bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological Seawater Desalination
Authors: O. Martínez Enrique 
Published: April 2024

More than two billion people worldwide lack access to safe, clean drinking water, and this number is likely to increase due to population growth and rapidly diminishing freshwater supplies. Current seawater desalination methods can effectively provide freshwater and meet the growing demand for this resource. However, they are becoming increasingly controversial owing to their adverse environmental impacts, including high energy consumption and generation of desalination brine. For millions of years, various species of organisms such as plants, microalgae, and bacteria have adapted to environments with variable salinity and have developed mechanisms to eliminate excess intracellular NaCl. This has encouraged scientists to study the possibility of using biological processes for seawater desalination. Biodesalination is an emerging technology for the selective removal of Na + and Cl − from salt water by various halophile organisms, such as macrophytes, microalgae, and cyanobacteria, with very low energy consumption. Microbial desalination cells that allow simultaneous desalination of water in conjunction with wastewater treatment are also included in this category. The direct use of living organisms such as halophile plants, microalgae, and bacteria to desalinate water appears to be a promising field. However, the development and practical applicability of these technologies depend on the living organisms selected for desalinating seawater.
The Presence of Small-Size Circulating Tumor Cells Predicts Worse Prognosis in Non–Small Cell Lung Cancer Patients
Authors: Sun Qianqian , Li Weiqing , Yang Donghua , Lin Peter Ping , Zhang Lina , Guo Huiqin 
Published: April 2024

Context.—
Most patients with non–small cell lung cancers (NSCLC) are diagnosed at advanced stages. The 5-year survival rate of patients with advanced lung cancer is less than 20%, which makes lung cancer the leading cause of cancer-related deaths worldwide.

Objective.—
To identify indicators that can predict the prognosis of lung cancer patients.

Design.—
To determine the correlation between circulating tumor cells (CTCs), circulating tumor-derived endothelial cells (CTECs), and their subtypes and the prognosis of patients with NSCLC, 80 patients with lung cancer were recruited and 48 patients who met the enrollment criteria were selected in this study. Peripheral blood was collected from the enrolled patients before any treatment and analyzed by the subtraction enrichment and immunostaining–fluorescence in situ hybridization technique to determine the correlation between CTCs and CTECs and lung cancer disease progression and to identify prognostic indicators.

Results.—
In all patients, the positive rate of CTCs was 100% and the positive rate of CTECs was 81.3%. Patients with advanced or lymph node metastases had a higher rate of small-size CTC positivity than those with early or no lymph node metastases. Large-size CTEC positivity was higher in patients with advanced NSCLC than in early-stage patients (P = .03). Patients with ≥1 small-size CTC had shorter progression-free survival, and it was an independent prognostic factor.

Conclusions.—
Small-size CTCs are a reliable prognostic indicator and a probable predictor of the severity of disease in NSCLC patients.
Jongo e Saúde Mental: a fala como expressão cultural sem fronteiras raciais
Authors: Silva Mazariolli Andréa , Vidigal de Paula Fraulein , Francisco Mazariolli João 
Published: April 2024

A ideia da escrita desse artigo surgiu a partir da disciplina PSC6064-1 Saúde Mental e Racismo: Práticas Interventivas no Âmbito da Psicologia e da Psicanálise, ministrada em nove universidades simultaneamente na modalidade on-line promovida pela ANPSINEP - Articulação Nacional de Psicólogas(os) Negras(os) e Pesquisadoras(es), com aulas semanais, síncronas, em um projeto coletivo de formação de redes nessa temática. Durante as aulas foram apresentados alguns assuntos e o que mais me interessou foi o tema que possibilitou abrir um espaço para estudantes negros nas universidades, abrangendo ao mesmo tempo acolhimento, socialização, cultura, criatividade, bem-estar e saúde mental: O Jongo. Trata-se de uma forma de expressão afro-brasileira que integra percussão de tambores, dança coletiva com muito ritmo e alegria em seus versos e movimentos. É praticado nas periferias urbanas e em algumas comunidades rurais do sudeste brasileiro. A partir dessa dança coletiva promoveremos uma reflexão à luz da teoria da psicanálise sobre os benefícios da expressão corporal e do canto, num espaço de falas, trajetórias culturais e vivências do cotidiano que poderão contribuir com a transmissão cultural em um espaço de trocas entre saberes do conhecimento imaterial.
The Effect of Applying an Interdisciplinary Approach in the Management of Patients with Temporomandibular Joint (TMJ) Disorders at Dr. M. Djamil General Hospital, Padang, Indonesia
Authors: Gunawan Gunawan , Edi Sahputra  
Published: April 2024

