bluuebunny/crossref_metadata_2025_split huggingface dataset:
Democracy's Fatal Flaw: Anonymity and the Normalization of Offence in John Dunton's Epistolary Periodicals
Authors: Berry Helen 
Published: March 2024

AbstractEpistolary periodicals associated with English coffee house culture have often been associated with Jürgen Habermas' model for the rise of the ‘bourgeois public sphere’. Habermas proposed this ultimately gave rise to the free articulation of public opinion and the emergence of democratic values. Written at a time of socio‐political upheaval, John Dunton's serial publications relied upon anonymous authorship, particularly his most famous periodical, the Athenian Mercury (1691–97), which pioneered the question‐and‐answer format and gave rise to many imitations. In the present era, we are witnessing democracy imperilled by the proliferation of AI‐driven ‘fake news’. This paper proposes that the origins of this phenomenon may be found in epistolary periodicals which normalized giving and receiving offence in print. The pernicious quality of anonymous print, free from personal accountability or consequences, embedded from its inception a fatal flaw in the project of constituting a democratic public sphere.
Functional analyses of bacterial genomes found in Symbiodiniaceae genome assemblies
Authors: Shoguchi Eiichi , Kawachi Masanobu , Shinzato Chuya , Beedessee Girish 
Published: March 2024

AbstractBacterial–algal interactions strongly influence marine ecosystems. Bacterial communities in cultured dinoflagellates of the family Symbiodiniaceae have been characterized by metagenomics. However, little is known about whole‐genome analysis of marine bacteria associated with these dinoflagellates. We performed in silico analysis of four bacterial genomes from cultures of four dinoflagellates of the genera Symbiodinium, Breviolum, Cladocopium and Durusdinium. Comparative analysis showed that the former three contain the alphaproteobacterial family Parvibaculaceae and that the Durusdinium culture includes the family Sphingomonadaceae. There were no large genomic reductions in the alphaproteobacteria with genome sizes of 2.9–3.9 Mb, implying they are not obligate intracellular bacteria. Genomic annotations of three Parvibaculaceae detected the gene for diacetylchitobiose deacetylase (Dac), which may be involved in the degradation of dinoflagellate cell surfaces. They also had metabolic genes for dissimilatory nitrate reduction to ammonium (DNRA) in the nitrogen (N) cycle and cobalamin (vitamin B12) biosynthetic genes in the salvage pathway. Those three characters were not found in the Sphingomonadaceae genome. Predicted biosynthetic gene clusters for secondary metabolites indicated that the Parvibaculaceae likely produce the same secondary metabolites. Our study suggests that the Parvibaculaceae is a major resident of Symbiodiniaceae cultures with antibiotics.
Taxonomic patterns of host plants and its impact on honey properties by two sympatric Afrotropical stingless bee species in Zanzibar (Tanzania)
Authors: Ndungu Nelly , Noiset Pierre , Chege Mary , Waweru Jacqueline Wahura , Sharifu Nassor , Vereecken Nicolas J. , Kiatoko Nkoba 
Published: March 2024

AbstractStingless bees are important pollinators and producers of honey used in folk medicine. We investigate the nectar sources for two Afrotropical stingless bee species, Hypotrigona araujoi and Meliponula ferruginea. Pollen was extracted and processed using next‐generation sequencing (NGS) methods, DNA metabarcoding. Results show that stingless bees visited 32 plant genera. Wild plants were the major nectar sources for the two stingless bees' species. The diversity of plants visited and honey physical–chemical characteristics differed between the two bee species, suggesting that they use comparable spectra of host plants. This information should help prioritise the conservation of identified forage plants.
Modeling perceived parental attitudes and mental well‐being in Chinese young LGBTQ+ individuals: Investigation of weekly diary data using dynamic network analysis
Authors: Wang Yuanyuan , Ma Zhihao , Wang Yinzhe , Liu Kunxu , Li Jiaqi 
Published: March 2024

