bluuebunny/crossref_metadata_2025_split huggingface dataset:
Checklist of symbionts in Hyalella (Amphipoda, Hyalellidae) from South America
Authors: Rauque Carlos , Hidalgo Alejandro , De los Ríos-Escalante Patricio 
Published: February 2024

Abstract
Despite their ecological importance, research on symbionts of amphipods has been limited in South America. The present study provides a comprehensive overview of symbiont organisms in the freshwater amphipods of the genus Hyalella in South America. Our findings reveal various taxa such as Apicomplexa, Microspora, Peritrichia, Folliculinidae, trematodes, nematodes, cestodes and acanthocephalans, often involving complex life cycles. Studies on symbionts have been done almost exclusively in Argentinean Patagonia. The present overview allows us to know the species that use amphipods, to elucidate their lifecycles and to know their occurrence values.
The effects of physical activity on the modulation of gut microbiota composition: a systematic review
Authors: Lavilla-Lerma M.L. , Aibar-Almazán A. , Martı́nez-Amat A. , Benomar-El-Bakali N. , Abriouel-Hayani H. , Hita-Contreras F. 
Published: February 2024

Abstract
Exercise induces many health benefits, preventing or treating diseases. On the other hand, the intestine houses trillions of microbes with the ability to influence the normal physiology of the organism. The intestinal microbiota is immensely diverse, varies between individuals, and can fluctuate according to various factors, including physical activity. In this sense, the aim of this systematic review is to search through the recent knowledge, in order to elucidate the roles played by different exercise modalities on modulation of the intestinal microbiota of adults. A literature search was performed in the PubMed, SCOPUS and Web of Science databases. The main inclusion criteria were randomised controlled trials involving exercise and microbiota in adults. The initial search identified 1,103 publications of which 13 were finally included. The heterogeneity of the training parameters used in the studies, statistical analyses, and sequencing methods did not allow us to carry out a meta-analysis. However, the results tend to show that modulation of the gut microbiome is related to the type of exercise, the intensity and the time of intervention, where these changes are more significant at the level of specific microbial populations than richness and diversity indices.
Comparison of Proxy-Shortwave Cloud Albedo from SBUV Observations with CMIP6 Models
Authors: Weaver Clark , Wu Dong L. , Bhartia P. K. , Labow Gordon , Haffner David P. , Borgia Lauren , McBride Laura , Salawitch Ross 
Published: February 2024

Abstract
We construct a long-term record of top of atmosphere (TOA) shortwave (SW) albedo of clouds and aerosols from 340-nm radiances observed by NASA and NOAA satellite instruments from 1980 to 2013. We compare our SW cloud+aerosol albedo with simulated cloud albedo from both AMIP and historical CMIP6 simulations from 47 climate models. While most historical runs did not simulate our observed spatial pattern of the trends in albedo over the Pacific Ocean, four models qualitatively simulate our observed patterns. Those historical models and the AMIP models collectively estimate an equilibrium climate sensitivity (ECS) of ∼3.5°C, with an uncertainty from 2.7° to 5.1°C. Our ECS estimates are sensitive to the instrument calibration, which drives the wide range in ECS uncertainty. We use instrument calibrations that assume a neutral change in reflectivity over the Antarctic ice sheet. Our observations show increasing cloudiness over the eastern equatorial Pacific and off the coast of Peru as well as neutral cloud trends off the coast of Namibia and California. To produce our SW cloud+aerosol albedo, we first retrieve a black-sky cloud albedo (BCA) and empirically correct the sampling bias from diurnal variations. Then, we estimate the broadband proxy albedo using multiple nonlinear regression along with several years of CERES cloud albedo to obtain the regression coefficients. We validate our product against CERES data from the years not used in the regression. Zonal mean trends of our SW cloud+aerosol albedo show reasonable agreement with CERES as well as the Pathfinder Atmospheres–Extended (PATMOS-x) observational dataset.

