bluuebunny/crossref_metadata_2025_split huggingface dataset:
The anti-HIV drug abacavir stimulates β-catenin activity in osteoblast lineage cells
Authors: Olali Arnold Z , Wallace Jennillee , Gonzalez Hemil , Carpenter Kelsey A , Patel Niyati , Winchester Lee C , Podany Anthony T , Venkatesh Ishwarya , Narasipura Srinivas D , Al-Harthi Lena , Ross Ryan D 
Published: March 2024

Abstract
Bone mineral density (BMD) loss in people living with HIV occurs with the initiation of combined antiretroviral therapy (cART), particularly with tenofovir disoproxil fumarate (TDF) containing cART. Switching from TDF to abacavir (ABC) or dolutegravir (DTG) leads to increased BMD. Whether BMD gains are due to cessation of TDF or anabolic effects of ABC or DTG is unclear. We investigated the effects of ABC and DTG on osteoblast lineage cells in vitro and in vivo. Primary human osteoblasts and male C57BL/6 mice were treated with individual antiretrovirals (ARVs) or a combination of ABC/DTG/lamivudine (3TC). Nearly all ARVs and cART inhibited osteogenic activity in vitro. Due to the importance of Wnt/β-catenin in bone formation, we further investigated ARV effects on the Wnt/β-catenin pathway. ABC, alone and as part of ABC/DTG/3TC, increased osteoblastic β-catenin activity as indicated by increased TOPFlash activity, hypo-phosphorylated (active) β-catenin staining, and β-catenin targeted gene expression. Mice treated with TDF had decreased lumbar spine BMD and trabecular connectivity density in the vertebrae, while those treated with ABC/DTG/3TC reduced cortical area and thickness in the femur. Mice treated with ABC alone had no bone structural changes, increased circulating levels of the bone formation marker, P1NP, and elevated expression of the Wnt/β-catenin target gene, Lef1, in osteocyte enriched samples. Further, bones from ARV-treated mice were isolated to evaluate ARV distribution. All ARVs were detected in the bone tissue, which was inclusive of bone marrow, but when bone marrow was removed, only TDF, ABC, and DTG were detected at ~0.1% of the circulating levels. Overall, our findings demonstrate that ABC activates Wnt/β-catenin signaling, but whether this leads to increased bone formation requires further study. Assessing the impact of ARVs on bone is critical to informing ARV selection and/or discovery of regimens that do not negatively impact the skeleton.
Merging architectural design and robotic planning using interactive agent-based modelling for collective robotic construction
Authors: Leder Samuel , Menges Achim 
Published: March 2024

Abstract
Most research on collective robotic construction (CRC) separates the architectural design and robotic path planning phases of the overall construction process. Specifically, a structure is designed and afterwards sent to a planner or compiler that returns instructions for the assembly of the structure with the robots at hand. Although this has led to the assembly of spatially complex structures, it obscures the planning process, making it inaccessible to the architect. Considering that one potential of CRC is that the architect can perform as more than a designer of static structures, this paper showcases how agent-based modelling can collapse the architectural design and robotic planning phases for CRC. As such the overall construction workflow is upended, leading to more designer control, adjustment for tolerances in the construction process, a more general understanding of the processes, and the potential for architectural reconfiguration when working with CRC systems. This is demonstrated through the presentation of an agent-based model for assembling a planar structure using a previously developed CRC system.
Ices on pebbles in protoplanetary discs
Authors: Topchieva A , Molyarova T , Akimkin V , Maksimova L , Vorobyov E 
Published: March 2024

