bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical usefulness of chemosensitivity testing using the MTT assay
Authors: Furukawa Toshiharu , Kubota Tetsuro , Suto Akihiko , Takahara Tetsuya , Yamaguchi Hiroshi , Takeuchi Tooru , Kase Suguru , Kodaira Susumu , Ishibiki Kyuya , Kitajima Masaki 
Published: February 2007

AbstractThe results of in vitro chemosensitivity testing using the MTT assay of tumor cells from 140 patients were analyzed with reference to the clinical antitumor effects of the chemotherapy. One hundred and twenty‐four (88.6%) of 140 specimens were successfully tested by the method of Mosmann (J Immunol Methods 65:55–63, 1983) with some modifications. When the results of the assay were compared with the clinical effects of chemotherapy in 22 patients with remaining measurable tumor lesions, the overall prediction rate was 86.4% (19/22). Among 31 patients with stage III‐V gastric and colorectal carcinomas without remaining measurable tumor lesions, the survival rate of nine patients treated with drugs shown to be effective in the assay was significantly (P < 0.05) better than that of 22 patients treated with drugs shown to be ineffective.
Correlation between pathological risk factors and pelvic lymph node metastases in stage I squamous carcinoma of the cervix: A multivariate analysis of 194 cases
Authors: Ayhan Ali , Tuncer Z. Selçcuk , Küçükali Türkan , Tuna Tarik , Enünlü Tayfun 
Published: February 2007

AbstractThis study includes 194 patients with stage I cervical cancer subjected to surgical therapy. Of 14 pathological factors analyzed, microscopic parametrial involvement (P = 0.001), depth of invasion (P = 0.001), and lymphovascular space invasion (P = 0.029) were found to be the most significant factors for positive pelvic lymph nodes. Combination of significant factors permitted categorization of patients into risk groups with pelvic lymph node metastases ranging from 0.0% to 90.9%.
Therapeutic effects of liposomal adriamycin in combination with tumor necrosis factor‐α
Authors: Maruo Yuji , Konno Hiroyuki , Baba Shozo 
Published: February 2007

AbstractLiposomes as drug carriers in cancer chemotherapy have attracted considerable interest. To enhance the therapeutic effect of Adriamycin entrapped in liposomes (Lip‐ADM) on human solid tumors, we investigated the therapeutic effects of Lip‐ADM in combination with recombinant human tumor necrosis factor‐α (rTNF‐α), which is known to have specific effects on tumor vasculature. rTNF‐α or saline solution was injected intravenously into nude mice bearing a human colon cancer strain, HC‐1, at 1 hour before intravenous administration of Lip‐ADM. The significant therapeutic effect of Lip‐ADM in combination with rTNF‐α was demonstrated by the evaluation with tumor growth curve and the actual tumor weights, in comparison with groups of mice treated with saline solution, rTNF‐α alone, or with a Lip‐ADM after saline. Levels of Adriamycin in tumor tissue in the Lip‐ADM in combination with rTNF‐α‐treated group were higher than those in Lip‐ADM with saline solution‐treated group.
Primary neoplasms of the small bowel
Authors: Serour Francis , Dona George , Birkenfeld Shlomo , Balassiano Moshe , Krispin Mayer 
Published: February 2007

AbstractPrimary neoplasms of the small bowel are unusual and constitute 1‐5% of all gastrointestinal tract neoplasms. Preoperative diagnostic difficulties, frequent dissemination at the time of the diagnosis, and poor prognosis are characteristic of this pathology. During a period of 26 years we treated 61 patients with tumors of the small bowel, 44 malignant and 18 benign (1 patient had both). The most common symptoms were abdominal pain (62%), weight loss (41%), and gastro‐intestinal bleeding (31%). More than half of the patients were treated as emergencies and among the remaining, the most useful diagnostic test was the small intestinal barium study. Seventeen patients were operated on for intestinal obstruction, 6 of them due to intussusception of the tumor, while 8 other patients presented with perforation and 7 with massive gastrointestinal bleeding. Leiomyoma was the most frequent benign lesion. Among malignancies lymphoma was encountered in 38.6%, followed by adenocarcinoma (29.6%) and leiomyosarcoma (22.8%). Lymphoma was predominant among Sephardic Jews. Curative procedures were attempted in all but one of the benign cases and in 21 of the malignant cases. At the time of surgery metastases were present in 23 patients. The postoperative mortality was high (20% and 14% in the benign and malignant groups, respectively) most probably due to the high incidence of emergency surgery in a high risk population. The prognosis of the malignant tumors was poor with a 5‐year survival of 18%. Their disappointing course seems to be related to late diagnosis because of nonspecific symptoms and difficulty in bringing the tumor to the fore. Hopefully, a greater awareness will lead to an earlier diagnosis and improve the prognosis.
Solitary metastases from renal cell carcinoma: A review
Authors: Tongaonkar Hemant B. , Kulkarni Jagdeesh N. , Kamat Muralidhar R. 
Published: February 2007

