bluuebunny/crossref_metadata_2025_split huggingface dataset:
Game Edukasi Berbasis Artificial Intelligenci Untuk Mengenal Tokoh Pahlawan Nasional Dalam Rangka Meningkatkan Pengetahuan Sejarah Indonesia
Authors: Jimly Ash Sidiq  , Kaslani Kaslani , Pratama Denni 
Published: March 2024

Edukasi sejarah merupakan suatu aspek penting di dalam pendidikan karena bidang ini merupakan hal yang terjadi di masa lalu dan membentuk keadaan dunia sehingga dapat menjadi seperti sekarang ini. Ada banyak cara untuk melakukan edukasi sejarah, mulai dari pembelajaran melalui metode konvensional, yaitu dengan melakukan pembelajaran edukasi sejarah di kelas hingga melalui metode yang cukup digemari oleh siswa tingkat Sekolah Dasar. tujuan penulisan ini ialah untuk melakukan rancangan game edukasi berbasis sejarah yang telah dibuat dalam storyline yang digunakan dalam penelitian sebelumnya dan bagaimana hasil penelitian tersebut. Tahapan dalam peneltian ini Model ADDIE yaitu Analysis, Design, Development, Implementation, dan Evaluation. Hasil dari peneltian ini Game edukasi sejarah tokoh nasional sebagai sarana permainan dan pembelajaran yang mudah dan menarik untuk anak dan berdasarkan hasil uji hipotesis setelah dilakukan perhitungan menggunakan spss didapatkan t-hitung sebesar 27.528, dan t-table sebesar 2.0484 dimana didapatkan Ha diterima dan H0 ditolak
Analisis Klaster Kualitas Air Berdasarkan Baku Mutu Menggunakan Metode K-Means
Authors: Sopyan  
Published: March 2024

Pltu 1 merupakan industri pembangkit listrik yang mengelola air limbah domestik sendiri dengan berdasarkan baku mutu. Penelitian ini bertujuan untuk menganalisis kualitas buangan air diInstalasi Pengolahan Air limbah(IPAL) Tujuan dari penelitian ini, peneliti ingin mengetahui kandungan pencemar air di Area pltu. Untuk mengetahui kandungan pencemar yang tinggi ataupun rendah pada kandungan pencemar dapat dilakukan clustering menggunakan metode kmeans. Tahapan penelitian ini peneliti melakukan penelitian, selanjutnya setelah data di dapat kemudian peneliti mengumpulkan jumlah data perharinya. Tahap ketiga peneliti melakukan preprosesing data. Tahap keempat peneliti melakukan transformasi data sehingga data dapat diolah menggunakan aplikasi rapid miner. Tahap kelima peneliti melakukan clustering menggunakan metode k-means, pada tahap ini peneliti mencari beberapa jumlah cluster dengan k terbaik dimulai dari cluster k-2 hingga cluster k-3. Hasil dari penelitian ini diperoleh cluster terbaik yaitu cluster_1 dan cluster_2 dengan hasil pH yang memiliki tinggat ke basahan tinggi terpadat pada Area pltu disusul BOD, COD dan yang terakhir adalah TSS.
Sistem Informasi Seleksi Calon Anggota Paskibraka Menggunakan Metode Profile Matching
Authors: Pratama Denni , Rahaningsih Nining , Muhamad Basysyar Fadhil , Yahya Moh. 
Published: March 2024

