bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advantages of laparoscopic segmentectomy of the liver using ICG fluorescent navigation by the negative staining method: A comparison with open procedure
Authors: Araki Kenichiro , Watanabe Akira , Harimoto Norifumi , Igrashi Takamichi , Tsukagoshi Mariko , Ishii Norihiro , Kawai Shunsuke , Hagiwara Kei , Hoshino Kouki , Shirabe Ken 
Published: March 2024

AbstractAimLaparoscopic segmentectomy (LS) using indocyanine green (ICG) fluorescence navigation with negative staining method has potential for performing accurate and safe anatomical excision. This study aimed to evaluate the significance of LS using ICG fluorescence navigation compared with open segmentectomy (OS).MethodsEighty‐seven patients who underwent anatomical segmentectomies were evaluated for OS (n = 44) and LS (n = 43). The Glissonean pedicle approach was performed using either extra‐ or intrahepatic method, depending on the location of segment in LS. After clamping pedicle, negative staining method was performed. Liver transection was done along intersegmental plane visualizing by overlay mode of ICG camera. Surgical outcomes were compared between two groups. Correlation between predicted resecting liver volume (PRLV) calculated using volumetry and actual resected liver volume (ARLV) was assessed in two groups.ResultsPatients who underwent LS showed better outcomes in operative time, blood loss, and length of hospital stay. There were significantly fewer Grade II and Grade III or higher postoperative complications in LS group. Both values of AST (p < 0.001) and ALT (p < 0.001) on postoperative day 1 were significantly lower in LS group than in OS group. PRLV and ARLV were more strongly correlated in LS (r = 0.896) than in OS (r = 0.773). The difference between PRLV and ARLV was significantly lower in LS group than in OS group (p = 0.022), and this trend was particularly noticeable in posterosuperior segment (p = 0.008) than in anterolateral segment (p = 0.811).ConclusionLS using ICG navigation allows precise resection and may contribute to safer short‐term outcomes than OS, particularly in posterosuperior segment.
Changing hemostatic management in post‐partum hemorrhage
Authors: Rigouzzo Agnès , Froissant Pierre‐Antoine , Louvet Nicolas 
Published: March 2024

AbstractEarly and fast assessment of hemostasis during postpartum hemorrhage (PPH) is essential to allow early characterization of coagulopathy, estimate bleeding severity and improve outcome. During PPH, fibrinogen decrease occurs earlier than other coagulation factors deficiency and hypofibrinogenemia is an early marker of PPH severity of progression. With good evidence in the context of PPH, point‐of‐care viscoelastic (VET) hemostatic assays have been shown to provide rapid assessment of hemostatic disorders, low fibrinogen levels, and allow VET‐guided fibrinogen replacement. Further studies are needed to define the thresholds for the other coagulation parameters.
Optimizing Intermediate Adsorption over PdM (M=Fe, Co, Ni, Cu) Bimetallene for Boosted Nitrate Electroreduction to Ammonia
Authors: Zhou Yuanbo , Zhang Lifang , Zhu Zebin , Wang Mengfan , Li Najun , Qian Tao , Yan Chenglin , Lu Jianmei 
Published: March 2024

AbstractElectrochemical reduction of nitrate to ammonia (NO3RR) is a promising and eco‐friendly strategy for ammonia production. However, the sluggish kinetics of the eight‐electron transfer process and poor mechanistic understanding strongly impedes its application. To unveil the internal laws, herein, a library of Pd‐based bimetallene with various transition metal dopants (PdM (M=Fe, Co, Ni, Cu)) are screened to learn their structure–activity relationship towards NO3RR. The ultra‐thin structure of metallene greatly facilitates the exposure of active sites, and the transition metals dopants break the electronic balance and upshift its d‐band center, thus optimizing intermediates adsorption. The anisotropic electronic characteristics of these transition metals make the NO3RR activity in the order of PdCu>PdCo≈PdFe>PdNi>Pd, and a record‐high NH3 yield rate of 295 mg h−1 mgcat−1 along with Faradaic efficiency of 90.9 % is achieved in neutral electrolyte on PdCu bimetallene. Detailed studies further reveal that the moderate N‐species (*NO3 and *NO2) adsorption ability, enhanced *NO activation, and reduced HER activity facilitate the NH3 production. We believe our results will give a systematic guidance to the future design of NO3RR catalysts.
Characterization of extruded films based on poly (butylene succinate) blends to utilize a partially degraded poly (butylene adipate‐co‐terephthalate)
Authors: Conceição Pietro Carlos Gonçalves , Lemos Paulo Vitor França , Santana Jamile Santos , Correia Paulo Romano Cruz , Cardoso Lucas Guimarães , de Jesus Assis Denílson , da Rocha Lucimar Pacheco Gomes , Marcelino Henrique Rodrigues , de Souza Ferreira Ederlan , da Silva Jania Betânia Alves , de Souza Carolina Oliveira 
Published: March 2024

