bluuebunny/crossref_metadata_2025_split huggingface dataset:
Legal principles of countermeasures against violations of customs rules by the State Customs Service of Ukraine
Authors: Bukharieva Yu. V. 
Published: April 2024

The article emphasizes that Ukraine really has a carefully developed system of legal acts aimed at preventing and countering violations of customs rules. This includes constitutional norms, international agreements and domestic legislation aimed at ensuring effective customs activities and combating illegal customs activities.
It is noted that administrative and legal regulation has an important place in the system of combating violations of customs rules. The use of administrative and legal means allows to effectively respond to violations of customs regulations, promoting compliance with the established rules and ensuring the appropriate level of responsibility.
It is emphasised that, taking into account changes in modern conditions of trade and economy, it is important to update and improve legislation in the field of customs affairs constantly in order to ensure an effective and fair system of customs control.
It is determined that ensuring openness and availability of information about customs rules and procedures is a key aspect of effective customs control. High transparency contributes not only to compliance with the rules, but also builds trust in the activities of customs authorities.
Attention is focused on the fact that effective administrative and legal regulation should be aimed not only at punishing violators, but also at protecting the rights and interests of law-abiding subjects of foreign economic activity. Ensuring their legal protection is an important element of a stable business environment.
At the same time, it should be noted that in order to comply with customs regulations successfully, it is important to provide employees of the State Customs Service with the appropriate knowledge and skills. Continuous professional development of personnel is a guarantee of effective functioning of the specified customs body.
Biologi Reproduksi Ikan Gulamah (Johnius trachycephalus, Bleeker 1851) Yang Didaratkan di Tempat Pelelangan Ikan (TPI) Tanjung Beringin, Kabupaten Serdang Bedagai, Provinsi Sumatera Utara
Authors: Desrita  , Hasibuan Julia Syahriani , Manurung Vindy Rilani , Sinaga Jessica 
Published: April 2024

Penelitian ini bertujuan untuk mengetahui aspek biologi reproduksi ikan gulamah (Johnius trachycephalus) meliputi rasio kelamin, tingkat kematangan gonad, indeks kematangan gonad, ukuran pertama kali matang gonad, ukuran pertama kali ikan tertangkap, fekunditas dan diameter telur yang didaratkan di TPI Tanjung Beringin Serdang Bedagai. Penelitian ini dilaksanakan pada bulan Juni – Agustus 2022. Sampel ikan gulamah selama penelitian sebanyak 137 ekor yang terdiri dari 65 ekor ikan jantan dan 72 ekor ikan betina. Hasil reproduksi menunjukkan rasio kelamin dalam keadaan seimbang dilihat dari perbandingan ikan jantan dan betina 1:1,09. Ikan gulamah ditemukan pada TKG I-TKG IV. Indeks kematangan gonad jantan 1,109-2,383 dan betina 4,672-7,234. Ukuran pertama kali matang gonad ikan gulamah jantan berukuran 127,596 mm dan betina berukuran 122,727 mm. ukuran pertama kali ikan gulamah jantan tertangkap berukuran 146,690 mm dan betina berukuran 149,720 mm. Fekunditas telur berkisar antara 19.726-110.343 butir, diameter telur berukuran 0,123-0,710 mm. Berdasarkan data diketahui biologi reproduksi ikan gulamah di TPI Tanjung Beringin Serdang Bedagai masih dalam keadaan baik
Innovative Work Order Planning with Process Optimization Using Computer Simulation in the Automotive Industry, in the Case of Repair Workshops
Authors: Krynke Marek , Mazur Magdalena 
Published: April 2024

