bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclotriphosphazene Ring as a Platform for Multiporphyrin Assemblies
Authors: Rao M. Rajeswara , Gayatri G. , Kumar Amit , Sastry G. Narahari , Ravikanth M. 
Published: February 2009

AbstractRings around a ring: The synthesis, characterization, material properties and biological studies of novel hexakis porphyrinato cyclotriphosphazene systems (see scheme) and their metal derivatives are described.magnified imageA simple method has been employed to synthesize a cyclotriphosphazene appended with six porphyrins. The reaction of one equivalent of hexachlorocyclotriphosphazene with six equivalents of 5‐(4‐hydroxyphenyl)‐10,15,20‐tri(p‐tolyl)porphyrin or ‐21‐thiaporphyrin in tetrahydrofuran in the presence of cesium carbonate, followed by simple column‐chromatography purification, afforded the hexaporphyrinato cyclotriphosphazene systems as the single products in 80–90 % yields. The metal(II) derivatives (CuII, ZnII) of the hexaporphyrinato cyclotriphosphazene systems were prepared by treating the hexaporphyrin assemblies with the appropriate metal salts under standard metallation conditions. The compounds are freely soluble in common organic solvents and were characterized by mass spectrometry, NMR, absorption, and fluorescence spectroscopy, and electrochemical techniques. Material studies carried out by using fluorescence microscopy, SEM, and AFM techniques showed that the hexaporphyrinato cyclotriphosphazene systems form ringlike architectures. Preliminary biological studies indicate that the hexacopper(II) porphyrin assembly can be used as an artificial nuclease.
The effects of varying lengths and powers of co2 laser pulses transmitted through an optical fiber on atherosclerotic plaques
Authors: Eldar M. , Battler A. , Gal D. , Rath S. , Rotstein Z. , Neufeld H. N. , Akselrod S. , Katzir A. , Gaton E. , Wolman M. 
Published: February 2009

AbstractWe have studied the changes induced in atherosclerotic arteries by a CO2 laser beam delivered through a silver halide optical fiber. We found that the crater depth and diameter correlate with the total energy delivered and with the mode of delivery. Short‐duration high‐power pulses caused shallower and narrower craters and less damage to the arterial wall compared to the same energy delivered as low‐power pulses of long duration. Thus, high‐power pulses for short periods may be an effective and safe procedure for evaporization of atherosclerotic plaques.
Familial Migraine and Coronary Artery spasm in two siblings
Authors: Fournier J. A. , Fernandez‐Cortacero J. A. P. , Granado C. , Gascóon D. 
Published: February 2009

AbstractA common pathophysiology for the clinical association of variant angina and migraine has been suggested, but the pathogenesis of both illnesses is yet unknown. Our report presents two siblings with both illnesses and a familial history of migraine where coronary artery spasm was documented, spontaneously in one and after the administration of ergonovine maleate in the other one. Our study strongly supports the hypothesis that genetic factors possibly play a role in the etiology of variant angina and migraine at least in some patients.
Urgent coronary artery bypass surgery in the presence of dressler's syndrome
Authors: Doble N. , Westaby S. , Goodwin J. F. 
Published: February 2009

AbstractThe clinical features of Dressler's syndrome which developed in a patient following a third myocardial infarction responded to a short course of prednisolone. However, angina at rest precipitated urgent coronary artery bypass surgery and pericardectomy.
Transient heart failure in an adult with kawasaki disease
Authors: Leclerc G. , Bégin P. , Laramée P. , Genest P. 
Published: February 2009

AbstractKawasaki disease is a mucocutaneous lymph node syndrome with important cardiovascular complications that usually afflicts young children. We describe a 31‐year‐old woman who developed transient heart failure during the acute phase of Kawasaki disease. The diagnosis was supported by the presence of all six criteria of the disease: fever, conjunctivitis, strawberry tongue, cervical lymphadenopathies, truncal exanthem, and periungual membranous desquamation. Related clinical and laboratory findings included heart failure, arthralgias, transverse nail grooves, thrombocytosis, and elevated serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), and bilirubin. Alternative diagnoses were excluded. During her acute febrile illness, the patient developed tachycardia, hypotension, pulmonary rales, S3 gallop, and hepatojugular reflux. The chest roentgenogram showed new Kerley A and B lines. A first‐pass isotopic ventriculography showed diffuse hypokinesia and decreased ventricular ejection fractions; spontaneous recovery occurred after a few days. A coronarography performed two months later showed no aneurysmal dilatation. Kawasaki disease is a cause, albeit rare, of myocardial dysfunction in the adult human, and should be sought for actively in a patient with heart failure during the course of an acute febrile illness, associated with mucocutaneous changes.
Effects of pindolol therapy on the size of experimentally induced myocardial infarction in the pig
Authors: Friedli H. P. , Althaus U. , Magnenat L. , Gurtner H. P. 
Published: February 2009

