bluuebunny/crossref_metadata_2025_split huggingface dataset:
A hypoxia-related genes prognostic risk model, and mechanisms of hypoxia contributing to poor prognosis through immune microenvironment and drug resistance in acute myeloid leukemia
Authors: Liu Xin , Wang Li , Kang Qian , Feng Cheng , Wang Jishi 
Published: February 2024

Objective: Acute myeloid leukemia (AML) is a malignant hematologic cancer with poor prognosis. Emerging evidence suggests a close association between AML progression and hypoxia. The purpose of this study was to establish a new risk prognostic model for AML based on hypoxia-related genes, and to explore the mechanisms by which hypoxia-related genes affect the prognosis of AML based on tumor immune microenvironment (TIME) and drug resistance.Methods: The AML patient samples obtained from Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database were classified into C1 and C2 based on hypoxia-related genes, followed by analysis utilizing Gene Ontology (GO), Kyoto Encyclopaedia of Genes and Genomes (KEGG) and Gene Set Enrichment Analysis (GSEA). Through univariate and LASSO Cox regression analysis, the hypoxia-related hub genes 26S proteasome non-ATPase regulatory subunit 11 (PSMD11) and 26S proteasome non-ATPase regulatory subunit 14 (PSMD14) were identified to construct the model. AML patient samples were obtained from the TARGET and The Cancer Genome Atlas (TCGA) databases, serving as the training and the validation sets, and were stratified into high-risk and low-risk group according to the median risk score. The correlations between the model and TIME and anti-tumor drugs were analysed using CIBERSORT and Genomics of Drug Sensitivity in Cancer (GDSC) databases. The expressions of PSMD11/PSMD14 in clinical samples and AML sensitive and drug-resistant cell lines were detected by Western blot and real-time PCR.Results: The C1 group with high expression of hypoxia-related genes had lower overall survival (OS). Immune-related signaling pathways were different between C1/C2, and hypoxia was positively correlated with the activation of mammalian target of rapamycin (mTOR) signaling pathway. The model had good accuracy in both the training and the validation sets. The high-risk group exhibited lower OS and TIME activity, and was more sensitive to several anti-tumor drugs. PSMD11/PSMD14 were highly expressed in relapsed patients and AML drug-resistant cell lines.Conclusion: The established novel risk prognostic model and experiment results offer valuable insights for predicting AML prognosis and guiding drug selection. It also provides a fundamental framework for the mechanisms through which hypoxia impacts AML prognosis by modulating TIME and drug resistance.
Resolving soft X-ray photons with a high-rate hybrid pixel detector
Authors: Hinger Viktoria , Barten Rebecca , Baruffaldi Filippo , Bergamaschi Anna , Borghi Giacomo , Boscardin Maurizio , Brückner Martin , Carulla Maria , Centis Vignali Matteo , Dinapoli Roberto , Ebner Simon , Ficorella Francesco , Fröjdh Erik , Greiffenberg Dominic , Hammad Ali Omar , Hasanaj Shqipe , Heymes Julian , King Thomas , Kozłowski Pawel , Lopez-Cuenca Carlos , Mezza Davide , Mozzanica Aldo , Moustakas Konstantinos , Paternoster Giovanni , Paton Kirsty A. , Ronchin Sabina , Ruder Christian , Schmitt Bernd , Sieberer Patrick , Thattil Dhanya , Xie Xiangyu , Zhang Jiaguo 
Published: February 2024

Due to their high frame rates and dynamic range, large area coverage, and high signal-to-noise ratio, hybrid silicon pixel detectors are an established standard for photon science applications at X-ray energies between 2 keV and 20 keV. These properties also make hybrid detectors interesting for experiments with soft X-rays between 200 eV and 2 keV. In this energy range, however, standard hybrid detectors are limited by the quantum efficiency of the sensor and the noise of the readout electronics. These limitations can be overcome by utilizing inverse Low-Gain Avalanche Diode (iLGAD) sensors with an optimized X-ray entrance window. We have developed and characterized a prototype soft X-ray iLGAD sensor bonded to the charge integrating 75 µm pixel JUNGFRAU chip. Cooled to −22°C, the system multiplication factor of the signal generated by an impinging photon is ≥ 11. With this gain, the effective equivalent noise charge of the system is ≤5.5 electrons root-mean-square at a 5 µs integration time. We show that by cooling the system below −50°C, single photon resolution at 200 eV becomes feasible with a signal-to-noise ratio better than 5.
Perceived discrimination as a mediator between cultural identity and mental health symptoms among racial/ethnic minority adults in the United States: insights from the Health Information National Trends Survey 6
Authors: Zhou Lulin , Nutakor Jonathan Aseye , Larnyo Ebenezer , Addai-Dansoh Stephen , Cui Yupeng , Dey Nutifafa Eugene Yaw 
Published: February 2024

