bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of process monitoring on beyond‐the‐job process improvements
Authors: Schedlinsky Ivo , Schmidt Maximilian , Sommer Friedrich , Wöhrmann Arnt 
Published: February 2025

AbstractAlthough it has always been important for firms that employees innovate predefined processes, the working environment in which employees implement these processes has significantly changed. Currently, the working environment is often characterized by employee surveillance; that is, the way in which employees conduct a process is monitored. In the current study, we present the results of an experiment examining the effect of process monitoring on process improvements by employees. Although previous accounting literature has reported negative effects of monitoring techniques on several organizational outcomes, we show that process monitoring can have a positive effect on employees' implementation of process improvements in the absence, but not in the presence, of a firm's error avoidance policy. Without an error avoidance policy, employees are motivated to create a favorable impression in front of management by implementing process improvements. This finding has important implications for business practice. From a broader perspective, we show that the influence of action controls depends on the parameters of a cultural control.
Spironolactone for the Treatment of Moderate to Severe Acne in Adult Women: A Systematic Review and Meta‐Analysis of Randomised Controlled Trials
Authors: Kow Chia Siang , Ramachandram Dinesh Sangarran , Hasan Syed Shahzad , Thiruchelvam Kaeshaelya 
Published: February 2025

ABSTRACTThis systematic review and meta‐analysis aimed to assess the efficacy and safety of spironolactone for moderate to severe acne in adult women by synthesising data from randomised controlled trials (RCTs). The meta‐analysis demonstrated that spironolactone significantly increased the odds of treatment success, with a pooled odds ratio (OR) of 2.51 compared to placebo or doxycycline. This analysis supports spironolactone as a highly effective treatment for moderate to severe acne in adult women, particularly in hormonally driven cases. Its efficacy, combined with its role as an alternative to long‐term antibiotic therapy, makes it a valuable option for acne management in women population.
Revisiting concepts of thermal physiology: understanding negative feedback and set‐point in mammals, birds, and lizards
Authors: Mitchell Duncan , Fuller Andrea , Snelling Edward P. , Tattersall Glenn J. , Hetem Robyn S. , Maloney Shane K. 
Published: February 2025

AbstractThe thermoregulatory system of homeothermic endotherms operates to attain thermal equilibrium, that is no net loss or gain of heat, where possible, under a thermal challenge, and not to attain a set‐point or any other target body temperature. The concept of a set‐point in homeothermic temperature regulation has been widely misinterpreted, resulting in such confusion that some thermoregulation specialists have recommended that it be abandoned. But the set‐point concept has enjoyed a resurgence in a different domain, lizard microclimate selection. We review the principles of thermoregulation in homeotherms, endorse a negative feedback system with independent set‐points for individual thermo‐effectors as its core mechanism, and address the misconceptions about homeothermic set‐point. We also explore the concept of set‐point range in lizard microclimate selection and conclude that there is substantial convergence between that concept and the set‐points of homeothermic thermo‐effectors, as thresholds. In neither homeothermic nor lizard thermoregulation is the concept of a unitary set‐point appropriate. We review the problems of measuring the set‐points for lizard microclimate selection. We do not believe that the set‐point concept in thermoregulation should be abandoned just because it has been misinterpreted by some users. It is a valid concept, identifying the threshold body temperatures at which regulatory thermo‐effectors will be activated, to aid in attaining thermal equilibrium.
Benzoyl Peroxide's Sensitisation Potential and Potency in Experimental Methods and Review of Contact Allergy and Allergic Contact Dermatitis
Authors: Egele Kerstin , Drexler Hans , Fartasch Manigé , van Kampen Vera , Merk Hans F. , Nowak Dennis , Schnuch Axel , Uter Wolfgang , Kreis Patricia , Blömeke Brunhilde 
Published: February 2025

