bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical features and molecular landscape of cuproptosis signature‐related molecular subtype in gastric cancer
Authors: Chong Wei , Ren Huicheng , Chen Hao , Xu Kang , Zhu Xingyu , Liu Yuan , Sang Yaodong , Li Han , Liu Jin , Ye Chunshui , Shang Liang , Jing Changqing , Li Leping 
Published: April 2024

AbstractRecent studies have highlighted the biological significance of cuproptosis in disease occurrence and development. However, it remains unclear whether cuproptosis signaling also has potential impacts on tumor initiation and prognosis of gastric cancer (GC). In this study, 16 cuproptosis‐related genes (CRGs) transcriptional profiles were harnessed to perform the regularized latent variable model‐based clustering in GC. A cuproptosis signature risk scoring (CSRS) scheme, based on a weighted sum of principle components of the CRGs, was used to evaluate the prognosis and risk of individual tumors of GC. Four distinct cuproptosis signature‐based clusters, characterized by differential expression patterns of CRGs, were identified among 1136 GC samples across three independent databases. The four clusters were also associated with different clinical outcomes and tumor immune contexture. Based on the CSRS, GC patients can be divided into CSRS‐High and CSRS‐Low subtypes. We found that DBT, MTF1, and ATP7A were significantly elevated in the CSRS‐High subtype, while SLC31A1, GCSH, LIAS, DLAT, FDX1, DLD, and PDHA1 were increased in the CSRS‐Low subtype. Patients with CSRS‐Low score were characterized by prolonged survival time. Further analysis indicated that CSRS‐Low score also correlated with greater tumor mutation burden (TMB) and higher mutation rates of significantly mutated genes (SMG) in GC. In addition, the CSRS‐High subtype harbored more significantly amplified focal regions related to tumorigenesis (3q27.1, 12p12.1, 11q13.3, etc.) than the CSRS‐Low tumors. Drug sensitivity analyses revealed the potential compounds for the treatment of gastric cancer with CSRS‐High score, which were experimentally validated using GC cells. This study highlights that cuproptosis signature‐based subtyping is significantly associated with different clinical features and molecular landscape of GC. Quantitative evaluation of the CSRS of individual tumors will strengthen our understanding of the occurrence and development of cuproptosis and the treatment progress of GC.
Internet financial reporting disclosure index of e‐commerce businesses on social media
Authors: Probowulan Diyah , Ardianto Ardianto 
Published: April 2024

SummaryThe study measured the Internet Financial Reporting (IFR) disclosure index and compared the results across three continents of the global e‐commerce business. In addition, it documents various social media platforms used by e‐commerce. We use content analysis with a scoring matrix based on content, timeliness, technology, and support used in websites and a one‐way ANOVA. The findings identified an average IFR e‐commerce disclosure index of 0.735, which is of good quality as it approaches the value of 1. There is no difference in index IFR between the three continental zones overall, but slightly different from non‐e‐commerce companies. The results also prove that websites and blog media still dominate the use of social media, while other social media platforms have not provided financial information. Researchers in accounting have not conducted research topics on social media, so there are still limited references and narrow analytical content. This research will interest the e‐commerce business industry and compile their financial reporting through the website to improve the quality of their IFR and financial access. Since the e‐commerce business is an internet‐based company growing significantly, it can use other social media to reveal its reporting as decent work and economic growth. This subject is relatively innovative because none of the IFR disclosure index studies focuses on e‐commerce businesses on social media. It fills the research gap related to the characteristics of e‐commerce businesses, where almost all activities are internet‐based.
Adipose tissue plasticity mediated by the counterregulatory axis of the renin‐angiotensin system: Role of Mas and MrgD receptors
Authors: Proença Ana Beatriz , Medeiros Gabriela Rodrigues , Reis Guilherme dos Santos , Losito Luiza da França , Ferraz Luiza Mazzali , Bargut Thereza Cristina Lonzetti , Soares Nícia Pedreira , Alexandre‐Santos Beatriz , Campagnole‐Santos Maria Jose , Magliano D'Angelo Carlo , Nobrega Antonio Claudio Lucas da , Santos Robson Augusto Souza , Frantz Eliete Dalla Corte 
Published: April 2024

