bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary Phytoestrogens Activate AMP-Activated Protein Kinase With Improvement in Lipid and Glucose Metabolism
Authors: Cederroth Christopher R. , Vinciguerra Manlio , Gjinovci Asllan , Kühne Françoise , Klein Marcella , Cederroth Manon , Caille Dorothée , Suter Mariane , Neumann Dietbert , James Richard W. , Doerge Daniel R. , Wallimann Theo , Meda Paolo , Foti Michelangelo , Rohner-Jeanrenaud Françoise , Vassalli Jean-Dominique , Nef Serge 
Published: April 2008

OBJECTIVE— Emerging evidence suggests that dietary phytoestrogens can have beneficial effects on obesity and diabetes, although their mode of action is not known. Here, we investigate the mechanisms mediating the action of dietary phytoestrogens on lipid and glucose metabolism in rodents.
RESEARCH DESIGN AND METHODS— Male CD-1 mice were fed from conception to adulthood with either a high soy–containing diet or a soy-free diet. Serum levels of circulating isoflavones, ghrelin, leptin, free fatty acids, triglycerides, and cholesterol were quantified. Tissue samples were analyzed by quantitative RT-PCR and Western blotting to investigate changes of gene expression and phosphorylation state of key metabolic proteins. Glucose and insulin tolerance tests and euglycemic-hyperinsulinemic clamp were used to assess changes in insulin sensitivity and glucose uptake. In addition, insulin secretion was determined by in situ pancreas perfusion.
RESULTS— In peripheral tissues of soy-fed mice, especially in white adipose tissue, phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase was increased, and expression of genes implicated in peroxisomal fatty acid oxidation and mitochondrial biogenesis was upregulated. Soy-fed mice also showed reduced serum insulin levels and pancreatic insulin content and improved insulin sensitivity due to increased glucose uptake into skeletal muscle. Thus, mice fed with a soy-rich diet have improved adipose and glucose metabolism.
CONCLUSIONS— Dietary soy could prove useful to prevent obesity and associated disorders. Activation of the AMPK pathway by dietary soy is likely involved and may mediate the beneficial effects of dietary soy in peripheral tissues.
Hyperglycemia-Induced Reactive Oxygen Species Toxicity to Endothelial Cells Is Dependent on Paracrine Mediators
Authors: Busik Julia V. , Mohr Susanne , Grant Maria B. 
Published: April 2008

OBJECTIVE—This study determined the effects of high glucose exposure and cytokine treatment on generation of reactive oxygen species (ROS) and activation of inflammatory and apoptotic pathways in human retinal endothelial cells (HRECs).
RESEARCH DESIGN AND METHODS—Glucose consumption of HRECs, human retinal pigment epithelial cells (HRPEs), and human Müller cells (HMCs) under elevated glucose conditions was measured and compared with cytokine treatment. Production of ROS in HRECs was examined using 5-(and-6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate (CM-H2DCFDA), spin-trap electron paramagnetic resonance, and MitoTracker Red staining after high glucose and cytokine treatment. The activation of different signaling cascades, including the mitogen-activated protein kinase pathways, tyrosine phosphorylation pathways, and apoptosis by high glucose and cytokines in HRECs, was determined.
RESULTS—HRECs, in contrast to HRPEs and HMCs, did not increase glucose consumption in response to increasing glucose concentrations. Exposure of HRECs to 25 mmol/l glucose did not stimulate endogenous ROS production, activation of nuclear factor-κB (NF-κB), extracellular signal–related kinase (ERK), p38 and Jun NH2-terminal kinase (JNK), tyrosine phosphorylation, interleukin (IL)-1β, or tumor necrosis factor-α (TNF-α) production and only slightly affected apoptotic cell death pathways compared with normal glucose (5 mmol/l). In marked contrast, exposure of HRECs to proinflammatory cytokines IL-1β or TNF-α increased glucose consumption, mitochondrial superoxide production, ERK and JNK phosphorylation, tyrosine phosphorylation, NF-κB activation, and caspase activation.
CONCLUSIONS—Our in vitro results indicate that HRECs respond to cytokines rather than high glucose, suggesting that in vivo diabetes–related endothelial injury in the retina may be due to glucose-induced cytokine release by other retinal cells and not a direct effect of high glucose.
MAPK Kinase Kinase-1 Is Essential for Cytokine-Induced c-Jun NH2-Terminal Kinase and Nuclear Factor-κB Activation in Human Pancreatic Islet Cells
Authors: Mokhtari Dariush , Myers Jason W. , Welsh Nils 
Published: April 2008

