bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Application of Nanomaterials for the Rescue of a Single Compromised Tooth with a Multidisciplinary Approach: Case Report and Scoping Review
Authors: Aiuto Riccardo , Villani Federico Alcide , Lipani Erica , Kara Aysenur , Garcovich Daniele , Dioguardi Mario , Carli Elisabetta , Re Dino 
Published: April 2024

Background
A nanomaterial is defined as an insoluble or biopersistent and intentionally manufactured material with one or more external dimensions, or an internal structure on the scale from 1 nm to 100 nm. They are commonly considered as those materials in which the shape and molecular composition at a nanometer scale can be controlled. This extension of nanotechnology in the field of dentistry is termed “Nanodentistry”, and it has expanded to every single branch of dentistry, such as restorative, endodontic, prosthetic, and periodontology.

Case Report
The principal aim of the study was to report a noteworthy case of a 35-year-old male whose central incisor with Class III Heithersay EICR (external invasive cervical resorption) was managed through a multidisciplinary approach and the employment of various nanomaterials. Furthermore, a narrative review was also performed to investigate the state of the art of nanomaterials in different fields of modern dentistry, analyzing their application and characteristics for the recovery of a single compromised tooth. The primary sources were selected through the use of search engines, such as Pubmed (Medline), EBSCO, and Cochrane Library.

Results
Using the MeSH and non-MeSH terms and applying the search strategy previously described, a total of 442 articles were selected through search engines, such as Pubmed (Medline), EBSCO, and Cochrane Library. Titles and abstracts were screened and then full texts of all potentially relevant publications were obtained and reviewed independently. Through the application of inclusion and exclusion criteria, a total of 20 articles were selected.

Conclusion
The present case report, as well as the review of the literature, emphasize that nowadays, the adhesive systems available allow a minimally invasive treatment, which also ensures excellent aesthetic and functional results avoiding the loss of a tooth with a high aesthetic value. Interactions between different biomaterials and nanoparticles (bioceramics, sealers, nanocomposites, radicular dentin, and adhesive cementation) and correct tissue response have been reported. Further studies are needed on the topic.
In silico Characterization of an Initiation Factor 2 Kinase of Black Fungi:
A Potential Drug Target for Mycosis
Authors: Assunção Cláudia Barbosa , de Aguiar Edgar Lacerda , Chávez-Fumagalli Miguel A. , La Santrer Emanuelle Rutren , Dias Sandro Renato , de Souza Rodrigues Thiago , Caligiorne Rachel Basques 
Published: April 2024

:
Fungi infections are responsible for more than 1.6 million deaths per year worldwide.
Treatment is time-consuming, compromising the kidney and liver functions. in silico analyses
have facilitated the discovery of new drugs that may present fewer side effects. In this connection,
kinases that phosphorylate the translation initiation factor eIF-2 are candidate proteins for potent
new drugs, which have been recognized as important in maintaining protein synthesis. Substances
that interfere with the phosphorylation of the eIF2α factor may be the way to inhibit the production
of proteins and accelerate the fungi's death. To determine whether this enzyme can be used as
a new drug target, this study aimed to perform in silico functional annotation and characterization
of eIF2 factor kinase´s three-dimensional structure from three species of black fungi. In addition,
inhibitors that could interact and bind to the active site of the enzyme were explored. The hypothetical
protein was submitted to the databases and bioinformatics tools for its characterization, whose
analysis of protein-protein interactions was modeled and inhibitors anchored. Protein interaction
analysis linked the kinases with other molecules in protein translation and ribosome recycling.
However, centrality analysis showed only one kinase as a possible drug target. The inhibitors
showed coupling with the active site of protein kinases, and these results indicate a possible blockade
of the enzymatic function that can accelerate the response to the drugs. This study demonstrates
that biochemical characterization and in silico validation studies of potential drugs can be
more efficient and yield faster results.
Peptide Drugs: Current Status and it's Applications in the Treatment of
Various Diseases
Authors: Chandarana Chandni , Juwarwala Isha , Shetty Shravi , Bose Anushree 
Published: April 2024

