bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transradial cardiac catheterization in patients with coronary bypass grafts: Feasibility analysis and comparison with transfemoral approach
Authors: Sanmartin Marcelo , Cuevas Diogenes , Moxica Joaquin , Valdes Manuel , Esparza Jose , Baz Jose Antonio , Mantilla Ramon , Iñiguez Andres 
Published: March 2006

AbstractThe objective of this study was to analyze the feasibility and safety of transradial catheterization in patients with remote surgical cardiac revascularization. Selective catheterization of coronary bypass grafts might be more difficult and time‐consuming from the radial artery as compared to the femoral route. This special patient subset has been either excluded or underrepresented in previous studies. Retrospective review was made of 304 cardiac diagnostic procedures performed from January 2001 through December 2004 in patients with coronary artery bypass grafts in a single center. Patients had to be considered eligible for both transradial and transfemoral approach to be included. Cases with double internal mammary or gastroepiploic grafts were excluded. Selection of the arterial access was individualized according to operator preferences. Among diagnostic cases, transradial access was attempted as first choice in 151 cases (left radial in 133) and transfemoral in 154. Total procedural time (41 ± 22 vs. 40 ± 23 min), fluoroscopy time (15 ± 10 vs. 18 ± 13 min), and dye volume (180 ± 64 vs. 192 ± 73 ml) were similar. Crossover rates were 4.0% in the transradial group and 1.3% in transfemoral (P = 0.28). Only two patients in transradial group needed transfemoral access because of failure to catheterize a bypass graft. Transradial angiography of coronary bypass grafts can be performed with similar success rates as compared with transfemoral procedures and without a significant time delay. © 2006 Wiley‐Liss, Inc.
Percutaneous coronary intervention of or through saphenous vein grafts or internal mammary arteries: The impact of stents, adjunctive pharmacology, and multicomponent distal protection
Authors: Morrison Douglass A. , Thai Hoang , Goldman Steven , Felix Edward , Hernandez Joseph 
Published: March 2006

AbstractWe hypothesized that the use of stents and aggressive adjunctive pharmacotherapies has been associated with lower rates of complicating myocardial infarction (MI) and improved long‐term outcomes compared to either previous balloon‐only percutaneous coronary intervention (PCI) or atheroablative intervention for lesions of or through saphenous vein grafts (SVGs) and/or internal mammary arteries (IMAs). PCI of SVG has been complicated by relatively high rates of procedural MI and less favorable long‐term outcomes than native vessel PCI, stimulating the development and application of an array of technologies. This study was based on retrospective review of stent‐era (1999–2004) 5‐year experience of a single center with 95 SVG procedures in 85 patients and 20 IMA procedures in 20 patients. These cases were compared with the previously published experience of one of the operators during the balloon‐only period and literature review of the application of multiple technologies to SVG intervention, as well as consideration of the reoperation alternative. There was one in‐hospital death each in the SVG cohort (1%) and in the IMA cohort (5%). There were SIX procedural MIs (6%), defined by total CK > normal, and 19 procedural MIs (20%) based on troponin‐I > 1.0. Follow‐up has been from 4 months to 5 years (average, 2.5 years), with 91% survival and one late CABG in the IMA group. SVG PCI with stents and adjunctive pharmacotherapies is associated with relatively low rates of procedural MI and favorable long‐term outcomes. Published 2006 Wiley‐Liss, Inc.
Underlying aortic pathology and clinical health status determine success of endovascular stent‐grafting for descending thoracic aortic disease
Authors: Baumgart Dietrich , Eggebrecht Holger , Herold Ulf , Kuehl Hilmar , Piotrowski Jarowit , Niebel Wolfgang , Jakob Heinz‐Guenter , Erbel Raimund 
Published: March 2006

