bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of ferritin genes in Parkinson disease
Authors: Foglieni Barbara , Ferrari Francesca , Goldwurm Stefano , Santambrogio Paolo , Castiglioni Emanuela , Sessa Maria , Antonietta Volontè Maria , Lalli Stefania , Galli Carlo , Wang Xin-Sheng , Connor James , Sironi Francesca , Canesi Margherita , Biasiotto Giorgio , Pezzoli Gianni , Levi Sonia , Ferrari Maurizio , Arosio Paolo , Cremonesi Laura 
Published: October 2007

AbstractClin Chem Lab Med 2007;45:1450–6.
Association of a 27-bp repeat polymorphism in intron 4 of endothelial constitutive nitric oxide synthase gene with myocardial infarction in Tunisian patients
Authors: Jemaa Riadh , Kallel Amani , Ben Ali Samir , Omar Souheil , Chabrak Sonia , Elasmi Monia , Haj Taieb Sameh , Sanhaji Haïfa , Feki Moncef , Mechmeche Rachid , Kaabachi Naziha 
Published: October 2007

AbstractClin Chem Lab Med 2007;45:1476–80.
Multimers and adiponectin gene 276G>T polymorphism in the Japanese population residing in rural areas
Authors: Ishibashi Kiyomi , Takamura Noboru , Aoyagi Kiyoshi , Yamasaki Hironori , Abiru Norio , Nakazato Mio , Kamihira Shimeru , Maeda Takahiro 
Published: October 2007

AbstractClin Chem Lab Med 2007;45:1457–63.
Impact of rosiglitazone on the expression of β3-AR in the stable cell lines expressed β3-AR gene
Authors: Zhao Xin , Hu Min-Yu , Huang Qiong , Tang Zhong-Yang , Dai Xing-Ping , Yin Ji-Ye , Zhang Feng , Zhou Hong-Hao , Liu Zhao-Qian 
Published: October 2007

AbstractClin Chem Lab Med 2007;45:1511–6.
Altered angiogenesis in preeclampsia: evaluation of a new test system for measuring placental growth factor
Authors: Schmidt Markus , Dogan Canan , Birdir Cahid , Callies Rainer , Kuhn Ulrich , Gellhaus Alexandra , Janetzko Alfred , Kimmig Rainer , Kasimir-Bauer Sabine 
Published: October 2007

AbstractClin Chem Lab Med 2007;45:1504–10.
Utility of PFA-100® closure time vs. optical aggregometry in assessing the efficacy of platelet membrane glycoprotein IIb/IIIa antagonists in vitro
Authors: Stegnar Mojca , Božič Mojca , Dolenc Marija Sollner , Anderluh Petra Štefanič , Kikelj Danijel 
Published: October 2007

AbstractClin Chem Lab Med 2007;45:1542–8.
Current state and future directions of neurochemical biomarkers for Alzheimer's disease
Authors: de Jong Daniëlle , Kremer Berry P.H. , Olde Rikkert Marcel G.M. , Verbeek Marcel M. 
Published: October 2007

AbstractIn this comprehensive review, we summarize the current state-of-the-art of neurochemical biomarkers for Alzheimer's disease. Predominantly, these biomarkers comprise cerebrospinal fluid biomarkers directly related to the pathophysiology of this disorder (such as amyloid β protein, tau protein). We particularly pay attention to the innovations in this area that have been made in technological aspects during the past 5 years (e.g., multiplex analysis of biomarkers, proteomics), to the discovery of novel, potential biomarkers (e.g., amyloid β oligomers, isoprostanes), and to the extension of this research towards identification of biomarkers in plasma.Clin Chem Lab Med 2007;45:1421–34.
Use of SELDI-TOF mass spectrometry for identification of new biomarkers: potential and limitations
Authors: Kiehntopf Michael , Siegmund Robert , Deufel Thomas 
Published: October 2007

