bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term outcome of endovascular treatment for indirect carotid-cavernous fistulas
Authors: Baharvahdat Humain , Qoorchi Moheb Seraj Farid , Al-Raaisi Amira , Blanc Raphael , Najafi Sajjad , Mirbolouk Mohammad Hossein , Redjem Hocine , Ebrahimnia Feizollah , Escalard Simon , Zabihyan Samira , Desilles Jean-Philipe , Mowla Ashkan , Boisseau Willian , Mazighi Mikael , Smajda Stanislas , Piotin Michel 
Published: March 2024

OBJECTIVE
Endovascular treatment (EVT) is the primary approach used to treat indirect carotid-cavernous fistulas (CCFs). In this study, the authors evaluated the immediate and long-term efficacy and safety of different endovascular techniques for indirect CCFs.

METHODS
The databases of two endovascular centers were retrospectively reviewed to collect the patients with indirect CCFs treated using endovascular techniques between 2013 and 2023. Demographics, clinical presentation, CCF features, EVT characteristics, and clinical and radiological outcomes were evaluated and analyzed. The analysis was performed to compare the clinical and radiological data between different endovascular approaches and different embolic materials.

RESULTS
Ninety-eight patients were included in the study. EVT was successful in 95 patients (96.9%). Immediate complete obliteration of the CCF was achieved in 93.9% of patients, with 98% undergoing embolization with liquid embolic agents (LEAs) and 95.6% undergoing coiling alone. Complete CCF obliteration was higher in the transvenous than in the transarterial approach (94.3% vs 75%, p = 0.010). At ≥ 6 months follow-up, complete CCF obliteration was achieved in all patients (100%). The rate of procedure-related complications was higher following LEAs than with coiling alone (32.0% vs 15.6%). New cranial nerve (CN) palsy was diagnosed in 26.0% and 2.2% after embolization with LEAs and coiling alone, respectively (p = 0.001), with complete CN palsy recovery in 78.6%. Procedure-related intracranial hemorrhage occurred in 3 patients (3.1%). Two patients experienced an ischemic stroke following Onyx migration into the internal carotid artery. Ocular symptoms improved in 93% (83/89) of the patients who were followed.

CONCLUSIONS
In this study, complete obliteration of an indirect CCF was achieved in more than 90% of patients. Despite the occurrence of some new postprocedural ocular CN palsy, ocular symptoms improved in most patients in long-term follow-up. The transvenous approach was the most effective method for treating the indirect CCF. Coiling was safer than LEAs for the embolization of the indirect CCF.
Stereotactic radiosurgery with versus without embolization for intracranial dural arteriovenous fistulas: a systematic review and meta-analysis
Authors: Maroufi Seyed Farzad , Fallahi Mohammad Sadegh , Ghasemi Moein , Sheehan Jason P. 
Published: March 2024

OBJECTIVE
Stereotactic radiosurgery (SRS) has been established as a safe and alternative treatment for dural arteriovenous fistulas (dAVFs). While embolization alone is the most commonly used modality for the treatment of dAVFs, the adjunctive use of embolization with SRS, with the growing use of SRS, has gained increasing interest in the past few years. However, the relative efficacy and safety of SRS combined with embolization versus SRS alone for dAVFs remains uncertain. Hence, this systematic review aimed to evaluate the efficacy of SRS with adjunctive embolization for intracranial dAVFs.

METHODS
A systematic review and meta-analysis was conducted by searching electronic databases, including PubMed, Embase, and the Cochrane Library, up to August 2023. All studies evaluating the utilization of adjunctive embolization and SRS for dAVFs were included. Risk of bias was assessed using the Newcastle-Ottawa Scale. A meta-analysis was conducted on the suitable outcomes.

