bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vaginal melanoma and the role of regional chemotherapy
Authors: Beg Mansoor H. , Muchmore James H. , Carter R. Davilene , Krementz Edward T. 
Published: February 2007

AbstractVaginal melanoma is a rare cancer usually diagnosed as a locally advanced disease. Aggressive surgical management of the primary tumor and local‐regional recurrences, combined with the use of adjuvant radiation and chemotherapy, improves disease‐free interval and, perhaps, survival times. Techniques of regional chemotherapy allow the delivery of high doses of chemotherapy to the tumor bed, while minimizing systemic toxicities. These treatments can be used to decrease tumor size, render bulky tumors resectable, and decrease the need for radical procedures. Additionally, they may help eradicate clinically inapparent local‐regional disease and have a favorable effect on survival times. © 1993 Wiley‐Liss, Inc.
Giant cell fibroblastoma
Authors: Nair Reena , Kane Shubhada V. , Borges Anita , Advani Suresh H. 
Published: February 2007

AbstractA report of a 11/2‐year‐old male child diagnosed as a case of giant cell fibroblastoma is described and the available literature on this neoplasm is reviewed. The tumor consists of a mixture of spindle cells and multinucleated giant cells in a myxoid or collagenous background. The pathological findings and clinical course suggest that these tumors be classified with fibromatoses of childhood. Removal of the tumor with wide excision is sufficient and these patients do not require any form of chemotherapy. © 1993 Wiley‐Liss, Inc.
Benefits of a multidisciplinary approach to breast care
Authors: August David A. , Carpenter Lynne C. , Harness Jay K. , Delosh Tom , Cody Robert L. , Adler Dorit D. , Oberman Harold , Wilkins Edwin , Schottenfeld David , McNeely S. Gene , Lichter Allen S. 
Published: February 2007

AbstractThe University of Michigan Breast Care Center (BCC) was established in 1985 to provide comprehensive, multidisciplinary diagnosis and treatment of benign and malignant breast disease. This work presents an overview of our experience in the BCC and assesses the clinical, academic, financial, and educational effectiveness of the program. A database was used to generate a list of all patients seen in the BCC between February 1, 1985 and December 31, 1991. Participating departments provided information regarding outpatient, inpatient, clinical and consultative activities, and referral patterns attributable to BCC endeavors. BCC educational and academic activities were reviewed and profiled. Clinical information was culled from the BCC database, hospital records, and the hospital tumor registry. The BCC has resulted in a fivefold increase in breast care related activity at the University of Michigan Medical Center. Over half of the patients treated in the BCC with primary operable breast cancer receive breast‐conserving therapy. The BCC performs a unique educational function, providing the primary breast care experience for house staff as well as one third of the third year medical school class. The BCC supports over 20 clinical research protocols, and patient enrollment in clinical trials has increased dramatically since 1985. The BCC also provides support to basic science researchers receiving over 2.5 million dollars in peer reviewed direct cost support. These data suggest that a multidisciplinary approach to patient care as embodied by the BCC can be clinically, financially, and academically superior and productive. This model warrants further investigation not only in the field of breast care, but also in other clinical situations that require multidisciplinary input and therapy. © 1993 Wiley‐Liss, Inc.
Increased tumor localization by monoclonal antibody A7 after F(ab')2 fragmentation in athymic nude mice bearing human pancreatic carcinomas
Authors: Otsuji Eigo , Yamaguchi Toshiharu , Yamaoka Nobuki , Kotani Tatsuya , Tsurumi Hiroshi , Kitamura Kazuya , Yamaguchi Nozomi , Takahashi Toshio 
Published: February 2007

AbstractMuch recent research has been directed toward the use of monoclonal antibodies (MoAbs) for the immunodetection of solid tumors. In pancreatic cancer, conventional immunoscintigraphy using intact MoAbs remains disappointing. In this study, 125I‐labeled F(ab')2 fragments produced by pepsin digestion of MoAb A7 were injected intravenously into nude mice bearing human pancreatic cancer, HPC‐YS, xenografts that have previously been shown to react specifically with MoAb A7. The tumor tissue/blood ratio of 125I‐labeled F(ab')2 fragments of MoAb A7 increased with time and was much higher than those for normal tissues. Moreover, the tumor tissue/blood ratio of 125I‐labeled F(ab')2 fragments was greater than that of intact MoAb A7, although the F(ab')2 accumulation was less than that of intact MoAb A7 in the tumor. These results suggest that F(ab')2 fragments of MoAb A7 may be suitable carriers of radionuclides for immunodetection of human pancreatic cancer. © 1993 Wiley‐Liss, Inc.
Relation between the incorporation of 5‐fluorouracil into liver carcinoma and normal tissue RNA at hepatic arterial administration in the rat is altered by overnight starvation
Authors: Roos Gunnel , Stenram Unne 
Published: February 2007

