bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural correlates of emotional processing in trauma-related narratives
Authors: Cao Minne , Zhu Shengnan , Tang Enze , Xue Chuang , Li Kun , Yu Hua , Zhong Tao , Li Tao , Chen Hui , Deng Wei 
Published: February 2025

Abstract

Background
Post-traumatic stress disorder (PTSD) is a mental health condition caused by the dysregulation or overgeneralization of memories related to traumatic events. Investigating the interplay between explicit narrative and implicit emotional memory contributes to a better understanding of the mechanisms underlying PTSD.

Methods
This case–control study focused on two groups: unmedicated patients with PTSD and a trauma-exposed control (TEC) group who did not develop PTSD. Experiments included real-time measurements of blood oxygenation changes using functional near-infrared spectroscopy during trauma narration and processing of emotional and linguistic data through natural language processing (NLP).

Results
Real-time fNIRS monitoring showed that PTSD patients (mean [SD] Oxy-Hb activation, 0.153 [0.084], 95% CI 0.124 to 0.182) had significantly higher brain activity in the left anterior medial prefrontal cortex (L-amPFC) within 10 s after expressing negative emotional words compared with the control group (0.047 [0.026], 95% CI 0.038 to 0.056; p < 0.001). In the control group, there was a significant time-series correlation between the use of negative emotional memory words and activation of the L-amPFC (latency 3.82 s, slope = 0.0067, peak value = 0.184, difference = 0.273; Spearman’s r = 0.727, p < 0.001). In contrast, the left anterior cingulate prefrontal cortex of PTSD patients remained in a state of high activation (peak value = 0.153, difference = 0.084) with no apparent latency period.

Conclusions
PTSD patients display overactivity in pathways associated with rapid emotional responses and diminished regulation in cognitive processing areas. Interventions targeting these pathways may alleviate symptoms of PTSD.
Implicit neural sensitivity for negatively valued social and non-social visual scenes in young adults exposed to childhood adversity
Authors: Qiao Zhiling , Van der Donck Stephanie , Mazereel Victor , Jennen Lise , Samaey Celine , Vancampfort Davy , van Winkel Ruud , Boets Bart 
Published: February 2025

Abstract

Background
Based on facial expression experiments, childhood adversity may be associated with threat-related information processing bias. Yet, it is unclear whether this generalizes to other threat-related stimuli, such as social and non-social visual scenes.

Methods
We combined fast periodic visual stimulation with frequency-tagging electroencephalography (EEG) and eye-tracking to assess automatic and implicit neural discrimination, neural salience and preferential looking towards negative versus neutral social and non-social visual scenes in young adults aged 16–24 years (51 with childhood adversity and psychiatric symptoms and 43 controls).

Results
Controls showed enhanced negative-neutral neural discrimination within a social versus non-social context. However, this facilitating effect of social content was absent in those with adversity, suggesting a selective alteration in social threat processing. Moreover, individual differences in adversity severity, and more specifically threat experiences (but not neglect experiences), were associated with decreased neural discrimination of negative versus neutral social scenes, corresponding to similar findings in facial expression processing, indicating the robustness of adversity-related deficits in threat-safety discrimination across social visual stimuli.

Conclusions
The adversity-related decreased threat-safety discrimination might impact individuals’ perception of social cues in daily life and relate to poor social functioning and future development of psychopathology.
Overcoming the agglomeration paradox: skill-dependent FDI and urbanization in China
Authors: Vortherms Samantha A. 
Published: February 2025

Abstract
The influx of foreign capital into cities in developing countries creates new labor demands, triggering significant internal migration as workers move for opportunities. But this mobilization creates a management problem for local governments. How do local officials manage competing interests in developing their labor market while preventing governance problems from excessive demand on public resources? Using the highly institutionalized case of China, I argue that local governments encourage long-term migration of “desirable” migrants by integrating them into social services while keeping others out. Variation in locally invested FDI skill dependence drives variation in inclusivity towards internal migrants. Policies that facilitate the integration of internal migrants into local urban welfare systems correlate with investment in firms with greater dependence on high-skilled workers, especially when investment flows to firms established more than one year previously. These trends are strongest in eastern municipalities where market forces play a larger role in local development policies.
Empirical Models of Shallow Groundwater and Multi‐Hazard Flood Forecasts as Sea‐Levels Rise
Authors: Cox Simon C. , Ettema Marc H. J. , Chambers Lee A. , Stephens Scott A. , Bodeker Gregory E. , Nguyen Quyen , Diaz‐Rainey Ivan , Moore Antoni B. 
Published: February 2025

