bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assisted reproductive technology (ART) is not an independent risk factor for breech presentation among singleton term births in Vienna, Austria
Authors: Bartsch L. , Hämmerle M. , Putschögl S. , Hartmann B. , Kirchengast S. 
Published: March 2024

AbstractAssisted reproductive technologies (ARTs) such as in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI) are still discussed critically, as there is no consensus on whether these treatments could be the cause of risk factors for obstetric problems such as breech presentation. The aim of this study was to test the association between ART and breech presentation among 11920 singleton term births taking place in Vienna from 2010 to 2020. In this single-centre medical record-based study, data concerning the conception mode (spontaneous versus IVF or ICSI), child presentation, birth mode, newborn sex and size as well as age, height, weight, and reproductive history of the mother were included. Three hundred twenty-six newborns (2.7%) were conceived by IVF or ICSI, and 527 newborns (4.4%) were delivered in breech presentation. Breech presentation occurred in 7.6% of IVF/ICSI children but only in 4.3% of spontaneously conceived children (P = 0.019). ART increased the crude risk of breech presentation significantly (OR = 1.67; 95% CI 1.71 – 2.38). After adjusting for maternal age, height, number of previous births, smoking, and newborn sex, however, ART had no longer a significant impact on the risk of breech presentation. In contrast, breech presentation was significantly associated with higher maternal age as well as a lower number of previous births, but not with ART. This study shows that the adverse outcomes of IVF and ICSI pregnancies may not be due to the ART treatment alone but might also be due to the mostly higher age and lower parity of the mothers using ART.
A trocar puncture robot for assisting venipuncture blood collection
Authors: Yang Zhikang , Wen Shikun , Qi Qian , Lv Zhuhai , Ji Aihong 
Published: March 2024

AbstractThe venous blood test is a prevalent auxiliary medical diagnostic method. Venous blood collection equipment can improve blood collection’s success rate and stability, reduce the workload of medical staff, and improve the efficiency of diagnosis and treatment. This study proposed a rigid-flexible composite puncture (RFCP) strategy, based on which a small 7-degree-of-freedom (DOF) auxiliary venipuncture blood collection (VPBC) robot using a trocar needle was designed. The robot consists of a position and orientation adjustment mechanism and a RFCP end-effector, which can perform RFCP to avoid piercing the blood vessel’s lower wall during puncture. The inverse kinematics solution and validation of the robot were analyzed based on the differential evolution algorithm, after which the quintic polynomial interpolation algorithm was applied to achieve the robot trajectory planning control. Finally, the VPBC robot prototype was developed for experiments. The trajectory planning experiment verified the correctness of the inverse kinematics solution and trajectory planning, and the composite puncture blood collection experiment verified the feasibility of the RFCP strategy.
Isolationism, instrumentalism and fiscal policy
Authors: Verbeek Bruno 
Published: March 2024

AbstractWhen reading contemporary theories of distributive justice, one could easily get the impression that questions of fiscal design are normatively speaking merely instrumental for realizing the distributive ideal. Once the overall conception of justice is settled upon, questions of how the state should arrange its institutions and policies are settled if they effectively and efficiently promote the preferred distribution. I argue that such pure instrumentalism is mistaken in the context of fiscal policy. As a result, there is nothing problematic or morally arbitrary about accepting domain-specific principles of fiscal justice.
Seeking victim-centred accountability for violence against persons with disabilities at the United Nations Independent International Commission of Inquiry for Ukraine
Authors: McInnes Kate 
Published: March 2024

