bluuebunny/crossref_metadata_2025_split huggingface dataset:
Childhood adversity and psychopathology: the dimensions of timing, type and chronicity in a population-based sample of high-risk adolescents
Authors: Zarchev Milan , Grootendorst-van Mil Nina H. , Bouter Diandra C. , Hoogendijk Witte J. G. , Mulder Cornelis L. , Kamperman Astrid M. 
Published: March 2024

Abstract
Background
Research on childhood adversity and psychopathology has begun investigating the dimension of timing, however the results have been contradictory depending on the study population, outcome and how adverse life events (ALEs) were operationalized. Additionally, studies so far typically focus only on a narrow range of psychiatric diagnoses or symptoms. The current cross-sectional study aimed to examine the association between timing, type and chronicity of ALEs and adolescent mental health problems.

Methods
Adolescents from a population-based cohort oversampled on emotional and behavioral problems (mean age 14.8; range 12–17, N = 861) were included in the current analysis. Primary caregivers were interviewed on what ALEs adolescents experienced. ALEs were defined in two ways: (1) broad operationalization, including school difficulties, parental divorce, and family sickness; and (2) physically threatening abuse only, including physical and sexual violence. After looking at lifetime ALEs, we turned to chronicity, timing and sex differences. We focused on overall psychiatric symptoms as well as specific domains of emotional and behavioral problems, assessed using the Youth Self Report (YSR) and psychotic experiences assessed using the Prodromal Questionnaire-16 (PQ-16). A series of linear models adjusted for sociodemographic and parental factors were used.

Results
Lifetime ALEs were associated with all types of psychopathology, with relatively bigger effect sizes for broad than for physical ALEs. The latter associations were found to be more robust to unmeasured confounding. The 9–12 age period of experiencing both broad and physical ALE’s was most saliently associated with any psychopathology. Girls were more at risk after experiencing any ALEs, especially if the adversity was chronic or ALEs took place after the age of 12.

Conclusions
Broad as well as physical ALEs are associated with psychopathology, especially ALEs experienced during the 9–12 age period. Physical ALEs may be more useful in investigating specific etiological factors than broad ALEs. Sex differences may not emerge in lifetime measures of ALEs, but can be important for chronic and later childhood adversity.
Iso-mukaadial acetate and ursolic acid acetate bind to Plasmodium Falciparum heat shock protein 70: towards targeting parasite protein folding pathway
Authors: Opoku Francis , Govender Penny , Shonhai Addmore , Simelane Mthokozisi BC 
Published: March 2024

AbstractPlasmodium falciparum is the most lethal malaria parasite. P. falciparum Hsp70 (PfHsp70) is an essential molecular chaperone (facilitates protein folding) and is deemed a prospective antimalarial drug target. The present study investigates the binding capabilities of select plant derivatives, iso-mukaadial acetate (IMA) and ursolic acid acetate (UAA), against P. falciparum using an in silico docking approach. The interaction between the ligands and PfHsp70 was evaluated using plasmon resonance (SPR) analysis. Molecular docking, binding free energy analysis and molecular dynamics simulations were conducted towards understanding the mechanisms by which the compounds bind to PfHsp70. The molecular docking results revealed ligand flexibilities, conformations and positions of key amino acid residues and protein-ligand interactions as crucial factors accounting for selective inhibition of Hsp70. The simulation results also suggest protein-ligand van der Waals forces as the driving force guiding the interaction of these compounds with PfHsp70. Of the two compounds, UAA and IMA bound to PfHsp70 within the micromolar range based on surface plasmon resonance (SPR) based binding assay. Our findings pave way for future rational design of new selective compounds targeting PfHsp70.
Two stents’ dislodgement in the left main coronary artery: a case report
Authors: Arous Salim , Zahidi Hatim , El Ghali Benouna Mohamed , Habbal Rachida 
Published: March 2024

Abstract
Background
Stent dislodgement is a life-threatening complication that can result in coronary artery embolization, stent thrombosis, acute myocardial infarction, and even death. Severely angulated, heavily calcified, and previously stented coronary arteries are associated risk factors. With the development of different lesion preparation techniques and the drug eluting stent era, the reported incidence of stent dislodgement has decreased to < 1% in the last few years.

