bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trisomy 21 in bone marrow cells of a patient with a prolonged preleukemic phase
Authors: Sikand G. S. , Taysi K. , Strandjord S. E. , Griffith R. , Vietti T. J. 
Published: February 2007

AbstractThe clinical, hematologic, and cytogenetic findings are described in a patient who developed clinical and hematologic features of acute myelogenous leukemia (AML) after a three‐year period of observation with unexplained thrombocytopenia. Five months before the diagnosis of AML she developed hepatosplenomegaly and a lupus‐like syndrome. At this time she was also found to have trisomy 21 in all bone marrow cells studied, in addition to trisomy 8 in a few cells. The finding of trisomy 21 in all of the bone marrow cells examined could reflect a nonrandom alteration in the leukemic stem line or it might indicate that mosaic patients with trisomy 21 cells in their bone marrow share the increased risk of AML that has been documented for trisomy 21 patients.
Malignant histiocytosis in adults: Report of 7 patients from north east Italy
Authors: Carbone Antonino , Tirelli Umberto , Volpe Rachele , Veronesi Andrea , Galligioni Enzo , Trovò Mauro G. , Tumolo Salvatore , Grigoletto Eligio 
Published: February 2007

AbstractThe clinical records and histologic material of seven adult male patients with malignant histiocytosis (MH), observed consecutively at our center during a four‐year period, have been reviewed; four of these cases were seen in a year. All patients were born and lived within a radius of 30 miles from Pordenone, a town in northeast Italy. The diagnosis of MH was made in all cases on lymph node biopsy on the basis of the established histologic criteria [1]. At presentation, abnormal histiomonocytic cells were found in the bone marrow and peripheral blood of four patients, two of whom also showed cerebrospinal fluid involvement with atypical histiocytes at a relatively early stage of the disease. Staging procedures documented extensive disease in lymphatic, as well as in extralymphatic, sites in four patients; in three patients, the disease was confined to the lymphatic system. Combination chemotherapy was the first treatment employed in all cases. Four patients, three of whom had limited disease, achieved complete remission with quadruple combination chemotherapy (ABVD, CHOP, or MOPP); three patients with extensive disease achieved only partial remission of short duration with HOP. These results further support the view that adult MH is not obligatorily and rapidly fatal. Good responses to treatment with combination chemotherapy are possible, particularly in patients with disease limited to only lymphatic sites.
Intensive chemotherapy for metastatic neuroblastoma: A southwest oncology group study
Authors: Nitschke R. , Cangir A. , Crist W. , Berry D. H. 
Published: February 2007

AbstractThirty‐three children with Evans stage IV neuroblastoma were treated with an intensive chemotherapy regimen reported by Helson to be highly effective. The purpose of the study was to determine whether the toxic regimen was manageable by different investigators and to increase the sample of patients. Remission induction therapy consisted of courses repeated every four weeks: Cyclophos‐phamide (CTX) 80 mg/kg IV, with IV fluids and furosemide on days 1 and 2; vincristine (VCR) 0.03 mg/kg IV 12 hours after cyclophosphamide; trifluoro‐methyl‐2‐deoxyridine (F3TdR) 45 mg/kg IV push, and papaverine (PAP) 45 mg/kg (12‐hour infusion) under cardiac monitoring on days 3 and 4. Initially during maintenance, courses of therapy were reduced to two days. Because this was found to be ineffective therapy, the courses were extended to four days. Some of the patients who achieved response were removed from the protocol and placed on different maintenance therapy. Seventeen of 21 children newly diagnosed and 6/12 children previously treated for metastatic neuroblastoma achieved partial or complete remissions. Eight of 16 newly diagnosed patients achieving response are still alive, six without evidence of disease for periods of time ranging from 20 to 41 months. The median of the administered drug dosages was 100% of the recommended dosages. Seventy percent of the 229 courses given were initiated at correct interval. Therapy had to be delayed on the others because of toxicity. The value of the four‐drug combination is limited because of side effects related to myelosuppression which resulted in severe complications and frequent hospitalizations.
Myelopoiesis in immunologically classified subgroups of childhood acute lymphocytic leukemia
Authors: Crist William M. , Ragab Abdelsalem H. , Vogler Larry , Lui Victor K. S. , Castleberry Robert P. , Findley Harry W. , Merijanian Greg 
Published: February 2007

