bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Documentation of Firearm Access During Pediatric Emergency Visits for Suicidal Ideation
Authors: Kemal Samaa , Lennon Tyler , Simon Norma-Jean , Kaczor Kim , Hilliard Mallory , Corboy Jacqueline B. , Hoffmann Jennifer A. 
Published: March 2024

BACKGROUND AND OBJECTIVES
Approximately half of youth suicides involve firearms. The promotion of safe firearm storage in the home through lethal means counseling reduces suicide risk. We aimed to increase the documentation of firearm access and storage among children presenting to the emergency department (ED) with suicidal ideation or self-injury to 80% within 13 months.

METHODS
We conducted a multidisciplinary quality improvement initiative to improve the documentation of firearm access and storage among children &lt;18 years old seen in the ED for suicidal ideation or self-injury. The baseline period was February 2020 to September 2021, and interventions occurred through October 2022. Interventions included adding a templated phrase about firearm access to psychiatric social work consult notes and the subsequent modification of the note to include all firearm storage elements (ie, locked, unloaded, separate from ammunition). Statistical process control and run charts were generated monthly to monitor the documentation of firearm access and storage, which was measured through a review of keyword snippets extracted from note text.

RESULTS
We identified 2158 ED encounters for suicidal ideation or self-injury during the baseline and intervention periods. Documentation of firearm access increased from 37.8% to 81.6%, resulting in a centerline shift. Among families who endorsed firearm access, the documentation of firearm storage practices increased from 50.0% to 78.0%, resulting in a centerline shift.

CONCLUSIONS
The modification of note templates facilitated increased documentation of firearm access and storage practices for children with suicidal ideation in the ED. Future studies should assess whether improved documentation is associated with improved storage practices and reductions in firearm suicides after ED encounters.
Allergic rhinitis: therapeutic strategies update Lactococcus lactis Plasma and tranilast–roxithromycin combination
Authors: Horiuchi Yasuhiro 
Published: March 2024

* At present, there is no established definitive and reliable therapy for allergic rhinitis.
* Combined effects of tranilast, which inhibits mast cell degranulation, and a specific macrolide antibiotic, roxithromycin, which has T helper 2 (Th2) cell inhibitory effects through ligands and receptors, may aid significantly in managing allergic rhinitis.
* Lactococcus lactis strain Plasma (LC-Plasma) can induce plasmacytoid dendritic cells and consistent intake of LC-Plasma increases T helper 1 (Th1) responses, indicating a potential to suppress Th2 hypersensitivity conditions, such as allergic rhinitis.
* A novel treatment approach for hay fever can now be chosen based on to the severity of the disease and amount of scattered pollen.
Clinical and economic effectiveness of using immunotherapeutic drugs in patients with urothelial carcinoma in the healthcare system of the Russian Federation
Authors: Krysanov I. S. , Makarova E. V. , Kurkin D. V. , Ermakova V. Yu. 
Published: March 2024

