bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic susceptibility to prostate cancer in Taiwan: A genome‐wide association study
Authors: Bau Da‐Tian , Tsai Chia‐Wen , Chang Wen‐Shin , Yang Jai‐Sing , Liu Ting‐Yuan , Lu Hsing‐Fang , Wang Yu‐Wen , Tsai Fuu‐Jen 
Published: February 2024

AbstractWe conducted the first genome‐wide association study (GWAS) of prostate cancer (PCa) in Taiwan with 1844 cases and 80,709 controls. Thirteen independent single‐nucleotide polymorphisms (SNPs) reached genome‐wide significance (p < 5 × 10−8). Among these, three were distinct from previously identified loci: rs76072851 in CORO2B gene (15q23), odds ratio (OR) = 1.54, 95% confidence interval (CI), 1.36–1.76, p = 5.30 × 10−11; rs7837051, near two long noncoding RNA (lncRNA) genes, PRNCR1 and PCAT2 (8q24.21), OR = 1.41 (95% CI, 1.31–1.51), p = 8.77 × 10−21; and rs56339048, near an lncRNA gene, CASC8 (8q24.21), OR = 1.25 (95% CI, 1.16–1.35), p = 2.14 × 10−8. We refined the lead SNPs for two previously identified SNPs in Taiwanese: rs13255059 (near CASC8), p = 9.02 × 10−43, and rs1456315 (inside PRNCR1), p = 4.33 × 10−42. We confirmed 35 out of 49 GWAS‐identified East Asian PCa susceptibility SNPs. In addition, we identified two SNPs more specific to Taiwanese than East Asians: rs34295433 in LAMC1 (1q25.3) and rs6853490 in PDLIM5 (4q22.3). A weighted genetic risk score (GRS) was developed using the 40 validated SNPs and the area under the receiver‐operating characteristic curve for the GRS to predict PCa was 0.67 (95% CI, 0.63–0.71). These identified SNPs provide valuable insights into the molecular mechanisms of prostate carcinogenesis in Taiwan and underscore the significant role of genetic susceptibility in regional differences in PCa incidence.
GOLPH3 promotes tumor malignancy via inhibition of ferroptosis by upregulating SLC7A11 in cholangiocarcinoma
Authors: Yin Zheng , Liu Qi , Gao Ying , Wang Ruizhi , Qi Yunling , Wang Dong , Chen Lianzhou , Yin Xiaoyu , He Meifang , Li Wen 
Published: February 2024

AbstractGolgi phosphoprotein 3 (GOLPH3) has been reported as an oncogene in various tumors; however, the role and function of GOLPH3 and its relevant molecular mechanism in cholangiocarcinoma (CCA) are unclear. Herein, GOLPH3 expression in CCA tissues was observed to be significantly higher than that in paired adjacent noncancerous tissues. Clinicopathological analysis showed that GOLPH3 expression correlated positively with the tumor‐node‐metastasis stage. In addition, GOLPH3 expression correlated inversely with the overall survival of patients with CCA. Multivariate analysis showed that GOLPH3 was an independent prognostic factor for patients with CCA. Transcriptome analysis (RNA sequencing) of GOLPH3 knockdown cells showed that the expression levels of nine ferroptosis‐related genes were significantly changed, indicating the important biological function of GOLPH3 in ferroptosis in CCA cells. Furthermore, GOLPH3 knockdown could significantly promote Erastin‐induced ferroptosis in vitro and suppress tumor growth in vivo. Overexpression of GOLPH3 had the opposite effect on this phenotype. Further studies revealed that GOLPH3 knockdown was significantly associated with a decrease in cysteine content, an accumulation of the lipid peroxidation product malondialdehyde, an increase in reactive oxygen species, and sensitized CCA cells to Erastin‐induced ferroptosis. Moreover, changes in GOLPH3 expression were found to be consistent with the expression of light chain subunit solute carrier family 7 member 11 (SLC7A11). Thus, our study suggested that GOLPH3 functions as an oncoprotein in CCA and may suppress ferroptosis by facilitating SLC7A11 expression, suggesting that GOLPH3 could serve as a therapeutic target for CCA treatment.
Human Metabolism and Excretion of Kawakawa (Piper excelsum) Leaf Chemicals
Authors: Jayaprakash Ramya , Pook Chris , Ramzan Farha , Miles‐Chan Jennifer L. , Mithen Richard F. , Foster Meika 
Published: February 2024

