bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical study, network pharmacology, and molecular docking of Kunxian capsule in treating idiopathic membranous nephropathy
Authors: Lv Jia , Gao Xinyu , Liu Lihua , He Libing , Tian Geng , Lu Xuehong 
Published: February 2025

ObjectiveA new Tripterygium wilfordii preparation called Kunxian capsule (KX) has been approved in China. However, it is still unknown whether KX is safe and effective for idiopathic membranous nephropathy (IMN) and its therapeutic mechanism of action is unclear.MethodsWe conducted a retrospective study of 39 patients with IMN who received KX to investigate its efficacy and side effects of KX in treating IMN. We also used network pharmacology and molecular docking methods to explore the potential mechanism of action of KX in IMN.ResultsIn patients with IMN receiving KX treatment, 24 h urine protein was markedly decreased, whereas serum albumin levels increased. The overall clinical response rate was 79.49% after 6 months of treatment, and there were no significant adverse events. Quercetin, luteolin and kaempferol were the main bioactive ingredients of KX in treating IMN. AKT1, IL6, and TNF were core targets. The main potential mechanism of KX in treating IMN were pathways involved in cancer, the AGE-RAGE signaling pathway in diabetic complications, lipid and atherosclerosis. Molecular docking results showed that the binding force between the active ingredient and core target was relatively stable.ConclusionKX is a safe and effective treatment option for IMN and can effectively improve serum albumin and 24 h urine protein levels in patients with IMN. This study preliminarily reveals the possible mechanism of KX in the treatment of IMN and provides a theoretical basis for future clinical research.
Impact of underweight status on mortality in sepsis patients: a meta-analysis
Authors: Chen Jiaan , Zhang Fan , Liang Li , Pan Xuming , Zhang Jiancheng , Jin Guangjun 
Published: February 2025

ObjectiveThe evidence regarding the impact of underweight status on clinical outcomes in patients with sepsis are still scarce and controversial. We aimed at conducting a meta-analysis to evaluate the potential associations between underweight and the mortality rate among sepsis patients.MethodsA comprehensive electronic search was performed in PubMed, Cochrane Library, Embase, and Web of Science databases. Odds ratios (ORs) or mean differences and 95% confidence intervals (CIs) were calculated using RevMan 5.3.ResultsA total of 58,348 patients (normal weight group: 49,084 patients; underweight group: 9,264 patients) from 23 studies were included in this meta-analysis. The results indicated that the in-hospital mortality (OR, 1.28; 95% CI, 1.21, 1.35; heterogeneity: I2 = 21%, P = 0.21), 28-day mortality (OR, 1.54; 95% CI, 1.26, 1.88; heterogeneity: I2 = 74%, P &lt; 0.0001) and 1-year mortality (OR, 1.78; 95% CI, 1.58, 2.00; heterogeneity: I2 = 41%, P = 0.17) of underweight patients were significantly higher than those of normal weight patients. However, there was no significant difference in length of hospital stay or intensive care unit length of stay between underweight patients and normal-weight patients.ConclusionUnderweight is associated with increased mortality in patients with sepsis. Physicians should pay more attention to the management of underweight sepsis patients.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=631417, identifier CRD42025631417.
Cross-sectional association between plasma aldosterone concentration and cognitive performance by mini-mental state examination in community dwellers
Authors: Nusufujiang Aketilieke , Heizhati Mulalibieke , Li Nanfang , Yao Ling , Yang Wenbo , Wang Hui , Li Mei , Gan Lin , Maitituersun Adalaiti , Liu Miaomiao , Nuermaimaiti Qiaolifanayi , Cai Li , Aierken Xiayire , Li Xiufang , Luo Qin , Hong Jing 
Published: February 2025

