bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between early childhood outdoor activity and anxiety symptoms in preschoolers
Authors: Wu Jian-Bo , Zhang Yan , Yang Yanni , Qiu Shuang-Yan , Zhou Qiang , Li Jiemin , Zhang Jing-Yu , Xian Danxia , Zhou Fang , Zhao Ziyi , Zhang Yuying , Lu Dali 
Published: March 2024

Abstract
Background
Recently, there has been a decreasing trend in the frequency and duration of outdoor activity among children, which has garnered concern regarding the potential impacts of this decline during mental health in early childhood. Currently, the association between outdoor activity in early childhood and the symptoms of anxiety disorders in preschoolers remains unclear. The purpose of this study was to investigated the association between the frequency and duration of outdoor activities in children aged 0-3 yearsand anxiety symptoms in preschoolers.
Methods
A cross-sectional study was conducted in 2021 using questionnaires, included 69,571 preschoolersresiding in Longhua District, Shenzhen. Data on family social demographics, outdoor activity frequency and duration in children aged 0-3 years, and the anxiety symptoms of preschoolerswere collected through parent-completed questionnaires. The association between early childhood outdoor activity and anxiety symptoms in preschoolerswas analyzed using a binary logistic regression model.
Results
Children 0–1 years of age who were outdoors < 1 times/week had a higher risk of screening positive for anxiety symptoms in preschool age compared with children who were outdoors ≥7 times/week (OR = 2.55, 95% confidence interval(CI): 2.22–2.94). Children in this age group who were outdoors <30 min/session had a higher risk of screening positive for anxiety symptoms in preschool age compared with children who were outdoors ≥120 min/ session (OR = 1.62, 95%CI: 1.38–1.90). Children 1–3 years of age, who were outdoors < 1 time/week had a higher risk of screening positive for anxiety symptoms in preschool age compared with children who were outdoors ≥7 times/week, (OR = 3.10, 95%CI: 2.72–3.54). Children in this age group who were outdoors for < 30 min/sessionhad a higher risk of screening positive for anxiety symptoms in preschool age compared with children who were outdoors time ≥120 min/ session (OR = 2.07, 95%CI: 1.73–2.48).
Conclusion
Lower-frequency and shorter-duration outdoor activity during infancy was associated with a higher risk of anxiety symptoms in preschoolers. A frequency of ≥7 outdoor activity per week and a duration of ≥120 min/session during infancy were associated with lower levels of anxiety symptoms in preschoolers.
Adoption and User Experience of Government of Tanzania-Hospital Management Information System in Meru District Hospital, Arusha, Tanzania: A Qualitative Study
Authors: Edward Lengai , Sukums Felix , Luoga Pankras 
Published: March 2024

Abstract

Background
Electronic medical records (EMRs) have transformed medical information collection, storage, retrieval and use. This led hospitals to invest in EMR adoption and implementation in developed and developing countries. However, EMR implementation is complex, thus calling for assessing the successes of such investment at the various stages of implementation. Therefore, this study aimed to determine the adoption and users’ experience of the Government of Tanzania Hospital Management Information System (GoT-HoMIS) in a primary healthcare facility.
Methodology
A case study employing a qualitative approach was conducted in Meru district hospital in Tanzania. It involved purposive quota sampling of nine hospital managers and healthcare providers. In-depth interviews, observations and document reviews were used. Thematic analysis of qualitative data was used.
Results
The study found that the top-down approach used to adopt GoT-HoMIS limited the preliminary preparations made by the hospital. The availability of a local area network, a reliable electrical power supply, and perceived benefits facilitated the system's use. The use of the system is hindered by partial system implementation, inadequate ICT infrastructure, insufficient ICT knowledge and skills among users, and inadequate management support.
Conclusion
The partial implementation and use of the system in the hospital, inadequate ICT knowledge and skills among users, and insufficient management support in providing funds for ICT infrastructure, training, supervision, and mentorship are the main barriers to effectively using the GoT-HoMIS. Therefore, the study recommended enhancing ICT infrastructure, regular training of users, and strengthening leadership and management support of system implementation.
Reimagining Pathology Reporting for Head and Neck Cancer Resections: 3D Visualizations and Margin Reconciliation
Authors: Yun Jun , Kapustin Danielle , Joseph Justin K. , Su Vivian , Ramirez Ricardo J. , Khan Mohemmed N. , Chai Raymond , Karasick Michael , Wiedmer Christina , Brandwein-Weber Margaret , Urken Mark L. 
Published: March 2024

