bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age‐dependent gene expression profile and protein expression in a transgenic rat model of Huntington's disease
Authors: Nguyen Huu Phuc , Metzger Silke , Holzmann Carsten , Koczan Dirk , Thiesen Hans‐Jürgen , von Hörsten Stephan , Riess Olaf , Bonin Michael 
Published: October 2008

AbstractPolyglutamine‐induced changes in gene expression have been demonstrated by using several mouse models of Huntington's disease (HD), which express extreme numbers of CAG repeats. We have recently developed a transgenic rat model of HD carrying a truncated huntingtin fragment with 51 CAG repeats, which is in the range seen in adult HD patients. For further evaluation, we have performed microarray analyses on whole brains of transgenic rats at 3 and 12 months of age and correlated it with protein expression by Western blot analysis. We found that genes functionally associated with gene expression and behavior were differently regulated already at 3 months of age, whereas at 12 months of age especially genes related to neurological diseases and cell‐to‐cell signaling and interaction were dysregulated. A detailed analysis of canonical pathways revealed that at 3 months of age genes in calcium signaling and synaptic long term potentation pathways were altered, while at 12 months of age, additionally, expression level of many genes implicated in Huntington's disease signaling, were changed.
A recombinant chimeric antigen toward a standardized serodiagnosis of Taenia solium neurocysticercosis
Authors: Bae Young‐An , Jeong Yeon‐Tack , Chung Joon‐Yong , Kim Seon‐Hee , Mahanta Jagadish , Feng Zheng , Chong Chom‐Kyu , Kim Tong‐Soo , Kong Yoon 
Published: October 2008

AbstractNeurocysticercosis (NC) invokes formidable neurological problems worldwide. Previous proteomic analyses revealed most of the low‐molecular‐weight proteins might derive from two macromolecules of 120 kDa (consisting of 14–38 kDa subunits) and 150 kDa (7–15 kDa subunits) of Taenia solium metacestode (TsM) cyst fluid (CF). We characterized serological properties of these two proteins and established an immunopotent chimera. The 120 and 150 kDa proteins harbored 54–81 and 94–98% of the antibody‐binding activity of the crude CF with minimal antigenic cross‐reactivity to each other. The expression and immune recognition of the 150 kDa subunits were relatively constant, regardless of the different geographical origins of the CF collected, while those of the 120 kDa subunits varied by their origins (Asia vs. America). We cloned four representative proteins (one from the 120 kDa and three from the 150 kDa) that showed different epitope specificities, generated a chimera, and demonstrated that this regimen may bolster serodiagnostic reliability. Overall sensitivity and specificity, against sera from active‐/mixed‐stage NC and those from other infections, and healthy‐controls, were determined to be 97.5% (156/160 samples) and 97.8% (265/271 cases). Patient sera from adult taeniases, sparganosis, and fascioliasis showed weak cross‐reactions. Micro‐ELISA showed similar results. This chimera may prove useful in the construction of standardized platform for NC serodiagnosis.
Two dimensional gel electrophoresis of apolipoprotein C‐III and MALDI‐TOF MS are complementary techniques for the study of combined defects in N‐ and mucin type O‐glycan biosynthesis
Authors: Bruneel Arnaud , Morelle Willy , Carre Yoann , Habarou Florence , Dupont Damien , Hesbert Aurélie , Durand Geneviève , Michalski Jean Claude , Drouin‐Garraud Valérie , Seta Nathalie 
Published: October 2008

AbstractIn the field of diseases related to glycosylation disorders, congenital defects associated with abnormalities in both O‐ and N‐glycosylation of proteins constitute arising novel entities. Defects in subunits of the conserved oligomeric Golgi protein complex have been shown to be involved in an important part of previously unsolved CDG type II combining abnormalities in both mucin type core1 O‐ and N‐glycans; furthermore, recent studies revealed that autosomal recessive cutis laxa type II could also be associated with such combined glycosylation defects. Based on the studies of serum samples from three patients including a case of cutis laxa, we present here evidence that 2‐DE of apolipoprotein C‐III in combination with MALDI‐TOF‐MS analysis of serum O‐ and N‐glycans allow the detection and the biochemical characterization of these newly recognized glycosylation disorders.
Screw dislocations interacting with a coated inhomogeneity containing two imperfect interfaces
Authors: Fang Q. H. , Liu Y. W. , Liu T. X. , Wen P. H. 
Published: October 2008

