bluuebunny/crossref_metadata_2025_split huggingface dataset:
U‐Pb Age Determination for Seven Standard Zircons using Inductively Coupled Plasma–Mass Spectrometry Coupled with Frequency Quintupled Nd‐YAG (λ = 213 nm) Laser Ablation System: Comparison with LA‐ICP‐MS Zircon Analyses with a NIST Glass Reference Material
Authors: Orihashi Yuji , Nakai Shun’ichi , Hirata Takafumi 
Published: May 2008

AbstractThis paper evaluates the analytical precision, accuracy and long‐term reliability of the U‐Pb age data obtained using inductively coupled plasma–mass spectrometry (ICP‐MS) with a frequency quintupled Nd‐YAG (λ = 213nm) laser ablation system. The U‐Pb age data for seven standard zircons of various ages, from 28 Ma to 2400 Ma (FCT, SL13, 91500, AS3, FC1, QGNG and PMA7) were obtained with an ablation pit size of 30 μm diameter. For 207Pb/206Pb ratio measurement, the mean isotopic ratio obtained on National Institute of Standards and Technology (NIST) SRM610 over 4 months was 0.9105 ± 0.0014 (n = 280, 95% confidence), which agrees well with the published value of 0.9096. The time‐profile of Pb/U ratios during single spot ablation showed no significant difference in shape from NIST SRM610 and 91500 zircon standards. These results encouraged the use of the glass standard as a calibration standard for the Pb/U ratio determination for zircons with shorter wavelength (λ = 213 nm) laser ablation. But 206Pb/238U and 207Pb/235U ages obtained by this method for seven zircon standards are systematically younger than the published U‐Pb ages obtained by both isotope dilution–thermal ionization mass spectrometry (ID‐TIMS) and sensitive high‐resolution ion‐microprobe (SHRIMP). Greater discrepancies (3–4% younger ages) were found for the 206Pb/238U ages for SL13, AS3 and 91500 zircons. The origin of the differences could be heterogeneity in Pb/U ratio on SRM610 between the different disks, but a matrix effect accuracy either in the ICP ion source or in the ablation‐transport processes of the sample aerosols cannot be neglected. When the 206Pb/238U (= 0.2302) newly defined in the present study is used, the measured 206Pb/238U and 207Pb/235U ages for the seven zircon standards are in good agreement with those from ID‐TIMS and SHRIMP within ±2%. This suggests that SRM610 glass standard is suitable for ICP‐MS with laser ablation sampling (LA‐ICP‐MS) zircon analysis, but it is necessary to determine the correction factor for 206Pb/238U by measuring several zircon standards in individual laboratories.
Syntectonic Mobility of Supergene Nickel Ores of New Caledonia (Southwest Pacific). Evidence from Garnierite Veins and Faulted Regolith
Authors: Cluzel Dominique , Vigier Benoit 
Published: May 2008

AbstractSupergene nickel deposits of New Caledonia that have been formed in the Neogene by weathering of obducted ultramafic rocks are controlled by fracture development. The relationship of tropical weathering and tectonic structures, faults and tension gashes, have been investigated in order to determine whether fractures play a passive role only, as previously thought; or alternatively, if brittle tectonics was acting together with alteration. Observation of time‐relationship, textures, and mineralogy of various fracture fills and fault gouges shows that active faulting has played a prominent role not only in facilitating drainage and providing room for synkinematic crystallization of supergene nickel silicate, but also in mobilizing already formed sparse nickel ore, producing the very high grade ore nicknamed “green gold”.
The Safety and Efficacy of High‐Dose Alefacept Compared With a Loading Dose of Alefacept in Patients With Chronic Plaque Psoriasis
Authors: Cafardi Jennifer A. , Cantrell Wendy , Wang Wenquan , Elmets Craig A. , Elewski Boni E. 
Published: May 2008

