bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stromal neoplasms of the breast: A comparative flow cytometric study
Authors: El‐Naggar Adel K. , Mackay Bruce , Sneige Nour , Batsakis John G. 
Published: February 2007

AbstractWe analyzed 42 mammary spindle cell neoplasms (10 conventional fibroadenomas, 8 giant fibroadenomas, 17 cystosarcoma phyllodes, and 7 stromal sarcomas) by flow cytometry to assess the diagnostic and prognostic relevance of DNA content analysis in the pathologic evaluation of these lesions. Our data indicate that all fibroadenomas were diploid, cystosarcoma phyllodes displayed diploid and aneuploid DNA content irrespective of their histological categorization, and that stromal sarcomas were all aneuploid and clinically aggressive. Diploid cystosarcoma phyllodes were biologically indolent, whereas most of the aneuploid neoplasms killed their hosts (P = 0.03). The present study indicates that a DNA content abnormality is a reliable marker of malignancy in these neoplasms, and it may identify subsets of patients with variable biologic courses within the histopathologic spectrum of cystosarcoma phyllodes.
Primary lymphoma of bone: Experience of 39 cases at the tata memorial hospital, India
Authors: Susnerwala Shabbir S. , Dinshaw Ketayun A. , Pande Subodh C. , Shrivastava Shyam K. , Consalves Mary Ann , Advani Suresh H. , Gopal Ramakrishna 
Published: February 2007

AbstractPrimary lymphoma of bone (PLB) is an uncommon clinical entity and a rare presentation of non‐Hodgkin's lymphoma. At the Tata Memorial Hospital, over a period of 10 years from 1976 to 1985, 39 cases with a diagnosis of PLB were seen. Twenty‐seven cases completed the prescribed treatment and were evaluable for treatment response. Eight patients (21%) presented in clinical stage I (E), four patients (10%) in stage II (E), and 27 patients (69%) in stage IV (E). All of the evaluable patients except two were treated with combination chemotherapy, which consisted of cyclophosphamide, vincristine, and prednisolone in 18 patients, and seven patients received Adriamycin in addition. The majority of patients received six courses of chemotherapy extending over 8 to 12 months. External radiotherapy was given to all except one patient, who had surgery as local treatment. Five patients had generalised relapse, one of which had in addition a local relapse. Five were resistant to treatment. Overall and disease‐free survival by Kaplan‐Meier method at 60 months are 66% and 56%, respectively.
Effective palliation for inoperable esophageal cancer using intensive intracavitary radiation
Authors: Fleischman Erik H. , Kagan A. Robert , Bellotti John E. , Streeter Oscar E. , Harvey James C. 
Published: February 2007

AbstractIn a pilot study between May 1988 and May 1989, ten consecutive patients with advanced esophageal cancer were treated with a short intensive course of intraluminal curietherapy without external beam irradiation at the Kaiser Permanente‐Los Angeles Medical Center. Nine of ten patients achieved effective palliation comparable to that of standard external beam teletherapy from other series. Most patients had already failed other palliative modalities including chemotherapy, laser debridement, dilation, and electrocautery. The duration of response was generally longer than with these techniques. All patients completed therapy, and tolerance was excellent. Intraluminal irradiation is an attractive, effectual therapeutic alternative, especially in patients with advanced local or distant disease unlikely to tolerate 5 to 7 weeks of external beam therapy.
Multicentric adult secretory breast carcinoma: DNA flow cytometric findings, prognostic features, and review of the world literature
Authors: Richard Gene , Hawk J. C. , Baker A. S. , Austin Robert Marshall 
Published: February 2007

AbstractA case of multicentric secretory breast carcinoma in a 39‐year‐old white female is described. Mammograms, DNA analysis, touch preparation cytology, and positive estrogen receptors are reported for the first time in this rare favorable mammary carcinoma. A review of the 33 reported cases with follow‐up in adult females, including the present case, has revealed lymph node metastases in nine (27%), recurrence in four (12%), and distant metastases leading to death in two cases (6%). In patients treated with less than simple mastectomy there has been local recurrence in 4 (33%) of 12 cases and in three of the four cases (75%) greater than or equal to 2.0 cm. Increased size and lack of gross circumscription of the neoplasm and presentation in the adult age group appear to identify cases with an increased risk of disease progression. In patients over 20 years old, especially with neoplasms greater than 2 cm in diameter, modified radical mastectomy has to date achieved the most favorable outcome. Minimal experience (two cases) is available regarding treatment with limited surgery and radiation therapy, and there is no available data regarding possible benefit from adjuvant chemotherapy.
An appraisal of pancreatectomy for advanced cancer of the pancreas based on survival rate and postoperative physical performance
Authors: Miyata Masahiko , Nakao Kazuyasu , Takao Tetsuto , Kuwata Keishi , Nakashima Nobukazu , Dousei Tsutomu , Hayashi Katsuhide , Kawashima Yasunaru 
Published: February 2007

