bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonketotic hyperglycemia hemichorea and hemiballismus: a case report
Authors: Dixit Abhishek 
Published: March 2024

Abstract
Background
Diabetic striatopathy, also known as hyperglycemic hemichorea-hemiballismus, is a rare movement disorder associated with nonketotic hyperglycemia in patients with poorly controlled diabetes mellitus. The pathophysiology is not fully elucidated but may involve hyperviscosity, ischemia, and alterations in basal ganglia neurotransmitters.

Case presentation
We present a case of a 64-year-old Asian female patient with longstanding poorly controlled type 2 diabetes mellitus who developed abrupt-onset right-sided hemichorea-hemiballismus. Laboratory results showed hyperglycemia without ketoacidosis. Neuroimaging revealed left putaminal hyperdensity on computed tomography and T1 hyperintensity on magnetic resonance imaging. With insulin therapy and tetrabenazine, her movements improved but persisted at 1-month follow-up.

Discussion
This case illustrates the typical features of diabetic striatopathy, including acute choreiform movements contralateral to neuroimaging abnormalities in the setting of nonketotic hyperglycemia. While neuroleptics may provide symptomatic relief, prompt glycemic control is critical given the risk of recurrence despite imaging normalization.

Conclusion
Diabetic striatopathy should be recognized as a rare disorder that can occur with poorly controlled diabetes. Further study of its pathophysiological mechanisms is needed to better guide management. Maintaining tight glycemic control is essential to prevent recurrence of this debilitating movement disorder.
Sustained mitigation of ST-segment elevation in a patient with Brugada syndrome type 1 during sevoflurane and remifentanil anesthesia: a case report
Authors: Saito Kurumi , Yoshida Hitoshi , Hirota Kazuyoshi 
Published: March 2024

Abstract
Background
During general anesthesia, patients with Brugada syndrome are at risk of malignant arrhythmias following worsened ST-segment elevation, potentially leading to sudden cardiac death. The protocol for safe anesthetic management of patients with Brugada syndrome has not yet been established.

Case presentation
A 63-year-old man, diagnosed with a spontaneous Brugada type 1 pattern, was scheduled for a pleural biopsy using video-assisted thoracoscopic surgery under general anesthesia. We planned general anesthesia using volatile induction and maintenance anesthesia with sevoflurane and remifentanil. We monitored ST-segment morphology and observed sustained mitigation of ST-segment elevation throughout general anesthesia.

Conclusion
The present case may indicate that safe anesthetic management of patients with Brugada syndrome depends on whether the anesthetics used can reduce ST-segment elevation.
Medicinal cannabis for treating post-traumatic stress disorder and comorbid depression: real-world evidence
Authors: Lynskey Michael T. , Athanasiou-Fragkouli Alkyoni , Thurgur Hannah , Schlag Anne Katrin , Nutt David J. 
Published: March 2024

Background
Cannabis-based medicinal products (CBMPs) are increasingly being used to treat post-traumatic stress disorder (PTSD), despite limited evidence of their efficacy. PTSD is often comorbid with major depression, and little is known about whether comorbid depression alters the effectiveness of CBMPs.

Aims
To document the prevalence of depression among individuals seeking CBMPs to treat PTSD and to examine whether the effectiveness of CBMPs varies by depression status.

Method
Data were available for 238 people with PTSD seeking CBMP treatment (5.9% of the treatment-seeking sample) and 3-month follow-up data were available for 116 of these. Self-reported PTSD symptoms were assessed at treatment entry and at 3-month follow-up using the PTSD Checklist – Civilian Version (PCL-C). The probable presence of comorbid depression at treatment entry was assessed using the nine-item Patient Health Questionnaire (PHQ-9). Additional data included sociodemographic characteristics and self-reported quality of life.

