bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Intramuscular Iron‐dextran Complex on Iron‐deficiency Anaemia in Otherwise Ill Infants and Pre‐school Children1
Authors: LANZKOWSKZY PHILIP 
Published: January 2008

Summary1. One hundred and twenty‐five ill infants and children who were found to have iron‐deficiency anaemia were treated with in tramuscular iron‐dextran complex with doses varying from 100 to 400 mg, con‐current with treatment for the presenting illness.2. The mean haemoglobin levels before treatment ranged from 8.91 g%to 9.61 g%in the various age groups; at 3 weeks after the injection of iron the mean haemoglobin levels were found to range between 10.12 g%and 10.80 g%and at 6 weeks after injection the mean haemoglobin levels had risen further to range between 10.75 g%and 12.0 g%. There was thus an approximate general rise of 2 g %of haemoglobin in 6 weeks. Clinically the beneficial effects were quite striking, and occurred often within days.3. The results of this investigation indicate that intramuscular iron‐dextran complex can significantly raise the haemoglobin level in infants and children who have iron‐deficiency anaemia with a variety of associated illnesses, of all degrees of severity, and of largely undetermined duration. In addition, iron‐dextran complex was found to be safe and easy to administer.4. The factors influencing rate of recovery from iron‐deficiency anaemia after in tramuscular iron‐dextran complex, the theoretical dangers of iron overload and the possible production of sarcomata in iron‐injected tissue are discussed.
A Study of Group A Hemolytic Streptococcus Carriers Among School Children:
Authors: MOZZICONACCI P. , GERBEAUX CL. , CARAVANO R. , GERBEAUX S. , LABONDE J. , RAHMAN S. , RABCYNSKA F. , ORSSAUD E. , VIROLLEAU P. 
Published: January 2008

SummaryIn the course of a study pursued for 2 consecutive years in normal children of a suburban public school of the Paris area, the following findings were noted: (1) when the technique used was sufficiently sensitive, the rate of healthy carriers was relatively high: 16.7%on an average, with a range of 6.7%to 30%. (2) this percentage seemed to present variations during the course of the year which are perhaps due to a seasonal factor. (3) the cumulative percentage was such that at the end of two years more than one subject in two was found, to have been a carrier of hemolytic streptococci a t least once. (4) there was no correlation between the rate of carriers and the development of clinical infections (septic sore throat, scarlet fever). (5) the subjects fell into 4 groups: refractory subjects, occasional carriers, prolonged carriers of the same strain, prolonged carriers of different strains. (6) a “prolonged carrier”) factor was found to exist statistically, i.e. certain subjects were particularly receptive to the Group A hemolytic streptococcus, or conversely, certain subjects were refractory. (7) within the scope of our study this factor was found together with various to, her independent correlations. Of these, the correlations with the presence of tonsils and with bad conditions of hygiene (absence of running water in the child's home) were hardly surprising; that with a genetic factor (dark iris) was more unexpected, but has been established on equally as sound a basis.
Aortic Thrombosis and Aortic Medionecrosis in an Infant
Authors: MOBERG ANDERS 
Published: January 2008

SummaryIn the literature 24 cases of aortic thrombosis in children have been described of which 11 patients have been less than 3 weeks old. A case is described with a large thrombus in the abdominal aorta of a 16 day old boy. Thrombi were also discovered in the ductus arteriosus, the umbilical artery, the left ventricle and the left auricle. Histological examination of the aortic wall revealed changes of the type that are usually seen in aortic medionecrosis. It is presumed that in accordance with similar cases of aortic medionecrosis the thrombosis and the medionecrosis are directly connected. The etiology is discussed. This case, like a few previously published cases of aortic medionecrosis in the neonatal period, indicates that the disease is of a congenital origin.
Sensitivity of Listeria Monocytogenes in vitro to Different Antibiotics and Chemotherapeutics
Authors: NYSTRÖM K. G. , KARLSSON K.‐A. 
Published: January 2008

SummaryThe sensitivity of 14 antibiotics and chemotherapeutics to 86 strains of Listeria monocytogenes isolated from 15 animal species was studied by means of an agar diffusion technique. The tetracyclines (chlortetracycline, oxytetracycline, tetra‐cycline), erythromycin and streptomycin proved to be clearly superior to other antibiotics tested in vitro.No difference in resistance was found referable to the species of animal from which the strains emanated.
The Vitamin B1, B2 and C Content in Urine of Premature and Fullterm Newborn Infants
Authors: DAHL M. , MARKKANEN T. , VANHA‐PERTTULA T. 
Published: January 2008

