bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haemostatic and antialgic effects of the 25 mv photon beam concentrated dose in the treatment of carcinoma of the cervix
Authors: Patrício M. B. , Tavares M. A. , Guimarães M. F. , Belo M. C. , Vilhena M. 
Published: February 2007

AbstractThe authors present the results of a preliminary study on the use of a concentrated dose of 13 Gy in 48 hours in the treatment of cancer of the cervix, especially for haemostatic and antialgic purposes and mostly as a first part of a split course of radiotherapy. In 13 patients with early stages of the disease, the method was used as an emergency treatment with good response in 84.6% of the cases without serious complications. In 43 patients with advanced disease, the concentrated dose was generally repeated for palliation and relieved symptoms in about 72% of the cases but with complications in 16.3%. The authors recommend this method only when absolutely necessary to stop severe haemorrhage and suggest that patients with good response to the first flash course should continue treatment with conventional fractionation, bearing in mind the tolerance of the normal tissues.
Merkle cell carcinoma report of a case and possible role for adjuvant radiotherapy
Authors: Brown Pamela E. , Pinkston John A. , Blackmon John A. , McMahon John M. 
Published: February 2007

AbstractA case of neuroendocrine (Merkle cell) carcinoma of the skin is described. This uncommon tumor occurred in a 76‐year‐old female and presented as a small exophytic nodule on the right anterior chest wall. Following primary excision, it was thought to be a basal cell carcinoma. The diagnosis of Merkle cell carcinoma was established only after the tumor had recurred locally and involved ipsilateral axillary lymph nodes. Although local control was achieved with surgery and radiotherapy, the patient died of probable hepatic metastases 18 months after presentation. The Merkle cell tumor is an undifferentiated small cell carcinoma originating in the skin and has distinct ultrastructural characteristics that help to differentiate it from other small cell tumors. The clinicopathologic characteristics of these potentially aggressive neoplasms are reviewed, and treatment is briefly discussed.
Randomized trial of the addition of cis‐platin (DDP) and/or BCG to cyclophosphamide (CTX) chemotherapy for ovarian carcinoma
Authors: Wilbur David W. , Rentschler Robert E. , Wagner Robert J. , Keeney Elden D. , King Alan , Hilliard Dennis A. 
Published: February 2007

AbstractA prospective randomized trial has compared cyclophosphamide (CTX) with CTX plus cis‐diamminodichloroplatinum (DDP) as the initital chemotherapy for advanced ovarian carcinoma. A secondary randomization compared the addition of BCG treatment to either chemotherapy. The addition of DDP had no measurable impact on survival, but a small survival trend favoring BCG‐treated patients was noted (P < 0.08). Toxicity from BCG treatment was insignificant, but the addition of DDP increased both early nausea and vomiting and later hematologic toxicity. There were three long‐term complete remission patients, and these all came from the group of six patients with pretreatment residual disease < 2 cm. A univariate analysis of pretreatment prognostic factors indicated significantly better prognosis (P < 0.02) for patients with no palpable tumor, platelet count < 400,000/mm3, residual tumor < 2 cm, resting pulse < 91/min. and LDH < 250 U/L. The authors conclude that for patients with large (> 2 cm) residual disease, there is no compelling evidence that initial combination therapy is superior to aggressive single alkylating agent treatment.
Surgical treatment of bilateral synchronous wilms' tumors
Authors: Hanash K. A. , Sackey K. , Sabbah R. S. , Akhtar M. , Aur R. J. A. , Ali A. M. 
Published: February 2007

AbstractDefinite progress has been made in the treatment of bilateral Wilms' tumors with marked improvement in the prognosis. This is confirmed in our series of 6 consecutive patients with synchronous tumors. The recent trend toward more conservative surgery, double or triple drug chemotherapy, and avoidance of high‐dose radiation therapy has yielded good results.
Indolent lymphadenopathic Kaposi's sarcoma
Authors: Schwartz Robert A. , Brenden Lloyd D. , Breeden James H. , Lambert W. Clark 
Published: February 2007

AbstractKaposi's sarcoma is usually an indolent skin neoplasm. Diffuse lymph node and visceral involvement have been described in young African patients and in patients who are immunosuppressed; in such patients the disease is usually rapidly progressive. We describe the case of a 64‐year‐old man of Italian ancestry with diffuse lymph node involvement by Kaposi's sarcoma in the absence of any skin lesions. The patient had no evidence of immunosuppression. The course has been indolent, with no disease progression over 2 years of follow‐up on no therapy.
Effect of splenectomy on treatment of lewis lung carcinoma by an immunomodulatory polysaccharide and a cytotoxic agent
Authors: Michowitz Moshe , Kopel Shoshana , Hoenig Shoshana , Leibovici Judith 
Published: February 2007

