bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravascular crystals provide diagnostic clue in diagnosis of monoclonal cryoglobulinemia
Authors: Kindel Susan E. , Lu Peter , Smoller Bruce R. 
Published: July 2006

AbstractMonoclonal cryoglobulinemia is a relatively uncommon disorder that may involve the skin at the time of presentation. We present here a case in which the histological observation of eosinophilic crystals within dermal blood vessels provided the initial diagnostic clue to making the final diagnosis.
Localized hyperpigmentation and pruritus on the upper back
Authors: Peña‐Penabad C. , Gonzalez‐Asensio M.P. , García‐Silva J. , Armijo M. 
Published: July 2006

AbstractThis retrospective study of 28 patients with pruritus and hyperpigmentation located on the upper half of the back, without involvement of other skin areas, includes 8 cases of macular amyloidosis, four neurodermatitis and 16 compatible with what has been described as notalgia paresthetica (NP). With the exception of the amyloid deposition, we did not find histopathological data that differentiated between macular amyloidosis and NP, since in both processes we found necrotic keratinocytes and melanophages. The differential diagnosis and the current nosological situation of the hyperpigmentation localized on the upper back are reviewed. A diagnostic protocol is proposed.
Cyclosporin‐A in the treatment of atopic dermatitis: effects on the immune system and clinical efficiency
Authors: Masci Silvio , Feliciani Claudio , Gravante Massimo , Proietto Gianluca , Andreassi Maria , Amatetti Massimo , Amerio Pierluigi 
Published: July 2006

AbstractIn order to evaluate the effect of Cyclosporin–A (CyA) at doses of 5 mg/kg per day in atopic dermatitis we studied clinical effects, immunoglobulin production, lymphocytes subset, immunphenotype and local cytokine production in seven patients before and after 3 months CyA therapy. Clinically CyA was very effective in eliminating pruritus, erythema and vescicles with no significant adverse side effects. Using flow cytometric analysis we demonstrated that CyA treatment restored an overexpression of circulating CD25‐positive cells. Similar results have been recorded with HLA‐DR expression. CyA normalized the number of CD29 cells which were reduced in the blood of patients before starting treatment. Furthermore, after treatment, several cytokines (IL‐2, IL‐1α and IL‐1β) had diasappeared from the epidermis.
Treatment of mycosis fungoides with etretinate and low‐dose interferon α2a
Authors: Sánchez‐Pérez Javier , Fernández‐Herrera Jesús , Ríos Luis , Peñas Pablo F. , Dorado‐Bris José M. , García‐Díez Amaro 
Published: July 2006

AbstractAimsTo evaluate the efficiency and tolerance of a treatment regime with etretinate and low‐dose interferon‐α2a(IFN α2a) in mycosis fungoides.BackgroundAlthough there is no curative therapy for mycosis fungoides, remissions have been induced with etretinate and IFNα2a, even in advanced stages, Recently, it has been shown that this combination is more effective in the induction and maintenance of the response than the separate administration of each drug.MethodsProspective study which includes nine patients with mycosis fungoides treated with 0.7 mg/kg/day of etretinate and 3 × 106IU/day of subcutaneous IFNα2aduring the first 3 months. Afterwards, the dosage of INFα2awas modified in accordance with the response, without the daily dosis of INFα2asurpassing 6 × 106[U. Results:At the end of the study, a favourable response was obtained in four of six patients (66%), of whom one showed a complete and three partial remission. Two patients were non‐evaluable and one discontinued therapy with partial remission of disease due to adverse effects attributable to etretinate. Side‐effects were dose‐dependent and reversible.ConclusionsThe combination of etretinate, 0.7 mg/kg/day, and IFNα2a, 3 × 106subcutaneous IU/day, could be recommended to induce substained complete remission in later stages of cutaneous T‐cell lymphoma.
Palmar filiform or spiny hyperkeratosis associated with pulmonary tuberculosis
Authors: Gimenez‐Arnau Ana , Camarasa José G. 
Published: July 2006

AbstractA case of palmar filiform or spiny hyperkeratosis in a 50‐year‐old man is reported. The development of pulmonary tuberculosis was followed by “music box spine” keratotic plugs and pits on both hands, apart from the palmar creases. Histological examination revealed a well delineated column of hyperkeratosis with basal parakeratosis not developing a true cornoid lamella.This case is interesting because of its rarity, the lack of heredity and the clinical association with pulmonary tuberculosis, although Herman (1973) reported bronchial carcinoma with punctate porokeratosis. We discuss the relationship between immunosuppression and the development of these cutaneous lesions. We also review cases described as “porokeratosis punctata palmaris et plantaris” clinically identical to our patient, who did not present true cornoid lamella. Palmar filiform hyperkeratosis is an unespecific keratinization disorder which could be considered secondary to other diseases.
Exudative discoid and lichenoid chronic dermatosis (Sulzberger‐Garbe): presentation with a puzzling penile plaque*
Authors: Trüeb Ralph M. 
Published: July 2006

