bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biliary colic heralding systemic relapse in non‐hodgkin lymphoma
Authors: Doroshow James H. , Sears Harry , Myers Charles E. , Anderson Tom 
Published: February 2007

AbstractThough lymphocytic lymphoma often presents as a disseminated disease, involvement of the gallbladder or biliary tree in the absence of jaundice is very uncommon [1]. A patient with poorly differentiated lymphoma in complete clinical remission after combination chemotherapy experienced repeated episodes of biliary colic; at laparotomy her right‐upper‐quadrant pain was found to be due to lymphomatous involvement of the common bile duct. Recurrence in nodes surrounding the biliary tree heralded by several months the onset of a systemic relapse which did not respond to further cytotoxic therapy.
Squamous cell carcinoma arising in benign adenolymphoma (Warthin's tumor) of the parotid gland
Authors: Baker Michael , Yuzon Daniel , Baker Burton H. 
Published: February 2007

AbstractAdenolymphoma of the parotid gland is a benign tumor occurring primarily in middle‐aged males. Major texts of surgery and pathology state that this tumor is not malignant nor does it undergo malignant degeneration. This report demonstrates squamous cell carcinoma arising in a parotid adenolymphoma in a patient with no other malignancy or previous irradiation to the head and neck.
Fibrosarcoma of nose and paranasal sinuses
Authors: Agarwal M. K. , Gupta S. , Gupta O. P. , Samant H. C. 
Published: February 2007

AbstractInvolvement of nose and maxilla by fibrosarcoma is extremely rare. Only a few cases of fibrosarcoma arising in this region are reported in the world literature. Two cases of fibrosarcoma are described, and the literature relating to this disease entity is briefly reviewed. Salient features helping in the diagnosis and management of fibrosarcoma also are highlighted.
The possibilities of regression analysis application for prognosis in surgical oncology
Authors: Simonov N. N. , Bernstein M. I. 
Published: February 2007

AbstractRegressive computer analysis was used for prognostic evaluation of immediate and long‐term results of radical treatment of gastrointestinal cancer of different localization. The data were derived from 1,630 patients with gastric, colonic, and rectal cancer who were radically operated upon at N.N. Petrov Oncological Research Institute, the USSR Ministry of Health.A prognostic formula was suggested and verified for determination of the period of greatest risk of gastric cancer recurrences and metastases. Formulae were also devised for foreseeing the degrees of postoperative risk in patients with gastric, colonic, and rectal cancer.
Hepatic erythropoietin (Ep) production following double partial hepatectomy in the rat
Authors: Liu Philip , Naughton Brian A. , Kolks Gail A. , Kruger Richard E. , Piliero Sam J. , Gordon Albert S. 
Published: February 2007

AbstractDouble partial hepatectomy (hepx) evokes an elevation in serum erythropoietin (Ep) levels in anephric hypoxic animals when compared to non‐hypoxic or sham hepx controls. But this Ep response is significantly lower than that found in singly hepx, anephric hypoxic rats.Double hepx also induces numerous cytological changes in the liver. Extravascular accumulation of fat, fibrous scarring, localized necroses, and multiple abscesses, as well as decreased vascularity, occur following the second hepx.A humoral factor was detected in the serum of these animals that is capable of inducing hepatic Ep production when injected into normal rats 18 hours before nephrectomy and hypoxia. This factor, termed hepatopoietin (Hp), was previously demonstrated in the venous serum of singly hepx rats. The serum from animals subjected to double partial hepx is not as potent in inducing Ep production as the serum from singly hepx animals. The discrepancies noted between the single and double hepx groups is attributed to the necrotic cytological changes described above.
Evaluation of erythropoietic potential during pathogenesis of the shay chloroleukemia
Authors: Derelanko Michael J. , Khouri Janina A. , Meagher Richard C. , Lobue Joseph , Gordon Albert S. 
Published: February 2007

