bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphometric analysis of adrenal gland in people living with human immunodeficiency virus
Authors: Kabakcı Ayşe Gül , Kuşcu Ferit , Pişkin Ferhat Can , Taşova Yeşim , Bozkır Memduha Gülhal 
Published: March 2024

Purpose: We aimed to evaluate the effect of Human Immunodeficiency Virus (HIV) infection on adrenal gland morphometry according to age, gender, body weight, survival status and CD4/CD8 parameters.
Materials and Methods: In this study, the CT archives (130 men and 30 women) of 160 people living with HIV infection who had imaging for any reason between 2008 and 2020 were scanned. Ages, years of follow-up, body weights, heights, CD4 and CD8 values of people with human immunodeficiency virus were obtained simultaneously with the CT examinations of the people. Anatomical measurements, adrenal gland shapes, length, corpus thickness, medial thickness, lateral thickness, distance to next anatomical structures (esophagus, vertebral column, vena cava inferior, aorta abdominalis and diaphragm) were evaluated.
Results: In our study, the average age was 40.29±13.19 (male: 39.78±12.50, female: 42.53±15.88), body weight and height were respectively 67.04±18.10 kg 157.92±6.21 cm in women and 77.06±12.93 kg, 171.67±8.97 cm in men, living with HIV infection were included. As anatomical measurements, the length, corpus thickness, medial crus thickness, lateral crus thickness, distance to the esophagus, columna vertebralis, vena cava inferior, aorta abdominalis and diaphragm of the adrenal gland were found respectively on the right; 4.77±1.70 cm, 3.59±1.23 mm, 2.76±0.83 mm, 2.79±0.87 mm, 3.21±1.21 cm, 1.45±0.85 cm, 0.92±0.57 cm, 2.41±0.65 cm, 1.57±0.84 cm and on the left; 5.78±2.8 cm, 3.77±1.43 mm, 3.38±1.17 mm, 2.92±1.06 mm, 3.10±1.26 cm, 2.11±0.7 cm, 4.10±0.83 cm, 0.90±0.45 cm, 1.21±0.73 cm. The most common adrenal gland type was recorded as Y. Additionally, the mean values of CD4 and CD8 were found to be 322.66±309.35 and 1024.48±930.15, respectively.
Conclusion: Some anatomical measurements of the adrenal gland of people living with HIV can be affected by age, gender, body weight, survival status and CD4/CD8 parameters.
Machine learning-based analysis of MRI radiomics in the discrimination of classical and non-classical polycystic over syndrome
Authors: Zengin Fıstıkçıoğlu Neriman , Rona Günay , Serel Tekin Ahmet , Arifoğlu Meral , Düzkalır Hanife Gülden , Evrimler Şehnaz , Özçelik Serhat , Aydın Kadriye 
Published: March 2024

Purpose: The aim of this study is to investigate the value of radiomics analysis on T2-weighted Magnetic Resonance imaging (MRI) images in differentiating classical and non-classical polycystic ovary syndrome (PCOS).
Materials and Methods: A total of 202 ovaries from 101 PCOS patients (mean age of 23±4 years) who underwent pelvic MRI between 2014 and 2022, were included in the study. Of the patients, 53 (52.5%) were phenotype A, 12 (11.9%) were phenotype B, 25 were phenotype C (25.1%), and 11 were phenotype D (10.9%). 130 (64.4%) of the ovaries were classical PCOS, 72 (35.6%) were non-classical PCOS. The ovaries were manually segmented in all axial sections using the 3D Slicer program. A total of 851 features were extracted. Python 2.3, Pycaret library was used for machine learning (ML) analysis. Datasets were randomly divided into train (70 %, 141) and test (30 %, 61) datasets. The performances of ML algorithms were compared with AUC, accuracy, recall, precision and F1 scores.
Results: Accuracy and AUC values in the training set ranged from 57%-73% and 0.50-0.73, respectively. The two best ML algorithms were Random Forest (rf) (AUC:0.73, accuracy:73%) and Gradient Boosting Classifier (gbc) (AUC:0.71, accuracy:70%). AUC, accuracy, recall and precision values and F1 score of the blend model obtained from these two models were 0.70, 73 %, 56 %, 66%, 58%, respectively.
Conclusion: Radiomic features obtained from T2W MRI are successful in distinguishing between classical and non-classical PCOS.
Genotype-phenotype correlation and mutation spectrum of HBB gene in the Hatay province of Turkey
Authors: Kaçmaz Murat , Aşıkovalı Semih 
Published: March 2024

