bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomized double‐blind pilot study to evaluate the efficacy, safety, and tolerability of intravenous iron versus oral iron for the treatment of restless legs syndrome in patients with iron deficiency anemia
Authors: Short Vanessa , Allen Richard , Earley Christopher J. , Bahrain Huzefa , Rineer Stella , Kashi Kiumarce , Gerb Jesse , Auerbach Michael 
Published: March 2024

AbstractRestless legs syndrome (RLS) is a neurological disorder that can have a profound effect on sleep and quality of life. Idiopathic RLS is associated with brain iron insufficiency despite normal peripheral iron stores. There is, however, a five‐ to six‐fold increase in prevalence of RLS in patients with iron deficiency anemia (IDA). Several open‐label trials have demonstrated symptomatic improvement in RLS following treatment of IDA using oral or intravenous iron supplementation. To date, there have been no randomized double‐blind controlled trials of intravenous iron compared with oral iron for the treatment of RLS patients with IDA. In the current study, oral ferrous sulfate and ferumoxytol were compared for efficacy and speed of response for treatment of RLS occurring in patients with IDA. The planned recruitment for this study was 70 patients with RLS and IDA, to be randomly assigned 1:1 to oral or intravenous iron, using double‐blind, double‐dummy procedures. At Week 6, the primary outcomes of Clinical Global Impression—Improvement score and change from baseline in the International Restless Legs Syndrome Study Group rating scale score were assessed. Due to challenges, performing the clinical trial during the COVID‐19 pandemic, final‐week data were found missing for 30 patients. As a result, in order to maintain the prespecified statistical analysis, an additional 30 patients were recruited. Both IV and oral iron were associated with a marked improvement in RLS symptoms, with no statistically significant difference between treatment groups. No serious adverse events were observed in either treatment group.
Double blind randomized controlled trial measuring the efficacy of nebulized steroid at half dose in comparison to high volume squeeze bottle steroid irrigation in management of patients with chronic rhinosinusitis
Authors: Megow Anna , Bouras George , Ooi Eng H. , Vreugde Sarah , Psaltis Alkis , Wormald Peter‐John 
Published: March 2024

Key points
Nebulized budesonide is effective at half dose compared to budesonide irrigation in CRS.
Nasal nebulizers provide an alternative for delivery of topical steroids to the sinuses.
Amyloid pathology and vascular risk are associated with distinct patterns of cerebral white matter hyperintensities: A multicenter study in 3132 memory clinic patients
Authors: Biesbroek J. Matthijs , Coenen Mirthe , DeCarli Charles , Fletcher Evan M. , Maillard Pauline M. ,   Alzheimer's Disease Neuroimaging Initiative, Barkhof Frederik , Barnes Josephine , Benke Thomas , Chen Christopher P. L. H. , Dal‐Bianco Peter , Dewenter Anna , Duering Marco , Enzinger Christian , Ewers Michael , Exalto Lieza G. , Franzmeier Nicolai , Hilal Saima , Hofer Edith , Koek Huiberdina L. , Maier Andrea B. , McCreary Cheryl R. , Papma Janne M. , Paterson Ross W. , Pijnenburg Yolande A. L. , Rubinski Anna , Schmidt Reinhold , Schott Jonathan M. , Slattery Catherine F. , Smith Eric E. , Sudre Carole H. , Steketee Rebecca M. E. , Teunissen Charlotte E. , van den Berg Esther , van der Flier Wiesje M. , Venketasubramanian Narayanaswamy , Venkatraghavan Vikram , Vernooij Meike W. , Wolters Frank J. , Xin Xu , Kuijf Hugo J. , Biessels Geert Jan 
Published: March 2024

