bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac autonomic dysfunction and structural remodeling: the potential mechanism to mediate the relationship between obstructive sleep apnea and cardiac arrhythmias
Authors: Chen Hao , Zhang Qingfeng , Hao Yueying , Zhang Jingyi , He Yang , Hu Ke 
Published: April 2024

BackgroundCardiac arrhythmias are very common in patients with obstructive sleep apnea (OSA), especially atrial fibrillation (AF) and nonsustained ventricular tachycardia (NVST). Cardiac autonomic dysfunction and structural remodeling caused by OSA provide the milieu for cardiac arrhythmia development. This study aimed to determine whether OSA is associated with various cardiac arrhythmias and investigate potential pathophysiologic pathways between them.MethodsThe analysis covered 600 patients with clinical suspicion of OSA hospitalized in Renmin Hospital of Wuhan University between January 2020 and May 2023. After undergoing sleep apnea monitor, all subjects received laboratory tests, Holter electrocardiography, and Echocardiography.ResultsCompared with those without OSA and adjusting for potential confounders, subjects with moderate OSA had three times the odds of AF (odds ratio [OR] 3.055; 95% confidence interval [CI], 1.002–9.316; p = 0.048). Subjects with severe OSA had three times the odds of AF (OR 3.881; 95% CI, 1.306–11.534; p = 0.015) and NSVT (OR 3.690; 95% CI, 0.809–16.036; p = 0.046). There were significant linear trends for the association between OSA severity with AF and NVST (p &lt; 0.05). And this association was mediated by cardiac structural changes including left atrial diameter, left ventricular diastolic diameter, right atrial diameter and right ventricular diameter. In addition, the ratio of low-frequency and high-frequency individually mediated the association between severe OSA and NVST.ConclusionThis study demonstrated that severe OSA was independently associated with AF and NSVT, and this association was mediated by autonomic nervous system changes and cardiac structural remodeling.
Long-term surgical outcomes of bile duct tumor thrombus versus portal vein tumor thrombus for hepatocellular carcinoma: a propensity score matching analysis
Authors: Li Yi-Nan , Wei Shao-Ming , Fu Yang-Kai , Zeng Zhen-Xin , Huang Li-Ming , Lv Jia-Hui , Chen Wei-Zhao , Wei Yong-Gang , Zhang Zhi-Bo , Zhou Jian-Yin , Wu Jia-Yi , Yan Mao-Lin 
Published: April 2024

BackgroundPortal vein tumor thrombus (PVTT) seriously affects the prognosis of hepatocellular carcinoma (HCC). However, whether bile duct tumor thrombus (BDTT) significantly affects the prognosis of HCC as much as PVTT remains unclear. We aimed to compare the long-term surgical outcomes of HCC with macroscopic PVTT (macro-PVTT) and macroscopic BDTT (macro-BDTT).MethodsThe data of HCC patients with macro-BDTT or macro-PVTT who underwent hemihepatectomy were retrospectively reviewed. A propensity score matching (PSM) analysis was performed to reduce the baseline imbalance. The recurrence-free survival (RFS) and overall survival (OS) rates were compared between the cohorts.ResultsBefore PSM, the PVTT group had worse RFS and OS rates than the BDTT group (P = 0.043 and P = 0.008, respectively). Multivariate analyses identified PVTT (hazard ratio [HR] = 1.835, P = 0.016) and large HCC (HR = 1.553, P = 0.039) as independent risk factors for poor OS and RFS, respectively. After PSM, the PVTT group had worse RFS and OS rates than the BDTT group (P = 0.037 and P = 0.004, respectively). The 3- and 5-year OS rates were significantly higher in the BDTT group (59.5% and 52.1%, respectively) than in the PVTT group (33.3% and 20.2%, respectively).ConclusionAggressive hemihepatectomy provides an acceptable prognosis for HCC patients with macro-BDTT. Furthermore, the long-term surgical outcomes of HCC patients with macro-BDTT were significantly better than those of HCC patients with macro-PVTT.
A new custom-made bivalve brace for pectus carinatum in children and adolescents: preliminary promising experience of 140 patients from a tertiary center
Authors: Frediani Simone , Zarfati Angelo , Pardi Valerio , Aloi Ivan , Bertocchini Arianna , Accinni Antonella , Beati Federico , Pasanisi Massimiliano , Inserra Alessandro 
Published: April 2024