AbstractTo evaluate the erythropoietic potential of rats during pathogenesis of Shay chloroleukemia (SCL), SCL animals were exposed to hypoxia initiated within two hours postinduction of SCL. Increases in hematocrit (HCT) occurred in both SCL and nonleukemic controls during the first seven days of exposure. This was followed by declines in HCT in hypoxic SCL rats similar to that observed in nonhypoxic SCL animals. HCT of nonleukemic controls remained elevated throughout hypoxic exposure. Results suggested that in SCL, erythropoietic homeostatic response mechanisms are functional prior to terminal phases of this disease, whereas anemia‐producing mechanisms exceed maximum erythropoietic capacity of these animals during later stages of SCL. The HCT of most SCL rats exposed to hypoxia did not fall below 40% before death. This was in contrast to nonhypoxic SCL animals, which became severely anemic in terminal stages. No survival value was observed despite maintenance of red cell mass at or above normal. The pathogenesis of this leukemia was independent of the leukemic animal's erythropoietic potential.
Metastatic basal cell carcinoma
Authors: Scanlon Edward F. , Volkmer Donald D. , Oviedo Miguel A. , Khandekar Janardan D. , Victor Thomas A. 
Published: February 2007

AbstractThe primary mode of spread of basal cell carcinoma is by direct extension. From 1894 to June 1977, 119 cases of metastatic basal cell carcinoma were reported in the world literature. We wish to report five additional cases. It is our feeling that the spread of these tumors is by the interstitial route. It is standard teaching that the interstitial embolic spread of cancer does not occur, but these five cases give strong supporting evidence to the previously reported suggestion that this route of spread may be common. The concept has considerable implications regarding treatment of most cancers.
Anal gland adenocarcinoma presenting as painless scrotal swelling in a 73‐year‐old man: A case report
Authors: Honoré L. H. 
Published: February 2007

AbstractA 73‐year‐old man presented with progressive painless scrotal swelling without systemic, urinary, or anorectal complaints. The scrotal lymphedema was due to massive bilateral metastatic replacement of the superficial inguinal lymph nodes. The primary tumor was an inoperable, rapidly fatal adenocarcinoma arising from the anal glaänads of the upper canal. Thus, in the evaluation of scrotal swelling of obscure etiology in older patients, occult carcinomas of the anal glands must be considered and appropriate steps taken to establish the diagnosis.
A continuous cell line derived from a human primary cutaneous melanoma: Morphologic and karyologic properties
Authors: Nayak Shankar K. , Drogemuller Carol R. , Pilch Yosef H. 
Published: February 2007

AbstractA continuous tissue culture cell line, JD‐MEL, derived from a primary cutaneous human malignant melanoma, is described. The cultured cells retain the characteristic epithelial morphology of the tumor of origin. The malignant nature of the cell line was demonstrated by the lack of contact inhibition, multilayered growth pattern and the ability to produce tumors in athymic BALB/c mice. Chromosome analysis revealed a near tetraploidy. Distinctive marker chromosomes and a female karyotype were present. No recognizable melanin pigment was identified in the cultured cells.
Effect of actinomycin D‐containing lipid vesicles on murine renal adenocarcinoma
Authors: Kedar Amos , Mayhew Eric , Moore Robert H. , Williams Phyllis , Murphy Gerald P. 
Published: February 2007

AbstractForty Balb C/CR mice inoculated with renal cell adenocarcinoma were divided into five groups. Group A (seven animals) received phosphate buffered saline intraperitoneally; group B (seven animals) received free actinomycin D 300 μg/kg IP; group C (nine animals) received lipid vesicles containing actinomycin D 300 μ/kg/kg IP; group D (eight animals) received a mixture of free actinomycin D 300 μg/kg/kg and empty lipid vesicles IP.The median survival of group A was 32 days, of group B 30 days, of group C 45.2 days, of group D 54 days, and of group E 42 days.It is suggested that giving the mixture of the drug and the lipid vesicles produces a balance similar to that found in a vesicle solution containing the actinomycin D. It is also suggested that liposomes slow the absorption of actinomycin D from the peritoneum.
Immunoperoxidase staining for carcinoembryonic antigen in colonic carcinoma, osteosarcoma, and chordoma
Authors: Harrowe David J. , Taylor Clive R. 
Published: February 2007

AbstractAn indirect immunoperoxidase method was used in an attempt to detect carcino‐embryonic antigen (CEA) in 17 well‐differentiated colonic adenocarcinomas, five osteosarcomas, and four chordomas. Fifteen of the adenocarcinomas were positive, and five of them had been fixed and embedded in 1952 and one in 1942. Two other adenocarcinomas from 1942 were not positive. CEA was not demonstrated in any of the osteosarcomas or chordomas.
Effects of enteral and parenteral nutrition on tumor response to chemotherapy in experimental animals
Authors: Daly John M. , Reynolds Harold M. , Copeland Edward M. , Dudrick Stanley J. 
Published: February 2007

