bluuebunny/crossref_metadata_2025_split huggingface dataset:
An IoT-based low-cost architecture for smart libraries using SDN
Authors: Xu Hui , Liu Wei-dong , Li Lu , Zhou Qi 
Published: March 2024

AbstractIn the evolving landscape of smart libraries, this research pioneers an IoT-based low-cost architecture utilizing Software-Defined Networking (SDN). The increasing demand for more efficient and economical solutions in library management, particularly in the realm of RFID-based processes such as authentication, property circulation, and book loans, underscores the significance of this study. Leveraging the collaborative potential of IoT and SDN technologies, our proposed system introduces a fresh perspective to tackle these challenges and advance intelligent library management. In response to the evolving landscape of smart libraries, our research presents an Internet of Things (IoT)-based low-cost architecture utilizing SDN. The exploration of this architectural paradigm arises from a recognized gap in the existing literature, pointing towards the necessity for more efficient and cost-effective solutions in managing library processes. Our proposed algorithm integrates IoT and SDN technologies to intelligently oversee various library activities, specifically targeting RFID-based processes such as authentication, property circulation management, and book loan management. The system's architecture, encompasses components like the data center, SDN controllers, RFID tags, tag readers, and other network sensors. By leveraging the synergy between RFID and SDN, our innovative approach reduces the need for constant operator supervision in libraries. The scalability and software-oriented nature of the architecture cater to extensive library environments. Our study includes a two-phase investigation, combining practical implementation in a small-scale library with a simulation environment using MATLAB 2021. This research not only fills a crucial gap in current knowledge but also lays the foundation for future advancements in the integration of IoT and SDN technologies for intelligent library management.
Unexpected identification of obesity-associated mutations in LEP and MC4R genes in patients with anorexia nervosa
Authors: Rajcsanyi Luisa Sophie , Zheng Yiran , Herpertz-Dahlmann Beate , Seitz Jochen , de Zwaan Martina , Herzog Wolfgang , Ehrlich Stefan , Zipfel Stephan , Giel Katrin , Egberts Karin , Burghardt Roland , Föcker Manuel , Antel Jochen , Fischer-Posovszky Pamela , Hebebrand Johannes , Hinney Anke 
Published: March 2024

AbstractMutations leading to a reduced or loss of function in genes of the leptin-melanocortin system confer a risk for monogenic forms of obesity. Yet, gain of function variants in the melanocortin-4-receptor (MC4R) gene predispose to a lower BMI. In individuals with reduced body weight, we thus expected mutations leading to an enhanced function in the respective genes, like leptin (LEP) and MC4R. Therefore, we have Sanger sequenced the coding regions of LEP and MC4R in 462 female patients with anorexia nervosa (AN), and 445 healthy-lean controls. In total, we have observed four and eight variants in LEP and MC4R, respectively. Previous studies showed different functional in vitro effects for the detected frameshift and non-synonymous variants: (1) LEP: reduced/loss of function (p.Val94Met), (2) MC4R: gain of function (p.Val103Ile, p.Ile251Leu), reduced or loss of function (p.Thr112Met, p.Ser127Leu, p.Leu211fsX) and without functional in vitro data (p.Val50Leut). In LEP, the variant p.Val94Met was detected in one patient with AN. For MC4R variants, one patient with AN carried the frameshift variant p.Leu211fsX. One patient with AN was heterozygous for two variants at the MC4R (p.Val103Ile and p.Ser127Leu). All other functionally relevant variants were detected in similar frequencies in patients with AN and lean individuals.
Pharmacokinetic and pharmacodynamic evaluation study of etomidate: a randomized, open-label, 2-period crossover study in healthy Chinese subjects
Authors: Ding Ying , Chu Nan-nan , Wang Rui , Qin Wei , Shi Yun-fei , Qian Zhen-zhong , Liu Bo , He Qing 
Published: March 2024

