bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contemporary Agricultural Land Management Practices under Climate Change and Population Increase Scenarios: Insights from Tanzania’s Southern Highlands
Authors: Malekela Asnath Alberto , Sieber Stefan , Mapunda January , Chobo Jafari S 
Published: April 2024

This study investigated the impact of population growth and climate change on land management practices. The study was conducted in Mbinga district located in the Southern Highlands of Tanzania. Quantitative and qualitative research approaches were employed. Research data were collected using structured questionnaires, in-depth interviews, physical observation, focus group discussions and literature review. A total of 267 household heads were selected for this study. Also, the study used climate data from Tanzania Meteorological Authority, temperature and rainfall data over the past 40 years were collected (1981-2021). The findings revealed that, the area has experienced increased population and climate change incidences. The trend line for both minimum and maximum temperatures indicate a substantial increased trends at (P= 0.0018, R2=0.0005; P=0.0176, R2=0.02359) respectively. Contrariwise, the area has experienced decrease in rainfall totals at (P= 0.4385, R2=0.0008). It was revealed that, various traditional methods of land management practices including the use of animal manures, mulching, fallowing and the use of crop residues were affected by population increase and climate change. Farmers adopted new agricultural practices including the use of industrial fertilizers and reducing the size of contour terraces as the coping strategies for agricultural production against environmental deterioration caused by population increase and climate change. However, the sustainability of such practices is uncertain due to continued population increase and climate change scenarios. Therefore, the study recommends for introduction of sustainable land management practices that would instigate for sustainable food production for the changing population.
Gestão da Propriedade Intelectual em Instituição de Ensino Superior: uma revisão da literatura
Authors: Nakamura Márcio Akio , Fedato Geovana Alves de Lima , Gasparini Liz Vanessa Lupi 
Published: April 2024

A universidade é uma instituição com potencial para promover inovação em colaboração com governo e indústria no modelo de tripla hélice. Os ativos intelectuais criados no ambiente universitário, além de proteção, prescindem de um sistema de gestão. O objetivo desta pesquisa foi identificar e caracterizar as formas de gestão de Propriedade Intelectual (PI) propostas na literatura para Instituições de Ensino Superior (IES). O método utilizado foi de revisão sistemática da literatura com auxílio do Protocolo Prisma. Foram realizadas pesquisas na base de dados do periódico Capes e Scopus e selecionados nove artigos que compuseram o escopo da pesquisa. Os resultados demonstram que a gestão de PI envolve políticas externas e internas, favoráveis à inovação, sendo imprescindível o engajamento com os stakeholders. O gerenciamento da PI é realizado de várias formas, destacando-se a transferência de tecnologias por meio de escritórios. São utilizadas ferramentas como: benchmarking, cursos e treinamento de capacitação.
Propriedade Intelectual nas Universidades e Institutos Federais da Região Norte: um mapeamento com foco em programas de computador, marcas e patentes
Authors: Senna Yanka Andrade , Oliveira Junior Manoel Carlos de 
Published: April 2024

A Região Norte possui 11 Universidades Federais e sete Institutos Federais, abarcando áreas do conhecimento cujas produções são passíveis de proteção legal. O presente artigo analisa, entre 2012 e 2022, a atuação dessas instituições quanto ao desenvolvimento inovador e tecnológico, considerando: Programas de Computador e Marcas e Patentes. Quanto à metodologia, foram utilizados a análise documental, a pesquisa bibliográfica e a prospecção tecnológica junto ao Instituto Nacional da Propriedade Industrial (INPI) e a análise preditiva, utilizando a linguagem Python. A busca resultou em 39 Marcas, 550 Patentes e 301 Programas de Computador. A Universidade Federal do Pará se destaca com maior número de ativos de Propriedade Intelectual. Concluiu-se que o planejamento adequado dos NITs contribui para aumentar a proteção do conhecimento, como no caso da UFRA, da Unifap e da Ufopa. Entretanto, a análise preditiva mostra que não há tendência de crescimento, sendo necessárias ações que incentivem a proteção intelectual e o registro de marcas e softwares.
Highly Efficient Molybdenum(II)‐Catalyzed Intramolecular Allylic Alkylation of Arenes
Authors: Bandini Marco , Eichholzer Astrid , Kotrusz Peter , Umani‐Ronchi Achille 
Published: February 2008