Case presentation
We report a case of a 64-year-old Moroccan man complicated during percutaneous intervention in the left main artery by the loss of two stents. This complication was successfully managed by passing the stent’s balloon into the stent and then fully expanding it. In our case, the device’s characteristics were involved and could play a role in such complications, but it is still not well understood.

Conclusions
The main treatment option is stent retrieval with different available techniques. If retrieval of the stent is impossible, crushing it against the blood vessel wall could be considered.
Oak leaf morphology may be more strongly shaped by climate than by phylogeny
Authors: Martín-Sánchez Rubén , Sancho-Knapik Domingo , Alonso-Forn David , López-Ballesteros Ana , Ferrio Juan Pedro , Hipp Andrew L. , Peguero-Pina José Javier , Gil-Pelegrín Eustaquio 
Published: March 2024

Abstract
Key message
Despite been grown under the same climate, oak species are able to correlate with looser, but still identifiable, leaf morphological syndromes, composed by morphological traits with an ecological role in their respective macroclimates.

Context
Environmental restrictions imposed by climate have been shown to modulate leaf morphology. A reduction of leaf area in hot and dry climates reduces overheating because of a thinner boundary layer. Lobed shapes enhance hydraulic conductivity and faster cooling. Elongated leaves drain more quickly under high precipitation. Trichomes may help to reduce the effects of excessive sun exposure in hot and dry environments. Leaf mass per area (LMA) increases in stressful environments.

Aim
To assess the influence of global climate and clade on oak leaf syndromes comprising morphological traits with ecological roles.

Methods
We analyzed seven morphological traits in 141 oak species grown in a botanical garden, characterized into five macroclimates, and explored the partial effects of clade and climate.

Results
We found significant associations between macroclimate and every morphological trait measured. Temperate species tend to have large, obovate, lobed, malacophyllous leaves. Species occurring in dry habitats usually present small, rounded, pubescent, sclerophyllous leaves. Warm and wet climates induce the development of slender, lanceolate, glabrous leaves with an acuminate apex.

Conclusion
The functional roles of the different morphological traits are partially confirmed in genus Quercus as a response to the different macroclimates, where different leaf syndromes can be distinguished.
Appropriate Prescribing for older adults with Multimorbidity (Pro-M): protocol for a feasibility study
Authors: Tang Jia Ying , Teng Poh Hoon June , Chen Christine Yuanxin , Tan Keng Teng , Ang Wendy , Lau Sabrina , Ang Alexis Guat Cheng , Kyaw Kay Khine , Tay Xin Yong , Lim Wan Min Stephanie , Espeleta Wrenzie Del Valle , Lin Huimin , Ding Yew Yoong , Lun Penny 
Published: March 2024

Abstract
Background
Potentially inappropriate prescribing is common among older adults with multimorbidity due to various reasons, from concurrent application of multiple single-disease clinical guidelines to fragmentation of care. Interventions such as medication review have been implemented worldwide to reduce inappropriate prescribing for older adults. However, the implementability of such interventions are underexplored in the outpatient clinics in Singapore’s public hospitals. Hence, the Pro-M study aims to assess the feasibility of implementing a physician-pharmacist collaborative care intervention in geriatric medicine outpatient clinics to facilitate appropriate prescribing for older adults in Singapore.