AbstractThe effect of pindolol on experimental myocardial infarction was studied in a pig model. Intravenous application of 0.05 mg pindolol per kg body weight was initiated one hour after coronary ligation and repeated at 12‐hour intervals for five days. No significant difference in infarct size could be found between pindolol‐treated animals (20.4±0.6% SEM of whole ventricular mass, n = 6) and untreated controls (20.5 ± 1.2% SEM, n=9). Hemodynamic data did not change significantly throughout the experiment. These results differ in part from those reported by other investigators: The disagreement may be due to the specific pharmacological properties of the applied drug, to variations in the dosages of beta blockers, as well as to differences in the study design.
Familial hypercholesterolemia and HLA antigens
Authors: Donadon V. , Antonini CANTERIN A. , De PAOLI P. , Borean M. , Villalta D. , Zanata G. , Santini G. F. 
Published: February 2009

AbstractHereditary factors play an important role in the etiology and progression of coronary heart disease (CHD), most probably by causing the appearance and the levels of its risk factors. To investigate if there is a correlation between familial hypercholesterolemia and HLA system antigens, 25 subjects of 7 families with familial hypercholesterolemia were compared with 14 normocholesterolemic related subjects. Compared to normocholesterolemic kindreds, the familial hypercholesterolemic subjects have a significant increased HLA‐Bw35 antigen and a lack of HLA‐A1. Therefore, the correlation found with some HLA system phenotypes improves our knowledge about familial hypercholesterolemia and aids in the identification of subjects affected with this disorder of lipid metabolism, which is one of the most important CHD risk factors.
Prediction of left ventricular function in acute anterior myocardial infarction by serum creatine kinase activity and precordial ECG mapping
Authors: Marchionni N. , Moschi G. , Lombardi A. , Tozzi P. , Salani B. , Di. BARI M. , Ferrucci L. , Paoletti M. 
Published: February 2009

AbstractRight cardiac catheterization, serial determination of creatine phosphokinase (CPK) and of CPK‐MB activities, and precordial 35‐lead ECG mapping were performed in 17 consecutive patients with a first anterior acute myocardial infarction (AMI) within 6 hours of the onset of symptoms. Left ventricular function as determined by the stroke index (SI, ml/m2) to mean pulmonary capillary wedge pressure (PCWP, mmHg) ratio inversely correlated either with the total CPK and CPK‐MB released and with peak enzymatic activity, or with the entity of early (6th hour ECG) ST‐segment elevation. Conversely, a direct correlation was found between the SI/PCWP ratio and the ratio of R to Q+S waves from late (48th hour) ECG. Residual left ventricular function after a first anterior AMI can therefore be estimated noninvasively in the individual patient by early precordial ECG mapping and by peak enzymatic activity.
The applicability of noninvasive his bundle electrogram to assessing the effect of digitalis on atrioventricular conduction
Authors: Otsuka K. , Otsuka K. , Nojima K. , Saito H. , Seto K. , Ozawa T. 
Published: February 2009

AbstractHis bundle electrograms were recorded by a signal averaging technique using the Takayasu vectorial lead system, and effects of ouabain on the atrioventricular conduction were investigated using Wistar rats. Ouabain was given intraperitoneally at 30 min intervals in doses of 1–40 mg/kg. When ouabain dosage was increased to 20 mg/kg, the prolongation of PQ interval became prominent and P waves were hidden on the preceding T waves. Dose‐related prolongation of PQ and AH intervals was observed in the 1–15 mg/kg dosages. Ouabain‐induced ventricular arrhythmias occurred in the 30 mg/kg dosage. Dose‐related prolongation of QRS duration and HV interval was observed in the 1–25 mg/kg dosages. These prolongations were significant by the analysis of variance (p<0.01). Prolongation of PQ and AH intervals is probably due to a digitalis‐induced increase in parasympathetic nerve activity. However, the reason for the prolongation of HV interval and QRS duration was uncertain. Direct effects of ouabain on the conduction system, or central nervous system effects of ouabain on cardiovascular function were speculated. These results suggest the applicability of the noninvasive record of His bundle electrogram to assessing the digitalis effect even on the human atrioventricular conduction.
Mechanical emergency recanalization of the left main coronary artery
Authors: Sigwart U. , Goy J.‐J. , Finci L. , Blanc M. , Grbic M. , Stumpe F. 
Published: February 2009

