bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Cytotoxic Evaluation of Novel Dimethyl [1,1′‐Biphenyl]‐2,2′‐dicarboxylates Bearing 1,3,4‐Thiadiazole Moieties
Authors: Kong Xiang‐Wen , Zhang Yi‐Hua , Wang Tao , Lai Yi‐Sheng , Peng Si‐Xun 
Published: September 2008

AbstractIn search of novel anticancer agents, two series of dimethyl [1,1′‐biphenyl]‐2,2′‐dicarboxylate derivatives, 8a–8k and 9a–9k, containing both methylenedioxy and 1,3,4‐thiadiazole moieties were designed and synthesized. Cytotoxicity of these compounds was evaluated in vitro against five human tumor cell lines, i.e., HepG2, KB, A549, K562, and MCF‐7. The results indicated that 8h, 8j, 8k, 9d, 9g, 9h, 9j, and 9k showed notable anticancer activities comparable to or stronger than that of 5‐fluorouracil, a canonical anticancer drug. Structure–activity relationships were also discussed based on the experimental data obtained.
Pentacyclic Triterpenoids from the Aerial Parts of Lantana camara and Their Nematicidal Activity
Authors: Begum Sabira , Zehra Syeda Qamar , Siddiqui Bina Shaheen , Fayyaz Shahina , Ramzan Musarrat 
Published: September 2008

AbstractTwo new olean‐12‐ene triterpenoids, camarolic acid (1) and lantrigloylic acid (2), have been isolated from the aerial parts of Lantana camara, along with ten known triterpenes, namely, camaric acid, lantanolic acid, lantanilic acid, pomolic acid, camarinic acid, lantoic acid, camarin, lantacin, camarinin, and ursolic acid. The new compounds have been characterized as 3,25‐epoxy‐3α‐hydroxy‐22β‐{[(S)‐3‐hydroxy‐2‐methylidenebutanoyl]oxy}olean‐12‐en‐28‐oic acid (1) and 3,25‐epoxy‐3α‐hydroxy‐22β‐[(3‐methylbut‐2‐enoyl)oxy]olea‐9(11),12‐dien‐28‐oic acid (2) through spectroscopic studies and a chemical transformation. Seven of the constituents, namely pomolic acid, lantanolic acid, lantoic acid, camarin, lantacin, camarinin, and ursolic acid, were tested for nematicidal activity against root‐knot nematode Meloidogyne incognita. Pomolic acid, lantanolic acid, and lantoic acid showed 100% mortality at 1 mg/ml concentration after 24 h, while camarin, lantacin, camarinin, and ursolic acid exhibited 100% mortality at this concentration after 48 h. These results are comparable to those obtained with the conventional nematicide furadan (100% mortality at 1 mg/ml concentration after 24 h).
The Influence of the Nitrogen Substitution in Three Cytisine Derivatives as Ligands for the Neuronal nAChRs: A Structural and Theoretical Study
Authors: Bombieri Gabriella , Meneghetti Fiorella , Artali Roberto , Tasso Bruno , Canu Boido Caterina , Sparatore Fabio 
Published: September 2008

AbstractThree cytisine derivatives, (−)‐(7R,9S)‐1‐phenyl‐3‐(cytisin‐12‐yl)propan‐1‐one (1), (−)‐(7R,9S)‐1‐phenyl‐2‐(cytisin‐12‐yl)ethane (2), and (−)‐(7R,9S)‐1,2‐bis(cytisin‐12‐yl)ethane (3), with different electronic and steric features have been characterized by X‐ray analysis and theoretical calculations in order to evaluate how structural modulations affect the intrinsic binding affinity at the neuronal nicotinic receptors (nAChRs). The crystal structures of1and2, which display comparable affinities, are characterized by the same conformation of the cytisine moiety with different orientations of the substituent at N(2). In3, two independent molecules have the pyridinone rings diversely oriented. This compound has a lower affinity with respect to1and2, but it increases the expression of neuronal nAChRs. Compounds1, 2, and3retain the key prerequisite of the classical pharmacophoric models, with sp3‐N‐atomHBA distances close to the expected value, both in solid state and in solution (theoretical calculations), where, in contrast with the extended in the crystal state, acurled‐upconformation has been found, though maintaining theN‐substituent in equatorial position.
Poly(p‐phenylene ethynylene)s with Facially Amphiphilic Pendant Groups: Solvatochromism and Supramolecular Assemblies
Authors: Li Yan , Li Guangtao , Wang Xinyan , Lin Changxu , Zhang Yihe , Ju Yong 
Published: September 2008

