bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stage at diagnosis of colorectal cancer in the Middle East and Northern Africa: A population‐based cancer registry study
Authors: Znaor Ariana , Eser Sultan , Bendahhou Karima , Shelpai Wael , Al Lawati Najla , ELBasmi Amani , Alemayehu Elias Mamo , Tazi Mohammed Adnane , Yakut Cankut , Piñeros Marion 
Published: March 2024

AbstractColorectal cancer (CRC) is the 2nd most common cancer and 3rd most common cause of death in the Middle East and Northern Africa (MENA) region. We aimed to explore CRC stage at diagnosis data from population‐based cancer registries in MENA countries. In 2021, we launched a Global Initiative for Cancer Registry Development (GICR) survey on staging practices and breast and CRC stage distributions in MENA. According to the survey results, population‐based data on TNM stage for CRC were available from six registries in five countries (Kuwait, Morocco, Oman, Türkiye, UAE). The proportion of cases with unknown TNM stage ranged from 14% in Oman to 47% in Casablanca, Morocco. The distribution of CRC cases with known stage showed TNM stage IV proportions of 26–45%, while the proportions of stage I cancers were lowest in Morocco (≤7%), and highest (19%) in Izmir, Türkiye. Summary extent of disease data was available from six additional registries and four additional countries (Algeria, Bahrain, Iraq, Qatar). In summary, the proportions of CRC diagnosed with distant metastases in Oman, Bahrain and UAE were lower than other MENA countries in our study, but higher than in European and the US populations. Harmonising the use of staging systems and focusing stage data collection efforts on major cancers, such as CRC, is needed to monitor and evaluate progress in CRC control in the region.
Social competencies of children with disinhibited social engagement disorder: A systematic review
Authors: Davidson Claire , Islam Shahela , Venturini Enrico , Lowit Anja , Gillberg Christopher , Minnis Helen 
Published: March 2024

AbstractBackgroundChildren with Disinhibited Social Engagement Disorder (DSED) have specific difficulties with indiscriminate sociability, yet little is known about their broader social competencies as DSED tends not to be identified within samples in the wider ‘maltreatment literature.’AimTo systematically review the literature to determine the social competencies of children with DSED.MethodsA comprehensive search following PRISMA guidelines was undertaken using PsycINFO, Medline, Embase, and Cumulative Index to Nursing & Allied Health.ResultsFrom a total of 553 articles, 16 studies were selected and critically evaluated. Children with DSED were consistently reported to have poorer social competencies than non‐maltreated peers and environmental controls. Greater peer problems were consistently found, and they may present with poor self‐esteem/concept related to social acceptance. Findings regarding social interaction/communication skills were mixed.Limitations50% of studies were of moderate quality due to sampling and possible confounding variables.ConclusionChildren with DSED present with social relationship problems, beyond the core symptoms of the disorder, but the relative impact of co‐occurring neurodevelopmental conditions is not yet clear. In addition, pragmatic language and communication skills require further research.
Cover Image
Authors: Guo Qianwan , Cui Bo , Yuan Chao , Guo Li , Li Zhao , Chai Qingqing , Wang Na , Gänzle Michael , Zhao Meng 
Published: March 2024

The cover image is based on the Research Article Fabrication of dry S/O/W microcapsule and its probiotic protection against different stresses by Qianwan Guo et al., https://doi.org/10.1002/jsfa.13175.image
Unlocking the potential of olive residues for functional purposes: update on human intervention trials with health and cosmetic products
Authors: Laveriano‐Santos Emily P , Vallverdú‐Queralt Anna , Bhat Rajeev , Tresserra‐Rimbau Anna , Gutiérrez‐Alcalde Eulàlia , Campins‐Machado Francesc M , Lamuela‐Raventós Rosa M , Pérez Maria 
Published: March 2024

