bluuebunny/crossref_metadata_2025_split huggingface dataset:
(026) Application of Gelatin Sponge as a Hemostatic Agent in Penile Prosthesis Implantation
Authors: Mahmoud O 
Published: March 2024

Abstract

Introduction
Gelfoam® Sterile Compressed Sponge is a hemostatic that is directly applied to bleeding surfaces. This cost-effective hemostatic agent is prepared from purified porcine skin, Gelatin granules and Water for Injection. It is water insoluble, however is completely absorbed within 4–6 weeks with minimal scar formation. Gelfoam is available sterile for intra-operative use, and is applied in a multitude of surgical specialties.

Objective
In this work, we demonstrate for the first time the of Gelfoam to minimize the risk of bleeding in penile prosthesis implantation.

Methods
Eight cases received a three-piece inflatable implant (Rigicon Infla10®) through a peno-scrotal incision. Following cylinder insertion, corporotomies were closed by tying the stay sutures rather than water-tight sewing. Gelfoam was soaked in antibiotic-supplemented saline. Air bubbles were squeezed out followed by soaking. Gelfoam was then applied to the corporotomies, pump space and entry rout to the reservoir space. It was secured over the corporotomies by closing a pre-fashioned layer of Buck’s fascia. A suction drain was inserted. Mummy wrap was not used. Drain output was monitored and complications recorded.

Results
In two cases, drain output was an average of 80 cc’s in the first 24 hours, then 20 cc’s in the following 24 hours. However, in 6 cases, drain output was an average of 18 cc’s in the first 24 hours, mostly sero-sanguinous, then none in the following 24 hours. No cases of hematoma formation, infection, foreign body reaction, mass formation or hypersensitivity reaction were encountered.

Conclusions
The initial results of the current small case series demonstrate that Gelfoam is well-tolerated in penile surgeries, with possible value at minimizing post-operative bleeding, encouraging a multi-center larger study.

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(053) Efficacy of Mindfulness Based Cognitive Therapy in Management of Provoked Vulvodynia: A Feasibility Pilot Study
Authors: Bilal A , Altaf S 
Published: March 2024

Abstract

Introduction
Provoked Vulvodynia (PVD) is an evolving and chronic pain disorder frequently reported by women of reproductive age. Provoked Vulvodynia is a debilitating disorder and causes significant impairment in daily functioning.

Objective
The present study was designed with an aim to compare the efficacy of mindfulness based cognitive therapy (MBCT) with pharmacotherapy in the management of PVD in Pakistani women.

Methods
The present study was approved by the Ethics Review Board (ERB) of Institute of Psychological Research, Pakistan vide No. IPR/ERB/PVD/2023/006. A randomized trial design was used in this study. The women suffering from vulvodynia were included in the study. On the other hand, the women suffering from any gynecological disease, psychiatric disease, or any other medical disease or using any substance were excluded from the study. A total of 43 women suffering from PVD were referred for the treatment. 14 women were excluded as they did not meet the inclusion criteria. All women signed the compulsory informed consent form before enrolling for the study. 29 women were randomized in two treatment groups namely Group A which received 1 hour weekly session of mindfulness based cognitive therapy and Group B which received pharmacotherapy for a period of 3 months. Pharmacotherapy included Amitriptyline 25–50mg daily, Gabapentin 100–300 mg daily, and Lidocaine ointment 5% applied locally to the vestibule. There were 14 women in Group A and 15 women in Group B. A total of 6 women were dropped from the Group A and Group B because they did not want to complete the treatment protocol. 11 women in Group A and 12 women in Group B completed the treatment protocol and their data were added to the statistical analyses. The Vulvar Pain Functional Questionnaire (V-Q) was used as the main outcome measure for pretest and posttest assessments. The data was analyzed by using the Statistical Package for the Social Sciences (SPSS) version 27.

Results
The mean age of the women was (M=34, SD=3.13) for Group A and (M=34.41, SD=3.26) for Group B. The data was analyzed by using the Wilcoxon Signed Rank Test as the data was non parametric. There was statistical significant Z= -2.94, p&lt;.05 for Group A and Z= -3.07, p&lt;.05 for Group B. The results established that both mindfulness based cognitive therapy and pharmacotherapy were effective in relieving symptoms of PVD.