AbstractExisting literature has reported negative parental attitudes toward LGBTQ+ individuals associated with their LGBTQ+ identity concealment and mental well‐being. However, limited research has explored the dynamic network changes using intensive, repeated weekly diary data. This study aimed to model the associations between perceived parental attitude, anxiety, depression, and LGBTQ+ individuals' identity concealment within dynamic network analysis (DNA); 103 LGBTQ+ youth participated in the study. Participants' perceived parental attitudes toward LGBTQ+ identity and LGBTQ+ identity concealment, depression (by the 9‐item Patient Health Questionnaire), and anxiety (by the 7‐item Generalized Anxiety Disorder Questionnaire) were measured. Each was assessed four times at 1‐week intervals for four consecutive weeks. The graphical vector autoregression explored the DNA of the internal relationships among perceived parental attitudes, identity concealment, depression, and anxiety. Findings in the between‐subjects network revealed that poor perceived parental attitudes toward sexual and gender minorities were positively associated with depression, anxiety, and identity concealment. The contemporaneous network showed that the “expression” (one's identity concealment) was the direct trigger of “suicide” (one's depressive symptom), indicating depression was initiated earlier and subsequently exacerbated a sequence of other psychiatric reactions. The temporal network indicated that only parents' “general attitude” reduced participants' concealment (“self‐disclosure”), which simultaneously stimulated mental benefits.
Development and validation of a brain fog scale for coeliac disease
Authors: Knowles Simon R. , Apputhurai Pragalathan , Tye‐Din Jason A. 
Published: March 2024

SummaryBackgroundBrain fog is a subjective cognitive impairment commonly reported in coeliac disease. A standardised tool to define and assess it is an important unmet need.AimsTo develop a patient‐informed tool to assess brain fog in coeliac disease to support clinical care, research and drug development.MethodsA pilot online study defined patient descriptors of brain fog. A second study evaluated the factor structure and performance of the scale across two‐time points (‘Now’ and in the ‘Past week’). One month later, participants were invited to repeat the study with two online cognitive processing tests, the Stroop task and the trail making test.ResultsAmong adults with treated coeliac disease, 37 (91.9% F) participated in the pilot study and 510 (88.8% F) in the second study of whom 99 repeated the study 1 month later with 51 completing cognitive testing. The most common brain fog descriptors were ‘difficulty focusing’, ‘difficulty thinking’ and ‘difficulty finding the right words and communicating’. The 12‐item scale reflects ‘cognitive impairment’ and ‘somatic and affective experience’ and demonstrates strong psychometric properties. It tracked with patients report of brain fog being present or absent across two‐time points. It did not significantly correlate with the cognitive tests.ConclusionThe brain fog assessment and severity scale is the first patient‐informed clinical outcomes assessment tool measuring brain fog in coeliac disease. It is brief and validated for two time‐based formats. Further research coupling it with biomarker discovery is needed to confirm its validity as a predictor of cognitive performance.
Cooperative school climates are positively linked with socio‐emotional skills: A Cross‐National Study
Authors: Wang Faming , King Ronnel B. , Zeng Lily Min 
Published: March 2024

AbstractBackgroundSocio‐emotional skills are critical to life outcomes such as achievement, well‐being and job success. However, existing research has mostly focused on the consequences of socio‐emotional skills, with less attention devoted to the role of school climate in the deployment of these skills.AimsThis study investigated the role of school climate in socio‐emotional skills. More specifically, we investigated whether cooperative or competitive school climates are associated with students' socio‐emotional skills.SampleOur study utilized data from the OECD Survey on Social and Emotional Skills, collected from 10 cities across nine countries. Participants were 60,985 students, including 31,187 10‐year‐olds (49.70% females) and 29,798 15‐year‐olds (51.6% females).MethodsWe conducted multilevel structural equation modelling to test whether cooperative and competitive climates were associated with socio‐emotional skills. These skills include five broad domain skills and 15 more specific skills: task performance (self‐control, responsibility and persistence), emotion regulation (stress resistance, emotional control and optimism), collaboration (empathy, trust and cooperation), open‐mindedness (tolerance, curiosity and creativity) and engaging with others (sociability, assertiveness and energy).ResultsOur findings indicated a positive relationship between a cooperative climate and socio‐emotional skills. In contrast, the relationship between a competitive climate and socio‐emotional skills was primarily negative.ConclusionThis study highlights the contrasting roles of cooperative and competitive climates in students' socio‐emotional skills.
CXCR4WHIMsyndrome is a cancer predisposition condition for virus‐induced malignancies
Authors: Moulin Clémentine , Beaupain Blandine , Suarez Felipe , Bertrand Yves , Beaussant Sarah Cohen , Fischer Alain , Durin Julie , Ranta Dana , Espéli Marion , Bachelerie Françoise , Bellanné‐Chantelot Christine , Molina Thierry , Emile Jean François , Balabanian Karl , Deback Claire , Donadieu Jean 
Published: March 2024

