bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular imprinted polymers: important advances in biochemistry, biomedical and biotechnology
Authors: Önal Acet Burcu , İnanan Tülden , Salieva Kalipa , Borkoev Bakyt , Odabaşı Mehmet , Acet Ömür 
Published: March 2024

AbstractMolecularly imprinted polymers (MIPs) are handmade receptors that mimic the binding of natural antibodies. In other words, MIPs can selectively bind to the target molecule and qualify as bio-inspired synthetic materials. Today, MIPs are used extensively and are being developed further for biological applications. High cost and time consuming techniques are compelling factors for the field of biochemistry, biomedicine and biotechnology (3B), and there is an urgent need for an alternative, cheap, easy to produce, fast and effective method in these fields. MIPs stand out as a promising way for this purpose. MIPs have superiorities such as specific recognition specificity, excellent sensitivity selectivity and reusability. From this point of view, we examined MIP-related drug delivery studies, cell recognition, enzyme applications, in vivo applications, and applications for some important biomolecules. The aim of this review is to compile the utilizations, advantages, important developments and future expectations of MIPs for the fields of 3B.
Projecting Spring Consecutive Rainfall Events in the Three Gorges Reservoir Based on Triple-Nested Dynamical Downscaling
Authors: Zheng Yanxin , Li Shuanglin , Keenlyside Noel , He Shengping , Suo Lingling 
Published: March 2024

AbstractSpring consecutive rainfall events (CREs) are key triggers of geological hazards in the Three Gorges Reservoir area (TGR), China. However, previous projections of CREs based on the direct outputs of global climate models (GCMs) are subject to considerable uncertainties, largely caused by their coarse resolution. This study applies a triple-nested WRF (Weather Research and Forecasting) model dynamical downscaling, driven by a GCM, MIROC6 (Model for Interdisciplinary Research on Climate, version 6), to improve the historical simulation and reduce the uncertainties in the future projection of CREs in the TGR. Results indicate that WRF has better performances in reproducing the observed rainfall in terms of the daily probability distribution, monthly evolution and duration of rainfall events, demonstrating the ability of WRF in simulating CREs. Thus, the triple-nested WRF is applied to project the future changes of CREs under the middle-of-the-road and fossil-fueled development scenarios. It is indicated that light and moderate rainfall and the duration of continuous rainfall spells will decrease in the TGR, leading to a decrease in the frequency of CREs. Meanwhile, the duration, rainfall amount, and intensity of CREs is projected to regional increase in the central-west TGR. These results are inconsistent with the raw projection of MIROC6. Observational diagnosis implies that CREs are mainly contributed by the vertical moisture advection. Such a synoptic contribution is captured well by WRF, which is not the case in MIROC6, indicating larger uncertainties in the CREs projected by MIROC6.
Systemic glucocorticoid exposure and postoperative infection risk in 143,782 appendectomy patients—a Danish longitudinal nationwide study
Authors: Orgun Doruk , Nordestgaard Ask Tybjærg , Poulsen Henrik Enghusen , Gogenur Ismail , Ellervik Christina 
Published: March 2024

Abstract
Background
Glucocorticoids are conventionally associated with increased postoperative infection risk. It is necessary to clarify if preoperative glucocorticoid exposure is associated with postoperative infection in appendectomy patients and if the association is different for open and laparoscopic appendectomies.

Methods
A Danish nationwide study of appendectomy patients between 1996 and 2018. Exposures were defined as high (≥ 5 mg) versus no/low (< 5 mg) glucocorticoid exposure in milligram prednisone-equivalents/day preoperatively. The main outcome was any postoperative infection. Then, 90-day cumulative incidences (absolute risk) and adjusted hazard ratios (relative risk) of the outcome were calculated for high versus no/low glucocorticoid exposure within all appendectomies and within open and laparoscopic subgroups. Propensity-score matching was used for sensitivity analysis.

Results
Of 143,782 patients, median age was 29 years, 74,543 were female, and 7654 experienced at least one infection during the 90-day follow-up. The 90-day cumulative incidence for postoperative infection was 5.3% within the no/low glucocorticoid exposure group and 10.0% within the high glucocorticoid exposure group. Compared to no/low glucocorticoid exposure, adjusted hazard ratios for 90-day postoperative infection with high glucocorticoid exposure were 1.25 [95% CI 1.02–1.52; p = 0.03] for all appendectomies, 1.59 [1.16–2.18; p = 0.004] for laparoscopic appendectomies, and 1.09 [0.85–1.40; p = 0.52] for open appendectomies (pinteraction < 0.001). The results were robust to sensitivity analyses.

