bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymorphism rs3733591 of the SLC2A9 gene and metabolic syndrome affect gout risk in Taiwan Biobank subjects
Authors: Lin Chun-Nan , Ho Chien-Chang , Hsieh Pao-Chun , Hsiao Chih-Hsuan , Nfor Oswald Ndi , Liaw Yung-Po 
Published: April 2024

Background:Over the past few decades, gout and diseases like metabolic syndrome (MetS) have become more prevalent. Attempts have been made in Taiwan to identify the genes responsible for gout. A few gene loci, among themSLC2A9, have been identified using Taiwan Biobank (TWB) data. We, therefore, examined whether MetS could also account for the association between polymorphismSLC2A9rs3733591 and gout.Methods:The final analysis consisted of 73,558 subjects, of whom 2,709 had gout. To estimate the likelihood of gout occurrence based on rs3733591 and MetS, we used logistic regression models.Results:Rs3733591-TC + CC compared to TT genotype was associated with gout (OR, 1.15; 95% CI, 1.06–1.25). Also associated with gout was MetS (OR, 1.21; 95% CI, 1.10–1.33). A significant interaction was seen between rs3733591 and MetS (p-value = 0.039). Using rs3733591-TT/no MetS as the reference group, the ORs (95% CI) for gout was 1.24 (1.11–1.38) for TC + CC/no MetS, 1.35 (1.17–1.56) for TT/MetS, and 1.39 (1.22–1.58) for TC + CC/MetS. However, subgroup analysis defined by sex showed no significant associations in women.Conclusion:In summary, metabolic syndrome andSLC2A9rs3733591 genotypes were interactively associated with gout in Taiwanese men, but not women.
Identification and validation of potential diagnostic signature and immune cell infiltration for HIRI based on cuproptosis-related genes through bioinformatics analysis and machine learning
Authors: Xiao Fang , Huang Guozhen , Yuan Guandou , Li Shuangjiang , Wang Yong , Tan Zhi , Liu Zhipeng , Tomlinson Stephen , He Songqing , Ouyang Guoqing , Zeng Yonglian 
Published: April 2024

Background and aimsCuproptosis has emerged as a significant contributor in the progression of various diseases. This study aimed to assess the potential impact of cuproptosis-related genes (CRGs) on the development of hepatic ischemia and reperfusion injury (HIRI).MethodsThe datasets related to HIRI were sourced from the Gene Expression Omnibus database. The comparative analysis of differential gene expression involving CRGs was performed between HIRI and normal liver samples. Correlation analysis, function enrichment analyses, and protein-protein interactions were employed to understand the interactions and roles of these genes. Machine learning techniques were used to identify hub genes. Additionally, differences in immune cell infiltration between HIRI patients and controls were analyzed. Quantitative real-time PCR and western blotting were used to verify the expression of the hub genes.ResultsSeventy-five HIRI and 80 control samples from three databases were included in the bioinformatics analysis. Three hub CRGs (NLRP3, ATP7B and NFE2L2) were identified using three machine learning models. Diagnostic accuracy was assessed using a receiver operating characteristic (ROC) curve for the hub genes, which yielded an area under the ROC curve (AUC) of 0.832. Remarkably, in the validation datasets GSE15480 and GSE228782, the three hub genes had AUC reached 0.904. Additional analyses, including nomograms, decision curves, and calibration curves, supported their predictive power for diagnosis. Enrichment analyses indicated the involvement of these genes in multiple pathways associated with HIRI progression. Comparative assessments using CIBERSORT and gene set enrichment analysis suggested elevated expression of these hub genes in activated dendritic cells, neutrophils, activated CD4 memory T cells, and activated mast cells in HIRI samples versus controls. A ceRNA network underscored a complex regulatory interplay among genes. The genes mRNA and protein levels were also verified in HIRI-affected mouse liver tissues.ConclusionOur findings have provided a comprehensive understanding of the association between cuproptosis and HIRI, establishing a promising diagnostic pattern and identifying latent therapeutic targets for HIRI treatment. Additionally, our study offers novel insights to delve deeper into the underlying mechanisms of HIRI.
Proteomic analysis reveals a potential role for extracellular vesicles within the erythroblastic island niche
Authors: Ventura Telma , Fidanza Antonella , Wilson Marieangela C. , Ferguson Daniel C. J. , Lewis Phillip A. , May Alisha , Taylor Helen , Rimmer Michael P. , Gregory Christopher D. , Frayne Jan , Forrester Lesley M. 
Published: April 2024

