bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Causal Relationship Between H2BC11/H2BC12 and Sepsis: A Bidirectional Two-Sample Mendelian Randomization Study
Authors: Wang Jie , Zhou Huili , Qian Xiaohan , Liu Qiuhong , Xia Qi , Cai Hongliu , Huang Lingtong , Wu Wei 
Published: March 2024

Abstract
Background
Sepsis is a critical medical condition involving with multi-organs. Recent studies hint at a potential link between increased serum histone levels and sepsis severity. However, conventional observational studies are prone to bias as reverse causation. In this study, we aimed to determine if there is a bidirectional causal link between histone levels and sepsis.
Methods
We applied Genome-wide association study (GWAS) and two-sample Mendelian randomization (MR) study to investigate the relationship. To ensure the reliability of our MR analysis, we also conducted the sensitivity analyses. Finally, we predicted drugs targeting H2BC11 and H2BC12 using available databases.
Results
After screening, we identified 4 of 16,972 H2BC11-related SNPs and 13 of 18,097 H2BC12 related SNPs associated with sepsis. Our forward MR analysis indicated that H2BC11 and H2BC12 (odds ratios (OR) > 1, p < 0.05) were risk factors for sepsis. Meanwhile, no causal relationship was observed between sepsis and H2BC11/H2BC12 (p > 0.05) in the reverse MR analysis. This sensitivity analysis confirmed the reliability of our MR analysis, providing confidence in our results. Furthermore, based on available databases, we identified a total of 78 drugs predicted to target H2BC11 and H2BC12.
Conclusion
Under mendelian randomization assumptions, our findings suggest H2BC11 and H2BC12 as the risk factors of sepsis and have identified potential treatments for this critical medical condition.
Hepatocellular carcinoma prevalence in cirrhotic patients and influencing factors in the North-West of Iran
Authors: Hamidzadeh Shokoufeh , Hosseiniazar Mohammadreza Mohammad , Roosta Yousef 
Published: March 2024

Abstract
Background
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, and it often develops in patients with underlying liver cirrhosis. The prevalence of HCC in cirrhotic patients is a significant concern, as it poses a high risk of morbidity and mortality. Aim of this study was Evaluating Hepatocellular carcinoma Prevalence in cirrhotic patients and influencing factors among patients admitted to Urmia Imam Khomeini Hospital ; North-West of Iran from 2016 to 2020.
Methods
This is a cross-sectional study. Data on hepatocellular carcinoma prevalence and cirrhotic influencing factors were collected from medical records of patients admitted to Imam Khomeini Hospital from 2016 to 2020.
Results
During the four-year study period, a total of 427 number of patients were admitted to Imam Khomeini Hospital with cirrhotic conditions. Mean (SD) of patients were 59.73(15.3) years. The diagnose rate of HCC was 10.77% (95% CI = 8–14%). HBV and HCV positivity were 26.1% (95% CI = 22–30%) and 6.1% (95% CI = 4–88%) among studied population respectively. HBV and HCV positivity were 63.04% (95% CI = 47–77%) and 10.86% (95% CI = 3.6–26%) among HCC respectively. Rate of reported alcohol consumption was 9.84% (95% CI: 7.18–13.06%). In cirrhotic patients, HBV and Cryptogenic cirrhosis were the most underlying disease among cirrhotic patients (26% and 18.7% of cases, respectively). HBV, Cryptogenic cirrhosis and alcoholic cirrhosis were the most underlying disease among in HCC patients (63% and 4.35% and 4.35% of cases, respectively).
Conclusions
The research highlights that liver cancer and hepatocellular carcinoma are not the most common cancers in this province, however due to the increasing trend of its predisposing factors and underlying diseases, It is important to have screening programs for people at high risk.
Primary CNS Lymphoma: age as a prognostic biomarker
Authors: Ohanyan Sona , Buxbaum Chen , Stein Polina , Ringelstein-Harlev Shimrit , Shelly Shahar 
Published: March 2024

