bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fine‐needle aspiration cytology of sarcomatoid renal cell carcinoma: A morphologic and immunocytochemical study of 15 cases
Authors: Auger Manon , Katz Ruth L. , Sella Avishay , Ordóñez Nelson G. , Lawrence David D. , Ro Jae Y. 
Published: February 2007

AbstractSarcomatoid renal cell carcinoma (SRCC), which accounts for 5% of all renal cell carcinomas (RCC), has a worse prognosis than conventional nonsarcomatoid RCC. making accurate diagnosis important. This study reports on the morphologic and immunocytochemical features of 15 cases of SRCC (9 primary tumors and 6 metastases) diagnosed by fine‐needle aspiration (FNA) biopsy. All but three cases showed a dimorphic cell population consisting of varying proportions of a high‐grade epithelial component, either clear or granular‐cell type and a spindle cell (sarcomatoid) component, of either fibrosarcomatous, malignant fibrous histiocytoma (MFH), or unclassified types. The sarcomatoid component in the biphasic and monophasic tumors stained positively for cytokeratin in 12 of 14 (85%) cases, for vimentin in 10 of 11 (91 %) cases, and for muscle‐specific action in 4 of 11 (36%) cases. Of note, the three cases that demonstrated a purely sarcomatoid morphology stained positively for cytokeratin. Unlike in studies performed on surgically resected specimens, neither the proportion of the sarcomatoid component nor the presence of necrosis had prognostic significance, the discrepancy most likely being related to the sampling. We conclude that SRCC, both primary and metastatic, can be accurately diagnosed by FNA when cytologic features are evaluated in conjunction with immunocytochemical findings.
Crystalloids in a cystic lesion of parotid salivary gland: Diagnosis by fine‐needle aspiration
Authors: Jayaram Gita , Khurana Nita , Basu Sabita 
Published: February 2007

AbstractCrystalline structures measuring < 800 pm in length, were found in smears of a fine‐needle aspirate of a cystic lesion in a parotid salivary gland. Numerous neutrophil leukocytes were also present, intimately mixed with the crystalloids. The lesion was re‐aspirated and the cyst completely evacuated, with no recurrence after a 6‐month follow up.
Sialadenosis of the parotid gland: Report of four cases diagnosed by fine‐needle aspiration cytology
Authors: Ascoli Valeria , Albedi Fiorella Malchiodi , De Blasiis Rosa , Nardi Francesco 
Published: February 2007

AbstractFour patients presented with a history of recurrent bilateral swellings of parotid glands. Fine‐needle aspiration (FNA) specimens showed highly cellular smears containing clusters of enlarged acini and numerous naked nuclei. A diagnosis consistent with sialadenosis was made considering the distinct morphologic appearance: micrometric measurements in all cases, in addition to histology and electron microscopy in two cases confirmed this hypothesis. A review of clinical histories revealed hormonal, nutritional and neurogenic disorders, which are known to be associated with sialadenosis. In the work‐up of salivary gland swellings, it is important to recognize cytologicaliy this underestimated entity, which does not necessarily require surgical treatment.
Fine‐needle aspiration cytodiagnosis of breast masses in pregnant and lactating women and its impact on management
Authors: Gupta Raj K. , McHutchison Andrew G. R. , Dowle Carl S , Simpson John S. 
Published: February 2007

AbstractWe reviewed our experience with 9.726 cases of fine‐needle aspiration cytology of the breast that were done from January 1983 to February 1992. During our review, we found that 214 aspirates had been submitted from pregnant and lactating women for the investigation of breast mass(es). Despite a variable clinical presentation and spectrum of cytologic findings, we considered the application of aspiration cytology in these women as useful as in the nonpregnant‐nonlactating women for management decision. A team approach between the clinician and cytopathologist was always maintained; with this approach, the false‐positive or ‐negative diagnoses were reduced to almost nil. In all cases in which the cytodiagnosis of carcinoma of breast was made, the findings corresponded with subsequent cell blocks from the aspirate and tissue examination. Benign lesions were diagnosed cytogically with minimal difficulty, and all aspirates that were less than optimal for cytodiagnosis were repeated to minimize the chance of missing an abnormality. All the benign lesions were followed throughout pregnancy, postpartum, and thereafter; if the mass persisted, the aspiration was repeated. With this protocol of follow‐up, the need for a customary liberal surgical biopsy was reduced to a minimum.
Diagnostic accuracy and clinical utility of fine‐needle aspiration cytology in the diagnosis of clinically primary bone lesions
Authors: Layfield Lester J. , Armstrong Kevin , Zaleski Sue , Eckardt Jeffrey 
Published: February 2007