Introduction: Erythroblastic island (EBI) macrophages play an essential role in the production and maturation of the vast numbers of red blood cells (RBCs) that are produced throughout life. Their location within the bone marrow makes it difficult to study the cellular and molecular interactions associated with their action so we have used an in vitro model of the EBI niche using macrophages derived from human induced pluripotent stem cells (hiPSCs). We previously demonstrated that the activation of the transcription factor KLF1 enhanced the activity of hiPSC-derived EBI macrophages.Methods: To elucidate the mechanisms associated with EBI-like activity we carried out a quantitative proteomic analysis and assessed the role of extracellular vesicles using Nanosight Tracking analyses and media filtration.Results and Discussion: Gene ontology analysis showed that many of the proteins upregulated by KLF1 were protein-binding factors, some of which were associated with the cell membrane or extracellular vesicles We demonstrated that filtration of macrophage-conditioned media resulted in a reduction in the supportive effects on erythroid cell viability and maturation implying a role for extracellular vesicles but this was not KLF1 dependent. Pathway analyses of the proteomic data revealed that proteins upregulated by KLF1 were associated with the citric acid cycle, pyruvate metabolism and ATP synthesis indicating that KLF1-activated macrophages had a metabolic profile comparable to a pro-reparative phenotype. This study has generated a proteomic dataset that could provide new insights into the role of macrophages within the EBI niche and has indicated a potential role for extracellular vesicles in the differentiation and maturation of RBCs in vitro. Further research will aid in the production of RBCs in vitro for use in disease modelling and cell therapy.
Association between disability and cognitive function in older Chinese people: a moderated mediation of social relationships and depressive symptoms
Authors: Ai Fangzhu , Li Enguang , Dong Aohua , Zhang Huijun 
Published: April 2024

ObjectiveMany previous studies have found that disability leads to cognitive impairment, and in order to better understand the underlying mechanisms between disability and cognitive impairment, the present study aimed to investigate the moderating role of social relationships, including their role as mediators between disability and cognitive impairment in depressive symptoms.Study designThis is a cross-sectional study.MethodsA total of 5,699 Chinese older adults from the 2018 China Longitudinal Healthy Longevity Survey (CLHLS) were included in this study, and PROCESS macro was used to perform simple mediator and moderator mediator analyses, which were used to analyze the relationship between depressive symptoms and social relationships between disability and cognitive impairment.ResultsThe results of this study showed significant correlations between disability, cognitive impairment, depressive symptoms, and social relationships, and that depressive symptoms mediated the relationship between disability and cognitive functioning [B = −0.232; 95% CI: (−0.304, −0.164)], and that social relationships mediated disability and cognitive functioning through pathway a (Disability-Depressive Symptoms) [B = 0.190; 95% CI: (0.020, 0.036)], path b (depressive symptoms-cognitive impairment) [B = 0.029; 95% CI: (0.015, 0.042)], and path c’ (incapacitation-cognitive impairment) [B = 0.492; 95% CI: (0.298, 0.685)] to modulate the effect of incapacitation on cognitive impairment. In addition, social activities and social networks moderated the mediation model directly or indirectly, whereas social support moderated only the direct effect.ConclusionThis study explains the intrinsic link between incapacitation and cognitive impairment in Chinese older adults, and that social relationships and depressive symptoms can directly or indirectly modulate the effects between them. This provides a basis for healthcare professionals to be able to better develop interventions that can be used to improve the level of cognitive functioning and mental health of older adults.
The impact of conventional cigarettes, e-cigarettes, and tobacco heating systems on the oral mucosa
Authors: Miklyaev S. V. , Blokhina N. A. , Chuprikov N. S. 
Published: April 2024

