bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Validation of an Instrument to Assess Quality and Completeness of Medication‐Related Discharge Documentation
Authors: Bertilsson Emma , Östman Victoria , Cam Henrik , Franzon Kristin , Gillespie Ulrika 
Published: February 2025

ABSTRACTRationaleTransitions of care are periods of heightened risk of medication management errors. Poor‐quality discharge documentation has been linked to incorrect or suboptimal medication use and unplanned hospital visits. Despite regulations defining essential components of medication‐related discharge documentation, deficiencies persist, highlighting the need for a method to assess whether current clinical practice meets these standards.AimsTo conduct an initial validation of a newly developed instrument, the Complete Medication Documentation at Discharge – Measure (CMDD‐M), assessing the quality and completeness of medication‐related discharge documentation in a Swedish clinical setting.MethodsThe instrument was developed and refined in multiple stages. In this study, two clinical pharmacists and one geriatrician independently applied the final instrument to discharge documentation from 50 patients. Inter‐rater reliability (IRR) was evaluated using linear and quadratic weighted Cohen's κ (κWlinear and κWquadratic).ResultsThe average CMDD‐M score, based on the consensus of the three raters, was 3.40 (SD ± 2.50) out of nine possible points across the patients' discharge documentation. The IRR between the pharmacists' individual assessments demonstrated almost perfect agreement, with κWlinear and κWquadratic values of 0.92 (95% CI: 0.80–1.00) and 0.97 (95% CI: 0.85–1.00), respectively. Moreover, the IRR between the pharmacists' consolidated score and the geriatrician's assessment displayed a moderate to strong agreement, with κWlinear and κWquadratic values of 0.64 (95% CI: 0.48–0.80) and 0.80 (95% CI: 0.64–0.97), respectively.ConclusionThe CMDD‐M demonstrated robust IRR confirming its ability to consistently and accurately measure the quality and completeness of medication‐related discharge documentation in an easy‐to‐use form. Further research is recommended to ensure validity, generalisability and association with clinically relevant outcomes supporting the instrument's potential usefulness for evaluating and improving clinical practice and research.
In Vivo Assessment of Plasma Gel: Regenerative Potential and Limitations as a Filler
Authors: Cheng Hao , Li Ju , Zhao Yong , Xia Xun , Li Yan 
Published: February 2025

ABSTRACTBackgroundPlasma gel, also known as plasma‐rich in growth factors (PRGF) gel or platelet‐rich gel, is a novel application of platelet‐rich plasma (PRP), created by heating platelet‐poor plasma (PPP) to induce denaturation, forming a gel‐like substance. This gel is then combined with PRP to create a new injectable biomaterial that offers both the regenerative benefits of PRP and structural support due to its gel‐like consistency. Plasma gel has been increasingly used not only for its biological regenerative properties but also as a cosmetic filler to enhance tissue volume and improve skin aesthetics. It shows promise in facial rejuvenation by improving skin texture and elasticity, and reducing the appearance of wrinkles. However, the detailed in vivo behavior of plasma gel, particularly its absorption rate and regenerative efficacy, remains underexplored.AimsThis study aims to investigate the in vivo behavior of plasma gel, focusing on its absorption rate and its ability to stimulate tissue regeneration. Specifically, we aim to assess how quickly plasma gel is absorbed after subcutaneous injection and to evaluate its effects on collagen production and neovascularization using a nude mouse model.MethodsPlasma gel was prepared by heating PPP to create a gel‐like substance, which was then mixed with PRP. This mixture was injected subcutaneously into nude mice. The absorption of the gel was monitored over time by measuring the remaining volume at different time points. Tissue samples were analyzed using Masson's trichrome staining to detect collagen and CD31 immunohistochemical staining to assess neovascularization to understand the regenerative effects induced by plasma gel.ResultsThe study found that plasma gel is absorbed rapidly, with approximately 50% of the volume disappearing within the first week and almost complete absorption by eight weeks. Despite this rapid absorption, significant increases in collagen deposition and new blood vessel formation were observed, indicating strong regenerative properties even after the gel had been largely absorbed.ConclusionsThe main findings of this study suggest that while plasma gel is quickly absorbed and may not be suitable for long‐term volumizing effects, it shows significant potential for temporary volume enhancement and as a biostimulatory agent. Plasma gel's ability to promote collagen production and neovascularization makes it valuable in clinical applications where temporary support and long‐term tissue regeneration are desired. Future research should focus on ways to extend the retention time of plasma gel and enhance its regenerative effects, potentially through modifications to its formulation or combination with other bioactive substances.
Rhinomodelation With Polycarpolactone—A Safer and Effective Solution for the Future
Authors: Qureshi Kamran Izhar , Vercesi Franco , Qureshi Hina Farooq 
Published: February 2025

