bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social problem‐solving in intimate partner violence victims: Exploring the relative contributions of shame and PTSD symptoms
Authors: Beck J. Gayle , Griffith Elizabeth L. , Majeed Rimsha , Beyer Melissa S. , Bowen Mya E. , Free Bre'Anna L. 
Published: March 2024

AbstractObjectiveThis study examined the contributions of shame and posttraumatic stress disorder (PTSD) symptoms to two dimensions of social problem‐solving.MethodA sample of 426 women who were seeking mental health assistance following experiences of intimate partner violence completed self‐report and clinician measures. Separate path analyses were conducted for problem orientation and problem‐solving styles.ResultsIn the model examining problem orientation, higher levels of shame were significantly associated with lower levels of positive problem orientation (f2 = 0.32) and higher levels of negative problem orientation (f2 = 0.92), with large effects noted. PTSD symptoms were significantly, positively associated with negative problem orientation (f2 = 0.3, large effect). When examining problem‐solving styles, shame showed a significant negative association with rational style (f2 = 0.08, small effect) and significant positive associations with impulsive style (f2 = 0.45, large effect) and avoidant style (f2 = 0.48, large effect). PTSD symptoms did not return significant associations with any of the three problem‐solving styles.ConclusionResults indicate that shame holds notable associations with both dimensions of social problem‐solving, relative to PTSD symptoms, and are discussed in light of current models of post‐trauma functioning. Implications for clinical care and early intervention efforts are highlighted.
Anterolateral augmentation procedures during anterior cruciate ligament reconstructions in skeletally immature patients: Scoping review of surgical techniques and outcomes
Authors: Dietvorst Martijn , Verhagen Stéphanie , van der Steen Marieke C. , van Douveren Florens Q. M. P. , Janssen Rob P. A. 
Published: March 2024

AbstractPurposeGraft failure rates after anterior cruciate ligament reconstruction (ACLR) in children and adolescents are higher compared to adults. Anterolateral augmentation procedures have recently generated increased focus regarding their ability to reduce graft failure rates. Concerns in skeletally immatures are potential growth disturbances and overconstraint after anterolateral augmentation. The aim of this scoping review is to provide an overview of all current anterolateral augmentation procedures in skeletally immature patients and to discuss surgical techniques, clinical and biomechanical outcomes.MethodsThis scoping review was performed following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analysis) statement extension for scoping reviews. On 22 December 2022, an information specialist performed a systematic literature search in Cochrane, PubMed (Medline) and EMBASE databases. Inclusion criteria were anterolateral augmentation procedures, including lateral extra‐articular tenodesis (LET) and anterolateral ligament reconstruction (ALLR), in combination with ACLR in skeletally immatures.ResultsTwenty studies were included after screening 1.485 abstracts. Seventeen studies describe LET techniques, four studies ALLR techniques and one study both techniques. Biomechanical data is scarce and shows conflicting results. Two studies compared ACLR with LET to ACLR in skeletally immatures with promising results in favour of the combined procedure. There were no differences in outcomes between LET and ALLR.ConclusionsSeveral LET and ALLR techniques have been described for skeletally immature patients and the first clinical data on LET and ALLR is available, which showed promising results. Further research is necessary to evaluate the risk of growth disturbances and overconstraint in skeletally immatures.Level of EvidenceLevel IV.
Integrating density functional theory and chemical ionization mass spectrometry techniques to assess benzophenone derivatives in food packaging: implications for enhancing food quality and safety
Authors: Bhatia Manjeet 
Published: March 2024

AbstractBenzophenone and related derivatives are widely used as photoinitiators for food packaging to cure inks or lacquers with ultraviolet (UV) light on cardboard and paper. However, there are concerns about the potential health risks of their migration into food. Knowing the physical and chemical properties of benzophenone and its derivatives could play a significant role in their quantification and analysis using chemical ionization mass spectrometry (CI‐MS) methods. These parameters are evaluated using B3LYP/6‐311++** density functional theory (DFT) implemented on Gaussian code. Ion–molecule chemistry through the selection of reagent ions, reaction energetics and kinetics, thermodynamic stability, and reactivity of molecules deemed to foster VOC identification and quantification via CI‐MS techniques. The VOCs under study are expected to undergo exothermic reactions from H3O+, NH4+, NO+, and O2+ ions, except endothermic proton transfer from NH4+ to 2‐hydroxy‐4‐methoxybenzophenone and 2,3,4‐trihydroxy benzophenone. These compounds possess less proton affinities than NH3 and are least stable in their protonated forms. The DFT computed properties provide the basis for developing reliable and accurate methods to detect and measure the presence of benzophenone and its derivatives in packaging materials and food products.
Identification and genetic characterization of a recently identified enterovirus C116 in China
Authors: Han Zhen‐Zhi , Li Ji‐Chen , Xiao Jin‐Bo , Hong Mei , Lu Huan‐Huan , Song Yang , Liu Ying , Wang Rui , Fu Han‐Haoyu , Wang Fang‐Ming , Zhu Shuang‐Li , Yan Dong‐Mei , Ji Tian‐Jiao , Zhao Lin‐Qing , Zhang Yong 
Published: March 2024

