bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of pupil expansion devices in small pupil phacoemulsification
Authors: Potti Sudhakar , Reddy Sodum Nivedita 
Published: February 2024

Purpose:
To study the outcomes of phacoemulsification in small pupils (≤4 mm) using pupil expansion devices at a tertiary eye care center in South India.

Methods:
The study design is prospective, randomized, comparative, and interventional. Mechanical pupil dilatation with iris retractors (group I), B-HEX ring (group II), and Gupta ring (group III) was compared with respect to pupil size achieved (intraoperative), total surgical time, device addition time, complications, endothelial cell loss, and postoperative best corrected visual acuity.

Results:
Among 36 participants (12 in each group), the mean pupil size, total surgical time, and device addition time were maximum with iris retractors. Intraoperatively, sphincter tear was seen in two eyes in the iris retractors group and one eye in the Gupta ring group. In the B-HEX ring group, only two flanges of the ring could be engaged in two participants, one patient had iris bleeding (during stretching of the iris), and one patient had anterior lens capsular tear. Among all three groups, there was no statistically significant difference in best corrected visual acuity (BCVA), endothelial cell count, and coefficient of variation obtained in the preoperative period, postoperative Day 7 and Day 30, respectively.

Conclusion:
In our study, in more than 50% of cases, the cause of small pupil was idiopathic/senile. Among nonidiopathic causes, PXF was the most common association. Although iris retractors are cost-effective and give maximum intraoperative dilatation, there is a need of four additional side ports to be made, thus increasing the total surgical time and device addition time. On the other hand, B-HEX and Gupta ring provide comparable intraoperative dilation and device addition time and also have comparable postoperative outcomes in terms of postoperative pupil size and complications.
A Narrative Review on Dengue and COVID-19 Co-infection: A Deadly Duo
Authors: Kumar Santosh , Mishra Ashutosh 
Published: February 2024

Abstract
The ongoing COVID-19 pandemic in dengue-endemic countries falls as a huge burden on healthcare infrastructure. Above everything, similar signs and symptoms of diseases caused by the two viruses make diagnosis and treatment more difficult. For this literature review, published articles from January 2020 to March 2023 available in the databases ‘PubMed’, ‘Google Scholar’ and ‘Embase’ have been explored to look at the similarities and differences between dengue and SARS-CoV-2 virus through the lens of genomics, epidemiology, clinical presentation and outcome of patients. The objectives of this study were to draw conclusions about the proposed pathophysiology of the viruses in case of a co-infection and to narrate evidence on outcome associated with the co-infection. Co-infection with dengue and COVID-19 virus can lead to moderate-to-severe morbid conditions; even the outcome could be fatal due to shock, multi-organ failure and stroke.
Effectiveness of PD1/PD-L1 combined with anti-angiogenic drugs in patients with advanced nonsmall cell lung cancer: A systematic review and meta-analysis
Authors: Duan Xueyu , Liu Xiaobo , Chen Ruixiang , Pu Yanjiao 
Published: February 2024

Background:
Protein-1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1) therapy have become an important treatment approach for patients with advanced nonsmall cell lung cancer (NSCLC), but primary or secondary resistance remains a challenge for some patients. PD-1/PD-L1 combined with anti-angiogenic drugs (AAs) in NSCLC patients have potential synergistic effects, and the survival benefit may vary based on a treatment order. To investigate the efficacy of PD-1/PD-L1 combined with AAs as the treatment for patients with advanced NSCLC.

Materials and Methods:
We comprehensively searched EMBASE, PubMed, Web of Science, CNKI, VIP, and Wanfang databases from January 2017 to September 2022. The Cochrane risk bias tool evaluated the quality of included randomized clinical trials. Newcastle-Ottawa-Scale score was used to evaluate the quality of retrospective studies. Publication bias was evaluated by funnel plot, Begg’s test, and Egger’s test.

Results:
Seventeen articles were finally selected, involving 5182 patients. Meta-analysis results showed that PD1/PD-L1 combined with AAs therapy significantly improved progression-free survival (PFS) (hazard ratio [HR] = 0.61, 95% confidence interval [CI]: 0.50–0.75, P < 0.00001), overall survival (OS) (HR = 0.79, 95% CI: 0.71–0.88, P < 0.00001), and objective response rate (ORR) (risk ratio = 0.88, 95% CI: 0.81–0.96, P = 0.004), with the statistically significant difference. The sensitivity analysis demonstrated the robustness of the PFS, ORR, and OS.

