bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gut Microbiome, Diet and Depression: Literature Review of Microbiological, Nutritional and Neuroscientific Aspects
Authors: Clerici Laura , Bottari Davide , Bottari Benedetta 
Published: February 2025

Abstract

Purpose of Review
This review explores the intricate relationships among the gut microbiota, dietary patterns, and mental health, focusing specifically on depression. It synthesizes insights from microbiological, nutritional, and neuroscientific perspectives to understand how the gut-brain axis influences mood and cognitive function.

Recent Findings
Recent studies underscore the central role of gut microbiota in modulating neurological and psychological health via the gut-brain axis. Key findings highlight the importance of dietary components, including probiotics, prebiotics, and psychobiotics, in restoring microbial balance and enhancing mood regulation. Different dietary patterns exhibit a profound impact on gut microbiota composition, suggesting their potential as complementary strategies for mental health support. Furthermore, mechanisms like tryptophan metabolism, the HPA axis, and microbial metabolites such as SCFAs are implicated in linking diet and microbiota to depression. Clinical trials show promising effects of probiotics in alleviating depressive symptoms.

Summary
This review illuminates the potential of diet-based interventions targeting the gut microbiota to mitigate depression and improve mental health. While the interplay between microbial diversity, diet, and brain function offers promising therapeutic avenues, further clinical research is needed to validate these findings and establish robust, individualized treatment strategies.
Exceptional response to brigatinib following alectinib failure in a patient with ALK fusion-positive duodenal carcinoma
Authors: Sasaki Akinori , Chihara Sayaka , Okamoto Risa , Yoshino Takayuki , Nakamura Yoshiaki 
Published: February 2025

Abstract
Patients with advanced duodenal carcinoma typically have a poor prognosis due to limited practical chemotherapy options. While studies on genotype-directed therapy in patients with duodenal carcinoma is progressing, clinical data assessing the efficacy of molecularly targeted therapy remains scarce. We report the case of a 65-year-old woman diagnosed with anaplastic lymphocyte kinase (ALK) fusion-positive advanced duodenal carcinoma. The patient had been treated with alectinib for approximately 2 years for ALK-positive duodenal carcinoma but developed progressive liver metastases, indicating alectinib failure. During the disease progression, circulating tumor DNA (ctDNA) sequencing revealed the emergence of ALK L1196M mutation, which demonstrated sensitivity to brigatinib. After switching to brigatinib, marked shrinkage of liver metastases was observed. The patient maintained brigatinib treatment for 7 months until tumor progression. This is the first report demonstrating the efficacy of brigatinib after alectinib failure in a patient with duodenal carcinoma harboring ALK fusion. Furthermore, this case suggests that ctDNA sequencing can detect specific acquired mutations and help expand optimal treatment options for patients.
Budget-Constrained Runtime Allocation of Linked Data Services in Stream Processing
Authors: Han Jungkyu , Chun Sejin 
Published: February 2025

Abstract
Stream processing requires integrating with background knowledge in order to become rich knowledge. As a promising approach, it is getting important to combine streaming data with linked open data. However, since linked data change dynamically, it is impossible to synchronize their distributed data sources perfectly and seamlessly. To reduce the high cost of the synchronization, the materialized views (or views) that store local copies of remote sources are used but may degrade the accuracy of stream processing. To balance response time against accuracy, recent works manage a refresh budget—that is, the limited cost allocated for updating views over remote sources. However, they fail to allocate a refresh budget and produce a low accuracy when a tight deadline is given. To solve the problem, we propose an efficient method of allocating a refresh budget to view updates. The proposed method updates views both in the background and on demand. Experimental results with real and synthetic data sets show that the proposed method achieves superiority in terms of answer staleness, resource utilization, and refresh budget usage.
Taste Augmentation of Wine by Artificial Climate Room: Influence of Temperature and Humidity on Taste Evaluation
Authors: Igarashi Toshiharu , Ochiai Yoichi 
Published: February 2025

