bluuebunny/crossref_metadata_2025_split huggingface dataset:
Racial Differences in Plasma Microbial Translocation and Plasma Microbiome, Implications in Systemic Lupus Erythematosus Disease Pathogenesis
Authors: Wen Xiaoting , Ogunrinde Elizabeth , Wan Zhuang , Cunningham Melissa , Gilkeson Gary , Jiang Wei 
Published: April 2024

ObjectiveBlack groups have increased prevalence and accelerated pathogenicity of systemic lupus erythematosus (SLE) compared to other ethnic/racial groups. The microbiome and systemic microbial translocation are considered contributing factors to SLE disease pathogenesis. However, racial differences in the plasma microbiome and microbial translocation in lupus remain unknown.MethodsIn the current study, we investigated plasma levels of microbial translocation (lipopolysaccharide [LPS] and zonulin) and the plasma microbiome using microbial 16S RNA sequencing of Black and White patients with SLE and Black and White healthy controls.ResultsPlasma microbial translocation was increased in Black patients versus in White patients and in patients with SLE versus healthy controls regardless of race. Compared to sex, age, and disease status, race had the strongest association with plasma microbiome differences. Black groups (Black controls and Black patients) had lower α‐diversity than White groups (White controls and White patients) and more distinct β‐diversity. Black and White patients demonstrated differences in plasma bacterial presence, including Staphylococcus and Burkholderia. Compared to White patients, Black patients had higher SLE Disease Activity Index (SLEDAI) scores and urinary protein levels as well as a trend for increased anti–double‐stranded DNA (dsDNA) antibody levels consistent with the known increased severity of lupus in Black patients overall. Certain plasma bacteria at the genus level were identified that were associated with the SLEDAI score, urinary protein, and anti‐dsDNA antibody levels.ConclusionThis study reveals racial differences in both quality and quantity of plasma microbial translocation and identified specific plasma microbiome differences associated with SLE disease pathogenesis. Thus, this study may provide new insights into future potential microbiome therapies on SLE pathogenesis.
In‐Situ Polymerization Confined PEGDME‐Based Composite Quasi‐Solid‐State Electrolytes for Lithium Metal Batteries
Authors: Tong Rong‐Ao , Huang Yilei , Feng Chang , Dong Yanhao , Wang Chang‐An 
Published: April 2024

AbstractSolid‐state lithium metal batteries are under development for higher energy density and better safety. A key is to develop new electrolyte systems that are readily processible and capable to improve electrochemical cycling stability. In this study, A quasi‐solid‐state composite electrolyte based on low‐molecular‐weight polyethylene glycol dimethyl ether (PEGDME) in situ confined within polymerized methyl methacrylate (PMMA) backbone is designed and presented. The new design of the polymer matrix, together with Li+‐conducting ceramic fillers and appropriate lithium salts, has satisfactory Li‐ionic conductivity (1.1 × 10−4 S cm−1 at 30 C and 1.0 × 10−3 S cm−1 at 80 °C), good electrochemical stability (>4.7 V vs Li+/Li), and high compatibility with lithium metal anode, enabling room‐temperature operation and stable long‐term cycling of both Li||Li symmetric cells and lithium‐metal full cells (including LiFePO4 or LiCoO2 cathode). This work can extend the design boundaries of composite electrolytes meaningfully, and the idea of in situ polymerization limiting applies to almost all low‐molecular‐weight polymers, high‐molecular‐weight backbones, ceramic fillers, lithium salts, and additives in future development of room‐temperature solid‐state lithium metal batteries.
On‐Skin Paintable Water‐Resistant Biohydrogel for Wearable Bioelectronics
Authors: Luo Jiabei , Sun Chuanyue , Chang Boya , Zhang Bin , Li Kerui , Li Yaogang , Zhang Qinghong , Wang Hongzhi , Hou Chengyi 
Published: April 2024

