bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discrimination Against Women Reconsidered
Authors: Niemi Albert W. 
Published: July 2006

AbstractSexist earnings differences must not be confused with wage discrimination; wage discrimination against females is only one source of the large sexist earnings gap. The author agrees that his calculations of adjusted earnings ratios do not capture all changes in relative productivity between male and female workers.His present value estimates compared male and female earnings during entire productive lives, from labor market entrance to retirement. Hence they do reflect earnings variations at all age levels and thus the average experience of females with comparable educational attainment.
Ethnicity and Economic Opportunity
Authors: Stewart James B. , Hyclak Thomas 
Published: July 2006

AbstractIn this analysis, data from the 1970 Census of Population are used to determine whether ethnic discrimination has been an important factor contributing to differential economic performance among immigrant groups. The measures of economic performance employed in this investigation are mean family income and the extent of poverty among cohorts of immigrants. Stepwise multiple regression analysis is used to select among possible influences on these measures of economic performance. Dummy variables are defined in a manner that allows the impact of discrimination on economic performance to be measured directly. The results of this analysis support the hypothesis that discrimination against particular groups has been a major contributing factor to differential economic performance among groups. As a consequence, we are led to reject the competing explanation of differential economic performance advanced by some analysts that differentials in economic performance merely reflect skill differentials among groups.
Alternative Methods of School Finance: An Empirical Analysis of Cities in San Diego County
Authors: Popp Dean , Vogt Walter 
Published: July 2006

Abstract. Two alternatives to the local school property tax are explored using a simulation model: a power equalizing property tax and a state‐wide property tax. The effects on residents’tax burdens and service levels are estimated and compared for residents of 13 cities in San Diego County. Under each of the available options shifts in tax burdens would occur. One high income city is a major beneficiary. Three others which would be required to contribute more to education are otherwise dissimilar; one is already taxing itself heavily. When tax effort is considered, cities intended to be prime beneficiaries do benefit but not greatly. The principal gainer is a city with high income and high property values. This analysis does not indicate that these alternative programs are more equitable than the present property tax.
Public Choice and Land Tax Fairness
Authors: Lindholm Richard W. 
Published: July 2006

Abstract Land value taxation (LVT) as desirable U.S. tax policy was brilliantly set forth by the American publicist and economist, Henry George, in the book Progress and Poverty, published 100 years ago. Economists concerned with state and local taxation have generally accepted the basic elements of George's analysis. The absence of substantial LVT legislation despite the economic efficiency and ethical strengths of land as a tax base arises from two sources. First, the public perception of land has not separated land's attributes from those possessed by other property. Second, land ownership data have not been gathered and publicized. Groups favoring taxes that promote economic justice and efficiency should support efforts to develop land ownership data. It would be an important first step toward fully utilizing the potential of LVT.
Frank Knight on Preachers and Economic Policy: A 19th Century Liberal Anti Religionist, He Thought Religion Should Support the Status Quo
Authors: Kern Williams S. 
Published: July 2006

Abstract. A central feature of the work of American economist and social philosopher Frank H. Knight was his antagonism toward organized religion, particularly Christianity and especially Catholicism. Knight's antagonism towards the Church may be traced to his historical views on the Liberal Revolution and the opposition of the Church to critical inquiry and open discussion, and its support for despotic social institutions. Additionally, Knight's antagonism stemmed from his skepticism about the possibilities of effective social reforms based upon Christian moral principles. Knight found little in Christian teaching that would offer appropriate solutions—certainly not the “Gospel of Love” which he took as the core of Christian social teachings. Furthermore he was critical of the reform efforts of preachers because of their ignorance of the function of the free market and their propensity towards radical solutions. On the centennial of his birth, he is remembered as an ardent social critic and a liberal supporter of the status quo.
Christianity had a reasonably fair trial at ordering the world and individual life for a ‘millenium’ or so, and the result was very different from the Kingdom of God on earth.Frank H. Knight
The Anti‐Benthamism of J. M. Keynes: Implications for The General Theory
Authors: Mini Peter V 
Published: July 2006

