bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFTA: An Efficient and Fault-Tolerant Data Aggregation Scheme without TTP in Smart Grid
Authors: Mei Xianyun , Wang Liangliang , Qin Baodong , Zhang Kai , Long Yu 
Published: February 2024

Abstract
With the rapid construction and implementation of smart grid, lots of studies have been conducted to explore how to ensure the security of information privacy. At present, most privacy-preserving data aggregation schemes in smart grid achieve privacy data protection through homomorphically encrypted data aggregation. However, these data aggregation schemes tend to rely on a trusted third party (TTP), and fail to efficiently handle the case of a meter failure. Besides, they are less flexible for overall user management, and resistance to collusion attacks needs to be improved. In this paper, we propose an efficient and robust privacy-preserving data aggregation scheme without TTP, called EFTA. Overall, the scheme eliminates the reliance on a TTP, combines with Shamir threshold secret sharing scheme to increase overall fault tolerance, supports flexible and dynamic user management, and effectively defends against entity initiated collusion attacks. According to security and performance analysis results, the scheme proposed in this paper meets the multiple security requirements of smart grid, and is more efficient in terms of overall overhead compared to the existing privacy-preserving data aggregation schemes.
Subcutaneous Vedolizumab Treatment in a Real-World Inflammatory Bowel Disease Cohort Switched From Intravenous Vedolizumab: Eighteen-Month Prospective Follow-up Study
Authors: Wiken Thea H , Høivik Marte L , Anisdahl Karoline , Buer Lydia , Warren David J , Bolstad Nils , Hagen Milada , Moum Bjørn A , Medhus Asle W 
Published: February 2024

Abstract

Background
Vedolizumab has since 2021 been available as a subcutaneous formulation. We aimed to assess 18-month drug persistence and possible predictive factors associated with discontinuation, safety, serum drug profile, drug dosing, and disease activity in a real-world cohort of patients with inflammatory bowel disease switched from intravenous to subcutaneous vedolizumab maintenance treatment.

Methods
Eligible patients were switched to subcutaneous vedolizumab and followed for 18 months or until discontinuation of subcutaneous treatment. Data on preferred route of administration, adverse events, drug dosing, serum-vedolizumab, disease activity, fecal calprotectin, and C-reactive protein were collected. Persistence was described using Kaplan–Meier analysis. The impact of clinical and biochemical variables on persistence was analyzed with Cox proportional hazard models.

Results
We included 108 patients, and the estimated 18-month drug persistence was 73.6% (95% CI [64.2–80.1]). Patients in clinical remission at switch were less likely to discontinue SC treatment (HR = 0.34, 95% CI [0.16–0.73], P = .006), and patients favoring intravenous treatment at switch were almost 3 times more likely to discontinue (HR = 2.78, 95% CI [1.31–5.90], P = .008). Four patients discontinued subcutaneous vedolizumab due to injection site reactions. At 18 months, 88% of patients administered subcutaneous vedolizumab with an interval of ≥ 14 days, and serum-vedolizumab was 39.1 mg/L. Disease activity was stable during follow-up.

Conclusions
Three of the four patients remained on subcutaneous vedolizumab after 18 months, a large proportion received treatment at standard dosing intervals, and disease activity remained stable. This indicates that switching from intravenous to subcutaneous vedolizumab treatment is convenient and safe.
Trapping strategy and diel periodicity affect capture rate ofHalyomorpha halys(Hemiptera: Pentatomidae) in agroecosystems
Authors: Tillman P Glynn , Grabarczyk Erin E , Kesheimer Katelyn A , Cottrell Ted 
Published: February 2024

