bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of a fall detection device in older nursing home residents: a pilot study
Authors: Can Büşra , Tufan Aslı , Karadağ Şevval , DurmuŞ Nurdan Şentürk , Topçu Mümüne , Aysevinç Berrin , Düzel Songül Çeçen , Dağcıoğlu Sevda , AfŞar Fak Nazire , Tazegül Gökhan , Fak Ali Serdar 
Published: April 2024

AbstractBackgroundReal‐world research to evaluate the effect of device technology in preventing fall‐related morbidity is limited. This pilot study aims to investigate the effectiveness of a non‐wearable fall detection device in older nursing home residents.MethodsThe study was conducted in a nursing home with single‐resident rooms. Fall detection devices were randomly set up in half of the rooms. Demographic data, comorbidities, lists of medications, and functional, nutritional, and frailty status were recorded. The residents were followed up for 3 months. The primary outcome was falls and the secondary outcome was all‐cause mortality.ResultsA total of 26 participants were enrolled in the study. The study group consisted of 13 residents who had a fall detection device in their rooms. The remaining 13 residents on the same floor formed the control group. Participants had a mean age of 82 ± 10 years and 89% of the residents were female. The most prevalent comorbidity was dementia. Two residents from the control group and one resident from the study group experienced a fall event during follow‐up. The fall events in the control group were identified retrospectively by the nursing home staff, whereas the fall in the study group received a prompt response from the staff who were notified by the alarm. One resident was transferred to the hospital and died due to a non‐fall related reason.ConclusionDevice technology may provide an opportunity for timely intervention to prevent fall‐related morbidity in institutionalized older adults.
Treatment of horizontal neck wrinkles by Endolift laser: Biometric measurement
Authors: Nilforoushzadeh Mohammad Ali , Heidari‐Kharaji Maryam , Nobari Niloufar Najar , Torkamaniha Elham , Rafiee Shohreh , Shahverdi Mohammadhasan , Tehrani Sepideh , Fakhim Tannaz 
Published: April 2024

AbstractBackgroundOne of the common esthetic complaints of patients is horizontal neck wrinkles that have limited treatment modality.AimIn the present study, we evaluated the efficacy of the Endolift laser on the horizontal neck wrinkles.MethodsTotally, 10 healthy female and male patients suffering horizontal neck wrinkles were joined in this study. All patients are treated with Endolift laser. The effect of the Endolift methods on the horizontal neck wrinkles was evaluated by biometric parameter changed results with Cutometer, Visioface, and the Skin Ultrasound Imaging system. Also, three blinded dermatologists and patients’ satisfaction were evaluated.ResultsThe Visoface results showed that the Endolift laser treatment significantly decline the depth and area of horizontal neck wrinkle. The skin ultrasonography results reported the epidermis and dermis density and thickness were significantly increased. Also, the cutometer outcomes displayed that the Endolift laser treatment can increase skin elasticity. Also, significantly a greater number of patients were well satisfied with the technique.ConclusionIn conclusion, Endolift laser is a safe and effective method for decreasing the horizontal neck wrinkles and improving the appearance of the neck. This procedure does not require general anesthesia and recovery time.
Evaluation of the effects of adding an adipose tissue‐derived stromal vascular fraction to platelet‐rich plasma injection in the treatment of androgenetic alopecia: A randomized clinical trial
Authors: Behrangi Elham , Rahimi Seyyedeh Tahereh , Zare Sona , Goodarzi Azadeh , Ghassemi Mohammadreza , Khodadad Fariba , Nouri Maryam , Mozafarpoor Samaneh , Dehghani Abbas , Nilforoushzadeh Mohammad Ali , Roohaninasab Masoumeh 
Published: April 2024