Abstract Keynes severely criticized the “Benthamite tradition,” the overvaluation of the “economic criterion” He found “the love of money” corrosive of community and esthetic values and an encouragement to reckless exploitation of places that should be in the public domain In “Art and the State,” he proposes the rebuilding of large sections of modern cities to rekindle popular feelings of beauty and community valuesOne of the factors behind this philosophy was G E Moore's Principia Ethica (1903) It criticizes Bentham for committing “the naturalistic fallacy” of confusing means with ends and idealizes two “goods” in themselves, the pleasure of human relations and the enjoyment of beauty in nature and art These ideals Keynes saw undermined by the Benthamite traditionSuch criticism is the “moral‐political paradigm” on which The General Theory is erected Minute calculation of advantages and disadvantages, on which classical economics is based, is rejected Behind consumption and investment functions are sociological and psychological factors, “animal spirits,” and the like Calculation prevails in the stock and bond markets (liquidity preference)–to everybody's sorrow The proposed slow elimination of institutions that make liquidity preference possible, and of the rentier, follow logically Econometrics, viewed as the tool of the overvaluation of the economic criterion, is also rejected. In many articles Keynes aimed at much more than revolutionizing political economy, he aimed at weaning England from Benthamite utilitarianism and raising the cultural values of the populace By 1938 he knew that he had failed.
Effects of 3- and 5-Year Treatment With Risedronate on Bone Mineralization Density Distribution in Triple Biopsies of the Iliac Crest in Postmenopausal Women
Authors: Zoehrer Ruth , Roschger Paul , Paschalis Eleftherios P , Hofstaetter Jochen G , Durchschlag Erich , Fratzl Peter , Phipps Roger , Klaushofer Klaus 
Published: July 2006

Abstract
Long-term effects of risedronate on bone mineralization density distribution in triple transiliac crest biopsies of osteoporotic women were evaluated. In this double-blinded study, 3- and 5-year treatment with risedronate increased the degree and homogeneity of mineralization without producing hypermineralization. These changes at the material level of bone could contribute to risedronate's antifracture efficacy.
Introduction: Risedronate, a nitrogen-containing bisphosphonate, is widely used in the treatment of osteoporosis. It reduces bone turnover, increases BMD, and decreases fracture risk. To date, there are no data available on the long-term effects of risedronate on bone mineralization density distribution (BMDD) in humans.
Materials and Methods: Osteoporotic women enrolled in the VERT-NA trial received either risedronate (5 mg/day, orally) or placebo for up to 5 years. All subjects received calcium and vitamin D supplementation if deficient at baseline. Triple iliac crest biopsies were collected from a subset of these subjects at baseline and 3 and 5 years. BMDD was measured in these biopsies using quantitative backscattered electron imaging, and the data were also compared with a normal reference group.
Results: At baseline, both risedronate and placebo groups had a lower degree and a greater heterogeneity of mineralization as well as an increase in low mineralized bone compared with the normal reference group. The degree of mineralization increased significantly in the risedronate as well as in the placebo group after 3- and 5-year treatment compared with baseline. However, the degree of mineralization did not exceed that of normal. Three-year treatment with risedronate significantly increased the homogeneity of mineralization and slightly decreased low mineralized bone compared with placebo. Surprisingly with 5-year risedronate treatment, heterogeneity of mineralization increased compared with 3-year treatment, which might indicate an increase in newly formed bone.
Conclusions: Long-term treatment with risedronate affects the homogeneity and degree of mineralization without inducing hypermineralization of the bone matrix. These changes at the material level of the bone matrix may contribute to risedronate's antifracture efficacy in osteoporotic patients.
Strontium Ranelate Reduces the Risk of Vertebral and Nonvertebral Fractures in Women Eighty Years of Age and Older
Authors: Seeman Ego , Vellas Bruno , Benhamou Claude , Aquino Jean Pierre , Semler Jutta , Kaufman Jean Marc , Hoszowski Krzysztof , Varela Alfredo Roces , Fiore Carmelo , Brixen Kim , Reginster Jean Yves , Boonen Steven 
Published: July 2006

