bluuebunny/crossref_metadata_2025_split huggingface dataset:
TANTANGAN DALAM PEMBAHARUAN SISTEM PERADILAN MELALUI PERKEMBANGAN TEKNOLOGI: E-COURT DAN E-LITIGASI SEBAGAI SARANA MENUJU PERADILAN MODEREN DI INDONESIA
Authors: Maskanah Ummi 
Published: March 2024

Futuristically people are reluctant to settle their cases through the Courts. Not It is not uncommon for sharp criticism to be raised that the judiciary is considered slow and long, very expensive and unresponsive to justice, formalistic and technical (rechnically), and less uptodate, so that it is less efficient and effective, making it difficult for the public to obtain justice through the courts. Obtaining justice through the courts. Technological developments are utilized by the Supreme Court as a solution and at the same time to implement the principle of simple, fast, and light cost. This research is descriptive analytical, normative juridical and empirical juridical approach, analyzed qualitatively. Qualitatively analyzed. The results of the study found that the Supreme Court of the Republic of Indonesia creates a court that fulfills the principles of simple, fast and light cost through a new innovation called Electronic through a new innovation called Electronic Court (E-Court) and E-Litigation, through Supreme Court Regulation No. 3/2018 Jo. Number 3 of 2018 Jo. Perma No. 1 of 2018 and through a Cooperation Agreement between the Supreme Court of the Republic of Indonesia, the Attorney General's Office of the Republic of Indonesia, and the Ministry of Law and Human Rights of the Republic of Indonesia. Human Rights of the Republic of Indonesia Number 402/DJU/HM.01.1/4/2020, Number KEP-17/E/Ejp/04/2020, Number PAS 08.HH.05.05.05.05. PAS-08.HH.05.05 of 2020, but in practice there are still many obstacles that need to be addressed. Facilities and infrastructure and immediately revise the procedural law, both the Law on Civil Procedure procedural laws both the Civil Procedure Law and the Criminal Procedure Law.Â Keywords : Judicial System Reform; Modern Court; Electronic Court.
Determination Digital Economy of Strengthen Local Halal Tourism
Authors: Al Kautsar Syahvergio Anugrah , Maadi Alan Su’ud , Rohman Taufiqur 
Published: March 2024

The digitalization transformation of halal tourism in Indonesia is categorized as low. This study aims to reveal the influence of variables, security, fintech, brand image and infrastructure on people's decisions to travel halal in Madura. This type of research was sourced from primary data obtained from the distribution of questionnaires in the coastal area of Madura, the meeting of 100 respondents based on the calculation of Lemeshow. Multiple linear regression analysis method used SPSS 24 Software to analyze this research data. The results of the study include security fintech influence Sig. (0.005) on people's decisions to travel halal in Madura, infrastructure and brand image influence Sig. (<0.005) on people's decisions to travel halal in Madura. Based on these results, it encourages further research to analyze different factors that influence people's decisions in halal local tourism in Madura.
A ATUAÇÃO DO MÉDICO NA HUMANIZAÇÃO DOS CUIDADOS PALIATIVOS
Authors: Jarussi Mariana Benício 
Published: March 2024

Este trabalho aborda a importância do cuidado humanizado prestado pelo médico em cuidados paliativos. O objetivo é destacar a necessidade de uma abordagem que considere não apenas os aspectos físicos, mas também os emocionais, sociais e espirituais dos pacientes em fim de vida. Para isso, foi realizada uma revisão bibliográfica que abrangeu estudos e artigos que discutem a humanização no cuidado paliativo. Os resultados indicam que a humanização do cuidado médico nesse contexto contribui para uma melhor qualidade de vida dos pacientes e para uma morte mais digna. Conclui-se que a humanização do cuidado médico em cuidados paliativos é essencial para promover o bem-estar integral dos pacientes em fim de vida.
Primary Cold Agglutinin Disease Associated B Lymphoproliferative Neoplasm – A Case Report
Authors: Iberahim Salfarina , Abdullah Marne , Mohd Noor Noor Haslina , Zulkafli Zefarina , Abdullah Mohd Redzuan , Faizli Afif Alam , Nizam Akbar Nurul Asyikin , Wan Hanafi Hany Haqimi , Hussain Faezahtul Arbaeyah 
Published: March 2024

