bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Integrated Approach to General Practice Mental Health Training: The Importance of Context
Authors: Hodgins Gene , Judd Fiona , Davis Julian , Fahey Anne 
Published: March 2007

Objective: The high prevalence of mental disorders and the barriers to detection and treatment of these in general practice are well recognized. As such, the government has placed great emphasis on training general practitioners (GPs) in primary care mental health and on the provision of support for GPs in the delivery of such services. The current paper aims to evaluate a local, rural training program in mental health for GPs. We hypothesized that local ‘context-driven’ training would lead to increased knowledge and reported change in practice by GPs with mental health patients. Method: Locally developed and delivered ‘Level 1’ training was offered to GPs through the Better Outcomes in Mental Health Care initiative. The training was provided with 6-hour workshops covering mental health assessment and management planning. The training was evaluated through pre- and 6-week post-questionnaires assessing attitudes and practice with respect to treatment of patients with mental health problems. Results: Forty-nine GPs from the Loddon Campaspe Southern Mallee region of Victoria participated in the training. Following the 6-hour workshop, there was an increase in reported use of psychoeducation for patients with depression, use of cognitive behavioural therapy for patients with anxiety, and ease in obtaining advice to assist with the management of psychosis. Conclusions: GP mental health education should take into consideration the local context, cover systems issues as well as skills development, and aim to develop personal relationships between mental health clinicians and GPs to enhance outcomes.
Causal sentence production in children with language impairments
Authors: Donaldson Morag L. , Reid Jennifer , Murray Claire 
Published: March 2007

AbstractBackground: The production of causal sentences (e.g. The house went on fire because the girl was playing with matches) is a key component of the ability to produce explanations, which in turn is an important aspect of children's developing discourse skills. While informal observations by professionals suggest that children with language impairments often have difficulties in producing (and comprehending) causal sentences, there is a dearth of systematic research evidence on the scope and characteristics of such difficulties.Aims: The study reported herein aimed to establish the scope and characteristics of the difficulties that children with language impairments have with causal sentence production. In particular, it investigated whether they have difficulties with (1) producing causal connectives (because and so), (2) producing semantically appropriate causal sentences, and (3) coordinating the production of more than one clause.Methods & Procedures: The performance of 5–7‐year‐old children with language impairments (the LI group, n = 30) was compared with that of typically developing chronological age peers (the CA group, n = 30) on four elicited production tasks designed to encourage children to talk about pictures of causally related events. The tasks required the children to answer causal questions, to complete and imitate causal sentences, and to produce full causal sentences.Outcomes & Results: Although the groups did not differ in the overall frequency with which they used causal connectives, the LI group produced fewer causal connectives than the CA group on tasks involving higher processing demands, as well as producing a lower percentage of semantically appropriate responses on most tasks. The LI group found imitating causal sentences more difficult than answering causal questions and completing causal sentences, whereas the CA group showed a similar level of performance across these three tasks.Conclusions: Although 5–7‐year‐old children with language impairments have causal expressions in their repertoire, they have marked and extensive problems in using these expressions appropriately and in producing full causal sentences even when these are modelled for them. Given the educational importance of explanation, there is a clear need for interventions to target both the semantic appropriateness of causal sentence production and the frequency of use of causal connectives, especially in contexts where children have to cope with the additional processing demands associated with producing two‐clause sentences and/or with producing causal sentences autonomously.
Trainees’ experiences of impasses in counselling and the impact of group supervision on their resolution: A pilot study
Authors: De Stefano Jack , D'Iuso Nadia , Blake Emily , Fitzpatrick Marilyn , Drapeau Martin , Chamodraka Martha 
Published: March 2007

AbstractA qualitative analysis of eight interviews was conducted to answer the following questions: ‘How do trainees experience a clinical impasse?’ and ‘How does the experience of group supervision help or hinder the resolution of these impasses?’ MA students in a counselling psychology program at a Canadian university were interviewed at two points in time: after experiencing a clinical impasse and after receiving group supervision for the impasse. Data were analyzed using consensual qualitative research methodology (CQR; Hill, Thompson & Nutt‐Williams, 1997) to identify themes relative to our two questions. Results indicated that when trainees experienced an impasse they reacted with negative emotions because they did not know what to do in session with the client at that point in time, and they experienced the impasse as a failure. Trainees reported seeking supervision to obtain validation/support, and found that supervision provided them with this. As well, a new perspective on the impasse event and increase in self‐awareness was reported. An unexpected finding included dissatisfaction with the dynamics of the supervision group. These findings have implications for trainers: for understanding the supervisory needs of trainees, for appreciating the impact of supervision on counsellor development, and for generating alternate practices of supervision.
Gender‐related events in psychotherapy supervision: Female trainee perspectives
Authors: Walker Jessica A. , Ladany Nicholas , Pate-Carolan Lia M. 
Published: March 2007

