bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytical assessment of the osteoinductive material COLLOSS®E
Authors: Nienhuijs M. E. L. , Poulsen K. , van der Zande M. , Briest A. , Merkx M. A. W. , Stoelinga P. J. W. , Jensen O. N. , Jansen J. A. , Walboomers X. F. 
Published: September 2008

AbstractIn this study, the growth factors in COLLOSS®E were analyzed, using ELISA tests, mass spectrometry, western blotting, and a 24‐day cell culture experiment using osteoblast‐like cells. The results of the ELISA testing, mass spectrometry, and western blotting all confirmed that TGF‐β1 was the main growth factor in COLLOSS®E at 55 ng/mg. The results from the culture test showed that the cell proliferation, alkaline phosphatase activity, and matrix calcification were all drastically changed by the addition of COLLOSS®E, mirroring the effects of addition of TGF‐β1. We conclude that COLLOSS®E is not only a rich source of TGFβ‐1, but also contains the growth factors TGFβ‐2, BMP‐2, BMP‐3, BMP‐7, IGF‐1, and possibly VEGF. Other growth factors might be present in COLLOSS®E, but were not identified due to inherent detection limits of the used ELISA and mass spectrometry techniques. The number of osteoinductive factors in COLLOSS®E causes a synergistic effect, explaining the new bone formation found in previously described in vivo studies, with much lower growth factor concentrations when compared with recombinant BMPs. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
Properties of antibiotic‐loaded acrylic bone cements for use in cemented arthroplasties: A state‐of‐the‐art review
Authors: Lewis Gladius 
Published: September 2008

AbstractInfection of periprosthetic sites of total joint replacements has been widely reported. Although, by most accounts, the incidence of such events is low, the problem can prove to be expensive to remedy. In the case of cemented arthroplasties, a common management modality is the use of antibiotic‐loaded acrylic bone cement (ALABC) as a prophylaxis or a therapeutic agent. Although there is a large literature on properties of ALABCs (on the order of 100 journal articles), a comprehensive review is lacking. The present contribution, whose objective is to fill this gap, is organized in four parts. Details of the background to and motivation for the work are given in the first part, explicative summaries of literature studies on the influence of various factors on an array of in vitro and in vivo properties of ALABCs are covered in the second part, issues and areas for future studies are presented in the third part, and the fourth part contains a summary of the most salient points made in the review. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
In‐situ sol‐gel synthesis and characterization of bioactive pHEMA/SiO2 blend hybrids
Authors: Silvestri B. , Luciani G. , Costantini A. , Tescione F. , Branda F. , Pezzella A. 
Published: September 2008

AbstractA novel procedure to synthesize poly(2‐hydroxyethylmethacrylate)‐silica blend hybrids is presented. Methacrylate monomers bearing an alkoxysilyl unit, prepared by Michael addition of 2‐hydroxyethylmethacrylate (HEMA) to 3‐Aminopropyltriethoxysilane (APTS) were employed. By 13C NMR and mass analysis it was possible to establish the formation of coupling hybrid species. Hybrid materials, with final concentration ranging from 10% to 30% w/w of silica gel to the mass of polymer, were obtained through basic catalyzed sol‐gel process of tetraethoxysilane (TEOS) and the alkoxysilyl unit of the hybrid monomer, followed by in‐situ free‐radical polymerization. The hybrids were characterized as far as concerns their thermal properties (glass transition temperature, decomposition temperature), their sorption behavior in water, and in‐vitro bioactivity. Optical transparency, higher glass transition temperature, and higher decomposition temperature than pHEMA suggest an increase in either density or intensity of cross‐links between the organic and the inorganic phases. The swelling ratio of the 30% hybrids is comparable to pHEMA, whereas it is lower for the other compositions. In‐vitro bioactivity of the hybrids, due to the inorganic phase, was ascertained. Soaking time required for apatite deposition on the samples surface decreases as the content of silica gel increases. Therefore, the obtained bioactive hybrids can be used to make bioactive scaffolds for bone engineering. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
Accurate prediction of thermodynamic properties of alkyl peroxides by combining density functional theory calculation with least‐square calibration
Authors: Liu Cun‐Xi , Li Ze‐Rong , Zhou Chong‐Wen , Li Xiang‐Yuan 
Published: September 2008

