bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-analysis on safety of standard vs prolonged infusion of beta-lactams
Authors: Rolain Hunter , Schwartz Zachary , Jubriail Raymond , Downes Kevin , Hong Lisa , Ravari Alireza Fakhri , Rhodes Nathaniel J. , Scheetz Marc H. 
Published: April 2024

AbstractBackgroundEfficacy for prolonged infusion beta-lactam dosing schemes has been previously described, but there has been less focus on the safety of standard vs prolonged infusion protocols of beta-lactams. This study explored differences in adverse drug reactions (ADRs) reported for beta-lactams between each of these infusion protocols.MethodsA systematic review of MEDLINE literature databases via PubMed was conducted and references were compiled. Articles were compiled and assessed with specific inclusion/exclusion criteria. We included randomized and nonrandomized, prospective, and retrospective cohort studies that reported adverse effects due to either standard (30-60 mins) or prolonged (≥3 hours) infusions of beta-lactam infusions. Total ADRs between strategies were analyzed by infusion methodology. The most consistently reported ADRs were subject to meta-analysis across studies.Results13 studies met inclusion/exclusion criteria with data for 4184 patients. There was insufficient data to systematically analyze neurotoxicity or cytopenias. Eight studies reported on nephrotoxicity outcomes with no significant difference in event rates between standard (n=440/2117, 20.8%) vs prolonged infusion (n=264/1284, 20.6%) of beta-lactams (OR=1.09, 95% CI [0.91, 1.30]). Six studies reported on rates of diarrhea with no significant difference in event rates between standard (n=21/359, 5.8%) vs prolonged infusion (n=25/330, 7.6%) of beta-lactams (OR=1.33, 95% CI [0.71,2.47).ConclusionProlonged and standard infusion schemes for beta-lactams demonstrated adverse effects at similar rates for both infusion schemes. Future research should focus on improved standardization of adverse effect definitions and a priori aim to study neurotoxicity and cytopenias. Consistent recording of ADRs and standardized definitions of these reactions will be paramount to further study of this subject.
Microstructural asymmetry in the human cortex
Authors: Wan Bin , Saberi Amin , Paquola Casey , Schaare H. Lina , Hettwer Meike D. , Royer Jessica , John Alexandra , Dorfschmidt Lena , Bayrak Şeyma , Bethlehem Richard A.I. , Eickhoff Simon B. , Bernhardt Boris C. , Valk Sofie L. 
Published: April 2024

AbstractWhile macroscale brain asymmetry and its relevance for human cognitive function have been consistently shown, the underlying neurobiological signatures remain an open question. Here, we probe layer-specific microstructural asymmetry of the human cortex using intensity profiles frompost-mortemcytoarchitecture. An anterior-posterior cortical pattern of left-right asymmetry was found, varying across cortical layers. A similar anterior-posterior pattern was observed usingin vivomicrostructural imaging, within vivoasymmetry showing the strongest similarity with layer III. Microstructural asymmetry varied as a function of age and sex and was found to be heritable. Moreover, asymmetry in microstructure corresponded to asymmetry of intrinsic function, in particular in sensory areas. Last, probing the behavioral relevance, we found differential association of language and markers of mental health with asymmetry, illustrating a functional divergence between inferior-superior and anterior-posterior microstructural axes anchored in microstructural development. Our study highlights the layer-based patterning of microstructural asymmetry of the human cortex and its functional relevance.
Measuring the burden of hundreds of BioBricks defines an evolutionary limit on constructability in synthetic biology
Authors: Radde Noor , Mortensen Genevieve A. , Bhat Diya , Shah Shireen , Clements Joseph J. , Leonard Sean P. , McGuffie Matthew J. , Mishler Dennis M. , Barrick Jeffrey E. 
Published: April 2024

ABSTRACTEngineered DNA will slow the growth of a host cell if it redirects limiting resources or otherwise interferes with homeostasis. Populations of engineered cells can rapidly become dominated by “escape mutants” that evolve to alleviate this burden by inactivating the intended function. Synthetic biologists working with bacteria rely on genetic parts and devices encoded on plasmids, but the burden of different engineered DNA sequences is rarely characterized. We measured how 301 BioBricks on high-copy plasmids affected the growth rate ofEscherichia coli. Of these, 59 (19.6%) negatively impacted growth. The burden imposed by engineered DNA is commonly associated with diverting ribosomes or other gene expression factors away from producing endogenous genes that are essential for cellular replication. In line with this expectation, BioBricks exhibiting burden were more likely to contain highly active constitutive promoters and strong ribosome binding sites. By monitoring how much each BioBrick reduced expression of a chromosomal GFP reporter, we found that the burden of most, but not all, BioBricks could be wholly explained by diversion of gene expression resources. Overall, no BioBricks reduced the growth rate ofE. coliby >45%, which agreed with a population genetic model that predicts such plasmids should be “unclonable” because escape mutants will take over during growth of a bacterial colony or small laboratory culture from a transformed cell. We made this model available as an interactive web tool for synthetic biology education and added our burden measurements to the iGEM Registry descriptions of each BioBrick.
Ribosome cooperativity promotes fast and efficient translation
Authors: Madern Maximilian F. , Yang Sora , Tanenbaum Marvin E. 
Published: April 2024

