bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple Components of Photodynamic Therapy Can Phosphorylate Akt†
Authors: Bozkulak Ozguncem , Wong Sam , Luna Marian , Ferrario Angela , Rucker Natalie , Gulsoy Murat , Gomer Charles J. 
Published: September 2007

AbstractA growing number of clinically relevant molecular and cellular responses are observed following photodynamic therapy (PDT). PDT‐mediated oxidative stress and PDT‐induced tissue hypoxia can elicit the transcriptional and/or translational expression of genes associated with cellular stress, inflammation, angiogenesis, immuno‐modulation, apoptosis and signal transduction. One of the signaling molecules activated by oxidative stress is Akt/protein kinase B. Phosphorylation of Akt/protein kinase B activates this signaling molecule and induces a survival response in effected cells and tissue. We hypothesized that PDT using Photofrin (PH) as the photosensitizer could also induce increased levels of Akt phosphorylation. Results from our initial set of experiments demonstrated that in vitro and in vivo PDT treatments induced Akt phosphorylation. Interestingly, incubation of mouse and human breast cancer cells with the porphyrin‐based photosensitizer, PH, increased the expression of Akt phosphorylation in the absence of light. Exposure of the corresponding mouse and human‐derived breast cancer tumors growing in mice to 630 nm light in the absence of PH administration also induced Akt phosphorylation. These results demonstrate that individual components of the PDT process, photosensitizer alone and light alone, as well as the complete PDT procedure can activate the Akt signaling pathway.
Development of a Quantitative Bio/Chemiluminescence Spectrometer Determining Quantum Yields: Re‐examination of the Aqueous Luminol Chemiluminescence Standard
Authors: Ando Yoriko , Niwa Kazuki , Yamada Nobuyuki , Irie Tsutomu , Enomoto Toshiteru , Kubota Hidehiro , Ohmiya Yoshihiro , Akiyama Hidefumi 
Published: September 2007

AbstractWe have developed a bio/chemiluminescence spectrometer with a cooled charge‐coupled‐device (CCD) detector to obtain a quantitative luminescence spectrum as the absolute number of all emitted photons at each wavelength. The integrated area of the spectrum divided by the number of reacted substrate molecules gives the quantum yield. Calibration of the absolute sensitivity of the CCD‐spectrometer system was performed by using lasers and a tungsten lamp with calibrated powers as primary light standards, and calibration of the light‐collection efficiency of the spectrometer with several kinds of cells for liquid samples was achieved by introducing a simple reference double‐plate cell. The reference cell is not convenient for final bio/chemiluminescence measurements but is useful for the calibration because it has well‐defined angular dependence of light emission, allowing accurate calculation of the light‐collection efficiency. Using this CCD‐spectrometer system, we re‐examined the quantum yield of aqueous luminol chemiluminescence with H2O2 catalyzed by horseradish peroxidase. The quantum yield was constant for a wide range of luminol concentrations, whereas it changed and had an optimum against H2O2 concentrations. The optimum quantum yield was 1.23(±0.20)%, which is in good agreement with previously reported values.
Space and the State
Authors: Martin James 
Published: September 2007

AbstractSpeculation over the imminent demise of the nation‐state has recently given way to a more nuanced understanding of its ongoing transformation under globalising conditions. Far from disappearing, argue some, the state is subject to a process of ‘rescaling’ whereby its spatial dimensions are being radically reordered. What is emerging to replace post‐war welfare states is a new and more complex layering of the spaces of governance.
A ‘Rave’ Review: Conceptual Interests and Analytical Shifts in Research on Rave Culture
Authors: Anderson Tammy L. , Kavanaugh Philip R. 
Published: September 2007

