bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retroperitoneal surgery in patients with nonseminomatous testicular cancer and minimal residual tumor
Authors: Qvist Hanne , Fosså Sophie Dorothea , Ous Sigurd , Lien Hans H. , Stenwig Anna E. , Giercksky Karl‐Erik 
Published: February 2007

AbstractIn the period 1980–1991, 78 patients with advanced nonseminomatous testicular cancer underwent retroperitoneal lymphadenectomy for post‐chemotherapy residual masses <2 cm. To decrease the frequency of “dry ejaculation” in these patients with no or limited residual disease, the extent of dissection was reduced during the period, with bilateral dissections (49 cases, 1980–1986) being initially replaced by unilateral procedures (19 cases, 1983–1990) and subsequently by nerve‐sparing techniques (10 cases, 1990–1991). As expected, a higher total number of lymph nodes was found in the retroperitoneal specimens after bilateral (44 (13–100)) than after unilateral (21 (7–35)) and nerve‐sparing (18 (7–60)) procedures. The number of lymph nodes with pathological changes was low, with 3 (1–16) after bilateral, 2 (1–9) after unilateral, and 2 (1–4) after nerve‐sparing operations. Histological examination revealed only necrosis/fibrosis in 65% of the patients, elements of mature teratoma in 28%, and remnants of viable malignant tumor in 6%. There were no major postoperative complications. “Dry ejaculation” was reported by 84% of the patients with bilateral operations, but was generally avoided after the unilateral (16%) and nerve‐sparing (nil) procedures. After a mean follow‐up of 83 (5–138) months, 6 patients have developed a recurrence, only one of them primarily in the retroperitoneal space. It is concluded that in patients with minimal residual retroperitoneal tumor, postchemotherapy lymphadenectomy using a unilateral or nerve‐sparing technique seems to offer an effective therapeutic alternative with acceptable postoperative morbidity and preserved ejaculation. © 1992 Wiley‐Liss, Inc.
Malignant melanoma of the vulva: A clinicopathologic study of 18 cases
Authors: Piura Benjamin , Egan Mark , Lopes Alberto , Monaghan John M. 
Published: February 2007

AbstractIn a study of 18 patients diagnosed with vulvar malignant melanoma between 1975 and 1991, the effect of clinical and pathologic variables on the survival was evaluated. The overall 5‐year survival rate was 28.6%. In 14 cases the tumor was retrospectively microstaged with use of Breslow depth and Chung levels. International Federation of Gynecology and Obstetrics (FIGO) stage and Breslow depth did not correlate well with survival. Positivity of groin lymph nodes at initial surgery was associated with an insignificant worsening in survival. An inverse correlation, although statistically not significant, was demonstrated between advancing Chung levels and survival. It is concluded that since the data with respect to microstaging of vulvar malignant melanoma is, as yet, still limited, great caution should be used in electing less aggressive surgery than radical vulvectomy and bilateral groin lymphadenectomy for patients with early‐microstage localized disease. © 1992 Wiley‐Liss, Inc.
A comparison of the clinical characteristics of second primary and single primary sarcoma: A population based study
Authors: Robinson Eliezer , Bar‐Deroma Raquel , Rennert Gadi , Neugut Alfred I. 
Published: February 2007

AbstractThe clinical characteristics of 240 patients with sarcoma as a second metachronous primary neoplasm (SPN) were compared with those of 8,815 patients with sarcoma as a single tumor. The data were obtained from patients registered during the period 1973–1986 in the Surveillance, Epidemiology and End Results (SEER) Program in the United States. Seventy‐four of the 240 SPN patients had postirradiation sarcoma (PIS) while the other 153 patients developed the sarcoma as a second tumor in an area which was not exposed to prior radiotherapy (non‐PIS). The stage of disease at diagnosis was more advanced in patients with PIS than in those with single sarcomas but the difference did not reach statistical significance. Overall, in comparable clinical stage localized and regional disease there was no statistically significant difference in survival between PIS and non‐PIS sarcoma patients after adjusting for age. The survival of patients with localized or regionally advanced sarcoma as a second tumor was significantly worse than of those with single sarcomas with the same stage. There was no difference in survival between first or second sarcomas with metastatic disease. © 1992 Wiley‐Liss, Inc.
Effect of liposomal interleukin‐2 on ascites‐forming rat hepatoma
Authors: Konno Hiroyuki , Maruo Yuji , Matin A. F. , Tanaka Tatsuo , Nakamura Satoshi , Baba Shozo , Yamashita Akira , Tadakuma Takushi 
Published: February 2007