AbstractNovel functionalized poly(p‐phenylene ethynylene)s (PPEs) bearing facially amphiphilic cholic and deoxycholic acid units are synthesized by a Pd‐catalyzed Sonogashira cross‐coupling reaction. Some interesting properties, particularly their optical and self‐assembly characteristics, are unraveled. The PPEs that carry bile acid substituents exhibit remarkable solvatochromism in a wide range of solvent systems, and judicious choice of the solvents can adjust the size and morphology of the formed nanoscale supramolecular aggregates. The incorporation of these naturally occurring building blocks can also impart biocompatibility to the conjugated system and stimulate the growth of living cells.
Gold‐Film‐Catalysed Hydrosilylation of Alkynes by Microwave‐Assisted, Continuous‐Flow Organic Synthesis (MACOS)
Authors: Shore Gjergji , Organ Michael G. 
Published: September 2008

AbstractThin gold films on the surface of glass capillaries have proven to be highly active catalysts for the rapid hydrosilylation of alkynes that are flowed through the reactor while being heated by microwave irradiation. The films are able to be reused at least five times with no loss of activity and with no detectable levels of gold showing up in the hydrosilylated products.
Molecular Structure, Theoretical Calculation and Thermal Behavior of DAG(NTO)
Authors: CHANG Chun‐Ran , XU Kang‐Zhen , HUANG Jie , LI Meng , SONG Ji‐Rong , MA Hai‐Xia , ZHAO Feng‐Qi 
Published: September 2008

AbstractA new compound, (NH2NH)2CNH2+C2N4O3H− [DAG(NTO)], was prepared by mixing the NaNTO·H2O aqueous solution and diaminogaunidine hydrochloride aqueous solution. Single crystals suitable for X‐ray measurement were obtained by recrystallization from water at room temperature. The crystal belongs to triclinic, space group P‐1 with crystal parameters of a=0.6732(3) nm, b=0.6745(3) nm, c=0.9840(4) nm, α=88.309(7)°, β=77.255(6)°, γ=86.520(7)°, V=4.349(3) nm3, Z=2, µ=0.144 mm−1, F(000) =228, and Dc=1.674 g/cm3. The theoretical investigation on DAG(NTO) as a structural unit was carried out by B3LYP, MP2 and HF methods with 6‐31+G(d) basis set. The apparent activation energy and pre‐exponential constant of the exothermic decomposition reaction of DAG(NTO) are 112.15 kJ·mol−1 and 109.603 s−1, respectively. The critical temperature of thermal explosion is 208.6 °C.
An Efficient Synthesis of Polysubstituted 1,3‐Enynes from (E)‐β‐Iodovinyl Sulfones and Terminal Alkynes
Authors: GU Xiao‐Xia , XIE Mei‐Hua , ZHAO Xin‐Yang , SUN Ying , ZHANG Wei , XIE Fa‐Dong , WANG Shao‐Wu 
Published: September 2008

AbstractSulfonyl‐substituted 1,3‐enynes were synthesized in moderate to high yields by Sonogashira coupling reaction of (E)‐β‐iodovinyl sulfones with terminal alkynes. The sulfonyl group was further transformed to various substitutents by desulfonylation coupling with Grignard reagents in the presence of NiCl2(PPh3)2.
Synthesis of 5‐Androstene‐3β,7α,17β‐triol and 5‐Androstene‐3β,7β,17β‐triol
Authors: LI He‐Ping , YU Peng , ZHANG Hong‐Jie , LIU Hong‐Min 
Published: September 2008