AbstractINTRODUCTIONWhite matter hyperintensities (WMH) are associated with key dementia etiologies, in particular arteriolosclerosis and amyloid pathology. We aimed to identify WMH locations associated with vascular risk or cerebral amyloid‐β1‐42 (Aβ42)‐positive status.METHODSIndividual patient data (n = 3,132; mean age 71.5 ± 9 years; 49.3% female) from 11 memory clinic cohorts were harmonized. WMH volumes in 28 regions were related to a vascular risk compound score (VRCS) and Aß42 status (based on cerebrospinal fluid or amyloid positron emission tomography), correcting for age, sex, study site, and total WMH volume.RESULTSVRCS was associated with WMH in anterior/superior corona radiata (B = 0.034/0.038, p < 0.001), external capsule (B = 0.052, p < 0.001), and middle cerebellar peduncle (B = 0.067, p < 0.001), and Aß42‐positive status with WMH in posterior thalamic radiation (B = 0.097, p < 0.001) and splenium (B = 0.103, p < 0.001).DISCUSSIONVascular risk factors and Aß42 pathology have distinct signature WMH patterns. This regional vulnerability may incite future studies into how arteriolosclerosis and Aß42 pathology affect the brain's white matter.Highlights
Key dementia etiologies may be associated with specific patterns of white matter hyperintensities (WMH).
We related WMH locations to vascular risk and cerebral Aβ42 status in 11 memory clinic cohorts.
Aβ42 positive status was associated with posterior WMH in splenium and posterior thalamic radiation.
Vascular risk was associated with anterior and infratentorial WMH.
Amyloid pathology and vascular risk have distinct signature WMH patterns.
Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial
Authors: Howard Robert , Cort Elizabeth , Rawlinson Charlotte , Wiegand Martin , Downey Anne , Lawrence Vanessa , Banerjee Sube , Bentham Peter , Fox Chris , Harwood Rowan , Hunter Rachel , Livingston Gill , Moniz‐Cook Esme , Panca Monica , Raczek Malgorzata , Ivenso Chineze , Russell Gregor , Thomas Alan , Wilkinson Philip , Freemantle Nicholas , Gould Rebecca 
Published: March 2024

AbstractINTRODUCTIONTrials of effectiveness of treatment options for depression in dementia are an important priority.METHODSRandomized controlled trial to assess adapted Problem Adaptation Therapy (PATH) for depression in mild/moderate dementia caused by Alzheimer's disease.RESULTSThree hundred thirty‐six participants with mild or moderate dementia, >7 on Cornell Scale for Depression in Dementia (CSDD), randomized to adapted PATH or treatment as usual. Mean age 77.0 years, 39.0% males, mean Mini‐Mental State Examination 21.6, mean CSDD 12.9. For primary outcome (CSDD at 6 months), no statistically significant benefit with adapted PATH on the CSDD (6 months: −0.58; 95% CI −1.71 to 0.54). The CSDD at 3 months showed a small benefit with adapted PATH (−1.38; 95% CI −2.54 to −0.21) as did the EQ‐5D (−4.97; 95% CI −9.46 to −0.48).DISCUSSIONAn eight‐session course of adapted PATH plus two booster sessions administered within NHS dementia services was not effective treatment for depression in people with mild and moderate dementia. Future studies should examine the effect of more intensive and longer‐term therapy.
Rational Lithium Salt Molecule Tuning for Fast Charging/Discharging Lithium Metal Battery
Authors: Zhou Pan , Zhou Haiyu , Xia Yingchun , Feng Qingqing , Kong Xian , Hou Wen‐hui , Ou Yu , Song Xuan , Zhou Hang‐yu , Zhang Weili , Lu Yang , Liu Fengxiang , Cao Qingbin , Liu Hao , Yan Shuaishuai , Liu Kai 
Published: March 2024

