bluuebunny/crossref_metadata_2025_split huggingface dataset:
Students’ perceptions of storytelling online class at the English Education Department
Authors: Amrillah Asep , Fatimah Nur , Afriandi Muhamad Argi 
Published: March 2024

Due to Covid-19, virtual learning at all education levels has been implemented. Storytelling is one of the courses conducted online. The aim of this study is to find out the students’ perceptions on the importance of storytelling, the tasks in an online class of storytelling, and the advantages of learning outcome of online storytelling.
This research is qualitative. The data were collected from a storytelling class in an English Education Department in Yogyakarta. They were obtained from an open-ended question questionnaire and interview with 22 students who have attended in storytelling online class.
The results show that the students have positive perceptions on storytelling in language teaching. Two of the tasks supporting the storytelling are students’ video recording for storytelling and creating new stories. In relation to the learning outcome, the students’ views that it is advantageous to enhance speaking skills and it results in the learning product such as a story book. This study can be taken into account to improve quality, policies, and program development in English Education Department.
Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG)
Authors: Kostka Julia , Maharjan Anu S. , Kumar Sanjai , Hackenyos Douglas , Krause Peter J. , Dieckhaus Kevin 
Published: March 2024

Background
Babesiosis is a worldwide emerging protozoan infection that is associated with a spectrum of disease severity from asymptomatic infection to severe organ damage and death. While effective treatment strategies are available, some immunocompromised patients experience severe acute and prolonged/relapsing illness due in part to an impaired host antibody response. Intravenous immunoglobulin (IVIG) has been used as an adjunctive therapy in some immunocompromised babesiosis patients, but its therapeutic effect is uncertain. We evaluated the presence of Babesia microti antibodies in commercial samples of IVIG.

Methods/principle findings
The presence of B. microti antibodies in commercial samples of IVIG were tested using an immunofluorescence assay. A subset of samples was then tested for B. microti antibodies using an enzyme linked immunosorbent assay.
Out of 57 commercial IVIG samples tested using IFA, and 52 samples tested using ELISA, none were positive for B. microti antibodies.

Conclusions
Commercially available IVIG may not be of therapeutic benefit for babesiosis patients. Additional sampling of IVIG for B. microti antibody and a clinical trial of babesiosis patients given IVIG compared with controls would provide further insight into the use of IVIG for the treatment of babesiosis.
Phenolic compounds of Theobroma cacao L. show potential against dengue RdRp protease enzyme inhibition by In-silico docking, DFT study, MD simulation and MMGBSA calculation
Authors: Huq A. K. M. Moyeenul , Roney Miah , Dubey Amit , Nasir Muhammad Hassan , Tufail Aisha , Aluwi Mohd Fadhlizil Fasihi Mohd , Ishak Wan Maznah Wan , Islam Md. Rabiul , Tajuddin Saiful Nizam 
Published: March 2024

BackgroundCurrently, there is no antiviral medication for dengue, a potentially fatal tropical infectious illness spread by two mosquito species,Aedes aegyptiandAedes albopictus. The RdRp protease of dengue virus is a potential therapeutic target. This study focused on the in silico drug discovery of RdRp protease inhibitors.MethodsTo assess the potential inhibitory activity of 29 phenolic acids from Theobroma cacao L. against DENV3-NS5 RdRp, a range of computational methods were employed. These included docking, drug-likeness analysis, ADMET prediction, density functional theory (DFT) calculations, and molecular dynamics (MD) simulations. The aim of these studies was to confirm the stability of the ligand-protein complex and the binding pose identified during the docking experiment.ResultsTwenty-one compounds were found to have possible inhibitory activities against DENV according to the docking data, and they had a binding affinity of ≥-37.417 kcal/mol for DENV3- enzyme as compared to the reference compound panduratin A. Additionally, the drug-likeness investigation produced four hit compounds that were subjected to ADMET screening to obtain the lead compound, catechin. Based on ELUMO, EHOMO, and band energy gap, the DFT calculations showed strong electronegetivity, favouravle global softness and chemical reactivity with considerable intra-molecular charge transfer between electron-donor to electron-acceptor groups for catechin. The MD simulation result also demonstrated favourable RMSD, RMSF, SASA and H-bonds in at the binding pocket of DENV3-NS5 RdRp for catechin as compared to panduratin A.ConclusionAccording to the present findings, catechin showed high binding affinity and sufficient drug-like properties with the appropriate ADMET profiles. Moreover, DFT and MD studies further supported the drug-like action of catechin as a potential therapeutic candidate. Therefore, furtherin vitroandin vivoresearch on cocoa and its phytochemical catechin should be taken into consideration to develop as a potential DENV inhibitor.
Análisis de las importaciones oleícolas hispanas en la Carthago romana a partir del estudio de las marcas epigráficas sobre ánforas del tipo Dressel 20
Authors: Colom Mendoza Enric 
Published: March 2024

