bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of cardiovascular death in patients with hepatocellular carcinoma based on the Fine-Gray model
Authors: Zhang Yu-Liang , Liu Zi-Rong , Liu Zhi , Bai Yi , Chi Hao , Chen Da-Peng , Zhang Ya-Min , Cui Zi-Lin 
Published: March 2024

BACKGROUND
Hepatocellular carcinoma (HCC) is one of the most common types of cancers worldwide, ranking fifth among men and seventh among women, resulting in more than 7 million deaths annually. With the development of medical technology, the 5-year survival rate of HCC patients can be increased to 70%. However, HCC patients are often at increased risk of cardiovascular disease (CVD) death due to exposure to potentially cardiotoxic treatments compared with non-HCC patients. Moreover, CVD and cancer have become major disease burdens worldwide. Thus, further research is needed to lessen the risk of CVD death in HCC patient survivors.
AIM
To determine the independent risk factors for CVD death in HCC patients and predict cardiovascular mortality (CVM) in HCC patients.
METHODS
This study was conducted on the basis of the Surveillance, Epidemiology, and End Results database and included HCC patients with a diagnosis period from 2010 to 2015. The independent risk factors were identified using the Fine-Gray model. A nomograph was constructed to predict the CVM in HCC patients. The nomograph performance was measured using Harrell’s concordance index (C-index), calibration curve, receiver operating characteristic (ROC) curve, and area under the ROC curve (AUC) value. Moreover, the net benefit was estimated via decision curve analysis (DCA).
RESULTS
The study included 21545 HCC patients, of whom 619 died of CVD. Age (< 60) [1.981 (1.573-2.496), P < 0.001], marital status (married) [unmarried: 1.370 (1.076-1.745), P = 0.011], alpha fetoprotein (normal) [0.778 (0.640-0.946), P = 0.012], tumor size (≤ 2 cm) [(2, 5] cm: 1.420 (1.060-1.903), P = 0.019; > 5 cm: 2.090 (1.543-2.830), P < 0.001], surgery (no) [0.376 (0.297-0.476), P < 0.001], and chemotherapy(none/unknown) [0.578 (0.472-0.709), P < 0.001] were independent risk factors for CVD death in HCC patients. The discrimination and calibration of the nomograph were better. The C-index values for the training and validation sets were 0.736 and 0.665, respectively. The AUC values of the ROC curves at 2, 4, and 6 years were 0.702, 0.725, 0.740 in the training set and 0.697, 0.710, 0.744 in the validation set, respectively. The calibration curves showed that the predicted probabilities of the CVM prediction model in the training set vs the validation set were largely consistent with the actual probabilities. DCA demonstrated that the prediction model has a high net benefit.
CONCLUSION
Risk factors for CVD death in HCC patients were investigated for the first time. The nomograph served as an important reference tool for relevant clinical management decisions.
Identification of a novel inflammatory-related gene signature to evaluate the prognosis of gastric cancer patients
Authors: Hu Jia-Li , Huang Mei-Jin , Halina Halike , Qiao Kun , Wang Zhi-Yuan , Lu Jia-Jie , Yin Cheng-Liang , Gao Feng 
Published: March 2024

