bluuebunny/crossref_metadata_2025_split huggingface dataset:
Return to Work After Refractory Out‐of‐Hospital Cardiac Arrest in Patients Managed With or Without Extracorporeal Cardiopulmonary Resuscitation: A Nationwide Register‐Based Study
Authors: Gregers Emilie , Kragholm Kristian , Linde Louise , Mørk Sivagowry Rasalingam , Andreasen Jo Bønding , Terkelsen Christian Juhl , Lassen Jens Flensted , Møller Jacob Eifer , Laugesen Helle , Smerup Morten , Kjærgaard Jesper , Møller‐Sørensen Peter Hasse , Holmvang Lene , Torp‐Pedersen Christian , Hassager Christian , Søholm Helle 
Published: March 2024

Background
Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used for refractory out‐of‐hospital cardiac arrest (OHCA). However, survivors managed with ECPR are at risk of poor functional status. The purpose of this study was to investigate return to work (RTW) after refractory OHCA.

Methods and Results

Of 44 360 patients with OHCA in the period of 2011 to 2020, this nationwide registry‐based study included 805 patients with refractory OHCA in the working age (18–65 years) who were employed before OHCA (2% of the total OHCA cohort). Demographics, prehospital characteristics, status at hospital arrival, employment status, and survival were retrieved through the Danish national registries. Sustainable RTW was defined as RTW for ≥6 months without any long sick leave relapses. Median follow‐up time was 4.1 years. ECPR and standard advanced cardiovascular life support were applied in 136 and 669 patients, respectively. RTW 1 year after OHCA was similar (39% versus 54%;
P
=0.2) and sustainable RTW was high in both survivors managed with ECPR and survivors managed with standard advanced cardiovascular life support (83% versus 85%;
P
>0.9). Younger age and shorter length of hospitalization were associated with RTW in multivariable Cox analysis, whereas ECPR was not.

Conclusions
In refractory OHCA‐patients employed prior to OHCA, approximately 1 out of 2 patients were employed after 1 year with no difference between patients treated with ECPR or standard advanced cardiovascular life support. Younger age and shorter length of hospitalization were associated with RTW while ECPR was not.
All That Heaven Allows
Authors: Noble Christopher Isaac 
Published: March 2024

Abstract
In the last book of The Consolation of Philosophy, Boethius develops his solution to the problem of divine foreknowledge and free choice. Interpreters standardly hold that this problem and his solution to it presuppose causal indeterminism. In this paper, I argue that Boethius, following a Neoplatonist view found in Proclus, is a causal determinist and compatibilist and maintains that God’s providential knowledge ensures the occurrence of all the events he knows. This alternative interpretation offers a better fit with Boethius’s text and its historical antecedents and provides resources to address the main criticisms of his solution.
‘Something Completely New in Art’
Authors: Whitehouse Deja 
Published: March 2024

Abstract
According to writer and poet Charles Cammell (1890–1968), Aleister Crowley (1875–1947) believed that through his influence and guidance, he could significantly improve an artist’s nascent abilities. Crowley claimed success for the musical achievements of Leila Waddell (1880–1932), the poetry of Victor Neuburg (1883–1940) and the artistic talents of Frieda, Lady Harris, née Bloxam (1877–1962). In 1938, Crowley invited Harris to illustrate The Book of Thoth, his last major magical work, designating her “artist executant.” Their partnership extended far beyond the requirements of the Thoth Tarot paintings: not only did Harris become Crowley’s magical pupil; they formed a strong and enduring friendship that lasted to the end of Crowley’s life. Harris had already achieved moderate success as an artist, but Crowley showed her how she could express esoteric concepts in her paintings, thereby creating “something completely new in art” (Harris to Crowley, Letter, 10 December 1940). Harris’s correspondence with Crowley shows that she eagerly embraced his guidance, determined to manifest the Tarot images in accordance with his vision. At the same time, she applied the same techniques to her own works and came to the realisation that art was the true basis of her spiritual path. Using extracts from Crowley’s and Harris’s correspondence, Crowley’s diary entries, and examples of Harris’s artwork, this article will argue that in the case of Frieda Harris, Crowley did indeed draw out her nascent artistic skills, and in doing so, enabled her to manifest Tarot designs, which on his own admission, “any given card is something beyond anything I had ever contemplated” (Crowley to Harris, Letter, 25 January 1939).
Creating Imaginative Pauses with Sin
Authors: Fleeson Nathan E. 
Published: March 2024