AbstractSoft agar culture studies of 43 immunologically characterized patients with childhood acute lymphocytic leukemia (ALL) are presented. The immunologic subsets studied include “null”‐cell, pre‐B‐cell, and T‐cell leukemias. Abnormal myelopoiesis, including high peripheral blood and low marrow, colony‐forming cell numbers, low colony‐stimulating activity, and normal maturation of colony‐forming cells in vitro was noted in each group as previously described for immunologically uncharacterized ALL. We conclude that immunologic subsets of childhood lymphoblastic leukemia cause similar abnormalities of myelopoiesis. Lack of differences in growth characteristics among immunologic subsets of ALL make it impossible to use this tissue culture technique in sub‐classification of these leukemic disorders.
A randomized study of intermittent chemotherapy with or without BCG inoculation in maintenance therapy of childhood ALL
Authors: Ekert H. , Waters K. D. , Matthews R. N. , Tauro G. P. , Rice M. S. , Seshadri R. , Mauger D. C. , Tiernan J. R. , McWhirter W. R. , O'Regan P. , Olsen T. E. , Mathews J. D. 
Published: February 2007

AbstractOne hundred ninety‐six children with acute lymphocytic leukemia were entered into a randomized study of maintenance chemotherapy with either intermittent chemotherapy and immunotherapy with bacillus Calmette‐Guerin (BCG) or only intermittent chemotherapy. On admission to the study, patients were stratified into three prognostic categories on the basis of clinical and laboratory features at presentation. Patients considered to have a favorable prognosis (PF) were induced with vincristine and prednisone; those with an unfavorable prognosis (PU) received combination chemotherapy consisting of either Ara‐C, cyclophosphamide and asparaginase, or vincristine, prednisolone, and daunomycin followed by Ara‐C and asparaginase; those with an average prognosis (PA) received vincristine and prednisolone followed by a single course of Ara‐C and asparaginase. All patients received central nervous system prophylaxis with 2,400 rad cranial irradiation and four injections of intrathecal methotrexate. One hundred seventy‐seven patients (90%) achieved complete remission, and 165 were randomized. Those randomized to Group A (83) received maintenance chemotherapy with six‐week courses of 6‐mercaptopurine, weekly oral methotrexate, and monthly vincristine. Each six‐week course was followed by a two‐week interval of no chemotherapy, and treatment was con tinued for 36 months. Patients randomized to Group B (82) received the same maintenance chemotherapy, but during the two‐week interval without chemotherapy, they were given BCG inoculation. With a median follow‐up of 110 weeks, no significant difference in duration of remission, survival, or CNS relapse was found between Groups A and B in the total patient population or within each prognostic category. In patients classified as PU, a significantly lower proportion (P < 0.02) remained in complete remission. Within this group, patients with a white cell count > 100 × 109/L had a significantly shorter duration of remission (P < 0.05). Patients classified as PF showed a This research was done by the Australasian Cancer Society Childhood Leukemia Group.
Acute lymphocytic leukemia developing in a male with germ cell carcinoma: A case report
Authors: Johnson Douglas C. , Luedke Dan W. , Sapiente Ronald A. , Naidu R. G. 
Published: February 2007

AbstractA case of germ cell carcinoma (of presumed testicular origin) is described in which acute lymphocytic leukemia developed within nine months of the diagnosis. Possible relationships between the two neoplasms are discussed, as well as the need for continued observation of patients with germ cell tumors as they are living longer and may be at higher risk for developing a second cancer.
The relevance of platelet and fibrinogen kinetics and coagulation studies to extent of disease and performance status in patients with adenocarcinoma
Authors: Williams C. K. O. , Pineo G. F. , Gallus A. S. , McCulloch P. B. 
Published: February 2007

AbstractIn this study of 18 cancer patients, results of laboratory evaluation of a “hyper‐coagulable state” have been correlated with the extent of the disease and the functional activity of the patients. Most coagulation tests were normal. Higher levels of serum fibrinogen degradation products were associated with wider dissemination of disease. Fibrinogen survival time (t 1/2) was shorter in patients with extensive disease than in those with less extensive disease (P < 0.05); platelet t1/2 was also shorter in the former group, though not significantly. Coexistence of severest physical disability and extensive disease was associated with the most marked reduction of platelet and fibrinogen t1/2. There was little correlation between platelet and fibrinogen t1/2, thus suggesting independent mechanisms of destruction of the two blood components. We suggest that future studies of hemostatic changes in cancer patients should include assessment of impairment of physical performance of the patients, as well as the extent of the tumor.
Reactivation of hand‐schüller‐christian disease six and thirteen years after discontinuation of systemic therapy
Authors: Grimm Ruby A. , Muss Hyman B. , Patterson Richard B. , Weathers Dwight R. , White Janis P. , Medford Houck M. 
Published: February 2007

