bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterisation of biomarkers of intestinal barrier function in response to a high fat/high carbohydrate meal and corticotropin releasing hormone
Authors: Mogilevski Tamara , Rosella Sam , Nguyen Anke , Fitzpatrick Jessica , Parker Francis , Halmos Emma P. , Gibson Peter R. 
Published: February 2024

Background
Variation of circulating concentrations of putative biomarkers of intestinal barrier function over the day and after acute physiological interventions are poorly documented on humans. This study aimed to examine the stability and pharmacokinetics of changes in plasma concentrations of intestinal Fatty-acid -binding -protein (IFABP), Lipopolysaccharide-binging–protein (LBP), soluble CD14, and Syndecan-1 after acute stress and high fat-high-carbohydrate meal.

Methods
In a single-blinded, cross-over, randomised study, healthy volunteers received on separate days corticotropin-releasing hormone (CRH, 100 μg) or normal saline (as placebo) intravenously in random order, then a HFHC meal. Participants were allowed low caloric food. Markers of intestinal barrier function were measured at set timed intervals from 30 minutes before to 24 hours after interventions.

Results
10 participants (50% female) completed all three arms of the study. IFABP decreased by median 3.6 (IQR 1.4–10)% from -30 minutes to zero time (p = 0.001) and further reduced by 25 (20–52)% at 24 hours (p = 0.01) on the low caloric diet, but did not change in response to the meal. Syndecan-1, LBP and sCD14 were stable over a 24-hour period and not affected acutely by food intake. LBP levels 2 hours after CRH reduced by 0.61 (-0.95 to 0.05) μg/ml compared with 0.16 (-0.3 to 0.5) μg/ml post placebo injection (p = 0.05), but other markers did not change.

Conclusion
Concentrations of IFABP, but not other markers, are unstable over 24 hours and should be measured fasting. A HFHC meal does not change intestinal permeability. Transient reduction of LPB after CRH confirms acute barrier dysfunction during stress.
Femoral anterior condyle height decreases as the distal anteroposterior size increases in total knee arthroplasty: A comparative study
Authors: Yang Bo , Yuan Fu-zhen , Wang Hai-jun , Gong Xi , Chang Yan-hai , Yu Jia-Kuo 
Published: February 2024

Purpose
The anterior flange height of the current femoral component increases with an increasing distal femoral anteroposterior dimension. During total knee arthroplasty (TKA), we have observed that a large femur may have a thinner anterior condyle, whereas a small femur may have a thicker anterior condyle. The first purpose of this study was to examine whether the femoral anterior condyle height decreases as the distal femoral anteroposterior size increases and whether gender differences exist in anterior condyle height.

Methods
A total of 1218 knees undergoing TKA intraoperative and computed tomography scans from 303 healthy knees were used to measure the anterior lateral condylar height (ALCH), anterior medial condylar height (AMCH), and the lateral anteroposterior (LAP) and medial anteroposterior (MAP) dimensions of distal femurs. The LAP and MAP measurements were used for adjustments to determine whether gender differences exist in anterior condyle heights. Linear regression analysis was performed to determine correlations between ALCH and LAP or between AMCH and MAP.

Results
There were significant differences between males and females in ALCH in both the CT and TKA groups and AMCH in the CT group (all P<0.01). After adjusting for LAP and MAP, there were significant gender differences in the lateral and medial condylar heights in both groups (P<0.01). There were significant negative correlations between ALCH and LAP values and between AMCH and MAP values in both CT and TKA measurements, with the LAP and MAP values increasing as ALCH and AMCH decreased.

Conclusions
The results demonstrate that femoral anterior condylar height decreased with increasing anteroposterior dimension in both the medial and lateral condyle. In addition, this study also showed that anterior condylar heights are highly variable, with gender differences. The data may provide an important reference for designing femoral anterior flange thickness to precisely match the natural anterior condylar anatomy.
A retrospective comparison of the biceps femoris long head muscle structure in athletes with and without hamstring strain injury history
Authors: Yagiz Gokhan , Fredianto Meiky , Ulfa Maria , Ariani Indira , Agustin Avika Dwi , Shida Nami , Moore E. Whitney G. , Kubis Hans-Peter 
Published: February 2024

Introduction
Hamstring strain injuries (HSI) and re-injuries are endemic in high-speed running sports. The biceps femoris long head (BFlh) is the most frequently injured muscle among the hamstrings. Structural parameters of the hamstring muscle are stated to be susceptible to strain injuries at this location. This retrospective study targeted comparing the BFlh’s structural parameters between previously injured and uninjured athletes.

