bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic treatment of canine osteoarthritis with glycosaminoglycan polysulfuric acid ester
Authors: Altman Roy D. , Dean David D. , Muniz Ofelia E. , Howell David S. 
Published: February 2007

AbstractThe therapeutic effect of glycosaminoglycan polysulfuric acid ester (GAGPS) was studied using the Pond‐Nuki model of canine osteoarthritis. The clinical setting was simulated by permitting 4 weeks ambulation without treatment, following anterior cruciate transection. Animals were then injected with GAGPS, 4 mg/kg intramuscularly, twice weekly during weeks 4–8. Control animals received intramuscular saline. The study was terminated 4 weeks after completion of the GAGPS or saline regimen (i.e., 12 weeks postoperatively). Cartilage from the medial femoral condyle was analyzed for collagen integrity (swelling properties), hydroxyproline, uronic acid, active and total proteoglycan (PG)–degrading metalloproteinase, PG‐degrading serine proteinase, and histopathology (Mankin score). Condylar cartilage from animals treated with GAGPS demonstrated less cartilage swelling, less total and active metalloproteinase, and lower histopathologic scores than were found in cartilage from saline‐treated animals. GAGPS was able to suppress PG‐degrading enzyme activity and maintain a more normal‐appearing cartilage. It is proposed that GAGPS suppressed PG breakdown by decreasing synthesis of metalloproteinase or by directly inhibiting metalloproteinase in cartilage, rather than by increasing synthesis of PG by chondrocytes.
Mental status abnormalities in temporal arteritis: A treatable cause of dementia in the elderly
Authors: Pascuzzi Robert M. , Roos Karen L. , Davis Thomas E. 
Published: February 2007

AbstractAlthough temporal arteritis (TA) is a common vasculitis, mental status changes and higher cortical dysfunction have received limited attention in the literature. We report a case which illustrates the potential for TA to produce chronic fluctuating delirium, delusional thinking, and memory impairment in the absence of concomitant symptoms of headache and visual loss. In addition, TA may produce differing symptoms at different times in the same patient.
Inflammatory microcrystals stimulate interleukin‐6 production and secretion by human monocytes and synoviocytes
Authors: Guerne Pierre‐André , Terkeltaub Robert , Zuraw Bruce , Lotz Martin 
Published: February 2007

AbstractCrystal‐related joint diseases are often associated with systemic inflammatory manifestations, including increased levels of acute‐phase proteins, leukocytosis, and fever. Recently, interleukin‐6 (IL‐6) has been identified as a pluripotent mediator of inflammatory and immunologic responses and the major hepatocyte‐stimulating factor. In this study, we demonstrated that monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals, and to a lesser extent, hydroxyapatite crystals, increased IL‐6 production by synoviocytes and monocytes in vitro. Immunoprecipitation experiments showed that MSU and CPPD crystals, but not hydroxyapatite crystals, were able to increase the release of newly synthesized IL‐6. Crystal‐induced IL‐6 stimulated acute‐phase protein synthesis, immunoglobulin production, and hybridoma cell proliferation, which was neutralized by a specific antibody to IL‐6. High levels of IL‐6 were found in synovial fluid from patients with gout and pseudogout. These results demonstrate that MSU and CPPD crystals can induce IL‐6 production in synoviocytes and monocytes, and that synovial fluid from patients with gout and pseudogout contains high levels of IL‐6. Crystal‐induced IL‐6 is likely to be an important mediator of inflammatory responses in acute gout and pseudogout.
Solitary plasmacytoma of the skull revealed by a mononeuritis multiplex associated with immune complex vasculitis
Authors: Gherardi Romain K. , Martin‐Mondiere Claude , Amiel HÉLÈNe , Viard Jean‐Paul , Salama Jeffrey , Delaporte Pierre 
Published: February 2007

AbstractWe describe a patient with a solitary plasmacytoma of the skull, in whom mononeuritis multiplex was the presenting manifestation. Some features of the POEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal [M] protein, skin changes), including thrombocytosis, were found. Muscle and nerve biopsies disclosed a small vessel hypersensitivity‐type vasculitis and complement‐fixing immune complex deposits in vessel walls. Removal of the plasmacytoma resulted in clinical improvement and clearance of the vasculitis and immune complex deposits.
Hereditary amyloidosis: Evidence against early amyloid deposition
Authors: Harats Noam , Worth Robert M. , Benson Merrill D. 
Published: February 2007

