bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-carbon innovation efficiency of high-tech industries and its influencing factors
Authors: Yang Qingqing , Elbakri Idris 
Published: March 2024

Abstract
China has a vast territory, with an abundance of natural resources. Industrial investment of provinces promulgating and implementing state policies and measures on the basis of the various regions and industries are slowly widening the gap, which leads to significant differences in the level of industrial development. The imbalance between development at both provincial and municipal levels has become more prominent. The state has formulated a policy of coordinated development of the regional economy. There are differences between regions and industries in the demand for technological innovation of high-tech industry. This article is from the regional perspective, industry perspective and the perspective of the two. This paper, through the research of technology innovation and output data of China’s 31 provinces, municipalities and autonomous regions, finds the delivery rate is an independent variable of the average number of employees, R&D funds, R&D internal expenditure, external spending, new product sales income, the absorption of funding expenditure, technical transformation of funds for fixed assets, and gross profit as a technological low-carbon innovation efficiency measure. Using factor analysis, multiple regression methods and SPSS software, from the perspective of two regions and industries, enables empirical analysis of the influencing factors of this variable.
Impact of uricosurics on mortality outcomes in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials
Authors: Kow Chia Siang , Ramachandram Dinesh Sangarran , Hasan Syed Shahzad , Thiruchelvam Kaeshaelya 
Published: March 2024

Abstract

Objectives
To determine risks associated with uricosurics in COVID-19 patients.

Methods
A systematic review and meta-analysis was conducted by systematically searching electronic databases.

Key findings
The pooled analysis of the included trials revealed that the use of uricosurics was not associated with the risk of mortality (pooled odds ratio [OR] = 1.03, 95% confidence interval [CI]: 0.94–1.12). However, there is a potential mortality benefit associated with the use of ascorbic acid (pooled OR = 0.78, 95% CI: 0.65–0.94).

Conclusions
The findings confirmed the safety of uricosurics in COVID-19 patients, despite their potential to cause uric acid excretion, which may possess antioxidant properties.
‘The big value of it is getting the patient seen by the right person at the right time’: clinician perceptions of the value of allied health primary contact models of care
Authors: Brandenburg Caitlin , Ward Elizabeth C , Schwarz Maria , Palmer Michelle , Hartley Carina , Byrnes Joshua , Coccetti Anne , Phillips Rachel , Wishart Laurelie R 
Published: March 2024

Abstract
Allied health primary contact clinic models of care have increasingly been used as a strategy to increase public health service capacity. A recent systematic review found little consistency or agreement on how primary contact clinics are evaluated. The concept of value of primary contact clinics, which has important implications for evaluation, has not yet been explored in-depth. To explore allied health clinicians’ perceptions of the value of allied health primary contact clinics, with the goal of informing an evaluation framework, a descriptive qualitative approach utilizing semi-structured interviews was employed. Participants included allied health staff embedded in clinical lead roles within primary contact clinics across four acute care hospitals in a metropolitan health service located in South-East Queensland, Australia. Lead staff from 30 identified primary contact clinic models in the health service were approached to take part via email. All eligible participants who provided consent were included. An inductive thematic analysis approach was used. A total of 23 clinicians (n = 23) representing 22 diverse models of primary contact clinics participated. Most participants were physiotherapists, dietitians, or occupational therapists, although speech pathology, audiology, and podiatry were also represented. Participant perceptions of the ‘value’ of PCCs were a highly complex phenomenon, comprising five intersecting domains: (i) patient satisfaction; (ii) clinical outcomes; (iii) care pathway and resource use; (iv) health service performance; and (v) staff satisfaction and professional standing. These five core value domains were positively or negatively influenced by 12 perceived benefits and 8 perceived drawbacks, respectively. Value domains were also highly interrelated and impacted upon each other. The concept of ‘value’ relating to primary contact clinics involves multiple intersecting domains encompassing different perspectives. This study highlighted potential benefits and drawbacks of primary contact clinics that have not yet been measured or explored in the literature, and as such may be useful for healthcare administrators to consider. The findings of this study will inform an evaluation framework including health economics calculator for primary contact clinics.
Testing relational turbulence theory in daily life using dynamic structural equation modeling
Authors: Goodboy Alan K , Dillow Megan R , Shin Matt , Chiasson Rebekah M , Zyphur Michael J 
Published: March 2024

