bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal immune suppression during pregnancy does not prevent abnormal behavior in offspring
Authors: Griffin Ashley , Bowles Teylor , Solis Lucia , Railey Teryn , Beauti Samer , Robinson Reanna , Spencer Shauna-Kay , Shaffery James P , Wallace Kedra 
Published: March 2024

Abstract
Background
Offspring of hypertensive disorders of pregnancy are at an increased risk of developing neurodevelopmental and neurobehavioral disorders compared to offspring from non-affected pregnancies. Using rodent models of Preeclampsia (PreE; new onset of hypertension after 20 weeks gestation) and HELLP (hemolysis, elevated liver enzymes, and low platelets), we studied the behavioral outcome of their offspring in adolescence.

Methods
A subset of dams received Orencia, a T-cell activation inhibitor, as T cells have been associated with the induction of hypertension and inflammation during pregnancy. We hypothesized that offspring from hypertensive dams would experience adverse behavioral outcomes in social, cognitive, locomotor, and anxiety tests, and offspring from dams treated with Orencia would demonstrate less adverse behaviors.

Results
Male offspring of PreE + Orencia dams (p < 0.05) and female offspring from HELLP + Orencia dams (p < 0.05) spent more time playing compared to normal pregnant offspring. All offspring from hypertensive and Orencia-treated dams performed worse on the Barnes Maze test compared to normal pregnant. We also measured adult (postnatal day > 60) myelin basic protein (MBP) and NeuN expression in both the prefrontal cortex and hippocampus. In the hippocampus and prefrontal cortex, there was no difference in expression of either MBP or NeuN in all groups regardless of sex.

Conclusion
The results from this study suggest that offspring of hypertensive disorders of pregnancy have behavioral changes, specifically cognitive differences. This study has shown that there is a sex dependent difference in offspring neurobehavioral development, influenced in part by the type of hypertensive disorder of pregnancy, and alterations in the maternal immune system.
Epidemiological characterization and risk assessment of rabbit haemorrhagic disease virus 2 (RHDV2/b/GI.2) in the world
Authors: Sun Zhuo , An Qi , Li Yuepeng , Gao Xiang , Wang Hongbin 
Published: March 2024

AbstractA novel variant of rabbit haemorrhagic disease virus, designated RHDV2/b/GI.2, was first discovered in France in 2010. Subsequently, RHDV2 rapidly spread to Africa, North America, Australia, and Asia. RHDV2 outbreaks have resulted in significant economic losses in the global rabbit industry and disrupted the balance of natural ecosystems. Our study investigated the seasonal characteristics of RHDV2 outbreaks using seasonal indices. RHDV2 is prone to causing significant outbreaks within domestic and wild rabbit populations during the spring season and is more likely to induce outbreaks within wild rabbit populations during late autumn in the Southern Hemisphere. Furthermore, based on outbreak data for domestic and wild rabbits and environmental variables, our study established two MaxEnt models to explore the relationship between RHDV2 outbreaks and the environmental factors and conducted outbreak risk predictions for RHDV2 in global domestic and wild rabbit populations. Both models demonstrated good predictive performance, with AUC values of 0.960 and 0.974, respectively. Road density, isothermality, and population density were identified as important variables in the outbreak of RHDV2 in domestic rabbits, while road density, normalized difference vegetation index, and mean annual solar radiation were considered key variables in the outbreak of RHDV2 in wild rabbits. The environmental factors associated with RHDV2 outbreaks identified in our study and the outbreak risk prediction maps generated in our study will aid in the formulation of appropriate RHDV2 control measures to reduce the risk of morbidity in domestic and wild rabbits.
3D scanning and modeling of highly detailed and geometrically complex historical architectural objects: the example of the Juma Mosque in Khiva (Uzbekistan)
Authors: Milosz Marek , Kęsik Jacek , Abdullaev Utkir 
Published: March 2024

