bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Environmentally Friendly Electrochemical Method for Synthesis of Benzofuranoquinone Derivatives.
Authors: Davarani Saied Saeed Hosseiny , Shamsipur Mojtaba , Nematollahi Davood , Ramyar Somayyeh , Masoumi Leila 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Design and Synthesis of Hepatoselective, Pyrrole‐Based HMG‐CoA Reductase Inhibitors.
Authors: Pfefferkorn Jeffrey A. , et al. et al. 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Design, Synthesis, and Evaluation of 3,4‐Disubstituted Pyrazole Analogues as Antitumor CDK Inhibitors.
Authors: Lin Ronghui , Chiu George , Yu Yang , Connolly Peter J. , Li Shengjian , Lu Yanhua , Adams Mary , Fuentes‐Pesquera Angel R. , Emanuel Stuart L. , Greenberger Lee M. 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reaction of 3‐Benzoyl‐1‐methyl‐4‐phenyl‐γ‐piperidol with Arylamines and Arylhydrazines. Synthesis of 3‐Arylamino‐1‐oxo‐1‐phenylpropanes and 1,3‐Diarylpyrazoles and Their Fragmentation under Electron Impact.
Authors: Volkov S. V. , Kutyakov S. V. , Levov A. N. , Polyakova E. I. , Anh Le Tuan , Soldatova S. A. , Terentiev P. B. , Soldatenkov A. T. 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Novel 4(5)‐(5‐Aminotetrahydropyran‐2‐yl)imidazole Derivatives and Their in vivo Release of Neuronal Histamine Measured by Brain Microdialysis.
Authors: Harusawa Shinya , et al. et al. 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Structure of 4‐Arylspirodihydropyranochromen‐2‐one Derivatives.
Authors: Moskvina V. S. , Garazd Ya. L. , Garazd M. M. , Turov A. V. , Khilya V. P. 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Halogenation of Allylthioethers of Pyrazolo[3,4‐d]pyrimidine.
Authors: Onisko M. Yu. , Svalyavin O. V. , Lendel V. G. 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Microwave‐Assisted Reductive Cyclization of N‐Allyl 2‐Nitroanilines: A New Approach to Substituted 1,2,3,4‐Tetrahydroquinoxalines.
Authors: Merisor Elena , Conrad Juergen , Mika Sabine , Beifuss Uwe 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Nucleophilic Cleavage of Selenaheterocyclic Ring in Benzisoselenazol‐3(2H)‐ones and 1,3,2‐Benzodiselenazoles.
Authors: Lisiak R. , Mlochowski J. , Palus J. 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Isolation and Chemical Modification of Clerodane Diterpenoids from Salvia Species as Potential Agonists at the ϰ‐Opioid Receptor.
Authors: Li Yiqiang , Husbands Stephen M. , Mahon Mary F. , Traynor John R. , Rowan Michael G. 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Two New 1‐Oxygenated ent‐Kaurane‐Type Diterpenes from Croton kongensis.
Authors: Chen Wei , Yang Xiao‐Dong , Zhao Jing‐Feng , Zhang Hong‐Bin , Li Liang 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
First Total Synthesis of Antitumor Natural Product (+)‐ and (‐)‐Pericosine A (I): Determination of Absolute Stereo Structure.
Authors: Usami Yoshihide , Takaoka Isao , Ichikawa Hayato , Horibe Yusuke , Tomiyama Syunsuke , Ohtsuka Misako , Imanishi Yumi , Arimoto Masao 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Short and Efficient Total Synthesis of Luotonin A (Ia) and 22‐Hydroxyacuminatine (Ib) Using a Common Cascade Strategy.
Authors: Zhou Hai‐Bin , Liu Guan‐Sai , Yao Zhu‐Jun 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of Neooxazolomycin.
Authors: Onyango Evans Otieno , Tsurumoto Joji , Imai Naoko , Takahashi Keisuke , Ishihara Jun , Hatakeyama Susumi 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Synthesis of Arglabin
Authors: Kalidindi Srinivas , Jeong Won Boo , Schall Andreas , Bandichhor Rakeshwar , Nosse Bernd , Reiser Oliver 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Synthesis of Cytotoxic Anhydrophytosphingosine Pachastrissamine [Jaspine B] (I).
Authors: Prasad Kavirayani R. , Chandrakumar Appayee 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of (‐)‐Tabtoxinine‐β‐lactam, the Phytotoxin of Tobacco Wildfire Disease.
Authors: Kiyota Hiromasa , Takai Takafumi , Shimasaki Yasuharu , Saitoh Masatoshi , Nakayama Osamu , Takada Tomoko , Kuwahara Shigefumi 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cephalimysin A, a Potent Cytotoxic Metabolite from an Aspergillus Species Separated from a Marine Fish.
Authors: Yamada Takeshi , Imai Eiji , Nakatuji Kazuyo , Numata Atsushi , Tanaka Reiko 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Study of the By‐Products of Benzo[f]indolizines Syntheses: A Quest Towards Structural Diversity
Authors: Rigo Benoit , Akue‐Gedu Rufine 
Published: December 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Knallquecksilber
Authors: Bensmann Katja 
Published: December 2007

