bluuebunny/crossref_metadata_2025_split huggingface dataset:
Liposomes as Transformative Tools in Drug Delivery, Therapeutics, and
Beyond
Authors: Srivastava Ashish , Singh Anshuman , Srivastava Parul , Wal Ankita , Wal Pranay , Yadav Anil Kumar , K Rai Awani 
Published: March 2024

Abstract:
Abstract: Liposomes are spherical vesicles composed of lipid bilayers that have gained significant
attention in the realm of drug delivery and therapeutic applications. They offer several advantages
over traditional drug delivery systems, including:

-Protection of drugs from degradation and clearance
-Enhanced bioavailability
- Reduced systemic toxicity
- Precise, site-specific drug delivery

To elucidate the multifaceted aspects of liposomes, from their fundamental structure and composition
to their cutting-edge applications in medicine and biotechnology.
This comprehensive review was conducted through a systematic search of relevant literature on liposomes.
The search was limited to English-language articles published in the past 10 years. A total
of 150 articles were selected for review based on their relevance and impact.

The review provides a detailed overview of the following aspects of liposomes:

-Structure and composition
- Mechanism of action
- Targeting strategies
- Preparation methods
- Biomedical and biotechnological applications

Liposomes are a promising drug delivery platform with the potential to revolutionize the treatment
of various diseases. Their unique properties, including biocompatibility, versatility, and tunability,
render them ideal for encapsulating a wide range of therapeutic agents. The review highlights the
significant progress made in liposome research in recent years, paving the way for their translation
into clinical practice.
Association Between Changes in Haematological Parameters and Mortality in Patients Hospitalized Due to Severe COVID-19 in a Peruvian Reference Hospital
Authors: Benavides-Luyo Claudia , Velasquez-Manrique Annie , Quinones-Laveriano Dante M , Chaupi-Rojas Susan , Azanero-Haro Johan , Soto Alonso 
Published: March 2024

Objective:
To determine the association between changes in haematological parameters
and mortality in patients hospitalized due to severe COVID-19 at a Peruvian reference hospital from
April to December 2020.

Materials and Methods:
Observational, analytical, historical cohort study based on the review of
clinical records of patients hospitalized due to severe COVID-19 from April to December 2020. We
evaluated changes in common haematological parameters, including white blood cells (WBCs), lymphocytes,
neutrophils, and platelet counts, as well as the neutrophil-to-lymphocyte ratio (NLR) on the
third and seventh days of hospitalization compared with admission values in the deceased and nondeceased
groups. Changes in haematological parameters were expressed as median and interquartile
ranges (IQR). Multivariate Poisson regression analysis was further done to evaluate the effect of
haematological changes in mortality, adjusting for gender, age, and comorbidities.

Results:
We included 1033 cases, of which 68.05% were male. Deceased patients had a significant
increase in total WBC on the third day (1.0 *103/μL; IQR -1.7 to 5.4) and the seventh day
(1.6*103/μL; IQR -1.9 to 4.9) compared to their admission values. The neutrophil count in the deceased
patients also increased on the third day (1.2; IQR -1.7 to 4.9) and seventh day (1.9; IQR-1.5 to
5.8), as did the NLR ratio on the third day (0.2; IQR -0.4 to 1.6) and seventh day (0.7; IQR -0.2 to
2.2). Surviving patients showed an opposite trend in these parameters. In contrast, platelet counts
increased on the third day (49*105/μL; IQR -0.3 to 1.3) and the seventh day (90*105; IQR 0.0 to 2.0)
in surviving patients, whereas deceased patients did not show significant changes. All these differences
remained statistically significant in the adjusted analysis.

Conclusion:
An increase in total WBC, neutrophils, and NLR at the third and seventh days compared
to admission values was associated with higher mortality in patients hospitalized due to COVID-19,
while an increase in platelet count was associated with decreased mortality. Monitoring these changes
can help in identifying those patients with higher mortality risk.
History of Edirne and the City’s Form
Authors: Erdoğan Nevnihal 
Published: March 2024

Situated in Thrace (Trakya) on the European side of the Marmara Region of
Turkey, the city of Edirne is today important as a border city that ranks as a cultural
and university center. Because it served as one of the Ottoman Empire’s three historical
capital cities (the others being Bursa and Istanbul), the city is an open-air museum with
very important monuments and architectural elements. Among the historical buildings
still extant are mosques, charity complexes, bridges, old shop buildings, caravansaries,
palaces, historical houses, and their quarters.

