bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Conversation with Tony Rucci Preparing Future Leaders
Authors: Thompson Kenneth R. 
Published: August 2007

Dr. Anthony J. Rucci became dean of the College of Business Administration at the University of Illinois at Chicago (UIC) in 1998. He returned to academia following a twenty-five year career as a business executive and senior corporate officer with two Chicago-based Fortune 100 companies— Baxter International and Sears, Roebuck & Company. While with Baxter, the health care products company, Tony held a number of positions, including six years as senior vice president for human resources and ended his career as a senior vice president for corporate strategy, business development, and media and investor relations. Between 1993 and 1998, Tony was executive vice president for administration for Sears, which included responsibility for legal, human resources, ethics, administrative services, strategic sourcing, quality and product testing labs, facilities management, and aviation. In addition, from 1995-1997, he was the chairman of the board of directors for Sears de Mexico, Sears' $450 million publicly traded retail business in Mexico. He also served on the boards of Sears Canada, Western Auto, and Grupo Carso's retail board. In 1995, Tony was elected as a Fellow in the National Academy of Human Resources, in 1996 was named to Human Resource Executive Magazine's Executive of the Year Honor Roll, and in 1997 he was named Executive of the Year by the International Association of College and Professional Recruiters. In 1998 he received Workforce magazine's Optimas Award for General Excellence in Human Resources, awarded to Sears for his efforts in the turnaround there. I was excited to do this interview with Tony Rucci as here is a person who has had experience in industry who was now in an academic role and he might have some insights to share about the differences in managing in the different environments.
Business Leaders: A Historical Sketch of Eli Whitney
Authors: Wren Daniel A. , Greenwood Ronald G. 
Published: August 2007

Eli Whitney's America was a nation just recently emerging from its colonial status, and "Yankee ingenuity" would prove essential for it to move from an agrarian society to an industrial one. Whitney was still in college when America's first census, in 1790, showed a total population of 3,231, 533, with over 90 percent of these people engaged in agriculture. The largest city was New York, with a population of 33,131; next came Philadelphia, with 28,522 persons, and then Boston, with a population of 18,300. Together, the three largest U.S. cities had a population that could comfortably be seated in a modern football stadium. Born December 8, 1765, in Westborough, Massachusetts, Eli Whitney Jr. was the eldest of Eli and Elizabeth Whitney's four children. Eli's father had a small workshop on their farm, containing basic tools and a lathe for turning chair legs and the younger Whitney learned how to use these tools. He made and repaired violins and demonstrated his entrepreneurial tendencies early. During the Revolutionary War, he discovered that nails brought a high price and talked his father into letting him use the workshop to make nails for resale. After the war, when nails were no longer in such great demand, he noticed that women had started using long pins to keep their hats on their heads and changed his product line to make hat pins. He aspired to a higher education, but limited family finances delayed his entry into Yale College until 1789, when he was twenty-four years old. His father pledged $1,000 for the four years at Yale, but Eli had to make up the balance of some $600 by tutoring others. At the time, Yale's curriculum provided a classical education, designed to create gentlemen for politics, the ministry, or law, but Eli was not drawn to any of these fields. Unemployed upon graduation in 1792, he was able to gain a tutor's position in the South and traveled to Savannah, Georgia, with another Yale alumnus, Phineas Miller.
Long-Range Activation of GREB1 by Estrogen Receptor via Three Distal Consensus Estrogen-Responsive Elements in Breast Cancer Cells
Authors: Sun Jun , Nawaz Zafar , Slingerland Joyce M. 
Published: August 2007