AbstractTo achieve accurate monitoring of bioelectrical signals, it is essential to use customizable bioelectrodes that can self‐adapt to the skin's surface topography. Ion‐conducting hydrogel has received significant attention in this field due to its softness, adhesion, and skin‐like mechanical properties. However, these bioelectrodes currently suffer from degradation of adhesion, electrical conductivity, and skin‐compliance when exposed to aqueous environments. This significantly limits the application of bioelectrodes. Herein, a customizable biohydrogel that can be applied on skin or fabric by solvent volatilization for liquid ink‐gel film conversion is reported. The biohydrogel's distinct characteristic of transitioning between a liquid and hydrogel phase establishes superb conformal contact and dynamic compliance with the epidermis. This effectively eliminates motion artifacts and results in lower contact impedance and noise in both static and dynamic states when compared to existing bioelectrodes. The biohydrogel is applied to the cotton fabric to create electrocardiogram (ECG) monitoring garments. These garments enable the acquisition of ECG signals with high accuracy in aqueous environment for over 72 h. Besides, the biohydrogel‐based garments outperform the commercial gel electrodes by 83.5% in signal‐to‐noise ratio. Additionally, the cotton/biohydrogel electrode facilitates multi‐channel, high‐fidelity recording of ECG signals, enabling high‐performance capture and classification of ECG waveforms across multiple channels.
Layer‐By‐Layer Chiral Induction of Fluorene‐Based Metal–Organic Framework Films for Circularly Polarized Luminescence Sensing of Enantiomers
Authors: Li Chong , Yang Xue‐Xian , Zheng Ming‐Yi , Gu Zhi‐Gang , Zhang Jian 
Published: April 2024

AbstractDeveloping films of chiral metal–organic frameworks (MOFs) with high circular polarization luminescence (CPL) is facing a great challenge for chiral sensing applications. Herein, a layer‐by‐layer chiral induction method is first reported to prepare enantiopure MOF films for CPL sensing. By layer‐by‐layer induction with the chiral inductor camphorsulfonic acid, fluorene‐based chiral MOF D/L‐ZnHF‐SO2 film (HF‐SO2 = 3,7‐Dibenzothiophenedicarboxylate, 5,5‐dioxide) with preferential growth orientation and homogeneous surface are prepared, which shows strong chiral feature and CPL with higher asymmetry factor of ±0.073. In addition, by mixed ligand approach, the isostructural fluorene ligand 9‐fluororenone‐2,7‐dicarboxylate is chosen to replace part of HF‐SO2 for preparing a series of chiral MOF films with tunable CPL emission. Furthermore, the prepared chiral MOF films with strong CPL performance are further utilized for enantiomers sensing. The CPL changes consisted with enantioselective adsorption results showed that D/L‐ZnHF‐SO2 film has good discrimination against chiral R/S‐phenylethylamine enantiomers, first reporting chiral MOF‐based candidates for the application in CPL sensing of enantiomers. This work provides a facile and effective approach for preparing chiral MOF films materials with high and tunable CPL performance, and also gives a new way to achieve CPL sensing of chiral enantiomers.
Cross‐Scale Drug Delivery of Diatom Microrobots Based on A Magnetic Continuum Robot for Combined Chemical and Photodynamic Therapy of Glioblastoma
Authors: Li Mengyue , Wu Junfeng , Li Na , Zhou Junjian , Cheng Wen , Wu Anhua , Liu Lianqing , Jiao Niandong 
Published: April 2024

AbstractMicro/nanorobots with active movement capabilities provide a new option for the treatment of glioblastoma (GBM). However, the long working distance of intravenous injection and the protection of the blood‐brain barrier can prevent micro/nanorobots from reaching the target location. Photodynamic therapy (PDT) has gradually appeared in GBM treatment research. The limitation of the penetrating strength of the light source will nevertheless hinder the application range of PDT. Herein, a magnetic continuum robot (MCR) to deliver optical fibers and microrobots for combined chemotherapy and PDT of GBM is used. The prepared magnetic diatom microrobots can effectively move in biological fluids and move upstream. Vacuum loading can improve the drug loading efficiency. The photosensitizer in the frustule cavity can be explosively released in a short time through ultrasound. The chemotherapeutic drugs have long‐term and pH‐sensitivity release characteristics. In vitro cell experiments showed that the combined administration of TMZ‐loaded microrobots and photosensitizer‐loaded microrobots has a synergistic effect. The in vitro model demonstrated that an MCR can deliver an optical fiber and drug‐loaded microrobots. This enables cross‐scale delivery of microrobots and deep PDT. This delivery method may expand the drug selectivity for GBM treatment and provide a new possibility for intracranial PDT.
A Wood‐Derived Periosteum for Spatiotemporal Drug Release: Boosting Bone Repair through Anisotropic Structure and Multiple Functions
Authors: Sun Tianyi , Chen Chunhua , Liu Kun , Li Lin , Zhang Ruixi , Wen Wei , Ding Shan , Liu Mingxian , Zhou Changren , Luo Binghong 
Published: April 2024

