bluuebunny/crossref_metadata_2025_split huggingface dataset:
Staging laparotomy in Hodgkin's disease: A community hospital experience
Authors: Jones A. R. , Ruether J. D. , Ruether B. A. 
Published: February 2007

AbstractBetween 1977 and 1984, 50 patients with Hodgkin's disease underwent a staging laparotomy performed by nine surgeons in a community hospital. Adequate procedures were performed in 80% of cases compared to staging laparotomies done between 1969 and 1976 when only 40% were properly performed. Abdominal lymphangiogram had a false‐negative rate of 0 but a false positive rate of 70%. Clinical stage III disease was significantly downstaged at laparotomy (65% of cases). Postoperative complication rate was 4% and there were no operative deaths. A subset of patients not requiring laparotomy have been identified. Because the quality of staging laparotomy and lymphangiography was variable, we encourage all centres treating patients with Hodgkin's disease to review their own experience with these techniques before making individual patient treatment decisions.
Ornithine decarboxylase levels in the rectal mucosa of patients with colonic neoplasia
Authors: Koo Harry B. , Sigurdson Elin R. , Daly John M. , Berenson Mark , Groshen Susan , Decosse Jerome J. 
Published: February 2007

AbstractOrnithine decarboxylase (ODC) activity in biopsy specimens of normalappearing rectal mucosa was measured in 15 control patients, 5 patients with colon adenomas, and 11 patients with colon cancer. While women had significantly higher ODC activity than men, ODC activity was increased regardless of gender in the rectal mucosal biopsies of patients with benign or malignant colonic neoplasia compared with those of controls. The positive predictive value of ODC activity for remote colonic neoplasia was 61 % for women and 91 % for men. The results provide a rationale for long‐term studies of ODC activity in rectal mucosa as a biological marker of high risk for large bowel neoplasia.
A role for topical 5‐fluorouracil therapy in melanoma
Authors: Ryan Robert F. , Krementz Edward T. , Litwin Martin S. 
Published: February 2007

AbstractTopical 5‐fluorouracil (Efudex®) has been shown to be of great value in the treatment of skin cancers, Marjolin ulcers, and advanced squamous cell carcinoma of the mouth and esophagus. It has been advocated for use on patients with melanocytic dysplasia and lentigo maligna melanoma. This report confirms the use of topical 5‐FU for lentigo maligna melanoma and melanocytic dysplasia. In melanomas with poor prognosis, preoperative treatment with topical 5‐FU converts the cellular infiltrate from acute inflammatory cells to round cells which have been shown to be T‐cells. We believe this preoperative stimulation of the patients' own immune reaction to the tumor may be of great significance in improving the surgical results for melanomas with a poor prognosis.
Nerve sheath tumors of the sciatic nerve and sacral plexus
Authors: Benzel Edward C. , Morris Don M. , Fowler Marjorie R. 
Published: February 2007

AbstractEight patients with sciatic nerve and sacral plexus nerve sheath tumors, seen at Louisiana State University Medical Center in Shreveport, are presented. These cases illustrate the broad spectrum of pathology and modes of presentation of patients with nerve sheath tumors in this region. Patients can be divided into 4 groups. Group I includes subgluteal and/or thigh lesions with a well‐defined mass on CT. Group II patients have neuroforaminal enlargement (defined by CT) and usually have radicular leg pain. Patients in group III have intrapelvic tumors with extension into the thigh.They usually have a poorly defined mass on CT. Group IV includes patients that have an intrapelvic mass (usually well defined) with radicular leg pain and/or mass effect.CT scanning proved to be the diagnostic procedure of choice. It delineated the location and extent of the tumor and thus was important in determining resectability. The variable course of these tumors is emphasized. A conservative nonoperative approach should be considered in asymptomatic and/or neurologically stable patients.
Angiosarcoma of the breast: Long‐term survival following adjuvant chemotherapy
Authors: Rosner Dutzu 
Published: February 2007