Abstract
This study investigates the effects of temperature and humidity on the subjective characteristics of wine through evaluations in two distinct environments: an artificial climate chamber and a conference room. Two wines, wine 1(CROIX DE BEAUCAILLOU 2011) and wine 2(BLAGNY 1ER CRU LA PIECE SOUS LE BOIS 2014), were analyzed. Significant differences in color intensity, aging degree, and body were observed for wine 1 in the artificial climate room, and in flavor intensity in the conference room. For wine 2, significant differences were detected in flavor intensity and aging degree in the artificial climate room. Additionally, the composition changes of the wines concerning temperature were examined, revealing correlations between specific acids and temperature changes. These findings indicate that wine taste can be optimized by adjusting environmental conditions based on wine type and personal preferences, suggesting the potential for climate-controlled environments in enhancing wine and food experiences in restaurants.
Petrogenesis of the alkaline lamprophyre cluster between Molí d’en Ponç and Collet de la Cidereda (eastern Catalonian Coastal Ranges, NE Iberia)
Authors: Culí Laura , Campeny Marc , Solé Jesús 
Published: February 2025

Abstract
This work focuses on the cretaceous camptonite cluster between Molí d’en Ponç and Collet de la Cidereda, eastern Montseny massif from the Catalan Coastal Ranges (NE Iberian Peninsula). These post-orogenic lamprophyres (~ 79 Ma) crosscut Palaeozoic and late Variscan granitoids. Their intrusion is related to the opening of the Bay of Biscay. Thus, they belong to the Late Cretaceous Iberian Alkaline Igneous Province. The studied cluster comprises two sills displaying a N110-N140-trending direction and subvertical dikes that intrude the camptonite sills or the granodioritic host rock. DyN/YbN ratios ≥ 2.4 show that the primary melts of the studied camptonites were generated at pressures higher than ~ 2.5 GPa (~ 80 km) on the garnet stability field close to the transition to the spinel stability field. The more evolved melts, corresponding to sodic alkaline basalts, were subjected to within-plate enrichment and fractional crystallization processes. The olivine antecrysts and microlites correspond to forsterite (Fo74 to Fo88). They do not show peridotitic mantle source composition and some are in equilibrium with sulfides. The clinopyroxene antecrysts correspond to diopside (Mg# 75–80) and do not show peridotitic mantle source composition. The forsterite, diopside, and kaersutite antecrysts display compositional oscillatory variations related to mixing processes associated with ascending successive magma pulses. The higher concentrations of Mn in forsterite and diopside microlites from the groundmass, compared to the antecrysts, are consistent with a more evolved composition of the ascending magma. The pressure estimation obtained from diopside antecryst cores (~ 1 GPa) supports the stagnation of ascending magma in the lower crust or the transitional boundary between the lower crust and upper mantle. The pressure obtained from clinopyroxene antecryst rims is ~ 0.28 GPa.
On hybrid quanvolutional neural networks optimization
Authors: Ceschini Andrea , Carbone Andrea , Sebastianelli Alessandro , Panella Massimo , Le Saux Bertrand 
Published: February 2025

Abstract
This paper investigates the optimization properties of hybrid quantum-classical quanvolutional neural networks (QuanvNNs), i.e., hybrid architectures merging quanvolutional layers with classical dense layers. We explore several optimization strategies by assessing 9 optimizers across various configurations of layers and kernel size. Through rigorous experimentation, it was found that optimizers such as Adabelief, RMSProp, and Adam outperform others, showcasing high accuracy scores. Conversely, Fromage, SM3, and Adagrad exhibit notably lower performance, highlighting the difficulty of effectively navigating the loss landscape. These findings emphasize the critical role of optimizer selection in a gradient-based variational optimization strategy. Additionally, quanvolutional layer parameters exhibit minimal fluctuations during the training phase, while classical parameters undergo variations on an order of magnitude higher. This disparity suggests a distinct behavior in the optimization dynamics between quantum and classical components, potentially influencing the efficacy of each layer type and offering valuable insights into the underlying mechanisms governing quanvolutional filters. We also evaluate QuanvNN robustness through comparisons against classical CNNs in scenarios involving few-shot learning and input perturbations. Our experimental findings underscore not only enhanced convergence capabilities of QuanvNNs, but also emphasize their superior efficacy in handling severely perturbed inputs. Finally, a randomized QuanvNN variant is tested, yielding comparable performance to optimized models as suggested by previous experiments on parameters variation. All these findings underscore the potential of QuanvNNs in offering robustness and optimization potential compared to their classical counterparts, with implications for quantum-enhanced machine learning.
An ultraviolet-C (UV-C) light device is effective for low-level disinfection of surgical site marking pens with UV-C transmissible caps
Authors: Milner Amelia L. , Cadnum Jennifer L. , Hailes Jennifer M. , Donskey Curtis J. 
Published: February 2025

