bluuebunny/crossref_metadata_2025_split huggingface dataset:
STING agonist, SMA-2, inhibits clear cell renal cell carcinoma through improving tumor microenvironment
Authors: Wang Wei , Zhang Fengqing , Hu Yan , Liu Guangming 
Published: April 2024

AbstractClear cell renal cell carcinoma (ccRCC) is the most prevalent and lethal subtype of kidney cancer, patients with ccRCC usually have very poor prognosis and short survival. Therefore, it is urgent to develop more effective therapeutics or medications to suppress ccRCC progression. Here, we demonstrated that STING agonist, MSA-2 significantly inhibits tumor progress and prolongs the survival of ccRCC mice by promoting cytokines secretion. Moreover, MSA-2 triggered the trafficking and infiltration of CD8+ T cells, supported by the generation of a chemokine milieu that promoted recruitment and modulation of the immunosuppressive TME in ccRCC. These findings suggest that MSA-2 potentially serves an effective and preferable adjuvant immunotherapy of ccRCC.
Novel opportunities for clinical pharmacy research: development of a machine learning model to identify medication related causes of delirium in different patient groups
Authors: Weidmann Anita Elaine , Watson Edward William 
Published: April 2024

AbstractThe advent of artificial intelligence (AI) technologies has taken the world of science by storm in 2023. The opportunities of this easy to access technology for clinical pharmacy research are yet to be fully understood. The development of a custom-made large language model (LLM) (DELSTAR) trained on a wide range of internationally recognised scientific publication databases, pharmacovigilance sites and international product characteristics to help identify and summarise medication related information on delirium, as a proof-of-concept model, identified new facilitators and barriers for robust clinical pharmacy practice research. This technology holds great promise for the development of much more comprehensive prescribing guidelines, practice support applications for clinical pharmacy, increased patient and prescribing safety and resultant implications for healthcare costs. The challenge will be to ensure its methodologically robust use and the detailed and transparent verification of its information accuracy.
How artificial intelligence will transform project management in the age of digitization: a systematic literature review
Authors: Nenni Maria Elena , De Felice Fabio , De Luca Cristina , Forcina Antonio 
Published: April 2024

AbstractAmong the causes of the low success rate of the projects (around 35% of the total) is the low level of maturity of the technologies available for the management of the projects themselves. However, today many researchers, startups and innovative companies are starting to apply artificial intelligence (AI), machine learning and other advanced technologies to the field of project management. By 2030 the industry will undergo significant changes. By using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) protocol this paper explores the intersection of project risk management and AI. The study highlights how AI-driven methodologies and tools can revolutionize the way project risks are managed throughout the project lifecycle. Specifically, 215 papers have been analysed to explore how the scientific community has been moving so far on the topic. Besides, a cross-sectional investigation of the PM processes and AI categories/tools was carried out to identify any path that is prevalent, where the prevalence comes from, and for which PM process or sector it is most successful. Finally, from this study several gaps emerged that scientific research would have to fill to effectively implement AI in PM and that have been turned into opportunities for future research in the form of a research agenda.
Polytomous Effectiveness Indicators in Complex Problem-Solving Tasks and Their Applications in Developing Measurement Model
Authors: Wang Pujue , Liu Hongyun 
Published: April 2024

