bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards higher-order calculations of quarkonia production with $$k_T$$-factorization: P-wave charmonia
Authors: Baranov S. P. , Lipatov A. V. , Prokhorov A. A. , Chen X. 
Published: April 2024

AbstractInclusive P-wave charmonia production in hadronic collisions at high energies is discussed in the framework of non-relativistic QCD and $$k_T$$

k
T

-factorization formalism. We present two consistent approaches to merge the usual leading order $$k_T$$

k
T

-factorization calculations with tree-level next-to-leading order off-shell amplitudes. Using these prescriptions, we extracted long-distance matrix elements for $$\chi _c$$

χ
c

mesons from a combined fit to available Tevatron and LHC data. In contrast to previous (leading order) calculations, our fits do not rule out the equalness of the color singlet wave functions of $$\chi _{c1}$$

χ

c
1

and $$\chi _{c2}$$

χ

c
2

states. The extracted values of long-distance matrix elements are employed to analyse the $$\chi _c$$

χ
c

polarization data reported recently by the CMS Collaboration. Our predictions are in a reasonably good agreement with the Tevatron and LHC measurements within the theoretical and experimental uncertainties.
Stability of Cauchy horizon in charged black holes surrounded by quintessential dark energy
Authors: Chen Lu , Tan Jia 
Published: April 2024

AbstractBy investigating the Quasinormal Modes of a massless neutral scalar field, we have explored the influence of dark energy on the strong cosmic censorship (SCC) of charged de Sitter-like black holes. The results indicate that SCC can consistently be violated as long as the black hole approaches extremality. However, as the state parameter $$\sigma = 3\omega _f + 1$$

σ
=
3

ω
f

+
1

of the dark energy increases and approaches zero, the width of SCC violation interval demonstrates an overall decreasing trend, converging towards zero. Specifically, our research has identified a critical state parameter $$\sigma _{\text {crt}}$$

σ
crt

for dark matter. Beyond this critical value, enhancing the state parameter effectively mitigates SCC violations. However, at this critical threshold, the width of the violation interval stabilizes or marginally increase. These findings reveal a nuanced relationship between the asymptotic properties of black holes and the validity of the SCC, offering profound insights into potential mechanisms governing both the occurrence and alleviation of SCC violations.
MFAP4-Deficiency Aggravates Age-Induced Changes in Resistance Artery Structure, While Ameliorating Hypertension
Authors: Christensen Kimmie B. , Ünsal Şeyda , Ebbesen Morten F. , Hemstra Line , Schlosser Anders , Rosenstand Kristoffer , Hansen Pernille B.L. , Jensen Boye L. , Bloksgaard Maria , Simonsen Ulf , Sorensen Grith L. 
Published: April 2024

BACKGROUND:
Abnormalities of resistance arteries may play essential roles in the pathophysiology of aging and hypertension. Deficiency of the vascular extracellular matrix protein MFAP4 (microfibrillar-associated protein 4) has previously been observed as protective against aberrant arterial remodeling. We hypothesized that MFAP4-deficiency would reduce age- and hypertension-dependent arterial changes in extracellular matrix composition and stiffening.

METHODS:

Mesenteric arteries were isolated from old (20–23 months) littermate
Mfap4

+/+

and
Mfap4

−/−

mice, and 2-photon excitation microscopy imaging was used to quantify elastin and collagen volumes and dimensions in the vascular wall.

Ten-week-old littermate
Mfap4

+/+

and
Mfap4

−/−

mice were subjected to 20 days of continuous Ang II (angiotensin II) infusion and hypertension was monitored using invasive blood pressure measurements. Arterial stiffness, responses to vascular constrictors, and myogenic tone were monitored using wire- or pressure-myography. Collagen contents were assessed by Western blotting.

RESULTS:

MFAP4-deficiency significantly increased collagen volume and elastin fragmentation in aged mesenteric arteries without affecting arterial stiffness. MFAP4-deficient mice exhibited reduced diastolic pressure in Ang II-induced hypertension. There was no significant effect of MFAP4-deficiency on mesenteric artery structural remodeling or myogenic tone, although collagen content in mesenteric arteries was tendentially increased in hypertensive
Mfap4

+/+

mice relative to
Mfap4

−/−

mice. Increased efficacy of vasoconstrictors (phenylephrine, thromboxane) and reduced stiffness were observed in Ang II-treated
Mfap4

−/−

mouse mesenteric arteries in ex vivo myography recordings.