BACKGROUND
Gastric cancer (GC) is a highly aggressive malignancy with a heterogeneous nature, which makes prognosis prediction and treatment determination difficult. Inflammation is now recognized as one of the hallmarks of cancer and plays an important role in the aetiology and continued growth of tumours. Inflammation also affects the prognosis of GC patients. Recent reports suggest that a number of inflammatory-related biomarkers are useful for predicting tumour prognosis. However, the importance of inflammatory-related biomarkers in predicting the prognosis of GC patients is still unclear.
AIM
To investigate inflammatory-related biomarkers in predicting the prognosis of GC patients.
METHODS
In this study, the mRNA expression profiles and corresponding clinical information of GC patients were obtained from the Gene Expression Omnibus (GEO) database (GSE66229). An inflammatory-related gene prognostic signature model was constructed using the least absolute shrinkage and selection operator Cox regression model based on the GEO database. GC patients from the GSE26253 cohort were used for validation. Univariate and multivariate Cox analyses were used to determine the independent prognostic factors, and a prognostic nomogram was established. The calibration curve and the area under the curve based on receiver operating characteristic analysis were utilized to evaluate the predictive value of the nomogram. The decision curve analysis results were plotted to quantify and assess the clinical value of the nomogram. Gene set enrichment analysis was performed to explore the potential regulatory pathways involved. The relationship between tumour immune infiltration status and risk score was analysed via Tumour Immune Estimation Resource and CIBERSORT. Finally, we analysed the association between risk score and patient sensitivity to commonly used chemotherapy and targeted therapy agents.
RESULTS
A prognostic model consisting of three inflammatory-related genes (MRPS17, GUF1, and PDK4) was constructed. Independent prognostic analysis revealed that the risk score was a separate prognostic factor in GC patients. According to the risk score, GC patients were stratified into high- and low-risk groups, and patients in the high-risk group had significantly worse prognoses according to age, sex, TNM stage and Lauren type. Consensus clustering identified three subtypes of inflammation that could predict GC prognosis more accurately than traditional grading and staging. Finally, the study revealed that patients in the low-risk group were more sensitive to certain drugs than were those in the high-risk group, indicating a link between inflammation-related genes and drug sensitivity.
CONCLUSION
In conclusion, we established a novel three-gene prognostic signature that may be useful for predicting the prognosis and personalizing treatment decisions of GC patients.
Effects of Helicobacter pylori and Moluodan on the Wnt/β-catenin signaling pathway in mice with precancerous gastric cancer lesions
Authors: Wang Yi-Mei , Luo Zheng-Wei , Shu Yu-Lin , Zhou Xiu , Wang Lin-Qing , Liang Chun-Hong , Wu Chao-Qun , Li Chang-Ping 
Published: March 2024

BACKGROUND
Helicobacter pylori (H. pylori ) is the primary risk factor for gastric cancer (GC), the Wnt/β-Catenin signaling pathway is closely linked to tumourigenesis. GC has a high mortality rate and treatment cost, and there are no drugs to prevent the progression of gastric precancerous lesions to GC. Therefore, it is necessary to find a novel drug that is inexpensive and preventive to against GC.
AIM
To explore the effects of H. pylori and Moluodan on the Wnt/β-Catenin signaling pathway and precancerous lesions of GC (PLGC).
METHODS
Mice were divided into the control, N-methyl-N-nitrosourea (MNU), H. pylori + MNU, and Moluodan groups. We first created an H. pylori infection model in the H. pylori + MNU and Moluodan groups. A PLGC model was created in the remaining three groups except for the control group. Moluodan was fed to mice in the Moloudan group ad libitum. The general condition of mice were observed during the whole experiment period. Gastric tissues of mice were grossly and microscopically examined. Through quantitative real-time PCR (qRT-PCR) and Western blotting analysis, the expression of relevant genes were detected.
RESULTS
Mice in the H. pylori + MNU group showed the worst performance in general condition, gastric tissue visual and microscopic observation, followed by the MNU group, Moluodan group and the control group. QRT-PCR and Western blotting analysis were used to detect the expression of relevant genes, the results showed that the H. pylori + MNU group had the highest expression, followed by the MNU group, Moluodan group and the control group.
CONCLUSION
H. pylori can activate the Wnt/β-catenin signaling pathway, thereby facilitating the development and progression of PLGC. Moluodan suppressed the activation of the Wnt/β-catenin signaling pathway, thereby decreasing the progression of PLGC.
Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation, invasion, and migration of gastric cancer cells
Authors: Zhang Jing-Wen , Huang Ling-Yan , Li Ya-Ning , Tian Ying , Yu Jia , Wang Xiao-Fei 
Published: March 2024