Objectives
. Alefacept is a biologic response modifier indicated for moderate to severe psoriasis; it has been available since 2003. It is typically administered in a dosing regimen of 15 mg intramuscularly (IM) weekly for 12 weeks. The purpose of this study was to determine whether a higher dose may be more beneficial in achieving a 75% reduction in the Psoriasis Area and Severity Index (PASI 75). A secondary objective of this study was to examine whether increasing the dose during the initial course of alefacept would reduce the time to onset of efficacy and overall response rate. Two separate dosing regimens are evaluated in this study: 30 mg IM for 6 weeks followed by 15 mg IM for 6 weeks (group 1) and alefacept 30 mg IM weekly for 12 weeks (group 2).
Methods
. Efficacy was assessed using the PASI, Physician Global Assessment, body surface area, and photographic evaluation of a target lesion. A total of 20 patients enrolled and were randomized, 16 of whom completed the study. Data analyses were performed on a per‐protocol basis.
Results
. Overall, the mean PASI scores progressively decreased, with 43.8% reaching a 50% reduction in the PASI (PASI 50) at week 14 evaluation. Of these participants, 37.5% were in group 1 and 50% were treated with alefacept 30 mg IM for 12 weeks (group 2). Although our sample size was small, 12.5% of patients (one patient in each treatment arm) reached PASI 75. The most common adverse events encountered in this trial were mild infection, headache, pruritus, and erythroderma. There were no infections associated with a CD4+ cell count <250 cells/mm3.
Conclusions
. There was no difference between the treatment groups in achieving PASI 50 or PASI 75. In addition, in our small population, the higher doses of alefacept were associated with increased adverse effects, including erythroderma.
Molecular Survey of β-Lactamases Conferring Resistance to Newer β-Lactams in
Enterobacteriaceae
Isolates from Polish Hospitals
Authors: Empel Joanna , Baraniak Anna , Literacka Elżbieta , Mrówka Agnieszka , Fiett Janusz , Sadowy Ewa , Hryniewicz Waleria , Gniadkowski Marek 
Published: May 2008

ABSTRACT

The first national survey of resistance to newer β-lactams in nosocomial populations of
Enterobacteriaceae
in Poland was performed. The study covered all nonrepetitive enterobacterial isolates cultured from specimens from inpatients in 13 regional secondary-care hospitals from November 2003 to January 2004. Among 2,388 isolates, the predominant species was
Escherichia coli
(59.6%), followed by
Proteus mirabilis
(14.5%) and
Klebsiella
spp. (8.5%). The frequency of extended-spectrum β-lactamases (ESBLs) was very high, with ESBLs present in 11.1% of all isolates and 40.4% of
Klebsiella pneumoniae
isolates, the latter value greatly exceeding that for
E. coli
(2.5%). The contribution of outbreak isolates was significant, resulting, for example, in a particularly high rate of ESBL producers among
Serratia marcescens
isolates (70.8%). The pool of ESBL types was overwhelmingly dominated (81.7%) by CTX-M-like β-lactamases CTX-M-3 (80.6%) and CTX-M-15, with SHV types (17.5%; SHV-2, SHV-5, and SHV-12) and sporadic TEM-like enzymes (0.7%; TEM-19 and TEM-48) being the next most frequent. Acquired AmpC-type cephalosporinases were observed exclusively in
P. mirabilis
, in 20.5% of the isolates of this species (compared with the frequency of ESBL producers of 11.5% of
P. mirabilis
isolates). All these cephalosporinases (CMY-12, CMY-15, and a novel variant, CMY-38) originated from
Citrobacter freundii
. Four isolates of
E. coli
(two isolates),
K. pneumoniae
(one isolate), and
P. mirabilis
(one isolate) produced class A inhibitor-resistant β-lactamases (TEM-30, TEM-32, TEM-37, and SHV-49), being the first of such producers identified in Poland. The survey documented both specific and more global characteristics of the epidemiology of the β-lactamase-mediated resistance in enterobacteria from Polish hospitals and demonstrated that the ESBL frequency has reached an alarming level.
Chemical Target Validation Studies of Aminopeptidase in Malaria Parasites Using α-Aminoalkylphosphonate and Phosphonopeptide Inhibitors
Authors: Cunningham Eithne , Drag Marcin , Kafarski Pawel , Bell Angus 
Published: May 2008

