bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recommendations for the reporting and interpretation of isotope dilution U-Pb geochronological information
Authors: Condon Dan , Schoene Blair , Schmitz Mark , Schaltegger Urs , Ickert Ryan B. , Amelin Yuri , Augland Lars E. , Chamberlain Kevin R. , Coleman Drew S. , Connelly James N. , Corfu Fernando , Crowley James L. , Davies Joshua H.F.L. , Denyszyn Steven W. , Eddy Michael P. , Gaynor Sean P. , Heaman Larry M. , Huyskens Magdalena H. , Kamo Sandra , Kasbohm Jennifer , Keller C. Brenhin , MacLennan Scott A. , McLean Noah M. , Noble Stephen , Ovtcharova Maria , Paul André , Ramezani Jahandar , Rioux Matt , Sahy Diana , Scoates James S. , Szymanowski Dawid , Tapster Simon , Tichomirowa Marion , Wall Corey J. , Wotzlaw Jörn-Frederik , Yang Chuan , Yin Qing-Zhu 
Published: April 2024

Abstract
U-Pb geochronology by isotope dilution–thermal ionization mass spectrometry (ID-TIMS) has the potential to be the most precise and accurate of the deep time chronometers, especially when applied to high-U minerals such as zircon. Continued analytical improvements have made this technique capable of regularly achieving better than 0.1% precision and accuracy of dates from commonly occurring high-U minerals across a wide range of geological ages and settings. To help maximize the long-term utility of published results, we present and discuss some recommendations for reporting ID-TIMS U-Pb geochronological data and associated metadata in accordance with accepted principles of data management. Further, given that the accuracy of reported ages typically depends on the interpretation applied to a set of individual dates, we discuss strategies for data interpretation. We anticipate that this paper will serve as an instructive guide for geologists who are publishing ID-TIMS U-Pb data, for laboratories generating the data, the wider geoscience community who use such data, and also editors of journals who wish to be informed about community standards. Combined, our recommendations should increase the utility, veracity, versatility, and “half-life” of ID-TIMS U-Pb geochronological data.
Self-sampling with oral rinse to detect oropharyngeal
Neisseria gonorrhoeae
among men who have sex with men: results from an exploratory study in Belgium (the SSONG Study)
Authors: Vanbaelen Thibaut , van Petersen Lida , van Frankenhuijsen Maartje , Cuylaerts Vicky , Van den Bossche Dorien , Kenyon Chris , De Baetselier Irith 
Published: March 2024

Objectives

We aimed to assess whether a self-collected oral rinse was non-inferior to clinician-collected oropharyngeal swabs to detect
Neisseria gonorrhoeae
(Ng) using culture and nucleic acid amplification tests (NAAT) among men who have sex with men (MSM), and whether Ng may still be detected in oral rinses for a minimum of 5 days after collection.

Methods
MSM with a positive Ng result in an oropharyngeal or pooled sample (oropharynx, urethra and anorectum) were approached. Clinician-collected oropharyngeal swabs and oral rinses (15 mL sterile water) were taken. Ng culture and NAAT (Abbott 2000m RealTime System CT/NG assay and in-house PCR) were performed. Diagnostic accuracy was assessed using sensitivity and specificity, and agreement between both techniques using Cohen’s kappa statistic. Aliquots of positive oral rinses were left at room temperature for a minimum of 5 days and reanalysed using NAAT. Lastly, participants filled in a questionnaire to explore perceptions of both methods.

Results
We included 100 participants between June 2022 and October 2023. 45 individuals (45 of 100) had a positive Ng result in either the oral rinses (42 of 45, 93%) or the swabs (36 of 45, 80%). Sensitivity was higher for oral rinses than swabs (sensitivity=0.93/0.80, specificity=1.0/1.0, respectively) and agreement between both techniques was good (kappa=0.75, p<0.001). Of the 42 positive oral rinses, 37 remained positive after a minimum of 5 days (88.1%). Using culture, 18 individuals had a positive Ng result in either the oral rinses (8 of 18, 44%) or the swabs (16 of 18, 88%). Most participants found the oral rinse easy or very easy to use and would be willing to use the oral rinse for home-based sampling.

