bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anais VII Workshop de Pós-Graduação em Saúde Coletiva em Odontologia, V Encontro de Odontologia em Saúde Coletiva e Bioética, Encontro de Egressos do Programa de Pós-Graduação Saúde Coletiva em Odontologia - 30 Anos
Authors: Saliba Tânia Adas , Moimaz Suzely Adas Saliba , Martins Ronald Jefferson , Custódio Lia Borges de Mattos , Chiba Fernando Yamamoto 
Published: March 2024

Editorial
Nos dias 3 a 5 de agosto de 2023 foi realizado, com muito sucesso, o “VII Workshop de Pós-graduação em Saúde Coletiva em Odontologia e V Encontro de Odontologia em Saúde Coletiva e Bioética”, na Unesp - Faculdade de Odontologia de Araçatuba - FOA. Nesta sétima edição do evento foram comemorados os 30 anos do Programa de Pós-Graduação em Saúde Coletiva em Odontologia e o cinquentenário da fluoretação das águas de abastecimento público do município de Araçatuba, com homenagens à Profª. Titular Dra. Nemre Adas Saliba, pela criação do Programa de Pós-graduação e ao Profº. Titular Dr. Orlando Saliba, pela implantação da fluoretação no município. Compuseram a mesa de abertura representantes das três esferas do governo, a Consultora Técnica da Coordenação Geral de Saúde Bucal do Ministério da Saúde, Dra Sandra Cartaxo, a Coordenadora Estadual de Saúde Bucal de São Paulo, Dra Maria Fernanda Tricoli; a Secretária de Saúde, Carmem Guariente, representando também o prefeito de Araçatuba Dilador Borges; o vereador Antônio Edwaldo Dunga Costa, da Câmara Legislativa Municipal, Dom Sergio Krzwy, Bispo Diocesano de Araçatuba, a homenageada Profa Titular Nemre Adas Saliba, o Diretor da FOA, Prof. Alberto Carlos Botazzo Delbem e a Coordenadora do Programa de Pós-graduação, Profa. Tânia Adas Saliba. O Workshop reuniu 277 participantes, entre pesquisadores, docentes, discentes, e gestores do serviço público de 90 municípios. Foram apresentados 100 trabalhos científicos sobre temas variados, além da realização de conferências, mesas redondas e cursos.
Comissão Organizadora
VII Workshop de Pós-Graduação em Saúde Coletiva em Odontologia, V Encontro de Odontologia em Saúde Coletiva e Bioética, Encontro de Egressos do Programa de Pós-Graduação Saúde Coletiva em Odontologia - 30 Anos
Adsorption’s regularities of radionuclides on adsorbents from solutions
Authors: Mammadov Khagani Farzulla 
Published: March 2024

The object of research: The object of research is the uranium isotopes were found in the soil of the locations of numerous thermal and cold springs in the Kalbajar region of Azerbaijan in the same proportions as in natural uranium deposits.
Investigated problem: Uranium isotopes were transferred from soil samples to solutions. İnvestigated problem of scientific work is study of regularities of adsorption of uranium isotopes from solutions on the surfaces of various adsorbents.
The main scientific results: It is defined high adsorption properties of DOWEX HCR granular elastomer, activated carbon and expanded clay on the result of researches. The activation’s energy of desorption of uranium isotopes from the surface of adsorbents were determined. Relatively low values (22.1–26.3 kJ/mol) of the activation’s energy of desorption of uranium isotopes from the surface of adsorbents indicate the absence of the chemical nature of sorption and the presence of only weak van der Waals forces between the absorbed isotopes and the surface of the adsorbents.
The area of practical use of the research results: The regularities of adsorption of uran isotopes on adsorbent masses from aqueous solutions can be used as an original cleaning method of the drain water of the physical stage of crude oil refining or other radiochemical processes to the norms for waste water.
Innovative technological product: It was determined based on the research, that the concentration of radon in the waters of most springs of the “Istisu” deposit is below the regulatory permissible value (60 Bq/l), which indicates the suitability of these spring waters for use in medical treatment procedures.
Scope of the innovative technological product: It is planned to resume (prevented more than 40 years ago due to global regional problems) the production of the original trademark – “Istisu” medicinal water, with the concentration of radon below the standard value. Considering the two-fold decrease in radon concentration in water over four days, the waters of the individual sources examined, with a 100-fold high radon content, after a certain time (several months) can also be used for use in medical procedures, which allows their transportation to large distances
Series of rare cases of breast tumour: 8-year review at mankweng Breast Oncology clinic, Limpopo, South Africa
Authors: Bhuiyan Mirza M. Z. U. 
Published: March 2024

