bluuebunny/crossref_metadata_2025_split huggingface dataset:
Communication of individuals with CDKL5 deficiency disorder as observed by caregivers: A descriptive qualitative study
Authors: Keeley Jessica , Benson‐Goldberg Sofia , Saldaris Jacinta , Lariviere Judy , Leonard Helen , Marsh Eric D. , Demarest Scott T. , Benke Tim A. , Jacoby Peter , Downs Jenny 
Published: March 2024

AbstractCDKL5 deficiency disorder (CDD) is a genetically caused developmental epileptic encephalopathy that causes severe communication impairments. Communication of individuals with CDD is not well understood in the literature and currently available measures are not well validated in this population. Accurate and sensitive measurement of the communication of individuals with CDD is important for understanding this condition, clinical practice, and upcoming interventional trials. The aim of this descriptive qualitative study was to understand how individuals with CDD communicate, as observed by caregivers. Participants were identified through the International CDKL5 Disorder Database and invited to take part if their child had a pathogenic variant of the CDKL5 gene and they had previously completed the Communication and Symbolic Behavior Checklist (CSBS‐DP ITC). The sample comprised caregivers of 23 individuals with CDD, whose ages ranged from 2 to 30 years (median 13 years), 15 were female, and most did not use words. Semistructured interviews were conducted via videoconference and analyzed using a conventional content analysis. Three overarching categories were identified: mode, purpose and meaning, and reciprocal exchanges. These categories described the purposes and mechanism of how some individuals with CDD communicate, including underpinning influential factors. Novel categories included expressing a range of emotions, and reciprocal exchanges (two‐way interactions that varied in complexity). Caregivers observed many communication modes for multiple purposes. Understanding how individuals with CDD communicate improves understanding of the condition and will guide research to develop accurate measurement for clinical practice and upcoming medication trials.
Electrostatic Field in Contact‐Electro‐Catalysis Driven C−F Bond Cleavage of Perfluoroalkyl Substances
Authors: Wang Yanfeng , Zhang Jing , Zhang Wenkai , Yao Jiaming , Liu Jinyong , He Huan , Gu Cheng , Gao Guandao , Jin Xin 
Published: March 2024

AbstractPerfluoroalkyl substances (PFASs) are persistent and toxic to human health. It is demanding for high‐efficient and green technologies to remove PFASs from water. In this study, a novel PFAS treatment technology was developed, utilizing polytetrafluoroethylene (PTFE) particles (1–5 μm) as the catalyst and a low frequency ultrasound (US, 40 kHz, 0.3 W/cm2) for activation. Remarkably, this system can induce near‐complete defluorination for different structured PFASs. The underlying mechanism relies on contact electrification between PTFE and water, which induces cumulative electrons on PTFE surface, and creates a high surface voltage (tens of volts). Such high surface voltage can generate abundant reactive oxygen species (ROS, i.e., O2⋅−, HO⋅, etc.) and a strong interfacial electrostatic field (IEF of 109~1010 V/m). Consequently, the strong IEF significantly activates PFAS molecules and reduces the energy barrier of O2⋅− nucleophilic reaction. Simultaneously, the co‐existence of surface electrons (PTFE*(e−)) and HO⋅ enables synergetic reduction and oxidation of PFAS and its intermediates, leading to enhanced and thorough defluorination. The US/PTFE method shows compelling advantages of low energy consumption, zero chemical input, and few harmful intermediates. It offers a new and promising solution for effectively treating the PFAS‐contaminated drinking water.
A rapid assessment method to monitor the health status of habitat‐forming species in coastal benthic ecosystems
Authors: Figuerola‐Ferrando Laura , Garrabou Joaquim , Linares Cristina 
Published: March 2024