AbstractThe renin‐angiotensin system (RAS) is an endocrine system composed of two main axes: the classical and the counterregulatory, very often displaying opposing effects. The classical axis, primarily mediated by angiotensin receptors type 1 (AT1R), is linked to obesity‐associated metabolic effects. On the other hand, the counterregulatory axis appears to exert antiobesity effects through the activation of two receptors, the G protein‐coupled receptor (MasR) and Mas‐related receptor type D (MrgD). The local RAS in adipose organ has prompted extensive research into white adipose tissue and brown adipose tissue (BAT), with a key role in regulating the cellular and metabolic plasticity of these tissues. The MasR activation favors the brown plasticity signature in the adipose organ by improve the thermogenesis, adipogenesis, and lipolysis, decrease the inflammatory state, and overall energy homeostasis. The MrgD metabolic effects are related to the maintenance of BAT functionality, but the signaling remains unexplored. This review provides a summary of RAS counterregulatory actions triggered by Mas and MrgD receptors on adipose tissue plasticity. Focus on the effects related to the morphology and function of adipose tissue, especially from animal studies, will be given targeting new avenues for treatment of obesity‐associated metabolic effects.
The relationship between the systemic immune inflammatory index and computerized tomography guided coronary lesion severity in diabetic patients
Authors: Aksu Uğur , Korucu Cem , Ekşi Ramazan Anıl , Gökaslan Çiğdem Özer 
Published: April 2024

AbstractPurposeThe incidence of cardiovascular events is high in diabetic patients. In diabetic patients, the levels of inflammatory parameters in the circulation are increased, which is associated with poor outcome. In this study, we investigated the relationship between the systemic immune inflammatory index (SII), which is a sensitive indicator of the inflammatory response, and the severity of coronary atherosclerosis in diabetic patients.Materials and MethodsDiabetic patients who underwent coronary computed tomography for chest pain were included in the study. The patients were divided into two groups according to their median systemic immune inflammatory index values, and the predictors of SII elevation were investigated.ResultsA total 210 patients were included in the study. The mean age of the patients was 52.6 ± 9.3 and 44.3% were male. In univariate analysis, HDL, triglyceride, lesion severity, and CAR were associated with high SII. In the regression analysis, lesion severity and lower HDL levels were determined as predictor of high SII.ConclusionInflammation plays an important role in the development of coronary atherosclerosis. Diabetic patients with elevated SII levels may require further investigation for significant atherosclerosis.
Discovery of low‐molecular‐weight phenylalanine derivatives as novel HIV capsid modulators with improved antiretroviral activity and metabolic stability
Authors: Jiang Xiangyi , Gao Zhen , Sharma Prem Prakash , Kumar Sumit , Rathi Brijesh , Ji Xiangkai , Dai Jiaojiao , Xie Minghui , Dong Guanyu , Xu Shujing , De Clercq Erik , Pannecouque Christophe , Dick Alexej , Zhan Peng , Liu Xinyong 
Published: April 2024

AbstractThe HIV capsid (CA) protein is a promising target for anti‐AIDS treatment due to its critical involvement in viral replication. Herein, we utilized the well‐documented CA inhibitor PF74 as our lead compound and designed a series of low‐molecular‐weight phenylalanine derivatives. Among them, compound 7t exhibited remarkable antiviral activity with a high selection index (EC50 = 0.040 µM, SI = 2815), surpassing that of PF74 (EC50 = 0.50 µM, SI = 258). Furthermore, when evaluated against the HIV‐2 strain, 7t (EC50 = 0.13 µM) demonstrated approximately 14‐fold higher potency than that of PF74 (EC50 = 1.76 µM). Insights obtained from surface plasmon resonance (SPR) revealed that 7t exhibited stronger target affinity to the CA hexamer and monomer in comparison to PF74. The potential interactions between 7t and the HIV‐1 CA were further elucidated using molecular docking and molecular dynamics simulations, providing a plausible explanation for the enhanced target affinity with 7t over PF74. Moreover, the metabolic stability assay demonstrated that 7t (T1/2 = 77.0 min) significantly outperforms PF74 (T1/2 = 0.7 min) in human liver microsome, exhibiting an improvement factor of 110‐fold. In conclusion, 7t emerges as a promising drug candidate warranting further investigation.
Rare cutaneous manifestation of B‐cell chronic lymphocytic leukaemia involving the toes
Authors: Costa Blasco Marta , Molloy Kevin , Doyle Claire , O'Brien Odharnaith , Quinn John , Ní Raghallaigh Siona 
Published: April 2024