ABSTRACTPositive patch test responses to benzoyl peroxide (BPO) have been reported from patients without and with known exposure. Up to 6.5% were found in the United States and 7.8% in a study including patients from Germany, Austria and Switzerland. We provide an overview of the skin sensitisation potential and potency of BPO based on animal experiments and non‐animal methods. BPO tested positive in Guinea Pig Tests and the Local Lymph Node Assay. Application of the current OECD guideline to identify a skin sensitizer by combining non‐animal method results gave differing outcomes. Moreover, patch test responses of patients to BPO were considered to determine the importance of BPO as a relevant occupational contact allergen. Another well‐known BPO exposure is the topical application to treat acne. Despite widespread use, extensive and long‐term skin exposure, we found for this group only studies reporting few positive patch test reactions. Further, occupational handling of BPO and contact allergy is reported by dental technicians. In‐depth evaluation of the prevalence of contact allergy in different professions with suspected BPO exposure did not reveal an association with occupational handling of BPO. Consequently, a generally increased risk for those professions is not supported.
Pharmacogenetic Information on Drug Labels of the Italian Agency of Medicines (AIFA): Actionability and Comparison Across Other Regulatory Agencies
Authors: Moschella Antonino , Mourou Soumaya , Perfler Samantha , Zoroddu Enrico , Bezzini Daiana , Soru Dorian , Trignano Claudia , Miozzo Monica , Squassina Alessio , Cecchin Erika , Floris Matteo 
Published: February 2025

ABSTRACTTo plan future steps for the implementation and regulation of pharmacogenetic testing, any issue in the management of pharmacogenetic information by regulatory bodies must be identified. In this paper, an analysis of pharmacogenetic information in the summary of product characteristics (SmCPs) of drugs approved by Italian Drug Agency (AIFA) was conducted. Among 4214 SmCPs of 1063 active ingredients, 53.2% (n = 2240) included pharmacogenetic information in at least one section, most frequently for drugs in the Anatomical Therapeutic Chemical category “Antineoplastic and immunomodulatory agents”. To contextualize these data in the international scenario, a pharmacogenetic level of actionability, based on AIFA SmCPs, was assigned to 608 drug/gene pairs included in FDA's “Table of Pharmacogenomic Biomarkers in Drug Labels”, according to PharmGKB (The Pharmacogenomics Knowledge Base). Approximately 67% of drug/gene pairs were deemed classifiable: Based on SmCPs phrasing, for half of them the genetic testing was cataloged as “required” or “recommended” (mainly tumor somatic variants), whereas 40% as “actionable” (mostly PK/PD‐related germline variants). The comparison with other regulatory agencies highlighted a discordance in the assigned pharmacogenetic levels of actionability ranging from 1% to 14%. This discrepancy may also point out the need to rethink the language used in AIFA‐approved SmCPs to clarify whether a pharmacogenetic test is necessary or not and for which subjects it has been recommended. For the first time, a detailed evaluation and comparative analysis of the pharmacogenetic information on Italian SmCPs was presented, placing it in an international context and laying the groundwork for rethinking pharmacogenetic indications in AIFA‐approved SmCPs.
How to amend the EU Treaties? Legal ways and deadlocks
Authors: Ritleng Dominique 
Published: February 2025

AbstractThe EU Treaties revision procedures have been conceived according to a federal design. That prompts the making of the following recommendations as to how to amend the EU Treaties:
treaty revision must follow the specific amendment procedures of Article 48 TEU. Amending EU Treaties through Article 49 TEU‐based agreements is not legally feasible.
each treaty amendment recommended by the Group of Twelve must be classified under the proper revision procedure.
the shift from the ‘double unanimity’ requirement to a four‐fifths majority for treaty change should be made but without Member States being thereby bound by treaty revisions, they have not agreed.
WoodAD: A New Dataset and a Comparison of Deep Learning Approaches for Wood Anomaly Detection
Authors: del‐Tejo‐Catala Omar , Perez Javier , Garcia Nicolas , Perez‐Cortes Juan‐Carlos , Del Ser Javier 
Published: February 2025

