bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Review on Personalized Medicine: A Medical Treatment to The Individual Characteristics of Each Patient
Authors: Asif Mohammad , Pandey Anshuman , Khan Farheen Sanad , Rai Ayushi , Saqib Najmus , Alam Mr Qumre 
Published: March 2024

The idea of Personalized Medicine is not new – Doctors have long recognized that different patients react differently to medical interventions because the goal of medicine has always been to treat each patient as an individual. What is new is that paradigmatic advances in science and technology hold out from hope for the creation of targeted therapeutics and tools for determining who will benefit from a medical treatment and who will have negative side effects. Personalized Medicine has made significant advancements in recent years, demonstrating the capability of science to radically advance medical practice. Despite this, the problems of understanding human health and disease remain sobering. The intricate interplay of environmental, genetic, social, and cultural factors affects not just “Who We Are…” but also “What Disease We Are Prone To..” Fundamental advancements in our comprehension of each of these characteristics, as well as how they interact, will be necessary to realize a genuinely individualized approach to patient care. Personalized Medicine is something that concerns us all. Our unique viewpoints have an impact on how we interpret this area’s evolution. This section explains the idea of Personalized Medicine as well as various modern definitions and uses of the term
Nano Technology- A Comprehensive Review
Authors: Bharatia Rakesh , Kumar Sanjay , Yadav Vikas 
Published: March 2024

At the intersection of physical sciences, molecular engineering, biology, biotechnology, and medicine, recent research on nanoscale biosystems and nanotechnology has generated one of the most active science and technology sectors. Improved comprehension of living and thinking systems, ground-breaking biotechnology techniques, the creation of novel medications and their targeted administration, regenerative medicine, neuromorphic engineering, and the creation of a sustainable environment are all included in this field. Research on nano bio-systems is a top priority in many nations, and its importance to nanotechnology is predicted to rise in the coming years. The bioavailability of drugs is improved when their particle sizes are decreased to the sub-micron range since this increases the pace at which they dissolve significantly. The development of medication delivery employing nanoparticles (NPs) as carriers for tiny and big compounds has generated a lot of research attention. One of the most significant features of a medication delivery system is the ability to direct drug administration to sick areas. They have been utilized in-vivo to safeguard the drug entity in systemic circulation, limit drug access to the targeted locations, and deliver the drug to this site of action at a steady and controlled pace. For drug delivery studies, a variety of polymers have been employed to create nanoparticles that will boost therapeutic value while reducing side effects. The most noteworthy advancements in the use of nanotechnology as a medicine delivery mechanism are highlighted in this review article. Systems, techniques of preparation, applications, benefits, and drawbacks of pharmaceutical nanotechnology.
Exploration of Isatin as Anti-cancer and Anti-tubercular Modern Armamentarium. A Comprehensive Review on Isatin Congeners and its Promising Biological Activities
Authors: Gour Vivek Kumar , Gour Sadhna , Choudhary Akram , Noman MD , Yar M Shahar , Vats Nisha , Yahya Shaikh 
Published: March 2024

In recent eras, cancer, and tuberculosis have become the leading causes of not only morbidity but also mortality. Around 10 million cancer-related fatalities are reported annually worldwide, but 10.4 million new cases are also discovered each year. According to World Health Organization data, 10.4 million cases were in 2016 worldwide, whereas 360,565 cases in Indonesia was reported. Some clinically approved anticancer and anti-TB drugs demonstrate a most promising role in their treatment. Still, the need for new, powerful, and secure candidates as anticancer and Anti TB agents with a variety of modes of action is constantly present due to the serious growth of drug resistance, side effects, multidrug-resistant malignancies, and tuberculosis as a result of mutations. Over the last decade, various heterocyclic compounds in medicinal chemistry were explored and reported frequently in the literature; these derivatives have received substantial attention as anticancer and anti-TB agents. In which nitrogen-containing heterocyclic moiety, isatin emerged as a significant and versatile heterocyclic for developing novel anticancer and anti-TB candidates.
Future of Pharmaceutical Marketing in India-An Extensive Review
Authors: Asif Mohammad , Alam Mahtab , Alam Qumre 
Published: March 2024

