bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deciphering the Influence of Socioeconomic Status on Brain Structure: Insights from Mendelian Randomization
Authors: Xia Charley , Lu Yuechen , Zhou Zhuzhuoyu , Marchi Mattia , Kweon Hyeokmoon , Ning Yuchen , Liewald David C. M. , Anderson Emma L. , Koellinger Philipp D. , Cox Simon R. , Boks Marco P. , Hill W. David 
Published: March 2024

AbstractSocioeconomic status (SES) influences physical and mental health, however its relation with brain structure is less well documented. Here, we examine the role of SES on brain structure using Mendelian randomisation. First, we conduct a multivariate genome-wide association study of SES using individual, household, and area-based measures of SES, with an effective sample size of n=893,604. We identify 469 loci associated with SES and distil these loci into those that are common across measures of SES and those specific to each indicator. Second, using an independent sample of ∼35,000 we provide evidence to suggest that total brain volume is a causal factor in higher SES, and that SES is protective against white matter hyperintensities as a proportion of intracranial volume (WMHicv). Third, we find evidence that whilst differences in cognitive ability explain some of the causal effect of SES on WMHicv, differences in SES still afford a protective effect against WMHicv, independent of that made by cognitive ability.
Novel, postnatal manifestation of an epidermal barrier defect in a mouse model of isolated sulfite oxidase deficiency
Authors: Johannes Lena , Rübsam Matthias , Löhr Julia , Ding Xiaolei , Eming Sabine , Niessen Carien M. , Schwarz Günter 
Published: March 2024

AbstractSulfite oxidase deficiency is a rare inborn error in metabolism leading to early childhood death due to rapidly progressing neurodegeneration. A new mouse model of sulfite oxidase deficiency carrying a homozygous deletion in theSuoxgene resembles the human pathology in terms of neonatal death and elevation of sulfite and thiosulfate in plasma and urine, respectively. HomozygousSuox-/-mice are initially born healthy, display growth retardation starting at postnatal day 4 and die in average at day 9.6. Here we report thatSuox-/-mice develop dry and scaly skin early postnatally, showing that sulfite oxidase is essential to maintain a functional skin barrier after birth. At postnatal day 5Suox-/-mice develop altered epidermal morphology and dysregulated early and late keratinocyte differentiation accompanied by increased stress response. We propose a sulfite-induced cleavage of disulfide bonds in key epidermal proteins essential for a functional barrier.
Map based cloning ofCT2and the pilot functional exploration in abiotic stress
Authors: Wang Chen , Zheng Qi , Xianggao Yi , Guo Zhanyong , Zheng Lanjie , Yang Jianping , Tang Jihua , Jin Weihuan , Zheng Xu , Shi Yong 
Published: March 2024

AbstractHeterotrimeric G-proteins are multifunctional modulators that participate in a wide range of growth and developmental processes in eukaryotic species, from yeast to plants and animals. Component detection and the study of G protein signaling in most plants, including maize, are in the initial stages. In this study, we characterized a maize mutant,ct2, that showed a compact architecture and reproductive organ-related phenotypic variation. The target geneCT2was cloned using bulked segregant analysis and map-based cloning. Gene structure prediction and phylogenetic analysis indicated thatCT2is a canonical Gα protein belonging to the monocotyledonous group. Promoter analysis ofCT2and RNA sequencing revealedcis-acting regulatory elements and differentially expressed genes involved in JA signaling and stress tolerance. The transcription ofCT2was repressed by NaCl and PEG treatments, andct2mutation in thect2line compromised stress tolerance in maize. On the basis of our results, we proposed a schema diagram ofCT2-regulated biological process and their feedback onCT2transcription. This research provides clues for further studies ofCT2function in hormone signaling and stress tolerance, which is beneficial for maize breeding through the screening and application of beneficial alleles.
ANKRD55 interacts with an IFT-B-like complex in microglia
Authors: Mena Jorge , Navarro Raquel Tulloch , Díez-García Javier , Azkargorta Mikel , Aldekoa Ane , Fiat Ainhoa , Ugidos-Damboriena Nerea , Lindskog Cecilia , Pampliega Olatz , Alloza Iraide , Katoh Yohei , Nakayama Kazuhisha , Elortza Felix , Vandenbroeck Koen 
Published: March 2024