Results
In total, 77% met screening criteria for depression, which was associated with higher levels of PTSD symptomatology (mean 67.8 v. 48.4, F(1,236) = 118.5, P < 0.001) and poorer general health, quality of life and sleep. PTSD symptomatology reduced substantially 3 months after commencing treatment (mean 58.0 v. 47.0, F(1,112) = 14.5, P < 0.001), with a significant interaction (F(1,112) = 6.2, P < 0.05) indicating greater improvement in those with depression (mean difference 15.3) than in those without (mean difference 7).

Conclusions
Depression is common among individuals seeking CBMPs to treat PTSD and is associated with greater symptom severity and poorer quality of life. Effectiveness of CBMPs for treating PTSD does not appear to be impaired in people with comorbid depression.
Glycerol Phenylbutyrate Treatment of 2 Patients With Monocarboxylate Transporter 8 Deficiency
Authors: Zung Amnon , Sonntag Niklas , Schweizer Ulrich , Banne Ehud , Braun Doreen 
Published: March 2024

AbstractContextMonocarboxylate transporter 8 (MCT8) deficiency is a rare genetic disease that leads to severe global developmental delay. MCT8 facilitates thyroid hormone (TH) transport across the cell membrane, and the serum TH profile is characterized by high T3 and low T4 levels. Recent studies have shown that the chemical chaperone sodium phenylbutyrate (NaPB) restored mutant MCT8 function and increased TH content in patient-derived induced pluripotent stem cells, making it a potential treatment for MCT8 deficiency.ObjectiveWe aimed to assess the efficacy and safety of glycerol phenylbutyrate (GPB) in MCT8 deficiency.MethodsWe treated 2 monozygotic twins aged 14.5 years with MCT8 deficiency due to P321L mutation with escalating doses of GPB over 13 months. We recorded TH, vital signs, anthropometric measurements, and neurocognitive functions. Resting metabolic rate (RMR) was measured by indirect calorimetry. Serum metabolites of GPB were monitored as a safety measure. In vitro effects of NaPB were evaluated in MDCK1 cells stably expressing the MCT8P321L mutation. The effects of GPB were compared to the effects of DITPA and TRIAC, thyromimetic medications that the patients had received in the past.ResultsNaPB restored mutant MCT8 expression in MDCK1 cells and increased T3 transport into cells carrying the P321L mutation. GPB treatment reduced high T3 and increased low T4 levels. The patients showed a significant weight gain simultaneously with a reduction in RMR. Only minor neurocognitive improvement was observed, in hyperreflexia score and in cognitive functions. Serum metabolites did not exceed the toxic range, but elevated liver transaminases were observed.ConclusionIn the first report of GPB treatment in MCT8 deficiency we found an improvement in TH profile and body mass index, with minor neurodevelopmental changes.
The BDNF Protein is Associated With Glucose Homeostasis and Food Intake in Carriers of Common BDNF Gene Variants
Authors: Miksza Urszula , Bauer Witold , Roszkowska Joanna , Moroz Monika , Buczynska Angelika , Wiatr Aleksandra , Gorska Maria , Adamska-Patruno Edyta , Kretowski Adam 
Published: March 2024

Abstract

Context
Brain-derived neurotrophic factor (BDNF) concentrations may differ between BDNF genotype carriers. These changes occur in individuals with metabolic and mental disorders.

Objective
The aim of this study was to assess the associations of glucose homeostasis parameters and the frequency of food consumption with BDNF protein concentrations based on BDNF single nucleotide polymorphisms (SNPs).

Methods
Among the 439 participants, some common rs10835211 BDNF gene variants were analyzed. We evaluated BDNF concentrations, and measured glucose and insulin after fasting and during oral glucose tolerance tests. Anthropometric measurements, body composition, and body fat distribution were assessed, and a 3-day food intake diary and food frequency questionnaire were completed.

