bluuebunny/crossref_metadata_2025_split huggingface dataset:
B cell pathway dual inhibition for systemic lupus erythematosus: a prospective single‐arm cohort study of telitacicept
Authors: Ji Lanlan , Geng Yan , Zhang Xiaohui , Deng Xuerong , Song Zhibo , Tan Meng , Tan Ying , Qu Chenxue , Zhang Zhuoli 
Published: March 2024

AbstractSystemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease associated with B‐cell hyperactivity. Telitacicept is a transmembrane activator, calcium modulator, and cyclophilin ligand interactor‐Fc fusion protein, which can neutralize both B‐cell lymphocyte stimulator and a proliferation‐inducing ligand. Patients with active SLE who received telitacicept were prospectively followed at month 1, 3, 6, 9, and 12 after telitacicept initiation. Thirty‐seven participants were involved and followed for 6.00 [3.00, 6.00] months. SRI‐4 rate at month 6 was 44.7%. The median dosage of prednisone was decreased by 43.8% (from 10 to 5.62 mg/d) at month 6. The anti‐dsDNA level was significantly decreased, while complement levels were significantly increased at month 6 from baseline. Continuously significant reductions in serum immunoglobin (Ig)G IgA, and IgM levels were also observed. Patients experienced significant decreases in the numbers of total and naive B cells, whereas memory B cells and T cell populations did not change. The number of NK cells was significantly increased during the follow‐up. At month 6, 58.3% (14 out of 24) patients experienced improved fatigue accessed by FACIT–Fatigue score exceeding the minimum clinically important difference of 4. Most adverse events were mild, but one each case of severe hypogammaglobulinemia, psychosis with suicidal behavior, and B‐cell lymphoma were occurred. In our first prospective real‐world study, telitacicept treatment led to a significant clinical and laboratory improvement of disease activity, as well as fatigue amelioration in patients with SLE. Safety profile was favorable overall, but more studies are greatly needed.
Clinical application of real‐time continuous glucose monitoring system during postoperative enteral nutrition therapy in esophageal cancer patients
Authors: Zhang Ranran , Wu Ying , Xv Rui , Wang Wei , Zhang Lei , Wang Ansheng , Li Min , Jiang Wei , Jin Guoxi , Hu Xiaolei 
Published: March 2024

AbstractBackgroundEnteral nutrition (EN) support therapy increases the risk of abnormal blood glucose (BG). The aim of this study is to evaluate the clinical value of a real‐time continuous glucose monitoring (rt‐CGM) system in BG monitoring during postoperative EN support therapy in patients with esophageal cancer.MethodsPatients without diabetes mellitus (DM) with esophageal cancer who planned to receive postoperative EN were enrolled. With the self‐monitoring of BG value as the reference BG, the accuracy of rt‐CGM was evaluated by the mean absolute relative difference (MARD) value, correlation efficient, agreement analysis, and Parkes and Clarke error grid plot. Finally, paired t tests were used to compare the differences in glucose fluctuations between EN and non‐EN days and slow and fast days.ResultsThe total MARD value of the rt‐CGM system was 13.53%. There was a high correlation between interstitial glucose and fingertip capillary BG (consistency correlation efficient = 0.884 [95% confidence interval, 0.874–0.894]). Results of 15/15%, 20/20%, 30/30% agreement analysis were 58.51%, 84.71%, and 99.65%, respectively. The Parkes and Clarke error grid showed that the proportion of the A and B regions were 100% and 99.94%, respectively. The glucose fluctuations on EN days vs non‐EN days and on fast days vs slow days were large, and the difference was statistically significant (P < 0.001).ConclusionThe rt‐CGM system achieved clinical accuracy and can be used as a new option for glucose monitoring during postoperative EN therapy. The magnitude of glucose fluctuation during EN therapy remains large, even in the postoperative population without DM.
Service utilization among adolescents seeking trauma‐related care: Differences by risk for suicide and ethnoracial background
Authors: Bravo Lilian G. , Ford Julian D. , Giscombe Cheryl Woods , Cooke Alison N. , Stein Gabriela Livas , Gonzalez‐Guarda Rosa M. , Jones Cheryl B. , Briggs Ernestine C. 
Published: March 2024

