bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: A report from the glucosamine/chondroitin arthritis intervention trial
Authors: Sawitzke Allen D. , Shi Helen , Finco Martha F. , Dunlop Dorothy D. , Bingham Clifton O. , Harris Crystal L. , Singer Nora G. , Bradley John D. , Silver David , Jackson Christopher G. , Lane Nancy E. , Oddis Chester V. , Wolfe Fred , Lisse Jeffrey , Furst Daniel E. , Reda Domenic J. , Moskowitz Roland W. , Williams H. James , Clegg Daniel O. 
Published: September 2008

AbstractObjectiveOsteoarthritis (OA) of the knee causes significant morbidity and current medical treatment is limited to symptom relief, while therapies able to slow structural damage remain elusive. This study was undertaken to evaluate the effect of glucosamine and chondroitin sulfate (CS), alone or in combination, as well as celecoxib and placebo on progressive loss of joint space width (JSW) in patients with knee OA.MethodsA 24‐month, double‐blind, placebo‐controlled study, conducted at 9 sites in the United States as part of the Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT), enrolled 572 patients with knee OA who satisfied radiographic criteria (Kellgren/Lawrence [K/L] grade 2 or grade 3 changes and JSW of at least 2 mm at baseline). Patients with primarily lateral compartment narrowing at any time point were excluded. Patients who had been randomized to 1 of the 5 groups in the GAIT continued to receive glucosamine 500 mg 3 times daily, CS 400 mg 3 times daily, the combination of glucosamine and CS, celecoxib 200 mg daily, or placebo over 24 months. The minimum medial tibiofemoral JSW was measured at baseline, 12 months, and 24 months. The primary outcome measure was the mean change in JSW from baseline.ResultsThe mean JSW loss at 2 years in knees with OA in the placebo group, adjusted for design and clinical factors, was 0.166 mm. No statistically significant difference in mean JSW loss was observed in any treatment group compared with the placebo group. Treatment effects on K/L grade 2 knees, but not on K/L grade 3 knees, showed a trend toward improvement relative to the placebo group. The power of the study was diminished by the limited sample size, variance of JSW measurement, and a smaller than expected loss in JSW.ConclusionAt 2 years, no treatment achieved a predefined threshold of clinically important difference in JSW loss as compared with placebo. However, knees with K/L grade 2 radiographic OA appeared to have the greatest potential for modification by these treatments.
Family factors, emotional functioning, and functional impairment in juvenile fibromyalgia syndrome
Authors: Kashikar‐Zuck Susmita , Lynch Anne M. , Slater Shalonda , Graham T. Brent , Swain Nicole F. , Noll Robert B. 
Published: September 2008

AbstractObjectiveFamily factors and emotional functioning can play an important role in the ability of adolescents with juvenile primary fibromyalgia syndrome (JPFS) to cope with their condition and function in their everyday lives. The primary objectives of this study were to determine 1) whether adolescents with JPFS and their caregivers differed from healthy age‐matched comparison peers and their caregivers in terms of emotional distress and functional impairment; 2) whether there were any differences in the family environment of adolescents with JPFS compared with healthy comparison peers; and 3) which individual‐, caregiver‐, and family‐level variables were associated with functional impairment in adolescents with JPFS.MethodsParticipants were 47 adolescents with JPFS recruited from a pediatric rheumatology clinic and 46 comparison peers without chronic illness matched for age, sex, and race. Participants and their caregivers (all mothers) completed a battery of standardized measures administered in their homes.ResultsAdolescents with JPFS had greater internalizing and externalizing symptoms than healthy comparison peers. Mothers of adolescents with JPFS reported twice as many pain conditions and significantly greater depressive symptoms than mothers of comparison peers. The JPFS group also had poorer overall family functioning and more conflicted family relationships. In adolescents with JPFS, maternal pain history was associated with significantly higher functional impairment.ConclusionIncreased distress and chronic pain are evident in families of adolescents with JPFS, and family relationships are also impacted. Implications for child functional impairment and the need for inclusion of caregivers in treatment are discussed.
Activity limitations and compensatory mechanism use following limited wrist fusion
Authors: Bialocerkowski Andrea E. 
Published: September 2008