Abstract
Strontium ranelate produces an early and sustained reduction of both vertebral and nonvertebral fractures in patients ≥80 years of age.
Introduction: About 25–30% of the population burden of all fragility fractures in the community arise from women ≥80 years of age, because this population is at high risk for all types of fracture, particularly nonvertebral fractures. Despite this, evidence that therapies reduce the risk of both vertebral and nonvertebral fractures in this group is lacking. The aim of this study was to determine whether strontium ranelate, an agent that reduces the risk of vertebral and nonvertebral fractures in postmenopausal women &gt;50 years of age, also reduces fractures in the elderly.
Materials and Methods: An analysis based on preplanned pooling of data from two international, phase III, randomized, placebo-controlled, double-blind studies (the Spinal Osteoporosis Therapeutic Intervention [SOTI] and TReatment Of Peripheral OSteoporosis [TROPOS]) included 1488 women between 80 and 100 years of age followed for 3 years. Yearly spinal X-rays were performed in 895 patients. Only radiographically confirmed nonvertebral fractures were included.
Results: Baseline characteristics did not differ in placebo and treatment arms. In the intent-to-treat analysis, the risk of vertebral, nonvertebral, and clinical (symptomatic vertebral and nonvertebral) fractures was reduced within 1 year by 59% (p = 0.002), 41% (p = 0.027), and 37% (p = 0.012), respectively. At the end of 3 years, vertebral, nonvertebral, and clinical fracture risks were reduced by 32% (p = 0.013), 31% (p = 0.011), and 22% (p = 0.040), respectively. The medication was well tolerated, and the safety profile was similar to that in younger patients.
Conclusions: Treatment with strontium ranelate safely reduces the risk of vertebral and nonvertebral fractures in women with osteoporosis ≥80 years of age. Even in the oldest old, it is not too late to reduce fracture risk.
A Novel Mutation (K378X) in the Sequestosome 1 Gene Associated With Increased NF-κB Signaling and Paget's Disease of Bone With a Severe Phenotype
Authors: Rea Sarah L , Walsh John P , Ward Lynley , Yip Kirk , Ward Bryan K , Kent G Neil , Steer James H , Xu Jiake , Ratajczak Thomas 
Published: July 2006

Abstract
Sequestosome 1/p62 (p62) mutations are associated with PDB; however, there are limited data regarding functional consequences. We report a novel mutation in exon 7 (K378X) in a patient with polyostotic Paget's disease of bone. p62 mutants increased NF-κB activation and significantly potentiated osteoclast formation and bone resorption in human primary cell cultures.
Introduction: Sequestosome 1/p62 (p62) mutations are associated with Paget's disease of bone (PDB); however, there are limited data regarding functional consequences. One report has linked the common P392L mutation in the p62 ubiquitin binding associated (UBA) domain with increases in NF-κB activity, a transcription factor essential for osteoclastogenesis. To further clarify the functional impact of p62 mutations associated with PDB, we assessed the effect of p62 mutation (a novel mutation: K378X, and previously reported mutations: P392L and E396X) on RANK-induced NF-κB activation and compared this with the effect of wildtype p62. In addition, we studied the effect of p62 mutation on osteoclast formation and bone resorption.
Materials and Methods: We performed co-transfection experiments with expression plasmids for p62 (wildtype or mutated) and RANK and an NF-κB luciferase reporter gene. Luciferase activities were recorded after addition of luciferin to cellular lysates. RAW264.7 cells stably expressing enhanced green fluorescent protein (EGFP)-tagged p62 (wildtype, K378X, or P392L) or EGFP alone were assessed for changes in cell proliferation. Additionally, these cells were stimulated with RANKL to produce osteoclast-like cells (OLCs). Primary human monocytes collected from the K378X-affected patient and a control subject were stimulated to form OLCs and bone resorption data were obtained.
Results: The novel mutation introduces a premature stop codon in place of Lys-378 and thereby eliminates the entire p62 UBA domain; this and two additional natural mutations (P392L, E396X) increased NF-κB activation compared with wildtype p62. Wildtype p62 consistently inhibited NF-κB activation compared with empty vector. UBA mutations (K378X and P392L) significantly increased the number of OLCs formed in response to RANKL and also the number of nuclei of the OLCs. K378X-affected human monocytes formed more OLCs with more nuclei and increased bone resorption compared with control monocytes.
Conclusions: Our data show that mutation of the p62 UBA domain results in increased activation of NF-κB and osteoclast formation and function compared with wildtype p62. These results may partially explain the mechanism by which p62 mutation contributes to the pathogenesis of PDB.
Fluid Shear Stress Induces Less Calcium Response in a Single Primary Osteocyte Than in a Single Osteoblast: Implication of Different Focal Adhesion Formation
Authors: Kamioka Hiroshi , Sugawara Yasuyo , Murshid Sakhr A , Ishihara Yoshihito , Honjo Tadashi , Takano-Yamamoto Teruko 
Published: July 2006