AbstractThe cytotoxicity of 5‐FUra has been related to its incorporation into RNA. In a model of secondary liver cancer in the rat, the incorporation of 5‐FUra into the acid‐soluble fraction, RNA and DNA of several normal tissues and an adenocarcinoma of the colon transplanted to the liver was determined. A therapeutic labelled dose of the drug was infused via the hepatic artery for 2 hr and the rats killed 1 hr later. Half of the rats were starved overnight before treatment. The incorporation of 5‐FUra into liver and intestinal RNA increased at starvation. It was unchanged in kidney and bone marrow.The incorporation into tumor RNA decreased insignificantly. The incorporation into tumor RNA was significantly higher than in hepatic, intestinal, and renal RNA at ad libitum feeding. This difference disappeared at overnight starvation. © 1993 Wiley‐Liss, Inc.
Carcinoembryonic antigen (CEA) in stage IV gastric cancer as a risk factor for liver metastasis: A univariate and multivariate analysis
Authors: Ikeda Yoichi , Mori Masaki , Adachi Yosuke , Matsushima Tetsuya , Sugimachi Keizo , Saku Motonori 
Published: February 2007

AbstractSerum carcinoembryonic antigen (CEA) levels were determined in 68 patients with Stage IV gastric cancers, the objective being to examine the clinicopathological relationship between the metastatic patterns of gastric cancer and the serum CEA level. Of the 68 patients, 31 were diagnosed as cases of liver metastases and 37 as cases of peritoneal dissemination. Serum CEA levels were elevated in 21 of 31 patients (67.8%) with liver metastases and in 7 of 37 patients (18.9%) with peritoneal dissemination (P < 0.01). A univariate analysis showed that liver metastasis correlated with a young age (P < 0.01), the lower portion of stomach (P < 0.05), Borrmann types 1 and 2 (P < 0.01), differentiated type (P < 0.01), and nonserosal involvement (P < 0.05) more than did peritoneal dissemination. A multivariate analysis showed that in addition to Borrmann type 1 and 2, elevated CEA levels (>2.5 ng/ml) is an independent risk factor involved in liver metastasis. Thus careful follow‐up and postoperative adjuvant therapy are required for patients with elevated CEA levels, even with “curative” resection. © 1993 Wiley‐Liss, Inc.
Prognostic value of the number of metastatic lymph nodes in gastric cancer with radical surgery
Authors: Isozaki Hiroshi , Okajima Kunio , Kawashima Yasuo , Yamada Sinichi , Nakata Eiji , Nishimura Junko , Ichinona Tadashi 
Published: February 2007

AbstractTo evaluate the effectiveness of extended lymph node dissection in gastric cancer, the relationship between the number of lymph nodes with metastasis and the long‐term outcome was studied retrospectively in 761 patients who underwent curative resection with extensive lymph node dissection. The cumulative 5‐year survival rate was 85.8% in patients without lymph node metastasis, 60.2% in those with 1–4 lymph nodes, 35.6% with 5–10 nodes, and 12.3% with 11 or more nodes involved. Concerning N2 or N3 patients in whom metastatic lymph nodes would have remained without extensive dissection, the 5‐year survival rate was 70.5% in those with 1–4 lymph nodes involved and 44.0% with 5 or more lymph nodes involved when no serosal invasion was observed. It was 38.5% with 1–4 lymph nodes and 5% with 5 or more lymph nodes involved when serosal invasion was observed. These results suggest that extensive lymph node dissection is effective in gastric cancer patients without serosal invasion and, when only a few lymph nodes are involved, also in those with serosal invasion. However, it is not considered to be effective in patients with serosal invasion and metastasis to many lymph nodes. Combination therapies are thought to be required in such patients. © 1993 Wiley‐Liss, Inc.
Flow cytometric DNA analysis of interleukin‐2 responsive renal cell carcinoma
Authors: Gomella Leonard G. , Ehya Hormoz , Steinberg Seth M. , Rupp Michael , Merino Maria , Robertson Cary , Linehan W. Marston 
Published: February 2007

