bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technology Experiences in Initial Teacher Education: A Systematic Review
Authors: Prates Uaiana , Cruz Mário , Mascarenhas Daniela , Maia-Lima Cláudia 
Published: February 2025

Abstract
The integration of technology in preservice teacher education is a critical aspect of preparing educators for the contemporary classroom. This systematic review, conducted from 2013 to 2023, seeks to provide a comprehensive understanding of technological experiences within teacher education programs. Using an aggregative database and applying rigorous inclusion and exclusion criteria, the search yielded a final selection of studies that shed light on technological experiences in initial teacher training programs. The primary objectives included identifying studies discussing technological experiences in preservice teacher education, categorizing them based on theoretical frameworks and methodologies, and analyzing the format of these experiences. The dominant theoretical framework emerging from our review is technological pedagogical content knowledge. We found that universities offer a diverse range of courses in technology for preservice teachers, but only 26% of these programs emphasize practical applications in a practicum context. This study contributes to the ongoing discourse on the role of technology in education by offering insights into the current landscape and recommending avenues for improvement. Policymakers and educators can utilize this information to enhance preservice teacher education programs, ensuring that prospective educators are well-equipped to navigate the demands of technology-enhanced teaching environments.
A promising Ag2S/poly-2-amino-1-mercaptobenzene open-top spherical core–shell nanocomposite for optoelectronic devices: A one-pot technique
Authors: Alkallas Fatemah H. , Rabia Mohamed , Trabelsi Amira Ben Gouider , Alrebdi Tahani A. , Elsayed Asmaa M. 
Published: February 2025

Abstract
Herein, we have introduced a novel and promising optoelectronic device, the Ag2S/poly-2-amino-1-mercaptobenzene open-top spherical core–shell nanocomposite (Ag2S/P2AMB CS-nanocomposite), fabricated using cost-effective and scalable production techniques. This device demonstrates high potential in sensing photons with various energies across a broad spectrum region, ranging from near-IR to UV. The Ag2S/P2AMB CS-nanocomposite, with its unique bandgap of 1.7 eV, broad optical absorbance, estimated crystalline size of 69 nm, and open spherical nanoparticles, is a significant advancement in the field of optoelectronics. The fabricated thin film device can detect photons with energies from 1.7 to 3.6 eV, corresponding to the near-IR and UV regions. Its sensitivity is measured through parameters such as the produced photocurrent density (J
ph), photoresponsivity (R), and detectivity (D). The device can generate a photocurrent of 0.025 mA/cm², based on the difference between J
ph and dark current (J
o) values. As the wavelengths increase from 340 to 730 nm, J
ph decreases from 0.039 to 0.028 mA/cm². The responsivity (R) ranges from 0.4 to 0.36 mA/W, while the detectivity (D) varies from 0.91 × 108 to 0.82 × 108 Jones at a small bias voltage of 2.0 V. These promising values indicate that the fabricated optoelectronic device is highly sensitive to photons. Its efficient performance, simple preparation, and cost-effective techniques estimate it as a strong recommendation for industrial applications, ensuring its economic viability.
Serotonergic input into the cerebellar cortex modulates anxiety-like behavior
Authors: Chin Pei Wern , Augustine George J. 
Published: February 2025

