bluuebunny/crossref_metadata_2025_split huggingface dataset:
Substance P in the localization of a carcinoid tumor
Authors: Strodel William E. , Vinik Aaron I. , Jaffe Bernard M. , Eckhauser Frederic E. , Thompson Norman W. 
Published: February 2007

AbstractA 55‐year‐old woman with an ovarian carcinoid presented with intermittent facial and cervical flushing for 10 years, watery diarrhea for 4 years, and abdominal pain without hepatomegaly. Markedly elevated systemic venous and arterial serotonin levels (830 ng/ml; nl = 50‐200 ng/ml) were found. The highest serotonin levels were observed in the superior venal caval system, but serotonin as a marker for tumor localization was inaccurate and led to an unproductive neck exploration. The histological pattern of this tumor contained purely insular elements. No hepatic or nodal metastases were identified and the lesion was unilateral. Substance P levels were elevated in the venous drainage of the left ovary and in retrospect correctly localized the ovarian tumor. This peptide may prove to be another carcinoid tumor marker in addition to serotonin and 5‐hydroxyindolacetic acid. Substance P may also be an important mediator of symptoms in patients with carcinoid syndrome.
The influence of cryosurgery and electrocoagulation upon metastatic spread
Authors: Zonnevylle J. A. , Zwaveling A. 
Published: February 2007

AbstractAn experiment was performed to investigate the hypothesis that cryosurgery or electrocoagulation of a tumor can have an inhibitory effect upon the metastatic process. Prior investigation had shown that both electrocoagulation and cryosurgery were as effective in causing a local cure of tumor as local excision. An intravenous injection of tumor cells was given a week after local treatment of 10‐day‐old subcutaneous tumors had been administered, and 2 weeks later the number of lung metastases was counted.No extra beneficial effect of cryosurgery or electrocoagulation upon the metastatic process could be demonstrated, neither with the antigenic tumor system used nor with two nonantigenic systems.
Malignant neoplasm of mixed mesenchymal and neuroepithelial origin (ectomesenchymoma) of thigh
Authors: Shuangshoti Samruay , Kasantikul Vira , Suwangool Pongsepeera , Chittmittrapap Soottiporn 
Published: February 2007

AbstractA 49‐year‐old man had a malignant soft tissue tumor of the right thigh with metastasis to the femoral region and lower quadrant of the anterior abdominal wall on the right side and the left supraclavicular lymph nodes. The neoplasm showed features of chondrosarcoma and primitive neuroectodermal tumor (combined neuroblastoma, ependymoma, astrocytoma. and oligodendroglioma). The gliomatous part of the mixed tumor was confirmed by identification of the glial fibrillary acidic protein (GFAP). The diverse cellular population suggests a tumor origin from the ectomesenchymal remnant of the neural crest. The mesenchymal component of the neural crest would differentiate into the chondrosarcoma and the neuroectodermal component into the primitive neuroectodermal neoplasm. These various neoplastic elements, then, would form a neoplasm of mixed mesenchymal and neuroepithelial origin or an ectomesenchymoma.
Effect of impaired renal function on tamoxifen
Authors: Sutherland Carl M. , Sternson Larry A. , Muchmore James H. , Ball John E. , Cerise Elmo J. 
Published: February 2007

AbstractThere is no information available in the literature on the blood levels of tamoxifen in patients with decreased renal function. As serious side effects of tamoxifen administered at high doses have been reported, a patient with decreased renal function and metastatic breast cancer was studied to determine the blood levels of tamoxifen while under therapy. Since no abnormally elevated levels of tamoxifen were found in this patient during the month of therapy, results of this study indicate that tamoxifen can be administered to patients with some degree of renal impairment without the risk of giving rise to abnormally elevated blood levels.
Avidin‐biotin technique is more sensitive than lectin assay for detecting the thomsen friedenreich antigen (T‐antigen) in transitional cell carcinoma of the bladder
Authors: McAlpine Robert G. , Javadpour Nasser , Vafier James A. , Worsham G. F. , O'connell Kevin J. 
Published: February 2007

