bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of anthelminthic and antiprotozoal activity of myrrh (Commiphora myrrha) methanolic extract
Authors: Albasyouni S. , Al-Quraishy S. , Al-Hoshani N. , Al-Otaibi T. , Al-Shaebi E. M. , Abdel-Gaber R. 
Published: April 2024

Summary
To treat and control parasitic infections, traditional medical remedies using plant products are utilized as antiparasitic agents rather than standard synthetic chemicals due to drug resistance. Myrrh, a resinous exudate of Commiphora myrrha (Burseraceae), is a powerful antioxidant with a variety of medicinal uses. This study aimed to investigate the effect of the myrrh methanolic extract (MyE) of three concentrations (100, 50, and 25 mg/ml) on the sporulation of oocysts and as an anthelminthic effector via in vitro study. Characterization of the plant was done by Fourier-transform infrared spectroscopy (FT-IR). The earthworm, Eisenia fetida, is used as a model worm to evaluate the anthelminthic activity of MyE. Eimeria labbeana-like oocysts are used as a model protozoan parasite in anticoccidial assays. The sporulation and inhibition (%) of E. labbeana-like were assessed by MyE compared to other chemical substances. FT-IR revealed the presence of twelve active compounds. Our results showed that paralysis and death of earthworms at MyE (100 mg/ml) were 7.88 ± 0.37 and 9.24 ± 0.60 min, respectively, which is more potency when compared to mebendazole (reference drug). In all treated worms, microscopic examinations revealed obvious surface architecture abnormality. This study shows that MyE affects oocysts sporulation in a dose-dependent manner. At 24 and 36 hr, a high concentration of MyE (100 mg/ml) inhibits sporulation by 90.95 and 87.17 %. At 36 hr, other concentrations of MyE (50 and 25 mg/ml), as well as amprolium, DettolTM, and phenol inhibits oocyst sporulation by 40.17 %, 29.34 %, 45.09 %, 85.11 %, and 61.58 %, respectively. According to our research, the MyE extract had powerful anthelmintic and anticoccidial properties.
Kualitas Pelayanan Terhadap Tingkat Kepatuhan Pasien Program Fisioterapi Praktik Mandiri di Malang Raya
Authors: Mayu Abdul Rahmat Amin , Rahmanto Safun , Ma’rufa Siti Ainun 
Published: April 2024

Pendahuluan: Kualitas merupakan keseluruhan karakteristik dari produk dan jasa yang meliputi marketing, engineering, manufacture, dan maintenance dimana produk dan jasa tersebut dalam penggunaannya oleh konsumen/pelanggan akan sesuai dengan kebutuhan dan harapan pelanggan. Selain kualitas pelayanan kesehatan, keberhasilan pelayanan fisioterapi juga ditunjang oleh kepatuhan pasien/klien pada program yang diberikan. Kepatuhan merupakan gambaran sikap, sifat, dan perilaku pasien dalam mengikuti program fisioterapi. Penelitian ini bertujuan untuk mengetahui korelasi antara kualitas pelayanan terhadap tingkat kepatuhan pasien program fisioterapi praktik mandiri di Malang Raya.
Metode: Penelitian kuantitatif deskriptif jenis observasional analitik yang bertujuan menganalisis korelasi antara dua variabel dengan pendekatan “cross-sectional”. Subjek penelitian ini adalah pasien yang menjalani Program Fisioterapi di Malang Raya. Teknik sampling menggunakan accidental sampling berdasarkan kriteria inklusi dan ekslusi.
Hasil: Hasil uji korelasi menggunakan Spearman’s rho didapatkan nilai signifikansi atau Sig. (2-tailed) pada variabel kualitas pelayanan dan tingkat kepatuhan sebesar 0,750 dimana nilai p value >0,05.
Simpulan: Tidak ada korelasi antara kualitas pelayanan terhadap tingkat kepatuhan program fisioterapi praktik mandiri di Malang Raya. Praktik fisioterapi mandiri di Malang Raya harus memberikan perhatian khusus pada peningkatan fasilitas hiburan untuk pasien, terutama mereka yang sedang menunggu antrian untuk terapi. Tingkat kepatuhan pasien fisioterapi praktik mandiri di Malang Raya didominasi oleh pasien dengan tingkat kepatuhan sedang, oleh karena itu, sangat penting bagi fisioterapis untuk memberikan perhatian khusus kepada pasien dengan tingkat kepatuhan sedang, termasuk melalui pendidikan kepada keluarga pasien, dengan tujuan untuk meningkatkan tingkat kepatuhan mereka agar mencapai tingkat yang lebih tinggi dan menghindari penurunan ke tingkat kepatuhan rendah.