Seleksi calon anggota pasukan pengibar bendera pusaka (Paskibraka) adalah suatu kegiatan yang dilaksanakan oleh Dinas Pemuda dan Olahraga (Dispora) Kota Cirebon setiap tahunnya yang bertujuan untuk mencari putra putri terbaik dari masing-masing sekolah tingkat SMA/sederajat yang akan ditugaskan sebagai pengibar bendera pusaka di Balai Kota Cirebon pada perayaan Hari Ulang Tahun Republik Indonesia (HUT RI). Seleksi yang sangat ketat memicu adanya ketidakterbukaan dari panitia. Menurut Permenpora No 14 Tahun 2017 tentang program pasukan pengibar bendera pusaka syarat peserta sudah jelas kriterianya. Tahap penentuan calon peserta membutuhkan waktu untuk memutuskan dari ratusan peserta yang diambil hanya 32 peserta terdiri dari 16 laki - laki dan 16 wanita. Secara administrasi syarat calon peserta sudah tertuang dalam aturan pemerintahan namun dalam pelaksanaan sering terjadi adanya kriteria tanpa ada acuan pada peraturan daerah. Permasalahan yang muncul hasil test yang dilaksanakan direkap secara manual hal ini membutuhkan banyak waktu untuk mengambil keputusan calon anggota yang akan ditugaskan dalam peringatan HUT RI tingkat Kota. Sistem Pendukung Keputusan (SPK) diimplementasikan pada permasalahan seleksi calon peserta anggota Paskibraka di Kota Cirebon. Adanya kriteria dan aspek pada syarat bisa dimungkinkan untuk menggunakan metode Profile Matching. Ketentuan-ketentuan yang diterapkan pada lead menjadi acuan untuk pencocokan profile. Nilai Gap, Core Factor dan Secondary Factor mempengaruhi perangkingan. Nilai total dari perangkingan akan memutuskan dan memberikan rekomendasi peserta seleksi sebagai anggota Paskibaraka.
Klasifikasi Citra Daun Mangga Menggunakan Algoritma Support Vector Machine
Authors: Isnansyah Gabril , Ngii Katharina Amelia , Adi Saputra Rizal 
Published: March 2024

Daun adalah bagian yang paling banyak dimiliki oleh tumbuhan mulai dari tumbuh kecil sampai yang pohon yang tinggi dan besar. Daun adalah bagian dari tumbuhan yang berfungsi sebagai tempat fotosintesis terjadi. Support Vector Machine (SVM) adalah salah satu algoritma machine learning dengan yang menggunnakan pendekatan yang berbasis pada supervised learning yang dapat digunakan untuk masalah klasifikasi dan regresi.
Epidemiological Determinants and Trend Analysis of Dengue Fever Disease
Authors: Sutriyawan Agung , Suherdin Suherdin , Kurniawati Ratna Dian 
Published: March 2024

Bandung City is an endemic area for dengue fever, with 4,424 cases and 14 deaths. This research aims to analyze the epidemiological determinants and see the trend analysis to forecast dengue hemorrhagic fever cases. This research used a case-control design. The case population was those who suffered from dengue hemorrhagic fever, while the control population was those who did not suffer from dengue hemorrhagic fever. A sample of 510 respondents was taken. Sampling using a purposive sampling technique. Epidemiological determinants were analyzed using the chi-square test and logistic regression, while disease trends used exponential smooth analysis. The related results were education (p=0.036), presence of mosquito larvae (p=0.000), container material (p=0.002), water container (p=0.025), mosquito wire (p=0.010), presence of solid waste (p=0.002), mosquito repellent plants (p=0.041), mobility (p=0.004). The most dominant epidemiological determinant was the presence of mosquito larvae (OR=3.2). The incidence trend of dengue fever is increasing over the next 5 years. The research concluded that the epidemiological determinants of dengue fever were education, the presence of mosquito larvae, container materials, water collection objects, mosquito wires, the presence of solid waste, and mosquito repellent plants. The presence of mosquito larvae was the dominant factor. There is an increase in dengue fever cases over the next 5 years. It is recommended to increase the larva-free rate by optimizing Jumantik cadres and conducting epidemiological surveillance.
Causal relationship between the gut microbiota and insomnia: a two-sample Mendelian randomization study
Authors: Wang Qianfei , Gao Tianci , Zhang Weichao , Liu Dong , Li Xin , Chen Fenqiao , Mei Jianqiang 
Published: March 2024