Purpose: Thalassemia carriage and hemoglobinopathies are quite common disorders in Turkey, especially in the Çukurova region, including Hatay province. Due to the high case population and genetic diversity in our region, this study aimed to investigate the genotype-phenotype correlation in the HBB gene.
Materials and Methods: The data of patients who applied to Hatay Mustafa Kemal University Medical Genetics or Hematology Clinic between January 2010 and November 2022 were evaluated retrospectively.
Results: A total of 40 (100%) cases, comprising 25 (62.5%) homozygous and 15 (37.5%) compound heterozygous genotypes, were included in the study based on the mutation profiles in the HBB gene. In the analysis of the cases, it was seen that there were 17 different variants and 22 distinct genotypes. The three most common variants identified in this study were IVS-I-6 (T>C), IVS-I-1 (G>A), and IVS-II-848 (C>A). Of the cases with homozygous genotypes, 13 (52%) had the IVS-I-6 (T>C) variant. The most frequent genotypes observed in cases with compound heterozygous genotype were IVS-I-6 (T>C)/IVS-I-110 (G>A), IVS-I-6 (T>C)/Hb Knossos, and IVS-I-110 (G>A)/-101 C>T, each in 2 (13%) cases.
Conclusion: This study provides information on the phenotypic characteristics of very rare genotypes. We think that this information will be very beneficial, especially for clinicians interested in prenatal diagnosis, preimplantation genetic diagnosis, and postnatal genetic counseling.
CAPE ameliorates vascular damage caused by sepsis
Authors: Çimen Leyla , Çetin Aysun , Elmalı Ferhan 
Published: March 2024

parameters of vascular and oxidative damage caused by sepsis and to evaluated the effects of caffeic acid phenethyl ester (CAPE) on these damages.
Materials and Methods: Wistar-Albino male rats were used for this study. Rats were divided into 4 groups (n = 10). Group 1 animals were intraperitoneally (i.p) injected with sterile saline (Control Group). Group 2 animals were i.p injected with lipopolysaccharide (LPS), 20 mg / kg-weight dose (Sepsis Group). Group 3 animals were i.p injected with lipopolysaccharide, 20 mg / kg-weight dose. Immediately after LPS injection, CAPE was i.p injected at single dose, 10 µmol / kg-body weight (Treatment Group). A single dose of CAPE, 10 µmol / kg-body weight / day, was injected i.p to Group 4 animals for 5 days. After 5th day CAPE injection, a single dose of LPS 20 mg / kg-weight was injected (Protective Group). At the 6th hour after the injections applied to all groups, blood sample were taken intracardiac and their serum were separated for the studies. Homocysteine (Hcy), asymmetric dimethyl arginine (ADMA), endothelin-1 (ET-1) and vascular cellular adhesion molecule-1 (VCAM-1) were measured by enzyme-linked immunosorbent assay (ELISA). In addition, the protective and therapeutic effects of CAPE on these parameters was investigated.
Results: Control group Hcy, ADMA, ET-1 and VCAM-1 levels were found to be 4.987 ± 0.096 µmol/l, 0.803 ± 0.020 nmol/ml, 21.123 ± 2.575 ng/l, 3.155 ± 0.078 ng/ml, respectively. Sepsis group Hcy, ADMA, ET-1 and VCAM-1 levels were found to be 8.975 ± 0.160 µmol/l, 3.953 ± 0.678 nmol/ml, 52.446 ± 2.546 ng/l, 10.783 ± 1.068 ng/ml, respectively. Treatment group Hcy, ADMA, ET-1 and VCAM-1 levels were found to be 5.286 ± 0.037 µmol/l, 1.304 ± 0.040 nmol/ml, 27.995 ± 1.299 ng/l, 3.72 ± 0.073 ng/ml, respectively. Protective group Hcy, ADMA, ET-1 and VCAM-1 levels were found to be 5.401 ± 0.042 µmol/l, 1.431 ± 0.056 nmol/ml, 32.708 ± 1.326 ng/l, 4.058 ± 0.069 ng/ml, respectively. It was observed that the Hcy, ADMA, ET-1 and VCAM-1 levels of the sepsis group increased significantly compared to the control group (p0.05). It was observed that CAPE treatment significantly decreased these parameters levels. However, the use of CAPE as a protective was not as effective as its treatment effect.
Conclusion: Our results demonstrated that sepsis resulted in increase Hcy, ADMA, ET-1, VCAM-1 levels. All these changes indicate that sepsis-mediated vascular damage is increased. Our results demonstrated that CAPE is more effective in preventing sepsis-mediated damages when given as a treatment.
Effect of vitamin D in experimental varicocele model in rats
Authors: Ağtürk Gökhan , Tümer Cemil , Tutuk Okan , Doğan Hatice , Özcan Oğuzhan , Özgür Tümay , Gülbol Duran Gülay , Temiz Muhyittin 
Published: March 2024

