bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Qualitative Content Analysis to Investigate 21st Century Skills in Learning Outcomes of High School Biology Course Curriculum
Authors: Kasap Melek Yaman , Acar Bilge , Kasap Suat 
Published: March 2024

21st century skills combine accessing information and employing it in solving problems faced in daily life, employing advanced thinking skills, working with others in harmony, effectively using technology, and being aware of global and local economic and social events. Parallel to recent educational trends in the world and in accordance with the 21st century skills, curricula in many countries have gone through substantial changes. There is an obvious need to determine how compatible learning outcomes of course curricula are with the 21st century skills. The objective of this study is to analyze learning outcomes of high school biology course curriculum within the framework of 21st century skills. The data were collected through document analysis and analyzed by the content analysis methods. In the study, each learning outcome and explanations in the biology course curriculum was analyzed in terms of their compatibility within the framework of the basic 21st century skills and related sub-skills. Results have shown that learning outcomes of the biology course curriculum are in accordance with the 21st century skills, but the distribution of the 21st century skills show different distribution (learning and innovation skills, 59%; media and technology skills, 23%; life and career skills, 18%), within the curriculum. There is no study in the literature that covers all grade levels and 21st century skills for the biology courses at the high school. This work intends to fill this gap.

Received: 2 December 2023 / Accepted: 16 February 2024 / Published: 5 March 2024
The Effectiveness of The Concept Mapping Strategy in Developing of Digital Concepts Among Students at Prince Sattam bin Abdulaziz University
Authors: Mohammad Alharbi Huda Saad 
Published: March 2024

This study aimed to explore the efficacy of concept mapping in enhancing digital concept development among female undergraduate students enrolled in a computer skills course. A total of 70 participants were randomly assigned to either an experimental group instructed through concept mapping, or a control group taught using traditional methods. The experimental group, utilizing concept mapping, significantly outperformed the control group in posttest assessments of digital concepts (p < 0.05). These findings suggest that concept mapping can effectively boost digital literacy within computer skills education. Recommendations encompass the integration of concept mapping in computer and digital skills courses, offering training to both educators and students on the use of concept mapping, and the active incorporation of this strategy across educational levels. In summary, this investigation underscores the significance of concept mapping as a potent instructional approach for cultivating fundamental digital competencies.

Received: 19 December 2023 / Accepted: 16 February 2024 / Published: 5 March 2024
Dermoscopy Evaluation of Erythema Dyschromicum Perstans Treated with Combination of Topical Steroid and Narrowband-Ultraviolet B: A Case Report
Authors: Triani Aisha , Satya Wydya Yenny  
Published: March 2024

Background: Erythema dyschromicum perstans (EDP), also known as ashy dermatosis, is an uncommon, acquired, and persistent skin condition identified by development of hyperpigmented macules of varying sizes on the trunk, face, and extremities. It exact cause is unknown, and there is ongoing debate surrounding its treatment. Dermoscopic assessments may prove beneficial in evaluating the effectiveness of therapeutic interventions.
Case presentation: We present a case of a 20-year-old woman with numerous hyperpigmented macules of brown to slate-grey on her upper trunk, stomach, back, and extremities over the past three years. The patient reported no symptoms such as itching, numbness, or pain. Upon physical examination, mild anemia but otherwise healthy. On physical examination there are multiple brown-grey patches with reddish borders of varying sizes distributed across the body, with unaffected mucosa, scalp, palms, soles, and nails. Dermoscopic examination unveiled a widespread distribution of brown to grey backgrounds with a pinkish homogeneous appearance. Histopathological examination suitable for erythema dyschromicum perstans. The patient received a diagnosis of erythema dyschromicum perstans and underwent treatment involving a combination of topical steroids and Nb-UVB administered three times weekly for a duration of 8 weeks.
Conclusion: This condition presents a cosmetic concern throughout the patient's lifetime and significantly affects their quality of life. After 8 weeks of the combination of topical steroids and Nb-UVB, there was a improvement of erythema and lesion appear lighter. This observation suggests that a treatment with a consistently favorable outcome has not been identified and necessitates further investigation.
الصحافة المكتوبة والإلكترونية " الواقع والطموح"
Authors: سالم بوجبيرة حامد 
Published: March 2024

