bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compulsive shopping behavior and disvalues
Authors: Piper Luigi , de Cosmo Lucrezia Maria , Guido Gianluigi 
Published: April 2024

AbstractThe aim of this study is to analyze whether disvalues—that is, undesirable traits and emotions that have a negative impact on the individual and are reflected in the Seven Deadly Sins (anger, envy, gluttony, greed, lust, pride, and sloth) and the Dark Triad traits (narcissism, machiavellianism, and psychopathy)—have a predictive power for pathological and uncontrollable shopping behavior (compulsive shopping). Two studies were conducted on as many consumer samples to examine the relationship between disvalues and compulsive shopping behavior and the influence of personality traits on this relationship. The results of Study 1 confirmed that anger, envy, gluttony, and pride, as well as psychopathy directly influence compulsive shopping behavior. In addition, two types of consumers were identified: those who are guided by values (Sober and Light consumers) and those who are guided by disvalues (Vicious and Dark consumers). Only the latter exhibit a high levels of compulsive shopping behavior. Study 2 found that personality traits (in terms of the Big Five factors) moderate the relationship between disvalues and compulsive shopping behavior. More specifically, this relationship is negatively moderated by conscientiousness and agreeableness, and positively moderated by neuroticism.
Flavonoids From the Aerial Parts of Sophora tonkinensis and Their Potential Anti‐Inflammatory Activities
Authors: Yang Qing‐Qing , Yang Yan‐Fei , Chen Xuan‐Qin , Li Rong‐Tao , Zhang Zhi‐Jun 
Published: April 2024

AbstractFour undescribed prenylated flavonoids, sophoratones A–D (1–4), and 17 known flavonoids, were obtained from the aerial parts of Sophora tonkinensis. Their structures with absolute configurations were elucidated by detailed interpretation of NMR spectroscopy, mass spectrometry, and ECD calculations. Meanwhile, the ability of these compounds to inhibit the release of nitric oxide (NO) by a lipopolysaccharide induced mouse in RAW 264.7 cells was assayed. The results indicated that some compounds exhibited clear inhibitory effects, with IC50 ranging from 19.91±1.08 to 35.72±2.92 μM. These results suggest that prenylated flavonoids from the aerial parts of S. tonkinensis could potentially be used as a latent source of anti‐inflammatory agents.
Using Förster Resonance Energy Transfer (FRET) to Understand the Ubiquitination Landscape
Authors: Gill Jashanjot Kaur , Shaw Gary S. 
Published: April 2024

AbstractFörster resonance energy transfer (FRET) is a fluorescence technique that allows quantitative measurement of protein interactions, kinetics and dynamics. This review covers the use of FRET to study the structures and mechanisms of ubiquitination and related proteins. We survey FRET assays that have been developed where donor and acceptor fluorophores are placed on E1, E2 or E3 enzymes and ubiquitin (Ub) to monitor steady‐state and real‐time transfer of Ub through the ubiquitination cascade. Specialized FRET probes placed on Ub and Ub‐like proteins have been developed to monitor Ub removal by deubiquitinating enzymes (DUBs) that result in a loss of a FRET signal upon cleavage of the FRET probes. FRET has also been used to understand conformational changes in large complexes such as multimeric E3 ligases and the proteasome, frequently using sophisticated single molecule methods. Overall, FRET is a powerful tool to help unravel the intricacies of the complex ubiquitination system.
Detection the quality of pumpkin seeds based on terahertz coupled with convolutional neural network
Authors: Sun Zhaoxiang , Li Bin , Yang Akun , Liu Yande 
Published: April 2024

