bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remifentanil for tracheal intubation without neuromuscular blocking drugs in adult patients: a systematic review and meta‐analysis
Authors: Santos L. , Zheng H. , Singhal S. , Wong M. 
Published: February 2024

SummaryThere is increasing interest in the use of short‐acting opioids such as remifentanil to facilitate tracheal intubation. The aim of this systematic review was to determine the efficacy and safety of remifentanil for tracheal intubation compared with neuromuscular blocking drugs in adult patients. We conducted a systematic search for randomised controlled trials evaluating remifentanil for tracheal intubation. Primary outcomes included tracheal intubation conditions and adverse events. Twenty‐one studies evaluating 1945 participants were included in the analysis. Use of remifentanil (1.5–4.0 μg.kg‐1) showed no evidence of a difference in tracheal intubation success rate compared with neuromuscular blocking drugs (risk ratio (95%CI) 0.97 (0.94–1.01); six studies; 1232 participants; I2 28%; p = 0.16; moderate‐certainty evidence). Compared with neuromuscular blocking drugs, the use of remifentanil (2.0–4.0 μg.kg‐1) makes little to no difference in terms of producing excellent tracheal intubation conditions (risk ratio (95%CI) 1.16 (0.72–1.87); two studies; 121 participants; I2 31%, p = 0.54; moderate‐certainty of evidence). There was no evidence of an effect between remifentanil (2.0–4.0 μg.kg‐1) and neuromuscular blocking drugs for bradycardia (risk ratio (95%CI) 0.44 (0.01–13.90); two studies; 997 participants; I2 81%; p = 0.64) and hypotension (risk ratio (95%CI) 1.05 (0.44–2.49); three studies; 1071 participants; I2 92%; p = 0.92). However, the evidence for these two outcomes was judged to be of very low‐certainty. We conclude that remifentanil may be used as an alternative drug for tracheal intubation in cases where neuromuscular blocking drugs are best avoided, but more studies are required to evaluate the haemodynamic adverse events of remifentanil at different doses.
Constructing a social responsibility system for professional sports clubs based on the perspective of China
Authors: Yang Xiannan , Lu Hongyu , Cai Junren , Zhang Shaojie 
Published: February 2024

AbstractThe development of CSR reflects the level and characteristics of professional sports organizations, and the CSR of professional sports clubs varies among different countries and regions. In order to explore the content of the CSR of Chinese professional sports clubs in a more comprehensive and systematic way, this study organizes previous studies on the CSR of clubs in different countries and regions, and analyzes the differences between Chinese professional sports clubs and clubs in Europe, North America, Japan, and other countries and regions. We collected the opinions of 20 experts through semi‐structured interviews and combined them with the “Five in One” overall layout to construct and explain the CSR system of professional sports clubs in China in the new era, filling the gaps in research on this topic. Research suggests that social economic responsibility, social political responsibility, social cultural responsibility, social construction responsibility, and social ecological responsibility constitute the CSR system of professional sports clubs in China. Within a certain range, the larger the scale and stronger the comprehensive strength of a club, the stronger its ability to fulfill its responsibilities, the more targets it fulfills, and the richer its content. The institutional environment and social awareness may account for this difference, and in a government‐led social environment or in the case of nationalized club ownership, the Chinese plan may be more applicable. Our research not only provides theoretical reference for subsequent research on the CSR content of professional sports clubs but also helps guide the CSR practice of clubs of different sizes, thereby promoting the exploration of diversified CSR development patterns of professional sports clubs in the academic community.
Seeing is more than believing: Personal experience increases climate action
Authors: Wei Xinni , Yu Feng , Peng Kaiping 
Published: February 2024

AbstractAlthough global warming is a serious problem that influences numerous people worldwide, individuals are still reluctant to change their behaviours. The present research investigates how local hot temperatures affect climate action in non‐Western groups. In Study 1, an analysis of temperature and information acquisition by Shanghai residents in 122 days found that heat increased attention and awareness of climate change. In Study 2 and Study 3, participants who were primed with heat‐related perceptions were more likely to take climate action in private and public spheres. In Study 4, we further identified that people who experienced hot temperature events increased their beliefs and efficacy about climate change, which in turn motivated them to take more climate action. Importantly, the mediating effects were significant both in the manipulation of heat and real‐world settings. Consistent with our theoretical perspective, seeing is more than believing because personal experience increases climate action by fostering climate change beliefs and efficacy.
Shame in social interaction: Descriptions of experiences of shame by participants with high or low levels of narcissistic traits
Authors: Koskinen Emmi , Henttonen Pentti , Kettunen Sanna Kie , Pesonen Sanna , Piispanen Matias , Voutilainen Liisa , Wuolio Mariel , Peräkylä Anssi 
Published: February 2024

