bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observation of fixed lines induced by a nonlinear resonance in the CERN Super Proton Synchrotron
Authors: Bartosik H. , Franchetti G. , Schmidt F. 
Published: March 2024

AbstractThe motion of systems with linear restoring forces and recurring nonlinear perturbations is of central importance in physics. When a system’s natural oscillation frequencies and the frequency of the nonlinear restoring forces satisfy certain algebraic relations, the dynamics become resonant. In accelerator physics, an understanding of resonances and nonlinear dynamics is crucial for avoiding the loss of beam particles. Here we confirm the theoretical prediction of the dynamics for a single two-dimensional coupled resonance by observing so-called fixed lines. Specifically, we use the CERN Super Proton Synchrotron to measure the position of a particle beam at discrete locations around the accelerator. These measurements allow us to construct the Poincaré surface of section, which captures the main features of the dynamics in a periodic system. In our setting, any resonant particle passing through the Poincaré surface of section lies on a curve embedded in a four-dimensional phase space, the fixed line. These findings are relevant for mitigating beam degradation and thus for achieving high-intensity and high-brightness beams, as required for both current and future accelerator projects.
Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site
Authors: Shioi Takuro , Hatazawa Suguru , Oya Eriko , Hosoya Noriko , Kobayashi Wataru , Ogasawara Mitsuo , Kobayashi Takehiko , Takizawa Yoshimasa , Kurumizaka Hitoshi 
Published: March 2024

AbstractRAD51 is the central eukaryotic recombinase required for meiotic recombination and mitotic repair of double-strand DNA breaks (DSBs)1,2. However, the mechanism by which RAD51 functions at DSB sites in chromatin has remained elusive. Here we report the cryo-electron microscopy structures of human RAD51–nucleosome complexes, in which RAD51 forms ring and filament conformations. In the ring forms, the N-terminal lobe domains (NLDs) of RAD51 protomers are aligned on the outside of the RAD51 ring, and directly bind to the nucleosomal DNA. The nucleosomal linker DNA that contains the DSB site is recognized by the L1 and L2 loops—active centres that face the central hole of the RAD51 ring. In the filament form, the nucleosomal DNA is peeled by the RAD51 filament extension, and the NLDs of RAD51 protomers proximal to the nucleosome bind to the remaining nucleosomal DNA and histones. Mutations that affect nucleosome-binding residues of the RAD51 NLD decrease nucleosome binding, but barely affect DNA binding in vitro. Consistently, yeast Rad51 mutants with the corresponding mutations are substantially defective in DNA repair in vivo. These results reveal an unexpected function of the RAD51 NLD, and explain the mechanism by which RAD51 associates with nucleosomes, recognizes DSBs and forms the active filament in chromatin.
Co-dependent excitatory and inhibitory plasticity accounts for quick, stable and long-lasting memories in biological networks
Authors: Agnes Everton J. , Vogels Tim P. 
Published: March 2024

AbstractThe brain’s functionality is developed and maintained through synaptic plasticity. As synapses undergo plasticity, they also affect each other. The nature of such ‘co-dependency’ is difficult to disentangle experimentally, because multiple synapses must be monitored simultaneously. To help understand the experimentally observed phenomena, we introduce a framework that formalizes synaptic co-dependency between different connection types. The resulting model explains how inhibition can gate excitatory plasticity while neighboring excitatory–excitatory interactions determine the strength of long-term potentiation. Furthermore, we show how the interplay between excitatory and inhibitory synapses can account for the quick rise and long-term stability of a variety of synaptic weight profiles, such as orientation tuning and dendritic clustering of co-active synapses. In recurrent neuronal networks, co-dependent plasticity produces rich and stable motor cortex-like dynamics with high input sensitivity. Our results suggest an essential role for the neighborly synaptic interaction during learning, connecting micro-level physiology with network-wide phenomena.
Abnormal hemoglobin anti-Lepore Hong Kong compound with β0-thalassemia ameliorate thalassemia severity when co-inherited with α-thalassemia
Authors: Bao Xiuqin , Wang Jicheng , Qin Danqing , Yao Cuize , Liang Jie , Liang Kailing , Du Li 
Published: March 2024