Conclusions
The present study concluded that mindfulness based cognitive therapy was as effective in relieving symptoms of PVD as pharmacotherapy. The lack of control group was a major limitation of the study. However, the future studies may be conducted with other treatment arms such as pelvic floor therapy and by adding more women in treatment and control groups. The present study may be considered as a feasibility/pilot study for the efficacy of MBCT for treatment of PVD in Pakistani women.

Disclosure
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(055) Vaginal Lubrication: Equally Important for Orgasm in Premenopausal, Postmenopausal, and Post-Partum Women?
Authors: Dubinskaya A , Dallas K , Harper L , Shoureshi P , Krychman M , Eilber K 
Published: March 2024

Abstract

Introduction
The female sexual response cycle is complex with interconnected domains. Studies have shown that vaginal lubrication is affected by age and hormonal changes; however, the relationship between lubrication and orgasm has not been well described in premenopausal women, women who are postpartum, and postmenopausal women.

Objective
The objective of this study is to evaluate the relationship between vaginal lubrication and orgasm among premenopausal, postpartum, and postmenopausal women

Methods
A post-market analysis was performed of all women who had utilized the sexual wellness application Rosy between February 2022 and November 2022. Application users complete the Female Sexual Function Index (FSFI) short form (6-item) upon initial use of the application. We utilized multivariable linear regression models to determine significant effects between lubrication score and orgasm scores score controlling for whether the patient was on birth control, postpartum, or menopausal

Results
We reviewed a large database of 30,358 women from across the United States. Among these, 2,599 women were menopausal, 2, 011 were premenopausal women, and 795 were postpartum. The mean lubrication scores on FSFI -6 were: menopausal = 1.93, premenopausal = 2.68, postpartum = 2.73. Mean scores for orgasm were 2.2, 2.62, 2.31 respectively. Premenopausal women had higher overall scores on FSFI- 6, with orgasm scores improving with age. Higher scores in lubrication domain had less impact on orgasm domain in pre-menopausal women compared to post-menopausal women (p=0.04). No correlation between improvement in lubrication and orgasm noted among post-partum women when compared to post-menopausal women (p=0.87)

Conclusions
Lubrication has a higher impact on orgasm among post-menopausal women compared to pre-menopausal women and not correlated with orgasmic function among women in the post-partum period. These findings enhance our knowledge and refine current management of anorgasmia.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: Rosy.
(079) Perception of Signals of Sexual Interest in Patients with Schizophrenia
Authors: Biedkova P , Androvičová R , Novák O , Ständer K 
Published: March 2024

Abstract

Introduction
Patients with schizophrenia (SCH) face many difficulties in forming and maintaining sexual relationships and often have unmet needs around intimacy. Low satisfaction with sexual relationships has been linked to a decrease in overall quality of life. Single relationship status also correlates with a poorer prognosis. However, the exploration of sources of sexual and relationship deficits in patients is an area that is habitually neglected, and there is little research addressing this phenomenon.

Objective
Our study aims to identify whether difficulties in forming sexual relationships reported by patients with SCH could be connected to: a) a compromised ability to interpret, recognize and respond to signals of sexual interest b) decreased salience of sexual intimacy.

Methods
Sample: Twenty male and female patients with schizophrenia and a control group of the same size, matched for demographic parameters, will be recruited from the Study of first episodes of schizophrenia (ESO). ESO is a large prospective database dedicated to the longitudinal follow-up of first-episode patients with SCH which contains a wealth of information on bio-psycho-social markers. Procedure: The variables of interest will be tested by two experiments developed in our laboratory. The first experiment depicts male and female actors showing behavioral displays conveying signals of a) sexual interest, b) neutral but friendly attitude and c) rejection, towards the observer. The second experiment is a simple viewing task designed to assess the salience of erotic stimuli compared to neutral ones. In addition, eye movements and pupil dilation will be measured using the eye-tracking device Eyelink 1000plus. Statistical analysis: A repeated-measures t-test will be used to assess the change in a continuous outcome.