Significance Statement
Equilibrium climate sensitivity is a measure of the rise in global temperature over hundreds of years after a doubling of atmospheric CO2 concentration. Current state-of-the-art climate models forecast a wide range of equilibrium climate sensitivities (1.5°–6°C), due mainly to how clouds, aerosols, and sea surface temperatures are simulated within these models. Using data from NASA and NOAA satellite instruments from 1980 to 2013, we first construct a dataset that describes how much sunlight has been reflected by clouds over the 34 years and then we compare this data record to output from 47 climate models. Based on these comparisons, we conclude the best estimate of equilibrium climate sensitivity is about 3.5°C, with an uncertainty range of 2.7°–5.1°C.
Estimation of Surface Sensible Heat Flux due to Precipitation over CONUS and Its Impact on Urban Extreme Precipitation Modeling
Authors: Tan Haochen , Kotamarthi Rao , Ray Pallav 
Published: February 2024

Abstract
The surface sensible heat flux induced by precipitation (QP) is a consequence of the temperature difference between the surface and the rain droplets. Despite its seemingly negligible nature, QP is frequently omitted from both meteorological and climatological models. Nevertheless, it is important to acknowledge the numerous occasions in which the instantaneous values of QP can be significant, particularly during extreme precipitation events. This study undertakes a comprehensive assessment of QP across the contiguous United States (CONUS) utilizing high-resolution reanalysis, observational data, and numerical modeling to examine the influence of QP on precipitation and the surface energy budget. The findings indicate that the spatial distribution of QP climatology is analogous to that of precipitation, with magnitudes ranging from 2 to 3 W m−2 predominantly over the Midwest and Southeast regions. A seasonal analysis of QP reveals that the highest values occurring during the June–August (JJA) period, averaging 3.18 W m−2. Peak QP values of approximately 4 W m−2 are observed during JJA over the Great Plains region. We hypothesize that the QP during an extreme precipitation event would be nonnegligible and have a significant impact on the local weather. To test this conjecture, we perform high-resolution simulations with and without QP during an extreme precipitation event over the Chicago Metropolitan Area (CMA). The results show that the QP may be a dominant factor compared to other components of surface heat flux during the zenith of precipitation hours. Also, QP has the potential to not only diminish precipitation but also alter and reconfigure the remaining surface energy budget components.
Mental health service utilization and help seeking behaviours of adult Cambodians living in Western countries: A systematic scoping review
Authors: Than Vannaral , Doroud Nastaran , O’Brien Lisa 
Published: February 2024

Background: Health disparity and under-utilization of health services is prevalent among Asian refugees and migrants in Western countries and can profoundly impact health outcomes. Cambodians who survived extreme physical and emotional trauma during the genocides enacted by the Khmer Rouge regime in the 1970’s are particularly vulnerable to poor mental health outcomes decades later. Understanding the experiences of help-seeking and service use by displaced Cambodians in Western countries may help to design more effective and culturally safe healthcare services. Aims: To identify characteristics or factors associated with help seeking behaviours and service utilization of displaced Cambodians with mental health issues living in Western countries. Methods: This review followed the Arksey & O’Malley methodological framework for scoping reviews. Articles for review were identified through searches of nine electronic databases and manual searches. Relevant articles were selected, and data was extracted and synthesized into key themes. Results: This review included 15 articles. Most of the studies were conducted in the USA ( n = 13) with one each conducted in Canada and New Zealand. Seven studies used qualitative interviews, five used a cross-sectional survey approach, two used a mixed-methods approach and one was a narrative review and case series. Key findings highlighted the impact of Cambodian cultural beliefs about mental health (guilt, shame and help-seeking stigma) on service utilization and the disconnect between Western models of service provision and preferred Cambodian ways of receiving support. Conclusion: Mental health services in Western countries are likely to be under-utilized by Cambodians due to a mismatch between health beliefs and Western models of care. Further investigation of the association between health beliefs and barriers to service utilization among adult Cambodian refugees is warranted.
Platelet-Rich Plasma Versus Alternative Injections for Osteoarthritis of the Knee: A Systematic Review and Statistical Fragility Index–Based Meta-analysis of Randomized Controlled Trials
Authors: Oeding Jacob F. , Varady Nathan H. , Fearington Forrest W. , Pareek Ayoosh , Strickland Sabrina M. , Nwachukwu Benedict U. , Camp Christopher L. , Krych Aaron J. 
Published: February 2024

