bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualification test campaign of RFA one fairing engineering model
Authors: Meireles P , Hooton J , Colaço L , Alonso D , Pinheiro L 
Published: March 2024

Abstract
The fairing is an important element of the rocket as it protects the payload from the external environment during the most aggressive phases of the flight. A test campaign was developed with the aim of qualifying the fairing structure of the RFA One. This test is intended to simulate the quasi-static loads of the most critical phase during flight. A FEA model was developed to identify the most critical phase of flight and to identify the quasi-static reactions that replicate the flight loads. Based on these reactions, the loads and test levels were defined. The test results were compared with the FEA data to correlate and improve the model. The static test was successfully performed at acceptance and qualification Level 2. The load and strain results indicate that the DLL was achieved and exceeded by a factor of 1.11, while the fairing maintained its functionality and key performance. This paper presents the most relevant results of the test, discusses the results compared with the FEA model and summarizes some lessons drawn from the test campaign.
Influences of temperature on the property of ITO/Teflon/Ag in atomic oxygen environment
Authors: Guo Liang , Qiu Tiecheng , Zhang Qian , Guo Zhanping , Shan Ming 
Published: March 2024

Abstract
This paper uses ground simulation equipment for an atomic oxygen environment to conduct experimental research on ITO/Teflon/Ag, which is used in spacecraft using an atomic oxygen environment. The atomic oxygen integrated flux selected in the study is 9.1× 1019 atoms/cm2, with a vacuum degree of 10-2 Pa, and sample temperatures of 20°C, 70°C, and 120°C, respectively, were selected to investigate the possible impact of sample temperature on atomic oxygen environment simulation experiments. After the test, a high-precision microelectronic balance was used to test the mass loss of the sample and calculate the reaction rate of the material. The thermal emissivity and solar absorption ratio of the sample were tested using TEMP 2000A and LPSR 300, respectively. Through experiments and analysis, it was found that as the sample temperature increased, the ITO/Teflon/Ag reaction rate with atomic oxygen gradually increased but remained at 10-25. Atomic oxygen and temperature have a significant impact on the thermal physical properties of the material.
Research on the performance of pavement crack repair materials based on foaming polyurethane
Authors: Zhou You , Chen Fei , Xu Zhoucong 
Published: March 2024

Abstract
In this paper, Pucs, a new two-component foaming polyurethane material, is selected to carry out a feasibility study on its application in pavement crack repair. Based on the two common crack repair materials in current projects, tests of pavement performance of repair materials are carried out, such as bonding performance, water damage resistance performance, high-temperature performance, and aging resistance performance. The comparative analysis of the results reveals that Pucs have better pavement performance than conventional crack repair materials. This indicates that Pucs is a new kind of material with excellent performance in pavement crack repair and can be widely used in the field of crack repair.
Characteristics of bioplastics prepared from cassava starch reinforced with banana bunch cellulose at various concentrations
Authors: Saputri C A , Julyatmojo F A , Harmiansyah  , Febrina M , Mahardika M , Maulana S 
Published: March 2024

Abstract
Human activities have led to the pollution of the environment through the accumulation of plastic waste. Since plastics are resistant to decomposition resulting negative impact on the environment, there is a pressing need for the development of bioplastics. Starch is a such of natural material that can be used made of bioplastics. However, bioplastics from starch were needed to improve starch-based bioplastics due to their brittle properties. To address this issue, researchers focused on enhancing starch-based bioplastics by incorporating cellulose, particularly derived from kepok banana bunch fibers and cassava starch variety UJ3. The production process involved adding varying concentrations of 2.5, 5, 7.5, and 10 % (wt) of kepok banana bunch cellulose. The findings indicated that increasing cellulose concentration improved the characteristics of the bioplastic materials significantly. The results showed that the addition of cellulose concentration improved the mechanical properties, water vapor absorption, and biodegradability of bioplastics. With an optimal cellulose concentration level at 7.5%, remarkable enhancements in tensile strength (from 2.92 to 6.72 MPa), reduced elongation percentage (from 20.89 to 4.06%), increased Young’s Modulus values (from 13.98 to 172.52 MPa), decreased water vapor absorption rate (from 15,93 to 11,48%), and enhanced bio-degradability rating (from 29,81 to 50,69%) were observed.
Slicing knots in definite 4-manifolds
Authors: Kjuchukova Alexandra , Miller Allison , Ray Arunima , Sakallı Sümeyra 
Published: March 2024