AbstractA gender‐related event is an interaction, process, or event in psychotherapy supervision that the trainee felt was directly or indirectly related to, or influenced by: (a) the trainee's sex or the client's sex, (b) the social construction of gender, or (c) stereotypes and assumptions of gender roles. Gender‐related events were studied for 111 female trainees. Approximately half (48%) of the reported events were considered supportive. The two most frequently reported supportive gender‐related events were when supervisors discussed an academic conceptualization of a client integrating gender, or processed gender‐related transference and countertransference issues with their trainees. The most common non‐supportive gender‐related events included those where supervisors made comments based on stereotypes of the trainee or when supervisors dismissed a gender‐related conversation initiated by the trainee. Content and frequency of supportive and non‐supportive gender‐related events were significantly related to the supervisory alliance as well as the frequency of trainee self‐disclosure.
The impact of clinical supervision on counsellors and therapists, their practice and their clients. A systematic review of the literature
Authors: Wheeler Sue , Richards Kaye 
Published: March 2007

AbstractIn 2005 the British Association for Counselling and Psychotherapy (BACP) commissioned a systematic review of the research evidence related to the impact of supervision on counsellors and psychotherapists, their practice and their clients. This paper reports on some of the findings of this review, specifically from articles published in this area since 1980. Detailed inclusion and exclusion criteria were agreed. EPPI‐Reviewer software was used to organise and analyse the articles that met the inclusion criteria. This article reviews 18 individual published studies. The quality of evidence is variable, but supervision is consistently demonstrated to have some positive impacts on the supervisee.
A Coordination Model for Improving Software System Attack-Tolerance and Survivability in Open Hostile Environments
Authors: Ren Shangping , Yu Yue , Kwiat Kevin A. , Tsai Jeffrey 
Published: March 2007

This paper presents a coordination model that contains three active entities: actors, roles, and coordinators. Actors abstract the system's functionalities while roles and coordinators statically encapsulate coordination constraints and dynamically propagate these constraints among themselves and onto the actors. A software system's attack-tolerance and survivability in open hostile environments are enhanced through appropriate constraint propagations and constraint enforcements. The role represents a group of actors that share the same set of behaviors declared by the role. Coordination and coordination constraints in the model are categorized into two classes: inter-role coordination and intra-role coordination. The coordinators are responsible for inter-role coordination; while the roles are not only abstractions for a set of behaviors they also coordinate the actors which share the same role. This setting implies that both the coordination constraints and coordination activities are decentralized and distributed among the coordinators and the roles. The decentralization not only shields the system from single point of failures, but also provides a foundation that survivable feedback loops can be built upon. The survivable feedback loops presented in the model resist the contamination of the system by faulty elements and thereby protect the whole system from being broken down by single failures.
Extraorbital Skull Base Idiopathic Pseudotumor
Authors: Mangiardi Jason R. , Har‐El Gady 
Published: March 2007

AbstractObjectives/Hypothesis: The term idiopathic pseudotumor (IP) refers to a nonspecific, nonneoplastic inflammatory process without identifiable local or systemic causes, which is one of the most common causes of intraorbital space‐occupying lesions. Occasionally, orbital pseudotumors may extend to other areas of the skull base. Rarely, pseudotumors may present as a skull base mass with no involvement of the orbit. The ophthalmology literature has detailed reviews of IP as an intraorbital space‐occupying lesion, but lesions involving only the skull base and sparing the orbit are rare in the literature. We present a review of our experience with six patients with extraorbital skull base pseudotumor and a review of the relevant literature.Method: Retrospective case study.Results: We treated six patients with extraorbital skull base pseudotumor between 1996 and 2004. Four patients had lesions in the pterygopalatine and/or infratemporal fossae, and two patients had lesions in the superior aspect of the parapharyngeal space. Five patients had excellent initial response to steroids. Two of the pseudotumors recurred. One patient partially responded to steroids and is currently stable with limited disease. Our literature review demonstrated 16 previously published reports of IP of the skull base sparing the orbit.Conclusions: A well‐documented intraorbital lesion, inflammatory pseudotumor may present outside the orbit. Treatment of IP of the skull base is controversial and may involve corticosteroids or surgical resection, or both. Other chemotherapeutic agents and radiotherapy may be considered in steroid‐resistant patients. Pathological subtype, ease and safety of resection, safety of high‐dose corticosteroid use, the surgeon's comfort, and the patient's preference must be included in the decision‐making process for treatment.
Protein Interactions Captured by Chemical Cross-linking: One-Step Cross-linking with Formaldehyde: Figure 1.
Authors: Nadeau Owen W. , Carlson Gerald M. 
Published: April 2007

