bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mid-term results of cementless total hip replacement using a ceramic-on-ceramic bearing with and without computer navigation
Authors: Sugano N. , Nishii T. , Miki H. , Yoshikawa H. , Sato Y. , Tamura S. 
Published: April 2007

We have developed a CT-based navigation system using infrared light-emitting diode markers and an optical camera. We used this system to perform cementless total hip replacement using a ceramic-on-ceramic bearing couple in 53 patients (60 hips) between 1998 and 2001. We reviewed 52 patients (59 hips) at a mean of six years (5 to 8) postoperatively. The mid-term results of total hip replacement using navigation were compared with those of 91 patients (111 hips) who underwent this procedure using the same implants, during the same period, without navigation. There were no significant differences in age, gender, diagnosis, height, weight, body mass index, or pre-operative clinical score between the two groups. The operation time was significantly longer where navigation was used, but there was no significant difference in blood loss or navigation-related complications. With navigation, the acetabular components were placed within the safe zone defined by Lewinnek, while without, 31 of the 111 components were placed outside this zone. There was no significant difference in the Merle d’Aubigne and Postel hip score at the final follow-up. However, hips treated without navigation had a higher rate of dislocation. Revision was performed in two cases undertaken without navigation, one for aseptic acetabular loosening and one for fracture of a ceramic liner, both of which showed evidence of neck impingement on the liner. A further five cases undertaken without navigation showed erosion of the posterior aspect of the neck of the femoral component on the lateral radiographs. These seven impingement-related mechanical problems correlated with malorientation of the acetabular component. There were no such mechanical problems in the navigated group. We conclude that CT-based navigation increased the precision of orientation of the acetabular component and control of limb length in total hip replacement, without navigation-related complications. It also reduced the rate of dislocation and mechanical problems related to impingement.
Mortality and mobility after hip fracture in Japan
Authors: Tsuboi M. , Hasegawa Y. , Suzuki S. , Wingstrand H. , Thorngren K.-G. 
Published: April 2007

We studied prospectively the change over ten years in mortality, walking ability and place of residence after a hip fracture in 753 patients in Japan. We compared the deaths observed in these patients with those expected in the general population, matched for age, gender and calender year at the time of fracture. The survival rate decreased dramatically for two years after the event and the mortality risk remained higher for ten years. This risk was approximately double that of the general population, even at ten years after fracture. The risk was higher, and remained so for longer, in younger rather than in older patients. The proportion of patients who were able to walk outdoors alone, with or without an assistive device, was 68% (514) before fracture. This decreased to 56% (340) by one year after and remained stable at approximately 63% (125) until ten years. The proportion of patients living in their own home was 84% (629) before fracture, 81% (491) one year later, and then remained stable at approximately 86% (171) until ten years after the event.
Natural History of Hyperplastic Callus Formation in Osteogenesis Imperfecta Type V
Authors: Cheung Moira S , Glorieux Francis H , Rauch Frank 
Published: April 2007

Abstract
Hyperplastic callus formation was assessed in 23 patients with osteogenesis imperfecta type V. Hyperplastic callus mostly affected long bones in the lower extremities and occurred predominantly during phases of rapid growth.
Introduction: Hyperplastic callus (HPC) formation is one of the most conspicuous features of osteogenesis imperfecta (OI) type V, but the natural history of HPC has not been well characterized.
Materials and Methods: In this retrospective single-center study, we assessed HPC in 23 OI type V patients (9 females and 14 males).
Results: Fifteen patients (65%) had HPC at 48 skeletal sites, 30 of which affected the lower limbs. The number of HPC sites per patient ranged from 0 to 7, with an average of 2.6 for men and 1.1 for women (p = 0.047 for this sex difference; t-test). New HPC formation was observed both after fractures and outside of the context of fractures. Only a minority of lower limb fractures (26%) precipitated HPC formation. After an initial enlargement phase, HPC lesions usually stabilized, but could also resolve completely (n = 2) or progress and lead to bone deformation. The most common complication of HPC was a fracture through the lesion (n = 7). Neither pamidronate nor indomethacin seemed to influence the course of HPC.
Conclusions: HPC is a potentially serious complication of OI type V. Given the rarity of the disorder, treatment studies will require multicenter collaborations.
Genetic Dissection of Mouse Distal Chromosome 1 Reveals Three Linked BMD QTLs With Sex-Dependent Regulation of Bone Phenotypes
Authors: Beamer Wesley G , Shultz Kathryn L , Ackert-Bicknell Cheryl L , Horton Lindsay G , Delahunty Krista M , Coombs Harold F , Donahue Leah R , Canalis Ernesto , Rosen Clifford J 
Published: April 2007

