bluuebunny/crossref_metadata_2025_split huggingface dataset:
Household food security status and its associated factors among pensioners in Arba Minch town, South Ethiopia
Authors: Mamo Daniel Niguse , Worku Kassahun Misgana , Adem Yonas Fissha , Shibabaw Adamu Ambachew , Habte Aklilu , Haile Yosef 
Published: April 2024

IntroductionFood insecurity has remained a serious public health problem in developing countries, such as Ethiopia, over the past two decades. Vulnerable populations, such as pensioners, have been affected by this problem because of emerging socio-demographic changes, a global financial crisis, and climate change, all of which have contributed to the high food prices. Hence, this study aimed to assess household food security status and associated factors among pensioners in Arba Minch town, South Ethiopia.MethodsA community-based cross-sectional study design was conducted from September to October 2023. Two hundred forty-four pensioners were chosen using a simple random sampling technique. Data were collected, cleaned, and entered into EPI-Data version 4.6 and exported to SPSS version 25 for analysis. Variables with a p-value of ≤0.25 in the bivariate analyses were candidates for the multivariable regression analysis. In the multivariable logistic regression, variables with a p-value of 0.05 were considered to have a significant association with the dependent variable.ResultsA total of 238 retired people were interviewed, with a response rate of 97.5%. Among the interviewed pensioners, 223 (91.4%) households were food insecure. Having more than one dependent member [AOR = 2.4, 95% C.I: 1.30, 6.64], being jobless after retirement [AOR = 3, 95% C.I:1.17, 5.61], and being in the lowest tertile of wealth status [AOR = 2, 95% C.I:1.36, 4.99] were identified as predictors of food insecurity.ConclusionThe magnitude of household food insecurity was higher compared to the national average, and factors such as the current occupational status of the household head, dependency ratio, and wealth status of the household were significantly associated with household food insecurity. Therefore, policymakers and programmers should provide new strategies focusing on additional income-generating activities and salary increments and consider free services such as school fees and healthcare.
A case report and literature review on tocilizumab-cured acute necrotizing encephalopathy caused by influenza A virus
Authors: Huang YuKun , Zhou Bin , Hong ShaoXian , Cai YaLi 
Published: April 2024

IntroductionAcute Necrotizing Encephalopathy (ANE), is a kind of severe Central Nervous System Disease. The commonest pathogen is the influenza virus. The pathogenesis of ANE is bound up to genetic susceptibility and cytokine storm. Interleukin-6 (IL-6) is deemed as the core function in cytokine storm of ANE and that plays a significant role in evaluating the severity of Influenza-Related ANE. Tocilizumab, an IL-6 antagonist, is known to be safe and effective in the treatment of ANE when used early and has an essential role in improving prognosis and preventing disability.Case reportThis case reports a 2 year 10 month old boy who developed ANE after being infected with influenza A virus (H1N1-2019). After treatment with Tocilizumab, the child's consciousness was clear, no convulsions occurred, the movement of limbs was improved, and the lesions of encephalopathy were significantly reduced.ConclusionThe early use of Tocilizumab is safe and effective for the treatment of ANE caused by influenza virus.
Lipophilic analogues of D-cysteine prevent and reverse physical dependence to fentanyl in male rats
Authors: Bates James N. , Getsy Paulina M. , Coffee Gregory A. , Baby Santhosh M. , MacFarlane Peter M. , Hsieh Yee-Hsee , Knauss Zackery T. , Bubier Jason A. , Mueller Devin , Lewis Stephen J. 
Published: April 2024

