bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dialyl-sulfide with chalcone prevent breast cancer prohibiting SULT1E1 malregulations and oxidant-stress induced HIF1a-MMPs induction
Authors: Nazmeen Aarifa , Maiti Sayantani , Maiti Smarajit 
Published: March 2024

Abstract
Background: In some breast cancers, decreased estrogen-sulfotransferase (SULT1E1) and its inactivation caused by oxidative-stress lead to elevated E2 levels as well as hypoxia-inducible tissue-damaging factors.
Methods: Here, matrix-metalloproteases (MMP2/9) activity and SULT1E1-HIF1α protein/gene expression (Western-blot/RTPCR) were assessed in human breast-cancers versus their adjacent-tissues. Oxidant-stress neutralizer, chalcone (α,β unsaturated ketone) and SULT1E1-inducer pure vdialyl-sulfide (source garlic; Allium sativum) were tested to prevent cancer causing factors in rat, in-vitro and in-vivo model. The antioxidant-enzymres SOD1, catalase, GPx and LDH, and matrix-degenerating MMP2/9 activities were assessed (gel-zymogram). Histoarchitecture (HE-staining) and tissue SULT1E1-localization (immuno-histochemistry) were screened. Extensive statistical-analysis were performed.
Results: Human cancer-tissue expresses higher SULT1E1, paralleling HIF1α protein/mRNA owing to lower LDH activity. In addition, increase of MMP2/9 activities commenced tissue damage. However, chalcone and DAS significantly induced SULT1E1 gene/protein, and suppressed HIF1α expression, and MMP2/9 activities in rat tissues. Correlation of individual parameter statistics and group statistics of t-test suggest significant correlation of oxidative-stress (MDA) with SULT1E1 (p=0.006), HIF1α (p=0.006) protein-expression. The non-protein-thiols showed a negative correlation (p=0.001) with HIF1α. These two proteins and SULT1E1 mRNA expressions in human breast tumor were significantly higher (p<0.05) compared to the adjacent tissues. Pearson correlation data suggest, SULT1E1 is correlated with non-protein-thiols in different exposure groups.
Conclusions: Breast cancers associate with SULT1E1, HIF1α and MMPs deregulations. We are reporting for the first time that higher SULT1E1-protein in advanced cancer, remain inactive in oxidative environment and may be re-activated in chalcone induced reducing-state. Moreover, DAS induced SULT1E1 mRNA expression augments its protein synthesis. Synergistic drug-effects commenced HIF1α and MMPs suppression. Further studies are necessary.
Ethnic disparities and lifestyle determinants in the prevalence of cardiovascular disease among Han majority and Ha Ni ethnic minority older adults in rural Southwest China
Authors: HUANG You , LI Qin , ZUO Mei , LIU Lan , LI Guo-hui , CAI Le 
Published: March 2024

Abstract

Objectives
Cardiovascular disease (CVD) is the leading cause of death in China. To provide evidence for preventing and controlling the development of CVD among older adults in ethnic minority communities by understanding the ethnic disparities and lifestyle determinants of CVD. This study aimed to compare ethnic disparities and lifestyle determinants in the prevalence of CVD (hypertension, CHD, and stroke) among older adults between Han majority and Ha Ni ethnic minority in rural southwest China.
Methods
A cross-sectional questionnaire and physical examination were conducted among Han majority and Ha Ni ethnic minority groups aged ≥ 60 years in rural Southwest China. Height, weight, waist circumference and blood pressure values of each participant were recorded. The relationship between ethnic and lifestyle factors and CVD was analyzed using multivariate logistic regression.
Results
A total of 1413 Han majority and 1402 Ha Ni ethnic minority elderly individuals participated in this study. Han majority older adults had a higher prevalence of CHD and stroke than in Ha Ni ethnic minority counterparts (P < 0.01). Compared with the Han majority elderly, Ha Ni ethnic minority older adults had a higher risk of hypertension (OR = 1.168, 95%CI: 1.070–1.274), and a lower risk of CHD (OR = 0.818, 95%CI: 0.680–0.985) and stroke (OR = 0.736, 95%CI: 0.605–0.895). Participants with obesity were more likely to have hypertension (OR = 2.092, 95%CI: 1.344–3.255) and CHD (OR = 2.259, 95%CI: 1.341–3.808). Additionally, those who with central obesity and physically inactivity were more likely to have hypertension (OR = 2.349, 95%CI: 1.930–2.858 and OR = 1.303, 95%CI: 1.105–1.537) and stroke (OR = 2.205, 95%CI: 1.384–2.962 and OR = 2.024, 95%CI: 1.405–2.916). Current drinking increased the risk of hypertension (OR = 1.311, 95%CI: 1.077–1.596), but decreased the risk of stroke (OR = 0.428, 95%CI: 0.243–0.754).
Conclusion
CHD and stroke are more prevalent among the Han majority older adults in rural Southwest China, and there is a significant influence of lifestyle factors on CVD.
Multimodal Representation and Cross Modal Enhancement for Short Video Recommendation
Authors: Jae-won Song , Yoo-jin Kang , Min-seok Jang 
Published: March 2024

