bluuebunny/crossref_metadata_2025_split huggingface dataset:
Refining the Make My Day stroke prevention intervention for primary healthcare through co-creation with stakeholders
Authors: Johnsson Cecilia , Jakobsson Elin , Hagströmer Maria , Guidetti Susanne , Patomella Ann-Helen , Asaba Eric 
Published: February 2025

Abstract

Objectives
To describe and explore the refinement of a stroke prevention intervention and conditions for implementation in primary healthcare by utilising co-creation with stakeholders.

Method
This was an iterative co-creation process of five collaborative workshops engaging stakeholders; healthcare professionals (HP), and persons at risk for stroke, who participated in or delivered a stroke prevention intervention in primary healthcare.

Results
Through co-creation with stakeholders key components for revision were identified in the Make My Day intervention. The overall pedagogics, which was recognised as overarching, and three additional key components: the HP education, the intervention sessions, and the digital tool were identified. Moreover, the co-creation process rendered refinements of the prevention program addressing the key components representing stakeholder experiences. Refinements encompass delivering and receiving the Make My Day intervention, material ownership, and the interprofessional team.

Conclusions
The co-creation process revealed the importance of applying a strategic pedagogic approach in a complex intervention. The process underscored the need to augment a sense of material ownership and to improve interprofessional collaboration in primary healthcare, ultimately enhancing the intervention experience and facilitating the change process for individuals at risk of stroke. Utelising a co-creation process in this current intervention allowed for creation of refinements to the intervention optimising conditions for implementation.
A rare case of brain hemorrhage secondary to venous angioma in the right parietal lobe: case report and literature review
Authors: Altamirano Juan Manuel , Salinas-Barboza Karla , Lopez-Ortiz Eduardo , Fernandez-Gutiérrez Luis Miguel Alfonso 
Published: February 2025

Abstract

Background
Venous angiomas, also known as developmental venous anomalies (DVAs), are congenital vascular malformations that typically do not cause neurological symptoms. However, in rare cases, they can present with headaches, seizures, and even hemorrhages. This report highlights a rare case of a brain hemorrhage secondary to a venous angioma in the right parietal lobe without the common association with a cavernoma.

Case presentation
A 41-year-old woman experienced a sudden and severe headache, dizziness, left-sided hemihypoesthesia followed by seizures. Initial brain CT scans and MRI revealed a right parietal lobe bleed with a nodular hyperintense lesion on T1 and T2 sequences with lobulated borders and a hemosiderin halo on gradient echo sequences, initially suspected to be a cavernoma. Subsequently, the lesion was surgically resected using neuronavigation. The neuropathologic evaluation confirmed a venous angioma. Postoperatively, the patient was managed with antiepileptic medication and remained with left-sided hemihypoesthesia. Follow-up imaging showed stable residual gliosis and no active vascular anomalies.

Conclusions
This case underscores the importance of thorough pathological assessment and advanced imaging in accurately diagnosing DVAs. While typically benign, DVAs can present significant clinical challenges when symptomatic. This case is particularly notable for the absence of an associated cavernoma, which is more commonly seen and often responsible for hemorrhagic presentations.
Metabolites induced by citrus tristeza virus and ‘Candidatus Liberibacter asiaticus’ influence the feeding behavior of Diaphorina citri: an electrical penetration graph and LC–MS/MS study
Authors: Zhang Jingtian , Xia Fengchun , Li Yuhe , Liu Yangyang , Wu Fengnian , Deng Xiaoling , Xu Meirong 
Published: February 2025

