bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heat transfer and thermal–hydraulic evaluations of cross-circular grooved rectangular flow ducts depending on rectangular baffle design parameters
Authors: Karabulut Koray 
Published: March 2024

AbstractThe cross-grooved rectangular flow ducts are largely used for plate heat exchangers. In this work, so as to better the heat transfer in cross-grooved rectangular ducts with circular grooves, rectangular baffles were located in the flow duct, and the influences of the rectangular baffle angles and heights on the features of heat transfer were numerically performed in detail. Equations of Navier–Stokes and energy were resolved by employing a program of Ansys-Fluent with k–ε turbulence model as steady and three-dimensional. Air employed as working fluid has a temperature of inlet 293 K while the circular groove’s wall temperature is 373 K. Rectangular baffles have various angles of 30°, 60°, and 90°, and heights of 0.25 H, 0.5 H, and 0.75 H. The mean Nusselt number (Num), temperature, turbulence kinetic energy (TKE), pressure, and PEC (Performance Evaluation Criterion) number of the flow duct with rectangular baffles were evaluated by comparing it with the cross-circular grooved channel non-baffle. Besides, the contours of velocity, turbulence kinetic energy, temperature, and velocity vector were exhibited for the cross-circular grooved rectangular channels with different baffle angles and height arrangements. Results were matched with experimental and numerical outcomes of the study found in the literature, and it was observed that they were fairly coherent. For Re = 6000, the number of Num increases by 180.48% in the duct with a 90° angle and 0.75 H baffle height compared to the duct non-baffle, and for 30° baffle angle, the PEC value at 0.25 H baffle height is 66.88% higher than that in the 0.5 H.
Graphical Abstract
Compared to the temperature contour distribution in the non-baffle state, the temperature gradient increases due to the turbulence intensity created by the inserting of baffles to the circular grooved ducts. When the baffle height is increased to 0.75 H, the increase in fluid temperatures toward the end of the ducts is the clearest evidence of this situation. Thus, while cooling increases in circular grooves, the temperature gradient in the duct above the circular grooved section gets better, especially in the case of 0.75 H height and 90° baffle angle. Temperature distribution contours of the ducts for non-baffle and with baffle of 90° angle and 0.75 H height for Re = 6000.
Introductory quantum information science coursework at US institutions: content coverage
Authors: Meyer Josephine C. , Passante Gina , Pollock Steven J. , Wilcox Bethany R. 
Published: March 2024

AbstractDespite rapid growth of quantum information science (QIS) workforce development initiatives, perceived lack of agreement among faculty on core content has made prior research-based curriculum and assessment development initiatives difficult to scale. To identify areas of consensus on content coverage, we report findings from a survey of N=63 instructors teaching introductory QIS courses at US institutions of higher learning. We identify a subset of content items common across a large fraction (≥ 80%) of introductory QIS courses that are potentially amenable to research-based curriculum development, with an emphasis on foundational skills in mathematics, physics, and engineering. As a further guide for curriculum development, we also examine differences in content coverage by level (undergraduate/graduate) and discipline. Finally, we briefly discuss the implications of our findings for the development of a research-based QIS assessment at the postsecondary level.
Prevalence of Systemic Hypertension and the Effects of Cerebral Revascularization in Patients With Moyamoya Disease
Authors: Lee Hubert , Ahmed Uzair , Bell‐Stephens Teresa , Steinberg Gary K. 
Published: March 2024

Background

Hypertension is often codiagnosed in patients with moyamoya disease (MMD), a progressive intracranial steno‐occlusive vasculopathy; this has principally been attributed to renal artery stenosis (up to 10%). Susceptibility MMD genes, including ring finger protein 213/mysterin and
GUCY1A3
, have also been linked to extracranial vascular disease and increased systolic blood pressure. We aimed to define the prevalence of systemic hypertension in MMD patients and characterize its evolution after cerebral revascularization.

Methods
Patients with MMD treated with extracranial‐intracranial bypass from 2014 to 2018 were retrospectively enrolled. Blood pressure measurements and antihypertensive agent use were recorded pre‐ and postoperatively. Hypertension was defined according to the 2020 International Society of Hypertension Guidelines (adults) and 2017 American Academy of Pediatrics Guidelines (children). Multivariate logistic regression was performed for clinical and radiographic predictors of hypertension.

