bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal trends in colorectal cancer mortality rates (1999–2022) in the United States
Authors: Ilyas Fariha , Ahmed Eiman , Ali Hassam , Ilyas Maheen , Sarfraz Shiza , Khalid Mahnoor , Khalaf Muhammad , Mudireddy Prashant Reddy 
Published: March 2024

AbstractColorectal cancer (CRC) ranks as the third leading cause of cancer‐related deaths in the United States (U.S.). Our study aims to analyze CRC mortality patterns in the U.S., focusing on gender and age groups from 1999 to 2022. We analyzed Age‐Adjusted Mortality Rates (AAMRs) for CRC‐related deaths using the CDC Wide‐ranging Online Data for Epidemiologic Research (CDC WONDER) database and assessed differences between age and sex. CRC‐related mortality decreased significantly from 1999 to 2011 (−2.81% APC) and from 2011 to 2020 (−1.95% APC) but a not significant uptrend from 2020 to 2022 (2% APC). Males experienced a more significant decrease. Among age groups, crude mortality decreased until 2020, except in age group 45–54, which showed an annual increase in mortality of 0.9% from 2004 to 2022. Furthermore, individuals aged 75–84 and 85+ saw a nonsignificant annual increase of 1.8% and 4.5% from 2020 to 2022, respectively. Our study highlights a significant decline in age and gender‐specific CRC‐related mortality from 1999 to 2020. However, the worrisome uptrend observed in the younger age group of 45–54 emphasizes the importance of implementing targeted public health measures and evidence‐based interventions.
The PhenX Toolkit: Recommended Measurement Protocols for Social Determinants of Health Research
Authors: Ives Cataia L. , Krzyzanowski Michelle C. , Marshall Vanessa J. , Norris Keith , Cockburn Myles , Bentley‐Edwards Keisha , Mohottige Dinushika , Pollack Porter Keshia M. , Dillard Denise , Eisenberg Yochai , Jiménez Monik C. , Pérez‐Stable Eliseo J. , Jones Nancy L. , Dayal Jyoti , Maiese Deborah R. , Williams David , Hendershot Tabitha P. , Hamilton Carol M. 
Published: March 2024

AbstractHealth disparities are driven by unequal conditions in the environments in which people are born, live, learn, work, play, worship, and age, commonly termed the Social Determinants of Health (SDoH). The availability of recommended measurement protocols for SDoH will enable investigators to consistently collect data for SDoH constructs. The PhenX (consensus measures for Phenotypes and eXposures) Toolkit is a web‐based catalog of recommended measurement protocols for use in research studies with human participants. Using standard protocols from the PhenX Toolkit makes it easier to compare and combine studies, potentially increasing the impact of individual studies, and aids in comparability across literature. In 2018, the National Institute on Minority Health and Health Disparities provided support for an initial expert Working Group to identify and recommend established SDoH protocols for inclusion in the PhenX Toolkit. In 2022, a second expert Working Group was convened to build on the work of the first SDoH Working Group and address gaps in the SDoH Toolkit Collections. The SDoH Collections consist of a Core Collection and Individual and Structural Specialty Collections. This article describes a Basic Protocol for using the PhenX Toolkit to select and implement SDoH measurement protocols for use in research studies. © 2024 The Authors. Current Protocols published by Wiley Periodicals LLC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.Basic Protocol: Using the PhenX Toolkit to select and implement SDoH protocols
Mouse Models of Sepsis
Authors: Kannan Shravan Kumar , Kim Caleb Y. , Heidarian Mohammad , Berton Roger R. , Jensen Isaac J. , Griffith Thomas S. , Badovinac Vladimir P. 
Published: March 2024

