bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Experimental Investigation of Supportive
Tactile Communication During Esteem Support Conversations
Authors: Shebib Samantha J. , Boumis Josephine K. , Allard Amanda , Holmstrom Amanda J. , Mason Adam J. 
Published: April 2024

AbstractThe present study examines how supportive touch impacts evaluations of
esteem support content containing high emotion-focused (HEF) or high problem-focused
(HPF) messages during observed esteem support interactions. A 2 (verbal content;
i.e., HEF or HPF) by 2 (nonverbal content; i.e., presence or absence of supportive
tactile communication) experiment was conducted to test for main and interactional
effects. Results revealed that HEF conditions were perceived to be more effective by
observers at enhancing the recipient’s state self-esteem, state self-efficacy, and
alleviating distress compared to HPF conditions. The supportive tactile
communication conditions were perceived as better at enhancing state self-esteem and
alleviating distress compared to the no supportive tactile communication conditions
by observers. However, these main effects were qualified by significant two-way
interactions between message content and nonverbal behavior on ratings of state
self-esteem and distress alleviation, such that the addition of supportive tactile
communication enhanced the effectiveness of HPF message content but not HEF
content.
Assessment of Lignin Residues from Bioethanol Production of Olive Stones as Green Chemical Thickener of Epoxidized Linseed Oil
Authors: Cortés-Triviño E. , Valencia C. , Franco J. M. , Oliva J. M. , Manzanares P. , Eugenio M. E. , Ibarra D. 
Published: April 2024

AbstractThis work focused on the characterization of lignin residues from bioethanol production of olive stones (OS) and the use of these residues to chemically thicken epoxidized linseed oil (ELO). OS were processed by an acid/steam explosion pretreatment, followed by pre-saccharification, using different enzyme dosages, and simultaneous saccharification and fermentation. The chemical composition of the OS lignin residues was analysed, revealing a high lignin content (66.6–69.5%), and lower quantities of glucan (17.4–19.3%) and xylan (2.8–2.9%). Whereas, the structural properties of OS lignin residues were characterized by Fourier-transform infrared (FTIR) spectroscopy, nuclear magnetic resonance (NMR), thermogravimetric analysis and size exclusion chromatography (SEC). OS lignin residues displayed the main inter-unit linkages (β–β′ resinol (51.0–59.0%), followed by β-O-4′ alkyl aryl ethers (27.0–35.2%) and β-5′ phenylcoumaran (11.4–13.2%) substructures), high molecular weights (22,000–25900 Da), low S/G ratios (1.2–1.5) and phenolic groups content (48–55 mg GAE/g lignin). Moreover, OS lignin residues were dispersed in ELO to obtain thickened formulations, which were characterized by FTIR and NMR. Oil thickening was achieved by promoting the chemical crosslinking between lignocellulose hydroxyl groups and ELO epoxy groups, enabling the compatibilization of both components. Up to tenfold viscosity increment of the resulting thickened formulations in relation to ELO’s viscosity was observed. Besides, thickened formulations exhibited viscoelastic properties, evincing oil structuration to some extent.
Graphical Abstract
Computing parametrised large intersection sets of 1D invariant manifolds: a tool for blender detection
Authors: C’Julio Dana , Krauskopf Bernd , Osinga Hinke M. 
Published: April 2024

AbstractA dynamical system given by a diffeomorphism with a three-dimensional phase space may have a blender, which is a hyperbolic set $$\Lambda $$
Λ
with, say, a one-dimensional stable invariant manifold that behaves like a surface. This means that the stable manifold of any fixed or periodic point in $$\Lambda $$
Λ
weaves back and forth as a curve in phase space such that it is dense in some projection; we refer to this as the carpet property. We present a method for computing very long pieces of such a one-dimensional manifold so efficiently and accurately that a very large number of intersection points with a specified section can reliably be identified. We demonstrate this with the example of a family of Hénon-like maps $$\mathcal {H}$$
H
on $$\mathbb {R}^3$$

R

3

, which is the only known, explicit example of a diffeomorphism with proven existence of a blender. The code for this example is available as a Matlab script as supplemental material. In contrast to earlier work, our method allows us to determine a very large number of intersection points of the respective one-dimensional stable manifold with a chosen planar section and render each as individual curves when a parameter is changed. With suitable accuracy settings, we not only compute these parametrised curves for the fixed points of $$\mathcal {H}$$
H
over the relevant parameter interval, but we also compute the corresponding parametrised curves of the stable manifolds of a period-two orbit (with negative eigenvalues) and of a period-three orbit (with positive eigenvalues). In this way, we demonstrate that our algorithm can handle large expansion rates generated by (up to) the fourth iterate of $$\mathcal {H}$$
H
.
Chitosan-based delivery of fish codon-optimised Caenorhabditis elegans FAT-1 and FAT-2 boosts EPA and DHA biosynthesis in Sparus aurata
Authors: Wu Yuanbing , Rashidpour Ania , Fàbregas Anna , Almajano María Pilar , Metón Isidoro 
Published: April 2024

