bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Salicylic Acid and Jasmonic Acid-mediated Different Fate of Nickel Phytoremediation in Two Populations of Alyssum inflatum Nyár
Authors: Modarresi Masoud , Karimi Naser , Chaichi Mehrdad , Chahardoli Azam , Najafi-Kakavand Shiva 
Published: April 2024

Abstract

The availability of nickel (Ni) in root environment and its absorption by plants is a serious concern for plant products and human health. In stressful conditions, phytohormones such as salicylic acid (SA) and jasmonic acid (JA) play an essential role in modulating the physio-biochemical processes of plants. The current study was conducted to investigate Ni phytoremediation and accumulation potential in the presence of SA (0, 50 and 200 µM) and JA (0, 5 and 10 µM) in two populations of Alyssum inflatum, as a Ni-hyperaccumulator plant, under various Ni doses (0, 100 and 400 µM). Accordingly, by measuring Ni levels in shoot and root, values of bioaccumulation coefficient (BAC), biological concentration factor (BCF) and translocation factor (TF) were calculated to quantify Ni accumulation and translocation between plant organs. Furthermore, the amount of histidine (His), citric acid (CA) and malic acid (MA) as important chelators of Ni in shoots and roots were explored. The results displayed that plant mass and chlorophyll content declined in plants under high Ni concentration, while the amount of MA, CA and His increased. However, SA and JA moderated the harmful impact of Ni on physiological parameters and reduced organic acids and His contents in both populations. The values of phytoremediation indexes in both populations exposed to Ni (400 µM) were above one. In presence of the SA and JA, a decreasing trend was observed in these indexes. Overall, the results indicated that SA and JA could reduce phytoremediation potential in the two populations through different mechanisms.
Clinical application of the caudal-to-dorsal priority combined with cephalic approach in laparoscopic radical resection of right colon cancer
Authors: TengTeng Li , Xu Sun , HaiXiao Fu , Kai Wang , Wei Fu , Zhang Xuan 
Published: April 2024

Abstract
Objective The objective of this study is to examine the safety and feasibility of laparoscopic total colonic mesenteric resection for radical right hemicolectomy, utilizing a caudal-to-dorsal priority access approach in combination with a cephalic approach.Methods This study aims to conduct a retrospective analysis of the clinical data of 56 patients diagnosed with right hemi-colon cancer, who underwent radical right hemi-colon resection through laparoscopic total colonic mesenteric resection with caudal-to-dorsal priority, combined with cephalic approach, between January 2021 and June 2022.Results All 56 cases were completed without any instances of open surgery. The average operative time was (153.8 ± 42.5) minutes, with an average intraoperative bleeding of (53.3 ± 21.3) mL. The average time to first gas after surgery was (58.3 ± 13.6) hours, while the average time to return to a liquid diet was (68.5 ± 19.6) hours. The average postoperative hospital stay was (6.1 ± 3.0) days. Following surgery, two cases of lymphatic fistula and one case of anastomotic bleeding were reported. Following conservative treatment, all cases were cured, and no perioperative deaths were reported. Post-operative pathological results indicated that all cases were diagnosed with adenocarcinoma, with an average of 20.1 ± 5.9 lymph nodes cleared. Tumor staging revealed 8 cases in stage I, 19 cases in stage IIA, 11 cases in stage IIB, 12 cases in stage IIIA, and 6 cases in stage IIIB. During the 12-month postoperative follow-up, no instances of recurrence, metastasis, or death were observed.Conclusions The utilization of a caudal-to-dorsal priority in conjunction with a cephalic approach during laparoscopic radical resection of right hemicolectomy is a secure and viable method that aligns with the fundamental principles of radical oncology. This technique can aid in reducing the learning curve for surgeons performing laparoscopic right hemicolectomy and in guaranteeing surgical safety.
A fast and effective stiffness prediction method for Short Fiber Reinforced Composites with skin-core structure
Authors: Zhao Runtian , Wang Zhihui , Li Xiaodong , Gao Haifeng , Wu Ting , Li Yinhui , Liu Jianglin , Chen Zhanchun , Feng Jun , Liang Jianguo 
Published: April 2024