ObjectiveThis study examined the role of perceived discrimination as a mediator between cultural identity and mental health symptoms among adults from racial/ethnic minority groups in the United States.MethodsData were gathered from the National Cancer Institute’s (NCI) Health Information National Trends Survey (HINTS) 6, a nationally representative survey. The mediating role of perceived discrimination was investigated using structural equation modeling (SEM) analysis.ResultsThe study found significant associations between demographic and lifestyle factors and mental health symptoms. Non-Hispanic Blacks or African Americans and Hispanics were less likely than Non-Hispanic Whites to have mental health symptoms. Individuals between the ages of 35 and 49, 50 to 64, 65 to 74, and 75 and older had lower odds of mental health symptoms. Gender differences revealed that females had a higher risk of mental health issues than males. Socioeconomic factors, such as household income and employment status, played a significant role, with higher household income and employment status being associated with a decreased likelihood of mental health symptoms. The study emphasizes the role of perceived discrimination as a mediator, suggesting that it fully mediated the association between cultural identity and mental health symptoms. These findings highlight the significance of addressing discrimination experiences in fostering the mental health of adults from diverse backgrounds.ConclusionThe findings highlight the need to take racial, ethnic, and socioeconomic inequities, as well as cultural identity and prejudice, into account in mental health research and interventions. The identified risk and protective factors can guide interventions and policies to enhance this population’s mental health.
Development and validation of fall risk perception scale for patients with Parkinson’s disease
Authors: Yang Xin , Yao Meiqi , Guo Zhiting , Shen Xuhui , Jin Jingfen 
Published: February 2024

BackgroundPerception assessment plays an important role in fall risk awareness and fall prevention. Parkinson’s disease patients with motor dysfunction are at high risk of falling. Currently, no instrument has been explicitly crafted to assess the risk perception of fall in PD patients. The purpose of this study was to develop and validate the fall risk perception scale for PD patients (FRPS-PD), providing healthcare professionals with a effective assessment tool to enhance proactive fall prevention initiatives.MethodBased on the Proactive Health theory and Risk Perception Attitude (RPA) Framework, the questionnaire was developed through literature review, semi-structure interview, expert consultation and pilot testing. A total of 428 patients with PD from Grade A tertiary hospitals in Shanghai, Hangzhou and Anhui from January 2023 to July 2023 were recruited. The items and dimensions in the scale were explored and confirmed using item-analysis, content validity, exploratory factor analytical (EFA), confirmatory factor analytical (CFA), internal consistency and test–retest reliability analysis.ResultsA total of 16-items, 2-dimensions structure were identified, including 12 items of risk perception and 4 items of self-efficacy dimension. The cumulative variance of EFA model was 73.669%, further CFA showed that acceptable model fit (χ2/df = 2.226, RMSEA = 0.074, NF = 0.928, TLI = 0.951, CFI = 0.959, GFI = 0.887 and AGFI = 0.848). The content validity index was 0.956. The reliability of the scale was 0.952 using Cronbach’s α coefficient method. The test–retest reliability was 0.944.ConclusionThe FRPS-PD is a valid and reliable measurement for evaluating fall risk perception level for individuals with PD in mainland China.
Water, sanitation and hygiene at sex work venues to support menstrual needs
Authors: Phillips-Howard Penelope A. , Osire Edyth , Akinyi Cynthia , Zulaika Garazi , Otieno Fredrick O. , Mehta Supriya D. 
Published: February 2024