ScopePiper excelsum (kawakawa) has a history of therapeutic use by Māori in Aotearoa New Zealand. It is currently widely consumed as a beverage and included as an ingredient in “functional” food product. Leaves contain compounds that are also found in a wide range of other spices, foods, and medicinal plants. This study investigates the human metabolism and excretion of kawakawa leaf chemicals.Methods and resultsSix healthy male volunteers in one study (Bioavailability of Kawakawa Tea metabolites in human volunteers [BOKA‐T]) and 30 volunteers (15 male and 15 female) in a second study (Impact of acute Kawakawa Tea ingestion on postprandial glucose metabolism in healthy human volunteers [TOAST]) consume a hot water infusion of dried kawakawa leaves (kawakawa tea [KT]). Untargeted Liquid Chromatography‐Tandem Mass spectrometry (LC‐MS/MS) analyses of urine samples from BOKA‐T identified 26 urinary metabolites that are significantly associated with KT consumption, confirmed by the analysis of samples from the independent TOAST study. Seven of the 26 metabolites are also detected in plasma. Thirteen of the 26 urinary compounds are provisionally identified as metabolites of specific compounds in KT, eight metabolites are identified as being derived from specific compounds in KT but without resolution of chemical structure, and five are of unknown origin.ConclusionsSeveral kawakawa compounds that are also widely found in other plants are bioavailable and are modified by phase 1 and 2 metabolism.
Structural Impact of Steroidal Glycoalkaloids: Barrier Integrity, Permeability, Metabolism, and Uptake in Intestinal Cells
Authors: Keuter Lucas , Wolbeck Alessa , Kasimir Matthias , Schürmann Lina , Behrens Matthias , Humpf Hans‐Ulrich 
Published: February 2024

ScopePotato tubers represent an essential food component all over the world and an important supplier of carbohydrates, fiber, and valuable proteins. However, besides their health promoting effects, potatoes contain α‐solanine and α‐chaconine, which are toxic steroidal glycoalkaloids (SGAs). Other solanaceous plants like eggplants and tomatoes produce SGAs as well, different in their chemical structure. This study aims to investigate toxic effects (cholinesterase inhibition, membrane, and barrier disruption), permeability, metabolism, and structure–activity relationships of SGAs.Methods and resultsα‐solanine, α‐chaconine, α‐solasonine, α‐solamargine, α‐tomatine, and their respective aglycones solanidine, solasodine, and tomatidine are analyzed using Ellman assay, cellular impedance spectroscopy, cell extraction, and Caco‐2 intestinal model. Additionally, metabolism is analyzed by HPLC‐MS techniques. The study observes dependencies of barrier disrupting potential and cellular uptake on the carbohydrate moiety of SGAs, while permeability and acetylcholinesterase (AChE) inhibition are dominated by the steroid backbone. SGAs show low permeabilities across Caco‐2 monolayers in subtoxic concentrations. In contrast, their respective aglycones reveal higher permeabilities, but are extensively metabolized.ConclusionBesides structure–activity relationships, this study provides new information on the overall effects of steroidal alkaloids on intestinal cells and closes a gap of knowledge for the metabolic pathway from oral uptake to final excretion.
Wideband miniaturized circularly polarized magnetoelectric dipole antenna array for millimeter‐wave applications
Authors: Meng Wenwen , Sun Yurong , Li Yuanyuan , Xu Juan 
Published: February 2024