RESULTS
Eighteen studies involving 715 patients were included. The mean age of the participants in the study was 64.30 years in the adjunctive embolization group and 60.51 years in the SRS-alone group. In the adjunctive embolization group 41.3% of patients were female, compared with 47.1% in the SRS-only group. The dAVF obliteration rates were 64.7% and 65.7% in the adjunctive embolization and SRS-alone groups, respectively. These obliteration rates were comparable between the two groups (p = 0.96), as were the symptom improvement rates (p = 0.35). Adverse events were rare, and were more commonly associated with the adjunctive embolization procedure, although further causal analysis was not possible.

CONCLUSIONS
This study provides evidence that adjunctive embolization plus SRS provides similar obliteration and symptom improvement rates compared with SRS alone, with both having very limited SRS-related adverse events. Considering the added burden and adverse events of additional endovascular treatment, the authors recommend embolization be reserved for more complex dAVFs or when embolization can potentially be curative alone or provide more rapid symptomatic relief or protection during the radiosurgical latency period.
Intracranial dural arteriovenous fistulas: association with cerebral venous thrombosis, baseline aggressiveness, and clinical outcomes. A retrospective multicenter study on 263 consecutive patients and literature review
Authors: Cohen Clara , Lenck Stéphanie , Talbi Atika , Ifergan Héloïse , Premat Kévin , Boulouis Grégoire , Janot Kévin , Boch Anne-Laure , Magni Christophe , Herbreteau Denis , Sourour Nader , Shotar Eimad , Barrot Valère , Clarençon Frédéric 
Published: March 2024

OBJECTIVE
The pathogenesis of intracranial dural arteriovenous fistulas (icDAVFs) is controversial. Cerebral vein thrombosis (CVT) and venous hypertension are recognized predisposing factors. This study aimed to evaluate the incidence of association between icDAVF and CVT and describe baseline aggressiveness and clinical outcomes for icDAVFs associated with CVT. The authors also performed a literature review of studies reporting icDAVF associated with CVT.

METHODS
Two hundred sixty-three consecutive patients in two university hospitals with confirmed icDAVFs were included. A double-blind imaging review was performed to determine the presence or absence of CVT close or distant to the icDAVF. Location, type (using the Cognard classification), aggressiveness of the icDAVF, clinical presentation, treatment modality, and clinical and/or angiographic outcomes at 6 months were also collected. All prior brain imaging was analyzed to determine the natural history of onset of the icDAVF.

RESULTS
Among the 263 included patients, 75 (28.5%) presented with a CVT concomitant to their icDAVF. For 18 (78.3%) of 23 patients with previous brain imaging available, CVT preceding the icDAVF was proven (6.8% of the overall population). Former/active smoking (OR 2.0, 95% CI 1.079–3.682, p = 0.022) and prothrombogenic status (active inflammation or cancer/coagulation trouble) were risk factors for CVT associated with icDAVF (OR 3.135, 95% CI 1.391–7.108, p = 0.003). One hundred eighty-seven patients (71.1%) had a baseline aggressive icDAVF, not linked to the presence of a CVT (p = 0.546). Of the overall population, 11 patients (4.2%) presented with spontaneous occlusion of their icDAVF at follow-up. Seven patients (2.7%) died during the follow-up period. Intracranial DAVF + CVT was not associated with a worse prognosis (modified Rankin Scale score at 3–6 months: 0 [interquartile range {IQR} 0–1] for icDAVF + CVT vs 0 [IQR 0–0] for icDAVF alone; p = 0.055).

