bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Investigation on the Value of Repeat and Combination Test of ACA and Anti‐β2‐GPI Antibody in Women with Recurrent Spontaneous Abortion
Authors: Bao Shi Hua , Wang Xi Peng , Lin Qi De , Di Wen , Xu Liang , Ding Chuan Wei 
Published: September 2008

Problem In order to investigate the value of anticardiolipin antibodies (ACA) and anti‐β2‐GPI antibodies detection in screening autoimmune type recurrent spontaneous abortion and its clinic application in antiphospholipid syndrome diagnosis, we adopt repeat combined ACA and anti‐β2‐GPI antibodies detection in this study.Method of study Sera were collected from patients and work‐up was done for detection of ACA and anti‐β2‐GPI antibodies by enzyme‐linked immunosorbent assay (ELISA). The work‐up was done for detection of antibodies once in every 6 weeks for 14 times consecutively.Results The repeated and combined detection of ACA and anti‐β2‐GPI antibodies detection could raise the positivity rate up to 21.8% (P < 0.05) in comparison with positive for ACA alone (14.1%), positive for anti‐β2‐GPI alone (3.1%), and concurrently positive for both ACA and anti‐β2‐GPI antibodies (4.6%). In 91 confirmed positive antiphospholipid antibodies (APA) patients, with more frequent screening for ACA and anti‐β2‐GPI antibodies, more patients with APA were found. The positive rate of five and more screenings was over 81.32%, which was statistically significant (P < 0.05), in comparison with that of four or less screenings (68.13%).Conclusion Our data implied that it would be appropriate to take over five or more screenings of combined ACA and anti‐β2‐GPI antibodies detection in suspect patients to facilitate the positive diagnostic rate for autoimmune type RSA.
Little known Eucinetidae (Coleoptera: Scirtoidea) in Korea
Authors: KIM Tae‐Kyu , AHN Kee‐Jeong 
Published: September 2008

AbstractThe beetle family Eucinetidae, represented by Eucinetus haemorrhoidalis (Germar), is newly recorded from southern parts of the Korean Peninsula, extending its distributional range by several hundred kilometers to the south. A habitus photo and illustrations of the diagnostic characters of species are provided.
Occurrence of cotton aphids (Aphis gossypii) and lady beetles (Hamonia axyridis) on Hibiscus syriacus Linne: Are the aphids a pest of cucurbits?
Authors: KIM Yong‐Heon , KIM Hwang‐Yong , KIM Jeong‐Hwan 
Published: September 2008

AbstractPopulations of cotton aphid on Hibiscus syriacus increased rapidly from 17 to 24 May 2007, and then decreased as its predator, the lady beetle Hamonia axyridis, increased in number. There was a 10 day time lag between peak populations of aphids and lady beetles. The infestation of aphids on H. syriacus produced some damage, but H. syriacus recovered soon after the lady beetles arrived. Cotton aphid clones from H. syriacus were transferred to other summer host plants: to five different vegetables on two dates, and to cucumber on three dates. Apart from one case where reproduction occurred on eggplant, most H. syriacus aphid clones did not survive on the vegetables. The cotton aphid on H. syriancus was prey and a food source for H. axyridis and acted to conserve natural enemies.
External microstructure of the ambrosia beetle Platypus koryoensis (Coleoptera: Curculionidae: Platypodinae)
Authors: MOON Myung‐Jin , PARK Jong‐Gu , OH Eunsung , KIM Kyung‐Hee 
Published: September 2008

Abstract Platypus koryoensis is a minute ambrosia beetle found in forests. It can cause significant economic damage to oak trees. Recently in Korea, it has been reported as a major pest of oak trees, because it causes sooty mold of oak by introducing the pathogenic fungus Raffaelea sp. In this paper, we demonstrate the fine structural aspects of the external body of the ambrosia beetle using field emission scanning electron microscopy, as a part of basic research into this pest so that strategies for its control might be developed. This beetle has a sensory system well developed to respond to both visual and chemical stimuli. Both sexes have a pair of faceted compound eyes and a pair of knobbed antennae, but simple eyes are absent. The mouthparts on its distinct snouts are effective devices for penetration and for boring holes. The mouthparts consist of the labrum, a pair of mandibles, a pair of maxillae and the labium. Both the maxillary and the labial palpi have the function of directing the food to the mouth and holding it while the mandibles chew the food. The distal ends of these palpi are flattened and have shovel‐like setae. The thorax has a particularly hard exoskeleton and hard elytra, including powerful muscles that operate both the wings and the legs. The legs are multi‐segmented and have a strong femur and tibia, including one pair of claws on the end of each tarsal segment. Characteristically, both male and female beetles have mycangial cavities for storing spores and other microorganisms, but only females have three pairs of large depressions on their dorsal thorax.
The biological characteristics of dendritic cells derived in vitro from myelogeneous leukemia cells and healthy donor cells
Authors: TONG X. M. , YAO H. P. , QIAN W. B. , ZHU L. F. , FU Z. H. , HUANG Z. L. , JIN J. 
Published: September 2008

