bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current status and future perspectives on stem cell transplantation for spinal cord injury
Authors: Agosti Edoardo , Zeppieri Marco , Pagnoni Andrea , Fontanella Marco Maria , Fiorindi Alessandro , Ius Tamara , Panciani Pier Paolo 
Published: March 2024

BACKGROUND
Previous assessments of stem cell therapy for spinal cord injuries (SCI) have encountered challenges and constraints. Current research primarily emphasizes safety in early-phase clinical trials, while systematic reviews prioritize effectiveness, often overlooking safety and translational feasibility. This situation prompts inquiries regarding the readiness for clinical adoption.
AIM
To offer an up-to-date systematic literature review of clinical trial results concerning stem cell therapy for SCI.
METHODS
A systematic search was conducted across major medical databases [PubMed, Embase, Reference Citation Analysis (RCA), and Cochrane Library] up to October 14, 2023. The search strategy utilized relevant Medical Subject Heading (MeSH) terms and keywords related to "spinal cord", "injury", "clinical trials", "stem cells", "functional outcomes", and "adverse events". Studies included in this review consisted of randomized controlled trials and non-randomized controlled trials reporting on the use of stem cell therapies for the treatment of SCI.
RESULTS
In a comprehensive review of 66 studies on stem cell therapies for SCI, 496 papers were initially identified, with 237 chosen for full-text analysis. Among them, 236 were deemed eligible after excluding 170 for various reasons. These studies encompassed 1086 patients with varying SCI levels, with cervical injuries being the most common (42.2%). Bone marrow stem cells were the predominant stem cell type used (71.1%), with various administration methods. Follow-up durations averaged around 84.4 months. The 32.7% of patients showed functional improvement from American spinal injury association Impairment Scale (AIS) A to B, 40.8% from AIS A to C, 5.3% from AIS A to D, and 2.1% from AIS B to C. Sensory improvements were observed in 30.9% of patients. A relatively small number of adverse events were recorded, including fever (15.1%), headaches (4.3%), muscle tension (3.1%), and dizziness (2.6%), highlighting the potential for SCI recovery with stem cell therapy.
CONCLUSION
In the realm of SCI treatment, stem cell-based therapies show promise, but clinical trials reveal potential adverse events and limitations, underscoring the need for meticulous optimization of transplantation conditions and parameters, caution against swift clinical implementation, a deeper understanding of SCI pathophysiology, and addressing ethical, tumorigenicity, immunogenicity, and immunotoxicity concerns before gradual and careful adoption in clinical practice.
Guaranteed information as a component of supporting the work of professional communities of teachers in the Krasnodar Region
Authors: Бегзадян Н.А. 
Published: March 2024

В статье рассмотрены различные аспекты деятельности профессиональных сообществ педагогических работников, в частности их основные функции и решаемые задачи. Описана структура управляемого профессионально-педагогического сообщества. Представлен опыт информационно-методического сопровождения работы профессиональных сообществ педагогических работников Краснодарского края. Построена модель гарантированного информирования участников сообществ, представлен регламент этой деятельности.
The article discusses various aspects of the activities of professional communities of pedagogical workers, in particular, their main functions and tasks to be solved. The structure of a managed professional-pedagogical community is described. The experience of information and methodological support of the work of professional communities of pedagogical workers of the Krasnodar Territory is presented. A model of guaranteed informing of community members was built and the regulations for this activity were presented.
Organization of the work of the resource center for teaching staff of educational centers “Point of Growth”
Authors: Исаенко В.А. 
Published: March 2024

