bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on Friction and Wear Behaviors of Different Solid Lubricant Coatings on Aluminum-Based Piston Skirts
Authors: Wang Jingsi , Teng Dezhi , Zhang Yuan , Sa Xiaoxia , Li Chengdi , Cui Qihang , Fan Jiawei 
Published: March 2024

Abstract
Stringent requirements in emissions drive the application of low-carbon fuel engines, which result in prominent friction and lubrication problems in the cylinder. Solid coating technology is an effective way to enhance the tribological performance of tribo-pairs and has great potential to solve friction and lubricant problems. In this work, graphite, molybdenum disulfide (MoS2), and tungsten disulfide (WS2) solid lubricant coatings were prepared on aluminum-based piston skirts, respectively. The friction and wear behaviors of three coatings were investigated using a self-designed piston skirt friction and wear apparatus. The chemical products generated on the worn surfaces were analyzed, and the combined effect of lubricating oil and solid lubricant coatings was confirmed. The results show that the solid coatings can effectively enhance the friction and wear characteristics of piston skirt-cylinder liner tribosystem, and WS2 coating has the best anti-friction and wear-resistant performance among the three coatings.
First-Line Anlotinib Treatment for Soft-Tissue Sarcoma in Chemotherapy-Ineligible Patients: An Open-Label, Single-Arm, Phase 2 Clinical Trial
Authors: Li Tao , Dong Ying , Wei Yongzhong , Wang Shoufeng , Liu Yunxia , Chen Jia , Xiong Wenhua , Lin Nong , Huang Xin , Liu Meng , Yan Xiaobo , Ye Zhaoming , Li Binghao 
Published: March 2024

Abstract

Purpose:
Standard treatment for patients with unresectable locally advanced or metastatic soft-tissue sarcoma (LA/M STS) is chemotherapy based on anthracyclines, but patient tolerance of chemotherapy is limited. The present trial (NCT03792542) investigated the use of anlotinib as first-line treatment for patients with advanced STS, in particular liposarcoma.

Patients and Methods:
Eligible patients were previously untreated, pathologically confirmed, unresectable LA/M STS cases. Anlotinib was given orally at a dose of 12 mg once daily from days 1 to 14 every 3 weeks until disease progression or intolerable adverse events (AE) occurred. The primary endpoint was progression-free survival (PFS), and the secondary endpoints were overall survival (OS), objective response rate, and disease control rate (DCR). The safety profile was also evaluated.

Results:
Forty patients were enrolled from April 2019 to June 2022 and are included in the intention-to-treat analysis. The median PFS was 6.83 months [95% confidence interval (CI), 4.17–8.71] and the median OS 27.40 months (95% CI, 16.43–not evaluable); 1 patient reached partial response and 26 attained stable disease, with a DCR of 67.5% (27/40). Median PFS and OS times for liposarcoma patients were 8.71 and 16.23 months, respectively. Ten (25.0%) patients had treatment-related AEs ≥ grade 3, with in particular a higher incidence of hypertension (15.0%) and proteinuria (7.5%).

Conclusions:
The findings suggest a potential benefit in using front-line anlotinib to treat patients with STS, who are not eligible for cytotoxic chemotherapy. Of note, the clinical outcomes for the liposarcoma subgroup of patients were encouraging.
See related commentary by Napolitano et al., p. 4257
Is There Imminent Expectation in 1 Thess 4:13–18?
Authors: Gathercole Simon 
Published: March 2024

Abstract
This article will question the conventional view according to which 1 Thess 4:13–18 shows evidence of Paul’s Naherwartung. Although Paul’s expectation of an imminent end is usually assumed to be the default interpretation of 1 Thess 4:15, 17, it actually rests on certain presuppositions about the Greek syntax of these verses in two respects. First, the usual interpretation assumes εἰς τὴν παρουσίαν τοῦ κυρίου as functioning a certain way, although an alternative is equally possible. Secondly, a family of related alternative interpretations understands “who are left (to the Lord’s parousia)” as modifying “we, the living” in some sort of limiting way. After disentangling the proposed alternatives and evaluating the component interpretations, the article will show that there are in fact several plausible interpretations of 1 Thess 4:15, 17, of which the Naherwartung view is only one.
Jesus’s Puzzling Retort to the Royal Official (John 4:48) in Isodiegetic Perspective
Authors: Berglund Carl Johan 
Published: March 2024