AbstractAbnormal hemoglobin anti-Lepore Hong Kong is a rare βδ fusion variants resulting from non-homologous crossover during meiosis. Anti-Lepore Hong Kong is known to consistently exhibit significantly increased level of HbA2. In this study, we used multiplex ligation-dependent probe amplification (MLPA) and single molecular real-time (SMRT) sequencing, as well as Sanger sequencing, to identify variants in five unrelated families with abnormal elevated HbA2 level. All probands in these five families were found to be heterozygous for anti-Lepore Hong Kong. Among them, two families showed co-occurrence of β0-thalassemia and α-thalassemia (–SEA/ or αCSα/). Heterozygotes for anti-Lepore Hong Kong displayed an average HbA2 level of 17.7% and behaved normal. However, when combined with β0-thalassemia and α-thalassemia, the probands exhibited higher HbA2 level (30.2–40.8%) and behaved with β-thalassemia trait. Furthermore, determination of the α/β-mRNA ratio revealed a slight downregulation of β-globin, similar to that of β-thalassemia minor. Our study is the first to identify compound heterozygotes for anti-Lepore Hong Kong, β0-thalassemia and α-thalassemia, provide valuable information for prenatal counseling.
A lower connection to nature is related to lower mental health benefits from nature contact
Authors: Chang Chia-chen , Lin Brenda B. , Feng Xiaoqi , Andersson Erik , Gardner John , Astell-Burt Thomas 
Published: March 2024

AbstractIncreasing evidence demonstrates the psychological benefits of nature contact. However, the evidence is often established at the population level, and the individual differences in the psychological benefits gained from nature are considered negligible variations. In this study, we performed a cross-sectional online survey in Brisbane and Sydney, Australia, from April 15th and May 15th, 2021 around one year after the first covid-19 pandemic lockdowns. The results show that individuals with a stronger connection to nature are linked with a lower level of stress and anxiety with increased frequency in public greenspace visits, while such an association is less clear for individuals with a weaker connection to nature. We also find that, through the answer to an open-ended question, individuals with a lower connection to nature tend to mention nature-related words less as the reason for visiting greenspace. This indicates that a person’s connection to nature is linked with how they interact with nature and thus might determine whether and how much psychological benefit a person gains from experiencing nature.
Momentum informed muon scattering tomography for monitoring spent nuclear fuels in dry storage cask
Authors: Bae JungHyun , Montgomery Rose , Chatzidakis Stylianos 
Published: March 2024

AbstractDevelopment of an effective monitoring method for spent nuclear fuel (SNF) in a dry storage cask (DSC) is important to meet the increasing demand for dry storage investigations. The DSC investigation should provide information about the quantity of stored SNF, and quality assurance of materials should be possible without opening the cask. However, traditional nondestructive examination (NDE) methods such as x-rays are difficult to deploy for DSC investigation because a typical DSC is intentionally designed to shield against radiation. To address this challenge, cosmic ray muons (CRMs) are used as an alternative NDE radiation probe because they can easily penetrate an entire DSC system; however, a wide application of muons is often hindered due to the naturally low CRM flux (~104 muons/m2/min). This paper introduces a newly proposed imaging algorithm, momentum-informed muon scattering tomography (MMST), and presents how a limitation of the current muon scattering tomography technique has been addressed by measuring muon momentum. To demonstrate its functionality, a commercial DSC with 24 pressurized light water reactor fuel assemblies (FAs) and the MMST system were designed in GEANT4. Three noticeable improvements were observed for MMST system as a DSC investigation tool: (1) a signal stabilization, (2) an enhanced capability to differentiate various materials, and (3) statistically increased precision to identify and locate missing FAs. The results show that MMST improves the investigation accuracy from 79 to 98% when one FA is missing and 51% to 88% when one-half FA is missing. The advancement of the NDE technique using CRM for DSC verification is expected to resolve long-standing problems in increasing demand for DSC inspections and nuclear security.
Geospatial methodology for determining the regional prevalence of hospital-reported childhood intussusception in patients from India
Authors: Dixit Shikha , Das Manoja Kumar , Ramadugu Durga Chitra , Arora Narendra Kumar ,   The INCLEN Intussusception Surveillance Network Study Group, Ray Arindam , Wakhlu Ashish , Vyas Bhadresh R. , Bhat Javeed Iqbal , Goswami Jayanta K. , Mathai John , Kameswari K. , Bharadia Lalit , Sankhe Lalit , Ajaya Kumar M. K. , Mohan Neelam , Jena Pradeep K. , Sarangi Rachita , Shad Rashmi , Debbarma Sanjib K. , Shyamala J. , Ratan Simmi K. , Sarkar Suman , Kumar Vijayendra , Dubey Anand P. , Gupta Atul , Tripathy Bikasha Bihary , Sam Cenita J. , Mufti Gowhar Nazir , Trivedi Harsh , Shad Jimmy , Lahiri Kaushik , Luthra Meera , Padmalatha P. , Kumar Rakesh , Sarkar Ruchirendu , Kumar A. Santosh , Sahoo Subrat Kumar , Ghosh Sunil K. , Mane Sushant , Charoo Bashir Ahmad , Prasad G. Rajendra , Kumar S. Harish , Jothilakshmi K. , Sarkar Nihar Ranjan , Arunachalam Pavai , Mohapatra Satya S. G. , Garge Saurabh 
Published: March 2024

