bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategi Pengembangan Desa Wisata Rintisan Oleh Badan Usaha Milik Desa (Bum Desa) Di Desa Wisata Pandanrejo
Authors: Mubarok Malik , Hertati Diana 
Published: April 2024

Desa wisata merupakan salah satu kategori pengembangan pariwisata dalam Rencana Pembangunan Jangka Menengah Nasional 2020-2024. Desa Wisata Pandanrejo merupakan unit pariwisata BUM Desa “Lancar Jaya” yang mendapatkan Juara 2 desa wisata rintisan dalam suatu event nasional yaitu Anugerah Desa Wisata Indonesia (ADWI) 2021 yang diselenggarakan oleh KEMENPAREKRAF (Kementerian Pariwisata dan Ekonomi Kreatif). Sehingga dalam pengembangan Desa Wisata Pandanrejo sebagai desa wisata rintisan merupakan tanggung jawab BUM Desa “Lancar Jaya” dan Pengelola Desa Wisata Pandanrejo. Tujuan dilakukannya penelitian ini yaitu untuk mengetahui, mendeskripsikan, dan menganalisis tentang Strategi Pengembangan Desa Wisata Rintisan Oleh Badan Usaha Milik Desa (BUM Desa) Di Desa Wisata Pandanrejo.Pada penelitian ini menggunakan teknik pengumpulan data primer berupa wawancara kepada informan, observasi, serta dokumentasi. Analisis data yang digunakan yaitu pengumpulan data, penyajian data, kondensasi data, serta penarikan kesimpulan. Hasil penelitian menunjukkan bahwa dari delapan sasaran kajian BUM Desa “Lancar Jaya” bersama dengan Pengelola Desa Wisata Pandanrejo telah melakukan tujuh langkah strategi secara optimal dan satu strategi yang belum dilakukan secara optimal dalam pengembangan desa wisata rintisan di Desa Wisata Pandanrejo
Analisis Kinerja Dinas Pemberdayaan Masyarakat Dan Desa (Dpmd) Dalam Proses Penyaluran Bantuan Langsung Tunai Dana Desa (Blt-Dd) Kepada Pemerintah Desa
Authors: Yusriandi Rafit , Marefanda Nodi 
Published: April 2024

This study aims to analyze the performance of employees of the community and village empowerment offices of Simeulue Regency in distributing direct cash assistance for village funds (BLT-DD). The method used in this research is descriptive qualitative with the acquisition of data sources through observation methods, interviews, and documentation. The results of the research obtained based on aspects of productivity, service quality, responsiveness, responsibility, and accountability, show that the performance of the Community and Village Empowerment Office in Distributing Village Fund Cash Direct Assistance to Village Governments in Simeulue Regency shows maximum results. . This is based on the five aspects of standards that are indicators of the performance of government agencies that can be fully met. Although there are still some things that need to be addressed. However, overall, the performance of the Simeulue Regency Community and Village Empowerment Office (DPMD) can be said to be optimal.
PENGARUH LOAN TO DEPOSIT RATIO, NON PERFORMING LOAN, DEBT TO EQUITY RATIO, MANAJEMEN LABA TERHADAP KINERJA KEUANGAN BPD 2018-2022
Authors: Wahyuni Resita , Kartika Sari Nurshadrina , Ilmi Mainatul 
Published: April 2024

This research aims to analyze the influence of financial ratios and earnings management on bank financial performance which is projected using ROA. Financial ratios include LDR, NPL, DER. This research usesnon-probability sampling with typepurposive sampling to retrieve population data from the financial reports of Regional Development Banks registered with the OJK for 2018-2022. The data analysis methods used are descriptive statistics, classical assumption testing, multiple linear regression analysis, hypothesis testing and determinant coefficient analysis (R2). The results of this research show that the NPL variable partially influences financial performance, while the LDR, DER and earnings management variables have no influence on financial performance. Meanwhile, simultaneously the LDR, NPL, DER and earnings management variables have no effect on financial performance. Based on the results of the coefficient of determination (R2), the contribution of the independent variable to the dependent variable has a value of 34.1%.
Effect of Salivary Melatonin on Ionizing Radiation Worker and its Effect on Periodontal Disease
Authors: Waleed Shams K. , Mohammed Ahlam T. , Uthman Asmaa T. 
Published: April 2024

