bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Feasibility of Short-Stretch Compression Therapy for Filarial Lymphedema in Sri Lanka
Authors: Hall Jaimee M. , De Silva Nirmitha Lalindi , Ruben Janaka , Thilakarathne Sandani S. , Yahathugoda Thishan Channa , Budge Philip J. 
Published: March 2024

ABSTRACT.
The WHO-recommended essential package of care (EPC) for filarial limb lymphedema consists of daily limb washing, entry lesion management, limb protection, exercises, and elevation. Decongestive therapy (DT) with compression bandaging by trained lymphedema therapists adds additional benefit but is unavailable for most in low- and middle-income countries (LMICs). To determine whether DT using self-adjustable, short-stretch compression garments (SSCG), prefitted using portable, three-dimensional infrared imaging (3DII), would be effective and feasible in LMIC settings, we conducted a pilot 6-week, interventional, single-group, open-label pilot study in Galle, Sri Lanka. Ten participants with Dreyer stage 3 lymphedema used SSCG for 2 weeks after a 4-week lead-in EPC period. Effect of EPC and compression on quality of life was assessed using the 12-item WHO Disability Assessment Schedule 2.0 (WHODAS 2.0). Median participant age was 73 years (range: 32–85 years). Median percent limb volume reduction due to compression was 11.3% (range: 1.1–27.2%). WHODAS 2.0 scores did not change significantly between enrollment and study end. Garment acceptability was high throughout the study. These results provide proof of concept for 3DII-enabled SSCG in LMICs where trained therapists for filarial lymphedema may not be available.
SARS-CoV-2 Seroprevalence and Vaccine Uptake among Pregnant Women at First Antenatal Care Visits in Malawi
Authors: Tenthani Lyson , Seffren Victoria , Kabaghe Alinune Nathanael , Ogollah Francis , Soko Monica , Yadav Ruchi , Kayigamba Felix , Payne Danielle , Wadonda-Kabondo Nellie , Kampira Elizabeth , Volkmann Tyson , Sugandhi Nandita S. , Seydel Karl , Rogier Eric , Thwing Julie I. , Gutman Julie R. 
Published: March 2024

ABSTRACT.
Many SARS-CoV-2 infections are asymptomatic, thus reported cases underestimate actual cases. To improve estimates, we conducted surveillance for SARS-CoV-2 seroprevalence among pregnant women attending their first antenatal care visit (ANC1) from June 2021 through May 2022. We administered a questionnaire to collect demographic, risk factors, and COVID-19 vaccine status information and tested dried blood spots for SARS-CoV-2 antibodies. Although <1% of ANC1 participants reported having had COVID-19, monthly SARS-CoV-2 seroprevalence increased from 15.4% (95% CI: 10.5–21.5) in June 2021 to 65.5% (95% CI: 55.5–73.7) in May 2022. Although COVID-19 vaccination was available in March 2021, uptake remained low, reaching a maximum of 9.5% (95% CI: 5.7–14.8) in May 2022. Results of ANC1 serosurveillance provided prevalence estimates helpful in understanding this population case burden that was available through self-report and national case reports. To improve vaccine uptake, efforts to address fears and misconceptions regarding COVID-19 vaccines are needed.
Case Report: Itraconazole Oral Solution Continuous Therapy for Infantile Tinea Capitis
Authors: Zhou Ya Bin , Chao Jin Jing , Ma Lin , Xiao Yuan Yuan 
Published: March 2024

