bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distributed moving horizon fusion estimation for linear constrained uncertain systems
Authors: Wang Shoudong , Xue Binqiang 
Published: April 2024

AbstractIn this paper, the distributed moving horizon fusion estimation of uncertain systems with constraints of system noise and state variables is studied. Firstly, relying on the basic idea of consensus algorithm, the cost function in the performance index is reconstructed by weighted fusion of the state prediction values. Secondly, considering the performance index with uncertain parameters, the min‐max optimization problem of the algorithm is transformed into the least squares optimization problem based on 2‐norm regularization method. Thirdly, the scalar‐weighted linear minimum variance fusion estimation strategy is used to realize the weighted fusion of local state estimation values. Then, on the premise of minimum network connectivity and collective observability, the stability of the proposed algorithm is studied, and the sufficient conditions for the expected convergence of the fused estimation error norm square are given. Finally, the effectiveness of the algorithm is verified by numerical simulation.
Das LT‐Brückenbauverfahren zur materialsparenden und schnellen Errichtung von Spannbetonbrücken
Authors: Untermarzoner Franz , Rath Michael , Kollegger Johann 
Published: April 2024

AbstractBauherren von Infrastrukturbauwerken stehen in den kommenden Jahren vor enormen Herausforderungen. Viele Ingenieurbauwerke, insbesondere Brücken, müssen saniert oder neu gebaut werden. Sie halten entweder den aktuellen Belastungen nicht mehr stand oder weisen Dauerhaftigkeitsprobleme auf. Gespräche mit Bauherren haben gezeigt, dass ein zügiger Baufortschritt bei Ersatzneubauten von entscheidender Bedeutung ist. Die Baustellen sollen den normalen Verkehrsfluss so wenig wie möglich beeinträchtigen. Demzufolge wurde ein neues, ressourcenschonendes und schnelles Bauverfahren für Brücken entwickelt. Um den genannten Anforderungen gerecht zu werden, wurden innovative Fertigteilelemente für die Längsträger und die Fahrbahnplatte entworfen. Diese werden durch Anschlussbewehrung und eine Ortbetonschicht auf der Baustelle verbunden. Ein Vergleich der Umweltauswirkungen basierend auf den Baustoffen (Lebenszyklusphasen A1–A3) zwischen einem Bauabschnitt einer LT‐Brücke und einer typischen deutschen Autobahnbrücke zeigt ein geringeres Treibhauspotenzial der neuen Brückenbaumethode aufgrund der Einsparung von Baustoffen. Die Durchführbarkeit dieser neuen Baumethode wird anhand eines bereits ausgeführten Pilotprojekts in Österreich gezeigt.
Recent advances in the synthesis of single‐stranded DNA in vitro
Authors: Li Shuai , Tan Wei , Jia Xuemei , Miao Qing , Liu Ying , Yang Dayong 
Published: April 2024

AbstractSingle‐stranded DNA (ssDNA) is the foundation of modern biology, with wide applications in gene editing, sequencing, DNA information storage, and materials science. However, synthesizing ssDNA with high efficiency, high throughput, and low error rate in vitro remains a major challenge. Various methods have been developed for ssDNA synthesis, and some significant results have been achieved. In this review, six main methods were introduced, including solid‐phase oligonucleotide synthesis, terminal deoxynucleotidyl transferase‐based ssDNA synthesis, reverse transcription, primer exchange reaction, asymmetric polymerase chain reaction, and rolling circle amplification. The advantages and limitations of each method were compared, as well as illustrate their representative achievements and applications. Especially, rolling circle amplification has received significant attention, including ssDNA synthesis, assembly, and application based on recent work. Finally, the future challenges and opportunities of ssDNA synthesis were summarized and discussed. Envisioning the development of new methods and significant progress will be made in the near future with the efforts of scientists around the world.
Cardiovascular toxicity with CTLA‐4 inhibitors in cancer patients: A meta‐analysis
Authors: Liu Huiyi , Fu Lu , Jin Shuyu , Ye Xingdong , Chen Yanlin , Pu Sijia , Xue Yumei 
Published: April 2024

