bluuebunny/crossref_metadata_2025_split huggingface dataset:
NCAPH serves as a prognostic factor and promotes the tumor progression in glioma through PI3K/AKT signaling pathway
Authors: Liang Jianshen , Yun Debo , Jin Wenzhe , Fan Jikang , Wang Xuya , Wang Xisen , Li Yiming , Yu Shengping , Zhang Chen , Li Tao , Yang Xuejun 
Published: April 2024

AbstractNon-SMC (Structural Maintenance of Chromosomes) condensin I complex subunit H (NCAPH) has been shown to facilitate progression and predict adverse prognostic outcome in many cancer types. However, the function of NCAPH in gliomas is still unclear. Series of experiments were taken to uncover the function of NCAPH in glioma. The expression of NCAPH and potential mechanism regulating progression of glioma was verified by bioinformatics analysis. Lentiviral transfection was used for establishment of loss-of-function and gain-of-function cell lines. CCK-8 assay and Colony-formation assay were used to evaluate proliferation. Transwell assay and Cell wound healing assay were used to assess migration and invasion. Cell cycle and apoptosis were measured by flow cytometry. Protein and RNA were quantified by WB and RT-PCR, respectively. The nude mice model of glioma was used to evaluate the effect of NCAPH in vivo. The expression of NCAPH increased significantly in glioma tissues and correlated with WHO grade, IDH wild-type and non-1p/19q codeletion. Glioma patients with high expression of NCAPH had an undesirable prognosis. Functionally, upregulated NCAPH promotes the malignant hallmarks of glioma cells in vivo and in vitro. NCAPH correlated with DNA damage repair ability of glioma cells and facilitated the proliferation, invasion, and migration of glioma cells by promoting the PI3K/AKT signaling pathway. This study identifies the important pro-tumor role of NCAPH in glioma and suggests that NCAPH is a potential therapeutic target.
A critical review on Pulicaria species occurring in Qatar: traditional uses, phytochemistry and biological activities
Authors: Kasote Deepak M. , Nawaz Malik Adil , Usman Kamal , Ullah Najeeb , Alsafran Mohammed 
Published: April 2024

AbstractIn Qatar, three main species of Pulicaria (from Asteraceae) such as Pulicaria undulata (L.) C.A.Mey, Pulicaria gnaphalodes (Vent.) Boiss. and Pulicaria sicula (L.) Moris are reported. Traditionally, these species have almost the same ethnomedical uses, including their use as herbal tea. This could be because of morphological similarities among some of these species, which also results in taxonomic ambiguity. Altogether, this indicates that these species need to be reviewed comparatively, to understand the phytochemical uniqueness and therapeutic significance of each species individually, including species differentiation at the subspecies level. Hence, this review aims to comparatively review the available literature about traditional uses, phytochemistry, and bio-activities of these species. Being aromatic plants, the chemical composition of essential oils of these species has been extensively studied and reported over 300 volatile organic compounds. Among these, oxygenated monoterpenes and sesquiterpenes are dominant. The diverse and distinguishable composition of essential oils can differentiate P. undulata and Pulicaria crispa (Forssk.) Oliv. (Synonyme: Pulicaria undulata subsp. undulata). Likewise, flavonoids and sesquiterpenes are the most reported classes of compounds in non-essential oil fractions. Various biological and pharmacological activities are reported to the essential oils, crude extracts, and their fractions, or isolated compounds of these species. Among these, antimicrobial, anticancer, and anti-oxidant activities were mostly investigated, mainly under in vitro conditions. Several distinguishable compounds are listed for each species that can potentially be used as chemical markers while characterizing these species. Most of the traditional claims of these species are validated in recent scientific studies. However, further detailed in vivo clinical interventions are needed for their potential use as therapeutic agents.
Comparison of Metabolic Profiles of Fruits of Arctium lappa, Arctium minus, and Arctium tomentosum
Authors: Malaník Milan , Farková Veronika , Křížová Jitka , Kresová Alice , Šmejkal Karel , Kašparovský Tomáš , Dadáková Kateřina 
Published: April 2024