AbstractSurface-enhanced laser desorption time of flight mass spectrometry (SELDI-TOF-MS) is an important proteomic technology that is immediately available for the high throughput analysis of complex protein samples. Over the last few years, several studies have demonstrated that comparative protein profiling using SELDI-TOF-MS breaks new ground in diagnostic protein analysis particularly with regard to the identification of novel biomarkers. Importantly, researchers have acquired a better understanding also of the limitations of this technology and various pitfalls in biomarker discovery. Bearing these in mind, great emphasis must be placed on the development of rigorous standards and quality control procedures for the pre-analytical as well as the analytical phase and subsequent bioinformatics applied to analysis of the data. To avoid the risk of false-significant results studies must be designed carefully and control groups accurately selected. In addition, appropriate tools, already established for analysis of highly complex microarray data, need to be applied to protein profiling data. To validate the significance of any candidate biomarker derived from pilot studies in appropriately designed prospective multi-center studies is mandatory; reproducibility of the clinical results must be shown over time and in different diagnostic settings. SELDI-TOF-MS-based studies that are in compliance with these requirements are now required; only a few have been published so far. In the meantime, further evaluation and optimization of both technique and marker validation strategies are called for before MS-based proteomic algorithms can be translated into routine laboratory testing.Clin Chem Lab Med 2007;45:1435–49.
Parieto-Frontal Connectivity during Visually Guided Grasping
Authors: Grol Meike J. , Majdandz̆ić Jasminka , Stephan Klaas E. , Verhagen Lennart , Dijkerman H. Chris , Bekkering Harold , Verstraten Frans A. J. , Toni Ivan 
Published: October 2007

Grasping an object requires processing visuospatial information about the extrinsic features (spatial location) and intrinsic features (size, shape, orientation) of the object. Accordingly, manual prehension has been subdivided into a reach component, guiding the hand toward the object on the basis of its extrinsic features, and a grasp component, preshaping the fingers around the center of mass of the object on the basis of its intrinsic features. In neural terms, this distinction has been linked to a dedicated dorsomedial “reaching” circuit and a dorsolateral “grasping” circuit that process extrinsic and intrinsic features, linking occipital areas via parietal regions with the dorsal and ventral premotor cortex, respectively. We have tested an alternative possibility, namely that the relative contribution of the two circuits is related to the degree of on-line control required by the prehension movement.We used dynamic causal modeling of functional magnetic resonance imaging time series to assess how parieto-frontal connectivity is modulated by planning and executing prehension movements toward objects of different size and width. This experimental manipulation evoked different movements, with different planning and execution phases for the different objects. Crucially, grasping large objects increased inter-regional couplings within the dorsomedial circuit, whereas grasping small objects increased the effective connectivity of a mainly dorsolateral circuit, with a degree of overlap between these circuits. These results argue against the presence of dedicated cerebral circuits for reaching and grasping, suggesting that the contributions of the dorsolateral and the dorsomedial circuits are a function of the degree of on-line control required by the movement.
Radical Change and Wikis: Teaching New Literacies
Authors: Luce‐Kapler Rebecca 
Published: October 2007

By using Radical Change texts and wikis—online, open‐source, Web‐creation software—the researcher in this study anticipated that students would create “e‐literature” that would have interesting hyperlinks, both with other students' texts and throughout the story. Instead, the students did very little connecting, wrote small fragments of text, and relied primarily on images to “tell” a story.Nevertheless, during the interviews, the researcher found that the students had developed some visual literacy skills, and she identified four teaching practices that were important for engaging students in literacy processes:
focusing events
interacting in groups
enabling constraints
playing opportunities
Examining Ways Readers Engage With Websites During Think‐Aloud Sessions
Authors: Damico James , Baildon Mark 
Published: October 2007

Findings from this study of how two pairs of eighth‐grade students each transacted with a website during think‐aloud sessions at the conclusion of a curricular unit on Mexico and migration highlight the ways the students engaged in three interrelated tasks:
Identifying and making sense of “new” information
Evaluating claims and evidence
Considering ways to use the site in the writing of their own narrative
While these findings represent ways that these students demonstrated proficiency with literacy practices in beginning to read websites in more disciplined and disciplinary ways, they also point to two key challenges: contextualizing and corroborating sources of information and setting purposes for reading websites in a dynamic learning context.
Strategy Instruction During Word Study and Interactive Writing Activities
Authors: Williams Cheri , Lundstrom Ruth P. 
Published: October 2007

In this project, a teacher researcher and a university researcher used qualitative data collection and analysis procedures to collaboratively investigate the efficacy of interactive writing as a context for guided practice in the use of specific spelling strategies that had been taught during daily word study lessons. The researchers also examined first‐grade, Title I children's use of those strategies during independent writing events.Findings of the project indicated that the teacher researcher taught a number of fundamental spelling strategies during word study instruction, which were categorized as Tools of the Trade and Tools of the Mind. Results also demonstrated the ways in which interactive writing provided meaningful opportunities for the teacher to scaffold the children's use of the strategies that were taught. Finally, the project suggested that students appropriated a number of those strategies and used them independently during writing activities in the regular classroom. The project supports the use of both word study and interactive writing instruction in the early literacy program.
Insights From Teachers Who Analyzed Transcripts of Their Own Classroom Discussions
Authors: Kucan Linda 
Published: October 2007