AbstractThe electrolytes for lithium metal batteries (LMBs) are plagued by a low Li+ transference number (T+) of conventional lithium salts and inability to form a stable solid electrolyte interphase (SEI). Here, we synthesized a self‐folded lithium salt, lithium 2‐[2‐(2‐methoxy ethoxy)ethoxy]ethanesulfonyl(trifluoromethanesulfonyl) imide (LiETFSI), and comparatively studied with its structure analogue, lithium 1,1,1‐trifluoro‐N‐[2‐[2‐(2‐methoxyethoxy)ethoxy)]ethyl]methanesulfonamide (LiFEA). The special anion chemistry imparts the following new characteristics: i) In both LiFEA and LiETFSI, the ethylene oxide moiety efficiently captures Li+, resulting in a self‐folded structure and high T+ around 0.8. ii) For LiFEA, a Li−N bond (2.069 Å) is revealed by single crystal X‐ray diffraction, indicating that the FEA anion possesses a high donor number (DN) and thus an intensive interphase “self‐cleaning” function for an ultra‐thin and compact SEI. iii) Starting from LiFEA, an electron‐withdrawing sulfone group is introduced near the N atom. The distance of Li−N is tuned from 2.069 Å in LiFEA to 4.367 Å in LiETFSI. This alteration enhances ionic separation, achieves a more balanced DN, and tunes the self‐cleaning intensity for a reinforced SEI. Consequently, the fast charging/discharging capability of LMBs is progressively improved. This rationally tuned anion chemistry reshapes the interactions among Li+, anions, and solvents, presenting new prospects for advanced LMBs.
Targeted Degradation of Cell‐Surface Proteins via Chaperone‐Mediated Autophagy by Using Peptide‐Conjugated Antibodies
Authors: Shao Jinning , Lin Xuefen , Wang Haoting , Zhao Chuhan , Yao Shao Q. , Ge Jingyan , Zeng Su , Qian Linghui 
Published: March 2024

AbstractCell‐surface proteins are important drug targets but historically have posed big challenges for the complete elimination of their functions. Herein, we report antibody–peptide conjugates (Ab‐CMAs) in which a peptide targeting chaperone‐mediated autophagy (CMA) was conjugated with commercially available monoclonal antibodies for specific cell‐surface protein degradation by taking advantage of lysosomal degradation pathways. Unique features of Ab‐CMAs, including cell‐surface receptor‐ and E3 ligase‐independent degradation, feasibility towards different cell‐surface proteins (e.g., epidermal growth factor receptor (EGFR), programmed cell death ligand 1 (PD‐L1), human epidermal growth factor receptor 2 (HER2)) by a simple change of the antibody, and successful tumor inhibition in vivo, make them attractive protein degraders for biomedical research and therapeutic applications. As the first example employing CMA to degrade proteins from the outside in, our findings may also shed new light on CMA, a degradation pathway typically targeting cytosolic proteins.
From Cd(SCN)2(CH4N2S)2 to Cd(SCN)2(C4H6N2)2: Controlling Sulfur Content in Thiocyanate Systems Significantly Improves the Overall Performance of UV Nonlinear Optical Materials
Authors: Kang Yuwei , Yang Can , Gou Jie , Zhu Yaolong , Zhu Qingwen , Xu Weilin , Wu Qi 
Published: March 2024

AbstractCombining a strong second‐order nonlinear optical (NLO) effect (>1×KH2PO4 (KDP)), a large band gap (>4.2 eV), and a moderate birefringence in ultraviolet (UV) NLO crystals remains a formidable challenge. Herein, Cd(SCN)2(C4H6N2)2, the first example of a thiocyanate capable of realizing a phase‐matched UV NLO crystal material, is obtained by reducing the sulfur (S) content in the centrosymmetric (CS) structure of Cd(SCN)2(CH4N2S)2. Compared to the “shoulder‐to‐shoulder” one‐dimensional (1D) chain of Cd(SCN)2(CH4N2S)2, Cd(SCN)2(C4H6N2)2 has a different sawtooth 1D chain structure. Cd(SCN)2(CH4N2S)2 has second harmonic generation (SHG) inertia with a band gap of 3.90 eV and a UV cutoff edge of 342 nm, however, it possesses a large birefringence (0.35@546 nm). In contrast, the symmetry center breaking of Cd(SCN)2(C4H6N2)2 leads to remarkably strong SHG intensity (10 times that of KDP). Furthermore, it has a wide band gap (4.74 eV), short UV cutoff edge (234 nm), and moderate birefringence capable of phase matching (0.17@546 nm). This research indicates that thiocyanates are a promising class of UV NLO crystal materials, and that modulation of the sulfur content of CS thiocyanates is an effective strategy for the development of UV NLO crystals with excellent overall performances.
Asymmetric Synthesis of SCF3‐Substituted Alkylboronates by Copper‐Catalyzed Hydroboration of 1‐Trifluoromethylthioalkenes
Authors: Kojima Yuki , Nishii Yuji , Hirano Koji 
Published: March 2024