AbstractKnowledge of coastal hydrogeology and hazards as groundwater responds to sea‐level rise (SLR) can be improved through installation of shallow groundwater monitoring piezometers and continuous observations. Interpolation of site data enables mapping of the present‐day state of groundwater elevation, depth to groundwater (DTW), their temporal statistical variation, and differing spatial responses to tides and rainfall. Future DTW and its variability can be projected under increments of SLR, with assumptions and caveats, to show where and when episodic and/or permanent inundation can be expected. This methodology is outlined in a case study of Dunedin, New Zealand, which enabled comparison of rising groundwater's contribution to pluvial flooding and groundwater emergence with coastal inundation. Changes in relative land exposure with SLR shows evolution in flood hazard from current pluvial‐dominated events, into “flooding from below” and groundwater emergence, in advance of any overland coastal inundation. Dunedin exemplifies how groundwater transfers effects of SLR surprisingly far inland, but the lowest‐lying or shoreline‐proximal suburbs are not necessarily the most vulnerable. Unlike coastal inundation, rising groundwater is unconstrained by protective topography and presents as a creeping hazard, or contributor to hazards such as pluvial flooding, which can be widespread, occurring already and difficult to defend against. The empirical models contain assumptions and uncertainties important to the veracity of results and application. While conservative (“risk averse”) and a compromise from computationally expensive numerical solutions, their value is in providing the spatial and temporal precision needed for multi‐source hazard assessment and holistic adaptive planning.
En‐échelon Rifting and Origin of the Volcanism in the Comoros
Authors: Boymond P. , Feuillet N. , Thinon I. , Scholtès L. , Zaragosi S. , Leroy S. , Lemoine A. 
Published: February 2025

AbstractTwo volcanic provinces have been recently discovered during the SISMAORE oceanographic cruise in the Comoros archipelago in the North Mozambique Channel between Madagascar and East Africa: N’Droundé, along the North‐eastern insular slopes of Grande Comores Island and Mwezi, in the abyssal plain, north‐east of Mayotte and Anjouan islands. By combining bathymetry and backscatter data, high‐resolution seismic reflection and sub‐bottom profiles, we have identified and mapped various tectonic (faults, forced folds) and volcanic structures (lava flows, edifices, sills, dykes) at several spatial scales on the seabed and in cross‐section within the sedimentary cover. We have characterized the volcano‐tectonic structures (geometry, segmentation, and kinematics) to better understand the link (geometry, chronology) between tectonic and volcanic processes. We show that volcanic and tectonic features are controlled by tectonic processes and vice‐versa. Ridges, volcanic cones and lava flows are set up along fissures and dikes during main rifting events to accommodate a N40°E regional extension within an E‐W right lateral shear transfer zone. The volcano tectonic features are Plio‐Pleistocene. This transfer zone lies between the offshore branch of the East African rift system and Malagasy grabens and may have formed when the East African rifts propagated offshore. We evidence a major rifting episode in the last Ma. The estimated volume and flux of extruded lavas show that the volcanism of the Comoros could be related to shallow tectonic processes.
Short‐Period Flapping Motion of Current Sheet in Saturn's Magnetosphere
Authors: Xu S. B. , Huang S. Y. , Yuan Z. G. , Jiang K. , Wu H. H. , Zhang J. , Wang Z. , Xiong Q. Y. , Lin R. T. 
Published: February 2025

AbstractThe flapping motion of the current sheet is a common dynamic phenomenon in the planetary magnetosphere and plays an important role in the transportation of energy and disturbances. Based on the measurements from the Cassini spacecraft, we investigate the short‐period flapping motions of the current sheet characterized by periods significantly much smaller than the planetary rotation cycle in Saturn's magnetosphere. Employing the Minimum Variance Analysis (MVA) method, a new technique is developed to distinguish the propagation of current sheet flapping in the radial and azimuthal directions. A total of 105 short‐period current sheet flapping events have been detected in Saturn's magnetosphere. The global spatial distribution of these events is provided, and their respective propagation directions have been identified. Further discussions are conducted on the potential sources of the short‐period current sheet flapping in Saturn's magnetosphere, including magnetic reconnection, Titan, fast plasma flow, planetary period oscillations, and instabilities near the magnetopause.
Diverse Altitudinal Patterns and Drivers of Greenhouse Gas Dynamics in Southwest China Alpine Streams and Rivers
Authors: Wang Ying , Li Yuhao , Wang Genxu , Li Yang , Sun Xiangyang , Wang Wenzhi , Song Chunlin 
Published: February 2025

