bluuebunny/crossref_metadata_2025_split huggingface dataset:
MINocyclinE to Reduce inflammation and blood‐brain barrier leakage in small Vessel diseAse (MINERVA): A phase II, randomized, double‐blind, placebo‐controlled experimental medicine trial
Authors: Brown Robin B. , Tozer Daniel J. , Loubière Laurence , Harshfield Eric L. , Hong Young T. , Fryer Tim D. , Williams Guy B. , Graves Martin J. , Aigbirhio Franklin I. , O'Brien John T. , Markus Hugh S. 
Published: April 2024

AbstractINTRODUCTIONCerebral small vessel disease (SVD) is a common cause of stroke/vascular dementia with few effective treatments. Neuroinflammation and increased blood‐brain barrier (BBB) permeability may influence pathogenesis. In rodent models, minocycline reduced inflammation/BBB permeability. We determined whether minocycline had a similar effect in patients with SVD.METHODSMINERVA was a single‐center, phase II, randomized, double‐blind, placebo‐controlled trial. Forty‐four participants with moderate‐to‐severe SVD took minocycline or placebo for 3 months. Co‐primary outcomes were microglial signal (determined using 11C‐PK11195 positron emission tomography) and BBB permeability (using dynamic contrast‐enhanced MRI).RESULTSForty‐four participants were recruited between September 2019 and June 2022. Minocycline had no effect on 11C‐PK11195 binding (relative risk [RR] 1.01, 95% confidence interval [CI] 0.98–1.04), or BBB permeability (RR 0.97, 95% CI 0.91–1.03). Serum inflammatory markers were not affected.DISCUSSION11C‐PK11195 binding and increased BBB permeability are present in SVD; minocycline did not reduce either process. Whether these pathophysiological mechanisms are disease‐causing remains unclear.INTERNATIONAL CLINICAL TRIALS REGISTRY PORTAL IDENTIFIERISRCTN15483452Highlights
We found focal areas of increased microglial signal and increased blood‐brain barrier permeability in patients with small vessel disease.
Minocycline treatment was not associated with a change in these processes measured using advanced neuroimaging.
Blood‐brain barrier permeability was dynamic but MRI‐derived measurements correlated well with CSF/serum albumin ratio.
Advanced neuroimaging is a feasible outcome measure for mechanistic clinical trials.
Synthesis of diacylglycerol‐terminated lipid–polymer conjugates: Application to cell surface modification
Authors: Wang Wenjin , Zhou Chuanjiang , Guo Jiangping , Yu Yijia , Xia Wenjuan , Wu Zhaoqiang , Chen Hong 
Published: April 2024

AbstractWith the demand for the development of lipid–polymer conjugates (LPCs) for biomedical applications, the development of novel, rapid, and efficient methods for the synthesis of LPCs is of great significance. In this study, a novel Y‐type photoinitiator (Lipid‐PI) containing a diacylglycerol group was first synthesized, and then the polymerization of conjugated vinyl monomers such as oligoethylene glycol methyl ether methacrylate (OEGMA) and N,N‐dimethylacrylamide could be rapidly initiated by the Lipid‐PI initiator under Mn2(CO)10 and visible light radiation at room temperature to efficiently prepare LPCs. The 1H‐NMR results revealed that the diacylglycerol moiety resided at the terminal position of the LPCs molecular chain. Through dynamic light scattering and transmission electron microscopy techniques, it was found that the Lipid‐POF (POF is defined as poly(OEGMA‐co‐FluMA)) prepared from OEGMA monomers can self‐assemble into spherical micelles with a particle size of approximately 80 nm in pure water. Furthermore, the in vitro bioassay results illustrate that the prepared Lipid‐POF not only can successfully modify the L929 cell surface but also has good biocompatibility. Overall, this study not only provides a fast and efficient method for synthesizing LPCs but also has broad application potential in the biomedical field.
Preparation and properties of pale‐colored and optically transparent fluoro‐containing polyimide films with low solar absorptivity and enhanced high‐temperature dimensional stability for potential applications in space environments
Authors: Wang Zhenzhong , He Zhibin , Ren Xi , Zhang Yan , Wang Xiaolei , Yang Changxu , Han Shujun , Yu Haifeng , Liu Jin‐gang 
Published: April 2024

