bluuebunny/crossref_metadata_2025_split huggingface dataset:
Causal relationship between gut microbiota and prostate cancer contributes to the gut-prostate axis: insights from a Mendelian randomization study
Authors: Wang Li , Zheng Yong-bo , Yin Shan , Li Kun-peng , Wang Jia-hao , Bao Er-hao , Zhu Ping-yu 
Published: March 2024

Abstract
Background
Changes in gut microbiota abundance have been linked to prostate cancer development. However, the causality of the gut-prostate axis remains unclear.

Methods
The genome-wide association study (GWAS) data for gut microbiota sourced from MiBioGen (n = 14,306), alongside prostate cancer summary data from PRACTICAL (n = 140,254) and FinnGen Consortium (n = 133,164). Inverse-variance-weighted (IVW) was mainly used to compute odds ratios (OR) and 95% confidence intervals (Cl), after diligently scrutinizing potential sources of heterogeneity and horizontal pleiotropy via the rigorous utilization of Cochran's Q test, the MR-PRESSO method, and MR-Egger. We used meta-analysis methods in random effects to combine the Mendelian randomization (MR) estimates from the two sources.

Results
The pooled analyses of MR results show that genus Eubacterium fissicatena (OR = 1.07, 95% CI 1.01 to 1.13, P = 0.011) and genus Odoribacter (OR = 1.14, 95% CI 1.01 to 1.27, P = 0.025) were positively associated with prostate cancer. However, genus Adlercreutzia (OR = 0.89, 95% CI 0.83 to 0.96, P = 0.002), Roseburia (OR = 0.90, 95% CI 0.83 to 0.99, P = 0.03), Holdemania (OR = 0.92, 95% CI 0.86 to 0.97, P = 0.005), Flavonifractor (OR = 0.85, 95% CI 0.74 to 0.98, P = 0.024) and Allisonella (OR = 0.93, 95% CI 0.89 to 0.98, P = 0.011) seems to be a protective factor for prostate cancer. Sensitivity analysis found no significant heterogeneity, horizontal pleiotropy, or reverse causal links in all causal associations.

Conclusion
This MR study lends support to a causal relationship between genetically predicted gut microbiota and prostate cancer. Research on the gut-prostate axis, along with further multi-omics analyses, holds significant implications for the prevention and treatment of prostate cancer.
Fabrication of phosphorus-doped graphitic carbonitride towards the photodegradation of ciprofloxacin and sulfamethoxazole
Authors: Tsolele R. , Arotiba O. A. , Malinga S. P. 
Published: March 2024

AbstractHerein, we present the application of a phosphorus-doped graphitic carbon nitride (P-g-C3N4) for the photodegradation of ciprofloxacin and sulfamethoxazole in water. The photocatalyst was prepared from doping g-C3N4 with phosphorus using different compositions of phosphoric acid (2%, 4%, and 6% w/v). The resultant photocatalysts (2%P-g-C3N4, 4%P-g-C3N4, and 6%P-g-C3N4) were characterized using Fourier transform infrared (FTIR), X-ray diffraction spectroscopy (XRD), scanning electron microscopy–energy-dispersive X-ray (SEM–EDX), and ultraviolet–visible diffuse reflectance mode spectrophotometry (UV–Vis DRS). Photocatalytic degradation studies of the targeted pollutants were performed and monitored using UV–Vis and liquid chromatography coupled with mass spectroscopy (LC–MS). The UV–Vis DRS showed a shift from 2.70 to 2.48 eV in the band gap after doping g-C3N4 with phosphorus. The degradation of sulfamethoxazole by P-g-C3N4 was found to be significantly higher (70%) as compared to g-C3N4 (50%). On the other hand, the removal of ciprofloxacin was found to be 60% for P-g-C3N4, while 50% was found to be the removal efficiency of g-C3N4. The high removal efficiencies were associated with the generated electron holes together with the hydroxyl radicals which played a predominant role in the successful degradation of ciprofloxacin and sulfamethoxazole. Recyclability studies showed that the photocatalyst obtained a high photocatalytic degradation of 65% toward sulfamethoxazole after five cycles. Degradation by-products such as anthralin acid (m/z 307) for ciprofloxacin and monohydroxylated I10 (m/z 269) for sulfamethoxazole were detected using LC–MS. Therefore, P-g-C3N4 serves as a promising photocatalyst for the effective remediation of wastewater generated by pharmaceutical industries.
Global planar dynamics with a star node and contracting nonlinearity
Authors: Alarcón Begoña , Castro Sofia B. S. D. , Labouriau Isabel S. 
Published: March 2024