AbstractPumpkin seeds are nutritious and have some medicinal value. However, the mold and sprouting are produced during the storage of pumpkin seeds. Food safety and quality problems may be caused if they are not removed in time for processing. The traditional testing methods are cumbersome to operate, complex, and destructive in sample preparation. Therefore, terahertz time‐domain spectroscopy (THz‐TDS) technology was proposed to achieve the detection of the internal quality of pumpkin seeds. Firstly, samples of pumpkin seeds of different qualities were crafted, and they were moldy for 3 days, moldy for 6 days, sprouted and moldy, sprouted and normal pumpkin seeds, respectively. Then, the pumpkin seeds of different qualities were dried, ground, and pressed, and their spectral data were collected. The terahertz spectra of the five types of samples were significantly different. The support vector machine (SVM), random forest (RF), and convolutional neural network (CNN) qualitative discriminant models were established with the raw absorbance spectral data, the preprocessed absorbance spectral data, and the preprocessed and band‐screened absorbance spectral data, respectively, where the CNN model based on the raw spectral data has the highest classification accuracy of 96%. The CNN models do not require advance spectral data processing, simplifying the spectral analysis process. And it achieves best classification results in the accuracy of detection compared to traditional chemometric models. The CNN combined with THz‐TDS method has great potential for application in the detection of agricultural products. It provides a new detection method for the field of quality detection of agricultural products.
Novel Types of Phyllobilins in a Fern ‐ Molecular Reporters of the Evolution of Chlorophyll Breakdown in the Paleozoic Era
Authors: Erhart Theresia , Nadegger Christian , Vergeiner Stefan , Kreutz Christoph , Müller Thomas , Kräutler Bernhard 
Published: April 2024

AbstractBreakdown of chlorophyll (Chl), as studied in angiosperms, follows the pheophorbide a oxygenase/phyllobilin (PaO/PB) pathway, furnishing linear tetrapyrroles, named phyllobilins (PBs). In an investigation with fern leaves we have discovered iso‐phyllobilanones (iPBs) with an intriguingly rearranged and oxidized carbon skeleton. We report here a key second group of iPBs from the fern and on their structure analysis. Previously, these additional Chl‐catabolites escaped their characterization, since they exist in aqueous media as mixtures of equilibrating isomers. However, their chemical dehydration furnished stable iPB‐derivatives that allowed the delineation of the enigmatic structures and chemistry of the original natural catabolites. The structures of all fern‐iPBs reflect the early core steps of a PaO/PB‐type pathway and the PB‐to‐iPB carbon skeleton rearrangement. A striking further degradative chemical ring‐cleavage was observed, proposed to consume singlet molecular oxygen (1O2). Hence, Chl‐catabolites may play a novel active role in detoxifying cellular 1O2. The critical deviations from the PaO/PB pathway, found in the fern, reflect evolutionary developments of Chl‐breakdown in the green plants in the Paleozoic era.
PROTOCOL: The efficacy of nutritional interventions in reducing childhood/youth aggressive and antisocial behavior: A systematic review and meta‐analysis
Authors: Konkolÿ Thege Barna , Kinzel Eden , Hartmann‐Boyce Jamie , Choy Olivia 
Published: April 2024

AbstractThis is a protocol for a Campbell systematic review of intervention effectiveness. The goal of this systematic review is to answer the following questions based on the available empirical evidence: Are there nutritional interventions (dietary manipulation, fortification or supplementation) that can reduce excessive aggression towards others in children/youth? If yes, how strong is their effect and is there a difference among the three intervention types? Are there nutritional interventions that can reduce antisocial behaviors in children/youth? If yes, how strong is their effect and is there a difference among the intervention types? Are there nutritional interventions that can reduce violent offending in children/youth? If yes, how strong is their effect and is there a difference among the intervention types? Are there nutritional interventions that can reduce non‐violent offending in children/youth? If yes, how strong is their effect and is there a difference among the intervention types? What implementation barriers and solutions to these exist in relation to the above nutritional interventions in children/youth?
Incidence of chemotherapy‐related cardiac dysfunction in cancer patients
Authors: Deng Hai‐Wei , Fan Rui , Zhai Yuan‐Sheng , Li Jie , Huang Zhi‐Bin , Peng Long‐Yun 
Published: April 2024