AbstractThe genetic information stored in mRNA is decoded by ribosomes during mRNA translation. mRNAs are typically translated by multiple ribosomes simultaneously, but it is unclear if different ribosomes translating the same mRNA functionally interact with each other. Here, we combine single-ribosome imaging and simulations to compare translation dynamics of individual ribosomes in either monosomes or polysomes to determine how ribosomes interact during translation. We find that ribosomes frequently undergo transient collisions, but that transient collisions, unlike persistent collisions, escape detection by cellular quality control pathways. Instead, our results indicate that transient ribosome collisions promote productive translation by suppressing ribosome pausing when ribosomes encounter problems, a process we term ribosome cooperativity. Ribosome cooperativity also suppresses ribosome recycling on problematic sequences, likely by reducing pause duration, thus stimulating processive translation. Together, our results show that ribosomes cooperate during translation to ensure fast and efficient translation.
An empirical evaluation of the performance of Nigerian pension fund managers
Authors: Ajadi Adedeji David 
Published: April 2024

PurposeThis paper evaluates the risk-adjusted returns, selectivity, market timing skills and persistence of the performance of Nigerian pension funds.Design/methodology/approachAnnual return data of 23 pension funds that operated in Nigeria between 2018 and 2022 were obtained from the National Pension Commission (PenCom). Risk-adjusted return was appraised using the Treynor ratio, Sharpe ratio and Jensen alpha, while the Treynor–Mazuy and Henriksson–Merton multiple regression models were applied to decompose selective and timing skills. Performance persistence was assessed using the contingency table and rank correlation models.FindingsEvidence shows that pension funds deliver excess risk-adjusted returns and exhibit selective skills. However, the evidence does not support the presence of timing skills, and there is overwhelming evidence that good (bad) performance does not repeat.Practical implicationsAn evaluation of the investment performance of pension funds is crucial for ensuring the financial stability of retirees, maintaining economic stability and making informed investment decisions. It serves the interests of pensioners, pension fund managers, regulators and the broader economy. Our evidence that pension funds generate positive excess returns is a departure from most of the literature on managed funds. We recommend that more Nigerians should leverage the pension fund industry to grow their wealth and prepare for retirement.Originality/valueThis study, to our knowledge, is the first to appraise all the key facets of the investment performance of pension funds in the Nigerian context.
Cultural variation in hiring people with disabilities: a theory and preliminary test
Authors: Thomas David , Muibi Aminat , Hsu Anna , Ekelund Bjørn , Wasvik Mathea , Barzantny Cordula 
Published: April 2024

PurposeThe goal of this study is to propose and test a model of the effect of the socio-cultural context on the disability inclusion climate of organizations. The model has implications of hiring people with disabilities.Design/methodology/approachTo test the model, we conducted a cross-sectional study across four countries with very different socio-cultural contexts. Data were gathered from 266 managers with hiring responsibilities in Canada, China, Norway and France. Participants responded to an online survey that measured the effect of societal based variables on the disability inclusion climate of organizations.FindingsResults indicated support for the theoretical model, which proposed that the socio-cultural context influenced the disability inclusion climate of organizations through two distinct but related paths; manager’s value orientations and their perception of the legitimacy of legislation regarding people with disabilities.Originality/valueThe vast majority of research regarding employment of people with disabilities has focused on supply side factors that involve characteristics of the people with disabilities. In contrast, this research focuses on the less researched demand side issue of the socio-cultural context. In addition, it responds to the “limited systematic research examining and comparing how country-related factors shape the treatment of persons with disability” (Beatty et al., 2019, p. 122).
Governance requirements in supply chain finance: the need for a dual-layered semipermeable boundary
Authors: Phraknoi Nichapa , Stevenson Mark , Jia Meng 
Published: April 2024

