bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect and mechanism of quercetin or quercetin‐containing formulas against COVID‐19: From bench to bedside
Authors: Chen Jhong Yuan , Huang Tsung Rung , Hsu Shih Yun , Huang Ching Chun , Wang Huei Syun , Chang Jung San 
Published: March 2024

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has caused the global coronavirus disease 2019 (COVID‐19) pandemic since 2019. Immunopathogenesis and thromboembolic events are central to its pathogenesis. Quercetin exhibits several beneficial activities against COVID‐19, including antiviral, anti‐inflammatory, immunomodulatory, antioxidative, and antithrombotic effects. Although several reviews have been published, these reviews are incomplete from the viewpoint of translational medicine. The authors comprehensively evaluated the evidence of quercetin against COVID‐19, both basically and clinically, to apply quercetin and/or its derivatives in the future. The authors searched the PubMed, Embase, and the Cochrane Library databases without any restrictions. The search terms included COVID‐19, SARS‐CoV‐2, quercetin, antiviral, anti‐inflammatory, immunomodulatory, thrombosis, embolism, oxidative, and microbiota. The references of relevant articles were also reviewed. All authors independently screened and reviewed the quality of each included manuscript. The Cochrane Risk of Bias Tool, version 2 (RoB 2) was used to assess the quality of the included randomized controlled trials (RCTs). All selected studies were discussed monthly. The effectiveness of quercetin against COVID‐19 is not solid due to methodological flaws in the clinical trials. High‐quality studies are also required for quercetin‐containing traditional Chinese medicines. The low bioavailability and highly variable pharmacokinetics of quercetin hinder its clinical applications. Its positive impact on immunomodulation through reverting dysbiosis of gut microbiota still lacks robust evidence. Quercetin against COVID‐19 does not have tough clinical evidence. Strategies to improve its bioavailability and/or to develop its effective derivatives are needed. Well‐designed RCTs are also crucial to confirm their effectiveness in the future.
Integrating China's carbon capture, utilization, and storage policy for sustainable development: Insights from content analysis
Authors: Feng Lu , Ren Qiuyu , Ioppolo Giuseppe , Liao Wenjie 
Published: March 2024

AbstractInsufficient supporting policies jeopardize the role of carbon capture, utilization, and storage (CCUS) in climate action and energy transition. A few studies have addressed the policy challenges facing CCUS but left policy integration underappreciated. In this article, we analyze the preference for and integration between key elements of China's CCUS policy using policy integration theory and content analysis method that includes a novel three‐dimensional framework. Analysis of 63 CCUS policy documents indicates that China's CCUS policy is not sufficiently comprehensive in including policy implementers and goals, lacks consistency between policy instruments and goals, and is not yet a collaborative system. Finally, we present some implications for addressing the defects in integration of China's CCUS policy: (1) broader incorporation of citizens and non‐governmental organizations, (2) enhanced integration of enterprises, voluntary policy instruments, and economy goal, and (3) enhanced integration of government agencies, compulsory policy instruments, and safety goal.
A DFT Study on the Tautomerization of β‐Alanine
Authors: Yamabe Shinichi , Tsuchida Noriko , Yamazaki Shoko 
Published: March 2024

AbstractTautomerization paths of β‐alanine with explicit inclusion of water molecules, (H2O)n, were investigated by DFT calculations, wB97X‐D/6‐311+G(d,p) SCRF=PCM. Structures of zwitterions of the alanine of trans (t−) and gauche (g−) conformations with seven water molecules (n=7) were examined. On the basis of those geometries, elementary processes of the tautomerization were investigated. For the t‐conformer of β‐alanine, reaction models of n=8, 10, 14, 18 and 24 were scrutinized. While reaction processes are slightly modified with different number of water molecules, n=18 and 24 models afforded three elementary reactions, t‐alanine with cis‐COOH→t‐ion pair→t‐alanine with trans‐COOH→t‐zwitterion. The (H2O)4 hydrogen‐bonded chain participates in the reactions. For the g‐conformer, models of n=7, 10, 14 and 18 were investigated, and the tautomerization was found to take place concertedly via (H2O)2.
Synthesis, Solvatochromic Studies, DFT Calculations, Characterization, and In Silico Molecular Docking Studies of Azo Dyes of 3‐Methyl‐1‐phenyl‐1H‐pyrazol‐5‐amine
Authors: Shakuntala R. B. , Keshavayya J. , Pampapathi S. 
Published: March 2024

