bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Role of Hyaluronic Acid in Reproductive Biology and Beyond: Applications in Assisted Reproduction and Tissue Engineering
Authors: Rashki Ghaleno Leila , Pennisi Cristian Pablo , Shahverdi Abdolhossein , Dardmeh Fereshteh , Alipour Hiva , Rezazadeh Valojerdi Mojtaba 
Published: April 2024

AbstractHyaluronic acid (HA) plays a prominent role in various aspects of reproductive biology and assisted reproductive technologies (ART). This review describes the multifaceted influence of HA, ranging from primordial germ cell migration, ovarian follicle development, and ovulation in females to sperm structure, physiology, motility, and capacitation in males. In addition, HA also plays an important role in fertilization and promotes embryo implantation by mediating cellular adhesion and communication within the uterus. Against this physiological background, the review examines the current applications of HA in the context of ART. In addition, the article addresses the emerging field of reproductive tissue engineering, where HA‐based hydrogels offer promising perspectives as they can support the development of mature oocytes and spermatogenesis in vitro. Overall, this review highlights the integral role of HA in the intricate mechanisms of reproductive biology and its growing importance for improving ART outcomes and the field of tissue engineering of the reproductive system.
A Library of Nanocrystal‐Inserted Ordered Mesoporous Frameworks with Ultrahigh Density and Spatial Dispersity
Authors: Zhang Wei , Shi Wenxiong , Wang Jinxiu , Zhu Kerun , Tian Yong , He Haili , Duan Linlin , Fang Huang , Liu Yupu , Wang Biwei , Ma Yuzhu , Zhao Tiancong , Zhang Xingmiao , Lv Zirui , Zu Lianhai , Tang Yun , Dong Angang , Kong Biao , Zhao Dongyuan 
Published: April 2024

AbstractIt is a great challenge to integrate incompatible subunits into ordered macroscopic materials with tailored functionalities. Herein, a facile modular assembly strategy is demonstrated to link incompatible colloidal nanocrystals and polymer micelles by using the phenolic resol as the “molecule glue” for the synthesis of nanocrystal‐inserted mesoporous frameworks with diverse functionalities. It is found that the uniform nanocrystals can be inserted into the mesoporous frameworks with outstanding spatial dispersity, even in the case of high incorporation density. This modular assembly route is versatile, a library of nanocrystals with diverse diameters, shapes, and compositions can be integrated into various kinds of mesoporous frameworks (carbon, carbon‐SiO2, and carbon‐TiO2 composites). Unprecedently, this strategy also allows the controllable assembly of two, even three types of nanocrystals within the mesoporous frameworks to achieve multiple functionalities. The as‐prepared nanocomposites can simultaneously exhibit catalytic, magnetic, and adsorption properties independently, and show synergistic effects for tandem catalytic applications.
Observing Proton–Electron Mixed Conductivity in Graphdiyne
Authors: Li Jiaofu , Wang Cong , Su Jiangtao , Liu Zhihua , Fan Hangming , Wang Changxian , Li Yanzhen , He Yongli , Chen Nuan , Cao Jinwei , Chen Xiaodong 
Published: April 2024

AbstractMixed conducting materials with both ionic and electronic conductivities have gained prominence in emerging applications. However, exploring material with on‐demand ionic and electronic conductivities remains challenging, primarily due to the lack of correlating macroscopic conductivity with atom‐scale structure. Here, the correlation of proton–electron conductivity and atom‐scale structure in graphdiyne is explored. Precisely adjusting the conjugated diynes and oxygenic functional groups in graphdiyne yields a tunable proton–electron conductivity on the order of 103. In addition, a wet‐chemistry lithography technique for uniform preparation of graphdiyne on flexible substrates is provided. Utilizing the proton–electron conductivity and mechanical tolerance of graphdiyne, bimodal flexible devices serving as capacitive switches and resistive sensors are created. As a proof‐of‐concept, a breath–machine interface for sentence‐based communication and self‐nursing tasks with an accuracy of 98% is designed. This work represents an important step toward understanding the atom‐scale structure–conductivity relationship and extending the applications of mixed conducting materials to assistive technology.
Precision Calcination Mechanism of CaCO3 to High‐Porosity Nanoscale CaO CO2 Sorbent Revealed by Direct In Situ Observations
Authors: Martinez Jenny , Wardini Jenna L. , Zheng Xueli , Moghimi Lauren , Rakowsky Jason , Means Jonathan , Guo Huiming , Kuzmenko Ivan , Ilavsky Jan , Zhang Fan , Dholabhai Pratik P. , Dresselhaus‐Marais Leora , Bowman William J. 
Published: April 2024

