bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrogeochemical processes as a conditioner of freshwater lenses associated with coastal deposits
Authors: Julieta Galliari , Álvarez María del Pilar , Carolina Tanjal , Guido Borzi , Eleonora Carol 
Published: April 2024

AbstractThe aim of this work was to study the processes and factors conditioning the hydrochemistry of freshwater lenses associated with Holocene coastal deposits in an area of the Argentinean Atlantic coast. For this purpose, geomorphological units were mapped and a shallow groundwater monitoring network was established, including pre‐existing boreholes and shallow exploration wells. During the construction of the shallow exploration wells, sediment samples were extracted to determine the texture and mineralogical characteristics. Four samplings were carried out to measure in situ physicochemical parameters and to determine majority ions in the water. The chemical data were analysed considering the associated geomorphology, lithology, water balance and hydrodynamics. The geomorphological and lithological characteristics are the combined factors that favour the preferential rainwater recharge processes. Geoforms with greater topography and extension (continental and coastal dunes) tend to store freshwater lenses, while those with lower topography and little areal extension (sand sheets and beach ridges) have very thin lenses and tend to become salinized. Climate and local water balance are factor that determines that groundwater recharge occurs preferentially in winter. This causes increases in groundwater levels and a decrease in the groundwater EC. On the other hand, mineralogy is a factor that conditions the geochemical processes associated with the water–sediment interaction. Within the main geochemical processes, the dissolution and/or mineral weathering, the dissolution of CO2(g)and ion exchange determine the presence of different hydrochemical facies, where Ca‐HCO3facies dominates in elevated geoforms, while Na‐Cl in lower ones. The results obtained in this work have provided an understanding of the factors and processes that condition groundwater chemistry in coastal deposits, being of vital importance for the management of water resources.
A sustainable glycolipid hydrotrope‐solubilizer for cleansers and detergents
Authors: Chirac Marie‐Françoise , Cambos Sophie , Guilbot Jérôme , Nawrocki Corinne , Marchand Régis , Roso Alicia 
Published: April 2024

AbstractAlkyl polyglycosides (APGs), based on renewable glucose and fatty alcohols, are recognized for their performance and biodegradability. Hydrotropic/solubilizing effect properties have already been identified on short‐chain variants such as hexyl and ethylhexyl, but these ingredients were not fully bio‐based. This study investigated the hydrotropic/solubilizing properties of eco‐designed 100% bio‐based heptyl glucoside, under various conditions, compared to industrial and personal care benchmarks and other short chain APGs. Foaming power was firstly evaluated at different temperatures with two static methods. Hydrotropic performance was assessed with a commonly used surfactant in the presence of high electrolyte, acid and alkali concentrations. Further trials were done using ethoxylated rapeseed oil as an oil lubricant model in electrolyte‐charged aqueous solution. The solubilizing effect of hydrophobic additives such as fragrances, essential oils and vitamin E was quantified. Finally, effects on formulation preservation were screened with two natural personal care preservatives. Heptyl glucoside was found to be an effective and versatile hydrotrope for industrial applications, with additional intrinsic lubrication properties. It was also revealed as an efficient solubilizer for personal care products with the additional benefit of reducing the preservative dosage required in natural formulations. Its unusual non‐foaming nature, while not disrupting the foaming capacity of surfactants, makes it suitable for all types of cleansers. The calculated carbon footprint has a low value, making heptyl glucoside a valuable ingredient combining both performance and low environmental impact.
Allosteric modulation of fluorescence revealed by hydrogen bond dynamics in a genetically encoded maltose biosensor
Authors: Berksoz Melike , Atilgan Canan 
Published: April 2024