AbstractTwelve members of the Indiana hereditary amyloidosis type II kindred were tested for the presence of amyloid deposits. All were young adults (age 26–37), with no evidence of disease and with 1 affected parent. Six were found to be carriers of the variant gene, by DNA testing and/or reduced serum retinol‐binding protein levels. Nevertheless, no amyloid could be found in any skin, rectal, or carpal tunnel biopsy specimens. Our results suggest that hereditary amyloidosis type II is a true late‐onset disease, in which accumulation of amyloid does not start until late in life—perhaps only a short time before symptoms appear.
Purification and characterization of Ki antigen and detection of anti‐Ki antibody by enzyme‐linked immunosorbent assay in patients with systemic lupus erythematosus
Authors: Sakamoto Mitsutaka , Takasaki Yoshinari , Yamanaka K. , Kodama A. , Hashimoto H. , Hirose S. 
Published: February 2007

AbstractKi antigen from rabbit thymus extract was purified by ammonium sulfate precipitation, anti‐Ki affinity chromatography, and high pressure liquid chromatography gel filtration. The purified Ki antigen gave a single polypeptide with an MW of 32,000 by sodium dodecyl sulfate–polyacrylamide gel electrophoresis, and it specifically reacted with anti‐Ki antibody by immunoblotting. The isoelectric point of the Ki antigen was found by isoelectric focusing to be 4.3. An enzyme‐linked immunosorbent assay using the purified Ki antigen was established, and the clinical significance of the anti‐Ki antibody in systemic lupus erythematosus (SLE) was studied. Thirty of 140 patients with SLE (21.4%) had anti‐Ki antibody by enzyme‐linked immunosorbent assay, whereas 11 (7.9%) were positive by double immunodiffusion. Analysis of clinical and serologic data on patients with SLE suggested a higher prevalence of central nervous system involvement in patients with anti‐Ki antibody.
Articular cartilage: What it is, why it fails in osteoarthritis, and what can be done about it
Authors: Ghosh Peter 
Published: February 2007

AbstractArticular cartilage covers the ends of long bones and together with synovial fluid is responsible for the remarkably efficient mechanical properties of synovial joints. In osteoarthritis (OA) joint articular cartilage fails. While the etiology of cartilage failure in OA is still controversial, some of the mechanisms responsible for loss of proteoglycans from these tissues have been identified and offer insights for potential avenues of therapeutic control. Many non‐steroidal antiinflammatory drugs (NSAIDs), although effective at suppressing the symptoms of OA, do little to support the attempts by chondrocytes to replenish proteoglycan loss from the extracellular matrix. However, evidence is now accumulating, largely from studies using animal models, that not all antiarthritic agents are deleterious to cartilage. Some may even promote those anabolic processes necessary for its repair and restoration of function. These recent developments offer a more optimistic approach for the therapeutic management of the osteoarthritic patient in the future.
The effects of fatigue, distractibility, and absenteeism on school achievement in children with rheumatic diseases
Authors: Stoff Elizabeth , Bacon Melanie C. , White Patience H. 
Published: February 2007

AbstractChildren with chronic health impairments have a variety of psychosocial, physical, and medical complications affecting daily life. This study investigated the relationship between the effects of a rheumatic disease (RD) and school functioning. Factors investigated were fatigue, distractibility, and absenteeism. In addition, disease severity and mobility were assessed. Forty‐six children with RD and their parents participated in the study. Results indicated that inattention and distractibility were highly related to school achievement. A minimal relationship between fatigue and absenteeism and school performance was noted. In addition, ratings of mobility used by physicians were unrelated to success on math and reading achievement testing.
Applicability of a health status model to osteoarthritis
Authors: Mason John H. , Anderson Jennifer J. , Meenan Robert F. 
Published: February 2007

AbstractA five‐component model of health status has been operationalized by the Arthritis Impact Measurement Scales (AIMS) to serve as a core for the health status assessment of individuals with rheumatoid arthritis (RA). These five components of health status are Lower Extremity Function, Upper Extremity Function, Affect, Symptom, and Social Interaction. To test the utility of this model, this study examines the stability and the applicability of the five‐component model in a different rheumatic disease, osteoarthritis (OA). The model displays similar characteristics between OA and RA for Upper Extremity Function, Affect, and Social Interaction. Pain, however, appears to be more strongly associated with Physical Activity in the OA sample, suggesting that pain as a measured symptom of OA is closely related to ambulation, while pain as a symptom of RA may be more a manifestation of joint involvement and less dependent upon walking and climbing. This study presents the AIMS as a means of assessing five components of health status in either OA or RA.
Adherence and its management in clinical trials: Implications for arthritis treatment trials
Authors: Probstfield Jeffrey L. 
Published: February 2007

