bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly sensitive and selective laser-based BTEX sensor for occupational and environmental monitoring
Authors: Mhanna Mhanna , Sy Mohamed , Arfaj Ayman , Llamas Jose , Farooq Aamir 
Published: March 2024

A mid-infrared laser-based sensor is designed and demonstrated for trace detection of benzene, toluene, ethylbenzene, and xylene isomers at ambient conditions. The sensor is based on a distributed feedback inter-band cascade laser emitting near 3.29 µm and an off-axis cavity-enhanced absorption spectroscopy configuration with an optical gain of 2800. Wavelength tuning and a deep neural network (DNN) model were employed to enable simultaneous and selective BTEX measurements. The sensor performance was demonstrated by measuring BTEX mole fractions in various mixtures. At an integration time of 10 s, minimum detection limits of 11.4, 9.7, 9.1, 10, 15.6, and 12.9 ppb were achieved for benzene, toluene, ethylbenzene, m-xylene, o-xylene, and p-xylene, respectively. The sensor can be used to detect tiny BTEX leaks in petrochemical facilities and to monitor air quality in residential and industrial areas for workplace pollution.
3.73  W all-solid-state dual-wavelength Nd:Lu2O3 crystal laser
Authors: Zhu Yingjie , Qi Yan , Yan Boxia , Yin Yanru , Fan Yuanyuan , Zhang Jing 
Published: March 2024

The laser output characteristics of Nd:Lu2O3 crystals were investigated in detail to obtain a dual-wavelength all-solid-state laser. Using 806 nm LD end-face pumped Nd:Lu2O3 crystals with lengths of 6 mm, a 1076 & 1080 nm laser outputs with a maximum output power of 3.73 W were obtained, with a slope efficiency of 30.4%, an optical-to-optical conversion efficiency of 28.5%, and a power stability of 0.41% for 4 h of continuous measurement. Furthermore, by suppressing the higher-order modes, a high beam quality laser output with beam quality factors of 2.092 and 1.589 in the x and y directions, respectively, and a maximum output power of 1.27 W were obtained. In addition, it was experimentally verified that both wavelengths of the output laser were elliptically polarized.
Multifunction and switchable hybrid metasurface based on graphene and gold
Authors: Sajjad Muhammad , Kong Xiangkun , Liu Shaobin , Irshad Khan Muhammad 
Published: March 2024

This paper presents the design and numerical investigation of a graphene-based switchable terahertz (THz) metasurface for ultrawideband absorption and multiband cross polarization conversion. The device’s operational mode can be altered to absorption or reflection by using the electrostatic capabilities exhibited by graphene. The numerical calculations yield results indicating that in absorption mode, it maintains a bandwidth ratio of 152% within the frequency range of 1.04–7.74 THz. In polarization conversion mode, the design demonstrates the ability to convert linearly polarized and circularly polarized waves to their respective cross-polarization states within the frequency ranges of 1.8–2.5 THz, 3.5–4.1 THz, and 5.6 THz. Moreover, calculated results indicate that linear-to-circular conversion can be realized at 2.64, 3.45, and 5.4 THz frequencies. In addition, the absorption and polarization conversion ratio parameters were analyzed using the multiple reflection theory, which demonstrated significant agreement with the simulation results. The designed metasurface exhibits significant potential in the field of terahertz devices, including stealth technology, smart switches, and other related applications.
Post-treatment with maropitant reduces oxidative stress, endoplasmic reticulum stress and neuroinflammation on peripheral nerve injury in rats
Authors: Niella Raquel Vieira , Corrêa Janaína Maria Xavier , dos Santos João Felipe Ribeiro , Lima Larissa Ferreira , Marques Claire Souza da Costa , Santos Luciano Cardoso , Santana Larissa Rodrigues , Silva Álvaro José Chávez , Farias Keilane Silva , Pirovani Carlos Priminho , Silva Juneo Freitas , de Lavor Mário Sérgio Lima 
Published: March 2024

Objective
To determine the effective dose and therapeutic potential of maropitant using through expression of mediators of oxidative stress, inflammatory and of the unfolded protein response (UPR) (bio) markers on spinal cord using a model of neuropathic pain induced through chronic constriction injury (CCI) in rats.

