bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hematopoietic Stem Cell Transplantation in Hemophagocytic Lymphohistiocytosis: A Single-Center Report of 48 Patients
Authors: Ouachée-Chardin Marie , Elie Caroline , de Saint Basile Geneviève , Le Deist Françoise , Mahlaoui Nizar , Picard Capucine , Neven Bénédicte , Casanova Jean-Laurent , Tardieu Marc , Cavazzana-Calvo Marina , Blanche Stéphane , Fischer Alain 
Published: March 2006

OBJECTIVES. Familial hemophagocytic lymphohistiocytosis (FHLH) is a genetically determined disorder characterized by the early onset of fever, hepatosplenomegaly, central nervous system disease, thrombocytopenia, coagulation disorders, and hemophagocytosis. It is caused by genetic defects that impair T cell–mediated and natural cytotoxicity. Chemotherapy- or immunotherapy-based treatments can achieve remission. Hematopoietic stem cell transplantation (HSCT), however, is the only curative option, but optimal modalities and long-term outcome are not yet well known.
METHODS. We retrospectively analyzed the outcome of HSCT that was performed in 48 consecutive patients who had FHLH and were treated in a single center between 1982 and 2004.
RESULTS. The overall survival was 58.5% with a median follow-up of 5.8 years and extending to 20 years. A combination of active disease and haploidentical HSCT had a poor prognosis because in this situation, HLH disease is more frequently associated with graft failure. Twelve patients received 2 transplants because of graft failure (n = 7) or secondary graft loss that led to HLH relapse (n = 5). Transplant-related toxicity essentially consisted in veno-occlusive disease, which occurred in 28% of transplants and was associated with young age, haploidentical transplantation, and the use of antithymocyte globulin (ATG) in the conditioning regimen. A sustained remission was achieved in all patients with a donor chimerism ≥20% of leukocytes. Long-term sequelae were limited, because only 2 (7%) of 28 patients experienced a mild neurologic disorder.
CONCLUSIONS. This survey demonstrates the long-term efficacy of HSCT as a cure of FHLH. HSCT preserves quality of life. It shows that HSCT should be performed as early as a complete remission has been achieved. Additional studies are required to improve the procedure and reduce its toxic effects.
Jet grouting with the superjet-midi method
Authors: Fang Y. S. , Kao C. C. , Chou J. , Chain K. F. , Wang D. R. , Lin C. T. 
Published: March 2006

This paper introduces the superjet-midi (SJM) method, which has been developed to improve the efficiency of jet grouting. The diameters of soilcrete columns constructed with the new method are relatively large (2·4–3·5 m). Advantages and limitations of the SJM method are summarised. To examine the quality of construction, cylindrical SJM specimens were recovered at the site, and field and laboratory tests were conducted. It is found that the jet-sounding technique is a simple and economical measure to estimate the effective diameter of soilcrete columns. The rock quality designation of specimens varies from 79% to 97%, which indicates that the quality of the soilcrete is good. The uniaxial compressive strength qu of jumbo-jet special grout and SJM specimens are similar. The modulus of elasticity Et50 varies from 350 to 1990 MN/m2. These data are in good agreement with the range E50 = 100qu –300qu suggested by the JSG Association. Axial failure strains of SJM soilcrete are relatively close to the failure strains for concrete rather than those for soil. Cet exposé présente la méthode superjet-midi (SJM) qui a é té développée afin d'améliorer l'efficacité de l'injection de ciment. Les diamètres des colonnes de sol bétonné construites grâce à la nouvelle méthode sont relativement importants (2·4–3·5 m). Nous résumons les avantages et les limitations de la méthode SJM. Pour examiner la qualité de la construction, des spécimens SJM cylindriques ont é té récupérés sur le site et des essais sur le terrain et en laboratoire ont é té menés. Nous avons trouvé que la technique de sondage sous injection est un moyen simple et é conomique pour é valuer le diamètre effectif des colonnes de sol bétonné. La dé signation de qualité rocheuse des spécimens varie de 79% à 97%, ce qui indique que la qualité du sol bétonné est bonne. Les forces compressives uniaxiales qu des spécimens JSG et SJM sont similaires. Le module d'élasticité Et50 varie de 350 à 1990 MN/m2. Ces données concordent avec la gamme E50 100qu –300qu suggérée par l'Association JSG. Les déformations de rupture axiale du sol bétonné SJM sont relativement plus proches des déformations de rupture du béton que de celles du sol.
Predicting Flare in Patients With Rheumatoid Arthritis in Biologic Induced Remission, on Tapering, and on Stable Therapy
Authors: Gul Hanna , Di Matteo Andrea , Anioke Innocent , Shuweidhi Farag , Mankia Kulveer , Ponchel Frederique , Emery Paul 
Published: February 2024

