bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Spatially Distributed Microneedle System for Bioorthogonal T Cell‐Guided Cancer Therapy
Authors: Li Lanya , Wang Fei , Mo Shushan , Deng Junyao , Wang Xueyi , Ai Jiacong , Xiao Yingxian , Zeng Yan , Li Qishan , Zhang Yixin , Cai Limin , Li Zhenhua 
Published: February 2025

AbstractChimeric antigen receptor (CAR)‐T cell therapy represents a promising strategy for cancer treatment. However, the diversity of solid tumor antigens and the poor infiltration of CAR‐T cells significantly hinder the efficacy of CAR‐T therapies against tumors. Here, a spatially distributed microneedle system (SDMNS) is developed that leverages bioorthogonal reactions to activate and guide endogenous T cells to tumors for effective destruction. The SDMNS consists of two dissolving microneedles, each loaded with complementary bioorthogonal groups and applied separately to lymph nodes and tumor sites. One microneedle loaded with two dibenzocyclooctyne (DBCO)‐modified antibodies activates T cells and labels them with bioorthogonal groups in lymph nodes. The other microneedle, containing N‐azidoacetylmannosamine‐tetraacylated (Ac4ManNAz) for glycometabolic labeling of tumor cells, and the T cell chemotactic factor IP10, is applied directly to the tumor site. The in vivo studies demonstrate that SDMNS effectively directs the migration and infiltration of endogenous activated T cells into the tumors. Through a bioorthogonal click reaction, DBCO‐modified T cells conjugate with azide (N3)‐modified tumor cells, eliciting robust antitumor immune responses and durable immune memory. The SDMNS offers a novel strategy to overcomes tumor heterogeneity by facilitating the directed migration of endogenous T cells.
A New Type Microwave Absorption Materials: Metal–Organic‐Frameworks (MOFs) Used as Non‐Conductive Material Combination with P‐C‐800
Authors: Han Guodong , Zhao Song , Sui Sai , Feng Bo , Wang Yudeng , Zhou Junxiang , Li Zhuolun , Tian Xiaoxia , Jia Yuxiang , Wang Jiafu , Qu Shaobo 
Published: February 2025

AbstractMetal–Organic‐Frameworks (MOFs) are commonly used as microwave‐absorbing materials after pyrolysis treatment. Rare researchers treat MOFs as non‐conductive materials and use them as absorbing materials directly. In this paper, MOFs@P‐C‐800 composite materials are prepared adopt to hydrothermal and ultrasonic dispersion methods by regulating the morphological characteristics of MOFs and the content of P‐C‐800. As for the Co‐BDC‐P‐C‐800, the maximum reflection loss reaches −18.4 dB at 14.29 GHz and the effective absorption bandwidth (EAB) achieves 3.87 GHz from 13.5 to 17.37 GHz. After the contents of P‐C‐800 is adjusted, the Co‐BDC‐P‐C‐800 (0.05 g) exhibited excellent microwave absorption performance, the maximum RL value of −60 dB at 13 GHz with a thickness of 2.0 mm, and the EAB achieves 5.91 GHz from 12.02 to 17.93 GHz. This paper not only provides new application direction for MOFs, but also offers a promising direction for the research and development of absorbing materials.
Structural Influence on Exciton Formation and the Critical Role of Dark Excitons in Polymeric Carbon Nitrides
Authors: Im Changbin , Beranek Radim , Jacob Timo 
Published: February 2025