CONCLUSIONS
This was one of the largest studies focused on the incidence of CVT associated with icDAVF. For 6.8% of the patients, a natural history of CVT leading to icDAVF was proven, corresponding to 78.3% of patients with previous imaging available. This work offers further insights into icDAVF pathophysiology, aiding in identifying high-risk CVT patients for long-term follow-up imaging. Annual imaging follow-up using noninvasive vascular imaging (CT or MR angiography) for a minimum of 3 years after the diagnosis of CVT should be considered in high-risk patients, i.e., smokers and those with prothrombogenic status.
What Threshold of Amyloid Reduction Is Necessary to Meaningfully Improve Cognitive Function in Transgenic Alzheimer’s Disease Mice?
Authors: Singh Anita , Maker Matthew , Prakash Jayant , Tandon Raghav , Mitchell Cassie S. 
Published: March 2024

Background: Amyloid-β plaques (Aβ) are associated with Alzheimer’s disease (AD). Pooled assessment of amyloid reduction in transgenic AD mice is critical for expediting anti-amyloid AD therapeutic research. Objective: The mean threshold of Aβ reduction necessary to achieve cognitive improvement was measured via pooled assessment ( n = 594 mice) of Morris water maze (MWM) escape latency of transgenic AD mice treated with substances intended to reduce Aβ via reduction of beta-secretase cleaving enzyme (BACE). Methods: Machine learning and statistical methods identified necessary amyloid reduction levels using mouse data (e.g., APP/PS1, LPS, Tg2576, 3xTg-AD, control, wild type, treated, untreated) curated from 22 published studies. Results: K-means clustering identified 4 clusters that primarily corresponded with level of Aβ: untreated transgenic AD control mice, wild type mice, and two clusters of transgenic AD mice treated with BACE inhibitors that had either an average 25% “medium reduction” of Aβ or 50% “high reduction” of Aβ compared to untreated control. A 25% Aβ reduction achieved a 28% cognitive improvement, and a 50% Aβ reduction resulted in a significant 32% improvement compared to untreated transgenic mice ( p < 0.05). Comparatively, wild type mice had a mean 41% MWM latency improvement over untreated transgenic mice ( p < 0.05). BACE reduction had a lesser impact on the ratio of Aβ42 to Aβ40. Supervised learning with an 80% –20% train-test split confirmed Aβ reduction was a key feature for predicting MWM escape latency (R2 = 0.8 to 0.95). Conclusions: Results suggest a 25% reduction in Aβ as a meaningful treatment threshold for improving transgenic AD mouse cognition.
Predictors of response in PROMIS-global in a chronic low back pain specialty clinic: STarTBack and chronic overlapping pain conditions
Authors: Zheng Patricia , Ewing Susan , Tang Angelina , Black Dennis , Hue Trisha , Lotz Jeffrey , Peterson Thomas , Torres-Espin Abel , O’Neill Conor 
Published: March 2024

BACKGROUND: Tools, such as the STarTBack Screening Tool (SBT), have been developed to identify risks of progressing to chronic disability in low back pain (LBP) patients in the primary care population. However, less is known about predictors of change in function after treatment in the specialty care population. OBJECTIVE: We pursued a retrospective observational cohort study involving LBP patients seen in a multidisciplinary specialty clinic to assess which features can predict change in function at follow-up. METHODS: The SBT was administered at initial visit, and a variety of patient characteristics were available in the chart including the presence of chronic overlapping pain conditions (COPCs). Patient Reported Outcomes Measurement Information System-10 (PROMIS-10) global physical health (PH) and global mental health (MH) were measured at baseline and at pragmatic time points during follow-up. Linear regression was used to estimate adjusted associations between available features and changes in PROMIS scores. RESULTS: 241 patients were followed for a mean of 17.0 ± 7.5 months. Mean baseline pain was 6.7 (SD 2.1), PROMIS-10 global MH score was 44.8 (SD 9.3), and PH score was 39.4 (SD 8.6). 29.7% were low-risk on the SBT, 41.8% were medium-risk, and 28.5% were high-risk. Mean change in MH and PH scores from baseline to the follow-up questionnaire were 0.86 (SD 8.11) and 2.39 (SD 7.52), respectively. Compared to low-risk patients, high-risk patients had a mean 4.35 points greater improvement in their MH score (p= 0.004) and a mean 3.54 points greater improvement in PH score (p= 0.006). Fewer COPCs also predicted greater improvement in MH and PH. CONCLUSIONS: SBT and the presence of COPC, which can be assessed at initial presentation to a specialty clinic, can predict change in PROMIS following treatment. Effort is needed to identify other factors that can help predict change in function after treatment in the specialty care setting.
T-Bipolar soft groups and their fundamental laws
Authors: Mahmood Tahir , Hussain Kashif , Ahmmad Jabbar , Shahab Sana , ur Rehman Ubaid , Anjum Mohd 
Published: March 2024

