bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘I don’t want to play with you anymore’: dynamic partner judgements in moody reinforcement learners playing the prisoner’s dilemma
Authors: Feehan Grace , Fatima Shaheen 
Published: March 2024

Abstract
Emerging reinforcement learning algorithms that utilize human traits as part of their conceptual architecture have been demonstrated to encourage cooperation in social dilemmas when compared to their unaltered origins. In particular, the addition of a mood mechanism facilitates more cooperative behaviour in multi-agent iterated prisoner dilemma (IPD) games, for both static and dynamic network contexts. Mood-altered agents also exhibit humanlike behavioural trends when environmental aspects of the dilemma are altered, such as the structure of the payoff matrix used. It is possible that other environmental effects from both human and agent-based research will interact with moody structures in previously unstudied ways. As the literature on these interactions is currently small, we seek to expand on previous research by introducing two more environmental dimensions; voluntary interaction in dynamic networks, and stability of interaction through varied network restructuring. From an initial Erdos–Renyi random network, we manipulate the structure of a network IPD according to existing methodology in human-based research, to investigate possible replication of their findings. We also facilitated strategic selection of opponents through the introduction of two partner evaluation mechanisms and tested two selection thresholds for each. We found that even minimally strategic play termination in dynamic networks is enough to enhance cooperation above a static level, though the thresholds for these strategic decisions are critical to desired outcomes. More forgiving thresholds lead to better maintenance of cooperation between kinder strategies than stricter ones, despite overall cooperation levels being relatively low. Additionally, moody reinforcement learning combined with certain play termination decision strategies can mimic trends in human cooperation affected by structural changes to the IPD played on dynamic networks—as can kind and simplistic strategies such as Tit-For-Tat. Implications of this in comparison with human data is discussed, and suggestions for diversification of further testing are made.
Worker takeovers: a comparative analysis of employee buyouts, other worker-managed firms, and conventional firms in Uruguay
Authors: Dean Andrés 
Published: March 2024

Abstract
The economic crisis experienced by many developed countries over the past decade saw the emergence of the phenomenon of so-called recovered firms (RFs), or employee buyouts of failed capitalist firms (CFs). While it is obvious that one of the objectives sought by these workers is to keep their jobs, the subsequent performance of these firms is unclear. Are RFs more likely to fail than other worker managed firms (WMFs) or than CFs? Do RF workers get higher incomes than their peers in other WMFs or in CFs? This analysis is based on a linked employer–employee panel data set from Uruguayan social security administrative records. The main findings are that RFs survive longer than other WMFs or than CFs. However, RF workers receive incomes lower than those of their peers at other WMFs or at CFs. This income differential is explained partly by a brain drain process and specific human capital losses.
‘Route Causes’ and Consequences of Irregular (Re-)Migration: Vulnerability as an Indicator of Future Risk in Refugee Law
Authors: Grundler Maja 
Published: March 2024

AbstractStates’ bordering practices force individuals to undertake dangerous migratory journeys and put them at risk of severe human rights violations. Yet, irregular arrivals who are found not to be at risk of serious harm in their countries of origin are perceived as voluntary migrants and are therefore assumed not to be in need of protection. This article employs the concept of vulnerability to challenge the idea that both the initial and subsequent dangerous migratory journeys are undertaken voluntarily. Based on an analysis of trafficking-based asylum claims from the UK and Germany, the article shows that both re-trafficking and irregular re-migration result from vulnerabilities which converge to preclude reintegration in the country of origin and access to livelihood options. While some of these vulnerabilities are likely to be present at the time of the initial dangerous journey already, the article pays particular attention to ‘consequential vulnerabilities’ brought about by previous migration experiences. It then introduces the concept of ‘route causes’ of irregular re-migration to describe factors which heighten the risk of re-migrating irregularly and therefore establish a risk on return related to harm experienced during irregular migration, rather than in the country of origin. Thus, the article shows that the vulnerability concept informs the future risk analysis in refugee law and argues that, just like a risk of re-trafficking, a risk of irregular re-migration could form the basis of an asylum claim.
On the Basis of Migratory Vulnerability: Augmenting Article 14 of the European Convention on Human Rights in the Context of Migration
Authors: Baumgärtel Moritz , Ganty Sarah 
Published: March 2024

