bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammatory Pseudotumor of the Maxillary Sinus: Case Reports and Review of the Literature
Authors: Reino Anthony J. , Lawson William , Som Peter 
Published: September 2007

The term inflammatory pseudotumor (IPT) has been applied to a benign, reactive, non-neoplastic and inflammatory space occupying lesion that clinically and radiographically mimics a neoplasm. Histologically, IPT is composed of polymorphous inflammatory cell infiltrates and variable fibrous stroma containing thick walled blood vessels. Aggressive pseudotumors must be distinguished from malignancy to avoid unnecessary surgery or irradiation. Some cases can be differentiated from neoplasms by their dramatic response to oral steroid therapy. Because of the diverse cellular proliferation, diagnosis can be difficult, especially on frozen section study. Primary pseudotumor of the maxillary sinus is an extremely rare entity. An extensive review of the literature has produced only four reported cases. We describe six cases of pseudotumor of the maxillary sinus that had clinical and radiographic findings suggesting neoplasia. The purpose of this paper is to report these new cases of maxillary sinus pseudotumor and to better define its natural history, criteria for diagnosis, and selection of treatment.
Exclusive Breastfeeding Duration and Risk of Childhood Cancers
Authors: Søegaard Signe Holst , Andersen Mie Mølgaard , Rostgaard Klaus , Davidsson Olafur Birgir , Olsen Sjurdur Frodi , Schmiegelow Kjeld , Hjalgrim Henrik 
Published: March 2024

ImportanceBreastfeeding has been suggested to protect against childhood cancers, particularly acute lymphoblastic leukemia (ALL). However, the evidence stems from case-control studies alone.ObjectiveTo investigate whether longer duration of exclusive breastfeeding is associated with decreased risk of childhood ALL and other childhood cancers.Design, Setting, and ParticipantsThis population-based cohort study used administrative data on exclusive breastfeeding duration from the Danish National Child Health Register. All children born in Denmark between January 2005 and December 2018 with available information on duration of exclusive breastfeeding were included. Children were followed up from age 1 year until childhood cancer diagnosis, loss to follow-up or emigration, death, age 15 years, or December 31, 2020. Data were analyzed from March to October 2023.ExposureDuration of exclusive breastfeeding in infancy.Main Outcomes and MeasuresAssociations between duration of exclusive breastfeeding and risk of childhood cancer overall and by subtypes were estimated as adjusted hazard ratios (AHRs) with 95% CIs using stratified Cox proportional hazards regression models.ResultsA total of 309 473 children were included (51.3% boys). During 1 679 635 person-years of follow-up, 332 children (0.1%) were diagnosed with cancer at ages 1 to 14 years (mean [SD] age at diagnosis, 4.24 [2.67] years; 194 boys [58.4%]). Of these, 124 (37.3%) were diagnosed with hematologic cancers (81 [65.3%] were ALL, 74 [91.4%] of which were B-cell precursor [BCP] ALL), 44 (13.3%) with central nervous system tumors, 80 (24.1%) with solid tumors, and 84 (25.3%) with other and unspecified malignant neoplasms. Compared with exclusive breastfeeding duration of less than 3 months, exclusive breastfeeding for 3 months or longer was associated with a decreased risk of hematologic cancers (AHR, 0.66; 95% CI, 0.46-0.95), which was largely attributable to decreased risk of BCP-ALL (AHR, 0.62; 95% CI, 0.39-0.99), but not with risk of central nervous system tumors (AHR, 0.96; 95% CI, 0.51-1.88) or solid tumors (AHR, 0.87; 95% CI, 0.55-1.41).Conclusions and RelevanceIn this cohort study, longer duration of exclusive breastfeeding was associated with reduced risk of childhood BCP-ALL, corroborating results of previous case-control investigations in this field. To inform future preemptive interventions, continued research should focus on the potential biologic mechanisms underlying the observed association.
Lattice Oxygen Redox Mechanisms in the Alkaline Oxygen Evolution Reaction
Authors: Ren Xiangrong , Zhai Yiyue , Yang Na , Wang Bolun , Liu Shengzhong (Frank) 
Published: March 2024