Results
A total of 242 adult and 51 pediatric patients underwent revascularization. Preoperatively, 146 adult and 20 pediatric patients met the diagnostic criteria for hypertension resulting in prevalences of 60.3% and 39.2% respectively. In adults, this was significantly associated with age (odds ratio [OR] 1.05 [95% CI, 1.02–1.09]), body mass index (OR, 1.08 [95% CI, 1.03–1.13]), hyperlipidemia (OR, 2.57 [95% CI, 1.09–6.04]), kidney disease (OR, 18.98 [95% CI, 1.80–200.47]), and symptomatic presentation (OR, 8.88 [95% CI, 1.16–68.06]). After a mean follow‐up of 34.3±18.1 months in adults (33.8±14.9 months – children), patients with hypertension decreased by 15.3% (1.9% – pediatrics) and 31.8% (17.7% – children) experienced improvement in hypertensive status with normalization of blood pressure or reduced need for antihypertensive agents. Posterior circulation involvement was a negative predictor for response of hypertensive status to revascularization (OR, 0.10 [95% CI, 0.01–0.79]).

Conclusion
Hypertension is prevalent among adult and pediatric patients with MMD with contributions from known vascular risk factors. Its association with symptomatic presentation and observed improvement following revascularization suggests blood pressure changes, in part, are a compensatory physiological response to increased intracranial vascular resistance.
“When the Cruiser Lights Come On”: Using the Science of
Bias & Culture to Combat Racial Disparities in Policing
Authors: Hetey Rebecca C. , Hamedani MarYam G. , Markus Hazel Rose , Eberhardt Jennifer L. 
Published: March 2024

Abstract
In this essay, we highlight the interplay between individuals' psychological processes and sociocultural systems in producing and maintaining racial bias. We use a conceptual tool we call the culture cycle to map these dynamics, and illustrate them with research and in-depth examples from our work reducing racial disparities in routine policing in Oakland, California. We feature the most common police encounter – the vehicle stop – and highlight evidence-based interventions we developed both to reduce the frequency of vehicle stops and mitigate racial disparities in stops. Throughout, we draw on our expertise in the social psychology of bias, culture, and inequality, as well as our experiences building research-driven partnerships with public- and private-sector leaders, to inform organizational and societal change.
Disrupting the Effects of Implicit Bias: The Case of Discretion
& Policing
Authors: Glaser Jack 
Published: March 2024

Abstract
Police departments tend to address operational challenges with training approaches, and implicit bias in policing is no exception. However, psychological scientists have found that implicit biases are very difficult to reduce in any lasting, meaningful way. Because they are difficult to change, and nearly impossible for the decision-maker to recognize, training to raise awareness or teach corrective strategies is unlikely to succeed. Recent empirical assessments of implicit bias trainings have shown, at best, no effect on racial disparities in officers' actions in the field. In the absence of effective training, a promising near-term approach for reducing racial disparities in policing is to reduce the frequency of actions most vulnerable to the influence of bias. Specifically, actions that allow relatively high discretion are most likely to be subject to bias-driven errors. Several cases across different policing domains reveal that when discretion is constrained in stop-and-search decisions, the impact of racial bias on searches markedly declines.
Little Things Matter a Lot: The Significance of Implicit Bias,
Practically & Legally
Authors: Kang Jerry 
Published: March 2024

Abstract
Skeptics point out that measures of implicit bias can only weakly predict discrimination. And it is true that under current technologies, the degree of correlation between implicit bias (for example, as measured by the Implicit Association Test) and discriminatory judgment and behavior is small to moderate. In this essay, I argue that these little effects nevertheless matter a lot, in two different senses. First, in terms of practical significance, small burdens can accumulate over time to produce a large impact in a person's life. When these impacts are integrated not only over time but double integrated over large populations, these little things become even more practically significant. Second, in terms of legal significance, an upgraded model of discrimination that incorporates implicit bias has started to reshape antidiscrimination law. This transformation reflects a commitment to “behavioral realism”: a belief that the law should reflect more accurate models of human thinking and behavior.
National Minorities in the Odesa Oblast – Applying the European Model to Ensure Peaceful Coexistence
Authors: Carp Radu 
Published: March 2024

