bluuebunny/crossref_metadata_2025_split huggingface dataset:
La cocréation de valeur sur Facebook : cas des enseignes de restauration rapide
Authors: Hassouni Mohammed , Chakor Abdellatif 
Published: March 2024

Cet article a pour objectif de déterminer les principaux facteurs qui influencent la cocréation de valeur sur les pages Facebook d’enseigne de restauration rapide au Maroc. Le modèle utilisé est inspiré des modèles DART et TAM. Un questionnaire administré a été envoyé en ligne à 384 personnes et a été traité selon la méthode PLS.	Toutes les variables du modèle PLS ont prédit la cocréation de valeur. Le dialogue, l’accès à l’information, la gestion des risques, la transparence et l’utilité perçue ont influencé la cocréation de valeur. Un échantillon de convenance a été utilisé puisque des étudiants ont été interrogés. L’étude pourrait être reconduite avec d’autres types de cibles et de réseaux sociaux. La finalité managériale de ce travail serait de poser les questions stratégiques sur le community management dans le secteur de la restauration rapide.
Les transformations de la pensée de Marx sur la colonisation
Authors: Herrera Rémy 
Published: March 2024

Cet article analyse les évolutions des positions de Marx à propos de la colonisation. Il souligne tout d’abord l’invariant de ces réflexions : la dénonciation de la violence coloniale. Au départ, on trouve une interprétation de la colonisation comme processus de modernisation, puis comme dynamique de destruction-régénération, liée à l’« unification du monde ». L’auteur identifie spécialement les inflexions successives de la pensée de Marx – résolument critique –, au sujet des questions coloniale et nationale, du caractère non linéaire de l’histoire, mais aussi de la différenciation des formations sociales.
Retour sur « Les “nouveaux” métiers des quartiers populaires », au prisme des rapports sociaux de classe, de genre et de race
Authors: Lebon Francis 
Published: March 2024

Dans le prolongement de mes recherches sur les professionnels de l’éducation populaire (Lebon, 2020), cette note de lecture reprend, complète et développe un article publié il y a trente ans par Dominique Glasman et Jacques Ion sur les « nouveaux » métiers impulsés par l’éducation prioritaire et la politique de la ville 1 . Elle réexamine une polarité qui traverse le travail dans les quartiers populaires. D’un côté, les « institutions », les « secteurs » et le « professionnalisme » ; de l’autre, l’» enracinement », le « territoire » et le « militantisme ». Elle la complète par l’hypothèse d’une lutte des classements dans les mondes de l’éducation et du travail social qui oppose deux fractions de classe : d’un côté, des classes moyennes salariées ; de l’autre, des classes populaires précarisées et racisées. Elle engage ainsi une réflexion sur les rapports sociaux et le travail (des femmes) dans les services publics.
Pensée réflexive et usage des concepts « psy » en crèche : tensions et contradictions
Authors: Prado-Martin Renata , Valentim Silvia 
Published: March 2024

Souvent considérées comme de simples tâches domestiques ou comme un travail n’exigeant pour l’essentiel que des qualités affectives, les pratiques quotidiennes des professionnelles de la petite enfance sont pourtant complexes. Dans un cadre professionnel rempli de tensions, les références aux concepts « psy » trouvent une place centrale par le fait de correspondre, du moins théoriquement, aux attentes des projets d’établissement, et en étant ainsi légitimées dans un contexte complexe où le besoin de repères devient incontournable. Cet article s’appuie sur une recherche doctorale et sur des observations et réunions réalisées lors d’une expérience de psychologue dans trois structures de la petite enfance. Il met en débat et croise différentes dimensions : institutionnelles, micro et mésosociologiques. Avec cette démarche, nous tenterons d’illustrer la difficile articulation de ces dimensions, ainsi que leur interdépendance. L’analyse met en avant le besoin pour les professionnelles de la petite enfance d’avoir du temps pour analyser leur pratique auprès des jeunes enfants, afin d’identifier et rendre visible toute la complexité et l’importance sociale de leur travail ; les concepts « psy » ou le « psy » du service viennent alors remplir l’espace laissé par le manque de temps de réflexion, sans nécessairement de lien réel avec le quotidien des professionnelles et des enfants. L’urgence dans laquelle se trouvent les professionnelles de la petite enfance semble aller à l’encontre d’un raisonnement cherchant à prendre en compte les transformations institutionnelles du secteur d’activité, la temporalité et le rythme réels des enfants accueillis.
Le Malade imaginaire « médicalement » informé de Molière
Authors: Bouffard Mickaël 
Published: March 2024