AbstractDespite advances in medical and surgical treatment, acute as well as chronic diseases of the thoracic aorta are still associated with a high mortality. For the descending thoracic aorta, endovascular stent‐graft placement competes with surgical therapy for clinical outcome. From July 1999 till December 2004, a total of 84 patients (64 ± 14 years) with aortic disease of the descending thoracic aorta were treated. Nine patients had acute (AAD) and 35 chronic aortic dissection (AD), 16 had thoracic aortic aneurysms (TAA), 21 had penetrating aortic ulcer (PAU), and 3 patients had traumatic dissection (trans). Initial clinical status was assessed using the American Society of Anesthesiologists (ASA) classification. Fifty‐three patients were in class 2, 16 in class 3, 8 in class 4, and 7 in class 5. Stent‐graft placement was performed in the cardiac catheterization laboratory with the patient under general anesthesia. Technical success was obtained in 81/84 patients (96%). Within 30 days, seven patients (8%) died, four of them due to aortic rupture. In 14 patients, additional stent‐grafts had to be implanted due to type I endovascular leakage (n = 5) or additional entry site adding up to a total of 107 implanted stent‐grafts. During a follow‐up period of 21 ± 18 months, 17 additional patients died (22%). In10 patients, death was disease‐ or procedure‐related (13%). This long‐term mortality depended on the underlying disease and was highest in the group with TAA (45%) followed by AAD (38%) and AD (18%). Patients in ASA class 4 and 5 had a significantly worse outcome. No aortic‐related death occurred among patients with PAU or traumatic transsections. Overall, there was only one transient neurological deficit. Endovascular stent‐graft placement has acceptable results in the treatment of patients with disease of the descending thoracic aorta. The outcome strongly depends on the underlying aortic pathology and the clinical health status of the patients. Randomized trials are necessary in order to establish the exact value of this new therapeutic option. © 2006 Wiley‐Liss, Inc.
Three‐year follow‐up after intracoronary beta‐radiation therapy for in‐stent restenosis
Authors: Iofina Ekaterina , Radke Peter , Schubert Daniela , Langenberg Roswitha , Blindt Rüdiger , Hanrath Peter , Hoffmann Rainer 
Published: March 2006

AbstractBackground: Most studies that proved intracoronary radiation therapy (IRT) to be highly effective to reduce recurrent restenosis after treatment of in‐stent restenosis (ISR) have looked at time periods up to 12 months. Whether the beneficial effect from radiation is sustained during long‐term follow‐up remains a concern. This study sought to evaluate the effectiveness of IRT using a β‐emitter during a 3‐year follow‐up period. Methods: One hundred twenty‐eight consecutive symptomatic patients (mean age, 63 ± 11 years) with 134 in‐stent restenotic lesions were treated for ISR with IRT (noncentred β‐emitter, Novoste; radiation dosis 21.1 ± 3.1 Gy). Six‐month angiographic follow‐up was obtained in 104 patients (81%) with 105 lesions (78%). All patients underwent 36‐month clinical follow‐up. Results: Six‐month angiographic restenosis rate was 22% in stent (29% in lesion) with an in‐stent late loss of 0.49 ± 0.62 mm. Target lesion resvascularization (TLR) at 6‐month follow‐up was performed in 23 cases (18%). MACE (death, myocardial infarction, and target vessel revascularisation) was observed in 24 patients (19%). At 36‐month follow‐up, TLR increased to 36 cases (28%) and MACE was observed in 47 patients (37%). In a multivariate analysis, minimal lumen diameter before treatment of ISR using IRT was the only predictor of recurrent TLR at 36 months (OR = 0.131; 95% CI, 0.068–0.254; p = 0.002). In a subgroup of patients (N = 15) without restenosis at 6‐month angiography but with clinically driven recurrent late angiography (mean, 18 ± 7 months); in‐lesion late loss increased from 0.47 ± 0.54 mm at 6 months to 1.27 ± 0.76 mm at repeated angiography (p = 0.005). Conclusion: There is a considerable number of delayed recurrent restenosis post IRT for ISR. This is due to ongoing late loss more than 6‐month post IRT. The minimal lumen diameter before IRT predicts the need for recurrent TLR at 36 months. © 2006 Wiley‐Liss, Inc.
Correlates and outcomes of retroperitoneal hemorrhage complicating percutaneous coronary intervention
Authors: Ellis Stephen G. , Bhatt Deepak , Kapadia Samir , Lee David , Yen Michael , Whitlow Patrick L. 
Published: March 2006

AbstractBACKGROUND: Retroperitoneal hemorrhage (RPH) is an infrequent but occasionally fatal complication of percutaneous coronary intervention (PCI). Therefore, it has been studied in relatively small numbers of patients. METHODS: Prospectively collected data on 28,378 consecutive patients treated between 1992 and 2003 were examined, supplemented by a date‐based case control cohort study (76 RPH and 76 non‐RPH patients) to examine elements not routinely recorded prospectively. Independent correlates of RPH were determined using logistical regression analysis. RESULTS: One hundred sixty‐three patients (0.57%) developed RPH; of these 73.5% required blood transfusions and 10.4% expired during hospitalization (P < 0.001 for both compared with patients without RPH). RPH was independently associated with femoral artery sheath placement superior to the inferior epigastric artery (P < 0.001), female sex (P < 0.001), use of Angioseal™ Device (P < 0.001), glycoprotein IIb/IIIa inhibitor use (P = 0.001), and patient presentation with the acute myocardial infarction (P = 0.035), and was inversely related to patient weight (P = 0.014). Of the 17 patient deaths, 6 were directly related to RPH, 2 of which occurred in association with delays in resuscitation efforts consequent to attempts to obtain diagnostic confirmation with CT imaging. CONCLUSIONS: RPH remains an infrequent but serious complication of PCI. Appropriate management of the femoral access site and the patient once this complication is suspected may minimize adverse outcomes. © 2006 Wiley‐Liss, Inc.
Utilization of a pressure sensor guidewire to measure bileaflet mechanical valve gradients: Hemodynamic and echocardiographic sequelae
Authors: Doorey Andrew J. , Gakhal Mandip , Pasquale Michael J. 
Published: March 2006