ABSTRACTIntroductionNonsurgical rhinoplasty or rhinomodelation is a sought‐after procedure in aesthetic practice. The current product of choice remains hyaluronic acid (HA) because of its ease of use and reversibility. However, it does carry some risks. Polycaprolactone (PCL) fillers hold a lot of promise in aesthetic practice. It has an established safety profile and a longer duration of action. Because of its unique properties, it may hold the key to the future of nonsurgical rhinomodelation.MethodsTwelve patients were enrolled in the study. Ten out of these were not willing to ask for surgery and had no breathing problems. Two were post‐surgical rhinoplasty complications who did not want another surgery. 0.2 mL of PCL filler was injected at each site according to the need (radix, spine, and or tip). The Global Aesthetic Improvement Scale (GAIS; 3 = very much improved, 2 = considerably improved, 1 = improved, 0 = no change, and −1 = worse) was used along with a patient satisfaction scale (highly satisfied, satisfied, dissatisfied) were used. The sum of the GAIS ratings was quantified as total improvement (TMI). The patients were followed up for 12 months before and 12 months after procedures were taken and documented.ResultsThe GAIS score was 98% for the study and all patients were highly satisfied with their treatment right after procedure and 12 months later.ConclusionPCL fillers may be the way forward for long‐term sustained results in nonsurgical rhinomodelation. Expert injection techniques and knowing the side effects and handling them is mandatory.
Effectiveness and Safety of Combined Use of Home‐Based Radiofrequency Device and Arbutin Cream in Melasma and Facial Rejuvenation
Authors: Zhang Lei , Zhao Qian , Che Qilei , Wang Wenju , Chen Tao , Tang Xiao , Zhao Xin , Wang Nianou , Li Ke , Wa Qingbiao 
Published: February 2025

ABSTRACTBackgroundMelasma and facial aging are prevalent dermatological concerns. The combined use of a home‐based radiofrequency (RF) device and a topical depigmentation agent, such as an arbutin‐based cream, has shown potential in addressing both conditions.AimsThis study evaluated the effectiveness and safety of combining a home‐based RF device with arbutin cream to treat melasma and facial aging.MethodsThis single‐center, open‐label study included 38 participants. The treatment involved using a home‐based RF device alongside an arbutin cream three times a week for 4 weeks, followed by a 4‐week rest period. Key outcomes included changes in modified Melasma Area and Severity Index (mMASI) scores, melanin index (MI), erythema index (EI), facial wrinkles, skin texture, and periorbital dermal thickness. The participants also provided a self‐assessment of the treatment efficacy.ResultsAfter 4 and 8 weeks of treatment, compared with baseline, the mMASI scores decreased by 20.8% and 25.6%, whereas the MI decreased by 22.0% and 22.8%, respectively. The EI decreased by 5.94% and 6.86%, facial wrinkles decreased by 30.9% and 35.9%, and skin texture scores decreased by 19.7% and 21.4% at 4 and 8 weeks posttreatment, respectively. Significant improvements in periorbital dermal thickness and subcutaneous tissue thickness were observed after combined RF and arbutin cream treatment. None of the 38 participants experienced adverse events, and all reported satisfaction with the results.ConclusionThe combination of a noninvasive home‐based RF device and arbutin cream is effective in improving melasma and achieving facial rejuvenation, offering a safe and patient‐friendly treatment option.
Innovative minimally invasive technique for pelvic organ prolapse: V‐Notes lateral suspension
Authors: Bulutlar Eralp , Uluutku Bulutlar Gizem Berfin , Boz Izceyhan Gizem , Aktaş Özgür , Albayrak Denizli Ayşe Betül , Kiliççi Çetin 
Published: February 2025

