bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current Challenges and Opportunities for Advanced Nursing Education in The
United Arab Emirates
Authors: Salgado Arnel Bañaga , Kumardhas Vijaya 
Published: March 2024

Abstract:
The impact of the pandemic has shed light on the roles of nursing worldwide, as nurses who served in the frontline were affected severely and
significantly at the start of the COVID-19 pandemic. Most nurses bravely and courageously faced dangers, even death, to help patients confined in
various healthcare facilities. Eventually, the nursing profession emerged victorious after the healthcare system worldwide was brought to its knees,
almost collapsing the entire healthcare system in some countries, especially in Europe. As a part of countermeasures, all schools were forced to
close and reinvent themselves in educating students using the available technologies, internet, occasional volunteer exposure, and work in
government hospitals. The RAK College of Nursing (RAKCON) followed its actual schedule using all the university's resources, including online
examinations, Zoom, and Google Meet. At first, it looked like the quality of education, especially at the graduate level, was compromised. Still, the
students eventually became creative as they would do online research, meetings, and advising. The thesis defense was conducted online for at least
two consecutive years, i.e., 2020 and 2021. Yet, it does not show that the quality of the thesis output by the students is inferior. They improved as
students were obliged to keep track of the subject matter they chose to work on. As technology advances, the college is adjusting and looking for
opportunities everywhere, like expanding markets outside the UAE, improving alumni involvement and support, and its plan to initiate and open
doctoral nursing programs. RAKCON continuously believes that it can help develop innovation in the nursing and midwifery practice in the
country as it hopes to produce one nurse in every Emirati family.
Anti-Tumor Activity of Indole: A Review
Authors: Mohamed Momen R.F. , Shoman Mai E. , Ali Taha F. S. , Abuo-Rahma Gamal El-Din A. 
Published: March 2024

:
Generally, heterocyclic compounds are included in a large class of pharmacologically
active compounds. The indole scaffold in this category is widely distributed in nature and present
in many active compounds, especially anti-cancer agents. Due to its unique physicochemical and
biological properties, the indole platform has been considered a favorable scaffold in anti-cancer
drug design and development. Various indole compounds (synthetic, semisynthetic, and natural)
show remarkable anti-proliferative activity. According to the recent literature, this review describes
the role of indole scaffolds as anti-cancer agents. Indole was reported to induce anti-tumor activity
through multiple mechanisms, for example, Epidermal Growth Factor Receptors (EGFR), histone
deacetylase (HDAC), kinase, DNA-topoisomerases, and tubulin inhibition. The current review
focuses on some indole compounds with amazing effects against different types of cancers as there
are too many FDA-approved drugs, for example, osimertinib, alectinib, and anlotinib in NSCLC
treatment, panobinostat in multiple myeloma, midostaurin in acute myeloid leukemia treatment,
etc. Moreover, several compounds are still in clinical trials to treat different cancer types. Additionally, there are some oxindole derivatives with potent inhibition against different types of tumors, such as ovarian cancer, colorectal cancer, and prostate cancer. Different series of oxindoles
are promising and recommended for further studies due to their remarkable inhibition of tumor
cells. Accordingly, the collection of data on a pharmacologically significant motif might aid researchers in further employing indoles in developing novel anti-cancer drugs with potentially fewer
side effects and higher potency against this rapidly spreading disease.
Associations of Patients with Pericardial Effusion Secondary to
Light-Chain or Transthyretin Amyloidosis- A Systematic Review
Authors: Javed Nismat , Singh Kirit , Shirah Justin , Vittorio Timothy J. 
Published: March 2024

Background:
Pericardial effusion is associated with amyloidosis, specifically amyloid
light chain (AL) and transthyretin (ATTR) subtypes. However, the patients might present with different
clinical symptoms.

Objective:
To determine the characteristics and associations of patients with pericardial effusion owing
to either AL or ATTR amyloidosis.

Methods:
This study reviewed 26 studies from databases such as PubMed, MEDLINE, Web of Science,
Google Scholar and CINAHL databases after protocol registration. The data were analyzed in IBM
SPSS 21. Many statistical tests, such as Student t- and the Mann-Whitney U tests, were used. Multivariate
logistic regression analysis was also performed. A p-value<.05 was considered significant.

