bluuebunny/crossref_metadata_2025_split huggingface dataset:
An atlas and evidence-based appraisal framework of psychiatric brain stimulation targets generated by causal network mapping
Authors: Webler Ryan D. , Pines Andrew R. , Chiulli Nicole , Cotovio Goncalo , Darby Ryan R. , Jiang Jing , Joutsa Juho , Li Ningfei , Oliveira-Maia Albino J. , Peng Shaoling , Taylor Joseph J. , Siddiqi Shan H. 
Published: February 2025

AbstractCausal network mapping is an emerging technique that can be used to derive optimal disorder/symptom-specific brain stimulation targets. This technique exploits incidental variability in brain lesion and brain stimulation locations, which creates a natural experiment in which causal inferences can be drawn between lesions or modulation of specific circuits and specific clinical outcomes. Circuits identified by causal network mapping, referred to as symptom-networks, represent candidate disorder/symptom-specific brain stimulation targets. The number of psychiatric symptom-networks has grown rapidly in recent years, creating a need for a comprehensive synthesis. To address this gap, this Resource presents an atlas of 12 psychiatric symptom-network targets and appraises them using an established evaluative framework. We describe how these targets can be localized with and without neuroimaging and highlight key considerations surrounding their trialing and implementation. These materials are designed to spur the translation of symptom-network targets and scaffold advancements in this quickly developing field.
Long-term effect of empagliflozin and dapagliflozin in patients with heart failure undergoing coronary artery surgery/endovascular intervention: Is there a difference between these two SGLT2i on hospitalization, MACE, and mortality?
Authors: özgöl ilhan , Yiğit Gençer Ece , yıldız Cennet , Karabulut Dilay , Turhan Çağlar Fatma Nihan , Işıksungur Bıçakhan Burcu , Yücel Cihan , Yılmaz Melek , Ünal Orçun , Özsoy Sadiye Deniz , Yiğit Zerrin 
Published: February 2025

Title: Long-term effect of empagliflozin and dapagliflozin in patients with heart failure undergoing coronary artery surgery/endovascular intervention: Is there a difference between these two SGLT2i on hospitalization, MACE, and mortality? Objective: This study aims to compare the long-term effects of these two Sodium-Glucose Co-Transporter 2 inhibitors (SGLT2i) on hospitalization, major adverse cardiovascular events (MACE), and mortality in heart failure patients undergoing coronary artery bypass graft surgery (CABG)/percutaneous coronary intervention (PCI) on empagliflozin and dapagliflozin. Methods: 567 patients with heart failure undergoing CABG/PCI between 2014 and 2022 were studied, and 470 patients on empagliflozin and dapagliflozin were analyzed. The two groups of patients with preserved ejection fraction (HFpEF, n= 293) and patients with low/slightly reduced ejection fraction (HFdEF, n= 177) were analyzed in two subgroups: empagliflozin and dapagliflozin users. In addition to hospitalization, MACE and mortality, age, gender, disease history, and laboratory parameters were compared. Patients with (n=123) and without (n=347) cardiac MACE were also compared. Results: No significant difference was found between the groups in terms of age, HbA1c, creatinine levels, and other cardiovascular risk factors. Similar results were obtained in terms of overall mortality, cardiac mortality, MACE, cardiac MACE, and hospitalization. In the HFpEF group comparing dapagliflozin with empagliflozin, overall mortality (17.1% vs. 19.9%, p=0.544), cardiac mortality (10.5% vs. 20%, p=0.341), MACE (29. 6% vs. 26.2%, p=0.522), cardiac MACE (28.3% vs 25.5%, p=0.595) and hospitalization (27% vs 22.7%, p=0.398). Similarly, in the HFrEF group, there was no difference in overall mortality (25.9% vs. 13.8%, p= 0.054), cardiac mortality (15.2% vs. 9.2%, p= 0.246), MACE (31.3% vs 20%, p= 0. 105), cardiac MACE (28.6% vs 18.5%, p= 0.134) and hospitalization (28.6% vs. 18.5%, p= 0.134) were similar between the two SGLT2i. NT-proBNP (1451.38±2769.36 vs. 3052.30±3779.04, p< 0.001) and creatinine (0.98±0.38 vs. 1.12±0.87, p= 0.022) levels were significantly higher in the group with cardiac MACE. Conclusion: Empagliflozin and dapagliflozin did not show a significant difference in their long-term effects on hospitalization, MACE, and mortality in patients with heart failure undergoing coronary artery surgery/endovascular intervention. Larger and multicentre studies are required to confirm these findings. Keywords: Sodium-Glucose Co-Transporter 2 inhibitors, SGLT2i, empagliflozin, dapagliflozin, coronary artery surgery, heart failure, HFpEF, HFrEF, MACE
Identification of modifiable plasma protein markers of cardiometabolic risk in children and adolescents with obesity
Authors: Stinson Sara E. , Huang Yun , Thielemann Roman , Stankevic Evelina , Lund Morten A.V. , Holm Louise A. , Fonvig Cilius E. , Juel Helene Bæk , Borisevich Dmitrii , Thiele Maja , Krag Aleksander , Ängquist Lars , Sørensen Thorkild I.A. , Pedersen Oluf , Christiansen Michael , Holm Jens-Christian , Hansen Torben 
Published: February 2025