AbstractA synthetic method for preparation of optically active trifluoromethylthio (SCF3) compounds by a copper‐catalyzed regio‐ and enantioselective hydroboration of 1‐trifluoromethylthioalkenes with H‐Bpin has been developed. The enantioselective hydrocupration of an in situ generated CuH species and subsequent boration reaction generate a chiral SCF3‐containing alkylboronate, of which Bpin moiety can be further transformed to deliver various optically active SCF3 molecules. Computational studies suggest that the SCF3 group successfully controls the regioselectivity in the reaction.
Heterodyne‐Detected Sum‐Frequency Generation Vibrational Spectroscopy Reveals Aqueous Molecular Structure at the Suspended Graphene/Water Interface
Authors: Wang Yongkang , Tang Fujie , Yu Xiaoqing , Ohto Tatsuhiko , Nagata Yuki , Bonn Mischa 
Published: March 2024

AbstractGraphene, a transparent two‐dimensional conductive material, has brought extensive new perspectives and prospects to various aqueous technological systems, such as desalination membranes, chemical sensors, energy storage, and energy conversion devices. Yet, the molecular‐level details of graphene in contact with aqueous electrolytes, such as water orientation and hydrogen bond structure, remain elusive or controversial. Here, we employ surface‐specific heterodyne‐detected sum‐frequency generation (HD‐SFG) vibrational spectroscopy to re‐examine the water molecular structure at a freely suspended graphene/water interface. We compare the response from the air/graphene/water system to that from the air/water interface. Our results indicate that the
spectrum recorded from the air/graphene/water system arises from the topmost 1–2 water layers in contact with the graphene, with the graphene itself not generating a significant SFG response. Compared to the air/water interface response, the presence of monolayer graphene weakly affects the interfacial water. Graphene weakly affects the dangling O−H group, lowering its frequency through its interaction with the graphene sheet, and has a very small effect on the hydrogen‐bonded O−H group. Molecular dynamics simulations confirm our experimental observation. Our work provides molecular insight into the interfacial structure at a suspended graphene/water interface, relevant to various technological applications of graphene.
Sonocatalysis green synthesis of indeno[1,2‐b]indolone derivatives using CuFe2O4@CS‐SB nanocomposite as a reusable catalyst under mild conditions
Authors: Hassanpour Hannaneh , Naeimi Hossein 
Published: March 2024

In this literature, the synthesis of indeno[1,2‐b]indolone from starting materials of ninhydrin, derivatives of aniline, and dimedone by using copper ferrite anchored to chitosan bearing Schiff base (CuFe2O4@CS‐SB) as a catalyst in water solvent under ultrasound irradiation was described. This catalyst was designed, fabricated, and characterized by the FT‐IR, 1H NMR, XRD, SEM, TGA, mapping scan, EDX, and BET techniques. This prepared acidic, effective heterogeneous catalyst catalyzed green synthesis of indeno‐indolone derivatives in a very short reaction times between 1 and 7 min with excellent yields between 95% and 99%. Also, the FT‐IR, 1H NMR, and melting point analyses are used to identify the synthesis of the indolones as organic products.
Ligand‐field effect to harness the magnetic anisotropy in a series of mixed valence Co (III)–Co (II) dinuclear complexes
Authors: Manohar Ezhava Manu , Guizouarn Thierry , Ahmed Naushad , Herchel Radovan , Pointillart Fabrice , Das Sourav , Dey Atanu 
Published: March 2024

