bluuebunny/crossref_metadata_2025_split huggingface dataset:
What is a sentinel node? Re‐evaluating the 10% rule for sentinel lymph node biopsy in melanoma
Authors: Kroon Hidde M. , Lowe Lori , Wong Sandra , Fullen Doug , Su Lyndon , Cimmino Vincent , Chang Alfred E. , Johnson Timothy , Sabel Michael S. 
Published: March 2007

AbstractIntroductionMany surgeons use the “10% rule” to define whether a lymph node is a sentinel node (SLN) when staging malignant melanoma. However, this increases the number of SLN removed and the time and cost of the procedure. We examined the impact of raising this threshold on the accuracy of the procedure.MethodsWe reviewed the records of 561 patients with melanoma (624 basins) who underwent SLN with technetium Tc99 labeled sulfur colloid using a definition of a SLN as 10% of that of the node with the highest counts per minute (CPM).ResultsOf the 624 basins, 154 (25%) were positive for metastases. An average of 1.9 nodes per basin were removed (range 1–6). Metastases were found in the hottest node in 137 cases (89% of positive basins, 97% of basins overall). Increasing the threshold above 10% decreased the number of nodes excised and the costs involved, but incrementally raised the number of false negative cases above baseline (a 4% increase for a “20% rule,” 5% for a “30% rule,” 6% for a “40% rule,” and 7% for a “50% rule”). Taking only the hottest node would raise the false negative rate by 11%.ConclusionsAlthough using thresholds higher than 10% for the definition of a SLN will minimize the extent of surgery and decrease the costs associated with the procedure, it will compromise the accuracy of the procedure and is not recommended. J. Surg. Oncol. 2007;95:623–628. © 2007 Wiley‐Liss, Inc.
Local and distant control in non‐metastatic pelvic Ewing's sarcoma patients
Authors: Donati Davide , Yin Junqiang , Di Bella Claudia , Colangeli Marco , Bacci Gaetano , Ferrari Stefano , Bertoni Franco , Barbieri Enza , Mercuri Mario 
Published: March 2007

AbstractBackground and objectivesDue to possible complication and loss of function, surgery is not often indicated in pelvic Ewing's sarcoma (ES). The purpose of this study was to review our experience and evaluate the role of different local treatment in non‐metastatic pelvic ES patients.MethodsOne hundred twenty‐nine patients with pelvic ES were treated at our institution between 1975 and 1999. We excluded patients presenting metastases, patients who had died of other causes, or those with incomplete clinical documentation. Among the 73 eligible patients, 17 (23%) with progression of tumor growth during induction chemotherapy eventually died. The analysis was focused on the remaining 56 patients with good or stable clinical response to the chemotherapy.ResultsPatients treated with surgery, with or without radiation therapy, had a better local control (82.6% vs. 66.7%) and a significantly higher rate of 5‐year EFS (73.9% vs. 30.3%, P = 0.036) than those who were only treated with local radiation therapy.ConclusionChemotherapy is the key factor in the treatment of pelvic ES. In our series, surgical treatment was associated with good prognosis for pelvic ES. The use of radiotherapy alone was less effective and should be only used in non‐operable patients. Radiotherapy after surgery as a rescue method might not act effectively, while preoperative radiotherapy was associated with good clinical response and should be recommended. J. Surg. Oncol. 2007;96:19–25. © 2007 Wiley‐Liss, Inc.
Occult pancreaticobiliary reflux in gallbladder cancer and benign gallbladder diseases
Authors: Beltrán Marcelo A. , Vracko Jozef , Cumsille Miguel A. , Cruces Karina S. , Almonacid Jorge , Danilova Tatiana 
Published: March 2007

AbstractBackground and ObjectivesIt was proposed that occult pancreaticobiliary reflux (OPBR) was associated with precancerous mucosal changes in the gallbladder, hence the importance of this disorder. There are no published reports investigating the incidence of OPBR in patients operated on for the entire spectrum of benign gallbladder diseases and gallbladder cancer. Our aim was to determine the incidence of OPBR and measure the levels of active pancreatic enzymes (amylase and lipase) in gallbladder bile of patients undergoing cholecystectomy for benign and malignant gallbladder diseases.MethodsOne hundred eight patients with normal pancreaticobiliary junction evidenced by operative cholangiography were included in the study.ResultsAccording to gallbladder bile amylase and lipase levels, 84.2% and 89% patients respectively had OPBR. OPBR was present in all gallbladder cancer patients; in these patients the biliary levels of amylase and lipase were significantly higher than the levels found in patients with benign gallbladder pathology (P < 0.0001).ConclusionsOPBR could lead to inflammatory changes of the biliary epithelium and progress towards the development of precancerous mucosal changes and gallbladder cancer. The reason why such high levels of pancreatic enzymes are regurgitated into the biliary tree of patients with gallbladder cancer should be clarified. J. Surg. Oncol. 2007;96:26–31. © 2007 Wiley‐Liss, Inc.
Resection and reconstruction of retrohepatic vena cava without venous graft during major hepatectomies
Authors: Machado Marcel Autran C. , Herman Paulo , Bacchella Telesforo , Machado Marcel C.C. 
Published: March 2007