Abstract
Oscar Wilde and Paul Cadmus both utilize their art to renegotiate how we imagine our relationship to sin within Catholicism. This article draws attention to resonances between their approaches by presenting a Wildean queer theological aesthetic as a framework to interpret Cadmus’s art. A Wildean framework utilizes the excesses of both Catholicism and queerness as a foil for each other to create pauses for the imagination in a culture and religious tradition that risks falling into mechanization. In the space of that excess, we are allowed to escape the trap of existence to live as Individuals, claiming sin as an excess that offers an imaginative pause out of mere existence. Applied to Cadmus, a Wildean framework focuses on how Cadmus’s works also engages queer and Catholic excess to renegotiate Catholic guilt around the body and instead see the body and its sin as a site to know the Self.
“Vastness and Profundity”
Authors: Garton-Gundling Kyle 
Published: March 2024

Abstract
Scholars have often struggled to define the boundaries between sublime and religious experiences, but research tends to agree that sublimity is rational while religious experience is non-rational. However, this view receives a challenge from key texts in science fiction. In the texts I examine, contrary to prevailing views, sublimity turns mystical, while new religions become rational. Furthermore, religion and sublimity relate uneasily, as opposite poles that are distinct from but necessary to one another, with different texts emphasizing one while marginalizing, but not erasing, the other. I explore four authors, two of whom—Arthur C. Clarke and Liu Cixin—emphasize sublimity while relegating religion, while the other two—Robert A. Heinlein and Octavia E. Butler—focus on a fictional religion while subordinating the sublime. Taken together, these texts reveal the ambivalent interdependence of rational and non-rational states of mind in ways that could promote better understanding between religious and non-religious perspectives.
The Most Perfect Book in the World
Authors: Peters William 
Published: March 2024

Abstract
As initially published by Aleister Crowley (1875–1947) in 1909, his book 777 contained tables of correspondences between the Tarot, qabalistic Tree of Life, divine pantheons and other aspects of Western esotericism. Unsatisfied with the original edition, in 1925 he commissioned artist Oskar Hopfer (1892–1966) to produce diagrams to illustrate the correspondences contained in the tables. Unfortunately, no publisher was found to issue the revised work, and the project went unfulfilled. Hopfer’s original work for Crowley is no longer extant. His designs were considered lost until the recent discovery of set of the diagrams in a German museum. This discovery has shed light on Crowley’s plans for the revised edition of 777, his attempts to publish the work, and his belief in the power of the visual arts to communicate complex esoteric principles.
Effects of Trauma Center Consolidation on Adult Trauma at a Rural Level 1 Trauma Center
Authors: Heard Matthew A. , Bray Sheree , Archer Allen , O'Quinn Payton C. , Wheeler Hannah , Leonard Matthew , Burns J. Bracken 
Published: March 2024

Objective The aim was to determine the impact of consolidation of two rural level 1 trauma centers on adult trauma patients presenting to the remaining level 1 trauma center. To our knowledge, a study assessing the impact of trauma center consolidation on adult trauma patients had yet to be performed. Methods A single institution, retrospective study was conducted at a rural level 1 trauma center. Adult trauma patients who presented to our center from January 2017 to January 2022 were included. The cohorts spanned 33 months pre- and post-consolidation. Multiple demographic and outcome measures were gathered. Data were analyzed using the student’s t-test and Chi-squared testing. Results There was a 33% increase in overall trauma activations and 9% increase in transfers from outside facilities post-consolidation. The post-consolidation group was significantly older, had higher mean injury severity score, and decreased hospital-free days. The post-consolidation group also saw an increase in ICU admission and surgical intervention. While there were no significant differences in ICU-free days or ventilator days, patients in the post-consolidation group with the highest level of activation who required both surgical intervention and ICU admission experienced decreased mortality. Conclusion The consolidation of trauma services to a single level 1 trauma center in a rural Appalachian health system led to higher trauma volume and acuity, but most importantly decreased mortality for the most severely injured trauma patients.
Modified elastic intramedullary nail internal fixation for distal tibial metaphyseal junction fracture
Authors: Liu Wanlin , Zhao Zhenqun , Bai Rui , Meng Chenyang 
Published: March 2024