Cold autoimmune hemolytic anaemia (AIHA) has several causes, including Primary Cold Agglutinin (CAD). The cold AIHA in CAD is due to autoantibody anti-I. Most antibodies in cold AIHA are IgM subtype that optimally binds to red blood cells (RBCs) at 0°C–4°C. The presentation of the primary CAD is variable. Some patients presented with severe hemolytic anaemia and some incidentally had discrepancies in the laboratory results due to the cold agglutinin interferences. Here, we present a case of CAD secondary to clonal B Lymphoproliferative Disease (LPD). The patient presented with fever and had melaena. Upon blood taking for the investigations, the blood was easily clotted and his blood group showed discrepancy results forward and reverse.
Perianal Ulcer – A Rare Sequale of CMV Infection
Authors: A Aziz Muhammad Faiz , Ali Fatin Nur Afzan Afifah , Ab Rahim Mohd Fadliyazid 
Published: March 2024

Introduction: Cytomegalovirus (CMV) is a herpes-type virus. Most of the time, the virus produces mild or no symptoms in healthy people. However, in immunocompromised patient, serious CMV infections can occur. It can develop at any level along the gastrointestinal tract, but perianal ulcer is one of rare form of CMV manifestation. Case description: We presented case of a 33 years old gentleman presented with painless per rectal bleeding for 3 months’ duration. Physical examination revealed a near- circumferential perianal ulcer extending into the rectum. Colonoscopy showed no synchronous proximal lesion. During examination under anesthesia, the ulcer was shown to be extended until distal to dentate line. Wedge skin biopsy was performed with subsequent immunohistochemistry test was consistent with CMV infection. HIV serology test later was positive. Conclusion: Although it is rare, all immunocompromised patients with perianal ulcer should be suspected for CMV infection. Tissue biopsy is mandatory for confirmation of diagnosis. Antiviral therapy is the mainstay of treatment.
Keywords
Cytomegalovirus, Immunocompromised Patient, Ulcer, Anal
Antidiabetic Properties of Stingless Bee Pollen in High-Fat Diet FED-Low Dose STZ Induced Experimental T2DM Rats
Authors: Budi Setyawan Annaas 
Published: March 2024

Diabetes mellitus (DM) is a multisystem metabolic disease because of either insulin insufficiency or ineffectiveness. Individuals with DM continuously measure their blood glucose levels during fasting and after eating in order to manage their condition effectively. glucose levels during fasting and after eating in order to manage their condition effectively. Despite the availability of several drugs, there is no treatment proven to be perfect due to adverse side impacts as well as reduced long-term efficacy. Moreover, the excessive formation of free radicals has been linked to diabetes progression, development, as well as complications. As a result, there is a need to explore new medicines without side effects, preferably derived from natural products. Therefore, this study analyzes the antidiabetic properties of stingless bee pollen scientifically. This natural product was fed a high-fat diet and low streptozotocin doses in experimental rats with T2DM. An oral glucose tolerance test aimed investigate stingless bee pollen effect on glucose homeostasis. An insulin toleration test was executed to obtain stingless pollen influence on insulin sensitivity. This study measures Insulin resistance with HOMA-IR. Oral administration of stingless bee pollen for 30 days raised glucose homeostasis in T2DM rats, as shown by the OGTT, ITT, and HOMA-IR results. In addition, this treatment significantly improved changes in glycated hemoglobin, fasting blood glucose, protein, uric acid, urea, as well as creatinine levels. The activity changes of ALP, AST, and ALT liver enzyme markers in T2DM rats were nearly normalized after given with stingless bee pollen. The activity of carbohydrate metabolism enzymes includes pyruvate kinase, glucokinase, glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, fructose-1,6-bisphosphatase and lactate dehydrogenase in T2DM rats’ liver tissue. This change was significantly restored to near-normal levels after stingless bee pollen treatment.
Keywords: Diabetes Mellitus, High Fat Diet, Metformin, Stingless Bee Pollen
Challenges Confounding Biochemical Diagnosis of Acromegaly.
Authors: Md Muslim Mohd Zakwan , Tuan Ismail Tuan Salwani , Ab Rahim Siti Nadirah , Ibrahim Rahidatul Fairuz 
Published: March 2024