AbstractObjective Report of two cases of exudative discoid and lichenoid dermatosis (Sulzberger‐Garbe), with typical penile lesions. Differential diagnosis of persistent penile plaques.Background Following remission of the generalized eruption of exudative discoid and lichenoid dermatosis (Sulzberger‐Garbe), it is not unusual to see a single remaining lesion localized on the penis. Since Sulzberger et al. (Sulzberger MB, Witten VH, Hunt JA. Puzzling persistent penile plaques. Arch Dermatol 1956:73:101‐109) reviewed dermatoses presenting with puzzling persistent penile plaques in 1955, further dermatoses have evolved as important differential diagnoses. Much controversy has arisen as to the justification of exudative discoid and lichenoid dermatosis (Sulzberger‐Garbe) as a disease entity.Conclusions Diagnosis of most cases of persistent plaques of dermatitis on the penis is possible with a careful examination of the entire skin, and a thorough history to discover past lesions. The possibility of malignancy makes a biopsy mandatory. Exudative discoid and lichenoid chronic dermatosis (Sulzberger‐Garbe) typically responds well to systemic steroids. Intrale‐sional triamcinolone acetonide has been demonstrated to be effective in the treatment of a persistent penile plaque in exudative discoid and lichenoid dermatosis (Sulzberger‐Garbe), and may be helpful in discontinuing or reducing systemic therapy to a level compatible with long‐term treatment.
Glycolic acid and its use in dermatology
Authors: Cotellessa C. , Peris K. , Chimenti S. 
Published: July 2006

AbstractGlycolic acid has distinctive pharmacologic properties that recommend it for topical use in a range of skin disorders: acne, aging and photoaging, keratoses, age spots. Future studies and more extensive and varied clinical trials would surely point out its therapeutic potential and extend its range of clinical applications.
Nifedipine‐induced facial telangiectasia
Authors: Vejlstrup Eva , Poskitt Louise , Wojnarowska Fenella 
Published: July 2006

AbstractNifedipine is a calcium‐channel blocker widely prescribed for vasodilation of coronary and peripheral vessels. We describe an elderly woman who, whilst taking nifedipine. developed facial telangiectasia. On discontinuing the drug the telangiectasia resolved markedly.
Coculture of mast cells with psoriatic fibroblasts: an experimental system for studying the two cell interactions
Authors: Levi‐Schaffer Francesca , Klapholz Laurent , Weinrauch Louis , Shalit Meir 
Published: July 2006

AbstractIn this study we established a coculture system for rat peritoneal mast cells (MC) with psoriatic (PSO) dermal fibroblasts. Rat MC adhered within five minutes to the fibroblasts monolayer and their attachment and viability was maintained for at least 2‐3 days. Cocultured MC could be activated to release high percentages of histamine with compound 48/80 indicating that they retained their full functional activity. Attachment, viability and functional activity were similar for MC seeded on PSO fibroblasts or on normal human fibroblasts (NOR) used as a control. This would indicate that PSO fibroblasts altered biochemical characteristics do not interfere with these MC properties. We suggest that this coculture system is a suitable in vitro defined model to study mutual effects of MC and fibroblasts in psoriasis.
Molecular response of human keratinocytes to ultraviolet radiation: an attempt to understand the pathogenesis of acute and chronic photodamage
Authors: Garmyn Marjan 
Published: July 2006

AbstractThe acute molecular response of human keratinocytes to solar simulated radiation or UVB includes modulation in gene expression of various cytokines and growth regulatory proteins. This genetic response is consistent with the immunemodulating effect of UV and an effect of UV on cell kinetics, including growth arrest and subsequent hyperproliferation. The ultimate signal and signal transduction pathway resulting in the induction or suppression of gene transcription after UV will further elucidate the underlying molecular mechanisms of acute photodamage of human skin. Photoaging appears to decrease the expression of differentiation associated genes. Photocarcinogenesis, the ultimate consequence of chronic photodamage, is associated with permanent changes in growth regulatory genes and differentiation associated genes. This may be caused by gene (in)activation through mutations, amplifications or deletions, us demonstrated for the tumor‐suppressor gen p53 and the ras proto‐oncogenes.
Vitiligo is associated with a significant increase in HLA‐DR6 and a decrease in DQw2 antigens in Northern Italian patients.
Authors: Valsecchi R. , Bontempelli M. , Cainelli T. , Leghissa P. , Di Landro A. 
Published: July 2006

