bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends and Disparities in Cardiovascular Death in Sarcoidosis: A Population‐Based Retrospective Study in the United States From 1999 to 2020
Authors: Tan Min Choon , Yeo Yong Hao , Mirza Noreen , San Boon Jian , Tan Jian Liang , Lee Justin Z. , Mazzarelli Joanne K. , Russo Andrea M. 
Published: March 2024

Background
Despite significant cardiac involvement in sarcoidosis, real‐world data on death due to cardiovascular disease among patients with sarcoidosis is not well established.

Methods and Results
We queried the Centers for Disease Control and Prevention's Wide‐Ranging Online Data for Epidemiologic Research database for data on patients with sarcoidosis aged ≥25 years from 1999 to 2020. Diseases of the circulatory system except ischemic heart disease were listed as the underlying cause of death, and sarcoidosis was stated as a contributing cause of death. We calculated age‐adjusted mortality rate (AAMR) per 1 million individuals and determined the trends over time by estimating the annual percentage change using the Joinpoint Regression Program. Subgroup analyses were performed on the basis of demographic and geographic factors. In the 22‐year study period, 3301 cardiovascular deaths with comorbid sarcoidosis were identified. The AAMR from cardiovascular deaths with comorbid sarcoidosis increased from 0.53 (95% CI, 0.43–0.65) per 1 million individuals in 1999 to 0.87 (95% CI, 0.75–0.98) per 1 million individuals in 2020. Overall, women recorded a higher AAMR compared with men (0.77 [95% CI, 0.74–0.81] versus 0.58 [95% CI, 0.55–0.62]). People with Black ancestry had higher AAMR than people with White ancestry (3.23 [95% CI, 3.07–3.39] versus 0.39 [95% CI, 0.37–0.41]). A higher percentage of death was seen in the age groups of 55 to 64 years in men (23.11%) and women (21.81%), respectively. In terms of US census regions, the South region has the highest AAMR from cardiovascular deaths with comorbid sarcoidosis compared with other regions (0.78 [95% CI, 0.74–0.82]).

Conclusions
The increase of AAMR from cardiovascular deaths with comorbid sarcoidosis and higher cardiovascular mortality rates among adults aged 55 to 64 years highlight the importance of early screening for cardiovascular diseases among patients with sarcoidosis.
OneMax Is Not the Easiest Function for Fitness Improvements
Authors: Kaufmann Marc , Larcher Maxime , Lengler Johannes , Zou Xun 
Published: March 2024

Abstract
We study the (1:s+1) success rule for controlling the population size of the (1,λ)-EA. It was shown by Hevia Fajardo and Sudholt that this parameter control mechanism can run into problems for large s if the fitness landscape is too easy. They conjectured that this problem is worst for the OneMax benchmark, since in some well-established sense OneMax is known to be the easiest fitness landscape. In this paper, we disprove this conjecture. We show that there exist s and ɛ such that the self-adjusting (1,λ)-EA with the (1:s+1)-rule optimizes OneMax efficiently when started with ɛn zero-bits, but does not find the optimum in polynomial time on Dynamic BinVal. Hence, we show that there are landscapes where the problem of the (1:s+1)-rule for controlling the population size of the (1,λ)-EA is more severe than for OneMax. The key insight is that, while OneMax is the easiest function for decreasing the distance to the optimum, it is not the easiest fitness landscape with respect to finding fitness-improving steps.
The Spiraling Cognitive–Emotional Brain: Combinatorial, Reciprocal, and Reentrant Macro-organization
Authors: Pessoa Luiz 
Published: March 2024

Abstract
This article proposes a framework for understanding the macro-scale organization of anatomical pathways in the mammalian brain. The architecture supports flexible behavioral decisions across a spectrum of spatiotemporal scales. The proposal emphasizes the combinatorial, reciprocal, and reentrant connectivity—called CRR neuroarchitecture—between cortical, BG, thalamic, amygdala, hypothalamic, and brainstem circuits. Thalamic nuclei, especially midline/intralaminar nuclei, are proposed to act as hubs routing the flow of signals between noncortical areas and pFC. The hypothalamus also participates in multiregion circuits via its connections with cortex and thalamus. At slower timescales, long-range behaviors integrate signals across levels of the neuroaxis. At fast timescales, parallel engagement of pathways allows urgent behaviors while retaining flexibility. Overall, the proposed architecture enables context-dependent, adaptive behaviors spanning proximate to distant spatiotemporal scales. The framework promotes an integrative perspective and a distributed, heterarchical view of brain function.
Diet variations across remote populations of a widely distributed snake species, the Asp viper (Vipera aspis aspis, Linnaeus, 1758)
Authors: Laurence Florian , Bonnet Xavier , Ursenbacher Sylvain , Guiller Gaetan , Billy Gopal , Naulleau Guy , Vidal Nicolas 
Published: March 2024

