bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peningkatan Kemampuan Pemecahan Masalah Matematis Melalui Model Pembelajaran Discovery Learning dan Hubungannya dengan Self Confidence
Authors: Badriyah Dewi , Sutirna Sutirna , Sopiany Hanifah Nurus 
Published: March 2024

Penelitian ini bertujuan untuk melihat peningkatan kemampuan pemecahan masalah matematis melalui model pembelajaran discovery learning dan hubungannya dengan self confidence siswa SMK. Pendekatan dalam penelitian ini adalah pendekatan kuantitatif dengan desain penelitian Quasy Eksperimental Design dan bentuk desain yang diambil yaitu The Nonequivalent Pretest-Posttest Control Group Design. Populasi dalam penelitian ini siswa kelas X dengan sampel sebanyak 2 kelas masing-masing 30 siswa di SMK Sehati Karawang. Pengambilan sampel mengggunakan teknik pusposive sampling maka diperoleh kelas X Keperawatan 1 dan X Keperawatan 2. Teknik pengumpulan data berupa test uraian untuk mengukur kemampuan pemecahan masalah matematis. Hasil analisis data kuantitatif menggunakan uji Independent Sampel t Test dan uji korelasi Pearson Product Moment menunjukan bahwa (1) peningkatan kemampuan pemecahan masalah matematis siswa yang memperoleh model pembelajaran discovery learning lebih tinggi dari pada siswa yang memperoleh model pembelajaran konvensional; (2) Terdapat hubungan peningkatan kemampuan pemecahan masalah matematis siswa yang memperoleh pembelajaran konvensional dengan self confidence; (3) Terdapat hubungan peningkatan kemampuan pemecahan masalah matematis siswa yang memperoleh pembelajaran discovery learning dengan self confidence; (4) self confidence siswa yang memperoleh model pembelajaran discovery learning lebih baik dari pada siswa yang memperoleh model pembelajaran konvensional.
The rheology of interactions between leukocytes, platelets and the vessel wall in thrombo-inflammation
Authors: Nash Gerard B. 
Published: March 2024

Leukocytes and platelets must adhere to the wall of blood vessels to carry out their protective functions in inflammation and haemostasis. Recruitment is critically dependent on rheological variables (wall shear rate and stress, red cell aggregation and haematocrit) which affect delivery to the vessel wall as well as velocities and forces experienced there. Leukocyte recruitment is efficient only up to wall shear rates of about 300 s−1 and usually restricted to low-shear post-capillary venules in inflammation. Being smaller, platelets experience lower velocities and shear forces adjacent to the wall and can adhere at much higher shear rates for haemostasis in arteries. In addition, we found quite different effects of variations in haematocrit or red cell aggregation on attachment of neutrophils or platelets, which also assist their separate recruitment in venules or arteries. However, it has become increasingly evident that inflammatory and thrombotic responses may occur together, with platelets promoting the adhesion and activation of neutrophils and monocytes. Indeed, it is 30 years since we demonstrated that platelets could cause neutrophils to aggregate in suspension and, when attached to a surface, could support selectin-mediated rolling of all leukocytes. Thrombin-activated platelets could further induce neutrophil activation and immobilisation. In some conditions, platelets could bind to intact endothelial monolayers and capture neutrophils or monocytes. Subsequently, we found that extracellular vesicles released by activated platelets (PEV) fulfilled similar functions when deposited on surfaces or bound to endothelial cells. In murine models, platelets or PEV could act as bridges for monocytes in inflamed vessels. Thus, leukocytes and platelets are rheologically adapted for their separate functions, while novel thrombo-inflammatory pathways using platelets or PEV may underlie pathogenic leukocyte recruitment.
Effect of gold-conjugated resveratrol nanoparticles on glioma cells and its underlying mechanism
Authors: Liu Xiaojiang , Guo Zongfeng , Li Jun , Wu Demo , Liu Zhongping , Guan Cheng , Guan Yixiang , Lu Xiaomin 
Published: March 2024