AbstractThe Friedel–Crafts‐type intramolecular allylic alkylation of simple arenes is performed in the presence of a catalytic amount of [Mo(II) (CO)4Br2]2 (2.5 mol%). The moisture‐tolerant protocol provided a mild and direct access to a large library of functionalized 4‐vinyl‐1,2,3,4‐tetrahydronaphthalenes in high yields.
Prevalence and risk factors for pulmonary artery systolic hypertension among sickle cell disease patients in Nigeria
Authors: Aliyu Zakari Y. , Gordeuk Victor , Sachdev Vandana , Babadoko Aliyu , Mamman Aisha I. , Akpanpe Peter , Attah Ester , Suleiman Yusuf , Aliyu Nurudeen , Yusuf Jamilu , Mendelsohn Laurel , Kato Gregory J. , Gladwin Mark T. 
Published: February 2008

AbstractPulmonary artery systolic hypertension is common and associated with increased mortality among adult sickle cell disease (SCD) patients in the United States. Although the prevalence of SCD is highest in sub‐Saharan Africa, the frequency of pulmonary artery systolic hypertension and the risk factors for the development of pulmonary hypertension have not been reported from Africa. We studied 208 hydroxyurea naïve Nigerian SCD patients at steady state and 94 healthy controls. Pulmonary artery systolic hypertension was defined prospectively as tricuspid regurgitant jet velocity ≥2.5 m/sec. Results were compared with a previously published US prospective SCD cohort. Only 7% of Nigerians compared with 46% of US adults with SCD were >35 years. Tricuspid regurgitant jet velocity was ≥2.5 m/sec in 25% of Nigerian SCD patients. Higher jet velocity was associated with greater serum globulin (P = 0.002), blood urea nitrogen (P = 0.019) and lactate dehydrogenase concentrations (P = 0.026) and with inability to walk >300 m in 6 min (P = 0.042). Compared with the US cohort, Nigerian patients had more hemolysis as indicated by lower hemoglobin and higher lactate dehydrogenase concentrations (P ≤ 0.003). Pulmonary hypertension is common among Nigerian SCD patients. The public health implication of this finding is significant considering the potential number of individuals at risk for this complication. Better understanding of the long term outcome of pulmonary hypertension and causes of death in SCD and the institution of preventive measures are major public health challenges for Africa. The inclusion of African sites in sickle cell pulmonary hypertension clinical trials should be encouraged. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.
Isolated extramedullary relapse presenting as autologous lymphocyte response
Authors: Imataki Osamu , Ohnishi Hiroaki , Kitanaka Akira , Kubota Yoshitsugu , Tanaka Terukazu , Ishida Toshihiko 
Published: February 2008

AbstractIsolated EMR in the CNS is a relatively rare form of recurrent leukemia. We report here a case of a 38‐year‐old man with inv(16) acute myeloid leukemia (AML, M2) who suffered a central nervous system (CNS) relapse after allogeneic bone marrow transplantation (BMT) from a human leukocyte antigen (HLA)‐matched sibling donor. After complete remission was achieved by chemotherapy, he received allogeneic BMT from his HLA‐matched sister. His leukemia relapsed in the CNS 2.5 years after the allogeneic BMT. Lumbar puncture revealed 780/μL white blood cells with 67.3% leukemia cells and 32.7% mature lymphocytes. Fluorescent in situ hybridization (FISH) using a probe for the Y chromosome demonstrated that both leukemia cells and lymphocytes in the cerebrospinal fluid (CSF) were derived from the recipient, although the bone marrow cells were from the donor. No leukemia cells with inv(16) were detected by FISH in the bone marrow. This is the first report to clarify the chimerism of lymphocytes in the CSF of patients with isolated EMR in the CNS after allogeneic SCT, in which analysis revealed that autologous immunologic cells rather than donor lymphocytes responded to the recurrent isolated leukemic cells in CNS. This observation suggests that the CNS is a “sanctuary” site not only from chemotherapy but also from the graft‐versus‐leukemia effect. The present case contributes to our understanding of the possibility of immunological escape phenomenon of recurrent leukemia cells in extramedullary sites. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.
Plasma concentrations of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell patients but do not increase further during painful crisis
Authors: Landburg Precious P. , Teerlink Tom , Muskiet Frits A.J. , Duits Ashley J. , Schnog John‐John B. 
Published: February 2008