Abstract:
Acromegaly is a disorder caused by growth hormone (GH) hypersecretion resulting in excessive release of insulin like growth factor-1 (IGF-1). Both GH and IGF-1 measurements are crucial in its accurate diagnosis and in differentiating it from pseudoacromegaly. Early diagnosis is frequently restricted by its subtle, unnoticeable pathological changes; hence, clinical presentation is often late. Therefore, biochemical diagnosis is critical. However, the straightforward interpretation of these markers are hindered by factors that contribute to GH – IGF-1 discordance observed both in static and in dynamic function tests. These factors include both markers biological variation and their analytical assay limitations, which lead to false positive and negative results. This review is describing the pitfalls and challenges confounding the biochemical diagnosis of acromegaly. Despite these interpretive challenges, we strongly believe that interpretation of these results could be facilitated by effective clinician-laboratory professional communications which is the highlight of this review.

Keywords: Acromegaly, growth hormone (GH), insulin like growth factor-1 (IGF-1), IGF-binding proteins (IGFBP)
Evaluation of engraftment and growth dynamics of orthotopic and heterotopic in vivo models of human breast cancer
Authors: Lyashenko I. S. , Romanova M. V. , Goncharova A. S. , Khodakova D. V. , Galina A. V. , Gurova S. V. , Filippova S. Yu. , Shatova Yu. S. 
Published: March 2024

Purpose of the study. This work was to assess the engraftment and growth dynamics of breast cancer xenografts during orthotopic and subcutaneous injection using various types of biological material, as well as to develop an adequate model of breast cancer for further research.Materials and methods. We used a disaggregated fragment of a tumor obtained from the patient, a certified breast cancer cell line VT20 – human breast carcinoma; a primary human breast carcinoma cell line. Female immunodeficient mice of the Balb/c Nude line in the amount of 36 animals were used as recipient animals. The subcutaneous and orthotopic models of breast cancer were developed in this project. Tumor growth was observed for 28 days from the moment of injection and tumor nodes were measured 2 times a week until the end of the experiment. Results were assessed using medians and percentiles. The nonparametric Mann-Whitney test was used to assess the significance of differences.Results. The dynamics of the growth of tumor cells when injected into various sites was determined in the process of this work. The most successful in terms of a subcutaneous injection was the injection of tumor cells of the certified VT20 line. By the end of the experiment, the median tumor node of this group was 100.32 mm³. The analysis revealed tumor dynamics with orthotopic injection of tumor material, and the median volume of the tumor node in the group with the passport culture cell VT20 and the primary culture cell reached the same value – 149.22 and 148.25. mm³. It was found that both the cell line and the cell suspension were injected into tumor nodes that reached a significantly larger volume when injected orthotopically.Conclusion. We have obtained a tumor model of breast cancer using various methods of material implantation and with the possibility of further use in testing new pharmacological substances.
Metastatic lesions of the uterus, fallopian tubes and ovaries in undifferentiated pleomorphic sarcoma of the left tibia (clinical case)
Authors: Kit O. I. , Verenikina E. V. , Menshenina A. P. , Vladimirova L. Yu. , Kalabanova E. A. , Lapteva T. O. , Barashev A. A. , Eremin K. S. , Ardzha A. Yu. 
Published: March 2024

