bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Imitation Switch Protein SNF2L Regulates Steroidogenic Acute Regulatory Protein Expression during Terminal Differentiation of Ovarian Granulosa Cells
Authors: Lazzaro Maribeth A. , Pépin David , Pescador Nazario , Murphy Bruce D. , Vanderhyden Barbara C. , Picketts David J. 
Published: June 2006

Abstract
Luteinization is a complex process, stimulated by gonadotropins, that promotes ovulation and development of the corpus luteum through terminal differentiation of granulosa cells. The pronounced expression of the mammalian imitation switch (ISWI) genes, SNF2H and SNF2L, in adult ovaries prompted us to investigate the role of these chromatin remodeling proteins during follicular development and luteinization. SNF2H expression is highest during growth of preovulatory follicles and becomes less prevalent during luteinization. In contrast, both SNF2L transcript and SNF2L protein levels are rapidly increased in granulosa cells of the mouse ovary 8 h after human chorionic gonadotropin treatment, and continue to be expressed 36 h later within the functional corpus luteum. We demonstrate a physical interaction between SNF2L and the progesterone receptor A isoform, which regulates progesterone receptor-responsive genes required for ovulation. Moreover, chromatin immunoprecipitation demonstrated that, after gonadotropin stimulation, SNF2L is associated with the proximal promoter of the steroidogenic acute regulatory protein (StAR) gene, a classic marker of luteinization in granulosa cells. Interaction of SNF2L with the StAR promoter is required for StAR expression, because small interfering RNA knockdown of SNF2L prevents the activation of the StAR gene. Our results provide the first indication that ISWI chromatin remodeling proteins are responsive to the LH surge and that this response is required for the activation of the StAR gene and the overall development of a functional luteal cell.
Mullerian Inhibiting Substance Regulates Androgen-Induced Gene Expression and Growth in Prostate Cancer Cells through a Nuclear Factor-κB-Dependent Smad-Independent Mechanism
Authors: Tran Trinh T. , Segev Dorry L. , Gupta Vandana , Kawakubo Hirofumi , Yeo Giminna , Donahoe Patricia K. , Maheswaran Shyamala 
Published: June 2006

AbstractMullerian inhibiting substance (MIS), a member of the TGFβ superfamily, causes regression of the Mullerian duct in male embryos. The presence of MIS type II and type I receptors in tissues and cell lines derived from the prostate suggests that prostate is a likely target for MIS. In this report, we demonstrate that MIS inhibits androgen-stimulated growth of LNCaP cells and decreases their survival in androgen-deprived medium by preventing cell cycle progression and inducing apoptosis. Expression of dominant-negative Smad1 reversed the ability of MIS to decrease LNCaP cell survival in androgen-deprived medium but not androgen-stimulated growth, whereas abrogation of nuclear factor-κB (NFκB) activation ablated the suppressive effects of MIS on both androgen-stimulated growth and androgen-independent survival. The effect of MIS on androgen-induced growth was not due to changes in androgen receptor expression. However, MIS suppressed androgen-stimulated transcription of prostate-specific antigen; ablation of NFκB activation reversed MIS-mediated suppression of prostate-specific antigen. These observations suggest that MIS regulates androgen-induced gene expression and growth in prostate cancer cells through a NFκB-dependent but Smad1-independent mechanism. Thus, MIS, in addition to potentially regulating prostate growth indirectly by suppressing testicular testosterone synthesis, may also be a direct regulator of androgen-induced gene expression and growth in the prostate at the cellular level.
Materials processing at atmospheric pressure: Nonequilibrium effects on nanotechnology and mega-industries
Authors: Nozaki Tomohiro , Okazaki Ken 
Published: June 2006

Abstract
Applications of atmospheric pressure nonequilibrium plasmas, because of their special advantages of forming reactive plasmas in a simple reactor, are spreading into various engineering fields, not only of materials processing, but also into energy and environment areas. Our group has explored new applications of both filamentary and diffuse barrier discharges, including the establishment of appropriate modeling, which enables better optimization of given plasma processes. More recently, microplasmas produced in submillimeter to micrometer reactors are also highlighted in association with atmospheric pressure nonequilibrium plasma because such small-scale plasmas frequently require high-density media to produce. This paper overviews our recent projects: (1) steam reforming of methane using filamentary barrier discharge; (2) deposition of carbon nanotubes in atmospheric pressure radio frequency discharge (APRFD); and (3) synthesis of silicon nanoparticles using microplasma.
What do we know about long laminar plasma jets?
Authors: Chen Xi , Pan Wenxia , Meng Xian , Cheng Kai , Xu Dong-Yan , Wu Chengkang 
Published: June 2006

