bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONSTRUCTION, DEMOLITION, EXTIRPATION? THE PALAST DER REPUBLIK AND THE CONFLICTING DESIRES OF GERMAN UNIFICATION
Authors: Hodgin Nick 
Published: April 2024

ABSTRACTOpened in 1976, East Berlin's Palast der Republik stood until its demolition in 2003 among and against the other buildings on Berlin's Museumsinsel. This article examines the circumstances surrounding the construction and demolition of the GDR's prestige construction and its storied location, now the site of the Stadtschloss and Humboldt Forum. This narrative analysis acknowledges recent vigorous debates concerning Germany's colonial history but focuses in particular on the East German past. In examining the iconoclastic impulse and the corresponding resistance to extirpation in the period since unification, the article questions the social power of the buildings at that site, their political symbolism and what the acts of demolition and reconstruction tell us about political desires and especially about Germany's unsteady handling of history since unification. Had the Palast remained, it is suggested, its awkward presence (whether as renovated structure or as ruin) might have better served the future as a reminder of uncomfortable pasts, a historical monument and a catalyst for ongoing, necessarily difficult discussions about history and heritage rather than an attempt to side‐step East German history.
The efficacy of premixed bioceramic sealers versus standard sealers on root canal treatment outcome, extrusion rate and post‐obturation pain: A systematic review and meta‐analysis
Authors: Zamparini Fausto , Lenzi Jacopo , Duncan Henry Fergus , Spinelli Andrea , Gandolfi Maria Giovanna , Prati Carlo 
Published: April 2024

AbstractBackgroundLimited evidence is available regarding the superior clinical properties of bioceramic sealers comparted with traditional standard sealers.ObjectivesThis review aimed to answer the following research questions: ‘In healthy patients requiring a root canal treatment (P), what is the efficacy of premixed bioceramic sealers (I) compared with traditional root canal epoxy resin‐based sealers (C) in terms of survival, success rates (PICO1) sealer extrusion and resorption (PICO2) post‐obturation pain (PICO3) (O)?’MethodsAuthors independently searched three electronic databases: PubMed (including MEDLINE), Web of Science, Embase and Scopus up to 31 October 2023. This was accompanied by both grey literature and manual search. Detailed selection criteria were applied, namely mature permanent teeth requiring root canal treatment, premixed bioceramic sealer with gutta‐percha as an intervention group, a standard filling technique as control group and full‐text available in English. A random‐effect meta‐analysis was used to synthesize the body of evidence regarding the use of bioceramic sealers in root canal treatment and their impact on post‐obturation pain. Effect sizes were represented as relative risks on a logarithmic scale for binary outcomes and as mean differences for continuous outcomes.ResultsA total of 941 articles were identified. Fifteen Comparative clinical studies were finally included. Eleven were randomized clinical trials, and four were prospective clinical trials with control group. The follow‐up of these studies was not greater than 2 years. No publication bias was observed in any study. No significant differences were observed between the two groups in terms of survival and success rates. A small non‐significant lower risk of extrusion was observed for bioceramics. A small, non‐significantly lower post‐operative‐pain within 24‐h was observed when bioceramics were used.DiscussionThe majority of current evidence shows inconsistencies in reporting and is of short‐term duration. Robust prospective long‐term trials are needed in this area to better support future recommendations.ConclusionThis systematic review is the first to analyse several clinical outcomes using premixed sealers. Included studies differed in terms of clinical protocol and operator expertise, but reported a similar outcome when comparing bioceramic versus standard sealers. Tooth survival, treatment outcome, post‐operative pain and periapical extrusion were similar and presented no significant differences between the two sealer types.RegistrationPROSPERO database (CRD42023449151).
Implications of husking process on the nutritional composition of sorghum grains: diverse varieties and regions
Authors: Khalfalla Maha , Zsombik László , Diósi Gerda , Győri Zoltán 
Published: April 2024