AbstractPediatric obesity is associated with multi-organ inflammation and an increased risk of cardiometabolic disease. To identify novel biomarkers of early-onset obesity-related cardiometabolic risk, we performed targeted proteomics, analyzing 149 proteins related to inflammation and cardiovascular disease in a cross-sectional sample of 2,377 children and adolescents with overweight/obesity and 1,647 with normal weight. In addition, we analyzed 64 circulating inflammation-related proteins in 184 children and adolescents, who participated in a 1-year family-based obesity management program. We identified a three plasma protein panel (CDCP1, FGF21 and HAOX1) that improved prediction of hepatic steatosis, compared with the predictive value of liver enzymes alone. In the prospective trial, we found that the non-pharmacological intervention induced a decline in circulating inflammatory cytokine levels, some of which were linked to improvements in cardiometabolic phenotypes. Our results may suggest that circulating proteomic signatures may mediate the associations between pediatric obesity and cardiometabolic risk.
Systematic Review of the Diagnostic Imaging Evaluation of Pulsatile Tinnitus
Authors: Jairam Meghan P. , Kidanemariam Simon , Malik Aleena , Corrales C. Eduardo , Suh Chong Hyun , Guenette Jeffrey P 
Published: February 2025

AbstractObjectiveAggregate published data on the imaging of pulsatile tinnitus as a step toward building a framework for an evidence-based approach to diagnostic imaging for this symptom.Materials & MethodsA systematic review was performed. PUBMED and EMBASE were searched on December 1, 2021 for English-language articles on diagnostic imaging of pulsatile tinnitus. Articles that involved non-standard imaging techniques and those that focused on management of pulsatile tinnitus were excluded. Extracted data included: number of males and females; signs, symptoms, and physical examination findings with associated patient counts; imaging findings; count of patients with imaging-identified cause of pulsatile tinnitus; reported associated interventions and outcomes.Results41 articles were included with a total of 2,633 reported patients. 10 studies were prospective. MRA appears to be capable of identifying many of the same pathologies traditionally diagnosed with DSA. Few head-to-head comparisons were performed. In head-to-head comparisons of MRI and MRA, MRA was often able to identify more pathology. There was no clear relationship identified between specific symptoms and the imaging modality chosen, indicating that the imaging evaluation of pulsatile tinnitus is likely sensitive to the preferences of the evaluating provider.ConclusionThere is limited evidence to inform best practices for the initial imaging evaluation of pulsatile tinnitus and preference-sensitive provider decisions will continue to guide the pulsatile tinnitus workup. We encourage prospective studies with multimodality imaging comparisons to build evidence that would support the development of more effective, efficient, and equitable protocols and pathways for the imaging evaluation of pulsatile tinnitus.Clinical Relevance StatementEvidence is not available in support of any single optimal imaging evaluation of pulsatile tinnitus, but prudent imaging will include evaluation for life-threatening causes such as dural arteriovenous fistula and arteriovenous malformation.Key Points-Many imaging findings associated with pulsatile tinnitus may not be causal.-Current evidence is insufficient to indicate the optimal imaging evaluation.-Local preference-based imaging algorithms are reasonable in the absence of new high-level evidence.
Mosquito Cell Atlas: A single-nucleus transcriptomic atlas of the adultAedes aegyptimosquito
Authors: Goldman Olivia V. , DeFoe Alexandra E. , Qi Yanyan , Jiao Yaoyu , Weng Shih-Che , Houri-Zeevi Leah , Lakhiani Priyanka , Morita Takeshi , Razzauti Jacopo , Rosas-Villegas Adriana , Tsitohay Yael N. , Walker Madison M. , Hopkins Ben R. ,   Mosquito Cell Atlas Consortium, Akbari Omar S. , Duvall Laura B. , White-Cooper Helen , Sorrells Trevor R. , Sharma Roshan , Li Hongjie , Vosshall Leslie B. , Shai Nadav 
Published: February 2025