هذا البحث كما يتبادر للمطلع للوهلة الأولى، إنه قد يعنى بصحافة معينة، أو بلون معين من الصحافة، أو بصحافة سين وجيم من الدول، لكنه وللحقيقة قصد به أبعد من ذلك واشمل الا وهو إثارة تلك المخاوف الجادة والقلق المتزايد بشأن مستقبل الصحافة المكتوبة على ضوء هذا التطور المأهول لوسائل الاتصال والإعلام وظهور ما يسمى "بالإعلام الجديد" نسبتاً إلى التجاوز أو التلاقح بين "المكتوب والمقروء و المسطحات الالكترونية "التي صارت هي السائدة في عالم اليوم، ومعها تراجعت الصحافة الورقية بشكل ملفت غير محسوب وتهاوت حصونها التقليدية بدون أي سابق إنذار.
وفى وقت يعلو فيه من هنا صوت المرئي عما عداه وتتقدم فيه لوحة الأزرار على التصفح للورق وتلوث الأنامل بالكربون كما هو العرف التقليدي، يصبح قلق القائمين على الصحافة المكتوبة وبالأخص المتربحين من ورائها أفراداً كانوا أم حكومات ودول في قلق شديد ومتزايد خاصة بعد أن ثبت بأن من أول نتائج "الإعلام الجديد" هو تراجع نسب توزيع الصحافة المكتوبة وتراجع أعداد المطبوع منها يوماً بعد آخر في أعقاب ظهور ما يسمى بالصحافة الإلكترونية، فضلاً عن كون عدداً من هذه الصحف التي لم يكن لها موقع في الفضاء الإلكتروني قد أقفلت أبوابها. من هنا تأتى أهمية هذا البحث في هذا الصدد في محاولة لاستقراء مستقبل الصحافة المكتوبة على ضوء كل هذه التطورات والمتغيرات( (الفار:2006: 208-21
إخراج وتصميم العناصر البنائية التقليدية في الصفحة الرئيسة لمواقع الصحف الإلكترونية الفلسطينية
Authors: محمود سالم ثابت أ. رحمة 
Published: March 2024

بفضل ما يقدمه الإنترنت من تطبيقات حديثة، تسابقت المؤسسات الإعلامية على اختلافها لتوظيف هذا المورد الاتصالي في نشر وتبادل المنتج الإعلامي بأشكاله المختلفة، مما أوجد أنماطًا إعلامية وإعلانية جديدة كان من أبرزها الصحافة الإلكترونية التي حرصت منذ البداية على توظيف هذه التكنولوجيا في تصميم وإخراج مواقعها الإلكترونية بشكل يهدف إلى يُسر التصفح والاستخدام، والذي يعكس بدوره مدى كفاءة الصحيفة في عرض المعلومات وسهولة استدعائها.
وعليه فإن الدراسة الحالية تركز على معرفة الأساليب الإخراجية المستخدمة في إخراج وتصميم العناصر البنائية التقليدية في الصفحة الرئيسة لمواقع الصحف الفلسطينية (الأيام، فلسطين)، والتعرف على أوجه الشبه والاختلاف بينهما باستخدام أسلوب مسح المضمون – تحليل المحتوى – لمدة عشرة أيام لكل صحيفة على حدة، وشملت الدراسة ثلاثة مباحث، على النحو الآتي:
المبحث الأول: الإطار المنهجي للدراسة
المبحث الثاني: الإطار المعرفي للدراسة
المبحث الثالث: عرض نتائج الدراسة التحليلية وتفسيرها والإجابة عن تساؤلات الدراسة وتحقيق أهدافها.
البرامج الليبية الساخرة على اليوتيوب
Authors: عبد اللطيف مفتاح البكاي محمـد 
Published: March 2024

