bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central retinal artery occlusion and non-arteritic anterior ischemic optic neuropathy associated with an overlap syndrome: a case report
Authors: Lima Verônica C , Prata Tiago S , Liebmann Jeffrey M , Ritch Robert 
Published: January 2009

Abstract

Introduction
An "overlap syndrome" is defined as the sequential appearance over time of two or more risk factors for glaucomatous damage. The appearance of a new risk factor can alter the course and prognosis of previously stable disease. Exfoliation syndrome is a leading cause of glaucoma and is associated with vascular disease. We report a case of central retinal artery occlusion and non-arteritic anterior ischemic optic neuropathy in a patient with overlap syndrome.

Case presentation
An 87-year-old woman with longstanding stable primary open-angle glaucoma developed bilateral exfoliation syndrome, after which her intraocular pressure became uncontrolled and her glaucomatous damage progressed rapidly. She also developed ischemic arterial events in both eyes.

Conclusion
The case presented here shows that overlap syndromes can lead to rapid, irreversible vision impairment. To the best of our knowledge, this is the first reported case of central retinal artery occlusion and non-arteritic anterior ischemic optic neuropathy in a patient with overlap syndrome.
Minimally invasive treatment of patients with bronchobiliary fistula: a case series
Authors: Aydin Unal , Yazici Pinar , Tekin Fatih , Ozutemiz Omer , Coker Ahmet 
Published: January 2009

Abstract

Introduction
Bronchobiliary fistula is an uncommon complication secondary to hepatobiliary surgery. Bilioptysis is a pathognomic finding for bronchobiliary fistulas. Diagnosis may be easily established in the light of clinical history, which can be aided by imaging studies to pinpoint the exact location. Some diagnostic procedures such as endoscopic retrograde cholangiopancreatectomy are also useful for treatment.

Case presentation
We present three Turkish patients with bronchobiliary fistula secondary to previous hepatic surgery due to hydatid cyst in two, a 19-year-old and a 47-year-old man, and iatrogenic trauma of the common bile duct by endoscopy in a 35-year-old man. All of the patients were successfully treated by minimally invasive methods including percutaneous drainage and endoscopic retrograde cholangiopancreatography.

Conclusion
We suggest that bronchobiliary fistula could be managed through conservative treatment methods which do not require in-hospital follow-up, particularly in uncomplicated cases. Otherwise, surgical management can be unavoidable.
Chest pain and ST-segment elevation in a patient with polymyositis: a case report
Authors: Stougiannos Pavlos N , Mytas Dimitrios Z , Katsaros Andreas A , Kakkavas Apostolos T , Androulakis Aristides E , Kallikazaros Ioannis E , Chrissos Dimitrios N 
Published: January 2009

Abstract

Background
Cardiac involvement in patients with polymyositis is well-documented and includes myocarditis, coronary arteritis, pericarditis, valvular dysfunction and arrhythmias.

Case report
There are only few reports of acute myocarditis in patients with polymyositis and, although it usually follows a chronic, mild course, it may occasionally become life-threatening. We describe the case of a 36-year-old young woman suffering from polymyositis who presented with clinical signs and symptoms mimicking an ST Elevation Acute Coronary Syndrome. The atypical features of the pain, the young age of the woman, the lack of significant cardiovascular risk factors and the medical history of an autoimmune disease, led us to reconsider our initial diagnosis towards the presence of focal myocarditis.

Conclusion
We describe our diagnostic approach and comment on our speculations and decisions about the treatment of such a life threatening event.
Expiratory automatic endotracheal tube compensation reduces dynamic hyperinflation in a physical lung model
Authors: Haberthür Christoph , Mehlig Annekathrin , Stover John F , Schumann Stefan , Möller Knut , Priebe Hans-Joachim , Guttmann Josef 
Published: January 2009

Abstract
Introduction
The effect of expiratory endotracheal tube (ETT) resistance on dynamic lung inflation is unknown. We hypothesized that ETT resistance causes dynamic lung hyperinflation by impeding lung emptying. We further hypothesized that compensation for expiratory ETT resistance by automatic tube compensation (ATC) attenuates dynamic lung hyperinflation.

Methods
A ventilator equipped with the original ATC mode and operating in a pressure-targeted mode was connected to a physical lung model that consists of four equally sized glass bottles filled with copper wool. Inspiratory pressure, peak expiratory flow, trapped lung volume and intrinsic positive end-expiratory pressure (PEEP) were assessed at combinations of four inner ETT diameters (7.0, 7.5, 8.0 and 8.5 mm), four respiratory rates (15, 20, 25 and 30/minute), three inspiratory pressures (3.0, 4.5 and 6.0 cmH2O) and four lung compliances (113, 86, 58 and 28 ml/cmH2O). Intrinsic PEEP was measured at the end of an expiratory hold manoeuvre.

