bluuebunny/crossref_metadata_2025_split huggingface dataset:
Duloxetine reduces opioid consumption and pain after total hip or knee arthroplasty: a meta-analysis of randomized controlled trials
Authors: Lin Yicai , Jiang Mingyang , Liao Chun , Wu Qingjian , Zhao Jinmin 
Published: March 2024

Abstract
Purpose
There is no consensus in the current literature on the analgesic role of duloxetine after total hip arthroplasty (THA) or total knee arthroplasty (TKA). Thus, we designed this meta-analysis to reveal the analgesic effectiveness and safety of duloxetine in TKA or THA.

Methods
As of October 2022, two authors (L.C. and W.Q.J.) independently searched five main databases (EMBASE, Web of Science, PubMed, Cochrane Library, and Google Scholar) to find relevant studies. Duloxetine vs. placebo in randomized controlled trials (RCTs) for THA or TKA were included. We set perioperative total opioid consumption as the primary outcome. Secondary outcomes included resting or dynamic pain scores over time, gastrointestinal adverse events, neurological adverse events, and other adverse reactions.

Results
Eight RCTs with 695 patients were incorporated in our study. This meta-analysis showed high evidence that duloxetine was effective in reducing perioperative opioid consumption (Standard mean difference [SMD] = − 0.50, 95% confidence intervals [CI]: −0.70 to − 0.31, P < 0.00001) and low to moderate evidence that duloxetine could reduce pain within three weeks after surgery. Low to high evidence showed no differences between the two groups for most adverse events. Substantial evidence suggests that duloxetine can reduce nausea and vomiting after surgery (Risk ratio [RR] = 0.69, 95% CI: 0.50 to 0.95, P = 0.02, I2 = 4%). However, moderate evidence suggested that duloxetine might be associated with increased postoperative drowsiness (RR = 1.83, 95% CI: 1.08 to 3.09, P = 0.02, I2 = 0%).

Conclusion
Duloxetine reduced overall opioid consumption in the perioperative period and relieved pain within three weeks after surgery without increasing the risk of adverse drug events. Duloxetine can be part of a multimodal management regimen in patients with THA and TKA.
Predictive value of preoperative platelet count and D-dimer levels for spinal cord injury following acute type a aortic dissection
Authors: Pei Fengbo , Wei Jinhua , Yao Yao , Wu Hui , Chen Zujun 
Published: March 2024

Abstract
Background
This study aims to identify the risk factors contributing to spinal cord injury (SCI) following a type A acute aortic dissection (TA-AAD).

Methods
This retrospective study was conducted at a single center and involved 481 patients who received frozen elephant trunk stent implantation for TA-AAD. Additionally, these patients underwent total arch replacement with deep hypothermic circulatory arrest. This study was performed at Fuwai Hospital between September 2016 and April 2020.

Results
The resulting data of the multivariate logistic regression analysis demonstrated that preoperative platelet count (odds ratio [OR] = 0.774) and D-dimer levels (OR = 2.247) could serve as independent predictors for postoperative SCI in patients with TA-AAD.

Conclusion
The findings indicate that preoperative platelet count and D-dimer levels are independent risk factors for postoperative SCI in patients with TA-AAD. This study holds significant clinical implications regarding the prognosis and therapeutic responses for patients with TA-AAD.
Axillary vein as an alternative venous access site for VV-ECMO cannulation: a case report
Authors: Pan Tao , Zhou Xiaoyang , Pan Jianneng , Chen Bixin , Xu Chang , Xu Zhaojun , Dong Pingping , Yu Tingting 
Published: March 2024

Abstract
Background
Ultrasound-guided percutaneous axillary vein cannulation can reduce cannulation failure and mechanical complications, is as safe and effective as internal jugular vein cannulation, and is superior to subclavian vein cannulation using landmark technique. As far, reports of venovenous extracorporeal membrane oxygenation (VV-ECMO) with percutaneous axillary vein cannulation are rare.