Aim. To perform pharmacoeconomic evaluation of chemotherapy schemes GC (gemcitabine, cisplatin) and GemCarbo (gemcitabine, carboplatin) in comparison with immunotherapy drugs atezolizumab, pembrolizumab or avelumab in patients with locally advanced or metastatic urothelial carcinoma.Materials and methods. Pharmacoeconomic cost–effectiveness analysis, sensitivity analysis in context of changes of initial model parameters were performed.Results. Literature data analysis allows to make a conclusion of better clinical effectiveness and safety of immunotherapy drugs compared to chemotherapy in patients with urothelial carcinoma. Cost of medications was significantly lower for platinum-based chemotherapy (103,625.61 rubles for GC and 88,733.63 rubles for GemCarbo) compared to a course of immunotherapy (950,092.39 rubles for atezolizumab, 953,340.21 rubles for pembrolizumab, 1,328,999.43 rubles for GC + avelumab). However, the cost of treatment of complications arising during platinum-based chemotherapy was more than 20-fold higher than cost of treatment of immunotherapy complications: 578,853.02 rubles versus 15,336.78– 26,994.52 rubles). Cost–effectiveness analysis favored atezolizumab for which cost–effectiveness ratio was 53,230.69 rubles for 1 month of patient’s life. Atezolizumab had better value than standard 1st line GC chemotherapy by 10,671.80 rubles, as well as immunotherapy courses using pembrolizumab by 9,697.57 rubles and GC + avelumab by 10,824.66 rubles. The highest costs were observed for GemCarbo chemotherapy course: it is 18,522.82 rubles more expensive than atezolizumab course. Sensitivity analysis performed for the cost–effectiveness ratio showed stability of the developed model in regards to increased cost of atezolizumab course up to +18 % and decrease in overall survival with this course up to –15 %.Conclusion. Atezolizumab is a clinically effective and economically justified option for treatment of adults with locally advanced or metastatic urothelial carcinoma and PD-L1 expression ≥5 % in the healthcare system of the Russian Federation.
Atypical neoplastic solitary focal uptake of 18F-PSMA-1007 in PET/CT in patients with biochemically recurrent prostate cancer
Authors: Antonevskaya T. L. , Khalimon A. I. , Khodzhibekova M. M. , Atakishieva L. U. , Khamadeeva G. F. , Khodakova D. Yu. , Lazutina T. N. , Pylova I. V. , Volchenko N. N. , Leontyev A. V. 
Published: March 2024

It is established that prostate-specific membrane antigen (PSMA), despite its name, is expressed in many tissues other than the prostate gland, both within physiological conditions and in various pathological processes. Additionally, apart from prostate cancer, other malignant tumors are characterized by increased PSMA expression which, according to many authors, is associated with neoangiogenesis. These factors are reflected in the results of PSMA-radioligand imaging and require comprehensive approach to image interpretation including evaluation of computed tomography and magnetic resonance semiotics. In addition, rare cases of distant visceral prostate cancer metastasis in the form of solitary lesions also should be considered during interpretation of the results of radiologic imaging including positron emission tomography/computed tomography.We present two clinical cases in which positron emission tomography/computed tomography revealed solitary foci of pathological 18F-PSMA-1007 uptake outside the areas of typical metastatic spread (with exception of advanced disease) of prostate cancer, specifically in the stomach wall and the left cerebellar hemisphere. In the first case histological examination results revealed a metachronous low grade neuroendocrine tumor of the stomach, in the second case a metastatic lesion of the cerebellum was diagnosed as part of the underlying disease.
Functional outcomes of repeat kidney resection in patients with cancer recurrence after nephron-sparing surgeries
Authors: Zhumabaev N. K. , Komarov M. I. , Klimov A. V. , Matveev V. B. , Stilidi I. S. 
Published: March 2024

Aim. To perform comparative analysis of functional outcomes of repeat kidney resection and radical nephrectomy in patients with local cancer recurrence after previous organ-sparing surgeries.Materials and methods. Data on 64 patients who underwent surgical treatment at the Oncourology Department of the N.N. Blokhin National Medical Research Center of Oncology between 2000 and 2022 due to local kidney cancer recurrence after previous nephron-sparing surgeries were retrospectively and prospectively included in the study. Among these, 37 (57.8 %) patients underwent repeat kidney resection (treatment group) and 27 (42.2 %) patients underwent radical nephrectomy (control group). The groups were matched in demographic and clinical characteristics (р >0.05). Median diameter of recurrent tumor in the treatment and control groups was 2.5 and 3.0 cm, respectively (95 % confidence interval 2.0–3.0 cm; Q1–Q3 2.4–4.0 cm). This difference was statistically significant (р = 0.012), but not clinically. Median follow-up duration was 35 (3–131) months (Q1–Q3 13–57 months).Results. Repeat nephron-sparing surgeries correlated with lower decrease in kidney function compared to organ-resecting surgical treatment. In the early postoperative period, decrease in calculated glomerular filtration rate per the CKD-EPI formula compared to baseline after re-resection and nephrectomy was 16 and 32 % (р = 0.010); long-term, it was 8 ± 41 and 45 ± 22 % (р <0.001), respectively. Complication rates in the groups were similar: 21.6 and 29.6 %, respectively (р = 0.563).Conclusion. For local kidney cancer recurrence, repeat resection promotes preservation of kidney function without increased complication rate.
Biosimilars in the practice of modern oncologist
Authors: Shevchuk I. M. , Kalpinskiy A. S. 
Published: March 2024