Abstract
When a “royal official” (βασιλικός) urges Jesus to help his dying son, Jesus surprisingly retorts (John 4:48): “Unless you people see signs and wonders, you will never believe!” Researchers find this outburst out of place in response to a desperate father, but this article argues that it can be explained by use of an isodiegetic perspective, where the Johannine storyworld is informed by a larger narrative tradition in which the tetrarch Herod Antipas (ca. 4 BCE–39 CE) is a known adversary of Jesus, whose adherents strive to entrap him and get him killed. In view of the official’s expected patronal loyalty to “king” (βασιλεύς) Herod, his healing request can reasonably be presumed to be a trap until his appeal “Sir, come down before my child dies!” (John 4:49) clarifies that the man is not acting as a client, but as a father.
Textual Criticism in the Gaps
Authors: McCollum Joey 
Published: March 2024

Abstract
This article concerns the likelihoods of competing textual reconstructions in the Chester Beatty Papyrus 𝔓⁴⁶ based on the available space in its lacunose lines. To quantify these relative probabilities, the author uses statistical models of line lengths in 𝔓⁴⁶ and a recently described technique for calculating the likelihood of a reconstructed lacunose text. He first demonstrates the power and versatility of this approach with examples in Gal 4:17 and 3:1. He then revisits two more contested textual reconstructions proposed for 𝔓⁴⁶: the absence of τῷ θεῷ in Heb 11:4, suggested by G.D. Kilpatrick in 1941, and the absence of σὺν ἐπισκόποις καὶ διακόνοις in Phil 1:1, suggested by T.C. Skeat in 1995. He shows that Kilpatrick’s proposed shorter reading in 𝔓⁴⁶ is six times more likely than the longer reading in Heb 11:4, while the evidence is not decisive between the readings in Phil 1:1.
The Curious Personality Cult of Abu Bakr Al-Baghdadi: At the Crossroads of Religion, Politics, and Communication Strategies and Technologies
Authors: Salih Mohammed A. 
Published: March 2024

Abstract
This paper studies the construction of the personality cult of Abu Bakr al-Baghdadi, the deceased leader of the Islamic State (is) organization that ruled large territories in Iraq and Syria in the mid to late 2010s. Examining a range of is primary sources, I argue that al-Baghdadi sought to develop a distinct personality cult by cultivating auras of holiness and mystique around his personae. While he flaunted putatively exceptional religious leadership credentials, it is al-Baghdadi’s use of communication strategies and technologies for projecting his personality cult that distinguishes his case and this study. Al-Baghdadi sought to strategically mystify himself by rarely appearing in public and largely avoiding visual self-revelation in the media messages he released. Ultimately, given his defiance of regional and international powers and his group’s notoriety, al-Baghdadi’s low visibility and self-enigmatization worked to his advantage by generating much interest about him among supporters and the global media.
Role of particle gradation of clay–sand mixtures on the interfacial adhesion performance of polymer coatings
Authors: Murali Nidhi , Li Jing , Agarwal Anvi , Berthault Patrick , Ghosh Pijush 
Published: March 2024

AbstractThe interface performance between clay–sand mixtures and concrete structures is governed by the mixture's composition and its physical properties. Moisture content and particle-size distribution play important roles in deciding the mixture's arrangement of soil particles, porosity, hydraulic conductivity and behaviour under various mechanical loadings. Application of a polymer interfacial coating can improve the bond performance between soils and concrete mainly via interfacial friction/mechanical interlocking. The present work analyses the development of interfacial strength between clay–sand mixtures and a polymer coating with changes in particle gradation. The multi-scale mechanisms at the interface are investigated, giving primary attention to soil porosity. A 50:50 clay–sand mixture exhibited a greater interfacial adhesive performance compared to other soil mixtures. In addition, the moisture-controlled pores and gradation-controlled pores demonstrated differences in macroscale interfacial strength. Both mercury intrusion porosimetry (MIP) and 129Xe nuclear magnetic resonance (NMR) were utilized to detect the pore structure of the mixtures. 129Xe-NMR revealed the pore distribution of the mixtures as ranging from macropores to nanopores, and MIP complemented the pore information by determining the critical pore entry diameter in the macropore regime. Mesopores dominated with increasing fine sand content until a threshold value was reached; thereafter, merging of pores occurred and macropores dominated.
Formation of iron-rich phyllosilicates in the FeO–SiO2–H2O system during hydrothermal synthesis as a function of pH
Authors: Dzene Liva , Doggaz Amira , Dutournié Patrick , Inoué Sayako , Abdelmoula Mustapha , Jourdain Alexandra , Le Meins Jean-Marc , Brendlé Jocelyne , Martin Christelle , Michau Nicolas 
Published: March 2024

