bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forecasting High Wind Events in the HRRR Model over Wyoming and Colorado. Part I: Evaluation of Wind Speeds and Gusts
Authors: Collins Ethan , Lebo Zachary J. , Cox Robert , Hammer Christopher , Brothers Matthew , Geerts Bart , Capella Robert , McCorkle Sarah 
Published: March 2024

Abstract
Strong wind events cause significant societal damage ranging from loss of property and disruption of commerce to loss of life. Over portions of the United States, the strongest winds occur in the cold season and may be driven by interactions with the terrain (downslope winds, gap flow, and mountain wave activity). In the first part of this two-part series, we evaluate the High-Resolution Rapid Refresh (HRRR) model wind speed and gust forecasts for the 2016–22 winter months over Wyoming and Colorado, an area prone to downslope windstorms and gap flows due to its complex topography. The HRRR model exhibits a positive bias for low wind speeds/gusts and a large negative bias for strong wind speeds/gusts. In general, the model misses many strong wind events, but when it does predict strong winds, there is a high false alarm probability. An analysis of proxies for surface winds is conducted. Specifically, 700- and 850-mb (1 mb = 1 hPa) geopotential height gradients are found to be good proxies for strong wind speeds and gusts at two wind-prone locations in Wyoming. Given the good agreement between low-level height gradients and surface wind speeds yet a strong negative bias for strong wind speeds and gusts, there is a potential shortcoming in the boundary layer physics in the HRRR model with regard to predicting strong winds over complex terrain, which is the focus of the second part of this two-part study. Last, the sites with the largest strong wind speed bias are found to mostly sit on the leeward side of high mountains, suggesting that the HRRR model performs poorly in the prediction of downslope windstorms.

Significance Statement
We investigate the performance of the High-Resolution Rapid Refresh (HRRR) model with respect to strong wintertime wind speeds and gusts over the complex terrain of Wyoming and Colorado. We show that the overall performance of the HRRR model is low with regard to strong wind speed and wind gust forecasts across the investigated winter seasons, with a large negative bias in predicted strong wind speeds and gusts and a small positive bias for weak wind speeds and gusts. The largest biases are found to be on the leeward side of high mountains, indicating poor prediction of downslope winds. This study also utilizes National Weather Service forecasting metrics to understand their performance with respect to strong wind forecasts, and we find that they provide skill in forecasting these events.
Comparing clinical outcomes of hybrid coronary revascularization with open coronary artery bypass in patients with multi-vessels lesions
Authors: Lin Ji , Li Guang , Ji Yuan , Xu Yi , Liu Shuo , Qu Zheng , Li Ping , You Bin 
Published: March 2024

Objectives Hybrid coronary revascularization (HCR) involves the use of minimally invasive direct coronary artery bypass grafting (CABG) to treat the left anterior descending artery (LAD), and percutaneous coronary intervention to treat non-LAD vessels. We reported the results of a comparative analysis between HCR and off-pump CABG via sternotomy (OPCABG). Methods Data were retrospectively collated from patients who underwent HCR or OPCABG for multivessel coronary artery disease between 2011 and 2022. Propensity score-based matching was performed to reduce the selection bias. The Comparisons of cardiac-related death, major adverse cardiac and cerebrovascular events (MACCE), and repeat revascularization were performed by Kaplan-Meier analysis or the Fine-Gray test. Results After matching, the baseline characteristics were well-balanced between the two groups with 91 patients per group. There was no significant difference in operative mortality rate (1.1% for HCR vs2.2% for OPCABG, p = 1.000). However, patients undergoing HCR required a significantly lower rate of blood product transfusions ( p < .001) and experienced significantly fewer pulmonary complications than OPCABG patients ( p < .001). At 10 years, the incidences of cardiac-related death, MACCE and repeat revascularization did not differ significantly between the two groups (9.5% vs11.5%, p = .277; 4.7% vs12.3%, p = .361; 1.2% vs2.5%, p = .914, respectively). Conclusions For patients with multi-vessel lesions, HCR was comparable to OPCABG in long-term outcomes such as cardiac-related death, MACCE, and the durability of grafts. Additionally, HCR was better than OPCABG in perioperative outcomes. HCR may be an alternative therapy for OPCABG in patients with multi-vessel coronary artery disease.
Knee Joint Line Obliquity With Adaptational Hip and Ankle Joint Orientation After Medial Open Wedge High Tibial Osteotomy
Authors: Jun June-Bum , Lee Sung-Sahn , Oh Juyong , Lee Dae-Hee 
Published: March 2024