OBJECTIVE—The transcription factor nuclear factor-κB (NF-κB) and the mitogen-activated protein kinases (MAPKs) c-Jun NH2-terminal kinase (JNK) 1/2 are known to play decisive roles in cytokine-induced damage of rodent β-cells. The upstream events by which these factors are activated in response to cytokines are, however, uncharacterized. The aim of the present investigation was to elucidate a putative role of the MAPK kinase kinase-1 (MEKK-1) in cytokine-induced signaling.RESEARCH DESIGN AND METHODS—To establish a functional role of MEKK-1, the effects of transient MEKK-1 overexpression in βTC-6 cells, achieved by lipofection and cell sorting, and MEKK-1 downregulation in βTC-6 cells and human islet cells, achieved by diced–small interfering RNA treatment, were studied.RESULTS—We observed that overexpression of wild-type MEKK-1, but not of a kinase dead MEKK-1 mutant, resulted in potentiation of cytokine-induced JNK activation, inhibitor of κB (IκB) degradation, and cell death. Downregulation of MEKK-1 in human islet cells provoked opposite effects, i.e., attenuation of cytokine-induced JNK and MKK4 activation, IκB stability, and a less pronounced NF-κB translocation. βTC-6 cells with a downregulated MEKK-1 expression displayed also a weaker cytokine-induced iNOS expression and lower cell death rates. Also primary mouse islet cells with downregulated MEKK-1 expression were protected against cytokine-induced cell death.CONCLUSIONS—MEKK-1 mediates cytokine-induced JNK- and NF-κB activation, and this event is necessary for iNOS expression and cell death.
Influence of Light-polymerization Modes on the Degree of Conversion and Mechanical Properties of Resin Composites: A Comparative Analysis Between a Hybrid and a Nanofilled Composite
Authors: da Silva E. M. , Poskus L. T. , Guimarães J. G. A. 
Published: April 2008

Clinical Relevance
The nanofilled composite presented a lower degree of conversion, flexural modulus and flexural strength than the hybrid composite. On the other hand, the two materials had a similar hardness. The light polymerization mode influenced only the degree of conversion and the hardness of composites.
Evaluation of Light Transmission Through Translucent and Opaque Posts
Authors: Galhano GÁ , de Melo R. M. , Barbosa S. H. , Zamboni S. C. , Bottino M. A. , Scotti R. 
Published: April 2008

Clinical Relevance
The resin cement polymerization inside the root is decreased, because transmission of light in the apical direction is difficult. This study suggests that the use of translucent posts presents advantages in relation to the opaque posts, however, both do not allow polymerization in the apical region.
Robust fault detection and isolation for LPV systems under a sensitivity constraint
Authors: Armeni Saverio , Casavola Alessandro , Mosca Edoardo 
Published: April 2008

AbstractA novel fault detection and isolation (FDI) filter design method is proposed for linear parameter varying (LPV) systems. The LPV system description can be used to approximate the behavior of nonlinear systems and leads to simple nonlinear FDI designs. The main goal here is to obtain residual generator (RG) filters with enhanced fault transmission dc‐gains and large ℋ︁∞nuisance attenuation. This is achieved using bilinear matrix inequality techniques by exploiting the relevant geometrical properties of the affine LPV description. Finally, it is shown by a nonlinear example that the RG filters designed by the proposed method compare well with alternative approaches including direct nonlinear design methods. Copyright © 2008 John Wiley & Sons, Ltd.
Enhancement of Electrical Properties of Ferroelectric Polymers by Polyaniline Nanofibers with Controllable Conductivities
Authors: Wang Chang‐Chun , Song Jiao‐Fan , Bao Hui‐Min , Shen Qun‐Dong , Yang Chang‐Zheng 
Published: April 2008