ABSTRACTAnomaly detection is a crucial task in computer vision, with applications ranging from quality control to security monitoring, among many others. Recent technological advancements have enabled near‐perfect solutions on benchmark datasets like MVTec, raising the need for novel datasets that pose new challenges for this modelling task. This work presents a novel Wood Anomaly Detection (WoodAD) dataset, which includes defects in wooden pieces that result in challenges for the most advanced techniques applied to other established datasets. This article evaluates such challenges posed by WoodAD with one‐class and few‐shot supervised learning approaches. Our experiments herein reveal that EfficientAD, a state‐of‐the‐art method previously excelling on the MVTec dataset, outperforms all other one‐class learning approaches. Nevertheless, there is room for improvement, as EfficientAD achieves a 0.535 pixel/segmentation average precision (AP) over the complete test set. UNet, a well‐known pixel‐level classification architecture, leveraged few‐shot supervised learning to enhance the pixel AP score, achieving 0.862 pixel/segmentation AP over the entire test set. Our WoodAD dataset represents a valuable contribution to the field of anomaly detection, offering complex image textures and challenging defects. Researchers and practitioners are encouraged to leverage this dataset to push the boundaries of anomaly detection and develop more robust and effective solutions for more complex real‐world applications. The WoodAD dataset has been made publicly available in Kaggle (https://www.kaggle.com/datasets/itiresearch/wood‐anomaly‐detection‐one‐class‐classification).
Novel Creep–Fatigue Interaction Model Based on Kitagawa–Takahashi and a Probabilistic Creep Pore Model
Authors: Nguyen Tuan Duc , Jordan Oliver , Maede Lucas , Beck Tilmann , Kulawinski Dirk 
Published: February 2025

ABSTRACTThe Kitagawa–Takahashi (KT) diagram and the El Haddad equation are widely used to predict the allowable stress range for an internal defect size . This approach discriminates between regions designating nonpropagation and propagation of short and long cracks. However, the KT diagram is incapable of describing the damage under creep conditions, as in that case, the assumption of a time‐independent threshold for fatigue crack propagation is invalid and must be considered as time dependent. The proposed Kitagawa–Takahashi with creep (KTC) method combines pore size distributions predicted by a probabilistic creep pore model with the El Haddad equation. This new approach is suitable to characterize the interaction of creep–fatigue loading. Within this work, modified Wöhler and Haigh diagrams for creep–fatigue at various temperatures are presented and validated with creep–fatigue experiments as well as high‐cycle fatigue (HCF) tests on precrept specimens made from the polycrystalline nickel‐base superalloy 247.
Feasibility and Applicability of Implementing the Framework for Comprehensive Understanding of Structural Stigma in Mental Healthcare Systems: A Case Example of Nepal
Authors: Gurung Dristy , Subedi Bhawana , Acharya Binita , Neupane Mani , Kohrt Brandon A. , Thornicroft Graham , Gronholm Petra C. 
Published: February 2025

ABSTRACTIntroductionMental health‐related structural stigma is a multifaceted issue that significantly impacts access to quality mental healthcare, particularly in low‐resource settings like Nepal. Therefore, there is a clear need to understand the complexities and identify gaps for targeted interventions through evaluations of various dimensions of structural stigma within healthcare systems. This study aimed to assess the feasibility and applicability of a mental health‐related structural stigma measurement framework through its implementation in Nepal's healthcare system.MethodsA mixed‐methods approach was employed, involving data mapping, key informant interviews and rating exercises with diverse stakeholders, including policymakers, health workers and people with lived experience (PWLEs). A visual analogue scale or Red/Amber/Green (RAG) rating scale was used to rate each indicator within the framework for the level of structural stigma based on the mapped information and their experiences. Data collection was carried out from May to June 2024.ResultsTwenty key informants were interviewed for this exercise. Most indicators within the framework were endorsed as yellow, followed by red by participants referring to mid to high levels of structural stigma within the healthcare system. The findings also revealed that the stakeholders perceived the framework as acceptable and applicable for measuring mental health‐related structural stigma in the healthcare system. However, challenges were noted regarding the clarity of some indicators, limitations of the three‐coloured visual analogue rating and the need for comparator conditions.ConclusionThe study underscores the measurement framework's value as a tool for identifying and addressing structural stigma in a mental healthcare system in a low‐resource setting. Stakeholder engagement and contextual adaptation are crucial for its successful implementation. The insights gained can inform structural reforms and improve mental health service delivery, ultimately promoting greater equity and access for PWLEs.Patient Public ContributionThis framework being assessed in this study (FOCUS‐MHS) was developed through extensive consultation with People with Lived Experiences (PWLEs) in Nepal and globally with the Global Mental Health Peer Network along with other stakeholders. Identification of documents, policies and studies, along with qualitative information mapped within the indicators, was informed by PWLEs involved in local study sites and by policymakers and health administrators. The reflections of the study participants—PWLEs, health administrators and policymakers, have guided further refinement of the framework for future use.
The usefulness of transarterial embolization before transurethral resection of bladder tumor for patients with large bladder tumors
Authors: Yamada Yusuke , Taguchi Motohiro , Shimatani Kimihiro , Yanagi Toeki , Kanematsu Akihiro , Kako Yasukazu , Takaki Haruyuki , Yamakado Koichiro , Yamasaki Takashi , Hirota Seiichi , Yamamoto Shingo 
Published: February 2025

