bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adhesion and sealing of different universal adhesive systems associated with bulk‐fill resins after using endodontic irrigation solutions: An in vitro study
Authors: Omoto Érika Mayumi , Catelan Anderson , Santos Paulo Henrique dos , Cintra Luciano Tavares Angelo , Ramos Fernanda de Souza e Silva , Pavani Caio César , Briso André Luiz Fraga , Fagundes Ticiane Cestari 
Published: March 2024

AbstractThis study aimed to evaluate the interface of universal adhesive (UA) with bulk‐fill resin (BF) and dentin, after endodontic irrigation. The pulp chamber of 96 molars was irrigated with chlorhexidine 2% (CHX) or sodium hypochlorite 5.25% (NaOCl) and restored according to three restorative protocols. Microtensile bond strength (μTBS) and nanoleakage tests were performed after 24 h of thermocycling. Kruskal Wallis, Mann–Whitney and Wilcoxon were performed (p < 0.05). Comparing restorative systems, a difference was found only when irrigated with CHX after 24 h. CHX provided higher μTBS than NaOCl after 24 h for two restorative protocols; after thermocycling, NaOCl provided the greatest μTBS than CHX for one group. Decreased μTBS was observed for all restorative systems when CHX was used after thermocycling. NaOCl demonstrated the highest nanoleakage. The composition of UA influenced the immediate adhesion and sealing to BF when CHX was used; ageing has a deteriorating effect on adhesion and sealing for all restorative systems.
Accelerometer‐based sedentary time, light physical activity, and moderate‐to‐vigorous physical activity from childhood with arterial stiffness and carotid IMT progression: A 13‐year longitudinal study of 1339 children
Authors: Agbaje Andrew O. , Barker Alan R. , Lewandowski Adam J. , Leeson Paul , Tuomainen Tomi‐Pekka 
Published: March 2024

AbstractAimsWe examined the longitudinal associations of sedentary time (ST), light physical activity (LPA), and moderate‐to‐vigorous PA (MVPA) from childhood with carotid‐femoral pulse wave velocity (cfPWV), a measure of arterial stiffness and carotid intima‐media thickness (cIMT).MethodsWe studied 1339 children, aged 11 years from Avon Longitudinal Study of Parents and Children, UK, followed up for 13 years. Accelerometer‐based ST, LPA, and MVPA were assessed at ages 11, 15, and 24 years clinic visits. cfPWV and cIMT were measured with Vicorder and ultrasound, respectively, at ages 17 and 24 years.ResultsAmong 1339 [56.4% female] participants, mean ST increased from ages 11 through 24 years, while mean LPA and MVPA decreased. Persistently high ST tertile from childhood was associated with increased cfPWV progression, effect estimate 0.047 m/s; [(95% CI 0.005 to 0.090); p = 0.030], but not cIMT progression. Persistently high LPA tertile category was associated with decreased cfPWV progression in males −0.022 m/s; [(−0.028 to −0.017); p < 0.001] and females −0.027 m/s; [(−0.044 to −0.010); p < 0.001]. Cumulative LPA exposure decreased the odds of progressively worsening cfPWV [Odds ratio 0.994 (0.994–0.995); p < 0.0001] and cIMT. Persistent exposure to ≥60 min/day of MVPA was paradoxically associated with increased cfPWV progression in males 0.053 m/s; [(0.030 to 0.077); p < 0.001] and females 0.012 m/s; [(0.002 to 0.022); p = 0.016]. Persistent exposure to ≥60 min/day of MVPA was inversely associated with cIMT progression in females −0.017 mm; [(−0.026 to −0.009); p < 0.001].ConclusionLPA >3 h/day from childhood may attenuate progressively worsening vascular damage associated with increased ST in youth.
Interdisciplinary methodology for the characterisation of archaeological metal grave goods from the Museum of Patagonia by PIXE, DRX, and SEM/EDS
Authors: Schweickardt Josefina M. , Pérez Pablo D. , Morán Mauricio , Villelli Marcia Bianchi , Cantargi Florencia 
Published: March 2024