AbstractBackgroundWith the emergence of cytotoxic T lymphocyte‐associated protein‐4 (CTLA‐4) inhibitors, the outcomes of patients with malignant tumors have improved significantly. However, the incidence of cardiovascular adverse events has also increased, which can affect tumor treatment. In this study, we evaluated the incidence and severity of adverse cardiovascular events caused by CTLA‐4 inhibitors by analyzing reported trials that involved CTLA‐4 inhibitor therapy.MethodsRandomized clinical trials published in English from January 1, 2013, to November 30, 2022, were searched using the Cochrane Library and PubMed databases. All included trials examined all grade and grades 3–5 cardiac and vascular adverse events. These involved comparisons of CTLA‐4 inhibitors to placebo, CTLA‐4 inhibitors plus chemotherapy to chemotherapy alone, CTLA‐4 inhibitors combined with PD‐1/PD‐L1 inhibitors to PD‐1/PD‐L1 inhibitors alone, and CTLA‐4 inhibitors plus target agent to PD‐1/PD‐L1 inhibitors plus target agent. The odds ratio (OR) and corresponding 95% confidence intervals (CIs) were calculated using the Mantel‐Haenszel method.ResultsOverall, 20 trials were included. CTLA‐4 inhibitors significantly increased the incidence of all‐grade cardiovascular toxicity (OR = 1.33, 95% CI: 1.00–1.75, p = 0.05). The incidence of all‐grade cardiovascular toxicity increased in malignant tumor patients who received single‐agent CTLA‐4 inhibitors (OR = 1.73, 95% CI: 1.13–2.65, p = 0.01), as well as the incidence rate of grades 3–5 cardiovascular adverse events (OR = 2.00, 95% CI: 1.08–3.70, p = 0.03). Compared with the non‐CTLA‐4 inhibitor group, CTLA‐4 inhibitors plus chemotherapy, PD‐1/PD‐L1 inhibitors, or target agent did not significantly affect the incidence of cardiac and vascular toxicity. The incidence of grades 3–5 cardiac failure, hypertension, pericardial effusion, myocarditis, and atrial fibrillation were much higher among patients exposed to CTLA‐4 inhibitor, but the data were not statistically significant.ConclusionOur findings suggest that the incidence rate of all cardiovascular toxicity and severe cardiovascular toxicity increased in patients who were administered CTLA‐4 inhibitors. In addition, the risk of serious cardiovascular toxic events was independent of the type of adverse event. From these results, physicians should assess the benefits and risks of CTLA‐4 inhibitors when treating malignancies.
LncRNA NEAT1 in the pathogenesis of liver‐related diseases
Authors: Saleh Raed Obaid , Alkhafaji Adnan Taan , Mohammed Jaafaru Sani , Bansal Pooja , Kaur Harpreet , Ahmad Irfan , Hjazi Ahmed , Mohammed Israa Hussein , Jawad Mohammed Abed , Zwamel Ahmed Hussein 
Published: April 2024

AbstractNuclear paraspeckle assembly transcript 1 (NEAT1) is a long noncoding RNA (lncRNA) that is widely expressed in a variety of mammalian cell types. Altered expression levels of the lncRNA NEAT1 have been reported in liver‐related disorders including cancer, fatty liver disease, liver fibrosis, viral hepatitis, and hepatic ischemia. lncRNA NEAT1 mostly acts as a competing endogenous RNA (ceRNA) to sponge various miRNAs (miRs) to regulate different functions. In regard to hepatic cancers, the elevated expression of NEAT1 has been reported to have a relation with the proliferation, migration, angiogenesis, apoptosis, as well as epithelial‐mesenchymal transition (EMT) of cancer cells. Furthermore, NEAT1 upregulation has contributed to the pathogenesis of other liver diseases such as fibrosis. In this review, we summarize and discuss the molecular mechanisms by which NEAT1 contributes to liver‐related disorders including acute liver failure, nonalcoholic fatty liver disease (NAFLD), liver fibrosis, and liver carcinoma, providing novel insights and introducing NEAT1 as a potential therapeutic target in these diseases.
An Air and Moisture Stable Boat Shaped Hydroxo‐Bridged Ruthenium(II) Binuclear Complex for the Catalytic Hydrogenation of CO2
Authors: Das Uttam K. , Tizzard Graham J. , Coles Simon J. , Owen Gareth R. 
Published: April 2024