AbstractBackgroundProgress in liver surgery has enabled hepatectomy with concomitant venous resection for liver malignancies involving the inferior vena cava (IVC). The authors describe an alternative technique for IVC reconstruction without the need of graft.MethodsParenchymal transection is performed from anterior surface of the liver down to the anterior or left lateral surface of the IVC using combination of two techniques reported elsewhere. IVC is clamped above and below the tumor and the liver in continuity with an invaded segment of IVC is removed en bloc. A transverse anastomosis of IVC is performed starting with running suture on the posterior wall followed by the anterior wall.ResultsThis approach has been successfully employed in eight consecutive patients with IVC involvement. The procedures performed were 5 right hepatectomies, 1 right posterior sectionectomy, 1 right trisectionectomy, and 1 left trisectionectomy. Two patients needed total vascular exclusion (TVE) for 11 and 10 min, respectively. Blood transfusion was necessary in three patients. Pathologic surgical margins were free in all cases. No postoperative mortality was observed.ConclusionThis technique of IVC reconstruction precludes the use of graft and minimizes the use of TVE decreasing ischemic damage to the remnant liver. J. Surg. Oncol. 2007;96:73–76. © 2007 Wiley‐Liss, Inc.
Rehabilitation of surgical cancer patients at University of Texas M. D. Anderson Cancer Center
Authors: Yadav Rajesh 
Published: March 2007

AbstractWith early detection and treatment, survival rates for many types of cancer have improved. Long term survivors have number of issues, which can include functional deficits, pain, fatigue, lymphedema and altered bowel and bladder function. Simple activities such as mobility and the ability to perform self care can be limited. In addition, re‐integration into society with activities such as driving, social interaction and return to work are often problematic. The goal of cancer rehabilitation is to improve quality of life by minimizing disability and handicap caused by cancer and associated treatments. Initial rehabilitation interventions usually occur in an inpatient setting as patients often experience a decline in functional status due to cancer progression and or surgical treatment. Rehabilitation interventions reduce the debility and functional deficits and add to the quality of life for cancer patients undergoing surgical treatments. The rehabilitation team can assist not only with acute decline in functional status but also with re‐integration back in society. Both general and specific rehabilitation interventions based on diagnoses are reviewed. J. Surg. Oncol. 95:361–369. © 2007 Wiley‐Liss, Inc.
Factors affecting burnout and compassion fatigue in psychotherapists treating torture survivors: Is the therapist's attitude to working through trauma relevant?
Authors: Deighton Russell McKenzie , Gurris Norbert , Traue Harald 
Published: March 2007

AbstractIn this study, a group of trauma therapists (N = 100) working with torture survivors was investigated with respect to the extent to which they advocated and practiced working through traumatic events as well as levels of symptomatology including compassion fatigue, burnout, and distress. Results showed that a combination of high advocacy and low degree of working through traumatic events was related to high symptomatology. Therapists with this combination showed more compassion fatigue, burnout, and distress than therapists who advocated and practiced working through traumatic events, as well as therapists who neither advocated nor practiced it. Results are discussed with respect to the pathogenic role of fear avoidance in therapists.
Use of mental health treatment among veterans filing claims for posttraumatic stress disorder
Authors: Sayer Nina A. , Clothier Barbara , Spoont Michele , Nelson David B. 
Published: March 2007

AbstractThis study examines predictors of current mental health service use in a sample of 154 veterans filing claims for Veterans Affairs (VA) disability benefits based on Posttraumatic Stress Disorder (PTSD). Our conceptual framework was the behavioral model that classifies predictors of service utilization into predisposing (background), enabling (e.g., insurance) and need (e.g., symptoms) factors. Slightly more than half of the PTSD claimants were receiving mental health treatment at the time of claim initiation. Mean symptom levels were clinically significant in both users and nonusers of mental health treatment. In a multivariate logistic regression analysis, mental health treatment use was associated with younger age, marriage, and dependence on public insurance. Implications for future research are discussed.
Copolymerization of n‐butylacrylate with methylmethacrylate by a novel photoinitiator, 1‐(bromoacetyl)pyrene
Authors: Mishra Anuradha , Daswal Swati 
Published: March 2007

