bluuebunny/crossref_metadata_2025_split huggingface dataset:
Needle biopsies in breast cancer diagnosis: Techniques in search of an audience
Authors: Smeets Harm J. , Saltzstein Sidney L. , Meurer William T. , Pilch Yosef H. 
Published: February 2007

AbstractFine‐needle aspiration cytology and Tru‐cut needle biopsy have been described as excellent techniques in the diagnosis of breast cancer. Responses to questionnaires sent to 90 pathologists in San Diego County, however, proved that in only 2‐10% of all new breast cancer cases are these techniques being used to make the initial diagnosis. This paradox appeared to be due mainly to a reluctance of clinicians to use these techniques. However, There also appeared to be a lack of confidence and training among pathologists in interpreting aspiration cytology specimens. in the authors' and other pathologists' opinion, reviewing breast aspiration cytology specimens requires special training and regular exposure to such material, whereas Tru‐cut needle biopsy specimens can be interpreted accurately by almost any pathologist without special training. The results of our own series of needle biopsies and aspiration cytology in the diagnosis of breast cancer are presented and compared to those reported in several other published reports. These data indicate that approximately 90% (89% in our series) of all palpable breast cancers can be diagnosed by needle biopsy techniques.
Association of inflammatory bowel disease (IBD) with indolent soft‐tissue sarcomas: Report of two cases and review of literature
Authors: Israel Karyn J. , Nissenblatt Michael J. 
Published: February 2007

AbstractTwo patients with inflammatory bowel disease (IBD) and indolent forms of soft‐tissue sarcomas (extraosseous osteogenic sarcoma and desmoid tumor) are presented. The literature is reviewed regarding these tumors, which have not previously been recognized in association with IBD. Despite the well‐established relationship between IBD and neoplasms of epithelial and lymphoreticular origin, There have been limited data in this context pertaining to mesenchymal tumors. Two preceding reports have described the coexistence of IBD with another form of soft tissue sarcoma (Kaposi's sarcoma). Given that this relationship has now been observed in four cases, The possibility that soft‐tissue sarcoma and IBD do not coexist fortuitously must be considered. This suggestion is raised in light of the rare incidence of these disorders, The limited understanding of factors governing their expression, and the known association of IBD with other forms of neoplasia.
Influence of omentum transposition on experimental tumors
Authors: Chalmers P. J. , Newing R. K. 
Published: February 2007

AbstractIt has been observed that in human breast cancer transposition of the greater omentum to cover the excision site after removal of recurrent tumor appears to inhibit further recurrences at the site, without affecting spread to other sites. To establish an experimental model of this, inbred rats were transplanted in two sites on the chest with pieces of either an epitholioma or a mammary tumor. A flap of the omentum was then drawn through the peritoneal wall and then secured over one of the implants. in one group, this omentoplasty was carried out 1 week after tumor implantation. in most rats, The tumor in contact with the omentum was actually larger than the control, in contrast to the clinical observations. in many animals, Theomentum was also a route of metastasis of the tumor.
The morbidity of perineal wounds following abdominoperineal resection for rectal carcinoma
Authors: Petrelli Nicholas , Rosenfield Lorne , Herrera Lemuel , Mittelman Arnold 
Published: February 2007

AbstractThe clinical charts of 44 patients who underwent an abdominoperineal resection for adenocarcinoma of the rectum at Roswell Park Memorial Institute were retrospectively reviewed. The morbidity of an open perineal wound versus the closed perineal wound were evaluated. All of the patients received a Nichol's bowel preparation and following the abdominal portion of the dissection reperitonealization of the pelvic floor was performed. The overall morbidity for the open perineal wounds was 21% compared to a morbidity of 63% for the perineal wounds that were closed primarily. The mean length of hospitalization from the time of abdomino‐perineal resection was 21 days for the open perineal group and 22 days for the closed perineal group. The inclusion of wound sinus tracts in our morbidity assessment may explain the higher complication rate of the closed wound group than previously reported in the literature. This retrospective review emphasizes that the morbidity of the open perineal wound following abdominoperineal resection has been overemphasized. One is trading a potentially increased incidence of septic wound complications in the closed perineum for a protracted wound closure in the open perineum.
Seven cases of pelvic exenteration combined with sacral resection for locally recurrent rectal cancer
Authors: Takagi Hiroshi , Morimoto Takeshi , Hara Suguru , Suzuki Ryoji , Horio Shizuka 
Published: February 2007