Abstract
Silent and stable long laminar plasma jets can be generated in a rather wide range of working parameters. The laminar flow state can be maintained even if considerable parameter fluctuations exist in the laminar plasma jet or if there is an impact of laterally injected particulate matter and its carrier gas. The attractive special features of laminar plasma jets include extremely low noise level, less entrainment of ambient air, much longer and adjustable high-temperature region length, and smaller axial gradient of plasma parameters. Modeling results show that the laminar plasma jet length increases with increasing jet inlet velocity or temperature and the effect of natural convection on laminar plasma jet characteristics can be ignored, consistent with experimental observations. The large difference between laminar and turbulent plasma jet characteristics is revealed to be due to their different laws of surrounding gas entrainment. Besides the promising applications of the laminar plasma jet to remelting and cladding strengthening of the metallic surface and to thermal barrier coating preparation, it is expected that the laminar plasma jet can become a rather ideal object for the basic studies of thermal plasma science owing to the nonexistence of the complexity caused by turbulence.
Plasma-assisted combustion
Authors: Starikovskii A. Yu. , Anikin N. B. , Kosarev I. N. , Mintoussov E. I. , Starikovskaia S. M. , Zhukov V. P. 
Published: June 2006

Abstract
This paper presents an overview of experimental and numerical investigations of the nonequilibrium cold plasma generated under high overvoltage and further usage of this plasma for plasma-assisted combustion.
Here, two different types of the discharge are considered: a streamer under high pressure and the so-called fast ionization wave (FIW) at low pressure.
The comprehensive experimental investigation of the processes of alkane slow oxidation in mixtures with oxygen and air under nanosecond uniform discharge has been performed. The kinetics of alkane oxidation has been measured from methane to decane in stoichiometric and lean mixtures with oxygen and air at room temperature under the action of high-voltage nanosecond uniform discharge.
The efficiency of nanosecond discharges as active particles generator for plasma-assisted combustion and ignition has been investigated. The study of nanosecond barrier discharge influence on a flame propagation and flame blow-off velocity has been carried out. With energy input negligible in comparison with the burner's chemical power, a double flame blow-off velocity increase has been obtained. A signicant shift of the ignition delay time in comparison with the autoignition has been registered for all mixtures.
Detonation initiating by high-voltage gas discharge has been demonstrated. The energy deposition in the discharge ranged from 70 mJ to 12 J. The ignition delay time, the velocity of the flame front propagation, and the electrical characteristics of the discharge have been measured during the experiments. Under the conditions of the experiment, three modes of the flame front propagation have been observed, i.e., deflagration, transient detonation, and Chapman-Jouguet detonation. The efficiency of the pulsed nanosecond discharge to deflagration-to-detonation transition (DDT) control has been shown to be very high.
Opioid Disposition in Human Sweat after Controlled Oral Codeine Administration
Authors: Schwilke Eugene W , Barnes Allan J , Kacinko Sherri L , Cone Edward J , Moolchan Eric T , Huestis Marilyn A 
Published: June 2006

