bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rheumatoid Vasculitis and Blepharitis Caused By Rheumatoid Arthritis In 6 Years Old Boy: A Case Report
Authors: Lawang Sitti Aizah , Hakka Hasriani Muhammad , Nurdin Mulawardi Muhammad , Maulani Destya 
Published: March 2024

Link of Video Abstract: https://youtu.be/4Guk_6foSxw

Introduction: Rheumatoid Vasculitis (RV) is a rare complication affecting approximately 1% of patients with severe rheumatoid arthritis. This condition is an extra-articular manifestation of rheumatoid arthritis that affects the small and medium arteries in the body. Vasculitis is an inflammatory necrotizing vascular wall disease that can occur in autoimmune disease. This inflammation leads to damage in blood vessels due to stenosis or occlusion and thrombosis, resulting in pain, necrosis, and aneurysm. Inflammation can be primary or secondary. Skin, fingers, peripheral nerves, eyes and the heart are the most commonly affected areas.
Case description: We report a case of a 6-year-old boy who presented RV and blepharitis. The patient subsequently experienced nail fold infarcts and gangrene of his left finger. He was found to fulfill Jones Criteria, and treatment with aspirin and corticosteroids significantly improved his symptoms. This rare case describes the early onset of rheumatoid vasculitis in a patient with rheumatoid arthritis. Rheumatoid vasculitis is a systemic disease that develops from rheumatoid arthritis with rheumatoid autoantibodies and extra-articular manifestations characterized by tissue damage or ischemia involving the skin and peripheral nerves. The incidence of rheumatoid vasculitis in children is less than 1%, with 12 to 53 cases per 100,000 children under 17 years old.
Conclusion: Rheumatoid vasculitis is a rare complication of rheumatoid. This condition occurs in patients who have rheumatoid arthritis for a long period. The patient will prevent further complications with early diagnostic and proper treatment.
Scoring system for predicting the Post-Operative Atrial Fibrillation (POAF) in post-cardiac surgery: a literature review
Authors: Puspitasari Rahajeng Arianggarini , Sembiring Yan Efrata , Sembiring Joan Angelina 
Published: March 2024

Link of Video Abstract: https://youtu.be/tl9Q8g6DUdcBackground: Coronary artery bypass grafting (CABG) is still one of the optimal treatment options for revascularization in coronary heart disease. Despite Atrial Fibrillation being the most common arrhythmia after CABG, there’s still no agreement on which risk assessment to predict the incidence of Post Operative Atrial Fibrillation (POAF). Some studies have shown that the findings of Atrial fibrillation after CABG are associated with increased hemodynamic disturbances, thromboembolic manifestations, readmission to the Intensive Care Unit (ICU), increased length of stay, organ failure, and death. This study aims to analyze the scoring system used for predicting the incidence of POAF in cardiac surgery.
Methods: This study used “POAF” AND “Scoring system," AND "CABG” AND “Atrial Fibrillation” as keywords to explore the literature from PubMed, Google Scholar, ProQuest, and Clinical Key. Search engines were searched for relevant papers from the last 15 years.
Result: CHA2DS2-VASc score has a sensitivity of 74.2%, a specificity of 44.7% and can identify patients who are predicted to have a high risk of experiencing POAF by 49.4%. The CHA2DS2-VASc score can be used as an independent predictor for predicting POAF. HATCH score cut-off point exceeding 1 was linked to AF prediction, yielding a sensitivity of 42% and specificity of 70%. POAF Score, the scoring system anticipates an increased likelihood of POAF development (58.5%). A score of 1 corresponds to a 30.1% probability of POAF occurrence and is a practical point for commencing preventive therapy.
Conclusion: Despite the various scoring systems used to predict postoperative atrial fibrillation, including the CHA2DS2-VASc score, HATCH score and Mariscalco. POAF Score demonstrated a validated ability to predict POAF.
Supplementation of vitamin D reduces energy intake and prevents body fatness accumulation in obese woman
Authors: Sinto Linda , I Wayan Weta  , Komang Bagus Satriasa  , Nyoman Mantik Astawa  
Published: March 2024