AbstractAdolescents from ethnoracially minoritized backgrounds increasingly report high rates of attempted suicide, trauma exposure, and limited access to mental healthcare services. However, less is known regarding their use of services across different youth‐serving systems. This study examines the associations and interactions between self‐injurious thoughts and behaviors (SITBs), race/ethnicity, and service sector utilization (mental healthcare, general healthcare, school, and social services) among a sample of trauma‐exposed and treatment‐seeking adolescents. Participants were treatment‐seeking adolescents (N = 4406) ages 12–17 from the National Child Traumatic Stress Network Core Data Set who had available data for SITBs, race/ethnicity, services utilized, and other key variables. Mixed effects logistic regression was used to examine main and interactive effects for whether adolescents' race/ethnicity and SITBs were associated with service utilization in each of the identified service sectors. SITBs were associated with adolescents' utilization of mental healthcare (OR = 1.38 p < 0.001), general healthcare (OR = 2.30; p < 0.001), and school services (OR = 1.38 p < 0.001). NH Black adolescents reporting SITBs were less likely to use mental health services than other NH Black youths (OR = 0.53; p = 0.004). Hispanic adolescents reporting SITBs were more likely to utilize healthcare services than other Hispanic youths (OR = 1.51; p = 0.039). Trauma‐exposed adolescents reporting SITBs are more likely to utilize mental healthcare, general healthcare, and school‐based services than other trauma‐exposed adolescents. However, NH Black adolescents experiencing SITBs may face additional barriers to utilizing mental healthcare services. Findings can be used to develop nursing practices and policies to address barriers faced by adolescents reporting SITBs.
Managers' perceptions of the factors affecting resident and patient safety work in residential settings and nursing homes: A qualitative systematic review
Authors: Kiljunen Outi , Savela Roosa‐Maria , Välimäki Tarja , Kankkunen Päivi 
Published: March 2024

AbstractIdentifying ways to ensure resident safety is increasingly becoming a priority in residential settings and nursing homes. The aim of this qualitative systematic review was to identify, describe, and assess research evidence on managers' perceptions regarding the barriers and facilitators of daily resident and patient safety work in residential settings and nursing homes. A qualitative systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis checklist. Published studies were sought through academic databases: Academic Search Premier, CINAHL, PubMed (MEDLINE), Scopus, SocINDEX, and Web of Science Core Collection in April 2023. Finally, 12 studies were included. The results of the included studies were synthesized using thematic synthesis after data extraction. According to the results, (1) competent staff and material resources; (2) management and culture; (3) communication, networks, optimal use of expertise; and (4) effective use of guidelines, rules, and regulations play a significant role in the success of resident and patient safety work. The findings revealed that promoting resident safety should not be seen solely as the responsibility of individual residential or nursing home personnel, as it requires multiprofessional cooperation and access to wider networks. Staff and managers must be receptive to learning, changing, and improving safety. Moreover, to ensure resident safety, it is essential to ensure that the organizations support safety work in residential and nursing home units.
Improving Health Literacy of Elective Procedures in Pediatric Otolaryngology
Authors: Del Risco Amanda , Cherches Alexander , Polcaro Lauren , Washabaugh Claire , Hales Robin , Jiang Rong , Allori Alexander , Raynor Eileen 
Published: March 2024

AbstractObjectiveTo identify if the addition of supplementary material, such as video or written resources, to the consent process, can improve a patient's or guardian's health literacy in pediatric otolaryngology.Study DesignProspective randomized crossover design.SettingTertiary Academic Center.MethodsFrom April 18, 2022 to August 29, 2023, 151 children scheduled to undergo 1 of 6 procedures by the same provider were queried and completed a 6‐question baseline test based on the information. They each watched a 2‐minute video and read a written summary about the procedure; the order of resources was randomized. They answered the same 6‐questions after viewing each resource. All tests were scored based on accuracy using an ordinal scale of 1 to 6. Resource preference was collected. Wilcoxon signed‐rank tests were run to analyze differences in scores after the addition of supplementary resources and logistic regression modeling was run to analyze demographic effects on postresource score differences.ResultsOf 151 participants, 74.2% were guardians, with 78.8% having completed a high school or greater education. The Wilcoxon signed‐rank test indicated that postresource scores were statistically significantly higher (P < .001) than pretest scores. Logistic regression modeling showed that participants were less likely to show score improved if they were younger than 18 and were of white race. A majority (87.4%) preferred the addition of a video to the consent process.ConclusionThe addition of video or written resources significantly improves understanding of elective procedures. The development of procedure‐specific resources can supplement the consent process and ensure decision‐makers have adequate health literacy for informed decision‐making.
Convolutional Neural Network‐Based Deep Learning Engine for Mastoidectomy Instrument Recognition and Movement Tracking
Authors: Raymond Mallory J. , Biswal Biswajit , Pipaliya Royal M. , Rowley Mark A. , Meyer Ted A. 
Published: March 2024

