bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aspergillosis of the nose and paranasal sinuses in neutropenic patients at an oncology center
Authors: Landoy Zvi , Rotstein Coleman , Shedd Donald 
Published: February 2007

AbstractInvasive aspergillosis of the nose and paranasal sinuses is one of the presentations of aspergillosis in granulocytopenic patients with neoplastic disorders. It is most prevalent among patients with leukemia and granulocytopenia and is associated with a high mortality rate. We report five cases of invasive aspergillosis of the nose and paranasal sinuses in profoundly neutropenic patients treated with broad spectrum antibiotics. Both Aspergillus fumigatus and Aspergillus flavus were cultured and identified in this entity. Awareness of this disease and early diagnosis made by culture and histologic examinations of biopsy material are essential. Treatment consisting of amphotericin B therapy and surgical debridement can be effective in eradicating this form of aspergillosis.
A compendium of intraoral flaps
Authors: Komisar Arnold , Lawson William 
Published: February 2007

AbstractIntraoral flaps are an excellent source of tissue for reconstruction after resection of small malignant tumors of the oral cavity, pharynx, and hypopharynx. The principal donor sites used are the tongue, buccal mucosa, and palate. Intraoral flaps enable rapid rehabilitation of deglutition and speech with minimal morbidity. They provide easily transferred, well‐vascularized tissue from sites adjacent to the operative defects. These flaps permit closure without tension and obviate the need for more distant tissue transfers. Their use does not compromise the oncologic resection.
Clear cell odontogenic tumor— a new histologic variant with aggressive potential
Authors: Hansen Louis S. , Eversole L. Roy , Green T. L. , Powell Nelson B. 
Published: February 2007

AbstractThis report delineates the clinical and laboratory findings for a previously unreported neoplasm of putative odontogenic origin. We describe the clinical, radiographic, operative, histologic, histochemical, and ultrastructural findings of the tumor in three women. All lesions were centrally located in the jaw bones, were expansile, and, except for mobile teeth and/or jaw enlargement, exhibited few symptoms. Radiographically, there was bone and tooth destruction resulting in poorly delineated margins. Microscopically, the tumors were nearly identical in that they consisted primarily of large sheets and islands of uniform vacuolated and clear cells without evidence of amyloid deposition, calcification, or glandular differentiation. One of the lesions recurred 1 1/2 years after removal without evidence of metastasis. The results, based only on these cases, suggest that this is a locally aggressive neoplasm of odontogenic origin. Casual microscopic examination of this rare neoplasm could result in misdiagnosis as a metastatic clear cell neoplasm, especially renal cell carcinoma.
Congenital benign mesenchymoma of the head and neck
Authors: Doraiswamy Nanjappachetty Velaswamychetty , Naqeeb Nai'L Al , Ali Syed Mukarram 
Published: February 2007

AbstractCongenital benign mesenchymoma of the head and neck is rare. One such case, presenting as a mass in the neck, is reported and the literature reviewed. Pathologic nature of the lesion is discussed. Prognosis after adequate local excision is good.
Preoperative simultaneously administered cis‐platinum plus radiation therapy for advanced squamous cell carcinoma of the head and neck
Authors: Slotman Gus J. , Cummings Frank J. , Glicksman Arvin R. , Doolittle Charles L. , Leone Louis A. 
Published: February 2007

AbstractSynchronously administered cis‐platinum (cis‐DDP) and radiation therapy have been used to treat unresectable squamous cell carcinomas of the head and neck. The purpose of this study was to evaluate the efficacy and tolerance of preoperative adjuvant cis‐DDP plus radiation therapy in operable stage III and IV head and neck cancers. Radiation therapy (4,500 rad) was delivered in 180‐rad daily fractions. Cis‐DDP (20 mg/M2) was given before radiotherapy on days 1–4 and 21–24. Eighteen patients began therapy; 16 completed the combined regimen. Toxicity included stomatitis (3) and WBC below 2,500/mm3 (2). One patient died from therapy of a cerebrovascular accident. Sixteen patients (89%) achieved a complete or partial response to therapy. Complete responses were observed in 13 of 18 primary tumors (72%), and in all three patients with cervical lymphadenopathy. Complete responses were noted for lesions of the nasopharynx, oral cavity, pharynx, hyopharynx, and larynx, for all histologic grades of squamous cell carcinoma. Twelve patients underwent curative surgery. Site‐related morbidity occurred in two patients (15%) and a third patient developed postoperative pneumonia. Five of 10 resected primary tumors with preoperative complete responses were pathologically negative for tumor. Concurrent bolus cis‐DDP and radiation therapy are welltolerated and result in impressive tumor reduction. Morbidity after subsequent curative surgery is low, and histologic complete responses are frequent. Trials of this promising combined modality approach to advance operable cancers of the head and neck, when compared to other treatment sequences, appear warranted.
Salivary neoplasms: Overview of a 35‐year experience with 2,807 patients
Authors: Spiro Ronald H. 
Published: February 2007