Results
We observed significant differences in BDNF concentration between AA and AG genotype rs10835211 carriers (P = .018). The group of AA genotype holders were older, and positive correlation was found between age and BDNF in the whole study population (P = .012) and in the GG genotype carriers (P = .023). Moreover, BDNF protein correlated with fasting insulin (P = .015), HOMA-IR (P = .031), HOMA-B (P = .010), and the visceral/subcutaneous adipose tissue (VAT/SAT) ratio (P = .026) in the GG genotype individuals. Presence of the GG genotype was negatively correlated with nut and seed (P = .047) and lean pork consumption (P = .015), and the BDNF protein. Moreover, we observed correlations between the frequency of chicken (P = .028), pasta (P = .033), and sweet food intake (P = .040) with BDNF concentration in the general population. Among carriers of the AA genotype, we observed a positive correlation between the consumption of rice (P = .048) and sweet food (P = .028) and the BDNF protein level.

Conclusion
Peripheral BDNF may be associated with VAT content and insulin concentrations in GG genotype carriers and may vary with particular food intake, which warrants further investigation.
Elagolix Represents a Less Invasive and Cheaper Option Than Injectable GnRH Antagonist for Ovulation Suppression in IVF
Authors: Mouanness Marco , Merhi Zaher 
Published: March 2024

Abstract

Background
The injectable gonadotropin-releasing hormone (GnRH) antagonists have traditionally been used for ovulation suppression during controlled ovarian hyperstimulation for in vitro fertilization (IVF), leading to increased painful daily injections and cost. The use of the oral GnRH antagonist elagolix for ovulation suppression in IVF has not been studied.

Methods
This retrospective cohort study of patients undergoing IVF who received either oral elagolix 50 mg every other day or ganirelix/cetrotide injection daily for ovulation suppression during controlled ovarian hyperstimulation included 269 patients, 173 in the elagolix group and 96 in the ganirelix/cetrotide group. The main outcome was the suppression of luteinizing hormone (LH) blood levels, reflecting ovulation suppression.

Results
Age, body mass index, anti-Müllerian hormone, baseline follicle-stimulating hormone, antral follicles count, dose of medications used, number of days of ovarian stimulation, and peak estradiol (E2) levels were similar in both groups. When blood LH and E2 levels were measured before intake and the day after intake of either elagolix or ganirelix/cetrotide, both groups had significant and similar drop in LH levels and increase in E2 levels. When comparing IVF cycle outcomes in both groups, the number of oocytes retrieved, number of mature oocytes, fertilization rate, blastocyst formation rate, euploidy rate, and endometrial lining thickness at the time of the trigger were all similar.

Conclusion
Oral GnRH antagonist, a much cheaper and less invasive medication that is used at a lower frequency, showed comparable ovulation suppression to the costly injectable GnRH antagonist. Further studies are required to evaluate the effect of oral GnRH antagonist on endometrial lining receptivity and pregnancy outcomes, especially when using fresh embryo transfer IVF protocols.
20.YÜZYIL ÖZELİNDE BAZI GELENEKSEL KADIN GİYSİLERİNİN KORUNARAK SAKLANMASI
Authors: ÖNGEN Ayşe Gamze 
Published: March 2024

