bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social support among chronically ill adolescent and young adult patients using a hospital-based online health community as part of a palliative care program: A qualitative study
Authors: LeBeau Kelsea , Raponi Jayne-Marie , Walker Drew , Swygert Anna , Marchi Emily 
Published: March 2024

AbstractObjectivesChronically ill adolescent and young adult (AYA) patients experience barriers to accessing psychosocial support/palliative care, increasing their risk for negative psychosocial outcomes. Online health communities (OHCs) have been recommended for AYAs as part of palliative care support programs; however, we lack research investigating palliative care programs targeting AYAs’ psychosocial support needs that are delivered virtually and able to engage with patients both during and beyond inpatient admissions. Streetlight is a palliative care program designed for chronically ill AYAs. Developed as a complementary component that extends beyond the hospital setting, Streetlight Gaming and Online Team (SGOT) is an OHC aimed at facilitating social support to influence psychosocial outcomes. We investigated the existence and enactment of social support among chronically ill AYAs using SGOT and compared this to existing online social support categories to determine which support types are present within SGOT.MethodsThis was a qualitative phenomenological study. We performed deductive thematic analysis based on existing online social support categories. Nine semi-structured interviews were conducted with SGOT participants.ResultsSocial companionship/belonging, esteem/emotional, and informational support were most prevalent within SGOT. Thirteen subthemes emerged representing how social support impacted AYAs’ psychosocial wellbeing. Notably, coping with/managing illness, sense of community and normalcy, recommendations and advice, and shared interests unrelated to illnesses were subthemes that resonated with AYAs and added value to their experiences.Significance of resultsSGOT is an impactful OHC used to meet AYAs’ social support needs. What makes SGOT especially unique is its virtual delivery, wherein AYAs can conveniently maintain beneficial relationships with other chronically ill same-aged peers. AYAs need spaces where they can feel normal and access continuous support, both within and beyond inpatient admissions. This study enhances our understanding of online AYA psychosocial support programs. Findings can be used by healthcare professionals to implement similar palliative care and psychosocial support programs.
The association of prognostic awareness with quality of life, spiritual well-being, psychological distress, and pain severity in patients with advanced cancer: Results from the APPROACH Study in Indonesia
Authors: Putranto Rudi , Shatri Hamzah , Irawan Cosphiadi , Gondhowiardjo Soehartati , Finkelstein Eric , Malhotra Chetna , Ozdemir Semra , Teo Irene , Yang Grace Meijuan 
Published: March 2024

AbstractBackground and objectivesAdvanced cancer patients’ understanding of their illness is key for making informed treatment decisions. Despite the known importance of patients’ awareness of their disease prognosis, it is debatable whether this awareness is positively, negatively, or not associated with clinical and psychological outcomes among patients with advanced cancer. This paper aims to determine the prevalence of and factors associated with prognostic awareness and its association with quality of life (QoL), spiritual well-being, pain control, and psychological distress in patients with advanced cancer in Indonesia.MethodsThis cross-sectional questionnaire-based survey was part of a multicountry study titled “Asian Patient Perspectives Regarding Oncology Awareness, Care and Health (APPROACH).” Patients were asked what they knew about their cancer and treatment. QoL and spiritual well-being were measured using the Functional Assessment of Cancer Therapy – General (FACT-G) and Functional Assessment of Chronic Illness Therapy – Spiritual Well-being (FACIT-Sp) questionnaire. Psychological distress experienced by patients was recorded via the Hospital Anxiety and Depression Scale. Pain severity was also assessed. Data from 160 patients were analyzed using descriptive statistics and multivariable regression models.ResultsOf the 160 patients who participated, 55 (34.4%) were unaware of their cancer stage. Those who were aware of their stage of cancer were younger than those who were not aware (45.7 years vs 50.4 years, p = .015). There was no significant difference in spiritual well-being and other domains of QoL between those who were aware and those who were not aware of their advanced cancer stage. There was also no significant difference in anxiety depression or pain severity, even after adjustment for demographic and clinical characteristics.Significant of resultsGiven the high prevalence of patients who wrongly thought their cancer was curable, more could be done to improve disease and prognostic understanding among patients with advanced cancer in Indonesia. Those who were aware of their advanced cancer stage did not have a poorer QoL, nor did they have more anxiety or depression than those who were unaware. This finding suggests that concerns about the negative impact of prognostic disclosure may be unfounded.
Identification of photothermo-insensitive with climate-smart early-maturing chickpea genotypes
Authors: S. Gurumurthy , B. C. Mamatha , P. S. Basu , K. Rudresh , T. Basavaraja , Bheemanahalli Raju , Pal Madan , Jha Prakash , K. R. Soren , J. M. Nidagundi , K. Sammi Reddy , J. Rane 
Published: March 2024

