bluuebunny/crossref_metadata_2025_split huggingface dataset:
A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics
Authors: Vega-Zuniga Tomas , Sumser Anton , Symonova Olga , Koppensteiner Peter , Schmidt Florian H. , Joesch Maximilian 
Published: February 2025

Abstract
For accurate perception and motor control, an animal must distinguish between sensory experiences elicited by external stimuli and those elicited by its own actions. The diversity of behaviors and their complex influences on the senses make this distinction challenging. Here, we uncover an action–cue hub that coordinates motor commands with visual processing in the brain’s first visual relay. We show that the ventral lateral geniculate nucleus (vLGN) acts as a corollary discharge center, integrating visual translational optic flow signals with motor copies from saccades, locomotion and pupil dynamics. The vLGN relays these signals to correct action-specific visual distortions and to refine perception, as shown for the superior colliculus and in a depth-estimation task. Simultaneously, brain-wide vLGN projections drive corrective actions necessary for accurate visuomotor control. Our results reveal an extended corollary discharge architecture that refines early visual transformations and coordinates actions via a distributed hub-and-spoke network to enable visual perception during action.
Anti-colorectal cancer activity of constructed oleogels based on encapsulated bioactive canola extract in lecithin for edible semisolid applications
Authors: Akl Engy M. , Abd-Rabou Ahmed A. , Hashim Ayat F. 
Published: February 2025

Abstract
Globally, colorectal cancer ranks second in women and third in men. Hydrophilic anticancer agents have limited use in lipid systems due to their weak solubility. Therefore, this study aimed to develop oleogels based on pumpkin seed oil (R1) and hydrophilic bioactive canola extract (BCE or R2) that were extracted from canola meal by-products. BCE was effectively dispersed in oleogels through the encapsulation of BCE with various concentrations (0.08, 0.2, and 0.4%) in soy lecithin to form BCE gelling agents. Four formulations (F1 as plain, F2-F4 with different concentrations of BCE) were produced using two gelators (BCE gelling agent and beeswax). The oxidative stability, microstructure, FTIR, antioxidant activity, and time-dependent experiment were investigated. The cytotoxicity against colorectal HCT116 and Caco-2 cancer cell lines in vitro was evaluated. The anti-apoptotic PI3k and COX-2 protein expressions were also assessed. The peroxide, p-anisidine, and total oxidation values of F4 were 7.85, 26.66, and 42.35, respectively, during 60 days at 60 ± 2 °C. The antioxidant activity values of F4 were 74.40% for DPPH, 54.28% for ABTS, and 5.77 mg/g for FRAP. F4 demonstrated the highest significant cytotoxic effects on cancerous cells, particularly in the Caco-2 cells with 1.40- and 1.41-fold increases compared to R2 and the positive control doxorubicin, respectively. PI3k and COX-2 expression levels were down-regulated while iNOS activity was up-regulated in both cells, with very high down-regulation recorded for F4 in Caco-2 cells. This study developed a method for producing stable lipid products loaded with hydrophilic antioxidants that may be used as an anti-colorectal platform.
Associations between depression and nature-based recreation: A cross-sectional study of adults in the United States, Spain, and Brazil
Authors: Rosa Claudio D. , Larson Lincoln R. , Collado Silvia , Geiger Sandra J. , Profice Christiana C. , Menuchi Marcos R. T. P. 
Published: February 2025

Abstract
Cumulating evidence suggests that nature-based interventions may alleviate depression, but the association between engagement in nature-based activities and specific depressive symptoms remains unknown. We conducted a cross-sectional study to investigate how Major Depressive Disorder (MDD) symptom criteria relate to engagement in nature-based recreation (any nature-based activities, forest-based activities, gardening, nature-based adventure activities) among American (n = 606), Spanish (n = 438), and Brazilian (n = 448) adults (≥ 18 years old). People who reported engaging in any nature-based activities at least once per month reported experiencing all nine symptom criteria for MDD (e.g., anhedonia, feeling depressed or hopeless, sleep problems, trouble concentrating, and suicidal ideation) at lower rates than those who did not participate in nature-based recreation as frequently. Results were relatively consistent across countries and types of nature-based activities, suggesting that many forms of nature-based recreation are negatively correlated with the nine symptom criteria for MDD. The associations tended to be weaker overall among Spanish respondents. Nature-based recreation appeared to have a stronger inverse relationship with suicidal ideation than with other depressive symptoms. The cross-sectional design of this study limits the causal interpretation of the observed associations. If future experimental studies confirm our findings, practitioners across different countries can consider recommending participation in nature-based recreation to alleviate their clients’ MDD symptoms.
Exploring the physical properties of the new MoX6 (X = Cl or Br) materials
Authors: Jabar A. , Maaouni N. , Benyoussef S. , Bahmad L. 
Published: February 2025