Introduction: Temporomandibular joint (TMJ) disorders are a common health problem with significant global prevalence. Effective management of TMJ requires an interdisciplinary approach involving various health professions, such as dentists, physiotherapists, and psychologists.
Methods: This study aims to evaluate the effect of applying an interdisciplinary approach in the management of patients with TMJ disorders at Dr. M. Djamil General Hospital, Padang, Indonesia. A retrospective cohort study was conducted on TMJ patients referred to an interdisciplinary team between 2018 - 2023. Patient data was collected from electronic medical records and analyzed to compare the outcomes of patients who received an interdisciplinary approach with those who received a traditional approach.
Results: The results showed that the application of an interdisciplinary approach in the management of TMJ patients at Dr. M. Djamil General Hospital, Padang, Indonesia was associated with significant improvements in patient symptoms, including pain, joint dysfunction, and quality of life. Patients who received an interdisciplinary approach also demonstrated higher levels of satisfaction with their care.
Conclusion: Implementation of an interdisciplinary approach in the management of TMJ patients at Dr. M. Djamil General Hospital, Padang, Indonesia was associated with significant improvements in patients' symptoms and their level of satisfaction with treatment. This approach is recommended for the management of TMJ patients in all clinical settings.
Propuesta de un perfil de competencias profesionales para el docente universitario en el campo de las Ciencias de la Salud
Authors: Diaz Contino Cindy Giselle , Gómez García Fernanda , Culcay Delgado Joshua , García Coello Adriana 
Published: April 2024

The contemporary context of teaching in the field of health requires an update and expansion of teachers' skills, in order to adapt to the new challenges that are emerging. The objective of this study is to propose a competency-based profile for university teachers in the field of Health Sciences. An exhaustive bibliographic review was carried out of information sources that directly addressed teaching competencies, health pedagogy, and current challenges in higher education in Health Sciences. From this, a proposal for a teaching profile was developed based on five basic and three specific competencies. It is determined that the comprehensive training of teachers in the area guarantees that students are equipped to face professional challenges, which also impacts the improvement of health care in the community.
El contexto contemporáneo de la enseñanza en el ámbito de la salud requiere una actualización y ampliación de las habilidades de los docentes, con el fin de adecuarse a los nuevos retos que están surgiendo. El objetivo del presente estudio es proponer un perfil basado en competencias para el docente universitario en el campo de las Ciencias de la Salud. Se realizó una revisión bibliográfica exhaustiva de fuentes de información que abordaban directamente las competencias docentes, la pedagogía en salud, y los retos actuales en la educación superior en Ciencias de la Salud. A partir de ello se elaboró una propuesta de perfil docente basado en cinco competencias básicas y tres específicas. Se determinó que la formación integral de docentes en el área garantiza que los estudiantes en estén equipados para afrontar los retos profesionales, lo cual además impacta en el mejoramiento de la atención sanitaria en la comunidad.
¿Como pueden aportar las Apple Vision Pro en cirugía plástica?
Authors: Sanchez-Martínez Diego , Padilla-Rojas Julián , Diaz-Chaker William 
Published: April 2024

Technological advances have marked a milestone in traditional educational methods. The Apple Vision Pro comes with immersive technology of the highest quality, leading us in a direction in which residents and specialists can interact in a safe space. These glasses allow to improve surgical techniques, carefully study the anatomy of patients, recreate complex clinical cases, make video calls with other colleagues in real time to clarify doubts and also guide diagnoses, procedures and treatments, among other functions. Making this device an academic tool with unlimited potential for training in plastic surgery and other areas of medicine.
Los avances tecnológicos han marcado un hito en los métodos de educación tradicionales. Las Apple Vision Pro trae consigo una tecnología inmersiva de la mejor calidad, que nos encamina en una dirección en la que residentes y especialistas pueden interactuar en un espacio seguro. Estas gafas permiten mejorar técnicas las quirúrgicas, estudiar minuciosamente la anatomía de los pacientes, recrear casos clínicos complejos, realizar videollamadas con otros colegas en tiempo real para aclarar dudas y también orientar diagnósticos, procedimientos y tratamientos, entre otras funciones. Convirtiendo este dispositivo una herramienta académica con un potencial sin límites para el entrenamiento en cirugía plástica y otras áreas de la medicina.
Aportes de las Humanidades en la formación del Médico Cirujano de la Universidad de Antofagasta
Authors: Torres Belma Alberto , Varas Varas Diego 
Published: April 2024