Three mixed valence dinuclear Co (III)–Co (II)‐based complexes having general formulae of [CoIICoIII (HL2)2(L1)] [L1H = 2‐hydroxy‐1‐naphthaldehyde (1), o‐vanillin (2), and salicylaldehyde (3)] have been synthesized successfully using Schiff base (LH4) ligand. The complexes were characterized by single‐crystal XRD, powder XRD, IR, and UV–Vis analyses. The CoII ion with elongated octahedral geometry conferred significant magnetic anisotropy with D values being 64.0(8), 71.1(7), and 52.1(3) cm−1 for 1, 2, and 3, respectively. These complexes exhibited single‐molecule magnet behavior with magnetic relaxation occurring mainly through Raman for 1 and 3 whereas direct and Raman for complex 2. The analysis of the static and dynamic magnetic properties was further supported by theoretical calculations using CASSCF/DLPNO‐NEVPT2.
Flame retarded polyurethane vitrimers containing isocyanurate rings: Synthesis and properties
Authors: Meng Fansen , Yang Yiyin , Shen Kaiwen , Tang Donglin 
Published: March 2024

AbstractIn this study, flame retarded polyurethane vitrimers, namely vitrimeric poly(isocyanurate urethane)s (VPICUs), were synthesized successfully by melting polycondensation simply from tris(2‐hydroxyethyl)isocyanurate and dicarbamates. By increasing the methylene number in dicarbamates from 4 to 10, the VPICUs exhibit superior mechanical performance with elongation at break increases from 20% to 350% while the tensile strength decreases from 80 to 32 MPa, and the toughness can be significantly enhanced from 9 to 90 J/cm3. With a mass fraction of isocyanurate ring at 26.6%, for VPICU10‐2.5/2, the flame retardancy is found to be the most excellent, with a UL‐94 rating at V‐0 and a LOI value at 25.9%. VPICU10 samples exhibit substantial relaxation behavior at higher temperature, and the network rearrangement activated by transesterification and transurethanization reactions offers the reprocessability without losing the properties. This work provides new insights into the construction of sustainable and high‐performance flame retarded polymer materials.
Predicting the tensile and compressive modulus of electrospun fiber mat‐reinforced hydrogels using the Halpin–Tsai equations
Authors: Beckett Laura E. , Lewis Jackson T. , Tonge Theresa K. , Korley LaShanda T. J. 
Published: March 2024

AbstractThe reinforcement of mechanically‐weak hydrogels to yield composites with increased stiffness, strength, or toughness is a well‐established approach. In particular, introducing electrospun nanofibers into hydrogels is a common strategy for biomedical applications, as the resulting hierarchical structure mimics biology and allows for control over fiber diameter and alignment and tuning of mechanical properties. However, further study of the link between the constituent materials and the mechanical properties of the composite is uncommon. One potential model to understand the mechanical properties of fiber‐reinforced hydrogels involves the Halpin–Tsai equations, which relate the modulus values of the fibers and hydrogel matrix and the fiber volume fraction, to the modulus of the composite. To assess the application of this model to fiber‐reinforced hydrogels, predicted values were compared with experimental values from mechanical testing of a poly(ethylene glycol) (PEG) matrix reinforced with an electrospun polycaprolactone (PCL) fiber mat. Although the equations described these systems well in tension, providing a facile approach to identify a fiber volume fraction that will achieve a desired modulus, the Halpin–Tsai approach was less successful under compression. This study motivates additional investigation of the role of structural features of hydrogel composites in determining mechanical properties to enable design of materials for specific applications.
The Radon and Hilbert transforms and their applications to atmospheric waves
Authors: Mayta Víctor C. , Adames Corraliza Ángel F. , Lin Qiao‐Jun 
Published: March 2024