AbstractGenetically encoded fluorescent biosensors (GEFBs) proved to be reliable tracers for many metabolites and cellular processes. In the simplest case, a fluorescent protein (FP) is genetically fused to a sensing protein which undergoes a conformational change upon ligand binding. This drives a rearrangement in the chromophore environment and changes the spectral properties of the FP. Structural determinants of successful biosensors are revealed only in hindsight when the crystal structures of both ligand‐bound and ligand‐free forms are available. This makes the development of new biosensors for desired analytes a long trial‐and‐error process. In the current study, we conducted μs‐long all atom molecular dynamics (MD) simulations of a maltose biosensor in both the apo (dark) and holo (bright) forms. We performed detailed hydrogen bond occupancy analyses to shed light on the mechanism of ligand induced conformational change in the sensor protein and its allosteric effect on the chromophore environment. We find that two strong indicators for distinguishing bright and dark states of biosensors are due to substantial changes in hydrogen bond dynamics in the system and solvent accessibility of the chromophore.
Maximal Quantified Precondition Synthesis for Linear Array Loops
Authors: Sumanth Prabhu S , Fedyukovich Grigory , D’Souza Deepak 
Published: April 2024

AbstractPrecondition inference is an important problem with many applications in verification and testing. Finding preconditions can be tricky as programs often have loops and arrays, which necessitates finding quantified inductive invariants. However, existing techniques have limitations in finding such invariants, especially when preconditions are missing. Further, maximal (or weakest) preconditions are often required to maximize the usefulness of preconditions. So the inferred inductive invariants have to be adequately weak. To address these challenges, we present an approach for maximal quantified precondition inference using aninfer-check-weakenframework. Preconditions and inductive invariants are inferred by a novel technique calledrange abduction, and then checked for maximality and weakened if required. Range abduction attempts to propagate the given quantified postcondition backwards and then strengthen or weaken it as needed to establish inductiveness. Weakening is done in a syntax-guided fashion. Our evaluation performed on a set of public benchmarks demonstrates that the technique significantly outperforms existing techniques in finding maximal preconditions and inductive invariants.
Education for Future Skills Development: Cognitive, Collaborative and Ethical Skills
Authors: Păunescu Carmen , McDonnell-Naughton Mary 
Published: April 2024

AbstractThis chapter focuses on the cognitive, collaborative, and ethical skills that the future higher education student will need to acquire to meet the skills wanted for the future. It explores learning methods that may be of interest in this field. The encouragement of reflective practice will encompass the competencies that will help to make sense of new concepts and policies underpinning good critical thinking. This will lend itself to the student gaining a competency level to drive efficient and effective decision making, thus ultimately contributing to society. The students themselves, through a thirst for knowledge and skills, will become self-directed learners, and learn how to work collaboratively with colleagues, all of which is essential for the Future Skills society. Based on two case studies, the chapter illustrates how the students develop their Future Skills and connect their learning experiences to explore various opportunities, whilst thinking and working in an ethical manner, adhering to a code of practice.
Interdisciplinary Project to Build Teaching Skills: A Pedagogical Approach
Authors: Garbin Mônica Cristina , de Oliveira Edison Trombeta 
Published: April 2024

AbstractThe concept of “competence” includes the knowledge to be acquired, skills and attitudes. It is not enough for the professional to have a lot of knowledge, but it is necessary that he knows how to mobilize his knowledge in solving problems or in creating something innovative. The Interdisciplinary Project (IP) developed by higher education students at Virtual University of São Paulo State—Univesp (Brazil) is guided by Project-Based Learning (PBL) and Human-Centered Design (HCD), in which the pedagogical action is based on the principle of the inseparability of the relationship between theory and practice. In this scenario, students develop at least six essential skills such as: Investigation; Problem Solving; Collaboration; Communication; Professional; and Technological Practice. The aim of this chapter is to correlate the skills proposed in the teacher’s education at Univesp with the Future Skills proposed by Ehlers (2020). As a result, we assess that Univesp is a leader in this area and can train teachers with skills for a better education in the future.
Teaching the Skills Needed for the Future
Authors: Bates Tony 
Published: April 2024

AbstractTechnology is leading to massive changes in the economy, in the way we communicate and relate to each other, and increasingly in the way we learn. Teachers and instructors are faced with a massive challenge of change. There are many opportunities in even the most academic courses to develop intellectual and practical skills that will carry over into work and life activities in a digital age, without corrupting the values or standards of academia. Even in vocational courses, students need opportunities to practice intellectual or conceptual skills such as problem-solving, communication skills, and collaborative learning. The chapter explores the skills that will be needed, and ways in which such skills can be developed. It approaches questions such as how we can ensure that we are developing the kinds of graduates from our courses and programs that are fit for an increasingly volatile, uncertain, complex, and ambiguous future as well as how we can teach or help students develop the skills they will need in the twenty-first century.
The protective effect of vitamin A palmitate eye gel on the ocular surface during general anaesthesia surgery: a randomized controlled trial
Authors: Li Siyuan , Lei Guiyu , Liu Ying , Tian Lei , Jie Ying , Wang Guyan 
Published: April 2024

