bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Validation of a Diagnostic Histopathological Scoring System for Capsular Contracture Based on 720 Breast Implant Capsules
Authors: Larsen Andreas , Timmermann Adam Mandrup , Kring Mikela , Mathisen Sif Birch , Bak Erik Eiler Frydshou , Weltz Tim Kongsmark , Ørholt Mathias , Vester-Glowinski Peter , Elberg Jens Jørgen , Trillingsgaard Jesper , Mielke Louise Vennegaard , Hölmich Lisbet Rosenkrantz , Damsgaard Tine Engberg , Roslind Anne , Herly Mikkel 
Published: February 2024

Abstract

Background
Capsular contracture is traditionally evaluated with the Baker classification, but this has notable limitations regarding reproducibility and objectivity.

Objectives
The aim of this study was to develop and validate procedure-specific histopathological scoring systems to assess capsular contracture severity.

Methods
Biopsies of breast implant capsules were used to develop histopathological scoring systems for patients following breast augmentation and breast reconstruction. Ten histological parameters were evaluated by multivariable logistic regression to identify those most associated with capsular contracture. Significant parameters (P &lt; .05) were selected for the scoring systems and assigned weighted scores (1-10). Validation was assessed from the area under the curve (AUC) and the mean absolute error (MAE).

Results
A total of 720 biopsies from 542 patients were included. Four parameters were selected for the augmentation scoring system, namely, collagen layer thickness, fiber organization, inflammatory infiltration, and calcification, providing a combined maximum score of 26. The AUC and MAE for the augmentation scoring system were 81% and 0.8%, which is considered strong. Three parameters were selected for the reconstruction scoring system, namely, fiber organization, collagen layer cellularity, and inflammatory infiltration, providing a combined maximum score of 19. The AUC and MAE of the reconstruction scoring system were 72% and 7.1%, which is considered good.

Conclusions
The new histopathological scoring systems provide an objective, reproducible, and accurate assessment of capsular contracture severity. We propose these novel scoring systems as a valuable tool for confirming capsular contracture diagnosis in the clinical setting, for research, and for implant manufacturers and insurance providers in need of a confirmed capsular contracture diagnosis.

Level of Evidence: 3
The ontogeny of social networks in wild great tits (Parus major)
Authors: Wild Sonja , Alarcón-Nieto Gustavo , Aplin Lucy M 
Published: February 2024

Abstract
Sociality impacts many biological processes and can be tightly linked to an individual’s fitness. To maximize the advantages of group living, many social animals prefer to associate with individuals that provide the most benefits, such as kin, familiar individuals, or those of similar phenotypes. Such social strategies are not necessarily stable over time but can vary with changing selection pressures. In particular, young individuals transitioning to independence should continuously adjust their social behavior in light of developmental changes. However, social strategies exhibited during adolescence in animals are understudied, and the factors underlying social network formation during ontogeny remain elusive. Here, we tracked associations of wild great tits (Parus major) during the transition to independence and across their first year of life. Both spatial and social factors predicted dyadic associations. During the transition to independence in spring, fledglings initially preferred to associate with siblings and peers over non-parent adults. We found no evidence for preferred associations among juveniles of similar age or fledge weight during that time but weak evidence for some potential inheritance of the parental social network. By autumn, after juveniles had reached full independence, they exhibited social strategies similar to those of adults by establishing stable social ties based on familiarity that persisted through winter into the next spring. Overall, this research demonstrates dynamic changes in social networks during ontogeny in a species with a fast life history and limited parental care, which likely reflect changes in selective pressures. It further highlights the importance of long-term social bonds based on familiarity in this species.
Difference-based covariance matrix estimation in time series nonparametric regression with application to specification tests
Authors: Bai Lujia , Wu Weichi 
Published: February 2024

