bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reexamining the Evidence-Based Practices Attitude Scale-36 (EBPAS-36) in a U.S. Sample of Trauma-Focused Treatment Providers
Authors: Mersky Joshua P. , Lee ChienTi Plummer , Bacalso Edwin , Liu Xiyao 
Published: March 2024

Abstract
Background
Mental health providers’ attitudes toward evidence-based practice are likely to influence what interventions they learn, implement, and sustain over time. Extending research on the 15-item Evidence-Based Practice Attitude Scale (EBPAS), a 36-item version of the EBPAS was recently developed to assess provider attitudes more comprehensively. Research suggests the EBPAS-36 is a promising tool, though inconsistencies across studies suggest there is a need to reexamine its validity and reliability.
Methods
This study assessed the factorial structure of the EBPAS-36, the intercorrelations and reliabilities of its subscales, and correlates of practice attitudes in a U.S. sample of 445 practitioners who received training in trauma-focused cognitive behavioral therapy.
Results
A confirmatory factor analysis verified that the EBPAS-36 fits a 12-factor model representing each of its subscales. Reinforcing prior results, the subscales of the EBPAS-36 were weakly to moderately correlated, suggesting that the 12 domains are related yet distinct. A hypothesized second-order model with three overarching latent factors was not validated, but an alternative two-factor model fit the data adequately. Most subscales demonstrated good-to-excellent internal consistency, though values for the appeal, divergence, and balance subscales ranged from marginally acceptable to poor. Provider attitudes varied by gender, professional experience, and discipline. Practitioners who more frequently assessed client trauma symptoms reported more positive EBP attitudes, and those who expressed greater concerns that trauma assessments may cause harm reported more negative attitudes.
Conclusions
Taken together with previous findings, the results suggest the EBPAS-36 performs well overall, though some subscales may benefit from refinement. Further validation tests of the EBPAS-36 in diverse samples are warranted.
RETRACTED: Design and synthesis of thiourea-conjugating organic arsenic D-glucose with anticancer activities
Authors: Fu Boqiao , Liu Wenxuan , Wang Yufeng , Li Guorui , Huang Xinyuan , Wang Yingsha , Shi Hongan , Qin Caiqin 
Published: March 2024

Abstract

The authors have requested that this preprint be removed from Research Square.
Effects of atorvastatin and its photoproducts on three trophic levels of the aquatic food web and identification of the major photoproducts
Authors: Poncarová Martina , Šorf Michal , Poštulková Eva , Klementová Šárka , Hájek Jan , Fojtíková Pavla , Kahoun David , Hrouzek Pavel , Medková Denisa , Petráňová Pavla 
Published: March 2024

Abstract

Atorvastatin (ATV) photochemical degradation with radiation relevant to the shortest solar radiation wavelengths reaching the Earth’s surface was studied. Fourteen products of photodegradation (P-ATV) were identified by HPLC-HRMS/MS analysis and for twelve of them, chemical structures were proposed. The suggested structures include decarboxylated, dehydrated ATV, ether-like structures and phenanthrene-like byproducts. Toxicity assays revealed that exposure to ATV had a greater negative effect on the growth of the green algae Desmodesmus subspicatus than exposure to P-ATV (IC20 values 140 µg/l and 475 µg/l, resp.). The opposite trend was observed in assays with Daphnia magna where P-ATV were 12 times more toxic than the parent compound (LC50 values obtained for atorvastatin and the photoproduct mixture after 48 h of exposure were 38.5 mg/l and 3.25 mg/l, resp.). Long-term exposure to environmental concentrations showed that P-ATV significantly lowered the number of juveniles of D. magna, while ATV had no effect in comparison to the control group. Neither ATV nor P-ATV affected the interclutch period or the number of clutches. The same trend of higher toxicity of P-ATV was observed in the 96-h test with Danio rerio embryos, where the determined LC50 value for ATV was 5.56 mg/l, while the calculated LC50 value for P-ATV was only 2.74 mg/l. Both groups of embryos of D. rerio (exposed to ATV and P-ATV) showed malformations such as heart oedema and yolk sac oedema with the more pronounced effect being in exposure to P-ATV).
Assessment and mapping of water erosion by the integration of Gavrilovic's "EPM" model in MENA region, case study of the Admer-Ezem sub-watershed, upper Oum-Rbaa basin, Morocco.
Authors: Limame Abdelhak , Hairchi Khalid El , Hanchane Mohamed , Elkhazzan Bouchta , Ouiaboub Lahcen 
Published: March 2024