Recent years have witnessed the emergence of measurement models for analyzing action sequences in computer-based problem-solving interactive tasks. The cutting-edge psychometrics process models require pre-specification of the effectiveness of state transitions often simplifying them into dichotomous indicators. However, the dichotomous effectiveness becomes impractical when dealing with complex tasks that involve multiple optimal paths and numerous state transitions. Building on the concept of problem-solving, we introduce polytomous indicators to assess the effectiveness of problem states ds\documentclass[12pt]{minimal}
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\begin{document}$${\mathrm {\Delta }d}_{\mathrm {s\rightarrow s'}}$$\end{document}. The three-step evaluation method for these two types of indicators is proposed and illustrated across two real problem-solving tasks. We further present a novel psychometrics process model, the sequential response model with polytomous effectiveness indicators (SRM-PEI), which is tailored to encompass a broader range of problem-solving tasks. Monte Carlo simulations indicated that SRM-PEI performed well in the estimation of latent ability and transition tendency parameters across different conditions. Empirical studies conducted on two real tasks supported the better fit of SRM-PEI over previous models such as SRM and SRMM, providing rational and interpretable estimates of latent abilities and transition tendencies through effectiveness indicators. The paper concludes by outlining potential avenues for the further application and enhancement of polytomous effectiveness indicators and SRM-PEI.
Spousal bereavement and its effects on later life physical and cognitive capability: the Tromsø study
Authors: Strand Bjørn Heine , Håberg Asta K. , Eyjólfsdóttir Harpa Sif , Kok Almar , Skirbekk Vegard , Huxhold Oliver , Løset Gøril Kvamme , Lennartsson Carin , Schirmer Henrik , Herlofson Katharina , Veenstra Marijke 
Published: April 2024

AbstractSpousal bereavement is associated with health declines and increased mortality risk, but its specific impact on physical and cognitive capabilities is less studied. A historical cohort study design was applied including married Tromsø study participants (N=5739) aged 50–70 years with baseline self-reported overall health and health-related factors and measured capability (grip strength, finger tapping, digit symbol coding, and short-term recall) at follow-up. Participants had data from Tromsø4 (1994–1995) and Tromsø5 (2001), or Tromsø6 (2007–2008) and Tromsø7 (2015–2016). Propensity score matching, adjusted for baseline confounders (and baseline capability in a subset), was used to investigate whether spousal bereavement was associated with poorer subsequent capability. Spousal bereavement occurred for 6.2% on average 3.7 years (SD 2.0) before the capability assessment. There were no significant bereavement effects on subsequent grip strength, immediate recall, or finger-tapping speed. Without adjustment for baseline digit symbol coding test performance, there was a negative significant effect on the digit symbol coding test (ATT −1.33; 95% confidence interval −2.57, −0.10), but when baseline digit symbol coding test performance was taken into account in a smaller subsample, using the same set of matching confounders, there was no longer any association (in the subsample ATT changed from −1.29 (95% CI −3.38, 0.80) to −0.04 (95% CI −1.83, 1.75). The results in our study suggest that spousal bereavement does not have long-term effects on the intrinsic capacity components physical or cognition capability to a notable degree.
The association between blood biological age at rehabilitation admission and physical activity during rehabilitation in geriatric inpatients: RESORT
Authors: Lu Jessica K. , Guan Lihuan , Wang Weilan , Rojer Anna G. M. , Galkin Fedor , Goh Jorming , Maier Andrea B. 
Published: April 2024

AbstractGeriatric rehabilitation inpatients have high levels of sedentary behaviour (SB) and low levels of physical activity (PA). Biological age predicted by blood biomarkers is indicative of adverse outcomes. The objective was to determine the association between blood biological age at rehabilitation admission and levels of SB and PA during rehabilitation in geriatric inpatients. Inpatients admitted to geriatric rehabilitation wards at the Royal Melbourne Hospital (Melbourne, Australia) from October 22, 2019, to March 29, 2020, in the REStORing health of acute unwell adulTs (RESORT) observational cohort were included. Blood biological age was predicted using SenoClock-BloodAge, a hematological ageing clock. Patients wore an inertial sensor to measure SB and PA. Logistic regression analyses were conducted. A total of 111 patients (57.7% female) with mean age 83.3 ± 7.5 years were included in the analysis. The mean blood biological age was 82.7 ± 8.4 years. Patients with 1-year higher blood biological age had higher odds of having high SB measured as non-upright time greater than 23 h/day (odds ratio (OR): 1.050, 95% confidence interval (CI): 1.000–1.102). Individuals having 1-year higher age deviation trended towards lower odds of having high levels of PA measured as stepping time greater than 7.4 min/day (OR: 0.916, CI: 0.836–1.005) and as greater than 19.5 sit-to-stand transitions/day (OR: 0.915, CI: 0.836–1.002). In conclusion, higher biological age was associated with higher levels of SB and trended towards lower PA. Incorporating blood biological age could facilitate resource allocation and the development of more tailored rehabilitation plans.
Situational Crime Prevention, Advice Giving, and Victim-Blaming
Authors: Holmen Sebastian Jon 
Published: April 2024