SummaryWarts, hypogammaglobulinaemia, infections and myelokathexis syndrome (WHIMS) is a rare combined primary immunodeficiency caused by the gain of function of the CXCR4 chemokine receptor. We present the prevalence of cancer in WHIMS patients based on data from the French Severe Chronic Neutropenia Registry and an exhaustive literature review. The median follow‐up of the 14 WHIMS ‘patients was 28.5 years. A central review and viral evaluation of pathological samples were organized, and we conducted a thorough literature review to identify all reports of WHIMS cases. Six French patients were diagnosed with cancer at a median age of 37.6 years. The 40‐year risk of malignancy was 39% (95% confidence interval [CI]: 6%–74%). We observed two human papillomavirus (HPV)‐induced vulvar carcinomas, three lymphomas (two Epstein–Barr virus [EBV]‐related) and one basal cell carcinoma. Among the 155 WHIMS cases from the literature, 22 cancers were reported in 16 patients, with an overall cancer 40‐year risk of 23% (95% CI: 13%–39%). Malignancies included EBV‐associated lymphoproliferative disorders and HPV‐positive genital and anal cancers as in the French cohort. Worldwide, nine cases of malignancy were associated with HPV and four with EBV. Immunocompromised WHIMS patients appear to be particularly susceptible to developing early malignancy, mainly HPV‐induced carcinomas, followed by EBV‐related lymphomas.
Molecular characterization of diffuse large B‐cell lymphomas associated with hepatitis C virus infection
Authors: Sciarra Roberta , Merli Michele , Cristinelli Caterina , Lucioni Marco , Zibellini Silvia , Riboni Roberta , Furlan Daniela , Uccella Silvia , Zerbi Caterina , Bianchi Benedetta , Gotti Manuel , Ferretti Virginia Valeria , Varraso Chiara , Fraticelli Sara , Lazic Tanja , Defrancesco Irene , Mora Barbara , Libera Laura , Mazzacane Alessandro , Carpi Federico , Berliner Martha , Neri Giuseppe , Rizzo Ettore , De Paoli Federica , Sessa Fausto , Passamonti Francesco , Paulli Marco , Arcaini Luca 
Published: March 2024

SummaryHepatitis C virus (HCV)‐associated diffuse large B‐cell lymphoma (DLBCL) displays peculiar clinicopathological characteristics, but its molecular landscape is not fully elucidated. In this study, we investigated the clinicopathological and molecular features of 54 patients with HCV‐associated DLBCL. The median age was 71 years. An underlying marginal zone lymphoma component was detected in 14.8% of cases. FISH analysis showed rearrangements involving BCL6 in 50.9% of cases, MYC in 11.3% and BCL2 in 3.7%. Lymph2Cx‐based assay was successful in 38 cases, recognizing 16 cases (42.1%) as ABC and 16 cases as GCB subtypes, while six resulted unclassified. ABC cases exhibited a higher lymphoma‐related mortality (LRM). Next‐generation sequencing analysis showed mutations in 158/184 evaluated genes. The most frequently mutated genes were KMT2D (42.6%), SETD1B (33.3%), RERE (29.4%), FAS and PIM1 (27.8%) and TBL1XR1 (25.9%). A mutation in the NOTCH pathway was detected in 25.9% of cases and was associated with worst LRM. Cluster analysis by LymphGen classified 29/54 cases within definite groups, including BN2 in 14 (48.2%), ST2 in seven (24.2%) and MCD and EZB in four each (13.8%). Overall, these results indicate a preferential marginal zone origin for a consistent subgroup of HCV‐associated DLBCL cases and suggest potential implications for molecularly targeted therapies.
Homeless youth with intellectual disabilities: Precarious lives and health inequalities
Authors: Fudge Schormans Ann , Baker Collins Stephanie , Allan Heather , Allen D. O'Neil , Gray Nathan 
Published: March 2024