Conclusion
Preoperative high (≥ 5 mg/day) glucocorticoid exposure was associated with increased absolute risk of postoperative infections in open and laparoscopic appendectomies. The relative risk increase was significant for laparoscopic but not open appendectomies, possibly due to lower absolute risk with no/low glucocorticoid exposure in the laparoscopic subgroup.
BRAF/MEK-targeted therapy in BRAF ex15 p.T599dup mutation-driven NSCLC: a case report
Authors: Jiang Lan , Yang Pirong , Liu Yufeng , Li Juan 
Published: March 2024

AbstractBRAF mutations are found in 1–5% of non-small-cell lung cancer (NSCLC), with V600 and non-V600 accounting for approximately 50% each. It has been confirmed that targeted therapy with dabrafenib + trametinib is effective in patients with metastatic NSCLC carrying BRAF V600E mutations. Preclinical studies have shown that dabrafenib + trametinib may also have inhibitory effects on some types of non-V600E mutations, especially some class II BRAF mutations. However, the efficacy of dabrafenib + trametinib on non-V600E mutant NSCLC in clinical practice only exists in some case reports. Here, we report a case of NSCLC patient carrying BRAF ex15 p.T599dup, who showed a clinical response to the combined therapy of dabrafenib + trametinib.
Risk sharing rule and safety loading in a peer to peer cooperative insurance model
Authors: Clemente Gian Paolo , Levantesi Susanna , Piscopo Gabriella 
Published: March 2024

AbstractThe evolution of digital technologies is reshaping consumer habits and needs, driving process automation, and giving rise to innovative business models like Insurtech. Peer-to-peer (P2P) insurance is emerging as part of this trend. P2P involves purchasing an insurance policy by sharing the risk with a group of peers. This group transparently monitors real-time savings and tracks claims filed by its members. At the policy’s expiration, if the actual risk is lower than anticipated, the peers receive a partial refund of their premium. This paper introduces a model to determine the entry price in a broker-based P2P scheme using a cooperative game approach. We employ the Shapley Value method to distribute the risk among participants. Numerical examples are included for illustration and discussion.
Mentha piperita powder enhances the biological response, growth performance, disease resistance, and survival of Oreochromis niloticus infected with Vibrio alginolyticus
Authors: Abu-Zahra Nagwa I. S. , ElShenawy Abeer M. , Ali Gehan I. E. , Al-sokary Eman T. , Mousa Mohamed A. , El-Hady Hala A. M. Abd 
Published: March 2024

AbstractRecently, medical plants have been widely used as replacements for antibiotics in disease treatment. Because of its multiple medicinal uses, peppermint (Mentha piperita, MP) is a common herbal remedy. In the present study, MP powder was used as a feed additive to assess growth performance; hematological; biochemical and immune parameters; intestinal histology; and interleukin 1β (IL-1β) gene expression, as well as protection against Vibrio alginolyticus infection in Oreochromis niloticus. O. niloticus (n = 120, 25.66 ± 0.16 g) were fed diets containing 0 (CTR), 2, 3, or 4% MP for 60 days. The results revealed that the inclusion of 2% MP significantly improved the growth indices, intestinal morphological parameters, and reduced the feed conversion ratio. The 2% MP treatment significantly (P < 0.05) increased hematological parameters (red blood cell (RBC) count, white blood cell (WBC) count, packed cell volume% (PCV%), hemoglobin) compared with those of the CTR (P < 0.05). Additionally, feeding fish 2% MP diets decreased the levels of cholesterol and LDL (low-density lipoprotein). There were significant increases in immune responses (serum protein and phagocytic activity and index) and non-significant increases in the expression of IL-1β in the 2% MP group comparing with the other groups and the CTR group (P < 0.05). At the end of the feeding trial (60 days), fish were challenged with a virulent strain of Vibrio alginolyticus and the results showed that the mortality rate decreased in the 2% MP treatment group, followed by the 3% and 4% MP groups. Overall, the results revealed that the dietary inclusion of 2% MP can exhibit growth-promoting and immunostimulant effects for sustainable aquaculture.
Ethnic inequities in use of breast conserving surgery and radiation therapy in Aotearoa/New Zealand: which factors contribute?
Authors: Boyle Leah , Lawrenson Ross , Nosa Vili , Campbell Ian , Tin Tin Sandar 
Published: March 2024

