bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the lncRNA-miRNA-mRNA ceRNA network in lungs of miR-147 −/− mice
Authors: Zhang Nan , Song Gui-Yuan , Yu Qing-Hua , Fan Xin-Ming , Zhang Wen-Shuo , Hu Yong-Jian , Chao Tian-Zhu , Wu Yao-Yao , Duan Shu-Yan , Wang Fei , Du Rui-Peng , Xu Ping 
Published: March 2024

Background: Previous studies have documented important roles for microRNA-147 (miR-147) in inflammation, radiation-induced injury, cancer, and a range of other diseases. Murine lungs exhibit high levels of miRNA, mRNA, and lncRNA expression. However, very little research to date has focused on the lncRNA-miRNA-mRNA competing endogenous RNA (ceRNA) networks associated with miR-147, and the regulation of lncRNAs and miRNAs in this setting remains poorly understood.Methods: After establishing a miR-147−/− model mouse, samples of lung tissue were harvested for RNA-sequencing, and differentially expressed lncRNAs, miRNAs, and mRNAs were identified. The miRNA targets of these lncRNAs and the identified miRNAs were first overlapped to facilitate the prediction of target mRNAs, with analyses then examining the overlap between these targets and mRNAs that were differentially expressed. Then, these target mRNAs were subjected to pathway enrichment analyses. These results were ultimately used to establish a miR-147-related ceRNA network.Results: Relative to wild-type mice, the lungs of miR-147−/− mice exhibited 91, 43, and 71 significantly upregulated lncRNAs, miRNAs, and mRNAs, respectively, together with 114, 31, and 156 that were significantly downregulated. The lncRNA-miRNA-mRNA network established based on these results led to the identification of Kcnh6 as a differentially expressed hub gene candidate and enabled the identification of a range of regulatory relationships. KEGG pathway enrichment showed that the mRNA targets of differentially expressed lncRNAs and miRNAs in the mice were associated with tumor-related signaling, endometrial cancer, bladder cancer, and ErbB signaling.Conclusion: These results suggest that the identified ceRNA network in miR-147−/− mice shapes tumor-associated signaling activity, with miR-147 potentially regulating various lncRNAs and miRNAs through Kcnh6, ultimately influencing tumorigenesis. Future studies of the lncRNA, miRNA, and mRNA regulatory targets shown to be associated with miR-147 in the present study may ultimately lead to the identification of novel clinically relevant targets through which miR-147 shapes the pathogenesis of cancer and other diseases.
On the impact of mass screening for SARS-CoV-2 through self-testing in Greece
Authors: Gilmour Samuel , Sapounas Spyros , Drakopoulos Kimon , Jaillet Patrick , Magiorkinis Gkikas , Trichakis Nikolaos 
Published: March 2024

BackgroundScreening programs that pre-emptively and routinely test population groups for disease at a massive scale were first implemented during the COVID-19 pandemic in a handful of countries. One of these countries was Greece, which implemented a mass self-testing program during 2021. In contrast to most other non-pharmaceutical interventions (NPIs), mass self-testing programs are particularly attractive for their relatively small financial and social burden, and it is therefore important to understand their effectiveness to inform policy makers and public health officials responding to future pandemics. This study aimed to estimate the number of deaths and hospitalizations averted by the program implemented in Greece and evaluate the impact of several operational decisions.MethodsGranular data from the mass self-testing program deployed by the Greek government between April and December 2021 were obtained. The data were used to fit a novel compartmental model that was developed to describe the dynamics of the COVID-19 pandemic in Greece in the presence of self-testing. The fitted model provided estimates on the effectiveness of the program in averting deaths and hospitalizations. Sensitivity analyses were used to evaluate the impact of operational decisions, including the scale of the program, targeting of sub-populations, and sensitivity (i.e., true positive rate) of tests.ResultsConservative estimates show that the program reduced the reproduction number by 4%, hospitalizations by 25%, and deaths by 20%, translating into approximately 20,000 averted hospitalizations and 2,000 averted deaths in Greece between April and December 2021.ConclusionMass self-testing programs are efficient NPIs with minimal social and financial burden; therefore, they are invaluable tools to be considered in pandemic preparedness and response.
Current methodologies of greenspace exposure and mental health research—a scoping review
Authors: Freymueller Julius , Schmid Hannah-Lea , Senkler Ben , Lopez Lumbi Susanne , Zerbe Stefan , Hornberg Claudia , McCall Timothy 
Published: March 2024

