bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of self-medication with analgesics among rural community of South India
Authors: S J Naresh Kumar , Sali Ramees M , Mokhasi Varsha R 
Published: March 2024

World Health Organization defines self-medication (SM) as the self-administration of a medication in the absence of a current prescription and/or without consulting a healthcare professional. Analgesics are the most commonly abused drug as a self-medication for relieving pain of any kind among the people. Our aim was to assess the prevalence of self- medication with analgesics and find the social factors associated among the rural people in Southern India. A community based cross sectional study using cluster sampling technique, four villages (clusters) were randomly selected in a rural District and among 460 respondents belonging to age group 18 to 60 years were interviewed. The mean age in years was 48.4 ± 15.5. About 182(39.6%) were illiterates and many respondents belonged to Agricultural laborers 350(76.1). Self-medication with analgesics is practiced by 24.8% of the respondents. Reason for self-medication was to reduce the out-of-pocket expenditure (72.4%). About 65.8% respondents purchased analgesics over the counter from pharmacy. The prevalence of self‑medication with analgesics was relatively high which is a threat for the community and can lead to multi organ damage to among rural people. Universal policy on drug selling over the pharmacy counter should be strictly implemented.
Prevalence and determinants of overweight and obesity among adolescent school children of Rajkot city, India
Authors: Mangrola Nidhi Y , Mahajan RG , Gajera Kshama D , Patel Kuntalkumar H. 
Published: March 2024

Adolescent obesity is becoming more prevalent due to changing lifestyles, and it has negative effects like a higher incidence of non-communicable diseases. Identification of risk factors leading to the rapid rise in adolescent obesity is a crucial first step in preventing and controlling it. Therefore, this study was carried out in Rajkot. The primary objective was to find the prevalence of obesity among the school going adolescents aged 14-19 years and to identify the determinants associated with obesity. A cross-sectional study among the adolescents studying in school was carried out by using multistage sampling method. A predesigned questionnaire with personal and family history and details of dietary habits and physical activity was filled by the participants. Anthropometric measurements of the participants including height, weight, waist and hip circumference were taken. Out of total 1120 participants, 25.8% were underweight, 11.1% were overweight and 6.9% were obese. Overweight and obesity was significantly associated with the occupation of participant’s father and mother, lack of physical activity, more screen time, non-vegetarian diet and daily consumption of carbonated drinks and chocolates. (p&#60;0.001). The determinants like physical activity and dietary habits were found to be associated with overweight and obesity. Modifying one's lifestyle can be very helpful in preventing adolescent obesity as well as developing healthy routines for later life.
To study thyroid profile in CKD patients in Eastern Uttar Pradesh
Authors: Srivastava Anupam , Mittal Mahim , Awasthi Minakshi , Rai Priyanka , Goel Mahima 
Published: March 2024

Chronic kidney disease (CKD) remains a universal pandemic that has evolved into a serious public health problem that imposes a significant socioeconomic burden. Thyroid profile is disrupted in CKD patients due to aberrant thyroid hormone metabolism. The purpose of our study was to assess thyroid function in people who had chronic renal disease (CKD).According to the inclusion-exclusion criteria, this cross-sectional observational research enrolled 150 chronic renal disease patients.All patients who met the above criteria underwent a detailed history as well as a general and systemic examination. Thyroid function tests, USG entire abdomen, chest X-ray, ECG, and 2D Echocardiogram, were performed. There were 84 men and 66 women among the 150 CKD patients. Thyroid hormone abnormalities were found in 93.3 % of the individuals. 14.7 % of the participants had hypothyroidism, 14.7 % had low T3 and T4 readings, 10% had low T4 values alone, 38 % had low T3 only, and 17% had subclinical hypothyroidism. Low T3 levels (58 %) were the most prevalent thyroid anomaly, with or without low T4 or elevated TSH levels. Low T3 levels were more common in patients with advanced CKD.Thyroid hormone abnormalities are linked to different stages of chronic renal disease.
Efficacy of Isosorbide dinitrate and Hydralazine combination in non ischemic dilated cardiomyopathy in a tribal based population at a tertiary care hospital
Authors: Sau Saikat , Mukherjee Lina , Sau Sourav 
Published: March 2024

