bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human biodistribution and radiation dosimetry for the tau tracer [18F]Florzolotau in healthy subjects
Authors: Lin Kun-Ju , Huang Shao-Yi , Huang Kuo-Lun , Huang Chin-Chang , Hsiao Ing-Tsung 
Published: April 2024

Abstract
Background
Tau pathology plays a crucial role in neurodegeneration diseases including Alzheimer’s disease (AD) and non-AD diseases such as progressive supranuclear palsy. Tau positron emission tomography (PET) is an in-vivo and non-invasive medical imaging technique for detecting and visualizing tau deposition within a human brain. In this work, we aim to investigate the biodistribution of the dosimetry in the whole body and various organs for the [18F]Florzolotau tau-PET tracer. A total of 12 healthy controls (HCs) were enrolled at Chang Gung Memorial Hospital. All subjects were injected with approximately 379.03 ± 7.03 MBq of [18F]Florzolotau intravenously, and a whole-body PET/CT scan was performed for each subject. For image processing, the VOI for each organ was delineated manually by using the PMOD 3.7 software. Then, the time-activity curve of each organ was acquired by optimally fitting an exponential uptake and clearance model using the least squares method implemented in OLINDA/EXM 2.1 software. The absorbed dose for each target organ and the effective dose were finally calculated.

Results
From the biodistribution results, the elimination of [18F]Florzolotau is observed mainly from the liver to the intestine and partially through the kidneys. The highest organ-absorbed dose occurred in the right colon wall (255.83 μSv/MBq), and then in the small intestine (218.67 μSv/MBq), gallbladder wall (151.42 μSv/MBq), left colon wall (93.31 μSv/MBq), and liver (84.15 μSv/MBq). Based on the ICRP103, the final computed effective dose was 34.9 μSv/MBq with CV of 10.07%.

Conclusions
The biodistribution study of [18F]Florzolotau demonstrated that the excretion of [18F]Florzolotau are mainly through the hepatobiliary and gastrointestinal pathways. Therefore, a routine injection of 370 MBq or 185 MBq of [18F]Florzolotau leads to an estimated effective dose of 12.92 or 6.46 mSv, and as a result, the radiation exposure to the whole-body and each organ remains within acceptable limits and adheres to established constraints.

Trial registration

Retrospectively Registered at Clinicaltrials.gov (NCT03625128) on 12 July, 2018, https://clinicaltrials.gov/study/NCT03625128.
DTA: distribution transform-based attack for query-limited scenario
Authors: Liu Renyang , Zhou Wei , Jin Xin , Gao Song , Wang Yuanyu , Wang Ruxin 
Published: April 2024

AbstractIn generating adversarial examples, the conventional black-box attack methods rely on sufficient feedback from the to-be-attacked models by repeatedly querying until the attack is successful, which usually results in thousands of trials during an attack. This may be unacceptable in real applications since Machine Learning as a Service Platform (MLaaS) usually only returns the final result (i.e., hard-label) to the client and a system equipped with certain defense mechanisms could easily detect malicious queries. By contrast, a feasible way is a hard-label attack that simulates an attacked action being permitted to conduct a limited number of queries. To implement this idea, in this paper, we bypass the dependency on the to-be-attacked model and benefit from the characteristics of the distributions of adversarial examples to reformulate the attack problem in a distribution transform manner and propose a distribution transform-based attack (DTA). DTA builds a statistical mapping from the benign example to its adversarial counterparts by tackling the conditional likelihood under the hard-label black-box settings. In this way, it is no longer necessary to query the target model frequently. A well-trained DTA model can directly and efficiently generate a batch of adversarial examples for a certain input, which can be used to attack un-seen models based on the assumed transferability. Furthermore, we surprisingly find that the well-trained DTA model is not sensitive to the semantic spaces of the training dataset, meaning that the model yields acceptable attack performance on other datasets. Extensive experiments validate the effectiveness of the proposed idea and the superiority of DTA over the state-of-the-art.
Falciparum malaria case acquired by wound exposed to the blood of infected malaria patient
Authors: Ibrahim Hamdy , Maksod Safwat Abdel , Khorshed Magdy , Rady Hanan , Mohamed Aadel , Alkassas Omar , Haron Marwa , Saeed Suzan , Mahmod Mohamed , Ismail Khaled 
Published: April 2024

