bluuebunny/crossref_metadata_2025_split huggingface dataset:
How top leaders’ support affects open government data (OGD)-driven innovation capacity of firms: Based on the TOE framework perspective
Authors: Wang Yu , Jiang Hui , Han Delong , Zhou Mingle , Li Gang 
Published: March 2024

Abstract
The innovation value of open government data (OGD) drives firms to the participation in OGD-driven innovation. However, to fully excavate the innovation value of OGD for firms, it is essential to explore the factors and mechanisms that affect OGD-driven innovation capacity. On the basis of the technology–organization–environment (TOE) framework, a theoretical model affecting OGD-driven innovation capacity is proposed for analysis by partial least squares structural equation modeling with 236 sample data from China. The results indicate that top leaders’ support positively impacts on OGD-driven innovation capacity in firms. And we also prove that technical competence, organizational arrangement, and innovation support partially mediate the relationship between top leaders’ support and OGD-driven innovation capacity on the basis of the TOE framework. Consequently, the findings provide new research perspectives and practical guidance for promoting OGD-driven innovation capacity in firms.
Bringing the Constituents Back In: The Politics of Social Security in the 1950s
Authors: YELLIN ERIC S. 
Published: March 2024

AbstractThis article argues that scholars’ current understanding of Social Security policy making in the 1950s is missing a crucial component: massive letter-writing campaigns by ordinary Americans. Americans’ letters to Congress—and the responses of members and their aides in public debates and constituent correspondence—reflect a more vibrant, more democratic, and messier policy-making process than scholars have previously recognized. In the 1950s, Congress voted to amend the Social Security Act of 1935 repeatedly, expanding both the number of occupations covered by the Old Age and Survivors Insurance program and the level of benefits individuals received. Scholars have depicted this expansion as the work of planners within the Social Security bureaucracy. Yet, the letters in congressional records reveal that the process of amending Social Security resulted from—and helped create—constituencies of Americans who felt entitled to make claims on the federal state apparatus.
Prospective evaluation of acute neurological events after paediatric cardiac surgery
Authors: Frost Olivia , Ridout Deborah , Rodrigues Warren , Wellman Paul , Cassidy Jane , Tsang Victor T. , Dorobantu Dan , Stoica Serban C. , Hoskote Aparna , Brown Katherine L. 
Published: March 2024

AbstractObjectives:Children with CHD are at heightened risk of neurodevelopmental problems; however, the contribution of acute neurological events specifically linked to the perioperative period is unclear.Aims:This secondary analysis aimed to quantify the incidence of acute neurological events in a UK paediatric cardiac surgery population, identify risk factors, and assess how acute neurological events impacted the early post-operative pathway.Methods:Post-operative data were collected prospectively on 3090 consecutive cardiac surgeries between October 2015 and June 2017 in 5 centres. The primary outcome of analysis was acute neurological event, with secondary outcomes of 6-month survival and post-operative length of stay. Patient and procedure-related variables were described, and risk factors were statistically explored with logistic regression.Results:Incidence of acute neurological events after paediatric cardiac surgery in our population occurred in 66 of 3090 (2.1%) consecutive cardiac operations. 52 events occurred with other morbidities including renal failure (21), re-operation (20), cardiac arrest (20), and extracorporeal life support (18). Independent risk factors for occurrence of acute neurological events were CHD complexity 1.9 (1.1–3.2), p = 0.025, longer operation times 2.7 (1.6–4.8), p < 0.0001, and urgent surgery 3.4 (1.8–6.3), p < 0.0001. Unadjusted comparison found that acute neurological event was linked to prolonged post-operative hospital stay (median 35 versus 9 days) and poorer 6-month survival (OR 13.0, 95% CI 7.2–23.8).Conclusion:Ascertainment of acute neurological events relates to local measurement policies and was rare in our population. The occurrence of acute neurological events remains a suitable post-operative metric to follow for quality assurance purposes.
The Evolution of Hillslope Hydrology: Links Between Form, Function and the Underlying Control of Geology
Authors: Hartmann Anne , Blume Theresa 
Published: March 2024