AbstractThe effect of the spleen on the efficiency of chemotherapy (cyclophosphamide) and immunotherapy (the polysaccharide levan) of C57BL mice bearing the Lewis lung carcinoma was studied. The development of Lewis lung carcinoma caused a gradual splenomegaly in the C57BL mice. Splenectomy did not, however, affect tumor growth in the nontreated host. Levan induced a pronounced splenomegaly. Splenectomy reduced markedly the antitumoral effect of the polysaccharide. These results indicate that spleen elements participate in the inhibitory activity of levan. By contrast, splenectomy had no effect on the efficiency of treatment of cyclophosphamide.
Massive hemolysis in clostridium perfringens infections
Authors: Becker Richard C. , Giuliani Michael , Savage Richard A. , Weick James K. 
Published: February 2007

AbstractOver a 14‐month period at the Cleveland Clinic Foundation, 424 strains of Clostridium were isolated; of these, 52 strains were Clostridium perfringens isolated from 41 patients. Eight strains of C. perfringens were isolated from the blood of six patients; five of these patients had neoplastic disease and three developed massive intravascular hemolysis with rapidly developing shock and death. Clinical details are given on three patients with fatal Clostridium perfringens sepsis, and the nature of presentation and pathophysiologic mechanisms are discussed.
Renal cell carcinoma and vasculitis: Report of two cases
Authors: Hoag Gordon N. 
Published: February 2007

AbstractA 63‐year‐old caucasian male with systemic leukocytoclastic vasculitis involving the skin, lungs, and gastrointestinal tract was found to have a renal cell carcinoma at autopsy. A 77‐year‐old‐woman with a history of hypertension was felt to have temporal arteritis that was confirmed by biopsy. The autopsy revealed a renal cell carcinoma in association with widespread giant cell arteritis. The possible association of renal cell carcinoma with vasculitis and an assessment of the possible clinical usefulness are presented and cases of vasculitis with renal neoplasms are briefly reviewed.
Changing incidence of adenocarcinoma of the lung: A brief review
Authors: Reyes Cesar V. , Chua David , Aranha Gerald V. 
Published: February 2007

AbstractThe autopsy of lung cancer at Hines Veterans Administration Hospital was reviewed for a 27‐year period, between 1957 and 1983. There has been a changing histologic pattern with a recent increase in adenocarcinoma and a relative decrease of the other cell types. This observation, based on a virtually all‐male patient population, is partly attributed to better and improved diagnostic procedures.
Exclusion of small bowel from pelvis for postoperative radiotherapy for rectal cancer
Authors: Bakare Sanjivani C. , Shafir Michail , McElhinney A. James 
Published: February 2007

AbstractThe pelvis is the preferential site of disease when recurrence occurs after curative resection of rectal cancer. Postoperative adjuvant radiotherapy decreases local recurrence rates for Dukes stages B and C; however, after abdominoperineal or anterior resections, the small bowel descends into the lower pelvis, and, due to its low tolerance to radiation, optimal doses cannot be safely delivered unless the small bowel can be excluded from the pelvis. This can be achieved by cystopexy and/or by creating a pelvic sling with a knitted polypropylene mesh. Three cases are presented in which radiotherapy was satisfactorily delivered with these techniques.
Nodular liver lesions associated with chronic home hyperalimentation after massive enterectomy for ileal carcinoma
Authors: Kemeny M. Margaret 
Published: February 2007

AbstractA case of an ileal carcinoma involving the entire midgut treated with a massive enterectomy of the small bowel distal to the ligament of Treitz, the right colon, and part of the transverse colon is discussed. After 1 year on home hyperalimentation, hepatic nodules were seen on CT scans; metastases could not be proven. At 3 years a hepatic wedge resection was performed, multiple areas of necrosis and fibrosis were found, but no carcinoma. This case is presented as an example of an alternative in treatment for this type of carcinoma and to illustrate the problems of differential diagnosis of liver defects on the CT scan in patients on longterm hyperalimentation.
Carcinoma of the prostate clinically and radiologically simulating malignant lymphoma
Authors: Liel Yair , Biderman Aia , Biran Chaim , Katz Miriam , Sacks Martin 
Published: February 2007