Link of Video Abstract: https://youtu.be/bqtP9eagX1E

Introduction: Obese people are at higher risk of comorbidities, including metabolic syndrome, autoimmune, tumor progression and other inflammation diseases because of low-grade chronic inflammation. Vitamin D is closely related to transcriptional activity in adipose tissue, which regulates adipogenesis, inflammatory pathways, and adipose cell metabolism. This research aims to know the effect of Vitamin D supplementation on energy intake and body fat accumulation.
Methods: 40 obese women between the ages of 26 and 45 were randomly assigned to the Intervention and Control groups, which received daily supplements of 5000 IU of vitamin D and a placebo, respectively. Data were gathered before the intervention and after 12 weeks of it. We measured the energy intake, BMI, waist circumference (WC), and conicity index. The participants were told to keep their daily calorie consumption at or below 1500 kcal.
Results: After 12 weeks of supplementation, 25(OH) Vitamin D levels increased significantly (p=0.001), and energy intake decreased (p=0.014) significantly in the intervention group, but no change in the control group (p>0,05). Body fatness indices (BMI and WC) increased (p=0.005 and p=0.003) significantly in the control group; however, these parameters did not change in the intervention group (p>0.05).
Conclusion: Daily Vitamin D 5000 IU for 12 weeks decreases energy intake and prevents body fat accumulation in obese women.
A systematic review of natural resistance-associated macrophage protein 1 (NRAMP1) gene and susceptibility to tuberculosis: What is the link for ocular tuberculosis?
Authors: Amalius Ahmad Ashraf , Budu  , Massi Muh. Nasrum , Umar Batari Todja , Minhajat Rahmawati , Muis Mirna , Handayani Irda , Hidayah Najdah 
Published: March 2024

Link of Video Abstract: https://youtu.be/hxFKCtWwc3c

Introduction: The host genetic factors play a crucial role in determining susceptibility to tuberculosis (TB), and one such candidate gene is Natural Resistance-Associated Macrophage Protein 1 (NRAMP1). NRAMP1 is involved in the regulation of intracellular iron homeostasis, an essential nutrient for MTb survival within macrophages. Several polymorphisms of the NRAMP1 gene have been extensively studied for their association with TB susceptibility. However, the specific role of these NRAMP1 gene polymorphisms in the development of ocular tuberculosis, a rare but potentially severe form of TB, remains poorly understood.
Methods: This study was a systematic review conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA). A comprehensive search was performed in the PubMed, Cochrane, and Science Direct databases for original, full-text studies of NRAMP1 gene related to tuberculosis infection. Ethnic, polymorphisms of NRAMP1 evaluated, and its association to TB susceptibility were recorded and summarized qualitatively.
Results: There were 41 studies included in our systematic review. No study of NRAMP1 gene polymorphism in regards to ocular tuberculosis was found. Polymorphisms of the NRAMP1 gene, such as 3'UTR TGTG ins/del, D543N, INT4, and (GT)n, have been investigated for their potential role in determining the susceptibility or immunity to Mycobacterium tuberculosis infection. However, the findings regarding the relationship between NRAMP1 gene polymorphism and tuberculosis are still inconsistent, with controversies and discrepancies among different studies.
Conclusion: NRAMP1 gene polymorphisms showed important involvement to tuberculosis infection susceptibility, therefore its relation to ocular tuberculosis is suggested.
Three years’ experience of tuberculosis versus non-tuberculosis cases of bronchopleural fistula repair at Dr. Soetomo General Academic Hospital Surabaya
Authors: Giriastawa I Gusti Bagus Chandogya , Winarno Dhihintia Jiwangga Suta , Rizki Mohamad 
Published: March 2024