AbstractBackgroundCancer patients are increasingly affected by chemotherapy‐related cardiac dysfunction. The reported incidence of this condition vary significantly across different studies.HypothesisA better comprehensive understanding of chemotherapy‐related cardiac dysfunction incidence in cancer patients is imperative. Therefore, we performed a meta‐analysis to establish the overall incidence of chemotherapy‐related cardiac dysfunction in cancer patients.MethodsWe searched articles in PubMed and EMBASE from database inception to May 1, 2023. Studies that reported the incidence of chemotherapy‐related cardiac dysfunction in cancer patients were included.ResultsA total of 53 studies involving 35 651 individuals were finally included in the meta‐analysis. The overall pooled incidence of chemotherapy‐related cardiac dysfunction in cancer patients was 63.21 per 1000 person‐years (95% CI: 57.28−69.14). The chemotherapy‐related cardiac dysfunction incidence increased steeply within half a year of cancer chemotherapy. Also, the trend of chemotherapy‐related cardiac dysfunction incidence appeared to have plateaued after a longer duration of follow‐up. In addition, chemotherapy‐related cardiac dysfunction incidence rates are significantly higher among patients with age ≥50 years versus patients with age <50 years (99.96 vs. 34.48 per 1000 person‐years). The incidence rate of cardiac dysfunction was higher among breast cancer patients (72.97 per 1000 person‐years), leukemia patients (65.21 per 1000 person‐years), and lymphoma patients (55.43 per 1000 person‐years).ConclusionOur meta‐analysis unveiled a definitive overall incidence rate of chemotherapy‐related cardiac dysfunction in cancer patients. In addition, it was found that the risk of developing this condition escalates within the initial 6 months postchemotherapy, subsequently tapering off to become statistically insignificant after a duration of 6 years.
Structure and Activity of Reconstructed Pseudo‐Ancestral Cyclotides
Authors: Jiang Zhihao , Huang Yen‐Hua , Kaas Quentin , Craik David J. , Wang Conan K. 
Published: April 2024

AbstractCyclotides are cyclic peptides that are promising scaffolds for the design of drug candidates and chemical tools. However, despite there being hundreds of reported cyclotides, drug design studies have commonly focussed on a select few prototypic examples. Here, we explored whether ancestral sequence reconstruction could be used to generate new cyclotides for further optimization. We show that the reconstructed ‘pseudo‐ancestral’ sequences, named Ancy‐m (for the ancestral cyclotide of the Möbius sub‐family) and Ancy‐b (for the bracelet sub‐family), have well‐defined structures like their extant members, comprising the core structural feature of a cyclic cystine knot. This motif underpins efforts to re‐engineer cyclotides for agrochemical and therapeutic applications. We further show that the reconstructed sequences are resistant to temperatures approaching boiling, bind to phosphatidyl‐ethanolamine lipid bilayers at micromolar affinity, and inhibit the growth of insect cells at inhibitory concentrations in the micromolar range. Interestingly, the Ancy‐b cyclotide had a higher oxidative folding yield than its comparator cyclotide cyO2, which belongs to the bracelet cyclotide subfamily known to be notoriously difficult to fold. Overall, this study provides new cyclotide sequences not yet found naturally that could be valuable starting points for the understanding of cyclotide evolution and for further optimization as drug leads.
Global, regional, and national burden of blindness and vision loss attributable to high fasting plasma glucose from 1990 to 2019, and forecasts to 2030: A systematic analysis for the Global Burden of Disease Study 2019
Authors: Li Cong , Hua Guangyao , Liu Shunming , Yu Honghua , Yang Xiaohong , Liu Lei 
Published: April 2024

AbstractAimsTo systematically clarify the spatiotemporal trends, and age‐sex‐specific blindness and vision loss (BVL) burden due to high fasting plasma glucose (HFPG) from 1990 to 2019, and project this burden over the next decade.Materials and MethodsWe obtained the number and rate of years lived with disability (YLDs) for the BVL burden attributable to HFPG by age, sex, socio‐demographic index (SDI), and location between 1990 and 2019 from the Global Burden of Disease (GBD) 2019 database. The average annual percentage changes (AAPCs) were calculated to assess the temporal trends of HFPG‐attributable BVL burden. The Bayesian age‐period‐cohort model was used to predict the HFPG‐attributable BVL burden.ResultsIn 2019, the global number and age‐standardized rate (ASR) for YLDs of BVL attributable to HFPG were 673.13 (95% UI: 159.52 to 1565.34) thousand and 8.44 (95% UI: 2.00 to 19.63) per 100,000 people, respectively. The highest burdens were found in Oceania, South Asia, and Southeast Asia, and the BVL burden due to HFPG was higher in the elderly and lower SDI regions. From 1990 to 2019, the global ASR of HFPG‐attributable BVL gradually increased with AAPC (95% CI) being 0.80 (0.74 to 0.86). In addition, the HFPG‐attributable BVL burden will slightly increase in the future decade.ConclusionsThe HFPG remains the important cause of BVL worldwide, placing a substantial disease burden. From 1990 to 2019, the age‐standardized burden of BVL due to HFPG increased, and will consistently increase in the future decade, particularly in the elderly and in regions with middle SDI or below.
Unravelling the impact of climate change on honey bees: An ensemble modelling approach to predict shifts in habitat suitability in Queensland, Australia
Authors: Tennakoon Sarasie , Apan Armando , Maraseni Tek 
Published: April 2024