ObjectiveThe tapering of biologic disease‐modifying antirheumatic drug (b‐DMARD) therapy for patients with rheumatoid arthritis (RA) in stable remission is frequently undertaken, but specific guidance on how to successfully taper is lacking. The objective of this study is to identify predictors of flare in patients in stable b‐DMARD–induced clinical remission, who did or did not follow structured b‐DMARD tapering.MethodsPatients with RA receiving b‐DMARD treatment who had achieved sustained remission according to a Disease Activity Score in 28 joints using the C‐reactive protein level (DAS28‐CRP) <2.6 for ≥6 months were offered tapering. Clinical, ultrasound (US) (total power Doppler [PD]/grayscale abnormalities), CD4+ T cell subsets, and patient‐reported outcomes (PROs) were collected at inclusion. The primary endpoint was the occurrence of flare (loss of DAS28‐CRP remission) over 12 months. Logistic regression analyses identified predictors of flare. Dichotomization into high/low‐risk groups was based on 80% specificity using the area under the receiving operator curve (AUROC).ResultsOf 63 patients choosing tapering, 23 (37%) flared compared with 12 of 60 (20%) on stable treatment (P = 0.043). All patients who flared regained remission upon reinstating treatment. In the tapering group, flare was associated with lower regulatory T cell (Treg) (P < 0.0001) and higher CRP levels (P < 0.0001), erythrocyte sedimentation rate (P < 0.035), and inflammation‐related cells (IRCs) (P = 0.054); stepwise modeling selected Tregs (odds ratio [OR] = 0.350, P = 0.004), IRCs (OR = 1.871, P = 0.007), and CRP level (OR = 1.577, P = 0.004) with 81.7% accuracy and AUROC = 0.890. In the continued therapy group, modeling retained the tender joint count, total PD, and visual analog scale pain score, with 82.1% accuracy and AUROC = 0.899. Most patients in the study were considered low risk of flare (80 of 123 patients [65%]). Only 5 of 37 (13.5%) of the low‐risk patients who tapered flared, which was notable compared with the continued therapy group (20% flare).ConclusionFlare on tapering b‐DMARDs was predicted by lower Tregs and elevated inflammation biomarkers (IRCs/CRP level); flare on continued b‐DMARDs was associated with raised pain parameters and US inflammation. Knowledge of these biomarkers should improve outcomes by targeted selection for tapering, and by increased monitoring of those on continued therapy predicted to flare.
Black Phosphorus Covalent Bonded by Metallic Antimony Toward High‐Energy Lithium‐Ion Capacitors
Authors: Ma Yibo , Wang Kai , Xu Yanan , Zhang Xudong , Peng Qifan , Guo Yang , Sun Xianzhong , Zhang Xiong , Wu Zhong‐Shuai , Ma Yanwei 
Published: February 2024

AbstractBlack phosphorus (BP) has been recognized as an alluring fast‐charging anode for batteries/supercapacitors due to its substantial theoretical capacity, propitious lithiation potential, and large interlayer spacing. Nonetheless, it is encumbered by challenges of low electronic conductivity, momentous volume expansion (≈300%), and pernicious shuttle effect induced by soluble polyphosphides. Here a BP heterostructure covalent bonded by metallic antimony (Sb) is showed, which can promote the reaction dynamics of BP and greatly ameliorate the cycling performance. Robust P─Sb covalent bonds are methodically engineered to regulate the Femi level, endowing enhanced electronic conductivity. The in situ generated Li7SbO6 ionic conductor in the P/Sb interface during the lithiation process ensures the fast Li+ transport. Furthermore, Sb offers strong anchoring and chemical adsorption capability on soluble lithium polyphosphides, preventing the shuttle issue. As a result, a lithium‐ion capacitor (LIC) full‐cell based on Sb@BP/C anode demonstrates a superior energy density of 174.3 W h kg−1 and a power density of 23.7 kW kg−1, as well as exceptional reversible capacity retention. This work provides insights into the regulation of reaction kinetics and chemical adsorption capability of BP, offering guidance for designing high‐capacity and stable BP‐based anodes.
Subsequent correlated changes in complement component 3 and amyloid beta oligomers in the blood of patients with Alzheimer's disease
Authors: Shim Kyu Hwan , Kim Danyeong , Kang Min Ju , Pyun Jung‐Min , Park Young Ho , Youn Young Chul , Park Kyung Won , Suk Kyoungho , Lee Ho‐Won , Gomes Bárbara Fernandes , Zetterberg Henrik , An Seong Soo A. , Kim SangYun ,   for the Alzheimer's Disease All Markers (ADAM) Research group
Published: February 2024

