bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photooxidation‐induced conformational changes and degradation behaviors of poly(butylene succinate) and poly(butylene succinate‐co‐adipate)
Authors: Padermshoke Adchara , An Yingjun , Kajiwara Tomoko , Masunaga Hiroyasu , Kobayashi Yutaka , Ito Hiroshi , Sasaki Sono , Noguchi Hiroshi , Kusuno Atsushi , Takahara Atsushi 
Published: February 2024

AbstractTwo biodegradable polyesters, poly(butylene succinate) (PBS) and poly(butylene succinate‐co‐adipate) (PBSA), were artificially aged in a UV irradiation test chamber, and their photodegradation behaviors investigated. The attenuated total reflection (ATR) infrared (IR) spectra of the initial and UV‐aged samples revealed conformational changes in the tetramethylene sequences of the photoaged PBS and PBSA. The one‐dimensional wide‐angle X‐ray scattering (WAXS) profiles showed that the (110) d‐spacing of the α‐form crystal progressively decreased during UV aging, suggesting that the crystalline polymer chains became arranged more closely along the fiber axis. Accordingly, we conclude that PBS and PBSA transform from their TGTGT to nearly TTTTT conformations upon photoaging. The observed WAXS, small‐angle X‐ray scattering, and IR spectral data suggest that photodegradation preferentially occurs in the amorphous phase of each polymer. The less crystallizable butylene adipate co‐unit enhances the degradability of PBSA, with prolonged photooxidation leading to partial degradation of the crystalline region of the copolymer. This finding is consistent with and may be linked to the higher biodegradability of PBSA compared to PBS.
Developing offshore fatigue assessment application to measure fatigue among offshore workers in Malaysia
Authors: Al‐Mekhlafi Al‐Baraa Abdulrahman , Isha Ahmad Shahrul Nizam , Hashim Ahmad Sobri 
Published: February 2024

AbstractFatigue is a significant concern in the offshore oil and gas industry, posing risks to both resources and lives. This study aims to assess fatigue levels among daily trippers on offshore platforms and compare them across different job roles. The Offshore Fatigue Assessment Application (OFAA) was developed to measure fatigue in Malaysian offshore workers, focusing on alert response and lapses. A total of 51 participants were involved, with 31 in Crew A and 20 in Crew B. Based on the results, Crew A exhibited fatigue, with only 3 out of 12 data collection points showing an average reaction time (RT) below 500 ms, mainly during post‐work periods. Crew B also experienced fatigue, with only 1 out of 12 data collection points showing an average RT below 500 ms, occurring during mid‐work. While Crew B displayed fatigue during pre‐work and mid‐work, they generally maintained alertness during their sessions. Overall, Crew A consistently faced lapses in alertness, while Crew B showed fatigue during pre‐work and mid‐work but remained alert during their sessions. These findings highlight varying fatigue levels among offshore personnel, emphasizing the need for targeted fatigue management strategies in this industry.
Energy transition technology comes with new process safety challenges and risks—What does it mean?
Authors: Pasman Hans , Sripaul Edison , Khan Faisal , Fabiano Bruno 
Published: February 2024

AbstractDecarbonization and energy transition will have a large impact on how our mobility, as well as supply of materials for clothing, building, and construction, and even for food, will be energized and processed. This review will give a brief survey of a few main changes and what they mean for process safety. It concerns hazards of hydrogen production and handling, battery systems, and electrification of the process industry, which will bring a range of changes, some easy, others intricate. Coincidentally, three recent papers in the journal Ergonomics prove to be in line with these process safety challenges.
Shrinkage priors for isotonic probability vectors and binary data modeling, with applications to dose–response modeling
Authors: Boonstra Philip S. , Owen Daniel R. , Kang Jian 
Published: February 2024