Developing out of its former role as an old Byzantine fortress, the city advanced greatly
as a Turkish-Muslim city during the Ottoman Empire. Its development was
significantly boosted by construction and improvements ordered by the successive
sultans, in their first-degree positions, and by high-ranking state officials of second and
third-degree positions. The significance of the role they played in the development of
the city is evident from the fact that they gave their names to many neighborhoods.
The concept of centralization became the catalyst for a significant change in the old
Paleo-Christian fortress city of Edirne. Ottoman monuments and shopping areas began
to cluster in the northeastern corner of the city. Within a period of 200 years after the
Turkish conquest, Edirne had acquired the look of a developed city with new districts
and inhabited quarters.Edirne’s form is the result of three distinct types of urban development specific to the
three periods of urban history: Roman/Byzantine, Ottoman, and Modern. The
Roman/Byzantine form was included in the Ottoman city, which took on a more
homogeneous form in the modern era.
A Mini Review on Analysis of Potential Antibacterial Activity of Symbiotic Bacteria from Indonesian Freshwater Sponge: An Unexplored and A Hidden Potency
Authors: Setiawan Edwin , Hermanto Michael Einstein , Abdulgani Nurlita , Prasetyo Endry Nugroho , Riani Catur , Wulandari Dyah , Budiharjo Anto 
Published: March 2024

Marine sponges have been investigated as potential bioresources because of their symbiotic relationship with microbes such as Actinobacteria that produce antibacterial substances. In contrast, a group of sponges, that inhabits freshwater environments called freshwater sponges (Order Spongillida Manconi & Pronzato, 2002) and consists of only one percent among all of the sponges’ species (Phylum Porifera Grant, 1836), has not yet intensively examined. For this reason, we screened, determined, evaluated, and reviewed by examining several databases in Scopus, Pub Med, and Google Scholar related to potential aspects of symbiotic bacteria and their antibacterial substances that can be further utilised and developed into synthesised antibacterial compounds, based on published metagenomic data of symbiotic bacteria in freshwater sponges. At the same time, we compared a composition of those freshwater symbionts to marine sponges’ symbionts whether those possess a similar composition or not. Moreover, a current report and a revisit study of freshwater sponges in East Java, initiate further direction on mapping of those symbiotic bacteria from Indonesia that can be nominated as potential groups possessing antibacterial properties.
PENGENDALIAN PERSEDIAAN PART NON MOVING DENGAN MENGGUNAKAN METODE FSN ANALISIS
Authors: Harthawan I Gusti Ngurah Putra , Manuaba Ida Bagus Putra , Pratama Tohir Rendra 
Published: March 2024

Agung Toyota Tabanan merupakan perusahaan yang bergerak di bidang otomotif serta mempunyai 3 divisi yaitu Administrasi, Operasional dan Marketing. Divisi Admisnistrasi menangani semua pembukuan, akuntansi dan aktivitas kesekretariatan di dalam perusahaan. Divisi Operasional terdiri dari kegiatan bengkel dan kegiatan spare part dalam menyediakan item untuk kendaaraan yang akan melakukan servis ke Agung Toyota Tabanan. Divisi Marketing menangani pemasaran mobil baru. Divisi Operasional, khususnya pada bagian spare part, selalu mengalami permasalahan yaitu tidak bisa secara rutin mengendalikan persediaan part non moving sesuai dengan target yang sudah ditetapkan oleh induk perusahaan. Masalah ini terjadi disebabkan adanya beberapa persediaan part non moving memiliki frekuensi permintaan yang tinggi hingga melebihi batas maksimal permintaan terhadap part non moving. Oleh karena itu diperlukan metode FSN Analysis untuk mengendalikan persediaan part non moving demi meminimalisir terjadinya over stock. Metodologi yang digunakan pada penelitian ini adalah analisis deskriptif kuantitatif dengan melakukan pengumpulan data seperti observasi atau pengamatan, wawancara dan studi kepustakaan. Hasil penelitian menunjukkan bahwa penerapan metode FSN Analysis di Agung Toyota Tabanan terhadap persediaan spare part sangat bermanfaat dalam memandu pembelian dan pemesanan. Hal ini dapat memberikan gambaran yang jelas kepada manajemen ketika pergerakan part berubah menjadi slow moving dari kategori non moving, atau sebaliknya. Sehingga dapat membantu untuk mengkategorikan kembali dan mempertahankan tingkat persediaan yang optimal sesuai dengan pergerakan aktual part selama beberapa waktu.
Kata Kunci : Spare Part, FSN Analysis, Persediaan
PENGARUH GOOD GOVERNANCE DAN PROFITABILITAS TERHADAP TOBIN Q DENGAN ENVIRONMENTAL DISCLOSURE SEBAGAI MODERASI
Authors: Saraswati Wiwik , Yuliani Tutik , Pramudia Dimas Rama , Chuarajab Tawakkal 
Published: March 2024

Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh pengungkapan lingkungan dalam memediasi hubungan antara tata kelola dan profitabilitas terhadap nilai perusahaan pada Perusahan PROPER. Populasi dalam penelitian ini adalah seluruh perusahaan yang terdaftar di Bursa Efek Indonesia (BEI) periode 2019 sampai 2022. Sampel yang digunakan dalam penelitian ini sebanyak 540 data. Hasil penelitian ini menunjukkan bahwa mekanisme tata kelola dan profitabilitas meningkatkan nilai perusahaan artinya investor cenderung melihat mekanisme tata kelola dan profitabilitas sebagai sinyal dalam menentukan keputusan investasi. Pengungkapan lingkungan tidak dapat meningkatkan nilai perusahaan, investor tidak memandang dan pengungkapan lingkungan sebagai isu yang menarik dan dianggap tidak memiliki kandungan informasi. Hasil penelitian ini juga membuktikan bahwa tata kelola dan profitabilitas tidak dapat meningkatkan nilai perusahaan melalui pengungkapan lingkungan.
Kata Kunci: Penungkapan Lingkungan, Nilai Perusahaan, Mekanisme Tata Kelola, Profitabilitas.
A culpabilização de mães de autistas ao longo das décadas de 1940 a 1960
Authors: Lopes Bruna Alves 
Published: March 2024

O presente artigo tem como proposta analisar o processo de culpabilização das mães de autistas ao longo das décadas de 1940 a 1960. Para tal, utilizamos como fonte duas obras centrais na história do autismo, a saber: Autistic disturbances of affective contact, publicada em 1943, de autoria do psiquiatra Leo Kanner e o livro A Fortaleza Vazia, lançado em 1967 nos Estados Unidos e escrito pelo psicanalista Bruno Bettelheim
Para conhecer a Educação Histórica: um inventário da Teoria e Filosofia da História – um olhar e diferentes perspectivas
Authors: Divardim de Oliveira Thiago Augusto 
Published: March 2024

Resumo: Didática da história e educação histórica configuram domínios científicos que dialogam de diferentes maneiras com referenciais da teoria e filosofia da história, da historiografia e das ciências da educação. Progressão do pensamento histórico, processo formativo da consciência histórica e desenvolvimento de competências representam perspectivas da relação entre teoria da história e as atividades de pesquisa, ensino e aprendizagem que são indiciárias da incorporação dessas influências. O artigo propõe um inventário (GRAMSCI, 1984) traçando um olhar brasileiro, sobre diferentes perspectivas epistemológicas da Alemanha, Inglaterra e Portugal. As fontes analisadas no inventário foram produções de referência da área e que frequentemente são utilizadas em conjunto por pesquisadores brasileiros. O inventário permite perceber tradições epistemológicas distintas e alguns diálogos interdisciplinares que auxiliam na ampliação dos debates da didática da História pensada no âmbito da teoria e da própria ciência da História. Palavras-chave: didática da história; educação histórica; teoria da história. Abstract: The Didactics of history and the historical education constitute scientific domains that dialogue in different ways with references from the theory and philosophy of history, historiography and educational sciences. Progression of historical thinking, formative process of historical consciousness and the development of competencies that represent perspectives of the relationship between theory of history and research activities, teaching and learning that are indicative of the incorporation of these influences. The article proposes an inventory (GRAMSCI, 1984) drawing a Brazilian view, on different epistemological perspectives from Germany, England and Portugal. The sources analyzed in the inventory were referenced productions in the area and are often used together by Brazilian researchers. The inventory makes it possible to perceive distinct epistemological traditions and some interdisciplinary dialogues that help to broaden the debates on the Didactics of History thought within the scope of the theory and the science of History itself. Keywords: didactics of history; historical education; theory of history.
Frôr da Arta sociedade”
Authors: Rebouças Daniel 
Published: March 2024

