bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiparametric evaluation of mediastinal lymph node metastases in clinical T0–T1c stage non-small-cell lung cancers
Authors: Wang Siyang , Bao Xiao , Yang Feixing , Shi Hongcheng 
Published: March 2024

Abstract

OBJECTIVES
This study aimed to determine the predictive factors of lymph node metastases in clinical T0–T1c stage non-small-cell lung cancers, so as to help making surgical strategy.

METHODS
From January 2016 to December 2017, patients with clinical T0–T1c stage non-small-cell lung cancers were retrospectively reviewed. We elucidated the lymph node metastatic incidence and distribution according to the primary tumour radiographic findings and maximal standard uptake values, and extracted the associated clinicopathological factors. Univariable and multivariable logistic regressions were used to identify independent predictive parameters for lymph node metastases. The performance of predictive model was evaluated using receiver operating characteristic analysis.

RESULTS
A total of 517 patients were included. Seventy-two patients had lymph node metastases. Among patients with pure ground-glass nodule and solid component size ≤10 mm, none had any lymph node metastasis. Multivariable logistic regression analysis demonstrated that age, carcinoembryonic antigen level, solid component size, consolidation–tumour ratio and tumour maximal standard uptake values were independent predictors of lymph nodal metastases. Receiver operating characteristic analyses indicated that the area under the curve of predictive model in evaluating lymph node metastases was 0.838 (95% CI 0.791–0.886).

CONCLUSIONS
Younger age, elevated carcinoembryonic antigen level, larger solid component size, higher consolidation–tumour ratio and tumour maximal standard uptake values were associated with lymph node involvement. Employing such a predictive model in the future may affect the surgical option of lymph node excision for patients in cT1 stage non-small-cell lung cancer.
MARS and RNAcmap3: The Master Database of All Possible RNA Sequences Integrated with RNAcmap for RNA Homology Search
Authors: Chen Ke , Litfin Thomas , Singh Jaswinder , Zhan Jian , Zhou Yaoqi 
Published: March 2024

Abstract
Recent success of AlphaFold2 in protein structure prediction relied heavily on co-evolutionary information derived from homologous protein sequences found in the huge, integrated database of protein sequences (Big Fantastic Database). In contrast, the existing nucleotide databases were not consolidated to facilitate wider and deeper homology search. Here, we built a comprehensive database by incorporating the non-coding RNA (ncRNA) sequences from RNAcentral, the transcriptome assembly and metagenome assembly from metagenomics RAST (MG-RAST), the genomic sequences from Genome Warehouse (GWH), and the genomic sequences from MGnify, in addition to the nucleotide (nt) database and its subsets in National Center of Biotechnology Information (NCBI). The resulting Master database of All possible RNA sequences (MARS) is 20-fold larger than NCBI’s nt database or 60-fold larger than RNAcentral. The new dataset along with a new split–search strategy allows a substantial improvement in homology search over existing state-of-the-art techniques. It also yields more accurate and more sensitive multiple sequence alignments (MSAs) than manually curated MSAs from Rfam for the majority of structured RNAs mapped to Rfam. The results indicate that MARS coupled with the fully automatic homology search tool RNAcmap will be useful for improved structural and functional inference of ncRNAs and RNA language models based on MSAs. MARS is accessible at https://ngdc.cncb.ac.cn/omix/release/OMIX003037, and RNAcmap3 is accessible at http://zhouyq-lab.szbl.ac.cn/download/.
Measuring value in health care: lessons from accountable care organizations
Authors: Bao Chenzhang , Bardhan Indranil R 
Published: March 2024

Abstract
Accountable care organizations (ACOs) were created to promote health care value by improving health outcomes while curbing health care expenditures. Although a decade has passed, the value of care delivered by ACOs is yet to be fully understood. We proposed a novel measure of health care value using data envelopment analysis and examined its association with ACO organizational characteristics and social determinants of health (SDOH). We observed that the value of care delivered by ACOs stagnated in recent years, which may be partially attributed to challenges in care continuity and coordination across providers. ACOs that were solely led by physicians and included more participating entities exhibited lower value, highlighting the role of coordination across ACO networks. Furthermore, SDOH factors, such as economic well-being, healthy food consumption, and access to health resources, were significant predictors of ACO value. Our findings suggest a “skinny in scale, broad in scope” approach for ACOs to improve the value of care. Health care policy should also incentivize ACOs to work with local communities and enhance care coordination of vulnerable patient populations across siloed and disparate care delivery systems.
Health literacy and its association with mental and spiritual well-being among women experiencing homelessness
Authors: Rosenblad Andreas Karlsson , Klarare Anna , Rapaport Penny , Mattsson Elisabet , Gaber Sophie Nadia ,   in collaboration with the Women’s Advisory Board for Inclusion Health
Published: March 2024