AbstractA wideband and miniaturized circularly polarized (CP) magnetoelectric (ME) dipole antenna is proposed. Two pairs of rotationally symmetric patch structures replace the rectangular structure of the original linearly polarized ME dipole, generating a rotating electric field that results in CP‐radiated waves. And the magnetic dipole is modified to broaden the impedance bandwidth (IBW) and the axial ratio bandwidth (ARBW). Meanwhile，the simple l‐shaped feed structure makes the antenna more compact. To improve the antenna gain, a 2 × 2 CP ME‐dipole antenna array was designed, completed, and measured. The measured results show that the IBW of the antenna array is 41.5% (from 29.2 to 44.5 GHz), and 3 dB ARBW of 26.7% (from 34.7 to 45.4 GHz) has a peak gain of 13.7 dBic.
Primary bladder neck obstruction in men: The importance of urodynamic assessment and cystourethrography in measuring its severity
Authors: El Khoury Joey , Hermieu Nicolas , Chesnel Camille , Xylinas Evanguelos , Teng Maëlys , Ouzaid Idir , Hermieu Jean François , Amarenco Gérard , Hentzen Claire 
Published: February 2024

AbstractObjectivePrimary bladder neck obstruction (PBNO) is a condition primarily affecting young men, characterized by obstruction at the bladder neck, leading to lower urinary tract symptoms. The aim of this study was to identify a correlation between the severity of bladder neck opening impairment and urinary symptoms by means of urodynamic studies.Materials and MethodsA retrospective analysis was conducted in adult males diagnosed with PBNO at a university neurourology department between 2015 and 2022 who underwent voiding cystourethrography (VCUG) and pressure‐flow studies. The cohort was divided into two groups: absence of bladder neck opening on VCUG (Group A) and incomplete bladder neck opening (Group B).ResultsOut of the 82 patients with PBNO screened, 53 were included in the analysis. Nocturia was the only symptom more prevalent in Group A (65% in Group A vs. 30% in Group B,p = 0.02) but scores and subscores of the Urinary Symptom Profile questionnaire were not different between groups. In addition, the detrusor pressure at a maximum flow rate (PdetQmax), bladder outlet obstruction index (BOOI), and bladder contractility index (BCI) were higher in Group A than in Group B [PdetQmax (A = 93.7 ± 53.7 cmH2O vs. B = 65.7 ± 26.4 cmH2O;p = 0.01)–BOOI (A = 77 ± 58.3 vs. B = 48 ± 25.7;p = 0.03)–BCI (A = 136 ± 51.3 vs. B = 110 ± 41.7;p = 0.04)].ConclusionThis study demonstrates a significant association between the extent of bladder neck opening impairment observed on VCUG and obstruction and contraction urodynamic parameters, but no association with the severity of urinary symptoms. Future studies should evaluate the predictive value of treatment response and the occurrence of complications based on clinical and urodynamic parameters.
Effects of synthesis temperature on structures and properties of epoxidized soybean oil oligomers and starch‐based bioplastics
Authors: Yang Jianlei , Xu Shicai , Ran Xiuzhen , Ching Yern Chee , Sui Xiao , Wei Yunwei 
Published: February 2024

AbstractThe work investigated the synthesis of the oligomers with citric acid (CA) and epoxidized soybean oils (ESO) at various temperatures and the effects of the oligomers on the structures and properties of starch‐based bioplastics. CA was bonded effectively onto ESO via ring‐opening polymerization at 90°C as confirmed by the results of Fourier‐transform infrared spectroscopy, thermogravimetric analysis, and carboxylic group contents of CA‐ESO oligomers (CESO). The oligomers exhibited higher thermal stability than ESO. Regarding starch‐based bioplastics, CESO disrupted the hydrogen bonding interaction within starch molecules and formed the esterification reaction with starch. The bioplastics containing CESO exhibited remarkably higher structural homogeneity and opacity as the synthesis temperatures of CESO increased. However, the thermal properties of the bioplastics with various CESO reduced, which might be due to the decomposition of starch by CESO. The films containing CESO also exhibited lower tensile strength than the film with ESO, which might be related to the decomposition, crosslinking, and plasticization effects of CESO on starch. The bioplastics with CESO exhibited lower degradation due to a more intense interaction of CESO and starch. The study demonstrated the potential of CA as an interfacial linker of starch/ESO‐based bioplastics by adjusting the synthetic temperatures of CESO.
Multifunctionality of MWCNT and TiC hybrid filler silicone composite for energy harvesting and strain sensing
Authors: Manikkavel Amutheesan , Kumar Vineet , Park Sang‐Shin 
Published: February 2024