AbstractA new hydroxo‐bridged ruthenium (II) complex [{Ru(η6‐p‐cymene)(iPr2P−O)}2(μ‐OH)]Cl (2) has fortuitously been isolated from the reaction between the known ruthenium(II) complex [RuCl2(η6‐p‐cymene)(iPr2P‐OH)] (1) in either CDCl3 or CHCl3 solutions in the presence of excess DBU (1,8‐diazabicyclo(5.4.0)undec‐7‐ene) at room temperature. Complex 2 is only formed under specific conditions as an orange‐colored air and moisture stable binuclear complex. It is formed via the deprotonation of the P−OH unit in [RuCl2(η6‐p‐cymene)(iPr2P‐OH)]. Complex 2 has been fully characterized by spectroscopic and analytical methods. Its structure was determined by single crystal X‐ray diffraction which reveals a boat‐shaped motif containing a bridging hydroxide unit which undergoes hydrogen bonding with a chloride counterion. Complex 2 was utilized as a catalyst for the hydrogenation of CO2 to formic acid salt using molecular hydrogen. The catalytic reactions were performed at 100 °C in THF in the presence of DBU as a base to isolate [DBU+H][OC(O)H] salt as the final product. Using catalyst loadings down to 0.01 mol%, it was possible to hydrogenate gaseous CO2 with TONs up to 9900.
Variation in Catalytic Efficacies of a 2D pH‐Stable MOF by Altering Activation Methods
Authors: Behera Janaki , Pal Arun , Sahoo Rupam , Das Madhab C. 
Published: April 2024

AbstractAlthough it is well‐known that the Lewis acidity of Metal‐Organic Frameworks (MOFs) can effectively enhance their catalytic activity in organic transformations, access to these Lewis‐acidic sites remains a key hurdle to widespread applications of Lewis‐acidic catalysis by MOFs. Easy accessibility of strong Lewis acidic sites onto 2D MOFs by using proper activation methods can be a cornerstone in attaining desired catalytic performance. Herein, we report a new 2D chemically stable MOF, IITKGP‐60, which displayed excellent framework robustness over a wide pH range (2–12). Benefiting from the abundant open metal sites (OMSs) and framework robustness, the catalytic activity of the developed material was explored in one‐pot three‐component Strecker reaction and Knoevenagel condensation reaction. Moreover, the developed catalyst is superior in catalyzing the reactions involving sterically hindered substrate (1‐naphthaldehyde) with high turnover number. A comparative catalytic study was conducted using different activation methods (chloroform and methanol exchanged activated samples), highlighting the significant effect of activation methods on its catalytic performances. The sustainable synthetic pathway under solvent‐free conditions for a broad scope of substrates using low catalyst loading and excellent recyclability made the developed pH‐stable framework a promising heterogeneous catalyst.
Synthesis of Calix[4]arene‐Based Porous Organic Cages and Their Gas Adsorption
Authors: Kong Qidi , Liu Lei‐Lei , Li Zhongyue 
Published: April 2024

