bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequential and adjuvant chemotherapy for malignant astrocytoma of the brain
Authors: Kessinger Anne , Lemon Henry M. , Foley John F. 
Published: February 2007

AbstractTwenty‐nine patients with grade III or IV astrocytomas were treated with 1,3 bis(2‐chloroethyl)‐1‐nitrosourea (BCNU), 75–100 mg/M2 intravenously (IV) for two consecutive days every four to six weeks, in an effort to improve the quality and length of their survival following surgical resection. Twenty‐one of these patients received adjunctive chemotherapy as soon as they recovered from surgery and 18 received concomitant adjunctive radiation therapy as well. Eight patients were treated with radiation therapy after surgery, and BCNU was not added until evidence of tumor growth appeared. BCNU was discontinued and the epipodophyllotoxin. VM‐26, was given at a dose of 100 mg/M2 IV weekly when further tumor growth occurred. Patients receiving adjuvant chemotherapy had a shorter mean and median survival than patients receiving BCNU when progression appeared following radiation therapy. Six patients with progressive disease following surgical resection and radiation therapy for grade 11 astrocytoma were treated with BCNU. Improvement or stabilization of neurologic symptoms occurred in four of these patients. This trial of lower‐dose BCNU therapy produced survival rates similar to higher‐dose studies and permitted fewer physician visits by the patient.
Recurrent breast cancer: Factors influencing survival, including treatment
Authors: Pearlman N. W. , Jochimsen P. R. 
Published: February 2007

AbstractFactors influencing survival were reviewed in 464 patients with recurrent breast cancer. Site of first recurrence and rate of tumor progression governed prognosis more than choice of initial therapy. Overall median survival was 22—26 months for bone/soft‐tissue disease, 10—12 months for pleura/lung, and 4—6 months for liver/brain recurrence. Patients with slow rates of tumor progression at each site had longer survival terms than did rapid progressors. About 50% of patients with bone or soft‐tissue recurrence had slow progression and long survival, regardless of whether initial treatment was local or systemic. In visceral recurrence, the number of patients with slow progression was doubled with systemic therapy in comparison to local treatment (from 16—20% for the latter to 37—38% for the former). In addition, long‐term survival in patients with similar progression rates was best using initial systemic therapy.
Tumor cell karyotypes in malignant melanoma
Authors: Henry W. M. , Didolkar M. S. , Lopez R. , Tomei L. D. 
Published: February 2007

AbstractFifteen malignant melanomas were subjected to chromosomal analysis, in order to determine whether the number of chromosomes in a tumor cell could be correlated to a clinical prognosis. The protocol involved a direct technique which utilized a Colcemid blockade of spindle formation in mitosis to allow study of metaphase chromosomes. The direct method was chosen to reveal chromosome changes in the tumor cell in situ rather than changes in the cultured cell. Two tumors yielded chromosome spreads which could be counted and correlated with a clinical prognosis. Failure to obtain other adequate chromosome spreads were accounted for by the presence of tissue necrosis and the absence of viable tumor cells.
Multiple carcinomas following therapy for Hodgkin disease
Authors: Mullen James L. , Reichman Joseph , Rosato Ernest F. 
Published: February 2007

AbstractA 52‐year‐old man developed synchronous squamous‐cell carcinoma of the larynx and middle one‐third of the esophagus following treatment for Hodgkin disease. This patient fell into the subgroup of patients treated by intensive radiation therapy followed by intensive chemotherapy. The link between the therapy and subsequent carcinoma is suggestive. Long‐term follow‐up care of patients with Hodgkin disease demands continuing evaluation for this possible complication.
Serum immunoglobulins in breast cancer
Authors: Alsabti ELIAS A. K. 
Published: February 2007