AbstractNineteen patients with solitary metastatic lesions from renal cell carcinoma, 5 synchronous and 14 metachronous, were seen at the Tata Memorial Hospital over a 7 year period between 1981 and 1987. The mean metastatic interval for the metachronous lesions was 31.2 months. The commonest sites of metastases were bone, lung, and liver. The solitary nature of the metastasis was confirmed by appropriate investigations. All patients underwent nephrectomy for the primary kidney lesion. The metastatic lesions were treated with intent of cure. Only 1 patient with synchronous metastasis survived for 2 years and none survived 5 years while in the metachronous metastasis group, the estimated overall survival was 50% at 2 years and 25% at 5 years. The patients with a long metastasis‐free interval were found to have a better survival. The patients with liver metastasis did poorly as compared to those with metastases at other sites. The stage of the disease also had a bearing on the survival.
Elevated CA19‐9 as the most significant prognostic factor in advanced colorectal carcinoma
Authors: Kouri Mauri , Pyrhönen Seppo , Kuusela Pentti 
Published: February 2007

AbstractTumor markers such as carcinoembryonic antigen (CEA) and CA19‐9 were analyzed as response indicators and prognostic factors in advanced colorectal carcinoma. Eighty‐five patients participated in a phase II chemotherapy study from October 1984 to July 1990. A three‐drug schedule was administered including low dose epirubicin and sequential methotrexate 5‐fluorouracil, followed by leucovorin rescue. Serum specimens for CEA and CA19‐9 were obtained prior to the initiation of chemotherapy, and subsequently at 4‐6 weeks' intervals. In univariate analysis Karnofsky, the site of the primary tumor, the extent of metastases, the presence of abdominal or liver metastases, serum CEA (cut‐off of 20 μg/1), and CA19‐9 levels correlated with survival. In stepwise multivariate analysis an elevated CA19‐9 level, a poor Karnofsky, and the presence of liver metastases were independent adverse prognostic factors. Tumors originating from the left colon had a better prognosis than the others. This was related to a higher response rate in this patient group. Serum CA19‐9 level was the most significant prognostic factor whether it was entered as a continuous or as a dichotomized variable into the model. The median survival of patients with a normal CA19‐9 level was 30.0 months (lower 95% confidence interval: 16.4 months; upper limit was not calculable), and with an elevated CA19‐9 value 10.3 months (8.0‐12.6 months, 95% confidence interval). Five of 85 patients had a complete response and 20 a partial response, the overall response rate being 29%. When compared with tumor shrinkage, “CEA response” and “CA19‐9 response” had a sensitivity of 84% and 88% and specificity of 77% and 67%, respectively. In conclusion, serum CEA value seems to be the best tumor marker for response prediction, while CA19‐9 level is one of the best available prognostic indicators in advanced colorectal carcinoma.
Increased drug resistance of cultured human cancer cell lines in three‐dimensional cellular growth assay using collagen gel matrix
Authors: Furukawa Toshiharu , Kubota Tetsuro , Watanabe Masahiko , Kase Suguru , Saikawa Yoshiro , Nishibori Hideki , Kuo Tsong‐Hong , Kodaira Susumu , Ishibiki Kyuya , Kitajima Masaki 
Published: February 2007

AbstractWe have conducted a three‐dimensional cellular growth assay using collagen gel matrix with an endpoint of the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H tetrazolium bromide (MTT) assay, on four human gastric and colonic cancer cell lines. Three‐dimensionally growing cells in collagen gel matrix were 2‐ to 180‐fold more resistant to mitomycin C, doxorubicin, 5‐fluorouracil, and cisplatin than those in monolayer culture, and these resistances were increased further when the cells increased their three‐dimensionality. Furthermore, the influence of fibroblasts in the collagen gel matrix on the chemosensitivity of cancer cells was less than that in monolayer culture. Since this new assay using collagen gel matrix with an endpoint of the MTT assay was able to detect the increase of drug resistance of human cancer cell lines by three‐dimensional cellular growth using a simple and convenient procedure, it was considered to be more useful than conventional monolayer cultures for evaluating the chemosensitivity of cancer cells.
Marginal mandibulectomy for carcinoma of the floor of the mouth
Authors: Shaha Ashok R. 
Published: February 2007

