bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deubiquitinase UCHL1 promotes angiogenesis and blood–spinal cord barrier function recovery after spinal cord injury by stabilizing Sox17
Authors: Wang Jiaxing , Ji Chengyue , Ye Wu , Rong Yuluo , Ge Xuhui , Wang Zhuanghui , Tang Pengyu , Zhou Zheng , Luo Yongjun , Cai Weihua 
Published: March 2024

AbstractImproving the function of the blood–spinal cord barrier (BSCB) benefits the functional recovery of mice following spinal cord injury (SCI). The death of endothelial cells and disruption of the BSCB at the injury site contribute to secondary damage, and the ubiquitin–proteasome system is involved in regulating protein function. However, little is known about the regulation of deubiquitinated enzymes in endothelial cells and their effect on BSCB function after SCI. We observed that Sox17 is predominantly localized in endothelial cells and is significantly upregulated after SCI and in LPS-treated brain microvascular endothelial cells. In vitro Sox17 knockdown attenuated endothelial cell proliferation, migration, and tube formation, while in vivo Sox17 knockdown inhibited endothelial regeneration and barrier recovery, leading to poor functional recovery after SCI. Conversely, in vivo overexpression of Sox17 promoted angiogenesis and functional recovery after injury. Additionally, immunoprecipitation-mass spectrometry revealed the interaction between the deubiquitinase UCHL1 and Sox17, which stabilized Sox17 and influenced angiogenesis and BSCB repair following injury. By generating UCHL1 conditional knockout mice and conducting rescue experiments, we further validated that the deubiquitinase UCHL1 promotes angiogenesis and restoration of BSCB function after injury by stabilizing Sox17. Collectively, our findings present a novel therapeutic target for treating SCI by revealing a potential mechanism for endothelial cell regeneration and BSCB repair after SCI.
The 2023 Nobel Prize in Chemistry: Quantum dots
Authors: Wegner K. David , Resch-Genger Ute 
Published: March 2024

AbstractThe 2023 Nobel Prize in Chemistry was awarded to Aleksey I. Ekimov (prize share 1/3), Louis E. Brus (prize share 1/3), and Moungi G. Bawendi (prize share 1/3) for groundbreaking inventions in the field of nanotechnology, i.e., for the discovery and synthesis of semiconductor nanocrystals, also termed quantum dots, that exhibit size-dependent physicochemical properties enabled by quantum size effects. This feature article summarizes the main milestones of the discoveries and developments of quantum dots that paved the road to their versatile applications in solid-state lighting, display technology, energy conversion, medical diagnostics, bioimaging, and image-guided surgery.
Migratory Shorebird Gut Microbes are not Associated with Bivalve Prey in Monsoon Tropical Australia
Authors: Weitzman Chava L. , Tinning Zarah , Day Kimberley A. , Garnett Stephen T. , Christian Keith , Gibb Karen 
Published: March 2024

AbstractMigratory animals can carry symbionts over long distances. While well-studied for parasite and pathogen transmission, less is known about use of this route by other symbiotic taxa, particularly those non-pathogenic. Here we ask the question of whether gut bacteria can be spread between continents by long-distance bird migration, although gut microbiomes in birds may not be as stable or persistent as those of non-volant animals. We used amplicon sequencing of both bacterial 16S rRNA gene and Vibrio-centric hsp60 gene to determine whether the faecal bacteria of migratory great knots (Calidris tenuirostris) also occur in their main food source in Northern Australia or in nearby sand, comparing samples before and after the birds’ long-distance migration. Our data suggest that there is little connectivity among the bacterial microbiomes, except in the bivalve prey. Our results are consistent with previous studies finding that bird faecal microbiomes were not host-specific and contrast with those showing an influence of diet on bird faecal bacteria. We also found little connectivity among Vibrio spp. However, although faecal sample sizes were small, the dominance of different individual Vibrio spp. suggests that they may have been well-established in knot guts and thus capable of moving with them on migration. We suggest that the physiological impacts of a long-distance migration may have caused shifts in the phyla comprising great knot faecal communities.
Transient ureteral obstruction after mini-percutaneous nephrolithotomy is associated with stone volume and location: results from a single-center, real-life study
Authors: Nizzardo Marco , Zanetti Stefano Paolo , Marmiroli Andrea , Lucignani Gianpaolo , Turetti Matteo , Silvani Carlo , Gadda Franco , Longo Fabrizio , De Lorenzis Elisa , Albo Giancarlo , Salonia Andrea , Montanari Emanuele , Boeri Luca 
Published: March 2024

Abstract
Purpose
To evaluate the rate of and predictors of ureteral obstruction after mini-percutaneous nephrolithotomy (mPCNL) for kidney stones.

