bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cleaning performance of bionic screen based on earthworm motion characteristics
Authors: Yu Yongtao , Li Yanjun , Xie Fuxiang , Song Jian 
Published: April 2024

Abstract

As the feeding mass of harvester continues to be increased, the accumulation of the maize mixture on the screen more serious, leading to a decrease in screening efficiency of the cleaning screen. The maize mixture on the screen was quickly transported backward through a bionic screen based on the motion characteristics of earthworms to reduce accumulation. However, the impact of the main operating parameters of this bionic screen on the cleaning performance was not yet clear. Therefore, the CFD-DEM were coupled for the simulation test. The quadratic orthogonal rotation combination test with three factors and five levels was conducted on the main operating parameters that affect the loss percentage and impurity percentage of maize grain in the cleaning device of bionic screen. Analysis of variance, regression and response surface were carried out on the test data, and the optimal parameter combination was obtained through parameter optimization: the concave depth of the screen surface was 25 mm, the installation angle of the screen surface was –5.5°, and the airflow velocity at the inlet of the cleaning device was 12.3 m·s-1. At this time, the lost percentage of maize grain was 1.56%, and the impurity percentage of maize grain was 1.85%, which met the requirements of national standards. The experiment provides reference and basis for the follow-up exploration of the screening mechanism of bionic screen.
Microstructural and Mechanical Behavior of Welds in Partially Transformed TRIP 800 Steel Produced by Friction Stir Spot Welding (FSSW)
Authors: Madureira Henderson Soares , Castro Carlos Alberto Carvalho Castro , Vaz Claudio Turani , Corrêa Elaine Carbalo Siqueira 
Published: April 2024

Abstract

The industry’s pursuit of clean technologies and materials amidst growing concerns about climate change underscores the significance of innovative welding processes. The utilization of TRIP 800 steel, renowned for its transformation-induced plasticity, highlights the endeavor towards enhancing energy efficiency and safety in the automotive sector. Nevertheless, welding this material poses significant challenges, particularly in the formation of martensitic regions in the weld zone, potentially resulting in reduced ductility and increased brittleness. Additionally, the thermal cycle involved in the welding process may induce unfavorable microstructural changes, affecting the overall integrity of the welded joint. Despite these challenges, FSSW emerges as a promising alternative to traditional welding processes, offering advantages such as reduced energy consumption and enhanced mechanical properties. This study aimed to investigate welds in TRIP 800 steel sheets through the Friction Stir Spot Welding (FSSW) process after deformation, thereby reflecting broader applications beyond vehicle manufacturing. The interaction of factors, including time and rotation speed, was examined at various levels for microstructural characterization, tensile and microhardness tests, showcasing the versatility and potential of the FSSW process. The analysis of welded joints revealed distinct regions such as the stir zone, thermomechanically affected zone, thermally affected zone, and base metal, illustrating the complexity and precision of modern welding techniques. Notably, the study delved into the microstructures of the affected zones, elucidating their pivotal role in influencing mechanical behavior under load conditions until failure. This investigation contributes to the ongoing quest for innovative solutions in vehicle manufacturing, emphasizing the importance of understanding welding processes and material properties in achieving sustainability and performance goals.
Nocardamine mitigates cellular dysfunction induced by oxidative stress in periodontal ligament stem cells
Authors: HE Hai-Peng , ZHAO Mei-Zhen , JIAO Wei-Hua , LIU Zhi-Qiang , ZENG Xian-Hai , LI Quan-Li , HU Tian-Yong , CHENG Bao-Hui 
Published: April 2024

