bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRAIL predisposes non-small cell lung cancer to ferroptosis by regulating ASK-1/JNK1 pathway
Authors: Liu Xiaofang , Deng Huiqian , Huang Mi , Zhou Wei , Yang Yilin 
Published: February 2024

Abstract
Objective
Our current study aimed to assess the relationship between TNF-related apoptosis-inducing ligand (TRAIL) and ferroptosis in non-small cell lung cancer (NSCLC) development.

Methods
The expression of TRAIL was detected by western blot, RT-qRCR and immunohistochemistry. The viability of NSCLC cells was analyzed by CCK-8 kit. The migration and invasion of NSCLC cells were detected by wound healing assay and transwell assay, respectively. Labile iron pool (LIP) was detected based on the calcein-acetoxymethyl ester method. Ferrous iron (Fe2+) and iron levels were assessed by detection kits. The levels of superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) were measured using corresponding detection kits. Mice tumor xenograft models were used for the in vivo research.

Results
The expression of TRAIL was reduced in H1299, NCL-H1395, and A549 cells compared with BEAS-2B cells. The up-regulation of TRAIL expression significantly reduced cell viability, invasion, and migration of H1299 and A549 cells. TRAIL reduced the expression of ferroptosis-related genes (FTH1, GPX4, and SLC7A11), increased the levels of LIP, iron, and Fe2+, and promoted lipid peroxidation, thereby predisposing NSCLC cells to ferroptosis. TRAIL up-regulated the expression of phosphate modification of ASK-1 and JNK. ASKI-1 inhibitor GS-4977 attenuated the effects of TRAIL on the viability, migration, invasion, and ferroptosis of H1299 cells. Furthermore, TRAIL further suppressed tumor growth and ferroptosis in mice tumor xenograft models.

Conclusion
We indicated that overexpression of TRAIL induced ferroptosis in NSCLC cells and exerted anti-tumor effects. Mechanistically, TRAIL promoted ferroptosis by the activation of the ASK-1/JNK1 pathway. Our results may provide new therapeutic strategies for NSCLC.
Vertical dynamic measurements of a railway transition zone: a case study in Sweden
Authors: Unsiwilai Siwarak , Shen Chen , Zeng Yuanchen , Wang Li , Núñez Alfredo , Li Zili 
Published: February 2024

AbstractThis study presents a measuring framework for railway transition zones using a case study on the Swedish line between Boden and Murjek. The final goal is to better understand the vertical dynamics of transition zones using hammer tests, falling weight measurements, and axle box acceleration (ABA) measurements. Frequency response functions (FRFs) from hammer tests indicate two track resonances, for which the FRF magnitudes on the plain track are at least 30% lower than those at the abutment. The falling weight measurements indicate that the track on the bridge has a much higher deflection than the track on the embankment. Two features from ABA signals, the dominant spatial frequency and the scale average wavelet power, show variation along the transition zone. These variations indicate differences in track conditions per location. Finally, the ABA features in the range of 1.05–2.86 m−1 are found to be related to the track resonance in the range of 30–60 Hz. The findings in this paper provide additional support for physically interpreting train-borne measurements for monitoring transition zones.
Rough Volatility: Fact or Artefact?
Authors: Cont Rama , Das Purba 
Published: February 2024

AbstractWe investigate the statistical evidence for the use of ‘rough’ fractional processes with Hurst exponent $$H< 0.5$$

H
<
0.5

for modeling the volatility of financial assets, using a model-free approach. We introduce a non-parametric method for estimating the roughness of a function based on discrete sample, using the concept of normalized p-th variation along a sequence of partitions. Detailed numerical experiments based on sample paths of fractional Brownian motion and other fractional processes reveal good finite sample performance of our estimator for measuring the roughness of sample paths of stochastic processes. We then apply this method to estimate the roughness of realized volatility signals based on high-frequency observations. Detailed numerical experiments based on stochastic volatility models show that, even when the instantaneous volatility has diffusive dynamics with the same roughness as Brownian motion, the realized volatility exhibits rough behaviour corresponding to a Hurst exponent significantly smaller than 0.5. Comparison of roughness estimates for realized and instantaneous volatility in fractional volatility models with different values of Hurst exponent shows that, irrespective of the roughness of the spot volatility process, realized volatility always exhibits ‘rough’ behaviour with an apparent Hurst index $$\widehat{H}<0.5$$