AbstractOptimal treatment of primary bone sarcomas requires minimal disturbance of the tumor prior to preoperative radiation and chemotherapy. Currently, carefully planned incisional or cutting needle biopsies are the favored methods for procurement of specimens. Recently, fine‐needle aspiration has gained favor as the initial diagnostic procedure at some centers. We investigated the diagnostic accuracy and the effects of errors in diagnosis and of complications on the patient's course in a series of 101 patients presenting with lesions clinically believed to have arisen in bone. We found that 29% of aspirates were insufficient for the diagnosis; 41% of aspirates yielded a correct diagnosis that had a significant favorable impact on the patient's course, while 20% of aspirates gave a correct diagnosis that did not significantly influence therapy. In 7% of cases, the aspirates were associated with an incorrect diagnosis that negatively influenced therapy, and in an additional 3% of cases an incorrect diagnosis was obtained that had no impact on patient outcome. No complications were encountered in this series of patients.
Intranuclear inclusions in pleomorphic adenoma of salivary gland: A case report
Authors: Murty D. Anuradha , Sodhani Pushpa 
Published: February 2007

AbstractOn reviewing extensive literature on intranuclear cytoplasmic inclusions, one finds that the entity is almost synonymous with papillary carcinoma of the thyroid. But over the years, normal tissue aspirates as well as aspirates from many benign and malignant tumors have revealed the presence of these vacuoles. As more and more aspirations of cervical region are being done, it is becoming evident that intranuclear vacuoles are of decreasing specificity for papillary carcinoma of thyroid. This case is probably the first case report of intranuclear vacuoles from a pleomorphic adenoma of salivary gland and is being reported here for this unusual finding.
Fine‐needle aspiration cytology of primary large‐cell lymphoma of the mediastinum: Cytomorphologic Findings With Potential Pitfalls in Diagnosis
Authors: Silverman Jan F. , Raab Stephen S. , Park H. Kim , Katz Ruth L. 
Published: February 2007

AbstractWe report the fine‐needle aspiration (FNA) cytomorphologic features of six cases of primary mediastinal large‐cell lymphoma with sclerosis. The series consisted of three men and three women with a median age of 36 yr. All the patients presented with a large anterior or superior mediastinal mass with no evidence of peripheral lymphadenopathy or hepatosplenomegaly. Two of the cases showed typical findings of lymphoma, characterized by hypercellular specimens with numerous individually scattered markedly atypical lymphoid cells present, demonstrating nuclear irregularity with the presence of nucleoli and surrounding scant to slight amount of cytoplasm. Numerous lymphoglandular bodies were seen in the background. Both cases were correctly diagnosed as representing non‐Hodgkin's large‐cell lymphomas. Two other cases had slight cellularity with the presence of a few scattered atypical lymphoid cells. Although a definite diagnosis was not rendered in either case, the possibility of malignant lymphoma was considered. Two other cases consisted predominantly of microtissue fragments with some associated scattered individual atypical cells. Within the microtissue fragments, the cells were distorted with a tendency to elongate and spindle in a prominent fibrous matrix. Our experience demonstrates that FNA cytology of primary mediastinal diffuse large cell lymphoma with sclerosis can be challenging, with a potential for a false‐negative diagnosis due to limited cellularity secondary to the sclerosis or a misdiagnosis as a spindle cell neoplasm due to distortion of these cells by the fibrous matrix. To the best of our knowledge, we believe this is the first FNA series of primary mediastinal diffuse large cell lymphoma with sclerosis.
Ameloblastoma of the mandible: Diagnosis by fine‐needle aspiration cytology
Authors: Radhika S. , Nijhawan R. , Das A. , Dey P. 
Published: February 2007

AbstractThe fine needle aspiration cytologic findings of 3 cases of histologically proven ameloblastoma of the mandible are described. Tightly packed clusters of basaloid epithelial cells with palisading are a characteristic feature, Squamous differentiation was noted in all cases but was marked in one case seen as larger cells with central nucleus and abundant cytoplasm showing keratohyaline granules and whorls. A careful examination of the centrifuged sediment is important when fluid is aspirated as it may reveal a few characteristic clusters enabling a cytodiagnosis when supplemented by radiologic findings.
Fine‐needle aspiration biopsy of subcutaneous fat necrosis of the newborn
Authors: Walker William P. , Smith Richard J. H. , Cohen Michael B. 
Published: February 2007

