bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilateral thoracotomy for horseshoe lung complicated with severe aspergilloma: a case report
Authors: Kagohashi Chihiro , Kurihara Yasuyuki , Hanafusa Mariko , Okubo Kenichi 
Published: April 2024

Abstract
Background
Horseshoe lung is a rare congenital malformation in which the lung protrudes from the mediastinum to the other side. Owing to the high frequency of other fatal cardiovascular complications, it is often diagnosed in childhood and rarely unnoted until adulthood. We report a case of horseshoe lung in an older patient who underwent thoracotomy.

Case presentation
The patient was a 69-year-old man with chronic obstructive pulmonary disease (COPD) and a history of heavy smoking. The patient was admitted to the hospital because of acute exacerbation of COPD. Computed tomography revealed horseshoe lung and pulmonary sequestration with pneumonia. This was the first time that he was diagnosed with horseshoe lung; however, he had been treated for pneumonia multiple times before. Surgery for the horseshoe lung was recommended; however, the patient declined it because his symptoms of acute COPD exacerbation were relieved by medication. Aspergillus infection of the horseshoe lung led to frequent bloody sputum, and the patient’s respiratory condition gradually worsened. Two years after the initial diagnosis, the patient decided to undergo the surgery. Surgery was performed in the order of left and right thoracotomies, with posterolateral thoracotomies performed bilaterally. Surgery was difficult because of strong adhesions around the inflamed lung; however, the lung was removed in one lump. The patient was extubated on postoperative day (POD) 1, and rehabilitation was initiated. His high sputum volume caused postoperative pneumonia, and the patient was again placed on a ventilator on POD 9. He underwent open-window surgery for concomitant pyothorax. The patient was weaned off the ventilator when the inflammation improved and was discharged on POD 133. The patient lived at home, developed severe pneumonia 4 months later, and died of respiratory failure.

Conclusion
Pulmonary sequestration and horseshoe lungs are congenital malformations that require surgery. The selection of the optimal time for surgery is important.
Evaluating photodynamic therapy versus brolucizumab as a second-line treatment for polypoidal choroidal vasculopathy
Authors: Funatsu Ryoh , Terasaki Hiroto , Mihara Naohisa , Sonoda Shozo , Shiihara Hideki , Sakamoto Taiji 
Published: April 2024

Abstract
Background
To compare the one-year outcomes between intravitreal brolucizumab (IVBr) monotherapy and photodynamic therapy (PDT) as a second-line treatment in patients with polypoidal choroidal vasculopathy (PCV) who did not respond to first-line therapy.

Methods
This case–control study included eyes with PCV that do not respond to aflibercept or ranibizumab. The patients were retrospectively registered. We compared outcomes, including best-corrected visual acuity (BCVA), anatomical results, and the need for additional treatments, between IVBr and a combination therapy using PDT as second-line treatments for refractory PCV, after adjusting for potential confounders. We analyzed E-values to evaluate the robustness of the results against unmeasured confounders.

Results
Twenty-two eyes received IVBr, and twenty-four underwent PDT. No apparent differences were observed in BCVA and central macular thickness (CMT) changes from baseline between the groups (IVBr vs. PDT: BCVA, 0.01 ± 0.47 logMAR vs. 0.04 ± 0.18 logMAR, P-value = 0.756; CMT: − 36.3 ± 99.4 μm vs. − 114.7 ± 181.4 μm, P-value = 0.146). Only in the PDT group, five eyes (20.8%) did not require additional treatment after the second-line treatment, the adjusted odds ratio indicating no further treatment needed was 11.98 (95% confidence interval: 1.42–2070.07, P-value = 0.019). The E-value for the adjusted odds ratio was 23.44.

Conclusions
Both second-line treatments for PCV exhibited similar visual and anatomical outcomes. Only in the PDT-treated eyes were there some patients who did not require further treatment after second-line therapy.
The overlap of accessory virulence factors and multidrug resistance among clinical and surveillance Klebsiella pneumoniae isolates from a neonatal intensive care unit in Nepal: a single-centre experience in a resource-limited setting
Authors: Shrestha Raj Kumar , Shrestha Dhruba , Kunwar Ajaya Jang , Thapa Sandeep , Shrestha Nipun , Dhoubhadel Bhim Gopal , Parry Christopher M. 
Published: April 2024

Abstract
Background
There is a lack of data on the characteristics of overlap between acquired antimicrobial resistance and virulence factors in Klebsiella pneumoniae in high-risk settings, especially with the inclusion of surveillance isolates along with the clinical. We investigated K. pneumoniae isolates, from a neonatal intensive care unit (NICU) in Nepal, for the presence of both accessory virulence factors and acquired antimicrobial resistance.

