bluuebunny/crossref_metadata_2025_split huggingface dataset:
24-Year-Old Patient with Klippel-Trenaunay Syndrome Underwent Cementless Robotic Cruciate-Retaining TKA
Authors: Reading Landon , Brown Colin , Pasqualini Ignacio , Huffman Nickelas , Piuzzi Nicolas S. 
Published: April 2024

Case:
A 24-year-old man with Klippel-Trenaunay syndrome (KTS) presented with severe knee osteoarthritis unresponsive to conservative measures. Owing to end-stage, debilitating arthritic symptoms, surgery was pursued. Careful preoperative, multidisciplinary planning/treatment included magnetic resonance imaging to characterize the venous malformations throughout the right lower extremity, preoperative sclerotherapy, sirolimus, and robotic-assisted cementless total knee arthroplasty (TKA).

Conclusion:
Cementless robotic-assisted TKA with selective patellar resurfacing can be a viable option for young KTS patients with severe osteoarthritis when a meticulous multidisciplinary approach, including sclerotherapy and advanced imaging, is undertaken to analyze vascular abnormalities, minimize surgical risks, preserve bone stock, and optimize outcomes.
Exertional Lower Extremity Pain in a Triathlete Caused by External Iliac Artery Endofibrosis
Authors: Okamoto Yasufumi , Funasaki Hiroki , Tanaka Kota , Ohki Takao , Saito Mitsuru 
Published: April 2024

Case:
This report describes a 25-year-old female professional triathlete with right external iliac artery endofibrosis (EIAE) that was definitively diagnosed on contrast-enhanced magnetic resonance images obtained immediately after treadmill running. The EIAE was treated by percutaneous transluminal angioplasty. By 8 weeks after surgery, she had no symptoms of claudication or pain in the right thigh after a 1-hour running session. There has been no recurrence in 1 year postoperatively.

Conclusion:
EIAE is a rare condition and difficult to diagnose in a timely manner because symptoms and radiographic imaging features appear only during intense exercise. Our patient was successfully treated with percutaneous transluminal angioplasty.
Relación de la estrategia, estructura y cultura en la sostenibilidad de las Instituciones de Educación Superior (IES)
Authors: Mejía Zambrano Fabio , Fernando Reinoso Juan , Pinzón José Víctor 
Published: April 2024

El propósito del presente estudio es proporcionar un análisis de la información relacionada con las publicaciones de investigación científica asociadas a la gestión universitaria, y su relación con la estrategia, cultura y estructura, disponibles en Web of Science y Scopus. El estudio se desarrolló considerando la siguiente pregunta, ¿cómo se relaciona la estrategia, estructura y cultura en la sostenibilidad de las instituciones de educación superior? Con el fin de alcanzar el objetivo implícito en ella, se desarrolló un análisis bibliométrico a través del programa VOSviewer®. Se identificó los conceptos recurrentes que sirvieron de base para estructurar, a través de un análisis de contenido, la fundamentación teórica de las categorías fundantes que generan tensión en la formulación del problema. Posteriormente, se presenta la discusión que plantea la interacción de las categorías incluidas en la investigación. En el análisis realizado se hace alusión a cómo los elementos de gestión estratégica influyen en las dimensiones de la sostenibilidad, ahí se propone un aporte diferencial susceptible de ser aplicado en contexto, según la naturaleza y tipología en las IES, trascendiendo el alcance de la discusión teórica.
Se identificó que la estrategia, la estructura y la cultura son elementos transversales de una categoría emergente en el estudio denominada gobernanza, que está asociada a la gestión estratégica, a la plena autonomía universitaria, a los nuevos instrumentos de responsabilidad pública y al aseguramiento de la calidad. Se encontró que la gobernanza, es catalogada en la literatura reciente, como el factor determinante para la sostenibilidad de las IES.
Fluid Spontaneous Imbibition Under the Influence of Osmotic Pressure in Deep Coalbed Methane Reservoir in the Ordos Basin, China
Authors: Ma Ruying , Yao Yanbin , Zhang Xiaona , Dai Xuguang , Wang Zefan , Sun Xiaoxiao 
Published: April 2024