AbstractThis is a complete study of the dynamics of polynomial planar vector fields whose linear part is a multiple of the identity and whose nonlinear part is a contracting homogeneous polynomial. The contracting nonlinearity provides the existence of an invariant circle and allows us to obtain a classification through a complete invariant for the dynamics, extending previous work by other authors that was mainly concerned with the existence and number of limit cycles. The general results are also applied to some classes of examples: definite nonlinearities, $${\textbf {Z}}_2\oplus {\textbf {Z}}_2$$

Z
2

⊕

Z
2

symmetric systems and nonlinearities of degree 3, for which we provide complete sets of phase-portraits.
Dual-Alloy Sand Mold Casting: Main Principles and Features
Authors: Lisova Liudmyla , Erber Maximilian , Rottenegger David , Fuchs Georg , Braunreuther Stefan , Volk Wolfram 
Published: March 2024

Abstract
The multi-material injector casting (MMIC) process allows the production of castings with two different alloys in a single process. The metal is introduced into the mold through a ceramic down sprue (injector) that moves with the rising surface of the melt. This results in a beneficial temperature distribution in the casting with enhanced filling and feeding properties. Combining two alloys in one casting affects the chemical composition, microstructure, and mechanical properties, which differ from those of the original alloys. The main goal of producing the dual-alloy castings is to adapt the alloy locally in the mixing zone according to the application needs. The original composition and characteristics of both alloys have to be ensured as much as possible. This article discusses the peculiarities of dual-alloy sand mold casting, considering the oxidation processes of the components under different conditions and the microstructure of the resulting ingots. The results of thermodynamic simulation, experimental dual-alloy sand mold casting, chemical composition, and macrostructure of the resulting castings are given in the article. The following factors have been investigated: the method of pouring two alloys (AlSi12 and AlSi9Cu3), which simulate two injector positions; the time between pouring each alloy (60, 90, and 120 s); the influence of a directional solidification with the bottom chill. The mixing zone was identified by the changes in the content of Cu measured by spark spectroscopy and EDS.
Pair correlations of logarithms of complex lattice points
Authors: Parkkonen Jouni , Paulin Frédéric 
Published: March 2024

AbstractWe study the correlations of pairs of complex logarithms of $${\mathbb {Z}}$$
Z
-lattice points in $${\mathbb {C}}$$
C
at various scalings, proving the existence of pair correlation functions. We prove that at the linear scaling, the pair correlations exhibit level repulsion, as it sometimes occurs in statistical physics. We prove total loss of mass phenomena at superlinear scalings, and Poissonian behaviour at sublinear scalings. The case of Euler weights has applications to the pair correlation of the lengths of common perpendicular geodesic arcs from the maximal Margulis cusp neighbourhood to itself in the Bianchi orbifold $${\text {PSL}}_2({\mathbb {Z}}[i]) \backslash {{{\mathbb {H}}}^3_{\mathbb {R}}}$$

PSL
2

(
Z

[
i
]

)

\

H

R
3

.
Production of glass ceramic from rice husk and periwinkle shells
Authors: Aremo B. , Isadare D. A. , Akinduro O. E. , Bello O. E. , Adeoye M. O. , Ayodeji S. A. , Abass G. F. , Oluwasegun K. M. 
Published: March 2024

AbstractGlass ceramic was produced by replacing the major glass forming materials, silica and calcium oxide, with derivates from rice husk and periwinkle shells respectively. Glass formulation comprising of silica extracted from the rice husk and calcium oxide from powdered calcined periwinkle shells were compounded with analytical grade sodium carbonate. Silica was extracted from rice husk and characterized using XRD. SEM/EDS of the periwinkle shell revealed a structure dominated by calcium and oxygen; however, there was a significant presence of magnesium. Glass ceramic was produced by melting the mixture at 1300 °C followed by melt quenching. FTIR of the material showed the presence of the carbonyl functional group, calcium oxide, magnesium oxide and various bond configurations of silica. SEM of the glass ceramic showed sparsely distributed particles of the crystalline phase, while XRD revealed the presence of 55% amorphous phase. Several crystalline phases were present, dominated by polymorphs of silica such as quartz (22.15 wt.%) and cristobalite (5.68 wt.%). Also present are mullite (5.58 wt.%), calcite (1.95 wt.%) and Wollastonite (6.86 wt.%). Noticeable in the crystalline phase is Whitlockite (2.33 wt.%), a magnesium and phosphorus rich animal-source bio ceramic, traceable to the periwinkle which may impart some bioactivity to the material.
Planktonic Marine Fungi: A Review
Authors: Peng Xuefeng , Amend Anthony S. , Baltar Federico , Blanco‐Bercial Leocadio , Breyer Eva , Burgaud Gaëtan , Cunliffe Michael , Edgcomb Virginia P. , Grossart Hans‐Peter , Mara Paraskevi , Masigol Hossein , Pang Ka‐Lai , Retter Alice , Roberts Cordelia , van Bleijswijk Judith , Walker Allison K. , Whitner Syrena 
Published: March 2024