Abstract
The extrusion procedure used to manufacture Short Fiber Reinforced Composites (SFRCs) results in significant anisotropy in the components due to the skin-core structure. While there are existing accurate stiffness prediction methods available, there is still a need in engineering for an efficient and cost-effective prediction method. This work proposes an efficient, low-cost and effective stiffness prediction method for skin-core structure using the orientation averaging method and series-parallel model. Initially, the sample underwent analysis using industrial CT and metallographic microscopy to ascertain the fiber characteristics and skin-core dimensions. Furthermore, it is presumed that the skin and core are distinct materials, and their stiffness is determined using the orientation averaging method. Finally, the stiffness of the sample was determined by employing a series-parallel model for analyzing stress-strain transmission, which involved merging the skin and core components. Experimental and finite element results confirm the method's accuracy, boasting a calculation time of 31.36 seconds and a maximum stiffness error below 10%. This method is expected to be applied to automotive, construction, and other engineering fields to meet the demand for fast, cost-efficient, and effective stiffness prediction of SFRCs.
Changes of fatty acid metabolism in FA 26:0, FA 22:2 and FA 24:1 are associated with leukoaraiosis in the elderly
Authors: Song Yige , Lin Feng , Cao Hongli , Song Wangting , Liao Fengye , Deng Yanping , Wu Ning , Hong Weimin , Fat Tin Agassi Sze , Chen Xianyang 
Published: April 2024

Abstract
Background:
Cerebrovascular diseases in the elderly are associated with abnormal lipids metabolism. Although cerebral small vascular disease like Leukoaraiosis (LA) is reported to be common among the elderly with occurrence and progression of neurological disease, there are no effective treatments and even biomarkers screening for LA due to the limited understanding of its biochemical processes. Here, we employ untargeted and targeted lipidomic strategies to provide insights into LA onset associated with lipid disturbance.
Results:
A total of 122 participants were recruited, following exclusion criteria and propensity score matching, the final cohort consisted of 16 LA patients and 18 control subjects (CK). Untargeted lipid profiling identified 50 significantly different metabolites between LA and CK groups. Pathway enrichment and structural equation modeling demonstrated that fatty acid (FA) metabolism had significant impacts on LA onset. Compared with CK group, targeted free fatty acid (FFA) profiling revealed a significant decrease of FA C22:2 as well as FA 24:1 and increase of FA 26:0 in LA group, which were proved as potential biomarkers by logistic regression and decision curve models. WGCNA coupling with correlation analysis unveiled FA 26:0 mainly came out of ceramide (18:1/26:0), and FA 24:1 was initiated from phosphatidylcholine hub-transformed by lysophosphatidic acid (20:5), and FA 22:2 was mainly generated through glycerolipid.
Conclusion:
Our results demonstrated potential FFA biomarkers for LA screening, and illuminated preliminary metabolism process from lipid disturbance to FFAs alternation in LA patients, implying regulation of FA 26:0, FA 22:2 and FA 24:1 constituting in-depth mechanism for further studies of LA.
Role of PPAR modulators on seizure control and neurobehavior in status epilepticus model in rats
Authors: Sinha Surabhi , Sarangi Sudhir Chandra , Sharma Deeksha , Pattnaik Soumya Sucharita , Arora Ankit , Nag Tapas Chandra , Nambirajan Aruna , Tripathi Manjari 
Published: April 2024

Abstract
This study explored the impact of peroxisome proliferator-activated receptor modulators (PPAR-m) on seizure control and epileptogenesis in a lithium-pilocarpine-induced status epilepticus (SE) model in Wistar rats. Following optimal dose determination, the effects of fenofibrate, pemafibrate, and saroglitazar alone and with antiseizure medications were examined, including seizure evaluation and neurobiological assessments on day-21 post-SE induction. The optimal doses found for fenofibrate, pemafibrate, and saroglitazar were 200, 1.5, and 3 mg/kg, respectively. Drug-treated groups exhibited improved seizure control, memory-impairment attenuation, reduced neurodegeneration, astrocyte activation, myelin, and axonal damage, along with elevated protein (PPAR-α and HMGCS2) expression, and lower levels of epileptogenesis markers compared to SE-control (p<0.001). Perampanel+PPAR-m and fenofibrate+valproate exerted improved seizure control, lesser neurodegeneration, reactive astrocytes, and higher HMGCS2 protein expression compared to ASMs alone. PPAR-m adjuvant therapy with valproate and perampanel has significant seizure control and neuroprotective potential as compared to ASM alone treatment in SE.
Assessing the impact of apnea duration on the relationship between obstructive sleep apnea and hearing loss
Authors: Jo Yong Seok , Lee Jeon Mi 
Published: April 2024