Results
Preliminary results show that the patients (N=10) spent more time on erotic images (mean time= 884.69 ms) than the control group (N=9) (mean time= 772.14 ms). This difference is not statistically significant (p = 0.21). Currently, more data are being collected.

Conclusions
The preliminary results demonstrate that there is no difference in the interest in explicit sexual stimuli between patients with SCH and healthy controls. Explicit erotic signals seem to be sexually salient to them, which indicates their interest in sexual intimacy. Our research will further determine whether individuals with SCH have impaired ability to perceive, interpret, and react to signals of sexual interest. The implications of our findings could lead to a formulation of sexual remediation strategies. The study was supported by the Czech Health Research Council, no. NU21J-04-00024 and the Charles University, Fac Med1, GAUK no. 56123.

Disclosure
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(103) Prior Intracavernosal Injection Therapy and Prostate Cancer Treatment are Both Independently Associated with Increased Risks of Complications in Men Undergoing Inflatable Penile Prosthesis Placement
Authors: Hammad M A M , Barham D W , Jones J M , Gross M S , Chang C , Swerdloff D , Miller J , Andrianne R , Burnett A L , Gross K , Hatzichristodoulou G , Hotaling J M , Hsieh T C , Jones A , Lentz A , Modgil V , Osmonov D , Park S H , Pearce I , Perito P , Sadeghi-Nejad H , Sempels M , Suarez-Sarmiento Jr. A , Simhan J , Van Renterghem K , Warner J N , Ziegelmann M , Yafi F A ,   on behalf of the PUMP (Prosthetic Urology Multi-institutional Partnership) collaborators
Published: March 2024

Abstract

Introduction
Intracavernosal injection (ICI) therapy for erectile dysfunction (ED) carries a risk of corporal fibrosis, potentially making placement of an inflatable penile prosthesis more difficult. Prostate cancer treatment may also induce corporal fibrosis.

Objective
To assess whether a history of ICI or prostate cancer treatment is associated with complications following IPP placement.

Methods
A retrospective cohort study of primary IPP cases from 2016–2021 across 16 institutions. Patients were stratified by history of ICI and between-group differences in risk factors were assessed. Multivariable logistic regression was used to assess for predictors of intraoperative complications, postoperative non-infectious complications and postoperative infection.

Results
A total of 2540 patients met inclusion criteria of which 781 (30.8%) had a history of ICI. Patients with a history of ICI tended to be older (mean 63 vs 64 years, p=0.002) and were more likely to have history of radical prostatectomy (21.0% vs. 32.1%, p&lt;0.001) and/or radiation (5.51% vs 10.9%, p&lt;0.001). On multivariable regression, a history of ICI, prostatectomy, and radiation were all significant predictors of intraoperative complications (OR 2.11, p=0.03; OR 2.27, p=0.03; OR 2.40, p=0.04, respectively). A history of ICI and patient age were predictors of non-infectious postoperative complications (OR 1.44, p=0.02, OR 1.02, p=0.004 respectively)). None of the variables were significant predictors of infection.

Conclusions
In men undergoing IPP placement, a history of ICI is associated with an increased risk of both intraoperative and postoperative, non-infectious complications. Prostate cancer treatment with radiation or surgery is independently associated with increased risk of intraoperative complications.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: D.O. has served as a consultant for Coloplast, Intuitive Surgical, and Fidelis. P.P. has served as a consultant for Coloplast, Boston Scientific, and Urofill. M.S. has served as a consultant for Boston Scientific and Coloplast. J.S. has served as a consultant for Boston Scientific and Coloplast. F.A.Y. has served as a consultant for Coloplast, Cynosure, Antares Pharma, Clarus Pharmaceuticals, and Acerus Pharma. M.S.G. has served as a consultant for Coloplast. The other authors disclose no conflicts.
(150) Assessment of Using the Syndromic Approach in Managing Patients with Sexually Transmitted Diseases Among the National Guard Primary Health Care Physicians, Jeddah City, Saudi Arabia
Authors: Al-Mugti H , Banamah O 
Published: March 2024

Abstract

Introduction
Sexually transmitted infections (STIs) include a group of clinical syndromes that can be transmitted mainly through sexual activity. Using STIs’ syndromic approach for diagnosis and management is widely recommended to control and reduce the burden of these transmissible diseases

Objective
to assess the knowledge and practice of physicians concerning syndromic management of STIs in National Guard Primary Health Care (PHC) centers in Jeddah city, Saudi Arabia.

