bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward High‐Performance Hydrogenation at Room Temperature Through Tailoring Nickel Catalysts Stable in Aqueous Solution
Authors: Zou Zidan , Shen Yue , Zhang Xiao , Li Wenchao , Chen Chun , Fan Diancai , Zhang Haimin , Zhao Huijun , Wang Guozhong 
Published: April 2024

AbstractThe development of highly active, reusable catalysts for aqueous‐phase reactions is challenging. Herein, metallic nickel is encapsulated in a nitrogen‐doped carbon–silica composite (SiO2@Ni@NC) as a catalyst for the selective hydrogenation of vanillin in aqueous media. The constructed catalyst achieved 99.8% vanillin conversion and 100% 4‐hydroxymethyl‐2‐methoxyphenol selectivity at room temperature. Based on combined scanning transmission electron microscopy, X‐ray photoelectron spectroscopy, and Raman analyses, the satisfactory catalytic performance is attributed to the composite structure consisting of an active metal, carbon, and silica. The hydrophilic silica core promoted dispersion of the catalyst in aqueous media. Moreover, the external hydrophobic NC layer has multiple functions, including preventing oxidation or leaching of the internal metal, acting as a reducing agent to reduce the internal metal, regulating the active‐site microenvironment by enriching the concentrations of H2 and organic reactants, and modifying the electronic structure of the active metal via metal–support interactions. Density functional theory calculations indicated that NC facilitates vanillin adsorption and hydrogen dissociation to promote aqueous‐phase hydrogenation. This study provides an efficient strategy for constructing encapsulated Ni‐based amphiphilic catalysts to upgrade biomass‐derived compounds.
Reactive Microneedle Patches with Antibacterial and Dead Bacteria‐Trapping Abilities for Skin Infection Treatment
Authors: Shan Jingyang , Wu Xiangyi , Che Junyi , Gan Jingjing , Zhao Yuanjin 
Published: April 2024

AbstractBacterial skin infections are highly prevalent and pose a significant public health threat. Current strategies are primarily focused on the inhibition of bacterial activation while disregarding the excessive inflammation induced by dead bacteria remaining in the body and the effect of the acidic microenvironment during therapy. In this study, a novel dual‐functional MgB2 microparticles integrated microneedle (MgB2 MN) patch is presented to kill bacteria and eliminate dead bacteria for skin infection management. The MgB2 microparticles not only can produce a local alkaline microenvironment to promote the proliferation and migration of fibroblasts and keratinocytes, but also achieve >5 log bacterial inactivation. Besides, the MgB2 microparticles effectively mitigate dead bacteria‐induced inflammation through interaction with lipopolysaccharide (LPS). With the incorporation of these MgB2 microparticles, the resultant MgB2 MN patches effectively kill bacteria and capture dead bacteria, thereby mitigating these bacteria‐induced inflammation. Therefore, the MgB2 MN patches show good therapeutic efficacy in managing animal bacterial skin infections, including abscesses and wounds. These results indicate that reactive metal borides‐integrated microneedle patches hold great promise for the treatment of clinical skin infections.
Perspectives Toward Damage‐Tolerant Nanostructure Ceramics
Authors: Fan Meicen , Wen Tongqi , Chen Shile , Dong Yanhao , Wang Chang‐An 
Published: April 2024

AbstractAdvanced ceramic materials and devices call for better reliability and damage tolerance. In addition to their strong bonding nature, there are examples demonstrating superior mechanical properties of nanostructure ceramics, such as damage‐tolerant ceramic aerogels that can withstand high deformation without cracking and local plasticity in dense nanocrystalline ceramics. The recent progresses shall be reviewed in this perspective article. Three topics including highly elastic nano‐fibrous ceramic aerogels, load‐bearing nanoceramics with improved mechanical properties, and implementing machine learning‐assisted simulations toolbox in understanding the relationship among structure, deformation mechanisms, and microstructure‐properties shall be discussed. It is hoped that the perspectives present here can help the discovery, synthesis, and processing of future structural ceramic materials that are insensitive to processing flaws and local damages in service.
Electropolymerization of Donor–Acceptor Conjugated Polymer for Efficient Dual‐Ion Storage
Authors: Chen Xianhe , Zhang Weisheng , Zhang Chenxing , Guo Yuxuan , Yu Ao , Mei Shilin , Yao Chang‐Jiang 
Published: April 2024

