bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early detection of occupational cholangiocarcinoma in a high-risk patient under intensive surveillance: a case study
Authors: Kounami Naoko , Maeda Sakae , Kitagawa Akihiro , Tomihara Hideo , Ushimaru Yuki , Ohara Nobuyoshi , Takeoka Tomohira , Imasato Mitsunobu , Kawabata Ryohei , Noura Shingo , Yasuhara Yumiko , Miyamoto Atsushi 
Published: March 2024

Abstract
Background
Occupational cholangiocarcinoma is associated with exposure to organic solvents, such as dichloromethane (DCM) and 1,2-dichloropropane (DCP). This report describes a case of occupational cholangiocarcinoma detected through regularly imaging following the discovery of elevated serum γ-glutamyl trans peptidase (γ-GTP) levels revealed during regular checkup.

Case presentation
A 43-year-old man who had been working in a printing company with 15 years of exposure to organic solvents presented to our hospital owing to abnormalities found during a routine checkup. Ultrasound (US) imaging revealed thickening of the gallbladder wall accompanied by gallstones, although in the blood tests, γ-GTP levels were within normal range. Given the high risk of cholangiocarcinoma development, the patient underwent regular monitoring with abdominal US and blood tests at a local doctor's office. At the age of 48, his serum γ-GTP level mildly elevated for the first time, prompting the initiation of semi-annual magnetic resonance cholangiopancreatography (MRCP). By the age of 50 years, dilation in B8 was detected, and one and a half years later, a tumor on the central side of the B8 dilation appeared. The patient was diagnosed with intrahepatic cholangiocarcinoma, which was treated with anterior sectionectomy. Pathological examination revealed an adenocarcinoma with a papillary glandular ductal structure at the root of the B8. In addition, biliary intraepithelial neoplasia (BilIN) and dysplasia have been identified around the tumor and periphery bile ducts and in noncancerous bile ducts. Postoperatively, the patient received 6 months of adjuvant chemotherapy with S-1monotherapy. Eight months after surgery, the patient remained under observation with no signs of recurrence.

Conclusions
We report a case of occupational cholangiocarcinoma detected during a prolonged period of regular follow-up after exposure to DCM and DCP. Given the delayed carcinogenesis process, occupational cholangiocarcinomas manifest long after exposure to organic solvents, therefore, ongoing screening is extremely important. Vigilance is essential to avoid underdiagnosis, particularly for individuals who are at an increased risk of developing this form of cancer. Continuous monitoring is key to the early detection and effective management of occupational cholangiocarcinoma.
Lifestyle counselling as secondary prevention in patients with minor stroke or transient ischemic attack: a randomized controlled pilot study
Authors: Liljehult Jacob , Molsted Stig , Møller Tom , Overgaard Dorthe , Christensen Thomas 
Published: March 2024

Abstract
Background
Patients with minor stroke or transient ischemic attacks have an increased risk of future strokes. These patients are often discharged home with limited specialized follow-up, although close to half of them experience cognitive deficits. Simple encouragements to avoid smoking, be physically active, and to take preventive medication are often insufficient to ensure adherence and more comprehensive interventions are needed to support the patients in adapting healthy behaviour. The aim of this study was to test the feasibility and potential effect of an early initiated, patient-centred intervention to patients with minor stroke or transient ischemic attacks targeting smoking, physical activity, and medication adherence, in a randomized, controlled pilot trial.

Methods
Hospitalized patients were randomized to usual care or an intervention consisting of health behavioural counselling based on the 5A’s model, telephone follow-up (4 and 8 weeks), and monitoring of physical activity. Follow-up time was 12 weeks. Feasibility was on the following domains: eligibility, acceptance, demand and practicality, adherence, attrition, and implementation and integration.

Results
Forty patients of 84 potentially eligible were randomized to the two treatment arms (20 intervention/20 usual care). Thirty-two completed the 12-week follow-up, while 8 were either excluded or lost to follow-up. With few changes, the intervention was feasible and possible to deliver according to the protocol.

Conclusion
It was possible to identify relevant patients who could potentially benefit from a behavioural intervention, recruit and randomize them early after admission and retain most participants in the study until follow-up and derive statistical estimates to guide the design of large-scale randomized controlled trials.