Methods
We analyzed data from 263 consecutive patients who underwent mPCNL at a single tertiary referral academic between 01/2016 and 11/2022. Patient’s demographics, stone characteristics, and operative data were collected. A nephrostomy tube was placed as the only exit strategy in each procedure. On postoperative day 2, an antegrade pyelography was performed to assess ureteral canalization. The nephrostomy tube was removed if ureteral canalization was successful. Descriptive statistics and logistic regression models were used to identify factors associated with a lack of ureteral canalization.

Results
Overall, median (IQR) age and stone volume were 56 (47–65) years and 1.7 (0.8–4.2) cm3, respectively. Of 263, 55 (20.9%) patients showed ureteral obstruction during pyelography. Patients without ureteral canalization had larger stone volume (p < 0.001), longer operative time (p < 0.01), and higher rate of stones in the renal pelvis (p < 0.01) than those with normal pyelography. Length of stay was longer (p < 0.01), and postoperative complications (p = 0.03) were more frequent in patients without ureteral canalization. Multivariable logistic regression analysis revealed that stone volume (OR 1.1, p = 0.02) and stone located in the renal pelvis (OR 2.2, p = 0.04) were independent predictors of transient ureteral obstruction, after accounting for operative time.

Conclusion
One out of five patients showed transient ureteral obstruction after mPCNL. Patients with a higher stone burden and with stones in the renal pelvis are at higher risk of inadequate ureteral canalization. Internal drainage might be considered in these cases to avoid potential complications.
The dynamics of the El Niño–Southern Oscillation diversity in the recharge oscillator framework
Authors: Priya Priyamvada , Dommenget Dietmar , McGregor Shayne 
Published: March 2024

AbstractThis study investigates the observed El Niño-Southern Oscillation (ENSO) dynamics for the eastern Pacific (EP) and central Pacific (CP) events in reference to the canonical ENSO (T). We use the recharge oscillator (ReOsc) model concept to describe the ENSO phase space and polar coordinate statistics, based on the interaction of sea surface temperature (T) and thermocline depth (h), for the different types of ENSO events. We further look at some important statistical characteristics, such as power spectrum and cross-correlation as essential parameters for understanding the dynamics of ENSO. The results show that the dynamics of the EP and CP events are very different from each other and from the canonical ENSO events. The canonical ENSO (T) events fit closest to the idealised ReOsc model and has the most clearly oscillating ENSO phase space, suggesting it is the most predictable ENSO index. The EP phase space evolution is similar to the canonical ENSO, but the phase transitions are less clear, suggesting less of an oscillatory nature and that the index is more focussed on extreme El Niño and discharge states. The CP phase space, in turn, does not have a clear propagation through all phases and are strongly skewed towards the La Niña state. The interaction between CP and h are much weaker, making the mode less predictable. Wind forced shallow water model simulations show that the CP winds spatial pattern do not force significant h tendencies, strongly reducing the delayed negative feedback, which is essential for the ENSO cycle.
Marked increase in severe neurological disorders after nitrous oxide abuse: a retrospective study in the Greater Paris area
Authors: Dawudi Yachar , Azoyan Loris , Broucker Thomas D. E. , Gendre Thierry , Miloudi Amal , Echaniz-Laguna Andoni , Mazoyer Julie , Zanin Adrien , Kubis Nathalie , Dubessy Anne-Laure , Gorza Lucas , Ben Nasr Haifa , Caré Weniko , d’Izarny-Gargas Thibaut , Formoso Aude , Vilcu Ana-Maria , Bonnan Mickael 
Published: March 2024

Abstract
Background
Recreational nitrous oxide (N2O) use has become more widespread worldwide, leading to an increase in myelopathies and peripheral neuropathies. The aim of this study was to describe clinical and socioeconomical characteristics of severe N2O-induced (NI) neurological disorders (NI-NDs), to determine its incidence in the Greater Paris area and to compare it with that of similar inflammatory neurological disorders.

