bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of Incipient Stress Corrosion Cracking Damage in Primary Loop Piping Using Fiber Optic Strain Gages
Authors: Jackson Benjamin K. , Bosko David , Cronin Michael T. , Warwick Jonnathan L.W. , Wall James J. 
Published: March 2024

Abstract
Current nondestructive examination (NDE) technology detection capabilities limit our ability to detect stress corrosion cracking (SCC) damage until it has progressed significantly. This work describes the continued development of an in-situ monitoring technique to detect and characterize mechanical damage caused by SCC, allowing the detection of the incipient stages of damage to components/piping. The application of this study is to prevent failures in the primary cooling loop piping in nuclear plants. The main benefit to the industry will be improved safety and component lifetime assessment with fewer inspections. The technique utilizes high resolution fiber optic strain gages mounted on the pipe outside diameter (OD). This technique has successfully detected changes in the residual stress profile caused by a crack propagating from the pipe inside diameter (ID). The gages have a resolution of &lt; 1 με. It has been shown experimentally for different crack geometries that the gages can readily detect the changes of approximately 10-60 με caused on the OD of the pipe due to crack initiation on the ID. This paper focuses on the latest in the development of the technology. Details of the previous work in this effort may be found in References 1 through 3. A short summary is provided in this paper. The main recent development was the full scale accelerated SCC cracking in boiling magnesium chloride (MgCl2) experiment. In conjunction with experimentation, both 2D and 3D finite element (FEA) models with thermal and mechanical analyses have been developed to simulate the changes in residual stresses in a welded pipe section as a SCC crack progresses.
High Temperature Oxidation Behavior of Fe-9Cr Steel In CO2-O2 Gas Mixture
Authors: Hayashi Shigenari , Kaya Kietaro , Ukai Shigeharu 
Published: March 2024

Abstract
The high-temperature oxidation of Fe-9Cr-1Mo steel in a CO2 environment, with varying oxygen content (0.6-3%), was investigated at 700°C. While the steel heavily oxidized in pure CO2, the oxidation mass gain decreased significantly with increasing oxygen content. Microscopic analysis revealed the formation of Fe-rich nodules with an internal Cr-carbide layer beneath them. Notably, the number of nodules decreased with increasing oxygen content but remained independent of the oxidation time. To explain these observations, the authors propose that “intrinsic” defects within the initially formed protective Cr2O3 scale facilitated gas permeation. This mechanism is believed to be responsible for the observed dependence of nodule formation on the oxygen content in the gas mixtures.
Hot Corrosion Properties of Ni-Based Alloys Used in an Advanced-USC Boiler
Authors: Tanaka Yasuhiro , Komai Nobuyoshi , Takei Yasuhiro 
Published: March 2024

Abstract
Six types of solution treated Ni-based alloy plates having a thickness of 25mm, namely Alloy 617, Alloy 263, Alloy 740, Alloy 141, HR6W (45Ni-23Cr-7W) and HR35 (50Ni-30Cr-4W-Ti) for advanced-USC boilers, were subjected to corrosion testing. In addition, three types of conventional ferritic and five types of conventional austenitic stainless tubes were also tested to compare their corrosion properties. Hot corrosion tests were conducted in order to assess the effects of temperature, material composition and coal ash composition on hot corrosion. The maximum average metal loss and the maximum corrosion rate were observed under 700°C test conditions. Cr content in the materials played an important role in the corrosion rate, with higher Cr content materials tending to show lower rates. However, Ni-based alloy materials showed slightly greater corrosion rates than those of stainless steels having equivalent Cr content in the over-700°C test condition. It was considered that rich Ni in the alloys easily reacted with sulfur, thus forming corrosion products having low melting points, such that corrosion was accelerated. The concentration of Fe2O3 and NiO in the synthetic coal ash was also observed to affect the corrosion rate.
Expression level of non-coding (MiR-155) gene as biomarker for severity of coronaviruses infection among vaccinated and non-vaccinated Iraqi patients
Authors: Kadhim Halah , Ghareeb Abdulameer , Alhilal Mohammed 
Published: March 2024

