bluuebunny/crossref_metadata_2025_split huggingface dataset:
Joint Association of Physical Activity and Sleep Quality With Blood Pressure Control in Patients With Hypertension in Douala, Cameroon
Authors: Bika Léle Elysée Claude , Tadjoua Nenoh Audrey Liza , Mekoulou Ndongo Jerson , Ndom Ebongue Marie Solange , Tsague Kengni Hermann , Mouliom Siddick , Guessogo Wiliam Richard , Lade Viché , Kuelang Xavier , Kamdem Manuela , Siddikatou Djibrilla , Ndobo Valérie , Mandengue Samuel Honoré , Kamdem Félicité 
Published: February 2025

Introduction: Blood pressure (BP) control is necessary to prevent fatal events in patients with hypertension. Although physical activity (PA) and sleep quality (SQ) are known to reduce BP, their joint association is yet to be demonstrated. This study aimed to assess the joint association of PA and SQ on BP control among patients with hypertension in Cameroon. Methods: This was a hospital-based cross-sectional study carried out among outpatients attending Douala General Hospital in Cameroon diagnosed with hypertension. BP was considered to be controlled if it was lower than 140/90 mm Hg. PA and SQ have been assessed using the International Physical Activity Questionnaire and the Pittsburg Sleep Quality Index. Odds ratio and 95% CI have been calculated, and differences were considered significant at P < .05. Results: A total of 415 participants were recruited, the mean age was 61 (11) years, and 67% were women. Around 66.3% of participants had their BP uncontrolled. Patients with uncontrolled BP had a significantly higher proportion of overweight/obesity (87.3% vs 73.6, P = .001), sedentary time ≥ 2 hours per day (37.1% vs 27.1, P = .043), and low leisure-time PA level (39.6% vs 52.9%, P = .014). After adjustment for confounders, a poor SQ associated with a low PA level significantly increased the odds of having an uncontrolled BP (odds ratio: 2.66; 95% CI, 1.13–6.24; P = .025). Conclusion: Cameroonian patients with hypertension exhibit a high rate of poor BP control which is significantly associated with poor SQ and low PA level. These 2 parameters should be considered simultaneously for a better prevention of cardiovascular complications.
Associations between a healthy lifestyle score and retinal neurovascular health
Authors: Zeng Xiaomin , Chen Ruiye , Zhang Xiayin , Su Ting , Wang Yaxin , Hu Yijun , Shang Xianwen , Shi Danli , Yu Honghua 
Published: February 2025

AimsTo investigate the associations between a healthy lifestyle score and retinal neurovascular health, and explore whether lower inflammation levels mediate these associations.MethodsThis study is based on the UK Biobank. The healthy lifestyle score ranged from 0 to 6 and comprised physical activity, diet, sleep duration, smoking status, alcohol consumption and bodyweight. Outcomes included retinal diseases (age-related macular degeneration (AMD) and retinal vascular occlusion (RVO)) from hospital admission records (378 648 participants), retinal vascular metrics from retinal photography (32 226 participants) and retinal neural metrics from optical coherence tomography (42 557 participants). An INFLA-score was used to characterise inflammation levels.ResultsParticipants with better healthy life score (scored from 5 to 6) were associated with a 29% lower risk of AMD, 25% lower risk of RVO, 2% increase in artery-to-vein ratio (AVR), 0.22 µm increase in central retinal artery equivalent, 0.36 µm decrease in central retinal vein equivalent (CRVE), 0.004 increase in fractal dimension, 0.38 µm increase in retinal nerve fibre layer, 0.69 µm increase in ganglion cell-inner plexiform layer (GCIPL) and 0.35 µm increase in photoreceptor segment (PS) compared with those with worst lifestyle score (scored from 0 to 1) (all ptrend<0.01). In addition, INFLA-score partially mediated the associations between healthy lifestyle score and increased risk of AMD (mediated proportion (MP): 14.8%), higher AVR (MP: 12.76%), narrower CRVE (MP: 24.49%), thicker GCIPL (MP: 4.97%) and thicker PS (MP: 26.86%).ConclusionGreat adherence to a healthier lifestyle was associated with better retinal health in a dose-response manner. Lower inflammation partially mediated the association between a healthy lifestyle score and retinal health.
Impact of measles vaccination strategies on vaccination rates in low-income and middle-income countries: a systematic review and meta-analysis
Authors: Yitbarek Kiddus , Mahimbo Abela , Bobo Firew Tekle , Woldie Mirkuzie , Sheel Meru , Frawley Jane , Hayen Andrew 
Published: February 2025