AbstractWe present two cases of reactivation of Hand‐Schüller‐Christian disease or multifocal eosinophilic granuloma 6 and 13 years after discontinuation of systemic therapy. Both patients received oral therapy with methotrexate and prednisone continuing for 2—3 years after the disease was thought to be in remission. Relapses were detected because of disease symptoms and treated with surgery with or without radiation. Neither patient has required reinstitution of systemic therapy. These cases are cited as evidence of the chronicity of the disorder and as a reminder that reactivation is possible after years of disease inactivity. Therefore, long‐term clinical follow‐up of patients in remission is indicated.
Leptomeningeal carcinomatosis in small cell carcinoma of the lung
Authors: Aisner Joseph , Ostrow Stanley , Govindan Srinivasan , Wiernik Peter H. 
Published: February 2007

AbstractAmong 137 patients with small cell carcinoma of the lung (SCCL) treated on two consecutive protocols, leptomeningeal metastases were documented in 12 patients (9%), 10 antemortem by cerebrospinal fluid (CSF) cytology, one by myelogram, and one only at necropsy. Signs and symptoms included confusion in seven, limb weakness in six, paresthesias in three, headache in two, urinary incontinence in two, and nausea and vomiting, diplopia and neck pain in one patient each. Nine of the 12 patients had evidence of other metastases while three patients relapsed first in the CSF and one had disease only in the leptomeninges. Treatment for this complication including irradiation, intrathecal chemotherapy, or systemic chemotherapy was generally ineffective with a median duration of survival of 50 days (range 5 to 130) after diagnosis of leptomeningeal. Necropsies showed thick tumor deposits along cord, distal nerve roots, cauda equina, and in Virchow—Robbins spaces with deep invasion into adjacent neural substance in six of the seven. Leptomeningeal involvement appears to have become manifest as median survival has increased. CSF cytology should therefore be examined in patients who develop unusual neurological findings during the course of this disease and methods of prevention may need to be considered in future studies.
Concomitant radiation therapy and cis‐diamminedichloroplatinum (II) in patients with advanced head and neck cancer
Authors: Creagan Edward T. , Fountain Karen S. , Frytak Stephen , Desanto Lawrence W. , Earle John D. 
Published: February 2007

AbstractThree patients with locally advanced head and neck squamous cell cancer received concomitant radiation therapy (XRT) and cis‐diamminedichloroplatinum (CDDP). The dose of 6,000 rads was to be administered in two 3,000‐rad courses separated by 3 weeks. The CDDP, 30 mg/m2, was to be given intravenously on days 2 and 12 of each half of XRT. We were especially concerned with the occurrence of an abscess in one patient and an abscess with hemorrhage in another. In addition, each patient experienced severe and intractable nausea, vomiting, and a pervasive feeling of ill‐health which seemed out of proportion to that usually observed from either XRT or CDDP alone. If the findings in this pilot study are confirmed, the toxicity of XRT with concurrent CDDP as used in our study may well obviate routine clinical usage.
Religion in patients with advanced cancer
Authors: Yates Jerome W. , Chalmer Bruce J. , James Paul St. , Follansbee Mark , McKegney F. Patrick 
Published: February 2007

AbstractData on religious belief, activity, and connections, and ratings of happiness, life satisfaction, and pain level were obtained periodically from 71 patients with advanced cancer. Religious belief showed substantial positive correlation with life satisfaction, and religious activity and connections were significantly correlated with both happiness and life satisfaction. Religious patients also reported significantly lower levels of pain, even though they were no less likely to report the presence of pain. Data from the 36 patients who have since died show no correlation between the religion variables and duration of survival. In general, the patients showed little change in religious belief over time. Religion seems to be an important source of support for many patients.
Progression of methotrexate‐induced leukoencephalopathy in children with leukemia
Authors: Ch'ien Lawrence T. , Aur Rhomes J. A. , Verzosa Manuel S. , Coburn Thomas P. , Goff John R. , Hustu H. Omar , Price Robert A. , Seifert M. Jane , Simone Joseph V. 
Published: February 2007