AbstractIn this work, the four azo dyes (A1–A4) were synthesized using 5‐amino‐3‐methyl‐1‐phenyl pyrazole with four different coupling components by the conventional, simple diazo‐coupling method. These synthesized azo molecules were confirmed by various spectroscopic methods viz, FT‐IR spectra, HR‐MS spectra, 1H NMR spectra, and 13C NMR spectra. The electronic absorption and fluorescence spectra of synthesized azo compounds were recorded at room temperature, with different solvents. The DFT calculations were performed using 6‐311++G (d, p) basis set to evaluate the global reactive parameters of the synthesized azo dyes. The anti‐microbial activities were studied; the compound A1 exhibited a good antibacterial and anti‐fungal activities. The study of in silico molecular docking of the azo compounds revealed that all the compounds found to possess were extraordinary binding affinity as compared to the standards. The anti‐tuberculosis study was carried against mycobacterium tuberculosis and the results have shown that, the compound A2 showed good sensitivity to the studied azo compounds.
Erythrocyte Membrane Camouflaged Nanotheranostics for Optical Molecular Imaging‐Escorted Self‐Oxygenation Photodynamic Therapy
Authors: Wan Yilin , Li Chunying , Fu Lian‐Hua , Feng Ting , Zhang Yifan , Li Youyan , Lin Jing , Huang Peng , Cui Da‐Xiang 
Published: March 2024

AbstractHypoxic tumor microenvironment (TME) hampers the application of oxygen (O2)‐dependent photodynamic therapy (PDT) in solid tumors. To address this problem, a biomimetic nanotheranostics (named MMCC@EM) is developed for optical molecular imaging‐escorted self‐oxygenation PDT. MMCC@EM is synthesized by encapsulating chlorin e6 (Ce6) and catalase (CAT) in metal–organic framework (MOF) nanoparticles with erythrocyte membrane (EM) camouflage. Based on the biomimetic properties of EM, MMCC@EM efficiently accumulates in tumor tissues. The enriched MMCC@EM achieves TME‐activatable drug release, thereby releasing CAT and Ce6, and this process can be monitored through fluorescence (FL) imaging. In addition, endogenous hydrogen peroxide (H2O2) will be decomposed by CAT to produce O2, which can be reflected by the measurement of intratumoral oxygen concentration using photoacoustic (PA) imaging. Such self‐oxygenation nanotheranostics effectively mitigate tumor hypoxia and improve the generation of singlet oxygen (1O2). The 1O2 disrupts mitochondrial function and triggers caspase‐3‐mediated cellular apoptosis. Furthermore, MMCC@EM triggers immunogenic cell death (ICD) effect, leading to an increased infiltration of cytotoxic T lymphocytes (CTLs) into tumor tissues. As a result, MMCC@EM exhibits good therapeutic effects in 4T1‐tumor bearing mice under the navigation of FL/PA duplex imaging.
Multifunctional Liposomes Targeting Amyloid‐β Oligomers for Early Diagnosis and Therapy of Alzheimer's Disease
Authors: Senapati Sudipta , Tripathi Kuldeep , Awad Khadeja , Rahimipour Shai 
Published: March 2024