AbstractDie explosiven Eigenschaften und die Darstellung des Quecksilberfulminats oder auch Knallquecksilbers sind seit mehr als drei Jahrhunderten bekannt. Nun ist es gelungen, die Struktur dieser Verbindung mittels einer Einkristallstrukturanalyse aufzuklären.
Mindfulness‐based stress reduction and attentional control
Authors: Anderson Nicole D. , Lau Mark A. , Segal Zindel V. , Bishop Scott R. 
Published: December 2007

AbstractThis study was designed to test the hypothesis that mindfulness involves sustained attention, attention switching, inhibition of elaborative processing and non‐directed attention. Healthy adults were tested before and after random assignment to an 8‐week Mindfulness‐Based Stress Reduction (MBSR) course (n = 39) or a wait‐list control (n = 33). Testing included measures of sustained attention, attention switching, Stroop interference (as a measure of inhibition of elaborative processing), detection of objects in consistent or inconsistent scenes (as a measure of non‐directed attention), as well as self‐report measures of emotional well‐being and mindfulness. Participation in the MBSR course was associated with significantly greater improvements in emotional well‐being and mindfulness, but no improvements in attentional control relative to the control group. However, improvements in mindfulness after MBSR were correlated with improvements in object detection. We discuss the implications of these results as they relate to the role of attention in mindfulness. Copyright © 2007 John Wiley & Sons, Ltd.
The Y‐OQ‐12: psychosocial screening of youth in primary care medicine using items from an outcome measure
Authors: Tzoumas Anthony C. , Tzoumas Jennifer L. , Burlingame Gary M. , Nelson Philip L. , Wells M. Gawain , Gray Douglas D. 
Published: December 2007

AbstractThe studies reported herein describe the successful development and validation of a youth mental health screening instrument for identifying psychosocial distress in pediatric care patients. As a subset of 12 items from the well‐established Youth Outcome Questionnaire‐2.01 (Y‐OQ‐2.01), the Youth Outcome Questionnaire‐12 (Y‐OQ‐12) screen intends to be the first stage in a two‐stage screening process. Patients screened as positive complete the full‐length Y‐OQ‐2.01 in the second stage. A stage two score in the clinical range can serve as a baseline in continuous outcome tracking using the Y‐OQ‐2.01. The 12 parent‐report items of the Y‐OQ‐12 were selected using a combination of items from the Y‐OQ‐2.01 using a known‐groups approach based on community (n = 500) and outpatient psychiatric (n = 500) samples. The sensitivity of the Y‐OQ‐12 was 0.84, with a specificity of 0.82 and an internal consistency of 0.90. Two factors emerged, accounting for 48% and 9% of the variance (‘mood/behavioural symptom distress’ and ‘quality of life’, respectively). A second validation study involving 371 youth from pediatric settings in three US states compared the Y‐OQ‐12 with the Pediatric Symptom Checklist (PSC) and the Diagnostic Interview Schedule for Children‐Present State. The Y‐OQ‐12 demonstrated sensitivity, specificity and predictive power that were comparable to the PSC and shows promise for screening in routine practice. The authors encourage the use of the Y‐OQ‐12 in practice and await the replication of these findings in future research. Copyright © 2007 John Wiley & Sons, Ltd.
Multiparametric analysis of normal and postchemotherapy bone marrow: Implication for the detection of leukemia‐associated immunophenotypes
Authors: Olaru D. , Campos L. , Flandrin P. , Nadal N. , Duval A. , Chautard S. , Guyotat D. 
Published: December 2007

