bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of a gene expression signature associated with brain metastasis in colorectal cancer
Authors: Michl Marlies , Taverna Francesco , Woischke Christine , Li Pan , Klauschen Frederick , Kirchner Thomas , Heinemann Volker , von Bergwelt-Baildon Michael , Stahler Arndt , Herold Tobias Marcus , Jurinovic Vindi , Engel Jutta , Kumbrink Jörg , Neumann Jens 
Published: April 2024

Abstract
Purpose
Brain metastasis (BM) in colorectal cancer (CRC) is a rare event with poor prognosis. Apart from (K)RAS status and lung and bone metastasis no biomarkers exist to identify patients at risk. This study aimed to identify a gene expression signature associated with colorectal BM.

Methods
Three patient groups were formed: 1. CRC with brain metastasis (BRA), 2. exclusive liver metastasis (HEP) and, 3. non-metastatic disease (M0). RNA was extracted from primary tumors and mRNA expression was measured using a NanoString Panel (770 genes). Expression was confirmed by qPCR in a validation cohort. Statistical analyses including multivariate logistic regression followed by receiver operating characteristic (ROC) analysis were performed.

Results
EMILIN3, MTA1, SV2B, TMPRSS6, ACVR1C, NFAT5 and SMC3 were differentially expressed in BRA and HEP/M0 groups. In the validation cohort, differential NFAT5, ACVR1C and SMC3 expressions were confirmed. BRA patients showed highest NFAT5 levels compared to HEP/M0 groups (global p = 0.02). High ACVR1C expression was observed more frequently in the BRA group (42.9%) than in HEP (0%) and M0 (7.1%) groups (global p = 0.01). High SMC3 expressions were only detectable in the BRA group (global p = 0.003). Only patients with BM showed a combined high expression of NFAT5, ACVR1C or SMC3 as well as of all three genes. ROC analysis revealed a good prediction of brain metastasis by the three genes (area under the curve (AUC)  = 0.78).

Conclusions
The NFAT5, ACVR1C and SMC3 gene expression signature is associated with colorectal BM. Future studies should further investigate the importance of this biomarker signature.
Swedish Boys’ Narratives on Sexual Harassment and their Ways of Doing Masculinity
Authors: Lundin Mattias , Eek-Karlsson Liselotte 
Published: April 2024

AbstractWhen #MeToo was the most intensive, many girls, women and non-binary people’s voices were heard about being exposed. Knowledge on boys’ perspectives is important as they need to be involved to provide change. In research, boys’ and men’s voices are missing unless accounted for in settings associated with violence or harassment. This project contributes knowledge about schoolboys’ positionings with respect to masculine hegemony and sexual harassment. The analysis of pair interviews with 22 participating boys, aged 14–16, suggests three ways in which they relate to the topic. With respect to the discursive patterns labelled equal boy and let-go boy, gender issues are competently expressed and these two patterns convey knowledge about the power that the gender culture exercises. These two discursive patterns also suggest a proficient way of taking the gender order into account to fit in with the peer group. Nevertheless, the third pattern, labelled the dominant boy, suggests settings when a traditional masculinity culture exercises power. We conclude that discussions on situations where different discursive patterns are overt would facilitate a shift towards gender equal discourses with less risk of sexual harassment.
The relationship between postpartum mothers’ dyadic coping and adjustment and psychological well-being
Authors: Başgöl Şükran , Koç Emine , Çankaya Seyhan 
Published: April 2024

