bluuebunny/crossref_metadata_2025_split huggingface dataset:
The uniform distribution modulo one of certain subsequences of ordinates of zeros of the zeta function
Authors: ÇİÇEK FATMA , GONEK STEVEN M. 
Published: March 2024

AbstractOn the assumption of the Riemann hypothesis and a spacing hypothesis for the nontrivial zeros
$1/2+i\gamma$
of the Riemann zeta function, we show that the sequence
\begin{equation*}\Gamma_{[a, b]} =\Bigg\{ \gamma : \gamma>0 \quad \mbox{and} \quad \frac{ \log\big(| \zeta^{(m_{\gamma })} (\frac12+ i{\gamma }) | / (\!\log{{\gamma }} )^{m_{\gamma }}\big)}{\sqrt{\frac12\log\log {\gamma }}} \in [a, b] \Bigg\},\end{equation*}
where the
${\gamma }$
are arranged in increasing order, is uniformly distributed modulo one. Here a and b are real numbers with
$a<b$
, and
$m_\gamma$
denotes the multiplicity of the zero
$1/2+i{\gamma }$
. The same result holds when the
${\gamma }$
’s are restricted to be the ordinates of simple zeros. With an extra hypothesis, we are also able to show an equidistribution result for the scaled numbers
$\gamma (\!\log T)/2\pi$
with
${\gamma }\in \Gamma_{[a, b]}$
and
$0<{\gamma }\leq T$
.
Disasters and the rise of global religious philanthropy
Authors: Cornelio Jayeel , Teehankee Julio C. 
Published: March 2024

AbstractThis article seeks to make sense of the rise of global religious philanthropy in relation to disaster. Global religious philanthropy refers to the transnational activities of religious organizations to respond to humanitarian crisis. These organizations can be faith-based initiatives or religious groups or denominations that have created humanitarian services for the specific purpose of relief and recovery in other countries. The first part spells out what we mean by the rise of global religious philanthropy in disaster response. It is not so much a shift as it is a rediscovery of the religious roots of humanitarian work. But at the same time, it is also a contemporary development that is part of the globalization of risk, humanitarian aid, and religion itself. The second part will explain the rise in two ways. First, faith-based and religious organizations hold what we describe as a global imaginary. In this imaginary, the world is in crisis and it offers an opportunity to demonstrate global compassion. Second, the rise of global religious philanthropy is also tied to the expansion of religious movements, some of which are in emerging economies. The expansion renders the religious field competitive. This is why, in a paradoxical manner, their humanitarian activities are also acts of strength and power that contend with the state and other players in the religious field.
Maternal alcohol dependence symptoms, maternal insensitivity to children’s distress, and young children’s blunted emotional reactivity
Authors: Jacques Debrielle T. , Sturge-Apple Melissa L. , Davies Patrick T. , Cicchetti Dante 
Published: March 2024

Abstract
Maternal insensitivity to children’s emotional distress (e.g., expressions of sadness or fearfulness) is one mechanism through which maternal alcohol dependence may increase children’s risk for psychopathology. Although emotion dysregulation is consistently associated with psychopathology, it remains unclear how or why alcohol dependence’s effects on caregiving responses to children’s distress may impact children’s emotion regulation over time, particularly in ways that may engender risks for psychopathology. This study examined longitudinal associations between lifetime maternal alcohol dependence symptoms, mothers’ insensitivity to children’s emotional distress cues, and children’s emotional reactivity among 201 mother-child dyads (Mchild age = 2.14 years; 56% Black; 11% Latino). Structural equation modeling analyses revealed a significant mediational pathway such that maternal alcohol dependence predicted increases in mothers’ insensitivity to children’s emotional distress across a one-year period (β = .16, p = .013), which subsequently predicted decreases in children’s emotional reactivity one year later (β = −.29, p = .009). Results suggest that mothers with alcohol dependence symptoms may struggle to sensitively respond to children’s emotional distress, which may prompt children to suppress or hide their emotions as an adaptive, protective strategy. The potential developmental benefits and consequences of early, protective expressive suppression strategies are discussed via developmental psychopathology frameworks.
Brain potentials reveal reduced sensitivity to negative content during second language production
Authors: Jończyk Rafał , Naranowicz Marcin , Bel-Bahar Tarik S. , Jankowiak Katarzyna , Korpal Paweł , Bromberek-Dyzman Katarzyna , Thierry Guillaume 
Published: March 2024