Transcript analysis is a way for teachers to engage in inquiry on their own practice. The insights of three teachers who engaged in transcript analysis of their own classroom discussions are described in this article.The teachers analyzed and reflected on their transcripts using a coding manual and a comparison and reflection guide. The coding manual provided labels for coding the kinds of questions and teacher responses that occurred during the teachers' text‐based discussions. The comparison and reflection guide guided the teachers in organizing their data and invited them to reflect on text selection, decisions about where to stop in the text to pose a question, kinds of questions that supported student effort in developing an understanding of text ideas, and kinds of responses to students that extended students' thinking.
Overlapping Vocabulary and Comprehension: Context Clues Complement Semantic Gradients
Authors: Greenwood Scott C. , Flanigan Kevin 
Published: October 2007

Despite the clear and longstanding connection between meaning vocabulary and reading comprehension, programs designed to teach vocabulary have often had surprisingly little impact on overall reading ability. One possible reason for this small effect is that teaching methods may not make this vocabulary‐to‐comprehension connection explicit for the students.To address this disconnect, this article describes practical tips for overlapping vocabulary and comprehension instructional methods. Specifically, the authors combined two strategies, context clues and semantic gradients, to support their graduate students as they, in turn, helped their own students examine shades of meaning among related sets of words. The purpose of overlapping these two strategies is to enable students to reconnect individual word meanings back to the text, helping them bridge the vocabulary to comprehension divide. A specific sequence of instruction is provided.
Effect of Periodontal Therapy on Pregnancy Outcome in Women Affected by Periodontitis
Authors: Tarannum Fouzia , Faizuddin Mohamed 
Published: October 2007

Background: There is convincing evidence to suggest that infections affecting the mother during pregnancy may produce alterations in the normal cytokine‐ and hormone‐regulated gestation, which could result in preterm labor, premature rupture of membranes, and preterm birth (PTB). Studies in the late 1990s associated periodontitis with preterm low birth weight (PLBW) deliveries, and this may have similar pathogenic mechanisms as other maternal infections. This study determined the effect of non‐surgical periodontal therapy on pregnancy outcome.Methods: A total of 200 pregnant women with periodontitis were randomly assigned to treatment and control groups. Detailed data about previous and current pregnancies were obtained. All women received a full‐mouth periodontal examination, including oral hygiene index‐simplified, bleeding index, and clinical attachment level. The women in the treatment group received non‐surgical periodontal therapy during the gestational period, and those in the control group received periodontal treatment after delivery. Periodontal therapy included plaque control instructions and scaling and root planing performed under local anesthesia. The outcome measures assessed were gestational age and birth weight of the infant. PTB was recorded when delivery occurred at <37 weeks of gestation, and low birth weight (LBW) was recorded when the infant weighed <2,500 g.Results: There were 53 PTBs in the treatment group and 68 PTBs in the control group. Twenty‐six LBW infants were recorded in the treatment group, and 48 LBW infants were noted in the control group. The mean gestational ages were 33.8 ± 2.8 weeks and 32.7 ± 2.8 weeks in the treatment and control groups, respectively. The difference was statistically significant at P <0.006. The mean birth weight was 2,565.3 ± 331.2 g in the treatment group and 2,459.6 ± 380.7 g in the control group, with the difference being statistically significant at P <0.044. A multiple regression model showed a significant effect of periodontal treatment on birth outcomes.Conclusions: Non‐surgical periodontal therapy can reduce the risk for preterm births in mothers who are affected by periodontitis. Additional multicentered, randomized, controlled clinical trials are required to confirm this link between periodontitis and PLBW.
Differential Expression of E‐Cadherin and Cytokeratin 19 and Net Proliferative Rate of Gingival Keratinocytes in Oral Epithelium in Periodontal Health and Disease
Authors: Nagarakanti S. , Ramya S. , Babu Praveen , Arun K.V. , Sudarsan Sabitha 
Published: October 2007

