bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comprehensive analysis of age of onset and cumulative incidence of mental disorders: A Danish register study
Authors: Beck Christoffer , Pedersen Carsten Bøcker , Plana‐Ripoll Oleguer , Dalsgaard Søren , Debost Jean‐Christophe Philippe , Laursen Thomas Munk , Musliner Katherine Louise , Mortensen Preben Bo , Pedersen Marianne Giørtz , Petersen Liselotte Vogdrup , Yilmaz Zeynep , McGrath John , Agerbo Esben 
Published: March 2024

AbstractBackgroundThe age of onset (AOO), incidence and cumulative incidence of mental disorders are critical epidemiological measures, providing essential insights into the development and course of these disorders across the lifespan. This study aims to provide up‐to‐date estimates of the AOO, age‐specific incidence, and cumulative incidence for a comprehensive range of mental disorders using data from Danish registers.MethodsWe conducted a follow‐up study encompassing all Danish residents from January 1, 2004, to December 31, 2021, totaling 91,613,465 person‐years. Data were sourced from the Danish Psychiatric Central Research Register, identifying individuals treated for various mental disorders in psychiatric hospitals, outpatient departments, and accident/emergency departments, that is, treated in secondary care settings. We investigated specific categories of mental disorders, including substance abuse disorders, schizophrenia, mood disorders, anxiety, eating disorders, borderline personality disorders, intellectual disabilities, pervasive developmental disorders, and behavioral and emotional disorders. Age‐sex‐specific incidence rates were estimated using Poisson generalized linear models, and cumulative incidence was calculated using Aalen–Johansen's competing risks model. The study provides estimates of AOO, incidence, and cumulative incidence for various mental disorders, including their age and sex distributions.ResultsThe cumulative incidence by age 80 years for any mental disorder was 30.72% (95% confidence interval: 30.62%–30.83%) for males and 34.46% (34.35%–34.57%) for females. The most common types of mental disorders were anxiety‐related disorders 16.27% (16.19%–16.36%) for males and 23.39% (23.29%–23.50%) for females, and followed by mood disorder 10.34% (10.27%–10.41%) for males and 16.67% (16.58%–16.77%) for females. For those who develop mental disorder, half will have developed their disorder by approximately age 22 years (median and interquartile range: males 21.37 (11.85–36.00); females 22.55 (16.31–36.08)).ConclusionsApproximately one in three individuals will seek treatment for at least one mental disorder in a secondary care setting by age 80. Given that half of these individuals develop mental disorders before age 22, it is crucial to tailor service planning to meet the specific needs of young individuals. Web‐based interactive data‐visualization tools are provided for clinical utility.
How can sustainable business models distribute value more equitably in global value chains? Introducing “value chain profit sharing” as an emerging alternative to fair trade, direct trade, or solidarity trade
Authors: Bennett Elizabeth A. , Grabs Janina 
Published: March 2024

AbstractGlobal supply chains often distribute value inequitably among the Global North and South. This perpetuates poverty and contributes to indecent work in raw material‐producing countries, thus creating challenges to sustainable development. For decades, corporate social responsibility, social entrepreneurship, and sustainable business model innovations have aimed to distribute value more equitably across global value chains, for instance via fair trade, alternative trade, and direct trade. This article examines a novel and hitherto understudied innovation for equitable value distribution in global supply chains: “value chain profit sharing.” We draw on interview and archival data from two cases of social entrepreneurs working in the coffee sector to develop a generalized model. One of the model's key features is that the entrepreneur pays suppliers in multiple installments that reflect market conditions (as opposed to a single lump sum based on prediction). We show how this can increase value creation, appropriation, and equitable distribution. Although our research suggests that this model may be highly contingent on leaders' skills, resources, sense of place, and accountability to suppliers, we find no evidence that its applications are limited to specific countries or sectors. Our research further extends extant theory by showing how “value chain profit sharing” may relieve some of the tensions often associated with sustainable business models, including distributing value to suppliers while maintaining financial solvency; creating value while pursuing a social mission; providing benefits to suppliers without curtailing their market opportunities; responding to market conditions while maintaining commitments to suppliers; and scaling without diluting benefits. It thereby contributes to the literatures on sustainable business model innovations, equitable value distribution in global supply chains, novel application of revenue‐sharing contracts, and innovative methods of profit sharing. It furthermore provides actionable guidance for social entrepreneurs, corporate social responsibility practitioners, and supplier cooperatives aiming to achieve more equitable value distribution and sustainable supply chains.
Comparison of platelet transfusion effectiveness between Helicobacter pylori‐positive and ‐negative immune thrombocytopenia
Authors: Tabata Shotaro , Hosoi Hiroki , Wan Ke , Sakaki Ayaka , Mushino Toshiki , Murata Shogo , Tomiyama Yoshiaki , Sonoki Takashi 
Published: March 2024