AbstractRationally designed organic redox‐active materials have attracted numerous interests due to their excellent electrochemical performance and reasonable sustainability. However, they often suffer from poor cycling stability, intrinsic low operating potential, and poor rate performance. Herein, a novel Donor–Acceptor (D–A) bipolar polymer with n‐type pyrene‐4,5,9,10‐tetraone unit storing Li cations and p‐type carbazole unit which attracts anions and provides polymerization sites is employed as a cathode for lithium‐ion batteries through in situ electropolymerization. The multiple redox reactions and boosted kinetics by the D–A structure lead to excellent electrochemical performance of a high discharge capacity of 202 mA h g−1 at 200 mA g−1, impressive working potential (2.87 and 4.15 V), an outstanding rate capability of 119 mA h g−1 at 10 A g−1 and a noteworthy energy density up to 554 Wh kg−1. This strategy has significant implications for the molecule design of bipolar organic cathode for high cycling stability and high energy density.
H2O‐Mg2+ Waltz‐Like Shuttle Enables High‐Capacity and Ultralong‐Life Magnesium‐Ion Batteries
Authors: Ma Xiu‐Fen , Zhao Bai‐Qing , Liu Hongyu , Tan Jing , Li Hong‐Yi , Zhang Xie , Diao Jiang , Yue Jili , Huang Guangsheng , Wang Jingfeng , Pan Fusheng 
Published: April 2024

AbstractMg‐ion batteries (MIBs) are promising next‐generation secondary batteries, but suffer from sluggish Mg2+ migration kinetics and structural collapse of the cathode materials. Here, an H2O‐Mg2+ waltz‐like shuttle mechanism in the lamellar cathode, which is realized by the coordination, adaptive rotation and flipping, and co‐migration of lattice H2O molecules with inserted Mg2+, leading to the fast Mg2+ migration kinetics, is reported; after Mg2+ extraction, the lattice H2O molecules rearrange to stabilize the lamellar structure, eliminating structural collapse of the cathode. Consequently, the demo cathode of Mg0.75V10O24·nH2O (MVOH) exhibits a high capacity of 350 mAh g−1 at a current density of 50 mA g−1 and maintains a capacity of 70 mAh g−1 at 4 A g−1. The full aqueous MIB based on MVOH delivers an ultralong lifespan of 5000 cycles The reported waltz‐like shuttle mechanism of lattice H2O provides a novel strategy to develop high‐performance cathodes for MIBs as well as other multivalent‐ion batteries.
Innovative Bio‐based Hydrogel Microspheres Micro‐Cage for Neutrophil Extracellular Traps Scavenging in Diabetic Wound Healing
Authors: Xiao Yongqiang , Ding Tao , Fang He , Lin Jiawei , Chen Lili , Ma Duan , Zhang Tianyu , Cui Wenguo , Ma Jing 
Published: April 2024