AbstractThe interaction between screw dislocations, which are located at arbitrary points inside either the matrix or the inhomogeneity, and a circular coated inhomogeneity with two imperfect interfaces is investigated. The explicit solutions of the stress fields and strain energy are derived. With the aid of the Peach–Koehler formula, the explicit expressions of the image forces acting on the dislocations are derived for some cases. The mobility of the screw dislocation in the matrix is discussed for variable parameters (interface imperfection, material mismatch and dislocation position) and the influence of the nearby dislocations is also considered. The attractive force acting on the screw dislocation produced by the imperfect interfaces will increase with the increment of the degree of the interface imperfection. In addition, the mobility and stability of the screw dislocation are strongly influenced by nearby dislocations. The basic solutions provided in this paper can be used as Green's functions to solve the problem on the interaction between arbitrary shape crack and a coated inhomogeneity with imperfect interfaces. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Description of band structures of armchair nanotubes using the symmetry‐adapted linear augmented cylindrical wave method
Authors: D'yachkov P. N. , Makaev D. V. 
Published: October 2008

AbstractUsing a symmetry‐adapted linear augmented cylindrical wave method, the total band structures and the densities of states of the armchair single‐walled carbon nanotubes (SWNTs) (n,n) with 4 ≤ n ≤ 20, n = 30, 40, 60 and 100 are calculated. The approximations are made in the sense of muffin‐tin potentials and density functional theory only. The electronic states are presented as the functions of the two quantum numbers, namely, the continuous wave vector k corresponding to the screw symmetry operations and an integer rotational quantum number L between 0 and n – 1. An account of rotational and helical symmetry properties of the armchair SWNTs and particularly an introduction of the quantum number L permit to elaborate a more detailed classification of the armchair SWNTs electronic states. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Correlation between ionic charge and the optical properties of zinc blende and complex crystal structured solids
Authors: Verma A. S. 
Published: October 2008

AbstractAn overview of the understanding of correlation between ionic charge and the optical properties of zinc blende and chalcopyrite crystal structured solids is presented here. We have presented three expressions relating the refractive index (n), energy gap (Eg) and optical electronegativity (Δχ) for the transition metal chalcogenides and pnictides (AIIBVI and AIIIBV) and chalcopyrites (AIBIIIC2VI and AIIBIVC2V) with the product of ionic charges and nearest neighbor distance d (Å). The refractive index (n), energy gap (Eg) and optical electronegativity (Δχ) of these solids exhibit a linear relationship when plotted on a log–log scale against the nearest neighbour distance d (Å), but fall on different straight lines according to the ionic charge product of the compounds. We have applied the proposed relation on these solids and found a better agreement with the experimental data as compared to the values evaluated by earlier researchers. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
First atomistic studies of epitaxial growth of Na0.5Bi0.5TiO3 on SrTiO3
Authors: Petrov Petar , Guhl Hannes , Miller Wolfram 
Published: October 2008

AbstractThe first stages of epitaxial growth of Na0.5Bi0.5TiO3 on SrTiO3 substrates were studied by means of a newly developed kinetic Monte‐Carlo (KMC) model employing several types of particles, different types of neighbors and various energy barriers. Density functional method (DFT) has been used for computing the surface structure with adatoms and for obtaining some of the diffusion barriers. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Comparison of atmospheric pressure chemical ionization and electrospray ionization mass spectrometry for the detection of lignans from sesame seeds
Authors: Struijs Karin , Vincken Jean‐Paul , Gruppen Harry 
Published: October 2008