AbstractForm and function are two major characteristics of hydrological systems. While form summarizes the structure of the system, function represents the hydrological response. Little is known about how these characteristics evolve and how form relates to function in young hydrological systems. We investigated how form and function evolve during the first millennia of landscape evolution. We analyzed two hillslope chronosequences in glacial forelands, one developed from siliceous and the other from calcareous parent material. Variables describing hillslope form included soil physical properties, surface, and vegetation characteristics. Variables describing hydrological function included soil water response times, soil water storage, drainage, and dominant subsurface flow types. We identified links between form and hydrological function via cluster analysis. Clusters identified based on form were compared in terms of their hydrological functioning. The comparison of the two different parent materials shows how strongly landscape evolution is controlled by the underlying geology. Soil pH appears to be a key variable influencing vegetation, soil formation and subsequently hydrology. At the calcareous site, the high buffering capacity of the soil leads to less soil formation and fast, vertical subsurface water transport dominates the water redistribution even after more than 10,000 years of landscape evolution. At the siliceous site, soil acidification results in accumulation of organic material, a high water storage capacity, and in podsolization. Under these conditions water redistribution changes from vertical subsurface water transport at the young age classes to water storage in the organic surface layer and lateral subsurface water transport within 10,000 years.
Serum autoantibodies against α7-nicotinic receptors in subgroups of patients with bipolar disorder or schizophrenia: clinical features and link with peripheral inflammation
Authors: Darrau Estelle , Jacquemet Elise , Pons Stéphanie , Schlick Laurène , Zouridakis Marios , Wu Ching-Lien , Richard Jean-Romain , Barau Caroline , Le Corvoisier Philippe , Yolken Robert , Tamouza Ryad , Leboyer Marion , Maskos Uwe 
Published: March 2024

AbstractThere is growing evidence that autoantibodies (AAbs) against proteins expressed in the brain are playing an important role in neurological and psychiatric disorders. Here, we explore the presence and the role of peripheral AAbs to the α7-nicotinic acetylcholine receptor (nAChR) in inflammatory subgroups of psychiatric patients with bipolar disorder (BD) or schizophrenia (SCZ) and healthy controls. We have identified a continuum of AAb levels in serum when employing a novel ELISA technique, with a significant elevation in patients compared to controls. Using unsupervised two-step clustering to stratify all the subjects according to their immuno-inflammatory background, we delineate one subgroup consisting solely of psychiatric patients with severe symptoms, high inflammatory profile, and significantly increased levels of anti-nAChR AAbs. In this context, we have used monoclonal mouse anti-human α7-nAChR antibodies (α7-nAChR-mAbs) and shown that TNF-α release was enhanced upon LPS stimulation in macrophages pre-incubated with α7-nAChR-mAbs compared to the use of an isotype control. These findings provide a basis for further study of circulating nicotinic AAbs, and the inflammatory profile observed in patients with major mood and psychotic disorders.
Hypoxia-induced miR-5100 promotes exosome-mediated activation of cancer-associated fibroblasts and metastasis of head and neck squamous cell carcinoma
Authors: Duan Yuansheng , Zhou Mengqian , Ye Beibei , Yue Kai , Qiao Feng , Wang Yuxuan , Lai Qingchuan , Wu Yue , Cao Jiayan , Wu Yansheng , Wang Xudong , Jing Chao 
Published: March 2024

AbstractThe invasion-metastasis cascade in head and neck squamous cell carcinoma (HNSCC) is predominantly caused by the interaction between tumor cells and tumor microenvironment, including hypoxia as well as stromal cells. However, the mechanism of hypoxia-activated tumor-stroma crosstalk in HNSCC metastasis remains to be deciphered. Here, we demonstrated that HIF1α was upregulated in HNSCC specimens compared with adjacent normal tissues, whose overexpression was associated with lymph node metastasis and predicted unfavorable prognosis. HIF1α expression correlated positively with the levels of miR-5100 as well as α-SMA, the marker of CAFs. Hypoxia/HIF1α regulated transcriptionally miR-5100 to promote the degradation of its target gene QKI, which acts as a tumor suppressor in HNSCC. Hypoxic HNSCC-derived exosomal miR-5100 promoted the activation of CAFs by orchestrating QKI/AKT/STAT3 axis, which further facilitated HNSCC metastasis. Additionally, miR-5100 derived from plasma exosomes indicated HNSCC malignant progression. In conclusion, our findings illuminate a novel HIF1α/miR-5100/QKI pathway in HNSCC metastasis, and suggest that miR-5100 might be a potential biomarker and therapeutic target for HNSCC.
Histidine re-sensitizes pediatric acute lymphoblastic leukemia to 6-mercaptopurine through tetrahydrofolate consumption and SIRT5-mediated desuccinylation
Authors: Dong Na , Ma Hui-Xian , Liu Xue-Qin , Li Dong , Liu Ling-Hong , Shi Qing , Ju Xiu-Li 
Published: March 2024

