bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ruthenium(II)‐katalysierter Late‐Stage Einbau von N‐Aryltriazolen und ‐tetrazolen mit Sulfoniumsalzen per C−H‐Aktivierung
Authors: Simon Hendrik , Zangarelli Agnese , Bauch Tristan , Ackermann Lutz 
Published: April 2024

AbstractDie Late‐Stage‐Funktionalisierung von pharmazeutischen Wirkstoffen ist eine zentrale Herausforderung in der medizinischen Chemie. Darüber hinaus sind N‐Aryltriazole und Tetrazole wichtige strukturelle Motive, die das Potenzial haben, die Aktivität verschiedener Arzneimittelmoleküle zu steigern. Unter Verwendung leicht zugänglicher Dibenzothiopheniumsalze für die Ruthenium‐katalysierte C−H‐Arylierung wurden diese Gerüste in einer Vielzahl bioaktiver Verbindungen eingeführt. Unsere Methodik verwendet kostengünstiges Ruthenium, KOAc als milde Base und ermöglicht den Zugang zu einer Vielzahl von hochdekorierten Triazol‐ und Tetrazol‐haltigen Arzneimittelderivaten.
Polyurethane‐based cross‐linked nano spheres and their application in toughening epoxy resin
Authors: Shi Wei , Li Jian , Song Ming , Han Yi , Wang Chenyi , Ren Qiang 
Published: April 2024

AbstractToughening thermo‐setting resins with both high impact strength and tensile strength is a challenging issue. In this study, a novel cross‐linked polyurethane nano spheres for toughening epoxy resin were prepared by self‐emulsification method with hexamethylene diisocyanate trimer (HDI trimer) and diethylene triamine (DETA) as the crosslinkers. The structure, morphology and particle size of cross‐linked polyurethane nano spheres were investigated by infrared spectroscopy, laser particle size analyzer and scanning electron microscopy. Results showed that the prepared cross‐linked polyurethane nano spheres showed spherical shape and had the size in the range from 40 to 258 nm. The application of cross‐linked polyurethane nano spheres in toughing epoxy resin was investigated. The results showed that cross‐linked polyurethane nano spheres can be uniformly dispersed in epoxy resin and no obvious aggregation phenomenon was observed. And the tensile strength and impact strength of epoxy resin can be increased simultaneously when the cross‐linked polyurethane nano spheres were used in toughening epoxy resin. With the increase of the amount of polyurethane nano spheres in epoxy resin, both the tensile strength and impact strength of epoxy resin had the trend of first increase and then decrease. The amount of HDI trimer in the microspheres had a great impact on their toughening effect on epoxy resin. When the cross‐linked polyurethane nano spheres contained HDI trimer content of 12 wt% and the amount of the nano spheres in epoxy resin was 8 wt%, the impact strength of the epoxy resin can reach as high as 23 kJ/m2, which was 4.33 times that of pristine epoxy resin. And the tensile strength of toughened epoxy resin was 50.7 MPa, which was at same level of that of pristine epoxy resin. The results of this study indicate that the cross‐linked polyurethane nano spheres have a great potential in toughening thermo setting resins, such as epoxy resin.
Porphysome Engineered With Specific Protein Binding Sites as a Multimodal Theranostic Nanocarrier for Targeted Protein Delivery
Authors: Ayyari Niloofar , Vaezi Zahra , Ashin Zeinab Fotouhi , Karimi Elham , Mohsenzadeh haji Fatemeh , Nikkhah Maryam , Naderi‐Manesh Hossein 
Published: April 2024