AbstractObjectiveTo document the activity limitations experienced by patients who had undergone a 4‐corner wrist fusion, and the compensatory mechanisms they use in daily life.MethodsPatients completed 2 copies of the Adelaide Questionnaire, a measure with a standardized section and an individualized section. The test–retest reliability of the questionnaire was evaluated.ResultsTwenty‐five patients were recruited to the study, and 21 completed both questionnaires. Excellent test–retest reliability was gained for both the standardized and individualized sections of the Adelaide Questionnaire.ConclusionPatients with 4‐corner wrist fusions report activity limitations following surgery, particularly with daily tasks that involve hand/forearm rotation and grip strength. Various compensatory mechanisms are used by the majority of patients. The impact of these mechanisms on activity limitations varies between patients, but often decreases impact of the activity limitations on everyday life.
Physical activity in adolescents with juvenile idiopathic arthritis
Authors: Lelieveld Otto T. H. M. , Armbrust Wineke , van Leeuwen Miek A. , Duppen Nienke , Geertzen Jan H. B. , Sauer Pieter J. J. , van Weert Ellen 
Published: September 2008

AbstractObjectiveTo explore physical activity (PA) in adolescents with juvenile idiopathic arthritis (JIA) compared with a healthy population and to examine associations between PA and disease‐related factors.MethodsTotal energy expenditure (TEE), activity‐related energy expenditure (AEE), PA level, and PA pattern were assessed with a 3‐day activity diary. Aerobic capacity was assessed using a Symptom Limited Bicycle Ergometry test. Functional ability was assessed with the Childhood Health Assessment Questionnaire. Disease activity was assessed using Paediatric Rheumatology International Trials Organisation core set criteria. Overall well‐being was measured using a visual analog scale, and time since diagnosis was assessed by retrospective study from patients' charts. We used a cross‐sectional study design. Reference data were collected from healthy Dutch secondary school children.ResultsThirty patients and 106 controls were included (mean ± SD age 17.0 ± 0.6 and 16.7 ± 0.9 years, respectively). TEE, AEE, and PA level were significantly lower in the JIA group. The JIA group spent more time in bed and less time on moderate to vigorous PA. Only 23% of the JIA patients met public health recommendations to perform ≥1 hour daily moderate to vigorous PA compared with 66% in the reference group. Higher PA was associated with higher levels of well‐being and maximal oxygen consumption.ConclusionAdolescents with JIA have low PA levels and are at risk of losing the benefits of PA. Low PA is not related to disease activity, and control over the disease does not restore previous PA levels. Interventions by pediatric rheumatologists are needed to increase PA levels in patients with JIA.
Living with a fluctuating illness of ankylosing spondylitis: A qualitative study
Authors: Mengshoel Anne Marit 
Published: September 2008

AbstractObjectiveTo examine the relationship between illness fluctuations and how people with ankylosing spondylitis (AS) adapt to everyday life situations.MethodsTwelve respondents, 8 women and 4 men, age 30–59 years with an AS duration of 6 months to 40 years participated in qualitative interviews. They were asked to give examples of how they lived their everyday life during good and bad times of illness. The text analyses consisted of familiarization with the content, identifying and coding meaningful statements, sorting them into categories, and condensing themes.ResultsThree different types of situations for those living with AS emerged from the analysis: ordinary life, slowed‐down life, and disrupted life. Ordinary life included managing symptoms by incorporating motion into everyday life routines and adjusting tasks in work situations, sports activities, home life, and social activities. During slowed‐down life, an acute or insidious onset of stiffness and fatigue occurred that could be reversed by slowing down ordinary life for a period of time. During disrupted life, the respondents were unable to cope with everyday life because of inexplicable and unmanageable intense, localized, or distributed pain.ConclusionBy examining the relationships between illness and what people do to recover, 3 different life conditions were found: ordinary life, slowed‐down life, and disrupted life. Living with AS requires a continuous but varying process of normalization of symptoms and everyday life within the framework of these 3 illness conditions.
Arthritis disability and heart disease disability
Authors: Verbrugge Lois M. , Juarez Lucia 
Published: September 2008