Abstract
Purpose
Aotearoa/New Zealand (NZ) faces ethnic inequities with respect to breast cancer survival and treatment. This study establishes if there are ethnic differences in (i) type of surgery and (ii) receipt of radiotherapy (RT) following breast conserving surgery (BCS), among women with early-stage breast cancer in NZ.

Methods
This analysis used Te Rēhita Mate Ūtaetae (Breast Cancer Foundation National Register), a prospectively maintained database of breast cancers from 2000 to 2020. Logistic regression models evaluated ethnic differences in type of surgery (mastectomy or BCS) and receipt of RT with sequential adjustment for potential contributing factors. Subgroup analyses by treatment facility type were undertaken.

Results
Of the 16,228 women included, 74% were NZ European (NZE), 10.3% were Māori, 9.4% were Asian and 6.2% were Pacific. Over one-third of women with BCS-eligible tumours received mastectomy. Asian women were more likely to receive mastectomy than NZE (OR 1.62; 95% CI 1.39, 1.90) as were wāhine Māori in the public system (OR 1.21; 95% CI 1.02, 1.44) but not in the private system (OR 0.78; 95% CI 0.51, 1.21). In women undergoing BCS, compared to NZE, Pacific women overall and wāhine Māori in the private system were, respectively, 36 and 38% less likely to receive RT (respective OR 0.64; 95% CI 0.50, 0.83 and 0.62; 95% CI 0.39, 0.98).

Conclusion
A significant proportion of women with early-stage breast cancer underwent mastectomy and significant ethnic inequities exist. Modern guidelines encourage BCS + RT. In NZ, this outcome must be carefully monitored by ethnicity to facilitate equitable surgical management of early-stage breast cancer.
Effect of early dose reduction of osimertinib on efficacy in the first-line treatment for EGFR-mutated non-small cell lung cancer
Authors: Hori Tomoki , Yamamoto Kazuhiro , Ito Takefumi , Ikushima Shigeki , Omura Tomohiro , Yano Ikuko 
Published: March 2024

SummaryOsimertinib is used as the first-line therapy for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, early dose reduction is often required due to adverse events (AEs). This study aimed to evaluate the effect of early dose reduction of osimertinib on efficacy and safety. This was a retrospective study including patients with EGFR-mutated NSCLC who were started on osimertinib as the first-line therapy between August 2018 and December 2021. Patients whose doses were reduced to less than 80 mg/day within 6 months of osimertinib initiation or started at 40 mg/day were defined as the dose reduction group. The primary endpoint was progression-free survival (PFS). Factors affecting PFS were explored using the Cox proportional hazards model. A total of 85 patients were included in this study. No significant differences in patient characteristics were observed between the dose reduction (n = 25) and standard dose groups (n = 60). The median PFS in the dose reduction group was significantly prolonged compared with that in the standard dose group (26.0 months vs. 12.0 months, p = 0.03). Multivariable analysis of 84 patients, excluding a patient with unknown brain metastasis, revealed that EGFR exon 21 L858R mutation, malignant pleural effusion or pleural metastasis, liver metastasis, and dose reduction within 6 months were independent factors affecting PFS. Early dose reduction of osimertinib is an effective therapeutic strategy for prolonging PFS in patients with EGFR-mutated NSCLC.
I want to play a game: Examining sex differences in the effects of pathological gaming, academic self-efficacy, and academic initiative on academic performance in adolescence
Authors: Kristensen Sara Madeleine , Jørgensen Magnus , Haug Ellen 
Published: March 2024