BACKGROUND: The COVID-19 pandemic caused by SARS-CoV-2 is influenced by genetic and epigenetic factors, including miR-155, which affects immune cell and virus functions and laboratory biomarkers. OBJECTIVE: To evaluates miR-155’s role as a biomarker for SARS-CoV-2 detection and monitoring, examining its significance in identifying infection in both vaccinated and unvaccinated individuals using ROC curve analysis. METHODS: Blood samples were collected from 70 patients who attended Medical City Hospital in Baghdad from June 2022 to April 2023 and were determined to be associated with SARS-CoV-2 (35 patients were hospitalized at the Intensive Care Units due to the severity of their symptoms while the other 35 were left in the hospital upon treatment.). Additionally, 35 samples were collected as a healthy control group. RESULTS: The expression level of miR-155 in the serum of samples showed a high level (fold change: 9.81 ± 5.50) in the severe patients’ group in comparison with the moderate patients’ group (fold change: 4.17 ± 2.93) and healthy group (fold change: 1.08 ± 0.01). To assess the performance of miR-155 and laboratory biomarkers, a (ROC) curve was utilized to determine the sensitivity and specificity. CONCLUSIONS: The miR-155 gene, overexpressed in SARS-CoV-2 patients, correlates with disease activity and severity, potentially serving as a biomarker for diagnosis and a potential therapeutic target.
Principales resultados y conclusiones de la revisión intermedia del Marco Financiero Plurianual UE 2021-2027
Authors: Sánchez Cifuentes Victoria , Carcelén Ordóñez María Victoria 
Published: March 2024

El 20 de junio de 2023 la Comisión Europea publicó su propuesta de revisión del Marco Financiero Plurianual (MFP) 2021-2027, integrado por un paquete legislativo que incluye la creación de un Mecanismo para Ucrania, el establecimiento de una Plataforma de Tecnologías Estratégicas para Europa (STEP, por sus siglas en inglés), así como un refuerzo en la política migratoria, en su dimensión interior y exterior de la UE, y la actualización de los costes de administración de las instituciones comunitarias.
El 1 de febrero el Consejo llegó a un acuerdo político unánime sobre los elementos principales del paquete legislativo.
Los colegisladores llegaron a acuerdos sobre los textos legislativos del paquete en los primeros diez días de febrero.
El 29 de febrero está previsto el acto institucional de firma del acuerdo sobre la revisión por las instituciones y, el 1 de marzo, la publicación en el Diario Oficial de la UE, así como su inmediata entrada en vigor.
El resultado final de la revisión es menos ambicioso que la propuesta inicial de la Comisión. No obstante, proporcionará la financiación necesaria para atender los desafíos más urgentes, en concreto el apoyo financiero a Ucrania y el refuerzo de la política migratoria de la Unión.
Implementasi Kewenangan Penyuluhan Hukum oleh Notaris
Authors: Tenggara Ananda Pradhitya 
Published: March 2024

Penelitian ini bertujuan untuk menganalisis konsep sosialisasi undang-undang dalam Undang-Undang Jabatan Notaris dan menganalisis bentuk sosialisasi hukum yang dapat dilakukan oleh Notaris. Tesis ini diharapkan dapat bermanfaat sebagai sumber kajian untuk mengembangkan ilmu hukum secara teoritis dan sebagai pedoman bagi Notaris dalam melaksanakan tugas dan kewajibannya memberikan sosialisasi hukum agar tidak melampaui batas kewenangan secara praktis. Kewenangan Notaris untuk memberikan sosialisasi hukum kepada pihak-pihak yang berkepentingan dalam pembuatan akta otentik merupakan bentuk pemberian pemahaman hukum terkait dengan perbuatan hukum yang akan dituangkan dalam Akta sesuai dengan ketentuan peraturan perundang-undangan. Kewenangan Notaris dalam memberikan sosialisasi hukum kepada kliennya dapat dibedakan menjadi 2 (dua) bentuk yaitu sosialisasi hukum yang diikuti dengan pembuatan akta dan sosialisasi hukum tanpa diikuti dengan pembuatan akta. Bentuk yang pertama, Notaris harus memberikan penjelasan mengenai keadaan hukum yang sebenarnya sesuai dengan ketentuan peraturan perundang-undangan yang berlaku, untuk menjelaskan hak dan kewajiban para pihak. Bentuk yang kedua adalah kewenangan Notaris terkait dengan kewenangan untuk menolak memberikan sosialisasi hukum kepada para pihak berdasarkan alasan yang sah, dibenarkan oleh peraturan perundang-undangan yang berlaku dan pedoman perilaku Notaris
Susceptibilidad antimicrobiana de bacterias causantes de infecciones del tracto urinario en mujeres y niñas
Authors: Barbecho Quizhpi Edisson Javier , Andrade Campoverde Diego 
Published: March 2024

