bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical evaluation of imidapril in congestive heart failure in dogs: results of the EFFIC study
Authors: Besche B. , Chetboul V. , Lachaud Lefay M.‐P. , Grandemange E. 
Published: February 2007

Objectives:The clinical efficacy and safety of imidapril were evaluated in dogs that presented with mild to severe congestive heart failure (New York Heart Association stage II to IV) by comparing the success rate of imidapril with a positive control by a non‐inferiority approach.Methods:This good, clinical practice compliant, multicentre study (EFFIC study) enrolled 142 client‐owned dogs and was conducted in 20 locations in France, Belgium and Germany. Dogs of various breed, age and weight were included in the study. These dogs were randomised into two groups that were treated for 84 days with either the test product, imidapril, or the positive control, benazepril, and followed up in parallel over this period. Both treatments were administered at a dose of 0·25 mg/kg once a day with the possibility of doubling this dose to 0·5 mg/kg if considered necessary from a clinical point of view. In addition, concomitant treatment was given to dogs presenting with pulmonary oedema and/or ascites, supraventricular tachyarrhythmia and/or dilated cardiomyopathy. The evolution of the New York Heart Association stage and the “functional signs” score were evaluated as primary efficacy criteria.Results:The success rate in the imidapril group was 66 compared with 68 per cent in the benazepril group. Regarding safety, 35 dogs in each group experienced at least one adverse event. Nine dogs in each group experienced at least one serious adverse event. The difference between these results was not statistically significant.ClinicalSignificance:Imidapril is as efficacious and safe as the reference product, benazepril.
VERIFYING VERY LARGE INDUSTRIAL CIRCUITS USING 100 PROCESSES AND BEYOND
Authors: FIX LIMOR , GRUMBERG ORNA , HEYMAN AMNON , HEYMAN TAMIR , SCHUSTER ASSAF 
Published: February 2007

Recent advances in scheduling and networking have paved the way for efficient exploitation of large-scale distributed computing platforms such as computational grids and huge clusters. Such infrastructures hold great promise for the highly resource-demanding task of verifying and checking large models, given that model checkers would be designed with a high degree of scalability and flexibility in mind. In this paper we focus on the mechanisms required to execute a high-performance, distributed, symbolic model checker on top of a large-scale distributed environment. We develop a hybrid algorithm for slicing the state space and dynamically distribute the work among the worker processes. We show that the new approach is faster, more effective, and thus much more scalable than previous slicing algorithms. We then present a checkpoint-restart module that has very low overhead. This module can be used to combat failures, the likelihood of which increases with the size of the computing plat-form. However, checkpoint-restart is even more handy for the scheduling system: it can be used to avoid reserving large numbers of workers, thus making the distributed computation work-efficient. Finally, we discuss for the first time the effect of reorder on the distributed model checker and show how the distributed system performs more efficient reordering than the sequential one. We implemented our contributions on a network of 200 processors, using a distributed scalable scheme that employs a high-performance industrial model checker from Intel. Our results show that the system was able to verify real-life models much larger than was previously possible.
Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells
Authors: Ogino Hideki , Nozaki Tadashige , Gunji Akemi , Maeda Miho , Suzuki Hiroshi , Ohta Tsutomu , Murakami Yasufumi , Nakagama Hitoshi , Sugimura Takashi , Masutani Mitsuko 
Published: February 2007

Abstract

Background
Many lines of evidence suggest that poly(ADP-ribose) polymerase-1 (Parp-1) is involved in transcriptional regulation of various genes as a coactivator or a corepressor by modulating chromatin structure. However, the impact of Parp-1-deficiency on the regulation of genome-wide gene expression has not been fully studied yet.

Results
We employed a microarray analysis covering 12,488 genes and ESTs using mouse Parp-1-deficient (Parp-1
-/-) embryonic stem (ES) cell lines and the livers of Parp-1
-/- mice and their wild-type (Parp-1
+/+) counterparts. Here, we demonstrate that of the 9,907 genes analyzed, in Parp-1
-/- ES cells, 9.6% showed altered gene expression. Of these, 6.3% and 3.3% of the genes were down- or up-regulated by 2-fold or greater, respectively, compared with Parp-1
+/+ ES cells (p < 0.05). In the livers of Parp-1
-/- mice, of the 12,353 genes that were analyzed, 2.0% or 1.3% were down- and up-regulated, respectively (p < 0.05). Notably, the number of down-regulated genes was higher in both ES cells and livers, than that of the up-regulated genes. The genes that showed altered expression in ES cells or in the livers are ascribed to various cellular processes, including metabolism, signal transduction, cell cycle control and transcription. We also observed expression of the genes involved in the pathway of extraembryonic tissue development is augmented in Parp-1
-/- ES cells, including H19. After withdrawal of leukemia inhibitory factor, expression of H19 as well as other trophoblast marker genes were further up-regulated in Parp-1
-/- ES cells compared to Parp-1
+/+ ES cells.