Results:
A total of 531 patients with pericardial effusion secondary to amyloidosis were included.
The mean age was 58.4±24.5 years. Most of the patients were male (72.9%). Common co-morbid conditions
included hypertension (16.8%) and active smoking (12.9%). The most common time from symptom
onset to the clinical presentation was less than 1 week (45%). ATTR amyloidosis was more common
in older patients (p<.05). Abdominal and chest discomfort were commonly associated with AL
and ATTR amyloidosis, respectively (p<.05). Patients with AL amyloidosis had a higher association
with interventricular septal thickening and increased posterior wall thickness (p<.05). First-degree atrioventricular
block, left bundle branch block (LBBB), and atrial fibrillation (AF) were more associated
with ATTR amyloidosis (p<.05).

Conclusion:
Pericardial effusion in patients with AL amyloidosis was associated with hypertrophic
remodeling, while conduction abnormalities were associated with ATTR amyloidosis.
Quantitative Comparison of Liver Volume, Proton Density Fat Fraction, and
Time Burden between Automatic Whole Liver Segmentation and Manual
Sampling MRI Strategies for Diagnosing Metabolic Dysfunction-associated
Steatotic Liver Disease in Obese Patients
Authors: Cao Di , Yang Yifan , Li Mengyi , Liu Yang , Yang Dawei , Xu Hui , Lv Han , Zhang Zhongtao , Zhang Peng , Jia Xibin , Yang Zhenghan 
Published: March 2024

Background::
The performance of automatic liver segmentation and manual sampling MRI strategies needs be compared to determine interchangeability.

Objective::
To compare automatic liver segmentation and manual sampling strategies (manual whole liver segmentation and standardized manual region of
interest) for performance in quantifying liver volume and MRI-proton density fat fraction (MRI-PDFF), identifying steatosis grade, and time
burden.

Methods::
Fifty patients with obesity who underwent liver biopsy and MRI between December 2017 and November 2018 were included. Sampling strategies
included automatic and manual whole liver segmentation and 4 and 9 large regions of interest. Intraclass correlation coefficient (ICC),
Bland–Altman, linear regression, receiver operating characteristic curve, and Pearson correlation analyses were performed.

Results::
Automatic whole liver segmentation liver volume and manual whole liver segmentation liver volume showed excellent agreement (ICC=0.97),
high correlation (R2=0.96), and low bias (3.7%, 95% limits of agreement, -4.8%, 12.2%) in liver volume. There was the best agreement
(ICC=0.99), highest correlation (R2=1.00), and minimum bias (0.84%, 95% limits of agreement, -0.20%, 1.89%) between automated whole liver
segmentation MRI-PDFF and manual whole liver segmentation MRI-PDFF. There was no difference of each paired comparison of receiver
operating characteristic curves for detecting steatosis (P=0.07–1.00). The minimum time burden for automatic whole liver segmentation was 0.32 s
(0.32–0.33 s).

Conclusion::
Automatic measurement has similar effects to manual measurement in quantifying liver volume, MRI-PDFF, and detecting steatosis. Time burden
of automatic whole liver segmentation is minimal among all sampling strategies. Manual measurement can be replaced by automatic measurement
to improve quantitative efficiency.
Hepatic Portal Venous Gas Associated with Acute Upper Gastrointestinal
Hemorrhage: A Case Report and Literature Review
Authors: Wang Chun , Li Yuanyuan , Yin Yunxiang , Xi Cheng , Su Meixian 
Published: March 2024

Background::
Hepatic portal venous gas (HPVG) is very rare; it is associated with multiple gastrointestinal etiologies, with pathophysiology not yet fully
understood. It is characteristically fast-progressing and has a high mortality rate. Treatment choice depends on the etiology, including conservative
and surgical management.

Case Presentation::
We report an adult patient (less than 25 years old) of HPVG combined with acute upper gastrointestinal hemorrhage, in which massive gas in the
hepatic portal vein system by computed tomography of the abdomen was rapidly dissipated by nasogastric decompression conservative
management.

Conclusion::
Nasogastric decompression can be an effective treatment approach for HPVG when timely surgical treatment is not required.
Feasibility of Weight-based Tube Voltage and Iodine Delivery Rate for
Coronary Artery CT Angiography
Authors: Wang Ying , Zhang Yan , Di Aihui , Wang Qizheng , Chen Yongye , Yuan Huishu , Lang Ning 
Published: March 2024

Purpose::
The objective of this study was to evaluate the feasibility of weight-based tube voltage and iodine delivery rate (IDR) for coronary artery CT
angiography (CCTA).

