bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Nucleoside and Oligonucleoside Boranophosphates: Chemistry and Properties
Authors: Li Ping , Sergueeva Zinaida A. , Dobrikov Mikhail , Shaw Barbara Ramsay 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Use of Lawesson′s Reagent in Organic Syntheses
Authors: Ozturk Turan , Ertas Erdal , Mert Olcay 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Metal 2‐Ethylhexanoates and Related Compounds as Useful Precursors in Materials Science
Authors: Mishra Shashank , Daniele Stephane , Hubert‐Pfalzgraf Liliane G. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis Using Aromatic Homolytic Substitution — Recent Advances
Authors: Bowman W. Russell , Storey John M. D. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Carbo‐mers: From Skeleton to Function
Authors: Maraval Valerie , Chauvin Remi 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthetic Studies on Fostriecin and Related Natural Products
Authors: Miyashita Kazuyuki , Ikejiri Masahiro , Tsunemi Tomoyuki , Matsumoto Ayumi , Imanishi Takeshi 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Atomistic Simulation of the Thermodynamic and Transport Properties of Ionic Liquids
Authors: Maginn Edward J. 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Non‐Reactive and Reactive Wetting of Liquids on Surfaces
Authors: Kumar Girish , Prabhu K. Narayan 
Published: January 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Modellbasierte Führungsstrategie für die Foulingminimierung in Membranbioreaktoren
Authors: Arellano‐Garcia H. , Drews A. , Kraume M. 
Published: January 2008

AbstractMembranbioreaktoren (MBR) sind eine noch vergleichsweise junge Technologie, deren Anwendung dem fundamentalen Verständnis der beteiligten Phänomene und ihrer Interaktionen z. T. vorauseilt. Die Auslegung der benötigten Membranfläche in MBR erfolgt bislang auf Basis von Experimenten. Im Verlauf der Filtration kommt es zu verschiedenen Ablagerungen auf und in der Membran. Im Laufe der Zeit tritt irreversibles Fouling auf, das chemische Reinigungen notwendig macht. Im vorliegenden Beitrag wird eine modellbasierte Führungsstrategie für die Fouling‐Minimierung in Membranbioreaktoren auf Basis der Auswertung von online verfügbaren Daten und optimierter Modell‐ sowie Parameteridentifikation entwickelt. Hierfür wird die strukturelle Identifizierbarkeit der zur Verfügung stehenden Modelle untersucht und ein Ansatz zur automatisierten Erkennung des aktuell herrschenden Filtrationsmechanismus implementiert.
Investigating Alanine–Silica Interaction by Means of First‐Principles Molecular‐Dynamics Simulations
Authors: Nonella Marco , Seeger Stefan 
Published: January 2008

AbstractIn our attempts to achieve a detailed understanding of protein–silica interactions at an atomic level we have, as a first step, simulated a small system consisting of one alanine in different protonation states, and a hydroxylated silica surface, using a first‐principles molecular‐dynamics technique. The simulations are carried out in vacuo as well as in the presence of water molecules. In the case of a negatively charged surface and an alanine cation, an indirect proton transfer from the alanine carboxylic group to the surface takes place. The transfer involves several water molecules revealing an alanine in its zwitterionic state interacting with the neutral surface through indirect hydrogen bonds mediated by water molecules. During the simulation of the zwitterionic state the ammonium group eventually establishes a direct NH⋅⋅⋅OSi interaction, suggesting that the surface–amino group interaction is stronger than the interaction between the surface and the carboxylic group. In vacuum simulations, the amino group exhibits clearly stronger interactions with the surface than the carboxylic group.
Therapeutic education of diabetic patients
Authors: Golay A. , Lagger G. , Chambouleyron M. , Carrard I. , Lasserre‐Moutet A. 
Published: January 2008

