bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncertain tone and SEO underpricing: Do financial constraints matter?
Authors: Ngo Anh , Lewis Thomas , McGowan Carl 
Published: March 2024

AbstractIn this study, we conduct several empirical tests to explore the role of financial constraints in predicting the underpricing of seasoned equity offerings (SEO underpricing) through the uncertain tone in issuing firms' filings. We show that investors can infer the firm quality or fundamental value when facing information uncertainty or value ambiguity for only firms in financially distressed groups. Our findings are consistent with prior studies using textual analysis that postulate the varying predictive power of different textual tones for the value of new seasoned equity offerings and, thus, SEO underpricing.
Determining the MMPI‐3 SUI scale's cross‐sectional and prospective utility in suicide risk assessment
Authors: Morris Cole S. , Keen Megan A. , White Chloe , Ingram Paul B. , Mitchell Sean M. , Victor Sarah E. 
Published: March 2024

AbstractObjectiveIn‐depth suicide risk assessments are particularly important to long‐term suicide prevention. Broadband measures of psychopathology, such as the Minnesota Multiphasic Personality Inventory (MMPI) instruments, assess suicide risk factors and various mental health comorbidities. With the recent release of the MMPI‐3, the Suicidal/Death Ideation (SUI) scale underwent revisions to improve its construct validity and detection of suicide risk factors. Thus, we hypothesized the MMPI‐3 SUI scale would demonstrate medium to large associations with suicidal experience and behaviors, future ideation, and interpersonal risk factors of suicide.MethodsA sample of 124 college students screened for elevated depressive symptoms completed a brief longitudinal study. Participants completed a baseline session including the MMPI‐3 and criterion measures and three brief follow‐ups every 2 weeks.ResultsSUI scores were most robustly associated with increased risk for past suicidal ideation, planning, and perceived burdensomeness. Prospectively assessed suicidal ideation was also meaningfully associated with SUI. SUI scale elevations indicate an increased risk of suicide‐related risk factors.ConclusionThe MMPI‐3 is a valuable tool to inform long‐term suicide prevention for those experiencing elevated depressive symptoms as the SUI scale can assess past, current, and future suicide‐related risk factors, including suicidal ideation and behaviors.
Running a successful STEMM summer program: A week‐by‐week guide
Authors: Beasley Heather K. , Vue Zer , McReynolds Melanie R. , Garza‐Lopez Edgar , Neikirk Kit , Mungai Margaret , Marshall Andrea G. , Shao Bryanna , Benjamin Jazmine I. , Wanjalla Celestine N. , Williams Clintoria R. , Murray Sandra A. , Jordan Valerie K. , Shuler Haysetta D. , Kirabo Annet , Hinton Antentor 
Published: March 2024

AbstractWhile some established undergraduate summer programs are effective across many institutions, these programs may only be available to some principal investigators or may not fully address the diverse needs of incoming undergraduates. This article outlines a 10‐week science, technology, engineering, mathematics, and medicine (STEMM) education program designed to prepare undergraduate students for graduate school through a unique model incorporating mentoring dyads and triads, cultural exchanges, and diverse activities while emphasizing critical thinking, research skills, and cultural sensitivity. Specifically, we offer a straightforward and adaptable guide that we have used for mentoring undergraduate students in a laboratory focused on mitochondria and microscopy, but which may be customized for other disciplines. Key components include self‐guided projects, journal clubs, various weekly activities such as mindfulness training and laboratory techniques, and a focus on individual and cultural expression. Beyond this unique format, this 10‐week program also seeks to offer an intensive research program that emulates graduate‐level experiences, offering an immersive environment for personal and professional development, which has led to numerous achievements for past students, including publications and award‐winning posters.
Enhancing malignancy prediction in thyroid nodules: A multimodal ultrasound radiomics approach in TI‐RADS category 4 lesions
Authors: Li Jian , Li Siyao , Zhou Wang , Duan Yayang , Zheng Hui 
Published: March 2024

