bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tokenomics in the Metaverse: understanding the lead–lag effect among emerging crypto tokens
Authors: Guan Chong , Liu Wenting , Yu Yinghui , Ding Ding 
Published: April 2024

AbstractThe convergence of blockchain and immersive technologies has resulted in the popularity of Metaverse platforms and their cryptocurrencies, known as Metaverse tokens. There has been little research into tokenomics in these emerging tokens. Building upon the information dissemination theory, this research examines the role of trading volume in the returns of these tokens. An empirical study was conducted using the trading volumes and returns of 197 Metaverse tokens over 12 months to derive the latent grouping structure with spectral clustering and to determine the relationships between daily returns of different token clusters through augmented vector autoregression. The results show that trading volume is a strong predictor of lead–lag patterns, which supports the speed of adjustment hypothesis. This is the first large-scale study that documented the lead–lag effect among Metaverse tokens. Unlike previous studies that focus on market capitalization, our findings suggest that trade volume contains vital information concerning cross-correlation patterns.
Psychometric network analysis of the Patient Health Questionnaire-4 (PHQ-4) in Paraguayan general population
Authors: Caycho-Rodríguez Tomás , Travezaño-Cabrera Aaron , Torales Julio , Barrios Iván , Vilca Lindsey W. , Samaniego-Pinho Antonio , Moreta-Herrera Rodrigo , Reyes-Bossio Mario , Barria-Asenjo Nicol A. , Ayala-Colqui Jesús , Garcia-Cadena Cirilo H. 
Published: April 2024

Abstract
Background
Depression and anxiety are two of the most prevalent and disabling mental disorders worldwide, both in the general population and in outpatient clinical settings.

Objective
This study aimed to analyze the psychometric properties of the Patient Health Questionnaire-4 (PHQ-4) based on network analysis metrics.

Methods
A total of 911 Paraguayans (23.71% women and 76.29% men; mean age 31.25 years, SD = 10.63), selected by non-probabilistic convenience sampling, participated in the study. Network analysis was used to evaluate the internal structure, reliability, and measurement invariance between men and women.

Results
The results revealed that the PHQ-4 is a unidimensional measure through Exploratory Graph Analysis (EGA). Reliability, through structural consistency, identified that 100% of the time, only a single dimension was obtained, and all items remained stable, as they were always replicated within the empirical dimension. The unidimensional structure has shown evidence of configural invariance; therefore, the network structure functioned equally among the different sex groups.

Conclusion
The PHQ-4 presented optimal preliminary evidence of validity based on its internal structure, reliability, and invariance between sexes. Therefore, it may be useful as an accurate and brief measure of anxiety and depressive symptoms in the Paraguayan context.
Embryotoxicity of fluconazole on developing chick embryos
Authors: Sattar Rao Zahid , Bilal Asif , Bashir Sadia , Iftikhar Anisa , Yaqoob Irfan 
Published: April 2024

AbstractBackgroundFluconazole is a first-generation triazole used as an antifungal treatment for skin, hair, and nail infections. The study aimed to assess the embryotoxicity and teratological effects of fluconazole on chick embryos. Fertilized eggs were divided into four groups: two experimental groups treated with different concentrations of fluconazole (0.1 ml/egg, 0.2 ml/egg) containing 12 and 11 eggs, respectively, one group treated with distilled water (10 eggs), and a control group (10 eggs) left untreated. The liquid form of fluconazole was administered on the 4th day of incubation, and observations were made on the 9th day.ResultsThere were different anomalies observed in them like hydrocephaly, microcephaly shorting of the beak, agenesis, Amelia, micromelia, anophthalmia, microphthalmia, and kyphosis. There were also observed the morphometric measurements with a difference of significant (p < 0.001) and (p < 0.01) in CR length, body weight, head circumference, eye circumference, forelimb, and hind limb. Different vital organ defects were also observed in histological studies. Fluconazole in various combinations has been found to cause embryotoxicity and teratological consequences in chick embryos.ConclusionThe current study showed that fluconazole is teratogenic in creating chick undeveloped organisms. The embryotoxic impacts were recorded on structural morphometric and graphic levels.
Ultra-wideband terahertz fingerprint enhancement sensing and inversion model supported by single-pixel reconfigurable graphene metasurface
Authors: Liu Bingwei , Peng Yan , Hao YuFan , Zhu Yiming , Chang Shengjiang , Zhuang Songlin 
Published: April 2024