Conclusion
We detected more oropharyngeal Ng infections via NAAT using oral rinses than swab samples. However, swabs were better than oral rinses for culturing Ng. Oral rinses might allow for home-based self-sampling to detect oropharyngeal Ng.
Project Unplug - A Personal Reflection on Rediscovering the Joy in Being Online
Authors: Heron Michael James 
Published: April 2024

In 2021 I realised that large swathes of the Internet were making me sad. I resolved to do something about it.
The result was a focused, intense process of finding the mechanisms by which I could optimise my relationship with the online world. I resolved to focus on those things that brought me sustained happiness, as opposed to those things that merely offered transient pleasure. I ripped toxic websites out of my life, and limited my exposure to those I regarded as merely hazardous. The result was a battle to regain joy I once experienced in my online leisure activities - to regain my focus on electronic common ground, as opposed to digital battle grounds.
Few technologies have reached so deeply into our lives - and into our sense of self - as the modern Internet. Social and psychological defence mechanisms that evolved for the context of a tribe simply do not survive at Internet scale. For all that social media is designed to link us together, in many ways it only serves to push us apart.
This paper is a personal, autoethnographic reflection of how 'Project Unplug' was conceptualised, prepared, and executed over 2022. The specific combination of online vectors that were the cause of my unhappiness are unique to me.
This paper though outlines a hopefully valuable approach to creating our own digital rituals and rites so as to create strong, inviolable limits on the extent to which the Internet might erode our personal happiness
Supplementary Figure S4 from Human Tumor–Associated Macrophages and Neutrophils Regulate Antitumor Antibody Efficacy through Lethal and Sublethal Trogocytosis
Authors: Singhal Sunil , Rao Abhishek S. , Stadanlick Jason , Bruns Kyle , Sullivan Neil T. , Bermudez Andres , Honig-Frand Adam , Krouse Ryan , Arambepola Sachinthani , Guo Emily , Moon Edmund K. , Georgiou George , Valerius Thomas , Albelda Steven M. , Eruslanov Evgeniy B. 
Published: April 2024

<p>Supplementary Figure S4. (A) Cumulative results showing the kinetics of GFP+A431 tumor cell growth when co-cultured with PBN isolated from lung cancer patients at 50:1 E:T ratio in the presence of cetuximab (IgG) and IgA anti-EGFR Ab (IgA) using the IncuCyte® Live Cell Analysis System. One-way ANOVA with Turkey’s multiple comparisons test. Number of patients included in each analysis is indicated on the graphs. All data represented as mean ± SEM. (B) Cumulative results showing the kinetics of GFP+A431 tumor cell growth when co-cultured with blood and tumor FcR+ effectors for 48 hrs at 50:1 E:T ratio in the presence of IgA2 isotype control Abs in the IncuCyte® Live Cell Analysis System. One-way ANOVA with Dunnett's multiple comparisons test. All data represented as mean ± SEM. (C) Representative dotplots showing ADT mediated by TAM pretreated with cytohalasin D (1uM) or blocking anti-CD64 F(ab')2 and anti-CD32 F(ab')2 fragments (5ug/ml). TAM were co-cultured with PKH67+ A431 cells at a ratio 3:1 in the presence of cetuximab (1ug/ml) for 2 hrs. (D) Cumulative flow cytometry results showing the trogocytosis mediated by indicated blood and tumor myeloid effectors co-cultured with PKH67+A431 cells for 12 hrs at a 50:1 E:T ratio in the presence of IgG1 and IgA2 isotype control Abs (1ug/ml). Indicated FcR+ effectors were freshly isolated for all experiments.</p>
Ler e compreender a cidade: pressupostos para uma análise hermenêutica da herança material do espaço urbano
Authors: Sales Júnior Dário Ribeiro de 
Published: April 2024

The purpose of this article is to understand the theoretical assumptions underlying an urban hermeneutics. Here, we will focus on the implications of understanding the urban infrastructure and the buildings that were bequeathed to us by generations that preceded us in an analogous way to a text. therefore, we will seek to clarify some basic notions of Paul Ricoeur's hermeneutics. Furthermore, it will be possible to envision the advantages, in terms ofour relationship with the city, of considering the past as a “space of experience” and the future as a “horizon of expectations”, as suggested by Reinhart Koselleck. I believe that, like written discourse, the material heritage of cities has semantic autonomy and can be interpreted today in multiple ways by its readers. In this way, we can say that the actions that unfold in the historical present see the past as an inexhaustible source of resources and possibilities.
A Convolutional Neural Network for Tropical Cyclone Wind Structure Identification in Kilometer-Scale Forecasts
Authors: Raynaud L. , Faure G. , Puig M. , Dauvilliers C. , Trosino J.-N. , Béjean P. 
Published: April 2024