We study the

C
P

2

\mathbb {CP}^2

-slicing number of knots, i.e. the smallest

m
≥
0

m\geq 0

such that a knot

K
⊆

S
3

K\subseteq S^3

bounds a properly embedded, null-homologous disk in a punctured connected sum

(

#
m

C
P

2

)

×

(\#^m\mathbb {CP}^2)^{\times }

. We find knots for which the smooth and topological

C
P

2

\mathbb {CP}^2

-slicing numbers are both finite, nonzero, and distinct. To do this, we give a lower bound on the smooth

C
P

2

\mathbb {CP}^2

-slicing number of a knot in terms of its double branched cover and an upper bound on the topological

C
P

2

\mathbb {CP}^2

-slicing number in terms of the Seifert form.
Aortic Calcification is Associated With the Difference Between Invasive Central and Cuff-Measured Brachial Blood Pressure in Chronic Kidney Disease
Authors: Nyvad Jakob , Christensen Kent Lodberg , Andersen Gratien , Reinhard Mark , Maeng Michael , Nielsen Sebastian , Thomsen Martin Bjergskov , Jensen Jesper Møller , Nørgaard Bjarne Linde , Buus Niels Henrik 
Published: March 2024

Abstract

BACKGROUND
Chronic kidney disease (CKD) is associated with accelerated vascular calcification and increased central systolic blood pressure when measured invasively (invCSBP) relative to cuff-based brachial systolic blood pressure (cuffSBP). The contribution of aortic wall calcification to this phenomenon has not been clarified. We, therefore, examined the effects of aortic calcification on cuffSBP and invCSBP in a cohort of patients representing all stages of CKD.

METHODS
During elective coronary angiography, invCSBP was measured in the ascending aorta with a fluid-filled catheter with simultaneous recording of cuffSBP using an oscillometric device. Furthermore, participants underwent a non-contrast computed tomography scan of the entire aorta with observer-blinded calcification scoring of the aortic wall ad modum Agatston.

RESULTS
We included 168 patients (mean age 67.0 ± 10.5, 38 females) of whom 38 had normal kidney function, while 30, 40, 28, and 32 had CKD stages 3a, 3b, 4, and 5, respectively. Agatston scores adjusted for body surface area ranged from 48 to 40,165. We found that invCSBP increased 3.6 (95% confidence interval 1.4–5.7) mm Hg relative to cuffSBP for every 10,000-increment in aortic Agatston score. This association remained significant after adjustment for age, diabetes, antihypertensive treatment, smoking, eGFR, and BP level. No such association was found for diastolic BP.

CONCLUSIONS
Patients with advanced aortic calcification have relatively higher invCSBP for the same cuffSBP as compared to patients with less calcification. Advanced aortic calcification in CKD may therefore result in hidden central hypertension despite apparently well-controlled cuffSBP. ClinicalTrials.gov identifier: NCT04114695.
Convenient pre-separation method depends on negative charges suitable for glycan sequencing analysis
Authors: Segawa Shigemitsu , Natsuka Shunji 
Published: March 2024

Abstract
For precise structural analysis of complex glycans, it is necessary to fractionate glycans based on acidity prior to liquid chromatography-mass spectrometry analysis. Conventional fractionation using high-performance liquid chromatography is time consuming and not high throughput. Therefore, we developed a rapid method for the fractionation using a small cartridge column. This enables rapid multi-sample processing for glycan sequencing.
Functional support vector machine
Authors: Xie Shanghong , Ogden R Todd 
Published: March 2024