Kata Kunci: kualitas pelayanan, kepatuhan pasien, fisioterapi
Hubungan Interaksi Sosial dengan Kualitas Hidup Lansia di Kelurahan Korong Gadang Kecamatan Kuranji Kota Padang
Authors: Rahmah Siti Masyithah 
Published: April 2024

Increased life expectancy has resulted in an increase in the number of elderly people. Over time, the various organ systems of the elderly body undergo changes that cause them to have limitations in activities so that they are considered as helpless individuals and slowly withdraw from society. This results in a decrease in social interaction which will affect the quality of life of the elderly. This study aims to determine the relationship between social interaction and the quality of life of the elderly in Korong Gadang Village, Kuranji District, Padang City. This study is an observational analytic study with a cross sectional design. Data were collected by guided interviews using the social interaction questionnaire and the OPQOL-35 quality of life questionnaire with 60 respondents. Respondents had good social interaction (86.7%) and good quality of life (80.0%). The results of bivariate analysis using the Chi-square statistical test showed a p value = 0.043 (p <0.05). The conclusion of this study is that there is a relationship between social interaction and the quality of life of the elderly in Korong Gadang Village, Kuranji District, Padang City.
Keywords : elderly, social interaction, quality of life
Revealing the Motives Behind Executive and Legislative “Interests” in the Discussion Process and Determination of the Budget Regional Revenue and Expenditures (APBD)
Authors: Razak A. , PS Widodo , Kusmana Endang , Ramli  , Tarmizi Tashadi , Supriyanto Eko 
Published: April 2024

Purpose: This interpretive case study delves into the dynamics of executive and legislative interactions in the determination of Regional Revenue and Expenditures (APBD), aiming to understand the underlying motives driving their actions.

Theoretical Reference: Drawing on Siegel and Marconi's theory, which emphasizes the influence of individual perspectives on budget figures, this study employs symbolic interactionism to explore the behavior and motivations of the Executive and Legislative branches in the APBD process.

Method: Qualitative research is conducted, employing a symbolic interactionism approach to analyze the behavior and discourse of the Executive and Legislative branches during APBD discussions.

Results and Conclusion: The study reveals that despite public rhetoric emphasizing performance-oriented budgeting, traditional practices still largely dictate APBD discussions, hindered by a prevailing paternalistic culture and elite commitments. Conflicts between the branches often arise, delaying APBD approval. The findings suggest a phenomenon of Budgetary Mutualism, where both branches engage in strategic maneuvers to secure mutually beneficial gains while maintaining a facade of harmony. However, underlying this facade is a reality of hypocrisy, where public rhetoric masks conflicting interests and power dynamics.

Implications of Research: This research sheds light on the complexities of APBD determination, highlighting the need to address underlying power dynamics and conflicting interests between the Executive and Legislative branches. Understanding these dynamics is crucial for reform efforts aiming to improve budgetary processes and governance.

Originality/Value: By applying symbolic interactionism to analyze APBD dynamics, this study offers a novel perspective on the behavior and motivations of government actors in budgetary processes. The identification of Budgetary Mutualism and the revelation of underlying hypocrisy contribute to a deeper understanding of governance dynamics.
Investigating the Determinants of Macroeconomic Factors on Outward FDI of Vietnam: The Gravity Model Approach
Authors: Quang Phung Thanh 
Published: April 2024

Objective: The main purpose of this paper is to investigate the motivations of Vietnam’s outward FDI.