AbstractHuman sepsis is a complex disease that manifests with a diverse range of phenotypes and inherent variability among individuals, making it hard to develop a comprehensive animal model. Despite this difficulty, numerous models have been developed that capture many key aspects of human sepsis. The robustness of these models is vital for conducting pre‐clinical studies to test and develop potential therapeutics. In this article, we describe four different models of murine sepsis that can be used to address different scientific questions relevant to the pathology and immune response during and after a septic event. Basic Protocol 1 details a non‐synchronous cecal ligation and puncture (CLP) model of sepsis, where mice are subjected to polymicrobial exposure through surgery at different time points within 2 weeks. This variation in sepsis onset establishes each mouse at a different state of inflammation and cytokine levels that mimics the variability observed in humans when they present in the clinic. This model is ideal for studying the long‐term impact of sepsis on the host. Basic Protocol 2 is also a type of polymicrobial sepsis, where injection of a specific amount of cecal slurry from a donor mouse into the peritoneum of recipient mice establishes immediate inflammation and sepsis without any need for surgery. Basic Protocol 3 describes infecting mice with a defined gram‐positive or ‐negative bacterial strain to model a subset of sepsis observed in humans infected with a single pathogen. Basic Protocol 4 describes administering LPS to induce sterile endotoxemia. This form of sepsis is observed in humans exposed to bacterial toxins from the environment. © 2024 The Authors. Current Protocols published by Wiley Periodicals LLC.This article was corrected on 08 July 2024. See the end of the full text for details.Basic Protocol 1: Non‐synchronous cecal ligation and punctureBasic Protocol 2: Cecal slurry model of murine sepsisBasic Protocol 3: Monomicrobial model of murine sepsisBasic Protocol 4: LPS model of murine sepsis
An Integrated Process Analysis for Producing Glycerol Carbonate from CO2 and Glycerol
Authors: Del‐Mazo‐Alvarado Octavio , Prieto Carlos , Sánchez Antonio , Ramírez‐Márquez César , Bonilla‐Petriciolet Adrián , Martín Mariano 
Published: March 2024

AbstractGlycerol carbonate (GC) is one of the most attractive green chemicals involved in several applications such as polymer synthesis, e. g., the production of polyurethanes and polycarbonates. This relevant chemical can be produced, in a green way, using CO2 (from carbon capture) and glycerol (a byproduct from biodiesel manufacturing). Therefore, in this work, a comprehensive analysis of the GC production process is conducted based on the following synthesis route: urea‐dimethyl carbonate‐GC using carbon dioxide and glycerol as the main raw materials where the synthesis pathway was efficiently integrated using Aspen Plus. A techno‐economic analysis was performed in order to estimate the required capital investment and operating cost for the whole GC process, providing insights on individual capital cost requirements for the urea, dimethyl carbonate, and GC production sections. A total capital cost of $192.1 MM, and a total operating cost of $225.7 MM/y were estimated for the process. The total annualized cost was estimated as $1,558 USD/t of GC produced, competitive with current market price.
S100Z is expressed in a lateral subpopulation of olfactory receptor neurons in the main olfactory system of Xenopus laevis
Authors: Kahl Melina , Offner Thomas , Trendel Alena , Weiss Lukas , Manzini Ivan , Hassenklöver Thomas 
Published: March 2024

AbstractIn contrast to other S100 protein members, the function of S100 calcium‐binding protein Z (S100Z) remains largely uncharacterized. It is expressed in the olfactory epithelium of fish, and it is closely associated with the vomeronasal organ (VNO) in mammals. In this study, we analyzed the expression pattern of S100Z in the olfactory system of the anuran amphibian Xenopus laevis. Using immunohistochemistry in whole mount and slice preparations of the larval olfactory system, we found exclusive S100Z expression in a subpopulation of olfactory receptor neurons (ORNs) of the main olfactory epithelium (MOE). S100Z expression was not co‐localized with TP63 and cytokeratin type II, ruling out basal cell and supporting cell identity. The distribution of S100Z‐expressing ORNs was laterally biased, and their average number was significantly increased in the lateral half of the olfactory epithelium. The axons of S100Z‐positive neurons projected exclusively into the lateral and intermediate glomerular clusters of the main olfactory bulb (OB). Even after metamorphic restructuring of the olfactory system, S100Z expression was restricted to a neuronal subpopulation of the MOE, which was then located in the newly formed middle cavity. An axonal projection into the ventro‐lateral OB persisted also in postmetamorphic frogs. In summary, S100Z is exclusively associated with the main olfactory system in the amphibian Xenopus and not with the VNO as in mammals, despite the presence of a separate accessory olfactory system in both classes.
Metal‐Free ipso‐Halocyclization of N‐Arylpropynamides Using Hypervalent Iodine(III) Reagents under Aqueous Condition
Authors: Jangir Pankaj , Ram Bajya Kalu , Pathare Akshay S. , Sodoor Mohammad , Saini Rinku , Purohit Mukesh , Selvakumar Sermadurai 
Published: March 2024