En prenant comme point de départ la mise en scène du Malade imaginaire par le Théâtre Molière Sorbonne en 2022, cet article détaille comment une démarche historiquement informée, inspirée des méthodes de l’archéologie expérimentale et de l’interprétation de la musique ancienne, puise dans les savoirs et usages médicaux du XVIIe siècle pour révéler des effets comiques et jeux de théâtre vraisemblablement imaginés par Molière. Une quantité de sources très variées sont croisés pour parvenir à cette fin : artefacts, archives comptables, traités, statuts cérémoniels, peintures, dessins, gravures, ego-documents et autres témoignages écrits contemporains de la création de la pièce. Les pratiques, instruments et représentations culturels entourant l’acte médical du lavement font l’objet d’une étude de cas plus approfondie.
Les réformés vus par le cardinal Guido Bentivoglio (1577-1644)
Authors: Negruzzo Simona 
Published: March 2024

C’est à la suite de l’assemblée générale des réformés tenue à Loudun en 1619 que le cardinal Guido Bentivoglio, nonce auprès le roi de France, envoie à l’attention du cardinal-neveu Scipione Borghese une relation sur l’organisation des Églises huguenotes. Le texte, désormais disparu dans sa version originale, est aujourd’hui connu grâce à une version imprimée liégeoise publiée en 1635 et quelques rares copies manuscrites, dont celle conservée à la Bibliothèque nationale et universitaire de Strasbourg. Il s’agit d’une source importante qui décrit à destination de la curie romaine la situation d’un royaume où, après l’édit de Nantes, deux Églises chrétiennes sont obligées de coexister, sans toutefois que les tensions déclenchées par les guerres de Religion aient complètement disparu.
Multifocal musculoskeletal tuberculosis in an immunocompetent Iraqi patient
Authors: Alhayali Mustafa Mohanad , Shihab Sami Salman 
Published: March 2024

Abstract:
Musculoskeletal tuberculosis (TB) is an ancient disease; features of spinal TB have been identified in Egyptian mummies dating back 9000 years. It accounts for 10%–35% of cases of extrapulmonary TB. The occurrence of noncontiguous, multifocal musculoskeletal TB in immunocompetent persons is rare even in countries which are endemic in TB. Here, we present a case of multifocal musculoskeletal TB involving multiple levels of the spine and a peripheral joint. A 25-year-old female from Baghdad presented to us with inflammatory back pain for 9 months. She had a negative medical history. Initially, she was treated as a case of pyogenic discitis based on her magnetic resonance imaging results and high inflammatory markers; she was given antibiotics without clinical improvement. Later on, she developed pleural effusion with new painful swelling in her left ankle joint. Aspiration of the left ankle joint was performed, and a biopsy was taken and sent for a TB-DNA polymerase chain reaction test, which was positive, leading to the final diagnosis of musculoskeletal TB. The correct diagnosis of musculoskeletal TB is clinically challenging and difficult, especially when there are multilevel lesions. Our findings indicate that multiple tuberculous lesions must be considered in the differential diagnosis of multiple musculoskeletal lesions, especially in endemic areas such as Iraq.
Stereotypy and parkinsonism in tubercular meningitis: Expanding the spectrum
Authors: Jha Shreyashi , Tiwari Mona , Chatterjee Debarshi , Datta Ashis , A Shobhana 
Published: March 2024

Abstract
Movement disorders associated with tubercular meningitis have been reported, ranging from tremors to chorea. Stereotypy is a rare manifestation following tubercular meningitis. Here we report a rare case of a 29-year-old man who developed stereotypy and parkinsonism following tubercular meningitis. The stereotypy was in the form of rotatory movements of the right upper limb, which were repetitive, purposeless, non-goal directed, present for most of the day, and partially suppressible. In addition, it was associated with severe generalized parkinsonism. This report expands the spectrum of movement disorders seen in tubercular meningitis.
Khat consumption as a modifiable risk factor for chewing dystonia
Authors: Mehta Anish , Dugani Pooja , Rangaiah Pradeep , Javali Mahendra , Acharya Purshottam , Srinivasa Rangasetty 
Published: March 2024