AbstractBackgroundStromal vascular fraction (SVF) cells derived from adipose tissue and platelet‐rich plasma (PRP) are among novel treatments for androgenetic alopecia (AGA). We aimed to investigate the effect of adding SVF to PRP and compare it to administering PRP injection alone.MethodsEighteen patients were randomly divided into two groups of nine. The PRP group was treated with PRP at all three visits at 1‐month intervals, while the SVF‐PRP group received an SVF injection on the first visit and a PRP injection on the second and third visits. Each group was evaluated at baseline and 20 weeks after the therapy's initiation.ResultsChanges in mean hair diameter and hair count compared to baseline were significant in both groups. The PRP group experienced a greater increase in mean hair count than the SVF‐PRP group, and the SVF‐PRP group had a marginally greater increase in hair diameter than the PRP group. These differences were not statistically significant compared to each other. The patient and physician assessment scores exceeded the mean (on a scale from 0: poor to 3: excellent) in both groups.ConclusionAdding one SVF injection to two PRP treatment sessions versus three PRP injections alone had no significant difference in evaluated variables. If additional research demonstrates the same results, we suggest that multiple SVF injection sessions may be required to produce a statistically significant difference compared to PRP injection alone. Moreover, considering lower cost and greater accessibility of PRP, it can be used before SVF in the treatment of AGA.
Enhanced Detection of Syringe Defects Based on an Improved YOLOv7-Tiny Deep-Learning Model
Authors: Zhao Wenxuan , Wang Ling , Mao Chentao , Chen Xiai , Gao Yanfeng , Wang Binrui 
Published: April 2024

Abstract
The timely and accurate identification of syringe defects plays a key role in effectively improving product quality in production lines of syringes. In this article, we collected a dataset of image samples representing five common types of syringe defects found on the production line. The dataset comprises over 5000 images, with an average of three different syringe defects per image. Based on this dataset, we designed a syringe defect detection model based on an improved You Only Look Once Version 7 (YOLOv7)-Tiny proposed in this paper. The model combines the Res-PAN structure, the ACmix mixed attention mechanism, the FReLU activation function, and the SIoU loss function. The comparative experiments are conducted on the self-built dataset SYR-Dat to evaluate the performance of the proposed syringe defect detection model. The average precision of the model reaches 94.1%. To ensure the effectiveness of the model, it is compared with other models, including SSD300, Faster R-CNN, EfficientDet, RetinaNet, YOLOv5s, YOLOv6, and YOLOv7. The results demonstrate that the proposed improved YOLOv7-Tiny model can better capture the features of syringe defects. Furthermore, the generalization of the improved YOLOv7-Tiny model is validated on the VOC2012 dataset. The results indicate that the improved model continues to outperform the baseline models. The proposed syringe defect detection model shows promising application prospects, as it can reduce the rate of defective products and improve product quality.
Experimental Study and Creep-Fatigue Life Prediction of Turbine Blade Material DZ125 Considering the Nonholding Effect and Coupling Effect of Stress and High Temperature
Authors: Sun Debin , Wan Zhenhua 
Published: April 2024

Abstract
In response to the problem of creep-fatigue interaction damage failure of aero-engine turbine blade material, based on the modified damage evolution model of Kachanov-Rabotnov and Chaboche, a creep-fatigue life prediction model for nickel-based superalloy DZ125 is constructed considering the nonholding effect and coupling effect of stress and high temperature with the nonlinear interaction and superposition of creep damage and fatigue damage according to the continuum damage mechanics theory. Simultaneously, the microfracture morphology of DZ125 was analyzed using a scanning electron microscope, revealing the micromechanism of creep-fatigue interaction. The research results manifest that the creep-fatigue life prediction model has a high life prediction ability within ±2.0 times the dispersion band of the prediction results. Concurrently, a large number of intertwined tearing edges, microcracks, and microvoids appear in the fracture morphology, and creep and fatigue interact with each other in the form of effective stress. The above research can provide theoretical support for predicting the lifespan of mechanical structures in a high-temperature environment.
Complete genome of
Acinetobacter calcoaceticus
AC001_UM from Red River soil banks in Winnipeg, Manitoba, Canada
Authors: Wimalasekara Ruwani L. , Sykes Ellen M. E. , White Dawn , Rathgeber Chris , Kumar Ayush 
Published: April 2024

ABSTRACT

We report the whole-genome sequence and antibiotic-resistance gene profile of an
Acinetobacter calcoaceticus
isolate, designated AC001_UM, taken from soil along the Red River in Winnipeg, Manitoba, Canada. The genome comprised 3,916,544 nucleotides (GC content: 38.7%). Antibiotic-resistance gene analysis revealed a class D β-lactamase and three efflux pump families.
Renormalisation group running effects in $$pp\rightarrow t{\bar{t}}h$$ in the Standard Model Effective Field Theory
Authors: Di Noi Stefano , Gröber Ramona 
Published: April 2024