AbstractObjectiveTo develop a convolutional neural network‐based computer vision model to recognize and track 2 mastoidectomy surgical instruments—the drill and the suction‐irrigator—from intraoperative video recordings of mastoidectomies.Study DesignTechnological development and model validation.SettingAcademic center.MethodsTen 1‐minute videos of mastoidectomies done for cochlear implantation by varying levels of resident surgeons were collected. For each video, containing 900 frames, an open‐access computer vision annotation tool was used to annotate the drill and suction‐irrigator class images with bounding boxes. A mastoidectomy instrument tracking module, which extracts the center coordinates of bounding boxes, was developed using a feature pyramid network and layered with DETECTRON, an open‐access faster—region‐based convolutional neural network. Eight videos were used to train the model, and 2 videos were used for testing. Outcome measures included Intersection over Union (IoU) ratio, accuracy, and average precision.ResultsFor an IoU of 0.5, the mean average precision for the drill was 99% and 86% for the suction‐irrigator. The model proved capable of generating maps of drill and suction‐irrigator stroke direction and distance for the entirety of each video.ConclusionsThis computer vision model can identify and track the drill and suction‐irrigator from videos of intraoperative mastoidectomies performed by residents with excellent precision. It can now be employed to retrospectively study objective mastoidectomy measures of expert and resident surgeons, such as drill and suction‐irrigator stroke concentration, economy of motion, speed, and coordination, setting the stage for characterization of objective expectations for safe and efficient mastoidectomies.
A review of disease risk prediction methods and applications in the omics era
Authors: Sun Chen , Cheng Xiangshu , Xu Jing , Chen Haiyan , Tao Junxian , Dong Yu , Wei Siyu , Chen Rui , Meng Xin , Ma Yingnan , Tian Hongsheng , Guo Xuying , Bi Shuo , Zhang Chen , Kang Jingxuan , Zhang Mingming , Lv Hongchao , Shang Zhenwei , Lv Wenhua , Zhang Ruijie , Jiang Yongshuai 
Published: March 2024

AbstractRisk prediction and disease prevention are the innovative care challenges of the 21st century. Apart from freeing the individual from the pain of disease, it will lead to low medical costs for society. Until very recently, risk assessments have ushered in a new era with the emergence of omics technologies, including genomics, transcriptomics, epigenomics, proteomics, and so on, which potentially advance the ability of biomarkers to aid prediction models. While risk prediction has achieved great success, there are still some challenges and limitations. We reviewed the general process of omics‐based disease risk model construction and the applications in four typical diseases. Meanwhile, we highlighted the problems in current studies and explored the potential opportunities and challenges for future clinical practice.
The temporal protein signature analyses of developing human deciduous molar tooth germ
Authors: Chen Xiaohang , Li Gaochi , Zhang Jian , Hu Liang , Zhao Guoqiang , Wu Buling , Wei Fengxiang , Xiong Fu 
Published: March 2024

AbstractThe tooth serves as an exemplary model for developmental studies, encompassing epithelial‐mesenchymal transition and cell differentiation. The essential factors and pathways identified in tooth development will help understand the natural development process and the malformations of mineralized tissues such as skeleton. The time‐dependent proteomic changes were investigated through the proteomics of healthy human molars during embryonic stages, ranging from the cap‐to‐early bell stage. A comprehensive analysis revealed 713 differentially expressed proteins (DEPs) exhibiting five distinct temporal expression patterns. Through the application of weighted gene co‐expression network analysis (WGCNA), 24 potential driver proteins of tooth development were screened, including CHID1, RAP1GDS1, HAPLN3, AKAP12, WLS, GSS, DDAH1, CLSTN1, AFM, RBP1, AGO1, SET, HMGB2, HMGB1, ANP32A, SPON1, FREM1, C8B, PRPS2, FCHO2, PPP1R12A, GPALPP1, U2AF2, and RCC2. Then, the proteomics and transcriptomics expression patterns of these proteins were further compared, complemented by single‐cell RNA‐sequencing (scRNA‐seq). In summary, this study not only offers a wealth of information regarding the molecular intricacies of human embryonic epithelial and mesenchymal cell differentiation but also serves as an invaluable resource for future mechanistic inquiries into tooth development.
Iron regulatory protein from the hard tick Haemaphysalis longicornis: characterization, function and assessment as a protective antigen
Authors: Wang Duo , Zhang Xiaojing , Li Hongxia , Wang Ting , Ma Xiaojin , Yu Zhijun , Wang Fang , Zhang Yankai , Liu Jingze 
Published: March 2024