SummarySorghum, known for its nutritional value, health benefits and gluten‐free status, is now widely produced and suitable for human consumption in developed regions due to advancements in sorghum research and processing techniques. The research looked at how well the husking fraction time unit (HFTU) technique worked by examining its effects on the nutritional value of three varieties of sorghum grain. The efficiency of the husking process was assessed at 87% for concentrated and redistributed nutritional contents and 60% for variation of mineral contents based on bran/ endosperm. The technique reduced the T.K.W. compared to whole grain to the endosperm (grits). Moreover, the redistribution of the crude protein % showed the precision of the HFTU procedure by demonstrating an average of 26.6% as a variation ratio of the bran/endosperm in the data set. Contrary to the content of the total dietary fibre content, for example, the variation of TDF % attributed to bran/endosperm was 10.9%. On the other hand, the average ash % of whole grains (hummer) and husked products (TM05C) was increased by 33.2% based on averages of 1.5% and 2.1%, respectively. Accordingly, it was approved that the HFTU procedure effectively separated the endosperm (grits) and bran. This study also found that minerals such as Ca, Cu, Fe, K, Mg, Mn, Na, P, S and Zn changed over 30‐to‐80‐time units by 29%, 13%, 8%, 4%, 17%, 18%, 1%, 13%, 6% and 12% in the bran and endosperm. The HFTU process has influenced the colour attributes of variation sorghum varieties, particularly within a time scale of 80 (S) units. The research revealed that the husking technique substantially impacted the different sorghum grain varieties’ nutritional composition and colour properties. The method can be useful for developers in enhancing sorghum grain products’ nutritional properties attributed to various varieties and regions, allowing them to provide high nutritional quality sourced from sustainable products.
Effectiveness of adjuvant chemotherapy for patients who undergo radical cystectomy without neoadjuvant chemotherapy: A retrospective cohort study of 115 advanced bladder cancer patients with pathological lymph node classification
Authors: Sakura Yuma , Yamashita Ryo , Notsu Akifumi , Usui Kimitsugu , Shinsaka Hideo , Nakamura Masafumi , Matsuzaki Masato , Niwakawa Masashi 
Published: April 2024

ObjectivesWe investigated the clinical outcomes of radical cystectomy without cisplatin‐based neoadjuvant chemotherapy (NAC) and identified factors affecting the effectiveness of cisplatin‐based adjuvant chemotherapy (AC).MethodsBetween September 2002 and February 2020, 288 bladder cancer patients who did not receive NAC underwent radical cystectomy. We retrospectively analyzed the recurrence rates, primary recurrence sites, recurrence‐free survival (RFS), and overall survival (OS) of 115 advanced bladder cancer patients (pT3–4 or pN1–3) who were divided into the AC and observation groups. Subgroup analysis was performed, focusing on pathological stage.ResultsIn total, 51 patients received AC, and 64 patients were observed. The median follow‐up duration was 95 months. The recurrence rate was lower in the AC group than in the observation group (35.3% vs. 54.7%, p = 0.041). The rate of recurrences in the lymph node area (dissection site and proximal lymph nodes) was lower in the AC group (9.8% vs. 26.6%; p = 0.031). In the subgroup analysis of patients with pN1, the probability of RFS and OS was higher in the AC group than in the observation group. The hazard ratio for RFS and OS was 0.243 (95% confidence interval [CI]: 0.077–0.768) and 0.259 (95% CI: 0.082–0.816), respectively. The 5‐year RFS and OS were significantly higher in the AC group (80.0% and 79.4%) than in the observation group (35.7% and 42.9%; p < 0.008 and p < 0.012, respectively).ConclusionsAC improved RFS and OS in patients with pN1 disease who did not receive NAC and should be considered for this population.
Wound healing rates in COPD patients undergoing traditional pulmonary rehabilitation versus tailored Wound‐Centric interventions
Authors: He Yan , Zhu He , Xu Wenjie , Wang Tao , Chen Ying 
Published: April 2024

