bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of endoscopic ultrasound-guided hepaticogastrostomy: a meta-regression analysis
Authors: Binda Cecilia , Dajti Elton , Giuffrida Paolo , Trebbi Margherita , Coluccio Chiara , Cucchetti Alessandro , Fugazza Alessandro , Perini Barbara , Gibiino Giulia , Anderloni Andrea , Repici Alessandro , Fabbri Carlo 
Published: March 2024

Abstract
Background Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) is a valid option for EUS-guided biliary drainage that has been increasingly used in the last decade. The aims of this study were to provide a systematic review with meta-analysis and meta-regression of the features and outcomes of this procedure.
Methods The MEDLINE, Scopus, Web of Science, and Cochrane databases were searched for literature pertinent to EUS-HGS. Meta-analysis of the proportions and meta-regression of potential modifiers of the main outcome measures were applied. The main outcome was technical success; secondary outcomes were clinical success and procedure-related adverse events (AEs).
Results 33 studies, including 1644 patients, were included in the meta-analysis. Malignant biliary obstruction (MBO) was the underlying cause in almost all cases (99.6%); the main indications for EUS-HGS were duodenal/papillary invasion (34.8%), surgically altered anatomy (18.4%), and hilar stenosis (16.0%). The pooled technical success of EUS-HGS was 97.7% (95%CI 96.1%–99.0%; I
2 = 0%), the intention-to-treat clinical success rate was 88.1% (95%CI 84.7%–91.2%; I
2 = 33.9%), and procedure-related AEs occurred in 12.0% (95%CI 9.8%–14.5%; I
2 = 20.4%), with cholangitis/sepsis (2.8%) and bleeding (2.3%) the most frequent. The rate of procedure-related AEs was lower with the use of dedicated stents on univariable meta-regression analysis. Meta-regression showed that technical success and clinical success rates were modified by the centers’ experience (>4/year).
Conclusions EUS-HGS represents an effective and safe procedure for EUS-guided biliary drainage in patients with MBO. Future studies should address the impact of center experience, patient selection, and the use of dedicated stents to improve performance of this technique.
A simplified algorithm to evaluate the risk of submucosal invasive cancer in large (≥20 mm) nonpedunculated colonic polyps
Authors: O'Sullivan Timothy , Craciun Ana , Byth Karen , Gupta Sunil , Gauci Julia Louisa , Cronin Oliver , Whitfield Anthony , Abuarisha Muhammad , Williams Stephen John , Lee Eric Yong Tat , Burgess Nicholas Graeme , Bourke Michael J. 
Published: March 2024

Abstract
Background Recognition of submucosal invasive cancer (SMIC) in
large (≥20 mm) nonpedunculated colonic polyps (LNPCPs) informs selection of the optimal
resection strategy. LNPCP location, morphology, and size influence the risk of SMIC; however,
currently no meaningful application of this information has simplified the process to make it
accessible and broadly applicable. We developed a decision-making algorithm to simplify the
identification of LNPCP subtypes with increased risk of potential SMIC.
Methods Patients referred for LNPCP resection from September 2008
to November 2022 were enrolled. LNPCPs with SMIC were identified from endoscopic resection
specimens, lesion biopsies, or surgical outcomes. Decision tree analysis of lesion
characteristics identified in multivariable analysis was used to create a hierarchical
classification of SMIC prevalence.
Results 2451 LNPCPs were analyzed: 1289 (52.6%) were flat, 1043
(42.6%) nodular, and 118 (4.8%) depressed. SMIC was confirmed in 273 of the LNPCPs (11.1%). It
was associated with depressed and nodular vs. flat morphology (odds ratios [ORs] 35.7 [95%CI
22.6–56.5] and 3.5 [95%CI 2.6–4.9], respectively; P<0.001);
rectosigmoid vs. proximal location (OR 3.2 [95%CI 2.5–4.1]; P<0.001);
nongranular vs. granular appearance (OR 2.4 [95%CI 1.9–3.1]; P<0.001);
and size (OR 1.12 per 10-mm increase [95%CI 1.05–1.19]; P<0.001).
Decision tree analysis targeting SMIC identified eight terminal nodes: SMIC prevalence was 62%
in depressed LNPCPs, 19% in nodular rectosigmoid LNPCPs, and 20% in nodular proximal colon
nongranular LNPCPs.
Conclusions This decision-making algorithm simplifies
identification of LNPCPs with an increased risk of potential SMIC. When combined with surface
optical evaluation, it facilitates accurate lesion characterization and resection
choices.
Synthesis of Heteroaromatic-Fused Cyclic β-Amino Acids by Rhodium-Catalyzed Electrophilic Amination
Authors: Noda Hidetoshi , Shibasaki Masakatsu , Manoharan Ramasamy , Asada Yasuko 
Published: March 2024