AbstractEighty‐one women admitted for breast tumor biopsy have been followed sequentially for 12 months. Thirty‐one women had clinical stage I and II breast cancer and 50 had benign breast disease. All these women had serum immunoglobulin IgA, IgC, IgM and IgE levels measured by immunodiffusion and radioimmunoassay preoperatively, two weeks postoperatively, then three months, six months, nine months and twelve months postoperatively. Significant differences were found in IgA and IgG levels preoperatively in the cancer group while no differences were found in IgM or IgE levels at any time. There was positive correlation between the extent of metastatic breast cancer and IgA level. There was negative correlation between the extent of metastatic breast cancer and IgM levels. These findings raise the value of measuring the levels of immunoglobulins in patients with breast cancer as a guide to subclinical spread of the disease. The results may also support the hypothesis of the role of early immune defect in immunoglobulin metabolism in the pathogenesis of breast cancer.
Pseudo‐chondrosarcoma: Solitary osseous metastases from atypical bronchogenic carcinoma
Authors: Lokich Jacob J. , Bailey Harry , Bud Dixon D. , Starkey George 
Published: February 2007

AbstractA patient with bronchogenic carcinoma with a solitary metastases to the femur in whom the clinical, radiologic, and pathologic setting suggested that the primary tumor was the bone lesion (chondrosarcoma) and the pulmonary lesion was a solitary metastasis is presented. This case is added to the limited literature indicating that mucin‐secreting tumors metastatic to bone may simulate primary bone tumors radiographically.
Reductive surgery of unresectable lung cancer: A case report
Authors: Takita H. 
Published: February 2007

AbstractThe only effective therapy for non‐small‐cell lung cancers has been surgical resection. In the present study a patient with unresectable adenocarcinoma of the lung was treated by chemoimmunotherapy and surgery, and has been doing well for 19 months following surgery. The case is presented as an example of treatment of advanced lung cancer by combined modality approach.
Fibroxanthosarcoma of the head and neck
Authors: McColl Harry A. , Moore Gene H. 
Published: February 2007

AbstractFibroxanthosarcoma is a variant of malignant fibrous histiocytoma probably derived from the primitive tissue histiocyte. It occurs rarely in the head and neck. This lesion may be confused with the benign atypical fibroxanthoma. However, newer histologic criteria may allow definitive differential diagnosis which is important because of the aggressive biologic behavior of fibroxan‐ thosarcoma. Aggressive initial surgery with a consideration of regional lympha‐ denopathy offers the best chance for cure.
Production and secretion of proteolytic enzymes by normal and neoplastic cells
Authors: Barry Boyd J. , Farb Roderick M. , Yost Fred J. , Georgiade Nicholas , Lazarus Gerald S. 
Published: February 2007

AbstractA possible mechanism for tumor cell invasion of normal tissue might be secretion of proteolytic enzymes. This study compares and contrasts production and secretion of proteinases by cell cultures of normal and chemically transformed mouse epithelial cells. Lysates of normal and neoplastic cells contain similar amounts of neutral proteinase, cathepsin D and plasminogen activator. Neither collagenase nor elastase could be identified in lysates of, or serumfree culture medium bathing, normal or neoplastic cells. Neoplastic cells secrete ten times more plasminogen activator than normal cells. Our data support the hypothesis that plasminogen activator produced by neoplastic cells could function to activate latent proteolytic enzymes secreted by connective tissue cells which might result in spread of neoplastic cells into normal tissue.
Umbilical metastasis as the presenting symptom of cecal carcinoma
Authors: Jager Rama M. , Max Martin H. 
Published: February 2007

AbstractUmbilical metastases were encountered as the initial presentation of cecal adenocarcinoma in a 62‐year‐old woman. Intravenous infusion of 5‐fluorouracil, along with intralesional injections of 10% 5‐fluorouracil, resulted in regression of the tumor masses on the abdominal wall. Although umbilical metastasis is rare, its significance in diagnosing an otherwise silent colorectal cancer warrants the physician's awareness.
Randomized study of control of the primary tumor and survival using preoperative radiation, radiation alone, or surgery alone in head and neck carcinomas
Authors: Hintz Brace , Charyulu Komanduri , Chandler James R. , Sudarsanam Anam , Garciga Carlos 
Published: February 2007