AbstractNeutrophil extracellular traps (NETs) seriously impede diabetic wound healing. The disruption or scavenging of NETs using deoxyribonuclease (DNase) or cationic nanoparticles has been limited by liberating trapped bacteria, short half‐life, or potential cytotoxicity. In this study, a positive correlation between the NETs level in diabetic wound exudation and the severity of wound inflammation in diabetic patients is established. Novel NETs scavenging bio‐based hydrogel microspheres ‘micro‐cage’, termed mPDA‐PEI@GelMA, is engineered by integrating methylacrylyl gelatin (GelMA) hydrogel microspheres with cationic polyethyleneimine (PEI)‐functionalized mesoporous polydopamine (mPDA). This unique ‘micro‐cage’ construct is designed to non‐contact scavenge of NETs between nanoparticles and the diabetic wound surface, minimizing biological toxicity and ensuring high biosafety. NETs are introduced into ‘micro‐cage’ along with wound exudation, and cationic mPDA‐PEI immobilizes them inside the ‘micro‐cage’ through a strong binding affinity to the cfDNA web structure. The findings demonstrate that mPDA‐PEI@GelMA effectively mitigates pro‐inflammatory responses associated with diabetic wounds by scavenging NETs both in vivo and in vitro. This work introduces a novel nanoparticle non‐contact NETs scavenging strategy to enhance diabetic wound healing processes, with potential benefits in clinical applications.
Genome Editing VEGFA Prevents Corneal Neovascularization In Vivo
Authors: Zeng Zhenhai , Li Siheng , Ye Xiuhong , Wang Yiran , Wang Qinmei , Chen Zhongxing , Wang Ziqian , Zhang Jun , Wang Qing , Chen Lu , Zhang Shuangzhe , Zou Zhilin , Lin Meimin , Chen Xinyi , Zhao Guoli , McAlinden Colm , Lei Hetian , Zhou Xingtao , Huang Jinhai 
Published: April 2024

AbstractCorneal neovascularization (CNV) is a common clinical finding seen in a range of eye diseases. Current therapeutic approaches to treat corneal angiogenesis, in which vascular endothelial growth factor (VEGF) A plays a central role, can cause a variety of adverse side effects. The technology of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 can edit VEGFA gene to suppress its expression. CRISPR offers a novel opportunity to treat CNV. This study shows that depletion of VEGFA with a novel CRISPR/Cas9 system inhibits proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs) in vitro. Importantly, subconjunctival injection of this dual AAV‐SpCas9/sgRNA‐VEGFA system is demonstrated which blocks suture‐induced expression of VEGFA, CD31, and α‐smooth muscle actin as well as corneal neovascularization in mice. This study has established a strong foundation for the treatment of corneal neovascularization via a gene editing approach for the first time.
Flexible 3D Plasmonic Web Enables Remote Surface Enhanced Raman Spectroscopy
Authors: Rodríguez‐Sevilla Erika , Álvarez‐Martínez Jonathan Ulises , Castro‐Beltrán Rigoberto , Morales‐Narváez Eden 
Published: April 2024

AbstractNanoplasmonic materials concentrate light in specific regions of dramatic electromagnetic enhancement: hot spots. Such regions can be employed to perform single molecule detection via surface‐enhanced Raman spectroscopy. However, this phenomenon is challenging since hot spots are expected to be highly intense/abundant and positioning of molecules within such hot spots is crucial to manage with ultrasensitive SERS. Herein, it is discovered that a 3D plasmonic web embedded within a biohybrid (3D‐POWER) exhibits plasmonic transmission, spontaneously absorbs the analyte, and meets these so much needed criteria in ultrasensitive SERS. 3D‐POWER is built with nanopaper and self‐assembled layers of graphene oxide and gold nanorods. According to in silico experiments, 3D‐POWER captures light in a small region and performs plasmonic field transmission in a surrounding volume, thereby activating a plasmonic web throughout the simulated volume. The study also provides experimental evidence supporting the plasmonic field transport ability of 3D power, which operates as a SERS signal carrier (even beyond the apparatus field of view), and the ultrasensitive behavior of this ecofriendly and flexible material facilitating yoctomolar limit of detection. Besides, 3D‐POWER is proven useful in food and biofluids analysis. It is foreseen that 3D‐POWER can be employed as a valuable platform in (bio)analytical applications.
Impact of alloy‐like phase on energy loss mitigation in multi‐component organic photovoltaics
Authors: Kong Xiangyue , Zhan Lingling , Li Zhongjie , Yang Yaxin , Liu Yuhao , Qiu Huayu , Sun Xiaokang , Hu Hanlin , Sun Rui , Min Jie , Yin Shouchun , Fu Weifei , Chen Hongzheng 
Published: April 2024