BackgroundChanges in the gut microbiota are closely related to insomnia, but the causal relationship between them is not yet clear.ObjectiveTo clarify the relationship between the gut microbiota and insomnia and provide genetic evidence for them, we conducted a two-sample Mendelian randomization study.MethodsWe used a Mendelian randomized two-way validation method to discuss the causal relationship. First, we downloaded the data of 462,341 participants relating to insomnia, and the data of 18,340 participants relating to the gut microbiota from a genome-wide association study (GWAS). Then, we used two regression models, inverse-variance weighted (IVW) and MR-Egger regression, to evaluate the relationship between exposure factors and outcomes. Finally, we took a reverse MR analysis to assess the possibility of reverse causality.ResultsThe combined results show 19 gut microbiotas to have a causal relationship with insomnia (odds ratio (OR): 1.03; 95% confidence interval (CI): 1.01, 1.05; p=0.000 for class. Negativicutes; OR: 1.03; 95% CI: 1.01, 1.05; p=0.000 for order.Selenomonadales; OR: 1.01; 95% CI: 1.00, 1.02; p=0.003 for genus.RikenellaceaeRC9gutgroup). The results were consistent with sensitivity analyses for these bacterial traits. In reverse MR analysis, we found no statistical difference between insomnia and these gut microbiotas.ConclusionThis study can provide a new direction for the causal relationship between the gut microbiota (class.Negativicutes, order.Selenomonadales, genus.Lactococcus) and insomnia and the treatment or prevention strategies of insomnia.
Transcriptome analysis of genes involved in the pathogenesis mechanism of potato virus Y in potato cultivar YouJin
Authors: Yang Tianqi , Zhao Xingyue , Bai Jinjiang , Lv Wenxia , Chen Qi , Hu Jun , Liu Guangjing , Zhao Yuanzheng , Zhou Hongyou , Zhao Mingmin , Zheng Hongli 
Published: March 2024

IntroductionPotatoes (Solanum tuberosum L.) can be infected by various viruses, but out of all of viruses, the potato virus Y (PVY) is the most detrimental. Research shows that the potato cultivar YouJin is especially vulnerable to PVY and displays severe symptoms, including leaf vein chlorosis, curled leaf margins, large necrotic spots on the leaf blades, and the growth of small new leaves.MethodsPVY infection in potato cultivar YouJin was confirmed through symptom observation, RT-PCR, and Western blot analysis. Transcriptome sequencing was used to analyze the genes associated with PVY pathogenesis in this cultivar.ResultTranscriptome analysis of differential genes was conducted in this study to examine the pathogenesis of PVY on YouJin. The results showed that 1,949 genes were differentially regulated, including 853 upregulated genes and 1,096 downregulated genes. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis indicated that carbohydrate synthesis and metabolism pathways were suppressed, and electron transferase and hydrolase activities were reduced. Moreover, there were increased expression levels of protein kinase genes. By focusing on plant–pathogen interaction pathways, six core genes all upregulating the WARK family of transcription factors were obtained. Additionally, a constructed PPI network revealed the identification of key modular differential genes, such as downregulated photosynthesis-related protein genes and upregulated AP2/ERF-ERF transcription factors. Functional network enrichment analysis revealed that PVY infection limited RNA metabolism, glutathionylation, and peroxiredoxin activity while triggering the expression of associated defense genes in YouJin. After analyzing the above, 26 DEGs were screened and 12 DEGs were confirmed via RT-qPCR.ConclusionThese results establish a hypothetical framework for clarifying the pathogenesis of PVY in the YouJin variety of potatoes, which will help design the disease resistance of YouJin.
A multiplex RPA coupled with CRISPR-Cas12a system for rapid and cost-effective identification of carbapenem-resistant Acinetobacter baumannii
Authors: Zhou Zihan , Liang Lina , Liao Chuan , Pan Lele , Wang Chunfang , Ma Jiangmei , Yi Xueli , Tan Meiying , Li Xuebin , Wei Guijiang 
Published: March 2024