AbstractTwo organo‐soluble polyimide (PI) resins were prepared from a tricyclic fluoro‐containing dianhydride 9,9‐bis(trifluoromethyl)xanthene‐2,3,6,7‐tetracarboxylic dianhydride (6FCDA) and aromatic diamine of 2,2‐bis[4‐(4‐aminophenoxy)phenyl]hexafluoropropane (BDAF) for PI‐IIa and 1,3‐bis(3‐aminophenoxy)benzene (133APB) for PI‐IIb, respectively. For comparison, two analogous PIs were prepared from 4,4′‐(hexafluoroisopropylidene)diphthalic anhydride (6FDA) and the same diamines to afford PI‐Ia (6FDA‐BDAF) and PI‐Ib (6FDA‐133APB), respectively. Incorporation of the rigid and planar xanthene units in the 6FCDA‐PIs obviously decreased the solubility of the resins in organic solvents. Flexible and tough PI films were fabricated from the PI solutions in N,N‐dimethylacetamide (DMAc). The PI films derived from the rigid and planar 6FCDA dianhydride exhibited obviously enhance thermal stability, and high‐temperature dimensional stability. For example, PI‐IIa (6FCDA‐BDAF) showed the glass transition temperature (Tg) and coefficient of linear thermal expansion (CTE) values of 311.5°C and 50.5 × 10−6/K, respectively, which were all superior to those of the PI‐Ia counterpart (Tg = 264.6°C; CTE = 55.4 × 10−6/K). In addition, the 6FCDA‐PI films maintained the intrinsically excellent optical transparency of the fluoro‐containing PI films and showed the comparable optical properties to those of the 6FDA‐PI films. As for the properties highly related to the space applications, all the PI films exhibited low solar absorptivity (α) values of 0.18–0.20 and the good thermal emissivity (ε) values in the range of 0.68–0.70. PI‐Ia (6FDA‐BDAF) and PI‐IIa (6FCDA‐BDAF) films showed the similar atomic oxygen erosion behaviors with the standard Kapton® type of PI film derived from pyromellitic dianhydride (PMDA) and 4,4′‐oxydianiline (ODA).
Spirooxadiazoline‐oxindoles derived from imatinib show antimyeloproliferative potential in K562 cells
Authors: de Azevedo Liviane D. , Leite Debora I. , de Oliveira Andressa P. , Junior Floriano P. S. , Dantas Rafael F. , Bastos Monica M. , Boechat Nubia , Pimentel Luiz C. F. 
Published: April 2024

AbstractImatinib mesylate was the first representative BCR‐ABL1 tyrosine kinase inhibitor (TKI) class for the treatment of chronic myeloid leukemia. Despite the revolution promoted by TKIs in the treatment of this pathology, a resistance mechanism occurs against all BCR‐ABL1 inhibitors, necessitating a constant search for new therapeutic options. To develop new antimyeloproliferative substances, we applied a medicinal chemistry tool known as molecular hybridization to design 25 new substances. These compounds were synthesized and biologically evaluated against K562 cells, which express BCR‐ABL1, a constitutively active tyrosine kinase enzyme, as well as in WSS‐1 cells (healthy cells). The new compounds are conjugated hybrids that contain phenylamino‐pyrimidine‐pyridine (PAPP) and an isatin backbone, which are the main pharmacophoric fragments of imatinib and sunitinib, respectively. A spiro‐oxindole nucleus was used as a linker because it occurs in many compounds with antimyeloproliferative activity. Compounds 2a, 2b, 3c, 4c, and 4e showed promise, as they inhibited cell viability by between 45% and 61% at a concentration of 10 µM. The CC50 of the most active substances was determined to be within 0.8–9.8 µM.
Uranium Oxide Hydrate Frameworks with Dy(III) or Lu(III) Ions: Insights Into the Framework Structures With Lanthanide Ions
Authors: Zhang Yingjie , Lu Kimbal T. , Ablott Timothy A. , Zheng Rongkun 
Published: April 2024