We examined whether co-injections of the cell-permeant D-cysteine analogues, D-cysteine ethyl ester (D-CYSee) and D-cysteine ethyl amide (D-CYSea), prevent acquisition of physical dependence induced by twice-daily injections of fentanyl, and reverse acquired dependence to these injections in freely-moving male Sprague Dawley rats. Injection of the opioid receptor antagonist, naloxone HCl (NLX, 1.5 mg/kg, IV), elicited a series of withdrawal phenomena that included cardiorespiratory and behavioral responses, and falls in body weight and body temperature, in rats that received 5 or 10 injections of fentanyl (125 μg/kg, IV), and the same number of vehicle co-injections. Regarding the development of physical dependence, the NLX-precipitated withdrawal phenomena were markedly reduced in fentanyl-injected rats that had received co-injections of D-CYSee (250 μmol/kg, IV) or D-CYSea (100 μmol/kg, IV), but not D-cysteine (250 μmol/kg, IV). Regarding reversal of established dependence to fentanyl, the NLX-precipitated withdrawal phenomena in rats that had received 10 injections of fentanyl (125 μg/kg, IV) was markedly reduced in rats that received co-injections of D-CYSee (250 μmol/kg, IV) or D-CYSea (100 μmol/kg, IV), but not D-cysteine (250 μmol/kg, IV), starting with injection 6 of fentanyl. This study provides evidence that co-injections of D-CYSee and D-CYSea prevent the acquisition of physical dependence, and reverse acquired dependence to fentanyl in male rats. The lack of effect of D-cysteine suggests that the enhanced cell-penetrability of D-CYSee and D-CYSea into cells, particularly within the brain, is key to their ability to interact with intracellular signaling events involved in acquisition to physical dependence to fentanyl.
Antimicrobial photodynamic therapy for dermatological infections: current insights and future prospects
Authors: Almenara-Blasco M. , Pérez-Laguna V. , Navarro-Bielsa A. , Gracia-Cazaña T. , Gilaberte Y. 
Published: April 2024

Introduction:Light-based antimicrobial photodynamic therapy (aPDT) shows promise against a wide range of microorganisms, including drug-resistant strains, with low resistance development likelihood. However, its limitations include the need for light exposure, suitability for local infections, and limited industry interest. Relevant studies on aPDT for various infections are discussed.Methods:We conducted an extensive literature review on aPDT encompassing articles published from the year 2000 to the current date. To compile comprehensive data, multiple databases (PubMed, Web of Science, Scopus, and Cochrane Library) were systematically searched for relevant studies in both English and Spanish languages. The search strategy involved a combination of Medical Subject Headings (MeSH) terms and free-text terms. The terms included variations and combinations of “Antimicrobial Photodynamic Therapy,” “aPDT,” “photodynamic inactivation,” “microbial photoinactivation,” among others. To ensure the reliability and quality of the information gathered, articles were screened based on relevance to aPDT in antimicrobial therapy, methodological rigor, and alignment with the objectives of this review.Results:aPDT shows promise in treating various cutaneous infections. It effectively targets fungal infections, including caused by dermatophytes and Malassezia spp., with notable results against dermatophytosis and tinea capitis. New photosensitizers, like nanoencapsulated hypericin, hold potential for treating these infections. In onychomycosis, aminolevulinic acid-aPDT or methylene blue-aPDT offers an alternative to conventional therapies, showing cure rates as high as 90%. For bacterial infections, it presents a solution against antibiotic-resistant strains and infected ulcers, with potential benefits for wound healing. Regarding viral infections, it indirectly targets viruses by impacting host cells’ metabolism, showing efficacy against human papillomavirus and herpes viruses. Lastly, aPDT demonstrates success in treating parasitic infections, particularly leishmaniasis, with cure rates of up to 100%.Discussion:aPDT is increasingly used in dermatological infections, showing efficacy against various microorganisms and stimulating wound healing. It can combat resistant strains and mixed infections, especially in chronic wounds. Combining photodynamic therapy with antimicrobials is a promising strategy to address antimicrobial resistance, but there are practical limitations. Further research is needed for home-based protocols, portable devices, and adapting photosensitizers, as aPDT holds potential as an alternative treatment for recalcitrant infections and immunosuppressed patients, though challenges remain in application.
Parenting by mothers from marginalized communities and the role of socioeconomic disadvantage: insights from marginalized Roma communities in Slovakia
Authors: Van Laer Stanislava , Fiľakovská Bobáková Daniela , Kolarcik Peter , Engel Ofer , Madarasová Gecková Andrea , Reijneveld Sijmen A. , de Kroon Marlou L. A. 
Published: April 2024

