bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of quantitative trait loci for lodging and related agronomic traits in soybean (Glycine max [L.] Merr.)
Authors: Chen Bo , Chai Cheng , Duan Mingming , Yang Ximeng , Cai Zhandong , Jia Jia , Xia Qiuju , Luo Shilin , Yin Lu , Li Yunxia , Huang Nianen , Ma Qibin , Nian Hai , Cheng Yanbo 
Published: March 2024

Abstract

Background:Lodging, a crucial agronomic trait linked to soybean yield, poses a significant challenge in soybean production. Nevertheless, there has been less research on soybean lodging compared to other important agronomic traits, hindering progress in breeding high-yield soybeans. Our goals were to investigate lodging, pinpoint quantitative trait loci (QTL) linked to lodging, and forecast potential candidate genes linked to this trait. To achieve this, we employed a recombinant inbred line (RIL) population derived from a cross between Guizao 1 and B13 (GB) across various environments.
Results:The lodging score of the RIL population was found to be significantly positively correlated with flowering time, maturity time, plant height, number of main stem nodes, stem diameter, and internode length, with correlation coefficients ranging from 0.457 to 0.783. A total of 84 QTLs associated with soybean lodging and related traits were identified using the GB population. The contribution of phenotypic variance ranged from 1.26% to 66.87%, with LOD scores ranging from 2.52 to 69.22. Additionally, within these QTLs, a stable major QTL associated with lodging was newly discovered in the GB population. Out of the 10 major QTLs associated with other related traits, nine of them were situated within the qLD-4-1interval of the major lodging score locus, displaying phenotypic variations ranging from 12.10% to 66.87%. Specific alterations in gene expression were revealed through the analysis of resequencing data from the two parental lines, potentially indicating their significant roles in lodging. Subsequently, it was determined through qRT-PCR that three genes are likely to be the major genes controlling soybean lodging.
Conclusions:This study's findings offer valuable insights into the genetic underpinnings of soybean lodging resistance traits. By comprehending the potential genetic factors associated with lodging, this research lays the groundwork for breeding high-yield soybeans with improved lodging resistance.
Classification and Diagnosis of Heart Disease Using Machine Learning
Authors: Mohsen‬‏ ‪Ayedh Abdulaziz , Naoufel Kharroubi , Alrashahy Taher , Noaman Somia 
Published: March 2024

Abstract
Heart disease is a common and serious disease that causes many deaths around the world. The study aims to explore the use of machine learning techniques in classifying and diagnosing heart diseases and to develop a system capable of diagnosing and classifying different types of heart diseases using machine learning techniques. A number of algorithms commonly used in healthcare, such as Naive Bayes model, SVM, k-nearest neighbor (k-NN), and others, were reviewed. The study points out the importance of the quality of the data used in the database to obtain an accurate and reliable diagnosis. Data were collected from patient records in hospitals and clinics, analyzed and compared with previous relevant studies. Clinical decision assistance software has been used to help make medical decisions based on patient information. Positive results have been achieved that confirm the effectiveness of using machine learning techniques in diagnosing heart diseases. These technologies have shown the potential to improve the accuracy and efficiency of diagnosis, leading to improved patient outcomes and reduced health burdens. It also concluded the need to develop effective diagnostic tools and enhance the prevention of heart disease. The study is an important foundation for healthcare professionals and doctors working in the field of cardiology, as the techniques used can help them better understand and diagnose conditions and improve patient care.
Impact of Adenotonsillectomy on Obesity Risk: A Case-Control Study in Paediatric Population
Authors: Morreale Chiara , Musolino Gianluca , Rosa Sara La , Bresesti Ilia , De Bernardi Francesca , Agosti Massimo 
Published: March 2024