هدفت هذه الدراسة إلى التعرف على البرامج الليبية الساخرة على اليوتيوب وشملت التعرف على الموضوعات التي تناولتها البرامج الساخرة على اليوتيوب ونوعها وأبعادها والكشف عن الأهداف التي تسعى البرامج الساخرة لتحقيقها والأساليب والاستمالات المستخدمة وتحديد المصادر التي تم الاعتماد عليها وأساليب تقديمها وعناصر الجذب والوقوف على الأساليب الفنية المستخدمة في البرامج الساخرة "عينة الدراسة" من حيث (حجم الكادر - زاوية الكاميرا- مكان الإنتاج - الوسائط المتعددة المستخدمة الكشف عن الجهات التي تم انتقادها في البرامج الساخرة على اليوتيوب وأنواع الضيوف - معرفة زمن البرامج الليبية الساخرة على يوتيوب) .
واعتمدت الدراسة المنهج الوصفي مستخدمة أسلوب تحليل المضمون لتحليل حلقات البرامج الليبية الساخرة على قنوات (منلاخير) والتي التي شملت على برنامجي (منلاخير شو- #VLOGS) و(قناة الواو ليبيا) والتي شملت برنامج (المخزن- مستر عوكاكو- شوية مع شيكا) ، و تم إجراء الدراسة التحليلية بعد عمل مسح شامل للبرامج الساخرة المعروضة عبر القناتين والتي بلغ عددها (70) حلقة في الفترة من بداية شهر يناير من العام 2021 وحتى نهاية شهر ديسمبر من ذات العام ، وتوصلت الدراسة إلى عدة نتائج من أهمها : تصدر الموضوعات الاجتماعية التي تناولتها تلك البرامج اللبيبة الساخرة على يوتيوب وسعيها إلى تحقيق أهداف توعويةٍ ذات أبعاد وطنية معتمدة في ذلك على الاستمالات العقلية و اعتماد أسلوب المحاكاة الساخرة كأسلوب نقدي في البرامج الليبية .
Double-nylon purse-string suture in closing postoperative wounds following endoscopic resection of large (≥ 3 cm) gastric submucosal tumors
Authors: Wang Shan-Shan , Ji Meng-Yao , Huang Xu , Li Yan-Xia , Yu Shi-Jie , Zhao Yu , Shen Lei 
Published: March 2024

BACKGROUND
Endoscopic full-thickness resection (EFTR) of gastric submucosal tumors (SMTs) is safe and effective; however, postoperative wound management is equally important. Literature on suturing following EFTR for large (≥ 3 cm) SMTs is scarce and limited.
AIM
To evaluate the efficacy and clinical value of double-nylon purse-string suture in closing postoperative wounds following EFTR of large (≥ 3 cm) SMTs.
METHODS
We retrospectively analyzed the data of 85 patients with gastric SMTs in the fundus of the stomach or in the lesser curvature of the gastric body whose wounds were treated with double-nylon purse-string sutures after successful tumor resection at the Endoscopy Center of Renmin Hospital of Wuhan University. The operative, postoperative, and follow-up conditions of the patients were evaluated.
RESULTS
All tumors were completely resected using EFTR. 36 (42.35%) patients had tumors located in the fundus of the stomach, and 49 (57.65%) had tumors located in the body of the stomach. All patients underwent suturing with double-nylon sutures after EFTR without laparoscopic assistance or further surgical treatment. Postoperative fever and stomach pain were reported in 13 (15.29%) and 14 (16.47%) patients, respectively. No serious adverse events occurred during the intraoperative or postoperative periods. A postoperative review of all patients revealed no residual or recurrent lesions.
CONCLUSION
Double-nylon purse-string sutures can be used to successfully close wounds that cannot be completely closed with a single nylon suture, especially for large (≥ 3 cm) EFTR wounds in SMTs.
Staging liver fibrosis with various diffusion-weighted magnetic resonance imaging models
Authors: Jiang Yan-Li , Li Juan , Zhang Peng-Fei , Fan Feng-Xian , Zou Jie , Yang Pin , Wang Peng-Fei , Wang Shao-Yu , Zhang Jing 
Published: March 2024