AbstractStreams and rivers are globally significant sources of greenhouse gases (GHGs) to the atmosphere. However, GHG evasion from mountain streams remains poorly constrained due to scarce data. In this study, we measured concentrations and estimated fluxes of riverine carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O) across three alpine catchments in Southwest China. GHG concentrations in these turbulent streams and rivers are slightly oversaturated but much lower than the global average, likely due to high gas transfer velocities that rapidly deplete GHGs. Headwater streams (first‐order) exhibited higher gas evasion rates than large rivers (fourth‐order), despite having lower CO2 and N2O concentrations. The partial pressure of CO2 and dissolved N2O concentrations decreased linearly with elevation, likely linked to the altitudinal patterns of forest cover and groundwater table depth. Dissolved CH4 concentrations and the three GHGs fluxes showed weak relationships with elevation. We observed significant seasonal differences in GHG fluxes, with higher evasion rates during the wet season. The seasonal and spatial heterogeneity in stream GHG concentrations and fluxes was primarily controlled by hydrology, climate, and geomorphology. Our analyses also revealed that GHG fluxes were positively correlated with stream water temperature, velocity, and channel slope. This study demonstrates that these alpine streams are underestimated net sources of GHGs, particularly CO2 and N2O, highlighting the importance of mountain headwater systems in regional and global GHG budgets. The diverse altitudinal patterns of GHG dynamics also suggest complex controls of GHG in alpine streams and rivers.
A Buried Columbia‐Forming Orogen Front Located in the Northwestern North China Craton
Authors: Tian Gang , Yang Minghui , Ma Li , Song Lijun , Wen Xiaogang , Xue Haijun , Jia Huichong , Pu Renhai , Chen Jie , Chen Shuo 
Published: February 2025

AbstractThe Inner Mongolia Suture Zone (IMSZ) in the North China Craton is an important component of the Colombia‐forming orogen, and its southern may have preserved the deformation relics of the ancient orogen front due to being prolonged buried beneath the Ordos Basin. Here we used the high‐resolution seismic profiles in the North Ordos Basin and U‐Pb zircon age data from the borehole basement samples to discover the existence of wedge tectonics consisting of thrust belt and ramp structure within the basement and to fingerprint markedly different basement ages on both sides of the Thrust Front Belt (TFB). The footwall rocks (∼2.2–1.95 Ga) have a dominant affinity with the south‐central Ordos Block (OB), while the hanging wall rocks (∼2.51–2.46 Ga) have no immediate affinity with the OB, possibly representing a set of late Neoarchean‐early Paleoproterozoic island arc formations developed in the northern margin of the OB (termed the Hangjinqi Terrane). So our preferred interpretation posits that the wedge tectonics was formed by wedging the OB into the underthrusting Hangjinqi Terrane during the ∼1.95 Ga collision between the Yinshan Block and OB, with the TFB demarcated as the tectonic boundary separating the OB and IMSZ. This wedge tectonics in the late Paleoproterozoic orogen flank bears a striking resemblance to crustal structures in Phanerozoic orogenic settings, suggesting that this orogenesis mode of crustal deformation has been initiated at least in the Orosirian and may have been a significant orogen mode for the assembly of the Columbia supercontinent.
NF-κB RelB suppresses the inflammatory gene expression programs of dendritic cells by competing with RelA for binding to target gene promoters
Authors: Navarro Héctor I. , Daly Allison E. , Rodriguez Benancio , Wu Sunny , Ngo Kim A. , Fraser Anna , Schiffman Allison , Liu Yi , Smale Stephen T. , Chia Jennifer J. , Hoffmann Alexander 
Published: February 2025

