bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative effectiveness of several adjuvant therapies after hepatectomy for hepatocellular carcinoma patients with microvascular invasion
Authors: Pei Yin-Xuan , Su Chen-Guang , Liao Zheng , Li Wei-Wei , Wang Zi-Xiang , Liu Jin-Long 
Published: February 2024

BACKGROUND
For resectable hepatocellular carcinoma (HCC), radical hepatectomy is commonly used as a curative treatment. However, postoperative recurrence significantly diminishes the overall survival (OS) of HCC patients, especially with microvascular invasion (MVI) as an independent high-risk factor for recurrence. While some studies suggest that postoperative adjuvant therapy may decrease the risk of recurrence following liver resection in HCC patients, the specific role of adjuvant therapies in those with MVI remains unclear.
AIM
To conduct a network meta-analysis (NMA) to evaluate the efficacy of various adjuvant therapies and determine the optimal adjuvant regimen.
METHODS
A systematic literature search was conducted on PubMed, EMBASE, and Web of Science until April 6, 2023. Studies comparing different adjuvant therapies or comparing adjuvant therapy with hepatectomy alone were included. Hazard ratios (HRs) with 95% confidence intervals were used to combine data on recurrence free survival and OS in both pairwise meta-analyses and NMA.
RESULTS
Fourteen eligible trials (2268 patients) reporting five different therapies were included. In terms of reducing the risk of recurrence, radiotherapy (RT) [HR = 0.34 (0.23, 0.5); surface under the cumulative ranking curve (SUCRA) = 97.7%] was found to be the most effective adjuvant therapy, followed by hepatic artery infusion chemotherapy [HR = 0.52 (0.35, 0.76); SUCRA = 65.1%]. Regarding OS improvement, RT [HR: 0.35 (0.2, 0.61); SUCRA = 93.1%] demonstrated the highest effectiveness, followed by sorafenib [HR = 0.48 (0.32, 0.69); SUCRA = 70.9%].
CONCLUSION
Adjuvant therapy following hepatectomy may reduce the risk of recurrence and provide a survival benefit for HCC patients with MVI. RT appears to be the most effective adjuvant regimen.
Poor oral health was associated with higher risk of gastric cancer: Evidence from 1431677 participants
Authors: Liu Fei , Tang Shi-Jun , Li Zi-Wei , Liu Xu-Rui , Lv Quan , Zhang Wei , Peng Dong 
Published: February 2024

BACKGROUND
In recent years, the association between oral health and the risk of gastric cancer (GC) has gradually attracted increased interest. However, in terms of GC incidence, the association between oral health and GC incidence remains controversial. Periodontitis is reported to increase the risk of GC. However, some studies have shown that periodontitis has no effect on the risk of GC. Therefore, the present study aimed to assess whether there is a relationship between oral health and the risk of GC.
AIM
To assess whether there was a relationship between oral health and the risk of GC.
METHODS
Five databases were searched to find eligible studies from inception to April 10, 2023. Newcastle-Ottawa Scale score was used to assess the quality of included studies. The quality of cohort studies and case-control studies were evaluated separately in this study. Incidence of GC were described by odds ratio (OR) and 95% confidence interval (CI). Funnel plot was used to represent the publication bias of included studies. We performed the data analysis by StataSE 16.
RESULTS
A total of 1431677 patients from twelve included studies were enrolled for data analysis in this study. According to our analysis, we found that the poor oral health was associated with higher risk of GC (OR = 1.15, 95%CI: 1.02-1.29; I 2 = 59.47%, P = 0.00 < 0.01). Moreover, after subgroup analysis, the outcomes showed that whether tooth loss (OR = 1.12, 95%CI: 0.94-1.29; I 2 = 6.01%, P > 0.01), gingivitis (OR = 1.19, 95%CI: 0.71-1.67; I 2 = 0.00%, P > 0.01), dentures (OR = 1.27, 95%CI: 0.63-1.19; I 2 = 68.79%, P > 0.01), or tooth brushing (OR = 1.25, 95%CI: 0.78-1.71; I 2 = 88.87%, P > 0.01) had no influence on the risk of GC. However, patients with periodontitis (OR = 1.13, 95%CI: 1.04-1.23; I 2 = 0.00%, P < 0.01) had a higher risk of GC.
CONCLUSION
Patients with poor oral health, especially periodontitis, had a higher risk of GC. Patients should be concerned about their oral health. Improving oral health might reduce the risk of GC.
Postoperative encapsulated hemoperitoneum in a patient with gastric stromal tumor treated by exposed endoscopic full-thickness resection: A case report
Authors: Lu Hui-Fei , Li Jing-Jing , Zhu De-Bin , Mao Li-Qi , Xu Li-Fen , Yu Jing , Yao Lin-Hua 
Published: February 2024

