bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is it possible to start the treatment based on immediate cytologic evaluation of core needle biopsy of the spinal lesions?
Authors: Rezanko Turkan , Sucu Hasan Kamil , Akkalp Asli , Tunakan Mine , Sari Aysegul , Minoglu Mustafa , Bolat Betul 
Published: June 2008

AbstractCore needle biopsy is widely used to diagnose spinal lesions. Final histopathological report of the specimen usually can be given after several days. These several days delay may prevent early treatment in some patients. Our aim was to investigate if treatment of spinal lesions could be started according to the immediate cytologic evaluation of the core needle biopsy. The cytological materials of the 213 core needle spinal biopsy were prepared immediately after biopsy procedure. Of these biopsies, only 101 core needle biopsy had a final diagnosis which formed the backbone of the current study. Cytological materials of these cases were compared with both histopathologic results of the core biopsy and with final diagnosis obtained by open surgery or clinical follow up. According to final diagnoses 40 patients had infections, 59 patients had neoplasms and 2 patients had no pathology. When the diagnosis that determines the treatment is considered, the overall success rates (positive predictive value:PPV) of cytology and histology were 0.65 and 0.76 respectively. Moreover when the specific diagnosis were analyzed separetely in the subgroups of tuberculous infection, lymphoma and plasmacytoma; PPV of both cytological and histological assessments was 1.00. In spinal metastasis, PPV was 0.97 for cytology and 1.00 for histology. Rapid cytologic interpretation of core needle biopsy material is a useful and reliable tool to determine the spinal lesions which require urgent treatment. When the cytological specimen reveals the diagnosis of spinal metastasis, lymphoma, plasmacytoma or tuberculosis, the treatment may be started without waiting the result of the histological examination. Diagn. Cytopathol. 2008;36:478–484. © 2008 Wiley‐Liss, Inc.
Effects of a cognitive dissonance‐based eating disorder prevention program are similar for Asian American, Hispanic, and White participants
Authors: Rodriguez Rosalía , Marchand Erica , Ng Janet , Stice Eric 
Published: June 2008

AbstractObjective:This study explored the effects of participating in a dissonance‐based eating disorder prevention program on changes in thin ideal internalization, body dissatisfaction, and eating symptoms among White, Asian American, and Hispanic participants.Method:Participants were (n = 394), 13 to 20‐year‐old adolescent girls and young women who reported being White (n = 311), Hispanic/Latina (n = 61), or Asian‐American/Hawaiian/Pacific Islander (n = 33). The current study used data drawn from the pre‐ and post assessments of an efficacy trial and an effectiveness trial of this eating disorder prevention program.Results:The intervention reduced disordered eating behaviors and eating disorder risk factors for all three ethnic groups at post‐intervention assessment; there was no evidence of significantly stronger effects in any particular ethnic group.Conclusion:Results suggest that a cognitive dissonance‐based prevention program for eating disorders may be equally effective for Asian American, Hispanic, and White adolescent women. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2008
New High Temperature Polymer Electrolyte Membranes. Influence of the Chemical Structure on their Properties
Authors: Gourdoupi N. , Papadimitriou K. , Neophytides S. , Kallitsis J. K. 
Published: June 2008

AbstractNew polymer electrolytes based on aromatic polyethers bearing main chain pyridine groups have been synthesised. They possess good mechanical properties, high thermal and oxidative stability and can be used as electrolytes for high temperature PEM fuel cells. A study of the influence of the chemical structure on the properties of these materials with respect to their ability to be used in high temperature PEM fuel cells was made, while a blend of the current reported polymers is tested in single cell giving encouraging preliminary results.
Fine‐needle aspiration cytology in a regional head and neck cancer center: Comparison with a systematic review and meta‐analysis
Authors: Tandon Sankalap , Shahab Riad , Benton James I. , Ghosh Samit K. , Sheard Jonathan , Jones Terry M. 
Published: June 2008