Conclusion:
The combination of PD-1/PD-L1 inhibitors with AAs in treating advanced patients has exhibited notable therapeutic advantages when contrasted with monotherapy. Specifically, the administration of PD-1/PD-L1 inhibitors in conjunction with AAs, or sequential treatment involving PD-1/PD-L1 followed by AAs, has shown enhanced therapeutic efficacy in this patient population.
Safety and efficacy of a polyherbal formulation from traditional Persian medicine in patients with calcium kidney stones: A randomized, double-blinded clinical trial
Authors: Ansari Ramin , Karimzade Iman , Nimrouzi Majid , Ezatzadegan Shahrokh , Hosseini Mohammad Mehdi , Zarshenas Mohammad Mehdi 
Published: February 2024

Background:
10%–15% of the world’s population suffers from kidney stones. Nearly 50% increase was observed in diagnosing and treating nephrolithiasis in the last decades. Effective medical treatment for the disease is not yet well established. Moreover, there is an increasing global demand to manage diseases using complementary and alternative medicine. This study aimed to formulate and assess the safety and efficacy of a multi-ingredient formulation from traditional Persian medicine (TPM) known as Mofatet powder in patients suffering from calcium kidney stones.

Materials and Methods:
The aqueous extract of Mofatet powder was prepared, freeze-dried, and formulated as capsules. 26 patients in the drug group and 25 patients in the placebo group used 500 mg capsules of the drug/placebo twice daily for 5 weeks. Ultrasonography/kidney, ureter and bladder imaging, urine analysis, and biochemical parameters were evaluated before and after the intervention.

Results:
The imaging results showed a 60.73% decrease (P < 0.001) in stone size in the drug group. Moreover, the urinary calcium decreased (P = 0.02) and the urinary magnesium increased (P < 0.001) in the drug group. No remarkable changes were observed in the placebo group in these parameters. No significant effect was observed in aspartate transaminase, alanine transaminase, serum creatinine, and blood urea nitrogen levels in none of the groups.

Conclusion:
This study suggests that Mofatet powder was effective in reducing calcium kidney stones size with no potential nephro/hepatotoxicity. After confirming these results in larger clinical trials with longer duration, this formulation can be considered a treatment for nephrolithiasis.
The Incidence, Risk, and Overall Survival of First and Second Primary Head and Neck Malignancies in the Eastern Province, Saudi Arabia
Authors: Alghuneem Aishah Adnan , AlRusayyis Danah Fahad , Alabdulwahid Fatmah Abdullah , Saud Ijaz Ahmed , Al-Assiry Mansour Ahmed , Salam Abdul , Almuhaimid Turki Mohammed 
Published: February 2024

Abstract

Background:
The mean survival time of head and neck cancers (HNC) differs according to patient and tumor characteristics. Treatment with radiotherapy or chemotherapy, genetic susceptibility, and environmental factors can contribute to the risk of developing second primary malignancy (SPM).

Objective:
Our purpose is to determine the rate of first primary malignancy and SPM among HNC patients, identify risk factors that may lead to the development of SPM, and analyze predictors of overall survival.

Subjects and Methods:
This is a single-center, retrospective study that included patients who were diagnosed with a head and neck and nonhead and neck SPM and visited the head and neck clinic between 2010 and 2020. Patients diagnosed with thyroid cancer or head and neck lymphoma, treated outside the facility, or lost to follow-up were excluded from the study. Data about demographics, diagnosis-related information, therapeutic approach, tumor recurrence, and the status of the patient and the tumor after the latest hospital visit were collected.

Results:
Thirty-seven (6.13%) cases were diagnosed with SPM with a median age of 61 years and a median time to diagnosis of 30.1 months from the first malignancy. Nearly half of the SPM patients were males (54.05%), smokers (51.35%), and underwent radiotherapy to treat the first cancer (51.35%). Laryngeal cancer carries the highest risk of the development of SPM of all SPM cases, followed by oral cavity cancers. The overall survival in patients with metachronous SPM is better than synchronous malignancies, with a median survival time of 149 months.