Case presentation
A 64-year-old man presenting with dyspnea and chest tightness after aspirating sewage was admitted to the emergency department. Computed tomography (CT) showed diffuse exudation of both lungs and arterial blood gas analysis showed an oxygenation index of 86. He was diagnosed with aspiration pneumonia-induced acute respiratory distress syndrome (ARDS) and intubated for deteriorated oxygenation. Despite the combination therapy of protective mechanical ventilation and prone position, the patient’s oxygenation deteriorated further, accompanied with multiple organ dysfunction syndrome, which indicated the requirement of support with VV-ECMO. However, vascular ultrasound detected multiple thrombus within bilateral internal jugular veins. As an alternative, right axillary vein was chosen as the access site of return cannula. Subsequently, femoral-axillary VV-ECMO was successfully implemented under the ultrasound guidance, and the patient’s oxygenation was significantly improved. Unfortunately, the patient died of hyperkalemia-induced ventricular fibrillation after 36 h of VV-ECMO running. Despite the poor prognosis, the blood flow during ECMO run was stable, and we observed no bleeding complication, vascular injury, or venous return disorder.

Conclusions
Axillary vein is a feasible alternative access site of return cannula for VV-ECMO if internal jugular vein access were unavailable.
Analysis of disease characteristics of a large patient cohort with congenital generalized lipodystrophy from the Middle East and North Africa
Authors: Al Yaarubi Saif , Alsagheir Afaf , Al Shidhani Azza , Alzelaye Somaya , Alghazir Nadia , Brema Imad , Alsaffar Hussain , Al Dubayee Mohammed , Alshahrani Awad , Abdelmeguid Yasmine , Omar Omneya M. , Attia Najya , Al Amiri Elham , Al Jubeh Jamal , Algethami Albandari , Alkhayyat Haya , Haleem Azad , Al Yahyaei Mouza , Khochtali Ines , Babli Saleha , Nugud Ahmed , Thalange Nandu , Albalushi Sarah , Hergli Nadia , Deeb Asma , Alfadhel Majid 
Published: March 2024

Abstract
Background
Congenital generalized lipodystrophy (CGL) is a rare inherited disease characterized by a near-total absence of adipose tissue and is associated with organ system abnormalities and severe metabolic complications. Here, we have analyzed the disease characteristics of the largest CGL cohort from the Middle East and North Africa (MENA) who have not received lipodystrophy-specific treatment.

Methods
CGL was diagnosed clinically by treating physicians through physical assessment and supported by genetic analysis, fat loss patterns, family history, and the presence of parental consanguinity. Data were obtained at the time of patient diagnosis and during leptin-replacement naïve follow-up visits as permitted by available medical records.

Results
Data from 43 patients with CGL (37 females, 86%) were collected from centers located in eight countries. The mean (median, range) age at diagnosis was 5.1 (1.0, at birth–37) years. Genetic analysis of the overall cohort showed that CGL1 (n = 14, 33%) and CGL2 (n = 18, 42%) were the predominant CGL subtypes followed by CGL4 (n = 10, 23%); a genetic diagnosis was unavailable for one patient (2%). There was a high prevalence of parental consanguinity (93%) and family history (67%) of lipodystrophy, with 64% (n = 25/39) and 51% (n = 20/39) of patients presenting with acromegaloid features and acanthosis nigricans, respectively. Eighty-one percent (n = 35/43) of patients had at least one organ abnormality; the most frequently affected organs were the liver (70%, n = 30/43), the cardiovascular system (37%, n = 16/43) and the spleen (33%, n = 14/43). Thirteen out of 28 (46%) patients had HbA1c > 5.7% and 20/33 (61%) had triglyceride levels > 2.26 mmol/L (200 mg/dl). Generally, patients diagnosed in adolescence or later had a greater severity of metabolic disease versus those diagnosed during childhood; however, metabolic and organ system abnormalities were observed in a subset of patients diagnosed before or at 1 year of age.