Breast cancer remains the most common cancer in many parts of the world, particularly for women. In March 2015, a Breast Oncology clinic for breast cancer patients was established at Mankweng Hospital. Invasive ductal carcinoma is the most common (87 %) tumour found in Limpopo, and occasionally, another rare tumour of the breast is presented in the Breast Oncology clinic.
The aim: The main objective is to share the experience of a rare tumour of the breast came across over the past 8 years since the establishment of the Breast Oncology clinic.
Material and Method: Series of rare case reports of Breast tumours and literature review from the Mankweng Breast Oncology Clinic.
Result: Rare tumour encountered in Breast Oncology clinic: adenomyoepithelioma, micro-papillary carcinoma of the breast, primary malignant melanoma of the breast, primary non-Hodgkin's lymphoma of the bilateral breast, advanced breast cancer in a case of Down's syndrome, primary neuroendocrine invasive breast carcinoma, sarcoma of the breast.
Conclusions: Most of these rare cases are presented to the Breast Oncology clinic in the advanced stage. Breast cancer awareness campaign is highly important for women in Limpopo, particularly when attending primary health care for any other conditions.
Procesos de descomposición de cerdos desmembrados (Sus scrofa domestica) dentro de sacos plásticos en Santa Marta, Colombia
Authors: Miranda Zamora Jacinto , Anaya Escalante Miguel , Valverde Castro Cesar 
Published: March 2024

La tafonomía forense hace uso de las técnicas de antropología y arqueología en la investigación de los factores y procesos que afectan los restos de un individuo. Además, se apoya en disciplinas como la entomología forense ―el estudio de los insectos asociados a un cuerpo muerto― para determinar el intervalo post mortem (IPM). En esta investigación se documentó el proceso de descomposición de cuatro cadáveres de cerdos (Sus scrofa domestica) en un fragmento de bosque seco tropical ubicado en la Universidad del Magdalena. Tres de ellos fueron desmembrados y colocados en sacos plásticos de manera individual y aleatoria, y uno, sin alterar, se dejó al aire libre. El muestreo se realizó diariamente durante 15 días, cada cinco horas, registrando las temperaturas corporal y ambiental y la humedad relativa del lugar. Se recolectaron insectos con redes entomológicas y se almacenaron en frascos completamente rotulados con alcohol etílico al 70 %. Al analizar las muestras se obtuvo la cronosecuencia de los insectos de importancia forense en diferentes condiciones ambientales, documentando los tiempos y los cambios en las fases de descomposición para determinar el IPM en cada caso. Se observó que la descomposición de las partes de los cerdos contenidas en sacos fue más rápida que la del cerdo control, a pesar de que este último estuvo expuesto al aire libre, facilitando el acceso de los insectos. Se concluye que el proceso de descomposición de un cadáver varía según factores ambientales, climáticos, agentes físicos, causas de muerte y alteraciones post mortem. Esta información es importante a la hora de esclarecer investigaciones medicolegales ya que ayuda a establecer el IPM en cuerpos encontrados en lugares y condiciones similares.
SGPocket: A New Graph Convolutional Neural Network for
Ligand-protein Binding Site Prediction
Authors: Crampon Kevin , Bourrasset Cedric , Baud Stephanie , Steffenel Luiz Angelo 
Published: March 2024

Background:
Drug research is a long process, taking more than 10 years and
requiring considerable financial resources. Therefore, researchers and industrials aim to
reduce time and cost. Thus, they use computational simulations like molecular docking
to explore huge databases of compounds and extract the most promising ones for further
tests. Structure-based molecular docking is a complex process mixing surface exploration and energy computation to find the minimal free energy of binding corresponding
to the best interaction location.

Objective:
Our work is developed in the ligand-protein context, where ligands are small
compounds like drugs. In most cases, no information is known about where on the protein surface the ligand will bind. Thus, the whole protein surface must be explored,
which takes a huge amount of time.

Methods:
We have developed SGPocket (meaning Spherical Graph Pocket), a binding
site prediction method. Our method allows us to reduce the explored protein surface using deep learning without any information about a ligand. SGPocket uses the spherical
graph convolutional operator working on a spherical relative positioning of amino acids
in the protein. Then, a final step of clustering extracts the binding sites.

