bluuebunny/crossref_metadata_2025_split huggingface dataset:
Karakteristik Kimia Dan Total Bakteri Saus Sambal Dari Serbuk Ikan Cakalang (Katsuwonus pelamis) Asap
Authors: Sulistijowati Rieny , Ali Merdiyanti K , Suherman Sutianto Pratama 
Published: April 2024

Penelitian ini bertujuan untuk menganalisis mutu kimia dan mikrobiologi saus sambal dari serbuk Ikan Cakalang (Katsuwonus pelamis) asap. Faktor perlakuan yaitu penggunaan tepung sagu, cabe rawit dan cabe keriting yang berbeda. Penelitian ini dirancang menggunakan Rancangan Acak Lengkap Non Faktorial 3 taraf perlakuan dan 2 kali ulangan. Data dianalisis menggunakan ANOVA dan uji lanjut Duncan. Hasil penelitian menunjukkan bahwa saus sambal dari serbuk ikan cakalang dengan penggunaan tepung sagu, cabe rawit dan cabe keriting yang berbeda berpengaruh terhadap nilai mutu kimia dan organoleptik saus. Saus sambal yang dihasilkan mengandung pH berkisar antara 6,57 sampe 6,88, viskositas 31,25 N.s/m2 - 56,25 N.s/m2, kadar protein 19,67% - 19,81%, kadar lemak 33,85% - 46,36% dan nilai TPC 1,18 x103 cfu/ml -1,625 x103 cfu/ml.
Screening Of Phytochemicals Identified And Antioxidant Activity Of Aegiceras corniculatum Extract That Cultivates From The Mangrove Area Of Tarakan City
Authors: Imra Imra , Akhmadi Mohammad Fadnan , Maulianawati Diana , Nur Fitri Awalia , Afriani Sari 
Published: April 2024

Aegiceras corniculatum is mangrove vegetation that is widely spread in the mangrove area in Karang Rejo, Tarakan City and it has the potential for the development of drugs from natural ingredients from tropical sea coasts. The purpose of this study was to determine the water content, bioactive compounds, and antioxidant activity of A. corniculatum. The methods used were the analysis of water content, analysis of bioactive compounds using the phytochemical method, and analysis of antioxidant activity using the DPPH method. This study showed the percentage of moisture or water content in the leaf and fruit extracts of A. corniculatum were 1.83% and 1.95%, respectively. The bioactive compounds detected in the leaf and fruit extracts came from flavonoids, alkaloids, tannins, phenol hydroquinone, and saponins. The antioxidant analysis showed that the fruit and leaf crude extracts had an antioxidant activity with IC50 values were 129.7 ppm and 365.8 ppm, respectively.
Kandungan Karagenan Dan Kekuatan Gel (Kappaphycus alvarezii) Hasil Budidaya Teknologi Kultur Jaringan Secara Massal Basmingro
Authors: Tuiyo Rully , MoO Zulkifli Arsalam 
Published: April 2024

Rumput laut merupakan salah satu tanaman laut yang tumbuh dan tersebar di seluruh wilayah perairan Gorontalo terutama di perairan Gorontalo Utara. Penurunan produksi rumput laut disebabkan bibit yang digunakan sudah mengalami penurunan kualitas dan kuantitas, maka perlu digunakan teknik kultur jaringan secara massal basmingro dalam budidaya upaya peningkatan produksi rumput laut. Penelitian ini bertujuan untuk mengetahui kandungan karagenan dan kekuatan gel hasil budidaya rumput laut (Kappaphycus alvarezii) dengan menggunakan teknologi kultur jaringan secara massal basmingro. Penelitian ini terdiri atas pengujian karegenan dan kekuatan gel hasil panen rumput laut. Hasil penelitian menunjukkan kandungan karagenan K. alvarezi kultur jaringan yaitu 34%, dan rumput laut non kultur jaringan 31,05%. Kekuatan gel rumput laut kultur jaringan 496,36 g/cm2, dan rumput laut non kultur jaringan 406,59 g/cm2. Hal ini menunjukkan bahwa teknik kultur jaringan secara massal basmingro dapat meningkatkan kualitas dari rumput laut.
Kajian Pengaruh Gelatin Tulang Ikan Tuna (Thunnus sp.) Terhadap Nilai Hedonik Dan Viskositas Sabun Gel Alami
Authors: Yusuf Nikmawatisusanti , Naiu Asri Silvana 
Published: April 2024