El hallazgo de ánforas béticas del tipo Dressel 20 no es muy común en las excavaciones arqueológicas realizadas en Carthago romana. De un total de más de 500 individuos anfóricos romanos catalogados en el Musée National de Carthage, sólo 13 fragmentos de asa pertenecen al tipo Dressel 20, de los cuales sólo cuatro pueden ser atribuidos a un contexto arqueológico claro, que son los niveles de destrucción provocados sobre la necrópolis púnica de Bordj-Djedid, situada en la ladera norte de la ciudad.
Pese a esta acuciante falta de datos para esta importante ciudad africana, el análisis pormenorizado de estas evidencias, inéditas hasta día de hoy, nos permitirá añadir un eslabón en el estado del conocimiento de las relaciones comerciales con el norte de África, así como dilucidar el papel de la ciudad de Carthago en relación con la importación de productos oleícolas. Igualmente, a partir de los hallazgos documentados, podremos lanzar una serie de hipótesis sobre su posible rol en la redistribución de las ánforas Dressel 20 hasta los puertos situados en los confines del Mediterráneo oriental.
Limited Sustained Remission After Nucleos(t)ide Analog Withdrawal: Results From a Large, Global, Multiethnic Cohort of Patients With Chronic Hepatitis B (RETRACT-B Study)
Authors: Hirode Grishma , Hansen Bettina E. , Chen Chien-Hung , Su Tung-Hung , Wong Grace L.H. , Seto Wai-Kay , d'Almeida Arno Furquim , Papatheodoridi Margarita , Brakenhoff Sylvia M. , Lens Sabela , Choi Hannah S.J. , Chien Rong-Nan , Feld Jordan J. , Forns Xavier , Sonneveld Milan J. , Papatheodoridis George V. , Vanwolleghem Thomas , Yuen Man-Fung , Chan Henry L.Y. , Kao Jia-Horng , Hsu Yao-Chun , Cornberg Markus , Jeng Wen-Juei , Janssen Harry L.A. ,   on behalf of the RETRACT-B study group
Published: March 2024

INTRODUCTION:
Complete viral suppression with nucleos(t)ide analogs (NAs) has led to a profound reduction in hepatocellular carcinoma and mortality among patients with chronic hepatitis B. Finite therapy yields higher rates of functional cure; however, initial hepatitis B virus (HBV) DNA and alanine aminotransferase (ALT) elevations are almost certain after treatment interruption. We aimed to analyze off-treatment outcomes beyond 12 months after NA cessation.

METHODS:
Patients with well-suppressed chronic hepatitis B who were hepatitis B e antigen-negative at NA cessation and remained off treatment without hepatitis B surface antigen (HBsAg) loss at 12 months were included (n = 945). HBV DNA and ALT fluctuations were allowed within the first 12 months. We used Kaplan-Meier methods to analyze outcomes beyond 12 months. Sustained remission was defined as HBV DNA <2,000 IU/mL and ALT <2× upper limit of normal (ULN) and an ALT flare as ALT ≥5× ULN.

RESULTS:
Cumulative probability of sustained remission was 29.7%, virological relapse was 65.2% with a mean peak HBV DNA of 5.0 ± 1.5 log10 IU/mL, an ALT flare was 15.6% with a median peak ALT × ULN of 8.3 (5.7–11.3), HBsAg loss was 9.9% and retreatment was 34.9% at 48 months after NA cessation. A single occurrence of virological relapse or an ALT flare within the first 12 months off-treatment were associated with significantly lower rates of sustained remission beyond 12 months.

DISCUSSION:
Despite allowing for HBV DNA and ALT fluctuations within the first 12 months off-treatment, most patients without HBsAg loss did not maintain a sustained response thereafter. The best candidates for NA withdrawal are patients with low HBsAg levels at NA cessation, and those without profound or recurrent virological and biochemical relapses in the first off-treatment year.
Evaluating the association between opium abuse, blood lead levels, and the complexity of coronary artery disease
Authors: Khameneh Bagheri Ramin , Mousavi Seyed Hadi , Mehrad‐Majd Hassan , Jamili Mohammad Javad , Nasimi Shad Arya , Baradaran Rahimi Vafa 
Published: March 2024