AbstractAvidin biotin technique and lectin assay has been compared in a doubleblind study for detection of the T‐antigen in transitional carcinoma of the bladder. Utilizing the tumor registry from the U.S. Naval Hospital in Bethesda, Maryland, patients with transitional cell carcinoma of the bladder were identified. Thirty‐three patients were selected with a total of 43 specimens. Tissues from 26 patients with a total of 43 specimens that showed no lesions and had no known history of genitourinary diseases were used as controls. These tissues were studied for the presence of T‐antigen utilizing avidin biotin or lectin techniques. T‐antigen was detected in 60% of the specimens with lectin technique, while 95% was detected with avidin biotin methods. The T‐antigen was not detected by either method even after the treatment with neuraminidase in six patients. These patients had high grade and high stage tumors. This study demonstrated that normal urothelium has concealed T‐antigen that can be exposed by treating the tissue with neuraminidase. However, the T‐antigen is unconcealed in low grade tumor but disappears in high grade invasive tumor. Avidin biotin technique appears to be a more sensitive method for detecting the presence or absence of the T‐antigen.
Colonization of nonmelanocytic cutaneous lesions by dendritic melanocytic cells: A simulant of acral‐lentiginous (Palmar‐plantar‐subungual‐mucosal) melanoma
Authors: Lambert Muriel W. , Clark Lambert W. , Schwartz Robert A. , Mesa Myra L. , Brodkin Roger H. , Abbey Albert H. , Potter Gene K. , Little R. Walter P. 
Published: February 2007

AbstractFour cases of colonization of nonmelanocytic lesions by dendritic melanocytic cells are reported, one in a verruca vulgaris of the lip, one in a squamous cell carcinoma in situ of mucous membrane overlying a tonsil, one in a lesion of lichen simplex chronicus with a nevocellular nevus of the external ear, and one in a dermatofibrosarcoma protuberans (Bednar tumor). This is an important biological process of melanocytes that must not be confused with the acral‐lentiginous (palmar‐plantar‐subungual‐mu‐cosal (P‐S‐M) melanoma. It is probably much more common than the paucity of published reports would indicate.
Primary intracranial germinoma with massive ventriculoperitoneal shunt metastases
Authors: Talamo Thomas S. , Mendelow Harvey 
Published: February 2007

AbstractVentriculoperitoneal shunt metastases from primary intracranial germinomas are extremely rare. To date, only three case reports of this phenomenon have appeared in the literature. We present the case of a 25‐year‐old black male who developed ventriculoperitoneal shunt metastases 10 months following diagnosis of an intracranial germinoma. Radiotherapy destroyed most of the intracranial tumor, but abdominal metastases became progressive and were not treated with radiotherapy. The role of radiotherapy in the treatment of ventriculoperitoneal shunt metastases is examined and previous cases in the literature are reviewed.
Chondrosarcoma of the head and neck—the value of computed tomography
Authors: Hertzanu Y. , Mendelsohn D. B. , Davidge‐Pitts K. , Cohen M. 
Published: February 2007

AbstractChondrosarcomas of the head and neck represent a small percentage and differ in their treatment and prognosis compared with chondrosarcomas elsewhere. Four different cases of chondrosarcoma are presented. One arose intracranially, two in the jaws, one of which followed irradiation for a retinoblastoma, and the last represents chondrosarcomatous transformation in cervical spine Paget disease which is exceptionally rare. Computer tomography (CT) plays an important role in delineating the extent of the tumor with visualization of bony destruction, associated soft‐tissue mass, and calcification, information which is extremely important for surgical and therapeutic planning. CT can be vital in suggesting the best possible site for biopsy which is particularly important in this group of neoplasms where the histological diagnosis may be difficult.
Mitomycin C extravasation ulcers
Authors: Khanna A. K. , Khanna Anuradha , Asthana A. K. , Misra M. K. 
Published: February 2007

AbstractIn a four‐year period, eight patients with mitomycin C extravasation ulcers were encountered. Mitomycin C extravasation produces a painful indolent ulcer that does not have any tendency to heal. If extravasation of the drug is recognized, infusion should be stopped immediately, and the site of infusion should be changed. The ulcers should be excised, and primary closure is recommended; if it is not possible then the defect is covered by a partial thickness skin graft.
An apparent danazol‐induced primary hepatocellular carcinoma: Case report
Authors: Buamah Paul K. 
Published: February 2007

AbstractThis paper presents an apparent case of danazol‐induced primary hepatocellular carcinoma in a 49‐year‐old patient, following two years of continuous therapy with this inhibitor of pituitary gonadotrophin. Discontinuation of the drug failed to cause regression of the tumour.
The significance of metastasis to the bones and soft tissues of the hand
Authors: Morris Don M. , House Homer C. 
Published: February 2007

