bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maw money, maw problems: A lucrative fish maw fishery in Papua New Guinea highlights a global conservation issue driven by Chinese cultural demand
Authors: Amepou Yolarnie , Chin Andrew , Foale Simon , Sant Glenn , Smailes Olivia , Grant Michael I. 
Published: March 2024

AbstractFish maw (teleost swim bladder) is a dried seafood product valued highly by Chinese cultures in East Asia, though global supply chains are poorly understood. Here, we describe the rapid development of a fish maw fishery in a low‐income nation to illustrate how globalization can affect sustainability. In Papua New Guinea (PNG), fish maw developed into a fishery valued at ∼$831,000 USD annually between 2014–2018. Its development has been driven by Asian expatriates, who provide market access and fishing gear to local communities. The highest valued local species, scaly croaker Nibea squamosa, has a maximum value of $15,615 USD kg−1 (dried) at first‐point‐of‐sale, potentially the highest first‐point‐of‐sale fish maw product globally. Its value has led to high incidental catch rates of threatened species in an area that is a globally significant conservation stronghold. International trade databases need to recognize fish maw as a high value and globally traded product and consider a specific fish maw commodity code to assist nations in identifying emerging fish maw fisheries. Additionally, the Convention on the International Trade of Endangered Species of Flora and Fauna (CITES) could assist in protecting vulnerable fish maw species and facilitate management practices for incidentally caught threatened species.
Effects of meal type on the bioavailability of vutiglabridin, a novel anti‐obesity agent, in healthy subjects
Authors: Won Heejae , Yoon Deok Yong , Lee Sangmi , Cho Joo‐Youn , Oh Jaeseong , Jang In‐Jin , Yoo Sang‐Ku , Yu Kyung‐Sang 
Published: March 2024

AbstractVutiglabridin, which affects the pharmacokinetics (PKs) of food, is currently under clinical development for the treatment of obesity. This study aimed to evaluate the effects of low‐ and high‐fat meals on PKs of vutiglabridin in healthy male subjects. A randomized, open‐label, single‐dose, three‐period, six‐sequence crossover study was conducted. The subjects received a single oral dose of vutiglabridin 480 mg in a fasted state, 30 min after the intake of a low‐fat meal (total 500–600 kcal, fat content 100–125 kcal) and high‐fat meal (total 800–1000 kcal, fat content 500–600 kcal), with a 21‐day washout period. Geometric mean ratios (GMRs) and 90% confidence intervals (CIs) for maximum plasma concentration (Cmax) and area under the plasma concentration‐time curve to the last measurable timepoint (AUClast) were calculated. After intake of low‐ and high‐fat meals, systemic exposure to vutiglabridin was increased, and the time to reach Cmax (Tmax) was delayed compared to that in the fasted state. The GMRs (90% CIs) of low‐fat meal to fasted state for Cmax and AUClast were 2.14 (1.76–2.60) and 2.15 (1.92–2.42), respectively, and those of high‐fat meal to fasted state were 3.07 (2.53–3.72) and 3.00 (2.67–3.37), respectively. The median Tmax was delayed by 1.5 h in both fed states compared with that in the fasted state. The study drug was well‐tolerated after administration in both the fed and fasted states. Food ingestion substantially increased the extent of oral vutiglabridin absorption in healthy subjects, and this enhancement increased with the fat content of the meal.
Art in circulation: Creating content and context for digital reproduction of artworks
Authors: Dhaenens Laurens , Truyen Frederik 
Published: March 2024