If the teaching of Medicine is a great challenge for any health professional, the challenge will be greater for a professional in charge of this and belonging to the area of the humanities. It is here where the discipline of Psychopedagogy gains strength, supporting both teachers and students, becoming a holistic support that, within the possibilities, positively influences both the professional and personal training of the future doctor.
Si la enseñanza de la Medicina supone un gran desafío para cualquier profesional de la salud, más grande será el desafío para un profesional encargado de esto y perteneciente al área de las humanidades. Es aquí donde la disciplina de la Psicopedagogía toma fuerza, apoyando tanto a docentes como a estudiantes, convirtiéndose en un apoyo holístico, que, dentro de las posibilidades, influya positivamente en la formación tanto profesional como personal del futuro Médico Cirujano.
Análisis del Comportamiento de Compras On Line de los Consumidores Generacionales: Baby Boomers, Generación X, Milenials Y Generación Z, En la Ciudad de Loja, Ecuador
Authors: Gutiérrez Ordóñez Janeth Soledad 
Published: April 2024

La investigación tiene como propósito, analizar el comportamiento de las compras on line de los consumidores generacionales Baby Boomers, generación X, Millenials y generación Z, caso Loja Ecuador, investigación que se realiza con un enfoque cuali-cuantitativo, mediante la aplicación de encuestas a 400 personas, que forman parte de estos grupos etarios, se encontró información primaria, para lo cual se planteó una hipótesis, misma que se validó con una prueba de chi cuadrado, en donde de determina las variables que inciden en el comportamiento de los consumidores al momento de comprar on line. Eeste estudio demuestra que las variables como: ingreso, servicio, métodos de pago, canales digitales, influencers, marca, y otros, demostró que los consumidores utilizan diferentes canales digitales y aplicaciones móviles para comprar bienes y servicios, también se conoció de los diferentes métodos de pago que utiliza el consumidor para cancelar sus pedidos en línea, entre los que se encuentran transferencias, tarjetas de crédito, tarjetas de débito, Paypal y otros. El estudio muestra que la mayoría de consumidores realizan compras en línea porque son más amigables con la tecnología y las consideran más cómodas y seguras.
Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration
Authors: Pera Edgar M , Nilsson-De Moura Josefine , Pomeshchik Yuriy , Roybon Laurent , Milas Ivana 
Published: April 2024

We previously showed that SerpinE2 and the serine protease HtrA1 modulate fibroblast growth factor (FGF) signaling in germ layer specification and head-to-tail development of Xenopus embryos. Here, we present an extracellular proteolytic mechanism involving this serpin-protease system in the developing neural crest (NC). Knockdown of SerpinE2 by injected antisense morpholino oligonucleotides did not affect the specification of NC progenitors but instead inhibited the migration of NC cells, causing defects in dorsal fin, melanocyte, and craniofacial cartilage formation. Similarly, overexpression of the HtrA1 protease impaired NC cell migration and the formation of NC-derived structures. The phenotype of SerpinE2 knockdown was overcome by concomitant downregulation of HtrA1, indicating that SerpinE2 stimulates NC migration by inhibiting endogenous HtrA1 activity. SerpinE2 binds to HtrA1, and the HtrA1 protease triggers degradation of the cell surface proteoglycan Syndecan-4 (Sdc4). Microinjection of Sdc4 mRNA partially rescued NC migration defects induced by both HtrA1 upregulation and SerpinE2 downregulation. These epistatic experiments suggest a proteolytic pathway by a double inhibition mechanism:SerpinE2 ┤HtrA1 protease ┤Syndecan-4 → NC cell migration.
Cost-Efficient Deployment Strategies: A Comparative Analysis of Feature Flagging Services and Blue/Green Deployments
Authors: Kumarasamy Somasundaram 
Published: April 2024

