bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre‐study analytical method validation: comparison of four alternative approaches based on quality‐level estimation and tolerance intervals
Authors: Govaerts Bernadette , Dewé Walthère , Maumy Myriam , Boulanger Bruno 
Published: August 2008

AbstractIn industry and in laboratories, it is crucial to continuously control the validity of the analytical methods used to follow the products' quality characteristics. Validity must be assessed at two levels. The ‘pre‐study’ validation aims at demonstrating before use that the method will be able to achieve its objectives. The ‘in‐study’ validation is intended to verify, by inserting quality control (QC) samples in routine runs, that the method remains valid over time. At these two levels, the analytical method will be claimed valid if it is possible to prove that a sufficient proportion of analytical results is expected to lie within given acceptance limits [−λ,λ] around the nominal value. This paper presents and compares four approaches to checking the validity of a measurement method at the pre‐study level. They can be classified into two categories. In the first, a lower confidence bound for the estimated probability π of a result lying within the acceptance limits is computed and compared with a given acceptance level. Maximum likelihood and delta methods are used to estimate the quality level π and the corresponding estimator variance. Two approaches are then proposed to derive the confidence bound: the asymptotic maximum likelihood approach and a method proposed by Mee (Commun. Stat. Theory Methods 1988; 17(5):1465–1479). The second category of approaches checks whether a tolerance interval for hypothetical future measurements lies within the predefined acceptance limits [−λ,λ]. β‐expectation and β–γ‐content tolerance intervals are investigated and compared in this context. These four approaches are illustrated on a bioanalytical HPLC‐UV analytical process and compared through simulations. Copyright © 2008 John Wiley & Sons, Ltd.
Case‐based reasoning and the statistical challenges
Authors: Perner Petra 
Published: August 2008

AbstractCase‐based reasoning (CBR) solves problems using the already stored knowledge and captures new knowledge, making it immediately available for solving the next problem. Therefore, CBR can be seen as a method for problem solving and also as a method to capture new experience and make it immediately available for problem solving. The CBR paradigm has been originally introduced by the cognitive science community. The CBR community aims at developing computer models that follow this cognitive process. Up to now many successful computer systems have been established on the CBR paradigm for a wide range of real‐world problems. In this paper we will review the CBR process and the main topics within the CBR work. Hereby we try bridging between the concepts developed within the CBR community and the statistics community. The CBR topics we describe are similarity, memory organization, CBR learning and case‐base maintenance. Then we will review, based on applications, the open problems that need to be solved. The applications we focus on are meta‐learning for parameter selection, image interpretation, incremental prototype‐based classification and novelty detection and handling. Finally, we summarize our concept on CBR. Copyright © 2008 John Wiley & Sons, Ltd.
Recommendations on the use of Bayesian optimal designs for choice experiments
Authors: Kessels Roselinde , Jones Bradley , Goos Peter , Vandebroek Martina 
Published: August 2008

AbstractIn this paper, we argue that some of the prior parameter distributions used in the literature for the construction of Bayesian optimal designs are internally inconsistent. We provide practical advice on how to properly specify the prior parameter distribution. Also, we present an example to illustrate that Bayesian optimal designs generally outperform utility‐neutral optimal designs that are based on linear design principles. Copyright © 2008 John Wiley & Sons, Ltd.
A transmission capacity enhancement of the CDM‐based satellite DMB system
Authors: Lee Ho‐Jin , Lee In‐Ki , Chang Dae‐Ig , Kim Tae‐Hoon 
Published: August 2008