SummaryImmune thrombocytopenia (ITP) is characterized by early platelet destruction and impaired platelet production. Helicobacter pylori (H. pylori) infection seems to contribute to the pathogenesis in certain ITP patients in Japan. We compared the effectiveness of platelet transfusion in severe ITP in the presence or absence of H. pylori. The median corrected count increment (CCI) at 24 h after platelet transfusion (CCI‐24) of the H. pylori‐positive ITP patients was higher than that of the H. pylori‐negative ITP patients (6463 vs. 754, p < 0.001), and the CCI‐1 was also in the same direction but not significant (23 351 vs. 11 578). Multiple regression analyses showed that H. pylori infection was independently associated with CCI‐24. Our study suggests that platelet transfusion may be more effective in H. pylori‐positive ITP patients.
Volatiles of essential oils and yeast derivatives influence mating behaviour of Anastrepha fraterculus males under field cage conditions
Authors: Ruiz M. J. , Juárez M. L. , Jofré Barud F. , Goane L. , Valladares G. A. , Bachmann G. E. , Belliard S. A. , Segura D. F. , López M. L. , Vera M. T. 
Published: March 2024

AbstractThe sterile insect technique (SIT) is used for the management of tephritid fruit fly pests. The South American fruit fly, Anastrepha fraterculus (Wiedemann) (Diptera: Tephritidae), is one potential pest to be targeted by means of SIT. The success of SIT depends, to a large extent, on the sexual performance of sterile males. Various approaches have been evaluated with the aim of improving their sexual performance. These include the exposure to plant‐derived compounds and/or the provision of protein sources in the adults' diet capable of stimulating male mating success. The present study aimed to determine whether exposure to volatiles of Citrus limon (L.) Burm. F. (Rutaceae) essential oil and limonene confers a mating advantage to A. fraterculus laboratory males fed two distinct dietary regimes when competing with wild males for wild females under field cage conditions. Dietary regimes were, one, with non‐hydrolysed brewer's yeast and sugar (1:3 ratio), and the other with brewer's yeast hydrolysate enzymatic and sugar (1:12 ratio). The effect was evaluated in four variables associated with mating success: number of copulas obtained, latency to mate, copula duration, and copula location. Exposure to volatiles did not affect the number of matings achieved, irrespective of the diet given to the males. When laboratory males were fed with brewer's yeast hydrolysate, the effect of volatile exposure was shown in latency to mate, copula duration, and copula location. When the laboratory males were fed with non‐hydrolysed brewer's yeast, the effect of volatile exposure was shown only in copula duration. Laboratory males fed brewer's yeast hydrolysate achieved the same number of matings as wild males, whereas laboratory males fed non‐hydrolysed brewer's yeast had lower performance.
Promoting pain coping skills in haemophilia: A remote intervention integrating exercise and pain education
Authors: Feldberg Glenda , Ricciardi Janaína B. S. , Zorzi Alessandro R. , Yamaguti‐Hayakawa Gabriela G. , Ozelo Margareth C. 
Published: March 2024

