bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining profiles of convergence and divergence in reports of parental warmth: Links to adolescent developmental problems
Authors: Sloan Carlie J. , Forrester Emily , Lanza Stephanie , Feinberg Mark E. , Fosco Gregory M. 
Published: April 2024

Abstract
Parental warmth during the transition from childhood to adolescence is a key protective factor against a host of adolescent problems, including substance use, maladjustment, and diminished well-being. Moreover, adolescents and parents often disagree in their perceptions of parenting quality, and these discrepancies may confer risk for problem outcomes. The current study applies latent profile analysis to a sample of 687 mother–father–6th grade adolescent triads to identify patterns of adolescent–parent convergence and divergence in perceptions of parental warmth. Five profiles were identified, and associations with adolescent positive well-being, substance use, and maladjustment outcomes in 9th grade were assessed. Patterns of divergence in which adolescents had a pronounced negative perception of parental warmth compared to parents, as well as those wherein pronounced divergence was present in only one adolescent–parent dyad, were associated with diminished positive well-being compared to adolescents who had more positive perceptions of warmth than parents. Having more negative perceptions of warmth compared to parents was also associated with elevated risk for alcohol and marijuana initiation, but only when the divergence was pronounced rather than more moderate. These findings add nuance to findings from previous between-family investigations of informant discrepancies, calling for further family-centered methods for investigating multiple perspectives.
Keratin-based topical cream for radiation dermatitis during head and neck radiotherapy: a randomised, open-label pilot study
Authors: Hughes Ryan T , Levine Beverly J , Frizzell Bart A , Greven Kathryn M , Porosnicu Mercedes , Lycan Thomas W , Burnett Luke R , Winkfield Karen M 
Published: April 2024

Abstract

Introduction:
Radiation dermatitis (RD) is a frequent toxicity during radiotherapy (RT) for head and neck cancer (HNC). We report the first use of KeraStat® Cream (KC), a topical, keratin-based wound dressing, in patients with HNC receiving RT.

Methods:
This pilot study randomized HNC patients treated with definitive or postoperative RT (≥60 Gy) to KC or standard of care (SOC), applied at least twice daily during and for 1-month after RT. Outcomes of interest included adherence to the assigned regimen (at least 10 applications per week of treatment), clinician- and patient-reported RD, and skin-related quality of life.

Results:
24 patients were randomized and completed the study. Most patients had stage III-IV disease and oropharynx cancer. Median RT dose was 68 Gy; the bilateral neck was treated in 19 patients, and 18 patients received concurrent chemotherapy. Complete adherence was observed in 7/12 (SOC) vs. 10/12 (KC, p = 0.65). Adherence by patient-week was 61/68 versus 64/67, respectively (p = 0.20). No differences in RD were observed between groups.

Conclusion:
A randomized trial of KC versus SOC in HNC patients treated with RT is feasible with good adherence to study agent. An adequately powered randomized study is warranted to test the efficacy of KC in reducing RD.
The Illusion of Harmony: Power, Politics, and Distributive Implications of Rights of Nature
Authors: Petel Matthias 
Published: April 2024

AbstractThis article argues that the Rights of Nature (RoN) framework is compatible with various ideological outlooks and political options. As a result, those initiatives may translate into extremely diverse institutional implementations with contrasted outcomes in terms of power distribution. The institutional design of RoN has deep political implications for various social groups who hold conflicting claims over certain territories. Hence, rather than transforming human-nature relations, RoN primarily transform the power relations between human communities. I delve into three conceptual frameworks that could shape the recognition of RoN and explore their respective distributive implications: green colonialism, environmental justice, and the focus on Indigeneity. Through this critical engagement, I wish to warn against the illusion of a post-political ecology where an ecocentric legal declaration would deliver human-nature harmony without deep political battles, social tensions, and economic confrontations. RoN as an abstract notion does not offer a ready-made toolkit to dismantle the legal architecture of fossil capitalism; nor does it provide clear guidance on the distribution of costs and benefits of the green transition.
Heterogeneity of Alexithymia Subgroups
Authors: Hou Chunna , Shi Haoling , Ma Yisheng , Chou Jun 
Published: April 2024

