bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adverse fetal outcomes and associated factors among mothers of advanced age at a tertiary hospital, Southwestern Uganda: a cross-sectional study
Authors: Masembe Sezalio , Migisha Richard , Turyasingura Godwin , Aheisibwe Hillary , Lule John Crysistom 
Published: March 2024

Abstract
Background: Pregnancies among mothers of advanced age (≥35 years) are inherently associated with poor fetal outcomes. In this study, we determined the proportion of adverse fetal outcomes and identified associated factors among pregnant mothers of advanced age who delivered at Kabale Regional Referral Hospital (KRRH) in Southwestern Uganda.
Methods: We conducted a cross-sectional study at KRRH’s Maternity Ward from March to August 2023. We enrolled post-delivery mothers aged ≥35 years. We collected data on socio-demographic, obstetric, and medical characteristics, as well as fetal outcomes, using interviewer-administered structured questionnaires. We defined an adverse fetal outcome as the occurrence of any of the following complications: early neonatal death, preterm birth, congenital anomalies, macrosomia, low APGAR score, or low birth weight, sustained by the fetus or neonate during pregnancy, delivery, or the immediate post-delivery period before discharge from the hospital. We performed multivariable logistic regression to identify factors associated with adverse fetal outcomes.
Results: We enrolled 417 participants, of whom 206 (49.4%) were aged 35-37 years. The majority (n=273; 65.5%) were multiparous (parity ≥5). Adverse fetal outcomes occurred in 8.4% (n=36; 95% CI: 6.1-11.5%) of participants, with early neonatal death being the most common (3.6%), followed by low birth weight (2.4%), congenital anomalies (2.6%), macrosomia (1.4%), low APGAR score (1.4%), and preterm birth (1.2%). Prolonged labor (adjusted odds ratio [aOR]=3.71, 95% CI: 1.40-9.85) and a history of abortion (aOR=2.56, 95% CI: 1.17-5.60) were significantly associated with adverse fetal outcomes.
Conclusion: Approximately 1 out of every 10 advanced-aged mothers surveyed experienced a poor fetal outcome, with mothers who had prolonged labor or history of abortions having increased odds of the poor fetal outcomes. Close monitoring during pregnancy and neonatal care preparedness among mothers of advanced age especially those with prolonged labour and history of abortion could mitigate risks of adverse fetal outcomes in this study population.
A robot intelligent polishing system for fiber reinforced plastics (FRP) material combined with online measurement
Authors: Yang Ping , Yang Bingya , Wu Runxi 
Published: March 2024

Abstract
Fiber Reinforced Plastics (FRP) are extensively employed in the fabrication of mannequins. However, the manual polishing process of FRP is characterized by a deficiency in efficiency and poses detrimental effects on the workforce. An industrial robot combined with an online measurement method is proposed for polishing the surface of the mannequin arm made of FPR material. In this paper, the factors affecting the removal depth of FRP materials are discussed by establishing a mathematical model. Based on the simulation analysis, the removal depth and the range of machining parameters are derived. The online measuring device manufactured by Keyence model LJ-X8200 is mounted on the flange of an ABB IRB6700 industrial robot, which obtains the 3D digital data from arm surface before and after the polishing process. A sub-regional hand-eye calibration is applied to establish the spatial transformation matrix from the sensor coordinate to the workpiece coordinate to refine the calibration range and accuracy. Then, the processing data points are extracted by equal interval and coplanar method. In addition, the robot processing posture is obtained from the surface fitting curve based on the least square method. Finally, the polishing processing experiments are performed to analyze robot intelligent location recognition and verify the surface removal effect based on the optimum polishing parameters. Comparing the 3D measuring data before and after the polishing process, it is shown that the average value of workpiece surface roughness has been reduced to 2.518µm.
Analysis of the efficacy of multidisciplinary integration based on 3D reconstruction technology for the treatment of gout stone
Authors: Zhou Shizhe , Zhang Zengxiao , Liu Tian , Yang Min , Ma Lidan , Cheng Xiaoyu , Sun Ruixia , Xu Yijun , Ning Chunping , Li Changgui , Pan Yuehai , Chen Ying 
Published: March 2024