Summary
Long-run covariance matrix estimation is the building block of time series inference. The corresponding difference-based estimator, which avoids detrending, has attracted considerable interest due to its robustness to both smooth and abrupt structural breaks and its competitive finite sample performance. However, existing methods mainly focus on estimators for the univariate process, while their direct and multivariate extensions for most linear models are asymptotically biased. We propose a novel difference-based and debiased long-run covariance matrix estimator for functional linear models with time-varying regression coefficients, allowing time series nonstationarity, long-range dependence, state heteroscedasticity and combinations thereof. We apply the new estimator to (i) the structural stability test, overcoming the notorious nonmonotonic power phenomena caused by piecewise smooth alternatives for regression coefficients, and (ii) the nonparametric residual-based tests for long memory, improving the performance via the residual-free formula of the proposed estimator. The effectiveness of the proposed method is justified theoretically and demonstrated by superior performance in simulation studies, while its usefulness is elaborated via real data analysis. Our method is implemented in the R package mlrv.
HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease
Authors: Yogeshwar Selina M , Muñiz-Castrillo Sergio , Sabater Lidia , Peris-Sempere Vicente , Mallajosyula Vamsee , Luo Guo , Yan Han , Yu Eric , Zhang Jing , Lin Ling , Fagundes Bueno Flavia , Ji Xuhuai , Picard Géraldine , Rogemond Véronique , Pinto Anne Laurie , Heidbreder Anna , Höftberger Romana , Graus Francesc , Dalmau Josep , Santamaria Joan , Iranzo Alex , Schreiner Bettina , Giannoccaro Maria Pia , Liguori Rocco , Shimohata Takayoshi , Kimura Akio , Ono Yoya , Binks Sophie , Mariotto Sara , Dinoto Alessandro , Bonello Michael , Hartmann Christian J , Tambasco Nicola , Nigro Pasquale , Prüss Harald , McKeon Andrew , Davis Mark M , Irani Sarosh R , Honnorat Jérôme , Gaig Carles , Finke Carsten , Mignot Emmanuel 
Published: February 2024

Abstract
Anti-IgLON5 disease is a rare and likely underdiagnosed subtype of autoimmune encephalitis. The disease displays a heterogeneous phenotype that includes sleep, movement and bulbar-associated dysfunction. The presence of IgLON5-antibodies in CSF/serum, together with a strong association with HLA-DRB1*10:01∼DQB1*05:01, supports an autoimmune basis.
In this study, a multicentric human leukocyte antigen (HLA) study of 87 anti-IgLON5 patients revealed a stronger association with HLA-DQ than HLA-DR. Specifically, we identified a predisposing rank-wise association with HLA-DQA1*01:05∼DQB1*05:01, HLA-DQA1*01:01∼DQB1*05:01 and HLA-DQA1*01:04∼DQB1*05:03 in 85% of patients. HLA sequences and binding cores for these three DQ heterodimers were similar, unlike those of linked DRB1 alleles, supporting a causal link to HLA-DQ. This association was further reflected in an increasingly later age of onset across each genotype group, with a delay of up to 11 years, while HLA-DQ-dosage dependent effects were also suggested by reduced risk in the presence of non-predisposing DQ1 alleles. The functional relevance of the observed HLA-DQ molecules was studied with competition binding assays. These proof-of-concept experiments revealed preferential binding of IgLON5 in a post-translationally modified, but not native, state to all three risk-associated HLA-DQ receptors. Further, a deamidated peptide from the Ig2-domain of IgLON5 activated T cells in two patients, compared with one control carrying HLA-DQA1*01:05∼DQB1*05:01.
Taken together, these data support a HLA-DQ-mediated T-cell response to IgLON5 as a potentially key step in the initiation of autoimmunity in this disease.
Dendrimer-induced synthesis of subnano materials and their characterization: establishing atom hybrid science
Authors: Kuzume Akiyoshi , Yamamoto Kimihisa 
Published: February 2024

Abstract
The precise molecular design of functional dendritic polymers enables the accumulation of multiple metals within a molecular cage. We have established a synthesizing methodology of metallodendrimers where the number of constituent atoms, the choice of elements, and the composition ratio were precisely controlled through an intramolecular Lewis acid-base interaction at each branch of phenylazomethine dendrons. Due to their inherent capsule effect, chemical reduction of metallodendrimers generates homogeneous subnanoparticles with a particle size of about 1 nm in diameter within the dendrimer cage. Fabricated subnanoparticles show amorphous crystal structures with distorted and fluctuated surface atoms and, with such a unique atomic structure, induce peculiar electronic states, surpassing unique and discrete physical and chemical properties of conventional nanoparticles and bulk metals. In this paper, we review the dendrimer-derived synthesis of atomic hybrid subnanoparticles and its research application established in our laboratory.
Matrix metalloproteinase-8 regulates dendritic cell tolerance in late polymicrobial sepsis via the nuclear factor kappa-B p65/β-catenin pathway
Authors: Lu Zhong-qiu , Zhang Chen , Zhao Lin-jun , Dong Wei , Lv Liang , Lu Yang , Chen Xiao-Yan , Zhang Jie , Liu Xin-yong , Xiao Zhong , Chen Long-wang , Yao Yong-ming , Zhao Guang-ju 
Published: February 2024

