bluuebunny/crossref_metadata_2025_split huggingface dataset:
Joint Development in the South China Sea: A New Approach
Authors: Keyuan Zou 
Published: April 2006

AbstractThe political situation in the South China Sea is complicated, as it contains potential for conflict with different national interests, in particular around the Spratly Islands which are currently under multiple territorial and maritime claims. This article argues for a new proposal of joint development, at least as a provisional means, pending the settlement of the territorial and maritime disputes, involving all the parties concerned, based on the 1982 United Nations Convention on the Law of the Sea and the 2002 Declaration on the Conduct of the Parties in the South China Sea Between the Association of Southeast Asian Nations (ASEAN) and China, so as to pave the way for the sharing of resources between ASEAN members and China on the one hand and to maintain regional peace and security in East Asia on the other.
Pivotal Advance: Eosinophil infiltration of solid tumors is an early and persistent inflammatory host response
Authors: Cormier Stephania A , Taranova Anna G , Bedient Carrie , Nguyen Thanh , Protheroe Cheryl , Pero Ralph , Dimina Dawn , Ochkur Sergei I , O’Neill Katie , Colbert Dana , Lombari Theresa R , Constant Stephanie , McGarry Michael P , Lee James J , Lee Nancy A 
Published: April 2006

Abstract
Tumor-associated eosinophilia has been observed in numerous human cancers and several tumor models in animals; however, the details surrounding this eosinophilia remain largely undefined and anecdotal. We used a B16-F10 melanoma cell injection model to demonstrate that eosinophil infiltration of tumors occurred from the earliest palpable stages with significant accumulations only in the necrotic and capsule regions. Furthermore, the presence of diffuse extracellular matrix staining for eosinophil major basic protein was restricted to the necrotic areas of tumors, indicating that eosinophil degranulation was limited to this region. Antibody-mediated depletion of CD4+ T cells and adoptive transfer of eosinophils suggested, respectively, that the accumulation of eosinophils is not associated with T helper cell type 2-dependent immune responses and that recruitment is a dynamic, ongoing process, occurring throughout tumor growth. Ex vivo migration studies have identified what appears to be a novel chemotactic factor(s) released by stressed/dying melanoma cells, suggesting that the accumulation of eosinophils in tumors occurs, in part, through a unique mechanism dependent on a signal(s) released from areas of necrosis. Collectively, these studies demonstrate that the infiltration of tumors by eosinophils is an early and persistent response that is spatial-restricted. It is more important that these data also show that the mechanism(s) that elicit this host response occur, independent of immune surveillance, suggesting that eosinophils are part of an early inflammatory reaction at the site of tumorigenesis.
The tissue pentraxin PTX3 limits C1q-mediated complement activation and phagocytosis of apoptotic cells by dendritic cells
Authors: Baruah Paramita , Dumitriu Ingrid E , Peri Giuseppe , Russo Vincenzo , Mantovani Alberto , Manfredi Angelo A , Rovere-Querini Patrizia 
Published: April 2006

Abstract
Pentraxins (PTX) and complement belong to the humoral arm of the innate immune system and have essential functions in immune defense to microbes and in scavenging cellular debris. The prototypic long PTX, PTX3, and the first component of the classical complement pathway, C1q, are innate opsonins involved in the disposal of dying cells by phagocytes. Whether the interaction between various innate opsonins impacts on their function is not fully understood. We show here that characterized Toll-like receptor (TLR) ligands elicit the production of C1q and PTX3 by immature dendritic cells (DC). Moreover, these molecules bind to dying cells with similar kinetics, although they recognize different domains on the cell membranes. PTX3 binds in the fluid phase to C1q, decreasing C1q deposition and subsequent complement activation on apoptotic cells. C1q increases the phagocytosis of apoptotic cells by DC and the release of interleukin-12 in the presence of TLR4 ligands and apoptotic cells; PTX3 inhibits both events. Moreover, PTX3 inhibited the cross-presentation of the MELAN-A/melanoma antigen-reactive T cell 1 (MART-1) tumor antigen expressed by dying cells, even in the presence of C1q. These results suggest that interaction of C1q and PTX3 influences the clearance of apoptotic cells by DC. The coordinated induction by primary, proinflammatory signals of C1q and PTX3 and their reciprocal regulation during inflammation influences the clearance of apoptotic cells by antigen-presenting cells and possibly plays a role in immune homeostasis.
TNF induces distinct gene expression programs in microvascular and macrovascular human endothelial cells
Authors: Viemann Dorothee , Goebeler Matthias , Schmid Sybille , Nordhues Ursula , Klimmek Kerstin , Sorg Clemens , Roth Johannes 
Published: April 2006