The notion of a T-bipolar soft set (T - BSftS) is the structure that has the ability to discuss the two-sided aspects of certain situations like the effects and side effects of a medicine. Moreover, T - BSftS has the ability to discuss the parametrization tool as well. Also, notice that a group is an algebraic structure that is the key tool in many branches of mathematics. In many decision-making situations, we have to discuss the two-sided aspects of a certain situation and we can see that T - BSftS is the only structure that can handle it. So based on a characteristic of T - BSftS and groups theory there is a need to define the combined notion of T - BSftS and group. So, based on these valuable structures, in this manuscript, we aim to introduce the notion of T-bipolar soft groups by generalizing T-bipolar soft sets. Based on this newly defined structure, we have defined the basic operational laws like extended union, extended intersection, restricted union, restricted intersection, AND product, and OR product for T-bipolar soft groups. Moreover, we have observed the impact of these newly defined notions on T-bipolar soft groups.
Comparison of Oncological and Functional Outcomes of Radical Versus Partial Nephrectomy for cT1b Renal Cell Carcinoma: A Two-Centre, Matched Analysis
Authors: van den Brink Luna , van den Kroonenberg Daniel L. , Graafland Niels M. , Bex Axel , Beerlage Harrie P. , van Moorselaar Jeroen R.A. , Zondervan Patricia J. 
Published: March 2024

BACKGROUND: It remains unclear which patients with cT1b renal cell carcinoma (RCC) benefit most from partial nephrectomy (PN) versus radical nephrectomy (RN) considering oncological outcomes and renal function. OBJECTIVE: To compare oncological and functional outcomes of RN with PN for cT1b RCC. METHODS: This is a retrospective analysis of patients who underwent RN or PN for cT1b between 2010 and 2022 ( n = 241). Patients were grouped by RN or PN and matched by age, sex, Charlson Comorbidity Index, BMI, PADUA score, RENAL score, ASA score, and preoperative kidney function (eGFR) using propensity score matching. The 10-year overall survival (OS), 10-year cancer-specific survival (CSS), and 10-year recurrence-free survival (RFS) were compared. Change in eGFR from baseline to 5-year follow-up was assessed. RESULTS: After matching, 100 patients remained in each group for analysis. The 10-year OS, CSS, and RFS rates were similar between groups. For patients classified as low risk, the PN group displayed a higher recurrence rate compared to RN (7 vs. 0, p = 0.01). Patients who underwent RN had worse 1-year postoperative eGFR than PN (RN: 57 [44–65], PN: 73 [60–87], p < 0.001). RN was more likely to induce new-onset chronic kidney disease (CKD) stage ≥3b compared to PN ( p < 0.001). Complication rate after PN was significantly higher ( p = 0.003). CONCLUSION: 10-year survival rates were similar, despite more recurrences in the PN group. Our data shows that post-surgical renal function is superior for PN. Nevertheless, RN is a reliable treatment option when preservation of renal function is not a priority.
Incidente de falta de personalidad en las sociedades mercantiles
Authors: Pérez Cázares Martín Eduardo 
Published: March 2024