AbstractOlive mill waste (OMW) is a promising source of valuable compounds such as polyphenols, terpenes, sterols, and other bioactive compounds, which are of interest to the pharmaceuticals and cosmeceutical industries. This review examines the potential of OMW extracts for health and beauty applications based on evidence reports from human clinical trials. The results achieved to date indicate health‐enhancing properties, but little is known about the underlying mechanisms of action, dose–response relationships, and long‐term impacts. Therefore, while olive by‐products, extracted using eco‐friendly methods, present opportunities for the development of high‐value health and cosmetic products, further studies are necessary to determine the full range of their effects and establish specific therapeutic strategies. © 2024 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Valgus malalignment causes increased forces on a medial collateral ligament reconstruction under dynamic valgus loading: A biomechanical study
Authors: Peez Christian , Deichsel Adrian , Zderic Ivan , Richards R. Geoff , Gueorguiev Boyko , Kittl Christoph , Raschke Michael J. , Herbst Elmar 
Published: March 2024

AbstractPurposeTo investigate the forces on a medial collateral ligament (MCL) reconstruction (MCLR) relative to the valgus alignment of the knee.MethodsEight fresh‐frozen human cadaveric knees were subjected to dynamic valgus loading at 400 N using a custom‐made kinematics rig. After resection of the superficial medial collateral ligament, a single‐bundle MCLR with a hamstring tendon autograft was performed. A medial opening wedge distal femoral osteotomy was performed and fixed with an external fixator to gradually adjust the alignment in 5° increments from 0° to 10° valgus. For each degree of valgus deformity, the resulting forces acting on the MCLR were measured through a force sensor and captured in 15° increments from 0° to 60° of knee flexion.ResultsIrrespective of the degree of knee flexion, increasing valgus malalignment resulted in significantly increased forces acting on the MCLR compared to neutral alignment (p < 0.05). Dynamic loading at 5° valgus resulted in increased forces on the MCLR at all flexion angles ranging between 16.2 N and 18.5 N (p < 0.05 from 0° to 30°; p < 0.01 from 45° to 60°). A 10° valgus malalignment further increased the forces on the MCLR at all flexion angles ranging between 29.4 N and 40.0 N (p < 0.01 from 0° to 45°, p < 0.05 at 60°).ConclusionValgus malalignment of the knee caused increased forces acting on the reconstructed MCL. In cases of chronic medial instabilities accompanied by a valgus deformity ≥ 5°, a realigning osteotomy should be considered concomitantly to the MCLR to protect the graft and potentially reduce graft failures.Level of EvidenceLevel III.
Anterior knee laxity is greater in athletic females who attain menarche at a younger age
Authors: Shultz Sandra J. , Morrissey Matthew C. , Vauhnik Renata 
Published: March 2024

AbstractPurposeFemales with above‐average anterior knee laxity values are at increased risk of anterior cruciate ligament (ACL) injury. The purpose of this study was to examine the effects of menarche age (MA) and menarche offset on anterior knee laxity in young, physically active women.MethodsAnterior knee laxity (KT‐2000) and menstrual characteristics (per self‐report) were recorded in 686 Slovenian sportswomen from team handball, volleyball and basketball club sports (average years sport participation: 7.3 ± 3.6 years). Females were stratified into four groups based on their self‐reported age at menarche: 9–11, 12, 13 and 14+ years. Anterior knee laxity was compared across MA groups using a univariate analysis of variance (ANOVA) with Bonferroni correction, with and without controlling for factors that could potentially differ between groups and influence anterior knee laxity. Females were then stratified into four groups based on the number of years they were away from their age at onset of menarche. Groups were compared using a univariate ANOVA with Bonferroni correction, with and without controlling for factors that differed between groups and could influence anterior knee laxity.ResultsAnterior knee laxity was greater in females who attained menarche at 12 years of age (6.4 ± 1.5 mm) or younger (6.6 ± 1.6 mm) compared to 14 years of age or older (5.8 ± 1.2 mm) (p < 0.001; partial η2 = 0.032). Anterior knee laxity was 0.7–1.4 mm greater in females who were 5 or more years away from menarche compared to those who were within 2 years of menarche (5.8 ± 1.3 mm; p < 0.001).ConclusionAnterior knee laxity is greater in females who attained menarche at a younger age and in females who are 5 or more years postmenarche. Age of menarche represents a critical pubertal event that is easy for women to recall and may provide important insights into factors that moderate anterior knee laxity, a risk factor for ACL injury in women.Level of EvidenceLevel IV.
Self‐Aligned Photonic Defect Microcavity Lasers with Site‐Controlled Quantum Dots
Authors: Shih Ching‐Wen , Limame Imad , Palekar Chirag C. , Koulas‐Simos Aris , Kaganskiy Arsenty , Klenovský Petr , Reitzenstein Stephan 
Published: March 2024