AbstractThe photopolymerization efficiency of pyrene (Py), 1‐acetylpyrene (AP), and 1‐(bromoacetyl)pyrene (BP) for copolymerization of n‐butylacrylate (BA) with methylmethacrylate (MMA) was compared. A kinetic study of solution copolymerization in DMSO at 30 ± 0.2°C showed that the Py could not initiate copolymerization even after 20 h, whereas with AP as initiator, less than 1% conversion was observed. However, introduction of a Br in α‐methyl group of AP significantly enhanced the percent conversion. The kinetics and mechanism of copolymerization of BA with MMA using BP as photoinitiator have been studied in detail. The system follows nonideal kinetics (Rp α [BP]0.67[BA]1[MMA]0.98), and degradative solvent transfer reasonably explains these kinetic nonidealities. The monomer reactivity ratios (MRRs) of MMA and BA have been estimated by the Finemann–Ross and Kelen–Tudos methods, by analyzing copolymer compositions determined by 1H‐NMR spectra. The values of r1 (MMA) and r2 (BA) were found to be 2.17 and 0.44, respectively, which suggested the high concentration of alternating sequences in the random copolymers obtained. © 2007 Wiley Periodicals, Inc. Int J Chem Kinet 39: 261–267, 2007
Experimental and theoretical study of the homogeneous, unimolecular gas‐phase elimination kinetics of 2‐furoic acid
Authors: Ramírez Beatriz C. , Domínguez Rosa M. , Herize Armando , Tosta María , Cordova Tania , Chuchani Gabriel 
Published: March 2007

AbstractThe kinetics of the gas‐phase elimination kinetics of CO2 from furoic acid was determined in a static system over the temperature range 415–455°C and pressure range 20–50 Torr. The products are furan and carbon dioxide. The reaction, which is carried out in vessels seasoned with allyl bromide and in the presence of the free‐radical suppressor toluene and/or propene, is homogeneous, unimolecular, and follows a first‐order rate law. The observed rate coefficient is expressed by the following Arrhenius equation: log k1(s−1) = (13.28 ± 0.16) − (220.5 ± 2.1) kJ mol−1 (2.303 RT)−1. Theoretical studies carried out at the B3LYP/6‐31++G** computational level suggest two possible mechanisms according to the kinetics and thermodynamic parameters calculated compared with experimental values. © 2007 Wiley Periodicals, Inc. Int J Chem Kinet 39: 298–306, 2007
Solvent and substituent effects on the electrochemical oxidation of para‐ and meta‐substituted anilines
Authors: Bhuvaneshwari D. S. , Elango K. P. 
Published: March 2007

AbstractElectrochemical oxidation of 15 para‐ and meta‐substituted anilines in different mole fractions of water in 2‐methylpropan‐2‐ol has been investigated in the presence of 0.1 M sulfuric acid as a supporting electrolyte. The oxidation potential data of anilines correlate well with the Brown–Okamoto's substituent constants affording a negative reaction constant. The effect of para‐ and meta‐substituents on the oxidation potential confirms to Swain's F and R, affording negative reaction constants. The oxidation potential values also correlate satisfactorily with macroscopic solvent parameter such as relative permittivity, εr. The results of Kamlet–Taft multiple correlation analysis show that specific solute–solvent interactions play a dominant role in governing the reactivity. © 2007 Wiley Periodicals, Inc. Int J Chem Kinet 39: 289–297, 2007
Alternative denervation using laser irradiation in lumbar facet syndrome
Authors: Iwatsuki Koichi , Yoshimine Toshiki , Awazu Kunio 
Published: March 2007

AbstractBackground and ObjectiveFacet syndrome is persistent low back pain that might be treated with some surgical interventions. The target of surgical techniques is the transverse process bases where the medial nerve branches innervated the facet. However, highly variable success rates have been demonstrated in different series.Study Design/Materials and MethodsWe carried out laser denervation to the dorsal surface of the facet capsule, where it is richly innervated with medial nerve branches.ResultsOne year after laser denervation, 17 patients (81%) experienced complete or greater than 70% pain reduction in all 21 patients. Among the six patients who had previously undergone spinal surgery, two (33.3%) experienced successful pain relief. Overall, in four patients (19%), the response to laser denervation at 1‐year follow‐ups was not successful.ConclusionThe dorsal surface of the facet capsule might be a more preferable target for facet denervation. Lasers Surg. Med. 39:225–229, 2007. © 2007 Wiley‐Liss, Inc.
PRKCG mutation (SCA‐14) causing a Ramsay Hunt phenotype
Authors: Visser Jasper E. , Bloem Bastiaan R. , van de Warrenburg Bart P. C. 
Published: March 2007