Abstract
Purpose Surgical pathology reports play an integral role in postoperative management of head and neck cancer patients. Pathology reports of complex head and neck resections must convey critical information to all involved clinicians. Previously, we demonstrated the utility of 3D specimen and defect scanning for communicating margin status and documenting the location of supplemental margins. We introduce a newly-designed permanent pathology report which improves documentation of intraoperative margin mapping and extent of corresponding supplemental margins harvested.Methods A cross-sectional study using human-centered design was implemented to evaluate the existing permanent pathology report with respect to understanding margin status. Pathologists, surgeons, radiation oncologists, and medical oncologists from United States-based medical institutions were surveyed. The results supported a redesign of our surgical pathology template, incorporating 3D specimen / defect scans and annotated radiographic images indicating location of inadequate margins requiring supplemental margins, or indicating frankly positive margins discovered on permanent section.Results Forty-seven physicians completed our survey. Analyzing surgical pathology reports, 28/47 (60%) respondents reported confusion whether re-excised supplemental margins reflected clear margins, 20/47 (43%) reported uncertainty regarding final margin status, and 20/47 (43%) reported the need for clarity regarding the extent of supplemental margins harvested intraoperatively. From this feedback, 61 permanent pathology reports were compiled using newly-designed reporting templates over a 12 month period.Conclusion Feedback from survey respondents led to a redesigned permanent pathology report that offers detailed visual anatomic information regarding intraoperative margin findings and exact location/size of harvested supplemental margins. This reimagined report reconciles frozen and permanent section results and includes annotated radiographic images such that clinicians can discern precise actions taken by surgeons to address inadequate margins.
Pediatric craniopharyngioma with significantly increased intraoperative visual evoked potential amplitude and postoperative visual acuity improvement: a case report
Authors: Oda Yuichi , Amano Kosaku , Chiba Kentaro , Aihara Yasuo , Kawamata Takakazu 
Published: March 2024

Abstract
Visual evoked potential (VEP) is an established modality that allows safe brain tumor resection and preservation of optical function. We herein present a case of a pediatric craniopharyngioma with significant improvement in the VEP amplitude detected during endoscopic transsphenoidal surgery (ETS) and obvious postoperative improvement in visual acuity. A 13-year-old boy presented with visual acuity disturbance in his right eye and was followed-up for 5 months by an ophthalmologist. His visual acuity rapidly worsened, and a suprasellar lesion with calcification was found on brain computed tomography. The patient underwent tumor resection during ETS with intraoperative transcranial VEP monitoring. Gross total tumor resection was achieved without injury to the perforators, including the superior hypophyseal arteries. The VEP amplitude was unstable, and significant waves were not detectable before tumor resection; however, a positive wave was detected after removing most of the tumor and exposing the bilateral optic nerves and optic chiasm. Subsequently, negative and positive VEP waves were continuously detected. Visual acuity improved remarkably on postoperative day 10. This case demonstrated both a significant increase in the intraoperative VEP amplitude and rapid postoperative improvement in visual acuity. We surmised that the preoperative rapid worsening of visual dysfunction, intraoperative increase in the VEP amplitude, and significant postoperative improvement in visual acuity were associated with the compression of the optic nerves by the internal carotid artery, anterior cerebral artery, and tumor.
Effect on Performance, Combustion and Emission Characteristics of Spark Ignition Engine Powered by Premium Level Gasohol- Paraffin Blends With Spark Advancement &amp; Spark Retardment
Authors: Kumbhar Sujit , Khot Sanjay 
Published: March 2024