AbstractThe fact that migration cases seldom raise any questions under Article 14 of the European Convention on Human Rights (ECHR) is neither inevitable nor justified. This article reaffirms the equality provision as a useful and indeed necessary mechanism for the European Court of Human Rights to deal with such applications. More concretely, we build on our previous work, which identified a legal tool suitable for achieving this reorientation in judicial practice: the principle that we call ‘migratory vulnerability’, once recalibrated away from a group-based approach to a notion of vulnerability as situational and socially induced. In this article, we explain how the principle of migratory vulnerability, even if it does not represent an inherently suspect ground of differentiation, enables us to identify instances of discrimination defined as a measurable disadvantage that is disproportionate or arbitrary and cannot, therefore, be reasonably justified on the basis of the Convention. This presupposes a move away from nationality as a privileged ground in migration-related cases and from the ‘comparator’ test to determine Article 14 ECHR violations, to also encompass situational experiences. We end with two examples that show that this reconceptualization is both workable in practice and of added value, enabling the Court to find violations that presently go undetected.
Telling Phaedrus' fables to children. A cruel language? A linguistic analysis in Italian books
Authors: Regagliolo Alberto 
Published: March 2024

Abstract
Teaching classical culture to children can be done through literature and Phaedrus' fables. There are several books on the market that can be used to introduce Phaedrus' fables to children. However, in order to be suitable, the books should follow some requirements of appropriateness related to the use of the language and the values to be shared, among others. In this study, through the analysis of 12 Italian books on Phaedrus' fables for children, it will be analysed how the death of an animal is described through the use of verbs and structures. The research aims at making observations on how some books for children represent cruelty and the adoption of certain linguistic structures. The analysis shows, in the first place, that the authors never eliminate the death/killing of the animal; secondly, the verbs and expressions used are varied but, in most cases, cruel, and direct without making the death softer.
Short-Scale Construction Using Meta-Analytic Ant Colony Optimization
Authors: Schroeders Ulrich , Morgenstern Maximilian , Jankowsky Kristin , Gnambs Timo 
Published: March 2024

Abstract: The Need for Cognition Scale (NCS) is a self-report scale measuring individual differences in the tendency to engage in and enjoy thinking. The shortened version with 18 items (NCS-18; Cacioppo et al., 1984 ) has widely been administered in research on persuasion, critical thinking, and educational achievement. Whereas most studies advocated for essential uni-dimensionality, the question remains which psychometric model yields the best representation of the NCS-18. In the present study, we compared six competing measurement models for the NCS-18 with meta-analytic structural equation models using summary data of 87 samples ( N = 90,215). Results demonstrated that the negatively worded items introduced considerable measurement bias that was best accounted for with an acquiescence model. In a further analytical step, we showcased how the pooled correlation matrix can be used to compile short versions of the NCS-18 via Ant Colony Optimization. We examined model fit and reliability of short scales with varying item numbers (between 4 and 15) and a balanced ratio of positively and negatively worded items. We discuss the potentials and limits of the newly proposed method.
Ocean Heat Content Increase of the Maritime Continent Since the 1990s
Authors: Jin Yuchun , Li Yuanlong , Cheng Lijing , Duan Jing , Li Rui , Wang Fan 
Published: March 2024