Trial registration
ClinicalTrials.gov Identifier: NCT03648957. Registered 28 August 2018.
Evaluating the role of social context and environmental factors in mediating overwintering physiology in honey bees (Apis mellifera)
Authors: Quinlan Gabriela M. , Grozinger Christina M. 
Published: March 2024

ABSTRACT
In temperate climates, honey bees show strong phenotypic plasticity associated with seasonal changes. In summer, worker bees typically only survive for about a month and can be further classified as young nurse bees (which feed the developing brood) and older forager bees. In winter, brood production and foraging halt and the worker bees live for several months. These differences in task and longevity are reflected in their physiology, with summer nurses and long-lived winter bees typically having large fat bodies, high expression levels of vitellogenin (a longevity-, nutrition- and immune-related gene), and large provisioning glands in their head. The environmental factors (both within the colony and within the surrounding environment) that trigger this transition to long-lived winter bees are poorly understood. One theory is that winter bees are an extended nurse bee state, brought on by a reduction in nursing duties in autumn (i.e. lower brood area). We examined that theory here by assessing nurse bee physiology in both the summer and autumn, in colonies with varying levels of brood. We found that season is a better predictor of nurse bee physiology than brood area. This suggests that seasonal factors beyond brood area, such as pollen availability and colony demography, may be necessary for inducing the winter bee phenotype. This finding furthers our understanding of winter bee biology, which could have important implications for colony management for winter, a critical period for colony survival.
Patient decision-making in left ventricular assist devices for destination therapy
Authors: Morrison Megan L 
Published: March 2024

Background: Heart failure is a common life-limiting disease. A destination therapy for people who will not have a heart transplant is a left ventricular assist device. Aims: To discover how patients who have a left ventricular assist device for destination therapy make decisions about their healthcare after implantation of the device. Methods: A descriptive qualitative design with semi-structured, in-depth interviews with 11 participants who are living with a left ventricular assist device for destination therapy. Findings: People with a left ventricular assist device felt they had ‘no choice’ when making decisions about their healthcare. Conclusion: Engaging with patients to contemplate present and future healthcare decisions is a complex process that includes cognitive processes within the patient. Clinicians need to be aware that a gap may occur between what is said and what is heard in communication.
Implant retention in a rabbit model of fracture-related infection
Authors: Puetzler Jan , Vallejo Diaz Alejandro , Gosheger Georg , Schulze Martin , Arens Daniel , Zeiter Stephan , Siverino Claudia , Richards Robert G. , Moriarty Thomas F. 
Published: March 2024

AimsFracture-related infection (FRI) is commonly classified based on the time of onset of symptoms. Early infections (< two weeks) are treated with debridement, antibiotics, and implant retention (DAIR). For late infections (> ten weeks), guidelines recommend implant removal due to tolerant biofilms. For delayed infections (two to ten weeks), recommendations are unclear. In this study we compared infection clearance and bone healing in early and delayed FRI treated with DAIR in a rabbit model.MethodsStaphylococcus aureus was inoculated into a humeral osteotomy in 17 rabbits after plate osteosynthesis. Infection developed for one week (early group, n = 6) or four weeks (delayed group, n = 6) before DAIR (systemic antibiotics: two weeks, nafcillin + rifampin; four weeks, levofloxacin + rifampin). A control group (n = 5) received revision surgery after four weeks without antibiotics. Bacteriology of humerus, soft-tissue, and implants was performed seven weeks after revision surgery. Bone healing was assessed using a modified radiological union scale in tibial fractures (mRUST).ResultsGreater bacterial burden in the early group compared to the delayed and control groups at revision surgery indicates a retraction of the infection from one to four weeks. Infection was cleared in all animals in the early and delayed groups at euthanasia, but not in the control group. Osteotomies healed in the early group, but bone healing was significantly compromised in the delayed and control groups.ConclusionThe duration of the infection from one to four weeks does not impact the success of infection clearance in this model. Bone healing, however, is impaired as the duration of the infection increases.Cite this article: Bone Joint Res 2024;13(3):127–135.
Egg excretion patterns of soil-transmitted helminth infections in humans following albendazole-ivermectin and albendazole treatment
Authors: Welsche Sophie , Schneeberger Pierre H. H. , Hattendorf Jan , Sayasone Somphou , Hürlimann Eveline , Keiser Jennifer 
Published: March 2024

