bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidência e Prevalência da Sífilis Congênita: Uma Análise Epidemiológica Comparativa entre as Regiões Norte e Sudeste do Brasil (2019-2023)
Authors: De Miranda Franco Costa Giovana , De Jesus Santos João Victor , Sousa Soares Maria Eduarda , Brissi Benito da Silva Samara , Carlos de Queiroz Johny 
Published: April 2024

Este estudo visa preencher a lacuna na pesquisa brasileira sobre a incidência comparativa da sífilis congênita entre as regiões Sudeste e Norte. Pretende-se analisar quantitativamente a incidência da doença de 2019 a 2023 e descrever qualitativamente os fatores associados. Serão coletados dados sobre mães de crianças com sífilis congênita, como escolaridade, realização do pré-natal e idade materna, para uma análise abrangente. Trata-se de um estudo ecológico, observacional e temporal abrangendo a sífilis congênita nas regiões Norte e Sudeste do Brasil de 2019 a 2023. Os dados foram coletados do DATASUS em março de 2024. Serão realizadas análises quantitativas e qualitativas dos dados epidemiológicos e socioeconômicos.
Os casos de sífilis congênita nas regiões Norte e Sudeste, entre 2019 a 2023, revelaram uma redução significativa em ambas regiões. A distribuição dos casos variou conforme a escolaridade materna, com predominância de mães com ensino fundamental incompleto no Norte e de mães com ensino médio completo no Sudeste. Além disso, mostrou-se que, na região Norte, assim como na região Sudeste, um menor das mães não havia realizado o pré-natal. A faixa etária com a maioria dos casos foi entre 20 a 24 anos em ambas as regiões. Por fim, destacamos as diferenças expressivas em termos de densidade populacional entre as duas regiões do país, a fim de possibilitar uma análise mais objetiva.
Em resumo, a análise dos casos de sífilis congênita nas regiões Norte e Sudeste do Brasil destaca a necessidade de uma abordagem abrangente para lidar com o problema de saúde pública. A associação com a escolaridade materna e a realização do pré-natal ressalta a importância de estratégias preventivas amplas. É essencial uma abordagem coordenada entre diversos setores da sociedade para reduzir a incidência e prevalência da doença. Apesar das limitações do estudo, suas descobertas oferecem uma base sólida para orientar políticas de saúde e programas de prevenção.
Effect of Tensing Toe Relaxation Technique on Test Anxiety among B.Sc Nursing 1st Year Students in Selected Colleges, Bhubaneswar, Odisha
Authors: Soubhagya Ranjan Khilar  , Sivasankari Varadharasu  , Sanjukta Dixit  , Reena Singh  
Published: April 2024

Background: Test anxiety is a psychological condition that causes extreme stress and anxiety in exam situations. Students feel stress and anxiety before exams. It can disrupt their learning and lead to poor performance. Relaxation techniques, like tensing toe relaxation, are the most effective non-pharmacological techniques for reducing stress because they affect mental and physical states like depression, mood, anxiety, and self-blaming.Objective: To evaluate the effect of the tensing toe relaxation technique on test anxiety among first-year B.S.nursing students and the association of the level of test anxiety with their selected demographic variables.Methods: The Quasi-experimental research study was conducted in two selected colleges in Bhubaneswar, Odisha, among B. Sc. Nursing 1st year students. Thirty-four (34) students were selected for each Experimental and Control group by using the Purposive sampling technique. Nist, Diehl A test anxiety scale and a self-structured socio-demographic tool were used for collecting the data through the questioning method. After demonstrating the tensing toe relaxation technique to the experimental group, they were asked to practice for 2 weeks. The post- test was conducted at the end of two weeks.Results: Study findings show a reduction of test anxiety with (t = 6.02) (p = 0.000), which is highly significant at p 0.001, and also the unpaired t-test post-test values show a significant change at p 0.001. Furthermore, there is a significant association between the level of test anxiety and selected demographic variables at p <0.05.Conclusion: The Tensing toe relaxation technique is an effective intervention to reduce test anxiety.
Cross-language Exploration: a way to explore the use of L1 in the classroom at a Southeastern Mexican University
Authors: Arias de la Cruz Andrés , Morales Vázquez Eleazar , Arias Ovando Julio César , Silván Almeida Rolando Guadalupe 
Published: April 2024

