bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immature monocytes from G-CSF-mobilized peripheral blood stem cell collections carry surface-bound IL-10 and have the potential to modulate alloreactivity
Authors: Fraser A R , Cook G , Franklin I M , Templeton J G , Campbell M , Holyoake T L , Campbell J D M 
Published: August 2006

Abstract
Production of the anti-inflammatory cytokine IL-10 by monocytes has been implicated as a probable negative regulator of graft-versus-host disease (GvHD) in patients undergoing allogeneic stem cell transplants (SCT). Monocytes from G-CSF-mobilized peripheral blood stem cell (gmPBSC) collections have been reported to produce more IL-10 than unmobilized monocytes in response to proinflammatory factors such as LPS. Why this should occur is unclear. In this study, monocyte phenotype and IL-10 localization and release were investigated in PB mononuclear cells (MNC) from 27 healthy donors mobilized for allogeneic SCT and from 13 patients with hematological malignancies mobilized for autologous SCT. All isolates contained elevated total percentages of monocytes in comparison with unmobilized PB, a high proportion of which displayed an immature phenotype. Stimulation of gmPB MNC with an inflammatory stimulus [fixed Staphylococcus aureus cells (SAC)] induced rapid up-regulation of CD14, indicating conversion to mature status. Localization studies indicated that IL-10 was predominantly present, bound on the surface of CD64+/CD14low/neg immature monocytes. Inflammatory stimuli (LPS, polyinosinic:polycytidylic acid, or SAC) induced release of variable quantities of IL-10 from the cell surface. MNC, separated into surface IL-10-positive or -negative fractions, differed in their ability to stimulate alloreactivity in MLR, and IL-10+ MNC induced significantly lower levels of proliferation than IL-10− MNC. Thus, the subset of immature monocytes carrying surface-bound IL-10 in gmPB has the potential to modulate alloreactivity and GvHD after allogeneic SCT through cell-to-cell contact and released IL-10.
Clinical Activity of Pertuzumab (rhuMAb 2C4), a HER Dimerization Inhibitor, in Advanced Ovarian Cancer: Potential Predictive Relationship With Tumor HER2 Activation Status
Authors: Gordon Michael S. , Matei Daniela , Aghajanian Carol , Matulonis Ursula A. , Brewer Molly , Fleming Gini F. , Hainsworth John D. , Garcia Agustin A. , Pegram Mark D. , Schilder Russell J. , Cohn David E. , Roman Lynda , Derynck Mika K. , Ng Kimmie , Lyons Benjamin , Allison David E. , Eberhard David A. , Pham Thinh Q. , Dere Randall C. , Karlan Beth Y. 
Published: August 2006

Purpose Ovarian cancers (OCs) frequently have HER2 activation in the absence of HER2 overexpression. Pertuzumab, a humanized antibody that prevents HER2 dimerization and inhibits multiple HER-mediated pathways, was studied in a phase II, multicenter trial in advanced, refractory OC. Patients and Methods Sixty-one patients (cohort 1) with relapsed OC received a loading dose of 840 mg pertuzumab intravenously followed by 420 mg every 3 weeks; 62 patients (cohort 2) received 1,050 mg every 3 weeks. Response rate was the primary end point. Fresh tumor biopsies were obtained in cohort 1 to assay for phosphorylated HER2 (pHER2). Results Median age was 57 years and median number of prior chemotherapy regimens was five. Fifty-five patients in cohort 1 and 62 patients in cohort 2 were assessable for efficacy. There were five partial responses (response rate [RR] = 4.3%; 95% CI, 1.7% to 9.4%), eight patients (6.8%) with stable disease (SD) lasting at least 6 months, and 10 patients with CA-125 reduction of at least 50% (includes two partial responses and four patients with SD ≥ 6 months; total clinical activity, 14.5%). Median progression-free survival (PFS) was 6.6 weeks. Eight of 28 tumor biopsies (28.6%) were pHER2+ by enzyme-linked immunosorbent assay (ELISA; without gene amplification). Median PFS for pHER2+ patients was 20.9 weeks (n = 8) versus 5.8 weeks for pHER2− (n = 20; P = .14) and 9.1 weeks for unknown pHER2 status (n = 27). Pertuzumab was well tolerated with diarrhea in 69.1% (11.4% grade 3, no grade 4). Five patients had asymptomatic left ventricular ejection fraction decreases to less than 50% (one confirmed by central facility). Conclusion Pertuzumab is well tolerated with a RR of 4.3% in heavily-pretreated OC patients. Further studies on pHER2 as a diagnostic are warranted.
Efficacy of Adjuvant Radiotherapy of the Tumor Bed on Local Recurrence of Adrenocortical Carcinoma
Authors: Fassnacht Martin , Hahner Stefanie , Polat Buelent , Koschker Ann-Cathrin , Kenn Werner , Flentje Michael , Allolio Bruno 
Published: August 2006