AbstractWe present a study of a selection of metal ornaments belonging to archaeological funerary goods from Patagonic Indigenous groups. They are part of the ‘Andrés Giai’ Collection, under the guard of the Museum of Patagonia (Nahuel Huapi National Park [PNNH]; National Parks Administration [APN]), Argentina. The absence of contextual information and its current conservation status motivated the design of an interdisciplinary methodology to develop an Integral Conservation Plan that considered the selection of analytical techniques. Here, we implemented complementary nondestructive characterisation techniques such as particle induced X‐ray emission (PIXE), X‐ray diffraction (XRD) and scanning electron microscopy coupled with energy dispersive X‐ray spectroscopy (SEM/EDS). We developed a methodology enabling us to characterise each piece with respect to its metallic composition and degradation products, and in certain cases, their manufacturing process. These findings have contributed with essential information for the tailored conservation treatment proposal. Moreover, they provided key information in regard to the reconstruction of contextual data for each piece. In addition, the methodology proposed for the Integral Conservation Plan takes into account an optimisation of the techniques to be used in order to minimise unnecessary handling of goods whilst ensuring an appropriate use of technological and economic resources whilst minimising time on potentially unconclusive measurements and results.
Proteomics landscape and machine learning prediction of long‐term response to splenectomy in primary immune thrombocytopenia
Authors: Sun Ting , Chen Jia , Xu Yuan , Li Yang , Liu Xiaofan , Li Huiyuan , Fu Rongfeng , Liu Wei , Xue Feng , Ju Mankai , Dong Huan , Wang Wentian , Chi Ying , Yang Renchi , Chen Yunfei , Zhang Lei 
Published: March 2024

SummaryThis study aimed to identify key proteomic analytes correlated with response to splenectomy in primary immune thrombocytopenia (ITP). Thirty‐four patients were retrospectively collected in the training cohort and 26 were prospectively enrolled as validation cohort. Bone marrow biopsy samples of all participants were collected prior to the splenectomy. A total of 12 modules of proteins were identified by weighted gene co‐expression network analysis (WGCNA) method in the developed cohort. The tan module positively correlated with megakaryocyte counts before splenectomy (r = 0.38, p = 0.027), and time to peak platelet level after splenectomy (r = 0.47, p = 0.005). The blue module significantly correlated with response to splenectomy (r = 0.37, p = 0.0031). KEGG pathways analysis found that the PI3K‐Akt signalling pathway was predominantly enriched in the tan module, while ribosomal and spliceosome pathways were enriched in the blue module. Machine learning algorithm identified the optimal combination of biomarkers from the blue module in the training cohort, and importantly, cofilin‐1 (CFL1) was independently confirmed in the validation cohort. The C‐index of CFL1 was >0.7 in both cohorts. Our results highlight the use of bone marrow proteomics analysis for deriving key analytes that predict the response to splenectomy, warranting further exploration of plasma proteomics in this patient population.
Comparison of Systems and Outcomes for Safeguarding Children in Australia and Norway: A Decade of Rapid Change
Authors: Kojan Bente Heggem , Russ Erica , Skrove Gaute , Lonne Bob 
Published: March 2024

ABSTRACTUsing aggregated national data, this paper re‐examines the outcomes of the Australian and Norwegian protective systems during the past decade and compares it to the trends and issues identified in our earlier 2012 study. We outline the context of increased service demand affecting both countries with rapid expansion and reform of their policies and approaches. A convergence has been occurring regarding their focus upon risk and its relationship with family support. However, in Australia, there was an increasing attempt to provide greater support and reduce its rate of investigation of notifications, but there was increasing rates of children in state care, particularly for Indigenous children. In Norway, there is less appetite for risk and consequently far higher rates of investigation, but their propensity for providing a diverse array of family support has been decreasing yet remains far greater than in Australia. Nonetheless, Norway's rate of children in state care is increasing, but not for children under 5 years, whereas Australia is removing far more infant children and having them in care longer, while Norway has far more adolescents in care, particularly in residential care. Within stretched systems, both countries are needing to develop workforce planning and development strategies.
Love on the developing brain: Maternal sensitivity and infants’ neural responses to emotion in the dorsolateral prefrontal cortex
Authors: Stern Jessica A. , Kelsey Caroline M. , Yancey Heath , Grossmann Tobias 
Published: March 2024

