bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benzophenanthridine Alkaloids from Zanthoxylum nitidum (Roxb.) DC, and Their Analgesic and Antiinflammatory Activities.
Authors: Hu Jiang , Zhang Wei‐Dong , Liu Run‐Hui , Zhang Chuan , Shen Yun‐Heng , Li Hui‐Liang , Liang Ming‐Jin , Xu Xi‐Ke 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Isolation of Four New Pterocarpans from Zygophyllum eurypterum (Syn. Z. atriplicoides) with Enzyme‐Inhibition Properties.
Authors: Ahmad Viqar Uddin , et al. et al. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis, DNA Binding and Cytotoxicity of New Pyrazole Emodin Derivatives.
Authors: Tan J.‐H. , Zhang Q.‐X. , Huang Z.‐S. , Chen Y. , Wang X.‐D. , Gu L.‐Q. , Wu J. Y. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Vialinin B, a Novel Potent Inhibitor of TNF‐α Production, Isolated from an Edible Mushroom, Thelephora vialis.
Authors: Xie Chun , Koshino Hiroyuki , Esumi Yasuaki , Onose Jun‐ichi , Yoshikawa Kunie , Abe Naoki 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Single‐Crystal Nanotubes of II3‐V2 Semiconductors.
Authors: Shen Guozhen , Bando Yoshio , Ye Changhui , Yuan Xiaoli , Sekiguchi Takashi , Golberg Dmitri 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Vapor‐Liquid‐Solid Mechanisms: Challenges for Nanosized Quantum Cluster/Dot/Wire Materials
Authors: Cheyssac P. , Sacilotti M. , Patriarche G. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Diterpenoids from Isodon Species and Their Biological Activities
Authors: Sun Han‐Dong , Huang Sheng‐Xiong , Han Quan‐Bin 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Small Molecule Microarrays: Applications Using Specially Tagged Chemical Libraries
Authors: Wang Jun , Uttamchandani Mahesh , Sun Hongyan , Yao Shao Q. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ester Derivatives of Nucleoside Inhibitors of Reverse Transcriptase. Part 2. Molecular Systems for the Combined Therapy with 3′‐Azido‐3′‐deoxythymidine and 2′,3′‐Didehydro‐3′‐deoxythymidine
Authors: Berezovskaya Yu. V. , Chudinov M. V. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Multicomponent Reactions with 1,3‐Dicarbonyl Derivatives: Applications to the Synthesis of Polyfunctionalized Heterocycles
Authors: Constantieux Thierry , Rodriguez Jean 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
UVB‐Induced Skin Damage and the Protection/Treatment — Effects of a Novel, Hydrophilic γ‐Tocopherol Derivative
Authors: Kobayashi Shizuko 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hexafluoroacetone as Protecting and Activating Reagent: New Routes to Amino, Hydroxy, and Mercapto Acids and Their Application for Peptide and Glyco‐ and Depsipeptide Modification
Authors: Spengler Jan , Boettcher Christoph , Albericio Fernando , Burger Klaus 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Kinetics of Radionuclides and Heavy Metals Behaviour in Soils: Implications for Plant Growth
Authors: Igwe J. C. , Nnorom I. C. , Gbaruko B. C. 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Mechanism of the Hydroxycarbonylation of 1‐Hexene Catalyzed by Immobilized Rhodium Complexes of Pyridine Ligands
Authors: Pardey Alvaro J. , Hung‐Low Fernando , Uzcategui Gabriela C. , Ortega Marisol C. , Longo Clementina 
Published: January 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Computational identification and analysis of G protein‐coupled receptor targets
Authors: Lu Feng , Li Jin , Jiang Zhenran 
Published: January 2007

