bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidant capacity and lipid composition of Brachionus plicatilis and Artemia enriched with a mixture of different post-processing formats of Navicula salinicola and Isochrysis galbana and lipid emulsions
Authors: Galindo A. , Pérez J. A. , Almansa E. , Rosa G. P. , Jiménez I. A. , Venuleo M. , Acosta N. G. , Rodríguez C. 
Published: March 2024

AbstractLive prey used by the aquaculture industry are usually poor in some essential nutrients including long chain polyunsaturated fatty acids (LC-PUFA) and must be enriched to improve their nutritional value prior to larval feeding. Standard enrichment protocols are commonly based on lipid emulsions, being associated to a high oxidative stress condition. The combination of microalgae and lipid emulsion can palliate this situation, where the oxidative stress can be partially compensated by the antioxidant compounds present in microalgae. The maintenance of living microalgae in culture facilities is laborious, and the produced biomass may present fluctuating properties, leading to a serious bottleneck in the cultivation of live prey. Hence, substitutes for live microalgae including pastes or dried formats are receiving increasing research attention due to its nutritional stability, longer shelf-life and easy handling. In this study four different microalgae formats combined with a lipid emulsion are tested as enrichment products for Brachionus plicatilis and Artemia. Thus, fresh, frozen and spray-dried Navicula salinicola (NFRE, NFRO and NSD, respectively), and spray-dried Isochrysis galbana (ISD) were mixed with a commercial oil concentrate (IncromegaTM) or a marine lecithin (LC 60®), and added for 5 h to the rotifer or Artemia culture media. The antioxidant capacity of the microalgae extracts and the live prey activity of antioxidant enzymes, peroxides index (PxI) and thiobarbituric acid reactive substances (TBARS) were evaluated. The lipid profile of microalgae formats and enriched live preys was also determined. Ethyl acetate extract was the most antioxidant active extract of all microalgae formats. In addition, overall, I. galbana seems to be better than any N. salinicola format for a more effective protection against oxidative stress and for live prey lipid enrichment. Both rotifer and Artemia cultured with the mixture of I. galbana and the lipid emulsion generally showed higher DHA/EPA and EPA/ARA ratios. Moreover, the combination of the microalgae with LC 60® lipid emulsion highly favored Artemia´s polar lipid and DHA incorporation. Among microalgae products, both spray-dried formats better enhanced live prey n-3 LC-PUFA content. Our results highlight the great potential of new microalgae-derived products to improve effectiveness of current live prey lipid enrichment protocols used in aquaculture.
Novel Fe-MOF@Cu/NiAl-LDH as Photo-Catalysts in Methane Bireforming: Effect of Preparation Strategy
Authors: El‑Hafiz Dalia R. Abd , Sakr Ayat A.‑E. 
Published: March 2024

AbstractIn this work, Fe-MOF@Ni/CuAl-LDH nanocomposites are developed for the first time in photocatalytic CO2/CH4 conversion to ultrapure formaldehyde. The reaction takes place in a dynamic (continuous flow) photosystem working under atmospheric pressure in presence of visible-light irradiation. The visible-light-active photocatalysts are prepared using two strategies in order to enhance both morphology and optical properties of the new composite. First strategy based on growing of MOF on the in-situ N2 exfoliated LDH using solvothermal reaction (FMNHT and FMCHT), where, the MOF is formed on surface and/or inside lamellar layer. The second based on formation of LDH around the previously prepared Fe-MOF via microwave assisted method (NFMMW and CFMMW). The data herein indicate that, both samples NFMMW and CFMMW, have LDH/MOF strong electronic coupling and exhibit an adjustable band gap share in improve charge generation/separation rate, reduce e−/h+ recombination rate and increase light absorption capacity. Those characteristics provide higher efficiency in photocatalytic CH4/CO2 conversion and give high selectivity toward ultrapure formaldehyde formation (99.9%).
Resistance Profile, Terbinafine Resistance Screening and MALDI-TOF MS Identification of the Emerging Pathogen Trichophyton indotineae
Authors: De Paepe Roelke , Normand Anne-Cécile , Uhrlaß Silke , Nenoff Pietro , Piarroux Renaud , Packeu Ann 
Published: March 2024