Türklerde giyim-kuşam, önemli kültürel bir değer olarak, öne çıkmaktadır. Bu nedenle, tarihi giysilerin bilinirliliğini sağlamak adına, bu eserlerin gelecek nesillere aktarılabilmesi için korunarak saklanmalırı gerekir. Bu çalışma, tarihi giysilerin korunarak saklanması ve sergilenmesi için uygun çevresel koşulların sağlanmasının önemini vurgulamaktadır. Çünkü giysilerin saklandığı veya sergilendiği ortamların çevresel koşulları, eserlerin zarar görmesinde önemli bir etkendir. Ayrıca, insan faktörü de giysiler üzerinde olumsuz etkiler yaratmaktadır.
Çalışma kapsamında, 20. yüzyıla ait özel bir koleksiyonda yer alan 50’ye yakın kadın giysi örneğinden seçilen 3 eser incelenmiştir. Geleneksel kadın giysi örneklerinin incelenme amacı, bu eserlerin doğal malzemelerle üretilmelerinden kaynaklanan olumsuz çevresel faktörlerden, nasıl etkilendiklerini tespit etmektir. Bu şekilde, kadın giysilerinin saklandığı koşulların elverişsizliği ve olumsuz faktörlerin eserler üzerindeki tahribatıyla birlikte, özellikle insan faktörünün etkisinin de önemli olduğu görülmektedir. Zira, ülkemizde evlerde elverişsiz koşullarda konservasyon bilgisine sahip olmayan kişiler tarafından saklanan birçok kültürel değerin olduğu düşünüldüğünde, koruyucu konservasyon bilgilerinin paylaşılması ve görsel verilerle desteklenmesi önemli bir hedeftir. Ayrıca, günümüze kadar ulaşabilen tarihi giysilerin daha fazla yıpranmaması için gerekli yöntemler, gelişen teknolojik bilgilerden faydalanılarak eserler incelenmiştir. Bu bağlamda, tekstillerin ömürlerini uzatmaya yönelik önemli bilgilerin gelecek nesillere aktarılması hedeflenmiştir. Ancak, tarihi giysilerin korunması için uygulanan koruyucu yöntemlere dair sınırlı sayıda bilimsel çalışma bulunmaktadır. Bu nedenle, çalışmanın literatüre özgün bir katkı sağlaması hedeflenmiştir. Ayrıca kültürel varlıklarımızın gelecek kuşaklara aktarılmasını güvence altına almak adına koruyucu konservasyon yöntemlerinin daha geniş bir perspektifte ele alınması gerektiği vurgulanmıştır.
De novo transcriptomic analysis of Doum Palm (Hyphaene compressa) revealed an insight into its potential drought tolerance
Authors: Borlay Allen Johnny , Mweu Cecilia Mbithe , Nyanjom Steven Ger , Omolo Kevin Mbogo , Naitchede Labode Hospice Stevenson 
Published: March 2024

Background
Doum palms (Hyphaene compressa) perform a crucial starring role in the lives of Kenya’s arid and semi-arid people for empowerment and sustenance. Despite the crop’s potential for economic gain, there is a lack of genetic resources and detailed information about its domestication at the molecular level. Given the doum palm’s vast potential as a widely distributed plant in semi-arid and arid climates and a source of many applications, coupled with the current changing climate scenario, it is essential to understand the molecular processes that provide drought resistance to this plant.

Results
Assembly of the first transcriptome of doum palms subjected to water stress generated about 39.97 Gb of RNA-Seq data. The assembled transcriptome revealed 193,167 unigenes with an average length of 1655 bp, with 128,708 (66.63%) successfully annotated in seven public databases. Unigenes exhibited significant differentially expressed genes (DEGs) in well-watered and stressed-treated plants, with 45071 and 42457 accounting for up-regulated and down-regulated DEGs, respectively. GO term, KEGG, and KOG analysis showed that DEGs were functionally enriched cellular processes, metabolic processes, cellular and catalytic activity, metabolism, genetic information processing, signal transduction mechanisms, and posttranslational modification pathways. Transcription factors (TF), such as the MYB, WRKY, NAC family, FAR1, B3, bHLH, and bZIP, were the prominent TF families identified as doum palm DEGs encoding drought stress tolerance.

Conclusions
This study provides a complete understanding of DEGs involved in drought stress at the transcriptome level in doum palms. This research is, therefore, the foundation for the characterization of potential genes, leading to a clear understanding of its drought stress responses and providing resources for improved genetic modification.
Comparative study between biliary covered self-expandable metal stent and conventional endoscopic bile drainage treatment in endoscopic retrograde cholangiopancreatography-related Stapfer type II retroperitoneal perforations
Authors: Heo Jun , Jung Min Kyu , Lee Jieun , Lee Dong wook , Cho Chang Min , Cha Jung Guen 
Published: March 2024

Background
Perforation is one of the most serious complications of endoscopic retrograde cholangiopancreatography (ERCP). Conventional nonsurgical endoscopic treatments including intravenous antibiotic administration and plastic endoscopic biliary drainage are generally approved for the treatment of ERCP-related Stapfer type II perforation (perivaterian type). Biliary covered metal stent placement has recently been reported to have favorable outcomes in ERCP-related Stapfer type II perforations. We aimed to compare the outcomes of conventional endoscopic bile drainage and biliary covered self-expandable metal stent (SEMS) insertion in patients with Stapfer type II perforation.