Gelatin merupakan derivat protien dari serat kolagen yang ada pada kulit dan tulang rawan hewan salah satunya pada ikan. Tujuan penelitian ini untuk mengkaji pengaruh penggunaan gelatin tipe A dari tulang ikan tuna terhadap nilai hedonik dan viskositas sabun gel alami. Gelatin yang digunakan pada penelitian ini adalah gelatin dari tulang ikan tuna yang diekstrak menggunakan cuka aren. Bahan untuk formula sabun terdiri dari; jeruk purut,ketimun, KOH, minyak kelapa, dan minyak zaitun. Formula yang ditambahkan gelatin dengan konsentrasi berbeda (5%, 7,5% dan 10%). Hasil analisis nilai hedonik berdasarkan uji Kruskal Wallis menunjukkan bahwa penambahan gelatin dengan konsentrasi berbeda tidak memberikan pengaruh nyata pada nilai parameter aroma, kenampakan, kesan saat pemakaian, kesan setelah pemakaian serta jumlah busa yang dihasilkan, akan tetapi memberikan pengaruh nyata pada nilai kekentalan sabun. Hasil uji viskositas berdasarkan analisis ANOVA menunjukkan bahwa penambahan gelatin pada formula sabun memberikan pengaruh nyata pada nilai viskositas sabun yang dihasilkan. Hal ini menunjukkan bahwa penambahan gelatin pada formula sabun cair mampu merubah kekentalan sabun yang awalnya cair menjadi sabun gel dengan tidak merubah parameter yang lain. Berdasarkan hasil analisis menunjukkan bahwa konsentrasi gelatin 5% secara organoleptik dapat meningkatkan nilai penerimaan panelis (hedonik) pada kekentalan sabun dan secara kimia konsentrasi tersebut memiliki nilai viskositas yang tinggi yaitu 426,67 cP.
Analisis Total Plate Count (TPC) Dan pH Pada Ikan Mujair (Oreochromis mossambicus) Dengan Perbedaan Suhu Dan Lama Penyimpanan
Authors: Rachmawati Nandya Fitri , Sulthoniyah Siti Tsaniyatul Miratis , Ulfa Rosiana , Amalia Djingga 
Published: April 2024

This research aims to determine the effect of quantitative differences in temperature and storage time on physical changes, TPC values and pH in fresh tilapia fish (Oreochromis mossambicus). The analytical method used is quantitative descriptive analysis. The results showed that the physical characteristics changed in terms of color, texture and aroma with temperature and storage time. The TPC value results were obtained at a temperature of 0 with a storage period of 0 hours, 24 hours, and 48 hours, namely 9.6 x 104 colonies /mL, 9.5 x 104 colonies /mL and 9.4 x 104 colonies/mL. The results of the TPC value were obtained at a temperature of 5 with a storage duration of 0 hours, 24 hours, and 48 hours, namely 9.8 x 104 colonies/mL, 9.7 x 104 colonies/mL and 9.6 x 104 colonies/mL. The TPC value results were obtained at a temperature of 27 with a storage period of 0 hours, 24 hours, and 48 hours, namely 9.9 x 104 colonies/mL, 14.3 x 104 colonies / ml and 18.8 x 104 colonies/mL. The pH value is obtained at a temperature of 0 with a storage duration of 0 hours, 24 hours, and 48 hours, namely 7.1, 7.2 and 7.3. The pH value is obtained at a temperature of 5 with a storage period of 0 hours, 24 hours, and 48 hours, namely 7.1, 7.7 and 7.8. The pH value is obtained at a temperature of 27 with a storage period of 0 hours, 24 hours, and 48 hours, namely 7.2, 5.7 and 5.6. Based on the results of the research conducted, it can be concluded that the treatment of storage temperature and storage duration can affect physical characteristics, Total Plate Count (TPC) value and pH value in tilapia which shows the quality of freshness of the fish.
Analisis Defect Rajungan (Portunus pelagicus) Kaleng Menggunakan Metode Failure Mode And Effect Analysis (FMEA) Di PT. XYZ
Authors: Hasibuan Nirmala Efri , Basri Basri , Ratrinia Putri Wening , Suryono Muh , Azka Aulia , Saputra Eko Novi , Meutia Meta 
Published: April 2024