AbstractThe formation of iron-rich phyllosilicates can occur at different natural or engineered settings. In this study, the influence of pH in the hydrothermal synthesis of iron-rich phyllosilicates was investigated in the pH range 8.50–12.10 after the ageing of the precursor. The synthesized samples were characterized by powder X-ray diffraction, Raman and Mössbauer spectroscopies and transmission electron microscopy. Three domains of pH were identified, and these correlated with silica availability and its speciation in the solution. The formation of 1:1-type FeIII/FeII phyllosilicate was observed between pH 9.67 and 10.75. Above pH 10.75, two types of phyllosilicate-like mineral phases were observed. In addition to 1:1-type FeIII/FeII phyllosilicate, 2:1-type FeIII/FeII phyllosilicate was observed. Below pH 9.67, mainly amorphous silica and iron oxides were observed. The findings show that pH governed the crystallinity and nature of the obtained phyllosilicate-like phases.
HIV protease resistance mutations in patients receiving second-line antiretroviral therapy in Libreville, Gabon
Authors: Nzengui-Nzengui Guy Francis , Mourembou Gaël , M’boyis-Kamdem Hervé , Kombila-Koumavor Ayawa Claudine , Ndjoyi-Mbiguino Angélique 
Published: March 2024

Abstract
Introduction
In 2022, the WHO reported that 29.8 million people around the world were living with HIV (PLHIV) and receiving antiretroviral treatment (ART), including 25‌ 375 people in Gabon (54% of all those living with HIV in the country). The literature reports a frequency of therapeutic failure with first-line antiretrovirals (ARVs) of between 20% and 82%. Unfortunately, data relating to the failure of second-line ARVs are scarce in Gabon. This study aims to determine the profiles of HIV drug resistance mutations related to protease inhibitors in Gabon.

Methodology
Plasma from 84 PLHIV receiving ARVs was collected from 2019 to 2021, followed by RNA extraction, amplification, and sequencing of the protease gene. ARV resistance profiles were generated using the Stanford interpretation algorithm version 8.9-1 (https://hivdb.stanford.edu) and statistical analyses were performed using EpiInfo software version 7.2.1.0 (CDC, USA).

Results
Of 84 HIV plasma samples collected from 45 men and 39 women, 342 mutations were detected. Of these, 43.3% (148/342) were associated with nucleoside reverse transcriptase inhibitors (NRTIs), 30.4% (104/342) with non-nucleoside reverse transcriptase inhibitors (NNRTIs), and 26.3% (90/342) with protease inhibitors (PIs). Most NRTI mutations were associated with thymidine analogues (TAMs) (50.7%; 75/148), including T215F/V (14.9%; 22/148), D67DN/E/G/N/T (10.1%; 15/148), M41L (9.5%; 14/148), and K70E/KN/S/R (9.5%; 14/148). Resistance mutations related to non-TAM NRTIs (33.1%; 49/148) were M184V (29.1%; 43/148), and L74I/V (8.1%; 12/148). NNRTI mutations were predominantly K103N/S (32.7%; 34/104), V108I (10.6%; 11/104), A98G (10.6%; 11/104), and P225H (9.6%; 10/104). Minor mutations associated with PIs (60.0%; 54/90) were predominantly K20I (15.6%; 14/90) and L10F/I/V (14.5%; 13/90). The major mutations associated with PIs (40.0%; 36/90) were M41L (12.2%; 11/90), I84V (6.7%; 06/90), and V82A (6.7%; 06/90). The four most prescribed therapeutic regimens were TDF + 3TC + LPV/r (20.3%; 17/84), ABC + DDI + LPV/r (17.9%; 15/84), TDF + FTC + LPV/r (11.9%; 10/84), and ABC + 3TC + LPV/r (11.9%; 10/84).

Conclusion
This study revealed that HIV drug resistance mutations are common in Gabon. The major mutations associated with PIs were M41L, I84V, and V82A. There is a need for access to new NRTIs, NNRTIs, and PIs for a better therapeutic management of PLHIV in Gabon.
Assisting primary care teams and patients in a culturally diverse periphery: impact on medical students’ future career choices
Authors: Rayan-Gharra Nosaiba , Malatskey Lilach , Ofir-Gutler Marganit , Sakhnini Rizan , Yousef Awni , Khatib Mohammad , Skorecki Karl , Spitzer Sivan 
Published: March 2024

Abstract
Background
Medical students can assist in reducing healthcare disparities and promote health equity by engaging with rural communities and gaining insights into their unique healthcare needs. A two-arm student-delivered program was designed and implemented during COVID-19 in a social-geographic peripheral area to assist clinics with complex chronic and/or socially disadvantaged patients and improve preventive behavior in townships through home visits delivering community kits.