The place of the First Language (L1), in the classroom has been studied by many researchers in relation to the advantages and disadvantages of the use of the mother tongue in foreign language (FL) courses. This study aimed at uncovering the main reasons for which participants use the L1, in this case Spanish in an EFL course and finding out students’ perceptions of the use of their L1 in an EFL course. This study was carried out at a Mexican undergraduate programme. Participants were 11 students who were enrolled in a basic English course from a business and economics undergraduate programmes during the first semester of 2019. The study used a qualitative method and followed an action research design. Data were collected through observation in situ, a questionnaire and a cross-language exploration assessment task. Findings reveal that the participants have a great acceptance of the Spanish use in the English class. Most of the participants agreed that they use Spanish for different reasons: to translate vocabulary, to socialize, to ask questions, to participate, to compare answers or vocabulary, and to compare similarities and differences between L1 and EFL. All in all, the use of the Spanish is something that is always present in language courses. Despite the generalized idea of it causing detrimental effects on the target language learning; this study showed that it can render positive effects, at least at early stages of the EFL learning process.
The Weakness of Soft X-Ray Intensity: Possible Physical Reason for Weak-line Quasars
Authors: Wu Jiancheng , Wu Qingwen , Jin Chichuan , Wu Jianfeng , Lei Weihua , Cao Xinwu , Fan Xiao , Lei Xiangli , Wang Mengye , Xue Hanrui , Lyu Bing 
Published: April 2024

Abstract
Weak-line quasars (WLQs) are a notable group of active galactic nuclei (AGNs) that show unusually weak UV lines even though their optical-UV continuum shapes are similar to those of typical quasars. The physical mechanism for WLQs is an unsolved puzzle in the AGN unified model. We explore the properties of UV emission lines by performing extensive photoionization calculations based on Cloudy simulations with different spectral energy distributions (SEDs) of AGNs. The AGN continua are built from several observational empirical correlations, where the blackbody emission from the cold disk, the power-law emission from the hot corona, and a soft X-ray excess component are considered. We find that the equivalent width (EW) of C iv from our models is systematically lower than observational values if the component of soft X-ray excess is neglected. The EW will increase several times and is roughly consistent with the observations after considering the soft X-ray excess component as constrained from normal type I AGNs. We find that the UV lines are weak for QSOs with quite large black hole mass (e.g., M
BH > 109
M
⊙) and weak soft X-ray emission due to the deficit of ionizing photons. As an example, we present the strength of C iv based on the multiband SEDs for three nearby weak-line AGNs, where the weaker soft X-ray emission normally predicts the weaker lines.
Multiple Patchy Cloud Layers in the Planetary-mass Object SIMP 0136+0933
Authors: McCarthy Allison M. , Muirhead Philip S. , Tamburo Patrick , Vos Johanna M. , Morley Caroline V. , Faherty Jacqueline , Bardalez Gagliuffi Daniella C. , Agol Eric , Theissen Christopher 
Published: April 2024

Abstract
Multiwavelength photometry of brown dwarfs and planetary-mass objects provides insight into their atmospheres and cloud layers. We present near-simultaneous J- and K

s
-band multiwavelength observations of the highly variable T2.5 planetary-mass object, SIMP J013656.5+093347. We reanalyze observations acquired over a single night in 2015 using a recently developed data reduction pipeline. For the first time, we detect a phase shift between J- and K

s
-band light curves, which we measure to be

39

.°

9

−
1.1

+
3.6

. Previously, phase shifts between near-infrared and mid-infrared observations of this object were detected and attributed to probing different depths of the atmosphere, and thus different cloud layers. Using the Sonora Bobcat models, we expand on this idea to show that at least two different patchy cloud layers must be present to explain the measured phase shift. Our results are generally consistent with recent atmospheric retrievals of this object and other similar L/T transition objects.
The Impact of Ambipolar Diffusion on the Rossby Wave Instability in a Protoplanetary Disk
Authors: Gholipour Mahmoud 
Published: April 2024

Abstract
Recent observational and simulation studies have revealed that ambipolar diffusion is an important phenomenon in the outer regions of a protoplanetary disk (PPD). However, numerous simulation studies have found that ambipolar diffusion suppresses the turbulence caused by the magnetorotational instability (MRI) in these regions of a PPD. The aim of this study is to investigate the impact of ambipolar diffusion on the Rossby wave instability (RWI) at large radii of a PPD. To accomplish this, we examine the occurrence of the RWI in a PPD threaded by the magnetic field in the presence of ambipolar diffusion. Additionally, we scale the ambipolar diffusivity with respect to both the toroidal magnetic field and an important parameter known as the Elsässer number. We obtain the growth rate of unstable RWI modes in the outer regions of a PPD using linear perturbation analysis. In our nonaxisymmetric perturbation analysis, we find that the amplitude of the toroidal field oscillates in various modes for small values of the Elsässer numbers. For small Elsässer numbers, the growth rate of unstable modes associated with the RWI decreases. In other words, ambipolar diffusion suppresses the perturbation caused by the RWI. This effect is similar to the effect of ambipolar diffusion on the MRI. In contrast to the MRI, where there is a range around 1 for the Elsässer numbers, the existence of ambipolar diffusion supports the occurrence of RWI. Finally, we compare our findings with those of simulation studies to emphasize the importance of RWI in the outer regions of a PPD.
Signal transduction in wound healing: The effects of plant-derived biologically active substances
Authors: Esad Merlin , Popova Mihaela , Apostolova Elisaveta , Bivolarska Anelia 
Published: April 2024

