bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cumulative Index of Exposure to Hypocarbia and Hyperoxia as Risk Factors for Periventricular Leukomalacia in Low Birth Weight Infants
Authors: Shankaran Seetha , Langer John C. , Kazzi S. Nadya , Laptook Abbot R. , Walsh Michele ,   for the National Institute of Child Health and Human Development Neonatal Research Network
Published: October 2006

BACKGROUND. Hypocarbia and hyperoxia are risk factors for periventricular leukomalacia in low birth weight infants. The association of a cumulative index of exposure to hypocarbia and hyperoxia and periventricular leukomalacia has not been evaluated.OBJECTIVE. Our goal was to examine the relationship between cumulative index of exposure to hypocarbia and hyperoxia and periventricular leukomalacia during the first 7 days of life in low birth weight infants.METHODS. Blood gas results were recorded in 6-hour intervals among low birth weight infants in a prospective data registry. Cumulative index of exposure to hypocarbia was calculated as the difference between arterial carbon dioxide level and 35 mmHg multiplied by the time interval in hours for each 6-hour block in a 24-hour day for the first 7 days of life. Cumulative index of exposure to hyperoxia was calculated in the same manner for arterial oxygen level &gt;80 mm Hg. The relationship between exposure to hypocarbia, hyperoxia, and periventricular leukomalacia was examined in 778 infants with blood gas and cranial sonography data.RESULTS. Twenty-one infants had periventricular leukomalacia. Hypocarbia occurred in 489 infants and hyperoxia in 502 infants. Infants with periventricular leukomalacia were more likely to have a lower gestational age and to require delivery room resuscitation than those without periventricular leukomalacia. More infants in the highest quartile of exposure to hypocarbia had periventricular leukomalacia compared to those with no hypocarbia. Risk of periventricular leukomalacia was increased in infants with the highest quartile of exposure to hypocarbia after adjusting for maternal and neonatal variables, none to be associated with periventricular leukomalacia. Cumulative index exposure to hyperoxia was not related to periventricular leukomalacia.CONCLUSIONS. Cumulative exposure to hypocarbia and not hyperoxia was independently related to risk of periventricular leukomalacia in low birth weight infants.
Ultrasound Examination of Extensive Limb Swelling Reactions After Diphtheria-Tetanus-Acellular Pertussis or Reduced-Antigen Content Diphtheria-Tetanus-Acellular Pertussis Immunization in Preschool-Aged Children
Authors: Marshall Helen Siobhan , Gold Michael Steven , Gent Roger , Quinn Patrick John , Piotto Lino , Clarke Michelle Frances , Roberton Donal Muir 
Published: October 2006

OBJECTIVE. The aim of this study was to determine the site, extent, and resolution of tissue involvement when extensive limb swelling occurred in the injected limb for children who received diphtheria-tetanus-acellular pertussis or reduced-antigen content diphtheria-tetanus-acellular pertussis vaccine at 4 to 6 years of age.
METHODS. Children who had experienced an injection site reaction at 18 months of age were assigned randomly to receive an intramuscular injection of either reduced-antigen content diphtheria-tetanus-acellular pertussis vaccine or diphtheria-tetanus-acellular pertussis vaccine between 4 and 6 years of age. Children who developed extensive limb swelling were recruited for assessment by clinical examination; ultrasound studies of the affected and opposite (control) arms were performed 24 to 48 hours after immunization and 48 to 96 hours later.
RESULTS. Twelve children with extensive limb swelling were enrolled in the study. Ultrasound examinations demonstrated swelling of both the subcutaneous and muscle layers of the vaccinated arm. Ultrasound assessment showed that the swelling exceeded the clinical measurements of skin redness and swelling. Subcutaneous and muscle tissues expanded to 281% and 111% of the tissue thicknesses of the control arm, respectively. Repeat ultrasound examinations after 48 to 96 hours showed considerable resolution of muscle swelling, compared with subcutaneous tissue swelling. There was no significant difference in the extent of swelling detected between children who received diphtheria-tetanus-acellular pertussis vaccine and those who received reduced-antigen content diphtheria-tetanus-acellular pertussis vaccine.
CONCLUSION. Extensive limb swelling reactions after diphtheria-tetanus-acellular pertussis or reduced-antigen content booster immunizations involved swelling of subcutaneous and muscle tissues with swelling and duration more marked in subcutaneous tissue.
Pediatric Precursors of Adult Cardiovascular Disease: Noninvasive Assessment of Early Vascular Changes in Children and Adolescents
Authors: Groner Judith A. , Joshi Mandar , Bauer John A. 
Published: October 2006