AbstractLocal recurrence of rectal cancer following abdominoperineal resection is rarely amenable to limited resection. Carcinoembryonic antigen assay is valuable for diagnosing most recurrent rectal cancers, but it is inadequate for early detection. Pelvic computed tomography examination is very valuable for the early detection and localization of recurrence in relation to pelvic structures and can also serve as a guide in percutaneous needle biopsy of the tumor.Seven patients with deeply invading recurrent lesions underwent pelvic exenteration combined with sacral resection. The ileal segment conduit was used for ureteral urinary diversion. The mean operation time and blood loss were 8.8 hours and 6,200 ml, respectively. No operative deaths were encountered. One patient is alive 22 months postoperatively with no evidence of disease, and another patient is alive 32 months postoperatively with pelvic wall recurrence. This procedure seems a reasonable treatment for palliation and full recovery in certain patients.
Chemotherapy in invasive thymomas: Five case reports
Authors: Donovan Patrick J. , Foley John F. 
Published: February 2007

AbstractWe treated 5 cases of invasive thymomas with single agent and combination chemotherapy. A carcinoid tumor of the thymus had a 13‐month objective response to monthly courses of a combination of DTIC, adriamycin, cytoxan, and vincristine. A second case of carcinoid achieved stabilization of disease with a combination of adriamycin, cyclophosphamide, and DTIC for 9 months and subsequently 10 months, with fluorouracil and methotrexate. A case of thymoma had stabilization of disease for 14 months with oral cytoxan and prednisone.
Aggressive squamous cell carcinoma of the skin after chronic lymphocytic leukemia
Authors: Bridges Nancy , Steinberg J. J. 
Published: February 2007

AbstractWe report two cases of squamous cell carcinoma (SCC) of the skin subsequent to chronic lymphocytic leukemia (CLL). Both cases had an unusually aggressive course for a nonmelanoma skin malignancy with extensive metastases in both, resulting in death in one patient. A literature review supports the likelihood of an increased incidence of SCC in patients with CLL. Though the mechanism is unknown, immunosuppression may play a central role. We urge patients with CLL to avoid exposure to direct sun. Any questionable skin lesion should be biopsied early, and completely excised if it is a tumor. The patient should also be examined thoroughly for metastatic disease via subsequent follow‐up visits.
Coexisting leiomyosarcoma and transitional cell carcinoma of the urinary bladder
Authors: Chen Karl T. K. 
Published: February 2007

AbstractA rare case of coexisting sarcoma and carcinoma of the urinary bladder is reported and the literature is reviewed. Because of the differences in the histogenesis and prognosis, such cases should be differentiated from cases of carcinosarcoma of the urinary bladder.
Spontaneous regional lymph node metastases of three variants of the B16 melanoma: Relationship to primary tumor size and pulmonary metastas
Authors: Nathanson S. David , Haas Gabriel P. , Mead Marilee J. , Lee Min 
Published: February 2007

AbstractWe studied the patterns of spontaneous regional lymph node metastases of three variants (Fl, F10, and BL6) of the B16 melanoma in C57BL/6 mice and related the incidence to primary tumor size and pulmonary metastases. The incidence of regional lymph node and pulmonary metastases correlated with increasing primary tumor size (p ⩽ 0.0001). The incidence of pulmonary metastases in mice whose regional lymph nodes did not contain tumor also correlated with increasing primary tumor size (p ⩽ 0.0001). This propensity for direct hematogenous spread was more apparent in BL6 tumors than in F1 and F10 tumors (p ⩽ 0.0001). BL6 tumors also metastasized to regional nodes at smaller primary tumor sizes (p ⩽ 0.04). Heterogeneous variants that metastasize earlier to regional lymphatic and hematogenous sites dictates the natural history of the primary tumor. Whether prophylactic lymphadenectomy for melanomas is therapeutic may depend on dissemination‐related phenotypic characteristics.
Thyroid cancer mimicking thyroiditis
Authors: van der Sluis R. F. , Wobbes Th. , Schoots F. J. 
Published: February 2007