AbstractIn sesame seeds, high concentrations of lignans are present. When these lignans are fermented in the human colon, a range of structurally different lignans is formed. A good liquid chromatography/mass spectrometry (LC/MS) protocol for the analysis of lignans in complex mixtures is lacking. In order to develop such a protocol, electrospray ionization (ESI)‐MS and atmospheric pressure chemical ionization (APCI)‐MS, both in the positive and negative ionization mode, were compared. An extract from defatted sesame meal was analyzed by APCI‐MS and ESI‐MS, before and after deglucosylation. APCI‐MS was found to be a more generic method than ESI‐MS because lignans, especially sesamolin, sesamin and pinoresinol, were better detected by APCI‐MS than by ESI‐MS. Positive and negative ionization modes had to be combined in order to detect all lignans in a bacterial culture grown on aglyconic, acid‐treated lignans from sesame oil and defatted sesame meal. Lignans with methylenedioxy‐bridged furanofuran structures mostly lack phenolic hydroxyl groups and were, therefore, optimally detected in positive ionization mode. Dibenzylbutadiene lignans, which were formed during fermentation, carry hydroxyl groups and were better detected in negative ionization mode. Copyright © 2008 John Wiley & Sons, Ltd.
High‐performance liquid chromatography/mass spectrometric identification of dibenzylbutyrolactone‐type lignans: insights into electrospray ionization tandem mass spectrometric fragmentation of lign‐7‐eno‐9,9′‐lactones and application to the lignans of Linum usitatissimum L. (Common Flax)
Authors: Schmidt Thomas J. , Alfermann A. Wilhelm , Fuss Elisabeth 
Published: October 2008

AbstractIn continuation of our studies into the mass spectrometric detection of natural lignans and their identification in complex mixtures such as crude plant extracts, the electrospray ionization tandem mass spectrometric (ESI‐MS/MS) fragmentation of Δ7,8‐unsaturated dibenzylbutyrolactone‐type lignans (lign‐7‐eno‐9,9′‐lactones) was studied in detail. It is demonstrated that the characteristic fragmentation allows unambiguous identification including distinction between constitutional isomers. These lignans containing an α,β‐unsaturated lactone structure exist as equilibrium mixtures of E‐ and Z‐isomers indistinguishable by mass spectrometry, but it is shown that chromatographic retention time can be used to distinguish between the isomeric forms. Based on these observations, re‐analysis of the dichloromethane extract obtained from flowering aerial parts of Linum usitatissimum L. by high‐performance liquid chromatography (HPLC)/ESI‐MS/MS led to the identification of eighteen lignans of these types (five lignano‐ and one lignenolactone previously reported along with five further lignano‐ as well as seven lignenolactones hitherto unreported for this plant). The simultaneous identification of eighteen different lignans in the complex matrix of a crude plant extract by a single analysis demonstrates the potential of this method, which will certainly lead to new insights into the lignan composition and metabolism of different Linum species and many other plants. Copyright © 2008 John Wiley & Sons, Ltd.
TerraMax™: Team Oshkosh urban robot
Authors: Chen Yi‐Liang , Sundareswaran Venkataraman , Anderson Craig , Broggi Alberto , Grisleri, Paolo , Porta Pier Paolo , Zani Paolo , Beck John 
Published: October 2008

AbstractTeam Oshkosh, composed of Oshkosh Corporation, Teledyne Scientific and Imaging Company, VisLab of the University of Parma, Ibeo Automotive Sensor GmbH, and Auburn University, participated in the DARPA Urban Challenge and was one of the 11 teams selected to compete in the final event. Through development, testing, and participation in the official events, we experimented and demonstrated autonomous truck operations in (controlled) urban streets of California, Wisconsin, and Michigan under various climate and traffic conditions. In these experiments TerraMax™, a modified medium tactical vehicle replacement (MTVR) truck by Oshkosh Corporation, negotiated urban roads, intersections, and parking lots and interacted with manned and unmanned traffic while observing traffic rules. We accumulated valuable experience and lessons on autonomous truck operations in urban environments, particularly in the aspects of vehicle control, perception, mission planning, and autonomous behaviors, which will have an impact on the further development of large‐footprint autonomous ground vehicles for the military. In this article, we describe the vehicle, the overall system architecture, the sensors and sensor processing, the mission planning system, and the autonomous behavioral controls implemented on TerraMax. We discuss the performance of some notable autonomous behaviors of TerraMax and our experience in implementing these behaviors and present results of the Urban Challenge National Qualification Event tests and the Urban Challenge Final Event. We conclude with a discussion of lessons learned from all of the above experience in working with a large robotic truck. © 2008 Wiley Periodicals, Inc.
Genetic structure of island populations of the endangered bat Hipposideros turpis turpis: implications for conservation
Authors: Echenique‐Díaz Lázaro Miguel , Yokoyama Jun , Takahashi Osamu , Kawata Masakado 
Published: October 2008

