bluuebunny/crossref_metadata_2025_split huggingface dataset:
1D, 2D and 3D Coordination Polymers of Aromatic Carboxylate TbIII: Structure, Thermolysis Kinetics and Fluorescence
Authors: Zhou Ying‐Xia , Shen Xiao‐Qing , Du Chen‐Xia , Wu Ben‐Lai , Zhang Hong‐Yun 
Published: August 2008

AbstractReactions of TbCl3·6H2O with aromatic acids, namely, pyridine‐2,3‐dicarboxylic acid (H2pda), isophthalic acid (H2ipa) and isonicotinic acid (Hina) gave rise to three new coordination polymers {[Tb(pda)(Hpda)]·3H2O}n (1), {[KTb(ipa)2(H2O)3(μ‐H2O)]·2H2O}n (2) and [Tb(ina)3(H2O)2]n (3), respectively. Complex 1 constructed by eight‐coordinate TbIII nodes connected with completely and half‐deprotonated pda and Hpda spacers is a novel 3D metal–organic architecture with nanosized hexagonal 1D channels hosting guest water, whereas complex 2 is a 2D heterometal sheet built by completely deprotonated ipa spacers bridging eight‐coordinate KI and nine‐coordinate TbIII. As for 3, deprotonated monoacid ina anions link eight‐coordinate TbIII centres into a 1D double‐chain structure. As excited at 320 nm, complexes 1–3 all display a serial of emissions centred at about 486, 545, 582 and 620 nm, which is assigned to the characteristic 5D4 → 7Fj (j = 6; 5; 4; 3) electronic transitions of TbIII. The overall fluorescence nature of 1–3 is extremely alike, but their fluorescence intensity and lifetime are affected by the architectures. Very interestingly, the fluorescence intensity of 2, especially emitting at 545 nm, is largely enhanced owing to the coordination of alkali metal KI in the TbIII–carboxylate network. Furthermore, thermal behaviours of 1–3 under a nitrogen atmosphere as well as the thermolysis nonisothermal kinetics of 2 are researched.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
FRET in Orthogonally Arranged Chromophores
Authors: Langhals Heinz , Poxleitner Simon , Krotz Oswald , Pust Tim , Walter Andreas 
Published: August 2008

AbstractPerylene and benzoperylene carboxylic imides were arranged to form a bichromophoric dye with orthogonal electronic transition moments. Thus, exciton interactions between the two chromophores could be excluded, in spite of their proximity. However, quantitative Förster‐type energy transfer proceeds between the chromophores indicated by a fluorescence quantum yield close to unity even with hypsochromic excitation. Applications are discussed. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Synthesis of Substituted Oxazoles from N‐Acyl‐β‐hydroxyamino Acid Derivatives
Authors: Ferreira Paula M. T. , Monteiro Luís S. , Pereira Goreti 
Published: August 2008

AbstractSeveral N‐acyl‐β‐hydroxyamino acids were prepared and treated with di‐tert‐butyl dicarbonate in the presence of 4‐(dimethylamino)pyridine, followed by treatment with N,N,N′,N′‐tetramethylguanidine to give the corresponding N‐acyldehydroamino acids in good to high yields. These were then treated with I2/K2CO3 followed by 1,8‐diazabicyclo[5.4.0]undec‐7‐ene. The methyl esters of N‐acyldehydroaminobutyric acid gave the corresponding substituted oxazoles in good to high yields. The N‐acyldehydrophenylalanines gave 5‐phenyloxazole derivatives in low to moderate yields together with β‐iododehydrophenylalanines. Under the same conditions, N‐acyldehydroalanines failed to give the corresponding oxazoles. However, when the reaction was carried out in the absence of DBU, it was possible to isolate the β,β‐diiododehydroalanine derivatives. Although the reason for the different reactivities of the N‐acyldehydroamino acids is not completely clear to us, cyclic voltammetry studies showed that the less‐reactive derivatives have higher reduction potentials. This suggests that the double bonds in dehydroaminobutyric acid derivatives are more susceptible to electrophilic attack by iodine.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Pd(OAc)2/p‐Benzoquinone‐Catalyzed Anaerobic Electrooxidative Homocoupling of Arylboronic Acids, Arylboronates and Aryltrifluoroborates in DMF and/or Water
Authors: Amatore Christian , Cammoun Chama , Jutand Anny 
Published: August 2008