Abstract
Chewing dystonia, a variant of focal task-specific dystonia, is a rarely reported condition that causes remarkable decrement in quality-of-life, social embarrassment, and associated mental stress. In this article, we present two case studies that extend previous observations, which indicate a putative association between khat (Catha edulis) consumption and chewing dystonia. While pharmacological treatments such as botulinum toxin injections may be an option, a substantial proportion of affected individuals do not achieve optimal outcomes. If preventable, a medical condition ought to be prevented. The observations presented in the two case studies discussed indicate that khat consumption may be a modifiable risk factor for chewing dystonia.
ADCY5-related dyskinesias: An amalgamation of various hyperkinetic movement disorders
Authors: Khandelwal Dinesh , Pemassini Neha , Pemawat Ashish , Mathur Vaibhav 
Published: March 2024

Abstract
Adenylyl cyclase 5 (ADCY5)-related dyskinesia is a rare disorder characterized by early-onset paroxysmal choreoathetosis, dystonia, myoclonus, or a combination thereof, primarily involving the limbs, face, and neck. Other core clinical features include nocturnal ballistic bouts and facial dyskinesias, often followed by remission during adolescence, as well as axial hypotonia. Any mixed movement disorder accompanied by the aforementioned core features should prompt genetic testing for ADCY5 mutation.
We report the case of a 31-year man from North India with a childhood-onset history of clumsy, random, and jerky body and facial movements, interfering with his speech and object-handling and walking-related functional abilities. He improved symptomatically with zonisamide and was offered caffeine as a maintenance option. Here, we review the literature on this entity, while reporting this first case of ADCY5-related dyskinesias from North India.
The phenotypic spectrum linked to ADCY5 mutations has significantly broadened since its initial description in a family with “familial dyskinesia and facial myokymia.” This phenotypic variability could be responsible for a proportion of “idiopathic” hyperkinetic movement disorders. Gaining a better understanding of its clinical manifestations helps in identifying complex or uncommon cases more effectively.
LGI1 encephalitis–Behaviors predate movements: A case series
Authors: Venkateswaran Poornam N , Gopalan Balaji , S. Hariharan 
Published: March 2024

Abstract
Anti-leucine-rich, glioma-inactivated (LGI1) autoimmune encephalitis is one of the autoimmune encephalitides with a distinct movement abnormality – faciobrachial dystonic seizures (FBDS). FBDS, being the clinching sign towards a clinical diagnosis, is known to occur at disease onset, and if left untreated, can lead to disabling cognitive impairment. In this case series, we describe three cases of LGI1 encephalitis presenting with behavioral abnormalities at onset for a significant period, compelling an alternative diagnosis preceding the onset of FBDS. In addition, it highlights that imaging could be normal in the initial stages of the disease, further making the diagnosis a challenge at an initial stage.
Unveiling the Antimicrobial Potential of 7-O-succinyl Macrolactin F from Bacillus subtilis Group against HtsA Siderophore Receptor of Staphylococcus aureus: A Computational Exploration
Authors: Kalai Keshinee , Rufus Adeline Celina , Manz Ardra Mariam , Elangovan Elavarashi 
Published: March 2024

Background:

Staphylococcus aureus remains a prominent pathogen within health-care environments due to its extensive repertoire of virulence factors. The escalating prevalence of antibiotic-resistant strains has underscored the urgency of identifying alternative treatment strategies. The study focuses on the HtsA siderophore receptor, an integral cell wall component of all S.
aureus strains, responsible for iron acquisition from the host environment. Here, we investigate the potential of Bacillus sp. derived macrolides as inhibitors of this critical iron uptake mechanism.

Methods:
Sixteen distinct macrolide ligands were evaluated for their ability to disrupt iron acquisition by S.
aureus through interaction with the HtsA receptor. Employing molecular docking and subsequent molecular dynamics (MDs) simulations, the binding interactions and dynamic behaviors of these ligands with the receptor were assessed.

Results:
Notably, the complex formed between 7-O-succinyl macrolactin F and HtsA demonstrated a good binding affinity of − 8.5 kcal/mol, outperforming the binding affinity of staphyloferrin A, which exhibited a binding affinity of − 6.9 kcal/mol. MD simulations further corroborated the stability of the 7-O-succinyl macrolactin F-HtsA complex over time, suggesting the potential for this interaction to be harnessed as a novel therapeutic strategy not only for existing antibiotic-resistant strains but also for those that may arise in the future.