Methods::
A total of 193 patients (mean age: 58 ± 12 years) with suspected coronary heart disease indicated for CCTA between May and October 2022 were
prospectively enrolled. The subjects were divided into five groups according to body weight: < 60 kg, 60 – 69 kg, 70 – 79 kg, 80 – 89 kg, and ≥ 90
kg. The tube voltage and IDR settings of each group were as follows: 70 kVp/0.8 gI/s, 80 kVp/1.0 gI/s, 80 kVp/1.1 gI/s, 100 kVp/1.5 gI/s, and 100
kVp/1.5 gI/s, respectively. Objective image quality data included the CT value and standard deviation (noise) of the aortic root (AR), the proximal
left anterior descending branch (LAD), and the distal right coronary artery (RCA), as well as the signal-to-noise ratio and contrast-to-noise ratio of
the LAD and RCA. Subjective image quality assessment was performed based on the 18-segment model. Contrast and radiation doses, as well as
effective dose (ED), were recorded. All continuous variables were compared using either the one-way ANOVA or the Kruskal-Wallis rank sum
test.

Results::
No significant differences were observed in all objective and subjective parameters of image quality between the groups (P > 0.05). However,
significant differences in contrast and radiation doses were observed (P < 0.05). The contrast doses across the weight groups were 27 mL, 35 mL,
38 mL, 53 mL, and 53 mL, respectively, while the ED were 1.567 (1.30, 2.197) mSv, 1.53 (1.373, 1.78) mSv, 2.113 (1.963, 2.256) mSv, 4.22
(3.771, 4.483) mSv, and 4.786 (4.339, 5.536) mSv, respectively.

Conclusion::
Weight-based tube voltage and IDR yielded consistently high image quality, and allowed for further reduction in contrast and radiation exposure
during CCTA for coronary artery diseases.
Resorptive Root Features in Mandibular Molars with Pronounced Root
Divergence on Panoramic Radiographs: A Case Series
Authors: Jeon Su-Jin , Yeom Han-Gyeol 
Published: March 2024

Introduction:
The visualization and understanding of the details of the root configurations and root canal structure are essential prior to root canal treatment. This
study aimed to identify key indicators of pronounced root divergence between the distobuccal and distolingual roots in mandibular first molars by
highlighting common features observed in panoramic radiographs. These indicators can help predict the likelihood of encountering significant root
divergence before initiating endodontic treatment.

Case Presentation:
We present three cases in which panoramic radiographs displayed imaging features characteristic of root resorption in the distal root of the
mandibular first molars. However, subsequent periapical radiographs in case 1 and cone-beam computed tomography images in cases 2 and 3
revealed that the mandibular first molars were in normal condition, with pronounced root divergence but no evidence of root resorption.

Conclusion:
Panoramic radiographs depicting mandibular molar roots with a resorptive and unclear appearance may indicate the presence of severe root
divergence. In such cases, we strongly recommend additional cone-beam computed tomographic imaging to ensure precise diagnosis and facilitate
optimal treatment planning for endodontic procedures.
A Novel Machine-learning Model to Classify Schizophrenia Using Methylation Data Based on Gene Expression
Authors: Vijayakumar Karthikeyan A. , Cho Gwang-Won 
Published: March 2024

Introduction:
The recent advancement in artificial intelligence has compelled medical
research to adapt the technologies. The abundance of molecular data and AI technology has helped
in explaining various diseases, even cancers. Schizophrenia is a complex neuropsychological disease
whose etiology is unknown. Several gene-wide association studies attempted to narrow down the
cause of the disease but did not successfully point out the mechanism behind the disease. There are
studies regarding the epigenetic changes in the schizophrenia disease condition, and a classification
machine-learning model has been trained using the blood methylation data.

Methods:
In this study, we have demonstrated a novel approach to elucidating the molecular cause
of the disease. We used a two-step machine-learning approach to determine the causal molecular
markers. By doing so, we developed classification models using both gene expression microarray
and methylation microarray data.

Results:
Our models, because of our novel approach, achieved good classification accuracy with the
available data size. We analyzed the important features, and they add up as evidence for the glutamate
hypothesis of schizophrenia.

