bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond
Authors: Mao Chao , Wang Min , Zhuang Li , Gan Boyi 
Published: February 2024

Abstract
Cell death resistance represents a hallmark of cancer. Recent studies have identified metabolic cell death as unique forms of regulated cell death resulting from an imbalance in the cellular metabolism. This review discusses the mechanisms of metabolic cell death—ferroptosis, cuproptosis, disulfidptosis, lysozincrosis, and alkaliptosis—and explores their potential in cancer therapy. Our review underscores the complexity of the metabolic cell death pathways and offers insights into innovative therapeutic avenues for cancer treatment.
Which Subjective Expectations Explain Asset Prices?
Authors: De la O Ricardo , Myers Sean 
Published: February 2024

Abstract
We present a method for determining whether errors in expectations explain asset pricing puzzles without imposing assumptions about the error mechanism. Using accounting identities and survey forecasts, we find that errors in expected long-term inflation explain price variation, return predictability, and the rejection of the expectations hypothesis for aggregate stock and bond markets. Errors in short-term (long-term) nominal earnings growth expectations explain (do not explain) stock price variation and return predictability. The relevant errors are consistent with mistakes about the persistence of forecasted variables and the response to surprises. A simple framework based on fundamental extrapolation successfully replicates these findings. (JEL G40, G12, G14, E71)
Driving effect of P16 methylation on telomerase reverse transcriptase-mediated immortalization and transformation of normal human fibroblasts
Authors: Zhang Xuehong , Li Paiyun , Gan Ying , Xiang Shengyan , Gu Liankun , Zhou Jing , Zhou Xiaorui , Wu Peihuang , Zhang Baozhen , Deng Dajun 
Published: February 2024

Abstract

Background:

P16 inactivation is frequently accompanied by telomerase reverse transcriptase (TERT) amplification in human cancer genomes. P16 inactivation by DNA methylation often occurs automatically during immortalization of normal cells by TERT. However, direct evidence remains to be obtained to support the causal effect of epigenetic changes, such as P16 methylation, on cancer development. This study aimed to provide experimental evidence that P16 methylation directly drives cancer development.

Methods:
A zinc finger protein-based P16-specific DNA methyltransferase (P16-Dnmt) vector containing a “Tet-On” switch was used to induce extensive methylation of P16 CpG islands in normal human fibroblast CCD-18Co cells. Battery assays were used to evaluate cell immortalization and transformation throughout their lifespan. Cell subcloning and DNA barcoding were used to track the diversity of cell evolution.

Results:
Leaking P16-Dnmt expression (without doxycycline-induction) could specifically inactivate P16 expression by DNA methylation. P16 methylation only promoted proliferation and prolonged lifespan but did not induce immortalization of CCD-18Co cells. Notably, cell immortalization, loss of contact inhibition, and anchorage-independent growth were always prevalent in P16-Dnmt&TERT cells, indicating cell transformation. In contrast, almost all TERT cells died in the replicative crisis. Only a few TERT cells recovered from the crisis, in which spontaneous P16 inactivation by DNA methylation occurred. Furthermore, the subclone formation capacity of P16-Dnmt&TERT cells was two-fold that of TERT cells. DNA barcoding analysis showed that the diversity of the P16-Dnmt&TERT cell population was much greater than that of the TERT cell population.

Conclusion:

P16 methylation drives TERT-mediated immortalization and transformation of normal human cells that may contribute to cancer development.
Novel Therapeutic Insights Into the Treatment of Pericarditis: Targeting the Innate Immune System
Authors: Vecchié Alessandra , Bonaventura Aldo , Golino Michele , Thomas Georgia , Abbate Antonio 
Published: February 2024