Abstract
Using dynamic structural equation modeling (DSEM; Asparouhov et al., 2018), this study tests how partner disruptions of daily routines create a chaotic relational state through intensified emotions directed at partners, as posited by relational turbulence theory (RTT; Solomon et al., 2016). To test this affective process, individuals in dating relationships (N = 130) completed daily surveys for 30 days (T = 30; 3,478 total observations), measuring that day’s interference from their partner, anger experienced while interacting with their partner, and their relational turbulence. DSEM accounted for the intensive longitudinal aspects of the data while modeling three types of person-specific random effects: random intercepts to account for subject-specific averages; random slopes to account for subject-specific effects; and random variances to account for subject-specific volatility. RTT processes were supported, as greater than typical interference of routines in daily life predicted more relational turbulence that day via increased daily anger (controlling for the previous day’s levels). The use of DSEM allowed us to further test RTT by modeling person-specific inertia and volatility (for levels of interference, anger, and relational turbulence throughout a month). The use of a multilevel “location-scale” DSEM with random intercepts and random variances revealed that attachment avoidance and anxiety predicted a variety of person-specific features of the studied longitudinal processes: averages, inertia, and volatility over time. We provide our data and a supplemental primer to illustrate how to test communication theory with DSEM and model the intensive dynamics of daily life.
En route to decoloniality—A different light on Northern research on urban refugees in Southern contexts: A case from Jordan
Authors: Ghanem Hala 
Published: March 2024

Abstract
This article examines opposing viewpoints on Northern research interventions in Southern cities regarding urban refugees. While some argue for a complete boycott of Northern interventions, others perpetuate colonial attitudes of patronization. Engaging with decolonial perspectives, this article aims to bridge the gap between current practices and a desired decolonial future in refugee studies. By reflecting on personal experiences, it highlights the usually unnoticed dynamics of North–South partnerships, academic and non-academic, in refugee studies. The article explores the Northern presence in the South, focusing on Jordan. It analyses four primary trends of Northern conduct in Jordan: the shift from women empowerment to climate change, rapid out-of-touch fieldwork, the Four Seasons Phenomenon, and the add-on partners. Finally, it seeks a middle ground by providing guidance to both Northern and Southern entities, facilitating better partnerships. This article aims to raise awareness and guide experts, scholars, and INGOs in refugee studies and other disciplines.
(004) Retrospective Concomitant Nonrandomized Comparison of Testosterone Replacement Therapy Versus No Treatment for Erectile Function Post Radical Prostatectomy
Authors: Hammad M A M , Gevorkyan R , Tran J , Fung C , Barham D W , Ahlering T , Yafi F A 
Published: March 2024

Abstract

Introduction
Recent studies have shown that testosterone replacement therapy (TRT) can be safely applied in men with low-risk prostate cancer.

Objective
To assess TRT versus no TRT 2-year potency outcomes in hypogonadal men aged ≥ 60.

Methods
Retrospective concomitant nonrandomized comparison of 70 hypogonadal men, aged 60 or older, were stratified by TRT post-RP. Baseline demographics, total testosterone (TT) calculated free testosterone (cFT), and comorbidities prior to RP were measured from October 2016 – October 2020. Sexual function was assessed via the International Index of Erectile Function (IIEF-5) pre-and post-surgery. Potency (evaluated at 3-, 9-, 15-, and 24-months post-RP) was defined as erections sufficient for penetration and satisfying, and/or erection fullness &gt;75%, and/or a score of 5 on Q1 (IIEF-5; confidence). T-tests, chi-square, and regression analyses were performed.

