bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Close Look at Short CCH3⋅⋅⋅Potassium Contacts: Synthetic and Theoretical Investigations of [M2Co2(μ3‐OtBu)2(μ2‐OtBu)4(thf)n] (M=Na, K, Rb, thf=tetrahydrofuran)
Authors: Anson Christopher E. , Klopper Wim , Li Jin‐Shan , Ponikiewski Lukasz , Rothenberger Alexander 
Published: December 2005

AbstractAgostic interactions of the type SiCH3⋅⋅⋅M+ (M=alkali metal) are frequently mentioned in discussions of solid‐state structures of trimethylsilyl compounds and the purpose of this work was to elucidate if they also exist in the related tert‐butyl species by using density functional theory. The compounds [M2Co2(μ3‐OtBu)2(μ2‐OtBu)4(thf)n] (M=Na, n=2; M=K, n=0; M=Rb, n=1) have been synthesised and their crystal structures determined. Close contacts of methyl groups with K atoms are observed in the solid‐state structure of [K2Co2(μ3‐OtBu)2(μ2‐OtBu)4], and calculations of the rotational barrier of a tert‐butoxy group about the axis through the CO bond were performed. It was shown that apparent short CCH3⋅⋅⋅K distances are in this case a consequence of the packing in the extended solid‐state structure.
Pyrazole Complexes as Anion Receptors
Authors: Nieto Sonia , Pérez Julio , Riera Lucía , Riera Víctor , Miguel Daniel 
Published: December 2005

AbstractThe behavior of the receptors [Re(CO)3(Hdmpz)3]BAr′4 (Hdmpz=3,5‐dimethylpyrazole) (1) and [Re(CO)3(HtBupz)3]BAr′4 (HtBupz=3(5)‐tert‐butylpyrazole) (2; Ar′=3,5‐bis(trifluoromethyl)phenyl) toward the anions fluoride, chloride, bromide, iodide, hydrogensulfate, dihydrogenphosphate, nitrate, and perrhenate was studied in CD3CN solution. In most cases, the receptors were stable. Anion exchange was fast, and binding constants were calculated from the NMR titration profiles. The structure of the adduct [Re(CO)3(HtBupz)3]⋅NO3 (3) was determined by X‐ray diffraction. Two pyrazole moieties are hydrogen‐bonded to one nitrate oxygen atom, and the third pyrazole moiety is hydrogen‐bonded to an oxygen atom of an adjacent nitrate, leading to infinite chains. The structure of the adduct [Re(CO)3(Hdmpz)3]BAr′4⋅acetone (4), also determined by X‐ray diffraction, showed a similar interaction of two pyrazole NH groups with the acetone oxygen atom. F− and H2PO4− deprotonate the receptors, and HSO4− decomposed 1. The structure of one of the decomposition products (5), determined by X‐ray diffraction, is consistent with pyrazole protonation and substitution by sulfate.
Versatile Coordination Chemistry towards Multifunctional Carbon Nanotube Nanohybrids
Authors: Guldi Dirk M. , Rahman G. M. Aminur , Qin Shuhui , Tchoul Maxim , Ford Warren T. , Marcaccio Massimo , Paolucci Demis , Paolucci Francesco , Campidelli Stéphane , Prato Maurizio 
Published: December 2005

AbstractDispersible single‐walled carbon nanotubes grafted with poly(4‐vinylpyridine), SWNT‐PVP, were tested in coordination assays with zinc tetraphenylporphyrin (ZnP). Kinetic and spectroscopic evidence corroborates the successful formation of a SWNT‐PVP⋅ZnP nanohybrid. Within this SWNT‐PVP⋅ZnP nanohybrid, static electron‐transfer quenching (2.0±0.1)×109 s−1 converts the photoexcited‐ZnP chromophore into a radical‐ion‐pair state with a microsecond lifetime, namely one‐electron oxidized‐ZnP and reduced‐SWNT.