Abstract
Purpose
To investigate the change in tear production associated with general anesthesia and the protective effect of vitamin A palmitate eye gel on the ocular surface during general anesthesia.

Methods
This double-blind, randomized clinical trial included patients undergoing non-ophthalmic surgery under general anesthesia who randomly received vitamin A palmitate eye gel and taping for one eye (Group A, n = 60) or taping alone for the other eye (Group B, n = 60). Symptom assessment in dry eye (SANDE) score, tear film break-up time (TBUT), corneal fluorescein staining (CFS) score, and Schirmer tear test I (STT-1) were analyzed under a hand-held slit lamp before anesthesia (T0), 0.5 h postoperatively (T1), and 24 h postoperatively (T2).

Results
At 0.5 h postoperatively, an increase in CFS score was observed in both groups (P < 0.05 in Group A and P < 0.01 in Group B), and the participants in Group A had less corneal abrasions than those in Group B. STT-1 significantly increased in Group A (P < 0.05), while it significantly decreased in Group B (P < 0.001). The changes between the two groups were statistically significant (P < 0.001). At 24 h postoperatively, both CFS score and STT-1 almost returned to baseline levels in the two groups. In both groups, the SANDE score and TBUT showed little change at 0.5 h and 24 h postoperatively (all P > 0.05).

Conclusion
Vitamin A palmitate eye gel effectively protected the ocular surface and aqueous supplementation during general anesthesia.

Trial registration
This study was registered in the Chinese Clinical Trial Registry (ChiCTR2100052140) on 20/10/2021.
Was Robert Gibrat right? A test based on the graphical model methodology
Authors: Guerzoni Marco , Riso Luigi , Vivarelli Marco 
Published: April 2024

Abstract
Using both regression analysis and an unsupervised graphical model approach (never applied before to this issue), we confirm the rejection of Gibrat’s Law (stating that a firm’s growth is independent of that firm’s initial size) when our firm-level data are considered over the entire investigated period, while the opposite is true when we allow for market selection; indeed, the growth behavior of the surviving most efficient firms is in line with Gibrat’s Law. This evidence reconciles early and current literature and may have interesting implications in terms of both theoretical research and policy suggestions regarding subsidies to small firms, which do not necessarily grow faster than their larger counterparts.
Key antecedents of maximal levels of aspiration and minimal boundary goals: a structural equation modeling analysis
Authors: Hodis Flaviu A. , Hodis Georgeta M. 
Published: April 2024

AbstractResearch findings indicate that two types of goals, which focus on the lowest (highest) levels of achievement possible in a learning setting, are strong predictors of how well students attain in school. Unfortunately, little is known about how these two goals, termed minimal boundary goals (MBG) and maximal levels of aspiration (MLA) relate to psychological constructs that are theorized to be antecedents of goals. To fill this knowledge gap, this research collected data from 463 secondary-school students and tested a model linking these goals to achievement motives and theory of intelligence. Results revealed that not believing that intelligence is fixed and devoting effort to studying was associated with a strong endorsement of MLA. At the same time, making low/no efforts to study, being afraid of failure, and believing that intelligence is fixed were strong predictors of MBG. These findings advance current knowledge and have important implications for teaching and learning.
Identification of immune-associated biomarker for predicting lung adenocarcinoma: bioinformatics analysis and experiment verification of PTK6
Authors: Xiong Ren-Hui , Yang Shuo-Qi , Li Ji-Wei , Shen Xun-kai , Jin Lu-Ming , Chen Chao-Yang , Yue Yu-Ting , Yu Zhi-Chen , Sun Qing-Yu , Jiang Wen , Jiang Ming-Zheng , Wang Xiao-Yan , Song Shi-Xu , Cao Dai , Ye Hong-li , Zhao Li-Ran , Huang Li-Peng , Bu Liang 
Published: April 2024

Abstract
Background
Abnormal expression of protein tyrosine kinase 6 (PTK6) has been proven to be involved in the development of gynecological tumors. However, its immune-related carcinogenic mechanism in other tumors remains unclear.