AbstractBackground Pathogenesis of vitiligo is still unclear; although the mechanism of melanocyte destruction is not know, reports of abnormalities in immunoregulation and immune reactivity in these patients support the autoimmune theory of the disease. A wide variety of autoimmune disorders have been associated with HLA antigens, and at the present time there are conflicting results about the association between vitiligo and HLA phenotypes.Objective and methods To determine if some increases in certain HLA antigens in the Northern Italian population suffering from vitiligo exist, we studied 33 patients, and we compared the results obtained with those observed in 443 control subjects of the same geographical area.Results HLA‐DR and DQ typing showed a statistically significant increase of DR6 antigen and a statistically significant decrease of DQw2 type. The comparison of the phenotype frequencies of the loci A,B and C observed in the patients and in the control group showed no statistically significant differences after the p correction.Conclusion This study showed that genes in or closely linked to the HLA‐DR and DO regions of the major histocompatibility complex could influence susceptibility to vitiligo in Northern Italian patients.
Clearing of psoriatic erythroderma following heliotherapy in the Dead Sea area
Authors: Giryes Hani , Sukenik Shaul , Halevy Sima 
Published: July 2006

AbstractWe report herein a patient suffering from psoriatic erythroderma and psoriatic arthritis treated successfully in the Dead Sea area. Sun exposure (heliotherapy) and emollients, without any additional topical or systemic treatments, resulted in clearing of the erythroderma within 4 weeks of treatment. Additional regimens of climatotherapy and balneotherapy, given for another 2 weeks, led to marked alleviation of his arthritic complaints. The remission of skin disease persisted for 5 months without further therapy.
Leg ulcerations due to livedo vasculitis: successful combined therapy with pentoxifylline and nifedipine
Authors: Nikolova Kremena , Popov Janko , Obreshkova Elena 
Published: July 2006

AbstractWe report a patient with livedo vasculities with painful leg alterations in whom prolonged combined therapy with pentoxifylline and nifedipine of 2 years duration induced a remarkable and long‐lasting improvement of the disease. During the period no occurrence of the ulcerations has been observed.
Can we use radiotherapy alone in the treatment of keloids?
Authors: Supe Sanjay S. , Sharma Anil K. , Deka A.C. , Deka B.C. 
Published: July 2006

AbstractObjective The use of radiation for the treatment of keloids has been the topic of debate for years.Methods In this study, 46 symptomatic cases were treated with 90Sr‐90Y β‐rays. Patients were given four fractions of 5 Gy per fraction either as weekly or twice weekly schedules.Results Radiation dose of 20 Gy given twice weekly in four fractions showed response in 92% of the cases as compared to 81% in those receiving four fractions of 5 Gy weekly.Conclusion Further studies with numerous dose fractionation schedules would open up new dimensions in the radiotherapy of keloids.
Netherton's syndrome in two sisters. A ten year experience of therapy with retinoids
Authors: Groves S. , Dezfoulian B. , Bonardeaux Ch. , de la Brassinne M. 
Published: July 2006

AbstractNetherton's syndrome is a recessive autosomal disease associating ichthyosiform dermatosis, hair dysplasia and systemic involvement. (Netherton, 1958, Arch. Dermatol., Vol. 78, 483–487). We report the observation of two sisters who present the complete form of Netherton's syndrome. Both patients were treated with retinoids for more than ten years.
Leprechaunism
Authors: Barba Annalisa , Chieregato Carlo , Schena Donatella , Pizzo Paolo 
Published: July 2006

AbstractA 10‐year old girl with leprechaunism was studied by clinical examination, blood tests and skin biopsies. She is one of the few cases of such long survival and the first one with two missence mutations demonstrated in the alpha‐1 subunit of the insulin receptor. The case is interesting not only because of its rarity and typical morphology but also because nowadays it is possible to explain the clinical features at a metabolic and hormonal level.
Diagnosis and treatment of oral hairy leukoplakia
Authors: Mabruk Mohamed J.E.M.F. , Flint Stephen R. , Coleman David C. , Toner Mary , Atkins Gregory J. 
Published: July 2006