AbstractProgressive myoclonic ataxia, also referred to as Ramsay Hunt syndrome, is characterized by a combination of myoclonus and cerebellar ataxia, infrequently accompanied by tonic–clonic seizures. Its differential diagnosis overlaps with progressive myoclonic epilepsy, a syndrome with myoclonus, tonic–clonic seizures, progressive ataxia and dementia. In patients with progressive myoclonic epilepsy, specific diseases can frequently be recognized, but the diagnostic yield in progressive myoclonic ataxia is much lower. We describe a patient who presented with multifocal myoclonus in his thirties and who later developed cerebellar ataxia and focal dystonia. His father was similarly affected. Genetic studies revealed a mutation in the protein kinase C gamma (PRKCG) gene, known to cause spinocerebellar ataxia type 14 (SCA‐14). This case illustrates that both myoclonus and dystonia are part of the clinical spectrum in SCA‐14 and that myoclonus can even be the presenting symptom. We suggest that SCA‐14 should be considered in the differential diagnosis of progressive myoclonic ataxia. © 2007 Movement Disorder Society
Primary skeletal muscle involvement in chorea‐acanthocytosis
Authors: Saiki Shinji , Sakai Koichiro , Murata Ken‐Ya , Saiki Misuzu , Nakanishi Megumi , Kitagawa Yoko , Kaito Muichi , Gondo Yuichiro , Kumamoto Toshihide , Matsui Makoto , Hattori Nobutaka , Hirose Genjiro 
Published: March 2007

AbstractChorea‐acanthocytosis (ChAc) is a hereditary disease characterized by involuntary movements and amyotrophy with elevation of serum creatine kinase. Although skeletal muscle involvement in ChAc has been suggested, the mechanism remains unclear. To investigate chorein abnormalities of the skeletal muscles of ChAc patients with an apparently heterozygous VPS13A mutation compared with those of other hereditary choreic diseases, we performed histological and immunohistochemical studies of the skeletal muscles from 3 ChAc, 1 Huntington's disease (HD), 1 McLeod syndrome (MLS), and 1 normal control (NC) with 2 originally generated anti‐chorein antibodies. Chorein immunoreactivities in HD, MLS, and NC were found linearly along the sarcolemma and appeared as speckles in the sarcoplasma, but those in ChAc were uneven and discontinuous along the sarcolemmas and increased in the sarcoplasma especially in type I fibers. This histological observation suggests chorein abnormalities of skeletal muscles might be associated with primary involvement of skeletal muscles in this disorder. © 2007 Movement Disorder Society
High performance liquid chromatographic analysis of iridoid glycosides from Penstemon rydbergii varieties
Authors: Arslanian Robert L. , Stermitz Frank R. 
Published: March 2007

AbstractA new reversed phase high‐performance liquid chromatographic method was used to quantify iridoid content in plant extracts. Two varieties of Penstemon rydbergii from different locations in the Western United States were found to contain the iridoid glycosides euphroside, aucubin, geniposidic acid and plantarenaloside together with the phenylpropanoid glycoside verbascoside. While one variety showed a tenfold dominance of plantarenaloside over euphroside, the reverse was true of the other variety. The previously reported new iridoid glycoside pinifolin was shown to be an artefact from plantarenaloside since it could be isolated from a boiled extract, but not from a cold extract.
An improved high performance liquid chromatographic post‐column derivatization procedure for the UV — Vis spectroscopic characterization of phenolic compounds
Authors: Mueller‐Harvey I. , Blackwell P. M. S. 
Published: March 2007

AbstractAn improved method is described for the characterization of phenolic compounds using post‐column shift reagents following their separation by high performance liquid chromatography (HPLC). Modifications include the use of NaOH to adjust the pH of the column effluent, prior to introducing the AICI3 and H3BO3 reagents, and the use of commercially available spin chambers for efficiently mixing the effluent with the reagents, resulting in a negligible loss of resolution. Shifts obtained by the HPLC post‐column derivatization and the conventional procedure are comparable.
Multidimensional gas chromatography/mass spectrometry: A powerful tool for the direct chiral evaluation of aroma compounds in plant tissues I. 5‐alkanolides in fruits
Authors: Bernreuther Alexander , Bank Jürgen , Krammer Gerhard , Schreier Peter 
Published: March 2007

