bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptional profile features in patients with early and late preeclampsia
Authors: Kotelnikova V. E.A. , Pantyukhova D. E. , Ablyamitova F. D. , Vikinskaya S. N. , Khalilova Kh. U. , Mustafaeva L. F. , Barieva D. A. , Yarovaya D. V. , Chopik N. D. , Ermakova M. S. , Sorokina L. E. 
Published: March 2024

Aim: to assess the molecular mechanisms in developing various clinical phenotypes of preeclampsia (PE) by analyzing specific placental tissue transcriptome patterns. Materials and Methods. The prospective observational comparative study in parallel groups enrolled 43 pregnant women divided into 2 groups: main group – 23 pregnant women with diagnosed PE and control group – 20 apparently healthy women with uncomplicated pregnancy course, delivery and the postpartum period. To examine PE phenotypic features, the main group of pregnant women with PE was subsequently divided into 2 subgroups according to the date of pathology onset: early (n = 10) and late (n = 13) PE. Using the whole-genome next-generation sequencing (NGS), a comparative analysis of altered 18 microRNA level in placental tissue was carried out. Results. Pregnant women with early PE compared to the control group were characterized by significantly low expression level for hsa-miR-656-3p (p < 0.001), hsa-miR-323a-5p (p = 0.017), hsa-miR-519c-3p (p = 0.019), hsa-let-7i-5p (p = 0.019), hsa-miR-433-3p (p = 0.019), hsa-let-7g-5p (p = 0.030), hsa-miR-214-5p (p = 0.030), hsa-miR-27a-5p (p = 0.031), hsa-miR-339-5p (p = 0.041), hsa-miR-524-5p (p = 0.045), hsa-miR-1283 (p = 0.049) and high expression for hsa-miR-151a-5p (p = 0.007), hsa-miR-4521 (p = 0.018), hsa-miR-30d-5p (p = 0.026), hsa-miR-548l (p = 0.027), hsa-miR-133b (p = 0.034), hsa-miR-424-5p (p = 0.042), hsa-miR-211-5p (p = 0.049). Patients with late PE had significantly decreased expression for hsa-miR-656-3p (p = 0.050) andhsa-miR-574-3p (p = 0.017) as well as a significantly higher for hsa-miR-211-5p (p = 0.001) compared to the control group. Subgroup of women with early vs. late onset PE was characterized by significantly decreased expression level for hsa-miR-323-5p (p = 0.007) and overexpressed hsa-miR-30d-5p (p = 0.002), hsa-miR-5481 (p = 0.027). Conclusion. The noted multidirectional expression for some microRNAs in subgroups of PE patients confirms the validity for stratification of such pathology based on two distinct phenotypic manifestations (early and late forms) and indicates the existence of different pathophysiological vectors in PE formation.
The impact of bariatric surgery on female reproductive health
Authors: Chigisheva E. Kh. , Batyrshin I. I. , Sarvalieva A. F. , Khalitova I. V. , Zhuk T. M. , Evdokimova L. V. , Akbulatova M. A. , Zolotareva Ya. R. , Zainysheva L. M. , Baloyan S. , Dragunova E. M. , Korenkova A. A. , Bilyal N. A. , Sergeev Yu. P. 
Published: March 2024

Introduction. Obesity is a worldwide problem at epidemic scale. Bariatric surgery (BS) is the most effective method to treat morbid obesity characterized by long-term and positive effects on concomitant diseases. However, the effect of BS on female reproductive health has not been sufficiently studied to date, which makes relevant to conduct further investigations in this field. Aim: to summarize research data assessing BS effect on female reproductive health. Materials and Methods. There was conducted a search for publications in the electronic databases PubMed, eLibrary and Google Scholar to identify the following keywords and their combinations in Russian and English: "bariatric surgery", "reproductive health", "sex hormones", "pregnancy", "menstrual cycle", "fetal", "neonatal". The evaluation of the articles was carried out in accordance with the PRISMA recommendations. Based on search data, 868 publications from PubMed, 83 publications from eLibrary and 74 publications from Google Scholar were retrieved. After the selection procedure, 79 articles were included in the review. Results. To date, the data regarding the long-term BS effects on improved obesity-related endocrine disorders remain insufficient. It is better to recommend long-acting reversible contraceptives such as intrauterine device, to post-BS patients. Women with BS history should have a continuous comprehensive nutritional assessment as well as blood macronutrients and trace elements monitoring before, during and after pregnancy. Recognizing potential complications associated with BS in the anamnesis and timely seeking specialized medical aid or timely transfer of a patient to a specialized medical facility may improve pregnancy outcomes for a mother and paired newborn. Conclusion. While making decision to perform BS, it is necessary to fully understand its impact on female reproductive health, assess patients' reproductive intentions and fulfill health education obligations. All patients of childbearing age who are candidates for BS should participate in a joint decision-making dialogue on BS-related risks and benefits for reproductive health, which should be supported by extensive multidisciplinary work involving obstetricians, gynecologists, endocrinologists, psychologists and representatives of other medical specialties. To date, the data regarding the BS-related effects on pregnant women are heterogeneous, which requires additional investigations in this field.
Physicians’ Adherence to Clinical Guidelines on the Chronic Heart Failure Diagnosis and Treatment: Changes Over 2 Years of the Document’s Existence
Authors: Perepech N. B. , Tregubov A. V. , Mikhailova I. E. 
Published: March 2024