Abstract
The surge in short video content production on various platforms has marked the emergence of short videos as a new and popular form of media. However, the sheer abundance and complexity of short video data present challenges for effective video recommendation. Short videos encapsulate rich multimodal information across both temporal and spatial dimensions, allowing users to engage with videos in various ways—whether focusing on the content of a particular shot, delving into the storyline, or enjoying the accompanying music. Conventional video recommendation systems typically focus on a singular type of recommended content, providing recommendations for entire videos, which may not fully satisfy the nuanced preferences of users. In multimodal data, each modality contributes specific information to the others, establishing correlations between them. In the context of video data, which combines image, speech, and text data, understanding the relationships among these three media types is crucial for effective multimodal content-based video recommendation. In this paper, we leverage the consistency of multimodal features for understanding multimedia content, aiming to derive a robust representation from the inherent characteristics of short videos. Unlike previous studies that primarily concentrate on a single modality in short video recommendation, our approach capitalizes on the multimodality of short video content and adopts a multimodal recommendation strategy. By extracting and fusing information from multiple modalities, we achieve a more comprehensive short video content analysis, paving the way for our recommendation method.
Deciphering omics atlases to aid stony corals in response to global change
Authors: He Chunpeng , Han Tingyu , Huang Wanlong , Wang Bing , Liao Xin , Chen J.-Y. , Lu Zuhong 
Published: March 2024

Abstract
Coral reefs are rapidly declining due to global climate change1. Alongside environmental protection, gene engineering technologies are essential in protecting reef-building (stony) corals2-7. Precise multi-omics backgrounds are crucial for gene technique application8-13 and understanding stony coral biology2-5. However, high heterozygosity4,14 and exogenous sequence contamination15-17 impede high-quality stony coral genome assembly. To address this, we developed a workflow for stony coral genome assembly, achieving four high-quality chromosome-level genomes (Acropora muricata, Montipora foliosa, M. capricornis, and Pocillopora verrucosa). A global synteny analysis of chromosomes and homeobox genes highlighted the highly conserved features of Scleractinia stony coral genomes, even after an evolutionary divergence 250 million years ago (mya). Single-cell RNA sequencing (scRNA-seq), combined with a pan-genomic analysis, aided our understanding of symbiosis and calcification, both issues of conservation concern. A dynamics simulation of the mechanism of systemic RNA interference defective protein 1 transmembrane family member 1 (SIDT1) tetramer offered a potential approach to observe gene impacts on stony corals. This work enhances understanding of the evolutionary, molecular, and cellular aspects of stony corals and provides a detailed dataset for applying gene engineering technologies in response to global climate challenges.
Integrating Protein Structure Prediction and Bayesian Optimization for Peptide Design
Authors: Xu Dong 
Published: March 2024