AbstractThe completion of the human genome sequence has provided a large pool of potential drug targets for disease therapy. G protein–coupled receptors (GPCRs), which are central to signaling networks that regulate basic cellular processes, represent the most important known class of therapeutic targets for multiple disease states. Bioinformatics approaches can be applied to facilitate the identification of novel GPCRs, understanding their physiological and pathological roles, and screening for drug discovery. The present review summarizes current bioinformatics approaches that can be used to identify and analyze GPCR targets. In addition, the limitations of these technologies with the intention of setting reasonable expectations are also discussed together with some potential avenues for GPCR research. Drug Dev. Res. 67:771–780, 2006. © 2007 Wiley‐Liss, Inc.
Monoclonal antibodies: a morphing landscape for therapeutics
Authors: Nicolaides Nicholas C. , Sass Philip M. , Grasso Luigi 
Published: January 2007

AbstractThe concept of using antibodies as therapeutics to cure human diseases was postulated nearly 100 years ago by Paul Ehrlich and subsequently enabled by the discovery of hybridoma technology by Kohler and Milstein in 1975. While the use of monoclonal antibodies (mAbs) as drugs that can specifically target a disease‐associated antigen is compelling, it has taken a quarter century for these molecules to be adopted as bona fide therapeutic agents. Despite their slow pursuit in drug development during the pioneering years, it is now estimated that there are nearly 500 mAb‐based therapies in development. Major factors that have influenced the acceptance of monoclonal antibodies as therapeutics include their drug safety profiles, technological advancements for facilitating mAb discovery and development, and market success. Early on, it was demonstrated that antibodies could elicit clinical benefit by antagonizing a specific antigen without the common side effects that are prevalent with small chemical entities due to their nonspecific effects on homeostatic biochemical pathways. In addition, the significant technological advances that the biotechnology industry has established for developing and producing monoclonal antibodies at commercial scale in a more efficient and cost‐effective manner has broadly enabled their use as therapeutics. However, despite the beneficial pharmacologic advantages and technological advances, it has been the sheer market success that monoclonal antibody products have achieved over the past few years that has propelled their vast pursuit by the biopharmaceutical industry in light of their value‐creating potential. Here we provide an overview of the monoclonal antibody industry and discuss evolving technologies and strategies that are being pursued to overcome challenges in the changing marketplace. Drug Dev. Res. 67:781–789, 2006. © 2007 Wiley‐Liss, Inc.
Targeting the p53 tumor suppressor gene function in glioblastomas using small chemical molecules
Authors: Magrini Roberta , Bakker Annette , Gaviraghi Giovanni , Terstappen Georg C. 
Published: January 2007

AbstractGlioblastoma multiforme (GBM) is recognized as the most frequent and malignant glioma of which two genetically different subtypes can be distinguished. Primary, de novo glioblastomas show a p53 wild type (wt) status and in 10% of the cases hdm2 overexpression/amplifications occur. In these tumors, the inactivation of the tumor suppressor p53 is elicited by enhanced hdm2‐mediated degradation of p53. Secondary glioblastomas, on the other hand, show inactivating p53 mutations (mut) in 40% of the cases. Based on these observations, reactivating the function of p53 might hold promise for treatment of GBM. In wt p53 tumors showing increased hdm2 levels, the therapeutic strategy might be to inhibit the activity of hdm2 by treatment with small molecules like nutlin‐3. For mut p53 glioblastomas, p53 function might be restored using small chemical entities such as PRIMA‐1. Drug Dev. Res. 67:790–800, 2006. © 2007 Wiley‐Liss, Inc.
A process for fabricating flexible reflective display devices using a composite film of ferroelectric liquid crystal and polymer
Authors: Sato Hiroto , Fujikake Hideo , Murashige Takeshi , Kikuchi Hiroshi , Kurita Taiichiro , Sato Fumio 
Published: January 2007