Abstract:
Peptides represent a class of natural molecules with diverse physiological functions, including
hormone regulation, neurotransmission, and immune modulation. In recent years, peptide-
based therapeutics have gained significant attention in pharmaceutical research and development
due to their high specificity, efficacy, and relatively low toxicity. This review provides an
overview of the current landscape of peptide drug development, highlighting the challenges faced
in their formulation and delivery and the innovative strategies employed to overcome these hurdles.
The review explores the wide range of applications of peptide drugs in treating various diseases,
including HIV, multiple sclerosis, osteoporosis, chronic pain, diabetes, and cancer. Examples
of FDA-approved peptide drugs and ongoing clinical trials are presented, showcasing the
continuous advancements in peptide-based therapeutics across different therapeutic areas. This review
underscores the promising potential of peptide drugs as targeted and effective treatments for
a multitude of medical conditions, offering improved therapeutic outcomes and enhanced patient
care.
Comparison of the Neutralization Power of Sotrovimab Against SARS-CoV-2 Variants: Development of a Rapid Computational Method
Authors: Ashoor Dana , Marzouq Maryam , Fathallah M-Dahmani 
Published: April 2024

Background
The rapid evolution of SARS-CoV-2 imposed a huge challenge on disease control. Immune evasion caused by genetic variations of the SARS-CoV-2 spike protein’s immunogenic epitopes affects the efficiency of monoclonal antibody–based therapy of COVID-19. Therefore, a rapid method is needed to evaluate the efficacy of the available monoclonal antibodies against the new emerging variants or potential novel variants.

Objective
The aim of this study is to develop a rapid computational method to evaluate the neutralization power of anti–SARS-CoV-2 monoclonal antibodies against new SARS-CoV-2 variants and other potential new mutations.

Methods
The amino acid sequence of the extracellular domain of the spike proteins of the severe acute respiratory syndrome coronavirus (GenBank accession number YP_009825051.1) and SARS-CoV-2 (GenBank accession number YP_009724390.1) were used to create computational 3D models for the native spike proteins. Specific mutations were introduced to the curated sequence to generate the different variant spike models. The neutralization potential of sotrovimab (S309) against these variants was evaluated based on its molecular interactions and Gibbs free energy in comparison to a reference model after molecular replacement of the reference receptor-binding domain with the variant’s receptor-binding domain.

Results
Our results show a loss in the binding affinity of the neutralizing antibody S309 with both SARS-CoV and SARS-CoV-2. The binding affinity of S309 was greater to the Alpha, Beta, Gamma, and Kappa variants than to the original Wuhan strain of SARS-CoV-2. However, S309 showed a substantially decreased binding affinity to the Delta and Omicron variants. Based on the mutational profile of Omicron subvariants, our data describe the effect of the G339H and G339D mutations and their role in escaping antibody neutralization, which is in line with published clinical reports.

Conclusions
This method is rapid, applicable, and of interest to adapt the use of therapeutic antibodies to the treatment of emerging variants. It could be applied to antibody-based treatment of other viral infections.
Optimized treatment of elderly patients with type 2 diabetes mellitus and hypertension in general practice
Authors: Kazakov Yu.M. , Muravlova O.V. , Nastroga T.V. , Kitura O.E. , Shut S.V. 
Published: April 2024