AbstractThis report provides the first description of the fine‐needle aspiration biopsy findings in a case of subcutaneous fat necrosis of the newborn. While initial interpretation of the aspirate smears was suspicious for a neoplastic process, subsequent incisional biopsy confirmed the benign nature of the lesion. Review of the cytologic material revealed rare, negatively stained, needle‐shaped crystals within histiocytes and multinucleate giant cells. In the appropriate clinical setting, and given a mixture of lymphocytes, histiocytes, and multinucleate giant cells in the aspirate smears, we believe the finding of negatively stained needle‐shaped crystals can strongly suggest the diagnosis of subcutaneous fat necrosis of the newborn.
Fine‐needle aspiration diagnosis of intra‐thoracic and intra‐abdominal lesions: Review of experience in the pediatric age group
Authors: Das Dilip K. , Pant Chandra S. , Rath Bimbadhar , Parkash Suraj , James Thankamma , Sodhani Pushpa 
Published: February 2007

AbstractReview of fine‐needle aspiration (FNA) smears from 121 pediatric patients with intra‐thoracic and intra‐abdominal lesions revealed 42 (34.7%) cases of neoplasms, 35 (28.9%) cases of tuberculosis, 12 (9,9%) cases of non‐tuberculous inflammations, 4 (3.3%) cases of benign cystic lesions, and 28 (23.1%) inadequate/inconclusive cases. The age of the patients ranged from 20 days to 18 yr. Ultrasound and/or CT study done in 105 cases localized the lesions in following common sites: lungs (19 cases), mediastinum (22 cases), liver (14 cases), intestines (11 cases), and lymph nodes (17 cases). The neoplastic lesions consisted of 39 malignant, one suspicious, and two benign neoplasms. Among the neoplasms, the small round cell tumors were the most frequent (27 cases), followed by germ cell tumors (eight cases) and miscellaneous neoplasms (seven cases). The common small round cell tumors were non‐Hodgkins lymphoma (eight cases), hepatoblastoma (seven cases), neuroblastoma (five cases), and nephroblastoma (three cases). A combined clinical, imaging, and FNA cytology approach was found to be useful in arriving at a tissue diagnosis.
Preliminary evaluation of cyto‐rich: An improved automated cytology preparation
Authors: Geyer James W. , Hancock Frank , Carrico Charles , Kirkpatrick Marilyn , Linder James 
Published: February 2007

AbstractA new cervical cytology monolayer preparation system called Cyto‐Rich was evaluated. Using samples from 557 patients, Cyto‐Rich monolayers were compared to matched conventional smears. After conventional smears were prepared and spray fixed, residual exfoliated cells were transferred to preservative fluid. The cell suspensions were gently disaggregated and the epithelial component enriched with gradient centrifugal sedimentation. The batched samples were then placed on the Cyto‐Rich work station where slides are automatically prepared and stained. The results demonstrate that Cyto‐Rich prepared monolayers are vastly superior to the conventional smears for cell presentation. While the study showed 99% overall concordance, Cyto‐Rich improved the detection of low‐grade cervical intraepithelial lesions.
Fine‐needle aspiration cytology of idiopathic pancreatic islet cell adenosis
Authors: Gala Indira , Atkinson Barbara F. , Nicosia Roberto F. , Hermann George A. 
Published: February 2007

AbstractA 68‐yr‐old woman was hospitalized because of abdominal pain, an enlarged pancreatic head by CT, and a questionable 4‐cm mass in the liver. Fine‐needle aspiration (FNA) of the pancreatic head disclosed a highly cellular specimen consisting of clusters of cytologically bland, monotonous, small nuclei and variable but generally sparse cytoplasm. Because of the differentiated monomorphic character of the cell clusters, the postaspiration differential cytopathologic diagnosis included islet cell tumor, acinic cell tumor, carcinoid. lymphoma, and well differentiated ductal adenocarcinoma. Pancreaticoduodenectomy and hepatic biopsy yielded a grossly normal pancreas and a cirrhotic liver. Histologic examination of the pancreas revealed a spotty but extensive spectrum of islet changes ranging from normal to bland hyperplasia, nesidioblastosis, microadenosis, and neuroendocrine microadenomas, all appearing in a light and electron microscopic context of an otherwise normal pancreas. This case highlights the differential diagnostic ambiguities presented by a continuum of pancreatic islet cell proliferations, especially among patients in whom there are no known predisposing factors for such diffuse preneoplastic or neoplastic changes.
Fine‐needle aspiration of intra‐abdominal desmoplastic small cell tumor
Authors: Caraway Nancy P. , Fanning Christina V. , Amato Robert J. , Ordóñez Nelson G. , Katz Ruth L. 
Published: February 2007