Abstract
Childhood obesity is one of the most important problem in our society with a multifactorial aetiology. Adenoidectomy and tonsillectomy are one of the most frequent paediatric surgeries. Primary aim of our retrospective study is to evaluate the possible relationship between tonsillectomy and/or adenoidectomy and the subsequent development of childhood obesity.
METHODS: 267 children (3-17 years) were enrolled and n=9 are excluded because of their elevated BMI before surgery or their therapy. Case group: 158 children (98 male (M), 60 female (F)) with essential obesity (≥97°P) and no evidence of obesity complications at the first endocrinology visit (T0). Control group=100 non obese children (37 M, 63 F) with subclinical hypothyroidism. We collect anthropometric parameters (height, weight, BMI) at T0, pre and post-surgery.
RESULTS: ENT surgery was more frequent in case group than control one (n=46 vs n=7, p-value <0,0001). The mean period between the date of surgery and the onset of obesity was 3,5 years (6 months-10 years). The Odds ratio (OR) between risk to develop obesity after ENT surgery is five times higher in the case group than the control one, (OR 5.5 p-value <0,0001).
CONCLUSION: The surgical exposure seems to be a risk factor for obesity development. Actually, the weight gain might be related to improvement of lifestyle and olfactory-taste perception.
Level of Evidence: Level III, case-control analytic trial
ID1 protein inhibitor depresses low-oscillating shear stress-mediated EndMT and atherosclerosis by Snail and Wnt/β-catenin signalling pathways
Authors: Jun Qiu , Yang Xi , Wang Bingyu , Sun Xinyi , Li Youhong , Lian Jiangfang , Zhou Jianqing 
Published: March 2024

Abstract
The lateral pressure exerted by blood on the vessel wall, called low oscillating shear stress(OSS), destroys the endothelial cell barrier function through a process called EndMT and promotes the occurrence of atherosclerosis. The specific mechanism by which OSS regulates EndMT is still unclear. Inhibitor of differentiation 1 (ID1) is controlled by shear stress as an essential force-sensitive factor, and little is known about the effect of ID1 on EndMT in OSS-mediated atherosclerosis. This study investigated the impact of ID1 inhibitors on OSS-mediated EndMT in ApoE−/− mice and TGF-β1-induced human aortic endothelial cells (HAECs). First, we found that the expression of ID1 was down-regulated. At the same time, EndMT and plaque formation occurred in the ligated left common carotid artery (OSS) compared with the unligated right common carotid artery. Then, our results showed that the ID1 inhibitor AGX51 attenuated EndMT in atherosclerosis plaques in OSS mice. However, in vitro studies show that ID1 is upregulated in TGF-β1-treated HAECs and induces EndMT.sh-ID1 or AGX51 to inhibit the EndMT process and restore the migratory ability of endothelial cells. Furthermore, ID1 overexpression promoted the occurrence of EndMT.In addition, inhibition of ID1 may inhibit OSS-induced EndMT by regulating EndMT-specific transcription factors Snail and Wnt/β-catenin signalling pathway in vivo and in vitro by Immunohistochemistry and Western blot. These results suggest that ID1 inhibitors regulate the occurrence and development of low oscillating shear stress-mediated EndMT and atherosclerosis by Ctrlling Snail and Wnt/β-catenin signalling pathways.
Synthetic high b-value FOCUS-MUSE diffusion-weighted imaging in identifying early-stage cervical cancer
Authors: Mei Wancui , Tang Qian , Sang Ling , Chen Wen , Li Chengcheng , Wang Sai , Zhou Qiqi , Liu Weiyin , Xu Lin 
Published: March 2024

Abstract

Background
Early diagnosis of cervical cancer based on FIGO stage is essential for treatment strategies, we aimed to explore the classifying ability of synthetic high-b-value FOCUS-MUSE DWI in cervical cancer FIGO stage including image quality and diagnostic efficiency.
Methods
55 patients with cervical cancer and 33 volunteers were prospectively recruited. All patients and volunteers underwent three DWI sequences (FOCUS-MUSE DWI with a 13b protocol: b = 0, 25, 50, 75, 100, 150, 200, 400, 600, 800, 1000, 1200, 1500s/mm2 and 5b protocol: b = 0, 100, 400, 800, 1500s/mm2, the FOCUS DWI with the same 5b protocol. Two experienced radiologists conducted subjective and objective evaluation on 5 sets of images (sFOCUS-MUSE DWIb=800, sFOCUS-MUSE DWIb=1500, syFOCUS-MUSE DWI13b,1500, syFOCUS-MUSE DWI5b,1500, syFOCUS DWI5b,1500) and also measured ADC values. Paired T-test or Wilcoxon signed rank test were used to compare image quality and ADC values, and ROC curve was used to analyze diagnostic efficiency.
Results
The high-b-value syFOCUS-MUSE DWI5b/13b,1500 had higher subjective and objective image quality than sFOCUS-MUSE DWIb=1500 (P < 0.05). Compared with syFOCUS DWI5b,1500 and sFOCUS-MUSE DWIb=800, syFOCUS-MUSE DWI5b,1500 had better overall image quality and lesion conspicuity (P < 0.05). syFOCUS-MUSE DWI5b,1500 derived syADCmean, syADCmaximum and syADCminimum had equivalent AUCs to those using sFOCUS-MUSEb=800 and sFOCUS-MUSEb=1500, but superior to those using syFOCUS5b,1500.
Conclusions
On 3.0T MR scanner, syFOCUS-MUSE DWI provided higher overall image quality and lesion clarity than sFOCUS-MUSE DWI and syFOCUS DWI. 5b-protocol synthetic high-b-value FOCUS–MUSE DWI greatly shortened the scan time and histogram-derived syADC values (syADCmean, syADCmaximum, syADCminimum) offered more reliable diagnostic performance on cervical cancer with different FIGO stage than those of sFOCUS-MUSE and syFOCUS.
Solving Multi-Agent Games on Networks
Authors: Vaknin Yair , Meisels Amnon 
Published: March 2024

