bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cannabis sativa L. - An Important Medicinal Plant: A Review of its Phytochemistry, Pharmacological Activities and Applications in Sustainable Economy
Authors: Saifi Muhammad Sahil , Arif Muhammad , Kaish M d , Kushwaha Shom Prakash 
Published: March 2024

Since the beginning of time, medicinal plants have served as a source of healing for almost all cultures. Cannabis sativa Linn. also known as Hemp is an herbaceous, anemophilous plant in the Cannabaccae family. Cannabis sativa L. is a unique natural medicinal plant holding a lot of phytochemicals such as cannabinoids, non-cannabinoids phenols, alkaloids, terpenes, and flavonoids. Each category of phytochemicals holds a lot of different compounds used in various forms of disease such as epilepsy, pain, bowel diseases, appetite stimulator, and many other neuro and GIT diseases. It was very popular as a medication in the treatment of COVID-19 and utilized in a sustainable economy. It contributes to the sustainable economy as bio-fuel, car parts, paper, food, apparel, building materials, ropes, carpets, and so on. The numerous therapeutic characteristics and phytochemical studies, as well as their use in a sustainable economy, demonstrate its value as a useful medicinal plant.
Formulation of Psoralea Ethosomes and their Evaluation
Authors: Sunita  , Sharma Akanksha 
Published: March 2024

Psoralea corylifolia known as ‘babchi’ is a medicinal plant for the treatment large scale level in pharmaceutical industries to cure various skin diseases. In India, indigenous herbal remedies such as Ayurveda and other Indian traditional medicines have since ancient times used plants in treatment of various disorders. In our present investigation, preliminary phytochemical analysis of Psoralea corylifolia has been evaluated for the presence of bioactive constituents using various polarity solvents including hexane, n butanol, ethanol and water. The present phytochemical screening of the seeds extracts revealed the presence of maximum compounds including carbohydrates, terpenoids, alkaloids, phenols, tannins, amino acid, cardiac glycosides and proteins. The results suggest that the ethanolic extracts of Psoralea corylifolia has promising therapeutic potential and can be used as a base for the development of novel potent drugs in phytomedicines.
Unraveling Drug Safety: Importance of Toxicological Screening and Animal Models in Pharmacokinetics Studies for Clinical Medicinal Impact
Authors: Bisht Tanuja , Dhoundiyal Shivang , Adhikari Anupriya , Patil Shivanand 
Published: March 2024

The pharmacokinetics of a drug is an important factor in determining the safety of the drug. In this review, we focus on the importance of the toxicological screening and the methods using various animal models to determine any signs of toxicity in the drug substance. The toxicity data acquired is used to determine the relationship among the serum composition and the toxicity results, as well as their purpose and importance to the drug's clinical medicinal impacts. in silico models which generally utilize the help of computers study the parameters of ADME in an artificial environment and generally costlier model i.e., animal model is used in the later stages of testing of medications potency and hazards. In vitro studies are conducted in rats and are conducted firstly to offer data for different regions of body favoring pharmacological investigations. The radiation levels determined by quantitative whole-body autoradiography amongst various tissues at different point of time are important to study that why some compounds fail to exhibit favorable PK during preclinical ADME screening, this information could be immensely helpful to medicinal chemists for improvement of the weak backbones. Preclinical studies are modest, but they can become better if all the test procedure are followed in the right manner and right evidence is provided which highlights the desired biological effect at the same time risk assessment methods should also take place in case of any severe adverse effects.
Gymnema sylvestre Leaf Hydroalcoholic Extract: Promising Source of Antioxidants with Remarkable Yield and Potent Scavenging Activity
Authors: Hasan Faizul , Naaz Shaista , Praveen Asma 
Published: March 2024