Background: The effects of periodontal disease on the oral gingival epithelium (OGE) have not been documented fully because they may not be as dramatic as those seen on the junctional epithelium. The aim of this study was to estimate the changes occurring in the OGE with respect to its proliferation and E‐cadherin and cytokeratin 19 (K19) expression during pocket formation.Methods: Gingival samples were collected from 17 periodontally healthy subjects and 18 subjects with chronic periodontitis. K19 and E‐cadherin levels were analyzed immunohistochemically. The net proliferative rate was calculated as the difference between the proliferative rate and the apoptotic rate as determined by immunohistochemical analysis of Ki‐67 and p53, respectively.Results: There was a significant increase in the net proliferative rate of the OGE during pocket formation (periodontitis group, 220.90 ± 46.85; healthy group, 107.60 ± 25.86; P <0.001). There was a significant reduction in E‐cadherin expression (periodontitis group, 0.837 ± 0.428; healthy group, 1.846 ± 0.555) and a significant increase in K19 expression during pocket formation (periodontitis group, 1.45 ± 0.686; healthy group, 0.533 ± 0.410).Conclusion: OGE appears to undergo significant changes in proliferation and differentiation during pocket formation that do not seem to be restricted to proteolytic destruction by the invading microorganisms.
The Effect of 0.12% Chlorhexidine Gluconate Rinsing on Previously Plaque‐Free and Plaque‐Covered Surfaces: A Randomized, Controlled Clinical Trial
Authors: Zanatta Fabrício B. , Antoniazzi Raquel P. , Rösing Cassiano K. 
Published: October 2007

Background: Previous in vitro studies showed little bactericidal effect on structured oral biofilm after exposure to chlorhexidine (CHX). In vivo evidence of a CHX effect against structured biofilm is scarce. The purpose of this study was to compare the efficacy of 0.12% CHX gluconate on previously plaque‐free and plaque‐covered surfaces.Methods: This study had a single‐masked, randomized split‐mouth, 21‐day experimental gingivitis design including 20 individuals who refrained from all mechanical plaque control methods for 25 days. On day 4 of plaque accumulation, the individuals had two randomized quadrants cleaned; the other two quadrants served as the plaque‐covered surfaces. Also, on day 4, the individuals started rinsing with 0.12% CHX gluconate for 21 days. The Quigley and Hein plaque index (PI), gingival index (GI), and gingival crevicular fluid (GCF) volume were assessed at baseline and days 21 and 25. The PI also was assessed at days 4, 11, and 18.Results: Intergroup comparisons showed statistically higher PI throughout the study on the plaque‐covered surfaces compared to the plaque‐free surfaces. When the inflammatory response over time was analyzed, a statistically greater increase in GI (from 0.21 ± 0.02 to 0.93 ± 0.03 versus from 0.18 ± 0.01 to 0.52 ± 0.03 on plaque‐covered and plaque‐free surfaces, respectively) and GCF volumes (from 48.09 to 94.28 μl versus from 46.94 to 64.99 μl on plaque‐covered and plaque‐free surfaces, respectively) occurred on plaque‐covered surfaces after 21 days of plaque accumulation.Conclusions: A 0.12% CHX gluconate mouthrinse had little antiplaque and antigingivitis effect on previously plaque‐covered surfaces. These results confirm the diminished effect of CHX on structured biofilm and reinforce the necessity of biofilm disruption before the initiation of CHX mouthrinse.
Periodontal Health and Adverse Pregnancy Outcome in 3,576 Turkish Women
Authors: Toygar H. Uslu , Seydaoglu G. , Kurklu S. , Guzeldemir E. , Arpak N. 
Published: October 2007