Abstract
The city centre of Khiva (Uzbekistan), called Itchan Kala, is an architectural complex included in the UNESCO list of tangible cultural heritage. One of the historic buildings in it is the Juma Mosque. It has a simple rectangular structure, but is very large and has 213 deeply carved wooden columns supporting the roof. The article presents the process, problems, and their solutions resulting from the implementation of 3D laser scanning of such highly detailed and geometrically complex historical architectural objects in the conditions of normal tourist traffic. The optimisation of scanning positions, scanning in situ implementation, as well as the processing of the acquired data and the construction of a 3D mesh model of the mosque interior are presented. It is pointed out that scanning such objects with high accuracy and density of measurement points causes major technical problems related to the workload, and the huge volume of data acquired and processed. The possibilities of making the 3D model available in digital space for the purpose of researching the appearance and geometry of the mosque, its individual columns, as well as popularising the monument are also discussed. It is highly probable that the scanning of the Juma Mosque's interior presented here was carried out for the first time in history.
A hierarchical fusion strategy of deep learning networks for detection and segmentation of hepatocellular carcinoma from computed tomography images
Authors: Lee I-Cheng , Tsai Yung-Ping , Lin Yen-Cheng , Chen Ting-Chun , Yen Chia-Heng , Chiu Nai-Chi , Hwang Hsuen-En , Liu Chien-An , Huang Jia-Guan , Lee Rheun-Chuan , Chao Yee , Ho Shinn-Ying , Huang Yi-Hsiang 
Published: March 2024

Abstract
Background
Automatic segmentation of hepatocellular carcinoma (HCC) on computed tomography (CT) scans is in urgent need to assist diagnosis and radiomics analysis. The aim of this study is to develop a deep learning based network to detect HCC from dynamic CT images.

Methods
Dynamic CT images of 595 patients with HCC were used. Tumors in dynamic CT images were labeled by radiologists. Patients were randomly divided into training, validation and test sets in a ratio of 5:2:3, respectively. We developed a hierarchical fusion strategy of deep learning networks (HFS-Net). Global dice, sensitivity, precision and F1-score were used to measure performance of the HFS-Net model.

Results
The 2D DenseU-Net using dynamic CT images was more effective for segmenting small tumors, whereas the 2D U-Net using portal venous phase images was more effective for segmenting large tumors. The HFS-Net model performed better, compared with the single-strategy deep learning models in segmenting small and large tumors. In the test set, the HFS-Net model achieved good performance in identifying HCC on dynamic CT images with global dice of 82.8%. The overall sensitivity, precision and F1-score were 84.3%, 75.5% and 79.6% per slice, respectively, and 92.2%, 93.2% and 92.7% per patient, respectively. The sensitivity in tumors < 2 cm, 2–3, 3–5 cm and > 5 cm were 72.7%, 92.9%, 94.2% and 100% per patient, respectively.

Conclusions
The HFS-Net model achieved good performance in the detection and segmentation of HCC from dynamic CT images, which may support radiologic diagnosis and facilitate automatic radiomics analysis.
Habitat-based radiomics analysis for evaluating immediate response in colorectal cancer lung metastases treated by radiofrequency ablation
Authors: Huang Haozhe , Chen Hong , Zheng Dezhong , Chen Chao , Wang Ying , Xu Lichao , Wang Yaohui , He Xinhong , Yang Yuanyuan , Li Wentao 
Published: March 2024

Abstract
Purpose
To create radiomics signatures based on habitat to assess the instant response in lung metastases of colorectal cancer (CRC) after radiofrequency ablation (RFA).

Methods
Between August 2016 and June 2019, we retrospectively included 515 lung metastases in 233 CRC patients who received RFA (412 in the training group and 103 in the test group). Multivariable analysis was performed to identify independent risk factors for developing the clinical model. Tumor and ablation regions of interest (ROI) were split into three spatial habitats through K-means clustering and dilated with 5 mm and 10 mm thicknesses. Radiomics signatures of intratumor, peritumor, and habitat were developed using the features extracted from intraoperative CT data. The performance of these signatures was primarily evaluated using the area under the receiver operating characteristics curve (AUC) via the DeLong test, calibration curves through the Hosmer-Lemeshow test, and decision curve analysis.

