bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuroprotective effect of Withania somnifera leaves extract nanoemulsion against penconazole-induced neurotoxicity in albino rats via modulating TGF-β1/Smad2 signaling pathway
Authors: Abomosallam Mohamed , Hendam Basma M. , Abdallah Amr A. , Refaat Rasha , EL-Hak Heba Nageh Gad 
Published: April 2024

AbstractPenconazole (PEN) is a systemic triazole fungicide used to control various fungal diseases on grapes, stone fruits, cucurbits, and strawberries. Still, it leaves residues on treated crops after collection with many hazardous effects on population including neurotoxicity. Withania somnifera leaves extract (WSLE) is known for its memory and brain function enhancing ability. To evoke such action efficiently, WSLE bioactive metabolites are needed to cross the blood–brain barrier, that could limit the availability of such compounds to be localized within the brain. Therefore, in the present study, the association between PEN exposure and neurotoxicity was evaluated, and formulated WSLE nanoemulsion was investigated for improving the permeability of the plant extract across the blood–brain barrier. The rats were divided into five groups (n = 6). The control group was administered distilled water, group II was treated with W. somnifera leaves extract nanoemulsion (WSLE NE), group III received PEN, group IV received PEN and WSLE, and group V received PEN and WSLE NE. All rats were gavaged daily for 6 weeks. Characterization of compounds in WSLE using LC–MS/MS analysis was estimated. Neurobehavioral disorders were evaluated in all groups. Oxidative stress biomarkers, antioxidant enzyme activities, and inflammatory cytokines were measured in brain tissue. Furthermore, the gene expression patterns of GFAP, APP, vimentin, TGF-β1, Smad2 and Bax were measured. Histopathological changes and immunohistochemical expression in the peripheral sciatic nerve and cerebral cortex were evaluated. A total of 91 compounds of different chemo-types were detected and identified in WSLE in both ionization modes. Our data showed behavioral impairment in the PEN-treated group, with significant elevation of oxidative stress biomarkers, proinflammatory cytokines, neuronal damage, and apoptosis. In contrast, the PEN-treated group with WSLE NE showed marked improvement in behavioral performance and histopathological alteration with a significant increase in antioxidant enzyme activity and anti-inflammatory cytokines compared to the group administered WSLE alone. The PEN-treated group with WSLE NE in turn significantly downregulated the expression levels of GFAP, APP, vimentin, TGF-β1, Smad2 and Bax in brain tissue. In conclusion, WSLE NE markedly enhanced the permeability of plant extract constituents through the blood brain barrier to boost its neuroprotective effect against PEN-induced neurotoxicity.
Following Schubert varieties under Feigin’s degeneration of the flag variety
Authors: Bossinger Lara , Lanini Martina 
Published: April 2024

AbstractWe study the effect of Feigin’s flat degeneration of the type $$\text {A}$$
A
flag variety on the defining ideals of its Schubert varieties. In particular, we describe two classes of Schubert varieties which stay irreducible under the degenerations and in several cases we are able to encode reducibility of the degenerations in terms of symmetric group combinatorics. As a side result, we obtain an identification of some degenerate Schubert varieties (i.e. the vanishing sets of initial ideals of the ideals of Schubert varieties with respect to Feigin’s Gröbner degeneration) with Richardson varieties in higher rank partial flag varieties.
Human Research Ethics Review Challenges in the Social Sciences: A Case for Review
Authors: Macnamara Jim 
Published: April 2024