Abstract: Alexithymia is a subclinical experience in which individuals struggle to identify, distinguish, and describe their own emotions. It is most commonly measured with the self-reported Toronto Alexithymia Scale-20 (TAS-20). However, scholars hold different views on its structure, resulting in challenges in classifying individuals with alexithymia, which is detrimental to clinical diagnosis, counseling, and intervention. The present study aimed to investigate the types (or subgroups) of alexithymia within a sample of college students ( n = 707) from four Chinese universities. Two latent classes of three-factor two-class model solution were effectively identified by the Factor Mixture Model (FMM) approach: a “High-EOT alexithymia” class (18.2%) and a “Non-alexithymia” class (81.8%). The two subgroups exhibited similar performance in difficulty in identifying feelings (DIF) and difficulty in describing feelings (DDF), but they differed significantly in externally oriented thinking (EOT). This suggests that EOT might be a diagnostic criterion for alexithymia.
Advancing Eddy Parameterizations: Dynamic Energy Backscatter and the Role of Subgrid Energy Advection and Stochastic Forcing
Authors: Bagaeva Ekaterina , Danilov Sergey , Oliver Marcel , Juricke Stephan 
Published: April 2024

AbstractViscosity in the momentum equation is needed for numerical stability, as well as to arrest the direct cascade of enstrophy at grid scales. However, a viscous momentum closure tends to over‐dissipate eddy kinetic energy. To return excessively dissipated energy to the system, the viscous closure is equipped with what is called dynamic kinetic energy backscatter. The amplitude of backscatter is based on the amount of unresolved kinetic energy (UKE). This energy is tracked through space and time via a prognostic equation. Our study proposes to add advection of UKE by the resolved flow to that equation to explicitly consider the effects of nonlocality on the subgrid energy budget. UKE can consequently be advected by the resolved flow before it is reinjected via backscatter. Furthermore, we suggest incorporating a stochastic element into the UKE equation to account for missing small‐scale variability, which is not present in the purely deterministic approach. The implementations are tested on two intermediate complexity setups of the global ocean model FESOM2: an idealized channel setup and a double‐gyre setup. The impacts of these additional terms are analyzed, highlighting increased eddy activity and improved flow characteristics when advection and carefully tuned, stochastic sources are incorporated into the UKE budget. Additionally, we provide diagnostics to gain further insights into the effects of scale separation between the viscous dissipation operator and the backscatter operator responsible for the energy injection.
Nano-flow cytometry unveils mitochondrial permeability transition process and multi-pathway cell death induction for cancer therapy
Authors: Su Liyun , Xu Jingyi , Lu Cheng , Gao Kaimin , Hu Yunyun , Xue Chengfeng , Yan Xiaomei 
Published: April 2024

AbstractMitochondrial permeability transition (mPT)-mediated mitochondrial dysfunction plays a pivotal role in various human diseases. However, the intricate details of its mechanisms and the sequence of events remain elusive, primarily due to the interference caused by Bax/Bak-induced mitochondrial outer membrane permeabilization (MOMP). To address these, we have developed a methodology that utilizes nano-flow cytometry (nFCM) to quantitatively analyze the opening of mitochondrial permeability transition pore (mPTP), dissipation of mitochondrial membrane potential ($$\Delta$$
Δ
Ψm), release of cytochrome c (Cyt c), and other molecular alternations of isolated mitochondria in response to mPT induction at the single-mitochondrion level. It was identified that betulinic acid (BetA) and antimycin A can directly induce mitochondrial dysfunction through mPT-mediated mechanisms, while cisplatin and staurosporine cannot. In addition, the nFCM analysis also revealed that BetA primarily induces mPTP opening through a reduction in Bcl-2 and Bcl-xL protein levels, along with an elevation in ROS content. Employing dose and time-dependent strategies of BetA, for the first time, we experimentally verified the sequential occurrence of mPTP opening and $$\Delta$$
Δ
Ψm depolarization prior to the release of Cyt c during mPT-mediated mitochondrial dysfunction. Notably, our study uncovers a simultaneous release of cell-death-associated factors, including Cyt c, AIF, PNPT1, and mtDNA during mPT, implying the initiation of multiple cell death pathways. Intriguingly, BetA induces caspase-independent cell death, even in the absence of Bax/Bak, thereby overcoming drug resistance. The presented findings offer new insights into mPT-mediated mitochondrial dysfunction using nFCM, emphasizing the potential for targeting such dysfunction in innovative cancer therapies and interventions.
A conceptual framework for automation disengagements
Authors: Nordhoff S. 
Published: April 2024