الخلاصة
المقدمة:- الاشعاع الايوني يشمل العلاج الإشعاعي والتصوير الطبي ،يستخدم على نطاق واسع في الطب المعاصر. يقلل العلاج بمضادات الأكسدة من الآثار السلبية للإشعاع (اختلال التوازن التأكسدي). يمكن أن تؤدي الزيادات في أنواع الأوكسجين التفاعلية بين المصورين الشعاعيين إلى زيادة أمراض اللثة. قد يقلل الميلاتونين من الإجهاد التأكسدي وبالتالي يساعد على حماية الأنسجة.
هدف الدراسة:- لتقييم تأثير الإشعاع على حالات اللثة لدى العاملين بالإشعاع وتأثير الإشعاع على مستويات الميلاتونين.
الطريقة:- تكونت عينة الدراسة من 40 رجلاً يعملون في مجال الإشعاع المؤين لمدة 5 سنوات أو أكثر. ضمت المجموعة الضابطة 40 رجلاً كانوا ممرضين أو عاملين في المختبر. تم جمع عينات اللعاب غير المستحثة من جميع الأشخاص لقياس الميلاتونين اللعابي. خضعت كلتا المجموعتين لفحص مؤشر البلاك النزيف عند الفحص وفقدان الارتباط السريري. , عمق الجيب اللثوي,
النتائج:-كانت معاملات اللثة في مجموعة الدراسة أعلى المجموعة الضابطة مع وجود فرق معنوي ، وكان مستوى الميلاتونين اللعابي في مجموعة الدراسة أقل من المجموعة الضابطة مع وجود فرق معنوي.
الاستنتاج:-يمكن أن يكون الإشعاع عاملاً مسببا لأمراض اللثة. يؤثر كل من الإشعاع والتهاب دواعم السن على علامات الميلاتونين اللعابية ، مما يشير إلى التهاب دواعم السن.
BRIDGING THERAPY RESULTS IN PATIENTS WITH ACUTE CALCULOUS CHOLECYSTITIS AND CONCOMITANT ISCHEMIC HEART DISEASE
Authors: Dinets A.V. , Kondratenko S.O. , Markulan L.Yu. , Holinko V.M. 
Published: April 2024