AbstractIntroductionSNPs associated with genome-wide risk for multiple sclerosis (MS) modulate expression of ankyrin repeat domain protein 55 (ANKRD55). The function of ANKRD55 is not well understood. A role for ANKRD55 in ciliar transport in multiciliated cells has been reported. To gain deeper insight in how ANKRD55 may modulate neuro-inflammatory parameters, we identified the ANKRD55 interactomes from human neuroblastoma, astrocytic, microglial and monocytic cell lines.MethodsCell lines were transfected with synthetic ANKRD55 RNA in conjunction with nanoparticles. ANKRD55 interactomes were determined by affinity purification coupled to mass spectrometry (AP-MS) and analyzed bioinformatically. Results were validated and interpreted using confocal immunofluorescence microscopy, RNAseq transcriptomics, and a visible immunoprecipitation assay (VIP).ResultsShared among the interactomes were the 14-3-3 isoforms 14-3-3η and 14-3-3βη. Unique to the microglial interactome were eight proteins belonging to the intraflagellar transport complex B (IFT-B). The IFT-B complex is known to mediate anterograde protein trafficking from the base to the tip of cilia. The dimer IFT46-IFT56 was identified as the minimum entity of IFT-B needed to support interaction with ANKRD55. To verify whether ANKRD55 is a ciliar transport protein, we induced ciliogenesis by serum starvation. Primary ARL13B+cilia could be induced in the astrocytic and neuroblastoma, but not microglial, cell lines. By confocal microscopy, ANKRD55 was not detectable in these cilia but was enriched at the basal body. In the microglial cell line, ANKRD55 and IFT-B components were enriched at the centrosome. In two human primary myeloid cell models, monocyte-derived microglia (MoMG) and monocyte-derived dendritic cells (MoDC), we were able to recapitulate the co-localization of ANKRD55 and IFT81 at the centrosome.DiscussionOur work shows that an ANKRD55 – IFT-B-like complex is assembled in microglial cells. Together with the finding that ANKRD55 was not detected in primary cilia, the results suggest that ANKRD55 is associated with an IFT-B pathway that can operate independent of ciliogenesis.
Crosstalk between thrombospondin-1 and CD36 modulates platelet–RBC interaction limiting thrombosis and abdominal aneurysm formation
Authors: Krott Kim Jürgen , Feige Tobias , Bosbach Agnes , Krüger Irena , Pfeiler Susanne , Beele Alicia Noeme , Reusswig Friedrich , Schickentanz-Dey Elena , Chadt Alexandra , Kelm Malte , Gerdes Norbert , Jurk Kerstin , Kiouptsi Klytaimnistra , Reinhardt Christoph , Al-Hasani Hadi , Kehrel Beate E. , Karray Saoussen , Schelzig Hubert , Wagenhäuser Markus Udo , Elvers Margitta 
Published: March 2024

ABSTRACTRed blood cells (RBCs) contribute to hemostasis and thrombosis by interaction with platelets via the FasL–FasR pathway to induce procoagulant activity and thrombin formation. Here, we identified a novel mechanism of platelet-RBC interaction via the CD36–thrombospondin-1 (TSP-1) signaling pathway, which is important in thrombus formation and the recruitment of RBCs to collagen-adherent platelets. Platelet-released TSP-1 can bind to CD36 at the RBC membrane to enhance procoagulant activity and to increase the activation of integrin αIIbβ3, which represents an additional ligand for erythroid FasR, suggesting that both mechanisms of platelet–RBC interaction act in concert to propagate thrombus formation. In patients with abdominal aortic aneurysm (AAA), enhanced procoagulant activity of RBCs and platelets is accompanied by elevated exposure of TSP-1 and FasL at the platelet surface and accumulation of TSP-1 in the aortic wall and the intraluminal thrombus, suggesting that platelet–RBC interaction plays an important role in AAA pathology. TSP-1-deficient mice are protected against aortic diameter expansion in an experimental model of AAA, highlighting the crucial role of the CD36–TSP-1 axis in AAA. Thus, interfering with platelet–RBC interaction may be a promising therapeutic approach to reduce pro-coagulant activity and preserve AAA patients from surgery or rupture.
The influence of individual and contextual factors on proactivity and proficiency: the roles of meaningfulness of work and competitive intensity
Authors: Carballo-Penela Adolfo , Ruzo-Sanmartín Emilio , Bande Belén 
Published: March 2024

