bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supracricoid hemilaryngopharyngectomy in selected pyriform sinus carcinoma staged as T2
Authors: Laccourreye Ollivier , Mérite‐Drancy Agnés , Brasnu Daniel , Chabardes Eric , Cauchois Régis , Ménard Madeleine , Laccourreye Henri 
Published: October 2006

AbstractFrom 1964 to 1985 supracricoid hemilaryngo‐pharyngectomy (SCHLP) was performed at the authors' institution for 34 selected pyriform sinus carcinomas staged as T2. Tumors involved the anterior part of the pyriform sinus, the lateral wall, the medial wall, and the whole aryepiglottic fold in all cases. Tumors with invasion of the apex of the pyriform sinus, of the retrocricoid region, of the posterior pharyngeal wall, or with fixation of the true vocal cord were excluded from the study. Such a technique was aimed at preserving physiologic phonation, respiration, and swallowing while achieving the same local control rate as pharyngolaryngectomy. Patients were monitored for at least 6 years or until death. No patients were lost to follow‐up. The 5‐year cause‐specific survival rate was 55.8%. The main cause of death was second primary tumor. The 5‐year actuarial local recurrence rate was 3.4%. The authors' experience with the SCHLP technique challenges the traditional teaching of pharyngolaryngectomy and establishes this technique as a safe method of voice preservation in selected cases of pyriform sinus carcinomas.
Impact of Residence on Prevalence and Intensity of Prescription Drug Use Among Older Adults
Authors: Carrie Anita G , Grymonpre Ruby E , Blandford Audrey A 
Published: October 2006

Background: Higher levels of morbidity among older adults result in greater need for pharmaceutical products and pharmacy services compared with the need in the general population. Rural residents reportedly have reduced access to healthcare services secondary to transportation difficulties, a limited supply of healthcare workers and facilities, and financial constraints. Objective: To examine differences in the prevalence and intensity of prescription pharmaceutical use among urban and rural older adults in Manitoba, Canada. Methods: Participant data from the 1996/1997 Manitoba Study of Health and Aging were linked to pharmaceutical claims data recorded in Manitoba Health's Drug Program Information Network. The effect of residence on the prevalence and intensity of drug use was determined, in addition to the effects of other sociodemographic characteristics, measures of health, and health service utilization. Results: The prevalence of prescription pharmaceutical use did not differ between urban and rural residents (90.6% vs 89.5%, respectively; p = 0.60). Users of home-care services (OR 1.93; 95% CI 1.09 to 3.39), those who perceived their income as adequate (2.38; 95% CI 1.09 to 5.17), and those with a higher number of chronic health problems (1.42; 95% CI 1.26 to 1.62) were significantly more likely to access prescription medications. Rural and urban residents were equally likely to be high users of prescription drugs (21.3% vs 20.0%, respectively; p = 0.64). Conclusions: Poor health status is associated with a higher prevalence and intensity of use of prescription drugs among older Manitobans. Rural residence is not a barrier to receipt of prescription pharmaceuticals.
Assessment of the chemical quality of drinking water in Cambodia
Authors: Feldman Peter R. , Rosenboom Jan-Willem , Saray Mao , Samnang Chea , Navuth Peng , Iddings Steven 
Published: October 2006

Most water supply programmes in Cambodia have focused on providing access to bacteriologically safe water, an approach which has led to an increasing reliance on ground water, especially in rural areas. However, there have been very few data collected on the chemical quality of the nation's drinking water sources, and few water supply programmes have the capacity to assess chemical quality. The study was designed to address this data gap by conducting a low-cost, rapid assessment of drinking water sources nationwide to determine whether there were any chemicals of concern in Cambodian water supply sources. Results of the assessment confirm that there are several parameters of health and aesthetic concern; dissolved arsenic is the most significant. Elevated arsenic levels (some exceeding 500 μg l-1) were detected in aquifers of moderate depth in several highly populated areas, confirming that further investigation of the occurrence of arsenic contamination in Cambodia is warranted. Other chemicals of health concern include nitrate, nitrite, fluoride and manganese. Additionally, many ground water sources are negatively impacted by parameters of aesthetic concern, such as iron, manganese, hardness and total dissolved solids. Elevated levels of these parameters have caused consumers to reject newly installed water supplies, often in favour of surface water sources that are bacteriologically unsafe.
Field scale quantification of microbial transport from bovine faeces under simulated rainfall events
Authors: Ferguson Christobel M. , Davies Cheryl M. , Kaucner Christine , Ashbolt Nicholas J. , Krogh Martin , Rodehutskors Jörg , Deere Daniel A. 
Published: October 2006