IntroductionAdequate menstrual health and hygiene (MHH) is necessary for women's health and equity of all menstruators. Female sex workers (FSW) require good MHH to prevent discomfort and exposure to pathogens. No studies have evaluated water, sanitation, and hygiene (WASH) conditions of FSW. We report on a cross-sectional WASH assessment at FSW venues in Kisumu, western Kenya.MethodsStakeholders identified 77 FSW venues in Kisumu, of which 47 were randomly sampled and visited between April–May 2023. A standardized structured survey of WASH conditions was deployed by trained research staff using Android tablets after proprietor's consent. WASH scores ranging 0–3 were computed based on point each for direct observation of water available, soap available, and acceptable latrine. MHH scores ranging between 0–4 were computed (one point each) for direct observation of: currently available soap and water, locking door on a usable latrine, functional lighting, and a private area for changing clothes or menstrual materials, separate from the latrine(s). WASH and MHH scores were compared by venue type using non-parametric Kruskal-Wallis tests, and non-parametric Spearman rank tests.ResultsFull WASH criteria was met by 29.8% of venues; 34.0% had no adequate WASH facilities; 46.8% had no female latrine; and 25.5% provided soap and water in private spaces for women. While 76.6% had menstrual waste disposal only 14 (29.8%) had covered bins. One in 10 venues provided adequate MHM facilities. Poorest WASH facilities were in brothels and in bars, and three-quarters of bars with accommodation had no MHH facilities.DiscussionWASH and MHH services were sub-optimal in the majority of FSW venues, preventing menstrual management safely, effectively, with dignity and privacy. This study highlights the unmet need for MHH support for this population. Poor MHH can deleteriously impact FSW health and wellbeing and compound the stigma and shame associated with their work and ability to stay clean. Acceptable and cost-effective solutions to sustainably improve WASH facilities for these populations are needed.Trial registrationClinicaltrial.gov NCT0566678.
Chitogel improves long-term health economic outcomes following endoscopic sinus surgery in severe chronic rhinosinusitis patients
Authors: Barber Jacqueline M. , Bouras George , Robinson Grace S. , Robinson Simon R. 
Published: February 2024

IntroductionChronic rhinosinusitis causes severe symptoms that can affect patient quality of life. Endoscopic sinus surgery can be effective in improving symptoms, although surgical outcomes can be compromised post-operatively, and revision surgery is required in a proportion of patients. This study compares outcomes and healthcare resource use in patients undergoing sinus surgery with or without Chitogel as a post-operative dressing.MethodsA retrospective cohort study was conducted using deidentified audit data from adult patients with severe chronic rhinosinusitis, who underwent endoscopic sinus surgery between January 2016 and December 2021. Patients in the intervention group received Chitogel as a post-operative dressing, and control patients received standard best-practice care. Cox Proportional Hazards survival analysis was used to compare revision surgery rates and time to revision between treatment groups. The rate of revision surgery was used to estimate potential health sector savings associated with use of Chitogel following surgery compared to the control arm, considering initial treatment costs and the cost of revision surgery.ResultsOver 18–24 months, patients treated with Chitogel demonstrated significantly lower rates of revision surgery (p = 0.035), and a trend towards decreased use of post-operative steroids, compared to control. Potential health sector savings due to reduced rates of revision surgery following use of Chitogel are estimated as NZ $753,000 per 100 patients.ConclusionSevere chronic rhinosinusitis patients treated with Chitogel had lower rates of revision surgery within the first 18–24 months post-operative. These findings suggest that use of Chitogel can improve long-term patient outcomes and should improve health system efficiency.
GINGERINO: a high sensitivity ring laser gyroscope for fundamental and quantum physics investigation
Authors: Giovinetti Francesco , Altucci Carlo , Bajardi Francesco , Basti Andrea , Beverini Nicolò , Capozziello Salvatore , Carelli Giorgio , Castellano Simone , Ciampini Donatella , Di Somma Giuseppe , Di Virgilio Angela D. V. , Fuso Francesco , Lambiase Gaetano , Maccioni Enrico , Marsili Paolo , Ortolan Antonello , Porzio Alberto , Velotta Raffaele 
Published: February 2024

