bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of intramural hematoma: a novel use of 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging
Authors: Yang Fan , Chen Yuanwei , Zhou Yongrong , Shao Dan , Luo Jianfang 
Published: March 2024

Abstract
Background
Aortic intramural hematoma (IMH) is one of the typical entities of acute aortic syndrome and probably accounts for 5–25% of all cases. The ulcer-like projections (ULP), which are described as a focal, blood-filled pouch protruding into the hematoma of the aortic wall, are regarded as one of the high-risk imaging features of IMH and may cause initial medical treatment failure and death.

Case presentation
We present a case report of an acute type B IMH patient with impaired renal function and newly developed ULP in the acute phase. The 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MR) was performed to evaluate the condition of aortic hematoma. The 18F-FDG focal uptake along the aortic wall of the hematoma was normal compared to the background (SUVmax 2.17; SUVSVC 1.6; TBR 1.35). We considered the IMH stable in such cases and opted for medical treatment and watchful observation. Six months after discharge, the patient’s recovery was satisfactory, and aortic remodeling was ideal.

Conclusions
The 18F-FDG PET/MR is a novel tool to evaluate the risk of IMH patients and thus provides information for therapy selection.
Low diagnostic performance of thick blood smears of 50 µl in comparison with direct examination of 10 µl blood and the leukoconcentration technique of 5ml blood among loiasis-suspected patients with low microfilaremia in Gabon, Central Africa, using the STARD-BLCM guidelines
Authors: M’Bondoukwé Noé Patrick , Owono-Medang Matthieu , Moussavou-Boussougou Marie Noëlle , Akoue Yvan , Migueba Valentin , Bulaev Dmitry , Neven Anouk , James Luice Aurtin Joel , Ntsame Ella Sylvie Alberte , Mawili-Mboumba Denise Patricia , Atsame Julienne , Vaillant Michel , Bouyou Akotet Marielle Karine 
Published: March 2024

Abstract
Background
The aim of this study was to determine performance indicators of thick blood smears of 50 µl (TBS-50), following the Standards for the Reporting of Diagnostic Accuracy Studies–Bayesian Latent Class Model (STARD-BLCM) guidelines. TBS-50 was compared with two common parasitological techniques—direct examination of 10 µl blood and a leukoconcentration of 5 ml—for the diagnosis of microfilaremic loiasis.

Methods
The study population was recruited among patients of the Department of Parasitology-Mycology-Tropical Medicine over a period of 1 year. Age, sex, symptoms, and eosinophilia variables were recorded from laboratory registers and medical files. Direct examination of 10 µl of blood, TBS-50, and the leukoconcentration technique with 5 ml of blood were performed for each patient. The classical formula and BLCM were used to determine the diagnostic accuracy of the three techniques as well as the prevalence of microfilaremic loiasis. Three models were built within the framework of BLCM—the BLCM model I and alternative models II and III—for sensitivity analysis.

Results
In total, 191 patients consented to be included. The direct blood examination and TBS-50 yielded comparable qualitative and quantitative results. Hence, they are reported together. The prevalence of Loa loa microfilaremia was 9.4% (95% CI 5.7–14.5; n = 18/191) with direct blood examination/TBS-50 and 12.6% [8.2–18.1] (n = 24/191) for leukoconcentration. Comparing TBS-50 with the leukoconcentration method using the classical formula, the sensitivity was 75.0% [53.3–90.2], specificity was 100.0% [97.8–100.0], the positive predictive value was 100.0% [81.5–100.0], and the negative predictive value was 96.5% [92.6–98.7]. The prevalence of microfilaremic loiasis was estimated at 9.7% [6.2–13.7] using BLCM model I. The outputs of BLCM model I showed sensitivity of 78.9% [65.3–90.3], specificity of 100.0% [99.3–100.0], a positive predictive value of 99.1% [87.2–100.0], and a negative predictive value of 93.0% [87.3–97.7] for direct blood examination/TBS-50.

Conclusions
TBS-50 demonstrates low sensitivity relative to two other techniques. In one in five cases, the result will be falsely declared negative using these methods. However, this method can be deployed with limited funds.