AbstractHoney bees play a vital role in providing essential ecosystem services and contributing to global agriculture. However, the potential effect of climate change on honey bee distribution is still not well understood. This study aims to identify the most influential bioclimatic and environmental variables, assess their impact on honey bee distribution, and predict future distribution. An ensemble modelling approach using the biomod2 package in R was employed to develop three models: a climate‐only model, an environment‐only model, and a combined climate and environment model. By utilising bioclimatic data (radiation of the wettest and driest quarters and temperature seasonality) from 1990 to 2009, combined with observed honey bee presence and pseudo absence data, this model predicted suitable locations for honey bee apiaries for two future time spans: 2020–2039 and 2060–2079. The climate‐only model exhibited a true skill statistic (TSS) value of 0.85, underscoring the pivotal role of radiation and temperature seasonality in shaping honey bee distribution. The environment‐only model, incorporating proximity to floral resources, foliage projective cover, and elevation, demonstrated strong predictive performance, with a TSS of 0.88, emphasising the significance of environmental variables in determining habitat suitability for honey bees. The combined model had a higher TSS of 0.96, indicating that the combination of climate and environmental variables enhances the model's performance. By the 2020–2039 period, approximately 88% of highly suitable habitats for honey bees are projected to transition from their current state to become moderate (14.84%) to marginally suitable (13.46%) areas. Predictions for the 2060–2079 period reveal a concerning trend: 100% of highly suitable land transitions into moderately (0.54%), marginally (17.56%), or not suitable areas (81.9%) for honey bees. These results emphasise the critical need for targeted conservation efforts and the implementation of policies aimed at safeguarding honey bees and the vital apiary industry.
From distress to anger to shame: Gender violence, empowerment, and emotional states in Ecuador
Authors: Friederic Karin 
Published: April 2024

AbstractChanging discourses and laws related to women's rights and intimate partner violence (IPV) in rural Ecuador have profoundly reshaped how local women experience and respond to violence. Women once understood violence as one strand of social suffering embedded in everyday rural life, and they resisted and managed this violence through various collective idioms of distress. Over the last two decades, however, state and non‐governmental organization (NGO) campaigns have isolated gender violence as a discrete phenomenon, emphasizing the “wrongness” of IPV, the validity of righteous anger, and the importance of a legal response to secure the separation of “liberated” women. In this article, I draw on 20 years of fieldwork to discuss how emotional responses to gender violence have shifted in tandem with changing state and transnational discourses and policies in the coastal region of Las Colinas. A deep disjuncture between neoliberal discourses of feminist empowerment and the material reality of rural women's life options leaves many women experiencing new forms of shame when they are unable to turn anger into liberation and escape gender violence in their families and communities. Focusing on the emotional states that states create reveals how political‐economic and discursive shifts are mediated through emotions and collective idioms.
Production of soft unripened cheeses using acidic and salty coagulants: Investigation of technological and sensory characteristics
Authors: Soleimani Ahmad , Nasrollahzadeh Ahmad , Khomeiri Morteza , Dehnad Danial , Arjeh Edris 
Published: April 2024

