bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute histological reactions in the otolith organs to inner ear drug delivery through a cochlear implant
Authors: Manrique-Huarte Raquel , Álvarez de Linera-Alperi Marta , Pérez-Fernández Nicolás , Manrique Manuel 
Published: February 2024

IntroductionCochlear implantation is currently regarded as a safe and minimally invasive procedure. However, cochlear implantation can have an impact on vestibular function, despite the lack of correlation between patient symptomatology and damage in vestibular tests. Thus, the present study aims to analyze the presence of hydrops and histological reactions at the level of the vestibule after cochlear implantation with dexamethasone pump delivery in Macaca fascicularis (Mf).Materials and methodsA detailed histological study was conducted on a total of 11 Mf. All 11 Mf were divided into three groups: 5 Mf were implanted with an electrode array HL-14 connected to a pump delivering FITC-dextran for 24 h (Group A); 4 Mf were implanted with a CI electrode array attached to a pump for FITC-dextran delivery for 7 days (Group B); and 2 Mf were considered the control group, without any kind of cochlear device implantation (Group C). After drug deliver, the selected macaques were euthanized to collect tissue samples for histological analysis. An experienced observer, focusing on the utricle and saccule areas, conducted a blinded inner ear histology analysis.ResultsSurgical procedures were successfully performed in all cases. No signs of cochlear reaction to the device were observed, including neither collapse nor fibrosis. Endolymphatic sinus dilatation was observed in Mf4A and Mf3B, while cochlear hydrops was observed in Mf3A. The mean areas of the utricle and saccule exhibited some statistically significant differences, specifically, in the saccule between groups C and both groups A (p = 0.028) and B (p = 0.029); however, no significant differences were observed between groups A and B or among comparisons of the utricle.DiscussionA significant concern relates to the safety of cochlear implantation with regard to vestibular preservation and hearing. New advancements in electrode arrays, such as CI devices coupled with delivery pumps, pose a challenge in maintaining minimally traumatic surgical concept-based procedures without affecting the inner ear homeostasis. The implantation of this device may cause vestibular hydrops in the saccule, indicating that the longer the time of substance release, the greater the grade of hydrops evidenced at the saccular level. Apart from this finding, the risk of histological damage to the vestibule is low.
Design of optical fiber delay line with large delay range and low insertion loss
Authors: Wang Kai , Liu Anqi , Kong Xinxin , Wu Zhou , Zhang Rui , Zhang Wenxi 
Published: February 2024

For the application of continuously adjustable optical fiber delay lines, a large delay range can increase the instrument’s measurement range. Increased insertion loss of components will reduce the signal-to-noise ratio of the collected signal, ultimately limiting the measurement accuracy of the instrument. In order to take into account both large delay range and low insertion loss in design, a spatial light transmission and fiber coupling model based on scalar diffraction theory was established and the insertion loss was equivalently calculated through the coupling efficiency of the coupling lens. Then, we analyze the impact of optical fiber delay line’s structural parameters and adjustment errors on coupling efficiency. By optimizing lens group parameters and limiting adjustment tolerances, we can reduce the insertion loss of optical fiber delay lines in a large delay range and conduct experimental verification. Considering various influencing factors, we use a lens group with a focal length of 12 mm, achieving a coupling efficiency of no less than 92.7% within the delay range of 0–1 m. This theoretical model provides a new quantitative analysis method for improving the performance of the optical fiber delay line.
Mobile-based ecological momentary assessment and intervention: bibliometric analysis
Authors: Yin Hongfan , Zhu Hanjing , Gu Jia , Qin Hengwei , Ding Wenjing , Guo Ningyuan , Fu Jingjing , Yang Yan 
Published: February 2024