IntroductionInternational research suggests that poor patient compliance is the main cause of tutor failures in the context of potential novel orthopedic bivalve braces for conservative treatment of pectus carinatum. Our entire experimental study is based on the hypothesis that a rigid bivalve brace that patients can accept could solve the main problem associated with the conservative approach—poor compliance. The hypothesis was to reduce the thickness and weight of the classic bivalve brace to ensure concealment and make it sustainable enough to be worn several hours a day without compromising its therapeutic efficacy.Materials and methodThe research was conducted from January 2020 to December 2022 to ensure follow-up of all participants for at least 6 months. In 36 months, 140 patients with pectus carinatum were assessed and conservatively treated with the studied guardian to analyze the therapeutic efficacy of the bivalve brace and patient compliance. From the initial visit, the parents and patient were informed that this is a 2-year therapeutic course during which the bivalve brace should be worn at least 23 h a day (with 1 h of abstinence per day for routine personal hygiene practices). Compliance is the key to therapy success, and the duration of treatment depends on patient adherence.ResultsThe exceptional effectiveness of the experimental brace was confirmed by both the questionnaire from the patients (with an average satisfaction rate of 8.9/10) and an assessment of the therapy's results by a properly selected medical committee (with a VAS scale satisfaction of 7.2/10 for symmetric forms and 7.1/10 for asymmetric ones).ConclusionIn conclusion, the analyzed data confirmed the research hypotheses. First, none of the 140 patients had cardiovascular diseases directly related to their condition, confirming that pectus carinatum is a pathology of a purely aesthetic nature. Second, a cheap, lightweight, and easily obscured brace significantly improved patient compliance. Along with this, the social relevance of the aesthetic aspect today may be an important factor in motivating the study cohort to adhere to therapy. In the past, esthetics and appearance were less relevant at the social level, which may have contributed to the high abandonment and reduced compliance rates of the many studies in the literature.
Drug-drug interactions with oral anticoagulants: information consistency assessment of three commonly used online drug interactions databases in Switzerland
Authors: Coumau Claire , Gaspar Frederic , Terrier Jean , Schulthess-Lisibach Angela , Lutters Monika , Le Pogam Marie-Annick , Csajka Chantal 
Published: April 2024

Background: Toxicity or treatment failure related to drug-drug interactions (DDIs) are known to significantly affect morbidity and hospitalization rates. Despite the availability of numerous databases for DDIs identification and management, their information often differs. Oral anticoagulants are deemed at risk of DDIs and a leading cause of adverse drug events, most of which being preventable. Although many databases include DDIs involving anticoagulants, none are specialized in them.Aim and method: This study aims to compare the DDIs information content of four direct oral anticoagulants and two vitamin K antagonists in three major DDI databases used in Switzerland: Lexi-Interact, Pharmavista, and MediQ. It evaluates the consistency of DDIs information in terms of differences in severity rating systems, mechanism of interaction, extraction and documentation processes and transparency.Results: This study revealed 2’496 DDIs for the six anticoagulants, with discrepant risk classifications. Only 13.2% of DDIs were common to all three databases. Overall concordance in risk classification (high, moderate, and low risk) was slight (Fleiss’ kappa = 0.131), while high-risk DDIs demonstrated a fair agreement (Fleiss’ kappa = 0.398). The nature and the mechanism of the DDIs were more consistent across databases. Qualitative assessments highlighted differences in the documentation process and transparency, and similarities for availability of risk classification and references.Discussion: This study highlights the discrepancies between three commonly used DDI databases and the inconsistency in how terminology is standardised and incorporated when classifying these DDIs. It also highlights the need for the creation of specialised tools for anticoagulant-related interactions.
Cinnamaldehyde attenuates streptozocin-induced diabetic osteoporosis in a rat model by modulating netrin-1/DCC-UNC5B signal transduction
Authors: Ji Songjie , Zhao Bingjia , Gao Yuan , Xie Jun , Han Huijun , Wu Qunli , Yang Dan 
Published: April 2024

