bluuebunny/crossref_metadata_2025_split huggingface dataset:
Verapamil in treatment resistant depression: a role for the P‐glycoprotein transporter?
Authors: Clarke Gerard , O'Mahony Siobhain M , Cryan John F , Dinan Timothy G 
Published: February 2009

AbstractIntroductionVerapamil is a calcium channel blocker that also inhibits the P‐glycoprotein (Pgp) membrane transporter. We have found that administration of verapamil with a recognised antidepressant improves clinical outcome in previously treatment resistant cases despite the fact that verapamil does not possess inherent antidepressant activity. In this study we examined the hypothesis that the antidepressant‐like effects of verapamil are mediated through its blockade of the Pgp transporter in the blood brain barrier (BBB).MethodsFollowing pre‐treatment with verapamil (20 mg/kg) or a saline solution male Sprague Dawley rats were injected with imipramine (15 mg/kg). Two hours later, the animals were sacrificed, trunk blood collected and brain regions dissected out. High performance liquid chromatography (HPLC) was used to quantitate antidepressant drug concentrations in all samples.ResultsVerapamil pre‐treatment significantly elevated imipramine concentrations in all brain regions studied. The effect was most pronounced in the brainstem and frontal cortex where we observed in excess of a doubling in the brain region: serum ratios.ConclusionOur results verify inhibition of Pgp as a potential mechanism of action for verapamil during treatment resistant depression. The implications of these findings are discussed in the context of novel treatment strategies in depression. Copyright © 2009 John Wiley & Sons, Ltd.
Parental depression, parenting behaviours, and behaviour problems in young children
Authors: Middleton Melissa , Scott Samantha L. , Renk Kimberly 
Published: February 2009

AbstractIn the past, research has demonstrated that parental depression and parenting practices are related. More recently, there has been an increase in research examining child outcomes as they are related to maternal and paternal psychopathology. To continue with this line of research, this study examined the relationships among mothers' and fathers' symptoms of depression, characteristics of their parenting practices, and their ratings of their young children's internalizing and externalizing behaviour problems. The results of this study demonstrated that these variables are related significantly. Further, the results of this study suggested that mothers' parenting, particularly their limit setting with their young children, is an important predictor of their ratings of their young children's externalizing behaviour problems in the context of their own symptoms of depression. A different pattern of relationships may be present for fathers, as both their symptoms of depression and their parenting characteristics predicted their ratings of their young children's externalizing behaviour problems. Such findings were not supported for young children's internalizing behaviour problems. These findings suggested that interventions should have different targets for mothers and fathers. Copyright © 2009 John Wiley & Sons, Ltd.
Biofunctionalization of dispense‐plotted hydroxyapatite scaffolds with peptides: Quantification and cellular response
Authors: Detsch Rainer , Dieser Irina , Deisinger Ulrike , Uhl Franziska , Hamisch Sabine , Ziegler Günter , Lipps Georg 
Published: February 2009

AbstractHydroxyapatite (HA) ceramic is a widely used synthetic bone substitute material for the regeneration of bone defects. We manufactured HA scaffolds with adjustable pore sizes and pore geometry by dispense‐plotting. In addition, we attached peptides covalently onto the HA surface and are able to simultaneously quantify the amount of covalently attached and adsorbed peptide down to the picomolar range with a novel fluorescence‐based detection method. In cell culture assays with stromal bone marrow cells, we observed a positive effect of biofunctionalization on cell differentiation after 21 days of culture when comparing the scaffold functionalized with the RGD motif containing adhesion peptide to an unmodified scaffold. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
Assessment of poly(methacrylic acid‐co‐N‐vinyl pyrrolidone) as a carrier for the oral delivery of therapeutic proteins using Caco‐2 and HT29‐MTX cell lines
Authors: Carr Daniel A. , Peppas Nicholas A. 
Published: February 2009