AbstractSituational crime prevention (SCP) measures attempt to prevent crime by reducing the opportunities for crime to occur. One of the ways in which some SCP measures reduce such opportunities is by providing victims with advice about how to avoid being victimised, for instance through public awareness campaigns or safety apps. Some scholars claim that this approach to preventing crime often or always promotes victim-blaming and that it is therefore morally wrong to pursue such strategies. Others have made sweeping rejections of this claim. However, in this paper, I suggest that neither view is correct. Specifically, I demonstrate that there are at least three distinct ways of interpreting what I term the victim-blaming argument against advice-giving SCP measures – i.e. as an argument based on a concern for direct victim-blaming, indirect victim-blaming, or self-blame – and that both SCP opponents and supporters have legitimate grounds for their position, depending on how the argument is spelled out.
Caring for the Critically Ill Adult Congenital Heart Disease Patient
Authors: Das Thomas , Rampersad Penelope , Ghobrial Joanna 
Published: April 2024

Abstract
Purpose of Review
This review aims to discuss the unique challenges that adult congenital heart disease (ACHD) patients present in the intensive care unit.

Recent Findings
Recent studies suggest that ACHD patients make up an increasing number of ICU admissions, and that their care greatly improves in centers with specialized ACHD care. Common reasons for admission include arrhythmia, hemorrhage, heart failure, and pulmonary disease.

Summary
It is critical that the modern intensivist understand not only the congenital anatomy and subsequent repairs an ACHD patient has undergone, but also how that anatomy can predispose the patient to critical illness. Additionally, intensivists should rely on a multidisciplinary team, which includes an ACHD specialist, in the care of these patients.
Limb-Clasping Response in NMDA Receptor Palmitoylation-Deficient Mice
Authors: Suzuki Nami , Oota-Ishigaki Akiko , Kaizuka Toshie , Itoh Masayuki , Yamazaki Maya , Natsume Rie , Abe Manabu , Sakimura Kenji , Mishina Masayoshi , Hayashi Takashi 
Published: April 2024

AbstractProper regulation of N-methyl-d-aspartate-type glutamate receptor (NMDA receptor) expression is responsible for excitatory synaptic functions in the mammalian brain. NMDA receptor dysfunction can cause various neuropsychiatric disorders and neurodegenerative diseases. Posttranslational protein S-palmitoylation, the covalent attachment of palmitic acid to intracellular cysteine residues via thioester bonds, occurs in the carboxyl terminus of GluN2B, which is the major regulatory NMDA receptor subunit. Mutations of three palmitoylatable cysteine residues in the membrane-proximal cluster of GluN2B to non-palmitoylatable serine (3CS) lead to the dephosphorylation of GluN2B Tyr1472 in the hippocampus and cerebral cortex, inducing a reduction in the surface expression of GluN2B-containig NMDA receptors. Furthermore, adult GluN2B 3CS homozygous mice demonstrated a definite clasping response without abnormalities in the gross brain structure, other neurological reflexes, or expression levels of synaptic proteins in the cerebrum. This behavioral disorder, observed in the GluN2B 3CS knock-in mice, indicated that complex higher brain functions are coordinated through the palmitoylation-dependent regulation of NMDA receptors in excitatory synapses.
Review of Iron-Based Catalysts for Carbon Dioxide Fischer–Tropsch Synthesis
Authors: Jia Ji-Yue , Shan Yu-Ling , Tuo Yong-Xiao , Yan Hao , Feng Xiang , Chen De 
Published: April 2024