BACKGROUND. Until recently, our understanding of the childhood antecedents of adult cardiovascular disease was limited mainly to autopsy studies and pathologic findings in teens and young adults who died from accidental causes. Recent advances in the understanding of atherosclerosis and new technologies allowing detection of early events have made it possible to observe anatomic and physiologic evidence of cardiovascular disease in young adults and children.
OBJECTIVES. The goal of this article was to introduce pediatricians to new methods for noninvasive measurement of cardiovascular disease and its precursors, to describe the potential application of these techniques in detecting childhood precursors of adult cardiovascular disease, and to summarize knowledge gained from this approach.
METHODS. We conducted a computerized search of peer-reviewed articles listed in PubMed and Medline from 1980 to April 2006. We reviewed 63 and 84 articles from the adult and pediatric literature, respectively.
RESULTS. Reviewing the research on childhood antecedents of adult cardiovascular disease is sobering. Vascular alterations in anatomy, physiology, mechanical properties, and proinflammatory and prothrombotic changes are present from a very early age of childhood and are associated with the risk factors common in adult cardiovascular disease. At the same time, this body of research supports the concept that the vascular impairment from childhood may improve over time with appropriate intervention.
CONCLUSIONS. The measurement tools and concepts described in this article offer diagnostic and therapeutic opportunities for collaboration between clinical pediatricians and pediatric researchers. These partnerships will enable pediatricians to contribute in an effort to reduce the burdens of cardiovascular disease to individuals, families, and society.
Bullying and Peer Victimization Among Children With Special Health Care Needs
Authors: Van Cleave Jeanne , Davis Matthew M. 
Published: October 2006

BACKGROUND. Dr Van Cleave’s current address is Department of Pediatrics, Center for Child and Adolescent Health Policy, MassGeneral Hospital for Children, 50 Staniford St, Room 901, Boston, MA 02114. The association between bullying, being bullied, or being a bully/victim and having a special health care need has not been well described in a national sample of children with a broad variety of special needs.OBJECTIVE. We aimed to determine the prevalence of bullying, being bullied, or being a bully/victim in children with special health care needs and associations of behaviors with particular types of special needs.DESIGN. We performed a secondary data analysis using the National Survey of Children's Health, a nationally representative telephone survey conducted by the National Center for Health Statistics of &gt;102000 US households.METHODS. We measured associations between having a special health care need and being a victim of bullying, bullying other children, and being a bully/victim in children and adolescents aged 6 to 17 years. Multiple logistic-regression models were used to examine the association of children with special health care needs overall, and of particular special needs, with the bullying measures.RESULTS. Overall, children with special health care needs were 21% of the population. In multivariate models adjusting for sociodemographic factors, being a child with special health care needs was associated with being bullied but not with bullying or being a bully/victim. Having a chronic behavioral, emotional, or developmental problem was associated with bullying others and with being a bully/victim.CONCLUSIONS. Having a special health care need generally is associated with being bullied, and having a behavioral, emotional, or developmental problem is associated with bullying others and being a bully/victim. These findings may help pediatricians, mental health providers, and schools use targeted screening and interventions to address bullying for children with special health care needs.
Comparison of Outcome Measures for a Traditional Pediatric Faculty Service and Nonfaculty Hospitalist Services in a Community Teaching Hospital
Authors: Boyd John , Samaddar Kristen , Parra-Roide Lilia , Allen Edith Prieto , White Bruce 
Published: October 2006