BackgroundAldosterone is the effector hormone in the renin angiotensin aldosterone system and existing data suggest aldosterone affect cognitive function. However, the relationship between plasma aldosterone concentration (PAC) and cognitive performance remains unexplored in community dwellers. Therefore, we aimed to explore whether PAC is associated with cognitive performance in this population.MethodsWe cross-sectionally enrolled adults using multistage random sampling from Emin, China in 2019. Participants underwent questionnaires and data collection. Cognitive status was assessed using mini-mental state examination (MMSE) questionnaire. Multi-variable linear and logistic regression were used to explore the association between log PAC and log MMSE score, and between tertiled PAC (the higher PAC as the exposure) and low cognitive performance, respectively, in total, apparently healthy and diseased participants. Subgroup analyses also were performed by age, gender, BMI, living region, ethnicity and education attainment status.Results27,707 subjects were included, of whom, 12,862 were apparently healthy and 14,845 had disease. Log-PAC was positively associated with log-MMSE score in the multivariable linear regression in the total (B = 0.01, 95%CI: 0–0.01, p &lt; 0.001), apparently healthy (B = 0.01, 95%CI: 0–0.01, p = 0.007) participants, and the diseased without taking medicine (B = 0.01, 95%CI: 0.01–0.02, p = 0.004) participants. In logistic regression, the highest third tertile of PAC group showed significantly lower odds for the presence of low cognitive performance in total (OR = 0.83, 95%CI: 0.73–0.93, p = 0.002) and diseased without taking medicine participants (OR = 0.70, 95%CI: 0.57–0.86, p &lt; 0.001). Various sub-group analysis showed largely consistent results with the main analysis.ConclusionThere was a positive correlation between plasma aldosterone and cognitive functions in community dwellers, whereas further studies are need when considering the cross-sectional nature of the current study.
Malícia honey (Mimosa quadrivalvis L.) produced by the jandaíra bee (Melipona subnitida D.) shows antioxidant activity via phenolic compound action in obese rats
Authors: Bezerra Maria Luiza Rolim , Gouveia-Nhanca Mirela , da Veiga Dutra Maria Letícia , Batista Kamila Sabino , de Araújo Alana Natalícia Vasconcelos , dos Santos Lima Marcos , Ribeiro Mateus Duarte , Silva Alexandre Sergio , Alves Adriano Francisco , Pimentel Tatiana Colombo , Magnani Marciane , de Souza Aquino Jailane 
Published: February 2025

Background and aimsObesity is a disease associated with increased oxidative stress in humans and animals, and consumption of antioxidant compounds such as polyphenols can minimise it. These compounds are abundant in malícia (Mimosa quadrivalvis L.) honey produced by stingless bees. This study aimed to evaluate whether administration of Mimosa quadrivalvis L. honey to obese rats could reduce oxidative stress in vital organs through phenolic compound action.MethodsWistar rats (228 ± 14.69 g) were randomly divided into two groups: a healthy group (HG, n = 20) fed a control diet and an obese group (OG, n = 20) fed a cafeteria diet for the initial 8 weeks. After this period, these groups were again randomised into four subgroups: healthy (HG, n = 10), obese (OG, n = 10), healthy with malícia honey administration (1,000 mg/kg; HGH, n = 10), and obese with malícia honey administration (1,000 mg/kg; OGH, n = 10) for the final 8 weeks fed the previously mentioned diets. The rats were euthanised at the end of the experiment to collect brain, gut, kidney, and liver tissues to evaluate parameters related to oxidative stress and phenolic profile.ResultsThe administration of malícia honey reduced energy intake and weight gain in the OGH in comparison to the OG. Total antioxidant capacity increased in the brain, liver, and gut in both groups treated with honey compared to respective controls. Lipid peroxidation decreased in the brain, gut, and kidney of the OGH. Both treated groups showed elevated phenolic compound deposition, including catechin, procyanidins, and flavonoids, across all organs. Specifically, the brain in the OGH showed greater procyanidin B2 and gallic acid deposition; the liver showed increased procyanidin B1 and B2, epicatechin, and myricetin concentrations; the gut showed higher procyanidin B2 and kaempferol 3-glucoside concentrations; and the kidneys had increased catechin, procyanidin B1 and B2, and gallic acid deposition compared to the OG.ConclusionHistologically, the OGH displayed reduced neuronal damage and prevention of hepatic steatosis induced by the cafeteria diet. Malícia honey effectively reduced oxidative stress via modulation of phenolic compounds in the brain, gut, kidney, and liver of cafeteria diet-induced obese rats.
Research progress of MRI-based radiomics in hepatocellular carcinoma
Authors: Xie Xiao-Yun , Chen Rong 
Published: February 2025

