bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway
Authors: Wan Xinxing , Wang Linghao , Khan Md Asaduzzaman , Peng Lin , Zhang Keke , Sun Xiaoying , Yi Xuan , Wang Zhouqi , Chen Ke 
Published: March 2024

AbstractThe disruption of circadian rhythms caused by long-term shift work can cause metabolic diseases such as obesity. Early growth response 3 (EGR3) is a member of early growth response (EGR) family, which is involved in several cellular responses, had been reported as a circadian rhythm gene in suprachiasmatic nucleus. In this research, EGR3 was found to be widely expressed in the different tissue of human and mice, and downregulated in adipose tissue of obese subjects and high-fat diet mice. Moreover, EGR3 was found negatively regulated by cortisol. In addition, EGR3 is a key negative modulator of hADSCs and 3T3-L1 adipogenesis via regulating HDAC6, which is a downstream target gene of EGR3 and a negative regulator of adipogenesis and lipogenesis. These findings may explain how circadian rhythm disorder induced by shift works can cause obesity. Our study revealed a potential therapeutic target to alleviate metabolic disorders in shift workers and may provide better health guidance to shift workers.
Interplay of socioeconomic status, cognition, and school performance in the ABCD sample
Authors: Langensee Lara , Rumetshofer Theodor , Mårtensson Johan 
Published: March 2024

AbstractComing from a disadvantaged background can have negative impact on an individual’s educational trajectory. Some people however seem unaffected and cope well with the demands and challenges posed by school education, despite growing up in adverse conditions, a phenomenon termed academic resilience. While it is uncertain which underlying factors make some people more likely to circumvent unfavorable odds than others, both socioeconomic status (SES) and cognitive ability have robustly been linked to school performance. The objective of the present work is to investigate if individual cognitive abilities and SES interact in their effect on grades. For this purpose, we analyzed SES, cognitive, and school performance data from 5001 participants from the Adolescent Brain Cognitive Development (ABCD) Study. Ordinal logistic regression models suggest similar patterns of associations between three SES measures (parental education, income-to-needs ratio, and neighborhood deprivation) and grades at two timepoints, with no evidence for interaction effects between SES and time. Parental education and income-to-needs ratio were associated with grades at both timepoints, irrespective of whether cognitive abilities were modeled or not. Neighborhood deprivation, in contrast, was only a statistically significant predictor of reported grades when cognitive abilities were not factored in. Cognitive abilities interacted with parental education level, meaning that they could be a safeguard against effects of SES on school performance.
Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming
Authors: deCamp Allan C. , Corcoran Martin M. , Fulp William J. , Willis Jordan R. , Cottrell Christopher A. , Bader Daniel L. V. , Kalyuzhniy Oleksandr , Leggat David J. , Cohen Kristen W. , Hyrien Ollivier , Menis Sergey , Finak Greg , Ballweber-Fleming Lamar , Srikanth Abhinaya , Plyler Jason R. , Rahaman Farhad , Lombardo Angela , Philiponis Vincent , Whaley Rachael E. , Seese Aaron , Brand Joshua , Ruppel Alexis M. , Hoyland Wesley , Mahoney Celia R. , Cagigi Alberto , Taylor Alison , Brown David M. , Ambrozak David R. , Sincomb Troy , Mullen Tina-Marie , Maenza Janine , Kolokythas Orpheus , Khati Nadia , Bethony Jeffrey , Roederer Mario , Diemert David , Koup Richard A. , Laufer Dagna S. , McElrath Juliana M. , McDermott Adrian B. , Karlsson Hedestam Gunilla B. , Schief William R. 
Published: March 2024

AbstractVaccine priming immunogens that activate germline precursors for broadly neutralizing antibodies (bnAbs) have promise for development of precision vaccines against major human pathogens. In a clinical trial of the eOD-GT8 60mer germline-targeting immunogen, higher frequencies of vaccine-induced VRC01-class bnAb-precursor B cells were observed in the high dose compared to the low dose group. Through immunoglobulin heavy chain variable (IGHV) genotyping, statistical modeling, quantification of IGHV1-2 allele usage and B cell frequencies in the naive repertoire for each trial participant, and antibody affinity analyses, we found that the difference between dose groups in VRC01-class response frequency was best explained by IGHV1-2 genotype rather than dose and was most likely due to differences in IGHV1-2 B cell frequencies for different genotypes. The results demonstrate the need to define population-level immunoglobulin allelic variations when designing germline-targeting immunogens and evaluating them in clinical trials.
A new circa 2007 biomass map for China differs significantly from existing maps
Authors: Dong Wenquan , Mitchard Edward T. A. , Santoro Maurizio , Chen Man , Wheeler Charlotte E. 
Published: March 2024