This research study aimed to compare the antioxidant activity and yield of different extracts of leaf of Gymnema sylvestre, including methanolic, hydroalcoholic, and aqueous extracts. In recent years, extensive research has been conducted to explore the antioxidant potential of Gymnema sylvestre extracts. However, a comprehensive comparison of these extracts in terms of their yield and antioxidant activity is lacking. Therefore, the objective of this study was to evaluate and compare the yield and antioxidant activity of different extracts of Gymnema sylvestre, specifically methanolic, hydroalcoholic, and aqueous extracts. The percentage yield of each extract was determined, providing valuable insights into the efficiency of the extraction methods. Furthermore, the antioxidant activity of the extracts was assessed by measuring their scavenging activity and determining the IC50 values. Methanolic, hydroalcoholic, and aqueous extracts of Gymnema sylvestre leaf were obtained using the Soxhlet extraction method after being finely pulverized. Within the limitations of this study, it was concluded that the hydroalcoholic extract of Gymnema sylvestre exhibited the highest percentage yield, with a recorded value of 10.27 percent. The IC50 values for the Gymnema extract and Ascorbic acid were determined to be 59.09 µg/ml and 44.90 µg/ml, respectively. These findings indicate the potential antioxidant activity of Gymnema sylvestre extracts, with the hydroalcoholic extract showing the most promising results in terms of both yield and scavenging activity. Further investigations are needed to explore the underlying mechanisms and assess the potential health benefits of these extracts in various applications.
Application of biopolymers in clothing and fashion
Authors: Sharma Aditya , Jha Adarsh 
Published: March 2024

The use of biopolymer fibres in textile technology predates written human history. Researchers and academics are looking at plant fabrics for potential use in cutting-edge technologies because of their low environmental impact and long lifespan. The use of nonbiodegradable petrochemical materials in fast fashion's trendy, low-priced clothes has increased in frequency. The development, manufacturing, and disposal of these materials have all contributed to environmental degradation. Materials that incorporate biopolymers are often promoted as biobased, biodegradable, or possessing all of these qualities. Biopolymers textiles with improved degradability performance are reviewed, as is the utilisation of this intelligent bio textile as a low or no-cost replacement for commercial chemical-based textiles. This book will also explain how these cutting-edge modelling techniques might help polymer designers settle on the most optimal solution. In addition to reducing expenditures on resources, production, and processing, the entirely biodegradable polymers also provide support for the textiles industry, Biodegradable polymers' recent advancement and prospective future uses and trends in the contemporary biodegradable textiles industry will be discussed. The transition from synthetic to bio-based materials is inevitable, although it is happening slowly due to technological hurdles. The use of biopolymers offers several benefits, including the manufacture of an eco-friendly final product and lightweight textiles with cheap production costs. A lot of work has gone into making bio-textiles that can meet the needs of the future, like ensuring their superiority in all respects and acquiring textile substrates with prospective capabilities like antimicrobial, fireproof, resistant to ultraviolet light, conductive to electricity, and very hydrophobic. We'll be discussing we'll examine how eco-friendly biopolymers can be incorporated at various points in the textile production process. Biopolymers are more environmentally conscientious than other cutting-edge technologies because they could help future generations save money, energy, and raw resources.
"Unlocking the Healing Power of Gramicidin: Exploring Medicinal Marvels, Current Breakthroughs, and Promising Horizons from Bacillus brevis"
Authors: Agam Kunal , Arya Dilip Kumar 
Published: March 2024