BACKGROUND
The precise role of mitochondrial carrier homolog 2 (MTCH2) in promoting malignancy in gastric mucosal cells and its involvement in gastric cancer cell metastasis have not been fully elucidated.
AIM
To determine the role of MTCH2 in gastric cancer.
METHODS
We collected 65 samples of poorly differentiated gastric cancer tissue and adjacent tissues, constructed MTCH2-overexpressing and MTCH2-knockdown cell models, and evaluated the proliferation, migration, and invasion of human gastric epithelial cells (GES-1) and human gastric cancer cells (AGS) cells. The mitochondrial membrane potential (MMP), mitochondrial permeability transformation pore (mPTP) and ATP fluorescence probe were used to detect mitochondrial function. Mitochondrial function and ATP synthase protein levels were detected via Western blotting.
RESULTS
The expression of MTCH2 and ATP2A2 in gastric cancer tissues was significantly greater than that in adjacent tissues. Overexpression of MTCH2 promoted colony formation, invasion, migration, MMP expression and ATP production in GES-1 and AGS cells while upregulating ATP2A2 expression and inhibiting cell apoptosis; knockdown of MTCH2 had the opposite effect, promoting overactivation of the mPTP and promoting apoptosis.
CONCLUSION
MTCH2 can increase the malignant phenotype of GES-1 cells and promote the proliferation, invasion, and migration of gastric cancer cells by regulating mitochondrial function, providing a basis for targeted therapy for gastric cancer cells.
Improving Students' Vocabulary Mastery By Using U-Dictionary
Authors: Mustika Yeni , Dashela Tarina 
Published: March 2024

The teacher found several vocabulary problems faced by the students during teaching and learning English. The students were lack of vocabulary mastery, had difficulty in memorizing the word, sometimes missed spelling the word, and the difficulty pronouncing the words and finding the word's meaning. They were difficult to recognize the word classes such as nouns, verbs, adjectives, and adverbs effectively. For this reason, the researcher brought U-dictionary as media to improve students' vocabulary mastery. The classroom action research method with two cycles was used in this research. The subject was the second-semester students of Bina Sarana Informatika University consisting of 46 students. The observation and measurement techniques were used as the technique of collecting data. The observation checklists, field notes, interviews, and tests were used as the instruments for collecting data. The result showed that the use of U-Dictionary could help the teacher to improve the student's vocabulary mastery effectively. It served as a fun and simple way of learning activity. U-Dictionary led the students to build up their motivation and interest during the teaching and learning process.
STUDENTS’ READING COMPREHENSION IN LEGEND BY USING MAKE A MATCH
Authors: Khairunnisah  , Rezeki Purba Happy Sri , Angriani Lubis Rezzi 
Published: March 2024

The aims of the research were to find out the students’ reading comprehension in legend before using Make a Match Strategy, beside, to know the students’ difficulties in improvement reading comprehension by using Makea Match Strategy, and also to find out the students’ improvement by using Make a Match Strategy in reading comprehension at the grade VIII of SMP Negeri 1 Panyabungan. The writer applying this research with Classroom Action Research (CAR) used e-class was using Whats App. The subject of research was the grade VIII-1 students of SMP Negeri 1 Panyabungan. They were 30 students. The resulted shown students’ reading comprehension improves significantly, it shown from the resulted students’ percentage of pretest was 13,33%, cycle I was 53,33 %, and in cycle II was 90%. Make a Match Strategy can help students to improve reading Comprehension.
Efeitos da aplicação de Hidroxiapatita de Cálcio com Ácido Hialurônico em plano incorreto – Um Relato de Caso
Authors: Dias Carolina , Ferreira Cândido Brunielly , Almeida Bezerra Filgueira Vanuza 
Published: March 2024

O processo de envelhecimento é um fenômeno natural e inevitável que decorre de diferentes fatores, genéticos e ambientais. a pele sofre alterações, como, discromias, flacidez, sulcos e rugas. Na face, percebemos o remodelamento ósseo associado ao reposicionamento e perda das gorduras superficiais e profundas, alterando o contorno facial. O contexto mundial de aumento de expectativa de vida e a busca pela sociedade do que é imposto como belo e harmônico, gerou o aumento da busca por procedimentos estéticos como alternativa de trazer bem-estar e melhora da autoestima. O artigo tem o objetivo de relatar um caso de aplicação do HArmonyCaTM em plano incorreto e sua abordagem para resolução do caso, com uma combinação de procedimentos visando o bem estar da paciente.
Environmental Psychology for Design
Authors: Kopec Dak 
Published: March 2024