Abstract
The relevance of the diversity of endothelial cells (ECs) for the response to inflammatory stimuli is currently not well defined. Using oligonucleotide microarray technique, we systematically analyzed the tumor necrosis factor (TNF)-induced expression profile in human microvascular ECs (HMEC) and macrovascular human umbilical vein ECs (HUVEC), analyzing 13,000 human genes by microarray analysis. Using strict inclusion and exclusion criteria, microarray analysis revealed that about half of the TNF-induced genes were specific for HMEC-1 or HUVEC. The microarray data could widely be confirmed by quantitative reverse transcriptase-polymerase chain reaction and at the protein level. It is interesting that the majority of those genes regulated depending on the cell type encoded for chemokines, cytokines, and cell surface molecules. Our results argue for a more careful consideration of specific effects restricted to distinct subtypes of ECs. The establishment of EC type-specific expression patterns may thus provide the basis for a selective manipulation of specific endothelial subtypes in different inflammatory diseases.
C1q and MBL, components of the innate immune system, influence monocyte cytokine expression
Authors: Fraser Deborah A , Bohlson Suzanne S , Jasinskiene Nijole , Rawal Nenoo , Palmarini Gail , Ruiz Sol , Rochford Rosemary , Tenner Andrea J 
Published: April 2006

Abstract
It has recently been recognized that the innate immune response, the powerful first response to infection, has significant influence in determining the nature of the subsequent adaptive immune response. C1q, mannose-binding lectin (MBL), and other members of the defense collagen family of proteins are pattern recognition molecules, able to enhance the phagocytosis of pathogens, cellular debris, and apoptotic cells in vitro and in vivo. Humans deficient in C1q inevitably develop a lupus-like autoimmune disorder, and studies in C1q knockout mice demonstrate a deficiency in the clearance of apoptotic cells with a propensity for autoimmune responses. The data presented here show that under conditions in which phagocytosis is enhanced, C1q and MBL modulate cytokine production at the mRNA and protein levels. Specifically, these recognition molecules of the innate immune system contribute signals to human peripheral blood mononuclear cells, leading to the suppression of lipopolysaccharide-induced proinflammatory cytokines, interleukin (IL)-1α and IL-1β, and an increase in the secretion of cytokines IL-10, IL-1 receptor antagonist, monocyte chemoattractant protein-1, and IL-6. These data support the hypothesis that defense collagen-mediated suppression of a proinflammatory response may be an important step in the avoidance of autoimmunity during the clearance of apoptotic cells.
Focus and split-intransitivity: the acquisition of word order alternations in non-native Spanish
Authors: Lozano Cristobal 
Published: April 2006

Recent unrelated studies reveal what appears to be a common acquisitional pattern in second language acquisition (SLA). While some findings show that advanced learners can indeed achieve convergent, native-like competence with formal syntactic properties (even when these are underdetermined by the input), other findings suggest that they can display divergent and even optional competence at the syntax-discourse interface with discursive properties like focus and topic. These apparently contradictory observations are not coincidental, as they can also be traced in other acquisitional studies on L1 acquisition, L1 attrition in bilinguals, child SLA and SLI (specific language impairment). If this pattern is correct, it should be observed in the L2 acquisition of any given property that is simultaneously governed by both a formal grammatical constraint and a discursive constraint. I tested whether this is the case in advanced non-native Spanish acquisition of the syntactic distribution of subject-verb (SV) and verb-subject (VS) word order, which is constrained by both a formal syntactic property (the Unaccusative Hypothesis or Split-intransitivity Hypothesis) and a property at the syntax-discourse interface (presentational focus). Results show that the interlanguage grammars (ILGs) of both English ( n = 17) and Greek ( n = 18) learners of Spanish converge with the grammars of native Spanish speakers ( n = 14) when formal properties are involved, yet they diverge (in particular by showing optionality) with discursive focus. These results confirm the emerging view that acquisition of formal syntactic properties is more readily acquired than discourse properties, which are persistently problematic.
Enantioselective Aerobic Epoxidation of Acyclic Simple Olefins Catalyzed by the Optically Active β-Ketoiminato Manganese(III) Complex
Authors: Nagata Takushi , Imagawa Kiyomi , Yamada Tohru , Mukaiyama Teruaki 
Published: April 2006