AbstractThis study determines the relationship between postpartum mothers’ dyadic coping and adjustment strategies and their psychological well-being. The study design was descriptive and correlational; it was conducted in the pediatric outpatient clinic of a maternity hospital in Northern Türkiye. A total of 327 1–12 month postpartum mothers participated in the study. Data were collected using a personal information form, the Dyadic Coping Inventory (DCI), the Revised Dyadic Adjustment Scale (RDAS), and the Psychological Well-Being Scale. Mothers’ behavior as an individual and as a couple in dyadic coping, their perception of their partner’s behavior, and weak dyadic harmony between partners was significantly associated with risk factors affecting mothers’ psychological well-being (p < 0.05). A weak relationship was found between the dimensions of mothers’ psychological well-being and their perception of their own behavior in dyadic coping; a positive moderate relationship was found between mothers’ perception of their partner’s behavior in dyadic coping and behaviors exhibited as a couple in dyadic coping, and the former had a weak positive relationship with the dimensions of dyadic harmony and its subdimensions (p < 0.05). Self-perceived coping behavior, perception of the partner’s behavior, and joint coping behavior in dyadic coping, and weak dyadic harmony between partners were significant risk factors affecting mothers’ psychological well-being. Awareness of these factors by health professionals and individuals will increase the effectiveness of postpartum care and help couples adapt to the transition in the postpartum period, improve mother-father-infant interaction and strengthen dyadic harmony.
Coping skills and perceived stress as pathways to well-being in adolescents experiencing cyber-victimization
Authors: Peker Adem , Cengiz Serkan , Eroğlu Yüksel 
Published: April 2024

AbstractAdolescents experiencing high levels of cyber-victimization may suffer from reduced well-being. Therefore, it is necessary to reveal factors that can increase the well-being of adolescents who experience cyber-victimization. This study examined the mediating effects of perceived stress and coping skills in the relationship between cyber-victimization and well-being. Participants consisted of 543 high school students (45.7% boys, 54.3% girls; Mage = 15.59). Results indicate that cyber-victimization was related to lower well-being through perceived stress, problem solving, and cognitive avoidance. In addition, behavioral avoidance and help-seeking did not play a mediating role in the impact of cyber-victimization on well-being. Lastly, indirect effects tests supported a pathway from cyber-victimization to well-being through perceived stress, problem-solving, and cognitive avoidance. These results improve our understanding of the underlying mechanism between cyber-victimization and well-being by considering the roles of perceived stress and coping skills.
Lateral attitude change: displacement effects as a reaction to blatant social influence
Authors: Linne Roman , Glaser Tina , Bohner Gerd 
Published: April 2024

AbstractAccording to the lateral attitude change (LAC) model, lateral (i.e., indirect) attitude change may occur in the absence of focal (i.e., direct) attitude change. To examine such displacement effects, we asked 124 participants to assume a teacher’s role and grade two moderately good essays. They graded the first essay once before and once after they learned the (very good vs. very poor) grade the essay had allegedly received by a professor. Given that the professor’s grade represented a blatant, disproportionate influence attempt, we hypothesized focal resistance (i.e., no attitude change toward the first essay) but a displacement effect (i.e., attitude change toward the second essay). Instead of displacement, results indicated generalization (focal and lateral effects). However, among participants who had resisted the influence attempt (n = 65), a displacement pattern was observed. Implications for the LAC model are discussed.
A Qualitative Study of Unveiling School Dropout Complexity in Türkiye
Authors: Ozdemir Nurten Karacan , Kemer Fatma Nur Aras , Arslan Arif , Tuna Burak 
Published: April 2024

AbstractThis study investigates school dropout, particularly the shift to open high schools in Türkiye during the pandemic, through a multi-stakeholder lens. Using grounded theory, data was collected via semi-structured interviews with 12 students, 15 teachers, and 20 school administrators. Results reveal a model linking themes: predictive reasons for transferring to open high school, both pandemic-related and unrelated, positive/negative consequences of the transition, pandemic’s impact on formal education continuity, essential open high school skills, and strategies to reduce such preferences. Findings highlight the sway of exam-focused education on open high school interest, regardless of COVID-19, and emphasize the need for equitable education amidst Türkiye’s pandemic challenges. Theoretical implications may infer the necessity of approaching school dropout as a multilayered dynamic issue within the cultural context. The implications also may convey the significance of policies and systems not only to reduce the rates of school dropout but also critically unpack underlying reasons to make improvements.
The correlation study between TOP2A gene expression in circulating tumor cells and chemotherapeutic drug resistance of patients with breast cancer
Authors: Ye Jin-hui , Yu Jian , Huang Ming-ying , Mo Yue-mei 
Published: April 2024

Abstract
Background
Patients with breast cancer (BC) at advanced stages have poor outcomes because of high rate of recurrence and metastasis. Biomarkers for predicting prognosis remain to be explored. This study aimed to evaluate the relationships between circulating tumor cells (CTCs) and outcomes of BC patients.