Abstract
Context: Local tumor recurrence is common in adrenocortical carcinoma (ACC) and is the most frequent cause for reoperation. Although radiotherapy is often considered ineffective in the treatment of ACC, the limited number of available studies does not support this statement.
Objective: The objective of the study was investigation of adjuvant tumor bed irradiation in the treatment of ACC.
Design: We performed a retrospective analysis.
Patients: The German ACC Registry (n = 285) was screened for patients who had received tumor bed radiotherapy in an adjuvant setting (no macroscopic evidence for residual disease after surgery). Fourteen patients without distant metastases (World Health Organization stage I, one patient; stage II, seven; stage III, three; and stage IV, three) were matched with 14 patients for resection status, adjuvant mitotane treatment, stage, and tumor size. Median follow-up of patients still alive (n = 15) was 37 months.
Main Outcome Measure: Survival without local recurrence and disease-free survival was the main outcome measure.
Results: Local recurrence was observed in two of 14 patients in the radiotherapy group and in 11 of 14 control patients. The probability to be free of local recurrence 5 yr after surgery differed significantly [79% (95% confidence interval, 53–100) vs. 12% (0–30); P &lt; 0.01]. However, disease-free and overall survival were not significantly different between the two groups. Acute adverse events related to radiotherapy were mostly mild. One patient developed a partial Budd-Chiari syndrome.
Conclusion: These data from the largest series of ACC patients treated with adjuvant tumor bed irradiation suggest that radiotherapy is effective in reducing the high rate of local recurrence in ACC. A randomized trial in high-risk patients is needed to further evaluate the efficacy of radiotherapy as an adjuvant treatment option in ACC.
Increased Subcutaneous and Epicardial Adipose Tissue Production of Proinflammatory Cytokines in Cardiac Surgery Patients: Possible Role in Postoperative Insulin Resistance
Authors: Kremen Jaromir , Dolinkova Marketa , Krajickova Jana , Blaha Jan , Anderlova Katerina , Lacinova Zdena , Haluzikova Denisa , Bosanska Lenka , Vokurka Martin , Svacina Stepan , Haluzik Martin 
Published: August 2006

AbstractContext: Hyperglycemia and insulin resistance frequently occur in critically ill patients even without a history of diabetes.Objective: Our objective was to study the role of adipose tissue hormonal production in the development of insulin resistance in cardiac surgery patients.Participants, Interventions, and Settings: Fifteen patients with elective cardiac surgery underwent blood sampling before, at the end, and 6, 12, 24, 48, and 120 h after the end of their operation. Epicardial and sc adipose tissue sampling was done at the beginning and at the end of surgery in the Department of Cardiac Surgery.Main Outcome Measures: We measured serum concentrations and sc and epicardial adipose tissue mRNA expression of IL-6, monocyte chemoattractant protein-1 (MCP-1), TNF-α, leptin, resistin, and adiponectin and sc and epicardial adipose tissue mRNA expression of CD14, CD45, and CD68.Results: The rate of insulin infusion required to maintain euglycemia increased up to 7-fold 12 h after the operation, suggesting the development of insulin resistance. Serum IL-6 levels increased 43-fold 12 h after surgery. MCP-1 peaked 6-fold at the end of surgery. Smaller peaks of TNF-α and leptin appeared 6 and 12 h after surgery, respectively. Resistin levels peaked 4-fold 24 h after surgery, but adiponectin levels were not significantly affected. TNF-α and CD45 mRNA expression increased markedly during the operation in sc adipose tissue. IL-6, resistin, and MCP-1 mRNA expression increased in both sc and epicardial adipose tissue. Leptin, adiponectin, CD14, and CD68 mRNA expression did not change significantly.Conclusions: Both sc and epicardial adipose tissue is a source of proinflammatory cytokines in cardiac surgery patients and may contribute to the development of postoperative insulin resistance.
Heterogeneous Rate Parameters of Multi-Step Charge-Transfer Processes for 9,9′-Bianthryl-10,10′-dicarbonitrile. Application of ac Voltammetry with Unusual Phase-Angle Behavior
Authors: Rashwan Farouk , Mohran Hossnia 
Published: August 2006