AbstractTwo patients with thyroid cancer, who presented with clinical and biochemical features of subacute thyroiditis, are reported, Confusion in diagnosis delayed therapy from 3 to 8 months. The relation between thyroiditis and thyroid cancer is discussed.
Extracardiac rhabdomyoma: A report of two cases
Authors: Pradhan S. A. , Rajpal R. M. , Shrikhande S. S. 
Published: February 2007

AbstractTwo case reports of extracardiac rhabdomyoma (adult type) are presented. The rare occurence of extracardiac rhabdomyoma and its relatively benign nature makes a histological diagnosis very necessary, though often difficult to make. In both cases reported here, a diagnosis of extracardiac rhabdomyoma was given and treatment with local excision yielded good results.The importance of a histological diagnosis and treatment by only a local excision is stressed.
Effects of administration routes on the uptake of uridine and 5‐fluorouridine into an adenocarcinoma transplanted to rat liver
Authors: Erichsen Christian , Christenson Per‐Inge , Eriksson Göran , Yngner Torsten , Jönsson Per‐Ebbe , Stenram Unne 
Published: February 2007

AbstractIn a model of secondary liver cancer in Wistar rats, the effect of different administration routes on the uptake of 3H‐uridine into tumor and several normal tissues was studied. The rats were inoculated with a tumor cell suspension in the central liver lobe. Ten days later, they were distributed into four groups with a catheter placed in the gastroduodenal artery, the portal vein, one of the femoral veins, or in the peritoneal cavity. 3H‐uridine was injected 46 h later and after an additional 90 minutes the animals were anesthezised and pieces of liver tumor and normal tissues were removed and frozen. The incorporation into the acid‐soluble fraction and RNA was analyzed. In a separate experiment, 3H‐fluorouridine was administered by the gastroduodenal artery and a comparison was made with the uptake of 3H‐uridine. A significantly higher amount of uridine was incorporated into the tumor by me arterial route. The intraportal and intraperitoneal routes were comparable, while a somewhat higher incorporation was found by the systemic route. The consequences of using the different routes upon the incorporation into RNA of tumor and dose‐limiting organs are demonstrated. With the aid of this experimental model, it is possible to evaluate further the effect by different manipulations on different drugs regarding the administration route.
Limitation of immunohistochemical localization of estrogen receptor
Authors: Chaudhuri Prabir K. , Chaudhuri Bina , Beattie Craig W. , Bigham Beatrice Z. , Das Gupta Tapas K. 
Published: February 2007

AbstractAlthough the radioreceptor method is widely used for estrogen receptor assay in human tissue, it has several limitations and a number of alternative methods are being explored. An immunohistochemical method of estrogen receptor assay using a specific antibody to estradiol has been proposed as a suitable alternative. The present study was designed to evaluate the validity of this method in detecting true estrogen receptors in human tumor tissue. Using radioiodinated antibody to estrogen, we have demonstrated that the estrogen antibody can detect the estrogen when it is bound to 4S type receptor but is unable to bind to estrogen when the hormone is bound to 8S type receptor. Our observations suggest that the immunohistochemical method of detection of intracellular cytosolic receptor for estrogen is not a suitable alternative to the currently used radioreceptor method.
Threatened carotid artery rupture: A complication of radical neck surgery
Authors: Sanders Elissa M. , Davis Kenneth R. , Whelan Charles S. , Deckers Peter J. 
Published: February 2007

AbstractCarotid artery rapture is an infrequent but highly dangerous postoperative complication of radical head and neck surgery. The principal predisposing factors are radiation therapy, infection, tissue necrosis, vessel exposure, and pharyngeal fistula formation. Actual or threatened carotid artery rupture has been most commonly managed by ligation of the involved vessel. We present a patient who showed signs of impending carotid artery rupture after both irradiation and radical neck surgery. Balloon embolization was employed in preference to traditional carotid artery ligation. The patient's risk factors for carotid artery rupture are analyzed and the application of balloon embolization is discussed.
Distant metastases of nasopharyngeal carcinoma: A study of 256 male patients
Authors: Ahmad Anwar , Stefani Stefano 
Published: February 2007