AbstractMotivated by the need to model dose–response or dose‐toxicity curves in clinical trials, we develop a new horseshoe‐based prior for Bayesian isotonic regression modeling a binary outcome against an ordered categorical predictor, where the probability of the outcome is assumed to be monotonically non‐decreasing with the predictor. The set of differences between outcome probabilities in consecutive categories of the predictor is equipped with a multivariate prior having support over simplex. The Dirichlet distribution, which can be derived from a normalized sum of independent gamma‐distributed random variables, is a natural choice of prior, but using mathematical and simulation‐based arguments, we show that the resulting posterior is prone to underflow and other numerical instabilities, even under simple data configurations. We propose an alternative prior based on horseshoe‐type shrinkage that is numerically more stable. We show that this horseshoe‐based prior is not subject to the numerical instability seen in the Dirichlet/gamma‐based prior and that the horseshoe‐based posterior can estimate the underlying true curve more efficiently than the Dirichlet‐based one. We demonstrate the use of this prior in a model predicting the occurrence of radiation‐induced lung toxicity in lung cancer patients as a function of dose delivered to normal lung tissue. Our methodology is implemented in the R package isotonicBayes and therefore suitable for use in the design of dose‐finding studies or other dose–response modeling contexts.
Therapeutic effects and molecular mechanisms of natural products in thrombosis
Authors: Yuan Ming‐hao , Zhong Wen‐xiao , Wang Yu‐lu , Liu Yu‐shi , Song Jia‐wen , Guo Yu‐rou , Zeng Bin , Guo Yi‐ping , Guo Li 
Published: February 2024

AbstractThrombotic disorders, such as myocardial infarction and stroke, are the leading cause of death in the global population and have become a health problem worldwide. Drug therapy is one of the main antithrombotic strategies, but antithrombotic drugs are not completely safe, especially the risk of bleeding at therapeutic doses. Recently, natural products have received widespread interest due to their significant efficacy and high safety, and an increasing number of studies have demonstrated their antithrombotic activity. In this review, articles from databases, such as Web of Science, PubMed, and China National Knowledge Infrastructure, were filtered and the relevant information was extracted according to predefined criteria. As a result, more than 100 natural products with significant antithrombotic activity were identified, including flavonoids, phenylpropanoids, quinones, terpenoids, steroids, and alkaloids. These compounds exert antithrombotic effects by inhibiting platelet activation, suppressing the coagulation cascade, and promoting fibrinolysis. In addition, several natural products also inhibit thrombosis by regulating miRNA expression, anti‐inflammatory, and other pathways. This review systematically summarizes the natural products with antithrombotic activity, including their therapeutic effects, mechanisms, and clinical applications, aiming to provide a reference for the development of new antithrombotic drugs.
The ameliorative effect of turmeric (Curcuma longa Linn) extract and its major constituent, curcumin, and its analogs on ethanol toxicity
Authors: Ghasemzadeh Rahbardar Mahboobeh , Hosseinzadeh Hossein 
Published: February 2024

AbstractEthanol toxicity is a major public health problem that can cause damage to various organs in the body by several mechanisms inducing oxidative stress, inflammation, and apoptosis. Recently, there has been a growing interest in the potential of herbal medicines as therapeutic agents for the prevention and treatment of various disorders. Turmeric (Curcuma longa) extracts and its main components including curcumin have antioxidant, anti‐inflammatory, and anti‐apoptotic properties. This review aims to evaluate the literature on the ameliorative effects of turmeric extracts and their main components on ethanol toxicity. The relevant studies were identified through searches of Google Scholar, PubMed, and Scopus without any time limitation. The underlying mechanisms of turmeric and curcumin were also discussed. The findings suggest that turmeric and curcumin ameliorate ethanol‐induced organ damage by suppressing oxidative stress, inflammation, apoptosis, MAPK activation, TGF‐β/Smad signaling pathway, hyperlipidemia, regulating hepatic enzymes, expression of SREBP‐1c and PPAR‐α. However, the limited clinical evidence suggests that further research is needed to determine the efficacy and safety of turmeric and curcumin in human subjects. In conclusion, the available evidence supports the potential use of turmeric and curcumin as alternative treatments for ethanol toxicity, but further high‐quality studies are needed to firmly establish the clinical efficacy of the plant.
Enhanced mechanical, optoelectronic and thermoelectric properties of binary CdO by under pressure: An ab initio study
Authors: Erum Nazia , Sharma Ramesh , Anwar Nadia , Al‐Qaisi Samah , Al‐Anazy Murefah mana , Yousef El Sayed 
Published: February 2024