AbstractHydrogels of poly(methacrylic acid‐co‐N‐vinyl pyrrolidone) were synthesized and evaluated for their use as carriers for oral protein delivery. Insulin loading efficiencies were determined to be near 90% for carriers crosslinked with ethylene glycol dimethacrylate with corresponding weight incorporation levels near 12%. Although no insulin was released in gastric conditions, as desired, near instantaneous release occurred when the pH was raised to values typical of the intestinal area. Cytocompatibility studies with Caco‐2 and Caco‐2/HT29‐MTX cultures demonstrated that microparticles did not elicit toxic effects at concentrations up to 5.0 mg/mL. Insulin transport studies revealed that the carriers did not disrupt the cell layer and thus did not change the insulin permeability in the apical‐to‐basolateral direction. Therefore, microparticles of this system were best suited for oral delivery of therapeutic agents that do not require transport facilitation. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
Effect of the sterilization method on the performance of collagen type I on chronic wound parameters in vitro
Authors: Wiegand Cornelia , Abel Martin , Ruth Peter , Wilhelms Tim , Schulze Daniel , Norgauer Johannes , Hipler Uta‐Christina 
Published: February 2009

AbstractIn the treatment of chronic wounds, it is necessary to establish a physiological wound milieu to improve healing. Application of collagen as wound dressing has been described as beneficial as it possesses the ability to reduce elevated levels of proteases, cytokines, and free radicals. Consequently, a wide range of wound dressings based on collagen have been developed. Native collagen is susceptible to alterations because of influences during the production process; to minimize effects on the molecule itself collagen wound dressings are usually aseptically produced. Common sterilization methods (autoclaving, irradiation, and ethylene oxide (EtO) treatment) can induce changes in the protein chemistry and physical properties, potentially affecting the absorption rate, mechanical strength, or performance. In this study, we have evaluated the influence of γ‐ and β‐irradiation as well as EtO sterilization on the binding capacity of collagen type I for selected proteases and cytokines associated with nonhealing wounds. Although a pronounced effect on the physical properties of the collagen was found, there was no significant loss in the binding affinity for polymorphonuclear elastase, matrix metalloproteinase‐2, and interleukin‐1β, or in the antioxidant capacity. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
2H‐Pyran‐2‐one‐3‐carbothioamide derivatives: Synthesis and reaction with hydrazine hydrate
Authors: Makhloufi‐Chebli Malika , Hamdi Maamar , Silva Artur M. S. , Duval Olivier , Helesbeux Jean‐Jacques 
Published: February 2009

Abstract
magnified imageN‐Aryl‐4‐hydroxy‐6‐methyl‐2H‐pyran‐2‐one‐3‐carbothiamides and N‐aryl‐4‐hydroxycoumarin‐3‐carbothiamides were synthesized by the reaction of arylisothiocyanates with 4‐hydroxy‐6‐methylpyran‐2‐one and 4‐hydroxycoumarin, respectively. Novel products 3‐[bis(arylamino)methylene]‐6‐methyl‐2H,4H‐pyran‐2,4‐diones and N,N′‐diaryl‐4‐hydroxycoumarin‐3‐carboximidamides have also been obtained in the same reactions. Novel 4‐acetoacetyl‐3‐phenylamino‐4,5‐dihydro‐5H‐pyrazol‐5‐ones were synthesized from the reaction of N‐aryl‐4‐hydroxy‐6‐methyl‐2H‐pyran‐2‐one‐3‐carbothiamides with an excess of hydrazine. The structure of all compounds was established by NMR and mass spectra. J. Heterocyclic Chem., (2009).
Synthesis of new 1‐(2‐, 3‐, or 4‐methanesulfonylphenyl)‐2‐[5‐(N‐hydroxypyridin‐2(1H)‐one)]acetylene regioisomers: A search for novel cyclooxygenase and lipoxygenase inhibitors
Authors: Chowdhury Morshed A. , Chen Hua , Abdellatif Khaled R. A. , Dong Ying , Petruk Kenneth C. , Knaus Edward E. 
Published: February 2009

Abstract
magnified imageA group of acetylene regioisomers were designed such that a cyclooxygenase‐2 (COX‐2) SO2Me pharmacophore was located at the ortho‐, meta‐, or para‐position of the acetylene C‐1 phenyl ring, and an iron‐chelating 5‐lipoxygenase (5‐LOX) N‐hydroxypyridin‐2(1H)‐one moiety was attached via its C‐5 position to the C‐2 position on an acetylene template (scaffold). These target linear acetylene regioisomers were synthesized via a palladium‐catalyzed Sonogashira cross‐coupling reaction. Structure‐activity data acquired using in vitro cell‐based inhibition assays indicated that this novel class of 1‐(2‐, 3‐, or 4‐methanesulfonylphenyl)‐2‐[5‐(N‐hydroxypyridin‐2(1H)‐one)]acetylene regioisomers did not inhibit the COX‐2 or (5‐LOX) enzymes, and that they are devoid of in vivo anti‐inflammatory activities. J. Heterocyclic Chem., 46, 58 (2009).
A new route to allyl thiols and allyl thiocarbamates from Baylis‐Hillman adducts
Authors: Kim Young‐Gi , Lim Hee Nam , Lee Kee‐Jung 
Published: February 2009