AbstractPolymeric carbon nitrides (PCNs) exhibit intriguing optical properties and exceptional performance in (photo)catalysis, optoelectronics, and energy storage. Nevertheless, the intricate phenomena involving light absorption, formation of long‐lived excitons, photo‐charging, and photochemical processes observed in PCNs remain poorly understood. This theoretical investigation elucidates the origin of distinct dark and bright excitons, their stability and lifetimes, and their correlation with the microstructural attributes of PCNs. Based on these results, the decisive role of dark excitons in photocatalytic reactivity is proposed, which underlies the experimentally observed differences in the photocatalytic performance of various PCN derivatives. This study thus establishes novel insights into the factors governing the light‐driven processes in PCNs that can provide essential guidelines for rational design of PCNs with enhanced performance.
Revealing the Role of Ru‐O‐Ce Interface Coupling in CeO2‐Ru Aerogel for Boosting Hydrogen Evolution Kinetics
Authors: Fan Haoxin , Wan Xinhao , Sun Shougang , Zhou Xuemei , Bu Xiuming , Ye Jianqi , Bai Rui , Lou Hengwei , Chen Yao , Gao Jie , Zhang Jian , Gao Wei , Wen Dan 
Published: February 2025

AbstractDesigning heterogeneous interface to enhance the kinetics for electrocatalysts is a highly efficient but challenging pathway toward hydrogen evolution reaction (HER) in water electrolysis. Herein, the heterogeneous coupling of CeO2 quantum dots onto porous Ru aerogel through interfacial Ru‐O‐Ce bridge is proposed to construct CeO2‐Ru aerogel as the superior HER electrocatalyst with ultra‐low overpotentials. In situ characterizations and theoretical calculations reveal the electron distribution at the heterogeneous Ru‐O‐Ce bridge to boost hydrogen bonding at Ru sites, and the faster water adsorption and dissociation at the CeO2 sites to enhance the HER kinetics. Furthermore, CeO2‐Ru aerogel is employed as excellent cathodes for both acidic and alkaline water electrolyzers with ampere‐level current density and stably operated over 500 hours. Thus, the synergistic effect for CeO2‐Ru aerogel through the Ru‐O‐Ce bridge tunes the HER catalytic mechanism and reinforces the activity, realizing highly efficient hydrogen generation in water electrolysis.
Charge Carrier Dynamics at Heterojunction of Semiconductor Nanoheterostructures for Photocatalytic Solar Fuel Generation
Authors: Tsai Kai‐An , Chang Jui‐Cheng , Pu Ying‐Chih 
Published: February 2025

This review summarizes the investigation of semiconductor nanoheterostructures (NHSs) aimed at enhancing the efficiency of solar fuel generation through various time‐resolved spectroscopic techniques, including transient absorption spectroscopy (TAS), time‐resolved photoluminescence, and in situ TAS. These time‐resolved spectroscopies provide insights into the mechanisms of exciton and charge carrier dynamics at the heterojunctions of optimized semiconductor NHSs. The significance of these techniques underscores the necessity for designing effective photocatalysts and photoelectrodes for applications in photocatalytic water splitting and carbon dioxide reduction. Finally, the current challenges and future directions for studying charge carrier dynamics in semiconductor NHSs for photocatalytic solar fuel generation are outlined and discussed.
Mechanically mediated bulk atom transfer radical polymerization enabled by high‐performance piezoelectric Bi0.5Na0.5TiO3
Authors: Xiong Juan , Yu Ke , Wang Bing‐Hao , Huang Xin‐Yi , Tang Shu , Hu Qing , Guo Jun‐Kang , Tang Long , Yin Shuang‐Feng 
Published: February 2025

AbstractThis study presents the successful mechanically mediated bulk atom transfer radical polymerization (mechano‐ATRP) of methyl acrylate (MA) using the high‐performance piezoelectric material Bi0.5Na0.5TiO3 (BNT) under ultrasonic conditions. Compared to the widely used BaTiO3 in mechano‐ATRP, BNT demonstrates superior piezoelectric performance, enhancing carrier generation, separation, and interfacial transfer. The strong interaction between BNT and Cu catalysts facilitates the rapid capture of mechano‐induced electrons, leading to the formation of CuI/L and efficient polymerization initiation. Factors such as piezoelectric material loading, Cu catalyst loading, targeted degrees of polymerization, and sonication power were systematically evaluated. The living nature of ATRP was confirmed by polymers with predetermined molecular weights and low dispersitis (<1.2). This work broadens the application of ATRP and offers valuable insights into the design of piezoelectric catalytic materials for mechano‐ATRP.
Hydrogen‐bonded organic framework membranes through dispersion‐controlled deposition method for efficient CO2 separation
Authors: Wang Yuhan , Ren Yanxiong , Cao Yu , Zhao Junyi , Fu Jingqi , He Guangwei , Zhu Ziting , Sun Qian , Pan Fusheng , Jiang Zhongyi 
Published: February 2025