AbstractWe have reviewed a 35‐year experience with 2,807 patients treated for salivary tumors which arose in the parotid gland (1,695 patients; 70%), submandibular gland (235 patients; 8%), and seromucinous glands of the upper aerodigestive tract (607 patients; 22%). Pleomorphic adenomas comprised 45% of the total, most of which occurred in the parotid gland. The clinical findings and the distribution of patients according to the histology and the site of origin are summarized. Treatment was surgical and the resection was conservative when possible, depending upon the extent of the tumor. The impact of site, histology, grade, and tumor stage on the results is shown.
Modified pectoralis major myocutaneous flap with partial preservation of the muscle: A study of 55 cases
Authors: de Azevedo Jorge Ferreira 
Published: February 2007

AbstractThe results of a technical modification of the pectoralis major myocutaneous flap are presented in which the clavicular bundles, the first two or three sternocostal bundles, and the lateral border of the muscle were preserved. The flap was delivered into the neck through a subclavicular tunnel. The procedure was performed in 55 patients, with a bilateral simultaneous flap used in one. Four instances of flap necrosis occurred, although it was felt that they were not related to the modified technique, and no damage to the subclavian vessel occurred. In the first 25 flaps, we did not identify the neurovascular bundle supplying the preserved musculature. Eighteen of these flaps were evaluated, and atrophy was encountered in 10. Of the latter 31 patients, only one suffered atrophy of the sternocostal bundle. The technical modification of preserving part of the muscle and its neurovascular supply is especially important in manual workers. Twentyeight of 38 patients with preserved muscle function at the donor site were manual workers, and 10 of them returned to normal activity. None of the patients who developed atrophy of the pectoralis major muscular remnant was able to return to work within 1 year or longer after treatment. In the successful cases, there were no functional sequelae of the arm, visible depressions in the infraclavicular area, or loss of the anatomic configuration of the anterior axillary line.
Salvage surgery for recurrent neck carcinoma after multimodality therapy
Authors: Urken Mark , Biller Hugh F. , Lawson William , Haimov Moshe 
Published: February 2007

AbstractRecurrent carcinoma of the neck after treatment by radical neck dissection and radiotherapy leads to a progressive downhill course if no further therapy is instituted. Nine such patients having fixed, recurrent neck tumors with carotid artery involvement underwent 10 salvage procedures with carotid artery resection and replacement. One patient developed a transient hemiparesis that resolved in 3 days, and in another, a permanent hemiparesis occurred. Three patients have survived longer than 12 months. One patient is free of disease at 42 months following two salvage operations. We attribute the low operative morbidity to the frequent use of the subclavian artery for proximal anastomosis and myocutaneous flaps to resurface cutaneous and mucosal defects. We conclude that salvage surgery with carotid artery replacement can be performed on selected patients who have failed combined therapy as a palliative and possibly curative measure.
Small cell carcinoma of the head and neck
Authors: Baugh Reginald F. , Wolf Gregory T. , McClatchey Kenneth D. 
Published: February 2007

AbstractTreatment methods for patients with small cell carcinoma of the head and neck are changing. Increasing clinical experience with these tumors and a better appreciation of patterns of recurrence, the need for thorough tumor staging, and the importance of chemotherapy as a form of primary therapy have contributed to these changes. Current concepts regarding small cell carcinoma arising in the head and neck are reviewed. Reported results of treatment for a variety of head and neck sites and site‐specific relapse rates are summarized. New cases of small cell carcinoma arising in the hypopharynx, paranasal sinus, and from an unknown primary are added to the reported experience in the literature.
Hemimandibulectomy without bone grafting: Report of a case
Authors: Lambert Paul M. , Patel Mahendra 
Published: February 2007

