bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study of the protease inhibitory activity component of SARS-CoV-2 3CL in Bletilla striata
Authors: Yang Yuyu , Zhang Fei , Liu Shihan , Jin Wenfang , Shao Qianshan , Li Chunxiao , Fan Baolei 
Published: March 2024

The protease Mpro (referred to as 3CLpro or 3CL protease) is a cysteine protease that is highly conserved in coronavirus and is indispensable for viral replication. Because there is no homologous protein for MPro in the human body, SARS-CoV-2 3CL protease is an ideal target against coronavirus. Bletilla striata (Reich. Bf.) is a well-known form of Traditional Chinese Medicine and can exert many pharmacological effects, including hemostasis, anti-microbial and anti-virus activities. Our preliminary screening showed that the n-butanol component of a methanol extract of B. striata exhibited potent inhibitory activity against SARS-CoV-2 3CL protease (58.82% at 200 μg/mL). In this study, we biologically evaluated ten isolated chemical compounds from B. striata and investigated the inhibitory activities of its constituents on SARS-CoV-2 3CL protease. Following bioactivity-guided fractionation, four bibenzyls (1, 4, 6 and 7), three phenols (5, 8 and 9), two anthraquinones (2 and 3) and one glucosyloxybenzyl 2-isobutylmalate (10) were isolated and evaluated for their ability to inhibit SARS-CoV-2 3CL protease by fluorescence resonance energy transfer (FRET) analysis. The binding mode between compounds and enzymes was investigated by molecular docking and Saturation Transfer Differences - nuclear magnetic resonance (STD-NMR). Moreover, Pleiobibenzynin B (7), Blestritin B, Gymconopin D (4), Physcion, 3′-O-methyl dioscin III (6), Gastrodin (8) and caffeic acid (5) all exhibited inhibitory activity against 3CL protease in vitro. The four bibenzyls (1, 4, 6 and 7) exhibited good inhibitory activity against SARS-CoV-2 3CL protease (7.37–39.86 μM). These findings identify potential new inhibitors against SARS-CoV-2 3CL protease, which offers promising lead compounds for the development of novel anti-SARS-CoV-2 drugs.
Case report: when art is faced with brain surgery: acute change in creative style in a painter after glioma resection
Authors: Duffau Hugues 
Published: March 2024

BackgroundStrong interactions between art and health are well-known. While advances in brain surgery resulted in an improved preservation of sensorimotor, visuospatial, language and cognitive functions, creative abilities received less attention. However, creativity may represent a critical issue to resume an optimal quality of life, especially in artists. Here, a unique case of sudden change in creative style in a painter who underwent glioma resection is described. This prompts to explore further creative thinking and its clinical implications in routine practice.MethodsA 36-year-old right-handed woman experienced inaugural seizures, allowing the discovery of a right frontal lesion. The patient was a professional painter and did not complain about any decline in her creativity. The preoperative neurological examination was normal.ResultsSurgery was achieved with a maximal tumor resection through a frontal lobectomy. A WHO grade II oligodendroglioma was diagnosed. A regular surveillance was performed without adjuvant oncological treatment. The patient did not exhibit postoperative functional deterioration and she returned to normal activities including painting during 15 years. Remarkably, even though her creative activity was judged by the patient herself to be rich and satisfying, her style drastically changed from surrealism and mysticism to cubism whereas she was not able to explain why.ConclusionThis is the first report of acute modification of the painting style following frontal lobectomy for a low-grade glioma, supporting that brain resective surgery may impact creativity. While neglected for many decades, this complex human ability should be evaluated more regularly in neurosurgical practice, particularly in artists.
In vivo bistatic dual-aperture ultrasound imaging and elastography of the abdominal aorta
Authors: van Hal Vera H. J. , de Hoop Hein , van Sambeek Marc R. H. M. , Schwab Hans-Martin , Lopata Richard G. P. 
Published: March 2024