AbstractAdherence in clinical trials is a consistent problem regardless of the disease process or organ system under investigation. In this paper data and examples from clinical trials examining cardiovascular diseases are used as the basis for a review of various adherence principles. Issues reviewed include: the importance of adherence in clinical trials, an overall program /or adherence in clinical trials, and specific issues in adherence from arthritis clinical trials. Special attention is given to a program for the prevention of reduced adherence for participants of a clinical trial as well as acute and chronic intervention plans for those with good adherence and those with reduced adherence in a clinical trial.
Natural history and treatment decisions in rheumatoid arthritis revisited
Authors: Weisman Michael H. 
Published: February 2007

AbstractCompliance with RA therapeutic intervention must be viewed within the context of the natural history of the disease with or without drug treatment. Published studies from the 30s to the 80s provide a grim picture: both premature death and marked functional morbidity occur even in population‐based analyses. Intervention with drugs appears to have short‐term gains with little impact beyond 2 years. The reasons for this apparent paradox are two‐fold. (I) OUT drugs are not as successful as we would like; and (2) clinical trials and long‐term outcome studies exaggerate their differences from each other by selection criteria and other methodologic issues. Nevertheless, the picture that is emerging for the 90s is revolutionary. Patients with the worst prognosis are being treated more aggressively earlier in their course, and those that have a favorable prognosis do well without aggressive management and are treated differently. Traditional outcome measures are giving way to others that are more realistic and patient‐oriented. The assumption that more (not less) treatment will remedy the situation is being tested. The impact of the success of Methotrexate on this change in philosophy should not be underestimated.
Expression of caveolin‐3 in the fibroblast‐like type B synoviocytes in the rat temporomandibular joint
Authors: Nozawa‐Inoue Kayoko , Suzuki Akiko , Niwano Masahiro , Kawano Yoshiro , Maeda Takeyasu 
Published: February 2007

AbstractThe present study revealed that the fibroblast‐like type B synoviocytes (covering the surface of the synovial membrane in the rat temporomandibular joint) had muscle‐specific caveolin‐3 protein in their caveolae. The existence of two kinds of type B synoviocytes (with and without caveolin‐3‐immunoreactions even in the synovial lining layer) might reflect the functional difference between them. Anat Rec, 2007. © 2007 Wiley‐Liss, Inc.
Sensitization of the skeleton to vitamin‐A overdosage by cortisol
Authors: Selye Hans 
Published: February 2007

AbstractThe simultaneous administration of cortisol and vitamin A to albino rats resulted in intense bone absorption not observed with vitamin A alone. The action of glucocorticoids was shown to be the opposite of the action of somatotropic hormones in respect to injury resulting from hypervitaminosis A.Le administration simultanee de cortisol e vitamina A a rattos albin resultava in intense absorption ossee non observate post vitamina A sol. Esseva monstrate que le action de glucocorticoides es le opposite del action de hormones somatotropic con respecto a insultos resultante de hypervitaminosis per vitamina A.
Chromatographic and electrophoretic studies of the L.E. factor
Authors: Fallet Georges H. , Lospalluto Joseph , Ziff Morris 
Published: February 2007

AbstractIn fractionation studies of L.E. sera using chromatographic separation and zone electrophoresis the L.E. factor was confined to a gamma globulin component. L.E. factor could be separated from rheumatoid factor. Difference in molecular size of these two factors is suggested by an ultracentrifugation experiment.
Hemagglutination study of serum factors related to L.E. cell formation
Authors: Lee Ronald C. , Epstein Wallace V. 
Published: February 2007

AbstractLupus factor as detected by tannic acidtreated sheep erythrocytes coated with a saline extract of nucleoprotein was found in the sera of 10 patients with systemic lupus erythrematosus and positive L.E. cell preparations. Nucleoprotein and the nucleoprotein extract (NP‐E) were capable of inhibiting the NP‐E hemagglutination as well as L.E. cell formation. Gamma globulin and DNA were not capable of inhibiting the NP‐E hemagglutination test.
Dexamethasone: Antirheumatic properties, hormonal effects and adverse reactions (A 16 month study)
Authors: Black Roger L. , Reefe William E. , David John R. , Bloch Kurt J. , Ehrlich George E. , Bunim Joseph J. 
Published: February 2007