Abstract
Objective:
This study investigates the efficacy of multidisciplinary fusion therapy based on 3D reconstruction technology for the treatment of gouty stone by comparing the efficacy of multidisciplinary fusion therapy with pharmacologic therapy.
Methods:
This study is a cohort study.Patients who underwent gout stone surgery at the Affiliated Hospital of Qingdao University from November 2020 to November 2022 were included in this study, totaling 85 to form the MDT surgery group, and matched among gout stone patients in the outpatient clinic during the same period to form the medication group. Patients in the 2 groups were followed up for 6 months to compare baseline and follow-up data.
Results:
Both groups experienced a decrease in uric acid levels and an increase in SF-36 scores during follow-up. After adjusting for confounders, multifactorial logistic regression showed that the uric acid attainment rate of patients in the MDT surgery group was 4.011 times higher than that of the drug group (OR: 4.011, 95% CI: 1.595, 10.086, P = 0.003); the proportion of patients with an increase in SF-36 in the MDT surgery group was 4.976 times higher than that of the drug group (OR: 4.976, 95% CI : 2.243, 11.040, P < 0.001); the proportion of patients treated with high-dose medication in the MDT surgery group was 1.8% of that of patients in the drug group (OR: 0.018, 95% CI: 0.002, 0.148, P < 0.001); and the proportion of patients in the MDT surgery group who developed frequent gout was 2.8% of that in the drug group (OR: 0.028 95% CI: 0.003, 0.2398, P = 0.001). the proportion of patients in the MDT surgery group who developed abnormal liver function was 0.317 times higher than that in the drug group (OR: 0.317, 95% CI: 0.121, 0.831, P = 0.019).
Conclusion:
The multidisciplinary integration of 3D reconstructive techniques for gout stone treatment resulted in an increase in uric acid compliance, a decrease in the frequency of gout and the appearance of liver impairment; and a greater benefit in terms of improvement in the quality of life of the patients after treatment.
Advancing Targeted Combination Chemotherapy in Triple Negative Breast Cancer: Nucleolin Aptamer-Mediated Controlled Drug Release
Authors: MA Yuan , Xie Duoli , Shen Xinyang , Wu Xiaoqiu , Pan Yufei , Chen Zefeng , Li Fangfei , Lu Aiping , Zhang Ge 
Published: March 2024

Abstract

Triple negative breast cancer (TNBC) poses a significant challenge due to its aggressive nature and limited treatment options. While scheduled treatment with paclitaxel and fluorouracil has shown efficacy, their uncontrolled distribution remains challenging. To address this issue, we designed a dual chemo-loaded aptamer with redox-sensitive caged paclitaxel for rapid release and non-cleavable caged fluorouracil for slow release. The nucleolin aptamer significantly improved tumor-targeting, enhancing the effectiveness of the conjugated drugs in TNBC cells. Through nucleolin-mediated endocytosis, the drugs achieved scheduled release, resulting in improved antitumor activity and reduced toxicity in vitro and in vivo. These findings offer new possibilities for developing targeted combination chemotherapy in TNBC.
Identification and validation of tumor-specific T cell receptors from tumor infiltrating lymphocytes using tumor organoid co-cultures
Authors: Li Zhilang , Ma Lisha , Gao Zhaoya , Wang Xiya , Che Xuan , Zhang Pengchong , Li Yixian , Zhang Qianjing , Liu Tianxing , Sun Yuan , bai yun , Deng Hong-kui 
Published: March 2024

Abstract
T cell receptor-engineered T cells (TCR-Ts) therapy is promising for cancer immunotherapy. Most studies have focused on identifying tumor-specific T cell receptors (TCRs) through predicted tumor neoantigens. However, current prediction algorithms for tumor neoantigens are not reliable and many tumor neoantigens are derive from non-coding regions. Thus, the technological platform for identifying tumor-specific TCRs using natural antigens expressed on tumor cells is urgently need. In this study, tumor organoids-enriched tumor infiltrating lymphocytes (oeT) were obtained by repeatedly stimulating of autologous patient-derived organoids (PDO) in vitro. The oeT cells specifically responded to autologous tumor PDO by detecting CD137 expression and the secretion of IFN-γ using enzyme-linked immunospot (ELISPOT) assay. The measurement of oeT cell-mediated killing of three-dimensional organoids was conducted using a caspase3/7 flow cytometry assay kit. Subsequently, tumor-specific T cells were isolated based on CD137 expression and their TCRs were identified through single-cell RT-PCR analysis. The specificity cytotoxic of TCRs were confirmed by transferring to primary peripheral blood T cells. The co-culture system proved highly effective in generating CD8 + tumor-specific oeT cells. These oeT cells effectively induced IFN-γ secretion and exhibited specificity in killing autologous tumor organoids, while not eliciting a cytotoxic response against normal organoids. The analysis conducted by TCRs revealed a significant expansion of T cells within a specific subset of TCRs. Subsequently, the TCRs were cloned and transferred to peripheral blood T cells generation engineered TCR-Ts, which adequately recognized and killed tumor cell in a patient-specific manner. The co-culture system provided an approach to generate tumor-specific TCRs from tumor-infiltrating lymphocytes (TILs) of patients with colorectal cancer (CRC), and tumor-specific TCRs can potentially be used for personalized TCR-Ts therapy.
Causal relationship between immune cells and Osteonecrosis: a bidirectional Mendelian randomization study
Authors: meng Chen , Qi Baochuang , Luo Huan , Tang Zhifang , Ren Junxiao , Shi Hongxin , Li Chuan , Xu Yongqing 
Published: March 2024