Abstract
Citrus Huanglongbing and Citrus tristeza are two diseases that affect the citrus industry worldwide. The pathogens causing these diseases are the phloem-limited bacteria ‘Candidatus Liberibacter spp.’ (mainly Ca. L. asiaticus, CLas) and citrus tristeza virus (CTV). We recently found that both CLas and CTV could be acquired and retained by the Asian citrus psyllid Diaphorina citri. However, the mechanism through which CLas and CTV interact with the insect vectors and plant hosts has not been defined. In this study, an electrical penetration graph was used to study the feeding behavior of D. citri adults on four groups of Citrus reticulata Blanco cv. Hongjü plants: healthy, CLas-infected, CTV-infected, and CTV-CLas coinfected plants. Liquid chromatography with tandem mass spectrometry (LC–MS/MS) was applied to analyze the metabolites of the four groups of plants. The combined results are as follows: (1) The lowest number of metabolites were enriched in CTV-infected plants, which hardly influenced the feeding behavior of D. citri, suggesting that mild CTV strain (CT31) infection caused limited disorders in citrus plants compared with CLas infection; (2) Increased levels of L-arabinose and kaempferol in CTV-infected and CLas-CTV coinfected plants were suggested to contribute to increased penetration time during feeding of D. citri. CLas-infection increases the difficulty of finding appropriate feeding sites by the vector and results in xylem feeding for certain duration; (3) A significant reduction in α-linolenic acid metabolism in CLas-infected plants was found to be related to methyl jasmonate signaling, which induced resistance to D. citri and increased the duration of salivation. This effect was reversed by coinfection with CTV and was consistent with the phloem structure and carbohydrate accumulation alteration; (4) Stress response-associated 2'-hydroxygenistein and sakuranetin were highly upregulated flavonoid in CTV-CLas coinfected plants. This combinged with the anatomical alterations might interfere with D. citri feeding in the citrus phloem, as reflected by the time reduction of sap-sucking there. These findings will provide new insights into the interactions between CTV and CLas in citrus and the insect vector D. citri that transmiting these pathogens.
Outcomes of total hip replacement in adults with septic arthritis of the native hip joint: A systematic review
Authors: Cheong Teddy , Selvakumar Surya Varma , Goh Ryan Kwang Jin , Moo Ing How 
Published: February 2025

Abstract

Background
Septic arthritis is a debilitating condition that results in joint destruction and irreversible loss of joint function. Surgical treatment options include arthroscopy, resection arthroplasty, and total hip replacement (THR). Current literature on the treatment of septic arthritis of various joints includes periprosthetic or native joints. However, to our knowledge, a consolidated review that focuses solely on THR outcomes in a previously infected native hip is still lacking. This systematic review, for the first time, examined the clinical outcomes of THR, specifically in adults with septic arthritis of the native hip joint.

Methods
PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), SCOPUS, Cochrane Library, grey literature, and bibliographic references were searched from inception to October 2023. Only case series or cohort studies published within the last 20 years assessing the outcomes of THR for native hip septic arthritis were included. Literature retrieval and data extraction were conducted by three independent reviewers. Re-infection rate and various functional outcomes, measured in terms of the Harris Hip Score (HHS), Visual Analogue Scale (VAS), Merle D'Aubigne and Postel (MAP), Western Ontario, McMaster Universities Arthritis Index (WOMAC) Short Form 12-Item (SF-12) scores, were analyzed. Range of motion (ROM) and limb length discrepancy (LLD) were also examined.

Results
Against the relevant criteria, seven studies (six case series, one cohort study) involving 1243 patients were included. The patients aged from 18 to 78 years old. The reinfection rate ranged from 0 to 22.8%, with a mean rate of 19.6%. With regards to functional outcomes, the mean increase in HHS was from 39.5 to 48.92 and the increase in MAP ranged from 7.3 to 10.9. Improvement in LLD ranged from 2.28 to 3.52 cm, with all studies reporting < 1 cm of LLD postoperatively.

Conclusion
THR, both single and two-staged, is an effective treatment option for septic arthritis of the native hip joint that and yields good functional outcomes and acceptable reinfection rates. However, more prospective and randomized trials are needed to establish clear protocols on antibiotic regimes, clinical criteria clearance, and optimal time from infection to joint replacement.
Artificial intelligence v/s human intelligence: a relationship between digitalization and international trade
Authors: Aggarwal Vani , Karwasra Nidhi 
Published: February 2025

Abstract

Purpose
The influence of artificial intelligence (AI) on society has become a hot topic of discussion as it is being incorporated into academics and other fields. With the growing adoption of AI, this article focuses on a critical comparison between AI-driven insights and human intelligence in understanding complex issues. Specifically, it explores whether AI alone can effectively shape research agendas on the intersection of digitalization and international trade, or if human expertise remains indispensable.

Design/methodology/approach
This study employs a comparative framework, comparing AI-generated insights on digitalization and international trade (via ChatGPT) with key perspectives derived from a comprehensive review of human-generated academic literature.

Findings
The findings reveal that while AI can significantly enhance research efficiency and streamline access to information, it falls short of fully replacing human intelligence. AI proves inadequate in delivering in-depth and comprehensive evaluations, particularly in complex fields like the interplay between digitalization and international trade. The analysis underscores that while human intelligence remains sufficient for conducting rigorous research, AI serves as an efficient but ultimately insufficient tool for fully analysing the intricate dynamics of digitalization and trade.