Abstract

Background
The role of periodontal ligament stem cells (PDLSCs) in repairing periodontal destruction is crucial, but their functions can be impaired by excessive oxidative stress (OS). Nocardamine (NOCA), a cyclic siderophore, has been shown to possess anti-cancer and anti-bacterial properties. This study aimed to investigate the protective mechanisms of NOCA against OS-induced cellular dysfunction in PDLSCs.
Methods
The cytotoxicity of NOCA on PDLSCs was assessed using a CCK-8 assay. PDLSCs were then treated with hydrogen peroxide (H2O2) to induce OS. ROS levels, cell viability, and antioxidant factor expression were analyzed using relevant kits after treatment. Small molecule inhibitors U0126 and XAV-939 were employed to block ERK signaling and Wnt pathways respectively. Osteogenic differentiation was assessed using alkaline phosphatase (ALP) activity staining and Alizarin Red S (ARS) staining of mineralized nodules. Expression levels of osteogenic gene markers and ERK pathway were determined via real-time quantitative polymerase chain reaction (RT-qPCR) or western blot (WB) analysis. β-catenin nuclear localization was examined by western blotting and confocal microscopy.
Results
NOCA exhibited no significant cytotoxicity at concentrations below 20 µM and effectively inhibited H2O2-induced OS in PDLSCs. NOCA also restored ALP activity, mineralized nodule formation, and the expression of osteogenic markers in H2O2-stimulated PDLSCs. Mechanistically, NOCA increased p-ERK level and promoted β-catenin translocation into the nucleus; however, blocking ERK pathway disrupted the osteogenic protection provided by NOCA and impaired its ability to induce β-catenin nuclear translocation under OS conditions in PDLSCs.
Conclusions
NOCA protected PDLSCs against H2O2-induced OS and effectively restored impaired osteogenic differentiation in PDLSCs by modulating the ERK/Wnt signaling pathway.
Links between emotion word usage, accuracy, and emotional dysregulation: An integrative analysis
Authors: Fugate Jennifer , Gendron Maria , Hoemann Katie 
Published: April 2024

Abstract

People vary in the precision with which they report on their emotions, known as emotional granularity, and this precision predicts their ability to regulate their emotions. It is not yet known, however, whether links between emotion regulation and emotional granularity are due to variation knowledge of emotion words -- specifically, individuals’ reported usage, understanding, and ability to accurately define emotion words. In the present report, we combined data from six studies to address this gap in the literature using an integrative data analysis. Participants across the studies reported on their usage and understanding of a list of highly-granular emotion words, and were tested for their accuracy of definition. They also completed questionnaire measures of emotional granularity and emotion dysregulation. Emotion word accuracy and understanding were highly correlated, so individual models tested each separately to predict emotion regulation difficulty. In the model including usage and understanding, we observed a main effect of understanding, such that participants with greater self-assessed understanding of emotion words reported less difficulty regulating their emotions. Similar effects were found for the model including usage and accuracy, such that individuals with higher emotion word accuracy had less difficulty regulating their emotions. Critically, these findings held when accounting for self-reported granularity, suggesting the value of emotion word knowledge measures for predicting dysregulated emotions. Future work should examine how individuals’ emotion word knowledge is also linked to mental health outcomes.
Real-time Estimation of the Residual Moisture during Desorption with Temperature-based State Observers
Authors: Braatz Richard , Sris Prakitr , Barbastathis George 
Published: April 2024

Abstract

Monitoring the residual moisture during desorption is vital to ensuring the final product quality in many chemical processes. One particular application is the lyophilization of biotherapeutics, e.g., mRNA vaccines, in which the bound water is removed via desorption during secondary drying. Successful liquid removal provides long-term stability for the vaccines, allowing for storage at higher temperature. This article proposes a novel technique for real-time estimation of the residual moisture during desorption, with application to lyophilization. A state observer is employed, which combines temperature measurement and mechanistic understanding of heat transfer and desorption kinetics, without requiring any online concentration measurement. Results from both simulations and experimental data show that the observer can accurately estimate the concentration of bound water in real time for all possible concentration levels, operating conditions, and measurement noise. This framework represents the first state observer for monitoring and control of the residual moisture in desorption-related processes.
Exploring the potential mechanism of Polygonatum sibiricum for Alzheimer's disease based on network pharmacology and molecular docking
Authors: Luo Liangliang , Pan Yao , Chen Fang , Zhang Zhihong 
Published: April 2024