Methods
Nineteen male athletes with previous BFlh strain injury history and nineteen athletes without former lower extremity injury history were included in this study. Fascicle length, mid-muscle belly and distal musculotendinous (MTJ) passive stiffnesses of the biceps femoris long head (BFlh) were examined via b-mode panoramic ultrasound scanning and ultrasound-based shear-wave elastography. Parameter comparisons of both legs within and between athletes with and without injury history were performed.

Results
Comparison of the BFlh fascicle length between the injured leg of the injured group and the legs of the controls revealed a trend to shorter fascicle lengths in the injured leg (p = 0.067, d = -0.62). However, the mid-muscle belly passive stiffness of the BFlh was significantly higher in the injured legs (p = 0.009, d = 0.7) compared with the controls. Additionally, the distal MTJ stiffness was much higher in the previously injured legs compared with controls (p < 0.001, d = 1.6).

Conclusions
Outcomes support the importance of BFlh properties related to stiffness, and fascicle length for injury susceptibility in athletes. Future prospective studies should determine whether the higher stiffness in the injured athletes is a cause or consequence of the HSI. Physical therapy and rehabilitation programmes after HSI should focus on BFlh muscle properties i.e., elasticity and fascicle length for reducing re-injury and increasing sports performance.
Surgical safety checklist compliance process as a moral hazard: An institutional ethnography
Authors: Facey Marcia , Baxter Nancy , Hammond Mobilio Melanie , Peter Elizabeth , Moulton Carol-anne , Paradis Elise 
Published: February 2024

Background
Charting is an essential component of professional nursing practice and is arguably a key element of patient safety in surgery: without proper, objective, and timely documentation, both benign and tragical errors can occur. From surgery on wrong patients to wrong limbs, to the omission of antibiotics administration, many harms can happen in the operating room. Documentation has thus served as a safeguard for patient safety, professional responsibility, and professional accountability. In this context, we were puzzled by the practices we observed with respect to charting compliance with the surgical safety checklist (SSC) during a study of surgical teams in a large, urban teaching hospital in Canada (pseudonym ‘C&C’).

Methods
This article leverages institutional ethnography and a subset of data from a larger study to describe and explain the social organisation of the system that monitored surgical safety compliance at C&C from the standpoint of operating room nurses. This data included fieldnotes from observations of 51 surgical cases, on-the-spot interviews with nurses, formal interviews with individuals who were involved in the design and implementation of the SSC, and open-ended questions from two rounds of survey of OR teams.

Findings
We found that the compliance form and not the SSC itself formed the basis for reporting. To meet hospital accuracy in charting goals and legislated compliance documentation reporting requirements nurses ‘pre-charted’ compliance with the surgical checklist. The adoption of this workaround technically violated nursing charting principles and put them in ethically untenable positions.

Conclusions
Documenting compliance of the SSC constituted a moral hazard, constrained nurses’ autonomy and moral agency, and obscured poor checklist adherence. The findings highlight how local and extra local texts, technologies and relations create ethical issues, raise questions about the effectiveness of resulting data for decision-making and contribute to ongoing conversations about nursing workarounds.
Development of the UPSIDES global mental health training programme for peer support workers: Perspectives from stakeholders in low, middle and high-income countries
Authors: Nixdorf Rebecca , Kotera Yasuhiro , Baillie Dave , Garber Epstein Paula , Hall Cerdic , Hiltensperger Ramona , Korde Palak , Moran Galia , Mpango Richard , Nakku Juliet , Puschner Bernd , Ramesh Mary , Repper Julie , Shamba Donat , Slade Mike , Kalha Jasmine , Mahlke Candelaria 
Published: February 2024

Background
Peer support in mental health is a low-threshold intervention with increasing evidence for enhancing personal recovery and empowerment of persons living with severe mental health conditions. As peer support spreads globally, there is a growing need for peer support training programmes that work well in different contexts and cultures. This study evaluates the applicability and transferability of implementing a manualised multi-national training programme for mental health peer support workers called UPSIDES from the perspective of different local stakeholders in high-, middle-, and low-income countries.