AbstractThe multi‐component strategy has proven effective in advancing the performance of organic photovoltaics (OPVs), enhancing photocurrent and fill factor through spectral complementarity and morphology optimization. However, the open‐circuit voltage (VOC) mechanism in multi‐component systems lacks systematic investigation. In this study, we explore the influence of alloy‐like phases on energy level distribution and energy loss mechanisms in multi‐component OPVs. Appropriate modulation of donor alloy‐like phases maintains the original intermolecular stacking, enhances component compatibility, reduces acceptor aggregation, and improves acceptor phase purity, mitigating non‐radiative recombination losses. Additionally, suitable alloy‐like phase modulation elevates charge transfer (CT) states, reducing the gap between CT and local exciton state, lowering reorganization energy, and alleviating radiative recombination loss below the bandgap. Through synergistic optimization (layer‐by‐layer method with solid additive), ternary devices based on Y6 acceptor achieve a notable 19.41% power conversion efficiency, offering new insights for the analysis of the energy loss of the multi‐component OPVs.
Efficacy and safety of mammalian target of rapamycin inhibitors in systemic mastocytosis: A nationwide French pilot study
Authors: Moraly Josquin , Rossignol Julien , Rouzaud Claire , Gabas Thomas , Bouktit Hassiba , Lhermitte Ludovic , Canioni Danielle , Fraitag Sylvie , Bruneau Julie , Barete Stéphane , Suarez Felipe , Ballul Thomas , Meni Cécile , Polivka Laura , Terriou Louis , Launay David , Bouillet Laurence , Gaudy‐Marqueste Caroline , Gousseff Marie , Le Mouel Edwige , Neel Antoine , Ranta Dana , Jaussaud Roland , Guilpain Philippe , Frenzel Laurent , Agopian Julie , Dubreuil Patrice , Greco Céline , Dimicoli‐Salazar Sophie , Heiblig Mael , Gourguechon Clément , Tournilhac Olivier , Javier Rose‐Marie , Castelain Florence , Cabrera Quentin , Gourin Marie Pierre , Wierzbicka‐Hainaut Ewa , Torregrosa‐Diaz Jose Miguel , Bulai Cristina , Lavigne Christian , Hoarau Cyrille , Arock Michel , Damaj Gandhi , Lortholary Olivier , Hermine Olivier ,   CEREMAST network
Published: April 2024

AbstractSystemic mastocytosis (SM) corresponds to a rare and heterogeneous spectrum of diseases characterized by the accumulation of atypical mast cells (MCs). Advanced mastocytosis (Adv‐SM) is associated with poor survival; in contrast, patients with non‐advanced SM (non‐Adv‐SM) usually have a normal life expectancy but may experience poor quality of life. Despite recent therapeutic progress including tyrosine kinase inhibitors, new treatment options are needed for refractory and/or intolerant patients with both severely symptomatic and Adv‐SM. In vitro, the mTOR pathway is activated in MCs from patients bearing the KIT D816V mutation. Furthermore, rapamycin induces the apoptosis of KIT D816V MCs selectively. In this nationwide study, we report the outcomes of patients diagnosed with SM and treated with a mammalian target of rapamycin inhibitor (imTOR) within the French National Reference Center for mastocytosis (CEREMAST). All patients registered were relapsing, treatment‐refractory, or ineligible for other cytoreductive therapy. Non‐Adv‐SM patients received imTOR as a monotherapy (rapamycin/everolimus), and Adv‐SM patients received imTOR as a monotherapy or in combination with cytarabine. The objective response rate (ORR) in non‐Adv‐SM was 60% (partial response in 40% and major response in 20%), including reductions in skin involvement, mediator release symptoms, and serum tryptase. In the Adv‐SM group, the ORR was 20% (including one major response and one partial response, both in patients with a KIT D816V mutation), which enabled a successful bridge to allogeneic stem cell transplantation in one patient. Our results suggest that imTOR treatment has potential benefits in patients with SM harboring a KIT D816V mutation.
Against all odds: The road to success in the development of human immune reconstitution mice
Authors: Bin Yixiao , Ren Jing , Zhang Haowei , Zhang Tianjiao , Liu Peijuan , Xin Zhiqian , Yang Haijiao , Feng Zhuan , Chen Zhinan , Zhang Hai 
Published: April 2024