Introduction. Binding or bridging therapy (BT) suggests long-term administration of short acting anticoagulants (unfractionated heparin – UFH or low-molecular-weight heparin – LMWH) during preoperative preparation and early postoperative period in patients who had been receiving anticoagulation therapy (ACT) or anti-aggregation therapy (AAT) for a long time before surgery. The generalized data on the BT technique for urgent surgical interventions, particularly, in patients with acute calculous cholecystitis (ACH) and concomitant ischemic heart disease (IHD), is currently lacking. The aim of the work – to improve the BT technique in patients with ACH and IHD and to evaluate the results of its application.
Materials and methods. The study included 73 patients– 33 (45,2 %) women and 40 (54,8 %) men aged 57 to 81 years, on average 71,4 ± 0,7 years, who had received ACT or AAT before the hospitalization. All patients were admitted to hospital within 72 hours (from 6 to 65 hours) from the onset of the disease, on average 27.3 ± 1.5 hours. The catarrhal ACH occurred in 27 (37,0%) patients, phlegmonous – in 21 (28,8 %) patients, gangrenous – in 25 (34,2 %) patients. According to Tokyo Guidelines for the management of acute cholangitis and cholecystitis (TG13), 19 (26.0 %) patients had ACH I degree, 31 (42.5 %) patients– ACH II degree, 23 (31.5 %) patients – ACH III degree. There were 3 (4.1 %) patients with NYHA class I heart failure, 39 (53.4 %) patients with NYHA class II heart failure, 26 (35.6 %) patients with NYHA class III heart failure, and 5 (6.8 %) patients with NYHA class IV heart failure. The advanced tactics of bridging therapy was applied, which depended on several factors such as INR, aPTT, creatinine clearance, Lee-White’s bleeding time. The target points were the frequency of INR or bleeding time therapeutic range achieving, and the frequency of hemorrhagic complications.
Results and discussion. Immediately before surgery (laparoscopic cholecystectomy), the target (therapeutic) INR range >2 was obtained in 18 (90 %) patients among 20 patients who had previously received warfarin. Among them 2 (10.0 %) patients had INR in the range of 1.3-2.0, 12 (60.0%) patients had INR in the range of 2.1-3.0, and 6 (30.0 %) had INR >3.1. The target value of bleeding time >12 min was in 48 (90.6 %) patients among the patients (53 patients) who had received AAT earlier. The values of bleeding time in the range of 10-12 min were in 5 (9.4 %) patients, 12.1-14 min –in 42 (79.2 %) patients, >14 min – in 6 (11.3 %) patients. In general, INR and bleeding time values were within the therapeutic window in 65 (90.3 %) patients, and there was no patient with signs of hypercoagulation. In the postoperative period, the dynamics of INR and bleeding time values were similar and figured out at increase in the part of patients with INR 2.1-3.0 and bleeding time 12.1-14 min respectively.
ЧАСТОТА СТРЕСОВИХ ВИРАЗОК І ЇХ ЗАЛЕЖНІСТЬ ВІД КИСЛОТНОСТІ ШЛУНКОВОГО ВМІСТУ В ПЕРИОПЕРАЦІЙНИЙ ПЕРІОД У ДІТЕЙ
Authors: Iskra Lu.A. , Bilyaev A. V. 
Published: April 2024

Operative intervention is a strong stress, which creates the prerequisites for both exacerbation of chronic inflammatory processes of the mucous membrane of the stomach and duodenum, and the development of ulcers I erosions in previously conditionally healthy individuals - the so-called “stress-induced changes”.
The article presents historical recollections of the study of the problem. Also data are given on the incidence of stress-induced changes in the mucous membrane of the upper gastrointestinal tract, both in patients in the intensive care unit in the presence of a critical condition, and in persons undergoing postoperative rehabilitation, according to the results of the world’s largest randomized research.
Widespread aspects of pathogenesis are highlighted - emphasis on the role of mechanisms of hypoperfusion of internal tissues and the state of acidity of gastric juice as the primary causes of stress-induced changes in the mucous membrane of the stomach. The most informative methods of examination for the detection of erosive-ulcerative changes of the mucous membrane of the digestive tract are presented. Also, the results of studies of various methods of prevention and treatment of changes in the mucous membrane of the upper gastrointestinal tract are presented.
The problem of stress-induced erosive-ulcerative changes in the mucous membrane of the stomach and duodenum for pediatric surgery for a long time was not paramount. However, with the development of operational technology of treatment, the emergence of new methods to expand the scope of surgical intervention, the relevance of the latter began to grow. In addition, a separate role should be attributed to the development of market relations and the formation of a modern system of financing medical and diagnostic process.
CLINICAL-ANAMNESTIC AND ECHOCARDIOGRAPHIC MARKERS OF NEONATAL SEPSIS AT DIFFERENT GESTATION AGE OF NEWBORN
Authors: Kretsu Natalia , Koloskova Olena , Bilous Tetiana 
Published: April 2024