Purpose: Varicocele is a pathological condition that affects approximately 20% of adult men, causing infertility and sperm deterioration. The aim of our study was to investigate the efficacy of vitamin D (Vit. D) in the pathophysiology of varicocele. We performed biochemical, gene expression analyses and histopathological to evaluate the efficacy of vitamin D in the experimental varicocele model.
Materials and Methods: In the study, 30 adult male Wistar Albino rats were used. The rats were divided into 3 groups equally as control group, experimental group (varicocele), treatment group (varicocele + D vit.). The treatment group received 500 IU/kg D vit. intramuscularly.
Results: Histopathological, TRPM2-8 gene expression and biochemical analyses were performed on testicular and blood samples collected at the end of the experiment. The experimental group showed a deterioration in tubular structure, a decrease in total antioxidant levels and an increase in total oxidant levels. The treatment group, on the other hand, showed an increase in TAS, a decrease in TOS and a beneficial improvement in tubular structure disorders. Analysis of gene expression levels showed that TRPM2-8 expression levels were significantly increased in the varicocele group and decreased in the treatment group.
Conclusion: In the varicocele model, the use of vitamin D had a significant effect on TRPM2-8 gene level, pathological seminiferous tubules and biochemical values. Further studies are needed to determine the clinical application of vitamin D in varicocele disease.
In silico investigation of potential COVID-19-associated microRNA signatures
Authors: Asfa Seyedehsadaf , Ökmen Didem , Pavlopoulou Athanasia 
Published: March 2024

Purpose: The global pandemic COVID-19, caused by the coronavirus SARS-CoV-2, is persistent despite the increasing vaccination rates, with new cases being reported per week. MicroRNAs, that is, non-coding RNA species that regulate gene expression at the post-transcriptional level, play a pivotal role in the SARS-CoV-2 life cycle, pathophysiology and host’s anticoronaviral responses. The objective of this study was the in silico discovery of functionally associated miRNAs that likely co-regulate COVID-19-related genes
Materials and Methods: In the present study, an integrative bioinformatics approach was employed, including database searching, gene set enrichment analysis, network-based and microRNA target prediction methods, towards the discovery of epigenetic determinants of COVID-19.
Results: An intricate microRNA-target gene network was constructed, and a set of 8 highly interacting microRNAs, that potentially co-target and co-regulate key COVID-19-related genes, was detected. These miRNAs and their corresponding genes are likely involved in the host’s response to SARS-CoV-2 infection.
Conclusion: The 8 functionally associated miRNAs could constitute a signature for COVID-19 diagnosis.
A clinico-pathological study of minor salivary gland tumors: experience of our institute
Authors: Sharma Sourabh , Kumar Vikesh , Thakkar Konark , Shandilya Yugam Prasad 
Published: March 2024

Background: Minor salivary glands are found throughout the entire upper aerodigestive tract. Minor salivary gland neoplasms represent less than 25% of intraoral salivary neoplasms. There are no uniform guidelines at present for treatment for minor salivary gland tumors as these are rare entities. The objective of the study was to evaluate the clinicopathological profile of minor salivary gland tumors and to evaluate follow up of patients after treatment.
Methods: The present study was a prospective observational study conducted on 11 patients of the Pacific Medical College and Hospital, Udaipur from 1 December 2020 to 31 December 2023 with complaints of intra-oral swelling with biopsy proven MSGT were included.
Results: Out of 11 patients, 7 were female and 4 were male. Highest incidence was found in patients in the 4th-5th decade of life. For most patients, painless swelling was the primary presentation. The most common site for minor salivary cancer was the hard palate 55%. The most common histological types were adenocystic carcinoma. In 10 cases complete surgical excision with clear margins was the preferred mode of treatment. In 1 palliative therapy was required. Among 11 patients, 2 required radiotherapy.
Conclusions: MSGT are rare, early diagnosed and resection with wide margins/neck dissections + SOS adjuvant therapy is key to treatment.
Antibiotic resistance pattern of Pseudomonas aeruginosa isolated from pus samples at tertiary care cancer hospital
Authors: Surve Kapil V. , Khaparkhuntikar Mukta N. , Siddiqui Nazneen S. , Iravane Jyoti A. 
Published: March 2024