AbstractHydrogen‐bonded organic frameworks (HOFs) feature a highly ordered pore structure, abundant organic functional groups, and unique solution‐processability, holding great promise in gas separations. In this study, we explored the fabrication of HOF membranes utilizing a dispersion‐controlled deposition (DCD) method. To achieve homogeneous dispersion, the bulk HOF aggregates were initially dispersed in solvent and then switched to anti‐solvent to generate the precipitated nanoparticles. Under vacuum‐assisted assembly, the HOF colloidal solution containing nanoparticles was uniformly deposited, and the intracrystalline defects were spontaneously healed during the mixed‐solvent evaporation. For the first time, HOF polycrystalline membranes were fabricated on flexible polymer substrates and demonstrated an ultrathin HOF selective layer of ~100 nm. The prepared HOF membranes exhibited high separation performance, with the CO2 permeance exceeding 600 GPU and the CO2/N2 selectivity exceeding 30. This work establishes a platform technology for HOF membrane fabrication and expands the families of carbon capture membranes.
A murine model of aortic regurgitation generated by trans‐apical wire destruction of the aortic valve
Authors: Huang Xiaoxia , Wang Qiancheng , Han Dan , Lin Hairuo , Li Zhihong , Zheng Cankun , Bin Jianping , Liao Wangjun , Cong Zhanchun , Shen Mengjia , Liao Yulin 
Published: February 2025

AbstractBackgroundThe mechanisms underlying cardiac remodeling in aortic valvular (AoV) disease remain poorly understood, partially due to the insufficiency of appropriate preclinical animal models. Here, we present a novel murine model of aortic regurgitation (AR) generated by trans‐apical wire destruction of the AoV.MethodsDirected by echocardiography, apical puncture of the left ventricle (LV) was performed in adult male C57BL/6 mice, and a metal guidewire was used to induce AoV destruction. Echocardiography, invasive LV hemodynamic and histological examination were conducted to assess the degree of AR, LV function and remodeling.ResultsAR mice exhibited rapid aortic regurgitation velocity (424 ± 15.22 mm/s) immediately following successful surgery. Four weeks post‐surgery, echocardiography revealed a 54.6% increase in LV diastolic diameter and a 55.1% decrease in LV ejection fraction in AR mice compared to sham mice. Pressure‐volume catheterization indicated that AR mice had significantly larger LV end‐diastolic volumes (66.2 ± 1.5 μL vs. 41.8 ± 3.4 μL), reduced LV contractility (lower dP/dtmax and Ees), and diminished LV compliance (smaller dP/dtmin and longer Tau) compared to sham mice. Histological examination demonstrated that AR mice had significantly larger cardiomyocyte area and more myocardial fibrosis in LV tissue, as well as a 107% and a 122% increase of heart weight/tibial length and lung weight/tibial length, respectively, relative to sham mice.ConclusionsThe trans‐apex wire‐induced destruction of the AoV establishes a novel and efficient murine model to develop AR, characterized by significant eccentric LV hypertrophy, heart failure, and pulmonary congestion.
Enhanced Kinematics and Distribution Characteristics of Upper Scorpius and Ophiuchus Associations Based on Gaia DR3
Authors: Elsanhoury W. H. 
Published: February 2025