Abstract
Peptide design, with the goal of identifying peptides possessing unique biological properties, stands as a crucial challenge in peptide-based drug discovery. While traditional and computational methods have made significant strides, they often encounter hurdles due to the complexities and costs of laboratory experiments. Recent advancements in deep learning and Bayesian Optimization have paved the way for innovative research in this domain. In this context, our study presents a novel approach that effectively combines protein structure prediction with Bayesian Optimization for peptide design. By applying carefully designed objective functions, we guide and enhance the optimization trajectory for new peptide sequences. Benchmarked against multiple native structures, our methodology is tailored to generate new peptides to their optimal potential biological properties.
Gene expression biomarkers differentiate overall survival of colorectal cancer upon targeted therapies
Authors: Yazdani Akram , Yazdani Azam , Mendez-Giraldez Raul , Pillonetto Gianluigi , Samiei Esmat , Hadi Reza , Lenz Heinz-Josef , Venook Alan , Samiei Ahmad , Nixon Andrew ,   Joseph Lucci 3rd, Kopetz Scott , Bertagnolli Monica , Perou Charles , Innocenti Federico 
Published: March 2024

Abstract

While monoclonal antibody-based targeted therapies have substantially improved progression-free survival in cancer patients, the variability in individual responses poses a significant challenge in patient care. Therefore, identifying cancer subtypes and their associated biomarkers is required for assigning effective treatment. In this study, we integrated genotype and pre-treatment tissue RNA-seq data and identified biomarkers causally associated with the overall survival (OS) of colorectal cancer (CRC) patients treated with either cetuximab or bevacizumab. We performed enrichment analysis for specific consensus molecular subtypes (CMS) of colorectal cancer and evaluated differential expression of identified genes using paired tumor and normal tissue from an external cohort. In addition, we replicated the causal effect of these genes on OS using validation cohort and assessed their association with the Cancer Genome Atlas Program data as an external cohort. One of the replicated findings was WDR62, whose overexpression shortened OS of patients treated with cetuximab. Enrichment of its over expression in CMS1 and low expression in CMS4 suggests that patients with CMS4 subtype may drive greater benefit from cetuximab. In summary, this study highlights the importance of integrating different omics data for identifying promising biomarkers specific to a treatment or a cancer subtype.
A case of metacarpal coloboma caused by Tumor-induced Osteomalacia treated with bone cement prosthesis and literature review
Authors: Huang Chuanhong , Dong Panfeng , Chen Yueping , Chen Shangtong 
Published: March 2024

Abstract
Tumor-induced osteomalacia (TIO) is a rare disease known as hypophosphoric osteomalacia (HO). Phosphaturic mesenchymal tumor (PMT) is the pathological basis of most TIO patients and is caused by abnormal secretion of fibroblast growth factor 23 (Fibroblast Growth Factor 23, PMT). FGF-23 causes abnormal renal phosphate consumption and hypophosphatemia and is often subject to repeated examination and treatment before diagnosis, and the process of definitive diagnosis usually lasts several years. Most of these patients can be cured by surgical resection of the tumor, but the tumor causing this disease is often small in size, hidden in location, and difficult to detect. Multiple examination methods are needed to determine the location of the tumor, and cases of complete bone loss caused by direct tumor erosion have not been reported in the literature. We report a case in which the third metacarpal bone was lost due to direct tumor erosion, which was treated with prostheses made of bone cement. We also reviewed the relevant literature to explore the diagnosis of tumor-related osteomalacia and the treatment strategy used for this extremely rare case.
A case report of Inguinal Endometriosis-A rare entity of a common condition
Authors: Rodrigo Nilan 
Published: March 2024

Abstract
Background: This case report discusses the presentation, diagnostic challenges, and successful surgical management of inguinal endometriosis(IEM).
Case presentation: A 46-year-old Sinhalese woman experienced a painful lump in the right groin area for 5 years, with exacerbation during menstruation, coughing, and sneezing. Initial treatment, with depot methylprednisolone acetate injection, was ineffective. Two years later, at a different hospital, an endometriotic mass was identified in the right inguinal region, excision was not performed because of the propensity for vascular injury instead three doses of depot medroxyprogesterone acetate(DMPA) significantly alleviated the pain. When she presented to our hospital, a provisional diagnosis of right inguinal endometriosis was made after an ultrasound examination. A multidisciplinary approach involving a surgeon was employed for excision surgery, with meticulous attention given to avoiding femoral vein injury. The 45x25x25 mm mass, located in the inguinal ligament, was successfully removed.
Conclusion: This case underscores the importance of collaboration between specialties for accurate diagnosis and effective surgical management of inguinal endometriosis. Preoperative imaging is useful, but the final diagnosis can be confirmed only after surgical excision and histopathology
Advanced Key Expansion Algorithm Using a High-Performance Four-Dimensional Chaotic Map and a Strong S-Box for Enhanced Sensitivity and Independence
Authors: Li Yuxuan 
Published: March 2024