Abstract
Detection and tracking of tropical cyclones (TCs) in numerical weather prediction model outputs is essential for many applications, such as forecast guidance and real-time monitoring of events. While this task has been automated in the 1990s with heuristic models, relying on a set of empirical rules and thresholds, the recent success of machine learning methods to detect objects in images opens new perspectives. This paper introduces and evaluates the capacity of a convolutional neural network based on the U-Net architecture to detect the TC wind structure, including maximum wind speed area and hurricane-force wind speed area, in the outputs of the convective-scale AROME model. A dataset of 400 AROME forecasts over the West Indies domain has been entirely hand-labeled by experts, following a rigorous process to reduce heterogeneities. The U-Net performs well on a wide variety of TC intensities and shapes, with an average intersection-over-union metric of around 0.8. Its performances, however, strongly depend on the TC strength, and the detection of weak cyclones is more challenging since their structure is less well defined. The U-Net also significantly outperforms an operational heuristic detection model, with a significant gain for weak TCs, while running much faster. In the last part, the capacity of the U-Net to generalize on slightly different data is demonstrated in the context of a domain change and a resolution increase. In both cases, the pretrained U-Net achieves similar performances as the original dataset.
Program Factors Associated With Improved American Board of Surgery Examination Pass Rates
Authors: Ray Velez David 
Published: April 2024

Introduction The American Board of Surgery awards board certification after successful completion of both the Qualifying Exam and Certifying Exam. Although multiple studies have evaluated board performance at the resident level, fewer studies have evaluated board performance at the program level. Methods Program pass rates, available through the American Board of Surgery, for 2019-2021 were compared to program information through the American Medical Association Fellowship and Residency Electronic Interactive Database Access (FREIDA). Results A significant positive correlation of Certifying Exam performance to residency length, resident class size, and number of total physician faculty within the program was seen. Greater average hours of didactics per week had a significant positive correlation to improved Qualifying Exam performance but not Certifying Exam. Programs with higher percentages of residents graduating from a United States MD program, compared to international or DO schools, were associated with improved performances. It also appears that more established programs performed better than younger programs <20 years old. Programs in the West and Midwest performed significantly better on the Qualifying Exam than programs in the South and Northeast. Conclusion Board certification serves as the capstone for surgeons after completing general surgery residency. Multiple program factors demonstrate a significant correlation to board performance.
Service Sector Growth and Inequality in India: An Analysis of Household Consumption Spending
Authors: Talreja Chaitanya 
Published: April 2024

Two important aspects of service sector growth in India in the post-1991 reform period from the demand side have been identified in the literature. Ghose (2015) suggests that the rapid service demand expansion has been driven by the rich, who have disproportionately benefited from the information and communication technology (ICT)-based service boom. Basu and Das (2017) argue that service spending by the poorer section also rose, and the service demand expansion is partly a result of the coercive nature of privatised service expansion. This article examines these two critical aspects in greater detail using the National Sample Survey Organisation (NSSO) consumer expenditure surveys from 1993–94, 2004–05 and 2011–12. The article finds clear evidence to show that the service expenditure in India was dominated by the top 20% of Indian households. Even as bottom 20% devoted larger household budget share to services over time, their share in aggregate service expenditure remained marginal. State per capita income, servicification of output, social expenditure by the government, urbanisation and changing nature of the economy post liberalisation are found to be important factors associated with variation in household service expenditure share across quintile classes. The relationships of these factors with service expenditure share differ across expenditure quintiles. Further, service expenditure elasticity estimates by decile classes indicate more than unit elasticity for various services over time, depicting non-saturating demand for services. The decile-wide rise in demand for services during this period, especially for the poorer households, is possibly due to a complex mechanism involving necessity, aspirations and enhanced access to new services and may not fit into the binary of discretion versus involuntary spending. JEL Codes: O1, L16, L80, D30, D12
Family Caregiving of Patients With Heart Failure and Vascular Dementia in Rural Appalachia: A Mixed-Methods Study
Authors: Piamjariyakul Ubolrat , Wang Kesheng , Smith Marilyn , Young Stephanie , Shafique Saima , Navia R. Osvaldo , Williams Kristine 
Published: March 2024