ObjectiveThe aim of this article was to review existing documents in the field of mobile-based EMA and EMI, provide an overview of current hot topics, and predict future development trends.MethodsWe conducted a bibliometric study on mobile-based EMA and EMI publications that were collected from the Web of Science Core Collection database. Biblioshiny and CiteSpace were utilized to analyze scientific productions, leading sources, authors, affiliations, documents, research hot topics, keywords, and trend topics.ResultsA total of 2222 documents related to EMA and EMI published between 1992 and 2023 were retrieved. In recent years, scholarly publications have generally increased in mobile-based EMA and EMI research, particularly in the last decade. JMIR mHealth and uHealth (n=86), as well as JMIR (n=73), showed the highest number of publications. The United States (n=1038), Germany (n=218) and Netherlands (n=175) were leading countries. Regarding keyword co-occurrence and trend topics analysis, mental health, health behaviors, and feasibility were hot topics in mobile-based EMA and EMI research. Future research trends included using EMA for tailoring EMI, just-in-time adaptive interventions (JITAI), and digital phenotyping.ConclusionThis bibliometric study on mobile-based EMA and EMI is a valuable resource for understanding the field’s evolution and future trends. Our analysis indicates that EMA and EMI have great potential in health behaviors and mental health, but implementation should consider feasibility and reactivity issues carefully. Emerging trends include EMA-tailored EMI, JITAI, and digital phenotyping. In the future, strengthening multidisciplinary cooperation will be necessary to promote the continued development of the field.
Treatment of patients with anorexia nervosa and comorbid post-traumatic stress disorder; where do we stand? A systematic scoping review
Authors: van den Berg Elske , Pellemans Kirsten , Planting Caroline , Daansen Peter , van Beers Ella , de Jonge Margo , Christ Carolien , Dekker Jack 
Published: February 2024

ObjectiveComorbid post-traumatic stress disorder in patients with anorexia nervosa may negatively affect the course of anorexia nervosa treatment, which is already challenging. There are currently no guidelines or recommendations on concurrent treatment approaches for both anorexia nervosa and post-traumatic stress disorder. This systematic scoping review aims to explore the feasibility, acceptability and effectiveness of psychological trauma-focused treatment concurrently offered to underweight patients receiving anorexia nervosa treatment.MethodA multi-step literature search, according to an a priori protocol was performed. Databases PubMed, Embase, APA PsycINFO, Web of Science, Scopus and Cochrane Central were searched up to September 19th 2022, and the search was rerun June 19th 2023. For quality assessment, Risk of Bias in Non-randomised Studies-of Interventions tool was used.ResultsThe extensive search yielded 1769 reports, out of which only three observational pilot studies, both English and German, published between 2004 and 2022, could be included. The included studies reported on a total of 13 female participants between 16 and 58 years old, with anorexia nervosa or otherwise specified feeding or eating disorder, baseline BMI ranging between 14.6 and 16.5, who received concurrent anorexia and post-traumatic stress disorder treatment. In all participants, the emotional and cognitive functioning was sufficient to process the offered trauma-focused interventions, despite their significantly low body weight.DiscussionThe findings of this review identify a dearth of treatment research on knowledge of concurrent trauma-focused treatments for patients with anorexia nervosa. Refraining patients with anorexia nervosa from trauma-focused treatment may not be warranted.
Social support, educational, and behavioral modification interventions for improving household disaster preparedness in the general community-dwelling population: a systematic review and meta-analysis
Authors: Amberson Taryn , Heagele Tara , Wyte-Lake Tamar , Couig Mary Pat , Bell Sue Anne , Mammen Manoj J , Wells Valerie , Castner Jessica 
Published: February 2024