AbstractThis manuscript presents, under the effect of different pressures (0–60 GPa), the structural, mechanical, electronic, optical, and thermoelectric properties of CdO with NaCl type structure by using the FP‐LAPW (Full Potential Linearized Augmented Plane Wave method) with Generalized Gradient Approximation (GGA) whose basis is the Density Functional Theory (DFT). PBE‐GGA was used to compute the structural, elastic, optical, electronic, and thermoelectric properties using Tran‐Blaha modified Becke‐Johnson (TB‐mBJ) potential. Different terms like formation energy, cohesive energy, and phonon were used for the computation of thermal stability and that is further confirmed by elastic properties. Bulk moduli and pressure‐dependent lattice constants were achieved by using the optimization method. From the results, we can say that the increase in pressure is directly related to the band gap and inversely related to the lattice constant. The mechanical properties show that CdO is highly ductile and mechanically stable and ductility is directly related to pressure. The minimum conduction band goes to a higher energy level when the pressure increases while the maximum valance band goes to a lower energy level ultimately the energy band gap increases. The optical parameter curve does not change by increasing pressure but the peaks start moving towards the higher energies slightly. Calculations reveals that band gap increases by increasing pressure which shows the blue shift in optical properties. The optical properties spectrum was studied, including reflectance, dielectric coefficient, and absorption coefficient. The optical constants show that the phase of CdO with NaCl structure was translucent. In the end, the thermoelectric feature in terms of thermal conductivity (K), power factor (PF), Seebeck coefficient (S), and electrical conductivity (σ) were studied by using the BoltzTrap code as a function of temperature. Thermoelectric and optical aspects revealed that pressure induces the possible use of CdO material for various TE and optical applications.
Exploring the effect of R&D support, green technology transfer, sustainable innovation
Authors: Adomako Samuel , Tran Mai Dong 
Published: February 2024

AbstractThis article investigates the impact of R&D support on sustainable innovation through the mediating role of green technology transfer. Based on our analysis of data from 220 firms in Vietnam, we find the following: (1) R&D support has a positive impact on green technology transfer, (2) green technology transfer mediates the relationship between R&D support and sustainable innovation, and (3) The influence of green technology transfer on sustainable innovation is heightened in the presence of a firm's commitment to environmental ethics. These findings underline the critical role of government R&D funding in shaping sustainable innovation in emerging markets. The findings further show the crucial role of environmental commitment as a moderating factor in green technology transfer contexts. Managing the interaction between green technology transfer and a firm's commitment to environmental ethics is essential to optimize the benefits of sustainable innovation. This study offers practical insights for firms seeking to improve their sustainable innovation outcomes.
Sustainable biogas production potential in Nepal using waste biomass: A spatial analysis
Authors: Lohani Sunil Prasad , Acharya Renisha , Shrestha Poushan , Shrestha Sundar , Manisha K. C. , Pradhan Prajal 
Published: February 2024

AbstractBiogas plays a significant part in replacing solid biomass and fossil fuels for cooking. However, the implementation of appropriate policies to promote the development of biogas plants is hindered by a lack of adequate assessment of the biogas potential in Nepal. Thus, we estimate the potential of biogas production at the district level of Nepal from available waste biomass, including livestock manure, agricultural residues, and organic fraction of municipal solid waste (OFMSW). Our estimates show the theoretical potential of biogas production from livestock manure of 1890 million m3 year−1, agricultural residues of 2290 million m3 year−1, and OFMSW of 234 million m3 year−1. The total biogas production is 4412 million m3 year−1, equivalent to 153 million liquefied petroleum gas (LPG) cylinders yearly. Using this biogas potential to replace LPG and solid biomass for cooking could result in avoided CO2, CO, and PM2.5 emissions of 6.3 million tons year−1, 0.4 million tons year−1, and 0.04 million tons year−1, respectively. Our findings suggest that the Terai districts of Morang, Sunsari, Saptari, and Banke, as well as the Hilly districts of Kavrepalanchok, Dhading, and Nuwakot, have a significant amount of biogas‐producing potential. Utilising this potential could also contribute to achieving several Sustainable Development Goals and a clean cooking energy transition in Nepal. For this, governments need careful planning, designing, policy support, and facilitation on bio‐resource management and utilisation at the local level.
Recent Progress in Photocatalytic Reduction of CO2 by ZnIn2S4‐based Heterostructures
Authors: Li Mingming , Chen Shaohua , Wang Yihua , Zhang Jinhua 
Published: February 2024