SummaryThe female mosquito’s remarkable ability to hunt humans and transmit pathogens relies on her unique biology. Here, we present the Mosquito Cell Atlas (MCA), a comprehensive single-nucleus RNA sequencing dataset of more than 367,000 nuclei from 19 dissected tissues of adult female and maleAedes aegypti, providing cellular-level resolution of mosquito biology. We identify novel cell types and expand our understanding of sensory neuron organization of chemoreceptors to all sensory tissues. Our analysis uncovers male-specific cells and sexually dimorphic gene expression in the antenna and brain. In female mosquitoes, we find that glial cells in the brain, rather than neurons, undergo the most extensive transcriptional changes following blood feeding. Our findings provide insights into the cellular basis of mosquito behavior and sexual dimorphism. The MCA aims to serve as a resource for the vector biology community, enabling systematic investigation of cell-type specific expression across all mosquito tissues.
ArabidopsisTITAN LIKEis required for U12-type intron splicing, especially for AT–AC subtypes
Authors: Niwa Tomoko , Miyamoto Junshin , Iwai Haruka , Kojima Takaaki , Suzuki Takamasa 
Published: February 2025

AbstractMany eukaryotes have two types of spliceosome, i.e., the U2-dependent and U12-dependent spliceosomes. The terminal dinucleotides of almost all introns spliced by the U2-dependent spliceosome are GT–AG, whereas the most of the rest involved the U12-dependent spliceosome ending in AT–AC. How the U12-dependent spliceosome splices two types of introns with different ends also remains poorly understood. For example, it has been reported that human CENATAC is a subunit of U12-dependent spliceosome and is—uniquely—required for the splicing of AT–AC introns. The Arabidopsis genome contains one gene calledTITAN LIKE(TTL), a homolog ofCENATAC, but the function this plays in splicing is unknown. In this paper we created a weak TTL mutant namedttl-142, and investigated the function of TTL during splicing. We found thatttl-142had a 14-residue deletion, and that homozygous mutants showed morphological abnormalities. Most U12-dependent introns were less spliced inttl-142than in the wild type, and the splicing of AT–AC introns was particularly suppressed. Splicing suppression inttl-142was more extensive than in a DROL1 mutant, which contains a mutation in a gene that is specifically required for AT–AC intron splicing. In contrast, fewer genes showed changes in expression levels inttl-142than indrol1, and most DEGs inttl-142anddrol1were different. These results suggest that the phenotypes ofttl-142anddrol1mutants may correspond to the impairment of specific spliceosomal functions.
Gut Microbiome Signatures Reflect Within-Host Subtype Diversity ofBlastocystisin Non-Human Primates
Authors: Ma Pingping , Mu Wenjie , Wang Yugui , Liu Yihui , Zou Yang , Pan Hong , Zhang Long , Chen Lixian , Yang Yongpeng , Luo Weifei , Wang Shuai 
Published: February 2025

