bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eruptive Pseudoangiomatosis and Parvovirus: Exclusive Findings in Clinical Manifestation from a Report of Four Cases
Authors: Gaudiello Francesca , Spennato Serena , Cillo Francesco , Cantelli Maria Teresa , Vastarella Maria , Scalvenzi Massimiliano 
Published: April 2024

Introduction:
Eruptive pseudoangiomatosis (EP) is a rare type of cutaneous exanthema characterized by red angioma-like papules. An association of EP with viral infection has been reported.
We herein describe 4 pediatric patients who showed a new variant of EP-associated rash with atypical clinical features and positivity for parvovirus B19 infection.

Case presentation:
Pediatric patients showed a new variant of EP-associated rash with atypical clinical features by dermoscopy and reflectance confocal microscopy. The papules were localized to the face (cheeks, forehead, and eyelids).
Dermoscopy showed multiple red dots suggesting dilated capillaries surrounded by reddish structureless areas; and in vivo reflectance confocal microscopy (RCM) showed perivascular inflammation around the dermal papillae. However, characteristic perilesional halo was absent. In all patients, serology revealed evidence of active infection by parvovirus B19.

Discussion:
Few cases of a facial pseudoangiomatous rash that is related to parvovirus B19 infection and lacks the typical anemic halo have been reported in the literature.

Conclusion:
These cases provide new information on the clinical spectrum of EP and its association with parvovirus.
Professional Quality of Life and Turnover Intention in Forensic Nurse Program Coordinators: Implications to Forensic Nurse Workforce Development
Authors: Meyer Leigh Anne 
Published: April 2024

ABSTRACTBackgroundSignificant barriers to forensic nurse workforce development exist, affecting patient care access. Retention of forensic nurses is a persistent problem, and turnover of forensic nurses can be attributed to many factors related to professional quality of life, including compassion satisfaction (CS), burnout (BO), and secondary traumatic stress (STS).PurposeThe aim of this study was to identify the effect of an educational session on the topic of professional quality of life and strategies for mitigating the impact of stressors within the forensic nurse role on Professional Quality of Life Scale-5 and Turnover Intention Scale-6.MethodsA convenience sample of forensic nurse program coordinators was surveyed using a pretest–posttest quasi-experimental survey design. Correlation between professional quality of life indicators and turnover intention was explored.ResultsCohort (n= 38) preintervention CS levels were average to high (mean = 41.42), BO levels were average to low (mean = 22.53), and STS levels were average to low (mean = 22.89). Statistically significant positive correlations were noted between each Professional Quality of Life Scale indicator and turnover intention (CS:r= 0.59,p< 0.0001; BO:r= 0.98,p< 0.0000; STS:r= 0.67,p< 0.0000). A statistically significant decrease in BO level (α = 0.05,p= 0.0454) was noted postintervention.ImplicationsBO and STS had a strong positive correlation to turnover intention. BO levels decreased to a significant degree when reassessed 3 months after the educational intervention. Increased awareness of the impact of CS, BO, and STS could decrease BO in forensic nurses with potential reduction in turnover.
Large Medically Resistant Intramuscular Fast-Flow Vascular Anomaly in a Young Adult Patient Managed With Embolization and Cryoablation
Authors: Patel Kristy , Schoeman Sean , Cahill Anne Marie 
Published: April 2024

Background:
Mitogen-activated protein 2 kinase (MAP2K) intramuscular high-flow vascular anomaly is a benign vascular lesion, thought to be congenital, with an indolent course. Years after initial presentation, symptoms may manifest due to abrupt growth.

Case presentation:
This report describes a case of a young female who presented with a MAP2K high-flow vascular anomaly with recalcitrant pain, resistant to a trial of Sirolimus and Trametinib. Significant lesion size reduction and pain resolution were achieved with a combination of preablation embolization followed by cryoablation. Follow-up of 5 years informs lesion reduction and stability.

Conclusion:
Using a multi-method approach (embolization then ablation) can be considered in the treatment of MAP2K high-flow vascular malformations resistant to medical therapy.
The long-term efficacy of imatinib with hepatic resection or other local treatment for gastrointestinal stromal tumours liver metastases: a retrospective cohort study
Authors: Wen Haoxiang , Huang Yihao , Huang Shaoqing , Xiao Han , Xie Wenxuan , Zhou Qian , Tan Li , Ding Yuqi , Liu Xiaofei , Yu Yang , Song Zimin , Shen Shunli , Chen Zebin , Zhang Xinhua 
Published: April 2024

Background:
The liver is the most common site of metastasis from gastrointestinal stromal tumors (GISTs). The authors aimed to evaluate imatinib (IM) combined with hepatic resection (HR) or other local treatments such as radiofrequency ablation (RFA) and transarterial chemoembolization (TACE), compared to IM monotherapy in long-term survival benefits in patients suffering from GIST liver metastases.