AbstractBackgroundYouth with intellectual disabilities experiencing homelessness are invisible within multiple service sectors. We know little about their experiences of homelessness, or the impacts of such on the social and physical health and well‐being.MethodsWe used quantitative and qualitative methods to measure prevalence and learn from key informants and homeless youth with intellectual disabilities about factors leading to and sustaining homelessness, and the implications of such on their social, physical, and mental health and well‐being. The project involved seven co‐researchers with intellectual disabilities and experience of youth homelessness in research design, data collection, analysis, and dissemination. We created Forum Theatre scenes that creatively represent the findings of the project. In this paper we share one of those scenes, as well as the recommendations three co‐researchers with intellectual disabilities have for improving support to homeless youth with intellectual disabilities.FindingsLack of awareness of and about homeless youth with intellectual disabilities, combined with siloed ways of working by involved sectors, results in significant disadvantage and health inequities for youth. Also revealed was the likelihood this would continue given existing obstacles to accessing appropriate housing and supports to exit homelessness.ConclusionServices providers, policy makers and representatives of the involved sectors need to recognize and acknowledge homeless youth with intellectual disabilities and take responsibility for learning and working together to develop integrated and responsive approaches to effectively supporting them.
Plant phylogenetic diversity influences arthropod communities in tropical forest restoration plots
Authors: Ugalde Faride , Santos‐Gally Rocío , Pérez‐Ishiwara Rubén , Gálvez‐Reyes Nancy , Wegier Ana , Boege Karina 
Published: March 2024

AbstractConsideration of plant phylogenetic diversity in ecological restoration carries substantial potential, as communities with a greater diversity of lineages with older evolutionary histories can increase the diversity of niches and thus are likely to recover larger species networks than communities clustered in specific clades with reduced variation in functional traits. In this study, we experimentally assessed how arthropod communities were affected by the phylogenetic diversity of a set of tropical tree species. We established 12 experimental restoration plots with either high or low plant phylogenetic diversity while maintaining constant the number of plant species. After 1 and 3 years, arthropods with different feeding habits (herbivores, predators, pollinators, and detritivores) were collected and identified as morphospecies or operational taxonomic units using metabarcoding techniques. We provide insights on the influence of plant phylogenetic diversity on arthropod abundance and species diversity, particularly among predator, pollinator, and detritivore common and dominant species, which increased with plant phylogenetic diversity. The trend, however, was the opposite for the diversity of herbivore common and dominant species, which decreased as plant phylogenetic diversity increased. These findings highlight the importance of considering plant species richness when designing restoration strategies, but also their evolutionary histories, as the same number of plant species can produce different outcomes for higher trophic levels, as a function of their phylogenetic relationships.Abstract in Spanish is available with online material.
Design, synthesis, in silico molecular docking, and ADMET studies of quinoxaline‐isoxazole‐piperazine conjugates as EGFR‐targeting agents
Authors: Ali Mohammad Imtiyaz , Thirukovela Narasimha Swamy , Kumar Gajjela Bharath , Dasari Gouthami , Badithapuram Vinitha , Manchal Ravinder , Bandari Srinivas 
Published: March 2024

AbstractIn this paper, we report the synthesis of quinoxaline‐isoxazole‐piperazine conjugates. The anticancer activity was evaluated against three human cancer cell lines, including MCF‐7 (breast), HepG‐2 (liver), and HCT‐116 (colorectal). The outcomes of the tested compounds 5d, 5e, and 5f have shown more potent activity when compared to the standard drug erlotinib. In a cell survivability test (MCF‐10A), three potent compounds (5d, 5e, and 5f) were evaluated against the normal breast cell line, although neither of them displayed any significant cytotoxicity with IC50 values greater than 84 μM. Furthermore, the compounds 5d, 5e, and 5f were tested for tyrosine kinase EGFR inhibitory action using erlotinib as the reference drug and compound 5e was shown to be more potent in inhibiting the tyrosine kinase EGFR than sorafenib. In addition to this, molecular docking studies of compounds 5d, 5e, and 5f demonstrated that these compounds had more EGFR‐binding interactions. The potent compounds 5d, 5e, and 5f were subjected to in silico pharmacokinetic assessment by SWISS, ADME, and pkCSM. While the compounds 5d, 5e, and 5f followed Lipinski, Veber, Egan, and Muegge rules without any deviation.
Natural history and biomarkers of KCNV2‐associated retinopathy
Authors: Sakti Dhimas H. , Cornish Elisa E. , Ali Haipha , Retsas Stephanie , Raza Marium , Saakova Nonna , Carvalho Livia S. , Nash Benjamin M. , Jamieson Robyn V. , Grigg John R. 
Published: March 2024