AbstractBlastocystisis a prevalent gut eukaryote intricately associated with the gut microbiota. This genetically diverse protozoan exhibits significant intra-host subtype heterogeneity, yet the implications of this diversity for the host gut microbiome remain poorly understood. Here, we investigated the interactions betweenBlastocystisand gut microbiota in non-human primates at the level of subtypes, using a comprehensive investigation of gut microbiota forBlastocystiscarriers of captiveMacaca fascicularis(discovery cohort, n = 100) andMacaca mulatta(validation cohort, n = 26). We identified highly prevalent intra-host co-occurrence patterns ofBlastocystis SSUrRNA-based subtypes, primarily dominated by Subtype 1(ST1) or ST3. These patterns were associated with compositional and structural variations in the gut microbiome but were not significantly influenced by host covariates such as sex, age, or BMI. Specifically, Ruminococcaceae-enterotype was enriched in the patterns dominated by ST1, whereasLimosilactobacillus-enterotype was predominantly identified in the patterns dominated by ST3. We discovered that the absolute abundance ofBlastocystiswas a critical determinant in elucidating this association across concurrent patterns.In vivoexperiments in a new cohort (n = 11) demonstrated that lactic acid bacteria, enriched in theLimosilactobacillus-enterotype, were sufficient to reduceBlastocystisload. We validated the strong association between gut microbiome composition andBlastocystisload inM. mulatta, confirming that specific microbial features could quantitatively predictBlastocystisstatus in both species. Our findings establish a direct link between gut microbial variations, intra-host genetic heterogeneity, and absolute abundance inBlastocystisfor non-human primates.
Extracellular vesicles aid in the transfer of long-term associative memory betweenCaenorhabditis elegans
Authors: Bhar Monmita , Nandi Tanumoy , Narayanan Hari , Kishore Kamal , Babu Kavita 
Published: February 2025

AbstractMemory formation is necessary for the survival of animals across phyla. Here, we elucidate the mechanism underlying the formation of long-term associative memory (LTAM) formed by treatingCaenorhabditis eleganswith a volatile chemoattractant and heat. Previous work has shown that training animals with a paradigm involving heat and isoamyl alcohol (IAA) simultaneously, causesC. elegansto lose their attraction to IAA. In this study, we elaborate on the mechanism behind this LTAM formation and suggest that during training with heat and IAA,C. elegansrelease extracellular vesicles (EVs) that upon being taken up by the same trained animals or their untrained counterparts causes the organism to lose attraction to IAA. Our data suggests that the vesicles are highly specific to the training paradigms used and differ with differing cues. Finally, we show that this mechanism of transfer of LTAM appears to be conserved betweenC. elegansandC. briggsaeallowing for both intra and interspecies transfer of memory.
Organizational ambidexterity and innovation management in traditional communities: an investigation in Associação Kalunga Comunitária do Engenho II
Authors: Veneziani Sheyla , Soares Juliano 
Published: February 2025

PurposeThe purpose of this study is to understand how the managers of the Associação Kalunga Comunitária do Engenho II (AKCE) used the assumptions of organizational ambidexterity during the pandemic period in their communities to mitigate the impacts of coronavirus disease 2019 (COVID-19), as well as to report the main innovative practices adopted by the AKCE.Design/methodology/approach The study is classified as exploratory, with a qualitative approach, and the research procedure chosen was semi-structured interviews. The data obtained came from the transcription of the interviews and field observation, using the content analysis method.Findings The community used constructs of contextual ambidexterity during the COVID-19 pandemic. Video conferences, online management and mechanized farming are characteristics of alignment, and the creation of websites, online sales, medicinal plant project and community farming refer to adaptability.Practical implications This study demonstrates how innovation was fostered in the Kalunga community, highlighting how the pandemic moment was overcome.Social implications The study makes it possible to broaden society’s knowledge about centennial communities; besides divulging more about quilombola communities, in a scenario of historical reparation in which the communities were mapped for the first time by the 2022 Census.Originality/value It is possible to find characteristics related to ambidexterity in organizations that do not aim for profit.
Optimizing circular economy practices in construction: a systematic review of material management strategies
Authors: Ibe Chukwumaobi Ndukwe , Serbescu Andreea , Hossain Mohataz , Ibe Ikechukwu Ikwegbu 
Published: February 2025