Abstract
Genetic analyses with mouse congenic strains for distal Chr1 have identified three closely linked QTLs regulating femoral vBMD, mid-diaphyseal cortical thickness, and trabecular microstructure in a sex-dependent fashion. The homologous relationship between distal mouse Chr 1 and human 1q21–24 offers the possibility of finding common regulatory genes for cortical and trabecular bone.
Introduction: The distal third of mouse chromosome 1 (Chr 1) has been shown to carry a major quantitative trait locus (QTL) for BMD from several inbred mouse strain crosses. Genetic and functional analyses are essential to identify genes and cellular mechanisms for acquisition of peak bone mass.
Materials and Methods: Nested congenic sublines of mice were developed with a C57BL/6J (B6) background carrying &lt;1- to 9-Mbp-sized segments donated from C3H/HeJ (C3H). Isolated femurs from 16-wk-old female and male mice were measured by pQCT and μCT40 for volumetric (v)BMD, mid-diaphyseal cortical thickness, and distal trabecular phenotypes. Static and dynamic histomorphologic data were obtained on selected females and males at 16 wk.
Results and Conclusions: We found that the original BMD QTL, Bmd5, mapped to distal Chr 1 consists of three QTLs with different effects on vBMD and trabecular bone in both sexes. Compared with B6 controls, femoral vBMD, BMD, and cortical thickness (p &lt; 0.0001) were significantly increased in congenic subline females, but not in males, carrying C3H alleles at QTL-1. Both females and males carrying C3H alleles at QTL-1 showed marked increases in BV/TV by μCT compared with B6 mice (p &lt; 0.0001). Females increased BV/TV by increasing trabecular thickness, whereas males increased trabecular number. In addition, the μCT40 data showed two unique QTLs for male trabecular bone, QTL-2 and QTL-3, which may interact to regulate trabecular thickness and number. These QTLs are closely linked with and proximal to QTL-1. The histomorphometric data revealed sex-specific differences in cellular and bone formation parameters. Mice and humans share genetic homology between distal mouse Chr 1 and human Chr 1q20–24 that is associated with adult human skeletal regulation. Sex- and compartment-specific regulatory QTLs in the mouse suggest the need to partition human data by sex to improve accuracy of mapping and genetic loci identification.
A Novel, High-Throughput Workflow for Discovery and Identification of Serum Carrier Protein-Bound Peptide Biomarker Candidates in Ovarian Cancer Samples
Authors: Lopez Mary F , Mikulskis Alvydas , Kuzdzal Scott , Golenko Eva , Petricoin Emanuel F , Liotta Lance A , Patton Wayne F , Whiteley Gordon R , Rosenblatt Kevin , Gurnani Prem , Nandi Animesh , Neill Samuel , Cullen Stuart , O’Gorman Martin , Sarracino David , Lynch Christopher , Johnson Andrew , Mckenzie William , Fishman David 
Published: April 2007