AbstractBackgroundKCNV2‐associated retinopathy is an autosomal recessive inherited retinal disease classically named cone dystrophy with supernormal rod response (CDSRR). This study aims to identify the best biomarker for evaluating the condition.MethodsA retrospective review of eight patients from seven families with genetically confirmed KCNV2‐associated retinopathy was performed. The best corrected visual acuity (BCVA), full‐field electroretinogram (ffERG), pattern ERG (pERG), fundus imaging: retinal photograph and fundus autofluorescence (FAF), and optical coherence tomography (OCT) were analysed.ResultsThere was a disproportionate increase in b‐wave amplitude with a relatively small light intensity increase, especially between the two dimmest stimuli of DA 0.002 and 0.01 (−2.7 and −2.0 log cd.s/m2). The a‐wave amplitude was normal. The a‐wave peak time was delayed in all stimuli. The b‐wave peak time was delayed compared to normal, but the gap tightened as intensity increased. The b:a wave ratio was above or at the upper limit for the reference values. FAF bull's eye maculopathy pattern was prominent and variable foveal disruption on OCT was apparent in all patients. Legal blindness was reached before the age of 25.ConclusionsWe identified three potential electrophysiology biomarkers to assist in evaluating future therapies: the disproportionate b‐wave amplitude jump, delayed a‐wave and b‐wave peak time, and the higher than normal b:a wave ratio. Any of these biomarkers found with photoreceptor ellipsoid zone foveal‐perifoveal disruption should prompt consideration for KCNV2 retinopathy. The BCVA natural history data suggests the probable optimum therapeutic window in the first three decades of life.
Improving well‐being and reducing deforestation in Indonesia's protected areas
Authors: Morgans Courtney Leslie , Jago Sophie , Andayani Noviar , Linkie Matthew , Lo Michaela G. Y. , Mumbunan Sonny , St. John Freya A. V. , Supriatna Jatna , Voigt Maria , Winarni Nurul L. , Santika Truly , Struebig Matthew J. 
Published: March 2024

AbstractProtected areas (PAs) are central to sustainability targets, yet few evaluations explore outcomes for both conservation and development, or the trade‐offs involved. We applied counterfactual analyses to assess the extent to which PAs maintained forest cover and influenced well‐being across >31,000 villages in Sumatra and Kalimantan, Indonesia. We examined multidimensional aspects of well‐being, tracking education, health, living standards, infrastructure, environment, and social cohesion in treatment and control villages between 2005 and 2018. Overall, PAs were effective at maintaining forest cover compared to matched controls and were not detrimental to well‐being. However, impacts were highly heterogeneous, varying by island and strictness of protection. While health, living standards, and infrastructure aspects of well‐being improved, education access, environmental conditions, and social cohesion declined. Our analysis reveals the contexts through which individual PAs succeed or fail in delivering multiple benefits and provides insights into where further on‐ground support is needed to achieve conservation and development objectives.
Proposing a framework to quantify the potential impact of pharmacokinetic drug–drug interactions caused by a new drug candidate by using real world data about the target patient population
Authors: Dagenais Simon , Lee Christine , Cronenberger Carol , Wang Ellen , Sahasrabudhe Vaishali 
Published: March 2024

AbstractDrug development teams must evaluate the risk/benefit profile of new drug candidates that perpetrate drug–drug interactions (DDIs). Real‐world data (RWD) can inform this decision. The purpose of this study was to develop a predicted impact score for DDIs perpetrated by three hypothetical drug candidates via CYP3A, CYP2D6, or CYP2C9 in type 2 diabetes mellitus (T2DM), obesity, or migraine. Optum Market Clarity was analyzed to estimate use of CYP3A, CYP2D6, or CYP2C9 substrates classified in the University of Washington Drug Interaction Database as moderate sensitive, sensitive, narrow therapeutic index, or QT prolongation. Scoring was based on prevalence of exposure to victim substrates and characteristics (age, polypharmacy, duration of exposure, and number of prescribers) of those exposed. The study population of 14,163,271 adults included 1,579,054 with T2DM, 3,117,753 with obesity, and 410,436 with migraine. For T2DM, 71.3% used CYP3A substrates, 44.3% used CYP2D6 substrates, and 44.3% used CYP2C9 substrates. For obesity, 57.1% used CYP3A substrates, 34.6% used CYP2D6 substrates, and 31.0% used CYP2C9 substrates. For migraine, 64.1% used CYP3A substrates, 44.0% used CYP2D6 substrates, and 28.9% used CYP2C9 substrates. In our analyses, the predicted DDI impact scores were highest for DDIs involving CYP3A, followed by CYP2D6, and CYP2C9 substrates, and highest for T2DM, followed by migraine, and obesity. Insights from RWD can be used to estimate a predicted DDI impact score for pharmacokinetic DDIs perpetrated by new drug candidates currently in development. This score can inform the risk/benefit profile of new drug candidates in a target patient population.