bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Usefulness of Doppler Echocardiography for the Evaluation of Hemodynamics in Tetralogy of Fallot: Comparison of the Patients with Pre‐ and Post‐Corrective Surgery and Control Healthy Children
Authors: Watari Tohoru , Awa Shoichi , Hishi Toshio , Akagi Michio , Fong Lin I , Nakamura Gen 
Published: October 2007

AbstractTwodimensional Doppler echocardiographic examinations were performed in 61 patients (39 boys and 22 girls) with tetralogy of Fallot (TOF). The patients were examined at the Department of Pediatrics, University of Tokyo, and at the Department of Pediatrics, Ohta General Hospital, in Koriyama city, Fukushima Prefecture.One hundred and eighteen healthy children (59 boys and 59 girls) were also examined at the Waseda housing complex in Misato city, Saitama Prefecture.By short axis view of aorta, samples were collected from both the right ventricular outflow tract below the pulmonary valve and in the main pulmonary artery. On the other hand, the apex four chamber view was used to collect samples at the right and left atrial outflows.Right ventricular systolic time intervals were measured both at the main pulmonary artery (PA) and at the outflow tract below the pulmonary valve (RVO).The right ventricular systolic pre‐ejection period (PAPEP) and acceleration time (PAACT), measured at the supra‐valvular site, were shorter before surgery as compared to after surgery and normals. The ratio of right ventricular pre‐ejection period to ejection time (PAPEP/ET) and the ratio of acceleration time to ejection time (PAACT/ET) were both significantly lower before surgery compared to after surgery and controls.The mean main pulmonary artery peak velocity before surgery was 369 cm/sec and the peak pressure gradient calculated with the modified Bernoulli formula was 55 mmHg.Before surgery, peak velocity of right ventricular rapid filling (R‐wave) was low, while peak velocity of atrial contraction (A‐wave) was high. After surgery, however, R‐wave increased and A‐wave decreased in velocity. The peak velocity of left ventricular filling R‐wave was also low before surgery and increased after surgery, while peak velocity of left atrial contraction A‐wave was increased before surgery and decreased to almost normal values after surgery. The left ventricular A/R ratio before surgery was also high as a result of low R‐wave velocity. The measured time interval between aortic valve closing sound and left ventricular rapid filling wave (IIA‐R time), and the measured time interval between pulmo nary valve closing sound and ventricular filling wave (IIP‐R time) were both longer before surgery than those after surgery and controls. Consequently, the measured time intervals between rapid ventricular filling flow wave and atrial contraction wave (R‐A time) for both right and left atrial were shorter before surgery than after surgery and controls. A new method for estimation of pulmonary‐to‐systemic blood flow ratio (Qp/Qs) was successfully applied to TOF, and a good correlation was obtained between Qp/Qs determined by this method and that by the Fick method.
Chest Pain in Pediatric Patients
Authors: Fukushige Junichiro , Tsuchihashi Keiko , Harada Tatsuo , Ueda Kohji 
Published: October 2007

AbstractOne hundred and twenty‐three patients (72 males and 51 females) with the chief complaint of chest pain, seen at our department during the five‐year period from January 1982 to December 1986, were studied regarding their past medical history, physical findings, results of diagnostic tests, and prognosis. The ages of the subjects ranged from 3 to 16 years (mean 11.7 years) in boys and 3 to 20 years (mean 10.9 years) in girls, constituting 0.54% of the total number of the mean annual outpatients. Of these 123, 80 patients (65%) had chest pain lasting over one month, and 91 patients (74%) had a short time of duration of pain which improved within a few seconds to five minutes. In nine (7%) of the 123 patients, the pain was considered to be related to cardiovascular lesions and in 82 patients (67%) as being idiopathic chest pain. Chest pain in children is rarely due to serious primary cardiovascular diseases.
Familial Insulin‐Resistant Diabetes Mellitus without Acanthosis Nigricans or Androgenization
Authors: Takumi Toru , Kodama Sochi , Tsubota Toru , Nishio Hisahide , Takahashi Toshikazu , Yokono Koichi , Matsuo Tamotsu 
Published: October 2007