AbstractPlasma concentrations of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are elevated in the clinically asymptomatic state of sickle cell disease (SCD). However, the role of ADMA during vaso‐occlusive complications has not been defined. ADMA concentrations were determined in HbSS (n = 43) and HbSC (n = 25) patients with healthy blood donors (HbAA) as controls. In the clinically asymptomatic state ADMA concentrations were elevated in sickle cell patients as compared to healthy controls (HbSS 0.70 μmol/L, HbSC 0.54 μmol/L, HbAA 0.39 μmol/L) (P < 0.001). Yet plasma ADMA concentrations did not increase further at presentation with a painful crisis implicating no role of primary importance during vaso‐occlusive crises. Am. J. Hematol. 2008. © 2008 Wiley‐Liss, Inc.
Transfusion‐related acute lung injury following intravenous anti‐D administration in an adolescent
Authors: Berger‐Achituv Sivan , Ellis Martin H. , Curtis Brian R. , Wolach Baruch 
Published: February 2008

AbstractTransfusion‐related acute lung injury (TRALI) is associated with administration of all plasma containing blood products. We present a 14‐year‐old adolescent diagnosed with idiopathic thrombocytopenic purpura who developed acute respiratory insufficiency compatible with TRALI within 5 hr following intravenous anti‐D. Full blown noncardiogenic pulmonary edema was noted after 9 hr. Mechanical ventilation was not required and the patient made a full recovery after 36 hr. Analysis of the anti‐D preparation revealed reactivity against the neutrophil FcγRIIIb. A postinfusion serum sample contained antibodies against class I human HLA‐A11 antigen. Clinicians should consider TRALI in patients developing unexplained dyspnea after receiving intravenous anti‐D. Am. J. Hematol. 2008. © 2008 Wiley‐Liss, Inc.
Familial interstitial deletion of the short arm of chromosome 4 (p15.33–p16.3) characterized by molecular cytogenetic analysis
Authors: Basinko Audrey , Douet‐Guilbert Nathalie , Parent Philippe , Blondin Gilles , Mingam M. , Monot Françoise , Morel Frédéric , Le Bris Marie‐Josée , De Braekeleer Marc 
Published: February 2008

AbstractThis 15‐month boy was expressed at the cytogenetic laboratory because of psychomotor development delay. He was tall and had plagiocephaly, micrognathia, high nasal bridge, anteverted nostrils and pectus excavatum. A 46,XY,del(4)(p16.1p16.3) karyotype was found using high‐resolution R‐banding technique. FISH studies using the LSI Wolf–Hirschhorn dual color 4p16.3 and the TelVysion 4p probes showed no deletion. Using BACs, the distal breakpoint was located in 4p16.3, between RP11‐165K4 and RP11‐717M10 and the proximal breakpoint in 4p15.33, between RP11‐74M11 and RP11‐1J7; therefore, approximately 7.96 Mb of the short arm were deleted. The maternal karyotype showed the same deletion, but in a mosaic status. Two distinct phenotypes have been recognized on the basis of the chromosomal bands involved in 4p deletion: the Wolf–Hirschhorn syndrome (WHS) and a proximal 4p deletion syndrome (4p15.2–p15.32). Our observation confirms that the basic WHS phenotype maps distally to this region. © 2008 Wiley‐Liss, Inc.
Dysferlin‐deficient muscular dystrophy features amyloidosis
Authors: Spuler Simone , Carl Miriam , Zabojszcza Joanna , Straub Volker , Bushby Kate , Moore Steven A. , Bähring Sylvia , Wenzel Katrin , Vinkemeier Uwe , Rocken Christoph 
Published: February 2008