Conclusion:
The findings propose Bacillus species-derived macrolides as potential adjuvant therapies for S.
aureus infections, pending comprehensive safety assessments. This research lays the foundation for the development of innovative antimicrobial agents targeting essential virulence-associated mechanisms in S.
aureus.
Unraveling Epigenetic Signatures for Early Detection of Diabetes Nephropathy in Type 2 Diabetes: A Case–Control Investigation
Authors: Chahar Deeksha , Sonkar Gyanendra Kumar , Singh Sangeeta , Sonkar Satyendra Kumar , Ahmad Mohammad Kaleem 
Published: March 2024

Background:
Type 2 diabetes mellitus (T2DM) leads to a substantial elevation in the occurrence of various micro- and macrovascular complications. Approximately one-third of patients of both type 1 diabetes and T2DM develop diabetes nephropathy (DN). Emerging findings in epigenetic modifications indicate that differences in DNA methylation patterns could have a more substantial impact when assessing the susceptibility to type 2 diabetes mellitus (T2DM) in contrast to genetic variations.

Methods:
The study involved 298 participants, encompassing 75 individuals with type 2 diabetes mellitus (T2DM), 74 individuals with diabetes nephropathy (DN), and 149 healthy control subjects aged between 20 and 70 years. The concentrations of circulating adiponectin, insulin-like growth factor (IGF) 1, and IGF2 were quantified using enzyme-linked immunoassay. The amount of RNA in each sample (control, T2DM, and DN) was quantified, and its purity was checked using nanodrop. Real-time analysis of Adiponectin,
IGF1,
IGF2,
and
GAPDH genes was conducted using the SYBR Green polymerase chain reaction Master Mix assay.

Results:
Circulating levels of IGF1 level were significantly lower in both T2DM and DN, whereas it was slightly higher in T2DM than the DN. IGF2 circulating level was higher in both T2DM and DN as compared to control, whereas it was lower in T2DM when compared to DN. The gene expression level of adiponectin was reduced in both T2DM and DN when compared to the control group; however, it was higher in T2DM than in DN. The gene expression level of IGF1 was decreased in both T2DM and DN compared to the control group, with a more significant decrease in DN compared to T2DM.

Conclusion:
The measurement of circulatory levels of adiponectin, IGF1, and IGF2 in serum, along with gene expression analysis, provides valuable insights for predicting the progression from T2DM to DN. Consequently, these markers hold the potential to enhance early diagnosis, guide treatment strategies, and serve as innovative prognostic indicators for DN diagnosis.
Biological Signaling Network in Myocardial Infarction in Young Adults. A Study of Transcriptome Analysis
Authors: Kaulgud Ram S. , Vanti Gulamnabi L. , Veeresh S. , Uppar Amruta P. , Kurjogi Mahantesh M. 
Published: March 2024

Background:Myocardial infarction (MI) is the common manifestation of coronary heart disease that develops from occlusion of coronary arteries. Several risk factors of MI were identified, but data pertaining to genetics and molecular mechanisms involved in the development of MI is limited. Therefore, the present study attempts to analyze the peripheral blood transcriptome information of MI patients and unveil the key genes involved in the pathogenesis of MI.Methods:Total RNA was extracted from the blood sample for illumine sequencing, and raw data obtained were subjected to quality control (QC) using the FastQC tool, followed by trimming of raw data by the fastp tool. Further processed high-quality data were aligned onto the human reference genome using HISAT2 aligner. Gene quantification was done using the feature Counts plugin in the subread package. The raw read counts were given as input to the differential expression analysis (DESeq2) R package for the computation of differentially expressed genes. Gene set enrichment analysis for gene ontology was done using the clusterProfiler R package.Results:A total of 609 genes were significantly expressed in the present study, of which 561 genes were upregulated and 48 genes were downregulated. This study presents overall changes in genes involved in different categories such as biological processes, molecular functions, and cellular components in responses to MI.Conclusions:The significantly deregulated genes identified in the present study not only indicate the molecular and cellular changes but also suggest the scope for the detection of specific gene markers for MI.
Potential Protective Effect of Anti-zinc Transporter 8 Autoantibodies on Gestational Diabetes Mellitus in Iraqi Population
Authors: Alrikabi Rihab Mohammed , Hussain Da’ad Ali 
Published: March 2024