Results
Potency at 2 years was 63.6% (TRT) versus 35.1% (No TRT; p=0.017). Regression analysis showed that TRT was a predictor of potency outcomes 2 years post-RP (OR: 3.33; 95% CI: 1.16–10.3; p=0.029) after adjusting for age and Gleason Grade Group. There were no statistically significant differences in baseline factors between the TRT-receiving and no-TRT groups. BCR rates between the two groups were 12.1% (TRT) versus 27.0% (no TRT; p=0.12) with a mean follow-up time of 40.2 ± 13.6 months. Kaplan Meier analysis demonstrated a trend toward a significant difference in time to BCR (p=0.078).

Conclusions
In hypogonadal men aged ≥ 60, TRT significantly improved potency outcomes 2-years post-RP. The risk of BCR overall in men receiving TRT was lower but not statistically significant.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: FY – Advisory board and speaker for Coloplast; consultant for Cynosure; advisory board and speaker for Halozyme; intellectual property with Masimo; advisory board for Promescent; consultant for Sprout; advisory board for Xialla.
(032) Prevalence of Testosterone Deficiency and Risk Factors in Patients with Localized Prostate Cancer After Radical Prostatectomy
Authors: Ahn S , Hwang W , Jo S B , Kim J W , Oh M M , Park H S , Moon D G 
Published: March 2024

Abstract

Introduction
Testosterone therapy (TTh) is contra-indicated in patients with prostate cancer (PCa), however according to the recent AUA guideline, TTh can be offer for localized PCa with no evidence of active disease. However, it is not known how much localized PCa patients suffer from testosterone (T) deficiency after treatment in real clinical practice, and further clinical characteristics on those potential candidates for TTh is insufficient.

Objective
This study analyzed T profile of patients with localized PCa who underwent radical prostatectomy (RP) to determined the prevalence of testosterone deficiency and its risk factors.

Methods
We reviewed patients who underwent RP for localized PCa between 2016 and 2021. Patients with less than 1 year of follow-up and patients with biochemical recurrence or distant metastasis during follow-up were excluded. In addition, we exclude the patient who had no T profile preoperatively and postoperative 1 year. The serum T level threshold for T deficiency was defined as 3.0 ng/mL. The primary outcome was the prevalence of TDS, and the secondary outcome was the predicting factors of TDS.

Results
A total of 192 patients underwent RP with localized PCa during the study period. Among them, 120 patients were analyzed, excluding patients without baseline T and follow-up T level at postoperative 1 year (n=67) and patients with BCR during the follow-up (n=5). Eighteen of 120 patients (15.0%) had T deficiency before RP. Excluding preoperative T deficiency, 33 (32.4%) of 102 patients had their T level reduced to less than 3.0 ng/ml after RP. Among them, 16 patients (15.7%) had persistent decreased T level. Table 1. Summarized the baseline characteristics of patients with and without T deficiency after RP. BMI (OR: 1.586, p&lt; 0.001) was statistically significant in multivariate logistic regression to identify the predicting factor for T deficiency after RP.

Conclusions
In the patients with localized prostate cancer, there were a significant number of TTh candidates. In particular, obese patients had a higher risk of T deficiency.

Disclosure
No.
(037) Trans Obturator Repositioning Sling (TOROS); Novel Proximal Fixation of Penile Prosthesis Cylinder in Neophallus
Authors: Raheem O , Kocjancic E , Pathuri M 
Published: March 2024

Abstract

Introduction
The placement of Penile Prosthesis (PP) in transgender men with a neophallus is technically demanding and poses challenges specifically related to the extracorporal proximal anchoring of the cylinders owing to the lack of proximal corpora. We herein designed a novel Trans-Obtutrator Repositioning Sling (TOROS) for the proximal PP cylinder anchoring in a phallus of cisgender man or a neophallus of transgender man.

Objective
To assess the safety and efficacy of this novel surgical approach for the extracorporal proximal PP cylinder anchoring (TOROS) in two patients (cisgender and transgender) through refashioned use of the AdVanceTM Male Sling System (Boston Scientific). We herein present one video (first patient) to demonstrate step by step surgical technique.