BackgroundThe efficacy of household emergency preparedness interventions for community-dwelling, non-institutionalized people is largely unknown.ObjectiveTo ascertain the state of the science on social support, educational, and behavioral modification interventions to improve all-hazard household disaster preparedness.DesignSystematic review and meta-analysis.MethodsDatabases, trial registers, reports, and websites were searched, and citation trails followed utilizing replicable methods. Individual, cluster, and cross-over randomized controlled trials of non-institutionalized, community-dwelling populations and non-randomized controlled trials, controlled before-after, and program evaluation studies were included. At least two review authors independently screened each potentially relevant study for inclusion, extracted data, and assessed the risk of bias. Risk of bias was assessed using Cochrane’s RoB2 tool for randomized studies and ROBINS-I tool for nonrandomized studies. Meta-analyses were applied using a random-effects model. Where meta-analysis was not indicated, results were synthesized using summary statistics of intervention effect estimates and vote counting based on effect direction. The evidence was rated using GRADE.Results17 studies were included with substantial methodological and clinical diversity. No intervention effect was observed for preparedness supplies (OR = 6.12, 95% 0.13 to 284.37) or knowledge (SMD = 0.96, 95% CI −0.15 to 2.08) outcomes. A small positive effect (SMD = 0.53, 95% CI 0.16 to 0.91) was observed for preparedness behaviors, with very low certainty of evidence. No studies reported adverse effects from the interventions.ConclusionResearch designs elucidating the efficacy of practical yet complex and multi- faceted social support, educational, and behavioral modification interventions present substantial methodological challenges where rigorous study design elements may not match the contextual public health priority needs and resources where interventions were delivered. While the overall strength of the evidence was evaluated as low to very low, we acknowledge the valuable and informative work of the included studies. The research represents the seminal work in this field and provides an important foundation for the state of the science of household emergency preparedness intervention effectiveness and efficacy. The findings are relevant to disaster preparedness practice and research, and we encourage researchers to continue this line of research, using these studies and this review to inform ongoing improvements in study designs.
Access to health and social protection policies by homeless people during the COVID-19 pandemic: a mixed-methods case study on tailored inter-sector care during a health emergency
Authors: Martins Ana Luisa Jorge , de Souza Anelise Andrade , da Silva Gabriela Drummond Marques , Dantas Ana Carolina de Moraes Teixeira Vilela , Marinho Rafaela Alves , Fernandes Luísa da Matta Machado , Oliveira Ana Maria Caldeira , Magalhães Júnior Helvécio Miranda , Paes-Sousa Rômulo 
Published: February 2024

IntroductionThe article analyzed homeless people's (HP) access to health and social protection policies and tailored inter-sector care, including emergency measures, during the COVID-19 pandemic in Belo Horizonte (BH), capital of Minas Gerais state, Brazil. It intended to provide data on HP and evaluate existing public policies focused on vulnerable populations during this health emergency.MethodsThe study adopted a mixed-methods design with triangulation of quantitative and qualitative data.ResultsSocial cartography showed that in the early months of the pandemic, the health administration had difficulty reordering the health system, which experienced constant updates in the protocols but was nevertheless consolidated over the months. The evidence collected in the study showed that important emergency interventions in the municipality of BH involved activities that facilitated access by HP to the supply of services.DiscussionThe existence of national guidelines for inter-sector care for HP cannot be ruled out as a positive influence, although the municipalities are responsible for their implementation. Significantly, a health emergency was necessary to intensify the relationship between health and social protection services. Roving services were among those with the greatest positive evidence, with the least need for infrastructure to be replicated at the local level. In addition, the temporary supply of various inter-sector services, simultaneously with the provision of day shelters by organized civil society, was considered a key factor for expanding and intensifying networks of care for HP during the emergency phase. A plan exists to continue and expand this model in the future. The study concluded that understanding the inter-sector variables that impact HP contributes to better targeting of investments in interventions that work at the root causes of these issues or that increase the effectiveness of health and social protection systems.
Single-cell profiling and functional screening reveal crucial roles for lncRNAs in the epidermal re-epithelialization of human acute wounds
Authors: Xiao Yunting , Zhang Chenyang , Liu Xiuping , Yang Yong , Landén Ning Xu , Zhang Zhao , Li Dongqing 
Published: February 2024

ObjectivesRe-epithelialization is an important physiological process for repairing skin barrier function during wound healing. It is primarily mediated by coordinated migration, proliferation, and differentiation of keratinocytes. Long noncoding RNAs (lncRNAs) are essential components of the noncoding genome and participate in various biological processes; however, their expression profiles and function in re-epithelialization during wound healing have not been established.MethodsWe investigated the distribution of lncRNAs during wound re-epithelialization by comparing the genomic profiles of uninjured skin and acute wound (AW) from healthy donors. We performed functional screening of differentially expressed lncRNAs to identify the important lncRNAs for re-epithelialization.ResultsThe expression of multiple lncRNAs is changed during human wound re-epithelialization process. We identified VIM-AS1, SMAD5-AS1, and LINC02581 as critical regulators involved in keratinocyte migration, proliferation, and differentiation, respectively.ConclusionLncRNAs play crucial regulatory roles in wound re-epithelialization. We established lncRNA expression profile in human acute wounds compared with intact skin, offering valuable insights into the physiological mechanisms underlying wound healing and potential therapeutic targets.
Beyond the First Year: Epidemiology and Management of Late-Onset Opportunistic Infections After Kidney Transplantation
Authors: Esnault V. , Hoisnard L. , Peiffer B. , Fihman V. , Fourati S. , Angebault C. , Champy C. , Gallien S. , Attias P. , Morel A. , Grimbert P. , Melica G. , Matignon M. 
Published: February 2024