Abstract
Multi-agent games on networks (GoNs) have nodes that represent agents and edges that represent interactions among agents. Binary GoNs are composed of 2-Players games on each of their edges. Non binary GoNs have games that are played by all agents in each neighborhood.Solutions to games on networks are stable states (i.e., pure Nash equilibria), and in general one is interested in efficient solutions (i.e., of high social welfare).Incentives, in the form of side payments among agents, are known to promote increased-efficiency stable states.
This study addresses the multi-agent aspect of games on networks - a system of multiple agents that compose a game and seek a solution. The agents playing the game are assumed to be strategic and the present study proposes an iterative distributed algorithm that lets the agents interact (i.e., negotiate) in neighborhoods in a process that guarantees the convergence of any multi-agent game on network to a stable state.The proposed algorithm treats the game as a repeated social choice action that takes place in one neighborhood at a time. A truthful enforcing mechanism is integrated into the process, collecting agents' valuations and computing incentives on the fly while eliminating strategic behavior. This method - the TECon algorithm - is proven to converge to solutions that are at least as efficient as the initial state, for any game on network.A specific version of the algorithm is given for the class of public goods games, where the main properties of the algorithm are guaranteed even when the strategic agents playing the game consider their possible future valuations when interacting.This opens an interesting new research direction on application-specific derivatives of TECon that, similarly to the case of public goods games, may lead to solutions of greater efficiency. An extensive experimental evaluation on randomly generated games on networks demonstrates that the TECon algorithm outperforms former solving methods on several classes of games on networks.
A Glutamine metabolism-related genes prognosis biomarker for predicting prognosis in colorectal carcinoma
Authors: Ma Na , Zhang Siming , Yu Sihan , Shen Rong , Zhang Chencheng , Diao Xun , Wang Qinghui , Wu Zhijun , Liu Jibin 
Published: March 2024

Abstract

Background
Colorectal cancer (CRC) is one of the most common types of tumor in the gastrointestinal tract worldwide. Amino acid metabolism is closely associated with malignant tumor development, infiltration, metastasis and recurrence. More studies are needed to understand the relationship between glutamine metabolic profile and prognosis of colorectal cancer.
Methods
In our study, we obtained transcriptomic and related clinical information data of CRC patients from The Cancer Genome Atlas (TCGA) database. Consensus clustering analysis was used to classify CRC patients into various molecular subtypes and identify differential expression of genes related to immunity and glutamine metabolism. We applied univariate and multivariate COX regression and lasso regression analyses to construct a risk assessment model incorporating four genes related to glutamine metabolism, and the CRC samples were categorized into high- risk and low-risk groups, and the correlation between the risk model scores and TME, immune cell infiltration, and cellular mutations was investigated. Finally, we validated the correlation of ADIPOQ using immunohistochemistry in colorectal cancer tumor tissues. In addition, this study was externally validated using the GSE39582 dataset from the GEO database.
Results
By consistent cluster analysis, we identified two different molecular subtypes. It was also found that different GMRG subtypes were associated with patients' clinicopathologic features, prognosis and TME cell infiltration characteristics. Meanwhile, a predictive model on the basis of the GMRGS risk score was developed and the validity of the predictive ability of the model was verified in internal and external datasets. Furthermore, in terms of immune infiltration and cellular mutations, we observed significant variability between high and low risk groups.
Conclusion
Our study identified four glutamine metabolism-related genes affecting TME, clinicopathological features, immune landscape, and prognosis-related prediction of CRC, and these findings in our study will better understand the mechanisms by which reprogramming of glutamine metabolism is associated with the developmental progression of CRC and will facilitate to improve the treatment of tumors.
Extracardiac Manifestations Fail to Predict the Severity of Cardiac Phenotype in Children and Young Adults with Marfan Syndrome
Authors: John Sheba , Young Luciana T. , Lacro Ronald V. , Hoskoppal Arvind , Ou Zhining , Presson Angela , Johnson Joyce T. , Andrade Lauren , Minich L. LuAnn , Menon Shaji 
Published: March 2024