Methods
This is a single-arm, non-randomised feasibility study using a pre-post evaluation design. This study consists of two parts: (1) implementation phase of the intervention (6 months) and an (2) evaluation phase (3 months). Eligible patients will be recruited from geriatric medicine outpatient clinics at two public hospitals in Singapore through convenience sampling. The main components of the Pro-M intervention are: (1) pharmacist-facilitated medication reviews with feedback on any medication issues and potential recommendations to physicians, and (2) physicians communicating changes to other relevant prescribers. The evaluation phase will involve surveying and interviewing physicians and pharmacists involved in the implementation of the intervention. A mixed-method approach will be employed for data collection and analysis. The quantitative and qualitative findings will be triangulated and reported using Proctor’s implementation outcomes: appropriateness, penetration, acceptability, fidelity, feasibility, and sustainability. A basic cost analysis will be conducted alongside the study.

Discussion
This is a phase 2 study to test the feasibility of implementing an intervention that was co-created with stakeholders during phase 1 development of an intervention to optimise prescribing for older adults with multimorbidity. The implementation will be assessed using Proctor’s implementation outcomes to provide insights on the process and the feasibility of implementing medication reviews for older adults with multimorbidity as a routine practice in outpatient clinics. Data collected from this study will inform a subsequent scale-up study.

Trial registration
ClinicalTrials.gov Identifier: NCT05756478. Registered on 06 March 2023.
The efficacy and safety of cannabidiol (CBD) in pediatric patients with Dravet Syndrome: a narrative review of clinical trials
Authors: Aderinto Nicholas , Olatunji Gbolahan , Kokori Emmanuel , Ajayi Yusuf Ismaila , Akinmoju Olumide , Ayedun Abiola Samuel , Ayoola Oluwapelumi Ikeoluwa , Aderinto Noah Oluwaseun 
Published: March 2024

Abstract
Background
Dravet Syndrome (DS) is a rare and severe form of childhood epilepsy that is often refractory to conventional antiepileptic drugs. Emerging evidence suggests that Cannabidiol (CBD) offer therapeutic benefits for DS. This review aims to evaluate the efficacy and safety of CBD in pediatric patients with DS based on data from ten clinical trials.

Methods
A review was conducted to identify clinical trials assessing the efficacy and safety of CBD in pediatric patients diagnosed with DS. PubMed, MEDLINE, Scopus, Web of Science, and relevant grey literature were systematically searched for relevant articles up to October 2023, and clinical trials within the last 10 years were included. The search strategy incorporated controlled vocabulary terms and keywords related to "Cannabidiol," "Dravet Syndrome," and "pediatric patients."

Results
The analysis revealed promising efficacy outcomes. Notably, CBD demonstrated substantial reductions in seizure frequency, with some patients achieving seizure freedom. The findings emphasised the consistency of CBD's efficacy across different patient subgroups. The safety profile of CBD was generally acceptable, with adverse events often being manageable.

Conclusion
This review consolidates evidence from multiple clinical trials, affirming the potential of CBD as a promising treatment option for pediatric patients with DS. While further research is needed to address existing knowledge gaps, CBD's efficacy and acceptable safety profile make it a valuable addition to the therapeutic tools for DS.
Dietary patterns in relation to glioma: a case–control study
Authors: Nemati Mohammad , Shayanfar Mehdi , Almasi Fatemeh , Mohammad-Shirazi Minoo , Sharifi Giuve , Aminianfar Azadeh , Esmaillzadeh Ahmad 
Published: March 2024

AbstractAlthough the association of individual foods and nutrients with glioma have been investigated, studies on the association of major dietary patterns and glioma are scarce. The aim of this study was to examine the association between major dietary patterns and risk of glioma in a group of Iranian adults. In this hospital-based case–control design, we recruited 128 newly diagnosed glioma cases and 256 controls in Tehran from 2009 to 2011. A Willett-format-validated 126-item semi-quantitative Food Frequency Questionnaire (FFQ) was used to assess participants' dietary intake. Factor analysis was used to identify major dietary patterns. We identified 3 major dietary patterns using factor analysis: high protein, vegetarian and western dietary pattern. After several adjustments for potential confounders, adherence to the high protein dietary pattern was inversely associated with risk of glioma (OR: 0.47; 95% CI: 0.23, 0.95). Consumption of vegetarian dietary pattern was also associated with a reduced risk of glioma (OR: 0.16; 95% CI: 0.07, 0.34). Greater adherence to the western dietary pattern was associated with a greater chance of glioma (OR: 3.30; 95% CI: 1.52, 7.17). We found that high protein, vegetarian and western dietary pattern were significantly associated with glioma risk. Further prospective studies are needed to confirm these findings.
A longitudinal qualitative study on Iranian university lecturers' identity reconstruction during the COVID-19 pandemic through text-mining: a dynamic approach
Authors: Shobeiry Maria 
Published: March 2024

