bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine Learning May Be an Alternative to BIPSS in the Differential Diagnosis of ACTH-dependent Cushing Syndrome
Authors: Demir Ahmet Numan , Ayata Deger , Oz Ahmet , Sulu Cem , Kara Zehra , Sahin Serdar , Ozaydin Dilan , Korkmazer Bora , Arslan Serdar , Kizilkilic Osman , Ciftci Sema , Celik Ozlem , Ozkaya Hande Mefkure , Tanriover Necmettin , Gazioglu Nurperi , Kadioglu Pinar 
Published: March 2024

Abstract

Context
Artificial intelligence research in the field of neuroendocrinology has accelerated. It is possible to develop noninvasive, easy-to-use and cost-effective procedures that can replace invasive procedures for the differential diagnosis of adrenocorticotropin (ACTH)-dependent Cushing syndrome (CS) by artificial intelligence.

Objective
This study aimed to develop machine-learning (ML) algorithms for the differential diagnosis of ACTH-dependent CS based on biochemical and radiological features.

Methods
Logistic regression algorithms were used for ML, and the area under the receiver operating characteristics curve was used to measure performance. We used Shapley contributed comments (SHAP) values, which help explain the results of the ML models to identify the meaning of each feature and facilitate interpretation.

Results
A total of 106 patients, 80 with Cushing disease (CD) and 26 with ectopic ACTH syndrome (EAS), were enrolled in the study. The ML task was created to classify patients with ACTH-dependent CS into CD and EAS. The average AUROC value obtained in the cross-validation of the logistic regression model created for the classification task was 0.850. The diagnostic accuracy of the algorithm was 86%. The SHAP values indicated that the most important determinants for the model were the 2-day 2-mg dexamethasone suppression test, greater than 50% suppression in the 8-mg high-dose dexamethasone test, late-night salivary cortisol, and the diameter of the pituitary adenoma. We have also made our algorithm available to all clinicians via a user-friendly interface.

Conclusion
ML algorithms have the potential to serve as an alternative decision-support tool to invasive procedures in the differential diagnosis of ACTH-dependent CS.
Teriparatide as Treatment for Severe Osteoporosis in Lung Transplant Recipients
Authors: Raven Lisa M , Goodall Louise , Center Jacqueline R , Muir Christopher A 
Published: March 2024

Abstract
Osteoporosis and osteopenia are common in lung transplant (LTx) recipients, with a significantly increased incidence compared to other non-lung solid organ transplant patients. Despite high fracture rates, including in patients treated with antiresorptive medications, there are limited data on the use of anabolic treatments in LTx recipients. We present clinical, biochemical and bone mineral density data for 3 patients with severe osteoporosis treated with teriparatide 20 micrograms daily for 18 months post-LTx. Prednisone doses ranged between 5 and 10 mg daily throughout the treatment period. All patients had previously received zoledronate (last dose 12-24 months prior to teriparatide). Bone turnover was monitored repeatedly during treatment in one patient. Following completion of teriparatide, all patients received consolidation treatment with 4 mg zoledronate. Bone density was measured prior and within 6 to 12 months after completion of teriparatide. All 3 patients experienced an increase in bone density at the lumbar spine (median +12%; range, 2%-14%) and total proximal femur (median +8%, range, 8%-10%). No adverse effects were observed. Given that severe osteoporosis is highly prevalent in LTx patients, teriparatide should be further studied as a treatment in this clinical setting. Our cases suggest it is safe and effective.
Infantile Hypothalamic Hamartoma: A Rare Presentation of Isolated Obesity
Authors: Tsumori Mika , Itonaga Tomoyo , Oyake Momoko , Hirano Naoki , Oyama Noriko , Ihara Kenji 
Published: March 2024

Abstract
Hypothalamic hamartomas (HHs) are rare, benign brain tumors or lesions of the hypothalamus that are predominantly identified in cases of epilepsy and central precocious puberty (CPP), whereas isolated manifestations of infantile obesity are atypical. We herein report an 8-month-old boy with severe obesity (Kaup index 26.4 [&gt;100th percentile]) and uncontrollable hyperphagia. His growth chart demonstrated remarkable weight gain that exceeded the length gain in magnitude. Brain magnetic resonance imaging identified a lesion consistent with HH. There were no episodes or clinical findings of epilepsy, CPP, or Cushing disease. Hypothalamic obesity should be considered in the diagnosis even in infants with excessive weight gain due to overeating.
Can routine assessment of older people’s mental health lead to improved outcomes: A regression discontinuity analysis
Authors: Baird Kalpita , Byrne Ailish , Cockayne Sarah , Cunningham-Burley Rachel , Fairhurst Caroline , Adamson Joy , Vernon Wesley , Torgerson David J. ,   on behalf of the REFORM trial
Published: March 2024

Objective
To assess whether case finding for depression among people aged 65 and above improves mental health.