Methods
We performed a retrospective multicentric cohort study of all adult patients with severe NI-NDs in the neurology and general internal medicine departments of the Greater Paris area from 2018 to 2021. The incidence was compared with that of non-NI-myelitis and Guillain–Barré syndrome (GBS) using a sample of 91,000 hospitalized patients sourced from health insurance data.

Results
Among 181 patients, 25% had myelopathy, 37% had peripheral neuropathy and 38% had mixed disease. Most were aged between 20 and 25 years, lived in socially disadvantaged urban areas, and exhibited high rates of unemployment (37%). The incidence of NI-NDs increased during 2020 and reached a peak mid-2021. The 2021 incidence in 20–25-year-olds was 6.15 [4.72; 8.24] per 100,000 persons for NI-myelopathy and 7.48 [5.59; 9.37] for NI-peripheral neuropathy. This was significantly higher than for non-NI-myelitis (0.35 [0.02; 2.00]) and GBS (2.47 [0.64; 4.30]). The incidence of NI-NDs was two to three times higher in the most socially disadvantaged areas.

Conclusion
The recent increase in recreational N2O use has led to a rise in the incidence of severe NI-NDs, particularly in young adults with low socioeconomic status for whom NI-NDs strongly outweigh similar neurological disorders.
Retrospective evaluation of Penguin Cold Caps for chemotherapy-induced alopecia
Authors: Weaver Dale , Pershing Michelle L. , Golden Bethany , Hammel Laura , Russ Pauline Kefalas , Cripe Mark 
Published: March 2024

Abstract
Background
Scalp cooling is an increasingly recognized non-pharmacologic approach to minimize chemotherapy-induced alopecia (CIA). Several commercially available machine-based and manual scalp cooling systems are available; however, literature reports of effectiveness are highly variable. The purpose of this study was to determine real-world tolerability and subjective effectiveness of a manual cold capping system in minimizing CIA across a variety of patient race and hair types. This study was a single-institution review of outcomes from manual cold capping.

Methods
We identified retrospective cohort of adult patients who presented to discuss cold capping between January 14, 2019, and March 31, 2022. Data collected from medical records included demographics, decision to pursue/continue cold capping, diagnoses, chemotherapy regimens, hair characteristics (length, thickness, coarseness, type), and subjective perception of percentage of hair retained. Those with successful vs. unsuccessful cold capping (≥ 50% vs. < 50% of hair retained) were compared based on the patient-level factors of interest.

Findings
A total of 100 patients initiated cold capping during the study period, and 95% of them completed cold capping. The majority of patients who started cold capping completed it. The median-reported percentage of hair maintained was 75%, and 82/89 (92.1% of patients) had favorable results, defined as ≥ 50% of hair retained. The only patient-level factor associated with favorable response was chemotherapy regimen, with fewer patients receiving doxorubicin-containing regimens having successful hair retention compared to other chemotherapy types (71.4% successful results vs. 95.7% for those receiving paclitaxel-containing regimens and 96.6% for those receiving docetaxel-containing regimens (p = 0.018). There was no difference in success based on patient race/ethnicity or hair characteristics.

Interpretation
The overall effectiveness (92.1%) in this study is consistent to higher than many literature reports. One possible reason for the high success in our cohort is compliance with cold capping protocols, meaning applying the cap in the appropriate manner and wearing the cap for the prescribed durations, which may impact effectiveness.
Implementing a cancer survivorship seminar course to non-healthcare professional undergraduate students
Authors: Chan Alexandre 
Published: March 2024

Abstract
Background
At University of California, Irvine (UCI), a seminar course focused on cancer survivorship was developed and offered to non-healthcare professional undergraduate students. Utilizing the knowledge, attitude, and perception (KAP) framework, this study was designed to examine the impact on students who have taken this course, and to clarify the value of this course for undergraduate students.

Methods
This was a cross-sectional survey. Undergraduate students enrolled in the Life After Cancer Freshmen Seminar course (Uni Stu 3) at UCI between 2021 and 2023 were invited to participate. The survey consisted of 4 main sections: (1) demographics, (2) knowledge of cancer survivorship, (3) attitude towards cancer survivorship, and (4) perception and awareness of cancer survivorship. The survey was administered prior to the implementation of the course, and the same survey was administered at the end of the course.