Abstract
Objectives
Research indicates a close association between aberrant immune reactions in osteonecrotic tissues and immune cell infiltration, yet the causal relationship between them remains elusive. We aim to determine whether a causality exists between immune cell infiltration and osteonecrosis.
Methods
A comprehensive Mendelian Randomization (MR) analysis was conducted to determine the causal relationship between immune cell characteristics and osteonecrosis in this study. Utilizing publicly available genetic data, we explored the causal relationships between 731 immune cell features and 604 cases from the FinnGen Finnish database, as well as 257 cases from the UK Biobank database with osteonecrosis data. The inverse-variance weighted (IVW) method was used for the primary analysis, and we employed sensitivity analyses to assess the robustness of the main results. Additionally, meta-analysis was performed on significantly associated immune cells with osteonecrosis outcomes (False Discovery Rate FDR < 0.05).
Results
By leveraging bidirectional MR, we revealed that 11 cell types exhibited a significantly associated (FDR < 0.05) association with the potential to either increase or decrease the risk of osteonecrosis. The occurrence and progression of osteonecrosis were found to have a significant causal relationship with the increase or decrease in six immune cell types (FDR < 0.05). Meta-analysis was conducted on the differential results between the FinnGen and UK Biobank datasets. Ultimately, CD20-% lymphocytes, CD62L- monocyte % monocytes, CD33br HLA DR + CD14- % CD33br HLA DR+, EM CD4 + activated cells and DP (CD4 + CD8+) % T cells were identified to increase or decrease the odds of osteonecrosis. Notably, osteonecrosis was associated with a potential decrease in CD45 on immature MDSC cell content.
Conclusion
From a genetic perspective, we demonstrated a close association between immune cells and osteonecrosis. These findings significantly enhance our understanding of the interplay between immune cell infiltration and the risk of osteonecrosis, contributing to the potential design of therapeutic strategies from an immunological standpoint.
Global Existence for an Isotropic Landau Model
Authors: Bowman David , Ji Sehyun 
Published: March 2024

Abstract

Following the recent ideas of Guillen and Silvestre, we prove that the Fisher information is non-increasing along the flow of the isotropic Landau equation. We then use this fact to deduce global existence for the equation ∂tf = (−∆)−1f · ∆f + f2 under a relatively lax set of conditions on the initial data. In particular, we remove the restrictive radially decreasing assumption of previous works.
Perception of patients’ rights in clinical services among clients attending the outpatient department at the Mawenzi Regional Referral Hospital, Tanzania
Authors: Ernest Bahat , Ochieng Joseph , Kwagala Betty 
Published: March 2024