AbstractThe forest area of China is the fifth largest of any country, and unlike in many other countries, in recent decades its area has been increasing. However, there are substantial differences in estimates of the amount of carbon this forest contains, ranging from 3.92 to 17.02 Pg C for circa 2007. This makes it unclear how the changes in China’s forest area contribute to the global carbon cycle. We generate a circa 2007 aboveground biomass (AGB) map at a resolution of 50 m using optical, radar and LiDAR satellite data. Our estimates of total carbon stored in the forest in China was 9.52 Pg C, with an average forest AGB of 104 Mg ha−1. Compared with three existing AGB maps, our AGB map showed better correlation with a distributed set of forest inventory plots. In addition, our high resolution AGB map provided more details on spatial distribution of forest AGB, and is likely to help understand the carbon storage changes in China’s forest.
Low energy consumption layout of exhibition buildings in Yangtze River Delta region
Authors: Zhu Wei , Han Xinyu , Ying Xiaoyu , Tan Yang , Shen Liying , Huangfu Fanyu 
Published: March 2024

AbstractThe issue of high energy consumption in exhibition buildings has long been a focal point in the field of architectural design. However, current energy consumption assessments for exhibition buildings mainly focus on post-construction evaluations, lacking corresponding guidance during the initial design phase. To address this issue, this study selected 48 well-known exhibition buildings both domestically and internationally as research subjects. Utilizing scatter plot curve fitting, it was discovered that there exists a nonlinear quadratic relationship between the building area of the first floor and the courtyard area. Based on this relationship, four typical layouts were established to match the climatic characteristics of Hangzhou, a representative region in the Yangtze River Delta of China. Taking into account regional architectural features, the study specifically examined the impact of different orientations and window-to-wall ratios on energy consumption levels. The influence of these factors on energy consumption was analyzed using the DesignBuilder software. The results revealed that there exists an optimal window-to-wall ratio for exhibition buildings, with parallel, L-shaped enclosed south-facing courtyards, and U-shaped enclosed east-facing courtyards showing greater energy efficiency. This research provides guidance for designing exhibition buildings that are energy-efficient and foster a harmonious indoor–outdoor relationship.
Histology-validated electromagnetic characterization of ex-vivo ovine lung tissue for microwave-based medical applications
Authors: Vidjak Klementina , Farina Laura , Challapalli Ritihaas Surya , Quinn Anne Marie , O’Halloran Martin , Lowery Aoife , Ruvio Giuseppe , Cavagnaro Marta 
Published: March 2024

AbstractMicrowave thermal ablation is an established therapeutic technique for treating malignant tissue in various organs. Its success greatly depends on the knowledge of dielectric properties of the targeted tissue and on how they change during the treatment. Innovation in lung navigation has recently increased the clinical interest in the transbronchial microwave ablation treatment of lung cancer. However, lung tissue is not largely characterized, thus its dielectric properties investigation prior and post ablation is key. In this work, dielectric properties of ex-vivo ovine lung parenchyma untreated and ablated at 2.45 GHz were recorded in the 0.5–8 GHz frequency range. The measured dielectric properties were fitted to 2-pole Cole–Cole relaxation model and the obtained model parameters were compared. Based on observed changes in the model parameters, the physical changes of the tissue post-ablation were discussed and validated through histology analysis. Additionally, to investigate the link of achieved results with the rate of heating, another two sets of samples, originating from both ovine and porcine tissues, were heated with a microwave oven for different times and at different powers. Dielectric properties were measured in the same frequency range. It was found that lung tissue experiences a different behavior according to heating rates: its dielectric properties increase post-ablation while a decrease is found for low rates of heating. It is hypothesized, and validated by histology, that during ablation, although the tissue is losing water, the air cavities deform, lowering air content and increasing the resulting tissue properties.
Point-of-care lung ultrasound predicts hyperferritinemia and hospitalization, but not elevated troponin in SARS-CoV-2 viral pneumonitis in children
Authors: Walsh Paul , Hankins Andrea , Bang Heejung 
Published: March 2024