AbstractThe present study represents the first attempt of treating primary angiosarcoma of the breast with adjuvant vinblastine sulfate (Velban) resulting in long‐term survival with no evidence of disease in two patients. The rationale for using Velban as adjuvant therapy was based primarily on a prior study where the intratumoral administration of Velban into a large fungating recurrent angiosarcoma lesion resulted in eradication of tumor and also on the recognized responses of Kaposi's sarcoma to intralesional or systemic Velban administration. Patients received Velban at a dose of 4 mg/week for 15 and 12 months postoperatively. Both patients remain disease free at 12 and 10 years, respectively. Our data suggest that adjuvant therapy with Velban appears to alter significantly the clinical course of angiosarcoma of the breast.
In vivo determinations of labelling index of metastatic colorectal carcinoma and normal colonic mucosa using intravenous infusions of bromodeoxyuridine
Authors: Khan S. , Raza A. , Petrelli N. , Mittleman A. 
Published: February 2007

AbstractIn vivo determination of the labelling index of metastatic colon carcinoma was performed in 14 patients following intravenous infusion of bromodeoxyuridine (BrdU), at doses of 100 and 50 mg/M2. No toxicity was seen. Labelled cells were detected by an immunohistochemical technique using a monoclonal antibody to BrdU. Labelling was uniform and highly specific with good preservation of morphology. Labelling index values ranged from 15.0–40.6% for metastatic lesions and 3.6%–20% for normal colonic mucosa, with mean values of 24% and 11%, respectively. This represents a useful new method for in vivo labelling index determination in solid tumors.
Concomitant abdominal aortic aneurysm and malignant disease: A difficult management problem
Authors: Morris Don M. , Colquitt John 
Published: February 2007

AbstractMedical records of 158 patients with abdominal aortic aneurysms seen between 1972 and 1984 were reviewed. Twenty patients, or 12.6%, had a histologically proven malignant neoplasm in addition to their aneurysm. The mean age of patients with cancer was 69 yr and for those without cancer, 68 yr. The most common cancers in this study were prostate, colorectal, and lung. Patients were placed in five categories according to the chronological presentation of the malignancy in relation to the aneurysm. Our study indicated that the incidence of malignant disease associated with abdominal aortic aneurysms is increasing. Absolute indications for operation initially on the aneurysm are the presence of symptoms or rupture. Absolute indications for operation initially on the malignancy are complications from the presence of the tumor such as hemorrhage, perforation, or obstruction. The type and stage of the cancer are major factors in determining operative treatment and priorities.
Ataxia telangiectasia and acinic cell carcinoma of the parotid gland
Authors: Mock Charles , Coleman George , Ree John H. , Abuelo Dianne N. , Crowley James P. 
Published: February 2007

AbstractAn increased incidence of malignancies occurs in ataxia telangiectasia. These are most frequently hematopoietic in children and epithelial in adults. Both cellular immunodeficiency and chromosome damage have been implicated in their etiology. There has been only one report of a salivary malignancy, a parotid mucoepidermoid carcinoma. We describe a second salivary malignancy, a metastasizing acinic cell carcinoma of the parotid gland, that developed in a 33‐yr‐old woman with ataxia telangiectasia. The marked chromosomal abnormalities that were present may have been involved in the pathogenesis of her tumor.
Plasma ultrafiltration as successful therapy of rabbit VX‐2 carcinoma
Authors: Snyder L. M. , Kar R. , Wile Alan G. 
Published: February 2007

AbstractIt has been demonstrated that tumor‐bearing animals elaborate a low molecular weight ( < 10,000 daltons) factor capable of inhibiting in vitro lymphocyte function. It was postulated that removal of this factor would have a favorable effect on host immune response that would translate into improved tumor control. A study was conducted in rabbits bearing the VX‐2 carcinoma. Ultrafiltration (UF) was performed 10 days following IV tumor inoculation. UF was achieved by passing blood through an Amicon Diafilter® (molecular weight cutoff 10 kD) positioned between the arterial and venous cannulae after heparinization. Two plasma volumes of ultrafiltrate were removed with continuous saline replacement. Two groups of animals received the nonspecific immunoadjuvant, Detox, at time of therapy. Survival in the UF group (N = 9) was compared to untreated tumor‐bearing animals (N = 10), sham‐operated animals (N = 6), animals receiving Detox (N = 7), and animals receiving UF plus Detox (N = 6). UF imparted a survival advantage when compared to controls (mean 35 days vs. 25 days, P <.01). The sham group had survival identical to controls. Detox alone conferred minimal survival advantage (mean 29 days, P >.05). However, UF + Detox demonstrated maximal survival benefit (mean 40 days, P <.01). We conclude that UF is an effective anticancer modality in this preclinical model. This study suggests that efforts aimed at eliminating suppressor molecules in cancer patients may be of benefit, especially when combined with biological response modifiers such as Detox.
Combination chemotherapy with carboplatin and bleomycin for advanced and recurrent head and neck cancer: A phase II study
Authors: Gonzalez‐Vela Jose L. , Panasci Lawrence , Black Martin , Pollak Michael , Margolese Richard 
Published: February 2007