Currently, genetically engineered drugs are widely used in oncological clinical practice which has significantly increased treatment cost. One of the most effective ways to decrease cost is substitution of an innovative drug after patent expiration with a reproduced compound – biosimilar.In this article, a problem of biosimilars is actualized both worldwide and in Russia, characteristics of these products are described, and the path of the agents from the moment of reproduction through preclinical and clinical trials to introduction into real clinical practice is traced, examples of such trials are presented.The results of clinical trials of effectiveness and safety of Pembroria® in patients with various oncological pathologies are described in detail. The first data from the multicenter prospective post-marketing trial PERFECTION are presented demonstrating similar effectiveness and tolerability results for the biosimilar in a multicohort patient category compared to pembrolizumab molecule.Manufacturing of high-quality analogs and their introduction into clinical practice create a possibility to provide more patients in need with modern highly effective and safe drugs as well as increases effectiveness of the state healthcare system.
First experience of using Pembroria® medication in patients with disseminated renal cell carcinoma
Authors: Shevchuk I. M. , Movchan N. D. 
Published: March 2024

Background. According to the clinical guidelines from the leading Russian and international societies, treatment of patients with metastatic renal cell carcinoma is based on combination use of immune and targeted drugs. In December of 2022, the first Russian analogue of immune-oncological drug pembrolizumab with trade name Pembroria® was registered in Russia.Aim. To evaluate safety of the biosimilar, as well as register its effectiveness in the form of objective response estimation in accordance with the RECIST v.1.1 (Response Evaluation Criteria in Solid Tumors version 1.1) criteria. The article presents the results of the first experience of using Pembroria® in real clinical practice. Two clinical observations are presented demonstrating effectiveness and safety of the biosimilar.Materials and methods. At the clinic of the N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiology Center, 21 patients with clear cell renal cell carcinoma who did not previously receive systemic antitumor treatment underwent immunotarget therapy with Pembroria® and a targeted agent: lenvatinib (20 mg/day orally) or axitinib (10 mg/day orally).Results. The analysis of effectiveness considering short follow-up periods was performed in 18 patients. Median follow-up period was 6 (2–13) months and objective response rate was 50 %, in 28 % of cases stable disease was observed. Survival rates were not evaluated due to short observation time.Conclusion. Use of Pembroria® medication in patients with metastatic renal cell carcinoma in real clinical practice showed high objective response rate with acceptable toxicity level. No new, previously not described adverse events were registered during Pembroria® administration.
Robot-assisted radical prostatectomy in patients after endoscopic surgeries on the prostate
Authors: Guliev B. G. , Ilyin D. M. , Kharchenko P. V. , Talyshinskiy A. E. , Krylov O. A. 
Published: March 2024