AbstractEnterovirus C116 (EV‐C116) is a new member of the enterovirus C group which is closely associated with several infectious diseases. Although sporadic studies have detected EV‐C116 in clinical samples worldwide, there is currently limited information available. In this study, two EV‐C‐positive fecal specimens were detected in apparently healthy children, which harbored low abundance, through meta‐transcriptome sequencing. Based on the prototypes of several EV‐Cs, two lineages were observed. Lineage 1 included many types that could not cause EV‐like cytopathic effect in cell culture. Three genogroups of EV‐C116 were divided in the maximum likelihood tree, and the two strains in this study (XZ2 and XZ113) formed two different lineages, suggesting that EV‐C116 still diffuses worldwide. Obvious inter‐type recombination events were observed in the XZ2 strain, with CVA22 identified as a minor donor. However, another strain (XZ113) underwent different recombination situations, highlighting the importance of recombination in the formation of EV‐Cs biodiversity. The EV‐C116 strains could propagate in rhabdomyosarcoma cell cultures at low titer; however, EV‐like cytopathic effects were not observed. HEp‐2, L20B, VERO, and 293T cell lines did not provide an appropriate environment for EV‐C116 growth. These results challenge the traditional recognition of the uncultured nature of EV‐C116 strains and explain the difficulty of clinical detection.
Investigating the Upper Holocene palaeoenvironment and human subsistence strategy in the Khor Rori coastal area by studying mollusc remains from the Inqitat plateau (Dhofar, Sultanate of Oman)
Authors: Crippa Gaia , Lischi Silvia , Cremaschi Mauro 
Published: March 2024

ABSTRACTArchaeological shells have a great potential for reconstructing past environments and human–environment interactions. The Inqitat plateau (Khor Rori Archaeological Park, Oman) shows rich mollusc assemblages, present in the HAS1 settlement and in a shell midden nearby (Iron Age). By analysing the environmental requirements of the species identified in the assemblages, we reconstruct the past coastal environment and investigate its exploitation by the local population and human activities during the settlement occupation. This is the first multidisciplinary investigation of Iron Age molluscs from Dhofar. Our results indicate that the environment surrounding the site was characterised by rocky shores and shallow‐water sandy to sandy‐muddy substrates, where locals collected shells. Mangrove species were recovered in few numbers, indicating that this environment was restricted or not exploited. Furthermore, a different use of shells between circular houses within the settlement and the midden was observed; in the former, species used as ornaments are more abundant, whereas, in the latter, species used for food purposes are found, confirming the primary use of the midden as a dump. The presence of easily accessible settings for mollusc collection in the site's vicinity and the richness in food resources due to a coastal upwelling makes this region very attractive for human populations.
Nonlinear Dynamics of Higher‐Order Quasi‐Phase‐Matched Dispersive Waves Formation in Dispersion‐Oscillating Liquid‐Core Fibers
Authors: Qi Xue , Lühder Tilman A. K. , Scheibinger Ramona , Eschrich Tina , Chemnitz Mario , Schmidt Markus A. 
Published: March 2024

AbstractHere, the concept of generating higher‐order dispersive waves (DWs) via quasi‐phase‐matching (QPM) in periodically dispersion‐modulated liquid‐core fibers are demonstrated by generating distinct narrowband sidebands generated outside the conventional supercontinuum (SC) spectrum. Through controlled partial core collapse, the commonly used phase‐matching (PM) condition is amended by an additional grating‐related term. This results in the generation of ultrashort higher‐order DWs controlled by the grating parameters, extending the conventional SC spectrum up to 3 . Of particular interest is the excellent overlap of the QPM‐peaks obtained from experiments, simulations, and PM considerations, showing the quality of the implementation approach and allowing for controlled narrowband peaks generation even for femtosecond input pulses. In summary, this multicolor generation concept embodies a versatile photonic platform with unique dispersion control capabilities for the transfer of spectral power into selected narrowband spectral intervals. It stands out with its unique capabilities, making it well‐suited for applications in diverse fields like bioanalytics, life sciences, quantum technology, and metrology.
High Dose Progesterone Loaded PCL‐Polysorbate 80 Transdermal Fibers for Potential Application in Gynecological Oncology
Authors: Shafi Omar , Phadnis Saurabh , Chan Un Hou , Edirisinghe Mohan , Brako Francis 
Published: March 2024