Conclusion:
In this way, we have demonstrated explaining a disease through machine learning
models.
Evidence of Neutralizing Antibodies Indicating the Cure of Patients Infected
with COVID-19 Within one Month of Infection
Authors: Abdulateef Yasir M. , Ayad Zainab N. , Noaman Haitham , Fadhel Marwa F. , Taha Mahammad Z. , Rafeeq Fatima M. , Salih Ahmed Y. 
Published: March 2024

Background:
During COVID-19 pandemic a major conflict facing the clinician
where to prove cure of the patients.

Aims:
The idea of confirming curability is based on clinical evaluation of the symptoms, laboratory investigations, and specific IgM, IgG anti-SARS-CoV2 antibodies.

Patients and Methods:
All patients had presented with clinical features of COVID-19 positive
PCR attended private clinic doctors consultant in internal medicine and infectious diseases, they
did investigations in Lagash land private medical laboratory in Baghdad investigated and
screened for COVID-19 by S. ferritin, D-dimer, Complete blood picture and LDH. All were
reevaluated in the first month of infection by clinical examination, retesting, and screening for
COVID-19 IgM IgG later to prove cure or evidence of viral infection in PCR negative cases.

Results:
All patients are of different ages with maximum years affected from adulthood till the
age of one hundred years. Male were 170(54.3%) patients and females were 143 (45.7%) total
313 patients (100%). Most are moderate socioeconomic status, with a significant number having
comorbidities.

Conclusion:
SARS COVID-19 IgM, IgG levels can be used to confirm a cure of the infection
Position Control of Electro-hydraulic Servo System Based on Repetitive
Control Strategy
Authors: Zhang Bing , Enyan Michael , Junsen Rao , Xinxing Zhang , Hongyu Liu 
Published: March 2024

Background:
When performing repetitive work in an electro-hydraulic servo system,
the expected tracking signals are often periodic signals, such as trigonometric functions. For this
kind of electro-hydraulic servo system, repetitive control is one of the most ideal control strategies.

Objective:
The objective of this patent technology is to improve the position-tracking performance
of the electro-hydraulic servo system and minimize tracking errors by designing and implementing
a repetitive control strategy.

Methods:
The study models an electro-hydraulic servo system, designs a stabilizing controller, and
develops a plug-in repetitive controller to enhance EHSS tracking. The regeneration spectrum is
used as a stability criterion, and performance is evaluated using statistical metrics like Mean Square
Error (MSE), Root Mean Square Error (RMSE), and standard deviation of the tracking error along
with tracking performance and steady-state error.

Results:
The developed controller, validated through simulation analysis and real-time experiments,
significantly reduces tracking error and enhances system position tracking accuracy,
demonstrating its effectiveness. For instance, the repetitive control strategy outperforms PID and
backstepping controllers at 30 mm with 0.5 Hz, achieving an error of 0.2 with an RMSE of 0.0924
and σ of 0.0878. Similar trends are observed at various test conditions, highlighting the consistent
and robust performance of the designed repetitive controller. Additionally, the designed repetitive
controller demonstrates an average improvement of 75.175% and 62.97% compared to the proportional-
integral-derivative and backstepping controllers, respectively.

Conclusion:
The designed controller provides technical support for position control of the electrohydraulic
servo system, achieves position control requirements, and significantly improves positioning
accuracy and response.
Supportive Care Needs in Chinese, Vietnamese, and Korean Americans With Metastatic Cancer: Mixed Methods Protocol for the DAWN Study
Authors: Kim Jacqueline H J , Kagawa Singer Marjorie , Bang Lisa , Ko Amy , Nguyen Becky , Chen Stokes Sandy , Lu Qian , Stanton Annette L 
Published: March 2024

Background
Asian Americans with metastatic cancer are an understudied population. The Describing Asian American Well-Being and Needs in Cancer (DAWN) Study was designed to understand the supportive care needs of Chinese-, Vietnamese-, and Korean-descent (CVK) patients with metastatic cancer.

Objective
This study aims to present the DAWN Study protocol involving a primarily qualitative, convergent, mixed methods study from multiple perspectives (patients or survivors, caregivers, and health care professionals).

Methods
CVK Americans diagnosed with solid-tumor metastatic cancer and their caregivers were recruited nationwide through various means (registries, community outreach newsletters, newspapers, radio advertisements, etc). Potentially eligible individuals were screened and consented on the web or through a phone interview. The study survey and interview for patients or survivors and caregivers were provided in English, traditional/simplified Chinese and Cantonese/Mandarin, Vietnamese, and Korean, and examined factors related to facing metastatic cancer, including quality of life, cultural values, coping, and cancer-related symptoms. Community-based organizations assisted in recruiting participants, developing and translating study materials, and connecting the team to individuals for conducting interviews in Asian languages. Health care professionals who have experience working with CVK patients or survivors with metastatic solid cancer were recruited through referrals from the DAWN Study community advisory board and were interviewed to understand unmet supportive care needs.