AbstractDeploying energy storage and carbon capture at scale is hindered by the substantial endothermic penalty of decomposing CaCO3 to CaO and CO2, and the rapid loss of CO2 absorption capacity by CaO sorbent particles due to sintering at the high requisite decomposition temperatures. The decomposition reaction mechanism underlying sorbent deactivation remains unclear at the atomic level and nanoscale due to past reliance on postmortem characterization methods with insufficient spatial and temporal resolution. Thus, elucidating the important CaCO3 decomposition reaction pathway requires direct observation by time‐resolved (sub‐)nanoscale methods. Here, chemical and structural dynamics during the decomposition of CaCO3 nanoparticles to nanoporous CaO particles comprising high‐surface‐area CaO nanocrystallites are examined. Comparing in situ transmission electron microscopy (TEM) and synchrotron X‐ray diffraction experiments gives key insights into the dynamics of nanoparticle calcination, involving anisotropic CaCO3 thermal distortion before conversion to thermally dilated energetically stable CaO crystallites. Time‐resolved TEM uncovered a novel CaO formation mechanism involving heterogeneous nucleation at extended CaCO3 defects followed by sweeping reaction front motion across the initial CaCO3 particle. These observations clarify longstanding, yet incomplete, reaction mechanisms and kinetic models lacking accurate information about (sub‐)nanoscale dynamics, while also demonstrating calcination of CaCO3 without sintering through rapid heating and precise temperature control.
A High‐Performance Phosphate Potentiometric Sensor Based on Cobalt Nanoparticles Electroplated on Hierarchically Porous Laser‐Induced Graphene
Authors: Chang Muxuan , Tang Rui , Zou Wenke , Xian Jieyu , Zhang Zhengwei , Liu Xingye , Qu Menglong , Zhang Cheng 
Published: April 2024

AbstractPhosphate is an important fertilizer in agriculture and electrochemical sensors based on cobalt (Co) are promising for measurement of phosphate. The deposition of Co onto conductive substrates to form a nano/microstructured Co layer with rich active sites is a typical strategy to improve detection performances. However, the widely used substrates show smooth surfaces, which cannot provide extra active sites. Herein, a high‐performance phosphate sensor is fabricated by generating Co nanoparticles (NPs) on a hierarchically porous laser‐induced graphene (LIG) matrix with a large surface area. Specifically, a Co layer is first electroplated on the LIG matrix. Nevertheless, the pores of LIG will be blocked by the dense Co layer so the performances of the fabricated LIG‐Co sensor exhibit limited enhancements. Therefore, a “nearly all etching (NAE)” technique is developed to transform the dense Co layer to dispersive Co NPs and re‐expose the pores of LIG, both increasing the active sites. Compared to the LIG‐Co sensor, the LIG‐Co NP sensor displays overall superiority. The response time, sensitivity, and linearity are enhanced from ≈60 to ≈10 s, from 0.012 to 0.069 V dec−1, and from 0.973 to 0.998, respectively. The LIG‐Co NP sensor also shows a decent anti‐interference capability.
Cationic Engineering Strategy to Achieve Controllable Room‐Temperature‐Phosphorescence in Hybrid Zinc Halides
Authors: Liu Yu‐Hang , Zhang Bing‐Lin , Wang Yu‐Jiao , Zhang Xiao‐Yang , Shang Yan‐Bing , Liu Tian‐Ci , Lei Xiao‐Wu , Chen Zhi‐Wei , Yue Cheng‐Yang 
Published: April 2024

AbstractDespite rapid progress and wide applications of room temperature phosphorescence (RTP) materials, it is still a great challenge to optimize the RTP activity through rational structural design at a molecular level. Herein, a successful cationic engineering strategy is demonstrated to modulate the crystal flexibility achieving controllable RTP in a new pair of metal halides [APML]ZnCl4 ([APML] = N‐(3‐Aminopropyl)morpholine) and [AEML]ZnCl4 ([AEML] = N‐(2‐Aminoethyl)morpholine). Both halides display blue fluorescence under 365 nm UV. Comparing with longer [APML]+, shorter [AEML]+ significantly enhances crystal rigidity and restrains non‐radiative scattering, boosting photoluminescence quantum yield (PLQY) from 18.89% to 22.41%. Synchronously, enhanced crystal rigidity significantly promotes the inter‐system crossing from singlet to triplet excited states. As a consequence, [AEML]ZnCl4 displays long‐lived green RTP property with millisecond scale lifetime in contrast to the blank RTP activity of [APML]ZnCl4. Comprehensive investigations demonstrate that the energy transfer between inorganic and organic components greatly changes the redistribution of singlet and triplet excited states, resulting in distinct phosphorescence activity. The different short‐lived blue fluorescence and long‐lived green phosphorescence provide a color‐time‐dual‐resolved luminescent tag with advanced applications in anti‐counterfeiting, etc. This work highlights a new structural engineering strategy to achieve controllable RTP affording a guide to rationally design RTP materials.
Chiral P,N,N‐Ligands for Asymmetric Hydrogenation
Authors: Liang Ding‐Hua , Hou Chuan‐Jin , Li Qi , Qin Hao , Li Ling , Hu Xiang‐Ping 
Published: April 2024