Abstract
Alzheimer's disease (AD) is a neurodegenerative disease, and there have been no systematic studies of Polygonatum against Alzheimer's disease. This study aimed to identify the primary active components and potential mechanisms of action of Polygonatum in the treatment of AD through network pharmacology and molecular docking. Polygonatum's active ingredients and corresponding targets were identified using the Traditional Chinese Medicine Systematic Pharmacology Database and Analysis Platform (TCMSP). Disease targets of Alzheimer's disease (AD) were retrieved from the therapeutic target database (TTD), Online Mendelian Inheritance in Man(OMIM), GeneCards, and Disgenet databases. We constructed protein interaction PPI networks and performed Gene Ontology (GO) functional enrichment analysis as well as Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis on common targets. As a result, a total of 10 active ingredients and 108 common targets were screened from Polygonatum. After analysis, 29 genes were identified as core genes. According to GO analysis, the core targets were found to be mainly involved in signal transduction, positive regulation of gene expression, and so on. The KEGG analysis revealed that the signaling pathways comprised pathways in cancer, pathways of neurodegeneration - multiple diseases, and PI3K-Akt signaling pathway. The molecular docking results indicated that ten of active ingredients from Polygonatum exhibited strong binding affinity with the six core targets that were screened before. This study confirms that the treatment of Alzheimer's disease with Polygonatum involves multi-targets and multi-pathway interactions, which provides a new perspective on the treatment of Alzheimer's disease and offers a theoretical basis for further research on the pathogenesis and treatment of AD.
Source and transport enrichment mechanism of iodine in shallow saline groundwater in Tianjin coastal area
Authors: Xie Dingsheng , Li Mengdi , Li Haiming , Su Sihui , Zhang Cuixia , Lv Shaoyan , Du Xiaorui 
Published: April 2024

Abstract

Iodine is one of the essential trace elements in the human body, and excessive or insufficient intake will affect human health. To ensure the safety of drinking water resources, the spatial distribution of iodine content and migration enrichment factors in shallow underground salty water in Tianjin coastal area were studied. The results show that the iodide content of shallow groundwater ranges from ND to 1320 μg/L, and high iodine groundwater (100-300 μg/L) and ultra-high iodine groundwater (>300 μg/L) account for 37.5%, distributed in the east, west, central and south of the study area; iodine-deficient groundwater (＜25 μg/L) accounts for 10%, and iodine-suitable groundwater (25-100 μg/L) accounts for 15%. From north to south and from northwest to southeast, the shallow groundwater in the study area changed from freshwater and brackish water to saline and salt water; the I- concentrations in freshwater, brackish water, and saltwater were significantly different, and the I- concentrations tended to increase with the increase of TDS concentration; the main hydrochemical types in this direction changed from HCO3·Ca-Na→Cl·SO4-Na·Mg→HCO3·Cl-Na·Ca→Cl·HCO3-Na→Cl-Na type shift; high iodine and ultra-high iodine groundwater chemistry types are mainly Cl-Na types, Cl·HCO3-Na type and HCO3-Ca·Na type. The main source of iodine in groundwater is marine sediments, and its enrichment mechanism is as follows: stronger reducing environment and groundwater flow promote the dissolution of carbonates containing Ca2+, HCO3-, SO42- and sulfate minerals, such as gypsum and manganese nitrate; sedimentary iodine is released in the process of dissolution of marine sediments and reduced to I-; I- migrates with the flow of groundwater; in the eastern part of the study area, the poor permeability of the In the eastern part of the study area, mucky clay is the main soil structure, and groundwater flow is blocked, so I- is enriched here, and the concentration increases under strong evaporation and concentration.
Correlation between gestational diabetes and peripartum mental disorders: A meta-analysis of 1,636,131 patients .Running title :A meta-analysis about correlation between gestational diabetes and peripartum mental disorders
Authors: Wan Qirong , Xie Haiying , Yuan Wei , Chen Zhenhua , Gao Yanhong , Wang Jing 
Published: April 2024