AbstractSARS-CoV-2 often causes viral pneumonitis, hyperferritinemia, elevations in D-dimer, lactate dehydrogenase (LDH), transaminases, troponin, CRP, and other inflammatory markers. Lung ultrasound is increasingly used to diagnose and stratify viral pneumonitis severity. We retrospectively reviewed 427 visits in patients aged 14 days to 21 years who had had a point-of-care lung ultrasound in our pediatric emergency department from 30/November/2019 to 14/August/2021. Lung ultrasounds were categorized using a 6-point ordinal scale. Lung ultrasound abnormalities predicted increased hospitalization with a threshold effect. Increasingly abnormal laboratory values were associated with decreased discharge from the ED and increased admission to the ward and ICU. Among patients SARS-CoV-2 positive patients ferritin, LDH, and transaminases, but not CRP or troponin were significantly associated with abnormalities on lung ultrasound and also with threshold effects. This effect was not demonstrated in SARS-CoV-2 negative patients. D-Dimer, CRP, and troponin were sometimes elevated even when the lung ultrasound was normal.
The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
Authors: Banik Jewel , Moreira Ana Rita Silva , Lim Juchan , Tomlinson Sophia , Hardy Linda L. , Lagasse Alex , Haney Anessa , Crimmins Meghan R. , Boehm Ulrich , Odle Angela K. , MacNicol Melanie C. , Childs Gwen V. , MacNicol Angus M. 
Published: March 2024

AbstractThe pituitary functions as a master endocrine gland that secretes hormones critical for regulation of a wide variety of physiological processes including reproduction, growth, metabolism and stress responses. The distinct hormone-producing cell lineages within the pituitary display remarkable levels of cell plasticity that allow remodeling of the relative proportions of each hormone-producing cell population to meet organismal demands. The molecular mechanisms governing pituitary cell plasticity have not been fully elucidated. Our recent studies have implicated a role for the Musashi family of sequence-specific mRNA binding proteins in the control of pituitary hormone production, pituitary responses to hypothalamic stimulation and modulation of pituitary transcription factor expression in response to leptin signaling. To date, these actions of Musashi in the pituitary appear to be mediated through translational repression of the target mRNAs. Here, we report Musashi1 directs the translational activation, rather than repression, of the Prop1, Gata2 and Nr5a1 mRNAs which encode key pituitary lineage specification factors. We observe that Musashi1 further directs the translational activation of the mRNA encoding the glycolipid Neuronatin (Nnat) as determined both in mRNA reporter assays as well as in vivo. Our findings suggest a complex bifunctional role for Musashi1 in the control of pituitary cell function.
Cleaning performance of electric toothbrushes around brackets applying different brushing forces: an in-vitro study
Authors: Rominger Reto L. , Patcas Raphael , Hamza Blend , Schätzle Marc , Wegehaupt Florian J. , Hersberger-Zurfluh Monika A. 
Published: March 2024

AbstractThroughout treatment with fixed orthodontic appliances, effective plaque control is crucial to maintaining dental health. This in-vitro study evaluated the cleaning performance of eleven different brush heads of seven electric toothbrushes (oscillating-rotating and sonic motions) and varying brushing forces around orthodontic brackets. Six Mini Diamond® Twin brackets were placed on black-stained front teeth. Teeth were coated with white titanium oxide and brushed in a machine six times for one minute with two different brushing forces (1 N and 1.5 N). Eleven different brush heads were evaluated (either oscillating-rotating or sonic movements). The teeth were scanned and planimetrically evaluated after brushing. Three detailed plaque areas (DPAs) were created: proximal (< 1 mm to bracket), mid-tier (1–2 mm to bracket), and distant (> 2 mm to bracket). The proportion of contaminated proximal, mid-tier, and distant surfaces (white regions) in relation to the respective DPA was calculated. Independent of brushing forces, places with a higher distance (> 2 mm) to the orthodontic bracket had the least amount of residual contamination, followed by areas with a minor (1–2 mm) and proximal distance (< 1 mm). In all of the brushes tested and for both estimated brushing forces, the region with the highest residual contamination was the proximal area. The brush heads of the Paro® Sonic toothbrush left the least amount of residual contamination. The cleaning performance of electric toothbrushes around brackets on upper incisors varied across the brushes examined. The proximal area has the most residual contamination. Furthermore, 9 out of 11 toothbrushes cleaned more successfully with 1.5 N than with 1 N brushing force.
Climate change, thermal anomalies, and the recent progression of dengue in Brazil
Authors: Barcellos Christovam , Matos Vanderlei , Lana Raquel Martins , Lowe Rachel 
Published: March 2024