AbstractThe polyphagous pest, Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), damages fruit in orchards and field crops and is often found within nearby woodlands. Pheromone-baited traps can be used to monitor H. halys. However, the efficiency of trapping H. halys may vary depending on trapping strategy (live vs. dead capture), location (ground or canopy), and diel periodicity of captures. We compared H. halys capture within fruiting hosts for: (i) live and kill traps on the ground vs. traps in the canopy of black cherry (Prunus serotina Ehrh.) (Rosales: Rosaceae), sugarberry (Celtis laevigata Willdenow) (Rosales: Cannabaceae), and pecan (Carya illinoinensis (Wangenh.) K. Koch) (Fagales: Juglandaceae) trees, (ii) ground and canopy-live traps in sassafras (Sassafras albidum (Nutt.) Nees) (Laurales: Lauraceae), and (iii) whether diel periodicity was detected for live capture in sassafras and cotton. More H. halys adults and nymphs were captured in kill traps than in live traps. More nymphs were captured in kill traps in black cherry and sugarberry on the ground than in the canopy. Live adult capture was significantly greater in sassafras and pecan canopies than on the ground. In cotton and sassafras, more live adults were captured from 8 PM—noon, with the fewest captured from noon—6 PM. A better understanding of stink bug activity in the field allows for improved trapping and, possibly, improved timing of treatment applications.
Efficacy and safety of oral anticoagulants according to kidney function among patients with atrial fibrillation
Authors: Binding Casper , Blanche Paul , Lip Gregory Y H , Kamper Anne-Lise , Lee Christina J Y , Staerk Laila , Gislason Gunnar , Torp-Pedersen Christian , Olesen Jonas Bjerring , Bonde Anders Nissen 
Published: February 2024

Abstract

Background and aims
Patients with severely reduced kidney function have been excluded from randomized controlled trials and data on the safety and efficacy of direct oral anticoagulants (DOACs) according to kidney function remain sparse. The aim was to evaluate the safety and efficacy of the DOACs across subgroups of kidney function.

Methods
Using multiple Danish nationwide registers and laboratory databases, we included patients initiated on oral anticoagulants (OACs) with atrial fibrillation and available creatinine level and followed patients for 2 years to evaluate occurrence of stroke/thromboembolism (TE) and major bleeding.

Results
Among 26 686 included patients, 3667 (13.7%) had an estimated glomerular filtration rate (eGFR) of 30–49 mL/min/1.73 m2 and 596 (2.2%) had an eGFR below 30 mL/min/1.73 m2. We found no evidence of differences regarding the risk of stroke/TE between the OACs (P-value interaction &gt;0.05 for all). Apixaban was associated with a lower 2-year risk of major bleeding compared to vitamin K antagonists (VKA) [hazard ratio 0.79, 95% confidence interval (CI) 0.67–0.93], and the risk difference was significantly larger among patients with reduced kidney function (P-value interaction 0.018). Rivaroxaban was associated with a higher risk of bleeding compared to apixaban (hazard ratio 1.78, 95%CI 1.32–2.39) among patients with eGFR 30–49 mL/min/1.73 m2.

Conclusions
Overall, we found no differences regarding the risk of stroke/TE, but apixaban was associated with a 21% lower relative risk of major bleeding compared to VKA. This risk reduction was even greater when comparing apixaban to VKA among patients with eGFR 15–30 mL/min/1.73 m2, and when comparing apixaban to dabigatran and rivaroxaban among patients with eGFR 30–49 mL/min/1.73 m2.
‘I drew it in as simply as my breath’: absence, presence, and ideal beauty in Dante Gabriel Rossetti’s Sibylla Palmifera (1866–70) ‘double work of art’
Authors: Dunn-McAfee Nicholas 
Published: February 2024

Abstract
Dante Gabriel Rossetti’s Sibylla Palmifera or Soul's Beauty (1866–1870) ‘double work of art’ is one of his most recognizable pictures and anthologized poems. His visual-verbal ‘double works’ – typically painting-sonnet composites that share a title, comment on each other, and elaborate on a joint subject – remain, however, understudied. Their cross-medium composition presents a challenge to segregated art-historical and literary scholarship. Almost all studies on these picture-word composites take a monodisciplinary approach and predominantly address a single component: the picture or the poem. Engagement with the other component is either cursory or non-existent. In (re)constructing the Sibylla ‘double works’, this essay argues for a renewed understanding of the viewer-reader and viewing-reading. The formation of the visual-verbal exchange at the heart of the ‘double work’ also results in problematic gaps, dissonances, and ruptures in visual-verbal representation. In a manner yet to be addressed in scholarship, this essay demonstrates how Rossetti exploits both alignment and divergence in the Sibylla ‘double work’ to inform and structure the viewer-reader’s encounter with the absence and presence generated by ideal beauty. By reassessing the wider relationship between (and experience of) picture and word, this essay situates the ‘double work’ form at the centre of image-text studies – and exposes the challenge that they present to disparate scholarship and methodologies.
Novel strains of Actinobacteria associated with neotropical social wasps (Vespidae; Polistinae, Epiponini) with antimicrobial potential for natural product discovery
Authors: Chavarría-Pizarro Laura , Núñez-Montero Kattia , Gutiérrez-Araya Mariela , Watson-Guido William , Rivera-Méndez William , Pizarro-Cerdá Javier 
Published: February 2024

