bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of ACE1 and ACE2 genetic polymorphisms on SARS-CoV-2 infection and severity of symptoms in different regions of Iraq
Authors: Khashan Bilal Ali , Thalij Karkaz Mohammed , Yaseen Ali Ameen 
Published: April 2024

This study was conducted in the laboratories of the Biology Department - College of Science - Tikrit University, the laboratories of the Food Science Department - College of Agriculture - University of Anbar, and the Public Health Laboratories - Anbar for the period from December 2021 AD until February 2022 AD, study involved taking samples from hospitalized COVID-19 patients of both sexes, after a confirmed positive PCR test result. As well as those lying in quarantine in three Iraqi governorates (the isolation unit in Karkh, Yarmouk and Kadhimiya hospitals, the Al-Shifa quarry hospital in Anbar, the public health laboratory in Anbar, and the quarantine hospital for thousands in Erbil), in addition to outpatient clinics. They were distributed by 30 patients and 20 healthy subjects from each governorate, with ages ranging from 18-80 years, randomly to men and women in order to determine the role of genetic polymorphisms in the ACE inhibitor gene in the study samples. The results of the genetic polymorphisms of ACE-1rs4646994, ACE-2rs2106809, and ACE-2rs4240157 showed that there were non-significant differences between the frequency of alleles and genotypes in the patient's group compared with the healthy group. The DD mutant genotype of ACE-1rs4646994 appeared in the patient's group in Baghdad and Anbar with a high percentage, while patients in Erbil showed the highest percentage of the heterozygous genotype ID compared to healthy subjects, with an OR= 0.922, OR= 2.750, and OR= 1.118, respectively, for the mutant allele D. Therefore, it is not considered a risk factor for the disease in Baghdad, in contrast to Anbar and Erbil. The polymorphism of ACE-2rs2106809, the homozygous genotype CC was dominant in patients in the aforementioned provinces and may not be considered a risk factor for the disease. The results of ACE-2rs4240157 gene polymorphism, the heterozygous CT genotype showed a high percentage in patients in Baghdad and, while in Anbar patients, the normal genotype TT appeared to be the highest percentage compared to healthy subjects. The C mutant allele in Baghdad, Anbar, and Erbil patients reached OR= 1.306, OR= 4.333, and OR= 9.00, respectively, so this allele is considered a risk factor for the disease. We can conclude from this study the role of each of the polymorphisms rs4646994 ACE-1 and rs4240157 ACE-2 in infection with COVID-19 and the severity of its symptoms according to the geographical region and race, in contrast to rs2106809 ACE-2, as it is possible to conduct clinical studies to demonstrate the role of genetic polymorphisms with Relationship to diseases depending on the region and race.
Synthesis and characterization of zinc-titanium oxide nanoparticles blended methylcellulose derived from Albizia tree as an antibacterial natural polymer composite
Authors: Hashim Ansam Adnan , Jamei Rashid 
Published: April 2024

This paper seeks to synthesize antibacterial green polymeric composites utilizing extracted cellulose, a natural polymer sourced from biomass. The cellulose was obtained from local agricultural waste. Subsequently, the polymeric composites were synthesized, incorporating blends of nano zinc oxide and nano titanium dioxide in varying proportions. All synthesized samples undergo comprehensive characterization and examination through a range of tests encompassing structural and thermal testes. Furthermore, the antibacterial activity of the samples was assessed using the disc diffusion method, enabling the identification of the most effective formulations. The ultimate selection of the optimal composite was based on the collective outcomes of all tests, facilitating its potential utilization across diverse applications. In conclusion, the Albizia tree demonstrates a notable potential for efficient cellulose extraction, making it a viable candidate for such purposes. The cellulose extracted from Albizia tree holds the capability to yield methylcellulose. The bacterial activity assessment of Nano materials highlighted a distinct efficacy in the case of the 75% Nano TiO2 and 25% Nano ZnO mixture. However, it is worth noting that an excessive increment in Nano ZnO content exhibited adverse effects. Thorough thermal analyses verified the thermal stability of methylcellulose.
Faktor-Faktor yang Berhubungan dengan Tekanan Darah Lansia di Kabupaten Klaten
Authors: Meilianingrum Chandra Nur , Khomsan Ali 
Published: April 2024