Abstract
Background: Most cases of ovarian cancer are detected at later stages when the 5-year survival is ∼15%, but 5-year survival approaches 90% when the cancer is detected early (stage I). To use mass spectrometry (MS) of serum proteins for early detection, a seamless workflow is needed that provides an opportunity for rapid profiling along with direct identification of the underpinning ions.
Methods: We used carrier protein–bound affinity enrichment of serum samples directly coupled with MALDI orthagonal TOF MS profiling to rapidly search for potential ion signatures that contained discriminatory power. These ions were subsequently directly subjected to tandem MS for sequence identification.
Results: We discovered several biomarker panels that enabled differentiation of stage I ovarian cancer from unaffected (age-matched) patients with no evidence of ovarian cancer, with positive results in &gt;93% of samples from patients with disease-negative results and in 97% of disease-free controls. The carrier protein–based approach identified additional protein fragments, many from low-abundance proteins or proteins not previously seen in serum.
Conclusions: This workflow system using a highly reproducible, high-resolution MALDI-TOF platform enables rapid enrichment and profiling of large numbers of clinical samples for discovery of ion signatures and integration of direct sequencing and identification of the ions without need for additional offline, time-consuming purification strategies.
Longitudinal Genetic Analysis for Loneliness in Dutch Twins
Authors: Boomsma Dorret I. , Cacioppo John T. , Muthén Bengt , Asparouhov Tihomir , Clark Shaunna 
Published: April 2007

AbstractIn previous studies we obtained evidence that variation in loneliness has a genetic component. Based on adult twin data, the heritability estimate for loneliness, which was assessed as an ordinal trait, was 48%. These analyses were done on loneliness scores averaged over items (‘I feel lonely’ and ‘Nobody loves me’) and over time points. In this article we present a longitudinal analysis of loneliness data assessed in 5 surveys (1991 through 2002) in Dutch twins (N = 8389) for the two separate items of the loneliness scale. From the longitudinal growth modeling it was found sufficient to have non-zero variance for the intercept only, while the other effects (linear, quadratic and cubic slope) had zero variance. For the item ‘I feel lonely’ we observed an increasing age trend up to age 30, followed by a decline to age 50. Heritability for individual differences in the intercept was estimated at 77%. For the item ‘Nobody loves me’ no significant trend over age was seen; the heritability of the intercept was estimated at 70%.
Can Genetic Factors Explain the Spillover of Warmth and Negativity Across Family Relationships?
Authors: Ganiban Jody M. , Spotts Erica L. , Lichtenstein Paul , Khera Gagan S. , Reiss David , Neiderhiser Jenae M. 
Published: April 2007

AbstractPrevious studies indicate that the emotional quality of marital relationships is mirrored in parent–child relationships. We explored the degree to which these associations are explained by genetic and environmental factors. Participants were drawn from the Twin and Offspring Study in Sweden (TOSS), and included 544 female twin pairs (258 monozygotic [MZ], 286 dizygotic [DZ]), and 311 male twin pairs (128 MZ, 183 DZ). The spouses and one adolescent child of each twin also participated in this study. The twins completed self-report measures that assessed their marital quality and their warmth and negativity towards their children. Observational ratings of marital warmth and negativity, and of maternal warmth and negativity were obtained for a subset of female twin pairs (150 MZ, 176 DZ). Selfreported marital satisfaction was associated with self-reported parental warmth and negativity for mothers (rs = .25, -.36) and fathers (rs = .25, -.44). For the observational measures, marital warmth was associated with maternal warmth (r = .42), while marital negativity was associated with maternal negativity (r = .34). On average genetic factors explained nearly half of the covariance between selfreported marital satisfaction and parenting for mothers (48%) and fathers (47%). Genetic factors explained 21% of the covariance between observed marital and maternal warmth, but did not contribute to associations between marital and maternal negativity. These findings indicate that parents' genetically influenced characteristics help shape the emotional climate of the family.
Changing Environmental Influences on Substance Use Across Development
Authors: Dick Danielle M. , Pagan Jason L. , Viken Richard , Purcell Shaun , Kaprio Jaakko , Pulkkinen Lea , Rose Richard J. 
Published: April 2007

