bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of wharton's duct stenosis in floor of the mouth cancers excised with scalpel or cautery VS CO2 laser
Authors: Mihail Radu , Zajtchuk Joan T. , Davis R. Kim 
Published: February 2007

AbstractSurgery of the floor of the mouth (FOM) using a scalpel or cautery has produced stenosis of Wharton's duct, necessitating further surgery because of painful enlargement to the gland or suspected metastasis. The laser has been proposed as an alternative method that might avoid this complication. A retrospective study comparing these excisional techniques was done at Walter Reed Army Medical Center between 1973 and 1983. Of a total of 58 lesions, 35 were T1NOMO and 23 were T2NOMO (two synchronous lesions being present). Of 35 lesions excised with a scalpel, 11 had an associated submandibular gland resection. Of the remaining 25, two developed secondary duct stenosis. Of 10 lesions excised with cautery, three had an associated excision of the submandibular gland. Of the remaining seven, two developed stenosis and one required subsequent excision of the gland. Of 12 lesions excised with laser, four developed stenosis and two required subsequent excision of the gland. Laser excision appears to be of no advantage in avoiding further surgery of the submandibular gland. A submandibular gland resection at the time of the original resection of T1NO or T2NO cancers of the FOM does not appear warranted.
Histoplasmosis presenting as a neck mass
Authors: Belani Anusha , Shands Joseph W. 
Published: February 2007

AbstractA unilateral neck mass is an unusual clinical presentation for histoplasmosis. A patient with a large, unilateral neck mass caused by Histoplasma capsulatum is presented to alert readers to such a possibility and to illustrate some of the difficulties in diagnosing and managing the disease.
Radioimmunoscintigraphy of squamous carcinomas of the head and neck
Authors: Soo K. C. , Ward M. , Roberts K. R. , Keeling F. , Carter R. L. , McCready V. R. , Ott R. J. , Powell E. , Ozanne B. , Westwood J. H. , Gusterson B. A. 
Published: February 2007

AbstractA pilot study was carried out to assess the value of a radiolabeled antibody against epidermal growth factor receptor (EGFR1) in localizing tumors in patients with squamous carcinomas of the head and neck. Positive images of large tumours (> 3 cm diameter) were obtained in 8 of 11 patients after intravenous administration of 111indium‐labeled EGFR1. Two patients gave equivocal results, while negative scans were obtained from the patient with the smallest tumor (1 cm diameter). There were no false‐positive images. The success of this study in localizing relatively large squamous carcinomas indicates that the antibody should be evaluated in patients with smaller tumors to establish the limits of detection of the technique.
Lymph node invasion in hypopharynx and lateral epilarynx carcinoma: A prognostic factor
Authors: Lefebvre J. L. , Castelain B. , De Torre J. C. La , Delobelle‐Deroide A. , Vankemmel B. 
Published: February 2007

AbstractHypopharynx (HC: pyriform fossa, postcricoïd area, and posterior wall) and lateral epilarynx carcinomas (LEC: aryepiglottic fold, pharyngoepiglottic fold, and arytenoid) have a high tendency to cervical lymph node invasion. Such nodal extension is a well‐known prognostic factor. This study is based on a retrospective review of 884 clinical records of previously untreated HC or LEC. Seventy percent of patients revealed palpable nodes at their first examination, with a higher percentage for HC (73%) than LEC (62%). The 5‐year survival rate was divided by three in the presence of contralateral, bilateral, or fixed nodes, or in cases of nodes exceeding 3 cm. Multiple positive nodes, extracapsular spread, or lower‐neck positive nodes significantly decreased survival, doubled the number of neck recurrences, and tripled the number of distant metastases while control at the primary site remained unvaried.
Injury to the orbital plate of the frontal bone
Authors: Potter James A. , Siddoway John R. , Mathog Robert H. 
Published: February 2007

AbstractTwelve cases of fracture of the orbital plate of the frontal bone are reviewed to clarify this important clinical problem and to suggest satisfactory methods of management. Common signs and symptoms include forehead laceration and deformity, and fracture of the frontal sinus. Loss of vision can occur, and in the seeing eye, diplopia can develop in several fields of gaze. Downward or upward projection of the orbital plate of the frontal bone can cause exophthalmos or enophthalmos. Cerebrospinal fluid leak, with or without meningitis, and seizures can also be part of the syndrome. Effective treatment consists of repairing or obliterating the frontal sinus, reducing the orbital root fracture, and repositioning the globe. Rib or iliac crest grafts, acrylic implants, and temporalis muscle‐galea flaps are useful in correcting the deformity and restoring appropriate function. Long‐term follow‐up examinations are an important part of patient care.
Pharyngeal repair after laryngopharyngectomy: 4‐year experience
Authors: Rifai Mohamed , Amer Faisal , Abdel‐Meguid Hassan , Mebed Hassan 
Published: February 2007