This article introduces a novel approach to enhance the efficiency of work schedule management in automotive repair shops during the planning phase, leveraging computer simulation techniques. The primary focus of this study is the optimization of the scheduling process, specifically the sequencing of car repairs, aimed at minimizing the average repair time. The proposed simulation model harnesses the power of the FlexSim simulation environment, incorporating an embedded optimization module. The article outlines the fundamental stages involved in constructing the simulation model, encompassing essential input data and information. Furthermore, the article presents empirical results demonstrating the significant impact of various simulation scenarios on resource utilization, production costs, and process duration.
ANALYSIS OF THE BACKPROPAGATION ALGORITHM IN PREDICTING WATER VOLUME OF PDAM TIRTAULI PEMATANG SIANTAR CITY
Authors: Ramadani Saputra , Wanto Anjar , Safii M. 
Published: April 2024

Abstract: Increasing living standards cause an increase in the need for drinking water. However, current water supply estimates are still not optimal, with water production sometimes being more or less than requirements. To estimate the amount of water, an appropriate method is needed. The method used in this research is the back propagation algorithm artificial neural network method. When developing forecasts, past data is necessary to produce accurate results. This research aims to develop a predictive model that can estimate the volume of water that will be used by PDAM Tirtauli in the future. It is hoped that this predictive model can help PDAMs in planning more efficient water supply management and can reduce the potential for water supply shortages in the future. This research uses water distribution data for the 2015-2022 period. Training data starts in 2015-2021, testing data starts in 2016-2022. In this research, results were obtained using the Matlab R2011a application. In this research, the 5 architectures used are architecture 6-53-1, 6-58-1, 6-61-1, 6-81-1, 6-87-1. Based on these five architectures, the best architecture was obtained, namely architecture 6-87-1 with a root mean square error test value of 0.00010031 and an accuracy of 92%. The results achieved in 2023 are the total water volume of PDAM Tirtauli Pematangsiantar of 189,610,426. Keywords: backpropagation; distribution; PDAM; prediction; water Abstrak: Meningkatnya taraf hidup menyebabkan meningkatnya kebutuhan akan air minum. Namun, perkiraan pasokan air saat ini masih belum optimal, dengan produksi air kadang-kadang lebih atau kurang dari kebutuhan. Untuk memperkirakan jumlah air diperlukan suatu metode yang sesuai. Metode yang digunakan dalam penelitian ini adalah metode jaringan syaraf tiruan algoritma back propagation. Saat mengembangkan perkiraan, data masa lalu diperlukan untuk menghasilkan hasil yang akurat. Penelitian ini bertujuan untuk mengembangkan model prediktif yang dapat memperkirakan volume air yang akan digunakan oleh PDAM Tirtauli di masa mendatang. Model prediktif ini diharapkan dapat membantu PDAM dalam perencanaan pengelolaan pasokan air yang lebih efisien dan dapat mengurangi potensi kekurangan pasokan air pada masa yang akan datang. Penelitian ini menggunakan data sebaran air periode 2015-2022. Data pelatihan dimulai pada tahun 2015-2021, data pengujian dimulai pada tahun 2016-2022. Pada penelitian ini diperoleh hasil dengan menggunakan aplikasi Matlab R2011a. Pada penelitian ini 5 arsitektur yang digunakan adalah arsitektur 6-53-1, 6-58-1, 6-61-1, 6-81-1, 6-87-1. Berdasarkan kelima arsitektur tersebut diperoleh arsitektur terbaik yaitu arsitektur 6-87-1 dengan nilai uji root mean square error sebesar 0,00010031 dan mendapatkan akurasi sebesar 92%. Hasil yang dicapai pada tahun 2023 adalah total volume air PDAM Tirtauli Pematangsiantar sebesar 189.610.426. Kata Kunci: air; backpropagation; distribusi; PDAM; prediksi
FORECASTING GAMIS DEMAND IN FASHION GALLERY USING WEIGHTED MOVING AVERAGE
Authors: Chan Zulvira Elisa , Kurniawan Edi , Sena Maulana Dwi 
Published: April 2024