BACKGROUND: Glioblastoma is the most aggressive brain tumor with poor prognosis. Although Resveratrol (Rsv) is known to have therapeutic effects on glioma, the effects of gold-conjugated resveratrol nanoparticles (Rsv-AuNPs) on glioma cells are rarely reported. OBJECTIVE: We aimed to investigate the effects of Rsv-AuNPs on glioma cells and its underlying mechanism. METHOD: Human glioma cell line U87 was treated with different concentrations of Rsv-AuNPs. CCK-8, transwell, and wound healing assay were performed to measure the effects of Rsv-AuNPs on cell proliferation, invasion, and migration ability, respectively. Flow cytometry assay was used to detect the effects of Rsv-AuNPs on apoptosis. Changes of protein expressions related to proliferation, invasion, migration, and apoptosis were measured by Western blot assay. In addition, the inhibitory role of Rsv-AuNPs in the PI3K/AKT/mTOR signaling pathway was verified by using PI3K inhibitor LY294002. RESULTS: Rsv-AuNPs treatment significantly suppressed proliferation, migration, and invasion of U87 cells (all P < 0.05) and increased the apoptosis rate (P < 0.05). The changes of proteins related to proliferation, migration, invasion and apoptosis were consistent (all P < 0.05). Moreover, Rsv-AuNPs treatment significantly inhibited the phosphorylation of PI3K, AKT and mTOR proteins in U87 cells (P < 0.05). CONCLUSION: The present study found that Rsv-AuNPs inhibited the proliferation, migration, and invasion of U87 cells and induced apoptosis by inhibiting the activation of PI3K/AKT/mTOR signaling pathway. In the future, Rsv-AuNPs might be applied to the clinical treatment of glioma through more in-depth animal and clinical research.
Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer’s Disease: A Systematic Review and Network Meta-Analysis
Authors: Terao Itsuki , Kodama Wakako 
Published: March 2024

Background: The Food and Drug Administration (FDA) has approved lecanemab and aducanumab and is reviewing donanemab, but they have questionable efficacy, serious side effects and are costly, whereas melatonin administration and aerobic exercise for a short time may overcome these problems. Objective: We aim to compare the efficacy on cognitive function, tolerability and acceptability of melatonin administration and aerobic exercise for a short time with donanemab, lecanemab, and aducanumab in people with mild AD and MCI. Methods: We systematically reviewed relevant randomized placebo-controlled trials (RCTs) in PubMed, the Cochrane Library, CINHAL, and ClinicalTrials.gov and performed network meta-analyses. Results: The analysis included 10 randomized placebo-controlled trials with 4,599 patients. Although melatonin and aerobic exercise for a short time were significantly more effective than donanemab, lecanemab, aducanumab and placebo in the primary analysis, there was significant heterogeneity. In the sensitivity analysis excluding exercise, melatonin was significantly more effective than donanemab, lecanemab, aducanumab and placebo, with no significant heterogeneity. Aerobic exercise for a short time was significantly less acceptable than donanemab, aducanumab and placebo. Donanemab, lecanemab, and aducanumab were significantly less tolerable than placebo and donanemab and lecanemab were significantly less acceptable than placebo. CONCLUSIONS: Melatonin may be a better potential disease-modifying treatment for cognitive decline in mild AD and MCI. Aerobic exercise for a short time might also be better than donanemab, lecanemab and aducanumab if continued, as it is well tolerated and more effective, although less valid due to heterogeneity. Another limitation is the small number of participants.
White Matter Microstructure Analysis in Subjective Memory Complaints and Cognitive Impairment: Insights from Diffusion Kurtosis Imaging and Free-Water DTI
Authors: Bergamino Maurizio , Keeling Elizabeth , McElvogue Molly , Schaefer Sydney Y. , Burke Anna , Prigatano George , Stokes Ashley M. 
Published: March 2024