AbstractWe study the effects of renormalisation group running of the Wilson coefficients in Standard Model Effective Field Theory, using the process $$pp \rightarrow t {\bar{t}}h$$

p
p
→
t

t

¯

h

as a showcase. We consider both strong and top Yukawa running effects, since the latter can be relevant in presence of large Wilson coefficients. We study the difference between the use of a dynamical and fixed renormalisation scale by exploring different scenarios for the higher-dimensional operators at the high energy scale of new physics, assumed to be at the TeV scale.
Analytical Gaussian process cosmography: unveiling insights into matter-energy density parameter at present
Authors: Dinda Bikash R. 
Published: April 2024

AbstractIn this study, we introduce a novel analytical Gaussian Process (GP) cosmography methodology, leveraging the differentiable properties of GPs to derive key cosmological quantities analytically. Our approach combines cosmic chronometer (CC) Hubble parameter data with growth rate (f) observations to constrain the $$\Omega _{\textrm{m0}}$$

Ω
m0

parameter, offering insights into the underlying dynamics of the Universe. By formulating a consistency relation independent of specific cosmological models, we analyze under a flat FLRW metric and first-order Newtonian perturbation theory framework. Our analytical approach simplifies the process of Gaussian Process regression (GPR), providing a more efficient means of handling large datasets while offering deeper interpretability of results. We demonstrate the effectiveness of our methodology by deriving precise constraints on $$\Omega _{\textrm{m0}}h^2$$

Ω
m0

h
2

, revealing $$\Omega _\textrm{m0}h^2=0.139\pm 0.017$$

Ω
m0

h
2

=
0.139
±
0.017

. Moreover, leveraging $$H_0$$

H
0

observations, we further constrain $$\Omega _{\textrm{m0}}$$

Ω
m0

, uncovering an inverse correlation between mean $$H_0$$

H
0

and $$\Omega _{\textrm{m0}}$$

Ω
m0

. Our investigation offers a proof of concept for analytical GP cosmography, highlighting the advantages of analytical methods in cosmological parameter estimation.
Omental Preadipocytes Stimulate Matrix Remodeling and IGF Signaling to Support Ovarian Cancer Metastasis
Authors: Waters Jennifer A. , Robinson Mikella , Lujano-Olazaba Omar , Lucht Cassidy , Gilbert Samuel F. , House Carrie D. 
Published: April 2024

AbstractOvarian cancer can metastasize to the omentum, which is associated with a complex tumor microenvironment. Omental stromal cells facilitate ovarian cancer colonization by secreting cytokines and growth factors. An improved understanding of the tumor-supportive functions of specific cell populations in the omentum could identify strategies to prevent and treat ovarian cancer metastasis. Here, we showed that omental preadipocytes enhance the tumor initiation capacity of ovarian cancer cells. Secreted factors from preadipocytes supported cancer cell viability during nutrient and isolation stress and enabled prolonged proliferation. Coculturing with preadipocytes led to the upregulation of genes involved in extracellular matrix (ECM) organization, cellular response to stress, and regulation of insulin-like growth factor (IGF) signaling in ovarian cancer cells. IGF1 induced ECM genes and increased alternative NF-κB signaling by activating RelB. Inhibiting the IGF1 receptor initially increased tumor omental adhesion but decreased the growth of established preadipocyte-induced subcutaneous tumors as well as established intraperitoneal tumors. Together, this study shows that omental preadipocytes support ovarian cancer progression, which has implications for targeting metastasis.Significance: Omental preadipocyte-mediated IGF1 signaling promotes ovarian cancer tumorigenesis and metastasis via extracellular matrix remodeling, revealing a role for preadipocytes in regulating ovarian cancer progression and highlighting potential therapeutic targets for metastatic disease.
CD58 Alterations Govern Antitumor Immune Responses by Inducing PDL1 and IDO in Diffuse Large B-Cell Lymphoma
Authors: Xu Xiyue , Zhang Yidan , Lu Yaxiao , Zhang Xiaoyan , Zhao Cuicui , Wang Jiesong , Guan Qingpei , Feng Yingfang , Gao Meng , Yu Jingwei , Song Zheng , Liu Xia , Golchehre Zahra , Li Lanfang , Ren Weicheng , Pan-Hammarström Qiang , Zhang Huilai , Wang Xianhuo 
Published: April 2024