Abstract

The main goal of the research is to assess soil erosion while analyzing the spatial distribution of its evolution using the empirical erosion potential model, or EPM. Situated northwest of the upper Oum-Rbaa watershed, the Admer-Ezem watershed is part of the research area. Its climate may be described as semi-arid Mediterranean. The quality of the soil could be better. separating the factors of complexity and interdependence in the analysis of erosion risk was made possible quickly and effectively by the Geographic Information System (GIS)'s integration of thematic maps of the various Gavrilovic Equation (EPM) factors with their databases. It also made it possible to evaluate each factor's influence and determine how much it contributed to soil loss. The priority of the various watershed regions was made possible by the use of Gavrilovic's calculations.
This basin covers a total area of 197.59 km2, and is marked by relatively abundant rainfall (800 mm/year), and under strong anthropogenic pressure. This will have an impact of the overexploitation of natural resources in general and soils in particular. Excessive use of agricultural land has led to its fragility and increased susceptibility to erosion. These natural and anthropogenic conditions have induced an intense erosive dynamic, which can be seen in its various forms, (badlands, landslides, and flows, concentrated active ravins…). The use of the “EPM” model for estimating soil losses approximates the severity of the erosion phenomenon. Soil loss due to water erosion according to the model used is estimated at 53.34 t/ha/year as the highest value. And 597.642 t/ha/year as the lowest value. In addition, the analysis of these results made it possible, using GIS, to determine the factors that control water erosion and which are, in order of importance: rainfall, slope and soil sensitivity and soil protection. rainfall, slope, soil sensitivity, and soil protection, in that order of significance.
Sequential development of diffuse panbronchiolitis and myasthenia gravis after thymectomy for thymic neoplasm: a case report
Authors: Chou Chun-Ying , Hsieh Min-Shu , Kuo Ping-Hung 
Published: March 2024

Abstract
Background
Myasthenia gravis (MG) is the most common paraneoplastic disorder associated with thymic neoplasms. MG can develop after thymectomy, and this condition is referred to post-thymectomy myasthenia gravis (PTMG). Diffuse panbronchiolitis (DPB), is a rare form of bronchiolitis and is largely restricted to East Asia, has been reported in association with thymic neoplasms. To our knowledge, only three cases of combined MG and DPB have been reported.
Case presentation:
A 45-year-old Taiwanese woman presented to our hospital with productive cough, rhinorrhea, anosmia, ear fullness, shortness of breath, and weight loss. The patient had a history of thymoma, and she underwent thymectomy with adjuvant radiotherapy 7 years ago. Physical examination revealed coarse breathing sounds with inspiratory crackles. Chest computed tomography scan revealed progressive diffuse bronchitis and bronchiolitis. DPB was confirmed on video-assisted thoracoscopic surgery lung biopsy, and sputum culture showed the presence of Pseudomonas aeruginosa. The patient’s respiratory symptoms improved after treatment with oral azithromycin, levofloxacin, and the transient use of inhaled amikacin. Three months after DPB diagnosis, she developed ptosis, muscle weakness, and hypercapnia, with an arterial partial pressure of carbon dioxide measuring 78.6 mmHg, requiring the use of noninvasive positive pressure ventilation. MG was diagnosed based on the acetylcholine receptor antibody and repetitive stimulation test results. Muscle weakness responded to pyridostigmine and corticosteroids. However, she was readmitted after several months because of another episode of P. aeruginosa-related respiratory infection. Currently, she is in stable condition with long-term maintenance therapies comprising pyridostigmine, corticosteroid, azithromycin, and inhaled amikacin.
Conclusions
To best of our knowledge, this might be the first case of sequential development of DPB followed by PTMG. The coexistence of DPB and PTMG poses a therapeutic challenge for balancing infection control for DPB and immunosuppressant therapy for MG.
Cellular complexity in murine ileitis: Different fibroblasts propel spatially defined ileal inflammation through TNFR1 signalling
Authors: Kollias George , Iliopoulou Lida , Tzaferis Christos , Prados Alejandro , Roumelioti Fani 
Published: March 2024

