bluuebunny/crossref_metadata_2025_split huggingface dataset:
Far-red and sensitive sensor for monitoring real time H2O2 dynamics with subcellular resolution and in multi-parametric imaging applications.
Authors: Berndt Andre , Lee Justin , Nguyen Amanda , Jin Zheyu , Moghadasi Aida , Gibbs Chelsea , Wait Sarah , Evitts Kira , Asencio Anthony , Bremner Samantha , Zuniga Shani , Chavan Vedant , Williams Andy , Smith Annette , Moussavi-Harami Farid , Regnier Michael , Young Jessica , Mack David , Nance Elizabeth , Boyle Patrick 
Published: April 2024

Abstract
H2O2 is a key oxidant in mammalian biology and a pleiotropic signaling molecule at the physiological level, and its excessive accumulation in conjunction with decreased cellular reduction capacity is often found to be a common pathological marker. Here, we present a red fluorescent Genetically Encoded H2O2 Indicator (GEHI) allowing versatile optogenetic dissection of redox biology. Our new GEHI, oROS-HT, is a chemigenetic sensor utilizing a HaloTag and Janelia Fluor (JF) rhodamine dye as fluorescent reporters. We developed oROS-HT through a structure-guided approach aided by classic protein structures and recent protein structure prediction tools. Optimized with JF635, oROS-HT is a sensor with 635 nm excitation and 650 nm emission peaks, allowing it to retain its brightness while monitoring intracellular H2O2 dynamics. Furthermore, it enables multi-color imaging in combination with blue-green fluorescent sensors for orthogonal analytes and low auto-fluorescence interference in biological tissues. Other advantages of oROS-HT over alternative GEHIs are its fast kinetics, oxygen-independent maturation, low pH sensitivity, lack of photo-artifact, and lack of intracellular aggregation. Here, we demonstrated efficient subcellular targeting and how oROS-HT can map inter and intracellular H2O2 diffusion at subcellular resolution. Lastly, we used oROS-HT with other green fluorescence reporters to investigate the transient effect of the anti-inflammatory agent auranofin on cellular redox physiology and calcium levels via multi-parametric, dual-color imaging.
What do we study when studying politics anddemocracy?A thematic analysis of how politics and democracy aretreated in SIGCHI conference papers
Authors: Nelimarkka Matti , Vuorenmaa Ville 
Published: April 2024

Abstract
Human–computer interaction scholars are increasingly touching on topics relatedto politics or democracy. As these concepts are ambiguous, an examination ofconcepts’ invoked meanings aids in the self-reflection of our research efforts. Weconduct a thematic analysis of all papers with the word ‘politics’ in abstract,title or keywords (n=378) and likewise 152 papers with the word ‘democracy.’We observe that these words are increasingly being used in human-computerinteraction, both in absolute and relative terms. At the same time, we show thatresearchers invoke these words with diverse levels of analysis in mind: the earlyresearch focused on mezzo-level (i.e., small groups), but more recently the workhas begun to include macro-level analysis (i.e., society and politics as played inthe public sphere). After the increasing focus on the macro-level, we see a tran-sition towards more normative and activist research, in some areas it replacesobservational and empirical research. These differences indicate semantic differ-ences, which – in the worst case – may limit scientific progress. We bring thesedifferences visible to help in further exchanges of ideas and human–computerinteraction community to explore how it orients itself to politics and democracy.
Study of fluid turbulence characteristics and structural evolution in a reciprocating mixing tank
Authors: Wang Li , Wang Shibo , Zhai Yuling , Xu Jianxin , xiao qingtai 
Published: April 2024