Abstract
Documenting intra-specific diet variations among remote populations, thus across different habitats, is important to address evolutionary (e.g., phenotypic plasticity) and conservation issues (e.g., capacity to adapt to changing prey availability). We compared the diet of different populations of Asp vipers (Vipera aspis aspis; Linnaeus, 1758) living in contrasted habitats of France and Switzerland. We sampled 1680 individuals in five geographical areas, broadly encompassing the distribution range of the species (West to East and North to South): Group 1 = Western Central France; Group 2 = Central France; Group 3 = West France; Group 4 = South France, and Group 5 = Switzerland. We compared mean total body size (TL) of snakes and their diet. We found strong similarities among the groups with a predominance of micromammals in the diet. In mountainous area (Group 5), however, snakes included a substantial number of reptiles and fed occasionally on amphibians and birds. The diet varied ontogenetically (juveniles often consuming lizards, adults heavily feeding on mammals) and sexually (females tending to feed more extensively on mammals). Overall, our results suggest that Asp vipers maintain a diet largely based on micromammals (mostly voles), at least across their continental distribution range.
Efficacy of Theta Burst Stimulation in Bipolar Depression: A Systematic Review and Meta-analysis
Authors: Malik Gunjan , Mishra Preeti , Godi Sangha Mitra , Garg Shobit , Tikka Sai Krishna 
Published: March 2024

Purpose: Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative therapeutic modality for bipolar depression. Theta Burst Stimulation (TBS) a novel variant of rTMS is currently evolving as an effective and safe therapeutic tool in the management of bipolar depression, although it is still in the initial phase. In the present systematic review and meta-analysis, data from various studies investigating the effectiveness and tolerability of TBS in individuals with bipolar depression were synthesized. Data collection and analyses: Eight studies assessing the efficacy of TBS as a treatment for bipolar depression were included after a systematic search. The quality of the included studies was assessed using standard methods. Synthesized data included three uncontrolled clinical trials (non-randomized controlled trials [RCTs]; n = 48) and five RCTs ( n = 201). While four studies used intermittent TBS, two studies used continuous TBS and bilateral TBS, each. Data from the five RCTs meta-analyzed using the random effects model showed the pooled odds ratio and effect size for response in the active group compared to the sham group were 1.01 (95%CI: 0.56, 1.83) and 1.64 (95%CI: –0.46, 3.74), respectively. Although both models showed no/minimal heterogeneity or publication bias, they were not statistically significant. A supplementary trial sequential analysis confirmed the need for more studies and suggested that the total sample required for drawing meaningful inferences was 918 samples. Conclusion: The available evidence suggests that more studies are required to draw conclusive inferences for the efficacy of TBS in the therapeutic management of bipolar depression.
Study on the clinical and electrophysiological characteristics of nerve function in myasthenia gravis patients in Vietnam
Authors: Anh Pham Tho Kieu , Van Pham Phuong , Dinh Le Tung , Thanh Nguyen Binh , Kien Nguyen Trung , Thanh Tran Tam Thai , Hai Nguyen Sam Phan , Van Le Minh 
Published: March 2024

