bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stereocontrolled Reactions Mediated by Remote Sulfoxides: Formation and Reactivity of Enantiomerically Pure Benzylic Centers
Authors: Garcia Ruano Jose Luis Garcia Ruano Jose Luis , Martin Castro Ana M. 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Development of Odorless Organosulfur Reagents and Asymmetric Reaction Using Odorless Thiols
Authors: Node Manabu , Kajimoto Tetsuya 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Novel Cyclooxygenase‐Catalyzed Bioactive Prostaglandin F2α: From Physiology to New Principles in Inflammation
Authors: Basu Samar 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cysteinyl‐Leukotrienes and Their Receptors in Asthma and Other Inflammatory Diseases: Critical Update and Emerging Trends
Authors: Capra Valerie , Thompson Miles D. , Sala Angelo , Cole David E. , Folco Giancarlo , Rovati G. Enrico 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Matrix Metalloproteinase 11 (MMP‐11; Stromelysin‐3) and Synthetic Inhibitors
Authors: Matziari Magdalini , Dive Vincent , Yiotakis Athanasios 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemical Modification of Therapeutic Drugs or Drug Vector Systems to Achieve Targeted Therapy: Looking for the Grail
Authors: Juillerat‐Jeanneret L. , Schmitt F. 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Sequences, Constituents, and Producers of Peptaibiotics: An Update Review
Authors: Degenkolb Thomas , Kirschbaum Jochen , Brueckner Hans 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Safety Evaluation of Tissue Engineered Medical Devices Using Normal Human Mesenchymal Stem Cells
Authors: Sawada Rumi , Ito Tomomi , Tsuchiya Toshie 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Neutral—Neutral Gas‐Phase Reactions in Extraterrestrial Environments: Laboratory Investigations by Crossed Molecular Beams
Authors: Balucani Nadia , Casavecchia Piergiorgio 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Mechanisms of the Gas‐Phase Reactions of Aromatic Hydrocarbons and PAHS with OH and NO3 Radicals
Authors: Atkinson Roger , Arey Janet 
Published: September 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chirality sensing of fullerenes using cyclic hosts having a chiral N‐substituted porphyrin: A remote substituent effect
Authors: Shoji Yoshiaki , Tashiro Kentaro , Aida Takuzo 
Published: September 2007

AbstractCyclic host molecules 12H and 22H, having a chiral N‐methylporphyrin unit, include C76 in their asymmetrically distorted π‐electronic cavity and are capable of spectral discrimination of the enantiomers of C76 by means of 1H NMR. Although the only structural difference between 12H and 22H is in the para‐substituents R on their meso‐phenyl groups, the association constant of C76 with 12H is more than twice as large as that with 22H. The ΔH values for the association of C76 with these hosts are hardly different from one another, but a rather big difference exists in their ΔS values (12H, −17.7 ± 0.7 J mol−1; 22H, −26.3 ± 1.0 J mol−1). The difference in ΔS is most likely due to a steric effect of the substituents on the conformational freedom of the hexamethylene linkers. Although the R groups are topologically remote from the binding site, they also affect the resolution of the diastereoisomerically split N‐Me signals in the 1H NMR spectra of the hosts upon inclusion of C76. Chirality, 2008. © 2007 Wiley‐Liss, Inc.
Intraluminal Filling Defects on Coronary Angiography: More than Meets the Eye
Authors: Jaffe Ronen , Irfan Affan , Hong Tony , Chisholm Robert J. , Cheema Asim N. 
Published: September 2007

AbstractIntraluminal filling defects are occasionally encountered on coronary angiography and often related with coronary thrombi. However, other conditions affecting the coronary arteries may present with similar angiographic findings causing diagnostic uncertainty. Accurate characterization of the angiographic filling defect is critical, particularly in patients planned for a percutaneous coronary intervention (PCI), as diagnosis of a coronary thrombus not only increases the risk of post procedural adverse events but also requires a specific therapeutic approach. In this paper, we report three patients in whom coronary angiography revealed intraluminal filling defects mimicking coronary thrombi. When further investigated with intravascular ultrasound (IVUS) as a part of the planned PCI, the thrombus was excluded and alternate etiology of the filling defect was confirmed in all patients. The angiographic “pseudothrombi” were produced by coronary dissection in one and by heavy calcification within the atherosclerotic plaque in two patients. The use of IVUS allowed accurate characterization of the angiographic filling defect and provided important information to guide management and optimize therapeutic approach. Copyright © 2007 Wiley Periodicals, Inc.
Computerized Acoustic Cardiographic Insights into the Pericardial Knock in Constrictive Pericarditis
Authors: Michaels Andrew D. , Viswanathan Mohan N. , Jordan Mark V. , Chatterjee Kanu 
Published: September 2007

