bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival Predictors of Radioiodine-refractory Differentiated Thyroid Cancer Treated With Lenvatinib in Real Life
Authors: Marotta Vincenzo , Rocco Domenico , Crocco Anna , Deiana Maria Grazia , Martinelli Ruggero , Di Gennaro Francesca , Valeriani Mariafelicia , Valvano Luca , Caleo Alessia , Pezzullo Luciano , Faggiano Antongiulio , Vitale Mario , Monti Salvatore 
Published: March 2024

Abstract

Context
Lenvatinib is approved for the treatment of radioiodine-refractory differentiated thyroid cancer (RR-DTC). The definition of predictive factors of survival is incomplete.

Objective
To identify pre- and posttreatment survival predictors in a real-life cohort of RR-DTC treated with lenvatinib.

Design
Multicenter, retrospective, cohort study.

Setting
3 Italian thyroid cancer referral centers.

Participants
55 RR-DTC treated with lenvatinib.

Main Outcome Measures
Progression-free survival (PFS) and overall survival (OS).

Results
Lenvatinib was the first-line kinase-inhibitor in 96.4% of subjects. Median follow-up was 48 months. Median PFS and OS were 26 [95% confidence interval (CI) 19.06-32.93] and 70 months (95% CI 36-111.99), respectively. Pretreatment setting: Eastern Cooperative Oncology Group (ECOG) performance status was independently related to PFS [P &lt; .001; hazard ratio (HR) 18.82; 95% CI 3.65-97.08: score 0-1 as reference] and OS (P = .001; HR 6.20; 95% CI 2.11-18.20; score 0-1 as reference); radioactive iodine (RAI) avidity was independently related to PFS (P = .047; HR 3.74; 95% CI 1.01-13.76; avid disease as reference). Patients with good ECOG status (0-1) and RAI-avid disease obtained objective response in 100% of cases and achieved a median PFS of 45 months without any death upon a median follow-up of 81 months. Posttreatment setting: the best radiological response independently predicted PFS (P = .001; HR 4.6; 95% CI 1.89-11.18; partial/complete response as reference) and OS (P = .013; HR 2.94; 95% CI 1.25-6.89; partial/complete response as reference).

Conclusion
RR-DTC with good performance status and RAI-avid disease obtains the highest clinical benefit from lenvatinib. After treatment initiation, objective response was the only independent survival predictor.
A Tranifesto for the Dolls
Authors: Zhang Erique , Glover Julian Kevon , Kim Ava L. J. , Kimoto Tamsin , Moore Nathan Alexander , o'neil æryka jourdaine hollis , Ridley LaVelle 
Published: March 2024

AbstractIn this written dialogue, the authors build on a roundtable discussion held at the 2022 annual meeting of the National Women's Studies Association to articulate what a trans femme of color theory might look like, one that positions trans femmes of color not only as objects of study but also as producers of knowledge and subjects central to the field of trans studies.
Beyond Autopoiesis
Authors: Hansen Sid 
Published: March 2024

Abstract
As the notion of biological sex becomes increasingly invested with binary, anti-trans meanings in US discourse, some scholars suggest that “reimagining biology” as diverse and not dichotomous might help affirm trans identities. Instead of ignoring science and emboldening its reductionist forms, it is said that theorists should celebrate trans identities as biological diversity. This essay explores the fraught terrain of this hopeful project. The first section examines how dominant histories of the sex-gender distinction autopoietically flatten trans lives by conflating them with the passive materiality of biological sex. The second section turns to two histories of trans life that challenge this historiographic tendency—Jules Gill-Peterson's Histories of the Transgender Child and C. Riley Snorton's Black on Both Sides. Following Sylvia Wynter's call to forge liminal sciences, the article shows how Gill-Peterson and Snorton reimagine biology by encountering marginalized modes of trans scientific practice. In the margins, gaps, and opacities of the archive, there are encounters with trans experimentation, rearrangements of biology and science that do not “affirm” transness as much as they rebel against the racist order of cis-normativity.
Impact of Cerebral Revascularization on Pial Collateral Flow in Patients With Unilateral Moyamoya Disease Using Quantitative Magnetic Resonance Angiography
Authors: Santhumayor Brandon A. , White Timothy G. , Golub Danielle , Rivera Moses , Turpin Justin , Golombeck David , Ryu Brendan , Shah Kevin , Ortiz Rafael , Black Karen , Katz Jeffrey M. , Dehdashti Amir R. , Langer David J. 
Published: March 2024

BACKGROUND AND OBJECTIVES:
Moyamoya disease (MMD) is a chronic steno-occlusive disease of the intracranial circulation that depends on neoangiogenesis of collateral vessels to maintain cerebral perfusion and is primarily managed with cerebral revascularization surgery. A quantitative assessment of preoperative and postoperative collateral flow using quantitative magnetic resonance angiography with noninvasive optimal vessel analysis (NOVA) was used to illustrate the impact of revascularization on cerebral flow distribution.