AbstractTwo important neuroactive steroids 5‐androstene‐3β,7α,17β‐triol (6) and 5‐androstene‐3β,7β,17β‐triol (7) were prepared through a microbial transformation of 5‐androstene‐3β,17β‐diol, which was the first report for the synthesis of compounds 6 and 7 through a microbial transformation with Mucor racemosu isolated by ourselves.
Molybdophosphoric Acid: An Efficient Keggin‐type Heteropoloacid Catalyst for the One‐pot Three‐Component Synthesis of 1‐Amidoalkyl‐2‐naphthols
Authors: JIANG Wen‐Qing , AN Li‐Tao , ZOU Jian‐Ping 
Published: September 2008

AbstractA one‐pot three‐component reaction of 2‐naphthol, aldehyde, urea or amide catalyzed by the molybdophosphoric acid (heteropolyacid) to afford 1‐amidoalkyl‐2‐naphthols is described, which is high yield with simple work‐up.
Magnetic HP‐β‐CD Composite Nanoparticle: Synthesis, Characterization and Application as a Carrier of Doxorubicin in vitro
Authors: ZHANG Hua , PENG Ming‐Li , CUI Ya‐Li , CHEN Chao 
Published: September 2008

AbstractHydroxylpropyl‐β‐cyclodextrin (HP‐β‐CD) was introduced to the surface of magnetic nanoparticles in the presence of NH3·H2O to synthesize magnetic HP‐β‐CD composite nanoparticles, which were used as a carrier in magnetic targeted drug delivery. The composite nanoparticles were characterized by FTIR, ICP‐AES, TEM and VSM. The results showed that the iron content in the composite nanoparticles was 55.4%. The range of size is 10–20 nm and the magnetization is 59.9 emu/g. The capacity of composite nanoparticles for doxorubicin adsorption is 87.8 µg/mg after incubation for 72 h. The cumulative percentage of released doxorubicin in PBS buffer (pH=7.4) in 1, 4, 10 d were 35.5%, 49.3% and 76.5%, respectively. Thus, the magnetic HP‐β‐CD composite nanoparticles could be a potential carrier in the magnetic targeted drug delivery.
Hydrolysis of Adiponitrile in Near‐critical Water
Authors: DUAN Pei‐Gao , NIU Yan‐Lei , WANG Yuan‐Yuan , DAI Li‐Yi 
Published: September 2008

AbstractHydrolysis of adiponitrile (ADN) in near‐critical water was successfully conducted in a batch reactor. Influences of m(AND)/m(water) ratio, temperature, time, m(AND)/m(additive) ratio, kind of additive and pressure on the yield of each product were investigated. Five compounds resulting from the hydrolysis of ADN, including 5‐cyanovaleramide, adipamide, adipamic acid, adipic acid and trace of 5‐cyanovaleric acid, were detected by high performance liquid chromatography. The results showed that change of ADN concentration and temperature had significant influences on the yields of adipamide, adipamic acid and adipic acid; time was the significant factor for the yield of 5‐cyanovaleric acid; and the yield of 5‐cyanovaleramide was more dependent on the ADN concentration.
Synthesis of Aromatase Inhibitors and Dual Aromatase Steroid Sulfatase Inhibitors by Linking an Arylsulfamate Motif to 4‐(4H‐1,2,4‐triazol‐4‐ylamino)benzonitrile: SAR, Crystal Structures, in vitro and in vivo Activities
Authors: Bubert Christian , Woo L. W. Lawrence , Sutcliffe Oliver B. , Mahon Mary F. , Chander Surinder K. , Purohit Atul , Reed Michael J. , Potter Barry V. L. 
Published: September 2008