Abstract

Reciprocating mixing is a novel mixing technique designed to enhance mixing efficiency. In this method, the mixing paddle moves back and forth along the axial direction periodically, unlike conventional mixing methods. The mixing efficiency of reciprocating stirring can be significantly enhanced compared to conventional stirring. In this thesis, the flow field characteristics and numerical simulation of the Rushton pulp reciprocating mixing tank are analyzed using the Computational Fluid Dynamics (CFD) method with VOF and UDF function control. It has been found that reciprocating mixing increases the overall speed of the fluid by about 8%, the turbulent kinetic energy by 35%-45%, and the turbulent kinetic energy dissipation rate by 10%-16% compared with conventional mixing. Reciprocating mixing significantly affects the tank basin, enhancing the axial flow of the fluid in the tank, disrupting the circulating structure of conventional agitation, and dynamically integrating the multiple flow regions of conventional agitation to improve mixing homogeneity. Additionally, the evolution process of vortex generation, development, and extinction by reciprocal stirring is quantitatively analyzed to determine the optimal size of paddle discs under different conditions. The maximum values of turbulent kinetic energy in the two stirring modes are FS-4/12D and RS-5/12D, respectively. The reason for the abrupt decrease of turbulent kinetic energy in RS-4/12D is explained as follows: The uncaused quadratic flow variance indicates that the reduction of the tail vortex size can effectively destroy the reflux zone, thus reducing the energy consumption at the tail vortex and allowing more energy to be used for fluid mixing. The results of this paper provide a theoretical basis and reference data for the engineering application of reciprocating mixing.
Does abusive supervision increase employees’ helping behavior? An exploration of mediating and moderating mechanisms
Authors: Nasab Roghayeh Hekmat , biuki Nahid Amrollahi , Sharifirad Mohammad Sadegh , Ardakani Mohammad Shaker 
Published: April 2024

Abstract

Background: Typically, researchers believe that abusive supervision decreases employees' helping behavior. However, according to the emotional process theory of abusive supervision, subordinates show more helping behavior under certain conditions. The purpose of this study was to examine the impact of abusive supervision on employees' helping behavior, with a focus on the mediating role of self-blame and guilt as well as the moderating effects of core self-evaluation (CSE) and power distance.
Methods: In this study, the PROCESS Macro model was used to deeply investigate the proposed moderated mediation model. Confirmatory factor analysis was performed with AMOS. The employees of various private and state service-offering organizations in Yazd, Iran, were invited to participate in the study (n = 381). They were selected through simple random sampling. The data were collected with the Abusive Supervision Scale [1], State Shame and Guilt Scale (SSGS), Self-blame Questionnaire [3], Core Self-Evaluation Scale [4], and Power Distance Scale developed by Dorfman and Howell [5]. The scale developed by Dalal et al. [2] was also used to rate the employees’ helping behavior. The hypothesized model was analyzed according to the PROCESS Macro model.
Results: The direct association between abusive supervision and employees’ helping behavior was significantly negative. The mediation by self-blame and guilt was negative too. The relationship between abusive supervision and self-blame was positively correlated to core self-evaluation (CSE), while the association between self-blame and guilt was negatively correlated to power distance.
Conclusion: In the context of abusive supervision and its aftermath, this study introduced self-blame and guilt as two mediators that can influence subordinates’ reactions to abusive supervision. Also, for the first time, CSE was tested as a moderator between abusive supervision and self-blame. Finally, in response to previous calls for research [6,7], the moderating role of subordinates’ power distance orientation in the relationship between self-blame and guilt was investigated.
Static magnetic order with strong quantum fluctuations in spin-1/2 honeycomb magnet Na2Co2TeO6
Authors: Ma Jie , Jiao Jinlong , Li Xiyang , Lin Gaoting , Shu Mingfang , Zaharko Oksana , Shiroka Toni , Hong Tao , Kolesnikov Alexander , Deng Guochu , Dunsiger Sarah , Aronson Meigan , Zhou Haidong , Wang Xiaoqun , Shang Tian 
Published: April 2024

Abstract

Kitaev interactions, arising from the interplay of frustration and bond anisotropy, can lead to strong quantum fluctuations and, in an ideal case, to a quantum-spin-liquid state. However, in many nonideal materials, spurious non-Kitaev interactions typically promote a zigzag antiferromagnetic order in the d-orbital transition metal compounds. Combining neutron scattering with muon-spin rotation and relaxation techniques, we provide new insights into the exotic properties of Na2Co2TeO6, a candidate material of the Kitaev model. Below TN, the zero-field muon-spin relaxation rate becomes almost constant (at 0.45 ms-1). We attribute this temperature-independent muon-spin relaxation rate to the strong quantum fluctuations, as well as to the frustrated Kitaev interactions. As the magnetic field increases, neutron scattering data indicate a broader spin-wave-excitation at the K-point. Therefore, quantum fluctuations seem not only robust but are even enhanced by the applied magnetic field. Our findings provide valuable hints for understanding the onset of the quantum-spin-liquid state in Kitaev materials.
Contour-Assistance-Based Video Matting Localization
Authors: zhu wenyi , Ding Xiangling , Zhao Yulin , Deng Yinqian 
Published: April 2024