AbstractThe Maritime Continent (MC), a critical region for inter‐basin climate interaction, harbors the world's highest marine biodiversity. Ocean warming in the MC, although with notable impacts on regional climate and marine ecosystems, remains poorly constrained by observations. By applying a volume‐correction algorithm to existing gridded observational data sets, this study provides an estimate for the ocean heat content (OHC) change of the MC. The results suggest a substantial OHC increase of 2.65 ± 0.46 Zettajoules during 1990–2015 (1.08 ± 0.17 W m−2) and limited changes before and after. This increase primarily arose from the enhanced Pacific Walker circulation, which drove a convergence of upper‐layer warm water toward the MC. A potential heat storage “hotspot” with enhanced warming below 500 m emerges within the Sulu Sea, which is supported by analysis of profile data collected in boreal winter but not in other seasons.
A Model for Air Entrainment Rates in Oceanic Whitecaps
Authors: Callaghan Adrian H. 
Published: March 2024

AbstractAir‐entraining whitecaps provide an important source of bubbles over the global oceans, yet the rate at which the associated air is entrained is not well known. This lack of understanding limits the ability to accurately parameterize bubble‐mediated gas exchange and sea spray aerosol flux. In this paper I present a model to predict the total volume of air entrained by individual whitecaps and extend it to estimate the rate at which air is entrained per unit sea surface area. The model agrees well with existing models and measurements and can be forced by the rate at which energy is dissipated by the wavefield which can be routinely provided by spectral wave models. I then use the model to present the first distributions of the estimated total volume of air entrained by individual whitecaps, as well as their rate of air entrainment and air degassing.
Sex dimorphism controls dysbindin-related cognitive dysfunctions in mice and humans with the contribution of COMT
Authors: Geraci Federica , Passiatore Roberta , Penzel Nora , Laudani Samuele , Bertolino Alessandro , Blasi Giuseppe , Graziano Adriana C. E. , Kikidis Gianluca C. , Mazza Ciro , Parihar Madhur , Rampino Antonio , Sportelli Leonardo , Trevisan Nicolò , Drago Filippo , Papaleo Francesco , Sambataro Fabio , Pergola Giulio , Leggio Gian Marco 
Published: March 2024

AbstractCognitive dysfunctions are core-enduring symptoms of schizophrenia, with important sex-related differences. Genetic variants of the DTBPN1 gene associated with reduced dysbindin-1 protein (Dys) expression negatively impact cognitive functions in schizophrenia through a functional epistatic interaction with Catechol-O-methyltransferase (COMT). Dys is involved in the trafficking of dopaminergic receptors, crucial for prefrontal cortex (PFC) signaling regulation. Moreover, dopamine signaling is modulated by estrogens via inhibition of COMT expression. We hypothesized a sex dimorphism in Dys-related cognitive functions dependent on COMT and estrogen levels. Our multidisciplinary approach combined behavioral-molecular findings on genetically modified mice, human postmortem Dys expression data, and in vivo fMRI during a working memory task performance. We found cognitive impairments in male mice related to genetic variants characterized by reduced Dys protein expression (pBonferroni = 0.0001), as well as in male humans through a COMT/Dys functional epistatic interaction involving PFC brain activity during working memory (t(23) = −3.21; pFDR = 0.004). Dorsolateral PFC activity was associated with lower working memory performance in males only (p = 0.04). Also, male humans showed decreased Dys expression in dorsolateral PFC during adulthood (pFDR = 0.05). Female Dys mice showed preserved cognitive performances with deficits only with a lack of estrogen tested in an ovariectomy model (pBonferroni = 0.0001), suggesting that genetic variants reducing Dys protein expression could probably become functional in females when the protective effect of estrogens is attenuated, i.e., during menopause. Overall, our results show the differential impact of functional variants of the DTBPN1 gene interacting with COMT on cognitive functions across sexes in mice and humans, underlying the importance of considering sex as a target for patient stratification and precision medicine in schizophrenia.
Chronometric TMS-fMRI of personalized left dorsolateral prefrontal target reveals state-dependency of subgenual anterior cingulate cortex effects
Authors: Grosshagauer Sarah , Woletz Michael , Vasileiadi Maria , Linhardt David , Nohava Lena , Schuler Anna-Lisa , Windischberger Christian , Williams Nolan , Tik Martin 
Published: March 2024