Introducción. La infección del tracto urinario forma parte del grupo de las infecciones más frecuentes en los seres humanos, por lo que se la considera un problema de salud pública al presentar altas tasas de incidencia y morbilidad en la población pediátrica y adulta en diferentes regiones del mundo, siendo la mayor causa de estas de origen bacteriano, por lo cual los tratamientos se basan en la antibioticoterapia. Sin embargo, con el paso de los años se ha observado a nivel global el fracaso en los tratamientos empíricos debido a la resistencia bacteriana, presentando mayor incidencia países subdesarrollados. Objetivo. Caracterizar las diferentes especies bacterianas causantes de infección del tracto urinario en mujeres que acuden a consulta en la Fundación Humanitaria Pablo Jaramillo Crespo durante el año 2022, además identificar al agente causal más común y su clasificación dependiendo de si estos presentan o no la enzima betalactamasa de espectro extendido (BLEE). Metodología. Estudio descriptivo de cohorte transversal, documental secundario de muestreo no probabilístico por cobertura total. Resultados. De 304 urocultivos positivos se identificó un 62.5% casos de infección del tracto urinario en mujeres adultas y 37.5% en niñas, presentándose a Escherichia coli como el agente etiológico más común 82.2%, seguido de Proteus mirabilis 11.5%, Klebsiella pneumoniae 1.6% y 4.7% de otros microorganismos granmenegativos. Un 11.5% de casos positivos para la presencia de BLEE, siendo Escherichia coli el agente etiológico con más casos positivos para este mecanismo de resistencia con un mayor número de casos en la población infantil siendo de 21 casos. Conclusión. EL agente etiológico más común causante de Infección del tracto urinario en la población de esta casa de salud es Escherichia coli, presentándose un mayor porcentaje de casos de betalactamasa de espectro extendido en la población infantil, lo que demuestra la importancia de realizar un urocultivo y antibiograma para plantear un correcto esquema de tratamiento en los pacientes y así evitar que los microorganismos generen mecanismos de resistencia bacteriana. Área de estudio: Salud, Laboratorio clínico
PENGABDIAN MASYARAKAT MELALUI PEMBERIAN PENDIDIKAN KESEHATAN PENTINGNYA KESEHATAN MENTAL DAN EMOSIONAL REMAJA SMA
Authors: Fitri Nurwijaya , Mardiana Nova , Sari Indah Permata 
Published: March 2024

Menurut Badan Kesehatan Dunia tahun 2018, remaja adalah individu yang masuk di kisaran usia 10-19 tahun, berdasarkan Peraturan Menteri Kesehatan Republik Indonesia (Permenkes RI) nomor 25 tahun 2014, remaja merupakan seseorang yang berada direntang usia 10-18 tahun. Menurut World Health Organization (2020), angka kejadian permasalahan gangguan kesehatan mental di dunia dengan rentang remaja usia 10 sampai 19 tahun dan terus terjadi peningkatan 16% setiap tahunnya. Gangguan kesehatan mental yang terjadi diawali usia mulai dari 14 tahun, dan yang terjadi mayoritas kasus yang terdeteksi sangat minim sekali dan perlu di lakukan pencegahan sejak dini. Terlepas dari semua masalah kesehatan mental tersebut, remaja yang sedang memasuki masa pubertas sangat beresiko dan paling rentan mengalami gangguan kesehatan jika tidak dapat beradaptasi dan memanajemen masalah yang di hadapi. Berdasarkan hasil wawancara dengan salah satu remaja di SMA tempat pengabdian, didapatkan informasi bahwa siswa tersebut belum pernah mendapatkan informasi terkait pentingnya menjaga kesehatan mental dan emosional. Tujuan dari kegiatan ini yaitu untuk menambah informasi, knowledge dan kemampuan remaja SMA tentang pentingnya menjaga kesehatan mental dan emosional. Kegiatan pengabdian ini dilaksanakan dalam bentuk sosialisasi, pretest, pendidikan kesehatan menggunakan powertpoint, leaflet dan posttest. Kegiatan diikuti oleh remaja SMA Bahrul Ulum Sungailiat berjumlah 40 orang. Hasil kegiatan ini menggambarkan adanya peningkatan pengetahuan Remaja dalam hal informasi pentingnya menjaga kesehatan mental dan emosional dengan selisih nilai pre dan posttest sebesar 20%. Kesimpulan dengan pengaplikasian pendidikan kesehatan pada remaja sangat efektif dalam hal meningkatkan informasi, pengetahuan dan diharapkan kegiatan ini bisa berimplikasi terhadap pengetahuan dan motivasi remaja terkait pentingnya menjaga kesehatan mental dan emosional sejak dini.
Design of a simplified cranial substitute with a modal behavior close to that of a human skull
Authors: Elster Natacha , Boutillier Johanna , Bourdet Nicolas , Magnan Pascal , Naz Pierre , Willinger Rémy , Deck Caroline 
Published: March 2024