Abstract:
Acute pericarditis is characterized by pericardial inflammation that can be treated with anti-inflammatory drugs. A considerable percentage of patients develops recurrent pericarditis with several relapses. In developed countries, the idiopathic form is the most frequent and has a high risk of recurrences. Two pathophysiological mechanisms have been described for idiopathic recurrent pericarditis: autoimmune and autoinflammatory. The autoimmune mechanism is more frequently encountered in patients with rheumatologic disorders, especially systemic lupus erythematosus. The innate immune system plays a central role in the pathophysiology of pericarditis, especially in the autoinflammatory phenotype. Current evidence highlights the central role played by interleukin 1 and NLRP3 (NACHT, leucine-rich repeat, and pyrin domain-containing protein 3) in idiopathic recurrent pericarditis. Accordingly, interleukin 1 blockers have been approved for the treatment of this condition. Neutrophils are likely to be important in such setting; however, their role has only been partially investigated. In the present review, we have collected the current knowledge on the role of innate immune system in pericarditis pathophysiology and how this can be used to provide targeted treatments for patients with recurrent pericarditis.
Case Management in Prevention of 30-Day Readmission in Post-Coronary Artery Bypass Graft Surgery
Authors: Mary Annapoorna , Mzayek Fawaz , Lefler Leanne L. , Jiang Yu (Joyce) , Taylor Meghan Meadows 
Published: February 2024

Purpose of Study:
Thirty-day readmission is associated with increased morbidity and mortality among postoperative coronary artery bypass graft (CABG) surgery patients. Interventions such as case management and follow-up care may reduce 30-day readmission. The purpose of this article is to report a study on modifiable factors that may have significant implications for case management in the prevention of readmission after CABG surgery.

Primary Practice Setting(s):
The study population included all the adult patients who underwent first-time CABG surgery from January 1, 2013, to January 1, 2016, from a Mid-South hospital.

Methodology and Sample:
A retrospective case–control study was employed to examine 1,712 patients who underwent CABG surgery.

Results:
The results revealed that patients readmitted within 30 days had a significantly shorter length of stay (LOS) (6 days vs. 10 days; p < .0001), more days in intensive care unit (6 days vs. 4 days; p = .0391), and significantly higher diabetes/renal (4% vs. 1%), infection (17% vs. 2%), and respiratory-related diagnoses (10% vs. 1%; p < .0001).

Implications for Case Management Practice:
Among these factors, hospital LOS is a major factor that can be addressed through case management in addition to other modifiable risk factors. Understanding modifiable factors associated with higher readmission risk is crucial for effective intervention and case management planning.
An intelligent continuous bladder irrigation monitoring and control system: Development and preliminary assessment
Authors: Liu Chunxia , Wang Lu , Chen Zhiqian , Zhang Hongxian , Li Baohua 
Published: February 2024

Abstract

Objectives:
To design an intelligent continuous bladder irrigation monitoring and control system and preliminarily assess its sensitivity of the early warning of flushing anomalies.

Methods:
According to the principle of bladder irrigation, an intelligent continuous bladder irrigation monitoring and control system was designed. The Amesim fluid simulation software was used to establish a parameterized simulation model for the bladder perfusion process and simulate the dynamic changes of bladder pressure and volume under different perfusion speeds to assess the sensitivity of the early warning of flushing anomalies.

Results:
The intelligent system consisted of 3 parts: the monitoring part (a flushing fluid inlet flow monitoring device, a flushing fluid outlet flow monitoring device, and a flushing fluid outlet color recognition sensor), the transition part (a control motherboard), and the regulation part (an alarm device, an electric control device for flushing fluid input speed, and a squeezing device for flushing waste fluid line). The data of the parameterized simulation model for the bladder perfusion process suggested that the sensitivity of the system was acceptable.