H
^

<
0.5

. These results suggest that the origin of the roughness observed in realized volatility time series lies in the estimation error rather than the volatility process itself.
Lateral Thinking: The Lateral Arm Approach for Stereotactic-Guided Breast Biopsies. What We’ve Learned So Far
Authors: Najmi Nooshin , Rashid Mollie A. , Fardanesh Reza , Fischer Cheryce P. 
Published: February 2024

Abstract
Purpose of Review
The purpose of this paper is to review a novel technique for stereotactic-guided breast biopsies utilizing the lateral arm approach.

Recent Findings
Successful stereotactic-guided biopsies require careful consideration of lesion location and patient anatomy. Cases that cannot be safely performed are often referred for surgical biopsy, which can increase patient anxiety and delay diagnosis. The lateral arm approach provides an alternative needle approach for biopsy that can mitigate some of the most common exclusion criteria for standard techniques. Although there are many benefits to the lateral arm approach, it has not yet been widely adopted. This article reviews the lateral arm approach, including patient selection, procedural technique, advantages, and disadvantages. Case examples utilizing the technique will also be discussed to illustrate our institutional experience (including procedural tips) and how the lateral arm approach can be integrated into breast imaging practice.

Summary
The lateral arm approach can expand the patient population that can undergo stereotactic-guided breast biopsy, which may obviate the need for surgical biopsy or short-term follow-up. The technique also allows for a creative approach to biopsy in challenging cases. Proficiency with the lateral arm approach can expand a breast imager’s interventional skills, improve patient care, and allow for more expedient diagnosis of suspicious breast findings.
Process comparison of laser deep penetration welding in pure nickel using blue and infrared wavelengths
Authors: Möbus M. , Pordzik R. , Krämer A. , Mattulat T. 
Published: February 2024

AbstractLaser sources with wavelengths in the visible blue spectrum are suitable for heat conduction mode welding of materials like copper and nickel due to the significantly increased Fresnel absorption compared to infrared laser radiation. Recently, blue laser sources with 445 nm wavelength have become available with sufficient power and beam parameters to exceed the intensity threshold for laser deep penetration welding. In laser beam deep penetration welding, the total absorption is significantly increased due to the multiple reflections in the keyhole compared to heat conduction mode welding. However, since the absorbed energy per reflection inside the keyhole is wavelength-dependent, it can be hypothesized that the choice of laser wavelength causes changes in the local energy distribution inside the keyhole, changing the keyhole dynamics. To investigate this, laser beam deep penetration welding experiments were carried out on 2.4068 pure nickel using an infrared laser source and a blue laser source with comparable beam properties. The experiments were monitored and compared by a multi-sensor setup and metallographic analyses. This setup included measurements of airborne acoustic emissions and two high-speed video cameras for spatter tracking and tracking of the keyhole area. The use of a blue laser beam led to a lower spatter quantity, an increase of porosity and a significant change of acoustic emissions, proving the hypothesis for pure nickel.
The relationship between trajectories of renal oxygen saturation and acute kidney injury: a prospective cohort study with a secondary analysis
Authors: Liu Chang , Wang Xiaoxiao , Shi Wenzhu , Yu Yao , Sha Xiaoling , Wang Peipei , Yao Siyi , Li Zhao , Liu Yanhong , Cao Jiangbei , Li Hao , Mi Weidong 
Published: February 2024

Abstract
Background
Acute kidney injury (AKI) is a major postoperative consequence, affecting prognosis of older patients. Effective prediction or intervention to predict or prevent the incidence of AKI is currently unavailable.