AbstractThe records of 256 patients with nasopharyngeal carcinoma have been reviewed to determine the incidence and location of distant metastases, Sixty‐three patients underwent autopsy. The incidence of distant metastases was 36% overall, and 51% in the autopsy patients. Bones, distant lymphnodes, liver, and lungs were the most common sites of distant metastases. Liver was the most common site in the autopsy patients. Compared to other major histological subtypes, undifferentiated carcinoma had the highest incidence of bone but lowest incidence of lung metastases. There was a strong correlation between advanced locoregional disease and distant metastases. Of those patients who developed distant metastases, 98% were discovered within 3 years or earlier. Thorough evaluation of the above organs/systems is indicated at the time of initial staging work‐up and at follow‐up, specifically for patients with advanced locoregional disease. A literature review of distant metastases in nasopharyngeal carcinoma is presented.
Good tolerance to high‐dose hepatic arterial infusion therapy
Authors: Wile Alan G. , Kasimis Basil S. , Iyer Padmini , Kaneshiro Claudia A. , Moran Edgar M. 
Published: February 2007

AbstractA pilot study was designed to evaluate the efficacy of high‐dose FUDR administered through the hepatic artery for the treatment of cancer involving the liver. Three dose schedules were used beginning with a dose of 0.5 mg FUDR/kg/day for 2 weeks followed by normal saline infusion for 2 weeks (schedule A). Elevation of serum bilirubin was the sole indication to deescalate to schedule B (0.3 mg FUDR/kg/day for two weeks followed by saline‐infusion for 4 weeks). Tolerance to this schedule escalated the patient to schedule C (0.5 mg FUDR/kg/day for 2 weeks followed by normal saline infusion for 4 weeks). Eighteen patients were treated, sixteen with metastatic colon cancer, one with metastatic leiomyosarcoma, and one with hepatoma. The patient with hepatoma developed progressive disease after one cycle of therapy. Of the 17 patients with metastatic cancer only 5 patients failed therapy yielding a 70% response rate. High‐dose FUDR was well tolerated with only six patients requiring deescalation to schedule B. Elevation of alkaline phosphatase and glutamic oxaloacetic transaminase was universal. Two patients developed peptic ulceration. Sclerosing cholangitis was not observed. We conclude that high‐dose FUDR administered through the hepatic artery is as safe as conventional dose infusion therapy but probably not more effective. The safety of high‐dose FUDR infusion therapy suggests that sclerosing cholangitis is association with hepatic arterial infusion therapy is not related to the FUDR dose.
Recurrent olfactory neuroblastoma treated by radiation, surgery, and chemotherapy: “A case report”
Authors: Mohanti B. K. , Rath G. K. , Baser B. , Bahadur S. , Mathur M. 
Published: February 2007

AbstractOlfactory neuroblastoma is a rare tumor. The role of CT Scan, morphological details and the electron microscopic findings have been highlighted in the diagnosis of the lesion. The present patient, in which the tumor had recurred following surgical excision, was treated successfully with a combination of radiation, further surgery, and maintenance chemotherapy. We also feel that such a planned multidisciplinary approach is justified as the initial treatment for all advanced lesions in view of high recurrence rates reported following use of radiotherapy or surgery alone.
Renal cell carcinoma in a patient with situs inversus totalis
Authors: Bertini John E. , Boileau Michel A. 
Published: February 2007

AbstractSitus inversus occurs with a frequency of about 1 in 8,000. We present a case of renal cell carcinoma in a patient with situs inversus totalis treated with nephrectomy. Uneventful operative management was attained by adequate preoperative radiologic evaluation.
Mucoepidermoid carcinoma of the stomach
Authors: Hayashi Itsuro , Muto Yukiro , Fujii Yoshio , Morimatsu Minoru 
Published: February 2007