AbstractThe most common forms of surgical intervention carried out at the National Cancer Institute of Cairo for patients initially seen with hypopharyngeal carcinoma are (1) laryngopharyngectomy and pharyngeal repair using the pectoralis major myocutaneous flap (PMMF) and (2) extrapleural total pharyngolaryngoesopha‐gectomy with gastric transposition (GT) and pharyngogastrostomy. The advantages and disadvantages with both techniques will be discussed on the basis of results of 69 patients with different tumor distributions over a 4‐year period.
Esthesioneuroblastoma metastatic to the trachea
Authors: Franklin Daniel , Miller Robert H. , Kim Bloom M. G. , Easley James , Stiernberg Charles M. 
Published: February 2007

AbstractEsthesioneuroblastoma is an uncommon nasal neoplasm of neural crest origin, which is recognized for its propensity for local recurrence and distant dissemination by both lymphatic and hematogenous routes. Hematogenous spread occurs most frequently to the lungs and bones, but metastases to the liver, spleen, scalp, face, breast, adrenal, aorta, and ovary have been reported. We present a patient who developed metastatic esthe‐sioneuroblastoma of the trachea 1 year after successful craniofacial resection of his primary tumor. The patient was treated by YAG laser resection of the metastatic tumor followed by radiotherapy. He was free of tracheal disease 1 year after treatment of the metastases.
Induction chemotherapy for advanced head and neck cancers: A literature review
Authors: Chang Tsuling Michele 
Published: February 2007

AbstractInduction chemotherapy before surgery and/or radiotherapy for previously untreated head and neck carcinoma results in greater response rates than chemotherapy for recurrent head and neck carcinomas. Its theoretical advantages are presented. Most studies using induction chemotherapy are nonrandomized, uncontrolled pilot efforts. Multiple‐drug regimens result in greater response rates than single agents, and multiple courses result in greater response rates than single courses. Prognostic factors are discussed. Toxicities are tolerable, except for several reported regimens combining cisplatin, bleomycin, and metho‐trexate. Induction chemotherapy for head and neck cancer is promising and needs further studies with controlled, randomized trials with long‐term follow‐up.
T1‐T2 vocal cord carcinoma: A basis for comparing the results of radiotherapy and surgery
Authors: Mendenhall William M. , Parsons James T. , Stringer Scott P. , Cassisi Nicholas J. , Million Rodney R. 
Published: February 2007

AbstractThis is an analysis of 304 patients with invasive, previously untreated T1‐T2 squamous cell carcinoma of the glottic larynx treated with radiotherapy between October 1964 and December 1984. All patients had a minimum 2‐year follow‐up and 82% had at least 5 years of follow‐up. Patients were excluded from the analysis of local control if they died within 2 years of treatment with the primary site continuously disease‐free. Patients were staged according to the AJCC system and stratified by the surgical procedure that would have been required to resect the tumor. Stage T2 was subdivided into two subsets: T2a (normal mobility) and T2b (decreased mobility). The rates of local control with radiotherapy and the ultimate rates of local control, including patients salvaged surgically for a local recurrence, were as follows: T1, 159 of 171 (93%) and 166 of 171 (97%); T2a, 50 of 65 (77%) and 63 of 65 (97%); and T2b, 31 of 43 (72%) and 38 of 43 (88%). The rate of local control for patients with T1 lesions limited to one cord was not influenced by tumor extension to the anterior commissure. The overall incidence of serious complications was 5 of 304 (1.6%). The 5‐year determinate survival rates were as follows: T1, 130 of 134 (97%); T2a, 43 of 46 (93%); and T2b, 29 of 33 (88%).
Retropharyngeal infiltrating lipoma‐A case report
Authors: Eisele David W. , Landis George H. 
Published: February 2007