AbstractBackgroundOne of the clinical hallmarks of constrictive pericarditis is the pericardial knock, a high‐pitched early diastolic heart sound. Making the clinical diagnosis of constrictive pericarditis is challenging, as is accurate auscultation of the pericardial knock.HypothesisWe sought to assess the utility of a computerized acoustic cardiographic device in the assessment of the pericardial knock in patients with constrictive pericarditis.MethodsWe report a case series in which computerized acoustic cardiography (Audicor, Inovise Medical Inc., Portland, OR) is performed in patients with constrictive pericarditis.ResultsThree patients with constrictive pericarditis underwent computerized acoustic cardiographic recordings at the time of cardiac catheterization. In each case, initial physical examination by the internist and referring cardiologist did not appreciate a pericardial knock. Acoustic cardiography demonstrated a high‐pitched early diastolic sound in each case. Time‐frequency representation analyses showed the high‐frequency components of the pericardial knock sound. Repeat acoustic cardiography demonstrated resolution of the pericardial knock after pericardiectomy in two patients.ConclusionsNon‐invasive computerized acoustic cardiography can demonstrate the high‐pitched pericardial knock in patients with constrictive pericarditis. This may aid the bedside assessment of patients with diastolic heart failure, improving the clinician's ability to appreciate the ausculatory findings in constrictive pericarditis. Copyright © 2007 Wiley Periodicals, Inc.
Effects of Atorvastatin on Coronary Flow Reserve in Patients with Slow Coronary Flow
Authors: Caliskan Mustafa , Erdogan Dogan , Gullu Hakan , Topcu Semra , Ciftci Ozgur , Yildirir Aylin , Muderrisoglu Haldun 
Published: September 2007

AbstractBackgroundStatins improve endothelial functioning in patients with coronary artery disease and hypercholesterolemia, while substantially little is known about induced changes in myocardial microcirculation. However, although previous studies have suggested that microvascular abnormalities and endothelial dysfunction is responsible for slow coronary flow (SCF), there is no study investigating possible effects of statins on coronary microvascular function in patients with SCF.HypothesisWe prospectively investigated the effects of short‐term lipid‐lowering therapy with atorvastatin on coronary flow reserve (CFR) reflecting coronary microvascular function in patients with SCF assessed by transthoracic Doppler echocardiography (TTDE).MethodsIn an open clinical trial, CFR was studied in 20 subjects with SCF. TTDE was used to assess CFR at baseline as well as after 8 weeks of atorvastatin therapy. Coronary flow was quantified according to TIMI frame count (TFC). Coronary diastolic peak flow velocities were measured at baseline and after dipyridamole infusion. CFR was calculated as the ratio of hyperemic to baseline diastolic peak velocities.ResultsCFR was independently correlated with TFC. After 8 weeks of atorvastatin therapy, CFR values increased significantly (1.95 ± 0.38 vs. 2.54 ± 0.56, (p < 0.001). No change in hemodynamic parameters was noted during the entire study. The improvement in CFR was not correlated to the amount of lipid‐lowering effect of atorvastatin.ConclusionsThese findings suggest that short‐term lipid‐lowering therapy with atorvastatin improved CFR, which reflects coronary microvascular functioning in patients with SCF. Copyright © 2007 Wiley Periodicals, Inc.
Glomerular Filtration Rate and Coronary Artery Disease Burden in Patients with Acute Coronary Syndrome
Authors: Nunes José Pedro L. , Faria Maria do Sameiro , Garcia J. M. Mota , Gonçalves Francisco Rocha 
Published: September 2007

AbstractBackgroundMild renal dysfunction may be associated with increased cardiovascular morbidity and mortality.MethodsThe relation between estimated glomerular filtration rate (eGFR), as calculated from plasma creatinine at admission, and coronary artery disease burden (CADB), was studied in a cohort of 110 patients with acute coronary syndrome and coronary atherosclerosis.ResultsA relatively weak but significant negative correlation was found between eGFR and CADB as measured by angiography (coefficient correlation of − 0.26, probability value of 0.006); a similar association was seen in multiple regression analysis, taking CADB as dependent variable, and eGFR, age, plasma calcium and plasma phosphorus as independent variables. After dividing the 110 patients into eGFR tertiles (with mean values of 102.9 ± 22.8, n = 37, 75.7 + or − 5.6, n = 36, and 53.1 ± 13.4, n = 37, all in mL/min per 1.73 m2), mean CADB values of the lower and higher eGFR tertiles were found to be significantly different (270.6 ± 176.4 and 192.9 ± 78.5, respectively). Similar mean values for CADB and for eGFR were noted when patients with elevated ST segment/new left bundle branch block and patients with nonelevated ST segment acute coronary syndrome were compared.ConclusionsWe conclude that renal function of patients with acute coronary syndromes and coronary atherosclerosis, as estimated at admission, is negatively correlated with coronary artery disease burden. It is unknown whether renal dysfunction acts as a cause for accelerated coronary artery disease or if it merely acts as a surrogate marker for the overall systemic vascular system status. Copyright © 2007 Wiley Periodicals, Inc.
The Role of Aspirin Resistance in the Treatment of Acute Coronary Syndromes
Authors: Lancaster Gilead I. , Jain Hitender , Zarich Stuart W. 
Published: September 2007