Conclusion
These results suggest that Parp-1 is required to maintain transcriptional regulation of a wide variety of genes on a genome-wide scale. The gene expression profiles in Parp-1-deficient cells may be useful to delineate the functional role of Parp-1 in epigenetic regulation of the genomes involved in various biological phenomena.
Therapy for pneumonitis and sialadenitis by accumulation of CCR2-expressing CD4+CD25+regulatory T cells in MRL/lpr mice
Authors: Hasegawa Hitoshi , Inoue Atsushi , Muraoka Masatake , Yamanouchi Jun , Miyazaki Tatsuhiko , Yasukawa Masaki 
Published: February 2007

Abstract
Adoptive transfer of CD4+CD25+ regulatory T cells has been shown to have therapeutic effects in animal models of autoimmune diseases. Chemokines play an important role in the development of autoimmune diseases in animal models and humans. The present study was performed to investigate whether the progression of organ-specific autoimmune diseases could be reduced more markedly by accumulating chemokine receptor-expressing CD4+CD25+ regulatory T cells efficiently in target organs in MRL/MpJ-lpr/lpr (MRL/lpr) mice. CD4+CD25+Foxp3+ T cells (Treg cells) and CD4+CD25+Foxp3+ CCR2-transfected T cells (CCR2-Treg cells) were transferred via retro-orbital injection into 12-week-old MRL/lpr mice at the early stage of pneumonitis and sialadenitis, and the pathological changes were evaluated. Expression of monocyte chemoattractant protein-1 (MCP-1)/CCL2 was observed in the lung and submandibular gland of the mice and increased age-dependently. The level of CCR2 expression and MCP-1 chemotactic activity of CCR2-Treg cells were much higher than those of Treg cells. MRL/lpr mice to which CCR2-Treg cells had been transferred showed significantly reduced progression of pneumonitis and sialadenitis in comparison with MRL/lpr mice that had received Treg cells. This was due to more pronounced migration of CCR2-Treg cells and their localization for a longer time in MCP-1-expressing lung and submandibular gland, resulting in stronger suppressive activity. We prepared chemokine receptor-expressing Treg cells and demonstrated their ability to ameliorate disease progression by accumulating in target organs. This method may provide a new therapeutic approach for organ-specific autoimmune diseases in which the target antigens remain undefined.
Incorporation of Fe in the interlayer of Na-bentonite via treatment with FeCl3 in acetone
Authors: Komlósi Andrea , Kuzmann Ernő , Nagy Noémi M. , Homonnay Zoltán , Kubuki Shiro , Kónya József 
Published: February 2007

AbstractThe effect of FeCl3 in acetonic medium on the structure of Na-bentonite was studied using X-ray diffraction (XRD), 57Fe Mössbauer spectroscopy, X-ray fluorescence spectroscopy and infrared spectroscopy to describe the structure of the bentonite before and after treatment. In the samples treated with FeCl3, an increase in the basal spacing was found by XRD, while a new magnetically split component assigned to Fe3+ incorporated within the interlayer regions of montmorillonite showed up in the low-temperature Mössbauer spectra. The Mössbauer parameters observed were close to those of Fe oxyhydroxides, suggesting the presence of some kind of nanoparticles. These results show that the treatment with acetonic FeCl3 solution is an effective method for introducing Fe into montmorillonite in the form of Fe3+ accommodated in the interlayer region. The treated samples proved to be efficient Lewis catalysts in the acylation of aldehydes (benzaldehyde and 4-OH-benzaldehyde) by acetic acid anhydride.
New African American life tables from 1935–1940 to 1985–1990
Authors: Elo Irma T. 
Published: February 2007