AbstractThis research addressed the critical gap in understanding the procedure of professional identity reconstruction among university lecturers in Iran during the pandemic. Over the course of two academic semesters, this study utilized a dynamic theoretical framework to investigate the intricacies of how 41 Iranian university English teachers reconstructed their professional identities. Data were collected through a dynamic methodological framework, comprising: semi-structured interviews conducted monthly, focus group interviews held every 3 months, and participants' reflective journal entries collected every 2 weeks. Text mining techniques and content analysis, through KH Coder 3.0, were employed to explore the nuanced aspects of teachers' identity reconstruction, focusing on contextual elements, agency, and pedagogical practices. The use of KH Coder 3.0 software for word co-occurrence and word association analysis revealed that university lecturers reconstructed their professional identities in response to the challenges posed by two main factors: (1) adapting to new educational contexts and (2) overcoming difficulties in teacher–student communication caused by the abrupt shift from traditional in-person education to online schooling. Through their practical experiences, educators emerged as proactive problem solvers, receptive adapters, and confident professionals. These findings carry implications for educational institutions and teacher educators, emphasizing the importance of prioritizing pedagogical systems that encourage teachers to excel in hybrid teaching contexts, fostering proficiency in online communication and virtual teaching methods.
Are changes in patient-reported outcomes prognostic for diffuse large B-Cell lymphoma survival? Results from the GOYA trial
Authors: Yan Jessie T. , Bel Célia , Trask Peter C. , Lo Ernest 
Published: March 2024

AbstractIn this hypothesis-generating analysis, we examined whether longitudinal changes in patient-reported outcomes (PROs), such as symptoms, over time would be prognostic for progression-free survival (PFS) and overall survival (OS) in patients with diffuse large B-cell lymphoma (DLBCL) who were newly treated with obinutuzumab (G) in combination with CHOP (G-CHOP) or rituximab (R) with CHOP (R-CHOP), in the GOYA Phase 3 trial (NCT01287741). Our results show that from the study baseline to cycle 3 day 1, every 1-point increase (worsening) in fever symptoms was associated with a 41% higher risk of death (hazard ratio [HR], 1.41; P = 0.01). Every 1-point increase (worsening) in lumps or swelling symptoms was associated with a 27% higher risk of disease progression or death (PFS events) (HR, 1.27; P = 0.01) and a 29% higher risk of death (OS events) (HR, 1.29; P = 0.02). No significant associations were observed between survival and changes in other symptoms, such as itching. Our study suggests that changes in some PROs are related to survival in DLBCL patients.
Concurrent spontaneous coronary dissection and reversible cerebral vasoconstriction syndrome during postnatal care
Authors: Yoon Sang Gon , Song Yeo-Jeong , Song Yun-Seok , Park Jino , Kim Seunghwan , Kim Dong-Kie , Kim Ki-Hun , Kim Doo-Il , Kim Hyun Kuk , Lee Dong Ah 
Published: March 2024

Abstract
Background
Pregnancy-associated spontaneous coronary artery dissection (SCAD) and reversible cerebral vasoconstriction syndrome (RCVS) are rare conditions that may occur during pregnancy and the postpartum period. The coexistence of both diseases may pose a risk to patients, potentially resulting in a variety of complications and clinical manifestations. This is considered the first case of a patient who successfully recovered from a critical condition in the postpartum period, with contemporaneous SCAD and RCVS.