Hipertensi pada lansia menjadi hal yang umum terjadi. Tekanan darah yang tinggi dapat memengaruhi kesehatan lansia. Penelitian ini bertujuan menganalisis hubungan pola konsumsi makanan, status gizi, insomnia, dan tekanan darah pada lansia serta perbedaannya antara lansia laki-laki dan lansia perempuan berdasarkan variabel yang diteliti. Penelitian cross sectional study dilakukan terhadap 96 subjek lansia dengan rata-rata usia lansia laki-laki 69,6±5,7 dan lansia perempuan dengan usia 66,4±5,4 tahun. Pengambilan data dilakukan dengan pengukuran estimasi berat badan dan tinggi badan, tekanan darah, dan wawancara pola konsumsi makanan. Hasil penelitian menunjukkan bahwa lansia perempuan sebagian besar mengalami hipertensi tingkat II sebesar 41,7% sedangkan lansia laki-laki menglami hpertensi tingkat I (29,2%). Mayoritas lansia laik-laki dan perempuan memiliki status gizi yang nomal. Asupan konsumsi gula, natrium, dan lemak pada lansia cenderung normal. Adapun, tingkat kecukupan zat gizi makro dan mikro cenderung kurang dari angka kecukupan gizi. Hasil uji beda menunjukkan bahwa terdapat perbedaan yang signifikan antara kelompok laki-laki dan perempuan pada variabel konsumsi gula pada subjek (p<0,05). Selain itu, hasil penelitian menunjukkan bahwa ada korelasi antara status gizi (Indeks Massa Tubuh/IMT) (r=0,249, p=0,015), tingkat kecukupan energi (r=-0,411, p<0,000), protein (r=-0,335, p=0,000), karbohidrat (r=-0,336, p=0,000), kalsium (r=-0,328, p=0,001), zat besi (r=-0,290, p=0,004), kalium (r=-0,225, p=0,027), an konsumsi gula per hari (r=-0,305, p=0,003) dengan tekanan darah. Dengan demikian, hanya indeks massa tubuh yang berkorelasi positif dengan tekanan darah.
Palliative care needs of stroke patients at a tertiary care center in South India
Authors: Panicker Praveen , Iype Thomas , Appireddy Ramana , Ajithan Ayana , Lijimol A. S. , Sasikumar Asha , Dileep R. , Vijaya Nirmala , Booth Chris , Rajagopal M. R. 
Published: April 2024

Objectives:
Stroke survivors have palliative care needs in multiple domains, which are overlooked. Accurate estimation of these is pivotal in ensuring proper rehabilitation and planning interventions to improve quality of life (QoL). We aimed to assess the palliative care needs of stroke patients in various domains in a structured manner at the neurology service of a tertiary care center in South India.

Materials and Methods:
Seventy-five consecutive stroke patients presenting to the neurology service were recruited over six months with assessment across various domains including symptom burden, physical domain, activities of daily living (ADL), psychiatric/psychological domain, and QoL at baseline and with follow-up at one month and three months.

Results:
Despite improvement in the conventional stroke impairment measures among stroke survivors, there were significant unmet needs across various domains; 98% were severely or entirely dependent on ADL at three-month follow-up; and pain and insomnia were the most frequent (33% incidence) troubling symptoms encountered. There were substantial mental health related issues. The QoL measurement tools employed were the stroke impact assessment questionnaire (SIAQ), a novel tool and the World Health Organization Quality Of Life Brief Version (WHO-QOL-BREF). SIAQ scores at one month showed that 19 patients (42.22%) had their QoL severely affected, and 36 patients (80%) showed the same trend at the three-month follow-up. WHO-BREF scores showed that 27 (62%) did not report good QoL, and 32 (73%) were found not to be satisfied with their health at a one-month follow-up.