AbstractEtomidate is a sedative and hypnotic drug through intravenous administration that act on the central nervous system through GABA (Gamma-Amino Butyric Acid) receptors, which is widely used in anesthesia induction and maintenance and long-term sedation in severe patients. The study aimed to evaluate the pharmacokinetic and pharmacodynamic properties of two etomidate fat emulsions after administration through the intravenous infusion pump in healthy Chinese subjects. A randomized, open-label, 2-period crossover study was performed in 52 healthy subjects. The wash-out period was 7 days. Blood samples and pharmacodynamic index values were collected at the specified time points. Etomidate concentrations were measured using validated liquid chromatography-tandem mass spectrometry. Pharmacokinetic parameters were analyzed using a non-compartment model method. Pharmacodynamic parameters were calculated using pharmacodynamic index values. The study also evaluated the safety of the etomidate. Both the pharmacokinetic parameters and pharmacodynamic parameters result of the test and reference formulation were very similar. The 90% confidence intervals (CI) of the geometric least-squares mean (GLSM) ratios of the test to reference formulation were 91.33–104.96% for the maximum plasma concentration (Cmax), 97.21–102.03% for the area under the plasma concentration time curve from time 0 to the time of the last measurable concentration (AUC0–t), and 97.22–102.33% for the area under the plasma concentration time curve from time 0 to infinity (AUC0–∞). Meanwhile, the 90% CI of the GLSM ratios of the test to reference formulation were 102.28–110.69% for the minimal BIS value (BISmin), 99.23–101.17% for the area under the BIS time curve from time 0–60 min after administration (BISAUC0–60 min), respectively. The 90% CI of these pharmacokinetic and pharmacodynamic parameters all fall in the accepted bioequivalence range of 80.00–125.00%. No serious adverse events occurred during the study. This study has shown that the etomidate fat emulsion test and reference formulation had similar pharmacokinetic and pharmacodynamic characteristics in vivo. The two formulations exhibited good safety and well-tolerance.Clinical trials registration number:http://www.chinadrugtrials.org.cn/index.html. # CTR20191836.
Detecting abnormal cell behaviors from dry mass time series
Authors: Bailly Romain , Malfante Marielle , Allier Cédric , Paviolo Chiara , Ghenim Lamya , Padmanabhan Kiran , Bardin Sabine , Mars Jérôme 
Published: March 2024

AbstractThe prediction of pathological changes on single cell behaviour is a challenging task for deep learning models. Indeed, in self-supervised learning methods, no prior labels are used for the training and all of the information for event predictions are extracted from the data themselves. We present here a novel self-supervised learning model for the detection of anomalies in a given cell population, StArDusTS. Cells are monitored over time, and analysed to extract time-series of dry mass values. We assessed its performances on different cell lines, showing a precision of 96% in the automatic detection of anomalies. Additionally, anomaly detection was also associated with cell measurement errors inherent to the acquisition or analysis pipelines, leading to an improvement of the upstream methods for feature extraction. Our results pave the way to novel architectures for the continuous monitoring of cell cultures in applied research or bioproduction applications, and for the prediction of pathological cellular changes.
Skiing economy and kinematic during a field double poling roller skiing among novice and experienced cross-country skiers
Authors: Zhu Yang , Wang Zhiqiang , Li Ruoyang , Li Yanyan , Bai Peng , Gao Weifeng , Zhong Yaping 
Published: March 2024

AbstractTo assess the skiing economy (SE) and kinematics during double poling (DP) roller skiing between two groups of skiers in a field setting. Five experienced and five novice male skiers performed a SEDP test at 16 km∙h−1 on an outdoor athletics track. Gas exchange parameters were measured to determine SEDP. A two-dimensional video was filmed to measure the kinematics variables. Experienced skiers exhibited a 21% lower oxygen cost than novice skiers (p = 0.016) in DP, indicating a strong association between SEDP, cycle length and cycle rate (p < 0.001). Additionally, before the poling phase, experienced skiers manifested significantly greater maximum hip and knee extension angles than novice skiers (p < 0.001). During the poling phase, experienced skiers with a greater pole plant angle (p = 0.001), longer flexion time (p < 0.001) and higher flexion angular velocity in the elbow joint (p < 0.05) demonstrated better SEDP. There was an interaction effect of the one-repetition maximum bench press × group in SEDP (b = − 0.656, SE = 0.097, t = − 6.78, p = 0.001). Therefore, experienced skiers with better SEDP demonstrated more efficient cycles, potentially accomplished using dynamic full-body DP motion to ascertain effective propulsion. Combined upper body strength and ski-specific skill training may enhance SEDP in novice skiers.
A Facile Procedure for Halodecarboxylation of Hydroxyaromatic Carboxylic Acids
Authors: Zhang Zhenbei , Bakumenko Olha , Xue Feng , Sun Wenhui , Cao Zhishan , Zhang Guisheng 
Published: March 2024

