bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Pengetahuan tentang Pola Asuh Balita terhadap Keikutsertaan Ibu dalam Kelas Ibu Balita di Desa Pasirtalaga Kecamatan Telagasari Kabupaten Karawang Provinsi Jawa Barat
Authors: Nuriah Sifa , Rahmadyanti Rahmadyanti 
Published: March 2024

ABSTRACT The mother under five class program is a class for mothers who have children aged 0-5 years together for discussions, health nutrition services and stimulation of growth and development guided by the facilitator using the MCH handbook. The impact that can be caused if the execution of toddler mother classes does not go well is the low use of the MCH handbook which will lead to low understanding of mothers about child health. To determine the relationship between knowledge of parenting toddlers, age, education, mother's parity on participation in toddler mothers' classes. The chi-square research design uses questionnaires to be distributed directly to the respondents. Researchers will collect data using a questionnaire. Total population of 82 respondents, using total sampling. Based on statistical tests, it shows that knowledge of Mother Toddler Parenting has a p-value of 0.000 <0.05, Age has a p-value of 0.009 <0.05, Latest education has a p-value of 0.028 <0.05, Productivity has a p-value of 0.000 < 0.05 and Parity has a p-value of 0.000 > 0.05. There is a significant relationship between knowledge of mother-to-five parenting, age, last education, productivity and parity towards class participation of mothers of toddlers aged 0-5 years in Pasirtalaga Village, Telagasari District, Kab. Karawang. Keywords: Toddler Mother Class, Knowledge of Toddler Parenting, Age, Education, Parity ABSTRAK Program kelas ibu balita adalah kelas para ibu yang mempunyai anak berusia 0-5 tahun bersama sama berdiskusi, pelayanan kesehatan gizi dan stimulasi tumbuh kembang yang di bimbing oleh fasilitator dengan menggunakan buku KIA. Dampak yang dapat ditimbulkan jika pelaksanaan kelas ibu balita tidak berjalan dengan baik yaitu rendahnya pemanfaatan buku KIA yang akan menyebabkan rendahnya pemahaman ibu terhadap kesehatan anak. Diketahuinya hubungan pengetahuan pola asuh balita, usia, pendidikan, paritas ibu terhadap ke ikutsertaan dalam kelas ibu balita. Desain penelitian chi square dengan rancangan menyebar kuesioner langsung pada responden. Peneliti akan melakukan pengumpulan data menggunakan kuesioner. Total populasi sebanyak 82 responden, menggunakan total sampling. Berdasarkan uji statistik menunjukan bahwa pengetahuan Pola Asuh Ibu Balita memiliki p-value 0,000 < 0,05, Usia memiliki p-value 0,001 < 0,05, Pendidikan terakhir memiliki p-value 0,034 < 0,05, Produktifitas memiliki p-value 0,000 < 0,05 dan Paritas memiliki p-value 0,000 > 0,05. Terdapat hubungan yang signifikan antara pengetahuan Pola Asuh Ibu Balita, Usia, Pendidikan Terakhir, Produktifitas dan Paritas tehadap Keikutsertaan Kelas Ibu Balita usia 0-5 Tahun di Desa Pasirtalaga Kecamatan Telagasari, Kab. Karawang. Kata Kunci: Kelas Ibu Balita, Pengetahuan Pola Asuh Balita, Usia, Pendidikan, Paritas
Pengaruh Motivasi, dan Disiplin terhadap Kinerja Kader Posyandu di Wilayah Desa Sumurkondang Kecamatan Klari Kabupaten Karawang
Authors: Widianingsih Gita , Yuliwati Nanik 
Published: March 2024

