bluuebunny/crossref_metadata_2025_split huggingface dataset:
Childhood urogenital sarcoma
Authors: Weissman M. J. , Gaeta J. F. , Albert D. J. 
Published: February 2007

AbstractA review of the five cases of urogenital sarcoma in childhood seen from 1960 to 1970 at Roswell Park Memorial Institute is presented. The courses of three patients with rhabdomyosarcoma of the prostate is instructive in indicating the value of aggressive combination therapy. One patient is apparently free of disease three months after the completion of radiotherapy, dactinomycin and vincristine. The first reported case of leimyosarcoma of the testicle is presented, with the indications for retroperitoneal node dissection and radical local resection given. The 30 month survival supports the use of intensive chemotherapy for sarcoma of the scrotal contents. A cure is reported in a case of mesoblastic nephroma of the newborn. The entity is discussed and agreement indicated with the commonly held opinion that postoperative radiotherapy and chemotherapy are not necessary.
Isolation and radioimmunoassay of human transplantation antigens
Authors: Tanigaki N. , Miyakawa Y. , Kreiter V. P. , Pressman D. 
Published: February 2007

AbstractA procedure has been developed for the isolation of relatively pure human transplantation antigens in high yield from established cultures of human hematopoietic cells. Several preparations of soluble cell fragments, each carrying as the evident activity one of the specificities, HL‐A1, HL‐A2, and HL‐A7, have been isolated in a state of high molecular purity and high specific activity. Cell particulates, obtained by the disruption of cells when they were agitated in buffer, were digested under carefully controlled conditions with papain in the presence of cysteine. The soluble fragments obtained were carried through a series of purification steps‐hypotonic dialysis, DEAE ion exchange chromatography, ultrafiltration, gel filtration, and column elec‐trophoresis. The final preparations contained 30–37% of the total HL‐A activity present in the papain digest. All fragments carrying HL‐A activities had a molecular size of about 48,000 Daltons. Some of the HL‐A specificities were associated with differences in electrophoretic mobility of the fragments, and, on this basis, different specificites found in a single cell line could sometimes be separated from each other. The products were labeled with radioiodine without affecting the antigenic activity. These labeled antigens were used for a number of purposes. The chief application has been as a reagent in a sensitive radioimmunoassay method for HL‐A activity that is applicable to whole cells or particulates as well as to soluble antigens.
An appraisal of histiocytosis‐X
Authors: Kaplan Carl , Shamoto Mikihiro , Katoh Arthur 
Published: February 2007

AbstractA case of Hand‐Schüller‐Christian disease with a nineteen year follow‐up is presented, with lesions localized to the skull and mandible. Three separate courses of irradiation therapy produced temporary recalcification of the cranial defects. A skull biopsy obtained nineteen years after onset from a recurrent skull lesion disclosed an eosinophilic granuloma. Electron microscopic examination of this tissue revealed Langerhans cell granules identical to those we had previously described in a fatal case of Letterer‐Siwe disease, and as reported in other cases of histiocytosis‐X.The findings noted in this case support Lichtenstein's thesis of a probable common etiology for the group of syndromes he has designated as histiocytosis‐X, and also add support to Lieberman's findings of relatively benign disease in the reticuloendothelioses classified as eosinophilic granuloma.
Comparison of the effect of three nucleosides and a liver emulsion upon the inhibition of cancer in mice
Authors: Strong Leonell C. , Matsunaga Henry 
Published: February 2007

AbstractThe sum total of inhibition of growth capacities of spontaneous tumors in mice obtained with three nucleosides used separately is similar to, if not identical, with the amount of inhibition obtained by the use of the original liver emulsion. There is also clear evidence that most of this tumor inhibition is brought about by 5 methyl cytidine (0.02 molar concentration administered intraperitoneally three times weekly with a maximum injection of a volume of 0.05 cc). Adenosine is not only an inhibitor of cancer in mice but, under certain conditions, also a stimulator (0.05 molar percentage solution with maximal injections at any one time of 0.05 cc volume). This conversion of an inhibitor of cancer to a stimulator has been brought about by aging of the solution but how the conversion takes place is not known. However, this conversion of the effect of adenosine was obtained by the same procedure that the inhibitor of cancer in the liver emulsion can be converted to a stimulator of cancer.
Genetic predisposition to carcinoma of the breast: Multiple human genotypes for estrogen 16 alpha hydroxylase activity in caucasians
Authors: Lemon Henry M. 
Published: February 2007