Background:The human zinc transporter 8 (ZNT8), also known as the solute carrier family 30A, member 8 (SLC30A8), is a β-cell specific integral membrane protein, mainly restricted to the membrane of insulin secretory granules. ZnT8 plays a crucial role in both insulin synthesis and secretion as well as the viability of β-cells. The recently identified autoantibodies targeting the β-cell surface epitopes of ZnT8 have been proposed as a new risk factor for gestational diabetes mellitus (GDM). Due to the lack of prior research studies on the role of β-cell surface autoantibodies against ZnT8 in the immunologic etiology of GDM in Iraqi population, this study has been designed to explore the association between the rs13266634 C>T polymorphism in the SLC30A8 gene and the serum levels of ZnT8 as well as Zinc Transporter-8 Autoantibody (ZnT8A) in women diagnosed with GDM.Methods:A total of 50 participants with GDM and 50 controls from the Baghdad Teaching Hospital/Pregnancy Care unit at the Medical City, Baghdad, Iraq, were recruited in this case–control study. Serum levels of ZnT8 and ZnT8A were assayed with enzyme-linked immunosorbent assay, and Taqman real time polymerase chain reaction (RT-PCR) was used for rs13266634 single nucleotide polymorphism (SNP) genotyping.Results:ZnT8A levels were significantly lower in women with GDM than non-GDM women (P≤ 0.01). A ZnT8A level lower than 20.0 pg/mL was significantly associated with a threefold higher risk for GDM withP≤ 0.001. ZnT8 levels were significantly higher in the GDM subjects (P≤ 0.05). The T allele at the rs13266634 C>T SNP significantly conferred a higher risk of GDM (P= 0.002). In view of that, the TT genotype, compared to the CC genotype, showed a significant association with increased GDM risk (P≤ 0.01). Serum ZnT8A concentrations were significantly low among GDM women who had CT genotype (P= 0.003).Conclusion:The T variant at the SLC30A8 rs13266634 C>T polymorphism appears to play a key role in determining the β-cell autoimmunity by inducing an autoantibody response due to its hyperactivity of zinc transportation.
Application of a New Protocol for a Study of Colonic Transit Using Radiopaque Markers in Functional Constipation for a Population with Rapid Gut Transit
Authors: Remalayam Bhavith , Thomas Varghese 
Published: March 2024

Abstract

Background:
Indians do not fit the definition of slow transit constipation (STC) according to Western standards because of their quick gut transit. The colonic transit study (CTS) can discriminate between patients with severe specific motility problems, such as Hirschsprung’s disease and chronic intestinal pseudo-obstruction, and healthy participants with optimal sensitivity and specificity when using a new technique in the Indian population. The study’s goal was to establish the appropriate cutoff to distinguish between healthy participants and moderate abnormalities such as functional constipation. The study aimed to find out a cutoff value for STC compared to healthy volunteers in the Indian population using the new Indian protocol of CTS.

Materials and Methods:
This observational study was performed in the department of gastroenterology from August 2014 to February 2015. Twenty-one patients who fulfilled the criteria for Rome III functional constipation and eight healthy sex-matched volunteers were included in the study. Subjects were instructed to take 4, 3, and 3 capsules simultaneously (6 markers in each capsule) at 0, 12, and 24 h, respectively. An abdominal X-ray was taken at 36 h and 60 h. The patient group also underwent a thorough history, a clinical examination, and a balloon expulsion test as a screening test for fecal evacuation disorder. The data were compiled and analyzed. The best cutoff was determined by a receiver operating characteristic curve, and the sensitivity, specificity, and predictive values were determined.

Results:
There were a total of 21 patients with 14 males and 7 females. The majority (38.1%) had a frequency of 7/week. The predominant symptoms were hard stool (66.7%), sensation of blockage (85.7%), and straining (90.5%). The best cutoff to differentiate between normal and slow transit, in comparison to healthy volunteers, was calculated. Area under curve was computed to be 0.69 (P = 0.001) for 60 h and 0.71 (P = 0.001) for 36 h. When ≥4 and ≥1 markers were taken, the sensitivity and specificity were 100% and 25%, respectively. When ≥20 and ≥4 markers were taken, the sensitivity and specificity were 52% and 100%, respectively. No significant difference between right, left, or rectosigmoid segmental colonic transit time was found at 36 or 60 h.

Conclusion:
The new protocol to assess colonic transit in the Indian population with functional constipation may be used as a screening modality to find out the delayed transit constipation. However, this protocol has less sensitivity, specificity, and positive and negative predictive values for functional constipation compared to severe diseases such as Hirschsprung’s disease and colonic pseudoobstruction.