AbstractA new anaerobic electrooxidative homocoupling of arylboronic acids, arylboronates and aryltrifluoroborates was developed in the presence of catalytic amounts of Pd(OAc)2 and p‐benzoquinone, which serves as a redox mediator for the oxidation of transient Pd0 to the active PdII species. The homocoupling was performed in DMF, DMF/water or in pure water. This electrochemical process avoids the use of a stoichiometric amount of chemical oxidants and subsequent formation of co‐ and by‐products.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Making plans for healthy diet: The role of motivation and action orientation
Authors: De Ridder Denise , de Wit John , Adriaanse Marieke A. 
Published: August 2008

AbstractThe main objective of the present study was to examine the role of motivation and action orientation in forming spontaneous (i.e., without specific instruction or manipulation) implementation intentions for a healthy diet goal. We hypothesized that (1) the adoption of a diet goal would be determined by (either intrinsic or extrinsic) motivation only whereas, (2) forming implementation intentions would be determined by intrinsic motivation and (either low or high) action orientation. These hypotheses were addressed in a sample of 142 normal weight subjects who were concerned about their dietary habits. Primary outcomes were goal intentions and implementation intentions. Our hypothesis regarding the prediction of goal intentions was confirmed whereas results relating to the prediction of implementation intentions demonstrated that intrinsic motivation and low (but not high) action orientation proved significant predictors of intentions to implement a healthy diet goal. These findings suggest that self‐regulatory skills as assessed by the concept of action orientation may relate to short‐term strategies of initiating behavior change only. Copyright © 2008 John Wiley & Sons, Ltd.
Anti‐Interferent Properties of Oxidized Nickel Based on Layered Double Hydroxide in Glucose Amperometric Biosensors
Authors: Scavetta Erika , Guadagnini Lorella , Mignani Adriana , Tonelli Domenica 
Published: August 2008

AbstractAn amperometric biosensor based on Pt electrodes modified with a thin film of a Ni, Al layered double hydroxide (LDH), submitted to a preliminary oxidative treatment in order to have the nickel centers at the oxidation state +4, and glucose oxidase (GOx) is presented. The oxidized LDH acts both as a system to support the enzyme and as a barrier to anions since it acquires an overall negative charge, as demonstrated by electrochemical impedance spectroscopy. Even if the biosensor response is due to the detection of H2O2 at anodic potentials, glucose can be accurately determined in the presence of ascorbic acid or other interferences, commonly present in real matrices in anionic form, since they can not reach the electrode surface. The effectiveness of the developed biosensor has been demonstrated by measuring glucose in samples of fruit juices containing ascorbic acid at high levels.
Hypoosmotic swelling affects zinc homeostasis in cultured rat astrocytes
Authors: Kruczek Caroline , Görg Boris , Keitel Verena , Pirev Elvis , Kröncke Klaus D. , Schliess Freimut , Häussinger Dieter 
Published: August 2008