ABSTRACT

During its intraerythrocytic phase, the most lethal human malarial parasite,
Plasmodium falciparum
, digests host cell hemoglobin as a source of some of the amino acids required for its own protein synthesis. A number of parasite endopeptidases (including plasmepsins and falcipains) process the globin into small peptides. These peptides appear to be further digested to free amino acids by aminopeptidases, enzymes that catalyze the sequential cleavage of N-terminal amino acids from peptides. Aminopeptidases are classified into different evolutionary families according to their sequence motifs and preferred substrates. The aminopeptidase inhibitor bestatin can disrupt parasite development, suggesting that this group of enzymes might be a chemotherapeutic target. Two bestatin-susceptible aminopeptidase activities, associated with gene products belonging to the M1 and M17 families, have been described in blood-stage
P. falciparum
parasites, but it is not known whether one or both are required for parasite development. To establish whether inhibition of the M17 aminopeptidase is sufficient to confer antimalarial activity, we evaluated 35 aminoalkylphosphonate and phosphonopeptide compounds designed to be specific inhibitors of M17 aminopeptidases. The compounds had a range of activities against cultured
P. falciparum
parasites with 50% inhibitory concentrations down to 14 μM. Some of the compounds were also potent inhibitors of parasite aminopeptidase activity, though it appeared that many were capable of inhibiting the M1 as well as the M17 enzyme. There was a strong correlation between the potencies of the compounds against whole parasites and against the enzyme, suggesting that M17 and/or M1 aminopeptidases may be valid antimalarial drug targets.
Exercise training alters effect of high-fat feeding on the ACTH stress response in pigs
Authors: Jankord Ryan , Ganjam Venkataseshu K. , Turk James R. , Hamilton Marc T. , Laughlin M. Harold 
Published: May 2008

Eating and physical activity behaviors influence neuroendocrine output. The purpose of this study was to test, in an animal model of diet-induced cardiovascular disease, the effects of high-fat feeding and exercise training on hypothalamo–pituitary–adrenocortical (HPA) axis activity. We hypothesized that a high-fat diet would increase circulating free fatty acids (FFAs) and decrease the adrenocorticotropic hormone (ACTH) and cortisol response to an acute stressor. We also hypothesized that exercise training would reverse the high-fat diet-induced changes in FFAs and thereby restore the ACTH and cortisol response. Pigs were placed in 1 of 4 groups (normal diet, sedentary; normal diet, exercise training; high-fat diet, sedentary; high-fat diet, exercise training; n = 8/group). Animals were placed on their respective dietary and activity treatments for 16–20 weeks. After completion of the treatments animals were anesthetized and underwent surgical intubation. Blood samples were collected after surgery and the ACTH and cortisol response to surgery was determined and the circulating concentrations of FFAs, glucose, cholesterol, insulin, and IGF-1 were measured. Consistent with our hypothesis, high-fat feeding increased FFAs by 200% and decreased the ACTH stress response by 40%. In exercise-trained animals, the high-fat diet also increased FFA; however, the increase in FFA in exercise-trained pigs was accompanied by a 60% increase in the ACTH response. The divergent effect of high-fat feeding on ACTH response was not expected, as exercise training alone had no effect on the ACTH response. Results demonstrate a significant interaction between diet and exercise and their effect on the ACTH response. The divergent effects of high-fat diet could not be explained by changes in weight gain, blood glucose, insulin, or IGF-1, as these were altered by high-fat feeding, but unaffected by exercise training. Thus, the increase in FFA with high-fat feeding may explain the blunted ACTH response to an acute stressor in sedentary animals, but cannot explain the exaggerated response in exercise trained animals.
Improved Forecasts of the Diurnal Cycle in the Tropics Using Multiple Global Models. Part I: Precipitation
Authors: Krishnamurti T. N. , Gnanaseelan C. , Mishra A. K. , Chakraborty A. 
Published: May 2008

Abstract
The Tropical Rainfall Measuring Mission (TRMM) satellite supplemented with the Defense Meteorological Satellites Program (DMSP) microwave dataset provides accurate rain-rate estimates. Furthermore, infrared radiances from the geostationary satellites provide the possibility for mapping the diurnal change of tropical rainfall. Modeling of the phase and amplitude of the tropical rainfall is the theme of this paper. The present study utilizes a suite of global multimodels that are identical in all respects except for their cumulus parameterization algorithms. Six different cumulus parameterizations are tested in this study. These include the Florida State University (FSU) Modified Kuo Scheme (KUO), Goddard Space Flight Center (GSFC) Relaxed Arakawa–Schubert Scheme (RAS1), Naval Research Laboratory–Navy Operational Global Atmospheric Prediction System (NRL–NOGAPS) Relaxed Arakawa–Schubert Scheme (RAS2), NCEP Simplified Arakawa–Schubert Scheme (SAS), NCAR Zhang–McFarlane Scheme (ZM), and NRL–NOGAPS Emanuel Scheme (ECS). The authors carried out nearly 600 experiments with these six versions of the T170 Florida State University global spectral model. These are 5-day NWP experiments where the diurnal change datasets were archived at 3-hourly intervals. This study includes the estimation of skills of the phase and amplitudes of the diurnal rain using these member models, their ensemble mean, a multimodel superensemble, and those from a single unified model. Test results are presented for the global tropics and for some specific regions where the member models show difficulty in predicting the diurnal change of rainfall. The main contribution is the considerable improvement of the modeling of diurnal rain by deploying a multimodel superensemble and by constructing a single unified model. The authors also present a comparison of these findings on the modeling of diurnal rain from another suite of multimodels that utilized different versions of cloud radiation algorithms (instead of different cumulus parameterization schemes) toward defining the suite of multimodels. The principal result is that the superensemble does provide a future forecast for the total daily rain and for the diurnal change of rain through day 5 that is superior to forecasts provided by the best model. The training of the superensemble with good observed estimates of rain, such as those from TRMM, is necessary for such forecasts.
Three-Dimensional Structure and Dynamics of African Easterly Waves. Part III: Genesis
Authors: Thorncroft Chris D. , Hall Nicholas M. J. , Kiladis George N. 
Published: May 2008