AbstractCarboplatin is a platinum analogue with activity reported in head and neck cancer. We conducted a phase II trial with 14 patients who had recurrent head and neck cancer. They were treated with carboplatin 300 mg/m2 intravenously (I.V.) and bleomycin 30 units I.V. every 4 weeks. No responses were observed in this group of patients. Dose intensity of carboplatin administration may be an important determinant of response.
Amplification of the c‐myc proto‐oncogene in cervical carcinoma
Authors: Baker Vicki V. , Hatch Kenneth D. , Shingleton Hugh M. 
Published: February 2007

AbstractAmplification without structural rearrangements of the c‐myc proto‐onco‐gene was found in 14 of 44 primary cervical neoplasms. There was no apparent correlation with stage of disease or degree of cellular differentiation. The prognostic significance of c‐myc amplification cannot be determined from this study.
Cystosarcoma phyllodes metastatic to the mandible
Authors: Abemayor Elliot , Nast Cynthia C. , Kessler David J. 
Published: February 2007

AbstractCystosarcoma phyllodes of the breast appears to encompass a diverse group of tumors with variable clinical behaviors. Although the tumor can behave in a malignant fashion, metastases to the head and neck region are distinctly uncommon. A case is presented of a solitary metastasis to the mandible appearing 1 year after mastectomy and in the absence of widespread disease. The metastatic potential of this neoplasm is discussed and involvement of the head and neck region is reviewed.
Glucagonoma presenting as morbid obesity
Authors: Martin Franklin M. , Hamilton William , Dons Robert , Cashell Allan W. , Ghosh Bimal C. 
Published: February 2007

AbstractA case is described that represents the only reported patient with glucagonoma syndrome and morbid obesity. The diagnosis of glucagonoma should be considered in any patient with the classic criteria despite weight gain. The criteria for diagnosis of glucagonoma are 1) the presence of a glucagon‐secrcting tumor, 2) hyperglucagonemia, and 3) the clinical manifestations of either necrolytic migratory erythema, glucose intolerance, or hypoaminoacidemia.
Needle localization in occult breast lesions
Authors: Landstrom Jerone , Osgood Geoffrey , Young Shun C. 
Published: February 2007

AbstractA series of 211 women underwent 211 preoperative needle localizations of nonpalpable breast lesions. All mammographic, operative, and pathological data were reviewed. Carcinoma occurred in 10%. Seventeen (81%) were invasive, and four (19%) were noninvasive. Forty‐three percent of the cancers were minimal carcinoma (in situ or an invasive cancer measuring less than 5 mm in size with negative axillary nodes), and 48% were less than 1 cm. Overall, metastasis to axillary lymph nodes occurred in 10%. The mammographic findings of microcalcifications occurred in 81 % of the malignant group and in 33% of the benign group. The combination of microcalcifications in association with an irregular density was only found in the malignant group. We conclude that 1) needle localization enables the early detection of stage I breast carcinoma and 2) the mammographic findings of microcalcifications in association with an irregular density occur only with malignancy in this series.
Surgical salvage for recurrent “early” glottic cancers
Authors: Maipang Tanaphon , Razack Mohamed S. , Sako Kumao , Chen Tah Y. 
Published: February 2007

AbstractA 25‐year retrospective study of 143 early (T1 and T2 NO) glottic cancer patients was done to determine the recurrence rate following initial radiation therapy, the surgical salvage rate, and incidence of cervical lymph node metastases. Radiation therapy gave a 5‐year cure rate of 78% for stage I and 57% for stage II. Total laryngectomy for recurrent squamous cell carcinoma had a 5‐year salvage rate of 66% for stage I and 61 % for stage II recurrent tumors. The overall 5‐year cure rate with initial and second therapy for stage I and stage II glottic cancers was 93% and 83%, respectively.
Primary malignant fibrous histiocytoma of the esophagus
Authors: Geboes K. , de Vos R. , Lomami‐Luakabanga B. , Van Aken E. , Lerut T. , Desmet V. , Vantrappen G. 
Published: February 2007