AbstractThe effects of oral and intravenous nutrition on host and tumor responses to graded doses of methotrexate (MTX) were evaluated in 150 adult Sprague‐Dawley rats. All animals were inoculated with Walker‐256 carcinosarcoma and were fed a regular diet for ten days before assigning them to three dietary groups. Group I (n = 64) received a constant intravenous infusion of 30% dextrose‐5% amino acids (IVH), group II (n = 64) received an identical solution orally ad libitum, and group III (n = 22) received a regular diet ad libitum. Animals in groups I and II were then divided into three subgroups each that received either 20 mg/kg, 40 mg/kg, or 60 mg/kg of MTX intramuscularly. Ten days later, all surviving animals were killed. Animals fed the 30% dextrose‐5% amino acid diet orally and given 20 mg/kg and 40 mg/kg of MTX lost slightly less body weight when compared with their IVH counterparts. In the 60 mg/kg treatment group, orally fed animals lost 52 gm of body weight compared with 23 gm in IVH animals. IVH rats given 20 mg/kg and 40 mg/kg of MTX demonstrated significant inhibition of tumor growth and decreased tumor weight/body weight ratios when compared with orally fed rats. No improvement in tumor response to 60 mg/kg of MTX was observed, however, when IVH animals were compared with orally fed rats. In a second study, nutrient intake was maintained at a constant level by intravenous infusion in one group and intrajejunal infusion in another group of tumor‐bearing rats. Host and tumor responses to 20 mg/kg of MTX were similar in both groups of animals.
Primary carcinoma of female urethra: Review of 20 cases
Authors: Kamat Murali R. , Kulkarni Jagdeesh N. , Dhumale Rajendra G. 
Published: February 2007

AbstractTwenty patients of primary urethral carcinoma in females are presented. Age group affected was between 40 and 60 years. Vague symptoms in early stage delayed the diagnosis in most patients. Surgery is the treatment of choice for meatal or anterior urethral lesions while combined Radiotherapy and surgery has been suggested as treatment for entire urethral lesions. In the present series 33% three years and 21% five years survivals were noted.
Characterization of Fc receptors associated with human malignant tumors
Authors: Krishnan Engikolai C. , Krishnan Leela , Jewell William R. 
Published: February 2007

AbstractFc receptors from human tumors were isolated by sucrose gradient fractionation and affinity chromatography techniques. The isolated Fc receptors showed specificity for IgG(Fc) in the closed chamber hemadsorption technique and also in the inhibition experiments using radiolabeled Fc receptors. The results indicate that Fc receptors isolated from tumor tissue are similar to Fc receptors isolated from normal human spleen, dog macrophages, and peripheral white blood cells (WBCs). However, the Fc receptors isolated from macrophages are more potent inhibitors when compared with tumor, spleen, and peripheral WBC Fc receptors. Also, Fc receptors isolated from the various sources are independent of species specificity.
Postirradiation malignant fibrous histiocytoma
Authors: Tewfik H. H. , Tewfik F. A. , Latourette H. B. 
Published: February 2007

AbstractThree patients who were treated successfully with postoperative external radiation therapy for ovarian carcinoma, endometrial adenocarcinoma and bilateral retinoblastoma respectively developed years later malignant fibrous histiocytoma (MFH) within the irradiated field.MFH is a recently described soft tissue sarcoma known for its dual fibroblastic and histiocytic differentiation resulting in a pleomorphic histologic appearance.
Radioiodine therapy of carcinoma of the thyroid
Authors: McConnell Robert 
Published: February 2007

AbstractThe discovery of functioning metastases of thyroid carcinoma and their appropriate treatment with radioiodine are the keys to long‐term survival. Functioning metastases can be adequately found only if postsurgical residual normal thyroid tissue is ablated and total body scanning performed. Radioiodine treatment of functioning metastases following appropriate surgery is the treatment of choice, and long‐term follow‐up with total body scanning techniques is most important.
Therapy for Nb rat tumor transplanted in athymic mice
Authors: Drago Joseph R. , Goldman Laurence B. , Worgul Thomas , Gershwin M. Eric 
Published: February 2007