PT XYZ is an industry that operates in the fisheries sector with superior products, pasteurized crab meat in cans. Increasing market demand, including demand for canned crab exports, requires companies to produce products quickly and correctly. However, in the production of canned crab, defective products are often found or do not meet quality standards. The aim of this research is to identify defect problems in canned crab products and provide suggestions for improvements to overcome the problem in order to minimize the occurrence of defects that are detrimental to the company. Research data collection methods are through observation, interviews and questionary. The Failure Mode and Effect Analysis (FMEA) method is used to identify and analyze defects that occur. FMEA is used to determine the severity level, occurrence level and detection level, so that a Risk Priority Number (RPN) value can be obtained which can determine the priority of defects that must be prioritized for repair. The identification results at PT XYZ found 7 types of defects. The highest RPN defect value that occurs is a rust defect with an RPN value of 324. The defects that occur in this problem are caused by 4 factors, namely humans, methods, materials and the environment. Proposed improvements to reduce the chance of defects occurring in cans include material inspection, human/operator error evaluation, maintaining process environmental conditions, and optimizing the implementation of standard operating procedures (SOP)
A New Tidal Stream Discovered in Gaia DR3
Authors: Tian Hao , Liu Chao , Luo Changqing , Xue Xiang-Xiang , Yang Yujiao 
Published: April 2024

Abstract
Thanks to the precise astrometric measurements of proper motions by the Gaia mission, a new tidal stellar stream has been discovered in the northern hemisphere. The distribution of star count shows that the stream is approximately 80° long and 1.°70 wide. Observations of 21 member stars, including 14 RR Lyrae stars, indicate that the stream has an eccentric and retrograde orbit with e = 0.58. The low metallicity, high total energy, and large angular momentum suggest that it is associated with the merging event Sequoia. This discovery suggests the possibility of finding more substructures with high eccentricity orbits, even in the inner halo.
COMAP Early Science. VIII. A Joint Stacking Analysis with eBOSS Quasars
Authors: Dunne Delaney A. , Cleary Kieran A. , Breysse Patrick C. , Chung Dongwoo T. , Ihle Håvard T. , Bond J. Richard , Eriksen Hans Kristian , Gundersen Joshua Ott , Keating Laura C. , Kim Junhan , Lunde Jonas Gahr Sturtzel , Murray Norman , Padmanabhan Hamsa , Philip Liju , Stutzer Nils-Ole , Tolgay Doğa , Wehus Ingunn Katherine , Church Sarah E. , Gaier Todd , Harris Andrew I. , Hobbs Richard , Lamb James W. , Lawrence Charles R. , Readhead Anthony C. S. , Woody David P. 
Published: April 2024

Abstract
We present a new upper limit on the cosmic molecular gas density at z = 2.4–3.4 obtained using the first year of observations from the CO Mapping Array Project (COMAP). COMAP data cubes are stacked on the 3D positions of 243 quasars selected from the Extended Baryon Oscillation Spectroscopic Survey (eBOSS) catalog, yielding a 95% upper limit for flux from CO(1–0) line emission of 0.129 Jy km s−1. Depending on the balance of the emission between the quasar host and its environment, this value can be interpreted as an average CO line luminosity

L

CO

′

of eBOSS quasars of ≤1.26 × 1011 K km pc2 s−1, or an average molecular gas density

ρ

H

2

in regions of the Universe containing a quasar of ≤1.52 × 108
M
⊙ cMpc−3. The

L

CO

′

upper limit falls among CO line luminosities obtained from individually targeted quasars in the COMAP redshift range, and the