Background: Dementia is characterized by a cognitive decline in memory and other domains that lead to functional impairments. As people age, subjective memory complaints (SMC) become common, where individuals perceive cognitive decline without objective deficits on assessments. SMC can be an early sign and may precede amnestic mild cognitive impairment (MCI), which frequently advances to Alzheimer’s disease (AD). Objective: This study aims to investigate white matter microstructure in individuals with SMC, in cognitively impaired (CI) cohorts, and in cognitively normal individuals using diffusion kurtosis imaging (DKI) and free water imaging (FWI). The study also explores voxel-based correlations between DKI/FWI metrics and cognitive scores to understand the relationship between brain microstructure and cognitive function. Methods: Twelve healthy controls (HCs), ten individuals with SMC, and eleven CI individuals (MCI or AD) were enrolled in this study. All participants underwent MRI 3T scan and the BNI Screen (BNIS) for Higher Cerebral Functions. Results: The mean kurtosis tensor and anisotropy of the kurtosis tensor showed significant differences across the three groups, indicating altered white matter microstructure in CI and SMC individuals. The free water volume fraction ( f) also revealed group differences, suggesting changes in extracellular water content. Notably, these metrics effectively discriminated between the CI and HC/SMC groups. Additionally, correlations between imaging metrics and BNIS scores were found for CI and SMC groups. Conclusions: These imaging metrics hold promise in discriminating between individuals with CI and SMC. The observed differences indicate their potential as sensitive and specific biomarkers for early detection and differentiation of cognitive decline.
Design of signage guidance system for tourist attractions based on computer vision technology
Authors: Zhang Yiheng , Diao Weiqing , Nie Yong , Wang Qin 
Published: March 2024

In order to improve tourists’ sense of touring experience, this research proposes a signage navigation system for mobile scenic spots. Firstly, the system uses a recurrent neural network algorithm incorporating convolutional neural network for image recognition function to obtain relevant information through image recognition. Then the target localization of the image is performed according to the single-stage target detection algorithm, and the location of the landscape in which the user is located is localized by the recognized image information. The results show that the algorithm can achieve 86.7% recognition accuracy, and it can recognize part of the image samples when the recognition time reaches the range of 0.8 min–1 min. The single-stage target detection algorithm has a localization accuracy of 97.2% with a minimum loss rate of 1.1%. And the algorithm has high average accuracy and full class average accuracy values. The system has good application value.
REGISTRO DE OCORRÊNCIA DE Himantura schmardae (CHONDRICHTHYES: DASYATIDAE) NA COSTA NORTE DO BRASIL
Authors: De Almeida Maurício Pinto , Almeida Patricia Charvet , Rincon Getulio , Barthem Ronaldo 
Published: March 2024

A distribuição das espécies do gênero Himanturaé conhecida para a região do Indo-Pacífico e América Central (Oceanos Atlântico e Pacífico) em águas doces e estuarinas. Este é o primeiro registro do gênero e da espécie Himanturaschmardae na costa do Brasil. Quatro exemplares desta espécie foram capturados em diferentes pescarias com rede-de- arrasto de fundo nos meses de setembro de 1996 e abril de 1997 na foz do Rio Amazonas. Um exemplar macho imaturocom comprimento total de 128 cm e largura de disco de 54 cm encontra-se depositado na Coleção Ictiológica do Museu Paraense Emílio Goeldi (número de registro MPEG 3547). A espécieH. schmardae é conhecida pelo nome vulgar eminglês de chupare stingray e regionalmente recebe nome de arraia-redonda. O registro de ocorrência desta espécie na foz do Rio Amazonas pode ser significativo para auxiliar a esclarecer uma das hipóteses sobre a origem das raias de água doce(Potamotrygonidae).
REGISTRO DA OCORRÊNCIA DO TUBARÃO-DUENDE, Mitsukurina owstoni JORDAN, 1898 (LAMNIFORMES: MITSUKURINIDAE) NA REGIÃO NORTE DO BRASIL
Authors: Holanda Francisco Carlos A. Fonteles , Filho Mutuso Asano 
Published: March 2024