ABSTRACT
The formation of solid macroscopic grains (pebbles) in protoplanetary discs is the first step towards planet formation. We aim to study the distribution of pebbles and the chemical composition of their ice mantles in a young protoplanetary disc. We use the two-dimensional hydrodynamical code feosad in the thin-disc approximation, which is designed to model the global evolution of a self-gravitating viscous protoplanetary disc taking into account dust coagulation and fragmentation, thermal balance, and phase transitions and transport of the main volatiles (H2O, CO2, CH4, and CO), which can reside in the gas, on small dust ($\lt 1\, \mu\mathrm{ m}$), on grown dust ($\gt 1\, \mu\mathrm{ m}$) and on pebbles. We model the dynamics of the protoplanetary disc from the cloud collapse to the 500 kyr moment. We determine the spatial distribution of pebbles and composition of their ice mantles and estimate the mass of volatiles on pebbles, grown dust, and small dust. We show that pebbles form as early as 50 kyr after the disc formation and exist until the end of simulation (500 kyr), providing prerequisites for planet formation. All pebbles formed in the model are covered by icy mantles. Using a model considering accretion and desorption of volatiles on to dust/pebbles, we find that the ice mantles on pebbles consist mainly of H2O and CO2, and are carbon-depleted compared to gas and ices on small and grown dust, which contain more CO and CH4. This suggests a possible dominance of oxygen in the composition of planets formed from pebbles under these conditions.
A comprehensive model for the formation and evolution of the faintest Milky Way dwarf satellites
Authors: Ahvazi Niusha , Benson Andrew , Sales Laura V , Nadler Ethan O , Weerasooriya Sachi , Du Xiaolong , Bovill Mia Sauda 
Published: March 2024

ABSTRACT
In this study, we modify the semi-analytic model galacticus in order to accurately reproduce the observed properties of dwarf galaxies in the Milky Way. We find that reproducing observational determinations of the halo occupation fraction and mass–metallicity relation for dwarf galaxies requires us to include H2 cooling, an updated ultraviolet background radiation model, and to introduce a model for the metal content of the intergalactic medium. By fine-tuning various model parameters and incorporating empirical constraints, we have tailored the model to match the statistical properties of Milky Way dwarf galaxies, such as their luminosity function and size–mass relation. We have validated our modified semi-analytic framework by undertaking a comparative analysis of the resulting galaxy–halo connection. We predict a total of $300 ^{+75} _{-99}$ satellites with an absolute V-band magnitude (MV) less than 0 within 300 kpc from our Milky Way analogues. The fraction of subhaloes that host a galaxy at least this bright drops to 50 per cent by a halo peak mass of ∼8.9 × 107 M⊙, consistent with the occupation fraction inferred from the latest observations of Milky Way satellite population.
A comprehensive study of orbital evolution of LMC X-4: existence of a second derivative of the orbital period
Authors: Jain Chetana , Sharma Rahul , Paul Biswajit 
Published: March 2024

ABSTRACT
We report here results from pulse arrival time delay analysis of the eclipsing high-mass X-ray binary (HMXB) pulsar LMC X-4 using observations made with the Rossi X-ray Timing Explorer, XMM–Newton, NuSTAR (Nuclear Spectroscopic Telescope ARray), and AstroSat. Combining the orbital parameters determined from these observations with the historical measurements dating back to 1998, we have extended the Tπ/2 epoch history of LMC X-4 by about 4600 binary orbits spanning about 18 yr. We also report mid-eclipse time measurements (Tecl) using data obtained from wide-field X-ray monitors of MAXI-GSC (Monitor of All-sky X-ray Image – Gas Slit Camera) and Swift-BAT (Burst Alert Telescope). Combining the new Tπ/2 and Tecl estimates with all the previously reported values, we have significantly improved the orbital evolution measurement, which indicates that the orbital period is evolving at a time-scale ($P_{\rm orb}/\dot{P}_{\rm orb}$) of about 0.8 Myr. For the first time in an accreting X-ray pulsar system, we confirm the existence of a second derivative of the orbital period, having an evolution time-scale ($\dot{P}_{\mathrm{ orb}}/\ddot{P}_{\mathrm{ orb}}$) of about 55 yr. Detection of a second derivative of the orbital period in LMC X-4 makes its orbital evolution time-scale more uncertain, which may also be true for other HMXBs. Independent solutions for the orbital evolution measurement using the mid-eclipse data and the pulse timing data are consistent with each other, and help us put an upper limit of 0.009 on the eccentricity of the binary system.
The white dwarf binary pathways survey – X. Gaia orbits for known UV excess binaries
Authors: Garbutt J A , Parsons S G , Toloza O , Gänsicke B T , Hernandez M S , Koester D , Lagos F , Raddi R , Rebassa-Mansergas A , Ren J J , Schreiber M R , Zorotovic M 
Published: March 2024