AbstractMalaria is a serious Anopheles mosquito-borne disease. It is not endemic in Egypt but continues to be imported by travelers returning from endemic areas. The transmission of malaria in non-endemic areas is an extremely unusual event, but it is possible under certain conditions.Herein, we report a case of prolonged fever in a patient living in the countryside of Egypt with no reported travel history following accidental blood exposure to a malaria patient. The purpose is to shed light on this rare mode of malaria transmission and also to alert physicians and infectious disease specialists to consider malaria in the differential diagnosis in case of contact history to the blood of a malaria patient.
Long non-coding RNA (H19) in patients with spondyloarthritis: association with disease parameters and ultrasonographic findings
Authors: EL-Zwawy A. I. , Soliman Eiman , Elsayed Eman T. , Morsy Mai M. 
Published: April 2024

Abstract
Background
Spondyloarthritis is a well-known chronic inflammatory disorder; despite recent advances, its genetic basis remains poorly understood. Recently, long non-coding RNA (H19) was identified to be associated with various human cancers and studied in some autoimmune diseases. Musculoskeletal ultrasound has been shown to have good sensitivity and specificity in detecting enthesitis. The Belgrade Ultrasound Enthesitis Score (BUSES) has recently been proposed as a comprehensive ultrasound enthesitis scoring system for differentiating between individuals with enthesitis associated with spondyloarthritis and those without spondyloarthritis.

Aim
The current work aimed to study the role of long non-coding RNA (H19) as a potential biomarker in axial spondyloarthritis and its relationship with the different disease parameters (clinical and laboratory), disease activity, and functional status as well as the relation between long non-coding RNA (H19) and articular manifestations using ultrasonographic assessment of enthesitis.

Results
Long non-coding RNA (H19) expression was statistically higher in axial spondyloarthritis patients than controls; there are no statistically significant correlations between long non-coding RNA (H19) relative expression and any of the listed parameters (ESR, CRP, ASDAS-CRP, BASDAI, BASFI, BASMI, BUSES, SPARCC index, mSASSS). As regards the Spearman correlation of Belgrade Ultrasound Enthesitis Score, it showed a statistically significant positive correlation with ASDAS-CRP, BASDAI, and BASMI (p value: 0.002, 0.02, and 0.046, respectively).

Conclusion
Both long non-coding RNA (H19) and Belgrade Ultrasound Enthesitis Score have good discriminative ability between patients with axial spondyloarthritis and normal population; this suggests a possible role in early diagnosis for patients with axial spondyloarthritis who do not fulfill ASAS classification criteria. Their role to monitor the disease activity still needs further studies to be established. Musculoskeletal ultrasound is much more accurate in the assessment of enthesis than clinical examination. Further studies are needed to study the correlation between ultrasonographic entheseal scores and activity markers either clinically or laboratory.
The treating psychiatrist as expert witness
Authors: Broughton Trevor , Thomas Toral 
Published: April 2024

SUMMARYMany authors have considered the ethical dilemmas of a doctor being both the treating physician and expert witness in litigation. The debate has often focused on the potential for bias and the adverse impact being an expert witness can have on the therapeutic alliance. Much of this debate seems rooted in the ethic of non-maleficence. In this article we attempt to examine the other end of this ethical quandary. Using a pragmatic approach, we explore these conflicts and consider biases from other sources. Ultimately, taking on the mantle of both roles is becoming increasingly unavoidable. Hence we argue that, although there are challenges, embracing this dual role can be an important part of holistic treatment, risk management and the pursuit of the ethical principle of justice.
Conceptual competence in psychiatric training: building a culture of conceptual inquiry
Authors: Aftab Awais , Sadler John Z. , Kious Brent M. , Waterman G. Scott 
Published: April 2024