Introduction: In this paper we introduce in vivo multi-aperture ultrasound imaging and elastography of the abdominal aorta. Monitoring of the geometry and growth of abdominal aortic aneurysms (AAA) is paramount for risk stratification and intervention planning. However, such an assessment is limited by the lateral lumen-wall contrast and resolution of conventional ultrasound. Here, an in vivo dual-aperture bistatic imaging approach is shown to improve abdominal ultrasound and strain imaging quality significantly. By scanning the aorta from different directions, a larger part of the vessel circumference can be visualized.Methods: In this first-in-man volunteer study, the performance of multi-aperture ultrasound imaging and elastography of the abdominal aortic wall was assessed in 20 healthy volunteers. Dual-probe acquisition was performed in which two curved array transducers were aligned in the same imaging plane. The transducers alternately transmit and both probes receive simultaneously on each transmit event, which allows for the reconstruction of four ultrasound signals. Automatic probe localization was achieved by optimizing the coherence of the trans-probe data, using a gradient descent algorithm. Speckle-tracking was performed on the four individual bistatic signals, after which the respective axial displacements were compounded and strains were calculated.Results: Using bistatic multi-aperture ultrasound imaging, the image quality of the ultrasound images, i.e., the angular coverage of the wall, was improved which enables accurate estimation of local motion dynamics and strain in the abdominal aortic wall. The motion tracking error was reduced from 1.3 mm ± 0.63 mm to 0.16 mm ± 0.076 mm, which increased the circumferential elastographic signal-to-noise ratio (SNRe) by 12.3 dB ± 8.3 dB on average, revealing more accurate and homogeneous strain estimates compared to single-perspective ultrasound.Conclusion: Multi-aperture ultrasound imaging and elastography is feasible in vivo and can provide the clinician with vital information about the anatomical and mechanical state of AAAs in the future.
Bounded rationality in healthcare: unraveling the psychological factors behind patient satisfaction in China
Authors: Qian Yu , Wang Xiaohe , Huang Xianhong , Li Jinwen , Jin Chen , Chen Jie , Sha MengYi 
Published: March 2024

IntroductionPatient satisfaction is a crucial metric to gauge the quality of medical services, but the psychological factors influencing patient satisfaction remain insufficiently explored.MethodsThis study examines these psychological factors by applying the theory of bounded rationality to 1,442 inpatients in Hangzhou, China, whose data were collected using a questionnaire. One-way ANOVA, correlation analysis, and hierarchical regression were used to analyze patient satisfaction and its associated factors. Additionally, the path analysis of the structural equation model revealed the mechanisms behind the key psychological factors that influenced patient satisfaction.ResultsMedical risk perception, the social cognition of the medical environment, and social desirability bias had significant positive impacts on patient satisfaction. By contrast, negative emotions had a significant negative impact on patient satisfaction. Notably, patients’ negative emotions had both a suppressive effect and a positive moderating effect on the relationship between medical risk perception and patient satisfaction. Similarly, social desirability bias had a suppressive effect on the correlation between the social cognition of the medical environment and patient satisfaction, albeit with a negative moderating effect.DiscussionThese results suggest that when evaluating and improving patient satisfaction, accounting only for the factors that directly influence medical service quality is insufficient, as the indirect and moderating effects of patients’ negative emotions and the social cognition of the medical environment must also be considered. Medical service providers should thus address patients’ negative emotions, establish good doctor–patient relationships, optimize service environments, provide managers with medical risk education and training on negative emotions, and prioritize patient-centered care. Additionally, the government and relevant health departments should optimize medical policies, enhance fairness and accessibility, and create a positive social cognitive environment through public education and awareness campaigns.
Postnatal depression in British mothers of African and Caribbean origin: a randomised controlled trial of learning through play plus culturally adapted cognitive behaviour therapy compared with psychoeducation
Authors: Jidong Dung Ezekiel , Ike Tarela Juliet , Murshed Maisha , Francis Christopher , Mwankon Shadrack Bitrus , Jidong John Ezekiel , Pwajok Juliet Yop , Nyam Pam Patrick , Husain Nusrat 
Published: March 2024