ABSTRACTThe kinematics within the solar vicinity have revealed interesting features relevant to both stellar and Galactic structures. This study examines three stellar associations in the Upper Scorpius and Ophiuchus regions, along with their sub‐samples among Gaia DR3. The calculated kinematics and velocity ellipsoid characteristics, including the mean spatial velocity components (U, V, and W; km s−1), yielding values of approximately (−5.84 ± 2.42, −16.14 ± 4.02, −7.31 ± 2.70; km s−1). USC and Oph associations velocity dispersion within the ellipsoid () was found to be (1.36 ± 0.02, 0.80 ± 0.01, 0.96 ± 0.01; km s−1), their mean solar motion () was determined to be approximately 18.62 ± 4.32 km s−1, convergent point coordinates () were (95.91 ± 0.09°, −44.42 ± 0.02°), and Oort's constants, yielding A = 17.80 ± 0.24 km s−1 kpc−1 and B = −9.61 ± 0.32 km s−1 kpc−1. Finally, the density distribution function per absolute magnitudes of USC and Oph associations is examined to obtain both luminosity and mass functions; their analysis revealed the absence of any peaks or dips as consistent with other recent studies.
Assessing the Indirect Nexus Between Green Human Resource Management and Employee Green Behavior: A Fuzzy DEMATEL Approach
Authors: Chowdhury Shah Ridwan , Islam Md Asadul , Guha Souman , Rahman Mahfuzur , Sanju Nehad Laila 
Published: February 2025

ABSTRACTGreen human resource management (GHRM) has become a proactive strategy to develop an ecological platform in the private sector. Because of stakeholder pressures and regulations, organizations are required to adopt and implement GHRM practices. Current literature indicates that various intervening mechanisms may intensify the role of GHRM practices on employee green behavior (EGB). However, there is a paucity of studies that assessed the role of multiple mediators based on inter‐assessment and prioritization to guide organizations in developing GHRM strategies. This study aims to fill this gap in the literature by examining 10 mediators identified from the literature and recommending the most influential ones based on expert opinions. Furthermore, to address the vagueness of human perceptions of GHRM practices, this study applied the fuzzy set theory and the decision‐making trial and evaluation laboratory method to obtain and analyze expert opinions. The analysis has revealed three key influential mediators out of nine that can positively influence the indirect nexus between GHRM practices and EGB. These three key mediators have the highest prominence and influential scores include environmental strategy (M7), employee environmental commitment (M2), and green organizational culture (M3). The originality of the paper lies in its theoretical, practical, contextual, and methodological contributions.
Antihyperglycemic Potential of Algerian Trigonella foenum‐graecum L. Seed Extract in Type 1 Diabetic Rats: Combined In‐Vivo Studies and In‐Silico Docking Analysis of Bioactive Phenolic Compounds
Authors: Chelbi Lilya , Habiba Ferhati , Aicha Rizi , Narimane Chelbi , Abdelmadjid Bairi 
Published: February 2025

Type 1 diabetes (T1D) poses a significant global health challenge, with current treatments often proving inadequate. This study provides a comprehensive evaluation of the antihyperglycemic effects of methanolic extract from Algerian Trigonella foenum‐graecum L. seeds (MEF) in type 1 diabetic rats, combining both in‐vivo and in‐silico studies: molecular docking and ADMET. Polyphenol compounds (PCs) identified. Twenty‐four male rats divided into four groups: control, normal and diabetic rats treated with MEF. T1D was induced via a single 50 mg/kg streptozotocin injection. MEF was administered orally at a dose of 400 mg/kg b.w. for 28 days, with measurements of body weight and fasting blood glucose. Histopathological examinations of pancreatic tissues were conducted post‐treatment. HPLC identified fifteen PCs. We found that six main PCs had strong binding affinities for the IR (−9.463 to ‐7.893 kcal/mol). The ADMET modeling indicated favorable drug‐likeness, oral bioavailability, and no toxicity risk. Significantly, diabetic rats treated with MEF exhibited a marked reduction in fasting blood glucose levels (494.67 mg/dl to 144.17 mg/dl; p < 0.001), along with an increase in body weight and improvements in the pancreatic islets of Langerhans. These findings suggest that MEF possesses substantial antihyperglycemic potential and may play a role in managing T1D complications.
Pituitary Apoplexy Presenting With Oculomotor Nerve Palsy and Headache as the Initial Symptoms: A Case Report
Authors: Hou Qifan , Xu Lixin , Yi Jing 
Published: February 2025