IntroductionGreenspaces can provide an important resource for human mental health. A growing body of literature investigates the interaction and the influence of diverse greenspace exposures. In order to gain a comprehensive understanding of the complex connection between greenspace and mental health, a variety of perspectives and methodological combinations are needed. The aim of this review is to assess the current methodologies researching greenspace and mental health.MethodsA scoping review was conducted. Four electronic databases (Pubmed, Embase, PsycInfo, Web of Science) were searched for relevant studies. A wide range of greenspace and mental health keywords were included to provide a comprehensive representation of the body of research. Relevant information on publication characteristics, types of greenspaces, mental health outcomes, and measurements of greenspace exposure and mental health was extracted and assessed.Results338 studies were included. The included studies encompassed a multitude of methods, as well as outcomes for both greenspace and mental health. 28 combinations were found between seven categories each for greenspace and mental health assessment. Some pairings such as geoinformation systems for greenspace assessment and questionnaires investigating mental health were used much more frequently than others, implying possible research gaps. Furthermore, we identified problems and inconsistences in reporting of greenspace types and mental health outcomes.DiscussionThe identified methodological variety is a potential for researching the complex connections between greenspace and mental health. Commonly used combinations can provide important insights. However, future research needs to emphasize other perspectives in order to understand how to create living environments with mental health benefits. For this purpose, interdisciplinary research is necessary.
Animal welfare at German abattoirs: insights into the occurrence of violations against laws and regulations from official veterinarians and judicial decisions
Authors: Schneidewind Stephanie Janet , Langforth Susann , Meemken Diana 
Published: March 2024

IntroductionThis study investigated the occurrence of various animal welfare violations at German abattoirs by analyzing the results of an anonymous online survey and relevant German court decisions.MethodsThe survey targeted official veterinarians (OVs) and other individuals responsible for enforcing animal welfare laws and regulations at German abattoirs. Participants were asked to report the five most common animal welfare violations in their workplaces during the past 3 years (2019–2021), and whether 22 specific given violations had occurred or not (in the same timeframe). The court decisions were examined to determine how many abattoirs were penalized for a specific animal welfare violation and the details about the number and species of affected animals.ResultsOverall, the violations examined throughout this study fell into one of the following categories: (1) use of prohibited driving aids (e.g., illicit use of electric prods, or hitting/beating animals); (2) inadequate husbandry in lairage; (3) inappropriate handling of animals with special care needs; (4) improper restraint, stunning, and bleeding of animals; and (5) unqualified task execution/inadequate administrative work (e.g., documentation of a violation). The violations analyzed in the scope of this study most frequently fell into categories 1, 2, and 4. Regarding the five violations that survey participants reported to be the most common in the years 2019–2021, 42.6% of responses (N = 277 reported violations) fell into category 4, followed closely by category 1 with 37.9%. Of the 22 violations surveyed in the second part of the survey, those reported by 50.0% or more participants were concentrated in categories 1, 2, and 4. Regarding the 16 relevant court rulings spanning from 2015 to 2022, the most frequently documented instances of misconduct primarily fell into category 1.DiscussionThe collected data suggest that there may be need for improvements regarding compliance with animal welfare legislation, especially concerning categories 1, 2, and 4. The authors suggest OVs to consider these findings when conducting monitoring activities at abattoirs and in the training and education of abattoir personnel.
Rapid hearing threshold assessment with modified auditory brainstem response protocols in dogs
Authors: Stanger Axel , Buhmann Gesine , Dörfelt Stefanie , Zablotski Yury , Fischer Andrea 
Published: March 2024