AbstractEarly detection and treatment are crucial for Alzheimer's disease (AD) management. Current diagnostic and therapeutic methods focus on late‐stage amyloid fibrils and plaques, overlooking toxic soluble amyloid β oligomers (AβOs) accumulating early in AD. A multifunctional liposome‐based platform is designed for early diagnosis and therapy of AD, leveraging a novel self‐assembled cyclic d,l‐α‐peptide (CP‐2) that selectively targets AβOs. Biocompatible CP‐2 conjugated liposomes (CP‐2‐LPs) effectively disrupt Aβ aggregation and mitigate Aβ‐mediated toxicity in human neuroblastoma cells. In transgenic Caenorhabditis elegans AD models, CP‐2‐LPs significantly outperformed free CP‐2 by improving cognitive and behavioral functions, extending lifespan, and reducing toxic AβO levels. Intravenous injection of fluorescently labeled CP‐2‐LPs reveals effective blood‐brain barrier penetration, with significantly higher brain fluorescence in transgenic mice than WT, enabling precise diagnosis. These findings underscore CP‐2‐LPs as a valuable tool for early detection and targeted therapy in AD.
Strain Engineering of Cd0.5Zn0.5S Nanocrystal for Efficient Photocatalytic Hydrogen Evolution from Wasted Plastic
Authors: Meng Ningjing , Li Mingjie , Yu Zebin , Sun Lei , Lian Cuifang , Mo Rongli , Jiang Ronghua , Huang Jun , Hou Yanping 
Published: March 2024

AbstractThe challenge of synthesizing nanocrystal photocatalysts with adjustable lattice strain for effective waste‐to‐energy conversion is addressed in this study. Cd0.5Zn0.5S (CZS) nanocrystals are synthesized by a simple solvothermal method, regulation of the ratio between N, N‐dimethylformamide, and water solvent are shown to provoke expansion and contraction, inducing an adjustable lattice strain ranging from −1.2% to 5.6%. With the hydrolyzed wasted plastic as a sacrificial agent, the 5.6% lattice‐strain CZS exhibited a robust hydrogen evolution activity of 1.09 mmol m−2 h−1 (13.83 mmol g−1 h−1), 4.5 times that of pristine CZS. Characterizations and density functional theory calculation demonstrated that lattice expansion increases the spatial distance between the valence band maximum and conduction band minimum, thus reducing carrier recombination and promoting charge transfer. Additionally, lattice expansion induces surface S vacancies and adsorbed OH groups, further enhancing redox reactions. This study focuses on the synchronous regulation of crystal structure, charge separation/transport, and surface reactions through lattice strain engineering, which providing a reference for the rational design of new photocatalysts for effective waste‐to‐energy conversion.
Constructing a Comprehensive Nanopattern Library through Morphological Transitions of Block Copolymer Surface Micelles via Direct Solvent Immersion
Authors: Bae Seokyoung , Kim Dong Hyup , Kim So Youn 
Published: March 2024

AbstractThis study establishes a comprehensive library of nanopatterns achievable by a single block copolymer (BCP), ranging from spheres to complex structures like split micelles, flower‐like clusters, toroids, disordered micelle arrays, and unspecified unique shapes. The ordinary nanostructures of polystyrene‐b‐poly(2‐vinylpyridine) (PS‐b‐P2VP) surface micelles deposited on a SiOx surface undergo a unique morphology transformation when immersed directly in solvents. Investigating parameters such as immersion solvents, BCP molecular weight, substrate interactions, and temperature, this work reveals the influence of these parameters on the thermodynamics and kinetics governing the morphology transformation. Additionally, the practical application of BCP nanopattern templates for fabricating metal nanostructures through direct solvent immersion of surface micelles is demonstrated. This approach offers an efficient and effective method for producing diverse nanostructures, with the potential to be employed in nanolithography, catalysts, electronics, membranes, plasmonics, and photonics.
Constructing Nano‐Heterostructure with Dual‐Site to Boost H2O2 Activation and Regulate the Transformation of Free Radicals
Authors: Shang Denghui , Wang Siyu , Li Jialu , Zhan Sihui , Hu Wenping , Li Yi 
Published: March 2024