Abstract
Crohn's disease represents a persistent inflammatory disorder primarily affecting the terminal ileum. Through the application of single-cell RNA sequencing, we unveil the intricate cellular complexities within murine TNF-dependent ileitis, developing in TnfΔARE mice. Detailed immune cell analysis highlights B cell expansion, T cell effector reprogramming, and macrophage lineage shifts during inflammation. Focusing on stromal cells, we reveal a strong pro-inflammatory character, acquired by all fibroblast subsets, which exhibit complex communication patterns with the infiltrating immune and surrounding stromal cells. Interestingly, we identify that TnfΔARE-induced ileitis is initiated in the lamina propria via TNFR1 pathway activation in villus-associated fibroblasts (Telocytes and Pdgfralow cells). Furthermore, we unveil separate spatial subsets of fibroblasts acting as exclusive responders to TNF, each orchestrating inflammation in different intestinal layers. Additionally, manipulating the Tnfrsf1a gene exclusively in fibroblast subsets suggests that inflammation is initiated by telocytes and Pdgfralow cells, while trophocytes drive its progression. This introduces novel evidence of spatial regulation of inflammation by fibroblast subsets, inciting and advancing disease in different layers of the gut. These findings underscore the pivotal role of fibroblasts in the inception and advancement of ileitis, proposing that targeting different fibroblast populations could impede the disease development and chronicity of inflammation.
Plasma levels of tissue plasminogen activator-inhibitor complex (t-PAIC) in patients with acute myocardial Infarction: An observational study
Authors: Feng Yifan , Su mingyu , Xu Huixian , Zhang Shuzhan , Ma Yanfeng , Chen Hongping 
Published: March 2024

Abstract

Introduction: The activation of the plasmatic coagulation system significantly contributes to acute myocardial infarction (AMI). This study aimed to assess the association between tissue plasminogen activator-inhibitor complex (t-PAIC), thrombin-antithrombin complex (TAT), plasmin-α2 plasmin-inhibitor complex (PIC), and thrombomodulin (TM) with clinical outcomes in patients with AMI.
Methods: Blood samples were taken from 368 patients with acute myocardial infarction in the emergency room to measure t-PAIC, TAT, PIC, and TM levels. The patients were followed up for 6 months.
Results: t-PAIC levels were considerably elevated in AMI patients who died compared to those who survived. Additionally, t-PAIC levels were greater in the major adverse cardiovascular events (MACE) group than in the non-MACE group among surviving patients throughout follow-up. Linear regression analysis indicated that high levels of t-PAIC were linked to mortality following acute myocardial infarction and raised the likelihood of MACE in survivors. ROC curve study revealed that t-PAIC has predictive value for mortality following AMI. Analysis of the ROC curve and Kaplan-Meier survival curve demonstrated that t-PAIC was able to forecast MACE in individuals who had experienced an AMI.
Conclusion: Our data suggest that elevated t-PAIC levels increase the mortality rate of AMI patients and increase the 6-month incidence of MACE in AMI survivors.
Injectable 2D-MoS2-integrated adhesive hydrogel for NIR-triggered photothermal and drug-delivery implant in colorectal cancer therapy
Authors: Long Xiaojun , Wang Jiawei , Wang Huijuan , Hu Kepeng , Lin Weiming , Fang Chao , Cheng Kui , Song Zhangfa 
Published: March 2024

Abstract
Patients with advanced colorectal cancer (CRC) and diffuse peritoneal metastasis are not eligible for surgical intervention, and calling for more efficient and precise treatment strategies to complement the traditional systemic chemotherapy and intraperitoneal chemotherapy. Herein, an injectable two-dimensional molybdenum disulfide (2D-MoS2)-integrated adhesive N-(2-aminoethyl)-4-(4-(hydroxymethyl)-2-methoxy-5-nitro-sophenoxy) butanamide-linked sodium alginate-MoS2-5-fluorouracil (AlgNB/MoS2/5-Fu) hydrogel, which can function as an near-infrared light (NIR)-triggered photothermal and drug-delivery implant for CRC treatment is introduced. Ultraviolet (UV) light-activated aldehyde groups in AlgNB bound to the surface-modified MoS2 nanosheets via a Schiff base reaction. The MoS2 nanosheets maintained superior dispersibility in the hydrogel and exhibited a highly efficient NIR-triggered photothermal effect. More importantly, the aldehyde group in AlgNB also imparted tissue adhesion to the hydrogel, the adhesive hydrogel was used to infiltrate and fix in tumor tissue. Combining applications as a 5-Fu drug delivering implant, the injectable adhesive AlgNB/MoS2/5-Fu hydrogel shows remarkable capability in the inhibition of SW480 cells and colorectal tumour regression by triggering photothermal therapy (PTT) and delivering the 5-Fu drug in both in vitro and in vivo studies. Therefore, this research provides distinct guidance strategies for the synergistic tumor therapy of localized CRC and shows enormous potential for cancer treatment in the clinical setting.
Comparative analysis of spatial transport characteristics of spring cold-front-type sandstorms in the Hexi Corridor
Authors: Zhang Chunyan , Li Yanying , Wu Wen , Ma Xingwei , Nie Xin 
Published: March 2024