CONCLUSIONS:
MFAP4-deficiency reduces the elastin/collagen ratio in the aging resistance artery without affecting arterial stiffness. In contrast, MFAP4-deficiency reduces the stiffness of resistance arteries and ameliorates Ang II-induced hypertension.
The impact of cytotoxic therapy on the risk of progression and death in clonal cytopenia(s) of undetermined significance
Authors: Li Marissa , Baranwal Anmol , Gurney Mark , Shah Syed N. , Al-Kali Aref , Alkhateeb Hassan , Foran James , Arana Yi Cecilia , Ongie Laura , Chen Dong , Mangaonkar Abhishek , McCullough Kristen , Tefferi Ayalew , Lasho Terra , Finke Christy , Patnaik Mrinal M. , Shah Mithun Vinod 
Published: April 2024

Abstract
Clonal cytopenia of undetermined significance (CCUS) is defined by a myeloid driver mutation in the context of otherwise unexplained cytopenia. CCUS has an inherent risk of progressing to myeloid neoplasm. However, it is unknown how exposure to previous cytotoxic therapy may impact the risk of progression and survival. We stratified patients with CCUS by prior exposure to DNA-damaging therapy. Of 151 patients, 46 (30%) had received cytotoxic therapy and were classified as therapy-related CCUS (t-CCUS), whereas 105 (70%) had de novo CCUS. A lower proportion of t-CCUS had hypercellular marrows (17.8% vs 44.8%, P = .002) but had higher median bone marrow blast percentages. After a median follow-up of 2.2 years, t-CCUS had significantly shorter progression-free survival (PFS, 1.8 vs 6.3 years; hazard ratio [HR], 2.1; P = .007) and median overall survival (OS; 3.6 years vs not reached; HR, 2.3; P = .007) compared with CCUS. Univariable and multivariable time-to-event analyses showed that exposure to cytotoxic therapy independently accounted for inferior PFS and OS. Despite the similarities in clinical presentation between CCUS and t-CCUS, we show that exposure to prior cytotoxic therapies was an independent risk factor for inferior outcomes. This suggests that t-CCUS represents a unique clinical entity that needs more stringent monitoring or earlier intervention strategies.
Elucidating the ecophysiology of soybean pod-sucking stinkbug Riptortus pedestris (Hemiptera: Alydidae) based on de novo genome assembly and transcriptome analysis
Authors: Li Chade , Nong Wenyan , Boncan Delbert Almerick T. , So Wai Lok , Yip Ho Yin , Swale Thomas , Jia Qi , Vicentin Ignacio G. , Chung Gyuhwa , Bendena William G. , Ngo Jacky C. K. , Chan Ting Fung , Lam Hon-Ming , Hui Jerome H. L. 
Published: April 2024

AbstractFood security is important for the ever-growing global population. Soybean, Glycine max (L.) Merr., is cultivated worldwide providing a key source of food, protein and oil. Hence, it is imperative to maintain or to increase its yield under different conditions including challenges caused by abiotic and biotic stresses. In recent years, the soybean pod-sucking stinkbug Riptortus pedestris has emerged as an important agricultural insect pest in East, South and Southeast Asia. Here, we present a genomics resource for R. pedestris including its genome assembly, messenger RNA (mRNA) and microRNA (miRNA) transcriptomes at different developmental stages and from different organs. As insect hormone biosynthesis genes (genes involved in metamorphosis) and their regulators such as miRNAs are potential targets for pest control, we analyzed the sesquiterpenoid (juvenile) and ecdysteroid (molting) hormone biosynthesis pathway genes including their miRNAs and relevant neuropeptides. Temporal gene expression changes of these insect hormone biosynthesis pathways were observed at different developmental stages. Similarly, a diet-specific response in gene expression was also observed in both head and salivary glands. Furthermore, we observed that microRNAs (bantam, miR-14, miR-316, and miR-263) of R. pedestris fed with different types of soybeans were differentially expressed in the salivary glands indicating a diet-specific response. Interestingly, the opposite arms of miR-281 (-5p and -3p), a miRNA involved in regulating development, were predicted to target Hmgs genes of R. pedestris and soybean, respectively. These observations among others highlight stinkbug’s responses as a function of its interaction with soybean. In brief, the results of this study not only present salient findings that could be of potential use in pest management and mitigation but also provide an invaluable resource for R. pedestris as an insect model to facilitate studies on plant-pest interactions.
Staphylococcus aureus foldase PrsA contributes to the folding and secretion of protein A
Authors: Lin Mei-Hui , Liu Chao-Chin , Lu Chiao-Wen , Shu Jwu-Ching 
Published: April 2024