AbstractTwo uranium oxide hydrate frameworks (UOHFs) with either Dy3+ or Lu3+ ions, Dy1.36(H2O)6[(UO2)10UO13(OH)4] (UOHF‐Dy) or Lu2(H2O)8[(UO2)10UO14(OH)3] (UOHF‐Lu), were synthesized hydrothermally and characterized with a range of structural and spectroscopic techniques. Although SEM‐EDS analysis confirmed the same atomic ratio of ~5.5 for U : Dy and U : Lu, they displayed different crystal morphologies, needles for UOHF‐Dy in the orthorhombic C2221 space group and plates for UOHF‐Lu in the triclinic P‐1 space group. Both frameworks are composed of β‐U3O8 type layers linked by pentagonal bipyramidal uranium polyhedra, with the Dy3+/Lu3+ ions inside the channels. However, the arrangements of Dy3+/Lu3+ ions are different, with disordered Dy3+ ions well aligned at the centers of the channels and single Lu3+ ions well‐separated in a zigzag pattern in the channels. While the characteristic vibrational modes were revealed by Raman spectroscopy, the presence of a pentavalent uranium center in UOHF‐Lu was confirmed with diffuse reflectance spectroscopy. The formation of two types of UOHFs with lanthanide ions, high or low symmetry, and the structure trend were discussed regards to synthesis conditions and lanthanide ionic radius. This work highlights the complex chemistry driving the formation of UOHFs with lanthanide ions and has implications to the spent nuclear fuel under geological disposal.
Square‐planar Tetranuclear Cluster‐based Alkaline Earth Metal–organic Frameworks with Enhanced Proton Conductivity
Authors: Wang Hui‐Pu , Liu Jin‐Cheng , Li Shu‐Fan , Meng Ya‐Ru , Zhang Gen , Su Jian 
Published: April 2024

AbstractAlkaline earth (AE) metal complexes have garnered significant interest in various functional fields due to their nontoxicity, low density, and low cost. However, there is a lack of systematic investigation into the structural characteristics and physical properties of AE‐metal‐organic frameworks (MOFs). In this research, we synthesized isostructural MOFs consisting of AE4(μ4‐Cl) clusters bridged by benzo‐(1,2;3,4;5,6)‐tris(thiophene‐2′‐carboxylic acid) (BTTC3−) ligands. The resulting structure forms a truncated octahedral cage denoted as [AE4(m4‐Cl)]6(BTTC)8, which further linked to a porous three‐dimensional framework. Among the investigated AE ions (Ca, Sr, and Ba), the Ca4‐MOF demonstrated good chemical stability in water compared to Sr4‐MOF and Ba4‐MOF. The N2 adsorption and solid‐state UV‐vis‐NIR absorption behaviors were evaluated for all AE4‐MOFs, showing similar trends among the different metal ions. Additionally, the proton conduction study revealed that the Ca4‐MOF exhibited ultra‐high proton conductivity, reaching 3.52×10−2 S cm−1 at 343 K and 98 % RH. Notably, the introduction of LiCl via guest exchange resulted in an improved proton conduction of up to 6.36×10−2 S cm−1 under similar conditions in the modified LiCl@Ca4‐MOF. The findings shed light on the regulation of physical properties and proton conductivity of AE‐MOFs, providing valuable insights for their potential applications in various fields.
In vitro antibacterial activity of antibiotics and plant essential oils against Escherichia coli MTCC443 supported through the molecular docking and pharmacokinetics study
Authors: Jain Saurabh , Shukla Adarsh Kumar , Panwar Surbhi , Kumar Rajesh , Kumar Ashwani 
Published: April 2024