Abstract
Single-use plastic pens are commonly used to mark surgical sites on the skin of patients. In laboratory testing, an ultraviolet-C (UV-C) light device was effective for decontamination of marking pens with plastic caps designed to allow transmission of UV-C. Decontamination of marking pens could reduce plastic and carbon footprints.
A mechanism that could stop the acceleration process within a collisionless shock
Authors: Bret Antoine , Pe’er Asaf 
Published: February 2025

Abstract
Collisionless shocks are complex non-linear structures that are not yet fully understood. In particular, the interaction between these shocks and the particles they accelerate remains elusive. Based on an instability analysis that relates the shock width to the spectrum of the accelerated particle and the shock density ratio, we find that the acceleration process could come to an end when the fraction of accelerated upstream particles reaches about 30%. Only unmagnetized shocks are considered.
Transcriptome-wide alternative splicing and transcript-level differential expression analysis of post-mortem Lewy body dementia brains
Authors: Goddard Thomas R. , Brookes Keeley J , Morgan Kevin , Aarsland Dag , Francis Paul , Rajkumar Anto P. 
Published: February 2025

Abstract
Lewy body dementias (LBD) are the second most common dementia. Several genes have been associated with LBD, but little is known about their contributions to LBD pathophysiology. Each gene may transcribe multiple RNA, and LBD brains have extensive RNA splicing dysregulation. Hence, we completed the first transcriptome-wide transcript-level differential expression analysis of post-mortem LBD brains for gaining more insights into LBD molecular pathology that are essential for facilitating discovery of novel therapeutic targets and biomarkers for LBD. We completed transcript-level quantification of next-generation RNA-sequencing data from post-mortem anterior cingulate (ACC) and dorsolateral prefrontal cortices (DLPFC) of people with pathology-verified LBD (LBD = 14; Controls = 7) using Salmon. We identified differentially expressed transcripts (DET) using edgeR and investigated their functional implications using DAVID. We performed transcriptome-wide alternative splicing analysis using DRIMseq. We identified 74 DET in ACC and 96 DET in DLPFC after Benjamini-Hochberg false discovery rate (FDR) correction (5%). There were 135 and 98 FDR-corrected alternatively spliced genes in ACC and DLPFC of LBD brains, respectively. Identified DET may contribute to LBD pathology by altering DNA repair, apoptosis, neuroplasticity, protein phosphorylation, and regulation of RNA transcription. We confirm widespread alternative splicing and absence of chronic neuroinflammation in LBD brains. Transcript-level differential expression analysis can reveal specific DET that cannot be detected by gene-level expression analyses. Therapeutic and diagnostic biomarker potential of identified DET, especially those from TMEM18, MICB, MPO, and GABRB3, warrant further investigation. Future LBD blood-based biomarker studies should prioritise measuring the identified DET in small extracellular vesicles.
Multiple Layers of Pan-Africanism and Pan-Ethiopianism in Current Debates on Nationalism and Ethnicity in Ethiopia
Authors: Záhořík Jan , Ylönen Aleksi , Lego Jonah 
Published: February 2025