Abstract
Enantioselective aerobic epoxidation of acyclic cis-olefins into the corresponding optically active epoxides was carried out with good-to-high enantioselectivities by using a new class of optically active β-ketoiminato manganese(III) complex catalyst, N,N′-ethylenebis(α-mesitoyl-β-ketoiminato)manganese(III) chloride. The key intermediate of the present epoxidation is also discussed.
Sugar-Assisted Chirality Control of Tris(2,2′-bipyridine)-Metal Complexes
Authors: Nakashima Kazuaki , Shinkai Seiji 
Published: April 2006

Abstract
2,2′-Bipyridine-4,4′-diboronic acid (2), a 2,2′-bipyridine derivative with sugar-binding sites was synthesized. The Δ vs. Λ chirality of the Fe2+·23 complex was selectively generated in correlation with the absolute configuration of added saccharides.
Ring Hydroxylations of Aromatic Amino Acid Derivatives and Toluene by Hydrogen Peroxide Catalyzed by Manganese Halogenated Porphyrins in CH2Cl2/H2O and Lipid Bilayers
Authors: Iida Kouji , Nango Mamoru , Okada Kenichi , Matsumoto Shunichi , Matsuura Mitsutaka , Yamashita Keiji , Tsuda Kazuichi , Kurono Yukihisa , Kimura Yoshikazu 
Published: April 2006

Abstract
Manganese fluorinated porphyrins catalyzed the ring hydroxylation of phenylalanine derivatives and toluene with H2O2 and an enhanced hydroxylation was observed especially in phospholipid bilayers when imidazole was present. The hydroxylation depended upon the structures of porphyrins and substrates.
Crystal-Chemical Factors Responsible for the Distribution of Octahedral Cations Over trans- and cis-Sites in Dioctahedral 2:1 Layer Silicates
Authors: Drits Victor A. , McCarty Douglas K. , Zviagina Bella B. 
Published: April 2006

AbstractCrystal chemical analysis of various dioctahedral 2:1 phyllosilicates consisting of trans-vacant (tv) and cis-vacant (cv) layers and interstratified cv and tv layers shows that there is compositional control over the distribution of octahedral cations over trans and cis sites. Fe3+ and Mg-rich dioctahedral micas (celadonite, glauconite, leucophyllite and most phengite) occur only as tv varieties. Similarly, the occurrence of tv illites and tv illite fundamental particles in illite-smectite (I-S) does not depend significantly on the cation composition of the 2:1 layers. In contrast, compositional restrictions exist to control the occurrence of pure cv1M illite, which can form only as Fe- and Mg-poor varieties. Similarly, proportions of cv and tv layers in illite fundamental particles depend on the amount of Al in octahedral and tetrahedral sheets of the 2:1 layers.Simulations of atomic coordinates and interatomic distances for periodic tv1M and cv1M illite structures allow us to reveal the main structural factors that favor the formation of cv layers in illite and I-S. It is shown that in contrast to the tv1M structure, interlayer K in cv1M illite has an environment which is similar to that in 2M1 muscovite. This similarity along with a high octahedral and tetrahedral Al content probably provides stability for cv1M illite in low-temperature natural environments. Because of structural control, the occurrence of monomineral cv1M illite, its association with tv 1M illite, and interstratified cv-tv illite fundamental particles is confined by certain physical and chemical conditions. These varieties are most often formed by hydrothermal activity of different origin. The initial material for their formation should be Al-rich and the hydrothermal fluids should be Mg- and Fe-poor. They occur mostly around ore deposits, in bentonites and in sandstone sedimentary rocks.The factors governing the formation of tv and cv layers in dioctahedral smectite are probably related to the layer composition and local order-disorder in the distribution of isomorphous octahedral cations, because there is no influence from fixed interlayer cations. In particular, the occurrence of Mg-OH-Mg cation arrangements is more favorable for the formation of cv montmorillonite layers.
Nickel Solubility and Precipitation in Soils: A Thermodynamic Study
Authors: Peltier Edward , Allada Ramakumar , Navrotsky Alexandra , Sparks Donald L. 
Published: April 2006