Results
A total of 33 students completed the pre-implementation survey and 30 students completed the post-implementation survey. Comparing pre- and post-course implementation, there was an increase of perception and awareness of (i) resources and guidelines for cancer survivors (pre, 9.1% vs. post, 36.7%), (ii) mental health complications among cancer survivors (pre, 36.4% vs. post, 56.7%), (iii) benefits of cancer survivorship care (pre, 15.2% vs. post, 40%), latest research in cancer survivorship (pre, 0% vs. post, 23.3%), and (iv) tailoring survivors’ needs according to their age groups (pre, 24.2% vs. post, 66.7%). Knowledge and attitude towards caring of cancer survivors were similar comparing pre- and post-course implementation.

Conclusion
In an undergraduate seminar course focused on cancer survivorship, we observed an improvement of non-healthcare students’ perception and awareness of cancer survivorship-related issues, advocating the value on introducing highly prevalent cancer survivorship topics early to both undergraduate STEM and non-STEM students.
Rock characteristics and reservoir properties of Upper Carboniferous (Stephanian A–B) tight siliciclastic rocks from the Saar–Nahe basin (SW Germany)
Authors: Quandt Dennis , Busch Benjamin , Greve Jonas , Hilgers Christoph 
Published: March 2024

AbstractThe environmental consequences of mine flooding in the Saar hard coal district, post-mining re-use concepts in the course of the energy transition, and the potential of coalbed methane production require an understanding of subsurface rock properties on the microscale. In this study, mineralogy, microtexture, microstructure, porosity, permeability, and geochemistry of an Upper Carboniferous (Stephanian A–B) drill core recovered in the Saar–Nahe basin are quantified. Based on these data, the diagenetic history and reservoir quality are analyzed regarding mine flooding and coalbed methane potential. The feldspar-poor and igneous rock fragment-free siliciclastic rock succession shows multiple fining upward sequences deposited in a fluvial environment during the pre-volcanic syn-rift phase of the Variscan intramontane Saar–Nahe basin. Intercalated small-scale coarsening upward sequences are related to the floodplain where near-surface soft-sediment deformation and paleosol formation took place. Porosity (< 7%) of the tight siliciclastic rocks is mainly controlled by an interplay of authigenic microporous kaolinite, dissolution porosity, and quartz cement, whereas permeability (< 0.05 mD) shows no systematic variation with petrography. During burial, quartz cements preserved porosity by stabilizing the granular framework against mechanical compaction, while phyllosilicates were ductilely deformed reducing reservoir quality. Relative phyllosilicates and quartz contents and mean grain size are reliably inferred from SiO2/Al2O3 ratios (1.8–28.8), Ba (0.0108–0.0653 wt%), Rb (0.0024–0.0181 wt%), and Sr (0.0013–0.0086 wt%) concentrations measured with a portable x-ray fluorescence analyzer. Regarding coalbed methane production and mine flooding, sealing of cleats and heterogeneous subsurface rock properties due to dynamically changing depositional settings during the Late Carboniferous need to be considered.
Graphical abstract
Creep Versus Consolidation in Tunnelling Through Squeezing Ground—Part A: Basic Time Effects
Authors: Leone Thomas , Nordas Alexandros N. , Anagnostou Georgios 
Published: March 2024

AbstractAlthough squeezing ground may undergo rapid convergences following tunnel excavation, its behaviour is often markedly time dependent due to creep or consolidation. The effects of creep and consolidation on shield tunnelling are comparatively evaluated in two companion papers, with the aim of demonstrating their qualitative similarities and distinctive features. The present, first paper investigates the basic time effects, placing focus on the time development of ground deformations and the complex interaction between ground, tunnel boring machine (TBM) and tunnel support during excavation and during construction standstills. The presented numerical simulations indicate several qualitative similarities between the two mechanisms of time dependency, in respect of the time development of ground deformations, the counter-intuitive behaviour of increasing shield loading with increasing rate of advance under certain conditions, as well as the thoroughly adverse effect of the additional time-dependent deformations taking place during construction standstills on the shield loading. However, they also underscore two prominent differences resulting from the fundamentally different nature of creep (a purely mechanical rheological process) and consolidation (a coupled hydromechanical process): first, the consistently more extensive plastic yielding in consolidating ground, which is partially associated with the seepage forces exerted by the pore water on the solid rock constituents. Second, the role of seepage forces as a potential destabilising agent, particularly for the tunnel face, which does not happen in the case of creep and may be critical for shield and cutterhead jamming. Building upon these investigations, the companion paper compares creep and consolidation with respect to the transferability of experiences about the required thrust force to tunnels of different diameter or to adjacent tunnels.
Association between enthesitis/dactylitis resolution and patient-reported outcomes in guselkumab-treated patients with psoriatic arthritis
Authors: Rahman Proton , McInnes Iain B. , Deodhar Atul , Schett Georg , Mease Phillip J. , Shawi May , Cua Daniel J. , Sherlock Jonathan P. , Kollmeier Alexa P. , Xu Xie L. , Sheng Shihong , Ritchlin Christopher T. , McGonagle Dennis 
Published: March 2024