ABSTRACT.
Tinea capitis is a common fungal infection caused by dermatophytes in children, but it is rare in infants. Although oral itraconazole has been widely used to treat tinea capitis, its use in infants is limited due to its low prevalence in this age group. A previous study reported the effectiveness of itraconazole continuous therapy in treating infantile tinea capitis caused by Microsporum canis. However, this approach has not been extended to tinea capitis caused by other fungi. In this study, we present four cases of infantile tinea capitis treated with continuous itraconazole oral solution therapy (5 mg/kg/day). Two patients were infected with M. canis, one patient with Nannizzia gypsea, and another with Trichophyton tonsurans. This study assesses the efficacy and safety of itraconazole oral solution continuous therapy, expanding our understanding by demonstrating its effectiveness for infantile tinea capitis caused by T. tonsurans and N. gypsea.
Celtis australis Exhibits Cytotoxic Effects by Inducing DNA Damage in Human Ovarian Cancer Cells
Authors: Fidan Gülsüm Nur , Günay Sevilay , Erden Yavuz 
Published: March 2024

Native to the Mediterranean and southwest Asia, Celtis australis is used in folk medicine to treatment of many diseases such as peptic ulcer, diarrhea, dysentery, pain, and colic. However, there are very few studies on the effects of this species on cancer. We report for the first time the cytotoxic and genotoxic properties of C. australis on the human ovarian cancer cell line A2780.
In the study, C. australis extract prepared in ethanol/phosphate buffer was applied to A2780 cells. The change in viability level in A2780 cells after treatment was determined by MTT assay and DNA damage was determined by single-cell gel electrophoresis (Comet) analysis.
Our results showed that plant extract application at doses above 200 µg/ml significantly decreased A2780 cell viability (p
Archives Repositioning: Unveiled the Fact, Archives is Information
Authors: Wulandari Sari Agustin 
Published: March 2024

This work starts with a very simple question, where do archives position in DIKW pyramid? To know the answer, researcher using an SLR method, with kitchenhamm approach. Other thing, researcher reffer to Data, Information, Knowledge, Wisdom hierarchy or known as piramid of knowledge, the purpose of doing so is to avoid terminology bias.
From that method, researcher found 16 literatures as reference for extraction and sintetycally analized. Boolean string use also being done for simplifying literature filtering from 5 availiable digital database, which is science direct, ACM, Digutal Library, Jstor, Springer and Portal Garuda. The result of this research is only 1 from 16 literatures which consider archives as data, while 15 other literatues consider archives as information in formation knowledge pyramid and decisions making process.
KEWENANGAN PENYIDIKAN PADA TINDAK PIDANA KORUPSI DALAM SISTEM PERADILAN PIDANA
Authors: Muhammad Romadhan  , Muhammad Nugraha  , Aldy Sopandy  , Zain Agiel Abdullah  , Andreas Jona Situmorang  , Kesuma Derry Angling 
Published: March 2024