Originality
This study uniquely investigates the comparative strengths and weaknesses of AI-generated versus human-generated insights, to evaluate the relationship between digitalization and international trade.
Sungai Batu Archaeological Complex (SBAC) in Kedah, Malaysia, as a sustainable heritage tourism product
Authors: Halim Mohd Hasfarisham Abd , Masnan Shyeh Sahibul Karamah , Saidin Mokhtar 
Published: February 2025

Abstract
Archaeological research at the Sungai Batu Archaeological Complex (SBAC) has revealed evidence of iron smelting workshops, river jetties, port management buildings, and ritual and Buddhist sites across an area of 4 km2. These features were developed into a heritage tourism product in the Kuala Muda district. To support heritage tourism, the data collected through field studies were processed into a 3-dimensional form via CorelDraw X7 (64-bit) and 3ds Max software. The Living Culture Gallery at the SBAC develops heritage tourism by applying digital technology such as VR, AR, hologram fans, and QR codes. Therefore, it directly contributes to the promotion of tourist sites and ensures their sustainability.
Impact of Funding Source on Long-Term Outcomes in Prostate Cancer: Analysis of a Large Public Database From Sao Paulo, Brazil
Authors: Maluf Fernando C. , de Oliveira Cintia S.K.S. , Ziegelmann Patrícia K. 
Published: February 2025

PURPOSE

We investigated the impact of the funding source (public
v
private) on the overall survival (OS) of men with prostate cancer in Brazil.

METHODS
We retrospectively analyzed patients with prostate cancer from a large hospital registry from the state of São Paulo, Brazil. Patients age 50-99 years diagnosed with prostate acinar adenocarcinoma or adenocarcinoma not otherwise specified (NOS) between January 2014 and December 2017 were eligible. Demographic and clinical features were analyzed alongside the funding source. On the basis of clinical characteristics at diagnosis (lymph node status, distant metastasis, prostate-specific antigen [PSA], and Gleason score), patients were categorized into low-risk, intermediate-risk, high-risk, and metastatic groups.

RESULTS

Of 25,009 patients analyzed, 85% had a public funding source. These patients were slightly older, had greater proportion of adenocarcinoma NOS, and higher PSA levels and risk category. There was a significant difference in OS favoring patients with a private funding source (
P
< .0001). The estimated OS rates at 5 years were 76.2% (95% CI, 75.6 to 76.9) and 86.9% (95% CI, 85 to 88.7) for the public and private groups, respectively (
P
< .0001). The funding source was significantly associated with OS independent of age, educational level, and receipt of any treatment in the intermediate-risk (hazard ratio [HR], 2.28 [95% CI, 1.58 to 3.30];
P
< .001) and high-risk (HR, 1.36 [95% CI, 1.02 to 1.80];
P
= .04) groups, but not in the low-risk (HR, 0.85 [95% CI, 0.60 to 1.21];
P
= .38) or metastatic groups (HR, 0.84 [95% CI, 0.64 to 1.11];
P
= .23).

CONCLUSION
The worse OS observed for patients with prostate cancer with a public source of funding underscores the need for actions directed to improve the standards of public health care in Brazil.
Addressing the Oncologist Shortage in Latin America: Insights From a Survey of Medical Oncology Fellowship Programs
Authors: Zegarra-López Mauricio , Aranda-Gutierrez Alejandro , Muñoz Lozano Jose Felipe , Villarreal-Garza Cynthia 
Published: February 2025

PURPOSE
Limited information exists about medical oncology fellowship programs in Latin America. Our study aimed to clarify unknowns, with the goal of identifying areas for improvement and potential expansion of fellowships.

MATERIALS AND METHODS
Sixteen medical oncologists, each from a different Latin American country, were surveyed using an online questionnaire. Descriptive statistics were used to summarize the collected variables.

RESULTS
In total, 232 fellowship programs exist in the surveyed nations, of which 444 medical oncologists graduate every year. Only Argentina, Brazil, Chile, Mexico, and Peru have more than five active fellowship programs. Honduras and Nicaragua did not report any fellowship programs. These nations—along with Colombia, Ecuador, El Salvador, Guatemala, and Peru—depend on foreign education for the training of their medical oncologists. Only one of every 50 medical graduates pursues a career path in medical oncology, and a mere 2.2% of internal medicine residents transition into the field. Nearly half of the data were collected through word of mouth, as many countries lack official, publicly accessible sources for some of the variables studied.