AbstractThe flexible silicone elastomer‐conductive composite was developed with enhanced energy harvesting and strain sensing. A hybrid nanofiller system with multi‐walled carbon nanotubes (MWCNTs) and titanium (IV) carbide (TiC) was used as reinforcing agents for the elastomer. The 4 MWCNT +5 TiC composite has 1.34 MPa tensile strength, 136.85% higher than unfilled silicone rubber (SR) matrix. The unfilled sample has a 1.558 MPa compressive modulus, while 4 MWCNT +5 TiC has 3.87 MPa. The machine and finger presses were utilized to test the energy harvesting of the composite. With greater cyclic stability, the 4 MWCNT +5 TiC sample performed exceptionally well in the machine press in the output voltage range of around 120 mV. Among the thumb presses, 2 MWCNT +5 TiC yielded the best results, with a voltage of about 100 mV. The 3 MWCNT +5 TiC sample produced 9044% more energy than the single filler 3 phr MWCNT sample from our previous work. Higher MWCNT content enhanced composite stiffness, making finger pressing harder and decreasing energy output. The strain sensing test on the 4 MWCNT +5 TiC composite showed high gauge factors (GF = 7.532 and 23.944) and good linearity (R2 = 0.909 and 0.939) over a strain range of Δε = 0%–14% and 14%–22%. Silicone composites' mechanical, energy harvesting, and strain sensing performance improved greatly with the MWCNT and TiC hybrid fillers. These composites could be used in self‐powered wearable electronics, machine or structural deformation monitoring, and human motion sensing.Highlights
A stretchable device was developed with improved energy harvesting and strain sensing.
Rubber composites were fabricated from MWCNTs, TiC hybrid fillers, and SR matrix.
The energy harvesting was 9044% higher for hybrid filler compared to MWCNT as the only filler.
Robust strain sensing properties with a gauge factor of 23.9, linearity of 0.91, and relaxation time of 0.1 s.
The final composites are useful for self‐powered wearable electronics, health monitoring, and human motion sensing.
Photon upconversion assisted ferroelectric photovoltaics: Device configuration with multifaceted influence in augmenting the photovoltaic response of BiFeO3 thin‐film solar cells
Authors: Wani Waseem Ahmad , Gupta Gaurav , Rath Shyama , Venkataraman Harihara , Ramaswamy Kannan 
Published: February 2024

AbstractThis work presents a novel paradigm for upconversion‐assisted ferroelectric photovoltaic devices. The system comprises a ferroelectric active layer (BiFeO3), an upconverter layer (Yb; Er‐doped ZnO), a conductive ITO‐coated glass substrate, and a reflective coating (Al) at the rear end of the glass substrate. The photovoltaic efficiency of the single‐layer BFO was found to be 0.71%. With the prescribed device model, the total solar efficiency of BiFeO3 improved significantly and touched solar conversion efficiency of 2.21%. This model's projection widens the future perspectives of device performance in emerging photovoltaic technology, mainly perovskite‐based solar cells.
Impulse oscillometry assessment of respiratory function in pediatric patients with a history of COVID‐19
Authors: Mercan Adnan , Beşe Simge Atar , Köksal Zeynep Güleç , Kara Soner Sertan , Uysal Pınar , Erge Duygu 
Published: February 2024