Abstract

We performed a secondary analysis of the Pediatric Heart Network Marfan Trial public-use database to evaluate associations between extracardiac features and cardiac and aortic phenotypes in study participants. Aortic aneurysm phenotype was defined as aortic root Z-score ≥ 4.5, aortic root growth rate ≥ 75th percentile, aortic dissection, and aortic surgery. Severe cardiac phenotype was defined as aortic dissection, aortic Z-score ≥4.5, aortic valve surgery, at least moderate mitral regurgitation, mitral valve surgery, left ventricular dysfunction, or death. Extracardiac manifestations were characterized by specific organ system involvement and by a novel aggregate extracardiac score that was created for this study based on the original Ghent nosology. Logistic regression analysis compared aggregate extracardiac score and systems involvement to outcomes. Of 608 participants (60% male), the median age at enrollment was 10.8 years (interquartile range: 6, 15.4). Aortic aneurysm phenotype was observed in 71% of participants and 64% had severe cardiac phenotype. On univariate analysis, skeletal (OR: 1.95, 95% CI: 1.01, 3.72; p = 0.05), skin manifestation (OR: 1.62, 95% CI: 1.13, 2.34; p = 0.01) and aggregate extracardiac score (OR: 1.17, 95% CI: 1.02, 1.34; p = 0.02) were associated with aortic aneurysm phenotype but were not significant in multivariate analysis. There was no association between extracardiac manifestations and severe cardiac phenotype. Thus, the severity of cardiac manifestations in Marfan syndrome was independent of extracardiac phenotype and aggregate extracardiac score. Severity of extracardiac involvement did not appear to be a useful clinical marker for cardiovascular risk-stratification in this cohort of children and young adults with Marfan syndrome.
Short-term outcomes of 47 selective laparoscopic lymph node dissection for rectal cancer: A Retrospective Study
Authors: xue xiajuan , Guo Yincong , Lin Shuijie , Zeng Qunzhang 
Published: March 2024

Abstract
Purpose: The aim of this study is to analyze the safety, feasibility and short-term oncology outcomes of selective laparoscope lateral lymph node dissection(LLND) with total mesorectal excision(TME) surgery.
Methods: Between December 2019 and May 2023, LLND with TME surgery was performed in 47 selected patients with advanced rectal cancer. Surgical complications and 2-year oncology survival outcomes were analyzed in the study.
Results: All 47 procedures were technically successful without the need for conversion to open surgery. The mean operation time was 200.6 minutes (range, 135-321 minutes) and mean estimated blood loss was 92.9 ml (range, 10-2000 ml). The most common postoperative complications were anastomotic(8.5%,n=4), ileus (6.4%, n=3), chyle leakageleakage (4.3%, n=2). Lateral pelvic lymph node metastases(LPNM) was found in 19 (40.4%) patients. When divided into LNP positive or negative groups, there were no significant impact on the OS (94.4%vs100%, Log rank p=0.596) and LFRS(76.7%vs89.6%, Log rank p=0.210) , except DFS (58.3%vs90.2%,Log rank p=0.005). Subgroup analysis showed that there was similar short-tem survival outcomes between pN+ group and internal iliac metastasis group(Log rank p of OS,LFRS,DFS were all＞0.05). LRFS and DFS in obturator or external iliac metastasis group were worse than those in internal iliac metastasis group when the follow-up time was extended(Log rank p of LFRS, DFS were 0.05, 0.063 , respectively).
Conclusion: Selective laparoscopy LLND for rectal cancer are safety and feasibility, and its complications are manageable. Oncology survival outcomes for LPNM limited to the internal iliac are similar to pN+ stage , therefor it should be treated positively.
Anatomical, chemical, physical and mechanical properties of E. urophylla× grandis and E. globulus at different ages and heights in Yunnan of China
Authors: Li Chunping , Tian Kun , Su Xinlong , Li Yuan , Du Guanben , Zhan Hui , Wang Changming , Wan Hui 
Published: March 2024