AbstractTranscranial magnetic stimulation (TMS) applied to a left dorsolateral prefrontal cortex (DLPFC) area with a specific connectivity profile to the subgenual anterior cingulate cortex (sgACC) has emerged as a highly effective non-invasive treatment option for depression. However, antidepressant outcomes demonstrate significant variability among therapy plans and individuals. One overlooked contributing factor is the individual brain state at the time of treatment. In this study we used interleaved TMS-fMRI to investigate the influence of brain state on acute TMS effects, both locally and remotely. TMS was performed during rest and during different phases of cognitive task processing. Twenty healthy participants were included in this study. In the first session, imaging data for TMS targeting were acquired, allowing for identification of individualized targets in the left DLPFC based on highest anti-correlation with the sgACC. The second session involved chronometric interleaved TMS-fMRI measurements, with 10 Hz triplets of TMS administered during rest and at distinct timings during an N-back task. Consistent with prior findings, interleaved TMS-fMRI revealed significant BOLD activation changes in the targeted network. The precise timing of TMS relative to the cognitive states during the task demonstrated distinct BOLD response in clinically relevant brain regions, including the sgACC. Employing a standardized timing approach for TMS using a task revealed more consistent modulation of the sgACC at the group level compared to stimulation during rest. In conclusion, our findings strongly suggest that acute local and remote effects of TMS are influenced by brain state during stimulation. This study establishes a basis for considering brain state as a significant factor in designing treatment protocols, possibly improving TMS treatment outcomes.
Alterations in subcortical magnetic susceptibility and disease-specific relationship with brain volume in major depressive disorder and schizophrenia
Authors: Shibukawa Shuhei , Kan Hirohito , Honda Shiori , Wada Masataka , Tarumi Ryosuke , Tsugawa Sakiko , Tobari Yui , Maikusa Norihide , Mimura Masaru , Uchida Hiroyuki , Nakamura Yuko , Nakajima Shinichiro , Noda Yoshihiro , Koike Shinsuke 
Published: March 2024

AbstractQuantitative susceptibility mapping is a magnetic resonance imaging technique that measures brain tissues’ magnetic susceptibility, including iron deposition and myelination. This study examines the relationship between subcortical volume and magnetic susceptibility and determines specific differences in these measures among patients with major depressive disorder (MDD), patients with schizophrenia, and healthy controls (HCs). This was a cross-sectional study. Sex- and age- matched patients with MDD (n = 49), patients with schizophrenia (n = 24), and HCs (n = 50) were included. Magnetic resonance imaging was conducted using quantitative susceptibility mapping and T1-weighted imaging to measure subcortical susceptibility and volume. The acquired brain measurements were compared among groups using analyses of variance and post hoc comparisons. Finally, a general linear model examined the susceptibility–volume relationship. Significant group-level differences were found in the magnetic susceptibility of the nucleus accumbens and amygdala (p = 0.045). Post-hoc analyses indicated that the magnetic susceptibility of the nucleus accumbens and amygdala for the MDD group was significantly higher than that for the HC group (p = 0.0054, p = 0.0065, respectively). However, no significant differences in subcortical volume were found between the groups. The general linear model indicated a significant interaction between group and volume for the nucleus accumbens in MDD group but not schizophrenia or HC groups. This study showed susceptibility alterations in the nucleus accumbens and amygdala in MDD patients. A significant relationship was observed between subcortical susceptibility and volume in the MDD group’s nucleus accumbens, which indicated abnormalities in myelination and the dopaminergic system related to iron deposition.
Molecular mechanisms involved in alcohol craving, IRF3, and endoplasmic reticulum stress: a multi-omics study
Authors: Ho Ming-Fen , Zhang Cheng , Moon Irene , Tuncturk Mustafa , Coombes Brandon J. , Biernacka Joanna , Skime Michelle , Oesterle Tyler S. , Karpyak Victor M. , Li Hu , Weinshilboum Richard 
Published: March 2024