AbstractThe chiral P,N,N‐ligands represented a new type of tridentate ligand developed in recent years and displayed wide utilities in asymmetric catalysis. In the past decades, numerous chiral P,N,N‐ligands with ferrocene, phenethylamine and spiro backbones were synthesized by addition of an aminopyridine, imidazole or diamines coordinating group. These chiral tridentate P,N,N‐ligands showed excellent performance in the ruthenium, iridium, manganese, or cobalt‐catalyzed asymmetric hydrogenations. A wide range of substrates, including simple ketones, α‐halogenated ketones, α‐hydroxy ketones, α‐ or β‐amino keto‐ ones, α‐, γ‐, or δ‐keto acids, α‐ or β‐keto amides, β‐ or δ‐keto esters, α‐ or β‐enones, olefins, imines, quinolines and indoles, could be hydrogenated to afford the corresponding chiral products with high yields and enantioselectivities. In this review, progress on the asymmetric hydrogenation of C=O, C=N, C=C bonds with chiral tridentate P,N,N‐ligands was summarized.
Machine Learning Approach for Predicting the Hole Mobility of the Perovskite Solar Cells
Authors: Rashid Md Al Mamunur , Lee Seul , Kim Kwang Ho , Kim Jaeoh , Jeong Keunhong 
Published: April 2024

AbstractTraditional computational approaches such as Monte Carlo simulation, molecular dynamics, and density functional theory (DFT) have contributed to understanding the role of hole mobility in the development of suitable hole transporting materials (HTMs) for perovskite solar cell efficiency. However, these methods often involve significant computational expenses, thereby limiting the number of feasible studies and hindering the extraction of valuable structure−property guidelines for a rational design of novel HTMs. To address these challenges, this study proposes an ultrafast predictive model that balances prediction accuracy and time efficiency, a critical aspect for predicting the hole mobility of HTMs for perovskite optimization. The model, which leverages the Random Forest learning algorithm, enables comprehensive and rapid analysis of photovoltaic features taken from previous experiments/literature and processed with the RDKit Python library. Notably, recognizing the challenges associated with high correlation in the dataset, a method to improve the calculation of feature importance in random forests is applied. The results highlight bertz_ct, chi1, and logP as key predictive features of HTM performance. However, the model underscores the need to uncover additional predictive features based on structure–property relationships to predict the optimized hole mobility. This approach significantly accelerates the discovery process, outperforming prevalent statistical methods in the prediction of hole mobility and HTM performance. This research signifies a pivotal step toward cost‐effective, accelerated stability and efficiency of HTMs, with implications for the advancement of optoelectronic devices.
Building Haplotype‐Resolved 3D Genome Maps of Chicken Skeletal Muscle
Authors: Li Jing , Lin Yu , Li Diyan , He Mengnan , Kui Hua , Bai Jingyi , Chen Ziyu , Gou Yuwei , Zhang Jiaman , Wang Tao , Tang Qianzi , Kong Fanli , Jin Long , Li Mingzhou 
Published: April 2024

AbstractHaplotype‐resolved 3D chromatin architecture related to allelic differences in avian skeletal muscle development has not been addressed so far, although chicken husbandry for meat consumption has been prevalent feature of cultures on every continent for more than thousands of years. Here, high‐resolution Hi‐C diploid maps (1.2‐kb maximum resolution) are generated for skeletal muscle tissues in chicken across three developmental stages (embryonic day 15 to day 30 post‐hatching). The sequence features governing spatial arrangement of chromosomes and characterize homolog pairing in the nucleus, are identified. Multi‐scale characterization of chromatin reorganization between stages from myogenesis in the fetus to myofiber hypertrophy after hatching show concordant changes in transcriptional regulation by relevant signaling pathways. Further interrogation of parent‐of‐origin‐specific chromatin conformation supported that genomic imprinting is absent in birds. This study also reveals promoter‐enhancer interaction (PEI) differences between broiler and layer haplotypes in skeletal muscle development‐related genes are related to genetic variation between breeds, however, only a minority of breed‐specific variations likely contribute to phenotypic divergence in skeletal muscle potentially via allelic PEI rewiring. Beyond defining the haplotype‐specific 3D chromatin architecture in chicken, this study provides a rich resource for investigating allelic regulatory divergence among chicken breeds.
Catalytically Active Carbon for Oxygen Reduction Reaction in Energy Conversion: Recent Advances and Future Perspectives
Authors: Liu Shuling , Wang Ao , Liu Yanyan , Zhou Wenshu , Wen Hao , Zhang Huanhuan , Sun Kang , Li Shuqi , Zhou Jingjing , Wang Yongfeng , Jiang Jianchun , Li Baojun 
Published: April 2024