AbstractAn efficient approach is reported for the direct halodecarboxylation of hydroxyaromatic acids by using a readily available N-halosuccinimide (halo = Cl, Br) as the sole promoter in ethanol at room temperature without any other catalyst or additive. This environmentally friendly route tolerates a wide substrate scope with good to excellent yields under convenient conditions.
Commemoration and radical right-wing populism in European borderlands
Authors: Lamour Christian 
Published: March 2024

Abstract
The success of radical right-wing populist (RRWP) parties is based on discourses displaying “power geometries”
(Massey 1993, 1999). These involve the
representation of power relations, with on one side a globalized elite, boosting the mobility of human beings, goods and capital
across borders, and on the other side, a territorially embedded people subject to this borderless mobility. Power geometries can
also be used to approach the chameleonic behavior of RRWP politicians and their allies in the political space. The article uses
this concept to interpret the attitude of the Trieste City Executive and the reactions to it when it commemorated a past connected
to Italian fascism. The results show that the power geometries involving the RRWP and their allies in European borderlands can
lead to discursive ambivalence in two overlapping spaces: the territorial and state-bordered space of representative democracy,
and the topological and cross-border space of para-diplomacy.
Terahertz refractive index sensor based on dual plasmon-induced transparency in a graphene metasurface
Authors: Yang Xiaojie , Xu Hui , Xu Haiye , Li Ming , Yu Hongfei , Cheng Yuxuan , Chen Zhiquan 
Published: March 2024

Abstract
A novel graphene metasurface is proposed in this article, which is simulated by the finite difference time domain (FDTD) and found to exhibit a significant dual Plasmon-induced transparency (PIT) phenomenon in the terahertz frequency band. For further research, new transmission spectra are simulated using the coupled mode theory (CMT), and after comparison, it is found that the images were basically consistent and had a high degree of agreement. In addition, through observation and analysis of the PIT window, it is found that the PIT phenomenon can be effectively tuned by adjusting the Fermi level. Finally, the metasurface is proposed in this article, which has excellent sensing properties. After calculation and comparison of different refractive indices of surrounding media, it is found that the maximum sensitivity can reach 1.567 THz RIU−1 at a frequency of f = 4.8716 THz, with a figure of merit (FOM) of 23.855. Compared with other sensors of the same type, the sensor in this paper has great advantages. In summary, the graphene metasurface proposed in this article provides more theoretical support for manufacturing dynamically adjustable graphene sensors.
Formalizing screw theory with 3D geometric algebra
Authors: Delafosse Loris 
Published: March 2024

Abstract
This paper is intended for students and researchers looking for more insight into Screw Theory. It shows how algebraic considerations lead to both physical and geometrical understanding of screws, and how they can connect affine geometry (what the world is) to linear algebra (what we can easily compute). Various formulations of the theory are first reviewed, as each of them highlights a particular aspect of screws. Their respective qualities and defects are also discussed. Subsequently, the powerful framework of Geometric Algebra (GA) is introduced to elucidate the nature of various physical objects commonly associated with screws, and eventually a new formalism based on GA is proposed, in which traditional screws clearly appear as a special case of more general affine objects. This approach generalizes the concept of a screw in a coordinate-free and origin-independent form. A simultaneous proof of Euler’s First and Second Laws is provided to illustrate the use of this formalism.
Machine-Learned Potential Energy Surfaces for Free Sodium Clusters with Density Functional Accuracy: Applications to Melting
Authors: Nagare Balasaheb J , Chacko Sajeev , Kanhere Dilip G 
Published: March 2024