AbstractA major issue with Fenton‐like reaction is the excessive consumption of H2O2 caused by the sluggish regeneration rate of low‐valent metal, and how to improve the activation efficiency of H2O2 has become a key in current research. Herein, a nano‐heterostructure catalyst (1.0‐MnCu/C) based on nano‐interface engineering is constructed by supporting Cu and MnO on carbon skeleton, and its kinetic rate for the degradation of tetracycline hydrochloride is 0.0436 min−1, which is 2.9 times higher than that of Cu/C system (0.0151 min−1). The enhancement of removal rate results from the introduced Mn species can aggregate and transfer electrons to Cu sites through the electron bridge Mn−N/O−Cu, thus preventing Cu2+ from oxidizing H2O2 to form O2•−, and facilitating the reduction of Cu2+ and generating more reactive oxygen species (1O2 and ·OH) with stronger oxidation ability, resulting in H2O2 utilization efficiency is 1.9 times as much as that of Cu/C. Additionally, the good and stable practical application capacity in different bodies demonstrates that it has great potential for practical environmental remediation.
Progress of Polymer Electrolytes Worked in Solid‐State Lithium Batteries for Wide‐Temperature Application
Authors: Hu Long , Gao Xue , Wang Hui , Song Yun , Zhu Yongli , Tao Zhijun , Yuan Bin , Hu Renzong 
Published: March 2024

AbstractSolid‐state Li‐ion batteries have emerged as the most promising next‐generation energy storage systems, offering theoretical advantages such as superior safety and higher energy density. However, polymer‐based solid‐state Li‐ion batteries face challenges across wide temperature ranges. The primary issue lies in the fact that most polymer electrolytes exhibit relatively low ionic conductivity at or below room temperature. This sensitivity to temperature variations poses challenges in operating solid‐state lithium batteries at sub‐zero temperatures. Moreover, elevated working temperatures lead to polymer shrinkage and deformation, ultimately resulting in battery failure. To address this challenge of polymer‐based solid‐state batteries, this review presents an overview of various promising polymer electrolyte systems. The review provides insights into the temperature‐dependent physical and electrochemical properties of polymers, aiming to expand the temperature range of operation. The review also further summarizes modification strategies for polymer electrolytes suited to diverse temperatures. The final section summarizes the performance of various polymer‐based solid‐state batteries at different temperatures. Valuable insights and potential future research directions for designing wide‐temperature polymer electrolytes are presented based on the differences in battery performance. This information is intended to inspire practical applications of wide‐temperature polymer‐based solid‐state batteries.
Power Scavenging Microsystem for Smart Contact Lenses
Authors: Pourshaban Erfan , Karkhanis Mohit U. , Deshpande Adwait , Banerjee Aishwaryadev , Hasan Md Rabiul , Nikeghbal Amirali , Ghosh Chayanjit , Kim Hanseup , Mastrangelo Carlos H. 
Published: March 2024

AbstractOn‐the‐eye microsystems such as smart contacts for vision correction, health monitoring, drug delivery, and displaying information represent a new emerging class of low‐profile (≤ 1 mm) wireless microsystems that conform to the curvature of the eyeball surface. The implementation of suitable low‐profile power sources for eye‐based microsystems on curved substrates is a major technical challenge addressed in this paper. The fabrication and characterization of a hybrid energy generation unit composed of a flexible silicon solar cell and eye‐blinking activated Mg–O2 metal–air harvester capable of sustainably supplying electrical power to smart ocular devices are reported. The encapsulated photovoltaic device provides a DC output with a power density of 42.4 µW cm−2 and 2.5 mW cm−2 under indoor and outdoor lighting conditions, respectively. The eye‐blinking activated Mg–air harvester delivers pulsed power output with a maximum power density of 1.3 mW cm−2. A power management circuit with an integrated 11 mF supercapacitor is used to convert the harvesters’ pulsed voltages to DC, boost up the voltages, and continuously deliver ≈150 µW at a stable 3.3 V DC output. Uniquely, in contrast to wireless power transfer, the power pack continuously generates electric power and does not require any type of external accessories for operation.
Hierarchical PtCuMnP Nanoalloy for Efficient Hydrogen Evolution and Methanol Oxidation
Authors: Basumatary Padmini , Choi Ji‐Hyeok , Konwar Dimpul , Ramchiary Anjalu , Han Byungchan , Yoon Young Soo 
Published: March 2024