OBJECTIVE. Several studies have found decreased cost and length of stay for patients who are cared for by pediatric hospitalists compared with traditional faculty models. The objective of this study was to compare cost and length of stay between a faculty group and 2 separate hospitalist groups in a community teaching hospital. This study differs from previous ones in that both the traditional faculty and hospitalist models were in place simultaneously, and the traditional faculty group was employed by the hospital, whereas the hospitalist groups were in private practice.
METHODS. A total of 1009 pediatric patients with any of the 11 most frequent diagnosis-related groups were analyzed according to the admitting physician group. Total direct costs and length of stay were computed for 3 separate groups (faculty group, hospitalist group 1, and hospitalist group 2). Linear regression models were used to compare total direct costs and length of stay among the groups. Each model accounted for age, severity index, and payer source.
RESULTS. Age, severity index, and physician group were predictive in determining total direct costs and length of stay. There was no significant difference in patient age among the groups, but the faculty group had significantly increased severity indices compared with hospitalist groups 1 and 2 (1.6 ± 0.7 vs 1.3 ± 0.6 vs 1.4 ± 0.6, mean ± SD). The faculty group had statistically significantly lower total direct costs compared with hospitalist groups 1 and 2 ($1781 ± $1449 vs $1954 ± $1212 vs $1964 ± $1495, mean ± SD). The faculty group had shorter average length of stay compared with hospitalist groups 1 and 2 (2.6 ± 2.0 vs 3.1 ± 2.6 vs 2.9 ± 2.3, mean ± SD). The readmission rates among the groups were similar.
CONCLUSIONS. Traditional faculty models can be as efficient in terms of total direct costs and length of stay as evolving hospitalist models. This study's results may be unique because the traditional faculty model was composed of general pediatricians instead of a blend of generalists and subspecialists. In addition, the traditional faculty physicians concentrated almost entirely on the care of inpatients while engaged in hospital care.
Evaluation of Resident Communication Skills and Professionalism: A Matter of Perspective?
Authors: Brinkman William B. , Geraghty Sheela R. , Lanphear Bruce P. , Khoury Jane C. , Gonzalez del Rey Javier A. , DeWitt Thomas G. , Britto Maria T. 
Published: October 2006

OBJECTIVE. Evaluation procedures that rely solely on attending physician ratings may not identify residents who display poor communication skills or unprofessional behavior. Inclusion of non-physician evaluators should capture a more complete account of resident competency. No published reports have examined the relationship between resident evaluations obtained from different sources in pediatric settings. The objective of this study was to determine whether parent and nurse ratings of specific resident behaviors significantly differ from those of attending physicians.
METHODS. Thirty-six pediatric residents were evaluated by parents, nurses, and attending physicians during their first year of training. For analysis, the percentage of responses in the highest response category was calculated for each resident on each item. Differences between attending physician ratings and those of parents and nurses were compared using the signed rank test.
RESULTS. Parent and attending physician ratings were similar on most items, but attending physicians indicated that they frequently were unable to observe the behaviors of interest. Nurses rated residents lower than did attending physicians on items that related to respecting staff (69% vs 97%), accepting suggestions (56% vs 82%), teamwork (63% vs 88%), being sensitive and empathetic (62% vs 85%), respecting confidentiality (73% vs 97%), demonstrating integrity (75% vs 92%), and demonstrating accountability (67% vs 83%). Nurse responses were higher than attending physicians on anticipating postdischarge needs (46% vs 25%) and effectively planning care (52% vs 33%).
CONCLUSIONS. Expanding resident evaluation procedures to include parents and nurses does enhance information that is gathered on resident communication skills and professionalism and may help to target specific behaviors for improvement. Additional research is needed to determine whether receiving feedback on parent and nurse evaluations will have a positive impact on resident competency.
The Impact of Public Insurance Expansions on Children’s Access and Use of Care
Authors: Duderstadt Karen G. , Hughes Dana C. , Soobader Mah-J , Newacheck Paul W. 
Published: October 2006