AbstractExisting artificial periostea face many challenges, including difficult‐to‐replicate anisotropy in mechanics and structure, poor tissue adhesion, and neglected synergistic angiogenesis and osteogenesis. Here, inspired by natural wood (NW), a wood‐derived elastic artificial periosteum is developed to mimic the structure and functions of natural periosteum, which combines an elastic wood (EW) skeleton, a polydopamine (PDA) binder layer, and layer‐by‐layer (LBL) biofunctional layers. Specifically, EW derived from NW is utilized as the anisotropic skeleton of artificial periosteum to guide cell directional behaviors, moreover, it also shows a similar elastic modulus and flexibility to natural periosteum. To further enhance its synergistic angiogenesis and osteogenesis, surface LBL biofunctional layers are designed to serve as spatiotemporal release platforms to achieve sequential and long‐term release of pamidronate disodium (PDS) and deferoxamine (DFO), which are pre‐encapsulated in chitosan (CS) and hyaluronic acid (HA) solutions, respectively. Furthermore, the combined effect of PDA coating and LBL biofunctional layers enables the periosteum to tightly adhere to damaged bone tissue. More importantly, this novel artificial periosteum can boost angiogenesis and bone formation in vitro and in vivo. This study opens up a new path for biomimetic design of artificial periosteum, and provides a feasible clinical strategy for bone repair.
Evolution of Musculoskeletal Electronics
Authors: Li Jia , Zhang Fengjiao , Lyu Houchen , Yin Pengbin , Shi Lei , Li Zhiyi , Zhang Licheng , Di Chong‐an , Tang Peifu 
Published: April 2024

AbstractThe musculoskeletal system, constituting the largest human physiological system, plays a critical role in providing structural support to the body, facilitating intricate movements, and safeguarding internal organs. By virtue of advancements in revolutionized materials and devices, particularly in the realms of motion capture, health monitoring, and postoperative rehabilitation, “musculoskeletal electronics” has actually emerged as an infancy area, but has not yet been explicitly proposed. In this review, the concept of musculoskeletal electronics is elucidated, and the evolution history, representative progress, and key strategies of the involved materials and state‐of‐the‐art devices are summarized. Therefore, the fundamentals of musculoskeletal electronics and key functionality categories are introduced. Subsequently, recent advances in musculoskeletal electronics are presented from the perspectives of “in vitro” to “in vivo” signal detection, interactive modulation, and therapeutic interventions for healing and recovery. Additionally, nine strategy avenues for the development of advanced musculoskeletal electronic materials and devices are proposed. Finally, concise summaries and perspectives are proposed to highlight the directions that deserve focused attention in this booming field.
A Multimodal Self‐Propelling Tensegrity Structure
Authors: Liu Changyue , Li Kai , Yu Xinzi , Yang Jiping , Wang Zhijian 
Published: April 2024

AbstractTensegrity structure is composed of tensile cables and compressive rods, offering high stiffness‐to‐mass ratio, deploy ability, and excellent energy damping capability. The active and dynamic tensegrity designs demonstrate great potential for soft robots. In previous designs, the movement has relied on carefully controlled input power or manually controlled light irradiation, limiting their potential applications. Here, a hybrid tensegrity structure (HTS) is constructed by integrating thermally responsive cables, nonresponsive cables, and stiff rods. The HTS can self‐propel continuously on a hot surface due to its unique geometry. The HTS allows for the easy achievement of multimodal self‐propelled locomotive modes, which has been challenging for previously demonstrated self‐propelling structures. Additionally, using Velcro tapes to adhere the rods and cables together, a modulable and reassemblable HTS is created. The HTS introduced in this study presents a new strategy and offers a large design space for constructing self‐propelling and modulable robots.
Efficient Electrochemical Co‐Reduction of Carbon Dioxide and Nitrate to Urea with High Faradaic Efficiency on Cobalt‐Based Dual‐Sites
Authors: Fan Xiaoya , Liu Chaozhen , He Xun , Li Zixiao , Yue Luchao , Zhao Wenxi , Li Jun , Wang Yan , Li Tingshuai , Luo Yongsong , Zheng Dongdong , Sun Shengjun , Liu Qian , Li Luming , Chu Wei , Gong Feng , Tang Bo , Yao Yongchao , Sun Xuping 
Published: April 2024