Abstract
Cyclic and ac voltammetric studies of a 9,9′-bianthryl-10,10′-dicarbonitrile/tetrabutylammonium hexafluorophosphate system in superdry aprotic solvents are presented. The rate parameters were obtained for successive one-electron transfer reactions at a hanging mercury drop electrode (HMDE) and/or a Pt disk electrode. The results of electrode processes were found to be in agreement with the predictions of the Marcus theory for heterogeneous charge-transfer reactions. Quite rare behavior of the phase angle of the Faradaic fundamental alternating currect was observed and is discussed in detail.
Structure-Retention Correlation on Methyl Phenyl Polysiloxane Phases in Capillary Gas Chromatography
Authors: Yamane Yasuhiro , Miyaji Kazuo , Hanafusa Kumi , Hanai Toshihiko , Hatano Hiroyuki 
Published: August 2006

Abstract
The selectivity of phenyl methyl polysiloxane phases was examined from the structure-retention correlations of alkanes, alkanols, alkylbenzenes, chlorobenzenes, and polycyclic aromatic hydrocarbons. Selectivity R* was obtained from plots of van der Waals volume vs. the difference of their logarithm of capacity ratios, and enthalpy of these compounds was calculated from van’t Hoff plot. The enthalpy −ΔH of polycyclic aromatic hydrocarbons was greater on phenyl methyl phases compared to those obtained on 100% methyl polysiloxane phase. The retention time of homologue series of compounds can be predicted from the selectivity or enthalpy, but not for chlorinated benzenes due to the difficulty of the estimation of electron donner effect of chloro group.
Crystal Structure of the Adduct of Thiourea with 2,6-Diethylnaphthalene
Authors: Shindo Takayoshi , Shindo Manabu , Ohnuma Hiroshi , Kabuto Chizuko 
Published: August 2006

Abstract
The crystal structure of 2,6-diethylnaphthalene thiourea adduct was solved by single crystal X-ray diffraction method. The crystal is monoclinic, space group P2l/c, with a = 12.571(3), b = 9.282(2), c = 14.634(3) Å, β = 92.14(2)°, V = 1706.3(6) Å3 and Z = 2. The final R value was 0.083. The structure was composed of thiourea (host) molecules enclosing channels with hexagonal-prism and 2,6-diethylnaphthalene (guest) molecules in the channels. The cross-section of the channel was deformed hexagon. In the channel, the occupying channel length of the guest molecule was 12.571(3) Å
1H NMR Response of Mono[6-(1-pyridinio)-6-deoxy]-α-cyclodextrin to Inorganic Anions
Authors: Mu Ping , Okada Takuya , Iwami Nakamasa , Matsui Yoshihisa 
Published: August 2006

Abstract
The chemical shifts (δ) of some 1H NMR signals given by mono[6-(1-pyridinio)-6-deoxy]-α-cyclodextrin (1) in D2O were significantly changed by the addition of alkali salts of chaotropic anions such as Br−, I−, SCN−, N3−, NO3−, and ClO4−. However, only small changes in δ were brought about by the addition of alkali salts of antichaotropic anions such as F−, Cl−, SO42−, H2PO4−, and HPO42−. The addition of the chaotropic anions caused a marked downfield shift in the signal of a C(5)–H located in the interior of the cavity of 1, and a marked upfield shift in the signal of one of the C(6)–H’s involved in the unsubstituted glucopyranose rings of 1. These facts indicate that the anions are included within the cavity and attract the pyridinio group of 1 close to the C(6)–H. The signal of the α-H’s in the pyridinio group showed a significant downfield shift with the addition of the alkali salts of Br−, I−, and SCN−, which form charge-transfer complexes with 1.
Electrochemical Characteristics of an Insulating Polymer-Modified Electrode Prepared by Electrochemical Polymerization
Authors: Kawai Tsuyoshi , Nagame Seigo , Nakazono Masahiro , Yoshino Katsumi 
Published: August 2006