ρ

H

2

value is comparable to upper limits obtained from other line intensity mapping (LIM) surveys and their joint analyses. Further, we forecast the values obtainable with the COMAP/eBOSS stack after the full 5 yr COMAP Pathfinder survey. We predict that a detection is probable with this method, depending on the CO properties of the quasar sample. Based on the achieved sensitivity, we believe that this technique of stacking LIM data on the positions of traditional galaxy or quasar catalogs is extremely promising, both as a technique for investigating large galaxy catalogs efficiently at high redshift and as a technique for bolstering the sensitivity of LIM experiments, even with a fraction of their total expected survey data.
Double Power-law Formation by Sequential Particle Acceleration
Authors: Guidoni S. E. , DeVore C. R. , Karpen J. T. , Alaoui M. 
Published: April 2024

Abstract
Spectral double power laws are common in solar high-energy phenomena such as flares and interplanetary energetic-electron events. However, the physical mechanism that produces the changes in power-law index within a single spectrum is unclear. We developed a fully analytical method of forming single power-law spectra from sequential acceleration of particles orbiting inside and hopping between simulated large-scale magnetic islands formed by flare reconnection. Here, we extend the analytical method to the formation of double power-law spectra by assuming sequential acceleration in two successive regions with different acceleration and particle-transport rates. The resulting spectral distribution is continuous and smooth, with a flattening at low energies, two power-law regions at mid-energies, and a steep rollover at high energies. The model provides analytical expressions for the spectral indices, all energy breaks, and normalization constants as functions of just three physical parameters of each acceleration region: (1) the energy gain in each accelerator, (2) the percentage of particles transferred between accelerators, and (3) the number of accelerators visited. One of the most salient predictions of our work is that the spectral index at high (low) energies is determined by the parameters of the first “seed” (second) acceleration region. By constructing the spectral distribution through an iterative analytical process, the evolution toward a double power law is easily characterized and explained. Our analytical model provides tools to interpret space- and ground-based observations from RHESSI, FOXSI, NuSTAR, Solar Orbiter/STIX, EOVSA, and future high-energy missions.
A Study of the Merging Dwarf Galaxy VCC322
Authors: Zhang Lan-Yue , Zhao Yinghe , Zhang Hong-Xin 
Published: April 2024

Abstract
Galaxy interactions and mergers can enhance or reduce star formation, but a complete understanding of the involved processes is still lacking. The effect of dwarf galaxy mergers is even less clear than their massive counterpart. We present a study on a dwarf merger remnant in the Virgo cluster, VCC322, which might form a triple system with VCC334 and VCC319. We identify a prominent long and straight tail-like substructure that has a size comparable to its host galaxy VCC322. By comparing the color–color (g − r versus r − H) distribution with simple stellar population models, we infer that the metallicity and stellar age of this tail are Z
⋆ ∼ 0.02 Z
⊙ and t
⋆ ∼ 10 Gyr, respectively. In VCC319, we find a sign of isophotal twisting. This suggests that VCC319 may be subject to tidal interaction. An analysis of the Sloan Digital Sky Survey optical spectra of VCC322 indicates mass- and light-weighted ages of about 109.8 yr and 107.5 yr, respectively, indicating an ongoing star formation activity. However, the star formation in VCC322 seems suppressed when compared to other star-forming dwarfs of comparable stellar masses. Our finding of shock excitation of optical emission lines indicates that interaction-induced shock may contribute to the heating of cold gas and suppression of star formation.
Rotational Study of 5:3 and 7:4 Resonant Objects within the Main Classical Trans-Neptunian Belt
Authors: Thirouin Audrey , Sheppard Scott S. 
Published: April 2024