Background: Time-dependent postoperative changes in knee joint line obliquity (KJLO) and subsequent adaptational changes in the hip and ankle joints have not been fully proven after medial open wedge high tibial osteotomy (MOWHTO). Purpose: To investigate the serial postoperative changes in KJLO and subsequent adaptational changes in the hip and ankle joints over time after MOWHTO. Study design: Case series, Level of evidence, 4. Methods: A total of 92 patients who underwent MOWHTO between April 2015 and December 2020 were evaluated. Radiographic parameters, including KJLO, ankle joint line obliquity (ALO), hip abduction angle (HAA), joint line convergence angle, weightbearing line ratio, and hip-knee-ankle angle, were analyzed in time sequence (preoperatively and 3, 6, 12, and 24 months postoperatively). Repeated-measures analysis of variance and post hoc analysis were used to demonstrate alterations and the statistical significance of KJLO and other related radiographic parameters over time. Results: The mean KJLO values were –1.9°, –2.1°, –2.7°, and –3.2° at 3, 6, 12, and 24 months postoperatively, respectively, indicating that there was consistent increase in valgus tilting of KJLO from 6 to 24 months ( P < .001 for both 6-12 months and 12-24 months). ALO and HAA showed significant changes from 6 to 12 months (ALO, P < .001; HAA, P = .002), but not between 12 and 24 months (ALO: –3.0°, –2.7°, –1.9°, and −1.6°; HAA: –0.8°, –0.9°, –1.5°, and −1.8° at 3, 6, 12, and 24 months, respectively). The mean joint line convergence angle, weightbearing line ratio, and hip-knee-ankle angle did not change significantly from 3 months to 24 months postoperatively. Conclusion: There was a consistent increase in valgus tilting of the postoperative KJLO from 6 to 24 months after MOWHTO. The adaptive ALO and HAA significantly changed between 6 and 12 months and were maintained until 24 months after MOWHTO. It is necessary to consider the adaptive change when hip or ankle surgery is planned within this period.
Using combination of albumin to fibrinogen ratio and prognostic nutritional index model for predicting disease activity in patients with systemic lupus erythematosus
Authors: Zhao Hongshuai , Huang Zikun , Wang Shiqian , Fu Peng , Fu Biqi , Guo Yang , Li Junming , Luo Qing 
Published: March 2024

Background: Systemic lupus erythematosus (SLE) is chronic autoimmune disease with multiple organ damage and is associated with poor prognosis and high mortality. Identification of universal biomarkers to predict SLE activity is challenging due to the heterogeneity of the disease. This study aimed to identify the indicators that are sensitive and specific to predict activity of SLE. Methods: We retrospectively analyzed 108 patients with SLE. Patients were categorized into SLE with activity and without activity groups on the basis of SLE disease activity index. We analyzed the potential of routine and novel indicators in predicting the SLE activity using receiver operating characteristic curves and multivariate logistic regression. The Spearman method was used to understand the correlation between albumin to fibrinogen ratio (AFR), prognostic nutritional index (PNI), AFR-PNI model and disease activity. Results: SLE with activity group had higher ESR, CRP, D-dimer, fibrinogen, CRP to albumin ratio, positive rate of anti-dsDNA and ANUA, and lower C3, total bilirubin, total protein, albumin, albumin/globulin, creatinine, high density liptein cholesterol, hemoglobin, hematocrit, lymphocyte count, positive rate of anti-SSA, AFR, PNI than SLE without activity. A further established model based on combination of AFR and PNI (AFR-PNI model) showed prominent value in distinguishing SLE with activity patients from SLE without activity patients. In addition, the sensitivity and specificity of AFR-PNI model + anti-dsDNA combination model were superior to AFR-PNI model. AFR and PNI were risk factors for SLE activity. Moreover, AFR+PNI model correlated with disease activity and AFR-PNI model was associated with fever, pleurisy, pericarditis, renal involvement. Conclusion: These findings suggest that predictive model based on combination of AFR and PNI may be useful markers to identify active SLE in clinical practice.
Stories to Prevent Cancer: A Pilot Study Using Cancer Survivor Narratives to Increase Human Papillomavirus Vaccine Intentions
Authors: Bufalini Chelsea M. , Kraschnewski Jennifer L. , Riley Timothy D. , Wile Kevin , Spanos Katherine , Wong Ashley , Myrick Jessica Gall , Schaefer Eric W. , Calo William A. 
Published: March 2024