Methods
Thirty-eight clinical and nineteen surveillance K. pneumoniae isolates obtained between January 2017 and August 2022 in the NICU of Siddhi Memorial Hospital, Bhaktapur, Nepal were investigated with antimicrobial susceptibility testing, PCR-based detection of β-lactamases and virulence factors, and genetic similarity by ERIC–PCR.

Results
K. pneumoniae was found positive in 37/85 (43.5%) blood culture-positive neonatal bloodstream infections, 34/954 (3.6%) patient surveillance cultures, and 15/451 (3.3%) environmental surveillance samples. Among 57 isolates analyzed in this study, we detected multidrug resistance in 37/57 (64.9%), which was combined with at least one accessory virulence factor in 21/37 (56.8%). This overlap was mostly among β-lactamase producing isolates with accessory mechanisms of iron acquisition. These isolates displayed heterogenous ERIC–PCR patterns suggesting genetic diversity.

Conclusions
The clinical significance of this overlap between acquired antimicrobial resistance and accessory virulence genes in K. pneumoniae needs further investigation. Better resource allocation is necessary to strengthen infection prevention and control interventions in resource-limited settings.
An intelligent heating system based on the Internet of Things and STM32 microcontroller
Authors: Su Yan 
Published: April 2024

AbstractUnder the rapid growth of Internet of Things technology, many households are moving towards smart solutions. Addressing the inflexibility of temperature control in traditional heating systems, this research focuses on designing an intelligent heating system. To enhance flexibility and intelligence, an intelligent heating system based on the Internet of Things and STM32 microcontroller is proposed. Furthermore, the study identifies limitations of traditional proportional-integral-derivative control methods and establishes an optimization control model for heating system output temperature based on the Dynamic Matrix Control algorithm. Results indicate that the system's web interface successfully draws temperature curves, displaying clear data on detected temperature and humidity. The output temperature optimization control model shows a temperature rise of 2 °C and a temperature control error index of 0.0543 during the initial heating stage, and a control error index of 0.0353 during the mid-heating stage when the valve relative opening is close to 0. And the temperature control effect is better than traditional PID control, fuzzy PID control, genetic algorithm based PID control, and predictive feedback predictive control, without obvious indoor temperature overshoot phenomenon, which has certain advantages. In conclusion, the proposed system and model exhibit favorable application outcomes, offering technological support for the intelligent management of heating systems.
A comparative study in left-sided breast cancer treated with moderate deep inspiratory breath hold versus free breathing
Authors: Muraleedharan Anupam , Barik Sandip Kumar , Das Deepak Kumar , Das Majumdar Saroj Kumar , Mahapatra Bikash Ranjan , Barik Bijay Kumar , Ramasubbu Mathan Kumar , M. Nehla Haroon K. , U. Poornima Devi , Ahmed Sk Soel , Mukherjee Priyanka , Pattanaik Ashutosh , Badajena Avinash , Mishra Minakshi , Kanungo Satyabrata , Dhar Sovan Sarang , Parida Dillip Kumar 
Published: April 2024

Abstract
Background
The moderate deep inspiratory breath hold (mDIBH) is a modality famed for cardiac sparing. Prospective studies based on this are few from the eastern part of the world and India. We intend to compare the dosimetry between mDIBH and free-breathing (FB) plans.

Methods
Thirty-two locally advanced left breast cancer patients were taken up for the study. All patients received a dose of 50 Gy in 25 fractions to the chest wall/intact breast, followed by a 10-Gy boost to the lumpectomy cavity in the case of breast conservation surgery. All the patients were treated in mDIBH using active breath coordinator (ABC). The data from the two dose volume histograms were compared regarding plan quality and the doses received by the organs at risk. Paired t-test was used for data analysis.

Results
The dose received by the heart in terms of V5, V10, and V30 (4.55% vs 8.39%) and mean dose (4.73 Gy vs 6.74 Gy) were statistically significant in the ABC group than that in the FB group (all p-values < 0.001). Also, the dose received by the LADA in terms of V30 (19.32% vs 24.87%) and mean dose (32.99 Gy vs 46.65 Gy) were significantly less in the ABC group. The mean treatment time for the ABC group was 20 min, while that for the free-breathing group was 10 min.