AbstractBackgroundFine‐needle aspiration cytology (FNAC) is used to diagnose masses presenting in the head and neck region. No systematic review of FNAC in this group has yet been performed.MethodsA systematic review of the published literature and meta‐analysis of data extracted from the included studies were compared with a 10‐year review of head and neck FNAC from our institution.ResultsSystematic review identified 30 studies; 3459 FNAC aspirates from all head and neck sites were included. Overall results were as follows: sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) were 89.6%, 96.5%, 93.1%, 96.2%, and 90.3%, respectively. Two thousand seven hundred two head and neck aspirates were included in our institutional review. Sensitivity, specificity, PPV, NPV, and accuracy were 89.5%, 98.5%, 97.3%, 94.0%, and 95.1%, respectively.ConclusionMeta‐analysis and comparative systematic review confirm that FNAC is highly effective in the diagnosis of head and neck masses, with some limitations. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Entorhinal theta phase precession sculpts dentate gyrus place fields
Authors: Molter Colin , Yamaguchi Yoko 
Published: June 2008

AbstractIt is known that the hippocampus facilitates memory formation and spatial representation and that hippocampal place cells establish spatial representations with firing activity modulated in terms of ‘theta phase precession’. Clarifying how these spatial and temporal activities interact to process information is essential for a more coherent understanding of the way the hippocampus works. Recently, it has been reported that layer II entorhinal cortical cells, which mediate the majority of the cortical inputs to the dentate gyrus (DG), located at the gate of the hippocampus, fire with theta phase precession according to a grid‐like pattern. Here we hypothesize that the temporal code of entorhinal grid neurons firing with theta phase precession provides selectivity in input integration of dentate neurons to support the emergence of place fields. Our large‐scale network model analyses demonstrated that, by assuming coincidence detection properties of dentate neurons, grid fields are reliably transformed to place fields in a novel environment. Furthermore, global remapping of place fields in sequential experiences of environments can be obtained in agreement with known experimental observation. These findings indicate a critical role of temporal coding for space computation in the entorhinal‐hippocampal system. © 2008 Wiley‐Liss, Inc.
Why is the meaning of a sentence better remembered than its form? An fMRI study on the role of novelty‐encoding processes
Authors: Poppenk J. , Walia G. , McIntosh A.R. , Joanisse M.F. , Klein D. , Köhler S. 
Published: June 2008

AbstractEpisodic memory is based primarily on meaning. This is behaviorally well documented in studies on memory for prose, in which the meaning of novel sentences is typically well remembered but information pertaining to exact wording and syntax is not. The neural basis of this ‘verbatim effect’ is poorly understood. In the current fMRI study, we manipulated the novelty of sentences at different levels to test whether medial temporal lobe (MTL) regions that are known to play a critical role in verbal episodic encoding would respond preferentially to the novelty of sentence meaning. Fifteen participants were pre‐familiarized with auditory sentences describing unique episodes. During scanning, they encountered sentences that were old, that contained a change in (i.e., were novel in terms of) syntactic relationships, that contained a change in semantic relationships, or that described an entirely novel episode. Subsequently, participants performed a recognition memory test for the different types of novel information encountered. Behavioral data confirmed the typical verbatim effect. Analyses of fMRI data revealed differential MTL activation in the left hippocampus and entorhinal cortex with a response profile across conditions that paralleled the behavioral results; the identified region responded selectively to those conditions that contained semantic novelty. Other regions, by contrast, showed a novelty response that did not share this selectivity. Our findings suggest that the verbatim effect can be linked to hippocampally‐based novelty‐assessment processes that operate based on semantic relationships. © 2008 Wiley‐Liss, Inc.
Rain event properties in nature and in rainfall simulation experiments: a comparative review with recommendations for increasingly systematic study and reporting
Authors: Dunkerley David 
Published: June 2008