Introduction Human papillomavirus (HPV) vaccination rates are lower than other recommended adolescent vaccines. Cancer survivor narratives are used to promote cancer prevention and control, but little is known about their impact on adolescent HPV vaccination. Objective This pilot study explored the feasibility and effects of a video education intervention using a cancer survivor narrative to improve parents’ attitudes toward and intentions to get the HPV vaccine. Methods This study utilized a one-group design; participants completed a pre-intervention survey, watched the video before attending their sons’ wellness visits, and completed a post-intervention survey within one week of their appointment. Using the narrative persuasion framework, we developed a 4-minute video of a local HPV-related cancer survivor to promote the HPV vaccine as cancer prevention. We recruited 37 participants between June and October 2020. Participants were parents of males ages 9-17 who had not yet initiated HPV vaccination. Results After the video, more parents agreed that HPV vaccination is safe (pre: 66% vs. post: 82%; P = .045) and that their child’s chances of getting HPV-related cancer in the future are high (pre: 24% vs. post: 46%; P = .014). Overall, 91% of parents felt the cancer survivor story helped them understand the risks of HPV cancers, and 52% said the story influenced their decision to start HPV vaccination for their child. Conclusions Our findings suggest that cancer survivor narratives influence parents’ vaccine opinions and understanding of their child’s risk of HPV infection, leading to increased parental intent to get the HPV vaccine for their adolescent males.
Developing initial programme theories for a realist synthesis on digital clinical consultations in maternity care: contributions from stakeholder involvement
Authors: Evans Catrin , Clancy Georgia , Evans Kerry , Booth Andrew , Nazmeen Benash , Timmons Stephen , Sunney Candice , Clowes Mark , Jones Nia Wyn , Spiby Helen 
Published: March 2024

Background: The COVID pandemic prompted an increase in the use of digital clinical consultations (telephone or video calls) within midwifery and nursing care. This paper reports on a realist review project related to maternity care that seeks to illuminate for whom such consultations can safely and acceptably be used, how, for what purposes and in what contexts. Aims: This paper addresses the first phase of a realist enquiry – initial programme theory development – focusing particularly on the role of stakeholder involvement (including digital transformation leaders, midwives, obstetricians, service users and community organisations). Methods: Three sub-stages of initial programme theory development are described highlighting the contribution of stakeholder groups to each stage: (i) consultation to focus the review question, (ii) focused searching and (iii) further consultation. Results: Realist literature searching strategies yielded limited theory-rich evidence on digital consultations. Stakeholders provided essential additional contributions resulting in the development of 13 initial programme theories and a conceptual framework. Conclusions: More research on the implementation of virtual midwifery/nursing consultations is needed. Nursing/midwifery digital researchers should involve stakeholders to help shape research priorities, deepen contextual understanding and sense-check emerging findings.
Nusinersen therapy changed the natural course of spinal muscular atrophy type 1: What about spine and hip?
Authors: Yasar Niyazi Erdem , Ozdemir Guzelali , Uzun Ata Elif , Ayvali Mustafa Okan , Ata Naim , Ulgu Mahir , Dumlupınar Ebru , Birinci Suayip , Bingol Izzet , Bekmez Senol 
Published: March 2024