AbstractInfiltrating lipoma is an unusual, benign, slowly growing neoplasm that characteristically infiltrates skeletal muscle and has a propensity for local recurrence if incompletely excised. These tumors rarely occur in the head and neck. A case of infiltrating lipoma of the retropharynx is reported. The clinical, histologic, surgical, and radiologic aspects of the lesion are reviewed. The use of magnetic resonance imaging of this tumor is presented.
Allylic Alcohols as Substrate for Ruthenium‐Catalyzed CC Coupling Allylation Reactions. Preliminary Communication
Authors: Nieves Ignacio Fernández , Schott Danièle , Gruber Stefan , Pregosin Paul S. 
Published: February 2007

AbstractAllylic alcohols, rather than halides, acetates, or carbonates can be used directly in the Friedel–Crafts‐type coupling with various phenols. The use of a RuIV, rather than a RuII, precursor promotes the formation of one H+ per cycle so that a large excess of acid is never present in the reaction mixture. Consequently, the leaving group in the oxidative addition reaction is H2O, thereby avoiding the production of an unnecessary by‐product.
Phenolic Compounds from Scorzonera tomentosa L.
Authors: Sarı Aynur , Zidorn Christian , Ellmerer Ernst P. , Özgökçe Fevzi , Ongania Karl‐Hans , Stuppner Hermann 
Published: February 2007

AbstractFrom the subaerial parts of S. tomentosa L. (Asteraceae), two new dihydroisocoumarins, compounds 1 and 2, a new phthalide, 3, and a new stilbene derivative, 4, were isolated, together with four known compounds, (±)‐hydrangenol (5), (−)‐hydrangenol 4′‐O‐β‐glucoside (6), (±)‐hydramacrophyllol A (7), and (±)‐hydramacrophyllol B (8). All secondary metabolites were identified on the basis of physicochemical, spectroscopic, and mass‐spectrometric data. The known compounds 5–8 were isolated for the first time from this species.
New Iridoid Glycosides from Lamium eriocephalum subsp. eriocephalum
Authors: Yalçın Funda Nuray , Ersöz Tayfun , Avcı Kürşat , Gotfredsen Charlotte H. , Jensen Søren R. , Çalış İhsan 
Published: February 2007

AbstractTwo new iridoid glycosides, eriobioside (1) and lamerioside (2), were isolated from the aerial parts of Lamium eriocephalum subsp. eriocephalum, along with the two known compounds lamiide (3) and ipolamiide (4). Their structures were elucidated by spectroscopic methods (UV, 1D‐ and 2D‐NMR) and by mass spectrometry (HR‐ESI‐MS).
β‐Cyclodextrin‐Supported, Completely Regioselective Ring Opening of Thiiranes with Thiophenol in Water
Authors: Reddy Majjigapu Somi , Surendra Karavadi , Krishnaveni Neelam Srilakshmi , Narender Mendu , Rao Kakulapati Rama 
Published: February 2007

AbstractThiolysis of thiiranes I with thiophenols II is performed efficiently in the presence of β‐cyclodextrin in water with high regioselectivity (Scheme, Table).
Estimation of irrigation flow by hydrograph analysis in a complex agricultural catchment in subtropical China
Authors: Tang Jia‐Liang , Zhang Bin , Zepp Harald 
Published: February 2007

AbstractEstimating the amount of irrigation water is challenging at the catchment scale because of the difficulties in direct measurement and interactions between the flow components. The objectives of the study were to characterize the catchment flows in an agricultural catchment with an irrigation system in subtropical China and to estimate catchment irrigation flow using hydrograph analysis methods. A weighting model and multiple regression models were established to estimate catchment irrigation outflow according to the hydrographs of the inflows and outflows of the catchment. The multiple regression models took into consideration the drainage time of base flow, resulting in better estimation on an event and annual basis. Using the MR‐6d method, the estimated irrigation outflows amounted to 3700 mm, 2600 mm and 2760 mm during 2001, 2002 and 2003 respectively, which covered 70%, 60% and 64% respectively of the total catchment outflows in the corresponding years. Copyright © 2007 John Wiley & Sons, Ltd.
Runoff dependent erosivity and slope length factors suitable for modelling annual erosion using the Universal Soil Loss Equation
Authors: Kinnell P. I. A. 
Published: February 2007