Design
Opportunistic evaluation using a regression discontinuity analysis with data from a randomised controlled trial.

Setting
The REFORM trial, a falls prevention study that recruited patients from NHS podiatry clinics.

Participants
1010 community-dwelling adults over the age of 65 with at least one risk factor for falling (recent previous fall or fear of falling).

Intervention
Letter sent to patient’s General Practitioner if they scored 10 points or above on the 15-item Geriatric Depression Scale (GDS-15) informing them of the patient’s risk of depression.

Main outcome measure
GDS-15 score six months after initial completion of GDS-15.

Results
895 (88.6%) of the 1010 participants randomised into REFORM had a valid baseline and six-month GDS-15 score and were included in this study. The mean GDS-15 baseline score was 3.5 (SD 3.0, median 3.0, range 0–15); 639 (71.4%) scored 0–4, 204 (22.8%) scored 5–9 indicating mild depression, and 52 (5.8%) scored 10 or higher indicating severe depression. At six months follow-up, those scoring 10 points or higher at baseline had, on average, a reduction of 1.08 points on the GDS-15 scale (95% confidence interval -1.83 to -0.33, p = 0.005) compared to those scoring less than 10, using the simplest linear regression model.

Conclusion
Case finding of depression in podiatry patients based on a GDS-15 score of 10 or more followed by a letter to their General Practitioner significantly reduced depression severity. Whether this applies to all older patients in primary care is unknown. Further research is required to confirm these findings. Regression discontinuity analyses could be prespecified and embedded within other existing research studies.
Canadian Critical Luxury Studies: Decentring Luxury, Jessica P. Clark and Nigel Lezama (eds) (2022)
Authors: Delgado Henry Navarro 
Published: March 2024

Review of: Canadian Critical Luxury Studies: Decentring Luxury, Jessica P. Clark and Nigel Lezama (eds) (2022)
Bristol: Intellect Ltd, 248 pp.,
ISBN 978-1-78938-515-1, h/bk, $93.84
ISBN 978-1-78938-517-5, e-book, $80.00
Estado do conhecimento sobre iniciação científica na educação básica
Authors: Oliveira Victor Hugo Nedel Oliveira , Vasques Daniel Giordani 
Published: March 2024

A Iniciação Científica presente na escola básica configura-se como importante espaço de construção de conhecimentos relacionados ao campo da ciência, do método científico e da produção de saberes nas mais variadas áreas da ciência. O principal objetivo da presente investigação foi construir um estado do conhecimento sobre Iniciação Científica na educação básica. Para tanto, realizou-se pesquisa bibliográfica em formato de estado do conhecimento, com recorte temporal adotado entre os anos de 2010-2020, tendo sido selecionadas as bases de dados: IBICT (para teses e dissertações); Google Acadêmico e Scielo (para artigos científicos). Os descritores para composição do corpus da pesquisa foram: “Pesquisa”; “Iniciação Científica”; “Escola”; “Educação Básica”; “Iniciação Científica Júnior”. Os resultados demonstraram a presença de 18 artigos científicos, 05 dissertações e 05 teses. A análise descritiva demonstrou a concentração dos estudos na região concentrada Sul-Sudeste, bem como a recorrência das universidades federais na sua produção. A maior parte dos estudos contou com análise documental, seguida de entrevistas e observações, como recursos de coleta de dados. As conclusões dos estudos apresentaram as potencialidades da IC na formação e motivação dos estudantes, mas também ressaltaram preocupação com a formação pedagógica docente, bem como suscitaram reflexões sobre a importância da educação científica na contemporaneidade. É possível considerar, portanto, que a presença de práticas de Iniciação Científica na educação básica colabora significativamente na formação critica e cidadã dos estudantes, fomentando o debate em torno da ciência, necessidade cada vez maior no contemporâneo.
Outcomes After Fecal Microbiota Transplantation in Combination With Bezlotoxumab for Inflammatory Bowel Disease and Recurrent Clostridioides difficile Infection
Authors: Allegretti Jessica R. , Axelrad Jordan , Dalal Rahul S. , Kelly Colleen R. , Grinspan Ari , Fischer Monika 
Published: March 2024