Objective
The aim of this study was to identify PTK6 as a novel prognostic biomarker in pan-cancer, especially in lung adenocarcinoma (LUAD), which is correlated with immune infiltration, and to clarify its clinicopathological and prognostic significance.

Methods
The prognostic value and immune relevance of PTK6 were investigated by using bio-informatics in this study. PTK6 expression was validated in vitro experiments (lung cancer cell lines PC9, NCI-H1975, and HCC827; human normal lung epithelial cells BEAS-2B). Western blot (WB) revealed the PTK6 protein expression in lung cancer cell lines. PTK6 expression was inhibited by Tilfrinib. Colony formation and the Cell Counting Kit-8 (CCK-8) assay were used to detect cell proliferation. The wound healing and trans-well were performed to analyze the cell migration capacity. Then flow cytometry was conducted to evaluate the cell apoptosis. Eventually, the relationship between PTK6 and immune checkpoints was examined. WB was used to estimate the PD-L1 expression at different Tilfrinib doses.

Results
PTK6 was an independent predictive factor for LUAD and was substantially expressed in LUAD. Pathological stage was significantly correlated with increased PTK6 expression. In accordance with survival analysis, poor survival rate in LUAD was associated with a high expression level of PTK6. Functional enrichment of the cell cycle and TGF-β signaling pathway was demonstrated by KEGG and GSEA analysis. Moreover, PTK6 expression considerably associated with immune infiltration in LUAD, as determined by immune analysis. Thus, the result of vitro experiments indicated that cell proliferation and migration were inhibited by the elimination of PTK6. Additionally, PTK6 suppression induced cell apoptosis. Obviously, PD-L1 protein expression level up-regulated while PTK6 was suppressed.

Conclusion
PTK6 has predictive value for LUAD prognosis, and could up regulated PD-L1.
Assessing motivation for treatment in eating disorders: psychometric validation of the Italian version of the Autonomous and Controlled Motivation for Treatment Questionnaire (ACMTQ-ITA)
Authors: Tempia Valenta Silvia , Rapezzi Matilde , Marcolini Federica , Speciani Maurizio , Giordani Gabriele , De Panfilis Chiara , De Ronchi Diana , Atti Anna Rita 
Published: April 2024

Abstract
Purpose
Treatment resistance is a significant challenge in addressing eating disorders (EDs). The Autonomous and Controlled Motivation for Treatment Questionnaire (ACMTQ) has been previously validated in ED populations to assess patients’ motivation for treatment. This study aimed to validate the ACMTQ in the Italian language (ACMTQ-ITA) and evaluate its psychometric properties.

Methods
We recruited a clinical sample of adults aged 18 or older, diagnosed with EDs, proficient in the Italian language, and providing written informed consent. Participants with psychiatric comorbidities such as schizophrenia, bipolar disorder, and substance use disorder were excluded from the study. Validity of the ACMTQ-ITA was assessed using reliability analysis with Cronbach’s α and McDonald’s ω estimates, and Confirmatory Factor Analysis (CFA).

Results
Results from the reliability analysis confirmed the internal consistency of the Autonomous Motivation (AM) factor (α = 0.82, ω = 0.82), the Controlled Motivation (CM) factor (α = 0.76, ω = 0.77), and the ACMTQ-ITA overall score (α = 0.79). The CFA confirmed the two-factor solution (i.e., AM and CM) identified in the original validation of the ACMTQ (Comparative Fit Index = 0.92, Akaike Information Criterion = 3427.26, Bayesian Information Criterion = 3486.82; Root Mean Square Error of Approximation = 0.08, Standardized Root Mean Square Residual = 0.09).