AbstractEthical conduct is a maxim in scholarly research as well as scholarly endeavour generally. In the case of research involving humans, few if any question the necessity for ethics approval of procedures by ethics boards or committees. However, concerns have been raised about the appropriateness of ethics approval processes for social science research arguing that the orientation of ethics boards and committees to biomedical and experimental scientific research, institutional risk aversion, and other factors lead to over-protection of research participants and overly restrictive processes that delay and sometimes prevent important social science research. This is particularly significant when social science research is required to respond to social, environmental, or health emergencies and in contract research projects for the reasons explained. This analysis of an ethics approval case study adds to increasing concerns that ethics approval processes can have perverse effects in the social sciences. While a single case study does not provide generalizable findings, in-depth analysis of a significant case can identify issues that need to be further explored. Recommendations offer pathways for facilitating social science research including in emergency situations in which timeliness is important and in collaborative approaches such as participatory action research, while maintaining high ethical standards.
From UK-2A to florylpicoxamid: Active learning to identify a mimic of a macrocyclic natural product
Authors: Cleves Ann E. , Jain Ajay N. , Demeter David A. , Buchan Zachary A. , Wilmot Jeremy , Hancock Erin N. 
Published: April 2024

AbstractScaffold replacement as part of an optimization process that requires maintenance of potency, desirable biodistribution, metabolic stability, and considerations of synthesis at very large scale is a complex challenge. Here, we consider a set of over 1000 time-stamped compounds, beginning with a macrocyclic natural-product lead and ending with a broad-spectrum crop anti-fungal. We demonstrate the application of the QuanSA 3D-QSAR method employing an active learning procedure that combines two types of molecular selection. The first identifies compounds predicted to be most active of those most likely to be well-covered by the model. The second identifies compounds predicted to be most informative based on exhibiting low predicted activity but showing high 3D similarity to a highly active nearest-neighbor training molecule. Beginning with just 100 compounds, using a deterministic and automatic procedure, five rounds of 20-compound selection and model refinement identifies the binding metabolic form of florylpicoxamid. We show how iterative refinement broadens the domain of applicability of the successive models while also enhancing predictive accuracy. We also demonstrate how a simple method requiring very sparse data can be used to generate relevant ideas for synthetic candidates.
The output performance evaluations of multilayered piezoelectric nanogenerators based on the PVDF-HFP/PMN-35PT using various layer-by-layer assembly techniques
Authors: Paralı Levent 
Published: April 2024

AbstractMultilayered Poly (vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) and lead magnesium niobate lead titanate Pb (Mg1/3Nb2/3) O3–PbTiO3 (PMN-35PT) composition-based piezoelectric nanogenerators (PNGs) were fabricated as series, parallel, and combined series-parallel connections using various layer-by-layer assembly techniques. Supporting the theoretical approaches with experimental results shows that the fabricated four-layered PNG with parallel connections (4L-P) reached an open-circuit voltage of 0.4 V (VRMS) and a maximum electrical power of 0.3 µW (PRMS) by drawing a current (IRMS) of 1.46 µA under a resistive load of 140.2 KΩ. Increasing the capacitance and decreasing the impedance with the fabrication of the four-layer PNG by connecting the layers in parallel connection with the support of the impedance matching process led to an increase in electrical output. With the use of an impedance matching system, the piezoelectric performance tests revealed that the 4L-P-based PNG had a 6.7 times greater electrical power efficiency (72.92 µW) at the vibrational frequency of 20 Hz compared to that of the single-layered PNG (10.82 µW). Furthermore, the multilayer PNG was successfully used as a wearable sensor for the monitoring of human body motions in real time on an IOT (Internet of Things) platform.
160 Gbps MMF/FSO system based on OAM beams and PV code under rainy weather
Authors: Abd El-Mottaleb Somia A. , Singh Mehtab , Aly Moustafa H. 
Published: April 2024