AbstractThe immobilization of proteins on the surface of carriers is challenging due to the loss of protein structure and function in this process. Here, we report the development of the protein immobilization on the surface of the metallated‐porphyrin complex in the porphysome nanocarrier. The conjugated Ni‐porphyrin to fatty acid (as a tail) has been synthesized and independently placed at the depth of the bilayer center of Dipalmitoylphosphatidylcholine (DPPC) in which the Ni‐porphyrin was at the polar region of the membrane and is thus superficial. This porphysome (DPPC: Ni‐porphyrin, 4 : 1 mole ratio) was formed by supramolecular self‐assembly with a diameter of 173±7 nm and zeta potential −8.5±3.4 mv, which exhibited no significant toxicity at the experimental concentrations and acceptable cellular uptake on MCF‐7 cells. The physicochemical properties and specific protein binding sites of the firefly luciferase as a model protein into the porphysome (1 : 2 mole ratio) show the conjugation efficiency about 80 % and the conformation of protein was completely maintained. Furthermore, bioluminescence assay and SDS‐PAGE confirmed the preservation of protein function. The stabilized platform of porphyrin‐lipid structure can potentially improve the efficacy of protein functionality for a particular display, shifting porphysomes from a simple carrier to a therapeutic agent.
Systematic Evaluation of Benchmark G4 Probes and G4 Clinical Drugs using three Biophysical Methods: A Guideline to Evaluate Rapidly G4‐Binding Affinity
Authors: Laigre E. , Bonnet H. , Beauvineau C. , Lavergne T. , Verga D. , Defrancq E. , Dejeu J. , Teulade‐Fichou M.‐P. 
Published: April 2024

AbstractG‐quadruplex DNA structures (G4) are proven to interfere with most genetic and epigenetic processes. Small molecules binding these structures (G4 ligands) are invaluable tools to probe G4‐biology and address G4‐druggability in various diseases (cancer, viral infections). However, the large number of reported G4 ligands (>1000) could lead to confusion while selecting one for a given application. Herein we conducted a systematic affinity ranking of 11 popular G4 ligands vs 5 classical G4 sequences using FRET‐melting, G4‐FID assays and SPR. Interestingly SPR data globally align with the rankings obtained from the two semi‐quantitative assays despite discrepancies due to limits and characteristics of each assay. In the whole, PhenDC3 emerges as the most potent binder irrespective of the G4 sequence. Immediately below PDS, PDC‐360A, BRACO19, TMPyP4 and RHPS4 feature strong to medium binding again with poor G4 topology discrimination. More strikingly, the G4 drugs Quarfloxin, CX5461 and c‐PDS exhibit weak affinity with all G4s studied. Finally, NMM and Cu‐ttpy showed heterogeneous behaviors due, in part, to their physicochemical particularities poorly compatible with screening conditions. The remarkable properties of PhenDC3 led us to propose its use for benchmarking FRET‐melting and G4‐FID assays for rapid G4‐affinity evaluation of newly developed ligands.
Decoupling of nitrogen allocation and energy partitioning in rice after flowering
Authors: Zhong Duwei , Chi Yonggang , Ding Jianxi , Zhao Ning , Zeng Linhui , Liu Pai , Huang Zhi , Zhou Lei 
Published: April 2024

AbstractEstimation of energy partitioning at leaf scale, such as fluorescence yield (ΦF) and photochemical yield (ΦP), is crucial to tracking vegetation gross primary productivity (GPP) at global scale. Nitrogen is an important participant in the process of light capture, electron transfer, and carboxylation in vegetation photosynthesis. However, the quantitative relationship between leaf nitrogen allocation and leaf energy partitioning remains unexplored. Here, a field experiment was established to explore growth stage variations in energy partitioning and nitrogen allocation at leaf scale using active fluorescence detection and photosynthetic gas exchange method in rice in the subtropical region of China. We observed a strongly positive correlation between the investment proportion of leaf nitrogen in photosynthetic system and ΦF during the vegetative growth stage. There were significant differences in leaf energy partitioning, leaf nitrogen allocation, and the relationship between ΦF and ΦP before and after flowering. Furthermore, flowering weakened the correlation between the investment proportion of leaf nitrogen in photosynthetic system and ΦF. These findings highlight the crucial role of phenological factors in exploring seasonal photosynthetic dynamics and carbon fixation of ecosystems.
Restoring democratic stability: A backcasting wheel approach
Authors: Szostak Rick 
Published: April 2024

AbstractThis paper performs a backcasting wheel analysis of the issue of democratic backsliding. It identifies an interacting set of proximate causes of democratic backsliding, and then a set of complementary strategies for addressing the root causes of each of these. It takes an interdisciplinary systems‐based approach throughout. The paper is grounded in an extensive survey of several literatures in multiple disciplines. It shows how the backcasting wheel complements other methods employed in anticipation and future studies more generally.
Fast detection of moisture content and freshness for loquats using optical fiber spectroscopy
Authors: Meng Qinglong , Feng Shunan , Tan Tao , Wen Qingchun , Shang Jing 
Published: April 2024