BackgroundPrimary liver cancer (PLC), notably hepatocellular carcinoma (HCC), stands as a formidable global health challenge, ranking as the sixth most prevalent malignant tumor and the third leading cause of cancer-related deaths. HCC presents a daunting clinical landscape characterized by nonspecific early symptoms and late-stage detection, contributing to its poor prognosis. Moreover, the limited efficacy of existing treatments and high recurrence rates post-surgery compound the challenges in managing this disease. While histopathologic examination remains the cornerstone for HCC diagnosis, its utility in guiding preoperative decisions is constrained. Radiomics, an emerging field, harnesses high-throughput imaging data, encompassing shape, texture, and intensity features, alongside clinical parameters, to elucidate disease characteristics through advanced computational techniques such as machine learning and statistical modeling. MRI radiomics specifically holds significant importance in the diagnosis and treatment of hepatocellular carcinoma (HCC).ObjectiveThis study aims to evaluate the methodology of radiomics and delineate the clinical advancements facilitated by MRI-based radiomics in the realm of hepatocellular carcinoma diagnosis and treatment.MethodsA systematic review of the literature was conducted, encompassing peer-reviewed articles published between July 2018 and Jan 2025, sourced from PubMed and Google Scholar. Key search terms included Hepatocellular carcinoma, HCC, Liver cancer, Magnetic resonance imaging, MRI, radiomics, deep learning, machine learning, and artificial intelligence.ResultsA comprehensive analysis of 93 articles underscores the efficacy of MRI radiomics, a noninvasive imaging analysis modality, across various facets of HCC management. These encompass tumor differentiation, subtype classification, histopathological grading, prediction of microvascular invasion (MVI), assessment of treatment response, early recurrence prognostication, and metastasis prediction.ConclusionMRI radiomics emerges as a promising adjunctive tool for early HCC detection and personalized preoperative decision-making, with the overarching goal of optimizing patient outcomes. Nevertheless, the current lack of interpretability within the field underscores the imperative for continued research and validation efforts.
Evaluation of patient immunocompetence for immune checkpoint inhibitor therapy using the psoas muscle index: a retrospective cohort study
Authors: Tsurui Toshiaki , Hamada Kazuyuki , Mura Emiko , Suzuki Risako , Iriguchi Nana , Ishiguro Tomoyuki , Hirasawa Yuya , Ohkuma Ryotaro , Shimokawa Masahiro , Ariizumi Hirotsugu , Kubota Yutaro , Horiike Atsushi , Wada Satoshi , Yoshimura Kiyoshi , Tsuji Mayumi , Kiuchi Yuji , Tsunoda Takuya 
Published: February 2025

IntroductionIn patients with cancer, sarcopenia is an indicator of poor prognosis and is associated with an increased risk of chemotherapy-related adverse events. Skeletal muscle interacts with the immune system, and sarcopenia is associated with immune senescence. However, the association between sarcopenia and the response to immune checkpoint inhibitor (ICI) therapy remains unclear.MethodsThis retrospective study included patients with advanced or recurrent non-small cell lung cancer treated with nivolumab or pembrolizumab monotherapy. The association between the psoas muscle index (PMI) and both clinical response and immune-related adverse events (irAEs) was assessed using logistic regression. The PMI was calculated as the cross-sectional area of the psoas muscle divided by the square of the height based on computed tomography scans performed before the initial administration of ICI therapy.ResultsA total of 67 patients were included in the analysis. Logistic regression analysis showed that PMI was associated with the overall response (odds ratio [OR]: 1.52; 95% confidence interval [CI]: 1.04–2.22; p = 0.030) and the risk of severe irAEs (OR: 1.72; 95% CI: 1.05–2.80; p = 0.031).ConclusionThese findings suggest that PMI is both an indicator of prognosis and a surrogate marker of immunocompetence in predicting the clinical response to ICI therapy.
Esophageal submucosal gland duct adenoma: a case report and literature review
Authors: Zhou Bing , Zheng Jian , Huang Ling , Hao Hua 
Published: February 2025