Summary
The flowback rate of a hydraulic fracturing fluid is related to coalbed methane (CBM) production in gas wells. The deep (&gt;2000 m) CBM reservoir in the Ordos Basin has an extremely high salinity (&gt;200 000 mg/L), which results in a very low flowback rate of fracturing fluid. The mechanism underlying the extremely low flowback rate of the fracturing fluid remains unclear. This study experimentally simulated two patterns of osmotic pressure variation that exist at a hydraulic fracturing site: the processes of injection of a low-salinity fracturing fluid into a high-salinity reservoir and a high-salinity fracturing fluid into a low-salinity reservoir. Low-field nuclear magnetic resonance (NMR) technology was used to monitor dynamic fluid migration and fluid distribution in the coals. Results showed that osmotic pressure is a driving force for spontaneous imbibition when the salinity of the fracturing fluid is lower than that of the reservoir water, and more fluid enters the coal as the osmotic pressure increases. This causes the displacement of the high-salinity fluid already present in the micropores by the low-salinity fracturing fluid. In high-salinity deep coal seams, both osmotic pressure and capillary forces cause the spontaneous imbibition of the fracturing fluid from fractures into pores, promoting CH4 desorption, alleviating the water-blocking effect, and enhancing the filtration loss of the fracturing fluid. In contrast, the injection of a high-salinity fluid into the reservoir with a low-salinity brine (LSB) creates an osmotic pressure difference that prevents fluid imbibition. In shallow, low-salinity coal seams, the injection of high-salinity fracturing fluids can result in high flowback rates. Therefore, these two injection schemes are significant for an understanding of the role of osmotic pressure in deep CBM extraction and serve as valuable guides for optimizing the selection of the fracturing fluid and improving its effective flowback.
WITHDRAWN: Four weeks minimalist shoe walking improves measures of foot posture and balance in healthy young adults – a randomized controlled trial
Authors: Gabriel Anna , Wearing Scott , Horstmann Thomas , Konrad Andreas 
Published: April 2024

Abstract
The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Effective optimization of atomic decoration in giant and superstructurally ordered crystals with machine learning
Authors: Cerasoli Frank , Donadio Davide 
Published: April 2024

Abstract
Crystals with complicated geometry are often observed with mixed chemical occupancy among Wyckoff sites, presenting a unique challenge for accurate atomic modeling. Similar systems possessing exact occupancy on all sites can exhibit superstructural ordering, dramatically inflating the unit cell size. Here, we propose a site permutation search (SPS) algorithm for discovering the optimal atomic decoration on fixed crystalline geometries. Our approach relies on the evidence that, for a given chemical composition, a crystal graph convolutional neural network estimates the correct energetic ordering of different atomic decorations, as predicted by electronic structure calculations. This provides a suitable energy landscape that can be optimized according to site occupation, allowing the prediction of chemical decoration in crystals exhibiting mixed or disordered occupancy, or superstructural ordering. The optimization algorithm is based on Monte Carlo moves combined with simulated annealing and basin-hopping techniques. Verification of the procedure is carried out on several known compounds, including the superstructurally ordered clathrate compound Rb8Ga27Sb16 and vacancy-ordered perovskite Cs2SnI6, neither of which were previously seen during the neural network training. Additionally, the critical temperature of an order-disorder phase transition in solid solution CuZn is probed with our SPS routines by sampling site configuration trajectories in the canonical ensemble. This strategy provides an accurate method for determining favorable decoration in complex crystals and analyzing site occupation at unprecedented speed and scale.
SMAC mimetics drive microglia phenotype and glioblastoma immune microenvironment
Authors: Snacel-Fazy Emmanuel , Soubéran Aurélie , Grange Magali , Joseph Kevin , Colin Carole , Morando Philippe , Luche Hervé , Brustlein Sophie , Debarbieux Franck , Siret Carole , de Pavert Serge A. van , Rougon Geneviève , Figarella-Branger Dominique , Ravi Vidhya Madapusi , Tabouret Emeline , Tchoghandjian Aurélie 
Published: April 2024