Summary
Building a culture of conceptual inquiry in psychiatric training requires the development of conceptual competence: the ability to identify and examine assumptions that constitute the philosophical foundations of clinical care and scientific investigation in psychiatry. In this article, we argue for the importance of such competence and illustrate approaches to instilling it through examples drawn from our collective experiences as psychiatric educators.
Development and Evaluation of a Multisource Approach to Extend Mortality Follow-Up for Older Adults With Advanced Cancer Enrolled in Randomized Trials
Authors: Lund Jennifer L. , Cacciatore Jenna , Tylock Rachael , Su I-Hsuan , Sharma Saloni , Hinton Sharon Peacock , Smith Sabirah , Nowels Molly A. , Chen Xiaomeng , Duberstein Paul R. , Hanson Laura C. , Mohile Supriya G. 
Published: April 2024

PURPOSE Mortality data can complement primary end points from cancer clinical trials. Yet, identifying deaths after trial completion is challenging, as timely and comprehensive vital status data are unavailable in the United States. We developed and evaluated a multisource approach to capture death data after clinical trial completion. METHODS Individuals age 70 years and older with incurable solid tumors or lymphoma and ≥1 aging-related condition were enrolled from October 2014 to March 2019 (ClinicalTrials.gov identifier: NCT02107443 and NCT02054741 ). Participants provided consent to link trial information to external sources. We developed a stepped approach for extended death capture using (1) active trial follow-up up to 1 year, (2) linkage to the National Death Index (NDI), and (3) obituary searches, thus generating a 5-year survival curve. In a random sample of 50 participants who died during trial follow-up, we estimated sensitivity of death data using NDI and obituary sources and computed survival times by data source. RESULTS The two trials enrolled 1,169 participants; mean age was 76 years; 46% were female; and gastrointestinal cancer (30%) and lung cancer (26%) were the most common cancer types. Across data sources, maximum follow-up was >7 years; 5-year survival was 18%. In total, there were 841 deaths: 603 identified during trial follow-up; 199 from the NDI; and 39 from obituary searches. The sensitivity for death capture was 92% for the NDI and 94% for the obituary searches compared with the trial data, and computed survival times were similar across data sources. CONCLUSION Extending clinical trial mortality follow-up through linkage with external data sources was feasible and accurate. Future cancer clinical trials should collect necessary consent and patient identifiers for vital status linkages that can enhance understanding of longer-term outcomes.
National Estimates of the Participation of Patients With Cancer in Clinical Research Studies Based on Commission on Cancer Accreditation Data
Authors: Unger Joseph M. , Shulman Lawrence N. , Facktor Matthew A. , Nelson Heidi , Fleury Mark E. 
Published: April 2024

PURPOSE
National estimates of cancer clinical trial participation are nearly two decades old and have focused solely on enrollment to treatment trials, which does not reflect the willingness of patients to contribute to other elements of clinical research. We determined inclusive, contemporary estimates of clinical trial participation for adults with cancer using a national sample of data from the Commission on Cancer (CoC).

METHODS
The data were obtained from accreditation information submitted by the 1,200 CoC programs, which represent more than 70% of all cancer cases diagnosed in the United States each year. Deidentified, institution-level aggregate counts of annual enrollment to treatment, biorepository, diagnostic, economic, genetic, prevention, quality-of-life (QOL), and registry studies were examined. Overall, study-type estimates for the period 2013-2017 were estimated. Multiple imputation by chained equations was used to account for missing data, with summary estimates calculated separately by type of program (eg, National Cancer Institute [NCI]–designated cancer centers) and pooled.

RESULTS
The overall estimated patient participation rate to cancer treatment trials was 7.1%. Patients with cancer participated in a wide variety of other studies, including biorepository (12.9%), registry (7.3%), genetic (3.6%), QOL (2.8%), diagnostic (2.5%), and economic (2.4%) studies. Treatment trial enrollment was 21.6% at NCI-designated comprehensive cancer centers, 5.4% at academic (non–NCI-designated) comprehensive cancer programs, 5.7% at integrated network cancer programs, and 4.1% at community programs. One in five patients (21.9%) participated in one or more cancer clinical research studies.