O tubarão-duende, Mitsukurina owstoni Jordan, 1898, é uma espécie que habita águas profundas, raramente sendo vista ainda com vida. Pertence à família Mitsukurinidae, atinge até 4 m de comprimento e é encontrado em zonas com até 1.200 m de profundidade. Para o desenvolvimento desta pesquisa, as pescarias foram realizadas na plataforma e no talude continental da região Norte do Brasil, com arrastos em profundidades entre 236 m e 1.246 m. As estações distribuídas nesta região estão entre as latitudes 01º23N e 05º09’N. As operações de arrasto de profundidade foramrealizadas em barcos de pesca, nos períodos agosto de 2002 a maio de 2003, e junho de 2003 a julho de 2004, tendo-se utilizado cinco diferentes tipos de rede. Entre as espécies de peixes cartilaginosos, em cinco lances realizados na costa norte, foram capturados seis exemplares do tubarão-duende. Entre o material coletado durante as pescarias e enviado para uma coleção ictiológica, constam 14 registros fotográficos com os respectivos dados da captura e um exemplar do tubarão-duende (o único da América do Sul).
Современные методы ІТ технологий в учебном процессе для бакалавров
Authors: Нуркасымова Сауле 
Published: March 2024

Технологические проектирования рассматривается как качество преподавания, проявляющееся в виде способности и готовности ее к учебному процессу. Понятия "технология" в современной педагогике является, недостаточно устоявшимся для выражения высокого профессионализма и квалификации специалиста.
FENOMENA CULTURE SHOCK DAN HAMBATAN KOMUNIKASI PADA MAHASISWA KUKERTA INTERNASIONAL DI THAILAND
Authors: Yulinda Linda , Umdatul Hasanah  , Nur Asia  
Published: March 2024

Presiden AECI (Assosiation of Education Cultural International), Takeem Kundee dibawah naungan OIA (Office of International Affairs) director AECI, Buya Amran Jehson mengadakan program KKN/PPL di Thailand Selatan dengan mengirimkan enam universitas dari Indonesia, salahsatunya yaitu Universitas Islam Negeri Sultan Maulana Hasanuddin Banten yang mewakilkan empat mahasiswa dari tiga delegasi mahasiswa fakultas Tarbiyah dan Keguruan, dan satu delegasi mahasiswa fakultas Dakwah. Melaksanakan Kuliah Kerja Nyata (KUKERTA) internasional di Krabi, Thailand selama satu bulan tidaklah mudah bagi mahasiswa KUKERTA karena setiap individu merasakan banyak sekali hambatan khususnya dalam komunikasi antarbudaya sehingga mengalami gegar budaya (culture shock) yang dihadapi mahasiswa selama berada di Thailand. Maka dari itu, tujuan dari penelitian ini ialah untuk mendeskripsikan proses terjadinya culture shock pada mahasiswa serta mengetahui bagaimana hambatan komunikasi yang dialami mahasiswa dalam berinteraksi selama melaksanakan KUKERTA internasional di Thailand. Metode yang digunakan dalam penelitian ini ialah metode kualitatif dengan jenis pendekatan deskriptif sedangkan yang menjadi informan ialah para mahasiswa yang melaksanakan Kuliah Kerja Nyata (KUKERTA) di Thailand selama satu bulan. Hasil penelitian ini menunjukan bahwa faktor bahasa menjadi hambatan utama dalam berinteraksi dengan masyarakat Thailand karena perbedaan bahasa serta mayoritas mahasiswa menyadari akan banyaknya perbedaan budaya asal dengan budaya baru sehingga mengakibatkan munculnya culture shock yang terjadi pada setiap individu dengan jangka waktu tertentu.
STRATEGI DAKWAH FORUM KOMUNIKASI DA’I MUDA INDONESIA (FKDMI) DALAM MENINGKATKAN KREDIBILITAS DA'I DI PROVINSI BANTEN
Authors: Syahriyan Muhamad , Darojatun Rina 
Published: March 2024