Abstract
Background Tumor-associated macrophages/microglia (TAMs) are highly plastic and heterogeneous immune cells that can be immune-supportive or tumor-supportive depending on the microenvironment. TAMs are the most abundant immune cells in glioblastoma (GB) and play a key role in immunosuppression. Therefore, TAMs reprogramming toward immune-supportive cells is a promising strategy to overcome treatment resistance. In this study, we investigated the effect of inhibiting the Inhibitor of Apoptosis proteins (IAPs) by SMAC mimetics (SM) on TAMs reprogramming.
Methods We used scRNAseq human GB databases to identify IAPs expression by TAMs. We treated explants and cultured immune cells isolated from human GB samples with SM to determine IAPs involvement in TAMs phenotypes and activities as evaluated by immunofluorescences, flow cytometry and cytokine array. We set up co-cultures of microglia and spheroids/tumoroids to determine the role of microglia in SM-response. Then we designed a relevant immunogenic mouse GB model to decipher the spatio-temporal densities, distribution, phenotypes and function of TAMs with or without SM treatment. We used light-sheet microscopy, two-photon imaging, a transgenic mouse with fluorescent TAM subsets and mass cytometry.
Results We showed that IAPs are expressed in TAMs. SM treatment promoted microglia pro-apoptotic and anti-tumoral function viacaspase-3 pro-inflammatory cleavage and the inhibition of tumoroids growth. In vivo, SM promoted microglia activation, antigen-presenting function and their tumor infiltration. In addition, we observed a remodeling of the blood vessels, a decrease in anti-inflammatory macrophages and an increased level of monocytes and their monocyte-derived dendritic cell progeny. This reprogramming of the TAM landscape was associated with an increase in CD8 T cell density and activation.
Conclusion Altogether, these results demonstrated that SM drive microglia toward an active phenotype with pro-apoptotic and anti-tumoral function and modify the GB immune landscape. This identifies SM as a molecule of choice for TAMs reprogramming.
An experimental study to determine the effects of particle size and bifurcation angle on the distribution of flow and sediment transport parameters in a bifurcated channel.
Authors: Das Amit , Barman Bibhas Chandra , Nandi Nityananda 
Published: April 2024

Abstract
Flow and sediment sharing in a bifurcated channel are considered to be a very important issues in river engineering and flood management. The present study has been conducted based on the field bifurcation of the Kangsabati river bifurcates at Kapastikri, about 75 km downstream of Kangsabati reservoir of West Midnapore, West Bengal, India. A scaled physical model simulating bifurcation region was conducted on a fixed-bed model at the Laboratory of River Research Institute (RRI), West Bengal (WB), India. The model set-up has been run with a range of discharges, including low, moderate, and high with three different sets of bifurcation angles. Furthermore, three different sizes of sediment of varying densities have been used to find the transport capacity of sediment for individual bifurcated angle. A set of data have been collected for different conditions like varying discharge, angle of bifurcation, mean size of sediment () particle and a comprehensive analysis have been done with respect to collected data to see how discharge and sediment load (bed-load) are distributed over the bifurcated branches. The present physical model study has determined the optimum discharge in the main channel for which the sediment and discharge get equally distributed over the bifurcated branches. The experimental data confirm that the distribution of bed load is dependent on the shape of the bifurcation and the sediment transport ratio (s1/s2) is sensitive to the angle of bifurcation in which s1 & s2 represent sediment transport rate (kg/hr) in respective branches.
Early detection of esophageal cancer using multi-institutional data: An evaluation of AI detection algorithms based on narrowband and white-light imaging data
Authors: Kim Kwang Gi , Baik YoungSeo , Lee Hannah , Kim YoungJae , Chung Jun-Won 
Published: April 2024