PurposeThis article aims to provide knowledge on the antecedents and consequences of individual proactive behaviour. The proposed research model includes two unexplored antecedents (experienced meaningfulness of work and industry competitive intensity) and one consequence (individual proficiency).Design/methodology/approachData were collected from 297 salespeople working at 105 enterprises in a range of industries. Data analysis was performed by applying confirmatory factor analysis and structural equation modelling.FindingsThe results show (1) a positive association between industry competitive intensity and salespeople’s experienced meaningfulness of work and their proactivity at work; (2) a positive relationship between salespeople’s proactive behaviour and their individual proficiency and (3) that salespeople’s proactivity mediates the relation between industry competitive intensity and the experienced meaningfulness of work and individual proficiency.Originality/valueThe results suggest that managers could stimulate proactive behaviour by increasing the experienced meaningfulness of work. They also indicate that it is not only individual factors that are relevant in stimulating proactive behaviour at work, as contextual factors (particularly external ones) can also influence individual decisions with regard to engaging or not in proactive behaviour. Our findings regarding the positive relationship between proactivity and proficiency would help managers to encourage salespeople’s proactive behaviour.
From Allston to Ahmedabad: American hegemony in management education reexamined
Authors: Krishnamurty Keshav 
Published: March 2024

Purpose
This paper aims to study the origin story of Harvard Business School’s involvement with the Indian Institute of Management Ahmedabad to study the reasons for the spread of American management education. It introduces both the explicit influence of Cold War politics and Indian development imaginaries to the export of American management thought in the early 1960s.

Design/methodology/approach
This paper relies on archival research for its primary source material, drawing upon rich archives of documents found at the Baker Library of Harvard Business School.

Findings
Harvard’s role in Ahmedabad was explicitly influenced by the Cold War anti-communist foreign policy of the USA, but did so opportunistically and contrary to the Ford Foundation’s (FF) original plans. Vikram Sarabhai, who was a key player in the Indian national imaginary of development, invited Harvard on his own initiative and forced the foundation to follow his interests rather than being a mere “subaltern.”

Research limitations/implications
This paper could additionally add to the historical debate about the scope and periodization of the Cold War and the role of non-state actors.

Originality/value
This paper covers new ground in exploring the early connection between the Indian development imaginary and business education. It concludes that the export of hegemonic US management education was not successful during Cold War, and the FF was not as dominant as it was made out to be.
Examining tourists' risk-related hesitation and confidence effects on developing distress and associated behavioral responses during COVID-19
Authors: Hameed Rizwana , Akhtar Naeem , Sharma Anshuman 
Published: March 2024

PurposeUtilizing the theoretical foundation of the stimulus-organism-response framework, the present work developed and investigated a conceptual model. The work explores the effects of perceived risk of COVID-19 on tourists' choice hesitation and choice confidence. Furthermore, it examines the impacts of choice hesitation and choice confidence on psychological distress, which, in turn, influences purchase intentions and risk-protective behavior. Additionally, the study assesses the boundary effects of vulnerability on the association between choice hesitation, choice confidence, and psychological distress.Design/methodology/approachAn online survey was administered in China during COVID-19 to assess the postulated hypotheses. We collected 491 responses using purposive sampling, and covariance-based structural equation modeling (CB-SEM) was performed to investigate the relationships.FindingsResults show that the perceived risk of COVID-19 positively influences the choice hesitation and negatively impact choice confidence. It was also found that choice hesitation and choice confidence positively developed psychological distress, which, in turn, negatively triggered purchase intentions and positively developed risk-protective behavior. Additionally, perceived vulnerability had a significant moderating impact on the proposed relationships, strengthening psychological distress.Originality/valueIn the current context, this study measures bipolar behavioral outcomes using the S-O-R model. Because cognitive processes influence participation in health preventative behavior during the spread of diseases, we highlighted how the perception of risk and vulnerability to a pandemic serves as a reliable indicator of certain behaviors. This study advances understanding of how the psychological mindset of tourists copes with such circumstances. Due to the pandemic, tourists face limitations in their choices and are placing greater emphasis on adopting protective measures to mitigate associated risks.
Opportunities and challenges facing LGBTQ+ people in employment in rural England post-pandemic: a thematic analysis
Authors: Pipkin Alastair , Rodriguez Forero Luz Helena 
Published: March 2024

