bluuebunny/crossref_metadata_2025_split huggingface dataset:
Richard Kearney's hermeneutics of Otherness
Authors: Masterson Patrick 
Published: February 2008

The article considers a particular case of Richard Kearney's characteristic hermeneutical exploration of `the possible' as an `imaginative' way of casting light upon philosophical issues. This particular case is his recent hermeneutical and phenomenological consideration of `Otherness' in the context of philosophy of religion. This consideration, strongly influenced by philosophers such as Heidegger, Levinas, Ricoeur and Derrida, is developed in two of his recent works Strangers, Gods and Monsters and The God Who May Be. The article examines how he seeks to navigate an interpretation of divine otherness as an ethical appeal which escapes the dilemma of a God either so transcendent as to be anonymous or so immanent as to be a mere projection. It outlines how, rejecting onto-theology in favour of eschatology, Kearney envisages the divine as an ethically enabling possibility. This possibility, he claims, enables us to achieve, beyond our own intrinsic resources, an ethical order of justice and love through which the kingdom of God — the God Who May Be — is accomplished. There is a co-relativity between the divine as enabling possibility and humanity which accomplishes this possibility. It investigates the way in which Kearney seeks to legitimize, within a phenomenological frame of reference, an experiential affirmation of this conception of divine transcendence as eschatological possibility. It argues that this phenomenological consideration needs to be qualified and complemented by certain metaphysical considerations which Kearney disputes.
Overexpressed NF-κB–inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells
Authors: Saitoh Yasunori , Yamamoto Norio , Dewan M. Zahidunnabi , Sugimoto Haruyo , Martinez Bruyn Vicente J. , Iwasaki Yuki , Matsubara Katsuyoshi , Qi Xiaohua , Saitoh Tatsuya , Imoto Issei , Inazawa Johji , Utsunomiya Atae , Watanabe Toshiki , Masuda Takao , Yamamoto Naoki , Yamaoka Shoji 
Published: February 2008

AbstractThe nuclear factor-κB (NF-κB) transcription factors play important roles in cancer development by preventing apoptosis and facilitating the tumor cell growth. However, the precise mechanisms by which NF-κB is constitutively activated in specific cancer cells remain largely unknown. In our current study, we now report that NF-κB–inducing kinase (NIK) is overexpressed at the pretranslational level in adult T-cell leukemia (ATL) and Hodgkin Reed-Sternberg cells (H-RS) that do not express viral regulatory proteins. The overexpression of NIK causes cell transformation in rat fibroblasts, which is abolished by a super-repressor form of IκBα. Notably, depletion of NIK in ATL cells by RNA interference reduces the DNA-binding activity of NF-κB and NF-κB–dependent transcriptional activity, and efficiently suppresses tumor growth in NOD/SCID/γcnull mice. These results indicate that the deregulated expression of NIK plays a critical role in constitutive NF-κB activation in ATL and H-RS cells, and suggest also that NIK is an attractive molecular target for cancer therapy.
DBMLoc: a Database of proteins with multiple subcellular localizations
Authors: Zhang Song , Xia Xuefeng , Shen Jincheng , Zhou Yun , Sun Zhirong 
Published: February 2008

Abstract

Background
Subcellular localization information is one of the key features to protein function research. Locating to a specific subcellular compartment is essential for a protein to function efficiently. Proteins which have multiple localizations will provide more clues. This kind of proteins may take a high proportion, even more than 35%.

Description
We have developed a database of proteins with multiple subcellular localizations, designated DBMLoc. The initial release contains 10470 multiple subcellular localization-annotated entries. Annotations are collected from primary protein databases, specific subcellular localization databases and literature texts. All the protein entries are cross-referenced to GO annotations and SwissProt. Protein-protein interactions are also annotated. They are classified into 12 large subcellular localization categories based on GO hierarchical architecture and original annotations. Download, search and sequence BLAST tools are also available on the website.

Conclusion
DBMLoc is a protein database which collects proteins with more than one subcellular localization annotation. It is freely accessed at http://www.bioinfo.tsinghua.edu.cn/DBMLoc/index.htm.
Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease
Authors: Koprich James B , Reske-Nielsen Casper , Mithal Prabhakar , Isacson Ole 
Published: February 2008

Abstract

Background
The etiology of Parkinson's disease (PD) remains elusive despite identification of several genetic mutations. It is more likely that multiple factors converge to give rise to PD than any single cause. Here we report that inflammation can trigger degeneration of dopamine (DA) neurons in an animal model of Parkinson's disease.