AbstractThe emerging pathogen Trichophyton indotineae, often resistant to terbinafine (TRB), is known to cause severe dermatophytoses such as tinea corporis and tinea cruris. In order to achieve successful treatment for these infections, insight in the resistance profile of T. indotineae strains and rapid, reliable identification is necessary. In this research, a screening medium was tested on T. indotineae strains (n = 20) as an indication tool of TRB resistance. The obtained results were confirmed by antifungal susceptibility testing (AST) for TRB following the in vitro broth microdilution reference method. Additionally, AST was performed for eight other antifungal drugs: fluconazole, itraconazole, voriconazole, ketoconazole, griseofulvin, ciclopirox olamine, naftifine and amorolfine. Forty-five percent of the strains were confirmed to be resistant to terbinafine. The TRB resistant strains showed elevated minimal inhibitory concentration values for naftifine and amorolfine as well. DNA sequencing of the squalene epoxidase-encoding gene showed that TRB resistance was a consequence of missense point mutations in this gene, which led to amino acid substitutions F397L or L393F. MALDI-TOF MS was used as a quick, accurate identification tool for T. indotineae, as it can be challenging to distinguish it from closely related species such as Trichophyton mentagrophytes or Trichophyton interdigitale using morphological characteristics. While MALDI-TOF MS could reliably identify ≥ 95% of the T. indotineae strains (depending on the spectral library), it could not be used to successfully distinguish TRB susceptible from TRB resistant strains.
Dissipativity of Stochastic Competitive Neural Networks with Multiple Time Delays
Authors: Tang Dandan , Wang Baoxian , Hao Caiqing 
Published: March 2024

AbstractThe $$(Q,R,S)-\gamma -$$

(
Q
,
R
,
S
)
-
γ
-

dissipative of stochastic competitive neural networks (SCNNs) with leakage delays and discrete delay is studied. Firstly, Lyapunov–Krasovskii functional is constructed, which studies the relationship between various types of time delays. Secondly, by using integral inequality technique, the linear matrix inequality (LMI) criterion of $$(Q,R,S)-\gamma -$$

(
Q
,
R
,
S
)
-
γ
-

dissipative in the mean square sense of SCNNs is obtained. Furthermore, the obtained LMI criterion is extended to the passivity in the mean square sense, stability in the mean square sense, $$(Q,R,S)-\gamma -$$

(
Q
,
R
,
S
)
-
γ
-

dissipative and passivity. Finally, the effectiveness of the obtained results are verified by numerical simulation.
Properties and practicability of convergence-guaranteed optimization methods derived from weak discrete gradients
Authors: Ushiyama Kansei , Sato Shun , Matsuo Takayasu 
Published: March 2024

AbstractThe ordinary differential equation (ODE) models of optimization methods allow for concise proofs of convergence rates through discussions based on Lyapunov functions. The weak discrete gradient (wDG) framework discretizes ODEs while preserving the properties of convergence, serving as a foundation for deriving optimization methods. Although various optimization methods have been derived through wDG, their properties and practical applicability remain underexplored. Hence, this study elucidates these aspects through numerical experiments. Particularly, although wDG yields several implicit methods, we highlight the potential utility of these methods in scenarios where the objective function incorporates a regularization term.
The Transition from Darcy to Nonlinear Flow in Heterogeneous Porous Media: I—Single-Phase Flow
Authors: Arbabi Sepehr , Sahimi Muhammad 
Published: March 2024

AbstractUsing extensive numerical simulation of the Navier–Stokes equations, we study the transition from the Darcy’s law for slow flow of fluids through a disordered porous medium to the nonlinear flow regime in which the effect of inertia cannot be neglected. The porous medium is represented by two-dimensional slices of a three-dimensional image of a sandstone. We study the problem over wide ranges of porosity and the Reynolds number, as well as two types of boundary conditions, and compute essential features of fluid flow, namely, the strength of the vorticity, the effective permeability of the pore space, the frictional drag, and the relationship between the macroscopic pressure gradient $${\varvec{\nabla }}P$$

∇

P

and the fluid velocity v. The results indicate that when the Reynolds number Re is low enough that the Darcy’s law holds, the magnitude $$\omega _z$$

ω
z

of the vorticity is nearly zero. As Re increases, however, so also does $$\omega _z$$

