bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel deep learning model for detection of inconsistency in e-commerce websites
Authors: Kassem Mohamed A. , Abohany Amr A. , El-Mageed Amr A. Abd , Hosny Khalid M. 
Published: March 2024

AbstractOn most e-commerce websites, there are two crucial factors that customers rely on to assess product quality and dependability: customer reviews provided online and related ratings. Reviews offer feedback to customers about the product’s merits, reasons for negative reviews, and feelings of satisfaction or dissatisfaction with the provided service. As for ratings, they express customer opinions about the product’s quality as numerical values from one to five (one or two for the worst opinion, three for the neutral opinion, and four or five for the best opinion). Usually, the customer reviews may be inconsistent with their relevant ratings; the customer may write the worst review despite providing a four- or five-star rating or write the best review with only a one- or two-star rating. Due to this inconsistency, customers may need help to identify relevant information. Therefore, it is required to develop a model that can classify reviews as either positive or negative, depending on the polarity of thoughts, to demonstrate if there is an inconsistency between customer reviews and their actual ratings by comparing them with the ratings resulting from the model. This paper proposes an efficient deep learning (DL) model for classifying customer reviews and assessing whether there is inconsistency. The recommended model’s performance and stability are examined on a large dataset of product reviews from Amazon e-commerce. The experimental findings showed that the proposed model dominates and significantly outperforms its peers regarding prediction accuracy and other performance measures.
Change in systemic steroid use and surgery rate in patients with inflammatory bowel disease: a Japanese real-world database analysis
Authors: Hirayama Daisuke , Hyodo Shinichiro , Morita Kazuo , Nakase Hiroshi 
Published: March 2024

Abstract
Background
Corticosteroids are recommended only for induction of remission in inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD). This study aimed to evaluate the change in pharmacologic treatment use, particularly systemic corticosteroids, over approximately 30 years, and the impact of biologics on IBD treatment since their appearance in the 2000s.

Methods
This retrospective study conducted in Japan used data from the Phoenix cohort database (January 1990 to March 2021). Patients with disease onset at age ≥ 10 years who received treatment for UC or CD between January 1990 and March 2021 were included. Outcome measures were change in IBD treatments used, total cumulative corticosteroid doses, initial corticosteroid dose, duration of corticosteroid treatment, and surgery rate.

Results
A total of 1066 and 579 patients with UC and CD, respectively, were included. In UC, the rate of corticosteroid use as initial treatment was relatively stable regardless of the year of disease onset; however, in CD, its rate decreased in patients who had disease onset after 2006 (before 2006: 14.3–27.8% vs. after 2006: 6.6–10.5%). Compared with patients with disease onset before biologics became available, cumulative corticosteroid doses in both UC and CD, and the surgery rate in CD only, were lower in those with disease onset after biologics became available.

Conclusions
Since biologics became available, corticosteroid use appears to have decreased, with more appropriate use. Furthermore, use of biologics may reduce surgery rates, particularly in patients with CD. UMIN Clinical Trials Registry; UMIN000035384.
Deformation Behavior and Seismic Characteristics of Sandy Facies Opalinus Clay During Triaxial Deformation Under Dry and Wet Conditions
Authors: Schuster Valerian , Rybacki Erik , Bonnelye Audrey , Dresen Georg 
Published: March 2024