Abstract

Background Lymphomatous involvement of the CNS incidence has been increasing in recent years. However, the rarity of these diseases results in a scarcity of available data regarding their clinical presentation natural history and prognosis. We aimed to investigate neurological characteristics of uncommon lymphomatous involvements confined to the central nervous system (CNS) and identify key variables that could serve as predictive biomarkers for treatment outcomes. Methods We searched for patients presenting with neurological symptoms and diagnosed with CNS-restricted lymphomatous involvement between 2005 and 2023. Results We identified 44 cases (41 with primary central nervous system lymphoma diagnosis, 93%; 3 intravascular lymphoma 7%). Overall median time from the onset of symptoms onset to diagnosis was 47 days: range (6-573 days) and was not statistically different comparing patients > 60 years old, p = 0.22. The median follow-up time was 1144 days (27-3501 days). Cognitive deterioration was the most common presenting symptom in 19/44 (43%). Brain MRI revealed lobar lesions as the most frequent location of pathology (24/44, 55%). Death was reported in 30 patients (68%) by the end of the study period with a median survival of 666 days; (median range 17-3291 days) and was significantly more common in the group experiencing relapses p = 0.04(CI: 0.99,0.03). Patients with relapses had a 4 times higher chance of death p = 0.04 (95% CI: 0.03–0.99) HR = 4.1 (CI 1.01–16.09). Time to diagnosis was associated with higher mortality, p = 0.04 (95% CI: 0.02–0.97) and survival p = 0.02 (95% CI: 0.005–0.54) as well with Eastern Cooperative Oncology Group at the last follow-up p = 0.006 (95% CI: 0.0012–0.62). Conclusions Patients had significant delays in diagnosis, affecting patient outcomes. Cognitive deterioration and lobar lesions were prominent clinical and radiological features. Mortality was notably higher in older patients, relapses, and a longer time to diagnosis.
Caregiver’s response to cardiorespiratory events in preterm infants in the NICU – a quantitative overview
Authors: Cramer Sophie Josephine Elisabeth , Zanten Henriette Anje van , Salverda Hylke Hendrik , Hooper Stuart Brian , Dekker Janneke , Pas Arjan Benedictus te 
Published: March 2024

Abstract
Purpose
Cardiorespiratory events in preterm infants form a major challenge in the Neonatal Intensive Care Unit (NICU) as they require a prompt response. We aimed to describe caregivers’ responses to these events.
Methods
We performed a prospective observational study using video recording of the inside of the incubator prompted by cardiorespiratory alarms in 19 preterm infants born at 28 weeks (± 2 weeks) gestational age receiving non-invasive respiratory support. Alarms were labelled as isolated or clustered, and subsequently classified as apnoea, bradycardia, desaturation and oxygenation events or a combination of these. Caregivers’ responses to these events were then identified from the videos.
Results
1851 cardiorespiratory events were recorded with a median duration of 11.0 (5.0-23.0) seconds. No response was observed in the majority of the events (91.5%). In the remaining 8.5% events, caregivers responded by pausing the alarm, adjusting devices and/or providing tactile stimulation with an average response time of 25.4 (13.8-35.9) seconds. Stimulation was the most observed response and was applied in 38 different ways. On average, stimulation lasted 18.7 (11.6-44.6) seconds and the cardiorespiratory events were resolved 30.6 (19.5-47.6) seconds after stimulation started.
Conclusions
Our study showed that cardiorespiratory events occur often in preterm infants in the NICU, but are most often not followed by intervention of the caregiver. The indication, timing and execution of responses to cardiorespiratory events is highly variable.
Cervicothoracic Ventral-Dorsal Rhizotomy for Treatment of Brachial Hypertonia in Cerebral Palsy
Authors: Abdelmageed Sunny , Dalmage Mahalia , Mossner James M. , Trierweiler Robin , Krater Tim , Raskin Jeffrey S. 
Published: March 2024