Background. In literature, data on the results of robot-assisted radical prostatectomy (RARP) in patients after transurethral resection of the prostate (TURP) are contradictory.Aim. To evaluate surgical, functional, and oncological outcomes of RARP after TURP.Materials and methods. At the Urology Center of the Mariinsky Hospital (Saint Petersburg), RARP was performed on 410 patients. Among them, 28 (6.8 %) patients (1st group) previously underwent TURP due to infravesical obstruction. Among them, 18 (64.3 %) patients were diagnosed with prostate cancer after pathomorphological examination of the tissue resected during TURP, and on them RARP was performed on average 3.2 months later. In 10 (35.7 %) patients, prostate cancer was diagnosed during transrectal biopsy due to increased prostate-specific antigen level; on them RARP was performed on average 42.0 months after TURP. The following parameters were evaluated: operative time, time of bladder neck reconstruction and urethrovesical anastomosis formation, blood loss volume, tumor pathological stage, Gleason score, surgical margin status, rates of urine continence and preservation of erectile function.Results. Mean operative time was higher in the 1st group compared to the 2nd: 210 ± 36 min versus 180 ± 25 min (р <0.0001). In the 1st group compared to the 2nd, reconstruction of bladder neck was necessary more frequently (82.1 % versus 10.7 %; р <0.0001), urethrovesical anastomosis took longer time (32 ± 2.3 min versus 24.5 ± 3.1 min; р <0.0001), mean blood loss volume was higher (240 ± 39 mL versus 170 ± 32 mL; р <0.0001). Frequencies of positive surgical margin were 14.3 and 10.7 % respectively in the 1st and 2nd groups (р = 0.840). Frequencies of all complications were 28.6 and 21.4 %, respectively. Severe complications (≥IIIb grade per the Clavien classification) were observed in 2 (7.1 %) patients in both groups. Frequency of anastomosis stricture after surgery was significantly higher in the 1st group: in 2 (7.1 %) and 1 (3.6 %) case, respectively (р <0.05). In the 1st group, total urinary continence was achieved in 14 (50.0 %), 20 (71.5 %), 22 (78.5 %) and 25 (89.3 %) patients at early and 3-, 6and 12-month follow-up after RARP; in the 2nd group, it was achieved in 18 (64.3 %), 22 (78.6 %), 24 (85.7 %) and 26 (92.9 %) patients in the same follow-up periods. After 6 and 12 months, in the 1st group among 15 (53.6 %) patients with normal initial erectile function, satisfactory erectile function was preserved in 46.7 and 93.3 % of patients; in the 2nd group among 19 (67.8 %) patients, in 57.8 and 94.7 % patients, respectively.Conclusion. RARP after TURP is a relatively complicated surgical intervention with long operative time and high blood loss volume. However, functional and short-term oncological outcomes of RARP in these patients do not differ at 12 months.
Analysis of the availability of bronchodilators and anti-inflammatory drugs for patients with chronic obstructive pulmonary disease
Authors: Orlova E. A. , Petrov V. I. , Dorfman I. P. , Shatalova O. V. , Orlov M. A. 
Published: March 2024

Background. The study of drug availability for patients with chronic obstructive pulmonary disease (COPD) represents one of the priority tasks in the organization of effective counteraction to COPD in the Russian Federation.Objective: to assess drug prices, affordability, and availability for COPD patients.Material and methods. The analysis of drug availability for COPD patients was carried out according to the methodology of the World Health Organization and Health Action International (WHO/HAI). Bronchodilator and anti-inflammatory therapy of originator brands and lowestpriced generics was evaluated. The consumption volume of the studied drugs was also analyzed using the ATC/DDD (Anatomical Therapeutic Chemical classification / defined daily dose) pharmacoepidemiologic methodology over a three-year period (from 2020 to 2022), taking into account their share of total DDD (drug utilization analysis, DU90%).Results. According to the results of DU90% analysis, the most purchased drugs for bronchodilator and anti-inflammatory therapy for all the years under study were drugs from the groups of short-acting bronchodilators (salbutamol, fenoterol, ipratropium bromide + fenoterol) and inhaled glucocorticoids (budesonide, beclomethasone). The obtained data were confirmed by the results of the physical availability study. Thus, the highest percentage of physical availability was for short-acting inhaled beta-2-agonists (SABA) (salbutamol). Analysis of drug affordability also revealed a tendential superiority of SABA and short-acting anticholinergics over baseline bronchodilators and antiinflammatory drugs.Conclusion. Low affordability of the main drugs of baseline therapy contributes to the burden of COPD and necessitates improvement of drug supply mechanisms for individuals, especially those with low material income, which in the long term will significantly reduce the costs of the healthcare system for the treatment of these patients by decreasing the severity and frequency of exacerbations.
Regional Planning for Aging in Place: Older Adults' Perceptions of Needs and Awareness of Aging Services in Washington State
Authors: Bolkan Cory , Weaver Raven H. , Kim Eunsaem , Mandal Bidisha 
Published: March 2024