Wounds are among the most common skin diseases. They are formed after tissue injury and result in severe damage to the epidermis. The application of plants for wound healing is not only a cheap and accessible way of treatment, but also provides a reliable natural resource of medicinal substances with fewer side effects. Biologically active substances such as alkaloids, essential oils, flavonoids, tannins and phenolic compounds demonstrate a wide spectrum of action: wound healing, anti-inflammatory, antibacterial and antioxidant effects.
This review article examines the chemical composition of three plants - Calendula officinalis, Marrubium vulgare, Vitis vinifera and the signal transduction in skin wound healing. Studies have shown that they have a strong antioxidant effect, hemostatic activity, powerful vasoconstrictor effect, pro-angiogenic and cell-protective effects.
Because of the mentioned benefits of these plants, more scientific research and well-designed clinical trials are needed to establish their wider use in wound treating medicaments.
Ransomware : le dossier comprendre l’ennemi
Authors: Fronczak Stéphane 
Published: April 2024

Il était une fois un bandit de grand chemin nommé Ransomware … Voilà qui pourrait débuter la narration qui va suivre concernant ce malandrin, un brigand des Temps modernes. S’il n’est plus question des guerres qui ont opposé si longtemps la France à l’Angleterre, l’analogie avec les cybercriminels n’est pas si éloignée de cela. Sans doute cela est-il dû au fait qu’il s’agisse d’attaques perpétrées par des bandes d’assaillants ayant pour unique objectif la remise de fonds, l’obtention d’un butin, et ce, sur les chemins que sont nos autoroutes de l’information, nos réseaux sociaux, nos routes d’échanges numériques. L’actualité SI & IT, cyber et criminelle fait la part belle depuis plusieurs années à ce phénomène. Le rançongiciel ne distingue pas ses victimes (quelques exceptions dernièrement) mais s’affranchit de toutes frontières, règles, lois, pour n’user que de celles lui permettant d’atteindre son objectif. Car ne perdons pas de vue que les auteurs d’attaques par rançongiciels poursuivent des objectifs liés à la déstabilisation et à la terreur au sein d’une entreprise ou chez un particulier.
Conformité et sécurité : un cran au-dessus ?
Authors: Coupez François 
Published: April 2024

Ayant pendant longtemps suivi des chemins parallèles, sécurité des systèmes d’information et conformité, notamment en matière de protection des données, sont deux concepts qui sont aujourd’hui fortement liés, que ce soit par la réglementation ou les régulateurs. La sécurité des systèmes d’information faisant régulièrement la une des journaux, la « culture sécurité » infusant dans tous les secteurs économiques, les régulateurs ont changé de vision et intègrent cet élément de façon cruciale dans leurs audits des entreprises dont ils ont la supervision. Pour la CNIL par exemple, la sécurité est un angle d’audit d’autant plus important que plusieurs facteurs se coagulent : l’afflux d’anciens de l’ANSSI dans ses rangs a accru sa compétence, le RGPD s’inscrit dans la droite ligne de la loi du 6 janvier 1978 et se fonde peu ou prou sur la sécurisation des systèmes d’information, la protection des données ne peut être assurée que si la sécurité des systèmes d’information et des infrastructures est elle-même renforcée, etc.
Apocalypse JO
Authors: Perelman Marc 
Published: April 2024

Malgré une propagande sans relâche pour aller chercher l’adhésion aux jo de Paris 2024, les Français regardent ailleurs. Ils observent avec inquiétude les conflits en Ukraine, en Israël, les tensions entre la Chine et Taïwan et les deux Corées, qui rendent paradoxaux des jo se déroulant sous l’étendard des trois principales valeurs de l’olympisme : l’« excellence », l’« amitié » et le « respect ». Tandis que le cio a finalement décidé d’accepter la participation de quelques athlètes russes et biélorusses sous bannière neutre, la question du boycott reste posée par l’Ukraine. Et sauf décision tardive, la Seine sera transformée en scène d’un spectacle kitsch aussi monumental que dangereux et désuet .
Paris 2024 : récit d’une candidature
Authors: Morteau Alexandre 
Published: April 2024