ABSTRACT
Fecal microbiota transplantation (FMT) prevents recurrent Clostridioides difficile infections (rCDI) in patients with inflammatory bowel disease. Bezlotoxumab is also indicated to prevent rCDI. We assess the impact of FMT in combination with bezlotoxumab in patients with inflammatory bowel disease and rCDI. We conducted a multicenter randomized placebo-controlled trial. All received a single colonoscopic FMT. Patients were randomized 1:1 to receive bezlotoxumab or placebo. Sixty-one patients were enrolled (30 received treatment and 31 received placebo). Overall, 5 participants (8%) experienced a CDI recurrence; 4 in the treatment arm, 1 in the placebo arm (13% vs 3%, P = 0.15). There was no clear benefit to the combination approach compared with FMT alone.
Application of SDN-IP hybrid network multicast architecture in Commercial Aerospace Data Center
Authors: Gang Chen , Guangyu Chen , Xin Tong , Qiaoyan Ren , Dongmei Kuang 
Published: March 2024

Abstract
The increasing amount of massive data generated by commercial spacecraft in orbit puts forward higher and higher requirements for the stability, reliability, and computing power of computer systems for commercial aerospace data center. Data center computer systems are gradually transforming from X86 architecture and IP network model to a platform model with cloud computing and software-defined network (SDN) technology. This article proposes a new network architecture based on a unicast/multicast protocol for data interaction between the SDN and IP network. There are three main contributions of this article. The first is that the architecture proposed in this article aims to reduce end-to-end transmission latency and packet loss. The second is to improve the flexibility of system configuration and precise control when the SND controller state changes. The third is to verify the feasibility of deploying network architecture in a real data center environment.
Evaluation of the impact of two citrus plants on the variation of Panonychus citri (Acari: Tetranychidae) and beneficial phytoseiid mites
Authors: Assouguem Amine , Joutei Abdelmalek Boutaleb , Lahlali Rachid , Kara Mohammed , Bari Ahmed , Ali Essam A. , Fidan Hafize , Laabidine Hajar Zine , El Ouati Younouss , Farah Abdellah , Lazraq Abderrahim 
Published: March 2024

Abstract
The abundance of Panonychus citri McGregor 1916 (Acari: Tetranychidae) and its associated enemies (Euseius stipulatus Athias-Henriot, 1960; Typhlodromus sp.; Phytoseiulus persimilis Athias-Henriot, 1957) was studied on two 12-year-old citrus cultivars, specifically Clementine “Nules” (Citrus Clementina) and Valencia (Citrus sinensis), in the Gharb region of Morocco. Throughout the entire monitoring period in the Valencia late cultivar, the density of the spider mite P. citri on leaves was notably higher at 38.0% (n = 1,212 mobile forms). Predator P. persimilis exhibited a leaf occupancy of 25.0% (n = 812), followed by Typhlodromus sp. at 20.0% (n = 643). Conversely, the abundance of E. stipulatus was lower at 17.0% (n = 538). In the Nules variety, P. citri abundance recorded a higher percentage at 48.0% (n = 1,922). E. stipulatus emerged as the most abundant predator at 23.0% (n = 898), followed by P. persimilis with 16.0% (n = 639). Meanwhile, the population of Typlodromus sp. remained notably low at 13.0% (n = 498). Regarding the fluctuation of the different mites studied on the two cultivars across monitoring dates, the period from May 4 to June 1 was characterized by low temperatures and a diminished presence of mite populations (P. citri, E. stipulatus, Typhlodromus sp., and P. persimilis). However, from June 7 to June 19, characterized by high temperatures, a notable increase in the presence of mite populations was observed. As regards the effect of the variety on the different mites studied, the varietal impact was significant.
Transfer of collostructions: the case of causative constructions
Authors: Gilquin Gaëtanelle 
Published: March 2024

Abstract
In an attempt to identify possible cases of collostructional transfer in the use of the causative construction [X
make
Y Vinf] by French-speaking learners of English, two types of analyses are combined in this study. First, a contrastive collostructional analysis compares the verbs occurring in the [Vinf] slot of the English construction and its French equivalent, [X
faire
Vinf Y]. Second, a contrastive interlanguage collostructional analysis compares the verbs used in the [Vinf] slot of [X
make
Y Vinf] by native speakers of English, French-speaking learners of English and learners of English from other mother tongue backgrounds. The aim is to identify verbs that are more distinctive of [X
faire
Vinf Y] than of [X
make
Y Vinf] and that are also more likely to be used by French-speaking learners of English than by other populations, as these verbs could be potential cases of collostructional preferences transferred by learners from French to English. The results suggest that learners might transfer verbs expressing a change of state or location and some individual verbs like discover from the French to the English causative construction. Their dispreference for copular verbs (other than be) could also be the result of transfer effects.
Radiofrequency thermal ablation of giant placental chorioangioma complicated with fetal hydrops: a case report and successful outcome
Authors: Le Vance Jack , Gurney Leo , Meher Shireen , Negrine Robert , Hodgetts Morton Victoria , Marton Tamas , Morris R. Katie 
Published: March 2024