AbstractThe shortage and unevenness of fossil energy sources are affecting the development and progress of human civilization. The technology of efficiently converting material resources into energy for utilization and storage is attracting the attention of researchers. Environmentally friendly biomass materials are a treasure to drive the development of new‐generation energy sources. Electrochemical theory is used to efficiently convert the chemical energy of chemical substances into electrical energy. In recent years, significant progress has been made in the development of green and economical electrocatalysts for oxygen reduction reaction (ORR). Although many reviews have been reported around the application of biomass‐derived catalytically active carbon (CAC) catalysts in ORR, these reviews have only selected a single/partial topic (including synthesis and preparation of catalysts from different sources, structural optimization, or performance enhancement methods based on CAC catalysts, and application of biomass‐derived CACs) for discussion. There is no review that systematically addresses the latest progress in the synthesis, performance enhancement, and applications related to biomass‐derived CAC‐based oxygen reduction electrocatalysts synchronously. This review fills the gap by providing a timely and comprehensive review and summary from the following sections: the exposition of the basic catalytic principles of ORR, the summary of the chemical composition and structural properties of various types of biomass, the analysis of traditional and the latest popular biomass‐derived CAC synthesis methods and optimization strategies, and the summary of the practical applications of biomass‐derived CAC‐based oxidative reduction electrocatalysts. This review provides a comprehensive summary of the latest advances to provide research directions and design ideas for the development of catalyst synthesis/optimization and contributes to the industrialization of biomass‐derived CAC electrocatalysis and electric energy storage.
Targeting the MCP‐GPX4/HMGB1 Axis for Effectively Triggering Immunogenic Ferroptosis in Pancreatic Ductal Adenocarcinoma
Authors: Li Ge , Liao Chengyu , Chen Jiangzhi , Wang Zuwei , Zhu Shuncang , Lai Jianlin , Li Qiaowei , Chen Yinhao , Wu Dihan , Li Jianbo , Huang Yi , Tian Yifeng , Chen Yanling , Chen Shi 
Published: April 2024

AbstractInduction of ferroptosis can inhibit cancer cells in vitro, however, the role of ferroptosis in treatment in vivo is controversial. The immunosuppressive cells activated by the ferroptotic tumor cells can promote the growth of residual tumor cells, hindering the application of ferroptosis stimulation in tumor treatment. In this study, a new strategy is aimed to be identified for effectively triggering immunogenic ferroptosis in pancreatic ductal adenocarcinoma (PDAC) and simultaneously stimulating antitumor immune responses. Toward this, several molecular and biochemical experiments are performed using patient‐derived organoid models and a KPC mouse model (LSL‐KrasG12D/+, LSL‐Trp53R172H/+, Pdx‐1‐Cre). It is observed that the inhibition of macrophage‐capping protein (MCP) suppressed the ubiquitin fold modifier (UFM)ylation of pirin (PIR), a newly identified substrate of UFM1, thereby decreasing the transcription of GPX4, a marker of ferroptosis, and promoting the cytoplasmic transportation of HMGB1, a damage‐associated molecular pattern. GPX4 deficiency triggered ferroptosis, and the pre‐accumulated cytosolic HMGB1 is released rapidly. This altered release pattern of HMGB1 facilitated the pro‐inflammatory M1‐like polarization of macrophages. Thus, therapeutic inhibition of MCP yielded dual antitumor effects by stimulating ferroptosis and activating antitumor pro‐inflammatory M1‐like macrophages. The nanosystem developed for specifically silencing MCP is a promising tool for treating PDAC.
Integrative Single Cell Atlas Revealed Intratumoral Heterogeneity Generation from an Adaptive Epigenetic Cell State in Human Bladder Urothelial Carcinoma
Authors: Xiao Yu , Jin Wan , Qian Kaiyu , Ju Lingao , Wang Gang , Wu Kai , Cao Rui , Chang Luyuan , Xu Zilin , Luo Jun , Shan Liuying , Yu Fang , Chen Xintong , Liu Dongmei , Cao Hong , Wang Yejinpeng , Cao Xinyue , Zhou Wei , Cui Diansheng , Tian Ye , Ji Chundong , Luo Yongwen , Hong Xin , Chen Fangjin , Peng Minsheng , Zhang Yi , Wang Xinghuan 
Published: April 2024