Background: Pseudomonas aeruginosa is one of the most frequent opportunistic microorganisms causing infections in cancer patients. The aim of the study was to determine the antibiotic susceptibility of Pseudomonas aeruginosa and multidrug-resistant (MDR) isolates in cancer patients.
Methods: A retrospective study was conducted from January 2022 to December 2022 at Government Cancer Hospital, Aurangabad. A total of 143 pus samples were collected from both IPD and OPD patients. Pus samples were collected as per standard procedure and were inoculated on blood and MacConkey agar. The isolates were identified by standard protocols using biochemical tests. The antibiotic susceptibility pattern of each isolate was checked as per Clinical and Laboratory Standards Institute (CLSI) guidelines 2022 using Kirby-Bauer's disc diffusion method and VITEK 2 Automation. Data analysis was done by statical method with statistical software SPSS version 22.
Results: Out of 143 clinical samples 33 samples (23%) were positive for Pseudomonas aeruginosa growth. mean age of patients was 50 years old out of 33 isolates 12 (36%) isolates were multidrug-resistant, 11 (33%) isolates were extensively drug-resistant and 1 (3%) were pan-drug-resistant. The majority of isolates were responsive to polymyxin B 32 (96%) and colistin 32 (96%); However, the resistance to gentamycin, ceftazidime, and amikacin was higher, at 66%, 60%, and 57%, respectively.
Conclusions: This hospital-based retrospective study will help to implement better infection control strategies and improve the knowledge of antibiotic resistance patterns among clinicians. Thus, there is a need for an antibiotic stewardship program to monitor the resistant pattern in a tertiary care cancer hospital.
The prevalence of dry eye in patients with psoriasis attending a tertiary care hospital in western Maharashtra
Authors: Dange Kiran Jagannath , Rathore Kanchan Bala , Awake Praneet 
Published: March 2024

: Psoriasis affects 0.5–11.4% of adults. Psoriasis is caused by a complicated chain of immune cells and cytokines, containing tumour necrosis factors (TNF), interleukin (IL)-17, 22, and 23. Psoriasis causes systemic inflammation, which can cause arthritis, cardiovascular disease, and metabolic syndrome. Our study explores dry eye in Western Maharashtra's psoriasis patients at a tertiary care hospital. A tertiary care hospital outpatient dermatology and ophthalmology department psoriasis patients were included in a cross-sectional research. Patient ages spanned from 20 to 60 years. The anterior and posterior ocular segments were examined, and dry eye was assessed. OSDI, Schirmer's test, TBUT, and corneal and conjunctiva staining has been scored. The PASI score has been received. Degree of dry eye was assessed using Dews dry eye grading system. Dry eye was present in 63.1 percent of people. Cases included 24.4% with mild dryness in their eyes. Moderate dryness made up 46.3% of cases, and severe dryness made up 29.3% of cases. The PASI score and dry eye did not have a statistically significant connection (P=0.355). A PASI score of 10 to 25 indicated the most severe case of dry eye, followed by a score of 10 (29 eyes) and &#62;25. (23 eyes). A total of 81.5 percent of eyes had abnormal OSDI scores, 56.2 percent had abnormal TBUT scores, and 49.2 percent had abnormal Schirmer Test results. Dry eye in psoriasis patients requires dermatologist-ophthalmologist teamwork for comprehensive therapy. Psoriasis, especially in long-lasting cases, can lead to meibomian gland dysfunction.
Study of demographic profile, risk factor, clinical profile and microbiological profile of corneal ulcer
Authors: Gangadharappa Raghu , Siddaiah Chandraprabha , Appandairaju Anupriya 
Published: March 2024

: To study the demographic factors, risk factors, microbiological profile and clinical course of patients with corneal ulcer presenting to Minto Regional institute of ophthalmology Bangalore.: A total of 876 patients diagnosed with infective corneal ulcer from January 2018 to January 2020 were retrospectively reviewed and analyzed for demographic profile, risk factors, clinico-microbiological profile at Minto Regional institute of ophthalmology Bengaluru. Among the 876 patients, 596 (68.04%) were male and 280 (31.96%) were females. 613(69.97%) were in the age group of 51-60 years. 85.04% belonged to low socioeconomic class. History of injury from vegetative matter was the leading cause and was seen in 264(30.14%) patients. Among the 613 (69.98%) culture positive patients, 410 (46.81%) were positive for fungi, while 203 (23.17%) were positive for bacteria. 674(76.94%) out of 876 responded to conservative management alone, while 202 (23.06%) patients required therapeutic penetrating keratoplasty. Fungal corneal ulcers caused by Aspergillus were the most common type, followed by bacterial corneal ulcers due to Staphylococcus aureus. Incidence of fungal corneal ulcer is very high among agricultural and industrial workers. Lack of awareness and delayed treatment leads to corneal blindness. This emphasizes the need for awareness among at risk population and also shall guide clinicians in decision making regarding empirical treatment.
Tomographical study of optic strut location and its significance
Authors: Afroze M Khizer Hussain , Bhaskar Shreyas , Vishal A Ra , Raju V Tulsi , Vel P Shakthi 
Published: March 2024

