bluuebunny/crossref_metadata_2025_split huggingface dataset:
Most common obstacles to the quality of life of older adults in the home environment: descriptive research
Authors: Grozde Iris , Kaučič Boris Miha 
Published: February 2024

Abstract

Aim. The purpose of the research was to fi nd out what obstacles impede the provision of a quality of life in the home environment.

Material and methods. A quantitative, descriptive, non-experimental method of empirical research was used. The measurement instrument employed was a questionnaire that was completed by 110 older adults who live at home and need help with daily life activities. A non-random, convenience sample was used. The obtained data were analysed with descriptive statistics, using normal distribution and non-parametric tests.

Results. The assessment of quality of life is statistically diff erent depending on income (p = 0.001) and independent performance of daily life activities (p = 0.001). There is a statistically signifi cant association between the factors infl uencing the refusal of help by informal caregivers and family status (p = 0.032).

Conclusions. Research shows that the quality of life of older adults depends on the level of income and independent performance of daily life activities. For them, the feeling of burdening others is an obstacle to a quality stay in their home environment. In further research, it would be sensible to cover the issue of integrated long-term care and include providers and users of this type of assistance.
Factors Influencing Efficiency of Cross-Border Transport Management System Using Rfid Sensor Technology in Cross-Border Transport Management System, Nong Khai Border Checkpoint
Authors: Ayuthaya Varangkoon Issaragura Na 
Published: February 2024

Purpose: This study aimed to examine the factors influencing the efficiency of the cross-border transport management system using RFID sensor technology in the cross-border transport management system, Nong Khai border Checkpoint and develop a Structural Equation Model (SEM) for cross-border transport management system Nong Khai border Checkpoint.

Method: This study was a quantitative study. The sample group consisted of 450 cross-border logistics service providers in Thailand and used a questionnaire to collect data to analyze the data by percentage, mean, standard deviation statistics, Confirmatory Factor Analysis (CFA) and Structural Equation Model analysis (SEM).

Results and Conclusion: The research findings revealed that 1) Service and Performance variables influenced cross-border transport management system at the statistical significance level (p<.05) which was consistent with the theory. The observed variables had component weights between 0.241 to 0.79 and were significantly different from zero at the 0.01 level for 11 variables, one variable different from zero at the 0.05 level, and the reliability values. of latent variables were between 0.058 - 1.153 and 3) The harmonization of models based on assumptions and empirical data and found that all thresholds were within the acceptable (pass) criteria, Structural Equation Model analysis (Chi-Square = 44.113, df = 35, p = 0.139, RMSEA = 0.026, GFI =0.026, AGFI = 0.960).

Research Implications: In order to have satisfied or effective service level, cross-border transport management system using RFID sensor technology in Cross-border Transport Management System must have a one-stop service to fulfil all the requirement to cross the border of all vehicles every day, the service must be done in a speedy manner. For the service itself, it has to be reliable and service with equitability and adequate.

Originality/Value: This research provides the knowledge and practice for Cross-border Transport Management System, Nong Khai Border Checkpoint locating at Thailand and Laos borders to improve its facility, infrastructure as well as its service component to meet the requirement of logistics companies that use the service.
Addressing Workplace Bullying: Protecting Human Rights in The Modern Workplace
Authors: Vijayakumar Gavya , Rajagopal Subashini 
Published: February 2024

Purpose: This paper aims to highlight how crucial it is to address workplace bullying as a violation of human rights and to provide ideas for both prevention and intervention. It seeks to draw attention to the negative consequences of workplace bullying on people and organizations while also providing advice on creating a secure and welcoming workplace that supports the rights and dignity of every employee.

Methodology: The research and literature on workplace bullying, human rights concepts, and successful preventative and intervention measures are all thoroughly reviewed in this study. The data was acquired from a variety of sources, including academic research, international human rights norms, legislative frameworks, and case studies from the actual world. This data is combined to give a comprehensive picture of workplace bullying, its effects, and effective ways to deal with it.