AbstractSelf‐assembled semiconductor quantum dots face challenges in terms of scalable device integration because of their random growth positions, originating from the Stranski–Krastanov growth mode. Even with existing site‐controlled growth techniques, for example, nanohole or buried stressor concepts, a further lithography and etching step with high spatial alignment requirements is necessary to accurately integrate quantum dots into the nanophotonic devices. Here, the fabrication and characterization of strain‐induced site‐controlled microcavities are reported, where site‐controlled quantum dots are positioned at the antinode of the optical mode field in a self‐aligned manner without the need of any further nano‐processing. It is shown that the cavity properties such as Q‐factor, mode volume, and mode splitting can be tailored by the geometry of the integrated buried stressor, with an opening <4 µm. The experimental results are complemented with theory calculations based on continuum elasticity. Lasing signatures, including super‐linear input‐output response and linewidth narrowing, are observed for a 3.6‐µm self‐aligned cavity with a Q‐factor of 18 000. Furthermore, the quasi‐planar site‐controlled cavities exhibit no detrimental thermal effects. This approach integrates seamlessly with the industrial‐matured manufacturing process and the buried‐stressor technique, paving the way for exceptional scalability and straightforward manufacturing of high‐β microlasers and bright quantum light sources.
Airy‐Like Hyperbolic Shear Polaritons in High Symmetry van der Waals Crystals
Authors: Bai Yihua , Zhang Qing , Zhang Tan , Lv Haoran , Yan Jiadian , Wang Jiandong , Fu Shenhe , Hu Guangwei , Qiu Cheng‐Wei , Yang Yuanjie 
Published: March 2024

AbstractControlling light at the nanoscale by exploiting ultra‐confined polaritons—hybrid light and matter waves—in various van der Waals (vdW) materials empowers unique opportunities for many nanophotonic on‐chip technologies. So far, mainstream approaches have relied on interfacial techniques (e.g., refractive optics, meta‐optics, and moire engineering) to manipulate the polariton wavefront. Here, it is proposed that orbital angular momentum (OAM) of incident light can offer a new degree of freedom to structure vdW polaritons. With vortex excitations, a new class of accelerating polariton waves is observed—Airy‐like hyperbolic phonon polaritons (PhPs) in high‐symmetry orthorhombic vdW crystal α‐MoO3. In analogous to the well‐known Airy beams in free space, such Airy‐like PhPs also exhibit self‐accelerating, nonspreading, and self‐healing characteristics. Interestingly, the helical phase gradient of the vortex beam leads to asymmetry excitation of polaritons, as a result, the Airy‐like PhPs possess asymmetric propagation features even with a symmetric mode, analogous to the asymmetry hyperbolic shear polaritons in low‐symmetry crystals. The finding highlights the potential of OAM to manipulate polaritons in vdW materials, which can be further extended into a variety of applications such as active structured polaritonic devices.
Skin‐Friendly Flexible Ultraviolet Detectors Based on Reversibly Deformable Worm‐Like Polymer Nanoparticles
Authors: Han Jianing , Deng Zichao , Wang Rui , Liu Zhefeng , Sun Yalan , Chen Aihua 
Published: March 2024