AbstractUnderstanding of fundamental mechanism and kinetics of the oxygen evolution reaction (OER) is pivotal for designing efficient OER electrocatalysts owing to its key role in electrochemical energy conversion devices. In the past few years, the lattice oxygen oxidation mechanism (LOM) arising from the anodic redox chemistry has attracted significant attention as it involves a direct O─O coupling and thus bypasses thermodynamic limitations in the traditional adsorbate evolution mechanism (AEM). Transition metal‐based oxyhydroxides are generally acknowledged as the real catalytic phase in alkaline media. In particular, their low‐dimensional layered structures offer sufficient structural flexibility to trigger the LOM. Herein, a comprehensive overview is provided for recent advances in anion redox from LOM‐based electrocatalysts. Based on analyses of electronic structure of electrocatalysts and LOM, a strategy is proposed to activate LOM. Possible identification techniques for corroboration of the oxygen redox are also reviewed. In addition, the structural reconstruction process induced by the LOM is focused and the importance of multiple in situ/operando characterizations is highlighted to unveil the structural and chemical origins of the LOM. To conclude, a prospect on the remaining challenges and future opportunities for LOM electrocatalysts is presented.
Mitochondrial‐Targeted Copper Delivery for Cuproptosis‐Based Synergistic Cancer Therapy
Authors: Deng Jinpeng , Zhuang Huilan , Shao Sijie , Zeng Xuemei , Xue Panpan , Bai Tingjie , Wang Xiaoman , Shangguan Shijie , Chen Yuanchun , Yan Shuangqian , Huang Wei 
Published: March 2024

AbstractCuproptosis is dependent on mitochondrial respiration modulation by targeting lipoylated tricarboxylic acid cycle (TCA) cycle proteins, showing great potential in cancer treatment. However, the specific release of copper ions at mitochondrial is highly needed and still a major challenge to trigger cellular cuproptosis. Herein, a metal‐organic framework‐based nanoplatform (ZCProP) is designed for mitochondrial‐targeted and ATP/pH‐responsive Cu2+ and prodigiosin release. The released Cu2+ promotes aggregation of lipoylated protein and loss of Fe‐S cluster protein, resulting in cell cuproptosis. In the meanwhile, Cu2+ can concert with prodigiosin to induce mitochondrial dysfunction and DNA damage and enhance cell cuproptosis. Furthermore, this nanoplatform has an ability to deplete glutathione, which not only further promotes cuproptosis but also triggers cell ferroptosis by the suppression of glutathione peroxidase 4, an anti‐ferroptosis protein. Collectively, the designed ZCProP nanoplatform can responsively release cargos at mitochondrial and realize a conspicuous therapeutic efficacy through a cuproptosis‐mediated concerted effect. Along with its excellent biocompatibility, this nanoplatform may provide a novel therapeutic modality paradigm to boost cancer therapeutic strategies based on cuproptosis.
Record‐Efficiency Printable Hole‐Conductor‐Free Mesoscopic Perovskite Solar Cells Enabled by the Multifunctional Schiff Base Derivative
Authors: Chen Kai , Xiao Xufeng , Liu Jiale , Qi Jianhang , Gao Qiaojiao , Ma Yongming , Cheng Yanjie , Mei Anyi , Han Hongwei 
Published: March 2024

AbstractTailoring multifunctional additives for performing interfacial modifications, improving crystallization, and passivating defects is instrumental for the fabrication of efficient and stable perovskite solar cells (PSCs). Here, a Schiff base derivative, (chloromethylene) dimethyliminium chloride (CDCl), is introduced as an additive to modify the interface between the mesoporous TiO2 electron transport layer and the MAPbI3 light absorber during the annealing process. CDCl chemically links to TiO2 and MAPbI3 through coordination and hydrogen bonding, respectively, and results in the construction of fast electron extraction channels. CDCl also optimizes the energy‐level alignment of the TiO2/MAPbI3 heterojunction and improves the pore‐filling and crystallization of MAPbI3 in the mesoscopic scaffold, which inhibits nonradiative recombination and eliminates open‐circuit voltage losses. As a result, an impressive power conversion efficiency of 19.74%, which is the best one ever reported, is obtained for printable carbon‐based hole‐conductor‐free PSCs based on MAPbI3.
Rapid Phenotypic Antibiotics Susceptibility Analysis by a 3D Printed Prototype
Authors: Riester Oliver , Kaiser Lars , Laufer Stefan , Deigner Hans‐Peter 
Published: March 2024

