bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studies of the incidence and significance of anti‐gamma globulin factors in the aging
Authors: Litwin Stephen D. , Singer Jacques M. 
Published: February 2007

AbstractThe anti‐gamma globulin factors which were found in 30 per cent of an aging population reacted poorly with rabbit gamma globulin and anti‐D coats. They did not contain agglutinators against Gm (a), (b), or Inv. (a). Their reactivity was like that of anti‐gamma globulin factors most frequently encountered in non‐rheumatoid disorders. Past age 70, distribution of these factors was approximately equal in those with and without evident chronic disease. However, in the group between 50 and 70, there was a much higher incidence of anti‐gamma globulin factors in subjects with various unrelated chronic conditions. The presence of these factors could not be correlated with a high incidence of hemagglutinating antibodies to thyroglobulin, an increased number of weakly positive VDRL slide tests, and an upward trend in mean gamma globulin levels found in this aging group.
Lysis of the patella due to metastatic carcinoma
Authors: Benedek Thomas G. , Clayton Mack L. , Ropes Marion W. 
Published: February 2007

AbstractPrimary neoplasms rarely originate in the patella, and metastases to the patella are even less frequent. The latter is probably explained by the scant blood supply of this sesamoid bone. Carcinomatous synovitis of one knee was an early manifestation of pulmonary carcinoma in a 67‐year‐old man. This was associated with rapid, complete lysis of the patella; no other osseous metastases were evident.
Iodinated human serum albumin (I131) localization studies of rheumatoid arthritis joints by scintillation scanning (preliminary report)
Authors: Weiss Thomas E. , Maxfield William S. , Murison Paul J. , Hidalgo John U. 
Published: February 2007

AbstractPatients with rheumatoid arthritis, osteoarthritis and gout were studied after intravenous injection of an iodinated human serum albumin I131 (IHSA) tracer. Scintillation scanning and external scintillation counting demonstrated that most arthritic joints have greater than normal localization of IHSA. The degree of localization usually paralleled the clinical involvement, but in some cases it reflected more joint activity than was evident clinically. The scans offer a graphic method of recording and studying arthritic activity in joints.
Sex hormones, bone changes and osteoarthritis in DBA/2JN mice
Authors: Sokoloff Leon , Varney David A. , Scott James F. 
Published: February 2007

AbstractSeveral possible mechanisms by which sex hormones may influence development of osteoarthritis in mice have been investigated. No relationship existed between the joint disease and mineral content of the bone. A sexual dimorphism in femur length is described for the first time. Strain differences in the effect of sex hormones on the joints of STR/1N and other strains of mice cannot be accounted for by a proposed “dyschondrogenesis.”
Use of “synovial” cell cultures in the search for virus in rheumatoid arthritis
Authors: Ford Denys K. , Oh Jang O. 
Published: February 2007

AbstractSynovial cells obtained from rheumatoid and nonrheumatoid subjects were grown in culture for periods up to 5 months. No spontaneous degeneration, suggestive of latent viral infection, was observed in the rheumatoid cultures. No significant difference could be demonstrated between multiplication of Newcastle disease virus in rheumatoid and nonrheumatoid cultures. No virusinterfering or ‐inactivating activity could be demonstrated in the culture fluid from rheumatoid synovial cultures.
A biochemical and electron microscopy study of rice bodies from rheumatoid patients
Authors: Albrecht Manfred , Marinetti Guido V. , Jacox Ralph F. , Vaughan John H. 
Published: February 2007

AbstractRice bodies (corpora oryzoidea) from rheumatoid patients were studied biochemically and by electron microscopy. The data indicate that only a relatively small portion of the rice bodies is identical to fibrin, and the bulk is composed of other fibrinlike mucoproteins and a small amount of lipids. Some lipids and neuraminic acid are located on the surface. The recurrence of rice bodies is prevented by synovectomy. Fibrous rice bodies represent an end product of synovial inflammation, proliferation, and subsequent secondary degeneration.
Book review
Authors: Stevens Jack 
Published: February 2007