AbstractThe molecular fingerprint sensing technology based on metasurface has unique attraction in the biomedical field. However, in the terahertz (THz) band, existing metasurface designs based on multi-pixel or angle multiplexing usually require more analyte amount or possess a narrower tuning bandwidth. Here, we propose a novel single-pixel graphene metasurface. Based on the synchronous voltage tuning, this metasurface enables ultra-wideband ($$\sim$$
∼
1.5 THz) fingerprint enhancement sensing of trace analytes, including chiral optical isomers, with a limit of detection (LoD) ≤ 0.64 μg/mm2. The enhancement of the fingerprint signal ($$\sim$$
∼
17.4 dB) originates from the electromagnetically induced transparency (EIT) effect excited by the metasurface, and the ideal overlap between the light field constrained by single-layer graphene (SLG) and ultra-thin analyte. Meanwhile, due to the unique nonlinear enhancement mechanism in graphene tuning, the absorption envelope distortion is inevitable. To solve this problem, a universal fingerprint spectrum inversion model is developed for the first time, and the restoration of standard fingerprints reaches Rmax2 ≥ 0.99. In addition, the asynchronous voltage tuning of the metasurface provides an opportunity for realizing the dynamic reconfiguration of EIT resonance and the slow light modulation in the broadband range. This work builds a bridge for ultra-wideband THz fingerprint sensing of trace analytes, and has potential applications in active spatial light modulators, slow light devices and dynamic imaging equipments.
Organizational Breast Cancer Data Mart: A Solution for Assessing Outcomes of Imaging and Treatment
Authors: Zuley Margarita L. , Silverstein Jonathan , Logue Durwin , Morgan Richard S. , Bhargava Rohit , McAuliffe Priscilla F. , Brufsky Adam M. , Bandos Andriy I. , Nishikawa Robert M. 
Published: April 2024

PURPOSE In the United States, a comprehensive national breast cancer registry (CR) does not exist. Thus, care and coverage decisions are based on data from population subsets, other countries, or models. We report a prototype real-world research data mart to assess mortality, morbidity, and costs for breast cancer diagnosis and treatment. METHODS With institutional review board approval and Health Insurance Portability and Accountability Act (HIPPA) compliance, a multidisciplinary clinical and research data warehouse (RDW) expert group curated demographic, risk, imaging, pathology, treatment, and outcome data from the electronic health records (EHR), radiology (RIS), and CR for patients having breast imaging and/or a diagnosis of breast cancer in our institution from January 1, 2004, to December 31, 2020. Domains were defined by prebuilt views to extract data denormalized according to requirements from the existing RDW using an export, transform, load pattern. Data dictionaries were included. Structured query language was used for data cleaning. RESULTS Five-hundred eighty-nine elements (EHR 311, RIS 211, and CR 67) were mapped to 27 domains; all, except one containing CR elements, had cancer and noncancer cohort views, resulting in a total of 53 views (average 12 elements/view; range, 4-67). EHR and RIS queries returned 497,218 patients with 2,967,364 imaging examinations and associated visit details. Cancer biology, treatment, and outcome details for 15,619 breast cancer cases were imported from the CR of our primary breast care facility for this prototype mart. CONCLUSION Institutional real-world data marts enable comprehensive understanding of care outcomes within an organization. As clinical data sources become increasingly structured, such marts may be an important source for future interinstitution analysis and potentially an opportunity to create robust real-world results that could be used to support evidence-based national policy and care decisions for breast cancer.
Attenuation of Bone Mineral Density Decline During Anemia Treatment With Methenolone Acetate in Myelodysplastic Syndrome
Authors: Ushimaru Shu , Sumi Hirofumi , Aso Mea , Fujishima Rie , Shiizaki Kazuhiro , Tominaga Naoto 
Published: April 2024