AbstractBackground:The knowledge of normal marrow is mandatory to assess the malignant counterpart of normal cells and define leukemia‐associated immunophenotypes (LAIPs). In this study, the expression of a variety of antigens expressed in normal and postchemotherapy bone marrow (BM) was analyzed to provide a frame of reference for the identification of myeloid LAIPs.Methods:Multiparameter four‐ and six‐color flow cytometry was used to define antigen combinations totally absent or present at very minimal levels in marrow cells of normal individuals (n = 20) and patients receiving chemotherapy for acute lymphoblastic leukemia (n = 20). Immature (blast) cells were gated according to CD45/SSC properties. Fifty‐three acute myeloid leukemia (AML) samples were studied in six‐color combinations.Results:In six‐color flow cytometry, 47 phenotypes were totally absent from blast gate in all normal samples. Forty‐one other phenotypes were identified in less than 0.05% of blast cells. There was no difference between normal and postchemotherapy BMs. The four‐color panel allowed to identify only 30 phenotypes present at a frequency <0.05%. Using the six‐color panel, 58% of the absent or infrequent phenotypes in normal BM were found in at least one of 53 AML samples. All AML cases exhibited at least one LAIP.Conclusion:Our results show that the ability to distinguish leukemic from healthy cells is considerably increased by a six‐color approach. Furthermore, these absent or infrequent phenotypes in normal BM are identified in AML and can be utilized for minimal residual disease study. © 2007 Clinical Cytometry Society
Unusual direct phycoerythrin labeling of B‐cells from a splenic marginal zone lymphoma
Authors: Tabary T. , Staal‐Viliare A. , Rault J. P. , Didion J. , Latger‐Cannard V. , Reveil B. , Cohen J. H. M. , Rio Y. 
Published: December 2007

AbstractFlow cytometry is the most widely used method for lymphocyte subset characterization. Two types of antibodies, directly labeled with fluorochrome, are currently used for immunological diagnosis of B‐cell lymphoproliferation: monoclonal antibodies against leukocyte differentiation antigens and polyclonal antibodies against immunoglobulins and light chains. In this study is described the case of a patient with an uncommon immunophenotyping of a B‐cell lymphoproliferative disorder. B‐cells from peripheral blood and from bone marrow reacted positively with all the tested phycoerythrin (PE)‐conjugated antibodies, including the isotypic control. So we thought about a B‐cell proliferation carrying a surface receptor recognizing PE: these B‐cells were directly labeled with streptavidin‐PE, indeed. Moreover, the immunodots from the patient were able to fix the streptavidin‐PE. Finally, this unusual immunophenotyping was solved by using antibodies labeled with other fluorochromes than PE. © 2007 Clinical Cytometry Society.
CD158k/KIR3DL2 is a useful marker for identifying neoplastic T‐cells in Sézary syndrome by flow cytometry
Authors: Bahler David W. , Hartung Leah , Hill Sally , Bowen Glen M. , Vonderheid Eric C. 
Published: December 2007

AbstractEnumeration of neoplastic T‐cells in peripheral blood specimens is necessary for the diagnosis of Sézary syndrome (SS) and monitoring treatment responses. Because neoplastic T‐cells in SS can be difficult to identify by morphology alone, flow cytometry immunophenotyping is often utilized. However, the reported immunophenotypic criteria for identifying neoplastic T‐cells in SS are variable, not present in all cases, or sometimes found in reactive T‐cell populations. Peripheral blood lymphocytes from 33 cases of SS were evaluated for the expression of pan‐T cell antigens and killer cell immunoglobulin‐like MHC receptors (KIR) CD158a, CD158b, CD158e, CD158i, and CD158k by multiparameter flow cytometry using monoclonal antibodies EB6, GL183, FES172, Z27, and Q66. A variety of abnormalities related to expression of pan‐T‐cell antigens typical of neoplastic T‐cells were observed. Expression of CD158k was observed in 32/33 cases and restricted to the phenotypically abnormal T‐cell populations, while expression of other KIR was mostly negative. Our findings confirm and extend recent reports by one group that CD158k is expressed by most SS cases. Moreover, our observation that CD4 positive, CD7 negative T‐cells are mostly CD158k negative further suggests that CD158k may be able to help identify and enumerate neoplastic T‐cells in SS even when present at low levels.
Endoscopic ultrasound‐guided fine needle aspiration is useful for nodal staging in patients with pleural mesothelioma
Authors: Bean Sarah M. , Eloubeidi Mohamad A. , Cerfolio Robert , Chhieng David C. , Eltoum Isam A. 
Published: December 2007