AbstractA series of cyclic β-amino acids fused with heteroaromatic moieties was prepared by Rh-catalyzed electrophilic amination. The transformation involves a rhodium alkyl nitrene generated from substituted isoxazolidin-5-ones upon the N–O bond cleavage. These products contain an underexplored class of cyclic structures that may have specific applications in various chemistry disciplines.
Lanthanoids in Hydroarylaminations: Yb(III)- and Tb(III)-Catalyzed Addition of Arylamines to Activated Olefins
Authors: Kunjanpillai Rajesh , Rajesh Rajagopal , Sandhya Olencheri Karimpanakkal , Narayanan Sunilkumar Puthenpurackal 
Published: March 2024

AbstractMichael-type hydroaminations of acrylonitrile, phenyl vinyl sulfone, and dimethyl maleate were realized using arylamines catalyzed independently by Yb(OTf)3 and Tb(OTf)3 to give the desired β-aminonitriles, β-amino sulfones, and dimethyl aspartates, respectively, in moderate to excellent yields. The reactions were carried out in toluene for Yb(OTf)3 and in t-BuOMe for Tb(OTf)3, all reactions were performed at 100 °C.
Stereoselective Synthesis of Acylethenyl Tetrahydropyridino- and Deazepanopyrrolo[1,2-c]imidazolidines via Annulation of Cyclic Imines with Acylethynylpyrroles
Authors: Trofimov Boris A. , Oparina Ludmila A. , Belyaeva Kseniya V. , Kolyvanov Nikita A. , Ushakov Igor A. , Sagitova Elena F. 
Published: March 2024

AbstractA new and efficient strategy for the stereoselective synthesis of tetrahydropyridino- and deazepanopyrrolo[1,2-c]imidazolidines has been developed. Annulation of acylethynylpyrroles with six- and seven-membered cyclic imines (MeCN/THF, 20–25 °C, 24–72 h) leads to tetrahydropyrrolo[1′,2′:3,4]imidazo[1,2-a]pyridines and hexahydropyrrolo[1′,2′:3,4]imidazo[1,2-a]azepines with (E)-acylethenyl moiety in 28–96% yields.
Eye Diseases: When the Solution Comes from Plant Alkaloids
Authors: Lorrai Riccardo , Cavaterra Dario , Giammaria Sara , Sbardella Diego , Tundo Grazia Raffaella , Boccaccini Alessandra 
Published: March 2024

AbstractPlants are an incredible source of metabolites showing a wide range of biological activities. Among these, there are the alkaloids, which have been exploited for medical purposes since ancient times. Nowadays, many plant-derived alkaloids are the main components of drugs used as therapy for different human diseases. This review deals with providing an overview of the alkaloids used to treat eye diseases, describing the historical outline, the plants from which they are extracted, and the clinical and molecular data supporting their therapeutic activity. Among the different alkaloids that have found application in medicine so far, atropine and pilocarpine are the most characterized ones. Conversely, caffeine and berberine have been proposed for the treatment of different eye disorders, but further studies are still necessary to fully understand their clinical value. Lastly, the alkaloid used for managing hypertension, reserpine, has been recently identified as a potential
drug for ameliorating retinal disorders. Other important aspects discussed in this review are different solutions for alkaloid production. Given that the industrial production of many of the plant-derived alkaloids still relies on extraction from plants, and the chemical synthesis can be highly expensive and poorly efficient, alternative methods need to be found. Biotechnologies offer a multitude of possibilities to overcome these issues, spanning from genetic engineering to synthetic biology for microorganisms and bioreactors for plant cell cultures. However, further efforts are needed to completely satisfy the pharmaceutical demand.
Outpatient Prescription Opioid Use following Discharge after Deep Inferior Epigastric Perforator Breast Reconstruction with and without an Educational Intervention
Authors: Marquez Jessica L. , Chow Josh , Moss Whitney , Luo Jessica , Eddington Devin , Agarwal Jayant P. , Kwok Alvin C. 
Published: March 2024