Graphical Abstract
TCP Stratos for stratosphere based computing platforms
Authors: Periola A. A. 
Published: March 2024

AbstractStratosphere computing platforms (SCPs) benefit from free cooling but face challenges necessitating transmission control protocol (TCP) re-design. The redesign should be considered due to stratospheric gravity waves (SGWs), and sudden stratospheric warming (SSWs). SGWs, and SSWs disturb the wireless channel during SCPs packet communications. SCP packet transmission can be done using existing TCP variants at the expense of high packet loss as existing TCP variants do not consider SGWs, and SSWs. TCP variants designed for satellite links are not suitable as they do not explicitly consider the SSW, and SGW. Moreover, the use of SCPs in future internet is at a nascent stage. The presented research proposes a new TCP variant i.e., TCP Stratos. TCP Stratos incorporates a parameter transfer mechanism and comprises loss-based; and delay-based components. However, its window evolution considers the occurrence of SSWs, and SGWs. The performance benefit of the proposed approach is evaluated via MATLAB numerical simulation. MATLAB simulation has been used because of the consideration of the stratosphere. The modelling of the stratosphere in this case is challenging for conventional tools and frameworks. Performance evaluation shows that using TCP Stratos instead of existing TCP variants and improved TCP variants reduces the packet loss rate by an average of (7.1–23.1) % and (3.8–12.8) %, respectively. The throughput is enhanced by an average of (20.5–53)%, and (40.9–70)% when TCP Stratos is used instead of existing TCP variant and modified TCP variant, respectively.
Feasibility of precision smoking treatment in a low-income community setting: results of a pilot randomized controlled trial in The Southern Community Cohort Study
Authors: Lee Scott S. , Senft Everson Nicole , Sanderson Maureen , Selove Rebecca , Blot William J. , King Stephen , Gilliam Karen , Kundu Suman , Steinwandel Mark , Sternlieb Sarah J. , Cai Qiuyin , Warren Andersen Shaneda , Friedman Debra L. , Connors Kelly Erin , Fadden Mary Kay , Freiberg Matthew S. , Wells Quinn S. , Canedo Juan , Tyndale Rachel F. , Young Robert P. , Hopkins Raewyn J. , Tindle Hilary A. 
Published: March 2024

Abstract

Background
The feasibility of precision smoking treatment in socioeconomically disadvantaged communities has not been studied.

Methods
Participants in the Southern Community Cohort Study who smoked daily were invited to join a pilot randomized controlled trial of three smoking cessation interventions: guideline-based care (GBC), GBC plus nicotine metabolism-informed care (MIC), and GBC plus counseling guided by a polygenic risk score (PRS) for lung cancer. Feasibility was assessed by rates of study enrollment, engagement, and retention, targeting > 70% for each. Using logistic regression, we also assessed whether feasibility varied by age, sex, race, income, education, and attitudes toward precision smoking treatment.

Results
Of 92 eligible individuals (79.3% Black; 68.2% with household income < $15,000), 67 (72.8%; 95% CI 63.0–80.9%) enrolled and were randomized. Of these, 58 (86.6%; 95% CI 76.4–92.8%) engaged with the intervention, and of these engaged participants, 43 (74.1%; 95% CI 61.6–83.7%) were retained at 6-month follow-up. Conditional on enrollment, older age was associated with lower engagement (OR 0.83, 95% CI 0.73–0.95, p = 0.008). Conditional on engagement, retention was significantly lower in the PRS arm than in the GBC arm (OR 0.18, 95% CI 0.03–1.00, p = 0.050). No other selection effects were observed.

Conclusions
Genetically informed precision smoking cessation interventions are feasible in socioeconomically disadvantaged communities, exhibiting high enrollment, engagement, and retention irrespective of race, sex, income, education, or attitudes toward precision smoking treatment. Future smoking cessation interventions in this population should take steps to engage older people and to sustain participation in interventions that include genetic risk counseling.