AbstractResection of primary tumors of the floor of the mouth mandates consideration of the management of the mandible which may be either involved by direct invasion or by close proximity. Segmental mandibulectomy can usually be performed when the tumor is either massive or directly invading the mandible. However, the cosmetic and functional results of segmental mandibulectomy are unsatisfactory. Whenever the tumor is close to the mandible or adherent to the periosteum, consideration should be given to marginal mandibulectomy. Over a period of 8 years, we have treated 65 patients with carcinoma of the floor of the mouth. Of these, 22 underwent marginal mandibulectomy. The number of patients staged T1, T2, and T3 were 4, 13, and 5, respectively. Most had oblique marginal mandibulectomy including the resection of the upper rim and medial cortex of the mandible. Vertical or horizontal mandibulectomy was rarely used. In each patient the preoperative workup included dental X‐rays, panoramic films, and computerized tomography (CT) scan of the head and neck. The decision as to the extent of mandibulectomy was made primarily based on the clinical judgement. Seven patients underwent marginal mandibulectomy through the open mouth. However, in the remaining 15 patients, the cheek flap approach was utilized. The defect following marginal mandibulectomy was reconstructed either with split thickness skin graft, tongue flap, or myocutaneous flap. Small defects were left open to heal by granulation and secondary intention. Split thickness skin grafts healed very well over the surface of resected mandibles. Good local tumor control was achieved at the primary site and the functional and cosmetic results were excellent.
Intravenous nitrogen mustard given immediately after mastectomy: Possible effect on local recurrence
Authors: Hines James R. 
Published: February 2007

AbstractA small group of patients with Stage I and II ductal breast carcinomas were treated with intravenous nitrogen mustard the day of mastectomy and the first two postoperative days. Long term follow‐up revealed that only one patient developed isolated local recurrence, a rate much lower than usually reported. It is possible that early use of chemotherapy could reduce local recurrences in the recently traumatized tissue.
Carcinoid tumors and inflammatory bowel disease
Authors: Kortbeek John , Kelly James K. , Preshaw Roy M. 
Published: February 2007

AbstractThree cases are described in which carcinoid tumors arose in previously established inflammatory bowel disease: two were in the ileum in cases of Crohn's disease, and one was in the rectum in a case of ulcerative colitis. Review of this association in the literature suggests that it may be more than fortuitous.
Malignant granular cell tumor of the breast
Authors: Chetty Runjan , Kalan Manhar R. 
Published: February 2007

AbstractA primary malignant granular cell tumor (MGCT) in the breast is presented. The tumor showed mitoses, pleomorphism, necrosis and regional lymph node spread. While local excision is the best form of treatment, MGCT can spread rapidly to lymph nodes, lungs, liver, and bone. This lesion is an uncommon primary malignancy of breast with only 4 other cases reported.
Cancer of the esophagus: Esophagogastric anastomotic leak—A retrospective study of predisposing factors
Authors: Patil Prakash K. , Patel Snehal G. , Mistry Rajesh C. , Deshpande Raman K. , Desai Prafulla B. 
Published: February 2007

AbstractAn esophagogastric anastomotic leak, especially in the mediastinum or the chest, is a life‐threatening complication of surgery for cancer of the esophagus. Of 617 patients who underwent esophageal resection and esophagogastric anastomosis between January 1980 and December 1989, 39 (6.32%) had anastomotic leakage; of these, 25 (64.10%) died. Various biologic parameters, operative techniques, and the management of leaks were analysed. Albumin concentration below 3 gm/dL (χ2 = 3.9; P = 0.047), neoplastic permeation of the anastomotic cut margin (χ2 = 4.7; P = 0.04), and cervical anastomosis (χ2 = 12.32; P = 0.0004) were associated with a higher incidence of anastomotic leakage. Hemoglobin level, type of suture material used for the anastomosis, preoperative radiotherapy, and the experience of the operating surgeon under supervision were found to be statistically insignificant factors and did not influence anastomotic leakage. Mortality due to leak in the first postoperative week was 85% and was statistically significant as compared to the mortality occuring in the second postoperative week (χ2 = 6.04; P = 0.013). Surgical or conservative management of the leak did not influence mortality (χ2 = 1.2; P = 0.27). The salvage rates for cervical and intrathoracic anastomotic leakage were 80% and 29.4%, respectively. This difference is statistically significant (χ2 = 29; P = 0.088).
Prostate‐specific antigen, digital rectal examination, and transrectal ultrasound in predicting the probability of cancer
Authors: Drago Joseph R. , York Jeffrey P. 
Published: February 2007