Abstract
Antimicrobial resistance has been considered a public health threat. The World Health Organization has warned about the urgency of detecting new antibiotics from novel sources. Social insects could be crucial in the search for new antibiotic metabolites, as some of them survive in places that favor parasite development. Recent studies have shown the potential of social insects to produce antimicrobial metabolites (e.g. ants, bees, and termites). However, most groups of social wasps remain unstudied. Here, we explored whether Actinobacteria are associated with workers in the Neotropical Social Wasps (Epiponini) of Costa Rica and evaluated their putative inhibitory activity against other bacteria. Most isolated strains (67%) have antagonistic effects, mainly against Bacillus thuringensis and Escherichia coli ATCC 25992. Based on genome analysis, some inhibitory Actinobacteria showed biosynthetic gene clusters (BGCs) related to the production of antimicrobial molecules such as Selvamycin, Piericidin A1, and Nystatin. The Actinobacteria could be associated with social wasps to produce antimicrobial compounds. For these reasons, we speculate that Actinobacteria associated with social wasps could be a novel source of antimicrobial compounds, mainly against Gram-negative bacteria.
DHCR24 Insufficiency Promotes Vascular Endothelial Cell Senescence and Endothelial Dysfunction via Inhibition of Caveolin-1/ERK Signaling
Authors: Li Han , Yang Zhen , Liang Wukaiyang , Nie Hao , Guan Yuqi , Yang Ni , Ji Tianyi , Liu Yu , Huang Yi , Zhang Le , Yan Jinhua , Zhang Cuntai 
Published: February 2024

Abstract
Endothelial cells (ECs) senescence is critical for vascular dysfunction, which leads to age-related disease. DHCR24, a 3β-hydroxysterol δ 24 reductase with multiple functions other than enzymatic activity, has been involved in age-related disease. However, little is known about the relationship between DHCR24 and vascular ECs senescence. We revealed that DHCR24 expression is chronologically decreased in senescent human umbilical vein endothelial cells (HUVECs) and the aortas of aged mice. ECs senescence in endothelium-specific DHCR24 knockout mice was characterized by increased P16 and senescence-associated secretory phenotype, decreased SIRT1 and cell proliferation, impaired endothelium-dependent relaxation, and elevated blood pressure. In vitro, DHCR24 knockdown in young HUVECs resulted in a similar senescence phenotype. DHCR24 deficiency impaired endothelial migration and tube formation and reduced nitric oxide (NO) levels. DHCR24 suppression also inhibited the caveolin-1/ERK signaling, probably responsible for increased reactive oxygen species production and decreased eNOS/NO. Conversely, DHCR24 overexpression enhanced this signaling pathway, blunted the senescence phenotype, and improved cellular function in senescent cells, effectively blocked by the ERK inhibitor U0126. Moreover, desmosterol accumulation induced by DHCR24 deficiency promoted HUVECs senescence and inhibited caveolin-1/ERK signaling. Our findings demonstrate that DHCR24 is essential in ECs senescence.
Systematic adjustment of root dimensions to cusp size in aortic valve repair: a computer simulation
Authors: Marom Gil , Weltert Luca Paolo , Raanani Ehud , Chirirchilli Ilaria , Giebels Christian , Irace Francesco Giosuè , De Paulis Ruggero , Schäfers Hans-Joachim 
Published: February 2024

Abstract

OBJECTIVES
Aortic valve repair requires the creation of a normal geometry of cusps and aortic root. Of the different dimensions, geometric cusp height is the most difficult to change while annular and sinotubular dimensions can be easily modified. The objective of this study was to investigate, by computer simulation, ideal combinations of annular and sinotubular junction size for a given geometric height.