AbstractCapturing and utilizing CO2 from the production process is the key to solving the excessive CO2 emission problem. CO2 hydrogenation with green hydrogen to produce olefins is an effective and promising way to utilize CO2 and produce valuable chemicals. The olefins can be produced by CO2 hydrogenation through two routes, i.e., CO2-FTS (carbon dioxide Fischer–Tropsch synthesis) and MeOH (methanol-mediated), among which CO2-FTS has significant advantages over MeOH in practical applications due to its relatively high CO2 conversion and low energy consumption potentials. However, the CO2-FTS faces challenges of difficult CO2 activation and low olefins selectivity. Iron-based catalysts are promising for CO2-FTS due to their dual functionality of catalyzing RWGS and CO-FTS reactions. This review summarizes the recent progress on iron-based catalysts for CO2 hydrogenation via the FTS route and analyzes the catalyst optimization from the perspectives of additives, active sites, and reaction mechanisms. Furthermore, we also outline principles and challenges for rational design of high-performance CO2-FTS catalysts.
Advertising a school’s merits in Hong Kong: weighing academic performance against students whole-person development
Authors: Ho Chun Sing Maxwell , Lu Jiafang , Liu Lucas Chiu Kit 
Published: April 2024

AbstractAgainst the background of expanding parental choices and declining global birth rates, schools are experiencing rising competition regarding student enrolment. Schools have responded by strategically presenting information about their students’ academic achievement and whole-person development orientation in the hope of attracting parents’ interest. However, few studies have investigated the impact of these factors on student enrollment, particularly in the context of diverse school types and educational orientations. Accordingly, this study utilized data from 327 secondary schools in Hong Kong to examine the effects of academic achievement orientation and whole-person development orientation on student intake. Using hierarchical regression analysis, we found a positive association between high whole-person development orientation and student intake in aided schools with a strong academic development orientation. The result implies parents are increasingly concerned about their children’s academic achievement and whole-person development at school. The study contributes to a broader understanding of the factors influencing parental choice in high-performing education systems, providing valuable insights for policymakers and educators seeking to improve educational offerings, enhance school transparency, and be better aligned with parental expectations.
Utilization of cotton gin waste biochars for agronomic benefits in soils
Authors: Howell Nathan , Bhattacharia Sanjoy , Aria Saman , Garcia Omar , Bednarz Craig , Guerrero Bridget 
Published: April 2024

AbstractCotton gin waste (CGW) is produced in large quantities (1–1.5 × 106 metric ton/year) in the Texas High Plains (THP), one of the largest cotton-producing regions in the USA. We examined locally supplied CGW for soil amendment as biochar (CGW-BC) with a view toward rainfed cropping systems, which will likely become increasingly necessary due to declines in groundwater availability for irrigation. Sixteen unique biochar samples were produced under varying conditions of time, temperature, and post-processing wash in a muffle furnace. We performed material characterization on the biochar. We then incubated CGW-BC samples that seemed favorable for increasing the water holding capacity increase for 10 days with local, rainfed, clay loam soil. We found that increasing the pyrolysis time and temperature decreased the biochar yield but only up to 40 min. Beyond 40 min, the yield did not decrease further. Additionally, the majority of mass loss occurred during pyrolysis and not during crush-sieving or postproduction washes. CGW-BC produced at higher temperatures and for longer times had greater thermal stability. This interesting aspect of thermal stability, which did not always follow strict time‒temperature trends, may be because cotton gin waste is a heterogeneous material. We found that the addition of acid decreases the mineral content while lowering the thermal stability of lower temperature (450 °C) biochars. Regarding the CGW-BC surface area, we found that higher temperatures generally increase the micropore surface area. Using a GAB isotherm, water vapor surface area did not correlate with the highest WHC when water was added to the soil. In fact, biochar, which was pyrolyzed in less time at a lower temperature and with the use of acid washing, better held the water in soil-biochar mixtures. The measurements suggested that CGW-BC could be a valuable soil amendment that could increase the WHC without adversely increasing the pH. Our initial investigation revealed how scaled-up production of CGW-BC for soils might be economically and sustainably pursued for use in rainfed cropping, deficit irrigation, or ranchlands.
Adsorption of anionic wood dyes on KOH-activated carbons from Pinus radiata sawdust
Authors: Pimentel Catarina Helena , Castro-Agra Rubén , Freire María Sonia , Gómez-Díaz Diego , González-Álvarez Julia 
Published: April 2024