Abstract

Objectives
Chorioangiomas are the most frequently occurring type of benign tumour of the placenta. However, large chorioangiomas greater than 4 cm are rare and can be more frequently associated with serious complications such as: polyhydramnios, hydrops fetalis, fetal anaemia, intrauterine growth restriction, preterm birth, and an increased risk of perinatal mortality. Importantly timely prenatal diagnosis with close surveillance alongside potential intrauterine intervention can prove impactful on pregnancy outcome and fetal survival.

Case presentation
We present a case of a 36-year-old female referred to our tertiary fetal medicine unit at 28 weeks’ gestation with a large chorioangioma measuring 9.4×8.8×5.5 cm and ultrasonographic evidence of severe fetal anaemia and fetal hydrops. The patient underwent an intrauterine transfusion and in utero surgical therapy with radiofrequency ablation (RFA). Immediately following the procedure, the fetus sustained a period of bradycardia, followed by asystole. Delivery was expedited via emergency caesarean section. Careful planning and rapid delivery after fetal intervention within the most appropriate surgical setting mitigated risks for the baby and resulted in a positive outcome. The baby was discharged from the neonatal unit on day 84 of life.

Conclusions
Large placental chorioangiomas are a rare occurrence, however, when associated with fetal complications present a high incidence of adverse perinatal outcomes. In utero interventions require careful planning and surgical expertise to ensure improved fetal and neonatal outcomes. To the best of our knowledge this case is the first recorded instance of a successful postnatal outcome following RFA for a large placental chorioangioma, whereby the fetus was complicated by fetal hydrops.
Simultaneous estimation of ibuprofen, caffeine, and paracetamol in commercial products using a green reverse-phase HPTLC method
Authors: Alqarni Mohammed Hamed , Shakeel Faiyaz , Alshehri Sultan , Foudah Ahmed Ibrahim , Aljarba Tariq Mohammed , Abdel Bar Fatma Mohamed , Alam Prawez 
Published: March 2024

Abstract
A fast, sensitive, and green reverse-phase “high-performance thin-layer chromatography” approach for the simultaneous estimation of ibuprofen (IBF), caffeine (CAF), and paracetamol (PCM) in marketed formulations was established and verified in this study. The binary combination of acetone and water (80:20 v/v) was used as the green eluent system. The current method’s greenness was predicted using four different approaches, namely National Environmental Method Index, Analytical Eco-Score (89), ChlorTox (1.08 g), and the Analytical GREENness (83) approaches, which demonstrated an outstanding greener profile. The present approach was linear in the range of 25–800 ng·band−1 for the simultaneous estimation of IBF, CAF, and PCM. In addition, the current method was accurate (% recoveries = 100 ± 2), precise (%CV < 2%), robust (%CV < 2), sensitive (LOD = 1.13–2.71 ng·band−1 and LOQ = 3.39–8.10 ng·band−1), and green. The amount of IBF, CAF, and PCM in commercial tablets was determined to be 99.51%, 98.25%, and 100.64%, respectively. The present method for the simultaneous determination of IBF, CAF, and PCM in marketed tablets is supported by these data. The findings of this study suggested that the current approach may be consistently applied to analyze IBF, CAF, and PCM in marketed tablets.
Hybrid work – a reconceptualisation and research agenda
Authors: Richter Alexander , Richter Shahper 
Published: March 2024

Abstract
We begin this conceptual paper, by outlining three recent developments in the context of the changing the nature of work: (1) the increasing proportion of remote work, (2) the quickly expanding use of (generative) AI applications, and (3) the growing advancements in virtual world technologies and platforms. We argue that the synthesis of these developments will vastly impact traditional work models and practices. This transformation warrants a critical rethinking of the traditional understanding of hybrid work which, so far, has predominantly focused on the spectrum of in-person and remote work. We suggest adjusting this perspective and posit grand challenges and related research questions in order to do so.
Effect of synthesis method on structural and magnetic properties of La0.7Ca0.2Ba0.1MnO3
Authors: Nastar-Córdoba Valeria , Guerrero Alejandra I. , Villaquiran-Raigoza Claudia , Ramírez Alfonso , Tirado Liliana , Gaona-Jurado Sonia 
Published: March 2024