Abstract: This research will discuss predictions of demand for robes at the Fashion Gallery. The problem that occurs is that there is often a buildup in the number of robes provided in shops, thereby increasing additional expenses, such as storage costs and demand costs. On the other hand, if there is too little stock of robes, it will result in losses because potential buyers do not get the items they need. In this case, the forecasting system will be used as a tool to solve the problem of robe accumulation. The WMA method prioritizes the most recent data points while smoothing out fluctuations. The advantage of this method is increased responsiveness to recent changes in demand patterns, contributing to more accurate forecasts by considering current information more prominently than historical data. By implementing the WMA method, it is hoped that the accumulation of robes can be avoided. From the results of prediction calculations in January 2024, it is predicted that there will be 143 adult robes, with a MAD of 7.685185, MSE 74.79938 and MAPE 5%. For small children's robes, it is predicted that there will be 56 shirts, with MAD of 8.388889, MSE of 91.16358 and MAPE of 12%. It can be concluded that the WMA method can make it easier for Fashion Gallery to predict demand for adult and children's robes in the following month.Keywords: forecasting; robe request; weighted moving average Abstrak: Dalam penelitian ini akan membahas prediksi permintaan baju gamis pada Fashion Gallery. Permasalahan yang terjadi sering terjadinya penumpukan pada jumlah baju gamis yang disediakan pada toko, sehingga meningkatkan beban tambahan, seperti biaya penyimpanan dan biaya permintaan. Sebaliknya, apabila stok gamis yang terlalu sedikit, mengakibatkan kerugian yang disebabkan karena calon pembeli tidak mendapatkan barang yang dibutuhkan. Dalam hal ini sistem forecasting akan digunakan sebagai alat bantu dalam menyelesaikan permasalahan penumpukan baju gamis. Metode WMA, lebih mementingkan titik data terkini sambil memperlancar fluktuasi. Kelebihan metode ini meningkatkan daya tanggap terhadap perubahan pola permintaan terkini, berkontribusi pada perkiraan yang lebih akurat dengan mempertimbangkan informasi terkini secara lebih menonjol dibandingkan data historis. Dengan diterapkannya metode WMA, diharapkan dapat menghindari terjadinya penumpukan baju gamis. Dari hasil perhitungan prediksi pada bulan Januari 2024, untuk baju gamis dewasa diprediksi sebanyak 143 baju, dengan MAD sebesar 7.685185, MSE 74.79938 dan MAPE 5%. Untuk baju gamis anak kecil diprediksi sebanyak 56 baju, dengan MAD sebesar 8.388889, MSE 91.16358 dan MAPE sebesar 12%. Dapat disimpulkan bahwa metode WMA dapat memudahkan Fashion Gallery dalam meramalkan permintaan baju gamis dewasa dan anak-anak pada bulan berikutnya.Kata Kunci: forecasting; permintaan baju gamis; weighted moving average
STUDI RESILIENSI REMAJA KORBAN KEKERASAN SEKSUAL DI PESANTREN X: EFEKTIVITAS INTERVENSI COGNITIVE BEHAVIORAL (CB)
Authors: Nurjannah Nurjannah , Faroh Najdah , Hidayat Fikri Nur , Afridah Mumtaz 
Published: April 2024

Kekerasan seksual merujuk pada penggunaan kekuatan fisik, ancaman, atau tindakan lain yang mengakibatkan dampak negatif terhadap seseorang atau sekelompok orang, khususnya dalam konteks seksual. Metode Penelitian Kualitatif Studi Kasus melibatkan pendekatan kualitatif dan Teknik pengumpulan data seperti Observasi, wawancara, dan analisis dokumen. Penelitian ini dapat menggunakan pendekatan kualitati yang bersifat deskriptif, interpretative dan naturalistik Hasil penelitian menunjukkan skor resiliensi meningkat setelah intervensi CB. Sehingga model CB dapat diadopsi oleh pesantren untuk meningkatkan resiliensi remaja korban kekerasan seksual. Korban mengalami dampak psikologis seperti membenci diri sendiri, trauma, dan ingin melarikan diri. Namun mereka tetap bertahan karena tekanan ekonomi keluarga. Kedua korban mendapat dukungan sosial dari pengurus pesantren sehingga membantu meningkatkan resiliensi mereka. Intervensi Cognitive-Behavioral (CB) terbukti efektif meningkatkan resiliensi remaja korban kekerasan seksual di Pesantren X. Intervensi CB membantu mengubah pola pikir negatif, mengelola emosi, dan meningkatkan keterampilan mengatasi masalah
MENINGKATKAN KREATIVITAS ANAK MELALUI PERMAIANAN KONSTRUKTIF PADA AKAN KELOMPOK A
Authors: Irfan Ahmad Zainul 
Published: April 2024