Background: Based in part on the results of randomized controlled trials (RCTs) that suggest a beneficial effect over alternative treatment options, the use of platelet-rich plasma (PRP) for the management of knee osteoarthritis (OA) is widespread and increasing. However, the extent to which these studies are vulnerable to slight variations in the outcomes of patients remains unknown. Purpose: To evaluate the statistical fragility of conclusions from RCTs that reported outcomes of patients with knee OA who were treated with PRP versus alternative nonoperative management strategies. Study Design: Systematic review and meta-analysis; Level of evidence, 2. Methods: All RCTs comparing PRP with alternative nonoperative treatment options for knee OA were identified. The fragility index (FI) and reverse FI were applied to assess the robustness of conclusions regarding the efficacy of PRP for knee OA. Meta-analyses were performed to determine the minimum number of patients from ≥1 trials included in the meta-analysis for which a modification on the event status would change the statistical significance of the pooled treatment effect. Results: In total, this analysis included outcomes from 1993 patients with a mean ± SD age of 58.0 ± 3.8 years. The mean number of events required to reverse significance of individual RCTs (FI) was 4.57 ± 5.85. Based on random-effects meta-analyses, PRP demonstrated a significantly higher rate of successful outcomes when compared with hyaluronic acid ( P = .002; odds ratio [OR], 2.19; 95% CI, 1.33-3.62), as well as higher rates of patient-reported symptom relief ( P = .019; OR, 1.55; 95% CI, 1.07-2.24), not requiring a reintervention after the initial injection treatment ( P = .002; OR, 2.17; 95% CI, 1.33-3.53), and achieving the minimal clinically important difference (MCID) for pain improvement ( P = .007; OR, 6.19; 95% CI, 1.63-23.42) when compared with all alternative nonoperative treatments. Overall, the mean number of events per meta-analysis required to change the statistical significance of the pooled treatment effect was 8.67 ± 4.50. Conclusion: Conclusions drawn from individual RCTs evaluating PRP for knee OA demonstrated slight robustness. On meta-analysis, PRP demonstrated a significant advantage over hyaluronic acid as well as improved symptom relief, lower rates of reintervention, and more frequent achievement of the MCID for pain improvement when compared with alternative nonoperative treatment options. Statistically significant pooled treatment effects evaluating PRP for knee OA are more robust than approximately half of all comparable meta-analyses in medicine and health care. Future RCTs and meta-analyses should consider reporting FIs and fragility quotients to facilitate interpretation of results in their proper context.
Hepatic P53 upregulation and the genotoxic potential of acesulfame-K treatment in rats with a special emphasis on in vitro lymphocyte and macrophage activity testing
Authors: Mohammed Faten F. , Abdelrazik Eman G. , Anwar Abeer , Abdelgayed Sherein S. 
Published: February 2024

Acesulfame-k (Ace-k) is a widely used artificial sweetener in various products, and long-term cumulative and multisource exposure is possible despite inadequate toxicological data confirming its safety. Ninety male rats were divided into two main groups according to their body weight into immature and mature rats. Each group was subdivided into 3 subgroups: control untreated, 30 and 90 mg/kg b. w of Ace-k via gastric intubation. The treatment was performed daily 5 days per week for 12 weeks. At the end of the experimental period, blood samples were collected for in vitro testing of lymphocyte proliferation rate, comet assay, and macrophage activity about nitric oxide (NO) production. In addition, the collection of liver specimens was performed for P53 gene expression and histopathological evaluation. The results revealed that Ace-k induced modulation in lymphocyte proliferation rate and affected the production of NO by macrophages while increasing in tail moment in a dose-dependent manner that varied among different age groups. The upregulation of P53 in the liver was correlated with increased polyploidization and necro apoptotic reaction and various histopathological hepatic alterations. The present data revealed that chronic treatment of rats with Ace-k affects lymphocyte proliferation and macrophage activity in a dose-dependent manner. In addition, the genotoxic and hepatotoxic potential of Ace-k were confirmed.
Openness to Experience and Player Satisfaction in a Simulation Game
Authors: Dumblekar Vinod , Antony Suresh Paul , Dhar Upinder 
Published: February 2024