AbstractAs a green technology, photocatalytic reduction of CO2 can reduce CO2 into reusable carbon‐based fuels and alleviate environmental and energy problems to a certain extent. However, traditional photocatalytic materials have irreparable defects that limit their applications in photocatalysis, and it becomes a great challenge to find an efficient photocatalytic material. ZnIn2S4, a new photocatalyst, is widely used in photocatalysis because of its layered structure, tunable band gap, excellent photoelectric properties, and catalytic characteristics, and it is also favored by a wide range of scientific researchers due to its stable chemical properties. The construction of heterojunctions can further increase the photocatalytic ability of ZnIn2S4. This review introduces the electron transfer mechanism of different ZnIn2S4‐based heterojunctions in the photocatalytic process and its recent research progress in photocatalytic CO2 reduction applications. Finally, an outlook on constructing ZnIn2S4‐based heterojunctions and their development prospects is presented.
pH/H2O2 Cascade‐Responsive Nanoparticles of Lipid‐Like Prodrugs through Dynamic‐Covalent and Coordination Interactions for Chemotherapy
Authors: Xiao Wanyue , Geng Rui , Bi Duohang , Luo Yi , Zhang Zihan , Gan Quan , Liu Yijing , Zhu Jintao 
Published: February 2024

AbstractTraditional lipid nanoparticles (LNPs) suffer from low drug loading capacity (DLC), weak stability, and lack of responsiveness. Conventional approaches to address these issues involve the synthesis of lipid‐prodrug by incorporating responsive covalent linkers. However, such approaches often result in suboptimal sensitivity for drug release and undermine therapeutic effectiveness. Herein, the study reports a fundamentally different concept for designing lipid‐like prodrugs through boron–nitrogen (B‐N) coordination and dynamic covalent interaction. The 5‐fluorouracil‐based lipid‐like prodrugs, featuring a borate ester consisting of a glycerophosphoryl choline head and a boronic acid‐modified 5Fu/dodecanamine complex tail, are used to prepare pH/H2O2 cascade‐responsive LNPs (5Fu‐LNPs). The 5Fu‐LNPs exhibit enhanced DLC and stability in a neutral physiological environment due to the B‐N coordination and enhanced hydrophobicity. In tumors, acidic pH triggers the dissociation of B‐N coordination to release prodrugs, which further responds to low H2O2 concentrations to release drugs, showcasing a potent pH/H2O2‐cascade‐responsive property. Importantly, 5Fu‐LNPs demonstrate greater antitumor efficiency and lower toxicity compared to the commercial 5Fu. These results highlight 5Fu‐LNPs as a safer and more effective alternative to chemotherapy. This work presents a unique LNP fabrication strategy that can overcome the limitations of conventional LNPs and broaden the range of intelligent nanomaterial preparation techniques.
TiN as Radical Scavenger in Fe─N─C Aerogel Oxygen Reduction Catalyst for Durable Fuel Cell
Authors: Luo Yi , Li Ke , Hu Yijie , Chen Teng , Wang Qichen , Hu Jianqiang , Feng Jian , Feng Junzong 
Published: February 2024

AbstractFe─N─C is the most promising alternative to platinum‐based catalysts to lower the cost of proton‐exchange‐membrane fuel cell (PEMFC). However, the deficient durability of Fe─N─C has hindered their application. Herein, a TiN‐doped Fe─N─C (Fe─N─C/TiN) is elaborately synthesized via the sol–gel method for the oxygen‐reduction reaction (ORR) in PEMFC. The interpenetrating network composed by Fe─N─C and TiN can simultaneously eliminate the free radical intermediates while maintaining the high ORR activity. As a result, the H2O2 yields of Fe─N─C/TiN are suppressed below 4%, ≈4 times lower than the Fe─N─C, and the half‐wave potential only lost 15 mV after 30 kilo‐cycle accelerated durability test (ADT). In a H2─O2 fuel cell assembled with Fe─N─C/TiN, it presents 980 mA cm−2 current density at 0.6 V, 880 mW cm−2 peak power density, and only 17 mV voltage loss at 0.80 A cm−2 after 10 kilo‐cycle ADT. The experiment and calculation results prove that the TiN has a strong adsorption interaction for the free radical intermediates (such as *OH, *OOH, etc.), and the radicals are scavenged subsequently. The rational integration of Fe single‐atom, TiN radical scavenger, and highly porous network adequately utilize the intrinsic advantages of composite structure, enabling a durable and active Pt‐metal‐free catalyst for PEMFC.
Si/CuO Heterojunction‐Based Photomemristor for Reconfigurable, Non‐Volatile, and Self‐Powered In‐Sensor Computing
Authors: Leng Kangmin , Wan Yu , Fu Yao , Wang Li , Wang Qisheng 
Published: February 2024