AbstractChickpea is a cool season, photothermal-sensitive crop, that is adversely affected by high temperatures (>35°C) and whose flowering is promoted by long-day conditions (>12 h). This prevents horizontal crop spread under a variety of agro-climatic conditions and the development of insensitive genotypes that perform well in all seasons. Therefore, a study was conducted to identify genotypes that are mature early, insensitive to photoperiod, high temperature and tolerant to drought stress. A set of 74 genotypes was evaluated under rainfed conditions in Kharif 2021 (off-season) to select eight promising early-maturing genotypes with high-yielding capacity. Then further investigations were conducted in five different seasons Late Kharif 2021, rabi 2021, summer 2022, early Kharif 2022 and Kharif 2022 to identify the genotypes with photothermo-insensitivity among the selected eight genotypes. With the exception of rabi 2021, each of these seasons were distinct from the chickpea's typical growing season. Among these eight, the stable genotypes which are performed better in all the seasons, especially in summer were considered, such as IPC 06-11, MNK-1, JG-14 and ICE 15654-A as a photothermo-insensitive, were able to flower and set pods with higher seed yield and, resulting in early maturity in a temperature range of 41.4/9.3°C with photoperiods of 13.1/10.9 h to reach in all seasons throughout the year. The heritability was more than 60%. Hence, these genotypes can be used as donor aids in the development of early maturing, drought stress tolerant and photothermo-insensitive chickpea.
Rapid Changes in Strength and Direction of Earth's Magnetic Field Over the Past 100,000 Years
Authors: Constable Catherine G. , Davies Christopher J. 
Published: March 2024

AbstractPrevious studies of rapid geomagnetic changes have highlighted the most extreme changes in direction and field strength found in paleomagnetic field models over the past 100 ky. Here we study distributions of rates of change in both time and space. Field models based on direct observations provide the most accurate values for rates of change, but their short duration precludes a complete description of field behavior. Broader representation is provided by time‐varying paleofield models, here including GGF100k, GGFSS70, LSMOD.2, CALS10k.2, HFM.OL1.A1, pfm9k.2, and SHAWQ‐iron age although variability across models and lack of temporal and spatial resolution of fine scale variations make direct comparisons difficult. For the paleofield we define rapid changes as exceeding the peak overall value of 0.4° yr−1 for directional changes and 150 nT yr−1 for intensities as established by the gufm1 model spanning 1590–1990 CE. We find that rapid directional changes are associated with low field strength and can spread across all latitudes during such episodes. Distributions of directional rates of change exhibit high skewness for models that include excursions. Rates of change in field intensity exceeding 150 nT yr−1 arise in brief intervals during the Holocene particularly associated with the strong field Levantine Iron Age Anomaly. Around the Laschamp excursion there are also rare localized occurrences of rapid intensity change. Limitations in current models make it difficult to define absolute rates for past changes, but we see that rapid changes are essential field characteristics not observed in the modern field that should nevertheless be regarded as an essential for Earth‐like dynamo simulations.
Robust Imaging of Fault Slip Rates in the Walker Lane and Western Great Basin From GPS Data Using a Multi‐Block Model Approach
Authors: Hammond William C. , Kreemer Corné , Blewitt Geoffrey 
Published: March 2024