AbstractWe have developed a process for fabricating flexible reflective display devices using thin composite films of aligned polymer‐monostabilized ferroelectric liquid crystals encased between plastic substrates. In order to precisely control the thickness of these films, photolithography is used to fabricate spacer posts on a substrate, and a printing technique that can form a liquid crystal/monomer solution film on the substrate uniformly. Control voltages are applied to the layer via transparent electrodes; in order to prevent a short circuit between these electrodes, an insulator layer is also formed on the other substrate. Once the two substrates are attached to one another, polymer walls and fibers are created in the liquid crystal layer between the two substrates by photopolymerization‐induced phase separation which was induced by two‐step exposure of ultraviolet light. A fabricated device is sandwiched between a polarizer and a diffuse mirror to make a reflective display. Uniform display operation was obtained when the device was driven with a voltage, even when the device was bent with a 5‐cm radius of curvature. © 2007 Wiley Periodicals, Inc. Electron Comm Jpn Pt 2, 90(2): 33 – 39, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecjb.20192 Copyright © 2004 Wiley Periodicals, Inc.
Isolation and Characterization of ZnII and HgII Coordination Polymers with a Designed Azo‐Aromatic Ligand: Identification of Micrometer‐ and Nanometer‐Sized Particles
Authors: Banerjee Priyabrata , Kar Soumitra , Bhaumik Asim , Lee Gene‐Hsiang , Peng Shie‐Ming , Goswami Sreebrata 
Published: January 2007

AbstractControlled layering of the deprotonated methanolic solution of the azo‐aromatic ligand [L3]– (HL3 = 2‐[3‐(pyridylamino)phenylazo]pyridine) over the aqueous/methanolic solutions of metal chlorides MCl2 (M = Zn, Hg) afforded nano‐ and micrometer‐sized particles of the metal–organic polymeric complexes of [HgCl(C16H12N5)]∞ (1) and [ZnCl(C16H18N5O3)]∞ (2). Time‐dependent growth of the above particles is followed by the SEM and TEM analyses of the samples at different time intervals. The X‐ray structure of the mercury polymer reveals that two infinite 1D, zigzag chains composed of [HgCl(L3)]∞ units run along the a axis antiparalelly. The polynuclear Zn compound, in contrast, agglomerates fast to form hemispherical microcrystals with a diamondoid surface morphology, and no suitable X‐ray quality crystal of this complex could be isolated. Powder XRD analyses of the samples as well as thermogravimetric analysis (TGA) are used for their characterization. Unusually, these metal–organic polymers of the reference d10 metal ions are green and absorb in the low‐energy region of the visible spectrum, 660–675 nm. Semiempirical calculations on a representative complex 1 suggest that the transitions in the complexes involve ligand orbitals. These also show multiple emissions in the blue‐green region. The Zn complex, which is microporous, shows reversible adsorption/desorption of N2 and H2 gasses. The mercury polymer, on the other hand, shows poor adsorption ability. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Characterization of liver disease and lipid metabolism in the Niemann‐Pick C1 mouse
Authors: Garver William S. , Jelinek David , Oyarzo Janice N. , Flynn James , Zuckerman Matthew , Krishnan Kumar , Chung Byung H. , Heidenreich Randall A. 
Published: January 2007

AbstractNiemann‐Pick type C1 (NPC1) disease is an autosomal‐recessive cholesterol‐storage disorder characterized by liver dysfunction, hepatosplenomegaly, and progressive neurodegeneration. The NPC1 gene is expressed in every tissue of the body, with liver expressing the highest amounts of NPC1 mRNA and protein. A number of studies have now indicated that the NPC1 protein regulates the transport of cholesterol from late endosomes/lysosomes to other cellular compartments involved in maintaining intracellular cholesterol homeostasis. The present study characterizes liver disease and lipid metabolism in NPC1 mice at 35 days of age before the development of weight loss and neurological symptoms. At this age, homozygous affected (NPC1−/−) mice were characterized with mild hepatomegaly, an elevation of liver enzymes, and an accumulation of liver cholesterol approximately four times that measured in normal (NPC1+/+) mice. In contrast, heterozygous (NPC1+/−) mice were without hepatomegaly and an elevation of liver enzymes, but the livers had a significant accumulation of triacylglycerol. With respect to apolipoprotein and lipoprotein metabolism, the results indicated only minor alterations in NPC1−/− mouse serum. Finally, compared to NPC1+/+ mouse livers, the amount and processing of SREBP‐1 and ‐2 proteins were significantly increased in NPC1−/− mouse livers, suggesting a relative deficiency of cholesterol at the metabolically active pool of cholesterol located at the endoplasmic reticulum. The results from this study further support the hypothesis that an accumulation of lipoprotein‐derived cholesterol within late endosomes/lysosomes, in addition to altered intracellular cholesterol homeostasis, has a key role in the biochemical and cellular pathophysiology associated with NPC1 liver disease. J. Cell. Biochem. 101: 498–516, 2007. © 2007 Wiley‐Liss, Inc.
CCR2 expression correlates with prostate cancer progression
Authors: Lu Yi , Cai Zhong , Xiao Guozhi , Liu Yulin , Keller Evan T. , Yao Zhi , Zhang Jian 
Published: January 2007