ABSTRACT The integrated health service program or integrated service (posyandu) is a form of integrated health services implemented in a puskesmas working area. The sustainability of this activity is highly dependent on the active participation of posyandu cadres as the main implementers. To determine the effect of motivation and discipline on the performance of posyandu cadres in the working area of Sumurkondang Village, Klari District, Karawang Regency in 2023. This research design is quantitative research. Quantitative research study in this study is observational using a cross-sectional approach that measures the independent variable and the dependent variable at the same time. The study population was all cadres in Sumurkondang Village as many as 35 people The research sample used total sampling. Bivariate analysis using the Shapiro Wilk test. The results of the chi square test can be seen that the p-value is 0.004 <0.05 and 0.000 <0.05, which means that there is a significant influence between motivation and discipline on the work performance of posyandu cadres in the Sumurkondang work area, Klari District, Karawang Regency in 2023. The conclusion is that there is a significant influence between motivation and discipline on the work performance of posyandu cadres in the Sumurkondang work area, Klari District, Karawang Regency in 2023. Keywords: Cadres, Posyandu, Discipline, Motivation, Performance ABSTRAK Program pelayanan kesehatan terpadu atau pelayanan terpadu (posyandu) adalah suatu bentuk keterpaduan pelayanan kesehatan yang dilaksanakan di suatu wilayah kerja puskesmas. Keberlangsungan kegiatan ini sangat bergantung pada partisipasi aktif dari kader posyandu sebagai pelaksana utama. Untuk mengetahui Pengaruh Motivasi dan Disiplin terhadap kinerja kader posyandu di wilayah kerja Desa Sumurkondang, Kecamatan Klari, Kabupaten Karawang Tahun 2023. Desain penelitian ini peneliitan kuantitatif. Penelitian kuantitif study pada penelitian ini bersifat observasiobal menggunakan cara pendekatan potong lintang atau Cross Sectional yang mengukur variabel independen dan variabel dependen pada waktu yang bersamaan. Populasi penelitian adalah seluruh kader di Desa Sumurkondang sebanyak 35 orang Sampel penelitian menggunakan total sampling. Analis bivariat menggunakan uji Shapiro Wilk. Hasil uji chi square dapat diketahui bahwa nilai p-value 0,004 < 0,05 dan 0,000<0,05 yang artinya ada pengaruh yang signifikan antara motivasi dan disiplin terhadap kinerja kerja kader posyandu di wilayah kerja Sumurkondang Kecamatan Klari Kabupatek Karawang Tahun 2023. Simpulan didapatkan ada pengaruh yang signifikan antara motivasi dan disiplin terhadap kinerja kerja kader posyandu di wilayah kerja Sumurkondang Kecamatan Klari Kabupatek Karawang Tahun 2023. Kata Kunci: Kader, Posyandu, Disiplin, Motivasi, Kinerja
Efektivitas Latihan Abdominal Strecting dan Senam Disminorhea terhadap Penurunan Disminorhea
Authors: Lestari Mei Puji , Anggraini Nofa 
Published: March 2024

ABSTRACT According to WHO data, it was found that the incidence of women experiencing menstrual pain was 1,769,425 people (90%) with 10% - 15% experiencing severe menstrual pain. To determine the effectiveness of abdominal stretching exercise and dysmenorrhea gymnastics on reducing primary dysmenorrhea. Using quasi-experimental with two group pretest-posttest design. The study population was young women at TPMB Joglo who had menstruated, namely 30 respondents. The research sample amounted to 30 respondents who were divided into two groups, namely 15 respondents of the abdominal streatching group and 15 respondents of dysmenorrhea gymnastics. bivariate analysis using the Wilcoxcone test. The results of the Wilcoxone Signed Test obtained a value of p=0.000 <0.05 so it can be concluded that there is an effectiveness of abdominal stretching exercises on reducing dysminorrhea. While based on the results of the Wilcoxone range list test obtained a value of p = 0.001 <0.005 so it can be