Abstract
magnified imageA facile synthesis of trisubstituted allyl thiols and allyl thiocarbamates has been accomplished from Baylis‐Hillman adducts through bromination, thiocyanation, and acid‐assisted hydrolysis reaction. J. Heterocyclic Chem., (2009)
Regioselective unusual formation of spirocyclic 4‐{3′‐benzo(2′,3′‐dihydro)furo}‐9‐methyl‐2,3,9‐trihydrothiopyrano [2,3‐b]indole by acid‐catalyzed reaction of enol ethers
Authors: Majumdar K. C. , Alam S. , Chattopadhyay B. 
Published: February 2009

Abstract
magnified imageSpirocyclic 4‐{3′‐benzo(2′,3′‐dihydro)furo}‐9‐methyl‐2,3,9‐trihydrothiopyrano[2,3‐b]indoles are regioselectively synthesized by treating suitable enol ethers, 4‐aryloxymethylene‐9‐methyl‐2,3,9‐trihydrothio‐pyrano[2,3‐b]indoles with H2SO4 in dichloromethane‐methanol‐water. The substrates for the aforesaid reaction are in turn synthesized by the thio‐Claisen rearrangement of 2‐(4′‐aryloxybut‐2′‐ynylthio)‐1‐methylindoles. J. Heterocyclic Chem., 46, 62 (2009).
Gene expression of transforming growth factor‐β1 and hepatocyte growth factor during wound healing of injured rat vocal fold
Authors: Ohno Tsunehisa , Hirano Shigeru , Rousseau Bernard 
Published: February 2009

AbstractObjectives/Hypothesis:To investigate the expression of genes coding transforming growth factor (TGF)‐β1, hepatocyte growth factor (HGF), and c‐Met, its membrane‐spanning tyrosine kinase receptor, during the inflammatory, proliferative, and remodeling phases of wound healing in the injured rat vocal fold.Study Design:Prospective animal study.Methods:Thirty five rats were involved in this study. Bilateral vocal fold wounds were created in 30 rats. Injured vocal fold specimens were harvested on postinjury day 1, 3, 7, 14, 28, and 56. Real‐time polymerase chain reaction (PCR) was used to quantify mRNA expression of TGF‐β1, HGF, and c‐Met. Five uninjured rats were used to establish PCR control.Results:Results of analysis of variance revealed a significant main effect for TGF‐β1 (P = .000), HGF (P = .000), and c‐Met (P = .000) expression across time points. Post‐hoc testing revealed that TGF‐β1 expression increased significantly on postinjury day 7 (P = .001) compared to control. HGF expression decreased significantly on postinjury day 1 (P = .001), and increased significantly on postinjury day 14 (P = .000). c‐Met expression decreased significantly on postinjury day 1 (P = .000), day 3 (P = .000), and day 56 (P = .000), and increased significantly on postinjury day 28 (P = .000).Conclusions:Results revealed time‐dependent changes in the regulation of genes coding TGF‐β1, HGF, and c‐Met during wound healing in the injured rat vocal fold. These patterns of gene expression correspond well with previously reported histologic changes of the rat vocal fold after injury. Laryngoscope, 2009
Adjustment of wear particle size distribution . of DLC coatings for tribological metal‐on‐metal pairing in artificial hip joints
Authors: Stamm B. , Küzün B. , Filipov O. , Reuter S. , Erdmann I. , Deuerler F. , Krix D. , Huba K. , Nienhaus H. , Buck V. 
Published: February 2009

AbstractThe term DLC (diamond‐like carbon) describes a whole class of different biocompatible materials based on amorphous carbon. One possible application for DLC is the coating of artificial hip joints to increase their life expectancy. The life expectancy of artificial hip joints is limited by osteolysis caused by wear particles, especially by wear particles in a range from 0.3 μm to 10 μm. In this study, biocompatible steel substrates are coated with DLC. Coatings with different structure are produced and investigated regarding their wear behavior. The aim is to influence the wear particle size distribution. To improve the adhesion of the coatings on the substrate, metallic interface layers are deposited by cathodic vacuum arc deposition, comparing chromium and titanium as interface layer material. The DLC‐coatings are deposited by a vacuum arc that allows a transition from cathodic to anodic operation mode.It is shown, that by varying the deposition process parameters and thus by variation of the film properties, the wear particle size distribution can be adjusted significantly.
Production of biohybrid protein/PEO scaffolds by electrospinning
Authors: Szentivanyi A. , Assmann U. , Schuster R. , Glasmacher B. 
Published: February 2009