Abstract
In this study, we investigate the spatial transport characteristics of cold-front-type sandstorms with different intensities in the Hexi Corridor based on the hourly observation data from 13 ground-based meteorological stations in the Hexi Corridor, the data in the upper and lower layers from the Meteorological Information Comprehensive Analysis And Process System, and the three-dimensional aerosol observation data of the Vertical Feature Mask product obtained from the Cloud-Aerosol Lidar with Orthogonal Polarization of the United States. The results show that the influence range and horizontal transport distance of cold-front-type sandstorms in the Hexi Corridor are determined by the intensity, thickness and width of the upper-level troughs and the intensity of cold fronts. Generally, cold fronts pass through the Hexi Corridor from noon to evening and stay in this region for a long time or move slowly, which is favorable to the horizontal long-distance transport of sandstorms. The intensity of the 200 hPa upper-level jets is directly proportional to both the influence range and transport distance of sandstorms which primarily occur on the left side of the exit area of an upper-level jet. The strengthening of upper-level jets induces the formation of the vertical circulation cell at middle and low levels. The ascending branch of the circulation cell lifts sand-dust particles from the surface to the upper layers, and the descending branch transports upper-level momentum to the near-surface. This circulation situation increases the near-surface wind speed and forms sandstorms. The occurrence time and descending branch of the secondary circulation cell caused by upper-level jets are important indicators for predicting the occurrence time and falling area of sandstorms. Dust aerosols are mainly concentrated at a height of 1–4 km, and the thickness of the rising-motion layer determines the thickness and height of dust aerosols. When the maximum rising speed is − 30 × 10− 5 Pa s− 1 or above, dust aerosols reach a height of more than 5 km. When the height of dust aerosols is 2–12 km, and the 500 hPa and 300 hPa wind speed reaches 28 m s− 1 and 32 m s− 1, respectively, the long-distance transport of sandstorms over thousands of kilometers may occur.
Knowledge-based model generation for aircraft cabin noise prediction from pre-design data
Authors: Hesse Christian , Allebrodt Pia , Teschner Mark , Biedermann Jörn 
Published: March 2024

Abstract

The climate targets set out in the "European Green Deal" call for the consideration and implementation of climate-friendly propulsion concepts and sustainable fuels in future aircraft configurations. This puts the use of very efficient propeller engines into the focus of aircraft design. However, these pose major challenges, especially to cabin acoustics, due to high, tonal sound pressure levels on the fuselage. The design of noise control measures requires the competence to predict the resulting interior noise as early as possible in the design process of the vehicle. This requires a high level of geometric and structural detail regarding the fuselage structure and cabin components. With increasing frequency range, the necessary structural details also increase, which have to be resolved in the simulation models due to the associated decreasing structural wavelength. Especially in the context of aircraft pre-design, there is usually not enough information available for a detailed vibro-acoustic modeling of the fuselage and cabin components, which allows a meaningful prediction of the vibrations and thus the cabin noise. Therefore, the knowledge-based tool FUGA (Fuselage Geometry Assembler) is developed for the targeted enrichment of preliminary design data with knowledge for detailed numerical analyses.
This paper describes the knowledge-based geometry and model generation in FUGA, which can consider the necessary (increasing) level of detail for the vibro-acoustic prediction already in the preliminary design. For this purpose, aircraft data sets in the preliminary design data format CPACS (Common Parametric Aircraft Configuration Schema) form the modeling basis. Originating from the aircraft preliminary design, these initially describe the outer shell of the vehicle and are extended by detailed structural information that defines the geometric boundary conditions for component placement in cabin design. For the cabin components, the open-source geometry kernel OCCT (Open Cascade Technology) is used to provide geometries at the level of detail required for subsequent analyses. The geometry models are then discretized in open source (e.g. Gmsh) or commercial meshers and further used for numerical analysis. Finally, the prediction of cabin noise is demonstrated as a Proof of Concept using the example of a short-haul propeller-driven aircraft and the sensitivity of resulting simulation models to the fuselage skin thickness is investigated.
Rising socioeconomic disparities in childhood overweight and obesity in Belgium
Authors: Drieskens Sabine , Charafeddine Rana , Vandevijvere Stefanie , De Pauw Robby , Demarest Stefaan 
Published: March 2024