AbstractPurposeTo explore the diagnostic value of intralesional and perilesional radiomics based on multimodal ultrasound (US) images in predicting the malignant ACR TIRADS 4 thyroid nodules (TNs).MethodsA total of 297 cases of TNs in patients who underwent preoperative thyroid grayscale US and shear wave elastography (STE) were enrolled (training cohort: n = 150, internal validation cohort: n = 77, external validation cohort: n = 70). Regions of interests (ROIs) were delineated on grayscale US images and STE images, and then an isotropic expansion of 1.0, 1.5, 2.0, 2.5, and 3.0 mm was applied. Predictive models were established using recursive feature elimination‐support vector machines (RFE‐SVM) based on radiomics features calculated by random forest.ResultsThe perilesional ROI1.5mm expansion achieved the highest area under curve (AUC) (AUC: 0.753 for grayscale US, 0.728 for STE; 95% confidence interval (CI): 0.664–0.743, 0.684–0.739, respectively). The joint model had the highest AUC values of 0.936 in the training dataset, 0.926 in internal dataset, and 0.893 in external dataset. The calibration curve showed good consistency and the decision curve indicated a greater clinical net benefit of the joint model.ConclusionJoint model containing perilesional radiomics (1.5 mm) had significant value in predicting the malignant ACR TIRADS 4 TNs.
Exploring the incidence of peripheral arterial occlusive disease following COVID‐19 infection: A retrospective cohort study
Authors: Yeh Liang‐Tsai , Chan Chi‐Ho , Wang Yu‐Hsun , Lee Chia‐Yi , Yang Shun‐Fa , Yeh Chao‐Bin 
Published: March 2024

AbstractPeripheral arterial occlusive disease (PAOD) is a clinical manifestation of systemic atherosclerosis and is always associated with cerebrovascular disease and various complications. The aim of our study is to evaluate the relationship between the coronavirus disease 2019 (COVID‐19) infection and the subsequent PAOD development. A retrospective cohort study was conducted and individuals with COVID‐19 infection were identified from the TriNetX analytics platform. A total of 2 206 065 patients with COVID‐19 infection and 2 206 065 patients without COVID‐19 infection were recruited after exclusion and matching. The primary outcome was the development of PAOD after the COVID‐19 infection. The Cox proportional hazard regression was adopted to yield the hazard ratio (HR) and 95% confidence interval (CI) of PAOD between groups. After the whole follow‐up period, the incidence of PAOD was significantly higher in the COVID‐19 group at both the 3‐month follow‐up (HR: 1.27, 95% CI: 1.24–1.30) and the 12‐month follow‐up (HR: 1.33, 95% CI: 1.31–1.35) The Kaplan‐Meier analysis with the log‐rank test demonstrated a higher cumulative probability of PAOD in the COVID‐19 group compared to the non‐COVID‐19 group (p < 0.001). In stratified analysis using 65 years as the threshold, both age groups in the COVID‐19 group exhibited a higher risk of PAOD. Similarly, in the sex and race stratified analysis, the COVID‐19 group performed a higher risk of PAOD in both subgroups. In conclusion, the COVID‐19 infections are strongly associated with an increment of PAOD incidence.
Strategic alliances and social performance of microfinance institutions in Indonesia
Authors: Kore Morrison Hendrik Riwu , Rokhim Rofikoh , Rahmawati Riani , Sudhartio Lily 
Published: March 2024

AbstractThe objective of this study is to understand how strategic alliances and dynamic capabilities influence the performance of microfinance institutions (MFIs) in Indonesia. The research was conducted on a sample of 235 CEOs/top leaders of MFIs spread across all provinces in Indonesia. Data collection used survey questionnaires. Data testing used SPSS version 25, and structural modeling used Amos version 25. The findings show that strategic alliances significantly influence dynamic capabilities and dynamic capabilities significantly influence social performance. Social performance has a significant effect on financial performance. MFIs are important in establishing strategic alliance and strengthening their dynamic capabilities to improve social performance (depth and breadth of reach) and affect financial performance. Social performance includes the depth of the reach to contribute to improving the quality of life of people experiencing poverty around the MFI's operations and the social responsibility of MFIs to the community through scholarships, free medical assistance, basic food assistance, and building/renovating houses of worship and others.
High‐Temperature X‐Ray Imaging with Transparent Ceramics Scintillators
Authors: Wang Ting , Hu Song , Ji Tao , Zhu Xuanyu , Zeng Guoqiang , Huang Ling , Yakovlev Alexey Nikolaevich , Qiu Jianbei , Xu Xuhui , Yu Xue 
Published: March 2024