AbstractB cell chronic lymphocytic leukaemia (B‐CLL) presenting with cutaneous infiltration is rare, and when it occurs, it presents most commonly on the head and neck. We present the case of an 80‐year‐old woman with a 2‐month history of erythema, swelling and pain affecting all her toes. She had a history of B‐CLL diagnosed 20 years previously that had remained stable under observation without treatment. A toe skin biopsy showed a diffuse infiltrate of lymphoid cells occupying the dermis composed of small mature lymphoid cells with a monotonous appearance. On immunohistochemistry, the neoplastic lymphoid cells stained positive for the B‐cell marker CD20. Overall, the morphology and immunophenotype were consistent with cutaneous involvement by chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL). We concluded that her symptoms were directly caused by skin infiltration of B‐CLL.
Modeling pulsed dye laser treatment of psoriatic plaques by combining numerical methods and image‐derived lesion morphologies
Authors: Wilk Leah S. , Doppegieter Meagan , van der Beek Nick , van Leeuwen Ton G. , Aalders Maurice C. G. 
Published: April 2024

AbstractObjectivesKnowledge of the physical effects of pulsed dye laser (PDL) treatment of psoriatic lesions is essential in unraveling the remedial mechanisms of this treatment and hence also in maximizing in its disease‐modifying potential. Therefore, the main objective of this study was to provide estimates of these physical effects (for laser wavelengths of 585 and 595 nm), with the aim of identifying pathogenic processes that may be affected by these conditions.MethodsWe modeled the laser light propagation and subsequent photothermal heating by numerically solving the transient diffusion and heat equations simultaneously. To this end, we used the finite element method in conjunction with an image‐derived psoriatic lesion morphology (which was defined by segmenting blood vessels from a confocal microscopy image of a fluorescently labeled section of a 3 mm punch biopsy of a psoriatic lesion). The resulting predictions of the generated temperature field within the lesion were then used to assess the possibility of stalling or arresting some suspected pathogenic processes.ResultsAccording to our results, it is conceivable that perivascular nerves are thermally denatured, as almost all locations that reach 60°C were found to be within 18 µm (at 585 nm) and 11 µm (at 595 nm) of a blood vessel wall. Furthermore, activation of TRPV1 and TRPV2 channels in perivascular neuronal and immune cells is highly likely, since a critical temperature of 43°C is generated at locations within up to 350 µm of a vessel wall (at both wavelengths) and sustained for up to 700 ms (at 585 nm) and 40 ms (at 595 nm), while a critical temperature of 52°C is reached by locations within 80 µm (at 585 nm) and 30 µm (at 595 nm) of a vessel wall and sustained for up to 100  ms (at 585 nm) and 30 ms (at 595 nm). Finally, we found that the blood vessel coagulation‐inducing temperature of 70°C is sustained in the vascular epithelium for up to 19 and 5 ms at 585 and 595 nm, respectively, rendering partial or total loss of vascular functionality a distinct possibility.ConclusionsThe presented approach constitutes a useful tool to provide realistic estimates of the photothermal effects of PDL treatment of psoriatic plaques (as well as other selective photothermolysis‐based treatments), yielding information that is essential in guiding future experimental studies toward unraveling the remedial mechanisms of these treatments.
Protein glycosylation in lung cancer from a mass spectrometry perspective
Authors: Balbisi Mirjam , Sugár Simon , Turiák Lilla 
Published: April 2024

AbstractLung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer. Differences in glycosylation patterns have been previously observed between healthy and cancerous samples as well as between different lung cancer subtypes, which suggests untapped diagnostic potential. In addition, understanding the changes mediated by glycosylation may shed light on possible novel therapeutic targets and personalized treatment strategies for lung cancer patients. Mass spectrometry based glycomics and glycoproteomics have emerged as powerful tools for in‐depth characterization of changes in protein glycosylation, providing valuable insights into the molecular basis of lung cancer. This paper reviews the literature on the analysis of protein glycosylation in lung cancer using mass spectrometry, which is dominated by manuscripts published over the past 5 years. Studies analyzing N‐glycosylation, O‐glycosylation, and glycosaminoglycan patterns in tissue, serum, plasma, and rare biological samples of lung cancer patients are highlighted. The current knowledge on the potential utility of glycan and glycoprotein biomarkers is also discussed.
De novo FRMD5 Missense Variants in Patients with Childhood‐Onset Ataxia, Prominent Nystagmus, and Seizures
Authors: Keller Sarmiento Ignacio J. , Bustos Bernabe I. , Blackburn Joanna , Hac Nicholas E.F. , Ruzhnikov Maura , Monroe Matthea , Levy Rebecca J. , Kinsley Lisa , Li Megan , Silani Vincenzo , Lubbe Steven J. , Krainc Dimitri , Mencacci Niccolò E. 
Published: April 2024