AbstractINTRODUCTIONAlzheimer's disease (AD) involves the complement cascade, with complement component 3 (C3) playing a key role. However, the relationship between C3 and amyloid beta (Aβ) in blood is limited.METHODSPlasma C3 and Aβ oligomerization tendency (AβOt) were measured in 35 AD patients and 62 healthy controls. Correlations with cerebrospinal fluid (CSF) biomarkers, cognitive impairment, and amyloid positron emission tomography (PET) were analyzed. Differences between biomarkers were compared in groups classified by concordances of biomarkers.RESULTSPlasma C3 and AβOt were elevated in AD patients and in CSF or amyloid PET–positive groups. Weak positive correlation was found between C3 and AβOt, while both had strong negative correlations with CSF Aβ42 and cognitive performance. Abnormalities were observed for AβOt and CSF Aβ42 followed by C3 changes.DISCUSSIONIncreased plasma C3 in AD are associated with amyloid pathology, possibly reflecting a defense response for Aβ clearance. Further studies on Aβ‐binding proteins will enhance understanding of Aβ mechanisms in blood.
U.S. dementia care spending by state: 2010–2019
Authors: Lastuka Amy , Breshock Michael R. , McHugh Theresa A. , Sogge William T. , Swart Vivianne , Dieleman Joseph L. 
Published: February 2024

AbstractINTRODUCTIONDementia is the fourth largest cause of death for individuals 70 years of age and older in the United States, and it is tremendously costly. Existing estimates of the indirect costs of dementia are dated and do not report on differences across the United States.METHODSWe used data from multiple surveys to create cost estimates and projections for informal dementia caregiving at the U.S. state level from 2010 through 2050.RESULTSIn 2019, the annual replacement cost of informal caregiving was $42,422 per prevalent case, and the forgone wage cost was $10,677 per prevalent case. In 2019, it would have cost $230 billion to hire home health aides to provide all this care. If past trends persist, this cost is expected to grow to $404 billion per year in 2050.DISCUSSIONThe cost of informal care varied substantially by state and is expected to grow through at least 2050.Highlights
In the United States in 2019, foregone wages due to informal dementia care was $58 billion.
Replacing informal dementia care with health aides would have cost $230 billion.
These costs vary dramatically by state, even when assessed per prevalent case.
These costs are expected to nearly double by 2050.
Air‐Promoted Light‐Driven Hydrogen Production from Bioethanol over Core/Shell Cr2O3@GaN Nanoarchitecture
Authors: Wang Zhouzhou , Chen Yiqing , Sheng Bowen , Li Jinglin , Yao Lin , Yu Ying , Song Jun , Yu Tianqi , Li Yixin , Pan Hu , Wang Ping , Wang Xinqiang , Zhu Lei , Zhou Baowen 
Published: February 2024

AbstractLight‐driven hydrogen production from biomass derivatives offers a path towards carbon neutrality. It is often however operated with the limitations of sluggish kinetics and severe coking. Herein, a disruptive air‐promoted strategy is explored for efficient and durable light‐driven hydrogen production from ethanol over a core/shell Cr2O3@GaN nanoarchitecture. The correlative computational and experimental investigations show ethanol is energetically favorable to be adsorbed on the Cr2O3@GaN interface, followed by dehydrogenation toward acetaldehyde and protons by photoexcited holes. The released protons are then consumed for H2 evolution by photogenerated electrons. Afterward, O2 can be evolved into active oxygen species and promote the deprotonation and C−C cleavage of the key C2 intermediate, thus significantly lowering the reaction energy barrier of hydrogen evolution and removing the carbon residual with inhibited overoxidation. Consequently, hydrogen is produced at a high rate of 76.9 mole H2 per gram Cr2O3@GaN per hour by only feeding ethanol, air, and light, leading to the achievement of a turnover number of 266,943,000 mole H2 per mole Cr2O3 over a long‐term operation of 180 hours. Notably, an unprecedented light‐to‐hydrogen efficiency of 17.6 % is achieved under concentrated light illumination. The simultaneous generation of aldehyde from ethanol dehydrogenation enables the process more economically promising.
Nucleophiles realizing the reduction of ZnO content for vulcanization accompanied by the improvement in thermo‐oxidative resistance for vulcanized isoprene rubbers
Authors: Xie Wei‐Lin , Hou Zhao‐Bo , Liu Gui‐Xiang , Liao Shuangquan , Luo Ming‐Chao 
Published: February 2024