ABSTRACTPituitary apoplexy is a rare clinical syndrome. This report presents a case with initial symptoms of oculomotor nerve palsy and headache. A 48‐year‐old patient reported blurred vision in the right eye for 1 month, followed by a sudden onset of left eyelid ptosis and a 1‐day headache. Laboratory tests revealed normal pituitary function, except for an elevated growth hormone level (> 36.600 μg/L). Preoperative computed tomography (CT) and magnetic resonance imaging (MRI) scans indicated space‐occupying lesion in the sellar region. The lesion was subsequently resected via transnasal subtotal surgery. Histopathological and immunohistochemical analyses confirmed a pituitary adenoma with infarction. The patient received hydrocortisone preoperatively and prednisone and levothyroxine postoperatively. On the second postoperative day, the headache resolved, and the left eyelid regained normal function within 2 weeks. Pituitary apoplexy is extremely rare, with initial presentations of oculomotor nerve palsy being exceptionally uncommon. Early diagnosis and prompt surgical intervention are essential to preserve pituitary function and rapidly alleviate cranial nerve dysfunction.
The Determinants of Materiality Assessment Disclosures in the Sustainability Statements of Iberian‐Listed Companies
Authors: Morganho Catarina , Milánes‐Montero Patricia , Pérez‐Calderón Esteban 
Published: February 2025

ABSTRACTEffective January 1, 2024, the Corporate Sustainability Reporting Directive (CSRD) mandates that large corporations disclose sustainability data using the European Sustainability Reporting Standards (ESRS). This study investigates the materiality assessment disclosure (MAD) in Portuguese and Spanish corporations, focusing on its role as a foundation for meaningful sustainability reporting. This study analyzed annual reports from 45 major businesses (2018–2022) and employed content analysis and panel data methodologies to score an index that quantifies MAD levels. The results revealed an average MAD score, highlighting significant gaps in the materiality assessment processes and outcomes. Industry and board size were identified as influential variables in determining MAD levels. These findings underscore the lack of comprehensive consideration of the societal and environmental impacts. Enhanced transparency, accountability, and adherence to ESRS are urgently required to improve the quality and relevance of sustainability reporting.
Macro‐Level Climate and Minority Voice: How Indigenous Multiculturalism Relates to Collective Action
Authors: Gale Jessica , Yogeeswaran Kumar , Kende Judit , Osborne Danny , Vanderklei Mark , González Roberto , Sibley Chris G. , Green Eva G. T. 
Published: February 2025

ABSTRACTInequalities and discrimination against Indigenous minorities are pervasive in post‐colonial societies. Collective action is critical for Indigenous minorities to redress these injustices. Integrating research on collective action, macro‐level norms and multiculturalism, we argue that macro‐level climates characterized by non‐Indigenous endorsement of Indigenous multiculturalism policies are likely associated with Indigenous minorities’ collective action. Two multilevel studies in Chile (non‐Indigenous majorities N = 1132; Indigenous minorities N = 1160; 26 communities) and New Zealand (NZ) (non‐Indigenous majorities N = 12,136; Indigenous minorities N = 3484; 108 communities) reveal that non‐Indigenous macro‐level (i.e., aggregated) endorsement of resource‐based policies was related to increased Indigenous minorities’ reaction to injustices and collective action. Non‐Indigenous macro‐level endorsement of symbolic policies showed similar (albeit weaker) results in NZ, but not in Chile. Thus, macro‐level climates that endorse concrete measures to address power asymmetries are particularly effective at fostering Indigenous minorities’ collective action. Theoretical and practical implications are discussed.
Common ownership and competitive dissimilarity: A global perspective on competition and institutional ownership
Authors: Steinberg Philip J. , Hennig Jan C. , Oehmichen Jana , Heigermoser Judith 
Published: February 2025

