bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction Models of Cardiac Sparing during Deep Inspiration Breath-Hold in Left-sided Breast Cancer with Internal Mammary Node Irradiation
Authors: Sun Xiang-Lu , Zhang Yan-Qun , Wu Huan , Deng Hu , Sun Nan , Wu Xian-Xiang , Zhang Lei , Han Yang , Jiang Hao , Zhou Yong-Chun 
Published: February 2024

Abstract

Purpose To evaluate the cardiac dosimetric advantages of deep inspiration breath-hold (DIBH) in postoperative left-sided breast cancer patients undergoing internal mammary node irradiation (IMNI) and construct prediction models using factors influenced cardiac sparing through DIBH. Methods Forty-five postoperative left-sided breast cancer patients receiving IMNI were collected in this study continuously, and 2 simulated computed tomography (CT) scans were performed in the free breathing (FB) and DIBH. Anatomical parameters were measured based on the FB planning CT scans. Dosimetric parameters were then compared between DIBH and FB, and predictors of cardiac sparing during DIBH were analyzed. Results Compared to FB, DIBH reduced the dose parameters of Dmean, Dmax, and V5-V30for the heart and left anterior descending coronary artery (LAD) significantly (P < 0.05). Breast volume (BV), age and parasagittal cardiac contact distances (FB-CCDps) were related to mean heart dose reduction independently (P < 0.05), while initial LAD-to-manubrium distance (FB-LMD), BV, and age were identified as independent predictors of mean LAD dose reduction (P < 0.05). Mathematical prediction models were developed to predict cardiac sparing. Conclusions DIBH could effectively reduce the radiation dose for both of heart and LAD in postoperative left-sided breast cancer patients undergoing IMNI. The mathematical prediction models using BV, age, FB-LMD and FB-CCDps may help identify patients most likely to benefit from DIBH.
A new concept of the aortic artery bioprosthesis
Authors: Patralski Krzysztof 
Published: February 2024

Abstract
Background The aim of the analysis is to develop design principles for a new material having properties similar to those of the natural aortic artery. This involves replacing the complex structure of the aortic wall with a new material with a layer-composite structure having the same strength and hemodynamic properties. The structure of the material used to construct the new aortic prosthesis consists of three layers. Inner layer contains important fibers arranged in two orthogonal directions: circumferential and axial. The fibers are embedded in a liquid matrix, which, due to the characteristics and properties of liquids, does not degrade or change its properties in contact with the moving fiber. The finite element method was used to develop the strength properties of the new material. Constitutive equations were defined to relate the state of stress and the state of strain in the material during its work. In the circumferential direction, the Young’s modulus was 790 kPa, and the fiber shape factor was 0.056. In the axial direction, the Young’s modulus was 440 kPa, the fiber shape factor was 0.067. The paper presents the process of optimizing the material model of a new bioprosthesis, which mechanically imitates the natural material of the aorta. A simple fiber structure was immersed in a liquid matrix and described using basic material parameters. This approach allows to obtain a material with non-linear characteristics and high compliance, not seen in previous prostheses made of Dacron.
Early-onset ovarian cancer: a comprehensive analysis
Authors: Horackova Klara , Zemankova Petra , Nehasil Petr , Vocka Michal , Hovhannisyan Milena , Matejkova Katerina , Janatova Marketa , Cerna Marta , Kleiblova Petra , Jelinkova Sandra , Stastna Barbora , Just Pavel , Dolezalova Tatana , Nemcova Barbora , Urbanova Marketa , Koudova Monika , Hazova Jana , Machackova Eva , Foretova Lenka , Stranecky Viktor , Zikan Michal , Kleibl Zdenek , Soukupova Jana 
Published: February 2024

