bluuebunny/crossref_metadata_2025_split huggingface dataset:
AUSSCHEIDUNG VON 17-KETOSTEROIDEN, 17-KETOGENEN STEROIDEN UND ÖSTROGENEN BEIM MENSCHEN NACH GABEN VON 17α-ÄTHYNYL-19-NOR-TESTOSTERON-ESTERN
Authors: Breuer H. , Dardenne U. , Nocke W. 
Published: December 2008

ABSTRACT
The excretion of 17-ketosteroids (17-KS) and 17-ketogenic steroids (17-KGS) has been studied in 7 postmenopausal women and 4 men before and during administration of 17α-ethynyl-19-nor-testosterone-acetate (ANTA). In one 34 year old oophorectomized patient the excretion of 17-KS and 17-KGS was followed after intramuscular injection of 17α-ethynyl-19-nor-testosterone-oenanthate (ANTO). Administration of ANTA (20, 60, 100 or 200 mg/day) did not cause any significant alteration in the excretion of 17-KS and 17-KGS. After intramuscular injection of 100 or 200 mg ANTO no change in the excretion of 17-KS and 17-KGS was observed. In one postmenopausal woman and in 2 men the administration of 60 or 100 mg ANTA/day led to a pronounced increase in the excretion of urinary oestrogens. The increase in the oestradiol fraction was due to the formation of 17α-ethynyl-17β-oestradiol. The highest values were found in the oestrone fraction; by applying various micromethods, oestrone was isolated and identified by its melting point. The excretion of oestriol remained unchanged during the administration of ANTA.
GONADAL DYSGENESIS: THE GENETIC SIGNIFICANCE OF UNUSUAL VARIANTS
Authors: Stewart John S. S. 
Published: December 2008

ABSTRACT
Three chromatin negative cases of gonadal dysgenesis are presented. The first patient is an example of pure gonadal dysgenesis which is probably more common than has been recognised.
The second patient is of short stature and suffers also from diabetes mellitus and extreme deuteranomaly. The association with diabetes mellitus is not unexpected and the pedigree of colour blindness vindicates nuclear sexing as an index of X chromosomal constitution.
The third patient has short stature, neck webbing and had menstruated regularly and apparently normally for six years.
Evidence is presented for a genetic aetiology of gonadal dysgenesis. The most likely mechanism is some form of chromosomal aberration.
THE EFFECT OF TESTOSTERONE ON THE SPERMATOGENESIS OF THE COMMON FROG, RANA TEMPORARIA
Authors: van Oordt P. G. W. J. , Basu S. L. 
Published: December 2008

ABSTRACT
Testosterone pellets have been implanted into the dorsal lymph sac of common frogs (Rana temporaria) at three different stages of the spermatogenetic cycle.
Testosterone appears to cause complete inhibition of the multiplication divisions of the spermatogonia. It has no effect on the development of the spermatocytes and spermatids and may even slightly accelerate this process. The mode of action of testosterone, and its probable role in the regulation of the spermatogenetic cycle is discussed.
ÉTUDE VOLUMÉTRIQUE DE L'INTERRÉNAL ANTÉRIEUR AU COURS DE LA SMOLTIFICATION DE SALMO SALAR L.
Authors: Olivereau Madeleine 
Published: December 2008