Background: In Vietnam, there is limited research on the role of nerve conduction in myasthenia gravis and its association with clinical features. Objective: This study aims to describe the electrophysiological features in patients with myasthenia gravis. Methods: This descriptive study was conducted from September 2019 to December 2021. The study included 33 myasthenia gravis patients who sought medical consultation or received inpatient treatment during this period. The Myasthenia Gravis Foundation of America classifies myasthenia gravis into five groups: I, IIa, IIb, IIIa, IIIb, IVa, IVb, and V. Notably, Group I involves pure ocular weakness, whereas Group a primarily impacts limb and axial muscles, and Group b mainly affects bulbar and respiratory muscles. Results: The study revealed that motor and sensory nerve conduction in the upper and lower limbs were within normal limits for the patient group under evaluation. Repetitive nerve stimulation testing at a frequency of 3 Hz showed positive results in 66.7% of myasthenia gravis patients. Myasthenia gravis patients displayed distinct clinical symptoms, with ptosis being the most common (87.9%). Myasthenia Gravis Foundation of America classification indicated the highest proportion in subgroup IIa (24.2%), with myasthenia gravis predominating in limb and axial muscles (Group a) observed in 51.5% of cases. Needle electromyography showed no abnormalities in myasthenia gravis patients. There was an association between acetylcholine receptor antibody titers and the results of the 3 Hz repetitive nerve stimulation test in myasthenia gravis patients, with a significance of p = 0.002. Conclusion: Nerve conduction studies should be performed in patients with suspected neuromuscular disorders to aid in differential diagnosis and definitive diagnosis of myasthenia gravis.
Impact of race and social determinants of health on outcomes in patients with aggressive B-cell NHL treated with CAR-T therapy
Authors: Karmali Reem , Machhi Rushad , Epperla Narendranath , Shouse Geoffrey , Romancik Jason , Moyo Tamara K. , Kenkre Vaishalee , Ollila Thomas A. , Fitzgerald Lindsey , Hess Brian , David Kevin , Roy Ishan , Zurko Joanna , Chowdhury Sayan Mullick , Annunzio Kaitlin , Ferdman Robert , Bhansali Rahul S. , Harris Elyse I. , Liu Jieqi , Nizamuddin Imran , Ma Shuo , Moreira Jonathan , Winter Jane , Pro Barbara , Stephens Deborah M. , Danilov Alexey , Shah Nirav N. , Cohen Jonathon B. , Barta Stefan K. , Torka Pallawi , Gordon Leo I. 
Published: March 2024

Abstract
Chimeric antigen receptor (CAR) T-cell (CAR-T) immunotherapy is an effective therapy for relapsed/refractory B-cell non-Hodgkin lymphoma (r/r B-NHL). However, data are limited on the impact of the convergence of race and social determinants of health on outcomes for patients treated with CAR-T therapy. We examined the impact of interactions between race and insurance type on health care use and outcomes in patients treated with CAR-T therapy for aggressive B-NHL. Adult patients with r/r B-NHL treated with CD19 CAR-Ts were identified between 2015 and 2021 across 13 US academic centers. Insurance type, demographic, and clinical data were collected and analyzed. In total, 466 adult patients were included in our analysis. Median follow-up after CAR-T therapy was 12.7 months. Median progression-free survival (mPFS) was longer for Caucasians (11.5 months) than for African Americans (3.5 months; hazard ratio [HR], 1.56 [1.03-2.4]; P = .04) or Asians (2.7 months; HR, 1.7 [1.02-2.67]; P = .04). Differences in median overall survival (mOS) were not significant. For Medicare (n = 206) vs Medicaid (n = 33) vs private insurance (n = 219) vs self-pay (n = 7): mPFS was 15.9 vs 4.2 vs 6.0 vs 0.9 months (P &lt; .001), respectively; and mOS was 31.2 vs 12.8 vs 21.5 vs 3.2 months (P &lt; .001), respectively. Our multicenter retrospective analysis showed that race and insurance status can affect outcomes for patients treated with CAR-T therapy.
Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer
Authors: Xiang Shasha , Yan Wen , Ren Xing , Feng Jianbo , Zu Xuyu 
Published: March 2024

AbstractFerroptosis, a therapeutic strategy for tumours, is a regulated cell death characterised by the increased accumulation of iron-dependent lipid peroxides (LPO). Tumour-associated long non-coding RNAs (lncRNAs), when combined with traditional anti-cancer medicines or radiotherapy, can improve efficacy and decrease mortality in cancer. Investigating the role of ferroptosis-related lncRNAs may help strategise new therapeutic options for breast cancer (BC). Herein, we briefly discuss the genes and pathways of ferroptosis involved in iron and reactive oxygen species (ROS) metabolism, including the XC−/GSH/GPX4 system, ACSL4/LPCAT3/15-LOX and FSP1/CoQ10/NAD(P)H pathways, and investigate the correlation between ferroptosis and LncRNA in BC to determine possible biomarkers related to ferroptosis.
Functional diversity and secondary production of macrofaunal assemblages can provide insights of biodiversity-ecosystem function relationships
Authors: Wang Zhe , Xu Jing , Xu Zhaodong , Liu Xiaoshou 
Published: March 2024

Abstract
Background
Semi-enclosed bays are important links in the material cycle and energy flow between terrestrial and marine ecosystems. They are also areas of intense human activities and heavily influenced by such activities as aquaculture, industrial and agricultural wastewater discharge. The rate of biodiversity loss and changes in ecosystems have prompted research into the relationship between species diversity and ecosystem functioning. Studies have shown that application of functional diversity indices is useful for assessing the status of ecosystem functioning. We quantitatively sampled macrofauna in a semi-enclosed bay in four seasons and analyzed the relationship between species, functional diversity and secondary production, biomass and feeding functional groups of macrofauna.