AbstractConductive nanofibers are adopted to enhance the electric properties of ferroelectric polymers. Polyaniline (PANI) nanofibers doped by protonic acids have a high dispersion stability in vinylidene fluoride‐trifluoroethylene copolymers [P(VDF‐TrFE)] and lead to percolative nanocomposites with enhanced electric responses. About a 50‐fold rise in the dielectric constant of the ferroelectric polymer matrix has been achieved. Percolation thresholds of the nanocomposites are relevant to doping levels of PANI nanofibers and can be as low as 2.9 wt% for fully doped nanofibers. The interface between the conductive nanofiber and the polymer matrix plays a crucial role in the dielectric enhancement of the nanocomposites in the vicinity of the percolation threshold. Compared with other dopants, perfluorosulfonic acid resin is better at improving the performance of the nanofibers in that it serves as a surface passivation layer for the conductive fillers and suppresses leakage current at low frequency. The nanofibers drastically reduce the electric field strength required to switch spontaneous polarization of P(VDF‐TrFE). The nanocomposites can be utilized for potential applications as high energy density capacitors, thin‐film transistors, and non‐volatile ferroelectric memories.
Dyeing properties of wool fabrics treated with atmospheric pressure plasmas
Authors: Cai Zaisheng , Qiu Yiping 
Published: April 2008

AbstractThe dyeing properties of wool treated with atmospheric pressure plasma are investigated in terms of exhaustion with dyeing time, absorption isotherm and Ct/C∞ versus t1/2 curves, dyeing rate (half‐dyeing time), exhaustion at dyeing equilibrium, and color fastnesses. The wettablity and surface morphology of the plasma‐treated wool are also analyzed. Through both air/helium and oxygen/helium atmospheric pressure plasma treatments, the water contact angle of the fabric decreases from 132.4° to 0° and water penetration time drops from more than 2000 s to 1 s or 2 s. The scanning electron microscopy analysis shows etching and crack marks on treated fiber surfaces. The plasma treatments greatly increase initial dyeing rate, shorten half‐dyeing time, t1/2, and the time to reach dyeing equilibrium, although the final exhaustion and color fastnesses do not change. The Langmuir adsorption equation is also valid for the plasma‐treated wools dyed with an acid dye. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
PdII and PtII Complexes with Amphiphilic Ligands: Formation of Micelles and [5]Rotaxanes with α‐Cyclodextrin in Aqueous Solution
Authors: Taira Toshiaki , Suzaki Yuji , Osakada Kohtaro 
Published: April 2008

Abstract[3]Pseudorotaxanes [1(α‐CD)2][X] (X=Cl, NO3), prepared from reaction of an N‐alkylbipyridinium [4,4′‐bpy‐N‐(CH2)10OC6H3‐3,5‐(OMe)2][X] ([1][X]) and α‐CD, react with M(NO3)2(en) (M=Pd, Pt; en=1,2‐ethylenediamine) in a 2:1 molar ratio to afford [5]rotaxanes [M{(4,4′‐bpy‐N‐(CH2)10OC6H3‐3,5‐(OMe)2)(α‐CD)2}2 (en)][NO3]4 ([2(α‐CD)4][NO3]4, M=Pd; [3(α‐CD)4][NO3]4, M=Pt). A similar reaction of [1][Cl] with [M(NO3)2(en)] (M=Pd, Pt) produces amphiphilic Pd and Pt complexes, [2][NO3]4 and [3][NO3]4. Complexes [2][NO3]4 and [3][NO3]4 form micelles in the presence of small amounts of dyes (Nile red and pyrene) in water. The critical micelle concentration (CMC) was determined by the absorption peak of the dye, which is encapsulated in the micelles in solution. Micelle formation is confirmed by dynamic light scattering measurement of the solution and TEM (transmission electron microscopy) images of the micelles deposited from the solution. Addition of α‐CD to the aqueous solution containing these amphiphilic complexes results in degradation of the micelle structure and the formation of [5]rotaxanes, [2(α‐CD)4][NO3]4 and [3(α‐CD)4][NO3]4.
Forecast impact experiment with a constellation of GPS radio occultation receivers
Authors: Healy S. B. 
Published: April 2008