AbstractInterleukin‐2 was entrapped in liposomes (Lip‐IL‐2) and injected into rats. The intraperitoneal injection of Lip‐IL‐2 into rats bearing an ascites‐forming rat hepatoma (AH‐66) significantly increased the survival time when compared with rats administered free IL‐2 or saline‐containing liposomes. The number of peritoneal excudate cells (PEC) increased markedly after intraperitoneal injection of Lip‐IL‐2 and consisted mainly of macrophages. The level of tumor necrosis factor a (TNF‐α) and the intensity of free radicals increased in the ascites at 48 hrs after Lip‐IL‐2 administration, whereas TNF‐α was not detected and the intensity of free radicals did not increase after free IL‐2 administration. Our findings suggested that entrapment of IL‐2 into liposomes enhanced its potential for cancer therapy, presumably by activating macrophages to produce TNF‐α and free radicals. © 1992 Wiley‐Liss, Inc.
The value of nuclear morphometry in the management of patients with colorectal polyps that contain invasive adenocarcinoma
Authors: Mitmaker Benjamin , Kyzer Shlomo , Begin Louis R. , Gordon Philip H. 
Published: February 2007

AbstractHaggitt's classification is a useful guide in the management of patients with large bowel polyps which contain invasive adenocarcinoma in that patients with levels 1 to 3 require no operation. Nuclear morphometry has been shown to be a useful prognostic discriminant for patients with invasive carcinoma of the large bowel. The nuclear shape factor of 44 polyps with invasive carcinoma was studied to determine whether this parameter was of value to define those patients with Haggitt level 4 who should have a resection. The shape factor of 50 interphase nuclei was obtained through the use of image analysis by tracing the nuclear profiles as digitized on a video screen. The nuclear shape factor was defined as the degree of circularity of the nucleus, a perfect circle recorded as 1.0. Our previous experience showed a nuclear shape factor greater than 0.84 was associated with a poor outcome. The overall mean shape factor was 0.71 (0.59–0.85). There was a tendency for the patients with residual disease to have values in the upper range. Our findings suggest that nuclear morphometry fails to add any predictive information in this clinical situation. © 1992 Wiley‐Liss, Inc.
Late relapse and mortality in stage I large bowel cancer
Authors: Hill George J. , Ghosh Bimal C. 
Published: February 2007

AbstractThe outcome was determined for patients with Stage I cancers of the large bowel (colon, rectum, and anus) who were treated from 1982–1989. In 119 consecutive patients, the 5‐year survival was approximately 70% (72% by the absolute direct method; 67% by the actuarial life table method). Although the overall 5‐year survival was similar to numerous other published reports, it was disturbing to observe that 41 % of the living patients had relapsed. Furthermore, although 88/119 (67%) were alive at last report, 2–7 years after treatment, only 23 (19%) were believed to be free of cancer. We conclude that follow‐up for more than 5 years and the assessment of disease‐free survival are required to evaluate the outcome from Stage I large bowel cancer. © 1992 Wiley‐Liss, Inc.
Mullerian adenosarcoma of the uterus with sarcomatous overgrowth
Authors: Hallak Mordechai , Peipert Jeffrey F. , Heller Paul B. , Sedlacek Thomas V. , Schauer Gail M. 
Published: February 2007

AbstractA case of mullerian adenosarcoma of the uterus with sarcomatous overgrowth is described. The patient was also found to have bilateral polycystic ovaries. This 25 year‐old white female presented with irregular vaginal bleeding and was diagnosed as having mullerian adenosarcoma with sarcomatous overgrowth by dilatation, curettage, and biopsy. Total abdominal hysterectomy, bilateral salpingo‐oophorectomy with lymph node sampling were performed. © 1992 Wiley‐Liss, Inc.
Hepatic resection following systemic chemotherapy for metastatic colorectal carcinoma
Authors: Fowler Wyatt C. , Eisenberg Burton L. , Hoffman John P. 
Published: February 2007