AbstractAlthough the primary role of chemokines and their receptors is controlling the trafficking of leukocytes during inflammatory responses, they also play pleoitropic roles in cancer development. There is emerging evidence that cancer cells produce chemokines that induce tumor cell proliferation or chemotaxis in various cancer types. We have previously reported that MCP‐1 acts as a paracrine and autocrine factor for prostate cancer (PCa) growth and invasion. As the cellular effects of MCP‐1 are mediated by CC chemokine receptor 2 (CCR2), we hypothesized that CCR2 may contribute PCa progression. Accordingly, we first determined CCR2 mRNA and protein expression in various cancer cell lines, including PCa and other cancer types. All cells expressed CCR2 mRNA and protein, but in PCa, more aggressive cancer cells such as C4‐2B, DU145, and PC3 expressed a higher amount of CCR2 compared with the less aggressive cancer cells such as LNCaP or non‐neoplastic PrEC and RWPE‐1 cells. Further, we found a positive correlation between CCR2 expression and PCa progression by analyzing an ONCOMINE gene array database. We confirmed that CCR2 mRNA was highly expressed in PCa metastatic tissues compared with the localized PCa or benign prostate tissues by real‐time RT‐PCR. Finally, CCR2 protein expression was examined by immunohistochemical staining on tissue microarray specimens from 96 PCa patients and 31 benign tissue controls. We found that CCR2 expression correlated with Gleason score and clinical pathologic stages, whereas lower levels of CCR2 were expressed in normal prostate tissues. These results suggest that CCR2 may contribute to PCa development. J. Cell. Biochem. 101: 676–685, 2007. © 2007 Wiley‐Liss, Inc.
Overview of bearing alloy corrosion in ester base fluids
Authors: Torbacke M. 
Published: January 2007

AbstractThe corrosion of soft metals in ester base fluids was studied. Leaded red brass, babbitt, lead and tin were investigated in different natural and synthetic ester base fluids. The base fluids were tested neat or with added oleic acid to model oxidation and hydrolysis. In a few experiments, water was added. The metal specimens were brought into contact with the base fluid under either static or dynamic conditions. The corrosion degree was measured both on the metal specimen (gravimetrically) and in the oil (wear metal analysis). Larger weight losses were observed for the babbitt material than for the leaded red brass. A higher corrosion rate was observed for ester base fluids with a lower hydrolytic stability. Experiments under dynamic conditions gave rise to higher rates of corrosion. Generally, higher corrosion rates were observed for high levels of added oleic acid. Additionally, a polished specimen surface seemed to promote corrosion in this work. Copyright © 2006 John Wiley & Sons, Ltd.
Phase transition thresholds for some Friedman‐style independence results
Authors: Weiermann Andreas 
Published: January 2007

AbstractWe classify the phase transition thresholds from provability to unprovability for certain Friedman‐style miniaturizations of Kruskal's Theorem and Higman's Lemma. In addition we prove a new and unexpected phase transition result for ε0. Motivated by renormalization and universality issues from statistical physics we finally state a universality hypothesis. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
On superstable groups with residual properties
Authors: Ould Houcine Abderezak 
Published: January 2007

