bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiation treatment for incompletely resected soft-tissue sarcomas in dogs
Authors: McKnight Josephine A. , Mauldin G. Neal , McEntee Margaret C. , Meleo Karelle A. , Patnaik Amiya K. 
Published: December 2005

AbstractObjective—To evaluate efficacy of radiation for treatment of incompletely resected soft-tissue sarcomas in dogs.Design—Prospective serial study.Animals—48 dogs with soft-tissue sarcomas.Procedure—Tumors were resected to < 3 cm3prior to radiation. Tumors were treated on alternate days (three 3-Gy fractions/wk) until 21 fractions had been administered. Cobalt 60 radiation was used for all treatments.Results—Five-year survival rate was 76%, and survival rate was not different among tumor types or locations. Four (8%) dogs developed metastases. Eight (17%) dogs had tumor recurrence after radiation. Development of metastases and local recurrence were significantly associated with reduced survival rate. Median survival time in dogs that developed metastases was 250 days. Median disease-free interval for all dogs was 1,082 days. Median time to recurrence was 700 days. Dogs that developed recurrence after a prolonged period responded well to a second surgery. Acute radiation toxicosis was minimal; osteosarcoma developed at the radiation site in 1 dog.Conclusion and Clinical Relevance—An excellent long-term survival rate may be achieved by treating soft-tissue sarcomas in dogs with resection followed by radiation. Amputation is not necessary for longterm control of soft-tissue sarcomas in limbs. Development of metastases and recurrence of local tumors after radiation treatment are associated with decreased survival rate. Acute and delayed radiation toxicosis was minimal with the protocol used in this study. (JAm Vet Med Assoc2000;217:205–210)
Eclampsia in dogs: 31 cases (1995–1998)
Authors: Drobatz Kenneth J. , Casey Kim K. 
Published: December 2005

AbstractObjective—To compare clinical characteristics and laboratory findings of dogs with eclampsia with those of dogs without eclampsia.Design—Retrospective study.Animals—31 dogs with eclampsia (affected) and 31 with dystocia (controls).Procedure—Information on signalment, type of diet, reproductive history, litter size, time from whelping to eclampsia, body weight, clinical signs, results of physical examination and hematologic and biochemical analyses, response to calcium supplementation, and reccurrence was obtained from the medical records of all dogs with eclampsia evaluated between 1995 and 1998 and compared with information from medical records of 31 of 102 dogs with dystocia evaluated during the same period.Results—Dogs with eclampsia weighed less, had a smaller body weight-to-litter size ratio, higher rectal temperature and heart and respiratory rates, and lower plasma total solids concentration than control dogs. Ionized calcium concentration was ≤ 0.8 mmol/L for all but 1 of the affected dogs; median concentration for the affected dogs was significantly less than that for control dogs. Six (19%) dogs did not manifest typical clinical signs associated with eclampsia. Twelve (39%) dogs with eclampsia had previous litters; none had a history of eclampsia. Affected dogs were discharged from the hospital within hours after admission, but 3 dogs returned 1 to 3 weeks later because of recurrence of eclampsia.Conclusions and Clinical Relevance—Eclampsia develops primarily in small-breed dogs with large litters. Plasma ionized calcium concentrations > 0.8 mmol/L in dogs with clinical signs typical of hypocalcemia may indicate that other causes of clinical signs should be considered. In addition, some dogs with eclampsia may have low ionized calcium concentrations and not manifest typical clinical signs. (J Am Vet Med Assoc2000;217:216–219)
Fecal shedding of Salmonella spp by horses in the United States during 1998 and 1999 and detection of Salmonella spp in grain and concentrate sources on equine operations
Authors: Traub-Dargatz Josie L. , Garber Lindsey P. , Fedorka-Cray Paula J. , Ladely Scott , Ferris Kathy E. 
Published: December 2005