A comprehensive study of mechanical, electronic, optical, and thermodynamic properties of MoX6 (X = Cl or Br), has been presented, within the Wien2k framework, based on the full-potential linearized augmented plane wave (FPLAPW) method.
Aktuelle Analyse der Zusatzweiterbildung Tropenmedizin
Authors: Eggers Yannik , Möller Tina , Wendt Sebastian , Kreuels Benno , Fröschl Günter , Köhler Carsten , Bélard Sabine , Schneitler Sophie 
Published: February 2025

ZUSAMMENFASSUNGAufgrund des Bedarfs an Tropenmedizinern in Deutschland wurde 2018 die Musterweiterbildungsordnung der Bundesärztekammer geändert. Ziel dieser Studie ist, die Auswirkungen dieser Änderungen sowie die aktuellen Herausforderungen der Zusatzweiterbildung Tropenmedizin zu untersuchen. Drei Onlineumfragen wurden unter Mitgliedern der DTG sowie Absolventen der Diplomkurse Tropenmedizin durchgeführt, ergänzt durch eine Analyse von Daten der Bundesärztekammer und verfügbaren Weiterbildungsstellen. Trotz großen Interesses bleibt die Anzahl an Ärzten mit Zusatzweiterbildung Tropenmedizin gering. Hürden sind der Mangel an Weiterbildungsstellen und fehlende Kenntnis der neuen Regelungen. Zusätzlich zu Änderungen der Weiterbildungsordnung sind deren aktive Bewerbung und eine Erhöhung der Weiterbildungsplätze entscheidend, um die Anzahl der Tropenmediziner zu erhöhen.
Inflammatory Choroidal Neovascularization in Pediatric Uveitis: A Case Series
Authors: Gauderon Amandine , Eandi Chiara , Koryllou Aikaterini , Hoogewoud Florence , Theodoropoulou Katerina , Guex-Crosier Yan 
Published: February 2025

Abstract
Background The aim of our study is to describe clinical features, therapy, and outcome of children with inflammatory choroidal neovascularization (CNV).
Methods Retrospective case series of children seen at the Jules-Gonin Eye Hospital between 2000 and 2024 with macular choroidal neovascularisation secondary to ocular inflammation.
Results Four children (one male, three females) developed a retro-foveolar neovascular membrane after a median time of 2.5 months (range 1 – 16 months) following uveitis onset. The median age at presentation was 12 years (range 5 – 12 years). The CNV presentation was unilateral in all four cases, with three patients having posterior uveitis and one panuveitis. Two patients had idiopathic bilateral granulomatous uveitis while the other two had suspected toxoplasmosis chorioretinitis. Idiopathic cases were treated with oral steroids, with one patient being additionally treated with adalimumab. Toxoplasmosis cases were managed with antibiotics and oral steroids. CNV treatment involved a single anti-VEGF injection in two cases, six injections in one case, and no injection in one case due to CNV inactivity. Median follow-up period was 4.25 years (range 0.75 to 11 years) and the median final best-corrected visual acuity was 0.9 (range 0.6 – 1.25). No recurrence of CNV was
observed, despite uveitis reactivation in two cases.
Conclusion Anti-VEGF therapy is safe even in young children with minimal injections required to control the disease. Treating the underlying cause of uveitis with appropriate therapy is also crucial.
Morphology of Retinal Hemangioblastoma in von Hippel-Lindau Disease Revealed by Optical Coherence Tomography Angiography
Authors: Laich Yannik , Lang Stefan J. , Glatz Andreas , Farassat Navid , Bucher Felicitas , Nuessle Simone , Böhringer Daniel , Lagrèze Wolf Alexander , Sideris Spyridon , Maloca Peter , Lange Clemens , Reinhard Thomas , Agostini Hansjürgen , Reich Michael 
Published: February 2025