AbstractWe report, an intramolecular ipso‐halocyclization of N‐arylpropynamides using readily available hypervalent iodine reagent as mild oxidant and alkali halides like KCl, KBr, and KI as the halogen source. Using this method, a broad range of valuable halogenated spiro[4.5]trienones can be obtained in an excellent yield at room temperature. Notably, this protocol doesn't require para‐substituents such as methoxy or fluoro group on the N‐aryl ring. Also, this reaction takes place in the absence of any metal catalyst under aqueous conditions and exhibits a broad substrate scope with high functional group tolerance. A plausible reaction mechanism is proposed based on control experiments.
Adjustable graphene disk‐based THz absorber for biomedical sensing: Theoretical description
Authors: Soltani Zanjani Masoud , Sadrnia Hassan 
Published: March 2024

AbstractAs a basic building block, the THz wave absorber has intense imaging, sensing, and nondestructive testing applications. There are several methods for tuning THz absorbers, including electricity modulation, light modulation, mechanical tuning, using phase change materials, liquid crystal, flexible materials, MEMS technology, and thermally tuning vanadium dioxide. The choice of tuning method depends on the specific application and the desired performance characteristics of the THz absorber. In this work, we report a theoretical description of mechanically tunable THz absorber based on overlapping periodic arrays of graphene nano‐disks. The basis of this work is based on the movement of a dielectric surface covered on both sides with graphene disks. This surface moves on a fixed plane while the distance between these two surfaces is free space. Also, the fixed surface consists of a relatively thick layer of gold at the bottom, dielectric on it, and graphene disk patterns on the dielectric. Now, by moving the movable surface in the horizontal direction, it is possible to adjust the amount of absorption in different frequencies of the terahertz (THz) band. Additionally, an equivalent RLC circuit model is developed and theoretical results match with simulated data. The proposed mechanically tunable THz absorber can be exploited in various emerging applications such as sensing due to its capability of covering all of the THz gap and beyond with multiple absorption peaks.
Recent advances in bacteria‐based platforms for inflammatory bowel diseases treatment
Authors: Lu Jiaoying , Shen Xinyuan , Li Hongjun , Du Juan 
Published: March 2024

AbstractInflammatory bowel disease (IBD) is a recurring chronic inflammatory disease. Current treatment strategies are aimed at alleviating clinical symptoms and are associated with gastrointestinal or systemic adverse effects. New delivery strategies are needed for the treatment of IBD. Bacteria are promising biocarriers, which can produce drugs in situ and sense the gut in real time. Herein, we focus on recent studies of engineered bacteria used for IBD treatment and introduce the application of engineered bacteria in the diagnosis. On this basis, the current dilemmas and future developments of bacterial delivery systems are discussed.
Systemic amyloid A amyloidosis of the bladder after transurethral resection of urothelial carcinoma
Authors: Yamashita Kaori , Yoshida Keita , Nakazawa Tadao , Kubota Satoshi , Shiseki Takahiro , Sekido Eri , Inui Masashi 
Published: March 2024

IntroductionAmyloid A amyloidosis of the bladder is not a major disease. We report a patient with systemic amyloid A amyloidosis of the bladder after transurethral resection of urothelial carcinoma.Case presentationAn 87‐year‐old Japanese man had bladder carcinoma. He was followed up regularly with cystoscopy. Cystoscopy revealed multiple polypoid tumors 6 months after the first transurethral resection of urothelial carcinoma. Pathologic specimens contained the amyloid A component. He had hypertrophic cardiomyopathy, valvular disorders, and arrhythmias. His cardiac disease may have resulted from amyloid A amyloidosis. We speculated the patient had systemic amyloid A amyloidosis of the heart and bladder.ConclusionWe determined the type of amyloidosis via a biopsy of the bladder tumors. Our patient had cardiac disease. Therefore, systemic amyloid A amyloidosis could have caused his cardiac disease. The pathologic findings of bladder tumors can contribute to detecting systemic amyloid A amyloidosis.
When nanozymes meet deoxyribonucleic acid: Understanding their interactions and biomedical diagnosis applications
Authors: Liang Hao , Chen Xinyu , Bu Zhijian , Bai Qinqin , Liu Jinjin , Tian Qingzhen , Tang Zheng , Li Shu , Diao Qiaoqiao , Niu Xiangheng 
Published: March 2024