AbstractObjectiveWhile coronavirus disease 2019 (COVID‐19) is generally considered to exhibit a less severe clinical course in children than in adults, studies have demonstrated that respiratory symptoms can endure for more than 3 months following infection in at least one‐third of pediatric cases. The present study evaluates the respiratory functions of children aged 3–15 years within 3–6 months of their recovery from COVID‐19 using impulse oscillometry (IOS) and compares them with the values of healthy children.MethodsIncluded in this prospective cross‐sectional study were 63 patients (patient group) aged 3–15 years who contracted COVID‐19 between December 2021 and May 2022, as well as 57 healthy children as a control group, matched for age and sex. The demographic, clinical, and laboratory data of the patients were recorded, and respiratory function was assessed based on airway resistance (zR5, zR20, R5–20) and reactance (zX5, zX20, reactance area [AX], resonant frequency [Fres]) using an IOS device.ResultsThere were no significant differences in the age, weight, height, and body weight z score values of the two groups (p > .05). While the zR5 and R5–20 levels of the patient group were higher (p = .008 and p < .001, respectively) than those of the controls, the zR20, AX, and Fres values did not differ significantly between the groups (p > .05). The parameters indicating the reactance, including zX5 and zX20, were significantly lower in the patient group than in the control group (p = .028 and p < .001, respectively).ConclusionTotal and peripheral airway resistances were found to be elevated in children who had recovered from COVID‐19 in the preceding 3–6 months.
The effect of Aceria litchii (Keifer) infestation on the surface properties of litchi leaf hosts
Authors: Song Qingkui , Zheng Jianyu , Chen Shengde , Lan Yubin , Li Haifeng , Zeng Liling , Yue Xuejun 
Published: February 2024

AbstractsBACKGROUNDThe wettability of target crop surfaces affects pesticide wetting and deposition. The structure and properties of the leaf surface of litchi leaves undergo severe changes after infestation by Aceria litchii (Keifer). The objective of this study was to systematically investigate the surface texture and wettability of litchi leaves infested.RESULTSFirstly, the investigation focused on the surface structure and physicochemical properties of litchi leaves infested with Aceria litchii. Subsequently, different levels of Contact Angle (CA) were measured individually on the infested litchi leaves. Lastly, Surface Free Energy (SFE) and its polar and dispersive components were calculated using the Owens‐Wendt‐Rabel‐Kaelble (OWRK) method. The outcomes revealed distinctive 3D surface structures of the erineum at various stages of mycorrhizal growth. At stage NO. 1, the height of the fungus displayed a peaked appearance, with the skewness value indicating a surface characterized by more crests. In contrast, at stages NO. 2 and NO. 3, the surface appeared relatively flat. Furthermore, post‐infestation of litchi leaves, the CA of droplets on the abaxial surface of diseased leaves exhibited an increase, while the SFE value on the abaxial surface of leaves decreased significantly, in contrast to the abaxial surface of healthy leaves.CONCLUSIONThe infestation behavior of Aceria litchii changed the surface structure and chemistry of litchi leaves, which directly affected the CA value of foliar liquids and the SFE value of leaves, changing the surface wettability of litchi leaves from hydrophobic to superhydrophobic. This study provides useful information for improving the wetting and deposition behavior of liquid droplets on the surface of infested leaves. © 2024 Society of Chemical Industry.
Effect of proanthocyanidins on blood lipids: A systematic review and meta‐analysis
Authors: Wang Peng , Liu Xue Lian , Jiang Zong Zhe , Long Yang , Gao Chen Lin , Huang Wei , Tan Xiao Zhen , Ma Xiu Mei , Xu Yong 
Published: February 2024