AbstractOn‐line coupled multidimensional gas chromatography (DB‐5/Lipodex D)/mass spectrometry was used for direct chiral evaluation of δ‐hexa‐, δ‐octa‐, δ‐deca‐ and, in part, δ‐dodecalactone in various fruits. Whereas in raspberry the (S)‐enantiomers predominated [enantiomeric excess (ee) values from 45.0 to 100%], the (R)‐enantimomers prevailed in apricot, coconut, greengage, mango, pineapple, plum and yellow plum (ee values from 14.4 to 100%). Variations between (S)‐ and (R)‐enantiomers depending on chain length were found in red and yellow passion fruit, peach and strawberry. δ‐Hexalactone in greengage and pineapple as well as δ‐dodecalactone in coconut were found to occur in these fruits in approximately racemic form [ee values 10.8% (R) and 4.4% (R) as well as 5.2% (R), respectively].
Quantitative characterization of the contents of Papaver somniferum latex vacuoles
Authors: Pham Thid. T. , Roberts Margaret F. 
Published: March 2007

AbstractPapaver somniferum latex vacuoles were separated into two discrete fractions–‐the 900 Xg and the 1100 Xg vacuoles. The two vacuolar populations were assayed over the three‐week period of capsule maturation. Estimations of the anions sulphate, meconate and chloride, as well as the inorganic cations K+,Na+, Mg2+ and Ca2+, were made, together with measurements of the alkaloids morphine, codeine, thebaine, papaverine and noscapine. A correlation between alkaloids and organic acids has been established which supports the proposed “ion trap” mechanism proposed for alkaloid sequestration in poppy latex vacuoles.
High performance liquid chromatography and nuclear magnetic resonance analysis of longipinene derivatives from Stevia subpubescens var. intermedia
Authors: Joseph‐Nathan Pedro , Cerda‐García‐Rojas Carlos M. , Castrejón Salmantina , Román Luisa U. , Hernández Juan D. 
Published: March 2007

AbstractThe methodology for the separation of complex mixtures of longipin‐2‐ene‐7β, 9α‐diol‐1‐one diesters using high performance liquid chromatography followed by the identification of individual components by pulse Fourier transform 1H nuclear magnetic resonance spectroscopy is described. The identification methodology takes advantage of the spectral comparison between the isolated natural product and a wide series of previously prepared longipinene derivatives, and is applied to the study of the extracts of Stevia subpubescens var. intermedia which contain 11 previously isolated longipinene diesters and the new natural product longipin‐2‐ene‐7β, 9α‐diol‐1‐one 7‐seneciate‐9‐angelate.
Analysis of cytochalasins in cultures of Ascochyta spp. and in infected plants by high performance liquid and thin layer chromatography
Authors: Capasso Renato , Evidente Antonio , Randazzo Giacomino , Vurro Maurizio , Bottalico Antonio 
Published: March 2007

AbstractHigh performance liquid chromatography and high performance thin layer chromatography were used in combination to check the occurrence of the bioactive cytochalasins A, B, C, D, E, H and J in cultures of some phytopathogenic species of Ascochyta, isolated from infected plants. Cytochalasins A and B were readily detected and estimated in the culture filtrates of Ascochyta heteromorpha Sch. and Sacc., the causal agent of foliar disease of oleander (Nerium oleander L.). The two compounds were also detected in oleander leaves naturally infected by A. heteromorpha suggesting that these compounds play a role in the disease of the ornamental plant. None of the above mentioned cytochalasins were detected in the culture filtrates of the other fungi tested.
Analysis of alkaloids in Chinese Ephedra species by gas chromatographic methods
Authors: Cui Jian‐Fang , Zhou Tong‐Hui , Zhang Jian‐Sheng , Lou Zhi‐Cen 
Published: March 2007

AbstractThe six Ephedra alkaloids (ephedrine, norephedrine, pseudoephedrine, norpseudoephedrine, methylephedrine and methylpseudoephedrine) in 12 species of Chinese Ephedra collected in 16 districts of China were separated and identified by gas chromatography combined with mass spectrometry following trimethylsilylation of the extract. The alkaloidal concentrations were determined using a gas chromatograph equipped with a nitrogen phosphorus detector. The methods described are sensitive, accurate and simple to perform.