AbstractThis comparative cross‐sectional study, conducted at Shanghai Pulmonary Hospital, aimed to evaluate the efficacy of tailored wound‐centric interventions (TWCI) versus traditional pulmonary rehabilitation (TPR) in enhancing wound healing in patients with chronic obstructive pulmonary disease (COPD). Enrolling 340 patients with confirmed COPD, the study randomly assigned participants to either the TWCI or TPR group for a 12‐week programme. The primary outcome measured was the rate of wound healing, with secondary outcomes including changes in pulmonary function tests (PFTs) and quality of life (QoL) scores. The TWCI group received a customized programme integrating standard pulmonary rehabilitation with specific wound care strategies, such as enhanced oxygen therapy, nutritional supplementation, and infection control measures. In contrast, the TPR group underwent a conventional pulmonary rehabilitation programme without targeted wound care interventions. Wound healing rates, PFTs, and QoL scores were assessed at the end of the intervention and 3 months post‐intervention. The TWCI group demonstrated a statistically significant improvement in wound healing rates compared with the TPR group. The TWCI group had a 15% higher rate of reduction in wound size, a 10% rise in complete healing rates, and a 20% drop in infection rates (p < 0.05). Specifically, TWCI group exhibited higher rates of wound size reduction, complete healing, and decreased infection rates. Additionally, long‐term pulmonary function and overall quality of life improvements were more pronounced in the tailored group, underscoring the benefits of a personalized approach to managing COPD and wound care. The study concluded that integrating wound‐specific care strategies with pulmonary rehabilitation significantly enhances health outcomes in COPD patients with wounds. These findings supported the adoption of customized, multidisciplinary care plans, suggesting that tailored interventions can offer a comprehensive solution to the complex needs of COPD patients, potentially redefining best practices in chronic disease management.
Surgical versus medical management of patients with primary hyperaldosteronism and indeterminate adrenal vein sampling: A 10‐year experience of the Cleveland Clinic
Authors: Onwubueke Chineme , Borgan Saif M , Xiao Huijun , Zhou Keren 
Published: April 2024

AbstractIn patients with primary hyperaldosteronism (PA), adrenal vein sampling (AVS) can identify patients suitable for unilateral adrenalectomy. However, in AVS with an indeterminate aldosterone‐to‐cortisol lateralization (ACL) ratio of 3.0–4.0, clinical guidance is unclear. The authors screened all patients undergoing AVS at the Cleveland Clinic from October 2010 to January 2021 and identified 18 patients with indeterminate ACL results. Ten underwent adrenalectomy and eight continued medical management. The surgical group was younger (58.5 vs. 68 years, p = .17), and more likely to have a unilateral imaging adrenal abnormality (90% vs. 38%, p = .043) and a lower contralateral suppression index (0.63 vs. 1.1, p = .14). Post‐treatment, the surgical group had a significant reduction in diastolic blood pressure (–5.5 mmHg, p = .043) and aldosterone (4.40 vs. 35.80 ng/mL, p = .035) and required fewer anti‐hypertensive medications (2 vs. 3, p = .015). These findings may support the benefit of adrenalectomy in a select group of patients with indeterminate ACL.
Sequential sampling plan for the adults of Conotrachelus psidii (Marshall, 1922) (Coleoptera: Curculionidae) in guava crop
Authors: Fernandes Marcos Gino , Costa Eduardo Neves , Valente Fabrício Iglesias 
Published: April 2024

AbstractUnderstanding the spatial distribution and population fluctuations of insect pests facilitates the development of effective control strategies for a given crop. Conotrachelus psidii (Coleoptera: Curculionidae) is an important guava pest; however, no sampling plans are available for its management. Therefore, in this study, we aimed to (i) determine the spatial distribution pattern of C. psidii adults and (ii) develop a sequential sampling plan for pest control in guava crops. Evaluations began at 120 days after pruning and were performed weekly. To sample C. psidii adults, a white tarp was placed under the plants, covering the entire canopy. Plant branches were then shaken to dislodge the adult insects on the tarp, which were then identified and counted. Using the data obtained in each sampling, dispersion indices were determined and tests of adjustments to the theoretical Poisson and negative binomial frequency distributions were performed. The calculated dispersion indices revealed that the individuals in the studied populations exhibited aggregated dispersion. Notably, only four samples showed adjustment to the Poisson distribution, whereas 18 samples showed adjustment to the negative binomial distribution in the field, confirming the aggregated pattern of the population spatial arrangement. The sequential sampling plan developed for C. psidii revealed the maximum and minimum numbers of sample units expected for decision‐making as 45 and 15, respectively.
The asset growth return premium and anchoring on the 52‐week high
Authors: Blau Benjamin M. , Cannon Brad 
Published: April 2024