AbstractAfter the launch of Satellite Digital Multimedia Broadcasting (S‐DMB) service in Korea, there was a requirement to have more channels to accommodate more bandwidth‐requiring applications. We designed a new architecture to provide the system with more channel capacity while maintaining the current performance as much as possible. We took a hierarchical modulation technology used for the DVB‐S2 standard. A number of combinations of modulation parameters and FEC modes have been simulated for the evaluation of technical feasibility of the proposed structure. Also investigations were carried out to assess the impact to current service performance. It was found that a 16200‐bit LDPC with hierarchical modulation could give additional channel capacity while keeping the current quality of service for selected CODEC and code rates (Int. J. Satellite Commun. Networks 2004; 22). Though 1ldB degradation of BER to the existing service was resulted by this approach, but no perceptional service degradation was expected since current link margin is larger than 3ldB. We found that about 36% of capacity enhancement can be achievable by the hierarchical modulation with proper CODEC selection. Additional degradation, however, may be encountered in mobile environment due to the multipath channel in spite of its performance immunity to the Doppler effect. Copyright © 2008 John Wiley & Sons, Ltd.
Satellite digital multimedia mobile broadcasting (S‐DMB) system
Authors: Suenaga Masashi 
Published: August 2008

AbstractThe MBSAT spacecraft was lunched in March 2004 and has been in service for the world first satellite base multimedia service for mobile users in Japan and Korea. The service is based on the unique hybrid system named satellite digital multimedia mobile broadcasting (S‐DMB). The system consists of sophisticated high‐power satellite and ground base repeaters called gap filler (GF). The satellite MBSAT has unique features such as 12 m unfurlable mesh reflector antenna, the use of stationary plasma thruster for north–south stationkeeping and ring laser gyro for attitude control references. The MBSAT provides more than 57 dBW equivalent isotropic radiated power over Japan and Korea coverage area. The S‐DMB service has started using MBSAT in Japan and Korea. People can enjoy video, audio and data broadcasting services with mobile handy terminal in outdoor, in high‐speed moving vehicle, in commuter train and even in airplane. This system is also useful as an emergency media for disaster prevention such as tsunami warns or earthquake alarming. As S‐DMB is a flexible hybrid system, the service could be initiated by using only GF system in urban area. This approach enables launching mobile TV service fast and efficiently. Copyright © 2008 John Wiley & Sons, Ltd.
Two Novel Cobalt(II) Coordination Polymers Based on the Herbicide Glyphosate as a Building Block and their Magnetic Properties
Authors: Han Guang‐Fan , Luo Hui‐Zhou , Ye Qiong , Xiong Ren‐Gen 
Published: August 2008

AbstractThe hydrothermal reaction of glyphosate and Co(Ac)2·4H2O in the presence of water and ethanol at different temperatures affords two novel cobalt coordination polymers: C12H30N4O20P4Co (1) and C3H10NO7P1Co (2). Both structures were determined by single crystal X‐ray diffraction. The coordination polymer of 1 is a one‐dimensional chain polymer with the crystal data: $\rm P{\bar 1}$, a = 5.5010(7), b = 10.983(2), c = 11.381(2) Å, α = 69.848(2), β = 86.645(2)°, γ = 79.788(2), V = 634.6(2) Å3, Z = 1, R1 = 0.0548, wR2 = 0.1557, whereas the coordination polymer of 2 is a two‐dimensional layered polymer with the crystal data: $\rm P{\bar 1}$, a = 8.9669(7), b = 7.3670(5), c = 12.7577(9) Å, β = 101.433(2)°, V = 826.04(10) Å3 Z = 4, R1 = 0.0325, wR2 = 0.1125. The glyphosate ligand exhibits different coordination behaviors in these two coordination polymers. Research on magnetic behavior revealed an antiferromagnetic coupling interaction between the Co2+ ions in both compounds.
Syntheses and Structures of Organotin(IV) Thioesters of N‐Phthaloylamino Acids
Authors: Fard Zohreh Hassanzadeh , Müller Christian , Dehnen Stefanie 
Published: August 2008