AbstractOwing to the significance in kinetic modeling of the oxidation and combustion mechanisms of hydrocarbons, a fast and relatively accurate method was developed for the prediction of ΔfH of alkyl peroxides. By this method, a raw ΔfH value was calculated from the optimized geometry and vibration frequencies at B3LYP/6‐31G(d,p) level and then an accurate ΔfH value was obtained by a least‐square procedure. The least‐square procedure is a six‐parameter linear equation and is validated by a leave‐one out technique, giving a cross‐validation squared correlation coefficient q2 of 0.97 and a squared correlation coefficient of 0.98 for the final model. Calculated results demonstrated that the least‐square calibration leads to a remarkable reduction of error and to the accurate ΔfH values within the chemical accuracy of 8 kJ mol−1 except (CH3)2CHCH2CH2CH2OOH which has an error of 8.69 kJ mol−1. Comparison of the results by CBS‐Q, CBS‐QB3, G2, and G3 revealed that B3LYP/6‐31G(d,p) in combination with a least‐square calibration is reliable in the accurate prediction of the standard enthalpies of formation for alkyl peroxides. Standard entropies at 298 K and heat capacities in the temperature range of 300–1500 K for alkyl peroxides were also calculated using the rigid rotor‐harmonic oscillator approximation. © 2008 Wiley Periodicals, Inc. J Comput Chem, 2009
Energetic analyses of chair and boat conformations of maleimide substituted cyclohexane derivatives
Authors: Remmert Sarah , Parish Carol 
Published: September 2008

AbstractAn analysis of the conformational preferences of two maleimide substituted cyclohexane derivatives proposed as scaffolds for HIV‐1 fusion inhibitors is presented. Hybrid Low Mode‐Monte Carlo (1:1) conformational searches using seven different force fields were performed in combination with the GBSA(water) solvent model. Low energy structures identified in this way were subjected to geometry optimization on the B3LYP/6‐31G** surface. Solvent effects were included in the quantum calculation using the self‐consistent reaction field model for water. Quantum results indicate that the 1,3,5‐maleimide functionalized 1,3,5‐methyl cyclohexane is more stable in the boat conformation, whereas 1,3,5‐maleimide functionalized cyclohexane adopts the expected chair conformation with equatorial arms. None of the force fields studied was able to predict the unexpected preference for the boat conformation of 1,3,5‐maleimide functionalized 1,3,5‐methyl cyclohexane. Comparison of low energy and experimental structures was also performed. © 2008 Wiley Periodicals, Inc. J Comput Chem, 2009
Comparison of prototypic cases of depressive personality disorder and dysthymic disorder
Authors: Sprock June , Fredendall Laura 
Published: September 2008

AbstractAlthough depressive personality disorder (DPD) was included in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM‐IV; American Psychiatric Association, 1994) appendix as a proposed category needing further research, there are concerns that it overlaps excessively with dysthymic disorder (DD). The purpose of this investigation was to identify the characteristic features of representative patients with DPD and patients with DD, and to determine whether they could be distinguished by their symptoms. Two matched samples of psychologists (n=57, n=48) identified a prototypic patient with DPD or DD, provided demographic and treatment information about the patient, and rated the patient's symptoms on a series of mood and personality disorder symptoms taken from the DSM‐IV and the literature. When composite descriptions were constructed using the highest rated symptoms, there was considerable overlap in symptoms of identified DPD and DD patients. The DSM‐IV research criteria for DPD provided the best description of the DPD patients; however, there was a high degree of correlation between DPD and DD criteria sets. There was also considerable comorbidity, with the majority of the patients in both groups meeting criteria for DPD and DD. However, there was a significant difference in comorbid diagnoses (and other differences in family history, outcome, and treatment history that failed to reach the more stringent level of statistical significance, i.e., p<.001) suggesting that there may be some important differences between DPD and DD. Nevertheless, the symptom ratings imply blurred boundaries between DPD and DD, suggesting the need for clearer differentiation between the two disorders or the need to adopt an alternative model of classification. © 2008 Wiley Periodicals, Inc. J Clin Psychol 64:1–25, 2008.
Microimaging FTIR of head and neck tumors. IV
Authors: Conti Carla , Ferraris Paolo , Garavaglia Maria , Giorgini Elisabetta , Rubini Corrado , Sabbatini Simona , Tosi Giorgio 
Published: September 2008