Abstract
Since 2019, Ethiopia has embarked on a new “national project of peace and unity”. The government’s official discourse has been characterised by an uptake in the use of Pan-African and Pan-Ethiopian rhetoric. Strategically invoking visions of a united Africa and shared continental prosperity, the Abiy administration seeks to enhance its international reputation and rally African support for its domestic agenda. To overcome the pervasive ethnofractionalist tendencies in Ethiopia’s political landscape and consolidate the Ethiopian state within its present boundaries, the current government is selectively borrowing political strategies from previous administrations. This has produced a unique, new form of Pan-Ethiopian governance ideals. So far, the repercussions of this government discourse on political tensions in Ethiopia and the Ethiopian diaspora has received no scholarly attention. This academic article analyses the implications of the current Ethiopian government’s deployment of Pan-Africanist and Pan-Ethiopianist rhetoric on Ethiopia’s current political crises. This article argues that these Pan-Africanist and Pan-Ethiopianist rhetoric and ideals are paradoxically perpetuating divisive identity politics in Ethiopia’s domestic and diasporic political realm. This, in turn, exacerbates the most serious threat to Ethiopia’s national unity.
Menarche and pubertal progression: a cross-sectional analysis of timing and influencing factors in North-Eastern Ghana
Authors: Alatiah Gabriel Ajediwe , Azupogo Fusta , Atosona Ambrose , Vuvor Frederick , Steiner-Asiedu Matilda , Brouwer Inge D. 
Published: February 2025

Abstract
Menarche and pubertal onset vary across populations but understanding age-at-menarche (AAM) and pubertal growth tempo is limited in low-income settings. Identifying factors influencing pubertal development is vital for creating targeted health and education programmes supporting adolescent girls’ well-being. Baseline data (n = 1045) from the Ten2Twenty-Ghana study were analysed to examine menarche attainment, pubertal development, AAM, and the associated factors among girls aged 10-17 years in the Mion district, Ghana. The data collection methods included anthropometry, body composition, haemoglobin status, a qualitative 24-hour dietary recall, a food frequency questionnaire, and a pubertal development score (PDS). Binary logistic and linear regression analyses were used to model odds ratios for menarche attainment and regression coefficients for AAM and PDS. About 19.9% of the girls had experienced menarche, with a mean AAM of 13.4 ± 1.5 years. Among post-menarche girls (n = 205/1045), 12.2% and 15.1% experienced early (AAM < 12 years) and late menarche (AAM < 15 years), respectively. The mean PDS was 1.8 ± 0.7 out of 4. Among the adolescent girls, 36.2% were prepubertal, 17.0% early –pubertal, 18.6% mid-pubertal, 27.9% late pubertal, and less than 1% were in the post-pubertal stage. An increase in fat mass (FM), fat-free mass (FFM), height-for-age-z-score (HAZ), and body mass index-for-age-z-score (BAZ) was observed with puberty progression, but a steep decline in HAZ was noticed for girls in late puberty, increasing again post-puberty. Being older (adjusted odds ratio (AOR) = 2.06, 95% C.I.: 1.83, 2.31), stunted (AOR= 0.20, 95% C.I.: 0.10, 0.40), thin (AOR = 0.30, 95% C.I.: 0.11, 0.80), and overweight/obese (AOR = 7.29, 95% C.I.: 2.60, 20.43) were the significant predictors of menarche attainment. Being older (β = 0.39, P < 0.0001), stunted (β= -0.92, P = 0.01), thin (β = 1.25, P = 0.01), and having a literate mother (β = -0.72, P = 0.03) were significantly associated with AMM. A higher HAZ, FM, FFM, age, and Konkomba ethnicity were positively associated with higher PDS. This study highlights the complexity of factors influencing menarche and pubertal development. These insights are essential for developing targeted health and educational programmes that address nutritional and socio-demographic disparities to promote adolescent girls’ well-being and healthy pubertal development.
Previous hookworm infection attenuates the immune response to a subsequent Schistosoma mansoni infection in an experimental model
Authors: Furtado L.F.V. , Serafim L.R. , da Silva V.J. , Dias S.R.C. , de Paiva N.C.N. , Carneiro C.M. , Rabelo É.M.L. 
Published: February 2025