AbstractIn contrast to many phenotypes that have been studied using twin designs, substance use shows considerable evidence of environmental influence. Accordingly, specifying the relevant environments and understanding the nature of their effects is an important research priority. Twin studies also have demonstrated that the importance of genetic and environmental influences varies across development for a variety of behavioral outcomes, including substance use. Here, we report analyses exploring moderating effects associated with parenting and peer characteristics on adolescent smoking and drinking, measured at ages 14 and 17. We find significant evidence of moderating effects associated with two dimensions of parenting (parental monitoring and time spent in activities with parents) on adolescent smoking, measured at two time points across development, but no moderating effects on adolescent drinking. Genetic influences on smoking increased, and common environmental effects decreased, as adolescents reported less parental monitoring and spending more time with their parents. Conversely, we find evidence that adolescent drinking is more strongly influenced by peer characteristics. The importance of genetic predispositions was increased among adolescents who reported more friends who used alcohol. These analyses illustrate the importance of incorporating measured aspects of the environment into genetically informative twin models to begin to understand how specific environments are related to various outcomes. Furthermore, they illustrate the importance of using a developmental perspective to understand how specific influences may vary across different ages, and across different phenotypes.
Genetic Regulation of Growth in Height and Weight from 3 to 12 Years of Age: A Longitudinal Study of Dutch Twin Children
Authors: Silventoinen Karri , Bartels Meike , Posthuma Daniëlle , Estourgie-van Burk G. Frederiek , Willemsen Gonneke , van Beijsterveldt Toos C. E. M. , Boomsma Dorret I. 
Published: April 2007

AbstractHuman growth is a complex and poorly understood process. We studied the effect of genetic and environmental factors on height and body mass index (BMI, kg/m2) based on maternal reports at 3, 4, 5, 7, 10 and 12 years of age in a large longitudinal cohort of Dutch twins (7755 complete twin pairs at age 3). Several multivariate variance component models for twins were fitted to the data using the Mx statistical package. The first-born twin was taller until age 10 and heavier until age 12 than the second-born co-twin. Heritability estimates were high for height (a2 = .58–.91) and BMI (a2 = .31–.82), but common and unshared environmental factors were also important. The phenotypic correlations across the ages for height and BMI were mainly explained by correlated additive genetic factors (ra = .77–.96 for height and .43–.92 for BMI), but common (rc = .40–.84 and .09–.78, respectively) and specific environmental correlations (re = .50–.81 and .42–.80, respectively) were also significant. Additive genetic factors decreased with increasing age difference for both height and BMI. However, the full Cholesky model, which does not make any assumptions regarding the underlying genetic structure, had the best fit. High genetic correlations across the ages, especially for height, may help further molecular genetic studies of human growth. Environmental factors affecting height and BMI during growth period are also important, and further studies are needed to identify these factors and test whether they interact with genetic factors.
Sex Differences and Heritability of Two Indices of Heart Rate Dynamics: A Twin Study
Authors: Snieder Harold , van Doornen Lorenz J. P. , Boomsma Dorret I. , Thayer Julian F. 
Published: April 2007

AbstractWe investigated whether women show larger heart rate variability (HRV) than men after controlling for a large number of health-related covariates, using two indices of HRV, namely respiratory sinus arrhythmia (RSA) and approximate entropy (ApEn). In a twin design, the heritability of both indices was examined. The covariation between RSA and ApEn, a measure of heart rate dynamics derived from nonlinear dynamical systems theory, was decomposed into genetic and environmental components. Subjects were 196 male and 210 female middle-aged twins. Females showed larger HRV than men before (ApEn: p < .001; RSA: p = .052) and after adjustment for covariates (ApEn: p < .001; RSA: p = .015). This sex difference was confirmed by significant intrapair differences in the opposite-sex twin pairs for both ApEn (p < .001) and RSA (p = .03). In addition to sex, only heart period and age (both p < .001) were found to be independent predictors of ApEn, whereas RSA was also influenced by respiration rate and smoking (both p < .001). Age explained 16% and 6% of the variance in RSA and ApEn, respectively. Oral contraceptive use and menopausal status had no effect on HRV. Genetic model fitting yielded moderate heritability estimates for RSA (30%) and ApEn (40%) for both males and females. The correlation between RSA and ApEn (r = .60) could be attributed to genetic factors (48%), environmental factors (36%) and age (16%). The present study found support for a gender difference in HRV with women having greater HRV than men even after controlling for a large number of potential confounders. Indices of heart rate dynamics derived from nonlinear dynamical systems theory are moderately heritable and may be more sensitive than traditional indices of HRV to reveal subtle sex differences with important implications for health and disease.
Regional Variations in Trends for Multiple Births: A Population-Based Evaluation in France, 1972–2003
Authors: Khoshnood Babak , Blondel Béatrice 
Published: April 2007