Methods
This observational study was conducted at the National Guard PHC centers in Jeddah City, Saudi Arabia. An interview-administered questionnaire was designed. Fifty physicians have met the inclusion criteria, and all of them were included in the present study.

Results
Of the study population, 47 PHC physicians (response rate was 94%) were interviewed and the questionnaire was completed. Overall, the physicians' knowledge was different from one syndrome to another; it was highest for urethral discharge (72%) and lowest for vaginal discharge in pregnant women (21%). During the last 10 days, the physicians in the present study reported that two-thirds of their cases of STI were urethral discharge cases. However, during the previous 10 days, the practice assessment revealed that most physicians (76%) were correctly prescribed the medications as indicated by specific patients' syndromes.

Conclusions
Syndromic management is essential guidance to control and reduce the burden of STIs. Overall knowledge and practice of physicians were different from one syndrome to another. There is a need to design continuing medical education programs targeting PHC physicians to be clinically and culturally competent against socially sensitive diseases like STIs.

Disclosure
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(175) Knowledge, Attitude, and Practice on Sexual and Reproductive Health among Adolescent in Malaysia: A Systematic Review
Authors: Mustafa Kamal N A 
Published: March 2024

Abstract

Introduction
A good sexual and reproductive health (SRH) encompasses dimensions of physical, emotional, mental and social-wellbeing in relation to sexuality; it is not merely the absence of disease, dysfunction, or infirmity. A proper curriculum is needed to ensure that all adolescents have a good grasp of knowledge of SRH to have proper attitudes and the right practices in SRH.

Objective
Currently, it is believed that there is no improvement in status of knowledge, attitude and practice of SRH among adolescents in Malaysia, despite the introduction of sexual and reproductive health topics in the school curriculum. No systematic or proper evaluation to evaluate the effectiveness of the said improved SRH curriculum. This review aims to investigate the status of level of knowledge among adolescents since the introduction of SRH curriculum.

Methods
A systematic literature review in the form of narrative review was used to investigate the status of knowledge, attitude, and practice of SRH. 109 potential articles were found through Medline, PubMed, Google Scholar and Google. Articles removed due to duplications within and between databases. 109 potential articles were found but only 29 articles met the inclusion/exclusion criteria. Selected articles were read through based on the 8 key concepts in the International Technical Guidance on Sexuality Education, 2018.

Results
The results reported that the knowledge of sexual health among adolescents was just above the average, while poor knowledge in reproductive health. They have a positive attitude towards introducing SRH curriculum as early as primary school. It was found that these adolescents have poor information-seeking behavior, and main resources of information are from peers, internet, and magazine. Parents and teachers were the least chosen as reference.

Conclusions
There is the need to re-evaluate the current SRH curriculum, and to integrate the healthcare personnel as educator to the adolescents, trainers to the teachers and parents to ensure a holistic approach to a proper SRH education following the CSE guideline.

Disclosure
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(178) Climacturia: Emerging Type of Urinary Incontinence, Its Prevalence, Risk Factors, and Management: A Systematic Review and Prevalence Meta-analysis
Authors: De Guzman S , Wilson T 
Published: March 2024

Abstract

Introduction
Climacturia is an emerging type of urinary incontinence which occurs immediately following orgasm. Both men and women may suffer from climacturia in equivocal rates. This phenomenon is becoming more problematic as it impacts physiological and psychosexual aspect of well-being and quality of life. While awareness of climacturia becomes evident, studies are inadequate to support evidenced-based management in primary and urologic care settings.

Objective
This study aimed to conduct a systematic review and prevalence meta-analysis of climacturia and investigate its risk factors and evidenced-based management.

