Genomewide Clonal Analysis of Lethal Mutations in the Drosophila melanogaster Eye: Comparison of the X Chromosome and Autosomes
Authors: Call Gerald B , Olson John M , Chen Jiong , Villarasa Nikki , Ngo Kathy T , Yabroff Allison M , Cokus Shawn , Pellegrini Matteo , Bibikova Elena , Bui Chris , Cespedes Albert , Chan Cheryl , Chan Stacy , Cheema Amrita K , Chhabra Akanksha , Chitsazzadeh Vida , Do Minh-Tu , Fang Q Angela , Folick Andrew , Goodstein Gelsey L , Huang Cheng R , Hung Tony , Kim Eunha , Kim William , Kim Yulee , Kohan Emil , Kuoy Edward , Kwak Robert , Lee Eric , Lee JiEun , Lin Henry , Liu H-C Angela , Moroz Tatiana , Prasad Tharani , Prashad Sacha L , Patananan Alexander N , Rangel Alma , Rosselli Desiree , Sidhu Sohrab , Sitz Daniel , Taber Chelsea E , Tan Jingwen , Topp Kasey , Tran PhuongThao , Tran Quynh-Minh , Unkovic Mary , Wells Maggie , Wickland Jessica , Yackle Kevin , Yavari Amir , Zaretsky Jesse M , Allen Christopher M , Alli Latifat , An Ju , Anwar Abbas , Arevalo Sonia , Ayoub Danny , Badal Shawn S , Baghdanian Armonde , Baghdanian Arthur H , Baumann Sara A , Becerra Vivian N , Chan Hei J , Chang Aileen E , Cheng Xibin A , Chin Mabel , Chong Fleurette , Crisostomo Carlyn , Datta Sanjit , Delosreyes Angela , Diep Francie , Ekanayake Preethika , Engeln Mark , Evers Elizabeth , Farshidi Farzin , Fischer Katrina , Formanes Arlene J , Gong Jun , Gupta Riju , Haas Blake E , Hahm Vicky , Hsieh Michael , Hui James Z , Iao Mei L , Jin Sophia D , Kim Angela Y , Kim Lydia S-H , King Megan , Knudsen-Robbins Chloe , Kohanchi David , Kovshilovskaya Bogdana , Ku Amy , Kung Raymond W , Landig Mark E L , Latterman Stephanie S , Lauw Stephanie S , Lee Daniel S , Lee Joann S , Lei Kai C , Leung Lesley L , Lerner Renata , Lin Jian-ya , Lin Kathleen , Lim Bryon C , Lui Crystal P Y , Liu Tiffany Q , Luong Vincent , Makshanoff Jacob , Mei An-Chi , Meza Miguel , Mikhaeil Yara A , Moarefi Majid , Nguyen Long H , Pai Shekhar S , Pandya Manish , Patel Aadit R , Picard Paul D , Safaee Michael M , Salame Carol , Sanchez Christian , Sanchez Nina , Seifert Christina C , Shah Abhishek , Shilgevorkyan Oganes H , Singh Inderroop , Soma Vanessa , Song Junia J , Srivastava Neetika , Sta.Ana Jennifer L , Sun Christie , Tan Diane , Teruya Alison S , Tikia Robyn , Tran Trinh , Travis Emily G , Trinh Jennifer D , Vo Diane , Walsh Thomas , Wong Regan S , Wu Katherine , Wu Ya-Whey , Yang Nkau X V , Yeranosian Michael , Yu James S , Zhou Jennifer J , Zhu Ran X , Abrams Anna , Abramson Amanda , Amado Latiffe , Anderson Jenny , Bashour Keenan , Beyer Elsa , Bookatz Allen , Brewer Sarah , Buu Natalie , Calvillo Stephanie , Cao Joseph , Chan Amy , Chan Jenny , Chang Aileen , Chang Daniel , Chang Yuli , Chen YiBing , Choi Joo , Chou Jeyling , Dang Peter , Datta Sumit , Davarifar Ardy , Deravanesian Artemis , Desai Poonam , Fabrikant Jordan , Farnad Shahbaz , Fu Katherine , Garcia Eddie , Garrone Nick , Gasparyan Srpouhi , Gayda Phyllis , Go Sherrylene , Goffstein Chad , Gonzalez Courtney , Guirguis Mariam , Hassid Ryan , Hermogeno Brenda , Hong Julie , Hong Aria , Hovestreydt Lindsay , Hu Charles , Huff Devon , Jamshidian Farid , Jen James , Kahen Katrin , Kao Linda , Kelley Melissa , Kho Thomas , Kim Yein , Kim Sarah , Kirkpatrick Brian , Langenbacher Adam , Laxamana Santino , Lee Janet , Lee Chris , Lee So-Youn , Lee ToHang S , Lee Toni , Lewis Gemma , Lezcano Sheila , Lin Peter , Luu Thanh , Luu Julie , Marrs Will , Marsh Erin , Marshall Jamie , Min Sarah , Minasian Tanya , Minye Helena , Misra Amit , Morimoto Miles , Moshfegh Yasaman , Murray Jessica , Nguyen Kha , Nguyen Cynthia , Nodado Ernesto , O'Donahue Amanda , Onugha Ndidi , Orjiakor Nneka , Padhiar Bhavin , Paul Eric , Pavel-Dinu Mara , Pavlenko Alex , Paz Edwin , Phaklides Sarah , Pham Lephong , Poulose Preethi , Powell Russell , Pusic Aya , Ramola Divi , Regalia Kirsten , Ribbens Meghann , Rifai Bassel , Saakyan Manyak , Saarikoski Pamela , Segura Miriam , Shadpour Farnaz , Shemmassian Aram , Singh Ramnik , Singh Vivek , Skinner Emily , Solomin Daniel , Soneji Kosha , Spivey Kristin , Stageberg Erika , Stavchanskiy Marina , Tekchandani Leena , Thai Leo , Thiyanaratnam Jayantha , Tong Maurine , Toor Aneet , Tovar Steve , Trangsrud Kelly , Tsang Wah-Yung , Uemura Marc , Vollmer Emily , Weiss Emily , Wood Damien , Wu Joy , Wu Sophia , Wu Winston , Xu Qing , Yamauchi Yuki , Yarosh Will , Yee Laura , Yen George , Banerjee Utpal 
Published: August 2007

Abstract
Using a large consortium of undergraduate students in an organized program at the University of California, Los Angeles (UCLA), we have undertaken a functional genomic screen in the Drosophila eye. In addition to the educational value of discovery-based learning, this article presents the first comprehensive genomewide analysis of essential genes involved in eye development. The data reveal the surprising result that the X chromosome has almost twice the frequency of essential genes involved in eye development as that found on the autosomes.