AbstractThe use of digital museum objects has become an essential part of museums' communication and marketing strategies, research and teaching, and curatorial practices. This new visibility, amplified by the COVID‐19 crisis, has not only revealed the possibilities of digital museum objects but has also underscored significant challenges, including the intricate relationship between digital museum objects and physical objects, the impact of digital museum objects on knowledge creation, and the online interaction with art and cultural heritage. Furthermore, it has drawn attention to the digital platforms that host digital museum objects, ranging from museum collection databases to online encyclopedias, cultural heritage platforms, and social media. The present paper explores these issues by examining how digital platforms are changing the way digital reproductions of artworks are used and reimagined, both inside and outside the institutions that house the artworks. To illuminate these dynamics, it looks at specific case studies, including the Getty Challenge, the online circulation of Delacroix's La liberté guidant le peuple, and the collection databases of Belgian museums and of the Mauritshuis. Theoretically, it combines the art historical concept of circulation with the notion of gray and colored memory drawn from digital memory studies. In doing so, it conceives of museum databases and cultural heritage platforms, as spaces of participation and neglect, of memory and oblivion, with a vast potential for producing new perspectives on art and cultural heritage and telling new (art) histories. In conclusion, the paper advocates for “circulation” as a key concept for revitalizing online collections of digital reproductions of artworks.
Efficacy of texture and color enhancement imaging for short‐type single‐balloon enteroscopy‐assisted biliary cannulation in patients with Roux‐en‐Y gastrectomy: Multicenter study (with video)
Authors: Tanisaka Yuki , Takenaka Mamoru , Mizuide Masafumi , Fujita Akashi , Jinushi Ryuhei , Shin Takahiro , Sugimoto Kei , Kamata Ken , Minaga Kosuke , Omoto Shunsuke , Yamazaki Tomohiro , Ryozawa Shomei 
Published: March 2024

ObjectivesTexture and color enhancement imaging (TXI) reportedly improves the identification of the papilla of Vater for selective biliary cannulation compared with white light imaging (WLI). This multicenter study evaluated the efficacy of short‐type single‐balloon enteroscopy (SBE)‐assisted biliary cannulation using a new‐generation image‐enhanced endoscopy processing system equipped with TXI in patients who underwent Roux‐en‐Y gastrectomy.MethodsPatients with Roux‐en‐Y gastrectomy with a native papilla, and underwent short SBE‐assisted biliary cannulation during endoscopic retrograde cholangiopancreatography‐related procedures between January 2019 and April 2023 were retrospectively reviewed. Outcomes of biliary cannulation using TXI and WLI were compared. The primary outcome was time to successful biliary cannulation.ResultsThirty‐three patients underwent biliary cannulation with TXI and 98 underwent WLI. The biliary cannulation success rates and median time to successful biliary cannulation with TXI and WLI were 93.9% (95% confidence interval [CI] 79.8–99.3%) and 83.7% (95% CI 74.8–90.4%), respectively (P = 0.14), and 10 min (interquartile range [IQR] 2.5–23.5) and 18 min (IQR 9.75–24), respectively (P = 0.04). Biliary cannulation with TXI required a shorter cannulation time than that required with WLI. Adverse event rates with TXI and WLI did not differ significantly (P = 0.58). Multivariate linear regression analysis showed that the use of TXI and short length of oral protrusion were associated with a shorter successful biliary cannulation time.ConclusionShort SBE‐assisted biliary cannulation was effective and safe on TXI in patients who underwent Roux‐en‐Y gastrectomy, and achieved shorter successful biliary cannulation time.
Infant vocal productions coincide with body movements
Authors: Borjon Jeremy I. , Abney Drew H. , Yu Chen , Smith Linda B. 
Published: March 2024

AbstractProducing recognizable words is a difficult motor task; a one‐syllable word can require the coordination of over 80 muscles. Thus, it is not surprising that the development of word productions in infancy lags considerably behind receptive language and is a known limiting factor in language development. A large literature has focused on the vocal apparatus, its articulators, and language development. There has been limited study of the relations between non‐speech motor skills and the quality of early speech productions. Here we present evidence that the spontaneous vocalizations of 9‐ to 24‐month‐old infants recruit extraneous, synergistic co‐activations of hand and head movements and that the temporal precision of the co‐activation of vocal and extraneous muscle groups tightens with age and improved recognizability of speech. These results implicate an interaction between the muscle groups that produce speech and other body movements and provide new empirical pathways for understanding the role of motor development in language acquisition.Research Highlights
The spontaneous vocalizations of 9‐ to 24‐month‐old infants recruit extraneous, synergistic co‐activations of hand and head movements.
The temporal precision of these hand and head movements during vocal production tighten with age and improved speech recognition.
These results implicate an interaction between the muscle groups producing speech with other body movements.
These results provide new empirical pathways for understanding the role of motor development in language acquisition.
Retinal vascular density as a potential biomarker of diabetic cerebral small vessel disease
Authors: Huang Yinqiong , Wang Siyun , Cai Chi , Huang Xinwei , Chen Yan , Wu Xiaohong , Zhang Yiping , Zhang Yan , Lin Xiahong 
Published: March 2024

