bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphorylation of tau protein based on the activity of kinases and phosphatases in various forms of synaptic plasticity
Authors: Tan Burak , Tufan Esra , Barutçu Özlem , Aslan-Gülpınar Ezgi , Dursun Nurcan , Süer Cem 
Published: March 2024

AbstractThe aim of this study is to show the relationship between the change in the strengthening of synaptic plasticity and tau phosphorylation and tau-kinases and phosphatase. The averages of the field excitatory-postsynaptic potential (fEPSP) and population spike (PS) in the last 5 min were used as a measure of LTP, LTD and MP. Total and phosphorylated levels of tau, kinases and phosphatases were evaluated by western blot and mRNA levels were evaluated by RT-qPCR. The stimulation of synapses by HFS and LFS+HFS increased the phosphorylation of total-tau and phospho-tau at the Thr181, Ser202/Thr205, Ser396 and Ser416 residues, and these were accompanied by increased enzymatic activity of Akt, ERK1/2. The increased phosphorylation of tau may mediate maintenance of LTP. If the increase in phosphorylation of tau cannot be prevented, together with inhibition of the subsequent LTP, this may indicate that the physiological role of hyperphosphorylated tau in synaptic plasticity may extend to pathological processes.
Aware and In Denial: Ali Smith’s Seasonal Quartet as Climate Fiction
Authors: van Amelsvoort Jesse 
Published: March 2024

With each of its four books named after a season, Ali Smith’s Seasonal Quartet (2016–20) is structured according to life’s cyclical time patterns. As with all of Smith’s fiction, these novels are characterised by metamorphosis and transition. The Seasonal Quartet, however, also registers a sense of loss, as when one of the characters in Autumn laments the time “[w]hen we still had seasons, not just the monoseason we have now.” In this paper, I take up these and other references strewn through the novels and propose to read these four novels as climate fiction. Rather than representing grand-scale destruction and dislocation, however, the Seasonal Quartet registers the minute disruptions of and changes in our everyday lives due to anthropogenic climate change. The narrative form of Autumn, Winter, Spring, and Summer shows how the conditions of life in the present are affected and altered by climate change, whether it concerns changing weather patterns, migration patterns, and so on. The novels house both characters who are acutely aware of the current crisis, as well as those who remain in denial; as novels, however, they do make visible the effects of humanity having entered the Anthropocene. The Seasonal Quartet, therefore, shows how the radically other of our planet’s ecological and meteorological systems has entered and started to shape human lives. If these novels disclose the loss of the world as we have known it, they also find a more hospitable home in the world of art. In art, there is connection and the potentiality of a new world.
ORHAN PAMUK’UN “MASUMİYET MÜZESİ” ROMANIN GÜRCÜCE ÇEVİRİSİNDEKİ AHLAKİ DEĞERLERİ YANSITAN SÖZCÜKSEL ÖĞELER
Authors: ŞENEL UZUNKAYA İlkiz 
Published: March 2024

Orhan Pamuk’un Masumiyet Müzesi adlı romanı 2008’de İletişim Yayınları tarafından Türkçe olarak yayımlanır. Kemal ile Füsun arasındaki aşk üzerinden şekillenen roman, Türk romanında işlenen sosyal statüleri arasında kalarak aşk yaşamaya çalışan çiftlerin merkeze alınmasının bir örneğidir.
41 yıllık roman serüvenini pek çok ödülle taçlandıran Orhan Pamuk, dünyaca tanınan bir yazardır. Türk edebiyatının ilk Nobel ödüllü yazarı olan Pamuk’un eserleri Gürcüce dahil olmak üzere pek çok dile çevrilmiştir. Eserlerinin çeşitli dillere çevrilmesinden dolayı yazar, farklı dillerde okuyucu bularak kendi kültürünün farklı kültürlerle buluşturur. O kültürdeki edinimini ise çeviri sayesinde gerçekleştirir. Orhan Pamuk’un eserleri ile çeviri sayesinde buluşan Gürcü okur, yazarın güncel eserlerini takip eder. Kültürlerarası iletişimi sağlayan çeviri, Gürcü toplumunun yazarı beğenerek okuması ve eserlerini severek takip etmesine olanak tanır.
Çalışmada, Masumiyet Müzesi’nin Gürcüce çevirisindeki “ahlaki değerleri ifade eden sözcüksel ögeler” konusunu incelenecektir. Orhan Pamuk’un Masumiyet Müzesi adlı romanını Gürcü diline çeviren Eǩaṭerine Aḫvlediani (ეკატერინე ახვლედიანი)’dir. Çalışmaya konu olan romanda geçen ahlaki değerleri ifade eden sözcüksel ögeler kaynak metinde (Masumiyet Müzesi) geçen cümleler ile erek metinde (უმანკოების მუზეუმი/ umanǩoebis muzeumi) geçen cümlelerle birlikte tablolar halinde verilecektir. Eserde geçen ahlaki değerleri ifade eden sözcüksel ögeler olumlu ve olumsuz olmak üzere iki başlık altında incelenecektir. Gürcüce-Türkçe (Ǩvanṭaliani, 2010) ve Gürcüce-Türkçe (Arısoy, 2010) sözlüklerinden faydalanılarak, tespit edilen kelimeler ise kelime anlamları ile verilmiştir.
Peregrinas modernas
Authors: Lopez Lema Silvina 
Published: March 2024