AbstractA 59‐year‐old man was admitted to the hospital for dysphagia and fever. Esophagogram and upper gastrointestinal endoscopy revealed a polypoid mass in the midesophagus. Subtotal esophagectomy, cervical esophagogastrostomy, and lymph node dissection were performed. The histological diagnosis of the tumor was malignant fibrous histiocytoma. An area of severe epithelial dysplasia was found in the esophageal mucosa 3 cm under the tumor.
Retrovesical squamous cell carcinoma associated with toxoplasmosis: Diagnostic images, serum detection of SCC‐antigen, and successful treatment by M‐VAC regimen
Authors: Tada Koji , Takeuchi Toshimi , Tanaka Takuji , Iwata Hideki , Kanematsu Minoru , Kuriyama Manabu , Ban Yoshihito , Kawada Yukimichi 
Published: February 2007

AbstractA case of retrovesical squamous cell carcinoma associated with acquired toxoplasmosis is presented. To date only six cases with retrovesical carcinoma have been reported in the literature. Although it is difficult to make a preoperative diagnosis of this rare neoplasm, transrectal longitudinal ultrasonography was diagnostically valuable, and serial measurements of serum squamous cell antigen (SCC‐Ag) were useful for monitoring the clinical course.
Multiple primary cancers in squamous cell cancer of the head and neck
Authors: Kotwall C. , Razack M. S. , Sako K. , Rao U. 
Published: February 2007

AbstractA retrospective review of 832 patients with squamous cell cancer of the head and neck between 1961 and 1985 was carried out to determine the incidence of multiple primary cancers (MPC) at the time of autopsy and the number who died of the second cancer. The overall risk of developing a second MPC of the head and neck, lung, or esophagus from treatment of first head and neck cancer to time of autopsy was 4.04% per year.
Assessment of serial carcinoembryonic antigen: Determinations to monitor the therapeutic progress and prognosis of metastatic liver disease treated by regional chemotherapy
Authors: Quentmeier A. , Schlag P. , Hohenberger P. , Schwarz V. , Abel U. 
Published: February 2007

AbstractIt is difficult, time‐consuming, and expensive to evaluate the therapeutic efficacy of regional chemotherapy of metastatic liver disease by means of imaging procedures. Therefore it was the aim of this study to find out whether serial carcinoembryonic antigen (CEA) determinations yield reliable data on the therapeutic progress and the individual prognosis of these patients. Since there exists no generally accepted modality to assess CEA curves of patients receiving chemotherapy, we developed our own criterion and tested it in a group of 35 patients. For each patient an individual reference level (CEA‐x̄) was fixed which was obtained as the arithmetical mean of serial CEA values taken during the first three courses of chemotherapy (reference time). On the basis of CEA‐x̄ the marker curves of the 35 patients could be divided into two groups. After the reference time the CEA values of group 1 (12 patients) never decreased below CEA‐x̄. Survival of these patients was significantly (P= 0.00001) shorter than that of the 23 patients (group 2) who showed a decrease in their CEA curves below CEA‐x̄ after the reference time. Beyond this it could be observed that the improvement in survival was significantly greater in those patients who showed a CEA decrease below CEA‐x̄ for a prolonged period (3 months). This difference in prognosis is not an artefact due to different pretherapeutic conditions but is a sign of different responses to therapy. The decrease in CEA values below the individual reference level (CEA‐x̄) is a certain sign of the efficacy of the chosen chemotherapy. A continuous rise of the CEA curve above CEA‐x̄ signifies an ineffective intrahepatic chemotherapy or extrahepatic tumor manifestation. In this case an intensive diagnostic workup of the patient and possibly a modification of the therapy are indicated.
Diagnosis and treatment of giant cell tumor in the thoracic spine
Authors: Yan Shang‐Cheng , Xu Qi‐Ming , Lin Jing‐Rong 
Published: February 2007