AbstractFive organotin(IV) thioesters of N‐phthaloyl amino acids with the general formulae R3SnL (R = Me, Ph) and nBu2SnL2 were synthesized with L = N‐phthaloyl‐thioalanine and N‐phthaloyl‐thioleucine. The structures of trimethyltin(IV) N‐phthaloyl‐thioleucinate (1), trimethyltin(IV) N‐phthaloyl‐thioalaninate (2), triphenyltin(IV) N‐phthaloyl‐thioleucinate (3), triphenyltin(IV) N‐phthaloyl‐thioalaninate (4), and di‐n‐butyltin(IV) di‐N‐phthaloyl‐thioalaninate (5) were characterized by means of X‐ray diffractometry. Quantumchemical investigations served to clarify several structural peculiarities of the isolated compounds.
Drei Heterocubanartige (MII4O4)‐Typ Verbindungen (M = FeII, CoII, NiII)
Authors: Diewald S. , Lan Y. , Clérac R. , Powell A.‐K. , Feldmann C. 
Published: August 2008

AbstractBy reaction of MIICl2·x H2O (M = Fe (x = 4), Co, Ni (x = 6)) and LiOH·H2O in diethylene glycol (DEG) rod‐like crystals of the composition MII4Cl4(OCH2CH2OCH2CH2OH)4 are formed. According to X‐ray diffraction data obtained by both, single crystals and powders, the CoII and NiII compounds crystallize monoclinic with C2/c (CoII4Cl4(OCH2CH2OCH2CH2OH)4 (1): a = 2084.1(4), b = 919.0(2), c = 1754.0(4) pm, β = 124.3(1)°, Z = 4; NiII4Cl4(OCH2CH2OCH2CH2OH)4 (2): a = 2055.2(4), b = 932.1(2), c = 1727.4(4) pm, β = 125.2(1)°, Z = 4), whereas FeII4Cl4(OCH2CH2OCH2CH2OH)4 (3) crystallizes tetragonal with $\rm P{\bar 4}2_{1}c$ (a = 1251.4(2), c = 915.3(2) pm, Z = 2). All compounds exhibit analogous molecular structures which are built of a heterocubane‐type core consisting of four metal ions and four deprotonated oxygen atoms of four coordinated diethylene glycol molecules. Neutrality of charge is realized by additional coordination of four chloride anions. In addition to the structural characterization, the thermal and magnetical properties of the title compounds are investigated in detail.
Revealing the Crystal Structure of Anhydrous Calcium Oxalate, Ca[C2O4], by a Combination of Atomistic Simulation and Rietveld Refinement
Authors: Hochrein Oliver , Thomas Annu , Kniep Rüdiger 
Published: August 2008

AbstractThe existence of three different modifications of anhydrous calcium oxalate is reported since decades. Their crystal structures, however, remained unclear, yet. In the present work the crystal structure of the so‐called β‐modification was revealed by a combination of atomistic computer simulations and Rietveld refinements of the X‐ray powder pattern. No indication for polymorphism was obtained.
The Low and High Temperature Crystal Structures of [Mg(H2O)6]XBr3 Double Salts (X = Rb, Cs
Authors: Dinnebier Robert E. , Liebold‐Ribeiro Yvonne , Jansen Martin 
Published: August 2008

AbstractThe crystal structures of the alkali double salts [Mg(H2O)6]XBr3 (X = Rb+, Cs+) were analyzed in dependence on temperature from laboratory and synchrotron X‐ray powder diffraction data. At room temperature, both compounds are isostructural to [Mg(H2O)6](NH4)Br3 (C2/c; Z = 4; a = 9.64128(6) Å, b = 9.86531(5) Å, c = 13.78613(9) Å, β = 90.0875(5)° for [Mg(H2O)6]RbBr3; a = 9.82304(7) Å, b = 9.98043(6) Å, c = 14.0100(1) Å, β = 90.1430(4)° for [Mg(H2O)6]CsBr3). At a temperature of T = 358 K, [Mg(H2O)6]RbBr3 undergoes a reversible phase transition towards a cubic perovskite type of structure with the [Mg(H2O)6]2+ octahedron in the cuboctahedral cavity exhibiting 4‐fold disorder ($Pm{\bar 3}m$; a = 6.94198(1) Å at T = 458 K). In case of [Mg(H2O)6]CsBr3 the lattice parameters in dependence on temperature show a distinct kink at T = 340 K, but no symmetry breaking phase transition occurs before decomposition starts. The dominant role of hydrogen bonding with respect to the stability of the crystal structures is discussed.
Crystal Structure of the B‐type Dierbium Oxide ortho‐Oxosilicate Er2O[SiO4]
Authors: Phanon Delphine , Černý Radovan 
Published: August 2008