Abstract
The estrogen receptor (ER) binds to estrogen-responsive elements (EREs) to activate gene transcription. The best characterized EREs are located in proximal gene promoters, but recent data indicate that only a minority of ER binding sites lie within proximal promoter regions. GREB1 (gene regulated by estrogen in breast cancer 1) is an ER target gene that regulates estrogen-induced proliferation in breast cancer cells. We identified three consensus EREs, located at −21.2, −9.5, and −1.6 kb upstream of the closest GREB1a transcription start site that appear to mediate long-range GREB1 gene activation by ER. All three ERE sites nucleate ER, steroid receptor coactivator-3 (SRC-3), and RNA polymerase II (Pol II) and undergo histone acetylation in response to estradiol. Estrogen-stimulated ER binding at all three EREs was cyclic and synchronous. SRC-3 and Pol II recruitment to all three EREs was activated by estrogen but not tamoxifen. In contrast, estrogen stimulated only Pol II and not ER or SRC-3 recruitment to the GREB1 core promoter regions. Long-range histone acetylation, centered on the three ERE motifs and the GREB1 core promoters, was observed in response to estrogen but not to tamoxifen. These data suggest that estrogen-stimulated GREB1 transcription may involve coordinated ER binding to all three distal consensus ERE motifs. Long-range activation by ER acting at multiple EREs may be more common than previously appreciated.
Ultrasound-Guided, Vacuum-Assisted Excision in the Diagnosis and Treatment of Clinically Benign Breast Lesions
Authors: Mathew J , Crawford DJ , Lwin M , Barwick C , Gash A 
Published: August 2007

INTRODUCTION Ultrasound-guided, vacuum-assisted biopsy has a definitive role in the diagnosis of breast lesions. Its role in the treatment of benign breast lesions like fibroadenomas has not been established. PATIENTS AND METHODS This is a retrospective review of patients undergoing ultrasound-guided, vacuum-assisted biopsy for clinically benign breast lesions. The procedures were performed in all cases by two consultant radiologists with special interest in breast radiology between February 2002 and January 2004. Patients were followed up in the clinic 6 weeks after the procedure. RESULTS Seventy-six patients had ultrasound-guided, vacuum-assisted excision of clinically benign breast lesions during this 2-year period. Mean age of the patients was 31 years. Altogether, 86 procedures were performed. Six patients with larger lesions (> 2 cm) had two procedures on separate sitting and 4 patients had separate lesions excised on a later date. Fifty-six patients were identified to have fibroadenomas and had complete excisions as evidenced on scan. Three out of nine patients identified with equivocal disease on fine needle aspiration cytology (FNAC) were found to have cancer following ultrasound-guided, vacuum-assisted excision. One patient who was diagnosed with cancer on FNAC, proved to be fibroadenoma on final histopathology. Four patients developed haematomas following ultrasound-guided, vacuum-assisted excision and all were managed conservatively. CONCLUSIONS Our study shows that ultrasound-guided, vacuum-assisted excision can play an efficient role in the diagnosis of benign breast lesions and is a safe and successful alternative in treatment of fibroadenomas.
Ponseti Treatment in the Management of Clubfoot Deformity – A Continuing Role for Paediatric Orthopaedic Services in Secondary Care Centres
Authors: Docker Charles EJ , Lewthwaite Simon , Kiely Nigel T 
Published: August 2007

INTRODUCTION The Ponseti technique is a well-proven way of managing paediatric clubfoot deformity. We describe a management set-up which spreads the care between secondary and tertiary care with no loss of quality. PATIENTS AND METHODS In our audit of the first 2 years of Ponseti casting in the treatment of idiopathic congenital talipes equinovarus (CTEV, clubfoot) deformity, we identified 77 feet having been treated in 50 patients. Forty-nine feet were treated primarily in Oswestry, a tertiary referral centre for paediatric orthopaedic conditions, and 13 feet were treated in conjunction with the physiotherapy department at one of the region's district general hospitals (Leighton Hospital, Crewe, Cheshire). RESULTS Similar good results and low requirement for surgical interventions other than Achilles tenotomy, which forms part of the Ponseti regimen, were found in both cohorts. CONCLUSIONS This ‘hub-and-spoke’ approach would appear to be efficient in terms of resource utilisation. Additional benefits atients and their carers include ease of access to services and reduced financial and transport burdens.
Dyslipidemia: Reduction in Estimated Risk for Coronary Artery Disease After Use of Ezetimibe with a Statin
Authors: Sampalis John S , Bissonnette Stéphane , Habib Rafik , Boukas Stella 
Published: August 2007