AbstractFlexible ultraviolet (UV) light detection technology has important applications in wearable devices, smart sensors, and other fields and attracts much attention in recent years. However, for most semiconductor‐based UV detectors, the elastic modulus between rigid semiconductors and flexible substrates is mismatched, which makes it difficult to fabricate UV detectors that meet the needs of wearable devices. Herein, a fully flexible, large‐scale, skin‐friendly UV photodetector component centered on photo‐responsive worm‐like polymer nanoparticles (NPs) is developed, and the resulting device can quantitatively detect UV illumination. Skin‐friendly poly(vinyl alcohol) (PVA), amphiphilic azobenzene‐containing polymer NPs (AzNPs), and water‐soluble ionic liquids (IL) are formed into (AzNPs‐IL)/PVA fabrics by electrospinning. There are interactions such as hydrogen bonding among PVA, AzNPs, and IL, which make the material system stable. The UV detector made of the fabric realizes UV sensing through the illuminance–mechanical stress–electrical signal conversion mechanism. It is capable of achieving a response time of 9 s, a detection range of 10–150 mW cm−2, and stability for 1000 cycle tests upon 365 nm UV irradiation. Moreover, it has good skin affinity, and the water contact angle of the fabric is only 23.57°, which holds great promise for wearable smart devices.
Designing a New Class of Mechanophoric Polymer Based on Epoxy‐Functionalized Rhodamine Derivative
Authors: Chakraborty Swadhin , Bhattacharya Koushik , Choudhury Soumyadip , Singha Nikhil K. 
Published: March 2024

AbstractMechanophoric polymers are an interesting class of smart polymers which contains a special force‐sensitive molecular motif that can lead to a chemical change within the polymer network in response to mechanical force. This investigation reports the design of a mechanophoric polymer based on epoxy‐functionalized rhodamine via a monomeric approach. In this case, rhodamine (Rh) is modified with glycidyl methacrylate (GMA) through an epoxy–amine reaction to design a vinyl‐functionalized multi‐armed macromonomer (Rh‐GMA), which is reacted with butyl acrylate (BA) to prepare the crosslinked polymeric film. The crosslinked polymeric film demonstrates mechanophoric properties under UV and stretching conditions.
Modeling the Interface Between Phases in Dense Polymer‐Carbon Black Nanoparticle Composites by Dielectric Spectroscopy: Where Are We Now and What are the Opportunities?
Authors: Brosseau Christian 
Published: March 2024

AbstractThe macroscopic properties of polymer nanocomposites (PNC) rely largely on the interphase between the polymer chains and the filler particles. One significant difficulty to solve this issue is to quantitatively model the structure‐property correlations due to the interfacial region in these complex materials. While dielectric spectroscopy (DS) measurements are routinely used to characterize the effective permittivity of filled polymers, fitting standard effective medium models and mixing equations to these data remains notoriously difficult to interpret. This is due to the absence of explicit reference to internal length scales characterizing the interfaces in the PNC. As an illustrative example, a two‐level homogenization framework is proposed which enables the extraction of useful information on the impact of a thin interphase confined on a nanometer length scale based on broadband DS data. This model leads to new ways of tuning the interphase so as to optimize the material's response to electric field, a situation relevant for electromagnetic shielding. This approach provides guidance on how to observe directly and experimentally the actual properties of the interface between the phases (as opposed to model‐based inference). Aside from its secure physical foundation in the theory of effective medium, a significant advantage of this approach is that a genetic algorithm (GA) technique applied to this physics‐based model enables the uniqueness of the fit parameters to be considered, as the GA method is robust in terms of finding globally optimum solutions, therefore placing confidence in non‐universal values of the percolation exponents. Recent work in physics‐informed machine learning indicates that the effective dielectric properties of PNC with many degrees of freedom due to their complex morphology can be described by considering only a few degrees of freedom describing the interface features between the phases in these composites.
A comprehensive quality assurance protocol for electromagnetic tracking in brachytherapy
Authors: Dürrbeck Christopher , Gomez‐Sarmiento Isaac Neri , Androulakis Ioannis , Sauer Birte Christina , Kolkman‐Deurloo Inger‐Karine , Bert Christoph , Beaulieu Luc 
Published: March 2024