Abstract
Internal combustion engine emissions from burning fossil fuels, particularly those from petrol engines, are a major factor in change in the climate and the generation of greenhouse gases. For a long time, ethanol has been noticed as a viable alternative to gasoline that might also help to lower pollution levels. In the current experimentation investigations, the engine performance, combustion, and emission characteristics were assessed for the various ethanol-premium gasohol blends with partial addition of alkane’s such as n-pentane, hexane etc. With addition of hexane and n-pentane in premium gasoline and ethanol blends, carbon monoxide (CO) emission decreased by 18% than premium gasohol. The lowest emission were observed for premium gasoline with 40% ethanol and 10% n-pentane. It was observed that addition of hexane and n-pentane hydrocarbons found to be decreased by 15% as compared to premium gasool. Furthermore, with addition of ethanol blending, cylinder pressure decreased. Both unburned hydrocarbon (HC) and Nitrogen oxides (NOx) increased in spark advancement from 21 to 15° bTDC and became minimum for spark timing 21° bTDC. Again, it increased from spark retardment from 21° to 30° bTDC. This was because there was incomplete combustion takes place. But engine emissions decreased with partial addition of alkanes with premium gasoline and 20% ethanol with spark advancement as well as retardment. The brake thermal efficiency of PG + 10% P were found maximum. The oxides of nitrogen (NOx) were found minimum by 25% with addition of ethanol and paraffin in premium gasoline.
Fusion of Two Homoleptic Truncated Tetrahedra into a Heteroleptic Truncated Octahedron
Authors: Zhang Mingming , Liu Haifei , Guo Chenxing , Huang Yujuan , Zhou Zilin , Mu Chaoqun , Zhang Zeyuan , Hou Yali 
Published: March 2024

Abstract
The exploration of novel structures and structural transformation of supramolecular assemblies is of vital importance for their functions and applications. Herein, based on coordination-driven self-assembly, we prepare a neutral truncated tetrahedron and a heteroleptic truncated octahedron, whose structures are unambiguously confirmed by X-ray diffraction analysis. More importantly, the truncated tetrahedron is quantitatively transformed into the truncated octahedron by its fusion with another cationictruncated tetrahedron, as evidenced by fluorescence, mass and NMR spectroscopy. This study not only deepens our understanding of the process of supramolecular fusion but also opens up possibilities for the subsequent preparation of advanced supramolecular assemblies with complex structures and integrated functions.
Association of Patient-Generated Subjective Global Assessment score with surgical outcomes in women with gynecologic cancer
Authors: Jesus Leticia da Silva , Saraiva Danúbia da Cunha Antunes , Marques Bianca Cristina Antunes Alves 
Published: March 2024

Abstract
Objective: To evaluate the association between nutritional status assessed by the Patient-Generated Subjective Global Assessment (PG-SGA) score and surgical complications in patients diagnosed with gynecologic cancer undergoing surgical treatment.
Methods: This was a retrospective study comprising women with gynecologic cancer scheduled for surgical treatment. Nutritional diagnosis was obtained using the PG-SGA, and postoperative outcomes were analyzed, classified, and associated with patients’ nutritional status. For statistical analyses, patients were divided into 2 groups according to PG-SGA score classification. Associations between categorical variables were assessed using the chi-square (χ²) test. Differences in median values of continuous variables were compared using the Mann-Whitney U test. Logistic regression analyses were conducted to determine the likelihood of postoperative complications occurring in patients with higher PG-SGA scores (≥ 4).
Results: The sample consisted of 370 women, with endometrial cancer being the most common cancer. According to PG-SGA, patients with higher scores had longer hospital stays, were more likely to undergo noncurative surgeries, remained in postoperative fasting for a longer duration, and experienced greater postoperative mortality.
Conclusion: Our findings support the use of the PG-SGA as a useful tool for assessing the nutritional status of patients with gynecologic tumors and enabling early intervention in patients at nutritional risk or who are malnourished to optimize nutritional status before surgical intervention and reduce the likelihood of postoperative complications.
The serum metabolome of diffuse axonal injury patients is distinctive and predictive
Authors: Chen Weiliang , Yao Chunyu , Li Shengwen , Chen Rui , Su Wen , Wang Guanjun 
Published: March 2024

Abstract
Background
Metabolism is essential for life maintenance, neurological function and injury repair, yet its role in diffuse axonal injury (DAI) is not fully understood.
Methods
30 DAI patients and 34 non-DAI patients were recruited based on the classification criteria using Magnetic Resonance Imaging (MRI) within 30 days of admission in this exploratory research. Serum samples and clinical parameters were collected upon admission, with the Glasgow Outcome Scale Extended (GOSE) at 6 months post-injury used as the neurological functional outcome. The metabolome was assayed using liquid chromatography-mass spectrometry.
Results
The DAI group and non-DAI group showed significant differences in pupillary light reflex, Glasgow Coma Scale (GCS) score, and Marshall computed tomography (CT) score, as well as in the expression levels of 27 metabolites in serum. Random forest analysis indicated that Lysophosphatidylcholine (LPC) 22:3 sn-2 and carnitine C8:1 greatly contributed to distinguishing DAI patients from non-DAI patients (MeanDecreaseGini: 3.81, 5.16). The combined prediction of DAI using these two metabolites yielded an area under the curve (AUC) of 0.944, which was higher than the combination of clinical parameters.
Conclusions
The serum metabolome of DAI patients is distinctive and has significant value for exploring pathogenesis, determining early diagnosis, and improving long-term neurological function.
Visualization and Bibliometric Analysis of Extracellular Vesicles in Cartilage Regeneration from 2013 to 2023
Authors: Jia Shicheng , Gao Tianze , Zhang Ruiyang , Chen Jiayou , Liang Rongji , Ren Yuxiang , Jiang Xiaocheng , Lin Jianjing 
Published: March 2024

