bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rates and correlates of employment in people with schizophrenia in the UK, France and Germany
Authors: Marwaha Steven , Johnson Sonia , Bebbington Paul , Stafford Mai , Angermeyer Matthias C. , Brugha Traolach , Azorin Jean-Michel , Kilian Reinhold , Hansen Karina , Toumi Mondher 
Published: June 2007

BackgroundLittle is known about international variations in employment rates among people with schizophrenia or about the factors associated with employment in this disorder.AimsTo describe employment patterns and the variables associated with working in an international sample of people with schizophrenia.MethodAn analysis was made of baseline data from the European Schizophrenia Cohort study, a 2-year investigation of people with schizophrenia in contact with secondary services and living in France, Germany and the UK (n = 1208).ResultsParticipants were working in all sections of the job market. People who had a degree, were living with their families or had experienced only a single episode of illness were more likely to be working. A continuous illness course, more severe non-psychotic symptoms and drug misuse reduced the odds of employment. There were large variations between centres in employment rates, which were highest in the three German study sites. These differences persisted after adjustment for individual characteristics.ConclusionsLocal social contexts may be as important as individual or illness-related factors in explaining employment status.
Determining when impairment constitutes incapacity for informed consent in schizophrenia research
Authors: Kim Scott Y. H. , Appelbaum Paul S. , Swan Jeffrey , Stroup T. Scott , McEvoy Joseph P. , Goff Donald C. , Jeste Dilip V. , Lamberti J. Steven , Leibovici Adrian , Caine Eric D. 
Published: June 2007

BackgroundAlthough people with schizophrenia display impaired abilities for consent, it is not known how much impairment constitutes incapacity.AimsTo assess a method for determining the categorical capacity status of potential participants in schizophrenia research.MethodExpert-judgement validation of capacity thresholds on the sub-scales of the MacArthur Competence Assessment Tool – Clinical Research (MacCAT–CR) was evaluated using receiver operating characteristic (ROC) analysis in 91 people with severe mental illness and 40 controls.ResultsThe ROC areas under the curve for the understanding, appreciation and reasoning sub-scales of the MacCAT–CR were 0.94 (95% CI 0.88–0.99), 0.85 (95% CI 0.76–0.94) and 0.80 (95% CI 0.70–0.90). These findings yielded negative and positive predictive values of incapacity that can guide the practice of investigators and research ethics committees.ConclusionsBy performing such validation studies for a few categories of research with varying risks and benefits, it might be possible to create evidence-based capacity determination guidelines for most schizophrenia research.
Consultant psychiatrists' working patterns
Authors: Mears Alex , Pajak Sarah , Kendall Tim , Katona Cornelius , Medina Jibby , Huxley Peter , Evans Sherrill , Gately Claire 
Published: June 2007

Aims and MethodTo explore relationships between different styles of working and measures of occupational pressure in consultant psychiatrists. A random sample of 500 consultant psychiatrists were sent a questionnaire about working patterns and lifestyle factors, with other sections using validated tools (such as the 12-item General Health Questionnaire; GHQ).ResultsThere were 185 useable questionnaires returned (an adjusted response rate of 39%). Significant relationships were identified between job content and GHQ and burnout scores, indicating that occupational pressures are rendering some consultant posts ‘problem posts', leading to problematic levels of psychological distress among some consultants.Clinical ImplicationsAlthough consultant psychiatrists are more satisfied than not with their jobs, steps need to be taken to address the causes of ‘problem posts', to reduce attrition in the most pressured individuals.
Residual Ductal Carcinoma In Situ in Patients With Complete Eradication of Invasive Breast Cancer After Neoadjuvant Chemotherapy Does Not Adversely Affect Patient Outcome
Authors: Mazouni Chafika , Peintinger Florentia , Wan-Kau Shu , Andre Fabrice , Gonzalez-Angulo Ana M. , Symmans W. Fraser , Meric-Bernstam Funda , Valero Vicente , Hortobagyi Gabriel N. , Pusztai Lajos 
Published: June 2007