Pharmaceutical marketing is becoming more and more personal as businesses aim to adjust their goods and services to the specific requirements of each patient. This personalization is made possible by technological advancements, which make use of big data, artificial intelligence, and machine learning.
Pharmaceutical marketing is also changing as a result of digitalization. To engage with clients, businesses are investing in online platforms, social media, and mobile apps. The transition to digital marketing is a result of customers' shifting habits, who are increasingly looking online for healthcare information and guidance. Another significant factor influencing the future of pharmaceutical marketing is regulatory developments. Fresh legislation are being passed by governments all over the world in order to protect patients and guarantee the efficacy and safety of medications. This is- leading to greater transparency and accountability in the industry, as well as increased competition and innovation. Patient empowerment is also a significant trend in pharmaceutical marketing, with patients becoming more involved in their own healthcare decisions. This is driven by a growing awareness of the importance of patient-centered care, as well as the increasing availability of health information online.
Polyherbal effervescent granules: An abeyant leap in the management of polycystic ovarian syndrome (PCOS)
Authors: Vohra Payaam , Rane Anurag , Khochare Sanika 
Published: March 2024

Polycystic ovarian syndrome (PCOS) is a neuroendocrine metabolic disorder characterized by an irregular menstrual cycle. In this current cram, we discuss the significance of herbal remedies in the treatment of PCOS, and the chemical composition, mechanism of action, and therapeutic application of selected herbal drugs against PCOS. Herbal drugs have a promising role in treatment and efficient management of PCOS. We have reviewed various key medicinal herbs and come up with a unique polyherbal formulation and its specialized significance in PCOS management. This evaluation will be of significant use to researchers working on herbal therapies to treat PCOS. Complementary or alternative medicine, such as herbal formulations containing herbal extracts of Turmeric, Aloe Vera, mint, and fenugreek, have been highly regarded as natural sources with low side effects and additional benefits of reducing hyperandrogenism, insulin resistance, and ovarian weight. These plant-based herbal formulations can be effective in this syndrome, which affects serum levels of different hormones and ovarian morphology, representing an opportunity to investigate and discover new bioactive products. Some of the most effective herbs and their formulations that play a critical role in the treatment of PCOS are summarized in this article.
A Review Process of ANDA Filling in PMDA (Japan) and Calibration of UV in Accordance to its Regulatory Guidelines
Authors: Yadav Saurabh , Panda Subhranshu , Raikwar Ankita 
Published: March 2024

The Abbreviated New Drug Application (ANDA) filing system is an important regulatory process in Japan for the approval of generic drugs. This system allows pharmaceutical companies to submit an application for the marketing and sale of a generic drug, which has already been approved by the regulatory agency in another country. The ANDA system in Japan is similar to that of the United States and Europe, but there are some unique aspects that must be taken into account. For example, in Japan, the regulatory agency requires a separate drug master file for each active pharmaceutical ingredient, which can be a time-consuming process. UV spectrophotometry is a widely used analytical technique for the characterization of pharmaceuticals, including active pharmaceutical ingredients and finished dosage forms. The Shimadzu UV-1800 spectrophotometer is a popular instrument for this purpose, which is widely used in Japan. This instrument has a range of features that make it particularly useful for pharmaceutical analysis, including a wavelength range of 190-1100 nm, a double beam optical system, and a low stray light level. The Shimadzu UV 1800 is also compatible with a range of accessories, such as a multicell holder, which allows for the simultaneous measurement of multiple samples. The combination of the ANDA filing system and UV spectrophotometry using the Shimadzu UV-1800 is an important tool for the development and approval of generic drugs in Japan. The ANDA system allows for a streamlined regulatory process for generic drug approval, while UV spectrophotometry provides a reliable and accurate method for the characterization of pharmaceuticals. Together, these tools help to ensure the safety and efficacy of generic drugs in Japan.
A Review on Lactic Acidosis in Cardiac Surgery
Authors: Nithyakala P , Dharsshini N , Bharathi S Dhivya , Hamsavarthini S , Malini N  Indhu 
Published: March 2024