Abstract
The subset of ovarian cancer (OC) diagnosed ≤ 30yo represents a distinct subgroup exhibiting disparities from late-onset OC in many aspects, including indefinite germline cancer predisposition. We performed DNA/RNA whole exome sequencing together with human leukocyte antigen(HLA) typing, polygenic risk score(PRS) assessment and survival analysis in 123 early-onset OC patients compared to histology/stage-matched late-onset and unselected OC patients, and population-matched controls. Only 6/123(4.9%) early-onset OC patients carried a germline pathogenic variant(GPV) in high-penetrance OC predisposition genes, including a single carrier of GPV in BRCA1 and BRCA2 each. Nevertheless, our comprehensive germline analysis of early-onset OC patients revealed two divergent trajectories of potential germline susceptibility. Firstly, overrepresentation analysis highlighted a connection to breast cancer(BC) that was supported by the enrichment of GPV in CHEK2 in early-onset OC(p = 1.2×10− 4), and the presumably BC-specific PRS313, which successfully stratified early-onset OC from controls(p = 0.03). The second avenue pointed towards the impaired immune response, indicated by GPV in LY75-CD302(p = 8.3×10− 4) and coupled with diminished HLA diversity compared with controls(p = 3×10− 7). Furthermore, we found a significantly higher GPV burden in early-onset OC patients compared to controls(p = 3.8×10− 4). We observed survival advantage in early-onset OC patients compared with both age-unselected and histology/stage-matched late-onset OC patients lacking gBRCA1/2. The genetic predisposition to early-onset OC appears to be a heterogeneous and complex process that goes beyond the traditional Mendelian monogenic understanding of hereditary cancer predisposition, with a significant role of the immune system. We speculate that rather a cumulative GPV burden than specific GPV may potentially increase OC risk, concomitantly with reduced HLA diversity.
A Balanced Clustering Mechanism for Routing in Software Defined Wireless Sensor Networks
Authors: Kontagora Nuhu Bello , Muazu Muhammed Bashir , Bello-Salau Habeeb , Adewale Adedokun Emmanuel , Aliyu Ibrahim , Abdulrazaq Muhammed Bashir , Kim Jinsul 
Published: February 2024

Abstract

In conserving energy during routing in Wireless Sensor networks (WSN), Software Define Networking (SDN) was integrated into WSN and referred to as Software Defined Wireless Sensor Network (SDWSN). This is to exclude sensor nodes from routing decisions. Thus, enabling the SDN controller to handle hierarchical routing decisions. The existing WSN hierarchical routing protocols are not adequate for SDWSN due to their unbalanced characteristics in clustering and cluster head selection. In this regard, a Balanced Machine Learning-based Clustering (B-MLC) algorithm is proposed and compared with two closely related hierarchical algorithms (LEACH and FCM) for routing. The outcome indicated that, the B-MLC algorithm maintained a low average packet loss and is efficient in network lifetime elongation, with an average improvement of 60.4% and 89.8% respectively, over LEACH and FCM. Hence, the B-MLC can be adopted in SDWSN for complex monitoring applications.
Efficacy of rituximab and risk factors for poor prognosis in patients with childhood-onset refractory steroid-resistant nephrotic syndrome: a multicenter study
Authors: Yokota Shunsuke , Kamei Koichi , Fujinaga Shuichiro , Hamada Riku , Inaba Aya , Nishi Kentaro , Sato Mai , Ogura Masao , Sakuraya Koji , Ito Shuichi 
Published: February 2024

Abstract
Background
The efficacy of rituximab in refractory steroid-resistant nephrotic syndrome (SRNS) is controversial. We previously reported that rituximab in combination with methylprednisolone pulse therapy (MPT) and immunosuppressants was associated with favorable outcomes. We determined risk factors for poor response following rituximab treatment, which remains unknown.
Methods
This retrospective study included 45 patients with childhood-onset refractory SRNS treated with rituximab treatment across four pediatric kidney facilities. Treatment effects were categorized as complete remission (CR), partial remission (PR), and no remission (NR) at one year after rituximab treatment. Risk factors for poor response (non-CR) were calculated with multivariate logistic regression. Adverse events and the relationship between disease status at one year and long-term prognosis were evaluated.
Results
The rates of CR, PR, and NR at one year were 69%, 24%, and 7%, respectively. The median time from rituximab administration to CR was 90 days. In multivariate analysis, significant risk factors for poor response were the pathologic finding of focal segmental glomerular sclerosis and a long interval between SRNS diagnosis and rituximab administration. The rates of CR were 90.3% and 21.4% in patients receiving rituximab within and after 6 months following SRNS diagnosis, respectively (p < 0.001). Five patients developed chronic kidney disease stage G5, including 2 of the 11 patients with PR and all 3 patients with NR, whereas none of the 31 patients with CR developed chronic kidney disease stage G5.
Conclusions
Early administration of rituximab in combination with MPT and immunosuppressants might achieve favorable outcomes in patients with refractory SRNS.
The Earned Income Tax Credit (EITC) and Time Spent Helping and Caring for Adults
Authors: Strauss Anna Wiersma 
Published: February 2024