Because of the important roles of both serotonin (5-HT) and the cerebellum in regulating anxiety, we asked whether 5-HT signaling within the cerebellum is involved in anxiety behavior. Physiological 5-HT levels were measured in vivo by expressing a fluorescent sensor for 5-HT in lobule VII of the cerebellum, while using fiber photometry to measure sensor fluorescence during anxiety behavior on the elevated zero maze. Serotonin increased in lobule VII when male mice were less anxious and decreased when mice were more anxious. To establish a causal role for this serotonergic input in anxiety behavior, we photostimulated or photoinhibited serotonergic terminals in lobule VII while mice were in an elevated zero maze. Photostimulating these terminals reduced anxiety behavior in mice, while photoinhibiting them enhanced anxiety behavior. Our findings add to evidence that cerebellar lobule VII is a topographical locus for anxiety behavior and establish that 5-HT input into this lobule is necessary and sufficient to bidirectionally influence anxiety behavior. These results represent progress toward understanding how the cerebellum regulates anxiety behavior and provide new evidence for a functional connection between the cerebellum and the serotonin system within the anxiety circuit.Significance StatementThis is the first analysis of the involvement of the neuromodulator, serotonin, in the cerebellum during anxiety behavior. Our results reveal that serotonin regulates anxiety behavior. This offers new insight into the role of serotonin in the cerebellum, as well as illuminating how the cerebellum interacts with the rest of the brain to produce anxiety. Our results are important for future use of serotonin-related pharmacological therapeutics, such as selective serotonin-reuptake inhibitors, in treating anxiety in humans.
Differential antibiosis predisposes mice to Campylobacter jejuni infection: Deeper insights into the impact of the gut microbiota composition in colonization resistance
Authors: Shayya Nizar W. , Mousavi Soraya , Stingl Kerstin , Bereswill Stefan , Heimesaat Markus M. 
Published: February 2025

AbstractConventional laboratory mice are protected from oral Campylobacter jejuni infection due to colonization resistance (CR) mediated by their host-specific gut microbiota. Here, we used differential effects of distinct antibiotics on gut microbiota composition to identify microbial groups associated with CR against C. jejuni. Therefore, specific pathogen-free (SPF) mice were subjected to ampicillin plus sulbactam (A/S), ciprofloxacin (CIP), or vancomycin (VAN) via the drinking water for 28 days or left untreated before peroral C. jejuni challenge. Cultural analyses revealed that CR displayed by untreated mice was abrogated by A/S treatment, but only reduced in mice treated with CIP or VAN. Notably, differential analysis of antibiotic-induced microbiota changes and C. jejuni colonization dynamics identified lactobacilli and Clostridium leptum as key microbial groups that were associated with CR. Notably, the complete eradication of intestinal bacteria in A/S treated mice supported high intestinal C. jejuni colonization levels which triggered apoptosis and inflammatory responses accompanied by enhanced expression of matrix-degrading gelatinases in the colon. In conclusion, A/S treated mice represent a valuable infection model for the study of campylobacteriosis and the treatment of mice with specific antibiotics support the investigation of molecular mechanisms involved in CR against enteropathogens.
Determining the research priorities for the profession of Occupational Therapy in South Africa
Authors: Soeker Mogammad Shaheed , Olaoye Olumide 
Published: February 2025

Occupational Therapy is a profession that focuses on enhancing the functioning of individuals who experience functional limitations particularly when engaging in occupation related activities. The setting of research priorities is seen as an important activity for every organisation. The aim of the study was to determine the current occupational therapy research focus areas in South Africa and to establish occupational therapy priority research areas. In Phase one of the study the researchers conducted a survey with 150 participants in order to determine the research priority focus areas for the profession of occupational therapy. In Phase two a database consisting of research projects completed for the year 2017- 2019 were analysed thematically in order to determine the current main areas of occupational therapy research in South Africa. A quantitative descriptive research design was used in Phase one of the study and Phase two used a qualitative research design.Â The WHO research priority questionnaire was used to identify research priorities for the occupational therapy profession. The results of Phase one of the study indicate that Effectiveness of occupational therapy intervention (n, 74%), evidence based occupational therapy practice (n, 67%) and the development of valid and reliable occupational therapy measurement tools (n, 57%) was seen as important areas in terms of research priority. Furthermore, the results of Phase two of the study indicates that OT Education and training-based research [58%] and Mental Health Disorders (including substance abuse) [49%] were the most common areas of occupational therapy research in South Africa. In conclusion the results of the study suggested a need to conduct Level 1 studies that require evidence based occupational therapy practice.
Penggunaan Teknologi Hidroponik dalam Budidaya Sayuran di Era Generasi Muda
Authors: Fitriyani Nurzalifa , Rozaki Zuhud , Wulandari Retno , Suryani Cahyaningrum Arie 
Published: February 2025