Purpose To determine whether residual ductal carcinoma in situ (DCIS) after completion of preoperative chemotherapy affects the outcome of patients with histologically defined complete eradication of invasive cancer. Patients and Methods Retrospective analysis of a database including 2,302 breast cancer patients treated with neoadjuvant chemotherapy at The University of Texas M.D. Anderson Cancer Center between 1980 and 2004 was performed. The overall survival (OS), disease-free survival (DFS), and local recurrence-free survival were compared for patients with no residual invasive or in situ cancer (pathologic complete response [pCR]) and patients with no residual invasive cancer but persistent in situ disease (pCR+DCIS). Results The mean follow-up time was 250 months. Of the 2,302 treated patients, 78 (3.4%) had pCR, 199 (8.6%) had pCR+DCIS, and 2,025 (88%) had residual invasive cancer. For patients with pCR and pCR+DCIS, the 5-year DFS rates (87.1% in both groups) and 10-year DFS rates (81.3% v 81.7%, respectively) were similar; the 5-year OS rates (91.9% v 92.5%, respectively) and 10-year OS rates (91.8% v 92.5%, respectively) were also similar and significantly better than the rate of patients with residual invasive cancer (74.4%; P < .001). The 5-year locoregional recurrence-free survival rates were also not different between patients with pCR (92.8%; 95% CI, 86.1% to 96.4%) and patients with pCR+DCIS (90.9%; 95% CI, 77.3% to 96.5%; P = .63). Conclusion Residual DCIS in patients who experience complete eradication of the invasive cancer in the breast and lymph nodes does not adversely affect survival or local recurrence rate. Inclusion of patients with residual DCIS in the definition of pCR is justified when this outcome is used as an early surrogate for long-term survival.
Cell Cycle Regulators and Outcome of Adjuvant Cisplatin-Based Chemotherapy in Completely Resected Non–Small-Cell Lung Cancer: The International Adjuvant Lung Cancer Trial Biologic Program
Authors: Filipits Martin , Pirker Robert , Dunant Ariane , Lantuejoul Sylvie , Schmid Katharina , Huynh Anh , Haddad Vincent , André Fabrice , Stahel Rolf , Pignon Jean-Pierre , Soria Jean-Charles , Popper Helmut H. , Le Chevalier Thierry , Brambilla Elisabeth 
Published: June 2007

Purpose The International Adjuvant Lung Cancer Trial (IALT) demonstrated that adjuvant cisplatin-based chemotherapy improves the survival of patients with completely resected non–small-cell lung cancer (NSCLC). The purpose of our study was to determine whether cell cycle regulators are of prognostic and/or predictive value in patients who were enrolled onto the IALT. Patients and Methods Expression of p27Kip1, p16INK4A, cyclin D1, cyclin D3, cyclin E, and Ki-67 was immunohistochemically assessed in tumor specimens obtained from 778 IALT patients. Prognostic and predictive analyses were based on Cox models adjusted for clinical and pathologic parameters. Results There was a relationship between p27Kip1 status and benefit of cisplatin-based chemotherapy (test for interaction, P = .02). Among patients with p27Kip1-negative tumors, cisplatin-based chemotherapy resulted in longer overall survival compared with controls (adjusted hazard ratio [HR] for death = 0.66; 95% CI, 0.50 to 0.88; P = .006). In patients with p27Kip1-positive tumors, overall survival was not different between patients treated with cisplatin-based chemotherapy and controls (adjusted HR for death = 1.09; 95% CI, 0.82 to 1.45; P = .54). The other cell cycle regulators and Ki-67 did not predict benefit of adjuvant cisplatin-based chemotherapy. None of these biomarkers was significantly associated with overall survival of the patients in the total study population. Conclusion NSCLC patients with p27Kip1-negative tumors benefit from adjuvant cisplatin-based chemotherapy after complete tumor resection. Before establishing p27Kip1 as a routine marker for selection of patients for adjuvant chemotherapy, the predictive value of p27Kip1 has to be confirmed in patients from other trials.
Multicenter Phase II Study of Fertility-Sparing Treatment With Medroxyprogesterone Acetate for Endometrial Carcinoma and Atypical Hyperplasia in Young Women
Authors: Ushijima Kimio , Yahata Hideaki , Yoshikawa Hiroyuki , Konishi Ikuo , Yasugi Toshiharu , Saito Toshiaki , Nakanishi Toru , Sasaki Hiroshi , Saji Fumitaka , Iwasaka Tsuyoshi , Hatae Masayuki , Kodama Shoji , Saito Tsuyoshi , Terakawa Naoki , Yaegashi Nobuo , Hiura Masamichi , Sakamoto Atsuhiko , Tsuda Hitoshi , Fukunaga Masaharu , Kamura Toshiharu 
Published: June 2007