AbstractPolymer blends can improve material processability and can be used to extrude partially degraded materials, such as expired poly (butylene adipate‐co‐terephthalate) (PBAT), which cannot be normally extruded. Therefore, in this study, the extrudability of PBAT that has passed its expiration date was restored by blending it with poly (butylene succinate) (PBS). Various polymer blends were extruded and characterized to achieve high‐efficiency extrusion. The carbonyl indices in partially degraded PBAT and the corresponding control sample detailed the effects of 98 months of aging on molecular properties. The semicrystalline structure consisted of a mixed ordered arrangement of PBS and PBAT chains dispersed in an amorphous matrix. The microscopic images of the surfaces of the polymer films revealed defects and roughness, followed by an increase in the PBAT concentration in blends. Changes in mechanical properties and water vapor permeability correlated with the PBAT concentration in the blends. To avoid polymer loss, we reported a simple method for using PBAT that has passed its expiration date and cannot be extruded. The results revealed that the polymer films could be used in the packaging industry, especially in food and agricultural sectors.
New urban habitat for endangered humpback whales: San Francisco Bay
Authors: Markowitz Tim M. , Keener William , Webber Marc A. , Payne Allison R. , Lane Rebekah S. , Fahlbusch James A. , Calambokidis John 
Published: March 2024

Abstract
As populations of large whales recover from whaling, species that forage and breed in coastal waters, including the humpback whale (Megaptera novaeangliae), increasingly overlap with human activities. This represents a potential hazard in locations worldwide subject to intensive vessel traffic, including New York, Panama City and Brisbane.
Historically, humpback whales were not considered part of San Francisco Bay's fauna, except for a few ‘lost’ whales that wandered into the estuary.
An unprecedented influx of humpback whales into highly urbanized San Francisco Bay began in 2016. Research efforts in 2016–2018 from vessels and shore resulted in 496 photo‐identification records plus 319 visual sightings. Sixty‐one individuals were photo‐identified, of which 80% (n = 49) used the bay on multiple days (range = 2 to 39), and 34% (n = 21) were resighted in successive years.
Whales photographed in San Francisco Bay were found to belong to distinct population segments listed as endangered and threatened under the U.S. Endangered Species Act.
Whales moved in and out of the bay seasonally (April–November). Habitat use patterns indicated movements farther into San Francisco Bay correlated positively with high tides.
Humpback whales were visually observed lunge feeding on northern anchovy (Engraulis mordax) at the surface. Analysis of dive patterns by three tagged whales confirmed subsurface feeding when surface feeding was not apparent.
The use of San Francisco Bay and adjacent waters by recovering populations of humpback whales exacerbates the potential for collisions with vessels, entanglement in fishing gear, and harassment by recreational vessels. The most pressing conservation concern is the risk of ship strikes, observed where humpback whales occur near active seaports.
Frustrated Lewis Pair‐Type Reactivity of Intermolecular Rare‐Earth Aryloxide and N‐Heterocyclic Carbene/Olefin Combinations
Authors: Guan Yiwen , Chang Kejian , Su Yujie , Xu Xian , Xu Xin 
Published: March 2024

AbstractThis work reports the cooperative reactivity of rare‐earth aryloxide complexes with N‐heterocyclic carbene (NHC) or N‐heterocyclic olefin (NHO), showcasing their synergistic effect on the activation of H2 and diverse organic substrates. Reactions of RE(OAr)3 (RE=La, Sm, and Y; Ar=2,6‐tBu2−C6H3) with unsaturated NHC ItBu (:C[N(R)CH]2, R=tBu) isolated abnormally bound RE metal NHC complexes RE/aNHC. In contrast, no metal‐NHO adducts were formed when RE(OAr)3 were treated with NHO (R2C=C[N(R)C(R)]2, R=CH3). Both RE/aNHC and RE/NHO Lewis pairs enabled cooperative H2 activation. Furthermore, RE(OAr)3 were found to catalyze the hydrogenation of the exocyclic C=C double bond of NHO under mild conditions. Moreover, treatment of the La/aNHC complex with benzaldehyde produced a La/C4 1,2‐addition product. The La/NHO Lewis pair could react with (trimethylsilyl)diazomethane and α, β‐conjugated imine, affording an isocyanotrimethylsilyl lanthanum amide complex and a La/C 1,4‐addition product, respectively.
Zum Tragverhalten von mechanischen Verbindungsmitteln in Stahl‐Holz‐Verbunddecken
Authors: Krinitzki Christopher , Hartz Christian 
Published: March 2024