Methods
We examined the effects of inflammation on the progressive 6-OHDA rat model of Parkinson's disease using immunohistochemistry, multiplex ELISA, and cell counting stereology.

Results
We show that a non-toxic dose of lipopolysaccharide (LPS) induced secretion of cytokines and predisposed DA neurons to be more vulnerable to a subsequent low dose of 6-hydroxydopamine. Alterations in cytokines, prominently an increase in interleukin-1beta (IL-1β), were identified as being potential mediators of this effect that was associated with activation of microglia. Administration of an interleukin-1 receptor antagonist resulted in significant reductions in tumor necrosis factor-α and interferon-γ and attenuated the augmented loss of DA neurons caused by the LPS-induced sensitization to dopaminergic degeneration.

Conclusion
These data provide insight into the etiology of PD and support a role for inflammation as a risk factor for the development of neurodegenerative disease.
Design and End Points of Clinical Trials for Patients With Progressive Prostate Cancer and Castrate Levels of Testosterone: Recommendations of the Prostate Cancer Clinical Trials Working Group
Authors: Scher Howard I. , Halabi Susan , Tannock Ian , Morris Michael , Sternberg Cora N. , Carducci Michael A. , Eisenberger Mario A. , Higano Celestia , Bubley Glenn J. , Dreicer Robert , Petrylak Daniel , Kantoff Philip , Basch Ethan , Kelly William Kevin , Figg William D. , Small Eric J. , Beer Tomasz M. , Wilding George , Martin Alison , Hussain Maha 
Published: February 2008

PurposeTo update eligibility and outcome measures in trials that evaluate systemic treatment for patients with progressive prostate cancer and castrate levels of testosterone.MethodsA committee of investigators experienced in conducting trials for prostate cancer defined new consensus criteria by reviewing previous criteria, Response Evaluation Criteria in Solid Tumors (RECIST), and emerging trial data.ResultsThe Prostate Cancer Clinical Trials Working Group (PCWG2) recommends a two-objective paradigm: (1) controlling, relieving, or eliminating disease manifestations that are present when treatment is initiated and (2) preventing or delaying disease manifestations expected to occur. Prostate cancers progressing despite castrate levels of testosterone are considered castration resistant and not hormone refractory. Eligibility is defined using standard disease assessments to authenticate disease progression, prior treatment, distinct clinical subtypes, and predictive models. Outcomes are reported independently for prostate-specific antigen (PSA), imaging, and clinical measures, avoiding grouped categorizations such as complete or partial response. In most trials, early changes in PSA and/or pain are not acted on without other evidence of disease progression, and treatment should be continued for at least 12 weeks to ensure adequate drug exposure. Bone scans are reported as “new lesions” or “no new lesions,” changes in soft-tissue disease assessed by RECIST, and pain using validated scales. Defining eligibility for prevent/delay end points requires attention to estimated event frequency and/or random assignment to a control group.ConclusionPCWG2 recommends increasing emphasis on time-to-event end points (ie, failure to progress) as decision aids in proceeding from phase II to phase III trials. Recommendations will evolve as data are generated on the utility of intermediate end points to predict clinical benefit.
Phase III Trial of Trimodality Therapy With Cisplatin, Fluorouracil, Radiotherapy, and Surgery Compared With Surgery Alone for Esophageal Cancer: CALGB 9781
Authors: Tepper Joel , Krasna Mark J. , Niedzwiecki Donna , Hollis Donna , Reed Carolyn E. , Goldberg Richard , Kiel Krystyna , Willett Christopher , Sugarbaker David , Mayer Robert 
Published: February 2008