Purpose To assess the efficacy of fertility-sparing treatment using medroxyprogesterone acetate (MPA) for endometrial carcinoma (EC) and atypical endometrial hyperplasia (AH) in young women. Patients and Methods This multicenter prospective study was carried out at 16 institutions in Japan. Twenty-eight patients having EC at presumed stage IA and 17 patients with AH at younger than 40 years of age were enrolled. All patients were given a daily oral dose of 600 mg of MPA with low-dose aspirin. This treatment continued for 26 weeks, as long as the patients responded. Histologic change of endometrial tissue was assessed at 8 and 16 weeks of treatment. Either estrogen-progestin therapy or fertility treatment was provided for the responders after MPA therapy. The primary end point was a pathologic complete response (CR) rate. Toxicity, pregnancy rate, and progression-free interval were secondary end points. Results CR was found in 55% of EC cases and 82% of AH cases. The overall CR rate was 67%. Neither therapeutic death nor irreversible toxicities were observed; however, two patients had grade 3 body weight gain, and one patient had grade 3 liver dysfunction. During the 3-year follow-up period, 12 pregnancies and seven normal deliveries were achieved after MPA therapy. Fourteen recurrences were found in 30 patients (47%) between 7 and 36 months. Conclusion The efficacy of fertility-sparing treatment with a high-dose of MPA for EC and AH was proven by this prospective trial. Even in responders, however, close follow-up is required because of the substantial rate of recurrence.
Customizing Cisplatin Based on Quantitative Excision Repair Cross-Complementing 1 mRNA Expression: A Phase III Trial in Non–Small-Cell Lung Cancer
Authors: Cobo Manuel , Isla Dolores , Massuti Bartomeu , Montes Ana , Sanchez Jose Miguel , Provencio Mariano , Viñolas Nuria , Paz-Ares Luis , Lopez-Vivanco Guillermo , Muñoz Miguel Angel , Felip Enriqueta , Alberola Vicente , Camps Carlos , Domine Manuel , Sanchez Jose Javier , Sanchez-Ronco Maria , Danenberg Kathleen , Taron Miquel , Gandara David , Rosell Rafael 
Published: June 2007

Purpose Although current treatment options for metastatic non–small-cell lung cancer (NSCLC) rely on cisplatin-based chemotherapy, individualized approaches to therapy may improve response or reduce unnecessary toxicity. Excision repair cross-complementing 1 (ERCC1) has been associated with cisplatin resistance. We hypothesized that assigning cisplatin based on pretreatment ERCC1 mRNA levels would improve response. Patients and Methods From August 2001 to October 2005, 444 stage IV NSCLC patients were enrolled. RNA was isolated from pretreatment biopsies, and quantitative real-time reverse transcriptase PCR assays were performed to determine ERCC1 mRNA expression. Patients were randomly assigned in a 1:2 ratio to either the control or genotypic arm before ERCC1 assessment. Patients in the control arm received docetaxel plus cisplatin. In the genotypic arm, patients with low ERCC1 levels received docetaxel plus cisplatin, and those with high levels received docetaxel plus gemcitabine. The primary end point was the overall objective response rate. Results Of 444 patients enrolled, 78 (17.6%) went off study before receiving one cycle of chemotherapy, mainly due to insufficient tumor tissue for ERCC1 mRNA assessment. Of the remaining 346 patients assessable for response, objective response was attained by 53 patients (39.3%) in the control arm and 107 patients (50.7%) in the genotypic arm (P = .02). Conclusion Assessment of ERCC1 mRNA expression in patient tumor tissue is feasible in the clinical setting and predicts response to docetaxel and cisplatin. Additional studies are warranted to optimize methodologies for ERCC1 analysis in small tumor samples and to refine a multibiomarker profile predictive of patient outcome.
Vaccination of Patients With Advanced Non–Small-Cell Lung Cancer With an Optimized Cryptic Human Telomerase Reverse Transcriptase Peptide
Authors: Bolonaki Irini , Kotsakis Athanassios , Papadimitraki Elsa , Aggouraki Despoina , Konsolakis George , Vagia Aphrodite , Christophylakis Charalambos , Nikoloudi Irini , Magganas Elefterios , Galanis Athanassios , Cordopatis Paul , Kosmatopoulos Kostas , Georgoulias Vassilis , Mavroudis Dimitris 
Published: June 2007