Après l’échec de Paris 2012, les décideurs politiques, administratifs et sportifs identifient un « problème » des candidatures olympiques françaises. Ils établissent un cadre d’action commun et une mise en administration des grands événements sportifs internationaux pour produire un environnement institutionnel et des réseaux propices à la construction d’une nouvelle candidature. Une fois celle de Paris 2024 officiellement lancée, le travail de ces entrepreneurs de l’olympisme consiste à éviter une politisation qui mettrait en péril le projet .
Visual Quality Assessment After FS-LASIK Using Customized Aspheric Ablation Profile for Age-Related Accommodation Deficiency Compensation
Authors: Zhang Ruiyu , Yuan Yifei , Zhang Yu , Chen Yueguo 
Published: April 2024

Purpose:
To evaluate clinical outcomes and visual quality 12 months after femtosecond laser–assisted laser in situ keratomileusis (FS-LASIK) performed with the Custom-Q algorithm for correction of myopia with or without astigmatism and compensate for age-related accommodation deficiency.

Methods:
Patients who had Custom-Q FS-LASIK for myopia and myopic astigmatism with age-related accommodation deficiency were included in this retrospective study. Distance, intermediate, and near visual acuities, objective and subjective refractions, Q-factor, corneal higher order aberrations (HOAs), accommodation function, defocus curve, contrast sensitivity, and a subjective questionnaire assessing visual quality were evaluated 12 months postoperatively.

Results:

Clinical data of 43 cases were analyzed. The mean age was 42.02 ± 1.85 years (range: 40 to 48 years). At the 12-month follow-up visit, there were 43 (100%), 42 (97%), and 33 (77%) patients who achieved a binocular uncorrected distance, intermediate, and near visual acuity, respectively, better than 20/20 separately. Defocus curves revealed better distance vision in the dominant eyes, and the nondominant eyes performed better at intermediate and near vergence (
P
< .001). The Q-value and corneal spherical aberration coefficient were more positive in the dominant eyes than those in the nondominant eyes (
P
< .001). The accommodative amplitude and relative accommodation improved binocularly (
P
< .001). The questionnaire demonstrated high patient satisfaction with near vision, and no one reported having severe visual disturbance.

Conclusions:
For myopic patients with age-related accommodation deficiency, the Custom-Q algorithm proved to be an effective way to achieve acceptable near vision without compromising distance vision.

[
J Refract Surg
. 2024;40(4):e245–e252.]
Human β-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long non-coding RNA TCONS_00014506
Authors: Zhao Yu-Xin , Cui Yan , Li Xin-Hong , Yang Wen-Hong , An Shi-Xiang , Cui Jia-Xian , Zhang Min-Yu , Lu Jing-Kun , Zhang Xuan , Wang Xiu-Mei , Bao Li-Li , Zhao Peng-Wei 
Published: April 2024

BACKGROUND
Colorectal cancer has a low 5-year survival rate and high mortality. Human β-defensin-1 (hBD-1) may play an integral function in the innate immune system, contributing to the recognition and destruction of cancer cells. Long non-coding RNAs (lncRNAs) are involved in the process of cell differentiation and growth.
AIM
To investigate the effect of hBD-1 on the mammalian target of rapamycin (mTOR) pathway and autophagy in human colon cancer SW620 cells.
METHODS
CCK8 assay was utilized for the detection of cell proliferation and determination of the optimal drug concentration. Colony formation assay was employed to assess the effect of hBD-1 on SW620 cell proliferation. Bioinformatics was used to screen potentially biologically significant lncRNAs related to the mTOR pathway. Additionally, p-mTOR (Ser2448), Beclin1, and LC3II/I expression levels in SW620 cells were assessed through Western blot analysis.
RESULTS
hBD-1 inhibited the proliferative ability of SW620 cells, as evidenced by the reduction in the colony formation capacity of SW620 cells upon exposure to hBD-1. hBD-1 decreased the expression of p-mTOR (Ser2448) protein and increased the expression of Beclin1 and LC3II/I protein. Furthermore, bioinformatics analysis identified seven lncRNAs (2 upregulated and 5 downregulated) related to the mTOR pathway. The lncRNA TCONS_00014506 was ultimately selected. Following the inhibition of the lncRNA TCONS_00014506, exposure to hBD-1 inhibited p-mTOR (Ser2448) and promoted Beclin1 and LC3II/I protein expression.
CONCLUSION
hBD-1 inhibits the mTOR pathway and promotes autophagy by upregulating the expression of the lncRNA TCONS_00014506 in SW620 cells.
Long noncoding RNAs HAND2-AS1 ultrasound microbubbles suppress hepatocellular carcinoma progression by regulating the miR-873-5p/tissue inhibitor of matrix metalloproteinase-2 axis
Authors: Zou Qiang , Wang Hao-Wen , Di Xi-Liang , Li Yuan , Gao Hui 
Published: April 2024