AbstractDengue is rapidly expanding its transmission area across Brazil and much of South America. In this study, data-mining techniques were used to identify climatic and demographic indicators that could explain the recent (2014–2020) and simultaneous trends of expansion and exacerbation of the incidence in some regions of Brazil. The previous circulation of the virus (dengue incidence rates between 2007 and 2013), urbanization, and the occurrence of temperature anomalies for a prolonged period were the main factors that led to increased incidence of dengue in the central region of Brazil. Regions with high altitudes, which previously acted as a barrier for dengue transmission, became areas of high incidence rates. The algorithm that was developed during this study can be utilized to assess future climate scenarios and plan preventive actions.
Development of a rock-bit interaction analytical model by considering the in-situ stresses for a bottom-hole element
Authors: Zafarian Habiballah , Ameri Mohammad Javad , Dolatyari Alireza 
Published: March 2024

AbstractPDC drill bits are an important part of drilling engineering, but improper selection or design can lead to decreased performance and increased costs. Then, accurate modeling of rock-bit interaction for Oil/gas well drilling is critical. Although several mathematical models are presented for this purpose, they have not been able to present a comprehensive model for the rock-bit interaction. In-situ stresses in real drilling conditions affect the force required for rock failure. However, the models proposed so far either have not considered the effects of in-situ stresses or have assumed that the rock failure angle in the downhole conditions is equal to the one calculated in the atmospheric conditions. In this work, after reviewing the background of studies conducted on the rock and bit interaction, with an analytical method, stresses applied to the bottom hole element are examined, including stresses resulting from bit and in-situ stresses. Based on the principle of superposition, the total stress imposed on the bottom hole element is calculated to determine the angle and force of rock cutting. Finally, a novel mathematical model of rock-bit interaction in vertical and deviated oil/gas wells drilling by Considering In-Situ Stresses is presented. Also, the study compares the current model to the Nishimatsu and Xin Ling models using data from a southwest field in Iran. The results show that the simplifying assumption made by previous models leads to a significant underestimation of the failure angle and the amount of force required to the rock failure, with reductions of up to 21% and 48%, respectively, in the case of a vertical well. In an inclined well, the current model predicts cutting force at about 0.14 of that predicted by the previous model.
Muscle strength and foot pressure vary depending on the type of foot pain
Authors: Lee Jin Hyuck , Hwang Jangsun , Park Hyungyu , Kang Hyunoh , Song Wonkyu , Choi Doo-Ah , Seong Cheul-Hun , Jang Woo Young 
Published: March 2024

AbstractThis study compared muscle strength and foot pressure among patients with metatarsalgia, patients with plantar fasciitis, and healthy controls. A total of 31 patients with foot pain (14 metatarsalgia and 17 plantar fasciitis) and 29 healthy controls participated in the study. The strengths of the plantar flexor and hip muscles were measured using isokinetic and handheld dynamometers, respectively. Foot pressure parameters, including the pressure–time integral (PTI) and foot arch index (AI), were assessed using pedobarography. Compared with the healthy control group, plantar flexor strength was significantly reduced in the affected feet of the metatarsalgia and plantar fasciitis groups (F = 0.083, all p < 0.001); however, hip strength was significantly decreased only in the affected feet of the metatarsalgia group (F = 20.900, p < 0.001). Plantar flexor (p < 0.001) and hip (p = 0.004) strength were significantly lower in the metatarsalgia group than in the plantar fasciitis group. The PTI was lower in the forefeet of the affected feet in the metatarsalgia (p < 0.001) and plantar fasciitis (p = 0.004) groups. Foot AI (p < 0.001) was significantly reduced only in the metatarsalgia group. These results suggest the need to consider the evaluation of muscle strength and foot pressure in both feet for the diagnosis and treatment of foot pain.
Uniformly dispersed ruthenium nanoparticles on porous carbon from coffee waste outperform platinum for hydrogen evolution reaction in alkaline media
Authors: Sukhbaatar Bayaraa , Qing Wang , Seo Jinmyeong , Yoon Sanghwa , Yoo Bongyoung 
Published: March 2024