Conclusion:
The development of an SPM in patients with HNC is associated with decreased overall survival. Male gender, hypertension, and primary cancer site were significant risk factors for SPM.
PENYELESAIAN KASUS PENYEROBOTAN TANAH MELALUI ASPEK HUKUM ACARA PIDANA
Authors: Deshaini Liza , Aryadi Fitra , Alem M. Zafri , Susanti Eva , Siregar Badai Baras 
Published: February 2024

Abstrak
Penyerobotan tanah bukan merupakan suatu hal yang baru di berbagai daerah di Indonesia. Secara umum istilah penyerobotan tanah dapat diartikan sebagai perbuatan menguasai, menduduki, atau mengambil alih tanah milik orang lain secara melawan hukum. faktor-faktor penyebab terjadinya penyerobotan tanah hak milik adalah sebagai berikut: Sifat tamak atau rakus manusia, Faktor Ekonomi, Faktor Pekerjaan, Faktor Pendidikan. Penyelesaian kasus penyerobotan tanah dalam Hukum Acara Pidana. Adapun tahapan proses penyelesaian kasus penyerobotan tanah dalam Hukum Acara Pidana adalah sebagai berikut: Adanya laporan atau pengaduan, Pelimpahan perkara kepada jaksa penuntut umum, Penuntutan, dakwaan, Pemeriksaan pengadilan, Pembacaan Surat Dakwaan, Eksepsi, Pemeriksaan alat-alat bukti, Penuntutan, Pembelaan Replik, Duplik, Putusan hakim, Upaya Hukum Biasa dan Upaya Hukum Luar Biasa.
Kata Kunci : Penyerobotan Tanah, Aspek Hukum, Acara Pidana
ANALISIS YURIDIS RESTORATIVE JUSTICE DALAM KEPASTIAN HUKUM TERHADAP ANAK PELAKU TINDAK PIDANA
Authors: Melati Annisa Fitri Arrum , Syawaludin Syawaludin , Utoyo Marsudi 
Published: February 2024

Abstract
Restorative Justice is an approach to justice that focuses on the needs of victims and perpetrators of crime, and involves community participation, rather than implementing the principle of punishing perpetrators accompanied by the judge's considerations. Crimes committed by children are basically inseparable from various life pressures, both economic and social. As a result, quite a few children become perpetrators of crimes or crimes. This research uses a Normative Juridical research method using a statutory approach, a case approach and a conceptual approach. For children's cases, diversion must be carried out in every examination of children's cases from investigation, prosecution to examination at trial, taking into account: the category of crime, the age of the child, the results of social research from the father, the support of the family and community environment. The judge's authority is to examine and decide on children's cases at the first level with a single judge and as a facilitator in diversion. The advice that can be given is that children who commit crimes must still receive protection in the juvenile criminal justice system. One of them is implementing restorative justice using the diversion method, and judges who have the authority to examine and decide on children's cases must be proactive in encouraging restorative justice using the diversion method.
Keyword : Restorative Justice, Juvenile Crimes, Judge’s Authority, Diversion
YEREMYA KİTABI’NIN İÇERİK BAĞLAMINDA DEĞERLENDİRİLMESİ
Authors: Ersözlü Fatma 
Published: February 2024

Yeremya peygamber, Babil sürgünü döneminde Yahuda topraklarında yaşamış ve sürgüne şahit olmuştur. Yeremya, peygamberliği süresince Yahve’nin Musa ile yaptığı Sina ahdinden uzaklaşmış olan İsrailoğullarını, ahit şartlarına uymaya çağırmış ve bu isyanlarında devam etmeleri halinde yaklaşan sonu haber vermiştir. Tanah’ta anlatılan İsrailoğullarının tarihi; Yahve’ye isyan, ilahî gazap, yıkım, sürgün ve dönüş üzerine bir döngü halinde tekrarlamaktadır. Yeremya döneminde yaşananlar ile ilgili peygamberin bildirisi de bu sıralamayı takip etmiştir.
Babil sürgününe gidiş sürecini anlatan Yeremya Kitabı’nda, Yahve’nin On Emir’de bildirdiği “Benim önümde başka ilahlarınız olmayacak” emrine itaat etmeyen ve başka milletlerin ilahlarına yönelen halkı bekleyen yıkım ve sürgün anlatılmaktadır. Yeremya, belirli bir zaman süreceğini bildirdiği sürgünden sonra Yahve’nin İsrailoğullarına duyduğu sevgi nedeniyle yeniden onları Kudüs’te toplayacağı müjdesini vermektedir. Bu makalede, Yeremya Kitabı’nın konu başlıkları, teması ve Tanah’ta özellikle bu kitapta yer alan kelimeler üzerinden tahlil edilecektir.
Yoshlarning oilaviy hayot haqidagi tushunchalarini psixologik bilimlar bilan shakllantirish
Authors: Nurmatova Mamlakatxon 
Published: February 2024

