bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulatory and Communication Shifts in Dilated Cardiomyopathy: A Multimodal Single-Cell Analysis
Authors: Tang# Yangfeng , Zhang# Jiajun , Xu# Xiangyang , Yu Yizhi , Ding Sufan , Li Bailing , Wang Guokun , Liu Xiaohong , Xu Zhiyun , Han Lin 
Published: April 2024

Abstract
Dilated cardiomyopathy (DCM), a major cause of heart failure in young adults, is characterized by ventricular dilation and progressive heart muscle dysfunction. Cellular mechanisms driving DCM have not been elucidated despite advances in genomic medicine. This study performed comprehensive multimodal single-cell analysis integrating RNA sequencing, assay for transposase-accessible chromatin with sequencing, and spatial transcriptomics data of cardiac tissues from patients with DCM and control subjects. The complex cellular heterogeneity and a novel neuro-cardiac interface were identified in DCM. The neuronal signaling pathways, including GABA receptor signaling and WT1 transcription factor activity, were profoundly dysregulated in the cardiomyocytes of patients with DCM. Cell-cell signaling analysis revealed that the communication patterns were altered, especially the upregulation of IGF and NRG signaling, suggesting a redefined role of adipocytes and lymphatic cells in DCM pathogenesis. The results of neuronal marker immunostaining analysis were consistent with those of bioinformatics analysis and indicated a potential cross-talk between cardiomyocytes and neurons. The findings of this study provided novel insights into the molecular mechanisms of DCM and identified potential therapeutic targets for DCM, which will enable the development of precision therapeutic approaches for cardiomyopathies.
Study on liquid reorientation in tank models aboard the Chinese Space Station
Authors: Chen Shuyang , Chen Shangtong , Wu Di , Duan Li , Liu Xiaozhong , Zhao Xilin , Zhang Pu , Yang Chao , Hu Liang , Wang Jia , Zhao Yifan , Yin Yongli , Kang Qi 
Published: April 2024

Abstract
Propellant tanks provide non-entrained propellant for thrusters of satellites, which plays an important role in space mission. And the fluid transfer efficiency of tanks is the key to supply non-entrained propellant. An experiment cabin containing two different scaled tank models are designed and experiments of liquid reorientation under microgravity are carried out in the Chinese Space Station. Experiment results present the high liquid transportation efficiency of the two kinds of propellant management devices. Finite element models of the two tank models are established and verified by simulation matching with experiments. Furthermore, methylhydrazine is adopted to carry out more simulation analysis by considering different liquid contact angles and surface tension, and numerical results show smaller liquid contact angle and bigger surface tension can increase liquid flow speed. This research can provide theory and data support for the design of plate type tanks.
Effect of hyperhomocysteine in patients after PCI for non-ST-segment elevation myocardial infarction, a retrospective study
Authors: Lan Kai , Gong Hui 
Published: April 2024

Abstract

Background The prognostic value of homocysteine (HCY) in patients with coronary artery disease (CAD) remains controversial. The aim of this study was to investigate whether an elevated HCY level on admission can predict long-term outcomes in patients with Non-ST-Segment elevation myocardial infarction (NSTEMI) after percutaneous coronary intervention (PCI) with coronary artery stenting.Methods From Jinshan Hospital Affiliated to Fudan University from January 2018 to December 2021, 275 patients who were diagnosed with NSTEMI and successfully underwent emergency PCI were conducted. All these patients were divided into two groups according to fasting plasma HCY levels the day after the theterization: group Ⅰ (142 patients, <15 µmol/L) and group II (127 patients, ≥ 15 µmol/L).Primary and secondary outcome measures: The primary endpoint was the occurrence of major adverse cardiac events (MACE), including cardiac death, non-fatal myocardial infarction, stroke, and new lesion stenting.Results After a mean follow-up of 36 ± 14 months, patients in group II had a higher rate of MACE (33.9% vs. 17.6%, p = 0.002). The main difference between the two groups was cardiac death (8.7% vs. 2.1%, p = 0.016). The risk of long-term MACE remained significantly higher in patients with elevated HCY levels (≥ 15 µmol/L) with a hazard ratio of 1.29 (95% CI, 1.1-12.23, p = 0.034). Elevated HCY levels (≥ 15 µmol/L) were independently associated with an increased risk of long-term cardiovascular events in patients after PCI.Conclusion Thus, hyperhomocysteinemia may remain a useful prognostic marker for risk assessment in the clinical management of CAD patients.
Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells
Authors: Tubtimsri Sukannika , Chuenbarn Tiraniti , Manmuan Suwisit 
Published: April 2024