Abstract
Recurrent abnormalities in immune surveillance–related genes affect the progression of diffuse large B-cell lymphoma (DLBCL) and modulate the response to therapeutic interventions. CD58 interacts with the CD2 receptor on T cells and NK cells and is recurrently mutated and deleted in DLBCL, suggesting that it may play a role in regulating antitumor immunity. In this study, we comprehensively analyzed the genomic characteristics of CD58 through targeted next-generation sequencing, RNA sequencing (RNA-seq), whole-exome sequencing, and single-cell RNA-seq in patients with newly diagnosed DLBCL. The CD58 mutation rate was 9.1%, and the copy number loss rate was 44.7% among all enrolled patients with DLBCL. Notably, CD58 genetic alterations, along with low CD58 expression, significantly correlated with reduced rates of response to R-CHOP therapy and inferior progression-free survival and overall survival. Single-cell RNA-seq revealed that CD58 expression in tumor cells was negatively correlated with CD8+ T-cell exhaustion/dysfunction status. Insufficient T-cell activation resulting from CD58 alterations could not be attributed solely to CD2 signaling. CD58 inhibited the activity of the JAK2/STAT1 pathway by activating the LYN/CD22/SH2 domain–containing phosphatase 1 (SHP1) axis, thereby limiting PDL1 and IDO expression. Elevated PDL1 and IDO expression in CD58-deficient DLBCL cells led to immune evasion and tumor-intrinsic resistance to chimeric antigen receptor T-cell therapy. Direct activation of CD58–CD2 costimulatory signaling in combination with anti-PDL1 blockade or IDO inhibitor sensitized CD58-deficient DLBCL to chimeric antigen receptor T-cell therapy. Collectively, this work identified the multiple roles of CD58 in regulating antitumor immune responses in DLBCL.
Significance: Loss of CD58 mediates immune evasion and therapy resistance in diffuse large B-cell lymphoma by upregulating PDL1 and IDO through LYN/CD22/SHP1 signaling, providing potential targets and therapeutic strategies to improve patient treatment.
Optimizing the Design and Geometry of T Cell–Engaging Bispecific Antibodies Targeting CEA in Colorectal Cancer
Authors: Elsayed Abdullah , Plüss Louis , Nideroest Larissa , Rotta Giulia , Thoma Marina , Zangger Nathan , Peissert Frederik , Pfister Stefanie K. , Pellegrino Christian , Dakhel Plaza Sheila , De Luca Roberto , Manz Markus G. , Oxenius Annette , Puca Emanuele , Halin Cornelia , Neri Dario 
Published: April 2024

Abstract
Metastatic colorectal cancer remains a leading cause of cancer-related deaths, with a 5-year survival rate of only 15%. T cell–engaging bispecific antibodies (TCBs) represent a class of biopharmaceuticals that redirect cytotoxic T cells toward tumor cells, thereby turning immunologically “cold” tumors into “hot” ones. The carcinoembryonic antigen (CEA) is an attractive tumor-associated antigen that is overexpressed in more than 98% of patients with colorectal cancer. In this study, we report the comparison of four different TCB formats employing the antibodies F4 (targeting human CEA) and 2C11 (targeting mouse CD3ε). These formats include both antibody fragment–based and IgG-based constructs, with either one or two binding specificities of the respective antibodies. The 2 + 1 arrangement, using an anti-CEA single-chain diabody fused to an anti-CD3 single-chain variable fragment, emerged as the most potent design, showing tumor killing at subnanomolar concentrations across three different CEA+ cell lines. The in vitro activity was three times greater in C57BL/6 mouse colon adenocarcinoma cells (MC38) expressing high levels of CEA compared with those expressing low levels, highlighting the impact of CEA density in this assay. The optimal TCB candidate was tested in two different immunocompetent mouse models of colorectal cancer and showed tumor growth retardation. Ex vivo analysis of tumor infiltrates showed an increase in CD4+ and CD8+ T cells upon TCB treatment. This study suggests that bivalent tumor targeting, monovalent T-cell targeting, and a short spatial separation are promising characteristics for CEA-targeting TCBs.
Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans
Authors: Diez Benavente Ernest , Hartman Robin J.G. , Sakkers Tim R. , Wesseling Marian , Sloots Yannicke , Slenders Lotte , Boltjes Arjan , Mol Barend M. , de Borst Gert J. , de Kleijn Dominique P.V. , Prange Koen H.M. , de Winther Menno P.J. , Kuiper Johan , Civelek Mete , van der Laan Sander W. , Horvath Steve , Onland-Moret N. Charlotte , Mokry Michal , Pasterkamp Gerard , den Ruijter Hester M. 
Published: April 2024

BACKGROUND:
Epigenetic age estimators (clocks) are predictive of human mortality risk. However, it is not yet known whether the epigenetic age of atherosclerotic plaques is predictive for the risk of cardiovascular events.