AbstractAdoptive immunotherapy using interleukin‐2 (IL‐2) based therapy can result in marked tumor regression in some patients with metastatic renal cell carcinoma. DNA flow cytometry has not been previously studied as a predictor of outcome of this therapy. Archival paraffin embedded tumors were studied in 23 IL‐2 treated patients with metastatic renal cell carcinoma. Eleven patients were complete responders (CR) and 12 were nonresponders (NR). In the CR group, 4/11 (40%) were diploid and 7/11 (60%) were aneuploid. In the NR group, 9/12 (75%) were diploid and 3/12 (25%) were aneuploid. Although there was a trend that patients with an aneuploid DNA pattern were more likely to undergo a complete response, ploidy pattern alone was not significantly predictive of response (p2 = 0.10, Fischer's exact test). When combining ploidy pattern with other variables that were predictive for complete response, such as good performance status and a higher pretreatment weight, prediction of complete response was not improved by including ploidy. This preliminary report suggests that DNA ploidy does not appear to provide any additional information concerning responsiveness to IL‐2 based immunotherapy beyond that obtained by performance status and pretreatment weight in this patient population. © 1993 Wiley‐Liss, Inc.
Changes in histopathological features of gastric carcinoma over a 26‐year period (1965–1990)
Authors: Inoue Manami , Tajima Kazuo , Kitoh Tsuyoshi , Sakamoto Junichi , Yamamura Yoshitaka , Sato Tsuneko , Suzuki Ryoji , Koshikawa Takashi , Nakamura Shigeo , Suchi Taizan 
Published: February 2007

AbstractEpidemiological study has shown that the incidence rate of gastric carcinoma in Japan has declined recently. To explore the factors that have influenced this decrease, the changing pattern in clinico‐pathological features of gastric carcinoma was studied from the epidemiological point of view. The 5,015 cases of gastric carcinoma treated with gastrectomy at Aichi Cancer Center Hospital from 1965–1990 were divided into two histopathological types: the well‐differentiated and other types. Proportional distribution was compared over the three different periods (1965–1973, 1974–1982, 1983–1990) according to the clinico‐pathological features of the gastric carcinoma, i.e., sex, age, lesional location, etc. The recent relative decline of gastric carcinoma is due mainly to the decline of carcinoma of the well‐differentiated type. This decline has been highly correlated to the decline in carcinoma of the antrum, which has been the most common in Japan. This changing pattern of clinicopathological features of Japanese gastric carcinoma might be affected by the change of exposure patterns to epidemiological factors, i.e., a Westernizing diet. © 1993 Wiley‐Liss, Inc.
Blood transfusion practices after resection of intrathoracic neoplasms
Authors: Gwin John L. , Keller Steven M. 
Published: February 2007

AbstractA heightened awareness of the risks of blood transfusion and the previously reported common administration of blood products (31–55%) following thoracic surgery prompted us to evaluate our recent transfusion practices. Of 355 patients who underwent a thoracotomy or median sternotomy from July 1987 through September 1991, 91 (25.6%) were transfused a mean 3.1 units of blood within the first 30 postoperative days. Transfused and nontransfused patients were compared with respect to age, body surface area, preoperative hemoglobin, estimated operative blood loss, and estimated postoperative hemoglobin. Univariate analyses of variance indicate significant (P < 0.01) differences between the two groups of patients for preoperative hemoglobin, blood loss, and estimated postoperative hemoglobin. Transfusion frequencies by year of operation are: 1987, 36%; 1988, 31%; 1989, 33%; 1990, 23%; 1991, 15%. We conclude that our transfusion requirements are lower than reported rates and that clinical parameters may help predict the need for subsequent transfusion.
Testicular circulatory isolation in man: Comparison of radionuclide angiography with doppler evaluation
Authors: Farr Susan A. , Littlefield James L. , Fletcher James W. , Camacho David W. , Johnson Frank E. 
Published: February 2007

AbstractTesticular circulatory isolation (TCI) holds promise as a method to avoid drug‐induced infertility in male patients about to receive cancer chemotherapy. Complete exclusion of blood flow to the testicle is essential to the success of this technique. We have compared the hand‐held Doppler probe and radionuclide angiography (technetium‐99m pertechnetate) as monitors of testicular blood flow in 10 patients subjected to unilateral TCI. When Doppler evaluation indicated that testicular circulation had been interrupted, the radionuclide angiogram uniformly confirmed and quantified this conclusion. These results validate the hand‐held Doppler as an appropriate tool for assessing testicular blood flow in patients undergoing TCI. © 1993 Wiley‐Liss, Inc.
Multiple breast papillomas in adolescence
Authors: Batchelor John S. , Farah Gassan , Fisher Cyril 
Published: February 2007

