bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer survival in Germany and the United States at the beginning of the 21st century: An up‐to‐date comparison by period analysis
Authors: Gondos Adam , Arndt Volker , Holleczek Bernd , Stegmaier Christa , Ziegler Hartwig , Brenner Hermann 
Published: March 2007

AbstractTransatlantic cancer survival comparisons are scarce and involve mostly aggregate European data from the late 1980s. We compare the levels of cancer patient survival achieved in Germany and the United States (US) by the beginning of the 21st century, using data from the Cancer Registry of Saarland/Germany and the SEER Program of the US. Age‐adjusted 5‐ and 10‐year relative survival for 23 common forms of cancer derived by period analysis for the 2000–2002 period were calculated, with additional detailed age‐ and stage‐specific analyses for cancers with the highest incidence. Among the 23 cancer sites, 5 (10) year relative survival was significantly higher for 1 (2) and 8 (5) cancers in Germany and the US, respectively. In Germany, survival was significantly higher for patients with stomach cancer, whereas survival was higher in the US for patients with breast, cervical, prostate, colorectal and oral cavity cancer. Among the most common cancers, age‐specific survival differences were particularly pronounced for older patients with breast, colorectal and prostate cancer. Survival advantages of breast cancer patients in the US were mainly due to more favorable stage distributions. This comprehensive survival comparison between Germany and the US suggests that although survival was similar for the majority of the compared cancer sites, long‐term prognosis of patients continues to be better in the US for many of the most common forms of cancer. Among these, differences between patients with breast and prostate cancer are probably due to more intensive screening activities. © 2007 Wiley‐Liss, Inc.
Gains and complex rearrangements of the 12q13‐15 chromosomal region in ordinary lipomas: The “missing link” between lipomas and liposarcomas?
Authors: Italiano Antoine , Cardot Nathalie , Dupré Florence , Monticelli Isabelle , Keslair Frédérique , Piche Marjorie , Mainguené Claire , Coindre Jean‐Michel , Pedeutour Florence 
Published: March 2007

AbstractWell‐differentiated liposarcomas (WDLPS) classically contain high‐level amplification of 12q14‐15 sequences, including the MDM2 and CDK4 genes, while lipomas are characterized by simple structural chromosome aberrations often involving HMGA2 at 12q15. Previous studies have shown that low‐level gain of the 12q14‐15 region, such as trisomy 12 and 12q15‐24 duplication, might be sufficient for the development of minimal atypia and formation of WDLPS. Moreover, because some features, such as overexpression of HMGA2, are shared by both lipomas and WDLPS, it has been hypothesized that lipomas and WDLPS may form a genetic and morphological continuum. We report here the results of molecular cytogenetic analysis of 8 lipomas that had unusual chromosomal features resulting in gains of 12q14‐15. While 3 cases had simple numerical rearrangements (trisomy 12) or structural rearrangements (unbalanced translocations with 12q gains), 5 cases were particularly intriguing because of peculiar features such as giant chromosomes, supernumerary chromosomes or neocentromeres that usually are the hallmark of WDLPS. Gain of 12q14‐15 sequences including extra copies of MDM2 and CDK4 were detected by fluorescence in situ hybridization analysis in all analyzed cases but no expression of MDM2 and CDK4 was observed suggesting that these genomic imbalances had no functional consequence. We observed rearrangements of HMGA2 in 5 out 8 cases. Altogether, our results indicate that moderate gains of 12q are not always associated with a malignant phenotype, and that some intermediary forms exist between classical lipomas and classical WDLPS. Some of these intermediary forms may correspond to a genomic premalignant condition while some may have no malignant potential. © 2007 Wiley‐Liss, Inc.
Role of S128R polymorphism of E‐selectin in colon metastasis formation
Authors: Alessandro Riccardo , Seidita Gregorio , Flugy Anna Maria , Damiani Francesca , Russo Antonio , Corrado Chiara , Colomba Paolo , Gullotti Lucia , Buettner Reinhard , Bruno Loredana , Leo Giacomo De 
Published: March 2007