AbstractIn‐sensor computing has attracted considerable interest as a solution for overcoming the energy efficiency and response time limitations of the traditional von Neumann architecture. Recently, emerging memristors based on transition‐metal oxides (TMOs) have attracted attention as promising candidates for in‐memory computing owing to their tunable conductance, high speed, and low operational energy. However, the poor photoresponse of TMOs presents challenges for integrating sensing and processing units into a single device. This integration is crucial for eliminating the need for a sensor/processor interface and achieving energy‐efficient in‐sensor computing systems. In this study, a Si/CuO heterojunction‐based photomemristor is proposed that combines the reversible resistive switching behavior of CuO with the appropriate optical absorption bandgap of the Si substrate. The proposed photomemristor demonstrates a simultaneous reconfigurable, non‐volatile, and self‐powered photoresponse, producing a microampere‐level photocurrent at zero bias. The controlled migration of oxygen vacancies in CuO result in distinct energy‐band bending at the interface, enabling multiple levels of photoresponsivity. Additionally, the device exhibits high stability and ultrafast response speed to the built‐in electric field. Furthermore, the prototype photomemristor can be trained to emulate the attention‐driven nature of the human visual system, indicating the tremendous potential of TMO‐based photomemristors as hardware foundations for in‐sensor computing.
Transepithelial Electrical Impedance Increase Following Porous Substrate Electroporation Enables Label‐Free Delivery
Authors: Brooks Justin R. , Heiman Tyler C. , Lorenzen Sawyer R. , Mungloo Ikhlaas , Mirfendereski Siamak , Park Jae Sung , Yang Ruiguo 
Published: February 2024

AbstractPorous substrate electroporation (PSEP) is a promising new method for intracellular delivery, yet fundamentals of PSEP are not well understood, especially the intermediate processes leading to delivery. PSEP is an electrical method, yet the relationship between PSEP and electrical impedance remains underexplored. In this study, a device capable of measuring impedance and performing PSEP is developed and the changes in transepithelial electrical impedance (TEEI) are monitored. These measurements show TEEI increases following PSEP, unlike other electroporation methods. The authors then demonstrate how cell culture conditions and electrical waveforms influence this response. More importantly, TEEI response features are correlated with viability and delivery efficiency, allowing prediction of outcomes without fluorescent cargo, imaging, or image processing. This label‐free delivery also allows improved temporal resolution of transient processes following PSEP, which the authors expect will aid PSEP optimization for new cell types and cargos.
Self‐Implantable Core–Shell Microneedle Patch for Long‐Acting Treatment of Keratitis via Programmed Drug Release
Authors: Jiang Xue , Jin Yinli , Zeng Yongnian , Shi Peng , Li Wei 
Published: February 2024

AbstractBacteria‐induced keratitis is a major cause of corneal blindness in both developed and developing countries. Instillation of antibiotic eyedrops is the most common management of bacterial keratitis but usually suffers from low bioavailability (i.e., <5%) and frequent administration, due to the existence of corneal epithelial barrier that prevents large and hydrophilic drug molecules from entering the cornea, and the tear film on corneal surface that rapidly washes drug away from the cornea. Here, a self‐implantable core–shell microneedle (MN) patch with programmed drug release property to facilitate bacterial keratitis treatment is reported. The pH‐responsive antimicrobial nanoparticles (NPs), Ag@ZIF‐8, which are capable of producing antibacterial metal ions in the infected cornea and generating oxidative stress in bacteria, are loaded in the dissolvable core, while the anti‐angiogenic drug, rapamycin (Rapa), is encapsulated in the biodegradable shell, thereby enabling rapid release of Ag@ZIF‐8 NPs and sustained release of Rapa after corneal insertion. Owing to the programmed release feature, one single administration of the core–shell MN patch in a rat model of bacterial keratitis, can achieve satisfactory antimicrobial activity and superior anti‐angiogenic and anti‐inflammation effects as compared to daily topical eyedrops, indicating a great potential for the infectious keratitis therapy in clinics.