AbstractTHE SURGICAL RELIEF OF PAIN IN ARTHRITIC DISEASE. By Robert A. Herfort, M.D., F.A.C.S., Attending Surgeon, St. Agnes Hospital, White Plains, New York; Attending Surgeon, Grasslands Hospital, Valhalla, New York; Consulting Surgeon, St. Barnabas Hospital, New York, New York. 89 pages, 9″ × 6″ (22.5 cm. × 15 cm.). 20 illustrations. Springfield, Ill.: Charles C Thomas, 1967. In preparation—no price listed.
Elimination of Na131I from Knee Joints with Degenerative Changes
Authors: Hernborg Jerker 
Published: February 2007

AbstractThe rate of elimination of Na131I from the knee joint was measured in 16 patients with bilateral degenerative changes and with pronounced pain on one side only. The elimination was significantly faster on the painful side. Similarly in 11 patients with painful degenerative changes after a previous fracture of the tibial condyle, the elimination of the radioisotope from the affected knee was faster than from the unaffected contralateral side. No difference in the rate of elimination was found between the two sides in 23 patients with similar but painless joint changes. The difference was believed to be due to synovitis in the painful joints.
Effects of Rheumatoid Sera on Fibroblast Proliferation and Hyaluronic Acid Synthesis
Authors: Castor C. William , Wright Deloisteen , Buckingham R. B. 
Published: February 2007

AbstractRheumatoid serum depresses synovial fibroblast proliferation in vitro and tends to enhance the rate of hyaluronic acid formed per cellular unit. Quantitatively, the observed effects are not large, are apparently not disease specific, and not related to the titer of rheumatoid factor as measured by latex fixation. An improved method for measuring acid mucopolysaccharide in tissue culture medium is described.
Stimulation of Protein–Chondroitin Sulfate Synthesis by Normal and Osteoarthritic Articular Cartilage
Authors: Jay Bollet Alfred 
Published: February 2007

AbstractA stimulatory effect on 35S uptake of rat costal cartilage by a commercial cartilage and bone marrow extract known as Rumalon was confirmed. In addition, the preparation was found to increase35S incorporation in vitro into chondroitin sulfate by human articular cartilage from the knee joint, both normal and osteoarthritic sites. This effect was limited to young rats, but no age limitation in effect was found with human cartilage. In other in vitro studies, the augmented 35S incorporation into chondroitin sulfate was found in fractions eluted from Dowex‐1 columns; a stimulation of incorporation of 3H‐serine into protein‐polysaccharide was also found in the same fraction. The effects of 3H‐serine and 35S uptake were augmented by addition of amino acids to the incubation medium and were inhibited by puromycin. In addition, increased incorporation of 3H‐uridine into RNA was observed in the same system.
Influence of human rheumatoid factor on numbers of antibody‐producing cells
Authors: Brown John C. , Epstein Wallace V. 
Published: February 2007

AbstractHuman rheumatoid factor administered to mice 24 hours after intraperitoneal injection of human IgC as antigen causes a 68 per cent reduction in the numbers of spleen cells capable of forming rosettes with IgG‐coated sheep erythrocytes. Normal human macroglobulin does not cause such an inhibition of antibody‐producing cells. The inhibitory effect of rheumatoid macroglobulin appears immunologically specific.
Liver xanthine oxidase in gouty patients
Authors: Carcassi Aldo , Marcolongo Roberto , Marinello Enrico , Riario‐Sforza Giuseppe , Boggiano Carlo 
Published: February 2007

AbstractThe activity of xanthine oxidase was studied in liver biopsy material from normal subjects and patients with primary gout. Increased enzyme activity was present in all patients with gout. The possibility that increased xanthine oxidase activity may represent a primary biochemical lesion in gout is discussed.
Beneficial effect of immobilization of joints in rheumatoid and related arthritides: A splint study using sequential analysis
Authors: Gault Sarah J. , Spyker Joan M. 
Published: February 2007

AbstractThe more actively involved upper extremity of a patient or one of equally involved upper extremities was immobilized for three weeks with a plaster of paris splint and an arm sling. In seven consecutive patients the immobilized side showed unquestionably the least amount of active joint involvement by the end of the three week period. There were no lasting undesirable side effects such as decrease of joint range of motion or loss of muscle strength of stage I, stage II, and early stage III joints.
On the mechanisms of transport and biological significance of antibodies in external secretions
Authors: Tomasi Thomas B. 
Published: February 2007