AbstractObjectiveDysferlin (DYSF) gene mutations cause limb girdle muscular dystrophy type 2B and Miyoshi's myopathy. The consequences of DYSF mutations on protein structure are poorly understood.MethodsThe gene encoding dysferlin was sequenced in patients with suspected dysferlin‐deficient muscular dystrophy. Muscle biopsy specimens were analyzed by histochemistry, immunohistochemistry, and electron microscopy. Antibodies against N‐terminal dysferlin‐peptides were raised.ResultsWe found three families with muscular dystrophy caused by homozygous or compound heterozygous DYSF mutations featuring sarcolemmal and interstitial amyloid deposits. These mutations were all located in the N‐terminal region of the protein. Dysferlin was a constituent of the amyloid deposits.InterpretationLimb girdle muscular dystrophy type 2B is the first muscular dystrophy associated with amyloidosis. Molecular treatment strategies will necessarily have to consider the presence of amyloidogenesis. Ann Neurol 2008
Lesion distribution in children with clinically isolated syndromes
Authors: Ghassemi Rezwan , Antel Samson B. , Narayanan Sridar , Francis Simon J. , Bar‐Or Amit , Sadovnick A. Dessa , Banwell Brenda , Arnold Douglas L. ,   Canadian Pediatric Demyelinating Disease Study Group
Published: February 2008

AbstractWe evaluated the incidence, volume, and spatial distribution of T2‐weighted magnetic resonance imaging lesions in 58 children with clinically isolated syndromes at risk for multiple sclerosis compared with 58 adults with relapsing‐remitting multiple sclerosis. Pediatric patients with clinically isolated syndromes who had brain lesions had supratentorial lesion volumes similar to adult multiple sclerosis patients, but greater infratentorial lesion volumes (p < 0.009), particularly in the pons of male patients. The predilection for infratentorial lesions the pediatric patients with clinically isolated syndromes may reflect immunological differences or differences in myelin, possibly related to the caudorostral temporal gradient in myelin maturation. Ann Neurol 2008
Muscle 3243A→G mutation load and capacity of the mitochondrial energy‐generating system
Authors: Janssen Antoon J. M. , Schuelke Markus , Smeitink Jan A. M. , Trijbels Frans J. M. , Sengers Rob C. A. , Lucke Barbara , Wintjes Liesbeth T. M. , Morava Eva , van Engelen Baziel G. M. , Smits Bart W. , Hol Frans A. , Siers Marloes H. , Ter Laak Henk , van der Knaap Marjo S. , Van Spronsen Francjan J. , Rodenburg Richard J. T. , van den Heuvel Lambert P. 
Published: February 2008

AbstractObjectiveThe mitochondrial energy‐generating system (MEGS) encompasses the mitochondrial enzymatic reactions from oxidation of pyruvate to the export of adenosine triphosphate. It is investigated in intact muscle mitochondria by measuring the pyruvate oxidation and adenosine triphosphate production rates, which we refer to as the “MEGS capacity.” Currently, little is known about MEGS pathology in patients with mutations in the mitochondrial DNA. Because MEGS capacity is an indicator for the overall mitochondrial function related to energy production, we searched for a correlation between MEGS capacity and 3243A→G mutation load in muscle of patients with the MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes) syndrome.MethodsIn muscle tissue of 24 patients with the 3243A→G mutation, we investigated the MEGS capacity, the respiratory chain enzymatic activities, and the 3243A→G mutation load. To exclude coinciding mutations, we sequenced all 22 mitochondrial transfer RNA genes in the patients, if possible.ResultsWe found highly significant differences between patients and control subjects with respect to the MEGS capacity and complex I, III, and IV activities. MEGS‐related measurements correlated considerably better with the mutation load than respiratory chain enzyme activities. We found no additional mutations in the mitochondrial transfer RNA genes of the patients.InterpretationThe results show that MEGS capacity has a greater sensitivity than respiratory chain enzymatic activities for detection of subtle mitochondrial dysfunction. This is important in the workup of patients with rare or new mitochondrial DNA mutations, and with low mutation loads. In these cases we suggest to determine the MEGS capacity. Ann Neurol 2008
Presumed perinatal ischemic stroke: Vascular classification predicts outcomes
Authors: Kirton Adam , DeVeber Gabrielle , Pontigon Ann‐Marie , Macgregor Daune , Shroff Manohar 
Published: February 2008