IntroductionEsophageal submucosal gland duct adenoma (ESGDA) is a rare, benign tumor with non-specific clinical features and imaging findings, often leading to misdiagnosis.Case reportIn this report we describe the clinicopathological features of a new-onset case of ESGDA and review 19 previously-reported ESGDA cases in the literature.ResultsThe median age of the 20 patients was 70 years, and the male-to-female ratio was 5:2. Lesions located in the lower esophagus accounted for 81% of the cases. Chest and abdominal discomfort were the main clinical symptoms, and endoscopic findings mostly included polypoid masses that were impossible to correctly diagnose prior to excision and biopsy. On microscopic examination, the submucosal tumor was found to be composed of glandular cavities of various sizes, bland cytology with infrequent mitotic figures, and the interstitium was infiltrated by a large number of lymphocytes. Immunohistochemical analysis revealed the expression of adenomyoepithelial cytokeratins (CK) CK7, CK5/6, and p63. Local tumor resection was performed, the longest follow-up period was 132 months of the 20 patients, the prognosis was favorable, and no recurrence or metastasis.DiscussionESGDA is more common in the lower esophagus in elderly patients, and its clinical symptoms are atypical. Taking into account its characteristic microscopic morphology and immunohistochemical markers, the possibility of this rare disease should be considered to avoid misdiagnosis or missed diagnosis. Complete en bloc resection with Endoscopicp may be the best strategy for both the diagnosis and treatment of this entity.
The impact of integrated genomic analysis on molecular classifications and prognostic risk stratification in endometrial cancer: a Chinese experience
Authors: Zheng Qian , Shao Di , Shu Jin , Zhang Qin , Huang Min , Wang Dong , Zou Dongling 
Published: February 2025

BackgroundThe molecular classification of endometrial cancer (EC), as proposed by The Cancer Genome Atlas (TCGA), has transformed tumor classification, but there is a lack of extensive research on the molecular profiles and subtyping of endometrial cancer patients in China.Methods200 EC patients were classified into the following four molecular types: (i) POLEmut; (ii) MSI-H; (iii) TP53mut; (iv) NSMP. This study aimed to investigate the molecular characteristics of EC patients at a single center by large-scale next generation sequencing(NGS), including clinicopathological features and gene mutations in patients with distinct molecular types, and to assess the relevance of molecular subtyping for postoperative adjuvant therapy.ResultsNSMP group was the most prevalent, comprising 46.0% (92/200) of cases, followed by the TP53mut group at 17.5% (35/200), the MSI-H group at 23.5% (47/200), and the POLEmut group at 13.0% (26/200). CTNNB1 mutations were common in the POLEmut group but rare in the TP53mut group. With the application of the new European Society for Medical Oncology (ESMO) 2022 classification, 27 patients (14.1%) were reclassified. Concordance between the two classifications regarding postoperative risk was observed in 85.9% (165/192) of cases. Seven patients (3.6%) were downstaged, and twenty patients (10.4%) were upgraded. Additionally, the analysis revealed that eleven genes were significantly mutated in patients with lymphovascular space invasion (LVSI) compared to those without LVSI. Notably, NSD3 and POLD1 were highly mutated in patients with lymphatic metastasis compared to those without lymphatic metastasis. Conclusively, large-scale NGS has revolutionized EC management by facilitating rapid molecular subtype identification, guiding tailored adjuvant therapies, targeted treatments, and immunotherapies, and efficiently screening for Lynch syndrome, thereby significantly improving patient outcomes.
The analgesic effects of quadratus lumborum block versus caudal block for pediatric patients undergoing abdominal surgery: a systematic review and meta-analysis
Authors: Zhu Yu , Wu Jin , Qu Shenglong , Jiang Peng , Bohara Chetan , Li Yi 
Published: February 2025