AbstractFrom 1972 ‐ 1974, 228 children began treatment for acute lymphocytic leukemia and were prospectively assessed for neurologic complications. After CNS irradiation (2,400 rad) and intrathecal methotrexate (MTX), they received weekly intravenous maintenance therapy with MTX alone (40–60 mg/m2; 20 patients) or MTX (10‐30 mg/m2) with other drugs (208 patients). Signs of leukoencephalopathy appeared in 11 children (nine without CNS leukemia) after 4‐15 months of IV MTX alone, and included lethargy, seizures, spasticity, paresis, drooling, and dementia. Before or during the clinical onset, EEG frequencies slowed (all ten patients tested). Radionuclide scans showed periventricular accumulation of 99mTc (9/11 patients) and remained abnormal for ≥ six months in eight patients. Cranial computed tomograms or neuropathology findings (five patients each) demonstrated leukoencephalopathy (nine patients) and radiation‐related microangiopathy (ten patients). Severe neurologic and neuropsychologic dysfunctions were present in four long‐term survivors.
Cloning of fresh lymphoma cells
Authors: Nishikori Masaru , Hansen Herbert , Yen Andrew , Clarkson Bayard 
Published: February 2007

AbstractWe attempted to induce in vivo clonal growth of neoplastic lymphoid cells from fresh specimens of involved tissue from 22 patients with non‐Hodgkin lymphoma (NHL). Conditioned media derived from two human B‐lymphocyte tissue culture lines were tested for their ability to promote colony growth. In addition, we compared the incidence of colony induction to the flash‐3H‐thymidine labeling index (LI) of the cells in the tissues cultured. Successful colony induction occurred in three‐tenths of the cases of diffuse histiocytic lymphoma and one‐half of the cases of nodular lymphoma. Cloning efficiencies were low, ranging from 0.0003 to 0.04%. There was no apparent relationship between successful instances of cloning and LI. We have confirmed the observations of Jones et al that lymphoid tumor cells can be cloned from tissues involved by NHL using a soft agar system. The possibility of using such systems for clinical predictive assays of chemotherapeutic drug toxicity toward tumor cells of NHL is discussed. We conclude that further refinements of the assays are desirable before they can be applied to widespread clinical use.
Adriamycin, vincristine, dibromodulcitol, and hexamethylmelamine in advanced previously treated breast cancer: An ECOG pilot study
Authors: Taylor Samuel G. , Wolter Janet 
Published: February 2007

AbstractA combination of adriamycin, vincristine, dibromodulcitol, and hexamethylmelamine was piloted in patients with advanced breast cancer who had failed prior CMFP chemotherapy, as a part of ongoing trials by the Eastern Cooperative Oncology Group to improve second‐line chemotherapy for this disease. The vincristine was given as an intensive 5 week induction regimen and hexamethylmelamine was administered on days 15–27 of a 28 day cycle, at the time of anticipated nadir peripheral blood counts. The study was terminated early after only 9 patients had been entered because of severe neurotoxicity related to the intensive schedule of vincristine as well as hematologic and gastrointestinal side effects. Three patients responded for 11, 18 and 21 weeks. The limited therapeutic benefit did not justify the toxicity produced, and suggested that intensive dosage schedules of vincristine, and use of low dose hexamethylmelamine during the time of anticipated hematologic nadir counts would not be of substantial benefit.
Psychological late effects of leukemia in children and their prevention
Authors: Schuler D. , Polcz Alaine , Révész T. , Koó Rozália , Bakos Márta , Gál Nóra 
Published: February 2007

AbstractThe psychological and intellectual sequelae of childhood leukemia and its treatment were examined in 48 children with acute leukemia in long remission. Verbal and performance IQ values were determined in addition to full scale IQ. Performance was worse than the verbal IQ in children who were less than six years old at the time of diagnosis. Cranial irradiation even in repeated doses of 2,400 rads had no effect on these children's intellects. Most of the patients, however, showed severe emotional problems when constructing their “world” from given objects. The frequency and severity of these emotional problems could be much alleviated by regular psychological care.
Cis‐dichlorodiammineplatinum (II) and VP 16–213 combination chemotherapy for non‐small cell lung cancer
Authors: Goldhirsch Aron , Joss Rudolf A. , Cavalli Franco , Sonntag Roland W. , Brunner Kurt W. 
Published: February 2007