AbstractOpium abuse and exposure to heavy metals elevate the risk of coronary artery disease (CAD). Therefore, we aimed to determine the association between opium abuse and blood lead levels (BLLs) and the CAD complexity. We evaluated patients with acute coronary symptoms who underwent coronary angiography, and those with >50% stenosis in at least one of the coronary arteries were included. Furthermore, Synergy between PCI with Taxus and Cardiac Surgery I (SYNTAX I) score and BLLs were measured. Based on the opium abuse, 95 patients were subdivided into opium (45) and control (50) groups. Differences in demographics and CAD risk factors were insignificant between the two groups. The median BLLs were remarkably higher in the opium group than in controls (36 (35.7) and 20.5 μg/dL (11.45), respectively, p = 0.003). We also revealed no significant differences in SYNTAX score between the two groups (15.0 (9.0) and 17.5 (14.0), respectively, p = 0.28). Additionally, we found no significant correlation between BLLs and the SYNTAX scores (p = 0.277 and r = −0.113). Opium abuse was associated with high BLLs. Neither opium abuse nor high BLLs were correlated with the complexity of CAD. Further studies are warranted to establish better the relationship between opium abuse, BLLs, and CAD.
CFD-aided contraction-expansion static mixer design for oil-in-water emulsification
Authors: Balbi María del Pilar , Fleite Santiago , Cassanello Miryan 
Published: March 2024

Abstract
Contraction-expansion (CE) static mixers can enable solid-liquid and liquid-liquid dispersion with low energy dissipation, low risk of obstruction, and without moving parts. In this work, the influence of CE elements of different geometries on the imposed turbulence of a flowing liquid has been assessed by a two-dimensional computational fluid dynamic (2D-CFD) simulation. The effect of CE on the dispersion of droplets of an immiscible liquid has also been analysed from simulations, using the volume of fluid (VOF) approach. Direct numerical simulation (DNS) performed by the open-source Gerris Flow Solver software was used to get the velocity fields and turbulence characteristics. Different ratios of CE diameters and lengths were analysed for liquid Reynolds numbers from 500 to 20,000. From simulations, the CE geometry that maximised the average root mean square velocity, as an indicator of turbulence, was determined for different liquid flow rates. It was found that the average RMS had a maximum for a wide range of liquid flow rates when the CE diameter ratio was between 0.55 and 0.59 and the length ratio was between 0.2 and 0.3. Then, a device with seven CE elements with geometrical features within this range was built and used for preparing an oil-in-water emulsion. The test system contained water and sunflower oil (5 % v/v) with the further addition of TritonX100 (0.5 % in volume of the solution) as surfactant. The stability of the emulsions was assessed by measuring the time evolution of turbidity (absorbance at 860 nm), to get the initial separation velocities. The emulsions prepared using the CE device showed initial phase separation rates lower than the one obtained in a stirred flask, evidencing the feasibility of using CE static mixers for preparing emulsions with relatively low energy consumption. Moreover, the emulsions obtained with the CE device, although dependent on the flow rate, showed similar features when obtained with 10, 100 and 250 passes through the CE static mixer.
Stability analysis of Hub dam under rapid drawdown
Authors: Salman Mohammed Mohsin , Abraheim Ahmed Kamil , Al-Attabi Ali Mohammed Ali Naji 
Published: March 2024

Abstract
The purpose of this study was to calculate the Hub dam’s slope stability analysis in a rapid drawdown scenario. Using the slide software, we compared four distinct analytic techniques – the Bishop, Janbu, ordinary way of slicing, and Morgenstern-Price approach – to determine whether or not a given slope would remain stable at the highest possible water level. According to the simulation outcomes, the portion of the dam upstream directly impacts the safety factor. The upstream safety factors, calculated using the Bishop approach, are 2.122 for steady-state seepage and 2.023 for the fast drawdown scenario. This ensures the Hub dam’s stability even under rapid drawdown conditions.
Novae erogationis ordinatio: Frontinus, Domitian, Nerva, and the Aqua Traiana
Authors: Taylor Rabun 
Published: March 2024