AbstractIn this paper, a high-speed transmission system that combines a multimode fiber (MMF) with Free Space Optics (FSO) is proposed to accommodate the rapid growth of traffic. As Orbital Angular Beams Multiplexing (OAM) plays a crucial role in 6G networks by enhancing transmission capacity, four OAM beams ($${LG}_{\mathrm{0,0}}$$LG0,0,$${LG}_{\mathrm{0,20}}$$LG0,20,$${LG}_{\mathrm{0,40}}$$LG0,40, and$${LG}_{\mathrm{0,40}}$$LG0,40) are utilized in this study. Additionally, the Optical Code Division Multiple Access (OCDMA) technique is employed, known for its high level of confidentiality and the ability to allow multiple channels to transmit data simultaneously. To ensure ubiquitous data transmission, two channels: MMF and FSO are used. Accordingly, in our proposed MMF/FSO system, we employ four OAM beams, with each carrying four OCDMA channels assigned distinct Permutation Vector (PV) codes. With a data transmission rate of 10 Gbps on each OCDMA channel, the overall capacity of the system amounts to 160 Gbps (10 Gbps × 4 OCDMA channels × 4 OAM beams). Moreover, the performance is investigated and evaluated using two scenarios. The first assumes an FSO range of 5 km and Clear Air (CA) weather conditions, with a variable MMF length. In contrast, the second scenario maintains a fixed MMF length of 1 km while altering the FSO span. Weather conditions like CA and rain conditions; Light Rain (LR), Medium Rain (MR), and Heavy Rain (HR) are considered while evaluating the system performance in the second case. The bit error rate (BER), travelling distances in the channel either MMF or FSO, and eye diagrams are among the metrics used for evaluation. They all provide information about the received signal performance. Finally, the obtained results for the proposed MMF/FSO system, utilizing OAM beams and PV codes, indicate that in the first scenario, the system can support a total capacity of 160 Gbps across all channels. The performance is noteworthy, with a BER below$${10}^{-5}$$10-5and a wide eye opening, enabling successful transmission over 6.2 km (1.2 km MMF length + fixed 5 km FSO span). For the second scenario, the achievable distance is decreased due to the attenuation caused by rain. It becomes 2.62 km (1 km MMF + 1.62 km FSO span), 5.2 km (1 km MMF + 1.2 km FSO span), and 1.77 km (1 km MMF + 0.77 km FSO span), under LR, MR, and HR, respectively.
A generalized nonlinear Schrödinger equation with logarithmic nonlinearity and its Gaussian solitary wave
Authors: Hosseini K. , Alizadeh F. , Hinçal E. , Kaymakamzade B. , Dehingia K. , Osman M. S. 
Published: April 2024

AbstractIn the current paper, a generalized nonlinear Schrödinger (gNLS) equation with logarithmic nonlinearity is studied as a model for the propagation of optical pulses. More precisely, after applying a specific hypothesis for the solution of the governing equation, its Gaussian solitary wave is retrieved using the ansatz method. Some numerical simulations in two- and three-dimensional postures are presented to investigate the impact of different physical parameters on Gaussian solitary wave’ dynamics. Results confirm that the physical parameters of the gNLS equation have a key role in controlling the dynamics of the Gaussian solitary wave.
Paying attention: the neurocognition of archery, Middle Stone Age bow hunting, and the shaping of the sapient mind
Authors: Lombard Marlize 
Published: April 2024

AbstractWith this contribution I explore the relationship between attention development in modern archers and attention as a cognitive requirement for ancient bow hunting – a techno-behaviour that may have originated sometime between 80 and 60 thousand years ago in sub-Saharan Africa. Material Engagement Theory serves as a framework for the inextricable interrelatedness between brain, body and mind, and how practicing to use bimanual technologies shapes aspects of our cognition, including our ability to pay attention. In a cross-disciplinary approach, I use cognitive-motor neuroscience to demonstrate the role of attention in modern archery and highlight brain regions that are activated or ‘pressured’ during aiming with attention. One of these areas, the precuneus together with the default mode network, serves as neurological hub for accurate bimanual material engagement practiced over a distance. The likely development of the precuneus, in tandem with the unique globularisation of the human skull, can be traced in theHomo sapiensfossil record since about 160 thousand years ago, reaching the modern range by around 100 thousand years ago within a continuum of brain modification. Variation in human neuro-genetic adaptations since our split from the Denisovan and Neanderthal groups further suggest differences in attention as a cognitive trait between recent big-brained humans. I suggest that these observations may serve as bridging theory for understanding how some aspects of the sapient ability to pay attention was developed.
Need help blurring the boundaries of your process archaeology? Don’t use agential realism. Try playing with clay
Authors: March Paul Louis 
Published: April 2024