AbstractSome patients require hemimandibulectomy who are poor candidates for reconstructive surgery or who do not want to subject themselves to multiple surgical episodes. With the use of an articulated external skeletal fixation appliance, near‐normal esthetics and function can be achieved in these patients without bone grafting. A report of one such case is presented.
Mucoepidermoid carcinoma of salivary glands: A clinicopathologic study of 46 cases
Authors: Nascimento Antonio G. , Amaral Ana Lucia P. , Prado Lygia Anne F. , Kligerman Jacob , Silveira Telma Ruth P. 
Published: February 2007

AbstractForty‐six cases of mucoepidermoid carcinoma (MEC) of the salivary glands were reviewed with an emphasis on the clinicopathologic aspects and prognosis of the tumors. MEC occurred in a wide age range, with few cases being diagnosed in childhood. Its peak of incidence was in the fifth decade and it involved major and minor salivary glands with equal frequency; the parotid gland was the gland most commonly affected. Presence of a mass was the most common complaint of all 46 patients. About 64% of the patients presented with stages 3 and 4 disease. Three distinct histologic grades were found after analyzing cellular pleomorphism, mitotic activity, and presence of necrosis. This study showed that clinical staging and histologic grading are the most important factors influencing survival and they seem to be independent of each other. Other variables found to be important in prognosis were age, sex, and the development of recurrent disease after surgery. Surgery with total resection of the tumor was the most effective treatment in our cases and adjuvant radiotherapy proved to be of little value in improving survival of MEC in our series of cases, considering that the patients in whom this type of treatment was used had unfavorable clinicopathologic factors.
Pharyngolaryngoesophagectomy with pharyngogastric anastomosis for cancer of the hypopharynx: Review of 101 operations
Authors: Harrison D. F. N. , Thompson A. E. 
Published: February 2007

AbstractDuring the period between 1965 and 1983, 101 pharyngolaryngoesophagectomies with primary pharyngogastric anastomosis were carried out for primary hypopharyngeal cancer at The Royal National Throat, Nose and Ear Hospital, London, England. The Hospital mortality rate was 11%; postoperative complications such as pleural effusion and regurgitation of bile occurred in all patients. Successful swallowing occurred in all patients before they left the hospital‐usually within 2 wk of surgery. An actuarial survival rate of 58% was obtained for the entire group.
Cold nodules of the thyroid: Current treatment
Authors: Rothenberg Robert E. , Laraja Raymond D. , Lobbato Vincent J. , Radulescu Valentin O. 
Published: February 2007

AbstractWithin recent years differing approaches to the treatment of cold nodules of the thyroid gland have evolved. To assess these differences and to discover whether a general consensus exists, questionnaires were sent to professors of surgery and endocrinology and to chiefs of head and neck sections at various medical colleges and university hospitals throughout the country. Fifty‐three surgeons and 13 endocrinologists answered the questionnaires and their responses are analyzed and recorded here.
Impact of smoking and smokeless tobacco on the risk of cancer of the head and neck
Authors: Stockwell Heather G. , Lyman Gary H. 
Published: February 2007

AbstractA case‐control epidemiologic study was conducted to determine the relationship between quantities and types of tobacco and the risk of cancers of individual sites within the head and neck. Substantial variations were found to exist in the tobacco‐associated risk for each site. The use of cigarettes was associated with an increased risk of cancers of all sites, except the salivary glands. Cancers of the floor of the mouth and larynx exhibited the highest cigarette‐related risks. Cigar smokers experienced excess risks of cancers of the tongue, pharynx, and larynx. Pipe smokers experienced elevated risks of cancer of the tongue, mouth, pharynx, and larynx. Among users of smokeless tobacco, increased risks of cancer of the mouth and gum, pharynx, and salivary glands were observed.
Lymphocyte phenotypes at tumor margins in patients with head and neck cancer
Authors: Guo Min , Rabin Bruce S. , Johnson Jonas T. , Paradis Irvin L. 
Published: February 2007