Methods:
Our research encompassed 238 patients diagnosed with liver metastases of GISTs from January 2002 to April 2022 at the First Affiliated Hospital of Sun Yat-Sen University. The oncological outcomes of concern included overall survival (OS), progression-free survival (PFS), and liver-specific PFS.

Results:
Of all 238 patients, 126 were treated with IM alone (IM group), 81 with IM combined with HR (IM+HR group), and 31 with IM combined with RFA/TACE (IM+RFA/TACE group). The median follow-up time was 44.83 months. The median OS in the IM group was 132.60 months and was not reached in either the IM+HR group or the IM+RFA/TACE group. The 10-year OS rate in the IM+HR group was significantly superior to the IM group and the IM+RFA/TACE group (91.9% vs. 61.1% vs. 55.2%, respectively, P=0.015), and the liver-specific PFS (P=0.642) and PFS (P=0.369) in the three groups showed a beneficial trend in the combined treatment group. Multivariate analyses showed that age less than or equal to 60 years (HR 0.280, P<0.001) and IM+HR (HR 0.361, P=0.047) were independently associated with better OS. Achieving no evidence of disease through surgical intervention was independently correlated with enhanced OS (HR 0.099, P=0.034), liver-specific PFS (HR 0.388, P=0.014), and PFS (HR 0.402, P=0.004).

Conclusions:
In patients with GIST liver metastases, IM combined with HR might improve OS in selected patients compared with IM alone and IM combined with RFA/TACE. Achieving no evidence of disease status with surgical treatment of patients results in significant prolonging of OS, liver-specific PFS, and PFS.
In Patients With Inflammatory Bowel Disease, Racial Disparities Exist in Burden of Vaccine-preventable Disease Hospitalizations and Outcomes
Authors: Karime Christian , Salazar Miguel , Black Cecily N. , Caldera Freddy , Okafor Philip N. , Hammami Muhammad B. , Hashash Jana G. , Farraye Francis A. 
Published: April 2024

Objective:
Patients with inflammatory bowel disease (IBD) are at increased risk of vaccine-preventable diseases (VPDs). Despite the increasing prevalence of IBD in non-white populations, little is known regarding racial disparities in VPD burden.

Methods:
Retrospectively analyzing the 2016 to 2020 National Inpatient Sample, we identified adults with IBD hospitalized for a principal diagnosis of VPD. The primary outcome investigated was hospitalization for VPD stratified by patient-reported race. Secondary outcomes were in-hospital morbidity, mortality, length of stay, and health care utilization. Multivariable regression analysis was performed to adjust for patient and hospital characteristics.

Results:
The search identified 554,114 hospitalizations for VPD, including 4170 hospitalizations in patients with IBD. Patients with IBD had significantly greater odds of hospitalization from herpes zoster virus (adjusted odds ratio [aOR]: 1.73) and varicella zoster virus (aOR: 2.31). Comparing white and non-white patients with IBD, significant racial disparities were noted. Non-white patients were at greater odds of hospitalization from influenza (aOR: 1.74), herpes zoster virus (aOR: 1.77), and varicella zoster virus (aOR: 1.62). In-hospital morbidity was greater in non-white patients, including greater odds of requiring intensive care unit stay (aOR: 1.18). Morbidity was elevated in African Americans, with greater odds of acute kidney injury (aOR: 1.25), venous thromboembolism (aOR: 1.17), respiratory failure (aOR: 1.16), and intensive care unit stay (aOR: 1.18). No differences were found in mortality, length of stay, and health care utilization.

Conclusions:
Significant racial disparities in VPD hospitalization and in-hospital morbidity were found among adults with IBD in the United States. With the increasing prevalence of IBD in non-white populations, targeted efforts are needed to improve health equity.
Association Between Medicare’s Sepsis Reporting Policy (SEP-1) and the Documentation of a Sepsis Diagnosis in the Clinical Record
Authors: Barbash Ian J. , Davis Billie S. , Saul Melissa , Hwa Rebecca , Brant Emily B. , Seymour Christopher W. , Kahn Jeremy M. 
Published: April 2024

Study Design:
Interrupted time series analysis of a retrospective, electronic health record cohort.