Background. Population aging has become a leading demographic feature of Ukraine. According to the World Health Organization, the number of elderly and senile people will increase to almost 40 % in the coming decades. Hypertension and type 2 diabetes mellitus (DM) are among the leading factors of cardiovascular risk. It is known that excessive oxidant stress and low-grade subclinical chronic systemic inflammation are determining factors of endothelial dysfunction, vascular reactivity disorders, increased peripheral vascular resistance, carbohydrate, and lipid metabolism disorders, which leads to increased blood pressure and plasma glucose levels. Hypertension and type 2 DM are among the leading cardiovascular risk factors. The purpose of the study was to increase the effectiveness of treatment and improve the quality of life of elderly patients with combined pathology of hypertension and type 2 DM by additional inclusion of empagliflozin and L-arginine in the basic therapy. Materials and methods. Fifty elderly patients with comorbid pathology were under our observation for second stage hypertension, coronary heart disease (functional class II) and type 2 DM in the stage of subcompensation. Participants were divided into two groups: the first one, controls (n = 25), received generally accepted basic therapy. In the second group (n = 25), the following drugs were added to the basic therapy: empagliflozin 10 mg/day, L-arginine 300 mg/day. Results. Clinical observation in outpatient conditions lasted for 3 months. Comprehensive therapy in the elderly patients with comorbid pathology of hypertension and type 2 diabetes, with the additional inclusion of empagliflozin and L-arginine to the basic therapy, contributes to a significant positive effect on the clinical course, reduces the risk of progression of this constellation. Conclusions. The application of the proposed comprehensive therapy in outpatient conditions under the control of a family doctor will significantly improve the quality of life of patients and prevent the development of complications
Simulating aerosol-radiation effects on subseasonal prediction using the coupled Unified Forecast System and CCPP-Chem: prescribed aerosol climatology versus interactive aerosol model
Authors: Sun Shan , Grell Georg A. A. , Zhang Li (Kate) , Wang Siyuan , Heinzeller Dominikus , Li Haiqin , Meixner Jessica , Bhattacharjee Partha Sarathi , Henderson Judy 
Published: April 2024

This study investigates the effects of aerosol-radiation interaction on
subseasonal prediction using the Unified Forecast System (UFS) with an
ocean, a sea ice and a wave component, coupled to an aerosol component.
The aerosol component is from the current NOAA operational
GEFSv12-Aerosols model, which includes the GOCART aerosol modules
simulating sulfate, dust, black carbon, organic carbon, and sea-salt.
The modeled aerosol optical depth (AOD) is compared to reanalysis from
Modern-Era Retrospective analysis for Research and Applications, Version
2 (MERRA2) and observations from Moderate Resolution Imaging
Spectro-radiometer (MODIS) satellite andAtmospheric Tomography (ATom)
aircraft. Despite biases primarily in dust and sea salt, a good
agreement in AOD is achieved globally. The simulated radiative forcing
(RF) from the total aerosols at the top of the atmosphere is
approximately -2.5 W/m2 or -16 W/m2 per unit AOD globally. This is
consistent with previous studies.
In subsequent simulations, prognostic aerosol component is substituted
with climatological aerosol concentrations derived from initial
experiments. While regional differences in RF are noticeable in specific
events between these two experiments, the resulting RF, surface
temperature, geopotential height at 500 hPa and precipitation, show
similarities in multi-year subseasonal applications. This suggests that
given the current capacities of the aerosol modeling, adopting a
climatology of aerosol concentrations as a cost-effective substitute for
the intricate aerosol module may be a practical approach for subseasonal
applications.
PENGGUNAAN STRATEGI METAKOGNITIF MAHASISWA PROGRAM STUDI PENDIDIKAN BAHASA JEPANG FKIP UNIVERSITAS RIAU
Authors: Pratiwi Novia , Rahayu Nana , Budiani Dini 
Published: April 2024