Ushbu maqolada yoshlarning oilaviy va nikohga oid bilimlarini shakllantirishda salbiy psixologik holatlarning oldini olish uchun psixologik bilimlarning zarurligi haqida ilmiy bilimlar ifodalangan, shuningdek, yoshlarda oilaviy munosabatlardagi muvozanatni to‘g‘ri tashkil etish haqidagi bilimlar yoritilgan.
O‘zbek bolalar musiqiy o‘yin folklorining mavzuviy tasnifi
Authors: Rajabov To‘xtasin 
Published: February 2024

Ushbu maqolada o‘zbek bolalar folklorining mavzuviy tasnifi haqida fikr yuritilgan. O‘yinlarning g‘oyaviy mundarijasi keng yoritilgan. Shuningdek, bolalar musiqiy o‘yinlarining maqsad va vazifalari 3 turga ajratilganligi haqida ma’lumot berilgan.
Ключевые особенности исторического развития административных процедур на территории Республики Узбекистан
Authors: Нормухамедова Сурайёхон 
Published: February 2024

Данная статья посвящена изучению административных процедур на территории Средней Азии. Автор сосредотачивает свое внимание на изучении исторических аспектов административных процедур, что способствовало изучению не только появления административных процедур, но и выявлению факторов, повлиявших на развитие и становление административных процедур как ключевого административно-правового института, логически вписавшегося в структуру административно-правового регулирования. История, являясь своего рода «точкой отсчета», объединяет нации, народности. История учит с пониманием относиться ко времени, анализировать сложные ситуации со множеством обстоятельств. Посредством данной публикации автор доносит до читателя необходимость изучения генезиса административных процедур, поскольку именно «обращение к истории» позволяет детально изучить ошибки прошлого, способствующих совершенствованию нашего настоящего и будущего. Целью данной публикации является изучение поэтапного становления административных процедур в Республике Узбекистан, путём рассмотрения теоретических проблем периодизации. Данная публикация – попытки детального формирования представлений о возникновении административных процедур в Республике Узбекистан. С помощью настоящей публикации автор доносит до читателей, что дошедшим до наших дней административным процедурам, мир не обязан исключительно западноевропейским странам. Зачатки становления административных процедур имелись и на территории Средней Азии, но изучению которых должного внимания не придавалось. При написании данной статьи были использованы законодательные источники, делопроизводственная документация, Директивные решения Национального архива Республики Узбекистан, а также были применены материалы, находящиеся в свободном доступе Интернет.
Анжирота петроглифлари
Authors: Ойназаров Холиёр 
Published: February 2024

Мазкур мақолада 2021-2022 йилларда Ўзбекистоннинг жанубий ҳудудларида олиб борилган тадқиқотлар натижасида бир қанча петроглифлар аниқланганлиги ҳамда уларнинг мазмун-моҳияти, ишланиш техникаси, қиёсий таҳлили ва хронологияси ҳақида сўз боради
Фарғона вилоятида пахтачиликнинг ривожланиши тарихининг архив ҳужжатларида ёритилиши (мустамлака даври мисолида)
Authors: Мирзаев Авазбек 
Published: February 2024

Ушбу мақолада мустамлака даврида Фарғона вилоятида пахтачиликнинг ривожланиши тарихининг баъзи масалалари архив ҳужжатлари асосида манбашунослик нуқтаи назаридан таҳлил этилган.
Takomillashgan mehnat kodeksi
Authors: Khajiev Azizbek , Norkulova Mukaddas 
Published: February 2024

Mazkur maqolada 2022-yil 28-oktabr kuni qabul qilingan va joriy yilning 30-aprel sanasidan kuchga kirishi kutilayotgan yangi tahrirdagi Mehnat kodeksining avvalgi Mehnat kodeksidan farqli tomonlari haqida so‘z yuritiladi.
Жисмоний фаолликнинг физиологик-биологик, ижтимоий ва педагогик жиҳатлари
Authors: Жўраев Бобомурод 
Published: February 2024

Ушбу мақолада жисмоний фаолликнинг физиологик-биологик, ижтимоий ва педагогик жиҳатларининг қатор омиллари, миллий маънавий меросимизда қайд этиб ўтилган насиҳат ва йўриқларнинг тўғри эканлиги илмий адабиётлардаги маълумотлар ёрдамида таҳлил қилинган.
Exploring the internal quality assurance management practices at the University of Ghana
Authors: Boateng Fred Kofi , Anyidoho Emmanuel Dodzi , Fletcher Jonathan , Intsiful Emmanuel , Sarpong Joshua 
Published: February 2024