AbstractProgesterone (P4), commonly administered in high doses for endometrial cancer palliative management, has limitations in current delivery systems. This preliminary in vitro drug release study introduces electrospun patches to offer a new perspective on P4 delivery. The study aimed to assess the influence of the surfactant polysorbate 80 (PS80) on the release of P4 from polycaprolactone (PCL) fibers. The PS80 effects are examined to inform the fine‐tuning of the fibre generation process. Patches developed, PCL wet (with PS80) and PCL dry (without PS80), showed encapsulation efficiencies of 76% and 42%, respectively. The dose levels studied are 6.1 mg for PCL wet and 4.4 mg for PCL dry samples. Molecular studies show that higher surfactant levels improved P4‐polymer mixing, enhancing dissolution and release rates. Patches with PS80 released 66% of the drug in 17 h, while those without released only 51%. Release data best fit the Weibull model, showcasing promise for these patches in transdermal P4 delivery. This study offers a non‐invasive option compared to traditional methods and underscores the need for further research to confirm the patches' clinical effectiveness for potential use in gynecological oncology.
Tailoring Nanostructured Cellulose for Efficient Pickering Emulsions Stabilization
Authors: Pirozzi Annachiara , Bettotti Paolo , Facchinelli Tiziano , D'Amato Elvira , Scarpa Marina , Donsì Francesco 
Published: March 2024

AbstractNanostructured celluloses, nanofibrils (CNFs) and nanocrystals (CNCs), are prepared through TEMPO‐mediated oxidation by controlling the intensity of the process modulated by catalyst concentration and processing time. These nanomaterials are evaluated as stabilizers for Pickering emulsions, fabricated using high‐pressure homogenization (HPH). Both CNFs and CNCs exhibit efficient steric and electrostatic stabilization of oil‐in‐water (O/W) emulsions. CNFs display strong inter‐droplet interactions, leading to the formation of a 3D fibrous network emulsion with higher viscosity compared to CNCs‐stabilized emulsions. However, CNFs also show a higher tendency toward flocculation, due to fibrils’ entanglement in the continuous phase. Interestingly, the HPH treatment has a notable impact on the CNFs’ interfacial layer, enhancing the emulsifying ability of CNFs and improving stability against coalescence. Conversely, CNCs‐stabilized emulsions exhibit lower viscosity but demonstrate higher interfacial activity and stabilization capability. Remarkably, no phase separation during 10 months of refrigerated storage, indicating excellent long‐term stability. Importantly, the HPH treatment does not significantly change the emulsifying ability of CNCs. In conclusion, this study highlights the possibility of obtaining nanocelluloses (NCs) with tailored emulsifying properties by regulating the intensity of TEMPO‐mediated oxidation applied to pulp cellulose. These findings open up new opportunities for the development of innovative ingredients for the food and cosmetic industries.
Computational investigation of high Curie temperature in a new N‐type ferromagnetic diluted magnetic semiconductors, especially iron‐doped on GaSb
Authors: Mekuye Bawoke , Atnafu Dagne , Yibeltal Ayenew , Abera Mesfin 
Published: March 2024