AbstractFungi in marine ecosystems play crucial roles as saprotrophs, parasites, and pathogens. The definition of marine fungi has evolved over the past century. Currently, “marine fungi” are defined as any fungi recovered repeatedly from marine habitats that are able to grow and/or sporulate in marine environments, form symbiotic relationships with other marine organisms, adapt and evolve at the genetic level, or are active metabolically in marine environments. While there are a number of recent reviews synthesizing our knowledge derived from over a century of research on marine fungi, this review article focuses on the state of knowledge on planktonic marine fungi from the coastal and open ocean, defined as fungi that are in suspension or attached to particles, substrates or in association with hosts in the pelagic zone of the ocean, and their roles in remineralization of organic matter and major biogeochemical cycles. This review differs from previous ones by focusing on biogeochemical impacts of planktonic marine fungi and methodological considerations for investigating their diversity and ecological functions. Importantly, we point out gaps in our knowledge and the potential methodological biases that might have contributed to these gaps. Finally, we highlight recommendations that will facilitate future studies of marine fungi. This article first provides a brief overview of the diversity of planktonic marine fungi, followed by a discussion of the biogeochemical impacts of planktonic marine fungi, and a wide range of methods that can be used to study marine fungi.
Seismic Stratigraphy of Contourite Drift Deposits Associated With the Loop Current on the Eastern Campeche Bank, Gulf of Mexico
Authors: Lowery Christopher M. , Perez Cruz Ligia , Urrutia Fucugauchi Jaime , Wei Jingxuan , Austin James A. , Standring Patricia 
Published: March 2024

AbstractThe Loop Current is a key component of global circulation via the northward transport of warm, salty water, and an important influence on Gulf of Mexico hydrography. Understanding how the Loop Current will respond to ongoing anthropogenic warming is critically important, but the history of the Loop Current is poorly known. Here, we present the results of a high resolution (3–8 m) multichannel seismic survey of pelagic carbonate sediment drifts on the eastern Campeche Bank associated with the Loop Current. We identify three seismic megasequences: Megasequence A is a Lower Cretaceous carbonate platform, Megasequence B comprises Cretaceous to lower Cenozoic pelagic carbonates with weak/no contour current flow, and Megasequence C comprises a series of large (100s of m thick) contourite drifts representing the inception and history of the Loop Current. The base of the contourites is marked by a regionally mappable unconformity eroding underling strata, sometimes incising hundreds of meters. The drifts contain a succession of sequence sets separated from each other by regional unconformities and comprising plastered drifts and massive mounded drifts, which characterize modern deposition with active moats on the seafloor. A lack of sediment cores in the study area precludes age determination of these drifts, except for the youngest (Late Pleistocene). Comparison to legacy seismic lines across Deep Sea Drilling Project Site 95, outside our study area, implies that the base of Megasequence C is Oligocene in age, and that the Loop Current developed during the global reorganization of ocean circulation around the Eocene‐Oligocene Transition.
Long‐Term Variations of Energetic Electrons Scattered by Signals From the North West Cape Transmitter
Authors: Hu Jingle , Xiang Zheng , Ma Xin , Liu Yangxizi , Dong Junhu , Guo Deyu , Ni Binbin 
Published: March 2024

AbstractVery‐low‐frequency (VLF) signals emitted from ground‐based transmitters for submarine communication can penetrate the ionosphere and leak into the magnetosphere, leading to electron precipitation via wave‐particle interaction and thereby providing a potential means for radiation belt remediation. In this study, we systematically analyze the dependence of quasi‐trapped electron fluxes scattered by signals from the North West Cape (NWC) transmitter on electron energy, L‐shell, and geomagnetic activity (i.e., the Dst index) using long‐term measurements from the DEMETER satellite. Considering potentially changed theoretical cyclotron resonant condition, we find that the variations of wave normal angle (WNA) of NWC transmitter signals or of the background electron density can explain the variated “wisp” positions in energy versus L plane. The long‐term data analyzation suggests that the energy‐dependences increases can help to distinguish the different source mechanisms of quasi‐trapped electrons. The enhancement of quasi‐trapped electron fluxes induced by NWC transmitter signals is more obvious at L = 1.8 than L = 1.6 due to higher trapped flux levels and strong pitch angle diffusion induced by transmitter signals.
Diverse Structural Styles of the Northeastern Tethyan Himalaya in Southern Tibet Reveal the Early Collisional Tectonics of India and Asia
Authors: Tang Yu , Liang Xiao , Wang Genhou , Li Dian , Qing Zhanhui , Feng Yipeng , Zhang Wei , Han Ning , Tian Yang , Wang Zhuosheng 
Published: March 2024

