bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of delayed treatment for sexually transmitted infections and its determinants in sub-Saharan Africa. A systematic review and meta-analysis
Authors: Agimas Muluken Chanie , Solomon Milkias , Shewaye Daniel Alayu , Abebaw Angaw Dessie , Derseh Nebiyu Mekonnen 
Published: March 2024

Background
Sexually transmitted infection is a common public health issue, and it is characteristically transmitted through sexual intercourse. Around the globe, particularly in less developed countries, delayed treatment of this infection could lead to a health and economic burden. Even though the health and economic burden of sexually transmitted infections is high, studies to identify the pooled proportion and the possible factor of delayed treatment seeking are rare in sub-Saharan African countries.

Objective
To assess the prevalence of delayed treatment for STIs and its determinants in sub-Saharan African countries.

Method
Articles searched on search engines like Medline via PubMed, HINARI, Embase, Scopus, Cochrane Library, Science Direct, and websites like Google Scholar. The searching mechanism was using keywords and medical subject heading terms by combining the key terms of the title. To assure the quality of the included articles, Joana Brigg’s Institute critical appraisal checklist was used. To assess the heterogeneity of the studies, a sensitivity analysis was conducted. The PRISMA checklist was used, and to estimate the pooled odds ratio, a random effect model was considered. The pooled odds ratio of 95% CL was used to identify the factors.

Results
About 13 studies with 46,722 participants were incorporated. Despite considerable heterogeneity, the pooled prevalence of delayed treatment for STI in Sub-Saharan Africa was 47% (95% CI: 42%–51%, I2 = 98.42, p<0.001). Geographically, the higher pooled prevalence of delayed treatment for STI was in the eastern part of Africa (50%) (95% CI: 41%–59%, I2 = 98.42, p<0.001). Rural residence (OR = 1.44, 95% CI: 1.03–2.01, I2 = 39.3%, p-value = 0.19), poor knowledge about STI (OR = 1.49, 95% CI: 1.04–2.13, I2 = 93.1%, p-value = <0.001), perceived as STIs not serious (OR = 2.1, 95% CI: 1.86–2.36, I2 = 73.7%, p-value = 0.022), misconception for STD cause (OR = 1.39, 95% CI: 1.12–1.72), no education (OR = 4.1, 95% CI: 3.4–5.1), primary education (OR = 3.17, 95% CI: 2.23–4.2), and secondary education (OR = 1.57, 95% CI: 1.1–2.76) as compared to secondary and above education were factors associated with delayed treatment for STIs.

Conclusion
The pooled prevalence of delayed treatment for STIs in Sub-Saharan African countries was high. Poor knowledge, attitude, and educational status affect the treatment delay for STIs. Thus, improving knowledge, educational status, and attitude are highly recommended to reduce the delayed treatment of STIs.
Human-Prosthetic Interaction (HumanIT): A study protocol for a clinical trial evaluating brain neuroplasticity and functional performance after lower limb loss
Authors: Lathouwers Elke , Tassignon Bruno , Maricot Alexandre , Radwan Ahmed , Naeyaert Maarten , Raeymaekers Hubert , Van Schuerbeek Peter , Sunaert Stefan , De Mey Johan , De Pauw Kevin 
Published: March 2024

Background
Lower limb amputation contributes to structural and functional brain alterations, adversely affecting gait, balance, and overall quality of life. Therefore, selecting an appropriate prosthetic ankle is critical in enhancing the well-being of these individuals. Despite the availability of various prostheses, their impact on brain neuroplasticity remains poorly understood.

Objectives
The primary objective is to examine differences in the degree of brain neuroplasticity using magnetic resonance imaging (MRI) between individuals wearing a new passive ankle prosthesis with an articulated ankle joint and a standard passive prosthesis, and to examine changes in brain neuroplasticity within these two prosthetic groups. The second objective is to investigate the influence of prosthetic type on walking performance and quality of life. The final objective is to determine whether the type of prosthesis induces differences in the walking movement pattern.

Methods
Participants with a unilateral transtibial amputation will follow a 24-week protocol. Prior to rehabilitation, baseline MRI scans will be performed, followed by allocation to the intervention arms and commencement of rehabilitation. After 12 weeks, baseline functional performance tests and a quality of life questionnaire will be administered. At the end of the 24-week period, participants will undergo the same MRI scans, functional performance tests and questionnaire to evaluate any changes. A control group of able-bodied individuals will be included for comparative analysis.

