bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual differences in the completed suicides in Turkey
Authors: Oner Setenay , Yenilmez Cinar , Ayranci Unal , Gunay Yasemin , Ozdamar Kazim 
Published: March 2007

AbstractThe aim of this study was to determine whether there is a difference between men and women in terms of suicide age, suicide method and suicide reason in Turkey. This study recruited 17,327 cases that had committed suicide between 1990 and 2000. Of all the cases who committed suicide during a period of 11 years, 61.1% were men, 38.9% women. The highest suicide score fell into the age group 15–24 (P< 0.001). The most frequently used methods for suicide were self-hanging (48.2%) and use of firearms (19.2%) (P< 0.001). The proportion of those committing suicide taking chemicals (drugs, etc.) was higher in women than in men (P< 0.001). The most frequently seen reasons for suicide were illness and (33.8%) unsatisfactory relationships (33.0%) (P< 0.001, each one). Women committed suicide much more because of unsatisfactory relationships, whereas for men it was due to illness (20.8% and 14.6%, respectively). There were significant differences between men and women in terms of suicide age, suicide method and suicide reason in Turkey. When evaluating suicide cases it is essential that the differences between sexes be taken into consideration.
Cyclosporine A inhibits acetylcholinesterase activity in rats experimentally demyelinated with ethidium bromide
Authors: Mazzanti Cinthia M. , Spanevello Roselia , Ahmed Musthaq , Schmatz Roberta , Mazzanti Alexandre , Salbego Fabiano Z. , Graça Dominguita L. , Sallis Eliza S.V. , Morsch Vera M. , Schetinger Maria Rosa C. 
Published: March 2007

AbstractCyclosporine A is the major immunosuppressive agent used for organ transplantation and for the treatment of a variety of autoimmune disorders such as multiple sclerosis. In this work, we investigated the effect of the cyclosporine A on the acetylcholinesterase activity in the cerebral cortex, striatum, hippocampus, hypothalamus, cerebellum and pons of the rats experimentally demyelinated by ethidium bromide. Rats were divided into four groups: I control (injected with saline), II (treated with cyclosporine A), III (injected with 0.1% ethidium bromide) and IV (injected with 0.1% the ethidium bromide and treated with cyclosporine A). The results showed a significant inhibition (p < 0.05) of acetylcholinesterase activity in the groups II, III and IV in all brain structures analyzed. In the striatum, hippocampus, hypothalamus and pons the inhibition was greater (p < 0.005) when ethidium bromide was associated with cyclosporine A. In conclusion, the present investigation demonstrated that cyclosporine A is an inhibitor of acetylcholinesterase activity and this effect is increased after an event of toxic demyelination of the central nervous system.
Signature of Precambrian extension events in the southern Siberian craton
Authors: Gladkochub D.P. , Donskaya T.V. , Mazukabzov A.M. , Stanevich A.M. , Sklyarov E.V. , Ponomarchuk V.A. 
Published: March 2007

Abstract
We investigate extension events in the southern Siberian craton between 1.8 and 0.7 Ga. Signature of Late Paleoproterozoic within-plate extension in the Northern Baikal region is found in 1674 ± 29 Ma dike swarms. A Mesoproterozoic extension event was associated with intrusion of the 1535 ±14 Ma Chernaya Zima granitoids into the Urik-Iya graben deposits. Neoproterozoic extension recorded in the Sayan-Baikal dike belt (740-780 Ma dike complexes) was concurrent with the breakup of the Rodinia supercontinent and the initiation of the Paleoasian passive margin along the southern edge of the Siberian craton. The scale of rifting-related magmatism and the features of the coeval sedimentary complexes in the southern Siberian craton indicate that Late Paleoproterozoic and Early Mesoproterozoic extension did not cause ocean opening, and the Paleoasian Ocean opened as a result of Neoproterozoic rifting.
Types of paleoisland arcs and back-arc basins in the northeast of the Paleoasian Ocean (from geochemical data)
Authors: Makrygina V.A. , Belichenko V.G. , Reznitsky L.Z. 
Published: March 2007