How does a room affect an occupant’s behavior and well-being? How does a building influence its residents’ health? Environmental Psychology for Design, 4th Edition, explores these questions with an in-depth look at psychosocial responses to the built environment. Awarded the 2006 ASID Joel Polsky Prize, the first edition served as an introduction to the discipline of environmental psychology and inspired readers to embrace its key concepts and incorporate them into their practice. This 4th edition continues to analyze the interaction between environments and human behavior and well-being, while exploring how individual differences related to age, gender, and cultural background impact that interaction. More discussions on logic formation and argumentation and how these ideas pertain to biological, psychological and sociological paradigms of thought have been incorporated. Additionally, chapters will be rearranged to allow for better content flow, and the emphasis will shift from person specific chapters to be place specific (i.e., schools for youth, long-term care facilities, and more). Ethical Consideration and Pandemic Ponderings box features are included throughout.
New to this Edition
-Chapters have been reorganized to be more location-centric (ie: schools, long-term care facilities, etc)
-Ethical Consideration and Pandemic Ponderings box features included for further discussion of timely topics
STUDIO Features Include
-Study smarter with self-quizzes featuring scored results and personalized study tips
-Review concepts with flashcards of terms and definitions
Instructor Resources
-Instructor’s Guide to help integrate the text into your classroom
-PowerPoint Slides for every chapter
Style Wise
Authors: Davis Jenny B. 
Published: March 2024

Style Wise: A Practical Guide to Becoming a Fashion Stylist, Third Edition is an essential text for turning aspiring stylists into professional stylists. The text presents fashion styling as a form of communication that can both support and challenge social norms such as beauty standards and gender roles. Full-color photos and examples from the runway reflect the fast-paced, vibrant fashion industry and cover topics including photo shoots, fashion shows, and special events. Step-by-step instructions guide readers through crucial areas like business basics, establishing a social media presence, and networking, while hands-on projects provide opportunities to develop a portfolio. Timelines, infographics, interviews, and learning activities that focus on the digital side of the fashion industry boost engagement and bring students up-to-date on careers in styling.
New to this Edition:
-New “The Go-By”, “The Pull List”, and “Talent Credits” features engage students with controversies in contemporary styling, provide biographies of top designers and brands, and give insights on how key individuals have contributed to the styling profession
-Emphasis on diversity, equity, and inclusion represents plus-sized and differently-abled models as well as style icons and moments in fashion history from various geographic, ethnic, and gender groups
-Coverage of topical issues such as gender-neutral fashion, cultural appropriation, and the effects of the Covid-19 pandemic
-New sections on color theory, fabric, and cultural and religious fashions
STUDIO Features Include:
-Study smarter with self-quizzes featuring scored results and personalized study tips
-Review concepts with flashcards of terms and definitions
-Access samples of documents, forms, and templates for all stages of planning a photo shoot including a call sheet form, supply checklist, planning calendars, and more
Instructor Resources
-An Instructor’s Guide to help incorporate this text into the classroom, including a test bank to provide options for student assessment
-PowerPoint® presentations include images from the book and provide a framework for lecture and discussion
Analisis Faktor Pengaruh Shift Kerja Terhadap Tingkat Produktivitas Kerja Pada Operator SPBU Di Banda Aceh Tahun 2022
Authors: Yuliza Sri , Arifin Vera Nazhira , Ariscasari Putri 
Published: March 2024

Productivity is an important indicator in economic activity. Productivity as leverage for national economic growth in the long run. This is one of the reasons many countries are competing to increase their productivity. Indonesia is recorded to have a low level of worker productivity within the Asian region. Increasing labor productivity can increase income so that welfare can be achieved. In addition, labor productivity is also an indicator to achieve high competitiveness. The purpose of this study was to determine the effect of work shifts, workload, work discipline, work experience, age, gender, length of service, and work environment on work productivity at gas station operators in Banda Aceh City in 2022. This research is descriptive analytic with cross sectional design. The population in this study were all gas station operators in Banda Aceh City, namely 32 people. Sample. Data collection was carried out for 6 days from 12 to 17 February 2022 using a questionnaire. Bivariate data analysis using the Logistic Regression test with the Stata 12 computer program. The results showed that the work productivity of gas station operators was more bad, namely 59.38% compared to good ones, which was 40.63%. The results of the logistic regression test showed that there was an effect of workload (p value=0.001), work discipline (p value=0.001), years of service (p value=0.03), and work environment (p value=0.008) on work productivity. Meanwhile, work shift (p value=0.34 and OR=0.5), age (p value=0.17 and 0.09), and gender (p value=0.17) did not affect work productivity.
1. ĐÁNH GIÁ TÌNH TRẠNG QUÁ TẢI SẮT TRÊN BỆNH NHÂN THALASSEMIA ĐIỀU TRỊ TẠI BỆNH VIỆN ĐA KHOA THỐNG NHẤT NĂM 2023
Authors: Anh Hồ Thị Phương , Hiền Nguyễn Thị , Luân Bùi Văn 
Published: March 2024