Non ischemic dilated cardiomyopathy is an important cause of heart failure and cardiovascular mortality. Numerous pharmacologic therapies have been applied from the ancient era for treatment. Some of them have shown improve morbidity. From various literatures it was concluded that combination therapy with H-ISDN in addition to conventional medicines are very effective in black population group. In our study we have tried to establish the efficacy of fixed dose drug combination (Hydralazine + Isosorbide dinitrate) to alleviation of heart failure symptoms and mortality benefit if any. : Patient in NYHA 3 or ambulatory class 4 were included in study. Total two hundred populations were included in the prospective study. One hundred patients were treated by conventional optimum medications for heart failure including ACE inhibitors, ARBs. One hundred patients were given ISDN+Hydralazine (fixed dose) in addition to conventional medicines.: Mean age of study and controlled group was 62.5 years and 61.4 years respectively. Base line mean ejection fraction in control group was 33% and study group was 33%. After a mean one and half year follow up 61% of patient population achieved NYHA 2 in case group and 53% in control group. We assess the NT pro BNP level in both group of population at baseline and every six month interval. There is significant reduction in BNP level in study patients. 72% achieved below baseline cut off value for the age in control. In control population 51% achieved the estimated BNP value cut off for age. : Significant scope remains to improve the outcome for these patients through research related to use of H-ISDN in heart failure patients.
Attenuation of hemodynamic response to laryngoscopy and endotracheal intubation using oral ivabradine – Randomised controlled trial
Authors: Bhuvana S , P Kanimozhi  , Sekar Arun , Latha N 
Published: March 2024

Endotracheal intubation is one of the most common procedures, and anesthesiologists play an important role in patient care. During laryngoscopy and intubation, the patient can experience rapid and drastic hemodynamic changes that are potentially fatal. The purpose of this study is to know the efficacy of ivabradine in attenuating the hemodynamic response to laryngoscopy and endotracheal intubation. In this prospective randomised double-blinded study, fifty patients belonging to ASA 1 and 2 were randomised to group A - ivabradine 5mg (first dose on the evening before the day of surgery and the second dose one hour before intubation). Patients in group B received tablet MVT (placebo) (first dose on the evening before the day of surgery and the second dose one hour before intubation). Patients in group A showed attenuation of heart rate during laryngoscopy and intubation till 10minutes after intubation. Patients in group B showed a rise in blood pressure during laryngoscopy and intubation till 10 minutes after intubation. Patients in group A and group B showed no significant difference in hemodynamics when monitored intraoperatively. All patients recovered fully from anaesthesia and had no complications such as severe bradycardia. Ivabradine effectively attenuates the hemodynamic stress response without a fall in blood pressure and without severe bradycardia.
A study on the management of patients with retinopathy of prematurity in a tertiary care setting
Authors: Sethy Abinashi Sabyasachi , Sethi Santosh Kumar , Sharma Jyotsna , Murma Mangal Charan , Parida Subhabrata 
Published: March 2024

Retinopathy of rashness (ROP) is a critical reason for youth visual deficiency which gives a window period to screening & treatment prior to advancing to an extreme structure having poor visual result. Universally, no less than 50,000 kids are visually impaired because of ROP & an extra obscure number will be outwardly impeded or blind in one eye. To evaluate the administration of patients with Retinopathy of rashness & its result of the treatment applied in a tertiary level neonatal unit in the territory of Odisha. It is a clinic based unmistakable (cross-sectional) study, done from September 2019 to October 2021 done at SNCU of SCBMCH, Cuttack & SNCU, NICU of Sardar Vallabh bhai Patel Postgraduate Foundation of Pediatrics (SVPPGIP), Cuttack, Odisha who qualify the incorporation standards. During the review time of almost 2 years, 310 children were evaluated for ROP in which 117 were viewed as sure for ROP. The frequency of ROP in our review was 37.7%. ROP is viewed as related with the accompanying gamble factors in our review like low gestational age, low birth weight, oxygen treatment, RDS, paleness, blood bonding & septicemia, numerous births, hyperbilirubinemia with low birth weight & low gestational age & oxygen treatment being the main ones. Out of 31 cases treated with Avastin infusion, 26 gave indications of relapse till 2 months follow up & just 5 of them didn't give indications of relapse after infusion Bevacizumab. Those 5 children were treated with retinal removal by LASER photocoagulation following 10 days of beginning treatment, who gave indications of relapse till 2 months follow up. Legitimate screening & the executives of ROP can prompt counteraction of movement of infection to a more extreme stage with poor visual guess, consequently decreasing the weight of experience growing up visual deficiency. Intra vitreal hostile to VEGF infusion can be utilized as essential treatment for treatment justified ROP cases however more examination is expected to figure out the drawn out incidental effect profile of these medications.
Responsabilidad extracontractual del Estado por actos de vandalismo:
Authors: Jaimes Reyes Alba Marcela , Forero Guerrero María Victoria 
Published: March 2024