Study design
Randomized, blinded, prospective experimental study.

Animals
98 male Wistar rats.

Methods
Rats were anesthetized with sevoflurane and after CCI, they were randomly assigned to the following groups that received: vehicle, 3, 6, 15, 30 e 50 mg/kg/24q of maropitant. The effect on inflammatory mediators (IL10, TNFα), oxidative stress (GPx, CAT, SOD), microglial (IBA-1) and neuronal (NeuN, TACR1) markers was evaluated though immunohistochemistry and expression levels of markers of hypoxia (HIF1α, Nrf2), antioxidant enzymes (Catalse, Sod1 and GPx1), and endoplasmic reticulum stress mediators (GRP78, CHOP and PERK) through qRT-PCR.

Results
Intraperitoneal injection (IP) of maropitant inhibited nociception with ID50 values of 4,1 mg/kg (5,85–19,36) in a neuropathic pain model through CCI. A dose of 30 mg/kg/24q was significantly effective in reducing mechanical allodynia 1 to 4h after treatment with nociception inhibition (145,83%). A reduction in the expression of hypoxia factors (HIF1α, Nrf2) was observed, along with an increase in antioxidant activity (CAT, SOD and GPX). Additionally, there was a reduction in inflammatory markes (IL10, TNFα), microglial (IBA-1), and neuronal markers (NeuN, TACR1).

Conclusion and clinical relevance
These findings demonstrate that the determined dose, administered daily for seven days, had an antinociceptive effect, as well as anti-inflammatory and antioxidant activity.
Cohort profile: Life-course experiences and pregnancy (LEAP)–A retrospective pregnancy cohort for life-course reproductive health research
Authors: Mason Susan M. , Farkas Kriszta , Friedman Jessica K. , Gerlach Anne , Johnson Sydney T. , Tavernier Rebecca Emery , Bodnar Lisa M. , Neumark-Sztainer Dianne 
Published: March 2024

Background
Life course factors may be associated with pre-pregnancy body mass index and gestational weight gain; however, collecting information on pre-pregnancy exposures and pregnancy health in the same cohort is challenging.

Objectives
The Life-course Experiences And Pregnancy (LEAP) study aims to identify adolescent and young adult risk factors for pre-pregnancy weight and gestational weight gain (GWG). We built upon an existing cohort study to overcome challenges inherent to studying life course determinants of pregnancy health.

Population
Participants in an ongoing prospective cohort study of weight-related health who identified as women.

Design
Retrospective cohort study.

Methods
In 2019–2020, 1,252 women participating since adolescence in a cohort study of weight-related health were invited to complete an online reproductive history survey. Participants who reported a live birth were invited to release their prenatal, delivery, and postpartum medical records for validation of survey reports. Descriptive analyses were conducted to assess the characteristics of the overall cohort and the medical record validation subsample, and to describe adolescent and young adult characteristics of those with high (>80th percentile), moderate (20th-80th percentile), and low (<20th percentile) GWG z-score for gestational age and pre-pregnancy weight status.

Preliminary results
Nine hundred seventy-seven women (78%) completed the LEAP survey and 656 reported a live birth. Of these, 379 (58%) agreed to release medical records, and 250 records were abstracted (66% of the 379). Of the 977 survey respondents 769 (79%) reported attempting a pregnancy, and 656 (67%) reported at least one live birth. The validation subsample was similar to the overall cohort. Women with a high GWG had a higher adolescent BMI percentile and prevalence of unhealthy weight control behaviors than those with moderate or low GWG.

Conclusions
LEAP offers a valuable resource for identifying life course factors that may influence the health of pregnant people and their offspring.
Musculoskeletal pain affects the age of retirement and the risk of work cessation among older people
Authors: Niederstrasser Nils Georg , Wainwright Elaine , Stevens Martin J. 
Published: March 2024

Objectives
Many people with chronic pain cannot work, while working despite chronic pain is linked to absenteeism and presenteeism and a host of other deleterious effects. This disproportionately affects older adults, who are closer to retirement, while the exact relationship between pain and work cessation as well as retirement among older adults is not known. We explore longitudinally the relationship between chronic pain and the risk of ceasing work and entering retirement.