Background: Cinnamaldehyde (CMD) is a major functional component of Cinnamomum verum and has shown treatment effects against diverse bone diseases. This study aimed to assess the anti-diabetic osteoporosis (DOP) potential of diabetes mellitus (DM) and to explore the underlying mechanism driving the activity of CMD.Methods: A DOP model was induced via an intraperitoneal injection of streptozocin (STZ) into Sprague–Dawley rats, and then two different doses of CMD were administered to the rats. The effects of CMD on the strength, remodeling activity, and histological structure of the bones were assessed. Changes in the netrin-1 related pathways also were detected to elucidate the mechanism of the anti-DOP activity by CMD.Results: CMD had no significant effect on the body weight or blood glucose level of the model rats. However, the data showed that CMD improved the bone strength and bone remodeling activity as well as attenuating the bone structure destruction in the DOP rats in a dose-dependent manner. The expression of netrin-1, DCC, UNC5B, RANKL, and OPG was suppressed, while the expression of TGF-β1, cathepsin K, TRAP, and RANK was induced by the STZ injection. CMD administration restored the expression of all of these indicators at both the mRNA and protein levels, indicating that the osteoclast activity was inhibited by CMD.Conclusion: The current study demonstrated that CMD effectively attenuated bone impairments associated with DM in a STZ-induced DOP rat model, and the anti-DOP effects of CMD were associated with the modulation of netrin-1/DCC/UNC5B signal transduction.
Understanding South Korean women workers’ career transition experiences: using the career decision tree model
Authors: Kim Namhee , Kim Kyung Nam , Baek Pyounggu 
Published: April 2024

IntroductionRelatively little research has explored non-Western women workers and their career transitions within their unique cultural contexts. Thus, more context-sensitive approaches to women’s career trajectories are needed.MethodsBased on Bian and Wang’s Career Decision Tree Model (2019) as a conceptual framework, the reasons for South Korean women workers’ career transitions and influencing factors were explored using a qualitative approach with in-depth interviews with 35 South Korean women workers at various career stages.Results and DiscussionTheir main motive of career transitions was difficulty maintaining their physical and mental health, which stemmed from their demanding work life. A typical issue, the burden of child rearing and family responsibilities, was also reported, but it was not the primary reason for their career transitions. Instead, the women workers often mentioned these responsibilities along with other reasons. Other reasons were unresolved career interests and expectations associated with their lack of career goals and preparation prior to joining the labor market. These factors led to significant changes in women’s values and priorities along their career path, which finally triggered a decision to make a career transition. South Korean socio-cultural characteristics embedded in the South Korean women’s personal and organizational lives provide insights on how to interpret the findings. Although on the surface some of our findings appeared to confirm previous studies on women’s career transitions in Western-based literature, noteworthy differences were discovered when delving deeper into women’s career transitions in the South Korean context.
Eriobotrya japonica Fermentation with Plant-Derived Lactiplantibacillus plantarum MSC-5T Ameliorates Antioxidant Activity in HEK293 Cells
Authors: Danshiitsoodol Narandalai , Inoue Yusuke , Sugimoto Sachiko , Shakya Shrijana , Noda Masafumi , Sugiyama Masanori 
Published: April 2024

Oxidative stress from an excess of radical compounds generally impacts apoptosis and inflammation. The use of probiotics, therefore, has emerged as a favorable tool to suppress the formation of reactive oxygen species. In the present study, we investigated the antioxidant activity of plant-derived Lactiplantibacillus (L.) plantarum MSC-5T fermented in Eriobotrya japonica (EJ) aqueous extract. In the in vitro study, the extract fermented with the MSC-5T strain markedly decreased the cell death of H2O2-induced HEK293 cells. In addition, the fermented extract showed a protective effect against fungal toxin ochratoxin A (OTA) and citrinin (CTN). Regarding the evaluation of glutathione homeostasis, it can be clearly seen that pretreatment of HEK293 cells with fermented EJ extract greatly increased glutathione (GSH) levels, while unfermented extract did not affect the cellular GSH content. Furthermore, we identified a bioactive compound as pyrocatechol, which displayed significant antioxidation activity. The extract fermented for 48 h with the MSC-5T strain in EJ extract produces 167.4 μg/mL pyrocatechol.
Poglądy antyfederalistów na kształt Unii w czasie Konwencji Filadelfijskiej i procesu ratyfikacji Konstytucji Stanów Zjednoczonych
Authors: Tulejski Tomasz 
Published: April 2024