AbstractRaves have historically referred to grassroots organized, antiestablishment and unlicensed all‐night dance parties, featuring electronically produced dance music, such as techno, house, trance and drum and bass. Since their late‐1980s origins in the UK, raves have gained widespread popularity and transformed dramatically. Consequently, their many cultural traits and behaviors have garnered much sociological interest, which mostly falls into two competing perspectives: cultural studies and public health. In this paper, we review what raves look like today compared to their high point in the 1990s. We then discuss how the cultural studies and public health perspectives define raves and have studied them over time, focusing on the ‘pet’ sociological concepts each has sought to advance. Our analysis of these literatures reveals important differences in rave research by country and over time. We end by discussing the politics associated with the shift in rave research.
Mixed Layer Instabilities and Restratification
Authors: Boccaletti Giulio , Ferrari Raffaele , Fox-Kemper Baylor 
Published: September 2007

Abstract
The restratification of the oceanic surface mixed layer that results from lateral gradients in the surface density field is studied. The lateral gradients are shown to be unstable to ageostrophic baroclinic instabilities and slump from the horizontal to the vertical. These instabilities, which are referred to as mixed layer instabilities (MLIs), differ from instabilities in the ocean interior because of the weak surface stratification. Spatial scales are O(1–10) km, and growth time scales are on the order of a day. Linear stability analysis and fully nonlinear simulations are used to study MLIs and their impact on mixed layer restratification. The main result is that MLIs are a leading-order process in the ML heat budget acting to constantly restratify the surface ocean. Climate and regional ocean models do not resolve the scales associated with MLIs and are likely to underestimate the rate of ML restratification and consequently suffer from a bias in sea surface temperatures and ML depths. In a forthcoming paper, the authors discuss a parameterization scheme to include the effect of MLIs in ocean models.
The Propagation Mechanism of a Vortex on the β Plane
Authors: van Leeuwen Peter Jan 
Published: September 2007

Abstract
The propagation velocity and propagation mechanism for vortices on a β plane are determined for a reduced-gravity model by integrating the momentum equations over the β plane. Isolated vortices, vortices in a background current, and initial vortex propagation from rest are studied. The propagation mechanism for isolated anticyclones as well as cyclones, which has been lacking up to now, is presented. It is shown that, to first order, the vortex moves to generate a Coriolis force on the mass anomaly of the vortex to compensate for the force on the vortex due to the variation of the Coriolis parameter. Only the mass anomaly of the vortex is of importance, because the Coriolis force due to the motion of the bulk of the layer moving with the vortex is almost fully compensated by the Coriolis force on the motion of the exterior flow. Because the mass anomaly of a cyclone is negative the force and acceleration have opposite sign. The role of dipolar structures in steadily moving vortices is discussed, and it is shown that their overall structure is fixed by the steady westward motion of the mass anomaly. Furthermore, it is shown that reduced-gravity vortices are not advected with a background flow. The reason for this behavior is that the background flow changes the ambient vorticity gradient such that the vortex obtains an extra self-propagation term that exactly cancels the advection by the background flow. Last, it is shown that a vortex initially at rest will accelerate equatorward first, after which a westward motion is generated. This result is independent of the sign of the vortex.
Fast Northward Energy Transfer in the Atlantic due to Agulhas Rings
Authors: van Sebille Erik , van Leeuwen Peter Jan 
Published: September 2007