Abstract
Background
Childhood overweight, especially obesity, significantly impacts children’s health and poses an increased risk of adult-onset diseases. This study aims to analyse the evolution of childhood overweight and obesity in Belgium from 1997 to 2018 and assess its variation across parental socioeconomic status (SES).
Methods
The Health Interview Survey, a cross-sectional survey representative of the Belgian population, has been conducted since 1997, with the latest survey conducted in 2018. This study focuses on children aged 2-17 years. Body Mass Index (BMI, kg/m²) was derived from self-reported data, supplemented with proxy reports for children under 15 years old. Overweight and obesity were classified using age/sex-specific cut-off points. Highest parental educational level served as the indicator of SES. In addition to reporting the overall prevalence and the 95% confidence interval (95%CI) of childhood overweight and obesity by year, this study examines the absolute difference in prevalence between SES groups (low minus high) and calculates the Odds Ratio (OR, adjusted for age and sex) to evaluate the relative difference.
Results
The overall prevalence of childhood overweight rose from 13.6% (95%CI =11.2%-16.1%) in 1997 to 18.9% (95%CI=16.3%-21.5%) in 2018; while it remained stable for obesity, fluctuating between 5.4% and 6.3% over the same period. This increase was more pronounced among children with low SES compared to those with high SES. Consequently, the absolute difference between children with low and high SES increased over time from 8.0 percentage points (pp) in 1997 to 14.9 pp in 2018 for overweight, and from 3.1 pp to 6.8 pp for obesity. In terms of relative inequalities, overall, children with low SES exhibited significantly higher odds of overweight and of obesity than those with high SES (OR varying between 2 à 3 for overweight and between 2 and 4 for obesity).
Conclusions
The escalating disparities over time highlight SES as a significant risk factor for childhood overweight and obesity. Addressing these inequalities requires interventions such as providing healthy meals and increasing sports opportunities at school. Additionally, it is recommended to regulate fast food outlets near schools and limit unhealthy food marketing, particularly because children with low SES are more exposed to such influences.
Human Adipose-Derived Stem Cells Genetically Programmed to Induce Necroptosis for Cancer Immunotherapy
Authors: Na Kun , Bak Soyeon , Kim Kyoung Sub 
Published: March 2024

Abstract

Herein, we present human adipose-derived stem cells (ADSCs) inserted with the receptor-interacting protein kinase-3 (RIP3) gene (RP@ADSCs), which induces cell necroptosis for tumor immunotherapy. Necroptosis has characteristics of both apoptosis, such as programmed cell death, and necrosis, such as swelling and plasma membrane rupture, during which damage-related molecular patterns are released, triggering an immune response. Therefore, necroptosis has the potential to be used as an effective anticancer immunotherapy. RP@ADSCs were programmed to necroptosis after a particular time after being injected in vivo, and various pro-inflammatory cytokines secreted during the stem cell death process stimulated the immune system, showing local and sustained anticancer effects. It was confirmed that RIP3 protein expression increased in ADSCs after RP transfection. RP@ADSCs continued to induce ADSCs death for seven days, and various pro-inflammatory cytokines were secreted through ADSCs death. The efficacy of RP@ADSCs-mediated immunotherapy was evaluated in mouse models bearing GL-26 (glioblastoma) and K1735 (melanoma), and it was found that RP resulted in an increase in the population of long-term cytotoxic T cells and a decrease in the population of regulatory T cells. This shows that RP@ADSCs have potential and applicability as an excellent anticancer immunotherapy agent in clinical practice.