AbstractThe mouse genome has a high degree of homology with the human genome, and its physiological, biochemical, and developmental regulation mechanisms are similar to those of humans; therefore, mice are widely used as experimental animals. However, it is undeniable that interspecies differences between humans and mice can lead to experimental errors. The differences in the immune system have become an important factor limiting current immunological research. The application of immunodeficient mice provides a possible solution to these problems. By transplanting human immune cells or tissues, such as peripheral blood mononuclear cells or hematopoietic stem cells, into immunodeficient mice, a human immune system can be reconstituted in the mouse body, and the engrafted immune cells can elicit human‐specific immune responses. Researchers have been actively exploring the development and differentiation conditions of host recipient animals and grafts in order to achieve better immune reconstitution. Through genetic engineering methods, immunodeficient mice can be further modified to provide a favorable developmental and differentiation microenvironment for the grafts. From initially only being able to reconstruct single T lymphocyte lineages, it is now possible to reconstruct lymphoid and myeloid cells, providing important research tools for immunology‐related studies. In this review, we compare the differences in immune systems of humans and mice, describe the development history of human immune reconstitution from the perspectives of immunodeficient mice and grafts, and discuss the latest advances in enhancing the efficiency of human immune cell reconstitution, aiming to provide important references for immunological related researches.
Diagnostic Utility of MOG Antibody Testing in Cerebrospinal Fluid
Authors: Redenbaugh Vyanka , Fryer James P. , Cacciaguerra Laura , Chen John J. , Greenwood Tammy M. , Gilligan Michael , Thakolwiboon Smathorn , Majed Masoud , Chia Nicholas H , McKeon Andrew , Mills John R. , Lopez Chiriboga A. Sebastian , Tillema Jan‐Mendelt , Yang Binxia , Abdulrahman Yahya , Guo Kai , Vorasoot Nisa , Valencia Sanchez Cristina , Tajfirouz Deena A. , Toledano Michel , Zekeridou Anastasia , Dubey Divyanshu , Gombolay Grace Y , Caparó‐Zamalloa César , Kister Ilya , Pittock Sean J. , Flanagan Eoin P. 
Published: April 2024

ObjectiveThe aim of this study was to assess the diagnostic utility of cerebrospinal fluid (CSF) myelin oligodendrocyte glycoprotein antibodies (MOG‐IgG) testing.MethodsWe retrospectively identified patients for CSF MOG‐IgG testing from January 1, 1996, to May 1, 2023, at Mayo Clinic and other medical centers that sent CSF MOG‐IgG for testing including: controls, 282; serum MOG‐IgG positive MOG antibody‐associated disease (MOGAD), 74; serum MOG‐IgG negative high‐risk phenotypes, 73; serum false positive MOG‐IgG with alternative diagnoses, 18. A live cell‐based assay assessed CSF MOG‐IgG positivity (IgG‐binding‐index [IBI], ≥2.5) using multiple anti‐human secondary antibodies and end‐titers were calculated if sufficient sample volume. Correlation of CSF MOG‐IgG IBI and titer was assessed.ResultsThe pan‐IgG Fc‐specific secondary was optimal, yielding CSF MOG‐IgG sensitivity of 90% and specificity of 98% (Youden's index 0.88). CSF MOG‐IgG was positive in: 4/282 (1.4%) controls; 66/74 (89%) serum MOG‐IgG positive MOGAD patients; and 9/73 (12%) serum MOG‐IgG negative patients with high‐risk phenotypes. Serum negative but CSF positive MOG‐IgG accounted for 9/83 (11%) MOGAD patients, and all fulfilled 2023 MOGAD diagnostic criteria. Subgroup analysis of serum MOG‐IgG low‐positives revealed CSF MOG‐IgG positivity more in MOGAD (13/16[81%]) than other diseases with false positive serum MOG‐IgG (3/15[20%]) (p = 0.01). CSF MOG‐IgG IBI and CSF MOG‐IgG titer (both available in 29 samples) were correlated (Spearman's r = 0.64, p < 0.001).InterpretationCSF MOG‐IgG testing has diagnostic utility in patients with a suspicious phenotype but negative serum MOG‐IgG, and those with low positive serum MOG‐IgG results and diagnostic uncertainty. These findings support a role for CSF MOG‐IgG testing in the appropriate clinical setting. ANN NEUROL 2024;96:34–45
Bayesian Inference for Model Analyses of Supramolecular Complexes: A Case Study with Nanocarbon Hosts
Authors: Onaka Yuzuka , Sakai Renki , Fukunaga Toshiya M. , Ikemoto Koki , Isobe Hiroyuki 
Published: April 2024