Introduction: Vascular dementia and heart failure (HF) are common co-existing conditions among adult populations. Each condition requires extensive home caregiving from family caregivers, especially those in rural Appalachia. This study aimed to assess caregivers’ burden and their physical and mental health status, as well as explore their experiences and needs. Methods: This study used an exploratory mixed-methods design combining quantitative and qualitative research (N = 20 caregivers). We collected data using questionnaires, short-answered interviews, and focus group discussions. The multivariable generalized linear model (GLiM) was used to analyze quantitative data; content analysis was used for qualitative data. Results: The average age of family caregivers was 64.95 years. The generalized linear model showed that the caregiving burden was associated with caregivers’ depression/anxiety ( r = 0.68, P < .001) and their number of dementia caregiving years ( r = 0.54, P < .05). Caregivers’ poor physical health status was associated with better preparedness for HF and dementia home caregiving ( r = 0.52, P < .05) and male caregivers ( r = −0.46, P < .01). Caregivers’ mental health status was associated with depression/anxiety ( r = −0.80, P < .001). The qualitative data identified key caregiving themes: emotional impact and physical demands of caregiving, lack of help in rural areas, dealing with multiple disease progression, and relationship changes with their loved ones. Conclusion: Caregiving burden was associated with caregivers’ home care responsibilities and the need for support. Nurse-led home caregiving preparedness interventions tailored for family caregivers of patients with HF and dementia in rural areas are recommended.
The Importance of Medial Patellar Shape as a Risk Factor for Recurrent Patellar Dislocation in Adults
Authors: Sheehan Frances T. , Shah Paras , Boden Barry P. 
Published: April 2024

Background: Research on the cause of lateral patellar dislocation (LPD) has focused on trochlear morphologic parameters, joint alignment, and patellofemoral soft tissue forces. A paucity of information is available regarding how patellar morphologic parameters influence the risk for LPD. Purpose/Hypothesis: The purpose was to assess whether patellar morphology is a risk factor for recurrent LPD. It was hypothesized that (1) patients with recurrent LPD would have decreased patellar width and volume and (2) patellar morphologic parameters would accurately discriminate patients with recurrent LPD from controls. Study Design: Cohort study (diagnosis); Level of evidence, 3. Methods: A total of 21 adults with recurrent LPD (age, 29.7 ± 11.1 years; height, 170.8 ± 9.9 cm; weight, 76.1 ± 17.5 kg; 57% female) were compared with 21 sex- and height-matched controls (age, 27.2 ± 6.7 years; height, 172.0 ± 10.6 cm; weight, 71.1 ± 12.8 kg; 57% female). Three-dimensional axial fat-saturated magnetic resonance imaging scans were used to measure patellar medial, lateral, and total width; patellar volume; patellar medial and lateral facet length; the Wiberg index; and previously validated knee joint alignment and femoral shape measurements (eg, tibial tuberosity to trochlear groove distance, trochlear dysplasia). Results: The LPD group demonstrated reduced medial patellar width (Δ = −3.6 mm; P < .001) and medial facet length (Δ = −3.7 mm; P < .001) but no change in lateral width or facet length. This resulted in decreased total patellar width (Δ = −3.2 mm; P = .009), decreased patellar volume (Δ = −0.3 cm3; P = .025), and an increased Wiberg index (Δ = 0.05; P < .001). No significant differences were found for all other patellar shape measures between cohorts. Medial patellar width was the strongest single discriminator (83.3% accuracy) for recurrent LPD. Combining medial patellar width, patellofemoral tilt, and trochlear groove length increased the discrimination to 92.9%. Conclusion: The medial patellar width was significantly smaller in patients with recurrent LPD and was the single most accurate discriminator for recurrent LPD, even compared with traditional trochlear shape and joint alignment measures (eg, trochlear dysplasia, patella alta). Therefore, medial patellar morphology should be assessed in patients with LPD as a risk factor for recurrence and a potential means to improve treatment.
Estimating cost of prostate cancer management: an experience from Tanzania
Authors: Nyongole Obadia Venance , Kivuyo Nashivai Elias , Akoko Larry Onyango , Saronga Happiness , Kimu Njiku 
Published: April 2024

Abstract
Background
Prostate cancer (PC) is a significant public health problem affecting men worldwide and ranks third in incidence and mortality in East Africa. Cost of prostate cancer management is high in low-income countries because majority of patients presents with advanced (metastatic) PC. The cost related to management of PC including castrate resistant cancer in Tanzania has remained unknown; hence, policy makers do not have enough information for planning and resource allocation. This study therefore aimed to document costs related to the management of patients with prostate cancer including castrate resistant prostate cancer (CRPC) at Muhimbili National Hospital in Tanzania.