Thalassemia là bệnh về huyết sắc tố do giảm hoặc mất tổng hợp một hay nhiều chuỗi polypeptid trong globin của phân tử hemoglobin. Người bị bệnh và mang gen bệnh có ở tất cả các tỉnh/thành phố, ở tất cả các dân tộc trên toàn quốc. Việc khảo sát tình trạng quá tải sắt ở các bệnh nhân Thalassemia rất quan trọng, đưa ra cái nhìn toàn diện, từ đó giúp các bác sĩ điều trị thải sắt hiệu quả hơn, góp phần cải thiện tiên lượng lâu dài của bệnh nhân Thalassemia.

Mục tiêu: Đánh giá tình trạng quá tải sắt trên bệnh nhân Thalassemia điều trị tại Bệnh viện đa khoa Thống Nhất năm 2023
Phương pháp nghiên cứu: Nghiên cứu hồi cứu, tiến cứu, mô tả hàng loạt ca, tiến hành trên 77 bệnh nhân Thalassemia tại phòng khám huyết học và đơn vị huyết học lâm sàng - Khoa nội tổng hợp - BV đa khoa Thống Nhất từ tháng 01 đến 06 năm 2023.
Kết quả nghiên cứu: Thể bệnh Beta Thalassemia, Beta Thalassemia HbE và Alpha Thalassemia chiếm tỉ lệ lần lượt là 55,8%, 23,4% và 20,8%. Tình trạng quá tải sắt chiếm 84,5%, trong đó quá tải sắt mức độ nặng chiếm 16,9 % và quá tải sắt mức độ nhẹ và trung bình chiếm 67,6%. Bệnh nhân có đáp ứng với thuốc thải sắt Deferiprone sau 3 tháng điều trị với mức giảm nồng độ Ferritin huyết thanh trung vị là 68,2(-36,8 – 259,0) ng/mL. Có mối tương quan mạnh giữa Ferritin huyết thanh với Hb, coombs trực tiếp và ALT.
Kết luận: Bệnh nhân Thalassemia có quá tải sắt mức độ nặng chiếm 16,9 % và quá tải sắt mức độ nhẹ và trung bình chiếm 67,6%. Bệnh nhân có đáp ứng với thuốc thải sắt Deferiprone sau 3 tháng điều trị. Có mối tương quan mạnh giữa Ferritin huyết thanh với Hb, Coombs trực tiếp và ALT.
2. ĐỘNG HỌC PROCALCITONIN Ở BỆNH NHÂN VIÊM PHỔI DO VI KHUẨN
Authors: Tuấn Nguyễn Sĩ , Loan Đào Thị , Anh Nguyễn Thị Ngọc , Dũng Phạm Văn 
Published: March 2024