AbstractOver the last twenty years, archaeologists have used various process-oriented modes of enquiry to undermine the belief that humans are special. Barad (2007) developed Bohr’s indeterminist interpretation of quantum mechanics into agential realism which offers an ontological basis for distributing agency away from humans and plays a crucial role in underwriting some posthumanist archaeological agendas. But its origins in quantum physics make agential realism difficult to understand and evaluate. Despite the challenge, the first two parts of this paper are devoted to each task in turn, with limited success. Part three turns to the archaeological literature, where the evaluation of agential realism turns out to be even more inadequate and so I advise against its use in support of process-oriented approaches in archaeology. The final section turns to the activity of an art workshop and introduces a playful approach to working with clay. Clayful phenomenology is a way of investigating the relationship between gesture, material and ideation. During sculpting, phenomenological experience is not subjective, stable and external but is generated within a transient creative system where entities, ideas and agency reciprocally, emerge as ephemeral manifestations. Clayful phenomenology and agential realism are ontologically similar and both are controversial but agential realism has a wall of quantum conceptual complexity standing between it and a judgement about credibility whereas playing with clay can be assessed directly, through experience.
GATA transcription factor in common bean: A comprehensive genome-wide functional characterization, identification, and abiotic stress response evaluation
Authors: Abdulla Mohamed Farah , Mostafa Karam , Aydin Abdullah , Kavas Musa , Aksoy Emre 
Published: April 2024

AbstractThe GATA transcription factors (TFs) have been extensively studied for its regulatory role in various biological processes in many plant species. The functional and molecular mechanism of GATA TFs in regulating tolerance to abiotic stress has not yet been studied in the common bean. This study analyzed the functional identity of the GATA gene family in the P. vulgaris genome under different abiotic and phytohormonal stress. The GATA gene family was systematically investigated in the P. vulgaris genome, and 31 PvGATA TFs were identified. The study found that 18 out of 31 PvGATA genes had undergone duplication events, emphasizing the role of gene duplication in GATA gene expansion. All the PvGATA genes were classified into four significant subfamilies, with 8, 3, 6, and 13 members in each subfamily (subfamilies I, II, III, and IV), respectively. All PvGATA protein sequences contained a single GATA domain, but subfamily II members had additional domains such as CCT and tify. A total of 799 promoter cis-regulatory elements (CREs) were predicted in the PvGATAs. Additionally, we used qRT-PCR to investigate the expression profiles of five PvGATA genes in the common bean roots under abiotic conditions. The results suggest that PvGATA01/10/25/28 may play crucial roles in regulating plant resistance against salt and drought stress and may be involved in phytohormone-mediated stress signaling pathways. PvGATA28 was selected for overexpression and cloned into N. benthamiana using Agrobacterium-mediated transformation. Transgenic lines were subjected to abiotic stress, and results showed a significant tolerance of transgenic lines to stress conditions compared to wild-type counterparts. The seed germination assay suggested an extended dormancy of transgenic lines compared to wild-type lines. This study provides a comprehensive analysis of the PvGATA gene family, which can serve as a foundation for future research on the function of GATA TFs in abiotic stress tolerance in common bean plants.
A field- and time-normalized Bayesian approach to measuring the impact of a publication
Authors: Gómez–Déniz Emilio , Dorta–González Pablo 
Published: April 2024

