bluuebunny/crossref_metadata_2025_split huggingface dataset:
A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer’s disease
Authors: Tsartsalis Stergios , Sleven Hannah , Fancy Nurun , Wessely Frank , Smith Amy M. , Willumsen Nanet , Cheung To Ka Dorcas , Rokicki Michal J. , Chau Vicky , Ifie Eseoghene , Khozoie Combiz , Ansorge Olaf , Yang Xin , Jenkyns Marion H. , Davey Karen , McGarry Aisling , Muirhead Robert C. J. , Debette Stephanie , Jackson Johanna S. , Montagne Axel , Owen David R. , Miners J. Scott , Love Seth , Webber Caleb , Cader M. Zameel , Matthews Paul M. 
Published: March 2024

AbstractBrain perfusion and blood-brain barrier (BBB) integrity are reduced early in Alzheimer’s disease (AD). We performed single nucleus RNA sequencing of vascular cells isolated from AD and non-diseased control brains to characterise pathological transcriptional signatures responsible for this. We show that endothelial cells (EC) are enriched for expression of genes associated with susceptibility to AD. Increased β-amyloid is associated with BBB impairment and a dysfunctional angiogenic response related to a failure of increased pro-angiogenic HIF1A to increased VEGFA signalling to EC. This is associated with vascular inflammatory activation, EC senescence and apoptosis. Our genomic dissection of vascular cell risk gene enrichment provides evidence for a role of EC pathology in AD and suggests that reducing vascular inflammatory activation and restoring effective angiogenesis could reduce vascular dysfunction contributing to the genesis or progression of early AD.
Vortex-based soft magnetic composite with ultrastable permeability up to gigahertz frequencies
Authors: Bai Guohua , Sun Jiayi , Zhang Zhenhua , Liu Xiaolian , Bandaru Sateesh , Liu Weiwei , Li Zhong , Li Hongxia , Wang Ningning , Zhang Xuefeng 
Published: March 2024

AbstractSoft magnetic materials with stable permeability up to hundreds of megahertz (MHz) are urgently needed for integrated transformers and inductors, which are crucial in the more-than-Moore era. However, traditional frequency-stable soft magnetic ferrites suffer from low saturation magnetization and temperature instability, making them unsuitable for integrated circuits. Herein, we fabricate a frequency-stable soft magnetic composite featuring a magnetic vortex structure via cold-sintering, where ultrafine FeSiAl particles are magnetically isolated and covalently bonded by Al2SiO5/SiO2/Fe2(MoO4)3multilayered heterostructure. This construction results in an ultrastable permeability of 13 up to 1 gigahertz (GHz), relatively large saturation magnetization of 105 Am2/kg and low coercivity of 48 A/m, which we ascribe to the elimination of domain walls associated with almost uniform single-vortex structures, as observed by Lorentz transmission electron microscopy and reconstructed by micromagnetic simulation. Moreover, the ultimate compressive strength has been simultaneously increased up to 337.1 MPa attributed to the epitaxially grown interfaces between particles. This study deepens our understanding on the characteristics of magnetic vortices and provides alternative concept for designing integrated magnetic devices.
Electronic structure modulation of iron sites with fluorine coordination enables ultra-effective H2O2 activation
Authors: Yu Deyou , Xu Licong , Fu Kaixing , Liu Xia , Wang Shanli , Wu Minghua , Lu Wangyang , Lv Chunyu , Luo Jinming 
Published: March 2024