neonatal sepsis remains one of the leading causes of morbidity and mortality in the neonatal age. Theinvolvement of the myocardium in sepsis remains insufficiently studied, in particular in neonatology, where issues ofmyocardial dysfunction in neonatal generalized infection seem even more controversial, especially in neonatal sepsisat different gestational terms. Objective. To study specific clinical and anamnestic and echocardiographic parametersin infants depending on gestational age for optimization of the prognosis in neonatal sepsis. Material and researchmethods. To achieve this goal, we observed 57 newborns with a verified diagnosis of “Neonatal sepsis”. Group I (23patients – 40.3%) included newborns with a gestational age of 37-42 weeks, Group II – 34 premature infants (59.7%)with a gestation of up to 36 weeks. The latter group, depending on the gestational age, was divided into IIA subgroup,
which was formed by 21 prematurely born patients with NS with a gestational age of 32-36 weeks, and the IIB sub-group – 13 newborns born before 32 weeks of gestation. Research results. The analysis showed that the severity of the
impairment in the general condition of the examined newborns general condition was assessed as severe in 47.8% ofnewborns of group I, in 88.2% of cases in group II (PI: II <0.05), in 85.7% of representatives of subgroup IIA (PI:IIA <0.05) and in 92.3% of children of subgroup IIB (PI: IIB <0.001). It is shown that every third child (30.4%) ofgroup I, 67.6% of newborns of group II (PI: II <0.05), half (52.4%) of the representatives of subgroup IIA (PII: IIA<0.01) and all seriously ill patients (92.3%) of subgroup IIB (PI: IIB, IIA: IIB <0.05) required cardiopulmonaryresuscitation in the delivery room. Thus, in relation to full-term patients, the risk of this significant postnatal factorof emergency is likely to increase: for group II: OR - 4.77 (95% CI 2.63-8.68), RR - 2.17 (95% CI 1.57-3.0), AR =0.37; and for premature babies with a gestational age of less than 32 weeks (IIB subgroup), respectively: OR – 27.44(95% CI 11.73-64.19), RR – 7.55 (95% CI 5.58-10.21 ), AR – 0.65. The correlation analysis showed that in prematureinfants suffering from NS, the increase in the functional capacity of the left ventricular myocardium was associatedwith the female sex (for EF r = 0.94, P = 0.0001, for FS - r = 0, 94, P = 0.0001) and the number of days of inotropicsupport (for EF r = 0.68, P = 0.043, for FS - r = 0.71, P = 0.03). Conclusions. The analysis of echocardiographic
parameters in the group of premature infants revealed a direct correlation between the ejection fraction and cardio-vascular resuscitation immediately after birth (r = 0.64) and the duration of inotropic drugs (r = 0.68).
CLINICAL FEATURES OF ANXIETY DISORDER IN POST-COVID-19 SYNDROME AND FINDING OF ITS PREDICTORS
Authors: Boiko Dmytro 
Published: April 2024

the article summarizes and describes clinical features of anxiety disorders in post-COVID-19 syn-drome. Mental and neurological disorders occupy a leading place in the structure of post-COVID syndrome. Recent
studies indicate an increase in the incidence of anxiety disorders in individuals with COVID-19. However, no clini-cal or laboratory features of the post-COVID anxiety disorders have been identified. Therefore, our study aimed to
describe the clinical features of anxiety disorders in the post-COVID period and to develop a mathematical prog-nostic model to identify potential predictors of post-COVID anxiety disorder. We conducted a case-control clinical
study, which included 145 males and females, which were divided into 2 groups, namely: group 1 - patients whobecame ill with COVID-19 during the last 6 months and group 2 - persons who were not ill with COVID-19 duringthe last 6 months. The clinical interview included the registration of symptoms of the debut and the time of the debutrelative to the episode of COVID-19. The Beck anxiety inventory was used for the assessment of the overall level ofanxiety. The State-trait anxiety inventory was used to assess state and trait anxiety. Statistical analysis of the datawas performed using the program EZR Statistics 1.54. Anxiety disorders during the first 6 months after COVID-19develop more often than those who have not had the disease in the last six months. Patients who had COVID-19in the last 5-24 weeks have an increased risk of anxiety disorders during this period and therefore require closemedical supervision and sufficient awareness of the likely symptoms. People with a post-COVID anxiety disorderreported the presence of autonomic symptoms, including excessive sweating and tachycardia, a feeling of inneremptiness, as well as circadian rhythm disorders in the form of difficulty falling asleep and waking up at the desiredtime. It should be noted that the overall frequency of detection of anxiety disorders in the post-COVID period isincreasing. It has been established that the risk of developing post-COVID disorder decreases with knowledge ofthe fact of contact with an infected person before the COVID onset and increases with a heightened level of prior
personal anxiety. Circadian rhythm disorders, in particular sleep phase shift and abnormal fatigue, may be predic-tors of post-COVID anxiety disorder.
ANALYSIS OF THE USE OF MOBILE APPLICATIONS BY FOREIGN AND UKRAINIAN PHARMACIES WITHIN THE CONCEPT OF HOLISTIC MARKETING
Authors: Sakhnatska Nataliia , Aliekperova Nataliia 
Published: April 2024