AbstractScintillators with high spatial‐resolution and high‐stability are highly desirable for X‐ray imaging applications at unpredictable environments. To challenge state‐of‐the‐art technology, it is necessary to design high thermal stable scintillators with high‐resolution and high light yield. In this work, the zero‐thermal‐quenching Lu3Al5O12:Ce3+ (LuAG: Ce3+) transparent ceramics (TCs) is synthesized with high optical transparency. The thermoluminescence (TL) curves of the as‐obtained TCs demonstrate that the formation of the oxygen vacancies, acting as the trapping centers, can capture the carriers and then contribute to the enhancement of its thermals stability via the thermal compensation effect. The exceptional thermal‐stability of the TCs scintillator endows the monitoring of the dynamic changes of the internal structure of the objective samples without any ghosting effects during heating. In addition, given the ultra‐high uniform, transparency, and fast light decay of the TCs scintillator, the excellent spatial resolution (≈112 lp mm−1) of the X‐ray microscopic imaging is realized. These results undeniably demonstrate that the as‐obtained LuAG: Ce3+ TCs have great prospects for advancement in X‐ray detectors.
3D Inkjet Printing of Biomaterials with Solvent‐Free, Thiol‐Yne‐Based Photocurable Inks
Authors: Kainz Michael , Haudum Stephan , Guillén Elena , Brüggemann Oliver , Höller Rita , Frommwald Heike , Dehne Tilo , Sittinger Michael , Tupe Disha , Major Zoltan , Stubauer Gerald , Griesser Thomas , Teasdale Ian 
Published: March 2024

Abstract3D inkjet printing is a fast, reliable, and non‐contact bottom–up approach to printing small and large models and is one of the fastest additive manufacturing technologies available. These attributes position inkjet printing as a promising tool for the additive manufacturing of biomaterials, for example, tissue engineering scaffolds. However, due to the stringent technical rheological requirements of current inkjet technologies, there is a lack of photopolymer resins suitable for the inkjet printing of biomaterials. Hence, a novel ink engineered for 3D piezoelectric inkjet printing of biomaterials is designed and developed. The novel resin leverages a biodegradable amino acid phosphorodiamidate matrix copolymerized with a dialkyne ether to modulate the viscosity. Copolymerization with commercially available thiols facilitates the photochemical thiol‐yne curing reaction. The ink exhibits optimal viscosity, eliminating the need for solvents, as well as reliable jetting and sufficiently swift curing kinetics. Furthermore, the formulation is successfully demonstrated in an industrial inkjet printhead. Notably, the resulting materials have low cytotoxicity and, hence, have significant promise in advancing the applications of 3D inkjet printing of biological scaffolds.
Tertiary lymphoid structures in cancer: immune mechanisms and clinical implications
Authors: Wang Siyu , Wang Hua , Li Chenbei , Liu Binfeng , He Shasha , Tu Chao 
Published: March 2024

AbstractCancer is a major cause of death globally, and traditional treatments often have limited efficacy and adverse effects. Immunotherapy has shown promise in various malignancies but is less effective in tumors with low immunogenicity or immunosuppressive microenvironment, especially sarcomas. Tertiary lymphoid structures (TLSs) have been associated with a favorable response to immunotherapy and improved survival in cancer patients. However, the immunological mechanisms and clinical significance of TLS in malignant tumors are not fully understood. In this review, we elucidate the composition, neogenesis, and immune characteristics of TLS in tumors, as well as the inflammatory response in cancer development. An in‐depth discussion of the unique immune characteristics of TLSs in lung cancer, breast cancer, melanoma, and soft tissue sarcomas will be presented. Additionally, the therapeutic implications of TLS, including its role as a marker of therapeutic response and prognosis, and strategies to promote TLS formation and maturation will be explored. Overall, we aim to provide a comprehensive understanding of the role of TLS in the tumor immune microenvironment and suggest potential interventions for cancer treatment.
A pilot trial of neoadjuvant pyrotinib plus trastuzumab, dalpiciclib, and letrozole for triple‐positive breast cancer
Authors: Huo Shiwen , Xue Jinqi , Wang Shuo , Shan Huilian , Chen Guanglei , Niu Nan , Wang Yimin , Qiu Fang , Zhao Yi , Xing Fei , Zheng Xinyu , Tu Wei , Li Ke , Zhao Hai , Tang Meiyue , Xu Qianshi , Liu Chao , Zhao Yafei , Jiang Xiaofan , Pang Zheng , Zhang Keliang , Zhang Dianlong , Chen Zhe‐Sheng , Liu Caigang 
Published: March 2024