AbstractBackgroundElectromagnetic tracking (EMT) systems have proven to be a valuable source of information regarding the location and geometry of applicators in patients undergoing brachytherapy (BT). As an important element of an enhanced and individualized pre‐treatment verification, EMT can play a pivotal role in detecting treatment errors and uncertainties to increase patient safety.PurposeThe purpose of this study is two‐fold: to design, develop and test a dedicated measurement protocol for the use of EMT‐enabled afterloaders in BT and to collect and compare the data acquired from three different radiation oncology centers in different clinical environments.MethodsA novel quality assurance (QA) phantom composed of a scaffold with supports to fix the field generator, different BT applicators, and reference sensors (sensor verification tools) was used to assess the precision (jitter error) and accuracy (relative distance errors and target registration error) of the EMT sensor integrated into an afterloader prototype. Measurements were repeated in different environments where EMT measurements are likely to be performed, namely an electromagnetically clean laboratory, a BT suite, an operating room, and, if available, a CT suite and an MRI suite dedicated to BT.ResultsThe mean positional jitter was consistently under 0.1 mm across all measurement points, with a slight trend of increased jitter at greater distances from the field generator. The mean variability of sensor positioning in the tested tandem and ring gynecological applicator was also below 0.1 mm. The tracking accuracy close to the center of the measurement volume was higher than at its edges. The relative distance error at the center was 0.2‐0.3 mm with maximum values reaching 1.2‐1.8 mm, but up to 5.5 mm for measurement points close to the edges. In general, similar accuracy results were obtained in the clinical environments and in all investigated institutions (median distance error 0.1‐0.4 mm, maximum error 1.0‐2.0 mm), however, errors were found to be larger in the CT suite (median distance error up to 1.0 mm, maximum error up to 3.6 mm).ConclusionThe presented quality assessment protocol for EMT systems in BT has demonstrated that EMT offers a high‐accuracy determination of the applicator/implant geometry even in clinical environments. In addition to that, it has provided valuable insights into the performance of EMT‐enabled afterloaders across different radiation oncology centers.
Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals
Authors: Simkins Joanna , Holden Melanie A. , Babatunde Opeyemi , White Simon , Nicholls Elaine , Long Angela , Dziedzic Krysia , Chudyk Adrian , Todd Adam , Walker Christine , Stanford Colin , Cottrell Elizabeth , Edwards John , Healey Emma L. , Cork Tania , Mallen Christian , O’Brien Nicola 
Published: March 2024

AbstractIntroductionOsteoarthritis is the commonest form of chronic joint pain, which patients often self‐manage before seeking healthcare advice. Patients frequently seek advice from community pharmacies, and a recent policy has recommended integrating community pharmacies into long‐term condition pathways. This study explored community pharmacy teams' (CPs) and other healthcare professionals' (HCPs) views on community pharmacies providing an extended role for osteoarthritis management, identifying potential barriers and facilitators to this.MethodsA multi‐methods study comprising surveys of CPs and other HCPs, followed by qualitative interviews. Descriptive statistics were used in an exploratory analysis of the survey data. Qualitative data were analysed using reflexive thematic analysis and the identified barriers and facilitators were mapped to the Theoretical Domains Framework.ResultCPs and other HCPs in the surveys and interviews reported that an extended role for osteoarthritis management could include: a subjective assessment, explaining the joint problem and its treatment, medication management and support for self‐care. There was less consensus on diagnosing the problem as OA and completing an objective assessment. A key facilitator was training to deliver the role, whilst barriers were high workload and lack of access to General Practitioner medical records.DiscussionAcceptable elements of an extended community pharmacy role for osteoarthritis centre around the provision of information, advice on medication and supported self‐management.ConclusionCPs are well placed to contribute towards evidenced‐based osteoarthritis management. Feasibility testing of delivering the extended role is needed and future implementation requires training for CPs and raising public awareness of the extended role.