Abstract
Purpose
Cervicothoracic ventral-dorsal rhizotomy (VDR) is a potential treatment of medically refractory hypertonia in children who are not candidates for intrathecal baclofen, particularly in cases of severe upper limb hypertonia with limited to no function. A longitudinal cohort was identified to highlight our institutional safety and efficacy using cervicothoracic VDR for the treatment of hypertonia.
Methods
Retrospective data analysis was performed for children that underwent non-selective cervicothoracic VDR between 2022–2023. Non-modifiable risk factors, clinical variables, and operative characteristics were collected.
Results
6 patients (3 female) were included. Four patients underwent a bilateral C6-T1 VDR, one patient underwent a left C7-T1 VDR, and another underwent a left C6-T1 VDR. Three patients had quadriplegic mixed hypertonia, one patient had quadriplegic spasticity, one patient had triplegic mixed hypertonia, and one patient had mixed hemiplegic hypertonia. The mean difference of proximal upper extremity modified Ashworth scale (mAS) was − 1.4 ± 0.55 (p = 0.002), and − 2.2 ± 0.45 (p < 0.001) for the distal upper extremity. Both patients with independence noted quality of life improvements as well as increased ease with dressing and orthotics fits. Caregivers for the remaining four patients noted improvements in caregiving provision, mainly in dressing, orthotics fit, and ease when transferring.
Conclusion
Cervicothoracic VDR is safe, provides tone control and quality of life improvements in short-term follow-up. It can be considered for the treatment of refractory hypertonia. Larger multicenter studies with longer follow-up are necessary to further determine safety along with long-term functional benefits in these patients.
Vasculogenic Mimicry Related Long Noncoding RNA Signature Reveals New Therapy Strategy in Breast Cancer
Authors: Cao Yukun , Cao Jing , Zou Peng , Wang Shouman 
Published: March 2024

Abstract
Background
Vasculogenic mimicry (VM) is linked closely to the tumorigenesis. However, VM-related lncRNAs (VRLs) involved in the mediation of breast cancer (BC) are still unknown. This research aimed to identify a prognostic signature of VRLs in BC and excavate its potential biological function.
Methods
We obtained RNA-seq and relevant clinical data from The Cancer Genome Atlas database. Then, Cox and the LASSO regression were utilized to construct a multigene signature. The Kaplan-Meier and ROC curves were plotted to evaluate the efficacy of the model. GO and KEGG pathway were performed for patients in high-risk and low-risk groups. SsGSEA and CIBERSORT algorithm were used to observe the relationship in high-risk and low-risk groups and immune cells. Furthermore, we analysed the inhibitory concentration (IC50) values of three representative anti-vasculogenesis drugs of BC in high-risk and low-risk groups to verify drug sensitivity.
Results
A VRL-based prognostic signature composed by SEMA3B-AS1, MAPT-AS1, AL355512.1 and AP005717.2 was constructed. According to the risk score calculated by this signature, BC patients were divided into high-risk and low-risk groups. Patients in the high-risk group inclined to have a worse prognosis. SsGSEA and CIBERSORT showed that the majority of immune cells e.g., macrophage and CD4 T cell expressed notably higher in high-risk group (p < 0.05). In addition, we analysed the IC50 values of sorafenib, axitinib and AZD4547 in high-risk and low-risk groups, and all these drugs demonstrated favorable sensitivity to high-risk group which indicated that patients in high-risk group might benefit from anti-vasculogenesis drugs.
Conclusions
Based on bioinformatic analysis, we established a VM-related gene signature to predict the overall survival of BC patients. Apart from this, we characterized the relationship in the signature, immune microenvironment and correlated drugs which may ignite a novel idea of BC therapy.
Influence of Using Various Types of Steel Fibers of Recycled Concrete Aggregate on Shear Behavior of RC Beam son of interests
Authors: Summra Ayman Ahmed , Mahmoud Mahmoud Hassan , Soliman Mohamed Mahmoud 
Published: March 2024

Abstract
The goal of this research is to use recycled wastes such as recycled concrete aggregate and lathe waste in the concrete mix to reduce the cost of the concrete industry. The natural coarse aggregate (NCA) in the concrete mix was partially replaced using recycled concrete aggregate (RCA) by 30% with a target compressive strength of 30 MPa after 28 days by adding different types of fiber (steel fiber, recycled steel fiber and mixed fiber) with different percentages (1.0%, 1.5%, and 2.0%) to improve the behavior of different concrete mix. In this study, the mechanical properties and shear behavior of reinforced concrete beams of RCA by adding different types of fiber were investigated. Ten concrete mixtures were designed and ten reinforced concrete beams were tested under a two-point load to estimate the contribution of different types of fiber for shear resistance. The results show the effect of adding different types of fiber (steel fiber, recycled steel fiber and mixed fiber) that were used in concrete mixes was effective in improving and increasing the compressive, tensile, and flexural strength of concrete. Using different types of fiber for recycled concrete aggregate has improved the durability, ductility of concrete, and the ability of concrete to resist cracks due to the increase in shear resistance.
Genetic diversity analysis and germplasm identification of ‘ShiqianTaicha’ (Camellia sinensis var. sinensis) resources based on morphological traits and biochemical components
Authors: Lin Kaiqin , Wang Anrang , Li Yuexin , Li Lulu , Wei Jie , Zhou Fuyu , Liang Sihui , Yang Xiaowei , Zhao Degang , Yan Donghai 
Published: March 2024