Individuals exposed to the propagation of shock waves generated by the detonation of explosive charges may suffer Traumatic Brain Injury. The mechanism of cranial deflection is one of many hypotheses that could explain the observed brain damage. To investigate this physical phenomenon in a reproducible manner, a new simplified cranial substitute was designed with a mechanical response close to that of a human skull when subjected to this type of loading. As a first step, a Finite Element Model was employed to dimension the new substitute. The objective was indeed to obtain a vibratory behavior close to that of a dry human skull over a wide range of frequencies up to 10 kHz. As a second step, the Finite Element Model was used together with Experimental Modal Analyses to identify the vibration modes of the substitute. A shaker excited the structure via a metal rod, while a laser vibrometer recorded the induced vibrations at defined measurement points. The results showed that despite differences in material properties and geometry, the newly developed substitute has 10/13 natural frequencies in common with those of dry human skulls. When filled with a simulant of cerebral matter, it could therefore be used in future studies as an approximation to assess the mechanical response of a simplified skull substitute to a blast threat.
Significance of the Wnt signaling pathway in coronary artery atherosclerosis
Authors: Khan Kashif , Yu Bin , Tardif Jean-Claude , Rhéaume Eric , Al-Kindi Hamood , Filimon Sabin , Pop Cristina , Genest Jacques , Cecere Renzo , Schwertani Adel 
Published: March 2024

IntroductionThe progression of coronary atherosclerosis is an active and regulated process. The Wnt signaling pathway is thought to play an active role in the pathogenesis of several cardiovascular diseases; however, a better understanding of this system in atherosclerosis is yet to be unraveled.MethodsIn this study, real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting were used to quantify the expression of Wnt3a, Wnt5a, and Wnt5b in the human coronary plaque, and immunohistochemistry was used to identify sites of local expression. To determine the pathologic significance of increased Wnt, human vascular smooth muscle cells (vSMCs) were treated with Wnt3a, Wnt5a, and Wnt5b recombinant proteins and assessed for changes in cell differentiation and function.ResultsRT-PCR and Western blotting showed a significant increase in the expression of Wnt3a, Wnt5a, Wnt5b, and their receptors in diseased coronary arteries compared with that in non-diseased coronary arteries. Immunohistochemistry revealed an abundant expression of Wnt3a and Wnt5b in diseased coronary arteries, which contrasted with little or no signals in normal coronary arteries. Immunostaining of Wnt3a and Wnt5b was found largely in inflammatory cells and myointimal cells. The treatment of vSMCs with Wnt3a, Wnt5a, and Wnt5b resulted in increased vSMC differentiation, migration, calcification, oxidative stress, and impaired cholesterol handling.ConclusionsThis study demonstrates the upregulation of three important members of canonical and non-canonical Wnt signaling pathways and their receptors in coronary atherosclerosis and shows an important role for these molecules in plaque development through increased cellular remodeling and impaired cholesterol handling.
The clinical use of remote parameter testing during cardiac implantable electronic devices implantation procedures: a single center, randomized, open-label, non-inferiority trial
Authors: Xiong Shiqiang , Qin Shujuan , Tong Lin , Long Yu , Luo Yan , Feng Qiao , Peng Xiufen , Jiang Maoling , Xiong Feng , Li Jin , Zhang Yangchun , Zhang Zhen , Liu Hanxiong , Cai Lin 
Published: March 2024