Undifferentiated pleomorphic osteosarcoma belongs to the group of rarely occurring tumors. Despite the treatment, the disease progresses in 30–40 % of patients with osteosarcomas. The main route of metastasis of bone tissue sarcomas is hematogenous, while lymphogenic spread is observed less frequently. As a rule, secondary metastatic changes occur in the lungs. Less often there is a secondary lesion of the bones of the skeleton and brain. Metastatic lesion of uterus, fallopian tubes and ovaries in malignant undifferentiated pleomorphic sarcoma is extremely rare. Therefore, we found it interesting to describe a clinical case of such a rare metastatic lesion. Patient K. underwent amputation of the left limb at the level of the lower third of the femur for undifferentiated pleomorphic sarcoma of the left tibia in 2019, and 4 courses of adjuvant polychemotherapy were performed. In 20 months after completion of complex treatment of the primary tumor, complaints of lower abdominal pain, increased body temperature up to 37.8 °C in the evenings appeared. According to the results of follow-up examination, a voluminous, multinodular, solid mass of merging character was detected in the pelvis, with total dimensions of up to 11 cm, and a cavitary mass of up to 5 cm was detected in the posterior vault. A trepan-biopsy of the mass in the projection of the right ovary was performed. The morphological picture in the volume of trepan biopsy specimens is characteristic of spindle cell sarcoma. Metastasis of undifferentiated pleomorphic bone sarcoma (malignant fibrous histiocytoma) is most likely. Due to metastatic lesions of the uterus, fallopian tubes, ovaries, omentum, mesentery and serous membrane of the colon loops, peritoneum of the bladder, surgical intervention in the volume of removal of the distal part of the sigmoid colon, rectosigmoid, upper ampullary parts of the rectum, uterus with fallopian tubes and ovaries, appendix was performed. Immunohistochemical study of the postoperative material revealed that the immunophenotype of tumor cells confirmed the morphological picture typical for undifferentiated pleomorphic bone sarcoma. The patient was further prescribed antitumor drug therapy. This clinical case demonstrates a rare, atypical metastasis of undifferentiated pleomorphic osteosarcoma, which allows to expand the knowledge about the flow of malignant diseases of this localization.
Mitochondrial transplantation: new challenges for cancer
Authors: Kit O. I. , Frantsiyants E. M. , Shikhlyarova A. I. , Neskubina I. V. 
Published: March 2024

This review discusses the uniqueness of mitochondria providing normal cellular functions and at the same time involved in many pathological conditions, and also analyzes the scientific literature to clarify the effectiveness of mitochondrial transplantation in cancer treatment. Being important and semi-autonomous organelles in cells, they are able to adapt their functions to the needs of the corresponding organ. The ability of mitochondria to reprogram is important for all cell types that can switch between resting and proliferation. At the same time, tumor mitochondria undergo adaptive changes to accelerate the reproduction of tumor cells in an acidic and hypoxic microenvironment. According to emerging data, mitochondria can go beyond the boundaries of cells and move between the cells of the body. Intercellular transfer of mitochondria occurs naturally in humans as a normal mechanism for repairing damaged cells. The revealed physiological mitochondrial transfer has become the basis for a modern form of mitochondrial transplantation, including autologous (isogenic), allogeneic, and even xenogenic transplantation. Currently, exogenous healthy mitochondria are used in treatment of several carcinomas, including breast cancer, pancreatic cancer, and glioma. Investigation of the functional activity of healthy mitochondria demonstrated and confirmed the fact that female mitochondria are more efficient in suppressing tumor cell proliferation than male mitochondria. However, tissue-specific sex differences in mitochondrial morphology and oxidative capacity were described, and few studies showed functional sex differences in mitochondria during therapy. The reviewed studies report that mitochondrial transplantation can be specifically targeted to a tumor, providing evidence for changes in tumor function after mitochondrial administration. Thus, the appearance of the most interesting data on the unique functions of mitochondria indicates the obvious need for mitochondrial transplantation.
La relation migration-développement au prisme des localités : rétrospective d’une tension continue entre politisation et dépolitisation au Mali
Authors: Lima Stéphanie 
Published: March 2024