AbstrakPada hakekatnya hukum diciptakan di dalam pergaulan hidup bermasyarakat, baik dalam lingkungan kecil maupun dalam lingkungan yang lebih besar, agar di dalamnya terdapat keserasian, ketertiban, kepastian hukum dan lain sebagainya. Agar semua orang dapat bertingkah laku yang benar, harus ada ketentuan yang dapat dijadikan tolok ukur. Apabila terjadi perbuatan yang melanggar hukum atau menyimpang dari keserasian, ketertiban dan kedamaian dalam pergaulan hidup maka akan ada hukuman atau pidana berupa sanksi hukum bagi pelakunya. Sanksi hukum ini akan menimbulkan penderitaan baik secara fisik maupun secara mental bagi semua orang yang melakukan kejahatan, sehingga ia jera atau kapok untuk mengulangi kembali perbuatannya. Budaya yang terbentuk di suatu lembaga yang berjalan terus menerus terhadap korupsi dan penyuapan dapat menyebabkan korupsi sebagai hal biasa. Pelaksanaan sistem perdilan pidana, hingga saat ini belum menunjukkan kinerja secara optimal dikarenakan secara struktural tidak bersifat terpadu dalam hal konsep fungsi dan pengawasan dalam manejemen sistem peradilan/penegakan hukum tidak dalam arti luas, lemah dalam penegakan hukum sebab berkedudukan di bawah kekuasaan eksekutif (pemerintah) sehingga dalam hal-hal tertentu pelaksanaan penegakan hukum pidana mendapat pengaruh kekuasaan eksekutif dan tidak menutup kemungkinan pengaruh kekuasaan lainnya, jadi masih belum ada ketegasan mengenai perbedaan antara fungsi eksekutif, yudikatif, dan legislatif.
Kata kunci : Penyidik, Korupsi, Tindak Pidana
AbstractCriminal acts of fraud are currently growing following the times and advances in technology. Legal regulations are made to anticipate this, but the existing regulations do not seem to reduce these crimes but have increased. This study aims to: first, determine law enforcement against criminal acts of fraud based on e-commerce; and second, knowing the inhibiting factors in enforcing criminal law against criminal acts of e-commerce based fraud. The results of the study illustrate that the crime of fraud based on e-commerce is in principle the same as fraud in the conventional way, but the difference lies in the evidence or means of action, namely using electronic systems (computers, internet, telecommunication devices). Therefore law enforcement regarding this crime of fraud should still be accommodated by the Criminal Code through article 378, and to strengthen the legal basis it can also be accommodated through Article 28 paragraph (1) of Law Number 19 of 2016 concerning Information and Electronic Transactions. As a special law (Lex Specialist Derogat Lex Generale), the ITE Law can at least become a guideline and legal basis for members of the public in their activities in cyberspace.
Keywords: Law Enforcement, Transactions, Buying and Selling, Online
BENTUK PERLINDUNGAN HUKUM KEPADA ANAK SEBAGAI KORBAN TINDAK PIDANA KESUSILAAN DALAM HUKUM PIDANA POSITIF SAAT INI
Authors: Farah Andriani  , Msy. Arifah Sumayyah  , Muhammad Ria Revanza  , Fajri Ramadhan  , M. Ivandi Aulia  , Haryadi Tobi 
Published: March 2024

AbstrakMasalah tindak pidana asusila terhadap anak muncul karena pelaksanaan hukum pidana tidak berorientasi pada nilai keadilan, terutama pada perlindungan korban, melainkan pada penerapan pemidanaan terhadap pelaku tindak pidana. Akibatnya, tidak menakut-nakuti orang tentang kejahatan kesusilaan, apalagi tentang pemerkosa dan pelecehan seksual anak. Masalah penelitian ini adalah bagaimana ketentuan perlindungan hukum bagi anak yang menjadi korban tindak pidana asusila menurut hokum pidana positif saat ini. Perlindungan hukum terhadap anak korban tindak pidana kesusilaan dalam hukum pidana positif saat ini terdapat pada Pasal 287, 290, 292, 293, 294 dan 295 KUHP dan Pasal 81 dan82, Undang-Undang. Nomor. 23/ 2002 jo. Undang-Undang. Nomor. 35 Tahun 2014jo Perpu No.1/ 2016 tentang Perubahan kedua atas Undang-Undang Nomor. 23/2002 tentang Perlindungan Anak, dan apabila korban termasuk dalam lingkup rumah tangga, maka berlaku juga ketentuan Pasal 46 dan 47 Undang-Undang Nomor 23 / 2004 tentang Penghapusan KDRT, serta Undang-Unang Nomor 31/2014 tentang Perlindungan Saksi dan Korban. kelemahan yang muncul pada Undang-Undang Nomor 31/2014 adalah belum adanya suatu ketentuan yang mengatur sanksi apabila pelaku tidak memberi restitusi bagi korban.
Kata Kunci : Perlindungan Hukum, Anak, Kejahatan Moral.
SOSIALISASI KEBIJAKAN PELAKU USAHA YANG MEMUAT PERLINDUNGAN HAK KETANAKERJAAN PEREMPUAN TERKAIT DENGAN PELAKSANAAN PENGHORMATAN HAK-HAK PEREMPUAN DI PERUSAHAAN
Authors: Nur Aziza  , Fitri Yani  , Diah Syawitri  , Muhammad Fajar Fadillah  , Riko Anggara Putra  , Riviyusnita Rianda 
Published: March 2024