Abstract
Chemically activated carbons synthesized from pine sawdust were applied efficiently for the elimination of wood dyes from aqueous solutions. Different proportions (1:2 and 1:4) of activating agent (KOH) and activation temperatures (600 and 850 °C) were used. Carbon surface morphology was characterized. The effect of pH (2–12), initial adsorbate concentration (5–500 mg L−1), and carbon dosage (0.1–0.5 g L−1) on dye adsorption were studied in batch mode. Langmuir model described well the adsorption equilibrium. The maximum found adsorption capacities were 1221.58, 1673.03, and 240.38 mg g−1 for blue and red at 500 mg L−1 and black at 100 mg L−1, respectively, using activated carbon at 850 °C and 1:4 (ACPS-4–850); at 25 °C, adsorbent dose 0.4 g L−1 for blue and black and 0.3 g L−1 for red dye and without change the pH for blue and red and at pH = 2 for black dye. The pseudo-second-order model explained the kinetics of adsorption except for the black dye at 100 mg L−1 using ACPS-4–850 for which it was the pseudo-first-order model. Desorption studies performed with ACPS-4–850 revealed that the adsorption was irreversible by chemical regeneration, whereas for the black dye, regeneration was efficient using H2O2 as desorbing agent.
Valuable Beyond Vulnerable: A Scoping Review on the Contributions of Older Forced Migrants in Post-migration Recovery
Authors: Ekoh Prince Chiagozie , Walsh Christine A. 
Published: April 2024

AbstractDuring times of crisis, including pandemics, climate change, and forced migration, much of the discourse in ageing research and intervention centers on the vulnerabilities of older adults. Unfortunately, the valuable contributions of older adults to post-disaster recovery and healing are often overlooked and undervalued. Our aim in this scoping review is to shed light on the critical contributions of older forced migrants to post-migration recovery. We set the scene by introducing the two significant global demographic changes of the twenty-first century: forced migration and ageing. We provide a discourse on older forced migrants, ageing in situations of forced migration, and some of the challenges faced by older forced migrants. We then present some of the substantial roles of older forced migrants in post-migration recovery, including building resilience, contributing to culture and language transfer, providing emotional support, offering mentorship and leadership, participating in community building, and fostering social integration. We close by highlighting some of the lessons that can be drawn from understanding the unique roles played by older adults in post-forced migration recovery and the key actions necessary to promote these roles.
Study on the compatibility of a treated effluent from automobile industry with conventional municipal activated sludge process
Authors: Peñas F. J. , Tapia M. E. , Vitas A. I. 
Published: April 2024

AbstractThe on-site-treated effluent from an automobile manufacturing company is discharged into the public sewage system for further treatment. However, the upgrade of the treatment plant to reduce the effluent pollutant load led to the discharge limit for phenols being occasionally exceeded. The concern of the water authority prompted a study to investigate whether the toxicity of phenols could affect the performance of the receiving municipal wastewater treatment plant. To this end, mixtures of the industrial effluent and synthetic municipal wastewater were tested in a laboratory-scale activated sludge system. The bioreactor was fed with increasing ratios of the industrial wastewater in the combined influent (from 10 to 50%) over 7 months. No significant differences were observed in the system performance fed only with the synthetic wastewater (during the acclimation stage) or with the industrial wastewater. The bioreactor achieved average removal efficiencies of 70% for phenols even when half of the combined influent was the industrial wastewater. Bearing in mind the question of phenols, an important drawback was the high uncertainty in their determination by the conventional phenol index method due to the matrix effect. To overcome this a spectrophotometric procedure based on the serial dilutions of each pair of influent and effluent samples has been developed. Although strong microbial selection was observed by the changing bioreactor environment, the industrial effluent was found to be fully compatible with further treatment by conventional activated sludge process.