There is a dearth in literature on how quality assurance actors perceive the effectiveness of their own approaches to internal quality assurance practices in Ghana’s tertiary education system. This study, with the systems model as an analytical construct, used a constructivist-interpretivist approach to explore the internal quality assurance management practices at the University of Ghana. Semi-structured interviews and document analysis were used to gather data from the University of Ghana (UG). The themes that emerged from the data indicated that UG has a comprehensive quality assurance policy, policy implementation structure and quality assurance management system. The results show that there is lack of well–resourced quality assurance offices at the policy implementation staircases, inadequate quality assurance stakeholders’ involvement and neglect of quality assurance measures for educational outcome sub-system. The results imply that for UG to improve on its internal quality assurance management there is a need to establish well-resourced quality assurance offices at the policy implementation staircases. In addition, quality assurance actors should involve all stakeholders stipulated in the quality assurance policy documents.
Management of higher educational institutions in Ghana amid COVID-19 pandemic: The case of University of Cape Coast
Authors: Ghartey Alfred , Dankwa Julia , Owusu Rebecca 
Published: February 2024

Aptly described as the biggest challenge to have confronted humanity since World War II, the COVID-19 pandemic has caused major damage in all spheres of life. Using Mitroff’s (2005) Crises Management Model, this paper focuses on higher education institutions and investigates how the senior management of a typical African higher education institution reacted to the pandemic. Deploying the qualitative case study approach with a phenomenological transcendental design, the study sought to explore the challenges the University of Cape Coast Management faced and the measures it adopted to manage the pandemic. The participants were comprised of seven management members. It was found that the university was not prepared for a pandemic of this nature. The study also found that the pandemic posed key challenges, namely, administrative, financial, and operational. Nonetheless, the university instituted some coping mechanisms that helped mitigate the impact of the pandemic. It is recommended that the university develop a comprehensive crisis response plan that provides standard operational guidelines regarding administrative work and teaching and also protocols for reducing the spread of infections. The paper proposes that the university create an emergency fund and build the capacity of its members to adopt appropriate technology to enhance teaching, learning, and administrative work.
PERAN DATA STORE DALAM MEMPRESENTASIKAN HUBUNGAN DATA FLOW DIAGRAM SSADM DENGAN ENTITY RELATIONSHIP DIAGRAM
Authors: Rizki Ridwan  , Nunu Kustian  , Erlin Windia Ambarsari  
Published: February 2024

The information system development step often used is the System Development Life Cycle (SDLC). One of the SDLC stages is system design. It uses the Data Flow Diagram version of the Structured System Analysis and Design Methodology (SSADM) because it is a traditional model closely related to the waterfall model. This study aims to prove the role of the data store in the DFD and become an entity in the Entity-Relationship Diagram (ERD) to see the relationship between each entity. Benefit the associative method tests the connection of the data store on the DFD, which is realized to the ERD. The results obtained are the role of the data store in the DFD to become an entity on the ERD with a proven query table to facilitate data retrieval.
Keywords: Entity Relationship Diagram, Data Flow Diagram, SDLC, SSADM
Analisis Pengendalian Kualitas Pada Pengolah Minyak Kelapa Sawit Dengan Metode Six Sigma Pada PT Suryabumi Agrolanggeng
Authors: Rismantia Putri , Widya Setiafindar  
Published: February 2024

PT SURYABUMI AGROLANGGENG is a company engaged in the plantation and palm oil processing industry. The problem that occurs in the company is the occurrence of defects in CPO oil in the form of defects in the raw material, namely FFB (Fresh Fruit Bunches), where the defects consist of F00, F0, and F5 defects with large defects, namely 28.16% FFB with fraction 0, then there are 12.07% FFB with a fraction of 00, and there are as many as 18.63% FFB with a fraction 5. From the problems and conditions that occur in the company, quality control can be carried out. One of the quality control techniques is using the six sigma method.
Six sigma method is a statistical concept that measures a process related to defects at the level of six (Six) sigma. Six sigma focuses on eliminating defects by emphasizing understanding, measuring, and improving processes. In six sigma there are 5 phase cycles namely Define, Measure, Analyze, Improve, and Control
Based on the results of data processing, it is known that the most dominant type of defect is Fraction 0 of 47.4%, from analysis using a fishbone diagram there are 4 factors causing defects, namely human, material, machine, and environmental factors. The improvement solutions obtained are conducting training, increasing work motivation with rewards, designing sorting aids using automatic technology, tightening and increasing supervision during harvesting, paying attention to lighting needs, implementing 5 S, monitoring production room temperature regularly, conducting trials. the machine before being used for the production process, replace the old pipe or sludge tank with a new one.