INTRODUCTIONThis protocol describes a method for chemical cross-linking of proteins using formaldehyde. With the exception of zero-length cross-linkers, formaldehyde has the shortest cross-linking span (~2-3 Å) of any cross-linking reagent, thus making it an ideal tool for detecting specific protein-protein interactions with great confidence. Despite its simple chemical structure (CH2O), formaldehyde’s single carbonyl group functions essentially as a homobifunctional reagent and is capable of conjugating targets through two different chemical pathways. In Mannich-type reactions, which typically require elevated temperatures (37°C or above) for a period of 2-24 hours for acceptable yields, formaldehyde condenses with amines (1°, 2°, or salts of ammonia) and compounds with active hydrogens to form stable cross-links. Formaldehyde also reacts with amines to form highly reactive immonium cations that are reactive toward protein-containing nucleophiles, including sulfhydryls, amines, phenols, and imidazoles. The latter reaction is more rapid than the former and is generally the more predominant in typical protein cross-linking reactions at ambient temperatures.
Protein Interactions Captured by Chemical Cross-linking: Two-Step Cross-linking with ANB•NOS: Figure 1.
Authors: Nadeau Owen W. , Carlson Gerald M. 
Published: April 2007

INTRODUCTIONThe two-step method of cross-linking with the photoreactive cross-linker ANB•NOS (7.7 Å) provides an additional layer of control over the one-step method with traditional bifunctional reagents. In this method, the initial modification and purification of one or more of the protein reactants can be carried out prior to cross-linking, thus minimizing both monoderivatization and nonspecific cross-linking. This method is also useful for detecting conformational changes in stable protein complexes. The complex can be labeled under solution conditions that favor, for example, an inactive conformer; it can then be purified and exchanged into a solution that favors an active conformation. In this case, any differences in cross-linking observed under the two conditions will reflect structural changes that occur at each site of modification on the complex, rather than conformation-dependent cross-linking at different sites (which is a more likely scenario when a complex is modified with the same cross-linking reagent under different reaction conditions).
Using Genetically Engineered Kinases to Screen for Novel Protein Kinase Substrates: Identification of a Mutant Kinase/ATP Analog Pair
Authors: Eblen Scott T. , Kumar N. Vinay , Weber Michael J. 
Published: April 2007

INTRODUCTIONThis protocol describes a method for studying protein kinases and their substrates by generation of mutant kinase enzymes that can incorporate ATP analogs into the substrate. This method was used to identify substrates of extracellular signal-regulated kinase 2 (ERK2). Once mutations (called “pocket mutations”) have been generated in the kinase, the next step is to screen ATP analogs for their compatibility with the kinase mutant. This screening is best performed in a two-step process. The first step involves assaying the ability of an ATP analog to inhibit the incorporation of radioactive phosphate from normal [γ-32P]ATP into a known substrate in an in vitro kinase reaction. Because certain analogs might be able to interact with the ATP-binding site of the kinase but be unable to be used by the kinase as an ATP source, it is also necessary to directly test the ability of the mutant kinase to phosphorylate a substrate with analog ATP. Doing this requires either radiolabeled ATP analogs or, preferably, a phospho-specific antibody to the phosphorylation site on the known substrate. (A phospho-specific antibody allows a large number of ATP analogs to be screened without the need for radioactivity.) The kinase/ATP analog pair that provides the best phosphorylation of the substrate is then used for future experiments. Only those analogs that cannot be used by the wild-type kinase and other cellular kinases are chosen.
Zinc/Imidazole Procedure for Visualization of Proteins in Gels by Negative Staining
Authors: Simpson Richard J. 
Published: April 2007

INTRODUCTIONThe zinc/imidazole staining procedure for visualizing proteins in acrylamide gels is based on differential salt binding. Because protein-bound salts (e.g., dodecyl sulfate or the heavy cation zinc) are chemically less active than free zinc ions in the gel, precipitation of an insoluble salt is much slower in those regions of the gel occupied by proteins than in the gel background where zinc dodecyl sulfate precipitates. The result is a “negative stain,” with translucent proteins and an opaque gel background, due to zinc dodecyl sulfate precipitation. The sensitivity of the method has been markedly improved by altering the composition of the precipitated salt to a complex of zinc and imidazole. This protocol provides two methods: reverse stain using imidazole, SDS, and zinc, and double-staining using Coomassie blue stain followed by zinc/imidazole.
Preparation of GST Fusion Proteins
Authors: Einarson Margret B. , Pugacheva Elena N. , Orlinick Jason R. 
Published: April 2007