Abstract

This is the first study to examine the effect of the Earned Income Tax Credit (EITC) on unpaid caregiving for adults, which could operate through the credit’s effects on labor supply and household income. Using a sample of unmarried mothers and data from the American Time Use Survey (ATUS), I employ a simulated instrument approach to generate causal estimates of the effect of EITC generosity on time use. I find that increases in average EITC benefits have differential effects on caregiving by recipient age. No effect is estimated for the youngest group of unmarried mothers (ages 25–34), who increase employment without reducing time spent assisting adults. In contrast, the oldest group of unmarried mothers (ages 45–54) responds by increasing their propensity to help their parents while maintaining their labor supply. Unmarried mothers aged 35–44 both increase their labor supply and spend more time caregiving for adult family members on the intensive margin, even as they are less likely to assist parents on the extensive margin, especially with chore help. Results for other types of time use (home production, leisure, childcare, education, sleep), as well as probability of multigenerational co-residence, help explain these shifts. For example, for the oldest group of unmarried mothers, increased co-residence with one’s aging parents is estimated to occur and may facilitate this labor-caregiving balance. These results add to a growing body of evidence that the EITC affects recipients’ time allocation beyond paid work and that the effects of the EITC span across generations and households.
Prognostic significance of 68Ga-FAPI-PET/CT in patients with bone metastases in various cancers
Authors: ARAK HACI , Elboga Umut , Cayırlı Yusuf Burak , Aytekin Aydın 
Published: February 2024

Abstract

Objective:This study aimed to compare and18FDGPET/CT in patients who develop bone metastases due to various cancers and to investigate the prognostic significance of the 68FAPI-PET/CT SUVmax value for survival.
Methods:Patients with bone metastases who underwent both 68Ga-FAPI PET/CTand18FDGPET/CT within a 1-week period were included in this retrospective study. The effect of the SUVmax value of bone lesions on overall survival was analyzed.
Results:A total of 75 eligible patients with 139 bone lesions were included in this study. The median age of the patients was 55(30–83) and 48 patients (64%) were newly diagnosed. The primary lesion median 68Ga-FAPI PET/CT SUVmax value was higher than the median 18FDGPET/CT SUVmax (10.75 versus 6.7). Bone lesions 68Ga-FAPI PET/CT SUVmax median(IQR) were 7.8(4.6–13.2), and 18FDGPET/CT SUVmax of bone lesions were 5.9(3.8–8.2). More bone lesions were detected on 68Ga-FAPI PET/CT than on 18FDGPET/CT(median IQR 4 [1–9] versus 2 [1–6](p=0.014). The extra lesions observed on 68Ga-FAPI PET/CT were mostly sclerotic bone lesions(p = 0.001).68Ga-FAPI PET/CT SUVmax was significantly higher in vertebra and thorax lesions(p=0.011 and p=0.018, respectively). While the bone lesion 68Ga-FAPI PET/CT SUVmax affected the OS, the 18FDGPET/CT SUVmax value did not affect the OS (p<0.001 and p=0.079, respectively). In ROC analysis, a cut-off value of 68Ga-FAPI PET/CT SUVmax >7.7 was found for OS(AUC:0.619). The median OS in the group above the cut-off value was worse than that in the group below the cut-off value (32 versus 45) months (p=0.002). In the multivariate analysis for OS, the 68Ga-FAPI PET/CT SUVmax of bone lesions was an important parameter,as well as cancer subtype, ALP level, and disease occurrence.
Conclusions:68Ga-FAPI PET/CT detected more bone lesions and higher SUVmax values than 18FDGPET/CT in various cancers. The prognostic value of the SUVmax value of 68Ga-FAPI PET/CT bone lesions was observed regardless of disease subtype.
Auricular acupressure to improve Oxaliplatin-induced peripheral neuropathy and quality of life: protocol for a randomized controlled trial
Authors: Chang Tsui-Ju , Yeh Mei-Ling , Yeh Albert Lou , Kuo Ashley Lee 
Published: February 2024