PurposeThe purpose of this study is to define and investigate the governance requirements of supply chain finance (SCF).Design/methodology/approachA qualitative analysis of 849 news articles published in UK newspapers (2000–2022) using the Gioia method.FindingsSCF governance relies on developing capacities for reflexive scrutiny at two stages: (1) prior to entering into an SCF relationship and (2) during its operation. Based on the notion of SCF as a complex adaptive system, we theorise SCF governance requirements as a dual-layered semipermeable boundary. The semipermeability of the two layers allows for a dynamic exchange between the SCF system and its environment. The first layer is the capacity to selectively enable or control the entry and access of certain actors and practices into the SCF system. The second layer is a capacity for ongoing scrutiny of the SCF operation and its development. Further, we identify five aspects of governance to be enabled, i.e. enhancing adaptability, building confidence, improving efficiency, advancing technology and promoting transparency; and four aspects to be controlled, i.e. preventing abuse of power, curbing fraud risk, constraining operational risk and restricting risky extensions to SCF practices.Practical implicationsOur dynamic framework can guide supply chain (SC) members in making decisions about whether to participate, or continue to operate, in an SCF relationship. Moreover, the findings have implications for policymakers and authorities who oversee entry/access and the involvement of SCF providers, particularly, fintech firms.Originality/valueThe study contributes to both the SC and governance literature by providing a systematic analysis of what SCF governance has to accomplish. Our novel contribution lies in its analysis of SCF governance based on a complex adaptive system approach, which expands the existing literature where SCF is described in rather static terms. More specifically, it suggests a need for a dynamic duality of SCF governance through the semipermeable boundary that selectively enables and controls certain SCF actors and practices.
Reinforming memes: a literature review of the status of memetic information
Authors: Smith Alexander O. , Hemsley Jeff , Tacheva Zhasmina Y. 
Published: April 2024

PurposeOur purpose is to reconnect memetics to information, a persistent and unclear association. Information can contribute across a span of memetic research. Its obscurity restricts conversations about “information flow,” the connections between “form” and “content,” as well as many other topics. As information is involved in cultural activity, its clarification could focus memetic theories and applications.Design/methodology/approachOur design captures theoretical nuance in memetics by considering a long standing conceptual issue in memetics: information. A systematic review of memetics is provided by making use of the term information across literature. We additionally provide a citation analysis and close readings of what “information” means within the corpus.FindingsOur initial corpus is narrowed to 128 pivotal memetic publications. From these publications, we provide a citation analysis of memetic studies. Theoretical directions of memetics in the informational context are outlined and developed. We outline two main discussion spaces, survey theoretical interests and describe where and when information is important to memetic discussion. We also find that there are continuities in goals which connect Dawkins’s meme with internet meme studies.Originality/valueTo our knowledge, this is the broadest, most inclusive review of memetics conducted, making use of a unique approach to studying information-oriented discourse across a corpus. In doing so, we provide information researchers areas in which they might contribute theoretical clarity in diverse memetic approaches. Additionally, we borrow the notion of “conceptual troublemakers” to contribute a corpus collection strategy which might be valuable for future literature reviews with conceptual difficulties arising from interdisciplinary study.
The contradictory effect of lean and industry 4.0 synergy on firm performance: a meta-analysis
Authors: Biondo Diego , Kai Dalton Alexandre , Pinheiro de Lima Edson , Benitez Guilherme Brittes 
Published: April 2024

PurposeWhile previous operations management literature acknowledges the positive influence of Lean and Industry (I4.0) on performance, recent studies examining the synergy between these two factors have produced inconsistent and contradictory results. Therefore, this study aims to provide a comprehensive understanding of the effect of Lean and I4.0 synergy on firm performance.Design/methodology/approachThis study utilised a meta-analysis approach, examining 23 empirical studies exploring multiple effects of the Lean and I4.0 synergy on firm performance. Multiple subgroup analyses were conducted to assess the contradictory outcomes and identify in what conditions such synergy may achieve performance.FindingsThe results affirm the prevailing positivist perspective among most scholars regarding the positive influence of the Lean and I4.0 synergy on firm performance. However, the overall effect size derived from the studies indicates a weak relationship, suggesting that this synergy alone is not the sole determinant factor of firm performance. In addition, the subgroup analyses reveal the presence of contingent conditions that may affect the performance outcomes when integrating Lean and I4.0, as most effects exhibit a weak relationship.Originality/valueThis study represents the first meta-analysis investigating the relationship between the Lean and I4.0 synergy on firm performance. By shedding light on the contradictory effects often depicted in the operations management literature, this study provides a critical reflection for researchers who tend to adopt an overly optimistic view of such synergy.
Time perspectives and collaborative performance in creative tasks
Authors: Auer Thorsten , Hoppe Julia Amelie , Thommes Kirsten 
Published: April 2024