AbstractThe crystal structure of B‐type Er2O[SiO4] has been determined by single crystal X‐ray diffraction. It crystallizes with the (Mn,Fe)2[PO4]F type structure in the monoclinic space group C2/c (a = 14.366(2), b = 6.6976(6), c = 10.3633(16) Å, ß = 122.219(10)°, Z = 8) and shows anionic tetrahedral [SiO4]4– units and non‐silicon‐bonded O2– anions in distorted [OEr4]10+ tetrahedra. The [(Er1)O6+1] and [(Er2)O6] polyhedra form infinite chains which are connected by common edges.
New Transition‐Metal Borides containing Trigonal‐Planar B4‐Units: Syntheses and Single‐Crystal Structure Analyses of Ti1.6Os2.4B2 and Ti1–xFexOs2RhB2 (0 < x < 0.5)
Authors: Fokwa Boniface P. T. , Dronskowski Richard 
Published: August 2008

AbstractSingle crystals of Ti1.6Os2.4B2 and the solid solution Ti1–xFexOs2RhB2 (0 < x < 0.5) were synthesized by arc‐melting the elements in a water‐cooled copper crucible under an argon atmosphere. The new silver‐like phases, structurally characterized by single‐crystal X‐ray and EDX analyses, crystallize in the hexagonal Ti1.6Os1.4RuB2 structure type (space group $ P{\bar 6}2m$ (Nr. 189), Z = 3) and contain trigonal‐planar B4‐units and one‐dimensional chains of titanium or mixed titanium/iron atoms, respectively.
Tris(trifluoromethyl)borane Adducts of Cyanogen Halides
Authors: Geier Jens , Willner Helge 
Published: August 2008

AbstractThe reactivity of carbonyl‐tris(trifluoromethyl)borane (CF3)3BCO against the homologous series of cyanogen (pseudo)halides NCX, X = F, Cl, Br, I, CN, was investigated. Lewis acid‐base adducts (CF3)3BNCX were obtained for X = Cl, Br, I, CN and were characterized by vibrational and NMR spectroscopy. It appeared that FCN did not react and twofold complexation of NCCN does not occur, in agreement with theoretical complexation energies and QTAIM charges.
Biochemical and molecular diagnosis of erythropoietic protoporphyria in an Ashkenazi Jewish family
Authors: Schneider‐Yin X. , Mamet R. , Minder E. I. , Schoenfeld N. 
Published: August 2008

SummaryErythropoietic protoporphyria (EPP) is a rare hereditary disorder due to a partial deficiency of ferrochelatase (FECH). The genotype of EPP patients features a mutation on one allele of the FECH gene and a common hypomorphic FECH IVS3–48c on the other allele (M/c). The resulting enzyme activity in patients is ∼35% of that in normal individuals. Ferrochelatase deficiency results in the accumulation of protoporphyrin in the skin, which is responsible for the clinical symptom of cutaneous photosensitivity in patients. In this study, we report the identification of a novel FECH mutation delT23 in an 11‐member EPP family of Jewish origin. Two EPP siblings shared an identical genotype of delT23/IVS3–48c (M/c). They were both photosensitive and showed highly increased erythrocyte protoporphyrin. The genotype of the patients’ mother, who did not present with any EPP clinical symptoms, was delT23/IVS3–48t (M/t). The patients’ father, an offspring of consanguineous parents, was homozygous IVS3–48 c/c. He exhibited a mild photosensitivity, and an increase of 4‐fold in erythrocyte protoporphyrin. His FECH mRNA amount was 71% of that of genotype t/t. It is the first reported case of an individual with c/c genotype who exhibits both biochemical and clinical indications of EPP. These results suggest that IVS3–48c is a functional variant of ferrochelatase. The clinical symptoms and biochemical abnormalities in the patients’ father could be the result of an interaction between genetic and environmental factors. In addition, the frequency of IVS3–48c in the Ashkenazi Jewish population was estimated at 8%, which is similar to that in the European populations.
Efficiency and safety of oxcarbazepine in mood disorders: A naturalistic study exploring the interest of plasma dosages
Authors: Misdrahi David , Tournier Marie , Droulout Tiphaine , Grolleau Adeline , Titier Karine , Molimard Mathieu , Verdoux Helene 
Published: August 2008