BackgroundControl efforts of soil-transmitted helminthiases rely primarily on large scale administration of anthelminthic drugs. The assessment of drug efficacies and understanding of drug behavior is pivotal to the evaluation of treatment successes, both in preventive chemo-therapy programs as well as in research of novel treatment options. The current WHO guidelines recommend an interval of 14–21 days between the treatment and follow-up, yet no in-depth analysis of egg excretion patterns ofTrichuris trichiuraafter treatment has been conducted to date.MethodsWithin the framework of a multi-country trial to assess the efficacy and safety of albendazole-ivermectin combination therapy vs albendazole monotherapy againstT.trichiurainfections, we conducted a study collecting daily stool samples over the period of 28 days post-treatment in 87 participants in Pak Khan, Lao PDR. Egg counts were derived by duplicate Kato-Katz on-site forT.trichiura, hookworm andAscaris lumbricoidesand stool sample aliquots were subsequently analyzed by qPCR for the detection ofT.trichiurainfections. Sensitivity and specificity was calculated for each day separately using data derived by Kato-Katz to determine the optimal timepoint at which to assess drug efficacy.ResultsEgg excretion patterns varied across treatment arms. ForT.trichiura, only the albendazole-ivermectin treatment led to a considerable reduction in mean egg counts, whereas both treatments reduced hookworm egg counts andA.lumbricoideswere cleared in all participants after day 7. ForT.trichiura, we found sensitivity to be highest at days 18 and 22 when using egg counts as outcome and days 19 and 24 when using qPCR. Specificity was high (>0.9) from day 14 onwards. For hookworm, the highest sensitivity and specificity were found at days 17 and 25, respectively.ConclusionsBased on our study, the ideal time period to assess drug efficacy for soil-transmitted helminth infections would be between day 18 and 24. The current WHO recommendation of 14 to 21 days is likely to yield acceptable outcome measures for soil-transmitted helminth infections.Trial registrationNCT03527732.
Integration of two dual-port substrate integrated waveguide based MIMO antennas on a common substrate for 5G millimeter wave applications
Authors: Gorai Abhik , Panda Jyoti Ranjan , Bhowmik Wriddhi , Deb Arindam , Ghatak Rowdra 
Published: March 2024

Abstract
This paper presents method for integrating two dual port multiple input multiple output (MIMO) antennas on a common substrate based on substrate integrated waveguide (SIW) technology. One of the dual port MIMO antennas (MIMO_1) resonates at 31.2 GHz with an impedance bandwidth of 1 GHz while the other dual port MIMO antenna (MIMO_2) exhibits an impedance bandwidth of 925 MHz and resonates at 36 GHz. The radiators etched on the SIW cavities are complementary slotted annular rings (CSAR). Isolation between the ports is more than 20 dB which is inherently achieved by SIW cavity backed structures. The MIMO antenna realized at 31.2 GHz exhibit a peak realized gain of 8.5 dBi while the MIMO antenna realized at 36 GHz displays a peak gain of 9.8 dBi. The diversity gain of both the MIMO antennas is around 9.9 dB and the envelope correlation coefficient (ECC) of the MIMO antenna realized at 31 GHz is below 0.004 while the ECC of MIMO antenna at 36 GHz is below 0.006. It is also confirmed that simulated results closely correlate with the measurement results.
Three-dimensional finite-memory quasi-Newton inversion of the magnetotelluric based on unstructured grids
Authors: Song Huadong , Xue Yunfeng , Yan Chaoxu 
Published: March 2024