AbstractWe have treated six patients with cancer metastatic to the hand. All patients died within 6 months after the appearance of hand metastasis. We polled the combined membership of the American Association for Surgery of the Hand and the American Society for Surgery of the Hand to determine their experience with this problem. We also reviewed the pertinent literature concerning this subject. The information obtained from the literature and the poll confirmed our experience. We have managed these patients by amputation, feeling that reconstructive procedures were not indicated if the time necessary to rehabilitate the patient after reconstruction exceeds the patient's life expectancy.
Surgical treatment of concurrent cancer of the esophagus and stomach
Authors: Okudaira Yasuyuki , Sugimachi Keizo , Ueo Hiroaki , Kai Hidenobu , Kuwano Hiroyuki , Inokuchi Kiyoshi 
Published: February 2007

AbstractOut of a total of 250 resections for carcinoma of the esophagus done in our department between 1965 and 1983, there were 11 patients with a concurrent esophageal cancer, nine being gastric cancer and seven of them early gastric cancer. In these nine, four underwent resection of the esophagus and lesser curvature of the stomach with gastric tube reconstruction. Two of the four patients are alive 10 and 3 yr postoperatively. We hold the view that detailed preoperative gastric examination is most important to plan the surgical repair and that the small gastric tube may serve as a substitute by resecting the lesser curvature of the stomach in cases of early proximal gastric cancer.
Hemangiosarcoma complicating paget's disease of the bone
Authors: Chen KARL T. K. 
Published: February 2007

AbstractAn 87‐year‐old man with Paget's disease of the left humerus was found to have a Paget's sarcoma upon pathologic examination of the left upper limb, which was disarticulated for severe pain and recurrent fractures. The histologic type of this tumor, a hemangiosarcoma, was unique among Paget's sarcomas.
Cancer of the head of the pancreas: An institutional review with emphasis on surgical therapy
Authors: Rosenberg Joel M. , Welch John P. , Macaulay William P. 
Published: February 2007

AbstractA clinical review of 461 patients with adenocarcinoma of the pancreas is presented. Seventy‐nine percent of the group underwent laparotomy, including laparotomy and biopsy (n = 134), bypass procedures (n = 207), and radical resection (n = 24). The operative mortality following chole‐cystoenterostomy or choledochoenterostomy was similar but survival was greater following the latter procedure. Thirteen percent having biliary bypass alone needed later gastric bypass. Radical resection is recommended under favorable conditions (6.6% in this series). The five‐year survival in this group was 12.5% and the operative mortality was 9% over the last 10 years.
Tissue CEA detection by immunoperoxidase (PAP) test in colorectal polyps: Correlations with the degree of dysplasia
Authors: Amanti C. , Midiri C. , Benedetti M. , Campisi C. , Di Tondo U. , Castagna C. , Peronace L. , Santeusanio G. , Dl Paola M. 
Published: February 2007

AbstractWe study the presence of Carcinoembryonic antigen (CEA) on 39 colorectal polyps by the immunoperoxidase technique. The histological examination demonstrated 15 tubular adenomas, one villous adenoma, two tubulo‐villous adenomas, six tubular adenomas with slight dysplasia, one tubular adenoma with moderate dysplasia, four tubular adenomas with severe dysplasia, three tubulo‐villous adenomas with severe dysplasia, five tubular adenomas with neoplastic degeneration, and two tubulo‐villous adenomas with neoplastic degeneration. Twenty‐eight of thirty‐nine polyps (71.79%) showed a positive staining reaction for CEA. Regarding the intensity of the reaction (classified as absent or negative [ ‐], slightly positive [ + ], and markedly positive [++]), 11/39 polyps presented a negative reaction (28.21%), 19/39 (48.71%) presented a slight reaction, and 10/39 polyps (25.64%) presented a marked reaction.Results demonstrated a higher intensity of the staining reaction in severely displastic polyps and in neoplastic degeneration. In conclusion, it is possible that the presence of CEA can be useful to show an initial cellular restlessness of certain polyps.
Adjuvant chemotherapy of gastric carcinoma: A pilot study of oral administration of injectable 5‐fluorouracil
Authors: Wu Yong‐Fang 
Published: February 2007

AbstractDuring the past three years we have entered 54 patients with gastric adenocarcinoma into a clinical trial of oral administration of injectable 5‐fluorouracil (5‐Fu). Of the 20 unresectable advanced cases, the median survival was 6.2 months, and for 34 resectable ones, median survival was 22 months. These results were comparable to those reported in the literature. It is also safe, easy to administer, well tolerated, and does not have any apparent side effects. The author discovered for the first time that oral administration of 5‐Fu could improve the liver function as manifested by a marked decrease of serum GPT level in advanced gastric cancer.
Human renal carcinoma: Characterization of five new cell lines
Authors: Barton Grossman H. , Wedemeyer Gary , Ren Liqin 
Published: February 2007