AbstractMetabolites of the edible and medicinal plant Arctium have been shown to possess beneficial activities. The phytochemical profile of Arctium lappa is well-explored and its fruits are known to contain mainly lignans, fatty acids, and sterols. But the fruits of other Arctium species have not been thoroughly investigated. Therefore, this study compares the metabolic profiles of the fruits of A. lappa, Arctium tomentosum, and Arctium minus. Targeted metabolomics led to the putative identification of 53 metabolites in the fruit extracts, the majority of these being lignans and fatty acids. Quantification of the major lignans showed that the year of collection had a significant effect on the lignan content. Furthermore, A. lappa fruits contained lesser amounts of arctigenin but greater amounts of arctigenin glycoside than A. minus fruits. Regarding the profile of fatty acids, A. minus fruits differed from the others in the presence of linolelaidic acid.
Graphical Abstract
Memory-based modes of presentation
Authors: Recanati François 
Published: April 2024

AbstractTo deal with memory-based modes of presentation I propose a couple of revisions to the standard criterion of difference for modes of presentation attributed to Frege. First, we need to broaden the scope of the criterion so that not merely the thoughts of a given subject at a given time may or may not involve the same way of thinking of some object, but also the thoughts of a subject at different times. Second, we need to ‘relativize’ the criterion of difference to particular subjects in particular situations. Thanks to these revisions, we can make sense of Evans’ notion of a dynamic mode of presentation that persists through time despite lower-level changes. A dynamic mode of presentation is a complex mode of presentation involving several epistemically rewarding relations to the reference successively (in contrast to composite modes of presentation, which involve several epistemically rewarding relations simultaneously). I show how this idea can be cashed out in the mental file framework, and how, in that framework, we can provide a straightforward answer to the question: when is a mode of presentation based on a memory M the same as the mode of presentation based on the perception P from which the memory derives? The answer appeals to the distinction between anchored and unanchored memories.
Hyperintensionality and overfitting
Authors: Berto Francesco 
Published: April 2024

AbstractA hyperintensional epistemic logic would take the contents which can be known or believed as more fine-grained than sets of possible worlds. I consider one objection to the idea: Williamson’s Objection from Overfitting. I propose a hyperintensional account of propositions as sets of worlds enriched with topics: what those propositions, and so the attitudes having them as contents, are about. I show that the account captures the conditions under which sentences express the same content; that it can be pervasively applied in formal and mainstream epistemology; and that it is left unscathed by the objection.
Removal of neonicotinoids present in secondary effluents by ferrate(VI)-based oxidation processes
Authors: Real Francisco J. , Acero Juan L. , Matamoros Esther 
Published: April 2024

AbstractThe persistence in the environment and possible harmful effects of neonicotinoid insecticides have raised some concerns, which have led to the proposal of various measures for their remediation. The aim of this work was to study the elimination of five neonicotinoids (thiamethoxam (THM), imidacloprid (IMI), clothianidin (CLO), thiacloprid (THC), and acetamiprid (ACE)) using ferrate (Fe(VI)) as the oxidizing agent. Firstly, second-order rate constants for the reactions of neonicotinoids with Fe(VI) were determined at different pHs. The most reactive compound was THC, with a rate constant of 400 ± 43 M−1 s−1 at pH 8 (the optimum pH considering the predominance of the most reactive species (HFeO4−) and the decreasing self-decomposition of Fe(VI) with pH), followed by CLO (10.7 ± 1.7 M−1 s−1), THM (9.7 ± 0.7 M−1 s−1), and IMI (2.5 ± 0.6 M−1 s−1). ACE did not significantly react with Fe(VI). The oxidation of the selected pollutants in secondary effluents by Fe(VI) was rather slow, and only THC could be efficiently removed. The presence of natural organic matter (NOM) exerted a negative influence on the removal of the neonicotinoids of moderate reactivity with Fe(VI) (CLO, THM, and IMI). The additional presence of peroxymonosulfate (Fe(VI)/PMS system) slightly increased the removal of neonicotinoids due to the formation of hydroxyl and sulfate radicals. Finally, the application of the Fe(VI)/sulfite system considerably increased the oxidation rate of the selected pollutants, with enhanced formation of hydroxyl and, especially, sulfate radicals. Overall, these results suggest that the Fe(VI)/sulfite system has significant potential to address environmental and health concerns associated with neonicotinoids in water sources with low NOM content.
Graphical abstract
Serious games in high-stakes assessment contexts: a systematic literature review into the game design principles for valid game-based performance assessment
Authors: Bijl Aranka , Veldkamp Bernard P. , Wools Saskia , de Klerk Sebastiaan 
Published: April 2024