Abstract
This paper promotes the view that African easterly waves (AEWs) are triggered by localized forcing, most likely associated with latent heating upstream of the region of observed AEW growth. A primitive equation model is used to show that AEWs can be triggered by finite-amplitude transient and localized latent heating on a zonally varying basic state that is linearly stable. Heating close to the entrance region of the African easterly jet (AEJ) is shown to initiate AEWs downstream. The heating leads to an initial trough that reaches the West African coast about 5–7 days later, depending on the nature of the heating profile. After this, a structure that projects strongly onto the leading linear normal mode of the basic state becomes established, characterized by a number of westward-propagating disturbances that strongly resemble AEWs. The sensitivity of the forced AEWs to the nature and location of the heating profile is examined. AEWs are most efficiently triggered by heating profiles that establish lower tropospheric circulations close to the entrance region of the AEJ. In the present study, this was best achieved by lower tropospheric heating from shallow convection or upper-level heating and lower-level cooling from a stratiform precipitation profile. Both profiles have significant heating gradients in the vertical in the mid-to-lower troposphere. This triggering paradigm for the genesis of AEWs has consequences for the variability and predictability of AEWs at weather and climate time scales. In addition to the nature of the AEJ, often emphasized, it is crucial to consider the nature and variability of upstream heating triggers.
The Impact of Convection on ENSO: From a Delayed Oscillator to a Series of Events
Authors: Neale Richard B. , Richter Jadwiga H. , Jochum Markus 
Published: May 2008

Abstract
The NCAR Community Climate System Model, version 3 (CCSM3) exhibits persistent errors in its simulation of the El Niño–Southern Oscillation (ENSO) mode of coupled variability. The amplitude of the oscillation is too strong, the dominant 2-yr period too regular, and the width of the sea surface temperature response in the Pacific too narrow, with positive anomalies extending too far into the western Pacific. Two changes in the parameterization of deep convection result in a significant improvement to many aspects of the ENSO simulation. The inclusion of convective momentum transport (CMT) and a dilution approximation for the calculation of convective available potential energy (CAPE) are used in development integrations, and a striking improvement in ENSO characteristics is seen. An increase in the periodicity of ENSO is achieved by a reduction in the strength of the existing “short-circuited” delayed-oscillator mode. The off-equatorial response is weaker and less tropically confined, largely as a result of the CMT and an associated redistribution of zonal momentum. The Pacific east–west structure is improved in response to the presence of convective dilution and cooling provided by increased surface fluxes. The initiation of El Niño events is fundamentally different. Enhanced intraseasonal surface stress variability leads to absolute surface westerlies and a cooling–warming dipole between the Philippine Sea and western Pacific. Lag-regression analysis shows that intraseasonal variability may play a significant role in event initiation and maintenance as opposed to being a benign response to increased SSTs. Recent observational evidence appears to support such a leading relationship.
A Nonlinear Artificial Intelligence Ensemble Prediction Model for Typhoon Intensity
Authors: Jin Long , Yao Cai , Huang Xiao-Yan 
Published: May 2008