AbstractBoth developed and developing countries carry a large burden of pediatric intussusception. Sentinel site surveillance-based studies have highlighted the difference in the regional incidence of intussusception. The objectives of this manuscript were to geospatially map the locations of hospital-confirmed childhood intussusception cases reported from sentinel hospitals, identify clustering and dispersion, and reveal the potential causes of the underlying pattern. Geospatial analysis revealed positive clustering patterns, i.e., a Moran’s I of 0.071 at a statistically significant (p value < 0.0010) Z score of 16.14 for the intussusception cases across India (cases mapped n = 2221), with 14 hotspots in two states (Kerala = 6 and Tamil Nadu = 8) at the 95% CI. Granular analysis indicated that 67% of the reported cases resided < 50 km from the sentinel hospitals, and the average travel distance to the sentinel hospital from the patient residence was calculated as 47 km (CI 95% min 1 km–max 378 km). Easy access and facility referral preferences were identified as the main causes of the existing clustering pattern of the disease. We recommend designing community-based surveillance studies to improve the understanding of the prevalence and regional epidemiological burden of the disease.
The contribution of vitamin D insufficiency to the onset of steatotic liver disease among individuals with metabolic dysfunction
Authors: Lee Su-bin , Jin Mi Hyeon , Yoon Jeong-Hyun 
Published: March 2024

AbstractThe interplay between fatty liver disease (FLD) and metabolic dysfunction has given rise to the concept of metabolic associated fatty liver disease (MAFLD). With vitamin D insufficiency frequently co-occurring with FLD and linked to metabolic abnormalities, this study investigates the potential role of vitamin D in the development of MAFLD. In this cross-sectional analysis, 22,476 participants with baseline metabolic dysfunction and known serum 25-OH-vitamin D3 levels were examined. The fatty liver index (FLI) was utilized to predict FLD, dividing subjects into MAFLD and non-MAFLD groups. Further stratification by vitamin D levels (sufficient vs. insufficient) and gender provided a detailed assessment through binary logistic regression to determine the association of vitamin D status with MAFLD incidence. Vitamin D insufficiency correlated with a higher MAFLD incidence in metabolically impaired individuals. Post-adjustment, the correlation was stronger (men: aOR = 1.32, 95% CI = 1.22–1.43, P < 0.001; women: aOR = 1.53, 95% CI = 1.18–1.98, P = 0.001). Lower serum 25-OH-vitamin D3 levels were found in MAFLD patients across genders (men: P = 0.003; women: P = 0.014), with a higher prevalence of insufficiency in MAFLD cases (men: P = 0.007; women: P = 0.003). The vitamin D-MAFLD link was stable across subgroups and using varying FLI criteria. Our findings indicate a clear association between vitamin D insufficiency and increased MAFLD incidence, underscoring the potential of vitamin D as an anti-lipogenic and anti-fibrotic agent.
The influence of cultivation conditions on the formation of psychoactive salvinorin A, salvinorin B, rosmarinic acid and caffeic acid in Coleus scutellarioides
Authors: Jakobina Maciej , Łyczko Jacek , Szumny Antoni , Galek Renata 
Published: March 2024