Abstract
Background There is limited evidence for appropriate postoperative opioid prescribing in autologous breast reconstruction. We sought to describe postoperative outpatient prescription opioid use following discharge after deep inferior epigastric perforator (DIEP) breast reconstruction with and without an educational video.
Methods Patients undergoing DIEP reconstruction were given a 28-day postoperative pain and medication logbook from August 2022 to June 2023. Our practice implemented an educational video upon discharge on proper opioid consumption. Descriptive statistics on patient characteristics, intraoperative and postoperative opioid consumption, and outpatient prescription opioid use after discharge were compared between the two cohorts.
Results A total of 53 logbooks were completed with 20 patients in the no video cohort and 33 in the video cohort. On average, the days to cessation of opiates was longer in the no video cohort (8.2 vs. 5.1 days, p = 0.003). The average number of oxycodone 5 mg equivalents consumed following discharge was 13.8 in the no video cohort and 7.8 in the video cohort, which was statistically significant (p = 0.01). Overall, the percentage of opioids prescribed that were consumed in the video cohort was 28.3% versus 67.1% in the no video cohort.
Conclusion For patients discharging home after DIEP reconstruction, we recommend a prescription for 12 oxycodone 5 mg tablets. With the use of an educational video regarding proper opioid consumption, we were able to reduce the total outpatient opioid use to 5 oxycodone 5 mg tablets following hospital discharge.
The Difunctionalization of Alkenes Completed by DMTSM and CF3SO2Na without Metal Catalysts
Authors: Yan Rulong , Shen Siwei , Gao Jinzhao , Luo Xiaofeng , Wang Tianqiang , Liu Peihua 
Published: March 2024

AbstractThe electrophilic thiolation of alkenes initiated by DMTSM and the addition of CF3SO2Na in one pot has been developed. This reaction also can be extended to ArSO2Na. This protocol features a good substrate scope, simple procedures, and mild reaction conditions and affords the desired products in moderate yields without metal catalysts.
Microsurgical reconstruction of the breast: ‘The versatile lower abdomen’
Authors: Ramakrishnan Venkat V 
Published: March 2024

ABSTRACTSince the first reported use of lower abdominal tissue from the lower abdominal skin and fat by Hans Holmstrom in 1979, there have been over 300 publications on this subject. The refinements have been aimed at Ule limitation of donor mOibidity and to allow a predictable success of the transfer. This article analyses the landmarks and highlights the key developments in this area. The more recent development in this area - the Deep Inferior Epigastric Perforator flap is discussed.
Extensive Xanthomatous Change in an Ovarian Serous Borderline Tumor: More Than Just a Mere Coincidence
Authors: Koul Aakanksha , Shetty Archana , Edupuganti Hima Sree , Mysorekar Vijaya 
Published: March 2024

AbstractSerous borderline tumors of the ovary fall in between the benign and malignant category. These tumors are often diagnosed early, and the prognosis is usually favorable. However, there are variations in the histopathological findings of borderline ovarian tumors. Xanthomatous change is one such rare change in which deposition of lipid-rich material is seen morphologically as xanthoma cells within tumor tissue and reports of this are sparse. There is postulated literature on xanthomatous change being a contributing factor for progression of cancer. We present a case of a 75-year-old postmenopausal female with complaint of pain abdomen since 3 days, diagnosed radiologically as right ovarian mucinous cystadenoma/cystadenocarcinoma. Histopathology revealed a serous borderline tumor with extensive xanthomatous change. This case presents important thoughts on exploring the connection of xanthomatous change with borderline ovarian tumors, which till date is a matter of debate.
Pathophysiology, Diagnosis, and Management of Portal Hypertension in the Pediatric Population
Authors: Karuvannur Meenal Thadasina , Laique Sobia , Radhakrishnan Kadakkal , Gadani Sameer 
Published: March 2024

AbstractPortal hypertension is caused by resistance to the portal blood flow, which most commonly occurs in the setting of cirrhosis. Complications of portal hypertension can cause significant morbidity and mortality in the pediatric population. Portal hypertension is diagnosed when the hepatic venous pressure gradient (HVPG) is more than 5 mm Hg, and potential bleeding complications from esophageal and gastric varices are more likely when the HVPG is more than 10 mm Hg. Diagnosis can be made clinically; however, liver biopsy with measurement of the HVPG is ultimately required. The management of portal hypertension in pediatric patients is typically aimed at treatment of the complications. Despite the multiple pharmacologic, endoscopic, surgical, and interventional radiologic management techniques that are available, some pediatric patients will ultimately require liver transplant. Prompt referral is needed in such cases.
Portable Thomson scattering system for temporally resolved plasma measurements under low density conditions
Authors: Yamamoto N. , Yalin A. P. 
Published: March 2024