Abstract
Background
Staphylococcus aureus secretes a variety of proteins including virulence factors that cause diseases. PrsA, encoded by many Gram-positive bacteria, is a membrane-anchored lipoprotein that functions as a foldase to assist in post-translocational folding and helps maintain the stability of secreted proteins. Our earlier proteomic studies found that PrsA is required for the secretion of protein A, an immunoglobulin-binding protein that contributes to host immune evasion. This study aims to investigate how PrsA influences protein A secretion.

Results
We found that in comparison with the parental strain HG001, the prsA-deletion mutant HG001ΔprsA secreted less protein A. Deleting prsA also decreased the stability of exported protein A. Pulldown assays indicated that PrsA interacts with protein A in vivo. The domains in PrsA that interact with protein A are mapped to both the N- and C-terminal regions (NC domains). Additionally, the NC domains are essential for promoting PrsA dimerization. Furthermore, an immunoglobulin-binding assay revealed that, compared to the parental strain HG001, fewer immunoglobulins bound to the surface of the mutant strain HG001ΔprsA.

Conclusions
This study demonstrates that PrsA is critical for the folding and secretion of protein A. The information derived from this study provides a better understanding of virulent protein export pathways that are crucial to the pathogenicity of S. aureus.
Sedation versus general anesthesia on all-cause mortality in patients undergoing percutaneous procedures: a systematic review and meta-analysis
Authors: Su Xuesen , Zhao Zixin , Zhang Wenjie , Tian Yihe , Wang Xin , Yuan Xin , Tian Shouyuan 
Published: April 2024

Abstract
Background
The comparison between sedation and general anesthesia (GA) in terms of all-cause mortality remains a subject of ongoing debate. The primary objective of our study was to investigate the impact of GA and sedation on all-cause mortality in order to provide clarity on this controversial topic.

Methods
A systematic review and meta-analysis were conducted, incorporating cohort studies and RCTs about postoperative all-cause mortality. Comprehensive searches were performed in the PubMed, EMBASE, and Cochrane Library databases, with the search period extending until February 28, 2023. Two independent reviewers extracted the relevant information, including the number of deaths, survivals, and risk effect values at various time points following surgery, and these data were subsequently pooled and analyzed using a random effects model.

Results
A total of 58 studies were included in the analysis, with a majority focusing on endovascular surgery. The findings of our analysis indicated that, overall, and in most subgroup analyses, sedation exhibited superiority over GA in terms of in-hospital and 30-day mortality. However, no significant difference was observed in subgroup analyses specific to cerebrovascular surgery. About 90-day mortality, the majority of studies centered around cerebrovascular surgery. Although the overall pooled results showed a difference between sedation and GA, no distinction was observed between the pooled ORs and the subgroup analyses based on RCTs and matched cohort studies. For one-year all-cause mortality, all included studies focused on cardiac and macrovascular surgery. No difference was found between the HRs and the results derived from RCTs and matched cohort studies.

Conclusions
The results suggested a potential superiority of sedation over GA, particularly in the context of cardiac and macrovascular surgery, mitigating the risk of in-hospital and 30-day death. However, for the longer postoperative periods, this difference remains uncertain.