Представлено авторское понимание ресурсного центра для педагогических работников центров образования «Точка роста». Определены его место в муниципальной системе образования и основные задачи: 1) координация деятельности центров образования «Точка роста» в муниципалитете; 2) методическая поддержка педагогов и формирование единого информационно-образовательного пространства; 3) создание условий для личностно мотивированного участия детей в развитии познавательной и творческой активности; 4) проведение целенаправленной просветительской и информационно-разъяснительной работы. Сформулированы основные принципы деятельности: 1) принцип коллективного доступа к ресурсам центров образования «Точка роста», обеспечивающий взаимодействие по их использованию; 2) принцип партнёрства, предполагающий разнообразные формы сотрудничества; 3) принцип непрерывности образования, обеспечивающий обучающимся переход от одной образовательной программы к другой на основе взаимосвязи сети центров образования «Точка роста». Представлена модель ресурсного центра для педагогических работников центров образования «Точка роста», охарактеризованы его субъекты и их роль, предложена циклограмма работы. Разработаны критерии оценки эффективности деятельности образовательных центров «Точка роста».
The author's understanding of the resource center for teaching staff of educational centers “Point of Growth” is presented. Its place in the municipal education system and the main tasks are determined: 1) coordination of the activities of the education centers “Point of Growth” in the municipality; 2) methodological support for teachers and the formation of a single information and educational space; 3) creation of conditions for personally motivated participation of children in the development of cognitive and creative activity; 4) carrying out purposeful educational and information-explanatory work. The main principles of activity are formulated: 1) the principle of collective access to the resources of the education centers “Point of Growth”, which ensures interaction in their use; 2) the principle of partnership, which implies various forms of cooperation; 3) the principle of continuity of education, which provides students with the transition from one educational program to another based on the interconnection of the network of education centers “Point of Growth”. The model of the resource center for pedagogical workers of the educational centers “Point of Growth” is presented, its subjects and their role are characterized, the cyclogram of work is offered. Criteria for evaluating the effectiveness of the educational centers “Point of Growth” have been developed.
Review of Accredited Operator Schemes: An Australian Study
Authors: Widdowson David , Blegen Bryce , Kashubsky Mikhail , Grainger Andrew 
Published: March 2024

Governments throughout the world have for many years been developing and implementing initiatives that are designed to secure international supply chains from terrorist and other threats while facilitating legitimate trade. A number of these initiatives involve the accreditation of members of the international trading community that meet security and other regulatory requirements. This article summarises a research study that was commissioned by the Australian international trade and transport industry. The research study reviews the various types of ‘Accredited Operator’ (AO) schemes that are currently in use or being implemented and identifies options for their application in Australia. In doing so, it has sought the views of industry and has focused on ways to maximise the relevance of such schemes, minimise compliance costs and ensure against the possible erosion of Australian industry’s competitive position in the global marketplace. The study identifies a potential disadvantage to Australian exporters of not having access to a scheme that meets the requirements of the SAFE Framework of Standards to Secure and Facilitate Global Trade (the SAFE Framework). It proposes the introduction of such a scheme with supply chain security as its principal focus, and an import scheme having trade compliance as its principal focus. It argues that participants in the export scheme would also need to demonstrate appropriate levels of trade compliance, and importers should similarly be required to meet minimum security requirements.
Estrategia metodológica para el fortalecimiento de la lectoescritura en estudiantes de cuarto grado
Authors: Molina-Rivas María Yanet , Samada-Grasst Yanet 
Published: March 2024

Leer y escribir, son dos actos que parecen tan naturales para el ser humano, pero que requieren todo un acto de conciencia de su parte para llegar a ser autónomo y competente en el desarrollo de la lectoescritura. Es por ello se proyectó como objetivo general de la investigación el diseñar una estrategia metodológica para el fortalecimiento de la lectoescritura en los estudiantes de cuarto grado de la escuela Eloy Alfaro, parroquia San Pablo, provincia de Manabí en el Ecuador. Para ellos se realizó una investigación bajo un enfoque mixto cuali-cuantitativo, de tipo descriptiva, además se trabajó con los métodos teóricos como el inductivo – deductivo, análisis -síntesis, y análisis documental, dentro de los empíricos se utilizaron la observación y encuesta. Entre los principales hallazgos en el desarrollo de la lectoescritura, se identificó que los estudiantes cambian, omiten o confunden las letras y los fonemas, alterando el orden o confundiendo los sonidos. Se concluye que el rol que asume el docente en el desarrollo de la lectoescritura involucra diversas funciones e influye en su didáctica, las cuales se relacionan con la facilitación del aprendizaje, el uso de recursos, y la implementación de estrategias metodológicas como método de enseñanza.
Pendidikan Kesehatan Menggunakan Video Animasi Tentang Bahaya Merokok Pada Remaja di SMAN 01 Muaro Jambi
Authors: Triana Winda , Asmuni Asmuni , Almuhaimin Almuhaimin , Upix Desif 
Published: March 2024