Aim. To study how physicians’ commitment to the basic provisions of clinical guidelines (CGs) for the diagnosis and treatment of chronic heart failure (CHF) has changed over the two years of the document existence.Material and methods. An anonymous survey was performed for 263 physicians (204 cardiologists, 46 internists and 13 other specialists) who were trained in advanced training programs in 2022. The questionnaire included questions regarding self-assessment of the respondents’ professional knowledge, their attitude to the role of CGs in everyday practice and ideas about methods for treatment of CHF.Results. Respondents gave 60.6 % correct answers to questions related to the treatment of CHF. More than 70% correct answers were given by 42.7% of cardiologists and 17.4% of internists. Compared to 2020, the proportion of cardiologists who gave more than 70 % correct answers increased significantly (p<0.05). CGs were considered mandatory by 26.2% and important or sometimes useful by 71.5% of respondents. Cardiologists considered CGs mandatory more frequently than internists (29.9 and 15.2 %, respectively; p=0.04). The mean number of correct answers was greater in the subgroup of respondents who considered CGs mandatory (p<0.001). More than 70% correct answers were given by only 43.8% of cardiologists, who considered themselves fully informed and able to advise colleagues on complex issues of diagnosis and treatment of CHF, and 40.6% of physicians who considered their knowledge acceptable for managing patients with CHF.Conclusion. The majority of physician consider CGs an important methodological document but only a little more than 25 % are aware that CGs are mandatory. Cardiologists are better informed than internists about the principal provisions of National Clinical Guidelines for the diagnosis and treatment of CHF, but the average level of physician knowledge remains low.
Pengolahan Citra Radiograf Panoramik Pada Deteksi Filling Gigi Manusia
Authors: Asti Ayu Nurul , Passarela Rossi , Sutarno Sutarno 
Published: March 2024

Dengan pemrosesan citra gigi yang muncul pada kasus identifikasi manusia dalam ilmu pengetahuan forensic seperti citra X-ray gigi telah membantu secara efektif untuk mendiagnosis dan mendeteksi masalah di gigi. Pada penelitian ini akan melakukan pendekatan untuk mendeteksi filling gigi (tambal gigi) pada karies gigi di Xray Panoramik. Peningkatan dan segmentasi citra x-ray gigi digital dilakukan dengan menggunakan deteksi tepi robert. Tujuan dari ini adalah untuk meningkatkan bagian gigi yang diekstraksi dari digital rontgen gigi, menemukan tepi yang sesuai dengan gigi yang terkena tambal(filling). Proses mengekstraksi fitur, mengumpulkan dan menganalisis informasi gambar yang diharapkan dapat berguna untuk klinis diagnostik gigi dan juga merupakan kebutuhan utama ilmu kedokteran dan lainnya. Dalam penelitian ini didapatkan persentase dari dataset program bahwa akurasi terindikasinya filling gigi yaitu 87,93%, nilai presisi 88,7% dan nilai sensitiviti sebesar 96,6% dari 116 data yang diuji.
Abu-Sahl al-Masihi (960-1010 AD) and His Description of the Heart
Authors: Taghavi-Shirazi Maryam , Aghabeiglooei Zahra , Ghods Roshanak , Hashem-Dabaghian Fataneh 
Published: March 2024