Trial registration: ClinicalTrials.gov No. NCT03521141, Registered 27 April 2018, https://www.clinicaltrials.gov/study/NCT03521141
The relationship between internalised weight bias and biopsychosocial outcomes in children and youth: a systematic review
Authors: Foster Tiarna , Eaton Melissa , Probst Yasmine 
Published: March 2024

Abstract
Objective
To synthesise the evidence on the relationships between internalised weight bias (IWB) and biopsychosocial health outcomes in individuals ≤ 25 years.

Methods
A systematic review was conducted by searching five scientific databases up to May 2022 to retrieve studies that investigated associations between IWB and biopsychosocial outcomes. Articles with participants ≤ 25 years, at least one validated measure of IWB, one measure of a biopsychosocial outcome, and were observational were included. Excluded articles involved systematic literature reviews, case study reports, intervention studies, meta-analyses, grey literature, pilot, and feasibility studies. Quality assessment was carried out using the American Dietetic Association Quality Criteria Checklist. The protocol was registered with PROSPERO, ID number CRD42022323876.

Results
Two hundred and sixty-six articles were identified. Nineteen were eligible for inclusion, (15 cross-sectional and 4 prospective). The Weight Bias Internalization Scale and the Weight Self-Stigma Questionnaire were the most used tools to assess IWB with large heterogeneity in tool types used to assess biopsychosocial measures. IWB had positive associations with psychopathology, eating disorder symptomology, higher BMI, being female, and experiences of weight stigma. It was negatively associated with quality of life, body image, physical activity, social ability, self-esteem, and socioeconomic status.

Discussion
IWB associated with adverse biopsychosocial outcomes in children and youth populations. IWB may be more clinically relevant in assessing at-risk children and youth than physical weight due to its psychosocial aspects and ability to expand beyond the scope of BMI. Research would benefit from better assessment tools designed for children and youth that accurately measure IWB. Future research should focus on increased diversity and longitudinal study designs with children and youth-specific populations.
Intervening factors between risk of violence and aggressive behaviours among forensic inpatients: a scoping review
Authors: Ahmad Badruddin Norhameza , Roseliza-Murni AbRahman , Kamaluddin Mohammad Rahim , Ahmad Badayai Abdul Rahman , Munusamy Shalini 
Published: March 2024

Abstract
Background
Risk of violence is closely associated with aggression propensity. However, there is a lack of research to explain the mechanisms behind this association, especially among the patients of forensic secure facilities. This review aimed to identify and synthesize the available literature concerning the intervening factors (mediating or moderating factors) in the relationship between the risk of violence and aggressive behavior in forensic secure facilities.

Methods
Two electronic academic databases were searched: Scopus and Web of Science (WoS) using specific keywords as search terms derived from the PCC framework with no specific time limit. The search strategy was developed based on the JBI Manual for Evidence Synthesis and utilised the PRISMA-ScR guidelines. Data on the risk of violence, intervening factors, and aggressive behavior were extracted from the included studies. Further analysis was performed whereby similar data were grouped and synthesised together.

Results
The initial search produced 342 studies. However, only nine studies fulfilled the inclusion criteria. The nine studies included 1,068 adult forensic inpatients from various psychiatric hospitals. Only mediation studies reported significant mechanisms of influence between the risk of violence and aggressive behavior. It is postulated that the human agency factor may be the underlying factor that influences a person’s functioning and the subsequent series of events between the risk of violence and aggression.

Conclusions
In light of the paucity of evidence in this area, a generalised conclusion cannot be established. More studies are warranted to address the gaps before conclusive recommendations can be proposed to the relevant stakeholders.
Integration of transcriptomic analysis and multiple machine learning approaches identifies NAFLD progression-specific hub genes to reveal distinct genomic patterns and actionable targets
Authors: Sun Jing , Shi Run , Wu Yang , Lou Yan , Nie Lijuan , Zhang Chun , Cao Yutian , Yan Qianhua , Ye Lifang , Zhang Shu , Wang Xuanbin , Wu Qibiao , Jiao Xuehua , Yu Jiangyi , Fang Zhuyuan , Zhou Xiqiao 
Published: March 2024

Abstract
Background
Nonalcoholic fatty liver disease (NAFLD) is a leading public health problem worldwide. Approximately one fourth of patients with nonalcoholic fatty liver (NAFL) progress to nonalcoholic steatohepatitis (NASH), an advanced stage of NAFLD. Hence, there is an urgent need to make a better understanding of NAFLD heterogeneity and facilitate personalized management of high-risk NAFLD patients who may benefit from more intensive surveillance and preventive intervene.