METHODS:
A retrospective review of patients with unilateral MMD who underwent direct, indirect, or combined direct/indirect cerebral revascularization surgery was conducted between 2011 and 2020. Using NOVA, flow was measured at the anterior cerebral artery (ACA), ACA distal to the anterior communicating artery (A2), middle cerebral artery (MCA), posterior cerebral artery (PCA), and PCA distal to the posterior communicating artery (P2). Pial flow (A2 + P2) and collateral flow (ipsilateral [A2 + P2])—(contralateral [A2 + P2]) were measured and compared before and after revascularization surgery. Total hemispheric flow (MCA + A2 + P2) with the addition of the bypass graft flow postoperatively was likewise measured.

RESULTS:
Thirty-four patients with unilateral MMD underwent cerebral revascularization. Median collateral flow significantly decreased from 68 to 39.5 mL/min (P = .007) after bypass. Hemispheres with maintained measurable bypass signal on postoperative NOVA demonstrated significant reduction in median collateral flow after bypass (P = .002). Median total hemispheric flow significantly increased from 227 mL/min to 247 mL/min (P = .007) after bypass. Only one patient suffered an ipsilateral ischemic stroke, and no patients suffered a hemorrhage during follow-up.

CONCLUSION:
NOVA measurements demonstrate a reduction in pial collateral flow and an increase in total hemispheric flow after bypass for MMD, likely representing a decrease in leptomeningeal collateral stress on the distal ACA and PCA territories. Further studies with these measures in larger cohorts may elucidate a role for NOVA in predicting the risk of ischemic and hemorrhagic events in MMD.
Evaluation of Peak Power Output in Healthy Adults during Sit-to-Stand and Vertical Jump Assessments
Authors: Keefe Marcos S. , Thiele Ryan M. , Mackey Cameron S. 
Published: March 2024

ABSTRACT

Introduction
Measuring maximal, or peak, power output (Pmax) through vertical jumps (VJ) may not be appropriate for all individuals; the sit-to-stand (STS) test could potentially be more functionally relevant for older adults. However, the reliability of measuring Pmax in conjunction with STS and the relationships between Pmax during STS and VJ are unknown. This study aimed to determine the reliability and relationships of Pmax during VJ and STS assessments using a commercially designed testing device.

Methods
Sixteen healthy males (mean ± standard deviation: age, 24 ± 4 yr; height, 177 ± 7 cm; mass, 86 ± 19 kg) visited the laboratory on two occasions separated by 2–7 d. During each visit, participants performed three maximal STS tests from a table at knee flexions of 90° (STS90) and 120° (STS120) and three countermovement jumps (CMJ) and squat jumps (SJ) in randomized order. Reliability for Pmax during STS and VJ were determined using intraclass correlation coefficients (ICC; model 2,1) and standard errors of the mean (SEM). Systematic variability was examined using separate one-way repeated-measures analyses of variance (ANOVA). Pearson correlation coefficients (r) examined relationships between Pmax as measured during the STS and the VJ.

Results
ANOVA indicated no systematic variability in Pmax across trials (P > 0.05). ICC and SEM expressed as percentages of the mean ranged from 0.958 to 0.978 and 5.586% to 6.396% for STS and from 0.924 to 0.974 and 4.025% to 6.534% for VJ, respectively. Significant positive relationships were observed between Pmax as measured during STS90, STS120, CMJ, and SJ (r = 0.751–0.962, P ≤ 0.001).