The normal range of lactate is 0-2mmol/L and value above it is considered as hyperlactatemia. It may arise due to adequate and non-adequate oxygen supply mechanisms. The major reason is likely stress–induced aerobic mechanism which shows raised results of lactate. Increased lactate levels can cause acidifying effects on the blood. There are many etiological reasons for lactic acidosis like disease condition, deficiency and alcohol. Early and late onset are two categorizations for patient with hyperlactatemia after cardiac surgery. On being the major trigger factor for lactic acidosis in cardiopulmonary surgery patients due to tissue hypoperfusion. So preventive measures before cardiac surgery should be taken.
An Overview on Sodium-Glucose Cotransporter 2 (SGLT-2) Inhibitors Induced Euglycemic Diabetic Ketoacidosis: Clinical Manifestation, Mechanism, Diagnosis, Prevention and Treatment
Authors: Aakash R , Prathap S Aswin , Raj S Deepak , Dharshne P T , Priyamalar E M Neena 
Published: March 2024

Euglycemic diabetic ketoacidosis is a transient and dangerous metabolic condition characterized by ketoacidosis and considerably lower blood glucose levels which is associated with the usage of newer class of oral antidiabetic medication known as Sodium-glucose cotransporter 2 (SGLT-2) inhibitors. The primary mechanism involved in SGLT2 inhibitors induced eDKA would due to increased lipolysis and ketone body reabsorption. SGLT2i also tend to increase the pancreatic alpha cells, which simultaneously blocks the beta cells, thereby causing an disruption in glucagon/insulin ratio that accounts to enhanced lipolysis and ketogenesis, which is clinically manifested with Fatigueness, stomach pain, nausea and vomiting resulting in reduced blood pressure and dehydration, altered psychological condition, dyspnea, rapid breathing, loss of appetite, pyrexia and tachycardia. Despite lower blood glucose levels or the absence of urine ketones, euglycemic DKA is difficult to diagnose and should be examined in the differential diagnosis of an ill patient who as a previous history of diabetes mellitus. eDKA is often triggered by insulin absence or dose drop, severe acute sickness, dehydration, strenuous activity, surgeries, low-carbohydrate meals, or heavy alcohol or drug abuse. Making the definitive diagnosis using conventional diagnostic tools and clinical standards, as well as coordinating fluid resuscitation, insulin treatment, and electrolyte replacement based on information gained from prompt patient observing and knowledge of resolution criteria, are all components of management and the prevention method includes patient and physician education on risk and precipitating factors and suspending SGLT2 inhibitors therapy may reduce SGLT2 inhibitor-induced eDKA, which are more critical. This review briefly illustrates on the signs & symptoms, mechanism of induction, investigation and diagnosis, prevention and treatment of SGLT2 inhibitors-induced Euglycemic diabetic ketoacidosis (eDKA)
Role of Artificial Intelligence in Health care System
Authors: Chauhan Dolly , Singh Rupam Kumar , Kaur Mandeep , Septa Archna , Jain Ashish 
Published: March 2024