concluded that there is an effectiveness of dysminorrhea gymnastics on the decline of dysminorrhea. In conclusion, abdominal stretching exercises and dysminorrhea exercises are effective for reducing menstrual pain in adolescent girls. Suggested in this study for educational institutions, for research sites, for respondents and for further researchers. Keywords: Exercise Abdominal Stretching, Menstrual Pain ABSTRAK Menurut WHO didapatkan data bahwa angka kejadian perempuan yang mengalami nyeri menstruasi sejumlah 1.769.425 jiwa (90%) dengan 10% – 15% mengalami nyeri mestruasi berat. Untuk mengetahui efektivitas abdominal stretching exercise dan senam dismenorea terhadap penurunan dismenorea primer. Menggunakan quasi eksperimental dengan rancangan two group pretest-posttest design. Populasi penelitian adalah remaja putri di TPMB Joglo yang sudah menstruasi yaitu sebanyak 30 responden. Sampel penelitian berjumlah 30 responden yang dibagi menjadi dua kelompok yaitu 15 responden kelompok abdominal streatching dan 15responden senam disiminore. analis bivariat emenggunakan uji Wilcoxcone. Hasil uji Wilcoxone Signed Test diperoleh nilai nilai p=0.000<0,05 sehingga dapat disimpulkan terdapat efektivitas Latihan abdominal stretching terhadap penurunan disminore. Sedangkan berdasarkan hasil uji wilcoxone range list di peroleh nilai p = 0,001<0,005 sehingga dapat disimpulkan terdapat efektivitas senam disminore terhadap penurunan disminore. Simpulan di dapatkan Latihan abdominal stretching dan senam disminore efektif untuk penurunan nyeri haid pada remaja putri. Disaran dalam penelitian ini untuk Institusi pendidikan, untuk tempat penelitian, untuk responden dan untuk peneliti selanjutnya. Kata Kunci: Latihan Abdominal Stretching, Disminore, Senam Disminore
Pengembangan Modul Matematika Berbasis Kearifan Lokal Bima Untuk Meningkatkan Kemampuan Numerasi Siswa
Authors: Wibowo Sarwo Edy , Ardiansyah Randi 
Published: March 2024

Pembelajaran matematika akan mudah dipahami jika dikaitkan dengan konteks daerah tempat tinggal siswa tersebut, sehingga menjadikan proses pembelajaran lebih bermakna. Namun dalam pelaksanaannya ada guru yang menggunakan bahan ajar yang kurang sesuai dengan lingkungan siswa, termasuk guru matematika di kabupaten Bima. Bahan ajar yang digunakan tidak merepresentasikan kondisi lingkungan yang ada di kabupaten Bima, ini menyebabkan siswa mengalami kesulitan dalam memahami dan mengvisualisasikan model matematika ataupun bentuk matematika yang dimaksud. Pengembangan bahan ajar berupa modul berbasis kearifan lokal Bima untuk kelas awal ini penting di adakan untuk membantu siswa di daerah memahami konsep matematika secara utuh serta maksimal dalam mencapai hasil belajar. Penelitian ini bertujuan mengembangkan dan menghasilkan produk bahan ajar berupa modul pembelajaran matematika berbasis kearifan lokal Bima pada pembelajaran matematika siswa kelas awal. Tempat penelitian yang digunakan yaitu di SDN O’o di Kecamatan Donggo Kabupaten Bima. Adapun teknik pengambilan data pada penelitian ini meliputi observasi, wawancara dan angket. Observasi dan wawancara dilakukan untuk mengumpulkan data awal sehingga bisa dijadikan acuan dalam perencanaan pengembangan modul matematika berbasis kearifan lokal Bima, adapun data hasil observasi dan wawancara ini dianalisis secara kualitatif. Adapun angket digunakan sebagai tolak ukur untuk mengetahui tingkat kevalidan produk yang divalidasi oleh tiga praktisi dan tiga ahli yaitu ahli materi, bahasa dan desain, data hasil validasi modul berupa skor yang kemudian dikelola dan dianalisis menggunakan analisis kuantitatif yang bersifat deskriptif.
Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency
Authors: Kobiela Adrian , Hewelt-Belka Weronika , Frąckowiak Joanna E. , Kordulewska Natalia , Hovhannisyan Lilit , Bogucka Aleksandra , Etherington Rachel , Piróg Artur , Dapic Irena , Gabrielsson Susanne , Brown Sara J. , Ogg Graham S. , Gutowska-Owsiak Danuta 
Published: March 2024

IntroductionExosome-enriched small extracellular vesicles (sEVs) are nanosized organelles known to participate in long distance communication between cells, including in the skin. Atopic dermatitis (AD) is a chronic inflammatory skin disease for which filaggrin (FLG) gene mutations are the strongest genetic risk factor. Filaggrin insufficiency affects multiple cellular function, but it is unclear if sEV-mediated cellular communication originating from the affected keratinocytes is also altered, and if this influences peptide and lipid antigen presentation to T cells in the skin.MethodsAvailable mRNA and protein expression datasets from filaggrin-insufficient keratinocytes (shFLG), organotypic models and AD skin were used for gene ontology analysis with FunRich tool. sEVs secreted by shFLG and control shC cells were isolated from conditioned media by differential centrifugation. Mass spectrometry was carried out for lipidomic and proteomic profiling of the cells and sEVs. T cell responses to protein, peptide, CD1a lipid antigens, as well as phospholipase A2-digested or intact sEVs were measured by ELISpot and ELISA.ResultsData analysis revealed extensive remodeling of the sEV compartment in filaggrin insufficient keratinocytes, 3D models and the AD skin. Lipidomic profiles of shFLGsEV showed a reduction in the long chain (LCFAs) and polyunsaturated fatty acids (PUFAs; permissive CD1a ligands) and increased content of the bulky headgroup sphingolipids (non-permissive ligands). This resulted in a reduction of CD1a-mediated interferon-γ T cell responses to the lipids liberated from shFLG-generated sEVs in comparison to those induced by sEVs from control cells, and an increase in interleukin 13 secretion. The altered sEV lipidome reflected a generalized alteration in the cellular lipidome in filaggrin-insufficient cells and the skin of AD patients, resulting from a downregulation of key enzymes implicated in fatty acid elongation and desaturation, i.e., enzymes of the ACSL, ELOVL and FADS family.DiscussionWe determined that sEVs constitute a source of antigens suitable for CD1a-mediated presentation to T cells. Lipids enclosed within the sEVs secreted on the background of filaggrin insufficiency contribute to allergic inflammation by reducing type 1 responses and inducing a type 2 bias from CD1a-restricted T cells, thus likely perpetuating allergic inflammation in the skin.
Prevalence and related factors of first-time suicide attempts in the past 14 days in Chinese adult patients with first-episode drug-naïve major depressive disorder
Authors: Cong Xiaoyin , Zhang Tian , Bian Rongrong , Li Yong , Liu Junjun , Zhang Xiangyang 
Published: March 2024

BackgroundThis study aimed to identify socio-demographic, physiologic, and psychologic related factors of the first-time suicide attempt (FSA) in the past 14 days in Chinese adult patients with first-episode drug-naïve (FEDN) major depressive disorder (MDD).MethodsA total of 1718 adult patients with FEDN MDD were enrolled in this cross-sectional survey. Depression, anxiety symptoms, and suicide attempts were assessed. Additionally, biological samples were collected and measured, while Logistic regression analysis was employed to explore the risk factors for FSA in the past 14 days among FEDN MDD patients.ResultsAmong suicide attempters, 12.11% (208 out of 1718) reported experiencing FSA in the past 14 days. Logistic regression analysis showed that the risk factors for FSA included more severe anxiety symptoms (OR=1.37, 95%CI: 1.28-1.48, p&lt;0.001), higher levels of total cholesterol (TC) (OR=1.42, 95%CI: 1.13-1.77, p=0.003), and elevated thyroid-stimulating hormone (TSH) (OR=1.13, 95%CI: 1.03-1.25, p=0.01). The regression model exhibited good discriminatory power for FSA with an area under the curve (AUC) of 0.82.ConclusionFEDN MDD patients with more severe anxiety and higher levels of TSH and TC are more likely to develop FSA in the past 14 days. These factors are risk factors for short-term (in the past 14 days) FSA and may serve as indicators for early intervention.