AbstractAimThe retina and brain share similar anatomical and physiological features. Thus, retinal imaging by optical coherence tomography angiography (OCTA) might be a potential tool for the early diagnosis of diabetic cerebral small vessel disease (CSVD). In this study, we aimed to evaluate retinal vascular density (VD) in diabetic CSVD by OCTA imaging and explore the associations between retinal VD and cerebral magnetic resonance imaging (MRI) markers and cognitive function.MethodsIn total, 131 patients were enrolled, including CSVD (n = 43) and non‐CSVD groups (n = 88). The VD and foveal avascular zone of the retinal capillary plexus were measured with OCTA. A brain MRI was performed.ResultsMRI imaging showed that in the diabetic CSVD group, white matter hyperintensities (WMHs), particularly deep WMHs (58.82%), are the most common MRI marker, followed by cerebral microbleeds in the subtentorial and cortical areas (34.78%). The CSVD group showed increases in the prevalence of cognitive dysfunction (p = .034) and depression (p = .033) and decreases in visuospatial/executive ability and delayed recall ability. In the CSVD group, VDs of the macular superficial vascular plexus (32.93 ± 7.15% vs. 36.97 ± 6.59%, p = .002), intermediate capillary plexus (20.87 ± 4.30% vs. 23.08 ± 4.30%, p = .005) and deep capillary plexus (23.54 ± 5.00% vs. 26.05 ± 4.20%, p = .003) were lower than those of the non‐CSVD group. Multiple linear regression analysis showed that VD of the macular superficial vascular plexus was independently associated with cerebral microbleeds. Meanwhile, VD of the macular intermediate capillary plexus was associated with white matter lacunar infarcts after adjustment.ConclusionsDiabetic CSVDs are characterized by MRI markers, including deep WMHs and cerebral microbleeds, and showed impaired cognition with decreased visuospatial/executive ability and delayed recall ability. OCTA imaging revealed a significant decrease in retinal microvascular perfusion in diabetic CSVD, which was related to MRI markers and cognitive function. OCTA might be a valuable potential measurement for the early diagnosis of CSVD.
The extent of regeneration is impacted by the stage of amputation in ladybird beetles: A case study in Cheilomenes sexmaculata
Authors: Alam Hera , Rai Shriza , Verma Praveen C. , Mishra Geetanjali 
Published: March 2024

AbstractRegeneration has been a topic of interest across a range of taxa for centuries, and arthropods are no exception. Trade‐offs associated with regeneration are likely to involve the reallocation of resources away from other metabolic activities such as growth, development or reproduction. This might be reflected in costs to some developmental traits of the organism, despite regeneration being advantageous. These associated costs might also differ with the stage of injury or amputation. Here, we hypothesise that the extent of regeneration and trade‐offs associated with it may be stage‐specific. To test this hypothesis, the right forelimb of four larval stages of the ladybird beetle Cheilomenes sexmaculata (Fabricius) (Coleoptera: Coccinellidae) was amputated. Amputated individuals were reared until adulthood, and all developmental transitions were recorded. Regenerated legs in all the treatments were smaller than the controls, which did not experience the amputation, and the regenerative potency of early larval stages was higher than that of late larval stages. Limb regeneration caused delays in post‐amputation developmental duration in all the treatments, increasing their total developmental period. The length of the unamputated left foreleg as well as the wing and antenna size were also reduced in regenerated beetles, showing some internal trade‐off. However, there were no significant differences observed between regenerated and control adults in their fresh body weight and body size. Thus, limb regeneration depends upon the stage of larval development at which the amputation was performed. Amputation also affects the development of other appendages. The delay in normal beetle development might have been observed because of extra resource requirement, their allocation as well as reprogramming of the expression of some genes during regeneration.
Student flow visualization
Authors: Loder Alexander Karl Ferdinand 
Published: March 2024