AbstractOver a 4 1/2 year period, 1,940 asymptomatic men were entered in a prostate cancer detection program consisting of digital rectal examination (DRE), prostate‐specific antigen (PSA), and transrectal prostate ultrasound (TRUS). Four hundred and sixteen biopsies were performed resulting in the diagnosis of 79 cancers; 82% had clinically organ confined tumors. A recommendation for biopsy was made in 260 (62%) based on the TRUS alone, 55 (13%) by DRE alone, 92 (22%) when the DRE and TRUS were both abnormal, and in 9 (2.2%) cases when only PSA levels were elevated. The DRE, PSA, and TRUS were abnormal in 1,261 (65%), 989 (51%), and 1,552 (80%) of the patients with cancer, respectively. Prostate cancer detection increased as the serum PSA level increased above 4 ng/ml. The positive predictive value of both DRE and TRUS were significantly influenced by an elevated PSA, (P = .042 and P < .00005, respectively). The results of this study support the idea that, although the prostate cancer detection rate is influenced by these three modalities and the detection rate of localized disease can be improved by early detection programs, its effect on mortality rates remains undefined at this time.
Chest wall resection for locally recurrent breast cancer: Indications, technique, and results
Authors: Brower Steven T. , Weinberg Hubert , Tartter Paul I. , Camunas Jorge 
Published: February 2007

AbstractA series of 100 patients with locally advanced carcinoma of the breast was analyzed for chest wall recurrence alone after primary treatment. Five patients were found to have had chest wall recurrence alone and were treated with en bloc chest wall resection. This group of patients was analyzed for the pathophysiology of recurrence including characteristics of the primary tumor, location of the chest wall recurrence, and overall local salvage and survival after chest wall recurrence. In this series, local recurrence after radical chest wall resection was 20%. The incidence of systemic recurrence after chest wall resection was 60%. The mean survival for the entire group was 17 months after chest wall recurrence and radical resection. The main surgical objectives, including relief from painful, inflammatory, and bleeding complications, were achieved in all patients after chest wall resection. Although patients with isolated chest wall recurrence included a highly selected group, chest wall resection with myocutaneous reconstruction may provide long‐term disease‐free survival for these patients.
Upper extremity occlusive arterial disease after radiotherapy for breast cancer
Authors: Atabek Umur , Spence Richard K. , Alexander James B. , Pello Mark J. , Camishion Rudolph C. 
Published: February 2007

AbstractUpper extremity arterial occlusive disease is a rare complication of radiation therapy for breast cancer. We present the case of a 74 year old woman who developed upper extremity ischemia 32 years after mastectomy and radiation therapy. Arteriography identified a stenotic proximal brachial artery lesion within the previous radiation field. Ballon angioplasty was unsuccessful. An axillo‐brachial bypass relieved the ischemia and is still patent after 24 months. The previous literature shows that arterial bypass procedures have been uniformly successful in this circumstance. Little experience has been reported with balloon angioplasty for these lesions.
Stage III breast cancer: Is neoadjuvant chemotherapy always necessary?
Authors: Frank James L. , McClish Donna K. , Dawson Kathy S. , Bear Harry D. 
Published: February 2007

AbstractOptimal management of locally advanced breast cancer is controversial. Claims of superiority for neoadjuvant systemic therapy are based on comparisons with outdated historical control groups who received no chemotherapy. Between 1978 and 1987, 118 patients with locally advanced breast cancer underwent treatment and follow‐up at the Medical College of Virginia. Median follow‐up was 44 months (range 3‐1 19 months). Actuarial 5‐year survival for the entire group was 54%. This compares favorably with recent series using neoadjuvant chemotherapy in which 5‐year survival rates of 40‐65% have been reported. Primary tumor size larger than 9 cm, metastases to more than 50% of regional lymph nodes, and the presence of inflammatory disease were significant prognostic indicators. This series represents a contemporary control group of patients with locally advanced breast cancer in whom conventionally accepted guidelines for local and postoperative systemic adjuvant therapy were used. Until the optimal sequence of therapy is determined by prospective randomized trials, series such as this may serve as more appropriate controls to which the results of new therapies could be compared. © 1992 Wiley‐Liss, Inc.
Long‐term survival in thyroid carcinoma. Patients with follicular the Oslo experience: Variations with encapsulation, growth pattern, time of diagnosis, sex, age, and previous thyroid surgery
Authors: Høie Johan , Stenwig Anna E. 
Published: February 2007