CONCLUSION
This study serves as a pioneering effort that future research groups can build upon. We believe that addressing the shortage of medical oncologists in Latin America by increasing the number of locally trained fellows is the most effective way to swiftly and sustainably improve cancer outcomes.
Financial Distress Screening and Navigation in Pediatric Oncology Within the National Cancer Institute Community Oncology Research Program
Authors: Robles Joanna M. , Dressler Emily V. , Kittel Carol , Nightingale Chandylen L. , Kyono Wade T. , Santacroce Sheila J. , Salsman John M. , Montez Kimberly , Prasad Pinki , Sugalski Aaron J. , Ohlsen Timothy J.D. , Zheng Daniel J. , Parsons Susan K. , Beauchemin Melissa P. 
Published: February 2025

PURPOSE
Cancer-related financial hardship is associated with poor quality of life, risk of household material hardship, and psychological distress for families affected by pediatric cancer. Current processes on financial distress screening and financial navigation across the pediatric National Cancer Institute Community Oncology Research Program (NCORP) network remain unknown.

METHODS
Financial distress screening and financial navigation services among NCORP practices were assessed using two survey items from the 2022 NCORP Landscape Assessment Survey. Practices answering yes to providing oncology care for pediatric patients were included. Univariable models were used to test associations between practice characteristics and financial screening and financial navigation.

RESULTS

Of the 53 NCORP practices serving pediatric patients with cancer that responded to the survey, 44 (83%) reported routinely conducting financial distress screening. Most of the practices reported that financial screening is completed by social workers (n = 40/44, 91%). One third of practices reported financial screening using a survey completed by patients/caregivers (n = 14/44, 32%). Almost all practices (n = 51/53, 96%) reported responding to financial needs through a social worker. One third of the practices reported having a cancer-specific financial navigator (n = 17/53, 32%) or a nondedicated (not cancer-specific) financial navigator (n = 19/53, 36%). Practices that served a proportion of new patients with cancer at or above the national average of Hispanic individuals in the United States were as likely to screen for financial distress as practices below the national average (odds ratio, 2.42 [95% CI, 0.45 to 13.03];
P
= .30).

CONCLUSION
Most pediatric NCORP practices report screening for financial distress. Fewer groups offer dedicated cancer-specific financial navigation, and practices vary. Further research is needed to explore the development and implementation of standardized financial distress measures and financial navigation interventions within pediatric cancer care.
Phase II Study of Copanlisib in Patients With PTEN Loss: Results From NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocols Z1G and Z1H
Authors: Gouda Mohamed A. , Wei Zihan , Rodon Jordi , Davies Michael A. , Janku Filip , Gray Robert J. , Wang Victoria , McShane Lisa M. , Rubinstein Larry V. , Patton David R. , Williams P. Mickey , Hamilton Stanley R. , Liu Raymond , Bota Daniela A. , Swiecicki Paul L. , Buchschacher Gary L. , Tricoli James V. , Conley Barbara A. , Arteaga Carlos L. , Harris Lyndsay N. , O'Dwyer Peter J. , Chen Alice P. , Flaherty Keith T. 
Published: February 2025

PURPOSE
Copanlisib, a pan-class phosphatidylinositol 3-kinase (PI3K) inhibitor with activity predominantly against the PI3K-delta and PI3K-alpha isoforms, has shown promising results in preclinical cancer models with PTEN loss. Herein, we report the activity and safety data from the Z1G and Z1H subprotocols, which included patients with PTEN loss, of the National Cancer Institute Molecular Analysis for Therapy Choice trial.

METHODS

Patients with complete loss of cytoplasmic and nuclear PTEN as determined by immunohistochemistry regardless of
PTEN
mutation or deletion status were included in subprotocol Z1G, and patients with a deleterious mutation in the
PTEN
gene and retained expression of PTEN were included in subprotocol Z1H. Copanlisib was given intravenously over 1 hour at a dose of 60 mg on days 1, 8, and 15 in a 21-day-on and 7-day-off schedule in 28-day cycles. Patients continued treatment until disease progression or unacceptable toxicity.