AbstractTwenty‐three patients with non‐small cell lung cancer were treated with a combination of cis‐dichlorodiammineplatinum(II) 100 mg/m2 IV on day 1 and VP 16–213 80 mg/m2 IV on days 1–3. Eighteen patients are evaluable for response. Seven partial remissions with a median duration of 3 months (range, 1–13+) have been observed. Three patients exhibit stable disease, and eight patients show tumor progression. Overall survival was 5+ months (range, 1–13+); 7.5 months (range, 3–13+) for responders and 3+ months (range, 1–9+) for non‐responders. Hematologic toxicity was acceptable, but poor subjective tolerance (nausea, vomiting, loss of appetite) was the main factor limiting treatment duration.
5‐fluorouracil and cis‐platinum in the treatment of refractory solid tumors: A pediatric oncology group phase I — II study
Authors: Land Vita J. , Dyment Paul G. , Starling Kenneth , Strandjord Sarah E. , Chan Raphael 
Published: February 2007

AbstractEleven patients with osteogenic sarcoma (9), Hodgkin disease (1), and mesenchymal sarcoma (1), were treated with 5‐fluorouracil (5‐FU) and cisplatin (DDP). Myelosuppression and vomiting of variable degrees occurred in all. No responses were seen.
Primary hemangiosarcoma of the spleen: Report of four cases
Authors: Sordillo Emilia Mia , Sordillo Peter P. , Hajdu Steven I. 
Published: February 2007

AbstractFour cases of primary splenic hemangiosarcoma are described. The most common presenting symptoms were recurrent fever, malaise, and abdominal pain. Three patients also had complaints referable to the urinary tract. Severe hemo‐lytic anemia with bizarre or fragmented red blood cells on peripheral smear was noted in three patients, in two cases, for more than 1 year before diagnosis. Two patients had been treated for mammary carcinoma with ionizing radiation 10 years before developing hemangiosarcoma of the spleen. One patient had multiple congenital hemangiomas present from birth, and is thought to have developed hemangiosarcoma in a previously existing benign hemangi‐oma. None of our patients survived more than 7 months after the diagnosis of hemangiosarcoma. The importance of early detection and treatment of this tumor is discussed.
Histiocytic lymphoma following resolution of sarcoidosis
Authors: Foon Kenneth A. , Filderman Andrew , Gale Robert Peter 
Published: February 2007

AbstractA 32‐year‐old female who developed respiratory symptoms and hilar and mediastinal lymph node enlargement had a biopsy of a mediastinal lymph node typical of sarcoidosis. The symptoms and lymphadenopathy resolved spontaneously without therapy. Eighteen months later the patient developed recurrent respiratory symptoms and a large anterior mediastinal mass, a biopsy of which showed a diffuse sclerosing histiocytic lymphoma, without evidence of sarcoidosis. The possibility of a common etiologic factor or transformation of sarcoidosis into a histiocytic lymphoma are discussed.
Prevention of infection and bleeding in leukemic patients receiving intensive remission maintenance therapy
Authors: Preisler H. D. , Early A. , Hryniuk W. 
Published: February 2007

AbstractLeukemic patients were treated with intensive chemotherapy to reduce the number of leukemic cells remaining after complete remission was induced. This therapy resulted in periods of severe granulocytopenia and thrombocytopenia. Considering 13 patients who did not receive antibacterial prophylaxis, documented infection was quite common including four episodes of bacteremia and three urinary tract infections. By contrast, patients who received co‐trimoxazole as antibacterial prophylaxis experienced one half as many febrile episodes and no serious infections. Prophylactic co‐trimoxazole is beneficial for patients with marrow remission in this study. Similar benefit in patients with leukemic marrows remains to be established. All patients received prophylactic platelet transfusions three times a week when their platelet counts were < 20,000/μl. There were no episodes of bleeding other than petechiae.
Clinical data management and analysis using a microcomputer
Authors: Dodge Richard K. , Krakoff Irwin H. 
Published: February 2007

AbstractIn the clinical setting, it is imperative that the medical staff as well as certain support staff have ready access to patients' records and on‐study data. Computerization of the clinical data must not deter non‐computer‐oriented data users from getting at the information they need. In fact, the computer system should be designed for ease of operation by all potential users so that it becomes a valuable and unobtrusive aid to the clinical environment. This paper describes the workings of a microcomputer system at the Vermont Regional Cancer Center.