AbstractThe Walker Lane (WL) in the western Great Basin (GB) is an active plate boundary system accommodating 10%–20% of the relative tectonic motion between the Pacific and North American plates. Its neotectonic framework is structurally complex, having hundreds of faults with various strikes, rakes, and crustal blocks with vertical axis rotation. Faults slip rates are key parameters needed to quantify seismic hazard in such tectonically active plate boundaries but modeling them in complex areas like the WL and GB is challenging. We present a new modeling strategy for estimating fault slip rates in complex zones of active crustal deformation using data from GPS networks. The technique does not rely on prior estimates of slip rates from geologic studies, and only uses data on the surface trace location, dip, and rake. The iterative framework generates large numbers of block models algorithmically from the fault database to obtain many estimates of slip rates for each fault. This reduces bias from subjective choices about how discontinuous faults connect and interact to accommodate strain. Each model iteration differs slightly in block boundary configuration, but all models honor geodetic and fault data, regularization, and are kinematically self‐consistent. The approach provides several advantages over bespoke models, including insensitivity to outlier data, realistic uncertainties, explicit mapping of off‐fault deformation, and slip rates that are more objective and independent of geologic slip rates. Comparisons to the U.S. National Seismic Hazard Model indicate that ∼80% of our geodetic slip rates agree with their geologic slip rates to within uncertainties.
The Ancient Lithospheric Parameters of Impact Basins on the Far Side of the Moon Based on the Mantle and Mare Basalt Load Model
Authors: Zhang Wensong , Deng Qingyun , Ye Mao , Hao Weifeng , Chen Yihao , Zheng Yingjun , Zhong Zhen , Yan Jianguo , Sun Xuemei , Li Fei 
Published: March 2024

AbstractResearch on the lithospheric elastic thickness (Te) of lunar mascon basins can provide a deeper understanding of heterogeneous thermal activity. In this study, we focused on four basins (Moscoviense, Freundlich‐Sharonov, Hertzsprung, and Apollo) located on the far side of the Moon. These basins exhibit a significant variation in admittance and correlation spectra, making it challenging to develop precise fitted models. Based on the global lunar crustal thickness model and mare basalt thickness, we developed a mantle and mare basalt load model to estimate the Te. This small Te (10.1 km) suggests a double impact process or extreme thermal activity caused by volcanism during the formation of the Moscoviense. For the typical highland basins, that is, Freundlich‐Sharonov and Hertzsprung, the Te (∼20 km) corresponds to a minimum heat flux of 34 mW m−2. Considering the additional energy introduced by the impact, this heat flux can be considered as the upper limit for the heat flux of the highland itself during the formation of a mascon basin. For the Apollo basin within the South Pole‐Aitken (SPA) terrane, the Te is 30.7 km. The crust beneath the SPA region is thinned, allowing a greater contribution of stiffer mantle material to the lithosphere, perhaps explaining the higher effective Te. Furthermore, the disparity between the highland and SPA terranes can give rise to their distinct basin formation processes. Impact basins formed within the SPA terrane may have experienced a faster cooling process compared to those formed on the highland terrane following the impact event, leading to a higher Te.
Call to Action: Screening and Addressing Caregiver Mental Health Needs Within All Pediatric Medical Subspecialty Settings as Standard of Care
Authors: Salley Christina G. , Bakula Dana M. , Driscoll Colleen F. Bechtel , Flanagan-Priore Catherine , Kapke Theresa L. , Moore Rachel M. , Parris Kendra R. , Sharkey Christina M. 
Published: March 2024