AbstractIm Kontext der nachhaltigen Tragwerksplanung wird am Lehrstuhl Tragkonstruktionen der TU Dortmund aktuell an einer Stahl‐Holz‐Verbunddecke (SHV) geforscht. Die Leistungsfähigkeit des Deckensystems hängt neben den verwendeten Materialien insbesondere von der konstruktiven Durchbildung der Verbundfuge ab. Demnach wurden zu Beginn der Forschungsarbeiten verschiedene Fugenkonfigurationen mit reversiblen mechanischen Verbindungsmitteln experimentell untersucht. Im Zuge der durchgeführten Abscherversuche konnten die Vorzüge von senkrecht zur Holzfaser eingebrachten Holzschrauben (HS) im Vergleich zu selbstbohrenden Blechbohrschrauben (BS) sowie geneigt eingebrachten Holzschrauben festgestellt werden. Die senkrecht installierten Holzschrauben wiesen eine vergleichsweise hohe Verbundsteifigkeit sowie einen ausgeprägt duktilen Versagensmechanismus bei gleichzeitig geringem Montageaufwand auf. Dementsprechend werden in zukünftigen versuchstechnischen Untersuchungen zur Erfassung des Biegetragverhaltens der Stahl‐Holz‐Verbunddecke überwiegend senkrecht eingebrachte Holzschrauben zur Sicherstellung des Verbunds vorgesehen.
Iranian adaptation of the Epistemic Trust, Mistrust, and Credulity Questionnaire (ETMCQ): Validity, reliability, discriminant ability, and sex invariance
Authors: Asgarizadeh Ahmad , Ghanbari Saeed 
Published: March 2024

AbstractIntroductionEpistemic trust, or trust in transmitted knowledge, has been proposed as a critical factor in psychopathology and psychotherapy. This study aimed at evaluating the psychometric properties of the Epistemic Trust, Mistrust, and Credulity Questionnaire (ETMCQ) in Iran.MethodData were collected from 906 participants. Along with the ETMCQ, measures of mentalizing, mindfulness, perspective‐taking, attachment, emotion dysregulation, and borderline personality disorder were administered. Confirmatory factor analysis and exploratory structural equation modeling (ESEM) were used to determine factorial structure.ResultsThe ESEM model showed an acceptable fit and outperformed the confirmatory model. A 14‐item version of the ETMCQ was retained after examining item performance. Our findings also established criterion‐related validity for mistrust and credulity, an acceptable internal consistency for credulity, discriminant power for mistrust and credulity in detecting positive screens for borderline personality disorder, and measurement invariance across sexes.ConclusionThis study provides evidence for the cross‐cultural applicability of the ETMCQ. Nonetheless, the validity of the trust and internal consistency of the mistrust subscale require particular attention in future research.
Integration of rapid bioburden testing into production quality management systems and process control
Authors: Ramos Irina , Najera Michelle , Schaefer Gene 
Published: March 2024

AbstractThe move to integrated continuous bioprocessing (ICB), while providing a means for process intensification, can put added strain on process analytics when conventional methods are used. For instance, traditional microbial methods provide minimal value to ICB processes given that the time required for data to become available is much longer than a typical full cycle of the manufacturing process. Although rapid microbial detection has been in discussion for over 30 years, it is still not routinely deployed in commercial biopharmaceutical manufacturing. One contributing factor is the ability to integrate this technology into a process control strategy and existing quality systems. An understanding of the capability of microbial detection technology available today can be leveraged to implement a control strategy for bioburden monitoring in real time for process intermediates. One key tenet of this proposed control strategy is the use of a “two‐tiered approach” wherein a fast (but possibly less sensitive) test is used to monitor the process and trigger further action for a second, longer duration test which is used to confirm and quantify the presence of bioburden and identify the organism. This approach, presented here alongside several case studies for microbial monitoring, can have broader application for other process analytical technologies where fit for purpose methods could be employed to establish process control alongside real time continuous processes.
Leveraging bioanalytical characterization of fractionated monoclonal antibody pools to identify aggregation‐prone and less filterable proteoforms during virus filtration
Authors: Isu Solomon , Vinskus Lilia , Silva Derek , Cunningham Kristina , Elich Thomas , Greenhalgh Patricia , Sokolnicki Adam , Raghunath Bala 
Published: March 2024