AbstractThe systematic literature review (1) investigates whether ‘serious games’ provide a viable solution to the limitations posed by traditional high-stakes performance assessments and (2) aims to synthesize game design principles for the game-based performance assessment of professional competencies. In total, 56 publications were included in the final review, targeting knowledge, motor skills and cognitive skills and further narrowed down to teaching, training or assessing professional competencies. Our review demonstrates that serious games are able to provide an environment and task authentic to the target competency. Collected in-game behaviors indicate that serious games are able to elicit behavior that is related to a candidates’ ability level. Progress feedback and freedom of gameplay in serious games can be implemented to provide an engaging and enjoyable environment for candidates. Few studies examined adaptivity and some examined serious games without an authentic environment or task. Overall, the review gives an overview of game design principles for game-based performance assessment. It highlights two research gaps regarding authenticity and adaptivity and concludes with three implications for practice.
Ethnic–Racial Discrimination Exposure and Anxiety in Latina Girls: Amygdala Volume as an Indirect Neurobiological Pathway
Authors: Mullins Jordan L. , Díaz Dana E. , Firat Rengin B. , Michalska Kalina J. 
Published: April 2024

AbstractEthnic–racial discrimination, the differential treatment of individuals based on ethnic or racial group membership, predicts poor mental health outcomes such as anxiety. This is supported by long-standing theories on the social determinants of health and minority stress. However, these theories are rarely expanded to neurobiological sciences, limiting our understanding of mechanisms underlying observed associations. One potential neurobiological pathway between ethnic–racial discrimination exposure and anxiety is that ongoing exposure to racially charged encounters presents imminent threats that may modify stress-sensitive neurocircuitry, like the amygdala.The current study evaluated whether amygdala volume mediated associations between ethnic–racial discrimination exposure and anxiety symptoms in Latina girls, a group exhibiting heightened levels of untreated anxiety and disproportionately subjected to ethnic–racial discrimination.Thirty predominantly Mexican-identifying Latina girls residing in Southern California (MAge = 9.76, SD = 1.11 years) completed a T1-weighted structural MRI scan. Using the Perceptions of Racism in Children and Youth, participants self-reported the prevalence and severity of various discriminatory experiences. Participants also self-reported their anxiety symptoms via the Screen for Child Anxiety and Related Emotional Disorders. Controlling for total intracranial volume and annual household income, an indirect effect of ethnic–racial discrimination on anxiety symptoms via left amygdala volume was observed, β = −0.28, SE = 0.17, BC 95% CI [−0.690, −0.017]. The current findings suggest that the left amygdala is sensitive to racialized threats in childhood and that stress-related alterations may, in part, contribute to elevated anxiety in Latina girls. Our data elucidate a potential mechanism by which this form of sociocultural stress can adversely impact mental health, particularly in the transition from middle childhood to early adolescence, a period marked by a host of interlinked neurophysiological and social changes.
Mapping lock-ins and enabling environments for agri-food sustainability transitions in Europe
Authors: Williams Tim G. , Bürgi Matthias , Debonne Niels , Diogo Vasco , Helfenstein Julian , Levers Christian , Mohr Franziska , Stratton Anne Elise , Verburg Peter H. 
Published: April 2024

AbstractEuropean agri-food systems must overcome structural lock-ins to achieve more sustainable modes of production and consumption. Yet European regions are highly diverse, and we lack understanding of how different regional characteristics may enable or inhibit sustainability transitions. This hinders the development of context-tailored governance strategies. In this paper, we identify and apply sets of spatial indicators to map the regional potentials for agri-food transitions. We first analyse the strength of lock-in to the incumbent agro-industrial paradigm. We then map the enabling environments for two alternative agri-food networks—multifunctional value chains and civic food networks—that each embed distinct social–ecological qualities of agriculture and food. Results demonstrate a large spatial diversity in transition potential, with stronger lock-ins throughout North and Western Europe and stronger enabling environments for agri-food transitions in Italy, France, Switzerland, and Southwest Germany. We find that lock-ins are strongest in livestock-dominated regions and are associated with higher GHG emissions and excess nitrogen levels. Our study demonstrates the need for coordinated public policies that (1) leverage region-specific transition potentials and (2) enable complementary innovations in market-based and community-led networks.
Hydrothermal alteration of the surface volcanic rocks at the Acoculco geothermal field, Mexico: a multi-parametric approach
Authors: García-Soto America Yosiris , Pandarinath Kailasa , Santoyo E. , Gonzalez-Partida Eduardo 
Published: April 2024