Purpose To evaluate the immunological and clinical response as well as the safety of the optimized peptide telomerase reverse transcriptase p572Y (TERT572Y) presented by HLA-A*0201 in patients with advanced non–small-cell lung cancer (NSCLC). Patients and Methods Twenty-two patients with advanced NSCLC and residual (n = 8) or progressive disease (PD; n = 14) following chemotherapy and/or radiotherapy received two subcutaneous injections of the optimized TERT572Y peptide followed by four injections of the native TERT572 peptide administered every 3 weeks. Peptide-specific immune responses were monitored by enzyme-linked immunosorbent spot assay and/or TERT572Y pentamer staining. Results Twelve (54.5%) of 22 patients completed the vaccination program. Toxicity consisted primarily of local skin reactions. TERT572-specific CD8+ cells were detected in 16 (76.2%) of 21 patients after the second vaccination, and 10 (90.9%) of 11 patients after the sixth vaccination. Stable disease (SD) occurred in eight (36.4%) of 22 vaccinated patients, with three (13.6%) having had PD before entering the study. The median duration of SD was 11.2 months. After a median follow-up of 10.0 months, patients with early developed immunological response (n = 16) had a significantly longer time to progression and overall survival (OS) than nonresponders (n = 5; log-rank tests P = .046 and P = .012, respectively). The estimated median OS was 30.0 months (range, 2.8 to 40.0 months) and 4.1 months (range, 2.4 to 10.9 months) for responders and nonresponders, respectively. Conclusion TERT572Y peptide vaccine is well tolerated and effective in eliciting a specific T cell immunity. Immunological response is associated with prolonged survival. These results are encouraging and warrant further evaluation in a randomized study.
Gill remodeling in fish – a new fashion or an ancient secret?
Authors: Nilsson Göran E. 
Published: June 2007

SUMMARYWhile a large respiratory surface area is good for gas exchange, it also poses several problems, including energetically unfavorable fluxes of water and ions. As a result, fishes appear to have a respiratory surface area that is matched to their oxygen demands. When faced with changes in their need for oxygen uptake, e.g. through altered physical activity or altered ambient oxygen levels, fishes have long been known to make two different adjustments:(1) to change the water flow over the gills or (2) to change the blood flow inside the gills. It has recently become clear that at least some teleosts have a third option: to reversibly remodel the gill morphology. Studies have shown that the lamellae of crucian carp Carassius carassius gills are embedded in a cell mass during normoxic conditions or at low temperature,while much of this cell mass dies off in hypoxia and at higher temperatures,thereby exposing a much larger respiratory surface area. Gill remodeling has subsequently been seen in two more cyprinids and in the mangrove killifish Kryptolebias marmoratus. In the latter case it appears to be an adaptation to periods of air exposure. Gill remodeling in response to changing respiratory requirements could be an ancient mechanism, occurring in many more teleosts than presently known. It is tempting to suggest that gill remodeling has been overlooked in many fishes, either because it is relatively subtle in some species, or because fishes are often kept at the warmer end of their temperature range where they need fully protruding lamellae.
Acoustic feature recognition in the dogbane tiger moth,Cycnia tenera
Authors: Fullard James H. , Ratcliffe John M. , Christie Christopher G. 
Published: June 2007

SUMMARYCertain tiger moths (Arctiidae) defend themselves against bats by phonoresponding to their echolocation calls with trains of ultrasonic clicks. The dogbane tiger moth, Cycnia tenera, preferentially phonoresponds to the calls produced by attacking versus searching bats, suggesting that it either recognizes some acoustic feature of this phase of the bat's echolocation calls or that it simply reacts to their increased power as the bat closes. Here, we used a habituation/generalization paradigm to demonstrate that C. tenera responds neither to the shift in echolocation call frequencies nor to the change in pulse duration that is exhibited during the bat's attack phase unless these changes are accompanied by either an increase in duty cycle or a decrease in pulse period. To separate these features, we measured the moth's phonoresponse thresholds to pulsed stimuli with variable versus constant duty cycles and demonstrate that C. tenerais most sensitive to echolocation call periods expressed by an attacking bat. We suggest that, under natural conditions, C. tenera identifies an attacking bat by recognizing the pulse period of its echolocation calls but that this feature recognition is influenced by acoustic power and can be overridden by unnaturally intense sounds.
The vagus nerve mediates cardio-respiratory coupling that changes with metabolic demand in a temperate nototheniod fish
Authors: Campbell Hamish A. , Egginton Stuart 
Published: June 2007