Methods
Data from 1156 individuals 50 years or older living in England taking part in the English Longitudinal Study of Ageing were used in this study. Cox proportional hazards regression analyses were used to examine the nature of the relationship between musculoskeletal pain and work cessation as well as retirement longitudinally over the course of fourteen years.

Results
Suffering from frequent musculoskeletal pain was associated with an increased risk of ceasing work and retiring at an earlier age, as did work dissatisfaction, higher perceived social status, female gender, and not receiving the recognition they felt they deserved in their job. Severity of depressive symptoms, psychosocial job demands, decision authority, and social support did not influence the age at which participants reported work cessation or retirement.

Conclusions
Frequent musculoskeletal pain may increase the risk of earlier work exit and earlier retirement. Further research should establish the mechanisms and decision making involved in leaving the workforce in people with frequent musculoskeletal pain.
Accurate and reproducible enumeration of CD4 T cell counts and Hemoglobin levels using a point of care system: Comparison with conventional laboratory based testing systems in a clinical reference laboratory in Cameroon
Authors: Sagnia Bertrand , Mbakop Ghomsi Fabrice , Moudourou Sylvie , Gutierez Ana , Tchadji Jules , Sosso Samuel Martin , Ndjolo Alexis , Colizzi Vittorio 
Published: March 2024

Background
Measurements of CD4 T cells and hemoglobin (Hb) are conventionally used to determine the immunological state and disease progression for HIV-infected patients. We obtained a small lightweight point-of-care device, the BD FACSPrestoTM in order to demonstrate its ability to deliver CD4 and Hb analysis in comparison with two larger clinical machines the BDFACSCantoTM analyzer and Sysmex XN 1000 haematology analyzer. The advantages of using the POC device include access to HIV patient data in remote and in resource limited settings.

Method
The analytical performance of the BD FACSPrestoTM, compared with the FACSCantoTM II flow cytometer and the Sysmex XN 1000 haematology analyzer was evaluated by testing 241 routine clinical specimens collected in EDTA tubes from patients attending the Immunology and Microbiology laboratory of Chantal BIYA International Reference Centre (Yaounde, Cameroon) between January and May 2016.

Results
The mean in absolute counts and percentage of CD4 T cells was 606 cells/mL and 25% respectively via the FACSPrestoTM, and 574 cells/mL and 24% respectively via the BD FACSCantoTM II. The mean concentration of Hb levels was 11.90 on the Sysmex XN 1000 and 11.45 via the BD FACSPrestoTM, A high correlation (R2 = 0.95, P < 0.001) of Hb level measurements was noted between the BD FACSPrestoTM and Sysmex XN 1000 hematology analyzer. Overall, a Bland-Altman plot of the differences between the two methods showed an excellent agreement for absolute and percentage CD4 counts and hemoglobin measurements between POC and conventional methods evaluated here. Furthermore, the study demonstrated the ease of use of the BD FACSPrestoTM POC technology in remote areas.

Conclusion
The BD FACPrestoTM is a suitable tool for CD4 enumeration in resource-limited settings, specifically providing a deployable, reliable POC testing option. The BD FACSPrestoTM performed appropriately in comparison to the conventional reference standard technologies. The BD FACSPrestoTM, system provides accurate, reliable, precise CD4/%CD4/Hb results on venous blood sampling. The data showed good agreement between the BD FACSPrestoTM, BD FACSCantoTM II and Sysmex XN 1000 XN 1000 systems.
Cytokine and T cell responses in post-chikungunya viral arthritis: A cross-sectional study
Authors: Chang Aileen Y. , Tritsch Sarah R. , Herrera Gomez Carlos Andres , Encinales Liliana , Cadena Bonfanti Andres , Rosales Wendy , Mendoza-Torres Evelyn , Simmens Samuel , Amdur Richard L. , Mores Christopher N. , Fierbaugh Paige , Perez Hernandez Carlos Alberto , Avendaño Geraldine , Silvera Paula Bruges , Crespo Yerlenis Galvis , Jimenez Alberto David Cabana , Martinez Zapata Jennifer Carolina , Jimenez Dennys , Osorio-Llanes Estefanie , Castellar-Lopez Jairo , Suchowiecki Karol , Martins Karen , Gregory Melissa , Zuluaga Ivan , Proctor Abigale , Hernández Alfonso Sucerquia , Sierra-Carrero Leandro , Colpas Maria Villanueva , Hernandez Juan Carlos Perez , Quast Andres Alberto Figueroa , De Barros Joaquin Andres Calderon , Mejía José Forero , Ruiz Johan Penagos , Boyle David , Firestein Gary S. , Simon Gary L. 
Published: March 2024