AbstractRenewable electricity‐powered nitrate/carbon dioxide co‐reduction reaction toward urea production paves an attractive alternative to industrial urea processes and offers a clean on‐site approach to closing the global nitrogen cycle. However, its large‐scale implantation is severely impeded by challenging C–N coupling and requires electrocatalysts with high activity/selectivity. Here, cobalt‐nanoparticles anchored on carbon nanosheet (Co NPs@C) are proposed as a catalyst electrode to boost yield and Faradaic efficiency (FE) toward urea electrosynthesis with enhanced C–N coupling. Such Co NPs@C renders superb urea‐producing activity with a high FE reaching 54.3% and a urea yield of 2217.5 µg h−1 mgcat.−1, much superior to the Co NPs and C nanosheet counterparts, and meanwhile shows strong stability. The Co NPs@C affords rich catalytically active sites, fast reactant diffusion, and sufficient catalytic surfaces‐electrolyte contacts with favored charge and ion transfer efficiencies. The theoretical calculations reveal that the high‐rate formation of *CO and *NH2 intermediates is crucial for facilitating urea synthesis.
Role of Solvent in the Oriented Growth of Conductive Ni‐CAT‐1 Metal‐Organic Framework at Solid–Liquid Interfaces
Authors: Shin Sun Hae Ra , Tao Jinhui , Canfield Nathan L. , Bowden Mark E. , Liu Lili , Sivakumar Bhuvaneswari M. , Liu Jun , De Yoreo James J. , Thallapally Praveen K. , Sushko Maria L. 
Published: April 2024

AbstractA controlled growth of two‐dimensional (2D) π‐conjugated metal‐organic frameworks (MOFs) on solid substrates can open exciting opportunities for the application of 2D MOFs as optoelectronic devices. Some factors like solvent composition and type of substrates are known to influence the properties of solution‐processed 2D MOF crystals; however, a mechanistic understanding of how interactions between solvent, substrate, and precursors affect heterogeneous nucleation has been limited. Here, it is reported that the structure of Ni‐catecholate (Ni‐CAT‐1) MOFs at a solid–liquid interface is controlled by solvent–substrate and solvent–MOF precursor interactions. Specifically, the structure of the MOF film can be controlled by varying the affinity of the solvent to the substrate. As a fraction of N,N‐dimethylformamide (DMF) in a binary solvent mixture of water and DMF increases, the arrangement of Ni‐CAT‐1 crystals varies from vertically aligned nanorods to the graphite substrate to less ordered nanorods with the lower initial nucleation number density of Ni‐CAT‐1 crystals on the surface.
A multivariate multilevel approach to unravel the associations between individual and school factors on children's motor performance in the REACT project
Authors: Maia José , Santos Carla , Pereira Sara , Hedeker Donald , Barreira Tiago V. , Garganta Rui , Farias Cláudio , Garbeloto Fernando , Tani Go , Cruz Hugo , Chaput Jean‐Philippe , Stodden David F. , Katzmarzyk Peter T. 
Published: April 2024

AbstractObjectiveThe aim was to (1) estimate the relationship between physical fitness (PF) and object control fundamental movement skills (FMS), (2) identify child characteristics that relate with PF and FMS, and (3) examine associations between the school environment, PF, and FMS.MethodsThe sample included 1014 Portuguese children aged 6–10 years from the REACT project. PF was assessed via running speed, shuttle run, standing long jump, handgrip, and the PACER test. Object control FMS were assessed with stationary dribble, kick, catch, overhand throw, and underhand roll. Test performances were transformed into z‐scores, and their sum was expressed as overall PF and FMS. Child‐level variables included body mass index (BMI) z‐scores, accelerometer‐measured sedentary time and moderate‐to‐vigorous physical activity, and socioeconomic status (SES). School size, physical education classes, practice areas, and equipment were also assessed.ResultsApproximately, 90% of the variance in object control PF and FMS was at the child level, and 10% at the school level. The correlation between PF and object control FMS was .62, which declined to .43 with the inclusion of covariates. Older, more active, and higher SES children had higher object control PF and FMS, and boys outperformed girls. BMI was negatively associated with PF but not with object control FMS. Sedentary time and number of physical education classes were not significant predictors. Most school predictors did not jointly associate with PF and object control FMS.ConclusionPF and object control FMS z‐scores were moderately related. Not all child characteristics were associated with both PF and object control FMS, and their effect sizes were different. School characteristics only explained 10% of the total variation in PF and object control FMS.
Trends in workplace homicides in the U.S., 1994–2021: An end to years of decline
Authors: Hendricks Scott A. , Hendricks Kitty J. , Tiesman Hope M. , Gomes Harold L. , Collins James W. , Hartley Dan 
Published: April 2024