BackgroundCarbapenem-resistant Acinetobacter baumannii (CRAB) poses a severe nosocomial threat, prompting a need for efficient detection methods. Traditional approaches, such as bacterial culture and PCR, are time-consuming and cumbersome. The CRISPR-based gene editing system offered a potential approach for point-of-care testing of CRAB.MethodsWe integrated recombinase polymerase amplification (RPA) and CRISPR-Cas12a system to swiftly diagnose CRAB-associated genes, OXA-51 and OXA-23. This multiplex RPA-CRISPR-Cas12a system eliminates bulky instruments, ensuring a simplified UV lamp-based outcome interpretation.ResultsOperating at 37°C to 40°C, the entire process achieves CRAB diagnosis within 90 minutes. Detection limits for OXA-51 and OXA-23 genes are 1.3 × 10−6 ng/μL, exhibiting exclusive CRAB detection without cross-reactivity to common pathogens. Notably, the platform shows 100% concordance with PCR when testing 30 clinical Acinetobacter baumannii strains.ConclusionIn conclusion, our multiplex RPA coupled with the CRISPR-Cas12a system provides a fast and sensitive CRAB detection method, overcoming limitations of traditional approaches and holding promise for efficient point-of-care testing.
Positive effect of microvascular proliferation on functional recovery in experimental cervical spondylotic myelopathy
Authors: Wang Xu-xiang , Li Guang-sheng , Wang Kang-heng , Hu Xiao-song , Hu Yong 
Published: March 2024

Background and purposeCervical Spondylotic Myelopathy (CSM), the most common cause of spinal cord dysfunction globally, is a degenerative disease that results in non-violent, gradual, and long-lasting compression of the cervical spinal cord. The objective of this study was to investigate whether microvascular proliferation could positively affect neural function recovery in experimental cervical spondylotic myelopathy (CSM).MethodsA total of 60 male adult Sprague–Dawley (SD) were randomly divided into four groups: Control (CON), Compression (COM), Angiostasis (AS), and Angiogenesis (A G),with 15 rats in each group. Rats in the AS group received SU5416 to inhibit angiogenesis, while rats in the AG group received Deferoxamine (DFO) to promote angiogenesis. Motor and sensory functions were assessed using the Basso Beattie Bresnahan (BBB) scale and somatosensory evoked potential (SEP) examination. Neuropathological degeneration was evaluated by the number of neurons, Nissl bodies (NB), and the de-myelination of white matter detected by Hematoxylin &amp; Eosin(HE), Toluidine Blue (TB), and Luxol Fast Blue (LFB) staining. Immunohistochemical (IHC) staining was used to observe the Neurovascular Unit (NVU).ResultsRats in the CON group exhibited normal locomotor function with full BBB score, normal SEP latency and amplitude. Among the other three groups, the AG group had the highest BBB score and the shortest SEP latency, while the AS group had the lowest BBB score and the most prolonged SEP latency. The SEP amplitude showed an opposite performance to the latency. Compared to the COM and AS groups, the AG group demonstrated significant neuronal restoration in gray matter and axonal remyelination in white matter. DFO promoted microvascular proliferation, especially in gray matter, and improved the survival of neuroglial cells. In contrast, SU-5416 inhibited the viability of neuroglial cells by reducing micro vessels.ConclusionThe microvascular status was closely related to NVU remodeling an-d functional recovery. Therefore, proliferation of micro vessels contributed to function -al recovery in experimental CSM, which may be associated with NVU remodeling.
Knowledge, attitudes, and practices of vaccinators about expanded programs on immunization: a cross-sectional study
Authors: Azhar Sunia , Rashid Laiba , Islam Taskeen , Akhtar Samar , Hopkins Kathryn L. , Sommers Theresa , Ikram Aamer , Anwer Naveed , Maqbool Nabeel Ahmed , Khan Zakir , Ahmed Naveed , Akhtar Hashaam 
Published: March 2024