Abstract
Background To characterize different growth patterns of retinal hemangioblastomas (RHs) in patients with von Hippel-Lindau disease (VHLD) using swept-source optical coherence tomography angiography (SS-OCTA).
Methods Single-center observational cross-sectional study. SS-OCTA B-scans were centered over primary treatment-naïve RHs to display the perfusion in the inner, middle, and outer areas (IA, MA, OA). Distinctive growth patterns were characterized using K-means cluster analysis of the flow signal.
Results Annual screening of 201 patients with VHLD revealed 49 patients with 85 RHs (41 recurrent, 44 primary treatment-naïve RHs). High-quality SS-OCTA images were available for 24 primary RHs and were pooled with scans of the treatment-naïve form of 6 recurrent RHs, which were taken at a prior visit, for further analysis. Out of 30 primary RHs, 18 were located juxtapapillary (jRH) and 12 peripherally (pRH). K-means cluster analysis distinguished seven exophytic (23.3%, 2 jRH, 5 pRH), nine endophytic (30%, 6 jRH, 3 pRH), and fourteen sessile (46.7%, 10 jRH, 4 pRH) growth patterns. Fractions of the flow signal in the IA, MA, and OA were 7.3 ± 3.3%, 89.3 ± 5.0%, and 3.4 ± 3.5% for exophytic RHs, 22.2 ± 7.4%, 65.6 ± 7.3%, and 12.1 ± 8.2% for sessile RHs, and 65.4 ± 5.7%, 26.6 ± 4.9%, and 8.0 ± 6.1% for endophytic RH.
Conclusion OCTA contributes to further elucidating the morphology of RHs as a useful complementary diagnostic tool that can help to provide customized therapeutic approaches in the future and thus improve the effectiveness of RH treatment.
Synthesis of the Tetrasaccharide Repeating Unit Corresponding to the O-Antigen of Providencia alcalifaciens O7:H7 Strain
Authors: Misra Anup Kumar , Rana Abhijit 
Published: February 2025

AbstractSynthesis of the tetrasaccharide corresponding to the O-antigen of Providencia alcalifaciens O7:H7 strain was achieved in satisfactory yield by applying a stereoselective glycosylation strategy. Stereoselective incorporation of β-l-rhamnose, α-d-glucosamine and α-d-glucose moieties in the tetrasaccharide was achieved in very good yield. The d-glucuronic acid moiety in the tetrasaccharide was achieved by late-stage TEMPO–bis(acetoxy)iodobenzene (BAIB)-mediated regioselective oxidation of the primary hydroxyl group of the d-glucose moiety. Thioglycosides were used as glycosyl donors in the presence of a combination of N-iodosuccinimide (NIS) and triflic acid (TfOH) as thiophilic promoter.
Wir haben die Wahl
Authors: Pintarelli-Rauschenbach Manuela 
Published: February 2025

ZusammenfassungDas Jahr ist erst wenige Wochen alt und schon stehen wichtige Entscheidungen an. Etwas früher als geplant
wählen wir am 23. Februar einen neuen Bundestag. Das heißt auch: In der Gesundheitspolitik kann sich
alles und nichts ändern. Wer wird der zukünftige oder die zukünftige Gesundheitsminister*in? Wer gibt die
Richtung in der Gesundheitspolitik in den nächsten Jahren vor? Wie positionieren sich die Parteien zur
Physiotherapie und wird die dringend benötigte Berufsreform endlich umgesetzt? Wir haben uns mit diesen
Fragen intensiv beschäftigt und Forderungen für eine Weiterentwicklung der Physiotherapie
formuliert (► Seite 10). Wir setzen uns für bessere Rahmenbedingungen ein und werden nicht müde,
die weitere Entwicklung unseres schönen Berufs voranzutreiben. Am Tag der Bundestagswahl zählt unsere
Stimme. Wir haben die Wahl!
Min-max method involving double phase Kirchhoff problems with variable exponents
Authors: Chniba Riheb , Benali Khaled , Ouerghi Haikel 
Published: February 2025

In this paper, we prove the existence of solutions for double phase Kirchhoff problems with variable exponents. More precisely, we use the min-max method and the variational approach in order to prove the existence of weak nontrivial solutions for such problem.
Cognitive analysis of gas pipeline discourse
Authors: Frayne Craig 
Published: February 2025

Abstract
This paper uses cognitive discourse analysis to investigate whether differing cognitive structures and mental
representations are reflected in sides of pipeline debates. Quotations were extracted from a web corpus to assign statements to
identifiable actors in two pipeline protests: the Dakota Access Pipeline (DAP) and Coastal GasLink Pipeline (CGP). Statements were
then grouped according to the stance of the speakers. Aspects of cognitive orientation, depth, and constructiveness were compared
between the groups. Results demonstrate methods and approaches that could be adapted to place-based conflicts between communities
and industries. The analysis obtains insights which could advance linguistic scholarship related to natural resources and the
environment as well as enhance conceptual clarity and mutual understanding in the context of specific projects or debates.
Secondary electron emission model for X-Ray induced photoelectric emission from semiconductors and insulators and the calculation of X-Ray attenuation cross sections
Authors: Zhuang Zhong , Xie Aigen , Xu Yi-Kang 
Published: February 2025