Abstract
The article deals with the situation of national minorities living in the Odesa oblast and in the town of Odesa with the main focus before the Russian war against Ukraine started on 24 of February 2022 but using also the relevant events happened afterwards. It explains what are the historical reasons that made Odesa a region so diverse from the national identity perspective, with a lot of national minorities living here from centuries. Although there are a significant number of studies on the issue of the national minorities in this region, none of them captured, so far, the complex relationship of Ukraine with the kin-states – Romania, Bulgaria and in some extent Turkey. The number of idp s in Ukraine was already high before the war started, with an important impact on the relationship of the Ukrainian majority with the national minorities and it will certainly be much higher after the war. The article takes into account this situation particularly for the Odesa oblast. The article examines how the institutions and the religious actors have influenced this relationship but how the war will shape it remains an open question. The article offers a perspective on the 2017 Ukrainian law in education, how it was applied until 24 of February 2022 and also on the 2022 Law on minorities, in order to find an answer to the question why a new framework for the national minorities in Ukraine after the end of the war is very important.
The Impact of Minority Veto in Consociational Democracies
Authors: Beka Rinor , Qirezi Arben 
Published: March 2024

Abstract
Developing governance models that are suitable for the effective management of ethnically divided societies arising from conflicts presents a significant challenge for both scholars and peace mediators. The consociational model, founded on power-sharing principles, has emerged as a means of guiding groups which were previously in conflict towards creating institutional frameworks that can help manage divisions and promote peaceful coexistence. In situations where mutual trust is lacking and deep-seated ethnic, religious, or linguistic divisions persist, it is unrealistic to anticipate that minority groups would willingly grant unrestricted decision-making authority to the majority. Consequently, the notion of constraining the majority’s decision-making powers on specific matters, unless it has the consent of minority groups through the implementation of veto rights, has become a fundamental principle for negotiating post-conflict institutional arrangements. This article aims to investigate the practical ramifications of veto rights within consociational systems, focusing on their incorporation into Kosovo’s legal framework post-2008 and their actual implementation in the years that followed. The article seeks to shed light on how veto rights contribute to consensus-based decision-making, the potential for disruption when exploited by irresponsible political leaders, and the possibilities of revisiting these arrangements to address any shortcomings.
Bahcc1 is critical for the aberrant epigenetic program in a mouse model of MLL-ENL–mediated leukemia
Authors: Nakamura Akihide , Masuya Masahiro , Shinmei Makoto , Tawara Isao , Nosaka Tetsuya , Ono Ryoichi 
Published: March 2024

Abstract
In leukemogenesis, genotoxic stress in hematopoietic stem and progenitor cells (HSPCs) drives individual context-dependent programs of malignant transformation. In light of the various differentiation stages of HSPCs based on a recently revised definition using CD150/CD48, our analyses showed that a subpopulation of long-term repopulating HSCs was most susceptible to MLL-ENL–mediated transformation. An analysis of the molecular mechanism identified Bromo-adjacent homology domain and coiled-coil containing 1 (Bahcc1), which encodes a reader molecule of trimethylated histone H3 lysine 27 (H3K27me3), as a candidate gene involved in distinct susceptibility to leukemic transformation. Interestingly, Bahcc1 was previously reported to be highly expressed in acute myeloid leukemia (AML) with an unfavorable prognosis, including some cases of MLL-rearranged AML. We found that MLL-ENL upregulated Bahcc1 through binding to its promoter, and that Bahcc1 was involved in MLL-ENL–mediated immortalization at least partly through repression of H3K27me3-marked Cdkn1c. Analyses using bone marrow transplantation in mice showed that depletion of Bahcc1 suppressed the leukemogenic activity of MLL-ENL. In a public database, high BAHCC1 expression was found to be associated with a poor prognosis in pediatric AML, in which BAHCC1 expression was significantly lower in MLL-AF9-AML than in other MLL-fusion-AML. These findings shed light on the distinct immortalization potential of HSPCs and suggest a novel MLL-fusion-Bahcc1 axis, which may lead to development of molecular targeted therapy against MLL-fusion–mediated leukemia.
Prevalence, country-specific prescribing patterns and determinants of benzodiazepine use in community-residing older adults in 7 European countries
Authors: Lukačišinová Anna , Reissigová Jindra , Ortner-Hadžiabdić Maja , Brkic Jovana , Okuyan Betul , Volmer Daisy , Tadić Ivana , Modamio Pilar , Mariño Eduardo L. , Tachkov Konstantine , Liperotti Rosa , Onder Graziano , Finne-Soveri Harriet , van Hout Hein , Howard Elizabeth P. , Fialová Daniela 
Published: March 2024