AbstractObjectiveTo investigate whether measurement of plasma levels can predict tolerance to oxcarbazepine (OXC).MethodsWe reviewed medical records to identify all inpatients consecutively treated by OXC at the University Department of Psychiatry in Bordeaux. Adverse effects were rated before treatment onset, at day 3, then every week and at discharge or at discontinuation. Residual hydroxy-OXC concentrations were measured on blood samples at the same periods.ResultsOXC was prescribed to 20 patients with bipolar (n = 18) or schizoaffective bipolar-type disorder (n = 2). Reported side effects were transient and occurred mostly at the beginning of the treatment. Three patients stopped OXC because of severe cutaneous side effects. Residual hydroxy-OXC plasma levels were similar in patients with or without occurrence of side effects at all times of assessment.ConclusionOur data suggest that the occurrence of severe side-effects is relatively high with OXC. Measurement of plasma OXC levels does not appear to be of interest in clinical practice since plasma concentrations are not predictive of the occurrence of side effects.
Pelvic organ prolapse in rural Ghana
Authors: Wusu‐Ansah Osei K. , Opare‐Addo Henry S. 
Published: August 2008

AbstractObjectiveTo determine the prevalence of pelvic organ prolapse (POP) and its impact on the lives of women in Sekyidumasi, a rural Ghanaian community.MethodsA cross‐sectional study of 200 women was performed using a questionnaire and pelvic examination to detect symptoms and signs of prolapse. Main outcome measures were the presence of POP and its impact on quality of life.ResultsOut of 174 women included in the study, 21 women (12.07%) had POP. Seventeen of these women (81%) were symptomatic, of which only 6 women (35.3%) had sought treatment because of financial constraints. The odds of prolapse increased with increasing parity (P = 0.02) and age (P < 0.01). The main impacts of prolapse were on emotional well‐being (52.4%), the women's relationship with their partner (46.2%), and sex life (25%).ConclusionOnly about one‐third of women with symptomatic prolapse sought treatment because the cost of medical care outweighed the impact of the condition on their lives.
Serum leptin levels in overweight children and adolescents
Authors: Antunes Henedina , Santos Cristina , Carvalho Susana 
Published: August 2008