Abstract

Background
Tolerogenic dendritic cells (DCs) are associated with poor prognosis of sepsis. Matrix metalloproteinases (MMPs) have been shown to have immunomodulatory effects. However, whether MMPs are involved in the functional reprogramming of DCs is unknown. The study aims to investigate the role of MMPs in sepsis-induced DCs tolerance and the potential mechanisms.

Methods
A murine model of late sepsis was induced by cecal ligation and puncture (CLP). The expression levels of members of the MMP family were detected in sepsis-induced tolerogenic DCs by using microarray assessment. The potential roles and mechanisms underlying MMP8 in the differentiation, maturation and functional reprogramming of DCs during late sepsis were assessed both in vitro and in vivo.

Results
DCs from late septic mice expressed higher levels of MMP8, MMP9, MMP14, MMP19, MMP25 and MMP27, and MMP8 levels were the highest. MMP8 deficiency significantly alleviated sepsis-induced immune tolerance of DCs both in vivo and in vitro. Adoptive transfer of MMP8 knockdown post-septic bone marrow-derived DCs protected mice against sepsis-associated lethality and organ dysfunction, inhibited regulatory T-cell expansion and enhanced Th1 response. Furthermore, the effect of MMP8 on DC tolerance was found to be associated with the nuclear factor kappa-B p65/β-catenin pathway.

Conclusions
Increased MMP8 levels in septic DCs might serve as a negative feedback loop, thereby suppressing the proinflammatory response and inducing DC tolerance.
The endless expansion of carbon offsetting: sequestration by agricultural soils in historical perspective
Authors: Berta Nathalie , Roux Alain 
Published: February 2024

Abstract
The growing popularity of the idea of carbon budgets has contributed to a reshaping of climate policy goals in terms of carbon neutrality (net zero emissions) instead of strict emissions reductions. As a consequence, new legitimacy has been given to debatable efforts to use negative emissions for offsetting purposes. In this respect, sequestration by agricultural soils is now presented as a promising way to offset fossil carbon emissions. Adopting a historical perspective, this article studies the way soil sciences and economics amplified the political promise of agricultural sequestration, despite enduring concerns about its non-permanence and reversibility. First, it shows how, from the 1980s, the soil sciences conveyed a mechanical representation of soil as a carbon sink, and on this basis worked to assess its sequestration potential. Second, it shows how agricultural economics helped to translate this physical potential into economic opportunity, extolling its low cost relative to decarbonisation options. Both tendencies contributed to the institutionalisation of a new equivalence between the reduction of CO2 emissions and organic carbon sequestration through the enlargement of the international system of carbon accounting, and both encouraged the development of soil-based offsets, at the cost of environmental integrity.
Growing concerns about using hypoxia-inducible factor prolyl hydroxylase inhibitors for the treatment of renal anemia
Authors: Nakanishi Takeshi , Kuragano Takahiro 
Published: February 2024