AbstractA new nonlinear artificial intelligence ensemble prediction (NAIEP) model has been developed for predicting typhoon intensity based on multiple neural networks with the same expected output and using an evolutionary genetic algorithm (GA). The model is validated with short-range forecasts of typhoon intensity in the South China Sea (SCS); results show that the NAIEP model is clearly better than the climatology and persistence (CLIPER) model for 24-h forecasts of typhoon intensity. Using identical predictors and sample cases, predictions of the genetic neural network (GNN) ensemble prediction (GNNEP) model are compared with the single-GNN prediction model, and it has been proven theoretically that the former is more accurate. Computation and analysis of the generalization capacity of GNNEP also demonstrate that the prediction of the ensemble model integrates predictions of its optimized ensemble members, so the generalization capacity of the ensemble prediction model is also enhanced. This model better addresses the “overfitting” problem that generally exists in the traditional neural network approach to practical weather prediction.
Randomized Phase III Trial Comparing Retroperitoneal Lymph Node Dissection With One Course of Bleomycin and Etoposide Plus Cisplatin Chemotherapy in the Adjuvant Treatment of Clinical Stage I Nonseminomatous Testicular Germ Cell Tumors: AUO Trial AH 01/94 by the German Testicular Cancer Study Group
Authors: Albers Peter , Siener Roswitha , Krege Susanne , Schmelz Hans-Uwe , Dieckmann Klaus-Peter , Heidenreich Axel , Kwasny Peter , Pechoel Maik , Lehmann Jan , Kliesch Sabine , Köhrmann Kai-Uwe , Fimmers Rolf , Weiβbach Lothar , Loy Volker , Wittekind Christian , Hartmann Michael 
Published: May 2008

Purpose Retroperitoneal lymph node dissection (RPLND) and adjuvant chemotherapy are two adjuvant treatment options for patients with clinical stage I nonseminomatous germ cell tumors of the testis (NSGCT). Aim of this trial was to prove the advantage of one cycle of bleomycin, etoposide, and cisplatin (BEP) chemotherapy compared with RPLND in terms of recurrence. Patients and Methods Between 1996 and 2005, 382 patients were randomly assigned to receive either RPLND (n = 191) or one course of BEP (n = 191) after orchidectomy. The primary study end point was the rate of recurrence. The trial was powered to detect a 7% reduction (from 10% to 3%) of recurrence with chemotherapy compared with surgery. Results After a median follow-up of 4.7 years, two and 15 recurrences were observed in the intention-to-treat population with chemotherapy and surgery, respectively (P = .0011). The difference in the 2-year recurrence-free survival rate between chemotherapy (99.46%; 95% CI, 96.20% to 99.92%) and surgery (91.87%; 95% CI, 86.87% to 95.02%) was 7.59% (95% CI, 3.13% to 12.05%). The hazard ratio to experience a tumor recurrence with surgery as opposed to chemotherapy was 7.937 (95% CI, 1.808 to 34.48). Conclusion To our knowledge, this is the largest randomized trial investigating adjuvant treatment strategies in clinical stage I NSGCT, which showed the superiority of one course BEP over RPLND performed according to community standards to prevent recurrence. Although not standard treatment, one course of BEP is active in an unselected group of patients with clinical stage I disease and merits further investigation.
The State and Coordinated Capitalism: Contributions of the Public Sector to Social Solidarity in Postindustrial Societies
Authors: Martin Cathie Jo , Thelen Kathleen 
Published: May 2008

This article investigates the politics of change in coordinated market econo\mies, and explores why some countries (well known for their highly cooperative arrangements) manage to sustain coordination when adjusting to economic transformation, while others fail. The authors argue that the broad category of “coordinated market economies” subsumes different types of cooperative engagement:macrocorporatutforms of coordination are characterized by national-level institutions for fostering cooperation and feature a strong role for the state, while forms of coordination associated withenterprise cooperationmore typically occur at the level of sector or regional institutions and are often privately controlled. Although these diverse forms of coordination once appeared quite similar and functioned as structural equivalents, they now have radically different capacities for self-adjustment.The role of the state is at the heart of the divergence among European coordinated countries. A large public sector affects the political dynamics behind collective outcomes, through its impact both on the state's construction of its own policy interests and on private actors' goals. Although a large public sector has typically been written off as an inevitable drag on the economy, it can provide state actors with a crucial political tool for shoring up coordination in a postindustrial economy. The authors use the cases of Denmark and Germany to illustrate how uncontroversially coordinated market economies have evolved along two sharply divergent paths in the past two decades and to reflect on broader questions of stability and change in coordinated market economies. The two countries diverge most acutely with respect to the balance of power between state and society; indeed, the Danish state—far from being a constraint on adjustment (a central truism in neoliberal thought)—plays the role of facilitator in economic adjustment, policy change, and continued coordination.