Conclusion
This study aims to unravel the differences in brain neuroplasticity and prosthesis type in patients with a unilateral transtibial amputation and provide insights into the therapeutic benefits of prosthetic devices. The findings could validate the therapeutic benefits of more advanced lower limb prostheses, potentially leading to a societal impact ultimately improving the quality of life for individuals with lower limb amputation.

Trial registration
NCT05818410 (Clinicaltrials.gov).
Association between adverse childhood experiences and self-reported health-risk behaviors among cancer survivors: A population-based study
Authors: Sarkar Sayantani , Jackson Brianna , Manzo Laura L. , Jeon Sangchoon , Poghosyan Hermine 
Published: March 2024

Aims
Existing evidence shows that people who report Adverse Childhood Experiences (ACEs) are more likely to exhibit health-risk behaviors. However, limited research on this topic pertains to oncology population. We aim to address this knowledge gap by estimating the prevalence of ACEs and investigating their association with self-reported health-risk behaviors among adult cancer survivors living in the U.S.

Methods
We conducted a secondary analysis using cross-sectional data from the 2021 Behavioral Risk Factor Surveillance System ACE module. We included 4,126 adults, aged ≥18 years, with a history of cancer. The outcome variable was self-reported health-risk behaviors, which included cigarette smoking, e-cigarette use, and binge alcohol drinking. Self-reported ACEs history was the primary independent variable, comprised of 11 questions regarding child abuse and dysfunctional households. We conducted descriptive statistics and multivariable logistic regression to describe the relationship between the ACE history and health-risk behaviors.

Results
Overall, 84.2% of cancer survivors self-reported as White, 58.4% were women, and 76.6% were aged 65+ years. Nearly two-thirds of the sample (63.2%) self-reported at least one ACE (prior to age 18) and 21.7% engaged in ≥1 health-risk-behaviors, such as cigarette smoking, binge alcohol drinking, or e-cigarette use. Experiencing ≥3 ACEs was associated with 145% increased odds of reporting at least one health-risk behavior (OR = 2.45, 95% CI [1.78–3.38]) when compared to those without a history of ACEs. Besides, survivors who were younger, divorced, less educated, and had low income had higher odds of reporting at least one health-risk behavior.

Conclusions
Overall, a history of ACEs is associated with health-risk behaviors. These all can negatively impact cancer survivors’ overall well-being. Early screening for ACE during oncologic visits can be a protective measure for preventing health-risk behaviors among cancer survivors.
A quantitative comparison between the mHand Adapt passive adjustable hand prosthesis and its predecessor, the Delft Self-Grasping Hand
Authors: Krinis Spyros L. L. , Chadwell Alix , Kenney Laurence , Smit Gerwin 
Published: March 2024

Introduction
The Delft Self-Grasping Hand (SGH) is an adjustable passive hand prosthesis that relies on wrist flexion to adjust the aperture of its grasp. The mechanism requires engagement of the contralateral hand meaning that hand is not available for other tasks. A commercialised version of this prosthesis, known as the mHand Adapt, includes a new release mechanism, which avoids the need to press a release button, and changes to the hand shape. This study is the first of its kind to compare two passive adjustable hand prostheses on the basis of quantitative scoring and contralateral hand involvement.

Methods
10 anatomically intact participants were asked to perform the Southampton Hand Assessment Procedure (SHAP) with the mHand. Functionality and contralateral hand involvement were recorded and compared against SGH data originating from a previous trial involving a nearly identical testing regime.

Results
mHand exhibited higher functionality scores and less contralateral hand interaction time, especially during release-aiding interactions. Additionally, a wider range of tasks could be completed using the mHand than the SGH.

Discussion
Geometric changes make the mHand more capable of manipulating smaller objects. The altered locking mechanism means some tasks can be performed without any contralateral hand involvement and a higher number of tasks do not require contralateral involvement when releasing. Some participants struggled with achieving a good initial grip due to the inability to tighten the grasp once already formed.