AbstractA 23‐year‐old woman with incomplete paralysis was operated upon for a giant cell tumor in the thoracic spine. X‐ray films revealed a destruction lesion in the vertebral body of the 12th thoracic vertebra. On the plain thoracic computed tomography scan, the finding was a soap‐bubble appearance with a linear high density area in the mass lesion which destroyed the vertebral body. Preoperative angiography showed no apparent feeding artery to the tumor tissue; preoperative myelography showed incomplete block at the level of the 12th thoracic vertebra. A radical operation was carried out in one stage via a combined antero‐posterior approach. In order to give radiotherapy immediately after operation, a vascular pedicled rib graft was made. This paper discusses the role of thoracic computed tomography scan in the diagnosis of giant cell tumor and the surgical techniques used in treatment.
Myxoid liposarcoma of the spermatic cord
Authors: McFadden David W. 
Published: February 2007

AbstractThe clinical and pathological features of one new and eight previously reported myxoid liposarcomas of paratesticular origin were reviewed. This kind of tumor was seen in an older population (average age 64 years), most of whom had scrotal masses of long duration (average 3.3 years). The tumors are large, usually painless, and are frequently misdiagnosed as hydroceles or inguinal hernias. All patients were treated by radical inguinal orchiectomy and are alive with follow‐ups of 1‐9 years.
Squamous metaplasia with Hashimoto's thyroiditis presenting as a thyroid nodule
Authors: Kobayashi Tetsuro , Okamoto Shigeru , Maruyama Hirohide , Okamura Jun , Takai Shin‐Ichiro , Mori Takesada 
Published: February 2007

AbstractA 59‐year‐old Japanese female presented a well‐limited and movable thyroid nodule. Histologically, the nodule consisted of clusters of squamous cells surrounded by dense connective tissue in Hashimoto's thyroiditis. The squamous cells were well arranged and showed no mitotic figures. We therefore interpreted this nodule as being squamous metaplasia with Hashimoto's thyroiditis rather than squamous carcinoma of the thyroid. There are no previous reports in the literature of nodular formation of squamous metaplasia in the thyroid.
Enhanced detection of preinvasive breast cancer: Combined role of mammography and needle localization biopsy
Authors: Molloy Mark , Azarow Kenneth , Garcia Victor F. , Daniel James R. 
Published: February 2007

AbstractSeveral recent reports have described an increase in the incidence of preinvasive carcinoma of the breast. To determine the incidence of preinvasive breast cancer at our institution, the results of 469 consecutive outpatient breast biopsies performed at Walter Reed Army Medical Center between July 1, 1985, and January 1, 1987, were reviewed. During this time period, 256 biopsies were performed on palpable masses, and 213 needle localization biopsies were performed on mammographically suspicious lesions. The overall incidence of cancer was 15.4%. Needle localization biopsies yielded a diagnosis of cancer in 17.8% of cases, as did 13.3% of biopsies performed on palpable masses. Eight of 38 (21.1%) carcinomas identified by mammography were preinvasive at the time of diagnosis. Only one of 34 (2.9%) cancers identified because of a breast mass was preinvasive. We conclude that screening mammography is an invaluable tool for the detection of preinvasive carcinoma of the breast and that the increased use of mammography will result in an increase in the incidence of detection of this lesion.
Surgical treatment of patients with small cell carcinoma of the lung: A histochemical and immunohistochemical study
Authors: Ishida Teruyoshi , Nishino Toyohiko , Oka Takeshi , Yasumoto Kosei , Sugimachi Keizo , Hara Nobuyuki , Ohta Mitsuo 
Published: February 2007

AbstractThirty‐three patients with small cell carcinoma of the lung were treated surgically, and immunohistochemistry of the cell differentiations was examined in detail. The overall 5‐year survival rate was 38% and the rates in patients with stage I or stage III were 57% and 11%, respectively (P<0.05). Survival rates in patients with the oat cell type and intermediate type were 24% and 44%, respectively, but with no significant difference. This carcinoma seemed to originate from primitive multipotential stem cells, i.e., those of a neuroendocrine or epithelial nature. Histochemically and immunohistochemically, argyrophilic granules and neuron‐specific enolase, neuroendocrine markers, were detected more frequently in the oat cell type rather than in the intermediate type. In contrast, keratin, epithelial membrane antigen, and carcinoembryonic antigen, epithelial origin markers, were present more frequently in the intermediate type than in oat cell type. However, the difference was significant only in case of detection of argyrophilic granules and the carcinoembryonic antigen (P<0.05). Our current recommendation is that surgical resection should be done in the earlier stage in both subtypes. A more favorable prognosis can be expected when adjuvant chemotherapy is prescribed.