Aims
Dynamic changes of renal tissue oxygen saturation (RSO2) during surgery process are understudied and we intended to explore the distinct trajectories and associations with postoperative AKI.

Methods
This was a secondary analysis including data for older patients who underwent open hepatectomy surgery with informed consent. Latent class mixed models (LCMM) method was conducted to generate trajectories of intraoperative renal tissue RSO2 through different time points. The primary outcome was postoperative 7-day AKI. The univariate and multivariate regression analysis were performed to identify the relationship between distinct trajectories of renal tissue RSO2 and the risk of AKI. Meanwhile, the prediction efficacy of renal tissue RSO2 at different time points was compared to find potential intervention timing.

Results
Postoperative AKI occurred in 14 (15.2%) of 92 patients. There are two distinct renal tissue RSO2 trajectories, with 44.6% generating "high-downwards" trajectory and 55.4% generating "consistently-high" trajectory. Patients with "high-downwards" trajectory had significantly higher risk of postoperative AKI than another group (Unadjusted OR [Odds Ratio] = 3.790, 95% CI [Confidence Interval]: 1.091–13.164, p = 0.036; Adjusted OR = 3.973, 95% CI 1.020–15.478, p = 0.047, respectively). Predictive performance was 71.4% sensitivity and 60.3% specificity for "high-downwards" trajectory of renal tissue RSO2 to identify AKI. Furthermore, the renal tissue RSO2 exhibited the lowest level and the best results in terms of the sensitivity during the hepatic occlusion period, may be considered as a "time of concern".

Conclusions
Older patients undergoing hepatectomy may show high-downwards trajectory of renal tissue RSO2, indicating a higher risk of AKI, and the lowest level was identified during the hepatic occlusion period. These findings may help to provide potential candidates for future early recognition of deterioration of kidney function and guide interventions.
PDOL-Based Solid Electrolyte Toward Practical Application: Opportunities and Challenges
Authors: Yang Hua , Jing Maoxiang , Wang Li , Xu Hong , Yan Xiaohong , He Xiangming 
Published: February 2024

Abstract
Polymer solid-state lithium batteries (SSLB) are regarded as a promising energy storage technology to meet growing demand due to their high energy density and safety. Ion conductivity, interface stability and battery assembly process are still the main challenges to hurdle the commercialization of SSLB. As the main component of SSLB, poly(1,3-dioxolane) (PDOL)-based solid polymer electrolytes polymerized in-situ are becoming a promising candidate solid electrolyte, for their high ion conductivity at room temperature, good battery electrochemical performances, and simple assembly process. This review analyzes opportunities and challenges of PDOL electrolytes toward practical application for polymer SSLB. The focuses include exploring the polymerization mechanism of DOL, the performance of PDOL composite electrolytes, and the application of PDOL. Furthermore, we provide a perspective on future research directions that need to be emphasized for commercialization of PDOL-based electrolytes in SSLB. The exploration of these schemes facilitates a comprehensive and profound understanding of PDOL-based polymer electrolyte and provides new research ideas to boost them toward practical application in solid-state batteries.
Optimal HDR exploitation siting of gravity heat pipe geothermal systems via reservoir simulation
Authors: Zhou Chunwei , Wang Yaqiong , Liu Gang , Liao Shengming 
Published: February 2024

AbstractGravity heat pipe system has previously been proven as an environmental and efficient technology in exploiting hot dry rock. However, it is unclear what geothermal reservoir siting is more favorable for the system’s heat extraction performance. Herein, we analyzed the influences of geothermal field siting (rock property and reservoir environment) on heat extraction performance of gravity heat pipe systems through a 3D thermal–hydraulic coupled model. It is found that rock properties have huge influences on heat compensation, heat extraction ratio and heat compensation ratio. Low rock density, low rock specific heat capacity and high thermal conductivity could increase heat compensation, heat extraction ratio and heat compensation ratio. It is also found that geothermal reservoir environment affects the heat extraction rate seriously. High initial temperatures and low temperature gradients increase heat extraction rates. Geothermal reservoir pressure affects the heat extraction performance slightly, and low initial pressures increase heat extraction rate. The study results would provide suggestions on deep geothermal exploitation locations.
Complex network effects on the robustness of graph convolutional networks
Authors: Miller Benjamin A. , Chan Kevin , Eliassi-Rad Tina 
Published: February 2024