AbstractAging in place (AIP), or being able to maintain independence in one's home and community, will be a big challenge for older adults in coming decades. As interest in AIP, age‐friendly policies, and livable community initiatives grows, successful policy planning should be based on the perspectives of older adults, especially those from marginalized communities with limited resources. We surveyed 252 community‐dwelling older adults (M = 73.61; SD = 8.44) via computer‐assisted‐telephone interviews about their health, support needs, access to services/supports, and awareness of the local aging services organization. Nearly one‐third of participants (31%) reported having unmet support needs for their activities of daily living. The most prevalent unmet needs were related to home maintenance tasks (i.e., home repairs, yard work, housekeeping, and other services). Regression analyses revealed that poor health (physical and mental) increased risk for unmet needs, but adequate knowledge of aging services lowered the risk (all p < 0.05). Most participants were not familiar with the local aging services organization and nearly one‐quarter did not know where to get the help they needed. Content analysis revealed four pathways of anticipated help: (1) reliance on friends/family, (2) general expectations that government, social services, or community support will be available, (3) pursuit of non‐specific searches for support, and (4) referrals from medical professionals. Raising awareness about affordable community‐based aging services, bolstering cross‐sector engagement, and proactively investing in age‐friendly community initiatives are necessary actions toward effectively planning for future support needs and addressing the comprehensive AIP needs of diverse older adults.
Evaluation of Sports Achievements of Participants in Cheerleading Competitions by Rationalizing Refereeing
Authors: Synytsya Tetiana , Synytsya Sergiy , Rybalko Lina , Kornosenko Oksana , Zhamardiy Valeriy 
Published: March 2024

Cheerleading is a popular sport that is developing and increasing the number of fans. Cheerleading is a subjective sport and therefore it requires a lot of attention. The aim of the study is to investigate, identify and scientifically substantiate effective ways of rationalizing the refereeing of cheerleading competitions. 105 cheerleading judges took part in the study. Based on the results of the survey, an experimental group of judges of II and III categories was formed, which consisted of 73 young judges (hereinafter referred to as novice judges), who were involved in the experiment. Among them, 35.6% have the II judge category, 64.4% – III. Among novice judges, 23.3% have 3 years of experience as judges, 42.5% – 2 years, the rest – 31.2% – 1 year. The conducted questionnaire of cheerleading judges showed that certain difficulties arise in the judging process: distraction of own athletes and their parents, judges or competition organizers (72.6%); a large number of athletes in the team (up to 24), a significant number of numbers in one nomination (11.0%); long and loud music (8.2%); violation of hygiene requirements (weak or significant lighting, unventilated room, draft, etc.) (8.2%). In addition, there is a need to store the performances in memory, for a qualitative assessment of all competitive performances. As a result of the conducted research, methodical recommendations were developed, as well as developed evaluation symbols and marks for use during competition that will help judges to qualitatively and fairly evaluate competitive performances; remember performances and correctly distribute participants.
Lightweight equivariant model for efficient interatomic potential
predictions
Authors: Shen Lei , Yang Ziduo , Wang Xian , Li Yifan , Lv Qiujie , Chen Calvin 
Published: March 2024

Abstract

In modern computational materials science, deep learning has shown the capability to predict interatomic potentials, thereby supporting and accelerating conventional simulations. However,
existing models typically sacrifice either accuracy or efficiency. Moreover, lightweight models are highly demanded for offering simulating systems on a considerably larger scale at reduced computational costs. Here, we introduce a lightweight equivariant interaction graph neural network (LEIGNN) that can enable accurate and efficient interatomic potential and force predictions for molecules and crystals. Rather than relying on higher-order representations, LEIGNN employs a scalar-vector dual representation to encode equivariant features. By extracting both local and global structures from vector representations and learning geometric symmetry information, our
model remains lightweight while ensuring prediction accuracy and robustness through the equivariance. Our results show that LEIGNN consistently outperforms the prediction performance of the representative baselines and achieves significant efficiency across diverse datasets, which include catalysts, molecules, and organic isomers. Finally, we conduct a comparative analysis of LEIGNN against both classical molecular dynamics (MD) and ab initio MD simulations across solid, liquid, and gas systems. It is found that LEIGNN can achieve the accuracy of ab initio MD and retain the computational efficiency of classical MD across all examined systems, demonstrating its accuracy, efficiency, and universality.