Abstract
Marine habitat‐forming (MHF) species in the Mediterranean are among the most threatened coastal species by human activities. In recent decades, different stressors (e.g., warming‐induced marine heatwaves and algal blooms) have caused mass mortality events in these key species. Overall, a common method to assess their health status at the Mediterranean Sea scale is lacking.
To fill this gap, the aim of this work is to present and validate a cost‐effective method, the Mortality Rapid Assessment Method, that is able to assess the health status of key MHF species, even through Citizen Science.
The Mortality Rapid Assessment Method is based on determining the impact of mortality on MHF species derived from the metric percentage of affected colonies or individuals. To validate the ability of the proposed method to assess the health status, it was compared to a more commonly used but time‐consuming and expert‐required metric based on the injured surface percentage of the colonies or individuals. For the validation, one of the most extensive (>47,500 colonies) demographic datasets of the octocoral Paramuricea clavata was used to conduct a comprehensive metric comparison.
The results showed a highly significant correlation between metrics from both methods (ρ = 0.86), confirming that the percentage of affected colonies provides a reliable assessment of the health status of gorgonian populations over broad spatial and temporal scales.
Bearing in mind that this metric can be applied to different MHF species, such as sponges, bryozoans and calcareous algae, and by non‐scientific personnel (managers and trained volunteers), its implementation can contribute to inform and enhance the effectiveness of the conservation and management plans for key MHF species at the scale of the Mediterranean Sea.
Spectroscopic and photometric behavior of LP Ori
Authors: Elmaslı Aslı , Ünal Kübra Özge , Özuyar Doğus 
Published: March 2024

AbstractWe performed spectroscopic and photometric analyses on the early B‐type LP Ori young stellar object located in the Orion Nebula. The high‐resolution spectra of LP Ori was obtained at the Ankara University Kreiken Observatory in 2023, while all spectra recorded over the past 19 years were extracted from the ESO and ESPaDOnS archives. In these spectra of LP Ori, there is typically an emission observed in the core of the Balmer profile. This structure is accompanied by a 14‐year interval inverse P‐Cygni repetition superimposed on the Balmer profile. Additionally, an emission in the 5,875 He I line is visible in the spectra in the year 2023. When this emission is considered together with the inverse P‐Cygni structures, these observations suggest that LP Ori is a Herbig Ae/Be star. The abundance pattern of LP Ori is close to solar with the exception of a slightly rich helium and slightly poor aluminum abundance. Additionally, the spectral energy distribution of LP Ori was constructed to confirm the infrared excess caused by its circumstellar disk. Furthermore, the photometric analysis performed on the TESS observations of LP Ori shows significant photometric variability and the frequency analysis reveals a Cephei star in its forthcoming evolution.
Hydrogels for ameliorating osteoarthritis: Mechanical modulation, anti‐inflammation, and regeneration
Authors: Jiang Xuwei , Sun Yuxiang , Lyu Yuanning , Kang Heemin , Zhao Jianyang , Zhang Kunyu , Bian Liming 
Published: March 2024

AbstractOsteoarthritis (OA) is a chronic and degenerative disease with limited clinical options for effective suppression. Recently, significant endeavors have been explored to reveal its pathogenesis and develop treatments against OA. Hydrogels, designed with a striking resemblance to the extracellular matrix, offer a biomimetic interaction with biological tissues, presenting a promising avenue for OA amelioration. As a result, biocompatible hydrogels have been erected incorporating on‐demand bioactivities to optimize the intra‐articular microenvironment, thereby alleviating OA symptoms and fostering the eventual regeneration of articular joints. This review highlights the collaborative objectives underlying the establishment of this tissue microenvironment, encompassing mechanical modulation, anti‐inflammation, and tissue regeneration. Specifically, we consolidate recent advances in hydrogel‐based biomaterials, serving as the tissue engineering scaffolds to replicate the lubrication properties of natural joints or the bioactive agent‐loaded vehicles to combat localized inflammation. Additionally, hydrogels function as cell scaffolds to facilitate the maintenance of cellular homeostasis and contribute to the advancement of cartilage regeneration. Finally, this review outlines the prospective directions for hydrogel‐mediated OA therapies.
Borago Officinalis L.: A Review Oon Extraction, Phytochemical, and Pharmacological Activities
Authors: Slama Meriem , Slougui Nabila , Benaissa Akila , Nekkaa Amine , Sellam Feriel , Canabady‐Rochelle Laetitia 
Published: March 2024