AbstractA rare case of mucoepidermoid carcinoma of the stomach in a 70‐year‐old man is reported. The protruded mass with central depression resembled a submucosal tumor, located on the posterior wall of a part of the cardia, fornix, and upper corpus. Histologically, submucosal ectopic glands composed of columnar cells, mucus‐producing cells that closely resemble gastric epithelium, and ciliated epithelium were observed. The tumor consisted of an admixture of cuboidal, columnar cells, mucus‐producing cells, singled or pseudostratified ciliated epithelium, and squamous metaplastic cells. The tumor cells were intimately continuous with the submucosal ectopic glands. Gradual transition between tumor cells and epithelium of submucosal ectopic glands was recognized. It is supposed that mucoepidermoid carcinoma of the stomach in this case derived from preexisting submucosal ectopic mucous glands of the stomach.
Secondary urinoma mimicking recurrent tumor as a cause of bilateral ureteral obstruction
Authors: Zein Tawfik A. , Huben Robert P. , Petrelli Nicholas J. , Reid Stephen , Pontes J. Edson 
Published: February 2007

AbstractA case is reported of a previously resected adenocarcinoma of the rectum presenting with recurrent tumor in the pelvis and an abdominal mass that was found to be a large urinoma. Dialysis was discontinued after drainage of the extravasated urine, and the patient's condition became stable. A review of the literature is also discussed.
Hepatocellular carcinoma causing obstructive jaundice
Authors: Sarma Deba P. , Weilbaecher Thomas G. , Deipairine Erico M. 
Published: February 2007

AbstractA 67‐year‐old man presented with signs and symptoms of obstructive jaundice. At autopsy, a hepatocellular carcinoma was noted to have obstructed both hepatic ducts and the common hepatic duct. Literature is reviewed to elaborate on this unusual manifestation of hepatocellular carcinoma.
An evaluation of routine follow‐up for detection of breast cancer recurrences
Authors: Zwaveling A. , Albers G. H. R. , Felthuis W. , Hermans J. 
Published: February 2007

AbstractFour hundred patients who were radically treated for breast carcinoma during the period May 1974 to December 1980 were followed for a minimum of 4 years. The outcomes of the 128 patients with recurrences were studied. A differentiation into two groups was made: those in whom recurrences were detected as a real result of follow‐up (27%) and those in whom this was not the case (73%). Both groups were comparable as regards age, period “at risk,” nature and site of recurrence, type of therapy instituted, and their response to it. No differences could be found in any of these factors. The recurrence‐free interval, the survival after institution of therapy, and the total survival after the primary procedure were the same in both groups.
Metastatic colon carcinoma to the jaw: A case report and review of the literature
Authors: Mast Harold L. , Nissenblatt Michael J. 
Published: February 2007

AbstractPresented is a case of adenocarcinoma of the cecura metastatic to the anterior mandible. The patient had a Duke's C2 cecal adenocarcinoma resected twenty months prior to her development of loose teeth, jaw pain, and jaw mass. A biopsy of the mass revealed metastatic adenocarcinoma, identical to her primary neoplasm. Metastatic carcinoma to the mandible is a rare event. A review of the literature reveals only nineteen cases of colon carcinoma metastatic to the jaw. When further subdivided, there is only one other case of cecal adenocarcinoma metastasizing to the jaw. Almost half of the other cases have been rectal carcinomas. Treatment of these patients has been uniformly unsuccessful, with life expectancy reported between one and seven months. The literature has shown that 5‐FU and radiotherapy may produce palliation of symptoms. The patient presented here responded well to 5‐FU and radiotherapy.
Early metastatic patterns and survival in malignant melanoma
Authors: Nambisan Raman N. , Alexiou George , Reese Peter A. , Karakousis Constantine P. 
Published: February 2007

AbstractTwo hundred fifty patients with distant metastasis from malignant melanoma were analyzed at the first appearance of systemic metastasis. Commonly involved sites were lung, subcutaneous tissue, brain, and liver. Frequency of liver metastasis was higher with eye and mucous membrane primary sites (P < 0.01). Liver involvement had the worse survival compared to lung and brain. Patients with mucosal or unknown primary sites had decreased survival compared to other sites (P < 0.01). Patients with primary melanomas thicker than 4 mm had significantly shorter survival (P < 0.02). Single‐organ involvement correlated with ionger survival compared to multiple‐organ involvement (P < 0.04). Survival of metastatic disease was more favorable in patients with involvement of subcutaneous tissue only and in those with a disease‐free interval of 2 years or longer. Five‐year survival from first appearance of metastasis was 7% and median survival was 8 months.