Methods
This was a retrospective descriptive hospital-based study which was conducted at Muhimbili National Hospital (MNH). Case notes of patients who were treated for prostate cancer were retrieved from medical records for review. A structured checklist was used to extract information regarding age, clinical presentation, investigations, stage of disease, type of treatment, payment modality and reimbursement. We considered data on the direct costs of prostate cancer management (diagnosis, treatment and follow-up) based on hospital price list of different categories. Costs reported were based on payment category in total and unit cost but also source of funding. Descriptive statistics were prepared and summarized as tables and figures.

Results
A total of 292 case notes of patients with prostate cancer were reviewed of which 189 patients received androgen deprivation therapy. Ninety-six (50.8%) met the criteria for the diagnoses of CRPC, and their mean age was 71.23 ± 4.2. Most of the patients had a poorly differentiated histology with prostate-specific antigen (PSA) over 100 ng/l. Bilateral orchiectomy was the most common treatment modality offered for advanced prostate cancer. Total cost for all PC patients was $148,136.4, equivalent to a unit cost per patient of $507.3. However, patients were in different categories of payment, 53% were public patients with an average cost of $471.3 per patient; 36.6% were cost sharing patients with an average cost of $441.8 per patient; 8.2% were National Health Insurance (NHIF) patients with an average cost of $893.8 per patient; and only 2.2% were private patients with an average cost of $1060.9 per patient.

Conclusion
Costs related to prostate cancer management need harmonization to accommodate different categories of patients in need.
MicroRNA-542-3p targets Pten to inhibit the myoblasts proliferation but suppresses myogenic differentiation independent of targeted Pten
Authors: Li Dandan , Yue Yongqi , Feng Xinxin , Lv Weibing , Fan Yilin , Sha Peiran , Zhao Te , Lin Yaqiu , Xiong Xianrong , Li Jian , Xiong Yan 
Published: April 2024

Abstract
Background
Non-coding RNA is a key epigenetic regulation factor during skeletal muscle development and postnatal growth, and miR-542-3p was reported to be conserved and highly expressed in the skeletal muscle among different species. However, its exact functions in the proliferation of muscle stem cells and myogenesis remain to be determined.

Methods
Transfection of proliferative and differentiated C2C12 cells used miR-542-3p mimic and inhibitor. RT-qPCR, EdU staining, immunofluorescence staining, cell counting kit 8 (CCK-8), and Western blot were used to evaluate the proliferation and myogenic differentiation caused by miR-542-3p. The dual luciferase reporter analysis and rescued experiment of the target gene were used to reveal the molecular mechanism.

Results
The data shows overexpression of miR-542-3p downregulation of mRNA and protein levels of proliferation marker genes, reduction of EdU+ cells, and cellular vitality. Additionally, knocking it down promoted the aforementioned phenotypes. For differentiation, the miR-542-3p gain-of-function reduced both mRNA and protein levels of myogenic genes, including MYOG, MYOD1, et al. Furthermore, immunofluorescence staining immunized by MYHC antibody showed that the myotube number, fluorescence intensity, differentiation index, and myotube fusion index all decreased in the miR-542-3p mimic group, compared with the control group. Conversely, these phenotypes exhibited an increased trend in the miR-542-3p inhibitor group. Mechanistically, phosphatase and tensin homolog (Pten) was identified as the bona fide target gene of miR-542-3p by dual luciferase reporter gene assay, si-Pten combined with miR-542-3p inhibitor treatments totally rescued the promotion of proliferation by loss-function of miR-542-3p.

Conclusions
This study indicates that miR-542-3p inhibits the proliferation and differentiation of myoblast and Pten is a dependent target gene of miR-542-3p in myoblast proliferation, but not in differentiation.