AbstractAs emerging alternatives to natural enzymes, nanoscale materials featuring enzyme‐like catalytic behaviors (nanozymes) exhibit some attractive merits including robust activity, low cost, and easy‐to‐regulate performance. These merits have enabled them to be intensively used in the biomedical field in recent years. To remedy the lack of catalytic selectivity in most nanozymes, deoxyribonucleic acid (DNA) chains with specific recognition functions are utilized to integrate with nanozymes to produce various nanozyme–DNA combinations via adsorption/desorption. In the formed combinations, the DNA component provides the molecular/ionic recognition role, and the nanozyme part offers response with catalytically amplified signals, enabling them to detect analytes and biomarkers selectively and sensitively. To highlight this interesting topic, here we made a critical review of the interactions between nanozymes and DNA and their applications in biosensing and disease diagnosis. First, strategies for the conjugation of DNA chains onto nanozyme surface were introduced briefly. Then, the interactions between DNA and nanozymes were summarized in detail, where flexible modulations of nanozyme activity by DNA adsorption/desorption as well as various factors were analyzed, and potential impacts caused by nanozymes on the recognition characteristics of DNA chains were pointed out. After that, typical applications of DNA‐mediated nanozyme modulation in toxic ion sensing, health risk factor monitoring, and biomedical diagnosis were introduced. In the end, prospects of the combination of nanozymes and DNA chains were presented, and future challenges of the emerging field were also discussed, to attract more interest and effort to advance this promising area.
Carbon Considerations for Systems Evolution
Authors: Flanigan David , Robinson Kevin 
Published: March 2024

ABSTRACTIn the early stages of systems development, systems engineers will typically evaluate alternatives based on performance, cost, risk, and schedule to evaluate the solution space of alternatives. While these criteria have proven to be successful, there is growing interest in the analysis of carbon costs as well to contribute to the decision making. These decision criteria are very good to help the decision maker select the best alternative within the solution space in which to develop a system concept. We offer another criterion for consideration to account for carbon expenditure throughout the systems engineering lifecycle. We believe that including this dimension can influence decision makers to evaluate a richer portion of the solution space. This approach is developed and exercised with a notional example.
Oral ribose supplementation in dystroglycanopathy: A single case study
Authors: Thewissen R. M. J. , Post M. A. , Maas D. M. , Veizaj R. , Wagenaar I. , Alsady M. , Kools J. , Bouman K. , Zweers H. , Meregalli P. G. , van der Kooi A. J. , van Doorn P. A. , Groothuis J. T. , Lefeber D. J. , Voermans N. C. 
Published: March 2024

AbstractThree forms of muscular dystrophy‐dystroglycanopathies are linked to the ribitol pathway. These include mutations in the isoprenoid synthase domain‐containing protein (ISPD), fukutin‐related protein (FKRP), and fukutin (FKTN) genes. The aforementioned enzymes are required for generation of the ribitol phosphate linkage in the O‐glycan of alpha‐dystroglycan. Mild cases of dystroglycanopathy present with slowly progressive muscle weakness, while in severe cases the eyes and brain are also involved. Previous research showed that ribose increased the intracellular concentrations of cytidine diphosphate‐ribitol (CDP‐ribitol) and had a therapeutic effect. Here, we report the safety and effects of oral ribose supplementation during 6 months in a patient with limb girdle muscular dystrophy type 2I (LGMD2I) due to a homozygous FKRP mutation. Ribose was well tolerated in doses of 9 g or 18 g/day. Supplementation with 18 g of ribose resulted in a decrease of creatine kinase levels of 70%. Moreover, metabolomics showed a significant increase in CDP‐ribitol levels with 18 g of ribose supplementation (p < 0.001). Although objective improvement in clinical and patient‐reported outcome measures was not observed, the patient reported subjective improvement of muscle strength, fatigue, and pain. This case study indicates that ribose supplementation in patients with dystroglycanopathy is safe and highlights the importance for future studies regarding its potential effects.
Vibrational study to analyze the A‐site cation disordering in four‐layered Aurivillius oxides ABi4Ti4O15 (ACa, Sr, Ba)
Authors: Tripathi Archana , Gupta Hem Chandra , Jindal Ruby 
Published: March 2024