AbstractRecent evidence suggests that the antibodies present in certain external secretions are produced locally, and that the predominant immunoglobulin in these secretions appears to be γA, which is complexed to a nonimmunoglobulin glycoprotein referred to as the secretory “piece” or T chain. The secretory immunoglobulin system may be of importance in determining local flora and the resistance of mucous membranes to colonization by potentially pathogenic bacteria and viruses, and may be involved in hypersensitivity reactions on mucous surfaces as well as in certain so‐called autoimmune processes.
Synovial collagenase: Its presence in culture from joint disease of diverse etiology
Authors: Harris Edward D. , Cohen George L. , Krane Stephen M. 
Published: February 2007

AbstractClosed needle biopsy of synovium from inflamed joints yields enough tissue to detect production and/or release of collagenase from these tissues. Collagenase activity was found in synovium from 8 of 8 patients with probable rheumatoid arthritis, in 6 of 9 patients with nonrheumatoid inflammatory synovitis, and in 1 of 6 patients with degenerative joint disease. One of 2 patients with classic rheumatoid arthritis had activity in synovium regrown after synovectomy. Therefore synovial collagenase is not unique to rheumatoid arthritis.
Arthritis induced in rabbits by lysates of granulocyte lysosomes
Authors: Weissmann Gerald , Spilberg Isaias , Krakauer Kathrin 
Published: February 2007

AbstractFrom rabbit heterophile leukocytes, granules were prepared which had a high specific activity of acid hydrolases. When lysates of such granules were injected into the skin and joints of other rabbits, acute inflammation was regularly produced. Repeated intraarticular injections led to hypertrophy and hyperplasia of synovial lining cells, round cell infiltration of synovium in the vicinity of blood vessels, pannus formation, and cartilage degradation. The data suggest that escape of granule contents from lysosomes into the joint cavity is sufficient to account for proliferative and degradative changes observed in several forms of clinical and experimental arthritis.
Specificity and reactivity of cytoplasmic and nucleolar antibody in SLE sera
Authors: Watanabe Nobuo , Fisher Herbert M. , Epstein Wallace V. 
Published: February 2007

AbstractThe serum of 2 of 31 patients with SLE was found to contain an antibody to a previously unrecognized RNA‐containing antigen found in human mononuclear cell cytoplasm and nucleolus. When tissue fixed, this antibody proved capable of fixing the patient's own rheumatoid factor and human complement components. No recognizable inhibition of complement fixation by rheumatoid factor could be demonstrated by the fluorescent antibody technic.
Polymorphonuclear leukocyte motility in vitro. II. Stimulatory effect of monosodium urate crystals and urate in solution; partial inhibition by golchicine and indomethacin
Authors: Phelps Paulding 
Published: February 2007

AbstractStudies were performed to determine the effect of monosodium urate crystals on motility of polymorphonuclear leukocytes (PMN's) in vitro, using a modification of the Boyden chamber technic. A stimulatory effect on the random motility of PMN's (not chemotaxis) was demonstrated which could be explained entirely on the basis of the urate in solution and could be blocked by uricase, colchicine, and indomethacin.
External counting and scintiphotography in rabbits with arthritis
Authors: Sholkoff Stephen D. , Glickman Morton G. , Schachter Julius , Rowland Malcolm 
Published: February 2007

AbstractBedsonia arthritis in rabbits was studied by Anger camera Scintiphotography and external counting, using pertechnetate 99m as the label. This method of evaluating the intensity of the arthritis and the changes in the disease proved more sensitive and more accurate than did clinical and roentgenographic examinations.
Leukocyte‐connective tissue cell interaction. I. Stimulation of hyaluronate synthesis by live and dead leukocytes
Authors: Yaron Michael , Castor C. William 
Published: February 2007

AbstractDuring the interaction of fibroblasts and leukocytes in vitro, there was a two‐ to sixfold increase in the total amount of hyaluronate formed, and a corresponding increase in the rate (pg./cell/day) of hyaluronate synthesis. Increased glucose uptake from the culture medium (two‐ to fourfold) was associated with stimulation of hyaluronate formation. Cultures receiving leukocytes suffered an 8 to 33 per cent decrement in the fibroblast population. Leukocytes themselves consumed little glucose and produced no detectable hyaluronate. Viable and non‐viable lymphocytes and PMN's induced qualitatively similar behavioral alterations in synovial fibroblasts. Fibroblasts from normal and rheumatoid joints responded similarly to WBC. Normal and rheumatoid WBC had similar potential for altering the behavior of fibroblasts in vitro. Erythrocytes had little effect on fibroblast cultures.
The microvasculature of the synovial membrane of the monkey: Ultrastructural studies
Authors: Schumacher H. Ralph 
Published: February 2007