AbstractDespite revisions and refinements, the Revised Universal Soil Loss Equation (RUSLE), which is the revised version of the Universal Soil Loss Equation (USLE), over predicts small annual soil losses and under predicts large annual soil losses. To some large extent, this results from the equation over estimating small event soil losses and under estimating large event soil losses. Replacing the USLE/RUSLE event erosivity index (EI30) by the product of EI30 and the runoff ratio (QR) significantly reduces the errors in estimating event erosion when runoff is measured, but the USLE‐M, the USLE variant that uses the QREI30 index, requires crop and support practice factors that differ from those used in the RUSLE. The theory which enables the QREI30 index to be used in association with the RUSLE crop and support practice factors is presented. In addition, the USLE/RUSLE approach was developed for conditions where runoff is produced uniformly over a hill slope. A runoff dependent slope length factor that takes account of runoff variations over a hill slope is presented and demonstrated for the situation where runoff from a low runoff producing area passes onto an area where runoff is produced more readily. Copyright © 2007 John Wiley & Sons, Ltd.
Sun exposure and malignant lymphoma: A population‐based case–control study in Germany
Authors: Weihkopf Thomas , Becker Nikolaus , Nieters Alexandra , Mester Birte , Deeg Evelin , Elsner Gine , Blettner Maria , Seidler Andreas 
Published: February 2007

AbstractAlthough some causes for malignant lymphoma are known their etiology is not well understood so far. We analyze the relationship between sun exposure and malignant lymphoma in a multicenter, population‐based case–control study. Patients with malignant lymphoma (n = 710, 18–80 years) were prospectively recruited in 6 study regions in Germany. For each case, a gender, region and age‐matched control was drawn from population‐registers. In personal interviews, lifetime holidays spent in sunny climate, outdoor leisure activities and sunbed or sunlamp use were recorded. On basis of job task‐specific supplementary questionnaires, an occupational physician assessed the cumulative working time outside. Odds ratios (OR) and 95%‐confidence‐intervals (CI) were calculated using conditional logistic regression analysis, adjusted for smoking and alcohol consumption. To increase statistical power, patients with specific lymphoma subentities were additionally compared with the entire control group using unconditional logistic regression. We observed a reduced overall lymphoma risk among subjects having spent vacations at sunny climates or frequently used sunbeds or sunlamps. The analysis of lymphoma subentities revealed similar results with the exception of T‐NHL and follicular lymphoma which were positively associated with outdoor leisure activities. While cumulative working time outside appeared unrelated to NHL overall and most subentities, it was negatively associated with follicular lymphoma and weakly positively to HL. This data suggest that exposure to natural and artificial ultraviolet radiation may reduce the OR for lymphoma in this study population. © 2007 Wiley‐Liss, Inc.
Polymorphisms in one‐carbon metabolism and trans‐sulfuration pathway genes and susceptibility to bladder cancer
Authors: Moore Lee E. , Malats Núria , Rothman Nathaniel , Real Francisco X. , Kogevinas Manolis , Karami Sara , García‐Closas Reina , Silverman Debra , Chanock Stephen , Welch Robert , Tardón Adonina , Serra Consol , Carrato Alfredo , Dosemeci Mustafa , García‐Closas Montserrat 
Published: February 2007

AbstractWe have previously reported significant inverse associations between bladder cancer risk and dietary intake of vitamins B2, B6, B12, folate and protein in a hospital‐based bladder cancer case‐control study conducted in Spain (1,150 cases;1,149 controls). Because these dietary factors are involved in the one‐carbon metabolism pathway, we evaluated associations between bladder cancer risk and 33 single nucleotide polymorphisms (SNPs) in 8 genes (CBS, CTH, MTHFR, MTR, MTRR, SHMT1, SLC19A1andTYMS) and interactions with dietary variables involved in this pathway. Two SNPs in theCTHgene were significantly associated with bladder cancer risk. OR (95% CI) for heterozygous and the homozygous variants compared to homozygous wild‐type individuals were: 1.37 (1.04–1.80) IVS3‐66 A > C and 1.22 (1.02–1.45) IVS10‐430 C > T. Because theCTHgene is important for glutathione synthesis, we examined interactions with theGSTM1gene, which codes for glutathione S‐transferase μu. Increased risk for individuals with the IVS10‐430 CT or TT genotype was limited to those with theGSTM1null genotype (p‐interaction = 0.02). No other SNPs were associated with risk of bladder cancer. These findings suggest that common genetic variants in the one‐carbon pathway may not play an important role in the etiology of bladder cancer. However, our results provide some evidence that variation in glutathione synthesis may contribute to risk, particularly among individuals who carry a deletion inGSTM1. Additional work is needed to comprehensively evaluate genomic variation inCTHand related genes in the trans‐sulfuration pathway and bladder cancer risk. © 2007 Wiley‐Liss, Inc.
In vivo and in vitro invasiveness of a rat colon‐cancer cell line maintaining E‐cadherin expression: An enhancing role of tumor‐associated myofibroblasts
Authors: Dimanche‐Boitrel Marie Thearèse , Vakaet Luc , Pujuguet Philippe , Chauffert Bruno , Martin Monique S. , Hammann Arlette , Van Roy Frans , Mareel Marc , Martin François 
Published: February 2007