IntroductionWhile many interventions aim to raise measles vaccination coverage in low-income and middle-income countries (LMICs), their overall effectiveness and cost-effectiveness are unknown. We did a review to identify and synthesise scientific research that evaluated the impact and cost-effectiveness of measles vaccination strategies on measles vaccination coverage, timeliness, hospitalisation rates, and mortality.MethodsIn this review, we searched for English-language articles published between 2012 and July 2023 in eight databases, including PubMed, ProQuest, MEDLINE (Ovid), Embase (Ovid), CINAHL, Scopus, Web of Science and the Cochrane Database of Systematic Reviews. We also included relevant grey literature sources. The review focused on studies evaluating the impact of vaccination strategies on vaccination-related outcomes in children under 5. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines throughout the process, we used Covidence software to manage most review activities. Two independent reviewers screened articles, assessed their quality using the Joanna Briggs Institute guidelines and extracted data using a predefined electronic tool. We predetermined measles vaccination coverage and timeliness as the primary outcomes, with hospitalisation and mortality as secondary outcomes. A random-effects model was employed for the meta-analysis.ResultsWe identified 44 articles, of which 14 were included in the meta-analysis. The meta-analysis indicated that vaccination-targeting interventions such as vaccination reminders, cash incentives, community engagement and health education activities increase measles vaccination coverage (RR 1.19, 95% CI 1.10 to 1.27). Our analysis also indicated that interventions such as vaccine reminders, educational programmes and incentives improved timely vaccination. Furthermore, we identified cost-effective strategies such as geographically informed microplanning, unrestricted vial opening, supplementary immunisation activities, community engagement, outreach programmes and financial incentives.ConclusionMost of the identified vaccination interventions significantly improve measles vaccination coverage and timeliness in LMICs while remaining cost-effective. Tailoring these interventions to local contexts is crucial for maximising their effectiveness in protecting children from measles and its adverse consequences.PROSPERO registration numberCRD42023433125.
Digital sleep phenotype and wrist actigraphy in individuals at clinical high risk for psychosis and people with schizophrenia spectrum disorders: a systematic review and meta-analysis
Authors: Aronica Rosario , Ostinelli Edoardo Giuseppe , Austin Charlotte , Oliver Dominic , McGuire Philip , Brambilla Paolo , Torous John , Cipriani Andrea 
Published: February 2025

AimTo identify sleep abnormalities in individuals at clinical high risk for psychosis (CHR-P) or with schizophrenia spectrum disorders (SSDs) compared with healthy controls (HCs) using wrist actigraphy, and to assess potential differences in the direction of effect with self-reported assessments of sleep.MethodsWe conducted a systematic review of observational studies, with the search last updated on 29 April 2024. Primary outcome was total sleep time (TST), with secondary outcomes including time in bed (TIB), sleep latency, sleep efficiency, wake after sleep onset, nighttime awakenings and self-reported sleep quality. Random-effects pairwise meta-analyses were used to summarise the effects of each outcome.ResultsNineteen studies were included, with 18 contributing to the meta-analyses (202 CHR-P, 584 SSD, 582 HC). TST results were inconclusive for CHR-P (MD −4.88 min (95% CI −20.57 to 10.81)), while SSD participants showed an increase in TST compared with HC (MD 106.13 min (86.02 to 124.24)). Factors such as antipsychotic medications (pseudo-R²=88.14%), age (38.89%) and gender (26.29%) partially explained the heterogeneity between subgroups. Additionally, CHR-P individuals exhibited reduced sleep efficiency (MD −2.04% (−3.55 to 0.53)), whereas SSD participants had increased TIB (MD 121.58 min (88.16 to 155.00)) and sleep latency (MD 13.05 min (2.11 to 24.00)). The risk-of-bias assessment ranged fromsome concernstohigh risk.ConclusionsOur analyses identified sleep abnormalities in CHR-P and SSD compared with placebo. However, observed heterogeneity and potential biases across studies may limit the interpretability of findings. These limitations underscore the need for standardised guidelines and more precise participant stratification.
Investigators are human too: outcome bias and perceptions of individual culpability in patient safety incident investigations
Authors: Lea William , Budworth Luke , O'Hara Jane , Vincent Charles , Lawton Rebecca 
Published: February 2025