AbstractThe higher amount of Pt usage and its poisoning in methanol oxidation reaction in acidic media is a major setback for methanol fuel cells. Herein, a promising dual application high‐performance electrocatalyst has been developed for hydrogen evolution and methanol oxidation. A low Pt‐content nanoalloy co‐doped with Cu, Mn, and P is synthesized using a modified solvothermal process. Initially, ultrasmall ≈2.9 nm PtCuMnP nanoalloy is prepared on N‐doped graphene‐oxide support and subsequently, it is characterized using several analytical techniques and examined through electrochemical tests. Electrochemical results show that PtCuMnP/N‐rGO has a low overpotential of 6.5 mV at 10 mA cm−2 in 0.3 m H2SO4 and high mass activity for the hydrogen evolution reaction. For the methanol oxidation reaction, the PtCuMnP/N‐rGO electrocatalyst exhibits robust performance. The mass activity of PtCuMnP/N‐rGO is 6.790 mA mg−1Pt, which is 7.43 times higher than that of commercial Pt/C (20% Pt). Moreover, in the chronoamperometry test, PtCuMnP/N‐rGO shows exceptionally good stability and retains 72% of the initial current density even after 20,000 cycles. Furthermore, the PtCuMnP/N‐rGO electrocatalyst exhibits outstanding performance for hydrogen evolution and methanol oxidation along with excellent anti‐poisoning ability. Hence, the developed bifunctional electrocatalyst can be used efficiently for hydrogen evolution and methanol oxidation.
Polymorphism and Structural Variety in Sn(II) Carboxylate Coordination Polymers Revealed from Structure Solution of Microcrystals
Authors: Ramana Avneet K. , Tidey Jeremiah P. , de Lima Geraldo M. , Walton Richard I. 
Published: March 2024

AbstractThe crystal structures of four coordination polymers constructed from Sn(II) and polydentate carboxylate ligands are reported. All are prepared under hydrothermal conditions in KOH or LiOH solutions (either water or methanol–water) at 130−180 °C and crystallize as small crystals, microns or less in size. Single‐crystal structure solution and refinement are performed using synchrotron X‐ray diffraction for two materials and using 3D electron diffraction (3DED) for the others. Sn2(1,3,5‐BTC)(OH), where 1,3,5‐BTC is benzene‐1,3,5‐tricarboxylate, is a new polymorph of this composition and has a three‐dimensionally connected structure with potential for porosity. Sn(H‐1,3,5‐BTC) retains a partially protonated ligand and has a 1D chain structure bound by hydrogen bonding via ─COOH groups. Sn(H‐1,2,4‐BTC) contains an isomeric ligand, benzene‐1,2,4‐tricarboxylate, and contains inorganic chains in a layered structure held by hydrogen bonding. Sn2(DOBDC), where DOBDC is 2,5‐dioxido‐benzene‐1,4‐dicarboxylate, is a new polymorph for this composition and has a three‐dimensionally connected structure where both carboxylate and oxido groups bind to the tin centers to create a dense network with dimers of tin. In all materials, the Sn centers are found in highly asymmetric coordination, as expected for Sn(II). For all materials phase purity of the bulk is confirmed using powder X‐ray diffraction, thermogravimetric analysis, and infrared spectroscopy.
Regulating The Electronic Configuration of Low‐Dimensional Hybrid Perovskites via Organic Cations for Self‐Powered Ultraviolet Photodetectors
Authors: Liu Zhirong , Zhang Zhiguo , Yu Haixuan , Zhang Zheng , Li Xiongjie , Sun Qiang , Dong Hongliang , Liang Wenxi , Shen Yan , Ahmad Shahzada , Wang Mingkui 
Published: March 2024