AbstractA 126 π‐electron nanobowl molecule, phenine tridehydrosumanene, was synthesized in 12 steps through the development of a polygon cyclization strategy that assembled the polygonal precursors by Ni‐mediated macrocyclization. The bowl‐shaped structure accommodated C70 as a guest at the concave site, and the ball‐in‐bowl structure was determined by X‐ray crystallography. The host–guest equilibrium in solution was studied with titration experiments using isothermal calorimetry, which provided an interesting test case for studying the host–guest stoichiometry. Bayesian inference was introduced for stoichiometric analyses of the equilibrium, and a procedure to estimate the volume of prior probability in the parameter space was developed. The Bayesian procedure functioned as Occam's razor and provided quantitative support for a specific stoichiometry. The method was examined with five host–guest examples comprising nanocarbon hosts, which suggested the versatility of Bayesian inference for studies of supramolecular complexes.
Immobilization of N,N‐diallyl‐N,N‐dimethylammonium chloride on polyethylene. Biocidal properties of the material
Authors: Misin Vyacheslav M. , Zezin Alexey A. , Zezina Elena A. , Loiko Nataliya G. , Maltsev Alexander A. , Maltseva Irina E. , Grafov Oleg Yu , Prokhorov Valery V. , Pozin Sergey I. 
Published: April 2024

AbstractThe immobilization of N,N‐diallyl‐N,N‐dimethylammonium chloride (DADMAC) on low‐density polyethylene (LDPE) films was carried out by the method of postradiation grafting using x‐ray radiation. The introduction of polycation exchanger links provided the appearance of hydrophilicity of the surface of the modified film. By measuring the wetting contact angle, IR and SEM, the island‐type character of the coating from grafted polyDADMAC was detected. The death of Gram‐negative bacteria Pseudomonas aeruginosa, Gram‐positive bacteria Staphylococcus aureus, and yeast (eukaryotes) Yarrowia lipolytica on the surface of the film with grafted polyDADMAC was demonstrated.
Replacement tooth in mesosaurs and new data on dental microanatomy and microstructure
Authors: Carlisbino Thiago , de Farias Brodsky Dantas Macedo , Sedor Fernando Antonio , Soares Marina Bento , Schultz Cesar Leandro 
Published: April 2024

AbstractThe Permian mesosaurs are well known for being the earliest amniotes to exhibit adaptations for living in a marine environment (Irati‐Whitehill Sea). In addition to their set of skeletal features associated with aquatic dwelling life, their dentition includes important characteristics related to feeding in this habitat, which is described in this work, based on the analysis of mesosaur specimens from the Lower Permian Irati Formation of Brazil. Mesosaurs have several slender, conical teeth bordered by enamel apicobasal ridges, a feature predominantly found in aquatic amniotes. Internally, the dentine walls are formed by the arrangement of layers of orthodentine and globular dentine. To prevent tooth loss, the basal area is equipped with plicidentine, a particular type of orthodentine, allied with cementum, alveolar bone trabeculae, and periodontal space that reinforces anchorage and provides some flexibility. The teeth are replaced in a labio‐vertical path, and the dentition replaces alternately. This feature is regarded as plesiomorphic, and it ensures the oral cavity is supplied with enough teeth. However, these features do not the assessment of whether mesosaurs teeth were capable of piercing prey with resistant tegument. Instead, we interpret this adaptation as a mechanism for catching prey, at least in adults, and we endorse a possible ontogenetic dietary shift from small to large forms.