AbstractDespite progressive improvements in the survival rate of pediatric B-cell lineage acute lymphoblastic leukemia (B-ALL), chemoresistance-induced disease progression and recurrence still occur with poor prognosis, thus highlighting the urgent need to eradicate drug resistance in B-ALL. The 6-mercaptopurine (6-MP) is the backbone of ALL combination chemotherapy, and resistance to it is crucially related to relapse. The present study couples chemoresistance in pediatric B-ALL with histidine metabolism deficiency. Evidence was provided that histidine supplementation significantly shifts the 6-MP dose-response in 6-MP-resistant B-ALL. It is revealed that increased tetrahydrofolate consumption via histidine catabolism partially explains the re-sensitization ability of histidine. More importantly, this work provides fresh insights into that desuccinylation mediated by SIRT5 is an indispensable and synergistic requirement for histidine combination therapy against 6-MP resistance, which is undisclosed previously and demonstrates a rational strategy to ameliorate chemoresistance and protect pediatric patients with B-ALL from disease progression or relapse.
Engineered dityrosine-bonding of the RSV prefusion F protein imparts stability and potency advantages
Authors: Gidwani Sonal V. , Brahmbhatt Devarshi , Zomback Aaron , Bassie Mamie , Martinez Jennifer , Zhuang Jian , Schulze John , McLellan Jason S. , Mariani Roberto , Alff Peter , Frasca Daniela , Blomberg Bonnie B. , Marshall Christopher P. , Yondola Mark A. 
Published: March 2024

AbstractViral fusion proteins facilitate cellular infection by fusing viral and cellular membranes, which involves dramatic transitions from their pre- to postfusion conformations. These proteins are among the most protective viral immunogens, but they are metastable which often makes them intractable as subunit vaccine targets. Adapting a natural enzymatic reaction, we harness the structural rigidity that targeted dityrosine crosslinks impart to covalently stabilize fusion proteins in their native conformations. We show that the prefusion conformation of respiratory syncytial virus fusion protein can be stabilized with two engineered dityrosine crosslinks (DT-preF), markedly improving its stability and shelf-life. Furthermore, it has 11X greater potency as compared with the DS-Cav1 stabilized prefusion F protein in immunogenicity studies and overcomes immunosenescence in mice with simply a high-dose formulation on alum.
Triggered contraction of self-assembled micron-scale DNA nanotube rings
Authors: Illig Maja , Jahnke Kevin , Weise Lukas P. , Scheffold Marlene , Mersdorf Ulrike , Drechsler Hauke , Zhang Yixin , Diez Stefan , Kierfeld Jan , Göpfrich Kerstin 
Published: March 2024

AbstractContractile rings are formed from cytoskeletal filaments during cell division. Ring formation is induced by specific crosslinkers, while contraction is typically associated with motor protein activity. Here, we engineer DNA nanotubes and peptide-functionalized starPEG constructs as synthetic crosslinkers to mimic this process. The crosslinker induces bundling of ten to hundred DNA nanotubes into closed micron-scale rings in a one-pot self-assembly process yielding several thousand rings per microliter. Molecular dynamics simulations reproduce the detailed architectural properties of the DNA rings observed in electron microscopy. Theory and simulations predict DNA ring contraction – without motor proteins – providing mechanistic insights into the parameter space relevant for efficient nanotube sliding. In agreement between simulation and experiment, we obtain ring contraction to less than half of the initial ring diameter. DNA-based contractile rings hold promise for an artificial division machinery or contractile muscle-like materials.
The atlas of unburnable oil for supply-side climate policies
Authors: Pellegrini Lorenzo , Arsel Murat , Muñoa Gorka , Rius-Taberner Guillem , Mena Carlos , Orta-Martínez Martí 
Published: March 2024