Purpose The primary treatment modality for patients with carcinoma of the esophagus or gastroesophageal junction has been surgery, although primary radiation therapy with concurrent chemotherapy produces similar results. As both have curative potential, there has been great interest in the use of trimodality therapy. To this end, we compared survival, response, and patterns of failure of trimodality therapy to esophagectomy alone in patients with nonmetastatic esophageal cancer. Patients and Methods Four hundred seventy-five eligible patients were planned for enrollment. Patients were randomly assigned to either esophagectomy with node dissection alone or cisplatin 100 mg/m2 and fluorouracil 1,000 mg/m2/d for 4 days on weeks 1 and 5 concurrent with radiation therapy (50.4 Gy total: 1.8 Gy/fraction over 5.6 weeks) followed by esophagectomy with node dissection. Results Fifty-six patients were enrolled between October 1997 and March 2000, when the trial was closed due to poor accrual. Thirty patients were randomly assigned to trimodality therapy and 26 were assigned to surgery alone. Patient and tumor characteristics were similar between groups. Treatment was generally well tolerated. Median follow-up was 6 years. An intent-to-treat analysis showed a median survival of 4.48 v 1.79 years in favor of trimodality therapy (exact stratified log-rank, P = .002). Five-year survival was 39% (95% CI, 21% to 57%) v 16% (95% CI, 5% to 33%) in favor of trimodality therapy. Conclusion The results from this trial reflect a long-term survival advantage with the use of chemoradiotherapy followed by surgery in the treatment of esophageal cancer, and support trimodality therapy as a standard of care for patients with this disease.
Outcomes of Adrenalectomy for Isolated Synchronous Versus Metachronous Adrenal Metastases in Non–Small-Cell Lung Cancer: A Systematic Review and Pooled Analysis
Authors: Tanvetyanon Tawee , Robinson Lary A. , Schell Michael J. , Strong Vivian E. , Kapoor Rachna , Coit Daniel G. , Bepler Gerold 
Published: February 2008

Purpose Several small studies have reported that an adrenalectomy for isolated adrenal metastasis in non–small-cell lung cancer (NSCLC), along with a surgical resection for the primary lung cancer, can be curative. However, some suggest that the survival outcome among patients with a synchronous metastasis is poor. It remains unclear whether this treatment approach is warranted among those with synchronous metastasis. Methods A search for publications on adrenalectomy for NSCLC was performed via the MEDLINE database. Studies reporting on survival outcomes and containing at least four analyzable patients who had surgery for primary lung cancer were included. Those not allowing separation of outcomes between synchronous and metachronous metastases were excluded. Synchronous metastasis was defined as a disease-free interval (DFI) of 6 months or less. Results There were 10 publications contributing 114 patients; 42% of patients had synchronous metastases and 58% had metachronous metastases. The median DFIs were 0 and 12 months, respectively. Patients in the synchronous group were younger than those in the metachronous group (median age 54 v 68 years). Complications from adrenalectomy were infrequent. Median overall survival was shorter for patients with synchronous metastasis than those with metachronous metastasis (12 months v 31 months, generalized Wilcoxon P value = .02). However, the 5-year survival estimates were equivalent at 26% and 25%, respectively. Conclusion For an isolated adrenal metastasis from NSCLC, patients with a synchronous metastasis who underwent adrenalectomy had a shorter median overall survival than those with a metachronous metastasis. However, a durable long-term survival is achieved in approximately 25% in both groups.
Microfluidic Fabrication-induced Luminescence of C60 Rods
Authors: Shinohara Kyosuke , Someya Satoshi , Abe Hiroaki , Suemoto Tohru , Okamoto Koji 
Published: February 2008

Abstract
C60 rods were fabrication using a microfluidic liquid–liquid interfacial precipitation method at 17 °C. Using photoluminescence spectroscopy, it was found that the alcohol solvent molecules affect the excitation and emission properties of the C60 rods. This suggests that the microfluidic fabrication induces doping of alcohol solvents and a change in the optoelectronic properties of C60 crystals.
Kυματι Θαλασσησ …
Authors: Papagiannis Grigorios 
Published: February 2008

Abstract
Την αфοϱμή για τις παϱαϰάτω σϰέψεις μού έδωσαν δημοσιεύματα: α) G. SCHIRÒ, La seconda leggenda di Cassia, Δίπτυχα 1 (1979) 300–315 ϰαι β) Θ. ΔЕΤОРАКΗΣ, Кοσμας ο Мελωδóς, Вίος ϰαι εϱγο. Άνάλεϰτα Вλατάδων, 28. Θεσσαλονίϰη 1979, ϰυϱίως σελ. 169–177. Оι δύο εϱευνητές (την ίδια εποχή ϰαι, υποθέτω, ανεξάϱτητα ο ένας απó τον άλλο) διατυπώνουν την άποψη óτι οι ειϱμοί Кύματι θαλάσσης, Σε τòν επι υδάτων, Την εν Σταυϱω σου θείαν ϰένωσιν ϰαι Θεοфανείας σου, Хϱιστέ δεν είναι έϱγα της ποιήτϱιας Кασίας, óπως πιστευóταν, αλλά μποϱούν (σχεδóν με βεβαιóτητα) να αποδοθούν στον Кοσμά τον Мελωδó. Аλλά ας συνοψίσω πϱώτα τα δεδομένα για τους λιγóτεϱο ενήμεϱους επί του θώματος.
Glasgewichte für Follis-Prägungen aus der Zeit des Kaisers Justinos II
Authors: Schilbach Erich 
Published: February 2008