IntroductionThe periodic evaluation of knowledge, attitudes, and practices (KAP) of healthcare workers, including vaccinators, concerning expanded programs on immunization (EPI) is very crucial for a better healthcare system. This study was carried out to assess the KAP of vaccinators about the EPI, including cold storage of vaccines and their practices related to vaccine cold chain management.MethodA cross-sectional study was conducted from January 2022 to June 2022 among registered vaccinators in the twin cities (Islamabad and Rawalpindi) of Pakistan. A structured self-administered questionnaire (English and Urdu) was developed as per the Pakistan national EPI policy and strategic guidelines 2022 and World Health Organization (WHO) guidelines, as well as from earlier studies (Cronbach's alpha value of 0.734). The final questionnaire consisted of closed-ended questions in four sections, including sociodemographic information, knowledge (with dichotomous variables of yes/no), attitudes (with a 5-point Likert scale ranging from strongly agree to strongly disagree), and handling of vaccines and cold chain management. Completed questionnaires were entered into Microsoft Excel and then imported into SPSS version 25 for statistical analysis.ResultsA total of 186 vaccinators completely filled out their questionnaires, with a 97.9% response rate. More than half of the participants (57.5%) had no training related to EPI. Most of the respondents had a moderate to poor level of knowledge regarding EPI. The overall attitude was positive, and 57% of the participants strongly agreed that the national immunization programs can significantly contribute to the decrease in morbidity and mortality rates among children. In the current study, participants showed good practices toward EPI, vaccine storage, and cold chain management. The majority (93.5%) of the participants checked the expiry of vaccines at regular intervals to maintain the first expiry first out (FEFO) in their healthcare setting.DiscussionIn conclusion, most of the vaccinators had moderate to poor knowledge, a positive attitude, and good practices toward EPI, vaccine cold storage, and cold chain management. Lack of training among vaccinators on EPI was also observed. These findings have suggested that continuous training, education, and regular supervision of vaccinators in EPI are important for maximum immunization effectiveness and coverage.
A qualitative study of the implementation and organization of the national Greenlandic addiction treatment service
Authors: Flyger Julie , Larsen Christina Viskum Lytken , Jensen Else , Niclasen Birgit , Nielsen Anette Søgaard 
Published: March 2024

BackgroundAlcohol and cannabis use constitutes the major public health problems in Greenland. Thus, it is important to assess if Allorfik, a new national outpatient addiction treatment service introduced in 2016, was implemented successfully and how it is perceived. Allorfik introduced local treatment centers offering a treatment methodology (motivational interviewing and cognitive therapy) new to addiction treatment in Greenland with limited evidence from Indigenous populations such as the Greenlandic. The present study investigates the implementation of Allorfik from the perspective of those engaged in the process and the field.MethodsData consisted of transcribed interviews with 23 individuals from both Allorfik and organizations collaborating with or supposed to collaborate with Allorfik. The theme of the interviews was their perspectives on the implementation process, enablers, and obstacles in the process and how Allorfik was performing at the time of the interview. The interview guide was informed by implementation theory. The transcribed material was analyzed using a general inductive approach.ResultsThe analysis resulted in three overall and interconnected themes, namely, implementation, collaborations, and challenges. The implementation was overall considered a success by the interviewees as all components were implemented as planned with a few adaptions, e.g., a treatment guideline update. The collaborations are considered challenging but important to all interviewees. Collaborations seem to rely on personal commitment as opposed to well-defined structures, making it unstable and vulnerable to changes in staff. One of the main challenges highlighted by the interviewees is the number of problems other than addiction among people in treatment, which makes addiction treatment and recovery difficult to achieve. Nevertheless, the high levels of other problems being treated in Allorfik highlights the need for easily accessible therapy as many find that Allorfik is the only place to turn to in times of crisis.ConclusionAllorfik seems to have been implemented in accordance with original intentions and plans for addiction treatment service but has also become more than just a service for addiction treatment with easy access in a country with vast distances and limited resources.
Gambaran Penggunaan Obat Antipendarahan dan Antinyeri pada Pasien Rawat Inap Kanker Serviks Di Rumah Sakit X Wilayah Kota Gorontalo Periode 2021-2022
Authors: Papeo Dizky Ramadani putri , Samatowa Rahmatia , Silaka Nur'ain Dj. , Sabihi Andini Putri , Arini Arini , Salam Nurhayati , Ahmad Abd. Ghiaz Putra Ramadan 
Published: March 2024