Results
At a given test lung compliance, inspiratory pressure and ETT size, increasing respiratory rates from 15 to 30/minutes had the following effects: inspiratory tidal volume and peak expiratory flow were decreased by means of 25% (range 0% to 51%) and 11% (8% to 12%), respectively; and trapped lung volume and intrinsic PEEP were increased by means of 25% (0% to 51%) and 26% (5% to 45%), respectively (all P < 0.025). At otherwise identical baseline conditions, introduction of expiratory ATC significantly attenuated (P < 0.025), by approximately 50%, the respiratory rate-dependent decreases in inspiratory tidal volume and the increases in trapped lung volume and intrinsic PEEP.

Conclusions
In a lung model of pressure-targeted ventilation, expiratory ETT resistance caused dynamic lung hyperinflation during increases in respiratory rates, thereby reducing inspiratory tidal volume. Expiratory ATC attenuated these adverse effects.
Liver X Receptor Ligands Suppress Ubiquitination and Degradation of LXRα by Displacing BARD1/BRCA1
Authors: Kim Kang Ho , Yoon Jeong Min , Choi A Hyun , Kim Woo Sik , Lee Gha Young , Kim Jae Bum 
Published: January 2009

Abstract
Liver X receptor (LXR) is a ligand-activated transcription factor that plays important roles in cholesterol and lipid homeostasis. However, ligand-induced posttranslational modification of LXR is largely unknown. Here, we show that ligand-free LXRα is rapidly degraded by ubiquitination. Without ligand, LXRα interacts with an ubiquitin E3-ligase protein complex containing breast and ovarian cancer susceptibility 1 (BRCA1)-associated RING domain 1 (BARD1). Interestingly, LXR ligand represses ubiquitination and degradation of LXRα, and the interaction between LXRα and BARD1 is inhibited by LXR ligand. Consistently, T0901317, a synthetic LXR ligand, increased the level of LXRα protein in liver. Moreover, overexpression of BARD1/BRCA1 promoted the ubiquitination of LXRα and reduced the recruitment of LXRα to the target gene promoters, whereas BARD1 knockdown reversed such effects. Taken together, these data suggest that LXR ligand prevents LXRα from ubiquitination and degradation by detaching BARD1/BRCA1, which might be critical for the early step of transcriptional activation of ligand-stimulated LXRα through a stable binding of LXRα to the promoters of target genes.
Disposition of MDMA and Metabolites in Human Sweat Following Controlled MDMA Administration
Authors: Barnes Allan J , De Martinis Bruno S , Gorelick David A , Goodwin Robert S , Kolbrich Erin A , Huestis Marilyn A 
Published: January 2009

Abstract
Background: Understanding the excretion of 3,4-methylenedioxymethamphetamine (MDMA) and metabolites in sweat is vital for interpretation of sweat tests in drug treatment, criminal justice, and workplace programs.
Methods: Placebo, low (1.0 mg/kg), and high (1.6 mg/kg) doses of oral MDMA were given double-blind in random order to healthy volunteers (n = 15) with histories of MDMA use. Participants resided on the closed clinical research unit for up to 7 days after each dose. Volunteers wore PharmChek® sweat patches (n = 640) before, during, and after controlled dosing. Patches were analyzed by solid phase extraction and GC-MS for MDMA, methylenedioxyamphetamine (MDA), 4-hydroxy-3-methoxyamphetamine (HMA), and 4-hydroxy-3-methoxymethamphetamine (HMMA). Limits of quantification (LOQ) were 2.5 ng/patch for MDMA and 5 ng/patch for HMA, HMMA, and MDA.
Results: MDMA was the primary analyte detected in 382 patches (59.7%), with concentrations up to 3007 ng/patch. MDA was detected in 188 patches (29.4%) at &lt;172 ng/patch, whereas no HMMA or HMA was detected; 224 patches (35.0%) and 60 patches (9.4%) were positive for MDMA and MDA, respectively, at the 25-ng/patch threshold proposed by the Substance Abuse and Mental Health Services Administration.
Conclusions: Sweat testing was shown to be an effective and reliable method for monitoring MDMA use in this controlled MDMA administration study. However, variability in sweat excretion suggests that results should be interpreted qualitatively rather than quantitatively. These data provide a scientific database for interpretation of MDMA sweat test results.
A Review on Modeling and Simulation of Quenching
Authors: Şimşir Caner , Gür C. Hakan 
Published: January 2009