Strategi metakognitif merupakan salah satu strategi belajar bahasa yang digunakan oleh pembelajar bahasa asing yang berhubungan dengan fokus pada pembelajaran, perencanaan dan evaluasi. Tujuan penelitian ini untuk mengetahui bagaimana penggunaan strategi metakognitif mahasiswa program studi pendidikan bahasa Jepang FKIP Universitas Riau. Metode pada penelitian ini adalah deskriptif kuantitatif. Instrumen dalam penelitian menggunakan angket tertutup dengan skala Likert. Teknik analisis data menggunakan analisis statistik deskriptif. Hasil data deskriptif kuantitatif menunjukkan bahwa semua indikator strategi metakognitif termasuk kategori tinggi. Pada indikator fokus pembelajaran didapatkan hasil dengan nilai rata-rata (3.51); indikator perencanaan (3.51) dan pada indikator evaluasi (3.57). Berdasarkan hasil penelitian, penggunaan strategi metakognitif mahasiswa pendidikan bahasa Jepang berada dalam kategori tinggi untuk semua indikator strategi metakognitif, yaitu fokus pada pembelajaran, perencanaan dan evaluasi. Hal ini menunjukkan bahwa penggunaan strategi metakognitif digunakan secara merata oleh mahasiswa pendidikan bahasa Jepang FKIP Universitas Riau.
PROSES PENYERAPAN GAIRAIGO DALAM BAHASA JEPANG PADA SITUS WEB RESTORAN & BAR DI OKINAWA MARRIOTT RESORT & SPA: SEBUAH TINJAUAN MORFOLOGI
Authors: Surya I Gede , Suartini Ni Nengah , Hermawan Gede Satya 
Published: April 2024

ABSTRAK Penelitian ini bertujuan untuk mendeskripsikan proses penyerapan gairaigo pada situs web resmi restoran & bar Okinawa Marriott Resort & Spa periode bulan Mei-Juli tahun 2020. Ini merupakan penelitian deskriptif kualitatif. Teori yang digunakan untuk menganalisis adalah teori morfologi dan teori proses penyerapan gairaigo. Metode pengumpulan data yang digunakan adalah metode simak dengan teknik catat. Data dianalisis dengan metode deskriptif. Hasil penelitian ini menunjukkan bahwa pada proses penyerapan gairaigo terdapat dua proses yaitu; proses adaptasi dan kreasi. Secara morfologis proses adaptasi gairaigo dilakukan dengan afiksasi yang ditemukan pada kelas kata verba, adjektiva, dan advervia. Sedangkan afiksasi tidak terjadi pada kelas kata nomina. Sementara secara morfologis penyerapan gairaigo dengan cara kreasi dilakukan dengan komposisi atau penggabungan kata gairaigo dengan wago dan kango yang menghasilkan kosakata wasei-gairaigo, wasei-eigo dan konshugo. 要旨 本研究は沖縄マリオットレゾート＆スパのウェブサイト2020年５月号から７月号までのレストラン・バーサイトに使用されている外来語の語形の日本語化の解明である。形態論と外来語の語形の日本語化論を用い。定性的記述研究である。データは記述的方法で分析される。結果、外来語の日本語化には二つのプロセスがあることを示している。 適応と作成のプロセスである。 形態学的には、外来語の適応プロセスは、動詞、形容詞、副詞に見られる接辞によって行われる。名詞では接辞はない。形態学的には、作成プロセスによる外来語の日本語化は、外来語と和語や漢語を組み合わせて、和製外来語、和製英語、混種語の語彙を生成することがわかった。
KONTRIBUSI NORMATIF ABU HANIFAH DALAM PENENTUAN AWAL BULAN KAMARIAH
Authors: Fatmawati Emyllia , Syarif Rasdiyanah Audiah 
Published: April 2024

This research is seen from Muslims who are faced with the problem of determining the beginning of the month of Kamariyah, but they still have not found a common point, as is the difference in the opinions of the scholars of the four schools regarding the determination of the beginning of the month of Kamariyah. In Islam, the determination of the beginning of the lunar month begins with the sight of the new moon, which is part of ijtihad. Abu Hanifah is one of the imam of the madzab who made a valuable contribution to the development of Islamic law. His Ijtihad about fulfilling 30 days when cloudy in determining the beginning of the month of kamariyah has been used by the followers of this madzab, which is only 30% in the world such as in India and Pakistan and Afghanistan. The purpose of this research is to study the method used by Imam Hanafi, one of the four Imam Madzab in determining the beginning of the month of the month.
KALENDER HIJRIAH KRITERIA 29 DALAM TINJAUAN FIKIH
Authors: Elly Uzlifah  
Published: April 2024