AbstractThe extravasation of cancer cells is a key step of the metastatic cascade. Polymorphisms in genes encoding adhesion molecules can facilitate metastasis by increasing the strength of interaction between tumor and endothelial cells as well as impacting other properties of cancer cells. We investigated the Ser128Arg (a561c at the nucleotide level) polymorphism in the E‐selectin gene in patients with metastatic colon cancer and its functional significance. Genotyping for a561c polymorphism was performed on 172 cancer patients and on an age‐matched control population. The colon cancer group was divided into groups with (M+) and without observable metastasis (M−). For in vitro functional assays, Huvec transfected cells expressing wild‐type (WT) or the S128R variant of E‐selectin were established to study in vitro binding ability and signal transduction processes of T84 colon cancer cell line. Our results demonstrated that the Arginine128 allele was more prevalent in the M+ group than in the M− group or normal controls (p < 0.005; odds ratio, 1.56; 95% confidence interval (CI) 1.16–1.92; p < 0.001, odds ratio = 1.65; CI = 1.24–1.99, respectively). In vitro, S128R E‐selectin transfected Huvec cells, supported increased adhesion as well as increased cellular signaling of T84 cancer cells compared to WT E‐selectin and mock‐transfected Huvec cells. These findings suggest that the E‐selectin S128R polymorphism can functionally affect tumor‐endothelial interactions as well as motility and signaling properties of neoplastic cells that may modulate the metastatic phenotype. © 2007 Wiley‐Liss, Inc.
Selecting the right costing tool for your business needs
Authors: Gurowka Jim , Lawson Raef A. 
Published: March 2007

AbstractManagement accountants designing an organization's performance management system face a dizzying array of costing approaches and techniques. This article describes the current “clutter in costing,” then provides a road map to help finance and accounting professionals decide which tools to use when, and how to recognize when it is time to change costing systems. © 2007 Wiley Periodicals, Inc.
SOX 404 and ERM: Perfect partners … or not?
Authors: Thomson Jeffrey C. 
Published: March 2007

AbstractThe Sarbanes‐Oxley Act (SOX) Section 404 regulations and guidance have had a large impact on the adoption of enterprise risk management (ERM) in the United States. In the short run, SOX 404 has impeded the adoption of risk‐based approaches because of its rules that are totally counter to a holistic, risk‐based approach. In the longer run, SOX provides an opportunity for even faster adoption of ERM—but only if there is more radical thinking on the part of regulators and practitioners alike in training, education, and certification of this body of knowledge. © 2007 Wiley Periodicals, Inc.
Analysts' forecasts: Why are they biased?
Authors: Becchetti Leonardo , Hasan Iftekhar , Santoro Marika , Anandarajan Asokan 
Published: March 2007

AbstractThe stock market is driven by analysts' forecasts. Investors rely on them. But research has shown that analysts' forecasts are biased. What causes this? And what kinds of stocks are most affected? © 2007 Wiley Periodicals, Inc.
C‐terminal pentapeptide of osteogenic growth peptide regulates hematopoiesis in early stage
Authors: Hui Zhong , Yu Liu , Xiaoli Yang , Xiang He , Fan Zhao , Ningbo Hou , Zhigang Yuan , Ping Li , Yanhong Zhang , Qingjun Ma 
Published: March 2007

AbstractOsteogenic growth peptide (OGP) was characterized in regenerating bone marrow, which can increase osteogenesis and hematopoiesis. The carboxy‐terminal pentapeptide is a naturally occurring human and murine mitogen equipotent to OGP. In this study, we evaluated the potential role of OGP10–14 in regulation of hematopoiesis in human hematopoietic stem cells and animal model. Our results showed CD34+ stem cells from umbilical cord blood (UBC) were significantly increased in OGP10–14 treated samples, which is nearly equivalent to the results obtained from the combinations of IL3, IL11, G‐CSF, and EPO group. OGP10–14 can also stimulate the differentiation of stem cells from bone marrow at the level of noncommitted progenitor stem cells, thus increasing the number of reconstituted red and white cells as well as platelets after injected i.m. everyday continuing for 5 days in hematopoietic function damage mice comparing with the OGP‐untreated group. These data implicate that the role of OGP10–14 regulating hematopoiesis is in the early stage of the whole hematopoietic growth factors (HGFs) regulating network, just like the position of interleukin 13 in the hematopoiesis network. J. Cell. Biochem. 101: 1423–1429, 2007. © 2007 Wiley‐Liss, Inc.
Insulin‐like growth factor (IGF)‐II regulates CCAAT/enhancer binding protein α expression via phosphatidyl‐inositol 3 kinase in human hepatoblastoma cell lines
Authors: Tomizawa Minoru , Saisho Hiromitsu 
Published: March 2007