Ring Laser Gyroscopes, based on the Sagnac effect, are currently the most sensitive rotation sensors. GINGERINO, a RLG installed underground, shows a proved sensitivity that enters the few frad/s regime in about 2.5 days of integration time. On one hand, this sensitivity is well below the shot–noise–level as predicted applying to GINGERINO the so called independent beam model. On the other hand, it paves the way to the use of RLG in fundamental and quantum physics research. Indeed, high sensitivity rotation measurement opens to test general relativity and alternative theory of gravity. Moreover, it make possible to study the interplay between quantum effects in the optical domain and non-inertial reference frames.
The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study
Authors: Aksu Bagdagul , Afonso Alberto Caldas , Akil Ipek , Alpay Harika , Atmis Bahriye , Aydog Ozlem , Bakkaloglu Sevcan , Bayazıt Aysun Karabay , Bayram Meral Torun , Bilge Ilmay , Bulut Ipek Kaplan , Cetinkaya Ayse Pinar Goksu , Comak Elif , Demir Belde Kasap , Dincel Nida , Donmez Osman , Durmus Mehmet Akif , Dursun Hasan , Dusunsel Ruhan , Duzova Ali , Ertan Pelin , Gedikbasi Asuman , Goknar Nilufer , Guven Sercin , Hacihamdioglu Duygu , Jankauskiene Augustina , Kalyoncu Mukaddes , Kavukcu Salih , Kenan Bahriye Uzun , Kucuk Nuran , Kural Bahar , Litwin Mieczysław , Montini Giovanni , Morello William , Obrycki Lukasz , Omer Beyhan , Misirli Ozdemir Ebru , Ozkayin Nese , Paripovic Dusan , Pehlivanoglu Cemile , Saygili Seha , Schaefer Franz , Schaefer Susanne , Sonmez Ferah , Tabel Yilmaz , Tas Nesrin , Tasdemir Mehmet , Teixeira Ana , Tekcan Demet , Topaloglu Rezan , Tulpar Sebahat , Turkkan Ozde Nisa , Uysal Berfin , Uysalol Metin , Vitkevic Renata , Yavuz Sevgi , Yel Sibel , Yildirim Tarik , Yildirim Zeynep Yuruk , Yildiz Nurdan , Yuksel Selcuk , Yurtseven Eray , Yilmaz Alev 
Published: February 2024

BackgroundCongenital anomalies of the kidney and urinary tract (CAKUT) are defined as structural malformations of the kidney and/or urinary tract. Heat shock proteins (HSPs) are expressed in the kidney in response to cellular changes, such as thermal, hemodynamic, osmotic, inflammatory, and mechanical stresses. This study aimed to assess uHSP70 levels during acute urinary tract infections (UTI) and non-infection periods in patients with CAKUT, and to evaluate whether uHSP70 is elevated in CAKUT subtypes.MethodsAmong patients with CAKUT, 89 patients with UTI (CAKUT-A), 111 without UTI (CAKUT-B), and 74 healthy children were included in the study. uHSP70 levels were measured using enzyme-linked immunosorbent assay (ELISA).ResultsuHSP70 level was significantly higher in the CAKUT-A group than in the CAKUT-B and healthy control groups (p &lt; 0.0001). Moreover, the level of uHSP70 was significantly higher in the CAKUT-B group than in the control group (p &lt; 0.0001), but was not different between the CAKUT subtypes (p &gt; 0.05).ConclusionUrine HSP70 can also be used to predict UTI in patients with CAKUT. Moreover, uHSP70 levels were higher in children with CAKUT during the non-infectious period than in healthy controls. This suggests that children with CAKUT are at risk of chronic non-infectious damage.
Incidence, Healthcare Resource Use and Costs Associated With Incisional Hernia Repair
Authors: Smith Laurie , Wilkes Emily , Rolfe Chris , Westlake Petra , Cornish Julie , Brooks Paul , Torkington Jared 
Published: February 2024

Background: Incisional hernia (IH) is a common complication of abdominal surgery affecting between 12.8% and 30% of patients. In spite of this, rates of IH repair remain low, at around 5% in the literature. We aimed to assess the rate of IH repair in the UK across surgical specialties and the cost burden associated with IH repair.Methods: This is a retrospective observational study of patients undergoing abdominal surgery in England between 2012 and 2022 using the Hospital Episode Statistics (HES) database. Index abdominal surgery was identified between March 2014 and March 2017. Diagnostic and surgical procedure codes were used to identify pre-operative risk factors, index surgeries, IH repair and healthcare contact. Healthcare resource use (HCRU) costs were derived for index surgery and all post-index, non-elective inpatient admissions and outpatient visits using Healthcare Resource Group (HRG) codes within HES.Results: Of 297,134 patients undergoing abdominal surgery, 5.1% (n = 15,138) subsequently underwent incisional hernia repair. By specialty, rates were higher in Colorectal (10.0%), followed by Hepatobiliary (8.2%), Transplant (6.8%), Urological (4.0%), Bariatric (3.5%), Vascular (3.2%) and Gynaecological (2.6%) surgery. Patients undergoing IH repair had more healthcare contacts, longer length of inpatient stays and more A+E visits vs. those with no IH repair post index surgery (83% ≥ 1 A+E visit vs. 69%), as well as higher rates of referral to mental health services (19.8% vs. 11.5%). IH repair was associated with an average HCRU cost of £23,148 compared to £12,321 in patients with no IH repair.Conclusion: Patients undergoing IH repair have a greater morbidity than those not undergoing repair, shown by higher HCRU and more healthcare contacts. Despite this, rates of surgery for IH are low, suggesting that most patients with hernias are not undergoing repair. Emphasis must be placed squarely on primary prevention, rather than cure.
Real-world data: a comprehensive literature review on the barriers, challenges, and opportunities associated with their inclusion in the health technology assessment process
Authors: Zisis Konstantinos , Pavi Elpida , Geitona Mary , Athanasakis Kostas 
Published: February 2024