The Indian healthcare scenario presents a spectrum of contrasting landscapes. In all, 400 million individuals had no access to any form of basic healthcare while two billion people do not have access to required medications. Therefore, more than one-fourth of the world population has unmet health needs. This leaves the global community with the challenge of how to support a significant number of the world’s populace still lacking in access to basic healthcare facilities. AI has been a disruptive healthcare innovation. With its sophisticated algorithms and several applications, AI has assisted doctors and medical professionals in the domains of health information systems, geocoding health data, epidemic and syndromic surveillance, predictive modelling and decision support, and medical imaging. Artificial intelligence (AI) rapidly dominates the health service system. It removes the manual health system into automatic, in which humans conduct the routine works/tasks in medical practice to the management of patients and medical resources. Drug development is a famously costly procedure. Machine Learning can improve the efficiency of many of the analytical techniques used in drug development. In terms of practical implications, this paper aims to create a fruitful discussion with healthcare professionals and administrative staff and the role of artificial intelligence in healthcare system. Furthermore, this investigation offers a broad comprehension of bibliometric variables of AI techniques in healthcare.
To Study the Prescription Pattern of Antihypertensive Drugs in Teerthanker Mahaveer Hospital Moradabad (U.P.)
Authors: Kumar Sharad , Bedi Ashish , Kumar Arun , Tomer Sheetal Singh 
Published: March 2024

Objective of the study: To assess prescribing pattern of antihypertensive drugs use and adherence to various clinical guidelines in the Hospital. Materials and methods: A prospective observational study was carried out for a period of six months in the IPD and OPD tertiary care hospital. Prescriptions were analyzed during the study period. All the patients of age ≥ 20 (20-70 age) years with or without comorbidities, including males and females, who were diagnosed with hypertension as per JNC 8, ESH/ESC, NICE, STG, IHG, and receiving antihypertensive drugs were included. Discussion: The results of our study suggested that out of the total number of hypertensive patients (202) males were 54.45% witch females were 45.55%. Therefore, there was immensely need of proper awareness about the hypertension and its etiologies among the population especially of younger generation. In this scenario, clinical pharmacist could do a lot more for the patients and overall society because of their expertise in Pharmaceutical Care. Conclusion: Calcium channel blockers, Diuretics, ARB as monotherapy and ARB with CCB as combination therapy were the choices for the treatment of Hypertensive patients as a single drug and combination drug therapy. As per the JNC 8 & ESC/ESH guidelines majority of the prescription patterns were achieved and found optimal at the study site.
To evaluate the anti-oxidant and anti-diabetic action of Dolichos Trilobus Linn. in Wistar albino rats
Authors: Saxena Ritik , Singh Monika , Kumar Arun , Barman Moumita 
Published: March 2024

Aim: The chief motive for doing the research is to estimate the therapeutic outcomes of aqueous extract of Dolichos trilobus to respond diabetes induced by Streptozotocin. Materials & methods: The primary focus is to calculate the therapeutic effects of Dolichos trilobus given once orally to the two test groups. Thirty Wistar Albino rats were equally circulated between five groups. Study of Dolichos trilobus aqueous extract was carried out for 21 days. During this period twelve rats were divided to form two different groups and were given a dose of“200 mg/kg/day, 400 mg/kg/day”. No mortality was seen at 400mg/kg even after constantly dosing for next 21 days, considered it safe. Control group was given distilled water on the dose of 10ml/kg/day orally. Streptozotocin was given to both the Negative group as well as Standard group on the dose of 60mg/kg/day via Intra-peritoneal route. Glibenclamide has been set to the Standard group on the dose of 10mg/kg/day orally. Aqueous extract of Dolichos trilobus (Sickle Bean) was given to the Test-1 group on the dose of 200mg/kg/day orally. Aqueous extract of Dolichos trilobus was given to the Test-2 group at a dose of 400mg/kg/day orally. Results: Streptozotocin causes hypoinsulinemia and hyperglycemia due to production of pancreatic islet β-cell destruction. The diabetes was confirmed by increased level of glucose in blood, lipid per oxidation (MDA level), reduction in GSH level, food intake, body weight and histopathological variations were seen in negative group are compared to control group. This evaluation has shown that there was no major diversity in between Standard group and Test-3 (Aqueous extract of Dolichos trilobus 200 mg/kg) group. It means Test-3 have nearly same therapeutic efficacy as standard drug. Conclusion: The conclusion of the research indicates that the aqueous extract for
Review on "Herbal Preparations from Ayurveda used to treat Rheumatoid Arthritis"
Authors: Bharatia Rakesh , Gupta Nidhi , Upadhyay Preeti , Kumar Shailendra 
Published: March 2024