ABSTRACT: Gramicidin is an antimicrobial peptide that has been studied extensively in recent years due to its potential as a novel drug for treating microbial infections. Recent studies have characterized gramicidin's structure, function, mechanism of action and efficacy against various bacterial species. In addition, gramicidin-based drugs have been found to be effective against gram-negative bacteria and fungi, making them promising candidates for future medical applications. This review intends to provide an update on the current knowledge of gramicidin, including its medicinal use and characterization studies, as well as its potential prospects in the development of new antimicrobial therapeutics. It will also discuss some of the challenges and opportunities associated with gramicidin based drugs and their future in the medical field. Ultimately, this review will provide insight into gramicidin's potential for novel drug discovery and development. Furthermore, gramicidin has been found to have a low toxicity profile and is well-tolerated by patients. This makes gramicidin an attractive candidate for the development of new antimicrobial agents. Moreover, gramicidin-based drugs have shown promise in the treatment of gram-negative bacteria and fungi, providing promising avenues for the development of gramicidin based therapeutics. Finally, gramicidin's potential as a novel drug for treating microbial infections has been highlighted and there is still much to be explored in terms of its medicinal uses and prospects in the medical field. In conclusion, gramicidin has great potential as an antimicrobial drug and has been characterized extensively in recent years. With continued research, gramicidin-based drugs could play a significant role in the development of novel therapeutics for treating microbial infections in the future.
Rudimentary Review on Molecular Docking: A Beginner’s Guide
Authors: Tiwari Shashank , Prakash Kartikay , Soni Devbrat 
Published: March 2024

The computer modelling of structural complexes generated from two or more interacting molecules are referred to as molecular docking. It is an indispensable tool in computer-aided drug design and structural molecular biology. Using this technology, large libraries of compounds may be digitally screened, and the results can be graded along with structural assumptions about how the ligands impact the target's reduction. Recent advances in the synthesis of anti-infectious medicines prompted by structural insights have enabled the application of computer-assisted drug design in the quest for innovative mechanism- or structure-based drugs. Molecular docking is an important phase in the drug development process because it determines the best positions for molecules to occupy when they are coupled together and predicts how effectively two molecules will bind once they have been docked. The input structure's design is also critical, and the results are assessed using sampling methods and scoring systems. The recently developed docking software Local Move Monte Carlo [LMMC] provides a strong choice for customizable receptor docking strategies. Docking is a technique for determining how ligands and proteins interact. It is structurally sound and compatible with computer-assisted medication design. Successful docking discovers high-dimensional spaces and ranks function utilisation, resulting in a candidate docking rating that is acceptable. It may also be used to screen vast libraries of molecules and offer structural hypotheses for the process.
Cosmeceuticals: The Fusion of Beauty and Science
Authors: Khan Saba , Yadav Sheela 
Published: March 2024

Cosmeceuticals represent an innovative product category positioned between cosmetics and pharmaceuticals, aimed at improving both skin health and its aesthetic qualities. As an ever growing sector within the skincare industry, cosmeceuticals are crafted using a wide range of ingredients, which we will delve into in this article by categorizing them into primary groups. Given the increasing interest among consumers in these products and the strong marketing claims made by manufacturers, physicians must become acquainted with these agents, and comprehend their benefits, limitations, and potential adverse effects.
Estimation of Organic Metabolites in Root Knot Nematode-Infested
Authors: Gupta Spinach Shalini 
Published: March 2024

The Nematodes contain an enormous phylum of creatures that incorporates plant and creature parasites as well as some free-living species. Soil is a rich living space for nematodes, with around 26% of portrayed genera occupying soil as bacterivores, fungivores, omnivores, hunters or plant parasites. It is said that any place there is soil there are nematodes. Nematodes might harm plants straightforwardly or by implication. As a rule, the nematode invasion in fields is poly explicit; be that as it may, contingent on the agro-climatic conditions, a couple of animal types overwhelms over the rest. Meloidogyne incognita is all around damaging to practically every one of the plants including vegetables, foods grown from the ground cereal yields. Spinach (Spinacea oleracea) is additionally viewed as plagued by something very similar. Biocontrol with strips of Citrus aurantifolia (kaghzi neemboo) demonstrated gainful in controlling the invasion. Different natural metabolites were assessed in root tie nematode invaded spinach. Among natural metabolites chlorophyll, absolute carbs, all out free amino acids were assessed. Root tie nematode invaded spinach was treated with lemon's strips, which demonstrated valuable as far as expanded chlorophyll content. Adjusted complete carb and absolute free amino corrosive substance was found with S/4 of lemon strips treated spinach plants.
Automation in Pharmacovigilance
Authors: Jain Ashish , Kumar Davinder , Kumar Abhimit , Chauhan Dolly 
Published: March 2024