Desde la peregrinación a Santiago de Compostela de Jimena de Asturias junto a su esposo Alfonso III el Magno hasta la actualidad, las diferentes Rutas Xacobeas han contado con la presencia de mujeres. En los últimos años el número de mujeres ha superado al de varones entre las personas que recorren el Camino Inglés, indicando el alto grado de popularidad que la peregrinación ha alcanzado en la actualidad entre el género femenino. El objetivo del presente estudio consiste en determinar las principales motivaciones de las mujeres que realizan el Camino Inglés solas mediante el análisis de los factores push y pull de la experiencia durante la peregrinación. La investigación se ha basado en 699 encuestas efectuadas a personas que se encontraban realizando el Camino Inglés durante el año Xacobeo 2022. De la mencionada muestra se ha efectuado un análisis en profundidad respecto a las mujeres que realizaron el Camino solas, comparando en ciertos casos con las mujeres que viajan acompañadas o con el total de la muestra, para hallar similitudes y contrastes. Se ha continuado con un análisis exploratorio del gasto que estas mujeres tienen y, por último, se ha buscado conocer el nivel de satisfacción de dichas mujeres respecto a factores clave como son la hospitalidad y la seguridad.
Percepciones de los gerentes de hostelería de Macao sobre la sostenibilidad y la RSC
Authors: Calado Joao 
Published: March 2024

Este estudio examina las percepciones de los profesionales de la hostelería con experiencia en Macao con respecto a la Responsabilidad Social Corporativa (RSC) y las iniciativas de sostenibilidad dentro de la industria hotelera. Su objetivo es proporcionar información valiosa para futuras investigaciones y prácticas en el campo y explora si las percepciones de la RSC por parte de los profesionales de la hostelería tienen un enfoque predominante en alguna de las tres dimensiones de la sostenibilidad (ambiental, social y económica). Los datos se recolectaron a través de un cuestionario tipo escala Likert y utilizando un muestreo de conveniencia no probabilístico, seguido del método de bola de nieve. Se realizó un análisis de componentes principales para identificar las dimensiones de la triple bottom line relacionadas con la percepción de las iniciativas de RSC. También se realizó una entrevista semiestructurada con un experto en sostenibilidad en la industria hotelera de Macao para complementar la información obtenida de las encuestas. Los resultados sugieren que las tres dimensiones del triple bottom line (económica, ambiental y social) se percibieron como igualmente importantes sin diferencias significativas, y las iniciativas de RSC mejoran la identificación organizacional entre los gerentes de hoteles en Macao. Estos hallazgos pueden interpretarse como un indicador de que los gerentes de hoteles poseen una comprensión holística de los temas de RSC y sostenibilidad. Las limitaciones del estudio incluyen un tamaño de muestra pequeño y un enfoque en los profesionales de la hostelería en Macao, lo que podría limitar la generalización de los hallazgos. En general, el estudio subraya la importancia de las iniciativas de RSC y sostenibilidad en la industria hotelera, fomentando una integración más profunda de la triple bottom line en la gestión organizacional de hoteles y casinos en Macao.
A comparative evaluation of effect of nano-bio fusion gel and chlorhexidine Gel in patients with chronic periodontitis: A clinical study
Authors: Prasad Vaishnavi , Aeran Himanshu , Tuli Amrinder Singh 
Published: March 2024