AbstractSoft cheeses are coagulated milk products obtained through acidification or applying a combination of acids and heat. In this research, in order to improve technological characteristics, the effects of different coagulants (salt and acids) and process parameters (temperature and homogenization pressure) on the organoleptic, textural, and functional characteristics of soft (unripened) cheese were investigated. The results revealed significant differences between cheeses coagulated with acid and mineral salt regarding protein recovery, fat content, and moisture content (p < .05). Acidic coagulants (74%–94%) resulted in higher cheese yield compared to mineral salt (66%–88%). Texture analysis indicated that the cheese produced with acetic acid had a firmer texture, while samples treated with citric acid exhibited better cohesiveness. Cheeses produced with minerals displayed more acceptable organoleptic characteristics regarding flavor, odor, and texture. This study offers valuable technological insights into cheese production with the highest yield and maximum acceptability.
Exploring the cholesterol‐lowering effects of cereal bran cell wall‐enriched diets
Authors: Tufail Tabussam , Saeed Farhan , Tufail Tanazzam , Bader Ul Ain Huma , Hussain Muzzamal , Noreen Sana , Shah Mohd Asif 
Published: April 2024

AbstractCell wall polysaccharides (dietary fiber) in cereal grains contribute to health benefits. The novelty of the current study was an effort to explore the in vivo therapeutic potential of different cereal bran cell walls against hypercholesterolemia. For this purpose, the cell walls were isolated from different cereal brans (wheat, maize, oats, and barley), and the intake of these cereal bran cell walls was evaluated for their anti‐lipidemic activity in normal and hypercholesterolemic rats. The serum taken from the rats was tested for cholesterol, lipid, and triglyceride profiles before and after treatment. The outcomes of the current study have shown that the cereal cell wall has a significant hypercholesterolemia effect. The biochemical parameters of the control animals were within the normal clinical ranges, indicating that the experimental diets were safe. Among cereal bran cell walls, barley bran significantly decreased cholesterol (56.35 ± 1.35 mg/dL), low‐density lipoprotein (56.35 ± 1.05 mg/dL), triglycerides (105.29 ± 1.95 mg/dL), and increased high‐density lipoprotein level (48.35 ± 1.35 mg/dL). These findings provide conclusive evidence that the cereal cell wall is beneficial in the treatment of hypercholesterolemia and may potentially provide protection against other acute, recurring, or chronic illnesses.
Experimental comparison of pool boiling characteristics between CNT, GO, and CNT + GO‐coated copper substrate
Authors: Kumar Ranjan , Kumari Prity , Rahul N. , Sen Dipak , Mandal S. K. 
Published: April 2024

AbstractThe present investigation aims to study the comparative analysis of CNT, GO, and CNT + GO nanoparticle coatings on copper surfaces under a pool boiling situation. Coating on copper surfaces is performed using the dip coating method. Pool boiling experiments are conducted for all the coated surfaces at atmospheric pressure. Water is used as a working fluid. A comparison was made based on the coated surface characteristics and pool boiling behavior of the samples. The results show that CNT + GO coating on copper surfaces is better in terms of critical heat flux (CHF) and boiling heat transfer coefficient (BHTC). It is also observed that CHF and BHTC of the CNT + GO‐coated surface are 129.19% and 194.75% higher, respectively, compared to the bare copper surface. Bubble dynamics studies were also performed for all the samples.
Tailored wrinkles for tunable sensing performance by stereolithography
Authors: Jiang Ruiyi , Pu Jie , Wang Yuxuan , Chen Jipeng , Fu Gangwen , Chen Xue , Yang Jiayu , Shen Jianghua , Sun Xing , Ding Jun , Xu Xi 
Published: April 2024

AbstractConducting polymer hydrogel can address the challenges of stricken biocompatibility and durability. Nevertheless, conventional conducting polymer hydrogels are often brittle and weak due to the intrinsic quality of the material, which exhibits viscoelasticity. This property may cause a delay in sensor response time due to hysteresis. To overcome these limitations, we have designed a wrinkle morphology three‐dimensional (3D) substrate using digital light processing technology and then followed by in situ polymerization to form interpenetrating polymer network hydrogels. This novel design results in a wrinkle morphology conducting polymer hydrogel elastomer with high precision and geometric freedom, as the size of the wrinkles can be controlled by adjusting the treating time. The wrinkle morphology on the conducting polymer hydrogel effectively reduces its viscoelasticity, leading to samples with quick response time, low hysteresis, stable cyclic performance, and remarkable resistance change. Simultaneously, the 3D gradient structure augmented the sensor's sensitivity under minimal stress while exhibiting consistent sensing performance. These properties indicate the potential of the conducting polymer hydrogel as a flexible sensor.