AbstractBackground: Characterization of opioid excretion in sweat is important for accurate interpretation of sweat tests in drug treatment, criminal justice, and workplace drug testing programs.Methods: Participants (n = 20) received placebo, 3 low (60 mg/70 kg) or 3 high (120 mg/70 kg) codeine sulfate doses (used as a model for opioid excretion) within 1 week. Codeine and metabolites in sweat were collected with PharmChek® Sweat Patches; hourly patches were applied for 1 to 15 h (n = 775) and weekly patches for 7 days (n = 118). Patches were analyzed by solid-phase extraction and gas chromatography–mass spectrometry for codeine, norcodeine, morphine, normorphine, and 6-acetylmorphine. Limits of quantification were 2.5 ng/patch (codeine and morphine) and 5 ng/patch (other analytes).Results: Codeine was the only analyte identified in 12.6% of hourly patches and 83.3% of weekly sweat patches worn during dosing. Weekly patch concentrations (SD) were 38.6 (59.9) ng/patch [median (range), 15.9 (0–225.1) ng/patch] for low and 34.1 (32.7) ng/patch [24.0 (0–96.2) ng/patch] for high codeine doses. Codeine detected 1 week after dosing was 4.6 (5.3) ng/patch [median (range), 4.0 (0–17.1) ng/patch; n = 11] after low and 7.7 (7.1) ng/patch [6.9 (0–20.5) ng/patch; n = 10] after high doses. In total, 2.6% of hourly, 38.5% of low-dose, and 45.5% of high-dose weekly patches contained codeine at the proposed Substance Abuse and Mental Health Services Administration cutoff.Conclusions: Codeine was the only analyte detected, at highly variable concentrations, up to 2 weeks after dosing. These results are consistent, considering the complex processes of codeine deposition in sweat. Sweat testing is a useful alternative technique for qualitative monitoring of opioid use.
Pseudoleptobothrium aptychotremae Young, 1967 (Monogenea, Microbothriidae) redescribed from a new host, Trygonorrhina fasciata (Rhinobatidae) in South Australia with a description of the larva and post-larval development
Authors: Glennon Vanessa , Chisholm Leslie , Whittington Ian 
Published: June 2006

AbstractThe adult of Pseudoleptobothrium aptychotremae Young, 1967 (Monogenea, Microbothriidae) is redescribed from the dermal denticles of the southern fiddler ray, Trygonorrhina fasciata (Rhinobatidae) collected off Adelaide, South Australia. This is a new host and locality record. The anatomy of the larva is described from observations of live larvae and the presence of six needle-like spicules in the larval haptor is confirmed. The development of P. aptychotremae is also described.
Description of a new species of Dolichorchis (Digenea, Diplostomidae) in the cocoi heron, Ardea cocoi (Aves, Ardeidae), from Argentina
Authors: Lunaschi Lía , Drago Fabiana 
Published: June 2006

AbstractDolichorchis lacombeensis sp. nov., a digenean parasite of the gut of the cocoi heron, Ardea cocoi (L.), is described as a new species from Buenos Aires Province, Argentina. This new species most closely resembles D. buteii and D. tregenna in the distribution of the vitelline follicles, which reach the intestinal bifurcation in the forebody. D. buteii can be distinguished from D. lacombeensis sp. nov. by the distribution of the vitelline follicles in the hindbody, which are concentrated in midline, by the presence of a sphincter in genital pore and by the size of holdfast organ and posterior testis, which are larger, (240–400 × 176–240 and 315–464 × 240–410 µm, respectively). D. tregenna differ from the new species by their larger measurements (pseudosuckers’ length 90–100, pharynx 52–90 × 50–70 and eggs 89–104 × 48–68 µm).
Scolex development, morphology and mode of attachment of Wenyonia virilis Woodland, 1923 (Cestoidea, Caryophyllidea)
Authors: Ibraheem Mohammed , Mackiewicz John 
Published: June 2006

AbstractDevelopment and morphology of the scolex and mode of attachment of Wenyonia virilis Woodland, 1923, a caryophyllaeid cestode from the silurid Nile fish Synodontis schall (Bloch et Schneider, 1801), were studied by means of light and scanning electron microscopy (SEM). Scolex and genital primordia changes through four stages of juvenile development are described. Longitudinal ridges do not appear on the scolex until the cestode has well defined genital primordia. This is in stark contrast to other caryophyllidean genera in which the basic morphology of the adult scolex becomes evident at the procercoid stage in the oligochaete intermediate host. The scolex of the adult has 13 to 19 prominent longitudinal ridges and deep furrows that come together at the apex to form an apical ring, a protrusible terminal introvert within the apical ring that forms a deep apical pouch when fully retracted, and a central group of Faserzellen. The scolex of W. virilis appears similar to the rugomonobothriate scolex of another African caryophyllid, Monobothrioides chalmersius (Woodland, 1924). Comparisons are made with other caryophyllideans having a scolex with a terminal structure: Monobothrium Diesing, 1863, Djombangia Bovien, 1926 and Caryoaustralus Mackiewicz et Blair, 1980. The terminal introvert may be responsible for attachment in early juvenile stages, but may be supplemented by the longitudinal ridges and furrows later in development. Host tissue appears to be drawn into these furrows that function as weak organs of attachment. We could not determine how the introvert of adult worms functions in attachment. At the site of attachment, the mucosa showed necrosis and degeneration and the submucosa exhibited vacuolization and infiltration with lymphocytes and leucocytes.
A morphological study of Acanthocephaloides propinquus (Acanthocephala, Arhythmacanthidae) parasitising gobiid fishes (Teleostei, Gobiidae) in the northwestern Black Sea
Authors: Kvach Yuriy 
Published: June 2006