AbstractTwo crystalline large‐sized porous organic cages (POCs) based on conical calix[4]arene (C4A) were designed and synthesized. The four‐jaw C4A unit tends to follow the face‐directed self‐assembly law with the planar triangular building blocks such as tris(4‐aminophenyl)amine (TAPA) or 1,3,5‐tris(4‐aminophenyl)benzene (TAPB) to generate a predictable cage with a stoichiometry of [6+8]. The formation of the large cages is confirmed through their relative molecular mass measured using MALDI‐TOF/TOF spectra. The protonated molecular ion peaks of C4A‐TAPA and C4A‐TAPB were observed at m/z 5109.0 (calculated for C336H240O24N32: m/z 5109.7) and m/z 5594.2 (calculated for C384H264O24N24: m/z 5598.4). C4A‐POCs exhibit I‐type N2 adsorption‐desorption isotherms with the BET surface areas of 1444.9 m2 ⋅ g−1 and 1014.6 m2 ⋅ g−1. The CO2 uptakes at 273 K are 62.1 cm3 ⋅ g−1 and 52.4 cm3 ⋅ g−1 at a pressure of 100 KPa. The saturated iodine vapor static uptakes at 348 K are 3.9 g ⋅ g−1 and 3.5 g ⋅ g−1. The adsorption capacity of C4A‐TAPA for SO2 reaches to 124.4 cm3 ⋅ g−1 at 298 K and 1.3 bar. Additionally, the adsorption capacities of C4A‐TAPA for C2H2, C2H4, and C2H6 were evaluated.
A Highly Sterically Encumbered Boron Lewis Acid Enabled by an Organotellurium‐Based Ligand
Authors: Wegener Daniel , Pérez‐Bitrián Alberto , Limberg Niklas , Wiesner Anja , Hoffmann Kurt F. , Riedel Sebastian 
Published: April 2024

AbstractLewis acidic boron compounds are ubiquitous in chemistry due to their numerous applications, yet tuning and optimizing their properties towards different purposes is still a challenging field of research. In this work, the boron‐based Lewis acid B[OTeF3(C6F5)2]3 was synthesized by reaction of the teflate derivative HOTeF3(C6F5)2 with BCl3 or BCl3 ⋅ SMe2. This new compound presents a remarkably high thermal stability up to 300 °C, as well as one of the most sterically encumbered boron centres known in the literature. Theoretical and experimental methods revealed that B[OTeF3(C6F5)2]3 exhibits a comparable Lewis acidity to that of the well‐known B(C6F5)3. The affinity of B[OTeF3(C6F5)2]3 towards pyridine was accessed by Isothermal Titration Calorimetry (ITC) and compared to that of B(OTeF5)3 and B(C6F5)3. The ligand‐transfer reactivity of this new boron compound towards different fluorides was demonstrated by the formation of an anionic Au(III) complex and a hypervalent iodine(III) species.
Probing actin‐activated ATP turnover kinetics of human cardiac myosin II by single molecule fluorescence
Authors: Berg Albin , Velayuthan Lok Priya , Tågerud Sven , Ušaj Marko , Månsson Alf 
Published: April 2024

AbstractMechanistic insights into myosin II energy transduction in striated muscle in health and disease would benefit from functional studies of a wide range of point‐mutants. This approach is, however, hampered by the slow turnaround of myosin II expression that usually relies on adenoviruses for gene transfer. A recently developed virus‐free method is more time effective but would yield too small amounts of myosin for standard biochemical analyses. However, if the fluorescent adenosine triphosphate (ATP) and single molecule (sm) total internal reflection fluorescence microscopy previously used to analyze basal ATP turnover by myosin alone, can be expanded to actin‐activated ATP turnover, it would appreciably reduce the required amount of myosin. To that end, we here describe zero‐length cross‐linking of human cardiac myosin II motor fragments (sub‐fragment 1 long [S1L]) to surface‐immobilized actin filaments in a configuration with maintained actin‐activated ATP turnover. After optimizing the analysis of sm fluorescence events, we show that the amount of myosin produced from C2C12 cells in one 60 mm cell culture plate is sufficient to obtain both the basal myosin ATP turnover rate and the maximum actin‐activated rate constant (k
cat). Our analysis of many single binding events of fluorescent ATP to many S1L motor fragments revealed processes reflecting basal and actin‐activated ATPase, but also a third exponential process consistent with non‐specific ATP‐binding outside the active site.
Improved Thermoelectric Properties of Selenium Functionalized Pedot
Authors: Maity Shilpa , Mondal Aniket , Das Sukhen , Chatterjee Krishanu 
Published: April 2024