Background: The aim of lipid-lowering treatment is to reduce the risk for cardiovascular events. Patients not at target lipid levels while on hydroxymethylglutaryl coenzyme A reductase inhibitors (statin) monotherapy are at increased cardiovascular risk. Objective: To describe the impact of coadministration of ezetimibe with a statin on the estimated 10 year risk for coronary artery disease (E-RCAD) in patients with hypercholesterolemia and above-target low-density lipoprotein cholesterol (LDL-C) levels after statin monotherapy. Methods: Post hoc analysis was conducted of a prospective, open-label, single-cohort, multicenter Canadian study of 953 patients who were treated for 6 weeks with ezetimibe 10 mg/day coadministered with their current statin at an unaltered dose. For each patient, E-RCAD at baseline and at 6 weeks was calculated using the Framingham model. The primary outcome measure of the analysis was the change in E-RCAD. Results: A total of 825 patients with data at baseline and 6 weeks were included in the analysis. There were 423 (51.3%) patients with hypertension, 107 (13.0%) with diabetes mellitus but not metabolic syndrome, 160 (19.4%) with metabolic syndrome but not diabetes mellitus, and 235 (28.5%) with both diabetes mellitus and metabolic syndrome. After 6 weeks of ezetimibe coadministration with statin therapy, mean E-RCAD was reduced by 4.1% from 15.6% to 11.5%, which is equivalent to a 25.3% risk reduction (p < 0.001). Of the 225 (27.3%) patients with high E-RCAD (≥20.1%) at baseline, 144 (64.0%) converted to a lower E-RCAD category (p < 0.001). Patients with both diabetes mellitus and metabolic syndrome experienced the highest mean percent reduction in E-RCAD of –29.4% (p < 0.001). Conclusions: For patients with above-target LDL-C levels while on statin monotherapy, coadministration of ezetimibe with the statin is effective in significantly reducing the E-RCAD.
Diagnosis and Treatment of Extended-Spectrum and AmpC β-Lactamase–Producing Organisms
Authors: Yang Katherine , Guglielmo B Joseph 
Published: August 2007

Objective: To review the laboratory diagnosis of extended-spectrum β-lactamase (ESBL) and AmpC β-lactamase–producing bacteria and evaluate potential treatment options. Data Sources: A PubMed search, restricted to English-language articles, was conducted (1966–May 2007) using the search terms ESBL, AmpC, diagnosis, detection, carbapenem, ertapenem, fluoroquinolone, cephalosporin, cefepime, tigecycline, and colistin. Additional references were identified through review of bibliographies of identified articles. Study Selection and Data Extraction: All studies that evaluated laboratory methods for the detection of ESBLs and AmpC β-lactamases and/or the treatment of these organisms were reviewed. All articles that were deemed to be clinically pertinent were included and critically evaluated. Data Synthesis: Numerous laboratory techniques are available for the detection of ESBLs. In contrast, laboratory techniques for detection of AmpC β-lactamases are limited, particularly for plasmid-mediated AmpC β-lactamases. Routine microbiologic testing may not detect ESBLs or AmpC β-lactamases. Optimal antibiotic treatment options are derived from limited observational studies and case reports. Randomized clinical trials evaluating appropriate antibiotic treatment options are lacking. In vitro susceptibility does not always correlate with clinical outcomes. The use of imipenem was associated with the lowest incidence of mortality in patients with bacteremia due to ESBL-producing organisms. Conclusions: Laboratory detection of ESBLs for most organisms is possible with Clinical and Laboratory Standards Institute–recommended testing. However, these tests can be associated with both false negative and false positive results, particularly with organisms that harbor both ESBL- and plasmid-mediated AmpC β-lactamases. No established guidelines exist for the detection of AmpC β-lactamases. Imipenem and meropenem are superior to other antibiotics for the treatment of serious infections due to ESBL and AmpC β-lactamase–producing gram-negative bacteria. While in vitro data demonstrate that tigecycline, ertapenem, and colistin might be potential choices, clinical experience is lacking.
Amlodipine-Induced Bilateral Upper Extremity Edema
Authors: Ganeshalingham Anusha , Wong William 
Published: August 2007