AbstractThe follow‐up results of surgical procedures for cancer of the pancreas at three affiliated hospitals during the past 15 years (1974‐1989) were ret‐rospectively analyzed to evaluate the merit of pancreatectomy in surgical treatment of advanced stages of this disease. Included were 4 cases of stage I, 14 cases of stage II, 19 cases of stage III, 43 cases of localized stage IV, and 35 cases of generalized stage IV. Pancreatectomy was performed in 67 cases; 100%, 92.9%, 89.5%, 67.4%, and 11.4% of the stage I, II, III, localized IV, and generalized IV cases, respectively. For the localized stage IV cases, in which the cancerous lesions were advanced but limited to the peripancreatic region, 29 pancreatectomies, 12 bypass operations, and 2 exploratory laparotomies were performed. This group included 17 curative and 12 noncurative pancreatectomies. The 50% survival periods were 257 days after curative pancreatectomy, 226 days after noncurative pancreatectomy, 120 days after bypass operation, and 33 days after exploratory laparotomy. The difference in overall survival rate between curative and noncurative pancreatectomies was not significant. The overall survival rates after both curative and noncurative pancreatectomies were significantly higher than the rate after bypass operation. The postoperative physical performance status after pancreatectomy was significantly better than after the palliative procedures. No significant difference in the status was found between patients after standard and extended pancreatectomies. There was no signifigant difference in the survival rates or the physical performance status between the pancreatectomy group and the palliative surgery group for the generalized stage IV cases, in which the cancerous lesions extended beyond the peripancreatic region. On the basis of these findings, it is concluded that pancreatectomy extends the postoperative survival period without impairment of the physical performance status in patients with advanced cancer of the pancreas. Even when the pancreatectomy proves to be a noncurative resection, this aggressive surgical approach may be of benefit to this group of patients. It should be noted, however, that pancreatectomy is not beneficial to patients whose lesions have already become generalized.
Immune reactivity in bronchogenic carcinoma and its relation to 5‐year survival rate
Authors: Watanabe Yoh , Shimizu Jyunzo , Hashizume Yasuo , Tsunamura Yukio , Yamada Tetsuji , Iwa Takashi , Sakai Shunnosuke , Murayama Tsugiya , Koshimura Saburo , Saito Motoo 
Published: February 2007

AbstractWe performed a prospective study on the correlation of various parameters of the immune response with the 5‐year survival rate in patients with bronchogenic carcinoma. Parameters were initially examined before starting treatment. Delayed hypersensitivity skin tests, lymphoblastogenesis, natural killer (NK) cell activity, and interleukin‐2 (IL‐2) production were employed to assess immune competence. Each reaction was classified into four or five grades in accordance with intensity; the 5‐year survival rate of the patients showing each grade of the immune response was calculated. A correlation between response before treatment and the survival rate was most clearly noted for lymphoblastogenesis. The skin tests and the NK cell activity showed poorer correlations, and no exact correlation was noted between the IL‐2 production and the immune response.
Renal vein leiomyosarcoma
Authors: Pelton Jeffrey J. , Palazzo Juan P. , Peterson Robert O. , Eisenberg Burton L. 
Published: February 2007

AbstractThe 11th case of primary leiomyosarcoma of the renal vein is reported. Unique features of this case included concomitant resection of an isolated hepatic metastasis, intraoperative radiation therapy, and the use of electron microscopy and immunohistochemical stains in confirming the diagnosis. A review of the previously reported cases shows a tendency toward slow tumor growth and infrequent recurrence (18%). Metastases are common (82%), primarily to the lung and liver. Aggressive surgical resection and adjuvant radiation therapy, including intraoperative radiation therapy, are recommended. Adjuvant chemotherapy should be considered, although its benefits at present are unclear.
Adrenal carcinosarcoma
Authors: Decorato John W. , Gruber Harold , Petti Mario , Levowitz Bernard S. 
Published: February 2007