AbstractDiluted magnetic semiconductors have become a research area in the past few years due to the importance of new technology, spintronics devices, and green technology to withstand rising global temperatures. Both n‐type and p‐type diluted magnetic semiconductors are used in pairs for perfect performance, especially for p‐n junction diodes, the p‐d Zener model, GMR, and TMR spintronics devices. The main challenge for some researchers is to find a ferromagnetic diluted magnetic semiconductor with a Curie temperature greater than room temperature for both n‐type and p‐type ferromagnetic diluted semiconductors, but this study has solved this problem. In the present study, the ferromagnetic properties of an n‐type gallium iron antimonide diluted semiconductor have been studied using the Hamiltonian model without applying an external magnetic field, electric field, or chemical potential. We have formulated a Hamiltonian model in the system, considering the application of the green formalism function and the transformation of Holstein–Primakaff. The Curie temperature, dispersion, number of magnons, reduced magnetization, and specific heat capacity of ferromagnetic magnons of the n‐type (Ga, Fe)Sb formula are formulated. The Curie temperature versus concentration graph is plotted, and the specific heat capacity and magnetization versus temperature graphs are plotted. In this study, a surprising situation is that the Curie temperature of n‐type diluted magnetic semiconductor is investigated above room temperature, which is 330.4 K. The ferromagnetic properties of appear up to 330.4 K, which is able to play a major role in spintronic and next‐generation green nanotechnology devices.
Assessment of continuous laser ablation model for lightweight quartz fiber reinforced phenolic composite
Authors: Yan Xiaojie , Jin Xiangyu , Pan Yiwu , Wang Hebing , Fan Zhaolin , Hong Changqing , Zhang Xinghong 
Published: March 2024

AbstractA comprehensive investigation into the interaction between a continuous wave (CW) laser and lightweight quartz fiber reinforced phenolic (LQFRP) composite would provide valuable insights into the characteristics and performance of ablation. To simulate the CW laser ablation of LQFRP composite, a 2D symmetrical element model was developed, incorporating the heat conduction equation, resin pyrolysis mechanism, and deformed geometry module. This model was the first to examine the internal pyrolysis degree and gas flow field of LQFRP composite under CW laser irradiation, and its predictions were in reasonable agreement with experimental measurements. Additionally, the model was used to simulate CW laser ablation with varying spot sizes and power densities. The results revealed that during the laser ablation process, an internal high‐pressure zone formed on the side of the ablation hole. The volatilization of SiO2 was identified as the dominant dissipation mechanism for material removal. The width of the ablation hole was positively correlated with the laser spot size, while the depth of the ablation hole was positively correlated with the laser power density.Highlights
The model first studied the internal pyrolysis degree and flow field of LQFRP composite under laser irradiation.
The volatilization of SiO2 was identified as the dominant dissipation mechanism for material removal.
An internal high‐pressure zone formed on the side of the ablation hole during the laser ablation process.
The width of the ablation hole was positively correlated with the laser spot size, while the depth of the ablation hole was positively correlated with the laser power density.
Anti‐LGI1 encephalitis preceded by psychiatric symptoms: A case report
Authors: Numazawa Takuma , Kobayashi Ryota , Shirata Toshinori , Kondo Toshiyuki , Sato Hiroyasu , Tanaka Keiko , Suzuki Akihito 
Published: March 2024

AbstractBackgroundTo date, only a few reports of anti‐LGI1 encephalitis with isolated psychiatric symptoms in the initial phase have been reported. We present a relatively rare case of antileucine‐rich glioma‐inactivated 1 (LGI1) encephalitis that developed only psychiatric symptoms at the onset.Case PresentationThe patient was a male in his 40s who developed anxiety and panic symptoms and was started on antidepressants after being diagnosed with panic disorder by a psychiatrist. He visited our hospital 2 months later presenting with hallucinations, delusions, mild cognitive decline, and faciobrachial dystonic seizures in the left upper extremity and face. Fluid‐attenuated inversion recovery magnetic resonance imaging revealed swelling and hyperintensities in the right caudate nucleus and putamen. Cerebrospinal fluid analysis did not show increased protein levels or cell counts and revealed positive oligoclonal bands. Subsequently, positive results for anti‐LGI1 antibodies were observed in the cerebrospinal fluid. Therefore, the patient was diagnosed with anti‐LGI1 encephalitis.ConclusionThis case highlights the need to consider anti‐LGI1 encephalitis therapy in patients with acute‐onset psychiatric symptoms.
Self‐healing waterborne fluorinated polyurethane‐acrylate based on photoreversible reaction and hydrogen bonds
Authors: Liu Xiuqing , Zhou Jianhua , Li Hong 
Published: March 2024