Abstract
A group of autoinflammatory disorders termed relopathies arise as a consequence of NF-κB dysregulation. Genetic loss of the NF-κB subunit RelB in humans and mice leads to autoimmunity and lethal multi-organ inflammatory pathology. Our recent study showed that this inflammatory pathology is independent of type I interferon signaling, and further identified dysregulation of a set of pro-inflammatory NF-κB target genes. However, it remains unknown how the loss of RelB leads to the dysregulation of these NF-κB motif-containing pro-inflammatory genes. Here, we report epigenome profiling studies revealing that RelB is associated with pro-inflammatory genes in dendritic cells. While these genes recruit RelA binding upon exposure to a maturation stimulus, we observed substantially more RelA recruitment in the absence of RelB. For these genes, we found that elevated RelA recruitment is correlated with elevated gene expression. To test whether RelB may compete with RelA for binding to NF-κB-regulated gene promoters via competition for κB sites, we generated a new mouse strain (RelB

DB/DB
) that harbors targeted point mutations in the RelB DNA binding domain that eliminates high-affinity DNA binding. We found that this targeted mutation in the RelB DNA binding domain is sufficient to drive multi-organ inflammatory pathology. These results provide insights into the biological mechanism of RelB as a suppressor of pro-inflammatory gene expression and autoimmune pathology.
Accelerated epigenetic aging in Huntington’s disease involves polycomb repressive complex 1
Authors: Brulé Baptiste , Alcalá-Vida Rafael , Penaud Noémie , Scuto Jil , Mounier Coline , Seguin Jonathan , Khodaverdian Sina Vincent , Cosquer Brigitte , Birmelé Etienne , Le Gras Stéphanie , Decraene Charles , Boutillier Anne-Laurence , Merienne Karine 
Published: February 2025

Abstract
Loss of epigenetic information during physiological aging compromises cellular identity, leading to de-repression of developmental genes. Here, we assessed the epigenomic landscape of vulnerable neurons in two reference mouse models of Huntington neurodegenerative disease (HD), using cell-type-specific multi-omics, including temporal analysis at three disease stages via FANS-CUT&Tag. We show accelerated de-repression of developmental genes in HD striatal neurons, involving histone re-acetylation and depletion of H2AK119 ubiquitination and H3K27 trimethylation marks, which are catalyzed by polycomb repressive complexes 1 and 2 (PRC1 and PRC2), respectively. We further identify a PRC1-dependent subcluster of bivalent developmental transcription factors that is re-activated in HD striatal neurons. This mechanism likely involves progressive paralog switching between PRC1-CBX genes, which promotes the upregulation of normally low-expressed PRC1-CBX2/4/8 isoforms in striatal neurons, alongside the down-regulation of predominant PRC1-CBX isoforms in these cells (e.g., CBX6/7). Collectively, our data provide evidence for PRC1-dependent accelerated epigenetic aging in HD vulnerable neurons.
Double-strand break repair pathways differentially affect processing and transduction by dual AAV vectors
Authors: Maurer Anna C. , Benyamini Brian , Whitney Oscar N. , Fan Vinson B. , Cattoglio Claudia , Kissiov Djem U. , Dailey Gina M. , Darzacq Xavier , Weitzman Matthew D. , Tjian Robert 
Published: February 2025

Abstract
Recombinant adeno-associated viral vectors (rAAV) are a powerful tool for gene delivery but have a limited DNA carrying capacity. Efforts to expand this genetic payload have focused on engineering the vector components, such as dual trans-splicing vectors which double the delivery size by exploiting the natural concatenation of rAAV genomes in host nuclei. We hypothesized that inefficient dual vector transduction could be improved by modulating host factors which affect concatenation. Since factors mediating concatenation are not well defined, we performed a genome-wide screen to identify host cell regulators. We discover that Homologous Recombination (HR) is inhibitory to dual vector transduction. We demonstrate that depletion or inhibition of HR factors BRCA1 and Rad51 significantly increase reconstitution of a large split transgene by increasing both concatenation and expression from rAAVs. Our results define roles for DNA damage repair in rAAV transduction and highlight the potential for pharmacological intervention to increase genetic payload of rAAV vectors.
Holographic tomographic volumetric additive manufacturing
Authors: Álvarez-Castaño Maria Isabel , Madsen Andreas Gejl , Madrid-Wolff Jorge , Sgarminato Viola , Boniface Antoine , Glückstad Jesper , Moser Christophe 
Published: February 2025