CONCLUSION
In a first-time use of national accreditation information from the CoC, enrollment to cancer treatment trials was 7.1%, higher than historical estimates of <5%. Patients participated in a diverse set of other study types. Contributions of adult patients with cancer to clinical research is more common than previously understood.
HD-Zip II transcription factors control distal stem cell fate in Arabidopsis roots by linking auxin signaling to the FEZ/SOMBRERO pathway
Authors: Possenti Marco , Sessa Giovanna , Alfè Altea , Turchi Luana , Ruzza Valentino , Sassi Massimiliano , Morelli Giorgio , Ruberti Ida 
Published: April 2024

ABSTRACT
In multicellular organisms, specialized tissues are generated by specific populations of stem cells through cycles of asymmetric cell divisions, where one daughter undergoes differentiation and the other maintains proliferative properties. In Arabidopsis thaliana roots, the columella – a gravity-sensing tissue that protects and defines the position of the stem cell niche – represents a typical example of a tissue whose organization is exclusively determined by the balance between proliferation and differentiation. The columella derives from a single layer of stem cells through a binary cell fate switch that is precisely controlled by multiple, independent regulatory inputs. Here, we show that the HD-Zip II transcription factors (TFs) HAT3, ATHB4 and AHTB2 redundantly regulate columella stem cell fate and patterning in the Arabidopsis root. The HD-Zip II TFs promote columella stem cell proliferation by acting as effectors of the FEZ/SMB circuit and, at the same time, by interfering with auxin signaling to counteract hormone-induced differentiation. Overall, our work shows that HD-Zip II TFs connect two opposing parallel inputs to fine-tune the balance between proliferation and differentiation in columella stem cells.
Male and female syringeal muscles exhibit superfast shortening velocities in zebra finches
Authors: Gladman Nicholas W. , Elemans Coen P. H. 
Published: April 2024

ABSTRACT
Vocalisations play a key role in the communication behaviour of many vertebrates. Vocal production requires extremely precise motor control, which is executed by superfast vocal muscles that can operate at cycle frequencies over 100 Hz and up to 250 Hz. The mechanical performance of these muscles has been quantified with isometric performance and the workloop technique, but owing to methodological limitations we lack a key muscle property characterising muscle performance, the force–velocity relationship. Here, we quantified the force–velocity relationship in zebra finch superfast syringeal muscles using the isovelocity technique and tested whether the maximal shortening velocity is different between males and females. We show that syringeal muscles exhibit high maximal shortening velocities of 25L0 s−1 at 30°C. Using Q10-based extrapolation, we estimate they can reach 37–42L0 s−1 on average at body temperature, exceeding other vocal and non-avian skeletal muscles. The increased speed does not adequately compensate for reduced force, which results in low power output. This further highlights the importance of high-frequency operation in these muscles. Furthermore, we show that isometric properties positively correlate with maximal shortening velocities. Although male and female muscles differ in isometric force development rates, maximal shortening velocity is not sex dependent. We also show that cyclical methods to measure force–length properties used in laryngeal studies give the same result as conventional stepwise methodologies, suggesting either approach is appropriate. We argue that vocal behaviour may be affected by the high thermal dependence of superfast vocal muscle performance.
Effects of ingesting large prey on the kinematics of rectilinear locomotion in Boa constrictor
Authors: Petersen Jarrod C. , Jayne Bruce C. , Wilde Alexander D. , Capano John G. , Roberts Thomas J. 
Published: April 2024

ABSTRACT
Large and stout snakes commonly consume large prey and use rectilinear crawling; yet, whether body wall distention after feeding impairs rectilinear locomotion is poorly understood. After eating large prey (30–37% body mass), all Boa constrictor tested could perform rectilinear locomotion in the region with the food bolus despite a greatly increased distance between the ribs and the ventral skin that likely lengthens muscles relevant to propulsion. Unexpectedly, out of 11 kinematic variables, only two changed significantly (P&lt;0.05) after feeding: cyclic changes in snake height increased by more than 1.5 times and the longitudinal movements of the ventral skin relative to the skeleton decreased by more than 25%. Additionally, cyclic changes in snake width suggest that the ribs are active and mobile during rectilinear locomotion, particularly in fed snakes, but also in unfed snakes. These kinematic changes suggest that rectilinear actuators reorient more vertically and undergo smaller longitudinal excursions following large prey ingestion, both of which likely act to reduce elongation of these muscles that may otherwise experience substantial strain.
Stepping Sideways to Step up: Lateral Mobility and Career Advancement Inside Organizations
Authors: Bidwell Matthew , Keller J. R. 
Published: April 2024