AbstractOmega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) are essential fatty acids required in healthy balanced diets for humans. To induce sustained production of n-3 LC-PUFA in gilthead seabream (Sparus aurata), chitosan-tripolyphosphate (TPP) nanoparticles encapsulating plasmids expressing fish codon-optimised Caenorhabditis elegans FAT-1 and FAT-2 were intraperitoneally administered every 4 weeks (3 doses in total, each of 10 μg plasmid per g of body weight). Growth performance and metabolic effects of chitosan-TPP complexed with pSG5 (empty plasmid), pSG5-FAT-1, pSG5-FAT-2 and pSG5-FAT-1 + pSG5-FAT-2 were assessed 70 days post-treatment. Tissue distribution analysis showed high expression levels of fish codon-optimised FAT-1 and FAT-2 in the liver (> 200-fold). Expression of fat-1 and fat-1 + fat-2 increased weight gain. Fatty acid methyl esters assay revealed that co-expression of fat-1 and fat-2 increased liver production and muscle accumulation of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and total n-3 LC-PUFA, while decreased the n-6/n-3 ratio. Co-expression of fat-1 and fat-2 downregulated srebf1 and genes encoding rate-limiting enzymes for de novo lipogenesis in the liver, leading to decreased circulating triglycerides and cholesterol. In contrast, FAT-2 and FAT-1 + FAT-2 upregulated hepatic hnf4a, nr1h3 and key enzymes in glycolysis and the pentose phosphate pathway. Our findings demonstrate for the first time efficient and sustained production of EPA and DHA in animals after long-term treatment with chitosan-TPP-DNA nanoparticles expressing FAT-1 and FAT-2, which enabled the production of functional fish rich in n-3 LC-PUFA for human consumption.
Not So Blue to be Sad: Affective Affordances and Expressive Properties in Affective Regulation
Authors: Caravà Marta , Benenti Marta 
Published: April 2024

AbstractIn our everyday interaction with the environment, we often perceive objects and spaces as opportunities to feel, maintain, enhance, and change our affective states and processes. The concept of affective affordance was coined to accommodate this aspect of ordinary perception and the many ways in which we rely on the material environment to regulate our emotions. One natural way to think of affective affordances in emotion regulation is to interpret them as tools for regulating felt affective states. We argue that this way of conceiving of affective affordances is too restrictive. By analyzing the role of expressive properties of objects and spaces in emotion regulation, we show that our environment does not need to elicit felt affective states to regulate our emotions. Thus, we revise the concept of affective affordance to accommodate these cases. This revised concept explains more with less. Hence, it should be preferred in wide-reaching philosophical projects that aim to explain human affectivity as a situated phenomenon.
In Vivo Labeling and Detection of Circulating Tumor Cells in Mice Using OTL38
Authors: Pace Joshua , Lee Jane J. , Srinivasarao Madduri , Kallepu Shivakrishna , Low Philip S. , Niedre Mark 
Published: April 2024

Abstract
Purpose
We recently developed an optical instrument to non-invasively detect fluorescently labeled circulating tumor cells (CTCs) in mice called ‘Diffuse in vivo Flow Cytometry’ (DiFC). OTL38 is a folate receptor (FR) targeted near-infrared (NIR) contrast agent that is FDA approved for use in fluorescence guided surgery of ovarian and lung cancer. In this work, we investigated the use OTL38 for in vivo labeling and detection of FR + CTCs with DiFC.

Procedures
We tested OTL38 labeling of FR + cancer cell lines (IGROV-1 and L1210A) as well as FR- MM.1S cells in suspensions of Human Peripheral Blood Mononuclear cells (PBMCs) in vitro. We also tested OTL38 labeling and NIR-DIFC detection of FR + L1210A cells in blood circulation in nude mice in vivo.

Results
62% of IGROV-1 and 83% of L1210A were labeled above non-specific background levels in suspensions of PBMCs in vitro compared to only 2% of FR- MM.1S cells. L1210A cells could be labeled with OTL38 directly in circulation in vivo and externally detected using NIR-DiFC in mice with low false positive detection rates.