AbstractInfancy is a sensitive period of development, during which experiences of parental care are particularly important for shaping the developing brain. In a longitudinal study of N = 95 mothers and infants, we examined links between caregiving behavior (maternal sensitivity observed during a mother–infant free‐play) and infants’ neural response to emotion (happy, angry, and fearful faces) at 5 and 7 months of age. Neural activity was assessed using functional Near‐Infrared Spectroscopy (fNIRS) in the dorsolateral prefrontal cortex (dlPFC), a region involved in cognitive control and emotion regulation. Maternal sensitivity was positively correlated with infants’ neural responses to happy faces in the bilateral dlPFC and was associated with relative increases in such responses from 5 to 7 months. Multilevel analyses revealed caregiving‐related individual differences in infants’ neural responses to happy compared to fearful faces in the bilateral dlPFC, as well as other brain regions. We suggest that variability in dlPFC responses to emotion in the developing brain may be one correlate of early experiences of caregiving, with implications for social‐emotional functioning and self‐regulation.Research Highlights
Infancy is a sensitive period of brain development, during which experiences with caregivers are especially important.
This study examined links between sensitive maternal care and infants’ neural responses to emotion at 5–7 months of age, using functional near‐infrared spectroscopy (fNIRS).
Experiences of sensitive care were associated with infants’ neural responses to emotion—particularly happy faces—in the dorsolateral prefrontal cortex.
Analyzing horizontal integration and market efficiency in platform enterprises: A case study of exchanges
Authors: Liu Min , Anwar Sajid 
Published: March 2024

AbstractAs a platform for the trading of bulk commodities, securities, and futures, exchanges, characterized by platform‐like attributes, provide inexhaustible power for the further development of commodity economy through horizontal integration. This paper examines the international integration landscape of the modern exchanges through the lens of platform economy theory, specifically examining the ramifications of their horizontal integration on market efficiency. Employing the net utility hypothesis within the Hotelling model, we construct a nuanced trader utility model. Through a comparative analysis of platform profit, trader utility, and social welfare, the research discerns the impact of exchanges' horizontal integration. We highlight the intrinsic incentives for such integration within exchanges and put forth pertinent policy recommendations, adding a dimension of practical relevance to the academic discourse. The paper concludes by highlighting the role of government in promoting the efficiency of platform enterprises.
Horizon scanning: Tools to identify emerging threats to plant health in a changing world
Authors: Antoniou A. , Abergel M. , Akrivou A. , Beale T. , Day R. , Fielder H. , Larenaudie M. , MacLeod A. , Rosace M. C. , Sarakatsani E. , Stinziano J. R. , Szyniszewska A. M. , Suffert M. , Tramontini S. 
Published: March 2024

AbstractIn the context of risk analysis, horizon scanning activity is a necessary component of any foresight process. This applies also to the specific context of biological invasions, supported and accelerated by climate change and global trade. Today, various institutions and research centres are equipped with a set of tools and methods for early warning on emerging threats. In the case of plant pests, web signals, trade data, community science data and sentinel plants are important sources of information, then analysed and elaborated through multicriteria approaches. The scope of this paper is to provide an overview of current practices, highlighting strengths and shortcomings, and to inform future research and policy initiatives about opportunities to address global change in this field.
Genetic parentage reveals the (un)natural history of Central Valley hatchery steelhead
Authors: Goetz Laura C. , Nuetzel Hayley , Vendrami David L. J. , Beulke Anne K. , Anderson Eric C. , Garza John Carlos , Pearse Devon E. 
Published: March 2024