AbstractPersons with disabilities suffer disproportionately in every armed conflict, and Russia’s war in Ukraine is no exception. The atrocities committed against persons with disabilities in this conflict, however, are in part a consequence of the state’s longstanding policy of institutionalization, which heightens existing vulnerabilities and places persons with disabilities at an unacceptable risk of acute harm. The Independent International Commission of Inquiry for Ukraine must investigate the extensive and varied acts of violence that have been committed against persons with disabilities in Ukraine since the beginning of the Russian invasion, with a focus on persons with disabilities who are institutionalized. In recommending future action, the Commission must be driven by a victim-centred approach to accountability that contributes both to the criminal prosecutions of individual perpetrators, and to systemic reforms that contribute to the project of deinstitutionalization. This article can assist the Commission’s analysis by: (i) canvassing the reports of violence against persons with disabilities during the war in Ukraine, particularly those persons in institutions; (ii) reviewing the Commission for Ukraine’s mandate and explaining its primary purpose – that is, to ascertain the facts of the conflict, through an intersectional lens, with the aim of promoting accountability – with reference to the work done by United Nations commissions of inquiry in the past; and (iii) providing concrete examples on how the Commission’s investigations and report can further both legal accountability and systemic accountability for violence against persons with disabilities in Ukraine.
Paramedics’ Success and Complications in Prehospital Pediatric Intubation: A Meta-Analysis
Authors: AlGhamdi Faisal A. , AlJoaib Nasser A. , Saati Abdulaziz M. , Abu Melha Mishal A. , Alkhofi Mohammad A. 
Published: March 2024

AbstractBackground:Prehospital pediatric intubation is a potentially life-saving procedure in which paramedics are relied upon. However, due to the anatomical nature of pediatrics and associated adverse events, it is more challenging compared to adult intubation. In this study, the knowledge and attitude of paramedics was assessed by measuring their overall success rate and associated complications.Methods:An online search using PubMed, Scopus, Web of Science, and Cochrane CENTRAL was conducted using relevant keywords to include studies that assess success rates and associated complications. Studies for eligibility were screened. Data were extracted from eligible studies and pooled as risk ratio (RR) with a 95% confidence interval (CI).Results:Thirty-eight studies involving 14,207 pediatrics undergoing intubation by paramedics were included in this study. The prevalence of success rate was 82.5% (95% CI, 0.745-0.832) for overall trials and 77.2% (95% CI, 0.713-0.832) success rate after the first attempt. By subgrouping the patients according to using muscle relaxants during intubation, the group that used muscle relaxants showed a high overall successful rate of 92.5% (95% CI, 0.877-0.973) and 79.9% (95% CI, 0.715-0.994) success rate after the first attempt, more than the group without muscle relaxant which represent 78.9% (95% CI, 0.745-0.832) overall success rate and 73.3% (95% CI, 0.616-0.950) success rate after first attempt.Conclusion:Paramedics have a good overall successful rate of pediatric intubation with a lower complication rate, especially when using muscle relaxants.
On Grief and Griefbots
Authors: Voinea Cristina 
Published: March 2024

AbstractGriefbots are chatbots designed to assist individuals in coping with the loss of a loved one by offering a digital replica of the departed. Navigating grief is a deeply transformative and vulnerable journey intricately tied to one's well-being. Do griefbots aid in the grieving process, or do they complicate it? To address these questions, this article blends insights from philosophy and neuroscience to explore the nature of grief as a means to clarify the ethical dimensions surrounding the use of griefbots.
Intersectional Motherhood and Candidate Evaluations in the United States
Authors: Sweet-Cushman Jennie , Bauer Nichole M. 
Published: March 2024

AbstractIn the United States, emphasizing their families and talking about parenthood can be a potent strategy for political candidates as voters use information about a candidate’s family life to make assessments of the candidate’s personal attributes and issue competencies. We nonetheless know little about how a candidate’s race affects these assessments. We thus consider how Black women use and benefit from politicizing motherhood, and we argue that the unique intersectional identities of Black women shaped jointly by their race and gender can give Black women a stronger strategic advantage from highlighting motherhood compared to white women. Using both observational and experimental data, we apply this intersectional framework by examining motherhood messages. We identify the extent to which Black women rely on messages about motherhood and how voters respond. Our results show that Black women are just as likely to use motherhood messages relative to white women, and that Black women receive positive evaluations from voters from a message emphasizing motherhood. White and minority voters are equally likely to positively rate Black women who emphasize motherhood.
Emergency department presentations for deliberate self-harm and suicidal ideation in 25–39 year olds following agency-notified child maltreatment: results from the Childhood Adversity and Lifetime Morbidity (CALM) study
Authors: Kisely S. , Bull C. , Trott M. , Arnautovska U. , Siskind D. , Warren N. , Najman J. Moses 
Published: March 2024

Abstract

Aims
To compare prospective reports of child maltreatment (CM) with emergency department (ED) presentations for deliberate self-harm (DSH) and suicidal ideation in individuals aged between 25 and 39 years old.