AbstractObjective—To estimate prevalence of fecal shedding ofSalmonellaspp among horses in the US horse population and prevalence ofSalmonellaspp in grain or other concentrate used as horse feed on equine operations in the United States.Design—Cross-sectional survey.Sample Population—Horses on 972 operations in 28 states.Procedure—Fecal samples were collected from horses resident at each operation. Only a single sample was collected from any individual horse; number of horses from which samples were collected on each operation was determined on the basis of number of horses on the operation. A single sample of grain or concentrate was also collected from each operation. All samples were tested forSalmonellaspp by means of bacterial culture.Results—Overall, 0.8% (SE, 0.5) of resident horses shedSalmonellaspp in their feces. The overall prevalence of operations positive for fecal shedding ofSalmonellaspp (ie, operations with ≥ 1 horse sheddingSalmonellaspp in its feces) was 1.8% (SE, 0.7). Prevalence of grain or other concentrate samples positive forSalmonellaspp was 0.4%. Serotypes ofSalmonellaspp that were identified in grain or other concentrate were not those typically associated with clinical disease in horses.Conclusions and Clinical Relevance—Results suggest that the national prevalence of fecal shedding ofSalmonellaspp by horses in the United States was 0.8%, and that prevalence ofSalmonellaspp in grain or other concentrate used for horse feed was 0.4%.(J Am Vet Med Assoc2000;217:226–230)
Arthroscopic removal of fracture fragments involving a portion of the base of the proximal sesamoid bone in horses: 26 cases (1984–1997)
Authors: Southwood Louise L. , McIlwraith C. Wayne 
Published: December 2005

AbstractObjective—To determine the outcome of horses with basal fractures of the proximal sesamoid bone from which a fracture fragment involving a portion of the base of the bone was removed arthroscopically and to determine whether fragment size was associated with outcome.Design—Retrospective study.Animals—26 horses.Procedure—Dorsopalmar and axial-abaxial lengths of the fracture fragment were measured on the dorsopalmar and mediolateral radiographic views, respectively, and percentage of the base of the sesamoid bone involved was estimated. Fractures were classified as grade 1 (≤ 25% of the base involved) or grade 2 (> 25% but < 100% of the base involved). Outcome was classified as successful if the horse started at least 2 races or unsuccessful if the horse started only 1 race or failed to return to racing.Results—There were 24 racehorses and 2 nonracehorses. Twelve (50%) of the racehorses returned to racing and started at least 2 races. Eight of 14 horses with grade-1 fractures and 4 of 10 horses with grade- 2 fractures had a successful outcome. Ten of 16 horses without associated articular disease had successful outcomes, compared with 2 of 8 horses with associated articular disease. However, fragment size and presence of associated articular disease were not significantly associated with outcome.Conclusions and Clinical Relevance—Horses with basal fractures of the proximal sesamoid bone from which a fracture fragment involving a portion of the base of the bone is removed arthroscopically have a fair prognosis for return to racing. (J Am Vet Med Assoc2000;217:236–240)
Heartworm infection in cats: 50 cases (1985–1997)
Authors: Atkins Clarke E. , DeFrancesco Teresa C. , Coats Julie R. , Sidley Jennifer A. , Keene Bruce W. 
Published: December 2005

AbstractObjective—To characterize risk factors, clinical findings, usefulness of diagnostic tests, and prognosis in cats with naturally occurring heartworm infection (HWI).Design—Retrospective study.Animals—50 cats withDirofilaria immitisinfection.Procedure—Medical records, thoracic radiographs, and echocardiograms were reviewed and findings compared with appropriate reference populations.Results—Findings suggested that male cats were not predisposed to HWI, domestic shorthair cats were at increased risk, and indoor housing was only partially protective. Fewer cases of HWI were identified in the final quarter of the year, compared with other periods, and prevalence is not apparently increasing. Signs of respiratory tract disease were most common, followed by vomiting. Infection was diagnosed incidentally in > 25% of cats; conversely, 10% of infected cats died suddenly without other clinical signs. Serologic tests were most useful for diagnosis, followed by radiography and echocardiography. Eosinophilia supported the diagnosis. Overall median survival time was 1.5 years but exceeded 4 years in cats surviving beyond the day of diagnosis.Conclusions and Clinical Relevance—Sex does not appear to be a risk factor for HWI in cats, and indoor housing provides only incomplete protection. Signs of respiratory tract disease (dyspnea and cough) are the strongest indicators of HWI in cats, and some radiographic evidence of infection is detected in most cases. Antibody screening for HWI in cats is efficacious, and antigen testing and echocardiography are most useful for making a definitive antemortem diagnosis. (J Am Vet Med Assoc2000;217: 355–358)
Pulmonary function and adrenal gland suppression with incremental doses of aerosolized beclomethasone dipropionate in horses with recurrent airway obstruction
Authors: Rush Bonnie R. , Raub Elizabeth S. , Thomsen Molly M. , Davis Elizabeth G. , Matson Charles J. , Hakala Joyce E. 
Published: December 2005