AbstractA better understanding of automation disengagements can lead to improved safety and efficiency of automated systems. This study investigates the factors contributing to automation disengagements initiated by human operators and the automation itself by analyzing semi-structured interviews with 103 users of Tesla’s Autopilot and FSD Beta. The factors leading to automation disengagements are represented by categories. In total, we identified five main categories, and thirty-five subcategories. The main categories include human operator states (5), human operator’s perception of the automation (17), human operator’s perception of other humans (3), the automation’s perception of the human operator (3), and the automation incapability in the environment (7). Human operators disengaged the automation when they anticipated failure, observed unnatural or unwanted automation behavior (e.g., erratic steering, running red lights), or believed the automation is not capable to operate safely in certain environments (e.g., inclement weather, non-standard roads). Negative experiences of human operators, such as frustration, unsafe feelings, and distrust represent some of the adverse human operate states leading to automation disengagements initiated by human operators. The automation, in turn, monitored human operators and disengaged itself if it detected insufficient vigilance or speed rule violations by human operators. Moreover, human operators can be influenced by the reactions of passengers and other road users, leading them to disengage the automation if they sensed discomfort, anger, or embarrassment due to the automation’s actions. The results of the analysis are synthesized into a conceptual framework for automation disengagements, borrowing ideas from the human factor's literature and control theory. This research offers insights into the factors contributing to automation disengagements, and highlights not only the concerns of human operators but also the social aspects of this phenomenon. The findings provide information on potential edge cases of automated vehicle technology, which may help to enhance the safety and efficiency of such systems.
Prevalence of pulmonary tuberculosis and HIV infections and risk factors associated to tuberculosis in detained persons in Antananarivo, Madagascar
Authors: Rakotomanana Fanjasoa , Dreyfus Anou , Randrianarisoa Mirella M. , Raberahona Mihaja , Chevallier Elodie , Andriamasy Harizaka E. , Bernardson Barivola A. , Ranaivomanana Paulo , Ralaitsilanihasy Francklin , Rasoamaharo Miangaly , Randrianirisoa Sandro A. N. , Razafindranaivo Turibio A. , Rakotobe Liva , Ratefiharimanana Andosoa , Randriamanana Daniella A. , Rakotondrazanany Harolalaina , Cauchoix Bertrand , Baril Laurence , Rakotosamimanana Niaina , Randremanana Rindra V. 
Published: April 2024

AbstractThe incidence rate of tuberculosis in prisons is estimated to be 8 times greater than that in the general population in Madagascar. Our objectives were to estimate the prevalence of pulmonary tuberculosis and HIV infection among prisoners and to identify risk factors associated with tuberculosis. We conducted a cross-sectional study at the central prison of Antananarivo from March to July 2021. Individual male and female inmates aged ≥ 13 years who had lived in the prison for at least three months prior to the study period were included as participants. Acid-fast bacilli detection by microscopy and/or culture, an intradermal tuberculin test, a chest X-ray, and a rapid diagnostic orientation test for HIV were performed. Among 748 participants, 4 (0.5%) were confirmed to have pulmonary tuberculosis. Overall, 14 (1.9%) patients had “confirmed” or “probable” tuberculosis [0.90–2.84, 95% CI]. The proportion of participants with latent tuberculosis infection was 69.6% (517/743) based on a positive tuberculin test without clinical symptoms or radiography images indicating tuberculosis. Out of 745 HIV screening tests, three showed reactive results (0.4%). Age (OR = 4.4, 95% CI [1.4–14.0]) and prior tuberculosis treatment (or episodes) were found to be associated with confirmed and probable tuberculosis.
Estimation of haemoglobin using non-invasive portable device with spectroscopic signal application
Authors: Amrutha A. M. , Sidenur Bhagyalaxmi , P.S Balu , S.V Savitha , M.R Nagendra Gowda , Rajagopal Harshavardhan 
Published: April 2024