Abstrak
Organisasi dakwah diperlukan untuk membentuk sosok seorang da'i yang berkualitas dan memiliki kredibilitas yang baik serta memiliki strategi dakwah yang efektif untuk membina, mengkader, mendidik, membimbing dan melatih seorang da'i agar kredibilitasnya dapat meningkat. Forum Komunikasi Da'i Muda Indonesia (FKDMI) adalah organisasi yang bersifat resmi yang bergerak di bidang dakwah dan bertugas untuk memberikan ilmu pengetahuan, wawasan, pengalaman dan ajaran agama, serta melatih para kader da'i muda yang berbakat. Tujuan dari penelitian ini adalah mengetahui strategi dakwah yang dilakukan oleh Forum Komunikasi Da'i Muda Indonesia (FKDMI) Provinsi Banten dalam meningkatkan kredibilitas da'i dalam berdakwah. Mengetahui faktor-faktor yang menjadi pendukung dan penghambat Forum Komunikasi Da'i Muda Indonesia (FKDMI) Provinsi Banten dalam meningkatkan kredibilitas da'i dalam berdakwah. Penelitian ini menggunakan metode penelitian kualitatif deskriptif. Teknik pengumpulan data yang dilakukan dalam penelitian ini adalah dengan cara observasi, wawancara dan dokumentasi. Berdasarkan hasil penelitian, maka dapat disimpulkan bahwa Forum Komunikasi Da'i Muda Indonesia (FKDMI) Provinsi Banten dalam upaya meningkatkan kredibilitas para da'i di Provinsi Banten telah melakukan ketiga strategi peningkatkan kredibilitas komunikator (da'i) yang dikemukakakan oleh Aristoteles yaitu Ethos, Pathos dan Logos melalui kegiatan-kegiatan yang ada dalam program kerja Forum Komunikasi Da'i Muda Indonesia (FKDMI) Provinsi Banten. Adapun faktor pendukungnya adalah para Da'i, Kiyai, Ustadz, Penyuluh Agama, Masyarakat, Majlis Ulama Indonesia (MUI) Provinsi Banten, Kementerian Agama Provinsi Banten, Polisi Daerah (Polda) Banten dan Lembaga-Lembaga ataupun Instansi lainnya yang memiliki kerja sama dan hubungan baik dengan Forum Komunikasi Da'i Muda Indonesia (FKDMI) Provinsi Banten. Adapun Faktor penghambatnya yaitu terletak pada pembiayaan dan kondisi infrastruktur.
Kata Kunci : Strategi, Dakwah, Kredibilitas Da’i.
PELAYANAN PUBLIK BERBASIS HAK ASASI MANUSIA (HAM) BAGI WARGA BINAAN PEMASYARAKATAN DI RUMAH TAHANAN NEGARA KELAS II KEFAMENANU
Authors: Bulla Demris , Pala Aplonia , Agustian Dimas 
Published: March 2024

Penelitian ini bertujuan untuk mendeskripsikan, menganalisa pelayanan publik berbasis Hak Asasi Manusia bagi Warga Binaan Pemasyarakatan di Rumah Tahanan Negara Kelas IIB Kefamenanu. Metode penelitian yang digunakan adalah Kualitatif. Hasil penelitian menunjukkan bahwa Indikator kemudahan pelayanan yakni terdapat SOP turunan yang dipakai seluruh Rutan/Lapas, terdapat kemudahan akses mendapatkan pelayanan serta adanya fasilitas penunjang pelayanan bagi seluruh WBP baik itu yang normal maupun bagi mereka yang termasuk dalam kelompok rentan serta kaum difabel. Indikator Pelayanan yang wajar sudah diterapakan dengan optimal dibuktikan dengan senyum sapa dan salam yang selalu diberikan petugas. Indikator perlakuan yang sama terbukti dari pelayanan yang diberikan tanpa memilihdan memilah latar belakang usia, status dan golongan, penyediaan tempat ibadah untuk seluruh umat beragama sebagai jaminan untuk masyarakat dapat beribadat menurut keyakinannya, serta indikator pelayanan yang jujur berupa kesedian petugas untuk dikritik dengan adanya layanan pengaduan yang disediakan sebagai bentuk transparansi dalam pelayanan, kerja sama dengan Pemerintah Kabupaten Timor Tengah Utara dalam pemberian pelayanan kesehatan merupakan upaya untuk menjamin hak dalam mendapatkan pelayanan kesehatan yang layak. Hal ini menunjukan bahwa sudah diterapkanya prinsip kesamaan hak, non diskriminasi serta tanggung jawab negara dalam menyelenggarakan pelayanan publik bagi WBP di Rutan Kelaas IIB Kefamenanu.
ANALISIS KINERJA DAN KEPUASAN PELAKSANAAN PROGRAM PADAT KARYA MELALUI PENDEKATAN KUANTITATIF PADA PEKERJAAN PEMELIHARAAN JALAN SP3. WAKOKO - LASALIMU - KAMARU
Authors: Hardiansyah Utomo Pranata , Kadir Abdul , Ahmad Siti Nurjanah , Arsyad Laode Muh. Nurrakhmad 
Published: March 2024