AbstractA forecast impact experiment with a constellation of global positioning system radio occultation (GPSRO) receivers is presented. The constellation includes the six COSMIC/FORMO‐ SAT‐3 satellites, combined with the GRACE‐A and CHAMP satellites. It is shown that rising and setting occultations measured with the COSMIC satellites have similar bending angle error characteristics. The GPSRO measurements improve the root mean square (rms) geopotential height forecast errors at 500, 200, and 100 hPa in both the Northern and Southern Hemispheres. The forecast fit to radiosonde temperature measurements in the Stratosphere is also improved. Copyright © 2008 Royal Meteorological Society
A high‐resolution modelling case study of a severe weather event over New Zealand
Authors: Webster Stuart , Uddstrom Michael , Oliver Hilary , Vosper Simon 
Published: April 2008

AbstractIn this article, the ability of the Met Office Unified Model to simulate the severe weather over the South Island of New Zealand, on 8 January 2004 is investigated. Simulations were run at horizontal resolutions of between 60 and 1 km. The modelled broad‐scale rainfall and wind features, most notably the area‐averaged accumulated rainfall, were found to converge with resolution. At the highest resolutions, all the observed rainfall and wind features of this event were captured well by the model. Even the 12‐km‐resolution model is able to resolve the broad elongated ridge‐like structure of the Southern Alps and qualitatively capture the main features of the rainfall and wind fields. Copyright © 2008 Royal Meteorological Society and Crown Copyright 2008, published by John Wiley & Sons, Ltd.
Interaction of Isoquinoline Alkaloid Palmatine with Deoxyribonucleic Acids: Binding Heterogeneity, and Conformational and Thermodynamic Aspects
Authors: Bhadra Kakali , Maiti Motilal , Kumar Gopinatha Suresh 
Published: April 2008