BackgroundRoma living in marginalized communities often face poor living conditions and material deprivation, which may negatively impact parenting. Our aim is to compare the parenting behavior (support, harsh discipline, and stimulation) of mothers from marginalized Roma communities and the majority population in Slovakia. We also examine the role of socioeconomic disadvantage and related worries in the differences in parenting behavior between these groups.MethodsWe obtained cross-sectional data from mothers of children aged 14–18 months using the first wave of the longitudinal RomaREACH study dataset. Two groups were included in the sample: 93 mothers from MRCs and 102 mothers from the majority. We performed multiple regression and mediation analyses to assess whether the educational level of mothers, the degree of poverty, and poverty-related feelings of stress and worries explain parenting behavior differences between the groups of mothers.ResultsWe found significant differences in parenting, especially in harsh disciplining and stimulation. These two domains were significantly associated with maternal education, degree of poverty, and poverty-related stress and worries. The degree of poverty partially mediated stimulation differences between the two groups of mothers.ConclusionParenting in MRCs seems harsher and less stimulative than parenting in the Slovak majority. These differences are associated with the socioeconomic disadvantage of mothers. The degree of poverty partially explains why parenting in MRCs is less stimulative. These results may inform intervention efforts aimed at disadvantaged families.
Temperament and emotional overeating: the mediating role of caregiver response to children’s negative emotions
Authors: Ju Sehyun , Iwinski Samantha , Bost Kelly K. 
Published: April 2024

ObjectiveThis study aimed to investigate the mediating effects of caregiver responses to a child’s negative emotions on the associations between infant temperament and emotional overeating in preschool children.MethodA sample of 358 children and their caregivers enrolled in the STRONG Kids 2 (SK2) birth cohort study (N = 468) provided data for this analysis. Caregivers completed questionnaires assessing child temperament at 3 months, caregiver response to negative emotions at 18 months, and child emotional overeating at 36 months. Structural Equation Modeling was conducted using the lavaan package in RStudio to test hypothesized models examining whether the relations between early temperament and subsequent emotional eating were mediated by caregiver responses to a child’s emotions.ResultsFindings revealed that infant temperamental orienting/regulation predicted the later development of emotional overeating through supportive caregiver responses to a child’s negative emotions. Lower levels of orienting/regulation were associated with greater emotional overeating, explained by less supportive caregiver responses to the child’s emotions. Moreover, infant surgency had a positive direct influence on emotional overeating at 36 months. Both supportive and non-supportive caregiver responses to a child’s negative emotions had significant direct influences on emotional overeating.ConclusionThe results highlight the importance of caregiver response to a child’s negative emotions as a mediator between infant temperament and emotional overeating in preschool children. Intervention strategies can be implemented to support caregivers in adopting supportive responses to their child’s negative emotions to promote healthy eating behaviors from early childhood. Future studies are needed to explore these pathways of influences throughout child development.
Damage to the public health system caused by war-related looting or vandalism in the Tigray region of Northern Ethiopia
Authors: Gufue Zenawi Hagos , Haftu Hiluf Kalayou , Alemayehu Yibrah , Tsegay Etsay Weldekidan , Mengesha Meresa Berwo , Dessalegn Berhe 
Published: April 2024

BackgroundThe war that started on November 4, 2020, in the Tigray region of Northern Ethiopia severely affected the health sector. However, there is no available evidence to suggest the economic damage caused to the public health system because of war-related looting or vandalism. This study was aimed at estimating the cost of war-related looting or vandalism in Tigray’s public health system in Northern Ethiopia in 2021.MethodsA provider perspective, a mixed costing method, a retrospective cross-sectional approach, a 50% inflation rate, and a 50 Ethiopian birr equivalent to one United States dollar ($) for the money value were used. The data were analyzed using Microsoft Excel, taking into consideration the Sendai framework indicators.ResultsThe total economic cost of the war-related looting or vandalism in monetary terms was more than $3.78 billion, and the damage to the economic value in monetary terms was more than $2.31 billion. Meanwhile, the direct economic loss to the health system in monetary terms was more than $511 million. According to this assessment, 514 (80.6%) health posts, 153 (73.6%) health centers, 16 (80%) primary hospitals, 10 (83.3%) general hospitals, and 2 (100%) specialized hospitals were damaged and/or vandalized either fully or partially due to the war.ConclusionThis war seriously affected the public health sector in the Tigray region. The Federal Government of Ethiopia, the Ministry of Health of Ethiopia, the Tigrayan Government, the Tigray Regional Health Bureau, and the international community must make efforts to find resources for the revitalization of the damaged, plundered, and vandalized healthcare system.
Assessment of burnout, resilience, and thriving among academic health professionals: findings from an international study
Authors: Nahas Abdul Rahman Fata , Elnaem Mohamed Hassan , Mubarak Naeem , Khatwa Merna Abou , Barakat Muna , Faller Erwin , Kassem Lamyaa M. , Ramatillah Diana Laila , Jaber Ammar , Akkawi Muhammad Eid , Al-Shami Abdulkareem Mohammed , Chandran Sarath , Mohamed Islam , Jack Iain , Abouelhana Ahmed , Courtenay Aaron , Elrggal Mahmoud E. 
Published: April 2024