SummarySuccessful adoptive immunotherapy for leukemia depends on the generation of T cells that can specifically react with malignant cells. Dendritic cells (DCs) are important antigen‐presenting cells in the development of antileukemia T‐cell responses. Mononuclear cells (MNC) were isolated from peripheral blood or bone marrow of patients with chronic myelogenous leukemia (CML), and acute myelogenous leukemia (AML). After incubation with granulocyte‐macrophage colony‐stimulating factor, interleukin (IL)‐4, and tumor necrosis factor‐α, MNC developed morphological characteristics of DCs in vitro, which were confirmed by phenotypic assay. Fluorescence in situ hybridization demonstrated the presence of fusion gene in the nuclei of representative CML or AML–M3 samples, indicating that the cells were leukemic in origin. IL‐12 levels were significantly higher in AML–DCs and CML–DCs prestimulated with phorbol 12‐myristate 13‐acetate than in the corresponding leukemic cells, but were lower than that of healthy donors. These cells were potent stimulators of lymphocyte proliferation in specific in vitro assays for DC function. However, the stimulatory abilities of allogeneic T cells in a mixed lymphocyte reaction were impaired compared with those of mature DCs derived from healthy donors, although T‐cell stimulatory effects were significantly increased in these differentiated leukemia–DCs. These results suggest that functional DCs may be derived from leukemic (AML, CML) blasts in a significant number of patients and may be capable of inducing leukemia‐specific immune responses with potentially clinically beneficial effects.
Collagen fibrillogenesis in tendon development: Current models and regulation of fibril assembly
Authors: Banos Charles C. , Thomas Amelia H. , Kuo Catherine K. 
Published: September 2008

AbstractTendons are collagen‐based fibrous tissues that connect and transmit forces from muscle to bone. These tissues, which are high in collagen type I content, have been studied extensively to understand collagen fibrillogenesis. Although the mechanisms have not been fully elucidated, our understanding has continued to progress. Here, we review two prevailing models of collagen fibrillogenesis and discuss the regulation of the process by candidate cellular and extracellular matrix molecules. Although numerous molecules have been implicated in the regulation of collagen fibrillogenesis, we focus on those that have been suggested to be particularly relevant to collagen type I fibril formation during tendon development, including members of the collagen and small leucine‐rich proteoglycan families, as well as other molecules, including scleraxis, cartilage oligomeric matrix protein, and cytoskeletal proteins. Birth Defects Research (Part C) 84:228–244, 2008. © 2008 Wiley‐Liss, Inc.
Quantitative mechanical evaluation and analysis of Drosophila embryos through the stages of embryogenesis
Authors: Shen Yantao , Zhang Rui , Cozen Scott , Xi Ning , Wejinya Uchechukwa C. , Hao Lina 
Published: September 2008

AbstractThe fruit fly Drosophila embryo is one of the most important model organisms in genetics and developmental biology research. To better understand the biomechanical properties involved in Drosophila embryo research, this work presents a mechanical characterization of living Drosophila embryos through the stages of embryogenesis. Measurements of the mechanical forces of Drosophila embryos are implemented using a novel, in situ, and minimally invasive force sensing tool with a resolution in the range of μN. The measurements offer an essential understanding of penetration force profiles during the microinjection of Drosophila embryos. Sequentially quantitative evaluation and analysis of the mechanical properties, such as Young's modulus, stiffness, and mechanical impedance of living Drosophila embryos are performed by extracting the force measurements throughout the stages of embryogenesis. Experimental results illustrate the changing mechanical properties of Drosophila embryos during development, and thus mathematical models are proposed. The evaluation provides a critical step toward better understanding of the biomechanical properties of Drosophila embryos during embryogenesis, and could contribute to more efficient and significant genetic and embryonic development research on Drosophila. Birth Defects Research (Part C) 84:204–214, 2008. © 2008 Wiley‐Liss, Inc.
Sea urchin development: An alternative model for mechanistic understanding of neurodevelopment and neurotoxicity
Authors: Falugi Carla , Lammerding‐Koppel Maria , Aluigi Maria Grazia 
Published: September 2008