PurposeAlthough circular economy (CE) principles are gaining increasing attention, a systematic understanding of material management strategies for an effective CE transition in construction is still lacking. This review addresses this gap by examining global construction practices, focusing on waste reduction and recycled materials. The study identifies key material management strategies for optimizing CE practices, supporting an integrated sustainable approach in construction.Design/methodology/approachA bibliometric analysis of 17,600 papers published from 2015 to 2022 was conducted, leading to an in-depth investigation of 44 relevant articles. The systematic review revealed material management strategies such as on-site sorting, deconstruction planning, modular building and reverse logistics, which were evaluated using quantitative and qualitative comparative analysis.FindingsChina emerges as a leader in construction material management research, reflecting significant global interest. Key findings indicate that strategies like design for deconstruction (DfD), minimization at design and modular construction achieve higher waste reduction, while building information modelling and on-site sorting show lower cost-saving potential. This research uniquely validates the structural feasibility of the most common recycled materials through qualitative comparative analysis of studies examined, emphasizing the critical role of CE design principles in sustainable construction.Practical implicationsThe study validates circular design concepts like DfD, minimization of resource use at design and modularization, which facilitate closed-loop planning. Circular construction systems are technically and economically feasible, underscoring the need for mass implementation. Recommendations on material management and transition strategies are provided for stakeholders based on CE principles.Originality/valueThis study synthesizes recent research on sustainable material management, uniquely validating recycled materials’ structural viability and comparing material management strategies for optimal waste reduction and cost savings. It emphasizes multi-stakeholder initiatives spanning policy, industry and academia, providing practical insights to embed CE practices in sustainable construction.
South Asian Diaspora in Italy: settlement patterns and locational factors
Authors: Morettini Gabriele , Valentini Enzo 
Published: February 2025

PurposeThis paper empirically explores the spatial distribution of the four major South Asian communities in Italian municipalities between 2004 and 2014 and identifies the key determinants of these patterns.Design/methodology/approach SAP’s (South Asian People) location patterns are investigated through a large and varied set of explanatory variables. Employing a settlement model and the inflow approach, we disentangle the impact of conventional pull factors and the network effect.FindingsWe observe how SAP in Italy are concentrated in some specific locations, away from the natives. This decentralised clustered distribution results from a mix of contextual pull factors and ethnic networks with a strong local character. However, national communities exhibit striking differences in location patterns, determined by different pull factors. We found evidence of the overall persistence of drivers over time, which generated substantial inertia in the settlement patterns of SAP national groups over the 2008 crisis.Practical implicationsWe stressed how SAP have different settlement patterns and drivers, so they cannot be treated as a unicum. They call for place-based policies tailored to the specific needs of individual communities.Originality/valueWe examine the relevant but under-researched SAP diaspora in Italy by comparing the Indian, Pakistani, Bangladeshi and Sri Lankan location models across all the Italian municipalities and checking if and how their spatial distribution changed over the 2008 crisis.
Growth effects of FDI inflows, financial development and institutional quality in emerging economies: a panel quantile regression approach
Authors: Mensah Barbara Deladem , Tweneboah George , Asongu Simplice , Tagbotor Thomas Elorm 
Published: February 2025

Purpose
This study aims to examine the growth effects of foreign direct investment (FDI) inflows, financial development and institutional quality in emerging economies. The research covers 24 years of panel data of 33 selected emerging economies for the period spanning from 1996 to 2020.

Design/methodology/approach
The Pedroni and Westerlund panel cointegration tests were performed to ascertain a long run relationship among the studied variables while the panel quantile regression approach was applied to account for the heterogeneous effect of the exogenous variables on economic growth.

Findings
The study revealed among other things that FDI inflows, financial development and institutional quality all have positive effects on economic growth in the selected emerging economies. It further revealed that the growth effects of these explanatory variables are evidently heterogeneous.

Research limitations/implications
The implications of this study include the need to increase FDI inflows, especially environmentally friendly FDIs, establish a well-developed financial sector and improve institutional quality so as to accelerate growth in the selected emerging economies.

Originality/value
This paper contributes to extant literature by answering the question of whether the growth effects of FDI inflows, financial development and institutional quality can differ in sign and or magnitude depending on the performance of a country’s growth. The findings of this study may help governments and policymakers to develop very good growth-promoting policies in accordance with the behavior of productivity growth.