Abstract
Prior research suggests that bilinguals show reduced sensitivity to negative content when operating in the second language (L2). The available evidence, however, is limited to language comprehension. We tested the production of emotional words in Polish (L1)–English (L2) bilinguals in two EEG studies that manipulated emotional cueing. In Experiment 1 (neutral context), white or black circles indicated whether participants should read aloud (shadow) or translate a subsequently presented word. N400 amplitudes were selectively reduced for negative L2 words regardless of the task. In Experiment 2 (emotional context), we used black or white emojis, either sad or neutral, as cues. The previous interaction between word valence and language of operation vanished, but late positive potential amplitudes elicited by negative words were larger for translation from L2 to L1 (i.e., production in Polish) than L1 to L2. These results validate and extend to production previous findings of attenuated emotional response in L2 comprehension.
The Spelling Problem
Authors: Bainbridge Anthony F. 
Published: March 2024

AbstractIt is generally accepted by scholars that the songs of Homer were first written in ~ 700 BCE; the text seems to spring fully formed into a still illiterate world, demonstrating in a sophisticated vocabulary the first example of the use of a new alphabet. The language used is a never-spoken construct; its construction represents the first use of an alphabet enabling words to be written. This paper aims to open a discussion on the means by which spelling emerged, either democratically or as the work of one man.
Fluid‐Driven Mass Transfer During Retrograde Metamorphism and Exhumation of the UHP Western Gneiss Region Terrane, Norway
Authors: Shulaker D. Z. , Gordon S. M. , Hammerli J. , DesOrmeau J. W. 
Published: March 2024

AbstractDehydration reactions within subducted oceanic crust are important for fluid‐mediated element transfer within the subducting plate and potentially to the mantle wedge. The effects of metamorphic reactions and fluid flow on element recycling that occur during retrogression and exhumation of subducted continental crust from mantle depths are poorly understood. We study two metabasite pods with fresh eclogite cores and retrogressed amphibolite‐facies rims and surrounding host gneiss within the Western Gneiss Region (WGR), Norway, to better understand element mobility and mass transfer during exhumation of subducted continental crust. Bulk‐rock data were collected from samples taken across the pod and into the host gneiss. Phengite breakdown in eclogite and epidote recrystallization in veins and/or gneiss within pod cores contributed large ion lithophile elements and REE to retrogressed eclogite closest to the pod cores. In gneiss hosting the pods, phengite and epidote breakdown provided fluid that mediated elemental transfer and redistribution to the pod rim or tail. Compared to the studied pod in the southern WGR, the pod in the northern WGR underwent higher P‐T conditions, partial melting and higher strain rates. This resulted in the infiltration of external fluid farther into the pod interior from the rim and facilitated larger mass gain in trace elements in the amphibolite tail of the pod relative to fresh eclogite in the core. The results show clear evidence for retrogression dehydration reactions driving significant fluid‐mediated element redistribution as observed on the outcrop scale during exhumation following ultrahigh‐pressure metamorphism, which directly impacts element signatures within the exhuming crust.
Seismological Constraints on the Causes of Intraplate Earthquakes in Yangjiang Region, South China
Authors: Li Lun , Zhang Jinming , Shen Xuzhang , Wang Xiaona , He Jialong , Zhao Lingfeng , Deng Zhihui , Gao Rui 
Published: March 2024