AbstractTo limit the increase in global mean temperature to 1.5 °C, CO2 emissions must be drastically reduced. Accordingly, approximately 97%, 81%, and 71% of existing coal and conventional gas and oil resources, respectively, need to remain unburned. This article develops an integrated spatial assessment model based on estimates and locations of conventional oil resources and socio-environmental criteria to construct a global atlas of unburnable oil. The results show that biodiversity hotspots, richness centres of endemic species, natural protected areas, urban areas, and the territories of Indigenous Peoples in voluntary isolation coincide with 609 gigabarrels (Gbbl) of conventional oil resources. Since 1524 Gbbl of conventional oil resources are required to be left untapped in order to keep global warming under 1.5 °C, all of the above-mentioned socio-environmentally sensitive areas can be kept entirely off-limits to oil extraction. The model provides spatial guidelines to select unburnable fossil fuels resources while enhancing collateral socio-environmental benefits.
Ultra-fast switching memristors based on two-dimensional materials
Authors: Teja Nibhanupudi S. S. , Roy Anupam , Veksler Dmitry , Coupin Matthew , Matthews Kevin C. , Disiena Matthew , Ansh  , Singh Jatin V. , Gearba-Dolocan Ioana R. , Warner Jamie , Kulkarni Jaydeep P. , Bersuker Gennadi , Banerjee Sanjay K. 
Published: March 2024

AbstractThe ability to scale two-dimensional (2D) material thickness down to a single monolayer presents a promising opportunity to realize high-speed energy-efficient memristors. Here, we report an ultra-fast memristor fabricated using atomically thin sheets of 2D hexagonal Boron Nitride, exhibiting the shortest observed switching speed (120 ps) among 2D memristors and low switching energy (2pJ). Furthermore, we study the switching dynamics of these memristors using ultra-short (120ps-3ns) voltage pulses, a frequency range that is highly relevant in the context of modern complementary metal oxide semiconductor (CMOS) circuits. We employ statistical analysis of transient characteristics to gain insights into the memristor switching mechanism. Cycling endurance data confirms the ultra-fast switching capability of these memristors, making them attractive for next generation computing, storage, and Radio-Frequency (RF) circuit applications.
Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models
Authors: Kaiser Franziska K. , Hernandez Mariana Gonzalez , Krüger Nadine , Englund Ellinor , Du Wenjuan , Mykytyn Anna Z. , Raadsen Mathijs P. , Lamers Mart M. , Rodrigues Ianiski Francine , Shamorkina Tatiana M. , Snijder Joost , Armando Federico , Beythien Georg , Ciurkiewicz Malgorzata , Schreiner Tom , Gruber-Dujardin Eva , Bleyer Martina , Batura Olga , Erffmeier Lena , Hinkel Rabea , Rocha Cheila , Mirolo Monica , Drabek Dubravka , Bosch Berend-Jan , Emalfarb Mark , Valbuena Noelia , Tchelet Ronen , Baumgärtner Wolfgang , Saloheimo Markku , Pöhlmann Stefan , Grosveld Frank , Haagmans Bart L. , Osterhaus Albert D.M.E. 
Published: March 2024

AbstractMonoclonal antibodies are an increasingly important tool for prophylaxis and treatment of acute virus infections like SARS-CoV-2 infection. However, their use is often restricted due to the time required for development, variable yields and high production costs, as well as the need for adaptation to newly emerging virus variants. Here we use the genetically modified filamentous fungus expression system Thermothelomyces heterothallica (C1), which has a naturally high biosynthesis capacity for secretory enzymes and other proteins, to produce a human monoclonal IgG1 antibody (HuMab 87G7) that neutralises the SARS-CoV-2 variants of concern (VOCs) Alpha, Beta, Gamma, Delta, and Omicron. Both the mammalian cell and C1 produced HuMab 87G7 broadly neutralise SARS-CoV-2 VOCs in vitro and also provide protection against VOC Omicron in hamsters. The C1 produced HuMab 87G7 is also able to protect against the Delta VOC in non-human primates. In summary, these findings show that the C1 expression system is a promising technology platform for the development of HuMabs in preventive and therapeutic medicine.
Capturing ion trapping and detrapping dynamics in electrochromic thin films
Authors: Zhang Renfu , Zhou Qinqi , Huang Siyuan , Zhang Yiwen , Wen Rui-Tao 
Published: March 2024