Objective: To report a case of bilateral upper extremity edema associated with amlodipine use in a child. Case Summary: A previously well and normotensive 6-year-old girl presented with a generalized vasculitis of unknown origin and severe hypertension. Large vessels predominantly affecting the neck, chest, and abdomen were found to be involved, resulting in abnormal arterial circulation and significant blood pressure differences between the upper and lower extremities. Multiple antihypertensive agents were initially required to control blood pressure. She was stabilized and discharged on amlodipine 10 mg each evening, atenolol 50 mg/day, and warfarin. Three days later she was noted to have facial and bilateral upper extremity pitting edema. Laboratory and radiologic assessments for possible etiologies were negative. Discontinuation of amlodipine resulted in resolution of edema. Discussion: As of June 2007, there had been no cases of bilateral upper extremity edema associated with amlodipine use reported in the English literature. Adverse effects of amlodipine, a widely used antihypertensive, have been well reported. These include flushing, headache, and peripheral edema. Lower limb edema is the most common, while periocular and perioral edema have occurred less frequently. Anasarca edema has been described only once in the English literature. According to the Naranjo probability scale, amlodipine was a probable cause of bilateral upper extremity edema in this child. Conclusions: Bilateral upper extremity edema has been associated with amlodipine use in a child with an abnormal arterial circulation. The edema resolved upon discontinuation of the drug.
Metabolic Syndrome in Childhood Predicts Adult Cardiovascular Disease 25 Years Later: The Princeton Lipid Research Clinics Follow-up Study
Authors: Morrison John A. , Friedman Lisa Aronson , Gray-McGuire Courtney 
Published: August 2007

OBJECTIVE. The goal was to assess the association of metabolic syndrome in childhood with adult cardiovascular disease 25 years later.METHODS. Data from the National Heart, Lung, and Blood Institute Lipid Research Clinics Princeton Prevalence Study (1973–1976) and the Princeton Follow-up Study (2000–2004) were used. BMI was used as the obesity measure in childhood, because waist circumference was not measured in the Lipid Research Clinics study. The adult cardiovascular disease status of participants and their parents was obtained through participant report. A logistic analysis was used to predict adult cardiovascular disease; pediatric metabolic syndrome, age at the Princeton Follow-up Study, gender, race, and parental history of cardiovascular disease were potential explanatory variables.RESULTS. Ages ranged from 6 to 19 years in the Lipid Research Clinics study and from 30 to 48 years in the Princeton Follow-up Study. There were 17 cases of cardiovascular disease in the analysis cohort in the Princeton Follow-up Study. Pediatric metabolic syndrome and age at follow-up assessment were significant predictors of cardiovascular disease. Pediatric metabolic syndrome and changes in age-specific BMI percentile from childhood to adulthood were significant predictors of adult metabolic syndrome.CONCLUSIONS. Evaluating children for metabolic syndrome could identify patients at increased risk of adult cardiovascular disease, making targeted interventions possible.
Medical Home for Children With Hearing Loss: Physician Perspectives and Practices
Authors: Dorros Carol , Kurtzer-White Ellen , Ahlgren Marianne , Simon Peter , Vohr Betty 
Published: August 2007