SummaryThe daily excretion of vitamins B1, B2, and C was studied in 24 newborn full‐term infants during the three first days of life, and in 15 premature infants on three successive days of treatment. No correlation was observed between the mothers' state of health during pregnancy, the number of previous births and the presence of certain diseases, with the daily excretion of vitamin B1, B2 and C in the urine of newborn full‐term infants.
Hereditary Renal Dysplasia and Blindness
Authors: LØKEN AAGOT CHRISTIE , HANSSEN ODD , HALVORSEN SVERRE , JØLSTER NIELS JOHAN 
Published: January 2008

SummaryTwo siblings, a boy and a girl, with congenital blindness died at 8 and 9 years of age from renal failure. Autopsy was performed in one case. The kidneys showed evidence of dysplasia and of pyelonephritis. Earlier suggestions that renal dysplasia might be the primary cause in cases of chronic pyelonephritis in children are supported. Examination of the eyes indicated a congential defect, retinal aplasia.
Respiratory Studies in Children
Authors: GEUBELLE F. , RUDDER P. DE 
Published: January 2008

SummaryThe functional residual capacity (VFRc) was measured in ten normal adults and 23 normal children (11 girls and 12 boys), ranging in age from 6‐15 years by a closed circuit method with helium as the test gas. Three assays, with some hours' to severa1 days' interval, have shown a day‐to‐day variation of about ±6% in the three groups (±7.5% for the adults, ±3.7% for the boys and ±5.8% for the girls).
Clinodactyly and Brachymesophalangia of the Fifth Finger
Authors: ROCHE A. F. 
Published: January 2008

Summary1. Serial radiographs of the hands of 192 mongoloid and 120 normal children extending over four years have been used to investigate the frequency of clinodactyly and brachymesophalangia in the fifth finger and their changes during growth.2. The incidence of clinodactyly in the mongoloid children was similar to that recorded in the literature but the incidence in the normal children was higher than that recorded previously. Clinodactyly with a middle phalanx of the usual length occurred with almost equal frequency in both mongoloid and normal children. There was a marked difference between the two groups of children in the incidence of clinodactyly associated with brachymesophalangia.3. It is suggested that brachymesophalangia is a more important physical sign mongolism than clinodactyly. Considering children under the age of 8 years, it was present in 25.0%of the mongoloid group and 3.3%of the normal group and was almost always associated with clinodactyly.4. The incidence of clinodactyly did not vary with age but brachymesophalangh was slightly less common among older mongoloids.
Successful Resuscitation of Two Immature Infants with Cardiac Arrest During Exchange Transfusion
Authors: WALLGREN GÖRAN , OKMIAN LUDVIG 
Published: January 2008

SummaryTwo instances of asystolic cardiac arrest in immature infants during exchange transfusions are reported. In both cases the collapse came as an unexpected complication at the end of the transfusion. When extrathoracic manipulations to restore spontaneous heart action had been unsuccessfully performed for one and two minutes respectively, thoracotomy was performed and cardiac massage instituted. Spontaneous heart action started in one case shortly after manual compressions three months respectively. Methods to institute cardiac action are discussed and it is stressed that thoracotomy and cardiac massage are comparatively easy procedures not contraindicated by the small size of these infants. The use of continuous ECG control during exchange transfusion is recommended.
Ley dig Cell Tumour of the Testis in a 63 Year Old Boy
Authors: MOE PETER JOHAN , IVERSEN OLAV HILMAR 
Published: January 2008

SummaryA case of Leydig cell tumour in a 6 ½ year‐old boy is presented. The need for more elaborate methods for the biochemical separation of Leydig cell tumour from aberrant adreno‐cortical tissue is stressed. Normal urinary output of Preganetriol and a lack of increase of the 17‐beta‐ketosteroids in the urine in a patient with a tumour in one of the testes serve to exclude the possibility of an adreno‐cortical disorder.
The Adrenocortical Function in Children Preliminary Report
Authors: SALMI Toivo , PEKKARINEN AIMO , HEIKKILÅ. SAARA 
Published: January 2008