Background Openness to experience (OTE) is one of the Big Five traits that describe the personality of the individual. Player satisfaction (Satisfaction) is composed of the factors of excitement, challenge, learning experience, team victory and self-discovery in a simulation game. OTE and Satisfaction appear to have a symbiotic relationship that feeds on their characteristics and outcomes. This study is undertaken to understand the relationship between OTE and Satisfaction in a simulation game. Objectives of the Study The objectives are to develop a scale of OTE in the context of a simulation game, to identify the factors of OTE and to study the interactive effects of OTE and Satisfaction and their factors. Methods An instrument of 40 statements was administered to 190 post-graduate management students at the end of a brand-related simulation game. It had 12 statements that represented OTE and 28 statements of the Satisfaction scale. The data was purified and processed for factor analysis; the variables and their factors were subjected to correlation and regression. Results Two OTE factors, each of eigenvalue greater than one, were extracted and named search for novelty and passion to know. Discussion The conclusions of this study may be generalisable only to sample profiles that are most similar to the study sample, but not to other contexts due to the ambiguous effect of personality, contexts and cultures on the study variables. The strong positive correlations between OTE, Satisfaction and their factors show their bases in a common platform, i.e. the experience of the simulation game. The search for novelty predicts Satisfaction more powerfully than OTE predicts Satisfaction. Self-discovery, learning experience and excitement affect OTE positively and more powerfully than challenge, team victory or Satisfaction. Further studies of passion, intrinsic motivation and self-efficacy may enhance our understanding of their impact on Satisfaction.
Association Between Weightbearing CT and MRI Findings in Progressive Collapsing Foot Deformity
Authors: Andres Lynn , Donners Ricardo , Harder Dorothee , Burssens Arne , Nüesch Corina , Krähenbühl Nicola 
Published: February 2024

Background: Weightbearing computed tomography (WBCT) scans allow for a better understanding of foot alignment in patients suffering from progressive collapsing foot deformity (PCFD). However, soft tissue integrity (eg, spring ligament complex or tibialis posterior tendon) cannot be easily assessed via WBCT. As performing both WBCT and magnetic resonance imaging (MRI) might not be cost effective, we aimed to assess whether there is an association between osseous and soft tissue findings in WBCT and MRI. Methods: In this observational study, a consecutive cohort of 24 patients of various stages of PCFD (mean age 51 ± 18 years) underwent WBCT scans and MRI. Twenty-four healthy individuals of similar age, body mass index (BMI), and sex with WBCT scans were used as a control group. In addition to of osseous sinus tarsi impingement, 4 commonly used 3-dimensional (3D) measurements (talocalcaneal overlap [TCO], talonavicular coverage [TNC], Meary angle [MA], axial/lateral) were obtained using a dedicated postprocessing software (DISIOR 2.1, Finland) on the WBCT data sets. Sinus tarsi obliteration, spring ligament complex, tibiospring ligament integrity, as well as tibialis posterior tendon degeneration were evaluated with MRI. Statistical analysis was performed for significant ( P < .05) correlation between findings. Results: None of the assessed 3D measurements correlated with either spring ligament complex or tibiospring ligament tears. BMI and TCO were found to be associated with tibialis posterior tendon tears. Seventy-five percent of patients with osseous sinus tarsi impingement on WBCT also showed signs of sinus tarsi obliteration on MRI. Conclusion: Although WBCT reflects foot alignment and can reveal osseous sinus tarsi impingement in PCFD patients, the association between WBCT-based 3D measurements and ligament or tendon tears assessed via MRI is limited. WBCT appears complimentary to MRI regarding its diagnostic value. Both imaging options add important information and may impact decision making in the treatment of PCFD patients. Level of Evidence: Level IV, observational study.
Epidemiology of Breast, Corpus Uteri, and Ovarian Cancers in Lebanon With Emphasis on Breast Cancer Incidence Trends and Risk Factors Compared to Regional and Global Rates
Authors: Lakkis Najla A. , Abdallah Reem M. , Musharrafieh Umayya M. , Issa Hanane G. , Osman Mona H. 
Published: February 2024