AbstractWorkplace and non‐workplace homicides in the United States (U.S.) have declined for over 30 years until recently. This study was conducted to address the change in trends for both workplace and non‐workplace homicides and to evaluate the homogeneity of the change in workplace homicides by specified categories. Joinpoint and autoregressive models were used to assess trends of U.S. workplace and non‐workplace homicides utilizing surveillance data collected by the Bureau of Labor Statistics and the Federal Bureau of Investigation from 1994 through 2021. Both workplace and non‐workplace homicides decreased significantly from 1994 through 2014. Workplace homicides showed no significant trend from 2014 through 2021 (p = 0.79), while non‐workplace homicides showed a significant average annual increase of 4.1% from 2014 through 2020 (p = 0.0013). The large decreases in the trend of workplace homicides occurring during a criminal act, such as robbery, leveled off and started to increase by the end of the study period (p < 0.0001). Declines in workplace homicides due to shootings also leveled off and started to increase by the end of the study period (p < 0.0001). U.S. workplace and non‐workplace homicide rates declined from the 1990s until around 2014. Trends in workplace homicides varied by the types of the homicide committed and by the type of employee that was the victim. Criminal‐intent‐related events, such as robbery, appear to be the largest contributor to changes in workplace homicides. Researchers and industry leaders could develop and evaluate interventions that further address criminal‐intent‐related workplace homicides.
Two sisters with RSPRY1‐related spondyloepimetaphyseal dysplasia
Authors: Singh Swati , Shah Hitesh , Dalal Ashwin , Shukla Anju , Bhavani Gandham SriLakshmi , Girisha Katta M. 
Published: April 2024

AbstractBiallelic variants in RSPRY1 have been found to result in spondyloepimetaphyseal dysplasia. Two siblings presenting with short stature, facial dysmorphism, progressive vertebral defects, small epiphysis, cupping and fraying of metaphyses, brachydactyly, and short metatarsals harbored a homozygous missense variant c.1652G>A;p.(Cys551Tyr) in the RSPRY1 gene. The phenotype in our patients resembles spondyloepimetaphyseal dysplasia, Faden‐Alkuraya type. Thus, our study provides further evidence to support the association of RSPRY1 variants with spondyloepimetaphyseal dysplasia. We observed joint dislocation as a novel clinical feature of this condition.
SYNGAP1‐related developmental and epileptic encephalopathy: Genotypic and phenotypic characteristics and longitudinal insights
Authors: Kim Hye Jin , Kim Minhye , Jang Seoyun , Cho Jae So , Kim Soo Yeon , Cho Anna , Kim Hunmin , Lim Byung Chan , Chae Jong‐Hee , Choi Jieun , Kim Ki Joong , Kim WooJoong 
Published: April 2024

AbstractThe clinical and genetic characteristics of SYNGAP1 mutations in Korean pediatric patients are not well understood. We retrospectively analyzed 13 individuals with SYNGAP1 mutations from a longitudinal aspect. Clinical data, genetic profiles, and electroencephalography (EEG) patterns were examined. Genotypic analyses included gene panels and whole‐exome sequencing. All patients exhibited global developmental delay from early infancy, with motor development eventually reaching independent ambulation by 3 years of age. Language developmental delay varied significantly from nonverbal to simple sentences, which plateaued in all patients. Patients with the best language outcomes typically managed 2–3‐word sentences, corresponding to a developmental age of 2–3 years. Epilepsy developed in 77% of patients, with onset consistently following developmental delays at a median age of 31 months. Longitudinal EEG data revealed a shift from occipital to frontal epileptiform discharges with age, suggesting a correlation with synaptic maturation. These findings suggest that the critical developmental plateau occurs between the ages of 2 and 5 years and is potentially influenced by epilepsy. By analyzing longitudinal data, our study contributes to a deeper understanding of SYNGAP1‐related DEE, provides potential EEG biomarkers, and underlines the importance of early diagnosis and intervention to address this complex disorder.
The society for craniofacial genetics and developmental biology 46th annual meeting
Authors: Brugmann Samantha A. , Clouthier David E. , Fantauzzo Katherine A. , Harris Matthew P. , Jeong Juhee , Saint‐Jeannet Jean‐Pierre , Stottmann Rolf W. , Merrill Amy E. 
Published: April 2024

AbstractThe Society for Craniofacial Genetics and Developmental Biology (SCGDB) held its 46th Annual Meeting at Cincinnati Children's Hospital Medical Center in Cincinnati, Ohio on October 10th–12th, 2023. On the first day of the meeting, Drs. Sally Moody and Justin Cotney were each honored with the SCGDB Distinguished Scientist Awards for their exceptional contributions to the field of craniofacial biology. The following two days of the meeting featured five sessions that highlighted new discoveries in signaling and genomic mechanisms regulating craniofacial development, human genetics, translational and regenerative approaches, and clinical management of craniofacial differences. Interactive workshops on spatial transcriptomics and scientific communication, as well as a poster session facilitated meaningful interactions among the 122 attendees representing diverse career stages and research backgrounds in developmental biology and genetics, strengthened the SCGDB community.