INTRODUCTIONThis protocol describes the preparation of glutathione-S-transferase (GST) fusion proteins, which have had a wide range of applications since their introduction as tools for synthesis of recombinant proteins in bacteria. GST was originally selected as a fusion moiety because of several desirable properties. First and foremost, when expressed in bacteria alone, or as a fusion, GST is not sequestered in inclusion bodies (in contrast to previous fusion protein systems). Second, GST can be affinity-purified without denaturation because it binds to immobilized glutathione, which provides the basis for simple purification. Consequently, GST fusion proteins are routinely used for antibody generation and purification, protein-protein interaction studies, and biochemical analysis.
Post‐structuralism, hypertext, and the World Wide Web
Authors: Tredinnick Luke 
Published: March 2007

PurposeThe purpose of this paper is to explore the application of post‐structuralist theory to understanding hypertext and the World Wide Web, and the challenge posed by digital information technology to the practices of the information profession.Design/methodology/approachThe method adopted is that of a critical study.FindingsThe paper argues for the importance of post‐structuralism for an understanding of the implications of digital information for the information management profession.Originality/valueFocuses on an epistemological gap between the traditional practices of the information profession, and the structure of the World Wide Web.
Design and CFD analysis of centrifugal compressor for a microgasturbine
Authors: Aghaei tog Reza , Mesgharpoor Tousi A. , Soltani M. 
Published: March 2007

PurposeThis paper aims to show how a good compressor can be designed and modeled with CFD steady models and to explain reasons for discrepancies between experiment (1D design) and 3D CFD analysis.Design/methodology/approachA model with only one impeller channel was used to compare 1D design data, which were obtained from centrifugal compressor design code, written and developed by the authors. The often used model for CFD analysis of turbo machinery, known as “frozen‐rotor” model, only yields satisfying results for efficiency and pressure ratio, at and near the point of best efficiency. For this case, the static pressure shows a nearly uniform circumferential distribution at the inlet of the diffuser, which numerically leads to more homogeneous flow rates through the single vane channels, and thus to a more realistic time averaged flow distribution.FindingsThe numerical results with respect to performance data showed quite good agreement with experimental data at and near the operating point of best efficiency.Originality/valueThis paper offers a combined 1D and 3D numerical approach in turbo machinery design, especially in radial compressible turbo machines design.
Corporate strategy and shareholder value during decline and turnaround
Authors: Furrer Olivier , Rajendran Pandian J. , Thomas Howard 
Published: April 2007

PurposeThe paper aims to assess the impact of corporate strategy on shareholder value in decline and turnaround situations.Design/methodology/approachA sample of 45 turnaround firms was selected and matched against a control sample which did not face continuous decline over the time period studied. The impact of corporate strategy on shareholder value was tested using cumulative beta excess return measures to capture the long‐term basis of corporate strategy.FindingsThe paper finds that the beta excess return measures captured the hypothesized relationships between strategy and shareholder value for the sample firms studied.Practical implicationsBeta excess return measures are superior to case studies or event studies for identifying the long‐term effects of corporate strategy.Originality/valueRelatively few studies have compared the strategies of turnaround firms with a matched sample of non‐declining firms. The use of cumulative beta excess returns to assess long‐term valuation of corporate strategy is original.
Driving a resource orientation: reviewing the role of resource and capability characteristics
Authors: Chmielewski Danielle A. , Paladino Angela 
Published: April 2007

PurposeThis study seeks to introduce the role of resource and capability characteristics as drivers of a resource orientation (RO) and to examine empirically these relationships in different market conditions.Design/methodology/approachThis study was conducted using a nation‐wide survey distributed to key informants of multiple business units. Multiple regression was used to assess the relationships. RO is used as a proxy for the implementation of the resource‐based view (RBV). The RO is also tested against performance outcomes to examine the robustness of the model that has been examined.FindingsFindings showed significant relationships between resource and capability characteristics and RO. These relationships were shown to be robust across various market conditions. RO also depicted significant, positive relationships with all four performance indicators that were assessed. Industry conditions were found to strengthen some of these relationships.Research limitations/implicationsThe results are limited to cross‐sectional data that prevent the determination of causality. In addition, it is a nation‐specific study that may not be generalisable to alternative settings. This presents an opportunity for further research to replicate this study in other nations and/or industries. The research presents implications for further theory development and suggests that management can focus on developing unique resource bundles to improve company performance; however, they will need to be attentive to the competitive environment in which they compete.Originality/valueThis is the first study that empirically evaluates drivers of an RO and further tests the scale that was applied by Paladino. Additionally, this study illustrates that the RBV can be empirically tested through the use of an RO to have a demonstrable impact on financial and non‐financial elements of performance.