Desde hace varias décadas, los actos de vandalismo ejecutados por estudiantes de las universidades públicas, como mecanismo de protesta contra el gobierno de turno, ha sido una práctica común, que se fortalece como consecuencia de los límites que enmarcan el ejercicio de fuerza por parte del Estado; cuando tiene ocurrencia la manifestación violenta, contraria a la protesta pacífica protegida constitucionalmente, acontecen daños tanto en bienes públicos como privados, dejando a ciudadanos ajenos a la protesta siendo víctimas de daños en su patrimonio, afectaciones que no tienen la obligación de soportar y que por ende, hace necesario el análisis del deber de reparación en sede de responsabilidad extracontractual del Estado, determinando el título de imputación que le sería aplicable y los elementos requeridos para llegar a su configuración.
Compact Viscosity Sensors for Downhole Enhanced Oil Recovery Polymer Fluid Degradation Monitoring
Authors: Gonzalez Miguel , Ayirala Subhash , Maskeen Lyla , AlSofi Abdulkareem 
Published: March 2024

Summary
There are currently no technologies available to measure polymer solution viscosities at realistic downhole conditions in a well during enhanced oil recovery (EOR). In this paper, custom-made probes using quartz tuning fork (QTF) resonators are demonstrated for measurements of viscosity of polymer fluids in the laboratory. The electromechanical response of the resonators was calibrated in simple Newtonian fluids and in non-Newtonian polymer fluids at different concentrations. The responses were then used to measure field-collected samples of polymer injection fluids. In the polymer fluids, the measured viscosity values by tuning forks were lower than those measured by the conventional rheometer at 6.8 s−1, closer to the solvent viscosity values. However, the predicted rheometer viscosity vs. QTF-measured viscosity showed a distinct exponential correlation (R2=0.9997), allowing for an empirical calibration between the two viscometers for fluids having the same solvent and polymer compositions. The QTF sensors produced acceptable viscosity measurements of polymer fluids within the required polymer concentration ranges used in the field and predicted field sample viscosities with less than 1–2 cp (or 10–20%) error from the rheometer data. Results were validated based on separate independent tests where the devices were used to measure the viscosity of Newtonian fluids and non-Newtonian polymer fluids in a series of consecutive dip tests, simulating more realistic usage. These devices can be used to measure either the “relative” viscosity changes from a polymer solution prior and post-injection or to measure a “calibrated” viscosity via empirical exponential correlation. The compact QTF sensors developed in this study can be easily integrated into portable systems for laboratory or wellsite deployment as well as logging tools for downhole deployment. This work also demonstrates the ability of these QTF devices to make sensitive viscosity measurements at high-frequencies, opening opportunities for their use in high-frequency rheology studies of EOR fluids.
Controlling response order without relying on stimulus order – Evidence for flexible representations of task order
Authors: Kürten Jens , Strobach Tilo , Huestegge Lynn 
Published: March 2024