Rokok merupakan salah satu faktor risiko utama dari beberapa penyakit kronis yang dapat mengakibatkan kematian. Hal ini menunjukkan bahwa rokok merupakan masalah besar bagi kesehatan masyarakat. Selain dari segi kesehatan, rokok juga mempengaruhi kepribadian perokok itu sendiri. Biasanya remaja usia SMA sudah mengenal rokok. Pengabdian ini bertujuan untuk melaksanakan pendidikan kesehatan menggunakan video animasi tentang bahaya merokok pada remaja. Pengabdian kepada masyarakat dengan sasaran siswa sekolah menengah atas tentang edukasi bahaya merokok pada remaja berbasis video animasi dapat meningkatkan pengetahuan mahasiswa. Penyuluhan ini dilaksanakan di SMAN 01 Muaro Jambi oleh tim pengabdi dari Poltekkes Kemenkes Jambi. Selama melakukan penyuluhan siswa sangat antusias dalam mendengarkan pemateri, untuk itu diharapkan kegiatan ini digalakkan khususnya di dunia Pendidikan.
PENERAPAN MEDIA LOOSE PART DALAM KEMAMPUAN MOTORIK HALUS PADA ANAK USIA DINI
Authors: Rozak Purnama 
Published: March 2024

Mengenai pembelajaran media loose part yang perlu dikembangkan untuk menjadi suatu media bahan ajar yang dapat digunakan oleh anak usia dini. Media loose part ini dapat mengembangkan berbagai aspek, terutama dalam aspek motorik halu Dengan adanya media pembelajaran berbasis loose part ini dapat memudahkan anak dalam pencapaian perkembangan motorik halusnya. Media loose part merupakan salah satu media yang dapat disusun, dirangkai, digabungkan, dipindahkan dan yang lainnya sesuai dengan keinginan dan kebutuhan anak. Penelitian ini bertujuan untuk mengetahui pembelajaran media loose part untuk meningkatkan kemampuan motorik halus anak. Metode penelitian yang bisa memfasilitasi untuk melakukan analisis ini adalah metode deskriptif dengan pendekatan kualitatif. Teknik pengumpulan data yang digunakan adalah dengan menggunakan observasi dan wawancara. Hasil penelitian ini menunjukkan bahwa, penggunaan media loose part dalam pembelajaran di kelas sudah optimal untuk meningkatkan kemampuan motorik halus anak usia dini, karena media pembelajaran loose part ini merupakan media yang menyenangkan sehingga anak tidak mudah bosan serta dapat menciptakan sebuah karya hasil dirinya. Kesimpulannya, dengan adanya pembelajaran berbasis media loose part ini akan meningkatkan kreativitas serta motorik halus anak dalam aktivitas pembelajaran di kelas. Media loose part juga karena bahan-bahannya mudah ditemukan di lingkungan sekitar anak, maka anak akan belajar untuk menghargai, mendaur ulang bahan-bahan yang ada di sekelilingnnya.
IMPLEMENTASI METODE MURAJA’AH DALAM MENGHAFAL AL-QUR’AN PONPES DARUL ASYFIYA PEMALANG
Authors: Nursidik  
Published: March 2024

Pendidikan memiliki peranan yang sangat penting dan tidak bisa lepas dari kehidupan manusia. Bagi bangsa, pendidikan merupakan kebutuhan yang dapat mencetak sumber daya manusia yang berkualitas baik dari segi spiritual, intelegensi, dan kemampuan sebagai generasi penerus Bangsa. Al-Qur’an merupakan sumber dari segala sumber pesan-pesan ketuhanan, yang pada prinsipnya ia senantiasa mengajak manusia agar dapat senantiasa mengembangkan eksistensi dan potensi yang terpendam di dalam dirinya. Salah satu media yang dijadikan Allah SWT dalam menjaga keutuhan al-Qur’an adalah munculnya beberapa kelompok penghafal al-Qur’an di berbagai negara dengan berbagai macam usia. Dalam sejarah Islam klasik, para penghafal al-Qur’an selalu muncul dalam setiap generasinya, mulai generasi sahabat Rasulullah hingga saat ini. Dengan kondisi santri yang hampir seluruhnya adalah pelajar, tentunya perlu perhatian khusus dalam menjaga kelancaran hafalan al-Qur’an. Karena berdasarkan fakta yang terjadi di lapangan. Setelah dilakukan penelitian di Rumah Tahfizh Ilmina, maka ada beberapa hasil yang menunjukan sebuah perubahan dalam meningkatkan kelancaran atau kualitas hafalan al-Qur’an. Menurut salah seorang santri putri berpendapat bahwa metode muraja’ahnya dilakukan dengan membaca berulang-ulang atau dilakukan ketika shalat. Sementara pelaksanaan muraja’ah dalam salat malam (qiyamullail), para santri mengamalkannya secara berjamaah dengan imam bergantian sesuai dengan jadwal yang sudah ditentukan oleh dewan asatidz. Adapun surah yang dibacakan ketika menjadi imam salat adalah surah-surah yang sudah dihafalkan sesuai dengan pencapaian hafalan masing-masing santri 1 rokaat 1 halaman, sementara salat yang dilaksanakan minimal 4 rakaat
Solusi Pernikahan Anak Kondisi Hamil Sebab Zina Menurut Imam Madzhab (Telaah Psikologis dan Sosiologis Teologis)
Authors: Amirul Bahri  
Published: March 2024