Kalender Hijriah kriteria 29 gagasan Hendro Setyanto merupakan sebuah cara pandang baru dalam penyusunan dan penyatuan kalender Hijriah di Indonesia yang masih begitu kental perbedaan antara corak pemahaman mażhab hisab dan mażhab rukyah. Jika kriteria yang ada selama ini mencoba melakukan pendekatan awal bulan dengan kriteria visibilitas hilal yang kondisi visibilitasnya sangat bergantung terhadap kondisi lokal, maka kriteria 29 hadir dengan pendekatan iklim tropis khas Indonesia, karena upaya untuk menerapkan kriteria visibilitas suatu tempat ke tempat lain tentu memiliki ragam masalah dan kendala yang berbeda-beda. Perhitungan mundur kalender Hijriah kriteria 29 secara Astronomis merupakan hisab murni yang bersifat argumentatif dengan perhitungan akurasi tinggi (high accuracy computing method). Hasil penelitian menunjukkan bahwa secara Fikih, kosep dasar kalender Hijriah kriteria 29 dalam penentuan awal bulan kamariah sesuai dengan pandangan jumhur ulama fikih, namun betapapun hisab kalender Hijriah kriteria 29 mendapat posisi yang wajar, rukyah tetap dinyatakan sebagai patokan (al-aṣl).

Kata Kunci : Kalender Hijriah Kriteria 29, Fikih
PROBLEMATIKA BENTUK BUMI DALAM PERSPEKTIF FIQH DAN SAINS
Authors: Fathurrahman  , Irfan  
Published: April 2024

Pandangan bahwa Bumi itu datar berawal dari peradaban kuno dunia, seperti Mesir, Babilonia, Mesapotamia, China, dan India. dan bertahan sampai era Aristoteles. Paham ini kembali berkembang pada abad ke 18 oleh seorang Inggris bernama Samuel Rowbotham yang terinspirasi dari ayat Alkitab. di Indonesia paham Bumi datar mulai ramai didebatkan pada tahun 2017 saat laman Youtube Flat Earth 101 viral. Masalah perdebatan bentuk Bumi juga merambah hingga aspek agama. Sebagian besar ulama sepakat bahwa Bumi berbentuk bola dan sebagian lainnya menganggap bahwa Bumi ini datar, namun persoalan bentuk Bumi ini bukanlah bentuk aqidah. Sementara praktik ibadah umat Islam banyak ditentukan menggunakan perhitungan model astronomi Bumi bulat. Sejumlah pengamatan benda langit sebenarnya secara empirik membuktikan Bumi bulat namun beberapa golongan orang tidak mempercayainya.
Kata kunci: Bumi Bulat, Datar, Astronomi
KALENDER ROWOT SASAK
Authors: Awaludin Muhammad , Sado Arino Bemi , Muhammad Haikal Rivaldi  
Published: April 2024

Indonesia, has two calendars that have been strongly attached to the way of life in its society. These are the Gregorian calendar and the Hijri calendar. In addition, each region of Indonesia also has its own traditional calendar system. One type of traditional calendar that is still alive today is the Rowot Sasak Calendar. The Rowot Sasak Calendar uses the Moon as the base for its calculation system, so it is very similar to the Hijriyah system. But as a traditional calendar, the cultural components in it are very similar to the Islamic Javanese Calendar. So the author is interested in further research on the existence of cultural acculturation between Islam, Java and Sasak in the Rowot Sasak Calendar. This research uses qualitative methodology with field study research type and descriptive qualitative analysis. The findings of this study indicate that there is a strong acculturation between the three cultures in the rowot sasak calendar. The acculturation is based on the system that uses the Islamic calendar (Hijriyah) urfi hisab system. This is proven by the names of the months that adopt from the Hijriyah calendar, as well as the number of days 29/30 each month. Meanwhile, the Javanese cultural element can be identified in the component of determining good days for the community. In addition, the use of market names such as kliwon, wage, pahing, pon and legi is strong evidence of Javanese cultural acculturation. While the elements of Sasak culture itself can be found in the mention of the name of the day and other cultural terms that use terms in the Sasak language. As well as the determination of mangse (season) which uses the 5-15-25 tradition benchmark with synchronization on the Hijriyah calendar.
IMPLEMENTASI PENANGGALAN DAYAK WEHEA DALAM KEGIATAN ADAT DI KAMPUNG DAYAK MUARA WAHAU
Authors: Nur Robaniyah  , Nur Azizah Maulidatun 
Published: April 2024