Results:
Tested and compared (with well-known binding site prediction methods) on a
hand-made dataset, our method performed well and can reduce the docking computing
time.

Conclusion:
Thus, SGPocket allows the reduction of the exploration surface in the
molecular docking process by restricting the simulation only to the site(s) predicted to
be interesting.
Altitude effect on Propofol Pharmacokinetics in Rats
Authors: Li Lijun , Wang Xuejun , Wang Sheng , Wen Li , Zhang Haopeng 
Published: March 2024

Background:
Propofol is an intravenous agent for clinical anesthesia. As the influence of the hypobaric-
hypoxic environment (Qinghai-Tibetan region, altitude: 2800-4300 m, PaO2: 15.1-12.4 kPa) on the
metabolism of Propofol is complex, the research results on the metabolic characteristics of Propofol in high-
-altitude areas remain unclear. This study aimed to investigate the pharmacokinetic characteristics of Propofol
in a high-altitude hypoxic environment using animal experiments.

Methods:
Rats were randomly divided into three groups: high-altitude, medium-altitude, and plain groups.
The time of disappearance and recovery of the rat righting reflex was recorded as the time of anesthesia induction
and awakening, respectively. The plasma concentration of Propofol was determined by gas chromatography-
mass spectrometry. A pharmacokinetic analysis software was used to analyze the blood-drug concentrations
and obtain the pharmacokinetic parameters.

Results:
We observed that when Propofol anesthetizes rats, the anesthesia induction time was shortened, and
the recovery time was prolonged with increased altitude. Compared with the plain group, the clearance of
Propofol decreased, whereas the half-life, area under the concentration-time curve, peak plasma concentration,
and average residence time extension increased.

Conclusion:
The pharmacokinetic characteristics of Propofol are significantly altered in high-altitude hypoxic
environments.
Predicting the Efficacy of Novel Synthetic Compounds in the Treatment of
Osteosarcoma via Anti-Receptor Activator of Nuclear Factor-κB Ligand
(RANKL)/Receptor Activator of Nuclear Factor-κB (RANK) Targets
Authors: Zhang Wenhua , Xu Siping , Liu Peng , Li Xusheng , Yu Xinyuan , Kang Bing 
Published: March 2024

Background:
Osteosarcoma (OS) currently demonstrates a rising incidence, ranking as
the predominant primary malignant tumor in the adolescent demographic. Notwithstanding this
trend, the pharmaceutical landscape lacks therapeutic agents that deliver satisfactory efficacy
against OS.

Objective:
This study aimed to authenticate the outcomes of prior research employing the HM and
GEP algorithms, endeavoring to expedite the formulation of efficacious therapeutics for osteosarcoma.

Methods:
A robust quantitative constitutive relationship model was engineered to prognosticate the
IC50 values of innovative synthetic compounds, harnessing the power of gene expression programming.
A total of 39 natural products underwent optimization via heuristic methodologies within the
CODESSA software, resulting in the establishment of a linear model. Subsequent to this phase, a
mere quintet of descriptors was curated for the generation of non-linear models through gene expression
programming.

Results:
The squared correlation coefficients and s2 values derived from the heuristics stood at
0.5516 and 0.0195, respectively. Gene expression programming yielded squared correlation coefficients
and mean square errors for the training set at 0.78 and 0.0085, respectively. For the test set,
these values were determined to be 0.71 and 0.0121, respectively. The s2 of the heuristics for the
training set was discerned to be 0.0085.

Conclusion:
The analytic scrutiny of both algorithms underscores their commendable reliability in
forecasting the efficacy of nascent compounds. A juxtaposition based on correlation coefficients
elucidates that the GEP algorithm exhibits superior predictive prowess relative to the HM algorithm
for novel synthetic compounds.
Preliminary Test of Candidate Rapid Diagnostic Test for the Detection of 38 kDa Mycobacterium Tuberculosis Antigen in Saliva
Authors: Mardining Raras Tri Yudani , Rahmadani Nabila , Arthamin Maimun Zulhaidah , Rizki Muhammad 
Published: March 2024

Background and Objectives
Identifying tuberculosis (TB) in pediatric cases is a major challenge in developing countries, as children have problems with expelling sputum, making specific diagnostics crucial. The objective of the study was to develop a rapid test using polyclonal antibodies to detect antigen 38kDa from Mycobacterium tuberculosis in the saliva of TB patients.