AbstractSuspected prosthetic valve dysfunction is a difficult clinical problem, because of the high risk of repeat valvular surgery. Echocardiographic measurements of prosthetic valvular dysfunction can be misleading, especially with bileaflet valves. Direct measurement of trans‐valvular gradients is problematic because of potentially serious catheter entrapment issues. We report a case in which a high‐fidelity pressure sensor angioplasty guidewire was used to cross prosthetic mitral and aortic valves in a patient, with hemodynamic and echocardiographic assessment. This technique was safe and effective, refuting the inaccurate non‐invasive tests that over‐estimated the aortic valvular gradient. © 2006 Wiley‐Liss, Inc.
Comparison of the effectiveness of sirolimus‐ and paclitaxel‐eluting stents for small coronary artery lesions
Authors: Park Kyoung‐Ha , Park Seong‐Wook , Hong Myeong‐Ki , Kim Young‐Hak , Lee Bong‐Ki , Park Duk‐Woo , Choi Bong‐Ryong , Kim Mi‐Jeong , Park Kyoung‐Min , Lee Cheol Whan , Cheong Sang‐Sig , Kim Jae‐Joong , Park Seung‐Jung 
Published: March 2006

AbstractBackground: The sirolimus‐eluting stent (SES) and the paclitaxel‐eluting stent (PES) reduce restenosis in small coronary artery lesions. However, it is not clear which of these stents is superior in terms of clinical outcomes. Methods: The authors retrospectively examined 197 patients with 245 de novo small coronary artery lesions (≤≤2.75 mm) that were treated with either the SES (156 lesions) or the PES (89 lesions). Six‐month angiographic restenosis rates and the 9‐month target lesion revascularization (TLR) rates were compared between the two groups. Results: In terms of baseline clinical and angiographic parameters, the two groups well matched together. Six‐month angiographic follow‐up was performed on 170 patients (86.3%), comprising 135 SES lesions (86.5%) and 76 PES lesions (85.4%). At 6‐month angiographic follow‐up, the late lumen loss was less in the SES group than in the PES group (0.29 ± 0.42 vs. 0.69 ± 0.63 mm, P < 0.01). Therefore, the SES group showed a lower rate of angiographic restenosis than the PES group (6.7% vs. 27.7%, P < 0.01). At 9 months there were no deaths or myocardial infarctions in either group. The 9‐month TLR rate was lower in the SES group than in the PES group (3.3% vs. 14.4%, P < 0.01). The Kaplan‐Meier estimate of freedom from TLR at 9 months was 96.7% for the SES patients and 86.5% for the PES patients (P < 0.01). Conclusions: The SES treatment may be superior to the PES treatment in terms of long‐term clinical and angiographic outcomes in patients with small coronary artery lesions. © 2006 Wiley‐Liss, Inc.
The Challenge of the So‐Called Electron Configurations of the Transition Metals
Authors: Wang S. G. , Qiu Y. X. , Fang H. , Schwarz W. H. E. 
Published: March 2006