AbstractElectrospun polymeric micro‐ and nanofibers offer the opportunity to reproduce the filamentous structure of the extracellular matrix in native tissues. The ability to electrospin extracellular matrix proteins offers the additional benefit of being able to create a chemical and structural microenvironment for cells in order to influence their behavior during scaffold seeding and tissue formation. This offers significant advantages over unspecific protein adsorption or functionalisation with adhesion promoting peptide sequences. However, producing electrospun fibers from pure protein solutions remains difficult and costly. A more accessible approach is to introduce proteins into electrospun fibers by blending synthetic polymer solutions with selected extracellular matrix proteins. The correct choice of polymer also makes the usage of toxic and denaturing solvents unnecessary. In this study we have investigated the production process for and the suitability of protein/PEO fibers, specifically collagen I/PEO, as cell culture substrates.
Ceramic‐on‐ceramic vs. metal‐on‐metal in total hip arthroplasty (THA): do 36‐mm diameters exhibit comparable wear performance? Keramik‐Keramik vs. Metall‐Metall in Totalprothesen‐Hüftgelenkspfanne‐. Arthroplastik: zeigen 36‐mm Durchmesser ähnliche Verschleißverhalten?
Authors: Spinelli M. , Affatato S. , Corvi A. , Viceconti M. 
Published: February 2009

AbstractHard‐on‐hard hip implants were thought as a solution to wear problems affecting polyethylene. Alumina ceramic and metal articulations are harder, biocompatible, and result in reduced wear and particles to the surrounding tissue. Alumina ceramic hip implants produce lower wear rates than other combinations (i.e. metal‐on‐metal and metal/ceramic‐on‐polyethylene) . However, ceramic presents some limitations: a higher fracture rate in the case of alumina components and hydrothermal degradation for zirconia. On the other end, metal‐on‐metal articulations have shown in vivo metal ions release and a substantial lymphocytic immune response. The wear of hard‐on‐hard bearings is affected by various design parameters, such as clearance, surface roughness, and diameter. Last generation large‐diameter metal THA designs proved effective wear performance, in in vitro testing, reducing ions release. Moreover such bearing material would prove a cost‐effective solution to ceramic designs. Aim of this study was to investigate the wear behaviour of a 36‐mm last generation metal‐on‐metal hip prosthesis and compare it to currently used 36‐mm ceramic‐on‐ceramic articulations. Wear test was carried out applying an internal protocol based on the current normative. Bovine calf serum was used as lubricant. The weight loss during the whole wear test was lower for the ceramic‐on‐ceramic combination than for the metal‐on‐metal one. Significant statistical differences were observed between the two different configurations tested.Our data favoured ceramic‐on‐ceramic combination rather than metal‐on‐metal; the total weight loss shows lower values if compared to classic metal‐on‐polyethylene bearings. It would be very useful to have a significant indicator of wear according to the other influencing design parameters (Cd, Ra, λratio) as to provide more effective design in THA. Nevertheless, a hard‐on‐hard hybrid coupling could be an interesting solution for the clinical practice, and further studies are needed.
Preparation and properties of ultra‐hydrophilic surfaces on titanium and steel
Authors: Lattner D. , Jennissen H. P. 
Published: February 2009