AbstractObjectiveArthritis is the most common health condition in midlife and late life, and heart disease is the leading cause of death. This article compares disability impacts of these 2 preeminent health problems.MethodsUsing data from the National Health Interview Survey Disability Supplement, we studied specific limitations and disabilities, accommodations used (buffers), and accommodations needed (barriers) for US population groups of adults with arthritis disability, heart disease disability, both arthritis and heart disease disability, and disability due to other conditions. Weights and complex SE adjusted for sample design. We hypothesized that arthritis disability is more extensive and troublesome than heart disease disability.ResultsPeople with arthritis disability had more numerous, longer, and more bothersome disabilities than people with heart disease disability. People with arthritis disability used more equipment and rehabilitation, whereas people with heart disease disability emphasized personal assistance, medications, and medical services. People with arthritis disability experienced more barriers and needs in activities and services. People with disabilities from both arthritis and heart disease were especially disadvantaged, with high levels of limitations and accommodations. People with disability from other conditions had the highest social participation, fewest disabilities, and most tailored accommodations of all groups.ConclusionArthritis had higher and more extensive disability impact than heart disease. Both groups had more difficulty, buffers, and barriers in their lives than people disabled by other conditions. Therefore, arthritis and heart disease are premier conditions for disability attention and alleviation in the US population.
Compliance with biologic therapies for rheumatoid arthritis: Do patient out‐of‐pocket payments matter?
Authors: Curkendall S. , Patel V. , Gleeson M. , Campbell R. S. , Zagari M. , Dubois R. 
Published: September 2008

AbstractObjectiveTo assess the impact of patient out‐of‐pocket (OOP) expenditures on adherence and persistence with biologics in patients with rheumatoid arthritis (RA).MethodsAn inception cohort of RA patients with pharmacy claims for etanercept or adalimumab during 2002–2004 was selected from an insurance claims database of self‐insured employer health plans (n = 2,285) in the US. Adherence was defined as medication possession ratio (MPR): the proportion of the 365 followup days covered by days supply. Persistence was determined using a survival analysis of therapy discontinuation during followup. Patient OOP cost was measured as the patient's coinsurance and copayments per week of therapy, and as the proportion of the total medication charges paid by the patient. Multivariate linear regression models of MPR and proportional hazards models of persistence were used to estimate the impact of cost, adjusting for insurance type and demographic and clinical variables.ResultsMean ± SD OOP expenditures averaged $7.84 ± $14.15 per week. Most patients (92%) paid less than $20 OOP for therapy/week. The mean ± SD MPR was 0.52 ± 0.31. Adherence significantly decreased with increased weekly OOP (coeff = −0.0035, P < 0.0001) and with a higher proportion of therapy costs paid by patients (coeff = −0.8794, P < 0.0001), translating into ∼1 week of therapy lost per $5.50 increase in weekly OOP. Patients whose weekly cost exceeded $50 were more likely to discontinue than patients with lower costs (hazard ratio 1.58, P < 0.001).ConclusionMost patients pay less than $20/week for biologics, but a small number have high OOP expenses, associated with lower medication compliance. The adverse impact of high OOP costs on adherence, persistence, and outcomes must be considered when making decisions about increasing copayments.
Feasibility and effectiveness of an aerobic exercise program in children with fibromyalgia: Results of a randomized controlled pilot trial
Authors: Stephens Samantha , Feldman Brian M. , Bradley Nicolette , Schneiderman Jane , Wright Virginia , Singh‐Grewal Davinder , Lefebvre Arlette , Benseler Susanne M. , Cameron Bonnie , Laxer Ronald , O'brien Christine , Schneider Rayfel , Silverman Earl , Spiegel Lynn , Stinson Jennifer , Tyrrell Pascal N. , Whitney Kristi , Tse Shirley M. L. 
Published: September 2008