AbstractA 12‐year‐old Japanese girl and her mother showed insulin‐resistant diabetes mellitus which was confmed by the response to an oral glucose load in both patients and by the small decrease in blood glucose after intravenous insulin in the daughter. Anti‐insulin antibodies and anti‐insulin‐receptor antibodies were not detected in either patient. The circulating erythrocytes were found to have reduced insulin binding capacity, which, to judge from ID50, was probably caused by decreased binding affhty of insulin receptors.The patients did not have acanthosis nigricans or signs of androgenization such as hirsutism, dysmenorrhea or polycystic ovaries. Endocrinological studies in the daughter showed elevated basal serum levels of luteinizing hormone (LH), dehydroepiandrosterone, testos terone and estrone, and an exaggerated LH response to LH‐RH. It is possible that hyper‐insulinemia caused by insulin resistance contributed to the increased secretion of LH and androgens, but it was unclear why signs of androgenization were absent in spite of increased secretion of LH and androgens.
Gonadotropin Deficiency as a Significant Association of Complex Glycerol Kinase Deficiency: A Case Report with Cytogenetic and Molecular‐Genetic Studies
Authors: Yoshimoto Masaaki , Baba Tsuneyoshi , Fukuda Shinpei , Matsumoto Tadashi , Hayashi Sawako , Niikawa Norio , Matsuda Lchiro , Tsuji Yoshiro 
Published: October 2007

AbstractA 6‐year‐old Japanese male patient with complex glycerol kinase deficiency (CGKD) is described. In addition to glycerol kinase deficiency, congenital adrenal hypoplasia, Duchenne muscular dystrophy, mental retardation and short stature, gonadotropin deficiency (GTD) was confirmed. The continuous stimulation of LHRH recovered the increment of serum LH and FSH values. Cytogenetic and molecular‐genetic studies revealed a deletion in the Xp21 region which may involve many genes. Although a few cases of CGKD associated with GTD and/or cryptorchidism have been described, the cause of GTD has not been mentioned in the literature. The simultaneous occurrence of CGKD and GTD in these patients including ours may not be coincidental, but suggests the existence of a certain gene in the Xp21 region which may affect the development of hypothalamic LHRH secretory function. Therefore detailed and repeated evaluations of gonadotropin secretion are necessary in patients with CGKD.
Combined Esophageal and Pyloric Atresia without Tracheoesophageal Fistula in Down's Syndrome
Authors: Matsuo Yasutaka , Nukina Sadayuki , Hasegawa Kou , Yoshida Naoko , Doi Yasuo , Sawada Tadashi , Tomioka Megumi 
Published: October 2007

AbstractThis is the first report of a newborn infant with Down's syndrome associated with combined congenital pyloric and esophageal atresias without a tracheoesophageal fistula (Gross A type).A mother was noted to have marked abdominal distension and hydramios was suspected at 28 weeks gestation. Ultrasonographic findings of her abdomen demonstrated that the fetus was suspected of having congenital duodenal and esophageal atresia, from the large doubleecho‐free spaces occupying the greater part of the abdomen. Chromosome analysis of the amniotic fluid showed a karyotype of 21 trisomy. The newborn baby had clinical characteristics of Down's syndrome and severe abdominal distension after birth.At 19 days after birth, autopsy revealed pyloric and esophageal atresias without trache oesophageal fistula.We conclude that ultrasonographic examination is useful for the prenatal diagnosis of a patient with gastrointestinal obstruction combined with esophageal atresias, without trache oesophageal fistula.
Histopathological Study of the Biopsied Muscles from Juvenile Patients with Congenital Myotonic Dystrophy
Authors: Wakai Shuji , Kameda Keiji , Okabe Minoru , Nagaoka Masato , Minami Ryoji , Tachi Nobutada 
Published: October 2007

AbstractHistopathology and histochemistry were studied in biopsied muscles from eight patients with the congenital form of myotonic dystrophy (congenital MyD) and one patient with the adult form (adult MyD). In the muscle pathology of the four patients aged between 5 and 11 years with congenital MyD, there was no immaturity of the fibers and the histological alterations were minimal. The pathological findings of the adult patient with congenital MyD resembled those of adult MyD. The immature condition of the musculature observed during the early infantile period, therefore, may once improve with motor development during childhood and, after that, the muscle fibers may degenerate in a similar manner to that seen in adult MyD.Two patients with marked talipes equinovarus displayed grouped atrophy. Small angular fibers and pyknotic nuclear clumps were observed in five patients. These findings suggest that some neurogenic factor might be involved in the muscular changes in this disorder.
Scanning Electron Microscopic Studies on Streptococcal Aerosol Infection
Authors: Yoshinaga Masao , Hokonohara Masashi , Haraguchi Tsutomu , Inoue Hiroyuki , Miyata Koichiro 
Published: October 2007