BACKGROUND
Gastric stromal tumors, originating from mesenchymal tissues, are one of the most common tumors of the digestive tract. For stromal tumors originating from the muscularis propria, compared with conventional endoscopic submucosal dissection (ESD), endoscopic full-thickness resection (EFTR) can remove deep lesions and digestive tract wall tumors completely. However, this technique has major limitations such as perforation, postoperative bleeding, and post-polypectomy syndrome. Herein, we report a case of postoperative serous surface bleeding which formed an encapsulated hemoperitoneum in a patient with gastric stromal tumor that was treated with exposed EFTR. Feasible treatment options to address this complication are described.
CASE SUMMARY
A 47-year-old male patient had a hemispherical protrusion found during gastric endoscopic ultrasonography, located at the upper gastric curvature adjacent to the stomach fundus, with a smooth surface mucosa and poor mobility. The lesion was 19.3 mm × 16.1 mm in size and originated from the fourth ultrasound layer. Computed tomography (CT) revealed no significant evidence of lymph node enlargement or distant metastasis. Using conventional ESD technology for mucosal pre-resection, exposed EFTR was performed to resect the intact tumor in order to achieve a definitive histopathological diagnosis. Based on its morphology and immunohistochemical expression of CD117 and DOG-1, the lesion was proven to be consistent with a gastric stromal tumor. Six days after exposed EFTR, CT showed a large amount of encapsulated fluid and gas accumulation around the stomach. In addition, gastroscopy suggested intracavitary bleeding and abdominal puncture drainage indicated serosal bleeding. Based on these findings, the patient was diagnosed with serosal bleeding resulting in encapsulated abdominal hemorrhage after exposed EFTR for a gastric stromal tumor. The patient received combined treatments, such as hemostasis under gastroscopy, gastrointestinal decompression, and abdominal drainage. All examinations were normal within six months of follow-up.
CONCLUSION
This patient developed serous surface bleeding in the gastric cavity following exposed EFTR. Serosal bleeding resulting in an encapsulated hemoperitoneum is rare in clinical practice. The combined treatment may replace certain surgical techniques.
Early endoscopic management of an infected acute necrotic collection misdiagnosed as a pancreatic pseudocyst: A case report
Authors: Zhang Hong-Ying , He Chen-Cong 
Published: February 2024

BACKGROUND
Infected acute necrotic collection (ANC) is a fatal complication of acute pancreatitis with substantial morbidity and mortality. Drainage plays an exceedingly important role as the first step in invasive intervention for infected necrosis; however, there is great controversy about the optimal drainage time, and better treatment should be explored.
CASE SUMMARY
We report the case of a 43-year-old man who was admitted to the hospital with severe intake reduction due to early satiety 2 wk after treatment for acute pancreatitis; conservative treatment was ineffective, and a pancreatic pseudocyst was suspected on contrast-enhanced computed tomography (CT). Endoscopic ultrasonography (EUS) suggested hyperechoic necrotic tissue within the cyst cavity. The wall was not completely mature, and the culture of the puncture fluid was positive for A-haemolytic Streptococcus. Thus, the final diagnosis of ANC infection was made. The necrotic collection was not walled off and contained many solid components; therefore, the patient underwent EUS-guided aspiration and lavage. Two weeks after the collection was completely encapsulated, pancreatic duct stent drainage via endoscopic retrograde cholangiopancreatography (ERCP) was performed, and the patient was subsequently successfully discharged. On repeat CT, the pancreatic cysts had almost disappeared during the 6-month follow-up period after surgery.
CONCLUSION
Early EUS-guided aspiration and lavage combined with late ERCP catheter drainage may be effective methods for intervention in infected ANCs.
Ileal collision tumor associated with gastrointestinal bleeding: A case report and review of literature
Authors: Wu Yu-Qi , Wang Hong-Yan , Shao Mu-Min , Xu Lin , Jiang Xiao-Yan , Guo Shao-Ju 
Published: February 2024