Objective: This review aimed to assess the current use and acceptance of real-world data (RWD) and real-world evidence (RWE) in health technology assessment (HTA) process. It additionally aimed to discern stakeholders’ viewpoints concerning RWD and RWE in HTA and illuminate the obstacles, difficulties, prospects, and consequences associated with the incorporation of RWD and RWE into the realm of HTA.Methods: A comprehensive PRISMA-based systematic review was performed in July 2022 in PubMed/Medline, Scopus, IDEAS-RePEc, International HTA database, and Centre for Reviews and Dissemination with ad hoc supplementary search in Google Scholar and international organization websites. The review included pre-determined inclusion criteria while the selection of eligible studies, the data extraction process and quality assessment were carried out using standardized and transparent methods.Results: Twenty-nine (n = 29) studies were included in the review out of 2,115 studies identified by the search strategy. In various global contexts, disparities in RWD utilization were evident, with randomized controlled trials (RCTs) serving as the primary evidence source. RWD and RWE played pivotal roles, surpassing relative effectiveness assessments (REAs) and significantly influencing decision-making and cost-effectiveness analyses. Identified challenges impeding RWD integration into HTA encompassed limited local data access, complexities in non-randomized trial design, data quality, privacy, and fragmentation. Addressing these is imperative for optimal RWD utilization. Incorporating RWD/RWE in HTA yields multifaceted advantages, enhancing understanding of treatment efficacy, resource utilization, and cost analysis, particularly via patient registries. RWE complements assessments of advanced therapy medicinal products (ATMPs) and rare diseases. Local data utilization strengthens HTA, bridging gaps when RCT data is lacking. RWD aids medical device decision-making, cancer drug reassessment, and indirect treatment comparisons. Challenges include data availability, stakeholder acceptance, expertise, and privacy. However, standardization, training, collaboration, and guidance can surmount these barriers, fostering enhanced RWD utilization in HTA.Conclusion: This study highlights the intricate global landscape of RWD and RWE acceptance in HTA. Recognizing regional nuances, addressing methodological challenges, and promoting collaboration are pivotal, among others, for leveraging RWD and RWE effectively in healthcare decision-making.
Determinan Kejadian Stunting; Studi Survay Analitik
Authors: Ibrahim Fitriana , Rahayu Bakti , Ibrahim Ajeng Anggreny , Haryaningsih Sri Anggreny 
Published: February 2024

Latar Belakang: Stunting adalah permasalahan gizi yang dialami balita dengan ciri tinggi badan yang kurang dari indeks tinggi badan balita 2-5 tahun. Stunting bisa berdampak pada kesehatan dan kecerdasan anak.
Tujuan: Untuk mengetahui beberapa faktor yang berkaitan dengan kejadian stunting pada balita umur 24-59 bulan di Kecamatan Bajo Barat
Metode: Menggunakan survey analitik dengan pendekatan observasi. Populasi berjumlah 83 orang dengan sampel 45 orang, teknik pengambilan sampel Probability sampling dan menentukan ukuran sampel dengan rumus Slovin. Pengumpulan data dengan membagikan kuisioner. Data diolah dengan menggunakan SPSS versi 25 dan analisis secara univariat dan bivariat dengan uji statistic chi-square serta disajikan dalam bentuk table distribusi frekuensi dan analisis.
Hasil: Analisa bivariat didapatkan hubungan ASI eksklusif dengan kasus Stunting (ρ-Value = 0,003) , tingkat pendidikan dengan kejadian Stunting ( ρ-Value = 0,003 ) dan Pendapatan Keluarga dengan kejadian Stunting ( ρ-Value = 0,000 ).
Kesimpulan: terdapat hubungan pemberian ASI eksklusif, tingkat pendidikan dan pendapatan keluarga dengan kejadian stunting pada balita umur 24-59 bulan di wilayah kerja Puskesmas Bajo Barat
Kata kunci : Stunting, Asi Eksklusif, Pendapatan Keluarga, Tingkat Pendidikan