Abstract
Background
Plant flavonoids such as quercetin are useful for both the therapeutic and preventive care of a variety of illnesses. Nevertheless, their antitumor efficacy against KON oral cancer is still unknown. Therefore, the aim of this investigation was to examine quercetin’s anti-growth, anti-migrative, and anti-invasive characteristics. The cell cycle arrest property and mitochondrial function disruption of quercetin were also investigated. Additionally, the cellular mechanism responsible for inducing apoptosis and the anti-metastasis mechanism were identified.
Methods
KON cells were treated with quercetin in order to test the anticancer activity of this compound. The MTT colorimetric assay was used to examine the cell viability of the treated cells in comparison to MRC-5 fibroblast cells. After being exposed to the detrimental effects of quercetin, the morphology of the KON cells was examined using DAPI and FDA double staining, as well as Hoechst 33258 and AO double staining. Annexin V/FITC with a flow cytometer and DCFDA labeling were used to detect apoptosis induction and the ROS production associated with cell death. Quercetin’s ability to stop the cell cycle was evaluated via PI staining and the flow cytometer. The examination included anti-proliferative, anti-migration, and anti-invasion activities. Values for the transepithelial electrical resistance, or TEER, were measured. Ultimately, the mechanisms of action of the apoptotic markers and genes implicated in the metastatic process were clarified.
Results
Quercetin treatment reduced the vitality of KON cells and had minimal effect on MRC cells. Following quercetin treatment, the characterization of apoptosis and cell death in KON cells was observed. When quercetin was applied to KON cells, the generation of ROS increased. Furthermore, it was discovered that quercetin increased the percentage of dead cells and cell cycle arrests in the S and G2/M phases. Moreover, quercetin inhibited KON cells’ capacity for migration and invasion in addition to their effects on cell stability and structure. As a result of identifying the mechanism responsible for inducing apoptosis and preventing metastasis, quercetin was found to downregulate the expression of BCL-2/BCL-XL while increasing the expression of BAX. TIMP-1 expression was upregulated while MMP-2 and MMP-9 were downregulated. Quercetin’s anticancer properties and specific mechanisms of action in relation to KON cells were clarified.
Conclusion
The results of this trial demonstrated the additional advantages of quercetin use in patients with oral cancer as a co-chemotherapeutic and preventative measure. It might therefore be applied as a viable method to eradicate oral cancer cells.
Barriers and strategies in care delivery for type 1 diabetes in Sub-Saharan Africa: a scoping review
Authors: Kentsop Herve Brice Djiofack , Zarowsky Christina , Von Oettingen Julia Elisabeth 
Published: April 2024

Abstract
Background: Type 1 diabetes is one of the most common chronic diseases in children. More than 1.2 million young people under the age of 20 are affected, the majority of whom live in low-income countries. The delivery of care for type 1 diabetes at both clinical and health system levels in Sub-Saharan Africa is an important element of protecting child health, preventing complications of type 1 diabetes, and supporting families among vulnerable populations. The successful implementation of effective care delivery requires considering a variety of obstacles and using effective and contextually appropriate strategies to overcome them. This scoping review describes and categorizes the most important barriers to type 1 diabetes care delivery in Sub-Saharan Africa and provides an overview of the types of strategies that are used to overcome these barriers.
Methods: We identified 524 articles including peer reviewed publications, gray literature, and documents from agency sites in 5 different databases published from 1990 until the end of 2020. A total of 38 articles were included in the data synthesis. The content was analyzed using a qualitative synthesis approach.
Results: Barriers to the care delivery of type 1 diabetes in Sub-Saharan Africa are related to contextual factors at several levels: health system, policy, structure and performance, patient factors, and socio-cultural factors. The core elements of successful strategies for care delivery of type 1 diabetes in Sub-Saharan Africa are education (glycemic management), staff training, and social support (social interaction).
Conclusions:Available evidence indicates that structured care delivery can improve the health of people living with type 1 diabetes in Sub-Saharan Africa. Obstacles in the case and population care delivery of type 1 diabetes and the health of people living with type 1 diabetes need to be analyzed before strategies adapted to the context and specific target groups can be developed.
rHMM: A New Regularized Algorithm-based Hidden Markov Model for High-dimensional Longitudinal Data Analysis
Authors: Leong Man Chong , Lee Ji-Hyun , Lou Xiang-Yang 
Published: April 2024