Ayurveda is a natural medicine system that originated in India over 3,000 years ago. The name "Ayurveda" (science or knowledge) is derived from the Sanskrit words Ayur (life) and Veda. Thus, the name Ayurveda, which means "knowledge of life." The popularity of Ayurveda, or traditional. Since most patients begin taking conventional medications as soon as they are diagnosed, ayurvedic therapies are usually administered in combination with or after orthodox medical techniques. To properly grasp the potential effect of food, spices, and medicinal plants, one must have a thorough understanding of their actions. Realizing the potential of Ayurvedic medicine and philosophy and incorporating it into contemporary medical practice is crucial. There are some significant differences between the mechanisms of action of synthetic pharmaceuticals and single constituents and those of polyherbal treatments and their extracts. Despite being based on natural herbal elements, the safety of ayurvedic treatments depends on how they are delivered, taking into account the needs of the individual and their specific sickness circumstances. Many contemporary drugs are derived from the botanicals used in Ayurveda and other traditional medicinal systems. It is expected that a significant step toward resolving some of the current challenges in treating complex disorders like arthritis with only modern pharmaceuticals would be the confirmation of a combined therapy strategy (Ayurveda and contemporary medicine) with improved efficacy and safety.
A Systematic Review: Safety and Efficacy of Anticoagulation therapy for Atrial fibrillation and venous thromboembolism
Authors: Parveen Sadia , Vashist Ankit , Jain Neha , Singh Ravindra Pal , Chanana Arsh 
Published: March 2024

For the prevention and treatment of thrombosis, anticoagulants continue to be the principal approach. Since direct thrombin inhibitors are usually saved for patients who need intervention or who have complications, unfractionated heparin, low molecular weight heparin, and warfarin have all been thoroughly studied and used.As a result of their improved pharmacodynamic profiles and ease of use, novel oral anticoagulants are predicted to supplant older ones once they emerge from clinical development. Of all the side effects of anticoagulants, bleeding is the most worrying. Anticoagulant pharmacology, dosage, and toxicity are widely used, so clinicians must be well-versed in these areas.
Traditionally, heparin was given to patients who needed parenteral anticoagulation, while warfarin was given to patients who needed oral anticoagulation. There has been a push to create newer, more potent anticoagulants because of warfarin's limited therapeutic index and the requirement for regular laboratory monitoring.
Effectiveness of individualized physical rehabilitation programs on post-mastectomy pain in breast cancer survivors
Authors: Odynets Tetiana , Briskin Yuriy , Sydorko Oleh , Tyshchenko Valeria , Putrov Sergiy 
Published: March 2024

IntroductionThe aim of the study was to determine the effectiveness of individualized physical rehabilitation programs targeted at reducing post-mastectomy pain in breast cancer survivors.MethodsOverall, 115 women with post-mastectomy pain were enrolled. The subjects had undergone surgical treatment and adjuvant radiation therapy for breast cancer. They were randomly assigned for the first (group A, <i>n</i> = 45), second (group B, <i>n</i> = 40), and third individualized physical rehabilitation program (group C, <i>n</i> = 30). The first program included aqua aerobics (aqua jogging, aqua building, aqua stretching), conditional swimming, and recreational aerobics; the second program included conditional swimming and Pilates exercises; the third program included yoga-based exercises and stretching. All participants received 140 sessions of rehabilitation intervention during the year and were evaluated at the beginning of the study, at 6, and at 12 months.ResultsIt was observed that most of the investigated pain characteristics in all studied groups steadily improved during the year of rehabilitation. After 6 months of rehabilitation, the average value of cognitive quality of pain was statistically higher in group C compared with group A by 0.43 points (<i>p</i> < 0.01).ConclusionsThe findings suggest that the first individualized physical rehabilitation program brought about the greatest pain reduction in the affected breast and upper extremity in breast cancer survivors of the studied groups.