AbstractTriple‐positive breast cancer (TPBC) poorly responds to current standard neoadjuvant therapy (trastuzumab plus pertuzumab and chemotherapy). Our previous MUKDEN 01 study showed a promising total pathological complete response (tpCR) rate of 30.4% with neoadjuvant pyrotinib (pan‐human epidermal growth factor receptor tyrosine kinase inhibitor) plus dalpiciclib (cyclin‐dependent kinase 4/6 inhibitor) and letrozole, but the efficacy remains suboptimal. This pilot study (NCT05228951) explored adding trastuzumab to this triplet neoadjuvant regimen in patients with stage II–III TPBC. The primary endpoint was tpCR (ypT0/is, ypN0) rate. Between February 2022 and June 2022, 12 patients were enrolled, and seven (58%; 95% confidence interval [CI], 27.7%–84.8%) patients achieved tpCR. The rate of residual cancer burden (RCB) 0–I was 75% (95% CI, 46.8%–91.1%). The objective response rate (ORR) was 92% (95% CI, 64.6%–98.5%). Mean Ki‐67 level was significantly reduced from 45.0% (95% CI, 19.5%–70.5%) at baseline to 17.2% (95% CI, 0.7%–33.7%) after neoadjuvant therapy (p = 0.03). The most common grade 3 adverse events were diarrhea (four [33%]) and decreased neutrophil count (three [25%]). No grade 4 adverse events or treatment‐related deaths occurred. This four‐drug neoadjuvant regimen shows promising pathological response with an acceptable safety profile in patients with TPBC. A randomized controlled trial (NCT05638594) of this regimen is being conducted.
Prevalence of Duffy null and its impact on hydroxyurea in young children with sickle cell disease in the United States
Authors: Oladipupo Fathia , Stanek Joseph , Walden Joseph , Young Jennifer , Rose Melissa J. , Nicol Kathleen , Villella Anthony , Creary Susan 
Published: March 2024

AbstractConsistent with studies showing a high prevalence of the Duffy null phenotype among healthy Black Americans, this retrospective study found that Duffy null was present in >75% of a young and contemporary cohort of children with sickle cell disease (SCD) in the United States. Despite the potential for this phenotype to impact absolute neutrophil counts, hydroxyurea (HU) dosing, and outcomes, it was not associated with being prescribed a lower HU dose or having increased acute SCD visits early in the HU treatment course. Future studies are needed to confirm these findings in older children with SCD.
Interfacial strengthening and processing of carbon fibers reinforced poly(ether‐ether‐ketone) composites: A mini‐review
Authors: Dang Jing , Sun Jiayi , Liu Zheng 
Published: March 2024

AbstractCarbon fibers/poly(ether‐ether‐ketone) (CF/PEEK) composites have the advantages of excellent impact resistance, good moisture and heat resistance, ultra‐short molding cycle and recyclable secondary processing. Therefore, the investigation on CF/PEEK composites is an important development direction of low‐cost and high‐performance polymer‐based composites. However, due to the strong surface inertness of CF and the poor interface compatibility between CF and PEEK matrix, the mechanical properties of CF/PEEK composites are low. Moreover, PEEK matrix has the high melting point and large viscosity, making the processing of CF/PEEK composites very difficult. In this paper, the factors affecting the interfacial properties of CF/PEEK composites, the surface functionalization modification methods of CF, and the design & synthesis of interfacial compatibilizer are reviewed. The research progress and related academic achievements in interfacial strengthening and additive manufacturing technology of CF/PEEK composites are emphatically discussed. Finally, the development trends and application prospects of CF/PEEK composites are summarized.Highlights
CF/PEEK composite is the key material for industry and infrastructure.
The factors affecting the interface interaction between PEEK and CF.
The methods of interface strengthening for CF/PEEK composites.
The additive manufacturing technology of CF/PEEK composites.
The development trends and application of CF/PEEK composites.
Combination of large‐volume sample stacking with polarity switching and micelle electrokinetic chromatography for the analysis of anion compounds in Yangxinshi tablets
Authors: Liu Wenping , Zhou Rui , Li Jin , Du Kunze , He Jun , Yao Yaqi , Chang Yanxu 
Published: March 2024