PurposeThe relationship between variation in time perspectives and collaborative performance is scarcely explored, and even less is known about the respective mechanisms that lead to varying task performance. Thus, we aim to further the literature on time perspectives and collaborative performance, shedding light on the underlying behavioral patterns.Design/methodology/approachWe report a quasi-experiment analyzing the impact of past, present and future orientation variation in dyads (N = 76) on their quantitative and qualitative performance when confronted with a simple incentivized creative task with constraints. Subsequently, we offer a qualitative analysis of comments given by the participants after the task on the collaboration.FindingsResults indicate that a dyad's elevation of past orientation and diversity in future orientation negatively affect collaborative performance. At the same time, there is a positive effect of elevation of future orientation. The positive effect is driven by clear communication and agreement during the task, while the negative effect arises from work sharing and complementation.Practical implicationsThis study provides insights for organizations on composing individuals regarding their temporal focus for collaborative tasks that should be executed rapidly and require creative solutions.Originality/valueOur study distinguishes by considering the composition of past, present and future time perspectives in dyads and focuses on a creative task setting. Moreover, we explore the mechanisms in the dyads with a substantial elevation of/diversity in future orientation, leading to their stronger/weaker performance.
A multi-stage integrated model based on deep neural network for credit risk assessment with unbalanced data
Authors: Wang Lu , Zheng Jiahao , Yao Jianrong , Chen Yuangao 
Published: April 2024

PurposeWith the rapid growth of the domestic lending industry, assessing whether the borrower of each loan is at risk of default is a pressing issue for financial institutions. Although there are some models that can handle such problems well, there are still some shortcomings in some aspects. The purpose of this paper is to improve the accuracy of credit assessment models.Design/methodology/approachIn this paper, three different stages are used to improve the classification performance of LSTM, so that financial institutions can more accurately identify borrowers at risk of default. The first approach is to use the K-Means-SMOTE algorithm to eliminate the imbalance within the class. In the second step, ResNet is used for feature extraction, and then two-layer LSTM is used for learning to strengthen the ability of neural networks to mine and utilize deep information. Finally, the model performance is improved by using the IDWPSO algorithm for optimization when debugging the neural network.FindingsOn two unbalanced datasets (category ratios of 700:1 and 3:1 respectively), the multi-stage improved model was compared with ten other models using accuracy, precision, specificity, recall, G-measure, F-measure and the nonparametric Wilcoxon test. It was demonstrated that the multi-stage improved model showed a more significant advantage in evaluating the imbalanced credit dataset.Originality/valueIn this paper, the parameters of the ResNet-LSTM hybrid neural network, which can fully mine and utilize the deep information, are tuned by an innovative intelligent optimization algorithm to strengthen the classification performance of the model.
Cyber-physical metaverse learning in cultural sustainable education
Authors: Lai Ying-Hsun , Lin Yu-Shan , Chang Yao-Chung , Chen Shih-Yeh 
Published: April 2024

PurposeEducation for sustainable development (ESD) is a developing educational concept that aims to achieve economic, social and environmental sustainability through education. Cultural sustainability education aims to cultivate awareness and protection of cultural assets, promote sustainable development and foster environmental responsibility. This study establishes a cyber-physical metaverse of cultural sustainability learning to cultivate students' motivation, multicultural identity, critical thinking and sustainability thinking.Design/methodology/approachIn this study, virtual reality (VR) and 3D printing technologies were utilized to create a cyber-physical metaverse learning environment. This learning environment is designed to allow elementary school children to learn about indigenous cultures and the architecture of slate houses, as well as socio-architectural issues. Learners will be able to experience first-hand the plight of the indigenous tribal areas and the exploration of related cultural knowledge.FindingsThe study collected pre- and post-test data through questionnaires, using covariates to analyze learners' perceptions of learning. The results of this study showed that cyber-physical metaverse learning environment had a significant impact on learning motivation, multicultural identity and sustainability thinking for culturally sustainable education. However, this study’s impact on critical thinking skills in students remains to be confirmed.Research limitations/implicationsThis is a quasi-experimental study of a single country’s elementary school children in the indigenous area, so its findings cannot be extrapolated to other areas or to learners of different ages.Originality/valueThis study introduces a framework for incorporating both virtual and real cultures to promote sustainable learning. The cyber-physical metaverse learning is used to supplement teaching activities to enhance learners' motivation in learning multicultural knowledge. Students were able to recognize and protect cultural assets, as well as emphasize the importance of sustainable development.