bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the effect of dietary vegetable consumption on reducing risk of transitional cell carcinoma of the urinary bladder in Scottish Terriers
Authors: Raghavan Malathi , Knapp Deborah W. , Bonney Patty L. , Dawson Marcia H. , Glickman Lawrence T. 
Published: December 2005

Abstract

Objective—To evaluate the effects of vegetable consumption
and vitamin supplementation on the risk of
developing transitional cell carcinoma (TCC) of the urinary
bladder in Scottish Terriers.

Design—Case-control study.

Animals—92 adult Scottish Terriers with TCC (cases)
and 83 Scottish Terriers with other conditions (controls).

Procedure—Owners of dogs with TCC completed a
questionnaire regarding their dogs' diet and intake of vitamin
supplements in the year prior to diagnosis of TCC;
owners of control dogs completed the questionnaire for
a comparable time period. The risk (odds ratio [OR]) of
developing TCC associated with diet and vitamin supplementation
was determined by use of logistic regression.

Results—After adjustment for age, weight, neuter status,
and coat color, there was an inverse association
between consumption of vegetables at least 3
times/wk (OR, 0.30; 95% confidence interval [CI], 0.15
to 0.62) and risk of developing TCC. For individual vegetable
types, the risk of developing TCC was inversely
associated with consumption of green leafy vegetables
(OR, 0.12; 95% CI, 0.01 to 0.97) and yellow-orange vegetables
(OR, 0.31; 95% CI, 0.14 to 0.70). Consumption
of cruciferous vegetables was not significantly associated
with a similar reduction in risk of developing TCC
(OR, 0.22; CI, 0.04 to 1.11). The power of the study to
detect a 50% reduction in TCC risk associated with daily
vitamin supplementation was considered low (25%).

Conclusions and Clinical Relevance—Results suggest
that consumption of certain vegetables may prevent
or slow the development of TCC in Scottish
Terriers. (J Am Vet Med Assoc 2005;227:94–100)
Evaluation of the prevalence of infections in cats after renal transplantation: 169 cases (1987–2003)
Authors: Kadar Elissa , Sykes Jane E. , Kass Philip H. , Bernsteen Lynda , Gregory Clare R. , Kyles Andrew E. 
Published: December 2005

AbstractObjective—To determine the prevalence of infections developing postoperatively, document the contribution of infection to increased risk of death, and identify risk factors associated with the development of infectious complications in cats after renal transplantation.Design—Retrospective study.Animals—169 cats that received renal allograft transplants.Procedures—Medical records of cats receiving renal transplants at the University of California from January 1987 through December 2003 were reviewed.Results—47 infections developed in 43 of 169 cats. Bacterial infections were most common (25/47 cats), followed by viral (13/47), fungal (6/47), and protozoal (3/47) infections. The median duration from transplant surgery to development of infection was 2.5 months. Infection was the second most common cause of death after acute rejection of the transplant, accounting for 14% of deaths overall. Cats with concurrent diabetes mellitus had a significantly increased risk of developing an infection after renal transplantation. Sex, increasing age, concurrent neoplasia, and previous treatment for transplant rejection were not associated with development of infection.Conclusions and Clinical Relevance—Infection was a common complication and an important cause of death or euthanasia in cats after renal transplantation. Development of diabetes mellitus after transplantation significantly increased the risk of infection. (J Am Vet Med Assoc2005;227:948–953)
Basket Trials
Authors: Beckman Robert A. 
Published: February 2025