Results: According to the study, bullying at work hurts people's physical, emotional, and psychological health as well as an organization's production, morale, and reputation. The study discusses several kinds of workplace bullying, typical bullying conduct, and its effects on people and organizations. It also emphasizes the significance of workplace human rights norms, such as the right to dignity, a secure work environment, and freedom from harassment and discrimination.

Conclusion: As a breach of human rights, workplace bullying is a major problem that has to be addressed. By implementing thorough anti-bullying policies, fostering an inclusive culture, providing accessible reporting mechanisms, providing training and education, and ensuring efficient investigation and resolution procedures, organizations can prevent and address workplace bullying.
Influence of Digital Skills on The Academic Performance of University Students: A Socioeconomic Approach
Authors: Rodríguez Ronald Floriano , Horna Richard Fermín Contreras , Placido Juana Maribel Manrique , Barbuda Julio Javier Montano 
Published: February 2024

Purpose: Analyzing the influence of digital competencies on the academic performance of university students through a socioeconomic approach.

Theoretical framework: Theories associated with digital competence, academic performance and the influence of socioeconomic factors were addressed.

Method: A mixed Ditriac-type approach was applied, with a non-experimental and cross-sectional design, where the total population was 1215 university students and the probabilistic sample for the survey was 292 students and the non-probabilistic sample for the interview was 29 students who served to collect quantitative and qualitative data respectively. Quantitative data were obtained through the COMPDIG-PED instrument of digital competence in pedagogy, whose reliability was assessed by Cronbach's Alpha coefficient α = 0.911 and academic performance was evaluated through documentary analysis of the institution's academic records, which were then processed in SPSS, and qualitative data were analyzed with Atlas.ti software considering 15 codes, 10 sub categories and 6 categories, also taking into account the socioeconomic aspect throughout the process, from the selection of participants to the interpretation of the results.

Results and conclusions: The results support a moderate degree of positive correlation of digital competencies and academic performance with an rs = 0.546 and with a significance level p = 0.000, where with respect to the coefficient of determination it is shown that digital competency influences 30.5% on the academic performance of university students, while the remaining 69.5% is affected by other socioeconomic factors. Concluding that there is positive correlation and 30.5% of influence of digital competencies with respect to academic performance, where the remaining 69.5% is due to socioeconomic factors such as educational level in parents, economic level, work, sentimental relationship and the management of time dedicated to study.

Originality/value: To provide insight into students' perceptions on the management of digital competencies and their influence on academic performance, integrating socioeconomic aspects.
P122 Unrealistic Pulse Pressures from Calibrated Tonometric Waveforms
Authors: Reesink Koen , Marais Louise , Boutouyrie Pierre 
Published: February 2024

Abstract
Background
Calibration of carotid artery tonometry waveforms needs to account for pulse pressure augmentation [1]. Due to its location nearer to the heart, carotid pulse pressure (carPP) is about 10 mmHg lower than brachial (brachPP) [1]. In practice, perfect applanation is hard to achieve with tonometry and thus tracking-errors may occur, leading to an exaggerated fall in the diastolic limb of the tonometry waveform. Consequently, the mean-to-diastolic difference of the waveform is underestimated, leading to an overestimation of carPP after calibration. We assessed the relationship between brachPP and carPP in 100 subjects, aged 18–80 yrs.

Methods and Results
Brachial pressure (Omron) and carotid tonometry (Sphygmocor) measurements were performed by a single, highly skilled vascular technician, according to Artery Society methodological standards. CarPP was 5 ± 13 mmHg lower than brachPP. Bland-Altman analysis revealed a positive trend (r = 0.695, p < 0.0001) between the carPP–brachPP difference and their mean, with carPP being 20 mmHg lower than brachPP at a mean 40 mmHg which extended to carPP being 20 mmHg higher(!) than brachPP at a mean 80 mmHg. Accordingly, 30% of the study population showed unphysiological carPP, indicating an unrealistic i.e. reverse amplification. Even with a tolerance of +5 mmHg, still 20% of cases showed unrealistic values.