AbstractMonoclonal antibodies (mAbs) are an essential class of biotherapeutics. A platform process is used for mAb development to ensure clinically safe and stable molecules. Regulatory authorities ensure that mAb production processes include sufficient viral clearance steps to achieve less than one virus particle per million doses of product. Virus filtration is used for size‐based removal of enveloped and nonenveloped viruses during downstream processing of mAbs. Process development in mAb purification relies on empirical approaches and often includes adsorptive prefiltration to mitigate virus filter fouling. Opportunities for molecular‐level prediction of mAb filterability are needed to plug the existing knowledge gap in downstream processing. A molecular‐level approach to understanding the factors influencing mAb filterability may reduce process development time, material loss, and processing costs due to oversized virus filters. In this work, pH step gradient fractionation was applied on polished bulk mAb feed to obtain concentrated pools of fractionated mAb variants. Biophysical properties and quality attributes of fractionated pools, including oligomeric state (size), isoelectric point profile, diffusion interaction parameters, and glycoform profile, were determined using bioanalytical methods. Filterability (loading and throughput) of fractionated pools were evaluated. Statistical methods were used to obtain correlations between quality attributes of mAb fractions and filterability on the Viresolve Pro virus filter.
Stable Isotope Tracer Technique and Network Pharmacology to Reveal Antidepressant Targets and Active Components of Xiaoyao San
Authors: Tian Junsheng , Wang Xianxian , Wu Wenze , Zhao Yunhao , Ling‐hu Ting , Qin Xuemei 
Published: March 2024

AbstractIn recent years, the research of mitochondrial dysfunction in depression has drawn the focus of researchers. Our research group previously found that Xiaoyao San (XYS) has improved the mitochondrial structure and the blocked tricarboxylic acid cycle (TCA cycle) in the hippocampal tissue of chronic unpredictable mild stress (CUMS) rats. However, the specific targets and active components of XYS remain unclear, and the potential to improve hippocampal mitochondrial TCA cycle disorder was also unexplored. In this research, a strategy to combine stable isotope‐resolved metabolomics (SIRM), network pharmacology and transmission electron microscopy (TEM) was used to explore the potential, targets of action, and active components of XYS to improve hippocampal mitochondrial TCA cycle disorder of CUMS rats. The results of TEM showed that the ultrastructure of hippocampal mitochondria could be improved by XYS. A combination of SIRM and molecular docking showed that pyruvate carboxylase (PC), ATP citrate lyase (ACLK), glutamate dehydrogenase (GLDH), glutamate oxaloacetate transaminase (GOT) and pyruvate dehydrogenase (PDH) were targets of XYS to improve TCA cycle disorder. In addition, troxerutin was found to be the most potential active component of XYS to improve TCA cycle disorder. The above research results can provide new insights for the development of antidepressant drugs.
Discovery of 6‐Acylamino/Sulfonamido Benzoxazolone with IL‐6 Inhibitory Activity as Promising Therapeutic Agents for Ulcerative Colitis
Authors: Ge Rui , Song Jiaqi , Cao Zhen , Ban Shurong , Tang Li , Li Qing‐shan 
Published: March 2024

AbstractUlcerative colitis has been widely concerned for its persistent upward trend, and the sustained overproduction of pro‐inflammatory cytokines such as IL‐6 remains a crucial factor in the development of UC. Therefore, the identification of new effective drugs to block inflammatory responses is an urgent and viable therapeutic strategy for UC. In our research, twenty‐three 6‐acylamino/sulfonamido benzoxazolone derivatives were synthesized, characterized, and evaluated for anti‐inflammatory activity against NO and IL‐6 production in LPS‐induced RAW264.7 cells. The results demonstrated that most of the target compounds were capable of reducing the overexpression of NO and IL‐6 to a certain degree. For the most active compounds 3i, 3j and 3 l, the inhibitory activities were superior or equivalent to those of the positive drug celecoxib with a dose‐dependent relationship. Furthermore, animal experiments revealed that active derivatives 3i, 3j and 3 l exhibited definitive therapeutical effect on DSS induced ulcerative colitis in mice by mitigating weight loss and DAI score while decreasing levels of pro‐inflammatory cytokines such as IL‐6 and IFN‐γ, simultaneously increasing production of anti‐inflammatory cytokines IL‐10. In addition, compounds 3i, 3j and 3 l could also inhibit the oxidative stress to alleviate ulcerative colitis by decreasing MDA and MPO levels. These finding demonstrated that compounds 3i, 3j and 3 l hold significant potential as novel therapeutic agents for ulcerative colitis.
Selective Partial Reduction of Nitroarenes to the Hydrazoarene Catalyzed by Amine‐Modified Ordered Mesoporous Silica Immobilized Ionic Liquid (OMSIIL) Stabilised RuNPs
Authors: Doherty S. , Knight J. G. , Alharbi A. A. , Wills C. , Dixon C. , Cheng C. , Russo Abegão F. , Chamberlain T. W. , Yan H. , Griffiths A. , Bourne R. A. , Collins S. M. , Wu K.‐J. , Alshaikh. H. 
Published: March 2024