Results
The annual secondary production was 325.01 kJ m−2 year−1. Detritivorous, carnivorous and planktophagous feeders were the main functional groups of macrofauna. Differences in the spatial–temporal distribution of functional groups were influenced by Ruditapes philippinarum and Hemileucon bidentatus. Functional richness had significant negative correlations with macrofaunal biomass and secondary production. Functional divergence, functional dispersion and Rao's quadratic entropy had highly significant negative correlations with macrofaunal biomass and secondary production.

Conclusion
The results showed that high overlap of ecological niches can increase competition for habitat resources, leading to a decline in biomass and secondary production. In addition, aquaculture could promote the use of habitat resources to some extent, while it could increase competition for ecosystem resources (including habitat resources, atmospheric resources, water resources, etc.). Functional diversity is a good indicator for the ecosystem functioning and the competition status for habitat resources, which can provide insights into the current state of ecosystem function.
Immune system modulation & virus transmission during parasitism identified by multi-species transcriptomics of a declining insect biocontrol system
Authors: Inwood Sarah N. , Harrop Thomas W. R. , Shields Morgan W. , Goldson Stephen L. , Dearden Peter K. 
Published: March 2024

Abstract
Background
The Argentine stem weevil (ASW, Listronotus bonariensis) is a significant pasture pest in Aotearoa New Zealand, primarily controlled by the parasitoid biocontrol agent Microctonus hyperodae. Despite providing effective control of ASW soon after release, M. hyperodae parasitism rates have since declined significantly, with ASW hypothesised to have evolved resistance to its biocontrol agent. While the parasitism arsenal of M. hyperodae has previously been investigated, revealing many venom components and an exogenous novel DNA virus Microctonus hyperodae filamentous virus (MhFV), the effects of said arsenal on gene expression in ASW during parasitism have not been examined. In this study, we performed a multi-species transcriptomic analysis to investigate the biology of ASW parasitism by M. hyperodae, as well as the decline in efficacy of this biocontrol system.

Results
The transcriptomic response of ASW to parasitism by M. hyperodae involves modulation of the weevil’s innate immune system, flight muscle components, and lipid and glucose metabolism. The multispecies approach also revealed continued expression of venom components in parasitised ASW, as well as the transmission of MhFV to weevils during parasitism and some interrupted parasitism attempts. Transcriptomics did not detect a clear indication of parasitoid avoidance or other mechanisms to explain biocontrol decline.

Conclusions
This study has expanded our understanding of interactions between M. hyperodae and ASW in a biocontrol system of critical importance to Aotearoa-New Zealand’s agricultural economy. Transmission of MhFV to ASW during successful and interrupted parasitism attempts may link to a premature mortality phenomenon in ASW, hypothesised to be a result of a toxin-antitoxin system. Further research into MhFV and its potential role in ASW premature mortality is required to explore whether manipulation of this viral infection has the potential to increase biocontrol efficacy in future.
Reproductive factors and risk of lung cancer among 300,000 Chinese female never-smokers: evidence from the China Kadoorie Biobank study
Authors: Elbasheer Marwa M. A. , Bohrmann Bastian , Chen Yiping , Lv Jun , Sun Dianjianyi , Wu Xia , Yang Xiaoming , Avery Daniel , Li Liming , Chen Zhengming , Kartsonaki Christiana , Chan Ka Hung , Yang Ling 
Published: March 2024

Abstract
Background
Lung cancer is the leading cause of cancer mortality among Chinese females despite the low smoking prevalence among this population. This study assessed the roles of reproductive factors in lung cancer development among Chinese female never-smokers.

Methods
The prospective China Kadoorie Biobank (CKB) recruited over 0.5 million Chinese adults (0.3 million females) from 10 geographical areas in China in 2004–2008 when information on socio-demographic/lifestyle/environmental factors, physical measurements, medical history, and reproductive history collected through interviewer-administered questionnaires. Cox proportional hazard regression was used to estimate adjusted hazard ratios (HRs) of lung cancer by reproductive factors. Subgroup analyses by menopausal status, birth year, and geographical region were performed.