AbstractThe cytologic features of four cases of histologically confirmed intra‐abdominal desmoplastic small cell tumor (DSCT) that occurred in males between 18‐27 yr of age are presented. Smears showed small cells with scant cytoplasm which were primarily arranged in loosely cohesive clusters. Nuclei were oval to round with evenly distributed, finely granular chromatin and inconspicuous nucleoli. As is typical of DSCT, the cells strongly expressed keratin and desmin in all cases. In the one case studied by electron microscopy, it was demonstrated that the cells were joined by small junctions and contained paranuclear aggregates of intermediate filaments. The absence of the characteristic desmoplastic stroma in DSCT aspirates and the nonspecific cytologic features of this small round‐cell tumor (SRCT) made cytologic interpretation difficult. Cytopathologists should be aware of this entity so that DSCT is included in the differential diagnosis of SRCTs that occur in intra‐abdominal sites. A panel of markers that includes keratin and desmin should be used to assist in the identification of DSCT.
Preoperative cytodiagnosis of primitive carcinoid tumor of the wirsung duct: A case report with immunocytochemical study
Authors: dei Tos Angelo P. , Laurino Licia , de Boni Michele , Doglioni Claudio 
Published: February 2007

AbstractA case of primitive carcinoid tumor of the Wirsung duct detected by fiberoptic guided brushing cytology is reported. The authors describe the main cytomorphologic characteristics and underline the role of immunocytochemistry in helping to reach a reliable preoperative diagnosis.
Incidence and distribution of opportunistic lung infections in aids patients related to intravenous drug use: A study of bronchoalveolar lavage cytology by the diff‐quik stain
Authors: Kyriazis Andreas P. , Kyriazis Aikaterini A. 
Published: February 2007

AbstractThe present study was undertaken in order to determine the incidence and distribution of opportunistic lung infections in patients with acquired immunodeficiency syndrome related to intravenous drug use. One hundred ninety seven patients of both sexes were investigated. Based on bronchoalveolar lavage cytology, a total of 156 (79%) patients were found to harbor opportunistic lung infections by the Diff‐Quik staining procedure. Seventy‐nine percent of the males and 80% of the females were positive. Pneumocystis carinii was the most common of the opportunistic infections accounting for 83% of the positive cases. Cryptococcus. Candida sp., and Aspergillus sp. were also identified in a small number of patients. Cytomegalovirus was not detected in any of the cases under study. There were no sex‐related differences in the distribution of the various infectious agents, males and females being equally affected.
Fine‐needle aspiration cytology of silicone granulomas in the augmented breast
Authors: Dodd Leslie G. , Sneige Nour , Reece Gregory P. , Fornage Bruno 
Published: February 2007

AbstractWe studied 12 aspirates from 10 patients who underwent diagnostic fine‐needle aspiration cytology (FNAC) of an augmented or reconstructed breast. Six patients were augmented with silicone gel‐filled implants and four patients had silicone liquid injections. FNAC indications included a painful or suspicious mass. Excisional biopsy was performed in six cases after FNAC. The findings of eight cases included modestly cellular smears composed of loosely cohesive histiocytes containing vacuoles of various sizes. Multinucleated foreign body giant cells, fragments of dense, amorphous fibrous tissue, and fibroblast nuclei stripped of cytoplasm were also present Two patients showed a mixture of inflammatory cells characteristic of intramammary lymph nodes or lymphoid aggregates. We conclude that silicone granulomas of the breast show a characteristic set of findings on FNAC which enable a cytopathologist to render a specific diagnosis given an appropriate history of breast augmentation. Diagn Cytopathol 1993;9:498‐502. © 1993 Wiley‐Liss, Inc.
Evaluation of a method for cryogenic storage of cytological specimens
Authors: Shield P. W. , Halford J. A. , Goulden R. 
Published: February 2007