To determine the attachment of optic strut relative to anterior clinoid process. To categorize optic strut into the sulcal, pre-sulcal, post-sulcal. To determine the association between laterality and optic strut attachment pattern. The study was conducted on 100 normal CT scans of Head and Para nasal sinus. Optic strut was classified as pre-sulcal, sulcal, post-sulcal, and asymmetric in relation to the prechiasmatic sulcus. Optic strut location was determined as anterior, middle and posterior with respect to anterior clinoid process. The optic strut was found to be anterior in 28% specimen, middle in 57% specimen and posterior in 15% specimen. The optic strut was pre-sulcal in 31% specimens, sulcal in 50%, post-sulcal in 16%. The above were observed bilaterally, and 3% were unilateral. Anatomical variations in the optic strut are significant in planning for anterior clinoidectomy and optic-canal decompression.
Investigating the influence of clinico-socio-demographic factors on ocular disorders in diabetes mellitus: A study from western Uttar Pradesh
Authors: Singh Manisha , Sinha Amrita , Chaturvedi Nandita , Srivastava Anurag , Tomar Utkarsh S 
Published: March 2024

The study aims to investigate the correlation between clinico-socio-demographic factors and ocular diseases in diabetic patients and assess the knowledge of patients with diabetes mellitus regarding diabetes-related ocular diseases.This cross-sectional study examined 120 diabetic patients referred from the Diabetic clinic. Clinico-socio-demographic data was analysed to understand ocular disease correlations and guide interventions. Anthropometric and medical history data were gathered using a self-developed questionnaire. Biochemical parameters, fasting, postprandial glucose and HbA1c levels were measured. Assessment of Awareness and experiences of diabetic ocular disease with a scoring system was done. Ocular exams (slit lamp, intraocular pressure, and fundus checks) were conducted by an ophthalmologist in the Ophthalmology OPD. The study found that the most prevalent ocular disease in diabetic patients was cataract (52.5%), followed by diabetic retinopathy (13.33%). Demographic factors showed significant associations with ocular diseases (p &#60; 0.05). The research identified a notable ocular disease prevalence among diabetes patients, with socioeconomic factors impacting treatment access and causing lasting eye damage. Awareness of diabetes and its complications was moderate, highlighting the need for enhanced education via diverse channels and healthcare facilities to enable early detection and improved outcomes.
The Influence of Islamic Social Reporting, Managerial Ownership and Capital Structure on Firm Value
Authors: Fitriyani Endah Nur 
Published: March 2024

Increasing competition in the business world makes companies strive to increase the prosperity of shareholders. one of which can be done to increase the prosperity of shareholders by increasing the value of the company. The purpose of this study is to determine the effect of Islamic social reporting, managerial ownership and capital structure on firm value. This study uses secondary data with a population of 30 companies registered on the Jakarta Islamic Index (JII) for the 2016-2020 period. Sampling was carried out using a purposive sampling technique with nine companies that met the criteria in this study. Based on the results of the t (partial) test that the Islamic social reporting variable has a significant positive effect on firm value, the managerial ownership variable has a significant positive effect on firm value, the capital structure variable has an insignificant positive effect on firm value. Keywords: islamic social reporting, managerial ownership, capital structure, firm value
Sharia Board Characteristics, Macroeconomic Factors, and Non-performing Financing of Indonesian Islamic banks
Authors: Mai Muhamad Umar , Kristianingsih Kristianingsih , Dahtiah Neneng 
Published: March 2024

This study examines the impact of Islamic board characteristics (SB) and macroeconomic factors on the Non-performing financing (NPF) of Islamic commercial banks (ICB). The sample of this study consisted of 14 ICBs in Indonesia from 2010 to 2021. In this study, data estimation used a one-step GMM System model. SB features such as SB Size and SB Woman were found to have a detrimental impact on NPF. GDP per capita, for example, negatively affects NPF, while inflation has a positive impact. However, this study could not show the impact of SB characteristics such as expertise and proximity of SB to NPF. The study also found that macroeconomic factors such as annual open unemployment and interest rates showed an insignificant negative influence on NFP. The findings of this study help regulators, investors, and management of Islamic banks better understand the impact of SB characteristics and macroeconomic factors on Non-performing financing (NPF) of Islamic banks, especially in the context of ICB in Indonesia. In addition, it is expected to inspire similar research in the future.