BACKGROUND
Diffusion-weighted imaging (DWI) has been developed to stage liver fibrosis. However, its diagnostic performance is inconsistent among studies. Therefore, it is worth studying the diagnostic value of various diffusion models for liver fibrosis in one cohort.
AIM
To evaluate the clinical potential of six diffusion-weighted models in liver fibrosis staging and compare their diagnostic performances.
METHODS
This prospective study enrolled 59 patients suspected of liver disease and scheduled for liver biopsy and 17 healthy participants. All participants underwent multi-b value DWI. The main DWI-derived parameters included Mono-apparent diffusion coefficient (ADC) from mono-exponential DWI, intravoxel incoherent motion model-derived true diffusion coefficient (IVIM-D), diffusion kurtosis imaging-derived apparent diffusivity (DKI-MD), stretched exponential model-derived distributed diffusion coefficient (SEM-DDC), fractional order calculus (FROC) model-derived diffusion coefficient (FROC-D) and FROC model-derived microstructural quantity (FROC-μ), and continuous-time random-walk (CTRW) model-derived anomalous diffusion coefficient (CTRW-D) and CTRW model-derived temporal diffusion heterogeneity index (CTRW-α). The correlations between DWI-derived parameters and fibrosis stages and the parameters’ diagnostic efficacy in detecting significant fibrosis (SF) were assessed and compared.
RESULTS
CTRW-D (r = -0.356), CTRW-α (r = -0.297), DKI-MD (r = -0.297), FROC-D (r = -0.350), FROC-μ (r = -0.321), IVIM-D (r = -0.251), Mono-ADC (r = -0.362), and SEM-DDC (r = -0.263) were significantly correlated with fibrosis stages. The areas under the ROC curves (AUCs) of the combined index of the six models for distinguishing SF (0.697-0.747) were higher than each of the parameters alone (0.524-0.719). The DWI models’ ability to detect SF was similar. The combined index of CTRW model parameters had the highest AUC (0.747).
CONCLUSION
The DWI models were similarly valuable in distinguishing SF in patients with liver disease. The combined index of CTRW parameters had the highest AUC.
Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury
Authors: Jiang Jin-Lian , Zhou Yi-Yang , Zhong Wei-Wei , Luo Lin-Yan , Liu Si-Ying , Xie Xiao-Yu , Mu Mao-Yuan , Jiang Zhi-Gang , Xue Yuan , Zhang Jian , He Yi-Huai 
Published: March 2024

BACKGROUND
Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) plays a crucial role in metabolizing and detoxifying endogenous and exogenous substances. However, its contribution to the progression of liver damage remains unclear.
AIM
To determine the role and mechanism of UGT1A1 in liver damage progression.
METHODS
We investigated the relationship between UGT1A1 expression and liver injury through clinical research. Additionally, the impact and mechanism of UGT1A1 on the progression of liver injury was analyzed through a mouse model study.
RESULTS
Patients with UGT1A1 gene mutations showed varying degrees of liver damage, while patients with acute-on-chronic liver failure (ACLF) exhibited relatively reduced levels of UGT1A1 protein in the liver as compared to patients with chronic hepatitis. This suggests that low UGT1A1 levels may be associated with the progression of liver damage. In mouse models of liver injury induced by carbon tetrachloride (CCl4) and concanavalin A (ConA), the hepatic levels of UGT1A1 protein were found to be increased. In mice with lipopolysaccharide or liver steatosis-mediated liver-injury progression, the hepatic protein levels of UGT1A1 were decreased, which is consistent with the observations in patients with ACLF. UGT1A1 knockout exacerbated CCl4- and ConA-induced liver injury, hepatocyte apoptosis and necroptosis in mice, intensified hepatocyte endoplasmic reticulum (ER) stress and oxidative stress, and disrupted lipid metabolism.
CONCLUSION
UGT1A1 is upregulated as a compensatory response during liver injury, and interference with this upregulation process may worsen liver injury. UGT1A1 reduces ER stress, oxidative stress, and lipid metabolism disorder, thereby mitigating hepatocyte apoptosis and necroptosis.
Segmentation-free Recognition Algorithm Based on Deep Learning for Handwritten Text Image
Authors: Peng Ge 
Published: March 2024