Theoretical framework: We extend the gravity model proposed by by Tinbergen (1962) and developed by Ryan W. Tang et. al (2022); Correa da Cunha et. al (2022), Hui-Ching Hsieh et. al (2019) to evaluate the influence of macroeconomic factors of Vietnam and the host countries on the volume of Vietnam’s OFDI flow.

Method: This paper intends to analyze the motivations of outward FDI pattern of Vietnam using the gravity theory and panel data of 15 main OFDI host economies during a 2007-2021 period.

Results and discussion: The regression results confirm that the size of the economy, social index, common borderline and level of economic integration have positive influence on OFDI flows of Vietnam. Meanwhile, geographical distance has negative effect on OFDI flows

Implications: As practical policy recommendations, it is suggested to implement measures aimed at enhancing trade relations and to introduce a new strategy regarding the policy for Foreign Direct Investment (FDI) in neighboring regions.

Originality: To the best of author’s knowledge, there has not been any in-depth academic study focusing on the Vietnam’s outward FDI. In addition, robustness checks have been conducted to ensure the validation of empirical findings.
Point of Care Ultrasound for Diagnosis and Management in Heart Failure: A Targeted Literature Review
Authors: Yampolsky Sabina , Kwan Alan , Cheng Susan , Kedan Ilan 
Published: April 2024

Background: Cardiac point of care ultrasound (POCUS) has shown increasing utility as a tool for diagnosing and managing heart failure (HF). Within cardiology, volume assessment leveraging visualization of the inferior (IVC) is a central aspect of care, as IVC size correlates with central venous pressure. This targeted literature review aimed to examine the existing literature assessing the use of POCUS in diagnosis and management of HF patients utilizing POCUS-based IVC measurement either alone or in combination with secondary methods. Methods: A targeted PubMed and Ovid database search up until August 28, 2023 using a keyword search was completed. Studies that did not include IVC assessment with POCUS in HF were excluded. Results: The initial search using both PubMed and Ovid resulted in 370 journal publications. After exclusion criteria were used 15 studies were included in the review. Studies were grouped into three categories: 1) how well POCUS was able to identify HF, 2) whether POCUS-based findings correlated with other measures evaluating HF and was able to predict the effect of diuretic administration, and 3) whether POCUS-based findings served as a good prognostic indicator. The 5 studies that evaluated HF identification with POCUS found that both diagnostic sensitivity and specificity may reach 90%-100% when IVC measurement was coupled with a lung ultrasound assessing the presence of B-lines or effusion. Five studies assessing POCUS findings correlating with other HF measures and diuretic effect found that IVC diameter changed significantly with diuretic administration (p&lt;0.05). All 6 studies assessing POCUS as a predictor of long-term mortality or hospital readmission found measures that achieved statistical significance with p&lt;0.05. Conclusions: Including POCUS as standard-of-care both as a diagnostic tool in the emergency department and a management tool in in-patient and out-patient facilities may improve the treatment of HF.
Case report on spontaneous remission in paroxysmal nocturnal hemoglobinuria: a rare phenomenon
Authors: Hussain Mussawair , Hussain Fayyaz , Qamar Unaiza , Khan Safia , Ali Syed Asif , Ahmed Parvez 
Published: April 2024

Background:
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder characterized by a deficiency of GPI-anchored proteins in blood cells. It is associated with hemolysis, thromboembolic events, and bone marrow failure. Management includes complement inhibitors, anticoagulation, and stem cell transplantation. Spontaneous remission of PNH is rarely reported.

Case Presentation:
A 28-year-old male initially diagnosed with aplastic anemia developed portal vein thrombosis and was subsequently diagnosed with PNH. Due to the unavailability of complement inhibitors, anticoagulation therapy and supportive care were employed. Splenectomy with splenorenal shunt was performed for chronic thrombosis and associated complications. The patient achieved spontaneous remission with normalized blood counts and diminished PNH clone.