AbstractA technique for long‐term storage of cytological specimens at — 70°C was evaluated with a range of nongynaecological cytology specimens. The effects of frozen storage on the cellularity, morphology, ultrastructure, and reactivity to cytochemical and immunochemical stains were investigated. These parameters were compared in preparations made from specimens processed conventionally and after frozen storage.No significant deterioration in the quality of subsequent preparations was apparent after storage. The method is technically simple and has proven successful for storing a range of specimens, including serous effusions, urine samples, and fine‐needle aspirates. This technique allows storage of material until initial microscopic evaluation is complete. If required, the relevant adjuvant procedure, such as cell blocking, may then be carried out using the stored material. Wastage of cytological material on unnecessary preparations is minimised, and material may be stored over years for research or confirmation procedures.
Intraoperative cytology in breast cancer diagnosis: Comparison between cytologic and frozen section techniques
Authors: De Rosa G. , Boschi R. , Boscaino A. , Petrella G. , Vetrani A. , Palombini L. , Pettinato G. 
Published: February 2007

AbstractThe diagnostic accuracy of frozen section (FS) examination and intraoperative cytology (IOC) has been compared in two different series of breast biopsies in which only one of the two methods has been used. The intraoperative results have been compared with the final histological diagnoses. Five‐hundred‐ten cases have been investigated by using FS only, and 407 by means of IOC. The two series were comparable because they included the same pathologies; moreover we have subdivided each series into four groups of pathologies to better evaluate the diagnostic accuracy of two methods.The total diagnostic accuracy of FS has been 93.13% vs. 95.‐33% of IOC The value of diagnostic accuracy of FS and IOC in the four sub‐groups substantially overlapped; there was only a little difference in the group of “various lesions” in which the diagnostic accuracy of IOC was higher. No false positive has been observed in IOC. FS have produced one false positive (0.19%), whereas false negatives have amounted to 1.77% for IOC and to 1.72% for FS. Deferred diagnoses have been 2.95% in IOC and 4.90% in FS examination. For both methods according to Galen and Gambino the following values have been calculated: sensitivity, specificity, efficiency, and predictive value. By comparing the data, the value of the cytological examination in the intraoperative diagnoses results is evident mainly when the latter is coupled with the gross observation.Causes of diagnostic errors clearly overlap both in IOC and in FS: (1) lesions with a fibroadenomatous appearance can involve an overdiagnosis or an underdiagnosis; (2) low‐grade lesions like tubular carcinomas or in situ lobular carcinomas can be interpreted as benign; (3) the differential diagnosis of intraductal lesions may be very difficult, and a conservative approach is the best choice; and (4) infiltrating lobular carcinoma may be neglected both in FS and IOC.The few disadvantages of the cytologic method are offset by its low cost, the wider sampling, the possibility of sparing tissue for further investigations (such as steroid receptors, cellular kinetic, electron microscopy, and other biological studies) proved more useful in prognostic evaluation of breast cancer.
Cytodiagnosis of pseudomyxoma peritonei in cases suspected of ovarian tumours
Authors: Gupta Raj K. , Naran Sarla 
Published: February 2007

AbstractThe cytologic features in four cases of pseudomyxoma peritonei are described in ascitic fluid specimens which were received from female patients suspected of ovarian masses. The findings in the fluid included cells of mesothelial origin and spindle‐shaped fibroblasts with a significant amount of background mucin. This was confirmed by mucicarmine and Alcian blue stains. A cytologic diagnosis of pseudomyxoma peritonei was possible in all four cases. The above findings were further substantiated since mucinous ovarian neoplasms were found in all the cases.
Medulloblastoma metastatic to breast, diagnosed by fine‐needle aspiration biopsy
Authors: Baliga Mithra , Holmquist Nelson D. , Espinoza Carmen G. 
Published: February 2007

AbstractThe extracranial spread of a primary intracranial tumor is an infrequent occurrence. The most common metastatic sites in order of frequency are bone, lymph nodes, and soft tissue. Analysis of the literature uncovered only two case reports of medulloblastoma that had metastasized to the breast. Both of these cases were diagnosed by open surgical biopsies. We present a case of medullo‐blastoma metastatic to the breast which was diagnosed by fineneedle aspiration biopsy. This diagnosis was subsequently confirmed by a tru‐cut surgical biopsy and was further supported by immunohistochemical studies. © 1994 Wiley‐Liss, Inc.
Fine‐needle aspiration diagnosis of a vulvar papillary hidradenoma: A case report
Authors: Rollins Susan D. 
Published: February 2007

AbstractPapillary hidradenoma of the vulva, also know as hidradenoma papilliferum, is an uncommon lesion which occurs in post‐pubertal women. Review of the literature yielded no fine‐needle aspiration reports of the cytologic features of vulvar papillary hidradenoma. © 1994 Wiley‐Liss, Inc.