AbstractMost of the Escherichia coli turned into serious pathogens or developed antibiotic resistance, mainly due to their ability to show different phenotypic traits. In order to overcome the resistance to these antibiotics, the use of essential oils (EOs) is of great significance against highly pathogenic microorganisms. This study has been made to compare the in vitro antibacterial activity and further validated the same through the molecular docking study of 13 antibiotics such as ciprofloxacin, chloramphenicol, erythromycin, ampicillin, cefotaxime, rifampicin, kanamycin, vancomycin, streptomycin, penicillin, nalidixic acid, trimethoprim, and polymyxin, and 10 EOs such as garlic, tulsi, neem, clove, thyme, peppermint, coriander, tea, lavender, and eucalyptus against the target protein (DNA gyrase) of E. coli MTCC443. E. coli Microbial Type Culture Collection 443 was found to be highly sensitive to ciprofloxacin (zone of inhibition [ZOI], 2.5 cm ±0.1) and chloramphenicol (ZOI, 1.8 cm ±0.1), whereas garlic oil (ZOI, 5.5 cm ±0.1) and coriander oil (ZOI, 4.4 cm ±0.1) were found comparatively most effective. Further, the in silico investigation observed the same; ciprofloxacin (binding affinity: −7.2 kcal/mol) and chloramphenicol (binding affinity: −6.6 kcal/mol). Penicillin (binding affinity: −4.2 kcal/mol) and polymyxin (binding affinity: −0.3 kcal/mol) were found to be least effective against the tested microbe, whereas vancomycin (binding affinity: +0.8 kcal/mol) had no effect on it. Garlic (binding affinity: −7.8 kcal/mol), coriander (binding affinity: −6.8 kcal/mol), peppermint (binding affinity: −6.2 kcal/mol), and neem (binding affinity: −6.2 kcal/mol) oil exhibited the potent antibacterial activity against E. coli MTCC443, whereas thyme (binding affinity: −6.1 kcal/mol), tea tree (binding affinity: −4.9 kcal/mol), and tulsi (binding affinity: −3.8 kcal/mol) oil were observed moderately effective. Eucalyptus (binding affinity: −2.9 kcal/mol) and lavender (binding affinity: −2.8 kcal/mol) oil were found to be the least effective among all the oils tested. The pharmacokinetics and networking were performed to the pharmacology of the potential compounds.
Kombinierte Kapillartransportfunktion für Saugen und Weiterverteilen
Authors: Krus Martin , Peuser Michael Thomas 
Published: April 2024

AbstractMit der Software‐Familie WUFI und ihrer weltweit hohen Anzahl von Anwendern wurde ein validiertes hygrothermisches Simulationssystem entwickelt. Insbesondere die Verwendung unterschiedlicher Feuchtetransportkoeffizienten für Saugen und Weiterverteilen hat einen großen Einfluss auf die Berechnungsergebnisse. Um den Aufwand zu begrenzen, wird derzeit ein einfacher Ansatz gewählt. Immer wenn die Fassade befeuchtet ist, werden die Transportkoeffizienten für das Saugen für die gesamte Konstruktion und ohne Befeuchtung die für das Weiterverteilen verwendet. Da die Regenzeiten in Deutschland weniger als 4 % ausmachen, ergibt sich daraus in der Regel nur ein relativ kleiner Fehler. Dies ändert sich, wenn Berechnungen für Regionen mit deutlich höheren Niederschlagszeiten durchgeführt werden. Unser Ansatz besteht in einer einzigen Kapillartransportfunktion, bei der die Transportkoeffizienten im unteren Feuchtebereich denen der Weiterverteilung entsprechen und im oberen Bereich an das kapillare Aufnahmevermögen (hauptsächlich über den w‐Wert) angepasst sind. Die Eignung dieses Ansatzes wurde anhand eindimensionaler hygrothermischer Berechnungen für verschiedene Wandkonstruktionen und unterschiedliche Innen‐ und Außenklimate untersucht und bewertet. Es konnte gezeigt werden, dass dieser Ansatz im Allgemeinen eine gute Übereinstimmung mit den Ergebnissen des bisherigen Ansatzes aufweist. Außerdem erfolgte zusätzlich eine Validierung mit Messergebnissen aus einer Freilanduntersuchung.
Einfach Bauen und Schallschutz – ein Konflikt?
Authors: Niemann Anne , Schanda Ulrich 
Published: April 2024