: To assess the clinical effectiveness of nano bio fusion gingival gel and chlorhexidine gel as an adjunct to non surgical periodontal therapy for the treatment of chronic periodontitis.: 45 chronic periodontitis patients with atleast ≥ 5mm probing pocket depth were selected. Patients were divided into 3 groups. Group A received intrasulcular application of nano bio fusion gingival gel after oral prophylaxis, group B received chlorhexidine gel after SRP and group C received SRP alone. Clinical parameters such as plaque index, gingival index, modified sulcular bleeding index, probing pocket depth and clinical attachment level were recorded at baseline, 1 month and 3 months.: Intergroup analysis of all the clinical parameters showed clinically significant results between baseline, 1 month and 3 months. However, on intragroup analysis, the results were significant between baseline and 1 month in group B only.: Nano bio fusion gingival gel and chlorhexidine gel can be a good adjunct to phase 1 periodontal therapy for treating chronic periodontitis. All the clinical parameters measured were reduced from baseline to 1 month and 3 months.
Ultrasound-guided injection of corticosteroid versus placebo in management of plantar fasciitis
Authors: Vatsa Gaurav , Suman Saurabh , Anshuman Kumar 
Published: March 2024

: Plantar Fasciitis (PF) is a prevalent musculoskeletal condition causing heel pain, with approximately 1 million annual U.S. physician visits. It is more common in women, aged 45-64, and obese individuals. Diagnosis relies on clinical history and examination, and various treatments target pain relief, though consensus on the most effective modality is lacking. Corticosteroid injections are commonly used but pose risks. This six-month prospective randomized controlled trial with 50 individuals assessed the efficacy of corticosteroid versus placebo injections for resistant PF. Ultrasound-guided injections were administered, and outcomes were measured at 3 weeks and 3 months.: Results indicated significant improvement in pain scores, Ankle and Hindfoot scores, and plantar fascia thickness with corticosteroid injections compared to placebo. No serious adverse events were observed. Corticosteroids aim to reduce inflammation, and studies link decreased plantar fascia thickness to pain relief. Ultrasound guidance enhances precision in delivery. While some protocol limitations exist, this trial contributes valuable insights into the pharmacological effects of corticosteroids in PF treatment, aiding in evidence-based recommendations.
Calcar reconstruction in bipolar hemiarthroplasty for unstable intertrochanteric fractures
Authors: Jain Kamal , Barnwal Sanjay , Gaikwad Sanjay 
Published: March 2024

: The increasing popularity of primary bipolar hemiarthroplasty for comminuted and osteoporotic intertrochanteric femur fractures is well-documented. However, the absence of posteromedial calcar support due to fracture presents a unique challenge: implant instability and varus collapse. Existing solutions, relying on stem modifications or bone cement void filling, encounter limitations in cost-effectiveness and biomechanical performance.: This study evaluated the efficacy of posteromedial calcar reconstruction using autologous cortical grafts harvested from the extracted femoral head and neck in 30 patients with intertrochanteric femur fractures. Following strict inclusion and exclusion criteria, primary bipolar hemiarthroplasty was performed with meticulous graft implantation. Weight-bearing and range-of-motion exercises commenced on postoperative day 1. Functional and radiological outcomes were assessed at 12 months follow-up. The demographic distribution revealed a 50:50 split between patients above and below 75 years old. 73.33% (n=22) fractures were right-sided, and AO 31-A2.2 emerged as the most prevalent fracture pattern (46.67%, n=14). An acceptable functional and radiological outcome was achieved in 93.33% (n=28) patients. Two complications (superficial infection and implant breakage) resulted in unacceptable outcomes. Notably, the calcar grafts demonstrated robust healing in patients with favorable functional outcomes (Excellent and Good), as evidenced by a mean Harris Hip Score of 93.11 at 1 year follow-up. This study demonstrates the potential of a well-shaped, wedged autologous cortical graft harvested from the femoral head and neck as an effective strategy for calcar reconstruction in intertrochanteric femur fractures. This technique facilitates graft union, prevents implant subsidence, and offers enhanced biomechanical stability with optimal stress distribution. Furthermore, it eliminates the need for allograft or donor site morbidity, leading to reduced costs and patient burden.
“Cup-in-Cup” for revision cup in total hip arthroplasty – An innovative technique
Authors: Tawri Pratik Sunil , Jhunjhunwala H R , Joshi Ashwin Moha 
Published: March 2024