AbstractThe condition of multiple breast duct papillomas although relatively common in adult women is not a well recognized clinical entity in adolescent females. The risk of adolescents with this condition developing carcinoma is presently unknown, although in adulthood it is regarded by some authorities as a precancerous condition. We report a case of a 14‐year‐old girl with such a lesion who remains well with no breast abnormalities 2 years after surgery. The clinicopathological features of the condition and the relevant literature are discussed. © 1993 Wiley‐Liss, Inc.
Diagnosis and surgical treatment of small papillary carcinomas of the thyroid gland
Authors: Miki Hitoshi , Oshimo Kazushi , Inoue Hiroyuki , Kawano Muneo , Tanaka Katsuhiro , Komaki Kansei , Uyama Tadashi , Monden Yasumasa 
Published: February 2007

AbstractThe preoperative and pathological findings of 38 cases of small papillary carcinoma of the thyroid gland measuring ⩽10 mm in diameter and 74 cases of large papillary carcinoma measuring more than 10 mm were compared. In the small carcinoma cases, the sensitivity of palpation, ultrasonography, and fine‐needle aspiration biopsy (FNAB) was higher than that of computed tomography and soft tissue roentgenography of the neck. Therefore, palpation, US, and FNAB should be instituted as reliable diagnostic methods, but other examinations seem unsuitable as methods for preoperative qualitative diagnosis. No definite correlation was found between the intraglandular dissemination and the size of the carcinoma, and the frequency of metastasis was relatively high even in the small carcinoma cases. If the patient elects to undergo surgery, subtotal thyroidectomy with lymph node dissection should be performed for small thyroid carcinomas as well as large carcinomas. © 1993 Wiley‐Liss, Inc.
Western blot analysis of glycoproteins bearing lewisa and sialyl‐lewisa antigens in human colorectal mucosa
Authors: Takabayashi Tsukasa , Watanabe Masahiko , Sakurai Yoichi , Sugano Kokichi , Kodaira Susumu , Kitajima Masaki 
Published: February 2007

AbstractGlycoproteins (GPs) bearing Lewisa and sialyl‐Lewisa antigens (Lea, sialyl‐Lea) derived from human colorectal carcinomas and their surrounding non‐neoplastic mucosa (normal mucosa) were analyzed using Western blotting. GPs bearing Lea were detected mainly as segmental bands of Mr 310, 220, 160, and 80 kDa in 80% of the normal mucosa, but these GPs were detected predominantly as broad bands ranging from high to low molecular weight (MW) in 71% of the carcinoma tissues. GPs bearing sialyl‐Lea were detected only in 23% of the normal mucosa and limited on huge MW bands, i.e., more than 400 kDa, whereas these GPs were detected predominantly as broad bands in 49% of the carcinoma tissues. In the cases with lymph node metastasis, the MW of GPs bearing sialyl‐Lea varied over a wide range and were detected as broad bands, compared with the cases without metastasis. In conclusion, the MW of GPs bearing Lea and sialyl‐Lea in normal colorectal mucosa was different from that in colorectal carcinomas. That is, the MWs of GPs bearing Lea varied more in carcinoma tissues, and the GPs bearing sialyl‐Lea from carcinoma tissues had lower MWs than those from normal mucosa. It was, furthermore, suggested that the increased expression of lower MW GPs bearing sialyl‐Lea are associated with an increased metastatic potential of the tumor cells.© 1993 Wiley‐Liss, Inc.
Monoclonal antibodies and their role in modulation of the immune response
Authors: Arlen Myron , Tsang Kwong Y. 
Published: February 2007

AbstractClinical studies in patients having been vaccinated with immunogenic glycoproteins suggest that a monoclonal antibody response is important in helping to induce cell mediated tumor destruction. Such a monoclonal response was noted to characterize the reaction to several different immunogenic antigens administered in an adjuvant setting. The resulting cell mediated reaction appeared to be associated with concomittant antibody dependent cell mediated cytotoxicity (ADCC) and an anti‐idiotype monoclonal response. Both 31.1 and 33.28 protein derived colon carcinoma monoclonal antibodies have been found to be capable of turning on natural killer (NK) cell activity as part of ADCC. In vivo studies with specific antigens to induce an anti‐tumor response have suggested that the mechanism of tumor cell destruction is complex and associated with T‐cell activation, anti‐idiotype production, and complement binding on the tumor membrane. © 1993 Wiley‐Liss, Inc.
Predictors of survival following surgical resection of thymoma
Authors: McCart J. Andrea , Gaspar Laurie , Inculet Richard , Casson Alan G. 
Published: February 2007