Conclusion
In practice, calibrated carotid tonometry waveforms may yield unphysiological overestimations of carotid pulse pressure. This finding implies (potential) estimation errors in regression model studies on central pressure and local stiffness, suggesting brachial pulse pressure would be a valid compromise.
Acupressure to Increase Milk Production in Breastfeeding Moms
Authors: Kustiyati Sri Kustiyati , Ningrum Ari Kusuma 
Published: February 2024

Introduction: Giving acupressure therapy can increase breast milk production because it affects the stimulation process of the hormone prolactin. This study aimed to determine the effect of acupressure at points ST 15, ST 16, and Li 4 on breast milk production in postpartum mothers. Materials and Method: Type of quantitative research. Quasi-experimental research design, post-test control group research design. The sample was 32 people, 16 in the control group and 16 in the treatment group. Data processing and analysis using the SPSS application with the Mann-Whithney test. Result: The Mann-Whitney test output obtained a p-value of 0.000 (<0.05). The group of postpartum mothers who were treated produced more breast milk than the group who were not treated. Conclusion: Acupressure at points ST 15, ST 16 and, Li 4 can increase breast milk production in postpartum mothers. Midwives can perform acupressure at points ST 15, ST 16, and Li 4 on postpartum mothers to increase breast milk production.
Is Standard Music Notation Able to Picture Aristotle’s Time?
Authors: Strobach Niko 
Published: February 2024

Abstract
It is argued that standard music notation pictures Aristotle’s time (time, as Aristotle conceived of it) in a number of important respects, which concern its micro-structure. It is then argued that this allows us to see some features of Aristotle’s time more clearly. Most importantly, Aristotelian instants can be pictured by bar-lines. This allows us to see as how radically devoid of any content Aristotelian instants should be interpreted. Thus, attention to music notation may show why Aristotle was not a presentist.
Time of Change in Plato and Aristotle
Authors: Krása Ondřej 
Published: February 2024

Abstract
When do things change? When do things have some characteristics? I try to answer these questions by looking at different solutions Plato and Aristotle presented in their works. The famous analysis of change from the second half of Plato’s Parmenides claims that change happens outside of time, at an “instant”. On the contrary, Aristotle in the Physics explicitly argues that all change occurs only in time. However, both Plato and Aristotle also provide other analyses of change. How to deal with this variety of explanations and tensions between them? In this paper, I argue that if we differentiate between several kinds of change, most of Plato’s and Aristotle’s analyses provide a thorough insight into the nature of change. For processes such as locomotion, change occurs exclusively within time. For changes where both the initial and final states occur only in time, such as a transition from motion to rest, change takes place in the ‘now’. However, for changes where both the initial and final states occur in both time and in the ‘now’ – for example, a qualitative change from being white to not being white – change does not occur in time nor in the ‘now’, but instead happens instantaneously.
Are Kinetic and Temporal Continuities Real for Aristotle?
Authors: Sentesy Mark 
Published: February 2024

Abstract
Aristotle argues that time depends on soul to count it, but adds that motion, which makes time what it is, may be independent of soul. The claim that time depends on soul or mind implies that there is at least one measurable property of natural beings that exists because of the mind’s activity. This paper argues that for Aristotle time depends partly on soul, but more importantly on motion, which defines a continuum. This argument offers a robust metaphysics of time. In contrast to modern philosophy of physics, for Aristotle the continuum of motion is prior in being to time, while time is a hybrid of the real continuum of motion and the activity of mind.
Zersplitterte und gesammelte Gegenwart bei Augustinus: Das Verhältnis von physikalischer und psychologischer Zeit
Authors: Drews Friedemann 
Published: February 2024