AbstractDetection of the moisture content (MC) and freshness for loquats is crucial for achieving optimal taste and economic efficiency. Traditional methods for evaluating the MC and freshness of loquats have disadvantages such as destructive sampling and time‐consuming. To investigate the feasibility of rapid and non‐destructive detection of the MC and freshness for loquats, optical fiber spectroscopy in the range of 200–1000 nm was used in this study. The full spectra were pre‐processed using standard normal variate method, and then, the effective wavelengths were selected using competitive adaptive weighting sampling (CARS) and random frog algorithms. Based on the selected effective wavelengths, prediction models for MC were developed using partial least squares regression (PLSR), multiple linear regression, extreme learning machine, and back‐propagation neural network. Furthermore, freshness level discrimination models were established using simplified k nearest neighbor, support vector machine (SVM), and partial least squares discriminant analysis. Regarding the prediction models, the CARS‐PLSR model performed relatively better than the other models for predicting the MC, with R2P and RPD values of 0.84 and 2.51, respectively. Additionally, the CARS‐SVM model obtained superior discrimination performance, with 100% accuracy for both calibration and prediction sets. The results demonstrated that optical fiber spectroscopy technology is an effective tool to fast detect the MC and freshness for loquats.
Longitudinal associations between Latine parents' support and their adolescents' science motivation and STEM career expectations
Authors: Puente Kayla , Simpkins Sandra D. , Eccles Jacquelynne Sue 
Published: April 2024

AbstractIntroductionParents' science support and adolescents' motivational beliefs are associated with adolescents' expectations for their future occupations; however, these associations have been mostly investigated among White, middle‐class samples. Framed by situated expectancy‐value theory, the current study investigated: (1) the associations between parents' science support in 9th grade and Latine adolescents' science intrinsic value, utility value, and STEM career expectations in 11th grade, and (2) whether these indicators and the relations among them differed by adolescents' gender and parents' education.MethodsStudy participants included Latine adolescents (n = 3060; Mage = 14.4 years old; 49% female) in the United States from the High School Longitudinal Study of 2009.ResultsAnalyses revealed a significant, positive association between parents' science support and Latine adolescents' science utility value. Additionally, there was a significant, positive association between parents' science support and Latinas' science intrinsic value, but not for Latinos' science intrinsic value. Latine adolescents' science utility value, but not their science intrinsic value, predicted their concurrent STEM career expectations. Though there were no significant mean level differences in adolescents' science utility value or parents' science support based on adolescents' gender, the measure of adolescents' science intrinsic value varied across girls and boys. Finally, adolescents whose parents had a college degree received greater science support from parents compared to adolescents whose parents had less education than a college degree.ConclusionFindings suggest parents' science support and adolescents' intrinsic and utility values have potential associations with Latine adolescents' STEM career expectations near the end of high school.
A comparative study of analytical models of diffuse reflectance in homogeneous biological tissues: Gelatin‐based phantoms and Monte Carlo experiments
Authors: Bahl Anisha , Segaud Silvere , Xie Yijing , Shapey Jonathan , Bergholt Mads S. , Vercauteren Tom 
Published: April 2024

AbstractInformation about tissue oxygen saturation (StO2) and other related important physiological parameters can be extracted from diffuse reflectance spectra measured through non‐contact imaging. Three analytical optical reflectance models for homogeneous, semi‐infinite, tissue have been proposed (Modified Beer–Lambert, Jacques 1999, Yudovsky 2009) but these have not been directly compared for tissue parameter extraction purposes. We compare these analytical models using Monte Carlo (MC) simulated diffuse reflectance spectra and controlled gelatin‐based phantoms with measured diffuse reflectance spectra and known ground truth composition parameters. The Yudovsky model performed best against MC simulations and measured spectra of tissue phantoms in terms of goodness of fit and parameter extraction accuracy followed closely by Jacques' model. In this study, Yudovsky's model appeared most robust; however, our results demonstrated that both Yudovsky and Jacques models are suitable for modeling tissue that can be approximated as a single, homogeneous, semi‐infinite slab.
The social side of color: How social exclusion influences preferences for color combination
Authors: Kwon Mijin , Jeon Eunmi , Han Youngjee 
Published: April 2024