AbstractIn this study, we investigate how personal experiences about shameful events are described in face‐to‐face social interaction, and how these stories differ between participants who have either high or low levels of narcissistic personality traits. The dataset consists of 22 dyadic conversations where the participants describe events where they felt ashamed of themselves. We found the narratives to vary in terms of five dimensions. With narcissistic individuals, the default narrative tended to exhibit a cluster of characteristics that gather at one end of these dimensions: (1) weak expressions of shame; (2) located in the story‐world; (3) low level of reflexivity as well as; (4) responsibility of the described event; and (5) a general level of description. We discuss the findings in relation to sociological and psychological theories of shame and suggest that individuals with narcissistic personality traits are more inclined to use suppressive conversational practices in their treatment of shame, thus providing a “window” to these interactional practices.
FoxO1 promotes ovarian cancer by increasing transcription and METTL14‐mediated m6A modification of SMC4
Authors: Tan Liping , Wang Shuangan , Huang Shijia , Tie Yujuan , Sai Na , Mao Yichen , Zhao Shuli , Hou Yayi , Dou Huan 
Published: February 2024

AbstractThe transcription factor forkhead box protein O1 (FoxO1) is closely related to the occurrence and development of ovarian cancer (OC), however its role and molecular mechanisms remain unclear. Herein, we found that FoxO1 was highly expressed in clinical samples of OC patients and was significantly correlated with poor prognosis. FoxO1 knockdown inhibited the proliferation of OC cells in vitro and in vivo. ChIP‐seq combined with GEPIA2 and Kaplan–Meier database analysis showed that structural maintenance of chromosome 4 (SMC4) is a downstream target of FoxO1, and FoxO1 promotes SMC4 transcription by binding to its −1400/−1390 bp promoter. The high expression of SMC4 significantly blocked the tumor inhibition effect of FoxO1 knockdown. Furtherly, FoxO1 increased SMC4 mRNA abundance by transcriptionally activating methyltransferase‐like 14 (METTL14) and increasing SMC4 m6A methylation on its coding sequence region. The Cancer Genome Atlas dataset analysis confirmed a significant positive correlation between FoxO1, SMC4, and METTL14 expression in OC. In summary, this study revealed the molecular mechanisms of FoxO1 regulating SMC4 and established a clinical link between the expression of FoxO1/METTL14/SMC4 in the occurrence of OC, thus providing a potential diagnostic target and therapeutic strategy.
Cinnamaldehyde protects cardiomyocytes from oxygen‐glucose deprivation/reoxygenation‐induced lipid peroxidation and DNA damage via activating the Nrf2 pathway
Authors: Li Yan‐guang , Li Jiang‐hong , Wang Hai‐qin , Liao Junhua , Du Xiao‐ya 
Published: February 2024