Abstract
New life tables for African Americans are presented from 1935 through 1990. They are based on a historical series of vital statistics data on deaths that have been corrected for age misreporting, on reconstructed population counts that have been adjusted for census underenumeration, and on births that have been corrected for underregistration. The new life tables show rapid mortality declines for both African American males and females from 1935 to 1950, and relatively steady reductions thereafter for females. The smaller declines in male mortality in young adulthood and middle age since the 1950s have led to exceptionally high ratios of male to female mortality at these ages. Corrections for census undercounts lead to higher values of life expectancy than in official life tables, but to less improvement over time. Official estimates of life expectancy at age 65 appear to be about 10% too high around 1940 but only about 1.5% too high in the late 1980s.
Changes in children’s time with parents: United States, 1981–1997
Authors: Sandberg John F. , Hofferth Sandra L. 
Published: February 2007

Abstract
In this paper we examine changes in the time American children spent with their parents between 1981 and 1997, and the contribution to these changes made by shifting patterns of female labor force participation, family structure, and parental education. We decompose changes into the parts attributable to changes in demographic characteristics and the parts probably due to changes in behavior. In general, children’s time with parents did not decrease over the period; in two-parent families it increased substantially. Population-level changes in demographic characteristics exerted only small direct effects on the time children spent with parents.
Evaluating the performance of the lee-carter method for forecasting mortality
Authors: Lee Ronald , Miller Timothy 
Published: February 2007

Abstract
Lee and Carter (LC) published a new statistical method for forecasting mortality in 1992. This paper examines its actual and hypothetical forecast errors, and compares them with Social Security forecast errors. Hypothetical historical projections suggest that LC tended to underproject gains, but by less than did Social Security. True e0 was within the ex ante 95% probability interval 97% of the time overall, but intervals were too broad up to 40 years and too narrow after 50 years. Projections to 1998 made after 1945 always contain errors of less than two years. Hypothetical projections for France, Sweden, Japan, and Canada would have done well. Changing age patterns of mortality decline over the century pose problems for the method.
War, peace, and fertility in Angola
Authors: Agadjanian Victor , Prata Ndola 
Published: February 2007

AbstractUsing data from a nationally representative survey conducted in 1996, some two years after the end of a major outbreak of war, we examine the impact of war on the timing of recent births and war-related differences in reproductive preferences in Angola. We find evidence of a wartime drop and a postwar rebound in fertility, but these trends vary greatly, depending on the type and degree of exposure to war and on women’s socioeconomic characteristics. At the same time, variations by parity are nonsignificant. In fertility preferences, the relative antinatalism of Angola’s most modernized urban area stands out, but outside this area, differences between areas that were more and less affected by war are also noticeable. We offer interpretations of our findings and outline their implications for Angola’s demographic future and demographic trends in similar settings.
An investigation of racial and ethnic disparities in birth weight in Chicago neighborhoods
Authors: Sastry Narayan , Hussey Jon M. 
Published: February 2007

Abstract
We examine differences in the mean birth weights of infants born to non-Hispanic black, non-Hispanic white, and Mexican-origin Hispanic mothers (of any race) in Chicago in 1990 using linear regression models with neighborhood fixed effects. Our pooled models accounted for 64% of the black-white difference and 57% of the black/Mexican-origin Hispanic difference. Differences in the relationship between measured characteristics and birth weight accounted for around half the birth-weight gap between non-Hispanic black and other infants. Efforts to close this gap must go beyond programs that aim to reduce the level of risk factors among black women to address the causes of differences in the effects of risk factors.
Metaphors of identity in dating ads and newspaper articles
Authors: Marley Carol 
Published: February 2007

AbstractThis article investigates metaphors of identity in dating ads and in two types of newspaper writing, ‘hard’ and ‘soft’ news articles. It focuses on issues of textualization and processing, and particularly on the role of cotext in decoding metaphors. Taking a pragmatic approach founded in the cooperative principle, it argues that the maxims of quality and relation play related but separable roles in the interpretation of identity metaphors; and that this process is guided and constrained by cotextual selections in the environment of the metaphorical term. The particular kinds of cotextual guidance provided by the writer are seen to vary according to genre-driven issues. These include the purpose and stylistic conventions of the genre in which the metaphor occurs and the circumstances under which the text is composed and read. Differing functional motivations are suggested for the use of identity metaphors in each of the genres considered.
Effectiveness of long-term cabergoline treatment for giant prolactinoma: study of 12 men
Authors: Shimon Ilan , Benbassat Carlos , Hadani Moshe 
Published: February 2007