Conclusion
The mHand offers the user higher functionality scores with less contralateral hand interaction time and the ability to perform a wider range of tasks. However, there are some design trade-offs which may make it slightly harder to learn to use.
The role of GAPDH in the selective toxicity of CNP in melanoma cells
Authors: von Montfort Claudia , Aplak Elif , Ebbert Lara , Wenzel Chantal-Kristin , Klahm Niklas P. , Stahl Wilhelm , Brenneisen Peter 
Published: March 2024

Background
Malignant melanoma is the most aggressive form of skin cancer with a rather poor prognosis. Standard chemotherapy often results in severe side effects on normal (healthy) cells finally being difficult to tolerate for the patients. Shown by us earlier, cerium oxide nanoparticles (CNP, nanoceria) selectively killed A375 melanoma cells while not being cytotoxic at identical concentrations on non-cancerous cells. In conclusion, the redox-active CNP exhibited both prooxidative as well as antioxidative properties. In that context, CNP induced mitochondrial dysfunction in the studied melanoma cells via generation of reactive oxygene species (primarily hydrogen peroxide (H2O2)), but that does not account for 100% of the toxicity.

Aim
Cancer cells often show an increased glycolytic rate (Warburg effect), therefore we focused on CNP mediated changes of the glucose metabolism.

Results
It has been shown before that glyceraldehyde 3-phosphate dehydrogenase (GAPDH) activity is regulated via oxidation of a cysteine in the active center of the enzyme with a subsequent loss of activity. Upon CNP treatment, formation of cellular lactate and GAPDH activity were significantly lowered. The treatment of melanoma cells and melanocytes with the GAPDH inhibitor heptelidic acid (HA) decreased viability to a much higher extent in the cancer cells than in the studied normal (healthy) cells, highlighting and supporting the important role of GAPDH in cancer cells.

Conclusion
We identified glyceraldehyde 3-phosphate dehydrogenase (GAPDH) as a target protein for CNP mediated thiol oxidation.
Emotion recognition and social functioning in individuals with autism spectrum condition and intellectual disability
Authors: Tamas Daniela , Brkic Jovanovic Nina , Stojkov Stanka , Cvijanović Danijela , Meinhardt–Injac Bozana 
Published: March 2024

Objective
Most previous studies have examined emotion recognition in autism spectrum condition (ASC) without intellectual disability (ID). However, ASC and ID co-occur to a high degree. The main aims of the study were to examine emotion recognition in individuals with ASC and co-occurring intellectual disability (ASC-ID) as compared to individuals with ID alone, and to investigate the relationship between emotion recognition and social functioning.

Methods
The sample consisted of 30 adult participants with ASC-ID and a comparison group of 29 participants with ID. Emotion recognition was assessed by the facial emotions test, while. social functioning was assessed by the social responsiveness scale–second edition (SRS-2).

Results
The accuracy of emotion recognition was significantly lower in individuals with ASC-ID compared to the control group with ID, especially when it came to identifying angry and fearful emotions. Participants with ASC-ID exhibited more pronounced difficulties in social functioning compared to those with ID, and there was a significant negative correlation between emotion recognition and social functioning. However, emotion recognition accounted for only 8% of the variability observed in social functioning.

Conclusion
Our data indicate severe difficulties in the social-perceptual domain and in everyday social functioning in individuals with ASC-ID.
Intermolecular interactions, spectroscopic and theoretical investigation of 4-aminoacetophenone
Authors: Rocha Mariana , Di Santo Alejandro , Ben Altabef Aida , M. Gil Diego 
Published: March 2024

The molecular structure of 4-aminoacetophenone (PAAP) was determined by DFT calculations using different basis sets. The structural parameters, electronic properties and vibrational wavenumbrers of the optimized geometry have been determined. The vibrational wave-numbers of the fundamental modes of the title compound have been precisely assigned and analyzed and the theoretical results are compared with the experimental vibrations observing a very good correlation. TD-DFT approach was applied to assign the electronic transitions ob-served in the experimental UV-vis spectrum. The molecular electrostatic potential map was used to identify the possible electrophilic and nucleophilic sites. Natural bond orbital (NBO) analysis and atoms in molecules (AIM) approach are applied in order to quantify the relative strength of hydrogen bonding interactions and to account their effect on the stabilities of molecular arrangements. In addition, a detailed exploration of the intermolecular interactions that stabilizes the crystal packing has been performed by using the Hirshfeld surface analysis.Â Â Â
Effect of hydrogen ion concentration and adsorbent dosage on the removal of heavy metals from metal scrap effluents using activated carbon from African palm fruit
Authors: Abdullahi Zalihat , Hussaini Kamaludeen , Abdulrazak Sani , Hashimu Yau Abdulwahab 
Published: March 2024