Relevance. Over the past few years, the popularity of nicotine-containing substances and tobacco heating systems has continued to grow, while the demand for conventional tobacco leaf cigarettes has been falling. Electronic cigarettes consist of a heating system and a liquid with various flavorings. During the operation of the heating stick, the liquid is converted into an aerosol, which the user needs to inhale. First of all, the hot steam comes into contact with the oral cavity. The aerosol components settle on the oral mucosa, the approximal surfaces of the teeth, penetrating the body with a saliva current, expose the oral cavity to prolonged exposure, causing various changes in the oral cavity and causing discomfort to the smoker. This problem is urgent and based on the above, it is necessary to study all possible effects of cigarettes and electronic nicotine delivery systems on the human body.Purpose. To assess the impact of nicotine-containing products and smokeless tobacco on the oral mucosa.Materials and methods. A cohort of 98 patients, aged 20 to 60, was recruited for the study. Participants were divided into four groups: Group 1 consisted of conventional cigarette smokers; Group 2, users of vapes; Group 3, users of IQOS; and Group 4 included patients who used all three device types interchangeably.Results. The investigation identified a direct correlation between the participant's age, the device used, and their level of oral hygiene. The poorest oral hygiene was seen in Group 4, where individuals used a combination of conventional cigarettes, vapes, and IQOS. Although a majority acknowledged the harmful effects of tobacco products, only 33 participants were aware of the negative impacts associated with vapes and IQOS.Conclusion. The lack of regulation and awareness of the health risks associated with IQOS and vaping pose substantial challenges for healthcare, indicating a need for more research into these issues.
USP18 Antagonizes Pyroptosis by Facilitating Selective Autophagic Degradation of Gasdermin D
Authors: Wang Liqiu , Li Mengqiu , Lian Guangyu , Yang Shuai , Wu Yaoxing , Cui Jun 
Published: April 2024

As a key executioner of pyroptosis, Gasdermin D (GSDMD) plays a crucial role in host defense and emerges as an essential therapeutic target in the treatment of inflammatory diseases. So far, the understanding of the mechanisms that regulate the protein level of GSDMD to prevent detrimental effects and maintain homeostasis is currently limited. Here, we unveil that ubiquitin-specific peptidase 18 (USP18) works as a negative regulator of pyroptosis by targeting GSDMD for degradation and preventing excessive innate immune responses. Mechanically, USP18 recruits E3 ubiquitin ligase mind bomb homolog 2 (MIB2) to catalyze ubiquitination on GSDMD at lysine (K) 168, which acts as a recognition signal for the selective autophagic degradation of GSDMD. We further confirm the alleviating effect of USP18 on LPS-triggered inflammation in vivo. Collectively, our study demonstrates the role of USP18 in regulating GSDMD-mediated pyroptosis and reveals a previously unknown mechanism by which GSDMD protein level is rigorously controlled by selective autophagy.
InGaN-based blue, green monolithic micro-LED display with n-type interlayer
Authors: Okuno Koji , Goshonoo Koichi , Ohya Masaki 
Published: April 2024