AbstractA 65‐year‐old man presented with supraclavicular, mediastinal, and retroperitoneal lymphadenopathy clinically thought to be due to malignant lymphoma. Biopsy of a supraclavicular lymph node revealed metastatic adenocarcinoma positive for prostatic‐specific antigen. This site of the primary tumor was confirmed by needle biopsy of the prostate gland. The tumor regressed dramatically following treatment with estramustine phosphate.
Hydroxyurea plus pelvic radiation versus placebo plus pelvic radiation in surgically staged stage IIIB cervical cancer
Authors: Piver M. Steven , Vongtama Vitune , Emrich Lawrence J. 
Published: February 2007

AbstractForty‐five evaluable patients with stage IIIB carcinoma of the uterine cervix were entered into a prospective, double‐biind, randomized study to evaluate the possible radiation‐potentiating properties of hydroxyurea. All patients were documented to be without para‐aortic lymph node metastasis by pretherapy staging para‐aortic lymphadenectomy. The original plan of therapy was for continuous therapy (200 rads/day) of 6,000 rads of pelvic radiation for 6 weeks plus intrauterine radium. However, 16 patients received 6,000 rads in 8 weeks by split‐course therapy (2‐week rest after 3,000 rads) plus radium. Twenty‐nine patients received the planned continuous therapy. The median dose of pelvic radiation for patients who received continuous therapy or split‐course radiation was 6,000 rads. Leukopenia (WBC < 2,500/mm3) was significantly increased in the patients given hydroxyurea as compared to those given placebo (P < .001). There was no statistically significant difference relative to anemia, thrombocytopenia, radiation skin reaction, diarrhea, or radiation‐induced complications requiring surgical correction. The estimated 5‐year progression‐free survival rate for the combined, continuous, and split‐course radiation therapy hydroxyurea patients was 60 %, and its was 52 % for the corresponding placebo patients (P = .49). However, the estimated 5‐year progression free survival rate for the correctly treated patients (continuous therapy) was 91% for the hydroxyurea group and 60% for the placebo group (P < .06).
Metastatic disease in patients with newly diagnosed malignant melanoma
Authors: Zartman Gary M. , Thomas Mathew R. , Robinson William A. 
Published: February 2007

AbstractIn patients with stage I Clark's level III and IV malignant melanoma (MM), recurrence rates of 30‐60% can be expected after resection of the primary lesion. If metastatic disease could be detected early and treated in such patients, survival might be prolonged. Ninety patients (37 males and 53 females) with newly diagnosed, resected stage I cutaneous MM, levels III and IV, were evaluated for metastatic disease at diagnosis using a physical examination; CBC; SMA 18; chest films; brain computed tomography (CT) scan; and radioisotope liver, spleen, and bone scans. Fortyfour patients had level III and 46 had level IV melanomas ranging in thickness from 0.65 to 4.5 mm. None of these 90 patients was found to have metastatic disease. Such tests are not useful and can be replaced by a history and physical examination with substantially improved cost effectiveness.
Seeding and perineal implantation of prostatic cancer in the track of the biopsy needle: Three case reports and a review of the literature
Authors: Haddad Farid S. , Somsin Amporn A. 
Published: February 2007

AbstractSeveral months (an average of 12.86 months) after perineal needling of the cancerous prostate for the purpose of obtaining tissue for biopsy, a tumor nodule becomes clinically evident in the subcutaneous tissue of the perineum, at the site of the needling in 0.34% of the cases. This nodule presents the same histological picture as the biopsy of the prostatic tumor. This is a review of 15 such cases (12 collected from the literature and an additional three unpublished cases, two of which are personal observations). At the time of needling, no metastases could be clinically detected in any of the patients; the serum acid phosphatase was normal in 73% of them. The average age of the patients was 65‐66 years. The perineal nodule was tender in 40% of the cases; its average size was 2.5 cm. Excision of the nodule was the most frequently employed form of management. At the time of reporting, 60% of the patients were living and well, for an average of 18.56 months after excision. In order to prevent perineal implantation, especially in patients who are at risk, it is suggested that a fine needle be employed to obtain prostatic tissue for biopsy, and that every possible therapeutic effort be made.
Metastatic renal cell carcinoma simulating glumus jugulare tumor
Authors: Boileau Michel A. , Grotta James C. , Borit Adam , Linden Christiaan Van Der , Nath Avindra , Ostrow Peter , Kopaniky Dennis 
Published: February 2007