Methods
In this study, a series of bioinformatic methods were performed to identify NAFLD progression-specific pathways and genes, and three machine learning approaches were combined to construct a risk-stratification gene signature to quantify risk assessment. In addition, bulk RNA-seq, single-cell RNA-seq (scRNA-seq) transcriptome profiling data and whole-exome sequencing (WES) data were comprehensively analyzed to reveal the genomic alterations and altered pathways between distinct molecular subtypes.

Results
Two distinct subtypes of NAFL were identified with the NAFLD progression-specific genes, and one subtype has a high similarity of the inflammatory pattern and fibrotic potential with NASH. The established risk-stratification gene signature could discriminate advanced samples from overall NAFLD. COL1A2, one key gene closely related to NAFLD progression, is specifically expressed in fibroblasts involved in hepatocellular carcinoma (HCC), and significantly correlated with EMT and angiogenesis in pan-cancer. Moreover, the β-catenin/COL1A2 axis might play a critical role in fibrosis severity and inflammatory response during NAFLD-HCC progression.

Conclusion
In summary, our study provided evidence for the necessity of molecular classification and established a risk-stratification gene signature to quantify risk assessment of NAFLD, aiming to identify different risk subsets and to guide personalized treatment.
Extreme precipitation trends in Northeast China based on a non-stationary generalized extreme value model
Authors: Meng Fangxiu , Xie Kang , Liu Peng , Chen Huazhou , Wang Yao , Shi Haiyun 
Published: March 2024

AbstractNortheast China is the main food production base of China. Extreme precipitation (EP) events can seriously impact agricultural production and socioeconomics, but the understanding of EP in Northeast China is still limited. In this study, using the non-stationary generalized extreme value (GEV) model, we investigate the trend and potential risk of EP in Northeast China during 1959–2017, especially in early and mid-summer (periods of high frequency of EP). Then, the relationships between EP and large-scale circulation over Northeast China in early and mid-summer are analyzed separately. The EP in Northeast China mainly presents positive trends in early summer but negative trends in mid-summer. Meanwhile, the EP with all the return periods presents apparently increasing trends in early summer, corresponding to more frequent EP events. Nevertheless, in mid-summer, the EP with 2-year return period decreases with location parameter, and the EP with 20-year, 50-year, and 100-year return periods slightly increases with scale parameter. The EP with 2-year return period occurs frequently in Liaoning Province, while the EP with 100-year return period is more likely to occur in Jilin Province and Heilongjiang Province. Moreover, the increase of the EP in early summer is mainly influenced by the northeast cold vortex; the effect of cold air on the EP is stronger in mid-summer, giving a clear explanation why the EP in mid-summer does not increase significantly. Overall, the outcomes of this study would be beneficial for the disaster prevention and mitigation in Northeast China.
Fake human but real influencer: the interplay of authenticity and humanlikeness in Virtual Influencer communication?
Authors: Ju Naan , Kim Terry , Im Hyunjoo 
Published: March 2024

AbstractRecently, there has been a lot of interest in industry and academia in virtual influencers (VIs). This study aimed to augment the understanding of VI marketing by exploring the relationship between VI’s characteristics (i.e., their humanlikeness level and operator type), their social media post characteristics (i.e., emotional expression, use of pronouns, use of punctuation marks), and consumer engagement. The analysis of three popular VIs’ Instagram profiles and posts revealed that VIs with less humanlike appearances tend to exhibit stronger positive emotional expressions. Interestingly, the level of humanlikeness in appearance was not associated with VI's other post characteristics, suggesting other intrinsic factors (e.g., the VI’s character and virtual universe) may play a pivotal role. Whether a brand operates the VI or not made a statistically significant difference in the VI’s post characteristics. Assessment of user engagement metrics (i.e., number of likes and comments) showed that users prefer hyper-realistic VIs and VIs operated by non-brand agencies, underscoring the importance of perceived authenticity in the digital realm. The emotions expressed by VIs, along with their use of punctuation, were positively related to user engagement.
Successful management of splenic artery dissection after sigmoid colon perforation in vascular Ehlers–Danlos syndrome
Authors: Yoshizaki Moegi , Matsuo Yasuko , Yasuda Satoshi , Doi Shunsuke , Sakata Takeshi , Nagai Minako , Nakamura Kota , Kohara Yuichiro , Toyoda Shohei , Tanaka Toshihiro , Sho Masayuki 
Published: March 2024