Methods
Two patients were included. First patient is a 38-year-old cisgender male with a history of micropenis who underwent anterolateral thigh phalloplasty in 2017 presents for PP insertion. Second patient is 35 year old transgender with history of right free flap forearm phalloplasty 2019 with prior failed PP revision presents with perineal pain at level of proximal PP cylinder. Both patients consented and elected to proceed.

Results
After careful identification of neophallus vascular pedicle with handheld doppler, a perineal midline incision was made. The space within the neophallus was carefully dissected, dilated up to 11mm with Hegar dilator and measured for upcoming PP cylinder. Next and similar AdVance Male Sling surgical approach, the Adductor Longus tendon identified as a landmark, a trocar was inserted carefully through the obturator foramen around the inferior ischiopubic ramus. The sling was pulled via perineal incision and refashioned into socket-like sling to house the proximal end of PP cylinder or Rear Tip Extender (RTE) (in this case). To further reinforce this connection, sling flanges wrapped around and suture fixated. Next a single-cylinder Ambicor PP (Boston Sci) is inserted. PP pump placed into the left perineal side. Total PP length was 15cm+2cm RTE. PP appeared cycling well. Skin closed in layers. Patient had an uneventful post-op course and discharged on POD #3. At the 6-week mark, the patient had no post-op complaints or complications. The patient has been able to cycle the penile implant twice daily without issue and satisfied with the outcome of the procedure.

Conclusions
Extra-corporal anchoring of PP cylinders using TOROS is a novel, feasible and potentially changing approach in cisgender or transgender men. Proximal anchoring of the cylinders on the inferior pubic ramus and ramus of the ischium through the modified and refashioned use of trans-obturator male sling mimic natural anatomical attachment of the proximal corpora, and the same approach can applied in a transgender man neophallus with apparent good stability with and without axial loading.

Disclosure
No.
(064) Argonaute 2 Restores Erectile Function by Enhancing Angiogenesis and Reducing Reactive Oxygen Species Production in Streptozotocin (STZ)-Induced Type-1 Diabetic Mice
Authors: Yin G , Ock J , Suh J , Kwon M , Limanjaya A , Ryu J 
Published: March 2024

Abstract

Introduction
Diabetes mellitus (DM), a primary cause of erectile dysfunction (ED), is a pancreatic β-cell dysfunction that leads to insulin deficiency and resistance, resulting in microvascular complications. Argonaute 2 (Ago2), a catalytic engine in mammalian RNA interference, is involved in neurovascular regeneration under inflammatory conditions.

Objective
In the present study, we aimed to determine whether an exogenous injection of Ago2 proteins can improve erectile function in STZ-induced type-1 diabetic mice and explore the specific mechanisms of Ago2 in the process.

Methods
Eight-week-old male C57BL/6 mice were used for in vivo study. The detailed mechanisms were evaluated in age-matched control or STZ-induced type-1 diabetic mice. Mouse cavernous endothelial cells and human umbilical vein endothelial cells were used for in vitro study. The function of Ago2 in high-glucose condition was evaluated by tube formation assay, migration assay, immunofluorescence stain and western blot experiments.

Results
We report that Ago2 administration can effectively improve penile erection by enhancing cavernous endothelial cell angiogenesis and survival under diabetic conditions. We found that although Ago2 is highly expressed around blood vessels and nerves, it is significantly reduced in the penis tissue of diabetic mice. Exogenous administration of the Ago2 protein restored erectile function in diabetic mice by reducing reactive oxygen species production-signaling pathways (inducing eNOS Ser1177/NF-κB Ser536 signaling) and improving cavernous endothelial angiogenesis, migration, and cell survival. Our study provides new evidence that Ago2 mediation may be a promising therapeutic strategy and a new approach for diabetic ED treatment.

Conclusions
Our study provides new insights into Ago2 function and may represent a new therapeutic approach for ED and other vascular and neurological diseases.