AbstractAlthough research has investigated the association between pathological gaming and academic performance in adolescence, the complexity of the relationship has not been thoroughly examined. This short longitudinal study aimed to investigate the interactions between pathological gaming, academic self-efficacy, academic initiative, and academic performance in an adolescent sample, focusing on sex differences. The participants (N = 2853; 50.1% boys) were students in the second and third years of upper secondary school. Their grade point average (GPA) at graduation the same year was obtained. The moderated mediation structural equation model results showed that academic self-efficacy, directly and indirectly through academic initiative, impacted later GPA. There was no direct effect of pathological gaming on academic initiative or GPA. However, academic self-efficacy moderated the impact of pathological gaming on GPA for boys. In other words, boys with increased pathological gaming tended to achieve poorer grades in school if they experienced a strong academic self-efficacy. This study contributes to the understanding of the complex interplay between sex, pathological gaming, academic self-efficacy, academic initiative, and academic performance. We suggest that future research examines confidence or other relevant factors as explanatory mechanisms in the relationships between pathological gaming, academic self-efficacy, and GPA, particularly in male samples.
Characteristics of crack growth in brittle solids with the effects of material heterogeneity and multi-crack interaction
Authors: Wang Luyu , Yin Zhen-Yu , Chen Weizhong 
Published: March 2024

AbstractDespite the extensive research on crack propagation in brittle solids, numerous unexplored problems still necessitate in-depth study. In this work, we focus on numerical modeling of multi-crack growth, aiming to explore the effect of material heterogeneity and multi-crack interaction on this process. To do this, an improved singular-finite element method (singular-FEM) is proposed with incorporation of heterogeneity and crack interaction. An efficient algorithm is proposed for simulating multi-crack propagation and interaction. Stress singularity near crack tip is reproduced by the singular elements. The singular-FEM is convenient and cost-effective, as the zone far away from crack tips is directly discretized using linear elements, in contrast to the quadratic or transition elements utilized in traditional FEM. Next, the proposed method is validated through benchmark study. Numerical results demonstrate that the superiority of the singular-FEM, which combines the merits of low cost and high accuracy. Then, the mechanics of crack growth are explored in more complex scenarios, accounting for the effects of crack interaction, loading condition and heterogeneity on crack trajectory, stress field and energy release rate. The findings reveal that the combined effect of heterogeneity and crack interaction plays a critical role in the phenomenon of crack growth, and the proposed method is capable of effectively modeling the process.
Immobilization of radioactive sulphate waste simulate in polymer–cement composite based on recycled expanded polystyrene foam: evaluation of the final waste form resistance for Cs-134 and Co-60 leachability
Authors: Eskander Samir B. , Bayoumi Talat A. , Tawfik Magda E. 
Published: March 2024

AbstractThe present study investigates to incorporate spiked sulfate solution simulate into polymer–cement composite (PCC) based on recycled expanded polystyrene foam. The main aim is to convert the waste stream into leach resistance solid forms able to slow down or even to retard the back release of hazardous radionuclides to the surrounding. Effective parameters e.g. leachant medium, temperature, radioactivity contents, leachant volumes and radionuclides speciation versus the leaching time were studied. The incremental leach rate (Rn, cm/day) and the leach index (Lx) were evaluated for the final waste form after 145 days. The experimental results revealed that the Lx for the all variances can fulfil the waste acceptance criteria for the disposal facility and are above the threshold value of 6. Moreover, leach rate percentages for Cs-134 and Co-60 were not exceeding 2%. The acquired data, based on lab leaching experiments, can recommend the developed PCC under consideration for solidification of radioactive sulphate waste stream safely.
Can cross-domain term extraction benefit from cross-lingual transfer and nested term labeling?
Authors: Tran Hanh Thi Hong , Martinc Matej , Repar Andraz , Ljubešić Nikola , Doucet Antoine , Pollak Senja 
Published: March 2024

AbstractAutomatic term extraction (ATE) is a natural language processing task that eases the effort of manually identifying terms from domain-specific corpora by providing a list of candidate terms. In this paper, we treat ATE as a sequence-labeling task and explore the efficacy of XLMR in evaluating cross-lingual and multilingual learning against monolingual learning in the cross-domain ATE context. Additionally, we introduce NOBI, a novel annotation mechanism enabling the labeling of single-word nested terms. Our experiments are conducted on the ACTER corpus, encompassing four domains and three languages (English, French, and Dutch), as well as the RSDO5 Slovenian corpus, encompassing four additional domains. Results indicate that cross-lingual and multilingual models outperform monolingual settings, showcasing improved F1-scores for all languages within the ACTER dataset. When incorporating an additional Slovenian corpus into the training set, the multilingual model exhibits superior performance compared to state-of-the-art approaches in specific scenarios. Moreover, the newly introduced NOBI labeling mechanism enhances the classifier’s capacity to extract short nested terms significantly, leading to substantial improvements in Recall for the ACTER dataset and consequentially boosting the overall F1-score performance.
Multipath Attention and Adaptive Gating Network for Video Action Recognition
Authors: Zhang Haiping , Hu Zepeng , Yu Dongjin , Guan Liming , Liu Xu , Ma Conghao 
Published: March 2024