Abstract
Background
Ehlers–Danlos syndrome (EDS) is a genetic disorder that causes fragility of the systemic connective tissues. Of the 13 subtypes, vascular EDS (vEDS) is associated with abnormalities in collagen production, resulting in arterial rupture and intestinal perforation. Herein, we report the case of a man with confirmed vEDS who survived a ruptured dissected splenic artery aneurysm triggered by perforation of the sigmoid colon.

Case presentation
A 48-year-old man presented to our hospital with sudden severe lower abdominal pain. The patient was genetically diagnosed with vEDS at the age of 43 years. Abdominal computed tomography (CT) showed fluid and free air surrounding the sigmoid colon. These findings suggested sigmoid colon perforation, and emergency surgery was needed. Hartmann’s procedure was performed. The resected specimen showed a 2-cm-sized depression around the perforation. Histopathological findings showed an abscess and exudate in the serosa of the perforation and thinning of the intrinsic muscular layer in the depressed area. The patient was doing well postoperatively; however, on the ninth postoperative day, sudden upper abdominal pain developed. CT revealed an intra-abdominal hemorrhage due to rupture of a dissecting splenic artery aneurysm. The aneurysm was not observed on preoperative CT and was distant from the surgical site. Urgent transcatheter arterial embolization was performed. Although embolization of the splenic artery was attempted during the procedure, the arterial dissection spread to the common hepatic artery. Moreover, the proper hepatic and gastroduodenal arteries were poorly visualized, probably due to vasospasm. Although complications associated with extensive embolization were a concern, embolization of the splenic and common hepatic arteries was necessary to save the patient’s life. After embolization, angiography showed that the left hepatic blood flow was maintained from the inferior phrenic artery, and the right hepatic inflow was maintained from the superior mesenteric artery via the peribiliary vascular plexus in the hilar area. The patient recovered well and was discharged on the 19th postoperative day.

Conclusions
vEDS can cause arterial rupture after intestinal surgery. Therefore, careful post-operative management is necessary. Moreover, cooperation with interventional radiologists is important for prompt treatment of vascular complications.
A systematic review of the effects of hepatitis B and C virus on the progression of liver fluke infection to liver cancer
Authors: O’Rourke Allison 
Published: March 2024

AbstractHepatitis B and C virus, Opisthorchis viverrini and Clonorchis sinensis, are all individually known to put a person at increased risk for cholangiocarcinoma and hepatocellular carcinoma. This paper seeks to determine if there is any interaction between liver flukes and hepatitis virus infection that are known to put a person at an increased risk for cholangiocarcinoma and hepatocellular carcinoma collectively. This paper seeks to determine whether there is any publicly available articles in English that determine if having a hepatitis viral co-infection along with liver flukes would influence the risk of developing liver cancer. We followed PRISMA systematic review guidelines to conduct a literature review. Three manuscripts fit the search criteria. Two presented evidence in support of a synergistic relationship between liver fluke and viral hepatitis infection while the other found no relationship. One manuscript determined that the interaction between hepatitis B and C. sinensis did not have any significant risk of liver cancer. Studies found that HBV affected progression of co-infection to liver cancer but may have its own disease state worsened by presence of liver flukes. Only one paper was found that presented data on HCV, therefore no conclusion can be drawn due to the lack of evidence discovered. Of the studies, the conclusions and strength of the data were mixed. However, the stronger studies suggested a synergistic relationship between liver flukes and HBV to increase the risk of progressing to liver cancer.