AbstractVertex classification using graph convolutional networks is susceptible to targeted poisoning attacks, in which both graph structure and node attributes can be changed in an attempt to misclassify a target node. This vulnerability decreases users' confidence in the learning method and can prevent adoption in high-stakes contexts. Defenses have been proposed, focused on filtering edges before creating the model or aggregating information from neighbors more robustly. This paper considers an alternative: we investigate the ability to exploit network phenomena in the training data selection process to improve classifier robustness. We propose two alternative methods of selecting training data: (1) to select the highest-degree nodes and (2) to select nodes with many connections to the test data. In four real datasets, we show that changing the training set often results in far more perturbations required for a successful attack on the graph structure; often a factor of 2 over the random training baseline. We also run a simulation study in which we demonstrate conditions under which the proposed methods outperform random selection, finding that they improve performance most when homophily is higher, clustering coefficient is higher, node degrees are more homogeneous, and attributes are less informative. In addition, we show that the methods are effective when applied to adaptive attacks, alleviating concerns about generalizability.
Discretionary policing: following religious beliefs or operational guidelines, decision-making, and citizen engagement
Authors: Miles-Johnson Toby 
Published: February 2024

AbstractIn an Australian context, there is little research which examines whether officers following a religion will place religious ideologies beyond professional guidelines and whether there are differences between religious and non-religious officers regarding decision-making and use of discretion. This raises questions about how religious and non-religious officers will engage with citizens whose identities may be similar to, or different from the responding officer, and, whether the citizen’s identity challenges an officer’s religious ideologies; thereby shaping police-citizen interaction. Whether religious or non-religious police officers are more likely to police equitably is an area of research that needs systematic enquiry; especially given that officers who are religious could apply discretional policing when adhering to religious beliefs or practices during decision-making, and, conversely, officers who are non-religious, could apply discretional adherence to organizational rules, regulations, and police training. As such, this preliminary, exploratory study sought to address this gap in knowledge. Analyzing data collected from a sample of officers (N = 1425) working in one Australian police organization, this study provides insight into how religious or non-religious beliefs shapes officers’ discretional decision-making, and citizen engagement.
Modified genetic algorithm to solve worker assignment problem with time windows
Authors: Gozali Alfian Akbar 
Published: February 2024

AbstractIn recent years, the demand for electronic products has been increasing rapidly. T mounting technology (SMT) line is one of the production areas for electronic products, directly affecting this situation. In an SMT line, multiple machines mount electronic parts to the board. The worker must complete work when the parts used in these machines are within the remaining parts available for replacement. When a worker fails to replace parts at the right time, the production line stops, and delays occur. Besides, there may be a designated worker who should be assigned to each task. In the current situation, workers’ work procedures are not optimized, so they should schedule work procedures for each worker. This problem is called Worker Assignment Problem with Time Window (WAPTW). This paper proposes a method to solve WAPTW called Genetic Algorithm with Local Restriction (GALR). GALR combines a genetic algorithm (GA) and local search with local restriction. This paper’s main contribution is introducing WAPTW as a novel real-world optimization problem in an electricity company, its mathematical formulation, and a proposed GALR to solve WAPTW. The experiment shows that the proposed method could yield the best result in real-world WAPTW compared with other methods.
The Anarchist and the Technocrat: Herbert Read, C. P. Snow, and the Future of Britain
Authors: Adams Matthew S. 
Published: February 2024

