric communities. Copyright © 2006 John Wiley & Sons, Ltd.