Abstract

The relationship between obstructive sleep apnea (OSA) and hearing loss (HL) remains uncertain. We examined this association by retrospectively reviewing 90 patients diagnosed with OSA who underwent overnight polysomnography (PSG) and pure-tone audiometry. Patients with OSA were compared with non-OSA individuals, identified via the STOP-BANG questionnaire (SBQ) and age-sex 1:1 matching. The results indicated elevated hearing thresholds across all frequencies in the OSA group. Further categorization of patients with OSA into HL and non-HL groups revealed a significant increase in apnea duration in the HL group for all-frequency and high-frequency cases (p=0.038, 0.006). Multiple linear regression, adjusting for age and sex, revealed a significant influence of apnea duration on HL in both all-frequency and high-frequency cases (ß=0.404, p=0.002; ß=0.425, p=0.001). These findings underscore the reduced auditory function in patients with OSA and highlight the potential of apnea duration as a marker of chronic hypoxic damage linked to OSA.
Tackling Misinformation in Mobile Social Networks A BERT- LSTM Approach for Enhancing Digital Literacy
Authors: Wang Jun , 王 俊 , Yu Airong 
Published: April 2024

Abstract

The rapid fusion of mobile Internet with the media industry has exponentially accelerated the production and dissemination of misinformation, significantly impacting society. Mobile social networks, in particular, act as fertile grounds for the rapid spread of false news, demanding innovative oversight mechanisms to mitigate this digital epidemic. Our study introduces a robust detection model for false news in mobile social networks, leveraging the synergistic capabilities of Bidirectional Encoder Representations from Transformers (BERT) and Long Short-Term Memory (LSTM) networks. BERT's prowess in contextual word vector extraction, combined with LSTM's sequential data processing strength, provides a nuanced understanding of news content authenticity. We present empirical evidence showcasing the superior performance of our model, which outstrips conventional classifiers like random forest and logistic regression, with an impressive accuracy of 93.51%, recall of 91.96%, and an F1 score of 92.73%. Beyond mere detection, our approach advocates for the empowerment of users, fostering enhanced digital literacy through the development of critical skills necessary to discern credible information. By integrating BERT and LSTM, our model not only effectively flags misinformation but also serves as an educational tool, guiding users towards informed decision-making in the realm of mobile social networks. This research underscores the pivotal role of advanced computational techniques in the fight against misinformation, spotlighting the transformative potential of AI in bolstering digital literacy in an era inundated with ambiguous information.
Plasma B-type natriuretic peptide is independently associated with cardiovascular events and mortality in patients with chronic kidney disease
Authors: Hayashida Hiroyuki , Haruyama Naoki , Fukui Akiko , Yoshitomi Ryota , Fujisawa Hironobu , Nakayama Masaru 
Published: April 2024

Abstract

The association between B-type natriuretic peptide (BNP) and cardiovascular (CV) events and mortality have not been well characterized in patients with chronic kidney disease (CKD). We prospectively investigated whether BNP was associated with CV events or mortality beyond cardiac alterations in 1,078 patients with CKD. Participants were divided into the following 3 groups according to circulating BNP concentration: <40 pg/mL, low; 40–100 pg/mL, middle; and > 100 pg/mL, high. Primary outcome was fatal or nonfatal CV events, and alternative outcome was a composite of fatal or nonfatal CV events, or non-CV deaths. During a median follow-up of 2.6 years, CV and composite events occurred in 158 and 248 participants, respectively. Cox analyses after adjustment for covariates, including cardiac parameters, showed that the hazard ratios (HRs) (95% confidence intervals [CIs]) for CV events of middle and high groups were 0.99 (0.62, 1.57) and 1.68 (1.03, 2.74), respectively, compared with low group. Additionally, similar results were obtained for composite events; the HRs (95% CIs) of middle and high groups were 1.12 (0.78, 1.61) and 1.53 (1.03, 2.28), respectively, compared with low group. Thus, in CKD, high BNP concentrations were independently associated with CV events and mortality, independent of cardiac alterations.
The evolution of spatial and temporal distribution of rainfall erosivity in Henan Province, central China
Authors: Sheng-feng WANG , Xin-miao XU , Long-wei LEI 
Published: April 2024