Link of Video Abstract: https://youtu.be/DVqGIPOyWR0

Background: Tuberculosis (TB) continues to be a significant health issue and causes various complications, especially in developing countries. Bronchopleural fistula (BPF) is a rare and potentially life-threatening complication of pulmonary tuberculosis that needs to be treated by surgical procedure. This research aimed to compare the outcome of post-operative BPF repair caused by Tuberculosis and non-Tuberculosis cases.
Methods: In this retrospective review, we include patients from post-operative repair of BPF with Tuberculosis and non-Tuberculosis cases from January 2020 to December 2022 who were admitted to our primary center. Preoperative, operative and postoperative data were collected from medical records. We identified 36 patients and analyzed the differences between TB and non-TB groups.
Results: There were 36 patients with BPF who underwent surgery. The mean age of the subjects was 47.940±15.288 years. Out of these, 25 subjects (69.4%) had TB, while 11 (30.6%) subjects did not. Among the subjects, 14 TB patients (38.9%) and 2 non-TB patients (56%) experienced recurrent pneumothorax before surgery. Statistical analysis showed a significant association between comorbid TB and the occurrence of secondary attack BPF before surgery (p = 0.035). Regarding the duration of post-operative drain placement, 22 TB patients (61.1%) had the drain placed for less than 7 days, while 3 subjects (8.3%) had it for more than 7 days. Among the non-TB patients, 10 subjects (27.8%) had the drain placed for less than 7 days, and only 1 subject (2.8%) had it for more than 7 days. The statistical analysis showed no association between the TB group and the duration of post-operative drain placement (p=0.798).
Conclusion: There are numerous post-operative complications and morbidities following BPF repair surgery. Patients with TB who undergo BPF repair surgery are significantly associated with secondary attack BPF before surgery.
Profile of ameloblastoma patients at Dr. Soetomo general hospital, Surabaya: A descriptive study
Authors: Hidayat Muhammad Furqan , Marjono Dwi Wibowo  
Published: March 2024

Link of Video Abstract: https://youtu.be/_nqEUazGnE0

Background: Ameloblastoma is a rare odontogenic epithelial tumor affecting the jawbone (maxilla or mandible). According to the WHO in 2005, there are four different classifications of ameloblastoma: solid or multicystic, unicystic, peripheral, and desmoplastic. Despite being benign, ameloblastoma can seriously damage bones, resulting in deformity and even death. This research aims to know the profile of ameloblastoma due to limited data in Indonesia.
Methods: This study is an observational descriptive study. Cross-sectional data collection was used. Information was gathered from the medical records of patients with ameloblastoma treated at Dr. Soetomo general hospital, Surabaya between January 2018 and December 2022. A descriptive analysis was conducted to determine the frequency and proportion of each research variable.
Results: Forty-two ameloblastoma patients participated in the study. Patients with ameloblastoma ranged in age from 14 to 75, with a mean age of 39.6 (15.7) years. The majority of patients (57.1%) were female. The majority of the cases were mandibular ameloblastoma. Only 4.8% of ameloblastoma cases occurred in the maxilla, while 76.2% of ameloblastoma locations were found in the left mandible. Up to 97.61% of the surgeries conducted include extensive resection. Most patients (95.2%) with ameloblastoma had successful outcomes.
Conclusion: Although rare, the profile of ameloblastoma patients reveals that there are still incidences of fatality, necessitating further discussion of patient mortality risk factors.
Epidemiological description of the risk factors for obstetric emergencies in cross-referral cases at Dr. Soetomo Regional Public Hospital during the COVID-19 pandemic from 2020 to 2021
Authors: Heky Albar , Prasetyo Budi , Damayanti Hanifa Erlin , Djuari Lilik 
Published: March 2024

Link Of Video Abstract: https://youtu.be/zIVTZc6xl_8

Introduction: Emergency obstetric referrals are crucial for preventing pregnancy complications that may escalate into severe, life-threatening conditions, ultimately resulting in fatalities. The pandemic influenced the obstetric referral system of healthcare services. Specifically, Dr. Soetomo Regional Public Hospital recorded 107 cross-referral cases in 2020 and 58 in 2021 with obstetric risk factors. In this study, we analyze these obstetric emergency cross-referral cases during the pandemic at the hospital. This study aims to provide an epidemiological description of cross-referral cases with risk factors for obstetric emergencies at Dr. Soetomo Regional Public Hospital during the COVID-19 pandemic from 2020 to 2021.
Methods: An analytical descriptive research design, employing a case study approach, was used to analyze cross-referral cases with risk factors for obstetric emergencies over the pandemic period. The research subjects encompassed all obstetric emergency cross-referral cases at Dr. Soetomo Regional Public Hospital during the pandemic, with a total sampling technique applied to select cases that met specific inclusion and exclusion criteria.
Results: The analysis of emergency obstetric referrals revealed a significant relationship between the patient’s age and their risk factor categories for obstetric emergencies (p < 0.001). Furthermore, a significant correlation was found between the delayed referral phases and the risk factors for obstetric emergencies (p < 0.001). A significant correlation was observed concerning the need for Intensive Care Unit (ICU) care. The analysis also demonstrated a significant relationship between obstetric emergencies and birth weight as well as APGAR score (p < 0.05).
Conclusion: This study reveals a compelling relationship between the risk factors for obstetric emergencies and the variables such as age, methods of vaginal delivery, delayed referral phases, birth weights, and APGAR scores during the COVID-19 pandemic.
Ascorbic acid and calcitriol reduce TNF-α to improve the viability of modified McFarlane random skin flaps in Wistar rats
Authors: Santoso Rosalyn Devina , Hamid Agus Roy Rusly Hariantana , Mahadewa Tjokorda Gde Bagus , Sanjaya I Gusti Putu Hendra , Budayanti Ni Nyoman Sri , Herawati Sianny 
Published: March 2024