IntroductionBurnout, resilience, and thriving significantly impact academics, particularly in health professions, where responsibilities are extensive. This study aimed to explore these constructs among academic health professionals, examining sociodemographic and work-related factors influencing these outcomes.MethodsA cross-sectional study was conducted among academic health professionals via web-based professional networks from August 2022 to February 2023. Validated tools were used, and descriptive and inferential statistics were applied.Results505 participants were included, predominantly female (63%), with a mean age of 38.15 ± 9.6 years. High burnout was reported by 10.9%, 13.7% experienced exhaustion, and 6.3% were disengaged. Resilience and thriving were moderate at 59.2 and 51.9%, respectively. Age correlated negatively with burnout (r = −0.131, p = 0.003) but positively with resilience (r = 0.178, p &lt; 0.001). Females reported higher exhaustion (p = 0.014), while males showed greater resilience (p = 0.016). Instructors exhibited lower resilience compared to assistant professors (p &lt; 0.001) and associate professors (p &lt; 0.001). Those at public universities reported higher exhaustion than those at private universities (p &lt; 0.001).ConclusionVariable levels of burnout, resilience, and thriving were observed among academic health professionals, influenced by sociodemographic and work-related factors. Interventions targeting resilience and thriving may mitigate burnout risk and enhance engagement among academics in health professions.
Application of machine learning for lung cancer survival prognostication—A systematic review and meta-analysis
Authors: Didier Alexander J. , Nigro Anthony , Noori Zaid , Omballi Mohamed A. , Pappada Scott M. , Hamouda Danae M. 
Published: April 2024

IntroductionMachine learning (ML) techniques have gained increasing attention in the field of healthcare, including predicting outcomes in patients with lung cancer. ML has the potential to enhance prognostication in lung cancer patients and improve clinical decision-making. In this systematic review and meta-analysis, we aimed to evaluate the performance of ML models compared to logistic regression (LR) models in predicting overall survival in patients with lung cancer.MethodsWe followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. A comprehensive search was conducted in Medline, Embase, and Cochrane databases using a predefined search query. Two independent reviewers screened abstracts and conflicts were resolved by a third reviewer. Inclusion and exclusion criteria were applied to select eligible studies. Risk of bias assessment was performed using predefined criteria. Data extraction was conducted using the Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modeling Studies (CHARMS) checklist. Meta-analytic analysis was performed to compare the discriminative ability of ML and LR models.ResultsThe literature search resulted in 3,635 studies, and 12 studies with a total of 211,068 patients were included in the analysis. Six studies reported confidence intervals and were included in the meta-analysis. The performance of ML models varied across studies, with C-statistics ranging from 0.60 to 0.85. The pooled analysis showed that ML models had higher discriminative ability compared to LR models, with a weighted average C-statistic of 0.78 for ML models compared to 0.70 for LR models.ConclusionMachine learning models show promise in predicting overall survival in patients with lung cancer, with superior discriminative ability compared to logistic regression models. However, further validation and standardization of ML models are needed before their widespread implementation in clinical practice. Future research should focus on addressing the limitations of the current literature, such as potential bias and heterogeneity among studies, to improve the accuracy and generalizability of ML models for predicting outcomes in patients with lung cancer. Further research and development of ML models in this field may lead to improved patient outcomes and personalized treatment strategies.
The effect of land cover on the foraging behavior and pollen in the honey of the giant bee Apis dorsata in Sumatra
Authors: Raffiudin Rika , Dyahastuti Meis , Nugraha Rahmia , Sayusti Tiara , Djuita Nina Ratna , Suwananda Erik , Allvioningrum Vera , Mardhony Reza , Biagioni Siria , Setyaningsih Christina Ani , Prasetyo Lilik Budi , Priawandiputra Windra , Atmowidi Tri , Saad Asmadi , Behling Hermann 
Published: April 2024