Abstract
InGaN-based monolithic full-color LEDs, such as augmented reality and virtual reality, are candidates for displays with highly integrated pixels. We demonstrated a monolithic micro-LED display with green- and blue-emitting active layers separated by an n-type interlayer. The interlayer plays an important role in individually emitting green and blue light. The monolithic LED display was fabricated by mesa formation reaching the interlayer and the regrowth of the p-type layer, resulting in horizontally integrated green and blue LEDs. The display measuring 0.64 mm2 with 20 rows and 20 columns had 40 μm × 40 μm pixels comprising 20 μm × 40 μm sub-pixels with an emitting area of 8 μm × 23 μm and was driven by a passive matrix circuit. Images of the monolithic micro-LED display were successfully obtained by individually controlling the green- and blue-emitting micro-LEDs. These results will enhance the commercialization of micro-LED displays.
Irrational behavioral models of personal finance and their evolution in the digital economy
Authors: Tserkasevich L. V. 
Published: April 2024

Aim. To review the evolution of scientific concepts investigating the motives for decision[1]making based on irrational consumer behavior and to identify real changes in behavioral models of personal finance. Objectives. To examine the evolution of scientific concepts of the world’s leading scientists on decision-making motives in the consumer market; to consider the effects of irrational consumer behavior; to identify key changes in consumer buying decision behavior caused by digitalization. Methods. The article is based on the analysis of scientific works of leading classical economists, interdisciplinary scientific research of modern foreign and domestic scientists devoted to the issues of decision-making in the field of consumption. The institutional approach was applied, which allowed us to study the evolution of irrational behavior in the field of personal finance depending on the dominant social values. Results. In the process of analyzing theoretical provisions of famous scientists up to the middle of the twentieth century, the justification of consumers’ decision-making in the consumer market based on their desire to maximize pleasure, utility of welfare is presented. Such behavior can be attributed to irrational behavior. Gradually, taking into account the market regulators of consumption opportunities, scientists come to the conclusion about the rational behavior of individuals. However, by the end of the twentieth century, the position of scientists changes towards limited rationality due to the inability of individuals to adequately assess the array of information affecting decision-making in the consumer market. On the basis of conclusions drawn by modern scientists in the framework of interdisciplinary research, such a new direction of economic science as “behavioral economics” emerges, which combined the knowledge of both economics and psychology. Modern research has shown some effects in behavioral finance related to the irrationality of consumer behavior when making a purchase decision: the Veblen effect, the Diderot effect and others. The latest research on the impact of digitalization on consumer behavior reflects the changes taking place in consumer behavior towards rationalization. Conclusions. The concepts and models describing the peculiarities of irrational behavior of individuals related to decision-making and based on irrational spending of personal financial resources from the point of view of classical economic science are considered. The evolution of scientific concepts of irrational behavior of the world’s leading economists during two centuries is presented. The effects of irrational consumer behavior proposed by scientists in the framework of interdisciplinary research are studied. Among them are the Veblen effect, the Diderot effect. The influence of digitalization on personal finance decision-making is shown.
Modern mechanisms of state management of sustainable development
Authors: Fuyuan Xi 
Published: April 2024

Aim. To analyze contemporary mechanisms of public governance of sustainable development (SD) with a focus on the energy transition and climate agenda.Objectives. To focus on strategies and practices adopted in China and Russia, comparing their approaches to achieving SD goals; to examine international experience, analyze investments in renewable energy sources (RES) and decarbonization; to review adopted regulations and management strategies in these areas; to study national and international strategies, legislation and practices aimed at increasing the share of RES and reducing carbon dioxide emissions; to assess the effectiveness of measures taken to manage SD (with special attention to the eMethods. This article is based on the analysis of data from reports of international organizations, statistical data of governmental bodies, as well as on the review of national strategies and legislation. Mechanisms and results of RES management, climate policy and decarbonization in different countries are compared.Results. Despite differences in approaches and strategic priorities, both Russia and China are making significant efforts to accelerate the transition to sustainable energy systems and reduce greenhouse gas emissions. However, China demonstrates a more active and ambitious RE policy and climate initiatives, while Russia is at an early stage of this process.Conclusions. The importance of global and regional cooperation in sharing experiences and technologies to achieve SD goals is emphasized. Both Russia and China demonstrate a growing understanding of the need to regulate SD, but their approaches and strategies differ depending on internal and external factors.
Bureaucratic structure of management of the organization in today’s conditions of uncertainty
Authors: Elkina O. S. , Pavlov A. E. 
Published: April 2024