ObjectiveTo assess the usefulness of transarterial embolization (TAE) before a transurethral resection of bladder tumor (TURBT) procedure for large bladder tumors, intra‐ and postoperative outcomes were retrospectively compared between patients with and without TAE before TURBT.Methods and resultsThirty‐seven patients underwent TURBT for complete resection of bladder tumors with a diameter of 3 cm or greater between January 2013 and December 2023 at the Department of Urology, Hyogo Medical University. For 13, TAE was performed 1 or 2 days before TURBT. In the TAE group, tumor volume was significantly larger [74.1 ± 42.7 (28.9–190.5) cm3 vs. 17.3 ± 14.3 (6.1–69.8) cm3, p < 0.05] and operative time significantly shorter [119 ± 49.8 (74–263) min vs. 143 ± 28.1 (107–218) min, p = 0.012] as compared with the non‐TAE group. Furthermore, the change in hemoglobin level was significantly less in the TAE group [−0.6 ± 0.8 (0.4 to −2.3) mg/dL vs. −1.0 ± 0.7 (0.1 to −3.1) mg/dL, p = 0.008].ConclusionTAE before TURBT for a large bladder tumor contributes to less blood loss and shorter operative time, thus allowing resection to be performed safely without serious complications.
The Postapocalyptic Frontier Hero: The (Weird) Western, Cowboy Masculinity, and Regenerative Violence in The Last of Us (2013)
Authors: Pereira Teresa 
Published: February 2025

ABSTRACTThe following article argues that Naughty Dog's The Last of Us is a Weird Western that, despite imaginatively reinventing the Western genre by setting it in a near‐future, postapocalyptic United States, reiterates many of its core tenets. Among these are the inclusion of a cowboy‐like, white, male hero, namely the game's protagonist, Joel Miller, and the depiction of gruesome violence as both regenerative and justified. To conduct this analysis, the article adopts a cultural studies perspective, bringing together different disciplines that engage in the field of American studies, namely literary criticism, film studies, gender studies, and game studies, while also relying heavily on Bogost's concept of procedural rhetoric.
Understanding Health Literacy in Fluid Management in Individuals Receiving Haemodialysis: A Directed Qualitative Content Analysis
Authors: Chen Chen , Zheng Jing , Liu Xu , Liu Jiali , Xie Yeli , Shi Shuna , You Liming 
Published: February 2025

ABSTRACTAimsTo describe the perspectives of individuals receiving haemodialysis regarding health literacy in fluid management.DesignA qualitative descriptive approach using directed content analysis of interviews from an explanatory mixed methods study.MethodsSemi‐structured individual interviews were conducted from September 2020 to February 2021 with 28 individuals receiving haemodialysis who had attended a prior quantitative study. A directed qualitative content analysis approach was used to identify categories and subcategories emerging from the data.ResultsSix categories of health literacy were identified: (1) active health management, (2) engagement with healthcare providers, (3) understanding and support from healthcare providers, (4) social support, (5) health information literacy and (6) navigation of the healthcare system.ConclusionsBased on their real‐life experience, individuals receiving haemodialysis have unique health literacy needs regarding fluid management. A comprehensive understanding of these unique needs is crucial in creating person‐centered interventions to address inadequate fluid restriction.Implications for the Profession and/or Patient CareInterventions to address inadequate fluid restriction should be person‐centered, considering each individual's unique health literacy needs. This involves conducting a comprehensive assessment of individuals' health literacy needs, empowering individuals to actively engage in health, engaging the entire support network and facilitating health information literacy in line with individuals' preferences.ImpactThis study offers detailed insights into the health literacy needs related to fluid management in individuals undergoing haemodialysis. The findings could inform the development of person‐centered fluid management strategies for these individuals.Reporting MethodWe adhered to the Consolidated Criteria for Reporting Qualitative Research checklist.Patient or Public ContributionNo patient or public contribution.
Are we playing the same “research” game in business?
Authors: Fairbanks Joshua C. , Winters Drew B. 
Published: February 2025