Program padat karya dalam pekerjaan pemeliharaan jalan banyak menyerap tenaga kerja, baik pengangguran, setengah pengangguran, dan menggunakan peralatan sederhana, adapun kegiatan yang dilaksanakan tidak memerlukan keterampilan khusus Kegiatan program padat karya dalam pemeliharaan jalan meliputi pembersihan saluran (drainase), pembersihan bangunan pelengkap (jembatan), pembersihan pelengkapan jalan (patok dan rambu), pengecetan sederhana kerb/median, pengecetan sederhana pada jembatan dan pengendalian tanaman/pemotongan rumput pada bahu jalan, penelitian ini bertujuan untuk mengetahui kinerja pelaksanaan program padat karya pada pekerjaan pemeliharaan jalan SP.3 Wakoko – Lasalimu – Kamaru.
Analisi dilakukan dengan menghitung Impottance Performance Analysic (IPA) dan Customer Satisfaction index (CSI) hasil penelitian diperoleh nilai indeks kepuasan rata-rata responden pada kinerja pelaksanaan program padat karya pekerjaan pemeliharaan jalan SP.3 Wakoko – Lasalimu – Kamaru terhadap 17 (tujuh belas) indikator sebesar 70,92 persen masuk kriteria puas. Faktor-faktor yang menjadi prioritas utama yang perlu ditingkatkan kinerja pelaksanaannya pada program padat karya pada pekerjaan pemeliharaan jalan SP.3 Wakoko – Lasalimu – Kamaru yaitu penerapan keselamatan kesehatan kerja (K3), pelaksanaan sosialisasi, dan pemahaman setelah sosialisasi.

Kata Kunci: Menghitung Impottance Performance Analysic (IPA) dan Customer Satisfaction index (CSI).
Load transfer in bone after partial, multi-compartmental, and total knee arthroplasty
Authors: Stoddart Jennifer C. , Garner Amy , Tuncer Mahmut , Amis Andrew A. , Cobb Justin , van Arkel Richard J. 
Published: March 2024

Introduction: Arthroplasty-associated bone loss remains a clinical problem: stiff metallic implants disrupt load transfer to bone and, hence, its remodeling stimulus. The aim of this research was to analyze how load transfer to bone is affected by different forms of knee arthroplasty: isolated partial knee arthroplasty (PKA), compartmental arthroplasty [combined partial knee arthroplasty (CPKA), two or more PKAs in the same knee], and total knee arthroplasty (TKA).Methods: An experimentally validated subject-specific finite element model was analyzed native and with medial unicondylar, lateral unicondylar, patellofemoral, bi-unicondylar, medial bicompartmental, lateral bicompartmental, tricompartmental, and total knee arthroplasty. Three load cases were simulated for each: gait, stair ascent, and sit-to-stand. Strain shielding and overstraining were calculated from the differences between the native and implanted states.Results: For gait, the TKA femoral component led to mean strain shielding (30%) more than three times higher than that of PKA (4%–7%) and CPKA (5%–8%). Overstraining was predicted in the proximal tibia (TKA 21%; PKA/CPKA 0%–6%). The variance in the distribution for TKA was an order of magnitude greater than for PKA/CPKA, indicating less physiological load transfer. Only the TKA-implanted femur was sensitive to the load case: for stair ascent and gait, almost the entire distal femur was strain-shielded, whereas during sit-to-stand, the posterior femoral condyles were overstrained.Discussion: TKA requires more bone resection than PKA and CPKA. These finite element analyses suggest that a longer-term benefit for bone is probable as partial and multi-compartmental knee procedures lead to more natural load transfer compared to TKA. High-flexion activity following TKA may be protective of posterior condyle bone resorption, which may help explain why bone loss affects some patients more than others. The male and female bone models used for this research are provided open access to facilitate future research elsewhere.