Abstract
The electrochemical polymerization of 1,4-bis(2-methylstyryl)benzene and the electrochemical behavior of the resulting polymer-modified electrode have been studied. The rapidly decreasing polymerization current of the 1,4-bis(2-methylstyryl)benzene can be attributed to the passivation effect of the resulting polymer coating. The polymer-modified electrode showed an electrochemical response in an aqueous electrolyte solution corresponding to solute electroactive ions. The electrochemical behavior was dependent on the polymerization charge and the size of the electroactive ions. The polymer-modified electrode is applicable as the selective electrode for electroactive ions and molecules in an electrolyte solution containing electroactive bacterial cells.
Theoretical Study of the Rates and Mechanism of the Gas-Phase Reaction H + HN3 → NH2 + N2
Authors: Fueno Takayuki , Takane Shin-ya 
Published: August 2006

Abstract
Reaction of the hydrogen atom with hydrazoic acid HN3 in the gas phase has been investigated theoreticallly. Tracing of the reaction path by the SCF procedure based on the 6-31G (d,p) basis functions has shown that the reaction proceeds through an initial rate-determining hydrogen atom addition to HN3 giving a doublet radical H2N3, which is subsequently self-decomposed into NH2 + N2. The barrier height for the initial addition step calculated by the MRD-CI method employing the [4s2p1d] basis sets is 21 kJ mol−1 (with the vibrational zero-point energy correction). The bimolecular rate constants for the overall reaction calculated by the conventional transition state theory combined with appropriate tunneling corrections are found to agree well with the experimental data reported over the temperature range 300 to 500 K.
Aromaticity of Multiply Charged Fullerene Ions
Authors: Aihara Jun-ichi , Hosoya Haruo 
Published: August 2006

Abstract
The topological resonance energies (TREs) indicate that mono- to hexaanions of C60 are as aromatic as the neutral species. The tendency of multiply charged C60 anions to retain their own spherical conjugated systems can be attributed to aromatic character. Tetraanions of C28, C36, and C44 are likewise predicted to be highly aromatic. Thus, the formation of metallofullerenes, such as U@C28, U@C36, and U@C44, can be rationalized in terms of aromaticities of the ligands.
Thermal Condensation of Phosphorodiamidic Acid: HPO2(NH2)2
Authors: Kowalczyk K , Parent Y , Palavit G 
Published: August 2006

Abstract
Phosphorodiamidic acid disappears when it is heated at 110 °C. It condenses, giving the ammonium salt of P,P′-diamidoimidodiphosphoric acid. The value of the enthalpy for this reaction is −3.6 kJ mol−1. We determined the apparent activation energy for the condensation reaction by two different methods: -Differential Scanning Calorimetry, -Measuring out ammonium. We obtained by these two methods the same apparent activation energy: 120 kJ mol−1.
The Preparations, Properties and Structures of trans-[Rh(CN)2(tn)2]+
Authors: Odano Naomi , Harada Kazumasa , Urushiyama Akio 
Published: August 2006