AbstractThis study evaluates the limitations of impact factors in assessing journal quality and explores the competitive dynamics of publishing in top‐tier journals across Accounting, Finance, Management, and Marketing. We document notable cross‐disciplinary variations that challenge the effectiveness of impact factors. Our findings suggest that expanding journal lists within business disciplines by adding high‐impact journals can change the competitiveness of top‐tier publications and may lead to imbalances in promotion and tenure (P&T) decisions. This study contributes to the broader discussion on journal quality metrics in business research, advocating for a nuanced approach to achieve fair and accurate assessments across disciplines.
Factors Affecting Healthcare Professionals' Decision‐Making Around Parenteral Nutrition in Advanced Cancer: A Systematic Review
Authors: McCracken Jennifer , Bajwah Sabrina , Shaw Clare 
Published: February 2025

ABSTRACTBackgroundMany factors beyond clinical guidelines may influence healthcare professionals' (HCPs) decision‐making. This systematic review aims to identify the factors that affect HCPs decision‐making around parenteral nutrition (PN) in advanced cancer.MethodsA literature search was conducted by May 2023 via MEDLINE, Embase, PsycINFO, The Cochrane Library, CINAHL, PubMed, Web of Knowledge and PROSPERO. Fourteen additional papers were identified. Two reviewers independently screened all papers with consensus reached on inclusion. Three reviewers conducted quality appraisal independently. Reference checking and citation tracking were completed for all included papers.ResultsOf 458 papers identified, 5 papers met the eligibility criteria (3 online surveys, 2 qualitative studies). All papers were European. Papers were published between 2020 and 2023. Six themes were identified as affecting decision‐making: clinical indications, quality of life, hope, the multidisciplinary team, barriers to facilitating home PN and the influence of relatives. Performance status was a commonly considered indicator of suitability for home PN. PN is more common for people with advanced cancer and intestinal failure (IF) in the UK. Barriers to providing PN included unclear clinical indication, colleague objections, lack of local expertise and poor communication between HCPs.ConclusionCollaborative working and effective communication are essential between acute services, IF centres and community services to facilitate decision‐making around PN in advanced cancer. It is important for HCPs to set realistic expectations. Communication must be sensitive to the patient's values and culture.
Spray‐induced gene silencing to control plant pathogenic fungi: A step‐by‐step guide
Authors: Mosquera Sandra , Ginésy Mireille , Bocos‐Asenjo Irene Teresa , Amin Huma , Diez‐Hermano Sergio , Diez Julio Javier , Niño‐Sánchez Jonatan 
Published: February 2025

ABSTRACTRNA interference (RNAi)‐based control technologies are gaining popularity as potential alternatives to synthetic fungicides in the ongoing effort to manage plant pathogenic fungi. Among these methods, spray‐induced gene silencing (SIGS) emerges as particularly promising due to its convenience and feasibility for development. This approach is a new technology for plant disease management, in which double‐stranded RNAs (dsRNAs) targeting essential or virulence genes are applied to plants or plant products and subsequently absorbed by plant pathogens, triggering a gene silencing effect and the inhibition of the infection process. Spray‐induced gene silencing has demonstrated efficacy in laboratory settings against various fungal pathogens. However, as research progressed from the laboratory to the greenhouse and field environments, novel challenges arose, such as ensuring the stability of dsRNAs and their effective delivery to fungal targets. Here, we provide a practical guide to SIGS for the control of plant pathogenic fungi. This guide outlines the essential steps and considerations needed for designing and assessing dsRNA molecules. It also addresses key challenges inherent to SIGS, including delivery and stability of dsRNA molecules, and how nanoencapsulation of dsRNAs can aid in overcoming these obstacles. Additionally, the guide underscores existing knowledge gaps that warrant further research and aims to provide assistance to researchers, especially those new to the field, encouraging the advancement of SIGS for the control of a broad range of fungal pathogens.