AbstractEfforts for the conservation of the endangered bat species Hipposideros turpis turpis in southern Japan are hampered by a lack of information about its biology and natural history and by the increasing effect of human activities. In an attempt to address some of the conservation challenges faced by this species, we studied the genetic structure and dispersal of intra‐ and interisland populations using six species‐specific microsatellite markers. In particular, we sought to establish the relationship between island populations and to define effective management units for conservation. Pairwise co‐ancestry index (FST) analysis, analysis of molecular variance, and Bayesian clustering suggested the presence of significant genetic differentiation between islands but little differentiation within them. The small Yonaguni Island population appeared to be not only geographically isolated, but also genetically isolated. This population is at the greatest risk of extinction, considering its size and low genetic variation. The larger populations on Iriomote and Ishigaki Islands are genetically related to each other to a greater degree and exhibit higher genetic variation than the Yonaguni Island population. This suggests that these two island populations should be included in a single management unit, while bats from Yonaguni Island should be managed independently and given higher priority for conservation. Actions such as defining vegetation corridors between colonies, as well as building gates at the entrance of the largest known colony, should be included in the conservation agenda of this still poorly known species.
Dysplasia epiphysealis hemimelica of the talus
Authors: Azzoni Roberto 
Published: October 2008

Abstract
Dysplasia epiphysealis hemimelica is a rare developmental disorder with unknown etiology affecting epiphysis in childhood. The lesion is an osteochondroma arising from the epiphysis and increasing in size until skeletal maturity is reached. Surgical treatment is mandatory when symptoms such as pain, joint impingement or deformation are present, and yields good results when the mass is juxtaarticular or extraarticular. In those cases where articular symptoms are not present and only mass evolution is observed, surgical treatment is not recommended before skeletal maturity has been reached. A case of DEH located in the talus and successfully treated with surgery is presented.
Elevated cholesterol precursors other than cholestanol can also be a hallmark for CTX
Authors: de Sain‐van der Velden M. G. M. , Verrips A. , Prinsen B. H. C. M. T. , de Barse M. , Berger R. , Visser G. 
Published: October 2008

SummaryCerebrotendinous xanthomatosis (CTX) is an inborn error of bile acid synthesis in which hepatic conversion of cholesterol to cholic and chenodeoxycholic acids is impaired. Patients have abnormal bile alcohols in urine, normal to increased plasma cholesterol concentrations and increased concentrations of plasma cholestanol. Little is known about cholesterol precursors in CTX, however. We studied cholesterol and phytosterol profiles in two siblings with CTX during follow‐up. While cholesterol concentrations were low in both patients, plasma cholestanol was 6‐fold higher compared to control values. In addition, both siblings had a more than 100‐fold increase in 7‐dehydrocholesterol (7DHC) and 8‐dehydrocholesterol (8DHC). Lathosterol, lanosterol and sitosterol were increased in both patients while concentrations of desmosterol and campesterol were normal. In addition, plasma lathosterol/cholesterol ratios were significantly elevated. After treatment with chenodeoxycholate, both patients showed a marked decrease in cholestanol, 7DHC, 8DHC, lathosterol, lanosterol and sitosterol. In addition, the lathosterol/cholesterol ratio normalized, indicating that overall cholesterol synthesis was sufficiently suppressed. This study shows that elevated cholesterol precursors, other than cholestanol, can be a hallmark for CTX.
Perceptions of Familial Risk in those Seeking a Genetic Risk Assessment for Alzheimer's Disease
Authors: Hiraki Susan , Chen Clara A. , Roberts J. Scott , Cupples L. Adrienne , Green Robert C. 
Published: October 2008

AbstractPerceived risk is a complex concept that influences the genetic counseling process and can affect client coping and behavior. Although the association between family history and risk perception is well recognized in the literature, no studies have explored this relationship specifically in those seeking genetic susceptibility testing for a common chronic condition. REVEAL is a randomized trial assessing the impact of APOE disclosure and genetic risk assessment for Alzheimer's disease (AD). Using baseline REVEAL data, we hypothesized that there would be a significant association between the degree of AD family history and risk perception of AD, and that this relationship would be stronger in those who believed that genetics is a very important AD risk factor. In our sample of 293 participants, we found that a higher self‐perceived risk of AD was associated with strength of family history of AD (p < 0.001), belief in genetics as an important AD risk factor (p < 0.001), being female (p < 0.001) and being Caucasian (p = 0.02). These results are the first to demonstrate the association between family history and risk perception in persons volunteering for genetic susceptibility testing for a common complex disease.
Synthesis of Organic Dye-Impregnated Silica Shell-Coated Iron Oxide Nanoparticles by a New Method
Authors: Ren Cuiling , Li Jinhua , Liu Qian , Ren Juan , Chen Xingguo , Hu Zhide , Xue Desheng 
Published: October 2008