Segmentation-based offline handwritten character recognition algorithms suffered from the segmenting difficulty of interleaving and touching in handwritten manuscripts. To tackle the problem, a segmentation-free recognition algorithm based on deep learning network is proposed in this paper. The network consists of four neural layers, including input layer for image preprocessing, CNNs layer for feature extraction, BDLSTM layer for sequence prediction, and connectionist temporal classification layer for text sequence alignment and classification. Besides, a novel data processing method is performed for data length equalization. Based on this, groups of experiments, based on six typical databases, involved in evaluation indicators of character correct rate, training time cost, storage space cost and testing time cost are carried out. The experimental results show that the proposed algorithm has better performances in accuracy and efficiency than other classical algorithms.
Unveiling Luminous Lyα Emitters at z ≈ 6 through JWST/NIRCam Imaging in the COSMOS Field
Authors: Ning Yuanhang , Cai Zheng , Lin Xiaojing , Zheng Zhen-Ya , Feng Xiaotong , Li Mingyu , Li Qiong , Spinoso Daniele , Wu Yunjing , Zhang Haibin 
Published: March 2024

Abstract
We study a sample of 14 spectroscopically confirmed Lyα emitters (LAEs) in the late era of reionization (at redshift z ≈ 6) based on the JWST/NIRCam imaging data set. These LAEs with high Lyα luminosity of L(Lyα) ∼1042.4–1043.4 erg s−1 have been covered by the (ongoing) COSMOS-Web survey over 0.28 deg2 in four NIRCam bands (F115W, F150W, F277W, and F444W). With JWST/NIRCam imaging, we determine the UV continua with M
UV ranging from −20.5 to −18.5 mag. The UV slopes have a median value of β ≈ −2.35, and the steepest slopes can reach β < −3. Under the excellent spatial resolution of JWST, we identify three objects in the sample as potential merging/interacting systems. The 14 LAEs (and their components) are compact in morphology, residing substantially below the mass–size relation of high-z galaxies. We further investigate their physical properties, including the stellar mass (M
*) and star formation rates (SFRs). Most of the LAEs lie on the SFR–M
* main-sequence relation, while two of them, featured as “little red dots,” likely host active galactic nuclei (AGNs), implying a ∼10% AGN fraction. Moreover, we reveal that a new correlation may exist between Lyα equivalent width and the offset between Lyα and UV emission (Δd
Lyα
), with a median Δd
Lyα
∼ 1 kpc. This could be explained by the Lyα radiative transfer process in both the interstellar medium and circumgalactic medium. The results usher in a new era of detailed analysis on high-z LAEs with the JWST capability.
Antihypertensive activity of spray-dried nanoemulsion containing Asiatic acid-Palm oil in high salt diet-fed rats
Authors: Pradana Aditya Trias , Ritthidej Garnpimol C. , Limprasutr Vudhiporn , Wongtayan Ausana , Lipipun Vimolmas , Iksen  
Published: March 2024