Conclusions
This analysis suggests that in addition to the early onset of fat loss, family history and high consanguinity enable the identification of young patients with CGL in the MENA region. In patients with CGL who have not received lipodystrophy-specific treatment, severe metabolic disease and organ abnormalities can develop by late childhood and worsen with age.
The clinical effectiveness of a self-management intervention for patients with persistent depressive disorder and their partners/caregivers: results from a multicenter, pragmatic randomized controlled trial
Authors: Solis Ericka C. , Carlier Ingrid V. E. , Kamminga Noëlle G. A. , Giltay Erik J. , van Hemert Albert M. 
Published: March 2024

Abstract
Background
Persistent depressive disorder (PDD) is prevalent and debilitating. For patients with PDD, psychiatric rehabilitation using self-management interventions is advised as the next therapeutic step after multiple unsuccessful treatment attempts. The “Patient and Partner Education Program for All Chronic Diseases” (PPEP4All) is a brief, structured self-management program that focuses on functional recovery for patients and their partners/caregivers. In chronic somatic disorder populations, PPEP4All has already been shown to be clinically effective. We examined whether PPEP4All adapted for PDD (PPEP4All-PDD, nine weekly group or individual sessions) is also clinically effective for adults/elderly with PDD and their partners/caregivers compared to care-as-usual (CAU) in specialized mental healthcare.

Methods
In this mixed-method multicenter pragmatic randomized controlled trial, 70 patients with PDD and 14 partners/caregivers were allocated to either PPEP4All-PDD (patients, n = 37; partners/caregivers, n = 14) or CAU (patients, n = 33; partners/caregivers, not included) and completed questionnaires at 0, 3, 6, and 12 months regarding depressive symptoms, psychopathology, psychosocial burden, mental resilience, and happiness/well-being. Qualitative data were collected regarding treatment satisfaction. Data were analyzed using mixed model analyses and an intention-to-treat (ITT) approach.

Results
There was no statistically significant difference in any outcome regarding clinical effectiveness between PPEP4All-PDD and CAU. Subgroup analysis for depressive symptoms did not show any interaction effect for any subgroup. Although 78% of participants recommended PPEP4All-PDD, there was no difference in treatment satisfaction between PPEP4All-PDD (score = 6.6; SD = 1.7) and CAU (score = 7.6; SD = 1.2), p = 0.06.

Conclusion
Although depressive symptoms did not improve relative to CAU, this only confirmed that treatment for patients with treatment-resistant PDD should move from symptom reduction to functional recovery. Also, functional recovery may be reflected in other outcomes than psychosocial burden, such as self-empowerment, in patients with treatment-resistant PDD. Future research on PPEP4All-PDD could focus on a longer-term program and/or online program that may also be offered earlier in the treatment process as an empowerment intervention.

Trial registration
Netherlands Trial Register Identifier NL5818. Registered on 20 July 2016 https://clinicaltrialregister.nl/nl/trial/20302
FLM-ICR: a federated learning model for classification of internet of vehicle terminals using connection records
Authors: Yang Kai , Du Jiawei , Liu Jingchao , Xu Feng , Tang Ye , Liu Ming , Li Zhibin 
Published: March 2024

AbstractWith the rapid growth of Internet of Vehicles (IoV) technology, the performance and privacy of IoV terminals (IoVT) have become increasingly important. This paper proposes a federated learning model for IoVT classification using connection records (FLM-ICR) to address privacy concerns and poor computational performance in analyzing users' private data in IoV. FLM-ICR, in the horizontally federated learning client-server architecture, utilizes an improved multi-layer perceptron and logistic regression network as the model backbone, employs the federated momentum gradient algorithm as the local model training optimizer, and uses the federated Gaussian differential privacy algorithm to protect the security of the computation process. The experiment evaluates the model's classification performance using the confusion matrix, explores the impact of client collaboration on model performance, demonstrates the model's suitability for imbalanced data distribution, and confirms the effectiveness of federated learning for model training. FLM-ICR achieves the accuracy, precision, recall, specificity, and F1 score of 0.795, 0.735, 0.835, 0.75, and 0.782, respectively, outperforming existing research methods and balancing classification performance and privacy security, making it suitable for IoV computation and analysis of private data.
Structural modeling of Chinese students’ academic achievement identity and basic psychological needs: do academic self-efficacy, and mindfulness play a mediating role?
Authors: Chen Shuya 
Published: March 2024