Abstract
The immediate calcium response to fluid shear stress was compared between osteocytes and osteoblasts on glass using real-time calcium imaging. The osteoblasts were responsive to fluid shear stress of up to 2.4 Pa, whereas the osteocytes were not. The difference in flow-induced calcium may be related to differences in focal adhesion formation.
Introduction: To explore the immediate response to mechanical stress in a bone cell population, we examined flow-induced calcium transients. In addition, the involvement of focal adhesion-related calcium transients in response to fluid flow in the cells was studied.
Materials and Methods: Bone cells were isolated from 16-day-old embryonic chicken calvaria by serial treatment with EDTA and collagenase. Single cells on glass without intercellular connections were subjected to fluid flow, and intracellular calcium concentration was measured using imaging with fluo-3. The identification of cell populations in the same field was performed with a chick osteocyte-specific antibody, OB7.3, and an alkaline phosphatase substrate, ELF-97, for osteoblast identification afterward. Immunofluorescence staining of vinculin was performed to visualize focal adhesions.
Results: The percentage of cells responding to fluid shear stress at 1.2 Pa was 5.5% in osteocytes, 32.4% in osteoblasts, and 45.6% in OB7.3/ELF-97-negative cells. Furthermore, osteoblasts and OB7.3/ELF-97-negative cells were more responsive to 2.4 Pa than 1.2 Pa, whereas osteocytes were less responsive. The elevation of calcium transients over baseline did not show any significant differences in the populations. To elucidate the mechanism accounting for the fact that single osteocytes are less sensitive to fluid shear stress of up to 2.4 Pa than osteoblasts, we studied focal adhesion-related calcium transients. First, we compared focal adhesion formation between osteocytes and osteoblasts and found a larger number of focal adhesions in osteoblasts than in osteocytes. Next, when the cells were pretreated with GRGDS (0.5 mM) before flow treatment, a significant reduction of calcium transients in osteoblasts (18%) was observed, whereas calcium transients in osteocytes were not changed by GRGDS. Control peptide GRGES did not reduce the calcium transients in either cell type. Furthermore, we confirmed that osteoblasts in calvaria showed a marked formation of vinculin plaques in the periphery of the cells. However, osteocytes in calvaria showed faint vinculin plaques only at the base of the processes.
Conclusions: On glass, single osteocytes are less sensitive to fluid shear stress up to 2.4 Pa than osteoblasts. The difference in calcium transients might be related to differences in focal adhesion formation. Shear stress of a higher magnitude or direct deformation may be responsible for the mechanical response of osteocytes in bone.
Disease Status in Autosomal Dominant Osteopetrosis Type 2 Is Determined by Osteoclastic Properties
Authors: Chu Kang , Snyder Richard , Econs Michael J 
Published: July 2006