Abstract
Linear and generalized linear scalar-on-function modeling have been commonly used to understand the relationship between a scalar response variable (e.g. continuous, binary outcomes) and functional predictors. Such techniques are sensitive to model misspecification when the relationship between the response variable and the functional predictors is complex. On the other hand, support vector machines (SVMs) are among the most robust prediction models but do not take account of the high correlations between repeated measurements and cannot be used for irregular data. In this work, we propose a novel method to integrate functional principal component analysis with SVM techniques for classification and regression to account for the continuous nature of functional data and the nonlinear relationship between the scalar response variable and the functional predictors. We demonstrate the performance of our method through extensive simulation experiments and two real data applications: the classification of alcoholics using electroencephalography signals and the prediction of glucobrassicin concentration using near-infrared reflectance spectroscopy. Our methods especially have more advantages when the measurement errors in functional predictors are relatively large.
Hyperlink communities in higher-order networks
Authors: Lotito Quintino Francesco , Musciotto Federico , Montresor Alberto , Battiston Federico 
Published: March 2024

Abstract
Many networks can be characterized by the presence of communities, which are groups of units that are closely linked. Identifying these communities can be crucial for understanding the system’s overall function. Recently, hypergraphs have emerged as a fundamental tool for modelling systems where interactions are not limited to pairs but may involve an arbitrary number of nodes. In this study, we adopt a dual approach to community detection and extend the concept of link communities to hypergraphs. This extension allows us to extract informative clusters of highly related hyperedges. We analyse the dendrograms obtained by applying hierarchical clustering to distance matrices among hyperedges across a variety of real-world data, showing that hyperlink communities naturally highlight the hierarchical and multiscale structure of higher-order networks. Moreover, hyperlink communities enable us to extract overlapping memberships from nodes, overcoming limitations of traditional hard clustering methods. Finally, we introduce higher-order network cartography as a practical tool for categorizing nodes into different structural roles based on their interaction patterns and community participation. This approach aids in identifying different types of individuals in a variety of real-world social systems. Our work contributes to a better understanding of the structural organization of real-world higher-order systems.
Talking to Our Sons: The Power of the Reproductive Sphere in Agnès Agboton’s and Najat El Hachmi’s Autobiographies
Authors: Utiger Julia Teresa 
Published: March 2024

Abstract
In their autobiographies Más allá del mar de arena (2005) and Jo també sóc catalana (2004), Agnès Agboton and Najat El Hachmi narrate their diasporic experience of living and mothering in Catalonia. In both cases, the narrators address their sons. The close connection between the mothers (narrators) and their sons (addressees) establishes an intimate space of power which is analyzed through Irene Gedalof’s concept of the reproductive sphere. This essay proposes that the authors of both texts establish mothering in the diaspora within autobiographical narratives as a site of negotiation, creation of identity, and intervention both for the addressees and for a larger audience.
Highly Resolved Genomes of Two Closely Related Lineages of the Rodent Louse Polyplax serrata with Different Host Specificities
Authors: Martinů Jana , Tarabai Hassan , Štefka Jan , Hypša Václav 
Published: March 2024

Abstract
Sucking lice of the parvorder Anoplura are permanent ectoparasites with specific lifestyle and highly derived features. Currently, genomic data are only available for a single species, the human louse Pediculus humanus. Here, we present genomes of two distinct lineages, with different host spectra, of a rodent louse Polyplax serrata. Genomes of these ecologically different lineages are closely similar in gene content and display a conserved order of genes, with the exception of a single translocation. Compared with P. humanus, the P. serrata genomes are noticeably larger (139 vs. 111 Mbp) and encode a higher number of genes. Similar to P. humanus, they are reduced in sensory-related categories such as vision and olfaction. Utilizing genome-wide data, we perform phylogenetic reconstruction and evolutionary dating of the P. serrata lineages. Obtained estimates reveal their relatively deep divergence (∼6.5 Mya), comparable with the split between the human and chimpanzee lice P. humanus and Pediculus schaeffi. This supports the view that the P. serrata lineages are likely to represent two cryptic species with different host spectra. Historical demographies show glaciation-related population size (Ne) reduction, but recent restoration of Ne was seen only in the less host-specific lineage. Together with the louse genomes, we analyze genomes of their bacterial symbiont Legionella polyplacis and evaluate their potential complementarity in synthesis of amino acids and B vitamins. We show that both systems, Polyplax/Legionella and Pediculus/Riesia, display almost identical patterns, with symbionts involved in synthesis of B vitamins but not amino acids.
Cognitive Functioning and the Quality of Survey Responses: An Individual Participant Data Meta-Analysis of 10 Epidemiological Studies of Aging
Authors: Schneider Stefan , Lee Pey-Jiuan , Hernandez Raymond , Junghaenel Doerte U , Stone Arthur A , Meijer Erik , Jin Haomiao , Kapteyn Arie , Orriens Bart , Zelinski Elizabeth M 
Published: March 2024