Objective: The objective of this topical review is to provide a rationale for the development of standards of care to address the mental health needs of caregivers of youth with chronic and acute conditions. Method: In this topical review, we describe the relationship between pediatric medical conditions and caregiver mental health, the state of available screening and intervention options, standards of care in medicine, existing caregiver mental health standards in pediatric subspecialty populations, and exemplar caregiver mental health programs that were developed in response to standards. Finally, we will describe our rationale for this standard of care, provide a call to action, and describe anticipated challenges in developing and implementing such standards. The content of this topical review was guided by expert knowledge, literature review, and communication with members of the American Psychological Association Division 54 through listserv communication. This review did not involve human subjects research and thus did not require Institutional Review Board approval, informed consent, or assent. Results: Standards of Care to address caregiver mental health in pediatrics is one approach to reduce gaps between caregivers’ needs and access to treatment. Standards that address caregiver mental health exist for a subset of pediatric medical subspecialty populations but are nonexistent across most pediatric populations. Conclusions: Multidisciplinary collaboration, with broad stakeholder input, could result in the writing of Standards of Care to lead to program development that addresses mental health for caregivers of children with a range of chronic and acute conditions. Implications for Impact Statement This topical review calls attention to the gap between what is known about the mental healthcare needs of caregivers of children with chronic and acute conditions and the implementation of assessments and interventions to address these needs. The development of standards of care is one way to bridge this gap and could lead to the development of universally implemented caregiver mental health supports in pediatric healthcare settings.
Changes in food preferences and ingestive behaviors after glucagon-like peptide-1 analog treatment: techniques and opportunities
Authors: Bettadapura Sahana , Dowling Katherine , Jablon Kelli , Al-Humadi Ahmed W. , le Roux Carel W. 
Published: March 2024

Abstract
Background
Glucagon-like peptide-1 (GLP-1) analogs are approved for the treatment of obesity in adults and adolescents. Reports have emerged that the weight loss effect of these medications may be related to changes in food preferences and ingestive behaviors following the treatment. Understanding the mechanisms which impact ingestive behavior could expand opportunities to develop more refined and personalized treatment options for obesity.

Methods
Recent studies investigating the relationship between GLP-1 analogs and ingestive behaviors were retrieved from PubMed using the search terms: “obesity,” “food preference,” “taste,” “ingestive behavior,” “weight loss medication,” “anti-obesity medication,” “GLP-1 analog,” “tirzepatide,” “liraglutide,” “semaglutide.” Measurement tools were studied to compare variables used to assess food intake behavior. The main outcomes from each study were analyzed to evaluate the current standing and future directions of appetitive, ingestive, and consummatory behaviors and their association with GLP-1 analogs.

Results
Thus far, studies have primarily explored the weight loss phase and report decreased short-term appetite and food intake upon treatment. However, research during the weight maintenance phase and objective measurements of food intake are notably sparse. Additionally, verbal reports have been primarily used to examine food intake, which can be susceptible to subjectivity.

Conclusions
Elucidating the relationship between GLP-1 analogs and ingestive behavior could reveal additional parameters which contribute to their anti-obesity effects. To better understand these mechanisms, it is imperative to consider objective measurements of food intake in future studies. Several measurement tools have been adapted to measure variables of food behavior in humans, and each must be carefully considered with their strengths and limitations to develop optimal investigations.
Comparative effectiveness research trial for antidepressant incomplete and non-responders with treatment resistant depression (ASCERTAIN-TRD) a randomized clinical trial
Authors: Papakostas George I. , Trivedi Madhukar H. , Shelton Richard C. , Iosifescu Dan V. , Thase Michael E. , Jha Manish K. , Mathew Sanjay J. , DeBattista Charles , Dokucu Mehmet E. , Brawman-Mintzer Olga , Currier Glenn W. , McCall William Vaughn , Modirrousta Mandana , Macaluso Matthew , Bystritsky Alexander , Rodriguez Fidel Vila , Nelson Erik B. , Yeung Albert S. , Feeney Anna , MacGregor Leslie C. , Carmody Thomas , Fava Maurizio 
Published: March 2024