Late opportunistic infections (OI) occurring beyond the first year after kidney transplantation (KT) are poorly described and not targeted by prophylactic strategies. We performed a ten-year retrospective monocentric cohort study describing epidemiology, risk factors and impact of late OI occurring 1 year after KT. We included clinically symptomatic OI requiring treatment besides BK virus nephropathy. Control groups included early OI occurring in the first year after KT, and KT recipients without OI since KT and alive with a functional allograft at 1 year. Among 1066 KT recipients, 185 (19.4%) presented a first episode of OI 21.0 (8.0–45.0) months after KT: 120 late OI (64.9%) and 65 early OI (35.1%). Late OI were mainly viral (N = 83, 69.2%), mostly herpes zoster (HZ) (N = 36, 43.4%). Pneumocystis represented most late fungal infections (N = 12/25, 48%). Compared to early OI, we reported more pneumocystis (p = 0.002) and less invasive aspergillosis (p = 0.01) among late OI. Patients with late OI were significatively younger at KT (54.0 ± 13.3 vs. 60.2 ± 14.3 years, p = 0.05). Patient and allograft survival rates between late OI and control groups were similar. Only age was independently associated with mortality. While late OI were not associated with higher mortality or graft loss, implementing prophylactic strategies might prevent such infections.
An Inulin-Type Fructan CP-A from Codonopsis pilosula Alleviated 5-Fluorouracil-Induced Intestinal Mucositis via the ERK/MLCK/MLC2 Pathway and Regulation of Gut Microbiota
Authors: Zhou Jiangtao , Li Deyun , Wang Jiajing , Cheng Zhuoyang , Wang Changjian , Zhang Xuepeng , Xu Xiexin , Gao Jianping 
Published: February 2024

Intestinal mucositis (IM) is a common adverse effect of chemotherapy, limiting its clinical application. Codonopsis pilosula-derived CP-A (an inulin-type fructan) is an edible Chinese medicine with anti-inflammatory and gastrointestinal protective effects, which may be useful for treating IM. Here, we explored CP-A’s role in ameliorating IM induced by 5-fluorouracil (5-FU) and investigated the underlying mechanism using in vitro experiments and rat models. Western blotting, immunohistochemistry (IHC), and real-time PCR (RT-PCR) analyses were used to assess protein expression related to the extracellular-regulated protein kinases (ERK)/myosin light chain kinase (MLCK)/myosin light chain 2 (MLC2) signaling pathway and tight junction proteins. Inflammatory factors were quantified using enzyme-linked immunosorbent assays (ELISAs), and 16S rRNA amplicon sequencing was employed for cecum content analysis. The results indicated that CP-A restored body weight and food intake and reversed histopathological changes in IM rats. Further, abnormal MLCK activation induced by 5-FU was attenuated by CP-A via the ERK/MLCK/MLC2 pathway. CP-A treatment improved tight junction protein levels and reduced inflammatory factor expression. Moreover, CP-A intervention regulated the intestinal microbiota community structure, increasing the abundance of Lactobacillus and decreasing the abundance of Shigella. In conclusion, CP-A mitigates 5-FU-induced IM by inhibiting the ERK/MLCK/MLC2 pathway, reducing the expression of inflammatory factors, improving the intestinal mucosal barrier, and regulating the intestinal microbial community. This study highlights CP-A’s therapeutic potential in IM treatment and provides insights for future research.
Response and Resilience of Scenedesmus rubescens Microalgae to ZnO Nanoparticles
Authors: Tzanakis Nikolaos , Aravantinou Andriana F. , Manariotis Ioannis D. 
Published: February 2024