<p>El presente trabajo es una reflexión respecto a las exigencias que se piden dentro de un procedimiento mercantil para acreditar la representación de una sociedad mercantil, que va mas allá de lo que la misma legislación mercantil señala y que aflora al momento de la interposición del incidente de falta de personalidad.</p><p> El tema refleja una importancia trascendental en materia procesal, puesto que vemos al incidente como parte de un sistema del derecho procesal mercantil, que interactúa con él.</p> Se elabora un concepto de incidente desde la perspectiva procesal, desmembrándolo para llegar a su contenido; así mismo vemos el concepto de personalidad aplicado al derecho procesal.
EL RUMBO DE LOS GOBIERNOS DE COALICIÓN EN MÉXICO
Authors: Montoya Zamora Raúl , Valles Santillán Gabriela Guadalupe , Alanís Herrera María Magdalena 
Published: March 2024

<p>En este trabajo se realizarán algunas reflexiones sobre el rumbo que pueden tomar los gobiernos de coalición en México, y se delinearán algunas ideas en las que se pueden sustentar algunas propuestas para regular de la mejor forma posible la figura de gobierno de coalición en nuestro país, al ser una novedosa inclusión de rango constitucional en el sistema político mexicano, derivado de la reforma constitucional político-electoral publicada en el Diario Oficial de la Federación el pasado 10 de febrero de 2014.</p><p> La metodología en la que se abordará la temática expuesta será la siguiente: en primer término, se realizará un planteamiento introductorio, para posteriormente detallar un breve marco teórico que permita al lector distinguir la figura de gobierno de coalición de entre diversos tipos de alianzas partidistas que pueden suscitarse en el escenario político-electoral mexicano. Una vez hecho lo anterior, se hará alusión a la regulación vigente de los gobiernos de coalición, para luego continuar con la perspectiva y retos que se consideran respecto a éstos -incluyendo su incidencia en el ámbito de los gobiernos locales, en específico el de Durango- de cara a futuros escenarios a partir de 2018, finalizando con la correspondiente formulación de propuestas y las conclusiones.</p>
PEMBERDAYAAN MASYARAKAT MELALUI POTENSI SUMBER KESEJAHTERAAN SOSIAL
Authors: Podungge Abdul Madjid , Patilima Zulyumna A , Safitri Ikraeni 
Published: March 2024

The purpose of implementing Community Service (PkM) activities in Monggupo Village is to increase the potential sources of social welfare. Community service activities involves preparation for activities and outreach using the MPA (Methodology Participatory Assessment) technique. The results of the assessment found that the number of NSWS needing social welfare services (NSWS) found that the highest number of PPKS needing social welfare services in Monggupo Village was WPSE (Women Prone to Social Economy) with a total number of 19. In addition, it was found that the most natural product in Monggupo Village was cassava which later became a practical ingredient in making modern cakes made from cassava. These practical activities can become community entrepreneurs with modern food concepts according to the times.
GAMBARAN GEJALA PADA PASIEN COVID 19 DI RUMAH SAKIT MARY CILEUNGSI TAHUN 2021
Authors: Ristian Rista , Fauji Achmad , Andaz Amzal Mortin , Astuti Puji 
Published: March 2024

Latar Belakang: COVID-19 adalah penyakit yang disebabkan oleh turunan corona virus baru, ‘CO’ diambil dari corona ‘VI’ virus dan ‘D’ disease (penyakit).
Tujuan: Tujuan Penelitian ini untuk mengetahui gambaran gejala covid yang ada di rumah sakit Mary Cileungsi tahun 2021.
Metode: Desain penelitian yang digunakan adalah deskriptif dengan pendekatan Cross Sectional dilakukan pengumpulan data menggunakan data primer melalui lembar screning yang dilakukan terhadap 53 responden. Analisis yang digunakan adalah Univariat. Data univariat ini terjadi atas gambaran gejala pasien covid 19 yang mengalami keluhan demam, batuk, sesak nafas, hilang indra penciuman, sakit tenggorokan, diare, nyeri dada, nyeri otot atau pegal-pegal..
Hasil: Hasil penelitian ini menunjukan rata-rata pasien yang dirawat di Rumah Sakit Mary mengalami gejala demam sebanyak 37 (69,8%), gejala batuk sebanyak 45 (84,9%), gejala sesak nafas sebanyak 30 (56,6%), gejala hilang indra penciuman sebanyak 34 (64,2%), gejala sakit tenggorokan sebanyak 16 (30,2%), Diare sebanyak 14 (26,4%), gejala nyeri dada 19 (35,8%).