BackgroundOne in every three women worldwide experiences postnatal depression after childbirth, with long-term negative consequences on their children. The mainstream mental healthcare provision for British mothers of African/Caribbean origin is mostly unsuccessful due to a lack of culturally appropriate care.MethodsThe study adopts a mixed-methods randomised controlled trial (RCT) design. A 12-session (60 minutes each) of online Learning Through Play plus Culturally adapted Cognitive Behaviour Therapy (LTP+CaCBT) intervention was employed for treating postnatal depression in comparison with psychoeducation (PE). Participants aged 19–53 were screened for depression using the Patient Health Questionnaire (PHQ-9). N=130 participants who scored &gt;5 on PHQ-9 were randomised into LTP+CaCBT (n=65) or PE (n=65) groups. N=12 focus groups (LTP+CaCBT, n=6; PE, n=6) and n=15 individual interviews (LTP+CaCBT, n=8; PE, n=7) were conducted, transcribed verbatim and analysed.ResultsSatisfaction with intervention (LTP+CaCBT, 72.9%; PE, 65.2%); retention rates (LTP+CaCBT, 91%; PE, 71%); reduction in postnatal depression was higher in LTP+CaCBT on PHQ-9 Md=1.00 with z= -4.046; compared to PE, Md=1.00 with z= -1.504. Both groups showed reduced levels of anxiety on GAD-7 with no significant difference. Emerging themes from the qualitative findings showed increased positive moods, reduced worries about parenting difficulties and the facilitative role of remote intervention.ConclusionsLTP+CaCBT intervention is culturally appropriate and acceptable and reduces postnatal depression in British mothers of African/Caribbean origin. A fully powered RCT is recommended to evaluate the clinical and cost-effectiveness of LTP+CaCBT, including the child’s outcomes compared with routine treatment as usual.Clinical trial registrationwww.ClinicalTrials.gov, identifier NCT04820920.
Film dressings from Thai mango seed kernel extracts versus nanocrystalline silver dressings in antibacterial properties
Authors: Hasatsri Sukhontha , Jantrapanukorn Bajaree 
Published: March 2024

Introduction: The extract from the Mango Seed Kernel (MSK) has been documented to exhibit antibacterial activity against Gram-positive and Gram-negative bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa. This suggests that biomaterials containing MSK extract could be a viable alternative to conventional wound treatments, such as nanocrystalline silver dressings. Despite this potential, there is a notable gap in the literature regarding comparing the antibacterial effectiveness of MSK film dressings with nanocrystalline silver dressings. This study aimed to develop film dressings containing MSK extract and evaluate their antibacterial properties compared to nanocrystalline silver dressings. Additionally, the study aimed to assess other vital physical properties of these dressings critical for effective wound care.Materials and methods: We prepared MSK film dressings from two cultivars of mango from Thailand, ‘Chokanan’ and ‘Namdokmai’. The inhibition-zone method was employed to determine the antibacterial property. The morphology and chemical characterization of the prepared MSK film dressings were examined with scanning electron microscopy (SEM) and Fourier-Transform Infrared Spectroscopy (FTIR), respectively. The absorption of pseudo-wound exudate and water vapor transmission rate (WVTR) of film dressings were evaluated.Results: The results showed that 40% of MSKC film dressing had the highest inhibition zone (20.00 ± 0.00 mm against S. aureus and 17.00 ± 1.00 mm against P. aeruginosa) and 20%, 30%, and 40% of MSKC and MSKN film dressings had inhibition zones similar to nanocrystalline silver dressing for both S. aureus and P. aeruginosa (p &gt; 0.05). In addition, all concentrations of the MSK film dressings had low absorption capacity, and Chokanan MSK (MSKC) film dressings had a higher WVTR than Namdokmai MSK (MSKN) film dressings.Conclusion: 20%, 30%, and 40% of MSK film dressing is nearly as effective as nanocrystalline silver dressing. Therefore, it has the potential to be an alternative antibacterial dressing and is suitable for wounds with low exudate levels.
Morphological Changes In Wesakin Village Along The Edge Of "Uwe" River Jayawijaya Regency Papua Mountains Province Indonesia
Authors: Soni Aprianto , YM Hardiyanti 
Published: March 2024

Wesakin Village, Wouma District, is an area located on the banks of the " Uwe" river. Rivers are very important for the
survival of the people living in the village. The " Uwe" river should be preserved but the current situation is the opposite. The
preservation of the “ Uwe” river has received little attention from the government, whether in terms of transportation facilities,
residential facilities or infrastructure in accelerating regional development. Wesakin Village has been one of the areas
affected by natural disasters since in the last 5 years, the impact of this phenomenon resulted in damaged infrastructure. This
research uses qualitative methods, while data collection techniques in this research include observation, interviews,
documentation and literature study. The results of this research show that there are morphological changes in the residential
area on the banks of the “ Uwe” river, which used to be just an ordinary river bank, but as time goes by, there is residential
development where the banks of the " Uwe" river, settlements are now starting to become disorganized due to natural disasters
such as landslides and flash floods. which once affected Wesakin Village. There are two morphological changes, namely
morphological changes in community residential areas and natural morphological changes that occur in changes in the
structure of soil and rocks.
Keywords: Rivers,Jayawijaya; Landslides; Morphology; Infrastructure.
DAMPAK REKLAMASI PANTAI BAGI MASYARAKAT PESISIR DI DESA FATCEI KECAMATAN SANANA KABUPATEN KEPULAUAN SULA
Authors: Hanafi Risal Daeng , Sukmawati Annisa Mu'awanah 
Published: March 2024