Although internal labor market theory emphasizes promotions as the main form of mobility within organizations, many internal job moves take people sideways into jobs that are at the same hierarchical level as the one that was left. Despite the prevalence of these lateral moves, however, we have little evidence on what role they play in workers’ careers. We argue that lateral mobility can facilitate subsequent career advancement by allowing for the development and demonstration of new skills and can, therefore, help those who would struggle to be promoted from their current job to develop their careers further. We establish empirical evidence on the implications of lateral mobility using eight years of personnel data from a large U.S. healthcare company. Our analyses show that those employees who move laterally are more likely to be subsequently promoted and achieve substantially higher pay growth than a matched sample of employees. We also find that lateral moves are more likely to be undertaken by those who have spent longer in the job but have lower performance than those who are promoted. This pattern of results suggests that lateral mobility provides an important avenue for career growth as people who step sideways in organizations are more likely to subsequently step up. This paper was accepted by Lamar Pierce, organizations. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.03746 .
Investor Logins and the Disposition Effect
Authors: Quispe-Torreblanca Edika , Gathergood John , Loewenstein George , Stewart Neil 
Published: April 2024

Using data from an online brokerage, we examine the role of investor logins in trading behavior. We find that a new reference point is created when an investor logs in and views the investor’s portfolio. We observe this as a disposition effect on returns since last login in addition to the traditional disposition effect on returns since purchase. Further, these reference points produce a strong interaction such that even a small loss since last login nullifies the positive effect of a gain since purchase. This interaction follows if investors select the higher, more aspirational price as a reference point. This paper was accepted by Yuval Rottenstreich, behavioral economics and decision analysis. Funding: This work was supported by the Economic and Social Research Council [Grants ES/K002201/1, ES/N018192/1, ES/P008976/1, and ES/V004867/1] and the Leverhulme Trust [Grant RP2012-V-022]. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.00359 .
Clinical efficacy of femtosecond laser-assisted phacoemulsification in diabetic cataract patients
Authors: Tang Yi-Fei , Duan Zhi-Hui 
Published: April 2024

BACKGROUND
Diabetic patients with cataracts encounter specific difficulties during cataract surgery due to alterations in microcirculation, blood supply, metabolism, and the microenvironment. Traditional phacoemulsification may not fully tackle these issues, especially in instances with substantial preoperative astigmatism. The utilization of femtosecond laser-assisted phacoemulsification, in conjunction with Toric intraocular lens (IOL) implantation, offers a potentially more efficient strategy. This research seeks to evaluate the efficacy and possible complications of this approach in diabetic cataract patients.
AIM
To investigate the clinical efficacy and complications of femtosecond laser-assisted phacoemulsification combined with Toric IOL implantation in diabetic cataract patients, comparing it with traditional phacoemulsification methods.
METHODS
This retrospective study enrolled 120 patients with diabetes cataract from May 2019 to May 2021. The patients were divided into two groups: the control group underwent traditional phacoemulsification and Toric IOL implantation, while the treatment group received Len Sx femtosecond laser-assisted treatment. Outcome measures included naked eye vision, astigmatism, high-level ocular phase difference detection, clinical efficacy, and complication.
RESULTS
There were no significant preoperative differences in astigmatism or naked eyesight between the two groups. However, postoperative improvements were observed in both groups, with the treatment group showing greater enhancements in naked eye vision and astigmatism six months after the procedure. High-level corneal phase difference tests also indicated significant differences in favor of the treatment group.
CONCLUSION
This study suggests that femtosecond laser-assisted phacoemulsification combined with Toric IOL implantation appears to be more effective in enhancing postoperative vision in diabetic cataract patients compared to traditional methods offering valuable insights for clinical practice.