AbstractAcute occlusion of the left main coronary artery is normally fatal. According to the literature, only a few cases have been treated by intracoronary thrombolysis; the prolonged period of ischemia, however, resulted in severe left ventricular dysfunction and numerous complications. Therefore, effort should be directed to recanalize the left main coronary artery within the shortest possible interval. We followed this approach in a case of acute occlusion of a subtotal stenosis of the left main coronary artery which could be mechanically reopened and dilated within a few minutes. The intervention resulted in immediate reversal of profound cardiogenic shock and complete restoration of normal left ventricular function. At hospital discharge, the patient was asymptomatic with a negative bicycle stress test. Immediate mechanical recanalization and angioplasty appear to be a feasible approach in life‐threatening coronary occlusion.
Echocardiographic and hemodynamic features of severe aortic regurgitation with diastolic opening of the aortic valve
Authors: Martinez E. E. , Herman M. V. , Kay R. H. , Pontes S. C. , Brandao A. C. , Pfefferman A. , Arroyo J. B. , Portugal O. P. 
Published: February 2009

AbstractSevere aortic regurgitation may be associated with premature aortic valve opening. Several possible etiologies for this diastolic opening have been suggested. We present a patient with hemodynamic data, M‐mode and 2‐D echocardiography in the setting of severe aortic regurgitation and diastolic aortic valve opening. Our data lead us to conclude that aortic valve opening in this situation is neither from passive flotation nor dependent on atrial systole. We believe that active ventricular recoil mechanisms can facilitate increases in diastolic ventricular pressure which then can transiently exceed aortic pressure in the setting of severe aortic regurgitation. This hemodynamic observation suggests that the valve opening is an active process.
Application of a new spatial signal averaging device for the beat‐to‐beat detection of cardiac late potentials
Authors: Chen W‐C. , Zeng Z‐R. , Chow C. , Xine Q‐Z. , Kou L‐C. 
Published: February 2009

AbstractA new high resolution digital signal averaging device was developed to record precordial late potentials. The subjects examined included 8 normals (including medical patients with normal cardiovascular status), and 21 patients with coronary artery disease (CAD) and myocarditis of probable viral origin. Late potentials were evident in 11 cases (CAD 8 cases and myocarditis in 3 cases). In 10 patients, multiple ventricular premature beats and in 3 others, attacks of ventricular tachycardia had been present. Sudden cardiac death occurred later in one patient. It was concluded that late potentials as recorded by this simple new device are predictive of ventricular arrhythmias — sometimes life threatening. As no triggering is necessary, both conventional and beat‐to‐beat signal averaging can be carried out and the presence of various arrhythmias is negligible.
Assessment of myocardial function by calculation of two energetic parameters from pressure‐volume relations and wall thickness in human ventricles
Authors: Holubarsch C H. , Hasenfuss G. , Just H. 
Published: February 2009

AbstractFor defining myocardial performance in chronic cardiac diseases and during acute pharmacological interventions we created a new index of performance based on myocardial mechanical and energetic counterparts. From angiocardiographic pressure‐volume data the pressure‐volume integral is analyzed and divided by left ventricular muscle mass, yielding work done by a unit of myocardium (E1). From pressure‐volume data the stress‐time integral σ.t is evaluated by using an ellipsoidal calculation model. In order to compare E1 with the σ.t the σ.t is transformed into energetic units on the basis of new physiologic myothermal findings (E2). Then, the sum of E1 and E2 (i.e., the maximum of mechanical performance), and the ratio of E1 to the sum of E1 and E2 can be defined (i.e., the myocardial work related to the energy consumed during a contraction). By calculating E1 and E2, we are able to analyze the myocardial efficiency of work production. These parameters are proposed for judging the myocardial performance and efficiency in congestive heart failure and the effects of positive inotropic substances and vasodilators.
Acute thrombosis of a composite ascending aortic conduit containing a bjork‐shiley valve during pregnancy: successful emergency cesarean section and operative repair
Authors: Shemin R. J. , Phillippe M. , Dzau V. 
Published: February 2009