O artigo analisa a burleta "A Frôr da Arta Sociedade", dos dramaturgos Sílio Boccanera Júnior e Alexandre Fernandes. Encenada em vários palcos do país no final do século XIX, trabalho com a hipótese da peça ter sido uma ação dos autores nos debates sobre o futuro do país sem escravidão e republicano. Usando do humor, de música e de performances racializadas para defender uma cidadania limitada, mostro, por outro lado, mostro uma polissemia na recepção pelo público das mensagens emanadas do palco.
Effects of Resveratrol on Liver Function Tests in Patients with Non-Alcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Ebrahimpour P. , Karamian M. , Sharifi A. 
Published: March 2024

Background. Some studies have shown that resveratrol may prevent, delay, or treat liver damage. This study aimed to provide up-to-date evidence regarding the effect of resveratrol on the liver enzymes (ALT & AST) in NAFLD patients. We conducted a systematic review and meta-analysis to evaluate the effect of resveratrol on liver enzymes in patients with NAFLD by searching various databases for published RCTs.Methods. A systematic search in PubMed, Scopus, and Web of Science was performed up to September 2023. This systematic review and meta-analysis included all the RCT studies assessing resveratrol supplements on serum AST and/or ALT in NAFLD patients. The effect was presented as a mean difference and 95 % confidence interval (CI) in a random-effects model.Results. Finally, six eligible randomized controlled trials consisting of 256 patients were found. Resveratrol had no significant effect on serum ALT (Mean diff = 3.30 IU/L; 95 % CI: –2.34, 8.94; p = 0.25) and AST (Mean diff = 0.07 IU/L; 95 % CI: –2.96, 3.10; p = 0.96) concentrations. Moreover, subgroup analysis revealed that neither resveratrol dose nor intervention duration had any significant effect on the serum ALT and AST levels.Conclusion. The current evidence shows that resveratrol supplementation did not affect liver enzymes in NAFLD patients.
Autoimmune Gastritis: Focus on Endoscopic and Morphological Characteristics
Authors: Kiryukhin A. P. , Tertychnyy A. S. , Pavlov P. V. , Fedorenko A. A. , Nagornaya D. P. , Marenich N. S. , Losik E. A. , Yuryeva E. Yu. , Lapina T. L. 
Published: March 2024

Aim: tosystematize the literature data on endoscopic semiotics and morphological changes in the gastric mucosa in autoimmune gastritis.Key points. Autoimmune gastritis is associated with an increased risk of developing adenocarcinoma and neuroendocrine tumours of the stomach. Clarification of diagnostic criteria for autoimmune gastritis is essential for gastroenterological practice. The diagnosis is based on the results of endoscopic and histological examination, and on data from laboratory tests. Isolated atrophy of the mucous membrane of the body of the stomach, the presence of difficult-to-wash creamy mucus, changes in the mucous membrane like “shed skin”, and the presence of whitish globule-like foci are typical endoscopic signs of autoimmune gastritis. Widespread pseudopyloric metaplasia, focal intestinal and pseudopancreatic metaplasia, hyperplasia of the ridges of the mucous membrane of the body of the stomach and their relationship to the glandular layer as in the antrum allow during a morphological study considering clinical data to suspect and verify autoimmune gastritis.Conclusion. During instrumental examination, knowledge of endoscopic symptoms and pathognomonic morphological changes is important for the timely diagnosis of autoimmune gastritis.
Modern Possibilities of Using Acotiamide in the Treatment of Functional Dyspepsia
Authors: Sheptulin A. A. , Rabotyagova Yu. S. 
Published: March 2024

Aim: to evaluate the efficacy and safety of the new prokinetic drug acotiamide in the treatment of functional dyspepsia.Key findings. Acotiamide is an antagonist of inhibitory muscarinic receptors of type 1 and 2 and a reversible inhibitor of acetylcholinesterase activity. In patients with functional dyspepsia acotiamide normalizes the accommodation of the fundal part of the stomach and accelerates delayed gastric emptying. The conducted studies have confirmed the higher efficacy of acotiamide compared to placebo in reducing the severity of such symptoms of functional dyspepsia as a feeling of epigastric postprandial fullness and bloating, early satiation. The advantage of acotiamide in comparison to other prokinetics (in particular, metoclopramide and domperidone) is the high safety of use and the absence of influence on the duration of the Q-T interval.Conclusion. The high efficacy and safety of the application makes it advisable to use acotiamide in the treatment of patients with functional dyspepsia.
Diagnostic and Prognostic Value of Hyperammonemia in Patients with Liver Cirrhosis, Hepatic Encephalopathy, and Sarcopenia (Experts’ Agreement)
Authors: Nadinskaia M. Yu. , Maevskaya M. V. , Bakulin I. G. , Bessonova E. N. , Bueverov A. O. , Zharkova M. S. , Okovityi S. V. , Ostrovskaya A. S. , Gulyaeva K. A. , Ivashkin V. T. 
Published: March 2024