Abstract
Background: Ethical principles and patients’ rights should guide all encounters with patients. Failure to observe ethical guidelines can lead to patient dissatisfaction and medical malpractice, and without an appropriate understanding of the patient’s rights, the healthcare team may at times be prone to various tendencies, such as failure to respect patient autonomy, such as acting in a paternalist manner or making clinical decisions on behalf of the patient or family. Another way to do so can occur, including in cases in which not all options, risks, or side effects may be appropriately disclosed. This study explored the perceptions of patients’ rights to clinical services among clients attending the outpatient department at the Mawenzi Regional Referral Hospital.
Methods: This was an exploratory, cross-sectional study design that employed qualitative methods for data collection. The study was carried out among 34 clients attending the outpatient department at Mawenzi Regional Referral Hospital in the Kilimanjaro region of Tanzania: the medical unit, the Care and Treatment Clinic (CTC) unit, the gynaecology unit, and the TB and leprosy unit. In-depth interviews were conducted with 20 participants, while 14 participants participated in group discussions. The data were analysed via inductive thematic analysis, which allowed the data to identify and determine the themes in this study, which were then presented in the form of extracts or quotes. Nvivo 12 software was used to support the data analysis.
Results: The majority of the participants perceived that patients' rights were well implemented in health facilities and that they were satisfied with them. The minority stated that they are not satisfied with patients' rights because of various challenges that cause their rights to be poorly implemented. The main reasons for the poor implementation and dissatisfaction suggested were corruption in health facilities, the beating of patients, wastage of time while in health care facilities, poor communication with some health care providers, a shortage of medical equipment and healthcare providers, gaps in existing regulations, and follow-up.
Conclusion: To enhance satisfaction with patients' rights, there is a need for more sensitization of patients' rights through the client's service charter for health facilities and a relevant health policy to guide the implementation of patients' rights.
Exploring Gravitational Potential and Velocity Profiles through Hypergeometric and Bessel Functions
Authors: Qadri Durakhshan Ashraf , Hameeda Mir , Gani Qudsia , Rocca M. C. 
Published: March 2024

Abstract
This paper explores the behavior of gravitational potential in the form of Bessel functions and Hypergeo-metric functions[1, 2, 3]. Building upon our earlier research[4, 5] on gravitational potential characterized by Bessel functions[6], we now investigate the gravitational potential as a hypergeometric function. Through various examples and formulations, including Newton’s gravity and Tohline’s gravity[7], we present various forms of gravitational potential and velocity profiles as hypergeometric functions. Additionally, we discuss the combination of the homogeneous hypergeometric solution with the homogeneous Bessel solution, along with Newton’s gravity and Tohline’s gravity. Finally, we present an oscillatory model incorporating both the hypergeometric function and the Bessel function, combined with the Newton potential or the Tohline potential to observe the quantized behavior of speed. To further lend credence to this study and previous work, the authors have proposed a possible interpretation of neutrino oscillations while using the same functional form of gravitational potential as obtained in this paper. Neutrinos have a feeble mass and interact via gravity. These flip their flavour during the course of their flight which is called as neutrino oscillation. So far neutrino oscillation has been described as quantum mechanical phenomenon which arises since the mass eigenstates of neutrinos are not identical with their flavour eigenstates. However, an alternate classical description may be that neutrinos oscillate due to oscillatory nature of gravitational potential.
Transmural healing is not associated with less disability than complete endoscopic mucosal healing: a prospective study in a patient with Crohn's disease
Authors: Yzet Clara , Brazier Franck , Hautefeuille Vincent , Grados Lucien , Richard Nicolas , Decrombecque Catherine , Diouf Momar , Fumery Mathurin 
Published: March 2024

Abstract
Introduction:
Crohn's disease (CD) is associated with disability by affecting physical and emotional well-being, and by altering social interactions. The impact of transmural healing on disability is currently unknown.
Methods
We conducted a monocentric cross-sectional study. Patients followed for CD in endoscopic remission (CDEIS < 4) underwent within < 4 weeks an intestinal ultrasound (IUS) and a disability assessment by an IBD-disk and were consecutively included. Four groups were considered: (A) transmural healing defined by the combination of complete endoscopic healing (CDEIS = 0) and ultrasound healing (bowel wall thickness (BWT) less than 3 mm), (B) complete endoscopic healing, (C) ultrasound healing and (D) Partial healing. Moderate to severe disability was defined as an overall score ≥ 40.
Results
A total of 85 patients were included. Forty-four (51.7%) were female, the median age and disease duration were 38 years ([IQR], 33–44) and 12.0 years (IQR, 5–20). The median global IBD-Disk score was 25 (IQR, 9–41) and 24 patients (28.2%) had moderate to severe disability. Transmural healing (group A) was observed in 40 patients (47.1%). Moderate to severe disability was identified in 17.5% (7/40) of patients with transmural healing, 25% (4/16) with endoscopic healing, 44.4% (8/18) with ultrasound healing and 45.4% (5/11) without healing. There was no difference in terms of severe disability between patients with transmural healing and complete endoscopic healing (group B versus A OR = 1.5 95% CI [0.3, 6.2], p = 0.525)
Conclusions
Transmural healing did not provide any benefit in terms of disability compared to complete endoscopic healing.
Multi-player quantum data hiding by nonlocal quantum state ensembles
Authors: Kim Jeong San , Ha Donghoon 
Published: March 2024