ABSTRACT
The interrenal of fish represents the embryological and functional homologue of mammalian adrenal cortex.
The planimetric evaluation of interrenal area, dispersed in cephalic lymphoid kidney, shows, during the »smoltification« of Salmon, Salmo salar L., a marked and significative hypertrophy of this glandular tissue. The absolute and relative volume of interrenal is increased of about 100 % in the smolt, migrating form, versus the parr, sedentary form. The blood supply exhibits a great development. The glandular hypertrophy and hyperaemia are concomitant with nuclear and nucleolar hypertrophy and with a gradual vacuolisation of the cells, facts previously described.
These results are discussed in connection with preceeding datas obtained on pituitary gland and thyroid in Salmo salar L. during »smoltification«. They are characterized by a definite secretory and excretory activity of fuchsinophilic cells of the middle glandular region of the pituitary gland, with a statistically significative increase of their percentage, and by a functional activation of the thyroid gland.
They are confronted with experimental and clinical papers on vertebrate endocrinology. The histological and biochemical observations, in mammals as in Salmon, suggest a synergic relationship among various hormones: Corticotrophin, somatotrophin, thyroid function and adrenocortical activity.
CHROMATOGRAPHY OF THE 17-KETOGENIC STEROIDS IN THE DIAGNOSIS AND CONTROL OF CONGENITAL ADRENAL HYPERPLASIA
Authors: Hill Eileen E. 
Published: December 2008

ABSTRACT
A method for the fractionation of the urinary 17-ketogenic steroids with no oxygen grouping at C11 and those oxygenated at C11, is applied to the clinical problems of congenital adrenal hyperplasia. In normal children the mean ratio of the non-oxygenated to oxygenated steroids is 0.24. In childrern with congenital adrenal hyperplasia the ratio is 2.3. The reason for this difference in ratio is discussed. The changes in ratio found under stimulation of the adrenal gland with exogenous or endogenous corticotrophin and the suppression with cortisone therapy are studied. This test can be applied to isolated samples of urine, a major advantage in paediatric practice, and can be carried out in routine laboratories. It is found to be reliable in the diagnosis and sensitive in the control of congenital adrenal hyperplasia.
ÜBER DIE BILDUNG VON ENDOMETRIALEN KÖRNCHENZELLEN BEI KASTRATINNEN UNTER HORMONEINFLUSS
Authors: Hellweg G. , Ferin J. , Ober K. G. 
Published: December 2008

ABSTRACT
65 endometrial biopsies from castrated women who had received either natural or artificial sex hormone therapy were studied microscopically. Attention was paid to various histologic criteria, especially to the number of endometrial granulocytes (»K« cells, KZ). The following was obtained: The »K« cells are completely absent when no hormone substitution therapy is given. They were also lacking when the castrated patients were treated only with oestrogens, even if the dose given was ten-times that found in women during the reproductive ages. In contrast, the »K« cells developed from the endometrial stromal cells only under influence of progesterone, usually appearing first 8–10 days after the administration of the gestagen. The »K« cells were demonstrable in the number corresponding to a normal secretory phase only then, when the oestrogen-progesterone dosage ratio had induced a fully-developed secretory change, as measured by the usual histologic criteria. With an overdosage of oestrogen the »K« cells were either absent or were very sparse. Contrarily, an overdosage of progesterone had no influence on their number. The development of endometrial glands does not always entirely parallel that of the stroma in castrated patients following hormone therapy. A more exact indicator for the proper dose for the production of a secretory phase by hormone therapy seems to be the number of »K« cells in the endometrial stroma.
LONG TERM EFFECT OF CORTICOTROPHIN, CORTISONE, AND GROWTH HORMONE ON THE TISSUE EOSINOPHILS IN RAT'S STOMACH
Authors: Räsänen Toimi 
Published: December 2008

ABSTRACT
The effect of corticotrophin, cortisone and somatotrophin, administered once daily for periods of 10 or 12 days, on the tissue eosinophilia of the lamina propria in the glandular stomach of male rats has been studied. There was a highly significant decrease in tissue eosinophilia (P < 0.001) under the influence of corticotrophin and cortisone.
In neither series did somatotrophin exercise any clearly recognizable effect on the tissue eosinophilia.
GESTOGENS IN CORPUS LUTEUM OF CATTLE
Authors: Kristoffersen John 
Published: December 2008