AbstractThe clinical and pathologic features of a case of adrenal carcinosarcoma are reported. Although synchronous malignancy of the adrenal gland has been described, no case of an adrenal tumor combining both carcinomatous and sarcomatous elements has been previously documented. This neoplasm is extremely aggressive with distant metastasis arising from the sarcomatous component, and rapid progression despite multimodal therapy.
In vivo selection and characterization of a murine mammary tumor subline with high potential for spontaneous lymph node metastasis
Authors: Colombo Lucas L. , Gomez Daniel E. , Puricelli Lydia , Vidal Marìa Del Carmen C. , Ponzio Roberto , De Kier Joffe Elisa Bal 
Published: February 2007

AbstractA transplantable mammary adenocarcinoma, grown in Balb/c mice, with a marked enhancement in its draining lymph node metastatic ability (MM3LN), was obtained through an in vivo procedure from a variant tumor moderately metastatic to lymph nodes (MM3). Both MM3 and MM3LN presented a similar latency and tumor growth rate and reached the same tumor mean diameter at death. MM3LN tumor‐bearing mice exhibited a larger mean survival time. The new variant showed a 2.5‐fold higher incidence of tumor‐draining lymph node metastases than MM3 line, with no differences in the incidence of lung metastases. Morphology as well as cytogenetic and in vitro adhesion properties were studied in order to characterize the new subline. This murine tumor model has potential application in the study of the metastatic process in lymphoid tissue.
Colon carcinoma associated with ureterosigmoidostomy
Authors: Badalament Robert A. , Cirulli Christopher , Zerick William , Lucas Joel G. , Drago Joseph R. 
Published: February 2007

AbstractA patient developing a colonic adenoma 38 years following ureterosigmoidostomy is presented. The mechanisms of neoplastic transformation associated with ureterosigmoidostomy is now better understood. This knowledge is being applied to develop modifications both of the surgical technique and the management of patients with this form of urinary diversion, and is a subject of discussion.
Effects of FUdR on primary‐cultured colon carcinomas metastatic to the liver
Authors: Schroy Paul C. , Cohen Alfred , Winawer Sidney J. , Friedman Eileen A. 
Published: February 2007

AbstractHepatic arterial infusion of fluorodeoxyuridine (FUdR) has demonstrated efficacy in the treatment of metastatic colorectal carcinoma of the liver, In this study, the direct cytotoxic effect of FUdR was measured on ten metastatic and two primary‐site colorectal carcinomas in a primary culture assay system. Overall, clinically achievable concentrations of FUdR (0.4 to 4 μM) induced partial cell kill in 75% of tumors, including a > 50% reduction in viable tumor cell number in only two tumors and <50% in the remaining seven. Total cell kill was not observed in any tumor. Three tumors were resistant to these FUdR concentrations. Tumor sensitivity correlated with the size of the tumor growth fraction. Increasing the exposure time to FUdR from 3 to 7 days approximately doubled the magnitude of the response. 5‐Fluorouracil and cisplatin, at clinically achievable concentrations, were more toxic to metastatic tumor cells than FUdR. Because of the limited chemosensitivity of metastatic colorectal tumor cells to FUdR in vitro, we postulate that other mechanisms besides direct cytotoxicity contribute to the clinical efficacy of FUdR in vivo.
Cryoprobe as a “handle” for resection metastatic liver tumors
Authors: Welling Richard E. , Lamping Kathleen 
Published: February 2007

AbstractResection of metastatic liver tumors can be a difficult and risky procedure. Using a cryoprobe as a “handle” can greatly facilitate resection by providing a taut surface for transection and improving visualization of ductal and vascular structures. In addition, this technique may decrease the risk of contaminating surrounding tissues with cancer cells, and may inhibit tumor recurrence within the margins of resection.
Extended neck dissection
Authors: Shaha Ashok R. 
Published: February 2007