AbstractRapid restoration of perfusion in ischemic myocardium is the most direct and effective treatment for coronary heart disease but may cause myocardial ischemia/reperfusion injury (MIRI). Cinnamaldehyde (CA, C9H8O), a key component in the well‐known Chinese medicine cinnamomum cassia, has cardioprotective effects against MIRI. This study aimed to observe the therapeutic effect of CA on MIRI and to elucidate its potential mechanism. H9C2 rat cardiomyocytes were pretreated with CA solution at 0, 10, and 100 μM, respectively and subjected to oxygen‐glucose deprivation/reoxygenation (OGD/R). Then the cell viability, the NF‐κB and caspase3 gene levels, the reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio, superoxide dismutase (SOD) level, reactive oxygen species (ROS) generation, 4‐hydroxynonenal (4‐HNE), and malondialdehyde (MDA) were detected. The severity of DNA damage was assessed by tail moment (TM) values using alkaline comet assay. Besides, the DNA damage‐related proteins and the key proteins of the Nrf2 pathway were detected by western blot. CA treatment increased the cell viability, GHS/GSSG ratio, SOD level, PARP1, Nrf2, PPAR‐γ, and HO‐1 protein levels of H9C2 cardiomyocytes, while reducing NF‐κB, caspase3, ROS level, 4‐HNE and MDA content, γ‐H2AX protein level, and TM values. Inhibition of the Nrf2 pathway reversed the effect of CA on cell viability and apoptosis of OGD/R induced H9C2 cardiomyocytes. Besides, 100 μM CA was more effective than 10 μM CA. In the OGD/R‐induced H9C2 cardiomyocyte model, CA can protect cardiomyocytes from MIRI by attenuating lipid peroxidation and repairing DNA damage. The mechanism may be related to the activation of the Nrf2 pathway.
The role of information presentation for wildlife knowledge, attitude, and risk perception
Authors: Oehler Felicitas , Kimmig Sophia , Hagen Robert , Kimmerle Joachim , Cress Ulrike , Hackländer Klaus , Arnold Janosch , Flemming Danny , Brandt Miriam 
Published: February 2024

AbstractPublic opinion can have a decisive influence on conservation actions leading to a need to understand how public opinion is formed. In a survey with a representative sample of the German population, participants answered questions about foxes in two consecutive years. Different versions of a leaflet about foxes were distributed to 2448 participants before the second interview. We compared a narrative text presentation to a non‐narrative list of facts and examined the use of photographs and schematic graphs. We assessed how the presentation format and socio‐demographic factors affected the probability that participants read the leaflet. Using a before‐after/control‐impact design, we examined whether the leaflet affected people's fox‐related knowledge, attitude, and risk perception. The results show that participants were more likely to read the leaflet with increasing age and a higher educational level. Reading probability also increased with attitude toward foxes. Participants who read the leaflet completely gained more knowledge about foxes than those who read it only partly. Photographs also contributed to a higher knowledge gain, but schematic graphs did not. Moreover, participants who read a fact list gained more knowledge compared to the control condition. Furthermore, the combination of visual and textual features had an effect on attitude toward foxes. However, we found no evidence that any treatment affected risk perception. We discuss implications and derivations for science communication to improve conservation actions.
Tech‐infused classrooms: A comprehensive study on the interplay of mobile learning, ChatGPT and social media in academic attainment
Authors: Amjad Amjad Islam , Aslam Sarfraz , Tabassum Umaira 
Published: February 2024

AbstractMobile learning (M‐learning), ChatGPT and social media are integral to university education, improving accessibility, personalization and interactive engagement in the learning process. This paper aimed to investigate the role of M‐learning, ChatGPT and social media in university students' academic performance. It was a cross‐sectional quantitative investigation, and data were collected from 600 university students through a self‐developed questionnaire having four subscales (M‐learning, ChatGPT, social media and academic performance). Simple linear regression and process macro were deployed to test study hypotheses. The analysis revealed that M‐learning is a significant contributor to students' academic performance at the university level (β = .460, t(598) = 12.663, p < .001). Social media were found to be significantly mediating the relationship between M‐learning and academic performance with coefficient B = .267, SE = .038, t(597) = 7.08, p < .001, 95% CI [0.193, 0.341]. ChatGPT was significantly contributing to academic performance (B = .288, t(596) = 2.50, p = .013), but the interaction term had an insignificant effect on the relationship between M‐learning and academic performance (β = .292, t(596) = −0.43, p = .668). The study suggests that M‐learning can improve students' performance. The influence of social media and the non‐moderating role of ChatGPT indicate the need for strategic integration of these tools to enhance university students' outcomes. It is recommended that university students should judiciously use social media to enhance M‐learning. In contrast, universities should foster this integration to achieve educational aims and explore how AI tools like ChatGPT can be optimally deployed to improve learning.
Experiences from a cluster‐randomized trial (ParaNASPP) exploring triage and diagnostic accuracy in paramedic‐suspected stroke: a qualitative interview study
Authors: Guterud Mona , Hardeland Camilla , Bugge Helge Fagerheim , Sandset Else Charlotte , Svendsen Edel Jannecke , Hov Maren Ranhoff 
Published: February 2024