AbstractPopulations composed of individuals descended from multiple distinct genetic lineages often feature significant differences in phenotypic frequencies. We considered hatchery production of steelhead, the migratory anadromous form of the salmonid species Oncorhynchus mykiss, and investigated how differences among genetic lineages and environmental variation impacted life history traits. We genotyped 23,670 steelhead returning to the four California Central Valley hatcheries over 9 years from 2011 to 2019, confidently assigning parentage to 13,576 individuals to determine age and date of spawning and rates of iteroparity and repeat spawning within each year. We found steelhead from different genetic lineages showed significant differences in adult life history traits despite inhabiting similar environments. Differences between coastal and Central Valley steelhead lineages contributed to significant differences in age at return, timing of spawning, and rates of iteroparity among programs. In addition, adaptive genomic variation associated with life history development in this species varied among hatchery programs and was associated with the age of steelhead spawners only in the coastal lineage population. Environmental variation likely contributed to variations in phenotypic patterns observed over time, as our study period spanned both a marine heatwave and a serious drought in California. Our results highlight evidence of a strong genetic component underlying known phenotypic differences in life history traits between two steelhead lineages.
Diagnosis, management and long‐term outcome of four cases of carpal flexor retinaculum desmopathy
Authors: Giesecke Anne , Unkrüer Bernadette 
Published: March 2024

SummaryFour cases of flexor retinaculum desmopathy following an accident during the landing phase of jumping and their outcomes are discussed, and an overview of the subjects is provided. The four horses presented with a sudden onset of severe lameness during landing after jumping, which markedly decreased in the first few days. In all cases, the painful area was not localisable on the first day; however, marked swelling was observed on the second day and in all cases, the injury to the carpal flexor retinaculum was visible on ultrasound. The horses were sound in a straight line at 9 (Case 1), 4 (Case 2) and 2 (Case 3) weeks after the injury. Case 4 was not presented until 8 weeks after the incident. During subsequent examination, Case 4 was found to be sound, although it had not returned to training. The owner reported the lameness ended 4 weeks after the incident. All the horses successfully returned to their former competition levels and did not show any problems related to the carpal flexor retinaculum. However, there were significant differences in the regeneration times among the cases, ranging from 5 to 21 months.
Exploring the imprint of the institutional context on the urban network in China: Comparative analyses between corporate‐based networks with different ownership structures
Authors: Zhang Ze , Tang Zilai 
Published: March 2024

AbstractWhile the link between the urban network and institutional context has been well established, there has been less work on the effect of shifting political economy on the mechanism of its intercity flows. In this paper, the investment dataset of Chinese publicly listed firms is used to construct corporate‐based urban networks with different ownership structures. Two straightforward but effective comparative analyses are conducted. The first distinguishes between networks formed by state‐controlled and nonstate‐controlled firms, and the second distinguishes between subnetworks formed by central‐ and local‐state power. By surveying the distinctions from the perspectives of state–market relations and central‐local government relations, we argue that the urban network in China is shaped by the varied forms in which the central government, local governments, and the private sector interact. To gain a more proper knowledge of the geographical patterns, this research recommends further field research into enterprise‐based linkages of multiple ownership.
Role of PAR1 −506 deletion/insertion polymorphism in primary sclerosing cholangitis
Authors: Langhans Bettina , Kalthoff Sandra , Zhou Taotao , Weismüller Tobias J. , Lenzen Henrike , Nischalke Hans Dieter , Strassburg Christian P. , Lutz Philipp , Dold Leona 
Published: March 2024

AbstractAimPrimary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by inflammation of the intra‐ and extrahepatic bile ducts. Pathogenesis of PSC is still enigmatic but is likely to be multifactorial. Recently, we identified an interleukin‐6 (IL‐6)‐dependent signal transducer and activator of transcription 3 (STAT3) activation in CD4+ TH1 and TH17 cells in PSC. The IL‐6/STAT3 pathway was shown to be regulated by protease‐activated receptor 1 (PAR1) contributing to inflammation. The role of the PAR1 −506 deletion/insertion (Del/Ins) polymorphism in PSC has not yet been investigated.MethodsTwo hundred eighty four PSC patients (200 patients with inflammatory bowel diseases [IBD] and 84 without IBD) and 309 healthy controls were genotyped for PAR1 rs11267092 (−506 Del/Ins −13 bp). Results were correlated with clinical characteristics and transplant‐free survival.ResultsThe frequency of PAR1 –506 Ins allele carriers (Del/Ins and Ins/Ins) was significantly higher in PSC patients (57.0%) compared to healthy controls (39.8%). Furthermore, carriers of PAR1 −506 Ins allele were more likely to have PSC than noncarriers (odds ratio 2.01; 95% confidence interval, 1.45–2.79). Patients with PSC carrying the PAR1 −506 Ins allele showed significantly higher alanine aminotransferase serum levels (p = 0.0357) and a trend toward shorter transplant‐free survival time compared to noncarriers (8.9 ± 6.6 years vs. 10.5 ± 7.1 years; p = 0.076).ConclusionsOur study shows that PAR1 −506 Ins is significantly more frequent in people with PSC. As PAR1 −506 Ins allele carriers tended to have a shorter transplant‐free survival, PAR1 might play a role in the development and course of PSC.
Relationship between nurses' resilience and quality of professional life
Authors: Gündüz Emine Selda , Yildirim Nezaket , Akatin Yeliz , Gündoğdu Nurcan Akgül 
Published: March 2024