ABSTRACT
White dwarfs with an F, G, or K type companion represent the last common ancestor for a plethora of exotic systems throughout the galaxy, though to this point very few of them have been fully characterized in terms of orbital period and component masses, despite the fact several thousand have been identified. Gaia data release 3 has examined many hundreds of thousands of systems, and as such we can use this, in conjunction with our previous UV excess catalogues, to perform spectral energy distribution fitting in order to obtain a sample of 206 binaries likely to contain a white dwarf, complete with orbital periods, and either a direct measurement of the component masses for astrometric systems, or a lower limit on the component masses for spectroscopic systems. Of this sample of 206, four have previously been observed with Hubble Space Telescope spectroscopically in the ultraviolet, which has confirmed the presence of a white dwarf, and we find excellent agreement between the dynamical and spectroscopic masses of the white dwarfs in these systems. We find that white dwarf plus F, G, or K binaries can have a wide range of orbital periods, from less than a day to many hundreds of days. A large number of our systems are likely post-stable mass transfer systems based on their mass/period relationships, while others are difficult to explain either via stable mass transfer or standard common envelope evolution.
Formation of lower mass-gap black hole–neutron star binary mergers through super-Eddington stable mass transfer
Authors: Zhu Jin-Ping , Qin Ying , Wang Zhen-Han-Tao , Hu Rui-Chong , Zhang Bing , Wu Shichao 
Published: March 2024

ABSTRACT
Super-Eddington accretion of neutron stars (NSs) has been suggested both observationally and theoretically. In this paper, we propose that NSs in close-orbit binary systems with companions of helium (He) stars, most of which systems form after the common-envelope phase, could experience super-Eddington stable Case BB/BC mass transfer (MT), and can sometimes undergo accretion-induced collapse (AIC), resulting in the formation of lower mass-gap black holes (mgBHs). Our detailed binary evolution simulations reveal that AIC events tend to happen if the primary NSs have an initial mass ${\gtrsim} 1.7\, {\rm M}_\odot$ with a critical accretion rate of ≳300 times the Eddington limit. These mgBHs would have a mass nearly equal to or slightly higher than the NS maximum mass. The remnant mgBH–NS binaries after the core collapses of He stars are potential progenitors of gravitational-wave (GW) sources. Multimessenger observations between GW and kilonova signals from a population of high-mass binary NS and mgBH–NS mergers formed through super-Eddington stable MT are helpful in constraining the maximum mass and equation of state of NSs.
Probiotics supplementation during pregnancy or infancy on multiple food allergies and gut microbiota: a systematic review and meta-analysis
Authors: Jiang Lan , Zhang Lili , Xia Jiayue , Cheng Lei , Chen Guoxun , Wang Jin , Raghavan Vijaya 
Published: March 2024

Abstract

Context
Probiotics show promise in preventing and managing food allergies, but the impact of supplementation during pregnancy or infancy on children's allergies and gut microbiota remains unclear.

Objective
This study aimed to assess the effects of maternal or infant probiotic supplementation on food allergy risk and explore the role of gut microbiota.

Data Sources
A systematic search of databases (PubMed, Cochrane Library, Embase, and Medline) identified 37 relevant studies until May 20, 2023.

Data Extraction
Two independent reviewers extracted data, including probiotics intervention details, gut microbiota analysis, and food allergy information.

Data Analysis
Probiotics supplementation during pregnancy and infancy reduced the risk of total food allergy (relative risk [RR], 0.79; 95% CI, 0.63-0.99), cow-milk allergy (RR, 0.51; 95% CI, 0.29-0.88), and egg allergy (RR, 0.57; 95% CI, 0.39-0.84). Infancy-only supplementation lowered cow-milk allergy risk (RR, 0.69; 95% CI, 0.49-0.96), while pregnancy-only had no discernible effect. Benefits were observed with over 2 probiotic species, and a daily increase of 1.8 × 109 colony-forming units during pregnancy and infancy correlated with a 4% reduction in food allergy risk. Children with food allergies had distinct gut microbiota profiles, evolving with age.