Conclusion:
There is a significant burden of unmet palliative care needs among stroke survivors in India across various domains.
Intracranial mycotic aneurysm rupture following cupping therapy
Authors: Dai Monami , Suzuki Kaima , Sato Hiroki , Tabata Shinya , Kume Haruka , Nishikata Masaya , Tamada Keita , Ooigawa Hidetoshi , Kurita Hiroki 
Published: April 2024

Background:
Cupping therapy is an alternative treatment that uses a small glass cup to suck the skin with a needle and has been used to manage skin problems and pain. However, serious complications have been reported. Herein, we describe a case of intracranial mycotic aneurysm rupture after cupping therapy.

Case Description:
A 25-year-old male patient presented with a headache and fever after cupping therapy for atopic dermatitis. He was diagnosed with infective endocarditis, and antibiotic therapy was initiated. After that, he suddenly lost consciousness, and head imaging revealed a cerebral hemorrhage due to a ruptured intracranial mycotic aneurysm. He underwent craniotomy, which was successful, and he was transferred to a rehabilitation center with a modified Rankin scale score of 2 at three months post-stroke.

Conclusion:
This case serves as a reminder of life-threatening infectious complication risks after cupping therapy. A patient who has a compromised skin barrier may experience serious adverse effects, especially when cupping is performed without implementing suitable infection prevention measures.
INFLUENCE OF PHYSICAL AND CHEMICAL COMPOSITION OF VARIETAL DRY WHITE WINES ON FOAMING ABILITY
Authors: КОШЕВАЯ В.И. , ОСЕЛЕДЦЕВА И.В. , СТРИБИЖЕВА Л.И. , ЧОМАЕВА Д.А. 
Published: April 2024

Получение высококачественных игристых вин является главной задачей виноделия. Одним из основ- ных показателей готового игристого вина являются пенистые свойства, которые зависят от способности исходного вина к пенообразованию. В связи с этим актуально исследование способности сухих белых вин к формированию пены и влияния различных компонентов – белков, фенольных веществ, аминокислот – на этот процесс. Объектами исследования являлись образцы вина, произведенные из винограда сортов Пино блан, Рислинг Рейнский и Шардо- не урожая 2022 года, выращенного в Темрюкском районе Краснодарского края. Способность формирования пены у опытных образцов определяли при помощи «Анализатора пенообразования», разработанного на базе кафедры технологии виноделия и бродильных производств им. профессора Мержаниана КубГТУ. Установлена связь между пенообразующей способностью вина и основными компонентами, влияющими на данный показатель. Проведе- на корреляционная зависимость показателя пенообразующей способности от массовых концентраций белков, фе- нольных веществ и аминокислот. Выявлено, что наибольшим потенциалом к формированию пены обладали вина из сорта Рислинг Рейнский и Шардоне. Полученные данные при дальнейшем исследовании могут быть использованы производителями игристых вин для оптимизации производственных процессов и повышения качества продукции.
Producing high-quality sparkling wines is one of the main tasks of winemaking. One of the main indicators of the finished sparkling wine is its foaming properties, which depend on the ability of the original wine to foam. In this regard, it is important to study the ability of dry white wines to form foam and the influence of various components – proteins, phenolic substances, amino acids – on this process. The objects of the study were samples of wine produced from Pinot Blanc, Rhine Riesling and Chardonnay grapes of the 2022 harvest, grown in the Temryuk region of the Krasnodar Territory. The ability to form foam in prototypes was determined using the «Foaming Analyzer», developed on the basis of the Department of Winemaking and Fermentation Technology named after Professor Merzhanian KubSTU. A connection has been established between the foaming ability of wine and the main components that influence this indicator. The correlation dependence of the foaming ability indicator on the mass concentrations of proteins, phenolic substances and amino acids was carried out. It was revealed that wines from the Rhine Riesling and Chardonnay varieties had the greatest potential for foam formation. The data obtained during further research can be used by manufacturers of sparkling wines to optimize production processes and improve product quality.
Potensi Bakteri Indigenous Pada Air Limbah Pencucian Bijih Bauksit Untuk Meremediasi Air Tercemar Logam Besi (Fe)
Authors: Maulidyana Frischa , Apriani Isna , Jumiati Jumiati 
Published: April 2024