Materials and Methods
The recombinant protein Ag38 was purified using the Ni-NTA purification kit. Polyclonal antibodies were generated in BALB-c mice using 50 µg/ml of purified Ag38 recombinant protein. A Lateral Flow Assay (LFA) was constructed, employing 5 mg/mL colloidal gold-labelled polyclonal antibody anti-Ag38 in the test line to capture the conjugates, while goat anti-mouse IgG was used in the control line. The LFA was tested in 5 TB patients and 7 healthy person served as negative control .

Results
The recombinant protein achieved 95% purity. The rapid test kit, with a detection limit of 5.3 µg/mL, successfully identified Ag38 protein in TB patient saliva (positive control) and not in healthy human serum (negative control). While reproducibility was confirmed for TB patients, results were inconsistent for healthy individuals.

Conclusion
The Lateral Flow Assay using polyclonal antibody Ag38 displays promise in detecting M tuberculosis antigen in the saliva of TB patients. Further validation with more TB patient saliva samples is needed to determine LFA sensitivity and specificity.
A Study of Machine Learning Algorithms Performance Analysis in Disease Classification
Authors: B Jai Kumar , R Mohanasundaram 
Published: March 2024

Background
Because there are no symptoms, it might be difficult to detect CKD in its early stages. One of the main causes of CKD is diabetes mellitus (DM), and early detection of the condition can assist individuals in obtaining prompt treatment. Because this illness has no early signs and is only discovered after the kidneys have gone through 25% damage, early-stage prediction is not very likely. This is the key factor driving the need for early CKD prediction.

Objective
The objective of the paper is to find the best-performing learning algorithms that can be used to predict chronic kidney disease (CKD) at an earlier stage.

Methods
This research aimed to compare different machine learning algorithms used in different disease predictions by various researchers. In this comparative study, machine learning algorithms like Logistic Regression, K-Nearest Neighbor, Decision Tree, Support Vector Machine, Artificial Neural Network, Random Forest, Composite Hypercube on Iterated Random Projection, Naïve Bayes, J48, Ensembling, Multi-Layer Perceptron, Deep Neural Network, Autoencoder, and Long Short-Term Memory are used in disease classification.

Results
Each classification model is well tested in a different dataset, and out of these models, RF, DNN, and NB classification techniques give better performance in Diabetes and CKD prediction.

Conclusion
The RF, DNN, and NB classification algorithms worked well and achieved 100% accuracy in predicting diseases.
Proportion of Streptococcus mutans, Streptococcus sanguinis, and Candida albicans in Early Childhood Caries: Evaluation by qPCR
Authors: Agustin Tri Putriany , Sutadi Heriandi , Bachtiar Boy M , Rizal Mochamad Fahlevi 
Published: March 2024

Background
Early childhood caries (ECC) is one of the most common diseases in children. It is associated with oral microbiome dysbiosis, characterized by a reduced beneficial oral microbiome and an increased pathogenic oral microbiome.

Objective
This study aims to detect and quantify S. mutans, S. sanguinis, and C. albicans in dental plaque samples from caries-free and ECC groups of children using the quantitative polymerase chain reaction (qPCR).

Materials and Methods
Supragingival plaque samples were collected from 30 children aged 2 to 5 divided into three groups: 15 caries-free children, 7 ECC, and 8 S-ECC. The abundance of microorganisms was determined by qPCR. The obtained data were analyzed using one-way ANOVA (post hoc Bonferroni) and the Pearson and Spearman correlation tests.

Results
The S-ECC group had a higher proportion of S. mutans and C. albicans. The proportion of S. sanguinis was higher in the ECC and had a positive correlation (P < 0.05) with S. mutans in this same group.

Conclusion
The proportion of S. mutans, S. sanguinis, and C. albicans differed between the caries-free, ECC, and S-ECC groups, and they correlated with each other in the occurrence of ECC.
Efficacy of Smartphone-based Fundus Photo in Vision Threatening Diabetic Retinopathy Screening: Developing Country Perspective
Authors: Nursalamah Mia , Karfiati Feti , Ratnaningsih Nina , Widihastha Sri Hudaya 
Published: March 2024

Background
Vision-threatening diabetic retinopathy (VTDR) is a microvascular retinal complication caused by diabetes mellitus, which may lead to blindness if left untreated. One of the most effective methods to prevent diabetic-related ocular complications is through diabetic retinopathy (DR) screening. The community rarely carries out diabetic retinopathy-related eye examinations because using non-portable fundus photographs as its gold standard is costly and impracticable. This study aimed to determine the accuracy of smartphone-based fundus photographs as a practical and affordable tool for VTDR screening in developing countries.