Abstract
Objectives
To evaluate the association between enthesitis resolution (ER) and dactylitis resolution (DR) and meaningful improvements in patient-reported outcomes (PROs) among biologic-naïve patients with PsA receiving guselkumab in the DISCOVER-2 study.

Methods
Enthesitis and dactylitis, characteristic lesions of PsA, were evaluated by independent assessors using the Leeds Enthesitis Index (range, 0–6) and Dactylitis Severity Score (range, 0–60). Proportions of patients with ER or DR (score = 0) among those with score > 0 at baseline were determined at weeks 24, 52, and 100. PROs included: fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue [FACIT-Fatigue]), pain (0–100 visual analog scale), physical function (Health Assessment Questionnaire-Disability Index [HAQ-DI]), and health-related quality of life (36-item Short-Form Health Survey physical/mental component summary [SF-36 PCS/MCS]). Meaningful responses were defined as: improvements of ≥ 4 for FACIT-Fatigue, ≥ 0.35 for HAQ-DI, and ≥ 5 for SF-36 PCS/MCS and absolute scores of ≤ 15 for minimal pain and ≤ 0.5 for normalized HAQ-DI. Associations between ER/DR status and PRO response status were tested using a Chi-square test.

Results
Guselkumab-treated patients with ER were more likely than those without ER to achieve minimal pain (p < 0.001), normalized HAQ-DI (p < 0.001), and PCS response (p < 0.05) at weeks 24, 52, and 100. Patients with DR were more likely than those without DR to achieve FACIT-Fatigue response at week 24 and week 52 (both p ≤ 0.01) and minimal pain at week 24 and normalized HAQ-DI at week 52 (both p ≤ 0.03).

Conclusion
In biologic-naïve patients with active PsA treated with guselkumab, achieving ER or DR was associated with durable improvements in selected PROs, including those of high importance to patients.

Trial registration
ClinicalTrials.gov (https://clinicaltrials.gov) NCT03158285; Registered: May 16, 2017.

Key Points

• At week 100, 65% and 76% of guselkumab-treated patients achieved enthesitis and dactylitis resolution (ER/DR).• Achieving ER was associated with achieving DR and vice versa through the end of study.• Achieving ER or DR was associated with durable and meaningful improvements in selected patient-reported outcomes.
The Chvátal–Gomory procedure for integer SDPs with applications in combinatorial optimization
Authors: de Meijer Frank , Sotirov Renata 
Published: March 2024

Abstract
In this paper we study the well-known Chvátal–Gomory (CG) procedure for the class of integer semidefinite programs (ISDPs). We prove several results regarding the hierarchy of relaxations obtained by iterating this procedure. We also study different formulations of the elementary closure of spectrahedra. A polyhedral description of the elementary closure for a specific type of spectrahedra is derived by exploiting total dual integrality for SDPs. Moreover, we show how to exploit (strengthened) CG cuts in a branch-and-cut framework for ISDPs. Different from existing algorithms in the literature, the separation routine in our approach exploits both the semidefinite and the integrality constraints. We provide separation routines for several common classes of binary SDPs resulting from combinatorial optimization problems. In the second part of the paper we present a comprehensive application of our approach to the quadratic traveling salesman problem (QTSP). Based on the algebraic connectivity of the directed Hamiltonian cycle, two ISDPs that model the QTSP are introduced. We show that the CG cuts resulting from these formulations contain several well-known families of cutting planes. Numerical results illustrate the practical strength of the CG cuts in our branch-and-cut algorithm, which outperforms alternative ISDP solvers and is able to solve large QTSP instances to optimality.