Abstract
The title dicyano-complex of Rh(III) was newly synthesized. Stepwise ligand substitutions in an aqueous medium through trans-[RhCl2(tn)2]+, trans-[Rh(SO3)2(tn)2]−, trans-[Rh(CN)(SO3)(tn)2], and trans-[Rh(CN)Cl(tn)2]− were studied. The final substitution of Cl− of trans-[Rh(CN)Cl(tn)2]− by CN− was effected in a mixed medium of DMSO, ethanol, and H2O (8 : 1 : 1). The ligand field tetragonal parameters of Dt ca. −380 cm−1 were estimated based on the lower d–d absorption maximum at 36100 cm−1. The sharp IR peaks of ν (C≡N) were observed at 2115 cm−1 (nitrate) and 2116, 2131 cm−1 (perchlorate). The slight splitting detected for solid compound of the perchlorate was attributed to the presence of a structurally different complex species with respect to the Rh–C≡N bondings in the crystal. The X-ray crystal data are: trans-[Rh(CN)2(tn)2](NO3): monoclinic, space group P21/n, a = 11.626(4), b = 6.3624(6), c = 10.026(3) Å, β = 113.54(4)°, Dm = 1.78, Dc = 1.784 g cm−3, Z = 2; trans-[Rh(CN)2(tn)2](ClO4): triclinic, space group , a = 9.230(5), b = 12.690(3), c = 6.861(2) Å, α = 101.36(3)°, β = 106.10(3)°, γ = 76.42(3)°, Dm = 1.80, Dc = 1.800 g cm−3, Z = 2. In these two crystal lattices, the trans-[Rh(CN)2(tn)2]+ cations occupy the special positions of the inversion center, and the Rh-tn six-membered chelate rings appear in the chair form. While all of the bond distances and angles were well conserved, an appreciable variation appeared in the dihedral angles defined in the chair chelate rings (N–Rh–N : N–C···N–C and N–C···N–C : C–C–C). This structural variation in the Rh-tn chelate rings is responsible for the complicated splittings of the IR bands of the perchlorate, especially, in the CH2 rocking region of 880—970 cm−1. Other important geometrical data of the complex are (in mean values): Rh–N = 2.09, Rh–C = 2.03 Å, N–Rh–N (in chelate ring) = 91.8°
Reaction of the Group 15 Metalloid Amides with Diketene by 1,4-Addition Mode
Authors: Ando Fumio , Mio Ryosuke , Koketsu Jugo 
Published: August 2006

Abstract
(Dialkylamino)dimethylarsines, (dimethylamino)diphenylarsine, and (dialkylamino)dimethylstibines react with diketene to yield N,N-dialkyl-4-dimethylarsino-3-oxobutanamides, N,N-dimethyl-4-diphenylarsino-3-oxobutanamide, and N,N-dialkyl-4-dimethylstibino-3-oxobutanamides, respectively. These group 15 metalloid-substituted 3-oxobutanamides exist as keto-enol tautomers and the keto isomers are predominant in solution or in neat state. This reaction is the first example of 1,4-addition of heteroatom-nitrogen bond to diketene.
The Influence of β-Alanine and 4-Aminobutyric Acid Residues on the Solubility of Peptides Containing Them
Authors: Lee Jin-Shik , Murakawa Yuka , Hanami Akira , Narita Mitsuaki 
Published: August 2006

Abstract
The influence of unnatural amino acid residues, i.e., β-alanine (β-Ala) and 4-aminobutyric acid (γ-Aba) residues, on the solubility of peptides containing them was studied in organic solvents. The difference between the solubilities of peptides containing β-Ala, γ-Aba, Pro, Gly, Leu, and Asp(OBzl) was investigated by the solvent titration method by use of IR absorption spectra. The order of their solubilities is as follows, peptides containing Pro &gt; β–Ala &gt; γ–Aba &gt; Asp(OBzl) &gt; Leu &gt; Gly. The extreme high solubility of peptides containing Pro residues is explained by the concept of “Peptide Segment Separation” caused by the tertiary peptide bond of the Pro residue. The high solubility of peptides containing β-Ala or γ-Aba residues is believed to be due to the difference of the geometries of the Gly, β-Ala, and γ-Aba residues. Their effective concentration seemed to be less important than their geometry. The role of β-Ala and γ-Aba residues in the solubility of peptides is similar to the role of Pro residues rather than Asp(OBzl), Gly, and Leu residues.
Simple One-Pot Synthesis of Thieno[2,3-b]thiophene Derivatives under Solid–Liquid PTC Conditions. Useful Starting Material for the Synthesis of Biological Active Compounds
Authors: El-Saghier Ahmed M M 
Published: August 2006