AbstractMeasuring the impact of a publication in a fair way is a significant challenge in bibliometrics, as it must not introduce biases between fields and should enable comparison of the impact of publications from different years. In this paper, we propose a Bayesian approach to tackle this problem, motivated by empirical data demonstrating heterogeneity in citation distributions. The approach uses the a priori distribution of citations in each field to estimate the expected a posteriori distribution in that field. This distribution is then employed to normalize the citations received by a publication in that field. Our main contribution is the Bayesian Impact Score, a measure of the impact of a publication. This score is increasing and concave with the number of citations received and decreasing and convex with the age of the publication. This means that the marginal score of an additional citation decreases as the cumulative number of citations increases and increases as the time since publication of the document grows. Finally, we present an empirical application of our approach in eight subject categories using the Scopus database and a comparison with the normalized impact indicator Field Citation Ratio from the Dimensions AI database.
Lurking Glares. A Comparative Critique of Latency and Cryptotypes
Authors: Costantini Cristina 
Published: April 2024

AbstractBased on Rodolfo Sacco’s passionate research on cryptotypes and mute law, the essay aims to propose an onto-aesthetic understanding of latency in law. Inspired by a transdisciplinary way of thinking, the Author elevates comparative law to the privileged site where a critique of the unexpressed can be performed; the degree of figurality of the law can be uncovered and measured; an economy of surplus can be disclosed as the proper segnatorial trait of the material appearances of the law. In this direction, comparative law combines a phenomenology of latency with a hermeneutics of the implicit/implied and becomes the place where it is possible to uncover the communality among plural symbolic universes (literature, arts, music) against the tyranny of disciplinary strategy.
Perceptual occlusion and the differentiation condition
Authors: Overgaard Søren 
Published: April 2024

AbstractNumerous philosophers accept the differentiation condition, according to which one does not see an object unless one visually differentiates it from its immediate surroundings. This paper, however, sounds a sceptical note. Based on suggestions by Dretske (2007) and Gibson (2002 [1972]), I articulate two ‘principles of occlusion’ and argue that each principle admits of a reading on which it is both plausible and incompatible with the differentiation condition. To resolve the inconsistency, I suggest we abandon the differentiation condition.
Does obstructive sleep apnea–induced intermittent hypoxia increase the incidence of solitary pulmonary nodules, thyroid nodules, and other disorders? A retrospective study based on 750 cardiovascular disease patients
Authors: Ding Chen , Mao Libo , Lu Yinghong , Wu Sai , Ji Wenyan 
Published: April 2024

Abstract
Background
Obstructive sleep apnea (OSA) has been shown to be an important risk factor for cardiovascular disease (CVD), and intermittent hypoxia is an important pathogenetic factor for it. In the clinic, it was found that most CVD patients combined with OSA were also combined with solitary pulmonary nodules (SPN) or thyroid nodules (TN). Are these disorders related to intermittent hypoxia? One study showed that intermittent hypoxia is a pathogenic factor for lung cancer in mice, but there have been no clinical reports. So we conducted a retrospective study to explore whether intermittent hypoxia caused by OSA increases the incidence of SPN, TN, and other disorders.

Methods
We selected 750 patients with cardiovascular disease (CVD), who were divided into the control group and the OSA group according to the result of portable sleep monitoring. Retrospectively analyzed the comorbidities that patients with OSA are prone to and explored the correlation between OSA and those comorbidities.

Results
The incidence of SPN, TN, cervical spondylosis, and carotid-artery plaques was higher in the OSA group than in the control group. These diseases are significantly associated with OSA (p < 0.05), and their incidence increased with an elevated apnea–hypopnea index. After excluding interference from age, gender, BMI, smoking history, history of lung disease, and history of tumors, OSA showed a significant correlation with SPN. After excluding age, gender, BMI, and thyroid disease, OSA was associated with TN. Patients with comorbidities have lower nocturnal oxygen saturation and more extended periods of apnea. Logistic multiple regression results revealed that male, advanced age, obesity, CS, and nasal septum deviation were independent risk factors for OSA.

Conclusions
Patients combined with OSA may further develop more comorbidities, such as SPN, TN, and carotid-artery plaques. It may be related to intermittent hypoxia caused by OSA.