Abstract
Secondary electron emission SEE model for 0.1-10 keV X-Ray induced photoelectric emission PE from semiconductors and insulators SI was developed here. From the SEE model for X-Ray induced PE from SI developed here, theories of thermal emission and the characteristics of electron induced SEE and X-Ray induced PE, the methods of obtaining BPE, the mean escape depth of 0.1-10 keV X-Ray induced true secondary electrons λPE from SI and ɛPE were presented, respectively; BPE denotes the mean probability that an internal true secondary electron, which is excited by X-Ray, escapes into vacuum upon reaching emission surface of SI; ɛPE denotes the average energy required to produce a true secondary electron in SI by X-Ray. Based on parameters of vacuum evaporated alkali halides, existing theories of propagate of secondary electrons from SI and theories developed here, the universal formula for λPE of vacuum evaporated alkali halides in photon energy range of 0.1-10 keV was obtained, and the methods of calculating the spectra of X-Ray induced true secondary electrons, X-Ray attenuation cross sections and X-Ray penetration depth were presented, respectively. &#xD;Index terms: X-Ray, photoelectric emission from semiconductors and insulators, X-Ray attenuation cross sections, X-Ray penetration depth, secondary electron emission.
Osmotically-induced rupture of viral capsids
Authors: Aguiar Felipe , Colla Thiago 
Published: February 2025

Abstract
A simple model is proposed aimed to investigate how the amount of dissociated ions influences the mechanical stability of viral capsids. After an osmotic and mechanical equilibrium is established with the outer solution, a non-adiabatic change in salt concentration at the external environment is considered, which results in a significant solvent inflow across the capsid surface, eventually leading to its rupture. The key assumption behind such an osmotic shock mechanism is that solvent flow takes place at timescales much shorter than the ones typical of ionic diffusion. In order to theoretically describe this effect, we herein propose a thermodynamic model based on the traditional Flory theory. The proposed approach is further combined with a continuum Hookian elastic model of surface stretching and pore-opening along the lines of a classical nucleation theory, allowing us to establish the conditions under which capsid mechanical instability takes place. Despite its non-local character, the proposed model is able to capture most of the relevant physical mechanisms controlling capsid stability, namely the volume exclusion and entropy of mixing effects among the densely-packed components, the elastic cost for capsid stretching and further pore opening, the Donnan equilibrium across the interface, as well as the large entropy loss resulting from folding the viral genome into close-packed configurations inside the capsid. It is shown that, depending on the particular combination of initial condition and capsid surface strength, the capsid can either become unstable after removal of a prescribed amount of external salt, or be fully stable against osmotic shock, regardless of the amount of ionic dilution.
Effect of tensile stress on the magnetic Barkhausen noise near grain boundary in grain-oriented silicon steel: experimental observation
Authors: Zhu Kongyang , Zhang Shurui , Li Peng , He Cunfu , Liu Xiucheng 
Published: February 2025

Abstract
Due to the spatial resolution limitation of the magnetic Barkhausen Noise (MBN) sensor, the mechanism by which MBN signals are affected by the elastoplastic evolution process at the grain scale remains unclear. In this study, a high-resolution MBN sensor was used to investigate the distribution of MBN signals near grain boundary in grain-oriented silicon steel under controlled residual plastic strain and applied stress, simulating a cold work hardening process. It was observed that MBN signals near the grain boundary varied with the introduction of applied stress and residual plastic strain. A multi-factor mechanism was analyzed and proposed, incorporating the effects of microstructure, applied stress/strain, and residual stress at the grain scale. These findings provide valuable insights for the subsequent improvement of the micromagnetic theory at the grain scale.
Analyzing Point Liquid Loading Effects on Transversely Isotropic Poroelastic Media using Green's Function
Authors: Tariq Muzammal Hameed , Zhou Yue-Ting 
Published: February 2025