AbstractTwo Nb rat prostatic adenocarcinomas, 13 Pr‐12, an autonomous tumor, and 2 Pr‐128, an androgen‐dependent tumor, were transplanted into groups of congenitally athymic nude mice. The agents used for treatment of these tumors are agents characteristically not used in treatment of prostatic adenocarcinoma in humans. However, these have been efficacious in treating other solid malignancies. Both agents, BCNU and Actinomycin‐D, were efficacious in producing tumor regression and in causing at least a temporary decrease in tumor growth. The combination of the Nb rat prostatic adenocarcinoma model and nude mouse is presented as an appropriate system to screen therapeutic agents that have proved efficacious in treatment of other solid malignancies but have not been used in treating prostatic adenocarcinoma.
Primary treatment of well‐differentiated thyroid cancer
Authors: Block Melvin A. 
Published: February 2007

AbstractOperations for well‐differentiated thyroid carcinoma should be individualized on the basis of the pathologic variety and clinically demonstrated extent of carcinoma. Although precise studies have not been carried out specifically to provide treatment plans for various clinical situations, experience does provide management policies to follow currently. The basic operation is thyroid lobectomy. This appears adequate for minimal carcinoma, small (under 1.5 cm diameter) carcinoma, and low grade encapsulated follicular carcinomas of the thyroid. Extent of operation for other clinical patterns of well‐differentiated thyroid carcinoma is individualized to permit control of the disease in the neck. If well‐differentiated carcinoma is recognized only postoperatively, a decision for reoperation can relate to evidence of multicentricity. Improvements in autotransplantation of parathyroid tissue and diagnostic needle biopsy have permitted improvements in therapy in recent years.
A model of tumor cell dormancy: Effects of anesthesia and surgery
Authors: Varani James , Lovett Edmund J. , Lundy Joel 
Published: February 2007

AbstractThree cloned populations of tumor cells obtained from a murine fibrosarcoma were able to remain viable for a long period of time in syngeneic mice which failed to exhibit clinically evident tumors following tumor cell inoculation. Viable tumor cells under such conditions can be considered to be in a dormant state. On the basis of past studies, two of the lines were shown to have low malignant potential, while the third line was shown to have a higher degree of malignant potential. The rates of spontaneous reactiviation of tumor growth in animals carrying the low malignant cells were 3 and 4%, while a rate of 30% was observed in animals with the more malignant cellw. Treatment of animals carrying the low malignant cells in a dormant state with anesthesia alone, (thiopental) or with anesthesia and surgery, increased the rate of reactivation to 20–22%.
Efforts to explain spontaneous regression of cancer
Authors: Cole Warren H. 
Published: February 2007

AbstractAfter a study of the 176 cases (Everson and Cole) of spontaneous regression of cancer and recent progress in immunology, the author is convinced stimulation of the immune process is the most important factor in S.R. of cancer. Stimulating factors are numerous including bacterial products, enzymes, infections, hormones, trauma, etc. Of the 176 cases reported by Everson and Cole, 71 (40%) were associated with some type of operative trauma.Since the effective anticancer agent interferon is an important protective agent (especially antiviral) in the human body, this product could readily play an important role. Immunoglobulins appear to be possible factors. The blocking and unblocking agents of the Hellströms and associates support this supposition. Elimination of carcinogens appears important, considering the remarkable disappearance of cancer of the bladder in 12 of 13 patients having diversion of the urine from the bladder to the colon by transplantation of the ureters from the bladder to the colon.Innumerable antigens unknown to us at the present time could act as stimulants to our immune system, and thus cause regression of cancer. Hormonal factors must obviously be considered, but the author is doubtful that they exert an important role.
Choice of route for central venous cannulation: Subclavian or internal jugular vein? A prospective randomized study
Authors: Kaiser C. William , Koornick Alan R. , Smith Noel , Soroff Harry S. 
Published: February 2007

AbstractThe clinical need for central venous cannulation has been well established. The usual route for catheter placement is by either the subclavian or internal jugular vein. No randomized, prospective evaluation has been yet conducted to determine which of these approaches, if either, is better with respect to reliability, placement, and frequency of nonseptic complications. One hundred consecutive patients requiring elective central venous cannulation were randomized to either the subclavian or internal jugular route. Successful venipuncture and catheter passage were significantly more common with the subclavian route, and in the absence of special clinical situations, it appears to be the route of choice.
Regional chemotherapy via the pulmonary artery for pulmonary metastases
Authors: Karakousis C. P. , Park H. C. , Sharma S. D. , Kanter P. 
Published: February 2007