AbstractThe ratio of administered estrioVestrone or estradiol 178 modifies the uterotropic action of estrogen upon uterine growth i n spayed rodents in vivo and the binding of tritiated estrone or estradiol to uterine and mammary estrogen receptor proteins in vivo and in vitro. Caucasian women with untreated breast cancer excrete significantly lower urinary ratios of estrioVestrone + estradiol (estriol quotient, Eq) compared to age‐matched noncancerous women. Pregnancy, which induces a 10‐fold augmentation of estriol production from fetoplacental sources above that of estrone and estradiol, significantly reduces human breast cancer risk.
Effects of irradiation on malignant cell cytoplasm
Authors: Barone Robert M. , Das Gupta Tap As K. 
Published: February 2007

AbstractWalker‐256 carcinoma was transplanted subcutaneously in the dorsum of male Sprague‐Dawley rats weighing 100 to 120 gm. The tumors were allowed to grow to 1 cm in diameter. The animals were divided into experimental and control groups. The tumors in the experimental animals were irradiated shielding the rest of the animals, the dose ranging from 50 to 2,000 rads. Specimens were dissected from the irradiated tumors at intervals of 1, 2, 4, 12, 24, and 48 hours, and one week and two weeks after irradiation, and from the control animals at the same intervals. Light microscopy showed no cytoplasmic changes in the irradiated group when the dose was less than 500 rads. With 1,000‐ and 2,000‐rad doses the nuclear profile changed and cytoplasmic basophilia was diminished. Enzyme histochemical studies showed diminution of succinic dehydrogenase and coenzyme I and II as the dose was increased to 2,000 rads, starting 24 hours after irradiation, with marked diminution on the seventh day. The hydrolytic enzyme activities were not altered with a dose up to 1,000 rads. With a 2,000‐rad dose, diminution of acid phosphatase activity was seen one week after irradiation. The cytoplasm of the tumor cells in the irradiated group showed diminution in the mitochondrial and microsomal population, most marked when the dosage was increased to 2,000 rads, and one week after irradiation. On the basis of our results it can be proposed that radiosensitivity of a malignant cell in an experimental system is largely dependent on the cytoplasmic organelles.
Regression of established methylcholanthrene tumors by intratumor injections of vibrio cholerae neuraminidase
Authors: Simmons Richard L. , Rios Angelyn , Ray Prasanta K. 
Published: February 2007

AbstractMethylcholanthrene fibrosarcomas were transplanted into syngeneic C3H/HeJ mice. When the tumors had become firmly established and were palpable, injections of Vibrio cholerae neuraminadase were made directly into the tumor mass. Growth generally stopped in the injected tumors and a number of tumors totally regressed. In animals bearing bilaterial immunologically identical tumors, injection of one tumor with Vibrio cholerae neuraminidase induced the regression not only of the injected tumor, but also of the contralateral tumor. When the bilateral tumors were of different types, injections of one did not lead to regression of the other but the animals were still capable of rejecting the injected tumor while dying of the immunodistinct untreated tumor.
Obstructive jaundice in macroglobulinemia
Authors: Elias Elias G. , Holyoke E. Douglas , Mittelman Arnold 
Published: February 2007

AbstractDysproteinemias usually present with bleeding from mucosal membranes. It has never been reported to cause hemobilia. We are reporting two cases of macroglobulinemia that presented with obstructive jaundice secondary to hemobilia. Although we are not sure of the source of the hemobilia, cholecystectomy and removal of the blood clots from the common bile duct resulted in alleviation of jaundice and no further gross biliary bleeding. There was no recurrence of jaundice in either case in one year and eight months respectively.
Tumor associated antigen in the chemotherapy of solid tumors
Authors: Mulcare R. , Lo Gerfo P. 
Published: February 2007