AbstractBiowaste-derived carbon materials are a sustainable, environmentally friendly, and cost-effective way to create valuable materials. Activated carbon can be a supporting material for electrocatalysts because of its large specific surface area and porosity. However, activated carbon has low catalytic activity and needs to be functionalized with heteroatoms, metals, and combinations to improve conductivity and catalytic activity. Ruthenium (Ru) catalysts have great potential to replace bench market catalysts in hydrogen evolution reaction (HER) applications due to their similar hydrogen bond strength and relatively lower price. This study reports on the synthesis and characterizations of carbon-supported Ru catalysts with large surface areas (~ 1171 m2 g−1) derived from coffee waste. The uniformly dispersed Ru nanoparticles on the porous carbon has excellent electrocatalytic activity and outperformed the commercial catalyst platinum on carbon (Pt/C) toward the HER. As-synthesized catalyst needed only 27 mV to reach a current density of 10 mA cm−2, 58.4 mV dec−1 Tafel slope, and excellent long-term stability. Considering these results, the Ru nanoparticles on coffee waste-derived porous carbon can be utilized as excellent material that can replace platinum-based catalysts for the HER and contribute to the development of eco-friendly and low-cost electrocatalyst materials.
Workplace digitalization and workload: changes and reciprocal relations across 3 years
Authors: Zacher Hannes , Rudolph Cort W. 
Published: March 2024

AbstractThis article reports the results of a 33-wave longitudinal study of changes in, and reciprocal relations between, workplace digitalization and workload. Monthly data were collected between April 2020 and December 2022 from n = 1661 employees in Germany. Based on theoretical models of workplace information and communication technology use, stress, and coping, we hypothesized both positive and negative within-person effects of digitalization on workload, and vice versa. Results of an autoregressive latent trajectory model with structured residuals (ALT-SR) showed on-average positive linear trajectories in digitalization, but not in workload over time. Moreover, higher digitalization was associated with subsequently higher levels of workload, and vice versa. This pattern of results suggests a dynamic, reciprocal process wherein positive deviations from one’s average trajectory of digitalization (workload) are associated with subsequently higher levels of workload (digitalization). We additionally find evidence for linear trends in these within-person processes, suggesting that the strength of the within-person effects of digitalization on workload, and of workload on digitalization, becomes more strongly positive over time. Practitioners developing work design interventions could focus on ways to reduce the detrimental impact of digitalization on increased workload, while simultaneously encouraging the potential of digitalization to help employees cope effectively with their workload.
Model of zonular forces on the lens capsule during accommodation
Authors: Schachar Ronald A. , Schachar Ira H. , Kumar Shubham , Feldman Eitan I. , Pierscionek Barbara K. , Cosman Pamela C. 
Published: March 2024

AbstractHow the human eye focuses for near; i.e. accommodates, is still being evaluated after more than 165 years. The mechanism of accommodation is essential for understanding the etiology and potential treatments for myopia, glaucoma and presbyopia. Presbyopia affects 100% of the population in the fifth decade of life. The lens is encased in a semi-elastic capsule with attached ligaments called zonules that mediate ciliary muscle forces to alter lens shape. The zonules are attached at the lens capsule equator. The fundamental issue is whether during accommodation all the zonules relax causing the central and peripheral lens surfaces to steepen, or the equatorial zonules are under increased tension while the anterior and posterior zonules relax causing the lens surface to peripherally flatten and centrally steepen while maintaining lens stability. Here we show with a balloon capsule zonular force model that increased equatorial zonular tension with relaxation of the anterior and posterior zonules replicates the topographical changes observed during in vivo rhesus and human accommodation of the lens capsule without lens stroma. The zonular forces required to simulate lens capsule configuration during in vivo accommodation are inconsistent with the general belief that all the zonules relax during accommodation.