AbstractObjectiveTo determine the feasibility of conducting a randomized controlled trial of a 12‐week exercise intervention in children with fibromyalgia (FM) and to explore the effectiveness of aerobic exercise on physical fitness, function, pain, FM symptoms, and quality of life (QOL).MethodsFM patients ages 8–18 years were randomized to a 12‐week exercise intervention of either aerobics or qigong. Both groups participated in 3 weekly training sessions. Program adherence and safety were monitored at each session. Data were collected at 3 testing sessions, 2 prior to and 1 after the intervention, and included FM symptoms, function, pain, QOL, and fitness measures.ResultsThirty patients participated in the trial. Twenty‐four patients completed the program; 4 patients dropped out prior to training and 2 dropped out of the aerobics program. Better adherence was reported in the aerobics group than in the qigong group (67% versus 61%). Significant improvements in physical function, functional capacity, QOL, and fatigue were observed in the aerobics group. Anaerobic function, tender point count, pain, and symptom severity improved similarly in both groups.ConclusionIt is feasible to conduct an exercise intervention trial in children with FM. Children with FM tolerate moderate‐intensity exercise without exacerbation of their disease. Significant improvements in physical function, FM symptoms, QOL, and pain were demonstrated in both exercise groups; the aerobics group performed better in several measures compared with the qigong group. Future studies may need larger sample sizes to confirm clinical improvement and to detect differences in fitness in childhood FM.
The ergonomic assessment tool for arthritis: Development and pilot testing
Authors: Backman Catherine L. , Village Judy , Lacaille Diane 
Published: September 2008

AbstractObjectiveErgonomic assessment and recommendations may help people with arthritis maintain employment; however, most ergonomic tools are designed to assess injury risk in the general population and are not specific to the needs of people with inflammatory arthritis (IA). Our objectives were to design and pilot test an ergonomic assessment tool for people with IA and to propose ergonomic modifications to prevent work loss and maintain at‐work productivity.MethodsRelevant content was identified in a literature review by an interdisciplinary team. Respecting some clients' reluctance to disclose arthritis to employers, no work site visit was required. An initial assessment tool was reviewed by a 4‐person expert panel, revised and pretested with 13 adults with IA by 3 occupational therapists (OTs). The final tool, comprised of a self‐assessment, an interview guide, and a solutions summary, was used in a pilot test of a multifaceted program designed to prevent work loss and maintain at‐work productivity. One OT conducted all ergonomic consultations and followed up with phone calls at 1 month. Implementation of recommendations was evaluated at 3, 6, and 12 months.ResultsNineteen women (mean age 51 years) with IA (mean disease duration 12 years) completed ergonomic assessments. A range of risks were identified and 87 recommendations were made (mean 4.5 per participant). At 1 year, 85% of recommendations had been implemented by 74% of the participants.ConclusionThe Ergonomic Assessment Tool for Arthritis is a feasible and comprehensive process for identifying ergonomic job accommodations.
Are behavioral interventions for arthritis effective with minorities? Addressing racial and ethnic diversity in disability and rehabilitation
Authors: McIlvane Jessica M. , Baker Tamara A. , Mingo Chivon A. , Haley William E. 
Published: September 2008