AbstractLymphocyte phenotypes were identified by monoclonal antibodies and avidin‐biotin peroxidase reagents and enumerated in tumor tissue removed from 26 patients with head and neck cancer. T lymphocytes (T11) were the predominate phenotype at the tumor margin, with twice as many helper/inducer (T4) as suppressor/cytotoxic (T8) lymphocytes. Patients with Stage II and III carcinoma of the glottis, tongue, and hypopharynx had significantly increased numbers of all T lymphocyte phenotypes when compared to patients with Stage IV disease, thus achieving statistical significance for the T11 and T8 phenotypes. All patients were followed for 2.5 years; those patients who remained free of malignant disease had an increased number of all T lymphocyte phenotypes compared to patients with recurrent malignancy, but this did not achieve statistical significance. Thus, increased numbers of 111 positive lymphocytes of both the T4 and T8 subsets in the tissue at the margins of head and neck tumors were associated with a more favorable prognosis. These results support the concept of an immunologic reaction at the tumor margin, which may be limiting the growth and spread of tumor.
Ultrasound B‐scans in the follow‐up of head and neck tumors
Authors: Westhofen Martin 
Published: February 2007

AbstractIn recent years, diagnostic ultrasound has become established in head and neck surgery. Modern equipment allows high resolution imaging of neck tissue masses, cervical vessels, and lymph nodes. The major advantage of B‐mode sonography is its ability to detect neoplasms in solid scarred neck tissue, commonly seen in patients with radical neck surgery. Postoperative or radiogenic edema, tumor recurrence, and lymph node involvement can be differentiated. Inflammatory and neoplastic lymph node diseases detected by echography must be differentiated by biopsy. Tumor recurrence was seen in 21 of 152 patients by echography. Twelve patients were diagnosed by clinical examination and 17 were diagnosed by computed tomography. Two false positive and one false negative sonographic diagnoses were made. B‐mode sonography is an important instrument in the follow‐up examination of head and neck tumors for early detection of tumor recurrence or tumor persistence.
Pharyngoesophageal diverticulum complicated by squamous cell carcinoma
Authors: Zitsch Robert P. , O'brien Christopher J. , Maddox William A. 
Published: February 2007

AbstractPharyngoesophageal (Zenker's) diverticulum is a relatively common acquired codition that may cause dysphagia and regurgitiation of food. Squamous carcinoma mayi develop in such a dverticulum, but this complication is exceedingly rare and may not be suspected preoperatively. This report describes a case in which the diagnosis of squamous carcinoma was made after regurgitation of malignant tissue from a radiographically proven pharyngoesophageal diverticulum. The patient was treated by simple diverticulectomy and postoperative radiation therapy.
Hibernomas of the head and neck
Authors: Abemayor Elliot , McClean Patrick H. , Cobb Camilla J. , Hashimoto Claire H. 
Published: February 2007

AbstractHibernomas are rare tumors derived from brown adipose tissue, a specialized form of fat tissue found in hibernating and nonhi‐bernating animals. Only a minority of reported hibernomas have occurred in the head and neck region. This report describes two cases of cervical hibernomas, one of which was preoperatively diagnosed by the use of fine‐needle aspiration biopsy. The clinical and pathologic characteristics of this neoplasm are reviewed. In general, hibernomas are slow‐growing tumors with inconclusive evidence for the existence of a malignant variant. A review of the literature supports the conclusion that excision, sparing vital structures, appears to be curative.
Squamous cell carcinoma of the pyriform sinus: Retrospective study of 351 cases treated at the institut Gustave‐Roussy
Authors: Vandenbrouck C. , Eschwege F. , De Rochefordiere A. La , Sicot H. , Mamelle G. , Le Ridant A. M. , Bosq J. , Domenge C. 
Published: February 2007