Abstract
In an aging society, addressing the risks and management of osteoporotic fractures is critical to reduce mortality. Similarly, the morbidity of chronic kidney disease and myelodysplastic syndrome increases with aging. The association between chronic kidney disease and fractures is well understood; however, recent reports have indicated an increased risk of incident osteoporosis in patients with prevalent myelodysplastic syndrome. In this case report, we present an older man with stage 4 chronic kidney disease complicated by myelodysplastic syndrome and progressive decline in bone mineral density. He was treated with methenolone acetate and darbepoetin for anemia caused by myelodysplastic syndrome. During anemia treatment, the decline in bone mineral density was attenuated overtime. The case findings suggest the potential association between the use of methenolone acetate as a synthetic anabolic steroid and attenuated decline in bone mineral density.
Maternal Graves Disease Postthyroidectomy With Fetal Thyrotoxicosis and Goiter
Authors: Fennell David , Walsh Jennifer , Cathcart Barbara , O’Donnell Colm P F , Hatunic Mensud 
Published: April 2024

Abstract
Fetal thyrotoxicosis is a rare condition with high morbidity and mortality. It may complicate pregnancies in women with a history of Graves disease (GD) when transplacental passage of maternal TSH receptor antibodies stimulate the fetal thyroid gland and cause hyperthyroidism. We report the case of a 34-year-old woman with a history of GD and prior thyroidectomy, where fetal thyrotoxicosis at 21 weeks of gestation was suspected due to prenatal ultrasound findings of cardiac failure and fetal goiter. She was treated with high-dose carbimazole and followed closely by a multidisciplinary team. Her baby was delivered in good condition at 34 weeks’ gestation and developed hyperthyroidism in the days after birth, which was successfully treated medically. This case highlights the importance of awareness of the condition among women with a history of GD, as well as the necessity for prompt diagnosis and treatment of this complex disease.
Concordance of Blood Glucose and CGM During a Pilot Trial of Automated Insulin Delivery in Type 1 Diabetes Pregnancies
Authors: Kaur Ravinder Jeet , Levy Carol J , Castorino Kristin , Wood-Wentz Christina M , Rizvi Shafaq R , Ozaslan Basak , O’Malley Grenye , Trinidad Mari Charisse , Levister Camilla , Church Mei Mei , Desjardins Donna , Ogyaadu Selassie , Reid Corey , Bailey Kent R , Doyle Francis J , Pinsker Jordan E , Dassau Eyal , Kudva Yogish C 
Published: April 2024

Abstract

Background
Customized and standard automated insulin delivery (AID) systems for use in pregnancies of women with preexisting type 1 diabetes (T1D) are being developed and tested to achieve pregnancy appropriate continuous glucose monitoring (CGM) targets. Guidance on the use of CGM for treatment decisions during pregnancy in the United States is limited.

Methods
Ten pregnant women with preexisting T1D participated in a trial evaluating at-home use of a pregnancy-specific AID system. Seven-point self-monitoring of blood glucose (SMBG) was compared to the closest sensor glucose (Dexcom G6 CGM) value biweekly to assess safety and reliability based on the 20%/20 mg/dL criteria.

Results
All participants completed the study with 7 participants satisfying the safety and reliability criteria with a mean absolute relative difference of 10.3%. Three participants did not fulfill the criteria, mainly because the frequency of SMBG did not meet the requirements.

Conclusion
Dexcom G6 CGM is safe and accurate in the real-world setting for use in pregnant women with preexisting T1D with reduced SMBG testing as part of a pregnancy-specific AID system.
Restoring Ovarian Fertility and Hormone Function: Recent Advancements, Ongoing Efforts and Future Applications
Authors: Tsui Elizabeth L , McDowell Hannah B , Laronda Monica M 
Published: April 2024

Abstract
The last 20 years have seen substantial improvements in fertility and hormone preservation and restoration technologies for a growing number of cancer survivors. However, further advancements are required to fill the gaps for those who cannot use current technologies or to improve the efficacy and longevity of current fertility and hormone restoration technologies. Ovarian tissue cryopreservation (OTC) followed by ovarian tissue transplantation (OTT) offers those unable to undergo ovarian stimulation for egg retrieval and cryopreservation an option that restores both fertility and hormone function. However, those with metastatic disease in their ovaries are unable to transplant this tissue. Therefore, new technologies to produce good-quality eggs and restore long-term cyclic ovarian function are being investigated and developed to expand options for a variety of patients. This mini-review describes current and near future technologies including in vitro maturation, in vitro follicle growth and maturation, bioprosthetic ovaries, and stem cell applications in fertility restoration research by their proximity to clinical application.
Angioarchitecture Classification and Treatment Modalities of Craniocervical Junction Arteriovenous Fistulas: A Cohort Study of 155 Patients
Authors: Song Zihao , Ma Yongjie , Tu Tianqi , Wang Jiachen , Wang Yinqing , He Chuan , Li Guilin , Zhang Peng , Hong Tao , Sun Liyong , Hu Peng , Ye Ming , Zhang Hongqi 
Published: April 2024

BACKGROUND AND OBJECTIVES:
Craniocervical junction (CCJ) arteriovenous fistulas (AVFs) are rare. Variability in clinical manifestations and treatment strategies for CCJ AVFs stems from differences in their angioarchitecture. Our study aims to categorize CCJ AVFs based on their angioarchitecture and explore the associated clinical features and treatment modalities for distinct CCJ AVF types.