AbstractBackground
FRMD5 variants were recently identified in patients with developmental delay, ataxia, and eye movement abnormalities.ObjectivesWe describe 2 patients presenting with childhood‐onset ataxia, nystagmus, and seizures carrying pathogenic de novo FRMD5 variants. Weighted gene co‐expression network analysis (WGCNA) was performed to gain insights into the function of FRMD5 in the brain.MethodsTrio‐based whole‐exome sequencing was performed in both patients, and CoExp web tool was used to conduct WGCNA.ResultsBoth patients presented with developmental delay, childhood‐onset ataxia, nystagmus, and seizures. Previously unreported findings were diffuse choreoathetosis and dystonia of the hands (patient 1) and areas of abnormal magnetic resonance imaging signal in the white matter (patient 2). WGCNA showed that FRMD5 belongs to gene networks involved in neurodevelopment and oligodendrocyte function.ConclusionsWe expanded the phenotype of FRMD5‐related disease and shed light on its role in brain function and development. We recommend including FRMD5 in the genetic workup of childhood‐onset ataxia and nystagmus. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Simultaneous brain and neck time‐of‐flight MRA using spiral multiband with localized quadratic encoding
Authors: Peng Xi , Wang Dinghui , Borup Daniel , Krishnamoorthy Guruprasad , Pipe James G. 
Published: April 2024

AbstractPurposeTo develop a method that achieves simultaneous brain and neck time‐of‐flight (ToF) magnetic resonance angiography (MRA) within feasible scan timeframes.MethodsLocalized quadratic (LQ) encoding is efficient for both signal‐to‐noise ratio (SNR) and in‐flow enhancement. We proposed a spiral multiband LQ method to enable simultaneous intracranial and carotid ToF‐MRA within a single scan. To address the venous signal contamination that becomes a challenge with multiband (MB) ToF, tilt‐optimized non‐saturated excitation (TONE) and partial‐Fourier slice selection (PFSS) were further introduced in the LQ framework to mitigate the venous signal and improve artery contrast. A sequential spiral MB and LQ reconstruction pipeline was employed to obtain the brain‐and‐neck image volumes.ResultsThe proposed MB method was able to achieve simultaneous brain and neck ToF‐MRA within a 2:50‐min scan. The complementarily boosted SNR‐efficiency by MB and LQ acquisitions allows for the increased spatial coverage without increase in scan time or noticeable compromise in SNR. The incorporation of both TONE and PFSS effectively alleviated the venous contamination with improved small vessel sensitivity. Selection of scan parameters such as the LQ factor and flip angle reflected the trade‐off among SNR, blood contrast, and venous suppression.ConclusionsA novel MB spiral LQ approach was proposed to enable fast intracranial and carotid ToF‐MRA with minimized venous corruption. The method has shown promise in MRA applications where large spatial coverage is necessary.
Adipocyte‐derived inflammatory molecules induce senescent B cells through metabolic pathways
Authors: Frasca Daniela , Romero Maria , Garcia Denisse , Thaller Seth , Bueno Valquiria 
Published: April 2024

AbstractObjectiveThe aim of this study was to demonstrate that an adipocyte tissue‐derived conditioned medium (ACM) contains inflammatory molecules that induce senescence in B cells.MethodsWe incubated blood‐derived B cells from lean donors with ACM obtained from the adipose tissue of adult female donors with obesity undergoing weight reduction surgery or with medium as control. After 24 h, cells were harvested, and the expression of transcripts for proinflammatory cytokines (TNF/IL‐6), chemokines (IL‐8), and for markers of the senescence‐associated secretory phenotype (SASP) was measured by quantitative polymerase chain reaction. B cells were also stained with the marker of immunosenescence β‐galactosidase, and their metabolic status was evaluated in Seahorse using a Mito Stress Test.ResultsWe show that the incubation of B cells from lean donors with ACM induces the expression of transcripts for inflammatory and SASP transcripts, increases the amount of β‐galactosidase staining, and induces a metabolic phenotype characterized by higher basal and maximal oxygen consumption, spare respiratory capacity (difference between maximal and basal respiration), nonmitochondrial oxygen consumption, ATP production, and proton leak.ConclusionsThese results demonstrate that B cells from lean individuals, after incubation with ACM, become inflammatory and senescent, and this occurs through metabolic pathways needed to support their secretory phenotype.
Improving processability and mechanical properties of epoxy resins with biobased flame retardants
Authors: Gong Yuning , Zhang Lanyue , He Jiahuan , Liu Baiyu , Wang Lu , Ao Yuhui , Liu Yu , Shang Lei 
Published: April 2024