Pernikahan merupakan ikatan suci punya tujuan mulia seperti memperoleh ketenangan hidup yang penuh cinta dan kasih sayang sekaligus memenuhi kebutuhan biologis untuk meneruskan dan memelihara keturunan, menjaga kehormatan dan tujuan ibadah. Realita di masyarakat banyak pernikahan terjadi namun beriringan dengan kejadian perzinaan yang berakibat hamil di luar nikah. Penelitian ini bertujuan untuk menjelaskan pernikahan dan perzinaan dalam aturan Islam. kemudian menerangkan pendapat para Imam madzhab berkenaan dengan permasalahan perzinaan. Serta mengungkap makna pernikahan akibat perzinaan dalam pandangan psikologis dan sosiologis teologis yang terjadi di masyarakat. Penelitian ini dilakukan dengan metode penelitian kepustakaan perihal pemikiran fuqahā’ (jurists) dan kontribusi pemikirannya dengan analisis literal readings serta interpretive and reflexive readings. Hasil penelitian menunjukkan bahwa di dalam agama Islam terdapat sunnah Nabi Saw untuk melaksanakan pernikahan dan menjauhi dari perbuatan zina. Dalam pandangan para Imam madzhab pernikahan karena didahului oleh perzinaan bisa dilakukan, namun terdapat perbedaan perihal waktu dan kapan pernikahan tersebut bisa dilakukan. Perbedaan tersebut disebabkan karena pandangan psikologis dan sosiologis theologis yang terjadi dalam memahami kandungan dari aturan pernikahan yang terjadi karena adanya pernikahan demi kemaslatan masyarakat.
The Concept, Types, and Penalties of Tax Violations: A Study of Afghan Laws Perspective
Authors: Hashimi Sayed Banaras , Aminzai  Mairajuddin 
Published: March 2024

Aim: The main purpose of this study was to clarify the concept, types, and penalties of tax violations according to the laws of Afghanistan, and propose necessary solutions to prevent tax violations in Afghanistan.
Methods: Descriptive and explanatory methods were used in the research of the relevant content. The topic of the research was guided by the Afghanistan Income Tax Law, the Law on Taxation Affairs Administration, the guidelines and manuals of the Ministry of Finance, and the Penal Code of Afghanistan.
Results: The findings of the research show that according to the laws of Afghanistan, some actions are considered tax violations. These are late payment of taxes, the imposition of withholding taxes, failure to submit financial statements on time, failure to protect financial documents, submitting an incorrect identification number, providing false information to employees of financial institutions and obstructing the activities of taxation employees.
Conclusion: The financial laws of Afghanistan have provided some penalties to prevent tax violations, and these punishments play an important role in preventing tax contraventions. However, tax violations still occur due to the lack of professional capabilities of tax agency employees and the weakness of the financial system.
Recommendations: The Afghan government should make some amendments to the income tax law and the law on taxation affairs administration, taking into account the economic conditions of the society and the state of taxpayers. The Ministry of Finance of Afghanistan and Afghanistan Revenue Department (ARD) should design and implement the training courses and workshops about taxation, accounting and interpersonal skill to improve the professional skills and capacity of the employees of the tax agencies, also to undertake necessary measures for the motivation and awareness of taxpayers.
Total Knee Arthroplasty in the Valgus Knee – A Surgical Challenge (Part 1)
Authors: Yordanov Nikolay , Andreev Andrey , Katzarova Maria , Tserovski Stefan , Dimitrov Nikolay 
Published: March 2024

The valgus knee presents a unique set of problems that must be addressed during total knee arthroplasty. Both bone and soft-tissue deformities complicate restoration of proper alignment, positioning of components, and attainment of joint stability. The variables that may need to be addressed include lateral femoral condyle or tibial plateau deficiencies secondary to developmental abnormalities, and/or wear; primary or acquired contracture of the lateral capsular and ligamentous structures; and, occasionally, laxity of the medial collateral ligament. Understanding the specific pathologic anatomy associated with the valgus knee is a prerequisite to selecting the proper surgical method to optimize component position and restore soft-tissue balance. The aim of this article is to review the anatomical variations underlying a valgus knee, to assess the best pre-operative planning and to evaluate how to choose the grade of constraint of the implant. We will also review the main approaches and surgical techniques both for bone cuts and soft tissue management
Primary fibrosarcoma of the distal femur. Report of a rare case
Authors: Kovachev Vihar , Stokov Luben , Kovachev Mancho , Simeonov Emil , Georgiev Georgi 
Published: March 2024