AbstractLarge earthquakes that occur away from plate boundaries (i.e., large intraplate earthquakes), though rare, could cause heavy damage. Understanding their causes could help with seismic hazard assessment. In this study, we image the seismogenic structure under the 1969 Ms6.4 Yangjiang intraplate earthquake within the stable South China Block with a high‐resolution three‐dimensional shear‐wave velocity model constructed from ambient noise tomography based on a dense nodal seismic array. The model images relatively low velocities at a fault intersection region from the surface to at least 13 km depth in the Yangjiang seismogenic zone. Given spatial links among the intersection zone of faults, surface seawater, and low velocities, we interpret the low velocities to reflect the presence of seawater‐filled, highly fractured rocks created by the intersection of faults. We infer that the seawater infiltration through densely‐fractures could have elevated pore pressure in the long term, as evidenced by low earthquake b values at 8–13 km depths. We hypothesize that this long‐term seawater infiltration could have lowered the stress threshold of earthquake occurrence and contributed to the generation of the 1969 Ms6.4 Yangjiang earthquake. We propose that the large intraplate earthquakes within stable plates tend to occur in regional weakening regions (e.g., fault intersections) favorable to stress buildup. Given sufficient tectonic stress accumulation, the long‐term hydrologically driven crustal stress variations could play an essential role in triggering large intraplate earthquakes. This study could potentially contribute to improving seismic hazard assessment in the Guangdong‐Hong Kong‐Macao‐Greater‐Bay‐Area, China.
The Manantiales Basin, Southern Central Andes (∼32°S), Preserves a Record of Late Eocene–Miocene Episodic Growth of an East‐Vergent Orogenic Wedge
Authors: Ronemus Chance B. , Howlett Caden J. , DeCelles Peter G. , Carrapa Barbara , George Sarah W. M. 
Published: March 2024

AbstractThe Manantiales basin contains >4 km of nonmarine sedimentary strata that accumulated at 31.75–32.5°S during construction of the High Andes. We report field and analytical data from the underexplored northern portion of this basin. The basin contains upper Eocene–middle Miocene strata that accumulated in back‐bulge or distal foredeep through inner‐wedge‐top depozones of the Andean foreland basin as it migrated through this region. A revised accumulation history for the basin‐filling Río de los Patos and Chinches Formations supports a regional pattern of flexure in front of an east‐vergent orogenic wedge. The former formation consists of eolian and localized fluviolacustrine deposits which accumulated between ca. 38 Ma and ≤34 Ma during thrust belt development in Chile. A subsequent ≤12 Myr hiatus may reflect passage of the flexural forebulge or cessation of subsidence during orogenic quiescence. The overlying Chinches Formation records a transition from the foredeep to wedge‐top depozones. Foredeep deposits of east‐flowing, meandering streams were incised prior to ca. 18 Ma, after which deposits of axial rivers, playas, and perennial lakes ponded in a depression behind orogenic topography to the east. After ca. 15 Ma, alluvial‐fan deposits were syndepositionally deformed adjacent to growing thrust‐belt structures along the western basin margin. Although the basin record supports a westward step in the locus of deformation during Early–Middle Miocene time, it conflicts with models involving west‐vergence of the orogenic wedge. Rather, this pattern can be explained as out‐of‐sequence deformation alternating with wedge forward propagation, consistent with Coulomb wedge models incorporating syntectonic sedimentation.
Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity
Authors: Yoon Jihoon G. , Jang Dong Geon , Cho Sung-Gyu , Lee Chaeyoung , Noh Shin Hye , Seo Soo Kyung , Yu Jung Woo , Chung Hyeon Woo , Han KyeoRe , Kwon Soon Sung , Han Dai Hoon , Oh Jaeseong , Jang In-Jin , Kim Sang-Hoon , Jee Young-Koo , Lee Hyun , Park Dong Won , Sohn Jang Won , Yoon Ho Joo , Kim Chul Hoon , Lee Jae Myun , Kim Sang-Heon , Lee Min Goo 
Published: March 2024