AbstractIntroductionYangxinshi tablet (YXST) is a traditional Chinese medicine preparation characterized by its high efficacy and safety for the treatment of cardiovascular diseases. Anionic compounds have been revealed as potential active components. However, there is currently limited research regarding its quality control.ObjectiveWe aimed to establish a strategy for the simultaneous separation and determination of five key anionic compounds in YXST.MethodA sensitive and efficient analytical method was developed and applied for the simultaneous separation and determination of five key compounds in YXST using large‐volume sample stacking with polarity switching and micelle electrokinetic chromatography (LVSS‐PS‐MEKC) coupled with diode array detection. Crucial parameters, including sample volume, applied voltage, composition and pH of the running buffer, concentration of organic modifier, and switching time of the polarity, were systematically evaluated and optimized using a single variable method to enhance separation performance. Furthermore, the impact of cyclodextrin and sodium dodecyl sulfate as electrolyte modifiers was also investigated.ResultsUnder the optimal conditions, baseline separation of the five compounds (daidzein, puerarin, glycyrrhiztinic acid, chlorogenic acid, and salvianolic acid B) was achieved within 20 min. In comparison to the conventional MEKC mode, the constructed LVSS‐PS‐MEKC method exhibited a more than sixfold increase in the enrichment factor. The method was validated in terms of linearity, precision, accuracy, 24 h stability, and recovery and successfully applied to analyze YXST samples.ConclusionA sensitive strategy was developed for the simultaneous separation and determination of five key anionic components in YXST, offering a robust and efficient strategy for pharmaceutical analysis.
Front Cover Image
Authors: Yang Fan , Wang Pan , Zheng Min , Hou Xiao‐Yu , Zhou Li‐Lin , Wang Yong , Si Sheng‐Yun , Wang Xiao‐Ping , Chapman Jason W. , Wang Yu‐Meng , Hu Gao 
Published: March 2024

The cover image is based on the Research Article Physiological and behavioral basis of diamondback moth Plutella xylostella migration and its association with heat stress by Fan Yang et al., https://doi.org/10.1002/ps.7904.image
Deep‐NCA: A deep learning methodology for performing noncompartmental analysis of pharmacokinetic data
Authors: Liu Gengbo , Brooks Logan , Canty John , Lu Dan , Jin Jin Y. , Lu James 
Published: March 2024

AbstractNoncompartmental analysis (NCA) is a model‐independent approach for assessing pharmacokinetics (PKs). Although the existing NCA algorithms are very well‐established and widely utilized, they suffer from low accuracies in the setting of sparse PK samples. In response, we developed Deep‐NCA, a deep learning (DL) model to improve the prediction of key noncompartmental PK parameters. Our methodology utilizes synthetic PK data for model training and uses an innovative patient‐specific normalization method for data preprocessing. Deep‐NCA demonstrated adequate performance across six previously unseen simulated drugs under multiple dosing, showcasing effective generalization. Compared to traditional NCA, Deep‐NCA exhibited superior performance for sparse PK data. This study advances the application of DL to PK studies and introduces an effective method for handling sparse PK data. With further validation and refinement, Deep‐NCA could significantly enhance the efficiency of drug development by providing more accurate NCA estimates while requiring fewer PK samples.
Safety of inhaled nitric oxide withdrawal in severe chronic pulmonary hypertension
Authors: Pérez‐Peñate Gregorio Miguel , Juliá‐Serdá Gabriel , Galván‐Fernández Helena , Alemán‐Segura Desireé , León‐Marrero Fernando , Garcia‐Quintana Antonio , de Larrinoa Iñigo Rúa‐Fernández , Ortega‐Trujillo José Ramón , Gómez‐Sánchez Miguel Ángel 
Published: March 2024

AbstractInhaled nitric oxide (iNO) is a potent and selective pulmonary vasodilator with a safety concern due to rebound pulmonary hypertension (PH) associated with its withdrawal. We report short‐term pulsed iNO in patients with severe pulmonary arterial hypertension (PAH) and nonoperable chronic thromboembolic PH (nCTEPH). This is a retrospective analysis of 33 patients: 22 with PAH and 11 with nCTEPH. We assessed hemodynamic, echocardiographic, and other noninvasive variables to evaluate safety and efficacy of iNO. We performed an iNO withdrawal test during right heart catheterization and after 3 days of iNO treatment. iNO significantly improved all variables examined in 22 patients with PAH and 11 with nCTEPH. Two patterns of response were observed after sudden iNO withdrawal. Twenty‐nine patients (88%) showed minimal hemodynamic, oxygenation and clinical changes. Four patients (12%) had a reduction in cardiac index ≥20% and PaO2 ≥ 5%, three patients did not show clinical deterioration, and one patient developed hemodynamic collapse that needed iNO administration. This retrospective study suggests that short‐term iNO improves hemodynamics and clinical conditions in some patients with PAH an nCTPEH. However, pulsed iNO withdrawal PH rebound could be a serious concern in these patients. Given the lack of evidence, we do not recommend the use of pulsed iNO in the treatment of patients with chronic PH.