Method
Data from seven focus groups across six study sites in Africa (Tanzania, Uganda), Asia (India, Israel), and Europe (Germany 2 sites) with 44 participants (3 service users, 7 peer support workers, 25 mental health staff members, 6 clinical directors and 3 local community stakeholders) were thematically analysed.

Results
397 codes were identified, which were thematically analysed. Five implementation enablers were identified: (i) Enhancing applicability through better guidance and clarity of training programme management, (ii) provision of sufficient time for training, (iii) addressing negative attitudes towards peer support workers by additional training of organisations and staff, (iv) inclusion of core components in the training manual such as communication skills, and (v) addressing cultural differences of society, mental health services and discrimination of mental health conditions.

Discussion
Participants in all focus groups discussed the implementation of the training and peer support intervention to a greater extent than the content of the training. This is in line with growing literature of difficulties in the implementation of peer support including difficulties in hiring peer support workers, lack of funding, and lack of role clarity. The results of this qualitative study with stakeholders from different mental health settings worldwide emphasises the need to further investigate the successful implementation of peer support training. All results have been incorporated into the manualisation of the UPSIDES peer support training.
Meta-analysis of the effectiveness and safety of robotic-assisted versus laparoscopic transabdominal preperitoneal repair for inguinal hernia
Authors: Li Xi , Li Yue-Juan , Dong Hui , Wang Deng-Chao , Wei Jian 
Published: February 2024

Background
Inguinal hernia is a common global disease. This study aims to investigate the effectiveness and safety of robot-assisted transabdominal preperitoneal repair (RTAPP) and laparoscopic transabdominal preperitoneal repair (LTAPP) for inguinal hernia.

Methods
We conducted a thorough search in Cochrane Library, Embase, and PubMed for relevant clinical studies. After applying inclusion and exclusion criteria, the quality of selected studies was assessed using the Jadad scale for randomized controlled studies and the Newcastle-Ottawa scale for observational studies. Meta-analysis was performed using RevMan 5.3 software.

Results
A total of ten studies were included, comprising two randomized controlled studies and eight non-randomized controlled studies. Meta-analysis results revealed no statistically significant differences between the RTAPP group and the LTAPP group regarding hospital stay [MD = 0.21 days, 95% CI (-0.09, 0.51), P = 0.17], incidence of seroma [OR = 0.85, 95% CI(0.45, 1.59), P = 0.61], overall complication rate [OR = 1.22, 95% CI(0.68, 2.18), P = 0.51], readmission rate [OR = 1.31, 95% CI(0.23, 7.47), P = 0.76], and recurrence rate [OR = 0.82, 95% CI(0.22, 3.07), P = 0.77]. However, the RTAPP group had longer operation time compared to the LTAPP group [MD = 14.02 minutes, 95% CI (6.65, 21.39), P = 0.0002], and the cost of the RTAPP procedure was higher than that of the LTAPP procedure [MD = $4.17 thousand, 95% CI (2.59, 5.76), P<0.00001].

Conclusion
RTAPP for inguinal hernia is a safe and feasible approach, however, it is associated with increased operation time and treatment costs.
Treatment of cognitive impairment in patients with cerebral infarction in the internal carotid arteries circulation system: results of a multicentre, randomized, double-blind, placebo-controlled clinical trial
Authors: Khasanova D. R. , Yakupova A. A. , Kamchatnov P. R. , Chefranova Zh. Yu. , Bogdanov E. I. , Pilipenko P. I , Khasanova N. M. 
Published: February 2024