Disclosure
No.
(070) Assessment the Efficacy of Daily Use of Duloxetine in Treatment of Premature Ejaculation: A Prospective Randomized Placebo-Controlled Cross Over Clinical Trial
Authors: Shokr Mohamed Shokr M , Zaazaa A , Ramzy D , Yassin M , Nasr El-din M 
Published: March 2024

Abstract

Introduction
Premature ejaculation is considered to be the most common male sexual disorder, affecting 5% to 40% of sexually active men. Duloxetine is a serotonin and norepinephrine reuptake inhibitor. •It inhibits the reuptake of serotonin and norepinephrine, combining two therapeutic mechanisms in one agent to treat depression and anxiety and also raises dopamine levels.

Objective
The aim of this study is evaluating the efficacy of “daily” use of Duloxetine in treatment of PE either primary or secondary.

Methods
•This Randomized Clinical Trial enrolled among (68) Male patients had Premature ejaculation (PE) diagnosed with quantification of the intra-vaginal ejaculation latency time (IELT) less than 2 minutes. •The (68) potent male patients complaining of PE were divided into two groups: - •Intervention arm Group (A): patients with PE either primary or secondary that received (duloxetine 30mg) daily for 1 month. •Control arm Group (B): patients with PE either primary or secondary that they received placebo treatment daily for 1 month

Results
A total of 68 patients were eligible for inclusion in the current study, they had a mean age of 38.4 ± 6.1 years, secondary premature ejaculation accounted for 91.2% of the included patients. Baseline IIEF-5 showed a median of 24 (range 22–33), median AIPE was 19 (range 8–30), median IELT 60 sec (range 30–120), median Male SQOL 20 (range 15–33). •All participants had a median AIPE was 26 (range 9–34), median IELT 180 sec (range 30–240), median Male SQOL 43 (range 18–55) after being treated with duloxetine. While median AIPE after placebo was 19 (range 8–30), IELT after placebo 60 seconds (30–160), Male SQOL after placebo was 21 (range 16–33).

Conclusions
•A daily dose of Duloxetine (30 mg) had an effective role in improving premature ejaculation (PE)severity and quality of life either primary or secondary regarding

Disclosure
No.
(075) Practice Patterns of Sexual Medicine Experts Towards Postorgasmic Illness Syndrome
Authors: Duran M B , Rubin R , Reisman Y , Serefoglu E C 
Published: March 2024

Abstract

Introduction
POIS is a rare, but debilitating cluster of symptoms, occurring after ejaculation with unknown mechanism. Unfortunately, limited information is available on POIS diagnosis, treatment, and disease management

Objective
To investigate the practice patterns of sexual medicine experts towards POIS

Methods
Worldwide sexual medicine experts were invited to participate anonymously in an online, open survey using SurveyMonkey.

Results
211 sexual medicine experts filled the survey. The mean age of the participants was 45.4 years. The majority of the participants were urologists (83.9%). Most of the participants (53.5%) considered POIS to be an important sexual dysfunction that should be treated. Most participants stated that the available information about POIS was inadequate for both patients and physicians (65.9% and 66.3%, respectively). 47.9% of the participants stated psychological disorder, 46.4% stated bio-psycho-social reasons, 41.2% stated a transient deregulation of the autonomic nervous system, and 39.8% stated autoimmune or allergic type reaction for the responsibility for the pathophysiology of POIS. 56.4% of the participants stated that they would refer the patient for psychotherapy/sexual therapy to a sexologist, 41.7% would prefer antihistamine drugs to manage symptoms, and 38.4% would prefer Selective Serotonin Reuptake Inhibitor (SSRI) drugs for treatment of POIS.

Conclusions
This survey study among sexual medicine experts from different parts of the world has developed representative estimates of knowledge, attitudes and practice patterns regarding POIS worldwide. Furthermore, sexual medicine experts stated that there is not adequate information available about POIS for physicians and patients.

Disclosure
No.