Abstract
Purpose: This study aims to elucidate emerging trends, dynamic advancements, and research focal points in exosome-mediated repair and regeneration of cartilage damage over the past decade, employing a visualization approach.
Methods: A total of 300 research records focusing on the utilization of exosomes in cartilage damage repair and regeneration were systematically gathered from the Web of Science Core Collection (WoSCC) database spanning the years 2013 to 2023. Utilizing R language, VOSviewer, CiteSpace, and GraphpadPrism software, we conducted analyses on the general features, historical progression, literature, and keywords of this research domain. Ultimately, we predicted the research focal points and latest trends in the application of exosomes for cartilage defect repair and regeneration.
Results: The study amassed a total of 300 articles, revealing a steady increase in publications on exosome application in cartilage repair and regeneration over the years. Significantly, contributions from researchers in China, the USA, and Italy have been pivotal in shaping this field. Keywords clustered into nine distinct research subareas, encompassing mesenchymal stem cells (MSCs), osteochondral repair, runx2, drug delivery, mesenchymal stromal cells, unconventional secretion, biological membranes, and regenerative medicine. Notably, keywords such as "osteochondral repair," "runx2," and "drug delivery" featured prominently between 2013 and 2023.
Conclusion: Through a comprehensive review of 300 publications, this bibliometric study provides a detailed overview of exosome-related research in cartilage damage repair and regeneration from 2013 to 2023. The findings contribute to the construction of a knowledge map, illustrating the evolving landscape in this domain. Identifying current trends and potential hotspots, this study offers valuable insights for future researchers in the field.
Design, synthesis and bioactivity evaluation of novel monomethyl auristatin F analogues
Authors: Yang Lisheng , Li Xinglin , Zhao Lei , Hu Wenhao , Qian Yu 
Published: March 2024

Abstract
Monomethyl auristatin F (MMAF), a synthetic analogue of the natural compound dolastatin 10, has garnered significant attention in cancer research due to its high potency in vitro. While previous studies have focused on modifying the N-terminal extension of the amino group and the C-terminal modification of the carboxyl group, there has been limited exploration into modifying the P1 and P5 side chains. In this study, we substituted the valine residue at the P1 position with various natural or unnatural amino acids and introduced triazole functional groups at the P5 side chain. Compounds 11k and 18d exhibited excellent inhibition on tubulin. Additionally, compound 18d demonstrated enhanced cytotoxicity against HCT116 cells compared to the parent compound MMAF, suggesting its potential as a cytotoxic payload for further antibody-drug conjugates (ADC) development.
Thermal equation of state of Li-rich schorl up to 15.5 GPa and 673 K: Implications for lithium and boron transport in slab subduction
Authors: Chen Wei , Zhang Shanrong , Wu Mengzeng , Zhong Qifa , Huang Shijie , Wang Kai , Zhao Wei , Xu Jingui , Fan Dawei , Zhou Wenge 
Published: March 2024