Since the Old Testament era, medicine has drawn scientists from around the world. Persian physicians have played an undeniable role in the advancement of medicine worldwide and their books have been taught as medical textbooks in the East and the West for years. In the Islamic Golden Age (9th to 12th century AD), Abu-Sahl al-Masihi (960-1010 AD), was one of the great Persian scholars contemporary to Avicenna and Al-Biruni. He wrote several valuable works on medicine, philosophy, mathematics, and astronomy in Arabic. The two books titled Al-Mia fil-Tibb (Book of the Hundred [on Medicine]) and Ezhar al-Hekmat Allah Ta’ala fi Khalgh al-Ensan (Manifestations of God’s Wisdom in the Creation of Mankind) also known as Tashrih Badan al-Ensan (Human Anatomy) are among his important works in medicine. Particularly, in Tashrih Badan al-Ensan, Abu-Sahl detailed the structure and function of each organ within the human body. On heart anatomy, he presented interesting, and even innovative views. Despite the significance of his views on medicine among physicians of the Islamic era, his works have failed to be translated into Latin or other languages for unknown reasons, leaving him veiled in academic spheres. This paper aims to describe Abu-Sahl al-Masihi's opinions on heart anatomy.
The Best Practice of Marketing Management in Polish and International Enterprises
Authors: Golik-Górecka Grażyna , Grzegorczyk Wojciech , Gwiaździński Emilian , Wadlewski Aron-Axel , Krawiec Wioletta , Olejniczak Aneta , Sibińska Anna , Dąbrowski Jacek , Fabicka Wioletta , Michałus Małgorzata , Skonieczka Oliwia , Selinah Mabena Maimoona , Diaz Riaño Geraldine Tatiana 
Published: March 2024

Książka stanowi prezentację teoretycznych założeń dobrych i najlepszych praktyk zarządzania marketingowego oraz przykładów ich implementacji w biznesie. Dobrane przykłady stanowią ilustrację aktualnych wyzwań, jakie stoją przed organizacjami polskimi i międzynarodowymi, a także odpowiedzi organizacji for profit i non profit, które mogą stanowić wzór do naśladowania dla innych podmiotów. Publikacja stanowi kontynuację podręcznika wydanego pod redakcją Grażyny Golik-Góreckiej pod tytułem Mariaż nauki z praktyką. Najlepsze praktyki zarządzania marketingowego w polskich i międzynarodowych przedsiębiorstwach. Studia przypadków (Wyd. UŁ, Łódź 2020). Niniejszy podręcznik powstał dzięki współpracy pracowników naukowych z Katedry Marketingu na Wydziale Zarządzania Uniwersytetu Łódzkiego, praktyków biznesu oraz byłych już studentów programów Erasmus i Mobility, którzy uczestniczyli w warsztatach „Marketing Management in Practice” na Wydziale Zarządzania UŁ.
GEOTECNOLOGIAS NA DIFUSÃO DE CONHECIMENTO SOBRE MUDANÇAS CLIMÁTICAS NO ENSINO SUPERIOR
Authors: Rodrigues Rocha Angélica , Wachholz Flávio , Aquino Maia Samara 
Published: March 2024

A temática de Mudanças Climáticas retornou ao centro das discussões dos grandes encontros entre líderes, tomadores de decisões e sociedade civil. O sensoriamento remoto se enquadra como uma ferramenta indispensável nos estudos relacionados ao agravamento e aceleramento dos processos de mudanças climáticas e seus impactos em níveis locais, regionais e global. O objetivo deste trabalho foi apresentar uma sequência didática e aplicar ferramentas tecnológicas no ensino de sensoriamento remoto em turmas do curso de Geografia da Universidade do Estado do Amazonas. A metodologia consistiu na elaboração de uma dinâmica em formato de aula interativa. A aula foi dividida em três blocos: I) Diagnóstico Situacional; II) Conceitos sobre Mudanças Climáticas e Sensoriamento remoto e a integração entre as temáticas e II) Aplicação de Geotecnologias. As ferramentas geotecnológicas utilizadas foram o Google Earth Engine, Maquete virtual e em Realidade Aumentada. A dinâmica do ponto de vista dos aplicadores aconteceu na maior parte do tempo como previsto no plano de ensino, no entanto, devido ao tempo limitado algumas etapas precisaram ser aplicadas em velocidade mais acelerada do que o ideal. A resposta das turmas foi muito receptiva a inserção da temática de Mudanças Climáticas, especialmente quando inserida junto à assuntos de sua familiaridade e que compõe a grade curricular, com 74% dos estudantes se sentindo muito interessado no aprofundamento dos estudos ao final da dinâmica.
Age-dependent Robust Strategic Asset Allocation with Inflation-Deflation Hedging Demand
Authors: Kusuda Koji , Kikuchi Kentaro 
Published: March 2024