Methods
We conducted a pre-post design study which included weekly structured medical student reports and monthly structured telephone interviews with clinic directors and municipal partners. Students completed pre-post program survey on their knowledge, skills, and capabilities to address chronic patients from diverse cultural backgrounds (n = 73). The Wilcoxon-Signed-Rank test for related samples was used to determine differences.

Results
Following the program, the knowledge and awareness levels of students about working in the community (P < 0.001) and their knowledge of common chronic diseases were significantly improved (Mean Difference (MD) = 0.31; p < 0.001). The program significantly increased students’ interest to integrate into community care alongside a hospital (P = 0.012). Thematic analysis of student reports revealed improved insight into the role of primary care. Clinic directors (90%) were highly satisfied and reported that students became an integral part of the clinics’ teams.

Conclusions
Integrating medical students into the community through primary-care clinics and home visits in diverse communities, exposed students to the interwoven effect of clinical and social determinants on health and improve their knowledge of common chronic diseases. Participation in the program encouraged students to consider a career in community care.
Long-term follow-up of 109 children with juvenile idiopathic oligoarthritis after first intra-articular corticosteroid injection
Authors: Zajc Avramovič Mojca , Toplak Nataša , Markelj Gašper , Emeršič Nina , Avčin Tadej 
Published: March 2024

Abstract
Background
To evaluate long-term outcomes and prognostic factors in patients with juvenile idiopathic arthritis (JIA), presenting as oligoarthritis, who received IAC as the first treatment for their disease.

Methods
We conducted retrospective study at the University Children’s Hospital Ljubljana, Slovenia, from January 2015 to May 2023 in children with JIA, clinically presenting as oligoarthritis receiving intra-articular corticosteroid injection (IAC) as the initial treatment. Patient and treatment data were collected, and the outcomes were categorized into three groups based on the later need for therapy: no therapy needed, only additional IAC needed and systemic therapy needed. The last group was further divided based on the requirement of bDMARD. Log-rank (Mantel-Cox) survival analyses compared different outcome groups.

Results
We included 109 patients with JIA, presenting as oligoarthritis (63% female), who were first treated with IAC. The mean age at IAC was 8.0 years, with a 4.3-year follow-up. Notably, 38.5% of patients did not require additional therapy post-IAC, whereas 15.5% required only additional IAC. Systemic therapy, mainly methotrexate (MTX), was necessary for 45.9% of patients, initiated in average 7.8 months post-IAC. Biologic therapy was initiated in 22% in average 2.2 years post-IAC. Number of injected joints correlated with the need for biologics. At the last follow-up, 88.9% had inactive disease. ANA positivity (P = 0.049, chi square 3.89) and HLA B27 antigen presence (P = 0.050, chi square 3.85) were associated with the need for systemic therapy. A subgroup of children older than 8 years, ANA and HLA B27 negative required significantly less systemic (25.8%) and biologic therapy (9.6%) compared to other patients (p = 0.050, chi square 3.77).

Conclusion
Almost 40% of children with oligoarticular JIA requiring IAC did not progress to chronic disease. Younger age, ANA positivity, and HLA B27 presence were predictive factors for systemic therapy, while the number of injected joints predicted the future need for biologic therapy.
Effectiveness of extracellular vesicles derived from hiPSCs in repairing hyperoxia-induced injury in a fetal murine lung explant model
Authors: Saneh Hala , Wanczyk Heather , Walker Joanne , Finck Christine 
Published: March 2024

Abstract
Background
Despite advances in neonatal care, the incidence of Bronchopulmonary Dysplasia (BPD) remains high among preterm infants. Human induced pluripotent stem cells (hiPSCs) have shown promise in repairing injury in animal BPD models. Evidence suggests they exert their effects via paracrine mechanisms. We aim herein to assess the effectiveness of extracellular vesicles (EVs) derived from hiPSCs and their alveolar progenies (diPSCs) in attenuating hyperoxic injury in a preterm lung explant model.

Methods
Murine lung lobes were harvested on embryonic day 17.5 and maintained in air–liquid interface. Following exposure to 95% O2 for 24 h, media was supplemented with 5 × 106 particles/mL of EVs isolated from hiPSCs or diPSCs by size-exclusion chromatography. On day 3, explants were assessed using Hematoxylin–Eosin staining with mean linear intercept (MLI) measurements, immunohistochemistry, VEGFa and antioxidant gene expression. Statistical analysis was conducted using one-way ANOVA and Multiple Comparison Test. EV proteomic profiling was performed, and annotations focused on alveolarization and angiogenesis signaling pathways, as well as anti-inflammatory, anti-oxidant, and regenerative pathways.