AbstractUnconsolidated, undrained triaxial deformation tests were performed on sandy facies Opalinus Clay at 50 MPa confining pressure to characterize the effect of water and microfabric orientation on the deformation behavior, mechanical properties, and P-wave velocity evolution. Dry and wet (≈ 8 and > 95% initial water saturation, respectively) samples with 12.6 ± 0.4 vol% porosity were deformed parallel and perpendicular to the bedding direction at a constant strain rate of 5 × 10–6 s−1. Dry samples revealed semi-brittle behavior and exhibited strain localization at failure, while deformation was more ductile at saturated conditions, promoting stable, slow faulting. Peak strength, Young’s modulus, and number of cumulative acoustic emissions decreased significantly for wet samples compared to dry samples; the opposite was observed for Poisson’s ratio. P-wave velocity anisotropy was significantly altered by differential stress, primarily due to the interplay between pore and fracture closure and stress-induced microcrack formation. For samples that were deformed perpendicular to bedding, we observed a reduction and reversal of P-wave velocity anisotropy with increasing differential stress, whereas anisotropy of parallel samples increased. The results suggest that water saturation reduces the pressure at the brittle-ductile transition and that the elastic properties and anisotropy of sandy facies Opalinus Clay can be significantly altered in an anisotropic stress field, e.g., adjacent to fault zones or tunnel excavations. Changes in elastic anisotropy are primarily controlled by the orientation between the pre-existing microfabric and the maximum principal stress direction, stress magnitude, and the degree of water saturation.
Synergistic effect of mesoporous silica nanocarrier-assisted photodynamic therapy and anticancer agent activity on lung cancer cells
Authors: Güleryüz Burcu , Işık Ayşe , Gülsoy Murat 
Published: March 2024

Abstract
Investigating combined treatment methodologies is crucial for addressing the complex nature of cancer. As an emerging strategy, nano-biotechnology encourages the design of unique nanocarriers possessing simultaneous therapeutic application properties. This study aims to explore the combined effects of photodynamic and anticancer treatments using a multifunctional nanocarrier system co-administering the photosensitizer IR780 and the anticancer agent curcumin (Cur) on lung cancer cells. Nanocarriers were prepared by encapsulation IR780 and Cur inside polyethylene glycol-capped mesoporous silica nanoparticles (Cur&IR780@MSN). Various concentrations of nanocarriers were evaluated on A549 cells following 5 min NIR laser light (continuous wave, 785 nm, 500 mW/cm2) irradiation. The internalization of nanocarriers was observed through the fluorescence of Cur. Changes in cell viability were determined using the MTT assay and AO/PI staining. A scratch assay analysis was also performed to examine the impact of combined treatments on cell migration. Characterization of the nanocarriers revealed adequate hydrophobic drug loading, temperature-inhibited feature, enhanced reactive oxygen species generation, a pH-dependent curcumin release profile, and high biocompatibility. Cur&IR780@MSN, which enabled the observation of synergistic treatment efficacy, successfully reduced cell viability by up to 78%. In contrast, monotherapies with curcumin-loaded nanocarriers (Cur@MSN) and IR780-loaded nanocarriers (IR780@MSN) resulted in a 38% and 56% decrease in cell viability, respectively. The constructed Cur&IR780@MSN nanocarrier has demonstrated remarkable performance in the application of combination therapies for lung cancer cells. These nanocarriers have the potential to inspire future studies in tumor treatment methods.
Advances in epigenetic alterations of chronic lymphocytic leukemia: from pathogenesis to treatment
Authors: Zhang Xin , Wang Hua , Zhang Ya , Wang Xin 
Published: March 2024

AbstractChronic lymphocytic leukemia (CLL) is a heterogeneous disease with alterations in genetic expression and epigenetic modifications. In recent years, the new insight into epigenetics in the pathogenesis of CLL has been developed considerably, including DNA methylation, histone modification, RNA methylation, non-coding RNAs as well as chromatin remodeling. Epigenetic modification regulates various processes such as stem cell biology, cell growth, and tumorigenesis without altering gene sequence. Growing evidence indicates that the disturbance of gene expression profiles which were regulated by epigenetic modifications exerts vital roles in the development and progress in CLL, which provides novel perspectives to explore the etiology of CLL. In addition, the integration with epigenetic therapeutic targets and the in-depth understanding of epigenetic therapy contribute to develop new therapeutic strategies for CLL. Herein, the present review discusses the advances of epigenetic alterations in the pathogenesis, diagnosis, and prognostic assessment of CLL patients and also highlights existing and emerging agents targeting epigenetic regulators.
Use of tryptic peptide MALDI mass spectrometry imaging to identify the spatial proteomic landscape of colorectal cancer liver metastases.
Authors: Li Celine Man Ying , Briggs Matthew T. , Lee Yea-Rin , Tin Teresa , Young Clifford , Pierides John , Kaur Gurjeet , Drew Paul , Maddern Guy J. , Hoffmann Peter , Klingler-Hoffmann Manuela , Fenix Kevin 
Published: March 2024

AbstractColorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. CRC liver metastases (CRLM) are often resistant to conventional treatments, with high rates of recurrence. Therefore, it is crucial to identify biomarkers for CRLM patients that predict cancer progression. This study utilised matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) in combination with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to spatially map the CRLM tumour proteome. CRLM tissue microarrays (TMAs) of 84 patients were analysed using tryptic peptide MALDI-MSI to spatially monitor peptide abundances across CRLM tissues. Abundance of peptides was compared between tumour vs stroma, male vs female and across three groups of patients based on overall survival (0-3 years, 4-6 years, and 7+ years). Peptides were then characterised and matched using LC-MS/MS. A total of 471 potential peptides were identified by MALDI-MSI. Our results show that two unidentified m/z values (1589.876 and 1092.727) had significantly higher intensities in tumours compared to stroma. Ten m/z values were identified to have correlation with biological sex. Survival analysis identified three peptides (Histone H4, Haemoglobin subunit alpha, and Inosine-5’-monophosphate dehydrogenase 2) and two unidentified m/z values (1305.840 and 1661.060) that were significantly higher in patients with shorter survival (0-3 years relative to 4-6 years and 7+ years). This is the first study using MALDI-MSI, combined with LC-MS/MS, on a large cohort of CRLM patients to identify the spatial proteome in this malignancy. Further, we identify several protein candidates that may be suitable for drug targeting or for future prognostic biomarker development.
Circulating Bone morphogenetic protein 9 (BMP9) as a new biomarker for noninvasive stratification of nonalcoholic fatty liver disease and metabolic syndrome
Authors: Yang Yuchen , Gu Meihong , Wang Wei , Li Shan , Lu Jinlai , Sun Qinjuan , Hu Miao , Zhong Lan 
Published: March 2024

AbstractNonalcoholic fatty liver disease (NAFLD) is closely related to metabolic syndrome (MetS). Bone morphogenetic protein 9 (BMP9) is an essential factor in glucose, lipid and energy metabolism. This study aims to investigate whether BMP9 can serve as a serological marker for the severity of NAFLD or MetS. Blood samples, clinical data and FibroTouch test were collected from consecutively recruited 263 individuals in Shanghai East hospital. All the participants were divided into three groups: the healthy controls, nonalcoholic fatty liver (NAFL) group and nonalcoholic steatohepatitis (NASH) at-risk group according to the results of FibroTouch test and liver function. Serum BMP9 levels were measured by enzyme-linked immunosorbent assay. Serum BMP9 levels were positively correlated with transaminase, triglyceride, fasting plasma glucose, glycated hemoglobin (HbA1c) and uric acid while it showed a downward trend as the increasing number of MetS components. Furthermore, it differentiated NASH at-risk (58.13 ± 2.82 ng/L) from the other groups: healthy control (70.32 ± 3.70 ng/L) and NAFL (64.34 ± 4.76 ng/L) (p < 0.0001). Controlled attenuation parameter of liver fat and liver stiffness measurement were negatively correlated with BMP9 levels, while high-density lipoprotein levels were positively correlated. The risk of developing NAFLD increased along with elevated serum BMP9 and BMI, and a significantly higher risk was observed in men compared to women. BMP9 should be considered a protective factor for the onset and development of NAFLD, as well as a promising biomarker for the severity of the NAFLD and MetS.
A model-based reference architecture for complex assistive systems and its application
Authors: Michael Judith , Shekhovtsov Volodymyr A. 
Published: March 2024