Objective:
To determine the association between the implementation of Medicare’s sepsis reporting measure (SEP-1) and sepsis diagnosis rates as assessed in clinical documentation.

Background:
The role of health policy in the effort to improve sepsis diagnosis remains unclear.

Patients and Methods:
Adult patients hospitalized with suspected infection and organ dysfunction within 6 hours of presentation to the emergency department, admitted to one of 11 hospitals in a multi-hospital health system from January 2013 to December 2017. Clinician-diagnosed sepsis, as reflected by the inclusion of the terms “sepsis” or “septic” in the text of clinical notes in the first two calendar days following presentation.

Results:
Among 44,074 adult patients with sepsis admitted to 11 hospitals over 5 years, the proportion with sepsis documentation was 32.2% just before the implementation of SEP-1 in the third quarter of 2015 and increased to 37.3% by the fourth quarter of 2017. Of the 9 post-SEP-1 quarters, 8 had odds ratios for a sepsis diagnosis >1 (overall range: 0.98–1.26; P value for a joint test of statistical significance = 0.005). The effects were clinically modest, with a maximum effect of an absolute increase of 4.2% (95% CI: 0.9–7.8) at the end of the study period. The effect was greater in patients who did not require vasopressors compared with patients who required vasopressors (P value for test of interaction = 0.02).

Conclusions:
SEP-1 implementation was associated with modest increases in sepsis diagnosis rates, primarily among patients who did not require vasoactive medications.
Factor Xa inhibitors vs. warfarin in patients with Hughes syndrome: a systematic review and meta-analysis of randomized controlled trials
Authors: Mohtashim Ali , Azhar Aima , Mazhar Saad , Devi Deepa , Danial Muhammad , Patel Dhruvilkumar , Khan Owais , Andani Anushka , Khan Muhammad Mohib , Samad Shahzaib , Qureshi Aena , Ali Hafsa , Ejaz Umer , Jawad Sayed 
Published: April 2024

Background:
The optimal treatment regimen for patients with Hughes syndrome remains unclear. Therefore, the authors sought to compare the outcomes of warfarin vs. factor Xa inhibitors in patients with Hughes syndrome.

Methods:
MEDLINE, Embase, and Cochrane Central databases were searched for randomized controlled trials (RCTs) comparing 8 efficacy and safety of warfarin and factor Xa inhibitors in patients with Hughes syndrome. Recurrent thrombosis, all-cause mortality, stroke, adverse reactions, and bleeding were among 10 outcomes of interest. Mantel–Haenszel weighted random-effects model was used to calculate 11 relative risks (RRs) with 95% CIs.

Results:
The analysis included 625 patients from four RCTs and one post-hoc analysis. Meta-analysis showed a statistically non-significant difference between factor Xa inhibitors and warfarin in the recurrent thrombosis risk (arterial or venous) [RR 2.77 (95%, CI 0.79, 9.65); P=0.11, I2=50%]. Consistent results were revealed among patients with a previous history of arterial thrombosis [RR 2.76 (95% CI 0.93, 8.16); P=0.75, I2=0%], venous thrombosis [RR 1.71 (95% CI 0.60, 4.84); P=0.31, I2=15%] and patients who were triple antiphospholipid antibodies (aPL) positive [RR 4.12 (95% CI 0.46, 37.10); 21 P=0.21, I2=58%]. Factor Xa inhibitors were significantly associated with an increased risk of stroke [RR 8.51 (95% CI 2.35, 13.82); P=0.47, I2=0%].

Conclusion:
Factor Xa inhibitors exhibited an increased risk of stroke among patients with Hughes syndrome. In addition, although not significant, the higher RRs among patients on factor Xa inhibitors may indicate a higher risk of thrombotic events associated with factor Xa inhibitors.
Effects of Cutting Planes on Costal Cartilage Warping
Authors: Ratanapoompinyo Sanathorn , Kiranantawat Kidakorn 
Published: April 2024

Background:
Autogenous costal cartilage becomes a favorable choice for nasal reconstruction and complicated aesthetic rhinoplasty, because of its ample supply, sufficient for most patients. However, a notable drawback is the potential for warping. The authors’ study aims to identify cutting planes that minimize warping.

Methods:
Two hundred seven costal cartilage grafts were obtained by slicing the extracted costal cartilages from 10 fresh cadavers along 3 main planes: cephalocaudal, anteroposterior, and parallel to the synchondrosis plane. Each of these major planes was further divided into grafts taken from both the central and peripheral portions. Furthermore, both subgroups were categorized into three thicknesses: 1, 2, and 3 mm. The warping angles of all grafts were then compared at various time intervals after the initial cutting.