Abstract
Background
Mindfulness and academic self-efficacy were proposed as mediating variables, with successful academic identity as an exogenous variable. The backdrop for this research centers on the significance of psychological factors in shaping academic identity among college students.

Objectives
The primary aim of the research was to investigate the relationship between fundamental psychological needs, mindfulness, academic self-efficacy, and successful academic identity. Specifically, the study explored the direct and indirect impacts of basic psychological needs on successful academic identity mediated by mindfulness and academic self-efficacy.

Method
The research employed a descriptive method, utilizing correlational studies and structural equation modeling. A sample of 355 college students at Henan Judicial Police Vocational College, Henan, China, was randomly selected through multistage cluster sampling. Data were collected using established scales, including the Basic Psychological Needs Scale, Baer Mindfulness Scale, Jenkins and Morgan Academic Self-Efficacy Scale, and Vas and Isakson Successful Academic Identity Scale. The data analysis was conducted using AMOS 22 software.

Findings
The research findings revealed that fundamental psychological needs directly and indirectly significantly impact successful academic identity. Mindfulness played a mediating role in this relationship. However, academic self-efficacy did not considerably mediate the influence of fundamental psychological needs on successful academic identity (p > 0.05). These results highlight the complex dynamics between psychological needs, mindfulness, academic self-efficacy, and successful academic identity among college students in the specified academic year.

Conclusions
The findings suggest targeted interventions, such as workshops for families and teachers to address basic needs and psychologist and school counselor interventions to increase mindfulness. Additionally, organizing educational classes is imperative for fostering a supportive environment conducive to successful academic identity among college students.
Understanding the role of digital immersive technology in educating the students of english language: does it promote critical thinking and self-directed learning for achieving sustainability in education with the help of teamwork?
Authors: Tang Fenghua 
Published: March 2024

Abstract
Purpose
Universities are constantly searching for best practices to promote sustainability when it comes to educating students of the English language. Although this area of study has recently gained the attention of scholars around the world there is still a need to explore it from various perspectives.

Objective
This study aims to comprehensively investigate the impact of digital immersive technology on the education of English language students, specifically focusing on its potential to promote critical thinking and self-directed learning for achieving sustainability in education through teamwork. The research will assess the influence of digital immersive experiences on enhancing learning outcomes, examining their role in fostering critical thinking skills and encouraging self-directed learning practices. Additionally, the study explores the collaborative aspects of digital immersive technology, evaluating its contribution to teamwork among students.

Methodology
The objective was achieved by using a survey questionnaire to collect data from 304 registered students in various universities in Beijing. Data analysis was conducted by applying Mplus 7.0 software.

Findings
The findings revealed that the use of digital immersive technology was pivotal for achieving sustainable education both directly and indirectly to an extent. In addition, team working moderated all the respective paths except the path involving the use of digital immersive technology and critical thinking.

Implications
These results generated implications for teachers and policymakers to promote and facilitate the use of digital technology for teaching the English language to students, encouraging them to develop critical skills and self-directed learning strategies. The study also offered guidance and deeper understanding for researchers to address the concerns linked to the use of digital technology and sustainable education particularly in their future endeavors.
The effect of planning time on vocabulary acquisition in a task-based environment: the mediating roles of working memory and field (in)dependence
Authors: Gui Jingjing , Ismail Sayed M. 
Published: March 2024