Abstract
Asymptomatic gene carriers and clinically affected ADO2 subjects have the same ClCN7 mutation. We examined osteoclastic bone resorption in vitro as well as osteoclast formation, several markers, acid secretion, and cytoskeletal structure. We found that ADO2 expression results from osteoclast specific properties.
Introduction: Autosomal dominant osteopetrosis type II (ADO2) is a heritable osteosclerotic disorder that results from heterozygous mutations in the ClCN7 gene. However, of those individuals with a ClCN7 mutation, one third are asymptomatic gene carriers who have no clinical, biochemical, or radiological manifestations. Disease severity in the remaining two thirds is highly variable.
Materials and Methods: Human peripheral blood mononuclear cells were isolated and differentiated into osteoclasts by stimulation with hRANKL and human macrophage-colony stimulating factor (hM-CSF). Study subjects were clinically affected subjects, unaffected gene carriers, and normal controls (n = 6 in each group). Pit formation, TRACP staining, RANKL dose response, osteoclast markers, acid secretion, F-actin ring, and integrin αvβ3 expression and co-localization were studied.
Results: Osteoclasts from clinically affected subjects had severely attenuated bone resorption compared with those from normal controls. However, osteoclasts from unaffected gene carriers displayed similar bone resorption to those from normal controls. In addition, the resorption lacunae from both unaffected gene carriers and normal controls appeared much earlier and spread much more rapidly than those from clinically affected subjects. As time progressed, the distinction between clinically affected subjects and the other two groups increased. No significant difference was found in acidic secretion or osteoclast formation between the three groups. Osteoclast cytoskeletal organization showed no difference between the three groups but there was low cellular motility in clinically affected subjects.
Conclusions: Osteoclasts from the unaffected gene carriers, in contrast to those from the clinically affected subjects, functioned normally in cell culture. This finding supports the hypothesis that intrinsic osteoclast factors determine disease expression in ADO2. Further understanding of this mechanism is likely to lead to the development of new approaches to the treatment of clinically affected patients.
Bone Morphogenetic Proteins in Bone Stimulate Osteoclasts and Osteoblasts During Bone Development
Authors: Okamoto Mina , Murai Junko , Yoshikawa Hideki , Tsumaki Noriyuki 
Published: July 2006

Abstract
In this study, overexpression of noggin, a BMP antagonist, in developing bone caused significantly decreased osteoclast number as well as bone formation rate, resulting in increased bone mass with immature bone quality. BMP signaling plays important roles in normal bone development and regulation of bone resorption.
Introduction: Bone morphogenetic proteins (BMPs) act on various types of cells. Although involvement of BMP signals in osteoblast differentiation has been studied extensively, the effects of BMPs on osteoclasts have not been widely researched. Consequently, the net effects of BMPs on bone remain unclear. The purpose of this study was to delineate more fully the role of BMPs in skeletal biology.
Materials and Methods: We generated transgenic mice that express BMP4 or noggin in bone under the control of the 2.3-kb α1(I) collagen chain gene (Col1a1) promoter, and analyzed their bone phenotype. We also analyzed bone of transgenic mice expressing BMP4 specifically in cartilage.
Results: Mice overexpressing BMP4 in bone developed severe osteopenia with increased osteoclast number. Mice overexpressing noggin, a BMP antagonist, in bone showed increased bone volume associated with decreased bone formation rate and decreased osteoclast number. The noggin-transgenic tibias exhibited reduced periosteal bone formation and reduced resorption of immature bone in marrow spaces, associated with frequent fractures at the diaphysis. Co-culture of primary osteoblasts prepared from noggin-transgenic calvariae and wildtype spleen cells resulted in poor osteoclast formation, which was rescued by addition of recombinant BMP2, suggesting that noggin inhibits osteoclast formation by attenuating BMP activities in noggin-transgenic mice. The expression levels of Rankl were not decreased in primary osteoblasts from noggin transgenic mice. Immunoblot analysis showed increased phosphorylation of Smad1/5/8 in osteoclast precursor cells after 20-minute treatment with BMPs, suggesting that these cells are stimulated by BMPs. Mice overexpressing BMP4 in cartilage had enlarged bones containing thick trabeculae, possibly because of expansion of cartilage anlagen.
Conclusions: Overexpression of noggin in bone revealed that BMP signals regulate bone development through stimulation of osteoblasts and osteoclasts.