Results:
Cephalocaudal cuts exhibited significantly greater warping than other planes. Anteroposterior cuts displayed the least warping, although this difference lacked statistical significance. Peak warping occurred at 30 minutes. Certain grafts continued to warp even at 1 month. Central grafts had less warping than peripheral ones, although the difference was not statistically significant.

Conclusions:
Cephalocaudal cuts yielded the highest warping angle. Surgeons seeking thin (<3 mm) straight grafts should opt for anteroposterior or parallel to synchondrosis planes. Thicker grafts (>3 mm) can be cut in the cephalocaudal plane with an acceptable warping angle, close to parallel with the synchondrosis plane. For curved cartilage, thin cephalocaudal cutting is recommended. In addition, the authors suggest placing the cartilage in normal saline for at least 30 minutes, allowing for maximum warping to occur.
Incidental Finding of Spindle Cell Sarcoma on 68Ga-PSMA-11 PET/CT
Authors: Anigati Elena M. , Nguyen Nghi C. 
Published: April 2024

Abstract
A 78-year-old man underwent 68Ga–prostate-specific membrane antigen-11 (PSMA-11) PET/CT for biochemical recurrence of prostate adenocarcinoma following a simple prostatectomy. The scan showed PSMA-avid local recurrence within the prostatectomy bed and a suspicious right internal iliac nodal metastasis. In addition, there was a mildly avid subcutaneous lesion in the right flank, which revealed high-grade spindle cell sarcoma at histopathology. This case represents a potential pitfall for PSMA-11 PET imaging. The presentation of mildly avid, atypical soft tissue lesions should warrant a biopsy to allow for proper diagnosis and treatment management.
Isolation of Bioactive Compounds from Low-cost Agricultural Resources and its Utilization in Daily Life.
Authors: Debnath Anirban , Das Arpita 
Published: April 2024

The ethanolic (80%), methanolic (80%) and aqueous decoction (100% distilled water) of whole plant of Oxalis corniculata Linn (Indian Sorrel) was evaluated for its anti‐microbial and antioxidant properties by in vitro methods. Methanolic (80%) and ethanolic (80%) decoctions showed significant antibacterial property against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi bacterial strains. In comparison to Chloramphenicol (C30) against bacteria, 80% ethanolic decoctions showed significant effect, among the decoctions. Nowadays though the standard soap is in a huge demand but it’s also facing major backlashes due to the presence of synthetic compounds in it, which over long use may cause harmful effects on the skin health. Therefore, the organic soaps which are made up of natural ingredients, herbs or any sort ayurvedic compound have less side effects on the human skin and are much safer than standard daily soap. The formulated therapeutic soap exhibits significant amount of reducing potential (high FRAP and TAC values) and antioxidant activity (DPPH, ABTS assay).
Audio-visual concert performances synchronize an audience’s heart rates
Authors: Czepiel Anna M. , Fink Lauren K. , Scharinger Mathias , Seibert Christoph , Wald-Fuhrmann Melanie , Kotz Sonja A. 
Published: April 2024

AbstractPeople enjoy engaging with music. Live music concerts provide an excellent option to investigate real-world music experiences, and at the same time, use neurophysiological synchrony to assess dynamic engagement. In the current study, we assessed engagement in a live concert setting using synchrony of cardiorespiratory measures, comparing inter-subject, stimulus-response, correlation, and phase coherence. As engagement might be enhanced in a concert setting byseeingmusicians perform, we presented audiences with audio-only (AO) and audio-visual (AV) piano performances. Only correlation measures were above chance level. In comparing time-averaged synchrony across conditions, AV performances evoked higher inter-subject correlation of heart rate (ISC-HR). However, self-reported engagement did not correspond to synchrony when averaged across music pieces. On the other hand, time-resolved analyses show that synchronized deceleration-acceleration heart rate (HR) patterns, typical of an ‘orienting response’ (an index of directed attention), occurredwithinmusic pieces at salient events of section boundaries. That is, seeing musicians perform heightened audience engagement at structurally important moments in Western classical music. Overall, we could show that multisensory information shapes dynamic engagement. By comparing different synchrony measures, we further highlight the advantages of timeseries analysis, specifically ISC-HR, as a robust measure of holistic musical listening experiences in naturalistic concert settings.
Pleasurable music activates cerebral μ-opioid receptors: A combined PET-fMRI study
Authors: Putkinen Vesa , Seppälä Kerttu , Harju Harri , Hirvonen Jussi , Karlsson Henry K. , Nummenmaa Lauri 
Published: April 2024