Conclusion
Results indicate that commercially designed devices may be highly reliable for assessing Pmax during STS and VJ. STS testing is potentially an effective alternative to VJ for assessing lower-body muscle power.
Bilateral inguinoscrotal swelling: An uncommon presentation of omental cystic lymphangioma
Authors: Viqar Sana , Chandni  , Muhammad Amjad Chaudhary  
Published: March 2024

Abdominal cystic lymphangioma is a rare benign tumour in children. It is often difficult to diagnosis pre-operatively due to a varied spectrum of symptoms. We report a case of a male infant who presented with gross bilateral inguinoscrotal swelling. Provisional diagnosis of congenital communicating hydrocele was made and investigation revealed a large abdominal cyst. Patient underwent explorative laparotomy and the cyst arising from greater omentum, extending into bilateral scrotum, was excised and bilateral herniotomy done. Mass was confirmed to be lymphangioma on biopsy. This case is unique as an abdominal lymphangioma presented solely as inguinoscrotal swelling, with no abdominal symptom. To our knowledge, this is the first case of omental cystic lymphangioma involving both inguinoscrotal regions. Our case suggests that abdominal cystic lymphangioma should be a part of the differential diagnosis in any child with gross inguinoscrotal swelling in whom initial impression is of communicating hydrocele.
doi: https://doi.org/10.12669/pjms.40.5.8255
How to cite this: Viqar S, Chandni, Chaudhary MA. Bilateral inguinoscrotal swelling: An uncommon presentation of omental cystic lymphangioma. Pak J Med Sci. 2024;40(5):---------. doi: https://doi.org/10.12669/pjms.40.5.8255
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transient long-range distance measurement by a Vernier spectral interferometry
Authors: Xu Liang , Wang Kun , Liu Chen , Chen Wenying , Zhang Chi , Zhang Xinliang 
Published: March 2024

Rapid and long-range distance measurements are essential in various industrial and scientific applications, and among them, the dual-comb ranging system attracts great attention due to its high precision. However, the temporal asynchronous sampling results in the tradeoff between frame rate and ranging precision, and the non-ambiguity range (NAR) is also limited by the comb cycle, which hinders the further advancement of the dual-comb ranging system. Given this constraint, we introduce a Vernier spectral interferometry to improve the frame rate and NAR of the ranging system. First, leveraging the dispersive time-stretch technology, the dual-comb interferometry becomes spectral interferometry. Thus, the asynchronous time step is unlimited, and the frame rate is improved to 100 kHz. Second, dual-wavelength bands are introduced to implement a Vernier spectral interferometry, whose NAR is enlarged from 1.5 m to 1.5 km. Moreover, this fast and long-range system also demonstrated high precision, with a 22.91-nm Allan deviation over 10-ms averaging time. As a result, the proposed Vernier spectral interferometry ranging system is promising for diverse applications that necessitate rapid and extensive distance measurement.
Vivências de professores de Biologia e suas perspectivas sobre a formação continuada
Authors: Rodrigues Aline de Queiroz , Nunes Felipe Rosa , Pedreira Ana Júlia Lemos Alves 
Published: March 2024

A atual política educacional brasileira considera a formação continuada como um processo de autorreflexão permanente e uma possibilidade de renovação da prática docente. Conforme o modelo de formação docente prático-reflexivo, o professor constrói novos conhecimentos por meio de reflexões sobre sua prática, o que pode proporcionar melhorias no processo de ensino e de aprendizagem. Uma pesquisa qualitativa foi realizada no ano de 2018, utilizando a aplicação de questionários e entrevistas semiestruturadas, com o objetivo de investigar se os professores graduados em Biologia, atuantes em escolas públicas de Sobradinho/DF e Planaltina/DF, participam de processos de formação continuada. Buscou-se também levantar os recursos metodológicos que, porventura, são utilizados pelos professores para o seu aprimoramento profissional, bem como as principais carências referentes ao tema. Foi possível observar, que a maioria dos professores considera o processo de formação continuada um importante instrumento de ascensão pessoal e profissional, demonstrando que a preocupação com o aprimoramento e com a atualização é constante. Quanto aos recursos metodológicos utilizados no processo de formação continuada, destaca-se o uso da internet e o uso de livros, em ambas as localidades. Além disso, há pouca interação dos professores com as Instituições de Ensino Superior e os aspectos que motivam à adesão ao processo de formação continuada são distintos.
Spleen Stiffness–Based Algorithms Are Superior to Baveno VI Criteria to Rule Out Varices Needing Treatment in Patients With Advanced Chronic Liver Disease
Authors: Vanderschueren Emma , Armandi Angelo , Kwanten Wilhelmus , Cassiman David , Francque Sven , Schattenberg Jörn M. , Laleman Wim 
Published: March 2024

INTRODUCTION:
The Baveno VI criteria have set the stage for noninvasive assessment of compensated advanced chronic liver disease (ACLD). The algorithm combining liver stiffness measurement (LSM, <20 kPa) and platelet count (>150,000/μL) safely avoids screening endoscopy for varices needing treatment (VNT) but identifies only a relatively low number of patients. We aimed to evaluate the value of spleen stiffness measurement (SSM) using spleen-dedicated elastography in ruling out VNT.