Abstract

Video matting is developed to replace the foreground object in video frames by forecasting their alpha matte, which was originally used in film special effects production, advertisement production, and live streaming. However , it can be used as a malicious tampering operation, and hence its passive forensics is especially important as the key foundation of judicial forensics. A key challenge in the current detection of video matting tampering is how to locate the complete tampered region without generating false alarms, not only that tampering detection of video needs to take into account the temporal dimension, but successive frames need to be analyzed to detect forged video regions. In this paper, a dual-branch network is constructed by integrating the object contour information to capture rich tampering traces and contour features, which are introduced by focusing on the information of the entire video sequence. In addition, a manipulation contour detection module and a feature enhancement module are integrated to identify tampering regions better. Extensive experimental results on publicly manipulated and synthetic manipulated datasets show that the proposed method can accurately locate tampered regions and outperform state-of-the-art video matting forensic methods.
Peer effects on older adults' preferences for formal long-term care in China
Authors: Zhang Anqi , Liu Jin , Maitland Elizabeth , Leng Anli , Nicholas Stephen , Wang Mengyao 
Published: April 2024

Abstract
Objective
To examine the impact of the peer effects on the preferences of the older-aged Chinese for formal long-term care (LTC) services.
Methods
During July-August 2022, the study conducted a randomized controlled experiment using a survey design. Respondents aged 50–70, were randomly assigned to a control group and a peer effect group, where the peer group was divided into Peer 1 not having friends and relatives receiving LTC and Peer 2 having relatives and friends receiving LTC. Data included personal socioeconomic-demographic information, LTC service needs, and willingness to accept formal LTC. Statistical analysis was performed using descriptive statistics, logistic regressions, and heterogeneity analysis.
Results
Compared to the control group, the peer effect groups showed a statistically significant increase of 20.06% in the proportion of elderly individuals opting for formal LTC. The study found that willingness to accept formal long-term care services increased with the peer effect intervention, and Peer 2, with family and friends receiving LTC, had a larger uptake of LTC than Peer 1 with no family and friends receiving LTC. Statistical analysis confirmed significant differences between the control, Peer 1 and Peer 2 groups. In terms of peer effects interventions, older people with high incomes and unsure about their future risks of developing a chronic disease were more likely to opt for formal LTC. Heterogeneity analysis of the peer effects group revealed that sex, age, marital status, residential location, educational level, monthly income, number of children, presence of chronic diseases, and risk of chronic diseases, significantly influenced the willingness to accept LTC services within the two peer groups.
Conclusion
The findings suggest that peer effects played a critical role in shaping the preferences of older aged Chinese for formal LTC services. The study highlights the need for strategies to utilize peer influences, as well as socioeconomic and demographic factors, in policy-making and communicating strategies to enhance acceptance of LTC services among China’s older-aged population. Tailored interventions and information dissemination that leverage peer networks and address varied socioeconomic-demographic needs are crucial for effective LTC policy and service implementation.
Application of Dynamic [18F]-FDG PET/CT Multiparametric Imaging Leads to an Improved Differentiation of Benign and Malignant Lung Lesions
Authors: Zhao Yihan , Lv Tao , Xu Yue , Yin Jiankang , Wang Xin , Xue Yangyang , Zhu Gan , Yu Wenjing , Wang Hui , Li Xiaohu 
Published: April 2024