Abstract

Many real-world underlying processes, such as addiction status and its longitudinal change associated with substance use, which are influenced by multifaceted factors, are not directly observable but can be captured by competent statistical methods. Hidden Markov models (HMMs) are a powerful tool for characterizing temporal dependence and mixture of latent variables in longitudinal data analysis , whereas the current HMM approach is largely limited in high-dimensional settings due to lack of dimension reduction and variable selection techniques. This article presents a novel approach tailored to address these limitations within the framework of HMMs. To reduce bias in parameter estimation by effectively discerning and excluding insignificant covariates, we propose a two-step algorithm that integrates HMMs with regularized generalized linear models (GLMs). Initially , we combine the coordinate descent algorithm with the EM algorithm to identify significant covariates. Subsequently, we recalibrate the HMM using the selected covariates employing maximum likelihood estimation for precise parameter refinement. Simulations demonstrate our method can accurately identify significant covariates and provide unbiased estimates for both the Markov transition and GLM parameters. The proposed method has improved performance over regularized GLMs, with a false negative rate up to 38.2% lower in variable selection. In two real data analyses, our method yields meaningful results that estimate the level of persistence of the unobserved states and are consistent with the relevant studies. Additionally, it effectively selects the set of important 1 covariates. Taken together, the regularized algorithm-based HMM outperforms existing methods, offering a valuable addition to the analytical armamentarium.
Risk assessment of mine water inrush based on Semi-Supervised Deep Learning Model
Authors: Zhang Ye , Tang Shoufeng 
Published: April 2024

Abstract

To establish an effective coal mine floor water inrush prediction model, a semi-supervised model based on improved tri-training is presented. By using unlabeled data, the semi supervised model solves the limitation of limited labeled data in the water inrush dataset. Since water inrush characteristics have varying effects on accident occurrence, this paper proposes a mutual information Drop-SAE as the fundamental classifier for the semi-supervised model. The correlation between features and targets is assessed using mutual information, and features with weak correlation have their weights reset to zero to reduce the influence of irrelevant features on prediction accuracy. By contrasting water inrush incidents and model prediction results in typical North Chinese mining areas with real mining areas in Lianghuai, the superiority of this approach was confirmed. The results obtained demonstrate that, in contrast to conventional prediction techniques, the model presented in this article has an accuracy of 91.43%, whereas SAE's accuracy is 82.86%. In comparison to models that have been proposed recently (like IWOA-SVM), this model exhibits a 3% improvement in accuracy. The research results can be used in the prediction of water inrush, combining deep learning with semi-supervised models. The results have theoretical and practical significance.
2D g-GaN as Interphase Anode Layer in Mg Battery for Capturing Passivation Species (MgO, Mg(OH) 2, Mg(CO 3 ) – A First-Principles Study
Authors: Panjulingam Nandhini , Lakshmipathi Senthilkumar 
Published: April 2024