AbstractPatients with malignant pleural mesothelioma and negative N2 stage lymph nodes may benefit from extrapleural pneumonectomy with adjuvant therapy. The objective of this study is to describe the use of EUS‐FNA to determine N2 stage status in patients with mesothelioma and its impact in the management of such patients. Six patients (mean age, 62 yr; median age, 63 yr; range, 52–70 yr; 5 men; 1 woman) underwent EUS‐FNA for staging of N2 lymph nodes from July 2000 to July 2006. Follow‐up included operative notes, treatment summaries, and surgical pathology. Eight sites were aspirated: four subcarinal lymph nodes, three aorto‐pulmonary window lymph nodes, and one paraesophageal mass. Two of 8 (25%) aspirates were positive for metastatic disease in two different patients. Two false negative EUS‐FNAs were observed and were attributed to sampling error not diagnostic error. No complications were observed. EUS‐FNA is a safe N2 node staging technique in patients with mesothelioma. A positive N2 lymph node by EUS‐FNA may be a contraindication to definitive surgery in patients with malignant mesothelioma. Diagn. Cytopathol. 2008;36:32–37. © 2007 Wiley‐Liss, Inc.
Nephrogenic adenoma identified on urine cytology using PAX‐2 immunostaining
Authors: Herlitz Leal C. , Tong Guo‐Xia , Hamele‐Bena Diane , Greenebaum Ellen 
Published: December 2007

AbstractUrine cytology is a sensitive and specific method in detecting urothelial carcinoma of the urinary bladder, particularly the high‐grade ones. However, the cytologic features of nonneoplastic lesions of the lower urinary tract, including nephrogenic adenoma, are nonspecific and may cause false positive diagnosis. Recent evidence has demonstrated that nephrogenic adenoma is a true “nephrogenic” lesion derived from the exfoliated and implanted renal tubular cells in the urinary tract. This has promoted the use of immunostaining of renal transcription factor PAX2 in tissue biopsies to differentiate nephrogenic adenoma from the common malignant tumors of the lower urinary tract. We report here that PAX2 immunostaining can also be used in urine cytology specimen to identify nephrogenic adenoma. Combination of PAX2 immunostaining and cytologic analysis may increase the accuracy in identifying this benign lesion in urine cytology specimen and therefore reduce unnecessary repeat cystoscopy and biopsy procedures. This may be a cost effective follow‐ up method for patients with an established diagnosis of nephrogenic adenoma. Diagn. Cytopathol. 2008;36:47–49. © 2007 Wiley‐Liss, Inc.
Influence of the Copper Coordination Geometry on the DNA Cleavage Activity of Clip‐Phen Complexes Studied by DFT
Authors: de Hoog Paul , Louwerse Manuel J. , Gamez Patrick , Pitié Marguerite , Baerends Evert Jan , Meunier Bernard , Reedijk Jan 
Published: December 2007