The dispersion and transport of Cryptosporidium parvum oocysts, Escherichia coli and PRD1 bacteriophage seeded into artificial bovine faecal pats was studied during simulated rainfall events. Experimental soil plots were divided in two, one sub-plot with bare soil and the other with natural vegetation. Simulated rainfall events of 55 mm.h-1 for 30 min were then applied to the soil plots. Each experimental treatment was performed in duplicate and consisted of three sequential artificial rainfall events (‘Runs’): a control run (no faecal pats); a fresh faecal pat run (fresh faecal pats); and an aged faecal pat run (one week aged faecal pats). Transportation efficiency increased with decreasing size of the microorganism studied; Cryptosporidium oocysts were the least mobile followed by E. coli and then PRD1 phage. Rainfall events mobilised 0.5 to 0.9% of the Cryptosporidium oocysts, 1.3‒1.4% of E. coli bacteria, and 0.03‒0.6% of PRD1 bacteriophages from the fresh faecal pats and transported them a distance of 10 m across the bare soil sub-plots. Subsequent rainfall events applied to aged faecal pats only mobilised 0.01‒0.06% of the original Cryptosporidium oocyst load, between 0.04 and 15% of the E. coli load and 0.0006‒0.06% of PRD1 bacteriophages, respectively.
Health risks in wastewater irrigation: Comparing estimates from quantitative microbial risk analyses and epidemiological studies
Authors: Mara D. D. , Sleigh P. A. , Blumenthal U. J. , Carr R. M. 
Published: October 2006

The combination of standard quantitative microbial risk analysis (QMRA) techniques and 10,000-trial Monte Carlo risk simulations was used to estimate the human health risks associated with the use of wastewater for unrestricted and restricted crop irrigation. A risk of rotavirus infection of 10-2 per person per year (pppy) was used as the reference level of acceptable risk. Using the model scenario of involuntary soil ingestion for restricted irrigation, the risk of rotavirus infection is ~10-2 pppy when the wastewater contains ≤106Escherichia coli per 100 ml and when local agricultural practices are highly mechanised. For labour-intensive agriculture the risk of rotavirus infection is ~10-2 pppy when the wastewater contains ≤105E. coli per 100 ml; however, the wastewater quality should be ≤104E. coli per 100 ml when children under 15 are exposed. With the model scenario of lettuce consumption for unrestricted irrigation, the use of wastewaters containing ≤104E. coli per 100 ml results in a rotavirus infection risk of ~10-2 pppy; however, again based on epidemiological evidence from Mexico, the current WHO guideline level of ≤1,000 E. coli per 100 ml should be retained for root crops eaten raw.
Influence of the Organic Compounds on the Ecotoxicity in the Treatment of Foundry Sludge and Olive Mill Waste
Authors: Coz Alberto , Mantzavinos Dionisis , Karageorgos Petros , Kalogerakis Nikolas , Andrés Ana , Viguri Javier R. , Irabien Ángel 
Published: October 2006

AbstractThe study of the ecotoxicity in two industrial waste materials and the relationships with the organic parameters has been conducted. Foundry sludge and olive mill waste have been used as industrial waste materials with organic or mixed character. Stabilisation/solidification (S/S) and advanced oxidation (AOP) processes have been carried out in order to treat both foundry sludge and olive mill waste. Analysis of ecotoxicity, total organic carbon, COD and phenol index have been evaluated in the untreated waste and end‐products. The results of the treated samples allow obtaining the best formulations in both processes. The best formulations in the immobilisation process have been obtained with Portland cement and black carbon, activated carbon or foundry sand ashes. In the AOP process, ozone concentrations above 35 mg/l and reaction times equal to 120 minutes have been the optimal variables. The relationships between the organic parameters and the ecotoxicity of the samples have been studied in this paper. Furthermore, the global organic parameters have been studied in relation to the phenolic compounds. Lineal and logarithmic expressions have been obtained between the total organic carbon and phenol index and the ecotoxicity of the samples related to the organic parameters, respectively. Ecotoxicity of the samples with Vibrio fischeri is recommended as a very promising biotest for the study of the characterisation and the evaluation of the treatment of organic and mixed character waste and total organic carbon is recommended as global organic parameter in the treatment of foundry sludge.
Trigonocephaly in Muenke syndrome
Authors: van der Meulen Jacques , van den Ouweland Ans , Hoogeboom Jeannette 
Published: October 2006