Mục tiêu: Procalcitonin (PCT) giúp giảm thời gian sử dụng kháng sinh trên các bệnh nhân bị nhiễm khuẩn, đặc biệt ở bệnh nhân nhiễm trùng huyết. Tuy nhiên, vai trò của PCT ở bệnh nhân viêm phổi do vi khuẩn đa kháng thuốc (P-MDR) chưa được nghiên cứu nhiều, đặc biệt là ở Việt Nam. Do đó, đề tài tiến hành nhằm mục tiêu xác định động học PCT ở bệnh nhân viêm phổi do vi khuẩn.
Phương pháp nghiên cứu: Trong nghiên cứu theo dõi dọc này, chúng tôi phân tích động học PCT ở 121 bệnh nhân có kết quả vi sinh và lâm sàng khẳng định viêm phổi do vi khuẩn từ 1/2023 đến 10/2023.
Kết quả: Có 65 bệnh nhân viêm phổi do vi khuẩn đa kháng thuốc và 56 bệnh nhân viêm phổi do vi khuẩn không đa kháng thuốc (P-nMDR). Năm tác nhân phổ biến nhất gây viêm phổi vi khuẩn là Klebsiella pneumoniae (32,23%), Acinetobacter baumannii (26,45%), Pseudomonas aeruginosa (22,31%), Staphylococcus aureus (8,26%) và Escherichia coli (5,79%). Nồng độ PCT trung bình ở nhóm P-MDR cao hơn ở nhóm P-nMDR. Thời gian thanh thải PCT ở nhóm P-MDR chậm 2,13 lần so với nhóm P-nMDR. Có 64,46% bệnh nhân chưa ngưng sử dụng kháng sinh tại thời điểm PCT về dưới 0,05 ng/ml.
Kết luận: Nồng độ PCT trung bình ở nhóm P-MDR cao hơn ở nhóm P-nMDR. Thời gian thanh thải PCT ở nhóm P-MDR chậm hơn so với nhóm P-nMDR. Cần tiến hành nghiên cứu thử nghiệm lâm sàng ngẫu nhiên có đối chứng tiếp nối đề tài này để theo dõi động học PCT trên các nhóm bệnh nhân như COPD, viêm phổi vi khuẩn trong năm 2024.
18. ĐIỀU TRỊ GÃY ĐẦU TRÊN XƯƠNG CÁNH TAY BẰNG NẸP VÍT VỚI ĐƯỜNG MỔ NHỎ TẠI BỆNH VIỆN HUYỆN CỦ CHI
Authors: Cường Nguyễn Mạnh , Nhật Phạm Văn , Tuấn Nguyễn Anh , Xuân Trần Chánh , Lâm Trần Đình , Tiến Đỗ Quang 
Published: March 2024

Đặt vấn đề: Gãy đầu trên xương cánh tay là gãy xương phổ biến và có nhiều phương pháp điều trị. Một trong những phương pháp gần đây được áp dụng tại Việt Nam là kết hợp xương nẹp vít với đường mổ nhỏ áp dụng kỹ thuật kết hợp xương nẹp vít xâm lấn tối thiểu Từ năm 2019, Bệnh viện huyện Củ Chi đã áp dụng kỹ thuật này điều trị cho các bệnh nhân gãy đầu trên xương cánh tay. Để tổng kết và đánh giá hiệu quả của phương pháp chúng tôi tiến hành nghiên cứu “Điều trị gãy đầu trên xương cánh tay bằng nẹp vít với đường mổ nhỏ tại bệnh viện huyện Củ Chi”.
Mục tiêu: Đánh giá kết quả phục hồi góc chỏm thân xương cánh tay, phục hồi chức năng khớp vai và mô tả các biến chứng. Đối tượng và Phương pháp nghiên cứu: Nghiên hồi cứu, mô tả loạt ca lâm sàng. Thu thập số liệu trên hồ sơ bệnh án bệnh nhân đã phẫu thuật MIPO gãy đầu trên xương cánh tay từ 12/2019 đến 02/2023 và thăm khám lâm sàng, cận lâm sàng trực tiếp trên bệnh nhân.
Kết quả: 33 bệnh nhân (23 nữ, 10 nam), 64,67 tuổi ± 14.05 (32 – 88 tuổi), phân loại AO: A2 (12 bệnh nhân), A3 (4 bệnh nhân), B1 (16 bệnh nhân), C1 (1 bệnh nhân), thời gian phục hồi chức năng (PHCN)là 26,06 tháng (6 – 44 tháng). Thời gian lành xương là 13,64 tuần (12 – 16 tuần). Góc chỏm thân xương cánh tay là 132,65° ± 5,07° (117,83° – 140,84 °), kết quả theo Paavolainen: 32/33 tốt, 1/33 trung bình. Điểm PHCN theo Constant Murley là 69,58 ±10,05, kết quả PHCN theo Boehm: 27/33 rất tốt, 3/33 tốt, 2/33 khá, 1/33 kém. Có 4/33 biến chứng gồm: 1 nhiễm trùng nông, 2 tổn thương thần kinh nách tạm thời, 1 cứng khớp vai.
Kết luận: MIPO gãy đầu trên xương cánh tay cho kết quả phục hồi góc chỏm thân xương cánh tay, phục hồi chức năng tốt, ít xảy ra các biến chứng.