Conclusions
This work shows the feasibility of labeling CTCs in vivo with OTL38 and detection with DiFC. Although further refinement of the DiFC instrument and signal processing algorithms and testing with other animal models is needed, this work may eventually pave the way for human use of DiFC.
Assessing the feasibility and sustainability of a surfactin production process: a techno-economic and environmental analysis
Authors: Poveda-Giraldo Johnny Alejandro , Solarte-Toro Juan Camilo , Treinen Chantal , Noll Philipp , Henkel Marius , Hausmann Rudolf , Cardona Alzate Carlos Ariel 
Published: April 2024

AbstractBiosurfactants have been profiled as a sustainable replacement for chemical-based surfactants since these bio-based molecules have higher biodegradability. Few research papers have focused on assessing biosurfactant production to elucidate potential bottlenecks. This research aims to assess the techno-economic and environmental performance of surfactin production in a potential scale of 65m3, considering different product yields and involving the European energy crisis of 2021–2022. The conceptual design, simulation, techno-economic, and environmental assessments were done by applying process engineering concepts and software tools such as Aspen Plus v.9.0 and SimaPro v.8.3.3. The results demonstrated the high economic potential of surfactin production since the higher values in the market offset the low fermentation yields, low recovery efficiency, and high capital investment. The sensitivity analysis of the economic assessment elucidated a minimum surfactin selling price between 29 and 31 USD/kg of surfactin, while a minimum processing scale for economic feasibility between 4 and 5 kg/h is needed to reach an equilibrium point. The environmental performance must be improved since the carbon footprint was 43 kg CO2eq/kg of surfactin. The downstream processing and energy demand are the main bottlenecks since these aspects contribute to 63 and 25% of the total emissions. The fermentation process and downstream process are key factors for future optimization and research.
Association Between Preconception Maternal Mental Health-Related Hospitalisation (MHrH) and Outcomes During Pregnancy: A Population-Based Cohort Study in the Northern Territory, Australia
Authors: Dadi Abel F. , He Vincent , Alati Rosa , Hazell-Raine Karen , Hazell Philip , Brown Kiarna , Guthridge Steven 
Published: April 2024

AbstractComprehensive studies investigating the link between maternal hospitalisation for mental health conditions prior to pregnancy and adverse outcomes in pregnancy are scarce in Australia. We aimed to fill this gap by using 18 years of administratively linked data to inform early interventions. We linked the perinatal data from the year 1999 to 2017 to the hospital hospitalisation data to create a cohort of pregnant women aged 15 to 44 years who gave birth in the Northern Territory (NT). We used the International Classification of Disease 10th revision (ICD-AM-10) codes to locate women with mental health-related hospitalisation (MHrH) (exposure of interest) and the perinatal data to access pregnancy outcomes. We used the modified Poisson regression with robust standard error to estimate the risk of pregnancy outcomes associated with maternal MHrH in the 5 years prior to pregnancy. We calculated the adjusted population attributable fraction (aPAF) for valid associations. We used the E-value to assess the effect of potential confounding bias. Out of 69,890 pregnancies, ~ 67,518 were eligible and included in the analysis. We found a significant variation in the incidence of substance use and complications between Aboriginal and non-Aboriginal women and women with and without MHrH in the 5 years prior to pregnancy. After adjusting, 5 years of preconception hospitalisation for substance misuse was associated with a 31% (95%CI, 1.05, 1.63) increased risk of Intrauterine Growth Restriction (IUGR), a 60% (CI, 1.37, 1.86) increased risk of smoking and a 2.21 (CI, 1.98, 2.47) times increased risk of drinking during pregnancy in Aboriginal women; and a 17% increased risk of drinking (CI, 1.11, 1.23) in pregnancy in non-Aboriginal women. A significant proportion of smoking (aPAF = 14.7 to 37.4%), alcohol consumption (aPAF = 46.0 to 66.7%), and IUGR (aPAF = 23.6 to 38.5%) are attributed to maternal MHrH 5 years prior to pregnancy. Our findings are a ‘wake-up’ call for strengthening preconception care to reduce adverse outcomes of maternal MHrH prior to pregnancy.
Mathematical Models of Early Hepatitis B Virus Dynamics in Humanized Mice
Authors: Ciupe Stanca M. , Dahari Harel , Ploss Alexander 
Published: April 2024