AbstractComplex assistive systems providing human behavior support independent of the age or abilities of users are broadly used in a variety of domains including automotive, production, aviation, or medicine. Current research lacks a common understanding of which architectural components are needed to create assistive systems that use models at runtime. Existing descriptions of architectural components are focused on particular domains, consider only some parts of an assistive system, or do not consider models at runtime. We have analyzed common functional requirements for such systems to be able to propose a set of reusable components, which have to be considered when creating assistive systems that use models. Such components constitute a reference architecture that we propose within this paper. To validate the proposed architecture, we have expressed the architectures of two assistive systems from different domains, namely assistance for elderly people and assistance for operators in smart manufacturing in terms of compliance with such architecture. The proposed reference architecture will facilitate the creation of future assistive systems.
The pine bark beetle Ips acuminatus: an ecological perspective on life-history traits promoting outbreaks
Authors: Papek Eva , Ritzer Elisabeth , Biedermann Peter H. W. , Cognato Anthony I. , Baier Peter , Hoch Gernot , Kirisits Thomas , Schebeck Martin 
Published: March 2024

AbstractThe bark beetle Ips acuminatus is an important pest in pine-dominated forests of Eurasia. Recently, the frequency of I. acuminatus outbreaks and mortality of host trees have increased, most likely as a result of climate change-related alterations in environmental conditions. Therefore, detailed information on the species’ natural history is essential to understand its potential to damage forests and to apply sustainable management measures. We provide a comprehensive overview on the life history of I. acuminatus, focusing on traits that might explain outbreaks and the ability to cause tree mortality. We review its importance for European forestry, outbreak behavior, host plant usage, reproductive biology, temperature-dependent development, diapause and overwintering behavior, and interactions with fungi, bacteria, nematodes and other arthropods. Interestingly, I. acuminatus has a strong nutritional dependency on the fungus Ophiostoma macrosporum, underlined by the presence of a prominent oral mycetangium, a spore-carrying organ, in females, which is not known for other Ips species. Moreover, I. acuminatus can reproduce sexually and asexually (pseudogamy). Additionally, information on the species’ evolutionary past provides valuable insights into the origin of certain traits. We present a phylogeny of the genus Ips and examine selected life-history traits in an evolutionary context. Together with its sister species Ips chinensis, I. acuminatus forms a separate clade within Ips. The ancestor of Ips bark beetles originated about 20 million years ago and was a pine-colonizing species inhabiting the Holarctic. Finally, open fields of research are identified to guide future work on this ecologically and economically important pine bark beetle.
Do Miniature Eye Movements Affect Neurofeedback Training Performance? A Combined EEG-Eye Tracking Study
Authors: Kober Silvia Erika , Wood Guilherme , Schuster Sarah , Körner Christof 
Published: March 2024

AbstractEEG-based neurofeedback is a prominent method to modulate one’s own brain activity in a desired direction. However, the EEG signal can be disturbed by artifacts, e.g., eye movements, which can consequently confound the neurofeedback performance. Involuntary miniature eye movements can be hardly detected by conventional EEG correction methods such as recording the electro-oculogram (EOG) and subtracting EOG activity from the EEG signal. However, such miniature eye movements can influence EEG activity, especially in the Gamma frequency range, enormously. In the present study, we investigated whether power in different EEG frequencies can be effectively modulated by self-control of brain signals during neurofeedback training and/or whether changes in EEG power are provoked by miniature eye movements during the training. To this end, 24 participants performed one session of SMR and one session of Gamma neurofeedback training. Additionally, in each training session sham feedback was performed. An eye tracker was used to detect miniature eye movements (< 1°) during neurofeedback training. About two thirds of the participants were able to increase their SMR power over the course of NF training, while one third was able to increase Gamma power. Generally, miniature eye movements induced a strong Gamma power increase. The number of eye movements also increased numerically over the course of the NF training. However, we did not find a significant relationship with the NF training performance. This is a first indication that miniature saccades do not affect NF training performance, but should not be neglected during NF training. Our results have to be confirmed in future studies.
Unraveling microbial processes involved in carbon and nitrogen cycling and greenhouse gas emissions in rewetted peatlands by molecular biology
Authors: Gios Emilie , Verbruggen Erik , Audet Joachim , Burns Rachel , Butterbach-Bahl Klaus , Espenberg Mikk , Fritz Christian , Glatzel Stephan , Jurasinski Gerald , Larmola Tuula , Mander Ülo , Nielsen Claudia , Rodriguez Andres F. , Scheer Clemens , Zak Dominik , Silvennoinen Hanna M. 
Published: March 2024