This article explores the utilisation of hydroponic technology in vegetable cultivation among the younger generation. It aims to determine the factors that influence the interest of the younger generation in using hydroponic technology for vegetable cultivation, as well as the challenges, advantages and disadvantages of the method. In addition, it examines the potential business opportunities associated with the use of hydroponic technology. The research methodology used in this study involved the use of secondary data and data analysis techniques. The research findings show that there are several factors that influence the interest of the younger generation in utilising hydroponic technology for vegetable cultivation. These factors include environmental concerns, limited space availability, and the desire for organic and sustainable food production. Furthermore, the research revealed that hydroponic technology offers various advantages, such as efficient water usage and higher yields. However, it also poses certain challenges, including initial investment costs and the need for proper maintenance. The study concluded that the utilisation of hydroponic technology in vegetable cultivation provides a huge business opportunity. The demand for hydroponic vegetables continues to increase, along with the increasing public awareness of the importance of consuming healthy and quality vegetables. In addition, hydroponic technology can also be used for the cultivation of various types of vegetables, so the business opportunities are vast. The findings of this study contribute to the existing knowledge by highlighting the factors that influence the younger generation's interest in hydroponic technology and provide insights into the challenges, advantages and disadvantages, methods, and business opportunities in the use of hydroponic technology.
Traumatic stress alters neural reactivity to visual stimulation
Authors: Harnett Nathaniel , Rowland Grace , Webb E Kate , Li Tianyi , Joshi Soumyaa , Ressler Kerry , Rosso Isabelle 
Published: February 2025

Abstract

Traumatic stress is a precursor to the development of posttraumatic stress disorder (PTSD). Emergent research suggests visual processing regions may be relevant to PTSD development; however, no previous research to date has investigated the potential effects of trauma exposure on neural reactivity to non-affective visual stimulation. In the present study, 24 recently trauma-exposed (TE) and 16 without recent exposure to trauma (NTE) individuals completed functional magnetic resonance imaging during alternating blocks of flickering checkerboard presentations and rest with an attentional check. TE participants were recruited within 2–4 weeks of trauma, and PTSD symptoms were assessed both at the time of the magnetic resonance imaging scan and 6 months following trauma exposure. TE participants showed greater deactivation within the visual cortex compared to NTE participants. Further, NTE participants showed greater neural reactivity within the dorsomedial prefrontal cortex during stimulation compared to rest, while no difference was observed in TE participants. Connectivity analyses also revealed that visual cortex to paracentral gyrus connectivity was greater during stimulation compared to rest, but only for the NTE participants. Finally, neural reactivity to visual stimulation was negatively associated with PTSD symptoms within the TE group. Our findings suggest that trauma exposure is associated with acute alterations in the neural function that underlies basic visual processing. Furthermore, trauma-induced variability in visual circuit function may be related to the development and expression of PTSD symptoms.
Introduction of multiple disulfide bonds increases the thermostability of transglutaminase
Authors: Ono Takuto , Takahashi Kazutoshi , Hirao Yoshinori , Mihara Yasuhiro , Abe Isao , Sugiki Masayuki 
Published: February 2025