BACKGROUND
Increasing data indicated that long noncoding RNAs (lncRNAs) were directly or indirectly involved in the occurrence and development of tumors, including hepatocellular carcinoma (HCC). Recent studies had found that the expression of lncRNA HAND2-AS1 was downregulated in HCC tissues, but its role in HCC progression is unclear. Ultrasound targeted microbubble destruction mediated gene transfection is a new method to overexpress genes.
AIM
To study the role of ultrasound microbubbles (UTMBs) mediated HAND2-AS1 in the progression of HCC, in order to provide a new reference for the treatment of HCC.
METHODS
In vitro , we transfected HAND2-AS1 siRNA into HepG2 cells by UTMBs, and detected cell proliferation, apoptosis, invasion and epithelial-mesenchymal transition (EMT) by cell counting kit-8 assay, flow cytometry, Transwell invasion assay and Western blotting, respectively. In addition, we transfected miR-837-5p mimic into UTMBs treated cells and observed the changes of cell behavior. Next, the UTMBs treated HepG2 cells were transfected together with miR-837-5p mimic and tissue inhibitor of matrix metalloproteinase-2 (TIMP2) overexpression vector, and we detected cell proliferation, apoptosis, invasion and EMT. In vivo , we established a mouse model of subcutaneous transplantation of HepG2 cells and observed the effect of HAND2-AS1 silencing on tumor formation ability.
RESULTS
We found that UTMBs carrying HAND2-AS1 restricted cell proliferation, invasion, and EMT, encouraged apoptosis, and HAND2-AS1 silencing eliminated the effect of UTMBs. Additionally, miR-873-5p targets the gene HAND2-AS1, which also targets the 3’UTR of TIMP2. And miR-873-5p mimic counteracted the impact of HAND2-AS1. Further, miR-873-5p mimic solely or in combination with pcDNA-TIMP2 had been transformed into HepG2 cells exposed to UTMBs. We discovered that TIMP2 reversed the effect of miR-873-5p mimic caused by the blocked signalling cascade for matrix metalloproteinase (MMP) 2/MMP9. In vivo results showed that HAND2-AS1 silencing significantly inhibited tumor formation in mice.
CONCLUSION
LncRNA HAND2-AS1 promotes TIMP2 expression by targeting miR-873-5p to inhibit HepG2 cell growth and delay HCC progression.
Clinical pathological characteristics of “crawling-type” gastric adenocarcinoma cancer: A case report
Authors: Xu Yong-Wei , Song Yan , Tian Jun , Zhang Ba-Cui , Yang Yu-Sheng , Wang Jing 
Published: April 2024

BACKGROUND
Gastric cancer (GC) is a significant health problem worldwide, and early detection and accurate diagnosis are crucial for improving patient outcomes. Crawling-type gastric adenocarcinoma is a rare subtype of GC that has unique histopathological and clinical characteristics, and its diagnosis and management can be challenging. This pathological type of GC is also rare.
CASE SUMMARY
Here, we report the case of a patient who underwent ordinary endoscopy, narrow-band imaging, and endoscopic ultrasonography intending to determine the extent of tumor invasion and upper abdominal enhanced computed tomography and whether there was tumor metastasis. Then, endoscopic submucosal dissection was performed. After pathological and immunohistochemical examination, the pathological diagnosis was crawling-type gastric adenocarcinoma. This is a very rare and special pathological type of tumor. This case highlights the importance of using advanced endoscopic techniques and pathological examination in diagnosing and managing gastric crawling-type adenocarcinoma. Moreover, the findings underscore the need for continued research and clinical experience in this rare subtype of GC to improve patient outcomes.
CONCLUSION
The “crawling-type” GC is a rare and specific tumor pathology. It is difficult to identify and diagnose gliomas via endoscopy. The tumor is ill-defined, with a flat appearance and indistinct borders due to the lack of contrast against the background mucosa. Pathology revealed that the tumor cells were hand-like, so the patient has diagnosed with “crawling-type” gastric adenocarcinoma.