AbstractObjectiveTo determine whether research evaluating the effectiveness of behavioral interventions for arthritis demonstrates that these interventions are effective with, and appropriately utilized by, minority participants.MethodsA systematic review was conducted of arthritis intervention research from 1997 to 2008. For each article, information was gathered on the percentage of participants who were from different racial/ethnic groups, whether interventions were shown to be effective for minority participants, whether differential attrition analyses were conducted, whether efforts were reported in minority recruitment and retention, and whether attempts were made to make interventions culturally appropriate.ResultsWe identified 25 randomized intervention studies. Of these, only 2 reported on whether the intervention was similarly effective for white and black patients (equal effectiveness was found), and 6 studies reported examining differences in attrition by race (higher attrition in nonwhites was found in 1 study). Most studies did not report the percentage of participants from specific minority groups, and in many studies the percentage of minority participants was small. No studies reported making systematic efforts to assure that interventions were culturally appropriate for minority participants.ConclusionMinority patients with arthritis are at risk for higher levels of disability than white patients, but little is known about whether evidence‐based interventions for arthritis are effective for culturally diverse patients. In addition, minority patients appear to be underrepresented in intervention research, and too little attention has been paid to minority recruitment and assuring that interventions are culturally appropriate for diverse patients.
Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: A controlled analysis
Authors: Imamura Marta , Imamura Satiko Tomikawa , Kaziyama Helena H. S. , Targino Rosa Alves , Hsing Wu Tu , De Souza Luiz Paulo Marques , Cutait MArtin Mendonça , Fregni Felipe , Camanho Gilberto Luis 
Published: September 2008

AbstractObjectiveRefractory, disabling pain associated with knee osteoarthritis (OA) is usually treated with total knee replacement. However, pain in these patients might be associated with central nervous sensitization rather than peripheral inflammation and injury. We evaluated the presence of hyperalgesia in patients scheduled for a total knee replacement due to knee osteoarthritis with refractory pain, and we assessed the impact of pressure pain threshold measurements (PPT) on pain, disability, and quality of life of these patients.MethodsSixty‐two female patients were compared with 22 age‐matched healthy controls without reported pain for the last year. PPT was measured at the lower extremities subcutaneous dermatomes, over the vastus medialis, adductor longus, rectus femoris, vastus lateralis, tibialis anterior, peroneus longus, iliacus, quadratus lumborum and popliteus muscles and at the supraspinous ligaments from L1–L5, over the L5–S1 and S1–S2 sacral areas and at the pes anserinus bursae and patellar tendon.ResultsPatients with knee OA had significantly lower PPT over all evaluated structures versus healthy control subjects (P < 0.001). Lower PPT values were correlated with higher pain intensity, higher disability scores, and with poorer quality of life, except for the role‐emotional and general health status. Combined PPT values over the patellar tendon, at the S2 subcutaneous dermatome and at the adductor longus muscle were the best predictors for visual analog scale and Western Ontario and McMaster Universities Osteoarthritis Index pain scores.ConclusionPatients with pain due to osteoarthritis who were scheduled for total knee replacement showed hyperalgesia of nervous system origin that negatively impacted pain, knee functional capacity, and most aspects of quality of life.
The effect of cell fixation on the discrimination of normal and leukemia cells with laser tweezers Raman spectroscopy
Authors: Chan James W. , Taylor Douglas S. , Thompson Deanna L. 
Published: September 2008

AbstractLaser tweezers Raman spectroscopy (LTRS) was used to characterize the effect of different chemical fixation procedures on the Raman spectra of normal and leukemia cells. Individual unfixed, paraformaldehyde‐fixed, and methanol‐fixed normal and transformed lymphocytes from three different cell lines were analyzed with LTRS. When compared to the spectra of unfixed cells, the fixed cell spectra show clear, reproducible changes in the intensity of specific Raman markers commonly assigned to DNA, RNA, protein, and lipid vibrations (e.g. 785, 1230, 1305, 1660 cm−1) in mammalian cells, many of which are important markers that have been used to discriminate between normal and cancer lymphocytes. Statistical analyses of the Raman data and classification using principal component analysis and linear discriminant analysis indicate that methanol fixation induces a greater change in the Raman spectra than paraformaldehyde. In addition, we demonstrate that the spectral changes as a result of the fixation process have an adverse effect on the accurate Raman discrimination of the normal and cancer cells. The spectral artifacts created by the use of fixatives indicate that the method of cell preparation is an important parameter to consider when applying Raman spectroscopy to characterize, image, or differentiate between different fixed cell samples to avoid potential misinterpretation of the data. © 2008 Wiley Periodicals, Inc. Biopolymers 91: 132–139, 2009.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com