ABSTRACT
By means of chromatographic and spectrophotometric methods progesterone and a substance closely similar to 20β-hydroxy-pregn-4-ene-3-one has been detected in luteal tissue from non-pregnant and pregnant cows. In 21 animals quantitative measurements based on a method giving an average net recovery of 56 per cent showed that in pregnancy the average progesterone content in the corpus luteum reached a maximum in the third to fifth month, with low values before and after this period. For 6 nonpregnant cows, the average value was 20.2 μg/g tissue, which is considerably higher than previous values reported in the literature. The relation between these findings and the bovine dependence on a functional corpus luteum in pregnancy is discussed, and it is pointed out that more information about the metabolism of progesterone in cattle is highly desirable.
PREGNANE-2α,17α,20α-TRIOL, PREGNANE-3α,17α,20α-TRIOL, AND RELATED STEROIDS
Authors: Cox R. I. 
Published: December 2008

ABSTRACT
The occurrence, metabolic formation, estimation and significance of the urinary steroids 5β-pregnane-3α,17α,20α-triol, pregn-5-ene-3β,17α,20α-triol, 5β-pregnane-3α,17α,20α-triol-11-one and 5β-pregnane-3α,1 1β,17α,20α-tetrol is reviewed. The isolation from and estimation in urine of these 17,20-dihydroxy-20-methyl steroids and some of their epimers is detailed. The significance of the estimation of this group of steroids, especially of pregnanetriolone and pregnanetriol, in the study and diagnosis of adrenal hyperplasia and adrenal tumours derives from their being formed only from 21-deoxy intermediates in cortisol biosynthesis. The main pathways of metabolic formation of the compounds are correlated from published work. A number of methods suitable for urinary estimation at the microgram level of various members of the group of steroids are noted and discussed.
EINE NEUE METHODE ZUR QUANTITATIVEN BESTIMMUNG VON PREGNANDIOL IM URIN
Authors: Lipp G. 
Published: December 2008

ABSTRACT
A new method is described for the quantitative analysis of pregnandiol (5β-pregnane-3α,20α-diol) in urine. A marked increase in specificity is obtained by a combination of adsorption and paperchromatography. The sensitivity of the method allows of exact determinations of excretion of pregnandiol below 1 mg/d. By the new method it was possible to measure the excretion of pregnandiol in newborn infants, and the method is recommended for the exact determination of pregnandiol in urine of children, men and women in the follicular phase of the menstrual cycle. The method is suitable as a clinical routine analysis.
EFFECT OF ALDOSTERONE IN A CASE OF HYPOALDOSTERONISM
Authors: Hökfelt Bernt , Skanse Bengt 
Published: December 2008

ABSTRACT
A patient previously described by the present authors as having selective hypoaldosteronism has been studied more extensively with special reference to the effect of aldosterone. Additional evidence has also been obtained in support of the original diagnosis of selective hypoaldosteronism. With the patient on a constant sodium intake, aldosterone intramuscularly or intravenously in a dose of 500 to 1000 μg a day was followed by retention of sodium and chloride, gain in body weight, increase in systolic blood pressure, and a rise in the serum sodium. Potassium excretion was increased throughout the period of aldosterone administration. The serum potassium showed a slight decrease. Similar effects were noted on administration of fluorohydrocortisone.
EFFECT OF SEX HORMONES ON THE DEVELOPMENT OF THE RAT VAGINA
Authors: Forsberg John-Gunnar 
Published: December 2008

ABSTRACT
The material for this investigation comprises 46 female rat embryos given various hormone treatments. The embryos have been sectioned serially and stained with a combined haematoxylin-eosin-orange-G stain.
In the ventral cloacal remnant an increased growth takes place in the area of Bartholin's rudiments after testosterone treatment.
The author points out that with the single doses used it has been possible to study the sensitivity to sex hormones of the different phases in the development of the rat vagina.
PRECOCIOUS PUBERTY IN RATS WITH HYPOTHALAMIC LESIONS
Authors: Gellert Ronald J. , Ganong William F. 
Published: December 2008