AbstractThe first part of the study was devoted to 199 tumors treated by surgery, either conservative for the smallest tumors (18 cases) or radical (181 cases), with systematic postoperative radiotherapy. The 3‐year survival rate was 48% and the 5‐year, 33%, with a 12% local recurrence rate, a 7.5% neck recurrence rate, and 27.6% rate distant metastases. Histologic correlations were developed. The second part of the study reported 152 cases treated by external radiotherapy alone either as a variant of our treatment protocol for the small‐sized tumors (31 cases) or, for the major part (121 cases), as a result of surgical inoperability or patient refusal. The former subgroup had a variable survival rate (65% at 3 years and 40% at 5 years) equivalent to similarly staged patients treated with conservation laryngeal surgery, whereas the prognosis of the latter subgroup was poor. The two main causes of failure were the inability to apply the curative treatment protocol in 35% of patients ineligible for a surgery and the high risk of distant metastases in the 65% of patients able to undergo the usual management.
Combined radiation therapy and surgery in the management of advanced head and neck cancer: Final report of study 73–03 of the radiation therapy oncology group
Authors: Kramer Simon , Gelber Richard D. , Snow James B. , Marcial Victor A. , Lowry Louis D. , Davis Lawrence W. , Chandler Richard 
Published: February 2007

AbstractBetween March 1973 and June 1979, patients with advanced operable squamous cell carcinoma of the supraglottic larynx or hypopharynx were randomly allocated to receive either preoperative radiation therapy (5,000 rad) or postoperative radiation therapy (6.000 rad). Patients with oral cavity or oropharynx lesions were randomly assigned either preoperative radiation, postoperative radiation, or definitive radiatio therapy (6,500–7,000 rad), with surgery reserved for slavage if residual disease was present 6 weeks after completion of irradiation. Three hundred twenty patients were evaluable with a median follow‐up of 60 months. Based on results in 277 patients across all four region combined, locoregional control was significantly better for patients assigned to receive psotoperative radiation therapy (65%) compared with those assigned to receive preoperative radiation therapy (48%,P=0.04). This was due to higher rate of both persistent and recurrent local and regional disease in the preoperative group. Survival also showed a trend to be better in the postoperative group (38%) compared with the preoperative group (38%) compared with the preoperative group (33%,P= 0.10). Rates of severe surgical and radiation therapy complications were similar overall. Forty‐three patients were evalauble for each of the three treatment regimens assigned to patients with oral cavity or oropharynx lesions. Due to the small number of patients available for this portion of the trial, the observed differences for overall survival (4‐year percentage 33% overall; 30% preoperative, 36% postoperative, 33% definitive radiation therapy) and for locoregional control (45% overall; 43% preoperative, 52% postoperative, 38% definitive radiation therapy) were not statistically significant. The use of definitive radiation therapy with surgical rescue as an ethically justified alternative treatment for these tumors remains a question for further research.
Osteonecrosis: Study of the relationship of dental extractions in patients receiving radiotherapy
Authors: Epstein Joel B. , Rea Giuseppe , Wong Frances L. W. , Spinelli John , Stevenson‐ Moore Peter 
Published: February 2007

AbstractOsteonecrosis is a severe complication of radiotherapy for cancer. Prevention of osteonecrosis is most important, as the condition may be chronic, progressive, and lead to pathologic fracture. The clinical experience, of 627 dental extractions at the Cancer Control Agency of British Columbia either before or after radiotherapy is presented.
Carcinoma of the prostate metastatic to the maxillary antrum
Authors: Har‐El Gady , Avidor Irena , Weisbord Arie , Sidi Jack 
Published: February 2007

AbstractMetastatic carcinoma of the maxillary antrum is an extreme rarity. Until 1980, less than 100 cases with distant primaries metastatic to the entire sinonasal tract had been reported. In a review of these cases, we found no mention of primary prostate cancer metastatic to the antrum. The purpose of this paper is to document the first case of this entity.
Long‐term effects of orbital irradiation
Authors: Guyuron Bahman , Dagys Arlene P. , Munro Ian R. 
Published: February 2007

AbstractThis retrospective study is a review of 18 patients who received radiotherapy to the orbit between the ages of 1 month and 10 years. Patients were followed for 7–21 years in an attempt to define the effects of orbital irradiation on a growing child. None of the patients in the study was spared injurious effects on soft tissue or bone, but soft tissue appeared to be more vulnerable to radiation than bone. Orbital irradiation caused soft tissue deficits of the upper face in 100% of the patients. Sixty‐seven percent of patients had soft tissue deformities of the midface, and 13% had soft tissue deformities of the lower face. Bony deficits were found in the upper face in 67% of the patients, the midface in 50%, and the lower face in 6%. This study found no correlation between age and time of radiotherapy on the effects of facial growth.