ABSTRACT
Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) have emerged as a novel therapeutic class for treating anemia in patients with chronic kidney disease. Small molecule analogs of α-ketoglutarate (AKG), an essential substrate for 2-oxoglutarate-dependent dioxygenases (2-OGDDs), including prolyl hydroxylase domain proteins (PHDs), inhibit PHDs pharmacologically and thereby prevent HIF degradation. HIF stabilization alleviates anemia through several stimulatory effects on erythropoiesis, but it also affects the expression of many anemia-unrelated genes whose protein products exert important functions in vivo. Therefore, the pleiotropic effects of HIF stabilization under normoxic conditions deserve to be examined in more detail. Specifically, we believe that particular attention should be given to epigenetic modifications among the various AKG-based metabolic systems that may be altered by HIF-PHIs. It is noteworthy that AKG has been reported to exert health-protective actions. AKG-based metabolic systems include enzymes associated with the tricarboxylic acid cycle and amino acid metabolism, as well as 2-OGDD-mediated processes, which play important roles in many biological reactions. In this review, we examine the multifaceted effects of HIF-PHIs, encompassing not only their on-target effect of HIF stabilization but also their off-target inhibitory effects on various AKG-based metabolic systems. Furthermore, we examine its potential relevance to cardiovascular complications, based on clinical and animal studies suggesting its involvement in vascular calcification, thrombogenesis and heart failure. In conclusion, although HIF-PHIs offer a promising avenue for anemia treatment in CKD patients, their broader impact on multiple biological systems raises substantial concerns. The intricate interplay between HIF stabilization, AKG competition and cardiovascular complications warrants extensive, long-term investigations to ensure the safety and usefulness of HIF-PHIs in clinical practice.
Family-Centered Early Intervention Deaf/Hard of Hearing (FCEI-DHH): Methods
Authors: Moodie Sheila T F , Moeller Mary Pat , Szarkowski Amy , Gale Elaine , Smith Trudy , Birdsey Bianca C , Carr Gwen , Stredler-Brown Arlene , Yoshinaga-Itano Christine , Holzinger Daniel 
Published: February 2024

Abstract
This is the fourth article in a series of eight that comprise a special issue on family-centered early intervention (FCEI) for children who are deaf or hard of hearing (DHH) and their families, FCEI-DHH. This article describes the co-production team and the consensus review method used to direct the creation of the 10 Principles described in this special issue. Co-production is increasingly being used to produce evidence that is useful, usable, and used. A draft set of 10 Principles for FCEI-DHH and associated Tables of recommended behaviors were developed using the knowledge creation process. Principles were refined through two rounds of eDelphi review. Results for each round were analyzed using measures of overall group agreement and measures that indicated the extent to which the group members agreed with each other. After Round 2, with strong agreement and low to moderate variation in extent of agreement, consensus was obtained for the 10 Principles for FCEI-DHH presented in this special issue. This work can be used to enhance evolution of FCEI-DHH program/services and systems world-wide and adds to knowledge in improvement science.
Family-Centered Early Intervention Deaf/Hard of Hearing (FCEI-DHH): Introduction
Authors: Moeller Mary Pat , Gale Elaine , Szarkowski Amy , Smith Trudy , Birdsey Bianca C , Moodie Sheila T F , Carr Gwen , Stredler-Brown Arlene , Yoshinaga-Itano Christine ,   FCEI-DHH International Consensus Panel, Berke Michele , Binder Doris , Carr Gwen , Cloete Natasha , Crace Jodee , Crowe Kathryn , Dauer Frank , DesGeorges Janet , Dirks Evelien , Fellinger Johannes , Ferguson Bridget , Grover Anita , Hofer Johannes , Holten Sonja Myhre , Holzinger Daniel , Hopkins Karen , Laugen Nina Jakhelln , Lillo-Martin Diane , Magongwa Lucas , Martin Amber , McCall Jolanta , McCarthy Melissa , McDonnell Teresa , Movallali Guita , Müllegger-Treciokaite Daiva , Olson Stephanie B , Olusanya Bolajoko O , Pittman Paula , Porter Ann , Russell Jane , Sarkar Snigdha , Seaver Leeanne , Storbeck Claudine , Stredler-Brown Arlene , Thompson Nanette , Windisch Sabine , Yoshinaga-Itano Christine , Young Alys , Zheng Xuan , Holzinger Daniel 
Published: February 2024