BackgroundSince children cannot express pain, postoperative pain treatment for them is relatively lacking. In this meta-analysis, we compared the postoperative analgesic effects of quadratus lumborum block (QLB) and caudal block (CB) in surgeries involving the lower abdomen, inguinal region, and urogenital system in children.ObjectiveThis review examined the postoperative analgesic effects of QLB and CB in pediatric patients (0–18 years of age) undergoing abdominal surgery. The primary endpoint was the rate of postoperative rescue analgesia, defined as the proportion of patients who returned to acetaminophen, ibuprofen, and other analgesics when the pain score was greater than the protocol preset value within 24 h after surgery. Secondary outcomes included resting pain scores (0–10) at 30 min, 4 h, 12 h, and 24 h after surgery. Other secondary outcome measures were the time of first rescue analgesia, the incidence of PONV, and the incidence of postoperative complications, such as post-block infection, anaphylaxis to local anesthesia and hematoma.Evidence reviewWe systematically reviewed Pubmed, Central, EMBASE, Google Scholar, Web of Science citation index, the US clinical trials register, and abstracts for randomized controlled trials that compared these blocks and reported the rate of postoperative rescue analgesia.FindingsSeven RCTs (444 patients) were included in the final analysis. In pediatric abdominal surgery, compared with CB, QLB could reduce the rate of postoperative rescue analgesia within 24 h after surgery (RR = 0.37; 95% CI = 0.26 to 0.51; P &lt; 0.01). The pain score in the QLB group at 4 (SMD = −0.11; 95% CI = −0.21 to −0.01; P = 0.02) and 12 h (SMD = −0.11; 95% CI = −0.22 to 0.00; P = 0.06) after surgery was lower, but at 0.5(SMD = 0.42; 95% CI = 0.34 to 0.50; P &lt; 0.01) and 24 h (SMD = 0.30; 95% CI = 0.03 to 0.58; P = 0.03) was higher than that in the CB group. Of note, these pain score differences were not clinically significant. In addition, there was no significant difference in the incidence of complications or side effects between the QLB and the CB group (RR = 0.94; 95% CI = 0.59 to 1.48; P = 0.77).ConclusionIn conclusion, QLB might have a better postoperative analgesic effect for lower abdominal surgery than CB in pediatric patients. However, due to the relatively few RCTs identified and significant heterogeneity, further research in the future is needed to prove these findings.Systematic Review Registrationidentifier (CRD 42023441447).
Therapeutic potential of cannabinoids in neurological conditions: a systematic review of clinical trials
Authors: Hakami Alqassem Y. , Alshehri Fahad S. 
Published: February 2025

OverviewCannabinoids have gained increasing attention for their therapeutic potential in treating several neurological conditions, including neurodegenerative diseases, chronic pain, and epilepsy. This review aims to assess the current clinical trials investigating cannabinoids, primarily Tetrahydrocannabinol and Cannabidiol, for neurological disorders. This review will aim to highlight the efficacy, safety, and outcome measures used in these trials.MethodsClinical trials were identified using ClinicalTrials.gov, focusing on studies that examined the effects of cannabinoids in treating neurological conditions. All trials that fulfilled the following criteria were included: Phase 1–4, focused on cannabinoids as primary intervention, and measured relevant outcomes such as pain relief, cognitive function, or spasticity reduction. Data on conditions, interventions, primary and secondary outcomes, and trial phases were extracted and analysed.ResultsA total of 47 clinical trials were identified, including different neurological conditions. The most frequently studied conditions were Multiple Sclerosis, Fibromyalgia, and Parkinson’s Disease. Most trials were in Phase 2, with the primary outcome measures focused on pain management, spasticity, and cognitive function. Secondary outcomes included safety and tolerability measures.ConclusionThe review highlights the broad therapeutic potential of cannabinoids in neurology, with promising results in symptom management for conditions like Multiple Sclerosis and Fibromyalgia. However, the lack of standardized study protocols, dosing, and outcome measures presents challenges for broader clinical implementation.Systematic Review Registrationclinicatrials.gov.
Data-driven nitrogen application for satinleaf: leveraging optical sensors in urban landscape management
Authors: Nogueira Souza Costa Bárbara , Khoddamzadeh Amir Ali 
Published: February 2025

The use of sensor technology is essential in managing fertilization, especially in urban landscape where excessive fertilization is a common issue that can lead to environmental damage and increased costs. This study focused on optimizing nitrogen fertilizer application for Satinleaf (Chrysophyllum oliviforme), a native Florida plant commonly used in South Florida landscaping. Fertilizer with an 8N-3P-9K formulation was applied in six different treatments: 15 g (control), 15 g (15 g twice; T1), 15 g (15 g once; T2), 30 g (15 g twice; T3), 30 g (15 g once; T4), and 45 g (15 g twice; T5). Evaluations of plant growth and nutrient status were conducted at several intervals: baseline (0), and 30, 60, 90, 120, 150, and 180 days post-fertilizer application. Three types of optical sensors-GreenSeeker™, SPAD meter, and atLEAF chlorophyll sensor - were used to monitor chlorophyll levels as an indicator of nitrogen content. The study found that the 30 g (15 g twice; T3) treatment was most effective in promoting plant growth and increasing nitrogen content in leaves and soil, while the 45 g (15 g twice; T5) treatment resulted in higher nutrient runoff, indicating potential environmental risks. These findings emphasize the value of using optical sensors for precise nitrogen management in plant nurseries to enhance growth, lower costs, and minimize environmental impact.