Abstract
Frontinus’ De aquaeductu urbis Romae is a profoundly political document written in part to assist Nerva at a perilous moment of dynastic rupture and uncertainty in the imperial court. A highly respected senator, Frontinus was a key figure both in legitimizing Nerva’s reign and in engineering Trajan’s succession. His tenure as curator aquarum was also fitted to this role. After the Praetorian uprising in summer 97 CE, his reforms of the aqueduct system took on greater urgency as he found ways to use water as a tool to sway senatorial opinions toward Nerva and, by fall of that year, toward Trajan. Yet he was adopting reforms and expansions of the system that had begun under Domitian. The large aqueduct projects Domitian had begun—including, it is argued, the early phases of the Aqua Traiana—were occupying Frontinus’ watermen when he entered office; this led him to misrepresent their efforts on Domitianic projects outside the city as petty thievery and corruption. He probably suspended the incipient Aqua Traiana but continued more advanced projects that promised a quicker political reward.
Protecting cardiomyocytes from hypoxia-reoxygenation injury, empaglifozin and liraglutide alone or in combination?
Authors: Amici Francesca , Ciarlo Christian , Abumusallam Jenine , Kravitz Madeline , Weber Angel-Rose , Meister Hanna , Li Zhao 
Published: March 2024

Abstract

Objectives
Empagliflozin, a sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor, and liraglutide, a GLP-1 receptor (GLP-1R) agonist, are commonly recognized for their cardiovascular benefits in individuals with type 2 diabetes (T2D). In prior studies, we have demonstrated that both drugs, alone or in combination, were able to protect cardiomyocytes from injury induced by diabetes. Mechanistic investigations also suggested that the cardioprotective effect may be independent of diabetes In this study, we utilized a hypoxia-reoxygenation (H/R) model to investigate the cardiovascular benefits of SGLT2 inhibitor empagliflozin and GLP-1 receptor (GLP-1R) agonist liraglutide, both alone and in combination, in the absence of T2D. Our hypothesis was that empagliflozin and liraglutide, either individually or in combination, would demonstrate cardioprotective properties against H/R-induced injury, with an additive and/or synergistic effect anticipated from combination therapy.

Methods
In this study, the cardiac muscle cell line, HL-1 cells, were treated with vehicle, empagliflozin, liraglutide, or a combination of the two drugs. The cells were then subjected to a hypoxia-reoxygenation (H/R) protocol, consisting of 1 h of hypoxia followed by 24 h of reoxygenation. The effects of the treatments on cytotoxicity, oxidative stress, endothelial nitric oxide synthase (eNOS) activity, phospho-protein kinase C (PKC) beta and phospho-eNOS (Thr495) expression were subsequently evaluated at the end of the treatments.

Results
We found that H/R increased cytotoxicity and reduces eNOS activity, empagliflozin, liraglutide or combination treatment attenuated some or all of these effects with the combination therapy showing the greatest improvement.

Conclusions
Empagliflozin, liraglutide or combination of these two have cardioprotective effect regardless of diabetes. Cardioprotective effects of SGLT2 inhibitor and GLP-1R agonist is additive and synergistic.
High-intensity combination exercise has the highest effect on increasing serum irisin and interleukin 6 levels in women with obesity
Authors: Hasanah Uswatun , Rejeki Purwo Sri , Wungu Citrawati Dyah Kencono , Pranoto Adi , Izzatunnisa Nabilah , Rahmanto Ilham , Halim Shariff 
Published: March 2024

Abstract

Objectives
Lifestyle, overnutrition, socioeconomic status, environmental conditions, and genetics are factors that cause obesity. Lifestyle modification with a nonpharmacological approach based on physical exercise is the starting point in overcoming obesity. However, physical exercise with the appropriate and effective intensity for obese subjects is still debated. Therefore, this study aims to prove the effect of intensity differences with aerobic-resistance combination exercise on increasing irisin and IL-6 levels in obese women.

Methods
A total of 32 obese women were selected as subjects and administered the interventions of low-intensity combination exercise (Q2), moderate-intensity combination exercise (Q3), and high-intensity combination exercise (Q4). ELISA was used to measure irisin and IL-6 levels in all samples. Statistical analysis used one-way ANOVA and Turkey’s-Honest Significant Difference (HSD) post hoc test.

Results
The mean Δ IL-6 levels in the control groups (Q1), Q2, Q3, and Q4 were 0.27 ± 2.54, 2.07 ± 2.55, 5.99 ± 6.25, and 7.98 ± 2.82 pg/mL with (p=0.015). The mean Δ irisin levels were 0.06 ± 0.81 ng/mL in Q1, 0.59 ± 0.67 ng/mL in Q2, 1.99 ± 1.65 ng/mL in Q3, 4.63 ± 3.57 ng/mL in Q4 with (p=0.001).