This study details the production of activated carbon from African palm fruit and subsequent treatment of heavy metals; Cadmium, Copper, Nickel, and Lead in wastewater effluent with the produced activated carbon from a metal scrap market in the heart of Kaduna state, Nigeria, which constitutes high level of pollution in the environment. Hydrogen ion concentration and adsorbent dosage were determined on water treatment quality using Atomic Absorption Spectrophotometer (AAS). The produced activated carbon showed a significant ability in removing heavy metals; Cadmium, Copper, Nickel, and Lead from samples of the wastewater. Higher efficiencies were observed with increase in adsorbent dosage (99.73 Â± 0.265, 95.96 Â± 0.053, 99.91 Â± 0.085, and 95.12 Â± 0.035 % at 2.5 g for Cadmium, Copper, Nickel, and Lead, respectively) and at a pH of 6 (99.61 Â± 0.182 and 80.31 Â± 0.015 % for Cadmium and Lead, respectively) and at a pH of 8 ( 99.79 Â± 0.201 and 99.73 Â± 0.252 for copper and nickel respectively). This findings show that African palm fruit can be utilized to produce activated carbon used in removal heavy metals from effluent water, representing an effective means of utilizing agricultural residues and also an alternative to the expensive commercial activated carbon.Â Â
Pengembangan Aktivitas pada Desmos Guna Memfasilitasi dalam Memahami Konsep Himpunan Penyelesaian
Authors: Botta Elfrida Eufraziana , Setiawan Yohanes Agung , Deskania Imelda Ceria , Apriani Maria Suci 
Published: March 2024

Peneliti mendapati sebuah masalah matematika pada peserta didik dalam pemahaman konsep di materi program linier. Oleh karena itu, peneliti mencari solusi agar pemahaman konsep peserta didik pada materi program linier dapat teratasi. Pada penelitian ini peneliti menawarkan solusi berupa media pembelajaran materi program linear berbasis aplikasi Desmos. Penelitian ini merupakan penelitian pengembangan yang mengikuti metode ADDIE: Analisis, Desain, Pengembangan, Implementasi, dan Evaluasi. Sementara itu dalam pengumpulan data pada penelitian ini dilakukan dengan wawancara tidak terstruktur kepada beberapa siswa dan guru kelas XI SMA. Hasil validasi terhadap produk dilakukan oleh beberapa para ahli, dihasilkan dengan ahli yang pertama yaitu ahli materi menilai 75 persen dengan hasil produk dikategorikan valid serta pada ahli media menilai juga 71 persen produk yang dikembangkan memiliki kategori valid. Selain itu, menurut penilaian siswa yang telah menggunakan produk mengungkapkan bahwa produk yang dihasilkan sebesar 83 persen dikatakan praktis.
Aufgabenprofile im Wandel: Bibliotheken in der Nationalen Forschungsdateninfrastruktur
Authors: Kurzawe Daniel , Stein Regine 
Published: March 2024

Zusammenfassung
Wissenschaftliche Bibliotheken messen sich in der digitalen Welt mit einer Vielzahl von und auch global agierenden Informationsinfrastrukturen. Die mit der Digitalisierung einhergehenden neuen Nutzungswege und Anforderungen bringen eine umfassende Weiterentwicklung ihrer Aufgaben und Angebote mit sich. Als Infrastruktur- und Innovationspartnerinnen nehmen Bibliotheken dabei eine wichtige Rolle in der Nationalen Forschungsdateninfrastruktur (NFDI) ein.
Chemical composition and bioactivities of the methanol root extracts of Saussurea costus
Authors: Binobead Manal Abdulaziz , Aziz Ibrahim M. , Ibrahim Sobhy M. , Aljowaie Reem M. 
Published: March 2024