AbstractIn various cell systems, an inverse relationship was found between expression of E‐cadherin, a molecule involved in the Ca2+‐dependent homophylic cell‐to‐cell attachment of epithelial cells, and the capacity to invade extracellular matrix gels or normal tissues in vitro., DHD/K12/TRb (PROb) cells, maintained as a cell line derived from a rat colon carcinoma, homogeneously expressed. in vitro immunoreactive E‐cadherin, which was functional as shown in cell dissociation‐reassociation assays. PROb cells were found to be non‐invasive in 3 different assays in vitro., However, tumors resulting from a s.c. injection of PROb cells into syngeneic BD‐IX rats were invasive, although PROb cells maintained E‐cadherin expression in the tumors. Cells from a freshly dissociated PROb tumor showed, not only PROb cells but also tumor‐associated myofibrobfasts and were able to cross a Matrigel‐coated filter. PROb tumors were indeed infiltrated by numerous myofibroblasts, mainly located at the invasive edge of the tumor. Cells from an established culture of tumor‐infiltrating myofibroblasts were able to confer upon PROb cells invasiveness through Matrigel‐coated filter or into chick‐heart fragments. PROb cells maintained their capacity to express E‐cadherin after myofibroblast‐enhanced Matrigel invasion. Tumor‐associated myofibroblasts, but not PROb cells, secreted a 72‐kDa collagenase that could play a role in tumor‐cell invasion. These results strongly suggest that cells from the tumor stroma, and more specifically myofibroblasts, may be involved in the invasiveness of epithelial tumor cells in vivo, even when E‐cadherin expression prevents tumor‐cell invasiveness in different in vitro assays.
ErbB‐2 expression in estrogen‐receptor‐positive breast‐tumor cells is regulated by growth‐modulatory reagents
Authors: Taverna Daniela , Antoniotti Susanna , Maggiora Piera , Dati Claudio , de Bortoli Michele , Hynes Nancy E. 
Published: February 2007

AbstractIt has previously been shown that, in the estrogen‐receptor‐positive breast‐tumor cell lines T47D and ZR75.1, the erbB‐2 protein and mRNA content are controlled negatively and positively by, respectively, estrogens and anti‐estrogens. Since estrogens have a positive effect on cell proliferation, while anti‐estrogens inhibit cell growth, the results suggested that there may be an inverse correlation between growth and erbB‐2 expression, We have now examined this matter further. The effect of various growth‐modulatory agents including estrogen (E2), progesterone (Pg), retinoic acid (RA), epidermal growth factor (EGF), insulin (Ins), prolactin (Prl), 12‐O‐tetradecanolyl‐phorbol‐13‐acetate (TPA) and dibutyryl‐3′:5′‐cycfic‐AMP (cAMP) on c‐erbB‐2 promoter activity, RNA and protein expression have been examined. The growth stimulators E2 and EGF both reduced the level of erbB‐2 protein. However, while E2 clearly repressed erbB‐2 transcription, in the case of EGF, neither mRNA nor transcription were decreased. Of the agents which inhibit the growth of T47D and ZR75.1 cells—Pg, Prl, cAMP, RA and TPA—only Pg and cAMP caused an increase in the erbB‐2 protein level. Pg and cAMP positively influenced c‐erbB‐2 promoter activity and RNA amount. TPA and RA also increased promoter activity but neither erbB‐2 mRNA nor protein level was enhanced. The erbB‐2 protein expression in cultures of T47D and ZR75.1 cells at different densities was also analyzed. Both the level of erbB‐2 protein and c‐erbB‐2 promoter activity rose markedly in confluent cultures, suggesting a transcriptional mechanism of control. In conclusion, the data suggest that the effects of various agents on erbB‐2 expression are complex and cannot be explained simply as reflecting the growth state of the cells.