Abstract
Basket trials are clinical trials involving borrowing information between traditional indications that share a common molecular or pathophysiologic feature that may determine the benefits of a particular therapy. The underlying assumption is that the molecular or pathophysiologic feature is more fundamental than the traditional disease classification with respect to hypotheses involving the efficacy of the corresponding therapy. Basket trials have the potential to substantially improve the efficiency of drug development and bring life‐altering medicines to patients sooner and potentially at lower cost. Basket trials have been extensively applied in the exploratory drug development setting. They have also been applied in the confirmatory setting in end‐stage patients without other options, in settings supported by exceptional scientific evidence. There remains an unmet need to develop confirmatory basket trial methods that are generalizable to earlier lines of therapy and to therapies that are effective but not necessarily exceptional. This review perspective summarizes the advantages and disadvantages of basket trials, performance metrics for their evaluation, and types of basket trials, both today and in the future.
Herbal Formula Yi‐Fei‐Jie‐Du‐Tang Regulates Epithelial‐Mesenchymal Transition and Vasculogenic Mimicry in Lung Cancer via HIF1A‐Mediated Ferroptosis
Authors: Wang Shanshan , Yang Die , Yuan Chengjia , Wu Yang , Wang Qingying , Wu Yongjian , Zhang Xiaochun 
Published: February 2025

AbstractTraditional Chinese medicine (TCM) Yi‐Fei‐Jie‐Du‐Tang (YFJDT) has shown potential in lung cancer treatment. However, the mechanisms underlying the effects of YFJDT on lung cancer remain unclear. Bioinformatics analysis is conducted to identify potential targets of YFJDT. The impact of YFJDT on hypoxia‐inducible factor 1 alpha (HIF1A), ferroptosis, and vasculogenic mimicry (VM) is investigated using xenograft tumor models and A549 cells. Additionally, A549 cells are stimulated with CoCl2 to mimic the hypoxic microenvironment of the tumor. The role of HIF1A overexpression in modulating ferroptosis is assessed. The effects of HIF1A and ferroptosis on epithelial‐mesenchymal transition (EMT) and VM in vitro are evaluated. Results: YFJDT treatment led to a concentration‐dependent decrease in HIF1A levels in xenograft tumors and A549 cells. Overexpression of HIF1A counteractes the inhibitory effects of YFJDT on proliferation, EMT, and VM in transplanted tumors. Moreover, HIF1A overexpression attenuates YFJDT‐induced lipid peroxidation and iron accumulation, indicating inhibition of ferroptosis in A549 cells. Hypoxia‐induced alterations in EMT markers and VM are reversed by YFJDT but exacerbated by HIF1A overexpression. Molecular docking identified salicylic acid and psoralen as potential components of YFJDT targeting HIF1A. YFJDT exerts anti‐tumor effects in lung cancer by downregulating HIF1A and promoting ferroptosis.
Selective Adsorption to Pathogenic Bacteria Augments Antibacterial Activity via Adjusting the Physicochemical Property of Nanoparticles
Authors: Wang Zhi‐Hao , Zhu Chaoran , Zhao Fengqin , Shi Xiufang , Liu Junjie , Shi Jinjin 
Published: February 2025

AbstractOral antibiotics are the primary method used to treat bacterial infections in clinical practice. However, the non‐selectivity of antibiotics reduces the efficacy of treatment while also tending to damage normal flora and cause dysbiosis. Obviously, it is crucial to enhance the selectivity of antibiotics against bacteria. It is possible to modulate the physicochemical properties of orally administered nanosystems to achieve selective adsorption to bacteria, thereby achieving improving bactericidal effects. A series of nanoparticles are examined bacterial adhesion characteristics focusing on five aspects: particle size, shape, charge, surface hydrophilicity, and surface modification. Selective adsorption of nanoparticles is investigated pathogenic bacteria (S. aureus as an example), normal bacteria (E. coli as an example), and probiotic bacteria (E. faecium as an example). The results show that ≈50 nm chitosan‐modified spherical Poly(lactide‐co‐glycolide) (PLGA) nanoparticles exhibit a stronger adsorption capacity for pathogenic bacteria (Staphylococcus aureus). After loading with amoxicillin, the antibacterial nanoparticles are able to destroy pathogenic bacteria without disrupting the normal intestinal bacterial flora and reducing the typical side effects of ecological disruption caused by broad‐spectrum antibiotics. Thus, this work presents a convenient and versatile strategy for targeting bacteria to enhance the antibacterial efficacy of current antibiotics.
Development of Nanocarrier‐Based Oral Pegfilgrastim Formulations for Mitigating Hematopoietic Acute Radiation Syndrome
Authors: Zhu Yuefei , Tavakol Daniel Naveed , Wang Huaxi , He Siyu , Ponnaiya Brian , Zhu Zixian , Xiao Yongqiang , Yoshinaga Naoto , Wu Xuefeng , Wu Xiaoyu , Ning Derek , Baldassarri Ilaria , Teles Diogo , Amundson Sally A. , Garty Guy , Brenner David J. , Vunjak‐Novakovic Gordana , Leong Kam W. 
Published: February 2025