AbstractA conceptual revision occurred at the heart of anarchist theory between the end of the nineteenth and the mid-twentieth centuries. As anarchist thinkers grappled with a state transformed beyond recognition by technological change, they reassessed their critique of state power and the rhetorical methods used to expose its inherent violence. Where nineteenth-century anarchists favored organic metaphors to emphasize the monstrosity of the state, twentieth-century anarchists tended to adopt a set of mechanical metaphors. This change focused attention on the idea of technocracy, and informed a more comprehensive assessment of the state's activities. This article analyses this innovation in anarchist political thought, before tracing it through to Herbert Read's critical appraisal of C. P. Snow's influential lecture “The Two Cultures and the Scientific Revolution,” and Snow's response to Read. Their debate, in which Read challenged Snow's argument that the pursuit of technological and political modernization was essential to maintain the nation's international role and address the social and economic challenges of the mid-century, was a contest for Britain's future. Drawing on his anarchism, Read saw such ideas as an existential threat, with the unthinking promotion of a technological “revolution” imperiling “the tender shoots of all that is human.” Contextualizing Read in his anarchist intellectual milieu, this article recovers a neglected voice in British intellectual and cultural history, the complexities of an overlooked political tradition, and a radical vision of Britain's future that questioned the dominant assumptions of the age.
Linking enterprise information systems success to female employees’ work–family enrichment in China
Authors: Deng Wenhao , Yang Tianan , Ju Xuemei , Deng Jianwei 
Published: February 2024

Abstract
The spread and application of enterprise information systems (EISs) has provided scholars and managers with a new perspective to enhance the work–family enrichment. Based on the work–family enrichment theory, this research aims to examine the ability of female employees to enhance their work–family enrichment by applying the resources accumulated through the use of EISs by combining the technology acceptance model with the DeLone & McLean Information Systems Success Model. The findings based on a survey of 823 full-time female employees in China indicated that the information systems quality factors (including information quality, system quality, and service quality) were positively associated with female employees’ work–family enrichment. In addition, the chained mediating effect of perceived ease of use and perceived usefulness was examined. The results can help female employees to perform positively in both work and family spheres and provide positive support for the promotion of the social fertility policies.
Deictic shift in the production of direct and indirect speech
Authors: Li Jianan , Dijkstra Katinka , Zwaan Rolf A. 
Published: February 2024

Abstract
We investigated how deictic shifts and memory representation influence production difficulties in reported speech. In Experiment 1, participants read short stories, including a conversation between two protagonists. Participants then recalled the last sentence from the conversation in either direct or indirect speech. When participants had verbatim memory of the to-be-reported utterance, direct speech production was faster than indirect speech if indirect speech production required a deictic shift. If participants had verbatim memory and indirect speech production did not require a deictic shift, direct and indirect speech’s speech latencies were similar. In Experiment 2, we investigated the production difficulties of reported speech when verbatim memory was unavailable to participants. First, participants read short stories. Next, half of the participants completed an intervening task, whereas the other half did not. Last, participants undertook a sentence completion task by filling in a missing word in direct or indirect speech. When participants did not have verbatim memory of to-be-reported utterances, direct speech production was faster than indirect speech if a deictic shift was needed to produce direct speech. These results suggest that production difficulties in reported speech depend on how to-be-reported utterances are represented in memory and whether deictic shifts are required.
Transverse magnetic field effects on the high-voltage pulsed discharge plasma in helium
Authors: Chen C. , Rabadanov K. M. , Ashurbekov N. A. , Yuan C. , Shakhrudinov A. M. 
Published: February 2024

This study investigates the effect of a transverse magnetic field on high-voltage pulsed discharge in helium at a pressure of 30 Torr. A simple two-dimensional fluid model that describes the high-voltage pulsed discharge in helium in a transverse weak magnetic field (B = 0.4 T) is presented, which uses an empirical relation to account for the magnetic field. The results of using the empirical relation for the effective field agree well with the experimental results. The dynamics of discharge development in the presence of the magnetic field is also investigated. The magnetic field does not significantly affect the gas-discharge development dynamics in helium at a pressure of 30 Torr.