AbstractSix different Cu(Clip‐Phen)2+/+ complexes, with or without a coordinating chloride ligand, have been investigated by DFT calculations to evaluate the influence of the length and functional substituents of the bridge linking the two phenanthroline units on the DNA cleavage activity. The changes of the structural and energetic profiles imposed by the bridge of these complexes have been analyzed by comparison with the well studied nuclease active agent Cu(phen)22+/+. The present studies show that the bridge length of these complexes is critical for the consequent geometry, and both the strain and ligand binding energies. Upon reduction (needed for the DNA cleavage activity), the geometry of Cu(phen)2 changes drastically. The behavior of the complexes with a 4‐ or 5‐carbon bridge resembles the behavior of Cu(phen)22+/+. However, the geometries of the complexes with two‐ or three‐carbon bridges are markedly different from the one of unbridged Cu(phen)2+, as a result of constraints enforced by the short bridge. The results suggest that the cleaving activities of these bis‐phenanthroline complexes are influenced by the different ligand environment geometries imposed by the bridge, and not by the change of the redox properties. It appears that the influence of the different bridges on the redox properties of the complexes is minor.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
A polymerase chain reaction‐restriction fragment length polymorphism method based on the analysis of a 16S rRNA/tRNAVal mitochondrial region for species identification of commercial penaeid shrimps (Crustacea: Decapoda: Penaeoidea) of food interest
Authors: Pascoal Ananías , Barros‐Velázquez Jorge , Cepeda Alberto , Gallardo José M. , Calo‐Mata Pilar 
Published: December 2007

AbstractA simple PCR‐RFLP method has been developed for the identification of 19 penaeid shrimp species of food interest belonging to the superfamily Penaeoidea. Preliminary amplification, sequencing and alignment of a 960 bp fragment of the 16S rRNA/tRNAVal/12S rRNA mitochondrial region allowed the design of 16Scru4/16Scru4 primers, constructed on well‐conserved mitochondrial sequences of the penaeid shrimp species considered. Such primers afforded the amplification of an internal 515–535 bp region of the 16S rRNA/tRNAVal genes that, when subjected to cleavage with AluI, TaqI and HinfI, provided species‐specific restriction patterns. Moreover, the proposed method also allowed the definition of different intraspecific restriction types between different populations of Litopenaeus vannamei, Farfantepenaeus notialis, Fenneropenaeus merguiensis, Metapenaeus sp., Melicertus latisulcatus and Pleoticus muelleri of different origins. The method described here was also successfully applied for the identification of penaeid shrimps in complex processed precooked foods, where this type of shellfish is used as an added‐value food ingredient. Sequencing analysis provided new information about the genetic relationships among shrimps not only at the levels of species and genus, but also among different populations at intraspecific level. The 16S rRNA/tRNAVal fragment considered in this study seems to be accurate for shrimp species identification in raw and processed foodstuffs and for phylogenetic analysis among penaeid shrimp species.
SOS1 mutations are rare in human malignancies: Implications for Noonan syndrome patients
Authors: Swanson Kenneth D. , Winter Jordan M. , Reis Marcelo , Bentires‐Alj Mohamed , Greulich Heidi , Grewal Rupinder , Hruban Ralph H. , Yeo Charles J. , Yassin Yosuf , Iartchouk Oleg , Montgomery Kate , Whitman Susan P. , Caligiuri Michael A. , Loh Mignon L. , Gilliland D. Gary , Look A. Thomas , Kucherlapati Raju , Kern Scott E. , Meyerson Matthew , Neel Benjamin G. 
Published: December 2007

AbstractGerm line gain‐of‐function mutations in several members of the RAS/ERK pathway, including PTPN11, KRAS, and RAF1, cause the autosomal dominant genetic disorder Noonan Syndrome (NS). NS patients are at increased risk of leukemia/myeloproliferative disease and possibly some solid tumors, such as neuroblastoma. Recently, SOS1 gain of function mutations have also been shown to cause NS. Somatic PTPN11, KRAS, and RAF1 mutations occur (although at different frequencies) in a variety of sporadic neoplasms, but whether SOS1 mutations are associated with human cancer has not been evaluated. We sequenced DNA from a total of 810 primary malignancies, including pancreatic, lung, breast, and colon carcinomas, and acute myelogenous leukemia, as well as several neuroblastoma cell lines. From this large, diverse series, missense SOS1 mutations were identified in a single pancreatic tumor, one lung adenocarcinoma, and a T‐cell acute lymphoblastic leukemia cell line. Our findings suggest that SOS1 is not a significant human oncogene in most cancers. Furthermore, NS patients with SOS1 mutations may not be at increased risk of developing cancer. © 2007 Wiley‐Liss, Inc.