AbstractThe poor understanding of the structural history of the Late Triassic flysch in the northeastern Tethyan Himalaya has caused many disputes regarding India‐Asia collisional tectonics. Here, we conducted an integrated study including tectonostratigraphic analysis, structural analysis, and zircon U‒Pb and muscovite 40Ar/39Ar dating to unravel the structural evolution of the Late Triassic flysch. Field geological mapping revealed that the flysch can be subdivided into three structural units, including the Gyaca mélange, Qiongjie‐Dengmu shear zone and Langjiexue fold‐thrust belt. The three units all contain voluminous siliciclastic rocks deposited in an abyssal submarine fan environment at the Indian passive continental margin. The Gyaca mélange shows a two‐stage deformation process that generated a collisional mélange resulting from the subduction of the Indian passive continental margin. 40Ar/39Ar dating of top‐to‐the‐south shear bands and block‐in‐matrix structure indicate that the India‐Asia collision happened no later than the Selandian (ca. 60 Ma). The divergent imbricated thrusting and folding of the Gyaca mélange and Langjiexue fold‐thrust belt formed a positive flower structure. The zircon U‒Pb and 40Ar/39Ar dating of syntectonic dikes and sericite flakes within the Gyaca mélange yield ages of ca. 56–55 Ma for the genesis of the divergent structures. Moreover, the Qiongjie‐Dengmu dextral shear zone yields a sericite 40Ar/39Ar age of ca. 35 Ma and thus indicates a transient strike‐slip stress regime. Generally, the early India‐Asia collision tectonics in the northeastern Tethyan Himalaya showed episodic evolution with changing structural styles from mélange formation to imbricate fold‐thrust belt development and finally strike‐slip shear generation.
Targeting metastasis-initiating cancer stem cells in gastric cancer with leukaemia inhibitory factor
Authors: Seeneevassen Lornella , Zaafour Anissa , Sifré Elodie , Genevois Coralie , Nguyen Tra Ly , Pobiedonoscew Yasmine , Giese Alban , Guignard Jérôme , Tiffon Camille , Rousseau Benoit , Raymond Anne-Aurélie , Belleannée Geneviève , Boeuf Hélène , Gronnier Caroline , Martin Océane C. B. , Giraud Julie , Lehours Philippe , Dubus Pierre , Varon Christine 
Published: March 2024

AbstractGastric cancer’s (GC) bad prognosis is usually associated with metastatic spread. Invasive cancer stem cells (CSC) are considered to be the seed of GC metastasis and not all CSCs are able to initiate metastasis. Targeting these aggressive metastasis-initiating CSC (MIC) is thus vital. Leukaemia inhibitory factor (LIF) is hereby used to target Hippo pathway oncogenic members, found to be induced in GC and associated with CSC features. LIF-treated GC cell lines, patient-derived xenograft (PDX) cells and/or CSC tumourspheres underwent transcriptomics, laser microdissection-associated proteomics, 2D and 3D invasion assays and in vivo xenograft in mice blood circulation. LIFR expression was analysed on tissue microarrays from GC patients and in silico from public databases. LIF-treated cells, especially CSC, presented decreased epithelial to mesenchymal transition (EMT) phenotype and invasion capacity in vitro, and lower metastasis initiation ability in vivo. These effects involved both the Hippo and Jak/Stat pathways. Finally, GC’s high LIFR expression was associated with better clinical outcomes in patients. LIF treatment could thus represent a targeted anti-CSC strategy to fight against metastatic GC, and LIFR detection in primary tumours could constitute a potential new prognosis marker in this disease.
Salinisation of drinking water ponds and groundwater in coastal Bangladesh linked to tropical cyclones
Authors: Tsai ChiSan , Hoque Mohammad A. , Vineis Paolo , Ahmed Kazi Matin , Butler Adrian P. 
Published: March 2024