Abstract
With the development of urbanisation, arable land has been drastically reduced and soil has been eroded, which has a negative impact on the food economy and agricultural development in some areas. Henan Province covers four basins, the Yangtze River, the Yellow River, the Huaihe River, and the Haihe River, with complex water conditions, and is a key agricultural region in China. Therefore, this paper uses 53 years of day-by-day rainfall data from 1969–2022 at 112 rainfall stations in Henan Province, and adopts the Zhang Wenbo erosivity model and the rainfall erosivity model of the First National Water Conservancy Census to calculate the erosive power of rainfall and combines with the multi-year The average rainfall was analysed using the Kriging interpolation method in the Geostatistical Wizard of ArcGIS, and the corresponding spatial distribution maps of rainfall and rainfall erosive force were derived. Wavelets and Mann-Kendall were used to analyse the fact of sudden changes, trends and cycles of rainfall and rainfall erosivity in the study area. Theresults show that the average rainfall (1969–2022) in Henan province is 718.26 mm, and the average rainfall erosivity (R) is 3213.46 MJ·mm/(hm2·h). R values are positively correlated with rainfall intensity and amounts, and show an upward trend year by year. The spatial distribution of R shows a gradual increase from northwest to southeast, which is closely related to the topography. There is a cyclic change in the rainfall in the study area, with the first primary cycle being the first cycle in every 53 years. The results of the study can be useful for other regions in central China.
The carpal tunnel syndrome caused by Arthrinium phaeospermum infection: first case report and literature review
Authors: Li Miaozhong , Li Yuning , Xueyuan Li 
Published: April 2024

Abstract

Background: The carpal tunnel syndrome(CTS) caused by atypical infectious is a therapeutic and diagnostic challenge. Because non-specific clinical presentation often result in misdiagnosis and incorrect therapy, failing to elicit an accurate exposure.
Case presentation: This article reports a case of deep infection leading to CTS manifestations. A male patient was admitted for numbness and pain of the left hand. Left carpal tunnel release, median nerve decompression, synovectomy of the carpal tunnel were performed. Inflamed synovium and effusion were submitted for bacterial culture and metagenomic next-generation sequencing(mNGS). The causing pathogen was identified as Arthrinium phaeospermum and the patient recovered after surgical debridement and 10 months of antimicrobial therapy.
Conclusions: Diagnosis of fungi infection of the hand is challenging as the presentation mimics other conditions without much histological findings. NGS is proposed of great importance adjunctive diagnostic approach for identifying atypical infectious quickly.
3D-printed Patient-Specific Implants made of Polylactide (PLDLLA) and β-Tricalcium Phosphate (β-TCP) for Corrective Osteotomies of The Distal Radius
Authors: Jakimiuk Adam , Maintz Michaela , Müller-Gerbl Magdalena , Thieringer Florian M. , Keller Marco , Guebeli Alissa , Honigmann Philipp 
Published: April 2024