digitalization of the pharmaceutical sector requires the use of modern marketing approaches to pro-vide pharmacies with quality and safe pharmaceutical care within the holistic concept of marketing management. A
promising direction of digital transformation of the retail market of medicines is the introduction of special mobileapplications in the activities of pharmacies, which become a safe and accessible platform for the sale of medicinesto the population.The main purpose of the study is to exercise the analysis of the features of pharmaceutical services provisionusing mobile applications to foreign and Ukrainian pharmacy chains.The study is based on the use of content analysis, analysis of electronic resources, system, and logical analysis,as well as of the modeling method.As the objects of the study, American pharmacy chains CVS Pharmacy and Walgreens, British Boots, and LloydsPharmacy were selected, as well as 10 pharmacy chains in Ukraine in terms of turnover in January-October 2020.It is revealed that the leading world leaders in the retail market of medicines have been using this digital tool
in their marketing activities for a long time. Unlike domestic pharmacies, applications of foreign pharmacies ad-ditionally provide such services as online registration for testing and vaccination against COVID-19, additional
opportunities for the visually impaired, drug disposal, and others. Among the studied Ukrainian pharmacy chainsby market share, only a half have mobile applications with various functions, among the most developed mobileapplications are “Like” from LLC “Apteka-Magnolia” (“Pharmacy-Magnolia”), “Pharmacy 911” and “AptekaDobroho Dnia” (“Good Afternoon Pharmacy”).An integrated model of a mobile application of a modern pharmacy has been developed, aimed at effective
interaction of all necessary functions to provide the population with high-quality, convenient, and available phar-maceutical care. Promising areas of further research are the justification of the feasibility of using certain functions
of mobile applications, as well as other digital tools, such as pharmacy websites, social media pages within theconcept of holistic marketing.The results of the study conducted may be useful to specialists in the pharmaceutical industry for use in practicalpharmacy.
PARAMETERS OF OXIDATIVE HOMEOSTASIS IN CHILDREN WITH TYPE 1 DIABETES DEPENDING ON DURATION OF THE DISEASE AND COMPLICATIONS
Authors: Shevchenko T. , Maidannyk V.G. 
Published: April 2024

The increase in the number of endocrine pathology in our time is most associated with the prevalence of diabetes mellitus, which is one of the medical and social problems of modern society. According to the International Diabetic Federation (IDF) in 2015, about 415 million people in the world suffer from diabetes mellitus (DM). The purpose of our work is to study the parameters of oxidative homeostasis in children with type 1 diabetes, depending on the duration of the disease and the late complications of type 1 diabetes.
Methods and materials. A total of 90 children with type 1 diabetes mellitus were diagnosed with age 13.59 ± 1.04 grams, 42 of them were girls and 48 boys with a disease duration of 4.68–3.49 grams. All children underwent treatment at the endocrinology department at the DKL No. 6, Kyiv. In the children we examined, we studied the indexes of oxidative homeostasis, namely, the products of LPO – MDA were de- termined according to the method of Stalin ID, the antioxidant system – SOD was determined according to the technique of Siroty T.V., catalase by the method of Korolyuk M.A., and reducing glutathione – by the method of Hymerha F.I. The research was conducted at the Research Institute of Experimental and Clinical Medicine of the O.O. Bogomolets NMU.
Result. We detected a reliable dependence of the level of malondialdehyde on the duration of type 1 diabetes mellitus. The level of malondialdehyde increased with an increase in the duration of DM 1 type. The level of SOD the first years of the disease increased, but for 5 years the disease was reduced. The level of catalase and glutathione with decreasing durability decreases. What can be said about the depletion of the AOS and the maintenance of OS performance at a high level. There was no reliable dependence on the presence of late complications and the level of indicators of oxidative homeostasis.
EFFECT OF POTENTIAL MEDICINAL PRODUCT ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITY ON THE FATTY-ACIDIC COMPOSITION OF THE VAGINE TISSUE AND BLOOD SERUM OF RATS WITH EXPERIMENTAL VAGINITIS
Authors: Onyshchuk L.V. 
Published: April 2024