AbstractResearch SummaryResearch highlights that common institutional ownership (an investor owning publicly traded shares in two rival firms) can reduce rivals' incentives to compete. So far, this literature focused on domestic market competition. However, competition also arises in global markets, and common owners invest outside their home countries. We integrate the perspectives of global market competition and cross‐national distance into a model of shared principals with rival agents and argue for a positive effect of common ownership on rivals' competitive dissimilarity in global markets. Moreover, we argue that the competitive intensity in joint regions amplifies, and the cross‐national distance between common owners and their firms mitigates this effect. We find support for our theorizing using a multi‐industry dataset with 1574 of the largest firms worldwide.Managerial SummaryWhen investors hold shares in two competing companies, it can reduce how aggressively those rivals compete. To avoid direct competition, these companies often adopt divergent strategic actions. Our research shows that this dynamic extends to how competitors behave in international markets. We also identify key boundary conditions to this effect: The effect weakens when competition within shared markets decreases and when the distance between the owned rivals and their common investor increases. For managers of globally operating companies, this highlights the need to consider not just competitors' strategies but also their ownership structure. Overlapping ownership could significantly influence competitive dynamics in global markets by shaping competitors' strategic approaches.
Direct‐Acting Antivirals Induce Lymphoproliferative Disease Response in HCV‐Infected Patients With Indolent B‐Cell Non‐Hodgkin’s Lymphoma: A Prospective Observational Study
Authors: George Monica , Mustafayev Khalis , Ahmed Sairah , Thomas Sheeba K. , Jiang Ying , Patel Krina , Torres Harrys A. 
Published: February 2025

ABSTRACTB‐cell non‐Hodgkin lymphoma (NHL) in one of the most serious extrahepatic manifestations of chronic hepatitis C virus (HCV) infection. No prospective studies have been conducted in the United States (US) on the impact of direct‐acting antivirals (DAAs) in HCV‐infected patients with indolent B‐cell NHL not requiring chemotherapy. In this prospective study, we evaluated the general characteristics of US patients with HCV‐associated indolent B‐cell NHL and the oncologic impact of only DAA treatment without systemic cancer therapy in those patients. We enrolled patients seen at our center during 2014–2021; we analyzed only chemotherapy‐naïve patients treated with DAAs. Patients who required immediate conventional treatment for lymphoma were excluded from the study. The primary endpoints were sustained virologic response at 12 weeks (SVR12) and lymphoproliferative disease response, classified as complete response, partial response, stable disease, or progressive disease. The secondary endpoints were overall response rate (ORR) of NHL, duration of response (DOR), overall survival (OS), and progression‐free survival (PFS). Nine patients met the study criteria and were analyzed. Most patients were male (n = 6), White (n = 6), younger than 65 years (n = 6), and non‐cirrhotic (n = 8); had HCV genotype 1 (n = 5); and had been infected for more than 30 years (n = 7). All patients achieved SVR12. Six patients (67%) had complete response, and 3 (33%) had progressive disease. The ORR was 67%. The median DOR was 51 months (range 16–81 months). The 5‐year DOR, OS, and PFS rates were 100%, 83%, and 67%, respectively. HCV‐associated NHL is a late extrahepatic complication of HCV. Infected patients with indolent NHL have an excellent virologic responses to DAAs and most of them experienced a favorable oncologic response after HCV eradication without chemotherapy.