Objective: to evaluate the efficacy and safety of the Prospecta drug in the treatment of cognitive impairment (CI) in patients with ischemic stroke (IS) in the carotid vascular territory.Material and methods. The double-blind, placebo-controlled, randomized clinical trial enrolled 246 patients aged 40 to 75 years with IS in the carotid vascular territory within 72 hours of stroke onset, moderate CI (<26 points on the Montreal Cognitive Assessment, MoCA), full consciousness (15 points on the Glasgow Coma Scale), moderate severity of stroke (8–12 points on the National Institute of Health Stroke Scale, NIHSS), moderate impairment of activity (2–3 points on the – Modified Rankin Scale, mRs). At visit 1, complaints and medical history were collected, vital signs (VS) and laboratory parameters were recorded, CI was assessed according to MoCA and the Glasgow Coma Scale, NIHSS and mRs were filled out. Patients were randomized into two groups: in the first group they received Prospecta for 90 days, in the second group placebo (PL) following a similar regimen. The groups were comparable in terms of demographic and baseline clinical characteristics. After 90 days, complaints, medical history, VS, laboratory parameters and assessment of CI according to MoCA were recorded, and NIHSS and mRs questionnaires were filled out again. The intention-to-treat (ITT) efficacy analysis was performed based on the results of the treatment and follow-up of the Full analysis set (FAS), which comprised 241 patients (122 patients in the Prospecta group and 119 patients in the PL group; 4 patients were excluded from the ITT analysis because they were erroneously included in the study). The results of the per-protocol (PP) analysis are shown in square brackets.Results. The 90-day use of Prospecta reduced the severity of CI in patients with carotid IS compared with placebo therapy. MoCA scale scores increased from 20.7±3.5 [20.9±3.0] to 24.6±2.9 [25.2±2.5] points in the Prospecta group and from 21.7±2.4 [21.6±2.4] to 24.5±3.0 [24.8±2.8] points in the PL group (p=0.0006 [p=0.0014]). 42 adverse events (AEs) were recorded in 32 (26.0%) patients in the Prospecta group and 37 AEs in 28 (23.0%) patients in the PL group (p=0.656). All AEs in the Prospecta group were not significantly related to the use of the drug. No deaths or recurrent IS were recorded.Conclusion. Prospecta is an effective and safe treatment for CI in patients with carotid IS
Normatywna i rekonstrukcyjna perspektywa ujmowania metodologii badań w pedagogice
Authors: Urbaniak-Zając Danuta 
Published: February 2024

The fundamental purpose of the article is to signal the premises for giving a greater importance to reconstructive methodology and to recall its possible dimensions (or generality levels of methodological research). The author begins by recalling the context of supplying the scientific method with a distinguished status, which justifies the dominance of the normative character of methodology in the researchers’ minds. She notes the importance of sociocultural factors for changes in the social sciences research practice, as well as the new understanding of practice by some contemporary philosophers, which justifies the granting of greater status to research practice. In the final part of the article, she presents levels of methodological reconstruction. Focusing on research practice will make it possible to see methodological innovations as a reaction to the change of conditions for conducting scientific research and as a search for ways to transcend the cognitive obstacles encountered.
Is Data the New Gold? Considering Intellectual Property Protection and Regulation of Data
Authors: Rockett Katharine 
Published: February 2024

Abstract
This article reviews the economics literature on the optimal design of intellectual property, the current framework for protecting data, focussing on the European Union, and the main features of data. It combines these to ask how current intellectual property protection instruments and surrounding regulation could be adapted to more usefully protect (non-personal) data that require investment to create and encourage its diffusion. The main changes from current protections include an expansion of registration and cataloguing systems, more definition of quality certification, and increased attention to portfolios of protection mechanisms.
Electron-assisted probing of polaritonic light–matter states
Authors: Abad-Arredondo Jaime , Fernández-Domínguez Antonio I. 
Published: February 2024