BackgroundHealthcare patient safety investigations inappropriately focus on individual culpability and the target of recommendations is often on the behaviours of individuals, rather than addressing latent failures of the system. The aim of this study was to explore whether outcome bias might provide some explanation for this. Outcome bias occurs when the ultimate outcome of a past event is given excessive weight, in comparison to other information, when judging the preceding actions or decisions.MethodsWe conducted a survey in which participants were each presented with three incident scenarios, followed by the findings of an investigation. The scenarios remained the same, but the patient outcome was manipulated. Participants were recruited via social media and we examined three groups (general public, healthcare staff and experts) and those with previous incident involvement. Participants were asked about staff responsibility, avoidability, importance of investigating and to select up to five recommendations to prevent recurrence. Summary statistics and multilevel modelling were used to examine the association between patient outcome and the above measures.Results212 participants completed the online survey. Worsening patient outcome was associated with increased judgements of staff responsibility for causing the incident as well as greater motivation to investigate. More participants selected punitive recommendations when patient outcome was worse. While avoidability did not appear to be associated with patient outcome, ratings were high suggesting participants always considered incidents to be highly avoidable. Those with patient safety expertise demonstrated these associations but to a lesser extent, when compared with other participants. We discuss important comparisons between the participant groups as well as those with previous incident involvement, as victim or staff member.InterpretationOutcome bias has a significant impact on judgements following incidents and investigations and may contribute to the continued focus on individual culpability and individual focused recommendations observed following investigations.
TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial
Authors: Naing Aung , McKean Meredith , Tolcher Anthony , Victor Anja , Hu Ping , Gao Wei , Nogueira Filho Marco A F , Kitzing Thomas , Gleicher Stephan , Holland Daniel , Richter Emilia , Tadjalli-Mehr Keyvan , Siu Lillian L 
Published: February 2025

BackgroundM6223 is an intravenous (IV), Fc-competent, fully human, antagonistic, anti-T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains (TIGIT) antibody. Bintrafusp alfa (BA) is a bifunctional fusion protein that simultaneously blocks nonredundant immunosuppressive TGF-β and PD-(L)1 pathways.MethodsThis first-in-human, dose-escalation study in patients with advanced solid tumors (N=58; aged ≥18 years, ECOG PS≤1) evaluated M6223 alone (Part 1A, n=40; M6223 10–2400 mg every 2 weeks, n=32; M6223 2400 mg every 3 weeks, n=8) or with BA (Part 1B, n=18; M6223 300–1600 mg with BA 1200 mg; both every 2 weeks, intravenous). Primary objectives were safety, tolerability, maximum tolerated dose (MTD) and recommended dose for expansion (RDE). Additional objectives included pharmacokinetics, pharmacodynamics and clinical activity (NCT04457778).ResultsTwo dose-limiting toxicities were observed: grade 3 adrenal insufficiency (Part 1A: M6223 900 mg every 2 weeks) and grade 3 anemia (Part 1B: M6223 300 mg, only BA related). MTD was not reached. Overall, median overall survival and progression-free survival were 7.6 (95% CI 4.9, 12.0) and 1.4 (95% CI 1.3, 1.8) months, respectively. Stable disease as best response was observed in 13 (32.5%) and 5 (27.8%) patients in parts 1A and 1B, respectively. M6223±BA displayed a linear pharmacokinetic profile. Anti-TIGIT mode-of-action-related pharmacodynamic effects were observed in peripheral blood and in tumor tissue. RDEs were 1600 mg every 2 weeks or 2400 mg every 3 weeks for M6223 monotherapy and 1600+1200 mg every 2 weeks for M6223+BA.ConclusionsM6223±BA had a manageable safety profile, with RDEs defined for both monotherapy and combination therapy. Further evaluation of M6223 is ongoing in combination with the PD-L1 inhibitor avelumab in patients with advanced urothelial carcinoma (JAVELIN Bladder Medley;NCT05327530).Trial registration numberNCT04457778.
Prozac as medicine, metaphor and identity: reimagining recovery as a rhetorical process in Lauren Slater’sProzac Diary
Authors: Sanyal Swikriti , Karah Hemachandran 
Published: February 2025