The Wehea Dayak is one of the Dayak tribes that still exist today. The Wehea Dayak tribe lives in close proximity to nature. They depend on the surrounding rivers, mountains, and forests. Daily activities cannot be separated from farming and hunting. This activity has a close relationship with the Dayak Wehea traditional activities. In determining the time of traditional activities, the Wehea Dayak people still use the Wehea Dayak calendar, which is a legacy from their previous ancestors. The Dayak Wehea calendar is unique among most calendars in Indonesia. The Wehea Dayak calendar only has two elements, namely the 29/30 months and the 10 periods. The Wehea Dayak calendar does not recognize years like other calendars. This research examines how the Dayak Wehea calendar is implemented in the traditional activities and rituals of the Dayak Wehea community in Muara Wahau District. This research is field research conducted in Muara Wahau District in August and December 2017. This research uses a qualitative approach to describe the research results. The results of this research explain that the Wehea Dayak people use this calendar for ten periods, which refers to traditional activities. This implementation includes determining the cutting period (Nep bloh), farming time (Nemeq), time to plant rice (Nugal), rituals in the fields (Entaglel), the ritual of welcoming the rice that begins to contain (Embeq Hemin Plai), harvest time (Neljiang), the period of completion of harvest (Mel Haq Pangseh May), rice feast (Erau/Lom Plai), time to make a hut (Naq Jengea), and finally the children's era/wedding party (Nak Lom).
Postprandial effects following a semielemental critical-care diet lead to changes in uric acid, bile acids, and glucose in the central bearded dragon (Pogona vitticeps)
Authors: Cusack Lara M. , Comolli Jessica R. , Divers Stephen J. 
Published: April 2024

Abstract

OBJECTIVE
To assess the prandial effects of a semielemental diet on plasma uric acid, bile acid, and glucose concentrations in the central bearded dragon (Pogona vitticeps).

ANIMALS
13 healthy adult male bearded dragons.

METHODS
Following a 72-hour fasting period, blood was collected to measure preprandial uric acid, bile acid, and glucose concentrations. The animals were then gavage fed 1.2% body weight of an omnivore critical-care diet containing 20% protein, 9.5% fat, 2.5% fiber, and 2.39 kcal/mL. Blood was collected for repeat concentrations at 4 and 24 hours.

RESULTS
Median (IQR) uric acid concentration (mg/dL) increased from 3.8 preprandial (2.8 to 4.3) to 4.7 4 hours postprandial (4 to 7; P = .0001). Median (IQR) bile acid concentration (mg/dL) increased from 1.8 preprandial (1 to 3.4) to 9.5 24 hours postprandial (5.6 to 10.4; P = .004). Median (IQR) glucose concentration (mg/dL) was 209 at time 0 (193 to 216), 287 at 4 hours (258 to 312), and 393 at 24 hours (361 to 464). Significant increases were seen between pre- and 4-hours-postprandial (P < .0001), pre- and 24-hours-postprandial (P < .0001), and 4-hours- and 24-hours-postprandial (P < .0001) glucose concentrations.

CLINICAL RELEVANCE
Results suggest that postprandial status and diet composition should be considered during the interpretation of some biochemical analytes in the bearded dragon.