AbstractUniversities aim at increasing student retention, with evidence‐based and data‐based governance of universities becoming best practice. In this context, managing large amounts of data in university management is a challenge. Sankey diagram visualizations of student flows per time unit (e.g. semesters) have been used as method for structuring but lacked the ability to go beyond program level. This study aims to advance this method by displaying multiple student lifecycles from school to doctorate, while including user‐based input. Data of 83,264 students enrolled into 140,593 programs between 2012/13 and 2022/23 with 657.615 distinct rows in the raw data were used. A self‐synchronizing web interface was provided, including filter and stratification variables. The diagrams could be mapped to students' lifecycles and extended over all degree levels and fields of study. Limitations were data availability and the lack of indicators for each stage of the student lifecycle. Improvements in the mapping are warranted.
School and family ecosystem: Incentives and barriers to school–family communication
Authors: Guedes Fábio Botelho , Cerqueira Ana , Marques‐Pinto Alexandra , Branco Amélia , Galvão Cecília , Sousa Joana , Goulao Luis F. , Bronze Rosário , Viegas Wanda , Gaspar Tania , Moreno Carmen , de Matos Margarida Gaspar 
Published: March 2024

AbstractThe aim of the study was to explore the factors and barriers related to the incentive and opportunity of school–family communication. This work is part of the HOUSE‐Colégio F3 Project, ULisbon, which included 1,143 first‐year university students from the University of Lisbon, with average age of 19.61 ± 3.96 years. The young people who had better communication with their parents, greater family support and better family relationship were the ones who reported greater incentives for school–family communication. School–family communication and relationship were associated with the incentives for school–family communication and greater parental monitoring. These results align with the literature stating that parents' communication and presence in all areas of young people's lives, including the school context, foster better social and family relationships and academic results. This result should not be read as a call for non‐autonomy. Instead, it highlights that monitoring and supporting family presence promotes that autonomy.
Reframing Research and Assessment Practices: Advancing an Antiracist and Anti‐Ableist Research Agenda
Authors: Johnson Angela , Barker Elizabeth , Cespedes Marcos Viveros 
Published: March 2024

AbstractEducators and researchers strive to build policies and practices on data and evidence, especially on academic achievement scores. When assessment scores are inaccurate for specific student populations or when scores are inappropriately used, even data‐driven decisions will be misinformed. To maximize the impact of the research‐practice‐policy collaborative, every stage of the assessment and research process needs to be critically interrogated. In this paper, we highlight the need to reframe assessment and research for multilingual learners, students with disabilities, and multilingual students with disabilities. We outline a framework that integrates three critical perspectives (QuantCrit, DisCrit, and critical multiculturalism) and discuss how this framework can be applied to assessment creation and research.
Lymphatic expression of the proliferation marker Ki67 is linked to sentinel node positivity, recurrence and mortality in primary cutaneous melanoma
Authors: Tan Samuel X. , Chong Sharene , Rowe Casey , Galbraith Jack , Dight James , Zhou Chenhao , Malt Maryrose , Smithers Bernard Mark , Khosrotehrani Kiarash 
Published: March 2024