Abstract

Purpose
To evaluate the potential of whole-body dynamic (WBD) 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography ([18F]-FDG PET/CT) multiparametric imaging in the differential diagnosis between benign and malignant lung lesions.
Procedures
We retrospectively analyzed WBD PET/CT scans from patients with lung lesions performed between April 2020 and March 2023. Multiparametric images including standardized uptake value (SUV), metabolic rate (MRFDG) and distribution volume (DVFDG) were visually interpreted and compared. We adopted SUVmax, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) for semi-quantitative analysis, MRmax and DVmax values for quantitative analysis. We also collected the patients’ clinical characteristics. The variables above with P-value < 0.05 in the univariate analysis were entered into a multivariate logistic regression. The statistically significant metrics were plotted on receiver-operating characteristic (ROC) curves.
Results
A total of 60 patients were included for data evaluation. We found that most malignant lesions showed high uptake on MRFDG and SUV images, and low or absent uptake on DVFDG images, while benign lesions showed low uptake on MRFDG images and high uptake on DVFDG images. Most malignant lesions showed a characteristic pattern of gradually increasing FDG uptake, whereas benign lesions presented an initial rise with rapid fall, then kept stable at a low level. The AUC values of MRmax and SUVmax are 0.874 (95% CI: 0.763–0.946) and 0.792 (95% CI: 0.667–0.886), respectively. DeLong’s test showed the difference between the areas is statistically significant (P < 0.001).
Conclusions
Our study demonstrated that dynamic [18F]-FDG PET/CT imaging based on the Patlak analysis was a more accurate method of distinguishing malignancies from benign lesions than conventional static PET/CT scans.
First Observation of Splenic Infarction attributed to Infective Endocarditis in Pregnant Women with a History of MVR: A Case Report
Authors: Cao Benben , Shi Mingxing , Li Yang 
Published: April 2024

Abstract
Background: Infective endocarditis (IE) is a rare disease that occurs during pregnancy. The incidence of embolic complications associated with IE is high, reaching up to 50%, with spleen being the most commonly affected organ at 32.8%. Despite this, there is a significant global lack of reports on splenic infarction (SI) resulting from IE during pregnancy.
Case presentation: A 33-year-old pregnant woman was admitted to our hospital at 29 3/7 weeks' gestation, presenting with symptoms of hyperpyrexia, abdominal pain, and diarrhea. She had undergone mechanical MVR due to rheumatic heart disease and had been on warfarin therapy for a duration of nine years. Our initial diagnosis was gastroenteritis. During her hospitalization, she experienced mild and persistent left upper quadrant abdominal pain. Abdominal ultrasound suggested a potential splenic infarction. However, transthoracic echocardiography and transesophageal echocardiography confirmed normal mechanical valve function without any vegetation findings. We administered anti-inflammatory and anti-coagulation treatments. The patient unexpectedly terminated the pregnancy via cesarean section due to PROM. Warfarin was retained prior to the surgery and resumed post-surgery. Additionally, therapy with IH low-molecular-weight heparin was administered, a strategy known as bridging strategy.
Conclusion: Pregnant women with a history of MVR can develop IE. Although the occurrence is rare, these individuals are at potential risk for splenic infarction when undergoing anticoagulant therapy. The management approach during pregnancy requires a collaborative effort from multidisciplinary team and must be tailored to the individual patient.
Right Ventricular Dysfunction, the new Face of Long COVID-19, Assessed by Speckle-Tracking Echocardiography; a cross-sectional study
Authors: Abtahi Firoozeh , Ayoobikashkooli Yasin , Mohammadian Seyedeh Fatemeh , Hassani Amir Hossein 
Published: April 2024

Abstract
Purpose: after the COVID-19 pandemic has been resolved, the world is encountered with long-term effects of this disease that is now called long-COVID-19. In this study, we aimed to assess the effects of previous severe COVID-19 on right ventricular (RV) function.
Methods and Materials: in this study, previously healthy patients who were admitted in intensive care units due to COVID-19 in a one-year period were evaluated using speckle-tracking echocardiography after one year of their resolution. The echocardiographic parameters of the RV were reported and assessed based on the COVID-19 treatment and baseline condition of the patients.
Results: Eighty-two patients with a mean age of 46.54±12.098 years old entered the study of whom 46 (56.1%) were male. Based on RV free wall longitudinal strain, RV global longitudinal strain, and RV fractional area change 8 (9.8%), 10 (12.2%), and 10 (12.2%) patients had RV dysfunction in a period of at least six months following their discharge. Nevertheless, 33.3% of the patients had at least one determinant of RV dysfunction. We found that the patients who needed anticoagulants and vasopressors were more likely to develop RV dysfunction. Also, the patients’ condition, especially respiratory rate on admission was a better predictor of future RV dysfunction compared to lab data.
Conclusion: COVID-19 can induce subclinical and clinical RV dysfunction persisting for as long as a year after the resolution of infection. Since this abnormality can increase cardiovascular mortality, screening of patients who had been hospitalized due to COVID-19 for RV dysfunction might not be unreasonable.
GhVIM28, a negative regulator identified from VIM family genes to depredate protein systematically in cotton under salt stress
Authors: Yang Zhining , Lu Xuke , Wang Ning , Mei Zhengding , Fan Yapeng , Zhang Menghao , Wang Lidong , Sun Yuping , Chen Xiao , Huang Hui , Meng Yuan , Liu Mengyue , Han Mingge , Chen Wenhua , Zhang Xinrui , Yu Xin , Chen Xiugui , Wang Shuai , Wang Junjuan , Zhao Lanjie , Guo Lixue , Peng Fanjia , Feng Keyun , Gao Wenwei , Ye Wuwei 
Published: April 2024