Conclusion:
The intelligent bladder irrigation system can automatically detect, report, and resolve signal abnormalities, thereby achieving the closed-loop management of bladder irrigation. The intelligent system might be used in clinical settings to reduce the burdens of nurses and promote patients’ recovery.
A model for cortical activity sequences
Authors: Lehr Andrew B. , Erzmann Finn , Michaelis Carlo , Nowak Julia , Gail Alexander , Kumar Arvind , Tetzlaff Christian 
Published: February 2024

AbstractNetworks of neurons in the brain, that act on a timescale of milliseconds, can intrinsically generate reliable sequential activity on slow behavioral timescales of seconds. A possible mechanism for intrinsic sequence generation based on theoretical evidence points to distance-dependent connectivity with correlated spatial asymmetries, establishing an anisotropic network connectivity. We show that networks with such correlated asymmetric connectivity as well as symmetric distance-dependent connectivity match experimental data of connectivity motifs as well as neuronal activity statistics from rat and monkey cortex. At the network level, however, only the correlated asymmetric connectivity pattern generates spatiotemporal activity sequences on behaviorally relevant timescales, while the symmetric connectivity results in transient but stationary spatial bumps of neural activity. Our results strongly support the role of correlated asymmetries in connectivity for the generation of sequential activity in neural networks.
A parabrachial hub for the prioritization of survival behavior
Authors: Goldstein Nitsan , Maes Amadeus , Allen Heather N. , Nelson Tyler S. , Kruger Kayla A. , Kindel Morgan , Smith Nicholas K. , Carty Jamie R.E. , Villari Rachael E. , Cho Ella , Marble Erin L. , Khanna Rajesh , Taylor Bradley K. , Kennedy Ann , Betley J. Nicholas 
Published: February 2024

AbstractLong-term sustained pain in the absence of acute physical injury is a prominent feature of chronic pain conditions. While neurons responding to noxious stimuli have been identified, understanding the signals that persist without ongoing painful stimuli remains a challenge. Using an ethological approach based on the prioritization of adaptive survival behaviors, we determined that neuropeptide Y (NPY) signaling from multiple sources converges on parabrachial neurons expressing the NPY Y1 receptor to reduce sustained pain responses. Neural activity recordings and computational modeling demonstrate that activity in Y1R parabrachial neurons is elevated following injury, predicts functional coping behavior, and is inhibited by competing survival needs. Taken together, our findings suggest that parabrachial Y1 receptor-expressing neurons are a critical hub for endogenous analgesic pathways that suppress sustained pain states.
Executing marketing through a gender lens: a consumer purchase decision-making study in an emerging economy
Authors: Siraj Ahsan , Zhu Yongming , Taneja Shilpa , Ali Ehtisham , Guo Jiaxin , Chen Xihui 
Published: February 2024

PurposeWith rapidly changing marketing landscape, nowadays, the formulation of various marketing strategies is increasingly focused on how consumers tend to make decisions. To meet the highly demanding consumer expectations, market segmentation can be used as an important marketing strategy. Due to gender marketing concept familiarity in the contemporary world, gender difference is one of the reference features in the process of market segmentation for marketers. This research is aimed to examine various determining factors that foster consumer purchase decision-making and the differences between consumers of different genders while making shopping and purchase decisions with special reference to an emerging economy, i.e. Pakistan.Design/methodology/approachBased on a cross-sectional sample of 367 consumers, the study adapted Sproles and Kendall's (1986) Consumer Style Inventory (CSI) to scrutinize the decision-making of both genders in Pakistan. For data analysis, the exploratory and confirmatory factor analysis in addition to the structural equation modeling has been used.FindingsThe study emphasized that, with the exception of quality awareness, brand consciousness, fashion consciousness, option overload and price consciousness greatly affect buying decisions. In addition, when it comes to consumer purchase decision-making, significant gender variations were discovered for both fashion consciousness and price consciousness.Originality/valueDrawing upon the distinctive cultural characteristics of Pakistan and its people, in-depth research was conducted on purchasing behaviors of Pakistani consumers and the decision-making characteristics of customers of different genders were summarized. The outcomes are expected to make a significant contribution to the field of gender marketing by organizations.
A BIM-integrated multi objective optimization model for sustainable building construction management
Authors: N. Hemanth Kumar , Padala S.P. Sreenivas 
Published: February 2024

Purpose
The construction industry is tasked with creating sustainable, efficient and cost-effective buildings. This study aims to develop a building information modeling (BIM)-based multiobjective optimization (MOO) model integrating the nondominated sorting genetic algorithm III (NSGA-III) to enhance sustainability. The goal is to reduce embodied energy and cost in the design process.