BACKGROUND
Collision tumors involving the small intestine, specifically the combination of a hamartomatous tumor and a lipoma, are extremely rare. To our knowledge, no previous case report has described a collision tumor composed of two benign tumors of different origins in the small intestine.
CASE SUMMARY
Here, we present the case of an 82-year-old woman who presented with hemorrhagic shock and was found to have a mass measuring approximately 50 mm × 32 mm × 30 mm in the terminal ileum. Based on computed tomography scan findings, the mass was initially suspected to be a lipoma. A subsequent colonoscopy revealed a pedunculated submucosal elevation consisting of two distinct parts with a visible demarcation line. A biopsy of the upper portion suggested a juvenile polyp (JP). Owing to the patient’s advanced age, multiple comorbidities, and poor surgical tolerance, a modified endoscopic submucosal dissection was performed. Histopathological examination of the excised mucosal mass revealed a lipoma at the base and a JP at the top, demonstrating evidence of rupture and associated bleeding. The patient’s overall health remained satisfactory, with no recurrence of hematochezia during the six-month follow-up period.
CONCLUSION
This case report provides new evidence for the understanding of gastrointestinal collision tumors, emphasizing their diverse clinical presentations and histopathological characteristics. It also offers diagnostic and therapeutic insights as well as an approach for managing benign collision tumors.
Silencing of Jumonji domain-containing 1C inhibits the osteogenic differentiation of bone marrow mesenchymal stem cells via nuclear factor-κB signaling
Authors: Li Jing-Yi , Wang Ting-Ting , Ma Li , Zhang Yu , Zhu Di 
Published: February 2024

BACKGROUND
Osteoporosis is a common metabolic bone disorder induced by an imbalance between osteoclastic activity and osteogenic activity. During osteoporosis, bone mesenchymal stem cells (BMSCs) exhibit an increased ability to differentiate into adipocytes and a decreased ability to differentiate into osteoblasts, resulting in bone loss. Jumonji domain-containing 1C (JMJD1C ) has been demonstrated to suppress osteoclastogenesis.
AIM
To examine the effect of JMJD1C on the osteogenesis of BMSCs and the potential underlying mechanism.
METHODS
BMSCs were isolated from mouse bone marrow tissues. Oil Red O staining, Alizarin red staining, alkaline phosphatase staining and the expression of adipogenic and osteogenic-associated genes were assessed to determine the differentiation of BMSCs. Bone marrow-derived macrophages (BMMs) were incubated with receptor activator of nuclear factor-kappa Β ligand to induce osteoclast differentiation, and osteoclast differentiation was confirmed by tartrate-resistant acid phosphatase staining. Other related genes were measured via reverse transcription coupled to the quantitative polymerase chain reaction and western blotting. Enzyme-linked immunosorbent assays were used to measure the levels of inflammatory cytokines, including tumor necrosis factor alpha, interleukin-6 and interleukin-1 beta.
RESULTS
The osteogenic and adipogenic differentiation potential of BMSCs isolated from mouse bone marrow samples was evaluated. JMJD1C mRNA and protein expression was upregulated in BMSCs after osteoblast induction, while p-nuclear factor-κB (NF-κB) and inflammatory cytokines were not significantly altered. Knockdown of JMJD1C repressed osteogenic differentiation and enhanced NF-κB activation and inflammatory cytokine release in BMSCs. Moreover, JMJD1C expression decreased during BMM osteoclast differentiation.
CONCLUSION
The JMJD1C /NF-κB signaling pathway is potentially involved in BMSC osteogenic differentiation and may play vital roles in the pathogenesis of osteoporosis.
VX-509 attenuates the stemness characteristics of colorectal cancer stem-like cells by regulating the epithelial-mesenchymal transition through Nodal/Smad2/3 signaling
Authors: Yuan Yun , Zhang Xu-Fan , Li Yu-Chen , Chen Hong-Qing , Wen Tian , Zheng Jia-Lian , Zhao Zi-Yi , Hu Qiong-Ying 
Published: February 2024