AbstractAstrocyte swelling is observed in different types of brain injury including hepatic encephalopathy (HE). This study investigates the role of astrocyte swelling on Zn2+ homeostasis in hypoosmotically treated astrocytes by using the Zn2+ indicators Newport‐Green, Zinquin, and RhodZin‐3. Hypoosmolarity (205 mosmol/L) led to a persistent increase of the intracellular “free” Zn2+ concentration [Zn2+]i within 15 min, which was reversible after reinstitution of normoosmolarity (305 mosmol/L). The hypoosmotic [Zn2+]i increase was abolished in the presence of the Zn2+ chelator TPEN, the NMDA receptor antagonists MK‐801 and AP5, the antioxidant epigallocatechin gallate, and the nitric oxide synthase inhibitors L‐NMMA and TRIM. Hypoosmolarity triggered nuclear accumulation of the metal response element‐binding transcription factor MTF‐1 and the specificity protein Sp1 and expression of the mRNAs encoding metallothionein and the Sp1‐regulated peripheral‐type benzodiazepine receptor (PBR). These effects were abolished by the Zn2+ chelator TPEN. The data suggest that astrocyte swelling affects gene expression by modulation of [Zn2+]i. Whereas Zn2+‐dependent upregulation of metallothionein may help to counteract excessive astrocyte swelling and production of reactive oxygen and nitrogen oxide species, stimulation of PBR expression may augment HE development. © 2008 Wiley‐Liss, Inc.
Stress perception and commuting
Authors: Gottholmseder Georg , Nowotny Klaus , Pruckner Gerald J. , Theurl Engelbert 
Published: August 2008

AbstractThis paper analyzes the determinants of the perceived stress level of workers with a special focus on the effects of commuting, while controlling for personal and work‐related characteristics. Using ordered logistic regression we find that several dimensions of the commuting situation, such as impedance, control and predictability of commuting, significantly influence the perceived stress level. Therefore, stress and stress‐related health problems should be taken into consideration when analyzing the economic costs of commuting. Copyright © 2008 John Wiley & Sons, Ltd.
Investing time in health: do socioeconomically disadvantaged patients spend more or less extra time on diabetes self‐care?
Authors: Ettner Susan L. , Cadwell Betsy L. , Russell Louise B. , Brown Arleen , Karter Andrew J. , Safford Monika , Mangione Carol , Beckles Gloria , Herman William H. , Thompson Theodore J. ,   and The TRIAD Study Group
Published: August 2008

AbstractBackground: Research on self‐care for chronic disease has not examined time requirements. Translating Research into Action for Diabetes (TRIAD), a multi‐site study of managed care patients with diabetes, is among the first to assess self‐care time.Objective: To examine associations between socioeconomic position and extra time patients spend on foot care, shopping/cooking, and exercise due to diabetes.Data: Eleven thousand nine hundred and twenty‐seven patient surveys from 2000 to 2001.Methods: Bayesian two‐part models were used to estimate associations of self‐reported extra time spent on self‐care with race/ethnicity, education, and income, controlling for demographic and clinical characteristics.Results: Proportions of patients spending no extra time on foot care, shopping/cooking, and exercise were, respectively, 37, 52, and 31%. Extra time spent on foot care and shopping/cooking was greater among racial/ethnic minorities, less‐educated and lower‐income patients. For example, African‐Americans were about 10 percentage points more likely to report spending extra time on foot care than whites and extra time spent was about 3 min more per day.Discussion: Extra time spent on self‐care was greater for socioeconomically disadvantaged patients than for advantaged patients, perhaps because their perceived opportunity cost of time is lower or they cannot afford substitutes. Our findings suggest that poorly controlled diabetes risk factors among disadvantaged populations may not be attributable to self‐care practices. Copyright © 2008 John Wiley & Sons, Ltd.
Four potential biomarkers as prognostic factors in stage III serous ovarian adenocarcinomas
Authors: Partheen Karolina , Levan Kristina , Österberg Lovisa , Claesson Ingela , Fallenius Ghita , Sundfeldt Karin , Horvath György 
Published: August 2008