AbstractThe TIMI Risk Score recognizes prior aspirin use as an independent risk factor for adverse outcomes in subjects presenting with an acute coronary syndrome. The etiology of this increased risk awaits clarification, but prior aspirin use may be associated with altered thrombus composition which is more resistant to current treatment modalities as compared to thrombus formation in subjects without prior aspirin use. Post hoc analysis of acute coronary syndrome trials has shown that prior aspirin users treated with unfractionated heparin are at particularly high risk. The addition of glycoprotein IIb/IIIa receptor inhibitor to unfractionated heparin or substitution of low‐molecular‐weight heparin significantly improves outcomes in prior aspirin users. The prognostic significance of prior aspirin use in acute coronary syndromes has important implications not only in clinical practice, but also in the design and interpretation of clinical trials. Copyright © 2007 Wiley Periodicals, Inc.
Overcoming the Inadequacies or Limitations of Experimental Structures as Drug Targets by Using Computational Modeling Tools and Molecular Dynamics Simulations
Authors: Marco Esther , Gago Federico 
Published: September 2007

AbstractX‐ray crystallography, NMR spectroscopy, and cryoelectron microscopy stand out as powerful tools that enable us to obtain atomic detail about biomolecules that can be potentially targeted by drugs. This knowledge is essential if virtual screening or structure‐based ligand‐design methods are going to be used in drug discovery. However, the macromolecule of interest is not always amenable to these types of experiment or, as is often the case, the conformation found experimentally cannot be used directly for docking studies because of significant changes between apo and bound forms. Furthermore, sometimes the desired insight into the binding mechanism cannot be gained because the structure of the ligand–receptor complex, not having been time‐resolved, represents the endpoint of the binding process and therefore retains little or no information about the intermediate stages that led to its creation. Molecular dynamics (MD) simulations are routinely applied these days to the study of biomolecular systems with the aims of sampling configuration space more efficiently and getting a better understanding of the factors that determine structural stability and relevant biophysical and biochemical processes such as protein folding, ligand binding, and enzymatic reactions. This field has matured significantly in recent years, and strategies have been devised (for example activated, steered, or targeted MD) that allow the calculated trajectories to be biased in attempts to properly shape a ligand binding pocket or simulate large‐scale motions involving one or more protein domains. On the other hand, low‐frequency motions can be simulated quite inexpensively by calculation of normal modes which allow the investigation of alternative receptor conformations. Selected examples in which these methods have been applied to several medicinal chemistry and in silico pharmacology endeavors are presented.
Quality of Sleep in Hemodialysis Patients
Authors: Tel Havva , Tel Hatice , Esmek Mehtap 
Published: September 2007

AbstractBACKGROUNDHemodialysis patients frequently experience problems sleeping. The purpose of this study was to determine sleep quality in hemodialysis patients.METHODS AND MATERIALSA total of 150 patients under treatment with ongoing hemodialysis in a university hospital dialysis unit were included in the study. Data were collected with a personal information form and the Pittsburgh Sleep Quality Index (PSQI).RESULTSA total score greater than 5 on the PSQI indicates poor quality of sleep. It was determined that: all the hemodialysis patients complained of sleep problems; most (78.7%) reported poor sleep quality; as the patients' age and time on dialysis increased, their sleep quality decreased; there was a statistically significant difference in sleep quality according to sex and occupation (p < 0.05); patients who were female and housewives had worse sleep quality than the other patients; and sleep quality did not significantly differ by marital status or educational level (p > 0.05).CONCLUSIONIt was determined that all the hemodialysis patients complained of sleep problems and that most had poor quality of sleep. Interventions directed at eliminating hemodialysis patients' sleep problems will have a part in improving their quality of life.
Reversible Binding of Dihydrogen in Multimetallic Complexes
Authors: Weller Andrew S. , McIndoe J. Scott 
Published: September 2007