AbstractEchinoderm early developmental stages might supply a good tool for toxicity testing in different fields, ranging from environment to food contamination, and in full respect of the 3Rs objectives (reduction, refinement, and replacement of animal experiments) that will eventually lead to the replacement of high vertebrate animal testing in toxicology. Sea urchin is one of the few organismic models considered by the European Agency for Alternative models. Actually, sea urchin embryonic development has been studied for over a century, and the complex nets of intercellular communications leading to the different events are well known, as well the possibility for environmental molecules and their residuals to interfere with such communications, causing developmental anomalies. In particular, the main goal of toxicologists since several years has been to establish a correlation between the cell‐to‐cell communications occurring during different developmental events and the signals occurring during neurogenesis, with the aim to pursue a mechanistic understanding of these processes and their deviations caused by stressors from different sources. Birth Defects Research (Part C) 84:188–203, 2008. © 2008 Wiley‐Liss, Inc.
Cytology of bronchial associated lymphoid tissue lymphoma
Authors: Chhieng David C. 
Published: September 2008

AbstractA 69‐year‐old man sought medical care because of persistent cough. Imaging work up revealed multiple nodules involving both lungs. Fine needle aspiration biopsy (FNA) of the right lower lobe mass was performed and revealed atypical alveolar cells in a lymphoid background. The initial cytologic interpretation was “atypical alveolar cells, probably reactive.” The patient underwent wedge resection of the right lower lobe. Intraoperative touch preparation revealed an atypical lymphoid proliferation. Histologic findings revealed multiple nodules of small and medium‐sized lymphocytes replacing the lung parenchyma; lymphoepithelial lesions, and type II pneumocytes hyperplasia were also noted. Flow cytometry demonstrated the presence of a monoclonal B‐cell population. A diagnosis of bronchial associated lymphoid tissue (BALT) lymphoma was established. The patient was treated with rituximab and was disease free 2 years after initial diagnosis. Diagn. Cytopathol. 2008;36:723–728. © 2008 Wiley‐Liss, Inc.
Cytologic feature by squash preparation of pineal parenchyma tumor of intermediate differentiation
Authors: Shimada Keiji , Nakamura Mitsutoshi , Kuga Yoshihiro , Taomoto Katsushi , Ohnishi Hideyuki , Konishi Noboru 
Published: September 2008

AbstractPineal parenchyma tumor of intermediate differentiation (PPTID) is a very rare intracranial tumor, and pathological investigation limited to immunohistological and ultrastructural analyses have been published to date. Although intraoperative cytology is one of the important approaches for initial diagnosis in brain tumors, no or little studies on cellular morphology of PPTID have been demonstrated due to its rarity. We report here cytological features of PPTID obtained from stereotactic surgical specimens in a case of 27‐year‐old female manifested by dizziness and diplopia. Brain MRI revealed an unhomogeneously enhanced, large‐sized tumor (56 × 52 × 60 mm) mainly located in the pineal region expanding from the midbrain to superior portion of the cerebellum and the fourth ventricle. Squash cytology showed increased nucleocytoplasmic ratio, hyperchromatic nuclei, and small rosette‐like cell cluster but cellular pleomorphism was mild to moderate and necrotic background was not observed. Histology showed high cellularity, moderate nuclear atypia, and small rosette formation but neither bizarre tumor cells nor necrosis was present. Mitotic counts were very low (less than 1 per 10 high‐power fields) and the MIB‐1 labeling index was relatively high (10.1%). Tumor cells were immunohistochemically positive for neural markers such as synaptophysin, neurospecific enolase but not for glial fibrillary acidic protein or S‐100. In some parts, cells were strongly reactive for neurofilament protein. Taken together, we made a final diagnosis of PPTID. This is the first presentation of cytological analysis by squash preparation that gives an important clue to accurate diagnosis of pineal parenchymal tumor and to understand its malignant potential. Diagn. Cytopathol. 2008;36:749–753. © 2008 Wiley‐Liss, Inc.
Apocrine (cutaneous) sweat gland carcinoma of axilla with signet ring cells: A diagnostic dilemma on fine‐needle aspiration cytology
Authors: Pai Radha R. , Kini Jyoti R. , Achar Chandrayya , Rau Aarathi , Kini Hema 
Published: September 2008