Methods
Medical records of patients who underwent ERCP at Kyungpook National University Hospital in Daegu from 2011 to 2022 were retrospectively reviewed.

Results
A total of 8,402 ERCP procedures were performed in our hospital. Sixty-six ERCP-related perforations (0.78%) were identified. Among them, 37 patients (56.1%) who had Stapfer type II perforations were enrolled. Thirteen and twenty-four patients received biliary covered SEMS insertion and conventional endoscopic bile drainage treatments, respectively. No significant differences were observed in the clinical success rate (92.3% vs. 91.7%, p = 1.000), hospital stay (9.46 ± 5.97 vs. 13.9 ± 13.2 days, p = 0.258), and post-ERCP–related fasting time (5.4 ± 3.4 vs 4.3 ± 3.0 days, p = 0.305). Complications including bleeding, post-ERCP pancreatitis, fever, and death were not significantly different between the two groups. The conventional endoscopic bile drainage group took less time for ERCP than the SEMS group (11.5 ± 5.2 vs. 18.5 ± 11.2 min, p = 0.013).

Conclusions
Compared with the conventional endoscopic bile drainage treatment method, biliary covered SEMS did not improve patient outcomes in ERCP-related Stapfer type II perforations.
One-Year Comparative Effectiveness of Upadacitinib vs Tofacitinib for Ulcerative Colitis: A Multicenter Cohort Study
Authors: Dalal Rahul S. , Kallumkal Govind , Cabral Heidy J. , Barnes Edward L. , Allegretti Jessica R. 
Published: March 2024

INTRODUCTION:
The comparative effectiveness of upadacitinib and tofacitinib for ulcerative colitis (UC) is poorly understood.

METHODS:
In this retrospective cohort study, we compared steroid-free clinical remission (SFCR) and endoscopic response/remission at 52 weeks among adults initiating upadacitinib or tofacitinib for UC.

RESULTS:
A total of 155 patients initiated upadacitinib (n = 81; 30% prior tofacitinib exposure) or tofacitinib (n = 74; 0% prior upadacitinib exposure). After inverse probability of treatment-weighted logistic regression, upadacitinib was associated with significantly higher odds of SFCR (odds ratio 3.01, 95% confidence interval 1.39–6.55) vs tofacitinib. There were no differences for endoscopic response/remission.

DISCUSSION:
Upadacitinib was more effective at achieving SFCR in UC at 52 weeks vs tofacitinib.
Assessment of sperm acrosome status, malondialdehyde and aspartate aminotransferase enzyme concentration of frozen semen from Limousin and Simmental bulls in different commercial diluents
Authors: Tahar Muhammad Agus , Komariah Komariah , Nuraini Henny , Maulana Tulus , Gunawan Muhammad , Arifiantini R Iis 
Published: March 2024

Sperm cryopreservation is the process of preserving sperm cells at low temperatures, so that its frozen semen can be used in the future. The quality of the frozen sperm is affected by the diluent. The objective of this study was to compare the effects of commercial diluents on acrosome status, malondialdehyde (MDA) and aspartate aminotransferase (AspAT) enzyme concentration of thawed Limousin and Simmental bull semen. Semen was collected twice weekly using an artificial vagina. The fresh semen processed into frozen semen hadÂ sperm motility of 70%. The one-step procedure was used for the dilution methods. AndromedÂ®, OptixcellÂ® and SteridylÂ® were used as diluents. Data were analyzed by analysis of variance (ANOVA) followed by Tukey HSD 5% confidence interval. The result showed no interaction (P0.05) between two factors on acrosome status. The sperm acrosome damage of Simmental in SteridylÂ® was significantly lower than others (P0.05), although all diluents showed low sperm acrosome damage. Also, no interaction between the type of diluent and breed on MDA and AspAT enzyme concentrations was detected (P0.05). The results suggest that three commercial diluents have equal efficacy in protecting acrosome status and maintaining MDA and AspAT enzyme concentrations of frozen Limousin and Simmental bull semen. Therefore, all commercial diluents can be an alternative for Limousin and Simmental frozen semen.
Association of DGAT1 Gene Related to Flavor, Odor, Cholesterol, and Mineral in Indonesian Sheep
Authors: Amri Fisma , Harahap Ratna Sholatia , Sumantri Cece , Inounu Ismeth , Depison Depison , Alwi Yun , Gunawan Asep 
Published: March 2024