Abstract
The VIM gene family plays a vital role in the growth, development, and stress responses of plants, while the molecular mechanism of VIM genes in responding to salt stress is remain unclear. This study analyzed the phylogenetic relationships, chromosomal localization, conserved motifs, gene structure, cis-acting elements, and gene expression patterns of the VIM gene family in four cotton varieties. A total of 29, 29, 17, and 14 members were identified in Gossypium hirsutum (G.hirsutum), Gossypium barbadense(G.barbadense), Gossypium arboreum (G.arboreum), and Gossypium raimondii (G. raimondii), respectively. Chromosomal localization indicated the maturity and evolution of this gene family. Analysis of gene structure and conserved motifs revealed a conserved pattern among GhVIMs genes. Furthermore, cis-acting element analysis demonstrated the presence of stress-responsive elements, hormone-responsive elements, and growth-related elements in the promoter region of GhVIMs genes, highlighting their significant role in plant growth and stress response. Additionally, gene expression analysis revealed different expression patterns and tissue specificity of GhVIMs genes under abiotic stress. To better understand the functional role of GhVIM28, GhVIM28 gene was silenced using virus-induced gene silencing, and the results indicated that GhVIM28 acts as a salt-tolerant negative regulator.
First Time Morphological and Molecular Isolation of Epicoccum sorghinum Pathogenicity in the Cassava Brown Leaf Spot Disease in Kenya
Authors: Onyango Ephine Awuor , Kituyi Sarah Naulikha , Hunja Carol Wangui , Kimatu Josphert Ngui , Nyaboga Evans Nyaega 
Published: April 2024

Abstract

Cassava brown leaf spot (BLS) is among the most damaging diseases that significantly reduce cassava root yields. There has been need to find varieties resistant or tolerant to BLS. Hence, in this study drought-resistant cassava varieties were being agronomically screened in an experimental farm in Kitui County-Kenya. One variety in the plots, commonly referred to as Kasukari, was found to exhibit abnormal morphological aberrations whose cause necessitated systematic studies. Morphological, microscopic and DNA molecular identification techniques were applied on the isolates to identify the causal agent(s). 162 samples of the Kasukari variety were used to determine the prevalence and severity of the disease, while 15 samples were used to determine effects of the disease in the plots. The prevalence within the plots had no significant difference (ꭓ2 = 6, p-value = 0.1991). However, there was significant difference in the severity (ꭓ2 = 53.013, p-value = 1.166e-09). Pathogenicity tests of ten isolates were conducted in vitro whereby the spore suspension was made from each isolate and inoculated in detached fresh Kasukari variety leaves. Polymerase chain reaction performed by the universal primer, internal transcribed spacer (ITS) marker identified Alternaria sp, Epiccocum sp, Preussia sp, and Cladosporium sp. However, it was the Epiccocum sp that was reisolated from the reinfected Kasukari Cassava variety and hence confirmed as the main causal agent. Mycological keys found this fungus to be Epicoccum sorghinum. This is the first time for E. sorghinum to be associated with BLS in Kenya. Morphologically, the disease distorted leaves and reduced root quality. This infection necessitates further enriching and screening of the cassava genome for more resistant and tolerant varieties especially in light of the climate change phenomenon.