AbstractThe increasing risks of ionizing radiation (IR) from deep space travel and nuclear accidents necessitate the development of effective countermeasures. Acute radiation syndrome (ARS), particularly hematopoietic ARS (H‐ARS), leads to life‐threatening anemia and bone marrow failure, with long‐term risks including cancer and cardiovascular disease. This study presents phenylboronic acid‐functionalized chitosan‐polyethylenimine (CPB) polymers designed for efficient oral delivery of pegfilgrastim (PF), an FDA‐approved radioprotective agent. Nanoparticles are prepared through complexation of PF with tannic acid, forming a negatively charged core, followed by encapsulation with a CPB polymer shell. This supramolecular strategy enables efficient protein condensation into uniform nanoparticles. The nanosystem effectively reduces H‐ARS‐associated anemia in mice by promoting blood cell reconstitution, supported by in vitro results with human hematopoietic stem/progenitor cells. Additionally, the material reduces toll‐like receptor activation in multiple human cell types post‐radiation. This system may mitigate radiation injury risks from accidental exposure on Earth and during extended space missions.
Lithium Carbide Prelithiation Agent‐Coated Separator Facilitates Compact Expansion of Silicon Electrode
Authors: Li Liewu , Gong Xiaoyu , Chen Chufang , Huang Zhencheng , Chen Weibin , Jiang Qianqian , Chen Jing , Wang Jionghui , He Liqing , Cheng Tengfei , Wang Hongbin , Ye Shenghua , Yang Xuming , Ren Xiangzhong , Ouyang Xiaoping , Liu Jianhong , Zhang Qianling , Hu Jiangtao 
Published: February 2025

AbstractThe high specific capacity and safety nature of silicon (Si) anode has garnered significant attention and investment for its application in high‐energy‐density lithium‐ion batteries (LIBs). However, the Si anode exhibits low initial Coulombic Efficiency (CE) and compromised cycle stability due to interfacial side reactions and the volume expansion of Si particles. Here, a straightforward strategy is proposed to prelithiate Si anodes and enhance the cycle stability by utilizing a lithium carbide (LiC6) coated separator. By incorporating a LiC6 prelithiation agent‐coated PP/PE separator (PP/PE@LiC6), a robust interaction between PP/PE@LiC6 and Si anode forms during cycling, which significantly reduces subsequent contact between the electrolyte and Si particles, thereby minimizing excessive electrolyte decomposition during cycling, and facilitates the compact expansion of the Si electrode. In Si|PP/PE@LiC6|Li cell, the initial CE reaches 108.51%, showcasing enhanced electrochemical stability (77.93% after 100 cycles). Moreover, the Si|PP/PE@LiC6|LiFePO4 cell also exhibits exceptional initial CE of ≈93.02% and improved electrochemical stability (100.94% after 100 cycles at 0.33C). This study introduces a secure and readily attainable prelithiation method for industrial applications of high‐energy density Si‐based batteries.
Self‐Generated Glass‐Ceramics‐Like Structure Boosts Energy Storage Performance of AgNbO3‐Based MLCC
Authors: Tang Ting , Liu Jiecheng , Liu Dong , Han Yi , Luan Rundong , Wang Qi , Liu Hui , Zhang Bo‐Ping , Zheng Qiang , Deng Shiqing , Zhu Yimei , Wu Lijun , Xu Juping , Yin Wen , Shi Xiaoming , Zhu Li‐Feng 
Published: February 2025