AbstractThe mortality rate for patients with ovarian carcinomas is high and the available prognostic factors are insufficient. The use of biomarkers may contribute to better prediction and survival for these patients. We aimed to study the gene and protein expressions for 7 potential biomarkers, to determine if it is possible to use them as prognostic factors. Genes selected from our previous microarray analysis (2006), CLU, ITGB3, TACC1, MUC5B, CAPG, PRAME and TROAP, were analyzed in 19 of the tumors with quantitative real‐time polymerase chain reaction (QPCR). We found that CLU and ITGB3 were more expressed in tumors from survivors and PRAME and CAPG were more expressed in tumors from deceased patients. None of the other 3 genes were significantly differently expressed. The protein expressions of CLU, ITGB3, PRAME and CAPG were analyzed in 43 of the tumors with western blot for semiquantitative analysis. We established that the mRNA and protein expressions correlated and that all 4 proteins were significantly differently expressed. Further, immunohistochemistry (IHC) was used to localize the expression of the proteins in the tumor samples. According to our results, the 4 biomarkers CLU, ITGB3, PRAME and CAPG may be used as prognostic factors for patients with stage III serous ovarian adenocarcinomas. © 2008 Wiley‐Liss, Inc.
Loss of Drop1 expression already at early tumor stages in a wide range of human carcinomas
Authors: Marmé Alexander , Zimmermann Hans‐Peter , Moldenhauer Gerhard , Schorpp‐Kistner Marina , Müller Claudia , Keberlein Olga , Giersch Antje , Kretschmer Jürgen , Seib Brigitte , Spiess Eberhard , Hunziker Andreas , Merchán Faustino , Möller Peter , Hahn Uwe , Kurek Raffael , Marmé Frederik , Bastert Gunther , Wallwiener Diethelm , Ponstingl Herwig 
Published: August 2008

AbstractIn a study on gene deregulation in ovarian carcinoma we found a mRNA coding for a 350 kDa protein, Drop1, to be downregulated 20‐ to 180‐fold in the majority of ovarian and mammary carcinomas. The mRNA is encoded by a set of exons in the 5′ region of the SYNE1 gene. Immunohistochemical staining for Drop1 protein by a specific monoclonal antibody corresponds to the pattern seen for the mRNA. cDNA arrays of matched pairs of tumor and normal tissue and in situ hybridizations confirmed the drastic loss of Drop1 mRNA as a common feature in uterus, cervix, kidney, lung, thyroid and pancreas carcinomas, already at early tumor stages and in all metastases. Two‐hybrid studies suggest a role of this deficiency in the malignant progression of epithelial tumors. © 2008 Wiley‐Liss, Inc.
Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding
Authors: Theodoratou Evropi , Farrington Susan M. , Tenesa Albert , McNeill Geraldine , Cetnarskyj Roseanne , Barnetson Rebecca A. , Porteous Mary E. , Dunlop Malcolm G. , Campbell Harry 
Published: August 2008

AbstractVitamin D has anticarcinogenic properties and might influence colorectal cancer (CRC) risk, but the epidemiological evidence is inconsistent. Many mechanisms of action for vitamin D have been proposed, with some of them initiating via its binding to the vitamin D receptor (VDR). Using a large Scottish case–control study, we investigated (i) main associations between CRC, vitamin D and calcium dietary intake and 4 VDR single nucleotide polymorphisms (rs10735810, rs1544410, rs11568820, rs7975232) and (ii) interaction associations between the VDR variants, vitamin D and calcium intakes. Inverse and dose‐dependent associations were found between CRC risk, dietary [Odds ratio (OR) = 0.77, 95% confidence intervals (CI) 0.63, 0.92, p‐trend = 0.012] and total vitamin D (OR = 0.80, 95% CI 0.65, 0.98, p‐trend = 0.014) intake in multivariable‐adjusted logistic regression models, whereas neither calcium intake nor any of the VDR variants were associated with CRC. Additionally, we observed statistically significant interactions (case–control, case‐only designs) between vitamin D and calcium intake and rs10735810 (p‐interaction 0.02, 0.006, respectively). We conducted meta‐analyses of cohort, case–control and serum studies that also showed an inverse association between dietary vitamin D intake and CRC (serum studies: combined OR = 0.70, 95% CI 0.56, 0.87). The evidence of interaction we report here further supports the inverse association between vitamin D mediated through binding to the VDR. © 2008 Wiley‐Liss, Inc.
Highly sensitive detection of early‐stage pancreatic cancer by multimodal near‐infrared molecular imaging in living mice
Authors: von Burstin Johannes , Eser Stefan , Seidler Barbara , Meining Alexander , Bajbouj Monther , Mages Jörg , Lang Roland , Kind Alexander J. , Schnieke Angelika E. , Schmid Roland M. , Schneider Günter , Saur Dieter 
Published: August 2008