Abstract
Esophageal cancer is one of the most common cancers worldwide. In particular, esophageal squamous epithelial cell carcinoma is primarily diagnosed at the end stage and has a poor prognosis. For the early diagnosis and detection of esophageal cancer, this study aimed to develop an algorithm for detecting tumors in esophageal endoscopic images using innovative artificial intelligence (AI) technology. White-light images and narrowband image data collected at Gachon University Gil Hospital were used, and lesions were detected by applying the YOLOv5 and RetinaNet detection models. This study evaluated the performance of the model using precision, sensitivity, and the number of misdetections per image as evaluation indicators in a large-scale dataset. Additionally, the generalizability of the model was verified using external data collected from various institutions. The results showed that the AI model exhibited high precision and sensitivity in white-light and narrowband images by analyzing not only polyps but also superficial esophageal cancer, and the RetinaNet model exhibited excellent performance. These results are expected to contribute to a reduction in the misdiagnosis rate by enabling a more precise and rapid diagnosis. This study presents an effective method for detecting esophageal tumors through AI-based esophageal endoscopic image analysis, and it is expected to be helpful in investigating AI models that predict the depth of lesion invasion by incorporating real-time video-based detection and synthesis algorithms. These efforts are expected to contribute significantly to the effective diagnosis and treatment of esophageal cancer, thereby promoting the standardization of medical services.
Sun Path Analysis and Energy Optimization of a Gable Greenhouse for Production of Tomatoes
Authors: Ssenyimba Shaffic , Rwahwire Samson , Ildephonse Nibikora , Lwanyaga Joseph Ddumba , Kanyarusoke Kant , Musinguzi Wilson Babu 
Published: April 2024

Abstract

Uganda's rapid economic growth and rising quality of life have led to a significant increase in building energy consumption. This has led to a critical energy conservation challenge, especially in buildings. The country's scarcity of resources and high population growth have increased the need for sustainable energy sources. The paper examines the sun path, heating and cooling loads, optimal orientation, and solar radiation of a gable greenhouse at Busitema University, predicting it using Ecotect software and Solar Tool. A greenhouse energy optimization study was conducted using Ecotect 3D editor and Building Information Modeling (BIM), measuring solar radiation on each side of the structure. The design was optimized by analyzing solar radiation on warmest days and throughout the year, determining maximum loads, and estimating cumulative solar radiation for direct-gain passive solar heating. The optimal greenhouse orientation of 102.0 degrees was determined, resulting in maximum solar radiation of 0.04 kWh/m2 and a conceptual mass of 0.09 kWh/m2 and 0.002 kWh/m2, respectively. The conceptual mass utilized 127.55 kWh/m2 of annual solar energy, requiring 6.091 kWh of ventilation, energy and 23.072 kWh of solar radiation. HVAC, energy consumed was 110.543 kWh, with October requiring the most heating. Graphical representations of the sun's path and solar radiation forecasts help identify the ideal greenhouse orientation, evaluating radiation filtering, covering materials, and thermally resistant designs. This information is crucial for achieving indoor thermal comfort for the crops to be grown while reducing heat gain. The results of this study are beneficial for both conserving building energy and creating a comfortable environment for crops to grow in greenhouses in the future.
Non-Abelian dynamical gauge field and topological superfluids in optical Raman lattice
Authors: Liu Xiong-Jun , Zhou Xin-Chi , Yang Tian-Hua , Wang Zhi-Yuan 
Published: April 2024

Abstract
We propose a novel scheme to realize non-Abelian dynamical gauge field for ultracold fermions, and uncover a new pairing mechanism for topological superfluidity. The dynamical gauge fields arise from a nontrivial compensation effect between the large Zeeman detuning and strong Hubbard interaction in a two-dimensional (2D) optical Raman lattice. The spin-flip transitions are forbidden by the large Zeeman detuning, but restored when the Zeeman splitting is compensated by Hubbard interaction, generating a dynamical non-Abelian gauge field that leads to a correlated 2D spin-orbit interaction depending on local state configurations. The topological superfluid from a novel pairing driven by 2D dynamical gauge fields is reached with high feasibility, showing a broad phase region without competing orders at relevant fillings, and can be easily prepared in experiment. Our work can open up an avenue to emulate non-Abelian dynamical gauge fields and exotic correlated topological phases with feasibility and particularly, paves the way for realizing the non-Abelian topological superfluids.
The pharmacokinetics, pharmacodynamics and tolerability of SHR6508 in Chinese healthy subjects
Authors: ZHANG Shengting , TAN Hong-yi , YANG Shuang , YANG Xiao-yan , CUI Chang , HUANG Jie , YANG Guo-ping 
Published: April 2024