AbstractAlcohol use disorder (AUD) is the most prevalent substance use disorder worldwide. Acamprosate and naltrexone are anti-craving drugs used in AUD pharmacotherapy. However, molecular mechanisms underlying their anti-craving effect remain unclear. This study utilized a patient-derived induced pluripotent stem cell (iPSC)-based model system and anti-craving drugs that are used to treat AUD as “molecular probes” to identify possible mechanisms associated with alcohol craving. We examined the pathophysiology of craving and anti-craving drugs by performing functional genomics studies using iPSC-derived astrocytes and next-generation sequencing. Specifically, RNA sequencing performed using peripheral blood mononuclear cells from AUD patients with extreme values for alcohol craving intensity prior to treatment showed that inflammation-related pathways were highly associated with alcohol cravings. We then performed a genome-wide assessment of chromatin accessibility and gene expression profiles of induced iPSC-derived astrocytes in response to ethanol or anti-craving drugs. Those experiments identified drug-dependent epigenomic signatures, with IRF3 as the most significantly enriched motif in chromatin accessible regions. Furthermore, the activation of IRF3 was associated with ethanol-induced endoplasmic reticulum (ER) stress which could be attenuated by anti-craving drugs, suggesting that ER stress attenuation might be a target for anti-craving agents. In conclusion, we found that craving intensity was associated with alcohol consumption and treatment outcomes. Our functional genomic studies suggest possible relationships among craving, ER stress, IRF3 and the actions of anti-craving drugs.
Identifying plasma metabolic characteristics of major depressive disorder, bipolar disorder, and schizophrenia in adolescents
Authors: Yin Bangmin , Cai Yuping , Teng Teng , Wang Xiaolin , Liu Xueer , Li Xuemei , Wang Jie , Wu Hongyan , He Yuqian , Ren Fandong , Kou Tianzhang , Zhu Zheng-Jiang , Zhou Xinyu 
Published: March 2024

AbstractMajor depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are classified as major mental disorders and together account for the second-highest global disease burden, and half of these patients experience symptom onset in adolescence. Several studies have reported both similar and unique features regarding the risk factors and clinical symptoms of these three disorders. However, it is still unclear whether these disorders have similar or unique metabolic characteristics in adolescents. We conducted a metabolomics analysis of plasma samples from adolescent healthy controls (HCs) and patients with MDD, BD, and SCZ. We identified differentially expressed metabolites between patients and HCs. Based on the differentially expressed metabolites, correlation analysis, metabolic pathway analysis, and potential diagnostic biomarker identification were conducted for disorders and HCs. Our results showed significant changes in plasma metabolism between patients with these mental disorders and HCs; the most distinct changes were observed in SCZ patients. Moreover, the metabolic differences in BD patients shared features with those in both MDD and SCZ, although the BD metabolic profile was closer to that of MDD than to SCZ. Additionally, we identified the metabolites responsible for the similar and unique metabolic characteristics in multiple metabolic pathways. The similar significant differences among the three disorders were found in fatty acid, steroid-hormone, purine, nicotinate, glutamate, tryptophan, arginine, and proline metabolism. Interestingly, we found unique characteristics of significantly altered glycolysis, glycerophospholipid, and sphingolipid metabolism in SCZ; lysine, cysteine, and methionine metabolism in MDD and BD; and phenylalanine, tyrosine, and aspartate metabolism in SCZ and BD. Finally, we identified five panels of potential diagnostic biomarkers for MDD-HC, BD-HC, SCZ-HC, MDD-SCZ, and BD-SCZ comparisons. Our findings suggest that metabolic characteristics in plasma vary across psychiatric disorders and that critical metabolites provide new clues regarding molecular mechanisms in these three psychiatric disorders.