AbstractThe studies on hydrothermal alteration-induced effects in surface and subsurface rocks provide useful information in the characterization and exploitation of a geothermal reservoir. Generally, these studies are based on traditional, and reliable methods like petrography (primary and secondary minerals, and grade of alteration), and geochemistry (mobility of elements, changes in mass and concentration of elements, and fluid inclusions). Recently, apart from these established methods, some methods based on the geochemical (Chemical Index of Alteration, CIA; Weathering Index of Parkar, WIP; Loss on Ignition, LOI; and Sulfur, S) and rock magnetic properties (magnetic susceptibility, χlf; and percentage frequency-dependent susceptibility, χfd%) are also being applied in the identification of whether a rock is an altered or a fresh one. The Acoculco Geothermal Field (AGF), Mexico, is characterized by high temperature and very low permeability, and it is considered a promissory Enhanced Geothermal System. The following changes are observed in the rocks as a result of an increase in hydrothermal alteration: (1) an increase in CIA, LOI, and S values, and a decrease in WIP; (2) an increase in quartz and quartz polymorph minerals (silicification), and clay minerals (argillization); and (3) decrease in χlf values. At AGF, the most altered surface acid rocks are characterized by entirely quartz and its polymorphs, and clay minerals. The present study also indicates the applicability of the binary plots of major elements (felsic vs mafic component) and rock magnetic parameters (χlf vs. χfd%). The rock with χfd% value of 2–10 and χlf value < 0.5 × 10–6 m3 kg−1 indicate the presence of single domain and stable single domain grains, which in turn suggests that it is an altered rock. These methods are simple to apply, rapid, reliable, and have the potential to become effective tools for the identification of hydrothermally altered rocks during the initial stage of geothermal exploration.
The Effect of Depth of Anesthesia on Postoperative Pain in Laparoscopic Sleeve Gastrectomy: A Randomized Controlled Trial
Authors: Zhang Xue , Chen Xin-Yue , Gao Rui-Jia , Huang Yu , Mao Shi-Meng , Feng Ji-Ying 
Published: April 2024

Abstract
Background
Patients with obesity are more sensitive to pain and more likely to have acute postoperative pain (APP). Studies have shown that the depth of anesthesia may affect the incidence of APP. The purpose of the study was to look into the connection between APP and depth of anesthesia in patients with obesity undergoing laparoscopic sleeve gastrectomy.

Methods
This is a prospective, double-blinded randomized clinical trial, 90 patients undergoing laparoscopic sleeve gastrectomy were randomly divided into two groups: the light anesthesia group (Bispectral Index of 50, BIS 50) and the deep anesthesia group (BIS 35). The degree of pain was evaluated by the visual analogue scale (VAS) at 0, 12, 24, 48, and 72 h after surgery. The use of analgesics, grade of postoperative nausea and vomiting (PONV), and the Quality of Recovery-15 (QoR-15) score were recorded.

Results
The VAS scores at rest or coughing at 0, 12, and 24 h after surgery in the BIS 35 group were lower than those in the BIS 50 group (P < 0.05). Fewer patients in the deep anesthesia group needed analgesia during the recovery period, and patient satisfaction was higher on the 3rd day after surgery (P < 0.015, P < 0.032, respectively).

Conclusions
For patients with obesity, maintaining a deeper depth of anesthesia during surgery is beneficial to reduce APP causes less need for additional analgesic drugs, and improves patient satisfaction.

Graphical Abstract
Employment status in cancer patients the first five years after diagnosis—a register-based study
Authors: Brink E. , Pilegaard M. S. , Bonnesen T. G. , Nielsen C. V. , Pedersen P. 
Published: April 2024

Abstract
Purpose
Work is important for identity formation, social status, and economic independency. Although some evidence within the field of work and cancer survivorship exists, no study has so far investigated employment status across all cancer diagnoses. Thus, the aim of the present study was to investigate the impact of all cancer diagnoses on employment status.

Methods
Danish cancer patients aged 20–60 years, diagnosed between 2000 and 2015, were identified through Danish registers and matched 1:5 with cancer-free controls. Logistic and linear regression was performed separately in 11 cancer types to assess and compare work status and work participation between cancer patients and cancer-free controls one, three, and five years after diagnosis.