We present the development of a portable Thomson scattering diagnostic system allowing simultaneous spatially and temporally resolved plasma property measurements for low density plasmas. The setup uses a compact pulsed Nd:YAG laser (532 nm) as the light source with suppression by two volume Bragg grating notch filters and dispersion with a single-stage spectrometer before measurement with an intensified camera. A key issue is the detailed light collection and how it impacts the sensitivity and elastic light suppression, for which we have investigated two optical configurations, one based on a 7 × 1 linear fiber bundle and the other based on a slit spatial-filter. We find that the configuration with the slit spatial-filter provides a higher sensitivity by a factor of ∼2 along with more uniform spatial response. We have developed a custom pulsed-plasma setup with a modulation at 20 kHz, representative of the Hall thruster breathing mode oscillation, to show the possibility of temporally resolved measurements for electric propulsion applications. We have successfully recorded the variations in electron number density and temperature with sub-mm spatial resolution and capturing ten temporal points over the 50 µs modulation period. The detection limit of electron density (with the spatial-filter configuration) is ∼1.6 × 1017 m−3, which is ∼1/10 of the plasma density in the acceleration channel of Hall thrusters.
Laser temperature programmed desorption: A flexible technique to study ion-surface interaction
Authors: Minissale M. , Dunand A. , Hiret P. , Faure J.-B. , Grisolia C. , Angot T. , Gallais L. , Bisson R. 
Published: March 2024

Understanding the physical–chemical processes ruling the interaction of particles (atoms, molecules, and ions) with surfaces is fundamental in several research fields, such as heterogeneous catalysis, astrochemistry, and nuclear fusion. In particular, the interaction of hydrogen isotopes with plasma facing materials represents a high-priority research task in the fusion community. Such studies are essential to ensure the successful operation of experimental fusion reactors, such as the tokamak ITER. In this work, we present a surface science apparatus developed to study ion-surface interaction in fusion relevant systems. It combines laser-based techniques with contaminant-free ion/molecular beams, mass spectrometry, and surface science tools such as low-energy electron diffraction and Auger electron spectroscopy. It allows to cover a wide range of sample temperatures, from 130 to 2300 K, by changing the heating rate of samples from 0.1 to 135 K/s and maintaining the linearity of the heating ramps, a powerful feature to gain insight on adsorption, absorption, and desorption mechanisms. Experimental calibration and performance are presented in detail. Moreover, to provide a factual overview of the experimental capabilities, we focus on two different applications: the protocol used to clean a W(110) single crystal sample and the development of laser temperature programmed desorption to study helium retention in tungsten.
Women have no honour of their own
Authors: Mahmood Ansa , Ebensgaard Jensen Kim 
Published: March 2024

Abstract
This article presents a corpus-based Cultural-Linguistic study of the usage of the word honour in Pakistani and Indian Englishes, addressing underlying cultural conceptualizations of the notion of honor. Honor emerges as a complex cultural model which involves several cultural schemas, cultural categories and other cultural conceptualizations, in which women are cast as responsible protectors and upholders of the honor of men, families, and communities, their bodies being the very locus of men’s honor. The study is based on a relatively simple qualitative and quantitative analysis of two specialized corpora representing discourse on honor and related phenomena in Pakistani and Indian Englishes.
Fases y factores socioculturales en la difusión de tío/tía como vocativos
Authors: Llopis Cardona Ana , Bordería Salvador Pons 
Published: March 2024

Resumen
Este trabajo se ocupa de la difusión del cambio lingüístico a partir de un estudio de caso: la adopción de
tío/-a como vocativos contraculturales que se propagaron en el lenguaje juvenil a lo largo de las décadas 70
y 80 (Llopis y Pons 2020). El estudio se basa en una copiosa documentación, que se
interpreta a la luz de los movimientos (socio)culturales y acontecimientos históricos. Para la explicación del proceso, se parte
de la propuesta de difusión de innovaciones de Rogers (1962 [2003]) en su versión
adaptada al cambio lingüístico (Labov 1994; Croft
2000; Moreno 1998 [2009]; Blythe y Croft
2012; Nevalainen 2015). Se muestra que las innovaciones subsumidas en el
cheli forman parte de un mosaico de factores complejo, que conduce a la revisión de nociones teóricas como la del factor cultural.
En último término, pretende integrar la aproximación sociolingüística y la filológica como método válido para examinar el cambio
lingüístico con mayor profundidad y alcance.
Simultaneous interpreting, brain aging, and cognition
Authors: Elmer Stefan , Giroud Nathalie 
Published: March 2024