Abstract
Modeling and simulation of quenching are powerful tools in the design, optimization, and understanding of the quenching process since they provide quantitative results such as the evolution of microstructure and the internal stresses, which are practically impossible to acquire experimentally. The research on simulation of quenching and related phenomena originates from the early 70s and is still an active field owing to its industrial and scientific output. This paper aims to provide a comprehensive review of those studies and to present the state of the art with a discussion of limitations and drawbacks of contemporary models with an emphasis on the complementary steps that have to be taken in collaboration with the industry.
Embryotoxicity of retene in cotreatment with 2-aminoanthracene, a cytochrome P4501A inhibitor, in rainbow trout (Oncorhynchus mykiss)
Authors: Scott Jason A. , Ross Meagan , Lemire Ben C. , Hodson Peter V. 
Published: January 2009

AbstractEnvironmentally relevant mixtures of polycyclic aromatic hydrocarbons (PAHs; e.g., crude oils) are often rich in alkyl-PAHs, such as retene (7-isopropyl-1-methylphenanthrene), which produce dioxin-like toxicity in fish embryos. The mechanism of alkyl-PAH toxicity is not well understood but was previously thought to be mediated by cytochrome P4501A (CYP1A) enzymes. To understand the role of CYP1A in retene toxicity, we coexposed free-swimming rainbow trout (Oncorhynchus mykiss) embryos to 100 μg/L of retene and to a range of concentrations of 2-aminoanthracene (2AA; a known CYP1A inhibitor). Ethoxyresorufin-O-deethylase (EROD) assays of juvenile trout coexposed to 2AA and retene confirmed that 2AA inhibited CYP1A (median inhibitory concentration [IC50] for 2AA, 62 μg/L). In two independent trials, 2AA, both alone and in cotreatment with retene, produced a concentration-dependent increase in toxicity to embryonic trout. The toxicity resulting from 2AA alone is, to our knowledge, the first reported for embryonic stages of fish, with median lethal concentrations (LC50s) of 19 and 125 μg/L and overall sublethal median effective concentrations (EC50s) of 17 and 38 μg/L. Toxicity increased in embryos coexposed to retene and 2AA, resulting in LC50s of 14 and 17 μg/L of 2AA and overall EC50s of 7 and 3 μg/L of 2AA. The exposure-response curves for 2AA alone and for 2AA with retene were parallel, suggesting a common mode of action between the two treatment regimes and between retene and 2AA. Taken together with the juvenile EROD data, the toxicity of 2AA alone and in cotreatment with retene may be EROD (CYP1A) independent. The mixture toxicity was not consistent with previous coexposures to CYP1A inducers and inhibitors, suggesting that the current risk assessment model may not be a good predictor of PAH mixture toxicity.
Pattern of Occurrence of Single and Concurrent Diseases Associated with Mortality in Commercial Chickens in Bangladesh
Authors: Rahman MA , Samad MA 
Published: January 2009

The high mortality rate of commercial poultry has been encountered as a major problem which discourage farmers and entrepreneurs in this industry in Bangladesh. This study was carried out to determine the role of single and concurrent infections associated with mortality in 1751 commercial chickens during one year period from January to December 2002. Diagnosis of diseases was made on the basis of history, necropsy findings, isolation and identification of causative bacteria and other laboratory tests. The etiological investigations of 1751 dead chickens showed that about 39.81% bacterial, 22.73% viral, 13.65% mycoplasmal, 1.54% fungal, 10.11% parasitic, 31.64% systemic, 3.43% nutritional deficiency and 1.77% other diseases were associated with these mortality. Salmonellosis (21.99%), Colibacillosis (8.40%), Fowl cholera (6.52%), Avian mycoplasmosis (13.65%), Infectious bursal disease (11.20%), Newcastle disease (10.34%) and coccidiosis (6.23%) were recognized as major diseases associated with mortality in commercial chickens in Bangladesh. About 32 diseases were recorded, of which both single (76.30%) and mixed infections as two (21.53%), three (1.83%) and four (0.34%) types were associated with mortality of chickens. Significantly (p < 0.01) highest proportionate mortality rate was recorded in > 20 weeks old adult layer (45.52%) in comparison to > 2 to 8 weeks old grower (24.04%), > 8 to 20 weeks old pullet (18.16%) and up to 2 weeks old brooding (12.28%) chickens. Seasonal influence showed highest mortality rate during Summer (43.06%) in comparison to Rainy (27.81%) and Winter (29.13%) seasons. It may be concluded from this study that both the single and concurrent infections are associated with high mortality rate in commercial chickens in Bangladesh. Therefore, the interactions of different pathogens in naturally occurring diseases should be considered during diagnosis and evaluation of vaccination.Â Â Key words: Occurrence; concurrent; mortality; diseases; chickens DOI = 10.3329/bjvm.v1i1.1911 Bangl. J. Vet. Med. (2003). 1 (1) : Â 15 - 20
Seasonal Influence on The Occurrence of <i>Haemonchus contortus</i> Infection in Slaughtered Black Bengal Goats in Bangladesh
Authors: Shahiduzzaman M , Alim MA , Rahman M , Mondal MMH 
Published: January 2009