Kesimpulan: Dari hasil survey lembar scrining yang dilakukan di Rumah Sakit Mary Cileungsi, pasien yang mengalami kasus covid-19 terkonfirmasi rata-rata mengalami gejala Demam yaitu sebanyak 37 (69,8%) pasien. Pasien yang mengalami gejala Batuk 45 (84,9%) pasien. Pasien yang mengalami gejala Sesak Nafas yaitu sebanyak 30 (56,6%) pasien. Pasien yang mengalami gejala Hilang Indra Penciuman pada kasus covid-19 terkonfirmasi yaitu sebanyak 34 (64,2%) pasien.
GAMBARAN KEBIASAAN MENCUCI TANGAN DENGAN KEJADIAN DEMAM TYPHOID DI WILAYAH KERJA PUSKESMAS CARIU KABUPATEN BOGOR TAHUN 2021
Authors: Sumiati Ayi , Fauji Achmad , Prima Ashar , Astuti Puji 
Published: March 2024

Latar Belakang: Demam thypoid adalah infeksi sistemik yang disebabkan oleh Salmonella typhi, biasanya disebabakan oleh makanan atau air yang terkontaminasi. Badan Kesehatan Dunia World Health Organization (WHO) memperkirakan jumlah kasus demam typhoid di seluruh dunia mencapai 11 – 21 juta dengan 128 – 160 ribu kematian tiap tahunnya. Mayoritas kasus terjadi di Asia Selatan / Tenggara, dan Afrika (WHO, 2018). Kejadian demam typhoid yang dilaporkan di Indonesia adalah 81,7% 100.000 penduduk (2-4 tahun), 180,3 / 100.000 (5-15 tahun) dan 51,2 / 100.000 (≥16 tahun). Data kasus typhoid di Puskesmas Cariu pada tahun 2019 Rawat Inap Berjumlah 485 orang.
Tujuan: Tujuan Penelitian ini untuk untuk mengetahui hubungan antara personal hygine dengan kejadian demam typhoid di Puskesmas Cariu.
Metode: Jenis penelitian yang digunakan metode survey analitik dengan menggunakan pendekatan cross sectional yaitu studi yang sifatnya mengambil sampel waktu, sampel perilaku, sampel kejadian pada suatu saat tertentu saja.
Hasil: Penelitian Berdasarkan hasil penelitian dan pembahasan tentang hubungan personal hygine dengan kejadian demam typhoid di wilayah kerja Puskesmas Cariu yang dilakukan terhadap 70 responden di wilayah kerja Puskesmas Cariu didapat hasil sebagai berikut Karakteristik personal hygiene, responden menunjukan baik sebanyak 38 orang (53,6%) dan buruk sebanyak 32 orang (46,4%). Tidak adanya hubungan antara kebiasaan mencuci tangan sebelum makan dengan kejadian demem tifoid di wilayah kerja Puskesmas Cariu karena nilai p-vallue 0.627, OR=1.425 (95%CI = 0.548 – 3.704). adanya hubungan antara kebiasaan mencuci tangan setelah BAB dengan kejadian demam tifoid di wilayah kerja Puskesmas Cariu Kabupaten Bogor karena nilai p-vallue 0.016, OR=3.750 (95%CI=1.383-10.169).

Kesimpulan: Lebih dari separuh responden memiliki kebiasaan mencuci tangan sebelum makan 58,6%, memiliki kebiasaan tidak mencuci tangan setalah BAB 58,6% serta memiliki kebiasaan sering jajan diluar rumah sebesar 48,6% (n=70).