AbstractA 31‐year‐old female had an ascending aortic conduit with a Bjork‐Shiley valve placed for an aortic dissection. A year later she became pregnant and was placed on heparin instead of coumadin therapy. She then developed a distal aortic dissection and was hospitalized for close medical monitoring of fetal status and maturity. At 33 weeks of gestation the aortic valve thrombosed, resulting in pulmonary edema and cardiac arrest. Emergency cesarean section and replacement of the aortic valve and ascending aortic conduit was successful in salvaging mother and child. Both are well at 2 years followup. The case illustrates the hazards of prosthetic valves in pregnant patients and cardiac surgery during pregnancy. These issues are reviewed along with the details leading to successful surgical management.
Experimental study on the relationship between cardiac arrhythmias and sleep states by ambulatory ecg‐EEC monitoring
Authors: Otsuka K. , Ikari M. , Ichimaru Y. , Saito H. , Kawakami T. , Otsuka K. , Kaba H. , Seto K. 
Published: February 2009

AbstractThe relationship between cardiac arrhythmias and sleep states was investigated in rats using the ambulatory ECG‐EEG monitoring system under the 14/10 lightdark illumination schedule. Records of 14 rats obtained over 94 days were analyzed. Bradyarrhythmias (SA block and AV block) and ventricular arrhythmias [ventricular premature contraction (VPC) and short run of VPCs (ventricular tachycardia, VT)] were observed. Average number of episodes of bradyarrhythmia per day was 7.5, and the ratio of SA block to AV block was 34.9% to 65.1%. Average VPC or VT occurrence per day was 0.9 or 0.1 times, respectively. Sleep states were divided into alertness, slow‐wave sleep, and paradoxical sleep, and the relationship between sleep states and arrhythmias was investigated. Bradyarrhythmias appeared predominantly during paradoxical sleep, while ventricular arrhythmias appeared during alertness as well as paradoxical sleep. Bradyar‐rhythmic episodes decreased by right or left vagotomy 78% or 70%, respectively. Sinus bradyarrhythmias disappeared almost completely by the right vagotomy, while the occurrence of AV block decreased by the right or left vagotomy. Circadian rhythms in arrhythmias were also analyzed by the cosine‐fitting technique, and significant circadian rhythms were demonstrated in both bradyarrhythmias and ventricular arrhythmias. Acrophases were 9:56 A.M. and 1:47 A.M., respectively. Occurrence of VT was rare, but the most frequent incidental time zone was immediately following transition from light effects (rest) to dark (activity). This knowledge of circadian rhythm effects in arrhythmias must be incorporated into improved treatment of arrhythmias.
24‐Hour blood pressure differences in hypertension and normotension in bed‐confined subjects
Authors: Stamatelopoulos S. , Petrou P. , Papamichael C. , Mouskos C. , Sideris D. , Moulopoulos S. 
Published: February 2009

AbstractThis study investigates whether the degree of hypertension may be evaluated by information derived from the 24‐h blood pressure (BP) curve unrelated to the pressure height. We performed 24‐h BP intra‐arterial monitoring in 52 bed‐confined subjects (10 normotensives, 10 borderlines, and 32 hypertensives on WHO criteria). Computer analysis of 1152 BP values per subject per 24‐h revealed the following: (1) During the night hours, the percentage of the 1152 systolic BP values ≥160 (in mmHg) increased (or did not change if 100%) in all subjects with mean 24‐h systolic BP (24‐h BP) > 170 and it decreased (or did not change if 0%) in all subjects with 24‐h BP <150. The change in the percentage of the 1152 diastolic BP values≥95 during the night hours did not correlate to either the mean 24‐h diastolic or systolic BP. (2) The higher the mean 24‐h systolic BP, the lower the skewness of the distribution of the 1152 systolic BP values (p<0.01). No such correlation existed between the skewness of the distribution of the 1152 diastolic BP values and either the mean 24‐h diastolic or systolic BP. It is concluded that both the change in systolic BP during the night hours and the skewness of its distribution during the 24‐h monitoring period are correlated to the severity of hypertension.
Recovery of ventricular late potentials from body surface using the signal averaging and high resolution ecg techniques
Authors: Hombach V. , Höpp H. W. , Kebbel U. , Trei Osterspey I. S. A. , Eggeling T. , Winter U. , Hirche H. , Hilger H. H. 
Published: February 2009