Abstract
Low health literacy (HL) has been linked to low self-rated health, reduced efficacy of behaviour change, and challenges in preventing, treating, or managing health conditions. People experiencing homelessness are at risk of poor HL; however, few studies have investigated HL in relation to mental and spiritual well-being among people experiencing homelessness in general, or women experiencing homelessness specifically. This cross-sectional study of 46 women experiencing homelessness in Stockholm, Sweden, recruited during the period October 2019–December 2020, aimed to examine how HL was associated with mental and spiritual well-being among women experiencing homelessness. Participants answered questions about socio-demographic characteristics (age, length of homelessness, education) and digital technology (mobile phone/the Internet) use, in addition to Swedish language versions of three questionnaires administered through structured, face-to-face interviews: the Communicative and Critical Health Literacy Scale, the General Health Questionnaire 12 and the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being. Data were analysed using linear regression, which revealed statistically significant associations between HL and mental well-being (p = .009), and between HL and spiritual well-being (p = .022). However, neither socio-demographic characteristics nor digital technology use were significantly associated with HL. In conclusion, promoting HL may improve mental and spiritual well-being in this vulnerable population. An advisory board of women with lived experiences of homelessness (n = 5) supported the interpretation of the findings and emphasised the need to consider HL in relation to basic needs such as ‘housing first’. Moreover, health information and services should be accessible to people with different degrees of HL.
‘The sanctuary of them all’: the politics of manpower and nationality in the armies in exile in the United Kingdom, 1940–4
Authors: Bud G C P 
Published: March 2024

Abstract
Historians have long remarked upon the political significance of the Allied armies from Continental Europe which were established on British soil during the Second World War. Much less attention has been devoted to the implications of maintaining and expanding these forces amid the very particular circumstances of wartime exile. This article examines three aspects of the tension between the imperatives to secure as many men as possible for military service while maintaining the distinctly ‘national’ character of the force as a whole. The failure to mobilize emigrants and expatriates is examined in the first section, while the second section shows how soldiers could use national identities to their own advantage and pass between foreign armies. The final section examines the far-reaching political consequences of the often-obscured ethnic diversity within the ranks, focusing particularly on Jewish soldiers.
Economy-environment-energy performance evaluation of power to hydrogen and power to methane considering renewable energy generation and carbon capture
Authors: Qiao Ning , Zhang Chao , Chen Haidong , Li Qiang , Zhang Jisheng , Tian Hongjie , Jing Hua 
Published: March 2024

Abstract
The integration of multienergy complementary systems has become increasingly prevalent to mitigate the waste of renewable energy. As power-to-gas (P2G) technology advances, converting electricity into gas presents a viable solution for bolstering the reliability of power supplies within integrated energy frameworks. P2G plays a pivotal role in harnessing unused renewable resources, such as wind and solar energy, to produce sustainable power. While numerous studies have explored the advancement of P2G, there remains a lack of comprehensive evaluation of its various component subsystems. This research aims to design a renewable energy power system, augmented by gas-fired generation, assessing the collective advantages of both the power-to-hydrogen (P-H) and power-to-methane (P-M) conversion processes within the P2G infrastructure. It is important to note that the economic potential of P-H conversion is currently constrained by cost factors within existing P2G systems. This study takes into account the dynamics of carbon trading, as well as the hydrogen and methane markets, to compare the economic, environmental and energy-specific benefits of P-H and P-M conversions under different power demand scenarios. The goal is to formulate enhanced strategies to optimize P2G deployment in these varied contexts.
Emotional Blunting in Depression in the PREDDICT Clinical Trial: Inflammation-Stratified Augmentation of Vortioxetine With Celecoxib
Authors: Sampson Emma , Kavakbasi Erhan , Mills Natalie T , Hori Hikaru , Schubert K Oliver , Fourrier Célia , Baune Bernhard T 
Published: March 2024

Abstract

Background
Emotional symptoms are recognized as a key feature in individuals with major depressive disorder. Previously, emotional blunting has been described both as a side effect of antidepressant treatment and as a symptom of depression. Little is known about the change of emotional blunting during antidepressant treatment.