Objective
To define the relationship between chronic chikungunya post-viral arthritis disease severity, cytokine response and T cell subsets in order to identify potential targets for therapy.

Methods
Participants with chikungunya arthritis were recruited from Colombia from 2019–2021. Arthritis disease severity was quantified using the Disease Activity Score-28 and an Arthritis-Flare Questionnaire adapted for chikungunya arthritis. Plasma cytokine concentrations (interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, interferon-γ and tumor necrosis factor (TNF)) were measured using a Meso Scale Diagnostics assay. Peripheral blood T cell subsets were measured using flow cytometry.

Results
Among participants with chikungunya arthritis (N = 158), IL-2 levels and frequency of regulatory T cells (Tregs) were low. Increased arthritis disease activity was associated with higher levels of inflammatory cytokines (IL-6, TNF and CRP) and immunoregulatory cytokine IL-10 (p<0.05). Increased arthritis flare activity was associated with higher Treg frequencies (p<0.05) without affecting T effector (Teff) frequencies, Treg/Teff ratios and Treg subsets. Finally, elevated levels of IL-2 were correlated with increased Treg frequency, percent Tregs out of CD4+ T cells, and Treg subsets expressing immunosuppressive markers, while also correlating with an increased percent Teff out of live lymphocytes (p<0.05).

Conclusion
Chikungunya arthritis is characterized by increased inflammatory cytokines and deficient IL-2 and Treg responses. Greater levels of IL-2 were associated with improved Treg numbers and immunosuppressive markers. Future research may consider targeting these pathways for therapy.
How does a motor or cognitive dual-task affect our sense of upper limb proprioception?
Authors: Ager Amanda L. , Cools Ann M. , Borms Dorien , Roy Jean-Sébastien 
Published: March 2024

Background
Daily upper limb activities require multitasking and our division of attention. How we allocate our attention can be studied using dual-task interference (DTi). Given the vital role proprioception plays in movement planning and motor control, it is important to investigate how conscious upper limb proprioception is impacted by DTi through cognitive and motor interference.

Purpose
To examine how dual-task interference impacts conscious upper limb proprioception during active joint repositioning tasks (AJRT).

Methods
Forty-two healthy participants, aged between 18 and 35, took part in this cross-sectional study. Participants completed two AJRT during three conditions: baseline (single task), dual-cognitive task (serial subtractions), and dual-motor task (non-dominant hand movements). The proprioceptive error (PE; difference between their estimation and targeted position) was measured using an AJRT of 75% and 90% of maximum internal rotation using the Biodex System IIITM and the Upper Limb Proprioception Reaching Test (PRO-Reach). To determine if PEs differed during dual-task interference, interference change scores from baseline were used with one sample t-tests and analyses of variance.

Results
The overall mean PE with the Biodex was 4.1° ± 1.9 at baseline. Mean change scores from baseline reflect a mean improvement of 1.5° ± 1.0 (p < .001) during dual-cognitive task and of 1.5° ± 1.2 (p < .001) during dual-motor task. The overall mean PE with the PRO-Reach was 4.4cm ± 1.1 at baseline. Mean change scores from baseline reflect a mean worsening of 1.0cm ± 1.1 (p < .001) during dual-cognitive task and improvement of 0.8cm ± 0.6 (p < .001) during dual-motor task. Analysis of variance with the Biodex PEs revealed an interference effect (p < .001), with the cognitive condition causing greater PEs compared to the motor condition and a criterion position effect (p = .006), where 75% of maximum IR produced larger PEs during both interference conditions. An interference effect (p = .022) with the PRO-Reach PEs was found highlighting a difference between the cognitive and motor conditions, with decreased PEs during the contralateral motor task.