AbstractIn 98 follicular thyroid carcinoma patients with a follow‐up of 10‐32 years, 10‐year survival varied in subgroups from 15.5‐63.4%. Survival with encapsulated primary tumors was 46.7%, compared to 26.9% in widely invasive tumors, and varied from 59.9‐35.8% with growth pattern. In patients younger than 60 years of age at diagnosis 10‐year survival was 68% of expected survival, compared to 32% in patients older than 60. Patients treated after 1970 had an improved survival of 24.2%. Thirty‐one patients had previous thyroid operations for benign lesions. Review of histopathologic slides and medical records demonstrated follicular adenomas in 17 cases, and overlooked carcinomas in 11. Calculating survival from the first surgical intervention improved reported 10‐year survival by 14.5%. Papillary carcinoma patients matched for age and sex had significantly better 10‐year survival. © 1992 Wiley‐Liss, Inc.
Leptomeningeal carcinomatosis following craniofacial resection of an ethmoid tumor
Authors: Wen B‐Chen , Hussey David H. , Clamon Gerald H. , Codersky John C. 
Published: February 2007

AbstractLeptomeningeal carcinomatosis (LMC) is a rare complication following treatment for head and neck cancer. In this paper, we report a case of LMC following surgery and localized radiation therapy for an ethmoid carcinoma, in which laceration of the dura during craniofacial resection may have provided an access for cancer cells into the cerebrospinal fluid (CSF). As a result, the patient developed LMC manifested as multiple spinal nerve root involvement. The patient died 3 months after the diagnosis of LMC. To avoid this type of complication, special care must be taken to prevent tears in the dura during craniofacial resection. Also, we recommend CSF examination be performed prior to radical surgery if there is any suspicion of meningeal invasion. © 1992 Wiley‐Liss, Inc.
Simultaneous primary lung sarcoma and carcinoma
Authors: Mann Marianne , Asuncion Celedonio 
Published: February 2007

AbstractSynchronous primary lung tumors are uncommon, and primary lung sarcomas are especially rare. We report an unusual case of a poorly differentiated carcinoma and a primary sarcoma of the lung. The surgical approach to patients with synchronous primary lung tumors should be aggressive. © 1992 Wiley‐Liss, Inc.
Breast metastases from malignant melanoma
Authors: Arora Raman , Robinson William A. 
Published: February 2007

AbstractWe review here 15 patients with cutaneous malignant melanomas metastatic to the breast. All but one were premenopausal females with a median age of 38 years. Most patients had a primary lesion on the upper extremities or trunk (80%), with only one patient having a lower extremity primary. The median interval between diagnosis of the primary and breast involvement was 33 months, with one patient developing breast involvement 11 years later, at the time of her second pregnancy. Five patients had bilateral breast involvement, and all had other sites of metastases at the time of diagnosis. The median survival after diagnosis of breast metastases was 10 months, portending a poor prognosis. © 1992 Wiley‐Liss, Inc.
Postprandial hypoglycemia in islet beta cell hyperplasia with adenomatosis of the pancreas
Authors: Tibaldi Joseph M. , Lorber Daniel , Lomasky Steven , Steinberg J. J. , Reisman Robert , Shamoon Harry 
Published: February 2007

AbstractOrganic hyperinsulinism causing hypoglycemia in adults is caused by insulinoma, islet hyperplasia, or a combination of adenomata and hyperplasia. We present a patient with long‐standing symptoms of postprandial hypoglycemia occurring within 15 minutes of meals in the absence of fasting hypoglycemic symptoms. An intravenous glucagon stimulation test resulted in a rise of plasma insulin from 194 to 21,883 pmol/L at 7.5 minutes. Blood glucose simultaneously rose from 4.9 to 5.9 mmol/L. A glucose tolerance test revealed an exuberant insulin response. A euglycemic hyperinsulinemic clamp demonstrated incomplete suppression of plasma C‐peptide. At surgery, three nodules were found and a 50–60% distal pancreatectomy was performed. The pancreas revealed a combination of multiple β‐cell islet adenomata and islet hyperplasia with no evidence of nesidioblastosis. The coexistence of islet adenomata with hyperplasia must be considered in the differential diagnosis of postprandial hypoglycemia. © 1992 Wiley‐Liss, Inc.