AbstractProanthocyanidins (PCs) are natural antioxidant polyphenols and their effect on the regulation of blood lipids is still controversial. This study was conducted to evaluate the effect of PCs on lipid metabolism. We searched PubMed, Embase, Web of Science, Chinese biomedical literature service system, China National Knowledge Internet, and Wanfang Data with no time restriction until March 18, 2022, using various forms of “proanthocyanidins” and “blood lipid” search terms. Randomized controlled trials investigating the relationship between PCs and lipid metabolism were included. The standard system of Cochrane Collaboration was used to assess the quality of studies. We standardized mean differences (SMDs) with 95% confidence interval (CI) using the random‐effects model, Cohen approach. Seventeen studies (17 trials, N = 1138) fulfilled the eligibility criteria. PCs significantly reduced triglyceride, and increased recombinant apolipoprotein A1. Subgroup analysis showed a significant reduction in triglycerides in older adults (≥60 years) and total cholesterol for participants who were not overweight or obese (body mass index <24). An intervention duration of greater than 8 weeks reduced triglyceride and low‐density lipoprotein cholesterol levels but increased high‐density lipoprotein cholesterol. Different doses of PCs could regulate triglycerides, high‐density lipoprotein cholesterol and total cholesterol. PCs have beneficial effects on circulating lipids and may represent a new approach for treating or preventing lipid metabolism disorders. However, more high‐quality studies are needed to confirm these results.
A sustainable trajectory for the 2030 Agenda: Targeting historical lock‐ins to accelerate progress on all SDGs
Authors: Carlsen Henrik , Weitz Nina , Petrova Kristina , Kemp‐Benedict Eric 
Published: February 2024

AbstractThe 2030 Agenda states that the 17 sustainable development goals (SDGs) make parts of an indivisible whole, and research on SDG implementation highlights how managing goal interactions—synergies and trade‐offs—is key for implementation to be successful. Here, we present an empirically based and transparent method for developing “consistent scenarios” that identifies which SDGs will be unattainable if historical patterns of interaction between SDGs are maintained. Using historical data on SDG indicators and correlation analysis together with cross‐impact balance analysis, we identify such scenarios for a set of high‐ to low‐income countries. Finding no consistent scenario where progress can be made on all 17 SDGs for any of the countries, our findings demonstrate the importance of policies that target interactions and resolve trade‐offs rather than individual goals to unlock a sustainable future trajectory. This reflects what was novel about the SDGs as a framework for global development; that the goals are indivisible and achieving them all require systemic changes that alter how social and economic processes interact with the environment.
The Use of NiFe2O4 and CoFe2O4 Nanoparticles Produced by Green Synthesis as Electrode Material for Supercapacitors
Authors: Baytar Orhan , Ekinci Arzu , Şahin Ömer , Akdag Abdurrahman 
Published: February 2024

AbstractIn this report, for the first time, we have applied green synthesized NiFe2O4 and CoFe2O4 nanoparticles as electrode materials for supercapacitors (SCs). Bean pods extracts were used for the green synthesis of NiFe2O4 and CoFe2O4 nanoparticles. The structure and morphology of the samples were characterized by fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), energy dispersive X‐ray (EDX), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). From XRD analysis, it was determined that NiFe2O4 and CoFe2O4 nanoparticles had a crystalline structure. EDX analysis confirms the presence of carbon and the stoichiometries of NiFe2O4 and CoFe2O4. In TEM analyses, it was determined that the sizes of nanoparticles varied in the range of 5–20 nm. The FTIR spectra supported the presence of Fe−O, Ni−O, and Co−O bonds. Electrochemical measurements of active materials were performed using cyclic voltammetry, galvanostatic charge‐discharge, and electrochemical impedance spectroscopy techniques in a 1 M H2SO4 solution. It was determined that the specific capacitance value of NiFe2O4 (129 F/g) was higher than that of CoFe2O4 (106 F/g). The cyclic stability of CoFe2O4 and NiFe2O4 was found to be 59 and 106 % retention at the end of 10000 cycles, respectively. The specific capacitance value and very good cyclic stability of NiFe2O4 showed that it is a good active substance that can be used in supercapacitor applications.