Abstract4‐(((4‐Cyanophenyl)(4H‐1,2,4‐triazol‐4‐yl)amino)methyl)phenyl sulfamate (6 a) was the first dual aromatase–sulfatase inhibitor (DASI) reported. Several series of its derivatives with various linker systems between the steroid sulfatase (STS) and the aromatase inhibitory pharmacophores were synthesised and evaluated in JEG‐3 cells. The X‐ray crystal structures of the aromatase inhibitors, DASI precursors 42 d and 60, and DASI 43 h were determined. Nearly all derivatives show improved in vitro aromatase inhibition over 6 a but decreased STS inhibition. The best aromatase inhibitor is 42 e (IC50=0.26 nM) and the best DASI is 43 e (IC50 aromatase=0.45 nM, IC50 STS=1200 nM). SAR for aromatase inhibition shows that compounds containing an alkylene‐ and thioether‐based linker system are more potent than those that are ether‐, sulfone‐, or sulfonamide‐based, and that the length of the linker has a limited effect on aromatase inhibition beyond two methylene units. Compounds 43 d–f were studied in vivo (10 mg kg−1, single, p.o.). The most potent DASI is 43 e, which inhibited PMSG‐induced plasma estradiol levels by 92 % and liver STS activity by 98 % 3 h after dosing. These results further strengthen the concept of designing and developing DASIs for potential treatment of hormone‐related cancers.
Vitamin D receptor polymorphisms and the risk of cutaneous melanoma
Authors: Mocellin Simone , Nitti Donato 
Published: September 2008

AbstractIt has been hypothesized that polymorphisms in the vitamin D receptor (VDR) gene affect the risk of developing melanoma. However, results often are conflicting, and no meta‐analysis has been performed to date on published data. Six studies (cases, 2152; controls, 2410) that investigated the association between 5 VDR polymorphisms (TaqI, FokI, BsmI, EcoRV, and Cdx2) and the risk of melanoma were retrieved and analyzed. The model‐free approach was applied to meta‐analyze these molecular association studies. Available data suggested a significant association between the BsmI VDR polymorphism and melanoma risk (pooled odds ratio [OR], 1.30; 95% confidence interval [CI], 1.11‐1.53; P = .002; heterogeneity Cochran Q test, P > .1), and the population‐attributable risk was 9.2%. In contrast, the FokI polymorphism did not appear to be associated with such risk (OR, 1.09; 95% CI, 0.99‐1.21; P = .07; heterogeneity Cochran Q test, P > .1). For the TaqI and the EcoRV polymorphisms, significant between‐study heterogeneity did not support genotype data pooling. Only 1 study investigated the Cdx2 variant, and the findings were negative. Current evidence is in favor of an association between 1 VDR gene polymorphism (BsmI) and the risk of developing melanoma. The current findings prompt further investigation on this subject andindirectly support the hypothesis that sun exposure may have an antimelanoma effect through activation of the vitamin D system. Cancer 2008. © 2008 American Cancer Society.
Non‐locking tetrahedral finite element for surgical simulation
Authors: Joldes Grand Roman , Wittek Adam , Miller Karol 
Published: September 2008

AbstractTo obtain a very fast solution for finite element models used in surgical simulations, low‐order elements, such as the linear tetrahedron or the linear under‐integrated hexahedron, must be used. Automatic hexahedral mesh generation for complex geometries remains a challenging problem, and therefore tetrahedral or mixed meshes are often necessary. Unfortunately, the standard formulation of the linear tetrahedral element exhibits volumetric locking in case of almost incompressible materials. In this paper, we extend the average nodal pressure (ANP) tetrahedral element proposed by Bonet and Burton for a better handling of multiple material interfaces. The new formulation can handle multiple materials in a uniform way with better accuracy, while requiring only a small additional computation effort. We discuss some implementation issues and show how easy an existing Total Lagrangian Explicit Dynamics algorithm can be modified in order to support the new element formulation. The performance evaluation of the new element shows the clear improvement in reaction forces and displacements predictions compared with the ANP element in case of models consisting of multiple materials. Copyright © 2008 John Wiley & Sons, Ltd.
Cytomics and nanobioengineering
Authors: Pierzchalski Arkadiusz , Robitzki Andrea , Mittag Anja , Emmrich Frank , Sack Ulrich , O'Connor José‐Enrique , Bocsi József , Tárnok Attila 
Published: September 2008