AbstractBackgroundThis study aimed to develop a novel antiprolapse surgical technique utilizing minimally invasive methods with lateral suspension in natural orifice surgeries.AimsThe primary objective of this study was to describe a modified V‐Notes lateral suspension (VNLS) technique as a viable alternative for antiprolapse surgery.Study DesignThis was a prospective clinical trial evaluating a new surgical technique.MethodsPatients indicated for lateral suspension underwent the procedure using the V‐Notes technique through natural orifices. No additional incisions were made on the anterior abdominal wall, except for the mesh exit points.ResultsPost‐operation, the only incisions present were the two lateral mesh outlet incisions on the anterior abdominal wall. Additionally, there was no need for peritonization as the Alexis wound protector/retractor was used extraperitoneally. The outcomes were comparable to those achieved with laparoscopic lateral suspension (LLS). The VNLS technique demonstrated favorable results, including shorter hospital stays and improved cosmetic outcomes compared to traditional LLS. This innovative approach has the potential to become the new gold standard in antiprolapse surgery, providing benefits such as minimal invasiveness and enhanced aesthetics.ConclusionWhile the optimal treatment for pelvic organ prolapse remains undetermined, natural orifice surgeries like V‐Notes offer promising advantages, including reduced invasiveness and superior cosmetic results, suggesting their potential for future standard practice.
Task Profiles of Academically Qualified Psychiatric Nurses in Germany: Results of a Cluster Analysis
Authors: Scheydt Stefan , Nienaber André , Holzke Martin 
Published: February 2025

ABSTRACTIntroductionAs little clarity exists regarding the roles of academically qualified nurses in Germany it is not certain that nurses who call themselves “nursing experts” actually perform the tasks of a nursing expert or APN. An important aspect of the present “Study on the situation of academically qualified nurses in psychiatric care contexts in Germany” (AkaPP study) was therefore to identify profiles or clusters based on the tasks and activities performed by academically qualified psychiatric nurses in Germany.AimTo identify possible clusters of academically qualified psychiatric nurses working in direct care practice, nursing development or nursing research positions in relation to their self‐described tasks and activities.MethodData were collected via an online survey between August and November 2020. The target group of the study was academically qualified nurses in Germany working in a psychiatric‐psychosocial healthcare institution. The group of interest for the analysis was the subgroup of nurses in a “direct care and scientific nursing role” (academically qualified nurses working in direct patient care, nursing development or nursing research positions; n = 105 valid cases). A hierarchical cluster analysis was carried out using the Ward method on the basis of the tasks and activities described by the participants in the questionnaire. The identified clusters were described in terms of descriptive statistics against the background of previously defined content characteristics and compared for noticeable differences. Reporting was performed according to the STROBE checklist.ResultsCluster analysis revealed the following seven clusters of academically prepared nurses: (1) Practice Development and Consultative Expertise, (2) Basic Nursing Practice, (3) Advanced Practice Development and Nursing Research, (4) Specialised and Expanded Psychiatric Nursing Practice, (5) Basic Psychiatric Nursing Practice, (6) Direct Patient Care and Basic Practice Development and (7) Advanced Psychiatric Nursing Practice.Discussion and Implications for PracticeThe clusters identified provide a nuanced understanding of the roles of graduate psychiatric nurses in Germany. This insight helps to tailor staffing structures and training programs to the needs of psychiatric care settings. By delineating distinct role profiles, healthcare institutions and policymakers can optimise resource allocation, enhance interdisciplinary collaboration and ultimately improve patient outcomes. This research provides guidance for refining clinical practice models and promoting professional development in psychiatric nursing contexts.
Management of Hypergranulation Tissue: A Report of a Pediatric Case
Authors: Hurley Margaret , Scott Jennifer , Zaenglein Andrea L. 
Published: February 2025

ABSTRACTHypergranulation tissue is the overgrowth of granulation tissue during the proliferative phase of wound healing. Treatment of hypergranulation tissue in the pediatric patient is focused on efficacious and comfortable options, of which topical steroids have been successfully used. This report discusses management of a large area of hypergranulation and concurrent infection on the scalp of a pediatric patient.
Wielding God's Power: A Framework for Understanding Orthodox Christian‐Muslim Relations
Authors: Dorroll Philip 
Published: February 2025