Methods
The PREDDICT trial is a randomized, placebo-controlled, 6-week trial on the augmentation of vortioxetine with the anti-inflammatory agent celecoxib or placebo. Presently we report on exploratory secondary outcomes of changes in emotional blunting in depression assessed with the Oxford Depression Questionnaire (ODQ) total score and subscores from baseline to 8-week, 3-month, and 6-month follow-up assessments.

Results
In the whole group, there was a significant improvement in the ODQ total score and all subscores after 8 weeks. After stratification of participants into the treatment groups, the ODQ total score as well as subscores related to emotional blunting as a symptom of depression (reduction in positive emotions, not caring) improved between baseline and all follow-up time points in both treatment groups. Changes in subscores considered as a side effect of antidepressants (general reduction in emotions, emotional detachment) were inconclusive in both treatment groups. Overall, the placebo-augmented group showed slightly better results in changes of emotional blunting scores than the celecoxib group as did those with elevated inflammation at screening, regardless of treatment group.

Conclusions
This analysis suggests favorable effects of vortioxetine on emotional blunting in both short- and long-term course. The beneficial impact of vortioxetine on emotional blunting was weaker in celecoxib-augmented patients compared with placebo, possibly due to pharmacokinetic interactions.
Clinical Trials Registration: Australian New Zealand Clinical Trials Registry (ANZCTR), ACTRN12617000527369p. Registered on 11 April 2017, http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12617000527369p.
Advancing Local US Transitional Justice Initiatives: A University Partnership Alongside Descendant Communities
Authors: Mann Linda J 
Published: March 2024

ABSTRACT
This article suggests that the ongoing denial by the USA federal government of historical human rights infractions against African Americans and people of African descent led to a proliferation of local transitional justice efforts. Drawing from a university-driven transitional justice project, this article offers an analysis of local initiatives and highlights one of its six transitional justice collaborations. The university project sought to decolonize its structure and approach, drawing on methods of cultural humility, desire-based research and deep listening. This article responds to the success and challenges of decolonizing a transitional justice project within academia. Findings suggested that local initiatives face obstacles due to enduring legacies of harms and silenced histories, necessitating communities to substantiate their claims. Capacity issues and funding are challenged due to centuries of disinvestment. The article offers lessons learned for potential ally organizations who seek to advance transitional justice where government-sponsored redress continues to be denied.
Acute malaria suppresses the B lymphocytic niche in the bone marrow through the alteration of CXCL12-abundant reticular cells
Authors: Lee Michelle Sue Jann , Matsuo-Dapaah Julia , Del Rosario Zorrilla Camila , Omatsu Yoshiki , Nagasawa Takashi , Uemura Shun , Iwama Atsushi , Ishii Ken J , Coban Cevayir 
Published: March 2024

Abstract
Bone marrow is a dynamic organ composed of stem cells that constantly receive signals from stromal cells and other hematopoietic cells in the niches of the bone marrow to maintain hematopoiesis and generate immune cells. Perturbation of the bone marrow microenvironment by infection and inflammation affects hematopoiesis and may affect immune cell development. Little is known about the effect of malaria on the bone marrow stromal cells that govern the hematopoietic stem cell (HSC) niche. In this study, we demonstrate that the mesenchymal stromal CXCL12-abundant reticular (CAR) cell population is reduced during acute malaria infection. The reduction of CXCL12 and interleukin-7 signals in the bone marrow impairs the lymphopoietic niche, leading to the depletion of common lymphoid progenitors, B cell progenitors, and mature B cells, including plasma cells in the bone marrow. We found that interferon-γ (IFNγ) is responsible for the upregulation of Sca1 on CAR cells, yet the decline in CAR cell and B cell populations in the bone marrow is IFNγ-independent. In contrast to the decline in B cell populations, HSCs and multipotent progenitors increased with the expansion of myelopoiesis and erythropoiesis, indicating a bias in the differentiation of multipotent progenitors during malaria infection. These findings suggest that malaria may affect host immunity by modulating the bone marrow niche.
The Metameric Echinoderm
Authors: Turner R L 
Published: March 2024