Asiatic acid (AA) is a compound isolated from Centella asiatica, which possesses significant antihypertensive activity. Several studies have shown that its hypertensive activity can be attributed to various mechanisms, such as Angiotensin-Converting-Enzyme (ACE) inhibition in the renin-angiotensin-aldosterone system (RAAS) pathway. Meanwhile, palm oil (PO) is an antioxidant, which has proven to have synergistic effects with the compound by preventing arterial thrombosis and atherosclerosis. Despite these synergistic effects, AA dosage in antihypertensive therapy has been reported to be relatively high compared to the common synthetic drug captopril. Therefore, this study aimed to produce spray-dried powder of nanoemulsion to enhance the solubility of AA, decrease the possibility of oxidation, and increase its activity. Redispersed AA nanoparticles were also successfully obtained during the synthesis process. Several evaluations were carried out, including particle size, particle distribution, zeta potential, cell viability, and antihypertensive activity in rats to ensure the improvement of physicochemical characteristics and activity as antihypertensive agent. The results showed that AA succeeded in forming nanoemulsion with excipients. In addition, it was encapsulated in a maltodextrin carrier, exhibiting good physicochemical characteristics and safety to the Caco-2 cells. The redispersion of the spray-dried powder yielded nanoparticles with a size of 217.4 ± 10.196 nm. The spray-dried nanoemulsion of AA also had faster effect than non-formulated AA (raw powder) in lowering the blood pressure of hypertensive Sprague-Dawley (SD) rats.
Graphical abstract:
Classroom Innovation Using the NCJMM: Preparing Nursing Students for the Next Generation NCLEX
Authors: Sullivan Kelly , Kolcun Kaitlyn , King Tara Spalla 
Published: March 2024

Background:
There is a growing demand for classroom creativity to increase engagement and build clinical judgment skills for nursing students. This article describes the design and implementation of an interactive classroom activity to enhance the development of clinical judgment while simultaneously orienting students to the new NCLEX Next Generation testing model.

Method:
Faculty developed an interactive unfolding case study incorporating the six dimensions of the NCSBN Clinical Judgment Measurement Model. The case study question types were adapted to use an interactive learning platform for first-year nursing students. Students' perceptions of learning, engagement, and clinical judgment were surveyed.

Results:
Student responses regarding the case study implementation indicated this method was effective in maintaining engagement and persistence, as well as promoting nursing decision making.

Conclusion:

The time used for building innovative classroom activities is well spent to meet the objective of enhancing clinical judgment in the next generation of nursing students.

[
J Nurs Educ
. 2024;63(3):188–191.]
A hospital-based cross-sectional study on parental self‑medication among children in a tertiary care hospital in Kolkata
Authors: Paul Kalyan Kumar , Maiti Anindita , Chaudhuri Susmita , Lahiri Mahuya , Chattopadhyay Biswadip 
Published: March 2024

Introduction: Self-medication/self-prescription, the practice of using measures to treat and handle diseases, without consulting appropriate authority, has been significantly inculcated in modern society. Parental self-medication is today a significant paediatric public health problem contributing to global rise of antimicrobial resistance.Objectives: To assess the magnitude and determinants of parental self-medication among children attending a tertiary care hospital in Kolkata. Method: This cross-sectional study was conducted on parents of 105 children attending the paediatric clinic of a tertiary care hospital in Kolkata. Universal sampling was employed. Parents were surveyed by face-to-face interview using a pre-tested semi-structured interview schedule validated by subject experts. Information on pattern, reasons, and perception of parental self-medication were elicited from the schedule. Microsoft Excel and STATA MP16 were used for statistical analysis. Results: Mean ages of the parents and their children were 31.79±5.6 years, and 5.3±2.9 years respectively. Prevalence of parental self-medication was 78.1% (95% CI: 69-85%). Analgesic-antipyretics were the most common type of medicine used during self-medication (77.1%), whereas prior experience in dealing with similar illness was the most common reason (42%) for practising self-medication. Higher educational levelof respondent parent and increased age of child (>3 years) were significantly associated with the practice of self-medication in bivariate analysis.Conclusions: Prevalence of parental self-medication was 78.1%. Analgesic-antipyretics were used during self-medication in 77.1% cases. Prior experience in dealing with similar illness was the reason for practising self-medication in 42% cases. Higher educational level of the respondent parent and increased age of child (>3 years) were significantly associated with the practice of self-medication.