AbstractThe formation of mixed-metal-Al layered double hydroxide (LDH) phases similar to hydrotalcite has been identified as a significant mechanism for immobilization of trace metals in some environmental systems. These precipitate phases become increasingly stable as they age, and their formation may therefore be an important pathway for sequestration of toxic metals in contaminated soils. However, the lack of thermodynamic data for LDH phases makes it difficult to model their behavior in natural systems. In this work, enthalpies of formation for Ni LDH phases with nitrate and sulfate interlayers were determined and compared to recently published data on carbonate interlayer LDHs. Differences in the identity of the anion interlayer resulted in substantial changes in the enthalpies of formation of the LDH phases, in the order of increasing enthalpy carbonate<sulfate<nitrate. Substitution of silica for carbonate resulted in an even more exothermic enthalpy of formation, confirming that silica substitution increases the stability of LDH precipitates. Both mechanical mixture and solid-solution models could be used to predict the thermodynamic properties of the LDH phases. Modeling results based on these thermodynamic data indicated that the formation of LDH phases on soil mineral substrates decreased Ni solubility compared to Ni(OH)2 over pH 5–9 when soluble Al is present in the soil substrate. Over time, both of these precipitate phases will transform to more stable Ni phyllosilicates.
Heating Fe Oxide-Rich Soils Increases the Dissolution Rate of Metals
Authors: Perrier Nicolas , Gilkes Robert J. , Colin Fabrice 
Published: April 2006

AbstractEvidence for fire affecting the solubility of metals in Fe oxide-rich Oxisols of the Koniambo Massif of New Caledonia is presented. Acid-dissolution studies showed that Ni, Al and Cr are substituted for Fe in the structure of the Fe oxides. Thermal dehydroxylation of goethite under oxidizing conditions led to the formation of hematite and to the migration of some of these metals towards the surface of hematite crystals as indicated by their enhanced release during the early stage of dissolution. Dehydroxylation of goethite under reducing conditions led to the formation of hematite and maghemite. Nickel and Al were released preferentially during the early stages of dissolution whereas Cr was not released preferentially and may be uniformly incorporated within maghemite and hematite crystals. These results have significance to the mineral-processing industry, to geochemical exploration and to the availability of these metals to plants growing on burnt soils.
Thermal and Mineral Properties of Al-, Cr-, Mn-, Ni- and Ti-Substituted Goethite
Authors: Wells M. A. , Fitzpatrick R. W. , Gilkes R. J. 
Published: April 2006

AbstractMineralogical and thermal characteristics of synthetic Al-, Cr-, Mn-, Ni- and Ti-bearing goethites, synthesized via alkaline hydrolysis of metal-ferrihydrite gels, were investigated by powder X-ray diffraction and differential thermal analysis. Shifts in unit-cell dimensions were consistent with size of substituent metal ions and confirmed the incorporation of Al3+, Cr3+, Mn3+, Ni2+ and Ti4+ in the goethite structure. A weight loss of 6.2 wt.% for goethite containing 12.2 mol.% Ti, being significantly less than for stoichiometric goethite, is consistent with the replacement of Fe by Ti in the goethite structure coupled with the substitution of O2− ions for OH− (i.e. proton loss). These data provide the first confirmation of the direct replacement of Fe by Ti within goethite. Formation of multiple dehydroxylation endotherms for goethite containing 4.5 mol.% Al, 15.3 mol.% Mn and 12.2 mol.% Ti was not attributed to the decomposition of surface OH groups or related simply to the crystallinity of precursor goethite (‘high-a’ vs. ‘low-a’) as defined by the magnitude of a. Instead, endotherm doublet formation was associated with weight loss due to the dehydroxylation of goethite remaining after initial phase transformation to protohematite and to the evolution of OH− associated with the rapid increase in crystallite size of protohematite directed primarily along the a direction. Development of the first endotherm is due to initial dehydroxylation and transformation to protohematite. With continued heating of well ordered goethite or goethite containing moderate to high levels of substituent cations, domain growth along the a direction is delayed or inhibited to a critical point that provides enough thermal energy to enable goethite transformation to proceed to completion and for proto-hematite domain growth to occur. This results in the formation of a second endotherm. For less well ordered goethite and/or goethite containing only low levels of foreign metal cations, protohematite domain growth is not inhibited and proceeds continuously with heating to give only a single endotherm.
Comparisons of Structural Fe Reduction in Smectites by Bacteria and Dithionite: An Infrared Spectroscopic Study
Authors: Lee Kangwon , Kostka Joel E. , Stucki Joseph W. 
Published: April 2006