AbstractElectronic structure modulation of active sites is critical important in Fenton catalysis as it offers a promising strategy for boosting H2O2 activation. However, efficient generation of hydroxyl radicals (•OH) is often limited to the unoptimized coordination environment of active sites. Herein, we report the rational design and synthesis of iron oxyfluoride (FeOF), whose iron sites strongly coordinate with the most electronegative fluorine atoms in a characteristic moiety of F-(Fe(III)O3)-F, for effective H2O2 activation with potent •OH generation. Results demonstrate that the fluorine coordination plays a pivotal role in lowering the local electron density and optimizing the electronic structures of iron sites, thus facilitating the rate-limiting H2O2 adsorption and subsequent peroxyl bond cleavage reactions. Consequently, FeOF exhibits a significant and pH-adaptive •OH yield (~450 µM) with high selectivity, which is 1 ~ 3 orders of magnitude higher than the state-of-the-art iron-based catalysts, leading to excellent degradation activities against various organic pollutants at neutral condition. This work provides fundamental insights into the function of fluorine coordination in boosting Fenton catalysis at atomic level, which may inspire the design of efficient active sites for sustainable environmental remediation.
Daily artificial gravity partially mitigates vestibular processing changes associated with head-down tilt bedrest
Authors: Tays G. D. , Hupfeld K. E. , McGregor H. R. , Beltran N. E. , De Dios Y. E. , Mulder E. , Bloomberg J. J. , Mulavara A. P. , Wood S. J. , Seidler R. D. 
Published: March 2024

AbstractMicrogravity alters vestibular signaling and reduces body loading, driving sensory reweighting. The unloading effects can be modelled using head-down tilt bedrest (HDT). Artificial gravity (AG) has been hypothesized to serve as an integrated countermeasure for the declines associated with HDT and spaceflight. Here, we examined the efficacy of 30 min of daily AG to counteract brain and behavior changes from 60 days of HDT. Two groups received 30 min of AG delivered via short-arm centrifuge daily (n = 8 per condition), either in one continuous bout, or in 6 bouts of 5 min. To improve statistical power, we combined these groups (AG; n = 16). Another group served as controls in HDT with no AG (CTRL; n = 8). We examined how HDT and AG affect vestibular processing by collecting fMRI scans during vestibular stimulation. We collected these data prior to, during, and post-HDT. We assessed brain activation initially in 12 regions of interest (ROIs) and then conducted an exploratory whole brain analysis. The AG group showed no changes in activation during vestibular stimulation in a cerebellar ROI, whereas the CTRL group showed decreased activation specific to HDT. Those that received AG and showed little pre- to post-HDT changes in left vestibular cortex activation had better post-HDT balance performance. Whole brain analyses identified increased pre- to during-HDT activation in CTRLs in the right precentral gyrus and right inferior frontal gyrus, whereas AG maintained pre-HDT activation levels. These results indicate that AG could mitigate activation changes in vestibular processing that is associated with better balance performance.
The effects of long-term exposure to microgravity and body orientation relative to gravity on perceived traveled distance
Authors: Jörges Björn , Bury Nils , McManus Meaghan , Bansal Ambika , Allison Robert S. , Jenkin Michael , Harris Laurence R. 
Published: March 2024

AbstractSelf-motion perception is a multi-sensory process that involves visual, vestibular, and other cues. When perception of self-motion is induced using only visual motion, vestibular cues indicate that the body remains stationary, which may bias an observer’s perception. When lowering the precision of the vestibular cue by for example, lying down or by adapting to microgravity, these biases may decrease, accompanied by a decrease in precision. To test this hypothesis, we used a move-to-target task in virtual reality. Astronauts and Earth-based controls were shown a target at a range of simulated distances. After the target disappeared, forward self-motion was induced by optic flow. Participants indicated when they thought they had arrived at the target’s previously seen location. Astronauts completed the task on Earth (supine and sitting upright) prior to space travel, early and late in space, and early and late after landing. Controls completed the experiment on Earth using a similar regime with a supine posture used to simulate being in space. While variability was similar across all conditions, the supine posture led to significantly higher gains (target distance/perceived travel distance) than the sitting posture for the astronauts pre-flight and early post-flight but not late post-flight. No difference was detected between the astronauts’ performance on Earth and onboard the ISS, indicating that judgments of traveled distance were largely unaffected by long-term exposure to microgravity. Overall, this constitutes mixed evidence as to whether non-visual cues to travel distance are integrated with relevant visual cues when self-motion is simulated using optic flow alone.
Intergranular corrosion of Ni-30Cr in high-temperature hydrogenated water after removing surface passivating film
Authors: Kruska K. , Olszta M. J. , Wang J. , Schreiber D. K. 
Published: March 2024