AbstractAt present, vulcanization is an indispensable process in rubber industries and ZnO is an important ingredient in vulcanization reactions. However, ZnO is toxic to aquatic organisms and the use of ZnO is unfavorable to the sustainable development of rubber industry. The decrease of ZnO content without the reduction in properties of rubbers has been an open question in rubber industries. In this work, our group designs nucleophiles with an ability to open the ring of sulfur. With the decrease of ZnO content, the addition of nucleophiles maintains the ring‐opening capacity of sulfur. As a result, changes in several properties of rubbers such as tensile strength, tear strength, and crosslinking density are negligible with the reduction of ZnO content. Also, the thermo‐oxidative resistance of rubbers improves dramatically with the decrease of ZnO content and addition of nucleophiles. Through designing nucleophiles to reduce the content of ZnO, this work provides a strategy to develop sustainable rubber industries.
Hsa_circ_0001480 affects osteosarcoma progression by regulating the miR‐363‐3p/IBSP pathway
Authors: Bi Guijuan , Zhang Li 
Published: February 2024

AbstractOsteosarcoma (OS) is a malignant bone tumor that commonly affects young individuals. Circular RNAs (circRNAs) are associated with OS progression. In this study, we aimed to determine the role of hsa_circ_0001480 (circ_0001480) in OS development. OS cell invasion, viability, and colony numbers were assessed via transwell, cell counting kit‐8, and colony formation assays, respectively. Tumor growth in vivo was also assessed using an OS mouse model. Additionally, targeted associations among the integrin‐binding sialoprotein (IBSP), microRNA (miR)‐363‐3p, and circ_0001480 were evaluated via RNA immunoprecipitation and dual luciferase reporter assays, whereas their expression levels in OS cells and tissues were determined via quantitative reverse transcription‐polymerase chain reaction and western blotting. Loss of circ_0001480 or IBSP significantly inhibited the proliferation and invasion of OS cells, but this effect was reversed by miR‐363‐3p downregulation. Moreover, circ_0001480 knockdown inhibited neoplasm growth in vivo. circ_0001480 directly bound to miR‐363‐3p, which further modulated IBSP. Both circ_0001480 and IBSP levels were high, whereas miR‐363‐3p levels were low in OS cells. Furthermore, low miR‐363‐3p levels attenuated the suppressive effects of circ_0001480 silencing on the proliferation and invasion of OS cells; however, loss of IBSP partially reversed these effects. Overall, our findings revealed circ_0001480 an oncogenic circRNA stimulating OS progression by modulating the miR‐363‐3p/IBSP pathway, suggesting its potential for OS treatment.
Electron Transfer Kinetics at Single‐Layer Graphene/Ionic Liquid Interfaces
Authors: Liu Shuai , Pignol Guilhem , Lagrost Corinne , Mao Bingwei , Yan Jiawei , Hapiot Philippe 
Published: February 2024

AbstractElectron transfer kinetics at the single‐layer graphene/ionic liquids interfaces have been examined for different common imidazolium‐based ionic liquids and ferrocene derivatives. The heterogeneous kinetics are characterized by slow standard charge transfer rates and an unusual low variation of the rate with the applied potential corresponding to charge transfer coefficients lower than 0.1. This behavior is specific to the electrochemistry on a single‐layer graphene as we found that the oxidation of the same substituted ferrocenes in the same ionic liquids follows the classical behavior predicted by the Butler‐Volmer law.
Boosting overall saline water splitting by constructing a strain‐engineered high‐entropy electrocatalyst
Authors: Bao Ateer , Gu Yaohang , Zhang Yuxuan , Zhang Bowen , Wu Juncheng , Ni Bo , Zhang Xiaoyan , Pan Haijun , Qi Xiwei 
Published: February 2024