Abstract
Die Funktion byzantinischer Glasgewichte ist noch immer in mancher Weise ungeklärt. Bisweilen wurde sogar bestritten, dass es sich um Gewichte handelt. Große Schwierigkeiten bereiten zudem die Auflösung der Monogramme und die Datierung. Sehr viele Gewichte zeigen Köpfe von Kaisern oder Eparchen, meistens mit Inschriften oder Monogrammen der Beamten, oft aber auch nur die Inschriften oder Monogramme. Was – übrigens im Unterschied zu den Metallgewichten – mit wenigen Ausnahmen fehlt, sind die Nennwerte. Drei Glasgewichte mit den Nennwerten S = 6 scripula (Istgewicht 1,05 g), IB = 12 scripula (Istgewicht 2,27 g) und das dritte mit Kreuzmonogramm für ΘЕОΔΩРОΥ zwischen dem Nennwert No und A für Nó(μισμα) A′ = 1 Nomisma (Istgewicht 4,5 g) wurden bisher veröffentlicht. Zwei weitere Glasgewichte mit Nennwert sind bekannt, auf die weiter unten eingegangen wird („Gewichte D und E“). Für alle anderen Glasgewichte ist die Münzeinheit aus dem Istgewicht nur zu erschließen. Konsens ist, dass mit den Glasgewichten der Goldsolidus mit seinen Fraktionen Semissis und Tremissis und die leichtgewichtigen Solidi gewogen wurden.
Ein unbekanntes byzantinisches Kleinkapitell aus Kauniōn Panormos
Authors: Zäh Alexander 
Published: February 2008

Abstract

Einleitung

Die Ausbreitung des Massentourismus und die Grundstücksspekulation gefährden frühbyzantinische und byzantinische archäologische Stätten im südwestlichen Kleinasien akut. Wie nun schon in den 1980er Jahren ein Vier-Sterne-Hotel einer spanischen Hotelkette direkt in das weit ausgedehnte spätantike und byzantinische Ruinengebiet von Kauniōn Panormos, das mittelalterliche Prepia (der heutige Name des benachbar ten Örtchens ist Sarigerme), das an der Mündung des Sarisu Çayi – zu deutsch: Gelbwasser-Fluß – im westlichen Lykien gelegen ist, hineingebaut wurde, so sind nun schon vorbereitende Hotelbauarbeiten im Auftrage einer weiteren europäischen Hotelkette mitten im spätantiken Ruinengebiet der Ala-Kilise-Bucht (Anastasioúpolis?) in Karien im vollen Gange, nun soll hier in der Nähe noch eine Appartmenthaussiedlung entstehen. Ein Hilferuf des Verfassers bei der UNESCO Suborganisation ICOMOS verhallte bisher ungehört. Das Ruinengebiet von Sarigerme befindet sich südwestlich von Dalaman und südöstlich der Polis Kaunos. Auf der Kauniōn Panormos (Prepia) unmittelbar vorgelagerten Papas-Insel (Baba Adasi) befindet sich die Ruine eines antiken Mausoleums oder eines Leuchtturms und genauso wie Kaunos verfügte das Bistum (Kaunion) Panormos über ein in der Spätantike allerdings wohl noch intaktes, heute versumpftes, Hafenbecken. Offenbar im Zuge von Bauarbeiten in der Hotelanlage von Sarigerme wurden zwei im Ruinengebiet gefundene Kapitelle vor die Lobby des Hotels verschleppt. Es handelt sich hierbei zum einen um ein größeres korinthisches Normalkapitell aus Marmor mit einer durch ein Profil zweigeteilten Abakusleiste (vgl. Abb. 1), das möglicherweise ursprünglich aus einer der beiden großen Basiliken – von denen eine die Bischofskirche gewesen sein wird – des Ortes stammt und welches dem 5./6. Jh. zugeordnet werden kann, zum anderen um ein byzantinisches Kleinkapitell aus feinkristallinem weißen Marmor (vgl. Abb. 2–4). Das größere korinthische Kapitell gehört zu einem weit verbreiteten Standardtypus und soll deswegen hier nicht weiter besprochen werden. Das Kleinkapitell zeigt jedoch ein einzigartig gestaltetes Dekor, für das dem Verfasser bisher kein direktes Vergleichsbeispiel bekannt ist und das, durch diese kurze Vorlage, sicherlich eine Bereicherung des provinziellen byzantinischen Bauplastik-Katalogs sein wird.
Jonathan BARDILL, Brickstamps of Constantinople
Authors: Ousterhout Robert 
Published: February 2008