Abstract
This study analyzes robust strategic asset allocation under a quadratic security market model with stochastic volatility and inflation rates assuming ``age-dependent robust utility'' in which relative ambiguity aversion is a decreasing function of age. We show that, unlike homothetic robust utility, age-dependent robust utility cannot be interpreted as homothetic stochastic differential utility. We consider the finite-time consumption-investment problem and derive a linear approximate optimal robust portfolio candidate decomposed into myopic, intertemporal hedging, and inflation-deflation hedging demands. Our numerical analysis of the approximate optimal allocation to the S\&P500 shows modest hump-shaped age effects, similar to the results of a previous empirical analysis, and that the upswing is due to the increase in myopic demand, while the downswing is due to the decrease in intertemporal hedging demand.
Association of First Report of Botryosphaeria Spp. With Almond Dieback and Gummosis in Türki̇ye
Authors: endes ali 
Published: March 2024

Abstract

Türkiye is among the top-producing almond countries in the world. Almond is a precious nut in modern diets due to its bioactive compounds associated with health and disease treatment. However, the plant's yield is affected by factors, including pathogens. This study aimed to diagnose and identify biotic factors associated with decline, dieback, and gummosis in almond trees in Yozgat province with a temperate climate. Seven almond 10-year orchards were investigated and trees with symptoms were sampled. Isolated species were cultured in PDA medium to identify the morphological and cultural characterization. The results obtained with cultural and morphological characteristics along with Phylogenetic analysis of ITS, β-tubulin, and EF-1α sequence data, confirmed the presence of Diplodia seriata, Lasiodiplodia theobromae, Neofusicoccum parvum, Botryosphaeria dothidea. Among these species, Botryosphaeria dothidea was first reported from almond trees in Türkiye. Pathogenicity testing showed that although all species were virulent, L. theobromae and N. parvum isolates caused more gumming in the inoculation areas than D. seriata and B. dothidea isolates. These results confirm that multiple Botryosphaeriaceae species are associated with branch decline and dieback on almond in Türkiye, which agrees with similar studies on woody crops. Accurate diagnosis of fungal pathogens in almonds is vital for developing disease management strategies and may help improve horticultural practices in maintaining urban stands.
Do Caregivers Have an Effect on Extended Hospitalization in Patient-Fallowed Palliative Care Center? A Study from Turkey.
Authors: Çakmak Nuray Yılmaz , Bozkuş Rıfat 
Published: March 2024

Abstract
Objective: Since palliative care clinics are clinics that strive to solve the pain caused by the disease as well as other physical and psychological symptoms and social problems as a caregiver burden, the length of stay becomes important in our clinics with high demand from patients.
One of the purposes of palliative care centers is to evaluate the patient for discharge, to provide devices that the patient needs at home or in a nursing home, and to provide caregivers with care and device usage training. We aimed to investigate whether the length of stay is caused by the caregivers as well as clinical conditions.
Material and Methods: In this study, we retrospectively investigated the days of hospitalization of 915 patients followed in a palliative care center and the factors that prolong hospitalization in patients with extended hospitalization.
Results: The average length of stay of the patients was found to be 15.65±11.43 days. Hospitalization longer than 28 days was found to be 97(10.60%) patients. The most common reason for extended hospitalization was the reluctance of caregivers to discuss discharge in 47 (48.45%) patients. The second most frequent discharge was delayed in 25 (25.8%) patients due to clinical instability. 23(23.71%). A significant relationship was detected between length of stay and TPN nutrition. A significant relationship was detected between patients with cancer (P:0.042) and coronary artery disease (P<0.01) on extended stay.
Conclusion: With the aging of the world population and the improvement of health care services, the need for palliative care is increasing daily. In order to use resources efficiently, there is a need to optimize the length of stay in palliative care with a multidisciplinary approach.
Trial registration
This study registered retrospectively.
WITHDRAWN: Effect of unsaturated flow on the occurrence and movement of light nonaqueous phase fluids
Authors: Zhao Guizhang , Cheng Jiale , Li Leicheng , Liu Yu , Zhang Hongli , Li Hongliang , Zhang Hepeng 
Published: March 2024

Abstract
The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Substance Use Patterns and Negative Urine Opioid Screen Among Patients on Methadone Treatment at a Referral Hospital in Nairobi, Kenya.
Authors: Kuria Susan Wangeci 
Published: March 2024