ABSTRACTOver the past 2 decades, the topic of Christian‐Muslim relations has become one of the most talked‐about issues in the world, and western Christian historical experiences and sources have usually dominated these discussions. Often overlooked is the fact that vast numbers of Eastern and Oriental Orthodox Christians and Muslims have continuously lived among one another from the beginning of Islam in the seventh century up to the present day. This article asserts that a broad analysis of Orthodox Christian‐Muslim relations as a distinct history can reveal insights into the nature of interfaith relationships across time and geographical or linguistic boundaries, highlighting lasting and profound human experiences such as solidarity, spiritual fellowship, traumatic memory, and resistance against injustice. This article will both introduce readers to the key scholarly literature that discusses aspects of this distinct history, and also put these sources into dialog in order to propose ways of approaching this history as a coherent field of study. Specifically, this article argues that theologies of sacred power have structured Orthodox‐Christian Muslim relations across time and space. These theologies are here termed “imperial theologies of sacred power,” and “vernacular theologies of sacred power.” “Imperial theologies of sacred power” refer to the political theological claims that both Orthodox Christian and Muslims empires made to justify their dominance over the other's religious communities as imperial subjects. “Vernacular theologies of sacred power” refers to the relationships that were constructed between members of these communities at the local level when they actively shared sacred spaces and rituals. The concept of “vernacular theologies” is taken from recent theoretical work in Orthodox Christian Studies by Lydia Bringerud (2019), Sarah Riccardi‐Swartz (2020), and Helena Kupari and Elini Vuola (2020) and provides a helpful way forward for the further exploration of the historical contours of interfaith relations in Orthodox Christian contexts.
Evolution of Dispersal in a Stream With Better Resources at Downstream Locations
Authors: Liu Kuiyue , De Tang  , Chen Shanshan 
Published: February 2025

ABSTRACTThis paper is concerned with a two‐species Lotka–Volterra competition patch model over a stream with better resources at downstream locations. Treating one species as the resident species and the other one as a mutant species, we first show that there exist two quantities and depending on the drift rate: if the dispersal rate of the resident species is smaller (respectively, larger) than (respectively, ), then a rare mutant species can invade only when its dispersal rate is faster (respectively, slower) than the resident species. Then, we show that there exists some intermediate dispersal rate, which is the unique evolutionarily stable strategy for the resident species under certain conditions. Moreover, the global dynamics of the model is obtained, and both competition exclusion and coexistence can occur. Our method for the patch model can be used for the corresponding reaction–diffusion model, and some existing results are improved.
Advancing phylogenomic marker design: Updated USCO and UCE databases of Collembola
Authors: Du Shiyu , Zhang Shengyang , Jiang Run , Yu Daoyuan , Godeiro Nerivânia Nunes , Zhang Feng 
Published: February 2025

AbstractMolecular markers are critical for elucidating the evolution and genetic diversity of species. The relentless progress and innovation in sequencing technology have enabled the acquisition of a vast repository of high‐quality organism genomic data. A more precise and high‐resolution set of molecular markers can provide deeper insights into species evolution. Collembola, as a key group of soil arthropods, has been the focus of extensive research due to its evolutionary and ecological importance. Recently, several chromosome‐level genomes of springtails have been sequenced. Our objective was to enhance molecular marker design to improve the accuracy and robustness of the Collembola database, focusing on universal single‐copy orthologues (USCOs) and ultraconserved elements (UCEs). We constructed a set of 4073 USCOs by examining 15 genomes, including 11 high‐quality genome data at the chromosome level. We then curated and adapted a customized BUSCO (Benchmarking Universal Single‐Copy Orthologues) dataset specifically designed for USCO evaluation. In addition, we developed a novel probe set for UCEs, comprising 67,707 baits targeting 2608 specific loci. We achieved the successful capture of 2089–3847 USCOs and 972–1405 UCEs across the 15 genomes under investigation. These markers were tested to assess their capture success and systematically validated against two previous phylogenomic studies. This approach is instrumental in species identification, phylogenomics, population genetics, and contributes significantly to advancing our understanding of evolutionary biology and ecology. Both datasets are freely available for download from figshare: https://doi.org/10.6084/m9.figshare.26839783.
The homological spectrum via definable subcategories
Authors: Bird Isaac , Williamson Jordan 
Published: February 2025