OBJECTIVE. Our goal was to examine the impact of the State Children’s Health Insurance Program nationally on children’s access and use of health care.OBJECTIVE. Our data source was the National Health Interview Survey, using 1997 as a baseline, which predates the implementation of the State Children’s Health Insurance Program, and 2003 as the end point of the analysis. We analyzed 25 734 children aged 0 to 18 years (1997 and 2003 combined) to examine changes in health insurance coverage rates, health care access, and utilization for children in the State Children’s Health Insurance Program target population, defined here as those living in families with incomes between 100% and 199% of the federal poverty level.RESULTS. Children in the State Children’s Health Insurance Program target income group showed the largest reduction in rates of uninsurance among 3 income groups (&lt;100%, 100%–199%, and ≥200% of the federal poverty level) between 1997 and 2003 (15.1%–8.7%). Significant reductions occurred in the proportion of children without a usual source of care in the target income group (9.4%–7.3%) and in the proportion of children without a provider visit in the past year (10.8%–9.8%). Other measures (unmet needs, delayed care, volume of provider visits, receipt of well-child care, and dental care) showed no significant changes over this time period. A separate multivariate analysis restricted to the State Children’s Health Insurance Program target population in 2003 showed that children with continuous public coverage had significantly better access and utilization on all measures studied when compared with uninsured children and performed as well or better than children with continuous private coverage.CONCLUSIONS. Implementation of the State Children’s Health Insurance Program is associated with substantial gains in public coverage for children in the target income group. Although some of these gains were offset by losses in private coverage, our findings demonstrate that public health insurance provides significant benefits in terms of access and utilization for children living in the target income group.
Factors Associated With Establishing a Causal Diagnosis for Children With Cardiomyopathy
Authors: Cox Gerald F. , Sleeper Lynn A. , Lowe April M. , Towbin Jeffrey A. , Colan Steven D. , Orav E. John , Lurie Paul R. , Messere Jane E. , Wilkinson James D. , Lipshultz Steven E. 
Published: October 2006

OBJECTIVE. The goal was to identify the clinical variables associated with establishing a cause of cardiomyopathy in children.METHODS. The Pediatric Cardiomyopathy Registry contains clinical and causal testing information for 916 children who were diagnosed as having cardiomyopathy in North America between 1990 and 1995. Children with a causal diagnosis were compared with those without with respect to several demographic, clinical, and causal testing variables.RESULTS. Cardiomyopathy was 1 of 4 types, hypertrophic (34.2%), dilated (53.8%), restrictive (3.2%), or other or mixed (8.9%). Only one third of cases had a known cause. Children with a known cause for hypertrophic cardiomyopathy were more likely to be female, to be relatively smaller, to present with congestive heart failure, and to have increased left ventricular posterior wall thickness without outflow tract obstruction. For dilated cardiomyopathy, a known cause was associated with older age, lower heart rate, smaller left ventricular dimensions, and greater shortening fraction. Family history of cardiomyopathy predicted a significantly higher rate of causal diagnoses for all cardiomyopathy types, whereas family histories of genetic syndromes and sudden death were also predictive of a cause for hypertrophic and dilated cardiomyopathies. For hypertrophic cardiomyopathy, only blood and urine testing was associated with a causal diagnosis, whereas both viral serologic testing or culture and endomyocardial biopsy were independent predictors of a causal diagnosis in dilated cardiomyopathy.CONCLUSIONS. Certain patient characteristics, family history, echocardiographic findings, laboratory testing, and biopsy were associated significantly with establishing a cause of pediatric cardiomyopathy. Early endomyocardial biopsy should be considered strongly for children with dilated cardiomyopathy, for definitive diagnosis of viral myocarditis. Although not widely used, skeletal muscle biopsy may yield a cause for some patients with hypertrophic cardiomyopathy and for patients suspected of having a mitochondrial disorder.
Population-Based Study of the Impact of Childcare Attendance on Hospitalizations for Acute Respiratory Infections
Authors: Kamper-Jørgensen Mads , Wohlfahrt Jan , Simonsen Jacob , Grønbæk Morten , Benn Christine Stabell 
Published: October 2006