AbstractTherapeutic patient education is a patient‐centred approach, focussed on patients' needs, resources, values and strategies. It allows patients to improve their knowledge and skills not only concerning their illness but also their treatment. It brings a better quality of life, a greater therapeutic compliance and a reduction in complications. The most difficult part of therapeutic patient education occurs when patients must change their behaviour. Motivational interviewing and cognitive‐behavioural approaches contribute greatly here and allow both the preparation and support of patients during progressive ‘step by step’ change. The work on resistance to change is fundamental, and ambivalence when faced with the choice of a new way of life must be measured, discussed and negotiated. Patients become partners and we become ‘coaches’. The negotiation of objectives must allow patients to choose their own strategies, which normally should cost them the least possible, psychologically, and bring them the maximum benefit.The efficiency of therapeutic patient education no longer needs to be proved: 80% less amputations over 10 years in diabetic patients; 50% maintenance of weight loss over 5 years, etc.In conclusion, therapeutic education is part of a humanistic medical approach centred on patients; it allows them to be active participants in their own treatment with the aim of improving their quality of life and therapeutic compliance, as well as reducing potential complications. Thus, health care professionals teach, inform, train, negotiate with, motivate and accompany patients in the long‐term follow‐up of their illness. Copyright © 2008 John Wiley & Sons, Ltd.
A novel probe for chemiluminescent image detection of proteins in two‐dimensional gel electrophoresis
Authors: Liu Jia , Ouyang Jin , Baeyens Willy R. G. , Delanghe Joris R. , Wang Zhenzhen , Liu Jinxiu , Zhang Huiying 
Published: January 2008

AbstractCarrier ampholytes were found to enhance the chemiluminescence (CL) emission from the 3‐aminophthalic hydrazide (luminol)‐hydrogen peroxide system. They can be used as a chemiluminescent probe for rapid detection of major proteins in gels. This probe attracted much interest due to its ability to attach proteins, and to the possibility to combine it with separation techniques generating the CL emission directly. Increased signal intensity was achieved employing optimized concentrations of the carrier ampholyte enhancer. The binding of carrier ampholyte to proteins was found to occur at the pI of the proteins. Proteins from different regions of the gels were identified by their matrix‐assisted TOF mass spectra and by appropriate database search, the results illustrating the possibility of major protein detection in human serum. Direct CL image detection with the carrier ampholyte probe can be applied for the detection of characteristic proteins in patients, i.e., proteins which cannot be detected without the probe.
Protein extraction for 2‐DE from the lamina of Ecklonia kurome (laminariales): Recalcitrant tissue containing high levels of viscous polysaccharides
Authors: Nagai Kouhei , Yotsukura Norishige , Ikegami Haruka , Kimura Hajime , Morimoto Koichi 
Published: January 2008

AbstractExtraction of proteins from the tissues of laminarialean algae, i.e. kelp, is difficult due to high levels of nonprotein interfering compounds, mainly viscous polysaccharides. To establish proteomic analysis of kelp species, an ethanol/phenol extraction method was developed and compared to other popular methods. Proteins were extracted with phenol from crude protein powder, obtained by homogenizing the kelp tissues in ice‐cold ethanol. The ethanol/phenol method produced high‐quality proteins of the highest purity from the lamina of Ecklonia kurome, one of the Japanese dominant laminarialean algae. This method gave well‐resolved 1‐D SDS‐PAGE or 2‐DE images with low background and the highest number of bands or spots. In particular, proteins with neutral to basic pI′s were efficiently extracted. Furthermore, 27 spots on the 2‐DE gel were extensively identified by MALDI‐TOF/TOF analysis. To the best of our knowledge, this is the first report of a protocol for protein extraction from kelp tissues that gives satisfactory 2‐D protein profiles. It is expected that the protocol can be applied to other algae tissues or other recalcitrant plant tissues containing high levels of nonprotein interfering compounds.
Anaplastic lymphoma of the cervical esophagus presenting as a tracheoesophageal fistula
Authors: Joshi Anil , Fields Paul , Simo Ricard 
Published: January 2008