Abstract
‘ShiqianTaicha’ is a historically famous tea, and was an important local populationvariety and has rich germplasm resources. To systematically evaluate the ‘ShiqianTaicha’ resources and identify excellent resources, we analyzed the morphological traits and biochemical components of 52 tea resources. The morphological traits and biochemical components of ‘ShiqianTaicha’ tea germplasm resources exhibit high genetic diversity. The coefficients of variation (CVs) of morphological traits of ‘Shiqian Taicha’ ranged from 7.95–45.67%, with an average of 28.37%, while H' ranged from 0.37 to 2.06, with an average of 1.02; the CVs of biochemical components ranged from 3.73–54.05%, with an average of 20.35%, while H' ranged from 1.21 to 2.09, with an average value of 1.86. Significant positive and negative correlations were observed between the morphological traits and biochemical components. PCA revealed that the total contribution rate of 14 traits, including leaf length, leaf width, leaf area, leaf tooth acuity, bud leaf color, water extract, tea polyphenols, total catechin and EGCG, was 81.05%, and these were the main factors influencing differences in tea tree resource morphological traits and biochemical components. Cluster analysis grouped the morphological traits and biochemical components into three main clusters and four main clusters, respectively.Based on the biochemical components, 25 resources with high levels of EGCG (≥ 10%), 2 resources with high levels of tea polyphenols (≥ 25%) and 4 resources with high levels of catechin (≥ 20%) were selected as excellent resources. These resources have the potential to be utilized in the cultivation of specific tea tree varieties with regional characteristics.
Relationship between preoperative nutritional status and postoperative complications in pediatric surgical patients
Authors: Agrawal Tripti , Saxena Rahul , Goel Akhil , Nayak Shubhalaxmi , Jadhav Avinash Sukdev , Rathod Kirtikumar , Pathak Manish , Sinha Arvind 
Published: March 2024

Abstract
AIM: To determine the relationship between preoperative nutritional status and postoperative complications in pediatric surgical patients.
METHODOLOGY: This prospective observational cohort study included 650 patients from 6 months to 18 years undergoing elective surgery at our institution. Nutritional status was standardized using Z-scores for weight, length, and BMI. Patients were monitored for a month following surgery to detect any complications, and they were classified into five grades using the Clavien-Dindo classification. The duration of hospital stays and readmission within 30 days following discharge were secondary outcomes.
RESULTS: There were 627 patients of both sexes involved in the study: 350 patients aged six months to 5 years (Group A), while 277 were aged between 5- 18 years (Group B). Wasting status was 47.71% in Group A and 41.52% in Group B. In Group A, 40 % of patients were stunted, while 83.75 % were in Group B. Group A had 57.14 % underweight patients. The complication rate was 39.14 % in Group A and 38.99% in Group B. The incidence of postoperative complications was not significantly different in malnourished patients. The patients with prolonged duration of surgery (> 2 hours) developed more complications in both groups (Group A – 67.2%, Group B – 82.6%; p < 0.0001). Also, the patients who experienced complications had lengthier hospital stays (p < 0.001 in both groups) and increased readmission rates (p = 0.016 in Group A and p = 0.008 in Group B).
CONCLUSION: In our study, Half of the patients in Group A and nearly 2/3rd in Group B were malnourished. The preoperative poor nutritional status based on anthropometric parameters is not associated with increased postoperative complications. Randomized control trials linking preoperative malnutrition based on anthropometric measures and clinical outcomes in pediatric surgery patients are necessary to provide more robust information on this subject.
Three-dimensional simulation of granular flow using a mesh-free numerical model
Authors: Kheirkhahan Mehran , Omidvar Pourya , Nikeghbali Pooyan , Pasereh Pouya , Nayyer Shahab 
Published: March 2024