Kegiatan pertambangan bauksit di Kalimantan Barat yaitu PT. ANTAM menghasilkan bijih bauksit. Senyawa pengotor pada bauksit dipisahkan dengan pencucian. Proses pencucian menghasilkan limbah cair dan padatan yang dialirkan ke kolam pengendapan. Kolam pengendapan rentan terjadi kebocoran dan penambahan volume kolam saat hujan. Kapasitas kolam dijaga dengan mengalirkan air ke lingkungan sehingga menimbulkan pencemaran, mengganggu ekosistem akuatik dan menjadi racun bagi organisme karena mengandung logam Fe yang melebihi baku mutu. Maka, perlu dipulihkan dengan bioremediasi bantuan bakteri indigenous. Tujuan penelitian untuk mengetahui jenis isolat bakteri indigenous pada air limbah pencucian bijih bauksit dan air rawa PT. ANTAM yang berpotensi meremediasi air limbah yang tercemar logam besi (Fe) dan untuk mengetahui pengaruh bakteri indigenous dalam meremediasi air limbah yang mengandung logam besi (Fe) dengan berbagai variasi konsentrasi air limbah. Hasil didapat jenis isolat bakteri indigenous yang berpotensi meremediasi air limbah yang tercemar logam besi yaitu Bacillus sp. dan Pseudomonas sp. Konsentrasi Fe setelah bioremediasi menunjukkan penurunan pada perlakuan reaktor limbah 25%, 75% dan 100%. Aktivitas bakteri Bacillus sp. dan Pseudomonas sp. berpotensi menurunkan konsentrasi Fe pada berbagai konsentrasi limbah serta Bacillus sp. memiliki potensi menurunkan Fe lebih baik karena lebih resisten terhadap lingkungan cemaran yang tinggi.
IDENTIFYING BARRIERS IN PUBLIC SECTOR DIGITAL TRANSFORMATION: A CASE STUDY IN INDONESIA CITY OFFICE FOR POPULATION ADMINISTRATION AND CIVIL REGISTRATION (COPACR) CONTEXT
Authors: Sonhaji Agus Imam , Anityasari Maria , ER Mahendrawathi 
Published: April 2024

Purpose: This paper presents a case study of the Surabaya City Office for Population Administration and Civil Registration (COPACR), which is currently undergoing digitization and digital transformation across all its civil registration service lines. This research identifies internal and external barriers relevant to digital transformation in the context of Surabaya COPACR.

Theoretical Framework: This study combines qualitative and quantitative methods to identify internal and external barriers relevant to the implementation of digital transformation in the COPACR sector. The barriers are validated through Focus Group Discussions (FGDs) applying the Analytic Hierarchy Process (AHP) and Expert Choice tools. Priority barriers are determined based on the highest relevance weight values from the perspectives of Top Management and Field Officers.

Design/Methodology/Approach: This research adopts an action research methodology, leveraging the researcher's position within the system to directly intervene and facilitate change. A mixed-method approach is employed, combining qualitative and quantitative methodologies. Twenty literature sources are utilized to identify internal and external barriers within public sectors to adopt digital transformation. A total of 63 barriers (33 internal and 30 external) are categorized and their relevance tested through Focus Group Discussions (FGDs). Barrier priorities are selected using the Analytic Hierarchy Process (AHP) method and expert choice tools.

Findings: The Surabaya COPACR in developing countries exhibits characteristics such as low employee motivation, inadequate officer competency, rigid bureaucratic structures, and limited innovation. With these conditions, the internal priorities for adopting digital transformation in Surabaya COPACR include lack of political support, traditional bureaucracy, organizational complexity, and lack of competency. External barriers include inflexible regulations, bureaucracy, lack of data standardization, and inadequate funding allocation.