AbstractThe aim of the study was to assess, using population-based data, trends and regional variations in multiple births during the period of increasing use and changes in practice patterns for infertility treatments. National data for 24,554,977 births (live births and stillbirths) were used, including 569,423 twins during the period 1972 to 2003, and 14,599 triplets for 1984 to 2003. Statistical analyses included age-adjusted hierarchical logistic regression models for twin births and separate analyses for triple, same-sex, and different-sex twin births. Due to confidentiality considerations, the only variable available for adjustment was maternal age. Regionallevel variations were estimated using median odds ratios based on random-intercept hierarchical logistic regression models. Overall, twin births increased from 18.1 per 1000 births (95% confidence interval [CI] 17.9–18.2) in 1972 to 1975 to 29.9 per 1000 (95% CI 29.7–30.1) in 2000 to 2003. Twin births increased progressively across all regions, whereas triple births reached a peak in the early 1990s and decreased thereafter. Trends for both twin and triple births varied significantly across regions. Both trends and regional variations were greater for different-sex as compared with same-sex twin births. Regional variations in the proportion of multiple births increased in the case of twin births and decreased for triple births. Differences in multiple births at the regional level in France were comparable to country-level differences observed across several western and northern European countries. Regional differences in multiple births need to be monitored and used to inform policies aimed at regulating the use of infertility treatments.
Imaginary cartographies: race and new world borders
Authors: Mojica Martha Patricia Nio 
Published: April 2007

Mobile technologies and networks facilitate the delocalization of traditional power structures within an economic frame. This shift usually incorporates the discourse of the body creation as well. Our bodies are constructs in which individuals as well as and social perceptions and projections,
reality and fiction fuse together. In a similar way, we doubt about the representation of reality and highly editable and generative images.
Nonetheless, some forms of bio-power can be identified in contemporary constructed mental images such as race or ethnicity usually linked to religious
or linguistic differences that are traditionally used as borderline zones. Many examples can be traced back to representations of both fauna and populations of the new world in colonial America. This phenomenon has also emerged in representations of cyberspace even though Internet is advertised
as a place in which traditional distinctions and imbalances in power between individuals have been effaced.
If Zizek's statement is true that in order to capture the spirit of an age you should not look to explicit social structures but rather to the ghosts that haunt us, and live in a
region of nonexistent entities, the topic of globalization should not put aside issues of immigration and multiple representations of race. This situation is inherent to the present and future construction of both cyberspace and public physical space. Media imaginaries create a myriad of information
that also includes artificial savages. This fact constitutes what some artists provocatively call a rather explosive universe of cultural misunderstanding under a new world border.
Brief notes on two inf inite scales
Authors: Furtado Gonalo 
Published: April 2007

This text includes a series of considerations which were detailed during the event1 organized in 2006 by Emanuel Dimas Pimenta, on the subject of The Spirit of Discovery.
These considerations relate to the present situation of contemporary architecture, which has gradually been marked
first by the phenomenon of digital information and, more recently, by a biotechnological vision. Although the influence of the former has been firmly established, the latter serves as the inspiration for a mutant generative architecture, and leads us to consider the interface between body,
technology and space. Initially this text points out the cultural interference and spatial resonance of the well-established Information Society, reflecting the current life of an urban-architectural space marked by the omnipresence of networks and informational-digital phenomena. Subsequently,
the minute scale of the interface and the interaction between the body and technological space become critical questions. On a larger scale, complex, self-organizational dynamics will come to dominate our understanding of the meta-territory of the future. Therefore, the contemporary condition
suggests the need for a dialogue between the infinitely large and the infinitely small, within a spirit of discovery regulated by the incompleteness of knowledge within a Godelian consciousness.