Abstract
In dual-task situations, both component tasks are typically not executed simultaneously but rather one after another. Task order is usually determined based on bottom-up information provided by stimulus presentation order, but also affected by top-down factors such as instructions and/or differentially dominant component tasks (e.g., oculomotor task prioritization). Recent research demonstrated that in the context of a randomly switching stimulus order, task order representations can be integrated with specific component task information rather than being coded in a purely abstract fashion (i.e., by containing only generic order information). This conclusion was derived from observing consistently smaller task-order switch costs for a preferred (e.g., oculomotor-manual) versus a non-preferred (e.g., manual-oculomotor) task order (i.e., order-switch cost asymmetries). Since such a representational format might have been especially promoted by the sequential stimulus presentation employed, we investigated task-order representations in situations without any bottom-up influence of stimulus order. To this end, we presented task stimuli simultaneously and cued the required task-order in advance. Experiment 1 employed abstract order transition cues that only indicated a task-order repetition (vs. switch) relative to the previous trial, while Experiment 2 used explicit cues that unambiguously indicated the task-order. Experiment 1 revealed significant task-order switch costs only for the second task (of either task order) and no order-switch cost asymmetries, indicating a rather generic representation of task order. Experiment 2 revealed task-order switch costs in both component tasks with a trend toward order-switch cost asymmetries, indicating an integration of task order representations with component task information. These findings highlight an astonishing flexibility of mental task-order representations during task-order control.
Brevibacillus choshinensis Restricts Harmful Eurygaster integriceps in Wheat-Sown Fields and Enhances Beneficial Insect Population
Authors: DİLMEN Halil , ÇIĞ Fatih , CERİTOĞLU Mustafa 
Published: March 2024

Abstract

This study was carried out to determine the effects of plant growth promoting bacteria (Brevibacillus choshinensis) on Eurygaster integriceps Puton, 1881 (Hemiptera: Scutelleridae) and the predators Chrysoperla carnea (Stephens) (Neuroptera: Chrysopidae) and Coccinella septempunctata L. (Coleoptera: Coccinellidae) at 2022-2023 season. The study was laid out in according to complete randomized design with three replications including areas with and without Brevibacillus choshinensis application. Sampling was carried out every 7 days until the harvest period. Predator insect species E. integriceps, C. carnea and C. septempunctata found in wheat plots were determined by using visual counting method. According to results, an average of 0.53 E. integriceps was found in the control plots, while an average of 0.2 in all B. choshinensis -treated areas. In addition, when the results were examined in terms of beneficial species, an average of 2.0 beneficial species was found in the control plots and an average of 11.4 in the plots where B. choshinensis was applied. The effect on all insect numbers was determined as 6.6 in the control plots, while an average of 13.7 insects was counted in the B. choshinensis applied plots. As a result, it was determined that B. choshinensis applications affected the average number of insects on the cultivated plant and as a result of the analyzes, there was a statistical difference compared to the control. It is thought that B. choshinensis can be an alternative bio-insecticide that can be used to control the harmful insect population and to encourage the beneficial insect population.
Informal recycling sector contribution to plastic pollution mitigation: A systematic scoping review and quantitative analysis of prevalence and productivity
Authors: Cook Ed , Cano Nathalia Silva de Souza Lima , Velis Costas A. 
Published: March 2024

Abstract

Ongoing negotiations for a ‘Legally Binding Instrument on Plastic Pollution’ recognise the substantial contribution made by the informal recycling sector (IRS - waste pickers) to plastic pollution mitigation as part of just transition. Negotiating parties will require baseline evidence of the sector’s activities to inform the development of local and national actions plans. To this, we carried out a review of IRS prevalence and productivity following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) method followed by extensive (statistical) data analytics. Waste pickers represent median 0.2% (interquartile range – IQR: 0.1-0.5%) of the urban population worldwide, collecting between 20 kg and 80 kg of engineered materials for recycling each day, of which 30% (mean wt. ar) are plastics. We identify substantial shortcomings in most methodologies used to gather data on the IRS, introducing epistemic uncertainty into some previous estimates of the sector’s activity. We recommend development of a standardised resource-efficient method of sampling and data gathering, suitable for implementation at municipal/local scale. Our work offers verifiable quantitative knowledge on the sector’s activities to date, suitable for use in plastic pollution quantification models and local/national action plans required to baseline and monitor progress towards multilateral targets.
CCT6A promotes cell proliferation in colon cancer by targeting BIRC5 associated with p53 status
Authors: Liu Huawen , Zhang Han , Zheng Taotao , Qin Chuan , Zhang Xinyue , Lin Han , Huang Xiaoping , Liu Qiang , Chang Shichuan , Zhang Li , Guo Jing , Zhang Yao , Bian Chunxiang 
Published: March 2024