Results
During a median follow-up of 11 years, 2,284 incident lung cancers occurred among 282,558 female never-smokers. Ever oral contraceptive use was associated with a higher risk of lung cancer (HR = 1.16, 95% CI: 1.02–1.33) with a significant increasing trend associated with longer duration of use (p-trend = 0.03). Longer average breastfeeding duration per child was associated with a decreased risk (0.86, 0.78–0.95) for > 12 months compared with those who breastfed for 7–12 months. No statistically significant association was detected between other reproductive factors and lung cancer risk.

Conclusion
Oral contraceptive use was associated with an increased risk of lung cancer in Chinese female never-smokers. Further studies are needed to assess lung cancer risk related to different types of oral contraceptives in similar populations.
Retinal injury from a laser skin resurfacing device during medical tourism: a public health concern
Authors: Lambert Lester H. , Tompkins Brett L. , Uber Ian C. , Kapoor Kapil G. , Ramsey David J. 
Published: March 2024

Abstract
Background
Laser skin resurfacing is a popular cosmetic procedure for noninvasive skin rejuvenation. Since health insurance plans often do not cover these types of procedures, patients often pay out of pocket. Consequently, there is an incentive to go abroad, where prices are more affordable. However, practitioners in destination countries may lack rigorous training on laser safety, regulatory oversight, or licensing, especially on devices used for “cosmetic” procedures. In certain cases, this can lead to tragic outcomes, especially when underqualified practitioners operate medical-grade laser devices.

Case presentation
A 29-year-old woman suffered a retinal burn from a handheld Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser pulse device used to perform skin resurfacing treatment at a medical spa in Vietnam. The patient was not adequately informed about the potential risk to her vision and was not provided with any eye protection. A momentary, unintended laser exposure to the patient’s right eye led to irreversible vision loss due to a macular burn. This incident caused immediate pain, followed by the sudden appearance of floaters, along with a retinal and vitreous hemorrhage. Despite treatment with off-label bevacizumab for the development of a choroidal neovascular membrane, vision remained at the level of counting fingers because of the presence of the macular scar.

Conclusion
When utilizing laser-based devices, it is crucial to employ safety measures, such as the wearing of safety goggles or the use of eye shields to protect ocular tissues from potential damage. The growing availability of cosmetic laser devices presents a substantial public health risk, because numerous operators lack adequate training in essential safety standards, or they neglect to follow them. Furthermore, patients seeking services abroad are subject to the regulatory practices of the destination country, which may not always enforce the requisite safety standards. Further research is needed to determine regional and global incidence of laser-related injuries to help direct educational and regulatory efforts.
Long-term real-life outcomes of the Clareon® hydrophobic intraocular lens: the Clarte study in 191 eyes
Authors: Bouvarel Hugo , Agard Emilie , Billant Jérémy , Levron Antoine , Chudzinski Roman , Plas Hélène , Bernier Raphaël , Sejournet Lucas , Chaperon Mayeul , Dot Corinne 
Published: March 2024

Abstract
Background
To describe and analyze the real-life refractive, functional and safety outcomes of the Clareon® intraocular lens (IOL) after 3 years.

Methods
Data was collected retrospectively for observational purposes between July 2017 and December 2019 in the ophthalmology department of Desgenettes military hospital in Lyon, France. Eyes that underwent cataract surgery with Claeron® implantation were consecutively included. Patients with a systemic or ocular condition that could affect the visual outcome were excluded. Postoperative corrected (CDVA) and uncorrected (UDVA) distance visual acuities as well as capsule and IOL transparency were assessed at 1 month and 3 years.

Results
A total of 326 eyes were analyzed at one month and 191 eyes were reassessed at the 3-year follow-up visit. At 3 years, the mean CDVA was 0.003 LogMAR (95% confidence interval [CI]: -0.003 to -0.01) and the mean UDVA was 0.075 (95% CI: 0.054 to 0.095). Three quarters of the patients had an UDVA ≥ 0.097 logMAR (20/25 Snellen equivalent) and 50% had an UDVA ≥ 0 (20/20). The absence of glistening was reported in 95.3% of cases and 4.7% [9] of patients experienced a clinically significant posterior capsular opacification (PCO) for which Nd:YAG treatment was required.

Conclusions
This real-life study reports high-performance and stable long-term refractive outcomes of the Clareon® IOL with good safety in terms of PCO and glistening.