SUMMARYThe basal excretion of total 17‐hydroxycorticosteroids has been studied in urine altogether in 141 children from infants to 15 years of age and the adrenocortical reserve during a 2 days intramuscular ACTH‐test of 0.55 units of depot‐ACTH (Acton prolongatum. Nordiska Hormonlaboratoriet, Malmo) per kilogram of body weight twice daily in 63 children.During the first and second days of life 1.0–1.1 mg of 17‐OHCS are excreted. The basal excretion diminishes during the first month and increases during the first year. At the age of 4–6 years it is 3.7 mg. At the age of 7–10 years the basal excretion can reach the level of adults, 5 mg.The excretion of 17‐OHCS of ACTH‐days during the first month is almost three to four times and at the age of 1–4 years two to three times the basal excretion. The adrenocortical reserve in children increases with the age remarkably clearly as early as in the 4–6 year old children and approximately follows the length curve of children. In the group of 4–6 years the average excretion is during the first ACTH‐day 8.6 mg and the second ACTH‐day 14.1 mg, clearly bigger than in the previous group. At the age of 7–10 years it is during the first ACTH‐day 10.7 mg and during the second ACTH‐day 12.7 mg and in the 11–15 year old children 14.5 mg and 13.4 mg respectively. Per kilogram of body weight the basal excretion has been higher in children than in adults.
The Effect of Intramuscular Iron‐dextran Complex1 on Iron‐deficiency Anaemia in Otherwise Ill Infants and Pre‐school Children
Authors: LANZKOWSKY PHILIP 
Published: January 2008

Summary1. One hundred and twenty‐five ill infants and children who were found to have iron‐deficiency anaemia were treated with intramuscular iron‐dextran complex with doses varying from 100 to 400 mg, concurrent with treatment for the presenting illness.2. The mean haemoglobin levels before treatment ranged from 8.91 g% to 9.61 g% in the various age groups; at 3 weeks after the injection of iron the mean haemoglobin levels were found to range between 10.12 g% and 10.80 g% and at 6 weeks after injection the mean haemoglobin levels had risen further to range between 10.75 g% and 12.0 g%. There was thus an approximate general rise of 2 g% of haemoglobin in 6 weeks. Clinically the beneficial effects were quite striking, and occurred often within days.3. The results of this investigation indicate that intramuscular iron‐dextran complex can significantly raise the haemoglobin level in infants and children who have iron‐deficiency anaemia with a variety of associated illnesses, of all degrees of severity, and of largely undetermined duration. In addition, iron‐dextran complex was found to be safe and easy to administer.4. The factors influencing rate of recovery from iron‐deficiency anaemia after intramuscular iron‐dextran complex, the theoretical dangers of iron overload and the possible production of sarcomata in iron‐injected tissue are discussed.
Sensitivity of Listeria Monocytogenes in vitro to Different Antibiotics and Chemotherapeutics
Authors: NYSTRÖM K. G. , KARLSSON K.‐A. 
Published: January 2008

SummaryThe sensitivity of 14 antibiotics and chemotherapeutics to 86 strains of Listeria monocytogenes isolated from 15 animal species was studied by means of an agar diffusion technique. The tetracyclines (chlortetracycline, oxytetracycline, tetracycline), erythromycin and streptomycin proved to be clearly superior to other antibiotics tested in vitro.No difference in resistance was found referable to the species of animal from which the strains emanated.
Bone Marrow Aplasia in Childhood Leukaemia
Authors: GLÜCK ERNEST , LAMVIK JON 
Published: January 2008

SummarySix of 21 children with blast cell leultaemia were found at post‐mortem to have a hypoplastic or aplastic bone marrow. Leukaemic infiltrations were found in the organs of all the cases with a hyperplastic marrow, but were present in only one of the cases in the aplastic group and are limited to the meninges. The cause of aplasia of the bone marrow in leukaemis is discussed, particularly with regard to the possible influence of the folic acid antagonists. In two of the cases the bone marrow biopsies were indicative of an aplastic course from the start. The treatment in these cases seems to have reduced the activity of the bone marrow still further. In one case the aplasia developed during prolonged treatment with folic acid antagonists; a causal relationship is, however, uncertain. In the remaining three cases there was a haematological response after treatment with folic acid antagonists. At autopsy changes that could have been due to lack of folic acid were found in the organs.
Chromosomal Abnormality in a Mongolism‐Like Syndrome1
Authors: BÖÖK J. A. , GUSTAVSON K.‐H. , SANTESSON BERTA 
Published: January 2008