AbstractTo reveal growth factor and its signal pathway to CCAAT/enhancer binding protein alpha (C/EBPα) in hepatocyte differentiation, we used Huh‐6 and HepG2, human hepatoblastoma (HBL) cell lines that maintain the expression of genes in hepatoblasts and remain at that stage of differentiation. Insulin‐like growth factor (IGF)‐II, hepatocyte growth factor (HGF), and dexamethasone (Dex) stimulated HBL cells for Northern blot analysis. Bromodeoxyuridine (BrdU) up‐take assay and Western blot analysis on albumin was performed to unveil proliferation and differentiation activity of IGF‐II. C/EBPα and phosphorylation of Akt were analyzed by Western blot analysis. LY294002 and wortmannin, specific inhibitors of PI3 kinase, and PD98059, a specific inhibitor of mitogen‐activated protein (MAP) kinase, were used to examine the signaling pathway of C/EBPα upregulated by IGF‐II. Luciferase assay was performed to study the promoter activity of C/EBPα. Actinomycin D was used to analyze half‐life of C/EBPα mRNA. IGF‐II up‐regualted C/EBPα by Northern blot and Western blot while HGF and Dex did not by Northern blot. IGF‐II promoted proliferation and differentiation by BrdU up‐take assay and Western blot analysis on albumin. Akt phosphorylated by IGF‐II, suggested that phosphatidyl‐inositol (PI) 3 kinase mediated the signaling pathway of IGF‐II. LY294002 and wortmannin suppressed expression of C/EBPα. IGF‐II activated the promoter activity and prolonged half‐life of mRNA, suggesting that IGF‐II activated promoter and stabilized mRNA. LY294002 and wortmannin suppressed the promoter activity of C/EBPα while PD98059 did not, suggesting that activation of the promoter was mediated by PI3 kinase. J. Cell. Biochem. 102: 161–170, 2007. © 2007 Wiley‐Liss, Inc.
Evaluation of bone‐derived and marrow‐derived vascular endothelial cells by microarray analysis
Authors: Sosnoski Donna M. , Gay Carol V. 
Published: March 2007

AbstractThis study focused on the differential expression levels of proteins that may exist between bone‐derived and marrow‐derived vascular endothelial cells (BVEC and MVEC). The vascular cells were isolated from trabecular bone regions and central marrow cavity regions of mouse long bones. Cells were cultured for 1 week to expand the population then separated from non‐vascular cells using biotinylated isolectin B4, streptavidin‐coated metallic microbeads, and a magnetic column. After an additional week of culture time, RNA was isolated from both cell types and compared using microarray analysis. RT‐PCR was used to confirm and relatively quantitate the RNA messages. The bone‐derived cells expressed more aldehyde dehydrogenase 3A1 (ALDH3A1), Secreted Modular Calcium‐2 (SMOC‐2), CCAAT enhancer binding protein (C/EBP‐β), matrix metalloproteinase 13 (MMP‐13), and annexin 8 (ANX8) than the marrow‐derived cells. Spα and matrix GLA‐protein (MGP) were produced in greater abundance by the marrow‐derived cells. This study reveals that there are profound and unique differences between the vasculature of the metaphysis as compared to that of the central marrow cavity. The unique array of proteins expressed by the bone‐derived endothelial cells may support growth of tumors from cancer cells that frequently metastasize and lodge in the trabecular bone regions. J. Cell. Biochem. 102: 463–472, 2007. © 2007 Wiley‐Liss, Inc.
Comparative morphology of the hemolymph vascular system in scorpions–A survey using corrosion casting, MicroCT, and 3D‐reconstruction
Authors: Wirkner Christian S. , Prendini Lorenzo 
Published: March 2007

AbstractAlthough scorpions are one of the better known groups of Arthropoda, detailed knowledge of their anatomy remains superficial. This contribution presents the first comprehensive investigation of the gross morphology of the scorpion vascular system, based on a survey of species representing all major lineages of the order, using classical and modern non‐destructive techniques in combination with three‐dimensional reconstruction. The investigation reveals that the hemolymph vascular system (HVS) of Scorpiones comprises a central pumping heart which extends the entire length of the mesosoma and is enclosed in a pericardium. Several arteries branch off the heart to supply different organs and body regions. Two different anterior aorta major branching patterns are identified among the species investigated. Arteries that branch off the anterior aorta system supply the appendages (chelicerae, pedipalps, and walking legs) and the central nerve mass with a complex arterial network. This study of the HVS of scorpions provides further evidence that the vascular systems of euarthropods can be highly complex. Use of the term “open circulatory system” within arthropods is re‐emphasized, as it refers to the general organization of the body cavity (i.e. mixocoely) rather than to the complexity of the circulatory system. J. Morphol., 2007. © 2007 Wiley‐Liss, Inc.
Spectroscopic study of phase transitions in dolomite mineral
Authors: Gunasekaran S. , Anbalagan G. 
Published: March 2007