AbstractHigh‐entropy materials (HEMs), which are newly manufactured compounds that contain five or more metal cations, can be a platform with desired properties, including improved electrocatalytic performance owing to the inherent complexity. Here, a strain engineering methodology is proposed to design transition‐metal‐based HEM by Li manipulation (LiTM) with tunable lattice strain, thus tailoring the electronic structure and boosting electrocatalytic performance. As confirmed by the experiments and calculation results, tensile strain in the LiTM after Li manipulation can optimize the d‐band center and increase the electrical conductivity. Accordingly, the as‐prepared LiTM‐25 demonstrates optimized oxygen evolution reaction and hydrogen evolution reaction activity in alkaline saline water, requiring ultralow overpotentials of 265 and 42 mV at 10 mA cm−2, respectively. More strikingly, LiTM‐25 retains 94.6% activity after 80 h of a durability test when assembled as an anion‐exchange membrane water electrolyzer. Finally, in order to show the general efficacy of strain engineering, we incorporate Li into electrocatalysts with higher entropies as well.
Recent Progresses and Challenges in Upcycling of Plastics through Selective Catalytic Oxidation
Authors: Wang Kaili , Yuan Fan , Huang Lei 
Published: February 2024

AbstractChemical upcycling of plastics provides an important direction for solving the challenging issues of plastic pollution and mitigating the wastage of carbon resources. Among them, catalytic oxidative cracking of plastics to produce high–value chemicals, such as catalytic oxidation of polyethylene (PE) to produce fatty dicarboxylic acids, catalytic oxidation of polystyrene (PS) to produce benzoic acid, and catalytic oxidation of polyethylene terephthalate (PET) to produce terephthalic acid under mild conditions has attracted increasing attention, and some exciting progress has been made recently. In this article, we will review recent progresses on the catalytic oxidation upcycling of plastics and provide our understanding on the current challenges in catalytic oxidation upcycling of plastics.
Designing Low Toxic Deep Eutectic Solvents for the Green Recycle of Lithium‐Ion Batteries Cathodes
Authors: Li Yilin , Sun Mingjie , Cao Yanbo , Yu Keying , Fan Zixuan , Cao Yuanyuan 
Published: February 2024

AbstractThe Lithium‐ion battery (LIB) is one of the main energy storage equipment. Its cathode material contains Li, Co, and other valuable metals. Therefore, recycling spent LIBs can reduce environmental pollution and resource waste, which is significant for sustainable development. However, traditional metallurgical methods are not environmentally friendly, with high cost and environmental toxicity. Recently, the concept of green chemistry gives rise to environmental and efficient recycling technology, which promotes the transition of recycling solvents from organic solvents to green solvents represented by deep eutectic solvents (DESs). DESs are considered as ideal alternative solvents in extraction processes, attracting great attention due to their low cost, low toxicity, good biodegradability, and high extraction capacity. It is very important to develop the DESs system for LIBs recycling for sustainable development of energy and green economic development of recycling technology. In this work, the applications and research progress of DESs in LIBs recovery are reviewed, and the physicochemical properties such as viscosity, toxicity and regulatory properties are summarized and discussed. In particular, the toxicity data of DESs are collected and analyzed. Finally, the guidance and prospects for future research are put forward, aiming to explore more suitable DESs for recycling valuable metals in batteries.
Enhancing grid‐connected solar PV systems with a novel three‐phase hybrid multilevel inverter
Authors: Pushparaj Nirmal Kumar , Nattamai Balasubramanian Prakash 
Published: February 2024

SummaryThis paper presents a novel three‐phase hybrid multilevel inverter (TPHMLI) designed for grid‐connected solar photovoltaic (SPV) systems. The TPHMLI combines series‐connected bridge topologies of half and full circuits to generate 11 stages of line load voltages, reducing the need for DC sources. It also introduces an improved pulse width modulation (PWM) approach, addressing computational challenges and high‐frequency triggering issues. Practical validation in a laboratory setting demonstrates the MLI's functionality and effectiveness. Furthermore, the advanced MLI topology successfully addresses design issues in grid‐integrated SPV structures, including power quality, efficiency, and reliability. It excels in managing reactive power and fault obstructive capabilities. Extensive simulations using MATLAB/Simulink confirm its superior performance, making it a promising solution for power conditioning units in grid‐connected solar PV systems. This research contributes to clean and sustainable energy conversion technologies, enhancing power quality and cost‐effectiveness, with significant potential for practical applications in the renewable energy sector.