Abstract
This study investigated the co-infection dynamics of Schistosoma mansoni and Ancylostoma ceylanicum in an experimental model. Two experiments were conducted to investigate varying infection orders. In experimental group 1, subjects were initially infected with A. ceylanicum, followed by S. mansoni infection. In group 2, subjects were first infected with S. mansoni, followed by A. ceylanicum infection. The co-infected groups were compared to mono-infected groups for further analysis. Parameters assessed included weight, fecal egg elimination, blood cell counts, IgG response, histopathological analysis, and granuloma morphometry. Results indicated that the timing of infections influenced weight loss. Co-infected animals lost weight similarly to A. ceylanicum-infected animals when A. ceylanicum preceded S. mansoni. The co-infected groups did not experience worsened anemia, despite both parasites being hematophagous. No linear correlation was found between S. mansoni egg counts and anti-SEA IgG production. The response to the S. mansoni adult worm antigen was significantly higher in the S. mansoni mono-infected group compared to the group previously infected with hookworm. Co-infection with A. ceylanicum after S. mansoni infection also interfered with the host response. It caused a delay in the peak of S. mansoni egg elimination compared to the S. mansoni monoinfected group. Additionally, fewer eggs were retained in the liver compared to single infections. These findings help elucidate the interactions between different parasites and their hosts in the same endemic area, providing valuable information to enhance strategies for disease control and management.
Post-larval development and growth intraspecific variations in Ophiocoma echinata and Ophiocoma trindadensis from Brazil (Echinodermata: Ophiuroidea)
Authors: Damiano Cecília J. S. , Serrano Helena , Alitto Renata A. S. , Mendonça Joel B. , Tavares Marcos , Borges Michela 
Published: February 2025

Abstract
Identifying cryptic species and juveniles in the Ophiuroidea has always been a challenge. However, post-larval developmental studies have the potential to uncover the identity of these cryptic species and juveniles, as they offer valuable information that is not often found in adults. Although the importance of studying growth series is well-known in ophiuroids, it is difficult to obtain and identify the juvenile stages. For this reason, most studies are restricted to brooding species and information is lacking for many species, including those of the genus Ophiocoma. In this study, a growth series was developed to show the main differences during the development of two similar species of Ophiocoma: Ophiocoma echinata and Ophiocoma trindadensis. Using morphometry and scanning electron microscopy, we describe in detail the juveniles, intermediate stage, and adults of O. echinata and O. trindadensis. Differences in the shape of the ventral arm plate and dorsalmost arm spines, the number of tentacle scales, and the presence of granules ventrally were highlighted in the separation and identification of juveniles of both species.
Quantitative relationship of Sr:Ca of statoliths of the Japanese flying squid (Todarodes pacificus) with empirical water temperatures
Authors: Yamaguchi Tadanori , Matsui Hajime , Miyahara Hisae , Kubota Hiroshi , Hirose Naoki 
Published: February 2025

Abstract
The Japanese flying squid, Todarodes pacificus, is distributed mainly in the northwest Pacific and the Japan Sea. The present study was conducted for a better understanding of the mechanisms behind its migration routes. The ratios of strontium to calcium (Sr:Ca) in the statoliths can be associated with the water temperatures the squid experienced in the sea. Using specimens collected in the northern Japan Sea in summer and Lagrangian backward tracer experiments, a strong negative correlation was obtained between the Sr:Ca in the statoliths and the empirical water temperatures estimated through a regional ocean model. These backward tracer experiments were continuously conducted at depths of 6, 15, and 30 m. The greatest determination coefficient of the regression expression appeared for a nearshore tracer group of the experiment at a depth of 15 m. In addition, the regression expression provided reasonable lifetime empirical water temperature variations of the squids collected in the sea areas east of Tsushima Island and west of the Goto Islands in winter. The combination of Ca:Sr analytical chemistry and tracer experiments with the ocean dynamic model used in this study improved our understanding of the migration path of T. pacificus.