AbstractBorago officinalis L., an annual herb belonging to the Boraginaceae family, is used in the traditional medical practices of various countries and for multiple treatments, including respiratory disorders, colds, influenza, diarrhea, cramps, inflammation, palpitation, hypertension menopause, and post‐menopausal symptoms. Its pharmacological properties and biological activities ‐ among them antioxidant, antimicrobial, anticancer, anti‐inflammatory, insecticidal, antigenotoxic, and anti‐obesity activity ‐ were demonstrated in vitro and in vivo and are related to its rich content of bioactive compounds (mainly phenolic acids, flavonoids, anthocyanins, alkaloids, and terpenes) extracted from various parts of B. officinalis including leaves, flowers, seeds, and roots. This review summarizes all updated information on applied extraction processes, phytochemistry, pharmacology, and toxicity of B. officinalis.
Discovery of Novel Hybrids of Edaravone and 6‐Phenyl‐4,5‐dihydropyridazin‐3(2H)‐one with Antiplatelet Aggregation and Neuroprotection for Ischemic Stroke Treatment
Authors: Li Yi , He Jieying , Luo Bilan , Yu Qinyang , Cai Ting , Li Yong , Fan Lingling , Zhou Xunrong , Tang Lei 
Published: March 2024

AbstractDrugs with anti‐platelet aggregation and neuroprotection are of great significance for the treatment of ischemic stroke. A series of edaravone and 6‐phenyl‐4,5‐dihydropyridazin‐3(2H)‐one hybrids were designed and synthesized. Among them, 6g showed the most effective cytoprotective effect against oxygen‐glucose deprivation/reoxygenation‐induced damage in BV2 cells and an excellent inhibitory effect on platelet aggregation induced by adenosine diphosphate and arachidonic acid. Additionally, 6g could prevent thrombosis caused by ferric chloride in rats and pose a lower risk of causing bleeding compared with aspirin. It provides better protection against ischemia/reperfusion injury in rats compared with edaravone and alleviates the oxidative stress related to cerebral ischemia/reperfusion by increasing the GSH and SOD levels and decreasing the MDA concentration. Finally, molecular docking results showed that 6g probably acts on PDE3 A and plays an anti‐platelet aggregation effect. Overall, 6g could be a potential candidate compound for the treatment of ischemic stroke.
Synthesis and Antimicrobial Activity Evaluation of Pyridine Derivatives Containing Imidazo[2,1‐b][1,3,4]Thiadiazole Moiety
Authors: Yang Liu , Jiao Yu‐Xin , Quan Yan‐Hua , Li Ming‐Yu , Huang Xin‐Yi , Jin Jun‐Zheng , Li Siqi , Quan Ji‐Shan , Jin Cheng‐Hua 
Published: March 2024

AbstractFour series of novel pyridine derivatives (17 a–i, 18 a–i, 19 a–e, and 20 a–e) were synthesized and their antimicrobial activities were evaluated. Of all the target compounds, almost half target compounds showed moderate or high antibacterial activity. The 4‐F substituted compound 17 d (MIC=0.5 μg/mL) showed the highest antibacterial activity, its activity was twice the positive control compound gatifloxacin (MIC=1.0 μg/mL). For fungus ATCC 9763, the activities of compounds 17 a and 17 d are equivalent to the positive control compound fluconazole (MIC=8 μg/mL). Furthermore, compounds 17 a and 17 d showed little cytotoxicity to human LO2 cells, and did not show hemolysis even at ultra‐high concentration (200 μM). The results indicate that these compounds are valuable for further development as antibacterial and antifungal agents.
Maxillary root amputation: Case report with a 14‐year‐follow‐up and updated mini review
Authors: Ajlan Sumaiah A. 
Published: March 2024

Key Clinical MessageRoot resection is performed to create a maintainable furcation area in teeth with advanced periodontitis. However, the long‐term feasibility of this treatment remains controversial. We present a case in which distal root resection in a maxillary molar successfully preserved the form and function of the dentition for approximately 14 years.
Intramolecular Phenyl Transfer from a Boronate to Lithium in the Gas Phase Reveals Crucial Role of Solvation in Transmetalations
Authors: Kraft Finn , Koszinowski Konrad 
Published: March 2024

AbstractIn contrast to its behavior in solution, the adduct [(LiBr)(tBu)(Ph)Bpin]− (pin=pinacol) transfers its phenyl anion from boron to lithium upon fragmentation in the gas phase. Quantum chemical calculations predict this exceptional transmetalation to be exothermic relative to the separated reactants, [(tBu)(Ph)Bpin]− and LiBr, which we attribute to the high phenyl‐anion affinity of the coordinatively unsaturated LiBr unit. The addition of a single molecule of tetrahydrofuran drastically reduces the phenyl‐anion affinity of LiBr and thereby renders the transmetalation from boron to lithium endothermic. Thus, the probed system highlights the importance of solvation and ligation effects in transmetalations. For correctly predicting the direction, in which these reactions proceed, it is not sufficient to consider the electronegativities or partial charges of the involved metals or metalloids. Instead, the individual coordination states and their changes over the course of the reaction must be taken into account.
Non‐pharmacological interventions for asthma prevention and management across the life course: Umbrella review
Authors: Tong Xunliang , Zhang Xinyue , Wang Mengyuan , Wang Zijun , Dong Fawu , Gong Enying , Zuberbier Torsten , Li Yanming 
Published: March 2024