Unexpected Structural Diversity in Alkali Metal Azide‐Crown Ether Complexes: Syntheses, X‐ray Structures, and Quantum‐Chemical Calculations
Authors: Brown Michael D. , Dyke John M. , Ferrante Francesco , Levason William , Ogden J. Steven , Webster Michael 
Published: December 2005

AbstractA series of alkali metal azide‐crown ether complexes, [Li([12]crown‐4)(N3)], [Na([15]crown‐5)(N3)], [Na([15]crown‐5)(H2O)2]N3, [K([18]crown‐6)(N3)(H2O)], [Rb([18]crown‐6)(N3)(H2O)], [Cs([18]crown‐6)(N3)]2, and [Cs([18]crown‐6)(N3)(H2O)(MeOH)], has been synthesised. In most cases, single crystals were obtained, which allowed X‐ray crystal structures to be derived. The structures obtained have been compared with molecular structures computed by density functional theory (DFT) calculations. This has allowed the effects of the crystal lattice on the structures to be investigated. Also, a study of the MNterminal metal–azide bond length and charge densities on the metal (M) and terminal nitrogen centre (Nterminal) in these complexes has allowed the nature of the metal–azide bond to be probed in each case. The bonding in these complexes is believed to be predominantly ionic or ion‐dipole in character, with the differences in geometries reflecting the balance between maximising the coordination number of the metal centre and minimising ligand‐ligand repulsions. The structures of the crown ether complexes determined in this work show the subtle interplay of such factors. The significant role of hydrogen bonding is also demonstrated, most clearly in the structures of the K and Rb dimers, but also in the chain structure of the hydrated Cs complex.
Electronic Structure of M(BH4)4, M: Zr, Hf, and U, by Variable Photon‐Energy Photoelectron Spectroscopy and Density Functional Calculations.
Authors: Green Jennifer C. , de Simone Monica , Coreno Marcello , Jones Aled , Pritchard Helen M. I. , McGrady G. Sean 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Crystal Growth, Structural, and Property Studies on a Family of Ternary Rare‐Earth Phases Ln2InGe2 (Ln: Sm, Gd, Tb, Dy, Ho, Yb).
Authors: Tobash Paul H. , Lins Daniel , Bobev Svilen , Lima Ana , Hundley Michael F. , Thompson Joe D. , Sarrao John L. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Reactivity of W3Te4+7 Clusters and Chalcogen Exchange in the M3Q7 (M: Mo, W; Q: S, Se, Te) Cluster Family.
Authors: Sokolov Maxim N. , Abramov Pavel A. , Gushchin Artem L. , Kalinina Irina V. , Naumov Dmitry Y. , Virovets Alexander V. , Peresypkina Eugenia V. , Vicent Cristian , Llusar Rosa , Fedin Vladimir P. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Enantioselective Allylation of Ketones Catalyzed by Chiral In(III)‐PYBOX Complexes.
Authors: Lu Jun , Hong Mei‐Ling , Ji Shun‐Jun , Teo Yong‐Chua , Loh Teck‐Peng 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Remarkable Effect of Bases on the Catalytic Radical Addition of Cyanoacetate to Alkenes Using a Mn(II)/Co(II)/O2 Redox System.
Authors: Kagayama Takashi , Fuke Takahiro , Sakaguchi Satoshi , Ishii Yasutaka 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
(Z)‐Selective Cross‐Dimerization of Arylacetylenes with Silylacetylenes Catalyzed by Vinylideneruthenium Complexes.
Authors: Katayama Hiroyuki , Yari Hiroshi , Tanaka Masaki , Ozawa Fumiyuki 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Iridium‐Catalyzed Enantioselective Pauson—Khand‐Type Reaction of 1,6‐Enynes.
Authors: Shibata Takanori , Toshida Natsuko , Yamasaki Mitsunori , Maekawa Shunsuke , Takagi Kentaro 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Highly Active Phosphine‐Free Carbene Ruthenium Catalyst for Cross‐Metathesis of Acrylonitrile with Functionalized Olefins.