Abstract
Purpose
Oxaliplatin-induced peripheral neuropathy (OIPN) is a common adverse effect that worsens with increased drug accumulation, affecting patients’ daily activities and quality of life. This study will evaluate the immediate and carry-over effects of auricular acupressure on chronic (OIPN) symptoms, OIPN pain, and quality of life in patients with colorectal cancer.
Methods
This randomized controlled trial will recruit 76 participants with OIPN. The experimental group will receive auricular acupressure for eight weeks, while the control group will receive standard care. The outcomes will be assessed using an OIPN assessment tool, the Neuropathic Pain Symptom Inventory, a pain visual analogue scale, and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire. Data will be collected before the intervention, biweekly during the intervention, two weeks after the intervention, and one month after the end of the chemotherapy course.
Conclusions
This study will determine the intervention effects of the 8-week auricular acupressure that alleviates OIPN symptoms and pain in patients with colorectal cancer and enhances their quality of life. The protocol design offers a standardized process that can serve as a reference for current and future studies and accumulate clinical experience regarding implementing auricular acupressure interventions.
Multi-View Contextual Adaptation Network for Weakly Supervised Object Detection in Remote Sensing Images
Authors: Ye Binfeng , Zhang Junjie , Rao Yutao , Gao Rui , Zeng Dan 
Published: February 2024

Abstract

Weakly supervised learning plays a pivotal role in the field of object detection, \textit{i.e.} Weakly supervised object detection (WSOD), significantly reducing annotation costs relying on image-level labels. However, WSOD exhibits certain limitations. Typically, they tend to identify the most easily recognizable local regions within targets, posing challenges in accurately delineating the boundaries of targets. Moreover, the presence of multiple instances of the same class in adjacent locations complicates the effective distinction between multiple objects within the same category. On the other hand, the complex backgrounds and dense distribution of targets in remote sensing images (RSI) further exacerbate the difficulty of weakly supervised detection.To address the above issues, we propose a model termed the Multi-View Contextual Adaptation Network (VCANet). Building on the classic Online Instance Classifier Refinement (OICR) framework, we propose to incorporate an contextual adaptation perception, within a multi-view learning framework, and integrate a pseudo-label filtering process. The contextual adaptation perception utilizes the surrounding environment information to enhance localization capabilities, guiding the model to prioritize target objects by referring to their spatially neighboring pixels. Multi-view learning manufactures additional constraints from diverse perspectives, thereby revealing objects that might be overlooked due to the weak supervision in a single view. The pseudo-label filtering process eliminates inaccurate pseudo-labels by identifying reliable foregrounds to mitigate overlapping proposals during the label propagation. On challenging datasets NWPU VHR-10.v2 and DIOR, we achieve promising results with mAP of 62.3% and 28.2%, respectively, surpassing existing benchmarks. We will make our code publicly available upon the acceptance of our paper.
A Retrospective Study on the Effect of Low Dose Atropine (0.01%) as Standalone and Combination Treatment in Management of Patients With Ciliary Muscle Spasm
Authors: Lau Christine , Azmi Azam N.H. , Ramasamy Sunder 
Published: February 2024

Abstract
Purpose - The aim of this retrospective study was to evaluate the efficacy of low dose atropine in reducing the symptoms of ciliary muscle spasm patients. This study obtained ethical approval letters and reviewed medical files at Thomson Hospital Kota Damansara.
Methods - Subjects in the age range between 13 and 40 years old regardless gender and race, and who have been diagnosed with ciliary spasm and was prescribed with low dose atropine as management were enrolled in this study. Relevant data such as demographic background of the subjects, their refraction results and reported symptoms were collected to be analysed. Subjects who had ciliary muscle spasm with other ocular diseases, and who did not return for follow-up within 3 months were excluded from this study.
Results- A total of 36 symptomatic ciliary muscle spasm subjects with their mean age of 27.19 ± 7.31 years were analysed. Majority of them (47.2%, n=17) were prescribed with Atropine 0.01%, 27.8% (n=10) were given combination of Atropine 0.01% with Phenylephrine 2.5% or 10% and Tropicamide 1%, 22.2% (n=8) were given Atropine 0.01% with anti-fatigue lenses, and 2.8% (n=1) were given Atropine 0.01% with combination of Phenylephrine and Tropicamide, and anti-fatigue lenses as the treatment options for the patients. Among 22 patients, almost 47.2% (n=17) reported symptoms completely resolved, while 13.9% (n=5) had their symptoms not completely resolved. Further analysis using Pearson’s chi-square test showed no significant difference in term of success rate between the 4 treatment options.
Conclusion - This study showed that prescription Atropine 0.01%, either as a standalone treatment or with other combination treatment did alleviate the symptoms of ciliary muscle spasm.
Safety helmet wearing detection algorithm based on DSM-YOLO
Authors: Zhang Jing , Feng Yingying , Li Xu , Lang Ding , Xu Yuguang , Li Hong-an , Li Xuewen 
Published: February 2024