Abstract
Gaussian Process Regression based Gaussian Approximation Potential has been used to develop machine learned interatomic potentials having density functional accuracy, for free sodium clusters. The training data was generated from a large sample of over 100,000 data points computed for clusters in the size range of N = 40–200, where N denotes the number of atoms in the cluster, using the density functional method as implemented in the VASP code. Two models have been developed, model M1 using data for N = 55 only, and model M2 using additional data from larger clusters. The models are intended for computing thermodynamic properties using molecular dynamics. Hence, particular attention has been paid to improve the fitting of the forces. Although it was possible to obtain a good fit using the data of Na55 only, additional data points from larger clusters were needed to get better accuracies in energies and forces for larger sizes. Surprisingly, the model M1 could be significantly improved by adding about 50 data points per cluster from the larger sizes. Thus, it turns out that the best fit can be obtained by carefully selecting a small number of data points viz. 1,900 and 1,300 configurations for the two models M1 and M2, respectively. These two models have been deployed to compute the heat capacities of Na55. The heat capacities of Na147 and about 40 isomers for larger clusters of sizes N = 147, 200, 201, and 252, have been obtained using the final model M2. There is an excellent agreement between the computed and experimentally measured melting temperatures. The geometries of these isomers have been further optimized by density functional theory. The mean absolute error with respect to DFT energies is found to be about 7 meV/atom or less. The errors in the lowest interatomic bond lengths are below 2% in almost all the cases.
Robot-assisted support combined with electrical stimulation for the lower extremity in stroke patients: a systematic review
Authors: Rikhof C J H , Feenstra Y , Fleuren J F M , Buurke J H , Prinsen E C , Rietman J S , Prange-Lasonder G B 
Published: March 2024

Abstract

Objective. The incidence of stroke rising, leading to an increased demand for rehabilitation services. Literature has consistently shown that early and intensive rehabilitation is beneficial for stroke patients. Robot-assisted devices have been extensively studied in this context, as they have the potential to increase the frequency of therapy sessions and thereby the intensity. Robot-assisted systems can be combined with electrical stimulation (ES) to further enhance muscle activation and patient compliance. The objective of this study was to review the effectiveness of ES combined with all types of robot-assisted technology for lower extremity rehabilitation in stroke patients. Approach. A thorough search of peer-reviewed articles was conducted. The quality of the included studies was assessed using a modified version of the Downs and Black checklist. Relevant information regarding the interventions, devices, study populations, and more was extracted from the selected articles. Main results. A total of 26 articles were included in the review, with 23 of them scoring at least fair on the methodological quality. The analyzed devices could be categorized into two main groups: cycling combined with ES and robots combined with ES. Overall, all the studies demonstrated improvements in body function and structure, as well as activity level, as per the International Classification of Functioning, Disability, and Health model. Half of the studies in this review showed superiority of training with the combination of robot and ES over robot training alone or over conventional treatment. Significance. The combination of robot-assisted technology with ES is gaining increasing interest in stroke rehabilitation. However, the studies identified in this review present challenges in terms of comparability due to variations in outcome measures and intervention protocols. Future research should focus on actively involving and engaging patients in executing movements and strive for standardization in outcome values and intervention protocols.
Genomic islands of speciation harbor genes underlying coloration differences in a pair of Neotropical seedeaters
Authors: Nguyen Tram N , Repenning Márcio , Suertegaray Fontana Carla , Campagna Leonardo 
Published: March 2024