AbstractBackgroundAnaplastic kinase‐1 positive lymphoma (ALK‐1) is a very rare but distinct pathologic entity. ALK‐1 lymphoma tends to affect the bone marrow, skin, lungs, soft tissue, but very rarely the gastrointestinal tract.MethodsWe report a case of ALK‐1 positive lymphoma presenting as a tracheoesophageal fistula. The clinical presentation, histopathology, and management outcome are all discussed.ConclusionALK‐1 positive lymphoma of the upper aerodigestive involvement is extremely rare. An unusual presentation such as pharyngeal pouch with vocal cord palsy should suggest pathology. Histopathologic analysis can be difficult and immunohistochemical studies will aid are of paramount importance in the diagnosis and help in subsequent management and also act as prognostic indicators. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Genetic alterations in juvenile nasopharyngeal angiofibromas
Authors: Coutinho‐Camillo Cláudia M. , Brentani M. Mitzi , Nagai Maria A. 
Published: January 2008

AbstractJuvenile nasopharyngeal angiofibroma (JNA) is a rare benign neoplasm of the nasopharynx that accounts for 0.5% of all head and neck tumors. Although histologically benign in appearance, JNAs are locally aggressive and destructive, spreading from the nasal cavity to the nasopharynx, paranasal sinuses, and orbit skull base with intracranial extension. The gender selectivity of JNA and the relatively young age at diagnosis suggest hormone‐dependent development. Hormonal disorders have been reported in patients with JNA, and androgen and estrogen receptors have been identified in tumor tissue; however, a hormonal influence on JNA is controversial. Recent studies have attempted to further delineate the pathogenesis of JNA through analysis of genetic and molecular changes. Understanding of the molecular mechanisms involved in JNA might improve prevention, prognosis, and treatment of this tumor. In this review, we discuss published studies addressing the possible molecular pathways that might be involved in the development of JNA. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Oncologic outcomes of transoral laser surgery of supraglottic carcinoma compared with a transcervical approach
Authors: Cabanillas Rubén , Rodrigo Juan Pablo , Llorente Jose Luis , Suárez Carlos 
Published: January 2008

AbstractBackgroundTo evaluate the oncologic effectiveness of transoral laser surgery of supraglottic cancer, we compared a group of patients treated with laser surgery, with a stage‐matched group treated with a transcervical approach.MethodsTwenty‐six patients who underwent laser surgery were retrospectively compared with 26 patients who underwent a transcervical approach. In both groups, the patients were classified as follows: 8% stage I, 23% stage II, 46% stage III, and 23% stage IV.ResultsThe 5‐year disease‐specific survival rates were 80% for the laser group and 72% for the transcervical group (p = .5). The ultimate 5‐year laryngeal preservation rate was 86% in the laser group and 80% in the transcervical group (p = .6). In both arms, all patients classified as T1 and T2 who survived 5 years after the surgical treatment of tumors retained the larynx.ConclusionsThe oncologic results of transoral laser surgery of supraglottic cancer are equivalent to those of the classic transcervical approach. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Fluorescent labeled anti‐EGFR antibody for identification of regional and distant metastasis in a preclinical xenograft model
Authors: Gleysteen John P. , Newman J. Robert , Chhieng David , Frost Andra , Zinn Kurt R. , Rosenthal Eben L. 
Published: January 2008