Verification of Actinomycets in Chronic Apical Periodontitis
Authors: Максимович Е.В. , Кураленя С.Ф. 
Published: March 2024

Актиномицеты являются естественными обитателями организма человека, в том числе и полости рта, однако они могут явиться причиной развития патологического процесса. Актиномикоз – это хроническое инфекционное заболевание, вызываемое актиномицетами, хроническая медленно прогрессирующая специфическая инфекция. Цель. Верифицировать актиномицеты при морфологическом исследовании грануляционной ткани у пациентов с хроническим апикальным периодонтитом. Материалы и методы. Предметом исследования являлся морфологический материал – грануляционная ткань, полученная в результате кюретажа лунки зуба, показанием к удалению которого явился хронический апикальный периодонтит. Было исследовано 28 объектов – грануляционная периапикальная ткань (из лунок удаленных зубов). Результаты и обсуждение. При исследовании макропрепаратов препараты, где были выявлены актиномицеты, представляли собой фрагменты ткани серо-коричневого, серого цвета. При исследовании микропрепаратов с окраской по Граму у 14,3% (4) пациентов были выявлены скопления актиномицетов на поверхности эпителия. Заключение. У пациентов с хроническим апикальным периодонтитом его актиномикозная этиология при морфологическом исследовании грануляционной ткани верифицирована в 14,3% наблюдений. Выявление актиномицет, представителей микробиоты полости рта, условно-патогенных микроорганизмов, при инфекционно-воспалительном процессе является маркером снижения иммунологической реактивности организма пациента, что определяет необходимость динамического наблюдения в послеоперационном периоде и назначения по показаниям антибактериальной терапии.
Actinomycetes are natural inhabitants of the human body, including the oral cavity, but they can cause the development of a pathological process. Actinomycosis is a chronic infectious disease caused by actinomycetes, a chronic, slowly progressive specific infection. The purpose. To verify actinomycetes during a morphological study of granulation tissue in patients with chronic apical periodontitis. Materials and methods. The subject of the study was morphological material - granulation tissue obtained as a result of curettage of the tooth socket, the indication for removal of which was chronic apical periodontitis. 28 objects were examined. Results and discussion. Granulation tissue with actinomycetes were detected as gray- brown, gray tissue fragments. Morphological objects in 14.3% showed accumulations of actinomycetes on the epithelium surface. Conclusion. In patients with chronic apical periodontitis, the actinomycosis etiology was verified morphologically in 14.3% of cases. Identification of actinomycetes, representatives of the microbiota of the oral cavity, conditionally pathogenic microorganisms, in inflammatory process is a marker of a decrease in the human immunological reactivity, which determines the need for dynamic monitoring in the postoperative period and the appointment of antibiotic therapy according to indications.
Riesgo laboral y su relación con las enfermedades ocupacionales en cooperativas de transporte interprovincial
Authors: Moya-Abril Janeth Anavela , Reinoso-Avecillas Marco Benito 
Published: March 2024

El objetivo de este estudio es evaluar las condiciones ergonómicas y la prevalencia de lesiones musculoesqueléticas en los trabajadores de la Cooperativa de Transporte Interprovincial Caluma, localizada en la provincia de Bolívar. La metodología utilizada fue descriptiva enfocada en la observación y medición de variables ergonómicas, así como en la detección de lesiones. Los resultados muestran una alta prevalencia de incomodidad física, fatiga visual por la iluminación en las carreteras y diversos dolores musculoesqueléticos, como dolor de codo, cuello, hombro, espalda alta, espalda baja, muñeca, caderas/piernas, rodillas y tobillos/pies, entre los trabajadores. Estos hallazgos resaltan la necesidad de mejorar las condiciones ergonómicas y de seguridad laboral para prevenir lesiones y promover el bienestar de los empleados.