RESULTS
Overall, 49 patients (20 patients in Z1G and 29 in Z1H) were included in the primary efficacy analyses. The objective response rates in both cohorts were 0% (Z1G; 90% CI, 0 to 13.9) and 3.4% (Z1H; 90% CI, 0.2 to 15.3), respectively. The median progression-free and overall survival durations were 1.8 months (90% CI, 1.4 to 3.9 months) and 13.7 months (90% CI, 6.8 to 18.3 months) for the Z1G cohort and 1.8 months (90% CI, 1.8 to 2.1 months) and 9.0 months (90% CI, 5.4 to 13.3 months) for the Z1H cohort, respectively.

CONCLUSION

Our results do not support the antitumor activity of single-agent copanlisib in tumors with PTEN loss regardless of mutation or deletion status or
PTEN
deleterious mutations with PTEN expression.
On the Mental Health Commons
Authors: Minozzo Ana , Soreanu Raluca 
Published: February 2025

Abstract
The political history of psychoanalysis is marked by a tension between a widely critiqued reproduction of alienation and the capacity to open radical spaces for rethinking subjectivity and practicing togetherness. This essay's research focuses on moments when fugitive free clinics are formed, functioning in friction with the psychoanalytic establishment, and centered on deindividualizing and commoning practices in the clinical realm. In this essay, the authors follow free clinics in Brazil, from the 1970s to the present. These are marginal, open-border clinics. Developing a vocabulary to account for what the authors call “the mental health commons,” they attend to scenes of fugitivity, to territorial listening, and to a creative “corruption” of psychoanalysis and its mainstream practices. Ultimately, what emerges is a set of autonomous, emancipatory free clinics, where creativity and the imagination are potent, and social symptoms turn into affective bonds, commonly unleashed.
Standing with Myanmar
Authors: Kim Hieyoon 
Published: February 2025

Abstract
Since the military coup in Myanmar on February 1, 2021, South Korean artists and exhibit makers have tapped into the power of art activism to support the Burmese struggle for democracy. This essay pays special attention to two of the earliest exhibitions held in Gwangju, a southwestern hub in the peninsula that since May 1980 has been widely been known as a site of civil resistance. With a focus on each show's narrative and audience engagement in relation to the historic meaning of Gwangju, this essay considers the limits of transnational solidarity imagined through art activism, revealing solidarities that reinforce either the nation-state as primary in defining political subjectivity or the universalist humanism at their core. Although these shows allow the empathic positioning of artists to a certain degree, their activism does not necessarily provide meaningful means of building south-south partnership.
Notch3 deletion regulates HIV-1 gene expression and systemic inflammation to ameliorate chronic kidney disease
Authors: Thornton Mackenzie , Sommer Nicole , McGonigle Mercedes , Kumar Ram Anil , Yerrathota Sireesha , Ehirim Henrietta , Chaturvedi Aakriti , Dinh Phan Johnny , Chakraborty Anubhav , Chakravarthi V. Praveen , Gunewardena Sumedha , Tyagi Mudit , Talreja Jaya , Wang Tao , Singhal Pravin , Tran Pamela V. , Fields Timothy A. , Ray Patricio E. , Dhillon Navneet K. , Sharma Madhulika 
Published: February 2025

ABSTRACT
Anti-retroviral therapy (ART) has decreased human immunodeficiency virus (HIV)-1-associated morbidity. However, despite ART, immune cells remain latently infected, leading to chronic inflammation and HIV-1-associated comorbidities. New strategies are needed to target viral proteins and inflammation. We found activation of Notch3 in renal cells of the HIV-1 transgenic mouse model (HIV-Tg26) and in patients with HIV-associated nephropathy. We hypothesized that targeting NOTCH3 activation constitutes an effective therapy for HIV-related chronic kidney disease. We generated HIV-Tg26 mice with Notch3 knocked out (Tg-N3KO). Compared to HIV-Tg26 mice at 3 months, Tg-N3KO mice showed a marked reduction in renal injury, skin lesions and mortality rate. They also showed reduced renal infiltrating cells and significantly reduced expression of HIV genes. Moreover, Notch3 activated the HIV long terminal repeat promoter, and induction of HIV-1 increased Notch3 activation, indicating a feedback mechanism. Further, bone marrow-derived macrophages from HIV-Tg26 mice showed activation of Notch3, indicating systemic effects. Consistent with that observation, systemic levels of TNF and MCP-1 were reduced in Tg-N3KO compared to HIV-Tg26 mice. Thus, Notch3 deletion/inhibition has a dual-therapeutic effect in HIV-related chronic kidney disease, which might extend to other HIV-related pathologies.