Patients and methods
A total of 50 female were enrolled in this study. Their diagnoses were determined by clinical characteristics, image data, and clinical pathology. CTC subtypes and TOP2A gene expression on CTCs were detected by CanPatrol™ technology and triple color in situ RNA hybridization (RNA-ISH), which divided into epithelial CTCs (eCTCs), mesenchymal CTCs (MCTCs), and hybrid CTCs (HCTCs) based on their surface markers. Hormone receptor, including estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) expression, was measured by immunohistochemistry (IHC) method before treatment. The risk factors for predicting recurrence and metastasis were calculated by COX risk regression model. The progression-free survival (PFS) of patients was determined using Kaplan–Meier survival curve.

Results
The patients with a large tumor size (≥ 3 cm) and advanced tumor node metastasis (TNM) stages had high total CTCs (TCTCs) (P < 0.05). These patients also had high TOP2A expression level. COX risk regression analysis indicated that TOP2A expression levels in TCTCs, ER + , HER-2 + , and TNM stages were critical risk factors for recurrence and metastasis of patients (P < 0.05). The PFS of patients with ≥ 5 TCTCs, ≥ 3 HCTCs, and positive TOP2A expression in ≥ 3 TCTCs was significantly longer than that in patient with < 5 TCTCs, < 3 HCTCs, and TOP2A expression in < 3 TCTCs (P < 0.05). In contrast, the PFS of patients with positive hormone receptors (ER + , PR + , HER-2 +) also was dramatically lived longer than that in patients with negative hormone receptor expression.

Conclusions
High TCTC, HCTCs, and positive TOP2A gene expression on CTCs were critical biomarkers for predicting outcomes of BC patients. Positive hormone receptor expression in BC patients has significant favor PFS.
Increasing Health Behaviors and Psychological Measures with an Adapted Version of the ACCELERATION Program
Authors: Schwartz Juliano , Rhodes Ryan E. , Oh Paul , Bredin Shannon S. D. , Perotto Maira B. , González Alejandro Gaytán , Warburton Darren E. R. 
Published: April 2024

Abstract
Background
Recent evidence highlights the importance of interventions tackling physical inactivity and unhealthy eating in lower-income countries. The purpose of this study was to examine the effectiveness of the Canadian ACCELERATION lifestyle program adapted to Brazilians. The main outcomes of the study were changes in the engagement in weekly moderate-to-vigorous physical activity (MVPA) and in the daily consumption of fruits/vegetables.

Methods
The adapted intervention consisted of a 12-week quasi-randomized controlled trial delivered through email. The data from the original Canadian experimental group (CE, n = 194) and the two groups of Portuguese-speaking Brazilians living in Canada in the adapted program – Brazilian experimental (BE, n = 41) and Brazilian control (BC, n = 35) – were assessed at baseline and post-intervention. The data of the 270 participants were analyzed using two-way repeated measures factorial ANCOVA (group x time) for ratio variables and Chi-square and McNemar tests for the categorical variables.

Results
The BE group had a significant increase in MVPA (mean difference, 95% CI: 86.3, 38.1–134.4 min/week) and fruits/vegetables intake (3.2, 1.4–5.1 servings/day) after the intervention (both p < 0.001). The proportion of participants engaging in ≥ 150 min of MVPA increased from 4.9% to 73.2%, while adoption of a healthy diet increased from 4.9% to 53.7% in the BE group (both p < 0.001). The CE group also improved on these variables (p < 0.05) with no difference vs the BE group (p > 0.05), whereas BC did not show changes (p > 0.05).