AbstractWe develop an alternative approach to the homological spectrum of a tensor‐triangulated category through the lens of definable subcategories. This culminates in a proof that the homological spectrum is homeomorphic to a quotient of the Ziegler spectrum. Along the way, we characterise injective objects in homological residue fields in terms of the definable subcategory corresponding to a given homological prime. We use these results to give a purity perspective on the relationship between the homological and Balmer spectrum.
A short proof of Helson's conjecture
Authors: Gorodetsky Ofir , Wong Mo Dick 
Published: February 2025

AbstractLet be the Steinhaus multiplicative function: a completely multiplicative function such that are i.i.d. random variables uniformly distributed on the complex unit circle . Helson conjectured that as , and this was solved in a strong form by Harper. We give a short proof of the conjecture using a result of Saksman and Webb on a random model for the zeta function.
On convex bodies in Rn${\mathbb {R}^n}$, n⩾5$n\geqslant 5$, with directly congruent projections
Authors: Sbeih Reema A. 
Published: February 2025

AbstractLet and let and be two convex bodies in such that their orthogonal projections and onto any ‐dimensional subspace are directly congruent, that is, there exists a rotation and a vector such that . Assume also that the 2‐dimensional projections of and are pairwise different and they do not have ‐symmetries. Then and are congruent. We also prove an analogous more general result about twice differentiable functions on the unit sphere in .
Pregnancy does not affect progression of mild experimental asthma in sheepx
Authors: Roff Andrea J. , Davies Andrew N. , Clifton Vicki L. , Stark Michael J. , Tai Andrew , Robinson Joshua L. , Hammond Sarah J. , Darby Jack R. T. , Meakin Ashley S. , Lock Mitchell C. , Wiese Michael D. , Sharkey David J. , Bischof Robert J. , Morrison Janna L. , Gatford Kathryn L. 
Published: February 2025

AbstractAsthma is the most common respiratory condition during pregnancy and increases the risks of adverse pregnancy and perinatal outcomes. Asthma symptoms change in ∼60% of pregnancies, but whether this is due to pregnancy itself is unclear. We tested the hypothesis that physiological changes during pregnancy worsen asthma severity in an ovine experimental model of allergic asthma. Three‐year‐old Merino ewes were randomly allocated to either control or allergic asthma groups. Asthma was induced through sensitisation and repeated airway challenge with house dust mite allergen. We compared airway function, circulating cytokine profile and airway immune response to allergen challenge throughout the study and airway structure between groups, in non‐pregnant (control n = 8, asthma n = 9), singleton‐pregnant (control n = 5, asthma n = 8) and twin‐pregnant ewes (control n = 6, asthma n = 9). Within non‐pregnant animals, transpulmonary pressure at Day 132 of the study was 37% higher in asthmatic than control ewes (P = 0.031), but not different between treatments in singleton‐pregnant (P = 0.594) or twin‐pregnant (P = 0.074) ewes. Between premating and Day 132, dynamic compliance decreased more in asthmatic than control ewes (P = 0.040), and this change did not differ between litter sizes (P = 0.096). Neither asthma nor pregnancy affected eosinophils in bronchoalveolar lavage or lung tissue. There was no evidence of lung airway remodelling in the cohort. The results of this study suggest that pregnancy does not increase asthma symptoms or severity of mild asthma.
imageKey points
Asthma severity changes in ∼60% of pregnancies, but whether this is due to pregnancy itself is unclear.
Using a sheep model of allergic asthma, we tested the hypothesis that physiological changes during pregnancy worsen asthma severity.
Dynamic compliance decreased to a greater extent in asthmatic than control ewes over the course of the study, indicating the development of a mild asthma phenotype, and this decrease was similar in non‐pregnant, singleton‐pregnant and twin‐pregnant ewes.
Eosinophil proportions in bronchoalveolar lavage and lung tissue were not affected by either asthma or pregnancy, nor was there evidence of lung airway remodelling in this cohort.
Our findings suggest that pregnancy does not increase asthma symptoms or severity of mild asthma