AbstractBACKGROUNDTicks are blood‐feeding ectoparasites with different host specificities and are capable of pathogen transmission. Iron regulatory proteins (IRPs) play crucial roles in iron homeostasis in vertebrates. However, their functions in ticks remain poorly understood. The aim of the present study was to investigate the characteristics, functions, molecular mechanisms, and the vaccine efficacy of IRP in the hard tick Haemaphysalis longicornis.RESULTSThe full‐length complementary DNA of IRP from Haemaphysalis longicornis (HlIRP) was 2973 bp, including a 2772 bp open reading frame. It is expressed throughout three developmental stages (larvae, nymphs, and adult females) and in various tissues (salivary glands, ovaries, midgut, and Malpighian tubules). Recombinant Haemaphysalis longicornis IRP (rHlIRP) was obtained via a prokaryotic expression system and exhibited aconitase, iron chelation, radical‐scavenging, and hemolytic activities in vitro. RNA interference‐mediated IRP knockdown reduced tick engorgement weight, ovary weight, egg mass weight, egg hatching rate, and ovary vitellin content, as well as prolonging the egg incubation period. Proteomics revealed that IRP may affect tick reproduction and development through proteasome pathway‐associated, ribosomal, reproduction‐related, and iron metabolism‐related proteins. A trial on rabbits against adult Haemaphysalis longicornis infestation demonstrated that rHlIRP vaccine could significantly decrease engorged weight (by 10%), egg mass weight (by 16%) and eggs hatching rate (by 22%) of ticks. The overall immunization efficacy using rHlIRP against adult females was 41%.CONCLUSIONIRP could limit reproduction and development in Haemaphysalis longicornis, and HlIRP was confirmed as a candidate vaccine antigen to impair tick iron metabolism and protect the host against tick infestation. © 2024 Society of Chemical Industry.
The first extensive analysis of species composition and abundance of stink bugs (Hemiptera: Pentatomidae) on soybean crops in Brazil
Authors: Saldanha Alan Valdir , Horikoshi Renato , Dourado Patrick , Lopez‐Ovejero Ramiro Fernando , Berger Geraldo U. , Martinelli Samuel , Head Graham P. , Moraes Tamara , Corrêa Alberto Soares , Schwertner Cristiano Feldens 
Published: March 2024

AbstractBACKGROUNDSoybean is the third‐greatest global commodity crop with respect to grain production, Brazil is the largest soybean producer in the world. We performed the first extensive survey including all the five main soybean cultivation regions in Brazil over three seasons (2018/2019, 2019/2020, and 2020/2021). A total of 2386 localities were sampled, corresponding to 145 municipalities in 11 states. Sampling was carried out between the R1 and R8 soybean growth stages, using a beating sheet.RESULTSFifteen species were recorded, with five species accounting for more than 99% of the sampled insects. The Neotropical brown stink bug, Euschistus heros (F.), was the most abundant species (82.4% of the adults and 84.1% of the nymphs overall), with differences in the mean abundance between soybean macroregions. The melacanthus green belly stink bug, Diceraeus melacanthus Dallas was the second most abundant species overall, followed by the brown winged stink bug, Edessa meditabunda (F.), the furcatus green belly stink bug, Diceraeus furcatus (F.) and the red‐banded green stink bug, Piezodorus guildinii (Westwood). The relative abundance of each species differed between soybean macroregions. The mean abundance of nymphs and adults of Euschistus heros at different soybean reproductive stages showed an increase from early reproductive stages to the beginning of the late reproductive stages (R5 or R6).CONCLUSIONThis large‐scale assessment of stink bugs provides a basis for outlining integrated pest management programs and drives the development of monitoring and control strategies, as well as future studies investigating population dynamics over time and space in soybean fields. © 2024 Society of Chemical Industry.
Reliability assessment of man‐machine systems subject to probabilistic common cause errors
Authors: Li Kehui , Guo Jianbin , Zeng Shengkui , Che Haiyang 
Published: March 2024