Case presentation
A 33-year-old female with no known medical history was referred to the emergency department after experiencing cardiac arrest, which occurred 1 week after giving birth to her third child. She complained of sudden anterior squeezing chest pain, accompanied by a headache, and eventually collapsed due to ventricular fibrillation with seizure. She was successfully resuscitated after receiving basic life support. She showed an alert mentality and did not experience any further seizure events or additional neurological symptoms. Although vital sign remained stable, the level of highly sensitive troponin I was significantly elevated. Electrocardiography revealed sinus rhythm with T-wave inversion at V1-4, while chest computed tomography (CT) demonstrated severe aspiration pneumonia. The patient was admitted to the intensive care unit due to a high requirement of O2 supply. A consultation with the neurologic department and a brain magnetic resonance angiography (MRA) were conducted for the thunderclap headache. The brain MRA demonstrated stenosis in the basilar artery, the right M2 segment, and bilateral A1 segments, along with sulcal hyperintensity on post-contrast fluid-attenuated inversion recovery (FLAIR) suggesting blood–brain barrier breakdown due to vasoconstriction. Formal echocardiography showed regional wall motion abnormality in the left anterior descending artery (LAD) territory. After the improvement of pneumonia, a coronary angiography was performed, revealing diffuse luminal narrowing from the mid to distal LAD due to a long segmental, extensive dissection. We decided to maintain the medical therapy. A follow-up coronary CT angiography performed 6 months later revealed complete remission of the dissected coronary vessel, and a brain MRA checked 3 months later showed resolved vasoconstriction of the relevant cerebral vessels.

Conclusions
The physicians must be aware of pregnancy-associated complications in certain patients. Clear diagnoses and proper treatments are required in pregnant patients who may be exposed to multiple acute conditions, in order to reduce complications and achieve favorable outcomes.
Arytenoid adduction asymmetry among patients with laryngeal disorders
Authors: Bamigboye Babatunde Akinola , Akinola Moses Ayodele , Ogunbiyi Agboola Adebowale , Somefun Abayomi Oladapo 
Published: March 2024

Abstract
Background
Arytenoid asymmetry is usually an incidental finding during video-pharyngo-laryngoscopic examinations, and few otolaryngologists have described the clinical implications of this among patient with laryngeal disorders.

Aim
The aim of the study is to document the prevalence of arytenoid adduction asymmetry in patients who had video-pharyngo-laryngoscopy and determine if there is any possible association between arytenoid adduction asymmetry and hoarseness.

Methods
This is a retrospective descriptive study involving patients who had video-pharyngo-laryngoscopic examinations for various indications. The medical charts and video-pharyngo-laryngoscopic examination findings recorded in the stored database in ENT outpatient departments of two institutions over a 2-year period were retrospectively reviewed for age, sex, occupation, presenting complaint, and indication for video-pharyngo-laryngoscopic findings and diagnosis. Arytenoid adduction asymmetry was defined in relation to the position of the corniculate cartilages, cuneiform cartilages, and aryepiglottic angle. All the variables in the data were analyzed using Statistical Product and Service Solution (SPSS) version 25.

Results
A total of 152 out of 209 patients had complete information needed for the review, 59 were males and 93 females with age range 20–91 years, and mean age was 46 ± 15.5 years. The overall prevalence rate for adduction asymmetry was 44.7%. Arytenoid asymmetry was seen commonest among the 5th and 6th decades of life and highest among the professional voice users (55%), while the male-to-female ratio was 1.6:1.
Hoarseness constituted 40.1% of all indications for video-pharyngo-laryngoscopy, with 71% of patients with hoarseness having a primary laryngeal lesion, 26% had laryngopharyngeal reflux, and 3.3% were due to pubertal voice changes. A significant association was found between arytenoid asymmetry of the male gender P-value 0.027 and hoarseness P-value 0.026.

Conclusion
Arytenoid adduction asymmetry is prevalent in the 5th and 6th decades of life, among patients with hoarseness resulting from unilateral primary laryngeal disorders.