Abstract
A new method for preparing magnetic iron oxide nanoparticles coated by organic dye-doped silica shell was developed in this article. Iron oxide nanoparticles were first coated with dye-impregnated silica shell by the hydrolysis of hexadecyltrimethoxysilane (HTMOS) which produced a hydrophobic core for the entrapment of organic dye molecules. Then, the particles were coated with a hydrophilic shell by the hydrolysis of tetraethylorthosilicate (TEOS), which enabled water dispersal of the resulting nanoparticles. The final product was characterized by X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, photoluminescence spectroscopy, and vibration sample magnetometer. All the characterization results proved the final samples possessed magnetic and fluorescent properties simultaneously. And this new multifunctional nanomaterial possessed high photostability and minimal dye leakage.
Oral levosimendan in patients with severe chronic heart failure—The PERSIST study
Authors: Nieminen Markku S. , Cleland John G.F. , Eha Jaan , Belenkov Yuri , Kivikko Matti , Põder Pentti , Sarapohja Toni 
Published: October 2008

AbstractBackground:Intravenous levosimendan improves symptoms in acutely decompensated heart failure.Aims:To evaluate the effects of oral levosimendan in severe chronic heart failure (CHF).Methods:307 patients with NYHA IIIB–IV CHF were randomly assigned, double‐blind, to levosimendan 1 mg once or twice daily or placebo for at least 180 days. An exploratory primary end‐point, the Patient Journey, a composite consisting of repeated symptom assessments, worsening heart failure and mortality during 60 days was used. Minnesota Living with Heart Failure quality of life score (MLHFQoL) and NT‐proBNP were assessed repeatedly.Results:Patients assigned to a lower dose of levosimendan had more severe CHF at baseline. No differences in symptoms emerged and worsening heart failure events and death were similar resulting in a similar Patient Journey score with levosimendan and placebo (p=0.567). Compared to placebo, a net improvement of 3–4 points in MLHFQoL at several time‐points in favour of the combined levosimendan groups was observed (p<0.001) which was accompanied by a substantial and persistent reduction in NT‐proBNP (−30–40%) (p<0.001).Conclusion:Levosimendan improved QoL and decreased NT‐proBNP but did not improve the Patient Journey composite in patients with severe CHF. Further research with this compound is warranted to clarify safety and efficacy.
Modulation of transcriptional corepressor activity of prospero‐related homeobox protein (Prox1) by SUMO modification
Authors: Shan Shi-fang , Wang Lin-fang , Zhai Jian-wei , Qin Yi , Ouyang Hua-fang , Kong Yu-ying , Liu Jing , Wang Yuan , Xie You-hua 
Published: October 2008

MINT‐6787569:
PROX1 (uniprotkb:Q92786) physically interacts (MI:0218) with HDAC3 (uniprotkb:O15379) by anti tag coimmunoprecipitation (MI:0007)
MINT‐6787767:
PROX1 (uniprotkb:Q92786) physically interacts (MI:0218) with SUMO‐1 (uniprotkb:P63165) by anti tag coimmunoprecipitation (MI:0007)
Intranodal neurilemmoma presenting as parotid mass
Authors: Grant D G , Breitenfeldt N , Shepherd N A , Thomas D M 
Published: October 2008

AbstractObjective:We report a case of benign intranodal neurilemmoma, an extremely rare tumour arising from a nerve sheath within a lymph node.Case report:A 67-year-old woman underwent surgery for a left-sided parotid mass. Histopathological analysis revealed a tumour arising from a lymph node within the superficial lobe of the parotid gland. The tumour demonstrated histological features of an intranodal neurilemmoma.Conclusions:This case represents the first report of an intranodal neurilemmoma arising within a parotid lymph node, and supports the proposal that intranodal neurilemmoma be recognised as a distinct histological entity.