AbstractHigh-resolution transmission electron microscopy and atom probe tomography are used to characterize the initial passivation and subsequent intergranular corrosion of degraded grain boundaries in a model Ni-30Cr alloy exposed to 360 °C hydrogenated water. Upon initial exposure for 1000 h, the alloy surface directly above the grain boundary forms a thin passivating film of Cr2O3, protecting the underlying grain boundary from intergranular corrosion. However, the metal grain boundary experiences severe Cr depletion and grain boundary migration during this initial exposure. To understand how Cr depletion affects further corrosion, the local protective film was sputtered away using a glancing angle focused ion beam. Upon further exposure, the surface fails to repassivate, and intergranular corrosion is observed through the Cr-depleted region. Through this combination of high-resolution microscopy and localized passive film removal, we show that, although high-Cr alloys are resistant to intergranular attack and stress corrosion cracking, degradation-induced changes in the underlying metal at grain boundaries make the material more susceptible once the initial passive film is breached.
Possible role of lncRNAs in amelioration of Parkinson’s disease symptoms by transplantation of dopaminergic cells
Authors: Amini A. , Esmaeili F. , Golpich M. 
Published: March 2024

AbstractLong non-coding RNAs (lncRNAs) are biomarkers for diagnosis and treatment of Parkinson’s disease (PD). Since dopaminergic cell transplantation is a clinical method to treat PD, this study investigated the effects of dopaminergic cell therapy on the expression of some lncRNAs and genes related to PD. In this study, Twenty-eight rats were randomly assigned to four experimental groups. The control group (Sal group) received saline injections. The Par group was a PD rat model with 6-hydroxydopamine (6-OHDA) injection in right striatum (ST). PD animals were transplanted by undifferentiated P19 stem cells (Par-E group), and P19-derived dopaminergic cells (Par-N group). Cell transplant effects were evaluated using behavioral tests (cylinder, open field, and rotarod tests), and histological methods (H&E and Nissl staining, and immunohistochemistry). Moreover, the expression of lncRNAs MALAT1, MEG3, and SNHG1, alongside specific neuronal (synaptophysin) and dopaminergic (tyrosine hydroxylase) markers was evaluated by qRT-PCR. Behavioral and histopathological examinations revealed that cell transplantation partially compensated dopaminergic cell degeneration in ST and substantia nigra (SN) of PD rats. The expression of MALAT1, SNHG1, and MEG3 was decreased in the ST of the Par group, while MEG3 and SNHG1 gene expression was increased in PBMC relative to the Sal group. In PBMC of the Par-N group, all three lncRNAs showed a reduction in their expression. Conversely, MALAT1 and SNHG1 expression was increased in ST tissue, while MEG3 gene expression was decreased compared to the Sal group. In conclusion, dopaminergic cell transplantation could change the lncRNAs expression. Furthermore, it partially improves symptoms in PD rats.
Adsorption and DFT investigations of Cr(VI) removal using nanocrystals decorated with graphene oxide
Authors: Singh Simranjeet , Anil Amith G. , Uppara Basavaraju , Behera Sushant K. , Nath Bidisha , N Pavithra , Bhati Shipra , Singh Joginder , Khan Nadeem A. , Ramamurthy Praveen C. 
Published: March 2024

AbstractIn this research, a solvothermal approach is introduced to synthesize a metal-organic frameworks (MOFs) nanocomposite (GO/UiO-66-NDC) for the removal of Cr(VI) from water. A comprehensive analysis was performed to understand the physical, chemical, and structural properties of the MOF nanocomposite. The adsorption behavior of Cr(VI) was investigated by changing various parameters, such as pH, dosage, and concentration, to determine isotherms, thermodynamics, and kinetics. The results showed that the nanocomposite had a high tolerance to pH and thermal stability, with a high adsorption capacity of 157.23 mg g−1 for Cr(VI) at pH 3 due to the presence of zirconium oxide clusters. The density functional theory simulations showed that the nanocomposite had ten times more dynamic delocalized surface states, which enhanced the adsorption capacity and agreed with the experimental results. Furthermore, the nanocomposite exhibited better regeneration performance compared to previously reported materials, making it a promising super-adsorbent for removing Cr(VI) from water.
Peptidoglycan synthesis drives a single population of septal cell wall synthases during division in Bacillus subtilis
Authors: Whitley Kevin D. , Grimshaw James , Roberts David M. , Karinou Eleni , Stansfeld Phillip J. , Holden Séamus 
Published: March 2024