AbstractPancreatic cancer is a serious disease with poor patient outcome, often as a consequence of late diagnosis in advanced stages. This is in large part due to the lack of diagnostic tools for early detection. To address this deficiency, we have investigated novel molecular near‐infrared fluorescent (NIRF) in vivo imaging techniques in clinically relevant mouse models of pancreatic cancer. Genome wide gene expression profiling was used to identify cathepsin cystein proteases and matrix metalloproteinases (MMP) as targets for NIRF imaging. Appropriate protease activatable probes were evaluated for detection of early‐stage pancreatic cancer in mice with orthotopically implanted pancreatic cancer cell lines. Mice with pancreatitis served as controls. Whole body in vivo NIRF imaging using activatable cathepsin sensitive probes specifically detected pancreatic tumors as small as 1–2 mm diameter. Imaging of MMP activity demonstrated high specificity for MMP positive tumors. Intravital flexible confocal fluorescence lasermicroscopy of protease activity enabled specific detection of pancreatic tumors at the cellular level. Importantly, topical application of NIRF‐probes markedly reduced background without altering signal intensity. Taken together, macroscopic and confocal lasermicroscopic molecular in vivo imaging of protease activity is highly sensitive, specific and allows discrimination between normal pancreatic tissue, inflammation and pancreatic cancer. Translation of this approach to the clinic could significantly improve endoscopic and laparoscopic detection of early‐stage pancreatic cancer. © 2008 Wiley‐Liss, Inc.
Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans
Authors: Chang Jeffrey S. , Wrensch Margaret R. , Hansen Helen M. , Sison Jennette D. , Aldrich Melinda C. , Quesenberry Charles P. , Seldin Michael F. , Kelsey Karl T. , Kittles Rick A. , Silva Gabriel , Wiencke John K. 
Published: August 2008

AbstractFew studies on the association between nucleotide excision repair (NER) variants and lung cancer risk have included Latinos and African Americans. We examine variants in 6 NER genes (ERCC2, ERCC4, ERCC5, LIG1, RAD23B and XPC) in association with primary lung cancer risk among 113 Latino and 255 African American subjects newly diagnosed with primary lung cancer from 1998 to 2003 in the San Francisco Bay Area and 579 healthy controls (299 Latinos and 280 African Americans). Individual single nucleotide polymorphism and haplotype analyses, multifactor dimensionality reduction (MDR) and principal components analysis (PCA) were performed to assess the association between 6 genes in the NER pathway and lung cancer risk. Among Latinos, ERCC2 haplotype CGA (rs238406, rs11878644, rs6966) was associated with reduced lung cancer risk [odds ratio (OR) of 0.65 and 95% confidence interval (CI): 0.44–0.97], especially among nonsmokers (OR = 0.29; 95% CI: 0.12–0.67). From MDR analysis, in Latinos, smoking and 3 SNPs (ERCC2 rs171140, ERCC5 rs17655 and LIG1 rs20581) together had a prediction accuracy of 67.4% (p = 0.001) for lung cancer. Among African Americans, His/His genotype of ERCC5 His1104Asp (rs17655) was associated with increased lung cancer risk (OR = 1.78; 95% CI: 1.09–2.91), and LIG1 haplotype GGGAA (rs20581, rs156641, rs3730931, rs20579 and rs439132) was associated with reduced lung cancer risk (OR = 0.61; 95% CI: 0.42–0.88). Our study suggests different elements of the NER pathway may be important in the different ethnic groups resulting either from different linkage relationship, genetic backgrounds and/or exposure histories. © 2008 Wiley‐Liss, Inc.
Validation of a novel biomarker for acute axonal injury in experimental autoimmune encephalomyelitis
Authors: Gresle Melissa M. , Shaw Gerry , Jarrott Bevyn , Alexandrou Estella N. , Friedhuber Anna , Kilpatrick Trevor J. , Butzkueven Helmut 
Published: August 2008