AbstractSaethre‐Chotzen syndrome is caused by mutations in the TWIST gene on chromosome 7p21.2. However, Muenke et al. [(1997); Am J Hum Genet 91: 555–564] described a new subgroup carrying the Pro250Arg mutation in the fibroblast growth factor receptor (FGFR) 3 gene on chromosome 4p16. Uni or bicoronal synostosis appears to be the main clinical finding in both syndromes. We observed trigonocephaly as a new manifestation in Muenke syndrome. As a consequence we advise to routinely perform mutation analysis of the FGFR1, 2, and 3 genes in children with non‐syndromic trigonocephaly. © 2006 Wiley‐Liss, Inc.
Associated malformations in congenital diaphragmatic hernia cases in the last 15 years in a tertiary referral institute
Authors: Harmath Ágnes , Hajdú Júlia , Csaba Ákos , Hauzman Erik , Pete Barbara , Görbe Éva , Beke Anna , Papp Zoltán 
Published: October 2006

AbstractThis is a review of cases of perinatally diagnosed congenital diaphragmatic hernia (CDH) with associated malformations with regard to time of diagnosis, side of hernia, associated malformations, and outcome. The authors analyzed the data of CDH cases with associated malformations from records of the I. Department of Obstetrics and Gynecology, Semmelweis University Faculty of Medicine, Budapest, between July 1, 1990 and June 30, 2005. The observed period was analyzed in two parts. The pre‐ and postnatal examinations verified CDH in 100 cases, 71% of which were associated with other malformations. In 52% (37/71) CDH was diagnosed before the 24th week of gestation. The rate of early diagnosed cases doubled in the second period. Ten percent (7/71) of cases were verified postnatally. Between 1990 and 1997, the percentage of right‐sided hernia was 6% (2/34) while in the second period it was 19% (7/37). The association with cardiovascular, chest, and craniofacial anomalies doubled in the second period, while association of central nervous system anomalies halved. Chromosome anomalies were verified in four cases. Pregnancy was terminated in 53% (34/64) and 13% (4/30) of newborn infants survived the perinatal period. Intrauterine or intrapartum death occurred in 8% (5/64) of cases. The prevalence of cardiovascular, pulmonary, and craniofacial anomalies doubled, while that of central nervous system malformations decreased. The prevalence of other associated malformations has not changed significantly between the two periods. The improvement of technical facilities and accumulated experience make it possible to identify a higher number of associated malformations before the 24th week of gestation. © 2006 Wiley‐Liss, Inc.
Atypical cases of Angelman syndrome
Authors: Lawson‐Yuen Amy , Wu Bai‐Lin , Lip Va , Sahoo Trilochan , Kimonis Virginia 
Published: October 2006

AbstractAngelman syndrome (AS) is a profound disorder notable for mental retardation and severe language deficits that results from lack of function of the maternally inherited copy of the UBE3A gene. Chromosome deletions of 15q11q13, paternal uniparental disomy (UPD), UBE3A gene mutations, and imprinting center defects are all commonly recognized mechanisms that disrupt the function of the maternal copy of the UBE3A gene. We report here two patients with different atypical etiologies of AS. The first patient is a 3‐year‐old boy with global developmental delay, severe speech deficits, seizures, and very happy disposition. Southern blot analysis for the maternal and paternal chromosome 15 methylation products showed a mosaic methylation pattern, suggesting an imprinting center defect. The second patient is a 4½‐year‐old boy with global developmental delay, no expressive language, microcephaly, seizures, and ataxic gait. Array‐based comparative genomic hybridization (CGH) demonstrated a loss in copy number for two overlapping clones encompassing the UBE3A gene, indicating a partial deletion within UBE3A. His mother, who was adopted, had an identical pattern, suggesting that her deletion was probably on her paternally imprinted allele. These patients illustrate the expanding spectrum of molecular findings in AS, reinforce the need to maintain suspicion when clinical features suggest AS but initial testing is normal, and show the power of CGH as a tool to uncover partial UBE3A deletions. © 2006 Wiley‐Liss, Inc.
Daughter and her mildly affected father with Keipert syndrome
Authors: Dumic Miroslav , Kokic Durda Dovzak , Matic Toni , Potocki Kristina 
Published: October 2006