AbstractMorphological data for Acanthocephaloides propinquus (Arhythmacanthidae) from gobiid fishes from the northwestern Black Sea are presented. Individuals from the Black Sea differ from the descriptions based on Mediterranean specimens in having 4–5 proboscis hooks per row in the former and 5–6 in the latter. The size of the cuticular spines is rejected as a diagnostic character for A. propinquus because their length varies in a wide range (3.0–7.5 µm). The diagnostic characters for identifying A. propinquus include the presence of small culticular spines, the testes located in the central part of the body and an acanthor having a single hooklet lacking a root.
Distribution patterns and interactions of cestodes in the spiral intestine of the narrownose smooth-hound shark, Mustelus schmitti Springer, 1939 (Chondrichthyes, Carcharhiniformes)
Authors: Alarcos Ana , Ivanov Verónica , Sardella Norma 
Published: June 2006

AbstractThe distribution patterns and the cestode species interactions within the spiral intestine of 20 specimens of Mustelus schmitti from coastal waters off Mar del Plata, Argentina were studied. Six cestode species were found: Tetraphyllideans Calliobothrium barbarae, C. australis, C. lunae and Orygmatobothrium schmittii, diphyllidean Echinobothrium notoguidoi and trypanorhynch Eutetrarhynchus vooremi. The most common number of parasite species per host was 3. Brillouin’s diversity index ranged from 0.1 to 1.2 Berger-Parker dominance index indicated that C. barbarae was the dominant species, followed by O. schmittii and C. australis. Calliobothrium barbarae, C. australis and O. schmittii presented a broad distribution along the spiral intestine, whereas C. lunae, E. notoguidoi and E. vooremi showed a more restricted niche breadth. In general, the Renkonen’s index showed no evidence of niche overlap in the range of distribution of the different species. In most of the infracommunities, intraspecific aggregation was stronger than interspecific aggregation, indicating that competition may play a little role. The distribution patterns of the Calliobothrium specimens concurs with the predictions of attachment sites for Calliobothrium species made by previous authors.
Three species of Philometra (Nematoda, Philometridae) from marine fishes off Corsica, France
Authors: Moravec František , Ternengo Sonia , Levron Céline 
Published: June 2006

AbstractGravid or subgravid females of the following three species belonging to the nematode genus Philometra were collected from marine perciform fishes of the Bonifacio Strait Marine Reserve, Corsica, France: Philometra justinei sp. nov. (prevalence 1.5%, intensity 11) and Philometra sp. (prevalence 3%, intensity 2) from the abdominal cavity and gonads, respectively, of the striped red mullet Mullus surmuletus (Mullidae), and Philometra serranellicabrillae Janiszewska, 1949 (prevalence 27%, intensity 2–6) from the gonads of the comber Serranus cabrilla (Serranidae). The newly described species, P. justinei, is mainly characterized by the absence of an anterior bulbous inflation of the oesophagus, body length of the gravid female (196 mm), conspicuously large amphids, number and distribution of cephalic papillae, and the morphology of larvae. It is the second known species of Philometra parasitizing fishes of the family Mullidae and the ninth species of this genus reported from marine fishes of the Mediterranean region. P. serranellicabrillae, studied for the first time by SEM, is redescribed.
A review of the European Harpirhynchidae (Acari, Prostigmata) with the description of a new species
Authors: Bochkov Andre , Literák Ivan 
Published: June 2006

AbstractRecords of the European Harpirhynchidae Dubinin, 1957 (Acari, Prostigmata) are summarized and briefly discussed. This family is represented in Europe by 23 species belonging to three subfamilies, Harpirhynchinae (18 species recorded), Harpypalpinae Fain, 1972 (4 species recorded), and Ophioptinae Southcott, 1956 (1 species recorded). A new species Harpirhynchus dusbabeki sp. nov. from the bearded tit Panurus biarmicus (L., 1758) (Passeriformes, Timaliidae) in Slovakia is described. This new species differs morphologically from the two similar congeneric species, H. nidulans Nitzsch, 1818 and H. galeridae Fain, Bochkov et Mironov, 1999, by having setae 3a and two setae on both genua I and II.
Genetic and environmental sources of continuity and change in teacher‐rated aggression during early adolescence
Authors: Vierikko Elina , Pulkkinen Lea , Kaprio Jaakko , Rose Richard J. 
Published: June 2006