Abstract
Background
The use of benzodiazepines (BZDs) in older population is often accompanied by drug-related complications. Inappropriate BZD use significantly alters older adults’ clinical and functional status. This study compares the prevalence, prescribing patterns and factors associated with BZD use in community-dwelling older patients in 7 European countries.

Methods
International, cross-sectional study was conducted in community-dwelling older adults (65 +) in the Czech Republic, Serbia, Estonia, Bulgaria, Croatia, Turkey, and Spain between Feb2019 and Mar2020. Structured and standardized questionnaire based on interRAI assessment scales was applied. Logistic regression was used to evaluate factors associated with BZD use.

Results
Out of 2,865 older patients (mean age 73.2 years ± 6.8, 61.2% women) 14.9% were BZD users. The highest prevalence of BZD use was identified in Croatia (35.5%), Spain (33.5%) and Serbia (31.3%). The most frequently prescribed BZDs were diazepam (27.9% of 426 BZD users), alprazolam (23.7%), bromazepam (22.8%) and lorazepam (16.7%). Independent factors associated with BZD use were female gender (OR 1.58, 95%CI 1.19–2.10), hyperpolypharmacy (OR 1.97, 95%CI 1.22–3.16), anxiety (OR 4.26, 95%CI 2.86–6.38), sleeping problems (OR 4.47, 95%CI 3.38–5.92), depression (OR 1.95, 95%CI 1.29–2.95), repetitive anxious complaints (OR 1.77, 95%CI 1.29–2.42), problems with syncope (OR 1.78, 95%CI 1.03–3.06), and loss of appetite (OR 0.60, 95%CI 0.38–0.94). In comparison to Croatia, residing in other countries was associated with lower odds of BZD use (ORs varied from 0.49 (95%CI 0.32–0.75) in Spain to 0.01 (95%CI 0.00–0.03) in Turkey), excluding Serbia (OR 1.11, 95%CI 0.79–1.56).

Conclusions
Despite well-known negative effects, BZDs are still frequently prescribed in older outpatient population in European countries. Principles of safer geriatric prescribing and effective deprescribing strategies should be individually applied in older BZD users.
The collaborative framework for the management of tuberculosis and type 2 diabetes syndemic in low- and middle-income countries: a rapid review
Authors: Milice Denise Michela , Macicame Ivalda , L.Peñalvo José 
Published: March 2024

Abstract
Introduction
Given the absence of international guidelines on the joint management and control of tuberculosis (TB) and type 2 diabetes mellitus (T2D), the World Health Organization (WHO) and the International Union Against Tuberculosis and Lung Disease (The Union) launched in 2011 a policy framework to address the growing syndemic burden of TB-T2D. This review aimed at mapping the available evidence on the implementation of the Union-WHO Framework, explicitly, or bi-directional TB-T2D health programs as an initiative for co-management in patients in low- and middle-income countries (LMIC).

Methods
A rapid review was performed based on a systematic search in PubMed and Web of Science electronic databases for peer-reviewed articles on The Union-WHO Framework and bi-directional interventions of TB and T2D in LMIC. The search was restricted to English language articles and from 01/08/2011 to 20/05/2022.

Results
A total of 24 articles from 16 LMIC met the inclusion criteria. Four described the implementation of The Union-WHO Framework and 20 on the bi-directional interventions of TB and T2D. Bi-directional activities were found valuable, feasible and effective following the Union-WHO recommendations. Limited knowledge and awareness on TB-T2D comorbidity was identified as one of the barriers to ensure a functional and effective integration of services.