AbstractBackground and purposeTimely prehospital stroke recognition was explored in the Paramedic Norwegian Acute Stroke Prehospital Project (ParaNASPP) by implementation of stroke education for paramedics and use of the National Institutes of Health Stroke Scale (NIHSS) through a mobile application. The study tested triage and facilitated communication between paramedics and stroke physicians. To complement the quantitative results of the clinical trial, a qualitative approach was used to identify factors that influence triage decisions and diagnostic accuracy in prehospital stroke recognition experienced by paramedics and stroke physicians.MethodSemi‐structured qualitative individual interviews were performed following an interview guide. Informants were recruited from the enrolled paramedics and stroke physicians who participated in the ParaNASPP trial from Oslo University Hospital. Interviews were audio recorded, transcribed verbatim and approached inductively using the principles of thematic analysis.ResultsFourteen interviews were conducted, with seven paramedics and seven stroke physicians. Across both groups two overarching themes were identified related to triage decisions and diagnostic accuracy in prehospital stroke recognition: prehospital NIHSS reliably improves clinical assessment and communication quality; overtriage is widely accepted whilst undertriage is not.ConclusionParamedics and stroke physicians described how prehospital NIHSS improved communication quality and reliably improved prehospital clinical assessment. The qualitative results support a rationale of an application algorithm to decide which NIHSS items should prompt immediate prenotification rather than a complete NIHSS as default.
Increased leaf area index and efficiency drive enhanced production under elevated atmospheric [CO2] in a pine‐dominated stand showing no progressive nitrogen limitation
Authors: Palmroth S. , Kim D. , Maier C. A. , Medvigy D. , Walker A. P. , Oren R. 
Published: February 2024

AbstractEnhancement of net primary production (NPP) in forests as atmospheric [CO2] increases is likely limited by the availability of other growth resources. The Duke Free Air CO2 Enrichment (FACE) experiment was located on a moderate‐fertility site in the southeastern US, in a loblolly pine (Pinus taeda L.) plantation with broadleaved species growing mostly in mid‐canopy and understory. Duke FACE ran from 1994 to 2010 and combined elevated [CO2] (eCO2) with nitrogen (N) additions. We assessed the spatial and temporal variation of NPP response using a dataset that includes previously unpublished data from 6 years of the replicated CO2 × N experiment and extends to 2 years beyond the termination of enrichment. Averaged over time (1997–2010), NPP of pine and broadleaved species were 38% and 52% higher under eCO2 compared to ambient conditions. Furthermore, there was no evidence of a decline in enhancement over time in any plot regardless of its native site quality. The relation between spatial variation in the response and native site quality was suggested but inconclusive. Nitrogen amendments under eCO2, in turn, resulted in an additional 11% increase in pine NPP. For pine, the eCO2‐induced increase in NPP was similar above‐ and belowground and was driven by both increased leaf area index (L) and production efficiency (PE = NPP/L). For broadleaved species, coarse‐root biomass production was more than 200% higher under eCO2 and accounted for the entire production response, driven by increased PE. Notably, the fraction of annual NPP retained in total living biomass was higher under eCO2, reflecting a slight shift in allocation fraction to woody mass and a lower mortality rate. Our findings also imply that tree growth may not have been only N‐limited, but perhaps constrained by the availability of other nutrients. The observed sustained NPP enhancement, even without N‐additions, demonstrates no progressive N limitation.
Cliff‐edge forests: Xerothermic hotspots of local biodiversity and models for future climate change
Authors: Fragnière Yann , Champoud Luca , Küffer Nicolas , Braillard Luc , Jutzi Michael , Wohlgemuth Thomas , Kozlowski Gregor 
Published: February 2024