AbstractGenetic and environmental sources of continuity and change in aggression were studied in a sample of 1,041 twin pairs (364 monozygotic; 348 same‐sex dizygotic; and 329 opposite‐sex dizygotic) as part of an ongoing, population‐based Finnish twin‐family study. At ages 12 and 14, the twins' aggression was assessed by their classroom teachers, using a rating form of the Multidimensional Peer Nomination Inventory. Genetic and environmental sources of continuity and change were studied by fitting a longitudinal bivariate Cholesky decomposition model. Longitudinal model‐fitting results indicated that both genetic and environmental factors influenced continuity in aggression during this 2‐year period, but the age‐to‐age correlation of these factors differed by sex. Continuity in boys' aggression was mediated by genes and common environmental factors; in girls, in contrast, continuity was due primarily to common environmental, and to a lesser degree, unique environmental factors. Genes and unique environments contributed to change in aggression in both sexes. Aggr. Behav. 31:1–13, 2006. © 2006 Wiley‐Liss, Inc.
Transient displacement of Newtonian liquids by gas in periodically constricted tubes
Authors: Dimakopoulos Yannis , Tsamopoulos John 
Published: June 2006

AbstractThe displacement of viscous liquids by pressurized gas from harmonically undulated tubes of finite length is examined. This unsteady process gives rise to a long open bubble of varying radius, increasing length and surrounded by the liquid. In general, the thickness of the liquid film that remains on the tube wall is nonuniform. Under creeping flow conditions, it varies periodically, but with a phase difference from the tube radius. The liquid fraction remaining in each periodic segment of the tube increases as the ratio between the minimum and maximum of the tube radius S decreases, whereas it tends to the well‐known asymptotic value for straight tubes as S → 1, or as the wavelength of the tube undulation increases, although here the flow is accelerating. At high‐values of the Reynolds number, the film thickness increases with the axial distance, and the periodicity of the flow field ahead of the bubble tip, which exists under creeping flow conditions, is broken. At even higher Reynolds numbers, recirculating vortices develop inside each tube expansion and when S also decreases significantly, nearly isolated bubbles are formed in each tube segment. The location of the bubble tip can be monitored by examining the time variation of the pressure at the tube wall. © 2006 American Institute of Chemical Engineers AIChE J, 2006
Stratification based on language‐related endophenotypes in autism: Attempt to replicate reported linkage
Authors: Spence Sarah J. , Cantor Rita M. , Chung Lien , Kim Sharon , Geschwind Daniel H. , Alarcón Maricela 
Published: June 2006

AbstractThe identification of autism susceptibility genes has been hampered by phenotypic heterogeneity of autism, among other factors. However, the use of endophenotypes has shown preliminary success in reducing heterogeneity and identifying potential autism‐related susceptibility regions. To further explore the utility of using language‐related endophenotypes, we performed linkage analysis on multiplex autism families stratified according to delayed expressive speech and also assessed the extent to which parental phenotype information would aid in identifying regions of linkage. A whole genome scan using a multipoint non‐parametric linkage approach was performed in 133 families, stratifying the sample by phrase speech delay and word delay (WD). None of the regions reached suggested genome‐wide or replication significance thresholds. However, several loci on chromosomes 1, 2, 4, 6, 7, 8, 9, 10, 12, 15, and 19 yielded nominally higher linkage signals in the delayed groups. The results did not support reported linkage findings for loci on chromosomes 7 or 13 that were a result of stratification based on the language delay endophenotype. In addition, inclusion of information on parental history of language delay did not appreciably affect the linkage results. The nominal increase in NPL scores across several regions using language delay endophenotypes for stratification suggests that this strategy may be useful in attenuating heterogeneity. However, the inconsistencies in regions identified across studies highlight the importance of increasing sample sizes to provide adequate power to test replications in independent samples. © 2006 Wiley‐Liss, Inc.