In a revision hip surgery with isolated poly-ethylene liner wear along with a stable acetabular shell involves difficult decision of revising the entire acetabular component or just the liner. However, unavailability of the similar poly liner in a high risk patient can be dealt with a novel technique of cup in cup by retaining the stable shell and cementing a polyethylene liner over it. A 77-year-old male came with complains of pain in the right hip and limp of 4 months duration after 17 years of a revision hip surgery. Poly-ethylene liner was found worn out intraoperative with both the metal shell and the stem very stable. Same company poly liner was not available. In order to prevent the extensive revision in a high surgical risk patient and to prevent the blood and the bone loss, a new Elite poly-ethylene cement cup was cemented over the old stable cementless metal shell. At 3 years short term follow up patient is able to walk pain free independently. The “cup-in-cup” technique with cemented PE cup into a retained well-fixed and well-positioned metal shell is a good technique in high surgical risk patients and gives promising result at short term follow up.
Przemoc, przymus i eskalacja we współczesnej rywalizacji strategicznej
Authors: Banasik Mirosław 
Published: March 2024

Celem badań było wyjaśnienie i scharakteryzowanie znaczenia przemocy, przymusu i eskalacji we współczesnej rywalizacji strategicznej. Główny problem badawczy wyartykułowano pytaniem: w czym wyraża się i charakteryzuje się przemoc, przymus i eskalacja we współczesnej rywalizacji strategicznej? W procesie badawczym wykorzystano analizę i krytykę literatury, obserwację nieuczestniczącą oraz studium przypadków. W rezultacie przeprowadzonych badan ustalono, że w rywalizacji strategicznej zawsze jest obecna przemoc i przymus. Są one swoistymi narzędziami oddziaływania międzynarodowego do osiągania określonych celów politycznych. Przymus jest użyciem siły w sposób ograniczony, demonstracją siły, lub użyciem sił zbrojnych i prowadzenie starcia zbrojnego. Przymus zawiera w sobie odstraszanie i wymuszanie. Eskalacja to wzrost intensywności lub zakresu sporu albo konfliktu pomiędzy dwiema stronami, który przekracza próg uznawany za istotny przez jednego lub więcej jego uczestników. Eskalacja jest zjawiskiem interaktywnym, zachodzącym pomiędzy dwoma (lub więcej) stronami konfliktu, które dążą do uzyskania jednostronnej przewagi. Eskalacji zapobiega się poprzez odstraszanie strategiczne lub posiadanie dominacji eskalacyjnej.
Fidelidad de los Estudiantes Hacia una Institución de Educación Superior Pública en México.
Authors: Figueroa Velázquez Juan Gabriel , Garrido Vega Miriam , Alcántara Hernández Ruth Josefina 
Published: March 2024

OBJETIVO: Verificar la relación de la calidad del servicio y del CRM con la lealtad de los estudiantes de una institución de educación superior en México. Por ello, necesitan aplicar herramientas como la gestión de la calidad y la gestión de las relaciones con el cliente (CRM) para asegurar su mejora continua y con ello, la fidelidad de sus clientes.
MATERIALES Y MÉTODO: Se desarrolló una investigación cuantitativa, explicativa y transversal, mediante el planteamiento de un modelo que cumplió los requisitos de validez convergente y discriminante, así como un nivel de ajuste aceptable, mediante la técnica del modelado de ecuaciones estructurales, utilizando el software Smart PLS 3.
RESULTADOS: El CRM tiene una relación positiva y significativa, aunque débilmente, con la fidelidad de los alumnos a la universidad, con lo cual la hipótesis 1 es respaldada.
CONCLUSIONES: Las dos hipótesis planteadas en el modelo encontraron respaldo, con lo que se verificó que el CRM y la calidad del servicio que ofrece la universidad en mención se relacionan positiva y significativamente con la lealtad de los estudiantes.
Health Education Intervention on Husbands’ Perception Towards Participation in Reproductive Health Services
Authors: Muhammad Sani Hadiza , Haruna Ibrahim Abdullahi 
Published: March 2024