CEL NAUKOWY: Celem artykułu jest przedstawienie głównych argumentów antyfederalistycznych przeciwko Konstytucji Stanów Zjednoczonych.
PROBLEM I METODY BADAWCZE: Antyfederalizm był ruchem politycznym końca XVIII wieku, który sprzeciwiał się utworzeniu silniejszego rządu federalnego Stanów Zjednoczonych i który później sprzeciwił się ratyfikacji Konstytucji z 1787 roku. W tym artykule zadano następujące pytania: Dlaczego antyfederaliści sprzeciwiali się Konstytucji Stanów Zjednoczonych? ­Dlaczego nowy rząd był zbyt silny? Dlaczego silniejszy rząd zagrażał suwerenności i wolności stanów, społeczności lokalnych lub jednostek?
PROCES WYWODU: Dokonano krytycznej analizy tekstu Konstytucji Stanów Zjednoczonych, dokumentów federalistów i antyfederalistów oraz najważniejszych argumentów w wielkiej debacie konstytucyjnej.
WYNIKI ANALIZY NAUKOWEJ: Krytyka Konstytucji Stanów Zjednoczonych przez antyfederalistów wynikała z obaw przed skonsolidowanym rządem federalnym. Jej główne elementy po ratyfikacji stały się narzędziem obrony praw stanów i zasad federalizmu zdefiniowanych podczas debat w Filadelfii i na konwencjach stanowych.
WNIOSKI, INNOWACJE, REKOMENDACJE: Opracowanie pozwala na sformułowanie wniosku, że federaliści stworzyli Konstytucję USA, ale antyfederaliści od początku ją przejęli. To napięcie między federalistami i antyfederalistami trwa w całej historii Stanów Zjednoczonych aż do dnia dzisiejszego.
Soft skills among academics: Five theoretically informed lessons for current times
Authors: Szulc Joanna Maria , Toporek Magdalena , Tomczak Michał Tomasz , Gawrycka Małgorzata 
Published: April 2024

RESEARCH OBJECTIVE: The aim of this article is to provide a comprehensive examination of the role of soft skills among academics in the context of the evolving higher-education landscape.
THE RESEARCH PROBLEM AND METHODS: We use a scoping review of existing literature to discuss the importance of soft skills in academia. Through critical analysis and synthesis, we identify patterns and gaps in current knowledge and develop five theoretically informed lessons to improve practice and theory.
THE PROCESS OF ARGUMENTATION: A unique theoretical blending of five theories (resource-based, dynamic capabilities, cultural learning, implicit leadership, and human capital) forms the conceptual framework we used to arrive at our conclusions.
RESEARCH RESULTS: Our first conclusion emphasizes that soft skills are essential for a competitive advantage in the performative culture of neoliberal academies. Second, we emphasize that updating soft skills is crucial in order to respond to the changing higher-education environment. Third, going beyond the universal view of academia as a sharply hierarchical industry, we demonstrate how building relationships with stakeholders is necessary for academic skill development. Our fourth lesson explores the implications of different evaluators’ perceptions of soft skills, highlighting the need for recognition of their value. The ultimate lesson highlights the need to invest in the skills of academics.
CONCLUSIONS, INNOVATIONS, AND RECOMMENDATIONS: We consolidate existing theoretical approaches and overcome theoretical fragmentation to arrive at a comprehensive and theoretically grounded set of lessons for those interested in developing and utilizing soft skills among academics in the unique context of the ever-changing higher-education environment. We challenge the norms of neoliberal academia and call for the development of realistic policies and procedures that promote a respectful, collaborative, and sustainable higher-education environment.
Konstytucyjna wolność zrzeszania się jako gwarancja realizacji potrzeb politycznych jednostki
Authors: Kijańska Klaudia 
Published: April 2024