Trial registration
PROSPERO CRD42023399151; registered 24 February 2023.
Treatment patterns and persistence on disease modifying therapies for multiple sclerosis and its associated factors
Authors: Cárdenas-Robledo Simón , Arenas-Vargas Laura Estefanía , Arenas Rubén Darío , Gaspar-Toro Jorge Mario , Muñoz-Rosero Ángela María , Tafur-Borrero Aranza Helena , Marín-Medina Daniel Stiven , Acosta-Fajardo Hernan Andrés , Guío-Sánchez Claudia , López-Reyes Lorena 
Published: April 2024

Abstract
Background
Effective interventions for Multiple Sclerosis require timely treatment optimization which usually involves switching disease modifying therapies. The patterns of prescription and the reasons for changing treatment in people with MS, especially in low prevalence populations, are unknown.

Objectives
To describe the persistence, reasons of DMT switches and prescription patterns in a cohort of Colombian people with MS.

Methods
We conducted a retrospective observational study including patients with confirmed MS with at least one visit at our centre. We estimated the overall incidence rate of medication changes and assessed the persistence on medication with Kaplan–Meier survival estimates for individual medications and according to efficacy and mode of administration. The factors associated with changing medications were assessed using adjusted Cox proportional-hazards models. The reasons for switching medication changes were described, and the prescription patterns were assessed using network analysis, with measures of centrality.

Results
Seven hundred one patients with MS were included. Mean age was 44.3 years, and 67.9% were female. Mean disease duration was 11.3 years and 84.5% had relapsing MS at onset, with median EDSS of 1.0. Treatment was started in 659 (94%) of the patients after a mean of 3 years after MS symptom onset. Among them, 39.5% maintained their initial DMT, 29.9% experienced a single DMT change, while 18.7% went through two, and 11.9% had three or more DMT changes until the final follow-up. The total number of treatment modifications reached 720, resulting in an incidence rate of 1.09 (95% confidence interval: 1.01–1.17) per patient per year The median time to change after the first DMT was 3.75 years, and was not different according to the mode of administration or efficacy classification. The main reasons for changing DMT were MS activity (relapses, 56.7%; MRI activity, 18.6%), followed by non-serious adverse events (15.3%) and disability (11.1%). Younger age at MS onset, care under our centre and insurer status were the main determinants of treatment change. Network analysis showed that interferons and fingolimod were the most influential DMTs.

Conclusions
A majority of patients switch medications, mostly due to disease activity, and in association with age and insurer status.
Migraine treatment: quo vadis? Real-world data study (2015–2022) in Spain
Authors: Pozo-Rosich Patricia , Carmo Mafalda , Muñiz Alejandro , Armada Beatriz , Moya-Alarcón Carlota , Pascual Julio 
Published: April 2024

Abstract
Background
Migraine is a leading cause of disability, estimated to affect one-in-ten people in Spain. This study aimed to describe the management of migraine in Spain and identify improvement areas.

Methods
Non-interventional, retrospective, cross-sectional cohort study conducted using an electronic medical records database covering visits to public healthcare providers for 3% of the Spanish population. Patients with a migraine diagnosis (ICD-9 346) between 01/2015 and 04/2022 were included, as well as their demographic and clinical characteristics, prescribed migraine treatments and the specialty of the prescribing physicians.

Results
The database included 61,204 patients diagnosed with migraine. A migraine treatment had been prescribed to 50.6% of patients over the last 24 months (only acute to 69.5%, both acute and preventive to 24.2%, and only preventive to 6.3%). The most frequently prescribed treatments were NSAIDs (56.3%), triptans (44.1%) and analgesics (28.9%). Antidepressants were the most common preventive treatment (prescribed to 17.9% of all treated patients and 58.7% of those treated with a preventive medication), and anti-CGRP monoclonal antibodies the least prescribed (1.7%; 5.7%). In 13.4% of cases, preventive medications were the first treatment: alone in 5.8% of cases and together with an acute medication in 7.6%. A fifth of patients who were initially prescribed with only acute treatment were later prescribed a preventive medication (20.7%). On average, it took 29.4 months for this change to occur. Two-thirds of patients started their preventive treatment in primary care (64.2%). The percentage of patients treated by a neurologist increased with the number of received preventive medications. However, 28.8% of patients who had already been prescribed five or more distinct preventive treatments were not treated by a neurologist. Migraine patients had between 1.2- and 2.2-times higher prevalence of comorbidities than the general population, age-gender adjusted.