AbstractThe normal synovial microvasculature of Cebus albifrons monkeys is characterized by fenestrated superficial capillaries and venules, and deeper vessels with thicker, active‐appearing endothelium from which intravenously injected tracers occasionally were seen to have leaked. Carbon tracer was also identified in endothelial phagosomes. The possible roles of these vessels in joint inflammation is discussed. Leakage of still unidentified pathogenic agents from synovial vessels may be an early event in joint inflammation.
Osteoarthritis of the metacarpophalangeal joint: Hook‐like osteophytes
Authors: Swezey Robert L. , Peter J. B. , Evers Peter L. 
Published: February 2007

AbstractHook‐like osteophytic projections of the radial side of the distal head of the metacarpals are recorded in 7 per cent of 100 cases of Osteoarthritis. The development of such hooks is probably a response to articular cartilage degeneration and joint stress in the older age group. These hooks should not be confused with those of Jaccoud's disease.
Comparative bioassay of drugs in adjuvant‐induced arthritis in rats: Flufenamic acid, mefenamic acid, and phenylbutazone
Authors: Winder Claude V. , Lembke Lois A. , Stephens Marvin D. 
Published: February 2007

AbstractBy injecting adjuvant into the tail rather than paw, valid bioassays were achieved in terms of paw volume and body growth after preventive treatment for 18 days, treatment of the established disease for 6 weeks, and 6 weeks after termination of 6 weeks of therapy. By these six criteria, and with doses of the fenamates (per kilogram) equivalent to human dosage, flufenamate was 2.6 to 5.6 and mefenamate 0.35 to 1.8 times as potent as phenylbutazone.
Radioimmunoassay of rheumatoid factor
Authors: Franchimont P. , Suteanu S. 
Published: February 2007

AbstractA radioimmunological method for assaying rheumatoid factor is proposed and analyzed. The method is based on the reaction between rheumatoid factor, either purified or present in serum, and purified labeled yg globulin. This assay permits a quantitative estimation of rheumatoid factor levels in rheumatoid‐positive serum and provides evidence that rheumatoid‐negative serum contains factors which can bind labeled yg globulin. Normal serum assayed by this method does not ordinarily contain such factors.
Identification of collagen in synovial fluid
Authors: Kitridou Rodanthi , McCarty Daniel J. , Prockop Darwin J. , Hummeleh Klaus 
Published: February 2007

AbstractCollagen fibrils have been identified by electron microscopy and hydroxyproline assay in synovial fluid sediments from patients with a variety of joint diseases. Phase contrast and polarized light microscopy alone proved inadequate to distinguish these fibrils from fibrin strands. The potential sources and significance of the presence of collagen fibrils in synovial fluid sediments are discussed.
Immunological studies of an experimental chronic arthritis resembling rheumatoid arthritis
Authors: Astorga Gonzalo P. 
Published: February 2007

AbstractErysipelothrix insidiosa, injected intravenously into rabbits, produced a subacute generalized arthritis. The arthritic rabbits exhibited several serological manifestations considered characteristic of human rheumatoid arthritis. There was also hyperplasia of the synovial cells and hypertrophy of the villi, with infiltration by lymphocytes and plasma cells. It is concluded that this experimental condition may provide a model for the study of rheumatoid arthritis.
Human lymphocyte transformation induced by anti‐gamma globulin factors
Authors: King Richard A. , Messner Ronald P. , Williams Ralph C. 
Published: February 2007

AbstractHuman lymphocyte transformation was induced using cells from normal subjects and 19S human anti‐γ globulin preparations (rheumatoid factors). Considerable variation in the degree of lymphocyte stimulation using 19S human anti‐γ globulins and lymphocytes from normal donors was noted when identical experiments were repeated at 1 to 3 week intervals. When human 19S anti‐γ globulin factors were compared with 7S rabbit antibodies to human γ globulins, a much greater lymphocyte‐stimulating effect was noted with rabbit antisera. When an individual donor's lymphocytes were serially tested using rabbit antibody to human γG globulin as stimulating reagent, some correlation was noted between the amount of leukocyte‐associated γG and relative degrees of stimulation.
Characteristics of antinuclear factors in felty's syndrome
Authors: Brunner Carolyn M. , Davis Iv John S. , 
Published: February 2007