AbstractTen patients receiving systemic chemotherapy for metastatic tumors of the G. I. tract and lung are studied with serial determinations of TAA levels during their therapy. The pattern of changes of TAA levels in each patient is correlated with the clinical response of that patient. Significant decreases in TAA levels occurred concomitant with clinical improvement in three patients. Significant, sustained elevations in TAA levels were invariably associated with inexorable deterioration clinically. This occurred in 6 patients.This preliminary study suggests positive correlations may be present which would make serial TAA levels a useful guide to the effectiveness of chemotherapy in solid tumors.
The therapy of osteogenic sarcoma: Current status and thoughts for the future
Authors: Friedman Michael A. , Carter Stephen K. 
Published: February 2007

AbstractOsteogenic sarcoma is a rare but virulent malignancy for which significant prognostic factors have been identified. Evaluating the site, histology, size, and immunologic factors can help identify those patients at higher risk of recurrent disease. Surgical amputation is the mainstay of therapy for appropriate candidates (20% 5 year survivals). Radiation therapy alone yields 13%, and combined with surgery, 20% 5 year survivals. The efficacy of chemotherapy has not been fully evaluated but adriamycin and methotrexate have demonstrated activity of a promising degree. A protocol design to quickly and efficiently determine effective therapy for this disease could include pretherapeutic stratification, controlled trials of drugs or immune adjuvants with reevaluation at specific intervals of clinical significance.
The response of the stilbestrol‐induced renal tumor to chemotherapeutic agents
Authors: Dekernion Jean B. , Resnick Martin L. , Persky Lester 
Published: February 2007

AbstractThe inhibition of growth of the stilbestrol‐induced hamster kidney tumor by various chemotherapeutic agents was studied in vivo. 5‐Fluorouracil significantly retarded tumor growth and prolonged survival of the treated animals. The antibiotics mithramycin and dactinomycin markedly inhibited the tumor but did not prolong survival. The absence of drug toxicity in the doses used indicated that a more pronounced effect might have been obtained by retreatment at regular intervals. Cyclophosphamide at standard dosage levels did not influence tumor growth rate. The effect of vinblastine could not be properly assessed because of severe drug toxicity.
Continuous intravenous fucose therapy in rat mammary cancer II
Authors: Mullen James L. , Rosato Francis E. , Allen Terry R. , Miller Elizabeth E. , Roseman James , Rosato Ernest F. 
Published: February 2007

AbstractTwenty‐five Lewis‐Wistar rats, weighing 500 to 525 gm each, received a transplantable mammary tumor which spontaneously arose in this strain; two days later, they were equipped with a silastic catheter inserted into the superior vena cava, the catheter protected by a specially designed harness allowing unrestricted movement of the animals.On the fifth day after tumor implantation, continuous intravenous infusions were begun, five rats serving as control and receiving only saline, twelve rats receiving glucose and eight rats receiving fucose.All 25 animals tolerated the procedure with no toxicity in any group as determined by animal inspection, measurement of blood urea nitrogen and of serum glutamic pyruvate transaminase. There was no significant weight change during the course of the experiment.On completion of infusion, tumors in rats receiving 20% fucose showed a statistically significant smaller mean diameter as compared to both controls and rats receiving intravenous glucose. After cessation of the ten‐day infusion the tumors in the fucose‐treated rats remained significantly smaller than those in their glucose counterparts or controls. Attendant on intravenous fucose therapy was a definite increase in total oral intake and urinary output. Twenty‐one days after conclusion of intravenous therapy all animals were sacrificed, and the tissues of those who received fucose were found to have a statistically significantly increased level of serum protein‐bound fucose.
Stereotactic hypothalamotomy for the alleviation of pain in malignant tumors
Authors: Fairman David 
Published: February 2007

AbstractIn this paper the results of hypothalamotomy in 12 cases out of our series of 155 consecutive thalamic tractotomies are discussed. Satisfactory relief of pain was obtained in 80% of the cases with no operative mortality and a 10% of reversible complications. The pain relief lasted for the complete period of survival. A marked increase of appetite was observed in six of the cases with a definite improvement of the cachectic syndrome. A working hypothesis is presented based on phylogenetic and neurophysiological experimental work.
The pathophysiology and therapy of empyema in the isolated bladder
Authors: Mebust Winston K. , Valk W. L. , Foret John D. , Haskins Robert 
Published: February 2007