AbstractIncreasingly effective systemic chemotherapy has improved responses in patients with previously unresectable colorectal hepatic metastases. In the future, response to chemotherapy may define a new population of patients that may benefit from hepatic resection. A retrospective review to determine the safety and effectiveness of potentially curative hepatic resection of metastatic. colorectal carcinoma after systemic chemotherapy identified 11 such patients with resections between July 1987 and October 1991. Five patients had unresectable disease confined to the liver, two had hepatic and limited extrahepatic metastases, two had hepatic recurrences after previous hepatic metastasectomy, and two had initially resectable liver metastases. These patients were resected after a mean of 8 months of systemic chemotherapy. Complications, usually minor, occurred in five patients (45%). There were no deaths. Three patients are disease free at 15, 18, and 31 months (mean 21) after hepatic resection. Eight patients have recurred with a median time to recurrence of 8 months. Five patients have subsequently died of recurrent disease. This study suggests that hepatic resection following systemic chemotherapy can be performed safely and may benefit selected patients. © 1992 Wiley‐Liss, Inc.
Malignant melanoma in a child with oculocutaneous albinism
Authors: Levine Edward A. , Ronan Salve G. , Shirali Swati S. , Gupta Tapas K. Das , Karakousis Constantine P. 
Published: February 2007

AbstractMalignant melanoma is extremely rare in patients with albinism. To date, in the English language literature, there have been only sixteen documented cases of malignant melanoma in albino patients. These cases include thirteen cutaneous, one oral, one ocular, and one anal; only one of these was in a child. Here, we present the case of the youngest known albino patient to have cutaneous malignant melanoma. © 1992 Wiley‐Liss, Inc.
Accurate specimen preparation and examination is mandatory to detect lymph nodes and avoid understaging in colorectal cancer
Authors: Crucitti Francesco , Doglietto Giovanni Battista , Bellantone Rocco , Sofo Luigi , Bossola Maurizio , Ratto Carlo , Nucera Paolo , Silvestri Evelina , Crucitti Antonio , Vecchio Fabio Maria , Dobelbower Ralph 
Published: February 2007

AbstractLymph node involvement in colorectal cancer, one of the most important prognostic factors, can be sometimes underestimated. In this study the authors report the results of two different techniques of specimen preparation and examination. In 240 patients (Group I), histologic examination was performed using a conventional procedure. In Group II (60 cases) the resected bowel and its mesentery were separately stretched, pinned on to a cork board, and fixed. The mesentery was divided according to node location (intermediate and principal) and evaluated by sight and palpation to identify lymph nodes. The bowel segment was divided from 5 cm proximally to 5 cm distally to the tumor every 10 mm in serial 3 mm slices. Three and 10 mm slices were then carefully examined by sight and palpation. Isolated lymph nodes embedded in groups (10‐12 per paraffin block) were stained and investigated for neoplastic involvement. The specimen examination procedure used in Group I1 resulted in identification of a higher number of lymph nodes (mean = 41.1) and nodal metastases (mean = 10) compared to the standard technique used in Group 1 (mean = 11.3 and 2.4, respectively—P < .05). The percentage of N+ cases also was increased in Group II (48.3%) when compared to that in Group I (30.4%; P < .05). The new technique is simple, inexpensive, and efficacious for the detection of lymphatic metastases in colorectal cancer. © 1992 Wiley‐Liss, Inc.
Proliferative activity in gastric cancer determined with cell cycle‐related monoclonal antibodies Ki‐67 and p105: Analysis by flow cytometry
Authors: Kimura Hironobu , Yonemura Yutaka , Miyazaki Itsuo 
Published: February 2007

AbstractThe proliferative activity of gastric cancer cells was determined by DNA flow cytometric (FCM) analysis and labeling rates of Ki‐67 and monoclonal antibodies and proliferation‐associated nuclear antigen (p105) au‐toantibodies in 28 patients with fresh human gastric cancer cells. By setting the cutoff line at the level as used in a negative control study without primary antibody in the same sample, the Ki‐67 and p105 labeling rates were calculated by the dual fluorescence analysis. A total of 43 experiments was performed on FCM analysis for each antigen: 28 with Ki‐67 and 15 with p105. The mean Ki‐67 labeling rate of gastric cancer cells was 45.1% (13.9‐76.3%). The Ki‐67 labeling rates were significantly higher for larger size tumor, peritoneal metastasis, and advanced clinical stage. A significant correlation was found between Ki‐67 labeling rate and p105 labeling rate (P < 0.05). Bivariate FCM may be an easy method for obtaining useful information of cell kinetics. © 1992 Wiley‐Liss, Inc.
Colorectal carcinoma in young patients
Authors: Marble Kimberly , Banerjee Saumitra , Greenwald Lori 
Published: February 2007