AbstractFifty‐five selected patients with previously untreated squamous cell carcinoma of the head and neck regions were studied in a randomized, prospective manner. The three treatment categories were primary radiation (Gp R), primary surgery (Gp S), and preoperative radiation of 4000 rads in four weeks (Gp R/S). The local control rates for the 44 evaluable patients with a two‐year minimum followup were 24%, 39%, and 43% respectively. Further treatment attempts in patients failing initial therapy yielded local control rates of 35%, 39%, and 43% for Gp R, Gp S, and Gp R/S, respectively. None of the local control rates nor the corresponding survival curves were significantly different at P < 0.10. However, the group sizes were sufficiently small that true differences might not have been detected. Postoperative complications were higher in the primary radiation failures subsequently operated upon compared to the primary surgery group (P = 0.07).
Zinc and copper levels in whole blood and plasma from patients with squamous cell carcinomas of head and neck
Authors: Abdulla M. , Biorklund A. , Mathur A. , Wallenius K. 
Published: February 2007

AbstractZinc in plasma and whole blood from 13 patients with squamous cell carcinoma of the head and neck was significantly decreased, and the copper:zinc ratio in the plasma was significantly higher than in healthy controls.The plasma zinc was significantly lower in patients who did not respond to therapy and who died within 12 months than in those who responded to therapy and had a remission within 12–15 months. In patients responding to therapy and alive after 12–15 months, zinc in the plasma and whole blood and the copper:zinc ratio became normal.These results suggest a potential screening and predicting value of zinc in the plasma and whole blood and the copper:zinc ratio in squamous cell carcinoma of the head and neck.
Anaplastic Carcinoma of the Thyroid in a Population Irradiated for Hodgkin Disease, 1910–1960
Authors: Gétaz E. Paul , Shimaoka Katsutaro 
Published: February 2007

AbstractPost‐irradiation carcinoma of the thyroid is usually histologically well‐differentiated. In general, those subjects who developed carcinoma had been exposed to low‐to‐moderate doses of irradiation for benign conditions. We reviewed the charts of 520 patients with Hodgkin's disease seen at Roswell Park Memorial Institute, and found 2 cases of anaplastic carcinoma amongst other thyroidal abnormalities. The existing reports of post‐irradiation carcinoma are reviewed and suggestions are made for the management of heavily irradiated, potentially cured patients with Hodgkin's disease.
A new approach in the immunotherapy of carcinoma of the colon and rectum
Authors: Wallack Marc K. 
Published: February 2007

AbstractAlthough the therapy of carcinoma of the colon and rectum has been investigated, little progress has been made in prolonging the survival in these patients. Specific active immunotherapy may provide the answer. Previous investigators have shown that colorectal cancer elicits an immune response and may be susceptible to immunologic manipulation. My laboratory has shown that a live vaccinia virus‐augmented (vaccinia oncolysate) tumor cell vaccine is safe and may be worthwhile in the surgical adjuvant treatment of colorectal cancer. Nine patients with advanced cancer were treated. 0/9 showed adverse effect and 3/9 showed lack of progression of disease. Randomized prospective trials are now underway.
Sarcoma of the stomach: Clinicopathologic study of 43 cases
Authors: Bedikian Agop Y. , Khankhanian Nayereh , Valdivieso Manuel , Heilbrun Lance K. , Benjamin Robert S. , Yap Boh‐Seng , Nelson Robert S. , Bodey Gerald P. 
Published: February 2007

AbstractThe records of 43 patients with histologically proved primary gastric sarcoma treated at M. D. Anderson Hospital and Tumor Institute between 1945 and 1975 were reviewed. Weight loss, abdominal pain, and hematemesis or melena were the most common symptoms, and palpable epigastric mass was the most common physical sign. Ninety‐five percent of the gastric tumors were leiomyosarcomas. The median survival time and the five‐year survival for the 29 patients who had curative gastrectomy were 33 months and 38%, respectively. Morphologic and histologic factors that adversely influenced the length of disease‐free interval and survival following curative surgery included 1) primary tumor 8 cm or greater in diameter, 2) tumor extension to serosa of the stomach, and 3) low grade of differentiation of the primary tumor. Seventy‐seven percent of recurrences in patients with curative tumor resection occurred within two years of resection of the primary. Of the 17 patients with advanced disease who received chemotherapy, two (15%) had objective tumor regression of greater than 50% and survived 16 and 24 months, compared with a median survival time of eight months for patients who failed to respond. New approaches that may improve the results of treatment of gastric sarcoma are discussed.
Cellular immune deficiency in black patients with basal cell carcinoma
Authors: Burns Janis E. , Eisenhauer Emily D. , Jabaley Michael E. , Cruse Julius M. 
Published: February 2007