AbstractDexamethasone has been administered for 8 to 16 months (0.5 to 4.0 mg. daily), with satisfactory antirheumatic response in 20 of 27 patients with rheumatoid arthritis.This compound has been found to be the most potent anti‐inflammatory corticosteroid thus far produced. It suppresses ACTH and possibly thyroid‐stimulating hormone production by the anterior pituitary. Thyroid function, as measured by radioactive iodine uptake, was reduced in 11 of 19 patients during dexamethasone administration.The most common side effect in this group was striking weight gain—more than 4 Kg. in 19 patients. Three patients experienced pathologic fractures and one, a peptic ulcer during dexamethasone therapy. There were two deaths during the period of study.
Experimental hemarthrosis: The removal of chromium‐51‐ and iron‐59‐labeled erythrocytes injected into the knee joint of rabbit and man
Authors: Rodnan Gerald P. 
Published: February 2007

AbstractThe clearance of Cr51‐ and Fe59‐labeled erythrocytes from the knee joint is delayed by immobilization of the limb, but is not significantly affected by repeated antecedent hemarthrosis, or the injection of hyaluronidase or hydrocortisone.
Clinical, metabolic and endocrinologic effects of abrupt cessation of maintenance cortisone acetate therapy in rheumatoid arthritis
Authors: Calkins Evan , Engel Lewis L. , Mitchell Donald M. , Carter Priscilla , Bauer Walter 
Published: February 2007

AbstractThree patients with rheumatoid arthritis who had been maintained on cortisone treatment for periods of at least two and one‐half years, were subjected to detailed clinical and metabolic study immediately prior to and following abrupt cessation of cortisone therapy. Clinical manifestations resembling adrenal insufficiency could be differentiated from those of active rheumatoid arthritis. The latter were accompanied by striking sodium retention and evidences of increased plasma volume. Although the symptoms of adrenal insufficiency disappeared four days after stopping cortisone, steroid excretion studies indicated that reduced and abnormal adrenal cortical function persisted for a longer period than this and suggested that this could not entirely be attributed to a failure of pituitary response.
Immunization to experimental arthritis in rats
Authors: Hershberger L. G. , Hansen L. M. , Calhoun D. W. 
Published: February 2007

AbstractProtection against experimental arthritis followed various pretreatments that appeared to elicit production of antibodies to the arthritogenic agent. Passive immunity to arthritis was produced by injecting serum from rats or rabbits immunized against exudate containing the arthritogenic factor. The nature of the arthritogenic agent is discussed.
An attempt to produce systemic lupus erythematosus and rheumatoid arthritis by crude desoxyribosenucleic acid and joint antigens
Authors: Dubois Edmund L. , Katz Yale J 
Published: February 2007

AbstractAlbino rabbits and dogs received injections of heterologous, homologous and autologous antigens both with and without Freund adjuvant. The animals were studied as long as 17 months. Thirteen rabbits received crude calf thymus. Four rabbits were given homologous bone and joint suspension. Three dogs were injected with saline emulsions of their own tail bone and cartilage. There was no clinical or laboratory evidence of anti‐desoxyribosenucleic acid antibodies, systemic lupus erythematosus or rheumatoid arthritis.
Physiologic disposition and uricosuric effect of a keto analog of oxyphenhutazone (G.29701)
Authors: Seegmiller J. E. , Dayton P. G. , Burns J. J. 
Published: February 2007

AbstractThe alteration in pharmacologic action attending the introduction of a keto group into the side chain of oxyphenbutazone to form keto‐oxyphenbutazone (G‐29701) include loss of antirheumatic and sodium retaining properties of the parent compound and appearance of uricosuric action correlated with the much greater acidity of the molecule (pKa 2.3). Comparison with sulfinpyrazone (Anturan) or zoxazolamine (Flexin) shows G‐29701 to have a comparable unicosuric potency witb a significantly longer half life of 8 hours.
The diagnosis and therapy of acute suppurative arthritis
Authors: Ward John , Cohen Alan S. , Bauer Walter 
Published: February 2007