AbstractThe finding that an individual's genome differs as much as by many million variants from that of the human reference assembly diminished the great enthusiasm that every disease could be predicted based on nucleotide polymorphisms. Even individual cells of an organ may be specifically equipped to perform specific tasks and that the information of individual cells in a cell system is key information to understand function or dysfunction. Therefore, cytomics received great attention during the last years as it allows to quantitatively and qualitatively analyzing great number of individual cells, cell constituents, and of their intracellular and functional interactions in a cellular system and also giving the concept of analysis of these data.Exhaustive data extraction from multiparametric assays and multiple tests are the prerequisite for prediction of drug toxicity. Cytomics, as novel approach for unsupervised data analysis give a chance to find the most predictive parameters, which describe best the toxicity of a chemical. Cytomics is intrinsically connected to drug development and drug discovery.Focused on small structures, nanobioengineering is the ideal partner of cytomics, the systems biological discipline for cell population analysis. Realizing the idea “from the molecule to the patient” develops and offers chemical compounds, proteins, and other biomolecules, cells as well as tissues as instruments and products for a wide variety of biotechnological and biomedical applications.The integrative nanobioengineering combining different disciplines of nanotechnology will promote the development of innovative therapies and diagnostic methods. It can improve the precision of the measurements with focus on single cell analysis. By nanobioengineering and whole body imaging techniques, cytomics covers the field from molecules through bacterial cells, eukaryotic tissues, and organs to small animal live analysis. Toxicological testing and medical drug development are currently strongly broadening. It harbors the promise to substantially impact on various fields of biomedicine, drug discovery, and predictive medicine.As the number of scientific data is rising exponentially, new data analysis tools and strategies like cytomics and nanobioengineering take a lead and get closer to application. Bionanoengineering may strongly support the quantitative data supply, thus strengthening the rational for cytomics approach. © 2008 Clinical Cytometry SocietyHow to cite this article: Pierzchalski A, Robitzki A, Mittag A, Emmrich F, Sack U, O'Connor J‐E, Bocsi J, Tárnok A. Cytomics and nanobioengineering. Cytometry Part B 2008; 72B: 416–426.
Symbol detection in spatial multiplexing system using particle swarm optimization meta‐heuristics
Authors: Khan Adnan Ahmed , Bashir Sajid , Naeem Muhammad , Shah Syed Ismail , Li Xiaodong 
Published: September 2008

AbstractSymbol detection in multi‐input multi‐output (MIMO) communication systems using different particle swarm optimization (PSO) algorithms is presented. This approach is particularly attractive as particle swarm intelligence is well suited for real‐time applications, where low complexity and fast convergence is of absolute importance. While an optimal maximum likelihood (ML) detection using an exhaustive search method is prohibitively complex, PSO‐assisted MIMO detection algorithms give near‐optimal bit error rate (BER) performance with a significant reduction in ML complexity. The simulation results show that the proposed detectors give an acceptable BER performance and computational complexity trade‐off in comparison with ML detection. These detection techniques show promising results for MIMO systems using high‐order modulation schemes and more transmitting antennas where conventional ML detector becomes computationally non‐practical to use. Hence, the proposed detectors are best suited for high‐speed multi‐antenna wireless communication systems. Copyright © 2008 John Wiley & Sons, Ltd.
Organizational effects of maternal testosterone on reproductive behavior of adult house sparrows
Authors: Partecke Jesko , Schwabl Hubert 
Published: September 2008