SummaryThe cytogenetical and clinical observations of a 4 year old girl with a mongolism‐like syndrome are reported. The patient showed a moderate mental and physical retardation. Some signs and symptoms considered characteristic of mongolism were present. Others, such as the dermal patterns of hands and feet, rather contradict this diagnosis. In addition the patient had a bilateral dislocation of the hips and unspecific signs of retinal degeneration. There were no signs of abnormal sexual development.Chromosome studies based on cell cultures derived from bone marrow and skin biopsies revealed a chromosome number of 46 and a consistent karyotype pattern which was interpreted as a combination of trisomy for chromosome no. 21 and mono‐somy for no. 16, or alternatively as a translocation between the short arms of 16/21. Typical sex chromatin was present in 50–60% of the interphase nuclei. Both parents had apparently normal karyotypes and were free from signs or symptoms of significant disease.This patient represents a new genetical disease entity and clinically a variant of the common trisomic type of mongolism.
Serial Blood‐Gas Tensions and Acid‐Base Balance during the First Hour of Life in Human Infants1
Authors: OLIVER T. K. , DEMIS J. A. , BATES G. D. 
Published: January 2008

Summary1. Serial determinations of oxygen and carbon dioxide tension, pH, CO2 content, sodium, potassium, chloride, magnesium, total protein and hematocrit beginning within 5 minutes of birth and continuing through the first hour have been performed in newborn infants.2. The data support the concept that the delivery process is invariably asphyxiating whether delivery is vaginal or by cesarian section. Furthermore, the major recovery occurs within 10 minutes of delivery in healthy infants.3. Arterial oxygen tension was reduced throughout the entire period. Even though the mean arterial oxyhemoglobin satura tion was within normal limits at one hour of age the mean oxygen tension remained low. The interpretation of these findings is discussed.4. The administration of high oxygen concentration to the mothers for periods up to 30 minutes failed to effect the infants' PaO2.5. Evidence is presented for a right to left shunt through the ductus arteriosus when the newborn is quiet as well as crying.6. Serum potassium concentration was found to be considerably elevated in all infants. The mechanisms for this are discussed.7. Differences in acid‐base balance, serum protein concentration and packed cell volume between infants delivered vaginally and by cesarian section were noted. The explanation of these differences is not known.
Clinodactyly and Brachymesophalangia of the Fifth Finger
Authors: ROCHE A. F. 
Published: January 2008

Summary1. Serial radiographs of the hands of 192 mongoloid and 120 normal children extending over four years have been used to investigate the frequency of clinodactyly and brachymesophalangia in the fifth finger and their changes during growth.2. The incidence of clinodactyly in the mongoloid children was similar to that recorded in the literature but the incidence in the normal children was higher than that recorded previously. Clinodactyly with a middle phalanx of the usual length occurred with almost equal frequency in both mongoloid and normal children. There was a marked difference between the two groups of children in the incidence of clinodactyly associated with brachymesophalangia.3. It is suggested that brachymesophalangia is a more important physical sign of mongolism than clinodactyly. Considering children under the age of 8 years, it was present in 25.0% of the mongoloid group and 3.3% of the normal group and was almost always associated with clinodactyly.4. The incidence of clinodactyly did not vary with age but brachymesophalangis was slightly less common among older mongoloids.
Leydig Cell Tumour of the Testis in a 61/2 Year Old Boy
Authors: MOE PETER JOHAN , IVERSEN OLAV HILMAR 
Published: January 2008

SummaryA case of Leydig cell tumour in a 61/2‐year‐old boy is presented. The need for more elaborate methods for the biochemi‐cal separation of Leydig cell tumour from aberrant adreno‐cortical tissue is stressed. Normal urinary output of Pregnanetriol and a lack of increase of the 17‐beta‐ketosteroids in the urine in a patient with a tumour in one of the testes serve to exclude the possibility of an adreno‐cortical disorder.
Gamma Globulin against Rubella in Pregnancy: II. Manifest Maternal Rubella in Early Pregnancy Treated with Convalescent Gamma Globulin: a Follow‐Up Study
Authors: LUNDSTRÖM ROLF , THORÉN CLAES , BLOMQUIST BERNT 
Published: January 2008