AbstractFive human renal carcinoma cell lines have been established in long‐term tissue culture. Two of the cell lines, UM‐RC‐2 and UM‐RC‐3, produced clear cell tumors in athymic nude mice. The cell lines have been characterized by staining with oil red O, doubling time in vitro, and number of chromosomes. Although protein A assay reactivity of autologous combinations of patient's sera and tumor cells were seen with all five cell lines, similar binding was also found with autologous normal kidney cultures. However, the immune adherence assay demonstrated low titer autologous reactivity with two renal carcinoma cell lines but not with the corresponding normal kidney cultures. This strongly suggests host recognition of tumor‐associated antigens. Characterization of cell surface antigens with murine monoclonal antibodies demonstrated shared reactivity between normal kidney tubular cells and renal carcinoma cells. Antibody A68.ll reacted strongly with all five cell lines. Antibody A80 bound to only UM‐RC‐3 and UM‐RC‐6.
Metastasis in the androgen‐lnsensitive Nb rat prostatic carcinoma system
Authors: Drago Joseph R. , Lombard Jeffrey S. 
Published: February 2007

AbstractThis unit has in the past evaluated the Nb rat prostatic adenocarcinoma model with respect to chemotherapies. Recently, this unit has been evaluating agents that may have a role in decreasing metastatic rate. The three androgen‐insensitive tumors, Nb Pr A.I. I, II, III, have been evaluated herein. Agents that have been used include indomethocin, heparin, heparin plus cortisone, and heparan sulfate (SP54). It has been shown that these agents do play a role in reducing the metastasis. In evaluation of Nb Pr A.I, I, control animals had a metastatic rate of 57%. In treatment with indocin, only 21% of the animals, three of 14 animals treated, had a metastasis, and treatment with heparin and cortisone resulted in one of 14 animals having metastasis. Similar observations were seen when treatment with SP54 and heparin was evaluated in the Nb Pr A.I. III; 18 and 27% of treatment group animals had metastasis, whereas 55% of control groups had metastasis. Similarly, in the Nb Pr A.I. II evaluation, control animals having a metastatic rate of 43 % had heparin plus cortisone and heparin alone, and this particular tumor model revealed complete resolution with no animals having metastatic disease. The majority of these agents have not effected tumor volume in terms of reduction as much as the best chemotherapeutic agents in this model system include cyclophosphamide and cis‐platinum.
Nb rat prostate adenocarcinoma model: Evaluation of the subrenal capsular assay system
Authors: Drago Joseph R. , Lombard Jeff 
Published: February 2007

AbstractDuring the course of the last 6 years, this laboratory unit has evaluated the Nb rat prostate adenocarcinoma model with respect to various chemotherapies. Heretofore, tumors were treated after they had been implanted in the subcutaneous space. The most active chemotherapeutic agents have been cyclophosphamide, adriamycin, and cis‐platinum. Herein, we report our initial experience utilizing the subrenal capsular assay. The advantage of this system is that one is able to determine the effect of chemotherapy in a very short period of time, ie, 7 days. This may be a method to save considerable expense and may serve as a useful predictor for potential future chemotherapeutic trials. In our assay systems, cyclophosphamide, adriamycin, cis‐platinum, and methotrexate did result in a significant decrease in the change in tumor volume. This change paralleled the results that we have seen in the past with the use of chemotherapy of the subcutaneous tumor nodules. Further exploration of this method is warranted from a time efficiency standpoint as well as a cost standpoint.
Malignant fibrous histiocytoma of solitary jejunal diverticulum
Authors: Singh C. , Gupta S. , Gupta S. 
Published: February 2007

AbstractA rare case of malignant fibrous histiocytoma arising from a solitary jejunal diverticulum leading to its perforation is described in a 37‐year‐old male. The patient presented with peritonitis and on exploration revealed perforation of a jejunal diverticulum containing a soft, friable mass. Biopsy from the mass revealed a malignant fibrous histiocytoma. This appears to be the first description in literature of a malignant fibrous histiocytoma with that particular localization.
Paget's disease of the anal mucosa in association with carcinoma demonstrating mucoepidermoid features
Authors: Giltman Larry I. , Osborne Pamela T. , Coleman Sidney A. , Uthman Edward O. 
Published: February 2007