AbstractBackgroundChronic joint pain is a significant and widespread symptom in people with haemophilia (PWH). Despite medical advancements, effective pain management remains challenging.AimThis study presents an innovative approach that integrates remote physical exercises, pain neuroscience education, and coping strategies to address chronic pain in PWH.MethodsThe remote intervention consisted of sixteen 5‐min videos encompassing physical exercises for chronic pain management and pain education strategies. These videos formed an 8‐week remote intervention program. Clinical and physical assessments were conducted before and after the intervention.ResultsA total of thirty‐one PWHs, with a median age of 34 years (ranging from 16 to 59 years), completed the remote intervention. The study revealed significant improvements in pain intensity, disability, and physical performance among PWH with chronic pain. Enhanced functional capacity was evident in the Timed Up and Go and Single Leg Stance tests, accompanied by improved scores on the Functional Independence Score in Haemophilia (FISH). Although lacking a control group, our findings are consistent with other successful exercise and pain education programs.ConclusionsThis innovative intervention holds promise for managing chronic pain in PWH, underscoring patient empowerment, education, and collaboration. Notably, our study stands out by uniquely combining pain education and coping strategies, bolstering evidence for effective pain management.
The effects of emicizumab on in vitro coagulation and fibrinolysis parameters in patients with disseminated intravascular coagulation with and without addition of anti‐FVIII antibody
Authors: Onishi Tomoko , Shimo Hanako , Harada Suguru , Nogami Keiji 
Published: March 2024

AbstractBackgroundEmicizumab (Emi) is used as haemostatic prophylaxis for patients with haemophilia A (PwHA). Disseminated intravascular coagulation (DIC) is a condition characterized by persistent systemic activation of coagulation, but there is yet no information on coagulation and fibrinolysis potentials in Emi‐treated PwHA with DIC.AimTo examine the effect of Emi on coagulation and fibrinolysis potentials in HA‐model DIC plasmas.MethodsPlasma from a patient with sepsis‐DIC (seven patients) was treated with anti‐factor (F)VIII monoclonal antibody (HA‐model DIC plasma) and incubated with Emi (50 µg/mL). The plasma was then assessed using clot‐fibrinolysis waveform analysis (CFWA). Coagulation and fibrinolysis parameters were expressed as ratios relative to normal plasma (|min1|‐ratio and |FL‐min1|‐ratio, respectively).Patients and resultsIn case 1, coagulant potential was slightly high and fibrinolytic potential was extremely low, presenting a coagulant‐dominant state (|min1|‐ratio/|FL‐min1|‐ratio: 1.1/.38). In cases 2–5, fibrinolytic potential was not suppressed, but there were marked hypercoagulant potentials, indicating relative coagulant‐dominant states. In case 6, coagulant and fibrinolytic potentials were increased but well balanced (|min1|‐ratio/|FL‐min1|‐ratio: 1.38/1.28). In case 7, both potentials were severely deteriorated in not only CFWA but also the thrombin/plasmin generation assay. The addition of Emi into the HA‐model DIC plasmas increased |min1|‐ratio values in all cases, but the coagulant potentials did not exceed the initial ones (DIC plasma before treatment with anti‐FVIII antibody).ConclusionsThe presence of Emi in the HA‐model DIC plasma improved coagulation potentials, but did not increase coagulation potentials beyond those of DIC plasma in non‐HA states.
Prediction of cardiovascular and renal risk among patients with apparent treatment‐resistant hypertension in the United States using machine learning methods
Authors: Bakris George , Lin Pei (Paul) , Xu Chang , Chen Cindy , Ashton Veronica , Singhal Mukul 
Published: March 2024