AbstractOn continuing our studies on head and neck neoplasia, specimens from salivary gland tumors have been explored by using infrared microimaging spectroscopy to discern healthy from neoplastic tissues. Samples with Warthin tumor, epithelial displasia, marginal B‐cell lymphoma, low‐grade adenocarcinoma, and adenoid cystic carcinoma pathologies have been investigated by using conventional light sources. Changes were monitored at the molecular level, probing spectral markers such as Amide I and II, phosphate, nucleic acids, and carbohydrates vibrational modes. In all cases, supervised and unsupervised spectral analyses resulted in satisfactory agreement with histopathological findings. Microsc. Res. Tech., 2009. © 2008 Wiley‐Liss, Inc.
MRT letter: Full‐tilt electron tomography with a piezo‐actuated rotary drive
Authors: Xu X.J. , Lockwood A. , Guan W. , Gay R. , Saghi Z. , Wang J.J. , Peng Y. , Inkson B.J. , Möbus G. 
Published: September 2008

AbstractPiezoelectric nanoactuation, which is rapidly becoming established as state‐of‐the‐art positioning control in transmission electron microscopy (TEM), is extended here to include a rotational degree of freedom. A piezoelectric goniometer with both translational and rotary drive action has been designed with high level of miniaturization to fit into a standard TEM specimen holder shaft without compromising any of the performance of the default TEM goniometer and without any modifications to the TEM. Enhanced functionality of such a goniometer‐in‐goniometer is outlined and experimental results for electron tomography of nanostructures over a full tilt range of views, without any missing angles, are demonstrated. Microsc. Res. Tech., 2008. © 2008 Wiley‐Liss, Inc.
Characterization of natural wax esters by MALDI‐TOF mass spectrometry
Authors: Vrkoslav Vladimír , Míková Radka , Cvačka Josef 
Published: September 2008

AbstractThe applicability of matrix‐assisted laser desorption/ionization time of flight mass spectrometry (MALDI‐TOF MS) to the analysis of wax esters (WEs) was investigated. A series of metal salts of 2,5‐dihydroxybenzoic acid (DHB) was synthesized and tested as possible matrices. Alkali metal (Li, Na, K, Rb, Cs) and transition metal (Cu, Ag) salts were studied. The matrix properties were evaluated, including solubility in organic solvents, threshold laser power that should be applied for successful desorption/ionization of WEs, the nature of the matrix ions and the mass range occupied by them, and the complexity of the isotope clusters for individual metals. Lithium salt of dihydroxybenzoic acid (LiDHB) performed the best and matrices with purified lithium isotopes (6LiDHB or 7LiDHB) were recommended for WEs. Three sample preparation procedures were compared: (1) mixing the sample and matrix in a glass vial and deposition of the mixture on a MALDI plate (Mix), (2) deposition of sample followed by deposition of matrix (Sa/Ma), and (3) deposition of matrix followed by deposition of sample (Ma/Sa). Morphology of the samples was studied by scanning electron microscopy. The best sample preparation technique was Ma/Sa with the optimum sample to matrix molar ratio 1 : 100. Detection limit was in the low picomolar range. The relative response of WEs decreased with their molecular weight, and minor differences between signals of saturated and monounsaturated WEs were observed. MALDI spectra of WEs showed molecular adducts with lithium [M + Li]+. Fragments observed in postsource decay (PSD) spectra were related to the acidic part of WEs [RCOOH + Li]+ and they were used for structure assignment. MALDI with LiDHB was used for several samples of natural origin, including insect and plant WEs. A good agreement with GC/MS data was achieved. Moreover, MALDI allowed higher WEs to be analyzed, up to 64 carbon atoms in Ginkgo biloba leaves extract. Copyright © 2008 John Wiley & Sons, Ltd.
Rapid determination of picogram levels of patulin in apple juice using a flow injection chemiluminescence procedure
Authors: Liu Houyong , Gao Xiaofei , Niu Lichuan , Li Xin , Song Zhenghua 
Published: September 2008

