bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of sitting at work on musculoskeletal complaints of German workers - results from the study on mental health at work (S-MGA)
Authors: Dang T. H. An , Starke Karla Romero , Liebers Falk , Burr Hermann , Seidler Andreas , Hegewald Janice 
Published: March 2024

Abstract
Introduction
Sedentary behavior (including prolonged sitting) is a form of physical inactivity that has a negative impact on health, possibly including musculoskeletal complaints (MSCs). The purpose of this study was to determine the extent to which time spent sitting at work is associated with the one-year prevalence of MSCs in the neck, shoulder, upper back/thoracic spine, and lower back among workers from the Study of Mental Health in the Workplace (S-MGA). In addition, the study also examined whether leisure time, physical activity, and sex modify the relationship between occupational sitting and MSCs.

Methods
For this analysis, we used the S-MGA, a 5-year prospective study in Germany. The S-MGA is a nationwide representative employee cohort study with a baseline survey in 2012 and a follow-up survey in 2017. Sitting at work was measured using a question asked at baseline. The Nordic Musculoskeletal Questionnaire was used to determine the one-year prevalence of MSCs in the neck, shoulder, upper back, and lower back pain (yes/no). The assessment of MSCs was only conducted at the 2017 follow-up. Adjusted Poisson regression models were used to determine the association of baseline level of weekly hours spent sitting at work with MSCs during follow-up. In addition to unadjusted models, models were adjusted for demographic (age, sex, body mass index and occupational skill level), occupational (heavy lifting at work), psychological disorders and lifestyle factors (smoking status and leisure time physical activity), as well as preexisting musculoskeletal conditions reported at baseline. To examine whether the relationship between sitting time and pain was modified by sex and leisure time physical activity, the models were stratified for both these variables.

Results
Among the participants analyzed (n = 2,082), 49.8% were male, while 50.2% were female, and more than 60% of the study population spent over half of their working hours in a sitting position. Exposure to increased sitting at work reported at baseline was not consistently associated with 12-month prevalence of MSCs in the upper body at follow-up. However, differences in the association between occupational sitting and MSCs were dependent on the intensity of leisure time physical activity. Prevalence ratios (PRs) indicated an increased prevalence of MSC in the neck (PR = 1.46; 95% CI = 1.18–1.80) and shoulder (PR = 1.30; 95% CI = 1.03–1.64) in workers without leisure time physical activity who spent 25 to < 35 weekly working hours sitting.

Discussion
These findings suggest that leisure time physical activity interacts with the relationship between sitting at work and MSCs. The relationship between sitting at work and musculoskeletal pain needs further investigation, but we found indications that leisure time physical activity may counter the effects of sitting at work.
HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases
Authors: Calliari Anna , Daughrity Lillian M. , Albagli Ellen A. , Castellanos Otero Paula , Yue Mei , Jansen-West Karen , Islam Naeyma N. , Caulfield Thomas , Rawlinson Bailey , DeTure Michael , Cook Casey , Graff-Radford Neill R. , Day Gregory S. , Boeve Bradley F. , Knopman David S. , Petersen Ronald C. , Josephs Keith A. , Oskarsson Björn , Gitler Aaron D. , Dickson Dennis W. , Gendron Tania F. , Prudencio Mercedes , Ward Michael E. , Zhang Yong-Jie , Petrucelli Leonard 
Published: March 2024

AbstractThis letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases.
Role of polyphenols in remodeling the host gut microbiota in polycystic ovary syndrome
Authors: Zhou Ping , Feng Penghui , Liao Baoying , Fu Lin , Shan Hongying , Cao Canhui , Luo Renxin , Peng Tianliu , Liu Fenting , Li Rong 
Published: March 2024