AbstractObjective—To evaluate clinical response, pulmonary function, and adrenal gland response to incremental doses of beclomethasone dipropionate in horses with recurrent airway obstruction.Design—Crossover trial.Animals—8 horses with recurrent airway obstruction.Procedure—Horses randomly assigned to 4 groups were treated twice daily via aerosol administration of placebo or 500, 1,000, or 1,500 µg of beclomethasone dipropionate in a crossover design with a 10-day minimum washout period. Subjective assessment of airway obstruction, serum cortisol concentration, and maximum change in pleural pressure during tidal breathing (ΔPplmax) were determined daily prior to morning drug administration, and ΔPplmax was reevaluated 15 minutes after morning drug administration. Pulmonary resistance and dynamic compliance were determined at baseline and approximately 12 hours after the final treatment.Results—An immediate treatment effect was not identified. Within 24 hours, ΔPplmax and airway obstruction were lower in horses receiving beclomethasone. Onset and magnitude of response was similar among the 3 beclomethasone dose regimens. Pulmonary resistance was improved only after administration of all 3 doses of beclomethasone, whereas dynamic compliance was improved after administration of 1,000 µg and 1,500 µg of beclomethasone. Reduction in serum cortisol concentration occurred with all 3 beclomethasone dose regimens; however, the magnitude of adrenal gland suppression was greater in horses receiving 1,000 or 1,500 µg of beclomethasone.Conclusions and Clinical Relevance—Low-dose (500 µg) beclomethasone administration caused similar improvement in pulmonary function, compared with high-dose beclomethasone (1,000 and 1,500 µg), with the exception of dynamic compliance, and caused less suppression of endogenous cortisol production. (J Am Vet Med Assoc2000;217:359–364)
Coronavirus-associated epizootic catarrhal enteritis in ferrets
Authors: Williams Bruce H. , Kiupel Matti , West Keith H. , Raymond James T. , Grant Christopher K. , Glickman Lawrence T. 
Published: December 2005

Abstract

Objective—To characterize clinical signs and lesions
and identify the etiologic agent associated with epizootic
catarrhal enteritis in domestic ferrets.

Design—Cross-sectional study.

Animals—119 ferrets with epizootic diarrhea of presumed
viral cause and 5 control ferrets.

Procedure—Clinical records and biopsy or necropsy
specimens of ferrets with presumed epizootic
catarrhal enteritis were reviewed. Immunohistochemical
staining for coronavirus antigen was performed
on paraffin-embedded tissues from approximately
10% of affected ferrets to identify viral antigen
and determine its distribution. Transmission electron
microscopy was performed on fecal samples and sections
of jejunum. Virus isolation studies as well as
immunofluorescent tests for other similar viruses
were performed.

Results—Characteristic microscopic lesions consistent
with intestinal coronavirus infection (vacuolar
degeneration and necrosis of villus enterocytes; villus
atrophy, fusion, and blunting; and lymphocytic enteritis)
were consistently detected in affected ferrets.
Coronavirus particles were identified in feces and jejunal
enterocytes by use of transmission electron
microscopy. Immunohistochemical staining of jejunal
sections revealed coronavirus antigens. Antigen staining
was not detected in healthy ferrets or ferrets with
other gastrointestinal tract diseases. Virus isolation
was unsuccessful, and other similar viruses were not
detected.

Conclusions and Clinical Relevance—Results
strongly implicate a coronavirus as the causative
agent of epizootic catarrhal enteritis in ferrets.
Diagnosis may be made on the basis of a combination
of historical, clinical, and microscopic findings. (J Am
Vet Med Assoc 2000;217:526–530)
Effect of split nursing on variation in pig growth from birth to weaning
Authors: Donovan Tara S. , Dritz Steve S. 
Published: December 2005

Abstract

Objective—To determine the effect of split nursing
(ie, removal of the larger pigs in a litter from the dam
for a short period within 24 hours after birth to allow
the smaller pigs in the litter uninhibited access to the
dam) on variation in growth from birth to weaning
among pigs.

Design—Clinical trial.

Animals—1,193 pigs in 118 litters.

Procedure—Litters were randomly assigned to 1 of 3
treatment groups: control group (pigs were not split
nursed), group 1 (heaviest 50% of pigs in the litter
were removed from the sow for 2 hours), or group 2
(heaviest 50% of pigs were removed from the sow
for 2 hours and, after the heaviest pigs were returned
to the sow, the lightest 50% of pigs were removed
for 2 hours). Birth weights and weaning weights were
measured.