Reklamasi pantai dampat menimbulkan berbagai dampak. Penelitian berlokasi di Desa Fatcei, Kecamatan Sanana, Kabupaten Kepulauan Sula, Provinsi Maluku Utara. Hingga saat ini, proyek reklamasi di pesisir Desa Fatcei belum selesai dan nampak terbengkalai sehingga berpotensi memiliki dampak tersendiri bagi kehidupan sosial ekonomi masyarakat pesisir sekitar proyek reklamasi. Penelitian bertujuan untuk nggali dampak reklamasi pantai baik dari aspek lingkungan, sosial, dan ekonomi di Desa Fatcei. Penelitian menggunakan analisis deskriptif kualitatif. Pengumpulan data dilakukan dengan wawancara menggunakan teknik purposive sampling kepada 14 informan, observasi lapangan, dan telaah dokumen. Penelitian menemukan bahwa reklamasi pantai Ibukota Sanana di Desa Fatcei memiliki dampak negatif dan positif. Sisi positif lebih dirasakan dari aspek sosial dan ekonomi. Masyarakat merasa aman dari ancaman ombak karena jarak permukiman semakin jauh dari pantai. Selain itu, juga menyediakan ruang publik baru yang dimanfaatkan untuk area olahraga, bersantai, dan interaksi sosial. Dari aspek ekonomi, masyarakat memanfaatkan lahan reklamasi untuk mendirikan usaha. Sementara itu, dampak negative reklamasi dirasakan dari aspek lingkungan karena kondisi tanggul rusak dan prasarana, seperti drainase dan persampahan di sekitar area reklamasi yang kurang terawat dan berserakan.

Kata Kunci: Desa Fatcei, Sanana, Pesisir, Reklamasi
HUBUNGAN ANTARA KEBIASAAN BERJALAN DI LINGKUNGAN TEMPAT TINGGAL DENGAN KONEKTIVITAS JALAN, KETERSEDIAAN FASILITAS DAN KARAKTERISTIK SOSIO EKONOMI – SOSIO DEMOGRAFI DI KECAMATAN SUMUR BANDUNG KOTA BANDUNG
Authors: Athallah Muhammad Nawwaf , Syafriharti Romeiza 
Published: March 2024

Kecamatan Sumur Bandung merupakan wilayah yang berada di pusat Kota Bandung. Kecamatan Sumur Bandung Mempunyai lebih banyak area komersial dibandingkan dengan area permukiman dikarekan berada di pusat Kota Bandung sebagai pusat ekonomi, pemeritahan, dan pariwisata seperti perkantoran, pusat perbelanjaan, hotel, taman dan lainnya. Penelitian ini bermaksud untuk mengetahui apakah orang yang tinggal di Kecamatan Sumur Bandung suka berjalan menuju berbagai tempat di lingkungan tempat tinggal. Dilihat dari ketersediaan fasilitas umum, kepadatan persimpangan, dan sosio ekonomi – sosio demografi. Metode yang digunakan dalam penelitian ini yaitu mengumpulkan data primer melalui penyebaran kuesioner dengan target orang yang sudah bekerja dengan total 206 responden. Setelah itu dilakukan analisis tabulasi silang (Crosstabulation) untuk mengetahui hubungan dari penelitian tersebut dengan menggunakan software SPSS 23.00. Hasil analisis crosstabulation ketersediaan fasilitas umum dan kepadatan persimpangan memiliki hubungan dengan kebiasaan berjalan di lingkungan tempat tinggal. Bisa diartikan bahwa untuk hubugngan kebiasaan berjalan dengan ketersediaan fasilitas ialah pengaruh ketersediaan fasilitas umum cenderung cukup kuat dengan kebiasaan berjalan responden di lingkungan tempat tinggal, untuk hubungan kebiasaan berjalan dengan kepadatan persimpangan bisa diartikan bahwa pengaruh tingkat kepadatan persimpangan di lingkungan tempat tinggal cenderung cukup lemah terhadap kebiasaan berjalan masyarakat di lingkungan tempat tinggal.
Analisis Competitive Advantage dalam Kajian Sektor Perekonomian Unggulan Kabupaten Bima, Provinsi NTB
Authors: Dinan Rois 
Published: March 2024