AbstractColeus scutellarioides (L.) Benth. is a popular species in the world, known for its characteristic magnificent colourful leaves. The study has revealed that the contents of rosmarinic acid and caffeic acid are significantly higher in the plant tissues cultivated in vivo than when under in vitro conditions. The performed qualitative and quantitative analyses confirmed the presence (whose averaged content) of salvinorin A (6.65 µg/1 g of fresh plant) and salvinorin B (50.46 µg/1 g of fresh plant) in tissues of Coleus scutellarioides (L.) Benth. of ‘Electric lime’ variety. The greatest quantities of these compounds were recorded for plants cultivated in vitro on the MS medium enriched with NAA (naphthyl-1-acetic acid) at a concentration of 0.5 mg∙ dm–3. The research detected differences in the amounts of compounds between plants grown in vivo and those cultivated in vitro. Addition of plant growth regulators into the breeding medium under in vitro conditions was found affecting the amounts of compounds in plant tissues.
Satellite License Plate: passive and compact optical spectrally-based identification method for satellites
Authors: Bakker David L. , Castro do Amaral Gustavo , Di Iorio Eugenio , Feenstra Linda W. , Ferrario Ivan , Perlingeiro Breno , Silvestri Fabrizio 
Published: March 2024

AbstractSatellite identification and tracking is fundamental for decision making in space traffic management. Cooperative optical identification methods enlarge the toolbox of identification techniques which currently count on radar and passive optical observations. Here we present a cooperative method to identify satellites from the ground by means of laser techniques: the Satellite License Plate (SLP). SLP employs unique spectrally-encoded retroreflecting tags mounted on the satellite. The interrogation of the tags could be performed with laser enabled optical ground stations. The benefit of the concept is that the tag concept is fully passive, minimally invasive, and scalable from tens to hundreds of unique combinations, allowing to map a large number of satellites on a single orbit. The SLP method is here described by means of end-to-end theoretical analyses on the final performance of identification and experimental results gathered during km-range ground-to-ground free space tests.
A population genomics analysis of the Aotearoa New Zealand endemic rewarewa tree (Knightia excelsa)
Authors: McCartney Ann M. , Koot Emily , Prebble Jessica M. , Jibran Rubina , Mitchell Caroline , Podolyan Ana , Fergus Alexander J. , Arnst Elise , Herron Katie E. , Houliston Gary , Buckley Thomas R. , Chagné David 
Published: March 2024

AbstractRewarewa (Knightia excelsa, Proteaceae) is a tree species endemic to Aotearoa New Zealand, with a natural distribution spanning Te Ika-a-Māui (North Island) and the top of Te Waipounamu (South Island). We used the pseudo-chromosome genome assembly of rewarewa as a reference and whole genome pooled sequencing from 35 populations sampled across Aotearoa New Zealand, including trees growing on Māori-owned land, to identify 1,443,255 single nucleotide polymorphisms (SNPs). Four genetic clusters located in the northern North Island (NNI), eastern North Island (NIE), western and southern North Island (NIWS), and the South Island (SI) were identified. Gene flow was revealed between the SI and NIE genetic clusters, plus bottleneck and contraction events within the genetic clusters since the mid-late Pleistocene, with divergence between North and South Island clusters estimated to have occurred ~115,000–230,000 years ago. Genotype environment analysis (GEA) was used to identify loci and genes linked with altitude, soil pH, soil carbon, slope, soil size, annual mean temperature, mean diurnal range, isothermality, annual precipitation, and precipitation seasonality. The location of the SNPs associated with these environmental variables was compared with the position of 52,192 gene-coding sequences that were predicted in the rewarewa genome using RNA sequencing. This new understanding of the genetic variation present in rewarewa and insights into the genetic control of adaptive traits will inform efforts to incorporate the species in restoration plantings and for marketing rewarewa honey based on provenance.
GP‐FMLNet: A feature matrix learning network enhanced by glyph and phonetic information for Chinese sentiment analysis
Authors: Li Jing , Zhang Dezheng , Xie Yonghong , Wulamu Aziguli , Zhang Yao 
Published: March 2024