Aims: This study provides a detailed comparison of two leading feature flagging services, LaunchDarkly and ConfigCat, and also examines the cost-efficiency and operational implications of using Blue/Green deployment strategies. It seeks to aid stakeholders in understanding the trade-offs and benefits of each approach to make informed decisions based on project-specific needs, budget constraints, and developmental objectives.
Study Design: The study employs a comparative analysis framework, focusing on features, usability, scalability, architectural design, and the financial impacts of adopting feature flagging services versus Blue/Green deployment strategies.
Place and Duration of Study: The analysis was conducted over a period of two years, encompassing a broad range of software development environments and project scenarios to ensure comprehensive coverage and relevance.
Methodology: The methodology employed in this paper includes a detailed examination of LaunchDarkly and ConfigCat's service offerings, an evaluation of Blue/Green deployment strategies, and an analysis of cost-efficiency of each approach. The study synthesizes information from product documentation, user feedback, and performance metrics, alongside interviews with industry experts and case studies from diverse software development projects.
Results: The results highlight the nuanced differences between feature flagging services in terms of scalability, ease of use, and the suitability for various project sizes. LaunchDarkly emerges as optimized for large-scale, complex projects due to its extensive feature set and scalability, while ConfigCat is favored for its simplicity and ease of use in smaller projects. The analysis also uncovers the cost benefits of feature flagging over Blue/Green deployments, emphasizing the savings on infrastructure and operational expenses while offering dynamic feature management capabilities.
Conclusion: The study concludes that the choice between feature flagging services like LaunchDarkly and ConfigCat, and the utilization of Blue/Green deployment strategies, should be guided by specific project requirements, financial constraints, and desired operational efficiency. Feature flagging services provide a cost-effective, flexible solution for dynamic feature management, whereas Blue/Green deployments offer a straightforward, though potentially more resource-intensive, approach to minimizing deployment risks. This comparative analysis aims to assist stakeholders in selecting the most appropriate deployment strategy to meet their development goals efficiently.
Detailed Characterization of Contact Resistance, Gate‐Bias‐Dependent Field‐Effect Mobility, and Short‐Channel Effects with Microscale Elastomeric Single‐Crystal Field‐Effect Transistors
Authors: Reese Colin , Bao Zhenan 
Published: January 2009

AbstractThe organic field‐effect transistor (OFET) has proven itself invaluable as both the fundamental element in organic circuits and the primary tool for the characterization of novel organic electronic materials. Crucial to the success of the OFET in each of these venues is a working understanding of the device physics that manifest themselves in the form of electrical characteristics. As commercial applications shift to smaller device dimensions and structure/property relationships become more refined, the understanding of these phenomena become increasingly critical. Here, we employ high‐performance, elastomeric, photolithographically patterned single‐crystal field‐effect transistors as tools for the characterization of short‐channel effects and bias‐dependent parasitic contact resistance and field‐effect mobility. Redundant characterization of devices at multiple channel lengths under a single crystal allow the morphology‐free analysis of these effects, which is carried out in the context of a device model previously reported. The data show remarkable consistency with our model, yielding fresh insight into each of these phenomena, as well as confirming the utility of our FET design.
Numerical analysis of thermal and electrochemical phenomena for anode supported microtubular SOFC
Authors: Cui Daan , Cheng Mojie 
Published: January 2009

AbstractA 2D model considering momentum, heat/species transport and electrochemical phenomena, has been proposed for tubular solid oxide fuel cell. The model was validated using experimental polarization curves and the good agreement with the experimental data was attained. The temperature distributions show that temperature varies severely at the tube inlet than at the tube outlet. The heat generation and transfer mechanisms in electrodes, electrolyte and electrochemical reaction interface were investigated. The results show that the overall electrochemical reaction heat is produced at cathode/electrolyte interface, and a small portion of the heat is consumed at anode/electrolyte interface. The heat produced at cathode/electrolyte interface is about five times as much as that consumed at anode/electrolyte interface. Overwhelming part of the heat transfer between cell and outside occurs at cathode external surface. Most current flow goes into anode from a very small area where the current collectors locates. © 2009 American Institute of Chemical Engineers AIChE J, 2009
Genetic polymorphisms in the thioredoxin 2 (TXN2) gene and risk for spina bifida
Authors: Wen Shu , Lu Wei , Zhu Huiping , Yang Wei , Shaw Gary M. , Lammer Edward J. , Islam Ana , Finnell Richard H. 
Published: January 2009