AbstractAn estimated 52% of non-pregnant women of reproductive age in India are estimated to be affected by anaemia, which is categorised as a chronic condition. In 2019–2021, the National Family Health Survey–5 (NFHS–5) which was undertaken revealed the following statistics about the prevalence of anaemia in the state of Karnataka. To estimate haemoglobin levels using non-invasive portable device among nursing students. A cross sectional study was done among students of Nursing college in central Karnataka for a period of 3 months. Total of 140 students were included in the study. EzeCheck haemoglobin estimation was done twice and was recorded in the same Google form. The frequency and percentage of variation of results between Haematology Analyzer and EzeCheck devices was presented with a range of difference such as 0, less than 1, 1.0 to 1.9, 2.0 to 2.9, 3.0 to 3.9, and 4.0 and above. The total prevalence of anaemia among nursing students was 57.8% and most of the students had moderate degree of anaemia (28.6%). Two readings of haemoglobin were taken and difference of readings were calculated and majority of the students had difference of < 0.5 gm/dl (61.4%) and only 1.4% of the students had difference of > 2 gm/dl. The mean difference of haemoglobin of two readings was 0.5 ± 0.5 gm/dl. The technology employed in this study bridges the gap between patients and anaemia diagnosis by providing screening services. The device provides the diagnosis via a non-invasive, IoT-enabled service at a low cost.
Phytochemical screening and insecticidal activities of some medicinal plants against the maize weevil, Sitophilus zeamais (Motschulsky) (Coleoptera: Curculionidae)
Authors: Gindaba Adugna , Negeri Mulugeta , Abdisa Bulti , Nemo Reda , Kitila Chala 
Published: April 2024

AbstractThis study emphasizes the phytochemical study of some locally available botanicals against maize weevils. Nine plant parts were collected from six plant species. The test plant powder (200 g) was suspended sequentially in 600 ml of petroleum ether, chloroform, acetone, methanol, and distilled water for 72 h with frequent agitation. Different concentrations of the crude extracts were applied to maize seeds at rates of 10 ml, 15 ml and 20 ml per 100 g. All treatments with different extracts at different rates of application showed significant differences (p < 0.05) in the cumulative mean percentage mortality of the maize weevil. The seed extract of Maesa lanceolata and Croton macrostachyus and the leaf extract of Clausena anisata showed cumulative percent mortality ranged 95.32–98.02% in 28 days after treatment application. There was no significant difference (p > 0.05) among all treatments for the prevention of F1 progeny emergence. In all extracts, Clausena anisata showed 100% inhibition of F1 progeny emergence. All treatments significantly reduced seed weight loss and damage. The treated maize seeds were germinated with an acceptable germination quality. In conclusion, an increased dosage of the extract resulted in significant mortality in maize weevils. The seed extracts of Maesa lanceolata and Croton macrostachyus and Clausena anisata leaf extract were observed to be the most promising botanical in protecting stored maize against maize weevil.
Chemokine expression in sera of patients with microscopic polyangiitis and granulomatosis with polyangiitis
Authors: Lee Ji Eun , Yoon Taejun , Lee Sang-Won , Ahn Sung Soo 
Published: April 2024

AbstractWe evaluated chemokine expression and its correlation with disease activity in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) (MPA/GPA). Serum CCL2, CCL4, CCL19, CXCL1, CXCL2, and CX3CL1 level in 80 patients were analysed using multiple enzyme-linked immunosorbent assays. Correlations between variables were investigated using Pearson’s correlation analysis, and receiver operator curve analysis was performed to identify optimal CX3CL1 values in determining active disease. Multivariate logistic regression analysis was done to evaluate predictors of active disease. CCL4 (r = 0.251, p = 0.025), CXCL1 (r = 0.270, p = 0.015), and CX3CL1 (r = 0.295, p = 0.008) significantly correlated with BVAS, while CX3CL1 was associated with five-factor score (r =  − 0.290, p = 0.009). Correlations were revealed between CCL2 and CCL4 (r = 0.267, p = 0.017), CCL4 and CXCL1 (r = 0.368, p < 0.001), CCL4 and CXCL2 (r = 0.436, p < 0.001), and CXCL1 and CXCL2 (r = 0.518, p < 0.001). Multivariate analysis revealed serum CX3CL1 levels > 2408.92 pg/mL could predict active disease (odds ratio, 27.401, p < 0.001). Serum chemokine levels of CCL4, CXCL1, and CX3CL1 showed association with disease activity and especially, CX3CL1 > 2408.92 pg/mL showed potential in predicting active MPA/GPA.
Radical electron-induced cellulose-semiconductors
Authors: Fukuhara Mikio , Yokotsuka Tomonori , Samoto Tetsuo , Kumadaki Masahiko , Takeda Mitsuhiro , Hashida Toshiyuki 
Published: April 2024