AbstractPolycystic ovary syndrome (PCOS) is a common reproductive and metabolic condition in women of childbearing age and a major cause of anovulatory infertility. The pathophysiology of PCOS is complex. Recent studies have reported that apart from hyperandrogenism, insulin resistance, systemic chronic inflammation, and ovarian dysfunction, gut microbiota dysbiosis is also involved in PCOS development and may aggravate inflammation and metabolic dysfunction, forming a vicious cycle. As naturally occurring plant secondary metabolites, polyphenols have been demonstrated to have anticancer, antibacterial, vasodilator, and analgesic properties, mechanistically creating putative bioactive, low-molecular-weight metabolites in the human gut. Here, we summarize the role of gut microbiota dysbiosis in the development of PCOS and demonstrate the ability of different polyphenols - including anthocyanin, catechins, and resveratrol - to regulate gut microbes and alleviate chronic inflammation, thus providing new insights that may assist in the development of novel therapeutic strategies to treat women with PCOS.
Unraveling the role of HIF-1α in sepsis: from pathophysiology to potential therapeutics—a narrative review
Authors: Ruan Hang , Zhang Qin , Zhang You-ping , Li Shu-sheng , Ran Xiao 
Published: March 2024

AbstractSepsis is characterized by organ dysfunction resulting from a dysregulated inflammatory response triggered by infection, involving multifactorial and intricate molecular mechanisms. Hypoxia-inducible factor-1α (HIF-1α), a notable transcription factor, assumes a pivotal role in the onset and progression of sepsis. This review aims to furnish a comprehensive overview of HIF-1α's mechanism of action in sepsis, scrutinizing its involvement in inflammatory regulation, hypoxia adaptation, immune response, and organ dysfunction. The review encompasses an analysis of the structural features, regulatory activation, and downstream signaling pathways of HIF-1α, alongside its mechanism of action in the pathophysiological processes of sepsis. Furthermore, it will delve into the roles of HIF-1α in modulating the inflammatory response, including its association with inflammatory mediators, immune cell activation, and vasodilation. Additionally, attention will be directed toward the regulatory function of HIF-1α in hypoxic environments and its linkage with intracellular signaling, oxidative stress, and mitochondrial damage. Finally, the potential therapeutic value of HIF-1α as a targeted therapy and its significance in the clinical management of sepsis will be discussed, aiming to serve as a significant reference for an in-depth understanding of sepsis pathogenesis and potential therapeutic targets, as well as to establish a theoretical foundation for clinical applications.
Graphical Abstract
Systematic immune cell dysregulation and molecular subtypes revealed by single-cell RNA-seq of subjects with type 1 diabetes
Authors: Honardoost Mohammad Amin , Adinatha Andreas , Schmidt Florian , Ranjan Bobby , Ghaeidamini Maryam , Arul Rayan Nirmala , Gek Liang Lim Michelle , Joanito Ignasius , Xiao Xuan Lin Quy , Rajagopalan Deepa , Qi Mok Shi , Hwang You Yi , Larbi Anis , Khor Chiea Chuen , Foo Roger , Boehm Bernhard Otto , Prabhakar Shyam 
Published: March 2024

Abstract
Background
Type 1 diabetes mellitus (T1DM) is a prototypic endocrine autoimmune disease resulting from an immune-mediated destruction of pancreatic insulin-secreting $$\beta$$
β
cells. A comprehensive immune cell phenotype evaluation in T1DM has not been performed thus far at the single-cell level.

Methods
In this cross-sectional analysis, we generated a single-cell transcriptomic dataset of peripheral blood mononuclear cells (PBMCs) from 46 manifest T1DM (stage 3) cases and 31 matched controls.

Results
We surprisingly detected profound alterations in circulatory immune cells (1784 dysregulated genes in 13 immune cell types), far exceeding the count in the comparator systemic autoimmune disease SLE. Genes upregulated in T1DM were involved in WNT signaling, interferon signaling and migration of T/NK cells, antigen presentation by B cells, and monocyte activation. A significant fraction of these differentially expressed genes were also altered in T1DM pancreatic islets. We used the single-cell data to construct a T1DM metagene z-score (TMZ score) that distinguished cases and controls and classified patients into molecular subtypes. This score correlated with known prognostic immune markers of T1DM, as well as with drug response in clinical trials.