Abstract
This paper tries to ‘liberate’ Augustine’s view on time from certain modern prejudices, e.g. that the church father’s theory of time involves the modern dichotomy between subjectivism and objectivism (Ricœur), that his understanding of time can be seen as a precursor of modern phenomenology (Husserl, Heidegger), that Conf. XI lacks a coherent theory of time as such or that, at least, it falls short of the insights of Kant’s enlightened transcendentalism (Flasch). By contrast, the church father circumvents typically modern aporiai by both differentiating between time on the level of physics and time on the level of soul as well as by accounting for the link between these two ‘times’: Whereas the time of physics tends to non–existence, it is the soul that, by cognizing a certain process in its (relative) entirety, establishes actual time; on the level of soul, time persists and is preserved (in contrast to physical time). Neither does Augustine propose nor need the notion of any ‘absolute time’. Maybe Augustine’s theory of time is compatible with certain assumptions of modern physics (e.g. Einstein’s theory of relativity) although the church fathers’ view can in no way be reduced to the level of physics.
Obesidad en Uruguay. Es tiempo de actuar
Authors: Rodríguez Temesio Gustavo 
Published: February 2024

Editorial sobre situación del tema Obesidad en Uruguay.
La obesidad es una enfermedad crónica, progresiva y multifactorial, en su origen participan factores genéticos, de mala adaptación metabólica, alteraciones neuroendocrinas, importantes cambios en el estilo de vida, composición de los alimentos y desigualdad social entre otros.
The prognostic and antitumor roles of key genes of ferroptosis in liver hepatocellular cancer and stomach adenocarcinoma
Authors: Pei Wenceng , Jiang Minren , Liu Haiyan , Song Jiahong , Hu Jian 
Published: February 2024

BACKGROUND: Liver hepatocellular cancer (LIHC) and stomach adenocarcinoma (STAD) are common malignancies with high lethal ratios worldwide. Great progress has been achieved by using diverse therapeutic strategies; however, these diseases still have an unfavourable prognosis. Ferroptosis inducer drugs, unlike apoptosis-related drugs, can overcome the resistance to cancer therapy caused by traditional chemicals. However, the relationship between overall survival (OS) and ferroptosis-related genes, as well as the mechanisms involved, are largely unclear. METHODS: The expression levels of AIFM2, GPX4, ACSL4, FTH1, NOS1, and PTGS2 in LIHC and STAD were obtained from UALCAN. The correlations of OS with these gene expression levels were obtained using the Kaplan-Meier Plotter database. The OS associated with genetic mutations of those genes compared to that of unchanged genes was analysed using the TIMER website. GO and KEGG enrichment analyses of ferroptosis-related genes and their coexpressed genes in LIHC and STAD were conducted using the STRING and DAVID databases. The relationship of PTGS2 and ACSL4 to immune cell infiltration was analysed using the TIMER website. The viability and GPX5 expression levels in LIHC cells treated with RSL3 and As2O3 were detected by MTT methods and western blotting, respectively. RESULTS: Our results showed that GPX4, FTH1 and AIFM2 were overexpressed in LIHC and STAD. High levels of GPX4, FTH1 and AIFM2 were prominently correlated with better prognosis in LIHC. However, GPX and FTH1 in STAD did not show significant correlations with OS. AIFM2 in STAD had the opposite trend with OS compared with that in LIHC. Moreover, a high mutation rate of these genes (35.74%) was also observed in LIHC patients, and genetic mutation of these genes was correlated with shorter OS. In contrast, the genetic mutation of these genes did not change OS in STAD. Enrichment analysis showed that the respiratory electron transport chain, cell chemotaxis and T-cell migration were related to ferroptosis. ASCL4 and PTGS2 coexpressed with cytokines associated with immune cell infiltration. Compared to RSL3 or As2O3 alone, As2O3 plus RSL3 significantly inhibited the growth of Huh7 cells. GPX4 was downregulated to an undetectable level when in combination with RSL3. CONCLUSIONS: Our results indicated that ferroptosis-related genes might play an important role in LIHC and STAD and might be risk factors for overall survival in LIHC and STAD.
Assessment of drug utilization and potentially inappropriate medications in hemodialysis patients with end-stage renal dysfunction: A study in a tertiary care hospital in Bahrain
Authors: Sridharan Kannan 
Published: February 2024