Conclusions
Incorporating ABC-mDIBH for left-sided breast cancer radiotherapy significantly reduces the doses received by the heart, LADA, and left and right lung, with no compromise in plan quality but with an increase in treatment time.
Global perspectives on bipolar disorder treatment: in-depth comparative analysis of international guidelines for medication selection
Authors: Park Ji Hyun , Fernando Kaveesha , Park Youngja Hwang , Park Esther O. 
Published: April 2024

BackgroundBipolar disorder, a chronic mental health condition characterised by fluctuations in mood, energy and functionality, affects millions of individuals worldwide. Its management requires a comprehensive approach, and, as such, treatment guidelines have a pivotal role in guiding clinicians to alleviate symptoms, prevent relapse and enhance overall patient well-being. However, the treatment landscape is far from homogenous, with significant variations existing across different countries.AimsThis study aimed to explore and compare treatment guidelines for bipolar disorder in various regions, shedding light on the factors that influence therapeutic approaches and thus offering insights that could contribute to the ongoing refinement of evidence-based practices in management.MethodThe study explores various international treatment guidelines for bipolar disorder that have been updated after 2014. Guidelines from the UK, Canada, Australia/New Zealand, South Korea and the International College of Neuropsychopharmacology are scrutinised to identify factors contributing to the observed differences among them.ResultsThe variations in recommended drugs across guidelines arise from the approaches employed in guideline development – whether relying on expert consensus or meta-analysis results. Timing disparities in conducting these analyses and the selection of studies also exert influence. Moreover, differences in metabolic enzymes among diverse races and the health policies implemented by individual nations play a significant part in shaping these differences.ConclusionThe primary hindrance to consistent treatment conclusions lies in the scarcity of high-quality research results, leading to variations in guidelines. Enhancing evidence-based recommendations necessitates the undertaking of large-scale studies dedicated to assessing treatments for bipolar disorder.
The effects of muscle starting length on work loop power output of isolated mouse soleus and extensor digitorum longus muscle
Authors: Shelley Sharn P. , James Rob S. , Tallis Jason 
Published: April 2024

ABSTRACT
Force–length relationships derived from isometric activations may not directly apply to muscle force production during dynamic contractions. As such, different muscle starting lengths between isometric and dynamic conditions could be required to achieve maximal force and power. Therefore, this study examined the effects of starting length [±5–10% of length corresponding to maximal twitch force (L0)] on work loop (WL) power output (PO), across a range of cycle frequencies, of the soleus (SOL) and extensor digitorum longus muscle (EDL; N=8–10) isolated from ∼8 week old C57 mice. Furthermore, passive work was examined at a fixed cycle frequency to determine the association of passive work and active net work. Starting length affected maximal WL PO of the SOL and EDL across evaluated cycle frequencies (P&lt;0.030, ηp2&gt;0.494). For the SOL, PO produced at −5% L0 was greater than that at most starting lengths (P&lt;0.015, Cohen's d&gt;0.6), except −10% L0 (P=0.135, d&lt;0.4). However, PO produced at −10% L0 versus L0 did not differ (P=0.138, d=0.35-0.49), indicating −5% L0 is optimal for maximal SOL WL PO. For the EDL, WL PO produced at −10% L0 was lower than that at most starting lengths (P&lt;0.032, d&gt;1.08), except versus −5% L0 (P=0.124, d&lt;0.97). PO produced at other starting lengths did not differ (P&gt;0.163, d&lt;1.04). For the SOL, higher passive work was associated with reduced PO (Spearman's r=0.709, P&lt;0.001), but no relationship was observed between passive work and PO of the EDL (Pearson's r=0.191, r2=0.04, P=0.184). This study suggests that starting length should be optimised for both static and dynamic contractions and confirms that the force–length curve during dynamic contractions is muscle specific.
Contemporary theories of orthodontic tooth movement
Authors: Haworth Jennifer , Sandy Jonathan 
Published: April 2024