Objective: To investigate the application of modified elastic intramedullary nail and the outcomes between modified elastic stable intramedullary nailing and traditional elastic stable intramedullary nailing in children with distal tibial metaphyseal junction fracture. Methods: A retrospective study was conducted. From January 2018 to January 2021, a total of 36 children with distal tibial metaphyseal junction fracture were treated in our hospital. All of them were treated with closed reduction and elastic stable intramedullary nailing internal fixation. A total of 18 children were treated by modified elastic stable intramedullary nailing and 18 children were treated by traditional elastic stable intramedullary nailing. Postoperative imaging, clinical efficacy, and complications were analyzed. Results: The mean follow-up time was 20 (15–36) months in modified group and 22 (16–33) months in traditional group. There were no complications such as infection, loss of reduction, and unequal length of lower limbs in modified group while loss of reduction occurred in two cases in traditional group. In these two cases of loss of reduction, we preformed manual reduction and replacement of long leg casts, and there was no loss of reduction, and the patient achieved a good prognosis. In the last follow-up, American Orthopaedic Foot & Ankle Society score was used. In modified group, excellent outcome achieved in 17 cases, good outcome achieved in 1 case, and satisfactory therapeutic effect was achieved. In traditional elastic stable intramedullary nailing group, excellent outcome achieved in 14 cases, and good outcome achieved in 4 cases. There was no statistical difference in the scores between the two groups. Conclusion: It was concluded that modified elastic stable intramedullary nailing fixation is a safe and effective treatment.
16S rRNA Gene-Based Microbiome Taxonomic Profiling for Evaluating the Effect of Mumefural on Fecal Microbiota in C57BL/6 Mice
Authors: Kim Jungim , Kim Min-Soo , Jeon Won Kyung 
Published: March 2024

Objectives Based on a report that Prunus mume fruits affect gut function and microflora, we hypothesized that mumefural (MF), one of the active compounds of processed Prunus mume fruits, could affect intestinal function or gut microbiome. Methods we investigated the effects of orally administered MF on intestinal function and the intestinal environment by analyzing the changes in the fecal, intestinal, and gut microbiome of a murine model. Results No changes in the body weight and fecal parameters of C57BL/6 mice were observed following MF administration. However, the quantity of residual feces in the large and small intestines and cecum was considerably reduced. The abundance of specific bacteria, ie, members of the Lactobacillus genus, was markedly increased without any change in the abundance or diversity of the gut microbiota, as determined by 16S rRNA gene-based microbiome taxonomic profiling. Conclusions Overall, our results suggest that oral MF administration could improve the gut microbiota in diseases related to specific bacterial changes because it increases the abundance of certain bacteria known to exhibit probiotic functions without any other obvious effects.
Development and Implementation of a Culturally Informed Spanish Language Yoga Program for Latiné Women With Overweight or Obesity Diagnosed With Cancer: A Single Arm Pilot Study
Authors: Victorson David , Guitelman Judy , Maletich Carly , Horowitz Bruriah , Sauer Christina , Arechiga Cailin , Parra Diana 
Published: March 2024