METHODS:
In this real-life multicenter retrospective derivation-validation cohort, all consecutive patients with ACLD (defined by LSM ≥10 kPa) with available upper endoscopy, laboratory results, spleen diameter, LSM, and SSM measured with spleen-dedicated transient elastography were included. VNT were defined as medium-to-large varices or small varices with red spots.

RESULTS:
In the derivation cohort (n = 201, 11.9% VNT), SSM demonstrated excellent capability at identifying VNT (area under the receiver operating characteristic curve [AUROC] 0.88), outperforming LSM (AUROC 0.77, P = 0.03) and platelets (AUROC 0.73, P = 0.002). In comparison with Baveno VI criteria (33.8% spared endoscopies), the sequential Baveno VI plus SSM and a novel spleen size and stiffness model were able to increase the number of patients avoiding endoscopy (66.2% and 71.1%, respectively) without missing more than 5% of VNT. These findings were confirmed in an external validation cohort of patients with more advanced liver disease (n = 176, 34.7% VNT) in which the number of spared endoscopies tripled (27.3% and 31.3% for SSM-based algorithms) compared with Baveno VI criteria (8.5%).

DISCUSSION:
Spleen stiffness–based algorithms are superior to Baveno VI criteria in ruling out VNT in patients with ACLD and double the number of patients avoiding screening endoscopy.
Gambaran Tingkat Pengetahuan Kader TB di Kabupaten Batang
Authors: Habibillah Annis Syahri , Martini Martini , Yuliawati Sri , Saraswati Lintang Dian , Hestiningsih Retno 
Published: March 2024

Background: Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Health cadres are one of the important elements that contribute to community empowerment in achieving TB detection. The ability of cadres to mobilize the community is an indicator of success in conveying health messages to the community. Knowledgeable TB cadres are very helpful in controlling pulmonary tuberculosis cases. This study aims to describe the description of the level of knowledge of TB cadres in Batang Regency.Methods: This research is a descriptive observational study using a cross sectional research design. The sample size in this study was 126 respondents using a total sampling technique. The research respondents were all TB cadres who were in the working area of the Batang District Health Office. Interview using a questionnaire. Interview data were processed using the frequency distribution test and descriptive analysis using the SPSS program.Result: Based on the research results, it can be said that most of the cadres are 36-45 years old with an average age of 40.6 years. The majority of cadres have good knowledge (60.3%), and 39.7% of cadres have less knowledge.Conclusion: Most of the cadres are 36-45 years old with the majority of TB cadres having a good level of knowledge. Keywords: Tuberculosis, TB cadres, knowledge, level
Evaluasi Penyelenggaraan Sistem Surveilans Covid-19 Di Kota Bekasi Tahun 2021
Authors: Ajie Muhammad Wahyu Nugraha , Martini Martini , Wurjanto Moh. Arie 
Published: March 2024