AbstractOne of the most important public health concerns is the increase in antibiotic‐resistant pathogens and corresponding treatment of associated infections. Addressing this challenge requires more efficient use of antibiotics, achievable by the use of evidence‐based, effective antibiotics identified by antibiotic susceptibility testing (AST). However, the current standard method of phenotypic AST used for this purpose requires 48 h or more from sample collection to result. Until results are available, broad‐spectrum antibiotics are used to avoid delaying treatment. The turnaround time must therefore be shortened in order for the results to be available before the second administration of antibiotics. The phenotypic electrochemical AST method presented here identifies effective antibiotics within 5–10 h after sampling. Spiked serum samples, including polymicrobial samples, with clinically relevant pathogens and respective concentrations commonly found in bloodstream infections (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa) are used. Direct loading of the test with diluted serum eliminates the need for a pre‐culture, as required by existing methods. Furthermore, by combining several electrochemical measurement procedures with computational analysis, allowing the method to be used both online and offline, the AST achieves a sensitivity of 94.44% and a specificity of 95.83% considering each replicate individually.
All‐Trans‐Retinoic Acid‐Adjuvanted mRNA Vaccine Induces Mucosal Anti‐Tumor Immune Responses for Treating Colorectal Cancer
Authors: Li Wei , Li Yijia , Li Jingjiao , Meng Junli , Jiang Ziqiong , Yang Chen , Wen Yixing , Liu Shuai , Cheng Xingdi , Mi Shiwei , zhao Yuanyuan , Miao Lei , Lu Xueguang 
Published: March 2024

AbstractMessenger RNA (mRNA) cancer vaccines are a new class of immunotherapies that can activate the immune system to recognize and destroy cancer cells. However, their effectiveness in treating colorectal cancer located on the mucosal surface of the gut is limited due to the insufficient activation of mucosal immune response and inadequate infiltration of cytotoxic T cells into tumors. To address this issue, a new mRNA cancer vaccine is developed that can stimulate mucosal immune responses in the gut by co‐delivering all‐trans‐retinoic acid (ATRA) and mRNA using lipid nanoparticle (LNP). The incorporation of ATRA has not only improved the mRNA transfection efficiency of LNP but also induced high expression of gut‐homing receptors on vaccine‐activated T cells. Additionally, the use of LNP improves the aqueous solubility of ATRA, eliminating the need for toxic solvents to administer ATRA. Upon intramuscular injections, ATRA‐adjuvanted mRNA‐LNP significantly increase the infiltration of antigen‐specific, cytotoxic T cells in the lamina propria of the intestine, mesenteric lymph nodes, and orthotopic colorectal tumors, resulting in significantly improved tumor inhibition and prolonged animal survival compared to conventional mRNA‐LNP without ATRA. Overall, this study provides a promising approach for improving the therapeutic efficacy of mRNA cancer vaccines against colorectal cancer.
Crossbreeding Effect of Chalcogenation and Iodination on Benzene Additives Enables Optimized Morphology and 19.68% Efficiency of Organic Solar Cells
Authors: Zhou Tao , Jin Wenwen , Li Yinfeng , Xu Xiaopeng , Duan Yuwei , Li Ruipeng , Yu Liyang , Peng Qiang 
Published: March 2024

AbstractVolatile solid additives have attracted increasing attention in optimizing the morphology and improving the performance of currently dominated non‐fullerene acceptor‐based organic solar cells (OSCs). However, the underlying principles governing the rational design of volatile solid additives remain elusive. Herein, a series of efficient volatile solid additives are successfully developed by the crossbreeding effect of chalcogenation and iodination for optimizing the morphology and improving the photovoltaic performances of OSCs. Five benzene derivatives of 1,4‐dimethoxybenzene (DOB), 1‐iodo‐4‐methoxybenzene (OIB), 1‐iodo‐4‐methylthiobenzene (SIB), 1,4‐dimethylthiobenzene (DSB) and 1,4‐diiodobenzene (DIB) are systematically studied, where the widely used DIB is used as the reference. The effect of chalcogenation and iodination on the overall property is comprehensively investigated, which indicates that the versatile functional groups provided various types of noncovalent interactions with the host materials for modulating the morphology. Among them, SIB with the combination of sulphuration and iodination enabled more appropriate interactions with the host blend, giving rise to a highly ordered molecular packing and more favorable morphology. As a result, the binary OSCs based on PM6:L8‐BO and PBTz‐F:L8‐BO as well as the ternary OSCs based on PBTz‐F:PM6:L8‐BO achieved impressive high PCEs of 18.87%, 18.81% and 19.68%, respectively, which are among the highest values for OSCs.
A Single‐Step Cleaning Process for Simultaneous Removal of Surface Impurities and Passivation of Sub‐Surface Defects in Perovskite Solar Cells
Authors: Cai Wanxian , Wang Yudi , Li Wenzhe , Yin Yanfeng , Liu Jing , Cai Wanqing , Wang Shuhong , Guo Jingya , Chang Shuai , Li Shukui , Wang Xiuyun , Shi Yantao 
Published: March 2024