IntroductionApis dorsata, the common bee pollinator in tropical forests, is experiencing a population decrease due to several anthropogenic factors that lead to land cover changes and habitat loss. Land cover changes may alter their resource supply and foraging behavior. Our study aimed to determine foraging behavior and botanical origin using pollen of A. dorsata honey in two land cover types: plantationdominated landscape (PL) in Kampar (Riau) and forest-agriculture-dominated landscape (FL) in Kerinci (Jambi) Sumatra, Indonesia.MethodsWe observed two colonies of A. dorsata flight direction and flight activities in each land cover from 9 am–3pm. Honey was harvested from both nests of A. dorsata and the pollen in the honey was analyzed using acetolysis procedure. Vegetation analysis in both locations was conducted based on the flight directions of the giant honey bees.ResultsThe foraging data of A. dorsata showed a difference in the total number of bees between these two land cover types. The number of bees flying out and returning to the nest was higher in Kerinci than in Kampar, while high morning foraging activities were recorded in both land cover types. Furthermore, the foraging activity of the colonies in the PL landscape, i.e., flying out and returning to the nest with and without pollen, decreased at noon. The palynological results of the honey showed that in the PL landscape, pollen diversity was very low and mainly consisted of Elaeis gueneensis pollen (97%). Meanwhile, pollen types and concentrations were much higher in the FL than in the PL.DiscussionThis result suggests that A. dorsata exhibits a more varied foraging behavior in a diverse and heterogeneous landscape in Kerinci compared to a plantation-dominated habitat in Kampar.
Apneustic anesthesia ventilation improves pulmonary function in anesthetized bottlenose dolphins (Tursiops truncatus)
Authors: Le-Bert Carolina R. , Bukoski Alex , Downs John , Hodgson David S. , Thombs Lori , Ridgway Sam H. , Bailey James 
Published: April 2024

IntroductionUse of mechanical ventilation during general anesthesia is a necessary practice in the anesthetization of small cetaceans as spontaneous ventilation fails to provide adequate gas exchange. Currently available methods of ventilation do not account for the intermittent breathing strategy of representative species within this infraorder of fully aquatic mammals and may have a significant effect on cardiac and respiratory physiology.MethodsTo understand the impact of mechanical ventilation on cardiopulmonary function in one small species of cetacean, the bottlenose dolphin (Tursiops truncatus), we compared controlled mechanical ventilation (CMV) to a novel ventilation method known as apneustic anesthesia ventilation (AAV). AAV simulates the normal inspiratory breath-hold pattern of dolphins. Ten anesthetic procedures (dental procedure, n = 9; bronchoscopy, n = 2) were performed on nine dolphins (age range: 10–42 years; mean = 32 years; median = 37 years; female = 3, 40%; male = 6, 60%). In a cross-over study design, dolphins were instrumented and randomly assigned to AAV or CMV as the initial mode of ventilation, then switched to the alternate mode. Baseline cardiopulmonary data were collected and again after 30 min on each mode of ventilation. Cardiac index, stroke volume index, systemic vascular resistance, alveolar dead space, alveolar-arterial oxygen tension gradient, arterial oxygen content, oxygen delivery index, and dynamic respiratory system compliance index were calculated at each of the four time points.ResultsDuring AAV, dolphins had higher arterial oxygen tension, higher mean airway pressure, reduced alveolar dead space ventilation and lower alveolar-arterial oxygen difference. Cardiovascular performance was not statistically different between the two modes.DiscussionOur study suggests AAV, which more closely resembles the conscious intermittent respiratory pattern phenotype of dolphins, improves ventilation and pulmonary function in the anesthetized dolphin. Future studies should evaluate the cardiopulmonary effects of neutral buoyancy and cardiopulmonary sparing drug protocols to reduce the need for hemodynamic support of current protocols.