AbstractIn hydrology and geomorphology, less attention has been paid to raineventproperties such as duration, mean and peak rain rate than torainproperties such as drop size or kinetic energy. A literature review shows a lack of correspondence between natural and simulated rain events. For example, 26 studies that report event statistics from substantial records of natural rain reveal a mean rain rate of just 3·47 mm h−1(s.d. 2·38 mm h−1). In 17 comparable studies dealing with extreme rain rates including events in cyclonic, tropical convective, and typhoon conditions, a mean maximum rain rate (either hourly or mean event rain rate) of 86·3 mm h−1(s.d. 57·7 mm h−1) is demonstrated. However, 49 studies using rainfall simulation involve a mean maximum rain rate of 103·1 mm h−1(s.d. 81·3 mm h−1), often sustained for > 1 h, exceeding even than of extreme rain events, and nearly 30 times the mean rain rate in ordinary, non‐exceptional, rain events. Thus rainfall simulation is often biased toward high rain rates, and many of the rates employed (in several instances exceeding 150 mm h−1) appear to have limited relevance to ordinary field conditions. Generally, simulations should resemble natural rain events in each study region. Attention is also drawn to the raindrop arrival rate at the surface. In natural rain, this is known to vary from < 100 m−2s−1to > 5000 m−2s−1. Arrival rate may need to be added to the list of parameters that must be reproduced realistically in rainfall simulation studies. Copyright © 2008 John Wiley & Sons, Ltd.
Monotonic trend and abrupt changes for major climate variables in the headwater catchment of the Yellow River basin
Authors: Zhao F. F. , Xu Z. X. , Huang J. X. , Li J. Y. 
Published: June 2008

AbstractOn the basis of the mean air temperature, precipitation, sunshine duration and pan evaporation at 23 meteorological stations in the headwater catchment of the Yellow River basin from 1960 to 2001, the long‐term monotonic trend and abrupt changes for major climate variables have been investigated. The plausible monotonic trend of annual climatic time series are detected using a non‐parametric method. The abrupt changes have been investigated in terms of a 5 year moving averaged annual series, using the moving t‐test (MTT) method, Yamamoto method and Mann–Kendall method. The results showed that the annual air temperature has increased by 0·80 °C in the headwater catchment of the Yellow River basin during the past 42 years. One obvious cold period and one warm period were detected. The warmest centre was located in the northern part of the basin. The long‐term trend for annual precipitation was not significant during the same period, but a dry tendency was detected. According to the Kendall slope values, the declining centre for annual precipitation was located in the eastern part and the centre of the study area. The long‐term monotonic trend for annual sunshine duration and pan evaporation were negative. The average Kendall slopes are − 29·96 h/10 yr and − 39·63 mm/10 yr, respectively. The tests for abrupt changes using MTT and Yamamoto methods show similar results. Abrupt changes occurred in the mid 1980s for temperature, in the late 1980s for precipitation and in the early 1980s for sunshine duration and pan evaporation. It can be seen that the abrupt changes really happened in the 1980s for the climate variables. Different results are shown using the Mann–Kendall method. Both the abrupt changes of temperature and precipitation took place in the early 1990s, and that of pan evaporation occurred in the 1960s. The only abrupt change in sunshine duration happened during the similar period (in the 1980s) with the results detected by the MTT and Yamamoto methods. The abrupt changes which occurred in the 1990s and 1960s are not detectable using the MTT and Yamamoto methods because of the data limitation. However, the results tested by the MTT and Yamamoto methods exhibited great consistency. Some of the reasons may be due to the similar principles for these two methods. Different methods testing the abrupt climatic changes have their own merits and limitations and should be compared based on their own assumption and applicable conditions when they are used. Copyright © 2008 John Wiley & Sons, Ltd.
A hybrid protein comprising ATF domain of pro‐UK and VAS, an angiogenesis inhibitor, is a potent candidate for targeted cancer therapy
Authors: Sun Qiming , Xu Qian , Dong Xiangbai , Cao Lin , Huang Xiaofeng , Hu Qingang , Hua Zi‐Chun 
Published: June 2008