Design/methodology/approach
Through a case study research method, this study uses BIM, NSGA-III and real-world data in five phases: literature review, identification of factors, BIM model development, MOO model creation and validation in the architecture, engineering and construction sectors.

Findings
The innovative BIM-based MOO model optimizes embodied energy and cost to achieve sustainable construction. A commercial building case study validation showed a reduction of 30% in embodied energy and 21% in cost. This study validates the model’s effectiveness in integrating sustainability goals, enhancing decision-making, collaboration, efficiency and providing superior assessment.

Practical implications
This model delivers a unified approach to sustainable design, cutting carbon footprint and strengthening the industry’s ability to attain sustainable solutions. It holds potential for broader application and future integration of social and economic factors.

Originality/value
The research presents a novel BIM-based MOO model, uniquely focusing on sustainable construction with embodied energy and cost considerations. This holistic and innovative framework extends existing methodologies applicable to various buildings and paves the way for additional research in this area.
An institutional perspective on the shifts in banking and capitalist ideology: sustainability, social and environmental insights
Authors: Saeudy Mohamed , Hussainey Khaled 
Published: February 2024

PurposeThis paper investigates the development of moralised business ideologies (MBIs) amongst sustainable banks as they navigate social and environmental business prospects.Design/methodology/approachEmpirical evidence is drawn from top-management-level interviews with 16 UK-based small and medium-sized banks that specialise in financing social and environmental projects.FindingsMBIs have emerged in the literature review and empirical data analysis as a new concept taken on by sustainable banks with roots closer to sustainability such as ethical practices, moralised values, sustainable business models and ecological standards. The results confirm that MBIs help banking institutions create a more sustained positive impact in terms of social and environmental business opportunities.Originality/valueThis paper offers novel evidence on the intersection between banking and MBIs, with a focus on social, sustainability and environmental considerations.
Ceremonial implementation at overseas locations: a multi-case study of a bilateral development agency
Authors: Fushimi Katsutoshi 
Published: February 2024

Purpose
Prior institutional duality research asserts that ceremonial implementation of organisational practice protects multinational corporations’ subsidiaries. However, the temporal dynamics of the safeguarding function has been under researched. Public sector organisations have also been ignored. This research aims to explore how the safeguarding function is created, maintained and disrupted using the overseas offices (OOs) of a bilateral development agency (BDA) as a case.

Design/methodology/approach
A multi-case study, underpinned by neo-institutionalism, was conducted. Data obtained from in-depth remote interviews with 39 informants from the BDA OOs were analysed using the “asking small and large questions” technique, four analytical techniques, cross-case synthesis and theoretical propositions.

Findings
A three-phase process was identified. The first phase is the appearance of discrepancies due to institutional duality. The second is the emergence of ceremonial implementation as a solution. In the third phase, “the creation, maintenance and disruption of a safeguarding function” begins. When ceremonial implementation successfully protects the OOs, the safeguarding function is created. The OOs are likely to repeat ceremonial implementation, thus sustaining the function. Meanwhile, when conditions such as management staff change, ceremonial implementation may not take place, and the safeguarding function disappears.

Research limitations/implications
The BDA OOs may not face strong host country regulative pressures because they are donors to aid-recipient countries. Hence, the findings may not directly apply to other public sector organisations.

Practical implications
Development cooperation practitioners should understand that ceremonial implementation is not exclusively harmful.