Abstract

Microbial transglutaminase (MTG) is an enzyme that catalyzes the cross-linking of glutamine and lysine residues in proteins. Because of its ability to modify proteins, MTG has various applications in the medical and food industries. Most studies have aimed to enhance the thermal stability of MTG by focusing only on point mutations. Introducing a disulfide (S-S) bond in the N-terminal region has been found to be effective, whereas S-S bonds in other regions were considered ineffective. Therefore, this study aimed to evaluate the impact of introducing an additional S-S bond on the thermal stability of an MTG mutant. We found that adding S-S bonds to regions other than the N-terminal, in conjunction with the N-terminal S-S bond, significantly enhanced thermal stability. This finding demonstrates the importance of reinforcing the weakest part of the protein first, followed by strengthening other regions for optimal thermal stability. The MTG variant with two S-S bonds retained its catalytic activity and substrate specificity towards protein substrates, making it a promising candidate for industrial applications. Thus, introducing S-S bonds could be an effective strategy to increase thermal stability of MTG and other industrial enzymes, thereby contributing to their potential industrial applications.
Enterotoxigenic Escherichia coli heat labile enterotoxin induces cell death and disrupts effector functions of porcine monocytes
Authors: Ma Jinglin , Weken Hans Van der , Hermans Leen , Dierick Matthias , Cox Eric , Devriendt Bert 
Published: February 2025

Abstract

Enterotoxigenic Escherichia coli (ETEC) is a common cause of diarrhea in human and animals, including pigs. Enterotoxins are important virulence factors for ETEC. Although a lot is known on the mechanism of enterotoxin-induced diarrhea, less is known about their effects on innate immune cells like monocytes. Monocytes can differentiate into macrophages and dendritic cells and play a pivotal role as a bridge between the innate and adaptive immune system. Understanding the interaction between ETEC enterotoxins and monocytes can help in the development of more effective preventive and therapeutic strategies to combat this disease. In this study, we aimed to investigate the effects of the heat labile enterotoxin (LT) and the heat stable enterotoxin a (STa) produced by ETEC on porcine monocytes. Our results show that STa did not affect the cell viability and effector functions of monocytes. LT, on the other hand, decreased the cell viability of monocytes. While LT did not alter the production of reactive oxygen species (ROS) production by monocytes, it significantly reduced ROS production induced by phorbol 12-myristate 13-acetate (PMA). In addition, LT decreased the phagocytosis of E. coli by monocytes and enhanced the survival of intracellular ETEC. Furthermore, LT triggered the production of cytokines IL-1β, IL-6 and TNF-α as well as chemokines CCL-3 and CXCL-8. Together, our results show that in contrast to STa, LT can cause cell death in monocytes and disrupt their immune effector functions, potentially acting as an immune evasion strategy to establish infection.
Effect of Injection Molding Parameters and Cooling Conditions on the Dimensional Stability and Mechanical Properties of Polypropylene Battery Boxes for Automotive Batteries
Authors: Switzner Nathaniel , Abubakr Dyari Omed , AbdulAziz Nouf Nawaf , Rasheed Fahad Faris , Jamal Lano Hunar 
Published: February 2025

Abstract

This study investigates the influence of injection molding parameters, including tem-perature, cooling duration, and coolant flow conditions, on the dimensional stabilityand mechanical properties of automotive battery boxes made from polypropylene im-pact copolymer (PPIC). PPICs are widely used materials for battery boxes becauseof their strength, toughness, chemical resistance, and low cost. Interruption of theflow of coolant to the mold was shown to cause warpage in specific regions. Lowerinjection temperatures (220 °C) showed greater robustness to coolant anomalies,maintaining dimensional stability despite cooling disruptions.

Mechanical testing of tensile bars extracted from the molded boxes revealed sig-nificant orientation-dependent behavior, with longitudinal samples exhibiting supe-rior elongation and toughness compared to transverse samples. Notched tensile barsconfirmed strain rate sensitivity, highlighting the brittleness of PPIC under highdeformation rates. A machine learning model was used to optimize elongation as afunction of processing parameters, revealing optimal ranges for injection temperature(220–234 °C) and cooling time (38-47 s).