Authors: Bai Chen‐Xi , Zhang Wen‐Zhen , He Ren , Lu Xiao‐Bing , Zhang Zhi‐Qiang 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Morita—Baylis—Hillman‐Type Adducts by Unprecedented Reaction of 1‐Phenyl‐2‐(trimethylsilyl)acetylene with Aromatic Aldehydes Catalyzed by Quaternary Ammonium Fluorides Derived from Cinchonine.
Authors: Yoshizawa Kazuhiro , Shioiri Takayuki 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 4,6‐Dinitrobenzo[b]furans from 1,3,5‐Trinitrobenzene.
Authors: Dutov Mikhail D. , Vatsadze Irina A. , Vorob'ev Sergei S. , Shevelev Svyatoslav A. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Mild and Efficient Method for Halogenation of 3,5‐Dimethyl Pyrazoles by Ultrasound Irradiation Using N‐Halosuccinimides.
Authors: Stefani Helio A. , Pereira Claudio M. P. , Almeida Roberta B. , Braga Rodolpho C. , Guzen Karla P. , Cella Rodrigo 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Nitroimidazoles. Part 1. An Unexpected Reactivity During the Cyclization of 3‐(4‐Amino‐1‐benzyl‐2‐ethyl‐1H‐imidazol‐5‐ylsulfanyl)‐propionic Acid Methyl Ester.
Authors: Al‐Soud Yaseen A. , Al‐Masoudi Najim A. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Regioselective Alkylation of Thiazolylsulfonamides: Direct and Efficient Synthesis of 3‐Alkylthiazolidene Derivatives.
Authors: Masuda Naoyuki , Yamamoto Osamu , Fujii Masahiro , Ohgami Tetsuro , Moritomo Ayako , Kontani Toru , Kageyama Shunji , Ohta Mitsuaki 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Clean Method for Producing 4‐Aryl‐7,7‐dimethyl‐5‐oxo‐3,4,5,7,8‐hexahydrocoumarin in Aqueous Media
Authors: Jin Tong‐Shou , Wang Ai‐Qing , Cheng Zhao‐Li , Zhang Jian‐She , Li Tong‐Shuang 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Solid‐State Condensation Reactions Between Aldehydes and 5,5‐Dimethyl‐1,3‐cyclohexanedione by Grinding at Room Temperature.
Authors: Jin Tong‐Shou , Zhang Jian‐She , Wang Ai‐Qing , Li Tong‐Shuang 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Discovery of N‐(3‐{4‐[(3‐Fluorobenzyl)oxy]phenoxy}propyl)‐2‐pyridin‐4‐ylacetamide as a Potent and Selective Reverse NCX Inhibitor.
Authors: Kuramochi Takahiro , Kakefuda Akio , Yamada Hiroyoshi , Ogiyama Takashi , Taguchi Taku , Sakamoto Shuichi 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Novel Reactions of 6,7‐Dimethoxy‐3,4‐dihydroisoquinoline and 3,4‐Dihydro‐β‐carboline with Dipolarophiles.
Authors: Nyerges Miklos , Dancso Andras , Bitter Istvan , Blasko Gabor , Toeke Laszlo 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Reaction of Enaminones with Aminopyrazoles: Synthesis, Structures and Bioactivities of 7‐Aryl‐3‐cyano‐2‐substituted Pyrazolo[1,5‐a]pyrimidines.
Authors: Wen Li‐Rong , Wang Shu‐Wen , Li Ming , Yang Hua‐Zheng 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A New Approach to the Facile Synthesis of Mono‐ and Disubstituted Quinazolin‐4(3H)‐ones under Solvent‐Free Conditions.
Authors: Salehi Peyman , Dabiri Minoo , Zolfigol Mohammad Ali , Baghbanzadeh Mostafa 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Nonnucleoside HIV‐1 Reverse‐Transcriptase Inhibitors. Part 5. Synthesis and anti‐HIV‐1 Activity of Novel 6‐Naphthylthio HEPT Analogues.