AbstractRestoration of drained peatlands through rewetting has recently emerged as a prevailing strategy to mitigate excessive greenhouse gas emissions and re-establish the vital carbon sequestration capacity of peatlands. Rewetting can help to restore vegetation communities and biodiversity, while still allowing for extensive agricultural management such as paludiculture. Belowground processes governing carbon fluxes and greenhouse gas dynamics are mediated by a complex network of microbial communities and processes. Our understanding of this complexity and its multi-factorial controls in rewetted peatlands is limited. Here, we summarize the research regarding the role of soil microbial communities and functions in driving carbon and nutrient cycling in rewetted peatlands including the use of molecular biology techniques in understanding biogeochemical processes linked to greenhouse gas fluxes. We emphasize that rapidly advancing molecular biology approaches, such as high-throughput sequencing, are powerful tools helping to elucidate the dynamics of key biogeochemical processes when combined with isotope tracing and greenhouse gas measuring techniques. Insights gained from the gathered studies can help inform efficient monitoring practices for rewetted peatlands and the development of climate-smart restoration and management strategies.
Biological functions and dysfunctions: a selected dispositions approach
Authors: Hundertmark Fabian , van den Bos Marlene 
Published: March 2024

AbstractJustin Garson has recently argued that proper functions are proximal activities of traits selected by phylogenetic or ontogenetic selection processes, and that traits are dysfunctional only if they cannot perform their proper functions for constitutional reasons. We partially agree with Garson, but reject the view that functions are proximal activities, as well as his account of dysfunctions. Instead, we propose our own theory that biological functions are selected dispositions and that a trait is dysfunctional in virtue of not having the dispositions for which it was selected. This account can explain both defects (or dysfunctions in Garson’s sense) and dysfunctions due to environmental factors. Moreover, it offers a neat way to explain the graduality of dysfunction.
Retrospective genetic testing (Traceback) in women with early-onset breast cancer after revised national guidelines: a clinical implementation study
Authors: Augustinsson Annelie , Loman Niklas , Ehrencrona Hans 
Published: March 2024

Abstract
Purpose
This study focused on identifying a hereditary predisposition in women previously diagnosed with early-onset breast cancer through a retrospective outreach activity (Traceback). The objectives were to evaluate the possible clinical implementation of a simplified Traceback strategy and to identify carriers of pathogenic variants among previously untested women.

Methods
Three hundred and fifteen Traceback-eligible women diagnosed with breast cancer at 36–40 years in Southern Sweden between 2000 and 2019 were identified and offered an analysis of the genes ATM, BARD1, BRCA1, BRCA2, CHEK2, PALB2, RAD51C, and RAD51D through a standardized letter. Women who chose to participate were asked about their experiences through a questionnaire. The workload for the study personnel was measured and recorded.

Results
One hundred and seventy-six women underwent genetic testing and pathogenic variants were identified in 9.7%: ATM (n = 6), BARD1 (n = 1), BRCA1 (n = 3), CHEK2 (n = 5), and PALB2 (n = 2). Women with normal test results were informed through a standardized letter. Carriers of pathogenic variants were contacted by telephone and offered in-person genetic counseling. One hundred and thirty-four women returned the subsequent questionnaire. Most study participants were satisfied with both written pre- and post-test information and many expressed their gratitude. The extra workload as compared to routine clinical genetic counseling was modest (8 min per patient).

Conclusion
The insights from the participants’ perspectives and sentiments throughout the process support the notion that the Traceback procedure is a safe and an appreciated complement to routine genetic counseling. The genetic yield of almost 10% also suggests that the associated extra workload for genetic counselors could be viewed as acceptable in clinical implementation scenarios.