Seasonal influence on the occurrence of Haemonchus contortus parasite was studied on 672 slaughtered Black Bengal goats during one year period from July 2002 to June 2003. An overall 65.63% goats had H. contortus infection and significantly (p < 0.01) higher infection rate was recorded in female (70.43%) than male (58.61%) goats. A positive correlation between the occurrence of H. contortus infection and climatic factors was recorded. Significantly (p < 0.01) highest infection rate of H. contortus was recorded during rainy (72.57 %) season in comparison to summer (66.46%) and winter (51.54%) seasons. The infection was recorded at the peak in July (84.42%) and lowest in January (46.15%). The load of H. contortus per abomasum varied significantly (p < 0.05) in different months of the year and an average maximum number of parasites per abomasum was recorded in July (41.25) and the minimum in March (5.52). In case of sex ratio of the parasites always the female (60.73%) were found to be dominated over the males (39.27%) parasites.Â Â Â Key words: Seasonal influence; Haemonchus contortus; Black Bengal goat; Bangladesh DOI = 10.3329/bjvm.v1i1.1917 Bangl. J. Vet. Med. (2003). 1(1) : 45 - 48
Religious and spiritual issues in medical genetics
Authors: Fanning Joseph B. , Clayton Ellen Wright 
Published: January 2009

AbstractThis article provides an overview of a special issue on the religious and spiritual concerns that arise in the provision of genetic services. It introduces some of the challenges in defining religion and spirituality and provides contexts and summaries for the empirical and normative research that appears in the issue. © 2009 Wiley‐Liss, Inc.
A religious framework as a lens for understanding the intersection of genetics, health, and disease
Authors: Harris Tina M. , Keeley Bethany , Barrientos Samantha , Gronnvoll Marita , Landau Jamie , Groscurth Christopher R. , Shen Lijiang , Cheng Youyou , Cisneros J. David 
Published: January 2009

AbstractThe primary goal of this study was to determine the extent to which religious frameworks inform lay public understandings of genes and disease. Contrary to existing research, there were minimal differences between racial groups. We did, however, observe two patterns in that data that are worthy of discussion. First, because participants were from the south, the finding that participants from both racial groups ascribe to a religious belief system to make sense of their lived experiences is not surprising. Rather, it appears to be reflective of the religious culture that is an integral part of the south and our identity as a nation. A second noteworthy finding is that while a significant number of participants believe that a relationship exists between health status, genes, and religious behaviors, they also recognize that positive health behaviors must also be adopted as a means for staving off disease. In some cases, however, there was a belief that health issues could dissolve or disappear as a result of certain religious behaviors such as prayer. © 2009 Wiley‐Liss, Inc.
The role and impact of personal faith and religion among genetic service providers
Authors: Geller Gail , Micco Ellyn , Silver Rachel J. , Kolodner Ken , Bernhardt Barbara A. 
Published: January 2009