SUMMARY
The extent and efficiency of cardio-respiratory coupling (CRC) in teleost fishes is unclear. We simultaneously monitored heart rate (fH) and ventilation rate (fV) in Paranotothenia angustata, and applied modern power spectral analysis (PSA) mathematics to examine the rate association under varying levels of oxygen consumption(ṀO2). At low ṀO2 (0.94 mmol O2 kg–1 h–1) there was a correspondingly low fH and fV(25.5±2.4 min–1 and 29.2±2.6 min–1, respectively). Heart rate variability (HRV) consisted of oscillatory components caused by periodic vagal inhibition of the heart beat. Cross-spectral analysis showed that fH and fV were coupled, with the response lag in heart beat being approximately one seventh of each ventilation cycle. Ingestion of food elevated ṀO2(1.99±0.02 mmol O2 kg–1h–1) and increased both fH and fV (45±2.3 min–1 and 52±2 min–1, respectively, P&lt;0.05), but CRC was maintained despite a reduction in HRV. The elevated stress caused by handling and placement of fish into respirometry chambers raised fHand fV to a similar rate as observed after feeding,although high-frequency (&gt;0.2 Hz) oscillations in fHwere lacking and ṀO2 was lower(1.82±0.03 mmol O2 kg–1h–1, P&lt;0.05). Subsequent cardiac vagotomy elevated fH and fV (55.5±0.8 min–1 and 48.2±0.7 min–1,respectively; P&lt;0.05) but abolished all HRV and CRC, although ṀO2 was significantly less for a given fH and fV compared to intact fish. Thus, P. angustataexhibits vagally mediated CRC, and the association between fH and fV varies according to oxygen demand.
Modulation of locomotor activity in larval zebrafish during light adaptation
Authors: Burgess Harold A. , Granato Michael 
Published: June 2007

SUMMARYThe neural basis of behavioral choice in vertebrates remains largely unknown. Zebrafish larvae have a defined locomotor repertoire as well as a simple nervous system and are therefore an attractive vertebrate system in which to study this process. Here we describe a high-throughput system for quantifying the kinematics of motor events in zebrafish larvae in order to measure the initiation frequency of different maneuvers. We use this system to analyze responses to photic stimuli and find that larvae respond to changes in illumination with both acute responses and extended behavioral programs. Reductions in illumination elicit large angle turns, distinct from startle responses, which orient larvae toward the source of light. In continuing darkness, larvae are transiently hyperactive before adopting a quiescent state. Indeed, locomotor activity is controlled by the state of light or dark adaptation similar to masking phenomena in higher vertebrates where light directly regulates motor activity. We propose that regulation of motor activity by photic stimuli in zebrafish larvae serves a behavioral goal of maximizing exposure to well lit environments optimal for feeding.
Effects of two bitter substances on olfactory conditioning in the moth Heliothis virescens
Authors: Jørgensen Kari , Stranden Marit , Sandoz Jean-Christophe , Menzel Randolf , Mustaparta Hanna 
Published: June 2007

SUMMARY
In nature, moths encounter nutritious and toxic substances in plants, and thus have to discriminate between a diversity of tastants. Whereas olfactory learning allowing memory of nutritious plants is well demonstrated, little is known about learning and memory of toxic items in adult lepidopterans. Moths may use bitter substances to detect and possibly learn to avoid noxious plants. We have studied the physiological and behavioural effects of two bitter substances, quinine and sinigrin, on the moth Heliothis virescens. Electrophysiological recordings showed responses to both compounds in gustatory receptor neurons on the antennae. The response patterns suggested a peripheral discrimination between quinine and sinigrin. We evaluated their putative aversive effect in an appetitive conditioning context where the moths learned to associate an odour with sucrose. We first aimed at enhancing olfactory conditioning of the proboscis extension response by testing the effect of the sucrose concentration on acquisition, retention and extinction. 2 mol l–1 and 3 mol l–1 sucrose concentration gave similar acquisition, retention and extinction performances. Experiments involving pre-exposure or facilitated extinction with an odour paired with quinine, sinigrin or no tastant showed a latent inhibitory effect,as well as an aversive effect of quinine and, to a lesser extent, of sinigrin. The results suggested that the two tastants may act as negative reinforcers in H. virescens.