IntroductionAuditory brainstem response (ABR) is the gold standard for hearing testing in dogs. ABR is commonly used in puppies to diagnose congenital sensorineural deafness. Long test times limit the use for a more comprehensive hearing screening in veterinary practice. This study aimed to establish a super-fast hearing screening protocol in dogs.MethodsHearing thresholds were routinely measured with a mobile device designed for newborn hearing screening in 90 dogs. We introduced modifications of the ABR protocol, e. g., a binaural test mode, higher stimulus rates, a broadband chirp stimulus, and an algorithm for automatic peak V detection in a stepwise fashion. Hearing thresholds were then measured with fast protocols utilizing either 30 Hz click or 90 Hz broadband chirp stimuli with 80, 60, 40, 30, 20, 10, 0 and −10 dBnHL stimulation intensities. Interrater reliability, agreement between click and chirp hearing thresholds and correlations with clinical characteristics of the dogs were assessed.ResultsUsing all innovations, the test time for hearing threshold assessment in both ears was reduced to 1.11 min (mean). The chirp stimulus accentuated both, peak V and the subsequent trough, which are essential features for judgement of the hearing threshold, but preceding peaks were less conspicuous. Interrater reliability and agreement between click and chirp hearing threshold was excellent. Dogs &gt;10 years of age and dogs with abnormal hearing score or otitis score had significantly higher hearing thresholds than younger dogs (p ≤ 0.001) or dogs without abnormalities (p &lt; 0.001).ConclusionThe results demonstrate that modifications in ABR protocols speed-up test times significantly while the quality of the recordings for hearing threshold assessment is maintained. Modified ABR protocols enable super-fast hearing threshold assessment in veterinary practice.
ANALISIS LINGKUNGAN KERJA DAN KETERLIBATAN PEGAWAI TERHADAP KINERJA PEGAWAI DI SATUAN POLISI PAMONG PRAJA (SATPOL PP) KABUPATEN LAHAT
Authors: Della Triska , Rismansyah Rismansyah , Mafra Nisa Ulul’ 
Published: March 2024

The purpose of this study was to find out the influence of the Work Environment and Employee Involvement on Employee Performance in the Civil Service Police Unit (Satpol PP) in Lahat Regency. The sampling method in this study used a purposive sampling method, which is the technique of determining the sample with consideration of certain criteria. The sample in this study was taken based on the number of Civil Servants (PNS) in the Civil Service Police Unit and the Lahat Regency Damkar, totaling 52 people. The data collection method used is questionnaires. The data analysis technique used in this study was Multiple Linear Regression, Correlation Analysis, Determination Analysis, hypothesis t-test, and hypothesis F-test with the help of SPSS 22 for Windows. The results of the study show that there is a significant influence partially and simultaneously between the Work Environment and Employee Involvement on Employee Performance in the Civil Service Police Unit (Satpol PP) of Lahat Regency.
Keywords: Work Environment; Employee Engagement; Employee Performance
THE IMPACT OF THE WORK ENVIRONMENT ON THE PRODUCTIVITY OF THE PASTRY DEPARTMENT EMPLOYEES AT THE APURVA KEMPINSKI BALI
Authors: Harefa Mega Hernawati , Siboro Lidia Berliana 
Published: March 2024

This research aims to analyze the impact of the work environment on employees in the Pastry Department of The Apurva Kempinski, Bali. A good work environment has been recognized as essential in increasing employee productivity. Employee productivity is a critical element in achieving organizational success. Therefore, companies often strive to create a conducive work environment to improve the quality of employee work. The research method used is descriptive and causal, with various data analysis techniques, including correlation tests, determination tests, and linear regression analysis. The analysis results show a robust positive relationship between the work environment and employee productivity, with a correlation coefficient of 0.732. These findings indicate that improving the work environment can positively impact employee productivity. This study provides an essential contribution to understanding the importance of a conducive work environment in increasing employee productivity in the hotel industry. Recommendations are recommended for similar companies to pay attention to and improve the work environment to increase employee productivity.
Keywords: Work Environment; Employee Productivity; Hospitality
ANALISIS PENERAPAN E-BILLING DALAM PENYETORAN PAJAK PADA SATUAN KERJA STASIUN GEOFISIKA GUNUNGSITOLI
Authors: Nainggolan Firmatogu , Bate'e Maria Magdalena , Waruwu Eliyunus 
Published: March 2024