AbstractAnalyzing the impact of the adaptive immune response during acute hepatitis B virus (HBV) infection is essential for understanding disease progression and control. Here we developed mathematical models of HBV infection which either lack terms for adaptive immune responses, or assume adaptive immune responses in the form of cytolytic immune killing, non-cytolytic immune cure, or non-cytolytic-mediated block of viral production. We validated the model that does not include immune responses against temporal serum hepatitis B DNA (sHBV) and temporal serum hepatitis B surface-antigen (HBsAg) experimental data from mice engrafted with human hepatocytes (HEP). Moreover, we validated the immune models against sHBV and HBsAg experimental data from mice engrafted with HEP and human immune system (HEP/HIS). As expected, the model that does not include adaptive immune responses matches the observed high sHBV and HBsAg concentrations in all HEP mice. By contrast, while all immune response models predict reduction in sHBV and HBsAg concentrations in HEP/HIS mice, the Akaike Information Criterion cannot discriminate between non-cytolytic cure (resulting in a class of cells refractory to reinfection) and antiviral block functions (of up to $$99\%$$

99
%

viral production 1–3 weeks following peak viral load). We can, however, reject cytolytic killing, as it can only match the sHBV and HBsAg data when we predict unrealistic levels of hepatocyte loss.
Frailty as an Effect Modifier in Randomized Controlled Trials: A Systematic Review
Authors: Yao Aaron , Gao Linhui , Zhang Jiajun , Cheng Joyce M. , Kim Dae Hyun 
Published: April 2024

Abstract
Background
The effect of clinical interventions may vary by patients’ frailty status. Understanding treatment effect heterogeneity by frailty could lead to frailty-guided treatment strategies and reduce overtreatment and undertreatment. This systematic review aimed to examine the effect modification by frailty in randomized controlled trials (RCTs) that evaluate pharmacological, non-pharmacological, and multicomponent interventions.

Methods
We searched PubMed, Web of Science, EMBASE, and ClinicalTrial.gov, from their inception to 8 December 2023. Two reviewers independently extracted trial data and examined the study quality with senior authors.

Results
Sixty-one RCTs that evaluated the interaction between frailty and treatment effects in older adults were included. Frailty was evaluated using different tools such as the deficit accumulation frailty index, frailty phenotype, and other methods. The effect of several pharmacological interventions (e.g., edoxaban, sacubitril/valsartan, prasugrel, and chemotherapy) varied according to the degree of frailty, whereas other treatments (e.g., antihypertensives, vaccinations, osteoporosis medications, and androgen medications) demonstrated consistent benefits across different frailty levels. Some non-pharmacological interventions had greater benefits in patients with higher (e.g., chair yoga, functional walking, physical rehabilitation, and higher dose exercise program) or lower (e.g., intensive lifestyle intervention, psychosocial intervention) levels of frailty, while others (e.g., resistance-type exercise training, moderate-intensive physical activity, walking and nutrition or walking) produced similar intervention effects. Specific combined interventions (e.g., hospital-based disease management programs) demonstrated inconsistent effects across different frailty levels.

Discussion
The efficacy of clinical interventions often varied by frailty levels, suggesting that frailty is an important factor to consider in recommending clinical interventions in older adults.

Registration
PROSPERO registration number CRD42021283051.
Arbeitsmarktteilhabe durch Qualifizierung? De‑, Dis- und Sonderqualifizierung geflüchteter Frauen im deutschen Berufsbildungssystem
Authors: Menke Katrin , Ullmann Johanna 
Published: April 2024

ZusammenfassungBerufliche Qualifizierung gilt international gemeinhin als Garant für nachhaltige Erwerbsarbeit von Geflüchteten. Seit der erhöhten Fluchtzuwanderung im Jahr 2015 hat sich das Feld beruflicher Qualifizierung in Deutschland erheblich ausdifferenziert. Trotz hoher Erwerbsambitionen und bestehender Qualifizierungsbedarfe landen geflüchtete Frauen bisher jedoch kaum in qualifizierter Erwerbsarbeit oder beruflicher Ausbildung. Dieser Beitrag bearbeitet den Zusammenhang zwischen beruflicher Qualifizierung und Arbeitsmarktsegmentierungen am Beispiel fluchtmigrierter Frauen in Deutschland, indem er segmentationstheoretische Ansätze und deren jüngeren feministisch-sozialkonstruktivistischen Erweiterungen auf das Berufsbildungssystem überträgt und mit empirischen Befunden unterfüttert. Anhand von qualitativem Interviewmaterial mit Akteur:innen in Arbeitsverwaltung und Trägerorganisationen von Arbeitsmarktintegrationsprojekten werden verschiedene Zuweisungspraxen rekonstruiert, die 1) aus symbolischen Auf- und Abwertungen beruflicher Qualifikationen bestehen und 2) durch Einschätzungen von (nicht) vorhandenen Qualifizierungsoptionen charakterisiert sind. Der Artikel illustriert, wie das Zusammenspiel aus geschlechtsspezifisch-rassifizierenden Zuschreibungen und der Strukturiertheit vorhandener Berufsbildungs- und Arbeitsmarktinstitutionen die Positionierung der Gruppe am unteren Ende der Arbeitsmarkt- und Ausbildungshierarchie nach sich zieht. In der Folge erfahren geflüchtete Frauen eine Zuweisung in Richtung De‑, Dis- oder Sonderqualifizierung, die in unqualifizierte, prekäre (feminisierte und migrantisierte) Anlern- und Hilfsjobs auf dem segmentierten Arbeitsmarkt kanalisiert und eine unsichere berufs- und ausbildungsvorbereitende Übergangsphase der Gruppe verlängert. Der Beitrag beleuchtet damit die bislang wenig erforschte Frage, was als berufliche Qualifikation und insofern förderliche Qualifizierung im Kontext von Flucht gilt (oder nicht). Aufgrund gegenwärtiger Ausbaupläne beruflicher Weiterqualifizierung in Deutschland nach österreichischem Vorbild ist dies eine zunehmend relevante Frage.
Achieving a Columnar-to-Equiaxed Transition Through Dendrite Twinning in High Deposition Rate Additively Manufactured Titanium Alloys
Authors: Davis A. E. , Wainwright J. , Sahu V. K. , Dreelan D. , Chen X. , Ding J. , Flint T. , Williams S. , Prangnell P. B. 
Published: April 2024