AbstractThe binding heterogeneity, conformational aspects, and energetics of the interaction of the cytotoxic plant alkaloid palmatine have been studied with various natural and synthetic DNAs. The alkaloid binds to calf thymus and Escherichia coli DNA that have mixed AT and GC sequences in almost equal proportions with positive cooperativity, while, with Clostridium perfringens and Micrococcus lysodeikticus DNA with predominantly high AT and GC sequences, respectively, noncooperative binding was observed. On further investigation with synthetic DNAs, the binding was observed to be cooperative with polymers like poly(dA)⋅poly(dT) and poly(dG)⋅poly(dC) having poly(purine)⋅poly(pyrimidine) sequences, while with polymers poly(dA‐dT)⋅poly(dA‐dT), poly(dA‐dC)⋅poly(dG‐dT) and poly(dG‐dC)⋅poly(dG‐dC), which have alternating purine‐pyrimidine sequences, a non‐cooperative binding phenomenon was observed. This suggests the binding heterogeneity of palmatine to the two types of sequences of base pairs. Circular dichroism (CD) studies revealed that the binding induced conformational changes in all the DNAs, but more importantly, the bound alkaloid molecules acquired induced optical activity, and the extent was dependent on the AT content and showed AT base‐pair specificity. Energetics of the interaction of the alkaloid studied by highly sensitive isothermal titration calorimetry revealed that the binding was in most cases exothermic and favored by both enthalpy and entropy changes, while, in the case of the homo and hetero AT polymers, the same was predominantly entropy‐driven. This study defines base‐pair‐dependent heterogeneity, conformational aspects, and energetics of palmatine binding to DNA.
ChemInform Abstract: Stability of Alkali Metal Halide Polymorphs as a Function of Pressure
Authors: Cancarevic Zeljko P. , Schoen J. Christian , Jansen Martin 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Vibrational Property Study of SrGa2H2 and BaGa2H2 by Inelastic Neutron Scattering and First Principles Calculations.
Authors: Lee Myeong H. , Evans Michael J. , Daemen Luke L. , Sankey Otto F. , Haeussermann Ulrich 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Crystal Structure, and Luminescence Properties of a Novel Green‐Yellow Emitting Phosphor LiZn1‐xPO4:Mnx for Light Emitting Diodes.
Authors: Chan Ting‐Shan , Liu Ru‐Shi , Baginskiy Ivan 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Two‐Dimensional Superdegeneracy and Structure—Magnetism Correlations in Strong Ferromagnet, Mn2Ga5.
Authors: Kim Sang‐Hwan , Bostroem Magnus , Seo Dong‐Kyun 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Lanthanoid(III) Chloride Oxoselenates(IV) LnCl[SeO3] (Ln: Sm—Lu) with HoCl[TeO3]‐ or B‐Type Structure.
Authors: Lipp Christian , Schleid Thomas 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Synthesis of Heterocyclic β‐Aminoalcohols Catalyzed by a Samarium Iodo Binaphtholate.
Authors: Martin Myriam , Bezzenine‐Lafollee Sophie , Gil Richard , Collin Jacqueline 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Controlled Conversion of Phenylacetic Acids to Phenylacetonitriles or Benzonitriles Using Bis(2‐methoxyethyl)aminosulfur Trifluoride.
Authors: Kangani Cyrous O. , Day Billy W. , Kelley David E. 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Convergent Synthesis of Polysubstituted Aromatic Nitriles via Palladium‐Catalyzed C—H Functionalization.
Authors: Mariampillai Brian , Alliot Julien , Li Mengzhou , Lautens Mark 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ceric Ammonium Nitrate (CAN) Promoted Efficient Solid Phase Synthesis of Amide Derivatives: A Green Approach.
Authors: Reddy Ch. Sanjeeva , Raghu M. , Nagaraj A. 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diastereoselective Synthesis of Three‐, Five‐, Six‐, and Seven‐Membered Rings from Fischer Carbene Complexes and 4‐Unsubstituted 1‐Amino‐1,3‐dienes.
Authors: Aznar Fernando , Fananas‐Mastral Martin , Alonso Jorge , Fananas Francisco J. 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of Acetylene with 2‐(2‐Aminoethylamino)ethanol.
Authors: Kukharev B. F. , Stankevich V. K. , Lobanova N. A. , Stankevich V. V. , Kukhareva V. A. 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Evaluation of Enantiopure N‐(Ferrocenylmethyl)azetidin‐2‐yl(diphenyl)methanol for Catalytic Asymmetric Addition of Organozinc Reagents to Aldehydes.
Authors: Wang Min‐Can , Zhang Qing‐Jian , Zhao Wen‐Xian , Wang Xiao‐Dan , Ding Xue , Jing Tao‐Tao , Song Mao‐Ping 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Application for PyOX‐Ligands: The Asymmetric Henry Reaction.
Authors: Oila Markku J. , Tois Jan E. , Koskinen Ari M. P. 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave‐Assisted Ring‐Opening of Epoxides with N‐Biaryl Sulfonamides in the Synthesis of Matrix Metalloproteinase‐9 Inhibitors.
Authors: Yang Shyh‐Ming , Murray William V. 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Mesomorphic Properties of Esters Derived from Alkanediols.
Authors: Maksimenko S. I. , Novikova N. S. , Kondrat'eva R. V. , Kuz'min V. E. , Ognichenko L. N. , Yarkova M. Yu. 
Published: April 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.