AbstractBio-semiconductors are expected to be similar to organic semiconductors; however, they have not been utilized in application yet. In this study, we show the origin of electron appearance, N- and S-type negative resistances, rectification, and switching effects of semiconductors with energy storage capacities of up to 418.5 mJ/m2 using granulated amorphous kenaf cellulose particles (AKCPs). The radical electrons in AKCP at 295 K appear in cellulose via the glycosidic bond C1–O1·–C4. Hall effect measurements indicate an n–type semiconductor with a carrier concentration of 9.89 × 1015/cm3, which corresponds to a mobility of 10.66 cm2/Vs and an electric resistivity of 9.80 × 102 Ωcm at 298 K. The conduction mechanism in the kenaf tissue was modelled from AC impedance curves. The light and flexible cellulose-semiconductors may open up new avenues in soft electronics such as switching effect devices and bio-sensors, primarily because they are composed of renewable natural compounds.
Caught in the crossfire: biodiversity conservation paradox of sociopolitical conflict
Authors: Hilario-Husain Bona Abigail , Tanalgo Krizler Cejuela , Guerrero Sarrah Jane C. , Garcia Francisco Gil N. , Lerios Tessie E. , Garcia May Eva Z. , Alvaro-Ele Renee Jane , Manampan-Rubio Meriam , Murray Sedra A. , Casim Lothy F. , Delos Reyes Jamaica L. , Dela Cruz Kier Celestial , Abdullah Sumaira S. , Balase Shiela Mae Prince , Respicio Jeaneth Magelen V. , Lidasan Asraf K. , Buday Zafrullah S. , Cabasan Ma. Teodora N. , Pimentel Jonald L. , Tamon Florie Jane M. , Agduma Angelo Rellama 
Published: April 2024

AbstractThe current state of global biodiversity is confronted with escalating threats arising from human-induced environmental changes and a growing array of unpredictable challenges. However, effective conservation efforts are often hindered by limited knowledge, especially in developing economies such as the Philippines. The limitations imposed by these shortfalls in biodiversity knowledge hamper the capacity to protect biodiversity in light of the continuing extinction crisis. Our study revealed that areas with higher conflict levels exhibited lower species richness, fewer occurrence records, and reduced forest cover. This finding provides initial evidence for the relationship between sociopolitical conflict and biodiversity in the Philippines. We posit that the security risks caused by sociopolitical conflicts could have a negative impact on conservation efforts, particularly in terms of monitoring and implementing measures to protect natural resources. The links that bind armed conflict and biodiversity conservation are multifaceted and complex issues that warrant greater scientific and political attention. Finally, we identified 10 meaningful approaches to address shortfalls in biodiversity knowledge in conflicted areas, particularly incorporating conflict-sensitive approaches, considering the geopolitical context and conflict dynamics to adapt and align their strategies with local realities for more effective conservation efforts.
Kinetic inductance in superconducting CoSi2 coplanar microwave transmission lines
Authors: Mukhanova Ekaterina , Zeng Weijun , Heredia Elica Anne , Wu Chun-Wei , Lilja Ilari , Lin Juhn-Jong , Yeh Sheng-Shiuan , Hakonen Pertti 
Published: April 2024

We have looked into cobalt disilicide (CoSi2) as a potential building block for superconducting quantum circuits. In order to achieve this, we annealed a thin layer of Co to create microwave cavities with thickness of d = 10–105 nm from CoSi2 embedded in the silicon substrate. The cavity properties were measured as a function of temperature and power. In the films measuring 10 and 25 nm, we find a significant kinetic inductance LK with a non-BCS power-law variation δLK ∝ T4.3±0.2 at low temperatures. The quality factor of the studied microwave resonances varied from 3 × 103 (d = 10 nm) to ∼5 × 104 (d = 105 nm) and increased as d(A − log d) with thickness, with two-level systems having very little effect. The power dependence of kinetic inductance was analyzed in terms of heat flow due to electron–phonon coupling, which was found to be stronger than estimated for heat relaxation by regular quasiparticles.