Methods
A systematic review of 24 articles were conducted following PRISMA 2020 guidelines. The PubMed, CINAHL, and Cochrane Library database were searched using the word “climacturia” and phrase “orgasm associated urinary incontinence” respectively. Search limiters applied included literature written in English from year of inception to 2022. Title and abstract reviews were conducted on 78 articles. Articles which did not discuss climacturia, duplicates, and previous systematic reviews were excluded after full article review.

Results
The review accounts a total of N = 7798 subjects which are composed of N = 7629 (97.83%) males and N = 169 (2.17%) females with age range of 18 to 80 years old. A total of N = 2, 039 (26%) participants are with climacturia, N = 87 or 4.26% are females and N = 1, 931 or 95.74% are males. The risk factors associated with climacturia include sexually active male, history of prostate cancer after prostatectomy within 12 months of surgery or radiation therapy, increased Body Mass Index (BMI), erectile dysfunction (ED), increased urethral width, presence of urinary incontinence, pain-associated orgasm and loss of penile length after pelvic surgery, use of aides to obtain an erection, and increased incontinence scores for men. For women, the risk factors are high scores of female sexual function index (FSFI) and detrusor overactivity. The management for females is limited to pharmacologic therapy with use of antimuscarinic agents. While, behavioral therapy, pharmacologic regimen, pelvic floor muscle training (PFMT), surgery (sling procedure) are the management options for affected men.

Conclusions
Climacturia affects males more than females, however, the evidence to support the efficacy of treatment options for both sexes are equally inadequate. Primary care and Advanced Practice Providers in primary and urologic care settings are at best position to query patients for the presence of and manage climacturia in timely manner. Further research is needed to increase evidence supporting effective management of climacturia for both men and women.

Disclosure
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(180) Female Sexuality of Tunisian Women with Treated Breast Cancer
Authors: Souayeh N , Bettaieb H , Rouis H , Mbarki C , Hsayaoui N 
Published: March 2024

Abstract

Introduction
Breast cancer is a major health problem. Several treatment strategies are used to treat it such as lumpectomy or mastectomy surgery, chemotherapy, radiotherapy, and hormone therapy, which leads us to ask the following question: what impact does breast cancer and its treatments have on female sexuality?

Objective
The aims of our study were to assess the sexuality of Tunisian women with breast cancer in remission, and to determine the prevalence and nature of sexual dysfunction in this population.

Methods
We carried out a descriptive cross-sectional study, involving women aged under 60, followed up for treated non-metastatic breast cancer currently in remission, and having a regular sexual partner during the last month. Outpatients in the surgery and radiotherapy department of the "Salah-Azaiez" Institute were interviewed using a questionnaire including a validated Arabic version of FSFI (Female sexual function desire). Our study was carried out throughout a period of 3 months, from January 1st, 2023 to March 31st, 2023, this period allowed us to collect our necessary data.

Results
We included 120 women in our study. The majority were between 40 and 49 years with an average of 46.53. One-third (33.3%) had a university degree and 16.7% were senior executives. More than half of our population (56.7%) were menopausal and 12% were smokers. 85% of the women had children, and only 36% had breastfed their children exclusively. Half of the women had discovered the disease at stage II, and 52% of them had discovered it during breast self-examination. Surgical treatment was radical in 61.7% of women and conservative in 38.3%. Thus, 75% of the population had undergone chemotherapy, 93.3% had undergone radiotherapy and 71.7% were receiving hormone therapy. Only 5% of our study population had a sexual dysfunction prior to the disease and 78% of women had reported a change in their sex life after breast cancer, with the frequency of intercourse as the main parameter affected. Among the most common sexual complaints were decreased or absent sexual desire in 68.1% of cases, lack of sexual initiative (74.4%), vaginal dryness (48.9%), and dyspareunia (42.6%). The majority of interviewed women (83.3%) had presented with global sexual dysfunction, i.e. a total FSFI score ≤26.55 and the areas most affected were pain, lubrication, and orgasm. Radical surgical treatment, chemotherapy, and hormone therapy were significantly associated with impaired female sexuality (respectively p=0.0036; p=0.047 and p=0.001).

Conclusions
Our study highlighted the impact of breast cancer treatment on women's sex lives. Healthcare providers should acquire the necessary skills in order to explore female sexual disorders and suggest suitable management.

Disclosure
No.