AbstractThe aim of this study was to determine the predictors of long‐term survival following surgical resection of thymoma. Forty‐one patients with a histologically proven diagnosis of thymoma were evaluated and treated over a 30‐year period (1961 to 1991) at our institution. Seven patients (Masaoka stage III or IV) were unresectable and were treated by radiotherapy and/or chemotherapy, with an overall 5 year survival of 50%. Thirty‐four patients underwent primary surgical excision of the thymoma, most often through a median sternotomy, with 5‐ and 10‐year survivals of 90%. Complete excision of the thymoma was achieved in 31 patients with a median survival of 54 months vs. 17 months if incomplete. Independent prognostic factors influencing survival were stage, histology, and patients judged to have a benign thymoma at surgery. Although the thymoma was associated with myasthenia gravis (8 patients) and second primary cancers (8 patients), neither factor was associated with overall survival. We conclude that the most significant predictors of long‐term survival of thymoma include complete excision, Masaoka stage I disease, and lymphocytic histology. Multivariate analysis suggested that postoperative chemoradio‐therapy may impact on survival. © 1993 Wiley‐Liss, Inc.
Study of c‐erbB‐2 protein and epidermal growth factor receptor expression and DNA ploidy pattern in colorectal carcinoma
Authors: Nakae Shiro , Shimada Etuji , Urakawa Tomoaki 
Published: February 2007

AbstractCorrelation of c‐erbB‐2 protein (n = 44), epidermal growth factor receptor (EGFR) (n = 41) expression, and DNA ploidy pattern (n = 42) with clinical outcomes of human colorectal cancers was studied. Using monoclonal antibodies against c‐erbB‐2 protein and EGFR, an immunohis‐tochemical study of the expression of c‐erbB‐2 protein and EGFR in frozen tissue sections from the lesion was performed. There was no significant correlation between the expression of c‐erbB‐2 protein and clinicopatho‐logical findings such as, tumor size, histological type, depth of invasion, lymph node metastasis, lymphatic vessel invasion, or venous invasion. However, the incidence of c‐erbB‐2 protein expression in Dukes D was significantly higher (9/10, 90%) than that in Dukes A to C (16/34, 47.1%). Similar tendency was also observed in the expression of EGFR. Aneuploid case was observed in 12 of observed 25 (48%) cases without lymph node metastasis, while it was observed in 16 of 17 cases (94.1%) with lymph node metastasis and there was significant association between DNA ploidy pattern and lymph node metastasis (P< 0.01) and most of the cases (17/20, 85%) were aneuploidy in Dukes C and D. The results above suggest that the expression of c‐erbB‐2 protein or EGFR was associated with distant metastasis, while on the other hand DNA ploidy pattern was correlated with lymph node metastasis. © 1993 Wiley‐Liss, Inc.
The size of regional lymph nodes does not correlate with the presence or absence of metastasis in lymph nodes in rectal cancer
Authors: Kotanagi Hitoshi , Fukuoka Takemi , Shibata Yutaka , Yoshioka Toshiaki , Aizawa Osamu , Saito Yuri , Tur Gennady E. , Koyama Kenji 
Published: February 2007

AbstractWe evaluated the relationship between the size of regional lymph nodes and the presence of metastasis in them in rectal cancer. Of 1,064 lymph nodes in 46 specimens, 133 (13%) were found to have metastases. A half of the positive nodes and most of the negative ones were less than 5 mm in diameter. Therefore, we must find lymph nodes smaller than 5 mm in diameter for assessment of lymph node metastasis. Although positive nodes were larger than negative ones, there was no significant difference. However, when comparing the size of lymph nodes in relation to their location, the epi‐ and pararectal lymph nodes larger than 10 mm in diameter were highly suggestive of metastases, but the size of the lymph node was not a reliable indicator of lymph node metastases in other situations. © 1993 Wiley‐Liss, Inc.
Secretion of vasointestinal peptide by a primary liver tumor with rhabdoid features
Authors: Weyman Christine , Dolson Lynn , Kedar Amos 
Published: February 2007

AbstractA 5‐year‐old child presented with an unresectable liver neoplasm, the histology of which resembled a malignant rhabdoid tumor. Clinical course was unrelenting despite therapy, and the child died four months later. During the course of her illness, she developed watery diarrhea and was found to have a high serum level of vasointestinal peptide (VIP). This is the first report of a childhood tumor with rhabdoid features to secrete VIP. © 1993 Wiley‐Liss, Inc.