AbstractA 59‐year‐old man presented with jugular foramen syndrome caused by a mass with roentgenographic and histologic features highly suggestive of a glomus jugulare tumor. However, electron microscopic examination of the surgical specimen revealed features diagnostic of a previously unsuspected renal cell carcinoma. Because primary tumors of the glomus jugulare and metastatic renal cell carcinoma may present with the same clinical and roentgenographic findings and look similar histologically, careful electron microscopic examination of the tumor and urologic screening should be performed in suspected cases of glomus jugulare tumors.
Effects of serum immunosuppressive factors on antitumor cytotoxicity of interleukin 2‐induced lymphocytes
Authors: Sugiyama Yasuyuki , Sakata Kazuki , Saji Shigetoyo , Takao Hiroshi , Hamuro Junji 
Published: February 2007

AbstractThe cytotoxic ability of interleukin 2 (IL2)‐induced T cells and the effect on their cytotoxicity of serum suppressive factors obtained from cancer patients were examined. Peripheral blood mononuclear cells (PBL) of healthy adults were IL2‐cultured for 72 h either together with a gastric carcinoma cell line MKN‐28 or with phytohemagglutinin, then IL2‐cultured for another 11 days. Cytotoxicity of the MKN‐28 precultured lymphocytes against MKN‐28 was particularly increased. Presence during preculture or during cytotoxicity assay of sera from gastric cancer patients having the same histological type as MKN‐28 suppressed the cytotoxicity. However, the serum suppressive effect on cytotoxicity of the IL2‐cultured lymphocytes was far milder than that on PBL cytotoxicity.
Systemic rhabdomyosarcoma presenting as leukemia: Case report with ultrastructural study and reviews
Authors: Huntrakoon Manop , Callaway L. Alan , Vergara G. G. 
Published: February 2007

AbstractA 20‐year‐old white male was initially suspected clinically and pathologically of having an acute lymphoblastic leukemic process because of fatigue, severe anemia, thrombocytopenia, a leuko‐erythroblastic peripheral blood picture, and a diffusely infiltrated bone marrow. Subsequent review of the bone marrow material indicated cytologic features consistent with either an embryonal, undifferentiated small cell mesenchymal malignancy or reticulo‐endothelial malignancy. Ultimately, the electron microscopic (EM) study of the tumor proved to be diagnostic of rhabdomysoarcoma. An extensive search for a primary site of rhabdomyosarcoma did not show any lesion, although the genitourinary region was clinically suspected. The clinical course was a rapidly downhill one with extensive bone and CNS involvement. The patient died 5 months later. An autopsy permit was not obtained. This case emphasizes the occasional tendency of rhabdomyosarcoma to masquerade as a hematopoietic malignancy at the time of presentation and the usefulness of EM study in confirming a diagnosis.
Spontaneous penetration of dura mater and bone by glioblastoma multiforme
Authors: Shuangshoti Samruay , Kasantikul Vira , Suwanwela Nitaya 
Published: February 2007

AbstractThree patients are reported whose cranial dura mater and bones were penetrated by intracranial glioblastomas in the absence of previous craniotomy or radiotherapy. The gliomatous nature of the tumors was confirmed by localization of cytoplasmic glial fibrillary acidic protein (GFAP) of the neoplastic cells. Review of the literature disclosed only 15 glioblastomas, including the three cases, spontaneously penetrating the cranial dura mater and bones. These patients ranged in age from 3.5 to 70 years with an average age of 40 years. The male/female ratio was 5/8. Five glioblastomas were in the temporal lobes, three were in the frontal lobes, three were in the frontotemporal regions, two were in the occipital lobes, one was in the frontoparietal region, and one was in the temporoparietooccipital region. Six glioblastomas also had spontaneous distant metastases. In the absence of previous craniotomy and radiotherapy, rapid growth of the glioblastomas may promote such spontaneous penetration into the cranial dura mater and bones.
Primary adenocarcinoma of the esophagus
Authors: Steiger Zwi , Wilson Robert F. , Leichman Lawrence , Busuito Michael J. , Rosenberg J. C. 
Published: February 2007