Abstract

Saussurea costus (S. costus) is a medicinal plant from the Asteraceae family that is widely used in traditional medicine in Saudi Arabia. This study examines S. costus root extract for its chemical composition and its antioxidant, anti-cancer, and antibacterial properties. The results of the study on the methanol root extract of S. costus reveal a rich chemical composition, as identified by GC-MS/FID analysis. The extract also showed high levels of total phenolic content (188.2 ± 2.1 mg GAE/g DM) and total flavonoid content (129 ± 2.6 mg QE/g DM). In antioxidant tests, the extract exhibited strong activity, with the half-maximal inhibitory concentration (IC50) values of 137.15 μg/mL for ABTS and 175.5 μg/mL for DPPH as compared to positive control’s IC50 values of 45.5 ± 0.3 μg/mL for ABTS and 55.3 ± 0.1 μg/mL for DPPH. The cytotoxic assessment against MCF-7 and A549 cell lines showed notable effects, particularly at higher concentrations. Additionally, the extract induced apoptosis in these cell lines, evidenced by changes in gene expression. Antibacterial tests revealed significant activity against various strains, with MIC values ranging from 7.81 to 125 μg/mL. The study underscores the importance of plant extracts in modern healthcare and suggests future research directions, including clinical applications and compound identification.
Revisiting Grudin’s eight challenges for developers of groupware technologies 30 years later
Authors: Duckert Melanie , Bjørn Pernille 
Published: March 2024

AbstractIn 1994, Jonathan Grudin wrote his famous paper Eight Challenges for Groupware Developers; The question is whether these challenges still persist, or have we moved on here 30 years later? We revisit the challenges empirically through ethnographic observations in two companies examining their work practices, organizational structure, and cooperative setups concerning their use of groupware technologies. Today, groupware is seamlessly integrated into organizations, considered essential infrastructure that becomes part of the daily work routine. Contextualizing the original challenges proposed by Grudin, we categorize them into cooperative challenges, social challenges, and organizational challenges, and refine their phrasings to reflect present and future considerations faced by developers of groupware technologies. While the main arguments of the social and organizational challenges remain consistent, we rephrase the cooperative challenges asemergent exception handlingandexaggerated accessibilityto reflect the emerging characteristics associated with the ubiquity and seamless integration of groupware.
Time to initiation of adjuvant chemotherapy and survival in patients with stage II and III rectal cancer not receiving total neoadjuvant therapy
Authors: Huai Siyuan , Zhao Xuanzhu , Wang Shuyuan , Li Hongzhou , Yuan Zhen , Pang Wenwen , Wang Wanting , Han Qiurong , Yao Yao , Chu Tianhao , Feng Zhiqiang , Liu Yanfei , Yan Suying , Jin Leixin , Zhang Qinghuai , Zhang Xipeng , Dong Xuetao , Xue Jun , Zhang Chunze 
Published: March 2024

Abstract

Objectives
While the delay in adjuvant chemotherapy (AC) is known to impact colon cancer outcomes, its effect on rectal cancer is less clear. This study aims to evaluate the influence of AC timing on survival in stage II and III rectal cancer.

Methods
This retrospective multicenter study enrolled 1,144 patients receiving chemotherapy following resection of stage II–III rectal cancers. The effect of delayed AC on survival was assessed using multivariable Cox models with restricted cubic splines and logistic regression.

Results
Compared to patients initiating AC within four weeks postsurgery, those initiating within 5–8 weeks had a similar survival (HR=0.85, 95 % CI=0.66–1.11), whereas those initiating within 8–12 weeks (HR=1.62, 95 % CI=1.05–2.51) or beyond 12 weeks (HR=2.07, 95 % CI=1.21–3.56) had a significantly inferior survival. A delayed time to chemotherapy (>8 weeks) was associated with worse survival in patients aged ≥60 years but not in younger patients (<60 years: HR=1.36; 95 % CI=0.75–2.46, p=0.312; ≥60 years: HR=2.37; 95 % CI=1.56–3.60, p<0.001). Additionally, our exploratory analysis suggested that FOLFOX and FOLFIRI were more effective when starting within 5–8 weeks post-surgery, while CAPEOX and a single agent showed a slight advantage when starting within four weeks.

Conclusions
Our findings advocate for initiating AC within eight weeks post-surgery in stage II–III rectal cancer, especially in older patients. Delayed treatment is linked to significantly worse survival outcomes.
Advances in understanding comproportionation and disproportionation in nickel catalysis
Authors: Day Craig S. 
Published: March 2024

Abstract
Disproportionation and comproportionation reactions have become routinely proposed events in modern synthetic endevours that use nickel catalysts. This new found appreciation from practitioners in the field for these electron transfer reactions has largely stemmed from our improved understanding of catalytic reactions. These studies have shown evidence of the ability of nickel complexes to occupy odd and even oxidation states which are critical to dictating reactivity. Comproportionation and disproportionation reactions shuttle nickel complexes between these oxidation states and are essential to the formation of either on-cycle or off-cycle species. This review will cover these fundamental reactions, and provide information about their role in catalysis.