Results
A total of 412 out of 515 metastases (80%) achieved complete response. Four clinical variables (cancer antigen 19–9, simultaneous systemic treatment, site of lung metastases, and electrode type) were utilized to construct the clinical model. The Habitat signature was combined with the Peri-5 signature, which achieved a higher AUC than the Peri-10 signature in the test set (0.825 vs. 0.816). The Habitat+Peri-5 signature notably surpassed the clinical and intratumor radiomics signatures (AUC: 0.870 in the test set; both, p < 0.05), displaying improved calibration and clinical practicality.

Conclusions
The habitat-based radiomics signature can offer precise predictions and valuable assistance to physicians in developing personalized treatment strategies.
The Late Effects of Hematopoietic Stem Cell Transplants in Pediatric Patients: A 25-Year Review
Authors: Lee Samantha Lai-Ka , Nguyen Quynh-Nhu , Ho Cindy , James Simon , Kaur Amreeta , Lim Angelina , Tiedemann Karin , Zacharin Margaret 
Published: March 2024

Abstract

Context
A rare, large, single-center study covering all long-term health outcomes of pediatric allogeneic hemopoietic stem cell transplant (HSCT) survivors, to provide comprehensive local data and identify gaps and future directions for improved care.

Objective
To document endocrine sequelae and other late effects of all HSCT recipients.

Design
Retrospective review.

Setting
Royal Children's Hospital Melbourne.

Patients
384 children and adolescents received HSCT; 228 formed the study cohort; 212 were alive at commencement of data accrual.

Intervention
None.

Main Outcome Measures
Incidence of endocrinopathies; fertility, growth, bone and metabolic status; subsequent malignant neoplasms (SMNs).

Results
Gonadotoxicity was more common in females (P &lt; .001). Total body irradiation (TBI) conditioning was more toxic than chemotherapy alone. All females receiving TBI or higher cyclophosphamide equivalent doses developed premature ovarian insufficiency. In males, impaired spermatogenesis +/- testicular endocrine dysfunction was associated with increasing testicular radiation exposure. Preservation of gonadal function was associated with younger age at HSCT. Of sexually active females, 22% reported spontaneous pregnancies. Short stature was common, with GH axis disruption in 30% of these. Of patients exposed to thyroid radiation, 51% developed nodules; 30% were malignant. Metabolic disturbances included hypertension and dyslipidemias, with both excess and underweight reported. Fragility fractures occurred in 6% and avascular necrosis in 6%. Thirteen percent developed SMNs, with the risk continuing to rise throughout follow-up.

Conclusion
We confirm gonadal dysfunction, multiple endocrine and metabolic abnormalities, thyroid cancer, and SMNs as common sequelae of HSCT and identify gaps in management—particularly the need for informed fertility counseling and pretreatment fertility preservation, evaluation, and management of bone health—and underline the need for early lifestyle modification, long-term surveillance, and prospective planned studies aimed at reducing complication risk.
The Effect of Computer Monitoring on Employees’ Productivity in Telecommuting Arrangements
Authors: Ko Yea Hee , Baek In Gyun 
Published: March 2024

When employees work from home, organizations have traditionally placed a stronger reliance on output-based controls because of the inability to physically observe its employees. Because of recent advances in technology, however, many organizations now use input-based controls. One such input-based control is computer monitoring, which records the number of hours spent working and leaves out any time in which an employee does not perform work activities. On the one hand, computer monitoring may provide productivity-enhancing benefits by reducing the likelihood of employees experiencing self-control problems, such as procrastination. On the other hand, computer monitoring may motivate reduced effort by decreasing employees’ autonomy, which a prior study finds is an important mediator of the relation between telecommuting and productivity. We take advantage of a field-research setting in which the organization adopts computer monitoring for its telecommuting employees. We find that computer monitoring leads to a 7.1% productivity increase for telecommuting employees. We also find that computer monitoring reduces employees’ procrastination tendencies. In addition, we find that low performers’ productivity increases more following the introduction of computer monitoring. Finally, we find evidence that telecommuters’ departure rates increase significantly following computer monitoring. Our results suggest that technology can play a significant role in expanding organizations’ management control choices when achieving controls in telecommuting arrangements. This paper was accepted by Suraj Srinivasan, accounting. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.00588 .
Trust and electronic word of mouth on purchase intention: Rating as mediator
Authors: Kojongian Keren Sonia Petronela , Ariadi Gede 
Published: March 2024