Conclusions
Our study reveals a surprisingly strong systemic dimension at the level of immune cell network in T1DM, defines disease-relevant molecular subtypes, and has the potential to guide non-invasive test development and patient stratification.
Donepezil-induced bradycardia in a schizophrenic patient with comorbid neurocognitive disorder: a case report and review of the literature
Authors: Odenigbo Nkolika , Nkemjika Stanley , Atolagbe Ayodele , Nwabueze Christian , Olwit Connie , Lawrence Jeffery , Olupona Tolulope 
Published: March 2024

Abstract
Background
Trials of cholinergic and glutamatergic agents have improved cognition and memory for the geriatric schizophrenic population. Donepezil is an acetylcholinesterase inhibitor that improves cognition by preventing postsynaptic degradation of hippocampal acetylcholine in patients with mild-to-moderate dementia. Donepezil has been attributed to some adverse effects, especially gastrointestinal symptoms. However, cardiovascular adverse effects are not common as there remains a dearth of literature regarding donepezil-induced bradycardia.

Case report
Hence, we present the case of a 70-year-old Hispanic female with past psychiatry history of schizophrenia who developed bradycardia and syncope following the commencement of low-dose donepezil in the inpatient unit and subsequent resolution with cessation. She had no prior cardiovascular symptoms or diagnosis.

Discussion
Considering there is no baseline cardiac monitoring requirement guideline for patients on Donepezil treatment, pre-assessment electrocardiogram is advised before the commencement of acetylcholinesterase inhibitors. Finally, routine monitoring of vital signs for at least the first 72 hours following the start of donepezil might be good proactive practice for all psychiatrists. Extending this practice to inpatient and outpatient service settings will be worthwhile.
Gut barrier dysfunction and the risk of ICU-acquired bacteremia- a case–control study
Authors: Varkila Meri R. J. , Verboom Diana M. , Derde Lennie P. G. , van der Poll Tom , Bonten Marc J. M. , Cremer Olaf L. ,   the MARS consortium, de Beer Friso M. , Bos Lieuwe D. J. , Glas Gerie J. , Hoogendijk Arie J. , van Hooijdonk Roosmarijn T. M. , Horn Janneke , Huson Mischa A. , Juffermans Nicole P. , Schouten Laura R. A. , Scicluna Brendon , Schultz Marcus J. , Straat Marleen , van Vught Lonneke A. , Wieske Luuk , Wiewel Maryse A. , Witteveen Esther , Bonten Marc J. M. , Cremer Olaf L. , Frencken Jos F. , van de Groep Kirsten , Klouwenberg Peter M. C. Klein , Koster-Brouwer Maria E. , Ong David S. Y. , Varkila Meri R. J. , Verboom Diana M. 
Published: March 2024

Abstract
Background
Impaired intestinal barrier function can enable passage of enteric microorganisms into the bloodstream and lead to nosocomial bloodstream infections during critical illness. We aimed to determine the relative importance of gut translocation as a source for ICU-acquired enterococcal bacteremia of unknown origin.

Methods
We conducted a nested case–control study in two mixed medical-surgical tertiary ICUs in the Netherlands among patients enrolled between 2011 and 2018. We selected 72 cases with ICU-acquired bacteremia due to enterococci (which are known gastrointestinal tract commensals) and 137 matched controls with bacteremia due to coagulase-negative staphylococci (CoNS) (which are of non-intestinal origin). We measured intestinal fatty acid-binding protein, trefoil factor-3, and citrulline 48 h before bacteremia onset. A composite measure for Gut Barrier Injury (GBI) was calculated as the sum of standardized z-scores for each biomarker plus a clinical gastrointestinal failure score.

Results
No single biomarker yielded statistically significant differences between cases and controls. Median composite GBI was higher in cases than in controls (0.58, IQR − 0.36–1.69 vs. 0.32, IQR − 0.53–1.57, p = 0.33) and higher composite measures of GBI correlated with higher disease severity and ICU mortality (p < 0.001). In multivariable analysis, higher composite GBI was not significantly associated with increased occurrence of enterococcal bacteremia relative to CoNS bacteremia (adjusted OR 1.12 95% CI 0.93–1.34, p = 0.22).