METHODS
Based on a literature review of anatomical data, a computational biomechanics model was generated for a tricuspid aortic valve. We aimed to determine the ideal relationships for the root dimensions, keeping geometric height constant and creating different combinations of the annular and sinotubular junction dimensions. Using this model, 125 virtual anatomies were created, with 25 different combinations of annulus and sinotubular junction. Effective height, coaptation height and mechanical cusp stress were calculated with the valves in closed configuration.

RESULTS
Generally, within the analysed range of geometric heights, changes to the annular diameter yielded a stronger impact than sinotubular junction diameter changes for optimal valve configuration. The best results were obtained with the sinotubular junction being 2–4 mm larger than the annulus, leading to higher effective height, normal coaptation height and lower stress. Within the range tested, stenosis did not occur due to annular reduction.

CONCLUSIONS
In tricuspid aortic valves, the geometric height can be used to predict ideal post-repair annular and sinotubular junction dimensions for optimal valve configuration. Such an ideal configuration is associated with reduced cusp stress.
Assessment of the Zoonotic Potential of Atypical Scrapie Prions in Humanized Mice Reveals Rare Phenotypic Convergence but Not Identity With Sporadic Creutzfeldt-Jakob Disease Prions
Authors: Marín-Moreno Alba , Reine Fabienne , Herzog Laetitia , Aron Naima , Jaffrézic Florence , Vilotte Jean-Luc , Rezaei Human , Andréoletti Olivier , Martin Davy , Béringue Vincent 
Published: February 2024

Abstract

Background
Atypical/Nor98 scrapie (AS) is an idiopathic infectious prion disease affecting sheep and goats. Recent findings suggest that zoonotic prions from classical bovine spongiform encephalopathy (C-BSE) may copropagate with atypical/Nor98 prions in AS sheep brains. Investigating the risk AS poses to humans is crucial.

Methods
To assess the risk of sheep/goat-to-human transmission of AS, we serially inoculated brain tissue from field and laboratory isolates into transgenic mice overexpressing human prion protein (Met129 allele). We studied clinical outcomes as well as presence of prions in brains and spleens.

Results
No transmission occurred on the primary passage, with no clinical disease or pathological prion protein in brains and spleens. On subsequent passages, 1 isolate gradually adapted, manifesting as prions with a phenotype resembling those causing MM1-type sporadic Creutzfeldt-Jakob disease in humans. However, further characterization using in vivo and in vitro techniques confirmed both prion agents as different strains, revealing a case of phenotypic convergence. Importantly, no C-BSE prions emerged in these mice, especially in the spleen, which is more permissive than the brain for C-BSE cross-species transmission.

Conclusions
The results obtained suggest a low zoonotic potential for AS. Rare adaptation may allow the emergence of prions phenotypically resembling those spontaneously forming in humans.
A Vicsek-type model of confined cancer cells with variable clustering affinities
Authors: Kirchner Zachary , Geohagan Anna , Truszkowska Agnieszka 
Published: February 2024

Abstract
Clustering of cells is an essential component of many biological processes from tissue formation to cancer metastasis. We develop a minimal, Vicsek-based model of cellular interactions that robustly and accurately captures the variable propensity of different cells to form groups when confined. We calibrate and validate the model with experimental data on clustering affinities of four lines of tumor cells. We then show that cell clustering or separation tendencies are retained in environments with higher cell number densities and in cell mixtures. Finally, we calibrate our model with experimental measurements on the separation of cells treated with anti-clustering agents and find that treated cells maintain their distances in denser suspensions. We show that the model reconstructs several cell interaction mechanisms, which makes it suitable for exploring the dynamics of cell cluster formation as well as cell separation.
Insight: We developed a model of cellular interactions that captures the clustering and separation of cells in an enclosure. Our model is particularly relevant for microfluidic systems with confined cells and we centered our work around one such emerging assay for the detection and research on clustering breast cancer cells. We calibrated our model using the existing experimental data and used it to explore the functionality of the assay under a broader set of conditions than originally considered. Future usages of our model can include purely theoretical and computational considerations, exploring experimental devices, and supporting research on small to medium-sized cell clusters.
Biology, distribution, and conservation of the Gamilaroi crayfish Euastacus gamilaroi Morgan, 1997 (Decapoda: Astacidea: Parastacidae), a freshwater crayfish from New South Wales, Australia
Authors: McCormack Robert B , Whiterod Nick S 
Published: February 2024