ABSTRACT
Eight female rats with electrolytic lesions involving the arcuate nucleus in the posterior tuberal region of the hypothalamus matured significantly earlier than unoperated controls. Lesions placed in the anterior hypothalamus, mammillary body, hippocampus, cortex and thalamus of immature female rats had no effect on the age at which vaginal opening and first oestrus occurred.
CHANGES IN SERUM PROTEIN-BOUND IODINE, SERUM CHOLESTEROL AND THE RADIOACTIVE IODINE EXCRETION TEST IN THYROTOXICOSIS TREATED WITH RADIOACTIVE IODINE
Authors: Hakkila Riitta , Lamberg B.-A. , Hernberg C. A. 
Published: December 2008

ABSTRACT
The changes in serum protein-bound iodine and serum cholesterol and in the radioactive iodine excretion test were studied in 144 cases of thyrotoxicosis (98 cases with toxic nodular goitre, 34 with diffuse toxic goitre and 12 with a »non-palpable« thyroid). It is concluded that changes in PBI and cholesterol are usually well correlated with changes in the clinical condition. Measurement of these indices of thyroid function at specified intervals after treatment will therefore give an adequate picture of the clinical course in most cases.
In a few cases, however, some discrepancies were observed, notably hypothyroid parameters with euthyroidism in an intermediate stage before final stabilization of the clinical condition occurred. These cases may represent temporary subclinical hypothyroidism.
The excretion of radioactive iodine may be elevated in the early phases after treatment, reflecting the radiation injury to the thyroid. In later phases the excretion may remain low, indicating a small thyroidal iodine pool with a rapid turn-over. Hence, the measurement of excretion of radioactive iodine (or the thyroid uptake) after treatment is not very valuable as a thyroid function test but affords other valuable information on the state of the thyroid gland.
OVARIENIMPLANTAT IN MILZ UND HYPOPHYSEKTOMIE
Authors: Fels E. , Foglia V. G. 
Published: December 2008

ABSTRACT
In the hypophysectomized rat the intrasplenic ovarian graft (auto- and homoiograft) always becomes atrophic and never reaches any further development. Hypophysectomy has such an influence on the ovary, that this gland, after transplantation into the spleen of a castrated rat, takes only in 16% of the cases (the ovarian graft from and into non-hypophysectomized rats takes in 70 to 100 %). Hypophysectomy in rats with an already developed ovarian tumour, produces tumour regression.
This facts prove that the hypophysis is the organ responsible for tumourigenesis in the intrasplenic ovarian graft. It is now necessary to prove that the hypophyseal gonadotrophins are the hormones which produce the proliferative and blastomatous changes of the intrasplenic ovary.
In a future paper we hope to put forth more confirmative data regarding this hypothesis.
EFFECT OF OVARIECTOMY ON VASCULAR REACTIONS
Authors: Zsotér Thomas , Revesz Clara , Bandermann Lothar 
Published: December 2008

ABSTRACT
Vascular reactivity, estimated on the basis of peripheral blood flow responses to intraarterial noradrenaline, »Priscoline« and »Pitressin« infusions, was studied in dogs.
Ovariectomy had little effect on these vascular responses. The duration however of the effect of noradrenaline and »Priscoline« became prolonged. Vascular reaction was examined in two other groups of animals receiving »Premarin« or progesterone after ovariectomy.
THE ACTION OF CORTICOSTEROIDS ON THE RENAL REABSORPTION OF CALCIUM
Authors: Laake Helge 
Published: December 2008

ABSTRACT
The tubular reabsorption of Ca has been studied by means of Ca clearance investigations in 16 patients with non endocrine diseases during long term therapy with small doses of corticosteroids. The tubular reabsorption of Ca was reduced in 7 patients. This is attributed to the anti-anabolic action of the corticosteroids on the cells of the tubules. Ca reabsorption became normal on administration of anabolic steroids.
CORTISOL AND CORTISONE CONTENT OF AMNIOTIC FLUID FROM DIABETIC AND NON-DIABETIC WOMEN
Authors: Baird C. W. , Bush I. E. 
Published: December 2008