Methods
Linked records between the Mater-University of Queensland Study of Pregnancy birth cohort and Queensland administrative health data were used, which included notifications to child protection agencies for CM. ED presentations for individuals aged between 25 and 39 years of age for suicidal ideation, suicidal behaviour or poisoning by paracetamol or psychotropic medications where the intention was unclear were examined using logistic regression analyses.

Results
A total of 609 (10.1%) individuals were the subject of one or more CM notifications for neglect or physical, sexual or emotional abuse before the age of 15 years. Of these, 250 (4.1%) presented at least once to ED for DSH and/or suicidal ideation between 25 and 39 years of age. In adjusted analysis, any notification of CM was associated with significantly increased odds of presenting to ED for these reasons (aOR = 2.80; 95% CI = 2.04–3.84). In sensitivity analyses, any notification of CM increased the odds of the combined outcome of DSH and suicidal ideation by 275% (aOR = 2.75; 95% CI = 1.96–4.06) and increased the odds of DSH alone by 269% (aOR = 2.69; 95% CI = 1.65–4.41).

Conclusions
All CM types (including emotional abuse and neglect) were associated with ED presentations for DSH and suicidal ideation in individuals between 25 and 39 years of age. These findings have important implications for the prevention of DSH, suicidal ideation and other health outcomes. They also underscore the importance of trauma-informed care in ED for all individuals presenting with DSH and suicidal ideation.
Ross Ice Shelf Displacement and Elastic Plate Waves Induced by Whillans Ice Stream Slip Events
Authors: Wiens Douglas A. , Aster Richard C. , Nyblade Andrew A. , Bromirski Peter D. , Gerstoft Peter , Stephen Ralph A. 
Published: March 2024

AbstractIce shelves are assumed to flow steadily from their grounding lines to the ice front. We report the detection of ice‐propagating extensional Lamb (plate) waves accompanied by pulses of permanent ice shelf displacement observed by co‐located Global Navigation Satellite System receivers and seismographs on the Ross Ice Shelf. The extensional waves and associated ice shelf displacement are produced by tidally triggered basal slip events of the Whillans Ice Stream, which flows into the ice shelf. The propagation velocity of 2,800 m/s is intermediate between shear and compressional ice velocities, with velocity and particle motions consistent with predictions for extensional Lamb waves. During the passage of the Lamb waves the entire ice shelf is displaced about 60 mm with a velocity more than an order of magnitude above its long‐term flow rate. Observed displacements indicate a peak dynamic strain of 10−7, comparable to that of earthquake surface waves that trigger ice quakes.
Burial of Organic Carbon in Swedish Fjord Sediments: Highlighting the Importance of Sediment Accumulation Rate in Relation to Fjord Redox Conditions
Authors: Watts Emily G. , Hylén Astrid , Hall Per O. J. , Eriksson Mats , Robertson Elizabeth K. , Kenney William F. , Bianchi Thomas S. 
Published: March 2024

AbstractFjords are net carbon sinks with high organic carbon (OC) burial rates; however, the key drivers of OC burial in these systems are not well constrained. To study the role of water column redox condition and OC composition on OC preservation in fjord sediments, we determined OC accumulation rates (OCAR), OC source, and OC degradation in three Swedish fjords with variable redox conditions (long‐term oxic, seasonally hypoxic, and long‐term anoxic). Average OCARs were variable between and within the fjords studied (2–122 g OC m−2 yr−1), but highest rates were at the mouth for each fjord. Based on a δ13C mixing model, Swedish fjords bury predominantly marine‐derived OC (∼83% of the total OC burial) likely because of relatively gentle slopes, low riverine discharge, and high marine inflow. Using a multi‐biomarker approach (lignin, photosynthetic pigments, and total hydrolyzable amino acids) we found, terrestrially‐ and marine‐derived OC were moderately degraded under the various redox conditions sampled, suggesting water column redox and OC source are not primary drivers of OC burial in these fjords. Rather, high sediment accumulation rates, common to fjords globally, lead to low oxygen exposure times, thus promoting efficient burial of OC regardless of its chemical composition.
Calorie restriction-induced leptin reduction and T-lymphocyte activation in blood and adipose tissue in men with overweight and obesity
Authors: Travers Rebecca L. , Trim William V. , Motta Alexandre C. , Betts James A. , Thompson Dylan 
Published: March 2024