BackgroundA novel non-contact system for remote parameter testing and reprogramming offers an alternative method for assessing device parameters during cardiac implantable electronic devices (CIEDs) implantation without the need for physical contact with the manufacturer's clinical service technician. The safety and feasibility of using this system in CIEDs implantation procedures remains to be determined.ObjectiveEvaluate the safety and feasibility of remote parameter testing in CIEDs implantation procedures.MethodsA single center, randomized, open-label, non-inferiority trial (ChiCTR2200057587) was conducted to compare the two approaches for interrogating CIEDs during implantation procedures: routine interrogation performed by on-site technicians or remote interrogation performed by technicians using the 5G-Cloud Technology Platform. Patients aged ≥18 years and elected to receive CIEDs were eligible for inclusion. The primary endpoint was the completion rate of the parameter test. Safety and efficiency were evaluated in all randomly assigned participants.ResultsA total of 480 patients were finally enrolled and were randomly assigned to routine group (n = 240) or remote group (n = 240). The primary endpoint was achieved by 100% in both groups (P = 0.0060 for noninferiority). The parameters of sensing, threshold, and impedance regarding the right atrium, right ventricle, and left ventricle had no statistical significance between the two groups (P &gt; 0.05). Procedure time, parameter testing time, and both duration and dose of x-ray irradiation were not significantly different between the two groups (P &gt; 0.05). Shut-open door frequency was significantly higher in the routine group than the remote group [6.00 (4.00, 8.00) vs. 0, P &lt; 0.0001]. Notably, no clinical or technical complications were observed in the remote group.ConclusionsRemote parameter testing is safe and feasible across various devices implantation procedures. The utilization of remote parameter testing and reprogramming could represent an innovative approach to improve healthcare accessibility and unlock the full potential of secondary centers in managing CIEDs.
The Registration IdentificationChiCTR2200057587.
Associations of comorbid depression with cardiovascular-renal events and all-cause mortality accounting for patient reported outcomes in individuals with type 2 diabetes: a 6-year prospective analysis of the Hong Kong Diabetes Register
Authors: Yeung Yiu-Lam , Lee Ka-Long , Lau Eric SH. , Yung Tsun-Fung , Yang Aimin , Wu Hongjiang , Wong Kelly TC. , Kong Alice PS. , Chow Elaine YK. , Ma Ronald CW. , Yeung Theresa , Loo Kit-man , Ozaki Risa , Luk Andrea OY. , Lui Juliana NM. , Chan Juliana CN. 
Published: March 2024

BackgroundPsychosocial status and patient reported outcomes (PRO) [depression and health-related quality-of-life (HRQoL)] are major health determinants. We investigated the association between depression and clinical outcomes in Chinese patients with type 2 diabetes (T2D), adjusted for PRO.MethodsUsing prospective data from Hong Kong Diabetes Register (2013-2019), we estimated the hazard-ratio (HR, 95%CI) of depression (validated Patient Health Questionnaire 9 (PHQ-9) score≥7) with incident cardiovascular disease (CVD), ischemic heart disease (IHD), chronic kidney disease (CKD: eGFR&lt;60 ml/min/1.73m2) and all-cause mortality in 4525 Chinese patients with T2D adjusted for patient characteristics, renal function, medications, self-care and HRQoL domains (mobility, self-care, usual activities, pain/discomfort, anxiety/depression measured by EQ-5D-3L) in linear-regression models.ResultsIn this cohort without prior events [mean ± SD age:55.7 ± 10.6, 43.7% women, median (IQR) disease duration of 7.0 (2.0-13.0) years, HbA1c, 7.2% (6.6%-8.20%), 26.4% insulin-treated], 537(11.9%) patients had depressive symptoms and 1923 (42.5%) patients had some problems with HRQoL at baseline. After 5.6(IQR: 4.4-6.2) years, 141 patients (3.1%) died, 533(11.8%) developed CKD and 164(3.6%) developed CVD. In a fully-adjusted model (model 4) including self-care and HRQoL, the aHR of depression was 1.99 (95% confidence interval CI):1.25-3.18) for CVD, 2.29 (1.25-4.21) for IHD. Depression was associated with all-cause mortality in models 1-3 adjusted for demographics, clinical characteristics and self-care, but was attenuated after adjusting for HRQoL (model 4- 1.54; 95%CI: 0.91-2.60), though HR still indicated same direction with important magnitude. Patients who reported having regular exercise (3-4 times per week) had reduced aHR of CKD [0.61 (0.41–0.89)]. Item 4 of PHQ-9 (feeling tired, little energy) was independently associated with all-cause mortality with aHR of 1.66 (1.30-2.12).ConclusionDepression exhibits significant association with CVD, IHD, and all-cause mortality in patients with diabetes, adjusting for their HRQoL and health behaviors. Despite the association between depression and all-cause mortality attenuated after adjusting for HRQoL, the effect size remains substantial. The feeling of tiredness or having little energy, as assessed by item Q4 of the PHQ-9 questionnaire, was found to be significantly associated with an increased risk of all-cause mortality after covariate adjustments. Our findings emphasize the importance of incorporating psychiatric evaluations into holistic diabetes management.