AbstractTwenty to thirty percent of patients who have had supervesical urinary diversion with the bladder left behind subsequently develop empyema of the isolated bladder. The following study was undertaken in a series of 36 female dogs divided into three groups to determine the role of infection and obstruction in the partial and completely obstructed isolated bladder. From these studies a model was selected to evaluate various therapeutic regimens.
Esophageal cancer: Results of therapy in an indigent population
Authors: Buck Bruce A. , Fletcher William S. 
Published: February 2007

AbstractThe Tumor Clinic charts of 118 patients with esophageal carcinoma were reviewed. Of these patients 101 had squamous cell carcinoma. All were from an indigent patient population, and had a high rate of alcoholism, heavy smoking, and malnutrition. Most of the patients presented with dysphagia or pain. However, on review, significant weight loss antedated these symptoms by many months. Earlier diagnosis might be achieved in many instances by a careful esophageal workup in those patients with unexplained weight loss. The duration of dysphagia does not correlate with length of survival after therapy. The data indicates that esophagectomy offers the best chance for cure, and longer significant palliation. The significant morbidity and mortality of this procedure in the malnourished patient can be minimized only by careful attention to operative technique. An experienced senior surgeon should attend this procedure when it is performed by resident surgeons in a teaching situation. Radiotherapy should be reserved for use as an adjuvant to surgery preoperatively, or for patients whose associated disease precludes surgical resection.
Pathologic changes in the human urinary tract due to anovulatory drug administration
Authors: Corriere Joseph N. 
Published: February 2007

AbstractA 31‐year‐old woman on oral contraceptives for three anda half years died of overwhelming sepsis. At autopsy, dilatation of the renal tubules and squamous metaplasia of the urinary bladder mucosa were found. These changes have been produced in animals with estrogen and estrogen‐progestogen medications but have not been previously reported in man. Published reports of the effects of these drugs on the urinary tract are reviewed and discussed.
Transmission and emission scintiphotography of the heart and mediastinum
Authors: Swann Sybil J. , Jones A. Eric , Johnston Gerald S. 
Published: February 2007

AbstractRadiosotopic imaging of the mediastinal blood pools is a well established technique. Although the method provides data relating to the size and location of these pools, additional valuable diagnostic information can be easily obtained through transmission scintigraphy performed prior to blood pool imaging. From an appropriate external radionuclide source, the radiation passes through the radiolucent chest structures to a gamma camera forming an outline image of the more radiodense structures. Subsequent to the transmission study, an emission study of mediastinal blood pools is obtained. The transmission and emission images are similar in size and directly comparable for evaluation of mediastinal structures. The routine use of radionuclide transmission scintigraphy is recommended as an adjunct to emission scintigraphy in the evaluation of mediastinal tumors, myocardial hypertrophy, and pericardial effusions.
Comparative effect of three nucleosides on suppression of cancer growth in mice
Authors: Strong Leonell C. , Matsunaga Henry 
Published: February 2007

AbstractIt has been determined that three nucteosides, which were found in a liver emulsion, have effects on the growth of spontaneous tumors in mice. An 0.05 molar solution of adenosine inhibits the growth of spontaneous tumors in 5–8 month old mice but not in one aged 9–12 months. An 0.08 molar solution of 6‐methyl adenosine also inhbits the growth of spontaneous tumors in 5–8 month old mice but not in one aged 9–12 months. An 0.02 molar solution of 5‐methyl cytidine is a powerful inhibitor of spontaneous tumors in mice irrespective of age of host. The differential effect of the three nucleosides upon the growth of spontaneous tumors may be conditioned by a differential rapidity of growth of cancer depending upon the age of the cancer proband. That is, the age of the cancer probund may effect the growth capacity of a spontaneous tumor and its response to a nucleoside.
Increasing the efficiency of cancer chemotherapy with heparin: “Clinical study”
Authors: Elias Elias G. , Sepulveda Federico , Mink Irving B. 
Published: February 2007