AbstractPolymer‐based chalcogenide composites are gaining attention for thermal energy storage thermoelectric (TE) applications due to their high Seebeck coefficient (S) and electrical conductivity (σ), compared to low thermal conductivity of polymers without electrical optimization. This combination can enhance power factor and ZT while suppressing drawbacks. The energy‐filtering effect of polymer/chalcogenide interfaces may also improve TE performance, further enhancing the potential for improved TE applications. In this work, Poly(3,4‐ethylenedioxythiophene) (PEDOT) was functionalized with selenium (Se), and its structural and thermoelectric (TE) properties were studied. The variations of σ and S, with higher percent of Se content, displays a simultaneous rise in both σ and S values, which is noteworthy. The probable reason behind this increment of both σ and S values is due to the improvement in charge transport in the composites due to a percolating network formed between the Se nanoparticles and PEDOT along with the carrier energy filtering interaction between PEDOT and Se. The highest room temperature ZT value obtained is 0.027 for 82 % of Se content in PEDOT, which is comparable with bulk nanostructured organic‐inorganic hybrid composite materials. This work presents an efficient technique for enhancing the TE properties of polymers through inorganic functionalization.
Wireless Multimodal Light‐Emitting Arrays Operating on the Principles of LEDs and ECL
Authors: Liu Miaoxia , Arias‐Aranda Leslie R. , Li Haidong , Bouffier Laurent , Kuhn Alexander , Sojic Neso , Salinas Gerardo 
Published: April 2024

AbstractElectrochemistry‐based light‐emitting devices have gained considerable attention in different applications such as sensing and optical imaging. In particular, such systems are an interesting alternative for the development of multimodal light‐emitting platforms. Herein we designed a multicolor light‐emitting array, based on the electrochemical switch‐on of light‐emitting diodes (LEDs) with a different intrinsic threshold voltage. Thermodynamically and kinetically favored coupled redox reactions, i. e. the oxidation of Mg and the reduction of protons on Pt, act as driving force to power the diodes. Moreover, this system enables to trigger an additional light emission based on the interfacial reductive‐oxidation electrochemiluminescence (ECL) mechanism of the Ru(bpy)32+/S2O82− system. The synergy between these light‐emission pathways offers a multimodal platform for the straightforward optical readout of physico‐chemical information based on composition changes of the solution.
Effect of Anchoring Dynamics on Proton‐Coupled Electron Transfer in the Ru(bda) Coordination Oligomer on a Graphitic Surface
Authors: Calvani Dario , Louwersheimer Rick , Buda Francesco 
Published: April 2024

AbstractThe oligomeric ruthenium‐based water oxidation catalyst, Ru(bda), is known to be experimentally anchored on graphitic surfaces through CH‐π stacking interactions between the auxiliary bda ([2,2′‐bipyridine]‐6,6′‐dicarboxylate) ligand bonded to ruthenium and the hexagonal rings of the surface. This anchoring provides control over their molecular coverage and enables efficient catalysis of water oxidation to dioxygen. The oligomeric nature of the molecule offers multiple anchoring sites at the surface, greatly enhancing the overall stability of the hybrid catalyst‐graphitic surface anode through dynamic bonding. However, the impact of this dynamic anchoring on the overall catalytic mechanism is still a topic of debate. In this study, a crucial proton‐coupled electron transfer event in the catalytic cycle is investigated using DFT‐based molecular dynamics simulations plus metadynamics. The CH‐π stacking anchoring plays a critical role not only in stabilizing this hybrid system but also in facilitating the proton‐coupled electron transfer event with possible vibronic couplings between the anchoring bonds motion and charge fluctuations at the catalyst – graphitic surface interface. Furthermore, this computational investigation displays the presence of a quartet spin state intermediate that can lead to the experimentally observed and thermodynamically more stable doublet spin state.
Performance evaluation of rock fragmentation prediction based on RF‐BOA, AdaBoost‐BOA, GBoost‐BOA, and ERT‐BOA hybrid models
Authors: Zhao Junjie , Li Diyuan , Zhou Jian , Armaghani Danial J. , Zhou Aohui 
Published: April 2024