AbstractDielectric capacitors are strikingly attractive for use in advanced high‐power pulsed‐discharge devices for electronic systems. However, their poor energy‐storage density (Urec) and efficiency (η) resulting from the large remanent polarization (Pr) and low breakdown strength (BDS), have been the major challenge for practical applications. Inspired by the glass ceramics in which the core‐shell microstructure is considered an effective method to improve the BDS, maintain large Pmax, and reduce Pr values, the strategy of “self‐generated glass‐ceramics‐like structure” is proposed in this work, and the (EuxAg1−3x)NbO3 (EuxAN) at 0.00 ≤ x ≤ 0.09 capacitors are designed. Similar to glass ceramics, the ceramics‐like AFE regions in the “self‐generated glass‐ceramics‐like structure” help to improve Pmax value, while glass‐like PE regions are responsible for increasing the BDS of the capacitor, so as to achieve ultrahigh Urec and η values. Because of the glass‐ceramics‐like structure, high recoverable energy storage Urec ≈ 16.6 J cm−3 along with an excellent η ≈ 93.1% are achieved in the EuxAN (x = 0.07) multilayer capacitors. This work offers a good paradigm for improving the energy storage properties of AFE systems to meet the demanding requirements of advanced energy storage applications.
Cholesterol Functionalized Nanoparticles Are Effective against Helicobacter pylori, the Gastric Bug: A Proof‐of‐Concept Study
Authors: Pinho Ana Sofia , Pereira Renato , Pereira Mariana , Rai Akhilesh , Ferreira Lino , Martins Maria Cristina Lopes , Parreira Paula 
Published: February 2025

AbstractHelicobacter pylori chronic infection is the highest risk factor for the development of gastric cancer, being this Gram‐negative bacterium classified as carcinogenic. The mounting resistance of H. pylori to antibiotics calls for innovative therapeutic strategies. Here, the proof‐of‐concept studies that support the development of a “trojan horse” therapeutic strategy based on cholesterol‐grafted nanoparticles (Chol‐NP) to counteract H. pylori infection are depicted. The bacterium ability to specifically recognize and bind to surface grafted cholesterol is demonstrated by its adhesion to cholesterol(Chol)‐functionalized self‐assembled monolayers (SAMs) on gold substrates (2D Chol‐SAMs) in a concentration dependent manner, with optimal Chol‐SAMs prepared with 25% Chol‐polyethylene glycol (PEG)‐thiol in solution (75% tetra(ethylene glycol)‐thiol). These results further show that cholesterol functionalized gold nanoparticles (3D Chol‐SAMs, Chol‐NP) eradicate H. pylori at a minimum bactericidal concentration of 125 µg mL−1. Chol‐NP kill H. pylori through internalization and membrane rupture, as observed by transmission electron microscopy (TEM). Chol‐NP are cytocompatible (human gastric adenocarcinoma (AGS) cell line), non‐hemolytic and innocuous to bacteria representative of the gut microbiota (Escherichia coli and Lactobacillus acidophilus). This study supports the further development of cholesterol functionalized biomaterials as an advanced and targeted treatment for H. pylori infection.
Rapid, Sensitive Detection of Protein Biomarkers in Minimally‐Processed Blood Products with a Monolithic Sandwich Immunoassay Reagent
Authors: Maganzini Nicolò , Reschke Agnes , Cartwright Alyssa P. , Gidi Yasser , Thompson Ian Andrew Paul , Yee Steven , Hariri Amani , Dory Constantin , Rosenberg‐Hasson Yael , Pan Jing , Eisenstein Michael , Vučković Jelena , Cornell Timothy Thomas , Soh Hyongsok Tom 
Published: February 2025