AbstractFrom the time Crile described radical neck dissection in 1906, this surgical procedure became popular in the management of metastatic cancer in the neck. Over the past two decades, the modified neck dissection has been effectively utilized for conservation of function and cosmesis while achieving the same oncologic goals. However, there are several instances where the above standard procedures are not adequate for resection of malignant tumors. Although there is a definite trend toward conservation procedures, extended neck dissection is often necessary especially in patients with N2 and N3 disease. Apart from the standard structures removed in radical neck dissection, the other structures removed in extended neck dissection include skin, the digastric muscle, hypoglossal nerve, vagus nerve, sympathetic chain, ramus mandibularis, carotid artery, tracheo‐esophageal nodes, etc.Over the past seven years, we have performed 40 extended neck dissections. All the patients had N2 or N3 disease in the neck. Nine patients had unknown primaries. Thirteen patients had their primary tumors in the oral cavity and 11 in the laryngopharynx. Five patients had primary tumor in the salivary glands and two patients had metastatic melanoma. Patients who underwent extensive skin excision had pectoralis myocutaneous flap reconstruction.All patients received postoperative radiation therapy. One patient died of cardiac problems 4 weeks after operation. Local control was achieved in 70%. The most difficult region for local control was the disease behind the mastoid process, and the most difficult problems were patients with involvement of the subdermal lymphatics. Our data suggests that there are definite situations where extended neck dissection is indicated with satisfactory local control of the nodal disease.
Gamma‐detecting probe and autoradiographic studies of radiolabeled antibody B72.3 in CX‐1 colon xenografts
Authors: Sampsel James W. , Hinkle George , Nieroda Carol , Ignaszewski Judi , Thurston Marlin , Martin Edward W. 
Published: February 2007

AbstractNude mice bearing CX‐1 colon tumors were injected with 50 μCi 125I‐labeled monoclonal antibody (MAb) B72.3. Radioactivity in tumors was studied with the gamma detecting probe (GDP) on days 1, 3, 7, and 10 after MAb injection. On each day, two mice were sacrificed and sections were examined with autoradiography (ARG), immunoperoxidase methods (IMP), and routine stains.Mean probe counts showed increasing tumor to background ratios and ARG demonstrated a rogressive increase in radionuclide in the tumors. The distribution of 125I was primarily around the vascular spaces on day 1, but by day 3 and progressively it appeared in tumor gland lumina and necrotic areas. A regional correlation was shown between radionuclide in vascular spaces and its sequestration in tumor elements.
Carcinoid tumors
Authors: Nwiloh Jonathan O. , Pillarisetty Sitaram , Moscovic Edward A. , Freeman Harold P. 
Published: February 2007

AbstractThe authors carried out a retrospective study of 32 patients (23 M, 9 F) with carcinoid tumors who were diagnosed and treated at Harlem Hospital Center, New York, from 1967 to 1988. All the patients were black and the commonest sites were the ileum (28.1%), rectosigmoid and rectum (21.9%), and the appendix and lung (15.6% each). Metastasis correlated with site, size, and depth of the primary tumor and occurred in 12 patients (38%), most frequently to the regional lymph nodes and liver. Carcinoid syndrome developed in 12.5% (3 F, 1 M). Surgical resection for cure or palliation was the mainstay of treatment. Overall 5 year survival rate was 66%, and for those with metastases was 0%. The poorer survival rates are probably related to the socioeconomic status of our patient population. The only observed racial difference compared to other series is the preponderance of males, and the disproportionately higher ratio of females with the carcinoid syndrome.
Comparison of characteristics of esophageal squamous cell carcinoma associated with head and neck cancer and those with gastric cancer
Authors: Kuwano Hiroyuki , Morita Masaru , Tsutsui Shin‐Ichi , Kido Yuichiro , Mori Masaki , Sugimachi Keizo 
Published: February 2007

AbstractIn ongoing reviews of 339 patients with surgically treated primary squamous cell carcinoma, there were 19 (5.6%) with concurrent gastric cancer and 11 (3.2%) with head and neck cancer. The incidences of intra‐esophageal multiple occurrence of esophageal cancer are 27.3% and 26.3% in those with associated head and neck cancer and gastric cancer, respectively, and higher than 7.1% in those without such a concurrent cancer. There was no difference in the clinicopathological characteristics of those with concurrent head and neck and gastric cancers, except for the higher incidence of metachronous occurrence in the former. These findings suggest that, in cases of esophageal cancer associated with concurrent head and neck cancer and gastric cancer, intraesophageal multiplicity of the esophageal carcinoma is frequent and that preoperative serial evaluations is most important to design treatment and estimate the prognosis.
Immune competent cells of regional lymph nodes in colorectal cancer patients: I. Flow cytometric analysis of lymphocyte subpopulation
Authors: Adachi Wataru , Sugenoya Akira , Iida Futoshi 
Published: February 2007