Abstract
Anyone who has delved into Roman archaeology understands the importance of brickstamps as an archaeological tool. Properly decoded, brickstamps have much to tell us about both the construction industry and the chronology of monuments in and around ancient Rome. Rome has enjoyed centuries of detailed archaeological investigation combined with the study of related texts. Constantinople is another story. Considerably less of its ancient core has been excavated, many of its standing buildings have not been thoroughly studied, and the identification and chronology of many of its monuments continue to elude scholars.
Sofia KOTZAMPASE, Вυζαντινά χειϱόγϱαφα από τα μοναστήϱια της Мιϰϱάς Аσίας
Authors: Gamillscheg Ernst 
Published: February 2008

Abstract
Vorgestellt werden in der vorliegenden Publikation Handschriften aus den Klöstern Kleinasiens; diese Definition bedeutet nicht, dass die präsentierten Manuskripte auch in Kleinasien entstanden sind. Wie bereits in der Diskussion auf dem Kongreß für griechische Paläographie in Erice (1988) festgestellt wurde, ist jedoch das Problem der Abgrenzung Kleinasiens vom Hinterland Konstantinopels nicht leicht zu lösen. Ein Beispiel dafür ist das Kloster Galakrenon, für das mit Cod. Vat. gr. 463, kopiert von Symeon, eine Handschrift mit starker Nähe zur Buchproduktion in der Hauptstadt (bzw. deren Peripherie) erhalten ist.
Stephen H. RAPP JR., Studies in medieval Georgian historiography: Early texts and Eurasian contexts. Corpus Scriptorum Christianorum Orientalium, 601; Subsidia, 113
Authors: Thomson Robert W. 
Published: February 2008

Abstract
Stephen RAPP (R.) has embarked on a very ambitious project – to investigate Georgian cultural contacts with the Byzantine and Iranian worlds through Georgian historial writing from its beginnings to medieval times. This involves nothing less than a presentation in English of all the relevant texts, save where a recent translation has already made them accessible, a survey of modern scholarship in Georgian as well as western languages, and a critical assessment of the dates of composition of the various works, their motivation and reception. The volume under review is the first of a planned trilogy. Based on research dating back over a decade, it concentrates on those texts in the Georgian “Chronicles” which predate the political unification of the country. The second volume will tackle the literary dimension of Georgia's conversion to Christianity, the invention of a native script, and the beginnings of ecclesiastical literature; while the third volume will study the reorientation of the Georgian élite from their original Iranian background towards the Byzantine world as this is reflected in local historiography. All in all, this massive undertaking will update, expand and carry forward the work of Cyril TOUMANOFF reflected in his Studies in Christian Caucasian History, which was published exactly forty years before R.'s first volume appeared.
Dynamics of the effective capillary cross-sectional area during the alkaline impregnation of eucalyptus wood
Authors: Inalbon M. Cristina , Zanuttini Miguel 
Published: February 2008

Abstract
Wood diffusion is strongly affected by the effective capillary cross-sectional area (ECCSA), which is the area of paths available for diffusion. The ECCSA varies dynamically according to the conditions and progress of the alkaline action. The alkali diffusion in natural wood is a complex process in the course of which the local transport properties are modified by chemical reactions and swelling. A method was developed which allows the fast determination of ECCSA as a result of the dynamic process. It is based on measurements of the relative electrical conductivity through thin wood slices. It is assumed that restrictions in diffusion of thin slices can be neglected regardless of alkali action. The evolution of ECCSA was determined in transverse directions of eucalyptus wood. The influence of temperature, alkali concentration and time was established. As demonstrated earlier, alkalinity had a strong effect on the ECCSA at room temperature, which is dramatically increased when the pH is elevated from 12.5 to 13.5. At high temperatures, the steep increase in the ECCSA appears at pH 10.5. It was also demonstrated that the degree of the chemical action – indicated by the deacetylation level – is also very relevant, being even higher than the temperature effect.