AbstractQuite different meanings are attached by chemists to the words element, atom, orbital, order of orbitals or configurations. This causes conceptual inconsistencies, in particular with respect to the transition‐metal elements and their atoms or ions. The different meanings will here be distinguished carefully. They are analyzed on the basis of empirical atomic spectral data and quasi‐relativistic density functional calculations. The latter are quite reliable for different average configuration energies of transition‐metal atoms. The so‐called “configurations of the chemical elements”, traditionally displayed in periodic tables, are the dominant configurations of the lowest spin‐orbit levels of the free atoms. They are chemically rather irrelevant. In many‐electron systems the ns and np AOs are significantly below the more hydrogen‐like nd ones. Even (n+1)s is below nd for all light neutral atoms from C onwards, but only up to the first elements of the respective long rows! The most common orbital order in transition‐metal atoms is 3p ≪ 3d < 4s etc. The chemically relevant configuration in group g is always dg instead of dg−2 s2. Conceptually clear reasoning eliminates apparent textbook inconsistencies between simple quantum‐chemical models and the empirical facts. The empirically and theoretically well‐founded Rydberg (n−δl) rule is to be preferred instead of the historical Madelung (n+l) rule with its large number of exceptions.
A New Triferrocenyl‐tris(hydroxymethyl)aminomethane Derivative as a Highly Sensitive Electrochemical Marker of Biomolecules: Application to the Labelling of PNA Monomers and Their Electrochemical Characterization
Authors: Baldoli Clara , Rigamonti Clara , Maiorana Stefano , Licandro Emanuela , Falciola Luigi , Mussini Patrizia Romana 
Published: March 2006

AbstractWe have designed and synthesised a new organometallic molecule containing three ferrocene groups for use as a highly sensitive electrochemical marker in biological assays. This trisferrocene derivative was conjugated to different PNA monomers, and the electrochemical activities of the conjugates were extensively investigated in organic solvents, in view of their potential diagnostic applications. The results showed that the introduction of a trisferrocene unit on the PNA monomer triples the current signal in comparison with the monoferrocene‐labelled one. Despite their greater molecular complexity, trisferrocene‐conjugated PNA monomers are even more electrochemically active than the reference ferrocene. By using differential pulse voltammetry (DPV), the detection limit can reach 10−8 M in acetonitrile solution. These results are a good premise for the use of the trisferrocene unit as an effective electrochemical probe for biomolecules.
Synthetic Approaches to Hydroazulenes and Guaianes through [4 + 3] Cycloadditions of Oxyallyl Intermediates
Authors: Föhlisch Baldur , Flogaus Robert , Henle Gerhard H. , Sendelbach Stefan , Henkel Sonja 
Published: March 2006

AbstractBuilding blocks for syntheses of guaiane and secoguaiane sesquiterpenoids were prepared by the title reaction. 4‐(3‐Methylfuran‐2‐yl)butan‐2‐one (1) was obtained in five steps from methyl 3‐methylfuran‐2‐carboxylate (4), and treatment of 1 with pentachloroacetone and sodium 2,2,3,3‐tetrafluoropropoxide in 2,2,3,3‐tetrafluoropropan‐1‐ol produced a [4 + 3] cycloadduct that was dechlorinated without prior isolation to give the oxabicyclic diketone 2 in a low yield. A better route to diketone 2 was via the oxabicycle 10b, prepared in a high yield from 2‐(but‐3‐en‐1‐yl)‐3‐methylfuran (9) and pentachloroacetone, followed by dechlorination. Treatment of 2 with dilute methanolic potassium hydroxide resulted in the cleavage of the oxa bridge, with formation of 3,8‐dimethylazulen‐4‐ol (11). Catalytic hydrogenation of 2 afforded the saturated oxabicyclic diketone 14, intramolecular aldol condensation of which gave the tricycle 15. The oxa bridge of the oxatricyclic enone 15 was cleaved by hydrogenolysis in the presence of palladium/carbon catalyst to give the 6‐hydroxydecahydroazulen‐4‐one 16. Treatment of isobutyl trichloromethyl ketone (20) with furan 9 and sodium trifluoroethoxide in trifluoroethanol eventually gave the 2‐chlorooxabicycle 22. This solvolysis product was dechlorinated to furnish the oxabicyclic trifluoroethoxy ketone 24 as a single product that was subjected to the sequence of transformations used for 10b. X‐ray structure analysis of the resulting saturated diketone 26 established the endo configuration of the isopropyl group. Finally, aldol cyclization of 26 furnished the guaiane derivative 27. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Synthesis and Photophysical Properties of a Pyrazolino[60]fullerene with Dimethylaniline Connected by an Acetylene Linkage
Authors: Gouloumis Andreas , Oswald Frédéric , El‐Khouly Mohamed E. , Langa Fernando , Araki Yasuyuki , Ito Osamu 
Published: March 2006