PurposeThe following study aimed to better understand rural dwelling LGBTQ+ adults’ experiences of the challenges and opportunities facing their working lives in England.Design/methodology/approachA qualitative, focus group design was utilized, using online recruitment and an online, one-off focus group. Data were analyzed using thematic analysis.FindingsThree themes were identified: stressors facing LGBTQ+ people in the workplace; opportunities in employment; and ideas to improve the workplace for LGBTQ+ people. Participants spoke to the ways in which both rural living and the pandemic had impacted their working lives, including elevated fears of being discriminated against; experiencing microaggressions in the workplace which they felt were partly elevated by a lack of visibility and affirmative policies; and a sense that specific workplaces inhabited by LGBTQ+ people had been decimated by the pandemic. Conversely, participants spoke of opportunities for affirmation of their gender and/or sexual orientation identities, feeling a sense of pride and connection with their communities through work.Originality/valueThis is the first study to the authors’ knowledge that specifically explores rural dwelling LGBTQ+ adults’ experiences of the workplace post-pandemic. It builds on previous empirical research by highlighting qualitative experiences of challenges and opportunity, which can inform organizations and policymakers’ efforts to promote inclusivity.
Building capacity in urban schools: emphasizing partnerships between counselor education and elementary schools
Authors: Frank Alexandra , Taylor Dalena Dillman 
Published: March 2024

PurposePost-COVID-19, public K–12 schools are still facing the consequences of the years of interrupted learning. Schools serving minoritized students are particularly at risk for facing challenges with academics, behavior and student social emotional health. The university counseling programs are in positions to build capacity in urban schools while also supporting counselors-in-training through service-learning opportunities.Design/methodology/approachThe following conceptual manuscript demonstrates how counselor education counseling programs and public schools can harness the capacity-building benefits of university–school partnerships. While prevalent in fields like special education, counselor educators have yet to heed the hall to participate in mutually beneficial partnership programs.FindingsUsing the multi-tiered systems of support (MTSS) and the components of the university–school partnerships, counselor educators and school stakeholders can work together to support student mental health, school staff well-being and counselor-in-training competence.Originality/valueThe benefits and opportunities within the university–school partnerships are well documented. However, few researchers have described a model to support partnerships between the university counseling programs and urban elementary schools. We provide a best practice model using the principles of university–school partnerships and a school’s existing MTSS framework.
Beyond anthropocentrism in agricultural and resource economics
Authors: Espinosa Romain , Treich Nicolas 
Published: March 2024

AbstractWe argue that it is both possible and timely to relax the assumption of anthropocentrism in agricultural and resource economics. We advocate for the incorporation of sentientist principles by including the welfare of sentient animals within the social welfare function. To exemplify this non‐anthropocentric stance, we build on our recent works that incorporate the intrinsic value of farmed animals into food production and consumption. By recognising the externalities affecting animals, we justify the implementation of specific policies, such as a meat tax, which redistributes welfare from consumers and producers to farmed animals. Furthermore, we delve into the quantitative assessment of animal welfare and demonstrate its application to food policy, revealing the substantial economic and welfare impacts at stake. Expanding on our earlier model, we also emphasize the importance of introducing a ‘sentience premium’ within species conservation policies. This additional consideration ensures that the conservation efforts appropriately account for the intrinsic value of sentient beings living in the wild.
A New Mode of Protection: The Case for Redesigning our Policing and Public Safety Institutions
Authors: Muir Rick 
Published: March 2024