AbstractThe μ-opioid receptor (MOR) system mediates incentive motivation and the hedonic component of primary rewards such as food and sex. However, there is no directin vivoevidence for the involvement of the MOR system in pleasure derived from aesthetic rewards such as music. We measured MOR activation with positron emission tomography (PET) and the agonist radioligand [11C] carfentanil with high affinity for MORs during the listening of pleasurable music and neutral baseline condition. Haemodynamic responses to pleasurable music were measured using functional magnetic resonance imaging (fMRI). The PET results revealed that pleasurable music increased [11C]carfentanil binding in several cortical and subcortical regions, including ventral striatum and orbitofrontal cortex, known to contain “hedonic hotspots”. Individual variation in baseline MOR tone influenced pleasure-dependent haemodynamic responses during music listening in regions associated with interoceptive, sensorimotor, and reward processing. Our results provide the first-ever neuroimaging evidence that listening to pleasurable music modulates MOR system activation and indicate that the μ-opioid system governs complex aesthetic rewards in addition to biologically salient primary rewards.
Diversity of the non-biting midges (Diptera: Chironomidae) in continental salt marshes in Serbia
Authors: Stamenković Olivera , Čerba Dubravka , Đurđević Aca , Koh Miran 
Published: April 2024

AbstractContinental salt marshes represent specific inland saltwater bodies with unique ecological characteristics a fact that is mirrored by specific flora and fauna. However, there is still limited data on their biota in Serbia, which is especially true for aquatic macroinvertebrates, including chironomids (Diptera: Chironomidae). Here we investigated diversity and seasonal variations of chironomid community in six salt marshes distributed in the northern and southern part of Serbia. We recorded a total of 25 species, of which two are new for the Serbian chironomid fauna. Most of the recorded species are common in freshwaters and several of them are halotolerant. Chironomid community structure fluctuated in relation to the seasons. The highest diversity was recorded in the spring and summer months for the majority of studied salt marshes. The present findings should contribute to the knowledge of the faunistic composition of salt marshes in Serbia and provide a basis for future distributional and ecological studies of chironomids.
Extracellular vesicles from preeclampsia disrupt the blood-brain barrier via reduced claudin-5: potential role of vascular endothelial growth factor
Authors: Sandoval Hermes , Ibañez Belén , Contreras Moisés , Troncoso Felipe , Castro Fidel O , Caamaño Diego , Mendez Lidice , Escudero-Guevara Estefanny , Mistry Hiten D. , Kurlak Lesia O. , Vatish Manu , Acurio Jesenia , Escudero Carlos 
Published: April 2024

AbstractBackgroundPhysiopathology of life-treating cerebrovascular complications in preeclampsia are yet unknown. We investigated whether disruption of the blood-brain barrier (BBB), generated using circulating small extracellular vesicles (sEVs) from women with preeclampsia or placentae cultured under hypoxic conditions, impairs the expression of tight junction proteins, such as claudin 5 (CLDN5), mediated by VEGF and activation of VEGF receptor 2 (KDR).MethodssEVs were isolated from plasma (normal pregnancy, sEVs-NP, n=9); preeclampsia, sEVs-PE, n=9) or placental explants from normotensive pregnancies, cultured in normoxia (sEVs-Nor, n=10) or hypoxia (sEVs-Hyp, n=10). The integrity of the BBB was evaluated usingin vitro(human and mice brain endothelial cell lines) andin vivo(non-pregnant C57BL/6 mice (4 to 5 months old, (n=10) were injected with sEVs-Hyp), models.ResultssEVs-PE and sEVs-Hyp reduced CLND5 levels (p<0.05) in the endothelial cell membrane without affecting other tight junction proteins. These results were negated with sEVs-PE sonication. sEVs-Hyp injected into non-pregnant mice generated neurological deficits and BBB disruption, specifically in the posterior area of the brain, associated with reduction in CLND5 levels in the brain cortex. Furthermore, sEVs-PE and sEVs-sHyp had higher VEGF levels than sEVs-NP and sEVs-Nor, respectively. Human brain endothelial cells exposed to sEVs-PE or sEVs-sHyp exhibited a reduction in the activation of KDR.ConclusionsEVs from hypoxic placentae and plasma from women with preeclampsia disrupt the BBB, via reduction of CLDN5, a phenomenon that may involve VEGF contained within these vesicles. These findings will improve the elucidation of cerebrovascular alterations in women with preeclampsia.