Conclusion:
Managing PNH in resource-limited settings presents challenges due to the unavailability of complement inhibitors. Spontaneous remission of PNH is rarely reported and needs further research. A multidisciplinary approach, accessibility to diagnostic tests, and advanced treatments will enhance PNH management in resource-limited settings.
A New Insight Into Toxicity of Database Compounds from Ginger (Zingiber officinale) by Modelling Study
Authors: Frimayanti Neni , Febrina Mira , Yuri Amalia Annisa 
Published: April 2024

Dengue haemorrhagic fever (DHF) is an infectious disease caused by the dengue virus. The dengue virus is transmitted through female mosquitoes, especially Aedes aegypti and Aedes albopictus. Indonesia is a dengue endemic country, and almost all provinces in Indonesia are infected with dengue. However, targeted antiviral drugs against dengue virus (DENV) are not yet available. This study aimed to determine the potential of three compounds isolated from ginger (Zingiber officinale) as dengue NS2B/NS3 inhibitors, and to predict the physicochemical properties (drug-likeness) and potential toxicity of drug candidates. Ginger isolates in the form of [8]-gingerol, [6]-paradol, shogaol were obtained from the Natural Discovery Database (NADI). Toxicity and drug-likeness predictions were performed using ProTox-II and SwissADME, and Molecular Operating Environment (MOE) 2022.0901 was used for the molecular docking process. Results: The results showed that the ginger compound (Zingiber officinale), [8]-Gingerol, [6]-Paradol, and Shogaol, had binding free energy of -7.18, -7.10 and -6.88 kcal/mol, respectively. It is indicated that three compounds had potentiality to inhibit the NS2B/NS3 protein complex with a binding free energy that was almost equivalent to that of the positive control, panduratin A, and similar to that of the positive control, which can be seen in superimposition. In addition, three compounds isolated from ginger met the drug-likeness parameters. Based on the analysis of in silico toxicity studies, the three compounds isolated from ginger showed different levels of toxicity. Therefore, based on the safety level of oral use, the [8]-gingerol compound is safer to develop as a dengue antiviral drug, where the LD50 value of [8]-gingerol is 2.580 mg/kg with a class V toxicity level that is practically nontoxic.
PEMBELAJARAN BERBICARA DENGAN MENGGUNAKAN METODE MUDZAKARAH DI SMK AL-HUDA TURALAK KABUPATEN CIAMIS
Authors: Setiawan Agus Setiawan , Herdiana Herdiana , Juandi Juju 
Published: April 2024

ABSTRAK Tujuan penelitian ini adalah : 1) Ingin mendeskripsikan perencanaan pembelajaran berbicara dengan menggunakan metode mudzakarah di SMK Al-huda Turalak Kabupaten Ciamis. 2) Ingin mendeskripsikan pelaksanaan pembelajaran berbicara dengan menggunakan metode mudzakarah di SMK Al-huda Turalak Kabupaten Ciamis. 3) Ingin mengetahui perubahan kemampuan siswa dalam pembelajaran berbicara setelah menggunakan metode mudzakarah di SMK Al-huda Turalak Kabupaten Ciamis. Metode yang digunakan dalam penelitian ini adalah kuanitataif dengan rancangan deskriptif. Variabel pada penelitian ini terdiri dari satu variabel yaitu pembelajaran berbicara dengan menggunakan metode mudzakarah. Variabel ini mempunyai tiga subvariabel yaitu; 1) perencanaan pembelajaran, 2) pelaksanaan pembelajaran, 3) perubahan kemampuan siswa. Penelitian ini dilakukan di kelas XI SMK Al Huda Turalak. Pengumpulan data penelitian ini menggunakan teknik kajian pustaka, teknik observasi, teknik pembelajaran dan teknik tes. Hasil dari penelitian ini yaitu 1) perencanaan pembelajaran Bahasa Indonesia dengan menggunakan metode mudzakarah di SMK Al-huda Turalak Kabupaten Ciamis, guru melakukan analisis terhadap perencanaan pembelajaran berbicara, terbukti sesuai dengan metode mudzakarah yang digunakan pembelajaran. Pernyataan tersebut diperkuat dengan penilaian observatory terhadap keseluruhan komponen pembelajaran. 2) pelaksanaan dengan metode pembelajaran Mudzakarah yaitu cukup memberikan keyakinan akan keberhasilan guru dan siswa dalam menempuh langkah-langkah pembelajaran membaca pemahaman dalam cerpen yang disajikan dengan penerapan metode mudzakarah.. 3) Perubahan kemampuan siswa dalam pembelajaran berbicara di lingkungan belajar menggunakan metode mudzakarah yaitu kelompok eksperimen yang dilakukan dengan menerapkan metode mudzakarah pada pembelajaran berbicara. Perolehan rata-rata skor prates yaitu 65,33 sedangkan pada postes diperoleh rata-rata skor 84,67. Dengan demikian terdapat perubahan kemampuan siswa yang buktikan dengan selisih skor antara prates dan pascates yaitu 19,34. Kelompok kontrol yang dilakukan dengan menerapkan teknik tanyajawab pada pembelajaran membaca pemahaman dalam cerpen. Perolehan rata-rata skor prates yaitu 60,83 sedangkan pada pascates diperoleh rata-rata skor 81,25. Dengan demikian terdapat perubahan kemampuan siswa yang dibuktikan dengan selisih skor antara prates dan pascates yaitu 20,42.
PENGARUH PENERAPAN ICE BREAKING TERHADAP MOTIVASI BELAJAR SISWA KELAS VII SMPN 1 MALANGBONG
Authors: Rengganis Anggit , Agustini Rina , Hidayat Taufuk 
Published: April 2024