Abstract
In order to make full use of Eucalyptus resources in Yunnan and to realize the oriented cultivation of Eucalyptus plantations and high-value utilization of Eucalyptus for wood composites, this paper analyzed the change pattern of basic wood properties and characteristics including the wood anatomical features, chemical components, physical and mechanical properties, as well as X-ray diffraction of 6–9 years old E. urophylla×grandis 3229 and E. globulus. The results showed that the cellulose content, crystallinity and hot water extractives of Eucalyptus decreased with wood age, while the lignin and hemicellulose content showed the opposite trend; pH value was positively correlated with wood height and negatively correlated with wood age. The basic density of E. urophylla×grandis and E. globules was 0.46 ~ 0.54 g/cm3, belonging to medium-low density wood. The dimensional stability and bengding strength of E. globulus were higher than those of E. urophylla×grandis; the compressive strength of E. urophylla×grandis was grade 5 (95.45 ~ 113.54 MPa) and its hardness was grade 2–3(The end hardness of 9 year reaches 5357.97 MPa.). The study showed that E. urophylla×grandis over 7 to 8 years and E. globulus over 6 year had diameters and mechanical properties that meeting the requirement of Chinese industrial timber standards.
Two-stage robust reserve coordinated operation based on real-time price mechanism
Authors: Deng Huiqiong , Hui Wu , Liang Zhiwei , Tong Zhe , Shen Junfu 
Published: March 2024

Abstract

In order to cope with the impacts of uncertainty factors on the reliability and economy of system operation, a two-stage robust reserve optimization model is proposed to take into account the real-time price day-ahead and intraday. The proposed model consists of two phases: the first phase is the day-ahead decision-making phase, which improves the flexibility of grid operation by establishing a demand response model based on the load classification under real-time price; and the second phase is the intraday decision-making phase, which takes into account the uncertainty of the wind - photovoltaic power and the failure of the transmission line in order to improve the robustness of the grid in coping with the uncertainties. The day-ahead decision-making is a deterministic optimization problem, which is solved by a linear programming problem, while the intra-day decision-making is an adaptive robust optimization problem, which is solved by using the Strong Dyadic Theory (SDT) method. By combining the power data of wind and photovoltaic fluctuation intervals and load demand of a regional power grid, a simulation model is constructed to verify that the proposed robust model is effective in optimizing the reserve capacity of the system operation under multiple uncertainties, reducing the scheduling cost of the system in the worst scenario, and ensuring the safe and reliable operation of the system.
Efficasy of pancreaticojejunostomy of the pancreatic stump during distal or central pancreatectomy
Authors: Hirashita Teijiro , Fujinaga Atsuro , Nagasawa Yuiko , Orimoto Hiroki , Amano Shota , Kawamura Masahiro , Kawasaki Takahide , Kawano Yoko , Masuda Takashi , Endo Yuichi , Inomata Masafumi 
Published: March 2024

Abstract

Background: A stapler is usually used for transection and closure of the pancreas in distal pancreatectomy (DP) or central pancreatectomy (CP). When the pancreas is transected to the right of the portal vein, it is difficult to use a stapler and clinically relevant postoperative pancreatic fistula (CR-POPF) frequently occurs. We report on the efficacy of pancreaticojejunostomy (PJ) of the pancreatic stump for patients in whom stapler use is difficult.
Methods: Patients who underwent DP or CP were enrolled in this study. The pancreas was usually transected by a stapler, and ultrasonic coagulating shears (UCS) were used depending on the tumor situation. When using UCS, hand-sewn closure or PJ was performed for the pancreatic stump. The relationship between clinicopathological factors and the methods of pancreatic transection and closure were investigated.
Results: In total, 164 patients underwent DP or CP, and the pancreas was transected with a stapler in 150 patients and UCS in 14 patients. The rate of CR-POPF was higher and the postoperative hospital stay longer in the stapler group than in the UCS group. PJ of the pancreatic stump, which was performed for 7 patients, did not worsen intraoperative factors. CR-POPF was not seen in these 7 patients, which was significantly less than that with hand-sewn closure.
Conclusions: PJ of the pancreatic stump during DP or CP reduces CR-POPF compared with hand-sewn closure and may be useful especially when the pancreas is transected to the right of the portal vein.