Conclusion
The Brazilian version of the ACCELERATION program effectively promoted positive health behavior changes in its participants and has the potential to contribute to the fight against risk factors for chronic diseases in Brazilians.
Piezoelectric Stretchable Sensor with a Vertical Wavy Structure Fabricated by Combining Dip Coating and Micro-corrugation Process
Authors: Yamamoto Michitaka , Tomita Naoto , Takamatsu Seiichi , Itoh Toshihiro 
Published: April 2024

AbstractA novel fabrication process for a vertical wavy structured stretchable piezoelectric sensor combining dip coating and micro-corrugation process is proposed. By changing the dip coating withdrawal speed, the thickness of PVDF-TrFE (poly(vinylidene fluoride-trifluoroethylene)) films deposited on metal foils was controlled; the wave shape fabricated by the micro-corrugation process was influenced by the PVDF-TrFE film thickness. By reducing the PVDF-TrFE film thickness to less than 5 μm, the wave shape exhibited a high aspect ratio (wave height divided by wave pitch). From estimations obtained by measuring the change in substrate length before and after the microcorrugation process, the predicted stretchability is expected to be greater than 30%. The fabricated vertical wavy structured piezoelectric sensor with a PVDF-TrFE film thickness of approximately 2 μm showed more than 50% stretchability. The fabricated sensor was used as a finger-bending sensor for a virtual reality system, and the proposed process is a promising method for fabricating stretchable sensors.
Diabetic Foot Ulcer Detection: Combining Deep Learning Models for Improved Localization
Authors: Sarmun Rusab , Chowdhury Muhammad E. H. , Murugappan M. , Aqel Ahmed , Ezzuddin Maymouna , Rahman Syed Mahfuzur , Khandakar Amith , Akter Sanzida , Alfkey Rashad , Hasan Anwarul 
Published: April 2024

AbstractDiabetes mellitus (DM) can cause chronic foot issues and severe infections, including Diabetic Foot Ulcers (DFUs) that heal slowly due to insufficient blood flow. A recurrence of these ulcers can lead to 84% of lower limb amputations and even cause death. High-risk diabetes patients require expensive medications, regular check-ups, and proper personal hygiene to prevent DFUs, which affect 15–25% of diabetics. Accurate diagnosis, appropriate care, and prompt response can prevent amputations and fatalities through early and reliable DFU detection from image analysis. We propose a comprehensive deep learning-based system for detecting DFUs from patients’ feet images by reliably localizing ulcer points. Our method utilizes innovative model ensemble techniques—non-maximum suppression (NMS), Soft-NMS, and weighted bounding box fusion (WBF)—to combine predictions from state-of-the-art object detection models. The performances of diverse cutting-edge model architectures used in this study complement each other, leading to more generalized and improved results when combined in an ensemble. Our WBF-based approach combining YOLOv8m and FRCNN-ResNet101 achieves a mean average precision (mAP) score of 86.4% at the IoU threshold of 0.5 on the DFUC2020 dataset, significantly outperforming the former benchmark by 12.4%. We also perform external validation on the IEEE DataPort Diabetic Foot dataset which has demonstrated robust and reliable model performance on the qualitative analysis. In conclusion, our study effectively developed an innovative diabetic foot ulcer (DFU) detection system using an ensemble model of deep neural networks (DNNs). This AI-driven tool serves as an initial screening aid for medical professionals, augmenting the diagnostic process by enhancing sensitivity to potential DFU cases. While recognizing the presence of false positives, our research contributes to improving patient care through the integration of human medical expertise with AI-based solutions in DFU management.
Dispositional Mindfulness and Neural Activity in Youth: A Systematic Review
Authors: Celen Zeynep , Merglen Arnaud , Saccaro Luigi F. , Piguet Camille 
Published: April 2024

Abstract
Objectives
Dispositional mindfulness has been associated with improved emotional regulation, reduced stress, and increased well-being. Interventions aiming at developing dispositional mindfulness are thus promising non-invasive, early interventions for youth at risk for psychiatric disorders. However, little is known about the neural correlates of dispositional mindfulness in adolescents although this could inform response to preventive interventions in youth. This systematic review identified and synthesized existing literature on the functional MRI correlates of dispositional mindfulness in adolescents, to guide and pave the way for interventional studies.

Method
This systematic review included observational studies investigating resting-state or task-based fMRI correlates of mindfulness traits in participants aged between 6 and 25 years, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Four databases were searched up to October 2023, and narrative synthesis of the extracted results was conducted.

Results
The 7 included studies (out of the 2348 screened) had one task-based and six resting state analyses. We focused on reporting resting state studies, where neural correlates of dispositional mindfulness were found in various brain regions, including the frontal cortex, the insula, the thalamus. It was also related to transitions between brain states. These findings suggest that dispositional mindfulness may be associated to underlying processes such as attention, emotion regulation and mind wandering.