Results
A total of 111,770 cancer patients and 507,003 cancer-free controls were included. All cancer types had lower chances of working one year after diagnosis (ORs between 0.05 and 0.76), with lung, colorectal, upper gastrointestinal, and blood cancer patients having the lowest chances. After three years, 10 of 11 cancer types had lower chances (ORs between 0.39 and 0.84). After five years, there were minimal differences between cancer patients and controls among most cancer types (ORs between 0.75 and 1.36).

Conclusion
Most cancer patients had lower chances of working compared with the general population until five years after diagnosis. However, patients with certain cancer types experienced lower chances of working all years, despite improvement over time.

Implications for Cancer Survivors
The knowledge will help increase awareness on challenges regarding work-life after cancer. Furthermore, the distinguishing between diagnoses can inform to more targeted vocational rehabilitation.
Vilazodone Alleviates Neurogenesis-Induced Anxiety in the Chronic Unpredictable Mild Stress Female Rat Model: Role of Wnt/β-Catenin Signaling
Authors: El-Kadi Rana A. , AbdelKader Noha F. , Zaki Hala F. , Kamel Ahmed S. 
Published: April 2024

AbstractDefective β-catenin signaling is accompanied with compensatory neurogenesis process that may pave to anxiety. β-Catenin has a distinct role in alleviating anxiety in adolescence; however, it undergoes degradation by the degradation complex Axin and APC. Vilazodone (VZ) is a fast, effective antidepressant with SSRI activity and 5-HT1A partial agonism that amends somatic and/or psychic symptoms of anxiety. Yet, there is no data about anxiolytic effect of VZ on anxiety-related neurogenesis provoked by stress-reduced β-catenin signaling. Furthermore, females have specific susceptibility toward psychopathology. The aim of the present study is to uncover the molecular mechanism of VZ relative to Wnt/β-catenin signaling in female rats. Stress-induced anxiety was conducted by subjecting the rats to different stressful stimuli for 21 days. On the 15th day, stressed rats were treated with VZ(10 mg/kg, p.o.) alone or concomitant with the Wnt inhibitor: XAV939 (0.1 mg/kg, i.p.). Anxious rats showed low β-catenin level turned over by Axin-1 with unanticipated reduction of APC pursued with elevated protein levels of neurogenesis-stimulating proteins: c-Myc and pThr183-Erk likewise gene expressions of miR-17-5p and miR-18. Two weeks of VZ treatment showed anxiolytic effect figured by alleviation of hippocampal histological examination. VZ protected β-catenin signal via reduction in Axin-1 and elevation of APC conjugated with modulation of β-catenin downstream targets. The cytoplasmic β-catenin turnover by Axin-1 was restored by XAV939. Herein, VZ showed anti-anxiety effect, which may be in part through regaining the balance of the reduced β-catenin and its subsequent exaggerated response of p-Erk, c-Myc, Dicer-1, miR-17-5p, and miR-18.
Graphical Abstract
Optimized BEAC conditioning regimen improves clinical outcomes of autologous hematopoietic stem cell transplantation in non-Hodgkin lymphomas
Authors: Zhou Sha , Rao Jun , Ma Xiangyu , Zeng Yunjing , Xiang Xixi , Li Jiali , Liu Hongyun , Lin Shijia , Dong Song , Li Fu , Zhang Xi , Gao Li 
Published: April 2024

AbstractThe conditioning regimen is an important part of autologous hematopoietic stem cell transplantation (ASCT). We explored the efficacy and safety of an optimized BEAC (adjusted-dose, intermediate-dose cytarabine and reduced-dose cyclophosphamide, AD-BEAC) conditioning regimen for non-Hodgkin lymphoma (NHL). A total of 141 NHL patients received AD-BEAC or a standard-dose BEAC (SD-BEAC) conditioning regimen from January 2007 to December 2017, and 104 patients were included in the study after 1:1 propensity matching. The 5-year overall survival (OS) and progression free survival (PFS) rates were significantly higher with AD-BEAC than with SD-BEAC (82.7% vs. 67.3%, P = 0.039; 76.9% vs. 57.7%, P = 0.039). Transplant-related mortality (TRM) was 3.8% in both the AD-BEAC and SD-BEAC groups. The AD-BEAC group had lower incidence of oral ulcers and cardiotoxicity than the SD-BEAC group. An optimized BEAC conditioning regimen is an effective conditioning regimen for ASCT in NHL with acceptable toxicity, that is more effective and safer than a standard BEAC conditioning regimen.