AbstractThe interaction of hydrogen with metal surfaces is one of the most important and fundamental processes in the chemical industry. Hydrogen is also strongly tipped to play a central role in new challenges that are emerging in terms of climate change and energy supply, and the reversible binding of H2 to suitable materials will play a keystone role in the realisation of the hydrogen economy. The reversible interaction of hydrogen with multimetallic centres is also an important theme in biological processes; the role of hydrogenases in the metabolism of H2 is an example. Thus the reversible interaction of H2 with multimetallic metal complexes is an area that spans considerable breadth. This review is concerned with the reversible interaction of H2 with soluble multimetallic complexes, defined broadly as clusters, in which there are no other ligands lost or gained in the process. The review is organised under the subheadings: equilibrium reversible (H2 is lost upon removal of the H2 atmosphere), thermally reversible or reversible when placed under vacuum, photochemically reversible and electrochemically reversible interactions; a brief outline of reversible H2 binding in systems of biological interest; giant metal clusters that display reversible H2 binding. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Light‐emitting diode‐compatible probes for indirect detection of anions in CE
Authors: Balding Peter , Boyce Mary C. , Breadmore Michael C. , Macka Mirek 
Published: September 2007

AbstractA range of compounds were evaluated as probes for the indirect detection of inorganic ions using CE and light‐emitting diodes (LEDs) as the light source. Emphasis was placed on examining probes likely to absorb strongly in the UV–Vis region near 350–430 nm as compounds, which absorb at longer wavelengths tend to be bulkier and adsorb onto the capillary wall. These probes should act as a replacement for the very effective but carcinogenic probe chromate. Two probes were identified and evaluated: p‐nitrophenol and 4‐hydroxy‐3,5‐dinitrobenzoic acid. The former showed the most potential with low‐mobility anions, while the later had a moderate electrophoretic mobility and was more suitable for a wider mobility range of analytes. However, neither could match the efficiencies and LOD of chromate for the separation of the fast inorganic ions such as chloride, nitrate and sulphate. Nevertheless, application of the 4‐hydroxy‐3,5‐dinitrobenzoic acid system to the determination of oxalate in Bayer liquors showed excellent sensitivity and selectivity.
An evaluation of the experimental approaches to detection of small ions in CE
Authors: Coufal Pavel , Pacáková Věra , Štulík Karel 
Published: September 2007

AbstractThis review points out some important trends in the development of the detection techniques for small ions in CE. On the basis of selected literature references it briefly discusses some general requirements on detection techniques in CE. Various optical measurements, mass spectrometric approaches and electrochemical detection techniques are dealt with. Some specific features of microchip CE separation and detection are pointed out and possibilities of dual detection are mentioned. The principal parameters of the above detection techniques are then briefly compared.
Determination of organic acids by CE and CEC methods
Authors: Klampfl Christian W. 
Published: September 2007

AbstractA comprehensive overview of the analysis of low‐molecular‐mass organic acids employing electromigration methods in the capillary format is given. This review includes papers published since 2003 and can be seen as an update of the review paper published by Galli et al. in 2003 [1]. Tables included in this review contain application papers describing the determination of organic acids from a variety of fields like the analysis of food and beverages, environmental samples, samples from clinical origin, and from natural products.
Simultaneous enantioseparation and sensitivity enhancement of basic drugs using large‐volume sample stacking
Authors: Deñola Nerissa L. , Quiming Noel S. , Saito Yoshihiro , Jinno Kiyokatsu 
Published: September 2007

AbstractSimultaneous enantioseparation with sensitive detection of four basic drugs, namely methoxamine, metaproterenol, terbutaline and carvedilol, using a 20‐μm ID capillary with native β‐CD as the chiral selector was demonstrated by the large‐volume sample stacking method. The procedure included conventional sample loading either hydrodynamically or electrokinetically at longer injection times without polarity switching and EOF manipulation. In comparison to conventional injections, depending on the analyte, about several hundred‐ and a thousand‐fold sensitivity enhancement was achieved with the hydrodynamic and the electrokinetic injections, respectively. The simple method developed was applied to the analysis of racemic analytes in serum samples and better recovery was achieved using hydrodynamic injection than electrokinetic injection.
Fitting observed and theoretical choices – women's choices about prenatal diagnosis of Down syndrome
Authors: Seror Valerie 
Published: September 2007

AbstractChoices regarding prenatal diagnosis of Down syndrome – the most frequent chromosomal defect – are particularly relevant to decision analysis, since women's decisions are based on the assessment of their risk of carrying a child with Down syndrome, and involve tradeoffs (giving birth to an affected child vs procedure‐related miscarriage). The aim of this study, based on face‐to‐face interviews with 78 women aged 25–35 with prior experience of pregnancy, was to compare the women' expressed choices towards prenatal diagnosis with those derived from theoretical models of choice (expected utility theory, rank‐dependent theory, and cumulative prospect theory). The main finding obtained in this study was that the cumulative prospect model fitted the observed choices best: both subjective transformation of probabilities and loss aversion, which are basic features of the cumulative prospect model, have to be taken into account to make the observed choices consistent with the theoretical ones. Copyright © 2007 John Wiley & Sons, Ltd.