Abstract

The first principles study has been carried out to analyze the performance of the 2D graphene-Gallium Nitride (g-GaN) as interphase material at the magnesium electrode (g-GaN@Mg) for capturing the passivation species such as magnesium oxide (MgO), magnesium hydroxide (Mg(OH)2), and magnesium carbonate (MgCO3) in Rechargeable Magnesium (RMB) batteries. The current work shows that the calculated interphase binding energy (Eb) between the Mg and g-GaN layers are strong. Ab initio molecular dynamics (AIMD) simulation confirms the thermal stability of the g-GaN@Mg at 500 K. The excellent anodic properties of the g-GaN@Mg surface has been confirmed from adsorption energy and diffusivity of single Mg atom values, -2.64 eV and 10− 3 cm2/s respectively. Interaction of passivation species MgO, (Mg(OH)2) and (MgCO3) with g-GaN@Mg surface demonstrates a weakening of the Mg-O and Mg-C bond distance. The findings mentioned above suggest that the g-GaN@Mg surface is a potential protective layer against the passivation species for Mg batteries.
Estimation of pastoral load by indirect methods for a desert area with variable rainfall
Authors: Alshbaib Amal M. 
Published: April 2024

Abstract
Given the need for areas with fluctuating rainfall to continuously estimate their pastoral load and the significant effort and time this requires, which often leads to a delay in the organization of grazing there, this study suggests to using the available data to estimate the pastoral load until more accurate estimates are available.
This study used available data on the plant cover of Rawdhat As-Sabalah for the indirect estimation of pastoral load but did not perform field work.However, this study considered the sustainability of plant cover and avoided overgrazing.Therefore, the method used here to estimate the grazing load for the entire region was based on one plant species. The method estimates daily plant productivity by measuring the biomass of the daily growth rate of the vegetative part of the plant, considering the percentage of spaces between the leaves of the plant to be 50% on average. The results showed that it is possible to safely graze 41 tropical animal units in the Rawdat Al-Sabla daily during appropriate grazing periods for plants.
Field work and estimating pastoral load by direct methods remain more accurate in advance of the method in this study.However, the benefit of this method lies in reducing field effort and difficulties. This is often a reason for delaying the process of organizing grazing, and this method helps speed up the process of organizing grazing in many areas, in addition to benefiting more from the available data.
Effect of compositional variations and static-sliding indentation on Titanium based multi-phased composites and coatings
Authors: Bhattacharyya Arnab 
Published: April 2024

Abstract
Ti based composites and coatings in the form of TiAl-TaN and TiBSiC were analyzed by means of nanoindentation and scratch tests. The variation of TaN wt% in TiAl was found to get indulged in dissolution and re growth and in the process showed its diffusion barrier properties as well. The scratch adhesion tests performed showed the coating vulnerability in term positional difference in crack stability
Two Revolutions in the Destiny of the Russian Intellectual P.A. Sorokina: Individual Survival Strategy
Authors: Русанова В.С. 
Published: April 2024

На основе источников личного происхождения и публицистики анализируется индивидуальная стратегия выживания российско-американского социолога, историка П.А. Сорокина в условиях крупных общественно-политических кризисов в России начала XXв. Предпринимается попытка определить характерные черты российской интеллигенции и на конкретном примере продемонстрировать их проявление в условиях «слома эпох». Показано, что уход от взаимодействия с властью и борьбы за власть является наиболее успешной стратегией выживания, избранной ученым.
This article analyzes the individual survival strategy of the Russian-American sociologist and historian P. A. Sorokin in the conditions of major socio-political crises in Russia at the beginning of the 20th century, based on sources of personal origin and journalism. The authors try to identify the characteristic features of the Russian intelligentsia. A specific example will demonstrate the existence of the intelligentsia in the conditions of the "break of eras". The authors come to the conclusion that avoiding interaction with the authorities, from the struggle for power is the most successful survival strategy chosen by the scientist.
Alfred the Cake and the Other Heroes of British History: About One Famous Satire on School Textbook
Authors: Соколов А.Б. 
Published: April 2024