Leptin is an adipocyte-secreted hormone which plays a key role in energy homeostasis. Our aim was to determine the relationship between serum leptin and clinical and biochemical features in overweight children and adolescents. Overweight children and adolescents followed in this Unit with serum leptin ascertained were included. Clinical, biochemical and abdominal ultrasound data were analysed. Statistical analysis was performed byttest, χ2, Pearson's correlation and linear regression. One outlier of serum leptin was excluded to perform correlation and regression. Serum leptin was determined in 357 patients. At the first visit, the mean age was 9·5 (sd3·2) years and mean BMIz-score was 1·72 (sd1·34) (girls 1·71 (sd1·16); boys 1·72 (sd1·11)). Serum leptin levels were significantly related to: sex (mean: girls 48·0 ng/ml, boys 34·4 ng/ml;P = 0·003); Tanner stage (mean: I–II 37·0 ng/ml, III–V 45·2 ng/ml;P = 0·035); systolic blood pressure (mean: normal 41·3 ng/ml, high 44·0 ng/ml;P = 0·009); BMIz-score (r0·136;P = 0·010); C-peptide (r0·17;P = 0·002); insulin (r0·34;P < 0·001); homeostasis model assessment of insulin resistance (HOMA-IR) (r0·25;P < 0·001) and aspartate aminotransferase (r− 0·12;P = 0·023). In the multivariate analysis (with leptin as the dependent variable and sex, Tanner stage, BMIz-score, systolic blood pressure, aspartate aminotransferase, C-peptide, insulin and HOMA-IR as independent variables), sex and BMI were determinant factors. The present study in overweight children and adolescents showed that being female and greater BMI were significantly and independently associated with increased serum leptin. In this large cohort other associations with leptin described in the literature can be discharged.
Helminth communities of the autochthonous mustelids Mustela lutreola and M. putorius and the introduced Mustela vison in south-western France
Authors: Torres J. , Miquel J. , Fournier P. , Fournier-Chambrillon C. , Liberge M. , Fons R. , Feliu C. 
Published: August 2008

AbstractThis study presents the first comprehensive helminthological data on three sympatric riparian mustelids (the European mink Mustela lutreola, the polecat M. putorius and the American mink M. vison) in south-western France. One hundred and twenty-four specimens (45 M. lutreola, 37 M. putorius and 42 M. vison) from eight French departments were analysed. Globally, 15 helminth species were detected: Troglotrema acutum, Pseudamphistomum truncatum, Euryhelmis squamula, Euparyphium melis and Ascocotyle sp. (Trematoda), Taenia tenuicollis (Cestoda), Eucoleus aerophilus, Pearsonema plica, Aonchotheca putorii, Strongyloides mustelorum, Molineus patens, Crenosoma melesi, Filaroides martis and Skrjabingylus nasicola (Nematoda) and larval stages of Centrorhynchus species (Acanthocephala). The autochthonous European mink harboured the highest species richness (13 species) followed by the polecat with 11 species. The introduced American mink presented the most depauperate helminth community (nine species). The prevalence and worm burden of most of the helminths found in M. putorius and M. lutreola were also higher than those of M. vison. Some characteristics of their helminth communities were compared to relatively nearby populations (Spain) and other very distant populations (Belarus). This comparison emphasized M. patens as the most frequent parasite in all of the analysed mustelid populations. It was possible to conclude that the invasive M. vison contributes to the maintenance of the life cycle of the pathogenic T. acutum and S. nasicola helminths, with possible implications for the conservation of the endangered European mink.
StatAlign: an extendable software package for joint Bayesian estimation of alignments and evolutionary trees
Authors: Novák Ádám , Miklós István , Lyngsø Rune , Hein Jotun 
Published: August 2008

Abstract
Motivation: Bayesian analysis is one of the most popular methods in phylogenetic inference. The most commonly used methods fix a single multiple alignment and consider only substitutions as phylogenetically informative mutations, though alignments and phylogenies should be inferred jointly as insertions and deletions also carry informative signals. Methods addressing these issues have been developed only recently and there has not been so far a user-friendly program with a graphical interface that implements these methods.
Results: We have developed an extendable software package in the Java programming language that samples from the joint posterior distribution of phylogenies, alignments and evolutionary parameters by applying the Markov chain Monte Carlo method. The package also offers tools for efficient on-the-fly summarization of the results. It has a graphical interface to configure, start and supervise the analysis, to track the status of the Markov chain and to save the results. The background model for insertions and deletions can be combined with any substitution model. It is easy to add new substitution models to the software package as plugins. The samples from the Markov chain can be summarized in several ways, and new postprocessing plugins may also be installed.
Availability: The code is available from http://phylogeny-cafe.elte.hu/StatAlign/
Contact: miklosi@ramet.elte.hu