The term “pharmacovigilance,” first proposed in the1970s, has gradually gained traction to become one of the two common terms of art for the overall discipline, the other, older term being “drug safety.” “World Health Organization (WHO)” as “the science and activities relating to the detection, assessment, understanding and prevention of drug-related problems”. The information about suspect product is collected from healthcare providers and patients to detect and prevent abnormalities associated with it. Therefore, PV deals with adverse effects of drug, poly-pharmacy, paradoxical reactions, and severe adverse events. Automation in pharmacovigilance entails using cognitive technologies such as machine learning (ML) and advanced analytics to transform legacy data compilation processes and information gathering for regulatory approval. Automation technologies have strong potential to automate routine work and balance resource use across safety risk management and other pharmacovigilance activities. This article provides an overview of automation in pharmacovigilance.
Impact of Digitalization on the Healthcare System
Authors: Jain Ashish , Ray Dipendra Kumar , Ranjan Suttu Sneh , Kumar Ashish , Jamwal Yamini 
Published: March 2024

Abstract: Digitalization is a pressing necessity with enormous potential to alter economic growth parameters, forging a mutually beneficial relationship with employment generation and long-term sustainability. The domain of healthcare has been moving into the digital world relatively late and only recently has started with digitalizing processes and services on a larger scale. Still, the potential for disruption in the healthcare industry is enormous. Healthcare digitization brings about many benefits to both patients and healthcare professionals throughout different stages in the patient journey. In this paper we review existing impact of digitalization in healthcare system. Digital health indeed needs to be seen as a broad concept whereby the purposes of healthcare are served through technologies that are combined for universal healthcare access, applications across various multi-disciplinary fields and ecosystems in healthcare and the health journey of people, as patients needing (access to) care and as citizens enabled to live healthier and prevent sickness. We conclude by outlining the implications and benefits of digitizing healthcare. There is a potential to improve healthcare by digitalization.
Review on " Hepatocellular carcinoma"
Authors: Yadav Neha , Gupta Nidhi , Bharatia Rakesh 
Published: March 2024

Hepatocellular carcinoma is a problem for the world's Hepatocellular carcinoma, metabolic syndrome, stage of liver cancer local disease, liver cirrhosis, treatment. syndrome or diabetes mellitus is increasingly common in the west. Furthermore, HCC with non-alcoholic steatohepatitis-associated molecular pathogensis is distinct. A quarter of all HCCs have potentially treatable mutations that have not yet been applied in clinical settings. When clinical deterioration occurs, HCC is frequently detected, and survival is then assessed as a risk factor. utilizing alfa-fetoprotein (AFP), a serum maker, frequently in conjunction with ultrasound. The accuracy of monitoring is currently being improved by testing a number of other serologic indicators. More advanced imaging techniques, such CT scan and MRI, which have multiphasic contract enhancing capabilities, are frequently needed for the diagnosis of HCC. When serum AFP levels are significantly increased, which happens in less than half of cases at the time of diagnosis, it can be useful to use serum AFP alone. When the diagnosis of HCC is still undetermined, a liver biopsy might be used to confirm the diagnosis. The present requirement for molecular information, which necessitates tissue or liquid biopsies, challenges diagnosis based on non-invasive criteria. The management of patients with advanced HCC has been altered by recent significant developments. Checkpoint inhibitors, tyrosine, and even combinations of two immunotherapy treatments are among the combination medicines that new trials are investigating. The results of these trials are anticipated to alter the HCC management environment at all evolutionary stages.
Review on " Current Advancements in Niosomes"
Authors: Bharatia Rakesh , Gupta Nidhi , Upadhyay Preeti , Kumar Shailendra , Kumar Vipul 
Published: March 2024