AbstractA case of Paget's disease of the anal mucosa with an underlying carcinoma demonstrating mucoepidermoid features is reported. The histopathologic characteristics of both extramammary Paget's disease and mucoepidermoid carcinoma are noted. Special histochemical staining procedures were consistent with the diagnosis. The actual histogenesis of extramammary Paget's disease and mucoepidermoid carcinomas are controversial topics that are briefly discussed in this paper.
Giant intraductal papilloma of the breast: A case report
Authors: Roy I. , Meakins J. L. , Tremblay G. 
Published: February 2007

AbstractA case of an unusually large solitary intraductal papilloma of the breast is reported. This benign neoplasm presented as a 15‐cm breast mass, enlarging over a 2‐year period. The case illustrates that benign intraductal papilloma may rarely present as a large breast mass and therefore should be considered in the differential diagnosis of very large breast lesions.
Adult respiratory distress syndrome in a pregnant patient with a pheochromocytoma
Authors: Feldman Jerome M. 
Published: February 2007

AbstractFive weeks after developing spells of shortness of breath, headache, weakness and abdominal pain, a 29‐year‐old woman, who was in the 36th week of her third pregnancy developed adult respiratory distress syndrome (ARDS). Although the ARDS resolved after a cesarean section, her infant died at birth. Her “spells” continued until a left pheochromocytoma was diagnosed and resected 2 years later. If there are no other known inciting causes of ARDS in a pregnant patient, a pheochromocytoma should be ruled out with appropriate catecholamine determinations.
Systemic scleroderma and small cell carcinoma of the lung
Authors: Sarma Deba P. , Weilbaecher Thomas G. 
Published: February 2007

AbstractA 64‐year‐old man diagnosed to have systemic scleroderma for 1 year developed small‐cell carcinoma of the lung. Six additional cases obtained from the literature describing small‐cell carcinoma occurring in patients with scleroderma are reviewed.
Effectiveness of scalene node biopsy for staging of lung cancer in the absence of palpable adenopathy
Authors: Bernstein Michael P. , Ferrara John J. , Brown Louis 
Published: February 2007

AbstractScalene node biopsy (SNB) has been performed in patients with lung cancer at the Saint Francis Hospital and Medical Center if any of the following criteria has been present: (1) potentially resectable central lesion by chest radiograph, or (2) significant cardiac or pulmonary dysfunction, thereby placing the patient at increased risk for thoracotomy, or (3) a diagnosis of adenocarcinoma prior to SNB. Within these guidelines, a retrospective study was undertaken to determine the benefit of routine SNB in the absence of clinically palpable scalene nodes.In a 2‐year period beginning April 1981, 56 patients (37 males) presented with radiographic evidence of lung carcinoma without clinical evidence of scalene adenopathy. Approximately half of the lesions were of a central position. While the majority had symptoms of cough, hemoptysis, or chest pain, the primary lung lesion was identified on routine chest radiograph in 15 (27%). In only three was there no history of smoking, the remainder having at least a 20‐pack‐year history of cigarette use.Following a routine evaluation, 57 SNBs were performed alone or in concert with other surgical procedures (mediastinoscopy, bronchoscopy). Of these, only two (3.5%) were diagnostic and indicative of unresectable disease. While in one patient no additional procedure was performed, a simultaneous Chamberlain procedure in the other confirmed that the patient was unresectable for cure. In the remaining patients, tissue diagnosis of cancer was obtained through other maneuvers.Because of the low probability that SNB in the absence of clinically palpable nodes altered the management of lung cancer, we do not believe it to be of benefit in the diagnosis or staging of this disease.
An assessment of the risk of developing hyperparathyroidism and thyroid disorders subsequent to neck irradiation in middle‐aged women
Authors: Hedman Ingmar , Fjälling Martha , Lindberg Sture , Lundberg Lena‐Marie , Tisell Lars‐Erik 
Published: February 2007

AbstractWe investigated the occurrence of thyroid and parathyroid disorders in 100 women (age 66–70 years) irradiated for cervical spondylosis on average 25 years previously and in 100 control women of similar age. Hyperparathyroidism (HPT), proven by operation, was diagnosed in one patient of each group, and three additional cases were diagnosed biochemically among irradiated women. The difference in incidence is not significant. Nor was there any significant difference in incidence of thyroid disorders. No thyroid carcinoma was found in either group. Even if there is a moderate increase of HPT after neck irradiation in middle‐aged women the risk is not so great as to warrant organised follow‐up.