Authors: Sun Guang‐Fu , Chen Xu‐Xiang , Chen Fen‐Er , Wang Yue‐Ping , De Clercq Erik , Balzarini Jan , Pannecouque Christophe 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Zirconium Mediated Total Synthesis of Crinitol (Xb), 9‐Hydroxyfarnesoic Acid (XV), 9‐Hydroxyfarnesol (Xa), 9‐Hydroxysargaquinone (XII) and the Selectively‐Protected Aglycone of Moritoside and Euplexide A (XIV).
Authors: Dixon Sally , Gordon George J. , Whitby Richard J. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Palladium‐Catalyzed Intramolecular γ‐Lactam Formation of an Aryl Halide and an Enolate: Synthesis of Isoindolobenzazepine Alkaloids, Lennoxamine, 13‐Deoxychilenine, and Chilenine.
Authors: Honda Toshio , Sakamaki Yoshiaki 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Enantioselective Synthesis and Absolute Configuration of the Natural threo‐3‐Chloro‐1‐(4‐hydroxy‐3‐methoxyphenyl)propane‐1,2‐diol.
Authors: Wang Qian , He Kan Kan , Li Yun Zhong , Li Da Wei , Li Ying , Hou Zi Jie 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Study of Porous Silicon Nanostructures as Hydrogen Reservoirs.
Authors: Lysenko Vladimir , Bidault Fabrice , Alekseev Sergei , Zaitsev Vladimir , Barbier Daniel , Turpin Christophe , Geobaldo Francesco , Rivolo Paola , Garrone Edoardo 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Inadequacies of the current American Joint Committee on cancer staging system for prostate cancer
Authors: Taylor Sarah H. , Merriman Kelly W. , Spiess Philippe E. , Pisters Louis 
Published: December 2005

AbstractBACKGROUNDTwo major objectives of the American Joint Committee on Cancer (AJCC) staging system are to ensure appropriate treatments for patients and to determine prognosis. AJCC stage for distant prostate cancer includes patients with regional lymph node involvement. In the current study, the authors assessed whether patients with lymph node involvement and patients with distant metastasis, as determined using the Surveillance, Epidemiology, and End Results (SEER) staging system, had similar treatment and survival duration and, thus, were grouped together appropriately in the AJCC system.METHODSIn total, 4141 patients were selected from The University of Texas M. D. Anderson Cancer Center's Tumor Registry who initially had registered at the center between January 1, 1982, and December 31, 2001, with a diagnosis of prostate cancer; had received no treatment before presentation; and had received treatment at the center. Patients with unknown stage and patients with any other primary malignancies were excluded. Descriptive analyses of demographic and disease variables were performed. Using SEER stage groups, survival analyses and Cox proportional hazards regression analyses were performed.RESULTSTreatments differed between patients with lymph node involvement and patients with distant metastasis. The median survival was 134 months for patients with lymph node involvement and 42 months for patients with distant metastasis. When these 2 groups were combined, as in the AJCC scheme, the median survival was 86 months.CONCLUSIONSThe treatment and median survival of patients with lymph node involvement differed substantially from those of patients with distant metastasis. The current AJCC scheme for prostate cancer appeared to be inappropriate when considering its purpose, and the authors concluded that it should be revised. Cancer 2006. © 2005 American Cancer Society.