AbstrakSesuai amanat Undang-Undang, pekerja perempuan tentunya mendapatkan hak yang sama dengan pekerja laki-laki. Berbagai hal harus diketahui tentang upaya pemerintah dalam memberikan perlindungan bagi pekerja perempuan didalam dunia kerja seiring dengan kebutuhan ekonomi dalam suatu masyarakat. sampai saat ini, pemberi kerja dalam pelaksanaan kewajiban perlindungan bagi tenaga kerja perempuan, masih cukup banyak yang belum melaksanakan secara utuh atas perlindungan tersebut yang mencakup ; istirahat haid, istirahat melahirkan, stirahat gugur kandungan, kesempatan menyusui, juga ilarangan imemperkerjakan itenaga ikerja iperempuan hamil pada kondisi berbahaya dan adanya kewajiban yang menentukan bagi tenaga kerja perempuan yang bekerja dimalam hari. kementrian ketenagakerjaan (kemnaker) menghimbau semua pihak agar semakin mengutamakan perlindungan bagi tenaga kerja perempuan. Sehingga mampu memberikan nilai tambah terhadap reputasi prestise, dan nama baik perusahaan, sebagai entitas yang berkomitmen dalam mewujudkan dunia kerja inklusif, dalam penghormatan asas kesetaraan.
Kata Kunci: Ketenagakerjaan, Hak-Hak Perempuan, Pelaku Usaha.
IMPLEMENTASI BATAL DEMI HUKUM DALAM PERJANJIAN KERJA MENURUT UNDANG-UNDANG NOMOR 13 TAHUN 2003 TENTANG KETENAGAKERJAAN
Authors: Julianto  , Muhammad Abdurrahman  , M. Soheh Salahudin W  , Alvin Reynaldo  , Reggy Permana  , Husnaini Husnaini 
Published: March 2024

Abstrak
Hubungan kerja pada dasarnya adalah hubungan antara pekerja/buruh dan pengusaha setelah adanya perjanjian kerja. Perjanjian kerja merupakan awal dimulai suatu hubungan kerja yang dibuat atas pernya taan kesanggupan antara pekerja/buruh dengan pengusaha. Perjanjian kerja dapat dilakukan secara lisan maupun tulisan. bagaimana implementasi makna batal demi hukum dalam perjanjian kerja yang bertentangan dengan Undang-Undang Nomor 13 Tahun 2003 Tentang Ketenagakerjaan. Penelitian yang digunakan adalah penelitian hukum normatif yaitu sebuah metode penelitian hukum yang dilakukan dengan meneliti bahan pustaka atau data sekunder. Sumber data sekunder yaitu berupa dokumen-dokumen tertulis, peraturan perundang-undangan dan litelatur-litelatur yang berkaitan dengan objek penelitian ini. Makna batal demi hukum berarti perjanjian kerja tersebuat seolah-olah tidak pernah ada atau sejak semula secara yuridis tidak pernah ada perjanjian. Namun dalam kenyataan yang sering terjadi walaupun pekerjaaan tersebut batal demi hukum ada tetapi pekerja atau buruh masih tetap diperkerjakan hingga saatnya terjadilah pemutusan hubungan kerja.
Kata Kunci: Batal Demi Hukum, Perjanjian, Kerja
PENGARUH PUTUSAN PAILIT TERHADAP TANGGUNG JAWAB ORGAN SUATU PERUSAHAAN
Authors: Layang Sardana  , Ermini  , Suryati  
Published: March 2024