BACKGROUND
Colorectal cancer stem cells (CCSCs) are heterogeneous cells that can self-renew and undergo multidirectional differentiation in colorectal cancer (CRC) patients. CCSCs are generally accepted to be important sources of CRC and are responsible for the progression, metastasis, and therapeutic resistance of CRC. Therefore, targeting this specific subpopulation has been recognized as a promising strategy for overcoming CRC.
AIM
To investigate the effect of VX-509 on CCSCs and elucidate the underlying mechanism.
METHODS
CCSCs were enriched from CRC cell lines by in conditioned serum-free medium. Western blot, Aldefluor, transwell and tumorigenesis assays were performed to verify the phenotypic characteristics of the CCSCs. The anticancer efficacy of VX-509 was assessed in HCT116 CCSCs and HT29 CCSCs by performing cell viability analysis, colony formation, sphere formation, flow cytometry, and western blotting assessments in vitro and tumor growth, immunohistochemistry and immunofluorescence assessments in vivo .
RESULTS
Compared with parental cells, sphere cells derived from HCT116 and HT29 cells presented increased expression of stem cell transcription factors and stem cell markers and were more potent at promoting migration and tumorigenesis, demonstrating that the CRC sphere cells displayed CSC features. VX-509 inhibited the tumor malignant biological behavior of CRC-stem-like cells, as indicated by their proliferation, migration and clonality in vitro , and suppressed the tumor of CCSC-derived xenograft tumors in vivo . Besides, VX-509 suppressed the CSC characteristics of CRC-stem-like cells and inhibited the progression of epithelial-mesenchymal transition (EMT) signaling in vitro . Nodal was identified as the regulatory factor of VX-509 on CRC stem-like cells through analyses of differentially expressed genes and CSC-related database information. VX-509 markedly downregulated the expression of Nodal and its downstream phosphorylated Smad2/3 to inhibit EMT progression. Moreover, VX-509 reversed the dedifferentiation of CCSCs and inhibited the progression of EMT induced by Nodal overexpression.
CONCLUSION
VX-509 prevents the EMT process in CCSCs by inhibiting the transcription and protein expression of Nodal, and inhibits the dedifferentiated self-renewal of CCSCs.
Formulation of Recipes and Organoleptic Properties of Tinuktuk as Simalungun Traditional Food
Authors: Tarigan Novriani , Silalahi Jansen , Sihotang Urbanus 
Published: February 2024

Tinuktuk is a traditional spice sauce of the simalungun ethnic group. It is believed as a traditional health icon To search the best formulation of ingredients', to search the best production process and to evaluate its organoleptics properties. The search for formulation ingredients is an exploratory qualitative study with participant observation method. The organoleptic test was carried out by fifty untrained panelists on a scale of 1 (dislike) to 5 (very like). Organoleptic values ​​including taste, aroma, texture and color Six formulations of tinuktuk, containing of 8 to 15 ingredients. Three kinds of production process: first by mashing the fresh ingredients and then roasting them. The second process is mashing the rosated material. The third is a combination of both processes. These processes could be distingueished by the organoleptic values. The incremented values resulted from T5, T1, T3 formulations. T3 formula contains 15 ingredients use the third production process. This value could be taken as a reference for tinuktuk standard.
Pengembangan Sistem Pemantauan Tinggi Gelombang Air pada Model Tsunami Menggunakan Sensor Ultrasonik HC-SR04 Berbantuan Arduino
Authors: Hasbullah Hasbullah , Pramudya Yudhiakto 
Published: February 2024