AbstractThis study investigates the impact of social exclusion on consumer preferences for color combinations. Drawing on findings from five experimental studies, we demonstrate that individuals who have experienced social exclusion display a heightened preference for analogous color combinations, as opposed to complementary ones, compared to those who have not experienced social exclusion. Our research posits that this preference arises from the feeling of conflict induced by social exclusion, leading individuals to choose products and environments with analogous colors as a coping mechanism to alleviate this feeling of conflict. By establishing a connection between social exclusion and color combination preferences, our study contributes to a deeper comprehension of the factors influencing consumer choices in the realm of color. Furthermore, we demonstrate the broader consequences of social exclusion on consumer behavior. Our research also indicates that utilizing analogous color combinations in both product and interior design can substantially enhance the appeal for socially excluded individuals.
Motor behavior induced by bergamot essential oil in experimental tasks is differentially modulated by pretreatment with metabotropic glutamate receptor 2/3 or 5 antagonists
Authors: Rombolà Laura , De Rasis Enrica , Sakurada Shinobu , Sakurada Tsukasa , Corasaniti Maria Tiziana , Bagetta Giacinto , Scuteri Damiana , Morrone Luigi Antonio 
Published: April 2024

AbstractBergamot essential oil shows anxiolytic‐relaxant effects devoid of sedative action and motor impairment typical of benzodiazepines. Considering the potential for clinical of these effects, it is important to understand the underlying mechanisms of the phytocomplex. Modulation of glutamate group I and II metabotropic receptors is involved in stress and anxiety disorders, in cognition and emotions and increases locomotor activity and wakefulness. Interestingly, early data indicate that bergamot essential oil modulates glutamatergic transmission in specific manifestations of the central nervous system. The aim of this work is to investigate if selective antagonists of metabotropic glutamate 2/3 and 5 receptors affect behavioral parameters modulated by the phytocomplex. Male Wistar rats were used to measure behavioral parameters to correlate anxiety and motor activity using elevated plus maze (EPM), open field (OF), and rotarod tasks. Bergamot essential oil increases in EPM the time spent in open/closed arms and reduces total number of entries. The essential oil also increases immobility in EPM and OF and not affect motor coordination in rotarod. Pretreatment with the metabotropic glutamate antagonists does not affect the time spent in open/close arms, however, differently affects motor behavior measured after administration of phytocomplex. Particularly, glutamate 2/3 antagonist reverts immobility and glutamate 5 antagonist potentiates this parameter induced by the phytocomplex. Our data show that modulation of both metabotropic glutamate receptors is likely involved in some of behavioral effects of bergamot essential oil.
Comprehensive analysis of lung adenocarcinoma: Unveiling differential gene expression, survival‐linked genes, subtype stratification, and immune landscape implications
Authors: Xi Yong , Xi Liu , Tan Jian , Yu Chaoqun , Shen Weiyu , Yu Bentong 
Published: April 2024

AbstractThis study offers a detailed exploration of lung adenocarcinoma (LUAD), addressing its heterogeneity and treatment challenges through a multi‐faceted analysis that includes gene expression, genetic subtyping, pathway analysis, immune assessment, and drug sensitivity. It identifies 165 genes with significant expression differences and 46 genes associated with survival, revealing insights into oxidative stress and autophagy. LUAD samples were divided into three subtypes using consensus clustering on these 46 genes, with distinct survival outcomes. Gene Set Enrichment Analysis (GSEA) on HALLMARK gene sets indicated pathway variations with survival implications. The immune landscape, analyzed using the CIBERSORT algorithm, showed different immune cell distributions across subtypes, with the first subtype exhibiting a better immune environment and survival prospects. Advanced machine learning techniques developed a risk model from a set of four genes, effectively categorizing patients into high and low‐risk groups, validated through external datasets and analyses. This model linked lower risk scores to better clinical stages, with a higher mutation rate and potential immunotherapy benefits observed in the high‐risk group. Drug sensitivity assessments highlighted varied treatment responses between risk groups, suggesting avenues for personalized therapy. This comprehensive analysis enhances the understanding of LUAD's molecular and clinical nuances, offering valuable insights for tailored treatment approaches.
The rise and fall of water policy entrepreneurs in an unequal world
Authors: Muller Mike 
Published: April 2024