AbstractResearch shows that year‐over‐year growth in a firm's assets is associated with a negative stock return premium. A possible explanation for this premium is based on mispricing correction, due in part to investors' overvaluation related to investment. In this article, we argue that a correction of any type is more likely to occur when stock prices are further away from their 52‐week high. To the extent that the 52‐week high acts as a viable anchor, when stocks are closer to this anchor, investors might become less inclined to contribute to the typical downward correction for these types of growth firms. In several tests, we find that stocks that are furthest away exhibit the strongest return premium. The return premium, however, begins to disappear as stocks approach their 52‐week high. These results are robust to various risk factors and cross‐sectional tests that include several firm‐specific characteristics.
Zombie Credit and (Dis‐)Inflation: Evidence from Europe
Authors: ACHARYA VIRAL V. , CROSIGNANI MATTEO , EISERT TIM , EUFINGER CHRISTIAN 
Published: April 2024

ABSTRACTWe show that “zombie credit”—subsidized credit to nonviable firms—has a disinflationary effect. By keeping these firms afloat, zombie credit creates excess aggregate supply, thereby putting downward pressure on prices. Granular European data on inflation, firms, and banks confirm this mechanism. Markets affected by a rise in zombie credit experience lower firm entry and exit, capacity utilization, markups, and inflation, as well as a misallocation of capital and labor, which results in lower productivity, investment, and value added. If weakly capitalized banks were recapitalized in 2009, inflation in Europe would have been up to 0.21 percentage points higher post‐2012.
The psychological and behavioral consequences of customer empowerment in new product development: Situational framework, review, and research agenda
Authors: Maier Lukas , Baccarella Christian V. 
Published: April 2024

AbstractIn search of innovation and market success, firms have started to empower their customers in many ways, from customizing and self‐producing their own products (products made for one) to selecting and designing products for the broader marketplace (products made for many). This power shift has important behavioral and psychological consequences for customers and, hence, has attracted considerable interest from academics and practitioners alike. However, the literature is scattered, provides inconsistent findings, and lacks both a comprehensive conceptualization and empirical overview. Specifically, extant literature neglects the situational nature of customer empowerment, equalizing inherently different customer empowerment activities while failing to consider the divergent effects on participating versus observing customers (i.e., customers who do not participate in the new product development process themselves). This limits advancement of the field, and impedes integration with the related fields of innovation, marketing, and consumer research. To facilitate a better understanding of the psychological and behavioral consequences of customer empowerment, we systematically review literature in the field and develop a conceptual framework that integrates different customer empowerment situations and their respective psychological (e.g., firm perceptions and feelings of empowerment) and behavioral (e.g., product preferences and willingness‐to‐pay) consequences. Using this framework, we structure previous research, highlight similarities and differences across customer empowerment situations, and set the stage for future research. By taking a customer perspective, this research advances our understanding of why some customer empowerment strategies are more successful than others (and under which circumstances). On a broader level, we show that adopting a behavioral and psychological perspective may be a promising way to study innovation.
The complex, confusing and poorly understood immune responses to AAV‐mediated gene transfer in haemophilia—Is more or less immunosuppression required?
Authors: Tuddenham Edward G. D. , Foster Graham R. 
Published: April 2024

AbstractAttempts to achieve a functional cure or amelioration of the severe X linked bleeding disorders haemophilia A (factor VIII deficiency) and haemophilia B (factor IX deficiency) using AAV‐based vectors have been frustrated by immune responses that limit efficacy and durability. The immune responses include adaptive and innate pathways as well as cytokine mediated inflammation, especially of the target organ cells—hepatocytes. Immune suppression has only been partly effective in clinical trials at ameliorating the immune response and the lack of good animal models has delayed progress in identifying mechanisms and developing more effective approaches to controlling these effects of AAV gene transfer. Here we discuss the arguments for and against more potent immunosuppression to improve factor expression after AAV‐mediated gene therapy.
Global prevalence of onychomycosis in general and special populations: An updated perspective
Authors: Gupta Aditya K. , Wang Tong , Polla Ravi Shruthi , Mann Avantika , Bamimore Mary A. 
Published: April 2024