Results
Exposure of fetal lung explants to hyperoxia induced airspace enlargement, increased MLI, upregulation of anti-oxidants Prdx5 and Nfe2l2 with decreased VEGFa expression. Treatment with hiPSC-EVs improved parenchymal histologic changes. No overt changes in vasculature structure were observed on immunohistochemistry in our in vitro model. However, VEGFa and anti-oxidant genes were upregulated with diPSC-EVs, suggesting a pro-angiogenic and cytoprotective potential. EV proteomic analysis provided new insights in regard to potential pathways influencing lung regeneration.

Conclusion
This proof-of-concept in vitro study reveals a potential role for hiPSC- and diPSC-EVs in attenuating lung changes associated with prematurity and oxygen exposure. Our findings pave the way for a novel cell free approach to prevent and/or treat BPD, and ultimately reduce the global burden of the disease.
Learnt representations of proteins can be used for accurate prediction of small molecule binding sites on experimentally determined and predicted protein structures
Authors: Carbery Anna , Buttenschoen Martin , Skyner Rachael , von Delft Frank , Deane Charlotte M. 
Published: March 2024

AbstractProtein-ligand binding site prediction is a useful tool for understanding the functional behaviour and potential drug-target interactions of a novel protein of interest. However, most binding site prediction methods are tested by providing crystallised ligand-bound (holo) structures as input. This testing regime is insufficient to understand the performance on novel protein targets where experimental structures are not available. An alternative option is to provide computationally predicted protein structures, but this is not commonly tested. However, due to the training data used, computationally-predicted protein structures tend to be extremely accurate, and are often biased toward a holo conformation. In this study we describe and benchmark IF-SitePred, a protein-ligand binding site prediction method which is based on the labelling of ESM-IF1 protein language model embeddings combined with point cloud annotation and clustering. We show that not only is IF-SitePred competitive with state-of-the-art methods when predicting binding sites on experimental structures, but it performs better on proxies for novel proteins where low accuracy has been simulated by molecular dynamics. Finally, IF-SitePred outperforms other methods if ensembles of predicted protein structures are generated.
Improving assessment of procedural skills in health sciences education: a validation study of a rubrics system in neurophysiotherapy
Authors: Garcia-Ros Rafael , Ruescas-Nicolau Maria-Arantzazu , Cezón-Serrano Natalia , Flor-Rufino Cristina , Martin-Valenzuela Constanza San , Sánchez-Sánchez M. Luz 
Published: March 2024

Abstract
Background
The development of procedural skills is essential in health sciences education. Rubrics can be useful for learning and assessing these skills. To this end, a set of rubrics were developed in case of neurophysiotherapy maneuvers for undergraduates. Although students found the rubrics to be valid and useful in previous courses, the analysis of the practical exam results showed the need to change them in order to improve their validity and reliability, especially when used for summative purposes. After reviewing the rubrics, this paper analyzes their validity and reliability for promoting the learning of neurophysiotherapy maneuvers and assessing the acquisition of the procedural skills they involve.

Methods
In this cross-sectional and psychometric study, six experts and 142 undergraduate students of a neurophysiotherapy subject from a Spanish university participated. The rubrics’ validity (content and structural) and reliability (inter-rater and internal consistency) were analyzed. The students’ scores in the subject practical exam derived from the application of the rubrics, as well as the rubrics’ criteria difficulty and discrimination indices were also determined.

Results
The rubrics´ content validity was found to be adequate (Content Validity Index > 0.90). These showed a unidimensional structure, and an acceptable internal consistency (α = 0.71) and inter-rater reliability (Fleiss’ ƙ=0.44, ICC = 0.94). The scores of the subject practical exam practically covered the entire range of possible theoretical scores, showing all the criterion medium-low to medium difficulty indices - except for the one related to the physical therapist position-. All the criterion exhibited adequate discrimination indices (rpbis > 0.39), as did the rubric as a whole (Ferguson’s δ = 0.86). Students highlighted the rubrics´ usefulness for learning the maneuvers, as well as their validity and reliability for formative and summative assessment.

Conclusions
The changed rubrics constitute a valid and reliable instrument for evaluating the execution quality of neurophysiotherapy maneuvers from a summative evaluation viewpoint. This study facilitates the development of rubrics aimed at promoting different practical skills in health-science education.