Abstract
The adiabatic transit time of wave energy radiated by an Agulhas ring released in the South Atlantic Ocean to the North Atlantic Ocean is investigated in a two-layer ocean model. Of particular interest is the arrival time of baroclinic energy in the northern part of the Atlantic, because it is related to variations in the meridional overturning circulation. The influence of the Mid-Atlantic Ridge is also studied, because it allows for the conversion from barotropic to baroclinic wave energy and the generation of topographic waves. Barotropic energy from the ring is present in the northern part of the model basin within 10 days. From that time, the barotropic energy keeps rising to attain a maximum 500 days after initiation. This is independent of the presence or absence of a ridge in the model basin. Without a ridge in the model, the travel time of the baroclinic signal is 1300 days. This time is similar to the transit time of the ring from the eastern to the western coast of the model basin. In the presence of the ridge, the baroclinic signal arrives in the northern part of the model basin after approximately 10 days, which is the same time scale as that of the barotropic signal. It is apparent that the ridge can facilitate the energy conversion from barotropic to baroclinic waves and the slow baroclinic adjustment can be bypassed. The meridional overturning circulation, parameterized in two ways as either a purely barotropic or a purely baroclinic phenomenon, also responds after 1300 days. The ring temporarily increases the overturning strength. The presence of the ridge does not alter the time scales.
The Influence of Diapycnal Mixing on Quasi-Steady Overturning States in the Indian Ocean
Authors: Palmer Matthew D. , Garabato Alberto C. Naveira , Stark John D. , Hirschi Joël J-M. , Marotzke Jochem 
Published: September 2007

Abstract
A regional general circulation model (GCM) of the Indian Ocean is used to investigate the influence of prescribed diapycnal diffusivity (Kd) on quasi-steady states of the meridional overturning circulation (MOC). The model has open boundaries at 35°S and 123°E where velocity, temperature, and salinity are prescribed at each time step. The results suggest that quasi-steady overturning states in the Indian Ocean are reached on centennial time scales. The size and structure of the MOC are controlled by the distribution of Kd and the southern boundary conditions. The distribution of Kd required to support an overturning circulation in the model interior of a magnitude equal to that prescribed at the southern boundary is estimated using a 1D advection–diffusion balance in isopycnal layers. Implementing this approach, 70%–90% of the prescribed deep inflow can be supported in quasi-steady state. Thus one is able to address the systematic discrepancy between past estimates of the deep MOC based on hydrographic sections and those based on GCM results. However, the Kd values required to support a substantial MOC in the model are much larger than current observation-based estimates, particularly for the upper 3000 m. The two estimates of the flow field near 32°S used to force the southern boundary imply a highly nonuniform distribution of Kd, as do recent estimates of Kd based on hydrographic observations. This work highlights the need to improve and implement realistic estimates of (nonuniform) Kd in ocean and coupled ocean–atmosphere GCMs when investigating quasi-equilibrium model states.
Ocean and Atmosphere Storm Tracks: The Role of Eddy Vorticity Forcing
Authors: Williams Richard G. , Wilson Chris , Hughes Chris W. 
Published: September 2007

Abstract
Signatures of eddy variability and vorticity forcing are diagnosed in the atmosphere and ocean from weather center reanalysis and altimetric data broadly covering the same period, 1992–2002. In the atmosphere, there are localized regions of eddy variability referred to as storm tracks. At the entrance of the storm track the eddies grow, providing a downgradient heat flux and accelerating the mean flow eastward. At the exit and downstream of the storm track, the eddies decay and instead provide a westward acceleration. In the ocean, there are similar regions of enhanced eddy variability along the extension of midlatitude boundary currents and the Antarctic Circumpolar Current. Within these regions of high eddy kinetic energy, there are more localized signals of high Eady growth rate and downgradient eddy heat fluxes. As in the atmosphere, there are localized regions in the Southern Ocean where ocean eddies provide statistically significant vorticity forcing, which acts to accelerate the mean flow eastward, provide torques to shift the jet, or decelerate the mean flow. These regions of significant eddy vorticity forcing are often associated with gaps in the topography, suggesting that the ocean jets are being locally steered by topography. The eddy forcing may also act to assist in the separation of boundary currents, although the diagnostics of this study suggest that this contribution is relatively small when compared with the advection of planetary vorticity by the time-mean flow.
Group-Level Organizational Citizenship Behavior in the Education System: A Scale Reconstruction and Validation
Authors: Vigoda-Gadot Eran , Beeri Itai , Birman-Shemesh Taly , Somech Anit 
Published: September 2007