AbstractUtilizing Tumor Registry records dating from 1935 to 1988, 50 patients diagnosed with colorectal adenocarincoma at the age of 40 years or younger were retrospectively studied with respect to sex, race, family history, delay in diagnosis, primary tumor location, tumor differentiation, mucin production, stage at presentation, and the effect of these factors on 5‐year survival. This younger group of patients was compared to a computer‐generated, randomly selected group of 50 patients 40 years of age or older. There was no difference with respect to sex, racial distribution, family history, symptoms at presentation, or expediency of physician diagnosis between the two groups. Younger patients waited significantly longer to seek medical attention than did their older counterparts. However, those patients who delayed presentation had no higher incidence of advanced disease than those patients who presented earlier. Younger patients had a higher incidence of poorly differentiated, advanced, rightsided tumors. This is in contrast to a predominance of well‐differentiated, less advanced, rectosigmoid lesions in the older patients. There was no age‐related difference in the incidence of mucin‐producing tumors. Overall 5‐year survival was 75% in older patients, in contrast to only 51% in younger patients (P = 0.01). We conclude in this study that it is advanced stage at presentation that is the most significant prognostic indicator in patients of all ages. The high incidence of poorly differentiated, right‐sided tumors is responsible for the majority of young patients presenting with advanced disease, resulting in their poorer prognosis. © 1992 Wiley‐Liss, Inc.
Synergistic effects of intratumor administration of cis‐diamminedichloroplatinum(II) combined with local hyperthermia in melanoma bearing mice
Authors: Kitamura Kaoru , Kuwano Hiroyuki , Matsuda Hiroyuki , Toh Yasushi , Masuda Hidetaka , Sugimachi Keizo 
Published: February 2007

AbstractThe synergistic effect of local hyperthermia (LHT) with intratumor injection (i.t.) of cis‐diamminedichloroplatinum (II) (DDP) was studied using a rodent model with implanted B16 melanoma tumors. The hindfoot of the C57BL/6 mouse bearing the tumor was placed in a water bath at 42.5 ± 0.2°C (intratumor temperature was at 42.3 ± 0.1°C) for 30 minutes just after local (i.t.) or systemic (intraperitoneal;i.p.) administration of DDP (1‐3 mg/kg once in experiment I and 1‐3 mg/kg three times in experiment II). The tumor growth ratio (TGR) at 7 days after treatment in the group given DDP 3 mg/kg (i.t.) with LHT was 1.1 in experiment I and 0.5 in experiment II, and there was a statistically significant difference in both experiments compared to findings in other groups (P < 0.01). The mean survival time was 42.1 days in experiment I and 50.2 days in experiment II, with a significant difference in the latter (P < 0.001). Thus regional injection chemotherapy given concomitantly with local hyperthermia promotes the anticancer effects and improves the prognosis without either severe renal injury or the promotion of hematogenic metastasis. © 1992 Wiley‐Liss, Inc.
Biological monitoring of cancer chemoprevention
Authors: Pillai Radhakrishna , Garewal Harinder S. , Wood Steven , Watson Ronald R. 
Published: February 2007

AbstractA major limiting factor in the successful implementation of cancer chemoprevention trials has been the determination of endpoints to measure efficacy and success. The use of the ultimate goal of such trials, namely, cancer incidence, as an endpoint has serious feasibility problems, including the need for large numbers of participants, long follow‐up periods, and high costs. The application of biological markers as intermediate endpoints to reveal responses to chemopreventive agents within a short time and to act as surrogates for cancer is an attractive concept worthy of intense investigation. This study reviews some potential biological markers, including genetic, cellular, biochemical, and immunological, as well as their possible application to cancer chemoprevention. © 1992 Wiley‐Liss, Inc.
Surgical treatment of colon and rectum adenocarcinoma in elderly patients
Authors: Vivi Ayder A. , Lopes Ademar , Cavalcanti Silvio De F. , Rossi Benedito M. , Marques Lourdes A. 
Published: February 2007

AbstractThe results are presented of disease‐free interval and overall survival in 53 elderly patients with colon or rectum adenocarcinoma treated with curative surgery. The average age was 75.3 years (median = 75.0); 21 patients were male and 32 were female. Tumor location was as follows: rectum 18 (34%), sigmoid 17 (32.1%), right colon 14 (26.4%), and transverse colon 4 (7.5%) All patients were surgically treated following the classical patterns for tumor resection. After pathological examination, which included the histological grade differentiation, the disease stage was reevaluated following the pTNM system. Overall and disease‐free survival at 5 years, for all patients, independent of histological grade differentiation and disease stage, were 75.3% and 55.5%, respectively. Overall survival at 5 years for patients with grades I and II histological differentiation was 74.1% and 85.0%, respectively. None of the grade III patients (2 cases) survived more than I year. The 5 years disease‐free survival for patients with histological grade differentiation I and II was 56.8% and 60%, respectively. There was no statistically significant difference in overall survival for patients with stages SI, SII, and SIII, but the disease‐free survival at 5 years by stages was found to be significant with rates of 100%, 67.6%, and 22.6%. Postoperative mortality was 4 (7.5%). The postoperative mortality and survival rates obtained in this group of patients encourage us not to consider age as a limiting factor for curative surgical treatment. © 1992 Wiley‐Liss, Inc.
Management of long‐term postirradiation periclavicular complications
Authors: Wang Edward H. M. , Sekyi‐Otu Ato , O'Sullivan Brian , Bell Robert S. 
Published: February 2007