OBJECTIVES. It is well known that children attending childcare have a higher risk of acute respiratory infections compared with children in home care; however, knowledge is sparse regarding how the excess risk of acute respiratory infection varies with age, time since enrollment, and other factors.METHODS. A national register-based study of 138821 inpatient admissions to hospital for acute respiratory infection during 3982925 person-years of follow-up in Danish children aged 0 to 5 years. Data on child and family characteristics, childcare attendance, and hospitalizations were obtained from Danish registries. The outcome of the study was inpatient admissions to hospital for acute respiratory infection. Incidence rate ratios were estimated using Poisson regression.RESULTS. In children &lt;1 year of age, the first 6 months of enrollment in the first childcare facility were associated with a 69% higher incidence of hospitalizations for acute respiratory infection compared with children in home care. Similar figures for children aged 1, 2, and ≥3 years were 47%, 41%, and 8%, respectively. The incidence decreased after the first 6 months, and after ≥1 year in childcare the incidence was comparable with that of children in home care. Similar patterns were seen after second enrollment. For 0- to 2-year-old children living in households with no additional children &lt;5 years, the excess incidence during the first 6 months of enrollment was 100% compared with 25% and 9% for children living with 1 and ≥2 additional children, respectively.CONCLUSIONS. The increased risk of acute respiratory infection was most pronounced among 0- to 2-year-old children living with no other children during the first 6 months of enrollment. Our findings may suggest that it would be optimal to postpone enrollment into childcare until after 1 year of age.
Achieving Family and Provider Partnerships for Children With Special Health Care Needs
Authors: Denboba Diana , McPherson Merle G. , Kenney Mary Kay , Strickland Bonnie , Newacheck Paul W. 
Published: October 2006

BACKGROUND. During the past 2 decades, family-centered care has evolved as the standard of care for children with special health care needs. A major principle of family-centered care is a strong partnership between the family and provider, working together to address issues and barriers to accessing comprehensive care and related services. The federal Maternal and Child Health Bureau defines a positive family-provider partnership as a core program outcome. Our objective was to assess the extent to which families of children with special health care needs feel as though they are treated as partners in decision-making by their doctors.
METHODS. We analyzed the 2001 National Survey of Children With Special Health Care Needs, a nationally representative telephone survey of caretakers for 38866 children with special health care needs. Bivariate and multivariate statistical methods were used to assess the frequency of meeting the partnership core outcome, as well as the demographic and socioeconomic predictors of meeting core outcome. We also examined the effect of partnership on indicators of access and well-being for children with special health care needs.
RESULTS. Among children with special health care needs, 85.8% of families reported usually or always feeling like a partner in their child's care. However, living in poverty, minority racial and ethnic status, absence of health insurance, and depressed functional ability placed children with special health care needs and their families at elevated risk of being without a sense of partnership. We found that sense of partnership was associated with improved outcomes across a number of important health care measures, including missed school days, access to specialty care, satisfaction with care, and unmet needs for child and family services.
CONCLUSIONS. Results of the survey demonstrated that whereas most families of children with special health care needs feel they are partners in the care of their child, further work is needed, particularly for poor, uninsured, and minority children, as well as those with functional limitations. The survey results also demonstrate the importance of partnership; children whose care met the partnership core outcome experienced improved access to care and well-being.