Fibrosarcoma of bone is a relatively rare malignant neoplasia, representing less than 5% of all bone tumors. It is distinguished from other bone sarcomas by the presence of spindle-shaped tumor cells located among intertwining bundles of collagen fibers, without any other type of histological differentiation, such as the formation of cartilage or bone.
In the present report, we present a rare case of primary fibrosarcoma in the distal femur in a 45-year-old patient with complaints of mild pain and swelling in the right knee joint for approximately 6 months. After imaging evaluation, a biopsy was performed; in the second stage, a subsequent resection of 16 cm of the distal femur and its replacement with a tumor endoprosthesis was performed. Three months postoperatively, no local recurrence or metastasis of the tumor was observed.
Orthostatic test as an indicator of the state of the cardiovascular system and autonomic regulation of vascular tone
Authors: Borysenko I.V. , Kozina Zh.L. , Martynenko V.G. , Bazhanova M.V. , Bilyk O.O. , Kalmykova V.I. 
Published: March 2024

Purpose: to identify the influence of body length and various sports on the indicators of vascular regulation of students.
Material and methods. The study involved 42 students who play sports at the amateur level, 18 of them are track and field’s sportsmen (short and medium distance running), 12 are football players, 12 are wrestlers. The number of students with a body length of more than 190 cm was 12 people. The number of students whose body length was 150-175 cm was 30 people. There were no students with a body length of 176-189 cm in the study. Following research methods were used in the work: method of analysis of literature sources; method of determining body length; orthostatic test method; method of determining stroke volume and minute blood volume; methods of statistical data processing (comparison of averages by the Student's method, multivariate analysis of variance).
Results. The results of a more significant impact of judo and football in comparison with running short and medium distances on the indicators of vascular regulation: the best indicators - in judo, the next place - in football, then – in track and field sportsmen. It was found that students with a body length of more than 190 cm have difficulty with vegetative-vascular regulation.
Conclusions. To improve the adaptive capacity of vascular regulation to change the position of the body from horizontal to vertical, it is effective to use any exercise, but the most effective exercises that activate aerobic and anaerobic glycolytic energy systems. In addition, exercises that require frequent transitions from lying (sitting) to standing positions, as well as changes in the direction of movement are useful.
EL PROGRESO MORAL DEL ESPACIO VIRTUAL: DEL OTRO SIGNIFICANTE AL OTRO GENERALIZADO
Authors: Alarcón González Jose Felipe 
Published: March 2024

El uso del espacio virtual invita a una reflexión ética sobre su impacto moral. Sociólogos, psicólogos y filósofos son incapaces acordar sus implicaciones éticas. El presente artículo examina el espacio virtual a través de la teoría de La Construcción Social de la Realidad de Peter L. Berger y Thomas Luckmann, que sostiene que el otro significante conforma el carácter del individuo. Se argumenta que el ciberespacio produce un progreso moral. Por un lado, la multiplicidad de otros significantes representa un obstáculo en la socialización del individuo. Por otro y más importante, los otros significantes constituyen nuevas verdades que favorecen un nuevo orden moral. Este resultado se explica mediante el concepto de otro generalizado originario del filósofo George H. Mead. En conclusión, se propone que el espacio virtual conforma el carácter moral del individuo de forma positiva.
El límite es el cielo. El análisis de Eugen Fink de la idea de mundo en la Crítica de la razón pura y sus implicaciones cosmológicas
Authors: Garrido Maturano Ángel Enrique 
Published: March 2024

ResumenEl artículo reconstruye el análisis de Eugen Fink de la idea de mundo en la Crítica de la razón pura. La reconstrucción presenta dos ejes exegéticos y un tercero hermenéutico. El primero elucida por qué las antinomias de la dialéctica trascendental establecen por vía negativa la diferencia cosmológica. El segundo determina en qué medida la concepción del mundo como idea constituye el límite de la comprensión kantiana del mundo. El último interpreta el mundo desde la noción de acontecimiento-originante y muestra nacimiento y muerte como los modos fundamentales en que el acontecer del mundo se inscribe en el sujeto.