Abstrak
Sebuah kepailitan pada sebuah perusahaan dapat mengakibatkan hubungan kerja akan berakhir atau diakhiri oleh seseorang. Berdasarkan hal tersebut sering terjadi perselisihan antara pengusaha dengan pekerja. Perselisihan antara para pihak biasanya disebabkan adanya perasaan kurang puas. Pengusaha memberikan kebijakan yang menurutnya sudah baik, namun pekerja yang bersangkutan mempunyai pertimbangan dan pandangan sendiri sehingga tidak puas dengan kebijakan yang diberikan. Adapun tujuan dari penelitian ini adalah untuk mengetahui pengaruh putusan pailit terhadap tanggungjawab organ suatu perusahaan. Jenis penelitian hukum yang digunakan dalam penelitian adalah penelitian yuridis normative. Hasil penelitianini bahwa efek dari pernyataan pailit berdampak bagi Direksi dan Komisaris yang dijelaskan dalam Pasal 93 dan Pasal 110 UU No. 40 Tahun 2007 tentang Perseroan Terbatas yang menyatakan direksi dan komisaris tidak dapat diangkat kembali dalam jabatannya tersebut jika dalam waktu 5 tahun sebelum pengangkatannya pernah dinyatakan pailit. Hal ini dipertegas kembali dalam Pasal 95 dan Pasal 112 UU No. 40 Tahun 2007 tentang Perseroan Terbatas yang menyatakan pengangkatan yang tidak memenuhi persyaratan tersebut batal demi hukum sejak saat anggota Direksi atau Dewan Komisaris mengetahui persyaratan tersebut.
Kata Kunci: Putusan Pailit, Tanggung Jawab Organ Perusahaan

Abstract
A bankruptcy to a company may result in a working relationship being ended or terminated by a person. Based on this there are often disputes between employers and workers. Disputes between the parties are usually caused by feelings of dissatisfaction. Employers provide policies that they think are good, but the workers in question have their own considerations and views so are not satisfied with the policy given. The purpose of this research is to find out the effect of bankruptcy rulings on a company's organ responsibilities. The type of legal research used in research is normative juridical research. The result of this research is that the effect of the bankruptcy statement has an impact on the Board of Directors and Commissioners described in Article 93 and Article 110 of Law No. 40 of 2007 on the Limited Liability Company which states that the board of directors and commissioners cannot be reappointed in such positions if within 5 years before his appointment has been declared bankrupt. This is reaffirmed in Article 95 and Article 112 of Law No. 40 of 2007 on Limited Liability Companies stating that appointments that do not meet the requirements are null and void from the moment a member of the Board of Directors or Board of Commissioners is aware of the requirement.
Keywords : Bankruptcy Verdict, Corporate Organ Responsibility
PENYELESAIAN SENGKETA KONSUMEN DI INDONESIA
Authors: Nur Amin Muhammad , Liza Deshaini  
Published: March 2024

Abstrak
Penyelesaian sengketa konsumen di Peradilan Umum adalah dengan pengajuan gugatan dan pemeriksaan pembuktian di pengadilan sedangkan penyelesaian sengketa konsumen di Luar Pengadilan adalahdengan penyelesaian penggantian kerugian seketika (secara langsung) dengan jalan damaidan tuntutan penggantian kerugian melalui Badan Penyelesaian Sengketa Konsumen (BPSK).
Kata Kunci :Penyelesaian, Sengketa, Konsumen

Abstract
Settlement of consumer disputes in the General Courts is by filing lawsuits and examining evidence in court while settlement of consumer disputes outside the Court is by settlement of immediate (direct) compensation by peaceful means and claims for compensation through the Consumer Dispute Settlement Agency (BPSK).
Keywords: Settlement, Dispute, Consumers
Pengaruh Remunerasi, Lingkungan Kerja dan Kompetensi Terhadap Kepuasan Kerja
Authors: Aysyah Rengganis  , Ade Yovi Novalesi  , Ishak Hanawi  , Muhammad Nasir  , Hasrita Lubis  , Ismail Nasution  
Published: March 2024