AbstractBackground Oral hairy leukoplakia (OHL) is a greyish white keratotic lesion occurring unilaterally or bilaterally on the lateral border or ventral surface of the tongue and occasionally at other mucosal sites. This lesion is seen in immunosuppressed individuals, usually in association with HIV infection.Aims The clinical and histopathological features of OHL are only sufficient to reach a presumptive diagnosis. Definitive diagnosis of OHL requires demonstration of the presence of Epstein‐Barr virus (EBV) within the OHL lesion. Prompt and accurate recognition of the condition is important, as it is an early and reliable sign of infection with human immunodeficiency virus (HIV).Conclusions A definitive diagnosis of OHL may be acheived by detection of EBV in the lesion through the use of immunohistochemistry or in situ hybridisation on biopsy material.
Measures of the effect of adult severe atopic eczema on quality of life
Authors: Finlay Andrew Y. 
Published: July 2006

Abstract Background Measures of the impact of severe eczema on patients’ lives are required for clinical, audit and political reasons, in order to argue for more resources for dermatology services. Objective The purpose of this study was to identify and measure the effects of severe eczema on quality of life of adults. Setting Dermatology hospital hased clinics throughout the United Kingdom. Methods Ninety‐two adults with severe atopic eczema completed a questionnaire concerning the effect of their disease on their quality of life. Results The mean Dermatology Life Quality Index was 18 (60%). S.D. 7.1. with subsections relating to “symptoms and feelings” and “treatment effects” scoring highest. Disease comparison utility questions demonstrated that patients with severe eczema consider that having diabetes (ratio=1.21) or hypertension (1.38) would be better than having eczema, whereas having bronchitis (0.89) would be worse than having eczema (if diseases equal, ratio = 1). Over the long term, atopic eczema affects family life in 80% of patients and sexual relationships in 57%. 32% of patients had lost a median income of £5000 over the previous year because of their eczema, and those patients who were working had lost a median of 5 days from work over the previous year. 50% of patients would be prepared to give up 2 h or more a day in order to have normal skin, and 74% (49%) of patients would be prepared to pay £1000 (£10,000) or more for a cure. Conclusion This study confirms the major impact of severe atopic eczema on the quality of life of adults.
Assesment of self application of four topical agents on genital warts in women
Authors: Frega A. , Stentella P. , Di Renzi F. , Chiaie L. Delle , Cipriano L. , Pachi A. 
Published: July 2006

AbstractAim To evaluate the effectiveness of topical medical therapy in women affected by HPV vulvoperineal warts, comparing four agents: Podophillotoxin 0.5% of solution. 5% topical 5‐FU cream. α‐IFN cream anc β‐IFN cream.Methods One hundred thirty‐four women with untreated vulvoperineal warts were enrolled. After colposcopic, cytological and histological assessment of HPV changes, the women affected were divided into four groups and treated by self‐application of one of the following agents: Podophillotoxin 0.5% solution, 5% topical 5‐FU cream. α‐IFN cream, and β‐IFN cream.Results A 71.8% CR (complete recovery) was reported by patients in the Podophilloloxin therapy group; a 50% CR in the 5%‐ topical 5‐FU cream group; a 27% CR in the α‐IFN group: and lastly a 34.2% CR in the β‐IFN cream group (P < 0.001).Conclusions The role of topical medical therapy of vulvoperineal warts remains limited in effectiveness, but the use of 5r/r topical 5‐FU and Podophyllotoxin, showed better efficacy compared to IFN. The results obtained were unchanged after one year follow‐up, showing that Podophylloloxin and 5% topical 5‐FU can be considered a valid therapeutic strategy.
Keratoacanthomas: human papillomavirus and herpes simplex virus associated?
Authors: Strumìa R. , Roveggio C. , Rotola A. , Monini P. , Cassai E. 
Published: July 2006