Coordinated biological responses are required to bring about orthodontic tooth movement. Several theories have been proposed for the mechanisms underlying tooth movement. Techniques have been investigated for reducing pain associated with orthodontics, as well as increasing the rate of tooth movement. Modern molecular and genetic techniques have improved our understanding of biological processes underlying tooth movement, but there is still a great deal of detail that is unknown. CPD/Clinical Relevance: This article provides an update on contemporary theories of orthodontic tooth movement.
Cementless total knee arthroplasty in young patients using tantalum trabecular implants results in significantly lower rates of aseptic loosening
Authors: Khetan Vatsal , Baxter Ian , Hampton Matthew , Spencer Amy , Anderson Alexander 
Published: April 2024

AimsThe mean age of patients undergoing total knee arthroplasty (TKA) has reduced with time. Younger patients have increased expectations following TKA. Aseptic loosening of the tibial component is the most common cause of failure of TKA in the UK. Interest in cementless TKA has re-emerged due to its encouraging results in the younger patient population. We review a large series of tantalum trabecular metal cementless implants in patients who are at the highest risk of revision surgery.MethodsA total of 454 consecutive patients who underwent cementless TKA between August 2004 and December 2021 were reviewed. The mean follow-up was ten years. Plain radiographs were analyzed for radiolucent lines. Patients who underwent revision TKA were recorded, and the cause for revision was determined. Data from the National Joint Registry for England, Wales, Northern Island, the Isle of Man and the States of Guernsey (NJR) were compared with our series.ResultsNo patients in our series had evidence of radiolucent lines on their latest radiological assessment. Only eight patients out of 454 required revision arthroplasty, and none of these revisions were indicated for aseptic loosening of the tibial baseplate. When compared to data from the NJR annual report, Kaplan-Meier estimates from our series (2.94 (95% confidence interval (CI) 1.24 to 5.87)) show a significant reduction in cumulative estimates of revision compared to all cemented (4.82 (95% CI 4.69 to 4.96)) or cementless TKA (5.65 (95% CI 5.23 to 6.10)). Our data (2.94 (95% CI 1.24 to 5.87)) also show lower cumulative revision rates compared to the most popular implant (PFC Sigma Cemented Knee implant fixation, 4.03 (95% CI 3.75 to 4.33)). The prosthesis time revision rate (PTIR) estimates for our series (2.07 (95% CI 0.95 to 3.83)) were lower than those of cemented cases (4.53 (95% CI 4.49 to 4.57)) from NJR.ConclusionThe NexGen trabecular (tantalum) cementless implant has lower revision rates in our series compared to all cemented implants and other types of cementless implants, and its use in younger patients should be encouraged.Cite this article: Bone Jt Open 2024;5(4):277–285.
Non-verbal predications in Zarma
Authors: Abdoulaye Mahamane L. , Abdoulrazikou Salimata 
Published: April 2024

This article presents new findings in the use of copulas nôo ‘be’ and ti ‘be’ in non-verbal predications in Zarma (Songhay; Niger, Nigeria). Based on some exclusive contexts of use and some morphosyntactic criteria, the article distinguishes a basic type of predication with one term “NP + nôo” used in deictic identification (e. g.: Abdù nôo ‘it’s Abdu’) and a type of predication with two terms “NP1 + NP2 + nôo” used in nominal predications and equative sentences (e. g.: wodìn Abdù nôo ‘that is Abdu’). The article shows that copula ti replaces copula nôo in negation but also in non-verbal focus constructions where it is generally preceded by the subordinating conjunction kà/gà and very likely marks the presupposed part of the sentence (e. g.: [Muusà nôo] kà ti càwkŏo ‘[it’s Musa] who is a student’). Finally, the article shows that in Zarma, it is the one-term predication “NP + nôo” that is recruited to mark focus-fronted constituents of verbal and non-verbal predications, thus confirming an observation already made about other languages.
Verschriftungsprinzipien im geschriebenen Dialekt: WhatsApp-Nachrichten aus Südtirol
Authors: Alber Birgit , Frey Jennifer-Carmen , Glaznieks Aivars , Glück Alexander , Kokkelmans Joachim 
Published: April 2024