AbstractThe initial focus of streptococcal invasion and histological changes of rabbit tonsils infected by aerosolinduced streptococci was investigated by scanning electron microscopic studies of the free and fractured surface of the tonsils.Group A type 12 streptococci were suspended in saline at a concentration of 108 to 109 colony forming units per ml. Rabbits were exposed to the aerosolized suspension for about 120 minutes and sacrificed within 48 hours after the exposure.The tonsilar epithelium was organized in two different types. The micro‐pores of the crypts were divided into three types. Some interesting findings were observed in the micropores covered by cobblestone‐like cells with micro‐villi or cillia (the third type). That is, the micropore had a trace left by something that had passed. Also, the infiltrating cells appeared numerously after the exposure and continuously from the parenchyma of the tonsils.These data suggested that the third type micropores play an important role in the initial focus of invasion and in the defense or immunological process.
Effects of Maternal Phenylalanine or Tyrosine Hydroxylase Inhibition on Postnatal Maturation of Catecholamine and Amino Acid Metabolism in Rats
Authors: Sato Tamotsu , Imura Eiichi , Murata Akisato , Minami Satoshi , Okabe Takashi , Ohno Ichiroh 
Published: October 2007

AbstractEffects of the inhibition of maternal phenylalanine (Phe) or tyrosine (Tyr) hydroxylase on the postnatal maturation of catecholamine, thyroxine and amino acid metabolisms were examined in young rats. The intraperitoneal injections of 100 mg/kg p‐chlorophenylalanine three times during the second gestational week together with 0.2% Phe solution as drinking water produced marked reduction in birth weight, body weight gain, brain weight, cerebral Tyr hydroxylase activity, adrenal epinephrine, renal norepinephrine and free amino acids in plasma and brain as well as delayed maturation of thermoregulation in the offspring. In contrast, the administration of 100 mg/kg α‐methyl‐p‐tyrosine with 0.2% Tyr supplementation did not affect general growth, but only decreased cerebral Tyr hydroxylase and serum thyroxine level, while cerebral dopamine was increased. These results indicate that maternal Phe hydroxylase inhibition induces more severe growth failure including catecholamine and amino acid metabolism than Try hydroxylase inhibition in postnatal development.
Benign Childhood Epilepsy with Centro‐Temporal Spikes: Evolution of Seizure Types
Authors: Ishikawa Tatsuya , Nakazato Mikiko , Awaya Atsuko , Kanayarna Manabu 
Published: October 2007

AbstractEvolution of the seizure types according to age in 20 outpatients with benign childhood epilepsy with centro‐temporal spikes (BECT) was studied. BECT satisfied the following criteria: 1) normal intelligence, 2) central and/or mid‐temporal spikes with normal background activities on the interictal EEG recordings, and 3) partial and/or generalized seizures in sleep. The patients were divided into two groups according to the clinical course; P (n = 10): patients with only (n = 6) or predominantly (n = 4) partial seizures, G (n = 10): those with only (n = 7) or predominantly (n = 3) generalized seizures. No difference in the age at onset was noted between the two groups. There were also no indications that the seizures tend to generalize at a younger age or remain partial at an older age. Therefore, age is not important in the evolution of partial to generalized seizures in BECT.
Ultrasonographic Findings in Periventricular Leukomalacia in the Newborn: Two Cases Associated with Early Onset Group B Streptococcal Sepsis
Authors: Ogino Takatoshi , Kanda Yasushi , Kawakita Akira , Yamagrchi Nobuyuki , Futamura Masahide , Goto Haruo 
Published: October 2007

AbstractThe ultrasonographic findings in periventricular leukomalacia (PVL) in the newborn are described, and the relationship between PVL and group B streptococcal (GBS) infection is discussed. Two newborn infants (one preterm and one term) suffered from early onset GBS sepsis with shock; they showed increased echogenicity in the periventricular regions; one of them developed cystic changes. These findings might be due to decreased perfusion of the periventricular end arterial zone. It is suggested that serial ultrasonography should be performed in neonates who suffer hypoxic‐ischemic brain injury.
Outcome of Therapy of Hereditary Tyrosinemia
Authors: Halvorsen Sverre , Kvittingen Eli‐Anne , Flatmark Audun 
Published: October 2007