ω
z

, and its rise from nearly zero begins at the same Re at which the Darcy’s law breaks down. We also show that a nonlinear relation between the macroscopic pressure gradient and the fluid velocity v, given by, $$-{\varvec{\nabla }}P=(\mu /K_e)\textbf{v}+\beta _n\rho |\textbf{v}|^2\textbf{v}$$

-

∇

P
=

(
μ
/

K
e

)

v
+

β
n

ρ

|
v
|

2

v

, provides accurate representation of the numerical data, where $$\mu$$
μ
and $$\rho$$
ρ
are the fluid’s viscosity and density, $$K_e$$

K
e

is the effective Darcy permeability in the linear regime, and $$\beta _n$$

β
n

is a generalized nonlinear resistance. Theoretical justification for the relation is presented, and its predictions are also compared with those of the Forchheimer’s equation.
Expression and significance of SIRT6 in human peritoneal dialysis effluents and peritoneal mesothelial cells
Authors: Shi Shuai-Shuai , Zhang Yi-Qiang , Zhang Lu-Qi , Li Yun-Feng , Zhou Xiao-Shuang , Li Rong-Shan 
Published: March 2024

AbstractSirtuin 6 (SIRT6) can inhibit the fibrosis of many organs. However, the relationship between SIRT6 and peritoneal fibrosis (PF) in peritoneal dialysis (PD) remains unclear. We collected 110 PD patients with a duration of PD for more than 3 months and studied the influence of PD duration and history of peritonitis on SIRT6 levels in PD effluents (PDEs). We also analyzed the relationship between SIRT6 levels in PDEs and transforming growth factor beta 1 (TGF-β1), IL-6, PD duration, peritoneal function, PD ultrafiltration (UF), and glucose exposure. We extracted human peritoneal mesothelial cells (HPMCs) from PDEs and measured the protein and gene expression levels of SIRT6, E-cadherin, vimentin, and TGF-β1 in these cells. Based on the clinical results, we used human peritoneal mesothelial cells lines (HMrSV5) to observe the changes in SIRT6 levels and mesothelial-to-mesenchymal transition (MMT) after intervention with PD fluid. By overexpressing and knocking down SIRT6 expression, we investigated the effect of SIRT6 expression on E-cadherin, vimentin, and TGF-β1 expression to elucidate the role of SIRT6 in mesothelial-to-epithelial transition in PMCs. Results: (1) With the extension of PD duration, the influence of infection on SIRT6 levels in PDEs increased. Patients with the PD duration of more than 5 years and a history of peritonitis had the lowest SIRT6 levels. (2) SIRT6 levels in PDEs were negatively correlated with PD duration, total glucose exposure, TGF-β1, IL-6 levels, and the dialysate-to-plasma ratio of creatinine (Cr4hD/P), but positively correlated with UF. This indicates that SIRT6 has a protective effect on the peritoneum. (3) The short-term group (PD ≤ 1 year) had higher SIRT6 and E-cadherin gene and protein levels than the mid-term group (1 year < PD ≤ 5 years) and long-term group (PD > 5 years) in PMCs, while vimentin and TGF-β1 levels were lower in the mid-term group and long-term group. Patients with a history of peritonitis had lower SIRT6 and E-cadherin levels than those without such a history. (4) After 4.25% PD fluid intervention for HPMCs, longer intervention time resulted in lower SIRT6 levels. (5) Overexpressing SIRT6 can lead to increased E-cadherin expression and decreased vimentin and TGF-β1 expression in HPMCs. Knocking down SIRT6 expression resulted in decreased E-cadherin expression and increased vimentin and TGF-β1 expression in HPMCs. This indicates that SIRT6 expression can inhibit MMT in HPMCs, alleviate PF associated with PD, and have a protective effect on the peritoneum.
Sorptive Removal of 133Ba from Aqueous Solution Using a Novel Cellulose Hydroxyapatite Composite Derived from Cigarette Waste
Authors: Kusumkar Vipul Vilas , İnan Süleyman , Galamboš Michal , Viglašová Eva , Daňo Martin 
Published: March 2024