AbstractThe development of self‐healing materials is an effective strategy to improve the service life of polymer materials. In this study, self‐healing waterborne fluorinated polyurethane‐acrylate (WFPUA) containing UV‐responsive coumarin groups was prepared by Pickering emulsion polymerization using modified cellulose nanocrystal as a stabilizer. The effect of double bond‐terminated waterborne polyurethane content on emulsion polymerization and latex film properties was mainly studied. Due to the dynamic reversibility of the coumarin groups and the synergistic effect of hydrogen bonds, the optimized sample (WFPUA‐30) had excellent mechanical properties and self‐healing properties. The tensile strength was 5.24 MPa and the elongation at break was 267%. The self‐healing efficiency of tensile strength and elongation at break after 6 h of repair was 86.52% and 93.20%, respectively. In addition, due to the presence of fluorine‐containing groups, the water and oil contact angles of the latex film could reach 101.7° and 82.1°, respectively. This work broadens the way for the manufacture of self‐healing and multifunctional waterborne polyurethane‐acrylates. © 2024 Society of Industrial Chemistry.
A novel micropeptide, Slitharin, exerts cardioprotective effects in myocardial infarction
Authors: Ibrahim Ahmed G. E. , Ciullo Alessandra , Yamaguchi Shukuro , Li Chang , Antes Travis , Jones Xaviar , Li Liang , Murali Ramachandran , Maslennikov Innokentiy , Sundararaman Niveda , Soetkamp Daniel , Cingolani Eugenio , Van Eyk Jennifer , Marbán Eduardo 
Published: March 2024

AbstractPurpose: Micropeptides are an emerging class of proteins that play critical roles in cell signaling. Here, we describe the discovery of a novel micropeptide, dubbed slitharin (Slt), in conditioned media from Cardiosphere‐derived cells (CDCs), a therapeutic cardiac stromal cell type.Experimental design: We performed mass spectrometry of peptide‐enriched fractions from the conditioned media of CDCs and a therapeutically inert cell type (human dermal fibrobasts). We then evaluated the therapeutic capacity of the candidate peptide using an in vitro model of cardiomyocyte injury and a rat model of myocardial infarction.Results: We identified a novel 24‐amino acid micropeptide (dubbed Slitharin [Slt]) with a non‐canonical leucine start codon, arising from long intergenic non‐coding (LINC) RNA 2099. Neonatal rat ventricular myocytes (NRVMs) exposed to Slt were protected from hypoxic injury in vitro compared to a vehicle or scrambled control. Transcriptomic analysis of cardiomyocytes exposed to Slt reveals cytoprotective capacity, putatively through regulation of stress‐induced MAPK‐ERK. Slt also exerted cardioprotective effects in rats with myocardial infarction as shown by reduced infarct size 48 h post‐injury.Conclusions and clinical relavance: Thus, Slt is a non‐coding RNA‐derived micropeptide, identified in the extracellular space, with a potential cardioprotective function.
The myeloperoxidase inhibitor mitiperstat (AZD4831) does not prolong the QT interval at expected therapeutic doses
Authors: Parkinson Joanna , Sundell Jesper , Rekić Dinko , Nelander Karin , Ericsson Hans , Ebrahimi Ahmad , Dota Corina , Sunnåker Mikael 
Published: March 2024

AbstractMitiperstat is a myeloperoxidase inhibitor in clinical development for treatment of patients with heart failure and preserved or mildly reduced ejection fraction, non‐alcoholic steatohepatits and chronic obstructive pulmonary disease. We aimed to assess the risk of QT‐interval prolongation with mitiperstat using concentration–QT (C‐QT) modeling. Healthy male volunteers were randomized to receive single oral doses of mitiperstat 5, 15, 45, 135, or 405 mg (n = 6 per dose) or matching placebo (n = 10) in a phase 1 study (NCT02712372). Time‐matched pharmacokinetic and digital electrocardiogram data were collected at the baseline (pre‐dose) and at 11 time‐points up to 48 h post‐dose. C‐QT analysis was prespecified as an exploratory objective. The prespecified linear mixed effects model used baseline‐adjusted QT interval corrected for the heart rate by Fridericia's formula (ΔQTcF) as a dependent variable and plasma mitiperstat concentration as an independent variable. Initial exploratory analyses indicated that all model assumptions were met (no effect on heart rate; appropriate use of QTcF; no hysteresis; linear concentration–response relationship). Model‐predicted mean baseline‐corrected and placebo‐adjusted ΔΔQTcF was +0.73 ms (90% confidence interval [CI]: −1.73, +3.19) at the highest anticipated clinical exposure (0.093 μmol/L) during treatment with mitiperstat 5 mg once daily. The upper 90% CI was below the established threshold of regulatory concern. The 16‐fold margin to the highest observed exposure was high enough to mean that a positive control was not needed. Mitiperstat is not associated with risk of QT‐interval prolongation at expected therapeutic concentrations.