AbstractBACKGROUND: A sensitive, rapid and simple chemiluminescence procedure, based on the enhancing effect of patulin on the chemiluminescence (CL) reaction between luminol and hydrogen peroxide in a flow injection (FI) system, has been proposed for the determination of patulin.RESULT: The increment of CL intensity was linear over the concentration of patulin ranging from 0.05 to 80 ng mL−1, with a detection limit (3S/N) of 0.01 ng mL−1. At a flow rate of 2.0 mL min−1, a complete analysis could be performed in 25 s with a relative standard deviation of less than 4.0%.CONCLUSION: The proposed method was successfully applied to the measurement of apple juice samples obtained from the Shaanxi Entry–Exit Inspection and Quarantine Bureau. The recoveries were between 93.4 and 107.9% Copyright © 2008 Society of Chemical Industry
Analysis of the pour point of coconut oil as a lubricant base stock using differential scanning calorimetry
Authors: Ajithkumar G. , Jayadas N. H. , Bhasi M. 
Published: September 2008

AbstractOne of the major disadvantages of vegetable oils as base stock for lubricants is their high pour points. In this paper the crystallisation behaviour of coconut oil and the effect of additive addition and the chemical modification on its pour point were analysed using differential scanning calorimetry (DSC). Coconut oil showed the highest pour point among the vegetable oils considered in the study. This can be attributed to the predominantly saturated nature of its fatty acid constituents. Addition of additives did not show any significant improvement in the pour point of coconut oil. The chemical modification procedures described in this work have been effective in improving the pour point of coconut oil to some extent. The DSC method used in the present work has been found to be helpful in understanding the crystallisation behaviour of vegetable oils with different fatty acid compositions, the effect of additive addition and the chemical modification on pour point of coconut oil. Copyright © 2008 John Wiley & Sons, Ltd.
Effects of dopaminergic medications on psychosis and motor function in dementia with Lewy bodies
Authors: Goldman Jennifer G. , Goetz Christopher G. , Brandabur Melanie , Sanfilippo Michelle , Stebbins Glenn T. 
Published: September 2008

AbstractDopaminergic treatment in dementia with Lewy bodies (DLB) requires balancing risk of worsened psychosis and potential motor benefit. We assessed the effects of increased dopaminergic medication on psychosis and motor function in DLB. We studied 19 subjects fulfilling probable DLB Consensus criteria before and after increased dopaminergic medications. Standard clinical measures included: Thought Disorder score from the Unified Parkinson's disease Rating Scale (UPDRS) Part I, total motor score (UPDRS Part III), and Hoehn–Yahr (H&Y) stage. Motor benefit defined as >10% improvement over baseline UPDRS Part III score, occurred in only one‐third of subjects. In this group, worsened hallucinations or psychosis developed in one‐third. Considering motor benefit without exacerbation of psychosis as our aim, only 4 DLB subjects (22%) achieved this goal. Our results suggest that dopaminergic medications have limited benefit in DLB because of the low likelihood of motor improvement and the risk of psychosis exacerbation. © 2008 Movement Disorder Society
Essential tremor might be less frequent than Parkinson's disease in North Israel Arab villages
Authors: Glik Amir , Masarwa Magdalena , Abuful Amin , Deeb Amar , Strugatsky Rosa , Farrer Lindsay A. , Friedland Robert P. , Inzelberg Rivka 
Published: September 2008

AbstractEssential tremor (ET) is much more prevalent than Parkinson's disease (PD) in Western countries. We estimated ET and PD prevalence in Wadi Ara Arabic villages in Northern Israel. In this door‐to‐door survey, all consenting residents aged ≥65 years were systematically examined by an Arabic speaking team. No prescreening questionnaires were used. A random sample of 900 subjects [437 males, mean age (SD) = 72.6 years (6.6)] of the 2,163 eligible residents were evaluated. Sixteen subjects had an action, intentional tremor. Tremor prevalence was estimated as 1.78% (95% CI 1.1–2.87). Nine of these had another likely cause of tremor. Only 7 patients were diagnosed as ET [prevalence 0.78% (95% CI 0.38–1.6)]. PD was diagnosed in 13 subjects. PD prevalence was 1.44% (95% CI 0.84–2.45). ET is unusually uncommon in this population and possibly even less frequent than PD. The PD prevalence in Wadi Ara is similar to that reported in Western countries. © 2008 Movement Disorder Society
Effect of thalamotomy on focal hand dystonia in a family with DYT1 mutation
Authors: Kim Mi J. , Jeon Sang R. , Yoo Han‐Wook , Kim Gu‐Hwan , Lee Myoung C. , Chung Sun J. 
Published: September 2008