AbstractIn 70 patients (3 females and 67 males), aged 16–72 years (mean: 51±9 years), the low noise ECG was recorded from body surface by the signal averaging and the high resolution beat‐to‐beat techniques. We found 61 patients were suffering from coronary heart disease, 4 had atypical coronary heart disease (syndrome X), 4 had dilatative cardiomyopathy, and one had the long QT syndrome (Romano‐Ward syndrome). We found the following recovery rates for ventricular late potentials within the ST segment with the averaging technique: clearcut in 13/53 patients, doubtful in 16/53 patients, and late potentials absent in 26/53 patients. With the beat‐to‐beat technique the following recovery rates were found: clearcut late potentials in 27/70 patients, doubtful in 23/70 patients, none in 20/70 patients, and intermittently occurring late potentials in 18/70 patients (categorized as doubtful late potentials). When comparing the detection of late potentials with both methods in individual patients, we found concordant results in 39/53 patients studied (positive with both methods in 24/53 patients, negative with both methods in 15/53 patients), and discordant results in 14/53 patients (positive with the beat‐to‐beat technique and negative with the averaging technique in 12 individuals, negative with the beat‐to‐beat technique and positive with the averaging technique in the remaining 2 patients). The correlation between the incidence of late potentials and the presence of exercise‐induced myocardial ischemia (submaximal bicycle exercise) was higher when using the high resolution beat‐to‐beat technique, as holds also true for the correlation to complex ventricular arrhythmias. Dynamic changes of late potentials were only detectable by the beat‐to‐beat technique, which seems to be a considerable advantage over the averaging technique. In the clinical setting, both methods for retrieval of ventricular late potentials should be applied in order to increase the information and to provide the facilities of investigating larger patient populations for screening purposes.
Pirmenol in termination of paroxysmal supraventricular tachycardia
Authors: Toivonen L. K. 
Published: February 2009

AbstractAn assessment was made of the effect of pirmenol in the termination of paroxysmal supraventricular tachycardia (SVT). Sinus rhythm was restored by intravenous administration in 11 of 17 patients during a spontaneous attack. Another 8 patients were studied electrophysiologically. Pirmenol terminated an induced SVT in 3 of 5 patients having an atrioventricular (AV) intranodal re‐entry mechanism but in none of 3 patients having an atrioventricular bypass tract as one re‐entrant limb. The overall success in restoring sinus rhythm was 14 of 25 patients (56%). The drug was hemodynamically well tolerated even in cases of continued SVT. Pirmenol increased the atrial effective refractory period and had no obvious effect on AH and HV intervals. The functional refractory period of the AV node was decreased, probably by an anticholinergic effect. The effective and functional refractory periods of retrograde atrioventricular conduction via the AV node and bypass tract were increased in some patients. The mechanism terminating the AV intranodal SVT was a block in the retrograde part of the dual AV nodal pathway, a typical antiarrhythmic Class I effect.
Left predominant coronary circulation in patients with valvular aortic stenoses
Authors: Kober G. , Klepzig H. , Kaltenbach M. 
Published: February 2009

AbstractThis study was conducted to examine whether a correlation exists between the incidence of aortic stenosis and predominant left coronary perfusion. Therefore, coronary angiograms of 77 patients with mitral stenosis (Group 1), 50 patients with combined mitral valve disease and pure mitral insufficiency (Group 2), 61 patients with aortic insufficiency with or without mitral valve disease (Group 3), 49 patients with pure aortic stenosis (Group 4), and 69 patients with combined aortic valve disease and aortic stenosis with concomitant mitral valve disease (Group 5) were reviewed. Group 6 consisted of 20 patients with coronary heart disease. A statistically significant accumulation of left coronary circulation was found in patients with pure aortic stenosis (Group 4) (33%) as well as in patients with combined aortic valve disease (19%). The frequency of predominant left coronary circulation was comparable in all other patients (Group 1: 8%; Group 2: 10%; Group 3: 8%; Group 6: 7.5%). Thus, the presence of left predominance in a diagnostic coronary arteriogram performed in a patient with aortic stenosis could be a clue that the aortic stenosis is congenital.