Diacylglycerol acyltransferase 1 (DGAT1) is a potential candidate gene for improving Indonesian lambâ€™s quality and nutrient value.Â The study aimed to identify the diversity of the DGAT1 gene with SNP g.8539 CT and its relation to Indonesian lamb's flavor and odor, cholesterol, and mineral.Â Total of 254 ten to twelve months old sheep consisted of 20 Javanese fat-tail sheep (JFTS), 107 Javanese thin-tail sheep (JTTS), 10 Garut composite sheep (GCS), 10 Compass agrinak sheep (CAS), 10 Barbados cross sheep (BCS), 20 Garut sheep (GS), 27 Jonggol sheep (JS), and 50 Jambi local sheep (JLS).Â One hundred sheep were used to analyze the association of the DGAT1 gene with flavor and odor content, cholesterol, and mineral.Â The diversity of DGAT1|AluI was analyzed with the PCR-RFLP method.Â The association of the DGAT1 gene with the nutritional value of meat was analyzed using the GLM (General Linear Model) method.Â The results showed that the DGAT gene was polymorphic in JTTS, GS, and JFTS and monomorphic in CAS, BCS, JLS, and GCS.Â CC and CT genotypes were found in JTTS, GS, and JFTS.Â SNP g.8539 CT of DGAT1 gene had a significant association (P0.05) with flavor and odor, 4-Ethyloctanoic Acid (EOA).Â However, the DGAT1 gene had no significant association (P0.05) with cholesterol and mineral.Â The DGAT1 gene might be marker-assisted selection for improving lamb flavor and odor in Indonesian sheep.
Immunity and Behaviour of Lambs Born from Ewes Fed a Flushing Diet Containing EPA and DHA
Authors: Nurlatifah Aeni , Khotijah Lilis , Arifiantini Raden Iis , Maidin Mashitah Sikh , Astuti Dewi Apri , Herdis Herdis 
Published: March 2024

Nutrition can influence lamb survival and the immune status during the neonatal phase until weaning. Â This study aimed to investigate the effect of flushing of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) from Lemuru fish oil in the Ewe's diet on lamb immunity and survival.Â Twenty-eight neonatal lambs were divided into four treatments according to Ewe's diet.Â Four treatments: control concentrate (P1), flushing concentrate withÂ 6% palm oil (P2), flushing concentrate with 3% lemuru oil and 3% palm oil (P3), and flushing concentrate with 6% lemuru oil (P4).Â The Ewe were fed Napier grass and concentrated in a 30:70% ratio based on dry matter.Â Ewe and their lambs remained together until weaning at about two months of age.Â The parameter observed in ewes was colostrum Immunoglobulin G (IgG). Â The parameters in the Lamb are blood Ig G, neonatal behavior of the Lamb, physiological response, and hematology of the Lamb at birth and weaning.Â The results showed that feeding P4, P3, and P2 to the Ewe resulted in a shorter latency to stand-in lamb (P0.05).Â P1 has higher leukocytes (P0.05) during weaning than P2 and P3.Â P1 has the same leukocyte as P4.Â Treatment has a non-significant effect (P0.05) on Ig G and physiological response.Â In conclusion, administering 6% Lemuru oil containing EPA and DHA twice can shorten the latency to stand in newborn lambs.