These findings provide actionable insights for optimizing the injection moldingprocess to minimize defects, enhance mechanical performance, and improve reliabilityin PPIC battery boxes. Future work should focus on exploring additional parame-ters, including resin composition and mold design, to further refine manufacturingoutcomes.
Multi-objective Aerodynamic Design Optimization of a New Engine Intake Electromagnetic Wave Blocker
Authors: Üstün Cihat Emre , Ünal İlhami , Özbey Nurettin , Kılıç Nail Buğra , Erdoğan Nursev , Altay Özkan , Tutar Mustafa 
Published: February 2025

Abstract

A new engine intake electromagnetic wave blocker (EMWB) in astraight duct configuration is proposed as an alternative to S-shaped air intake ducts for reducing radar and infrared signatures of aircraft. A computational fluid dynamics model is developed and verified against an existing S-duct air intake study. Ten geometric parameters of the baseline EMWB are selected as design variables for a multi-objective optimization study. The design space is extensively explored with 68 configurations, applying the constraints of pressure recovery (PR) > 0.97 and distortion coefficient (DC60) <0.06. This process yields 16 feasible designs, from which the best performing model in terms of PR and DC60 is selected as the optimized EMWB. The electromagnetic model and experimental set-up are then established. Radar cross section measurements of the optimized EMWB model demonstrate significant improvements: aerodynamic performance is increased by 8.1% for PR and 14% for DC60, while the radar cross section is decreased by 51%. These results suggest that the optimized EMWB in a straight duct configuration offers a promising alternative to S-shaped ducts for reducing aircraft engine signatures while maintaining aerodynamic performance.
Macroinvertebrate predators and other coexisting macroinvertebrate species interaction with malaria vectors in aquatic habitats of three climatic areas of Burkina Faso
Authors: Ouedraogo Judicael , Sawadogo Simon P. , Niang Abdoulaye , Soulama Abdoulaye , Yerbanga Sylvie , Ouédraogo Tarwendpanga F.X. , Séré Bouraïma Vincent , Guissou Charles , Dabiré Roch K. , Müller Ruth , Gnankine Olivier , Diabaté Abdoulaye 
Published: February 2025

Abstract

Background: In aquatic larval habitats, Anopheles larvae are subject to the predatory activity of macroinvertebrates. These macroinvertebrates may play a key role in the Anopheles populations bioregulation in aquatic habitats and malaria control. There are few studies characterising macroinvertebrate predators and other macroinvertebrates coexisting with Anopheles larvae in Burkina Faso. This study aimed at characterising and evaluating the different interactions in larval habitats between anopheline mosquito larvae, predatory macroinvertebrates and other co-habitants in the three climatic areas of Burkina Faso.
Methods: A larval survey was performed in the three climatic areas (Sahelian, Soudano-Sahelian and Soudanian zones) from September to November 2022. Mosquito larvae and other macroinvertebrates were sampled using standard dippers, preserved in Falcon tubes containing ethanol 80% and transported to the laboratory for morphological identification. Alpha diversity analysis was used to measure macroinvertebrate diversity according to climatic zones and correlation matrix analysis was performed to determine the different interactions between Anopheles and other macroinvertebrates in breeding sites.
Results: As results, in larval habitats, Anopheles were found with several aquatic macroinvertebrate predators and other macroinvertebrates cohabiting with Anopheles. The abundance and alpha diversity indices of macroinvertebrate predators and other coexisting macroinvertebrates varied significantly according to climatic zone. Correlation analyses showed that in the Sahelian zone, Anopheles spp., Corixidae and Notonectidae shared the same aquatic habitats. In the Soudano-Sahelian zone, Anopheles spp. occupied the same larval habitats with Belostomatidae, Notonectidae and Achatinidae and the presence of Anopheles in larval habitats was correlated with that of Beatidae in the Soudanian zone.
Conclusion: This study showed a trophic association between Anopheles, macroinvertebrate predators and other coexisting macroinvertebrates in larval habitats in Burkina. Our study provides insights and thereby opens new avenues in terms of development of biological control against larvae of Anophelespopulations in Burkina Faso.