AbstractAnticoagulation with heparin did not prevent tumor growth in man. Cancer chemotherapy became more effective when delivered to the patients after they became anticoagulated. Patients who had metastatic diseases and elevated plasma fibrinogen showed initial resistance to the anticoagulating effect of heparin.
Biochemical and metabolic function of the canine liver after four hours preservation
Authors: Sampson D. , Depasquale J. L. , Murphy G. P. 
Published: February 2007

AbstractCanine livers were stored for four hours with either hypothermia alone, hypothermia and low flow electrolyte perfusion, hypothermia low flow plasma perfusion, or normothermic dilute blood perfusion. The livers were evaluated by a subsequent two hour normothermic dilute blood test perfusion. Pressure flow relationships were of value in assessing the adequacy of the storage, and correlated well with glucose production and ultrastructural appearances. Livers stored with plasma perfusion seemed to be the most satisfactory. Anaerobic utilization of fructose was a more sensitive index of cellular damage than oxygen uptake in manometric studies. Bromsulphthalein clearance during the test perfusion was of limited value.
Skin test in bronchogenic carcinoma: II. Its value in the differential diagnosis
Authors: Brugarolas Antonio , Takita Hiroshi , Vincent Ronald G. 
Published: February 2007

AbstractPreviously, we observed close relationship between impairment of reaction to delayed hypersensitivity skin test and extent of bronchogenic carcinoma patients. Recently 3 patients with suspected carcinoma of the lung with hematogenous metastases demonstrated excellent reaction to the skin tests contrary to our past experience. Further work up demonstrated that these patients had primary carcinoma other than the lung in origin. The cases are reported to emphasize again the importance of skin tests in bronchogenic carcinoma.
Kangri cancer in kashmir valley: Preliminary study
Authors: Suryanarayan Col. C. R. 
Published: February 2007

AbstractThis type of cancer is peculiar to this region as the people of all age groups are accustomed to warm their bodies by the use of Kangri Baskets. This is seen mostly among the “not well‐to‐do classes” who have no other means of fighting the extreme cold during the winter. The ulcers are the result of continuous constant contact of the hot pot, made of mud, enclosed in a basket made of willow. The author has studied quite a number of cases in all age groups during his stay in the valley, and has noticed that the precancerous condition of pigmentation and rough skin in the users of this “Kangri pot” has certain manifestations. In due course, by further irritation by heat, the ulcer breaks down with secondary infection and malignant transformation. The squamous type of carcinoma of the skin at the site of the constant heat application exists at times without involving the adjacent lymph glands. The prognosis of the disease is worse when the infiltration of cancer involves the lumph glands. It is also clearly brought out that this type of cancer is entirely due to the environmental causes, which could be prevented. The victims, in addition, are anemic due to worm infestations in their system (round and hookworms). The secondary infection of ulcer and glands is accentuated by the poor hygience which also increases the morbidity and mortality of these cases. The treatment of this condition has to be done first to combat the anemia due to worms by deworming the patients, combating the secondary infection by antibiotics, and, finally, by certain herbs, chemotherapeutic drugs, and radioactive isotopes. The surface application of radioactive isotopes in early ulcers is useful. Deep x‐ray therapy also has been tried. The intra‐lymphatic perfusion of radioactive isotopes combined with cehmotherapeutic drugs for those cases involving the lymph glands have shown good results.
Incidence of hyperfibrinogenemia in 1961 patients with cancer
Authors: Brugarolas A. , Elias E. G. 
Published: February 2007

AbstractThe incidence of hyperfibrinogenemia was studied in 1961 patients with different malignancies. Hyperfibrinogenemia was found to be associated with rapidly growing tumors. On the one hand, carcinomas, sarcomas, and Hodgkin's disease presented hyperfibrinogenemia very frequently. On the other hand, chronic leukemias and lymphosarcomas seldom presented hyperfibrinogenemia. This study confirms that hyperfibrinogenemia and hypercoagulability might play a role in the growth of tumors and indicates the tumors more suitable for future prospective studies.