AbstractIn der Diskussion um bezahlbares Bauen werden aktuell die Standards im Wohnungsbau hinterfragt, darunter auch die Schallschutzanforderungen. Die Wahrnehmung von Schallschutz ist subjektiv und wird von verschiedenen Faktoren wie Alter und individuellen Empfindlichkeiten beeinflusst. Nachbarschaftslärm kann zu Schlafstörungen und Belästigungen führen, während Verkehrslärm nachweislich Gesundheitsprobleme verursacht. Das Konzept „Einfach Bauen“ zielt darauf ab, das Bauen zu vereinfachen und nachhaltiger zu gestalten. Drei Forschungshäuser, die diesem Konzept folgen, wurden auf Schallschutz überprüft. Dabei erfüllten Wohnungstrennwände und ‐decken die Anforderungen. Die Untersuchung der Bewohnerzufriedenheit durch Befragungen in diesen Häusern zeigt, dass die Wahrnehmung von Lärm stark variiert. Die Zufriedenheit wird durch die Kommunikation mit den Nachbarn beeinflusst. Das Fallbeispiel verdeutlicht, dass Schallschutzanforderungen oft nicht den individuellen Lärmempfinden gerecht werden, da nicht‐akustische Faktoren eine starke Rolle spielen. Die Erwartung eines reduzierten Schallschutzes bei „Einfach Bauen“ kann zu Fehlvorstellungen führen, wie der Auszug von Bewohnern aus Schallschutzgründen zeigt. Die derzeitigen Mindestanforderungen an den Schallschutz erweisen sich für sehr empfindsame Menschen als unzureichend. Es ist wichtig, dass die Bewohner über den zu erwartenden Schallschutz informiert werden, um ein harmonisches Zusammenleben zu ermöglichen.
Data‐Driven Design of NASICON‐Type Electrodes Using Graph‐Based Neural Networks
Authors: Shim Yoonsu , Jeong Incheol , Hur Junpyo , Jeen Hyoungjeen , Myung Seung‐Taek , Lee Kang Taek , Hong Seungbum , Yuk Jong Min , Lee Chan‐Woo 
Published: April 2024

AbstractSodium superionic conductor (NASICON)‐type cathode materials are considered promising candidates for high‐performance sodium‐ion batteries (SIBs) because of the abundance and low cost of raw materials. However, NASICON‐type cathodes suffer from low capacities. This limitation can be addressed through the activation of sodium‐excess phases, which can enhance capacities up to theoretical values. Thus, this paper proposes the use of transition metal (TM)‐substituted Na3V2(PO4)2F3 (NVPF) to induce sodium‐excess phases. To identify suitable doping elements, an inverse design approach is developed, combining machine learning prediction and density functional theory (DFT) calculations. Graph‐based neural networks are used to predict two crucial properties, i. e., the structural stability and voltage level. Results indicate that the use of TM‐substituted NVPF materials leads to about 150 % capacity enhancement with reduced time and resource requirements compared with the direct design approach. Furthermore, DFT calculations confirm improvements in cyclability, electronic conductivity, and chemical stability. The proposed approach is expected to accelerate the discovery of superior materials for battery electrodes.
Evolution of dynamic capabilities for business sustainability performance: Evidence from the Indian manufacturing sector
Authors: Bhadra K. V. , Kamalanabhan T. J. , Singh Sanjay Kumar 
Published: April 2024