AbstractAntinuclear factors in the sera of 8 patients with Felty's syndrome were studied by various immunologic technics. All sera showed antinuclear factor activity. However, antinuclear factors in Felty's sera did not fix human complement, while antinuclear factors in 9 out of 10 control sera from patients with systemic lupus erythematosus did. This difference could be explained neither by a difference in antinuclear factor titer of the IgG class, nor by a blockage of complement fixation by rheumatoid factor. The findings of other investigators and the possible significance of antinuclear factor complement fixation are discussed.
Bone erosion in relation to subcutaneous rheumatoid nodules
Authors: Dorfman Howard D. , Norman Alex , Smith Richard J. 
Published: February 2007

AbstractTwo cases of bone erosion produced by subcutaneous rheumatoid nodules about the elbow are reported. The usual pattern of articular and para‐articular bone resorption is contrasted with the rare manifestation of bone‐scalloping by rheumatoid nodules. Rheumatoid nodules must be included in the differential diagnosis of cortical bone erosions.
Volar tenosynovitis of wrist in rheumatoid arthritis
Authors: Ranawat Chitranjan S. , Straub Lee Ramsay 
Published: February 2007

AbstractThe diagnosis of volar synovitis of the wrist in patients with rheumatoid arthritis is described. The patient may present with one or all of the following symptoms: (1) carpal tunnel syndrome, (2) pain and swelling over the volar aspect of the wrist and (3) progressive loss of active flexion of the fingers. Swelling is due to proliferative synovitis. It changes the normal contour of the wrist by accentuating the palmar slope and obliterating the forearm slope. Results of 60 volar tenosynovectomies performed on 52 patients with rheumatoid arthritis who were observed for an average follow‐up period of 3 1/2 years are described. Good and satisfactory results were obtained in 83% of the patients. The causes of failure are discussed. Early volar tenosynovectomy is indicated for patients who have progressive loss of active finger flexion due to volar tenosynovitis of the wrist.
Survivorship and Death in Rheumatoid Arthritis
Authors: Uddin Jamal , Kraus Fapha Arthur S. Scd , Garfield Kelly H. 
Published: February 2007

AbstractData are presented on survivorship and causes of death of 475 patients with rheumatioid arthritis, first seen betwen 1954 and 1966. The observed cumulative survival rate was lower than expected in each sex at each year of follow‐up, particularly in the later years. The adjusted rate was generally lower in males than in females. Eighteen of the 86 deaths due to known causes were attributed to infection, a significantly excessive proportion.
D‐Penicillamine in rheumatoid arthritis
Authors: Zuckner Jack , Ramsey Robert H. , Dorner Robert W. , Gantner Jr George E. 
Published: February 2007

AbstractD‐penicillamine was administered to 15 patients with rheumatoid arthritis. A fall in the titer of rheumatoid factor was demonstrated in all patients. The sedimentation rate decreased in most patients. There was no consistent alteration in immunoglobulins A, G or M or in lymphocyte transformation attributable to penicillamine. Ceruloplasmin serum levels were lowered significantly in 7 patients. Clinical improvement in the arthritis resulted in 10 patients.
Cardiac necrobiotic (Rheumatoid?) granulomas without arthritis. report of two cases
Authors: Good Armin E. , Lang Klaus , Olson John R. , Allen Frishette W. 
Published: February 2007

AbstractCardiac necrobiotic lesions resembling rheumatoid granulomas were discovered in 2 patients without evidence of arthritis. Evidence from the literature indicates that pulmonary and subcutaneous nodules may occur before arthritis or before the appearance of the rheumatoid factor, and that cardiac lesions may occur early in the course of rheumatoid disease. Even in the absence of obvious arthritis and the rheumatoid factor, rheumatoid disease should be considered part of the differential diagnosis of acquired valvular heart lesions.
Rheumatoid‐like nodules presenting as “pump bumps” in a patient without rheumatoid arthritis
Authors: Sturgill Benjamin C. , Hamilton Allan J. 
Published: February 2007

AbstractBilateral “pump bumps” removed from the heels of a 23‐year‐old woman had the histologic appearance of rheumatoid nodules. The patient had no symptoms, physical signs or laboratory evidence of rheumatoid arthritis.