Conclusion
Interference tasks did impact proprioception. Cognitive interference produced mixed results, whereas improved proprioception was seen during motor interference. Individual task prioritization strategies are possible, where each person may choose their own attention strategy when faced with dual-task interference.
Association of antihypertensives and Parkinson’s disease in a primary care population matched for underlying diagnosis
Authors: Schrag Anette , Kostev Karel 
Published: March 2024

Purpose
To examine the association of several antihypertensive medication classes with incidence of Parkinson’s disease (PD), taking into account possible underlying conditions.

Methods
In a case-control study based on a large primary care database and including 21,981 PD cases and 21,981 non-PD controls matched for age, sex, and possible treatment indications associations with different antihypertensive medication groups, including diuretics, betablockers, calcium channel blockers, angiotensin-converting enzyme inhibitors and angiotensin-II receptor-blockers and PD were examined.

Results
Antihypertensive medications overall were associated with a lower risk of subsequent diagnosis of PD (OR: 0.94, 95% CI 0.90–0.97), with the negative association most significant for medications acting on the renin–angiotensin–aldosterone system. A positive association with diagnosis of PD was only seen for betablockers and restricted to those with relatively young age and not in those with longer treatment duration.

Conclusion
When taking into account underlying diagnoses, antihypertensive medications overall were associated with a reduced incidence of PD.
Antihypertensive medication persistence and adherence among non-Hispanic Asian US patients with hypertension and fee-for-service Medicare health insurance
Authors: Choi Eunhee , Mizuno Hiroyuki , Wang Zhixin , Fang Chloe , Mefford Matthew T. , Reynolds Kristi , Ghazi Lama , Shimbo Daichi , Muntner Paul 
Published: March 2024

Background
Less than 50% of non-Hispanic Asian adults taking antihypertensive medication have controlled blood pressure.

Methods
We compared non-persistence and low adherence to antihypertensive medication between non-Hispanic Asian and other race/ethnicity groups among US adults ≥66 years who initiated antihypertensive medication between 2011 and 2018 using a 5% random sample of Medicare beneficiaries (non-Hispanic Asian, n = 2,260; non-Hispanic White, n = 56,000; non-Hispanic Black, n = 5,792; Hispanic, n = 4,212; and Other, n = 1,423). Non-persistence was defined as not having antihypertensive medication available to take in the last 90 of 365 days following treatment initiation. Low adherence was defined as having antihypertensive medication available to take on <80% of the 365 days following initiation.

Results
In 2011–2012, 2013–2014, 2015–2016 and 2017–2018, the proportion of non-Hispanic Asian Medicare beneficiaries with non-persistence was 29.1%, 25.6%, 25.4% and 26.7% (p-trend = 0.381), respectively, and the proportion with low adherence was 58.1%, 54.2%, 53.4% and 51.6%, respectively (p-trend = 0.020). In 2017–2018, compared with non-Hispanic Asian beneficiaries, non-persistence was less common among non-Hispanic White beneficiaries (risk ratio 0.74 [95%CI, 0.64–0.85]), non-Hispanic Black beneficiaries (0.80 [95%CI 0.68–0.94]) and those reporting Other race/ethnicity (0.68 [95%CI, 0.54–0.85]) but not among Hispanic beneficiaries (1.04 [95%CI, 0.88–1.23]). Compared to non-Hispanic Asian beneficiaries, non-Hispanic White beneficiaries and beneficiaries reporting Other race/ethnicity were less likely to have low adherence to antihypertensive medication (relative risk 0.78 [95%CI 0.72–0.84] and 0.84 [95%CI 0.74–0.95], respectively); there was no association for non-Hispanic Black or Hispanic beneficiaries.

Conclusions
Non-persistence and low adherence to antihypertensive medication were more common among older non-Hispanic Asian than non-Hispanic White adults.