Abstract
Aging is associated with a high prevalence of neural and cognitive changes, which may impair life quality while placing a significant burden on the healthcare system and the economy. Nevertheless, diverse daily activities as well as deliberate
practice in several domains have been proposed to benefit brain plasticity and cognition as well as to have the potential to
counteract age-related decline through neuroprotective and/or compensatory mechanisms. In this review article, we will provide a
summary of the gray matter alterations that have commonly been documented in simultaneous interpreters over the
past twenty years. Furthermore, we will review the main literature that examined associations between simultaneous interpreting
training and cognitive functions for assessing possible practice-related cognitive benefits in older age. We will also outline
future directions for research in this area and highlight interventions aimed at mitigating the effects of aging on
neurocognition.
Predictive processes in interpreters
Authors: Hodzik Ena 
Published: March 2024

AbstractThis paper discusses predictive processes in simultaneous interpreting. A review of experimental findings in the interpreting process literature is carried out on prediction and anticipation – both instances of predictive processes – addressing two questions: (i) what causes prediction and anticipation?, and (ii) is there an experience-related advantage for prediction and anticipation in interpreters? A few gaps are identified in the literature, namely, the need for investigating language-specific cues to prediction and the need for investigating predictive behaviour in both source language processing and target language production. The review is followed by a discussion of future directions in addressing the identified gaps by interpreting process studies, as well as a discussion of how current and future experimental findings can inform our understanding of the processes underlying prediction during simultaneous interpreting.
Wearable eye trackers
Authors: Xiao Yao , Hvelplund Kristian Tangsgaard , Ho Chen-En 
Published: March 2024

Abstract
Sight interpreting/translation (SiT) refers to the mode of communication in which source language information is
received via reading and target language output is produced either in oral form or sign language. The cognitive aspect of SiT has
been examined empirically with participant-, product-, and process-oriented methods, as well as multi-method approaches. Previous
SiT research has benefitted from eye tracking technology due to the dominance of visual input during SiT. However, previous
studies have used screen-based eye trackers, where stimuli are confined to the screen, and the potential impact of elements beyond
the screen cannot be captured, leading to an oversight of the interactional aspect of SiT. Thus, we suggest wearable eye trackers
in future SiT studies to thoroughly explore the underlying cognitive mechanisms of this modality. Moreover, we argue that future
SiT studies can benefit from triangulating eye tracking data with subjective data, such as interviews, to better understand
SiT.
Contextualising translation expertise
Authors: Schlager Daniela , Risku Hanna 
Published: March 2024

Abstract
Translation expertise has been discussed intensely in (cognitive) translation studies. Most research has been
conducted in laboratory settings, attempting to discern the differences between experienced translators (‘experts’) and lesser
experienced translators. This has resulted in valuable, yet limited insights. We argue for the need to complement the picture with
a broader perspective on translation expertise and to further investigate it in its authentic dynamic contexts, be they workplaces
or other fields of practice. This implies seeing expertise as situated and performative, emerging from the interaction of social
actors with their social and material environments. Emphasis is placed on the social, discursive construction of expertise and on
the emic perspectives of the community being studied.
Empirical translation process research
Authors: Carl Michael 
Published: March 2024

Abstract
Over the last four decades, considerable efforts have been devoted to the modeling and evaluation of human
translation processes. This article takes a closer look at the evolution of empirical Translation Process Research (TPR) within
the CRITT TPR-DB tradition. It contends that human translation unfolds on various processing levels and puts forth the Free Energy
Principle (FEP) and Active Inference (AIF) as a promising framework for modeling these intricately embedded processes in a
mathematically rigorous framework.
The article introduces innovative methods for quantifying fundamental concepts of Relevance Theory (relevance,
s-mode, and i-mode translation) and establishes their connection with the Monitor Model, framing relevance maximization as a
special case of free energy minimization. The framework presents exciting prospects for future research in predictive TPR,
promising to enhance our understanding of human translation processes and contributing significantly to the broader field of
translation studies and cognitive sciences in general.