AbstractThe occurrence of probabilistic common cause errors (PCCEs) in man‐machine systems can lead to multiple human errors being affected by common causes and will contribute greatly to the reliability of the system. In this paper, A reliability modeling method based on event tree (ET)‐fault tree (FT) model for man‐machine systems subjected to PCCEs is proposed. Under the influence of PCCEs, risk factors in the system are not independent, and human errors affected by the same common cause will occur with different probabilities. To describe the dependencies among risk factors, a PCCE gate is proposed to extend FTs in the ET‐FT model. To analyze the impact of common causes on the human error probabilities and quantify the extended FT, an explicit method and an implicit method based on the Cognitive Reliability and Error Analysis Method are proposed. The proposed quantification methods consider the different relationships among multiple common causes in a single model. Finally, the proposed methods are validated in the reliability assessment of the emergency response system under malfunction of the solar wing mechanism.
A case report of Birt–Hogg–Dubé syndrome associated with severe airway obstruction in a 62‐year‐old female smoker
Authors: Uemasu Kiyoshi , Nyunoya Toru 
Published: March 2024

AbstractBirt–Hogg–Dubé syndrome (BHD) typically does not manifest airway obstruction despite the presence of multiple lung cysts. However, the long‐term effects of cigarette smoking on lung function among individuals with BHD are unknown. We report a case of a smoking individual diagnosed with BHD syndrome complicated by spontaneous pneumothorax and severe airway obstruction. The patient presented with chronic dyspnea and productive cough. Further work‐up revealed severe obstructive airflow limitation, and multiple lung cysts in both lungs, accompanied centrilobular emphysematous changes. Genetic testing confirmed a heterozygous deletion of exons 6–8 in the folliculin gene, confirming the diagnosis of BHD.
High–Quality and Stable Quasi‐2D Perovskite Film Prepared by Introducing Alkali Metal Ion Additive
Authors: Gong Ying , Zhou Jinxiao , Qu Qianqian , Wang Jinxi , Liu Huijin , Wang Hanying , Xi Xiaoyan , Bi Shiqing 
Published: March 2024

AbstractDue to the excellent stability, researchers have shown great interest in quasi two–dimensional (2D) perovskite in recent years. However, the poor film quality and low photoelectric conversion efficiency (PCE) of 2D perovskite solar cells are still a major issue that restricts them from catching up with three–dimensional (3D) perovskite. Herein, we introduce sodium iodide as an additive to improve the surface coverage of 2D perovskite ((BA)2(MA)3Pb4I13) films and reduce the number of grain boundaries. Steady–state photoluminescence (PL) and ultraviolet photoelectron spectroscopy (UPS) indicate that non–radiative defects are suppressed and the band alignment is regulated. After modified by NaI, the film surface coverage enhances and the number of holes decreases. As a result, the PCE of device with NaI increases from 13.63 % to 16.40 % at optimal concentration, and the hysteresis effect is also suppressed. Besides, the humidity and thermal stability of perovskite are enhanced. The device with NaI modification can keep 80 % of initial efficiency, compared to 30 % for reference device after stored 30 days under ambient air condition. This work provides a simple method to improve the quality of quasi 2D perovskite films.
Synthesis of an Amine Moiety‐Based Fluorescent Probe and the Relationship Between the Amino Substitution Position and Formaldehyde Detection Performance
Authors: Tan Xi‐zhe , Hua Meng‐yao , Wang Si‐yi , Xu Lei , Zhang Guo‐fang , Gou Xing‐long 
Published: March 2024

AbstractA novel amine moiety‐based fluorescent probe (BA) was prepared using diphenylacetylene as fluorophore and amino group as acceptor. The probe achieves detection of formaldehyde through fluorescence enhancement by inhibition the photoinduced electron transfer (PET) between diphenylacetylene and amino group. And the different formaldehyde detection performance of 2‐(phenylethynyl)aniline (BA‐1), 3‐(phenylethynyl)aniline (BA‐2) and 4‐(phenylethynyl)aniline (BA‐3) indicates that the position of amino recognition group on the benzene ring of diphenylacetylene has a significant impact on the detection ability of this type fluorescent probe. When the amino group is in the ortho‐position of the benzene ring, probe BA‐1 can rapidly enhance the fluorescence intensity within 20 min with limit of detection as low as 0.75 μM; When the amino group is located in meta‐position of benzene ring, the solution of BA‐2 also exhibited a certain degree of fluorescence enhancement, but it is weaker than BA‐1; When the amino group is at the para‐position of benzene ring, BA‐3 has almost no response to formaldehyde.