AbstractIon trapping has been found to be responsible for the performance degradation in electrochromic oxide thin films, and a detrapping procedure was proved to be effective to rejuvenate the degraded films. Despite of the studies on ion trapping and detrapping, its dynamics remain largely unknown. Moreover, coloration mechanisms of electrochromic oxides are also far from clear, limiting the development of superior devices. Here, we visualize ion trapping and detrapping dynamics in a model electrochromic material, amorphous WO3. Specifically, formation of orthorhombic Li2WO4 during long-term cycling accounts for the origin of shallow traps. Deep traps are multiple-step-determined, composed of mixed W4+-Li2WO4, amorphous Li2WO4 and W4+-Li2O. The non-decomposable W4+-Li2WO4 couple is the origin of the irreversible traps. Furthermore, we demonstrate that, besides the typical small polaron hopping between W5+ ↔ W6+ sites, bipolaron hopping between W4+ ↔ W6+ sites gives rise to optical absorption in the short-wavelength region. Overall, we provide a general picture of electrochromism based on polaron hopping. Ion trapping and detrapping were demonstrated to also prevail in other cathodic electrochromic oxides. This work not only provides the ion trapping and detrapping dynamics of WO3, but also open avenues to study other cathodic electrochromic oxides and develop superior electrochromic devices with great durability.
The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans
Authors: Emerson Felicity J. , Chiu Caitlin , Lin Laura Y. , Riedel Christian G. , Zhu Ming , Lee Siu Sylvia 
Published: March 2024

AbstractSET-26, HCF-1, and HDA-1 are highly conserved chromatin factors with key roles in development and aging. Here we present mechanistic insights into how these factors regulate gene expression and modulate longevity in C. elegans. We show that SET-26 and HCF-1 cooperate to regulate a common set of genes, and both antagonize the histone deacetylase HDA-1 to limit longevity. HCF-1 localization at chromatin is largely dependent on functional SET-26, whereas SET-26 is only minorly affected by loss of HCF-1, suggesting that SET-26 could recruit HCF-1 to chromatin. HDA-1 opposes SET-26 and HCF-1 on the regulation of a subset of their common target genes and in longevity. Our findings suggest that SET-26, HCF-1, and HDA-1 comprise a mechanism to fine-tune gene expression and longevity and likely have important implications for the mechanistic understanding of how these factors function in diverse organisms, particularly in aging biology.
Monolithic thin-film lithium niobate broadband spectrometer with one nanometre resolution
Authors: Finco Giovanni , Li Gaoyuan , Pohl David , Reig Escalé Marc , Maeder Andreas , Kaufmann Fabian , Grange Rachel 
Published: March 2024

AbstractMiniaturised optical spectrometers are attractive due to their small footprint, low weight, robustness and stability even in harsh environments such as space or industrial facilities. We report on a stationary-wave integrated Fourier-transform spectrometer featuring a measured optical bandwidth of 325 nm and a theoretical spectral resolution of 1.2 nm. We fabricate and test on lithium niobate-on-insulator to take full advantage of the platform, namely electro-optic modulation, broad transparency range and the low optical loss achieved thanks to matured fabrication techniques. We use the electro-optic effect and develop innovative layouts to overcome the undersampling limitations and improve the spectral resolution, thus providing a framework to enhance the performance of all devices sharing the same working principle. With our work, we add another important element to the portfolio of integrated lithium-niobate optical devices as our spectrometer can be combined with multiple other building blocks to realise functional, monolithic and compact photonic integrated circuits.
Si/SiGe QuBus for single electron information-processing devices with memory and micron-scale connectivity function
Authors: Xue Ran , Beer Max , Seidler Inga , Humpohl Simon , Tu Jhih-Sian , Trellenkamp Stefan , Struck Tom , Bluhm Hendrik , Schreiber Lars R. 
Published: March 2024

AbstractThe connectivity within single carrier information-processing devices requires transport and storage of single charge quanta. Single electrons have been adiabatically transported while confined to a moving quantum dot in short, all-electrical Si/SiGe shuttle device, called quantum bus (QuBus). Here we show a QuBus spanning a length of 10 μm and operated by only six simply-tunable voltage pulses. We introduce a characterization method, called shuttle-tomography, to benchmark the potential imperfections and local shuttle-fidelity of the QuBus. The fidelity of the single-electron shuttle across the full device and back (a total distance of 19 μm) is (99.7 ± 0.3) %. Using the QuBus, we position and detect up to 34 electrons and initialize a register of 34 quantum dots with arbitrarily chosen patterns of zero and single-electrons. The simple operation signals, compatibility with industry fabrication and low spin-environment-interaction in 28Si/SiGe, promises long-range spin-conserving transport of spin qubits for quantum connectivity in quantum computing architectures.