In an increasingly digital era, trust factors, electronic word of mouth, and ratings have an important role in influencing consumer purchase intention. This study examines the effect of trust and electronic word of mouth, with ratings acting as a mediator, on the purchasing intentions of health products. The research centers on Shopee users residing in Salatiga City during COVID-19. The study sample consisted of 103 inhabitants of Salatiga City who used the Shopee marketplace. The analysis was performed using the partial least-squares structural equation method. The results suggest that trust does not significantly impact purchase intent, but the trust variable has a positive and significant impact on ratings. Moreover, purchase intent was positively and significantly affected by the rating variable. Purchase intention and evaluations are positively and significantly affected by electronic word of mouth elements. It is clear that using ratings as mediators to link trust andpurchase intention has a significant impact. In contrast, the link between electronic word of mouth and purchase intention, where rating serves as a mediator, does not indicate any significant impact.
Effects of injectable contraception with depot medroxyprogesterone acetate or norethisterone enanthate on estradiol levels and menstrual, psychological and behavioral measures relevant to HIV risk: The WHICH randomized trial
Authors: Singata-Madliki Mandisa , Smit Jenni , Beksinska Mags , Balakrishna Yusentha , Avenant Chanel , Beesham Ivana , Seocharan Ishen , Batting Joanne , Hapgood Janet P. , Hofmeyr G. Justus 
Published: March 2024

BackgroundObservational data suggest lower HIV risk with norethisterone enanthate (NET-EN) than with depo-medroxyprogesterone acetate intramuscular (DMPA-IM) injectable contraceptives. If confirmed, a switch between these similar injectable methods would be programmatically feasible and could impact the trajectory of the HIV epidemic. We aimed in this paper to investigate the effects of DMPA-IM and NET-EN on estradiol levels, measures of depression and sexual activity and menstrual effects, relevant to HIV risk; and to ascertain whether these measures are associated with estradiol levels.MethodsThis open-label trial conducted at two sites in South Africa from 5 November 2018 to 30 November 2019, randomized HIV-negative women aged 18–40 to DMPA-IM 150 mg intramuscular 12-weekly (n = 262) or NET-EN 200 mg intramuscular 8-weekly (n = 259). Data were collected on hormonal, behavioral and menstrual effects at baseline and at 25 weeks (25W).ResultsAt 25W, median 17β estradiol levels were substantially lower than at baseline (p<0.001) for both methods: 76.5 pmol/L (interquartile range (IQR) 54.1 to 104.2) in the DMPA-IM group (n = 222), and 69.8 pmol/L (IQR: 55.1 to 89.3) in the NET-EN group (n = 225), with no statistical difference between the two methods (p = 0.450). Compared with DMPA-IM, NET-EN users reported significantly less amenorrhoea, fewer sexual acts, fewer users reporting at least one act of unprotected sex, more condom use with steady partner, more days with urge for sexual intercourse, more days feeling partner does not love her, and more days feeling sad for no reason. We did not find a clear association between estradiol levels and sexual behavior, depression and menstrual effects. Behavioral outcomes suggest less sexual exposure with NET-EN than DMPA-IM. The strength of this evidence is high due to the randomized study design and the consistency of results across the outcomes measured.ConclusionsEstradiol levels were reduced to postmenopausal levels by both methods. Secondary outcomes suggesting less sexual exposure with NET-EN are consistent with reported observational evidence of less HIV risk with NET-EN. A randomized trial powered for HIV acquisition is feasible and needed to answer this important question.Trial registrationPACTR 202009758229976.
Use of tobacco and other illicit drugs among adolescent boys and young men in Kampala, Uganda: A result of low parental attention?
Authors: Mulyowa Alex , Ssekamatte Tonny , Kabwama Steven N. , Ssenkusu John , Wanyenze Rhoda K. , Matovu Joseph K. B. 
Published: March 2024

Introduction
Although the use of illicit drugs is common among young people, limited data exists on the use of illicit drugs among adolescent boys and young men (ABYM). We assessed the use of tobacco, marijuana and khat among ABYM to inform the design of harm-reduction interventions.