Abstract
The study and modeling of granular materials using various rheological models are intriguing subjects in numerical simulations and are applicable for predicting and investigating the behavior of different materials, such as sand and granules, in various phenomena like dam breaks or dry landslides. In this paper, we conducted three-dimensional simulations of column collapses with limestone and sand using the μ(I) rheological model within the SPH framework. To assess the performance of the developed code, we compared experimental and numerical values of the free surface of granular particles at different time intervals. The results demonstrated that the numerical modeling error is less than five percent. Additionally, we compared particle dispersion conditions at different time points, indicating the high accuracy of the developed code. Therefore, the code developed for three-dimensional conditions, incorporating the μ(I) rheological model, can be effectively applied to similar phenomena.
Insufficient duration of insecticidal efficacy of Yahe insecticide-treated nets in Papua New Guinea
Authors: Bubun Nakei , Anetul Evodia , Koinari Melanie , Johnson Petrina H. , Makita Leo S. , Freeman Timothy W. , Robinson Leanne J. , Laman Moses , Karl Stephan 
Published: March 2024

Abstract
Background:Insecticide-treated nets (ITNs) are the backbone of antimalarial vector control in Papua New Guinea (PNG). Over recent years it was recognised that the quality and performance of ITNs has been decreasing, which is likely contributing to the stagnation in the malaria control effort in PNG. Here, we present results from the first 24 months of a durability study with the ITN product Yahe LN® in PNG.
Methods: The durability study was conducted in four villages on the northern coast of PNG, in an area with high malaria transmission, following WHO-recommended methodologies adapted to the local scenario. A cohort of individually identifiable Yahe ITNs were distributed by the PNG National Malaria Control Program from October to December 2021. Insecticidal efficacy of the ITNs was tested using cone bioassays at baseline and at 6 months intervals, alongside evaluation of physical integrity and the proportion of ITNs lost to follow-up. Questionnaires were used to collect information on ITN end user behaviour such as the frequency of use and washing.
Results: We observed gradual uptake and replacement of previous campaign nets by the communities such that at 6 months 45% of all newly distributed nets were in use in their designated households. Insecticidal efficacy of the Yahe nets, expressed as the percent 24h mortality of fully pyrethroid susceptible colony mosquitoes, decreased from 91% to 45% within the first 6 months of distribution, even though >90% of study nets had never been washed. Insecticidal efficacy decreased further to <20% at 24 months. ITNs accumulated physical damage (holes) at a rate similar to previous studies, and 35% were classified as too torn by 24 months. ITNs were lost to follow-up such that 61% of campaign nets were still present at 24 months. Wash resistance assays indicated rapid reduction in insecticidal performance with each consecutive wash such that 24h mortality was below 20% after 10 washes.
Discussion and Conclusion: Yahe ITNs are not performing as per label claim in an area with fully pyrethroid susceptible vectors and should be investigated more widely and in other settings. The mass distribution of low and variable quality ITN products is one of the major ongoing challenges for global malaria control in the last decade.
Robust Adaptive Nonlinear Admittance Control of Robotic Manipulators with Extra-Intra Uncertainties and Disturbances
Authors: Zhang Shubo , Chen Zhong , Zhang Xianmin 
Published: March 2024

Abstract

This paper focuses on achieving rapid convergence in finite time for robust trajectory tracking of robotic manipulators, which upper-bound uncertainties are unknown. To address the issues of excessive control torque and control reversal at the initial stage, a novel Robust Adaptive Fast Terminal Sliding Mode Control (RAF-TSMC) method is developed. The proposed method provides faster transient response, higher steady-state tracking accuracy, and can eliminate singularities and mitigate chattering effects. To enhance the physical collaboration in human-robot interactions, a novel Nonlinear Admittance Control method with RAF-TSMC is proposed, which benefits from adaptive compliance characteristics of Nonlinear Admittance Control with RAF-TSMC. This improves suppleness and flexibility of human-robot interaction in uncertain environments. Finally, the proposed controller is validated using a two-link robotic manipulator subjected to uncertainty and external forces. The results demonstrate that the proposed RAF-TSMC controller can effectively minimize tracking errors and convergence time, and the proposed Nonlinear Admittance Control with RAF-TSMC can enhances the flexibility and adaptability of the robot system.