ABSTRACT
Cortisol and cortisone were estimated in ten samples of amniotic fluid from normal mothers at term, and in five samples from diabetic mothers taken at 36–38 weeks during artificial induction or at Caesarean section. The steroids were estimated by a chromatographic procedure via their acetates. Small but definite quantities of both steroids were found in all the samples examined. The concentration of cortisol was 2.6 ± 0.32 μg/100 ml in the normal fluids, and 2.2 ± 0.37 μg/100 ml in the diabetics' fluids. The concentration of cortisone was 1.3 ± 0.14 μg/100 ml in normal, and 1.4 ± 0.19 μg/100 ml in the diabetics' fluids. The differences between the normal and diabetics' fluids were not significant.
Contrary to some previous work it is concluded that small quantities of these steroids are regularly present in normal amniotic fluid. The possible role of these steroids in the aetiology of foetal abnormality in diabetic pregnancy is discussed.
THYROTROPHIN AS AN AID IN RADIOIODINE TREATMENT
Authors: Einhorn Jerzy , Larsson Lars-Gunnar 
Published: December 2008

ABSTRACT
Fifteen hyperthyroid patients with low thyroidal uptake were treated with radioiodine following thyrotrophin premedication. Twelve of them had large nodular goiters and eight had known exposure to large doses of iodine. A single injection of thyrotrophin given about 18 hours before the radioiodine, produced an increase of the 24-hours uptake which facilitated radioiodine treatment. The same experience was made in six patients with persisting hyperthyroidism 3-6 months after radioiodine treatment and with low thyroid uptake of radioiodine. In three euthyroid patients with a low uptake it was also possible to increase the thyroid uptake significantly by injection of thyrotrophin before 131I therapy. The indications for radioiodine treatment were cardiac disease or tracheal compression by large nodular goiter.
HYPOGLYCAEMIA IN THE PRESENCE OF MASSIVE FIBROSARCOMA (MESENCHYMOMA)
Authors: Pedersen Jørgen , Lund Flemming , Ringsted Jørgen 
Published: December 2008

ABSTRACT
An elderly woman exhibited severe hypoglycaemic attacks. Whipple's triad and characteristic electroencephalographic changes were present. After removal of a large retroperitoneal fibrosarcoma, the hypoglycaemia ceased. On the basis of this case and of 11 reported in the literature, the authors emphasize the following characteristics: (1) The tumour is located retroperitoneally, more rarely intrathoracically, just above the diaphragm. (2) The tumours are very large, ranging in weight from 700 to 4700 g. (3) The tumours appear to be fibrosarcomas of low-degree malignancy; histologically they do not resemble insulomas. (4) The pancreas is normal.
Insulin was not demonstrable in the tumour in the present case. It is suggested that perhaps the tumour produces an unknown substance exerting an insulin-like activity.
THE EFFECT OF GROWTH HORMONE ALONE OR IN COMBINATION WITH CORTICOTROPHIN OR TOGETHER WITH THE COMBINATION OF OESTRADIOL-17β AND TESTOSTERONE PROPIONATE, IN ADULT RATS HYPOPHYSECTOMIZED AT THE TIME OF VAGINAL CORNIFICATION
Authors: Grattarola Renzo 
Published: December 2008