AbstractWe report the clinical and molecular features of a family with focal hand dystonia caused by DYT1 mutation. Four members of a family who underwent thalamotomy showed a marked and sustained therapeutic benefit that lasted for up to 12 years without recurrence of dystonia or any significant surgical complication. The hand dystonia caused by DYT1 mutation may be successfully managed by thalamotomy. © 2008 Movement Disorder Society
In‐state tuition for the undocumented: Education effects on Mexican young adults
Authors: Kaushal Neeraj 
Published: September 2008

AbstractThis paper examines the effect of tuition subsidy in the form of in‐state tuition to undocumented students on the education of noncitizen Mexican young adults. The policy is found to be associated with a 2.5 percentage point increase in college enrollment (base mean = 8%), a 3.7 percentage point increase in the proportion of students with at least some college education (base mean = 10%), and a 1.3 percentage point increase in the proportion with at least an associate degree (base mean = 4%). These results are robust to a variety of specifications. When the analysis is restricted to samples more likely to be affected by the policy, point estimates become larger. The study finds no evidence that in‐state tuition policy for the undocumented adversely affects the educational outcomes of natives. © 2008 by the Association for Public Policy Analysis and Management.
Three conditions under which experiments and observational studies produce comparable causal estimates: New findings from within‐study comparisons
Authors: Cook Thomas D. , Shadish William R. , Wong Vivian C. 
Published: September 2008

AbstractThis paper analyzes 12 recent within‐study comparisons contrasting causal estimates from a randomized experiment with those from an observational study sharing the same treatment group. The aim is to test whether different causal estimates result when a counterfactual group is formed, either with or without random assignment, and when statistical adjustments for selection are made in the group from which random assignment is absent. We identify three studies comparing experiments and regression‐discontinuity (RD) studies. They produce quite comparable causal estimates at points around the RD cutoff. We identify three other studies where the quasi‐experiment involves careful intact group matching on the pretest. Despite the logical possibility of hidden bias in this instance, all three cases also reproduce their experimental estimates, especially if the match is geographically local. We then identify two studies where the treatment and nonrandomized comparison groups manifestly differ at pretest but where the selection process into treatment is completely or very plausibly known. Here too, experimental results are recreated. Two of the remaining studies result in correspondent experimental and nonexperimental results under some circumstances but not others, while two others produce different experimental and nonexperimental estimates, though in each case the observational study was poorly designed and analyzed. Such evidence is more promising than what was achieved in past within‐study comparisons, most involving job training. Reasons for this difference are discussed. © 2008 by the Association for Public Policy Analysis and Management.
Compensation rules for climate policy in the electricity sector
Authors: Burtraw Dallas , Palmer Karen 
Published: September 2008

AbstractMost previous cap and trade programs have distributed emission allowances for free to incumbent producers. However, in the electricity sector the value of CO2 allowances may be far in excess of costs to industry and giving them away to firms diverts allowance value from other purposes. Using a detailed simulation model, this paper shows that compensation to firms losing asset value under a climate cap and trade policy can be achieved for a small fraction of total allowance value, if targeted carefully. However, the economic efficiency cost of providing incremental compensation to reach the fully compensated level is many multiples of that incremental compensation. These considerations might move policymakers away from free allocation of CO2 emission allowances in the electricity sector. © 2008 by the Association for Public Policy Analysis and Management.
Minimum wages and the economic well‐being of single mothers
Authors: Sabia Joseph J. 
Published: September 2008

AbstractUsing pooled cross‐sectional data from the 1992 to 2005 March Current Population Survey (CPS), this study examines the relationship between minimum wage increases and the economic well‐being of single mothers. Estimation results show that minimum wage increases were ineffective at reducing poverty among single mothers. Most working single mothers were not affected by minimum wage hikes because they already earned wages above state and federal minimum wages. And less‐educated single mothers who were affected did not see a rise in net income because of negative employment and hours effects. For this low‐skilled population, a 10 percent increase in the minimum wage was associated with an 8.8 percent reduction in employment and an 11.8 percent reduction in annual hours worked. © 2008 by the Association for Public Policy Analysis and Management