AbstractDirectional and controllable degradation of extracellular matrix mediated by the uPA‐uPA receptor (uPAR) system is ubiquitously implicated in tumor establishment, invasion and metastasis. Targeting the excessive activation of this system as well as the proliferation of the tumor vascular endothelial cell would be expected to prevent tumor neovasculature and halt the tumor development. In this study, we created a fusion protein (ALV), comprising the aminoterminal fragment (ATF) of urokinase and VAS, the antiangiogenic functional domain of vasostatin. The antitumor activity of this hybrid molecule was evaluated with both in vitro and in vivo experiments. Cell adhesion and motility assays demonstrated that ALV, owing to its ATF moiety, could interact with uPAR on the tumor cell surface with high affinity and specificity, and thereby might competitively inhibit the plasmin activation by localized urokinase and contribute to the suppression of tumor invasion. These results and speculations were validated by zymography assay and Matrigel invasion assay. In addition, ALV exhibited an improved inhibitory efficacy against endothelial cell (EC) proliferation and capillary vessel formation in a 3D angiogenesis model, proving that ATF and VAS, when fused into a chimeric molecule, cooperatively inhibited angiogenesis by targeting both the interaction of uPA and uPAR on cell surface (by ATF) and EC proliferation (mainly by VAS). Animal model confirmed that, at the same molar dose, ALV produced significantly higher therapeutic benefit than VAS and ATF in terms of tumor growth delay and mice survival prolongation. Conclusively coupling VAS with the uPAR ligand ATF resulted in an improved antineoplastic activity, which may show a novel avenue for the design of tumor therapeutic drugs. © 2008 Wiley‐Liss, Inc.
Lung, liver and bone cancer mortality in Mayak workers
Authors: Sokolnikov Mikhail E. , Gilbert Ethel S. , Preston Dale L. , Ron Elaine , Shilnikova Natalia S. , Khokhryakov Victor V. , Vasilenko Evgeny K. , Koshurnikova Nina A. 
Published: June 2008

AbstractWorkers at the Mayak nuclear facility in the Russian Federation offer the only adequate human data for evaluating cancer risks from exposure to plutonium. Risks of mortality from cancers of the lung, liver and bone, the organs receiving the largest doses from plutonium, were evaluated in a cohort of 17,740 workers initially hired 1948‐1972 using, for the first time, recently improved individual organ dose estimates. Excess relative risk (ERR) models were used to evaluate risks as functions of internal (plutonium) dose, external (primarily gamma) dose, gender, attained age and smoking. By December 31, 2003, 681 lung cancer deaths, 75 liver cancer deaths and 30 bone cancer deaths had occurred. Of these 786 deaths, 239 (30%) were attributed to plutonium exposure. Significant plutonium dose‐response relationships (p < 0.001) were observed for all 3 endpoints, with lung and liver cancer risks reasonably described by linear functions. At attained age 60, the ERRs per Gy for lung cancer were 7.1 for males and 15 for females; the averaged‐attained age ERRs for liver cancer were 2.6 and 29 for males and females, respectively; those for bone cancer were 0.76 and 3.4. This study is the first to present and compare dose‐response analyses for cancers of all 3 organs. The unique Mayak cohort with its high exposures and well characterized doses has allowed quantification of the plutonium dose‐response for lung, liver and bone cancer risks based on direct human data. These results will play an important role in plutonium risk assessment. Published 2008 Wiley‐Liss, Inc.
Retracted: TW‐37, a small‐molecule inhibitor of Bcl‐2, inhibits cell growth and invasion in pancreatic cancer
Authors: Wang Zhiwei , Song Wen , Aboukameel Amro , Mohammad Mussop , Wang Guoping , Banerjee Sanjeev , Kong Dejuan , Wang Shaomeng , Sarkar Fazlul H. , Mohammad Ramzi M. 
Published: June 2008

AbstractThis article has been retracted at the request of: Editor‐in‐Chief and Author‘TW‐37, a small‐molecule inhibitor of Bcl‐2, inhibits cell growth and invasion in pancreatic cancer’ by Wang, Z., Song, W., Aboukameel, A., Mohammad, M., Wang, G., Banerjee, S., Kong, D., Wang, S., Sarkar, F. H. and Mohammad, R. M.The above article, published online on 4 June 2008, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor‐in‐Chief, Professor Peter Lichter, and Wiley Periodicals, Inc. A university investigation involving the first and the second‐to‐last author determined that several figures from another published paper were manipulated or duplicated and re‐used in this paper. Therefore, the authors are retracting the paper in its entirety although they maintain that these issues did not affect the major conclusions. They apologize for any inconvenience this may have caused.ReferenceWang, Z., Song, W., Aboukameel, A., Mohammad, M., Wang, G., Banerjee, S., Kong, D., Wang, S., Sarkar, F. H. and Mohammad, R. M. (2008), TW‐37, a small‐molecule inhibitor of Bcl‐2, inhibits cell growth and invasion in pancreatic cancer. Int. J. Cancer, 123: 958–966. doi: 10.1002/ijc.23610
Resonance Raman investigation of redox‐induced structural changes of protein and heme in the sensor domain of Ec DOS protein
Authors: El‐Mashtoly Samir F. , Takahashi Hiroto , Kurokawa Hirofumi , Sato Akira , Shimizu Toru , Kitagawa Teizo 
Published: June 2008