AbstractBackgroundThe impact of non‐pharmacological interventions (NPIs) on asthma prevention and management is insufficiently examined. We aim to comprehensively evaluate and synthesize existing evidence regarding the effectiveness of various NPIs throughout the life course.MethodsWe conducted a systematic search and screening of reviews that examined the effectiveness of various NPIs on asthma prevention and control in the Cochrane Library, PubMed, Embase, and Ovid databases. Data extraction was performed by considering the type of NPIs and the life course stages of the target population. Recommendations were provided by considering the quality of review assessed using the AMSTAR2 tool and the consistency of findings across reviews.ResultsWe identified 145 reviews and mapped the evidence on the impact of 25 subtypes of NPIs on asthma prevention and control based on five stages of life course. Reviews indicated a shift of focus and various impacts of major NPIs on asthma prevention and control across life courses, while a few types of NPIs, such as physical exercise, appeared to be beneficial in children, adolescents and adults. Consistent and high‐level evidence was observed only for psychological intervention on asthma control and quality of life among adults and older adults. Potential benefit with high‐level evidence was reported on certain NPIs, such as vitamin D in reducing risk of developing asthma in offsprings in the prenatal stage, digital health interventions in improving asthma control from childhood to older adulthood, and breathing exercise in improving quality of life, asthma‐related symptoms and lung function in adulthood and older adulthood.ConclusionThis study emphasizes the significance of delivering NPIs to improve asthma prevention and management and highlights the heterogeneity regarding the impact of NPIs across life courses. High‐quality research is urgently needed to further strengthen the evidence base of NPIs and tailored interventions should be considered in guideline development.
Development and verification of a novel immunogenic cell death‐related signature for predicting the prognosis and immune infiltration in triple‐negative breast cancer
Authors: Li Jiachen , Li Zhengtian , Yang Wenkang , Pan Jianmin , You Huazong , Yang Lixiang , Zhang Xiaodong 
Published: March 2024

AbstractBackgroundInsufficient understanding of the pathogenesis and tumor immunology of triple‐negative breast cancer (TNBC) has limited the development of immunotherapy. The importance of tumor microenvironment (TME) in immunotyping, prognostic assessment and immunotherapy efficacy of cancer has been emphasized, however, potential immunogenic cell death (ICD) related genes function in TME of TNBC has been rarely investigated.AimsTo initially explore the role and related mechanisms of ICD in TNBC, especially the role played in the TME of TNBC, and to identify different relevant subtypes based on ICD, and then develop an ICD‐related risk score to predict each TNBC patient TME status, prognosis and immunotherapy response.Methods and resultsIn this study, we identified distinct ICD‐related modification patterns based on 158 TNBC cases in the TCGA‐TNBC cohort. We then investigated the possible correlation between ICD‐related modification patterns and TME cell infiltration characteristics in TNBC. By using univariate Cox and least absolute shrinkage and selection operator (LASSO) regression analysis, we created a risk scoring system (ICD score) to quantifiably evaluate the impact of ICD‐related modification patterns in individual TNBC patient. Two different ICD‐related modification patterns were found with significant differences in immune infiltration. Lower ICD score was correlated with higher immune infiltration, tumor mutational burden and significantly enriched in immune‐related pathways, indicating a strong ability to activate immune response, which might account for relatively favorable prognosis of TNBC patients and could serve as a predictor to select suitable candidates for immunotherapy. We used two independent cohorts, GSE58812 cohort and Metabric cohort to validate prognosis and immunohistochemistry for preliminary in vitro validation.ConclusionThis study evidenced that the ICD‐related modification patterns might exert pivotal roles in the immune infiltration landscape of TNBC and ICD score might act as potential predictors of prognostic assessment and immunotherapy response. This research provides unique insights for individualize immune treatment strategies and promising immunotherapy candidates screening.
FPHO: Fractional Pelican Hawks optimization based container consolidation in CaaS cloud
Authors: Patra Manoj Kumar , Sahoo Bibhudatta , Turuk Ashok Kumar 
Published: March 2024