Conclusions
Our study emphasizes the need for improved management of migraine in Spain to reduce the risk of chronification and improve patient outcomes. More training and coordination across healthcare professionals is necessary to recognize and address risk factors for migraine progression, including multiple associated comorbidities and several lines of treatment, and to provide personalized treatment plans that address the complex nature of the condition.
Recreating the village: the patient experience with a hybrid model of Group Perinatal Care (GPPC) in an academic family health team
Authors: Biringer Anne , Morson Natalie , Walji Sakina , Tregaskiss Natalie , Merritt Susannah , Makuwaza Tutsirai , Forte Milena 
Published: April 2024

Abstract
Background
Group prenatal care (GPC) has been shown to have a positive impact on social support, patient knowledge and preparedness for birth. We developed an interprofessional hybrid model of care whereby the group perinatal care (GPPC) component was co-facilitated by midwives (MW) and family medicine residents (FMR) and alternating individual visits were provided by family physicians (FP’s) within our academic family health team (FHT) In this qualitative study, we sought to explore the impact of this program and how it supports patients through pregnancy and the early newborn period.

Methods
Qualitative study that was conducted using semi-structured telephone interviews with 18 participants who had completed GPPC in the Mount Sinai Academic Family Health Team in Toronto, Canada and delivered between November 2016 and October 2018. Interviews were audio-recorded and transcribed verbatim. Thematic analysis was conducted by team members using grounded theory.

Results
Four over-arching themes emerged from the data: (i) Participants highly valued information they received from multiple trusted sources, (ii) Participants felt well cared for by the collaborative and coordinated interprofessional team, (iii) The design of GPPC enabled a shared experience, allowing for increased support of the pregnant person, and (iv) GPPC facilitated a supportive transition into the community which positively impacted participants’ emotional well- being.

Conclusions
The four constructs of social support (emotional, informational, instrumental and appraisal) were central to the value that participants found in GPPC. This support from the team of healthcare providers, peers and partners had a positive impact on participants’ mental health and helped them face the challenges of their transition to parenthood.
Population-based BRCA germline mutation screening in the Han Chinese identifies individuals at risk of BRCA mutation-related cancer: experience from a clinical diagnostic center from greater Shanghai area
Authors: Wu Zhiyuan , Zhang Qingyun , Jin Yiting , Zhang Xinju , Chen Yanli , Yang Can , Tang Xuemei , Jiang Haowen , Wang Xiaoyi , Zhou Xinli , Yu Feng , Wang Bing , Guan Ming 
Published: April 2024

Abstract
Background
Deleterious BRCA1/2 (BRCA) mutation raises the risk for BRCA mutation-related malignancies, including breast, ovarian, prostate, and pancreatic cancer. Germline variation of BRCA exhibits substantial ethnical diversity. However, there is limited research on the Chinese Han population, constraining the development of strategies for BRCA mutation screening in this large ethnic group.

Methods
We profile the BRCA mutational spectrum, including single nucleotide variation, insertion/deletion, and large genomic rearrangements in 2,080 apparently healthy Chinese Han individuals and 522 patients with BRCA mutation-related cancer, to determine the BRCA genetic background of the Chinese Han population, especially of the East Han. Incident cancer events were monitored in 1,005 participants from the healthy group, comprising 11 BRCA pathogenic/likely pathogenic (PLP) variant carriers and 994 PLP-free individuals, including 3 LGR carriers.

Results
Healthy Chinese Han individuals demonstrated a distinct BRCA mutational spectrum compared to cancer patients, with a 0.53% (1 in 189) prevalence of pathogenic/likely pathogenic (PLP) variant, alongside a 3 in 2,080 occurrence of LGR. BRCA1 c. 5470_5477del demonstrated high prevalence (0.44%) in the North Han Chinese and penetrance for breast cancer. None of the 3 LGR carriers developed cancer during the follow-up. We calculated a relative risk of 135.55 (95% CI 25.07 to 732.88) for the development of BRCA mutation-related cancers in the BRCA PLP variant carriers (mean age 42.91 years, median follow-up 10 months) compared to PLP-free individuals (mean age 48.47 years, median follow-up 16 months).

Conclusion
The unique BRCA mutational profile in the Chinese Han highlights the potential for standardized population-based BRCA variant screening to enhance BRCA mutation-related cancer prevention and treatment.