Abstract
The round key is pivotal to the integrity of block encryption algorithms, derived from the initial key via the key expansion process to enhance security measures. This study introduces an innovative key expansion algorithm, underpinned by a high-performance four-dimensional chaotic map and a durable S-box, distinguishing itself through key sensitivity and independence, thereby enhancing defense against diverse cryptographic attacks. We debut a four-dimensional chaotic map, lauded for its exceptional dynamic qualities as evidenced through rigorous behavior analysis. Furthermore, we develop an S-box generation method utilizing operations in the finite field GF(28), producing an S-box characterized by its high nonlinearity and fortified security. This S-box is meticulously designed to avoid common vulnerabilities such as fixed points, reverse fixed points, and brief periods, rendering it ideal for key expansion purposes. Leveraging the strengths of the chaotic map and S-box, we detail our key expansion algorithm and validate its security efficacy through comprehensive analysis, highlighting its potential as a robust tool in cryptographic security.
Evaluation of Turbo expander technologies for FLNG
Authors: Chan We Lin 
Published: March 2024

Abstract
The global increase in carbon emission is one factor in using clean fuels to minimise air pollution by avoiding fossil fuel usage in the marine sector. The current effort of changing the energy source to LNG fossil gas fuel was assumed to be the cleanest fuel due to lower carbon emission to ease the rapid growth of carbon emission. Recent development in the LNG market drives the shipyard industry to build the LNG offshore platform FLNG, which is like the LNG plant with no land base but offshore. The LNG marine industry forecasts that increasing demand for FLNG vessels will accelerate the de-velopment of gas resources, research work on the system process analysis and optimisation of the Liquefaction system. The rapid growth in equipment and processes of FLNG development is the response to weight and space limits challenges. This paper describes the optimisation process of LNG turboexpander technologies’ benefits based on the different pro-cesses. Since the Single Nitrogen Expander that less efficiency and irreversible losses, another consideration of the dual expander process models and comparison from the simple model to the complex expander process. This article will focus on the LNG liquefaction research process results and analyses the design and optimisation based on power consumption, LNG production and future research directions of FLNG. This research is to aid in a small-scale liquefaction process with a refrigerant cycle proposed in this study to meet these FLNG challenges. The research methodology is to study all models of the expander liquefaction process and analyse the differential pressure of natural gas entry to vary the temperature, heat flow, exergy, and enthalpy. The Aspen Plus and Hysys simulator used a state-of-the-art run simulation for processes for all models.
Esports Physical Exercise/Performance Matrix 1.0 Country Factsheets: A Protocol for National, Regional and Global Annual Assessment
Authors: Long Bo , AGUDAMU AGUDAMU , Matic Radenko , Popovic Stevo , Bu Te 
Published: March 2024

Abstract

This protocol was developed to allow evaluators to collect up-to-date data and produce a comprehensive annual assessment through several specific indicators and ensure the outcomes that include the most relevant evidence about physical activity/exercise for esports players from each country and recognition of particular barriers for physical activity/exercise. For this reason, this manuscript aims to create a methodology that will provide a better basis for establishing a standardized monitoring system on physical exercise and performance in esports players at national and regional levels as well as globally. This study protocol proposed 20 sociodemographic indicators that are available online and it will be compiled to identify the characteristics of the participating countries and describe country's demographic profile. On the other hand, this protocol proposed nine content indicators that were singled out for the assessment of physical exercise and performance in esports players. To evaluate each of the content indicators, a separate analysis has to be conducted, and a ten-point grading scale will be employed. This study protocol will initiate the national evaluators (researchers) to meet annually to produce national reports (the Country Factsheets) that will ensure effective and dynamic linkages between research and practice.
ON HISTORY OF TRUTHFUL BIOGRAPHY — THE FIRST ANTHOLOGY OF TRANSLATIONS OF MODERN CHINESE PROSE INTO RUSSIAN LANGUAGE
Authors:   St. Petersburg State University, Rodionov Alexey 
Published: March 2024