Purpose: Spinal muscular atrophy type 1 has a devastating natural course and presents a severe course marked by scoliosis and hip subluxation in nonambulatory patients. Nusinersen, Food and Drug Administration-approved spinal muscular atrophy therapy, extends survival and enhances motor function. However, its influence on spinal and hip deformities remains unclear. Methods: In a retrospective study, 29 spinal muscular atrophy type 1 patients born between 2017 and 2021, confirmed by genetic testing, treated with intrathecal nusinersen, and had registered to the national electronic health database were included. Demographics, age at the first nusinersen dose, total administrations, and Children’s of Philadelphia Infant Test of Neuromuscular Disorders scores were collected. Radiological assessments included parasol rib deformity, scoliosis, pelvic obliquity, and hip subluxation. Results: Mean age was 3.7 ± 1.1 (range, 2–6), and average number of intrathecal nusinersen administration was 8.9 ± 2.9 (range, 4–19). There was a significant correlation between Children’s of Philadelphia Infant Test of Neuromuscular Disorders score and the number of nusinersen administration ( r = 0.539, p = 0.05). The correlation between Children’s of Philadelphia Infant Test of Neuromuscular Disorders score and patient age ( r = 0.361) or the time of first nusinersen dose ( r = 0.39) was not significant ( p = 0.076 and p = 0.054, respectively). While 93.1% had scoliosis, 69% had pelvic obliquity, and 60.7% had hip subluxation, these conditions showed no significant association with patient age, total nusinersen administrations, age at the first dose, or Children’s of Philadelphia Infant Test of Neuromuscular Disorders scores. Conclusion: Disease-modifying therapy provides significant improvements in overall survival and motor function in spinal muscular atrophy type 1. However, progressive spine deformity and hip subluxation still remain significant problems in the majority of cases which would potentially need to be addressed.
Promotive and Buffering Effects of Protective and Compensatory Experiences on Mental Health and Adjustment in Young Adults
Authors: Ratliff Erin L. , Jespersen Jens E. , Addante Samantha , Watrous Jennifer N. H. , Morris Michael , Beasley Lana O. , Ciciolla Lucia , Hays-Grudo Jennifer , Morris Amanda S. 
Published: March 2024

Adverse childhood Experiences (ACEs) are considered a major public health crisis. Protective and Compensatory Experiences (PACEs) may help to ameliorate the effects of ACEs on young adult well-being. This study examined the moderating role of childhood PACEs on the effects of ACEs on depression, anxiety, substance use, and emotion regulation (ER) difficulties in a sample of 550 (73% female, m age = 20 yrs.) undergraduate students. ACEs were associated with greater symptoms of anxiety and depression, substance use, and ER difficulties whereas PACEs were associated with fewer symptoms of depression and anxiety, substance use, and ER difficulties. Protective and compensatory experiences significantly moderated the relationship between ACEs and depression, such that greater PACEs weakened the relationship between ACES and depression. Protective and compensatory experiences did not significantly moderate relationships between ACEs and anxiety, substance use, or ER difficulties. These findings suggest PACEs promote adjustment in young adults and can buffer the deleterious effects of ACEs.
The crystal structure of charmarite – the first case of a 11 × 11 Å superstructure mesh in layered double hydroxides
Authors: Zhitova Elena S. , Zolotarev Andrey A. , Kasatkin Anatoly V. , Sheveleva Rezeda M. , Krivovichev Sergey V. , Pekov Igor V. , Bocharov Vladimir N. 
Published: March 2024

AbstractCharmarite, Mn4Al2(OH)12CO3⋅3H2O, is a hydrotalcite supergroup member (or layered double hydroxide, LDH) with a previously unknown crystal structure and a Mn2+-analogue of quintinite (commonly erroneously reported as ‘2:1 hydrotalcite’). The single-crystal X-ray diffraction (XRD) data were obtained from the specimen from Mont Saint-Hilaire, Québec, Canada and are best processed in the space group P$\bar{3}$, a = 10.9630(4), c = 15.0732(5) Å and V = 1568.89(12) Å3. The crystal structure has been solved by direct methods and refined to R1 = 0.0750 for 3801 unique reflections with Fo > 2σ(Fo). The charmarite structure has long-range periodicity in the xy plane due to $2\sqrt 3$a’ × $2\sqrt 3$a’ scheme (or 11 × 11 Å) determined for LDHs for the first time (where a’ is a subcell parameter ≈ 3.2 Å). This periodicity is produced by the combination of two superstructures formed by: (1) Mn2+ and Al3+ ordering in the metal-hydroxide layers [Mn4Al2(OH)12]2+ according to the $\sqrt 3$a’ × $\sqrt 3$a’ pattern and (2) the (CO3)2– ordering according to the 2a’ × 2a’ pattern in the [CO3(H2O)3]2– interlayer sheet in order to avoid close contacts between adjacent carbonate groups. The $2\sqrt 3$a’ × $2\sqrt 3$a’ superstructure is an example of the adaptability of the components of the interlayer space to the charge distribution of the metal-hydroxyl layers. The Mn2+ and Al3+ cations have a large difference in size, which apparently leads to the considerable degree of their order as di- and trivalent cations resulting in a higher degree of statistical order of the interlayer components. Both powder and single-crystal XRD data show that the samples studied belong to the hexagonal branch of two-layer polytypes (2T or 2H) with d00n ≈ 7.57 Å. The chemical composition of the samples studied is close to the ideal formula. The Raman spectrum of charmarite is reported and the band assignment is provided.
DNA damage response defects in hematologic malignancies: mechanistic insights and therapeutic strategies
Authors: Kwok Marwan , Agathanggelou Angelo , Stankovic Tatjana 
Published: March 2024