AbstractCarcinoma arising in the apocrine sweat glands is rare and there are few reports describing the cytological features of this neoplasm. We describe the cytological features of a histologically confirmed apocrine carcinoma occurring in a 55‐year‐old man who presented with an ulcerated mass in the right axilla. Fine‐needle aspiration cytology revealed features of a signet ring adenocarcinoma. The significance of this infrequently encountered neoplasm lies in its potential for diagnostic confusion with more common lesions containing signet ring cells. In an axillary mass lesion, cytological features along with clinical correlation are essential to distinguish primary apocrine carcinoma from mammary neoplasms with signet ring cells and other metastatic adenocarcinomas. Diagn. Cytopathol. 2008;36:739–741. © 2008 Wiley‐Liss, Inc.
Malignant epithelial tumors and hematologic malignancy
Authors: Marković‐Glamočak Mirjana , Sučić Mirna , Ries Sunčica , Gjadrov‐Kuveždić Koraljka , Labar Boris 
Published: September 2008

AbstractThe aim of this study was to analyze the value of cytology in differentiation between malignant epithelial tumor metastases and hematologic malignancy.The follow‐up of ten (10) patients who underwent diagnosis and treatment of two malignant diseases, i.e. carcinoma and hematologic malignancy, was performed in the 2000–2005 period. The median of age of our patients was 72 years (range: 49–79). Cytological examination included epithelial tumors, lymph nodes and bone marrow standard Pappenheim and immunocytochemically stained smears.Carcinoma was initially diagnosed in 40% (4/10) patients and hematologic malignancy in 50% (5/10) patients, while both diseases co‐occurred in one patient (1/10).Most of hematologic malignancy cases (4/10) were diagnosed as lymphoma. Multiple myeloma was diagnosed in 3 out of 10 patients (30%). Individual cases of acute myeloblastic leukemia, chronic lymphocytic leukemia, and chronic myeloid leukemia were diagnosed in the remaining three patients. Most carcinomas were breast cancer (8/10), while prostate and thyroid gland cancer were diagnosed each in one patient, respectively. Diagn. Cytopathol. 2008;36:710–714. © 2008 Wiley‐Liss, Inc.
Increased detection of clue cells in smears from cervical intraepithelial lesions with reduced expression of COX‐2
Authors: Figueiredo Priscila Garcia , Sarian Luis Otávio , Tambascia Julia Kawamura , Simões José Antônio , Rabelo‐Santos Silvia Helena , Discacciati Michelle Garcia , Derchain Sophie 
Published: September 2008

AbstractThe relation between the detection of clue cells in cervical smears of women with CIN and the expression of COX‐2 in these lesions were determined. Samples from 228 women, treated due to CIN and who underwent cervical conization, were obtained. Hybrid Capture II and Pap smear samples were collected immediately before performing conization. Pathological diagnoses were 11 (5%) normal cervix, 35 (15%) CIN1, 31 (14%) CIN2, and 151 (66%) CIN3. COX‐2 immunoreactivity grading on the pathological specimens was based on the German ImmunoReactive score. In cervical smears, 20 fields (40x) were examined, each of them with a minimum count of 10 epithelial cells. When 20% or more of clue cells were detected the sample was considered positive for clue cells. The prevalence of clue cells was similar across histological strata (P = 0.42). Although the expression of COX‐2 did not differ in lesions with varying severities (P = 0.24), there was a negative association between the expression of COX‐2 and the presence of clue cells in Pap smear (OR = 0.4; 95% CI = 0.2–0.9): only 12% of women with moderate and strong expression of COX‐2 had clue cells in their smears, contrasted to 22% of those with negative and weak expression of COX‐2. HPV infection was associated in a borderline manner to the expression of COX‐2 (P = 0.04; OR = 2.3 95% CI = 1.0–5.4). The reduced expression of COX‐2 in CIN specimens may suggest that clue cells interfere with the inflammatory component of the carcinogenic process that lead to CIN. Diagn. Cytopathol. 2008;36:705–709. © 2008 Wiley‐Liss, Inc.
Cytologic features of primary chondroid tumors of bone in crush preparations
Authors: Cabay Robert J. , Reddy Vijaya , David Odile , McIntire Maria , Cimbaluk David , Kasuganti Deepa , Gould Victor , Gattuso Paolo 
Published: September 2008

AbstractFine‐needle aspiration biopsy can be utilized effectively in the diagnosis of many bone lesions. Often, these lesions are suspected to be foci of metastatic disease based on clinical and/or radiographic findings. On occasion, microscopic examination of the aspirate yields a diagnosis of a primary neoplasm of chondroid origin. We discuss the cytologic features observed in crush preparations of the most frequently seen primary chondroid tumors of bone and how these lesions can be differentiated from each other and from metastatic lesions. Diagn. Cytopathol. 2008;36:758–761. © 2008 Wiley‐Liss, Inc.
Reactions of nitroxides, part 7: Synthesis of novel nitroxide selenoureas
Authors: Zakrzewski Jerzy , Krawczyk Maria 
Published: September 2008