AbstractRegional chemotherapy with Adriamycin via the pulmonary artery produces significantly higher tissue levels in the infused canine lobe than systemic administration. Seven patients with soft tissue sarcomas who had received the maximum dose of Adriamycin and had shown metastatic tumor recurrence to the lungs, received small doses of 10 to 20 mg of Adriamycin in the lobar arteries supplying areas with tumor via a Swan‐Ganz catheter, temporarily occluding with its inflated balloon the infused artery. One partial objective regression was noted. A total of 56 injections of Adriamycin was given through individual lobar arteries in the seven patients. This preliminary experience indicates the feasibility and relative safety of the use of the pulmonary artery for regional chemotherapy of pulmonary malignant tumors and suggests fuflher cautious exploration of this method.
Anaplastic seminoma: An analysis of eight cases with literature review
Authors: Jose Baby , Perkins Petya Lee , Tobin Daniel A. 
Published: February 2007

AbstractA retrospective analysis of 80 cases of seminomas treated at the University of Louisville Radiation Center from 1958 to 1979 has been done. Eight cases have been treated with a diagnosis of anaplastic seminoma. This study is a review of the eight cases, along with a review of literature, regarding the prognosis and management of anaplastic seminoma.
Flow cytometric analysis of the response of the r3327‐g rat prostatic adenocarcinoma to endocrine manipulation
Authors: Pollack Alan , Bagwell Charles B. , Block Norman L. , Irvin George L. , Claflin Alice J. , Stover Betty J. 
Published: February 2007

AbstractThe technique of flow cytometric DNA histogram analysis (FCM) shows there to be two distinct cell populations (diploid vs aneuploid) in the poorly differentiated R3327‐G rat prostatic adenocarcinoma. The following study compares tumor weight measurements with several FCM computer‐based methods designed to determine rapidly the proliferative status of tumors. Hypophysectomy, bilateral adrenalectomy, orchiectomy, sham operations, or diethyl‐stilbestrol treatments were initiated when the tumors were palpable (day 21) and continued until the tumors were excised (day 52). Hypophysectomy, orchiectomy, adrenalectomy, and diethylstilbestrol treatments all resulted in significant inhibition by tumor weight. Quantitation of the percentage of mid‐S phase aneuploid cells by summation gave the best correlation with tumor weight. Tumors grown in hypophysectomized, orchiectomized, adrenalectomized, or diethylstilbestrol‐treated animals showed a significant reduction in the proportion of mid‐S phase cells as compared with controls. The calculation of the percentage of all aneuploid cells was significantly reduced in hypophysectomy, orchiectomy, and diethylstilbestrol‐treated animals. However, tumors grown in adrenalectomized animals were not significantly different from controls by this method. Adrenalectomy was found to be the least effective form of therapy, and this was reflected in all of the parameters measured. These data show that FCM analysis may be useful in the quantitation of prostatic carcinoma response to therapy.
Spontaneous regression of breast carcinoma: Follow‐up report and literature review
Authors: Ross Michael B. , Buzdar Aman U. , Hortobagyi Gabriel N. , Lukeman John M. 
Published: February 2007

AbstractA case of spontaneous complete regression of metastatic breast carcinoma (malignant pleural effusion and bone metastases) with previously reported from M. D. Anderson Hospital and Tumor Institute. The patient did not receive any form of hormonal manipulation or systemic chemotherapy. This patient has now relapsed after 72 months of spontaneous complete remission, and a follow‐up of her clinical history is presented. A search of the literature for previously reported instances of spontaneous regression of breast carcinoma indicates that this event is exceedingly rare.
Squamous cell carcinoma of the oral cavity in young adults
Authors: Amsterdam James T. , Strawitz Joseph G. 
Published: February 2007

AbstractThe 12 patients less than 35 years of age treated for squamous cell carcinoma of the oral cavity at the American Oncologic Hospital between 1954‐1979 are examined. Group A (eight patients) had involvement of the tongue; Group B (4 patients) had carcinoma of other oral sites. Mean “T” stage for Group A and Group B was 1 and 1.5, respectively. Treatment was surgical in the majority of cases. Seventy‐one percent of Group A and 25% of Group B developed metastatic disease to the neck. The 2‐year survival rate was 57% (A) and 75% (B) — 75% combined. The collective results of this and other studies suggest lower control rates than those reported for older patients with similar initial presentations. The implications of this observation are discussed in relation to the management of the younger patient with squamous cell carcinoma of the oral cavity.