Abstract

Background
Secondary hyperparathyroidism (SHPT) mainly occurs in patients with chronic renal failure. SHR6508 is a new type of calcimimetic molecule, intended for patients with SHPT who are undergoing maintenance hemodialysis for chronic kidney disease. This study aimed to evaluate the pharmacokinetics (PK), pharmacodynamics (PD), safety, and tolerability of a new calcimimetic agent, SHR6508 injection, in healthy Chinese subjects.
Methods
In this phase I study, healthy subjects were administered SHR6508 injection via intravenous infusion according to a randomization table on the morning of the first day after admission. Blood samples were collected at 15 time points to measure the pharmacokinetic (PK) and pharmacodynamic (PD) parameters of SHR6508. Adverse events that occurred during administration were also evaluated.
Results
23 subjects were successfully screened and enrolled in the study. Except for 1 subject who withdrew from the study before medication, the remaining 22 subjects completed the study. No serious adverse events or adverse events leading to death occurred. The blood drug concentration of SHR6508 injection in healthy subjects reached its peak rapidly after a single intravenous dose. With the exception of the low-dose group, there was no significant difference in the distribution and elimination-related parameters Vz, t1/2z, and CLz between the other dose groups. The plasma drug exposure level (Cmax and AUC) of SHR6508 increased proportionally with the dose, and it showed linear pharmacokinetic characteristics within the dose range of 0.5-5 mg. The results of variance analysis showed no significant difference in PK characteristics between different genders.
Conclusion
After a single intravenous injection of 0.5-5 mg of SHR6508 injection in healthy subjects, the iPTH and blood calcium levels in the body decreased, and this effect showed dose-dependent characteristics, which is consistent with the expected effect of this product. The overall safety and tolerability of SHR6508 injection in healthy subjects after a single intravenous dose of 0.5-5 mg was good.
Trial Registration:
The trial is registered at chinadrugtrials.org.cn (ChiCTR2100048905)(19/07/2021).
What are the stumbling blocks to shared prosperity in China
Authors: Guo Jiahong , Yang Lidan , CAO Shixiong 
Published: April 2024

Abstract
Wealth inequality, which has caused repeated economic crises and led to regime change throughout history, continues to harm people around the world. The solution is to share prosperity, and this has become a political goal pursued by many governments. To find an effective way to achieve shared prosperity, we must recognize the causes of inequality between the rich and the poor so we can apply the right corrective measures. In the present study, we used the most recent available data for China to examine income inequality from three perspectives (the urban-rural gap, industrial gap, and regional disparities) to identify the underlying structural factors influencing economic inequality in China. We found that urbanization was a decisive factor in reducing the urban–rural income gap, but that it widened the industrial and regional income gaps. Transfer payments, social security, and agricultural mechanization all reduced income inequality, whereas basic and higher education had different effects for the three income gaps, and fiscal decentralization reduced the regional gap but widened the urban-rural and industrial gaps. In our study of regional differences, we found that structural factors in western China were the most responsive to income inequality. Thus, achieving urban-rural integration, improving agricultural mechanization, enhancing social security coverage, providing financial transfers to low-income enterprises, promoting regional equity in education, and improving local government assessment indicators will be the key to achieving shared prosperity. China's decision-making on the road to achieving shared prosperity will provide lessons for other developing countries.
A cognitive approach to better understand foraging strategies of the adult domestic hen
Authors: Degrande Rachel , Cornilleau Fabien , Jardat Plotine , Ferreira Vitor Hugo Bessa , Lansade Léa , Calandreau Ludovic 
Published: April 2024

Abstract

Foraging is known to be one of the most important activity in the behavioral budget of chickens. However, how these animals adapt different foraging strategies to diverse environmental variations is currently poorly understood. To gain further insight into this matter, in the present study, hens were submitted to a two tubes tasks. In this task, the experimenter can manipulate the information that enables the hens to find a food reward (visible or not), placed in one of two tubes. We first tested hens under free-choice conditions (no penalty for exhaustive searching in both tubes). Under these conditions, the hens adopted a non-random, side-biased strategy when the food location was not directly visible. Subsequently, a subgroup of hens was tested under forced-choice conditions (no food reward if the unbaited tube is visited first). This constraint increased the risk of the hen not receiving food. Under these conditions, when the location of the food was not directly visible, the hens learned to choose by exclusion. We conclude that hens can selectively adapt their foraging strategy to the point of adopting an exclusion performance, depending on available information and environmental constraints (high or low risk).