Potensi kreatif anak hanya dapat dikembangkan melalui proses kreatif yang disebabkan oleh kesempatan bermain yang mendorong tanda-tanda kreativitas pada anak usia dini.” (Yulian.N, 2020, p. 41). Berlandaskan latar belakang di atas, rumusan masalah pada riset ini yakni bagaimana permainan konstruktif mampu meningkatkan kreativitas anak kelompok A di TK AL-Barokah Lombok Timur. Berlandaskan rumusan masalah, maka tujuan riset ini yakni meningkatkan kreativitas melalui permainan konstruktif di kelompok A TK AL-Barokah Lombok Timur. Subjek penelitian ini adalah anak usia 3-4 tahun TK AL-Barokah Ajaran tahun ajaran 2023/2024 yang berjumlah 10 anak, 5 perempuan dan 5 laki-laki. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK), yang merupakan bagian dari penelitian tindakan kelompok. Hasil penelitian ini menunjukkan bahwa permainan konstruktif berperan penting dalam meningkatkan kreativitas anak Kelompok A TK AL-Barokah. Bermain konstruktif memberikan pengalaman belajar yang menyenangkan, memungkinkan anak berpikir kreatif dan mengembangkan beberapa keterampilan penting seperti keterampilan motorik halus, kerja sama, dan berbagi ide. Penelitian menunjukkan bahwa permainan konstruktif berpengaruh positif terhadap pemikiran kreatif, motorik halus dan interaksi sosial anak
El libro como instrumento de la construcción de un mundo global: los misioneros y la cultura del escrito
Authors: Romano Antonella 
Published: April 2024

En los últimos sesenta años, la investi­gación sobre los procesos de circulación de lo escrito en el Renacimiento, se ha desple­gado en numerosas direcciones a partir de los trabajos consagrados a la Historia del Libro y a la Imprenta. Cuestionar la figu­ra de los actores de la circulación de textos permite, sin embargo, reflexionar mejor so­bre las lógicas de la circulación de lo escrito y de sus espacios, invitándonos a ampliar la investigación, incluyendo nuevas dimen­siones, vinculadas con lo que fueron los mundos del Renacimiento más allá de la cuenca mediterránea, de sus culturas de la escritura y del libro. Entonces, el enfoque de los misioneros, en particular de la Com­pañía de Jesús, se revela como un punto de observación privilegiado para liberar la reflexión de una perspectiva difusionista, examinando el concepto de “textualidad” en el ámbito de los mundos letrados que se construyeron entre el Nuevo Mundo y la Vieja Europa.
The alteration of the structure and macroscopic mechanical response of porcine patellar tendon by elastase digestion
Authors: Liu Xiaoyun , Deng Yuping , Liang Zeyu , Qiao Dan , Zhang Wentian , Wang Mian , Li Feifei , Liu Jiannan , Wu Yaobing , Chen Guangxin , Liu Yan , Tan Wenchang , Xing Jian , Huang Wenhua , Zhao Dongliang , Li Yanbing 
Published: April 2024