AbstractUltraviolet photodetectors (UPDs) based on low‐dimensional halide perovskites have undergone rapid development. Here, regulation of the electronic configuration of low‐dimensional hybrid perovskites are reported via organic cations for self‐powered UPDs. For the first time, it is determine that the rational design of organic cation phenyl alkylammonium can effectively prevent phonon scattering thus increasing charge carrier extraction in low dimensional lead chlorine perovskite thin‐films. As a result, the exciton‐binding energy can be reduced to 62.91 meV in (PMA)2PbCl4 perovskite films with a charge‐carrier mobility of 0.335 cm2 V−1 s−1. The fabricated (PMA)2PbCl4‐based self‐powered UPDs has achieved a high detectivity of 6.32 × 1013 jones with a low noise current of 0.35 pA Hz−1/2 under zero bias. A further demonstration of images with high UV to visible light rejection ratio under weak‐light illumination of 70 nW cm−2 highlights the feasible potential application of low‐dimensional perovskite.
A new validated high‐performance liquid chromatography method for the determination of regorafenib in rat plasma: Application for pharmacokinetic study
Authors: Aydoğmuş Zeynep , Yılmaz Ece Merve , Öztürk Seyhan Narin , Okyar Alper 
Published: March 2024

AbstractThis study reports a rapid and sensitive reversed‐phase high‐performance liquid chromatography method with ultraviolet detection for the determination of regorafenib (REG) in rat plasma. For the extraction of REG from plasma and the precipitation of plasma proteins, a rapid one‐step precipitation method was performed with methanol. The separation was performed in a methanol‐water mixture (80:20, v:v) mobile phase system with a C18 column and monitored at a wavelength of 258 nm. Nilotinib was used as an internal standard. The linear dynamic range of REG was determined between 5 and 500 ng/mL in standard solution and plasma. The limit of detection of REG from the standard solution was found to be 1.23 ng/mL and the limit of quantitation was 3.73 ng/mL. The limit of detection of REG from plasma was found to be 1.55 ng/mL and the limit of quantitation was 4.70 ng/mL. Regorafenib was administered at 5 mg/kg to 10 healthy male Sprague Dawley rats, and pharmacokinetic results were evaluated. It exhibited a high recovery of 93.82% in plasma. Due to ease of sample preparation, high susceptibility, specificity, and certainty, the described method can be used successfully in the quantification of REG in in‐vivo plasma and in routine analyses in clinical laboratories.
Experiments on shear behavior of reinforced concrete continuous beams strengthened by C‐FRCM
Authors: Feng Ran , Tang Jing‐Pu , Wang Fangying , Wang Sen , Zeng Jun‐Jie , Zhu Ji‐Hua 
Published: March 2024

AbstractThe dual‐function retrofitting system that uses the carbon‐fabric reinforced cementitious matrix (C‐FRCM) as both the anode of impressed current cathodic protection (ICCP) system and the structural strengthening (SS) material, that is, an ICCP‐SS system, is investigated. The experimental program mainly focused on the shear behavior of C‐FRCM strengthened reinforced concrete (RC) continuous beam under the dual‐function retrofitting system. The influence of anode polarization on the shear strengthening of RC continuous beams is analyzed. Shear tests were conducted on a total of 14 corroded RC continuous beams to investigate the influence of key parameters, including anode polarization degree of prefabricated C‐FRCM plate, layer of carbon fiber mesh and side‐wrapping. The failure modes, shear capacities, and load‐deflection curves of the shear‐strengthened RC continuous beams are reported. Based on the test results, the applicability of relevant design codes was evaluated and found to provide rather conservative predictions for the shear capacity of the examined C‐FRCM strengthened RC continuous beams.