Purpose: Most writings on Organizational Citizenship Behavior (OCB) to date have focused on analysis at the individual level and paid less attention to other analytical frameworks at the group level (i.e., team, unit, or organization). This article approaches OCB from the less conventional perspective of group-level activities and uses it to develop and validate a scale of Group-level Organizational Citizenship Behavior (GOCB) in the education system. Data Collection: Data were collected from a survey of 206 Israeli teachers and their principals at 13 schools. Findings: The scores were found to be statistically valid and demonstrated a high degree of reliability. In addition, two intra-factors (GOCB-I [group-level OCB toward individuals] and GOCB-O [group-level OCB toward the organization]) that are quite similar to those suggested in previous OCB literature emerged as key components. Conclusions: The advantages of the group-level scale over other individual-level scales are explored and discussed in detail. The article ends with theoretical and practical implications for future studies that may focus on the “good platoon syndrome” of educational and other administrative systems rather than merely on the “good soldier syndrome.” The authors elaborate on the potential reconstruction of group-level measures of OCB that can enrich studies on organizational climate, culture, and social norms. Finally, the authors argue that their results as well as those suggested in previous research may direct future studies to develop the idea of “organizational citizenship climate” in the educational system and beyond.
Assessing Influence on the Field: An Analysis of Citations to Educational Administration Quarterly, 1979—2003
Authors: Haas Eric , Wilson Glen Yahola , Cobb Casey D. , Hyle Adrienne E. , Jordan Kitty , Kearney Kerri S. 
Published: September 2007

Study Purpose: This article examines the influence of Educational Administration Quarterly (EAQ) on the scholarly literature in education during the 25-year period 1979 to 2003. This article continues part of the first critique of EAQ conducted by Roald Campbell in 1979. Study Methods: Two citation measures are used in this study to assess EAQ influence: (a) citation frequency, the total citations counts to EAQ articles found in the Web of Science database and (b) the impact factor, a ratio of citations to articles published that is calculated as part of the Journal Citation Reports . Study Findings: The findings point to three conclusions: (a) EAQ's substantive, ongoing influence on the scholarly education literature is limited to a small percentage of its published articles, which are cited predominantly by subsequent articles in EAQ; (b) this level of influence, though perhaps not the form, appears to be generally comparable to the level of other scholarly education journals with a solid academic reputation; and (c) EAQ appears to be statistically among the top tier of influential scholarly journals in education, but below the most influential. Overall, EAQ's influence on the scholarly education literature has improved since the first critique published in 1979.
Allocating Quality: Collective Bargaining Agreements and Administrative Discretion Over Teacher Assignment
Authors: Cohen-Vogel Lora , Osborne-Lampkin La'Tara 
Published: September 2007

Background: School leaders argue that to make the improvements in both quality and equity that government mandates demand, they need more flexibility with regard to personnel management—specifically, teacher assignment. According to some, such flexibility is constrained by collective bargaining between teachers unions and school districts. Purpose: To examine how collective bargaining agreements govern the assignment of teachers to schools and classrooms and whether any observed variation among the agreements is due to district demographics and/or performance. Research Methods: Sixty-six collective bargaining agreements between teachers unions and Florida's school districts were collected and analyzed for provisions germane to teacher assignment. The authors looked for contrasts among the contracts by district size, district socioeconomic status, district race, and district Florida Comprehensive Assessment Test performance with data from the Florida Department of Education. Findings: Although staffing rules often favor seniority, contracts also grant administrators more discretion over transfers, reductions, and reassignments than critics have suggested. In addition, contracts are no more likely to restrict administrators' decisions about assignment in large, poor, minority, or low-performing districts than they are in other districts. Implications for Research and Practice: Future research should consider whether teacher assignment looks any different in districts where contracts grant administrators discretion over teacher assignment. If so, what norms have replaced seniority as the primary basis for transfers, reductions, and reassignments, and do these norms hold promise for school improvement and equity? The authors encourage the development and testing of new systems that use teachers' past performance with different types of students to make evidence-based assignments.
Accuracy of Stress Radiography Techniques in Grading Isolated and Combined Posterior Knee Injuries
Authors: Garavaglia Guido , Lubbeke Anne , Dubois-Ferrière Victor , Suva Domizio , Fritschy Daniel , Menetrey Jacques 
Published: September 2007