Conclusions
This review revealed that it is valuable, feasible and effective to implement bi-directional TB and T2D activities (screening and management) according to the Union-WHO Framework recommendations, especially in countries that face TB-T2D syndemic. Additionally, it was apparent that gaps still exist in research aimed at providing evidence of costs to implement collaborative activities. There is need for TB and T2D services integration that should be done through the well-stablished TB programme. This integration of two vertical programmes, could ensure patient-centeredness, continuum of care and ultimately contribute for health systems strengthening.
Metabolic profiling of milk thistle different organs using UPLC-TQD-MS/MS coupled to multivariate analysis in relation to their selective antiviral potential
Authors: El-Banna Alaa A. , Ibrahim Reham S. 
Published: March 2024

Abstract
Introduction
Silybum marianum commonly known as milk thistle is one of the most imperative medicinal plants due to its remarkable pharmacological activities. Lately, the antiviral activities of S. marianum extract have been studied and it showed effectiveness against many viruses.

Objective
Although most previous studies were concerned mainly with silymarin content of the fruit, the present study provides comprehensive comparative evaluation of S. marianum different organs’ chemical profiles using UPLC-MS/MS coupled to chemometrics to unravel potentially selective antiviral compounds against human coronavirus (HCoV-229E).

Methodology
UPLC-ESI-TQD-MS/MS analysis was utilized to establish metabolic fingerprints for S. marianum organs namely fruits, roots, stems and seeds. Multivariate analysis, using OPLS-DA and HCA-heat map was applied to explore the main discriminatory phytoconstituents between organs. Selective virucidal activity of organs extracts against coronavirus (HCoV-229E) was evaluated for the first time using cytopathic effect (CPE) inhibition assay. Correlation coefficient analysis was implemented for detection of potential constituents having virucidal activity.

Results
UPLC-MS/MS analysis resulted in 87 identified metabolites belonging to different classes. OPLS-DA revealed in-between class discrimination between milk thistle organs proving their significantly different metabolic profiles. The results of CPE assay showed that all tested organ samples exhibited dose dependent inhibitory activity in nanomolar range. Correlation analysis disclosed that caffeic acid-O-hexoside, gadoleic and linolenic acids were the most potentially selective antiviral phytoconstituents.

Conclusion
This study valorizes the importance of different S. marianum organs as wealthy sources of selective and effective antiviral candidates. This approach can be extended to unravel potentially active constituents from complex plant matrices.
Development and validation of the missed intensive nursing care scale
Authors: Yang Li , Zhou Wen , Gao Yan , Wu Taiqin , Zhang Huan , Gan Xiuni 
Published: March 2024

Abstract
Background
Missed nursing care is a pervasive issue in hospitals, nursing homes, and communities, posing a significant threat to patient safety and the quality of nursing care. It has adverse effects on patient satisfaction and the motivation of nursing staff. Understanding the causes and nature of these care omissions in clinical settings is essential for implementing effective interventions. This study aims to develop and validate a tool for assessing missed nursing care in adult intensive care units.

Methods
Semi-structured interviews, expert consultations conducted via the Delphi method and item analysis were used to develop the initial scale. Our analysis involved data collected from 400 nurses and employed correlation coefficient analysis, critical ratio assessment, Cronbach’s α coefficient evaluation, discrete trend analysis, and factor analysis, which were grounded in both classical test theory and item response theory, allowing us to scrutinize and refine the items in the scale. To validate the scale, we conveniently sampled 550 nurses and assessed structural validity, internal reliability, split-half reliability, and test-retest reliability to ensure the scale’s robustness and accuracy.

Results
The Missed Intensive Nursing Care Scale (MINCS) comprises three distinct components. Part A serves to collect general information about the participants. In Part B, the missed care elements are categorized into five domains, following the framework of Maslow’s hierarchy of needs theory: physiology, safety, belongingness, esteem, and cognition. Part C is dedicated to detailing the reasons behind missed care, which encompass labor resources, material resources, communication factors, and managerial factors. Remarkably, the Cronbach’s α coefficient for the MINCS stands at an impressive 0.951, with S-CVI values of 0.988 and 0.977 in Part B and C, respectively, underscoring the scale’s exceptional reliability and validity. This demonstrates the scale’s effectiveness in measuring missed nursing care while upholding rigorous standards of quality.

Conclusions
The MINCS emerges as a robust and dependable instrument for quantifying instances of missed care within the ICU. Its efficacy makes it a valuable resource for informing the development of strategies aimed at averting and mitigating the adverse effects associated with missed nursing care.