Results
Recruitment began in November 2020; data collection was completed in October 2022. A total of 66 patients or survivors, 13 caregivers, and 15 health care professionals completed all portions of the study. We completed data management in December 2023 and will submit results for patients or survivors and caregivers to publication outlets in 2024.

Conclusions
Future findings related to this protocol will describe and understand the supportive care needs of CVK patients or survivors with metastatic cancer and will help develop culturally appropriate psychosocial interventions that target known predictors of unmet supportive care needs in Chinese, Vietnamese, and Korean Americans with metastatic cancer.

International Registered Report Identifier (IRRID)
DERR1-10.2196/50032
Acceptability of a Self-Guided Lifestyle Intervention Among Young Men: Mixed Methods Analysis of Pilot Findings
Authors: Reading Jean Miki , Crane Melissa M , Guan Justin , Jackman Ronston , Thomson Maria D , LaRose Jessica Gokee 
Published: March 2024

Background
Young men are vastly underrepresented in lifestyle interventions, suggesting a need to develop appealing yet effective interventions for this population.

Objective
This study aimed to determine the acceptability of a self-guided lifestyle intervention designed specifically for young men (age: 18-35 years old).

Methods
Semistructured interviews and surveys were completed by 14 men following completion of a remotely delivered, 12-week lifestyle intervention. The intervention included 1 virtual group session, digital tools, access to self-paced web- and mobile-based content, and 12 weekly health risk text messages. We quantitatively and qualitatively examined young men’s experiences with the intervention components of a remotely delivered, self-guided lifestyle intervention targeting weight loss. Data were integrated using convergent mixed methods analysis.

Results
Men were a mean age of 29.9 (SD 4.9) years with a mean BMI of 31.0 (SD 4.5) kg/m2. The self-guided aspect was not acceptable, and a majority preferred more check-ins. Participants expressed a desire for a social aspect in future lifestyle interventions. All men found the focus on health risks appealing. A majority of men found the study-issued, Bluetooth-enabled scale acceptable.

Conclusions
Acceptability of the self-guided lifestyle intervention was perceived as suboptimal by young men. The findings highlight the need to add intervention components that sustain motivation and provide additional social support for young men.

Trial Registration
ClinicalTrials.gov NCT04267263; https://www.clinicaltrials.gov/study/NCT04267263
Tissue expression of porcine transient receptor potential mucolipin protein channels and their differential responses to porcine reproductive and respiratory syndrome virus infection in vitro
Authors: Xia Zhiqiang , Long Denggao , Hong Xinyi , Lan Ying , Xie Lixia 
Published: March 2024

Abstract

Introduction
Porcine reproductive and respiratory syndrome virus (PRRSV) infection results in a serious disease, posing a huge economic threat to the global swine industry. The transient receptor potential mucolipin proteins (TRPMLs) have been shown to be strongly associated with virus infection and other physiological processes in humans, but their tissue distribution and responses to PRRSV in pigs remain unknown.

Material and Methods
Quantitative reverse-transcription PCR analysis was undertaken to determine the optimal primer for TRPML expression detection and for quantifying that expression individually in different pig tissue samples. Meat Animal Research Center 145 (MARC-145) monkey kidney cells and the TRPML-specific activator mucolipin synthetic agonist 1 (ML-SA1) were used to reveal the relationship between TRPML and PRRSV-2 infection.

Results
The best primers for each TRPML gene used in a fluorescence-based quantitative method were identified and TRPML1 was found to be highly expressed in the kidneys and liver of pigs, while TRPML2 and TRPML3 were observed to be primarily expressed in the kidney and spleen tissues. The expression of TRPML2 was upregulated with the rise in PRRSV-2 infection titre but not the expression of TRPML1 or TRPML3, and ML-SA1 inhibited PRRSV-2 in a dose-dependent manner.

Conclusion
Our research revealed the gene expression of TRPMLs in pigs and identified that TRPML channels may act as key host factors against PRRSV infection, which could lead to new targets for the prevention and treatment of pig infectious diseases.