Dysplastic nodules frequently develop into hepatocellular carcinoma in patients with chronic viral hepatitis and cirrhosis
Authors: Kobayashi Masahiro , Ikeda Kenji , Hosaka Tetsuya , Sezaki Hitomi , Someya Takashi , Akuta Norio , Suzuki Fumitaka , Suzuki Yoshiyuki , Saitoh Satoshi , Arase Yasuji , Kumada Hiromitsu 
Published: December 2005

AbstractBACKGROUNDAdvances in imaging technology have enhanced the detection of small nodular lesions during the course of chronic liver disease.METHODSBetween 1995 and 2002, the authors examined 154 consecutive patients with small hepatic nodules without hepatocellular carcinoma (HCC) over a median duration of 2.8 years. The median size of these nodules was 14 mm (range, 7–40 mm). The initial histopathologic diagnosis included high‐grade dysplastic nodule (HGDN) (n= 13), low‐grade dysplastic nodule (LGDN) (n= 42), and regenerative nodule (RN) (n= 99).RESULTSA total of 29 (18.8%) nodules developed into HCC during the observation period. Cumulative HCC development rates at the first, third, and fifth year were 46.2%, 61.5%, and 80.8% for HGDN; 2.6%, 30.2%, and 36.6% for LGDN; and 3.3%, 9.7%, and 12.4% for RN, respectively. The rate of HCC development was significantly higher in the HGDN group than for other types (P< 0.001). Multivariate analysis disclosed that histopathologic diagnosis (P< 0.001) and findings on computed tomographic arterial portography (CT‐AP) (P= 0.004) were significantly associated with future HCC development. The hazard ratios of HGDN and LGDN were 16.8 (95% confidence interval [CI], 6.19–45.6) and 2.96 (95% CI, 1.20–7.31), respectively. A decrease in portal blood flow also showed a significantly high hazard ratio of 3.04 (95% CI, 1.42–6.50). Approximate annual development rate to HCC was 20% in patients with HGDN and 10% in LGDN.CONCLUSIONHGDN should be considered a precancerous lesion when it appears during follow‐up of chronic viral hepatitis or cirrhosis. Reduced portal blood flow in the nodule on computed tomography‐AP is also an important predictor for development of hepatocellular carcinoma. Cancer 2006. © 2005 American Cancer Society.
Surgery by consultant gynecologic oncologists improves survival in patients with ovarian carcinoma
Authors: Engelen Mirjam J. A. , Kos Henrike E. , Willemse Pax H. B. , Aalders Jan G. , de Vries Elisabeth G. E. , Schaapveld Michael , Otter Renee , van der Zee Ate G. J. 
Published: December 2005

AbstractBACKGROUNDConsultant gynecologic oncologists from the regional Comprehensive Cancer Center assisted community gynecologists in the surgical treatment of patients with ovarian carcinoma when they were invited. For this report, the authors evaluated the effects of primary surgery by a gynecologic oncologist on treatment outcome.METHODSThe hospital files from 680 patients with epithelial ovarian carcinoma who were diagnosed between 1994 and 1997 in the northern part of the Netherlands were abstracted. Treatment results were analyzed according to the operating physician's education by using survival curves and univariate and multivariate Cox regression analyses.RESULTSPrimary surgery was performed on 184 patients by gynecologic oncologists, and on 328 patients by general gynecologists. Gynecologic oncologists followed surgical guidelines more strictly compared with general gynecologists (patients with International Federation of Gynecology and Obstetrics [FIGO] Stage I–II disease, 55% vs. 33% [P = 0.01]; patients with FIGO Stage III disease, 60% vs. 40% [P = 0.003]) and more often removed all macroscopic tumor in patients with FIGO Stage III disease (24% vs. 12%; P = 0.02). When patients were stratified according to FIGO stage, the 5‐year overall survival rate was 86% versus 70% (P = 0.03) for patients with Stage I–II disease and 21% versus 13% (P = 0.02) for patients with Stage III–IV disease who underwent surgery by gynecologic oncologists and general gynecologists, respectively. The hazards ratio for patients who underwent surgery by gynecologic oncologists was 0.79 (95% confidence interval [95%CI], 0.61–1.03; adjusted for patient age, disease stage, type of hospital, and chemotherapy); when patients age 75 years and older were excluded, the hazards ratio fell to 0.71 (95% CI, 0.54–0.94) in multivariate analysis.CONCLUSIONSThe surgical treatment of patients with ovarian carcinoma by gynecologic oncologists occurred more often according to surgical guidelines, tumor removal more often was complete, and survival was improved. Cancer 2006. © 2005 American Cancer Society.