Results—Significant differences in average daily gain
(ADG), weaning weight, or serum IgG concentration
among groups were not detected. However, significant
linear improvements in the SD and coefficient of
variation of the ADG were detected, but only for litters
with ≥ 9 pigs born alive. Percentages of pigs from
split-nursed litters that weighed < 3.6 kg (8 lb) at
weaning (1.3 and 1.6% for groups 1 and 2, respectively)
were lower than percentage of control pigs that
did (3%).

Conclusion and Clinical Relevance—Results suggest
that split nursing will decrease variation in ADG
of pigs from birth to weaning but only for pigs from litters
with ≥ 9 pigs born alive. (J Am Vet Med Assoc
2000;217:79–81)
Treatment of dogs infected with Hepatozoon americanum: 53 cases (1989–1998)
Authors: Macintire Douglass K. , Vincent-Johnson Nancy A. , Kane Curtis W. , Lindsay David S. , Blagburn Byron L. , Dillon Allen R. 
Published: December 2005

AbstractObjective—To determine clinical and pathologic findings before and after short-term (group 1) and longterm (group 2) treatment in dogs with Hepatozoon americanuminfection.Design—Retrospective study.Animals—53 dogs withH americanuminfection.Procedure—Medical records of dogs that were treated for hepatozoonosis diagnosed on the basis of meront or merozoite stages in skeletal muscle were reviewed.Results—Circulating gametocytes ofH americanumwere identified in 12 of 53 dogs. Dogs were treated with various drugs, including toltrazuril, trimethoprimsulfadiazine, clindamycin, pyrimethamine, and decoquinate. Mean WBC counts prior to treatment were 85,700 and 75,200 cells/µl in groups 1 and 2, respectively, and 1 month after initiation of treatment were 12,600 and 14,600 cells/µl, respectively. Initial response to treatment was excellent in all dogs. Twenty-three of 26 dogs in group 1 relapsed at least once and died within 2 years; mean (± SD) survival time was 12.6 ± 2.2 months. Twenty-two of 27 group-2 dogs survived; 11 dogs had no clinical signs and were still receiving decoquinate (mean duration of treatment, 21 months), 11 dogs had no clinical signs after treatment for 14 months (range, 3 to 33 months; mean survival time, 39 months [range, 26 to 53 months]), 2 dogs were lost to follow-up, and 3 dogs were euthanatized because of severe disease.Conclusions and Clinical Relevance—Although no treatment effectively eliminated the tissue stages ofH americanum, treatment with trimethoprim-sulfadiazine, clindamycin, and pyrimethamine followed by long-term administration of decoquinate resulted in extended survival times and excellent quality of life. (J Am Vet Med Assoc2001;218:77–82)
Findings from aCGH in patients with congenital diaphragmatic hernia (CDH): A possible locus for Fryns syndrome
Authors: Kantarci S. , Casavant D. , Prada C. , Russell M. , Byrne J. , Haug L. Wilkins , Jennings R. , Manning S. , Boyd T.K. , Fryns J.P. , Holmes L.B. , Donahoe P.K. , Lee C. , Kimonis V. , Pober B.R. 
Published: December 2005

AbstractCongenital diaphragmatic hernia (CDH) is a common and often devastating birth defect that can occur in isolation or as part of a malformation complex. Considerable progress is being made in the identification of genetic causes of CDH. We applied array‐based comparative genomic hybridization (aCGH) of ∼1Mb resolution to 29 CDH patients with prior normal karyotypes who had been recruited into our multi‐site study. One patient, clinically diagnosed with Fryns syndrome, demonstrated a de novo 5Mb deletion at chromosome region 1q41–q42.12 that was confirmed by FISH. Given prior reports of CDH in association with cytogenetic abnormalities in this region, we propose that this represents a locus for Fryns syndrome, a Fryns syndrome phenocopy, or CDH. © 2005 Wiley‐Liss, Inc.
A 46,X,inv(Y) young woman with gonadal dysgenesis and gonadoblastoma: Cytogenetics, molecular, and methylation studies
Authors: Gimelli Giorgio , Giorda Roberto , Beri Silvana , Gimelli Stefania , Zuffardi Orsetta 
Published: December 2005