AbstractAimThis study aimed to investigate the correlation between the resilience levels of nurses and qualit of their professional life.BackgroundNurses' resilience level can affect their professional qualityof life. A higher resilience level enables them to manage stress and overcome challanges more effectively leading to enhanced patient care and satisfaction. Coversly, lower resiliance can lead to burnout, negatievly impacting both the nurses' wellbeing and the quality of service delivered to patients.IntroductionIt is crucial to understand the correlation between the professional life quality and resilience of nurses working in difficult conditions.MethodsThis correlational study was conducted between September 2021 and February 2022. A total of 276 nurses were included in the study. Data were collected using the Demographic Data Form consisting of sociodemographic characteristics, the Professional Quality‐of‐Life Scale, and the Resilience Scale for Adults.ResultsThe resilience score was above average, and the professional quality of life was high. Compassion satisfaction and compassion fatigue, which are components of professional quality of life, were moderate, and the burnout level was low. A robust positive correlation was observed between resilience and the professional quality of life. The linear regression model showed that choosing the profession unwillingly, dissatisfaction with the unit in which one works, and the level of psychological resilience are independent factors of professional quality of life.ConclusionAccording to the findings, high psychological resilience increases the quality of professional life. Resilience, choosing nursing willingly, and liking the unit in which one works are determinants of professional quality of life.Implications for nursing policyEnhancing the professional quality of life of nurses has important individual, institutional, and social consequences. Enhancing resilience has the potential to elevate the quality of professional life. Hence, it is important to develop national and international policies and models. Additionally, managers bear significant responsibilities in ensuring a positive work environment. Undoubtedly, having nurses work in units they like, feel happy in, and prefer will increase their professional quality of life and make positive contributions to patient care, the institution, and society.
Recent Advances, Approaches and Challenges in the Development of Universal Influenza Vaccines
Authors: Lim Caryn Myn Li , Komarasamy Thamil Vaani , Adnan Nur Amelia Azreen Binti , Radhakrishnan Ammu Kutty , Balasubramaniam Vinod R. M. T. 
Published: March 2024

ABSTRACTEvery year, influenza virus infections cause significant morbidity and mortality worldwide. They pose a substantial burden of disease, in terms of not only health but also the economy. Owing to the ability of influenza viruses to continuously evolve, annual seasonal influenza vaccines are necessary as a prophylaxis. However, current influenza vaccines against seasonal strains have limited effectiveness and require yearly reformulation due to the virus undergoing antigenic drift or shift. Vaccine mismatches are common, conferring suboptimal protection against seasonal outbreaks, and the threat of the next pandemic continues to loom. Therefore, there is a great need to develop a universal influenza vaccine (UIV) capable of providing broad and durable protection against all influenza virus strains. In the quest to develop a UIV that would obviate the need for annual vaccination and formulation, a multitude of strategies is currently underway. Promising approaches include targeting the highly conserved epitopes of haemagglutinin (HA), neuraminidase (NA), M2 extracellular domain (M2e) and internal proteins of the influenza virus. The identification and characterization of broadly neutralizing antibodies (bnAbs) targeting conserved regions of the viral HA protein, in particular, have provided important insight into novel vaccine designs and platforms. This review discusses universal vaccine approaches presently under development, with an emphasis on those targeting the highly conserved stalk of the HA protein, recent technological advancements used and the future prospects of a UIV in terms of its advantages, developmental obstacles and potential shortcomings.