AbstractBacterial cell division requires septal peptidoglycan (sPG) synthesis by the divisome complex. Treadmilling of the essential tubulin homologue FtsZ has been implicated in septal constriction, though its precise role remains unclear. Here we used live-cell single-molecule imaging of the divisome transpeptidase PBP2B to investigate sPG synthesis dynamics in Bacillus subtilis. In contrast to previous models, we observed a single population of processively moving PBP2B molecules whose motion is driven by peptidoglycan synthesis and is not associated with FtsZ treadmilling. However, despite the asynchronous motions of PBP2B and FtsZ, a partial dependence of PBP2B processivity on FtsZ treadmilling was observed. Additionally, through single-molecule counting experiments we provide evidence that the divisome synthesis complex is multimeric. Our results support a model for B. subtilis division where a multimeric synthesis complex follows a single track dependent on sPG synthesis whose activity and dynamics are asynchronous with FtsZ treadmilling.
Penning micro-trap for quantum computing
Authors: Jain Shreyans , Sägesser Tobias , Hrmo Pavel , Torkzaban Celeste , Stadler Martin , Oswald Robin , Axline Chris , Bautista-Salvador Amado , Ospelkaus Christian , Kienzler Daniel , Home Jonathan 
Published: March 2024

AbstractTrapped ions in radio-frequency traps are among the leading approaches for realizing quantum computers, because of high-fidelity quantum gates and long coherence times1–3. However, the use of radio-frequencies presents several challenges to scaling, including requiring compatibility of chips with high voltages4, managing power dissipation5 and restricting transport and placement of ions6. Here we realize a micro-fabricated Penning ion trap that removes these restrictions by replacing the radio-frequency field with a 3 T magnetic field. We demonstrate full quantum control of an ion in this setting, as well as the ability to transport the ion arbitrarily in the trapping plane above the chip. This unique feature of the Penning micro-trap approach opens up a modification of the quantum charge-coupled device architecture with improved connectivity and flexibility, facilitating the realization of large-scale trapped-ion quantum computing, quantum simulation and quantum sensing.
De novo-designed transmembrane proteins bind and regulate a cytokine receptor
Authors: Mravic Marco , He Li , Kratochvil Huong T. , Hu Hailin , Nick Sarah E. , Bai Weiya , Edwards Anne , Jo Hyunil , Wu Yibing , DiMaio Daniel , DeGrado William F. 
Published: March 2024

AbstractTransmembrane (TM) domains as simple as a single span can perform complex biological functions using entirely lipid-embedded chemical features. Computational design has the potential to generate custom tool molecules directly targeting membrane proteins at their functional TM regions. Thus far, designed TM domain-targeting agents have been limited to mimicking the binding modes and motifs of natural TM interaction partners. Here, we demonstrate the design of de novo TM proteins targeting the erythropoietin receptor (EpoR) TM domain in a custom binding topology competitive with receptor homodimerization. The TM proteins expressed in mammalian cells complex with EpoR and inhibit erythropoietin-induced cell proliferation. In vitro, the synthetic TM domain complex outcompetes EpoR homodimerization. Structural characterization reveals that the complex involves the intended amino acids and agrees with our designed molecular model of antiparallel TM helices at 1:1 stoichiometry. Thus, membrane protein TM regions can now be targeted in custom-designed topologies.
EUPRO - A reference database on project-based R&D collaboration networks
Authors: Scherngell Thomas , Barber Michael , Zahradnik Georg , Wolfmayr Anna , Bilalli Shkodra Xheneta 
Published: March 2024