Conclusions
We could not demonstrate an association between biomarkers of gastrointestinal barrier dysfunction and an increased occurrence of bacteremia due to gut compared to skin flora during critical illness, suggesting against bacterial translocation as a major vector for acquisition of nosocomial bloodstream infections in the ICU.
An end-to-end approach for blindly rendering a virtual sound source in an audio augmented reality environment
Authors: Saini Shivam , Engel Isaac , Peissig Jürgen 
Published: March 2024

AbstractAudio augmented reality (AAR), a prominent topic in the field of audio, requires understanding the listening environment of the user for rendering an authentic virtual auditory object. Reverberation time ($$RT_{60}$$

R

T
60

) is a predominant metric for the characterization of room acoustics and numerous approaches have been proposed to estimate it blindly from a reverberant speech signal. However, a single $$RT_{60}$$

R

T
60

value may not be sufficient to correctly describe and render the acoustics of a room. This contribution presents a method for the estimation of multiple room acoustic parameters required to render close-to-accurate room acoustics in an unknown environment. It is shown how these parameters can be estimated blindly using an audio transformer that can be deployed on a mobile device. Furthermore, the paper also discusses the use of the estimated room acoustic parameters to find a similar room from a dataset of real BRIRs that can be further used for rendering the virtual audio source. Additionally, a novel binaural room impulse response (BRIR) augmentation technique to overcome the limitation of inadequate data is proposed. Finally, the proposed method is validated perceptually by means of a listening test.
Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Aβ42 in Alzheimer’s disease and other neurodegenerative diseases
Authors: Kurihara Masanori , Matsubara Tomoyasu , Morimoto Satoru , Arakawa Akira , Ohse Kensuke , Kanemaru Kazutomi , Iwata Atsushi , Murayama Shigeo , Saito Yuko 
Published: March 2024

AbstractRecent studies suggest that increased cerebrospinal fluid (CSF) phospho-tau is associated with brain amyloid pathology rather than the tau pathology. However, confirmation using gold standard neuropathological assessments remains limited. This study aimed to determine background pathologies associated with aberrant CSF p-tau181 and amyloid-beta 1–42 (Aβ42) in Alzheimer’s disease (AD) and other neurodegenerative diseases. We retrospectively studied all patients with antemortem CSF and postmortem neuropathologic data at our institution. Comprehensive neuropathologic assessments were conducted for all patients, including Thal phase, Braak NFT stage, and CERAD score for AD. CSF concentrations of p-tau181 and Aβ42 were compared between AD neuropathological scores at autopsy by one-way ANOVA stratified by other pathologies. A total of 127 patients with AD (n = 22), Lewy body disease (n = 26), primary tauopathies (n = 30), TDP-43 proteinopathy (n = 16), and other diseases (n = 33) were included. The age at lumbar puncture was 76.3 ± 9.1 years, 40.8% were female, and median time from lumbar puncture to autopsy was 637 (175–1625) days. While Braak NFT 0–II was prevalent without amyloid pathology, Braak NFT ≥IV was observed exclusively in patients with amyloid pathology. Stratified analyses showed that CSF p-tau181 was slightly but significantly higher in patients with high Thal phase or CERAD score even in those with Braak NFT 0–II at autopsy. In patients with amyloid pathology, CSF p-tau181 was significantly and more profoundly elevated in those with Braak NFT ≥III at autopsy. CSF Aβ42 was lower in patients with high amyloid pathological scores. However, 34% with Thal ≤ 2 and 38% with CERAD ≤ sparse also showed decreased Aβ42. Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) were overrepresented in this group. These results neuropathologically confirmed previous studies that CSF p-tau181 levels were slightly elevated with amyloid pathology alone and were even higher with tau pathology, and that CSFAβ42 can be decreased in PSP/CBD.
A multi-level quantitative analysis method on the scale, shape and quantity of rockeries in Chinese classical gardens: taking Wanfang Anhe rockery in the Old Summer Palace as an example
Authors: Li Xinchen , He Xiaoxiao , Xiao Yuqing , Jia Shizhen , Qin Ke 
Published: March 2024

Abstract
Currently, the use of digital technology for the protection and research of cultural heritage has become a trend in this field. Rockeries in Chinese classical gardens have become an important cultural heritage type because of their unique shape, ingenious skills and rich connotations. Based on relevant historical information and 3D digital technology, this paper puts forward a multi-level quantitative analysis method on the scale, shape and quantity of rockeries in Chinese classical gardens, aiming at exploring the objective description and quantitative analysis path of rockeries at different levels. This method develops four levels: overall, regional, hierarchical, and individual and their corresponding quantitative contents, which in turn enable data extraction and analysis of the rockery through the different levels. The proposed method was applied to seven different Chinese classical garden rockeries, and taking Wanfang Anhe Rockery in the Old Summer Palace as an example for objective and comprehensive quantitative analysis and verification. The results show that this method is feasible and effective for quantitative analysis of the scale, shape and quantity of rockeries, which can help understand the basic background of stone rockeries and enhance a refined understanding of stone rockery construction, thereby providing data for preventive protection and informatization management of stone rockeries. The 3D rockery model database based on the overall, regional, hierarchical and individual quantitative analysis and numbering method brings a good application prospect for preventive protection and informatization management of the rockery.
The role of classifiers and data complexity in learned Bloom filters: insights and recommendations
Authors: Malchiodi Dario , Raimondi Davide , Fumagalli Giacomo , Giancarlo Raffaele , Frasca Marco 
Published: March 2024