Data fluktuasi ketinggian permukaan air laut akibat longsoran suatu daerah sangat penting dalam menganalisis dampak yang ditimbulkan pada suatu daerah yang rawan terjadi tsunami longsoran. Untuk mengembangkan sistem pemantauan ketinggian gelombang air pada model tsunami digunakan Arduino Uno dan Sensor Ultrasonik HC-SR04 untuk mengukur durasi waktu gelombang ultrasonik memantul dari permukaan air, sehingga dapat diketahui jarak berdasarkan cepat rambat bunyi di udara. Silinder pejal digelindingkan pada sebuah bidang miring sebagai pemicu awal gelombang pada air. Ketinggian gelombang akan terukur pada empat buah sensor yang diletakkan di atas permukaan air. Add-ins Data Streamer pada Aplikasi Microsoft Excel digunakan untuk merekam data hasil pengukuran dari perangkat arduino. Pada sudut kemiringan 15,32Â° diperoleh kecepatan rata-rata 111,18 cm/s dengan ketinggian gelombang rata-rata 0,42 cm. Pada sudut kemiringan 16,86Â° diperoleh kecepatan rata-rata 113,33 cm/s dengan ketinggian gelombang rata-rata 0,64 cm. Pada sudut kemiringan 18,43Â° diperoleh kecepatan rata-rata 132,22 cm/s dengan ketinggian gelombang rata-rata 0,83 cm. Dari hasil perhitungan ketinggian rata-rata gelombang air yang terukur akan cenderung meningkat pada variasi kemiringan sudut 15,32Â° hingga sudut 18,43Â°.
Pengaruh Komunikasi Pemasaran dan Pengalaman Pemasaran terhadap Keputusan Pembelian di Marketplace Shopee
Authors: Widyaratna Lianita , Purwantoro Handik , Pamikiran Vero Nathalniel 
Published: February 2024

This study aims to determine the effect of marketing communications and marketing experience on purchasing decisions on the Shopee marketplace, partially or jointly. The population in this study were Class C Students of STIE Kertanegara Malang Class of 2020 – 2022. The sampling technique used non-probability sampling with purposive sampling technique. The sample used in this research was taken using the Slovin Formula and found 55 respondents. The method used in this study is a quantitative research approach method. This study used multiple linear regression analysis with data collection using a questionnaire with a Likert scale. The results of the study partially using the t test show that marketing communications and marketing experience have an effect on purchasing decisions. For research results simultaneously or together marketing communications and marketing experience also influence purchasing decisions on the Shopee marketplace by 43.5%.Keywords: Marketing Communication, Marketing Experience, Purchase DecisionAbstrakPenelitian ini bertujuan untuk mengetahui Pengaruh komunikasi pemasaran dan pengalaman pemasaran terhadap keputusan pembelian di marketplace Shopee , secara sebagian maupun bersama-sama. Populasi dalam penelitian ini adalah Mahasiswa STIE Kertanegara Malang kelas C Angkatan 2020 - 2022. Teknik pengambilan sampel menggunakan non-probability sampling dengan teknik purposive sampling. Sampel yang digunakan dalam penelitan ini diambil menggunakan Rumus Slovin didapatkan 55 responden. Metode yang digunakan pada penelitian ini adalah metode pendekatan penelitian kuantitatif. Penelitian ini menggunakan analisis regresi linier berganda dengan pengumpulan data menggunakan kuesioner dengan skala likert. Hasil penelitian secara sebagian menggunakan uji t menunjukkan bahwa komunikasi pemasaran dan pengalaman pemasaran bepengaruh terhadap keputusan pembelian. Untuk hasil penelitian secara simultan atau bersama-sama komunikasi pemasaran dan pengalaman pemasaran juga berpengaruh terhadap keputusan pembelian di marketplace Shopee sebesar 43,5%.Kata kunci: Komunikasi Pemasaran, Pengalaman Pemasaran , Keputusan Pembelian
Pengaruh Kesejateraan Pegawai, Kepuasan Kerja, dan Komitmen Organisasi terhadap Kinerja Pegawai pada Dinas Lingkungan Hidup Kota Malang
Authors: Dwiningsih Sri , Rohman Fatkur 
Published: February 2024

ABSTRACT This study aims to determine the effect of Employee Welfare, Job Satisfaction, and Organizational Commitment on Employee Performance at the Malang City Environmental Service. The method used by the author in conducting this research is descriptive analysis method and multiple linear regression analysis. Data processing was carried out using IBM SPSS STATISIC 21. The population of this study were daily employees of the Malang City Environmental Service with the number of samples taken according to the researcher's criteria of 67 employees. The results of the partial study of the Employee Welfare variable have a significant effect on Employee Performance, the Job Satisfaction variable has no significant effect on Employee Performance, and the Organizational Commitment variable has no significant effect on Employee Performance at DLH Malang City, simultaneously the variable Employee Welfare, Job Satisfaction, and Organizational Commitment has a significant effect on employee performance at DLH Malang City. Keywords: Employee Performance, Employee Welfare, Job Satisfaction, and Organizational Commitment