Abstract

The most common surgical procedure to manage the malunion of the bones is corrective osteotomy. The current gold standard for securing the bone segments after osteotomy is the use of titanium plates and allografts which has disadvantages such as possible allergic reaction, additional operations such as extraction of the graft from other sites and removal operation. The utilization of resorbable materials presents an opportunity to mitigate these drawbacks, but has not yet been thoroughly researched in literature. This study assesses viability of using biodegradable, 3D-printed patient-specific implants made of Poly(-L-lactide-co-D,L-lactide) (PLDLLA) and β-Tricalcium Phosphate (β-TCP) as an alternative material in an in-vitro biomechanical study involving ex vivo biomechanical compression testing, biodegradation testing, and calorimetric measurements.. These implants possess a unique shape, resembling a wedge and are fixated as a connection between the osteotomized bone using resorbable screws. Following point-of-care virtual planning, bio-mechanical compressive tests with (n = 5) ex vivo radii equipped with PLDLLA/ β-TCP implants were performed to prove sufficient stability of the connection. All PLDLLA/ β-TCP implants withstood a compressive force of at least 1’211 N which exceeds the maximum force reported in literature in case of a fall from the height of 1 m. Furthermore, the results showed a consistent surface chemistry and slow degradation rate. The outcomes are encouraging, establishing the groundwork for an innovative distal radius corrective osteotomy surgical method. However, further research is necessary to thoroughly evaluate the long-term biodegradability and mechanical efficacy of the implants.
Effect of packaging on tourism perception in drug tourism: moderating effect of anti-drug information
Authors: Shim Jimin , Lee Won Seok , Moon Joonho 
Published: April 2024

Abstract

The aim of this research is to scrutinize the behavioral characteristics of tourists who engage in drug tourism. This research explores the relationships among packaging, antidrug information, attitudes, and behavioral intentions in the domain of drug tourism. This research employed antidrug information as the moderating variable. This research collected the data using a survey via the clickworker platform. The number of valid observations was 200. To test the research hypotheses, this work implemented the Hayes process macro Model 7. The results showed that packaging positively impacts both attitudes and behavioral intentions. Additionally, antidrug information significantly moderates the association between packaging and attitude. Moreover, attitude exerts a positive effect on behavioral intention. This research sheds light on the literature by presenting the behavioral characteristics of tourists in the case of drug tourism. Additionally, the practical implications of this work are discussed.
Prediction model for weight control experience in Korean men with obesity in their 30s and 40s
Authors: Han Myeunghee 
Published: April 2024

Abstract

Background
Obesity is an abnormal and potentially dangerous condition caused by excess body fat accumulation. The number of people with obesity is increasing worldwide. Obesity is the primary cause of various diseases; therefore, it is crucial to make efforts to control and maintain a healthy body weight. Identifying the factors that influence men with obesity to attempt to control and not control their weight is essential. The objective of this study was to create a prediction model for weight control experience among Korean men in their 30s and 40s.
Methods
We analyzed data from the 2022 Community Health Survey and included 12,311 men who were overweight or obese. The men were divided into two groups based on their weight control experience: 1) Yes group (n = 9,405) and 2) No group (n = 2,906). Chi-square and independent t-tests were used to compare general and health-related characteristics between the groups. Decision tree analysis was used to build a prediction model for weight control experience. A split-sample test was conducted to validate the model.
Results
Several predictive models were generated based on the total number of participants, age, and body mass index as the first separating factors. The major factors affecting weight control among men with obesity in their 30s and 40s in Korea include subjective body shape, age, body mass index, education level, completion of hypertension management education, awareness of blood glucose levels, and smoking status. Subjective body shape was confirmed to significantly affect weight control experience.
Conclusions
It is necessary to support individuals in maintaining and managing an ideal weight by promoting a desirable perception of their body shape. In addition, there is an urgent need to provide obesity prevention and management education to those who have no weight control experience, particularly those at high risk, as identified in this study.
Operative Treatment of Isolated Epiphyseal Fracture of The Distal Fibula：1 Case Report and Literature Review
Authors: Jiang Zhongbo , Yue Liang , Wang Deheng , Liang Yanchen , Jing Cheng , Guo Yanbo 
Published: April 2024

Abstract
Ankle injuries are the most common pediatric injury. Ankle epiphyseal fractures are also common in children, but isolated distal epiphyseal fibular fractures of the distal fibula are clinically rare. We describe one unusual case of an adolescent with a completely displaced Salter-Harris type II distal fibular epiphyseal fracture. The attempt of closed reduction failed, and the patient required open reduction and internal fixation. The localized periosteum and the superior peroneal retinaculum were avulsed from the distal fibular metaphysis, with the peroneal tendons underneath exposed but no obvious subluxation. To the best of our knowledge, this combination of injuries has not been previously reported.