Abstract
Simulation optimization of complex geological bodies is a necessary means to improve inversion accuracy and computational efficiency; thus, inversion of magnetotelluric (MT) based on unstructured grids has become a research hotspot in recent years. This article realizes the three-dimensional (3D) finite element forward modeling of MT based on the magnetic vector potential-electric scalar potential method, using unstructured grids as the forward modeling grid, which improves computational efficiency. The inversion uses the limited-memory Broyden–Fletcher–Goldfarb–Shanno (LBFGS) method, and in the process of calculating the objective function gradient, the quasi-forward method is used to avoid solving the Jacobian matrix, which has the advantages of requiring small storage space and fast computational efficiency. Finally, the 3D LBFGS inversion algorithm of MT based on unstructured grids was realized, and the inversion studies of classic and complex models verified the effectiveness and the reliability of the algorithm proposed in this article.
Transmission line tower inclination measurement method based on three-dimensional laser scanning and inter frame difference
Authors: Yin Xiang , Guan Li , Wu Chaoqun , Zhang Ying , Tao Yuxin 
Published: March 2024

Abstract
The purpose of this study is to propose a method based on three-dimensional laser scanning and frame difference technology to measure the inclination of transmission line towers, so as to realize accurate monitoring of transmission line structure. Firstly, the multi-scale Retinex algorithm is used to enhance and preprocess the transmission line tower image to improve the image quality. Secondly, the method of frame difference and background difference is combined to detect and identify the inclined tower. Finally, the point cloud data of inclined tower is obtained by using three-dimensional laser scanning technology, and the inclination of transmission line tower is calculated by coordinates. The experimental results show that this method has high accuracy and reliability, with an error of less than 0.15 × 10−5 and an inclination of less than 0.17°. It is proved that this method can improve the monitoring efficiency of transmission lines, has good effects in engineering practice, and can provide effective means for the safe operation of transmission line structures.
An alternative view of the English alternative embedded passive
Authors: Duncan Daniel 
Published: March 2024

Abstract
The English alternative embedded passive (AEP), or “needs washed” construction, is a noncanonical morphosyntactic feature found in some American and British Englishes. It involves a matrix verb surfacing immediately before a participle. Previous research has described this construction as only licit with matrix need, want, and like; however, isolated examples of the AEP with additional matrix verbs have surfaced. These rarely attested instances raise questions regarding the basic description of the construction and how matrix verb availability is constrained, as well as whether the AEP is truly the same feature across AmE and BrE varieties. This paper utilizes a large-scale grammaticality judgement survey to obtain as exhaustive a set of AEP matrix verbs as possible. Results show that far more verbs can be used in the AEP than previously attested. Acceptance is constrained by lexical semantics, verbal syntax, and verb productivity. This alternative view of the AEP as a more generalized phenomenon nevertheless shows a strong link between AmE and BrE varieties, as the constraints are nearly identical across the nations. The findings illustrate how attention to rarely attested or non-attested data can inform morphosyntactic and dialectological research.
Influence of damage on large displacement buckling analysis of beams
Authors: Arcoraci Rosalinda , Fiore Ilaria , Greco Annalisa , Caliò Ivo 
Published: March 2024

Abstract
In this study, the influence of concentrated damage on the stability of beams under static loads is investigated according to a co-rotational-based large displacement approach. Well-known benchmark beam-like structures have been considered under different loading conditions and damage scenarios. The concentrated damage has been modelled by means of a cross section reduction of a beam element, following a strategy already adopted in the literature. The results have been expressed in terms of buckling loads and post-buckling responses for different damage scenarios associated with a concentrated damage characterized by different positions, intensities, and extensions.
The Portuguese pluperfect: diversity of forms, polysemy and interaction with adjuncts
Authors: Móia Telmo 
Published: March 2024

Abstract
This paper discusses the contemporary use of the Portuguese simple and two compound pluperfect forms (with the auxiliary verbs ter, and haver) of the indicative mood in written texts. Four topics are addressed. First, the claim that the simple pluperfect is currently a defective paradigm lacking the third person plural; this claim is confirmed and substantiated by looking at specific distinguishing contexts in corpora. Secondly, the competition between the three pluperfect forms, in written contemporary European and Brazilian Portuguese; it is shown that – contrary to some frequent comments in the literature – all three forms still have widespread usage, and occur in a relatively balanced way, in the type of registers considered (newspaper writing, modern literary texts, modern literary translations), in both varieties of the language. Thirdly, as regards semantic polyvalence, the possible existence of a deictic rather than anaphoric (temporal) pluperfect; it is argued that this type of pluperfect does indeed exist, and deserves separate grammatical recognition. Fourthly, the well-known cases of ambiguity in structures with pluperfect and temporal locating adjuncts, where the latter can act either as markers of the past perspective point required by the pluperfect, or as markers of the location time of the described eventualities; facts in English and Portuguese are compared, with some differences highlighted.
Bentuk dan Proses Penciptaan Tari Barong Wadon Karya Tantin Hermawati Di Sanggar Tondonegoro Kabupaten Pati
Authors: Alfarez Tommy Dwi , Putra Bintang Hanggoro 
Published: March 2024