AbstractThe EUPRO database enables the analysis of participation patterns of organisations in and across different European R&D funding initiatives and the investigation of resulting collaborative R&D network structures and dynamics. The perimeter of EUPRO is currently more than 600,000 R&D projects funded by European (EU, transnational or national) research funding organisations, comprising systematic information about contents of the R&D projects, their participating organizations (including organisation type and location), and a number of additional characteristics (e.g. underlying policy instrument and programme). This scientific data descriptor serves as illustrative information source for users, both from science as well as from policy. It discusses the conceptual background and derives respective analytical opportunities for different actual, highly relevant debates in innovation studies and related fields. Moreover, the data collection process is described in a compact manner, as well as how the collected data are harmonized and aggregated into a suitable data model for analytical purposes. Finally, we put forward issues of technical validation, data quality and enrichment, and usage notes on how to access EUPRO.
Administrative data ICD-10 diagnostic codes identifies most lab-confirmed SARS-CoV-2 admissions but misses many discharged from the Emergency Department
Authors: Moura Cristiano S. , Morrison Laurie J. , Hohl Corinne M. , Grant Lars , Pilote Louise , Neville Autumn , Hau Jeffrey P. , Bernatsky Sasha ,   and the Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators,   for the Network of Canadian Emergency Researchers,   the Canadian Critical Care Trials Group
Published: March 2024

AbstractWe estimated the operating characteristics of ICD-10 code U07.1, introduced by the World Health Organization in 2020, to identify lab-confirmed SARS-CoV-2. CCEDRRN is a national research registry of adults (March 2020–August 2021) with suspected/confirmed SARS-CoV-2 identified in Canadian emergency departments (EDs) using chart review (symptoms, clinical information, and lab test results including SARS-CoV-2 polymerase chain reaction, PCR results). CCEDRRN data were linked to administrative hospitalization discharge and ED ICD-10 diagnostic codes (accessed centrally via the Canadian Institute for Health Information). We identified ICD-10 diagnostic codes in CCEDRRN participants. We defined lab-confirmed SARS-CoV-2 based on at least one positive PCR in the 0–14 days before the ED presentation and/or during hospitalization (in those admitted from ED). We performed separate analyses for CCEDRRN participants discharged from ED and those hospitalized from the ED. Additional analyses were stratified by province, sex, age, and (for hospitalized patients) timing of the first PCR test. The sensitivity of ICD-10 code U07.1 for a positive SARS-CoV-2 test was 93.6% (95% CI 93.0–94.1%) in those hospitalized from ED and 83.0% (95% CI 82.1–83.9%) in those discharged from the ED. Sensitivity was similar across provinces and demographics, but in each stratified analysis, values were higher in those hospitalized versus those discharged from ED. The ICD-10 diagnostic code for U07.1 within administrative data identified most lab-confirmed SARS-CoV-2 within persons hospitalized from ED, although a significant number of cases discharged from ED were missed. This should be considered when using administrative data for research and public health planning.
Improving our understanding of future tropical cyclone intensities in the Caribbean using a high-resolution regional climate model
Authors: Dullaart Job C. M. , de Vries Hylke , Bloemendaal Nadia , Aerts Jeroen C. J. H. , Muis Sanne 
Published: March 2024

AbstractThe Caribbean region is prone to the strong winds and low air pressures of tropical cyclones and their corresponding storm surge that driving coastal flooding. To protect coastal communities from the impacts of tropical cyclones, it is important to understand how this impact of tropical cyclones might change towards the future. This study applies the storyline approach to show what tropical cyclones Maria (2017) and Dorian (2019) could look like in a 2 °C and 3.4 °C warmer future climate. These two possible future climates are simulated with a high-resolution regional climate model using the pseudo global warming approach. Using the climate response from these simulations we apply a Delta-quantile mapping technique to derive future changes in wind speed and mean sea level pressure. We apply this Delta technique to tropical cyclones Maria and Dorian’s observed wind and pressure fields to force a hydrodynamic model for simulating storm surge levels under historical and future climate conditions. Results show that the maximum storm surge heights of Maria and Dorian could increase by up to 0.31 m and 0.56 m, respectively. These results clearly show that future changes in storm surge heights are not negligible compared to end-of-the-century sea level rise projections, something that is sometimes overlooked in large-scale assessments of future coastal flood risk.