Penelitian ini berjudul “Pengaruh Penerapan Ice Breaking Terhadap Motivasi Belajar Siswa Kelas VII SMPN 1 Malangbong" Penelitian ini bertujuan untuk : 1)Mendeskripsikan penerapan Ice Breaking pada Pembelajaran Bahasa Indonesia kelas VII SMPN 1 Malangbong.2) mendeskripsikan motivasi belajar siswa kelas VI SMPN 1 Malangbong setelah dilakukan penerapan Ice Breaking.3)mendeskripsikan pengaruh penerapan Ice Breaking terhadap motivasi belajar siswa kela VII SMPN 1 Malangbong. Metode yang digunakan dalam Penelitian ini adalah metode kuantitatif. Teknik pengumpulan data yang digunakan adalah teknik angket, observasi, dan dokumentasi Peneliti menggunakan langkah-langkah metode analisis data kuantitatif yaitu 1) Editing (penyuntingan) 2)Koding (pengkodean) 3) Tabulating (tabulasi) Berdasarkan hasil penelitian tersebut bahwa. Analisis data menggunakan korelasi sederhana, teknik regresi, yang terdiri dari regresi linier sederhana. Hasil penelitian ini menemukan bahwa: terdapat hubungan positif antara Ice Breaking dengan Motivasi Belajar siswa kelas VII SMPN 1 Malangbong. Ini berarti bahwa semakin baik penerapan Ice Breaking semakin baik pula Motivasi Belajar siswa. Berdasarkan hasil analisis data Terdapat pengaruh yang positif dan signifikan Ice Breaking terhadap motivasi belajar siswa. Hal tersebut diperoleh berdasarkan hasil uji t tingkat signifikan 0,5 diperoleh thitung = 5,055 sedangkan ttabel = 0,584. Kata Kunci: Ice Breaking,Motivasi Belajar
GAYA BAHASA SATIRE DALAM DALAM CHANNEL YOUTUBE ROCKY GERUNG OFFICIAL (Alternatif Bahan Ajar Pembelajaran Puisi KD 4.17 Kelas X
Authors: Ilham Ilmiawan , Rohayati Nia , Herdiana Herdiana 
Published: April 2024