Abstract

Objectives
Self-reported survey data are essential for monitoring the health and well-being of the population as it ages. For studies of aging to provide precise and unbiased results, it is necessary that the self-reported information meets high psychometric standards. In this study, we examined whether the quality of survey responses in panel studies of aging depends on respondents’ cognitive abilities.

Methods
Over 17 million survey responses from 157,844 participants aged 50 years and older in 10 epidemiological studies of aging were analyzed. We derived 6 common statistical indicators of response quality from each participant’s data and estimated the correlations with participants’ cognitive test scores at each study wave. Effect sizes (correlations) were synthesized across studies, cognitive tests, and waves using individual participant data meta-analysis methods.

Results
Respondents with lower cognitive scores showed significantly more missing item responses (overall effect size ρ^ = −0.144), random measurement error (ρ^ = −0.192), Guttman errors (ρ^ = −0.233), multivariate outliers (ρ^ = −0.254), and acquiescent responses (ρ^ = −0.078); the overall effect for extreme responses (ρ^ = −0.045) was not significant. Effect sizes were consistent across studies, modes of survey administsration, and different cognitive functioning domains, although some cognitive domain specificity was also observed.

Discussion
Lower-quality responses among respondents with lower cognitive abilities add random and systematic errors to survey measures, reducing the reliability, validity, and reproducibility of survey study results in aging research.
Heterogeneous Effects of Volunteering on Frailty in Later Life: A Panel Quantile Regression Approach
Authors: Han Sae Hwang , Park Narae 
Published: March 2024

Abstract

Objectives
Decades of research indicate that volunteering is associated with better health for the volunteer beyond the selection effects based on health. However, little is known about potential heterogeneity in health outcomes associated with volunteering in the context of good or poor health. This study addresses this gap by focusing on the frailty index (FI) to investigate the volunteering–health nexus across the population frailty distribution ranging from fit to frail.

Methods
Using nationally representative data from the Health and Retirement Study (person N = 34,986; 198,218 person-wave observations), we estimated unconditional quantile regression models with panel fixed effects to estimate changes in FI associated with changes in the share of volunteers in the population across the frailty distribution observed across the study period (1998–2020).

Results
Our findings demonstrated that the volunteering–FI association was heterogeneous across the frailty distribution. The association was the most potent at the higher end of the frailty distribution, suggesting that efforts to promote volunteering may yield greater benefits for older adults experiencing high levels of frailty.

Discussion
The current study findings provide unique and compelling evidence in support of earlier calls for considering volunteering as a public health intervention. The study findings are discussed in the context of population health outcomes and health disparities.
Two-Year Efficacy and Safety of Mirikizumab Following 104 Weeks of Continuous Treatment for Ulcerative Colitis: Results From the LUCENT-3 Open-Label Extension Study
Authors: Sands Bruce E , D’Haens Geert , Clemow David B , Irving Peter M , Johns Jordan T , Hunter Gibble Theresa , Abreu Maria T , Lee Scott , Hisamatsu Tadakazu , Kobayashi Taku , Dubinsky Marla C , Vermeire Severine , Siegel Corey A , Peyrin-Biroulet Laurent , Moses Richard E , Milata Joe , Arora Vipin , Panaccione Remo , Dignass Axel 
Published: March 2024

Abstract

Background
Mirikizumab, a p19-directed interleukin-23 monoclonal antibody, is efficacious in inducing clinical remission at week 12 (W12) and maintaining clinical remission at W52 in patients with moderately to severely active ulcerative colitis. Results are presented from the open-label extension study through W104.