AbstractThe reactions of 4‐isoselenocyanato‐2,2,6,6‐tetramethylpiperidine‐1‐oxyl with selected amines and lower alcohols give the corresponding novel selenoureas and selenocarbamates, all bearing the nitroxyl moiety. Some of the synthesized selenoureas and selenocarbamates show moderate‐to‐good activity against pathogenic fungi. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:549–556, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20454
Effects of electron‐withdrawing group on the photoisomerization of tetraaryl‐4H‐thiopyran‐1,1‐dioxides
Authors: Jafarpour Farnaz , Ramezani Fatemeh , Pirelahi Hooshang 
Published: September 2008

AbstractSyntheses and photoisomerization of the new sulfone derivatives, 4,4‐di (p‐trifluoromethylphenyl)‐2,6‐diphenyl‐4H‐thiopyran‐1, 1‐dioxide and 4‐(p‐trifluoromethylphenyl)‐2,4,6‐triphenyl‐4H‐thiopyran‐1,1‐dioxide, have been investigated. The relative molar ratios of the photoproducts are compared with those of 2,4,4,6‐tetraphenyl‐4H‐thiopyran‐1,1‐dioxide as well as electron‐donating substituted 4‐methyl‐2,4,6‐triaryl‐4H‐thiopyran‐1,1‐dioxides as model compounds under identical experimental conditions using 1H NMR spectroscopy. The results observed are discussed on the basis of a triplet excited state di‐π‐methane rearrangement. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:557–561, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20455
Synthesis of new functionalized mono‐ and bisphosphinates with 2,6‐di‐tert‐butyl‐4‐methylphenol fragments
Authors: Prishchenko Andrey A. , Livantsov Mikhail V. , Novikova Olga P. , Livantsova Ludmila I. , Milaeva Elena R. 
Published: September 2008

AbstractConvenient procedures for the synthesis of functionalized mono‐ and bisphosphinates with 2,6‐di‐tert‐butyl‐4‐methylphenol (ionol) fragments, starting from the available 3,5‐di‐tert‐butyl‐4‐benzaldehyde and its derivatives, are proposed, and some properties of the new phosphorus‐substituted sterically hindered phenols are presented. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:562–568, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20475
A convenient synthesis of novel 7‐phosphonylbenzyl‐2‐substituted pyrazolo[4,3‐e]‐1,2,4‐triazolo[1,5‐c]‐pyrimidine derivatives
Authors: Xiao Lin‐Xia , Li Ke , Meng Liu , Shi De‐Qing 
Published: September 2008

AbstractA series of pyrazolo[4,3‐e]‐1,2,4‐triazolo‐[1,5‐c]pyrimidine derivatives, bearing phosphonylbenzyl chain in position 7, were conveniently synthesized in an attempt to obtain potent and selective antagonists for the A2Aadenosine receptor or potent pesticide lead compounds. Diethyl[(5‐amino‐4‐cyano‐3‐methylsulfanyl‐pyrazol‐1‐yl)‐benzyl]phospho‐nate (3), which was prepared by the cyclization of diethyl 1‐hydrazinobenzylphosphonate (1) with 2‐[bis(methylthio)methylene]malononitrile (2), reacted with triethyl orthoformate to afford diethyl[(4‐cyano‐5‐ethoxymethyleneamino‐3‐methylsulfanyl‐pyrazol‐1‐yl)‐benzyl]phosphonate (4), which reacted with various acyl hydrazines in refluxing 2‐methoxyethanol to give the target compounds5a–hin good yields. Their structures were confirmed by IR,1H NMR,13C NMR, MS, and elemental analysis. The crystal structure of5ewas determined by single crystal X‐ray diffraction © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:634–638, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20478
Palladium N‐heterocyclic‐carbene‐catalyzed ortho‐arylation of benzaldehyde derivatives
Authors: Dogan Öznur , Gürbüz Nevin , Özdemir İsmail , Çetinkaya Bekir 
Published: September 2008

AbstractNew, sterically demanding 1,3‐dialkylbenzimidazolium salts (2a–c) as N‐heterocyclic‐carbene precursors have been synthesized and characterized. The ortho position of aromatic aldehydes was directly and selectively arylated with aryl chlorides in the presence of a catalytic system prepared in situ from Pd(OAc)2, 1,3‐dialkylbenzimidazolium chlorides (2a–c), and Cs2CO3. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:569–574, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20479