Abstract
The 5:3 and 7:4 mean motion resonances of Neptune are at 42.3 and 43.7 au, respectively, and overlap with objects in the classical trans-Neptunian belt (Kuiper Belt). We report the complete/partial lightcurves of 13 and 14 trans-Neptunian objects (TNOs) in the 5:3 and 7:4 resonances, respectively. We report a most likely contact binary in the 7:4 resonance, 2013 FR28, with a periodicity of 13.97 ± 0.04 hr and a lightcurve amplitude of 0.94 ± 0.02 mag. With a V-/U-shaped lightcurve, 2013 FR28 has one of the largest well-sampled TNO amplitudes observed with ground-based observations, comparable to the well-determined contact binary 2001 QG298. 2013 FR28 has a mass ratio q ∼ 1 with a density ρ ∼ 1 g cm−3. We find several objects with large amplitudes and classify 2004 SC60, 2006 CJ69, and 2013 BN82 as likely contact binaries and 2001 QF331, 2003 YW179, and 2015 FP345 as likely elongated objects. We observe the 17:9 resonant or classical object 2003 SP317 that we classify as a likely contact binary. A lower estimate of 10%–50% and 20%–55% for the fraction of (nearly) equal-sized contact binaries is calculated in the 5:3 and 7:4 resonances, respectively. Surface colors of 2004 SC60, 2013 BN82, 2014 OL394, and 2015 FP345 have been obtained. Including these colors with ones from the literature reveals that elongated objects and contact binaries share the same ultrared surface color, except Manwë–Thorondor and 2004 SC60. Not only are the colors of the 7:4 and 5:3 TNOs similar to the cold classicals, but we demonstrate that the rotational properties of the 5:3 and 7:4 resonants are similar to those of the cold classicals, inferring a clear link between these subpopulations.
Adaptive NK Cells Rapidly Expand during Acute HIV Infection and Persist Despite Early Initiation of Antiretroviral Therapy
Authors: Hearps Anna C , Zhou Jingling , Agius Paul A , Ha Phuongnhi , Lee Silvia , Price Patricia , Kek Hans , Kroon Eugene , Akapirat Siriwat , Pinyakorn Suteeraporn , Phanuphak Nittaya , Sacdalan Carlo , Hsu Denise , Ananworanich Jintanat , Vasan Sandhya , Schuetz Alexandra , Jaworowski Anthony 
Published: April 2024

Abstract
HIV is associated with NK cell dysfunction and expansion of adaptive-like NK cells that persist despite antiretroviral therapy (ART). We investigated the timing of NK cell perturbations during acute HIV infection and the impact of early ART initiation. PBMCs and plasma were obtained from people with HIV (PWH; all men who have sex with men; median age, 26.0 y) diagnosed during Fiebig stages I, II, III, or IV/V. Participants initiated ART a median of 3 d after diagnosis, and immunophenotyping was performed at diagnosis and longitudinally after ART. Anti-CMV Abs were assessed by ELISA. Samples from matched HIV-uninfected males were also analyzed. Proportions of adaptive NK cells (A-NKs; defined as Fcε-Receptor-1γ–) were expanded at HIV diagnosis at all Fiebig stages (pooled median 66% versus 25% for controls; p &lt; 0.001) and were not altered by early ART initiation. Abs to CMV immediate early protein were elevated in PWH diagnosed in Fiebig stages III and IV/V (p &lt; 0.03 for both). Proportions of A-NKs defined as either Fcε-Receptor-1γ− or NKG2C+/CD57+ were significantly associated with HIV DNA levels at diagnosis (p = 0.046 and 0.029, respectively) and trended toward an association after 48 wk of ART. Proportions of activated HLA-DR+/CD38+ NK cells remained elevated in PWH despite early ART initiation. NK cell activation and A-NK expansion occur very early after HIV transmission, before T cell activation, and are not altered by ART initiation during acute infection. A-NKs may contribute to HIV control and thus be useful for HIV cure.
The Lung Microbiome
Authors: Lipinksi Jay H , Ranjan Piyush , Dickson Robert P , O’Dwyer David N 
Published: April 2024

Abstract
Although the lungs were once considered a sterile environment, advances in sequencing technology have revealed dynamic, low-biomass communities in the respiratory tract, even in health. Key features of these communities—composition, diversity, and burden—are consistently altered in lung disease, associate with host physiology and immunity, and can predict clinical outcomes. Although initial studies of the lung microbiome were descriptive, recent studies have leveraged advances in technology to identify metabolically active microbes and potential associations with their immunomodulatory by-products and lung disease. In this brief review, we discuss novel insights in airway disease and parenchymal lung disease, exploring host–microbiome interactions in disease pathogenesis. We also discuss complex interactions between gut and oropharyngeal microbiota and lung immunobiology. Our advancing knowledge of the lung microbiome will provide disease targets in acute and chronic lung disease and may facilitate the development of new therapeutic strategies.
Evaluation of in vitro and in vivo anticancer activities of potassium koetjapate: a solubility improved formulation of koetjapic acid against human colon cancer
Authors: Jafari Seyedeh Fatemeh , Keshavarzi Maryam , AbdulMajid Amin MalikShah , Al-Suede Fouad Saleih R. , Asif Muhammad , Ahamed Mohamed B. Khadeer , Khan Md Shamsuddin Sultan , Hassan Loiy Ahmed Elsir , Majid Aman Shah Abdul , Naseri Mohsen 
Published: April 2024