Chondroitin Sulfate for Osteoarthritis – Is There a Risk for Cancer: an Analysis of Osteoarthritis Initiative Data
Authors: Lambova Sevdalina Nikolova , Shirinsky Valery , Shirinsky Ivan 
Published: March 2024

The aim of this study was to evaluate the association between chondroitin sulfate (CS) use and incidence of self-reported cancer during 6-year follow up in the publicly available Osteoarthritis Initiative (OAI) cohort participants.
Materials and Methods: The current study included analysis of 6-year longitudinal data obtained from the OAI progression (n= 1390) and incidence (n = 3284) subcohorts that are publicly available at https://nda.nih.gov/oai/. The inclusion criteria for OAI were the following: age between 45 and 79 years for both subcohorts, symptomatic tibiofemoral knee osteoarthritis (OA) for the progression subcohort, and the presence of established or putative risk factors for incident knee OA for the incidence subcohort. The OAI participants were recruited and enrolled between February 2004 and May 2006 at four recruitment centres in the United States. This study received ethical approval from each recruitment centre. All participants provided written informed consent. To reduce the risk of bias, only participants who did not take CS at baseline were included in the analysis (a “new-user” design).
Results: 570 (18%) new users of CS and 2597 (82%) CS non-users were compared. In the CS user group, 294 (51.6%) participants received CS for more than one year, 291 (33.5%) for more than 2 years, 123 (21.6%) for more than 3 years, and 60 (10.5%) for more than 4 years. None of the participants received CS for more than 5 years. CS users and non-users were of the same age, had similar male/female ratio, and similar body mass index. In the non-user group, there were more African-American participants and there were more current smokers. 160 (6.2%) and 37 (6.5%) cases of incident self-reported cancer in the non-users and user groups were identified. There was no association between the use of CS and incident self-reported cancer in the non-adjusted analyses. The adjustments for age, race and smoking status did not change the results.
Conclusion: The results of the current study did not show an association between CS use and self-reported cancers. Considering the complex function of CS in the development and progression of malignant tumors, there is a need for further epidemiological studies evaluating CS effects on specific types of cancers and in different genetic backgrounds.
Copper ion sorption ability of Alternaria alternata (Fr.) Keissl. and Fusarium oxysporum Schltdl. micromycetes
Authors: Volkova V. D. , Fedoseeva E. V. , Terekhova V. A. 
Published: March 2024

Our analysis of metabolic and ecological features of fungi indicates a high bioremediation potential of fungal mycelium. The relevance of the problems solved in this work is conditioned by insufficiently studied mechanisms and conditions of micromycetal activity on heavy metal detoxication. The effect of copper on the development of two micromycete species, namely, melanised Alternaria alternata (Fr.) Keissl., 1912 and hyaline Fusarium oxysporum Schltdl., 1824 cultivated on Czapek agar (with 2 or 3% sucrose) was compared; the ability of mycelium to sorb copper cations when grown in a liquid culture with 0, 0.05, 0.1, 0.25, and 0.5 mg Cu2+ / L was evaluated. F. oxysporum had noticeable advantages in terms of growth rate, tolerance, conidia production on medium with Cu2+. The effective concentration of copper (EC50), indicating the resistance of the fungus, increased for F. oxysporum by 1.5 times with increasing sucrose content in the medium. The melanised culture of A. alternata was superior to F. oxysporum in terms of sorption capacity. The percentage of Cu2+ extraction by fungal mycelium from the medium reached 40% in the case of F. oxysporum and twice as much in the case of A. alternata . The vast majority of copper was sorbed by the cell walls of hyphae and washed away by water. A small amount (a maximum of 0.16 µg Cu2+ /g dry mycelium of A. alternate ) penetrated inside the mycelial cells. F. oxysporum, which had no intracellular protective melanins, accumulated Cu2+ (2 to 14 times) less. The results show that the mechanisms of resistance to Cu2+ and sorption are different in the studied species: in Fusarium they are determined mainly by the barrier functions of hyphae cell walls, while in Alternaria melanin plays a significant role in protection against Cu toxic action.