AbstractThe coarse β-grain structures typically found in titanium alloys like Ti–6Al–4V (wt pct, Ti64) and Ti–6Al–2Sn–4Zr–2Mo–0.1Si (Ti6242), produced by high deposition rate additive manufacturing (AM) processes, are detrimental to mechanical performance. Certain modified processing conditions have been shown to lead to a more refined grain structure, which has generally been attributed to a change in the solidification conditions with respect to the experimental Hunt diagram proposed by Semiatin and Kobryn. It is shown that with Wire Arc AM (WAAM) increasing the wire feed speed (WFS) is effective in promoting a columnar-equiaxed transition (CET). Conversely, estimates of the dendrite-tip undercooling using the KGT model suggest that this will be too small for free nucleation without the addition of artificial nucleants, due to the very low solute partitioning in Ti alloys. It is also shown that it is difficult to promote a CET with plasma transferred arc WAAM as computational fluid dynamics (CFD) melt-pool simulations indicate that the solidification parameters remain within the columnar region on the Semiatin-Kobryn Hunt map, within the constraints of a stable process. However, a high fraction of twin boundaries was observed in the refined β-grain structures seen at high WFS. This has been attributed to departure of $$\left\langle {001} \right\rangle _{\beta }$$

001

β

alignment from the direction of maximum thermal gradient, caused by the curvature of the fusion boundary, stimulating dendrite twinning during solidification. In addition, it is shown that increasing the WFS leads to a change in melt-pool geometry and a reduction of remelt depth, which promoted dendrite twinning and grain refinement.
Overexpression of α-Klotho isoforms promotes distinct Effects on BDNF-Induced Alterations in Dendritic Morphology
Authors: Cararo-Lopes Marina Minto , Sadovnik Ratchell , Fu Allen , Suresh Shradha , Gandu Srinivasa , Firestein Bonnie L. 
Published: April 2024

Abstractα-Klotho (α-Kl) is a modulator of aging, neuroprotection, and cognition. Transcription of the Klotho gene produces two splice variants—a membrane protein (mKl), which can be cleaved and released into the extracellular milieu, and a truncated secreted form (sKl). Despite mounting evidence supporting a role for α-Kl in brain function, the specific roles of α-Kl isoforms in neuronal development remain elusive. Here, we examined α-Kl protein levels in rat brain and observed region-specific expression in the adult that differs between isoforms. In the developing hippocampus, levels of isoforms decrease after the third postnatal week, marking the end of the critical period for development. We overexpressed α-Kl isoforms in primary cultures of rat cortical neurons and evaluated effects on brain-derived neurotrophic factor (BDNF) signaling. Overexpression of either isoform attenuated BDNF-mediated signaling and reduced intracellular Ca2+ levels, with mKl promoting a greater effect. mKl or sKl overexpression in hippocampal neurons resulted in a partially overlapping reduction in secondary dendrite branching. Moreover, mKl overexpression increased primary dendrite number. BDNF treatment of neurons overexpressing sKl resulted in a dendrite branching phenotype similar to control neurons. In neurons overexpressing mKl, BDNF treatment restored branching of secondary and higher order dendrites close, but not distal, to the soma. Taken together, the data presented support the idea that sKl and mKl play distinct roles in neuronal development, and specifically, in dendrite morphogenesis.