AbstractSalinity is a widespread problem along the Asian coast, mainly in reclaimed lands where most people live. These low-lying areas are vulnerable to impacts from tropical cyclone induced storm surges. The role of such surges on the long-term salinity of water resources, particularly the salinisation of drinking water ponds, a key water resource, requires further investigation. Here we show, using high-resolution measurements of pond hydrology and numerical modelling, that episodic inundation events cause the widespread salinisation of surface water and groundwater bodies in coastal areas. Sudden salt fluxes in ponds cause salinity build-up in the underlying sediments and become a source of salinity. Rapid clean-up of drinking ponds immediately after a surge event can significantly minimize these salinity impacts, which are likely to increase under climate change. Our study has implications for coastal land use and water resources management in tropical deltas.
Treatment burden and regimen fatigue among patients with HIV and diabetes attending clinics of Tikur Anbessa specialized hospital
Authors: Muhammed Oumer Sada , Hassen Minimize , Taye Melaku , Beyene Eyob , Bedru Beshir , Tileku Melaku 
Published: March 2024

AbstractNascent studies showed that patients with chronic medical illnesses such as diabetes mellitus (DM) and HIV/AIDS are highly vulnerable to face both treatment burden and regimen fatigue. However, an attempt made so far in this sphere in sub-Saharan African health care context is dearth. Thus, this study aimed to determine the level of treatment burden and regimen fatigue of diabetic and HIV patients attending adult diabetic and ART clinics of TASH and explore patients’ and health care workers’ propositions to reduce treatment burden and regimen fatigue. An explanatory sequential mixed methods study was conducted at the adult HIV and DM clinics of TASH, Addis Ababa, Ethiopia from February 01-March 30, 2022. Simple random and purposive sampling techniques were employed to select participants for quantitative and qualitative studies, respectively. Descriptive analysis was done to summarize the quantitative data. Logistic and linear regression analyses were performed to identify predictors of treatment burden and regimen fatigue, respectively. P value < 0.05 was considered statistically significant. Qualitative data was analyzed by using a thematic analysis. A total of 300 patients (200 diabetes and 100 HIV) were included in the quantitative study. For the qualitative study, 14 patients and 10 health care workers (six nurses and four medical doctors) were included. Participants' mean global Treatment Burden Questionnaire (TBQ) and Treatment Regimen Fatigue Scale (TRFS) score were 28.86 ± 22.13 and − 42.82 ± 17.45, respectively. Roughly, 12% of patients experienced a high treatment burden. The presence of two or more comorbidities (adjusted odds ratio [AOR] = 7.95, 95% confidence interval [CI] 1.59–39.08), daily ingestion of more than five types of prescribed medications (AOR = 6.81, 95%CI 1.59–29.14), and good knowledge about DM and/or HIV (AOR = 0.33, 95%CI 0.12–0.92) were predictors of treatment burden. Poor availability of medications (β = 0.951, p < 0.001) was the only predictor of regimen fatigue. Patients and health care workers primarily proposed to foster self-care efficacy, advance administrative services of the clinic and hospital, and improve healthcare system provision. The findings of this study unveiled that a considerable proportion of patients experienced low levels of treatment burden and regimen fatigue. This study showed that boosting the patients’ self-care efficacy, upgrading administrative services of the clinic and hospital, and promoting the healthcare system provision had enormous significance in reducing treatment burden and regimen fatigue. Therefore, when designing patient-specific healthcare interventions for both HIV and diabetic patients’ various factors affecting both treatment burden and regimen fatigue should be considered to achieve the desired goals of therapy.
Motor imagery ability scores are related to cortical activation during gait imagery
Authors: Putzolu Martina , Samogin Jessica , Bonassi Gaia , Cosentino Carola , Mezzarobba Susanna , Botta Alessandro , Avanzino Laura , Mantini Dante , Vato Alessandro , Pelosin Elisa 
Published: March 2024

AbstractMotor imagery (MI) is the mental execution of actions without overt movements that depends on the ability to imagine. We explored whether this ability could be related to the cortical activity of the brain areas involved in the MI network. To this goal, brain activity was recorded using high-density electroencephalography in nineteen healthy adults while visually imagining walking on a straight path. We extracted Event-Related Desynchronizations (ERDs) in the θ, α, and β band, and we measured MI ability via (i) the Kinesthetic and Visual Imagery Questionnaire (KVIQ), (ii) the Vividness of Movement Imagery Questionnaire-2 (VMIQ), and (iii) the Imagery Ability (IA) score. We then used Pearson’s and Spearman’s coefficients to correlate MI ability scores and average ERD power (avgERD). Positive correlations were identified between VMIQ and avgERD of the middle cingulum in the β band and with avgERD of the left insula, right precentral area, and right middle occipital region in the θ band. Stronger activation of the MI network was related to better scores of MI ability evaluations, supporting the importance of testing MI ability during MI protocols. This result will help to understand MI mechanisms and develop personalized MI treatments for patients with neurological dysfunctions.