CEL NAUKOWY: Zasadniczym celem naukowym artykułu jest poddanie analizie znaczenia wolności zrzeszania się, tj. art. 58 Konstytucji RP jako formy realizacji potrzeb politycznych człowieka. Praca ma ustalić, czy obecnie obowiązujące rozwiązania w zakresie zrzeszania się gwarantują realną możliwość zadośćuczynienia potrzebom ludzkim, a wynikającym z ich natury.
PROBLEM I METODY BADAWCZE: Podstawowym problemem badawczym jest ustalenie, czy obecne gwarancje wolnościowe, dotyczące swobody zrzeszania się, stanowią formę realizacji potrzeb politycznych człowieka. Do przeprowadzenia analizy zastosowano metody z zakresu nauk prawnych, tj. analizę dogmatyczno-prawną, doktrynalną, jak i teoretyczno-prawną.
PROCES WYWODU: W pierwszej części artykułu zajęto się przedstawieniem znaczenia czynnika społecznego w zakresie funkcjonowania państwa. Odwołano się do społecznej natury człowieka, opierając się na arystotelesowskim ujęciu politikon zoon. Kolejno przeprowadzono analizę regulacji ustawy zasadniczej w kontekście oddziaływania jednostki na sferę aktywności władzy za pośrednictwem wolności zrzeszania się. Końcowa część artykułu stanowi odpowiedź na założenia odnośnie do roli swobody stowarzyszania się w życiu każdego człowieka.
WYNIKI ANALIZY NAUKOWEJ: Wolność zrzeszania się stanowi istotny element realizacji potrzeb ludzkich wynikających z natury społecznej człowieka, będąc formą oddziaływania politycznego. Obowiązujące regulacje konstytucyjne w odniesieniu do wolności zrzeszania się stanowią płaszczyznę umożliwiającą realny wpływ jednostki na władzę.
WNIOSKI, INNOWACJE, REKOMENDACJE: Wobec źródła wolności zrzeszania się, jakim jest godność człowieka, zachodzi konieczność wdrożenia przez państwo takich standardów, które umożliwią realizację tej swobody bez względu na różne uwarunkowania prawne znajdujące się po stronie jednostki. Możliwość realizacji tej wolności powinna wyznaczać standardy w kształtowaniu prawa w obszarze stowarzyszania się.
Annealing temperature dependence of magnetic properties in FeCo ordered alloy thin films fabricated using the nitrogen surfactant effect
Authors: Umeda Y. , Ono H. , Yamamoto K. , Ishiyama O. , Iwayama H. , Nakamura E. , Yokoyama T. , Mizuguchi M. , Miyamachi T. 
Published: April 2024

Abstract
L10-FeCo has attracted attention as a new, rare-metal-free magnetic material due to its large uniaxial magnetic anisotropy. However, the low stability of the L10 phase hampers its practical application. We here intend to prepare FeCo alloy thin films by utilizing the nitrogen surfactant effect. The enhancement of the out-of-plane magnetization of this thin film was observed by stacking cobalt single atomic layer on bilayer iron nitride and subsequent annealing at 470 K. This study provides an insight into the relationship between structural changes and magnetic properties of the FeCo interface on the atomic scale, and paves the way for the development of rare metal-free magnetic materials.
Efisiensi Alokatif Penggunaan Faktor-Faktor Produksi Pada Budidaya Ikan Nila di Kecamatan Mempawah Timur Kabupaten Mempawah
Authors: Lestari Vivi Ayu , Adi Suyatno  , Shenny Oktoriana  
Published: April 2024

Tujuan dari penelitian ini adalah untuk mengidentifikasi elemen-elemen yang memengaruhi produksi ikan nila dalam keramba dan tingkat efisiensi alokatif dalam penggunaan faktor-faktor produksi ikan nila di wilayah Kecamatan Mempawah Timur. Penelitian dilakukan di Kabupaten Mempawah Kecamatan Mempawah Timur dengan responden berjumlah 62 orang. Penelitian ini menggunakan metode analisis Faktor Produksi dengan menggunakan Uji Koefisien Determinasi, Uji F, dan Uji t. Selain itu, dilakukan analisis Efisiensi Alokatif dengan fokus pada efisiensi alokatif benih dan pakan. Dari hasil penelitian, dapat disimpulkan bahwa faktor produksi benih dan pakan memiliki pengaruh signifikan, sedangkan tenaga kerja dan keramba tidak memengaruhi produksi ikan nila dalam keramba. Analisis alokatif menunjukkan bahwa alokasi penggunaan benih dan pakan saat ini belum efisien, sehingga disarankan untuk menambah jumlah input tersebut.
Quality Assessment Radiotherapy Planning of Breast Cancer Patients with Built-In Metal Port Implants
Authors: Sannikova E. O. , Lebedenko I. М. , Kosenkova L. M. , Timoshkina E. V. 
Published: April 2024

Purpose: To evaluate the quality of radiation planning for breast cancer patients with implants with a built-in metal port. Conduct a quantitative analysis of the quality of planning, assess the dose load on critical organs for this category of patients.Material and methods: Homogeneity and conformity indices were calculated, and dose loads in critical organs were assessed for irradiation plans using 3D conformal RT (3D CRT) technology for 23 breast cancer patients with a built-in metal port implants. Calculations were carried out both taking into account (outlining) the metal port and artifacts from it on CT images, and without taking it into account.Results: Based on the results of the analysis of the calculated values of conformity and homogeneity indices, doses in critical organs of irradiation plans for 23 patients with breast cancer, it was shown that the presence of a metal port and artifacts from it affects the nature of the dose distribution.Conclusions: When creating a 3D CRT treatment plan, it is necessary to delineate the metal port and artifacts and assign true densities.