AbstractA 10‐year‐old girl with characteristic features of Keipert syndrome (broad terminal phalanges, especially of the thumb and hallux, sensorineural deafness, unusual facial features, large head circumference, maxillary hypoplasia, hoarse voice) and her mildly affected father (broad terminal phalanges, especially of the thumb and hallux, large head circumference, maxillary hypoplasia, and hoarse voice) are presented. The girl is the first reported female with this rare syndrome to date, and the fact that she probably inherited the disease from her father suggests an autosomal dominant pattern of inheritance. © 2006 Wiley‐Liss, Inc.
Psychopathology in the Lujan–Fryns syndrome: Report of two patients and review
Authors: Lerma‐Carrillo Ivan , Molina Juan D. , Cuevas‐Duran Teresa , Julve‐Correcher Carmen , Espejo‐Saavedra Juan M. , Andrade‐Rosa Cristina , Lopez‐Muñoz Francisco 
Published: October 2006

AbstractWe report on two new patients, the propositus and his maternal uncle, with Lujan–Fryns syndrome (LFS). One presented with mild mental retardation and both patient had Marfanoid habitus and similar craniofacial anomalies (they had a long and narrow face, small mandible, high‐arched palate, and hypernasal voice) as previously reported by Lujan et al. in 1984 and Fryns and Buttiens in 1987. One of our patients had agenesis of the corpus callosum as described by Lujan. The second patient had an ascending aortic aneurysm like the patient described by Wittine et al. 1999. Both patients showed similar behavior and psychiatric disorders. In addition, we reviewed the literature for the presence of psychopathology in LFS. After studying the 32 published cases and the 2 described in this article, we found that more than 90% of the patients present with some type of psychopathology, the most frequent being an autistic‐like disorder. In our opinion, the agenesis of the corpus callosum (complete or partial) and ascending aorta aneurysm are manifestations of LFS, and thus brain MRI and echocardiogram should be part of the routine evaluation. Additionally, the high prevalence of psychopathological alterations in these patients suggests the need for psychiatric evaluation at the time of diagnosis. © 2006 Wiley‐Liss, Inc.
X‐chromosome inactivation patterns in females with Prader–Willi syndrome
Authors: Butler Merlin G. , Theodoro Mariana F. , Bittel Douglas C. , Kuipers Paul J. , Driscoll Daniel J. , Talebizadeh Zohreh 
Published: October 2006

AbstractPrader–Willi syndrome (PWS) is a complex neurodevelopmental disorder caused by loss of paternally expressed genes from the 15q11‐q13 region generally due to a paternally‐derived deletion of the 15q11‐q13 region or maternal disomy 15 (UPD). Maternal disomy 15 is usually caused by maternal meiosis I non‐disjunction associated with advanced maternal age and after fertilization with a normal sperm leading to trisomy 15, a lethal condition unless trisomy rescue occurs with loss of the paternal chromosome 15. To further characterize the pathogenesis of maternal disomy 15 process in PWS, the status of X‐chromosome inactivation was calculated to determine whether non‐random skewing of X‐inactivation is present indicating a small pool of early embryonic cells. We studied X‐chromosome inactivation in 25 females with PWS‐UPD, 35 with PWS‐deletion, and 50 controls (with similar means, medians, and age ranges) using the polymorphic androgen receptor (AR) gene assay. A significant positive correlation (r = 0.5, P = 0.01) was seen between X‐chromosome inactivation and age for only the UPD group. Furthermore, a significantly increased level (P = 0.02) of extreme X‐inactivation skewness (>90%) was detected in our PWS‐UPD group (24%) compared to controls (4%). This observation could indicate that trisomy 15 occurred at conceptus with trisomy rescue in early pregnancy leading to extreme skewness in several PWS‐UPD subjects. Extreme X‐inactivation skewness may also lead to additional risks for X‐linked recessive disorders in PWS females with UPD and extreme X‐chromosome skewness. © 2006 Wiley‐Liss, Inc.
Stereospecific and Stereodivergent Construction of Tertiary and Quaternary Carbon Centers through Switchable Directed/Nondirected Allylic Substitution
Authors: Breit Bernhard , Demel Peter , Grauer Daniel , Studte Christopher 
Published: October 2006