AbstractPerovskite solar cells (PSCs) suffer from the presence of non‐active and metastable species on the surface of solution‐processed perovskite films, and their adverse effects on charge extraction and long‐term stability cannot be fully addressed by conventional surface passivation strategies. In this study, a novel concept is proposed to achieve both precise removal of surface impurities and effective passivation of sub‐surface defects in a single step, utilizing a functional polymer‐based cleaning strategy. The moderate intermolecular force provided by the functional polymer and their inherent robust interchain interactions enable effective surface cleaning without disturbing the active crystal lattice. Following surface cleaning, the electron‐donating groups (C═O) in the polymer passivate the uncoordinated Pb2+ defects at the sub‐surface level. This synergistic effect of surface cleaning and sub‐surface defect passivation leads to a drastic reduction in interfacial non‐radiative recombination, elimination of ion migration pathways, and prevention of triggers for photodegradation. As a result, the power conversion efficiency (PCE) significantly improved from 22.84% to 25.51%, accompanied by a remarkable enhancement in operational stability. Moreover, the operability and effectiveness of this approach make it highly suitable for scaling up perovskite solar modules in the future.
Capuchin monkeys' (Sapajus [Cebus] apella) categorization of photos of unknown male conspecifics suggests attention to fWHR and a dominance bias
Authors: Meacham Ashley M. , Sosnowski Meghan J. , Kleider‐Offutt Heather M. , Brosnan Sarah F. 
Published: March 2024

AbstractThe ability to quickly perceive others' rank minimizes costs by helping individuals behave appropriately when interacting with strangers. Indeed, humans and at least some other species can quickly determine strangers' rank or dominance based only on physical features without observing others' interactions or behavior. Nonhuman primates can determine strangers' ranks by observing their interactions, and some evidence suggests that at least some cues to dominance, such as facial width‐to‐height ratio (fWHR), are also present in other primates. However, it is unknown whether they can determine strangers' rank simply by looking at their faces, rather than observing their interactions. If so, this would suggest selective pressure across the primates on both cues to dominance and the ability to detect those cues accurately. To address this, we examined the ability of male and female tufted capuchin monkeys (Sapajus [Cebus] apella) to categorize images of the faces of unknown conspecifics (Sapajus from different colonies) and humans (computer‐generated and real) as dominant or nondominant based only on still images. Capuchins' categorization of unknown conspecific faces was consistent with fWHR, a cue to dominance, although there was a strong tendency to categorize strangers as dominant, particularly for males. This was true despite the continued correct categorization of known individuals. In addition, capuchins did not categorize human strangers in accordance with external pre‐ratings of dominance by independent human raters, despite the availability of the same cue, fWHR. We consider these results in the context of capuchin socio‐ecology and what they mean for the evolution of rapid decision‐making in social contexts.
Real‐World Healthcare Cost Savings and Reduced Relapse Rate with Off‐Label Rituximab versus Disease‐Modifying Treatments Approved for Relapsing–Remitting Multiple Sclerosis: A Nationwide Cost‐Effectiveness Study
Authors: Alping Peter , Neovius Martin , Piehl Fredrik , Frisell Thomas 
Published: March 2024