Abstract
We study the effect of the synthesis method on the structural and magnetic properties of La0.7Ca0.2Ba0.1Mn03. The samples were synthesized by coprecipitation and solution combustion methods. X-ray diffraction and scanning electron microscopy were performed to investigate the crystallographic structure, showing that both methods produced La0.7Ca0.2Ba0.1Mn03 monophasic samples. From magnetization measurements a second-order, ferromagnetic to paramagnetic, phase transition was observed. The Curie temperature is found to be 272 K for the sample obtained by coprecipitation and 283 K for the sample obtained by solution combustion. There is a small magnetic hysteresis for both samples. The magnetocaloric parameters were obtained using a phenomenological model; the magnetic entropy change and relative cooling power factor are higher in the sample synthesized by combustion.
Filling the gap of distribution of the pale-winged dog-like bat Peropteryx pallidoptera (Chiroptera, Emballonuridae) in Brazil and Peru
Authors: Santos Tamily C.M. , Lopes Gerson P. , Novaes Roberto Leonan M. , Cláudio Vinícius C. , Valsecchi João , Hirota Andrezza S.V. , Martínez-Fonseca José G. , Marcos Marcelo H. , Kuniy Adriana A. , Clara do Nascimento Maria 
Published: March 2024

Abstract

Peropteryx pallidoptera is the newest described species of Peropteryx, know from only few localities in Ecuador, Peru, Brazil, Colombia, and Bolivia. Herein, we report new records of this species, and we show that P. pallidoptera has a wider distribution than known across the Amazon. Our records are based on field sampling and, mostly, on museum vouchers, which reinforces the importance of biological collections and the need to continually review deposited specimens.
Construction of 4 x 4 symmetric stochastic matrices with given spectra
Authors: Jung Jaewon , Kim Donggyun 
Published: March 2024

Abstract
The symmetric stochastic inverse eigenvalue problem (SSIEP) asks which lists of real numbers occur as the spectra of symmetric stochastic matrices. When the cardinality of a list is 4, Kaddoura and Mourad provided a sufficient condition for SSIEP by a mapping and convexity technique. They also conjectured that the sufficient condition is the necessary condition. This study presents the same sufficient condition for SSIEP, but we do it in terms of the list elements. In this way, we provide a different but more straightforward construction of symmetric stochastic matrices for SSIEP compared to those of Kaddoura and Mourad.
CD36-mediated podocyte lipotoxicity promotes foot process effacement
Authors: Hua Wei , Peng Lan , Chen Xue-mei , Jiang XuShun , Hu JianGuo , Jiang Xian-Hong , Xiang Xu , Wan Jiangmin , Long Yingfei , Xiong Jianqiong , Ma Xueyi , Du Xiaogang 
Published: March 2024

Abstract

Background
Lipid metabolism disorders lead to lipotoxicity. The hyperlipidemia-induced early stage of renal injury mainly manifests as podocyte damage. CD36 mediates fatty acid uptake and the subsequent accumulation of toxic lipid metabolites, resulting in podocyte lipotoxicity.

Methods
Male Sprague-Dawley rats were divided into two groups: the normal control group and the high-fat diet group (HFD). Podocytes were cultured and treated with palmitic acid (PA) and sulfo-N-succinimidyl oleate (SSO). Protein expression was measured by immunofluorescence and western blot analysis. Boron-dipyrromethene staining and Oil Red O staining was used to analyze fatty acid accumulation.

Results
Podocyte foot process (FP) effacement and marked proteinuria occurred in the HFD group. CD36 protein expression was upregulated in the HFD group and in PA-treated podocytes. PA-treated podocytes showed increased fatty acid accumulation, reactive oxygen species (ROS) production, and actin cytoskeleton rearrangement. However, pretreatment with the CD36 inhibitor SSO decreased lipid accumulation and ROS production and alleviated actin cytoskeleton rearrangement in podocytes. The antioxidant N-acetylcysteine suppressed PA-induced podocyte FP effacement and ROS generation.

Conclusions
CD36 participated in fatty acid-induced FP effacement in podocytes via oxidative stress, and CD36 inhibitors may be helpful for early treatment of kidney injury.