This paper examines Lauren Slater’s memoir,Prozac Diary, to understand the role of language in reimagining the notion of recovery. Written from the standpoint of a consumer of antidepressant drugs,Prozac Diaryunderlines the pervasiveness of professional psychiatry’s pathologising practices and its psychopharmacological interventions in the 90s in the USA. Moreover, it unpacks the nuances of the relationship between the person and the pill at the intersections of myriad medical and socio-cultural discourses. Reading the memoir from the perspectives of disability studies scholars such as Kimberly E. Emmons and Lennard J. Davis, we argue that Slater’s use of figurative language to critically engage with the Prozac discourse is a rhetorical act of self-care. Furthermore, we contend that by normalising illness and challenging the ableist assumptions of normalcy, Slater also invests in rhetorical care of the collective self/bodymind.This paper demonstrates how through a metaphorical representation of Prozac, Slater questions the predominant mental health discourses that construct the meanings of ‘illness’ and ‘health’ and shape illness and health-based identities. Simultaneously, through her dialogical negotiations with the Prozac discourse to reconstitute a complex health identity, she raises fundamental questions about the existence of a ‘core’, ‘authentic’, ‘healthy’, pre-Prozac selfhood that the drug claims to restore. Therefore, by unravelling the intrapersonal, socio-cultural and discursive ramifications of recovery, as opposed to psychiatry’s perfunctory understanding of biological cure as a restoration of a socially desirable state of ‘normalcy’, she is able to reclaim the lived experience of recovery. We argue that inProzac Diary, recovery does not merely imply a passive internalisation of psychiatry’s biological determinism and its psychopharmaceutical approaches. Instead, it is a rhetorical process that enables the medicalised individuals to actively engage with the mental health system and interrogate the possibility of critically responding to its normative frameworks as agentic subjects.
Occupational asbestos exposure and gastrointestinal cancers: systematic review and meta-analyses
Authors: Koehoorn Mieke , McLeod Christopher B , Fan Jonathan , Arrandale Victoria H , Davies Hugh W , Dement John M , Pahwa Manisha , Peters Cheryl E , Stayner Leslie , Straif Kurt , Demers Paul A 
Published: February 2025

Objective
To conduct meta-analyses of occupational asbestos exposure and oesophageal, stomach and colorectal cancer risk, including a critical exposure assessment approach.

Methods
The search strategy was executed on MEDLINE, Embase, CINAHL, Scopus and Web of Science databases (March 2022, March 2024). Effect estimates (ORs, HRs, standardised incidence ratio and standardised mortality ratio) from eligible cohort and case-control studies were combined in random effects models. Meta-relative risks (mRRs) were calculated by cancer site and exposure characteristics. Investigators with occupational epidemiology and hygiene expertise came to a consensus on the estimates where there was confidence in significant asbestos exposure.

Results
A total of 82 (oesophageal), 153 (stomach) and 144 (colorectal) papers met the inclusion criteria. Elevated mRRs were observed for any occupational asbestos exposure for oesophageal (1.17 (95% CI 1.07 to 1.29)), stomach (1.14 (95% CI 1.05 to 1.23)) and colorectal cancer (1.16 (95% CI 1.08 to 1.24)). There was consistency of mRR estimates and higher mRRs in meta-analyses where there was increased confidence in the categorisation of highly exposed workers, including among the highest exposed workers in exposure-response studies (oesophageal: 1.63 (95% CI 1.29 to 2.06); stomach: 1.28 (95% CI 1.09 to 1.52); colorectal: 1.29 (95% CI 1.09 to 1.53)), among asbestos insulation workers (oesophageal: 1.68 (95% 1.19 to 2.36); stomach: 1.53 (95% 0.93 to 2.51); colorectal: 1.59 (95% 1.14 to 2.23)) and among workers in cohorts with a twofold or greater risk of asbestos-related lung cancer (oesophageal: 1.40 (95% CI 1.14 to 1.71); stomach: 1.33 (95% CI 1.14 to 1.56); colorectal: 1.47 (95% CI 1.34 to 1.61)).