AbstractCytogenetic analysis of a young woman with gonadal dysgenesis and bilateral gonadoblastoma shared a male karyotype with a rearranged Y chromosome, interpreted as a pericentric inversion. The breakpoints, defined by fluorescent in situ hybridization (FISH), were located on the very distal short arm on band Yp11.31 and in the middle of the Yq12 long arm heterochromatic region. FISH analysis documented that the short arm breakpoint was 93 Kb distal to SRY and disrupted the CD99 gene, which was transposed to the distal portion of Yq12. The proposita's phenotype was similar to that of XY individuals with gonadal dysgenesis but without signs of Ullrich—Turner syndrome. There were no mutations in the SRY gene. Cytogenetic analysis in the proposita's father showed mosaicism of a normal Y chromosome and several different rearrangements, such as deletion of a heterochromatin portion at band Yq12.2, a fragile site at the same band, structural rearrangements between the Y‐chromosome and other autosomes, Y‐chromosome aneuploidies, and “Premature Centromere Division” (PCD) anomaly. The proposita's inverted Y chromosome appears to have originated from paternal Y chromosome instability. The patient's female phenotype could be due to SRY CpG methylation‐mediated positional effects (PEV). © 2005 Wiley‐Liss, Inc.
Overrepresentation of small supernumerary marker chromosomes (sSMC) from chromosome 6 origin in cases with multiple sSMC
Authors: Liehr Thomas , Starke Heike , Senger Gabriele , Melotte Cindy , Weise Anja , Vermeesch Joris Robert 
Published: December 2005

AbstractSmall supernumerary marker chromosomes (sSMC) in human are defined as additional centric derivatives smaller than chromosome 20. In the majority of the cases only one sSMC is present, leading to a more or less stable karyotype of 47,XX,+mar or 47,XY,+mar. In ∼1.4% of sSMC cases two or up to seven markers of different chromosomal origin are reported. According to the literature a sSMC(6) was present in 33% of the patients with multiple sSMC while sSMC(6) are observed in <1% of cases with a single sSMC. Currently there is no explanation for this striking observation. Here we report on one more unique case with two sSMC, one derived from #5 and the other from #6. Using microdissection/reverse painting, subcentromere‐specific multicolor FISH (subcenM‐FISH) and multicolor banding (MCB), they could be described as min or r(6)(::p11.1 → q11.1::) and r(5)(::p11.1∼12 → q10::q10 → p11.1∼12::), respectively. Reversed array CGH using the DNA of the microdissected sSMC as probe confirmed the FISH results and enabled the rapid mapping of the breakpoints. © 2005 Wiley‐Liss, Inc.
Characterization of phenol–urea–formaldehyde resin by inline FTIR spectroscopy
Authors: Poljanšek Ida , Šebenik Urška , Krajnc Matjaž 
Published: December 2005

AbstractPhenol–urea–formaldehyde (PUF) resins were synthesized by a two‐step polymerization process. The first step was the synthesis of 2,4,6‐trimethylolphenol (TMeP) from phenol and formaldehyde, under alkaline conditions. In the second step PUF resins were synthesized by the reaction of TMeP with urea, under acidic and alkaline conditions. The influence of temperature on the synthesis of TMeP was investigated. The molar ratio between TMeP and urea was varied to study the composition effect on the second step of the PUF synthesis and final product properties. Synthesis of TMeP and PUF resins were monitored by inline FTIR‐ATR system. Analytical methods, such as differential scanning calorimetry, nuclear magnetic resonance, thermogravimetric analysis, and infrared spectroscopy were used for characterization of TMeP and PUF resins. Obtained PUF resins were cured and tested on flexural strength. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci, 2006
Effect of organoclay on the thermal stability, mechanical strength, and surface wettability of injection‐molded ABS–clay nanocomposite materials prepared by melt intercalation
Authors: Yeh Jui‐Ming , Chen Chi‐Lun , Huang Chao‐Chen , Chang Fang‐Chia , Chen Shia‐Chung , Su Pao‐Lin , Kuo Chih‐Che , Hsu Jui‐Ting , Chen Boyang , Yu Yuan‐Hsiang 
Published: December 2005

AbstractIn this article, a series of polymer–clay nanocomposite (PCN) materials consisted of commercial thermoplastic ABS matrix and dispersing inorganic organoclay platelets were successfully prepared by melt intercalation through the twin‐roller mixer. The as‐prepared materials in the form of pellet were then shaped by injection‐molding machine and the as‐molded specimens were subsequently examined by chemical characterizations, through Fourier transformation infrared (FTIR) spectroscopy, powder X‐ray diffraction (XRD), and transmission electron microscopy (TEM). Effect of the organoclay on thermal stability, mechanical strength, and surface wettability of PCN materials, in both the form of standard dumbbell shape and pellet, was studied using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), tensile test, hardness test, and contact‐angle measurements, respectively. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 99; 1576–1582, 2006