AbstractBackgroundOnychomycosis is a chronic nail disorder commonly seen by healthcare providers; toenail involvement in particular presents a treatment challenge.ObjectiveTo provide an updated estimate on the prevalence of toenail onychomycosis.MethodsWe conducted a literature search using PubMed, Embase and Web of Science. Studies reporting mycology‐confirmed diagnoses were included and stratified into (a) populations‐based studies, and studies that included (b) clinically un‐suspected and (c) clinically suspected patients.ResultsA total of 108 studies were included. Based on studies that examined clinically un‐suspected patients (i.e., with or without clinical features suggestive of onychomycosis), the pooled prevalence rate of toenail onychomycosis caused by dermatophytes was 4% (95% CI: 3–5) among the general population; special populations with a heightened risk include knee osteoarthritis patients (RR: 14.6 [95% CI: 13.0–16.5]), chronic venous disease patients (RR: 5.6 [95% CI: 3.7–8.1]), renal transplant patients (RR: 4.7 [95% CI: 3.3–6.5]), geriatric patients (RR: 4.7 [95% CI: 4.4–4.9]), HIV‐positive patients (RR: 3.7 [95% CI: 2.9–4.7]), lupus erythematosus patients (RR: 3.1 [95% CI: 1.2–6.3]), diabetic patients (RR: 2.8 [95% CI: 2.4–3.3]) and hemodialysis patients (RR: 2.8 [95% CI: 1.9–4.0]). The prevalence of onychomycosis in clinically suspected patients was significantly higher likely due to sampling bias. A high degree of variability was found in a limited number of population‐based studies indicating that certain pockets of the population may be more predisposed to onychomycosis. The diagnosis of non‐dermatophyte mould onychomycosis requires repeat sampling to rule out contaminants or commensal organisms; a significant difference was found between studies that performed single sampling versus repeat sampling. The advent of PCR diagnosis results in improved detection rates for dermatophytes compared to culture.ConclusionOnychomycosis is an underrecognized healthcare burden. Further population‐based studies using standardized PCR methods are warranted.
Preoperative antibiotics are not indicated prior to closure of oroantral communication
Authors: Woo V. M. , Delpachitra S. N. 
Published: April 2024

AbstractObjectiveThe aim of this paper was to determine whether the use of preoperative antibiotics improves surgical outcomes following oroantral communication (OAC) closure.Materials and MethodsA single‐centre, retrospective study was conducted on all OAC repair procedures over a 24‐month period assessing a number of datapoints including the site of OAC occurrence, time to repair, local anaesthetic or general anaesthetic, and any complications noted. Patient follow‐up was up to 3 months post‐operative OAC closure. Data outputs primarily included descriptive statistics for demographic datasets included in the study. Fisher's exact test was used to determine non‐random associations between categorical variables (preoperative antibiotics vs. no preoperative antibiotics; successful closure vs. failed closure).ResultsThirty‐one patients met the inclusion criteria and timeframe of this study. All OACs were a result of dental extraction. For patients who had an OAC visualised immediately after extraction, 18 had an OAC repair completed on the same day. Fifteen patients had a delayed closure, defined as a closure over 48 h following the development of OAC. Thirteen patients had their procedure completed under local anaesthetic; none had preoperative antibiotics prior to surgery. Only one patient with delayed closure of an OAC who had a procedure completed under local anaesthetic had a prophylactic dose 1 h prior to surgery. Patients who underwent OAC closure under general anaesthetic received an intra‐operative dose of antibiotics. Using Fisher's exact test, there was no significant difference between the two groups (preoperative antibiotics given vs. no preoperative antibiotics given) with regard to the likelihood of success following OAC closure (p = 0.1419).ConclusionThis study demonstrates that the routine use of preoperative antibiotics may not improve surgical outcomes following the closure of oroantral communication.