Abstract
The DNA damage response (DDR) encompasses the detection and repair of DNA lesions and is fundamental to the maintenance of genome integrity. Germ line DDR alterations underlie hereditary chromosome instability syndromes by promoting the acquisition of pathogenic structural variants in hematopoietic cells, resulting in increased predisposition to hematologic malignancies. Also frequent in hematologic malignancies are somatic mutations of DDR genes, typically arising from replication stress triggered by oncogene activation or deregulated tumor proliferation that provides a selective pressure for DDR loss. These defects impair homology–directed DNA repair or replication stress response, leading to an excessive reliance on error-prone DNA repair mechanisms that results in genomic instability and tumor progression. In hematologic malignancies, loss-of-function DDR alterations confer clonal growth advantage and adverse prognostic impact but may also provide therapeutic opportunities. Selective targeting of functional dependencies arising from these defects could achieve synthetic lethality, a therapeutic concept exemplified by inhibition of poly-(adenosine 5′-diphosphate ribose) polymerase or the ataxia telangiectasia and Rad 3 related-CHK1-WEE1 axis in malignancies harboring the BRCAness phenotype or genetic defects that increase replication stress. Furthermore, the role of DDR defects as a source of tumor immunogenicity, as well as their impact on the cross talk between DDR, inflammation, and tumor immunity are increasingly recognized, thus providing rationale for combining DDR modulation with immune modulation. The nature of the DDR–immune interface and the cellular vulnerabilities conferred by DDR defects may nonetheless be disease-specific and remain incompletely understood in many hematologic malignancies. Their comprehensive elucidation will be critical for optimizing therapeutic strategies to target DDR defects in these diseases.
Epigenetic control over the cell-intrinsic immune response antagonizes self-renewal in acute myeloid leukemia
Authors: Felipe Fumero Eloísa , Walter Carolin , Frenz Joris Maximillian , Seifert Franca , Alla Vijay , Hennig Thorben , Angenendt Linus , Hartmann Wolfgang , Wolf Sebastian , Serve Hubert , Oellerich Thomas , Lenz Georg , Müller-Tidow Carsten , Schliemann Christoph , Huber Otmar , Dugas Martin , Mann Matthias , Jayavelu Ashok Kumar , Mikesch Jan-Henrik , Arteaga Maria Francisca 
Published: March 2024

Abstract
Epigenetic modulation of the cell-intrinsic immune response holds promise as a therapeutic approach for leukemia. However, current strategies designed for transcriptional activation of endogenous transposons and subsequent interferon type-I (IFN-I) response, show limited clinical efficacy. Histone lysine methylation is an epigenetic signature in IFN-I response associated with suppression of IFN-I and IFN-stimulated genes, suggesting histone demethylation as key mechanism of reactivation. In this study, we unveil the histone demethylase PHF8 as a direct initiator and regulator of cell-intrinsic immune response in acute myeloid leukemia (AML). Site-specific phosphorylation of PHF8 orchestrates epigenetic changes that upregulate cytosolic RNA sensors, particularly the TRIM25-RIG-I-IFIT5 axis, thereby triggering the cellular IFN-I response-differentiation-apoptosis network. This signaling cascade largely counteracts differentiation block and growth of human AML cells across various disease subtypes in vitro and in vivo. Through proteome analysis of over 200 primary AML bone marrow samples, we identify a distinct PHF8/IFN-I signature in half of the patient population, without significant associations with known clinically or genetically defined AML subgroups. This profile was absent in healthy CD34+ hematopoietic progenitor cells, suggesting therapeutic applicability in a large fraction of patients with AML. Pharmacological support of PHF8 phosphorylation significantly impairs the growth in samples from patients with primary AML. These findings provide novel opportunities for harnessing the cell-intrinsic immune response in the development of immunotherapeutic strategies against AML.