AbstractFurther research is needed to help improve both the standard of care and the outcome for patients with treatment-resistant depression. A particularly critical evidence gap exists with respect to whether pharmacological or non-pharmacological augmentation is superior to antidepressant switch, or vice-versa. The objective of this study was to compare the effectiveness of augmentation with aripiprazole or repetitive transcranial magnetic stimulation versus switching to the antidepressant venlafaxine XR (or duloxetine for those not eligible to receive venlafaxine) for treatment-resistant depression. In this multi-site, 8-week, randomized, open-label study, 278 subjects (196 females and 82 males, mean age 45.6 years (SD 15.3)) with treatment-resistant depression were assigned in a 1:1:1 fashion to treatment with either of these three interventions; 235 subjects completed the study. 260 randomized subjects with at least one post-baseline Montgomery-Asberg Depression Rating (MADRS) assessment were included in the analysis. Repetitive transcranial magnetic stimulation (score change (standard error (se)) = −17.39 (1.3) (p = 0.015) but not aripiprazole augmentation (score change (se) = −14.9 (1.1) (p = 0.069) was superior to switch (score change (se) = −13.22 (1.1)) on the MADRS. Aripiprazole (mean change (se) = −37.79 (2.9) (p = 0.003) but not repetitive transcranial magnetic stimulation augmentation (mean change (se) = −42.96 (3.6) (p = 0.031) was superior to switch (mean change (se) = −34.45 (3.0)) on the symptoms of depression questionnaire. Repetitive transcranial magnetic stimulation augmentation was shown to be more effective than switching antidepressants in treatment-resistant depression on the study primary measure. In light of these findings, clinicians should consider repetitive transcranial magnetic stimulation augmentation early-on for treatment-resistant depression.Trial registration: ClinicalTrials.gov, NCT02977299
Proteomic analysis of the developing mammalian brain links PCDH19 to the Wnt/β-catenin signalling pathway
Authors: de Nys Rebekah , Gardner Alison , van Eyk Clare , Mincheva-Tasheva Stefka , Thomas Paul , Bhattacharjee Rudrarup , Jolly Lachlan , Martinez-Garay Isabel , Fox Ian W. J. , Kamath Karthik Shantharam , Kumar Raman , Gecz Jozef 
Published: March 2024

AbstractClustering Epilepsy (CE) is a neurological disorder caused by pathogenic variants of the Protocadherin 19 (PCDH19) gene. PCDH19 encodes a protein involved in cell adhesion and Estrogen Receptor α mediated-gene regulation. To gain further insights into the molecular role of PCDH19 in the brain, we investigated the PCDH19 interactome in the developing mouse hippocampus and cortex. Combined with a meta-analysis of all reported PCDH19 interacting proteins, our results show that PCDH19 interacts with proteins involved in actin, microtubule, and gene regulation. We report CAPZA1, αN-catenin and, importantly, β-catenin as novel PCDH19 interacting proteins. Furthermore, we show that PCDH19 is a regulator of β-catenin transcriptional activity, and that this pathway is disrupted in CE individuals. Overall, our results support the involvement of PCDH19 in the cytoskeletal network and point to signalling pathways where PCDH19 plays critical roles.
PAK3 activation promotes the tangential to radial migration switch of cortical interneurons by increasing leading process dynamics and disrupting cell polarity
Authors: Viou Lucie , Atkins Melody , Rousseau Véronique , Launay Pierre , Masson Justine , Pace Clarisse , Murakami Fujio , Barnier Jean-Vianney , Métin Christine 
Published: March 2024

AbstractMutations of PAK3, a p21-activated kinase, are associated in humans with cognitive deficits suggestive of defective cortical circuits and with frequent brain structural abnormalities. Most human variants no longer exhibit kinase activity. Since GABAergic interneurons express PAK3 as they migrate within the cortex, we here examined the role of PAK3 kinase activity in the regulation of cortical interneuron migration. During the embryonic development, cortical interneurons migrate a long distance tangentially and then re-orient radially to settle in the cortical plate, where they contribute to cortical circuits. We showed that interneurons expressing a constitutively kinase active PAK3 variant (PAK3-ca) extended shorter leading processes and exhibited unstable polarity. In the upper cortical layers, they entered the cortical plate and extended radially oriented processes. In the deep cortical layers, they exhibited erratic non-processive migration movements and accumulated in the deep pathway. Pharmacological inhibition of PAK3 kinase inhibited the radial migration switch of interneurons to the cortical plate and reduced their accumulation in the deep cortical layers. Interneurons expressing a kinase dead PAK3 variant (PAK3-kd) developed branched leading processes, maintained the same polarity during migration and exhibited processive and tangentially oriented movements in the cortex. These results reveal that PAK3 kinase activity, by promoting leading process shortening and cell polarity changes, inhibits the tangential processive migration of interneurons and favors their radial re- orientation and targeting to the cortical plate. They suggest that patients expressing PAK3 variants with impaired kinase activity likely present alterations in the cortical targeting of their GABAergic interneurons.