ObjectiveAlthough off‐label use of rituximab is a common alternative to disease‐modifying therapies (DMTs) approved for multiple sclerosis (MS) in several countries, the impact of this on treatment cost‐effectiveness is not well known.MethodsWe evaluated the relative cost‐effectiveness of rituximab and MS‐approved DMTs in a register‐based cohort study of Swedish residents with relapsing–remitting MS, aged 18–65 years, starting treatment with rituximab, natalizumab, fingolimod, or dimethyl fumarate between January 2010 and July 2016, and followed through July 2021 (n = 5,924). By linking the population‐based Swedish MS register to several Swedish health care and demographic registers, we estimated health care costs in relation to number of relapses, over 5 years from treatment start. Differences between treatments were estimated in inverse probability of treatment‐weighted regression models, adjusting for a broad range of potential confounders covering demographics, medical history, and MS‐related clinical characteristics.ResultsOff‐label rituximab was associated with both lower total health care costs (mean cost savings ranged $35,000–$66,000 vs. each approved DMT), and fewer relapses (mean number of prevented relapses ranged 0.12–0.22), per started therapy over 5 years. Results were robust to variations in discounting and pricing of health care visits, with the main driver of cost‐savings being the price of the index drug itself.InterpretationThe cost‐effectiveness of rituximab dominated the MS‐approved alternatives. Off‐label, low‐dose rituximab should be considered for persons with MS and could reduce barriers to treatment, especially in resource‐limited settings. ANN NEUROL 2024;95:1099–1111
Superoxide Radicals in Uranyl Peroxide Solids: Lasting Signatures Identified by Electron Paramagnetic Resonance Spectroscopy
Authors: Scherrer Sarah K. , Gates Cassandra , Rajapaksha Harindu , Greer Samuel M. , Stein Benjamin W. , Forbes Tori Z. 
Published: March 2024

AbstractU(VI) peroxide phases (studtite and meta‐studtite) are found throughout the nuclear fuel cycle and exist as corrosion products in high radiation fields. Peroxides are part of a family of reactive oxygen species (ROS) that include hydroperoxyl and superoxide species and are produced during alpha radiolysis of water. While U(VI) peroxides have been thoroughly investigated, the incorporation and stability of ROS species within studtite have not been validated. In the current study, electron paramagnetic resonance (EPR) spectroscopy was used to identify the presence of free radicals within a series of U(VI) peroxide samples containing depleted, highly enriched, and natural uranium. Density functional theory calculations indicated that the predicted EPR signals matched well with a superoxide (O2−⋅) species incorporated into the studtite structure, confirming the presence of ROS in the material. Further analysis of samples that were synthesized between 1945 and 2023 indicated that there is a correlation between the radical signal and the product of specific activity multiplied by age of the sample.
Protein‐Integrated Hydrogen‐Bonded Organic Frameworks: Chemistry and Biomedical Applications
Authors: Li Lijuan , Ma Tianyu , Wang Ming 
Published: March 2024

AbstractHydrogen‐bonded organic frameworks (HOFs) are porous nanomaterials that offer exceptional biocompatibility and versatility for integrating proteins for biomedical applications. This minireview concisely discusses recent advancements in the chemistry and functionality of protein‐HOF interfaces. It particularly focuses on strategic methodologies, such as the careful selection of building blocks and the genetic engineering of proteins, to facilitate protein‐HOF interactions. We examine the role of enzyme encapsulation within HOFs, highlighting its capability to preserve enzyme function, a crucial aspect for applications in biosensing and disease diagnosis. Moreover, we discuss the emerging utility of nanoscale HOFs for intracellular protein delivery, illustrating their applicability as nanoreactors for intracellular catalysis and neuroprotective biorthogonal catalysis within cellular compartments. We highlight the significant advancement of designing biodegradable HOFs tailored for cytosolic protein delivery, underscoring their promising application in targeted cancer therapies. Finally, we provide a perspective viewpoint on the design of biocompatible protein‐HOF assemblies, underlining their promising prospects in drug delivery, disease diagnosis, and broader biomedical applications.
Bioinspired Synthesis of Allysine for Late‐Stage Functionalization of Peptides
Authors: Emenike Benjamin , Shahin Sophia , Raj Monika 
Published: March 2024

AbstractInspired by the enzyme lysyl oxidase, which selectively converts the side chain of lysine into allysine, an aldehyde‐containing post‐translational modification, we report herein the first chemical method for the synthesis of allysine by selective oxidation of dimethyl lysine. This approach is highly chemoselective for dimethyl lysine on proteins. We highlight the utility of this biomimetic approach for generating aldehydes in a variety of pharmaceutically active linear and cyclic peptides at a late stage for their diversification with various affinity and fluorescent tags. Notably, we utilized this approach for generating small‐molecule aldehydes from the corresponding tertiary amines. We further demonstrated the potential of this approach in generating cellular models for studying allysine‐associated diseases.