AbstractA new triad based on pyrazolino[60]fullerene and a conjugated dimethylaniline group has been synthesized by a copper‐free Sonogashira cross‐coupling reaction using microwave irradiation as the source of energy. The electrochemical and photophysical properties of the triad were systematically investigated by techniques such as time‐resolved fluorescence and transient absorption spectroscopy. Charge separation via the excited singlet state of the C60 moiety was confirmed in polar and nonpolar solvents and competes with triplet formation of the C60 moiety. The charge‐separated state persisted for 91 ns. Such long lifetimes are characteristic of long distances between the radical anion of the pyrazolino[60]fullerene derivative and the radical cation of the dimethylaniline moiety. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Macrocyclic Cyclo[n]malonates – Synthetic Aspects and Observation of Columnar Arrangements by X‐ray Crystallography
Authors: Chronakis Nikos , Brandmüller Torsten , Kovacs Christian , Reuther Uwe , Donaubauer Wolfgang , Hampel Frank , Fischer Felix , Diederich François , Hirsch Andreas 
Published: March 2006

AbstractA variety of achiral and chiral macrocyclic oligomalonates were synthesised in a one‐step procedure through condensation of malonyl dichloride with α,ω‐diols. We have investigated the applicability of this method by varying the length and type of the spacers in the diol. Product distribution analysis revealed that the preferential formation of monomeric, dimeric, or trimeric macrocyclic malonates can be controlled by choosing diols with specific spacers connecting the hydroxy groups. Of special interest are the macrocyclic bismalonates, as they show pronounced crystallisability and arrange into columnar motifs in the solid state. They feature distinctive dihedral angles: all ester moieties adopt anti conformations whereas the planes of the carboxy moieties of each malonate residue arrange in an approximately orthogonal fashion. The latter geometry is enforced by the macrocyclic structures, as revealed by a conformational search in the Cambridge Structural Database. The X‐ray diffraction data show that C=O···H–C, and C–O···H–C hydrogen bonds stabilise the columnar arrangement of the dimeric rings with formation of tubular assemblies. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Synthesis of Amino‐L‐Lyxose Phosphonates as Fucosyl‐Phosphate Mimics
Authors: Chevrier Carine , Le Nouën Didier , Defoin Albert , Tarnus Céline 
Published: March 2006

AbstractSome reactions of nitrone 4 are described, namely the nucleophilic addition of dialkyl phosphites, HOP(OR)2, 5a–c or of diethyl methylphosphonate 8 and the dipolar [2+3] cycloaddition of vinylphosphonate 11. Chemical transformations led to 4‐amino‐L‐fucose derivatives bearing a phosphonate group in the 1α position linked to the pyrrolidine ring through a chain of 0–2 carbon atoms. The target compounds proved to be good‐to‐excellent α‐L‐fucosidase inhibitors. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Metalated 1‐(p‐Methoxybenzyl)pyrazole: A Structural Chameleon
Authors: Ondi Levente , Schlosser Manfred 
Published: March 2006

AbstractWhen treated with either butyllithium or lithium diisopropylamide, 1‐(p‐methoxybenzyl)pyrazole undergoes metalation at the exocyclic α‐position but mutates to the 5‐lithio species in the course of few minutes or hours. Trapping the intermediates with a rapidly reacting electrophile such as chlorotrimethysilane or carbon dioxide offers selective access to either of the two possible regioisomers. On the other hand, the relatively inert 1‐iodobutane and butyl trifluoromethanesulfonate (“triflate”) inevitably give rise to product mixtures, as the 5‐lithio species is more slowly intercepted than it can revert to the α‐metallomer by a rapid, though intermolecular, dynamic equilibration process. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Top‐down influences on lexical selection during spoken word production: A 4T fMRI investigation of refractory effects in picture naming
Authors: de Zubicaray Greig , McMahon Katie , Eastburn Mathew , Pringle Alan 
Published: March 2006

AbstractSpoken word production is assumed to involve stages of processing in which activation spreads through layers of units comprising lexical‐conceptual knowledge and their corresponding phonological word forms. Using high‐field (4T) functional magnetic resonance imaging (fMRI), we assessed whether the relationship between these stages is strictly serial or involves cascaded‐interactive processing, and whether central (decision/control) processing mechanisms are involved in lexical selection. Participants performed the competitor priming paradigm in which distractor words, named from a definition and semantically related to a subsequently presented target picture, slow picture‐naming latency compared to that with unrelated words. The paradigm intersperses two trials between the definition and the picture to be named, temporally separating activation in the word perception and production networks. Priming semantic competitors of target picture names significantly increased activation in the left posterior temporal cortex, and to a lesser extent the left middle temporal cortex, consistent with the predictions of cascaded‐interactive models of lexical access. In addition, extensive activation was detected in the anterior cingulate and pars orbitalis of the inferior frontal gyrus. The findings indicate that lexical selection during competitor priming is biased by top‐down mechanisms to reverse associations between primed distractor words and target pictures to select words that meet the current goal of speech. Hum Brain Mapp, 2006. © 2006 Wiley‐Liss, Inc.