Conclusion
The meta-analyses support a causal link between occupational asbestos exposure and the risk of oesophageal, stomach and colorectal cancer.
Tagging more quark jet flavours at FCC-ee at 91 GeV with a transformer-based neural network
Authors: Blekman Freya , Canelli Florencia , De Moor Alexandre , Gautam Kunal , Ilg Armin , Macchiolo Anna , Ploerer Eduardo 
Published: February 2025

Abstract
Jet flavour tagging is crucial in experimental high-energy physics. A tagging algorithm, - , is presented, which exploits a transformer-based neural network that is substantially faster to train than state-of-the-art graph neural networks. The algorithm uses information from particle flow-style objects and secondary vertex reconstruction for b- and c-jet identification, supplemented by additional information that is not always included in tagging algorithms at the LHC, such as reconstructed

$$K_{S}^{0}$$

K

S

0

and

$$\Lambda ^{0}$$

Λ
0

and

$$K^{\pm }/\pi ^{\pm }$$

K
±

/

π
±

discrimination. The model is trained as a multiclassifier to identify all quark flavours separately and performs excellently in identifying b- and c-jets. An s-tagging efficiency of

$$40\%$$

40
%

can be achieved with a

$$10\%$$

10
%

ud-jet background efficiency. The performance improvement achieved by including

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K

S

0

and

$$\Lambda ^{0}$$

Λ
0

reconstruction and

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K
±

/

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±

discrimination is presented. The algorithm is applied on exclusive

$$Z \rightarrow q\bar{q}$$

Z
→
q

q

¯

samples to examine the physics potential and is shown to isolate

$$Z \rightarrow s\bar{s}$$

Z
→
s

s

¯

events. Assuming all non-

$$Z \rightarrow q\bar{q}$$

Z
→
q

q

¯

backgrounds can be efficiently rejected, a

$$5\sigma $$

5
σ

discovery significance for

$$Z \rightarrow s\bar{s}$$

Z
→
s

s

¯

can be achieved with an integrated luminosity of

$$60~\text {nb}^{-1}$$

60

nb

-
1

of

$$e^{+}e^{-}$$

e
+

e
-

collisions at

$$\sqrt{s}=91.2~\textrm{GeV}$$

s

=
91.2

GeV

, corresponding to less than a second of the FCC-ee run plan at the Z boson resonance.
KSR1 mediates small-cell lung carcinoma tumor initiation and cisplatin resistance
Authors: Chatterjee Deepan , Svoboda Robert A. , Huisman Dianna H. , Drapkin Benjamin J. , Vieira Heidi M. , Rao Chaitra , Askew James W. , Fisher Kurt W. , Lewis Robert E. 
Published: February 2025

Abstract
Small-cell lung cancer (SCLC) has a dismal five-year survival rate of less than 7%, with limited advances in first line treatment over the past four decades. Tumor-initiating cells (TICs) contribute to resistance and relapse, a major impediment to SCLC treatment. Here, we identify Kinase Suppressor of Ras 1 (KSR1), a molecular scaffold for the Raf/MEK/ERK signaling cascade, as a critical regulator of SCLC TIC formation and tumor initiation in vivo. We further show that KSR1 mediates cisplatin resistance in SCLC. While 50-70% of control cells show resistance after 6-week exposure to cisplatin, CRISPR/Cas9-mediated KSR1 knockout prevents resistance in &gt;90% of SCLC cells in ASCL1, NeuroD1, and POU2F3 subtypes. KSR1 KO significantly enhances the ability of cisplatin to decrease SCLC TICs via in vitro extreme limiting dilution analysis (ELDA), indicating that KSR1 disruption enhances the cisplatin toxicity of cells responsible for therapeutic resistance and tumor initiation. The ability of KSR1 disruption to prevent cisplatin resistant in H82 tumor xenograft formation supports this conclusion. Previous studies indicate ERK activation inhibits SCLC tumor growth and development. We observe a minimal effect of pharmacological ERK inhibition on cisplatin resistance and no impact on TIC formation via in vitro ELDA. However, mutational analysis of the KSR1 DEF domain, which mediates interaction with ERK, suggests that ERK interaction with KSR1 is essential for KSR1-driven cisplatin resistance. These findings reveal KSR1 as a potential therapeutic target across multiple SCLC subtypes. Implications: Genetic manipulation of KSR1 in SCLC reveals its contribution to cisplatin resistance and tumor initiation.