AbstractObjectivePerinatal stroke commonly causes childhood neurological morbidity. Presumed perinatal ischemic stroke (PPIS) defines children presenting outside a normal perinatal period with chronic, focal infarction on neuroimaging. Infarcts are assumed to represent arterial strokes, but recent evidence suggests the periventricular venous infarction (PVI) of infants born preterm may also occur in utero and present as PPIS. Using the largest published cohort, we aimed to define arterial and PVI PPIS syndromes and their outcomes.MethodsA PPIS consecutive cohort was identified (SickKids Children's Stroke Program, 1992–2006). Systematic neuroradiological scoring executed by blinded investigators included previously defined arterial stroke syndromes. PVI criteria included unilateral injury with at least four of the following conditions: (1) focal periventricular encephalomalacia, (2) internal capsule T2 prolongation, (3) cortical and (4) relative basal ganglia sparing, and (5) remote hemorrhage. Arterial and PVI classifications were validated and correlated with neurological outcomes (Pediatric Stroke Outcome Measure).ResultsIn 59 PPISs (64% male), 94% of lesions fell within potential middle cerebral artery territories. Although arterial proximal M1 infarction was most common (n = 19; 35%), venous PVI was second (n = 12; 22%) and accounted for 75% of subcortical injuries. Motor outcomes (mean follow‐up, 5.3 years) were predicted by basal ganglia involvement including leg hemiparesis, spasticity, and need for assistive devices (p < 0.01). Nonmotor outcomes were associated with cortical involvement, including cognitive/behavioral outcomes, visual deficits, and epilepsy (p < 0.01). Classification interrater reliability was excellent (correlation coefficients > 0.975).InterpretationRecognizable PPIS patterns predict long‐term morbidity and may guide surveillance, therapy, and counseling. PVI is an underrecognized cause of PPIS and congenital hemiplegia. Ann Neurol 2008
Material Applications for Salen Frameworks
Authors: Wezenberg Sander J. , Kleij Arjan W. 
Published: February 2008

AbstractSalens are among the most widely studied ligands in chemistry. They are primarily applied in homogeneous catalysis, a use that helps to increase our knowledge of environmentally benign and cost‐attractive chemical and/or pharmaceutical processes. Lately, the interest in salen chemistry has shifted to the use of these scaffolds in various other applications in which the immense versatility of the salen framework as a molecular building block can be exploited. Herein, we highlight the most recent research involving the incorporation of salen motifs in new materials and sophisticated catalysts.
Synthesis and properties of dimethacrylates—Derivatives of maleic and fumaric acids
Authors: Matynia Tadeusz , Podgórski Maciej 
Published: February 2008

AbstractIn this work, the synthesis as well as the mechanical and thermal properties of dimethacrylate copolymers are investigated. These copolymers were obtained from glycidyl methacrylate, maleic and/or fumaric acid adducts, methyl methacrylate, and/or styrene. The addition reaction of glycidyl methacrylate as well as maleic and fumaric acids was carried out in the presence of basic catalyst. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Time–temperature‐transformation (TTT) diagram of the isothermal crosslinking of an epoxy/amine system: Curing kinetics and chemorheology
Authors: Mounif E. , Bellenger V. , Tcharkhtchi A. 
Published: February 2008

AbstractRotational molding is a new process for thermosets, few research works have been done on this subject. The goal of this study is to determine the optimal conditions (time, temperature, viscosity, etc) of this process for an epoxy‐amine system. The thermal and rheological analysis help us to investigate the vitrification and the gelation of the reactive system (DGEBA‐DETDA) and to draw the TTT diagram. We have completed this diagram by adding the isoviscosity curves to determine the available domain for rotational molding. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Nylon 6/organoclay nanocomposites by extrusion
Authors: González Teresa Varela , Salazar Carlos Guerrero , De la Rosa Javier Rivera , González Virgilio González 
Published: February 2008

AbstractMontmorillonite‐layered silicates were modified with one tertiary alkylammonium salt (ALAS), to obtain nylon 6/montmorillonite nanocomposites. Nanocomposites were prepared by direct polymer melt‐intercalation, using two kinds of devices: twin‐screw extruder and a Brabender Plasticorder. Composites were made with different load clay to see the effect of them in the nylon composites. The modified clay was characterized by X‐ray diffraction (XRD), thermogravimetric analysis (TGA), and liquid nitrogen sorption; to evidence the intercalation of the ALAS among the layers of the montmorillonite. The nanocomposites were characterized by XRD, Fourier transform infrared spectroscopy, TGA, capillary rheometry, and mechanical tensile testing. The organoclay was well dispersed into the nylon 6 matrix when compounded with the twin‐screw extruder, but the use of a Brabender Plasticorder was less effective. The mechanical properties were modified, and the tensile modulus showed a relevant change compared with the pristine nylon 6. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008