Abstract

BackgroundStudies show concurrent substance use is common among patients with opioid use disorder. Despite evidence that various medications for Opioid Use Disorder are beneficial, some patients continue using opioids while in the program. We aimed to determine substance use patterns at enrolment and negative urine opioid screens among patients who were attending the Medically Assisted Therapy Clinic at a referral hospital in Nairobi.MethodsThis was a retrospective cohort study of 713 patients who had enrolled in the Medically Assisted Therapy clinic between December 2014 and February 2018. Data for each participant was collected over 24 months. A researcher-designed socio-demographic form and a data collection form were used to collect data. The data was analysed using Statistical Analysis for Data Science (STATA) version 18. 3.10.ResultsMost participants were male 85.7%, with a mean age of 34.3 years (SD 8.6). The majority had primary and below level of education 48.8%, were employed 59.5%, and were single/separated/widowed 78.4%. All the participants had used at least one other substance apart from opioids. The most common substances were; tobacco 91%, followed by cannabis 82.9% and benzodiazepines 51.5%. At 6, 12, 18, and 24 months, negative urine opioid screens were 61.3%, 76.0%, 73.5%, and 81.4%, respectively. At 24 months, 81.3% of the participants were still active in treatment.ConclusionsMany of the patients attending the Medically Assisted Therapy clinic use more than one substance. There is a need to scale up the program to also offer free management for other substances. Many patients had a negative urine opioid screen at 24 months; this replicated the evidence for the efficacy of medications for Opioid Use Disorders. However, there is a need to further explore why some patients continue to use opioids while in the program.
FIRE Stones:Impact of forced diuresis on the residual fragment rate after flexible ureteroscopy for destruction of kidney stones with laser: protocol for a randomized controlled two-parallel group multicenter trial with blinding evaluation.
Authors: Letouche Marie-Lou , Giraudeau Bruno , AGIER Marie-Sarah , Bruyere Franck 
Published: March 2024

Abstract
Background
Lithiasis is a common and recurrent disease. Flexible ureteroscopy (fURS) is the cornerstone of laser treatment of kidney stones. Kidney stones destruction requires its laser pulverization into small fragments in order to remove them through the ureter or improve their spontaneous expulsion along the urinary tract. However, most of the time, all the micro-fragments and dust created cannot be extracted using our surgical tools, and may stay intra-renally at the end of the procedure. Adjuvant treatments (such as forced diuresis, inversion or mechanical pressure) were previously described to improve the expulsion of stone fragments after extra-corporeal shock wave lithotripsy. Nevertheless, the impact of adjuvant treatment after fURS remains unclear and mainly theoretical.
Objective
The primary objective is to show that the injection of 40 mg of Furosemide in slow intravenous during 10 minutes, after the procedure, increases the stone-free rate 3 months after a fURS for destruction of kidney stones with laser.
Methods/design
The study will be a two-parallel group randomized, controlled, multicentric trial with a blinding evaluation. Nine French departments of urology will participate. Patients will be randomized in 2 groups: the experimental group (injection of 40mg of Furosemide at the end of the surgery) and a control one (usual care). Patients will be followed up for 3 months (+/- 2 weeks) after the surgery. Then, we will perform a low dose abdomino-pelvic CT-scan. The primary outcome is the stone-free rate at 3 months. A centralized review of the images will be performed by two specialized radiologists, in a blind and crossed way to allow a homogenization of the results. The secondary outcomes will include the rate of early post-operative urinary tract infection (UTI), the evaluation of post-operative pain and the safety of the use of Furosemide in patients treated by fURS for renal stone laser destruction. As secondary objectives, it is also planned to look at the effect of the prescription of an alpha-blocker as usual treatment on stone-free rate, and to assess the agreement between the imaging analysis of the urologist and the specialized radiologist.
Discussion
Lithiasis is a public health problem. It affects about 10% of the general population. This prevalence is increasing (multiplied by 3 in 40 years), partly due to changes in the population's eating habits over the years. The lithiasis patient is a patient with a chronic disease requiring annual follow-up and who may suffer from multiple recurrences, with a recurrence rate at 5 years of 50%.
Trial registration
ClinicalTrials.gov Identifier: NCT05916963, first received: 22 June 2023. https://clinicaltrials.gov/study/NCT05916963
EU Clinical Trials Register EudraCT Number: 2022-502890-40-00.