Microalgae are microorganisms of great importance for aquatic ecosystems. The investigation of their interaction with potential environmental stressors like nanoparticles (NPs) is essential in order to assess their behavior and fate in aquatic ecosystems. The scope of this work is to investigate the response and potential toxic effects of the short-term exposure of Scenedesmus rubescens microalga to zinc oxide (ZnO) NPs with various initial nitrate concentrations in the culture medium. Scenedesmus rubescens was cultivated in four different compositions of modified BG-11 with a nitrate content varying from 0 to 300 mg/L, and it was exposed to four concentrations of ZnO NPs, ranging from 0.081 to 81 mg/L. S. rubescens was found to be resilient towards ZnO NP toxicity. The results also highlight the fact that the toxic effects of ZnO NPs on microalgae are highly dependent on the species tested. The nitrate content of the medium did not affect the toxicity of ZnO NPs but had a significant impact on cell concentration, as it was observed at an initial nitrate concentration of 300 mg/L. Further investigation should focus on studying the morphological and metabolic characteristics and mechanisms contributing to this species’ resilience.
The efficacy of bacteriophage/probiotic combination therapy in periodontal treatment
Authors: Galieva A. S. , Davidovich N. V. , Oрravin A. S. , Bashilova E. N. , Ryumin K. R. , Bazhukova T. A. 
Published: February 2024

Relevance. Periodontal inflammations result from chronic, persistent infections triggered by dysbiosis-induced shifts within the microbial community. The high prevalence, multifactorial nature and challenging management of periodontal disease create an environment ripe for ongoing advancements in treatment modalities.Study objective: To validate, using clinical and laboratory test data, the ef-ficacy of combined treatment involving bacteriophages and probiotics in manag-ing chronic periodontitis.Materials and methods. A total of 100 patients aged 18 to 45 with perio-dontal inflammation underwent clinical laboratory examinations before receiving combination treatment. The patients were divided into two groups: Group 1 re-ceived conventional treatment based on clinical recommendations, while Group 2 received sequential treatment with a bacteriophage cocktail (targeting 81 phages against A. actinomycetemcomitans, B. licheniformis, B. fragilis, E. cloacae, E. fae-calis, K. pneumonia, S. aureus, S. pyogenes, Wolinella spp. among others) fol-lowed by a probiotic containing S. Salivarius. Periodontal pocket lavages served as study material. Periodontal pathogens were isolated using real-time PCR, and proinflammatory cytokines were identified via enzyme immunoassay. Statistical analysis was conducted using STATA v.12 software.Results. Following bacteriophage/probiotic combination treatment, positive changes in study indices and a reduction in periodontopathogenic microbiota were observed. Significant decreases were noted in the levels of key periodontal pathogens: P. gingivalis (5.2-fold decrease, p < 0.001), P. intermedia (3.6-fold decrease, p < 0.001; T. forsythia (3.8-fold decrease, p = 0.905), T. denticola 4-fold decrease, p < 0.001. Levels of IL1-β decreased by factors of 4.29 (p < 0.001) and 8.59 (p = 0.02) in severity subgroups, while IL6 levels decreased by factors of 4.39 (p < 0.001) and 5.94 (p = 0.0002). The lowest TNF-α levels (2.13 in mild CGP subgroup and 2.11 in moderate CGP subgroup) were observed post-treatment (p < 0.001; p = 0.0005).Conclusion. The combination treatment involving the selected drugs exhibited notable therapeutic effectiveness in the management of chronic periodontitis. This approach not only avoided the necessity for systemic antibacterial agents but also facilitated prolonged remission by eradicating periodontopathogenic microbiota in patients with chronic periodontitis. The etiopathogenetic nature of this treatment represents a promising paradigm in the management of periodontal inflammation.
Malabaristas urbanos e a narrativa de uma cidade cultural:
Authors: Pereira Jesus 
Published: February 2024

O presente artigo tem como objetivo refletir como a cidade de Imperatriz-MA pode ser narrada por meio das práticas cotidianas dos malabaristas, nos semáforos. Seguindo o viés de autores como Agier (2011) e Certeau (2018) analisar como tais atores sociais “fazem” e “narram” a cidade demonstrando outras possibilidades que vai além das representações capitalcentricas (ESCOBAR,2005) de urbe, tão difundida pela classe empresarial local, com apoio ou omissão de grande parte classe intelectual local. Assim, por meio da observação de um conjunto de situações ligadas ao semáforo e ao itinerário de alguns membros da Trupe de Habilidades Circense (THC) foi possível caracterizar e perceber como as relações e técnicas de poder (MURA,2017) se capilarizam em vários sentidos denotando táticas, de um lado, e processos de invisbilização da alteridade, de outro. Tal campo foi alicerçado por meio de registros fotográficos, uma inserção cotidiana e diálogos desenvolvido ao longo de várias situações ocorridas de 2018 até os dias atuais.