Abstract
Safety helmets can effectively prevent miners from accidental head injuries, reduce accident rates during coal mine, and safety helmet-wearing detection is of great significance to the safety management of coal mine, and is an important component of video surveillance systems. This paper proposes a new safety helmet-wearing detection algorithm called Depthwise Separable Multi-factor YOLO (DSM-YOLO). First, the algorithm uses Depthwise Separable Convolution(DSConv) to reduce the number of parameters, deepens the extraction of deep feature information, speed up feature transfer in the model, and improves the speed of helmet detection. Second, in order to make a better match between the predicted box of the target and the corresponding ground truth box, a multi-factor loss function is introduced, and the multi-factor loss function simultaneously takes into account the intersection ratio loss, distance loss, aspect ratio loss, and angle perception loss, which improves the accuracy of helmet detection. The results of the experiments showed that the inference speed of the algorithm is 62.5 Frames/s, which is 19.0 Frames/s faster than the YOLOv7 algorithm; the average precision is 95.1%, which is 3.4% higher than the YOLOv7 algorithm, meeting the real-time detection requirements for safety helmet wearing in coal mine.
To evaluate the performance of simultaneous amplification and testing assay for group B Streptococcus detection: comparison with real-time PCR and ddPCR assays
Authors: Lu LOUKAIYI , Chen Yisheng , Wang Qiang , Gao Jing , Ying Chunmei 
Published: February 2024

Abstract

Background
To evaluate the performance of simultaneous amplification and testing (SAT) assay for the detection of group B Streptococcus (GBS) in maternal vaginal and perianal swabs compared with real-time polymerase chain reaction (RT‒PCR).
Methods
We obtained vaginal and perianal swabs from 1474 pregnant women at the Obstetrics and Gynecology Hospital of Fudan University (Shanghai, China) between April 2023 and June 2023. Vaginal and perianal swabs were collected at 35–37 weeks of gestation. Swabs were tested for GBS simultaneously by using the SAT assay and RT‒PCR, and a comparative analysis (kappa coefficient) was performed. Furthermore, we conducted additional droplet digital PCR (ddPCR) tests to confirm the results when there were controversial results between SAT and RT‒PCR. In addition, we compared the limit of detection, technical specificity, repeatability and reproducibility of SAT-GBS with those of routine RT‒PCR assays.
Results
In our study, the rate of clinical GBS colonization according to the SAT assay was 11.5% (169/1471). The SAT assay showed a sensitivity of 91.8%, a specificity of 99.9%, a diagnostic accuracy of 98.9%, a positive predictive value (PPV) of 99.4% and a negative predictive value (NPV) of 98.8%. The kappa value between RT‒PCR and SAT was 0.917.
Conclusions
This SAT assay for the detection of group B Streptococcus is not only easy to perform but can also detect GBS sensitively and specifically and may be used in the regular molecular diagnosis of GBS in cases of newborn sepsis and meningitis.
Research on Identification of Metal Fittings in Transmission Lines Based on Improved RetinaNet
Authors: Liu Chuanyang , Liu Jingjing , Lin Yujuan , Wu Yiquan , Sun Zuo 
Published: February 2024

Abstract
As an indispensable part of transmission lines, metal fittings play an important role in the safe and stable operation of power system. Automatic detection of metal fittings in the aerial images of power inspection is an urgent problem to be solved. In this study, a deep learning method is proposed to perform metal fittings detection in UAV-based images. Firstly, metal fittings data set used for targets detection is created, including Damper, XC Clamp, and NZ Clamp. Secondly, a new deep learning model is proposed for metal fittings detection. To further improve the accuracy of metal fittings identification in aerial images, ResNet50, attention mechanism, BiFPN and Focal loss are adopted to improve RetinaNet model. Finally, the proposed model and comparative models are trained and tested on metal fittings data set. Experimental results show that the proposed model has a good effect on metal fittings detection in aerial images from power inspection. More importantly, the mAP of the proposed model can reach 93.22%, which is 7%, 9.5%, 16%, and 0.4% higher than that of original RetinaNet, Faster R-CNN, SSD and YOLOv7, respectively. And the AP values of Damper, XC Clamp and NZ Clamp detection can reach 99%, 96%, and 85% by the proposed model. In addition, compared with the mainstream target detection models, the proposed model can obtain better performance in the detection of metal fittings with complex backgrounds and small targets.