Synopsis
Animal phyla are distinguished by their body plans, the ways in which their bodies are organized. A distinction is made, for example, among phyla with bodies of many segments (metameric; e.g., annelids, arthropods, and chordates), others with completely unsegmented bodies (americ; e.g., flatworms and mollusks), and a few phyla with bodies of 2 or 3 regions (oligomeric; e.g., echinoderms and hemichordates). The conventional view of echinoderms as oligomeric coelomates adequately considers early development, but it fails to recognize the metameric body plan that develops in the juvenile rudiment and progresses during indeterminate adult growth. As in the 3 phyla traditionally viewed to be metameric (annelids, arthropods, and chordates), metamery, or metamerism, in echinoderms occurs by (1) subterminal budding of (2) serially repeated components of (3) mesodermal origin. A major difference in most echinoderms is that metamery is expressed along multiple body axes, usually 5. The view of a metameric echinoderm might invite new discussions of metazoan body plans and new approaches to the study of morphogenesis, particularly in comparative treatments with annelids, arthropods, and chordates.
121 Unraveling the biology of bovine conceptus elongation
Authors: Lamberti Gabriela , Goldkamp Anna K , Lopes Maria , Bonmann Nicole , Van Rhijn Samuel , Hagen Darren E , Moraes Joao 
Published: March 2024

Abstract
The establishment of pregnancy is a well-regulated process that involves the development of a viable blastocyst, conceptus elongation, maternal recognition of pregnancy, implantation, and the onset of placentation. Pregnancy loss is a major factor limiting reproductive efficiency in livestock species. In cattle, most embryonic losses occur during the first month of gestation. The genetic and epigenetic regulation of embryonic and placental development in ruminants is still poorly understood. To investigate the transcriptome profile of the bovine conceptus during elongation, Angus heifers (n = 8) were superovulated and bred using semen from a proven high-fertility Bos indicus sire. Heifers were flushed on d 14 of gestation using a standard nonsurgical flushing technique. Recovered conceptuses were individually photographed and snap-frozen for total RNA extraction and bulk mRNA sequencing. Recovered conceptuses were classified based on size into ovoid (0.2 – 5mm; n = 6), tubular (&lt;15 mm; n = 7), or filamentous (&gt;16 mm; n = 7). Differentially expressed genes (DEG: FDR &lt; 0.05) were determined using DESeq2 analysis and were functionally annotated using DAVID. The most pronounced transcriptomic changes were identified between the ovoid and tubular stages, with 5,937 DEGs (2,913 upregulated and 3,024 downregulated) and affected pathways were primarily involved in ribosome assembly and rRNA processing. There were 3,966 DEGs (2,069 upregulated and 1,897 downregulated) between the ovoid and filamentous stages, and the most significant pathways were involved in protein translation, embryonic development, and cell cycle. The transition between tubular to filamentous presented 1,435 DEGs (775 upregulated and 660 downregulated) and significant pathways were involved in protein degradation, cell division, cell cycle, protein stabilization, and mRNA splicing. Our findings indicate that the greatest alterations in the transcriptome occur precisely at the initiation of elongation, suggesting that the bovine conceptus undergoes major structural changes at the outset of this process. This major shift in gene expression is presumed to be necessary to support the subsequent exponential growth phase of elongation, required for maternal recognition of pregnancy.
42 Challenges for agricultural social media influencers engagement with young, non-ag adults
Authors: Bennett Samantha P , Martin David , Sawyer Jason T , Rodning Soren P , Mulvaney Don R 
Published: March 2024

Abstract
Segments of society question the welfare of animals in production, whether types of product consumption have a negative impact on personal health, and environmental sustainability of producing livestock. As most Americans are three or more generations removed from production agriculture (American Farm Bureau, 2020), they have minimal incentive to question unsubstantiated information purported by anti-animal agriculture groups. Ag communication strategies often seem to fall short compared with anti-agricultural messages shared throughout the media infosphere. Prominent forms of digital / social media (SM) platforms have infiltrated daily lives of society. With the significance of engagement factors such as likes, comments, shares, and saves on such platforms in mind, our research sought to assess the willingness of SM users to interact with content on Instagram created by agricultural social media influencers (SMIs). Participants (n = 855; ages 18-30 from the U.S. and a non-ag background) were recruited through Prolific and anonymously completed a Qualtrics survey. Quantitative data were responses to questions about willingness to engage with both general content and agriculture-related content. Participants were shown images and narrative content from well-established agricultural SMIs. Participants were surveyed both before and after being shown example image posts of agricultural SMIs. Data were analyzed utilizing SPSS with independent variables consisting of general content versus agricultural content while dependent variables were comprised of the summation of participant engagement type willingness which was operationalized by numerically converting the five-point Likert scale. Results showed differences (P &lt; 0.05) in willingness to engage with agricultural SMI through likes, comments, shares, and saves than with general content. Results imply that agricultural SMIs will have more limited opportunities to facilitate engagement with young adult Instagram users than those that share generalized content. These outcomes reinforce a communication dilemma around SM engagement that focuses on reaching non-ag audiences with image and evidence-based agricultural content.