Objectives This study explores the incidence and trends of breast (Bca), corpus uteri (CUca), and ovarian (Oca) cancer in Lebanon, a Middle Eastern country. It compares the Bca rates to regional and global ones and discusses Bca risk factors in Lebanon. Introduction Globally, Bca is the premier cause of cancer morbidity and mortality in women. Methods Data on female Bca, CUca, and Oca published by the Lebanese national cancer registry were obtained (ie, for the years of 2005 to 2016). The age-standardized incidence rates (ASIRw) and age-specific rates per 100,000 female population were computed. Results From 2005 to 2016, Bca, Oca, and CUca ranked first, sixth, and seventh, respectively, for cancer incidence among women in Lebanon. Bca alone accounted for 39.4% of all new female cancer cases. The ASIRw increased significantly for Bca and CUca (APC: 3.60 and 3.73, P < .05) but not for Oca (APC: 1.27, P > .05). The Bca ASIRw (per 100,000) increased significantly from 71.0 in 2005 to 115.6 in 2013 ( P < .05), then decreased steadily but non-significantly to reach 96.8 in 2016 ( P > .05). Lebanon’s Bca ASIRw is comparable to developed countries. This may reflect altered sociological and reproductive patterns as the country transitions from regional to global trends. The five-year age-specific rates analysis revealed that Bca rates rose steeply from 35-39 to 50-54, dropped slightly between 55 and 64, then rose till 75+. The five-year age-specific rates between 35 and 54 among Lebanese women were amongst the highest worldwide from 2008 to 2012, even higher than the rates in Belgium, which had the highest ASIRw of Bca worldwide in 2020. Conclusion Lebanon’s Bca ASIRw is among the highest globally. It’s important to investigate the contributing factors and develop a national Bca control strategy. This study supports the national recommendation in initiating Bca screening at age 40 for women.
Long-Term results of macular buckle for MTM stage 3-4 With maculoschisis and macular detachment without and With lamellar macular hole
Authors: Ripa Matteo , Motta Lorenzo , Matello Veronika , Frisina Rino , Parolini Barbara 
Published: February 2024

Purpose To report the long-term anatomical and functional results of macular buckle for Myopic Traction Maculopathy (MTM) in stages 3a, 3b, 4a, and 4b according to the MTM Staging System (MSS). Methods Retrospective observational cohort study involving 55 consecutive patients with MTM in stages 3a, 3b, 4a, and 4b who underwent macular buckle (MB). Postoperative outcomes, including optical coherence tomography (OCT) scans to evaluate the MTM stage and its progression, were evaluated 1-month postoperatively (i.e., “intermediate follow-up”) and at last follow-up ranging between 6 and 156 months postoperatively (i.e., “final follow-up”). Results Fifty-five eyes affected by MTM who underwent MB were enrolled. The mean preoperative and postoperative axial length was 31.13 ± 2.14 and 29.73 ± 2.16 mm, respectively (p < 0.01), with a mean axial shift of 1.32 ± 0.77 mm. The mean sample best corrected visual acuity (BCVA) at baseline, intermediate, and final follow-ups was 0.87 ± 0.36, 0.73 ± 0.31, 0.41 ± 0.32 logMar, respectively (p < 0.01). Foveal and retinal anatomical improvements were achieved in 50 (91%) and 53 (96.4%) eyes at intermediate follow-up, respectively. In the final follow-up, 54 (98.2%) and 55 (100%) eyes showed foveal and retinal anatomical improvements, respectively. Conclusions MB as a single procedure, when applied to MTM in stages 3a, 3b, 4a, and 4b, leads to significant anatomical and functional improvement. The MTM Staging System allows us to evaluate the best surgical technique and the surgical timing tailored to the different stages to increase the surgery's success and lower the complications of each technique.