Background Given limited yoga research in health disparities populations, we developed and evaluated a 12-week Spanish language yoga program for Latiné women with overweight or obesity affected by cancer. The program aimed to empower participants through culturally tailored yoga practice and opportunities for social connection and support. Methods Partnering with a community-based organization, the program was co-created by bilingual (English and Spanish-speaking) yoga instructors, Latiné cancer survivor support professionals, and integrative medicine researchers. The single arm intervention consisted of 12 separate, 60-minute Hatha yoga classes, including physical postures, breathing exercises, culturally relevant poetry, and post-practice socialization opportunities. Measures were administered at baseline, 12-week, and 24-week. Results Thirty-five eligible participants enrolled in the program, demonstrating high feasibility and relevance as well as high levels of engagement in home practice. Some participants faced barriers to regular home practice, including family responsibilities and concerns about proper pose execution. Preliminary outcome analyses indicated improvements in sleep disturbance, pain interference, depression, and blood pressure post-intervention, with sustained improvements in depression, anxiety, and blood pressure at 24-week. No significant changes were observed in fatigue, physical function, positive affect, satisfaction with social roles and activities, and weight. Structured post-practice social snack time with yoga instructors (compared with unstructured time with peers) was associated with self-reported improvements in satisfaction with social roles and activities and weight loss. Conclusion This yoga program successfully engaged female Latiné cancer survivors with overweight and obesity and serves as a foundational step in empowering this population to improve their health and well-being through culturally tailored yoga practice. Future research should utilize controlled study designs and engage participants from different geographical regions to study the efficacy and sustainability of findings.
Performance optimization of novel multi-unit green wall system for blackwater treatment and reuse on-site
Authors: Wang Zhiquan , Xie Weijie , Shi Fan , Fan Chunzhen , Wu Suqing , He Shengbing , Kong Hainan , Zhao Min , Zheng Xiangyong 
Published: March 2024

AbstractBlackwater constitutes a primary component of environmental pollution posing serious risk to human health; however, reusing the nutrients found in blackwater diminishes the associated pollution and promotes resource recycling. Conventional green-wall systems are not suitable for in situ treatment of high-concentration wastewater. Thereby, a novel multi-unit green-wall system with six independent treatment units was designed to achieve a cost-effective and eco-friendly in situ treatment of blackwater with high organic load. Zeolite carriers were selected for the matrix with carrier depth of 14.5 cm, ivy and chlorophytum were selected as the greening plants. Various pollutants were rapidly reduced at the initial stage and the concentration of the pollutants decreased as the number of treatment units increased. Overall, the green-wall system was more effective in removing COD and NH4+–N with the removal rates of 98.5% and 98%, which may be due to the good buffering capacity of the media and the roles of Firmicutes and Bacteroidetes in COD degradation and ammoniated nitrification reactions. In addition, the maximum TP and TN removal rates were observed with a value of 85% and 42%, respectively. Consequently, the novel multi-unit green-wall system is an effective method for in situ blackwater reuse.
Graphical Abstract
Feature-specific quantile normalization and feature-specific mean–variance normalization deliver robust bi-directional classification and feature selection performance between microarray and RNAseq data
Authors: Skubleny Daniel , Ghosh Sunita , Spratlin Jennifer , Schiller Daniel E. , Rayat Gina R. 
Published: March 2024

Abstract
Background
Cross-platform normalization seeks to minimize technological bias between microarray and RNAseq whole-transcriptome data. Incorporating multiple gene expression platforms permits external validation of experimental findings, and augments training sets for machine learning models. Here, we compare the performance of Feature Specific Quantile Normalization (FSQN) to a previously used but unvalidated and uncharacterized method we label as Feature Specific Mean Variance Normalization (FSMVN). We evaluate the performance of these methods for bidirectional normalization in the context of nested feature selection.

Results
FSQN and FSMVN provided clinically equivalent bidirectional model performance with and without feature selection for colon CMS and breast PAM50 classification. Using principal component analysis, we determine that these methods eliminate batch effects related to technological platforms. Without feature selection, no statistical difference was identified between the performance of FSQN and FSMVN of cross-platform data compared to within-platform distributions. Under optimal feature selection conditions, balanced accuracy was FSQN and FSMVN were statistically equivalent to the within-platform distribution performance in multivariable linear regression analysis. FSQN and FSMVN also provided similar performance to within-platform distributions as the number of selected genes used to create models decreases.