METHODS:
Whole-genome DNA methylation of human carotid atherosclerotic plaques (n=485) and of blood (n=93) from the Athero-Express endarterectomy cohort was used to calculate epigenetic age acceleration (EAA). EAA was linked to clinical characteristics, plaque histology, and future cardiovascular events (n=136). We studied whole-genome DNA methylation and bulk and single-cell transcriptomics to uncover molecular mechanisms of plaque EAA. We experimentally confirmed our in silico findings using in vitro experiments in primary human coronary endothelial cells.

RESULTS:

Male and female patients with severe atherosclerosis had a median chronological age of 69 years. The median epigenetic age was 65 years in females (median EAA, −2.2 [interquartile range, −4.3 to 2.2] years) and 68 years in males (median EAA, −0.3 [interquartile range, −2.9 to 3.8] years). Patients with diabetes and a high body mass index had higher plaque EAA. Increased EAA of plaque predicted future events in a 3-year follow-up in a Cox regression model (univariate hazard ratio, 1.7;
P
=0.0034) and adjusted multivariate model (hazard ratio, 1.56;
P
=0.02). Plaque EAA predicted outcome independent of blood EAA (hazard ratio, 1.3;
P
=0.018) and of plaque hemorrhage (hazard ratio, 1.7;
P
=0.02). Single-cell RNA sequencing in plaque samples from 46 patients in the same cohort revealed smooth muscle and endothelial cells as important cell types in plaque EAA. Endothelial-to-mesenchymal transition was associated with EAA, which was experimentally confirmed by
TGFβ
-triggered endothelial-to-mesenchymal transition inducing rapid epigenetic aging in coronary endothelial cells.

CONCLUSIONS:
Plaque EAA is a strong and independent marker of poor outcome in patients with severe atherosclerosis. Plaque EAA was linked to mesenchymal endothelial and smooth muscle cells. Endothelial-to-mesenchymal transition was associated with EAA, which was experimentally validated. Epigenetic aging mechanisms may provide new targets for treatments that reduce atherosclerosis complications.
Dynamic fluctuations of salivary CGRP levels during migraine attacks: association with clinical variables and phenotypic characterization
Authors: Alpuente Alicia , Gallardo Victor J. , Asskour Laila , Caronna Edoardo , Torres-Ferrus Marta , Pozo-Rosich Patricia 
Published: April 2024

Abstract
Background
Migraine is a complex neurological disorder with significant heterogeneity in its clinical presentation and molecular mechanisms. Calcitonin gene-related peptide (CGRP) has emerged as a key player in migraine pathophysiology, but challenges remain in its utilization as a biomarker. This study aimed to investigate salivary CGRP levels during migraine attacks across the frequency spectrum and explore associations with clinical variables.

Methods
A prospective longitudinal pilot study was conducted, recruiting migraine patients from an outpatient headache clinic. Salivary CGRP levels were measured at interictal, onset, post-2 h of onset and end-of-attack. Using generalized linear mixed models, we explored the effect of CGRP changes over the attack in presence of depressive symptoms (DS), acute attack treatment, and after three-months of erenumab treatment. Finally, patients were classified and compared according to their CGRP phenotype.

Results
A total of 44 migraine patients were included (90.9% women), with 80 migraine attacks analyzed. Salivary CGRP levels increased at the onset of migraine attacks. We observed statistically significant interactions between DS and both the linear (Est. [SE]: 19.4 [5.8], p = 0.001) and quadratic terms of time (-19.1 [6.0], p = 0.002). Additionally, a significant three-way interaction within the use of acute treated attack (linear-term: -18.5 [6.2], p = 0.005; quadratic-term: 19.2 [6.8], p = 0.005) was also found. Molecular phenotyping revealed that 72.7% (32/44) of patients presented only CGRP-dependent attacks, while 27.3% (12/44) presented non-CGRP-dependent migraine attacks. Patients with only CGRP-dependent attacks were associated with younger age, shorter disease evolution time, a higher proportion of aura, and fewer monthly headache days (p < 0.05). Exploratory analysis of erenumab treatment effects did not result in changes in CGRP levels during migraine attacks.

Conclusions
Our study underscores the dynamic nature of migraine at a molecular level and emphasizes the importance of integrating clinical variables, such as depressive symptoms, in understanding its pathophysiology. The identification of distinct migraine subtypes based on CGRP dependence suggests potential opportunities for personalized treatment approaches.