The paper involves archival materials, scientific literature and the information system of the Beijing Lu Xun Museum to examine the history of the preparation and circumstances of the publication of the first collection of translations of modern Chinese prose into Russian — Truthful Biography. Novellas and Stories of Modern China published by the Molodaya gvardiya Publishing House in 1929. The author concludes that the publication of the collection Truthful Biography was a logical result of the attention of the Soviet Union to the China engulfed by the revolution. Shortcomings in the translation of literary texts reflect not only the insufficient level of Chinese language proficiency among some translators, but also the lack of traditions and norms of translation of modern Chinese literature in the Soviet Union in the late 1920s. Nevertheless, the collection Truthful Biography. Novellas and Stories of Modern China can be considered a starting point in the translation of modern Chinese literature into Russian and the beginning of the involvement of specialists in modern China in the Soviet Union in the study of Chinese literature.	en_GB
Safety Issues of Herb-Warfarin Interactions
Authors: Hazra Subhajit , Singh Preet Amol , Bajwa Neha 
Published: March 2024

Abstract:
Warfarin is a popular anticoagulant with high global demand. However, studies have underlined serious
safety issues when warfarin is consumed concomitantly with herbs or its formulations. This review
aimed to highlight the mechanisms behind herb-warfarin interactions while laying special emphasis on its PKPD
interactions and evidence on Herb-Warfarin Interaction (HWI) with regards to three different scenarios,
such as when warfarin is consumed with herbs, taken as foods or prescribed as medicine, or when used in special
situations. A targeted literature methodology involving different scientific databases was adopted for acquiring
information on the subject of HWIs. Results of the present study revealed some of the fatal consequences
of HWI, including post-operative bleeding, thrombosis, subarachnoid hemorrhage, and subdural hematomas
occurring as a result of interactions between warfarin and herbs or commonly associated food products
from Hypericum perforatum, Zingiber officinale, Vaccinium oxycoccos, Citrus paradisi, and Punica
granatum. In terms of PK-PD parameters, herbs, such as Coptis chinensis Franch. and Phellodendron
amurense Rupr., were found to compete with warfarin for binding with plasma proteins, leading to an increase
in free warfarin levels in the bloodstream, resulting in its augmented antithrombic effect. Besides, HWIs were
also found to decrease International Normalised Ratio (INR) levels following the consumption of Persea americana
or avocado. Therefore, there is an urgent need for an up-to-date interaction database to educate patients
and healthcare providers on these interactions, besides promoting the adoption of novel technologies, such as
natural language processing, by healthcare professionals to guide them in making informed decisions to avoid
HWIs.
Ginsenoside Rb1 Inhibits the Proliferation of Lung Cancer Cells by Inducing the
Mitochondrial-mediated Apoptosis Pathway
Authors: Feng Lin , Liu Xinze , Sun Kaijing , Sun Ying , Wu Wei , Chen Changbao , Jin Xin , Wan Xilin 
Published: March 2024

Background:
Lung cancer is one of the more common malignant tumors posing a great threat to human
life, and it is very urgent to find safe and effective therapeutic drugs. The antitumor effect of ginsenosides has
been reported to be a treatment with a strong effect and a high safety profile.

Objective:
This paper aimed to investigate the inhibitory effect of ginsenoside Rb1 on 95D and NCI-H460 lung
cancer cells and its pathway to promote apoptosis.

Methods:
We performed the CCK-8 assay, fluorescence staining assay, flow cytometry, scratch healing assay, and
Transwell assay to detect the effects of different concentrations of ginsenoside Rb1 on the antitumor activity of
95D and NCI-H460 cells and Western Blot detected the mechanism of antitumor effect.

Results:
Ginsenoside Rb1 treatment significantly increased the inhibition and apoptosis rates of 95D and NCIH460
cells and inhibited the cell cycle transition from S phase to G2/M. Rb1 induces apoptosis by altering the
levels of P53, Bax, Cyto-c, Caspase-8, Caspase-3, Cleaved Caspase-3, Bcl-2, MMP-2, and MMP-9 proteins and
activating the external apoptotic pathway.

Conclusion:
Ginsenoside Rb1 inhibits proliferation and migration and induces apoptosis of 95D and NCI-H460
lung cancer cells by regulating the mitochondrial apoptotic pathway to achieve antitumor activity.