SummaryRubella convalescent gamma globulin was given to 28 women with rubella in early pregnancy. Of those treated in the first trimester, pregnancy terminated in foetal death in 32% and 11 of 21 offspring survived. At the age of 34 years, four of the 21 survivors showed abnormalities belonging to the rubella syndrome. Administration of antibodies to women with manifest rubella in early pregnancy did not succeed in preventing foetal damage.
Immune Electrophoretic Studies of Bovine Milk and Milk Products
Authors: HANSON LARS Å. , MÅNSSON I. 
Published: January 2008

SummaryWith immune electrophoretic analysis a descriptive and illustrative picture is obtained of the changes of the milk proteins due to heat. It is apparent that casein resists a temperature of 120°C and that a‐lactalbumin and β‐lacto‐globulin are still antigenic after heating to 100°C for at least 15 minutes, whereas the major immune globulin component as well as a few other proteins are destroyed after heating to 70–80°C for 15 minutes (Tables 1 and 2). The investigation concerns colostrum, mature milk, milk pasteurized by various methods, dried milk, some commercial baby food products and a sample of a milk product advertized as non‐allergenic. The possible application of the reported results to the study of cow milk allergies is discussed.
EEG studies on cases of juvenile diabetes mellitus of long duration
Authors: HERRLIN KARL‐MAGNUS , KARLSSON BENOT , STERKY GÖRAN 
Published: January 2008

SummaryEEG studies on 80 patients 16–38 years of age with juvenile diabetes of more than 15 years duration showed pathological EEGs in 31 per cent, borderline findings in 29 per cent and normal EEGs in 40 per cent of the cases. Pathological EEGs were more common in women than in men. No correlation was found between abnormal EEG findings and other factors such as age at onset, age at the time of study, duration of diabetes, blood sugar level at EEG examination, serum lipid values, degree of diabetic control or appearance of angiopathy. The results of the investigation are in agreement with the hypothesis that EEG abnormality in diabetic patients might be due to constitutional factors.
Dental Development in Children Following Maternal Rubella
Authors: LUNDSTRÖM ROLF , LYSELL LENNART , BERGHAGEN NILS 
Published: January 2008

SummaryIn a country‐wide prospective study of children aged one to three years with histories of maternal rubella born 1951‐52 it was found that 550 children of women with rubella in the first four months of pregnancy had an average of 0.6 teeth less than 429 children with maternal rubella in the fifth and following months and 639 matched controls. The difference was more marked in the children aged approx. 15 months and independent of birth weight, height at birth and size of head circumference at examination. No significant differences were stated in 88 children, belonging to the above‐mentioned series and examined at nearly 5 years of age, regarding the eruption of the first deciduous tooth, incidence of caries, malocclusion, and the gingival. Hypoplasia of enamel or aplasia of teeth wag not found, neither among the rubella children nor the controls.
Penicillin Versus Tetracycline in the Treatment of Childhood Osteomyelitis
Authors: CULLEN C. H. , HARGADON E. J. 
Published: January 2008

SummaryFifty‐eight children with acute haema‐togenous osteomyelitis have been studied. The incidence of infection by penicillin‐resistant organisms was found to be 54.5 % in 33 cases in which an organism was recovered. Tetracycline has been found to be more effective than penicillin in the primary treatment of this condition.
Development of Paraplegia after Breech Presentation
Authors: MELCHIOR J. C. , TYGSTRUP I. 
Published: January 2008

SUMMARYA case history of a boy born in breech presentation is reported together with the autopsy findings. In this case parturition had been uncomplicated. Throughout his seven months of life the boy had been marked by hypotonia of the lower extremities and of respiratory insufficiency. At autopsy a closed, almost transversal lesion of the cervical spinal cord was demonstrated, including progressive, degenerative processes and minor cortical injuries, all of which have probably developed simultaneously. The great value of a pathological‐anatomical examination of the spinal cord is emphasized.
Polymyositis in Childhood A Case Report
Authors: KRYGER JØRGEN , ROSSEL IB 
Published: January 2008

SUMMARYA case of polymyositis in a 7‐year‐old girl, verified by electromyography and biopsy, is described. The difference between dermatomyositis and polymyositis is discussed. According to the literature, polymyositis appears to have a better prognosis. In the case reported, steroids were beneficial. This treatment is discussed