Abstract
Background
T-Lymphocyte activation is modulated by the adipokine leptin and serum concentrations of this hormone can be reduced with short-term calorie restriction. The aim of this study was to understand whether leptin per se is important in determining levels of T-lymphocyte activation in humans, by investigating whether the reduction in leptin concentration following calorie restriction is associated with a decrease in T-Lymphocyte activation in blood and adipose tissue.

Methods
Twelve men with overweight and obesity (age 35–55 years, waist circumference 95–115 cm) reduced their calorie intake by 50% for 3 consecutive days. Blood and subcutaneous adipose tissue were obtained for isolation of immune cells and cytokine analysis. CD4+ and CD8 + T-Lymphocytes were identified and characterised according to their expression of activation markers CD25 and CD69 by flow cytometry.

Results
Serum leptin was reduced by (mean ± SEM) 31 ± 16% (p < 0.001) following calorie restriction. The percentage of blood CD4 + CD25 + T-lymphocytes and level of CD25 expression on these lymphocytes were significantly reduced by 8 ± 10% (p = 0.016) and 8 ± 4% (p = 0.058), respectively. After calorie restriction, ex vivo leptin secretion from abdominal subcutaneous adipose tissue explants was not changed, and this corresponded with a lack of change in adipose tissue resident T-Lymphocyte activation.

Conclusions
Serum leptin was reduced after calorie restriction and this was temporally associated with a reduction in activation of blood CD4 + CD25 + T-Lymphocytes. In abdominal subcutaneous adipose tissue, however, leptin secretion was unaltered, and there were no observed changes in adipose resident T-Lymphocyte activation.
Methylation analysis of DCC gene in saliva samples is an efficient method for non-invasive detection of superficial hypopharyngeal cancer
Authors: Hirai Ryosuke , Kinugasa Hideaki , Yamamoto Shumpei , Ako Soichiro , Tsutsumi Koichiro , Abe Makoto , Miyahara Koji , Nakagawa Masahiro , Otsuka Motoyuki 
Published: March 2024

Abstract
Background
Advances in upper gastrointestinal endoscopic technology have enabled early detection and treatment of hypopharyngeal cancer. However, in-depth pharyngeal observations require sedation and are invasive. It is important to establish a minimally invasive and simple evaluation method to identify high-risk patients.

Methods
Eighty-seven patients with superficial hypopharyngeal cancer and 51 healthy controls were recruited. We assessed the methylation status of DCC, PTGDR1, EDNRB, and ECAD, in tissue and saliva samples and verified the diagnostic accuracy by methylation analyses of their promoter regions using quantitative methylation-specific PCR.

Results
Significant differences between cancer and their surrounding non-cancerous tissues were observed in the methylation values of DCC (p = 0.003), EDNRB (p = 0.001), and ECAD (p = 0.043). Using receiver operating characteristic analyses of the methylation values in saliva samples, DCC showed the highest area under the curve values for the detection of superficial hypopharyngeal cancer (0.917, 95% confidence interval = 0.864–0.970), compared with those for EDNRB (0.680) and ECAD (0.639). When the cutoff for the methylation values of DCC was set at ≥0.163, the sensitivity to detect hypopharyngeal cancer was 82.8% and the specificity was 90.2%.

Conclusions
DCC methylation in saliva samples could be a non-invasive and efficient tool for early detection of hypopharyngeal cancer in high-risk patients.
New technologies developed for treatment of premature ejaculation
Authors: Shechter Arik , Gruenwald Ilan 
Published: March 2024