Conclusions
In the context of generating supervised machine learning classifiers for molecular subtypes, FSQN and FSMVN are equally effective. Under optimal modeling conditions, FSQN and FSMVN provide equivalent model accuracy performance on cross-platform normalization data compared to within-platform data. Using cross-platform data should still be approached with caution as subtle performance differences may exist depending on the classification problem, training, and testing distributions.
Longer serum phosphorus time in range associated with lower mortality risk among peritoneal dialysis patients: a multicenter retrospective cohort study
Authors: Huo Zhihao , Liu Dehui , Ye Peiyi , Zhang Yuehang , Cao Lisha , Gong Nirong , Dou Xianrui , Ren Chengfa , Zhu Qingyao , Li Dan , Zhang Wei , Kong Yaozhong , Wang Guobao , Ai Jun 
Published: March 2024

Abstract
Background
Relationship between serum phosphorus time in range and mortality risk in peritoneal dialysis (PD) patients remains uncertain. We aimed to evaluate the association between serum phosphorus time in range and all-cause mortality in Chinese PD population.

Methods
This was a multicenter, retrospective, cohort study of 1,915 patients collected from January 2008 to October 2020 in 4 Chinese centers. Serum phosphorus time in range was estimated as the months during the first year that a patient’s serum phosphorus level was within the target range (defined as 1.13–1.78 mmol/L). The primary outcome was all-cause mortality. The secondary outcomes were cardiovascular (CV) mortality and PD withdrawal. Cox proportional hazards regression model with comprehensive adjustments was used to assess the association.

Results
The primary outcome occurred in 249 (13.0%) PD patients over a median follow-up of 28 months. Overall, the serum phosphorus time in range was negatively associated with all-cause mortality (per 3-month increments, adjusted HR [aHR], 0.83; 95%CI: 0.75–0.92), CV mortality (per 3-month increments, aHR, 0.87; 95%CI: 0.77–0.99), and PD withdrawal (per 3-month increments, aHR, 0.89; 95%CI: 0.83–0.95). Competing-risk model showed that the relationship of serum phosphorus time in range with all-cause mortality remained stable. None of the variables including demographics, history of diabetes and CV disease, as well as several PD-related and clinical indicators modified this association.

Conclusions
PD patients with longer serum phosphorus time in range in the first year was negatively associated with all-cause mortality and CV mortality. Our findings highlight the importance of maintaining serum phosphorus levels within 1.13–1.78 mmol/L for PD patients.
Clinical experiences of guided tapering of antipsychotics for patients with schizophrenia– a case series
Authors: Mølgaard Sofie Norlin , Nielsen Mette Ødegaard , Roed Kickan , Nielsen Jimmi 
Published: March 2024

Abstract
Background
80% of patients value information on treatment options as an important part of recovery, further patients with a history of psychotic episodes feel excluded from decision making about their antipsychotic treatment, and on top of that, mental health staff is prone to be reluctant to support shared decision making and medication tapering for patients with schizophrenia. This case series aims to demonstrate the tapering of antipsychotic medication and how guided tapering affects the patient’s feeling of autonomy and psychiatric rehabilitation.

Case presentation
We present six patients diagnosed with schizophrenia (International Classification of Mental and Behavioral Disorders– 10th Edition codes F20.0–5, F20.7–9) who underwent professionally guided tapering in our clinic. The clinic aims to guide the patients to identify the lowest possible dose of antipsychotic medication in a safe setting to minimise the risk of severe relapse. Two patients completely discontinued their antipsychotic medication, two suffered a relapse during tapering, one chose to stop the tapering at a low dose, and one patient with treatment resistant schizophrenia, which is still tapering down.

Conclusions
Reducing the antipsychotic dose increased emotional awareness in some patients (n = 4) helping them to develop better strategies to handle stress and increased feelings of recovery. Patients felt a greater sense of autonomy and empowerment during the tapering process, even when discontinuation was not possible. Increased awareness in patients and early intervention during relapse may prevent severe relapse.

Impact and implications
Some patients with schizophrenia might be over medicated, leading to unwanted side effects and the wish to reduce their medication. The patients in our study illustrate how guided tapering of antipsychotic medication done jointly with the patient can lead to improved emotional awareness and the development of effective symptom management strategies. This may in turn lead to a greater sense of empowerment and identity and give life more meaning, supporting the experience of personal recovery.