Abstract
Euastacus gamilaroi Morgan 1997, the Gamilaroi crayfish, was initially described based on specimens collected in 1954 from Hanging Rock, New South Wales, but since then scant subsequent records hinder conservation of this endangered species. Extensive sampling during 2006–2023 delineated the distribution, habitat preferences, biological traits, and conservation status of the species. Together with concurrent molecular taxonomic analyses were extend the species range from headwater regions of highland streams above 960 m altitude of Burrows Creek to include highland streams of Duncan and Dungowan creeks (Peel-Namoi River/western drainage) and Tomalla, Back, and Ben Halls creeks (Barnard-Manning River/eastern drainage). We provide information on the distribution, biology, and ecological associations of the species. Results advocate for the classification of E. gamilaroi as an endangered species, recognizing its distinctive ecological niche and its status as a climate refugee, aiming to protect this rare species from climate-related challenges. We also present a taxonomic key differentiating E. gamilaroi from other species of Parastacidae in the region.
A method for sampling parasitized Drosophila suzukii (Diptera: Drosophilidae) puparia from soil
Authors: Capko Clarissa , Thiessen Jason , Harach Lana , Fraser Jessica L , Franklin Michelle T , Abram Paul K 
Published: February 2024

Abstract
Methods to measure the diversity and biological control impact of parasitoids for the control of spotted-wing drosophila, Drosophila suzukii (Matsumura) (Diptera: Drosophilidae) are being developed in support of biological control programs around the world. Existing methods to determine parasitism levels and parasitoid species composition focus on sampling D. suzukii within fresh and rotting fruit. However, many D. suzukii pupate in the soil or in dropped fruit, where additional parasitism could occur and where their parasitoids are thought to overwinter. Here we introduce a method for extracting parasitized D. suzukii puparia from the soil through a sieve and flotation system, allowing for effective collection of puparia, from which parasitoids can then be reared. Although the method considerably underestimates the absolute number of puparia in soil samples, it nonetheless yields a high number of puparia relative to sampling effort and provides a robust estimate of the relative abundance of puparia among samples. Using this method, we confirmed that at least 5 species of parasitoids, including some that have rarely been detected in past studies, overwinter in their immature stages inside D. suzukii puparia in south coastal British Columbia, Canada. The ability to sample puparia from the soil will lead to a more comprehensive view of both D. suzukii and parasitoid abundance throughout the season, help confirm parasitoid establishment following intentional releases, and provide a way to measure the diversity of parasitoid species and potential interactions among parasitoids (e.g., hyper- or klepto-parasitism) that may often occur on the soil surface.
Parasitoid–host interaction behaviors in relation to host stages in the Tamarixia triozae (Hymenoptera: Eulophidae)–Bactericera cockerelli (Hemiptera: Triozidae) system
Authors: Chen Chen , He Xiong Z , Zhou Peng , Wang Qiao 
Published: February 2024

Abstract
Females of host-feeding parasitic wasps often partition hosts of different stages for feeding and parasitization, but the underlying behavioral mechanisms are largely unknown, making it difficult to evaluate parasitoid–host interactions and their effects on biological control success. Tamarixia triozae (Burks) is an ectoparasitoid of tomato-potato psyllid Bactericera cockerelli (Šulc), which utilizes nymphs and kills them both by parasitization and host feeding. In this study, we exposed female wasps to 1st- to 5th-instar psyllid nymphs simultaneously and made 13-h continuous video recording of parasitoid–host interactions. We then quantified host stage-dependent handling time for feeding and oviposition and behaviors of parasitoid attacks and host defenses from encountering to successful feeding and oviposition. Female wasps were more likely to encounter and evaluate older hosts. However, the encounter and evaluation did not necessarily result in the success of feeding and oviposition. Our findings suggest that (i) T. triozae continues to assess the host using its ovipositor after the evaluation phase, (ii) females prefer the mid-aged hosts for feeding piercing and feeding and the later instars for oviposition probing and oviposition, (iii) the combination of stage-specific host nutrition value, integument thickness and defense behavior determines the success of feeding attacks, and (iv) the optimal host resource for parasitoid offspring fitness defines host stage selection for oviposition. This study contributes to our understanding of parasitoid–host interactions and mechanisms behind host stage selections.