AbstractSkin cancer, the most common malignancy in white patients, is rare in black populations. Seventeen black patients have been diagnosed and treated for basal cell carcinoma in the past 20 years at the University of Mississippi Medical Center. Ten of them have died, six of various types of cancer. Of the seven living patients, one had two cancers at the time of study: a new basal cell carcinoma and generalized lymphoma. The majority of patients had some degree of mixed racial ancestry, with medium to light brown skin, a history of heavy sun exposure, and lesions appearing on the head or neck. Highly significant depression of cellular immunity was demonstrated in these patients by T‐cell assay. Altered tumor surveillance is implied as an etiological factor in basal cell carcinogenesis in black patients.
Colony stimulating activity in sera of erythroleukemic mice (RLV‐A)
Authors: Koltun L. , Lobue J. , Gordon A. S. , Fredrickson T. N. 
Published: February 2007

AbstractRLV‐A serum activity was measured by the agar colony assay to determine the effect of this erythroid dyscrasia on the granulopoietic humoral regulator, colony stimulating factor (CSF).In general, the sera of early, midstage and terminal animals not given endotoxin had high cluster forming properties compared to normal sera. The sera of early, midstage, and terminal mice treated with endotoxin had only a fraction of the colony forming ability of serum obtained from normal endotoxin‐treated mice (EMS) with the earliest stages of the disease showing least activity followed by a rise in activity paralleling normal EMS, as the disease progressed. Sera from RLV‐A endotoxin treated mice retained ability to stimulate cluster growth especially when compared to the slight activity displayed by normal endotoxin treated mouse sera.
Liver scanning in newly diagnosed breast carcinoma
Authors: Haid Max , Singh Jaspal , Nevinny Hans B. 
Published: February 2007

AbstractThe records of 111 consecutive cases of carcinoma of the breast were reviewed and yielded 66 patients who had undergone liver scanning and determination of the serum alkaline phosphatase (alk p'tase), lactic dehydrogenase (LDH), and serum glutamic oxaloacetic transaminase (SGOT). Four of the 66 patients (6.1%) had a focal defect on the liver scan. Two of those two had normal enzymes and two had at least one enzyme elevation. The two with normal enzymes have enjoyed prolonged disease‐free survivals. The two with an elevated enzyme have both expired due to metastatic disease. No correlation could be found between the number of involved axillazry nodes at surgery and the risk of having a focal defect on the liver scan. This study suggests that routine radionuclide liver scanning in the perimastectomy period does not add useful information in the face of normal alk p'tase, LDH, and SGOT.
Granular cell tumor: A clinicopathologic study of 110 patients
Authors: Lack Ernest E. , Worsham R. G. Frederick , Callihan Michael D. , Crawford Benton E. , Klappenbach Scott , Rowden Geoffrey , Chun Byungkyu 
Published: February 2007

AbstractThe clinicopathologic features of 118 granular cell tumors (GCT) encountered at two affiliated hospitals were reviewed. A total of 110 patients were affected over this 32‐year period of study (71 men, 39 women), and in 5% GCT were multiple. Patients ranged in age from 16 to 58 years (average 32 years) and were symptomatic for an average duration of 11 months prior to diagnosis. There was a greater than expected frequency of GCT among black patients (29%). Although tongue was the single most common anatomic site involved, relatively more GCT (44%) occurred in skin or subcutaneous tissue. Less common locations were breast parenchyma (10 cases), rectal mucosa and anus (6), vulva (4), esophagus and larynx (2 cases each). The correct preoperative diagnosis of this protean tumor was made in only three patients. GCT were surgically treated with the average diameter of resected tumor being 1.2 cm (range 0.2–3.5 cm). Pseudoepitheliomatous hyperplasia was noted in 11 tumors and in one vulvar GCT there was overlying in situ squamous cell carcinoma. Tumors were incompletely excised in 24 of 56 patients having adequate followup; only five of these 24 patients experienced a local recurrence of tumor. Malignant behavior was not observed. Results of histochemical and ultrastructural study are briefly discussed. The precise histogenesis of GCT is uncertain but Schwann cell origin is favored in most cases.
Distant metatases of carcinoma of tonsillar region: A study of 475 patients
Authors: Chung Tae Soo , Stefani S. 
Published: February 2007