AbstractThe process and the formation of new minerals upon heating carbonate rocks containing clay minerals together with dolomite are determined by thermal analysis, X‐ray diffraction (XRD), infrared and Raman spectroscopy. The dolomite–calcite–calcium oxide phase transition sequences were followed up to 947 °C in a naturally occurring dolomite sample. The spectral variations of the internal modes of the carbonate trigonal (ν1, ν2, ν3 and ν4) were used to probe the structural phase transitions. A new Raman mode emerged at 1090 cm−1 in the ν1 mode region, and infrared modes emerged at 713, 874, and 1420 cm−1 in the ν4, ν2 and ν3 regions at 750 °C, indicating the onset of the dolomite phase. The calcium oxide phase, (which on reaction with atmospheric water forms portlandite) with an onset temperature of around 950 °C, was also characterized by the appearance of the infrared mode around 450 cm−1. The minerals, which were formed upon heating the dolomite, were calcite, calcium oxide and diopside. Copyright © 2007 John Wiley & Sons, Ltd.
The influence of pH and anions on the adsorption mechanism of rifampicin on silver colloids
Authors: Howes Barry D. , Guerrini Luca , Sanchez‐Cortes Santiago , Marzocchi Mario P. , Garcia‐Ramos José V. , Smulevich Giulietta 
Published: March 2007

AbstractThe influence of pH and anions on the adsorption mechanism of rifampicin on colloidal silver nanoparticles has been analysed by electronic absorption, resonance Raman (RR) and surface‐enhanced resonance Raman spectroscopy (SERRS). Rifampicin is a widely used antibiotic with a zwitterionic nature. SERRS spectra of rifampicin adsorbed on silver sols, prepared using hydroxylamine hydrochloride as reducing agent, undergo dramatic changes upon lowering the pH. The spectral form changes progressively from that characteristic of chemisorbed rifampicin (at pH > 7) to one very similar to the rifampicin RR spectrum (at lower pH), indicative of a modification of the adsorption mechanism on the surface of the Ag nanoparticles. The RR‐type SERRS spectrum is proposed to result from formation of an ion pair between rifampicin and Cl− anions, which, deriving from the colloid preparation, are adsorbed on the Ag surface. The addition of anions to the hydroxylamine hydrochloride sol facilitates conversion from the chemisorbed to ion pair form and leads to an order of magnitude increase in the SERRS signal. Copyright © 2007 John Wiley & Sons, Ltd.
Multianalyte immunoassay based on surface‐enhanced Raman spectroscopy
Authors: Cui Yan , Ren Bin , Yao Jian‐Lin , Gu Ren‐Ao , Tian Zhong‐Qun 
Published: March 2007

AbstractIn this paper, two immunoassay methods based on SERS are developed for multiplex analysis, both of which stemmed from the concept of forming a sandwich structure ‘capture antibody substrate/antigen/Raman‐reporter‐labeled immuno‐nanoparticles’. They are two‐molecule labeled one‐nanoparticle and one‐molecule labeled two‐nanoparticle methods. In both the methods, two different antibodies covalently bound to a solid substrate can specifically capture two different antigens from a sample. The captured antigens in turn bind selectively to their corresponding antibodies immobilized on Raman‐reporter‐labeled nanoparticles. Multianalyte immunoassay is successfully demonstrated by the detection of characteristic Raman bands of the probe molecules only when the antigen and antibody are matched. Copyright © 2007 John Wiley & Sons, Ltd.
A novel technique of management of high output chyle leak after neck dissection
Authors: Qureshi Sajid S. , Chaturvedi Pankaj 
Published: March 2007

AbstractThe occurrence of postoperative chyle leak after neck dissection or vascular surgery of the subclavian and vertebral artery is a well‐known but rare complication. The management of chyle leak ranges from utilizing a myriad of conservative procedures to surgical exploration. Occasionally on surgical exploration the chyle leak is diffuse and ligation of the bed of thoracic duct is not adroit to stopping the chyle leak. We describe a technique, which will be useful in this circumstance and in recurrent chyle leak after a previous exploration. J. Surg. Oncol. 2007;96:176–177. © 2007 Wiley‐Liss, Inc.
Policy issues related to the rehabilitation of the surgical cancer patient
Authors: Hewitt Maria , Maxwell Stephanie , Vargo Mary M. 
Published: March 2007