Phase II study of a protracted irinotecan schedule in children with refractory or recurrent soft tissue sarcoma
Authors: Bisogno Gianni , Riccardi Riccardo , Ruggiero Antonio , Arcamone Giampaolo , Prete Arcangelo , Surico Gianmarco , Provenzi Massimo , Bertolini Patrizia , Paolucci Paolo , Carli Modesto 
Published: December 2005

AbstractBACKGROUNDIrinotecan (CPT‐11) is a novel antineoplastic agent that takes effect by inhibiting topoisomerase I. The Italian Soft Tissue Sarcoma (STS) Committee performed a multiinstitutional Phase II study to evaluate its effect on STS.METHODSOver a 2‐year period between 2002 and 2004, 32 heavily pretreated patients were administered 60‐minute infusions of irinotecan at 20 mg/m2/day, for 5 days a week, for 2 consecutive weeks. The courses were repeated every 4 weeks for at least 2 courses, unless there were signs of toxicity or disease progression. Thirty patients, 13 with peripheral primitive neuroectodermal tumor (PNET), 12 with rhabdomyosarcoma (RMS), 3 with desmoplastic small round cell tumor (DSRCT), and 2 with other STS were evaluable for response.RESULTSA total of 79 cycles were delivered. The main regimen‐related toxicity was diarrhea, occurring in 58% of cycles with 9 episodes graded as 3 or 4. Grade 3–4 neutropenia was recorded in 10% of cycles. The overall response rate was 23% (2 complete remissions + 5 partial remissions of 30 patients), 38% for PNET and 16% for RMS. In addition, 4 minor responses were noted.CONCLUSIONSAs a single agent in the treatment of recurrent and refractory STS, irinotecan administered on a daily ×5 ×2 schedule revealed a noteworthy response rate in a population of heavily pretreated patients, especially in the subset of patients with PNET. Its hematologic toxicity profile warrants further investigation in association with other myelotoxic agents. Cancer 2006. © 2005 American Cancer Society.
Prognosis in transplant‐eligible patients with agnogenic myeloid metaplasia
Authors: Dingli David , Schwager Susan M. , Mesa Ruben A. , Li Chin Yang , Tefferi Ayalew 
Published: December 2005

AbstractBACKGROUNDAllogeneic hematopoietic stem cell transplantation is potentially curative in agnogenic myeloid metaplasia (AMM) but is associated with substantial mortality and morbidity that necessitates accurate identification of patients in whom benefit outweighs risk. The current study describes the natural history of AMM in transplant‐eligible patients and proposes a new prognostic scoring system that favorably compares with other established models.METHODSPatients diagnosed with AMM before the age of 60 years and seen at Mayo Clinic were identified and the diagnosis confirmed. Relevant demographic, clinical, and laboratory characteristics were abstracted, and the impact of various parameters on overall survival (OS) was evaluated with univariate and multivariate analyses.RESULTSA cohort of 160 patients with AMM is described. OS was 78 months. Multivariate analysis identified a hemoglobin level of <10 g/dL, white blood cell count of either <4 or >30 × 109/L, platelet count of <100 × 109/L, presence of constitutional symptoms, and hepatomegaly as independent predictors of inferior survival. The first 3 complete blood count‐based parameters were combined into a new scoring system that resulted in median survivals of 155, 69, and 24 months in the presence of 0, 1, or ≥2 adverse features. The chi‐square value for the new model was 80.6 compared with 51.4, 48.4, and 43.7 for the models by Dupriez, Cervantes, and Visani, respectively.CONCLUSIONSA new scoring system based on blood count at the time of diagnosis can adequately stratify by risk transplant‐eligible patients with AMM and can accurately identify high‐risk as well as intermediate‐risk disease. The new system displayed a stronger discriminative value, between risk categories, compared with currently existing prognostic models. Cancer 2006. © 2005 American Cancer Society.