Kanker serviks atau kanker rahim merupakan keganasan dari leher rahim (serviks) yang dapat disebabkan karena adanya virus HPV (Human papiloma virus). Data dari World Health Organization (WHO) diketahui terdapat 493.243 jiwa pertahunpenderita kanker serviks baru dengan angka kematian sebanyak 273.505 jiwa pertahun. Tujuan dari penelitian ini yaitu untuk mengetahui gambaran penggunaan obat antipendarahan dan antinyeri pada pasien kanker serviks di rumah sakit “X”. Penelitian ini menggunakan metode deskriptif retrospektif dengan populasi 8 pasien yang terdiagnosa kanker serviks di rumah sakit “X” di wilayah Kota Gorontalo periode 2021-2022. Berdasarkan hasil penelitian terdapat pasien kanker serviks yang menjalani rawat inap di rumah sakit “X” wilayah kota Gorontalo diketahui bahwa antinyeri yang paling banyak digunakan yaitu asam mefenamat dengan persentase 6,67% dengan dosis 500 mg, Fibrinolitik yang paling banyak digunakan di rumah sakit “X” yaitu asam tranexamat dengan dosis 500 mg.
Pengaruh Waktu Pengeringan Beku (Freeze Drying) Terhadap Evaluasi Fisik Sediaan Gel Bunga Telang (Clitoria ternatea L.) dengan Variasi HPMC
Authors: Pratiwi Anisa Nur Pratiwi , Saputri Gusti Ayu Rai , Ulfa Ade Maria 
Published: March 2024

Bunga telang (Clitoria ternatea L.) merupakan salah satu tanaman yang memiliki manfaat fungsional bagi tubuh manusia. Salah satu penyebab kerusakan senyawa pada bunga telang dikarenakan suhu tinggi (pemanasan) yang biasa digunakan pada saat proses pengeringan. Freeze drying merupakan salah satu metode pengeringan tanpa melalui pemanasan. Setelah mendapat ekstrak dapat dilanjutkan dengan formulasi. Formulasi sediaan gel membutuhkan basis yang mampu menyatukan seluruh komponen seperti gelling agent HPMC. Tujuan dari penelitian ini yaitu untuk menentukan konsentrasi gelling agent HPMC dan untuk mengetahui pengaruh perbedaan waktu pengeringan. Metode ekstraksi yang digunakan dalam penelitian ini yaitu metode maserasi dengan pelarut aquadest (1:10). Hasil maserasi kemudian dimasukkan ke dalam pendingin hingga didapatkan ekstrak beku kemudian dilakukan freeze drying guna menghilangkan kadar air. Hasil rendemen yang diperoleh pada waktu pengeringan 36 jam adalah 40% dengan kadar air 9% dan rendemen yang diperoleh pada waktu pengeringan 48 jam adalah 27,5% dengan kadar air 8%. Sediaan gel ekstrak bunga telang memenuhi persyaratan uji evaluasi fisik standar SNI 16-4399-1996 pada uji pH, daya sebar, daya lekat dan viskositas. Analisis data dilakukan dengan menggunakan (two-way ANOVA). Hasil analisis statistik menunjuk kan bahwa variasi lama waktu pengeringan ekstrak dengan basis HPMC memiliki pengaruh signifikan pada uji pH dan uji viskositas dengan nilai P-value <0,05.