Link of Video Abstract: https://youtu.be/8UIEdUv8za8

Introduction: Distal flap necrosis is one of the most common complications in flap procedure. Ascorbic acid (vitamin C) is one of the most widespread antioxidants available, while calcitriol, a metabolite of vitamin D, has anti-inflammatory and antioxidant properties. The purpose of this study was to determine the effect of ascorbic acid and calcitriol on the viability of Modified McFarlane random skin flaps in Wistar rats and its mechanism through suppression of proinflammatory cytokine Tumor Necrosis Factor-α (TNF-α).
Methods: An experimental study used 28 Wistar rats, by creating a caudally based 3 cm x 9 cm Modified McFarlane random skin flap and divided into four groups. The first group was injected with 200 mg/kg/day ascorbic acid, the second group with 2μg/kg/day calcitriol, and the third group with 200 mg/kg/day ascorbic acid combined with 2μg/kg/day calcitriol was injected two hours after flap elevation for seven days, respectively. The control group was not given any intraperitoneal injection. After seven days, the percentage of flap viability rate was measured and tissue sampling was performed to measure the amount of capillary density and TNF-α in all groups.
Results: The higher percentage of viable flap area was found in all treatment groups, the highest in the ascorbic acid group 80.63% (p<0.001). The highest capillary density was found in ascorbic acid combined with the calcitriol group (27/visual field, p<0.001) compared to all groups. It was also found that the amount of TNF-α in the tissue was lowest in the group administered by ascorbic acid combined with calcitriol compared to all groups 57.38 ng/L and 0.62 nmol/mL respectively compared to all groups (p<0.001). The higher percentage of viable flap area was correlated with a lower amount of TNF-α (p<0.001), but not correlated with the amount of capillary density (p>0.05).
Conclusion: Ascorbic acid in combination with calcitriol improves the viability of Modified McFarlane random skin flaps by lowering TNF-α levels.
Comparative study of bioactive compound content and antioxidant activity in different extraction methods of Syzygium Polyanthum leaves
Authors: Aditya Renny , Santoso Budi , Widjiati Widjiati 
Published: March 2024

Link of Video Abstract: https://youtu.be/VtCPJX9TPg4

Background : Syzygium Polyanthum is classified among the 5,000 medicinal plant species documented in the Indonesian Medicinal Herb Index. It is utilised for a variety of purposes in traditional medicine and has potential health benefits. Extraction of medicinal plants is crucial to separate active plant materials or secondary metabolites. The aim of the study was to compare extracts of Syzygium Polyanthum Leaves using different methods: maceration and UAE in extracting flavonoids, phenolic compounds and antioxidant activity.
Methods: the bioactive component content and antioxidant activity of Syzygium polyanthum leaves extracted using two different methods—maceration and ultrasound-assisted extraction (UAE)—are compared. 96% ethanol was employed as the extracting solvent in the maceration and UAE extraction processes for S. polyanthum.The bioactive substances in both extracts were determined using Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS).
Result: The amount of total phenolic, flavonoid, and IC50 in S. polyanthum leaves was evaluated between the maceration extraction method and UAE. Liquid chromatography-high Resolution Mass Spectrometry (LC-HRMS) analysis was utilized to detect the presence of bioactive compounds, then classified according to the PubChem database's taxonomy. There were comparable amounts of flavonoids in both extracts (60.194 mg QE/g and 60.074 mg QE/g). According to the DPPH assay, the total phenol for the extracts obtained by maceration and UAE was 94.63 ± 2.18 mg GAE/g and 122.87 ± 5.99 mg GAE/g extracts respectively, and the IC50 for the extracts obtained by maceration and UAE were 88.21 ± 1.38 μg/mL and 41.23 ± 6.11 μg/mL.
Conclusion: The findings of the study indicated that the ultrasonic-assisted extraction (UAE) approach yielded significantly greater quantities of total phenolic and flavonoid compounds, as well as exhibited stronger antioxidant activity, when compared to the maceration extraction method. The utilisation of the UAE approach resulted in a significant rise in the antioxidant activity of S. polyanthum leaves.
Health belief model approach in reducing worm infections in elementerary school in North Aceh, Indonesia
Authors: Sofia Rizka , Yuziani Yuziani , Utariningsih Wheny 
Published: March 2024