AbstractThe Radon and Hilbert transform and their applications to convectively coupled waves (CCWs) are reviewed. The Hilbert Transform is used to compute the wave envelope, whereas the Radon transform is used to estimate the phase and group velocities of CCWs. Together, they provide an objective method to understand CCW propagation. Results reveal phase speeds and group velocities for fast waves (mixed Rossby‐gravity, westward and eastward inertio‐gravity, and Kelvin) that are consistent with previous studies and with Matsuno's equatorial wave dispersion curves. However, slowly‐propagating tropical depression‐like systems and equatorial Rossby waves exhibit wave envelopes that propagate faster than the individual wave crests, which is not predicted by dry shallow water theory.
Expanding the Massachusetts Birth Defects Monitoring Program to include additional pregnancy outcomes: Programmatic efforts and impacts on case ascertainment, 2012–2020
Authors: Fothergill Amy , Liberman Rebecca F. , Nestoridi Eirini , Mai Cara T. , Yeung Lorraine F. , Higgins Cathleen , Yazdy Mahsa M. 
Published: March 2024

AbstractBackgroundBirth defects affect 1 in 33 infants in the United States and are a leading cause of infant mortality. Birth defects surveillance is crucial for informing public health action. The Massachusetts Birth Defects Monitoring Program (MBDMP) began collecting other pregnancy losses (OPLs) in 2011, including miscarriages (<20 weeks gestation) or elective terminations (any gestational age), in addition to live births and stillbirths (≥20 weeks gestation). We describe programmatic changes for adding OPLs and their impact on prevalence estimates.MethodsUsing population‐based, statewide, data from the MBDMP (2012–2020), we assessed prevalence per 10,000 live births and 95% confidence intervals (CIs) with and without OPLs overall and for specific birth defects by time period, maternal age, and race/ethnicity.ResultsIncluding OPLs required amending a state statute and promulgating regulations, new data sources, and additional data processing, cleaning, and verification. Overall prevalence with OPLs increased from 257.4 (95% CI: 253.5–261.4) to 333.9 (95% CI: 329.4–338.4) per 10,000; increases were observed in all time periods, age, and race/ethnicity groups. After including OPLs, the prevalence increased for neural tube defects [3.2 (2.7–3.6) to 8.3 (7.6–9.0)], and trisomies 13 [0.5 (0.3–0.7) to 4.1 (3.6–4.6)], 18 [1.5 (1.2–1.9) to 8.2 (7.5–8.9)], and 21 [12.3 (11.4–13.2) to 28.9 (27.6–30.2)]. Cardiovascular defects increased slightly, while prevalence of eye/ear, respiratory, and gastrointestinal defects remained similar.ConclusionsAdding OPLs required substantial programmatic efforts and resulted in more complete case ascertainment, particularly for certain birth defects. More complete case ascertainment will allow for improved research, screening, and resource allocation.
High yield sterile filtration process for highly concentrated lentiviral vectors
Authors: Vogel Jessica E. , Terrao Monica , Schwingal Sarah , Kapitza Laura , Brigulla Daniel , Pirzas Vicky , Laux Holger , Brandt Tobias 
Published: March 2024

AbstractThe development and manufacture of biopharmaceuticals are subject to strict regulations that specify the required minimum quality of the products. A key measure to meet these quality requirements is the integration of a sterile filtration step into the commercial manufacturing process. Whereas common procedures for most biologics exist, this is challenging for lentiviral vector (LVV) production for ex vivo gene therapy. LVVs nominal size is more than half the pore size (0.2 µm) of filters used for sterile filtration. Hence, highly concentrated virus solutions are prone to filter clogging if aggregation of viruses occurs or impurities attach to the viruses. Several filters were screened aiming to identify those which allow filtering highly concentrated stocks of LVVs of up to 1E + 9 transducing units mL−1, which corresponds to 4.5E + 12 particles mL−1. In addition, the effect of endonuclease treatment upstream of the purification process on filter performance was studied. In summary, three suitable filters were identified in a small‐scale study (<15 mL) with virus yields >80% and the process was successfully scaled‐up to a final scale of 100 mL LVV stock solution.