Aims: The study was conducted to determine the effect of husbands' participation in reproductive health education on the spousal utilization of maternal health services in Kaduna North Senatorial District, Kaduna state.
Methods: A Quasi-experimental study design was used. The study group had a pre-intervention followed by an intervention (health education) of two sessions which lasted for thirty minutes each with an interval of four weeks between them. Then a post-intervention test after nine months. The researcher used a multistage sampling technique in the selection of towns and a systematic sampling technique for the selection of participants, a questionnaire was used to collect data.
Results: The result shows a statistically significant positive change in husbands’ perception regarding participation in their spouses’ utilization of reproductive health services (p<0.05) with mean change from 2.79±0.405 pre-intervention to 3.11±0.540 post-intervention.
Conclusion: Intervention improved husbands 'perception of participation in spouses' utilization of reproductive health services. The study recommended the integration of a module on husbands' participation in reproductive health services in the healthcare packages for prospective husbands and those with wives as well as those cohabiting to improve their perception and participation in reproductive health services.
Efforts to Increase Legal Awareness on Violent Behavior by Ende Residents in Surabaya City
Authors: Dewi Pulung Sari Retno , Suryawati Nany 
Published: March 2024

The legal system which is based on and inspired by the philosophical values of Pancasila, aims to improve the legal system in Indonesia. That is able to protect its citizens from all actions or behaviors that are contrary to humanity and justice. Therefore, Indonesian law contains elements of protecting implementing order, justice, and especially non-discrimination, especially from gender. The law creates a dignified society, which humanizes humans, upholds human values. The norms that live in society, become a basis for the formation of a rule. But the customs and habits that exist in ethnic groups in Indonesia have their own character. Violence cannot be identified in a particular society, but all humans can have a hard character. However, the existence of a belis or dowry, seems to give legitimacy that women have been bought. Therefore, through this community service activity, it focuses focuses on efforts to increase awereness of the law in the hope of minimizing the habit of violent behavior in the nomad community from Ende in the Surabaya city. This effort to increase awereness of the law is carried out through legal assistance regarding domestic violence in the Ende nomad community in Surabaya City. The assistance of representatives of Ende residents in Surabaya related to Law Number 23 of 2004 concerning Domestic Violence needs to be carried out intensively and massively. There is a decrease in the level of domestic violence in the families of Ende nomads in Surabaya.
Highlights:

Legal System Based on Pancasila: The legal system in Indonesia is inspired by the philosophical values of Pancasila, aiming to protect citizens and uphold humanity, justice, and non-discrimination, especially concerning gender.

Focus on Awareness and Minimizing Violence: Community service activity focuses on increasing awareness of the law to minimize violent behavior within the nomad community from Ende in Surabaya.

Intensive Legal Assistance: Representatives of the Ende residents in Surabaya provide intensive and massive legal assistance related to Law Number 23 of 2004 concerning Domestic Violence, resulting in a decrease in domestic violence in the Ende nomad families.

Keywords: Violent Behaviour, Belis Culture, Legal Awereness, Domestic Violence, Nomad Community
Enhancing Green Productivity in Rural Communities: Empowering Local Economy through Innovative Red Guava Derivative Products
Authors: Sari Wulandari Indah Apriliana , Saidi Ida Agustini , Fediyanto Niko 
Published: March 2024

This scientific article presents a community engagement initiative aimed at improving the local economy and promoting sustainable practices in the rural village of Kebaron, Indonesia. The study focuses on harnessing the potential of the abundant red guava fruit through the application of Green Productivity (GP) principles. The research team conducted a series of activities, including problem identification, potential product analysis, training sessions on red guava derivative production, and environmental education. The results demonstrated the successful development of innovative red guava derivative products such as red guava ice cream, leather, and juice. By involving the community and promoting environmentally friendly production techniques, the project contributed to the establishment of a sustainable and eco-conscious local industry. The findings highlight the importance of integrating GP concepts into rural communities, providing valuable insights for global researchers and professionals in the field of sustainable production and community empowerment.

Highlight:

Unleashing the potential: The abundant harvest of red guava in the village of Kebaron presents an opportunity to optimize its benefits for the local community by implementing the concept of Green Productivity (GP).
Innovative product derivatives: Through community involvement and education, the project focuses on creating innovative red guava derivative products such as ice cream, leather, and juice, showcasing the application of sustainable production practices.
Online promotion for wider reach: Leveraging the power of online media, the project emphasizes the effective promotion and sales of the red guava derivative products, tapping into a larger consumer base and highlighting the importance of environmentally conscious production practices.

Keyword:
Green Productivity, Red Guava, Community Engagement, Sustainable Production, Rural Economy