Methods
This secondary analysis uses data from a formative study conducted among 2,500 ABYM across the five divisions of Kampala between July and August 2020. Survey questions were adopted from the Global Youth Tobacco Survey and Global School-based Student Health Survey. We computed proportions of ABYM that had ever used any form of tobacco or marijuana or khat in the past year and the proportion that had used any of these products in the past 30 days (i.e. ‘current users’). In a sub-group analysis, we assessed if any patterns existed between ABYM’s use of illicit drugs and selected parental attention attributes.

Results
Of 2,500 ABYM, 47.3% (n = 1,182) were aged 15–19 years. Overall, 16.4% (n = 410) reported past-year use of tobacco products while 11.6% (n = 289) and 10.5% (n = 263) reported past-year use of marijuana and khat, respectively. Current use of any illicit drugs was higher among past-year khat (46%, n = 133) and marijuana users (36.9%, n = 97) than past-year tobacco users (4%, n = 17). Current use of any illicit drugs was higher among out-of-school than in-school ABYM and increased with increasing age and education levels. However, parental attention was lower among out-of-school than in-school ABYM and decreased with increasing age and education levels.

Conclusion
Use of illicit drugs is common among ABYM and increased with age and education levels but parental attention among current illicit drug users decreased with increasing age and education levels. These findings suggest that interventions intended to improve parental attention among illicit drug users may help to reduce the prevalence of illicit drug use among ABYM.
Effectiveness and cost-effectiveness of a collaborative deprescribing intervention of proton-pump-inhibitors on community-dwelling older adults: Protocol for the C-SENIoR, a pragmatic non-randomized controlled trial
Authors: Romano Sónia , Monteiro Luis , Guerreiro José Pedro , Simões João Braga , Teixeira Rodrigues António , Lunet Nuno , Perelman Julian 
Published: March 2024

Introduction
Worldwide, demographic ageing is a major social, economic and health challenge. Despite the increase in life expectancy, elderly often live with multiple chronic conditions, exposing them to multiple medications. Concerns have been raised about the growing issue of inappropriate long-term usage of proton-pump inhibitors (PPI), which have been associated with adverse outcomes and increased healthcare costs. Deprescribing is a recommended intervention to reduce or withdraw medicines that might be causing harm or might no longer be of benefit. This protocol details a trial to assess the effectiveness and cost-effectiveness of a collaborative deprescribing intervention of PPI among community-dwelling elderly, involving community pharmacists and general practitioners.

Methods and analysis
A pragmatic, multicentre, two-arm, non-randomised controlled trial of a structured PPI collaborative deprescribing intervention in the primary care setting with a 6-month follow-up will be conducted. Patients must be 65 years old or older, live in the community and have been using PPI for more than 8 weeks. We hypothesize that the intervention will reduce the PPI usage in the intervention group compared to the control group. The primary outcome is the successful discontinuation or dose decrease of any PPI, defined as a statistically significant absolute 20% reduction in medication use between the intervention and control groups at 3- and 6-month follow-ups. An economic evaluation will be conducted alongside the trial. This study was approved by the Ethics Research Committee of Nova Medical School, NOVA University of Lisbon and by the Ethics Committee from the Local Health Unit Alto Minho, Portugal.

Discussion
This pragmatic trial will provide evidence on the effectiveness and cost-effectiveness of a patient-centred collaborative deprescribing intervention in the community setting in Portugal. It will also inform improvements for the development of future multi-faceted interventions that aim to optimise medication for the community-dwelling elderly.

Clinical trial registration
ISRCTN 49637686.
Experiencing Music Technology, David B. Williams and Peter R. Webster (2022), 4th ed.
Authors: Mattio Candice D. 
Published: March 2024

Review of: Experiencing Music Technology, David B. Williams and Peter R. Webster (2022), 4th ed.
New York: Oxford University Press, 576 pp.,
ISBN 978-0-19063-579-4, p/bk, $99.99
ISBN 978-0-19063-581-7, e-book, $81.52