AbstractApparent treatment‐resistant hypertension (aTRH), defined as blood pressure (BP) that remains uncontrolled despite unconfirmed concurrent treatment with three antihypertensives, is associated with an increased risk of developing cardiovascular and renal complications compared with controlled hypertension. We aimed to identify the characteristics of aTRH patients with an elevated risk of major adverse cardiovascular events plus (MACE+; defined as stroke, myocardial infarction, or heart failure hospitalization) and end stage renal disease (ESRD). This retrospective cohort study included aTRH patients (BP ≥140/90 mmHg and taking ≥3 antihypertensives) from the United States–based Optum® de‐identified Electronic Health Record dataset and used machine learning models to identify risk factors of MACE+ or ESRD. Patients had claims for ≥3 antihypertensive classes within 30 days between January 1, 2015 and June 30, 2021, and two office BP measures recorded 1–90 days apart within 30 days to 11 months after the index regimen date. Of a total 18 797 070 patients identified with any hypertension, 71 100 patients had aTRH. During the study period (mean 25.5 months), 4944 (7.0%) patients had a MACE+ and 2403 (3.4%) developed ESRD. In total, 22 risk factors were included in the MACE+ model and 16 in the ESRD model, and most were significantly associated with study outcomes. The risk factors with the largest impact on MACE+ risk were congestive heart failure, stages 4 and 5 chronic kidney disease (CKD), age ≥80 years, and living in the Southern region of the United States. The risk factors with the largest impact on ESRD risk, other than pre‐existing CKD, were anemia, congestive heart failure, and type 2 diabetes. The overall study cohort had a 5‐year predicted MACE+ risk of 13.4%; this risk was increased in those in the top 50% and 25% high‐risk groups (21.2% and 29.5%, respectively). The overall study cohort had a predicted 5‐year risk of ESRD of 6.8%, which was increased in the top 50% and 25% high‐risk groups (10.9% and 17.1%, respectively). We conclude that risk models developed in our study can reliably identify patients with aTRH at risk of MACE+ and ESRD based on information available in electronic health records; such models may be used to identify aTRH patients at high risk of adverse outcomes who may benefit from novel treatment interventions.
Depletion of CPNE7 sensitizes colorectal cancer to 5‐fluorouracil by downregulating ATG9B expression
Authors: Xu Weile , Tang Yujie , Yang Yang , Wang Changjing , Liu Chen , Zhang Jianqing , Zhao Lianmei , Wang Guiying 
Published: March 2024

AbstractWe aimed to explore the biological function of CPNE7 and determine the impact of CPNE7 on chemotherapy resistance in colorectal cancer (CRC) patients. According to the Gene Expression Profiling Interactive Analysis database and previously published data, CPNE7 was identified as a potential oncogene in CRC. RT‐qPCR and Western blotting were performed to verify the expression of CPNE7. Chi‐square test was used to evaluate the associations between CPNE7 and clinical features. Cell proliferation, colony formation, cell migration and invasion, cell cycle and apoptosis were assessed to determine the effects of CPNE7. Transcriptome sequencing was used to identify potential downstream regulatory genes, and gene set enrichment analysis was performed to investigate downstream pathways. The effect of CPNE7 on 5‐fluorouracil chemosensitivity was verified by half maximal inhibitory concentration (IC50). Subcutaneous tumorigenesis assay was used to examine the role of CPNE7 in sensitivity of CRC to chemotherapy in vivo. Transmission electron microscopy was used to detect autophagosomes. CPNE7 was highly expressed in CRC tissues, and its expression was correlated with T stage and tumour site. Knockdown of CPNE7 inhibited the proliferation and colony formation of CRC cells and promoted apoptosis. Knockdown of CPNE7 suppressed the expression of ATG9B and enhanced the sensitivity of CRC cells to 5‐fluorouracil in vitro and in vivo. Knockdown of CPNE7 reversed the induction of the autophagy pathway by rapamycin and reduced the number of autophagosomes. Depletion of CPNE7 attenuated the malignant proliferation of CRC cells and enhanced the chemosensitivity of CRC cells to 5‐fluorouracil.
Comparative proteome analysis revealed potential biomarkers and the underlying immune mechanisms in Vibrio‐resistant hybrid grouper, Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂
Authors: Abu Aziz Nurhikmah , Christianus Annie , Wan Solahudin Wan Mohd Syazwan , Ismail Intan Safinar , Low Chen‐Fei 
Published: March 2024