Abstract

Chaperonin-containing TCP-1 (CCT) is a complex of proteins essential for cancer progression. CCT6A, the ζ subunit of CCT, contributes to tumorigenesis in various human cancers, but its function remains unclear. CCT6A had significantly higher expression in colon cancer than other CCT subunits, was upregulated in cells and clinical samples, and was correlated with an unfavorable prognosis among colon-cancer patients. GSEA results suggested that CCT6A plays a role in cellular-process signaling pathways, including the cell cycle, p53, and apoptosis. CCT6A effectively suppressed colon-cancer cell growth in vitro and in vivo; CCT6A interacted with wild-type p53 (Wtp53) and mutant p53 (Mutp53), but only inhibited Mutp53 degradation. BIRC5 was found to act downstream of CCT6A. In Wtp53 cells, CCT6A inhibition significantly reduced BIRC5 expression independent of Wtp53 levels. Conversely, in Mutp53 cells, CCT6A inhibition of BIRC5 mainly depended on Mutp53 levels; BIRC5 downregulation required Mutp53 disruption through CCT6A inhibition. Additionally, combined CCT6A knockdown and Wtp53 overexpression in Mutp53 cell lines effectively suppressed cell proliferation. It is concluded CCT6A is a potential oncogene that influences BIRC5 through distinct pathways in Wtp53 and Mutp53 cells.
Pollution indices as useful tools for comparative potential health risks of nickel in water-soil-fodder-animals food chain in relation to spatial and temporal fluctuations
Authors: Khan Zafar Iqbal , Raza Hamid , Ahmad Kafeel , Ashfaq Asma , Nadeem Muhammad , Ashraf Muhammad Arslan , Riaz Naila , Zubair Faiza , Alrefaei Abdulwahed Fahad , Almutairi Mikhlid H. , Mehmood Naunain , Batool Aima Iram , Memona Hafsa , Noorka Ijaz Rasool , Ugulu Ilker 
Published: March 2024

Abstract

Contamination of fodder species with elevated levels of metallic compounds holds significant epidemiological relevance, as it serves as the primary gateway for the introduction of these elements into the food chain. This investigation was directed to ascertain the ecological and health hazard of nickel contamination through various indices in food chain resulting from the dietary consumption of commonly ingested fodder crops cultivated on contaminated sites in the proximity of Sahiwal (Sargodha) and Soone Valley (Khushab), Punjab, Pakistan. Samples of water, soil, forages, ruminant’s blood, feces, and milk were collected from two sites; Soone Valley (Site_1) and Sahiwal (Site_2) in summer (Season_1) and winter (Season_2) during 2022-23, and were analyzed for nickel concentrations employing atomic absorption spectrophotometer. The mean concentrations of nickel were varied from 0.0125–0.0579 mg L− 1, 0.386–2.123 mg kg− 1, 0.00853–0.5784 mg kg− 1, 0.1085–0.5918 mg L− 1, 0.04664–0.2122 mg kg− 1, and 0.00820–0.2147 mg L− 1 in water, soil, forages, blood, feces, and milk, correspondingly. Highly significantly a negative correlation was observed among the soil vs fodder of Site_1 and Site_2 during both seasons. In animals, the highest nickel concentration was detected in blood of buffaloes at Site_1, while lowest in milk of cows at Site_2. Nickel concentrations were detected under standard permissible limits described by FAO/WHO. Except to BCF and EF, all the computed indices (PLI, Igeo, Eri, DIM, EDI, HRI, THQ, EDD, ECR, and ILTCR) were < 1, indicating low concentrations of nickel in soil and fodder, thus ensuring the safety of local ruminants upon ingestion during both seasons at both sites. Henceforth, strongly advocate the regular surveillance of heavy metal concentrations in the pasture grass surrounding contaminated locations is necessary. Furthermore, we suggest implementing precautionary measures to mitigate unintentional exposures of both livestock and, consequently, human beings to the deleterious effects of metal toxicity.