AbstractBackgroundDetection of regional and distant metastatic disease has significant implications for patient management. Fluorescent imaging may be a useful technique for metastasis detection and removal.MethodsAnti–epidermal growth factor receptor antibody (cetuximab) and isotype‐matched control antibody (immunoglobulin G [IgG]) were labeled with a near‐infrared fluorophore (Cy5.5), then systemically administered to mice with tumors resulting from either intraoral or intravenous injections of head and neck squamous cell carcinoma. Mice were sacrificed before undergoing fluorescent stereomicroscopy to assess pulmonary or cervical lymph node metastasis. Fluorescent areas were serially excised until wound bed demonstrated negative fluorescence.ResultsMice bearing pulmonary metastases displayed diffuse background after IgG–Cy5.5 injection, but demonstrated a speckled fluorescent pattern across lung surface following cetuximab–Cy5.5 injection. Mice bearing cervical metastases demonstrated clear fluorescence of primary tongue tumor and bilateral cervical nodes. Fluorescence correlated with histopathology.ConclusionThese data suggest that cetuximab–Cy5.5 may have clinical utility in the detection and guided the removal of regional and distant micrometastasis. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Effect of polymer architecture on surface properties, plasma protein adsorption, and cellular interactions of pegylated nanoparticles
Authors: Sant Shilpa , Poulin Suzie , Hildgen Patrice 
Published: January 2008

AbstractThe aim of the present study was to evaluate the cellular interaction of nanoparticles (NPs) prepared from different pegylated polymers and elucidate the effect of polymer architecture, for instance, grafted versus block copolymer on their cellular uptake. Fluorescein‐labeled NPs of four different polymers, viz., poly(D,L‐lactide) (PLA), poly(ethylene glycol)1%‐graft‐poly(D,L‐lactide) (PEG1%‐g‐PLA), poly(ethylene glycol)5%‐graft‐poly(D,L‐lactide) (PEG5%‐g‐PLA), and (poly(D,L‐lactide)‐block‐poly(ethylene glycol)‐block‐poly(D,L‐lactide))n multiblock copolymer (PLA‐PEG‐PLA)n were prepared. These NPs were characterized for their size, ζ‐potential, and surface morphology. XPS studies revealed possibility of chemical interaction between PLA COOH groups and PVA OH groups, thus making it difficult to be washed off the NP surface completely. Grafted polymer NPs showed more surface PEG coverage than (PLA‐PEG‐PLA)n despite of their comparatively lower PEG content. The results of surface properties were translated into protein binding showing least amount of proteins bound to grafted copolymer NPs as against multiblock copolymer NPs. NPs showed no toxicity to RAW 264.7 cells. Cellular uptake of NPs was temperature and concentration‐dependent as well as involved clathrin‐mediated processes. Thus, this study confirms the importance of polymer architecture in determining the surface properties and hence, protein binding and cellular interactions of NPs. Also, it was shown that grafted copolymer NPs reduced macrophage uptake as compared to multiblock copolymer although mechanisms different than phagocytosis were involved. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
Polyurethane scaffold formation via a combination of salt leaching and thermally induced phase separation
Authors: Heijkants R. G. J. C. , van Calck R. V. , van Tienen T. G. , de Groot J. H. , Pennings A. J. , Buma P. , Veth R. P. H. , Schouten A. J. 
Published: January 2008

AbstractPorous scaffolds have been made from twopolyurethanes based on thermally induced phase separation of polymer dissolved in a DMSO/water mixture in combination with salt leaching. It is possible to obtain very porous foams with a very high interconnectivity. A major advantage of this method is that variables like porosity, pore size, and interconnectivity can be independently adjusted with the absence of toxic materials in the production process. The obtained compression moduli were between 200 kPa and 1 MPa with a variation in porosity between 76 and 84%. Currently the biological and medical aspects are under evaluation. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
Osteogenic differentiation of human mesenchymal stem cells on chargeable polymer‐modified surfaces
Authors: Guo Likun , Kawazoe Naoki , Hoshiba Takashi , Tateishi Tetsuya , Chen Guoping , Zhang Xingdong 
Published: January 2008