Penelitian ini berjudul Gaya Bahasa satire dalam channel Youtube Rocky Gerung Official. Penelitian ini dilatarbelakangi dengan permasalahan gaya bahasa satire apa saja yang terdapat pada konten tersebut dan implikasi terhadap pengembangan bahan ajar pada KD.4.17 sehingga pendidik dituntut untuk memilih dan menggunakan bahan ajar yang sesuai dengan keriterianya. Berdasarkan hal tersebut, konten youtube channel Rocky Gerung diharapkan bisa menjadi bahan ajar yang sesuai dengan kriteria bahan ajar dengan mengkaji tentang gaya bahasa satire dalam konten tersebut sebagai alternatif bahan pembelajaran dalam menelan unsur dari konten youtube channe, Rocky Gerung. Penelitian ini bertujuan untuk mendeskripsikan gaya bahasa yang terdapat dalam konten youtube channel Rocky Gerung. Metode penelitian yang digunakan adalah metode deskriptif, karena penulis ingin mendeskripsikan gaya bahasa yang terdapat pada konten youtube channel Rocky Gerung. Objek dalam penelitian ini adalah gaya bahasa dalam konten youtube channel Rocky Gerung. Sumber yang digunakan yaitu channel youtube Rocky Gerung Official, sedangkan penelitian ini yaitu berupa contoh contoh kata satire yang dikomunikasikan oleh Rocky Gerung dalam konen youtub channel Rocky Gerung Official. Teknik penelitian yang digunakan dalam penelitian adlah teknik telaah pustaka, teknik analisis dan teknik dokumentasi. Berdasarkan pembahasan hasil penelitian, dapat disimpulkan gaya bahasa pada konten channel Youtube Rocky Gerung terdapat dua gaya Bahasa satire yaitu 1). Satire Horatian yang memiliki makna sebagai kata sindiran yang digunakan untuk menyindir dengan halus dan tidak menyinggung pihak yang di sindir, 2). Gaya Bahasa satire Juvenalian yang memiliki makna sebagai gaya Bahasa sindiran untuk menyindir dengan keras dan mempermalukan supaya dapat membuat pihak yang di sindir berpikir.Kata Kunci: Rocky Gerung, Gaya Bahasa, Satire, Horatian, Juvenalian.
Assessing the impact of the COVID-19 pandemic on the quality of evidence reported in the leading orthodontic journals
Authors: Abubakar Khadijah Magaji , Tashkandi Nada , Ferguson Donald , Fouad Maha , Allam Eman 
Published: April 2024

Objectives:
The objective of this study was to assess the effect of the COVID-19 pandemic on the quality of research reporting of the most recent orthodontic literature published in three of the highest impact factor orthodontic journals.

Material and Methods:
The American Journals of Orthodontics and Dentofacial Orthopedics (AJODO), European Journal of Orthodontics (EJO), and Angle Orthodontist (AO) were searched for randomized controlled trials (RCTs) published from January 2018 to March 2022. Trials were evaluated using the consolidated standards of reporting trial (CONSORT) checklist. Independent t-test was used to compare pre-COVID and post-COVID RCTs across CONSORT percentages and to compare journals where those trials were published. Multiple linear regressions were used to study the association of different characteristics with the CONSORT percentage scores. P < 0.05 was considered statistically significant.

Results:
A total of 117 RCTs were retrieved from the three journals between January 2018 and March 2022. Thesample was classified as 63 pre-COVID studies (53.8%) and 54 (46.2%) post-COVID studies published in three orthodontics journals (27 in AJODO [23.1%], 45 [38.5%] in AO, and 45 [38.5%] in the EJO). The mean percentage of CONSORT compliance was 84.51% ± 14.34%. There was a statistically significant association of CONSORT scores with journals where the trials were published. Compared to AJODO, AO had a lower CONSORT percentage by an average of 18.81, P < 0.001. Independent t-test was performed to compare RCTs pre/post-COVID across CONSORT percentages. It showed no statistically significant difference as the mean compliance was 84.96 ± 16.01 for the pre-COVID studies and 83.99 ± 12.25 for post-COVID (P = 0.711).

Conclusion:
Overall, CONSORT mean score was 84.51% ± 14.34%. AJODO had the highest CONSORT compliance score while AO had the least compliance score. The quality of reporting of RCTs in orthodontic journals was not affected by the pandemic.