Link of Video Abstract: https://youtu.be/xwXNgnCdD_g

Introduction: The prevalence of worm infections in Indonesia is still relatively high, about 2.5% - 62%, depending on geographical conditions, education, economics, environmental sanitation and community hygiene. Elementary school students have an increased risk of worm infections due to personal hygiene and environmental factors which cause high levels of worm infections in students. Implementing the health belief model (HBM) will be a model for identifying public understanding regarding preventive and promotive efforts to reduce the risk of worm infections. This study aims to determine the application of the HBM for reducing worm infections in elementary school students in Lapang sub-district in North Aceh.
Method: This type of research is a purposive sampling with a cross sectional design. A number of 120 respondents are from elementary school in Lapang sub-district, HBM was measured by using a questionnaire. Worm infection was determined from the results of fecal examination using the direct slide method.
Results: The results found that 45.8% students experienced worm infections, majority's perception of susceptibility to worm infections (67,3%), perception of seriousness (65,5%), and perception of benefits (65,5%) were in low category but perception of barriers was in high category (58,2%). HBM Assessment Analysis on perceived vulnerability shows a p-value of 0.020, perceived seriousness shows 0.034, perceived obstacles show 0.021, and perceived benefits shows 0.022. The four HBM concept assessments have a value of p<0.05.
Conclusion: The results concluded that the Ho meaning was accepted which there was a relationship between HBM and the reduction of worm infections.
Melatonin, an adjuvant for neonatal sepsis: a systematic review and meta-analysis
Authors: Hidayah Dwi , Harsono Salimo  , Tunjung Wibowo  , Brian Wasita  , Vitri Widyaningsih  , Hartono Hartono , Soetrisno Soetrisno  
Published: March 2024

Link of Video Abstract: https://youtu.be/QMfynOrGWxM

Introduction: Neonatal sepsis remains a serious health problem in some countries, especially in developing countries, like Indonesia. The standard treatment for sepsis is the administration of antibiotics. Melatonin, a hormone produced by the pineal gland, has beneficial effects in fighting free radicals, antioxidants, anti-inflammatory, and anti-apoptotic effects. However, in newborns, melatonin is minimally detectable. Adjuvant therapy is required for the deterrence and neonatal sepsis therapy. This study aims to systematically review and perform a meta-analysis of melatonin as an adjunctive therapy in treating neonatal sepsis with the addition of the most recent articles.
Methods: Databases of electronics used such as PubMed, Embase, and the Cochrane Central Controlled Trials Register were searched systematically in October 2022 for clinical trials reporting the efficacy of melatonin as adjunctive therapy for neonatal sepsis. We compared treatment responses between groups using serum C-reactive protein (CRP) levels as an endpoint biomarker. Data analysis was performed to appraise the quality of enrolled studies using a comprehensive meta-analysis Revman 5.4 and bias tool risk of the Cochrane Collaboration.
Results: Four trials with a total of 175 subjects were listed in the systematic review and meta-analysis. Pooled analysis showed a statistically significant mean difference in serum CRP level (mg/L) between groups 24 hours after adjuvant melatonin therapy (-1.63 mg/L; 95% CI: -3.20 to -0.054; P=0.043).
Conclusion: Melatonin as an adjunctive therapy significantly lowers CRP levels. Larger, sample size studies are necessary to establish clear clinical benefits of this treatment.