Conclusions
Probiotics supplementation during pregnancy and infancy reduces food allergy risk and correlates with age-related changes in gut microbial composition in children.

Systematic Review Registration
PROSPERO registration no. CRD42023425988.
Foreign Travelers’ Accounts and Fanny Calderón de la Barca’s Life in Mexico
Authors: Parra Lazcano Lourdes 
Published: March 2024

Abstract
Foreign travelers arrived in large numbers in Mexico, especially after Mexican War of Independence, to see the country and access its commercial potential. Each of them talked about the Valley of Mexico, its richness and human diversity. The way these travelers wrote about their “gazes” over this valley—in particular Fanny Calderón de la Barca—is key to understanding the politics of their trips. After their initial viewing, foreign travelers described the Mexican social and political situation as ripe for exploitation and improvement. The chapter presents anecdotes and accounts of foreign travelers in Mexico during the nineteenth century. It primarily focuses on Fanny Calderón de la Barca and her work, Life in Mexico: Residence of Two Years in That Country. Calderón de la Barca’s work is relevant because she was the wife of the first Spanish minister of independent Mexico and had the opportunity to travel extensively throughout the country. Moreover, the work is considered to be a crucial text in terms of history, politics, and literature, despite her tendency to disseminate gender stereotypes and racist and classist assumptions. The work of Fanny Calderón de la Barca, and her gaze as it falls upon the Valley of Mexico, reflect the politics of mid-19th-century Mexico.
Taíno Religion
Authors: Stevens-Arroyo Anthony 
Published: March 2024

Abstract
This chapter introduces the Taíno religion, which is the first religion known in the Caribbean. It details the intricacy of the Taínos’ religious system, which integrated social behavior and nature. In contrast to scriptural religions, the Taínos trusted instead their own unspoiled and immediate response to the world around them. Religious wonder at the manifestation of spiritual forces in nature is a primordial human experience that exceeded the boundaries of earth religion and found its way into many scriptures. However, the focus on nature did not rob the Taíno belief system of the moral arc that all religions use to define right and wrong in social behavior.
Gender in Caribbean Religion
Authors: Otero Solimar 
Published: March 2024

Abstract
This chapter focuses on Afro-Caribbean expressions of gender, power, and place in traditions like Lukumí, Vodou, Palo, and Espiritismo. Gender is the focal point where race, colonialization, and sexuality come together to illuminate the intersectionality and fissures of creolized cultural life. The ways that gender is performed, produced, and circumscribed in Afro-Caribbean religious expression situate the nature of heated debates about authenticity, modernity, and nation-building in the Caribbean. This analysis of gender in Caribbean religion explores ritual, ethnography, and narrative. It will pay special attention to sites of reinvention and vernacular expressions coming from especially women and LGBTQ practitioners of Afro-Caribbean religions.
Rituals
Authors: Clark Mary Ann 
Published: March 2024

Abstract
This chapter focuses on rituals within the Yoruba religious complex variously known as Santería, Lukumí, and Regla de Ocha. It explains that rituals performed by participants in African-based religions in the Americas are the most important aspects of the religion. Rituals are intended to make the life or lives of the participants better, and more in line with each individual’s destiny for this lifetime. In the Caribbean and parts of Central and South America, groups of the enslaved and the formerly enslaved worked together to recreate the religious practices of their homelands. The chapter reveals that rituals allow individuals to be brought into the religious complex while also making connections with deities and other members of the community.
Wholeness by Every Means
Authors: Wood Funlayo E. 
Published: March 2024

Abstract
This chapter discusses the practice of religiomedical healing in the Caribbean. It highlights how healing is a centrifugal force in Caribbean religious practice. In the Caribbean, people of all kinds, regardless of affiliation or status, may employ spiritual healers or religiomedical healing modalities at some point in their lives, especially for African and Indian descendants whose healthcare was largely ignored, as they were considered expendable and replaceable labor. The chapter then provides an overview of case studies of the most prominent religiomedical healing traditions and modalities from around the region. It also explains how Caribbean religious traditions will continue to make important contributions to the health and well-being of Caribbean peoples.
Possession
Authors: Johnson Paul Christopher 
Published: March 2024