Abstract
Based on a comparative study of geochemistry of metavolcanics and metasediments of two large terranes, Baikal-Muya and Khamar-Daban-Ol’khon, as well as of the Baikal-Patom passive margin and Olokit accretionary wedge, we have recognized volcanosedimentary series accumulated in the settings of island arcs of different maturities and fragments of volcanosedimentary complexes of back-arc and fore-arc basins. Metabasalts of the Medvezhy and Tyya Formations in the basement of passive-margin sequence and the Olokit Group are similar in geochemistry to plateau basalts and mark the beginning of rifting on the platform periphery. The abundance of metavolcanics and turbidites in the Olokit Group permits this structure to be considered an accretionary wedge of the Baikal-Muya island arc. According to the metavolcanics composition, the Baikal-Muya terrane formed in the environment of oceanic ensimatic island arcs and back-arc and inter-arc basins with the minimum amounts of sediments and contains ophiolite slices. The geochemistry of metavolcanics and metasediments of the Ol’khon, Talanchan, and Slyudyanka complexes evidences their formation in the environment of ensialic back-arc sediment-rich basin (Slyudyanka, Ol’khon, and Svyatoi Nos series), mature island arc (Anga-Talanchan paleoarc, Anga and Talanchan Groups), and fore-arc basin (Khangarul’ Group). According to chemistry and evolution history, all these complexes must be assigned to the Khamar-Daban-Ol’khon terrane.
Late Paleozoic granitoids of western Transbaikalia: magma sources and stages of formation
Authors: Tsygankov A.A. , Matukov D.I. , Berezhnaya N.G. , Larionov A.N. , Posokhov V.F. , Tsyrenov B.Ts. , Khromov A.A. , Sergeev S.A. 
Published: March 2007

Abstract
Geochemical and geochronological studies of the main types of granitoids of the Angara-Vitim batholith (AVB) and granites of the Zaza complex in western Transbaikalia were carried out. U-Pb (SHRIMP-II) and Rb-Sr dating yielded the age of autochthonous gneiss-granites of the Zelenaya Griva massif (325.3±2.8 Ma), quartz syenites of the Khangintui pluton (302.3±3.7 Ma) and intruding leucogranites of the Zaza complex (294.4±1 Ma), monzonites of the Khasurta massif (283.7±5.3 Ma), and quartz monzonites of the Romanovka massif (278.5±2.4 Ma). The U-Pb and Rb-Sr dates show that the Late Paleozoic magmatism in western Transbaikalia proceeded in two stages: (1) 340–320 Ma, when predominantly mesocratic granites of the Barguzin complex, including autochthonous ones, formed, and (2) 310–270 Ma, when most AVB granitoids formed. We suggest that at the early stage, crustal peraluminous granites formed in collision geodynamic setting. At the late (main) stage, magmatism occurred in postorogenic-extension setting and was accompanied by the formation of several geochemical types of granitoids: (1) typical intrusive mesocratic granites of the Barguzin complex, similar to those produced at the first stage; (2) melanocratic granitoids (monzonitoids, quartz syenites), which were earlier dated to the early stage of the AVB evolution; (3) leucocratic medium-alkali (peraluminous) granites of the Zaza intrusive complex; and (4) some alkali-granite and syenite intrusions accompanied by alkaline mafic rocks. The diversity of granitoids that formed at the late stage of magmatism was due to the heterogeneous composition of crust protoliths and different degrees of mantle-magma participation in their formation.
Character of formation of the Erdenet-Ovoo porphyry Cu-Mo magmatic center (northern Mongolia) in the zone of influence of a Permo-Triassic plume
Authors: Berzina A.P. , Sotnikov V.I. 
Published: March 2007

Abstract
The Erdenet-Ovoo magmatic center (EOMC) lies within the North Mongolian magmatic area formed through the interaction of a Permo-Triassic plume with the lithosphere in an environment of active continental margin. Two stages are recognized in the EOMC history: subduction stage with participation of basalt-andesite-dacite-rhyolite series and rifting stage with trachybasalt series. The granitoid magmatism (258–220 Ma) is expressed as the Selenge, Shivota, and ore-bearing porphyry complexes. The formation of the Selenge and Shivota granitoids was preceded by the intrusion of gabbroids. Trachybasalts formed during the granitoid magmatism after the Selenge complex, nearly synchronously with the Shivota and ore-bearing porphyry complexes. At the subduction stage of the EMC evolution, the plume influence is documented from the appearance of gabbros both depleted and enriched in lithophile trace elements similar to volcanic rocks of trachybasalt series and basaltoids of bimodal series in northern Mongolia. The Rb-Sr and Sm-Nd isotope characteristics of the enriched gabbros suggest the participation of a lower mantle source in their formation. The plume, as a heat carrier, led to a large-scale manifestation of volcanism and, obviously, a wide development of basic rocks of this stage at depth. The basic rocks were the source of granitoid magma that produced the Selenge granitoids. The protolith melted in the &gt;50 km thick crust preventing the wide manifestation of basaltoid volcanism in that period. The increased plume influence, rifting, uplift of the region, and extension of the crust favored the basaltoid and granitoid (Shivota and ore-bearing porphyry) magmatism activity.
An evaluation of the impact of a school nutrition programme in Vietnam
Authors: Hall Andrew , Hanh Tran Thi Minh , Farley Katherine , Quynh Tran Pham Nha , Valdivia Frank 
Published: March 2007