AbstractThe kinetics of development of ultra‐hydrophilicity by concentrated chromosulfuric acid action at 240 °C on titanium and medicinal 316L steel miniplates have been measured by a temperature‐jump method. It is shown here that ultra‐hydrophilicity (contact angle <10 °, absent contact angle hysteresis) is fully developed on electropolished titanium, anodically oxidized titanium, microstructured (sandblasted, acid etched) titanium and steel after 10–20 min in chromosulfuric acid. The simultaneous determination of the microscopic roughness factor leads to the conclusion that ultra‐hydrophilicity is not due to an increase in roughness factor, but is probably due to surface chemical changes. The very low contact angles therefore reflect high surface energies. In the case of the microstructured (sandblasted, acid etched) titanium surface the formation of a nanostructure (spheroids ca. 100 nm in diameter) especially in the valleys of the microstructure can be demonstrated. Ultra‐hydrophilicity is lost in pure water but is conserved in liquids such as dry methanol or dry ethanol and also in the dry state through protection by a fine dissication layer. Thus the titanium surface enhanced by chromsulfuric acid action displays novel physicochemical and probably biological functions in the form of ultra‐hydrophilicity and osteophilicity respectively.
Information behavior in developing countries: Research, issues, and emerging trends
Authors: Bilal Dania , Britz Johannes , Mehra Bharat , Rioux Kevin , Meho Lokman , Menou Michel 
Published: February 2009

AbstractThe field of library and information science (LIS) has historically been a leading discipline in studying human information behavior (Spink & Cole, 2006). Information seeking in industrialized nations is grounded in theories and moving towards new directions and evolutionary approaches that often challenge the established paradigms of information behavior studies (see Case, 2007; Spink & Cole, 2006; Fisher, Erdelez, & Mckechnie, 2005; Chelton & Cool, 2004. Information behavior has been conceptualized in a holistic context that draws upon theories from various disciplines such as cognitive science, communication, psychology, and computer science (Nahl & Bilal, 2007; Spink & Cole, 2006). Compared to industrialized nations, most developing countries relegate towards the bottom heap of research on information behavior (Coleman, 2005; Britz, 2005).A panel of researchers, educators, and consultants will address research in information behavior in various contexts in developing countries, particularly in India, South Africa, and the Arab world. Based on their research findings and experiences, the speakers will trace themes, map the intellectual terrain, identify emerging trends and approaches, and frame issues related to information behavior research in these countries. Moreover, they will identify significant knowledge domains, concepts, and topics of application in information behavior research where there can be mutual exchange between developing countries and the industrialized nations (including the United States) to nurture and further growth in this area of study.
What crossword puzzles teach us about information
Authors: Efron Miles 
Published: February 2009

AbstractThis paper studies crossword puzzles as a vehicle for analyzing information in a rigorous yet meaningful fashion. The paper asks, how does information operate in the context of crossword puzzles? A model is proposed that quantifies the difficulty of a puzzle P with respect to its clues. Given a clue‐answer pair (c,a), we model the difficulty of guessing a based on c using the conditional probability Pr(a | c); easier mappings should enjoy a higher conditional probability. The model is tested on a corpus of puzzles taken from The New York Times. Additionally, we discuss how the notion of information implicit in our model relates to more easily quantifiable types of information that figure into crossword puzzles.
CommNets 2.0: Using an evolutionary perspective to examine a statewide community networking initiative
Authors: Clodfelter Kathryn , Buente Wayne , Rosenbaum Howard 
Published: February 2009

AbstractIn this paper, we demonstrate how Aldrich and Ruef's (2006) community evolutionary perspective can help explain preliminary data from a follow‐up website content analysis of Indiana's community networking initiative (Clodfelter, Buente, & Rosenbaum, 2006) and provide insight into the future of community networks in a Web 2.0 environment. We start by defining community networks and introduce several time‐based views of community technology initiatives. We then describe the community evolutionary perspective and propose viewing community networks as an organizational community that is subject to the evolutionary processes of variation, selection, retention, and struggle. We then apply the community evolutionary perspective to community networking activity in the United States.
Toward an integrated framework of information and communication behavior: College students' information resources and media selection
Authors: Young Rieh Soo 
Published: February 2009

AbstractThis study investigated college students' selection of information resources and engagement in information activities from the perspective of an integrated framework of information and communication behavior, by examining students' interactions with many different types of information resources and media across their school, personal, entertainment, problem solving, and other daily routines. Both web‐based diaries and semi‐structured interviews were used to capture students' information behavior in natural settings. The subjects logged into a web‐based diary and recorded the details of their most important information seeking activity on that day by responding to eleven questions including information seeking topic, resources used, time taken, difficulty, familiarity, and confidence. Two hundred and forty‐five information seeking episodes reported by twenty‐four subjects from three different colleges and universities were collected over a ten‐day period. Findings indicate that the students used multiple information resources in one information seeking episode to verify the content in, often, both information and communication behaviors. The results also reveal that information seeking can be better understood from a social framework because students were aware that human information behavior is influenced by other people's opinions and recommendations and may also affect other people's lives.