OBJECTIVE. Our goal was to evaluate Rhode Island pediatricians' view of themselves as the medical home for infants and young children with permanent hearing loss.
METHODS. An observational study was conducted between September 2001 and March 2002. A survey of knowledge, beliefs, and practices relative to newborn hearing screening was sent to Rhode Island pediatricians practicing primary care for children aged birth to 5 years. The data set consisted of 107 (52%) of the eligible physicians.
RESULTS. Seventy-two percent of the pediatricians reported caring for 1 to &gt;5 patients with permanent hearing loss within the past 5 years. Sixty-three percent of the pediatricians reported that the professional who has primary responsibility for follow-up planning for these children is the primary care physician, and 59% agreed that they were the medical home for their patients with hearing loss. However, only 43% agreed that their practice was well informed of services for their patients, and only 45% felt well informed about paths of follow-up. Sixty-three percent of the pediatricians agreed that they should coordinate care, but only 41% reported that they do coordinate care most of the time or always. The pediatricians' preferred methods for receiving educational information were resource guide (85%), grand rounds (75%), or journal articles (73%).
CONCLUSIONS. By contrasting pediatricians' medical home beliefs with actual reported care-coordination practices, we show that there is a disconnect between beliefs and practice. The survey demonstrated that physician belief ratings were consistently higher than the practice ratings, which suggests that the motivation exists but that additional educational efforts and strategies for enhanced care coordination are needed to develop an effective, seamless medical home for children with permanent hearing loss.
An Event-Related Potential Study of Attention and Recognition Memory in Infants With Iron-Deficiency Anemia
Authors: Burden Matthew J. , Westerlund Alissa J. , Armony-Sivan Rinat , Nelson Charles A. , Jacobson Sandra W. , Lozoff Betsy , Angelilli Mary Lu , Jacobson Joseph L. 
Published: August 2007

OBJECTIVES. The purpose of this work was to determine whether iron-deficiency anemia in infancy represents a risk factor for deficits in attention and memory development using event-related potentials.
METHODS. Artifact-free event-related potential data were obtained at 9 and/or 12 months from 15 infants with iron-deficiency anemia and 19 who were iron sufficient during a test of the infant's ability to discriminate a highly familiar stimulus, the mother's face, from a stranger's face.
RESULTS. A midlatency negative component associated with attention and a late-occurring positive slow wave associated with memory updating were identified at both ages in the iron-deficiency anemia and iron-sufficient groups. Consistent with the age-appropriate pattern of development at 9 months, the iron-sufficient group showed a greater attentional response (negative component) to the mother and a greater updating of memory for the stranger (positive slow wave). This pattern of responses was not evident in the iron-deficiency anemia group until 12 months, suggesting a delay in cognitive development.
CONCLUSIONS. These data suggest that iron-deficiency anemia adversely affects the allocation of neurophysiologic resources to attention and recognition memory during the processing of information about familiar and unfamiliar stimuli. This delay in cognitive development may reflect alterations in efficiency of central nervous system functions that seem related to early iron deficiency.
What Is the Early Adulthood Outcome of Boys Who Bully or Are Bullied in Childhood? The Finnish “From a Boy to a Man” Study
Authors: Sourander Andre , Jensen Peter , Rönning John A. , Niemelä Solja , Helenius Hans , Sillanmäki Lauri , Kumpulainen Kirsti , Piha Jorma , Tamminen Tuula , Moilanen Irma , Almqvist Fredrik 
Published: August 2007

OBJECTIVE. Our goal was to study predictive associations between bullying and victimization at age 8 years and psychiatric disorders in early adulthood.
METHODS. The sample comprised 2540 boys born in 1981. Information about bullying and victimization was gathered in 1989 when the boys were 8 years old from parents, teachers, and children. Information about psychiatric disorders was based on military call-up examination and army registry when the subjects were 18 to 23 years old.
RESULTS. In univariate logistic regression analysis, frequent bullying-only status predicted antisocial personality, substance abuse, and depressive and anxiety disorders; frequent victimization-only status predicted anxiety disorder, whereas frequent bully-victim status predicted antisocial personality and anxiety disorder. When controlled against the effects of parental education level and parent and teacher reports of emotional and behavioral symptoms by using Rutter scales, frequent victimization-only status predicted anxiety disorders, and frequent bullying-only predicted antisocial personality disorder, whereas frequent bully-victimization predicted both anxiety and antisocial personality disorder. Information about frequent bullying and victimization as primary screening for children at risk identified ∼28% of those with a psychiatric disorder 10 to 15 years later.
CONCLUSIONS. Both bullying and victimization during early school years are public health signs that identify boys who are at risk of suffering psychiatric disorders in early adulthood. The school health and educational system has a central role to play in detecting these boys at risk.