AbstractLymphocyte subpopulations of the regional lymph nodes in 20 colorectal cancer patients were measured by flow cytometry to analyze nodal lymphocytes phenotypically. Eleven patients with cholelithiasis were used as controls. Comparison of lymphocyte subpopulations between colorectal cancer and control groups revealed a significantly increased rate of Leu‐12+ cells in the cancer patients. Furthermore, a significant increase of Leu‐3a+ Leu‐8− cells and a significant decrease of Leu‐3a+ Leu‐8+ cells were also found in the paracolic nodes of the cancer patients. However, Leu‐2a+ Leu‐15− cells were not different between the both groups. Meanwhile, in the cancer patients, the rates of Leu‐4+, Leu‐3a+, and Leu‐3a+ Leu‐8− cells were higher in the paracolic nodes compared with the intermediate nodes. Additional investigation of the correlation between clinicopathological features of the tumors and lymphocyte subpopulations, showed that Leu‐12+ cells were related to the tumor size and Leu‐2a+ 15− cells related to the histopathological type. The foregoing results indicate that the rates of both B and helper T cells, which may specifically participate in the antibody production, increase in the regional lymph nodes of colorectal cancer patients.
Characterization and histopathological correlation of cytosol proteins of benign and malignant breast tumors
Authors: Khanna Hari D. , Das Debasis , Kashyap Jagadish N. , Gupta Saroj , Khanna Sushila 
Published: February 2007

AbstractSignificant differences in cytosol protein level exist between normal/benign and cancerous breast tissues. There is a positive correlation between the cytosol protein level and histological grade of carcinoma. Well‐differentiated carcinoma have a lower value of cytosol protein than poorly differentiated carcinoma. In slab gel electrophoregrams, the total numbers of bands are almost identical in normal, benign, and malignant conditions. In addition, 37 Kd protein band is consistently present in malignant cases and always absent in normal or benign cases. More extensive biophysical examination of this band may provide further insight into the protein alterations in cancer cells at the molecular level.
Surgical resection of a solitary liver metastasis in a 46‐year‐old patient with a malignant thymoma
Authors: Marasco William J. , Hergreuter Charles A. , Pritchard Elaine , O'Hara Carl J. , Steele Glenn D. 
Published: February 2007

AbstractClinical history, surgical treatment, and pathologic findings of a solitary liver metastasis of a malignant thymoma in a 46‐year‐old female are reported. An extensive literature review has revealed no record of surgical resection of liver metastasis in a patient with invasive thymoma.
Endometrial carcinoma: A pathologic evaluation of 142 cases with and without associated endometrial hyperplasia
Authors: Ayhan Ali , Yarali Hakan , Ayhan Ayşe 
Published: February 2007

AbstractThe association of some cases of endometrial carcinoma (EC) with hyperestrogenism is well known. The prognostic significance of concomitant endometrial hyperplasia (EH) in EC were evaluated in 142 patients with clinical stage I EC in whom lymph node assessment was carried out in 121 patients. The presence of EH was significantly associated with better differentiated tumor having lesser degrees of myometrial invasion, low segment‐adnexal‐lymphovascular space and pelvic/para‐aortic lymph node involvement. However, the presence of EH was not significantly associated with the less virulent histologic subtypes. The possible existence of two types of EC–a hormonal‐dependent EC associated with EH, and an independent EC not associated with EH–is discussed and the prognostic significance of concomitant EH stressed.
Correlation between estrogen receptor status and histological malignancy in human breast cancer
Authors: Komaki Kansei , Mori Toshiaki , Morimoto Tadaoki , Sasa Mitsunori , Monden Yasumasa , Ii Kunio 
Published: February 2007

AbstractSixty‐two breast carcinoma patients underwent mastectomy and were analyzed for correlations between estrogen receptor (ER) status of the tumor and the histological findings of tumor, age, nodal status, and tumor size. An immunocytochemical assay for the detection of ER in breast carcinomas was used to evaluate the staining intensity index (SII) of the ER level of the tumors, which was calculated from the staining intensity of cancer cells and the percentage of ER‐positive cancer cells. The histological differentiation of carcinomas showed a strong correlation with the SII. A statistically significant (F = 10.580, P < 0.0005) negative correlation was found between the grade of malignancy and the SII. Patients under 50 years of age tended to have a lower SII, whereas patients over 49 years of age tended to have a higher SII. The tumor size, and nodal status showed no correlations with the SII in any of the patients. The histological differentiation of the tumor cells showed a strong correlation with the heterogeneity of the distribution of ER‐positive cells in breast cancers.