AbstractThe Raman and infrared (IR) wavenumbers were computed for the Aurivillius structure ABi4Ti4O15 (ABT) (ACa, Sr, Ba) in an orthorhombic space group (A21am, No. 36, C122v) using normal coordinate analysis. This study aimed to investigate the impact of A‐site cations on vibrational phonons. The analysis of zone center phonons primarily involved numerous stretching and bending bonds, serving as force constants. These force constants were utilized to assign the calculated wavenumbers in the examined phase for the first time. The theoretical findings in this paper exhibited a favorable correlation with the wavenumbers reported in the literature. Comparisons of force constants, bond lengths, and wavenumbers were conducted to elucidate A‐site cation disordering in these intricate compounds. The outcomes indicated that, in the studied complexes, the Sr atom exhibited an ideal radius for fitting into the structure. The mass of the A‐site cations was identified as a factor contributing to tilts in the octahedra. An additional analysis was carried out to assess the impact of A‐cations on both the affected equatorial and axial bonds, providing a clearer understanding of the structure. Outer octahedra displayed greater sensitivity to A‐site cations compared with inner octahedra. A study of potential energy distribution was also conducted in this work to determine the significance of each force constant in all calculated wavenumbers. It was observed that higher wavenumbers were predominantly influenced by vibrations in oxygen atoms, while lower wavenumbers were mainly affected by A‐site cations. Notably, overdamping was observed in the lowest frequency of the BBT compound.
Stability of n‐hexadecane phase change material emulsions using sugar‐based surfactants and the HLD platform
Authors: Shayanmehr Mohammadesmaiel , Eslami Fatemeh 
Published: March 2024

AbstractStoring thermal energy and using renewable energy are some of the most important challenges humanity faces today. Using phase change materials (PCM) is a suitable solution to prevent heat loss. PCM emulsions (PCMEs) have several advantages and are specifically applied in heat exchangers. Here, the formulation of these emulsions, the type of surfactants, and their composition based on freeze–thaw cycle stability are investigated. The Hydrophilic–Lipophilic‐Deviation (HLD) platform is used for this purpose. Considering the importance of stability during temperature changes in PCMEs, three types of surfactants that have different behaviors with respect to temperature are used: ethoxylates, ionics, and sugar‐based surfactants. By performing freeze–thaw cycles on emulsions made by individual surfactants, after 10 freeze–thaw cycles it was observed that the oil separation in each of the samples containing polysorbate80, AOT, lauryl‐myristyl‐alcohol‐polyethylene‐glycol‐ether, SDS, sorbitan‐monooleate, and decylglucoside occurred at the 2nd, 4th, 6th, 7th, 8th, and 10th‐cycle, respectively. Therefore, the sorbitan‐monooleate and decylglucoside had better freeze–thaw cycle stability compared to the others because of their non‐sensitivity to temperature. We also applied the emulsion cycle stability with two combinations of surfactants: (1) polysorbate80 and sorbitan‐monooleate, (2) decylglucoside and sorbitan‐monooleate. The former, despite the effect of temperature, showed no oil phase separation in the nine freeze–thaw cycles, but in the latter, the oil phase separation occurred in the 5th‐cycle. This study shows that synergism of surfactants is the most important factor in the stability of emulsions. To better explore these emulsion systems, the storage stability, freeze–thaw stability, droplet morphology, and viscosity tests were performed on different samples at various HLD values.
Ultrasound‐enhanced covalent reaction of gliadin: the inhibition of antigenicity and its potential mechanisms
Authors: Wang Junrong , Cao Jiaxing , Xu Ning , Meng Taihe , Zhang Guozhi , Zhang Yu 
Published: March 2024

AbstractBACKGROUNDWheat proteins can be divided into water/salt‐soluble protein (albumin/globulin) and water/salt‐insoluble protein (gliadins and glutenins (Glu)) according to solubility. Gliadins (Glia) are one of the major allergens in wheat. The inhibition of Glia antigenicity by conventional processing techniques was not satisfactory.RESULTSIn this study, free radical oxidation was used to induce covalent reactions. The effects of covalent reactions by high‐intensity ultrasound (HIU) of different powers was compared. The enhancement of covalent grafting effectiveness between gliadin and (−)‐epigallo‐catechin 3‐gallate (EGCG) was confirmed by sodium dodecyl sulfate–polyacrylamide gel electrophoresis, matrix‐assisted laser desorption/ionization–time‐of‐flight–mass spectrometry and Folin–Ciocalteu tests. HIU caused protein deconvolution and disrupted the intrastrand disulfide bonds that maintain the tertiary structure, causing a shift in the side chain structure, as proved by Fourier, fluorescence and Raman spectroscopic analysis. Comparatively, the antigenic response of the conjugates formed in the sonication environment was significantly weaker, while these conjugates were more readily hydrolyzed and less antigenic during simulated gastrointestinal fluid digestion.CONCLUSIONHIU‐enhanced free radical oxidation caused further transformation of the spatial structure of Glia, which hid or destroyed the antigenic epitope, effectively inhibiting protein antigenicity. This study widened the application of polyphenol modification in the inhibition of wheat allergens. © 2024 Society of Chemical Industry.