AbstractPolystyrene cell‐culture plates modified with positively charged polyallylamine (PAAm) and negatively charged poly(acrylic acid) (PAAc) and unmodified plate were used for the culture of human mesenchymal stem cells (MSCs) to study the effect of surface electrostatic properties on their osteogenic differentiation. All of these surfaces supported cell adhesion and proliferation. However, the cells adhered, spread, and proliferated somewhat more quickly on the PAAm‐modified surface than they did on the PAAc‐modified and control surfaces. Osteogenic differentiation was examined by alkaline phosphatase (ALP) staining, alizarin red S staining, and gene‐expression analysis. The MSCs cultured on the three kinds of surfaces in the presence of dexamethasone were positively stained with ALP and alizarin red S staining, while the cells cultured without dexamethasone were not positively stained. Gene‐expression analyses using real‐time PCR indicated that MSCs cultured on these surfaces in the presence of dexamethasone expressed osteogenic marker genes, encoding ALP, osteocalcin, bone sialoprotein, osteopontin, and type I collagen. These results indicate that the positively charged, negatively charged, and unmodified surfaces supported osteogenic differentiation, and that their effect required the synergistic effect of dexamethasone. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
Novel Hyaluronan‐Based Nanocarriers for Transmucosal Delivery of Macromolecules
Authors: de la Fuente María , Seijo Begoña , Alonso María J. 
Published: January 2008

AbstractThe goal of this work was to design a new nanocarrier composed of the glycosaminoglycan hyaluronan and the polysaccharide chitosan, intended for the transmucosal delivery of macromolecules. The nanoparticles were characterized for their size and superficial charge. The incorporation of hyaluronan was verified by agarose gel electrophoresis and Fourier transform infrared (FT‐IR) spectroscopy. The ability of the nanosystems to encapsulate macromolecules was studied taking the hydrophilic protein bovine serum albumin (BSA) and the hydrophobic polypeptide Cyclosporine A (CyA) as models. Results showed that the experimental conditions could be conveniently adjusted in order to modulate the physicochemical properties of the carriers and their composition. Moreover, the nanoparticles provided high association efficiencies of the selected macromolecules.magnified image
Complete assignment of the 1H and 13C NMR spectra of garciniaphenone and keto‐enol equilibrium statements for prenylated benzophenones
Authors: Derogis Priscilla B. M. C. , Martins Felipe T. , de Souza Thiago C. , de C. Moreira Maria E. , Souza Filho José D. , Doriguetto Antonio C. , de Souza Kamila R. D. , Veloso Marcia P. , Dos Santos Marcelo H. 
Published: January 2008

AbstractThis article reports the structural elucidation by IR, UV and MS spectroscopic data along with 1H and 13C NMR chemical shift assignments of two benzophenones isolated from the fruit pericarp of Garcinia brasiliensis Mart. (Clusiaceae): garciniaphenone, (1R,5S,7S)‐3‐benzoyl‐4‐hydroxy‐6,6‐dimethyl‐5,7‐di(3‐methyl‐2‐butenyl)bicyclo[3.3.1]non‐3‐ene‐2,9‐dione, a novel triprenylated benzophenone; and 7‐epi‐clusianone, a tetraprenylated benzophenone that has already been extracted from another species of the same family. Furthermore, the keto‐enol tautomeric equilibrium at solution‐state was described for these compounds by 1D and 2D NMR spectral methods and one attempt to rationalize the different ratios between the noted tautomers was based on stereochemical features. Copyright © 2008 John Wiley & Sons, Ltd.
Energy Efficient Emulsion Polymerization Strategies
Authors: Goikoetxea Monika , Heijungs Reinout , Barandiaran María J. , Asua José M. 
Published: January 2008

AbstractPolymerization strategies aiming at further reducing the environmental impact of the already “green” emulsion polymerization process were investigated. Life cycle assessment showed that non‐isothermal strategies starting at low temperature resulted in an environmental impact lower than the isothermal ones. Nevertheless, the major part of the environmental impact was due to raw materials. The effect of the polymerization strategy on polymer microstructure was investigated.magnified image