AbstractAcute suppurative arthritis is a form of joint disease demanding prompt diagnosis and therapy. Twenty‐four cases are reviewed, and it is suggested that in addition to clinical findings, analysis of synovial fluid is essential. Synovial leukocyte count greater than 50,000 cells per cu. mm., with 90 per cent or more polymorphonuclear leukocytes and a synovial fluid‐blood sugar difference of over 40 mg. per cent all support the diagnosis. Adequate treatment consists of early therapy with systemic antibacterial agents, repeated needle aspiration of the joint and appropriate physiotherapy.
Intradermal hypersensitivity in systemic lupus erythematosus
Authors: Bennett J. Claude , Holley Howard L. 
Published: February 2007

AbstractThis is a report of a study of intradermal hypersensitivity to normal leukocytes in patients with systemic lupus erythematosus (SLE). Positive reactions, characterized by induration, edema, and erythema, developed in 15 of 17 SLE patients. This reaction was maximum at 24 hours postinjection. Similar phenomena were rarely observed in control patients. Histological studies of the reaction site revealed evidence of both Arthus and delayed type hypersensitivity.
An Immunoelectrophoretic analysis of antigens reacting with lupus serum
Authors: Atchley William A. 
Published: February 2007

AbstractThe serum of patients with systemic lupus erythematosus may contain antibodies reacting in a variety of ways against several intracellular antigens. This report describes a new method of analyzing these antigen‐antibody reactions by immunoelectrophoresis on cellulose acetate membranes. The results show that abnormal sera may contain at least two different precipitating antibodies, one directed against a deoxy‐ribonucleohistone complex, and the other directed against an antigen that may be histone not attached to DNA.
A fluorescent test for the rheumatoid factor in blood
Authors: Hess Evelyn , Ziff Morris 
Published: February 2007

AbstractA fluorescent test for the rheumatoid factor is described in which the buffy coat of blood is separated and treated with fluoresceinated aggregated F‐II of human gamma globulin. Fluorescence of the suspended leukocytes and platelets indicates the presence of the factor coated on the cell surfaces. Ninety per cent of patients with adult rheumatoid arthritis and 76 per cent with juvenile rheumatoid arthritis gave positive tests.
Vitallium mold arthroplasty of the hip in rheumatoid arthritis
Authors: Solomon L. , Aufranc Otto E. 
Published: February 2007

AbstractA critical evaluation is presented of the place of Vitallium mold arthroplasty in rheumatoid arthritis hips. The indications for surgery are reviewed, including mainly the following: 1. Surgery for pain; 2. Surgery for correction of deformity; 3. Surgery for the restoration of motion; 4. Surgery for the preservation of motion. The surgery of the hip in rheumatoid arthritis is presented as au incident in the total management of the patient with this disease. The complications and result of the surgery were evaluated by Dr. Solomon who had nothing to do with the surgery or the choice of patients. This we believe presents an unbiased opinion of the present status of mold arthroplasty.
Corticosteroid therapy of rheumatoid arthritis supplemented with methandrostenolone
Authors: Clark Glenn M. , Mills David 
Published: February 2007

AbstractOur clinical experiences using methandrostenolone (Dianabol) as a supplement to corticosteroid for rheumatoid arthritis have been presented. A group of steroid intoxicated patients tolerated a reduction in corticosteroid dose, showed less hypercorticism and yet maintained their functional capacity. Another group of stable, moderate dosage, clinic patients were followed with Lansbury's systemic index. These patients had a lower Lansbury index (less inflammation) and lower corticosteroid doses following the addition of methandrostenolone.
Capillary circulation in the joint capsule of the rabbit's knee: A vital microscopic study
Authors: Lindstrom Jörgen , Branemark Per‐Ingvar 
Published: February 2007

AbstractThe function of a joint is closely connected to the structure and function of the capillaries in the synovial membrane of the joint capsule. Direct microscopic observation in vivo of the vascular bed of the synovial membrane in the rabbit's knee joint appears to be a suitable technic for analysis of the microcirculation of this membrane. Shunt and sphincter mechanisms are clearly recognizable by this method.
A variant L.E. cell factor reactive only with “altered” nuclear material
Authors: Svec Kathryn H. , Kaplan Melvin H. 
Published: February 2007

AbstractAn unusual antinuclear factor is described in a lupus erythematosus serum which shows L.E. cell activity. The serum was non‐reactive with nuclei of intact cells and with thymus nucleoprotein but demonstrated reactivity with leukocyte nuclei altered by mechanical trauma. It is suggested that this antinuclear factor is related to the L.E. cell activity of the serum and represents a second type of L.E. cell factor.