Abstract3D CNN networks can model existing large action recognition datasets well in temporal modeling and have made extremely great progress in the field of RGB-based video action recognition. However, the previous 3D CNN models also face many troubles. For video feature extraction convolutional kernels are often designed and fixed in each layer of the network, which may not be suitable for the diversity of data in action recognition tasks. In this paper, a new model called Multipath Attention and Adaptive Gating Network (MAAGN) is proposed. The core idea of MAAGN is to use the spatial difference module (SDM) and the multi-angle temporal attention module (MTAM) in parallel at each layer of the multipath network to obtain spatial and temporal features, respectively, and then dynamically fuses the spatial-temporal features by the adaptive gating module (AGM). SDM explores the action video spatial domain using difference operators based on the attention mechanism, while MTAM tends to explore the action video temporal domain in terms of both global timing and local timing. AGM is built on an adaptive gate unit, the value of which is determined by the input of each layer, and it is unique in each layer, dynamically fusing the spatial and temporal features in the paths of each layer in the multipath network. We construct the temporal network MAAGN, which has a competitive or better performance than state-of-the-art methods in video action recognition, and we provide exhaustive experiments on several large datasets to demonstrate the effectiveness of our approach.
The Sun’s Large-Scale Flows I: Measurements of Differential Rotation & Torsional Oscillation
Authors: Mahajan Sushant S. , Upton Lisa A. , Antia H. M. , Basu Sarbani , DeRosa Marc L. , Hess Webber Shea A. , Todd Hoeksema J. , Jain Kiran , Komm Rudolf W. , Larson Tim , Nagovitsyn Yury A. , Pevtsov Alexei A. , Roudier Thierry , Tripathy Sushanta C. , Ulrich Roger K. , Zhao Junwei 
Published: March 2024

AbstractWe have developed a comprehensive catalog of the variable differential rotation measured near the solar photosphere. This catalog includes measurements of these flows obtained using several techniques: direct Doppler, granule tracking, magnetic pattern tracking, global helioseismology, as well as both time-distance and ring-diagram methods of local helioseismology. We highlight historical differential rotation measurements to provide context, and thereafter provide a detailed comparison of the MDI-HMI-GONG-Mt. Wilson overlap period (April 2010 – Jan 2011) and investigate the differences between velocities obtained from different techniques and attempt to explain discrepancies. A comparison of the rotation rate obtained by magnetic pattern tracking with the rotation rates obtained using local and global helioseismic techniques shows that magnetic pattern tracking measurements correspond to helioseismic flows located at a depth of 25 to 28 Mm. In addition, we show the torsional oscillation from Sunspot Cycles 23 and 24 and discuss properties that are consistent across measurement techniques. We find that acceleration derived from torsional oscillation is a better indicator of long-term trends in torsional oscillation compared to the residual velocity magnitude. Finally, this analysis will pave the way toward understanding systematic effects associated with various flow measurement techniques and enable more accurate determination of the global patterns of flows and their regular and irregular variations.
Determination of dissociation constants of cephalosporin antibiotics by cellmetry method
Authors: Sadatsharifi Malek , Purgel Mihály 
Published: March 2024

Abstract
Acid dissociation constants of three cephalosporin antibiotics (cefapirin, ceftiofur, and cefotaxime) were calculated by a newly developed methodology. Plane-wave DFT calculations were performed to determine the pKa values, and by choosing the appropriate cell sizes, accurate values could be calculated. Some characteristic points were found which helped us to find correlations among the structural and physic-chemical parameters, and correlation factors were defined as well. This present study can be a base for further approaches to determining acid dissociation constants of cephalosporin molecules.

Graphical Abstract