AbstractTXN2 encodes human thioredoxin 2, a small redox protein important in cellular antioxidant defenses, as well as in the regulation of apoptosis. Txn2 knockout mice fail to complete neural tube closure by E10.5 and die in utero. We hypothesized that genetic variation in human TXN2 gene may alter the function of the encoded protein in a manner associated with an increased risk for neural tube defects (NTDs). A DNA re‐sequencing effort of the human TXN2 gene was taken. After a variation in the promoter was identified, the transcriptional activity of different alleles was investigated. The possible association between these variations and the risk of spina bifida was further evaluated in a subset of samples obtained from a large population‐based case‐control study in California in two different ethnicity groups, non‐Hispanic white and Hispanic white. We identified a novel promoter insertion polymorphism located 9 base pairs upstream of the transcription start site of exon 1(‐9 insertion). The GA, G and GGGA insertions were associated with a marked decrease of transcriptional activity when overexpressed in both U2‐OS (an osteosarcoma cell line) and 293 cells (derived from human embryonic kidney). Further analysis revealed that the GA insertion was associated with increased spina bifida risk for Hispanic whites. Our study revealed a novel Ins/Del polymorphism in the human TXN2 gene proximal promoter region that altered the transcriptional activity and is associated with spina bifida risk. This polymorphism may be a genetic modifier of spina bifida risk in this California population. © 2009 Wiley‐Liss, Inc.
Detection of 53 FBN1 mutations (41 novel and 12 recurrent) and genotype–phenotype correlations in 113 unrelated probands referred with Marfan syndrome, or a related fibrillinopathy
Authors: Turner C.L.S. , Emery H. , Collins A.L. , Howarth R.J. , Yearwood C.M. , Cross E. , Duncan P.J. , Bunyan D.J. , Harvey J.F. , Foulds N.C. 
Published: January 2009

AbstractMutations in the gene encoding fibrillin 1 (FBN1) cause Marfan syndrome (MFS), and related connective tissue disorders. The disease spectrum is wide and while many genotype–phenotype correlations have been reported, few have been consistent. In this study FBN1 was analyzed in 113 patients with MFS or Marfan‐like features. Fifty‐three mutations were identified in 52 individuals, 41 of which were novel. The mutations comprised 26 missense, 11 splice site, 7 frameshift, 6 nonsense, 1 in‐frame deletion, and 2 whole exon deletions. In common with previous studies, genotype–phenotype analysis showed that a FBN1 mutation was more likely to be identified in patients fulfilling Ghent criteria (P = 0.005) and in those who had ectopia lentis (EL) (P < 0.0001). Other previously reported genotype–phenotype correlations were also considered and a new inverse association between a mutation in exons 59–65, and EL emerged (P = 0.002). © 2009 Wiley‐Liss, Inc.
Anterior segment anomalies of the eye, growth retardation associated with hypoplastic pituitary gland and endocrine abnormalities: Jung syndrome or a new syndrome?
Authors: Al‐Gazali Lihadh , Shather Bedir , Kaplan Waleed , Algawi Kais , Ali Bassam R. 
Published: January 2009

AbstractWe report on two children from an inbred Arab family with anterior segment anomalies of the eyes, growth retardation, associated with small pituitary gland, and endocrine abnormalities. The features in the sibs in this report are similar to those described in Peters‐plus syndrome. However, small pituitary gland associated with growth hormone deficiency has not been reported in Peters‐plus syndrome. In addition, sequencing of the B3GALTL gene, the gene implicated in Peters‐plus syndrome did not reveal any mutation in the sibs reported here. The association of anterior segment anomalies of the eye, growth retardation, and endocrine problems has previously been described by Jung et al. in 1995. We suggest that the features in the children in this report could represent variable manifestation of this syndrome or previously not described syndrome. © 2009 Wiley‐Liss, Inc.