Abstract
The thermal equation of state (EoS) of a natural schorl has been determined at high temperatures up to 673 K and high pressures up to 15.5 GPa using in situ synchrotron X-ray diffraction combined with a diamond-anvil cell. The pressure-volume (P-V) data were fitted to a third-order Birch-Murnaghan EoS with V0 = 1581.45 ± 0.25 Å3, K0 = 111.6 ± 0.9 GPa, and K0′ = 4.4 ± 0.2; additionally, when K0′ was fixed at a value of 4, V0 = 1581.04 ± 0.20 Å3, and K0 = 113.6 ± 0.3 GPa. The V0 (1581.45 ± 0.25 Å3) obtained by the third-order Birch-Murnaghan EoS agrees well with the V0 (1581.45 ± 0.05 Å3) measured at ambient conditions. Furthermore, the axial compression data of schorl at room temperature were fitted to a “linearized” third-order Birch-Murnaghan EoS, and the obtained axial moduli for the a- and c-axes are Ka = 621 ± 9 GPa and Kc = 174 ± 2 GPa, respectively. Consequently, the axial compressibilities are βa = 1.61 × 10–3 GPa–1 and βc = 5.75 × 10–3 GPa–1 with an anisotropic ratio of βa:βc = 0.28:1.00, indicating axial compression anisotropy. In addition, the compositional effect on the axial compressibilities of tourmalines was discussed. Fitting our pressure-volume-temperature (P-V-T) data to a high-temperature third-order Birch-Murnaghan EoS yielded the following thermal EoS parameters: V0 = 1581.2 ± 0.2 Å3, K0 = 110.5 ± 0.6 GPa, K0′ = 4.6 ± 0.2, (∂KT/∂T)P = –0.012 ± 0.003 GPa K–1 and αV0 = (2.4 ± 0.2) × 10–5 K–1. These parameters were compared with those of previous studies on other tourmalines, and the potential factors influencing the thermal EoS parameters of tourmalines were further discussed.
Quality of life of patients with an advanced stage of proliferative diabetic retinopathy after application of various vitrectomy technologies
Authors: Teshev A. F. , Malyshev A. V. 
Published: March 2024

Purpose: A comparative assessment of quality of life (QL) after the use of various vitrectomy (VE) technologies in patients with an advanced stage of proliferative diabetic retinopathy (ASPDR).Material and methods. We examined 132 patients aged 42 to 76 (average age 62.8 ± 2.4 years) who met the classification criteria of ASPDR: impossibility to estimate the area of neovascularization; the fundus of the eye in the posterior pole cannot be seen or can only partialy be seen using an ophthalmoscope; evidence of preretinal or vitreal hemorrhage in the posterior pole with an area of more than 4 optic discs and retinoschisis in the macular zone. All patients were divided into two groups, comparable in age, gender and visual status of the “healthy” eye: the main group (69 eyes), in which VE was performed according to the technique developed by the authors, and the control (63 eyes), in which the traditional VE technique was used. QL was assessed before surgery and 3 months after it using the VFQ-25 and QL-20 questionnaires.Results. QL was found to be higher when the new surgery technique was used: the data of VFA-25 showed a 12.9% increase (p < 0.05) and QL-20 showed a 29.2% increase (p < 0.01), which points to a higher clinical effectiveness of the newly developed surgical treatment technique than that of the traditional technique.Conclusion. The results obtained are related to the ophthalmological features of the developed surgical treatment of ASPDR: combined (phacoemulsification of cataracts + IOL + vitrectomy) one-stage intervention, lack of drainage of subretinal fluid, etc.), medication support (preliminary intravitreal administration of an angiogenesis inhibitor) and anesthesia (intervention under local anesthesia with intravenous sedation). The differences are most effectively identified using the special QL-20 questionnaire.
Improving the daily pan evaporation estimation of long short-term memory and support vector regression models by using the Wild Horse Optimizer algorithm
Authors: Shabani Mohammad , Asadi Mohammad Ali , Fathian Hossein 
Published: March 2024

ABSTRACT

Evaporation is a basic element in the hydrological cycle that plays a vital role in a region's water balance. In this paper, the Wild Horse Optimizer (WHO) algorithm was used to optimize long short-term memory (LSTM) and support vector regression (SVR) to estimate daily pan evaporation (Ep). Primary meteorological variables including minimum temperature (Tmin), maximum temperature (Tmax), sunshine hours (SSH), relative humidity (RH), and wind speed (WS) were collected from two synoptic meteorological stations with different climates which are situated in Fars province, Iran. One of the stations is located in Larestan city with a hot desert climate and the other is in Abadeh city with a cold dry climate. The partial mutual information (PMI) algorithm was utilized to identify the efficient input variables (EIVs) on Ep. The results of the PMI algorithm proved that the Tmax, Tmin, and RH for Larestan station and also the Tmax, Tmin, and SSH for Abadeh station are the EIVs on Ep. The results showed the LSTM–WHO hybrid model for both stations can ameliorate the daily Ep estimation and it can also reduce the estimation error. Therefore, the LSTM–WHO hybrid model was proposed as a powerful model compared to standalone models in estimating daily Ep.