Latar Belakang: Coronavirus Disease 2019 (COVID-19) merupakan penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Kondisi terkini kasus penyebaran COVID-19 di Kota Bekasi sudah cukup terkendali. Surveilans epidemiologi COVID-19 merupakan salah satu bentuk upaya pencegahan dan pengendalian penyebaran penyakit ini. Penelitian ini bertujuan untuk mengamati penerapan sistem surveilans COVID-19 di Puskesmas Kota Bekasi.Metode: Penelitian ini merupakan penelitian kuantitatif dengan pendekatan deskriptif observasional dan menggunakan desain studi potong lintang. Responden penelitian adalah petugas surveilans COVID-19 di Puskesmas Kota Bekasi. Besar sampel dalam penelitian ini dihitung dengan menggunakan total sampling. Pengumpulan data dilakukan dengan pengisian angket online dan observasi. Analisis data dilakukan secara deskriptif dan dibandingkan dengan keputusan menteri dan pedoman surveilans.Hasil: Pada penelitian ini dihasilkan bahwa sebagian besar pelaksanaan surveilans COVID-19 yang baik lebih besar proporsinya pada kategori responden usia remaja awal, jenis kelamin laki-laki, tingkat pendidikan lulus S-1 Kesehatan, lama kerja lama (>7 tahun), rangkap tugas/beban kerja, dan kategori atribut surveilans yang tidak sesuai.Simpulan: 1) Petugas Surveilans COVID-19 Kota Bekasi sudah melaksanakan komponen surveilans dengan baik, yaitu dimulai dari kegiatan penemuan kasus, pengumpulan data, pengolahan data, analisis dan interpretasi data, ketersediaan informasi epidemiologi dan kegiatan diseminasi informasi dan umpan balik (feedback) kasus COVID-19, dan 2) Pelaksanaan kegiatan surveilans COVID-19 di Kota Bekasi yang baik lebih besar proporsinya pada puskesmas dengan kategori atribut surveilans yang tidak sesuai. Kata Kunci: COVID-19, Surveilans Epidemiologi, Atribut Surveilans, Puskesmas
Evaluasi Administratif Kebijakan Fasilitas Kesehatan Ibu Hamil Dalam Penanganan Stunting Pada Masa Pandemi Covid-19
Authors: Satria Bhirawa Anuraga Pandjie , Suryoputro Antono , Achadi Nugraheni Sri 
Published: March 2024

Berdasarkan data Dinas Kesehatan tahun 2020, jumlah anak penderita stunting di Kabupaten Semarang sebanyak 3.817 orang anak atau 5,31% dari total jumlah populasi anak. Walaupun prevalensi balita stunting mencapai 12,58% dan masih dibawah angka Provinsi Jawa Tengah yaitu sebesar 14,51%, akan tetapi dengan adanya pandemi Covid-19 maka akan berdampak pada proses pelayanan kesehatan terutama terhadap ibu hamil di fasilitas kesehatan dan dibutuhkan kebijakan terkait hal tersebut. Kendalanya adalah ketidaksiapan ibu hamil menerima kebijakan pelayanan kesehatan yang diterapkan pada masa pandemi covid-19.
Vocabulary Instruction in Textbooks of Italian as a Foreign Language: A Descriptive Analysis
Authors: Concu Valentina , Noli Sara 
Published: March 2024

Abstract
Research in second language acquisition has shown that vocabulary growth is beneficial for reading (Qian 1999, 2000), listening comprehension (Staehr 2009), and has a positive influence on writing and speaking performances (Johnson et al. 2016; Levelt 1995). Vocabulary learning is hence a central pillar in the second language classroom. The activities used to enable the acquisition of new vocabulary play a crucial role in the learners’ path to proficiency. In this regard, the textbooks used are important since they can largely influence what types of vocabulary activities are used by the teachers in the classroom (Allen 2008; Tavakoli and Wright 2020; Woodward 1989). Nation (2013) provides a useful framework to analyze such activities. He identifies four strands that should be used in a balanced way to provide students with a comprehensive variety of tools to learn and apply new vocabulary. This study explores to what extent the four strands of activities are present in mainstream textbooks of Italian as a Foreign Language. This study also bridges a gap in the literature, since little research on vocabulary instruction has been done on the textbooks used for languages other than English. The result of our analysis shows that the Italian textbooks mostly focus on vocabulary aspects such as form-meaning mapping and grammar, leaving less room for meaning focused input and output. Furthermore, no activities that aimed at fluency development were found.
Combined International Trade and Investment Data “CITID” – A New Innovative and Comprehensive Data Landscape for Germany
Authors: Boddin Dominik , Kruse Hendrik W. , Merkle Hariolf , Walter Susanne , Zapf Benedikt 
Published: March 2024

Abstract
The Combined International Trade and Investment Data (CITID) represents a new innovative and comprehensive data landscape that combines firm-level data focused on international trade and investment. The datasets are sourced from both the Deutsche Bundesbank and the Federal Statistical Office of Germany, ensuring a reliable and robust data landscape. Within the CITID, multiple individual datasets seamlessly merge, encompassing a wide range of information. These include data on trade in goods, trade in services, inward and outward foreign direct investment (FDI), as well as information on international financial and capital transactions along with additional firm-level data. The data enables a holistic understanding of firms’ international integration, previously unattainable, and offers new opportunities for analyzing global trade dynamics. The data will be accessible for research. This paper provides a comprehensive description of the individual datasets, including information about their combinability, the methodology for matching them, the data’s content, and its potential for further research.