AbstractVibrio alginolyticus is the causative agent of vibriosis, a common bacterial infection in grouper aquaculture that is associated with the development of haemorrhagic and non‐haemorrhagic ulcerations on the fish. In the present study, comparative proteome analysis was performed on serum samples from Vibrio‐resistant and Vibrio‐susceptible grouper. Samples were analysed using high‐throughput LC‐MS/MS and identified 2770 unique peptides that corresponded to 344 proteins. Subsequent analysis identified 21 proteins that were significantly up‐regulated in the resistant group compared to the control and the susceptible groups. Those proteins are associated with immunostimulatory effects, signalling and binding cascade, metabolism, and maintaining tissue integrity and physiological condition. Besides, potential protein biomarkers related to the immune system were identified, which could be associated with the disease‐resistant phenotype. These data provide insights into the underlying immune mechanism of hybrid groupers upon Vibrio sp. infection.
Review of quorum‐quenching probiotics: A promising non‐antibiotic‐based strategy for sustainable aquaculture
Authors: Lubis Anisa Rilla , Sumon Md Afsar Ahmed , Dinh‐Hung Nguyen , Dhar Arun K. , Delamare‐Deboutteville Jérôme , Kim Do‐Hyung , Shinn Andrew P. , Kanjanasopa Duangkhaetita , Permpoonpattana Patima , Doan Hien Van , Linh Nguyen Vu , Brown Christopher L. 
Published: March 2024

AbstractThe emergence of antibiotic‐resistant bacteria (ARBs) and genes (ARGs) in aquaculture underscores the urgent need for alternative veterinary strategies to combat antimicrobial resistance (AMR). These measures are vital to reduce the likelihood of entering a post‐antibiotic era. Identifying environmentally friendly biotechnological solutions to prevent and treat bacterial diseases is crucial for the sustainability of aquaculture and for minimizing the use of antimicrobials, especially antibiotics. The development of probiotics with quorum‐quenching (QQ) capabilities presents a promising non‐antibiotic strategy for sustainable aquaculture. Recent research has demonstrated the effectiveness of QQ probiotics (QQPs) against a range of significant fish pathogens in aquaculture. QQ disrupts microbial communication (quorum sensing, QS) by inhibiting the production, replication, and detection of signalling molecules, thereby reducing bacterial virulence factors. With their targeted anti‐virulence approach, QQPs have substantial promise as a potential alternative to antibiotics. The application of QQPs in aquaculture, however, is still in its early stages and requires additional research. Key challenges include determining the optimal dosage and treatment regimens, understanding the long‐term effects, and integrating QQPs with other disease control methods in diverse aquaculture systems. This review scrutinizes the current literature on antibiotic usage, AMR prevalence in aquaculture, QQ mechanisms and the application of QQPs as a sustainable alternative to antibiotics.
The Interaction between Credit Constraints and Uncertainty Shocks
Authors: CHATTERJEE PRATITI , GUNAWAN DAVID , KOHN ROBERT 
Published: March 2024

AbstractThis paper proposes a novel link between credit markets and uncertainty shocks. We introduce a role for credit uncertainty via collateral constraints in an otherwise standard real business cycle (RBC) model and show that an increase in credit uncertainty triggers a precautionary response that interacts with the collateral constraint to generate a simultaneous decline in output, consumption, investment, real wages, and hours; a feature that previous work on uncertainty shocks without credit constraints is unable to produce in a flexible‐price environment. We also empirically test the theoretical predictions and show that an unforeseen increase in credit uncertainty generates a simultaneous decline in a broad measure of real activity in recessions.
Inflation—Who Cares? Monetary Policy in Times of Low Attention
Authors: PFÄUTI OLIVER 
Published: March 2024

AbstractI propose an approach to quantify attention to inflation and show that attention declined after the Great Inflation period. This decline in attention has important implications for monetary policy as it renders managing inflation expectations more difficult and can lead to inflation‐attention traps: prolonged periods of a binding lower bound and low inflation due to slowly adjusting inflation expectations. As attention declines, the optimal policy response is to increase the inflation target. The lower bound fundamentally changes the normative implications of declining attention: lower attention raises welfare absent the lower‐bound constraint, whereas it decreases welfare when accounting for the lower bound.