Highlights

Policy entrepreneurs from the ‘North’ had undue influence over water policy in the ‘South’ in previous decades.
Policy entrepreneurship in water must be centered in, rather than targeted at, the societies concerned.
‘Southern’ countries have gained greater autonomy over their water policies in a multi‐polar world and continue to offer opportunities for the international water industry.
Political leaders, administrators, and civil society in the South must now take responsibility and accountability for the outcomes.
It is now widely recognized that new infrastructure is essential to help mitigate and adapt to climate change and that hydropower is an energy transition ally not a climate change enemy.
The outcomes of laparoscopic omentum-preserving gastrectomy compared to open surgery with omentectomy in gastric cancer patients: a propensity score matched study of 249 UICC stage 0–IV gastric cancer patients
Authors: Jagric T. , Hladnik G. , Kolaric R. , Arpad I. , Horvat M. , Potrc S. 
Published: April 2024

Abstract
Background
We performed a propensity score matched study comparing patients’ short- and long-term results after laparoscopic omentum-preserving gastrectomy and open surgery with omentectomy with UICC stages 0–IV.

Methods
Between 2015 and 2022, 311 patients with gastric cancer underwent surgery at the University Clinical Centre Maribor. Of these, 249 met the inclusion criteria and 198 were included in the study group after PSM.

Results
Patients in both groups were well-balanced in demographic and pathological characteristics after PSM. There was no significant difference in the 5-year survival between groups (LAP: 62.2% vs. OPN: 54.4%; p = 0.950). The Cox regression model identified UICC stage and age as significant predictors for survival. In both groups, peritoneal dissemination was the most common site of recurrence. The multivariate analysis identified the UICC stage as a significant predictor for peritoneal recurrence, while omental preservation was not associated with a higher risk of peritoneal dissemination. Omentum preservation was not associated with more intestinal obstruction. Patients in the LAP group had significantly shorter hospital stays (LAP: 9(6) vs. OPN: 10(5); p = 0.009), less postoperative morbidity (LAP: 17% vs. OPN: 23.4%; p = 0.009), and significantly more extracted LNs per operation compared to open surgery (LAP: 31 ± 11 LNs vs. OPN: 25 ± 12 LNs; p = 0.002).

Conclusion
Based on our results, we recommend the use of laparoscopic omentum-preserving gastrectomy in patients with early and advanced gastric cancer.

Graphical abstract
Ecology and management of the coffee berry borer (Hypothenemus hampei): the potential of biological control
Authors: Moreno-Ramirez Natalia , Bianchi Felix J. J. A. , Manzano Maria R. , Dicke Marcel 
Published: April 2024

AbstractCoffee is an important commodity in Latin America that is grown by smallholder farmers and large-scale coffee producers. The coffee berry borer, Hypothenemus hampei Ferrari (Coleoptera: Curculionidae: Scolytinae) is a major pest of coffee that originates from West Africa and has invaded all coffee-producing regions. With climate change, the problems that this beetle poses to coffee production are expected to increase. Controlling this pest is a true challenge and chemical insecticides still are one of the main tools used, despite the environmental and human-health issues associated with this approach. To find sustainable alternatives for chemical control of the coffee berry borer, classical biological control, augmentative biological control, and integrated pest management have received extensive attention. Parasitoids, predators, entomopathogenic fungi, and nematodes have been identified and studied for their potential to manage the infestations of this major coffee pest. Conservation biological control has recently gained more attention, but its development is still in its infancy. In this review, we examine strategies for the control of the coffee berry borer in Latin America. We identify knowledge gaps for developing sustainable biological control programs, including conservation biological control within the context of farming systems, land use in the surrounding landscape, as well as the vision of coffee growers.