This research analyzes how e-billing is implemented in paying taxes at the Stasiun Geofisika Gunungsitoli. The research method used a qualitative method with a descriptive approach. Primary data was obtained through interviews and secondary data was obtained from official documents, related literature, and other relevant information sources. The research results show that tax payments at the Stasiun Geofisika Gunungsitoli have implemented e-billing, payments are made at the Gunungsitoli Post Office using cash payments and there are still delays in tax deposits. There are several obstacles to implementing e-billing at the Stasiun Geofisika Gunungsitoli, which include not being able to carry out Internet banking transactions due to not having an Internet banking token, the Internet network being unstable or slow, long queues at the post office payment counter, ATM receipts/proof of payment are easily erased, and lack of socialization regarding tax e-billing. Based on these findings, this research recommends that the Stasiun Geofisika Gunungsitoli strive to accelerate the implementation of electronic payment transactions so that tax payments can be made more quickly and easily, can be done anywhere, and avoid delays in tax deposits. It is also necessary to better understand the regulations for paying taxes to avoid tax sanctions.
Keywords: E-billing; Tax Deposit; Electronic Tax Payment Application
FACTORS THAT INFLUENCE THE INTEREST OF GEN-Z MUSLIM CONSUMERS IN PURCHASING FOOD ON THE ONLINE FOOD SERVICE DELIVERY SYSTEM APPLICATION
Authors: Marliyah Marliyah , Yanti Nursantri , Rafli Mhd 
Published: March 2024

This study aims to determine the factors that influence Gen-Z Muslim consumer interest in making food purchases on the online food service delivery system application which is divided into three variables, namely product quality, price, and halal awareness. This study uses quantitative methods, and data collection techniques by distributing questionnaires and sample number in this study was 100 students at the State Islamic University of North Sumatra using purposive sampling techniques. The data were analyzed using multiple linear regression methods. The results of the study indicate that product quality and price have a significant effect on purchase intention, and halal awareness has no significant effect on purchase intention, and the results of the simultaneous test hypothesis show that product quality, price, and halal awareness simultaneously affect purchase intention.
Keywords : Product Quality ; Price ; Halal Awaraness ; Purchase Intention
TRANSFORMASI INOVASI MODEL BISNIS PADA UMKM BATIK PASCA PANDEMI COVID 19
Authors: Azhar Ratih Mukti , Evanthi Ayundha 
Published: March 2024

The pandemic phenomenon had a significant impact on small and medium-sized enterprises, compelling them to respond to the situation. Business Model Innovation (BMI) represents an innovation model suitable for the sustainability of small and medium-sized enterprises, particularly as the local SME situation deteriorated during the first two years of the COVID-19 pandemic, specifically in 2020-2021. The reconfiguration of business models has emerged as one of the alternatives for SMEs to overcome these challenges. The business model concept enables Small and Medium Enterprises (SMEs) to tackle dynamic business challenges. In reality, the alteration of Business Models (BMs) in SMEs varies across different organizations. This research aims to provide insights into the changes in BMs for SMEs following the pandemic, specifically within the batik industry, through the Integrated Marketing Communications (IMC) approach applied to various case studies. The method used in this research is descriptive qualitative through case studies with case selection using a purposive sampling approach, which is the MSME of the Batik Industry. The results of this study offer empirical information about the Business Model Innovation (BMI) of SMEs during the pandemic, which can serve as a foundation for further research in BMI, particularly concerning SMEs.
Keywords: Business Model Innovation; SMEs; Batik; Pandemic
PENGARUH VARIASI PRODUK DAN CITA RASA TERHADAP KEPUTUSAN PEMBELIAN SEBLAK TEKWAN KUAH MERAH PADA KEDAI SEBLAK PRABUMULIH
Authors: Septiana Indah , Robyardi Erfan , Salmah Ninin Non Ayu 
Published: March 2024

The purpose of this research is to find out how the influence of product variations, taste, and purchasing decisions at Kedai Seblak Prabumulih. This is a survey research with two independent variables of product variation, taste, and the dependent variable of purchasing decision. Data collection by distributing questionnaires to 99 respondents at Kedai Seblak Prabumulih. The obtained data was applied to the classical assumption test consisting of the normality test, multicollinearity test, heteroscedasticity test, multiple regression analysis, coefficient of determination, and hypothesis testing consisting of t-test and F-test. The result showed that partially there was a significant effect between the product variation and the taste on purchasing decisions. There is a significant influence between product variations and taste simultaneously on purchasing decisions at Kedai Seblak Prabumulih.
Keywords : Product Variation; Taste; Purchase Decision
Faire communauté en ligne
Authors: Glain Olivier , Goudet Laura Gabrielle 
Published: March 2024