Aim. To prove the facts of inefficiency of application of bureaucratic type of organizational structure of management, lack of its influence on economic growth in the conditions of growing global economic uncertainty. Objectives. To systematize the negative features of the bureaucratic model of management, reflected in the works of researchers of the XX century (among them - E. Downs, M. Crozier, B. Guy Peters, D. Flemming, V. Wriston, L. O’Tol), in particular, the lack of flexibility to external uncertain conditions, slow reengineering of business processes under the current realities of economic reality, the lack of motivation to develop the innovative potential of the subject; to study the impact of strong bureaucratic management on economic growth in the works of scientists of the late XX century. (P. Evans, D. Rauch); to reveal the contradiction in the XX century studies and prove that the bureaucratic organizational structure of management has a fading, sometimes stagnating influence on economic growth in the conditions of increasing economic uncertainty.Results. The paper investigated and found that the theory of the influence of the bureaucratic model on economic growth is confirmed on the example of 1960-2000. However, since the 2000s, which is proved in the research process, the bureaucratic organizational structure of management has a waning, sometimes stagnant effect on economic growth under conditions of increasing economic uncertainty. Consequently, bureaucratization of processes and bureaucratic organization is unable to respond to uncertainty. This is because the transition to the new century is marked by the introduction of the antipatterns of bureaucracy: digital technologies, artificial intelligence economy, flexible methods focused on situational management.Conclusions. The results revealed in this study prove the necessity of choosing a different type of organizational structure, not based on the bureaucratic model, in the conditions of permanent crisis and increasing uncertainty in the economy
Development of the circulation of digital financial assets in the world in the context of digital transformation
Authors: Ivleva E. S. , Makarov M. Yu. , Bobrov A. G. 
Published: April 2024

Aim. To study and describe the main trends in the development of the world market of digital financial assets in the conditions of digital transformation. Objectives. To disclose the essence and role of digital transformation at the present stage; to consider the emergence of digital financial assets and the possibilities of their application against the background of high growth rates of the cryptoasset market; to analyze the main indicators of digital currencies as of February 2024; to identify the key characteristics of the use of cryptocurrencies by different countries; to rank countries according to the index of cryptocurrency ownership for 2023; to describe the development trends of the circulation of digital financial assets in the world in the conditions of digital transformation.Methods. The study uses complex and logical approaches, general scientific methods (analysis, synthesis), methods of comparative and economic analysis, analytical processing and graphical presentation of information.Results. The leading trends in the development of the global market of digital financial assets in the conditions of digital transformation have been considered. The indicators of the top 10 largest digital currencies by market capitalization are highlighted. Based on the results of the study, the ranking of countries by the index of cryptocurrency ownership for 2023 was compiled. The main indicators of digital currencies for February 2024 were analyzed. The key characteristics of cryptocurrency use by different countries in the context of high rate of digital transformation were described.Conclusions. The results of the conducted research allowed us to conclude that the current transformation of the global economy, associated with the active development of breakthrough technologies, including distributed ledger technologies (DLT) and blockchain, has become a trigger for the emergence of digital financial assets and expanded the possibilities of their application in the context of high growth rate of the cryptoasset market. The analysis of the current state and development of the circulation of digital financial assets in the world under the conditions of digital transformation shows the growing interest in the use of cryptocurrencies and the introduction of blockchain technologies in the financial systems of various countries, as well as the growing use of cryptocurrencies by companies and individuals. Taking into account the review of global trends, development of fintech technologies, the conclusion is made about the inevitability of the processes of digitalization of financial assets, the emergence of new forms of digital assets, which dictate the need for advanced development of their legal regulation. In the future, the development of digital assets will give them the official status of a means of payment and expand their use in the system of financial relations in the conditions of digital transformation both in Russia and abroad.