Background: Preterm low birth weight (PLBW) is a problem encountered worldwide. The many causes of low birth weight (LBW) and premature or preterm birth (PTB) vary among developing/industrialized countries. Few studies have been published, in part because of the paucity of subjects and the ethnic heterogeneity of the populations. Our goals were to correlate maternal periodontal disease with birth outcomes in a Turkish population and evaluate maternal periodontal health.Methods: This study consisted of 3,576 Turkish women who gave birth within 24 hours of the onset of labor. The adjusted odds ratio was generated from various logistic regression models.Results: Codes from the Community Periodontal Index of Treatment Needs (CPITN) were evaluated according to treatment need (TN). The TN‐I rate was 24.2% (N = 866), the TN‐II rate was 73.5% (N = 2,628), and the TN‐III rate was 2.3% (N = 82). There were 566 (15.8%) adverse birth outcomes; the PTB with LBW rate was 4.2%; the PTB with normal birth weight (NBW) rate was 8.3%; the in term birth with LBW rate was 3.3%, and the in term birth with NBW rate was 84.2%. The overall PTB rate was 12.5% (N = 447), and the LBW rate was 7.5% (N = 269). The mean birth weight and weeks of gestation decreased as the CPITN level increased (P <0.001 for both). The LBW rate was 4.6% in the TN‐I group, 8.3% in the TN‐II group, and 14.6% in the TN‐III group. TPTB rates were 10.5%, 12.7%, and 26.8%, respectively, whereas adverse birth outcome rates were 12.0%, 16.6%, and 30.5%, respectively (P <0.01 for all). TN‐II and TN‐III were independent risk factors for LBW, PTB, and abnormal births in regression analyses.Conclusion: Maternal periodontal disease may be a risk factor for an adverse pregnancy outcome.
Intravenous Bisphosphonate–Associated Osteonecrosis of the Jaw
Authors: Statz Thomas A. , Guthmiller Janet M. , Humbert Lewis A. , Johnson Georgia K. 
Published: October 2007

Background: Bisphosphonates have received attention in the dental and medical scientific literature because of spontaneous necrosis of the jaw subsequent to their use. As the population ages, the use of these medications is increasing; the medical benefits seem to outweigh the risk for osteonecrosis of the jaw (ONJ).Methods: A 71‐year‐old white male with a history of multiple myeloma, for which he was receiving intravenous (IV) zoledronic acid, presented for routine periodontal maintenance therapy. Intraoral observation revealed a 9 × 4‐mm area of exposed bone on the lingual aspect of tooth #31. Initially, the site was treated conservatively with topical 0.12% chlorhexidine gluconate application. Over a 12‐month period, the area of exposed bone increased in size to 20 × 9 mm and became symptomatic.Results: The osseous necrosis progressed, ultimately resulting in a pathologic fracture of the right posterior mandible that was managed by reduction and stabilization. At 5 months post‐surgery, bone exposure persisted in the region, and a new site of osteonecrosis developed on the contralateral side of the jaw.Conclusions: ONJ associated with IV bisphosphonate therapy is extremely difficult to manage. Dental treatment of ONJ should be conservative and provide relief to the patient. Patients with cancer who are candidates for IV bisphosphonate therapy should be informed of the potential risks and be referred for dental evaluation. Dentists should collaborate with physicians to minimize the risk for ONJ.
Enhanced Bone Regeneration in Beagle Dogs With Bovine Bone Mineral Coated With a Synthetic Oligopeptide
Authors: Park Jun‐Beom , Lee Jue‐Yeon , Park Yoon‐Jeong , Rhee Sang‐Hoon , Lee Sang‐Cheol , Kim Tae‐Il , Seol Yang‐Jo , Lee Yong‐Moo , Ku Young , Rhyu In‐Chul , Han Soo‐Boo , Chung Chong‐Pyoung 
Published: October 2007

Background: Recombinant human bone morphogenic protein‐2 stimulates bone augmentation in animal models. The aim of this study was to evaluate the capacity of bovine bone mineral coated with synthetic oligopeptides to enhance guided bone regeneration in the beagle 3‐wall defect model and the clinical implications.Methods: The second and fourth mandibular premolars of four adult beagle dogs were extracted bilaterally, and the extraction sites were allowed to heal for 2 months. An L‐shaped defect was prepared at the central part of the extraction site with a round bur on a low‐speed motor. Peptide‐coated bone mineral was implanted on one side, and uncoated bone mineral was implanted on the other side. The membrane was tucked underneath the mobilized lingual flap. New bone formation at the test and control sites was determined at 4 weeks.Results: No specimen revealed any evidence of infection or foreign body reaction, and all wounds showed a good healing response. Sites augmented with peptide‐coated bone mineral and uncoated mineral exhibited excellent maintenance of the ridge contour. There was more new bone at sites with peptide‐coated bone mineral than at control sites. The new bone in sites with peptide‐coated bone mineral was deposited evenly around the graft material, and bone mineral was integrated fully into the new bone.Conclusion: Deproteinized cancellous bovine bone coated with synthetic oligopeptides enhanced new bone formation, and it seemed to be a better material for guided bone regeneration in the beagle L‐shaped defect model.