Conclusions
This study proved that all three types of combined exercise intensity increased myokine levels, such as irisin and IL-6. However, high-intensity combination exercise provided the most optimal improvement in myokine levels in obese women. Future studies are needed to design long-term exercise programs specifically for obese adolescent women using the findings from this study.
Cliques in derangement graphs for innately transitive groups
Authors: Fusari Marco , Previtali Andrea , Spiga Pablo 
Published: March 2024

Abstract
Given a permutation group 𝐺, the derangement graph of 𝐺 is the Cayley graph with connection set the derangements of 𝐺.
The group 𝐺 is said to be innately transitive if 𝐺 has a transitive minimal normal subgroup.
Clearly, every primitive group is innately transitive.
We show that, besides an infinite family of explicit exceptions, there exists a function

f
:

N
→
N

f\colon\mathbb{N}\to\mathbb{N}

such that, if 𝐺 is innately transitive of degree 𝑛 and the derangement graph of 𝐺 has no clique of size 𝑘, then

n
≤

f
⁢

(
k
)

n\leq f(k)

.
Motivation for this work arises from investigations on Erdős–Ko–Rado type theorems for permutation groups.
A generalization of the Brauer–Fowler theorem
Authors: Skresanov Saveliy V. 
Published: March 2024

Abstract
The famous Brauer–Fowler theorem states that the order of a finite simple group can be bounded in terms of the order of the centralizer of an involution.
Using the classification of finite simple groups, we generalize this theorem and prove that if a simple locally finite group has an involution which commutes with at most 𝑛 involutions, then the group is finite and its order is bounded in terms of 𝑛 only.
This answers a question of Strunkov from the Kourovka notebook.
Comparative study of single pump all optical fiber amplifiers (POAs) with ultra wide band and high gain fiber optic parametric amplifiers in highly nonlinear fibers
Authors: Gopalan Anitha , Simon Judy , Hemalatha Thoti , Mandhala Venkata Naresh , Neelamegam Nalini , Sukumar Binu , Madian Faten Kamel 
Published: March 2024

Abstract
This paper has clarified comparative study of single pump all optical fiber amplifiers with ultrawide band and high gain fiber optic parametric amplifiers in highly nonlinear fibers. Different amplifiers gain is demonstrated versus system distance for different light amplifiers in highly nonlinear fiber channel. As well as amplifier gain is clarified against system distance for different light amplifiers in DCF, DSF and NZDSF fiber channel. The mechanism of generation of single idler signal is studied based on single signal and pump signal. Moreover the mechanism of generation of single idler signal is analyzed and investigated clearly based on signal and two pump signals. Amplifier bandwidth is demonstrated against system distance for different fiber channel types in the presence of POA amplifiers based on 100 mW, 300 mW and 500 mW pumping power. The map of the signal losses is discussed and clarified versus wavelength band in the presence of all amplification techniques. Light signal per noise ratio and bit error rates are demonstrated against system distance for different fiber channel types in the presence of POA amplifiers based on 100 mW, 300 mW and 500 mW pumping power. POA is more suitable for the operation in HNLF fiber channel in compared to other proposed fiber communication channels. All optical amplifiers operation performance gain efficiency is compared together in different fiber channel media. The system can be employed with POAs for the fiber reach up to 100 km distance with a suitable amplifier gain and bandwidth. An important criteria for any amplifier is its gain and bandwidth for the compensation of the system loss and dispersion together. The optimum suitable pumping power is clarified for upgrade the system amplifier performance signature.
Thermal transport energy performance on tangent hyperbolic hybrid nanofluids and their implementation in concentrated solar aircraft wings
Authors: Obalalu Adebowale Martins , Khan Umair , Olayemi Olalekan Adebayo , Zaib Aurang , Ishak Anuar , Sherif El-Sayed M. 
Published: March 2024

Abstract
The primary heat source from the sunlight is solar energy (SE), which is used in photovoltaic (PV) panels, solar power plates, PV, streetlights, and solar-based hybrid nanocomposites. Currently, research is focused on analyzing and improving the efficiency of SE, particularly for powering aircraft, by combining solar power with nanotechnology advancements. As such, this study focuses on examining concentrated solar power and proposes a method to improve the performance of solar airplanes by employing nanotechnology. Furthermore, the work is based on the investigation of the flow rate, thermal distribution, and entropy generation of the magnetized tangent hyperbolic hybrid nanofluid (HNF) along the interior parabolic solar trough collector of an aircraft wing. This work utilizes similarity variables to simplify the partial derivative model into ordinary differential equations. These equations are then solved using the Galerkin weighted residual approach with the help of MATHEMATICA 11.3 software. From the obtained outcomes, it is reflected that the HNFs have high thermal conductivity than the NF. Intensification of Weissenberg number improves the performance of airplane wings subjected to heat transmission. Therefore, this research contributes to improved thermal management in advanced nanotechnology and solar aircraft.