Abstract
Understanding the effects of point liquid loading on transversely isotropic poroelastic media is crucial for advancing geomechanics and biomechanics, where precise modeling of fluid-structure interactions is essential. This paper presents a comprehensive analysis of infinite transversely isotropic poroelasticity under a fluid source, based on Biot's theory, aiming to uncover new and previously unexplored insights in the literature. We begin our study by deriving a general solution for fluid-saturated, transversely isotropic poroelastic materials in terms of harmonic functions that satisfy sixth-order homogeneous partial differential equations, using potential theory and Almansi's theorem. Based on these general solutions and potential functions, we construct a Green's function for a point fluid source, introducing three new harmonic functions with undetermined constants. These constants are determined by enforcing continuity and equilibrium conditions. Substituting these into the general solution yields fundamental solutions for poroelasticity that provide crucial support for a wide range of project problems. Numerical results and comparisons with existing literature are provided to illustrate physical mechanisms through contour plots. Our observations reveal that all components tend to zero in the far field and become singular at the concentrated source. Additionally, the contours exhibit rapid changes near the point fluid source but display gradual variations at a distance from it. These findings highlight the intricate behavior of the system under point liquid loading, offering valuable insights for further research and practical applications.
A Study of Subsurface Convection Zones of Fast Rotating Massive Stars
Authors: He Xiaolong , Lü Guoliang , Zhu Chunhua , Li Lin , Liu Helei , Guo Sufen , Lu Xizhen , Li Lei , Wang Hao 
Published: February 2025

Abstract
The subsurface convective zones (CZs) of massive stars significantly influence many of their key characteristics. Previous studies have paid little attention to the impact of rotation on the subsurface CZ, so we aim to investigate the evolution of this zone in rapidly rotating massive stars. We use the Modules for Experiments in Stellar Astrophysics to simulate the subsurface CZs of massive stars during the main sequence phase. We establish stellar models with initial masses ranging from 5 M
⊙ to 120 M
⊙, incorporating four metallicities (Z = 0.02, 0.006, 0.002, and 0.0001) and three rotational velocities (ω/ω
crit = 0, ω/ω
crit = 0.50, and ω/ω
crit = 0.75). We find that rapid rotation leads to an expansion of the subsurface CZ, increases convective velocities, and promotes the development of this zone. Additionally, subsurface CZs can also emerge in stars with lower metallicities. Comparing our models with observations of massive stars in the Galaxy, the Large Magellanic Cloud, and the Small Magellanic Cloud, we find that rotating models better encompass the observed samples. Rotation significantly influences the evolution of the subsurface CZ in massive stars. By comparing with the observed microturbulence on the surfaces of OB stars, we propose that the subsurface CZs may be one of the sources of microturbulence.
Predicting EEG seizures using graded spiking neural networks
Authors: Al Musafir Yazin , Mesbah Mostefa 
Published: February 2025

Abstract
Owing to its associated recurrent seizures, epilepsy, a prevalent neurological disorder, significantly impairs the patient’s quality of life. Effective automated seizure prediction can revolutionize epilepsy management and improve patient wellbeing. This study introduces a novel, non-patient-specific seizure prediction system powered by Graded Spiking Neural Networks (GSNNs) and optimized for Intel’s Loihi 2 neuromorphic processor. Training this innovative predictor with the widely used CHB-MIT electroencephalogram (EEG) dataset yielded promising results, outperforming traditional EEG seizure-predictio&#xD;n methodologies. Further enhancements in the prediction performance were achieved through 1) hyperparameter optimization, 2) EEG channel selection to reduce the data volume, and 3) the introduction of a time-windowed voting (TWV) mechanism for increased robustness against noise and artifacts. The system was then implemented on Intel’s Loihi 2 neuromorphic processor, and its performance was analyzed. When contrasted with traditional Artificial Neural Networks (ANNs) based systems, the GSNN-based predictor demonstrated superior efficiency and reduced computational complexity, underscoring the substantial potential of GSNNs in this domain.
Research on Anomaly Monitoring Method of Power Telecontrol Transmission Based on Feature Selection and M-LSTM
Authors: Kai Guo , Mo Zhang , Lu Zheng , Qinning Sun , Yuqing Chang , Xiaochen Zhu 
Published: February 2025

Abstract
Power telecontrol transmission system is one of the key parts of power system, and its stable operation plays a key role in the safe operation of power system. Aiming at the redundancy of characteristic variables of power telecontrol transmission data, this paper proposes a set of typical characteristic variables by analyzing transmission network architecture and transmission protocol. A multi-time-short memory model (M-LSTM) is proposed to monitor the anomalies of power telecontrol data according to the sequence of each feature. The experimental results show that the method proposed in this paper has higher monitoring accuracy for the abnormal data in the power telecontrol transmission system.