Background: The treatment of patellar tendon injury has always been an unsolved problem, and mechanical characterization is very important for its repair and reconstruction. Elastin is a contributor to mechanics, but it is not clear how it affects the elasticity, viscoelastic properties, and structure of patellar tendon.Methods: The patellar tendons from six fresh adult experimental pigs were used in this study and they were made into 77 samples. The patellar tendon was specifically degraded by elastase, and the regional mechanical response and structural changes were investigated by: (1) Based on the previous study of elastase treatment conditions, the biochemical quantification of collagen, glycosaminoglycan and total protein was carried out; (2) The patellar tendon was divided into the proximal, central, and distal regions, and then the axial tensile test and stress relaxation test were performed before and after phosphate-buffered saline (PBS) or elastase treatment; (3) The dynamic constitutive model was established by the obtained mechanical data; (4) The structural relationship between elastin and collagen fibers was analyzed by two-photon microscopy and histology.Results: There was no statistical difference in mechanics between patellar tendon regions. Compared with those before elastase treatment, the low tensile modulus decreased by 75%–80%, the high tensile modulus decreased by 38%–47%, and the transition strain was prolonged after treatment. For viscoelastic behavior, the stress relaxation increased, the initial slope increased by 55%, the saturation slope increased by 44%, and the transition time increased by 25% after enzyme treatment. Elastin degradation made the collagen fibers of patellar tendon become disordered and looser, and the fiber wavelength increased significantly.Conclusion: The results of this study show that elastin plays an important role in the mechanical properties and fiber structure stability of patellar tendon, which supplements the structure-function relationship information of patellar tendon. The established constitutive model is of great significance to the prediction, repair and replacement of patellar tendon injury. In addition, human patellar tendon has a higher elastin content, so the results of this study can provide supporting information on the natural properties of tendon elastin degradation and guide the development of artificial patellar tendon biomaterials.
The ion channel TRPV5 regulates B-cell signaling and activation
Authors: Mahtani Trisha , Sheth Hena , Smith L. K. , Benedict Leshawn , Brecier Aurelie , Ghasemlou Nader , Treanor Bebhinn 
Published: April 2024

IntroductionB-cell activation triggers the release of endoplasmic reticulum calcium stores through the store-operated calcium entry (SOCE) pathway resulting in calcium influx by calcium release-activated calcium (CRAC) channels on the plasma membrane. B-cell-specific murine knockouts of SOCE do not impact humoral immunity suggesting that alternative channels may be important.MethodsWe identified a member of the calcium-permeable transient receptor potential (TRP) ion channel family, TRPV5, as a candidate channel expressed in B cells by a quantitative polymerase chain reaction (qPCR) screen. To further investigate the role of TRPV5 in B-cell responses, we generated a murine TRPV5 knockout (KO) by CRISPR–Cas9. ResultsWe found TRPV5 polarized to B-cell receptor (BCR) clusters upon stimulation in a PI3K–RhoA-dependent manner. TRPV5 KO mice have normal B-cell development and mature B-cell numbers. Surprisingly, calcium influx upon BCR stimulation in primary TRPV5 KO B cells was not impaired; however, differential expression of other calcium-regulating proteins, such as ORAI1, may contribute to a compensatory mechanism for calcium signaling in these cells. We demonstrate that TRPV5 KO B cells have impaired spreading and contraction in response to membrane-bound antigen. Consistent with this, TRPV5 KO B cells have reduced BCR signaling measured through phospho-tyrosine residues. Lastly, we also found that TRPV5 is important for early T-dependent antigen specific responses post-immunization. DiscussionThus, our findings identify a role for TRPV5 in BCR signaling and B-cell activation.
Non-invasive prediction of preeclampsia using the maternal plasma cell-free DNA profile and clinical risk factors
Authors: Yu Yan , Xu Wenqiu , Zhang Sufen , Feng Suihua , Feng Feng , Dai Junshang , Zhang Xiao , Tian Peirun , Wang Shunyao , Zhao Zhiguang , Zhao Wenrui , Guan Liping , Qiu Zhixu , Zhang Jianguo , Peng Huanhuan , Lin Jiawei , Zhang Qun , Chen Weiping , Li Huahua , Zhao Qiang , Xiao Gefei , Li Zhongzhe , Zhou Shihao , Peng Can , Xu Zhen , Zhang Jingjing , Zhang Rui , He Xiaohong , Li Hua , Li Jia , Ruan Xiaohong , Zhao Lijian , He Jun 
Published: April 2024