AbstractRuthenium nanoparticles stabilised by an amine‐modified Ordered Mesoporous Silica Immobilized Ionic Liquid (OMSIIL) are efficient catalysts for the partial reduction of nitrobenzene to hydrazobenzene with 100 % selectivity as well as the complete reduction to aniline. High selectivity for the partial reduction of nitrobenzene to hydrazobenzene was obtained when the reaction was conducted in ethanol with 0.5 mol% catalyst and NaBH4 as the hydrogen donor whereas aniline was obtained as the sole product in water when dimethylamine borane (DMAB) was used as the hydrogen donor. Interestingly, while a range of electron poor nitroarenes were reduced to the corresponding hydrazoarene with high selectivities and good conversions, nitroarenes substituted with electron donating groups resulted in complete reduction to the aniline. Composition‐time profiles suggest that reductions conducted in ethanol with sodium borohydride occur via the condensation pathway while those conducted in water using dimethylamine borane as the hydrogen source may well go via the direct pathway. This is the first example of the selective reduction of nitrobenzene to hydrazobenzene using a ruthenium nanoparticle‐based catalyst and the initial TOF of 320 mol nitrobenzene converted mol Ru−1 h−1 for the partial reduction of nitrobenzene to hydrazobenzene is markedly higher than previous literature reports. A study of the catalyst performance as a function of the surface modification revealed that each component has a direct and dramatic effect on the efficacy as RuNPs stabilised by COK‐12 modified with imidazolium‐based ionic liquid and a primary amine gave the highest conversion while selective removal of either component or replacement of the primary amine with a tertiary amine resulted in a marked reduction in efficiency.
Recent Progress of the Application of Electropolymerization in Batteries and Supercapacitors: Specific Design of Functions in Electrodes
Authors: Lin Shengxuan , Wu Qingping , Lu Yan 
Published: March 2024

AbstractElectrochemical energy storage devices play a vital role in human life, and the requirements for their sustainability and environmental friendliness have been increasing in recent years. Electropolymerization, as a convenient method for polymer synthesis, has attracted increasing attentions in applications in the field of energy storage and conversion. It is not only commonly employed for the fabrication of various self‐supporting electrodes, but also is one of the most promising preparation strategies for organic electrode materials, internal interlayers within electrodes, functional protective layers, and current collector surface modifications. Previously published works have confirmed that the introduction of electropolymerization can effectively improve the electrochemical performance of various energy storage devices. However, there are still challenges in the universality of the synthesis route, in‐depth understanding of interface chemical behavior, and scaled‐up production. This mini review summarizes the main components in electropolymerization, material synthesis mechanisms, and their application principles in batteries and supercapacitors. Additionally, the current challenges and future development directions of electropolymerization have been discussed, offering some perspectives for further exploration.
7Li NMR Spectroscopy: A Tool for Determining Dimerization Constants and Averaged Dimerization Constants of the Monomer/Dimer Equilibrium of Hierarchical Helicates
Authors: Krückel Tobias , Schauerte Steffen , Ke Jinbo , Schlottmann Marcel , Bausch Sandra , Chen Xiaofei , Räuber Christoph , Almeida Silva Igor d'Anciães , Wiegand Thomas , Albrecht Markus 
Published: March 2024

Abstract7Li nuclear magnetic resonance (NMR) spectroscopy is an ideal tool to study hierarchically assembled helicates of the form Li[Li3L6Ti2]. Internally bound and external lithium ions can be well distinguished by solution‐ or solid‐state NMR spectroscopy and dimerization constants of the monomer/dimer equilibrium can be easily determined in solution. Averaged dimerization constants can be estimated in case of statistical mixtures of helicates formed from mixtures of ligands.