AbstractGiven a pseudovariety 𝒞, it is proved that a residually‐𝒞 superstable group G has a finite seriesG 0 ⊴ G 1 ⊴ · · · ⊴ G n = G such that G 0 is solvable and each factor G i +1/G i is in 𝒞 (0 ≤ i ≤ n – 1). In particular, a residually finite superstable group is solvable‐by‐finite, and if it is ω ‐stable, then it is nilpotent‐by‐finite. Given a finitely generated group G, we show that if G is ω ‐stable and satisfies some residual properties (residual solvability, residual finiteness, …), then G is finite. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The polynomial hierarchy for some structures over the binary words
Authors: Nübling Herwig 
Published: January 2007

AbstractFor each k > 0 we construct an algebraic structure over which the polynomial hierarchy collapses at level k. We also find an algebraic structure over which the polynomial hierarchy does not collapse. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Editorial: Math. Log. Quart. 1/2007
Authors: Hemmerling Armin 
Published: January 2007

AbstractDear Readers,A happy and successful 2007 to all of you.I wish to draw your attention again to an enlargement of the Editorial Board of our journal. We are pleased to welcome three new members: Ramon Jansana (Barcelona), Klaus Meer (Odense), and Andrzej Roslanowski (Omaha). I would like to thank the outgoing member, Peter Koepke (Bonn), for the work he has done in supporting MLQ. Also, it is more than justified that the name of our Editorial Assistant, who always faithfully compiles the final layout, can now be seen at the cover.All readers are once more encouraged to contact the Editorial Office or a member of the Editorial Board with any suggestions concerning the contents or the editorial work of our journal. In particular, proposals for issues devoted to special subjects or conferences are highly welcome. In 2007 there will be two such issues: one will be dedicated to “Trends in Constructive Mathematics” and a further one will deal with “Computability and Complexity in Analysis”.It should finally be mentioned that our publishing house is celebrating its 200th anniversary in 2007. During its whole history, Wiley has grown and evolved and has always been successful in serving the needs of its customers. So we can be sure to have a good background for the further development of our journal. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
N‐isopropylacrylamide–acrylamide copolymers initiated by ceric ammonium nitrate in water
Authors: Erbil Candan , Gökçeören Argun T , Polat Y Ozan 
Published: January 2007

AbstractThe polymerization and copolymerization of N‐isopropylacrylamide (NIPAAm) and acrylamide (AAm) at different compositions, initiated by ceric ammonium nitrate alone, were studied in water at 60 °C. The dependence of the polymerization yield and molecular weight on the reaction temperature, nitrate ion concentration, presence of organic solvent and feed composition were examined by gravimetry, Fourier transform infrared (FTIR) spectroscopy and viscosity. The Viscotek system consists of three on‐line detectors, namely right‐angle light scattering, refractometer and viscometer, which were used to determine the number‐average molecular weight (Mn) and hydrodynamic radius (Rh) of the NIPAAm‐rich copolymers. It was observed that both Mn and Rh values of the copolymers decreased with increasing AAm content in the feed. The reactivity ratios of NIPAAm (2) and AAm (1) were computed by the extended Kelen‐Tüdós method at high conversion, using FTIR analysis, and were found to be r2 = 2.26 and r1 = 0.34 for NIPAAm‐rich copolymers, i.e. heterogeneous copolymers. From the determination of the lower critical solution temperature (LCST), i.e. phase transition of 2.0 wt% aqueous solutions of NIPAAm/AAm copolymers and NIPAAm homopolymer (PNIPAAm), using a UV‐visible spectrometer, it was found that the hydrophilicity and LCSTs of the chains could be changed in a narrow temperature range by controlling the initial compositions. Turbidities (τ) obtained from the absorbance values at three different wavelengths (λ; 400, 500 and 600 nm) were used to interpret the macromolecular phase transition from hydrophilic to hydrophobic structure. The effects of comonomer content and temperature on the coil‐globule transition are discussed in terms of the slopes of the linear plots of log τ versus log λ. Copyright © 2007 Society of Chemical Industry