AbstractBackground A viral cause for keratoacanthoma has been postulated by many investigators. Recently, some investigators reported the identification of genital high risk human papilloma virus types 16 and 18 in keratoacanthomas from transplant recipients.Observations We analysed by polymerase chain reaction biopsies of six multiple keratoacanthomas and four solitary keratoacanthoma biopsies for the presence of the most common genital papilloma viruses. All keratoacanthomas included in the study had developed in skin areas exposed to sunlight. In addition. We analysed 16 normal skin tissue biopsies. Six of these control tissue biopsies were from sun‐exposed skin areas, while 10 were from skin areas not exposed to sunlight. None of the patients enrolled in the study had clinical evidence of immunosuppression. As herpes simplex virus is associated to a variety of skin diseases and might co‐operate with human papilloma virus in cervical cancer, the presence of this virus in bioptic specimens was also addressed.Results DNA sequences from oncogenic papilloma viruses type 16 and 18 were disclosed in two of four solitary keratoacanthomas, three of six multiple keratoacanthomas and four of six biopsies from sun‐exposed normal skin. Non‐oncogenic papilloma viruses (type 6 or 11) were detected only in one biopsy from a multiple keratoacanthoma, and herpes simplex virus DNA was disclosed in one solitary keratoacanthoma, one multiple keratoacanthoma and one tissue biopsy from sun‐exposed skin. All specimens positive for herpes simplex virus were co‐infected with human papilloma virus type 16, but this association was not statistically significant (Fisher's exact test; P= 0.14). None of the tissue biopsies from sun‐protected normal skin was positive for these viruses. The difference of viral prevalence in sun‐exposed and non‐ exposed skin was statistically significant (P= 1.5 × 10−3).Conclusions In this study, human papilloma virus type 16 was detected with a high prevalence in keratoacanthomas and normal skin from immunocompetent individuals. The different prevalence of viral DNA in sun‐exposed and non‐exposed skin suggests that sunlight may favour viral infection. The comparable prevalence of viral DNA in neoplastic and normal tissue from skin areas exposed to sunlight would indicate that human papilloma virus infection occurred after the onset of neoplastic proliferation. In turn, the rapid growth of keratoacanthomas and the high viral prevalence (50%) would imply a high overall rate of infection (and/or re‐infection). The role of herpes simplex virus in this cutaneous pathology in unclear.
Cutaneous lesions of disseminated cryptococcosis as the initial presentation of advanced HIV infection
Authors: Calista Donato , Stagno Alessandro , Landi Christian 
Published: July 2006

AbstractCutaneous lesions of disseminated cryptococcosis as the first clinical evidence of acquired immunodeficiency Syndrome (AIDS) is described in three cases. The clinical diagnosis was difficult because of the polymorphism of lesions, absence of general symptoms and the patients’unawareness of their HIV infection. Patient I had central nervous system involvement and a poor prognosis. Patients 2 and 3 had cutaneous lesions only and have remained in relatively good health at 18‐ and 14‐month follow‐ups, respectively, after treatment. The patients were treated with amphotericin B 0.5mg/kg per day for 6 weeks and oral fluconazole at 300 mg/day. The cutaneous lesions healed in 30 days. Because the high risk of relapse, long‐term suppressive therapy was instituted with oral fluconazole 300 mg/day. supplemented with three weekly amphotericin infusions. To the best of our knowledge, cutaneous cryptococcosis as the presenting sign of HIV infection has not been previously reported in medical literature.
Non‐tuberculous mycobacterial skin infections
Authors: Hautmann Giuseppe , Katsambas Andreas , Lotti Torello 
Published: July 2006

AbstractGeneral description The mycobacteria are a large genus which includes important pathogens of man and other vertebrates, apparently harmless commensals, and free‐living saprophytes. The relative importance of non‐tuberculous mycobacterial diseases has been undergoing evolution during the past few years and further changes and modifications are expected to occur in the near future. In this paper we review the microbiological, clinical, histological and therapeutical aspects of the most important human pathogens of non–tuberculous mycobacteria.Learning objective At the conclusion of this learning activity, participants should be able to describe the pathogenesis. the microbiological, clinical and histological features of non‐tuberculous mycobacterial skin infections and should be able to diagnose and treat these skin diseases.
Serum level of major basic protein indicates disease activity in atopic dermatitis
Authors: Ikai Kouichi , Nakajima Naoko , Ozaki Motoaki , Furukawa Ikuko , Aoshima Toshiyuki , Mitani Tsuneo , Sawami Mari , Sayama Shigetoshi , Omoto Mitsuyoshi , Uehara Masami , Imamura Sadao 
Published: July 2006

AbstractWe evaluated the serum levels of major basic protein (MBP), assayed using an MBP radioimmunoassay kit. and the effect of an anti‐allergic agent, ketotifen, which has strong anti‐eosinophil activity, in 56 atopic dermatitis (AD) patients. The serum MBP level was significantly lower (660.11 ± 34.52 ng/ml, P < 0.05) after administration of ketotifen (1 mg twice a day) for 8 weeks than before treatment (774.98 ± 48.64 ng/ml). These findings suggest that serum MBP levels are a useful indicator of AD activity and that anti‐allergic agents can have an effect on eosinophil involvement in AD.