Abstract
Thanks to their exceptional spatial, spectral and temporal resolution, highly-coherent free-electron beams have emerged as powerful probes for material excitations, enabling their characterization even in the quantum regime. Here, we investigate strong light–matter coupling through monochromatic and modulated electron wavepackets. In particular, we consider an archetypal target, comprising a nanophotonic cavity next to a single two-level emitter. We propose a model Hamiltonian describing the coherent interaction between the passing electron beam and the hybrid photonic–excitonic target, which is constructed using macroscopic quantum electrodynamics and fully parameterized in terms of the electromagnetic dyadic Green’s function. Using this framework, we first describe electron-energy-loss and cathodoluminescence spectroscopies, and photon-induced near-field electron emission microscopy. Finally, we show the power of modulated electrons beams as quantum tools for the manipulation of polaritonic targets presenting a complex energy landscape of excitations.
BRCA mutation in Vietnamese prostate cancer patients: a mixed cross-sectional study and case series
Authors: Cam Pham Phuong , Van Pham Thai , Doan Dinh Long , Thuan Nguyen Loi , Viet Le Nam , Bich Bui Mai , Quang Nguyen Hung , Van Pham Tuyen , Thuy Thi Vo Quynh , Binh Vu Thu , Thu Thi Vu Hien , Bich Thi Le Ngoc , Quoc Hoang Binh , Lan Thi Luong Anh , Thi Nguyen Hoai , Phuong Thi Nguyen Ly , Minh Pham Lanh , Phuong Ngo Thuy , Minh Nguyen Hien , Ngoc Tran Dang , Truong Nguyen Vien , Trong Mai Khoa 
Published: February 2024

Abstract

Objectives
Prostate cancer features have been linked to mutations in the BRCA1 and BRCA2 genes. Assessing the status of BRCA1 and BRCA2 gene carriers in patients contributes to accurate diagnosis, disease prognosis as well as appropriate targeted treatment methods. This study evaluated the prevalence of these mutations in Vietnamese prostate cancer patients and assessed their correlation with clinical features.

Methods
A cross-sectional study was performed at Bach Mai Hospital between 2021 and 2022. We enrolled 60 prostate cancer patients. Next-generation gene sequencing was used to identify BRCA1 and BRCA2 mutations in formalin-fixed paraffin-embedded samples. Patients with somatic gene mutations underwent further germline mutation analysis. We also reported a case series following the British Medical Journal guidelines, detailing the clinical course of such patients.

Results
Patients with BRCA2 pathogenic variants revealed no BRCA1 mutations, although different mutations were identified. Two patients showed germline mutations. Patients with BRCA mutations were younger (average age: 66.2 years) than those with non-mutations (72.1 years) at diagnosis. High Gleason scores, lymph node metastases, and distant metastases were more prevalent in the mutation group. One patient with germline BRCA mutation had aggressive prostate cancer and early resistance to non-PARPi (Poly ADP-ribose polymerase inhibitors) treatments.

Conclusions
We provide preliminary data on BRCA mutations in Vietnamese patients with prostate cancer, suggesting that BRCA2 mutations correlate with aggressive disease characteristics. Our findings further elucidate the clinical implications of these mutations.
Hiatus resolution and linguistic diversity in Australian English
Authors: Penney Joshua , Cox Felicity , Gibson Andy 
Published: February 2024

Abstract
Vowel hiatus is typically resolved in Australian English through complementary strategies of liaison (j-gliding/w-gliding/linking-r) and glottalisation. Previous work suggests a change in progress towards increased use of glottalisation as an optimal hiatus-breaker, which creates syntagmatic contrast between adjacent vowels, particularly when the right-edge vowel is strong (i.e. at the foot boundary). Liaison continues to be used when right-edge vowels are weak, but glottalisation as a hiatus resolution strategy in general appears to be increasing and may be more common in speakers from non-English speaking backgrounds raising the question of whether exposure to linguistic diversity could be driving the change. We examine hiatus resolution in speakers from neighbourhoods that vary according to levels of language diversity. We elicited gliding and linking-r hiatus contexts to determine how prosodic strength of flanking vowels and speakers’ exposure to linguistic diversity affect hiatus resolution. Results confirm that glottalisation occurs most frequently with strong right-edge vowels, and gliding/linking-r are more likely with weak right-edge vowels. However, strategies differ between gliding and linking-r contexts, suggesting differing implementation mechanisms. In addition, speakers from ethnolinguistically diverse areas produce increased glottalisation in all contexts supporting the idea that change to the hiatus resolution system may be driven by language contact.