AbstractFor more than fifty years, the enzyme‐linked immunosorbent assay (ELISA) serves as the gold standard for protein biomarker detection. However, conventional ELISA requires considerable sample preparation including reagent addition, incubation, and washing steps, limiting its usefulness at the point‐of‐care. In this work, the “instant ELISA” (fluorophore‐linked immunosorbent assay) biosensor that can measure protein biomarkers in the picomolar range within 15 min in undiluted plasma or serum with no sample preparation is described. The sensor leverages a synthetic reagent termed the “monolithic dual‐antibody clamp” (MDAC) which preserves the specificity, sensitivity, and generalizability of an ELISA, but produces a fluorescence signal as two surface‐tethered antibodies form a “sandwich” by binding to two distinct epitopes on the target. As exemplars, picomolar quantification of tumor necrosis factor alpha (TNFα) and monocyte chemotactic protein (MCP)‐1, the latter of which is a useful prognostic indicator of cytokine release syndrome in patient plasma samples during chimeric antigen receptor T cell therapy are demonstrated.
Lyotropic Liquid Crystal Mediated Assembly of Donor Polymers Enhances Efficiency and Stability of Blade‐Coated Organic Solar Cells
Authors: Khasbaatar Azzaya , Damron Alec M. , Fernando Pravini S. , Williams Jasmine S. , Zhu Chenhui , Gann Eliot H. , Lee Jong‐Hoon , Birge Adrian , Kim Bora , Sabury Sina , Lee Minjoo L. , Reynolds John R. , Diao Ying 
Published: February 2025

AbstractConjugated polymers can undergo complex, concentration‐dependent self‐assembly during solution processing, yet little is known about its impact on film morphology and device performance of organic solar cells. Herein, lyotropic liquid crystal (LLC) mediated assembly across multiple conjugated polymers is reported, which generally gives rise to improved device performance of blade‐coated non‐fullerene bulk heterojunction solar cells. Using D18 as a model system, the formation mechanism of LLC is unveiled employing solution X‐ray scattering and microscopic imaging tools: D18 first aggregates into semicrystalline nanofibers, then assemble into achiral nematic LLC which goes through symmetry breaking to yield a chiral twist‐bent LLC. The assembly pathway is driven by increasing solution concentration – a common driving force during evaporative assembly relevant to scalable manufacturing. This assembly pathway can be largely modulated by coating regimes to give 1) lyotropic liquid crystalline assembly in the evaporation regime and 2) random fiber aggregation pathway in the Landau–Levich regime. The chiral liquid crystalline assembly pathway resulted in films with crystallinity 2.63 times that of films from the random fiber aggregation pathway, significantly enhancing the T80 lifetime by 50‐fold. The generality of LLC‐mediated assembly and enhanced device performance is further validated using polythiophene and quinoxaline‐based donor polymers.
Hopping‐Phase Ion Bridge Enables Fast Li+ Transport in Functional Garnet‐Type Solid‐State Battery at Room Temperature
Authors: Yang Binbin , Chen Nan , Tian Jianing , Sun Lipu , Deng Chenglong , Shang Yanxin , Liu Zixin , Wu Ningning , Zhao Liyuan , Wu Feng , Xia Dingguo , Chen Renjie 
Published: February 2025