Abstract
Incomplete speciation can be leveraged to associate phenotypes with genotypes, thus providing insights into the traits relevant to the reproductive isolation of diverging taxa. We investigate the genetic underpinnings of the phenotypic differences between Sporophila plumbea and Sporophila beltoni. Sporophila beltoni has only recently been described based, most notably, based on differences in bill coloration (yellow vs. black in S. plumbea). Both species are indistinguishable through mtDNA or reduced-representation genomic data, and even whole-genome sequencing revealed low genetic differentiation. Demographic reconstructions attribute this genetic homogeneity to gene flow, despite divergence in the order of millions of generations. We found a narrow hybrid zone in southern Brazil where genetically, yet not phenotypically, admixed individuals appear to be prevalent. Despite the overall low genetic differentiation, we identified 3 narrow peaks along the genome with highly differentiated SNPs. These regions harbor 6 genes, one of which is involved in pigmentation (EDN3) and is a candidate for controlling bill color. Within the outlier peaks, we found signatures of resistance to gene flow, as expected for islands of speciation. Our study shows how genes related to coloration traits are likely involved in generating prezygotic isolation and establishing species boundaries early in speciation.
Influence of reforestation tree species on decomposition of larch stumps and coarse roots: role of wood microbial communities and soil properties
Authors: Yue Yang , Men Xiuli , Chen Xiangwei 
Published: March 2024

Abstract
Stumps and coarse roots are the most important coarse woody debris component in managed forests. However, their decomposition is still poorly understood, especially the influence of the characteristics of the microbial communities on wood decomposition. In this study, we investigated decaying larch (Larix olgensis Henry) stumps and coarse roots in reforestations of birch (Betula pendula Roth.), ash (Fraxinus mandshurica Rupr.), pine (Pinus sylvestris var. Mongolica), and larch in the northeast of China. We measured wood density loss, cellulose, and lignin concentrations, analyzed microbial community composition, and assessed the physical and chemical properties of woodland soils. Our findings reveal that larch stumps and coarse roots experienced the most rapid decomposition within birch reforestation areas, exhibiting significant density loss in stumps (33.84%) and coarse roots (43.68%). Bacterial diversity on larch stumps and coarse roots was highest in birch reforestation, with dominant phyla including Proteobacteria, Actinobacteriota, and Bacteroidota. Fungal diversity was also highest in birch reforestation, with Ascomycota as the dominant phylum in larch stumps and coarse roots. Furthermore, a mantel test analysis indicated that soil pH and temperature were significant factors in wood decomposition which affected microbial communities. This suggests that the choice of the reforestation tree species affects the decomposition of stumps and coarse roots by affecting soil properties and wood microbial communities. Understanding this process is vital for refining carbon balance evaluations, and enhancing ecosystem-level carbon modeling.
Impacts of ground ultra-low volume adulticide applications on Culex pipiens and Culex restuans (Diptera: Culicidae) abundance, age structure, and West Nile virus infection in Cook County, Illinois
Authors: Lopez Kristina , Susong Katie , Irwin Patrick , Paskewitz Susan , Bartholomay Lyric 
Published: March 2024

Abstract
Since the introduction of West Nile virus (WNV) to the United States over 20 years ago, thousands of cases of human disease and death have been reported. Yearly seasonal outbreaks continue to persist, and the city and suburbs of Chicago, Illinois, is considered a “hot spot” for WNV activity. To interrupt WNV transmission, ground ultra-low volume (ULV) adulticide applications are regularly used to reduce Culex pipiens L. and Culex restuans Theobold (Diptera: Culicidae) abundance and infection. The real-world effectiveness of adulticide applications has not been comprehensively assessed, and prior studies, including our own investigation, have yielded inconclusive or conflicting results. Therefore, we expanded our prior work and evaluated the effects of 5 sequential weekly truck-mounted ULV adulticide applications in large residential areas in the northern suburbs of Chicago, Illinois, in 2019 and 2020. Each day, Cx. pipiens and Cx. restuans host-seeking and gravid mosquitoes were collected to assess abundance, age structure, and WNV infection rates. Adulticide applications resulted in significant reductions of both host-seeking and gravid abundance on the night of treatment. The reduction in host-seeking mosquitoes was followed by a reduction in gravid mosquitoes trapped 3 and 4 days after adulticide application and an increase in the proportion of nulliparous mosquitoes. WNV infection rates were significantly reduced in treatment sites as compared to untreated sites when infection rates were higher in 2020. This large-scale study provides comprehensive evidence that ground ULV adulticide applications are an effective tool in an integrated mosquito management program for combating WNV vectors and infection risk.