METHODS:
The authors conducted a retrospective analysis of patients with CCJ AVFs treated at a single neurosurgical facility over the past decade. These patients were classified based on the angioarchitecture of their CCJ AVFs. The analysis included an evaluation of angioarchitecture, clinical characteristics, treatment strategies, and outcomes.

RESULTS:
The study included 155 patients, with a median age of 56 years, collectively manifesting 165 CCJ AVFs. Our classification identified 4 distinct CCJ AVF types: epidural AVFs (19 [11.5%]), dural AVFs (98 [59.4%]), radicular AVFs (33 [20.0%]), and perimedullary AVFs (15 [9.1%]). Further differentiation was applied based on the presence of pial feeders. The predominant fistula location was at cervical-1 (77.0%). Ascending intradural drainage (52.7%) and descending intradural drainage (52.1%) were frequently observed drainage patterns. Patients with dural AVF predominantly presented with venous hypertensive myelopathy, whereas patients with other types of CCJ AVFs showed a higher incidence of subarachnoid hemorrhage (P = .012). Microsurgery was the predominant treatment, applied in the management of 126 (76.4%) AVFs, whereas 8 (4.8%) AVFs exclusively underwent interventional embolization and 25 (15.2%) received a combination of interventional embolization and microsurgical treatment.

CONCLUSION:
CCJ AVFs can be distinguished based on the fistula location and the arterial feeders. Currently, microsurgery stands as the preferred treatment strategy for CCJ AVFs, whereas interventional embolization plays a distinctive role in cases with specific angioarchitecture or as a pretreatment measure before microsurgery.
CHD4 and SMYD1 repress common transcriptional programs in the developing heart
Authors: Shi Wei , Wasson Lauren K. , Dorr Kerry M. , Robbe Zachary L. , Wilczewski Caralynn M. , Hepperla Austin J. , Davis Ian J. , Seidman Christine E. , Seidman Jonathan G. , Conlon Frank L. 
Published: April 2024

ABSTRACT
Regulation of chromatin states is essential for proper temporal and spatial gene expression. Chromatin states are modulated by remodeling complexes composed of components that have enzymatic activities. CHD4 is the catalytic core of the nucleosome remodeling and deacetylase (NuRD) complex, which represses gene transcription. However, it remains to be determined how CHD4, a ubiquitous enzyme that remodels chromatin structure, functions in cardiomyocytes to maintain heart development. In particular, whether other proteins besides the NuRD components interact with CHD4 in the heart is controversial. Using quantitative proteomics, we identified that CHD4 interacts with SMYD1, a striated muscle-restricted histone methyltransferase that is essential for cardiomyocyte differentiation and cardiac morphogenesis. Comprehensive transcriptomic and chromatin accessibility studies of Smyd1 and Chd4 null embryonic mouse hearts revealed that SMYD1 and CHD4 repress a group of common genes and pathways involved in glycolysis, response to hypoxia, and angiogenesis. Our study reveals a mechanism by which CHD4 functions during heart development, and a previously uncharacterized mechanism regarding how SMYD1 represses cardiac transcription in the developing heart.
Iason Chandrinos, Πόλεις σε πόλεμο 1939–1945: Ευρωπαϊκά αστικά κέντρα υπό γερμανική κατοχή [Cities at war, 1939–1945: European urban areas under German occupation]
Authors: Kantzias-Rohde Alexander 
Published: April 2024

Review of Iason Chandrinos, Πόλεις σε πόλεμο 1939-1945: Ευρωπαϊκά αστικά κέντρα υπό γερμανική κατοχή [Cities at war, 1939–1945: European urban areas under German occupation]. Athens: Mov Skiouros, 2018. 568 pp.
Z dziejów przyjaźni polsko-ormiańskiej
Authors: Krzyżowski Tomasz 
Published: April 2024