AbstractThe direct oxygen‐sensor protein from Escherichia coli (Ec DOS) is a heme‐based signal transducer protein responsible for phosphodiesterase (PDE) activity. We investigated the redox‐dependent conformational changes of the sensor domain (Ec DOSH) of Ec DOS by using ultraviolet resonance Raman (UVRR) spectroscopy excited at 229 and 244 nm in combination with site‐directed mutagenesis. The UVRR‐difference spectra (reduced–oxidized) of the wild‐type (WT) revealed several features for the Trp and Tyr bands, indicating that these residues undergo environmental changes. Some of these features were assigned to Trp53, Tyr126, and Tyr80, which are located near the 2‐vinyl, 4‐vinyl, and propionate side chains of heme, respectively. Other changes of UVRR spectra were assigned to Tyr55, Trp110, and Tyr125, which are located near the surface of Ec DOSH, implying that this protein undergoes global conformational changes upon redox change of heme. Furthermore, the mutation of Tyr55 in the full‐length protein (Ec DOS), which is located in heme proximal side near Trp53, perturbed the PDE activity compared with WT, demonstrating the importance of Tyr55 for the catalytic reaction. Finally, visible RR spectra of Ec DOSH showed significant changes in vibrations of heme peripheral groups upon a redox change. Thus, our results strongly suggest that heme redox changes induce structural changes of the heme side chains, and then are communicated to the surface of the sensor domain through Trp53, Tyr126, and Tyr80, resulting in global changes of the protein conformation. Copyright © 2008 John Wiley & Sons, Ltd.
Folding and Assembly of Fibroin Driven by an AC Electric Field: Effects on Film Properties
Authors: Servoli Eva , Maniglio Devid , Motta Antonella , Migliaresi Claudio 
Published: June 2008

AbstractSilk fibroin from Bombyx mori is a high‐molecular‐weight protein, largely employed in the biomaterials field. Several parameters can affect the folding and assembly of fibroin heavy and light chains. The present work has shown that anisotropic and water‐stable films are produced when fibroin solution is cast under an alternating electric field (AC). The treatment can affect the mechanical, thermal and surface properties of fibroin films. These effects have been related to the alignment of molecular dipoles and the formation of oriented supramolecular assemblies. Cell response is affected by this novel processing: MRC5 fibroblasts, cultured on anisotropic fibroin films, preferentially spread parallel to the field direction 6 h after seeding.magnified image
Parameters affecting TGO growth rate and the lifetime of TBC systems with MCrAlY‐bondcoats
Authors: Toscano J. , Naumenko D. , Gil A. , Singheiser L. , Quadakkers W. J. 
Published: June 2008

AbstractIn the present work different parameters which affect the oxide growth on MCrAlY‐bondcoats have been studied, in an attempt to find a reliable way to define the critical oxide thickness to failure of an EB‐PVD thermal barrier coatings (TBC). It was found that the variation of selected parameters such as oxidation temperature, surface roughness, and bondcoat thickness certainly alters the thermally grown oxide (TGO) growth rate. However, simultaneously the morphology, composition, and/or microstructure of the oxide are changed, which can affect the critical TGO thickness to failure in a TBC system. In contrast, the variation of the oxygen partial pressure of the oxidizing atmosphere led to different TGO growth rates without significantly changing the oxide morphology and composition. Comparing the TGOs grown at different rates in the specimens exposed to high pO2 and low pO2 atmospheres, it was estimated that at failure the oxide scales in both specimens have reached a similar critical thickness.