BackgroundPreeclampsia (PE) is a pregnancy complication defined by new onset hypertension and proteinuria or other maternal organ damage after 20 weeks of gestation. Although non-invasive prenatal testing (NIPT) has been widely used to detect fetal chromosomal abnormalities during pregnancy, its performance in combination with maternal risk factors to screen for PE has not been extensively validated. Our aim was to develop and validate classifiers that predict early- or late-onset PE using the maternal plasma cell-free DNA (cfDNA) profile and clinical risk factors.MethodsWe retrospectively collected and analyzed NIPT data of 2,727 pregnant women aged 24–45 years from four hospitals in China, which had previously been used to screen for fetal aneuploidy at 12 + 0 ~ 22 + 6 weeks of gestation. According to the diagnostic criteria for PE and the time of diagnosis (34 weeks of gestation), a total of 143 early-, 580 late-onset PE samples and 2,004 healthy controls were included. The wilcoxon rank sum test was used to identify the cfDNA profile for PE prediction. The Fisher’s exact test and Mann–Whitney U-test were used to compare categorical and continuous variables of clinical risk factors between PE samples and healthy controls, respectively. Machine learning methods were performed to develop and validate PE classifiers based on the cfDNA profile and clinical risk factors.ResultsBy using NIPT data to analyze cfDNA coverages in promoter regions, we found the cfDNA profile, which was differential cfDNA coverages in gene promoter regions between PE and healthy controls, could be used to predict early- and late-onset PE. Maternal age, body mass index, parity, past medical histories and method of conception were significantly differential between PE and healthy pregnant women. With a false positive rate of 10%, the classifiers based on the combination of the cfDNA profile and clinical risk factors predicted early- and late-onset PE in four datasets with an average accuracy of 89 and 80% and an average sensitivity of 63 and 48%, respectively.ConclusionIncorporating cfDNA profiles in classifiers might reduce performance variations in PE models based only on clinical risk factors, potentially expanding the application of NIPT in PE screening in the future.
A Mendelian randomization study on the causal effects of circulating cytokines on the risk of vitiligo
Authors: Liu Chengling , Liu Xingchen , Xin Haiming , Li Xin 
Published: April 2024

BackgroundAccumulating evidence reveals an association between circulating cytokine levels and vitiligo. However, the causal association between circulating cytokine levels and vitiligo remains unrevealed.MethodsWe performed a two-sample Mendelian randomization (MR) analysis using a genome-wide association study of the 41 cytokines dataset, which was conducted with 3 Finnish cohorts (n = 8,293). Vitiligo data were acquired from strictly defined vitiligo data collected by FinnGenbiobank analysis, which included 207,613 European ancestors (131 vitiligo patients, 207,482 controls). The inverse-variance weighted (IVW) method, weighted median (WME), simple model, weighted model, and MR-Egger were used to determine the changes in vitiligo pathogenic cytokine taxa, followed by sensitivity analysis, including horizontal pleiotropy analysis. The MR Steiger test evaluated the strength of a causal association, and the leave-one-out method was used to assess the reliability of the results. The possibility of reverse causality was also investigated using a reverse MR study.ResultsWe observed that rising IL-4 levels generated an enhanced probability of vitiligo in IVW (OR 2.72, 95%CI 1.19–6.22, p = 0.018). According to the results of the MR analysis, there were causal links between IL-4 and vitiligo. Results were steady after sensitivity and heterogeneity analyses.ConclusionOur research reveals that a genetically determined increased level of circulating IL-4 may be linked to a higher risk of developing vitiligo. The development of innovative treatment approaches (such as tofacitinib or dupilumab) that focus on blocking IL-4 as a novel way of preventing and treating vitiligo is significantly impacted by our findings.