AbstractThis study introduces the ortho‐diphenylphosphanylbenzoate (o‐DPPB)/o‐DPPB oxide system as a switchable directing/nondirecting leaving group in a copper‐mediated allylic substitution with Grignard and organozinc reagents. With this system, the regioselective, stereospecific, and stereodivergent construction of quaternary as well as tertiary carbon centers is possible in a reliable and predictable fashion. Starting from one substrate enantiomer, both optical antipodes of the substitution products are readily available. Hence, this methodology features reversed polarity in comparison to established enolate alkylation chemistry and may be an interesting alternative, particularly for the construction of quaternary stereogenic carbon centers.
Comparative Theoretical Study of N‐Heterocyclic Carbenes and Other Ligands Bound to AuI
Authors: Pyykkö Pekka , Runeberg Nino 
Published: October 2006

AbstractThe bonding strength of N‐heterocyclic carbene (NHC) ligands to a neutral AuCl test moiety are compared to that of several phosphanes and other ligands. Of the ligands studied, the NHCs clearly form the strongest bonds to AuCl. A simplified triangular CN2 model is also introduced for the NHCs.
Integrating Functional Knowledge during Sample Clustering for Microarray Data using Unsupervised Decision Trees
Authors: Redestig Henning , Repsilber Dirk , Sohler Florian , Selbig Joachim 
Published: October 2006

AbstractClustering of microarray gene expression data is performed routinely, for genes as well as for samples. Clustering of genes can exhibit functional relationships between genes; clustering of samples on the other hand is important for finding e.g. disease subtypes, relevant patient groups for stratification or related treatments. Usually this is done by first filtering the genes for high‐variance under the assumption that they carry most of the information needed for separating different sample groups. If this assumption is violated, important groupings in the data might be lost. Furthermore, classical clustering methods do not facilitate the biological interpretation of the results. Therefore, we propose to methodologically integrate the clustering algorithm with prior biological information. This is different from other approaches as knowledge about classes of genes can be directly used to ease the interpretation of the results and possibly boost clustering performance. Our approach computes dendrograms that resemble decision trees with gene classes used to split the data at each node which can help to find biologically meaningful differences between the sample groups. We have tested the proposed method both on simulated and real data and conclude its usefulness as a complementary method, especially when assumptions of few differentially expressed genes along with an informative mapping of genes to different classes are met. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Outcome in the real‐world of coronary high‐risk intervention with drug‐eluting stents (ORCHID)—A single‐center study comparing Cypher™ sirolimus‐eluting with Taxus™ paclitaxel‐eluting stents
Authors: Kumar S. , Suresh V. , Prendergast B.D. , Brooks N.H. , Wicks P. , Levy R.D. , Ray S.G. , Bennett D.H. , Lee H.S. 
Published: October 2006

AbstractObjective: We present real world experience from a single center registry comparing the 6‐month outcome of percutaneous coronary intervention (PCI) in unselected high‐risk individuals using either sirolimus‐eluting (SES) or paclitaxel‐eluting stents (PES). Methods/Results: We compared clinical outcome at 6 months follow‐up in two cohorts of 156 consecutive patients(total n = 312) who underwent SES (June 2002–Februrary 2003) and PES(march 2003–July 2003) implantation. The primary endpoint was a composite of major adverse cardiac events (MACE). Baseline clinical characteristics were well matched. The 6‐month target vessel revascularization (TVR) rates were 1.9% (SES) and 2.6% (PES) and MACE rates were similar in the two groups (SES 4.5% vs. PES 3.2%, P = NS). In the PES group, intervention for multivessel disease, bifurcation lesions and in small vessels was more common, and for in‐stent restenosis less common, reflecting the impact of drug eluting stents on indications for PCI. The incidence of sub‐acute stent thrombosis, related to inadequate antiplatelet therapy in 3 of the 6 cases, was 0.95% with no difference between the two groups. Conclusion: This study confirms the safety and efficacy of SES and PES in unselected high risk patients undergoing PCI. Clinical outcomes of both stents are equivalent at 6 months with low rates of MACE and TVR. These data provide important complementary information to forthcoming randomized studies. © 2006 Wiley‐Liss., Inc.
KNd(MoO4)2: A New Incommensurate Modulated Structure in the Scheelite Family.
Authors: Morozov Vladimir A. , Arakcheeva Alla V. , Chapuis Gervais , Guiblin Nicolas , Rossell Marta D. , Van Tendeloo Gustaaf 
Published: October 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Indides Sc6Co2.18In0.82, Sc10Ni9In19.44 and ScCu4In — Synthesis, Structure, and Crystal Chemistry.
Authors: Zaremba Roman I. , Kalychak Yaroslav M. , Rodewald Ute Ch. , Poettgen Rainer , Zaremba Vasyl' I. 
Published: October 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.