AbstractContainers in cloud computing provide a logical packaging technique for applications to be isolated from the computing environment in which they actually execute, allowing for efficient sharing of memory, processor, storage, and network resources at the Operating System (OS) level. Since they are so compact, container‐based clouds have recently gained significant popularity. In order to maximize resource usage and minimize energy consumption, the container consolidation technique is widely employed in the cloud environment. This work introduces container consolidation in cloud computing that exploits Fractional Pelican Hawks Optimization (FPHO). In Container as a Service (CaaS) model, containers are placed in the Virtual Machines (VMs), and virtual machines are hosted in Physical Machines (PMs) or servers. The proposed method for container consolidation consists of two modules, namely, the host status module and the consolidation module. In the host status module, the PM's load is predicted using Long Short Term Memory (LSTM) and checked whether the PM is overloaded or underloaded using a threshold. If it is overloaded, the container selection algorithm is performed, and the migration list is also generated. In the consolidation module, the created migration list which is employed for the destination list to be created by an overloaded destination selector. In the same way, the underloaded list is also generated by the underloaded destination selector. Finally, the container and VM migration is carried out by considering the multi‐objectives such as predicted load, migration cost, resource utilization, energy consumption, network, and bandwidth which are optimally selected by the proposed FHPO. Here, FHPO is the combination of Fractional Pelican Optimization (FPO) and Fire Hawk Optimizer (FHO). The designed model achieved the measures with minimum energy consumption, resource utilization, Service Level Agreement (SLA), and Makespan as 0.066, 0.019, 0.054, and 0.066, respectively for setup one.
Prediction of Feasibility of Polaronic OER on (110) Surface of Rutile TiO2
Authors: Pada Sarker Hori , Abild‐Pedersen Frank , Bajdich Michal 
Published: March 2024

AbstractThe polaronic effects at the atomic level hold paramount significance for advancing the efficacy of transition metal oxides in applications pertinent to renewable energy. The lattice–distortion mediated localization of photoexcited carriers in the form of polarons plays a pivotal role in the photocatalysis. This investigation focuses on rutile TiO2, an important material extensively explored for solar energy conversion in artificial photosynthesis, specifically targeting the generation of green H2 through photoelectrochemical (PEC) H2O splitting. By employing Hubbard‐U corrected and hybrid density functional theory (DFT) methods, we systematically probe the polaronic effects in the catalysis of oxygen evolution reaction (OER) on the (110) surface of rutile TiO2. Theoretical understanding of polarons within the surface, coupled with simulations of OER at distinct titanium (Ti) and oxygen (O) active sites, reveals diverse polaron formation energies within the lattice sites with strong preference for bulk and surface bridge (Ob) oxygen sites. Moreover, we provide the evidence for the facilitative role of polarons in OER. We find that hole polarons situated at the equatorial oxygen sites near the Ti–active site, along with bridge site hole polarons distal from the Ob active site yield a small reduction in OER overpotential by ~0.06 eV and ~0.12 eV, respectively. However, subsurface, equatorial, and bridge site hole polarons significantly reduce the Ti‐active site OER overpotential by ~0.4 eV through the peroxo–type oxygen pathway. We also observe that the presence of hole polarons stabilizes the *OH, *O, and *OOH intermediate species compared to the scenario without hole polarons. Overall, this study provides a detailed mechanistic insight into polaron–mediated OER, offering a promising avenue for improving the catalytic activity of transition metal oxide‐based photocatalysts catering to renewable energy requisites.
Getting Support for Adoption of Climate‐Smart 4R Practices
Authors: Bruulsema Tom , Ashford‐Kornburger Dana , Nigon Leanna , Menheere Nicole 
Published: March 2024

AbstractNutrient management, particularly for nitrogen, plays an important role in improving the carbon footprint of crop production. Many programs have recently expanded their offerings or funding levels of incentives to farmers to adopt more climate‐smart nutrient management practices. These programs provide opportunities for crop advisers to accelerate adoption among their clients of 4R practices that reduce greenhouse gas emissions and support soil carbon sequestration. The intent of this article is to provide a broad description of the programs available and the practices most likely to be effective. Earn 1.5 CEUs in Nutrient Management by reading this article and taking the quiz at https://web.sciencesocieties.org/Learning‐Center/Courses.