AbstractComposite polymer electrolytes (CPEs) containing Li6.4La3Zr1.4Ta0.6O12 (LLZTO) is widely regarded as leading candidate for high energy density solid‐state lithium‐metal batteries due to its exceptional ionic conductivity and environmental stability. However, Li2CO3 and LiOH layers at LLZTO surface greatly hinder Li+ transport between LLZTO‐polymer and the electrode–electrolyte interface. Herein, the surface of LLZTO is boronized to obtain functionalized LLZTO, and its conversion mechanism is clarified. By dissolving the crystal structure of cellulose to obtain hopping‐phase ion bridge (HPIB), which release the Li+ transport activity of its oxygen‐containing polar functional group (─OH, ─O─). Therefore, a high‐throughput ion transporter (HTIT‐37) with high ion transfer number (0.86) is prepared by introducing the HPIB into functionalized LLZTO and polyvinylidene fluoride interface by intermolecular hydrogen bond interaction, and it is demonstrated that the HPIB acts as a “highway” for the Li+ across this heterogeneous interface. Moreover, the HPIB is found to self‐adsorb on the SEI surface, leading to fast Li+ transport kinetics at anode–CPE interface. Thus, the lifespan of Li|HTIT‐37|Li is over 8000 h, and the critical current density exceeds 2.3 mA cm−2. The LiNi0.5Co0.2Mn0.3O2|Li and Li1.2Ni0.13Co0.13Mn0.54O2|Li battery remains stable with the HPIB‐enhanced electrode process, proving the application potential of LLZTO‐based CPE in high energy density SSLMB.
Engineered Living Systems Based on Gelatin: Design, Manufacturing, and Applications
Authors: Wang Zhenwu , Lin Zeng , Mei Xuan , Cai Ling , Lin Ko‐Chih , Rodríguez Jimena Flores , Ye Zixin , Parraguez Ximena Salazar , Guajardo Emilio Mireles , García Luna Pedro Cortés , Zhang Jun Yi Joey , Zhang Yu Shrike 
Published: February 2025

AbstractEngineered living systems (ELSs) represent purpose‐driven assemblies of living components, encompassing cells, biomaterials, and active agents, intricately designed to fulfill diverse biomedical applications. Gelatin and its derivatives have been used extensively in ELSs owing to their mature translational pathways, favorable biological properties, and adjustable physicochemical characteristics. This review explores the intersection of gelatin and its derivatives with fabrication techniques, offering a comprehensive examination of their synergistic potential in creating ELSs for various applications in biomedicine. It offers a deep dive into gelatin, including its structures and production, sources, processing, and properties. Additionally, the review explores various fabrication techniques employing gelatin and its derivatives, including generic fabrication techniques, microfluidics, and various 3D printing methods. Furthermore, it discusses the applications of ELSs based on gelatin in regenerative engineering as well as in cell therapies, bioadhesives, biorobots, and biosensors. Future directions and challenges in gelatin fabrication are also examined, highlighting emerging trends and potential areas for improvements and innovations. In summary, this comprehensive review underscores the significance of gelatin‐based ELSs in advancing biomedical engineering and lays the groundwork for guiding future research and developments within the field.
Ultrafast and Universal Synthetic Route for Nanostructured Transition Metal Oxides Directly Grown on Substrates
Authors: Lim Si Heon , Kim Geunwoo , Cho Sungjin , Kim Yeong Kwon , Ko Eun Bee , Choi Seon Yeon , Heo Jung A , Kim Daegun , Yoo Hocheon , Lee So‐Yeon , Kim YongJoo , Cha Pil‐Ryung , Lee Dong Yun , Lee Sunghun , Jang Byung Chul , Kim Yeonhoo , Kim Hyun Ho 
Published: February 2025

AbstractNanostructured transition metal oxides (NTMOs) have consistently piqued scientific interest for several decades due to their remarkable versatility across various fields. More recently, they have gained significant attention as materials employed for energy storage/harvesting devices as well as electronic devices. However, mass production of high‐quality NTMOs in a well‐controlled manner still remains challenging. Here, a universal, ultrafast, and solvent‐free method is presented for producing highly crystalline NTMOs directly onto target substrates. The findings reveal that the growth mechanism involves the solidification of condensed liquid‐phase TMO microdroplets onto the substrate under an oxygen‐rich ambient condition. This enables a continuous process under ambient air conditions, allowing for processing within just a few tens of seconds per sample. Finally, it is confirmed that the method can be extended to the synthesis of various NTMOs and their related compounds.