Research, Practical & Social Implications: This research contributes theoretical insights into internal and external priority barriers that need to be considered to adopt digital transformation in the COPACR context of developing countries. The identified barriers can serve as references for public sectors with similar organizational characteristics in developing countries to design strategies for adopting digital transformation effectively.

Originality/Value: This study identifies internal and external barriers to digital transformation in the Surabaya COPACR context, involving assessments from both strategic (Top Management) and technical (Field Officer) perspectives.
Energy management system using artificial fish swarm speed optimized fuzzy controller based on a deep recurrent neural learning classifie
Authors: Jayanthi G. , Balachander K. 
Published: April 2024

Hybrid Electric Vehicles (HEVs) must ensure power demand through minimum fuel consumption and a control strategy. Existing control methods were easy to implement, showing quick response and good performance. Power demand is linked to numerous factors such as level of social and economic expansion, industrialization, urbanization, and technological growth. However, power demand problems like higher energy waste, poor quality, less accuracy, lack of robustness, and limited operating range were not reduced in existing controller methods. This paper presents an Artificial Fish Swarm Speed Optimization Fuzzy PID Controller (AFSSOF-PIDC). AFSSOFPIDC-DRNLC includes different layers in drive train management. Initially, different vehicle data is considered in the input layer and then sent to hidden layer 1. Fitness is identified by improved Artificial Fish Swarm Speed Optimization to find optimal values that minimize the power demand, and then send it toward hidden layer 2. A Mamdani Fuzzy PID Controller is used in hidden layer 2. If the fitness value of the vehicle information is less than the threshold value, fuel consumption is minimized in the HEV. Otherwise, consumption of fuel is not minimized in the HEV. Finally, energy management is achieved through minimal power demand. The results indicate that the performance of the proposed AFSSOFPIDC-DRNLC technique minimizes fuel consumption by increasing the performance of the controller as compared with existing methods.
Hubungan pola makan dan status gizi dengan keteraturan menstruasi pada mahasiswi Prodi Kedokteran Fakultas Kedokteran Universitas Malikussaleh
Authors: Rahmi Nita , Iskandar Iskandar , Mauliza Mauliza 
Published: April 2024

Menstruasi merupakan proses fisiologis yang dialami setiap wanita pada usia reproduktif. Proses fisiologis ini dipengaruhi beberapa faktor yang dapat menimbulkan gangguan menstruasi. Faktor seperti pola makan dapat berdampak pada asupan nutrisi makro maupun mikro seseorang yang kemudian mampu mempengaruhi fungsi organ reproduksi. Timbulnya gangguan menstruasi dapat menurunkan kualitas hidup seseorang, terutama kemampuan belajar pada mahasiswi. Banyaknya lemak dalam tubuh dapat menyebabkan memanjangnya siklus menstruasi. Penelitian ini bertujuan untuk melihat adanya Hubungan Pola Makan Dan Status Gizi Dengan Keteraturan Menstruasi Pada Mahasiswi Prodi Kedokteran Fakultas Kedokteran Universitas Malikussaleh. Jenis penelitian ini merupakan penelitian analitik observasional dengan menggunakan rancangan cross sectional. Pada penelitian ini digunakan teknik probability sampling dengan stratified random sampling untuk teknik pengambilan sampel. Besar sampel dalam penelitian ini sebanyak 185 responden yang telah memenuhi kriteria inkusi dan eklusi. Data yang digunakan dalam penelitian ini adalah data primer yang didapatkan melalui penyebaran kuesioner kepada responden. Analisis data pada penelitian ini menggunakan Chi Square. Hasil dari penelitian ini adalah didapatkan asupan lemak memenuhi sebanyak 129 responden (69,7%), sedangkan yang tidak memenuhi sebanyak 56 responden (30,3%). Asupan protein kategori memenuhi standar 84,9% dan yang tidak memenuhi standar 15,1%. Sedangkan asupan serat yang memenuhi standar sebanyak 82,2% dan yang tidak memenuhi standar sebanyak 17,8%. Status gizi responden dengan kategori kurus sebanyak 21 mahasiswi (11,4%), kategori normal sebanyak 105 mahasiswi (56,8%) dan kategori gemuk sebanyak 59 mahasiswi (31,9%). siklus menstruasi responden dengan siklus menstruasi yang teratur sebanyak 136 orang (73,5%) dan siklus menstruasi yang tidak teratur sebanyak 49 orang (26,5%). Kesimpulan penelitian ini: Terdapat hubungan antara pola makan dan status gizi dnegan keteraturan menstruasi.
Upaya Pengelolaan Hipertensi Dengan Pendekatan Pelayanan Dokter Keluarga
Authors: Putri Narisha Amelia , Zara Noviana 
Published: April 2024