AbstractThe records of 471 patients with carcinoma of the tonsillar region seen at the Veterans Administration Medical Center, Hines, Illinois, have been reviewed to determine the incidence and location of distant metastases. All patients were male and with histologically proved diagnosis. Seventy‐two patients (15%) of 471 and 33(29%) of 115 patients who underwent autopsy were found to have distant metastases. Squamous cell carcinoma was by far the most common cell type (88 %); however lymphoepithelioma showed the highest incidence of distant metastases. Lung, liver, and bone were the most common anatomical sites of involvement, and thorough work‐up of these organs is highly recommended before initiating definitive treatment and during follow‐up care.
Malignant mesothelioma: A metastasis to the face
Authors: Edstrom Lee E. , Dawson Peter J. , Kohler John , Demeester Thomas R. 
Published: February 2007

AbstractMalignant mesothelioma can be a confusing disease, resembling either carcinoma or sarcoma. Although it usually causes death rapidly by local and regional spread, distant metastases may be seen more frequently as more effective therapy controls local disease and prolongs life.Our patient's local and then regional mesothelioma was controlled by aggressive treatment, which allowed him nearly two years of productive life before a metastasis to the right infraorbital region occurred. He died shortly there‐after with widespread metastases.This is the first reported case of mesothelioma metastatic to the face. This case also emphasizes the association of malignant mesothelioma with asbestos exposure, and points out advances in pathologic techniques that aid in the diagnosis of the disease.
Mycosis fungoides associated with florid sarcoid reactions
Authors: Schwartz Robert Allen , Burgess Gordon H. , Holtermann Ole A. , Baitman Linda , Milgrom Halina , Klein Edmund , Case Robert W. , Kenny Patrick G. W. , Birnkrant Arthur P. , Yaqub Mohammad 
Published: February 2007

AbstractWe report a 59‐year‐old woman with disease manifestations diagnosed as mycosis fungoides (MF), as well as findings of sarcoidosis. The concurrence of these two disorders, both of which may be associated with basic immunopathogenic factors, has been reported. Histologically, the cutaneous findings of both non‐caseating granulomas and an infiltrate compatible with MF in the same site leads to a discussion of granulomatous MF. Whether granulomatous MF simply represents sarcoidosis developing concomitantly with MF lymphoma or is, in fact, a distinct clinical and histologic type of MF is discussed. Reasons why granulomatous MF, like granulomators Hodgkin disease, might have a more favorable prognosis than the usual type of MF are considered.
Serum UDP‐galactosyl transferase as a potential biomarker for breast carcinoma
Authors: Paone Joseph F. , Phillip Waalkes T. , Robinson Baker R. , Shaper Joel H. 
Published: February 2007

AbstractUDP‐galactose:N‐acetylglucosamine galactosyltransferase (GT) is a membrane‐bound enzyme active in the biosynthesis of the carbohydrate moiety of glyco‐proteins and glycolipids. A soluble form of GT, present in human serum, has recently been found to be elevated in the presence of various neoplasms. In this study, GT levels were measured in randomized serum samples obtained from normal controls (group I, n = 49), patients with benign breast disease (group II, n = 46), disease controls (group III, n = 50), patients with primary breast carcinoma (group IV, n = 53), and untreated metastatic breast cancer (group V, n = 23). Although substantial serum GT elevations were observed in individual control patients with active inflammatory or metabolic diseases, the mean GT levels were signficantly higher in the groups with breast carcinoma (P < 0.001, 0.001, 0.02; P < 0.001, 0.001, 0.001 for groups IV and V vs groups, 1, II, and III, respectively). Furthermore, when serum GT levels were correlated with the preoperative clinical stage of breast cancer, significant elevations were found in 14.3% (3/21) of stage I, 66.7% (8/12) of stage II, 78.6% (11/14) of stage III, and 96.5% (28/29) of stage IV patients. These data indicate that serum GT levels are elevated in the presence of breast carcinoma and that the enzyme elevations correlate positively with the clinical stage of disease. Serum GT may be potentially useful in the detection of recurrent breast carcinoma and as a marker of tumor response to therapy for advanced disease.