This research aims to find out the influence jointly or partially between remuneration, work environment and competence to the job satisfaction of the Workers at the Sekolah Menengah Kejuruan Swasta Siti Banun. This research uses descriptive qualitative method using primary and secondary data. The population is the workers of the company. Fifty five become the sample of this research. Data analysis technique used is linear regression which shows that from the three independent variables applied to the regression model (remuneration, work environment and competence). Remuneration is significant for 0,003 which can be concluded that remuneration affects job satisfaction (hypothesis 1 accepted). Work environment has significant value 0,001 which can be concluded that quality of work environment (hypothesis 2 accepted). Competence variable has significant value 0,001 which means that competence influences job satisfaction (hypothesis 3 accepted). Research results show that remuneration, work environment and competence all positively influence the job satisfaction of the workers. It can be proven using the result of regression statistic test with probability value 0,000 obtained which is lower than α (α=0,05). So, it can be said that remuneration, work environment and competence influence positively the job satisfaction of the workers. Thus, hypothesis 4 accepted
Analisis Penerapan Metode Simpleks Linier Programming Pada Home Industry Martabak
Authors: Ayu Azizah  , Rani  , Khoirul Ulum  , Faizal Roni  , Eni Reptiningsih  
Published: March 2024

Linear programming is a planning technique that uses mathematical models with the aim of finding the best product combinations in preparing an allocation of limited resources in order to achieve goals that are used optimally Sofjan Assauri (Hermawan, 2016). The simplex method is an approach in solving linear programming problems that have two or more decision variables where determining the optimal combination is done through repeated iterations of the simplex table until the optimum value is found in the optimization problem which includes maximizing profits or minimizing costs. The martabak home industry is one of the businesses operating in the culinary sector. One of the problems faced by the Martabak 88 home industry is determining the optimum production amount so as to obtain maximum profits. Therefore, a method is needed to determine the right combination of products made and the combination of products produced. The simplex method is the method used in this research to estimate the maximum profit obtained from sweet martabak and egg martabak.
Effectiveness of Digital Detox Interventions in Mitigating the Negative Effects of Social Media among Adolescents and Young Adults in Malawi
Authors: Mhone Charity 
Published: March 2024

Purpose: The aim of the study was to investigate the effectiveness of digital detox interventions in mitigating the negative effects of social media among adolescents and young adults.
Methodology: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries.
Findings: Research on digital detox interventions for Malawian youth is limited, but broader studies suggest effectiveness. These interventions reduce social media use, easing loneliness and anxiety while improving sleep. They also encourage offline activities, fostering social engagement and personal growth. Moreover, digital detox programs promote digital literacy, empowering critical social media navigation. Yet, sustaining benefits over time requires further investigation.
Unique Contribution to Theory, Practice and Policy: self-determination theory (SDT), social cognitive theory (SCT) & cognitive-behavioral theory (CBT) may be used to anchor future studies on the effectiveness of digital detox interventions in mitigating the negative effects of social media among adolescents and young adults. By identifying effective components and delivery methods of digital detox interventions, practitioners can design interventions that are feasible, acceptable, and sustainable within various settings, including schools, communities, and healthcare facilities. Research on the effectiveness of digital detox interventions has implications for policy development aimed at promoting healthier digital environments.
Research on the Synthesis Process of the Key Intermediate T18 in Nirmatrelvir
Authors: Zhang Mengyu 
Published: March 2024

The development of antiviral drugs against COVID-19 has attracted significant interest in recent years. Paxlovid, developed by Pfizer, is an orally administered small molecule drug for the treatment of COVID-19. It has attracted widespread attention due to its outstanding clinical performance. Nirmatrelvir, as the active ingredient of Paxlovid, has a huge market demand. Therefore, the development of a mild, efficient, and industrially feasible synthesis method for Nirmatrelvir is meaningful.
This study investigates the synthesis process of the key amide intermediate T18 in Nirmatrelvir. Various amide synthesis methods were attempted, and it was determined that the best result can be achieved by using HOPO as a catalyst and using EDCI as condensing agent. Based on this, detailed optimization of reaction parameters was carried out to further reduce the amount of HOPO and eliminate the use of ethyl acetate, methyl tert-butyl ether, brine and magnesium sulfate. Additionally, the post-treatment process was simplified, and a crystallization process more suitable for industrial production requirements was developed. These findings provide important technical support for the industrial production of Nirmatrelvir.