Conclusions
Due to the low number of papers, it is difficult to reach a conclusion. Given the need to further investigate the neural correlates of dispositional mindfulness in adolescents to understand the positive behavioral outcomes that are associated with mindfulness, we suggest caveats and perspectives for future studies.

Preregistration
This systematic review is not preregistered.
Development of a 3D Brain Model to Study Sex-Specific Neuroinflammation After Hemorrhagic Stroke
Authors: Islam Rezwanul , Choudhary Hadi Hasan , Mehta Hritik , Zhang Feng , Jovin Tudor G. , Hanafy Khalid A. 
Published: April 2024

AbstractSubarachnoid hemorrhage (SAH) accounts for 5% of stroke, with women having a decreased inflammatory response compared to men; however, this mechanism has yet to be identified. One hurdle in SAH research is the lack of human brain models. Studies in murine models are helpful, but human models should be used in conjunction for improved translatability. These observations lead us to develop a 3D system to study the sex-specific microglial and neuroglial function in a novel in vitro human SAH model and compare it to our validated in vivo SAH model. Our lab has developed a 3D, membrane-based in vitro cell culture system with human astrocytes, microglia, and neurons from both sexes. The 3D cultures were incubated with male and female cerebrospinal fluid from SAH patients in the Neuro-ICU. Furthermore, microglial morphology, erythrophagocytosis, microglial inflammatory cytokine production, and neuronal apoptosis were studied and compared with our murine SAH models. The human 3D system demonstrated intercellular interactions and proportions of the three cell types similar to the adult human brain. In vitro and in vivo models of SAH showed concordance in male microglia being more inflammatory than females via morphology and flow cytometry. On the contrary, both in vitro and in vivo models revealed that female microglia were more phagocytic and less prone to damaging neurons than males. One possible explanation for the increased phagocytic ability of female microglia was the increased expression of CD206 and MerTK. Our in vitro, human, 3D cell culture SAH model showed similar results to our in vivo murine SAH model with respect to microglial morphology, inflammation, and phagocytosis when comparing the sexes. A human 3D brain model of SAH may be a useful adjunct to murine models to improve translation to SAH patients.
Liquid Crystal Based Label-Free Optical Sensors for Biochemical Application
Authors: Tang Jieyuan , Li Zhibin , Xie Mengyuan , Luo Yunhan , Yu Jianhui , Chen Guojie , Chen Zhe 
Published: April 2024

AbstractBiochemical sensors have important applications in biology, chemistry, and medicine. Nevertheless, many biochemical sensors are hampered by intricate techniques, cumbersome procedures, and the need for labeling. In the past two decades, it has been discovered that liquid crystals can be used to achieve the optical amplification of biological interactions. By modifying recognition molecules, a variety of label-free biochemical sensors can be created. Consequently, biochemical sensors based on the amplification of liquid crystals have become one of the most promising sensors. This paper describes in detail the optical sensing principle of liquid crystals, sensing devices, and optical detection technologies. Meanwhile, the latest research findings are elucidated. Finally, the challenges and future research directions are discussed.
Natural compounds proposed for the management of non-alcoholic fatty liver disease
Authors: Merenda Théodora , Juszczak Florian , Ferier Elisabeth , Duez Pierre , Patris Stéphanie , Declèves Anne-Émilie , Nachtergael Amandine 
Published: April 2024

AbstractAlthough non-alcoholic fatty liver disease (NAFLD) presents as an intricate condition characterized by a growing prevalence, the often-recommended lifestyle interventions mostly lack high-level evidence of efficacy and there are currently no effective drugs proposed for this indication. The present review delves into NAFLD pathology, its diverse underlying physiopathological mechanisms and the available in vitro, in vivo, and clinical evidence regarding the use of natural compounds for its management, through three pivotal targets (oxidative stress, cellular inflammation, and insulin resistance). The promising perspectives that natural compounds offer for NAFLD management underscore the need for additional clinical and lifestyle intervention trials. Encouraging further research will contribute to establishing more robust evidence and practical recommendations tailored to patients with varying NAFLD grades.
Graphical Abstract