Objective: To review our experience with cabergoline, a D2-selective dopamine agonist, for the treatment of giant prolactinomas.
Design: A retrospective case series; descriptive statistics.
Methods: The study group included 12 men aged 24–52 years (mean 39.2 years) treated for giant prolactinoma at our centers from 1997 to 2006. Cabergoline was started at a dose of 0.5 mg/three times a week and progressively increased as necessary to up to 7 mg/week. Patients were followed by hormone measurements, sellar magnetic resonance imaging, and visual examinations.
Results: In ten patients, cabergoline served as first-line therapy. The other two patients had previously undergone transsphenoidal partial tumor resection because of visual deterioration. Mean serum prolactin level before treatment was 14 393 ± 14 579 ng/ml (range 2047–55 033 ng/ml; normal 5–17 ng/ml). Following treatment, levels normalized in ten men within 1–84 months (mean, 25.3 months) and decreased in the other two to 2–3 times of normal. Tumor diameter, which measured 40–70 mm at diagnosis, showed a mean maximal decrease of 47 ± 21%; response was first noted about 6 months after the onset of treatment. Nine patients had visual field defects at diagnosis; vision returned to normal in three of them and improved in five. Testosterone levels, initially low in all patients, normalized in eight. There were no side effects of treatment.
Conclusion: Cabergoline therapy appears to be effective and safe in men with giant prolactinomas. These findings suggest that cabergoline should be the first-line therapy for aggressive prolactinomas, even in patients with visual field defects.
Könyvismertetések
Authors: Balogh Tibor , Duró Lajos , Hahn Noémi , Pléh Csaba , Garab Edit Anna 
Published: February 2007

Gervain Judit - Kovács Kristóf - Lukács Ágnes - Racsmány Mihály (szerk.): Az ezerarcú elme. Tanulmányok Pléh Csaba 60.
születésnapjára
(Balogh Tibor)
Nagy László
(Miklós): Az ismeretek
alkalmazásának pszichológiai problémái
(Duró Lajos)
Kiss Szabolcs:
Elmeolvasás
(Hahn Noémi)
Simon Baron-Cohen: Elemi különbség. Férfiak, nők és
a szélsőséges férfiagy
(Hahn Noémi)
Jean-Pierre Changeux: Raison et plaisir
(Pléh Csaba)
Eric R.
Kandel: In search of memory. The
emergence of a new science of mind
(Pléh
Csaba)
Daniel Schacter:
Az emlékezet hét bűne
(Garab Edit Anna)
Quantitative Trait Loci Controlling Fusarium Head Blight Resistance and Low Deoxynivalenol Content in Hexaploid Wheat Population from ‘Arina’ and NK93604
Authors: Semagn Kassa , Skinnes Helge , Bjørnstad Åsmund , Marøy Anne Guri , Tarkegne Yalew 
Published: February 2007

ABSTRACTBreeding for Fusarium head blight (FHB) resistant wheat adapted to the Norwegian climatic conditions is one of the top priorities in the country. This study was conducted to characterize QTLs for FHB resistance and low deoxynivalenol (DON) content in a population of 93 double haploid lines from a cross between ‘Arina’ and NK93604. Both parents have moderate levels of resistance to FHB. The population was assessed for FHB resistance under field conditions for 3 yr (2001 to 2003), and DON content was analyzed from seed samples in the 2002 experiment. The two traits showed significant genetic variation and were significantly correlated with each other. Composite interval mapping (CIM) identified four QTLs using the 3 yr mean for FHB resistance on chromosomes 1AL, 1BL, 6BS, and 7AL. The QTLs on 1AL, 1BL, and 7AL were consistently detected in all 3 yr, and explained 27.9, 19.6, and 14.8% of the phenotypic variation, respectively. The QTLs on chromosomes 1BL and 6BS originated from Arina, whereas those on 1AL and 7AL were from NK93604. None of the QTLs for FHB resistance detected in this study were coincident with those previously reported in the Arina/‘Forno’ population. Two major QTLs, both derived from NK93604, on chromosomes 1AL and 2AS were identified for DON content that explained 27.9 and 26.7% of the variation, respectively. A major QTL for FHB resistance on 1AL coincided with a QTL for DON content. As far as we are aware, the QTL on chromosome 1AL is novel and not reported elsewhere. Data from the present study provides breeders with additional information on chromosomal regions associated with FHB resistance and DON content in European wheats and will help guide the development of FHB‐resistant wheat.
Molecular Analysis of Soybean Lines with Low Palmitic Acid Content in the Seed Oil
Authors: Cardinal Andrea J. , Burton Joseph W. , Camacho-Roger Ana Maria , Yang Ji H. , Wilson Richard F. , Dewey Ralph E. 
Published: February 2007