Tari Barong Wadon merupakan tari kreasi yang diciptakan oleh Tantin Hermawati terinspirasi dari kesenian Barongan yang hidup dan berkembang di Kabupaten Pati. Sesuai dengan namanya, Tari Barong Wadon dimainkan oleh penari wanita tetapi gerak yang digunakan yaitu gerak gagahan dalam tari putra. Tujuan penelitian ini yaitu untuk mendeskripsikan bentuk tari dan menguraikan proses penciptaan tari Barong Wadon. Penelitian dilakukan dengan mengunakan metode kualitatif bersifat deskriptif dengan pendekatan etnokoreologi. Pengumpulan data menggunakan teknik observasi, wawancara, dan dokumentasi. Analisis data menggunakan teknik reduksi, penyajian, dan menyimpulkan data. Hasil penelitian menunjukkan bahwa Tari Barong Wadon merupakan tari kreasi yang proses penciptaannya mempertimbangkan aspek bentuk tari dan melalui tahapan koreografi meliputi tahap eksplorasi, improvisasi, dan komposisi. Bentuk tari Barong Wadon meliputi gerak, iringan, tema, tata busana, tata rias, properti, penari, dan tempat pertunjukan. Keunikan tari Barong Wadon selain ditarikan oleh penari perempuan yaitu memiliki karakter gerak perpaduan antara gerak gagahan dan gerak wanita yang memiliki karakter centil, serta memakai topeng Barongan sebagai properti sehingga memiliki daya tarik tersendiri.
Myricetin ameliorates polycystic ovary syndrome in mice by brown adipose tissue activation
Authors: Zheng Niuyi , Wang Chaolong , Li Yiqiu , Fu Haiying , Hu Tao 
Published: March 2024

In brief
Brown adipose tissue impaired in polycystic ovary syndrome (PCOS) plays a crucial role in the treatment of PCOS. This study shows that myricetin potently improves PCOS by activating brown adipose tissue (BAT).

Abstract
PCOS is a complex endocrine disease characterized by hyperandrogenism, anovulation and polycystic ovary, and is often accompanied by metabolic disorder such as insulin resistance. BAT has been considered as a promising target for the treatment of obesity and other metabolic disease. In this study, we showed that 3 weeks of myricetin (a compound from natural product) treatment improved metabolic capacity and insulin sensitivity by activating BAT in dehydroepiandrosterone (DHEA)-induced PCOS mice. Furthermore, increased number of corpus luteum and decreased cystic formation were observed in PCOS mice. With the hormone levels such as luteinizing hormone (LH) were reversed, estrous cycle was also normalized after myricetin treatment. Eventually, myricetin markedly improved reproductive defects in PCOS mice. In short, our results suggest that myricetin treatment dramatically ameliorates ovarian dysfunction and metabolic disturbances in PCOS and provides a novel perspective for the treatment of PCOS.
Marcin Selzer, a Jewish doctor from Lviv, and his contribution to combatting tuberculosis
Authors: Jakimyszyn-Gadocha Anna 
Published: March 2024

The objective of the paper is to discuss the actions to combat tuberculosis undertaken by Marcin Selzer (1876—1930), a medical doctor of a Jewish origin. Selzer worked in the National General Hospital in Lviv (today Lviv in Ukraine), and a sanatorium for TB patients in Hołosko and had also a private consultation room. He was engaged in the activities carried out by medical and aid societies, playing an active role in promoting the most recent methods of TB diagnosing and treatment. Doctor Selzer also had a contribution for the development of a sanatorium in Hołosko, improved a system of vacation trips for Jewish children and co-created a TB clinic for Jews in Lviv.