Abstract
We provide multi-player quantum data hiding based on nonlocal quantum state ensembles arising from multi-party quantum state discrimination.
Using bounds on local minimum-error discrimination of multi-party quantum states, we construct a multi-player quantum data-hiding scheme.
Our data-hiding scheme can be used to hide multiple bits, asymptotically, unless all the players collaborate.
We also illustrate our results by examples of nonlocal quantum state ensembles.
An Approximation algorithm for the combination of G-variational inequality and fixed point problems
Authors: Kheawborisut Araya , Kangtunyakarn Atid 
Published: March 2024

Abstract
In this paper, we introduce a new problem is called the combination of G-variational inequality problem in a Hilbert space endowed with graphs and an iterative scheme to find a common element of the set of fixed points of a G-nonexpansive mapping and the solution set of the proposed problem. Under suitable assumptions, a strong convergence theorem has been proved in the framework of a Hilbert space endowed with graphs. Applying our main result, we solve the G-minimization problem. We also give examples to support our main results. Mathematics Subject Classification (2010). 47H09, 47H10, 90C99. Keywords. the combination of G-variational inequality problems, fixed point problem, G-inverse strongly monotone mapping.
Mathematics Subject Classification (2010). 47H09, 47H10, 90C99.
Optical Properties of Eu 3+ doped CaSiO 3 Phosphors
Authors: Rao Ch. Atchyutha , Murthy K. V.R. 
Published: March 2024

Abstract
Optical properties of Eu3+ doped CaSiO3 Phosphor were synthesized using the conventional Solid-State Reaction (SSR) technique. The morphology, size, and shape of the synthesized Nano phosphorous powder were investigated using photoluminescence (PL), scanning electron microscopy (SEM), X-ray diffraction (XRD) and CIE colour coordinates (1931-Chart) analysis. XRD profiles of samples sintered over 1200◦C, suggested phase shift from amorphous powder grain to more ordered polycrystalline powder of triclinic type CaSiO3 phosphor, with preferred crystal phase orientation of (112) and tetragonal type cristobalites of SiO2. The grain size, crystallinity, and chemical composition of the host matrix, activator and sensitizer strongly affected both the absorption and emission bands of these samples. The amplitude of both the orange and red emission bands significantly increased with sintering temperature. The emission band is red-shifted with decreasing grain sizes.
Evaluation of Cancer Stem Cells in Patient-derived Xenografts of Retinoblastoma in a Chick Embryo-Chorioallontoic Membrane Model
Authors: VL Narayana Revu , Mishra Dilip K , Jakati Saumya , Kaliki Swathi , Vemuganti Geeta K 
Published: March 2024

Abstract
Background: Cancer stem cells (CSCs) in most tumors, including retinoblastoma (Rb), are associated with tumor initiation, metastasis, and drug resistance. Our previous studies identified Rb CSCs as CD44+/CD133- by flowcytometry using size and phenotype. In this study, we further evaluated two prime characteristics of CSCs, i.e., chemoresistance and tumor-initiating properties using Chick embryo-Chorioallantoic Membrane (CE-CAM) model.
Methods: After IRB approval was obtained, fresh Rb tumors (n=15) were collected and sorted using antibodies against CD44, followed by CD133. Drug resistance and gene expression were evaluated using the MTT assay and qPCR. Tumor-initiation and metastatic ability were assessed using the CE-CAM assay by transplanting one million cells into a day-7 chick embryo and were evaluated by gross, confocal microscopy, IVIS spectral imaging, alu-qPCR, and histology.
Results: The percentage of CSCs in Rb tumors ranged from 4.8 to 28.4%, exhibiting greater drug resistance and enhanced expression of genes related to CSCs, stemness, drug resistance, EMT and invasion, and metastasis-specific genes than tumor non-CSCs (P<0.0001). The CSCs transplanted cells formed white-colored glistening tumor nodules on the CAM and significantly higher localization of fluorescence signals than non-CSCs (p<0.0001). IVIS imaging revealed positive signals in the brain, which confirmed malignant round cells on histopathology and were quantitatively measured by alu-qPCR.
Conclusion: Rb CSCs (CD44+/CD133-) are endowed with inherent drug resistance and tumor initiation potential, as demonstrated by their enhanced capacity to form tumor xenografts in the CE-CAM model with evidence of metastasis. The CE-CAM is a valuable, cost-effective pre-clinical model that evaluates the pathogenesis of tumor progression and targets therapies.