Methods
This cross-sectional study used a consecutive technique at Cicendo National Eye Hospital, Indonesia. Patients with diabetes mellitus aged ≥20 years were evaluated for two-field mydriatic fundus photos using a non-portable fundus photo and a smartphone- based fundus photo utilizing the i-Spot fundus adapter. Results were analyzed to determine diagnostic test parameters.

Results
Two hundred and nineteen two-field mydriatic fundus photos were obtained from 139 patients. Smartphone-based fundus photography demonstrated a sensitivity of 98.4% (CI 96.6–100%), a specificity of 87.1% (CI 75.3–98.9%), a positive predictive value of 97.9% (CI 95.9–99.9%), a negative predictive value of 90.0% (CI 79.3–100%), and an accuracy of 96.8% (CI 94.5–99.8%).

Conclusion
The use of smartphone-captured fundus images proves to be a reliable screening method for VTDR. This tool has the potential to effectively screen the population, helping prevent future visual loss attributed to the disease.
Unraveling Skin Carcinoma: A Comprehensive Examination of Diagnosis, Treatment Strategies, and Emerging Therapeutic Avenues in Skin Cancer
Management
Authors: Bhadouria Namrata , Alam Aftab , Kaur Awaneet 
Published: March 2024

Abstract:
Cancer that begins in the skin is by far the most common kind of skin cancer found everywhere
in the globe. It is further subdivided into groups, such as basal cell carcinoma and cutaneous
squamous cell carcinoma, in addition to other, less common types of skin cancer. In this article,
the diagnostic aspects that need to be taken into consideration when utilizing these new guidelines,
go over the essential features of cutaneous SCC, conduct an analysis of recent changes in the category
of cutaneous SCC, and speak about recent advancements in the categorization of cutaneous
SCC. Over the course of the past decade, photodynamic therapy has developed into a potentially effective
treatment for a variety of solid tumors that may be found in people. The combination of metallic
nanoparticles and phytoconstituents as a therapy for skin cancer has the potential to be more
successful than each treatment used independently. In this article, the various treatment modalities
for skin cancer were examined. This included excision surgery, Mohs surgery, radiation therapy,
and immunotherapy. These were then followed by targeted therapy or immunotherapy, in addition
to surgery, radiation, or photodynamic therapy. Since excision surgery is the most typical procedure
used to eradicate skin cancer, we concentrate on it in particular.
A Study on the Steady and Dynamic Performance of Dry Gas Seals with
Combined Superelliptical Grooves and Holes on the End Face
Authors: Li Yushi , Chen Yuan , Li Yuntang , Li Xiaolu , Wang Bingqing , Jin Jie 
Published: March 2024

Background:
Enhancing the stability and leakage control of Dry Gas Seals (DGS) under
high parameters has been a crucial research focus. The design of end-face groove structures and
surface texture shapes has been an essential aspect of DGS studies aimed at improving performance.

Objective:
The proposed end-face gas seal utilizes superelliptical grooves and holes to improve its
performance, aiming to obtain a patent. The use of superelliptical curves allows for a more precise
and efficient geometric representation, resulting in a better sealing effect.

Methods:
A theoretical analysis model for the steady and dynamic behavior of the seal is established
using the lubrication theory and perturbation methods. The study investigates the distribution
patterns of gas film pressure on the sealing end-face and gas flow characteristics within the
film. This approach provides a new perspective for understanding seal performance and offers a
theoretical basis for optimizing seal design.

Results:
The results indicate that the combined end-face structure with grooves and holes ensures
good sealing stability and effectively enhances leakage control performance. By optimizing the design
of the superelliptical groove and holes on the end face, the performance of DGS can be significantly
improved.

Conclusion:
Within the parameter range studied, better steady-state performance is achieved for
θ=40~80°, v=1.3~1.4, u=1~2, β=0.6~0.7, and λ=1.0~1.5. In addition, better dynamic performance
is observed for θ=80~120°, v=1.1~1.2, u=2~3, β=0.9~1.0, and λ=2.0~2.5.