AbstractFour cases of periclavicular postirradiation sarcoma and two cases of clavicular osteoradionecrosis with pathologic fractures are reported. All six cases presented more than 10 years after irradiation for breast cancer (five) or nasopharyngeal carcinoma (one). A review of radiotherapy received showed that they were subjected to unconventional radiation schedules (hypofractionation or high dose per fraction treatment). An approach to diagnosis and management of periclavicular lesions arising long after therapeutic irradiation is presented and the unique problems encountered with periclavicular surgery are discussed. © 1992 Wiley‐Liss, Inc.
Experimental chemotherapy for xenograft cell lines of human bile duct and gall bladder cancers in nude mice
Authors: Tsubono Michihiko , Nio Yoshinori , Tseng Chen‐Chiu , Kawabata Kazuya , Masai Yoshikazu , Hayashi Hitoshi , Fukumoto Manabu , Tobe Takayoshi 
Published: February 2007

AbstractMost biliary tract cancers are advanced and inoperable when first diagnosed. Even if surgery can be performed, the postsurgical prognosis of these diseases is poor. In the present study, we investigated effective chemotherapies for a human bile duct cancer xenograft cell line (undifferentiated carcinoma, BDC‐SN) and a gall bladder cancer xenograft cell line (well‐differentiated adenocarcinoma, GBC‐GN), which were transplanted into nude mice. Eight anticancer agents (CDDP, 5‐FU, VDS, MMC, ADR, EPIR, CQ, and VP‐16) and their various combinations were evaluated at 2–4 times the clinical dose. When used singly, CDDP, 5‐FU, and VDS were effective against BDC‐SN, and only CDDP was effective against GBC‐GN. Among the various 2‐agent combinations, CDDP + 5‐FU was the most effective against both BDC‐SN and GBC‐GN. However, 3‐agent combinations consisting of CDDP + 5‐FU + another agent were less effective than the CDDP + 5‐FU double regimen and caused significant loss of weight as well as high mortality. These results suggest that CDDP + 5‐FU may be the most useful regimen against biliary tract cancers in clinical application. © 1992 Wiley‐Liss, Inc.
Bowel perforation due to metastatic lung cancer
Authors: Gitt Steven M. , Flint Patricia , Fredell C. Herbert , Schmitz Gerald L. 
Published: February 2007

AbstractLung cancer infrequently metastasizes to the bowel. When this occurs, the symptoms may vary from mild to emergent in nature. Three patients are presented illustrating the life threatening complications that may occur due to bowel metastases of lung carcinoma. A review of the literature reveals that only four of 24 reported patients have survived bowel perforation due to metastatic lung carcinoma. One of the three patients presented herein survived to be discharged home. Patients with known lung carcinoma who develop abdominal complaints should be investigated aggressively to prevent life‐threatening complications by early intervention. © 1992 Wiley‐Liss, Inc.
Prediction of operative mortality based on impairment of host defense systems in patients with esophageal cancer
Authors: Saito Takao , Shimoda Katsuhiro , Kinoshita Tadahiko , Shicemitsu Yuji , Miyahara Masaki , Kobayashi Michio , Shimaoka Akira 
Published: February 2007

AbstractTo determine whether operative risk based on impaired defense systems can be predicted, we examined 21 markers in 32 patients with esophageal cancer seen between 1983 and 1985 and related them to postoperative deaths. A discriminant analysis proved useful in determining whether the patient would be at risk of operative mortality, based on impaired defense systems. This model, the host defense index (HDI), was then used clinically to evaluate findings in 64 patients seen between 1986 and 1991. During this period, a change in policy for performing transthoracic esophagectomy on and perioperative care for patients with impaired defense systems was associated with a decrease in operative mortality. Thus, the HDI is beneficial to predict the risk of operative mortality based on impaired defense systems in patients with esophageal cancer. © 1993 Wiley‐Liss, Inc.