BACKGROUND: Patients undergoing dialysis pose therapeutic challenges in terms of polypharmacy, administration of potentially inappropriate drugs, and drugs with the potential risk of toxicity. OBJECTIVE: This study evaluated the use of drugs, potentially inappropriate medicines (PIM), drugs with risk of Torsades de Pointes (TdP), and the complexity of the prescribed regimen using the medication regimen complexity index scale in patients undergoing hemodialysis. METHODS: A retrospective cohort study was carried out amongst patients receiving hemodialysis. Drugs were classified into one of four classes: (i) drugs used in managing renal complications, (ii) cardiovascular drugs, (iii) anti-diabetic drugs, (iv) drugs for symptomatic management, and (v) others. Drugs were considered as PIM according to the Can-SOLVE CKD working group from a network of Canadian nephrology health professionals. The study adhered to the CredibleMeds classification of drugs with known, possible, and conditional risk of TdP and the complexity of prescribed medicines was evaluated based on the pre-validated medication regimen complexity index scale based on form/route, frequency of dosing, and requirement of special instructions. RESULTS: Sixty-three participants were included in the study (49 males and 14 females) with the median (range) age of 45 (21–66) years. Cardiovascular drugs followed by drugs used for managing renal complications were the most common classes administered. Notably, 12 (19.1%) patients received one of the non-steroidal anti-inflammatory drugs, 21 (33.3%) received a proton pump inhibitor, three (4.8%) received pregabalin, two (3.2%) received opioid drugs, and one (1.6%) was administered celecoxib. Atorvastatin, furosemide, omeprazole, and allopurinol were the most common PIM drugs administered to the study participants followed by others. Drugs used for symptomatic management had significantly more PIM compared to other classes (p < 0.0001). Six (9.5%) patients received drugs with known TdP risk, one with possible TdP risk, and 61 with conditional risk. Median (range) medical regimen complexity index score was 26.5 (2–62.5). CONCLUSION: A huge burden of drug therapy was observed in the hemodialysis patients in terms of higher proportions of PIM, complex medical regimen, and prescription of drugs with risk of TdP. Implementation of clinical decision support tools enhancing rational prescription and identification of drugs with TdP risk, introducing antimicrobial stewardship, and stepwise deprescription of the drugs with the least benefit-risk ratio are warranted.
Therapeutic evaluation of titanium dioxide nanoparticles based herbal dental varnish derived from rosemary and ginger extracts:A comprehensive investigation into anti-inflammatory and antioxidant properties
Authors: Maheshwaran Bipin , Chokkatt Jerry Joe , Shenoy Amrutha , Ganapathy Dhanraj , Yadalam Pradeep Kumar , Marrapodi Maria Maddalena , Cicciù Marco , Minervini Giuseppe 
Published: February 2024

BACKGROUND: Titanium nanoparticles (NPs) offer promising applications in the treatment and prevention of inflammatory disorders due to their unique physicochemical characteristics. However, additional research is necessary to attain a thorough comprehension and validate the efficacy of this approach in dental practice. OBJECTIVE: This study scrutinizes the anti-inflammatory properties of a dental varnish infused with ginger and rosemary extracts mediated by titanium dioxide (TiO2) nanoparticles. METHODS: A herbal dental varnish was formulated by integrating ginger and rosemary extracts with titanium dioxide nanoparticles at concentrations of 10, 20, 30, 40, and 50 μL. Anti-inflammatory properties were assessed through Bovine Serum Albumin denaturation and membrane stabilization assays, comparing results with a control group. RESULTS: The results reveal concentration-dependent antioxidant and anti-inflammatory properties in the test group when compared to the control group. The BSA assay corroborates increased percent inhibition with rising titanium dioxide nanoparticle concentrations. In line with existing literature, titanium dioxide nanoparticles enhance dental material properties. CONCLUSION: The bioactive compounds in ginger and rosemary, such as phenolic compounds and terpenes, contribute to anti-inflammatory and antioxidant effects of the varnish. Additionally, the therapeutic potential of titanium dioxide nanoparticles in addressing inflammatory diseases underscores their significance in this formulation.