В 1930 г. в Лондоне была опубликована написанная У. Селлером и Р. Йетменом книга «1066 и все такое» – сатира на современный школьный учебник истории, остающаяся одним из самых известных произведений английской сатиры ХХ века. Содержание этого произведения рассматривается в статье. Цель исследования заключается в выявлении способов достижения комического эффекта. Обращается внимание на то, что объектом иронии для авторов было намерение научить викторианской морали. Для этого использовалась антитеза хороших/плохих королей: отрицательным примером был Карл II, и напротив, Альфред Великий был примером хорошего короля, хотя почти все, что о нем было известно из школьных учебников, носило легендарный характер. Сатира помогает понять, что власть обычно принадлежит не выдающимся личностям, а весьма ординарным и даже никчемным персонам. Другой объ-ект для сатирической критики – ложное понимание героизма. Якобы древние бритты положили начало традиции героизма. Такой подход объясняется восприятием Первой мировой войны и войн в целом, характерным для "потерянного поколения". Сатира Селлара и Йетмана показывает: традиционный урок истории был полон мифов и домыслов. Эта книга подрывает представление о единственно верной версии национальной истории, отраженной в английских школьных учебниках по истории.
A small book – satire on modern school history textbook was published in London in 1930. It was written by Walter Seller and Robert Yeatman, called “1066 and All that” and it is still one of the most famous satirical works in English literature of the XX century. The content of this writing is under regard in my article. The aim of the study lays in identification of the ways to achieve comic effect. The attention is given to the fact that for the authors the object of irony was intention to teach lesson in Victorian morality. For this the antithesis of good/ bad kings was used, and very characteristic negative example was Charles II. On the contrary Alfred the Great was an example of good king, though nearly all that was known about him from school textbooks had generally legendary character. The satire helps to understand that power usually belongs not to outstanding personalities, but to very ordinary and even worthless persons. The other object for satirical critics stands in false understanding of heroism. The ancient Britons allegedly began the tradition of heroism. This approach is explained by perception of WWI and wars in general, typical for “lost generation”. Satire of Sellar and Yeatman shows: the traditional history lesson was full of myths and speculations. This book undermined presentation about the one right version of national history as it was reflected in English school history textbooks.
“Fill the Vessel or Light the Torch” - Dilemmas of the Scientific School
Authors: Фадеева Л.А. , Вершинина Д.Б. 
Published: April 2024

В статье анализируются характерные черты и интеллектуальные традиции научной исторической школы Льва Ефимовича Кертмана, повлиявшие на развитие исследова-тельских стратегий его последователей. Первоначально, с 1960-х гг., школа складывалась как коллектив молодых исследователей, объединенных научными интересами, которые помог сформировать авторитетный ученый и харизматичный руководитель. По мере развития школы происходило расширение исследовательского поля при сохранении интеллектуальных традиций даже после неожиданной кончины в 1987 г. ее основателя. В статье использованы материалы научного и культурного наследия профессора Кертмана, литература мемуарного характера, научные публикации представителей пермской школы, посвященные как историческим сюжетам и проблемам, так и широким социокультурным вопросам. Сделать ряд выводов о значимости школы Кертмана. Авторы считают, что влияние научной школы на творчество ее последователей выразилось в фокусе на социокультурных аспектах исторического и политического процесса. Значимость научной школы авторы видят также в заданном ее основателем моральном импульсе, который помогает поддерживать исследовательский потенциал и мотивацию.
The article characterizes the specific features and intellectual traditions of the scientific historical school of Lev Kertman, which influenced the development of the research strategies of his followers. In the 1960s, the school developed as a team of young researchers united by scientific interests, which were helped to form by an authoritative scientist and charismatic leader. As the school developed, its research fields expanded while maintaining intellectual traditions even after the unexpected death of its founder in 1987. The article uses materials from the scientific and cultural heritage of Professor Kertman, literature of a memoir nature, scientific publications by representatives of the Perm school, devoted to both historical subjects and problems, and broad sociocultural issues. This gives the authors grounds to draw several conclusions about the significance of Kertman’s school. The authors believe that the influence of the scientific school was expressed in the focus on the sociocultural aspects of the historical and political process, in the fact that the person was placed at the center of the study both in history and in politics. The authors also see the significance of a scientific school in the moral impulse that was given by its founder and which helps to maintain research potential and motivation.