AbstractWe diagnosed 21 patients with hereditary tyrosinemia in Norway; 14 of them had the diagnosis confirmed by enzyme studies. Five died in infancy before dietary treatment was introduced. Six developed hepatoma, between the ages of 3 ½‐ 20 years, three of them while on dietary treatment. Three died from causes other than hepatoma. Of the seven still alive at the time of writing, two received liver transplants, and one a kidney transplant, three are receiving dietary treatment and one is being managed without a special diet.Dietary treatment may be life‐saving in acute cases. It improves the general condition in the chronic forms, improves tubular dysfunction and growth and may postpone develop ment of hepatoma. Liver transplantation is the only curative treatment, but difficulty remains in deciding the optimum time for transplantation; it should ideally be performed before hepatoma develops.
Influence of Fatty Diet on Neonatal Jaundice in Breast‐Fed Infants
Authors: Amato M. , Berthet G. , Muralt G. Von 
Published: October 2007

AbstractWe studied milk samples from mothers of breast‐fed full‐term infants with “physiologic jaundice” and compared them with milk samples of healthy breast‐fed control babies to investigate if the percentage of cream or “Creamatocrit” could be related to neonatal hyper‐bilirubinemia. The results of this study confirm our hypothesis: a statistically significant difference was found between the two groups of patients (χ2 ‐test, p < 0.002).
Ring Chromosome 7: Report of a Case
Authors: Kohyama Jun , Watanabe Seiichi , Nakajima Masaki , Suzumura Hirosi , Ishikawa Toshihiko , Ishikawa Kiyoto , Saito Fumiko , Fukuda Chikao. 
Published: October 2007

AbstractA 5‐month‐old girl with a ring chromosome 7 [46, XX, r(7) (p22q36)I is presented. She was the fifth and youngest patient with this chromosomal anomaly, and the first instance whose chromosomal breakpoints were determined by high resolution banding analysis, Numerous café‐au‐lait‐like pigmentation spots and hypoplasia of the thenar creases were observed.
Phosphorus Deficiency Syndrome in Two Very Low Birthweight Infants
Authors: Tsukahara Hirokazu , Sakaguchi Tadahiko , Mitsuyoshi Izuru , Fukuhara Hitoo , Hayashi Shuhei , Nakamura Katsuji 
Published: October 2007

AbstractBiochemical and radiographic abnormalities linked with phosphorus deficiency syndrome (PDS) developed in two very low birthweight (VLBW) infants fed exclusively with human milk. By increasing phosphorus (P) and calcium (Ca) intakes with the introduction of a specialized premature formula, osteopenia or rickets, as well as hypophosphatemia, hypo‐phosphaturia and increased serum alkaline phosphatase levels improved in both patients. We speculated that all VLBW infants who are being fed exclusively with human milk should be monitored for PDS and that if PDS develops, supplementation of human milk with both P and Ca appears to be necessary for its treatment.
Bone Evaluation by Microdensitometry in Patients with Juvenile Reumatoid Arthritis
Authors: Takei Syuji , Hiwatari Mihoko , Imanaka Hiroyuki , Hokonohara Masashi , Miyata Koichiro 
Published: October 2007

AbstractTo evaluate the hand bones of patients with juvenile rheumatoid arthritis (JRA) objectively, 30 patients with JRA were examined by microdensitometric analysis (MD). The results were as follows: 1) Among the nine indices of MD, %σGS/D, reflecting the bone mineral content, correlated well with the stage of JRA determined by roentgenological findings of the hand bones. 2) %σGS/D showed remarkable improvement after the remission of JRA. 3) Rheumatoid factor (RF) positive JRA showed statistically low %σGS/D compared with RF negative JRA, and kept a low %σGS/D for a long period from the onset in contrast to RF negative JRA. 4) %σGS/D in the patients with JRA treated with steroid decreased more rapidly according to the dosage of steroid than in the patients with SLE. Based on these results it is suggested that MD seems to be useful in evaluating the bone objectively, and not only steroid but also RF seems to be a factor leading to bone destruction in patients with JRA.
Mothers' Attitudes towards Children's Three‐Year Health Examination
Authors: Nishi Motoi , Akatsuka Tomohiro , Inoue Yuko , Kamasaki Hotaka , Kamibayashi Yoshihito , Nakamachi Satoko , Hamaoka Shuji , Hayashi Eri , Miyake Hirotsugu , Takasugi Nobuo , Sato Yasumasa , Hanai Junji , Nagasaka Mina , Saeki Yoshito , Takeda Takeo 
Published: October 2007