FROM THE HISTORY OF POLISH-ARMENIAN FRIENDSHIP: THE CASE OF MARIA GROCHOLSKA (1917-1989)
Maria Grocholska (1917-1989) played a significant role in Polish-Armenian cultural relations during the Soviet era. Born in St. Petersburg to a Polish family, she studied Russian philology and Armenian philology in Leningrad. Her studies continued in Yerevan from 1940 to 1945, and from 1945 to 1948 she worked there as Professor Gurgen Sewak’s assistant. After abandoning the completion of her doctoral studies, she worked in primary and secondary schools in Armenia, where she taught Russian and Armenian. From 1955 to 1960, she taught Russian at the Academy of Theology in Etchmiadzin. She was a fervent advocate of the Armenian language during the Russification era. In 1962, she translated into Armenian Bohdan Gębarski’s essay on the Armenian genocide in the Ottoman Empire, titled List do starego tureckiego znajomego [A Letter to an Old Turkish Acquaintance], which resonated widely in Armenia. She also translated several literary works by Polish authors into Armenian, including Stanisław Lem’s well-known novel Solaris. She moved to Poland in 1969, where she taught Russian at a high school in Grodzisk Mazowiecki and assisted Bohdan Gębarski in translating literature from Armenian. Grocholska died in Warsaw. In March 1989, a solemn memorial service was held in Etchmiadzin in her honor performed by Catholicos Vazgen I.
O Ormianach w Jerozolimie (C. Mutafian, Jérusalem et les Arméniens: jusqu’à la conquête ottomane (1516), Les Belles Lettres, Paris 2022)
Authors: Pisowicz Andrzej 
Published: April 2024

ON ARMENIANS IN JERUSALEM (CLAUDE MUTAFIAN, JÉRUSALEM ET LES ARMÉNIENS: JUSQU’À LA CONQUÊTE OTTOMANE (1516), LES BELLES LETTRES, PARIS 2022)
The review concerns an album publication by Claude Mutafian, a French-Armenian historian, about the Armenian past of Jerusalem until the beginning of the 16th century. The reviewer highly values the author’s research competence and the aesthetic and editorial aspects of the work. He also notes a few Polish accents, including a critique of the claim about German origins of the author of Descriptio Terrae Sanctae (1422), Johannes Poloner.
Satisficing in Dentistry. Who decides? Who benefits? Part 3
Authors: Kelleher Martin , Lewis Kevin 
Published: April 2024

This series of articles challenges some popular myths about supposedly ‘ideal’ treatment plans and is designed to provoke reflection and stimulate debate. It explains the concept of ‘satisficing’ (as opposed to ‘maximizing’) in dentistry, and illustrates how subconscious bias and self-interests might lead supposed experts to promote arbitrary aspirational standards and confuse them with what the law expects (the Bolam Test standard) and what is genuinely in the best interests of an individual patient. It is argued that sound, patient-centred, pragmatic planning and treatment is equally valid, with wider applicability, than routinely defaulting to a self-serving ‘maximalist’ approach. CPD/Clinical Relevance: The ‘satisficing ‘concept has wide and profound application across many fields of clinical (and non-clinical) dentistry.
Dentifrices. Part 3: Dentifrice Recommendations
Authors: Valkenburg Cees , van der Weijden Fridus , Slot Dagmar Else 
Published: April 2024

This article, the third in a series about dentifrices, emphasizes the essential role of dentifrices in oral healthcare, highlighting their contributions beyond mechanical plaque removal to include plaque inhibition and delivery of therapeutic agents. Despite the sometimes-limited impact on mechanical plaque removal, the importance of fluoridated dentifrices, must not be underestimated. The article reviews the effectiveness and safety of dentifrices, including the challenges posed by subjective clinical indices and potential allergenic ingredients. It discusses the potential of innovative dentifrice formulations to improve compliance and oral health outcomes. Additionally, it emphasizes the critical role of dental care professionals in recommending dentifrices based on safety and effectiveness rather than cosmetic claims or cost. Through an analysis of the literature and clinical guidelines, this work aims to guide healthcare providers in making informed decisions about dentifrice recommendations for optimal oral health. CPD/Clinical Relevance: Dentifrices are complex formulations that need to be proven effective in (clinical) trials and be appreciated by end users.