AbstractLymphangiogenesis is a precursor to lymphovascular invasion, and may therefore signal a higher risk of metastasis and mortality in primary cutaneous melanoma. This retrospective longitudinal study aimed to evaluate whether emergent lymphangiogenesis, as measured through co‐expression of endothelial proteins with the proliferation marker Ki67, was associated with poorer prognosis in a cohort of patients with single primary cutaneous melanoma. We screened all patients with a single locally invasive primary cutaneous melanoma who received sentinel lymph node biopsy at a tertiary dermatology centre in Brisbane, Australia between 1994 and 2007. Primary melanoma sections were stained via Opal multiplex immunofluorescence, and categorized according to the presence of Ki67 within either CD31+ or D2‐40+ endothelial cells. Multivariate Cox regression modelling was used to evaluate associations between endothelial Ki67 positivity and clinical outcomes, with adjustment for age, sex, Breslow depth, ulceration, and anatomical location. Overall, 264 patients were available for analysis, with a median follow‐up duration of 7.1 years. The presence of D2‐40+/Ki67+ co‐expression was associated with greater melanoma‐specific mortality (adjusted hazard ratio [HR]: 2.03; 95% confidence interval [CI]: 1.33–3.10; p = 0.001) and recurrence (adjusted HR: 1.70; 95% CI: 1.33–3.10; p = 0.001) relative to absence. CD31+/Ki67+ co‐expression was not prognostic in this cohort. Lymphatic proliferation, as measured through D2‐40+/Ki67+ co‐expression, predicted greater melanoma‐specific mortality and recurrence in this cohort of primary cutaneous melanoma.
Temperature and CO2 interactively drive shifts in the compositional and functional structure of peatland protist communities
Authors: Kilner Christopher L. , Carrell Alyssa A. , Wieczynski Daniel J. , Votzke Samantha , DeWitt Katrina , Yammine Andrea , Shaw Jonathan , Pelletier Dale A. , Weston David J. , Gibert Jean P. 
Published: March 2024

AbstractMicrobes affect the global carbon cycle that influences climate change and are in turn influenced by environmental change. Here, we use data from a long‐term whole‐ecosystem warming experiment at a boreal peatland to answer how temperature and CO2 jointly influence communities of abundant, diverse, yet poorly understood, non‐fungi microbial Eukaryotes (protists). These microbes influence ecosystem function directly through photosynthesis and respiration, and indirectly, through predation on decomposers (bacteria and fungi). Using a combination of high‐throughput fluid imaging and 18S amplicon sequencing, we report large climate‐induced, community‐wide shifts in the community functional composition of these microbes (size, shape, and metabolism) that could alter overall function in peatlands. Importantly, we demonstrate a taxonomic convergence but a functional divergence in response to warming and elevated CO2 with most environmental responses being contingent on organismal size: warming effects on functional composition are reversed by elevated CO2 and amplified in larger microbes but not smaller ones. These findings show how the interactive effects of warming and rising CO2 levels could alter the structure and function of peatland microbial food webs—a fragile ecosystem that stores upwards of 25% of all terrestrial carbon and is increasingly threatened by human exploitation.
The effect of virtual reality glasses on dental anxiety during scaling and root planing in patients with periodontitis: A randomized controlled clinical trial
Authors: Ceylan Ezgi , Gurbuz Ezgi 
Published: March 2024

AbstractObjectivesThis study aimed to evaluate the effect of virtual reality distraction (VRD) on dental anxiety during scaling and root planing (SRP) in periodontitis patients.Materials and MethodsThis randomized controlled split‐mouth study included 60 patients who scored 9 or above on the dental anxiety scale (DAS) and required SRP in at least two quadrants with at least five teeth and two sites with a probing depth of ≥4 mm. Randomly chosen quadrants were treated using virtual reality glasses, and other quadrants were treated without glasses at the same visit. During VRD, a video of nature scenes was projected onto the screen in front of the patient's eyes. DAS and a visual analogue scale about patient feelings were applied at the end of the procedure.ResultsWith VRD, the scale value of pain and discomfort level (VASP) was significantly reduced (p = 0.01, d = 0.57). Starting treatment without glasses significantly decreased VASP in both control and test sides (p = 0.00, d = 0.85; p = 0.00, d = 0.80, respectively) and increased the sensation of immersion and realism (p = 0.03, d = 0.45; p = 0.02, d = 0.46, respectively). Intraoperative and postoperative DAS values were significantly lower in patients who started treatment without VRD (p = 0.04, d = 0.34; p = 0.02, d = 0.44, respectively). Of the patients, 63.3% preferred VRD in the subsequent treatment. While patient preference did not correlate with sex, it correlated with age (r = −0.48, p = 0.01).ConclusionsThe VRD and initiating SRP procedure with VRD affected the pain and discomfort level in anxious periodontitis patients. In addition, the anxiety level was also affected by starting the procedure with glasses.