AbstractIntratumor heterogeneity (ITH) of bladder cancer (BLCA) contributes to therapy resistance and immune evasion affecting clinical prognosis. The molecular and cellular mechanisms contributing to BLCA ITH generation remain elusive. It is found that a TM4SF1‐positive cancer subpopulation (TPCS) can generate ITH in BLCA, evidenced by integrative single cell atlas analysis. Extensive profiling of the epigenome and transcriptome of all stages of BLCA revealed their evolutionary trajectories. Distinct ancestor cells gave rise to low‐grade noninvasive and high‐grade invasive BLCA. Epigenome reprograming led to transcriptional heterogeneity in BLCA. During early oncogenesis, epithelial‐to‐mesenchymal transition generated TPCS. TPCS has stem‐cell‐like properties and exhibited transcriptional plasticity, priming the development of transcriptionally heterogeneous descendent cell lineages. Moreover, TPCS prevalence in tumor is associated with advanced stage cancer and poor prognosis. The results of this study suggested that bladder cancer interacts with its environment by acquiring a stem cell‐like epigenomic landscape, which might generate ITH without additional genetic diversification.
Inflammation‐Targeted Nanomedicines Alleviate Oxidative Stress and Reprogram Macrophages Polarization for Myocardial Infarction Treatment
Authors: Hu Danrong , Li Ran , Li Yicong , Wang Meng , Wang Lu , Wang Shiqi , Cheng Hongxin , Zhang Qing , Fu Chenying , Qian Zhiyong , Wei Quan 
Published: April 2024

AbstractMyocardial infarction (MI) is a critical global health challenge, with current treatments limited by the complex MI microenvironment, particularly the excessive oxidative stress and intense inflammatory responses that exacerbate cardiac dysfunction and MI progression. Herein, a mannan‐based nanomedicine, Que@MOF/Man, is developed to target the inflammatory infarcted heart and deliver the antioxidative and anti‐inflammatory agent quercetin (Que), thereby facilitating a beneficial myocardial microenvironment for cardiac repair. The presence of mannan on the nanoparticle surface enables selective internalization by macrophages rather than cardiomyocytes. Que@MOF/Man effectively neutralizes reactive oxygen species in macrophages to reduce oxidative stress and promote their differentiation into a reparative phenotype, reconciling the inflammatory response and enhancing cardiomyocyte survival through intercellular communication. Owing to the recruitment of macrophages into inflamed myocardium post‐MI, in vivo, administration of Que@MOF/Man in MI rats revealed the specific distribution into the injured myocardium compared to free Que. Furthermore, Que@MOF/Man exhibited favorable results in resolving inflammation and protecting cardiomyocytes, thereby preventing further myocardial remodeling and improving cardiac function in MI rats. These findings collectively validate the rational design of an inflammation‐targeted delivery strategy to mitigate oxidative stress and modulate the inflammation response in the injured heart, presenting a therapeutic avenue for MI treatment.
Reversible Constrained Dissociation and Reassembly of MXene Films
Authors: Zhang Xuefeng , Liu Xudong , Liu Qingqiang , Feng Yufa , Qiu Si , Wang Ting , Xu Huayu , Li Hao , Yin Liang , Kang Hui , Fan Zhimin 
Published: April 2024

AbstractEnabling materials to undergo reversible dynamic transformations akin to the behaviors of living organisms represents a critical challenge in the field of material assembly. The pursuit of such capabilities using conventional materials has largely been met with limited success. Herein, the discovery of reversible constrained dissociation and reconfiguration in MXene films, offering an effective solution to overcome this obstacle is reported. Specifically, MXene films permit rapid intercalation of water molecules between their distinctive layers, resulting in a significant expansion and exhibiting confined dissociation within constrained spaces. Meanwhile, the process of capillary compression driven by water evaporation reinstates the dissociated MXene film to its original compact state. Further, the adhesive properties emerging from the confined disassociation of MXene films can spontaneously induce fusion between separate films. Utilizing this attribute, complex structures of MXene films can be effortlessly foamed and interlayer porosity precisely controlled, using only water as the inducer. Additionally, a parallel phenomenon has been identified in graphene oxide films. This work not only provides fresh insights into the microscopic mechanisms of 2D materials such as MXene but also paves a transformative path for their macroscopic assembly applications in the future.