Introduction. In cirrhotic patients, hyperammonemia develops due to impaired ammonia detoxification and portosystemic blood shunting and is most commonly associated with hepatic encephalopathy and sarcopenia. Currently, there are questions regarding the diagnosis of hyperammonemia and the effect of ammonia-lowering therapy on disease outcomes.Materials and methods. The Russian Scientific Liver Society selected a panel of seven experts in liver cirrhosis research and management of patients with this disease to make reasoned statements and recommendations on the issue of diagnostic and prognostic value of hyperammonemia in patients with liver cirrhosis, hepatic encephalopathy and sarcopenia.Results. The Delphi panel identified the most relevant topics, in the form of PICO questions (patient or population, intervention, comparison, outcome). The Delphi panel made six questions relevant to clinical practice and gave reasoned answers, framed as ‘clinical practice recommendations and statements’ with evidence-based comments. The questions and statements were based on the search and critical analysis of medical literature by keywords in Englishand Russian-language databases. The formulated questions could be combined into four categories: hepatic encephalopathy, sarcopenia, hyperammonemia, and ammonia-lowering therapy.Conclusions. The results of the experts' work are directly relevant to the quality management of patients with liver cirrhosis, and their recommendations and statements can be used in clinical practice.
Pengaruh pembelajaran daring terhadap motivasi dan hasil belajar PAI
Authors: Pratiwi Dewi , Wahdah Nurul , Anshari Muhammad Redha 
Published: March 2024

Penelitian ini bertujuan untuk mengetahui bentuk pengaruh pembelajaran daring terhadap motivasi dan hasil belajar PAI siswa. Penelitian ini telah dilaksanakan pada bulan Maret sampai Mei 2021. Metode dalam penelitian ini adalah menggunakan metode expost facto. Teknik pengambilan sampel dalam penelitian ini adalah menggunakan teknik proportonate strafied random sampling. Instrumen dalam penelitian ini menggunakan kuesioner tertutup dengan bentuk skala likert dan dokumentasi. Teknik analisis data yang digunakan dalam penelitian ini korelasi product moment, korelasi rank spearman, dan koefisien determinasi. Hasil perhitungan ini adalah dengan program SPSS 25 Berdasarkan hasil penelitian menunjukkan bahwa dari data perhitungan, disimpulkan bahwa: (1) Pembelajaran daring siswa dengan nilai rata-rata dengan nilai 3,358 termasuk kategori tinggi. (2) Motivasi siswa dengan nilai rata-rata dengan nilai 3,790 termasuk kategori tinggi. (3) Hasil belajar PAI siswa dengan nilai rata-rata dengan nilai 84,9 termasuk kategori tinggi. (4) Ada pengaruh yang signifikan antara pembelajaran daring terhadap motivasi siswa dengan nilai uji koefisen determinasi yaitu 11,8%. Jadi, Ho ditolak dan Ha diterima (5) Tidak ada pengaruh antara pembelajaran daring terhadap hasil belajar PAI siswa. Hal ini terbukti dari koefisen determinasi yaitu 0,044%. Jadi, Ho diterima dan Ha ditolak. Kata Kunci: Pengaruh, Pembelajaran Daring, Motivasi, Hasil Belajar
The Meaning of The Miare Tradition: From Condolences to The Symbolisation of The Corps in The Grave
Authors: Mualimin Mualimin , Rofi'i Rofi'i 
Published: March 2024

This article aims to analyse the meaning of Miare tradition for the community in Makrampai village, Sambas Regency. This study is a qualitative research with a phenomenological approach. Data were obtained by conducting in-depth interviews and participant observation. Data collection was conducted in Makrampai Village from April to September 2021. The data were then analysed using an interactive qualitative analysis model: data reduction, data display, and conclusion. This study found two essential meanings of the miare tradition for the Makrampai village community. First, the miare tradition manifests condolences and social solidarity towards members of the society who have suffered calamities, especially death. Second, the Miare tradition is a reminder and advice that every human being will definitely face death in the cycle of life. Keywords: Miare Tradition; Makrampai Village; Condolences; Death