AbstractThe reduction of structural Fe in smectite is mediated either abiotically, by reaction with dithionite, or biotically, by Fe-reducing bacteria. The effects of abiotic reduction on clay-surface chemistry are much better known than the effects of biotic reduction. Since bacteria are probably the principal agent for mediating redox processes in natural soils and sediments, further study is needed to ascertain the differences between biotic and abiotic reduction processes. The purpose of the present study was to compare the effects of dithionite (abiotic) and bacteria (biotic) reduction of structural Fe in smectites on the clay structure as observed by infrared spectroscopy. Three reference smectites, namely, Garfield nontronite, ferruginous smectite (SWa-1), and Upton, Wyoming, montmorillonite, were reduced to similar levels by either Shewanella oneidensis or by pH-buffered sodium dithionite. Each sample was then analyzed by Fourier transform infrared spectroscopy (FTIR). Parallel samples were reoxidized by bubbling O2 gas through the reduced suspension at room temperature prior to FTIR analysis. Redox states were quantified by chemical analysis, using 1, 10-phenanthroline. The reduction level achieved by dithionite was controlled to approximate that of the bacterial reduction treatment so that valid comparisons could be made between the two treatments. Bacterial reduction was achieved by incubating the Na-saturated smectites with S. oneidensis strain MR-1 in a minimal medium including 20 mM lactate. After redox treatment, the clay was washed four times with deoxygenated 5 mM NaCl. The sample was then prepared either as a self-supporting film for OH-stretching and deformation bands or as a deposit on ZnSe windows for Si-O stretching bands and placed inside a controlled atmosphere cell also fitted with ZnSe windows. The spectra from bacteria-treated samples were compared with dithionite-treated samples having a similar Fe(II) content. The changes observed in all three spectral regions (OH stretching, M2-O-H deformation, and Si-O stretching) for bacteria-reduced smectite were similar to results obtained at a comparable level of reduction by dithionite. In general, the shift of the structural OH vibration and the Si-O vibration, and the loss of intensity of OH groups, indicate that the bonding and/or symmetry properties in the octahedral and tetrahedral sheets changes as Fe(III) reduces to Fe(II). Upon reoxidation, peak positions and intensities of the reduced smectites were largely restored to the unaltered condition with some minor exceptions. These observations are interpreted to mean that bacterial reduction of Fe modifies the crystal structures of Fe-bearing smectites, but the overall effects are modest and of about the same extent as dithionite at similar levels of reduction. No extensive changes in clay structure were observed under conditions present in our model system.
Identification of Neoformed Ni-Phyllosilicates Upon Ni Uptake in Montmorillonite: A transmission Electron Microscopy and Extended X-ray Absorption Fine Structure Study
Authors: Dähn Rainer , Jullien Michel , Scheidegger André M. , Poinssot Christophe , Baeyens Bart , Bradbury Michael H. 
Published: April 2006

AbstractThe aim of this work was to investigate whether neoformed Ni-phyllosilicates can be observed and identified using transmission electron microscopy (TEM) in combination with energy dispersive spectroscopy (EDS). The investigations focused on Ni-phyllosilicates formed from Ni-doped montmorillonite. The reaction conditions (pH 8, [Ni]initial = 660 and 3300 µM, 0.2 M Ca(NO3)2) employed were similar to those used in previous polarized extended X-ray absorption fine structure (P-EXAFS) investigations of neoformed Ni-phyllosilicates in a Ni-montmorillonite system.The TEM investigations of Ni-doped montmorillonite revealed the presence of small, thin particles consisting of coherent stacks that yielded only three to five lattice fringes with spacings consistent with smectites. These small particles were neoformed phyllosilicates, based on the fact that the small particles were only observed in Ni-doped samples and their Ni content, as determined from EDS analysis, was high (up to 10 wt.% NiO). Furthermore, the particles did not possess the characteristic properties of montmorillonite particles, such as a 2:1 Si to Al ratio; instead these particles were rich in Si (up to 75 wt.% SiO2). Unlike montmorillonite, these particles did not contain any Fe. The particles were also significantly more resistant to electron beam damage than montmorillonite particles, and EXAFS measurements confirmed the presence of neoformed Ni-phyllosilicates.The TEM study further indicates the presence of a variety of additional minerals (e.g. cristobalite, halloysite) and an X-ray amorphous Si-rich phase. A Ni signal could only be detected in the latter phase at high Ni loadings (403 µmol/g), suggesting that Ni uptake at low metal loadings (<90 µmol/g) is mainly controlled by the neoformation of phyllosilicates.