Abstract
This article is the first of eight articles in this special issue on Family-Centered Early Intervention (FCEI) for children who are deaf or hard of hearing (DHH), or FCEI-DHH. In 2013, a diverse panel of experts published an international consensus statement on evidence-based Principles guiding FCEI-DHH. Those original Principles have been revised through a coproduction process involving multidisciplinary collaborators and an international consensus panel, utilizing the best available evidence and current understanding of how to optimally support children who are DHH and their families. This revision (referred to as expanded Principles) was motivated by the need to incorporate (a) input from family leaders and DHH leaders, (b) broader international and cultural perspectives, (c) new empirical evidence, and (d) research in human development. This Introduction provides an overview of the rationale, purposes, and main content areas to be addressed throughout the special issue.
Family-Centered Early Intervention Deaf/Hard of Hearing (FCEI-DHH): Foundation Principles
Authors: Moeller Mary Pat , Gale Elaine , Szarkowski Amy , Smith Trudy , Birdsey Bianca C , Moodie Sheila T F , Carr Gwen , Stredler-Brown Arlene , Yoshinaga-Itano Christine ,   FCEI-DHH International Consensus Panel, Berke Michele , Binder Doris , Carr Gwen , Cloete Natasha , Crace Jodee , Crowe Kathryn , Dauer Frank , DesGeorges Janet , Dirks Evelien , Fellinger Johannes , Ferguson Bridget , Grover Anita , Hofer Johannes , Holten Sonja Myhre , Holzinger Daniel , Hopkins Karen , Laugen Nina Jakhelln , Lillo-Martin Diane , Magongwa Lucas , Martin Amber , McCall Jolanta , McCarthy Melissa , McDonnell Teresa , Movallali Guita , Müllegger-Treciokaite Daiva , Olson Stephanie B , Olusanya Bolajoko O , Pittman Paula , Porter Ann , Russell Jane , Sarkar Snigdha , Seaver Leeanne , Storbeck Claudine , Stredler-Brown Arlene , Thompson Nanette , Windisch Sabine , Yoshinaga-Itano Christine , Young Alys , Zheng Xuan , Holzinger Daniel 
Published: February 2024

Abstract
This article is the fifth in a series of eight articles that comprise a special issue on Family-Centered Early Intervention (FCEI) for children who are deaf or hard of hearing (DHH) and their families, or FCEI-DHH. The 10 FCEI-DHH Principles are organized conceptually into three sections (a) Foundation Principles, (b) Support Principles, and (c) Structure Principles. Collectively, they describe the essential Principles that guide FCEI for children who are DHH and their families. This article describes the Foundation Principles (Principles 1 and Principle 2). The Foundation Principles emphasize the essential elements of ensuring that families with children who are DHH can access early intervention (EI) and other appropriate supports, as well as highlight the need for provision of EI that is family-centered. Implementation of these FCEI-DHH Principles is intended to improve the lives and the outcomes of children who are DHH and their families around the globe.
European Association of Cardio-Thoracic Surgery (EACTS) expert consensus statement on perioperative myocardial infarction after cardiac surgery
Authors: Gaudino Mario , Flather Marcus , Capodanno Davide , Milojevic Milan , Bhatt Deepak L , Biondi Zoccai Giuseppe , Boden William E , Devereaux P J , Doenst Torsten , Farkouh Michael , Freemantle Nicholas , Fremes Stephen , Puskas John , Landoni Giovanni , Lawton Jennifer , Myers Patrick O , Redfors Björn , Sandner Sigrid 
Published: February 2024

Abstract
Cardiac surgery may lead to myocardial damage and release of cardiac biomarkers through various mechanisms such as cardiac manipulation, systemic inflammation, myocardial hypoxia, cardioplegic arrest and ischaemia caused by coronary or graft occlusion. Defining perioperative myocardial infarction (PMI) after cardiac surgery presents challenges, and the association between the current PMI definitions and postoperative outcomes remains uncertain. To address these challenges, the European Association of Cardio-Thoracic Surgery (EACTS) facilitated collaboration among a multidisciplinary group to evaluate the existing evidence on the mechanisms, diagnosis and prognostic implications of PMI after cardiac surgery. The review found that the postoperative troponin value thresholds associated with an increased risk of mortality are markedly higher than those proposed by all the current definitions of PMI. Additionally, it was found that large postoperative increases in cardiac biomarkers are prognostically relevant even in absence of additional supportive signs of ischaemia. A new algorithm for PMI detection after cardiac surgery was also proposed, and a consensus was reached within the group that establishing a prognostically relevant definition of PMI is critically needed in the cardiovascular field and that PMI should be included in the primary composite outcome of coronary intervention trials.