Abstract
Several 3D light-based printing technologies have been developed that rely on the photopolymerization of liquid resins. A recent method, so-called Tomographic Volumetric Additive Manufacturing, allows the fabrication of microscale objects within tens of seconds without the need for support structures. This method works by projecting intensity patterns, computed via a reverse tomography algorithm, into a photocurable resin from different angles to produce a desired 3D shape when the resin reaches the polymerization threshold. Printing using incoherent light patterning has been previously demonstrated. In this work, we show that a light engine with holographic phase modulation unlocks new potential for volumetric printing. The light projection efficiency is improved by at least a factor 20 over amplitude coding with diffraction-limited resolution and its flexibility allows precise light control across the entire printing volume. We show that computer-generated holograms implemented with tiled holograms and point-spread-function shaping mitigates the speckle noise which enables the fabrication of millimetric 3D objects exhibiting negative features of 31 μm in less than a minute with a 40 mW light source in acrylates and scattering materials, such as soft cell-laden hydrogels, with a concentration of 0.5 million cells per mL.
Numerical modeling of oxygen diffusion in tissue spheroids undergoing fusion using function representation and finite volumes
Authors: Vilinski-Mazur Katherine , Kirillov Bogdan , Rogozin Oleg , Kolomenskiy Dmitry 
Published: February 2025

Abstract
A three-dimensional cell culture called a spheroid serves as a foundational entity in a wide variety of modern tissue engineering applications, including 3D-bioprinting and preclinical drug testing. Lack of oxygen within tissue spheroids hinders metabolism of cells and eventually leads to cell death. Prevention of necrosis is crucial to success of tissue engineering methods and such prevention requires estimation of cell viability in the spheroid. We propose a novel approach for numerical modeling of diffusion in tissue spheroids during their fusion. The approach is based on numerical solutions of partial differential equations and the application of Function Representation (FRep) framework for geometric modeling. We present modeling of oxygen diffusion based on meshes derived from the geometry of fusing spheroids, a method for selecting optimal spheroid size, and several statistics for estimating cellular viability. Our findings provide insights into oxygen diffusion in three-dimensional cell cultures thus improving the robustness of biotechnological methods that employ tissue spheroids.
Effects of combined application of slow-release nitrogen fertilizer and urea on nitrogen uptake, utilization and yield of maize under two tillage methods
Authors: Fan Mingyuan , Chen Pei , Zhang Chang , Liang Min , Xie Guangming , Zhao Li , Wang Chuangyun 
Published: February 2025

Abstract
Corn is one of the important food crops in the world, in order to pursue high yield and high efficiency, the input of chemical fertilizer has been continuously increased, which has led to the decline of fertilizer utilization rate, environmental pollution and other problems, and the slow-release fertilizer has attracted much attention because of its nutrient characteristics, but the high price limits its wide application;On the other hand, long-term rotary tillage will lead to the shallowness of the soil tillage layer and the increase of the bulk density of the deep soil, and subsoiling can effectively break the bottom layer of the soil plough and reduce the bulk density of the soil. Therefore, in this study, Qiangsheng 388 was used as the experimental material, and under rotary tillage (R) and rotary tillage + subsoiling (R+S), CK (no fertilization), U (100% nitrogen fertilizer), S (100% slow-release fertilizer) and different UNS ratios (nitrogen fertilizer and slow-release fertilizer) were used for two years in field experiments to explore the effects of slow-release fertilizer and urea on soil water use efficiency, dry matter accumulation, nitrogen uptake and utilization, operation and yield under the two tillage methods. The results showed that compared with CK, U and S, UNS significantly improved water use efficiency, dry matter accumulation, nitrogen uptake, operation and yield. Among them, UNS2 (the ratio of S and U was 7:3) was the best. In 2022, R UNS2 had the best water use efficiency, dry matter accumulation, nitrogen uptake, operation and yield, which were 5.05%, 2.0%, 3.88%, 6.18% and 4.06% higher than those of R + S UNS2, respectively. In 2023, R + S UNS2 had the best treatment, which was 1.98%, 2.52%, 1.85%, 2.60% and 2.20% higher than that of R UNS2, respectively. R + S tillage can effectively improve maize yield, nitrogen uptake and utilization, water use and dry matter accumulation; Nitrogen application treatment UNS2 treatment was the best. In summary, R + S UNS2 is the best coordination strategy.