The purpose of the study was to investigate the effect of a potential combined drug with antimicrobial and antiinflammatory activity on the fatty acid composition of lipids in vaginal tissue and blood serum of rats with simulated vaginitis.
Materials and methods. The study was conducted on 35 female rats of the Vistar line weighing 180-220 g. Animals were divided into 5 groups: 1 – intact animals, control; 2 –animals with simulated traumatic vaginitis (TV); 3 – TV + base for suppository; 4 – TV + study drug with antiinflammatory and antimicrobial activity in the form of vaginal suppository; 5 – TV + comparative product Neo-Penotran® (“Ekselstix Helske SL”, Spain) in the form of a vaginal suppository. The study drug contained ibuprofen, clotrimazole and metronidazole in the form of suppositories. Composition Neo-Penotran® contains miconazole and metronidazole. Basis of the both medicines was the same – Vitepsol. Determination of the fatty acid composition of lipids in the tissues of the vagina and serum was carried out using the gas chromatography method.
The results revealed 9 of the most informative fatty acids: of them meristic C14:0, pentodecan C15:0, palmitinic C16:0, stearic C18:0 related to saturated fatty acids (SFAs), and oleinic C18:1, linoleic C18:2, linolenic C18:3, arachidonic C20:4, which is the sum of unsaturated fatty acids (UFAs). Linoleic C18:2, linolenic C18:3, arachidone C20:4 LC are part of polyunsaturated fatty acids (PUFAs) and are characterized as essential.
Conclusions. The study results showed that there is a change in the total content of SFA, UFA and PUFA in the background of traumatic vaginitis: SFAs – 44.5%, UFA – 55.5% and PUFA – 31.9% versus 50.4%, 49.6% and 27.5% of lipids in the vaginal tissue in the control group. It was found that after administration of the study drug against the background of traumatic vaginitis, the normalization of the SFA ratio was 37.8%, the UFA 62.2%, and the PUFA – 44.4% compared to 43.3%, 56.7% and 35.4% serum lipids in the control pathology.
HYGIENIC SUBSTANTIATION OF A NEW PESTICIDES IN UKRAINE OXATHIAPIPROLIN AND FLUFENACET MAXIMUM ALLOWABLE CONCENTRATION IN THE WATER BODIES USED FOR HOUSEHOLD AND DOMESTIC WATER SUPPLY
Authors: Novokhatska O.O. , Vavrinevych O.P. , Zinchenko T.I. , Syrota A.I. 
Published: April 2024

To prevent and decrease negative impact of pesticides on population health, safe levels of its residues in the water should be substantiated. Taking into consideration the fact of absence of regulations in the water of ponds in Ukraine for such substances as oxathiapiprolin and flufenacet, the purpose of the work was hygienic substantiation of this new pesticides in Ukraine maximum allowable concentrations in the water of water bodies used for household and domestic water supply.
Taking into account the abovementioned, we have performed experimental studies to substantiate the hygienic standard of studied pesticides in the water using physical- chemical, organoleptic, photometric, chromatographic, and statistical analysis methods. As a result of experimental studies threshold concentrations of oxathiapiprolin and flufenacet were established by the influence: on organoleptic properties of water at the level of 0.02 mg/dm3 and 0.2 mg/dm3, on the general sanitary regimen of pond – 0.0002 mg/dm3 and 0.002 mg/dm3, and on sanitary-toxicological index of hazard – 0.2 mg/dm3 and 0.02 mg/dm3, correspondingly. The findings allowed us to establish a limiting index of hazard (general sanitary) and to substantiate scientific evidence-based MAC of oxathiapiprolin in the water at the level of 0.0002 mg/dm3 and flufenacet – 0.002 mg/dm3.