AbstractRock fragmentation is an important indicator for assessing the quality of blasting operations. However, accurate prediction of rock fragmentation after blasting is challenging due to the complicated blasting parameters and rock properties. For this reason, optimized by the Bayesian optimization algorithm (BOA), four hybrid machine learning models, including random forest, adaptive boosting, gradient boosting, and extremely randomized trees, were developed in this study. A total of 102 data sets with seven input parameters (spacing‐to‐burden ratio, hole depth‐to‐burden ratio, burden‐to‐hole diameter ratio, stemming length‐to‐burden ratio, powder factor, in situ block size, and elastic modulus) and one output parameter (rock fragment mean size, X50) were adopted to train and validate the predictive models. The root mean square error (RMSE), the mean absolute error (MAE), and the coefficient of determination () were used as the evaluation metrics. The evaluation results demonstrated that the hybrid models showed superior performance than the standalone models. The hybrid model consisting of gradient boosting and BOA (GBoost‐BOA) achieved the best prediction results compared with the other hybrid models, with the highest R2 value of 0.96 and the smallest values of RMSE and MAE of 0.03 and 0.02, respectively. Furthermore, sensitivity analysis was carried out to study the effects of input variables on rock fragmentation. In situ block size (XB), elastic modulus (E), and stemming length‐to‐burden ratio (T/B) were set as the main influencing factors. The proposed hybrid model provided a reliable prediction result and thus could be considered an alternative approach for rock fragment prediction in mining engineering.
It's about time: Feeding competition costs of sociality are affected more by temporal characteristics than spatial distribution
Authors: Ekanayake‐Weber Marcy , Mathew Namita , Cunha Deanna , Payen Nathanael , Grimm Volker , Koenig Andreas 
Published: April 2024

AbstractFor most herbivorous animals, group‐living appears to incur a high cost by intensifying feeding competition. These costs raise the question of how gregariousness (i.e., the tendency to aggregate) could have evolved to such an extent in taxa such as anthropoid primates and ungulates. When attempting to test the potential benefits and costs, previous foraging models demonstrated that group‐living might be beneficial by lowering variance in intake, but that it reduces overall foraging success. However, these models did not fully account for the fact that gregariousness has multiple experiences and can vary in relation to ecological variables and foraging competition. Here, we present an agent‐based model for testing how ecological variables impact the costs and benefits of gregariousness. In our simulations, primate‐like agents forage on a variable resource landscape while maintaining spatial cohesion with conspecifics to varying degrees. The agents' energy intake rate, daily distance traveled, and variance in energy intake were recorded. Using Morris Elementary Effects sensitivity analysis, we tested the sensitivity of 10 model parameters, of which 2 controlled gregarious behavior and 8 controlled food resources, including multiple aspects of temporal and spatial heterogeneity. We found that, while gregariousness generally increased feeding competition, the costs of gregariousness were much lower when resources were less variable over time (i.e., when calorie extraction was slow and resource renewal was frequent). We also found that maintaining proximity to other agents resulted in lower variance in energy intake when resources were more variable over time. Thus, it appears that the costs and benefits of gregariousness are strongly influenced by the temporal characteristics of food resources, giving insight into the pressures that shaped the evolution of sociality and group living, including in our own lineage.