AbstractThis paper describes the impact of genetic service providers' personal faith and religious values on their experiences interacting with colleagues and patients. We surveyed 480 clinical geneticists (MDs), genetic counselors (GCs), and genetic nurses randomly selected from their professional associations, and then interviewed a sample of survey respondents. Outcomes included religiosity, coping with distress through spiritual beliefs, and personal value conflicts (PVCs). Two hundred fourteen providers completed the survey out of an estimated 348 eligible (61% response rate). Importance attributed to regular attendance at religious services ranged from 39% (not at all important) to 27% (very important). Reliance on religion and spiritual beliefs as a source of comfort ranged from 48% (never) to 33% (sometimes or often). Religiosity varied by discipline with 58% of nurses thinking regular attendance at religious services was moderately or very important as compared to 47% of GCs and 30% of MDs (P = 0.006). Ten percent of respondents had difficulty reconciling their own faith with being a genetics professional, 14% felt the need to hide their own faith from their colleagues or patients, 7% thought their professional stance was not consistent with their personal values, and 4% felt ostracized by the genetics community because of their personal beliefs. The experience of such PVCs was positively correlated with religiosity (r = 0.35; P < 0.0001). GCs were more likely to experience PVCs than MDs or nurses (P = 0.013). Data from the interviews (N = 54) support these findings. A significant minority of genetic service providers are religiously observant and rely on their religious values to cope with distress. These individuals often experience difficulty reconciling their religious beliefs with the expectations of their profession, and sharing their beliefs with their colleagues and patients. Efforts should be made to prevent or reduce the secrecy surrounding personal faith and religion among genetics professionals. © 2009 Wiley‐Liss, Inc.
God and genes in the caring professions: Clinician and clergy perceptions of religion and genetics
Authors: Bartlett Virginia L. , Johnson Rolanda L. 
Published: January 2009

AbstractLittle is known about how care providers' perceptions of religion and genetics affect interactions with patients/parishioners. This study investigates clinicians' and clergy's perceptions of and experiences with religion and genetics in their clinical and pastoral interactions. This is an exploratory qualitative study designed to elicit care providers' descriptions of experiences with religion and genetics in clinical or pastoral interactions. Thirteen focus groups were conducted with members of the caring professions: physicians, nurses, and genetics counselors (clinicians), ministers and chaplains (clergy). Preliminary analysis of qualitative data is presented here. Preliminary analysis highlights four positions in professional perceptions of the relationship between science and faith. Further, differences among professional perceptions appear to influence perceptions of needed or available resources for interactions with religion and genetics. Clinicians' and clergy's perceptions of how religion and genetics relate are not defined solely by professional affiliation. These non‐role‐defined perceptions may affect clinical and pastoral interactions, especially regarding resources for patients and parishioners. © 2009 Wiley‐Liss, Inc.
Moving up the slippery slope: Mandated genetic screening on Cyprus
Authors: Cowan Ruth Schwartz 
Published: January 2009

AbstractMany social scientists and bioethicists have argued that genetic screening is a new form of eugenics. Examination of the development of the quasi‐mandated screening program for β‐thalassemia in the Republic of Cyprus (1970–1984) demonstrates that there is nothing eugenic about modern genetic screening practices. The Cypriot screening program involves mandated premarital carrier screening, voluntary prenatal diagnosis (originally through fetoscopy, now through CVS), and voluntary termination of afflicted pregnancies—all at public expense. In the Republic of Cyprus, the mandating agency for genetic screening is the established church, so this examination also demonstrates that religious authorities with profound objections to abortion can balance that moral precept against others, such as the imperative to reduce suffering that sometimes conflict with it. © 2009 Wiley‐Liss, Inc.
Manual digital pressures during knuckle‐walking in chimpanzees (Pan troglodytes)
Authors: Wunderlich R.E. , Jungers W.L. 
Published: January 2009

AbstractConsiderable attention has been given to hand morphology and function associated with knuckle‐walking in the African apes because of the implications they have for the evolution of bipedalism in early hominins. Knuckle‐walking is associated with a unique suite of musculoskeletal features of the wrist and hand, and numerous studies have hypothesized that these anatomical features are associated with the dynamics of load distribution across the digits during knuckle‐walking. We collected dynamic digital pressures on two chimpanzees during terrestrial and simulated arboreal locomotion. Comparisons were made across substrates, limb positions, hand positions, and age categories. Peak digital pressures were similar on the pole and on the ground but were distributed differently across the digits on each substrate. In young animals, pressure was equally high on digits 2–4 on the ground but higher on digits 3 and 4 on the pole. Older animals experience higher pressures on digits 2 and 3 on the ground. Hand posture (palm‐in vs. palm‐back) influenced the distribution and timing of peak pressures. Age‐related increases in body mass also result in higher overall pressures and increased variation across the digital row. In chimpanzees, digit 5 typically bears relatively little load regardless of hand position or substrate. These are the first quantitative data on digital pressures during knuckle‐walking in hominoids, and they afford the opportunity to develop hypotheses about variation among hominoids and biomechanical models of wrist and forearm loading. Am J Phys Anthropol 2009. © 2009 Wiley‐Liss, Inc.