ABSTRACTPalmitic acid is the major saturated fatty acid found in soybean [Glycine max (L.) Merr.] oil, accounting for approximately 11% of the seed oil content. Reducing the palmitic acid levels of the oil is desirable because of the negative health effects specifically associated with this fatty acid. One of the genetic loci known to reduce the seed palmitate content in soybean is fapnc. Previous studies indicated that fapnc is associated with a deletion in a gene (designated FATB) encoding 16:0‐ACP thioesterase activity. In this report, we isolated full length cDNAs of three of the four unique FATB genes expressed in soybean and show that the isoform designated GmFATB1a represents the specific gene deleted in lines possessing the fapnc locus. Allele specific primers corresponding to GmFATB1a were used to genotype plants from two F4‐derived populations that were segregating for fapnc The GmFATB1a‐specific markers were effective in accounting for 62 to 70% of the genotypic variation in palmitate content in the two populations studied. Because the markers developed in this study are 100% linked to the locus of interest, they should be particularly useful in marker‐assisted selection programs designed to lower the palmitic acid levels of soybean oil.
Cumulative Excess Body Mass Index and MGUS Progression to Myeloma
Authors: Liu Lawrence , Grandhi Nikhil , Wang Mei , Proskuriakova Ekaterina , Thomas Theodore , Schoen Martin W. , Sanfilippo Kristen M. , Carson Kenneth R. , Visram Alissa , Vachon Celine , Colditz Graham , Janakiram Murali , Ji Mengmeng , Chang Su-Hsin 
Published: February 2025

ImportanceObesity is a risk factor associated with multiple myeloma (MM) and its precursor, monoclonal gammopathy of unknown significance (MGUS). However, it is unclear how cumulative exposure to obesity affects the risk of MGUS progression to MM.ObjectiveTo determine the association of cumulative exposure to excess body mass index (EBMI), defined as BMI (calculated as weight in kilograms divided by height in meters squared) greater than 25, with risk of MGUS progression to MM.Design, Setting, and ParticipantsThis cohort study included patients with MGUS, including immunoglobin G, immunoglobin A, or light chain MGUS, from the nationwide US Veterans Health Administration database from October 1, 1999, to December 31, 2021. A published natural language processing–assisted model was used to confirm diagnoses of MGUS and progression to MM. Data were analyzed from February 12 to November 4, 2024.ExposuresCumulative EBMI was calculated by area under the curve of measured BMI subtracting the reference BMI at 25 during the first 3 years after MGUS diagnosis.Main Outcomes and MeasuresThe main outcome was progression from MGUS to MM. Multivariable Fine-Gray time-to-competing-event analyses, with death as the competing event, were used to determine associations.ResultsThe cohort included 22 429 patients with MGUS (median [IQR] age, 70.5 [63.5-77.9] years; 21 613 [96.4%] male), with 8329 Black patients (37.1%) and 14 100 White patients (62.9%). There were 4862 patients (21.7%) with reference range BMI (18.5 to &amp;lt;25), 7619 patients (34.0%) with BMI 25 to less than 30, and 8513 patients (38.0%) with BMI 30 or greater at the time of MGUS diagnosis. Compared with reference range BMI at MGUS diagnosis, patients with BMI 25 to less than 30 (adjusted hazard ratio [aHR], 1.17; 95% CI, 1.03-1.34) or 30 or greater (aHR, 1.27; 95% CI, 1.09-1.47) at MGUS diagnosis had higher risk of progression to MM. In patients with reference range BMI at MGUS diagnosis, each 1-unit increase of EBMI per year was associated with a 21% increase in progression risk (aHR, 1.21; 95% CI, 1.04-1.40). However, for patients with BMI 25 or greater at MGUS diagnosis, the incremental risk associated with cumulative EBMI exposure was not statistically significant.Conclusions and RelevanceThis cohort study found that, for patients with BMI 18.5 to less than 25 at the time of MGUS diagnosis, cumulative exposure to BMI 25 or greater was associated with an increased risk of progression. These findings suggest that for these patients, maintaining a healthy and stable weight following MGUS diagnosis may prevent progression to MM.