Abstract

Background and Aim
The relationship between gestational diabetes mellitus (GDM) and peripartum mental disorders is unclear. Hence, the current meta-analysis aimed to systematically evaluate the risk of mental disorders in pregnant women with or without GDM.
Methods
We searched the PubMed, Cochrane Library, EMBASE, and Web of Science databases for relevant articles published up to October 30, 2021. The random-effects or fixed-effects model was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the prevalence of mental disorders in GDM. Sensitivity and subgroup analyses were conducted to test the robustness of the pooled estimates.
Results
We analyzed 32 studies involving 1,636,131 pregnant women, and the results demonstrated that GDM significantly increased the prevalence of peripartum depression (antenatal, pooled OR: 1.57, 95% CI: 1.33–1.85, P < 0.05; postpartum, pooled OR: 1.42, 95% CI: 1.18–1.70, P < 0.05), especially in women from Asia (pooled OR: 2.71, 95% CI: 1.98–3.72, P < 0.05). Compared to pregnant women without GDM, women with GDM reported significantly higher anxiety scores (pooled OR: 4.19, 95% CI: 1.21–7.17, P = 0.006) but insignificantly on antenatal stress symptoms while this evidence still needs to be further strengthened.
Conclusions
GDM significantly increased the prevalence of antenatal and postpartum mental disorders. Further multi-center prospective studies with long-term follow-up are required to verify the association between GDM and mental health.
Persistent diagrams for protein structure prediction
Authors: LAMINE ZAKARIA 
Published: April 2024

Abstract
Topological approaches for protein structure analysis often comes with an input matrix describing the suitable filtration of our data and helping to choose adequate statistical tests to come up with a final shape by using an algebraic invariant, which is in our case a persistent diagram, we will be giving a theoretical description of this matrix through persistent homology, by investigating the data consisting of a point cloud generated from the PDB Ids 2JOX and 1COS.
[AMS classification]55N31, 62R40
Evaluation of a digital patient education programme in patients with coronary artery disease, a survey-based study
Authors: Sandberg Anna , Ravn-Fischer Annica , Johnsson Annika , Lachonius Maria , Bäck Maria 
Published: April 2024

Abstract

Introduction
Patient education programmes focusing on risk factor modification and lifestyle changes are well established as part of cardiac rehabilitation in patients with coronary artery disease (CAD). As participation rates are low, digital patient education programmes (DPE) are interesting alternatives to increase access. Understanding patients’ perceptions of DPE are important in terms of successful implementation in clinical practice but are not well known. Therefore, the aim of this study was to assess patients’ perceptions of using a DPE in terms of end-user acceptance and usability, perceived significance for lifestyle changes and secondary preventive goal fulfilment in patients with CAD.
Methods
This was a cross-sectional survey-based study. The survey was distributed to all 1625 patients with acute coronary syndrome or chronic CAD with revascularisation, who were registered users of the DPE between 2020–2022. The survey contained 64 questions about e.g., acceptance and usability, perceived significance for making lifestyle changes and secondary preventive goal fulfilment. Patients who had never logged in to the DPE received questions about their reasons for not logging in.
Results
A total of 366 patients (mean age: 69.1 ± 11.3 years, 20% female) completed the survey and among those 207 patients (57%) had used the DPE. Patients reported that the DPE was simple to use (80%) and improved access to healthcare (67–75%). A total of 69% of the patients were generally satisfied with the DPE, > 60% reported that the DPE increased their knowledge about secondary preventive treatment goals and approximately 60% reported having a healthy lifestyle today. On the other hand, 35% of the patients would have preferred a hospital-based education programme. Among the 159 patients (43%) who had never used the DPE, the most reported reason was a perceived need for more information about how to use the DPE (52%).
Conclusions
This study shows an overall high level of patient acceptance and usability of the DPE, which supports its continued development and long-term role in cardiac rehabilitation in patients with CAD. Future studies should assess associations between participation in the DPE and clinical outcomes, such as secondary preventive goal fulfilment and hospitalisation.
Cost analysis of integrating hypertension and diabetes management into routine HIV care in Mbarara and Ibanda districts, Uganda
Authors: Ninsiima Mackline , Basu Soumava , Husain Muhammad Jami , Kawungezi Peter Chris , Kabami Zainah , Simbwa Brenda Nakafeero , Bulage Lilian , Kruse Meredith , Tetlow Sonia , Kadobera Daniel , Ssali Mina , Mugisha Richard , Ario Alex Riolexus , Kostova Deliana 
Published: April 2024