Abstract133Ba is a hazardous radionuclide generated during the operation of nuclear power plants. 133Ba needs to be removed from waste solutions because its half-life (10.55 years) and gamma energy pose a significant threat to human health. Cigarette butt (CB) is a waste that causes serious environmental problems. Various types of adsorbent materials are prepared based on the cellulose in its structure. The focus of the present study is to synthesize a novel composite material derived from CBs and to investigate its 133Ba removal capability. Microfibrillated cellulose (MFC) obtained from CBs was modified with hydroxyapatite (HAp) via the co‐precipitation method and converted into a composite adsorbent for the removal of 133Ba ions. Response surface methodology (RSM) based on Box‐Behnken Design (BBD) was employed for the examination of process variables such as initial pH, metal concentration, and adsorbent amount on 133Ba sorption. XRD and FTIR data confirmed the successful isolation of cellulose and the modification of the cellulose surface with HAp. The model F-value (100.04) and R2 (0.99) suggested that the proposed model was significant. Optimum conditions were determined as initial pH of 8, contact time of 134 min, and concentration of 0.01 mol/L, and the barium sorption capacity of MFC‐HAp was found to be 0.75 mmol/g under these conditions. The maximum monolayer barium sorption capacity was determined to be 2.92 mmol/g. Combining cellulose and HAp to be a novel composite adsorbent is useful for reusing CB waste and promising for removing 133Ba ions from aqueous solutions.
Enhancement of the Microstructure and Fatigue Crack Growth Performance of Additive Manufactured Titanium Alloy Parts by Laser-Assisted Ultrasonic Vibration Processing
Authors: Ojo Sammy A. , Manigandan Kannan , Morscher Gregory N. , Gyekenyesi Andrew L. 
Published: March 2024

AbstractPost-processing techniques can efficiently improve the surface quality, address microstructural defects, and optimize mechanical properties in additively manufactured parts. Surface severe plastic deformation processes such as ultrasonic nanocrystal surface modification (UNSM) integrated with localized laser heating were explored to enhance the surface properties, microstructure as well as the fatigue crack growth properties (FCG) in both directions of built. We successfully induced greater plasticity flow and achieved beneficial refinement of the surface grain structure by precisely controlling the heat and impact energies during surface treatment process. The LA-UNSM process, with the parameters utilized in this study considerably decreased the FCG rates of treated samples, when compared to samples without surface treatment. Improved fatigue crack growth properties along vertical and horizontal orientations after the post-process treatment were attributed to the induced-microstructural changes, improved surface quality, induced compressive residual stresses through gradient structure deformation layer that was prepared on the surface of the material. The fractographic analysis revealed that the cracks mostly originated from the pores in the as-produced state. This observation shows a clear correlation between the surface treatment performed and a substantial improvement in fatigue crack growth resistance.
Comparison of the efficacy of acupuncture with tuina with acupuncture-only in the treatment of peripheral facial paralysis: a network meta-analysis
Authors: Deng Xinyuan , Zhu Hao , Shi Luyan , Li Yanting , Shi Haiping , Wu Yicheng , Zhang Yu 
Published: March 2024

AbstractAt present, traditional Chinese medicine treatment is considered safe for treating peripheral facial paralysis (PFP). Acupuncture-only and acupuncture combined with tuina are widely used for this purpose. However, it is not clear whether acupuncture combined with tuina is better for treating PFP than acupuncture-only. Conventional meta-analysis and network meta-analysis were used to compare the clinical efficacies of acupuncture combined with tuina and acupuncture-only in the treatment of PFP. Randomized controlled trials (RCTs), with the subjects being patients with PFP and treatment interventions including acupuncture combined with tuina, acupuncture-only, tuina-only, placebo, single Western medicine, and steroids combined with other Western medicine were searched from both Chinese and English databases. The primary outcomes included Modified House–Brackmann (MHBN) scores and Sunnybrook Facial Grading System, whereas the secondary outcomes included cure time, Portmann scores, and physical function scale of Facial Disability Index, using conventional meta-analysis and network meta-analysis. The study included 22 RCTs with a sample size of 1814 patients. The results of conventional meta-analysis (MD = 16.12, 95%CI 13.13,19.10) and network meta-analysis (MD = 14.53, 95%CI 7.57,21.49) indicate that acupuncture combined with tuina was better than acupuncture-only in improving MHBN and shortening the cure time (MD = − 6.09, 95%CI  − 7.70, − 4.49). Acupuncture combined with tuina was the optimal therapy for improving MHBN (SUCRA was 100%) and shortening the cure time (SUCRA was 100%). The results of this meta-analysis indicate that acupuncture combined with tuina can significantly improve MHBN and shorten the cure time, compared with acupuncture-only. However, the current evidence is insufficient, and more high-quality clinical studies are needed.Registration: This study had been registered with PROSPERO (CRD42022379395).
A Comprehensive Investigation of Tenderization Methods: Evaluating the Efficacy of Enzymatic and Non-Enzymatic Methods in Improving the Texture of Squid Mantle — A Detailed Comparative Study
Authors: Altan Can Okan , Kocatepe Demet , Çorapcı Bengünur , Köstekli Bayram , Turan Hülya 
Published: March 2024