Although the orthographic norm of the standard language has dominated most written registers of German, social media and other non-standardized digital contexts have recently given rise to the written use of dialects and vernaculars in informal communication. The written use of non-standard dialects is especially wide-spread in the south of the German-speaking area, e. g. in Switzerland, Bavaria, Austria and South Tyrol, where various studies have reported the use of dialectal forms in digital contexts such as Chatrooms, WhatsApp or Facebook (cf. Christen 2004; Glaznieks/Frey 2018). Using a corpus of South Tyrolean WhatsApp chats with corresponding audio recordings of the chat authors retelling the chat contents, we analyze four phonetic-phonological phenomena of Tyrolean dialects, characteristic of the southern German-speaking area: pre-consonantal s-retraction, the neutralization of the phonemes /p/ and /b/ in word-initial position, vowels undergoing umlaut or unrounding and the realisation of r in the coda of unstressed syllables. In particular, we analyze if and how these phenomena of the dialect are represented in the written form. The results show that Standard German graphematic conventions form the basis for most dialect spellings in WhatsApp chats. However, they are sometimes abandoned for the benefit of spellings that explicitly represent dialectal pronunciations. Interestingly, in some cases these dialectal spellings do not correspond to the pronunciation of the writers who, instead, opt for a pronunciation closer to that of the standard language.
Comparison of a two-wavelength pyrometer system and spectral pyrometry for high-temperature measurements
Authors: Aljohani Sama Badr , Alshunaifi Ibrahim A. , Alqahtani Naif B. , Alfarraj Bader A. 
Published: April 2024

A pyrometer system is an optically passive, non-intrusive method that uses thermal radiation law to determine temperature. It combines electronic and optical instruments to detect low-level signals of radiation measurements. Surface high-temperature measurements are successfully obtained using a two-wavelength pyrometer system. This study used a pyrometer system to achieve high stability, minimize errors due to changing emissivity, and remove background noise from the radiation measurement for surface high-temperature measurements. Temperature measurements were also obtained from Planck’s model, and the results were compared with logarithmic assumption. The precision of these measurements is improved through variable optimization of the instruments, validation of the data, and calibration of the pyrometer system. The 16 temperature measurements were obtained (800–1600°C temperature measurement range) with a correlation coefficient above 97%. The response time between temperature readings is within 785 µs. Furthermore, the high-temperature measurements were obtained with higher stability (±2.99∘C at 1600°C) and less error (less than 2.29% for Si sensor). In addition, the error of the temperature measurement was reduced from 5.33% to 0.86% at 850°C by using Planck’s model compared with using logarithmic assumption. A cooling system temperature is also optimized to reduce the error temperature reading. It was found to be at 10°C that the uncertainty was reduced from 2.29% at ambient temperature to 1.53% at 1600°C. The spectral pyrometry system was also used in comparison with the two-wavelength pyrometer system to confirm that the calibration curves of the spectral pyrometry can be used to determine temperature measurements.
O-band single-photon quantum key distributor master-to-slave injection-locked DFBLD pair
Authors: Tsou Cheng-Lin , Cheng Chih-Hsien , Matsumoto Atsushi , Akahane Kouichi , Lin Gong-Ru 
Published: April 2024

In comparison with the rapidly developing progress on the optical C-band (1525-1565 nm) master-to-slave injection-locked transmitter to perform the coherent single-photon quantum key distribution (QKD), the development on the O-band (1250-1350 nm) QKD transmitter is somewhat delayed as the commercially available wavelength-matched narrow-linewidth distributed feedback laser diode (DFBLD) pair is hardly accessible up to now. By using the DFBLDs with only sub-MHz linewidth and relatively deviated wavelength for the first time, this work demonstrates the optically differential-phase-shift-keying (DPS) QKD by an O-band master-to-slave injection-locked DFBLD pair. The master and slave DFBLDs with wavelength fluctuations of ±0.05% and ±0.2 pm are controlled by a thermo-electric cooler with a feedback gain of 100. The 1-bit delay interferometer (DI) under thermo-insulation maintains its visibility at >96% with dPo/Po and dPo/dt measured below ±0.1% and ±1 × 10−3 mW/s. By RZ-OOK modulating the master DFBLD with step-like power coding at 150 µW to induce π phase shift in the injection-locked slave DFBLD, the rising-/falling-edge DPS envelope distortion of the slave DFBLD diminishes by decreasing the bias current of the master DFBLD from 7Ith (35 mA) to 2Ith (10 mA). This phenomenon enables the 128-bit DPS-QKD transmission with a quantum bit-error rate (QBER) of 3.57% and a secure key rate of 3.524 kbit/s in the 6-km SMF link. The O-band injection-locked single-photon DPS-QKD bit-stream with a mean photon number of 0.2 #/bit minimizes its decoding QBER to 3.88% and 4.84% for 512-bit and 1024-bit, respectively.