AbstractFour policy challenges that face the rehabilitation community in providing services to surgical cancer patients are reviewed: (1) achieving capacity to meet the complex rehabilitation needs of a growing population of cancer patients and long‐term survivors; (2) identifying effective models for delivering cancer rehabilitation services; (3) understanding complex insurance coverage and payment policies and determining their effects on access to rehabilitation services; and (4) investing in clinical and health services research to guide rehabilitation practice. Recommendations are made to increase the recognition of cancer rehabilitation as an essential component of cancer survivors' care, improve access to appropriate rehabilitation services, and accelerate the pace of cancer rehabilitation research. J. Surg. Oncol. 95:370–385. © 2007 Wiley‐Liss, Inc.
Temperature dependencies of amide 1H‐ and 15N‐chemical shifts in hyaluronan oligosaccharides
Authors: Blundell Charles D. , Almond Andrew 
Published: March 2007

AbstractTemperature coefficients (Δδ/ΔT) of amide chemical shifts of N‐acetylglucosamine residues have been measured in a range of oligosaccharides of the important vertebrate polysaccharide hyaluronan. Odd‐ and even‐numbered oligosaccharides with glucuronic acid, Δ‐4,5‐unsaturated glucuronic acid and N‐acetylglucosamine at the termini were investigated. All amide proton temperature coefficients were only slightly less negative (−6.9 to − 9.1 ppb/ °C) than those of amide protons in free exchange with water (≈− 11 ppb/ °C), indicating an absence of persistent intramolecular hydrogen bonds. With the exception of amide groups in reducing‐terminal N‐acetylglucosamine rings, all amide proton environments have the same temperature coefficient (−6.9 ppb/ °C), irrespective of differences in amide group chemical shifts and 3JHH coupling constants, i.e. they do not sense subtle differences in orientation of the amide group. Amide nitrogen temperature coefficients report the same phenomena but with greater sensitivity. These data provide a set of reference values for temperature coefficients measured in other carbohydrates with acetamido sugars. Copyright © 2007 John Wiley & Sons, Ltd.
1H and 13C NMR assignments for two anthraquinones and two xanthones from the mangrove fungus (ZSUH‐36)
Authors: Shao Changlun , She Zhigang , Guo Zhiyong , Peng Hong , Cai Xiaoling , Zhou Shining , Gu Yucheng , Lin Yongcheng 
Published: March 2007

AbstractWe report the unambiguous assignments of the 1H and 13C NMR spectra of one new natural product, namely, 6,8‐di‐O‐methyl versiconol (1) together with one known anthraquinone aversin (2) and two xanthones 5‐methoxysterigmatocystin (3) and sterigmatocystin (4). These compounds were all isolated from the mangrove endophytic fungus ZSUH‐36 from the South China Sea. 1D and 2D NMR experiments including COSY, HMQC and HMBC were used to elucidate the structures. Variations in the 1H NMR spectrum of 6,8‐di‐O‐methyl versiconol (1) were also observed in the temperature range 25–75 °C. In addition, the plausible biogenetic path from 1 to 2 is discussed. Copyright © 2007 John Wiley & Sons, Ltd.
1H and 13C NMR assignments for two oxaphenalenones bacillosporin C and D from the mangrove endophytic fungus SBE‐14
Authors: Guo Zhiyong , Shao Changlun , She Zhigang , Cai Xiaoling , Liu Fan , Vrijimoed L. L. P. , Lin Yongcheng 
Published: March 2007

AbstractThe complete 1H and 13C NMR assignments are reported for the novel natural product Bacillosporin D together with the known compound Bacillosporin C. These compounds containing seven rings were isolated from the mangrove endophytic fungus SBE‐14 from the South China Sea. 1D and 2D NMR experiments, including COSY, HMQC and HMBC were used to the determination of the structures and NMR assignments. It is proposed that 1 was biogenetically produced by transforming 2. Transforming a lactone to an anhydride is unusual in nature. Copyright © 2007 John Wiley & Sons, Ltd.
Nonprofit agency dependence on direct service and indirect support volunteers: An empirical investigation
Authors: Hartenian Linda S. 
Published: March 2007

AbstractThirty agency directors or volunteer coordinators were interviewed regarding the human resource techniques they use to attract and retain two types of volunteers: direct service and indirect support. Agencies that depend on direct (point‐of‐service) volunteers are more likely to bring volunteers on board and use the performance feedback process to guide any needed improvements. Role playing and mentoring are particularly effective training techniques for these volunteers. Despite the critical function of point‐of‐service volunteers, more sophisticated recruitment and screening techniques were not used, contrary to expectations. Agencies that depend on indirect support volunteers use the recruitment process to screen out those who would not be successful volunteers and terminate them quickly for lack of confidentiality and reliability, particularly if they have had on‐the‐job training. Agencies hesitate to terminate direct service volunteers even for lack of ability and violations of policies and procedures. Finally, agencies used nonmonetary rewards with indirect support, but not direct service, volunteers. Implications of these findings and others are discussed.