ABSTRAK
Penelitian ini berfokus untuk mengkaji sektor perekonomian yang memiliki daya saing di Kabupaten Bima. Kajian ini menggunakan basis data produk domestik regional bruto (PDRB) Kabupaten Bima pada tahun tahun 2017-2021. Dimana akan ditentukan lapangan usaha yang memiliki daya saing (competitive advantage) tertinggi dari 17 lapangan usaha yang ada. Alat analisis yang digunakan dalam menentukan lapangan usaha yang memiliki daya saing ialah analisis location quotient (LQ) dan shift-share (SS). Dalam analisisi LQ terbagi menjadi 3 tahap uji. Pertama mencari nilai static location quotient (SLQ). Kedua dilanjutkan untuk mencari nilai dynamic location quotient (DLQ). Dan yang terakhir akan dilakukan klasterisasi terhadap nilai SLQ dan DLQ yang telah diketahui. Teknik analisis static location quotient (SLQ) bertujuan untuk mengetahui posisi dari tiap-tiap sektor yang diujikan dalam terhadap sektor-sektor yang sama dalam skala regional. Sedangkan Teknik Analisis Dinamic Location Quotient (DLQ) adalah bentuk lanjutan dari SLQ dimana lebih rigit dengan menganalisis tren dari tiap-tiap sub sektor perekonomian yan diujikan. Masing-masing analisis tersebut nantinya akan menghasilkan plotting kuadran yang terbagi menjadi 4 kuadran terhadap 17 lapangan usaha dalam PDRB Kabupaten Bima yang diujikan. Pada analisis location quotient (LQ) didapatkan hasil bahwa lapanan usaha yang berada pada kuadran I (Unggulan) adalah pertanian, perikanan, kehutanan, jasa keuangan dan asuransi dan juga administrasi pemerintahan. Sedangkan pada analisis shift-share (SS) didapatkan hasil bahwa terdapat 2 lapangan usaha yang berada pada kuadran I, diantaranya adalah jasa keuangan dan informasi dan juga lapangan usaha informasi dan komunikasi. Dari kedua analisis tersebut diketahui terdapat 1 lapangan usaha yang berada pada kuadran I pada kedua analisis, yakni lapangan usaha jasa keuangan dan informasi.
Kata Kunci: Pertumbuhan ekonomi, Sektor unggulan, Daya saing, Sektor Basis, PDRB
VARIASI KETEBALAN MEDIA FILTER ARANG AKTIF TONGKOL JAGUNG TERHADAP PENURUNAN KADAR BESI (Fe) AIR BERSIH DI PT. XYZ
Authors: Fauzan Ahmad fauzan , Setyoko Sadono , Saputra Agus Somad 
Published: March 2024

Air merupakan kebutuhan pokok bagi kehidupan manusia di bumi ini. Sesuai dengan kegunaannya Air sangat penting bagi kegiatan perindustrtian, kebutuhan air bersih di industri terbagi menjadi dua yaitu air untuk produksi dan higiene sanitasi, untuk itu air bersih harus memenuhi persyaratan baik secara fisik, kimia, dan biologi. Kualitas kimia air di PT.Xyz untuk kadar Fe tidak memenuhi syarat dengan kadar Fe sebesar 1,56 mg/l, untuk itu perlu dilakukan pengolahan air dengan cara filtrasi. Filtrasi menggunakan media arang aktif tongkol jagung. Perlakuan dalam penelitian ini menggunakan variasi ketebalan media filter arang aktif tongkol jagung dengan ketebalan media filter 30 cm,40 cm, dan 50 cm, dengan tujuan untuk mengetahui perbedaan variasi media filter terhadap penurunan kadar Fe. Jenis penelitian ini yaitu eksperimen dengan desain penelitian pretest and post test without control. Teknik pengambilan sampel yang dilakukan yaitu grab sampling. Berdasarkan hasil penelitian filtrasi dengan media filter arang aktif tongkol jagung ketebalan 30 cm mampu menurunkan kadar Fe 89,04%, media filter arang aktif tongkol jagung ketebalan 40 cm mampu menurunkan kadar Fe 94,53 %, dan media filter arang aktif tongkol jagung ketebalan 50 cm mampu menurunkan kadar Fe 96,50%. Dalam penelitian ini industri dapat menggunakan media filter Arang Aktif Tongkol Jagung ketebalan 50 cm . karena berdasarkan penelitian dengan media filter Arang Aktif Tongkol Jagung ketebalan 50 cm dapat menurunkan kadar Fe sebesar 0,046 mg/l dan persentase penurunan sebesar 96,50 %.