AbstractPremature ejaculation (PE), lifelong and acquired, is the most common male sexual disorder, with serious impacts on the patient and his partner’s quality of life, sexual well-being, and psychosocial health. The most popular treatment options are on-demand topical anesthetics and off-label daily or on-demand selective serotonin reuptake inhibitors (SSRIs), followed by behavioral therapy. While SSRI treatments are reportedly safe, they are associated with limited efficacy and provide only a temporary delay in ejaculation latency time. The majority of PE patients are dissatisfied with SSRIs; thus, adherence to on-demand or daily SSRI treatments is low. In this article, we review studies on currently available technologies that are not pharmacological, surgical, cognitive or behavioral therapies. Recent data from studies of newly developed medical devices used in PE treatment are encouraging as they provide drug-free spontaneity during coitus, without severe adverse effects.
Creation of flexible spin-caloritronic material with giant transverse thermoelectric conversion by nanostructure engineering
Authors: Gautam Ravi , Hirai Takamasa , Alasli Abdulkareem , Nagano Hosei , Ohkubo Tadakatsu , Uchida Ken-ichi , Sepehri-Amin Hossein 
Published: March 2024

AbstractFunctional materials such as magnetic, thermoelectric, and battery materials have been revolutionized through nanostructure engineering. However, spin caloritronics, an advancing field based on spintronics and thermoelectrics with fundamental physics studies, has focused only on uniform materials without complex microstructures. Here, we show how nanostructure engineering enables transforming simple magnetic alloys into spin-caloritronic materials displaying significantly large transverse thermoelectric conversion properties. The anomalous Nernst effect, a promising transverse thermoelectric phenomenon for energy harvesting and heat sensing, has been challenging to utilize due to the scarcity of materials with large anomalous Nernst coefficients. We demonstrate a remarkable ~ 70% improvement in the anomalous Nernst coefficients (reaching ~ 3.7 µVK−1) and a significant ~ 200% enhancement in the power factor (reaching ~ 7.7 µWm−1K−2) in flexible Fe-based amorphous materials by nanostructure engineering without changing their composition. This surpasses all reported amorphous alloys and is comparable to single crystals showing large anomalous Nernst effect. The enhancement is attributed to Cu nano-clustering, facilitating efficient transverse thermoelectric conversion. This discovery advances the materials science of spin caloritronics, opening new avenues for designing high-performance transverse thermoelectric devices for practical applications.
Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures
Authors: Hu Jinjian , Xia Wencheng , Zeng Shuyi , Lim Yeh-Jun , Tao Youqi , Sun Yunpeng , Zhao Lang , Wang Haosen , Le Weidong , Li Dan , Zhang Shengnan , Liu Cong , Li Yan-Mei 
Published: March 2024

Abstractα-Synuclein forms amyloid fibrils that are critical in the progression of Parkinson’s disease and serves as the pathological hallmark of this condition. Different posttranslational modifications have been identified at multiple sites of α-synuclein, influencing its conformation, aggregation and function. Here, we investigate how disease-related phosphorylation and O-GlcNAcylation at the same α-synuclein site (S87) affect fibril structure and neuropathology. Using semi-synthesis, we obtained homogenous α-synuclein monomer with site-specific phosphorylation (pS87) and O-GlcNAcylation (gS87) at S87, respectively. Cryo-EM revealed that pS87 and gS87 α-synuclein form two distinct fibril structures. The GlcNAc situated at S87 establishes interactions with K80 and E61, inducing a unique iron-like fold with the GlcNAc molecule on the iron handle. Phosphorylation at the same site prevents a lengthy C-terminal region including residues 73 to 140 from incorporating into the fibril core due to electrostatic repulsion. Instead, the N-terminal half of the fibril (1–72) takes on an arch-like fibril structure. We further show that both pS87 and gS87 α-synuclein fibrils display reduced neurotoxicity and propagation activity compared with unmodified α-synuclein fibrils. Our findings demonstrate that different posttranslational modifications at the same site can produce distinct fibril structures, which emphasizes link between posttranslational modifications and amyloid fibril formation and pathology.
Developmental timing in plants
Authors: Coen Enrico , Prusinkiewicz Przemyslaw 
Published: March 2024

AbstractPlants exhibit reproducible timing of developmental events at multiple scales, from switches in cell identity to maturation of the whole plant. Control of developmental timing likely evolved for similar reasons that humans invented clocks: to coordinate events. However, whereas clocks are designed to run independently of conditions, plant developmental timing is strongly dependent on growth and environment. Using simplified models to convey key concepts, we review how growth-dependent and inherent timing mechanisms interact with the environment to control cyclical and progressive developmental transitions in plants.