Abstract
A variety of thieno[2,3-b]thiophenes were prepared under phase-transfer catalysis conditions. The reaction of diethyl 3,4-dimethylthieno[2,3-b]thiophene-2,5-dicarboxylate with hydrazine hydrate gave the corresponding hydrazide derivative which was also subjected to react with acetylacetone, ethyl acetoacetate, malononitrile, CS2, phenyl isothiocyanate, p-chlorobenzaldehyde and diazotization to afford the described compounds. Treatment of 2,5-bis(azidocarbonyl)-3,4-dimethylthieno[2,3-b]thiophene with ethyl cyanoacetate, diethyl malonate or malononitrile gave the corresponding triazole derivatives.
Syntheses, Structures, and Properties of 2,3,6,7-Tetrathiabenzo[1,3-cd:4,6-c′d′]dipentalene and Its Methyl, Ethyl, Methylthio, and Ethylthio Derivatives: Novel Fused Polynuclear Heteroarenes
Authors: Otsubo Tetsuo , Kono Yasuhiro , Hozo Norio , Miyamoto Hisakazu , Aso Yoshio , Ogura Fumio , Tanaka Takanori , Sawada Masami 
Published: August 2006

Abstract
The title heteroarene (TBD) isoelectronic with perylene was synthesized by way of a dimerization of thieno[2,3-b]thiophene. In addition, 1,4,5,8-tetramethyl, tetraethyl, tetrakis (methylthio), and tetrakis (ethylthio) derivatives were readily obtained from TBD. An X-ray crystallographic analysis of TBD demonstrated that the molecular structure is quite planar and symmetrical, but strained in the bond angles. The crystal structure comprises herringbone-type column stacking with intercolumnar heteroatomic interactions. TBD showed the same oxidation potential as did perylene, and like perylene, formed an iodine complex with a relatively high electrical conductivity of 0.11 S cm−1. On the other hand, all of the TBD derivatives gave poorly conductive iodine complexes. In addition, TBD and the derivatives formed charge-transfer complexes with strong electron acceptors, such as 7,7,8,8-tetracyanoquinodimethane (TCNQ), 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (TCNQF4), 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ), and 1,1,2,3,4,4-hexacyano-1,3-butadiene (HCBD). These π-complexes, however, were mostly of low conductivity. The electrolyses of TBP gave powdery conductive polymers, whereas those of tetrakis (methylthio) TBD gave crystalline radical cation salts with conductivities of the order of 10−3 S cm−1.
Base-Promoted Rearrangement of 1,5-Dibromopentacyclo[5.3.0.02,5.03,9.04,8]decane-6,10-dione: Easy Entry of a Novel Cage System, 10-Oxa-9-oxopentacyclo[5.3.0.02,4.03,6.05,8]decane
Authors: Nigo Tomohiro , Hasegawa Takeshi , Kuwatani Yoshiyuki , Ueda Ikuo 
Published: August 2006

Abstract
The Diels-Alder dimerization of 2-bromo-2,4-cyclopentadienone ethylene acetal (2) gave endo-2,7-dibromodicyclopentadiene-1,8-dione 1,8-bis (ethylene acetal) (3) as a minor product in a 4.5% yield. Ultraviolet irradiation of 5 led to dimerization product 7. Deacetalization was accomplished by treating with concentrated sulfuric acid to give 1,5-dibromopentacyclo[5.3.0.02,5.03,9.04,8]decane-6,10-dione (9). Compound 9 was converted into a new cage system, 10-oxa-9-oxopentacyclo[5.3.0.02,4.03,6.05,8]decane, in a high yield by treating with 5% aqueous potassium hydroxide at 80 °C.
Mechanistic Study of Acid-Catalyzed Proton Exchange in Thioamide and Thiolactams
Authors: Wang Wei-Hsien , Cheng Pai-Hui , Hsieh Hsing-Ching 
Published: August 2006

Abstract
The kinetics of acid-catalyzed proton exchange in a series of thiolactams (5- to 7-membered ring) and N-methylthioacetamide were studied. Kinetic data were observed by NMR line-broadening and computer simulation methods. The second-order rate constants of all the thiolactams and N-methylthioacetamide are within the same order of magnitude. It is concluded that the imidic acid mechanism is dominant in thiolactams and N-methylthioacetamide.
Lability of Soluble Copper(II) Complex in River Waters in the Urban Area
Authors: Kawamoto Hiroshi , Yokoyama Ryo , Tsunoda Kin-ichi , Akaiwa Hideo 
Published: August 2006

Abstract
Hourly variation of the lability of soluble copper(II) complex in water samples from the Kiryu River in Gunma prefecture was investigated. By considering the relationship between the lability of soluble copper(II) complexes and the copper(II) complexing capacity, the lability was found to reflect the presence of weak CuII complexes.