Background and purpose:
The previous work on koetjapic acid (KA) isolated from Sandoricum koetjape showed its efficacy towards colorectal cancer however KA has poor water solubility which poses the biggest hindrance to its efficacy. In the present paper, an attempt was made to study the anti-colon cancer efficacy of KA’s potassium salt i.e. potassium koetjapate (KKA) applying in vitro and in vivo methods.

Experimental approach:
KKA was produced by a semi-synthetic method. A human apoptosis proteome profiler array was applied to determine the protein targets responsible for the stimulation of apoptosis. Three doses of KKA were studied in athymic nude mice models to examine the in vivo anti-tumorigenic ability of KKA.

Findings/Results:
The results of this study demonstrated that KKA regulates the activities of various proteins. It downregulates the expression of several antiapoptotic proteins and negative regulators of apoptosis including HSP60, HSP90, Bcl-2, and IGF-1 in HCT 116 cells with consequent upregulation of TRAILR-1 and TRAILR-2, p27, CD40, caspase 3, and caspase 8 proteins. Additionally, KKA showed an in vitro antimetastatic effect against HCT 116 cells. These results are feasibly related to the down-regulation of Notch, Wnt, hypoxia, and MAPK/JNK and MAPK/ERK signalling pathways in HCT 116 cells besides the up-regulation of a transcription factor for cell cycle (pRb-E2F) pathways. In addition, KKA revealed potent inhibition of tumor growth.

Conclusion and implications:
In sum, the findings indicate that KKA can be a promising candidate as a chemotherapeutic agent against colorectal cancer.
Використання штучного інтелекту у вищій освіті: стан і тенденції
Authors: Андрощук Аліна Геннадіївна , Малюга Олександр Сергійович 
Published: April 2024

Статтю присвячено актуальній проблемі використанню штучного інтелекту (ШІ) в освіті, Розглянуто стан та тенденції розвитку ШІ, обгрунтовано важливість вивчення даної проблеми та необхідність подальших досліджень, зважаючи на її вплив на академічну доброчесність, якість та успішність навчання. Нова технологія швидко набуває популярності, широко використовується в навчальному процесі та наукових дослідженнях. Це потребує від освітян нагального переосмислення не лише системи оцінювання та контролю, а й всієї парадигми вищої освіти. Процеси глобалізації, цифрова трансформація економіки та суспільства, бурхливий розвиток технологій ШІ вимагає швидкої адаптації багатьох сфер життя та діяльності, та, насамперед, освітньої. Перед освітянами постає необхідність вкотре переглянути та критично оцінити підходи до навчання, зважити усі переваги та недоліки використання ШІ в освітньому процесі. У статті розглянуто існуючі підходи до використання ШІ та ChatGPT, зокрема, проаналізовано існуючий досвід зарубіжних та українських науковців та практиків, висвітлено основні міркування щодо подальшого розвитку та регулювання ШІ як на міжнародному, так і на національному рівнях. Досліджено існуючу нормативно-правову базу та ту, що активно формується, поточну практику розробки та упровадження програм ШІ в навчанні. Робиться висновок, що сектор вищої освіти повинен адаптувати свої підходи до навчання, викладання та оцінювання таким чином, щоб ШІ використовувався ефективно та належним чином, в межах академічної доброчесності. Для використання генеративного ШІ, вкрай необхідно встановити певні правила, або, як мінімум, запустити та підтримувати активну дискусію з цього питання. Це дозволить формувати в університетській спільноті етичні й громадянські компетенції, які допоможуть зменшити негативні й збільшити позитивні наслідки від використання технологій та інструментів ШІ.