AbstractAnti-tuberculosis (AT) medications, including isoniazid (INH), can cause drug-induced liver injury (DILI), but the underlying mechanism remains unclear. In this study, we aimed to identify genetic factors that may increase the susceptibility of individuals to AT-DILI and to examine genetic interactions that may lead to isoniazid (INH)-induced hepatotoxicity. We performed a targeted sequencing analysis of 380 pharmacogenes in a discovery cohort of 112 patients (35 AT-DILI patients and 77 controls) receiving AT treatment for active tuberculosis. Pharmacogenome-wide association analysis was also conducted using 1048 population controls (Korea1K). NAT2 and ATP7B genotypes were analyzed in a replication cohort of 165 patients (37 AT-DILI patients and 128 controls) to validate the effects of both risk genotypes. NAT2 ultraslow acetylators (UAs) were found to have a greater risk of AT-DILI than other genotypes (odds ratio [OR] 5.6 [95% confidence interval; 2.5–13.2], P = 7.2 × 10−6). The presence of ATP7B gene 832R/R homozygosity (rs1061472) was found to co-occur with NAT2 UA in AT-DILI patients (P = 0.017) and to amplify the risk in NAT2 UA (OR 32.5 [4.5–1423], P = 7.5 × 10−6). In vitro experiments using human liver-derived cell lines (HepG2 and SNU387 cells) revealed toxic synergism between INH and Cu, which were strongly augmented in cells with defective NAT2 and ATP7B activity, leading to increased mitochondrial reactive oxygen species generation, mitochondrial dysfunction, DNA damage, and apoptosis. These findings link the co-occurrence of ATP7B and NAT2 genotypes to the risk of INH-induced hepatotoxicity, providing novel mechanistic insight into individual AT-DILI susceptibility.
Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer
Authors: Bae Taegeun , Hallis Steffanus Pranoto , Kwak Mi-Kyoung 
Published: March 2024

AbstractOxygen is crucial for life and acts as the final electron acceptor in mitochondrial energy production. Cells adapt to varying oxygen levels through intricate response systems. Hypoxia-inducible factors (HIFs), including HIF-1α and HIF-2α, orchestrate the cellular hypoxic response, activating genes to increase the oxygen supply and reduce expenditure. Under conditions of excess oxygen and resulting oxidative stress, nuclear factor erythroid 2-related factor 2 (NRF2) activates hundreds of genes for oxidant removal and adaptive cell survival. Hypoxia and oxidative stress are core hallmarks of solid tumors and activated HIFs and NRF2 play pivotal roles in tumor growth and progression. The complex interplay between hypoxia and oxidative stress within the tumor microenvironment adds another layer of intricacy to the HIF and NRF2 signaling systems. This review aimed to elucidate the dynamic changes and functions of the HIF and NRF2 signaling pathways in response to conditions of hypoxia and oxidative stress, emphasizing their implications within the tumor milieu. Additionally, this review explored the elaborate interplay between HIFs and NRF2, providing insights into the significance of these interactions for the development of novel cancer treatment strategies.
IL-27-induced PD-L1highSca-1+ innate lymphoid cells suppress contact hypersensitivity in an IL-10-dependent manner
Authors: Min Keun Young , Kim Do-Kyun , Jo Min Geun , Choi min Yeong , Lee Dajeong , Park Jeong Won , Park Young-Jun , Chung Yeonseok , Kim Young Mi , Park Yeong-Min , Kim Hyuk Soon , Choi Wahn Soo 
Published: March 2024

AbstractInnate lymphoid cells (ILCs) play an important role in maintaining tissue homeostasis and various inflammatory responses. ILCs are typically classified into three subsets, as is the case for T-cells. Recent studies have reported that IL-10-producing type 2 ILCs (ILC210s) have an immunoregulatory function dependent on IL-10. However, the surface markers of ILC210s and the role of ILC210s in contact hypersensitivity (CHS) are largely unknown. Our study revealed that splenic ILC210s are extensively included in PD-L1highSca-1+ ILCs and that IL-27 amplifies the development of PD-L1highSca-1+ ILCs and ILC210s. Adoptive transfer of PD-L1highSca-1+ ILCs suppressed oxazolone-induced CHS in an IL-10-dependent manner Taken together, our results demonstrate that ILC210s are critical for the control of CHS and suggest that ILC210s can be used as target cells for the treatment of CHS.
Expert consensus on irrigation and intracanal medication in root canal therapy
Authors: Zou Xiaoying , Zheng Xin , Liang Yuhong , Zhang Chengfei , Fan Bing , Liang Jingping , Ling Junqi , Bian Zhuan , Yu Qing , Hou Benxiang , Chen Zhi , Wei Xi , Qiu Lihong , Chen Wenxia , He Wenxi , Xu Xin , Meng Liuyan , Zhang Chen , Chen Liming , Deng Shuli , Lei Yayan , Xie Xiaoli , Wang Xiaoyan , Yu Jinhua , Zhao Jin , Shen Song , Zhou Xuedong , Yue Lin 
Published: March 2024

AbstractChemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes. Additionally, ambiguous clinical indications for root canal medication and non-standardized dressing protocols must be clarified. Inappropriate intracanal medication may present side effects and jeopardize the therapeutic outcomes. Indeed, clinicians have been aware of these concerns for years. Based on the current evidence of studies, this article reviews the properties of various irrigants and intracanal medicaments and elucidates their effectiveness and interactions. The evolution of different kinetic irrigation methods, their effects, limitations, the paradigm shift, current indications, and effective operational procedures regarding intracanal medication are also discussed. This expert consensus aims to establish the clinical operation guidelines for root canal irrigation and a position statement on intracanal medication, thus facilitating a better understanding of infection control, standardizing clinical practice, and ultimately improving the success of endodontic therapy.
Expert consensus on difficulty assessment of endodontic therapy
Authors: Huang Dingming , Wang Xiaoyan , Liang Jingping , Ling Junqi , Bian Zhuan , Yu Qing , Hou Benxiang , Chen Xinmei , Li Jiyao , Ye Ling , Cheng Lei , Xu Xin , Hu Tao , Wu Hongkun , Guo Bin , Su Qin , Chen Zhi , Qiu Lihong , Chen Wenxia , Wei Xi , Huang Zhengwei , Yu Jinhua , Lin Zhengmei , Zhang Qi , Yang Deqin , Zhao Jin , Pan Shuang , Yang Jian , Wu Jiayuan , Pan Yihuai , Xie Xiaoli , Deng Shuli , Huang Xiaojing , Zhang Lan , Yue Lin , Zhou Xuedong 
Published: March 2024

AbstractEndodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the removal of inflamed or necrotic pulp tissue and the replacement by gutta-percha. However, it is very essential for endodontic treatment to debride the root canal system and prevent the root canal system from bacterial reinfection after root canal therapy (RCT). Recent research, encompassing bacterial etiology and advanced imaging techniques, contributes to our understanding of the root canal system’s anatomy intricacies and the technique sensitivity of RCT. Success in RCT hinges on factors like patients, infection severity, root canal anatomy, and treatment techniques. Therefore, improving disease management is a key issue to combat endodontic diseases and cure periapical lesions. The clinical difficulty assessment system of RCT is established based on patient conditions, tooth conditions, root canal configuration, and root canal needing retreatment, and emphasizes pre-treatment risk assessment for optimal outcomes. The findings suggest that the presence of risk factors may correlate with the challenge of achieving the high standard required for RCT. These insights contribute not only to improve education but also aid practitioners in treatment planning and referral decision-making within the field of endodontics.
Photo-responsive functional materials based on light-driven molecular motors
Authors: Deng Yanping , Long Guiying , Zhang Yang , Zhao Wei , Zhou Guofu , Feringa Ben L. , Chen Jiawen 
Published: March 2024

AbstractIn the past two decades, the research and development of light-triggered molecular machines have mainly focused on developing molecular devices at the nanoscale. A key scientific issue in the field is how to amplify the controlled motion of molecules at the nanoscale along multiple length scales, such as the mesoscopic or the macroscopic scale, or in a more practical perspective, how to convert molecular motion into changes of properties of a macroscopic material. Light-driven molecular motors are able to perform repetitive unidirectional rotation upon irradiation, which offers unique opportunities for responsive macroscopic systems. With several reviews that focus on the design, synthesis and operation of the motors at the nanoscale, photo-responsive macroscopic materials based on light-driven molecular motors have not been comprehensively summarized. In the present review, we first discuss the strategy of confining absolute molecular rotation into relative rotation by grafting motors on surfaces. Secondly, examples of self-assemble motors in supramolecular polymers with high internal order are illustrated. Moreover, we will focus on building of motors in a covalently linked system such as polymeric gels and polymeric liquid crystals to generate complex responsive functions. Finally, a perspective toward future developments and opportunities is given. This review helps us getting a more and more clear picture and understanding on how complex movement can be programmed in light-responsive systems and how man-made adaptive materials can be invented, which can serve as an important guideline for further design of complex and advanced responsive materials.