AbstractFirms can achieve trinomial sustainability goals if they can constantly build and rejuvenate their capabilities to adapt to new situations. However, few studies consider the interrelationships between the distinct capabilities pertinent to sustainable development and the impact of these capabilities on firm performance under diverse contexts, especially in emerging economies. Drawing on dynamic capability theory, we developed a model to test the links between dynamic sustainability capability, theorized as a higher order capability, and relational and managerial capabilities, theorized as lower order capabilities, to the firm's sustainability performance. Data collected from 210 large Indian manufacturing firms is analyzed using PLS‐SEM. Results confirm that dynamic sustainability capability has facilitating effects on environmental and social performance directly and indirectly through managerial capability. Although relational capability partially mediates the link between dynamic sustainability capability and social performance, it does not impact environmental performance. Further, the aforementioned relationships are affected by forces in the firms' environment. Most of the direct and indirect relationships are negatively moderated by organizational inertia and positively moderated by environmental turbulence. By investigating the hierarchically structured capabilities, this study guides firms to make strategic choices regarding resource calibration for sustainability. The study recommends that organizations looking to integrate dynamic sustainability capability as part of their strategic management should look at the sequential combinations of existing resources to achieve different sustainability targets. The study's findings also urge policymakers to consider environmental conditions while developing sustainability reforms.
Dissolved gases from pressure changes in the lungs elicit an immune response in human peripheral blood
Authors: Harrell Abigail G. , Thom Stephen R. , Shields C. Wyatt 
Published: April 2024

AbstractConventional dogma suggests that decompression sickness (DCS) is caused by nitrogen bubble nucleation in the blood vessels and/or tissues; however, the abundance of bubbles does not correlate with DCS severity. Since immune cells respond to chemical and environmental cues, we hypothesized that the elevated partial pressures of dissolved gases drive aberrant immune cell phenotypes in the alveolar vasculature. To test this hypothesis, we measured immune responses within human lung‐on‐a‐chip devices established with primary alveolar cells and microvascular cells. Devices were pressurized to 1.0 or 3.5 atm and surrounded by normal alveolar air or oxygen‐reduced air. Phenotyping of neutrophils, monocytes, and dendritic cells as well as multiplexed ELISA revealed that immune responses occur within 1 h and that normal alveolar air (i.e., hyperbaric oxygen and nitrogen) confer greater immune activation. This work strongly suggests innate immune cell reactions initiated at elevated partial pressures contribute to the etiology of DCS.
Aortic root morphometry revisited—Clinical implications for aortic valve interventions
Authors: Dudkiewicz Damian , Lis Maciej , Yakovliev Artem , Hołda Jakub , Bolechała Filip , Strona Marcin , Kopacz Paweł , Hołda Mateusz K. 
Published: April 2024

AbstractThe complex anatomy of the aortic root is of great importance for many surgical and transcatheter cardiac procedures. Therefore, the aim of this study was to provide a comprehensive morphological description of the nondiseased aortic root. We morphometrically examined 200 autopsied human adult hearts (22.0% females, 47.9 ± 17.7 years). A meticulous macroscopic analysis of aortic root anatomy was performed. The largest cross‐section area of the aortic root was observed in coaptation center plane (653.9 ± 196.5 mm2), followed by tubular plane (427.7 ± 168.0 mm2) and basal ring (362.7 ± 159.1 mm2) (p < 0.001). The right coronary sinus was the largest (area: 234.3 ± 85.0 mm2), followed by noncoronary sinus (218.7 ± 74.8 mm2) and left coronary sinus (201.2 ± 78.08 mm2). The noncoronary sinus was the deepest, followed by right and left coronary sinus (16.4 ± 3.2 vs. 15.9 ± 3.1 vs. 14.9 ± 2.9 mm, p < 0.001). In 68.5% of hearts, the coaptation center was located near the aortic geometric center. The left coronary ostium was located 15.6 ± 3.8 mm above sinus bottom (within the sinus in 91.5% and above sinutubular junction in 8.5%), while for right coronary ostium, it was 16.2 ± 3.5 mm above (83.5% within sinus and 16.5% above). In general, males exhibited larger aortic valve dimensions than females. A multiple forward stepwise regression model showed that anthropometric variables might predict the size of coaptation center plane (age, sex, and heart weight; R2 = 31.8%), tubular plane (age and sex; R2 = 25.6%), and basal ring (age and sex; R2 = 16.9%). In conclusion, this study presents a comprehensive analysis of aortic‐root morphometry and provides a platform for further research into the intricate interplay between structure and function of the aortic root.