AbstractOf 163 patients with carcinomas of the esophagus seen between 1975 and 1982, 11 (6.7%) had a primary adenocarcinoma. Although the high ratio of men to women (10:1) was similar to that seen in patients with squamous cell carcinoma of the esophagus, the mean age of those with adenocarcinoma was younger (57 years). In contrast to squamous cell carcinomas, which predominately involve blacks, esophageal adenocarcinomas in these patients involved only Caucasians. The great majority of lesions were found in the lower third of the esophagus. Only 3 (27%) of the patients with adenocarcinomas gave a history of a large daily alcohol consumption and only 2 (18%) had a Barrett's esophagus. Although various combinations of surgery, chemotherapy, and radiotherapy could control the primary tumor rather well, the final results were poor. All patients have now expired; median survival time was 16 months.
Proximal gastrectomy as the surgical procedure of choice for upper gastric carcinoma
Authors: Kaibara Nobuaki , Nishimura Okitsugu , Nishidoi Hideaki , Kimura Osamu , Koga Shigemasa 
Published: February 2007

AbstractTo assess the efficacy of proximal gastrectomy in the treatment of upper gastric carcinoma, we analyzed clinical data from patients with lesions confined to the upper third of the stomach (group 1) and from patients with lesions which, while primarily located in the upper portion of the stomach, showed spread to the body of the stomach (group 2). Patients in group 2 showed more metastatic lymph node involvement, particularly of the infrapyloric lymph nodes, which were not included in lymphadenectomy accompanying proximal gastrectomy. None of the group 1 patients demonstrated metastasis to the infrapyloric lymph nodes. The postoperative 5‐year survival rate in curatively operated group 1 patients was not significantly different between those treated by proximal gastrectomy and those subjected to total gastrectomy. We conclude that proximal gastrectomy is indicated in patients with upper gastric carcinoma when it is confined to the upper third of the stomach.
Nature of the spleen cell populations capable of releasing tumor enhancing factor
Authors: Eiján Ana María , Jasnis María Adela , Kohan Silvia S. , Oisgold‐Dagá Sara 
Published: February 2007

AbstractSupernatants obtained from short‐cultured spleen cells (SCS) from BALB/c mice bearing a syngeneic mammary transplanted tumor—S13—showed enhancing activity on tumor growth when inoculated into the foot pad of normal syngeneic mice 24 hr before injection of S13 tumor cells. The present work was designed to characterize the spleen cell population responsible for the releasing of the enhancing factor (EF) as long as the tumor grows (small tumor bearing mice—STEM—and large tumor bearing mice—LTBM). Pretreatment of spleen cells with anti‐Thy 1.2 serum + C' and nylon‐wool columns were utilized to separate cell populations and to characterize the cellular source of the enhancing activity in the spleens of STBM and LTBM. In this tumor system, evidence is presented for distinct enhancing cell populations operating in the spleens of STBM and LTBM. In early stages of tumor development, the EF was found to be associated with T and non‐T cells, whereas in advanced stages of tumor growth, this activity was found to be associated with only T cells.
Squamous cell carcinoma of the renal pelvis with sarcomalike stroma: A light and electron microscopic study with immunohistochemical analysis
Authors: Goldstein Jed , Mozes Marta , Lismer Leonid , Levin Israel 
Published: February 2007

AbstractPrimary neoplasms of the renal pelvis are rare. Most are malignant, and most of these are transitional cell carcinomas. We report the unusual occurrence of a squamous cell carcinoma with sarcomatoid stroma arising from the renal pelvic mucosa in a patient with renal lithiasis. Immunohistochemical stains for keratin intermediate filaments failed to demonstrate their presence in the spindle cell portion of the tumor. Transmission electron microscopic study did not reveal structures of an epithelial nature in these same cells. Our findings support the contention that the spindle cells of the stroma are not squamous in nature, but represent either a reactive or a neoplastic transformation of these underlying stromal elements.
Tumor‐induced osteomalacia: Long‐term follow‐up of two patients cured by removal of their tumors
Authors: Sparagana Mario 
Published: February 2007

AbstractTwo patients with mesenchymal tumors had osteomalacia associated with marked hypophosphatemia and renal phosphate wasting. Their serum calcium and parathyroid hormone levels were normal. The first patient also had aminoaciduria and glucosuria in addition to phosphaturia. Both patients were treated with very large doses of vitamin D2 and phosphate without improvement in the osteomalacia or normalization of the serum phosphate. Complete removal of a low‐grade fibrosarcoma in the second patient and removal of an ossifying fibroma in the first patient resulted in a cure in both patients despite no further therapy with vitamin D or phosphate. The excessive aminoaciduria and glucosuria of the first patient also remitted. During a 14‐year follow‐up period, there has been no evidence of tumor recurrence, hypophosphatemia, or osteomalacia in either patient. The levels of 1,25‐dihydroxycholecalciferol remain within the normal range in both patients.