Methods
Clinical, symptomatic, quality-of-life, and adverse event outcomes are reported for mirikizumab induction responders and extended induction responders, including biologic-failed patients, who entered LUCENT-3, with data shown for W52 maintenance responders or remitters. Discontinuations or missing data were handled by nonresponder imputation (NRI), modified NRI (mNRI), and observed case (OC).

Results
Among W52 mirikizumab responders, clinical response at W104 was 74.5%, 87.2%, and 96.7% and clinical remission was 54.0%, 62.8%, and 70.1% for NRI, mNRI, and OC, respectively. Among W52 mirikizumab remitters, clinical response at W104 was 76.6%, 89.0%, and 98.3% and clinical remission was 65.6%, 76.1%, and 84.2%. Using mNRI, remission rates at W104 for W52 clinical remitters were 74.7% corticosteroid-free, 79.5% endoscopic, 63.9% histologic-endoscopic mucosal remission, 85.9% symptomatic, 59.8% bowel urgency, 80.5% Inflammatory Bowel Disease Questionnaire (using NRI), 71.2% histologic-endoscopic mucosal improvement, and 77.5% bowel urgency improvement. Previous biologic-failed vs not-biologic-failed patient data were generally similar. Extended induction mNRI clinical response was 81.9%. Serious adverse events were reported in 5.2% of patients; 2.8% discontinued treatment due to adverse events.

Conclusions
Endoscopic, histologic, symptomatic, and quality-of-life outcomes support the long-term benefit of mirikizumab treatment up to 104 weeks in patients with ulcerative colitis, including biologic-failed patients, with no new safety concerns.
Instituting coronavirus disease 2019 testing: opportunities and challenges of molecular laboratory diagnosis in a Southern Nigerian teaching hospital
Authors: Osaigbovo Iriagbonse I , Igbarumah Isaac O , Obaseki Darlington E 
Published: March 2024

Abstract
The coronavirus disease 2019 pandemic emphasised the importance of laboratory preparedness, including molecular diagnostic capacity, in the control of infectious disease outbreaks. This article reflects on diagnostic capacity-building opportunities presented by the pandemic, the challenges experienced along the way and the lessons learned from the perspective of a university teaching hospital in Southern Nigeria. We advocate for these lessons to inform strategic planning for laboratory preparedness at subnational, national and continental levels.
What are the optimal pharmacokinetic/pharmacodynamic targets for β-lactamase inhibitors? A systematic review
Authors: Assefa Getnet M , Roberts Jason A , Mohammed Solomon A , Sime Fekade B 
Published: March 2024

Abstract

Background
Pharmacokinetic/pharmacodynamic (PK/PD) indices are widely used for the selection of optimum antibiotic doses. For β-lactam antibiotics, fT&gt;MIC, best relates antibiotic exposure to efficacy and is widely used to guide the dosing of β-lactam/β-lactamase inhibitor (BLI) combinations, often without considering any PK/PD exposure requirements for BLIs.

Objectives
This systematic review aimed to describe the PK/PD exposure requirements of BLIs for optimal microbiological efficacy when used in combination with β-lactam antibiotics.

Methods
Literature was searched online through PubMed, Embase, Web of Science, Scopus and Cochrane Library databases up to 5 June 2023. Studies that report the PK/PD index and threshold concentration of BLIs approved for clinical use were included. Narrative data synthesis was carried out to assimilate the available evidence.

Results
Twenty-three studies were included. The PK/PD index that described the efficacy of BLIs was fT&gt;CT for tazobactam, avibactam and clavulanic acid and fAUC0–24/MIC for relebactam and vaborbactam. The optimal magnitude of the PK/PD index is variable for each BLI based on the companion β-lactam antibiotics, type of bacteria and β-lactamase enzyme gene transcription levels.

Conclusions
The PK/PD index that describes the efficacy of BLIs and the exposure measure required for their efficacy is variable among inhibitors; as a result, it is difficult to make clear inference on what the optimum index is. Further PK/PD profiling of BLI, using preclinical infection models that simulate the anticipated mode(s) of clinical use, is warranted to streamline the exposure targets for use in the optimization of dosing regimens.