AbstractIn multiple sclerosis, inflammatory axonal injury is a key pathological mechanism responsible for the development of progressive neurological dysfunction. The injured axon represents a therapeutic target in this disease; however, therapeutic trials of neuroprotective candidates will initially require preclinical testing in an animal model of inflammatory axonal injury and subsequently the development of a reliable paraclinical measure of axonal degeneration in humans. In the present study, we demonstrate the validity of serum phosphorylated neurofilament H (pNF‐H) as a marker of axonal injury in murine experimental autoimmune encephalomyelitis (EAE). At the time of maximum disease severity (EAE day 22), the average serum pNF‐H level reached 5.7 ng/ml, correlating significantly with the EAE paraplegia score (r = 0.75, P < 0.001). On average, 40% of axons in the spinal cord were lost in EAE, and serum pNF‐H levels were highly correlated with axon loss (r = 0.8, P < 0.001). Axonal injury was a severe and acute event, insofar as serum pNF‐H levels were not significantly elevated at early (EAE day 12) or late (EAE days 35 and 50) disease time points. Our results demonstrate that acute inflammatory axonal injury is a pathological feature of murine MOG35–55 EAE, indicating that this model may mirror the acute pathological events in active multiple sclerosis lesions. Furthermore, we have validated the serum pNF‐H assay as an unbiased measurement of axonal injury in EAE, facilitating rapid screening of potential neuroprotective therapies in this model. © 2008 Wiley‐Liss, Inc.
Retinal pigment epithelial cells promote spatial reorganization and differentiation of retina photoreceptors
Authors: German Olga L. , Buzzi Edgardo , Rotstein Nora P. , Rodríguez‐Boulan Enrique , Politi Luis E. 
Published: August 2008

AbstractRetina differentiation involves the acquisition of a precise layered arrangement, with RPE cells in the first layer in intimate contact with photoreceptors in the second layer. Here, we developed an in vitro coculture model, to test the hypothesis that RPE cells play a pivotal role in organizing the spatial structure of the retina. We cocultured rat retinal neurons with ARPE‐19 epithelial cells under various experimental conditions. Strikingly, when seeded over RPE cells, photoreceptors attached to their apical surfaces and proceeded with their development, including the increased synthesis of rhodopsin. Conversely, when we seeded RPE cells over neurons, the RPE cells rapidly detached photoreceptors from their substrata and positioned themselves underneath, thus restoring the normal in vivo arrangement. Treatment with the metalloproteinase inhibitor TIMP‐1 blocked this reorganization, suggesting the involvement of metalloproteinases in this process. Reorganization was highly selective for photoreceptors because 98% of photoreceptors but very few amacrine neurons were found to redistribute on top of RPE cells. Interestingly, RPE cells were much more efficient than other epithelial or nonepithelial cells in promoting this reorganization. RPE cells also promoted the growth of photoreceptor axons away from them. An additional factor that contributed to the distal arrangement of photoreceptor axons was the migration of photoreceptor cell bodies along their own neurites toward the RPE cells. Our results demonstrate that RPE and photoreceptor cells interact in vitro in very specific ways. They also show that in vitro studies may provide important insights into the process of pattern formation in the retina. © 2008 Wiley‐Liss, Inc.