AbstractBloom filters, since their introduction over 50 years ago, have become a pillar to handle membership queries in small space, with relevant application in Big Data Mining and Stream Processing. Further improvements have been recently proposed with the use of Machine Learning techniques: learned Bloom filters. Those latter make considerably more complicated the proper parameter setting of this multi-criteria data structure, in particular in regard to the choice of one of its key components (the classifier) and accounting for the classification complexity of the input dataset. Given this State of the Art, our contributions are as follows. (1) A novel methodology, supported by software, for designing, analyzing and implementing learned Bloom filters that account for their own multi-criteria nature, in particular concerning classifier type choice and data classification complexity. Extensive experiments show the validity of the proposed methodology and, being our software public, we offer a valid tool to the practitioners interested in using learned Bloom filters. (2) Further contributions to the advancement of the State of the Art that are of great practical relevance are the following: (a) the classifier inference time should not be taken as a proxy for the filter reject time; (b) of the many classifiers we have considered, only two offer good performance; this result is in agreement with and further strengthens early findings in the literature; (c) Sandwiched Bloom filter, which is already known as being one of the references of this area, is further shown here to have the remarkable property of robustness to data complexity and classifier performance variability.
Metabolic Consequences of Anabolic Steroids, Insulin, and Growth Hormone Abuse in Recreational Bodybuilders: Implications for the World Anti-Doping Agency Passport
Authors: Di Girolamo Filippo Giorgio , Biasinutto Chiara , Mangogna Alessandro , Fiotti Nicola , Vinci Pierandrea , Pisot Rado , Mearelli Filippo , Simunic Bostjan , Roni Chiara , Biolo Gianni 
Published: March 2024

Abstract
Background
Hormonal doping in recreational sports is a public-health concern. The World Anti-Doping Agency (WADA) promoted the creation of the Athlete Biological Passport, aiming to monitor athlete’s biological variables over time to facilitate indirect detection of doping. Detection tests for anabolic androgenic steroids (AAS) and growth hormone (GH) are available while insulin abuse cannot be revealed. We have determined in recreational bodybuilders the metabolic effects associated with different patterns of hormone abuse. All analyses were conducted using Statistical Package for Social Sciences (SPSS) 21.0 software (SPSS Chicago, IL).

Results
We have assessed plasma concentrations of selected metabolic markers and fatty acid content in erythrocyte membranes of 92 male bodybuilders and in 45 healthy controls. Hormonal abuse was identified by anonymous questionnaires. 43% (%) of recruited bodybuilders regularly abused hormones, i.e., anabolic androgenic steroids (95%) often associated with GH (30%) and/or insulin (38%). HDL-cholesterol was lower in insulin and/or GH abusers. Alanine (ALT) and aspartic (AST) transaminases were greater in hormone abusing bodybuilders than in non-doping bodybuilders and controls. Insulin doping was selectively associated with increased plasma ALT-to-AST ratio. In erythrocyte membranes, elongase activity (i.e., stearic-to-palmitic ratio) was lower in insulin and/or growth hormone doping, whereas increased Δ-9 desaturase activity (i.e., palmitoleic-to-palmitic ratio) was selectively associated with insulin doping.

Conclusions
In conclusion, our study demonstrates that insulin and GH abuse are characterized by multiple alterations of specific metabolic markers. Although further studies are needed to test whether longitudinal monitoring of selected metabolic marker such as muscle contraction time, HDL levels, ALT-AST ratio as well as the activities of selected enzymes (e.g. Δ-9 desaturase and elongase), could contribute to the detection of insulin and GH abuse in sport.