Abstract
This chapter explores the issues surrounding spirit possession within Caribbean religions. It cites how the notion of possession questioned the idea of the autonomous, rational, free agent. While slavery was the Caribbean’s foundational institution and system of exchange, spirit possession provided a key category that helped affix the great ontological and social divide that separated those capable of ownership from those who could by right be owned. The question of the colonial occupation of territory or enslaved persons raised the issues of the economic value of land and spirits’ presence in the bodies of the enslaved. The chapter explains how the history of slavery hovers and chains the tropes of spirit possession, material possessions, and possessable persons.
Protestant Christianity
Authors: Cardoza-Orlandi Carlos F. 
Published: March 2024

Abstract
This chapter explores the history of Colonial Protestant Christianity in the Caribbean. It elaborates on the diversity of Protestant expression across Europe. The region became a geopolitical and religious location of violent encounters, imperial tensions and alliances, and human accounts of exploitation and survival due to the religious and political turmoil and the power struggle between Roman Catholicism and Protestant traditions in Europe. Thus, the narrative of Protestantism in the Caribbean primarily revolves around several key contexts of colonial structure, plantation economy, conquest, exploitation of indigenous and mixed-race people, and slavery. The chapter also considers the tensions concerning traditions, uncertainties and unexpected alliances, rebellions, and Caribbean missionary work.
The Lukumí in Cyberspace
Authors: Gonzalez Jeffery M. 
Published: March 2024

Abstract
The advent of cyberspace contributed significantly to the development and impact of globalization on religious traditions. For the Lukumí, the Internet with its numerous social media applications provides new methods of communication between geographically dispersed Lukumí communities. The diffusion of the Lukumí worldview, driven by the migration of practitioners, has acquired new characteristics during the past decades with the expansion of the Internet. A survey conducted with Facebook users attempted to explore some of the dynamics involved in the relationship between new communication technologies and the Lukumí tradition. Throughout the chapter the concepts of Orisha diaspora, Orisha capital, and Orisha marketplace are discussed as guideposts in the expanding conversation of technology and religious practices. The changing nature of the Lukumí tradition in Cuba and around the globe is explored as a growing global Lukumí community that continues to question the fundamental concepts of authenticity and sacredness as encounters with other Orisha traditions. Moreover, the expansion of social media has created hybridized traditions, commercialization of sacred icons, and the presence of unscrupulous priests using the Internet to prey on unknowing novices. In summary, this chapter provides a framework to understand how technology has created a new frontier in the expansion, maintenance, and development of the Lukumí tradition.
Santería
Authors: Rauhut Claudia 
Published: March 2024

Abstract
This chapter elaborates on the Afro-Cuban religion Santería, which is one of the most popular religions of African origin in the Americas. It explores a Cuban example of such a “renewal” or appropriation of the African past and present in Cuban Santería. African-based religions in the Americas are more of a product of a transatlantic religious agency that actively reformed and renewed those traditions until the present day. The chapter then discusses the processes of religious globalization and transnationalization after the 1990s before considering strategies of re-Africanization in translocal religious settings. It considers a version of Lúkúmí that offers a more differentiated perspective on the construction and appropriation of the Yoruba religion.
Mapping and writing as a co-creative therapeutic process
Authors: Potter Steve 
Published: March 2024

Abstract
Cognitive analytic therapy’s (CAT’s) conceptual tools and methods offer a scaffolding for a co-creative therapeutic partnership. CAT emphasizes doing therapy with rather than for, or to, the client. It combines personal problem solving with attention to a sense of self and in the process a more general relational and conversational awareness is developed. Whilst CAT centres on the written and diagrammatic reformulation with the client, it is important to not neglect the additional and continuous task of establishing and maintaining a healing narrative. The shared, in-session process of mapping the conversations, stories, and relationships as they develop depends on an open story approach and the sensitive exploration of words and the patterns they relate to. The approach to CAT described is one of several ways of using the CAT framework and it is a tribute to Ryle’s openness and pragmatism that the approach has not become model bound.