AbstractThis research investigated the impact of planning time, working memory (WM), and cognitive styles on language learning outcomes within the framework of Task-Based Language Teaching (TBLT). Drawing on a diverse sample of language learners, the study employed a pretest-posttest control group quasi-experiment to examine the effects of providing pre-task planning time on language performance. Participants engaged in communicative tasks, with a focus on vocabulary acquisition and task complexity, while their cognitive processes were assessed through measures of WM and cognitive styles. The findings revealed significant interactions between planning time and cognitive styles, particularly field dependence, influencing language production and proficiency such that learners with planning time outperformed learners without planning time; high-WM learners outperformed their low-WM peers, and field independent learners outstripped their field-dependent counterparts. Moreover, the study contributes to the broader understanding of the nuanced relationship between planning time, WM, and cognitive styles in the context of TBLT. The implications of these findings for language teachers, materials developers, syllabus designers, curriculum developers, and policymakers are discussed, offering insights into the design of effective language learning environments. Despite certain limitations, the study provides a foundation for further research exploring cross-cultural variations, longitudinal effects, and the integration of technology in language education, with the aim of advancing pedagogical practices tailored to diverse learner profiles.
Arabic translation, content validity and reliability of the Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19)
Authors: Abou El-Maaty Ali Ahmed , El Sherifi Saad Shawki , El-Gilany Abdel-Hady , Zehry Hamada Ibrahim , Salim Almaza Ali , Rohiem Mahmoud F. , Ismael Ahmed Fawzi 
Published: March 2024

Abstract
Background
The prevalence of sexual dysfunction (SD) in multiple sclerosis (MS) patients is accounted to affect nearly 75% of them with higher rate in men than women. Though most of the patients may desire to discuss confidentially the SD with their physician, but both the physician and the patient usually hesitate to break into this presumed taboo. Assuming that MS affects about 35.9 per 100,000 population, it is clearly a problem of paramount significance not to find, to the best of our knowledge, a specific scale for assessing SD in MS patients who speak Arabic. We aimed to translate the Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19) from English into Arabic and then to Validate the Arabic version as a tool to evaluate the SD in MS patients.

Results
We included 40 (21 males and 19 females) sexually active married MS patients. Every patient completed the Arabic translation of the MSISQ-19. Validity construction was explored by the Cronbach's alpha coefficient and the exploratory factor analysis. The Arabic version of the scale was evaluated for clarity, relevance, and translation of the content. The SD represents 45.5% in our study (47.6% in males, 43.4% in females).

Conclusion
Through screening and diagnosis of SD in MS patients, MSISQ-19 would help both patients and physicians to invade the mystery of this hectic issue. In Arabic populations, Arabic version of MSISQ-19 could be a reliable, reproducible and validated tool for the targeting SD in MS patients.
The unweighed factor during assessment of systemic lupus erythematosus arthritis
Authors: Abdel-Moniem Omneya Mohamed-Ayman , Hassouna Sally S. 
Published: March 2024

Abstract
Background
Systemic lupus erythematosus (SLE) is a known multisystemic autoimmune disorder. Active disease causes diverse morbidities. Arthritis is one of disease features present in most of patients, so it is important to study risk factors for such a complaint. Obesity appeared in some studies to increase SLE activity, here in this study, and for the first time, the effect of body weight on arthritis associating the disease was assessed.

Methods
SLE patients were asked about their joint manifestations and were asked to weigh up joint pain severity which was translated into values of patient self-report joint count (PTJT) present in Multidimensional Health Assessment Questionnaire (MDHAQ), which was then compared to joint examination in the form of 28 tender joint count (28 TJC) and 28 swollen joint count (28 SJC). All previous items were correlated to body mass index (BMI).

Results
BMI has a significant positive correlation with PTJT p = 0.013, and when PTJT of upper limbs and lower limbs were assessed separately, BMI was also positively corelated with p = 0.008 and 0.049, respectively.

Conclusions
Increased BMI may be a risk factor for arthritis associated with SLE, regardless its effect on weight-bearing joints. Management of body weight may help in preventing progression of joint affection in SLE.