AbstractIn the two health centers of Sapporo City, 112 mothers whose children participated in a three‐year health examination, and 107 mothers whose children did not, were interviewed about their children's health.More time and expense were necessary for the latter group to come to the health centers. Some children did not attend because of apparent indifference of their mothers to health matters. In both groups there was a tendency for attendance for vaccinations and health examinations to decrease as the child's age advanced, especially after four months.For the purpose of increasing the number of children who receive a three‐year health examination, provision of appointments extending over several days with extra examinations in places outside the usual health centers, in addition to making available detailed information on the examination, seem to be effective.A considerable proportion of mothers accepted re‐screening for neuroblastoma, for which most could afford 1,000 yen.
Virological, Serological and Molecular Analysis of a Case with Congenital Cytomegalovirus Infection
Authors: Eizuru Yoshito , Takahashi Hirohiko , Ueno Ichiro , Minamishima Yoichi 
Published: October 2007

AbstractCytomegalovirus (CMV) was isolated concurrently from an infant and her mother on the 2nd day after delivery. Restriction endonuclease cleavage analysis of viral DNAs revealed that these two CMVs were identical. Sera from the infant and mother were both positive for IgM specific to CMV and antibody against early antigen (EA). Thus, virological, serological and molecular analysis indicated the transmission of CMV from a mother to her fetus in utero.
Isolated Tricuspid Valve Endocarditis in a Child with a Normal Heart
Authors: Matsuoka Yuji , Yamami Nobuo , Nishiguchi Toshihiro , Hayakawa Kunio 
Published: October 2007

AbstractInfective endocarditis localized in the tricuspid valve was observed in a previously completely healthy 10‐yeardd male. The pathogen was identified as Staphylococcus uureus. Twodimensional and Doppler echocardiography revealed rupture of the chordae tendineae and prolapse of the tricuspid septal leaflet with tricuspid regurgitation. Isolated infective tricuspid valve endocarditis is mostly confined to drug addicts, and, to out knowledge, the literature contains only four cases of this disease in children without heart disease. The present case is considered to represent an extremely rare condition.
Supraventricular Tachycardia in Acquired Rubella Infection: A Case Report
Authors: Fukushige Junichiro , Kuroiwa Tyuji , Ueda Kohji , Miyazaki Chiaki , Takagi Seiichirou 
Published: October 2007

A 6‐year‐old boy developed supraventricular tachycardia nine days after onset of the exanthem of clinical rubella. The diagnosis of rubella virus infection was confirmed serologically. Except in the neonatal period,only eight cases of cardiac involvement in acquired rubella infection have been previously reported. During epidemics.rubella virus infection should be considered in patients who manifest cardiac symptoms and signs of unknown etiology.
Treatment of Pediatric Malignant Tumors with VP‐16
Authors: Ito Masahiro , Kamiya Hitoshi , Sakurai Minoru , Akiyama Yuichi , Mikawa Haruki , Kawa Keisei , Tujino Giichi , Ueda Kazuhiro , Miyazaki Sumio 
Published: October 2007

AbstractThe West Japan Pediatric Oncology Group studied the treatment of pediatric malignant tumors with VP‐16 from December 1984 to March 1988. Study subjects were divided into two groups. One group received only VP‐16, while the other received VP‐16 combined with other anti‐tumor agents. VP‐16 evaluation was possible in a total of 116 cases. The efficacy rate was calculated by considering both complete and partial remission as effective. The efficacy rate for VP‐16 alone was 87.5% for primary cases of ANLL and 100% for primary cases of histiocytosis. The efficacy rates for combination therapy were as follows: 92.6% for primary cases of ANLL, 66.7% for primary cases of histiocytosis, 45.5% for relapsed cases of ANLL and 66.7% for relapsed cases of ALL. Bone marrow suppression was seen in the form of leukopenia and thrombocytopenia for 2 to 3 weeks after VP‐16 administration. Alopecia, mucositis and gastrointestinal symptoms were also observed, but they presented no significant problem. From our results, we believe that chemotherapy including VP‐16 is effective for remission induction therapy in primary cases of ANLL and for salvage therapy in relapsed leukemia. Additionally, VP‐16 is considered to be effective for the treatment of histiocytosis.
Intrauterine Chlamydia Trachomatis Infection in a Premature Infant
Authors: Niwa Atsuko , Ohtsuka Harumi , Inoue Tekao , Noguchi Hiroshi , Hashizume So 
Published: October 2007

AbstractIntrauterine Chlamydia trachomatis infection was strongly suspected in a premature infant born in the 32nd week of gestation. The membranes were artificially ruptured at the time of delivery. This infant showed a high titer of specific IgM antibody to Chlamydia trachomatis at one hour after birth. He showed mild respiratory distress and was treated with oral erythromycin for three weeks. He was discharged home at the age of 46 days.