AbstractObjectiveTo evaluate the effectiveness of a school nutrition programme on the weight gain and growth of Vietnamese schoolchildren.DesignA proximate cluster evaluation of children in seven schools, in which fortified milk and biscuits supplying 300 kcal of energy were being given on school days, compared with children in 14 nearby schools with no feeding. All children were dewormed.SettingTwenty-one primary schools in Dong Thap Province, Vietnam.SubjectsA cohort of 1080 children in grade 1 of 21 primary schools, and a cross-sectional interview of 400 children in grade 3.ResultsThe programme gave children the equivalent of 90 kcal day− 1 over 17 months. t-Tests showed a small but statistically significant difference between groups in their average gain in weight and height: 3.19 versus 2.95 kg (P < 0.001) and 8.15 versus 7.88 cm (P = 0.008). A multiple-level model showed that the programme was statistically significant after controlling for clustering of children in schools, sex, age and initial underweight (P = 0.024). A significant impact on height was also seen in a regression model, but not when controlling for school. The most undernourished children tended to gain the least weight. There was no evidence of substitution.ConclusionThe programme had a small but significant effect on weight gain, but the most undernourished children benefited the least. Methods need to be developed to target them. This design may offer a means of estimating the impact of school feeding on growth in other programme settings.
IS THERE AN INTELLECTUAL HISTORY OF EARLY AMERICAN WOMEN?
Authors: WINTERER CAROLINE 
Published: March 2007

Catherine Kerrison, Claiming the Pen: Women and Intellectual Life in the Early American South (Ithaca: Cornell University Press, 2005)Susan Stabile, Memory's Daughters: The Material Culture of Remembrance in Eighteenth-Century America (Ithaca: Cornell University Press, 2004)Mary Kelley, Learning to Stand and Speak: Women, Education, and Public Life in America's Republic (Chapel Hill: University of North Carolina Press for the Omohundro Institute of Early American History and Culture, 2006)Consider Abigail Adams. Known to us mostly through over one thousand letters that she exchanged with her husband, John Adams, she was a woman of redoubtable intelligence and energy. Wife of the second president of the United States, she was mother to its sixth. She traveled to France and England, rubbing elbows with dukes and diplomats; she read deeply in history and literature; she supported the literacy of black children; she was a conduit for the American reception of Catharine Macaulay's republican-friendly History of England from the Accession of James I to that of the Brunswick Line (1763–8). The letters between John and Abigail fly so fast and furious, are so full of learned banter and palpable yearning, that their marriage appears strikingly modern, a union of equals. Let us not be deceived. Abigail Adams, like other women of her generation even in the social stratosphere, had no formal schooling, and her erudition was dwarfed by the massive learning bestowed upon John. He had a Harvard BA and read law for three years. He took for granted a vast public arena in which to unleash his colossal, if tortured, political ambitions. Abigail never published a word.
BORDERCROSSINGS: LEVINAS, HEIDEGGER, AND THE ETHICS OF THE OTHER
Authors: BAMBACH CHARLES 
Published: March 2007

Ethan Kleinberg, Generation Existential: Heidegger's Philosophy in France, 1927–1961 (Ithaca, NY: Cornell University Press, 2005)Samuel Moyn, Origins of the Other: Emmanuel Levinas between Revelation and Ethics (Ithaca, NY: Cornell University Press, 2005)
pcaMethods—a bioconductor package providing PCA methods for incomplete data
Authors: Stacklies Wolfram , Redestig Henning , Scholz Matthias , Walther Dirk , Selbig Joachim 
Published: March 2007