ABSTRACT
Adult rats of the Long-Evans strain hypophysectomized at the time of vaginal cornification were treated with bovine pituitary growth hormone alone or in combination with varying doses of ACTH for 28 days. It was observed that growth hormone alone maintained the uterine weight at a level above that of the controls, and, in the ovaries, stimulated the thecal cells of the atretic follicles. These cells also were stimulated by periodate-treated growth hormone, which is considered to be completely free from any ICSH contamination. With the combination of growth hormone and ACTH, the uterine weight was higher than it was with growth hormone alone, and the uterine mucosa showed epithelial cells with vacuolated cytoplasm and proliferation of stromal cells. In the ovaries, the thecal cells of the atretic follicles were hypotrophic. In the absence of the adrenal glands, the uterine picture produced by the combination of these 2 hormones was no longer observed, and the thecal cells of the atretic follicles were again stimulated, as they were with growth hormone alone.
The injection of oestradiol-17β (0.1 μg daily) in combination with testosterone propionate 2 mg daily) for 28 days to another group of rats, again hypophysectomized at the time of vaginal cornification, induced a cystic glandular hyperplasia in the uterus. The uterine epithelial cells, after this combined treatment, were abnormal, with enlarged nuclei and loss of cellular polarity. When growth hormone was injected together with
* Present address: Istituto per lo studio e la cura dei tumori, Milano (Italy).
the oestradiol-17β and testosterone propionate, a normal cellular pattern was observed in the uterine epithelium and the uterine weight was considerably higher than that obtained with the combination of oestradiol and testosterone propionate without the growth hormone.
IN VITRO UPTAKE OF RADIOACTIVE 131I LABELLED L-TRIIODOTHYRONINE BY HUMAN ERYTHROCYTES AS AN INDEX OF THYROID FUNCTION
Authors: Woldring M. G. , Bakker A. , Doorenbos H. 
Published: December 2008

ABSTRACT
The red cell triiodothyronine uptake technique as used in our hospital is described. Incubation time is of almost no importance. The temperature during incubation should be 37° C. Further improvement of the technique is obtained when all blood samples are brought up to 40 % haematocrit prior to incubation.
Clinical results are discussed. It is yet too early to give a definite assessment of its clinical value, but it is definitely superior to the measurement of the BMR.
A STUDY ON THE METABOLISM OF CALCIUM IN THE HYPERADRENOCORTICAL SYNDROME
Authors: Molinatti G. M. , Camanni F. , Olivetti M. 
Published: December 2008

ABSTRACT
An investigation of the calcium metabolism has been carried out in 16 patients with Cushing's syndrome of various types and degrees, before and after either uni- or bilateral adrenalectomy, or implantation of the pituitary gland with 90 Y, and in 2 cases of adrenogenital syndrome.
In all the cases of Cushing's syndrome a disturbance of calcium metabolism was observed. A negative trend of calcium metabolism was frequently found, both in cases with and without radiographic signs of osteoporosis. This was revealed by an increase of the urinary calcium, both spontaneously and after a calcium tolerance test. However, an opposite metabolic condition was found in 3 cases. A rapid change of the calcium metabolism, consisting of a marked decrease of both spontaneous and induced calciuria to values below the normal range, together with a normalisation of the hormonal picture was always recorded after the surgical treatment.
A normal or positive calcium metabolism was found in the 2 cases of adrenogenital syndrome.
The relationship between the metabolic and hormonal picture is thoroughly discussed.
HUMAN URINARY GONADOTROPHINS ASSAYED BY DIFFERENT RESPONSES IN THE SAME ANIMAL
Authors: Brown P. S. 
Published: December 2008

ABSTRACT
Selected human urinary gonadotrophins were assayed against one another using various measures of response in the same immature female mice. Intact or hypophysectomized animals were used and in some experiments the results of hypophysectomy were checked in complete serial sections. Extracts from the urine of two subjects with Turner's syndrome were compared. In intact mice, the relative potency judged by the ovarian response differed from that shown by the uterine response and the 95 % fiducial limits of the two estimates did not overlap. When the mice were hypophysectomized, one extract became much less potent while the other did not.
Similar differences were shown in the response of intact mice to urinary extracts from two subjects with Klinefelter's syndrome. There was a marked disparity between the relative potencies shown by the uterine response and by the incidence of vaginal opening.
Similar differences were not shown between the responses to different extracts from the urine of normal postmenopausal women, but these extracts were known to differ little in quality.
The results are interpreted in terms of qualitative differences between human urinary gonadotrophins.