Abstract

Background
In 2016, Uganda initiated integration of services for non-communicable diseases, including hypertension and diabetes, into existing HIV care services. However, this intervention has not been fully implemented yet in most HIV clinics. We evaluated the costs associated with scaling up hypertension and diabetes management services in selected HIV clinics in Mbarara and Ibanda districts, Uganda.
Methods
In March 2023, we obtained data on costs of providing hypertension and diabetes services in ten randomly selected HIV clinics in Mbarara and Ibanda districts including, healthcare providers’ salaries, time spent offering to these services, training costs, medications, and patient monitoring systems. Using the HEARTS costing tool, we estimated the annual costs of providing hypertension and diabetes services. We disaggregated annual costs by the domains of the HEARTS costing tool. We determined the average annual cost and medication expenses for hypertension and diabetes treatment per enrolled adult patient stratified by type of health facility.
Results
The total annual cost of hypertension and diabetes management services in ten selected HIV clinics was estimated to be $413,850 (range: $8,386 − 186,973). The annual average clinic-level cost per enrolled patient was estimated at $14 (range: $7 − 31). Of the total annual cost, the cost of provider time for initial and follow-up visits represented the largest cost component in 5/10 clinics (mean: 37%, range [13–58%]). In 4/10 clinics, the major cost components were the costs of medication, diagnostic tests, and related supplies (mean: 37%, range [10–75%]). The average cost per enrolled adult patient was $11 at public facilities and $21 in private not-for-profit facilities. The average medication cost per patient for hypertension was $24 (range: $7 − 97) annually; $13 at public facilities and $50 at private, not-for-profit facilities. For diabetes treatment, the average annual medication cost per patient was estimated at $14 (range: $6 − 35); $11 at public facilities and $22 at private not-for-profit facilities.
Conclusion
Integrating hypertension and diabetes management into routine HIV care might be feasible based on the estimated annual cost per patient. Hypertension and diabetes treatment was more costly in private not-for-profit facility-based clinics than at public facilities, primarily driven by the higher costs of medications.
Hyperbilirubinemia and Retinopathy of Prematurity: A Retrospective Cohort Study
Authors: Gulden Silvia , Cervellini Gaia , Colombo Marta , Marangoni Maria Beatrice , Taccani Vittoria , Pesenti Nicola , Raffaeli Genny , Araimo Gabriella , Osnaghi Silvia , Fumagalli Monica , Garrido Felipe , Villamor Eduardo , Cavallaro Giacomo 
Published: April 2024

Abstract

Purpose.
Retinopathy of prematurity (ROP) is a vasoproliferative retinal disease in preterm infants. Oxidative stress plays a key role in the pathogenesis of ROP. Bilirubin has been proposed to be protective against ROP due to its antioxidant effects. This study explored the association between hyperbilirubinemia and ROP.
Methods.
We analyzed a 10-year cohort from a neonatal intensive care unit in Milan, Italy, including 1606 infants born under 32 weeks and/or < 1500 g.
Results.
Data from 1606 infants meeting specific inclusion criteria were reviewed. Eighty infants were excluded due to lack of data, 1526 were deemed eligible for analysis, and 1269 had hyperbilirubinemia requiring phototherapy. There was a higher incidence of ROP among infants with hyperbilirubinemia (13.8%) versus those without (7.8%, p < 0.01). Infants with any ROP, non-severe or severe ROP, were exposed to hyperbilirubinemia for a significantly higher number of days compared with those without ROP. Each additional day of exposure increases the risk of developing any ROP by 5%, non-severe ROP by 4%, and severe ROP by 6%. However, this correlation was not observed in infants with gestational age less than 27 weeks and/or body weight less than 1000 g.
Conclusion.
Our data show that hyperbilirubinemia requiring phototherapy is associated with an increased risk of developing ROP. However, severe hyperbilirubinemia and ROP share many of their risk factors. Therefore, rather than being a risk factor itself, hyperbilirubinemia may be a surrogate for other risk factors for ROP.
Clinical Trial Registration: NCT05806684