AbstractDespite the well‐known, long‐term, organizational actions of sex steroids on phenotypic differences between the sexes, studies of maternal steroids in the vertebrate egg have mainly focused on effects seen in early life. Long‐term organizational effects of yolk hormones on adult behavior and the underlying mechanisms that generate them have been largely ignored. Using an experiment in which hand‐reared house sparrows (Passer domesticus) from testosterone‐ or control‐treated eggs were kept under identical conditions, we show that testosterone treatment in the egg increased the frequency of aggressive, dominance, and sexual behavior of 1‐year‐old, reproductively competent house sparrows. We also show that circulating plasma levels of progesterone, testosterone, 5α‐dihydrotestosterone, and 17β‐estradiol did not differ between treatment groups. Thus, a simple change in adult gonadal hormone secretion is not the primary physiological cause of long‐term effects of maternal steroids on adult behavior. Rather, differences in adult behavior caused by exposure to yolk testosterone during embryonic development are likely generated by organizational modifications of brain function. Furthermore, our data provide evidence that hormone‐mediated maternal effects are an epigenetic mechanism causing intra‐sexual variation in adult behavioral phenotype. © 2008 Wiley Periodicals, Inc. Develop Neurobiol 2008
A novel role for anosmin‐1 in the adhesion and migration of oligodendrocyte precursors
Authors: Bribián Ana , Esteban Pedro F. , Clemente Diego , Soussi‐Yanicostas Nadia , Thomas Jean‐Léon , Zalc Bernard , de Castro Fernando 
Published: September 2008

AbstractAt embryonic stages of development, oligodendrocyte precursors (OPCs) generated in the preoptic area colonize the entire optic nerve (ON). Different factors controlling migration of ON OPCs have been identified, including secreted growth factors, morphogens and guidance cues, as well as cell adhesion molecules. We have shown previously that the soluble form of the extracellular matrix (ECM) protein anosmin‐1, impairs OPC migration induced by FGF‐2. In the present work, we show that anosmin‐1 is expressed by both migrating OPCs and axons of the retinal ganglion cells in the embryonic ON. In vitro, we observe that OPC migration is strongly impaired by contact with anosmin‐1 when used as a substrate and, in contrast to previous results, this effect is independent of FGF‐2/FGFR1 signaling. We also show that OPCs preferentially adhere to anosmin‐1 when compared with other ECM molecules used as substrates, and that when the endogenous anosmin‐1 expressed by OPCs is blocked, OPC adhesion to all the different substrates (including anosmin‐1), is significantly reduced. This novel effect of anosmin‐1 on cell adhesion is also independent of FGF‐2/FGFR1. We finally demonstrate that the blockade of the endogenous anosmin‐1 expressed by OPCs impairs their migration. Our data suggest that the endogenous anosmin‐1 expressed by OPCs is necessary for the correct adhesion of these cells to the different components of the ECM (including anosmin‐1 itself), contributing to the migration of these cells. © 2008 Wiley Periodicals, Inc. Develop Neurobiol 2008
Functional differentiation of a clone resembling embryonic cortical interneuron progenitors
Authors: Li Hedong , Han Yu R. , Bi Caixia , Davila Jonathan , Goff Loyal A. , Thompson Kevin , Swerdel Mavis , Camarillo Cynthia , Ricupero Christopher L. , Hart Ronald P. , Plummer Mark R. , Grumet Martin 
Published: September 2008

AbstractWe have generated clones (L2.3 and RG3.6) of neural progenitors with radial glial properties from rat E14.5 cortex that differentiate into astrocytes, neurons, and oligodendrocytes. Here, we describe a different clone (L2.2) that gives rise exclusively to neurons, but not to glia. Neuronal differentiation of L2.2 cells was inhibited by bone morphogenic protein 2 (BMP2) and enhanced by Sonic Hedgehog (SHH) similar to cortical interneuron progenitors. Compared with L2.3, differentiating L2.2 cells expressed significantly higher levels of mRNAs for glutamate decarboxylases (GADs), DLX transcription factors, calretinin, calbindin, neuropeptide Y (NPY), and somatostatin. Increased levels of DLX‐2, GADs, and calretinin proteins were confirmed upon differentiation. L2.2 cells differentiated into neurons that fired action potentials in vitro, and their electrophysiological differentiation was accelerated and more complete when cocultured with developing astroglial cells but not with conditioned medium from these cells. The combined results suggest that clone L2.2 resembles GABAergic interneuron progenitors in the developing forebrain. © 2008 Wiley Periodicals, Inc. Develop Neurobiol 2008