Pasein perempuan berusia 62 tahun datang ke Puskesmas Kuta Makmur dengan keluhan sakit kepala yang semakin hari semakin memberat terutama dalam 1 minggu terakhir. Sakit kepala terkadang dirasakan seperti terikat dan tertimpa beban berat. Pasien juga mengeluhkan adanya nyeri dan rasa kaku pada bagian leher belakang. Dari hasil anamnesis didapatkan keluhan sudah dirasakan pasien sejak tahun 2002. Pasien sudah sering datang dan berobat ke Puskesmas. Pada pemeriksaan fisik didapatkan TD 160/110 mmHg, RR 21 x/menit, HR 81 x/menit, IMT 20,44 kg/m2. Data primer diperoleh melalui anamnesis dan pemeriksaan fisik dengan melakukan kunjungan rumah, mengisi family folder, dan mengisi berkas pasien. Penilaian dilakukan berdasarkan diagnosis holistik awal, proses, dan akhir kunjungan secara kuantitatif dan kualitatif. Intervensi yang dilakukan berupa upaya promotif, preventif, kuratif, rehabilitative dan upaya psikososial
PERBANDINGAN PENGGUNAAN CITRA LANDSAT 8 DAN SENTINEL 2 TERHADAP ANALISIS KESEHATAN MANGROVE DENGAN METODE NDVI DI TELUK JAKARTA
Authors: Hamdi Berry El , Al-Fariziz Muhamad Salman , Safitri Melyani , Amalia Ilma Nur , Nandi Nandi , Ridwana Riki 
Published: April 2024

Perbedaan pemanfaatan citra satelit dalam menganalisis Normalized Difference Vegetation Index sangat berpengaruh terhadap analissi luasan dalam klasifikasi kesehatan mangrove. Selain itu dengan adanya kebijakan pembatasan sosial berskala besar pada Maret 2020 hingga Desember 2020 menyebabkan adanya peningkatan kualitas lingkungan di Daerah Khusus Ibukota Jakarta terutama pada peningkatan kualitas kesehatan Mangrove. Hal tersebut terlihat pada tahun 2019 dengan menggunakan citra landsat memiliki luasan mangrove dengan klasifikasi kesehatan sangat buruk seluas 171,6 Ha. Berbanding terbalik pada tahun 2020 dengan citra yang sama, kesehatan mangrove yang memiliki kalsifikasi sangat buruk hanya seluas 18,1 Ha. Dan mengalami peningkatan pada tahun 2021 dengan citra landsat 8, yaitu sebesar 216,8 Ha. Sedangkan awal tahun 2021 yaitu bulan Maret yang dimana adanya peningkatan segala aktifitas manusia, yang setidaknya mempengaruhi pada penurunan kualitas lingkungan yang menyebabkan kualitas kesehatan mangrove semakin buruk. Maka dengan kata lain bahwa selain berbagai dampak negative dengan adanya pandemic covid-19 ini. Terdapat dampak positif bagi meningkatnya kualitas lingkungan akibat suatu kebijakan pembatasan segala akitifitas manusia dalam mencegah penurunan covid-19 ini. Hal tersebut dapat dilihat dengan pemanfaatan citra satelit Landsat 8 dan Sentinel 2a/b dalam melihat kesahatan vegetasi khusunya vegetasi mangrove dengan menggunakan Normalized Difference Vegetation Index.