AbstractCliffs are remarkable environments that enable the existence of microclimates. These small, isolated sites, decoupled from the regional macroclimate, play a significant role in maintaining species biodiversity, particularly in topographically homogeneous landscapes. Our study investigated the microclimate of south‐exposed forests situated at the edge of sandstone cliffs in the western part of the North Alpine Foreland Basin in Switzerland and its role in local forest community composition. Using direct measurements from data loggers, as well as vegetation analyses, it was possible to quantify the microclimate of the cliff‐edge forests and compare it with that of the surrounding forests. Our results highlighted the significant xerothermic and more variable nature of the cliff‐edge forest microclimate, with a mean soil temperature up to 3.72°C warmer in the summer, higher annual (+28%) and daily (+250%) amplitudes of soil temperature, which frequently expose vegetation to extreme temperatures, and an 83% higher soil drying rate. These differences have a distinct influence on forest communities: cliff‐edge forests are significantly different from surrounding forests. The site particularities of cliff edges support the presence of locally rare species and forest types, particularly of Scots pine. Cliff edges must therefore be considered microrefugia with a high conservation value for both xerothermic species and flora adapted to more continental climates. Moreover, the microclimate of cliff‐edge forests could resemble the future climate in many ways. We argue that these small areas, which are already experiencing the future climate, can be seen as natural laboratories to better answer the following question: what will our forests look like in a few decades with accelerated climate change?
Long‐term nitrogen and phosphorus addition have stronger negative effects on microbial residual carbon in subsoils than topsoils in subtropical forests
Authors: Fan Linjie , Xue Yuewei , Wu Donghai , Xu Meichen , Li Andi , Zhang Baixin , Mo Jiangming , Zheng Mianhai 
Published: February 2024

AbstractHighly weathered lowland (sub)tropical forests are widely recognized as nitrogen (N)‐rich and phosphorus (P)‐poor, and the input of N and P affects soil carbon (C) cycling and storage in these ecosystems. Microbial residual C (MRC) plays a crucial role in regulating soil organic C (SOC) stability in forest soils. However, the effects of long‐term N and P addition on soil MRC across different soil layers remain unclear. This study conducted a 12‐year N and P addition experiment in two typical subtropical plantation forests dominated by Acacia auriculiformis and Eucalyptus urophylla trees, respectively. We measured plant C input (fine root biomass, fine root C, and litter C), microbial community structure, enzyme activity (C/N/P‐cycling enzymes), mineral properties, and MRC. Our results showed that continuous P addition reduced MRC in the subsoil (20–40 cm) of both plantations (A. auriculiformis: 28.44% and E. urophylla: 28.29%), whereas no significant changes occurred in the topsoil (0–20 cm). N addition decreased MRC in the subsoil of E. urophylla (25.44%), but had no significant effects on A. auriculiformis. Combined N and P addition reduced MRC (34.63%) in the subsoil of A. auriculiformis but not in that of E. urophylla. The factors regulating MRC varied across soil layers. In the topsoil (0–10 cm), plant C input (the relative contributions to the total variance was 20%, hereafter) and mineral protection (47.2%) were dominant factors. In the soil layer of 10–20 cm, both microbial characteristics (41.3%) and mineral protection (32.3%) had substantial effects, whereas the deeper layer (20–40 cm) was predominantly regulated by microbial characteristics (37.9%) and mineral protection (18.8%). Understanding differential drivers of MRC across soil depth, particularly in deeper soil layers, is crucial for accurately predicting the stability and storage of SOC and its responses to chronic N enrichment and/or increased P limitation in (sub)tropical forests.
Mode of SUV420H2 heterochromatin localization through multiple HP1 binding motifs in the heterochromatic targeting module
Authors: Nakao Masaru , Sato Yuko , Aizawa Arisa , Kimura Hiroshi 
Published: February 2024

AbstractConstitutive heterochromatin is transcriptionally repressed and densely packed chromatin, typically harboring histone H3 Lys9 trimethylation (H3K9me3) and heterochromatin protein 1 (HP1). SUV420H2, a histone H4 Lys20 methyltransferase, is recruited to heterochromatin by binding to HP1 through its Heterochromatic Targeting Module (HTM). Here, we have identified three HP1 binding motifs within the HTM. Both the full‐length HTM and its N‐terminal region (HTM‐N), which contains the first and second motifs, stabilized HP1 on heterochromatin. The intervening region between the first and second HP1 binding motifs in HTM‐N was also crucial for HP1 binding. In contrast, the C‐terminal region of HTM (HTM‐C), containing the third motif, destabilized HP1 on chromatin. An HTM V374D mutant, featuring a Val374 to Asp substitution in the second HP1 binding motif, localizes to heterochromatin without affecting HP1 stability. These data suggest that the second HP1 binding motif in the SUV420H2 HTM is critical for locking HP1 on H3K9me3‐enriched heterochromatin. HTM V374D, tagged with a fluorescent protein, can serve as a live‐cell probe to visualize HP1‐bound heterochromatin.