Conclusion
The ACMTQ-ITA emerged as a valid and reliable tool for measuring motivation for treatment in individuals with EDs. Its implementation may facilitate the comprehension of treatment motivation, offering valuable clinical insights and implications for health management practices.
Level of evidence: Level V, descriptive studies.
Building an Equity-Centered Ecosystem: University of Utah Health as a Microcosm
Authors: Nguyen Quang-Tuyen , Cabal Victoria , Debbink Michelle , Acosta David , Flattes Valerie J. , Baluchi Donna , Ovuoba Natasha , Cariello Paloma F. , Watts Bart T. , Clouse Erin R. , Nyman Heather , Taylor Eliza , Kemeyou Line , Lucero Julie E. , Washington Judy C. , Figueroa Edgar , Campbell Kendall M. , Barbaar Abdulkhaliq , Ogbeide Stacy A. , Rodríguez José E. 
Published: April 2024

AbstractAcademic medicine, and medicine in general, are less diverse than the general patient population. Family Medicine, while still lagging behind the general population, has the most diversity in leadership and in the specialty in general, and continues to lead in this effort, with 16.7% of chairs identifying as underrepresented in medicine. Historical and current systematic marginalization of Black or African American, Latina/e/o/x, Hispanic or of Spanish Origin (LHS), American Indian/Alaska Native, Native Hawaiian/Pacific Islander, and Southeast Asian individuals has created severe underrepresentation within health sciences professions. Over the last 30 years, the percentage of faculty from these groups has increased from 7 to 9% in allopathic academic medicine, with similar increases in Osteopathic Medicine, Dentistry, and Pharmacy, but all lag behind age-adjusted population means. Traditionally, diversity efforts have focused on increasing pathway programs to address this widening disparity. While pathway programs are a good start, they are only a portion of what is needed to create lasting change in the diversity of the medical profession as well as the career trajectory and success of underrepresented in medicine (URiM) health professionals toward self-actualization and positions of leadership. This article elucidates all parts of an ecosystem necessary to ensure that equity, diversity, and inclusion outcomes can improve.
Policy insights for wind energy from a choice experiment stated preference efficient design in Apulia region (Italy)
Authors: Caporale Diana , De Lucia Caterina , dell’Olio Luigi , Pazienza Pasquale 
Published: April 2024

AbstractThe present work argues that wind energy is either a positive or negative determinant against the risks associated with its use, and aims at: evaluating the incidence of energy risks on the perception of wind energy; analysing the trade-offs between a wind farm installation, land conservation and energy risks; suggesting adequate policy indications for the efficiency of future energy markets. The study compares the results from logit models, which estimate the distribution of the utility coefficients with a Choice Experiment approach using a stated preference efficient design and honesty priming techniques to overcome the hypothetical bias. Main findings indicate a positive attitude for the proposed wind energy scenarios in terms ofAesthetical impact,CO2andBill savings, andCosts, as well as more densely distributed wind farms producing more energy. Installation and maintenance costs and the rate of avian collisions are considered acceptable. From the main findings, useful policy insights assess the efficiency of wind farms projects to reduce costs and energy prices. Simplification of bureaucracy, direct economic benefits for local communities, citizens’ participation, and dissemination of information are key practices for future developments of wind energy markets.
“Darling, You Won’t Believe What Happened at Work Today”: A Diary Study on Sharing Work Events Among Dual-Earner Couples
Authors: Walter Johanna , Haun Verena C. 
Published: April 2024

AbstractAfter work, employees often share their work experiences with their partners, yet the consequences of these work-related conversations remain poorly understood. In this study with dual-earner couples, we investigate the daily consequences of sharing positive and negative work events with a partner regarding both employees’ and their partners’ affect and work-related self-esteem. Throughout a workweek, 73 heterosexual dual-earner couples completed questionnaires after work and at bedtime. Dyadic multilevel analyses showed that sharing positive work events was positively associated with employees’ positive affect but not with partners’ positive affect. Sharing negative work events showed no significant association with the negative affect of either employees or partners. While sharing positive work events was not associated with employees’ self-esteem, it was negatively associated with partners’ self-esteem. Furthermore, sharing negative work events was negatively associated with partners’ self-esteem, but did not affect employees’ self-esteem. Our study extends existing research on work-related conversations, considering self-esteem as an outcome and adopting a dyadic perspective.