AbstractSentiment analysis is a fine‐grained analysis task that aims to identify the sentiment polarity of a specified sentence. Existing methods in Chinese sentiment analysis tasks only consider sentiment features from a single pole and scale and thus cannot fully exploit and utilise sentiment feature information, making their performance less than ideal. To resolve the problem, the authors propose a new method, GP‐FMLNet, that integrates both glyph and phonetic information and design a novel feature matrix learning process for phonetic features with which to model words that have the same pinyin information but different glyph information. Our method solves the problem of misspelling words influencing sentiment polarity prediction results. Specifically, the authors iteratively mine character, glyph, and pinyin features from the input comments sentences. Then, the authors use soft attention and matrix compound modules to model the phonetic features, which empowers their model to keep on zeroing in on the dynamic‐setting words in various positions and to dispense with the impacts of the deceptive‐setting ones. Experiments on six public datasets prove that the proposed model fully utilises the glyph and phonetic information and improves on the performance of existing Chinese sentiment analysis algorithms.
Analysing responsible innovation along a value chain—A single‐cell protein case study
Authors: Flight Monica Hoyos , Tait Joyce , Chronopoulos Theo , Betancor Monica , Wischhusen Pauline , Burton Emily , O'Neill Helen Masey , van der Heul Kim , Hays John , Rowe Peter 
Published: March 2024

AbstractThe British Standards Institution's Publicly Available Specification 440 (PAS 440) provides a Responsible Innovation Framework (RIF) that companies can use to continuously monitor the societal, environmental and health benefits and risks of their innovations, as well as relevant changes to the supply chain and regulations. PAS 440 is intended to help companies achieve the benefits of innovation in a timely manner and avoid any potential harm or unintended misuse of a new product, process or service. Here, the authors have applied the PAS 440 RIF to a novel single‐cell protein (SCP) animal feed ingredient taking into consideration the perspectives of the value chain partners (VCPs), companies and laboratories involved in an Innovate UK research project. The authors’ findings show how VCPs can use PAS440 to demonstrate that they are innovating responsibly. Using this approach to responsible innovation along the value chain—from manufacturing scale‐up, through regulatory approval, to incorporation in animal feed and from there to food on supermarket shelves—can support the development of innovations that contribute to the economic and environmental sustainability of the animal feed sector. The authors conclude that the PAS 440 Guide can facilitate the progress of a new product throughout a value chain and contribute to coordinating responsible behaviour among companies involved in the value chain.
Parallel multi‐rate simulation scheme for modular multilevel converter‐based high‐voltage direct current with accurate simulation of high‐frequency characteristics and field programmable gate array‐based implementation
Authors: Liu Chongru , Hou Yanqi , Dong Haoyun , Lv Yipeng , Wang Xinyan , Su Chenbo 
Published: March 2024

AbstractThe real‐time simulation of the modular multilevel converter‐based high‐voltage direct current (MMC‐HVDC) transmission system has become a popular research topic. However, in order to meet the real‐time performance, the real‐time simulation technology will cause additional simulation errors for MMC‐HVDC, especially on its frequency characteristics. Therefore, a parallel multi‐rate simulation scheme for MMC‐HVDC is developed in this work to ensure accurate simulation of high‐frequency characteristics. Firstly, a non‐error method based on converter transformer decoupling is proposed to decouple the converter and alternating current system; direct current transmission line decoupling and arm decoupling methods are used to achieve decoupling among and within converters. A multi‐rate data synchronous mechanism is established by considering the differences among high‐frequency characteristics caused by delayed data interaction. Secondly, the computing architectures of the primary system solver and modular multilevel converter controller are designed based on a field programmable gate array (FPGA). The real‐time simulation platform for a four‐terminal true bipolar MMC‐HVDC is constructed based on the FPGA array. Thirdly, the factors in multi‐rate simulation affecting the simulation accuracy of high‐frequency characteristics are analysed. The simulator is shown to be accurate in steady and dynamic states. The authors also verify its applicability for further research on high‐frequency resonance based on control experiments.