Dans cet article, nous proposons d’examiner la façon dont le français cadien est utilisé sur un groupe Facebook par des locuteurs aux niveaux divers afin de négocier, discuter et délimiter leur appartenance à la communauté cadienne. En quoi le français devient-il le point de convergence des problématiques identitaires des membres d’un groupe de français cadiens en ligne ? Notre corpus est le groupe Facebook « Cajun French Virtual Table Française ». L’un des buts de ce groupe est de préserver la langue et la culture françaises qui font historiquement partie intégrante du sud de la Louisiane. Il apparaît toutefois que les représentations, voire l’imaginaire des utilisateurs du groupe, façonnent l’expression de cette langue-culture.
La condition communautaire
Authors: Bonnec Damien 
Published: March 2024

Dans les sociétés occidentales savantes, s’il est un modèle de communauté musicale, c’est bien celui de l’orchestre symphonique. Tel qu’il se développe à partir du xviiie siècle, l’orchestre symphonique s’offre comme un corps social à part entière. Au xixe siècle, porté par l’audace républicaine, il est érigé comme exemple modèle de la « nation » : les musiciens y travaillent en commun pour la bonne exécution de l’œuvre. Toutefois, ce corps social musicien semble répondre à l’organisation même des signes de la partition. L’existence du chef d’orchestre peut d’ailleurs apparaître comme l’allégorie de cette manière centralisatrice de penser le collectif qui se joue déjà dans la mise en place des signes musicaux. Partant d’une analyse de la verticalité et de l’autorité, cette contribution vise à conscientiser les implicites d’une musique qui suit une organisation très disciplinée et tente de penser une autre manière, pour la musique, de susciter l’organisation d’une communauté. C’est à travers l’opposition entre une organisation verticale et horizontale que peut se penser un nouveau type de « vivre-ensemble ».
L’urbain, la ville et la langue
Authors: Coupé Christophe 
Published: March 2024

Cette étude propose d’interroger la division nord/sud à Dublin dans une optique urbaine et linguistique afin de tenter de saisir de quelle manière les Dublinois se représentent la variation linguistique à l’œuvre dans leur ville et comment l’urbain – en tant que tissu social – influence leurs perceptions linguistiques.
PENINGKATAN PENGETAHUAN KADER TENTANG POSYANDU MELALUI PELATIHAN
Authors: Ernawati Yuli , Dewi Ika Mustika , Marsiyah Maria Margaretha , Sugiman Sugiman 
Published: March 2024

Latar Belakang: Posyandu merupakan salah satu bentuk Upaya Kesehatan Bersumberdaya Masyarakat (UKBM) yang dikelola dari, oleh, untuk, dan bersama masyarakat, guna memberdayakan masyarakat dan memberikan kemudahan kepada masyarakat dalam memperoleh pelayanan kesehatan dasar. Penelitian ini untuk mengetahui pengaruh pelatihan terhadap pengetahuan kader tentang posyandu balitaMetodologi : Desain penelitian quasi experiment dengan rancangan pre test-post test design. Penelitian dilakukan di Posyandu Balita di Dusun Pugeran, Maguwoharjo, Depok, Sleman, menggunakan data primer berupa kuesioner pengetahuan posyandu terhadap kader. Data dianalisis secara univariat dan bivariatHasil : Data menunjukkan sebelum diberikan pelatihan tentang posyandu balita pada pengetahuan kader sebesar 12.5; kemudian setelah pelatihan pengetahuan menjadi 16,0. Uji hipotesis didapatkan nilai p-value = 0,004; artinya ada perbedaan pengetahuan anatar pre test dengan post test setelah dilakukan kegiatan pelatihan.Kesimpulan: Pelatihan terbukti meningkatkan pengetahuan kader tentang posyandu Kata kunci: Posyandu, Pengetahuan, Pelatihan, Kader, Balita