AbstractThe society in which the police operate is changing radically, meaning that we need to rethink our policing and wider public safety institutions. Policing needs to be clearer as to its purpose, and needs to work in a much more collaborative way with other public services, particularly to do more to prevent crime and harm. Policing needs new or reformed capabilities in areas such as legitimacy, technology and skills. And finally, policing needs a better organisational platform if it is to play its role in keeping people safe in the transformed conditions of the twenty‐first century.
Stem cell secretome treatment improves whole‐body metabolism, reduces adiposity, and promotes skeletal muscle function in aged mice
Authors: Fennel Zachary J. , Bourrant Paul‐Emile , Kurian Anu Susan , Petrocelli Jonathan J. , de Hart Naomi M. M. P. , Yee Elena M. , Boudina Sihem , Keirstead Hans S. , Nistor Gabrielle , Greilach Scott A. , Berchtold Nicole C. , Lane Thomas E. , Drummond Micah J. 
Published: March 2024

AbstractAging coincides with the progressive loss of muscle mass and strength, increased adiposity, and diminished physical function. Accordingly, interventions aimed at improving muscle, metabolic, and/or physical health are of interest to mitigate the adverse effects of aging. In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth, cytoskeletal remodeling, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22–24 months) compared to saline‐injected aged‐matched controls. Secretome delivery substantially increased whole‐body lean mass and decreased fat mass, corresponding to higher myofiber cross‐sectional area and smaller adipocyte size, respectively. Secretome‐treated mice also had greater whole‐body physical function (grip strength and rotarod performance) and had higher energy expenditure and physical activity levels compared to control mice. Furthermore, secretome‐treated mice had greater skeletal muscle Pax7+ cell abundance, capillary density, collagen IV turnover, reduced intramuscular lipids, and greater Akt and hormone sensitive lipase phosphorylation in adipose tissue. Finally, secretome treatment in vitro directly enhanced muscle cell growth and IL‐6 production, and in adipocytes, it reduced lipid content and improved insulin sensitivity. Moreover, indirect treatment with secretome‐treated myotube culture media also enhanced muscle cell growth and adipocyte size reduction. Together, these data suggest that intramuscular treatment with a stem cell secretome improves whole‐body metabolism, physical function, and remodels skeletal muscle and adipose tissue in aged mice.
Sex differences in heart rate variability measures that predict alcohol drinking in rats
Authors: Frasier Raizel M. , Starski Phillip A. , de Oliveira Sergio Thatiane , Grippo Angela J. , Hopf F. Woodward 
Published: March 2024

AbstractProblem alcohol drinking continues to be a substantial cost and burden. In addition, alcohol consumption in women has increased in recent decades, and women can have greater alcohol problems and comorbidities. Thus, there is a significant need for novel therapeutics to enhance sex‐specific, individualized treatment. Heart rate (HR) and HR variability (HRV) are of broad interest because they may be both biomarkers for and drivers of pathological states. HRV reflects the dynamic balance between sympathetic (SNS, ‘fight or flight’) and parasympathetic (PNS, ‘rest and digest’) systems. Evidence from human studies suggest PNS predominance in women and SNS in men during autonomic regulation, indicating the possibility of sex differences in risk factors and physiological drivers of problem drinking. To better understand the association between HRV sex differences and alcohol drinking, we examined whether alcohol consumption levels correlated with time domain HRV measures (SDNN and rMSSD) at baseline, at alcohol drinking onset, and across 10 min of drinking, in adult female and male Wistar rats. In particular, we compared both HRV and HR measures under alcohol‐only and compulsion‐like conditions (alcohol + 10 mg/L quinine), because compulsion can often be a significant barrier to treatment of alcohol misuse. Importantly, previous work supports the possibility that different HRV measures could be interpreted to reflect PNS versus SNS influences. Here, we show that females with higher putative PNS indicators at baseline and at drinking onset had greater alcohol consumption. In contrast, male intake levels related to increased potential SNS measures at drinking onset. Once alcohol was consumed, HR predicted intake level in females, perhaps a pharmacological effect of alcohol. However, HRV changes were greater during compulsion‐like intake versus alcohol‐only, suggesting HRV changes (reduced SNS in females, reduced PNS and increased HR in males) specifically related to aversion‐resistant intake. We find novel and likely clinically relevant autonomic differences associated with biological sex and alcohol drinking, suggesting that different autonomic mechanisms may promote differing aspects of female and male alcohol consumption.