AbstractSummary: pcaMethods is a Bioconductor compliant library for computing principal component analysis (PCA) on incomplete data sets. The results can be analyzed directly or used to estimate missing values to enable the use of missing value sensitive statistical methods. The package was mainly developed with microarray and metabolite data sets in mind, but can be applied to any other incomplete data set as well.Availability: http://www.bioconductor.orgContact: selbig@mpimp-golm.mpg.deSupplementary information: Please visit our webpage at http://bioinformatics.mpimp-golm.mpg.de/
Metabolic systems cost-benefit analysis for interpreting network structure and regulation
Authors: Carlson Ross P. 
Published: March 2007

AbstractMotivation: Interpretation of bioinformatics data in terms of cellular function is a major challenge facing systems biology. This question is complicated by robust metabolic networks filled with structural features like parallel pathways and isozymes. Under conditions of nutrient sufficiency, metabolic networks are well known to be regulated for thermodynamic efficiency however; efficient biochemical pathways are anabolically expensive to construct. While parameters like thermodynamic efficiency have been extensively studied, a systems-based analysis of anabolic proteome synthesis ‘costs’ and the cellular function implications of these costs has not been reported.Results: A cost-benefit analysis of an in silico Escherichia coli network revealed the relationship between metabolic pathway proteome synthesis requirements, DNA-coding sequence length, thermodynamic efficiency and substrate affinity. The results highlight basic metabolic network design principles. Pathway proteome synthesis requirements appear to have shaped biochemical network structure and regulation. Under conditions of nutrient scarcity and other general stresses, E.coli expresses pathways with relatively inexpensive proteome synthesis requirements instead of more efficient but also anabolically more expensive pathways. This evolutionary strategy provides a cellular function-based explanation for common network motifs like isozymes and parallel pathways and possibly explains ‘overflow’ metabolisms observed during nutrient scarcity.Contact: alicia@iastate.eduSupplementary information: Supplementary data are available at Bioinformatics online.
EuSplice: a unified resource for the analysis of splice signals and alternative splicing in eukaryotic genes
Authors: Bhasi Ashwini , Pandey Ram Vinay , Utharasamy Suriya Prabha , Senapathy Periannan 
Published: March 2007

AbstractMotivation: Despite increased availability of genome annotation data, a comprehensive resource for in-depth analysis of splice signal distributions and alternative splicing (AS) patterns in eukaryote genomes is still lacking. To meet this need, we have developed EuSplice—a unique splice-centric database which provides reliable splice signal and AS information for 23 eukaryotes.Results: The EuSplice database contains 95 822 AS events and 2.1 million splice signals associated with over 270 000 protein-coding genes. The intuitive, user-friendly EuSplice web interface has powerful data mining and graphics capabilities for inter-genomic comparative analysis of splice signals, putative cryptic splice sites and AS events. Moreover, the seamless integration of splicing data to extensive gene-specific annotations, such as homolog annotations, functional information, mutations and sequence details makes EuSplice a powerful one-stop information resource for investigating the molecular mechanisms of complex splicing events, disease associations and the evolution of splicing in eukaryotes.Availability: http://66.170.16.154/EuSpliceContact: ps@genome.comSupplementary information: Supplementary tables and figures at Bioinfo online.
A new method to measure the semantic similarity of GO terms
Authors: Wang James Z. , Du Zhidian , Payattakool Rapeeporn , Yu Philip S. , Chen Chin-Fu 
Published: March 2007

AbstractMotivation: Although controlled biochemical or biological vocabularies, such as Gene Ontology (GO) (http://www.geneontology.org), address the need for consistent descriptions of genes in different data sources, there is still no effective method to determine the functional similarities of genes based on gene annotation information from heterogeneous data sources.Results: To address this critical need, we proposed a novel method to encode a GO term's semantics (biological meanings) into a numeric value by aggregating the semantic contributions of their ancestor terms (including this specific term) in the GO graph and, in turn, designed an algorithm to measure the semantic similarity of GO terms. Based on the semantic similarities of GO terms used for gene annotation, we designed a new algorithm to measure the functional similarity of genes. The results of using our algorithm to measure the functional similarities of genes in pathways retrieved from the saccharomyces genome database (SGD), and the outcomes of clustering these genes based on the similarity values obtained by our algorithm are shown to be consistent with human perspectives. Furthermore, we developed a set of online tools for gene similarity measurement and knowledge discovery.Availability: The online tools are available at: http://bioinformatics.clemson.edu/G-SESAMEContact: jzwang@cs.clemson.eduSupplementary information: http://bioinformatics.clemson.edu/Publication/Supplement/gsp.htm
BioGuideSRS: querying multiple sources with a user-centric perspective
Authors: Cohen-Boulakia Sarah , Biton Olivier , Davidson Susan , Froidevaux Christine 
Published: March 2007