AbstractIntegrating flame‐retardant additives into epoxy resins is an essential strategy for improving their fire resistance. However, introducing flame‐retardant groups often compromises the processability and mechanical integrity of such resins. In this research, we synthesized a novel, biobased flame retardant, referred to as DPN, using naringenin and chlorodiphenylphosphine as precursors via a straightforward single‐step process. The addition of DPN markedly decreased the viscosity of hydantoin epoxy resin, from 7468 to 1285 mPa s. Furthermore, when cured with 4,4‐diaminodiphenylmethane, the composite containing five equivalents of DPN (DPN‐5) exhibited a marked improvement in mechanical strength, reaching 190 MPa, significantly outperforming the pure thermoset (DPN‐0: 104 MPa), while preserving high transparency. Combustion tests further confirmed that DPN significantly boosts the flame resistance of the thermoset, with DPN‐5 achieving a limiting oxygen index of 37% and securing a UL‐94 V‐0 rating. Cone calorimetry analysis showed that DPN‐5 effectively reduced heat and smoke production during combustion, achieving a 13.4% reduction in peak heat release rate and a 28.2% decrease in total heat release compared to DPN‐0. This study underscores the potential of multifunctional biobased flame retardants derived from renewable resources in advancing the development of high‐performance materials. © 2024 Society of Industrial Chemistry.
Registration of ‘CP 10‐1620’ sugarcane
Authors: Davidson R. Wayne , Gordon Vanessa S. , Islam Md. , McCord Per , Sandhu Hardev S. , Zhao Duli , Sood Sushma , Comstock Jack C. , Singh Maninder P. , Baltazar Miguel 
Published: April 2024

Abstract‘CP 10‐1620’ (Reg. no. CV‐216, PI 693837) sugarcane (a complex hybrid of Saccharum spp.) was developed through cooperative research conducted by the USDA–ARS, the University of Florida, and the Florida Sugar Cane League, Inc. At the June 7, 2018, Florida Sugarcane Variety Committee Meeting, CP 10‐1620 was released to growers for mineral (sand) soils in Florida, and seed was available in September 2018. CP 10‐1620 was selected from a polycross of ‘CP 00‐1100’ × ‘CP 05‐1740’ (Cross no. X07‐1225) made at Canal Point, FL, in December 2007. Neither the female parent, CP 00‐1100, nor the male parent, CP 05‐1740, is a commercial cultivar. Cane yield of CP 10‐1620 on sand soils, averaged across 12 harvests through three crop cycles (plant cane, first ratoon, and second ratoon), was 11.0% higher (P < 0.05) than the combined mean of three checks, ‘CL 88‐4730’, ‘CP 96‐1252’, and ‘CPCL 97‐2730’, which are commercial checks for sand soils. The commercial recoverable sucrose for CP 10‐1620 was not significantly lower than the combined mean of the checks but the higher cane yield resulted in 8.4% higher (P < 0.05) sucrose yield than the combined mean of the checks. CP 10‐1620 was released because of its high cane yields on sand soils, and its acceptable levels of resistance to brown rust (caused by Puccinia melanocephala H. & P. Sydow), leaf scald (caused by Xanthomonas albilineans Ashby, Dowson), Sugarcane mosaic virus strain E (mosaic), smut (caused by Sporisorium scitamineum), Sugarcane yellow leaf virus, and ratoon stunt [caused by Leifsonia xyli subsp. xyli (Davis et al.) Evtushenko]. CP 10‐1620 was moderately susceptible to orange rust (caused by Puccinia kuehnii E. J. Butler), and it has high freeze tolerance. CP 10‐1620 tested positive for the Bru1 locus, which is an indicator of brown rust resistance.