Originality/value
To the best of the author’s knowledge, this is the first institutional duality research that explores the temporal dynamics of safeguarding functions targeting public sector organisations.
Can online interactions help level the playing field for firms in different regions?
Authors: Chang Yuxuan , Zhao Xiaoyang 
Published: February 2024

PurposeThis paper examines whether technological changes that promote communications between investors and managers help bridge the gap in the cost of equity capital among firms in different regions.Design/methodology/approachWe use the online interaction platforms of listed firms in China and utilize brokerage presence (BP) to capture the geographic distribution of financial factors. We explore whether online interactions would reduce the cost of equity to a greater extent for firms located in low brokerage presence regions (hereafter “low-BP firms”) than those in high brokerage presence regions (hereafter “high-BP firms”).FindingsWe find low-BP firms benefit more from an improved information environment created by online interactions. We also find that posts about low-BP firms are more value-relevant and useful in processing corporate disclosures. Further, a higher number of interactions significantly enhances more informational efficiency for low-BP firms, and the effect of reducing the gap in financing costs is more pronounced when corporate information is complex.Originality/valueWe conclude that online interactions alleviate geography-induced information frictions and create a relatively level playing field for firms located in all regions.
Mastering digital leadership capabilities for business model innovation: the role of managerial decision-making and grants
Authors: Faiz Misbah , Sarwar Naukhez , Tariq Adeel , Memon Mumtaz Ali 
Published: February 2024

PurposeResearch has shown that business model innovation can facilitate most ventures to innovate and remain competitive, yet there has been limited work on how digital leadership capabilities influence business model innovation. Building on the dynamic capabilities view, we address this gap by linking digital leadership capabilities with business model innovation via managerial decision-making through provision of grants received by new ventures.Design/methodology/approachThe study is cross-sectional research. Data have been collected utilizing purposive sampling from 313 founding members of new ventures in high-velocity markets, i.e. from Pakistan. SPSS has been used to conduct the moderated mediation analysis.FindingsDigital leadership capabilities foster the business model innovation of the new ventures because they enable new ventures to capitalize on digital technologies and create new ways of generating value for the customers and themselves. Moreover, managerial decision-making mediates digital leadership capabilities and business model innovation relationship, whereas, grants moderate the indirect positive effect of digital leadership capabilities on business model innovation via managerial decision-making. The study generates initial evidence on the impact of digital leadership capabilities on business model innovation via managerial decision-making for new ventures. We advance knowledge on new ventures’ business model innovation by deep-diving into dynamic capabilities view and emphasizing digital leadership capabilities as a significant driver for business model innovation.Originality/valueWith the help of dynamic capabilities theory, this study analyzes how new ventures make use of digital leadership capabilities to promote business model innovation.
Mechanical properties and failure modes of additively-manufactured chiral metamaterials based on Euclidean tessellations: an experimental and finite element study
Authors: Mizzi Luke , Simonetti Arrigo , Spaggiari Andrea 
Published: February 2024

Purpose
The “chiralisation” of Euclidean polygonal tessellations is a novel, recent method which has been used to design new auxetic metamaterials with complex topologies and improved geometric versatility over traditional chiral honeycombs. This paper aims to design and manufacture chiral honeycombs representative of four distinct classes of 2D Euclidean tessellations with hexagonal rotational symmetry using fused-deposition additive manufacturing and experimentally analysed the mechanical properties and failure modes of these metamaterials.

Design/methodology/approach
Finite Element simulations were also used to study the high-strain compressive performance of these systems under both periodic boundary conditions and realistic, finite conditions. Experimental uniaxial compressive loading tests were applied to additively manufactured prototypes and digital image correlation was used to measure the Poisson’s ratio and analyse the deformation behaviour of these systems.

Findings
The results obtained demonstrate that these systems have the ability to exhibit a wide range of Poisson’s ratios (positive, quasi-zero and negative values) and stiffnesses as well as unusual failure modes characterised by a sequential layer-by-layer collapse of specific, non-adjacent ligaments. These findings provide useful insights on the mechanical properties and deformation behaviours of this new class of metamaterials and indicate that these chiral honeycombs could potentially possess anomalous characteristics which are not commonly found in traditional chiral metamaterials based on regular monohedral tilings.

Originality/value
To the best of the authors’ knowledge, the authors have analysed for the first time the high strain behaviour and failure modes of chiral metamaterials based on Euclidean multi-polygonal tessellations.