Background Stress radiography techniques have been shown to be superior to the arthrometer and clinical examination in evaluating the posterior cruciate ligament—deficient knee, but no precise relationship has been established between the extent of the lesion and the laxity measured by stress radiography. Hypothesis It is possible to establish a precise relation between posterior laxity and the anatomical lesions of the posterior cruciate ligament and posterior structures using stress radiography. Study Design Controlled laboratory study. Methods Measurements were performed on 15 fresh-frozen cadaveric knee specimens. A partial posterior cruciate ligament lesion was created by sectioning the anterolateral bundle, followed by a complete section. Then the lateral collateral ligament and the posterolateral corner were transected, and finally the medial collateral ligament and the posteromedial corner were sectioned. Stress radiography was performed first on the intact knee and again after each lesion was created using 4 techniques: Gravity Sag View, PCL-Press, Telos at 80°, and Telos at 30° of flexion. Results Telos 30 and Telos 80 revealed the best overall performance as a diagnostic test in terms of accuracy in discriminating between the different types of lesions. Using the Telos device, we determined the following cut-off points: for a partial lesion, less than 3 mm at 30° and less than 6 mm at 80°; for a complete lesion, between 4 mm and 9 mm at 30° and between 7 mm and 12 mm at 80°; for associated peripheral lesions, more than 9 mm at 30° and more than 12 mm at 80°. Conclusion The Telos 30° and 80° allow us to accurately distinguish between the different types of lesion and permit grading of posterior knee laxity. Clinical Relevance Stress radiography allows characterization of posterior knee injuries and helps to determine treatment strategy.
Extracorporeal Shock Wave Therapy in Treatment of Delayed Bone-Tendon Healing
Authors: Wang Lin , Qin Ling , Lu Hong-Bin , Cheung Wing-Hoi , Yang Hu , Wong Wan-Nar , Chan Kai-Ming , Leung Kwok-Sui 
Published: September 2007

Background Extracorporeal shock wave therapy is indicated for treatment of chronic injuries of soft tissues and delayed fracture healing and nonunion. No investigation has been conducted to study the effect of shock wave on delayed healing at the bone-tendon junction. Hypothesis Shock wave promotes osteogenesis, regeneration of fibrocartilage zone, and remodeling of healing tissue in delayed healing of bone-tendon junction surgical repair. Study Design Controlled laboratory study. Methods Twenty-eight mature rabbits were used for establishing a delayed healing model at the patella–patellar tendon complex after partial patellectomy and then divided into control and shock wave groups. In the shock wave group, a single shock wave treatment was given at week 6 postoperatively to the patella–patellar tendon healing complex. Seven samples were harvested at week 8 and 7 samples at week 12 for radiologic, densitometric, histologic, and mechanical evaluations. Results Radiographic measurements showed 293.4% and 185.8% more new bone formation at the patella–patellar tendon healing junction in the shock wave group at weeks 8 and 12, respectively. Significantly better bone mineral status was found in the week 12 shock wave group. Histologically, the shock wave group showed more advanced remodeling in terms of better alignment of collagen fibers and thicker and more mature regenerated fibrocartilage zone at both weeks 8 and 12. Mechanical testing showed 167.7% and 145.1% higher tensile load and strength in the shock wave group at week 8 and week 12, respectively, compared with controls. Conclusion Extracorporeal shock wave promotes osteogenesis, regeneration of fibrocartilage zone, and remodeling in the delayed bone-to-tendon healing junction in rabbits. Clinical Relevance These results provide a foundation for future clinical studies toward establishment of clinical indication for treatment of delayed bone-to-tendon junction healing.