AbstractSummary: Biologists are frequently faced with the problem of integrating information from multiple heterogeneous sources with their own experimental data. Given the large number of public sources, it is difficult to choose which sources to integrate without assistance. When doing this manually, biologists differ in their preferences concerning the sources to be queried as well as the strategies, i.e. the querying process they follow for navigating through the sources. In response to these findings, we have developed BioGuide to assist scientists search for relevant data within external sources while taking their preferences and strategies into account. In this article, we present BioGuideSRS, a user-friendly system which automatically retrieves instances of data by using BioGuide on top of the sequence retrieval system (SRS). BioGuideSRS is an Applet that can be run from its web page on any system with Java 5.0.Availability: http://www.bioguide-project.netContact: sarahcb@seas.upenn.edu
Development and Characterization of Monoclonal Antibodies and Aptamers against Major Antigens ofMycobacterium aviumsubsp.paratuberculosis
Authors: Bannantine John P. , Radosevich Thomas J. , Stabel Judith R. , Sreevatsan Srinand , Kapur Vivek , Paustian Michael L. 
Published: March 2007

ABSTRACTSpecific antibodies, available in unlimited quantities, have not been produced againstMycobacterium aviumsubsp.paratuberculosis, the bacterium that causes Johne's disease (JD). To fill this gap in JD research, monoclonal antibodies (MAbs) againstM. aviumsubsp.paratuberculosiswere produced from BALB/c mice immunized with a whole-cell extract ofM. aviumsubsp.paratuberculosis. A total of 10 hybridomas producing MAbs to proteins ranging from 25 to 85 kDa were obtained. All MAbs showed some degree of cross-reactivity when they were analyzed against a panel of whole-cell protein lysates comprising seven different mycobacterial species. The MAbs were characterized by several methods, which included isotype analysis, specificity analysis, epitope analysis, reactivity in immunoblot assays, and electron microscopy. The identities of the antigens that bound to two selected MAbs were determined by screening anM. aviumsubsp.paratuberculosislambda phage expression library. This approach revealed that MAb 9G10 detects MAP1643 (isocitrate lyase) and that MAb 11G4 detects MAP3840 (a 70-kDa heat shock protein), two proteins present in high relative abundance inM. aviumsubsp.paratuberculosis. The epitopes for MAb 11G4 were mapped to the N-terminal half of MAP3840, whereas MAb 9G10 bound to the C-terminal half of MAP1643. Aptamers, nucleic acids that bind to specific protein sequences, against the hypothetical protein encoded by MAP0105c were also generated and tested for their binding toM. aviumsubsp.paratuberculosisas well as other mycobacteria. These detection reagents may be beneficial in many JD research applications.
Immune Modulator Adamantylamide Dipeptide Stimulates Efficient Major Histocompatibility Complex Class I-Restricted Responses in Mice
Authors: Becker Pablo D. , Nörder Miriam , Guzmán Carlos A. , Grinstein Saul 
Published: March 2007

ABSTRACT

Adamantylamide
l
-alanyl-
d
-isoglutamine (AdDP) is a synthetic adjuvant which belongs to the family of the desmuramyl peptides. AdDP exerts its adjuvant properties when it is administered either by the parenteral or by the mucosal route, leading to the elicitation of strong humoral responses at both the systemic and the mucosal levels. However, very little is known about the effect of AdDP on cellular immunity. Here we demonstrate that AdDP is able to stimulate cellular responses, which are characterized by the release of gamma interferon by CD8
+
T cells when they are restimulated with a major histocompatibility complex class I-restricted peptide and strong in vivo lymphocyte-mediated cytotoxic activity. The capacity of AdDP to stimulate the elicitation of both cellular and humoral adaptive responses makes this adjuvant a promising tool for the development of mucosal vaccine formulations.