Non-ionic surfactants self-assemble into vesicular systems called niosomes in aqueous solutions with the help of physical agitation or high temperatures. Nonionic surfactants, as opposed to phospholipids, are used as the constituents of the membrane, which circumvents many of the drawbacks of liposomes, including inadequate chemical stability, phospholipids' oxidation susceptibility, high production costs, and the need for particular handling and storage conditions. Because of their unique shape, which consists of an inner aqueous compartment encircled by a hydrophobic membrane, hydrophilic and hydrophobic drug molecules can be incorporated and delivered, respectively. In addition, niosomes are biocompatible, biodegradable, nontoxic, and osmotically active. Niosomes were first proposed as a workable solution for the cosmetics industry in the 1970s, and in the 1980s, L'Oreal filed for patents on the ingredient. Their advantageous qualities establish theIn recent times, there has been a dramatic shift in the treatment of infectious diseases and vaccination strategies. Along with the creation of many biologicals targeted at specific diseases, biotechnology and genetic engineering have also brought attention to the effective delivery of these biologicals. Niosomes, which are vesicles made of non-ionic surfactants and less expensive than liposomes, are biodegradable, harmless, stable, and less expensive than liposomes. This article summarizes various studies that have examined the effectiveness of using niosomes for various diseases.
THEORETICAL FRAMEWORKS FOR THE ROLE OF AI AND MACHINE LEARNING IN WATER CYBERSECURITY: INSIGHTS FROM AFRICAN AND U.S. APPLICATIONS
Authors: Fatai Adeshina Adelani  , Enyinaya Stefano Okafor  , Boma Sonimiteim Jacks  , Olakunle Abayomi Ajala  
Published: March 2024

This review paper explores the theoretical frameworks underpinning the application of Artificial Intelligence (AI) and Machine Learning (ML) in enhancing cybersecurity within the water sector, with a focus on both African and U.S. contexts. It delves into the unique cybersecurity challenges faced by the water sector, emphasizing the critical role of AI and ML in identifying, predicting, and mitigating cyber threats. The paper discusses the ethical considerations and regulatory frameworks influencing the deployment of these technologies alongside the technical, socioeconomic, and data privacy challenges encountered. Future directions and emerging trends in AI and ML that could impact water cybersecurity are examined, offering insights into potential research areas and strategies for overcoming existing barriers. This comprehensive review underscores the importance of integrating AI and ML into water cybersecurity strategies to safeguard critical water infrastructure.
Keywords: Artificial Intelligence, Machine Learning, Water Cybersecurity, Ethical Considerations, Regulatory Frameworks, Emerging Trends.
EXPERIÊNCIA DE MONITORIA ONLINE NA DISCIPLINA DE TECNOLOGIA DE CARNES, AVES E OVOS: PROMOVENDO CONHECIMENTO E MELHORIA DA QUALIDADE DE ENSINO
Authors: Pinto Claudia Jemima Passos , Leite Pedro Alexandre Gomes , Souza Marcelo dos Santos , Maciejewsky Raquel Lomes , Silva Giulia Likoski da , Silva José Herison Albuquerque da 
Published: March 2024

A educação online está cada vez mais presente nos cenários acadêmicos, oferecendo oportunidades de aprendizado flexíveis e constantes, neste contexto, a monitoria online urge como ferramenta oportuna no auxílio à qualidade do ensino, à medida que a promoção e disseminação do conhecimento proporciona difusão de conhecimento através da capacitação teórica e prática por ensino remoto, permite a produção de materiais didáticos.Com o advento da pandemia do Covid-19 urgiu-se a necessidade da realização de aulas online, e em razão da não realização das aulas práticas presenciais, foi constatado que a oferta de monitoria no formato virtual possibilitaria a capacitação aos discentes sem muitos prejuízos, em virtude do período letivo atípico. No presente artigo, exploramos a experiência de monitoria online na disciplina de Tecnologia de Carnes, Aves e Ovos, destacando sua relevância e impacto no processo de aprendizagem dos estudantes.