AbstractIn this study, enzymatic [papain (P), bromelain (B), and A. oryzae-derived fungal protease (FP); enzyme ratios: 0.012 (v/v), 38 °C, 50 min] and non-enzymatic [control (C; saline), mineral water (95%)–lemon juice (5%) (ML) (1/2:w/v), 38 °C, 50 min)] tenderizing methods on European squid mantle (Loligo vulgaris Lamarck, 1798) were investigated. Scanning electron microscope (SEM) imaging, water holding capacity (WHC), cooking loss (CL), total free amino acids (TFAA), total soluble protein (TSP), hydroxyproline (Hyp), and Fourier-transform infrared spectroscopy (FTIR) analyses were performed on uncooked samples. pH, water activity (aw), color, nutritional changes, amino acids (AA), total volatile basic-nitrogen (TVB-N), Warner-Bratzler shear (WBS), texture profile analysis (TPA), and sensory evaluations were performed on both uncooked and cooked samples. A significant decrease in protein content was observed in group P (12.86%) compared to untreated (U) squid (15.16%). During frying, group P absorbed more cooking oil (8.37%) than the other groups. A higher degree of hydrolysis was observed in the enzymatically tenderized groups than in non-enzymatic groups, and a shift in secondary protein structures in favor of random coils. Hydrolysis was confirmed by Hyp and AA analyses. The total AA content order was found as B < P < FP < C < ML < U. ML and FP groups have relatively higher total bitter and umami AA compositions, especially in uncooked samples. FP and ML groups had more favorable results across all analyses, especially in terms of the sensory results, nutritional values, and TPA results of cooked samples. It is concluded that both methods are very convenient regarding industrial usage.
To what extent is the effect of sensory processing sensitivity on distress mediated by resilience? Putting the diathesis-stress model to the test in a sample of gifted adults
Authors: Gucht Veronique De , Woestenburg Dion H. A. , Backbier Esther 
Published: March 2024

AbstractThe purpose of this prospective study was to examine (a) whether Sensory Processing Sensitivity (SPS) measured at baseline (T0) predicts distress at one year follow-up (T1), and (b) whether and in what way resilience mediates the effect of SPS on distress. The study sample consisted of gifted adults. A total of 738 respondents participated in the study at T0 and T1 (mean age of 44.86; 63.4% female). Structural Equation Modeling and logistic regression analysis were conducted. A high level of SPS at T0 predicted psychological (anxiety and depression) and somatic (physical symptoms and fatigue) distress at T1. As far as indirect effects are concerned, results depended upon whether we looked at the negative or positive higher-order dimension of SPS. A higher score on negative SPS was associated with lower resilience which in turn led to more distress, indicating that low resilience increased the negative impact of negative SPS on distress. In contrast, a higher score on positive SPS was related to more resilience, resulting in less distress, suggesting that in this case resilience had a buffering effect. As resilience is a buffer between SPS and distress, follow-up research could focus on psychological interventions aimed at increasing resilience.
The Case Against Organoid Consciousness
Authors: Croxford James , Bayne Tim 
Published: March 2024

AbstractNeural organoids are laboratory-generated entities that replicate certain structural and functional features of the human brain. Most neural organoids are disembodied—completely decoupled from sensory input and motor output. As such, questions about their potential capacity for consciousness are exceptionally difficult to answer. While not disputing the need for caution regarding certain neural organoid types, this paper appeals to two broad constraints on any adequate theory of consciousness—the first involving the dependence of consciousness on embodiment; the second involving the dependence of consciousness on representations—to argue that disembodied neural organoids are not plausible candidates for consciousness.