La relation migration-développement s’est construite sur plusieurs mythes, déconstruits mais réalimentés jusqu’à présent. Mis à l’agenda global dans le milieu des années 2000, ce nexus s’est banalisé, masquant les chemins rugueux empruntés par les acteurs incarnant cette interrelation, pour faire advenir leur légitimité dans le champ du développement. À travers une lecture diachronique, cet article revisite cette relation au prisme des espaces locaux, les villages de départ, dans la région Kayes au Mali. Puisant sa matière dans une longue temporalité, il interroge les formes évolutives de cette relation et les dynamiques de politisation et de dépolitisation aux échelles locale et nationale. Les pratiques originales des associations de développement des migrants ont façonné des territoires particuliers, leur conférant une reconnaissance a posteriori. Après avoir revendiqué un engagement apolitique, elles sont devenues des contre-pouvoirs. Ainsi les résultats proposés éclairent la complexité et les remous politiques de la relation migration-développement, bien éloignés du tableau lisse, mis en avant par les institutions dominantes.
RANCANG BANGUN APLIKASI ABSENSI GURU DAN STAF TU DENGAN PENERAPAN GEOLOCATION DAN FINGERPRINT BERBASIS ANDROID DI SMK GKE MANDOMAI
Authors: Berkati Axel , Licantik  , Nugrahaningsih Nahumi , Lestari Ariesta , Sylviana Felicia 
Published: March 2024

Attendance is one of the work assessments and as proof of attendance is very important. At this time, the attendance system used by SMK GKE Mandomai is still implementing a manual attendance system, which is every day to sign at every date of entry to work, and attendance is done 2 times, namely entry attendance and return attendance.
This manual attendance system has the potential to cause some problems, such as attendance papers that are easily lost or scattered and the possibility of manipulating attendance data.
As a solution, namely by designing an attendance application with the application of geolocation and fingerprint on android as security when doing absences, in order to prevent teachers and TU staff who are outside the school location to fill absences. The development method used in designing this system is the Waterfall model with its stages, namely Software Requirements Analysis, Design, Coding, and testing. System design using UML model, implement coding using JavaScript, React Native framework and React JS, backend using Firebase. the results of this system design, produce Android-based attendance system for teachers and staff TU attendance in school areas.
MFI Zeolite Membranes and PV Separation of Isopropanol-Water Azeotropic Mixtures
Authors: A.A. Kittur  
Published: March 2024

Membrane separation process has become one of the emerging technologies that undergo a rapid growth since few decades. Pervaporation (PV) is one among the membrane separation processes which gained foremost interest in the chemical and allied industries. It is an effective and energy-efficient technology that carries out separations, which are difficult to achieve by conventional separation processes. Inorganic membranes such as zeolite membranes with uniform, molecular-sized pores, selective adsorption and molecular sieving action offer unique type of pervaporation membrane for a number of separation processes. This paper presents the role of MFI-zeolite membrane and its progress in the pervaporation process. The fundamental aspects of pervaporation over different types of membranes are reviewed and compared. The focus of this paper is on zeolite membrane synthesis, membrane characterization and pervaporation studies. The transport mechanism during pervaporation is discussed and the issues related with pervaporation are addressed. Innovation and future development of zeolite membrane in pervaporation are also presented.
Nurturing Development Administration in South African Local Government
Authors: Maela K. D , Matloga S. T , Zitha H. E 
Published: March 2024

This paper aims to unpack the relationship between the development administration and local government in fostering socio-economic development. the paper argues that the effective implementation of the development administration sufficiently contributes to local government productivity in delivering government development-oriented services and programs. Development administration includes strengthening administrative capabilities. Development administration covers a wide range of techniques used by large organizations, most notably the government to implement plans and policies that are meant to assist them in achieving their developmental objectives. The main goal of development administration is to create a better social, political, and economic environment. The local government plays a crucial role in Africa's economic development trajectory. the paper is conceptual in nature as relies heavily on secondary data and existing literature to address the answer to the inherent argument. from the literature, authors derived findings such as a lack of adequate political capability and politicization of development, corruption, lack of accountability, low priority of quality assurance, poor monitoring, and evaluation of socioeconomic policies, excessive political control, poor capacity development, nepotism, lack of community participation, resources constraints, inter alia. the study recommends that further research should be conducted in all municipalities within South Africa to detect the problem associated with development administration for effective enhancement of socio-economic development as well as reinforcing and easing the sustainable development in local government. since public administration is regarded as a social science discipline the study contributes to the field of public administration and development as it deals with assessing and resolving the social, political, and economic problems that affect day to day life of communities. Development administration also contributes to the National Development Plan as it enhances the social, political, and economic arena. the study can also influence public officials to be equipped with more skills to meet the socio-economic needs of the communities.