bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lidocaine in the middle ear
Authors: Wilson David F. , Hodgson Richard S. 
Published: October 2006

AbstractAnesthesia of the ear canal is produced by injection of lidocaine hydrochloride into the skin of the lateral external ear canal. Ear canal, tympanic membrane, and middle ear surgeries are performed with this injection. The fluid found in the middle ear during tympanotomy was collected and analyzed. The percentage of lidocaine in the fluid was calculated by an enzyme immunoassay technique. Fifteen surgical cases were undertaken in which perilymphatic fluid in the middle ear would not be suspected, such as tympanotomy for otosclerosis. Lidocaine was found in all middle ears in which there was sufficient fluid to collect. The authors question the validity of using the presence of clear fluid in the middle ear, even with reaccumulation, as the sole criterion for identifying perilymph and cerebrospinal fluid.
Gentamicin iontophoresis in the treatment of bacterial otitis externa in the guinea pig model
Authors: King III Dana M. , Estrem Scott A. 
Published: October 2006

AbstractPseudomonas otitis externa is one of the most common infections treated by otolaryngologists. Infections induced in 30 guinea pigs appeared similar to that seen in humans. The ears were then placed into four treatment groups: group A, which received a single cleaning; group B, which received a single cleaning followed by gentamicin drops 4 times daily; group C, which received a single cleaning followed by a single gentamicin iontophoresis treatment; and group D, the control group, which received no treatment.Infections were analyzed by grading edema, purulence, and erythema. An average of 10.2 days was required for control group to return to normal appearance. Groups A, B, and C had mean resolution times of 5.9, 4.7, and 4.3 days, respectively.Gentamicin iontophoresis appears to be promising, with results as good as drop therapy in otitis externa in the guinea pig model.3
Concomitant chemotherapy and split‐course radiation for cure and preservation of speech and swallowing in head and neck cancer
Authors: Hirsch Steven M. , Caldarelli David D. , Hutchinson James C. , Holinger Lauren D. , Showel John L. , Taylor Samuel G. , Murthy Anantha K. 
Published: October 2006

AbstractTo assess the ability of simultaneous cisplatin, 5‐Fluorouracil, and radiation to substitute for surgery and radiation in advanced head and neck cancer, we have retrospectively selected from our phase II study a subgroup of 29 patients having primary disease requiring either more than a hemiglossec‐tomy or a laryngectomy for control. Patients included 22 with stage IV and 7 with stage III disease, 12 tongue, 10 hypopharynx, and 7 larynx primaries. The treatment consisted of concurrent cisplatin, 5‐Fluo‐rouracil, and split‐course radiation every other week for a total of 7 cycles within 13 weeks. With a median follow‐up of 5 years, 86% of patients had preservation of speech and/or swallowing function. Median survival was 45 months, with 14 (48%) patients currently alive and disease free, 11 (38%) dead from their cancer, and 4 (14%) dead of other causes. The overall failure rate was 38%. Advanced‐stage presence of N3 nodal disease and fewer than 7 cycles of chemotherapy received were significantly associated with increasing failure rates. This program of concomitant cisplatin, 5‐Fluorouracil, and radiation produced control rates quite competitive with surgery and radiation and is appropriate for definitive testing in a randomized trial.
Prophylactic antibiotic use in clean, uncontaminated neck dissection
Authors: Slattery William H. , Stringer Scott P. , Cassisi Nicholas J. 
Published: October 2006

AbstractA recent report in the literature cites a 10% wound infection rate for clean, uncontaminated neck dissections in patients who did not receive antibiotic prophylaxis as compared with a 3.3% infection rate in patients who received prophylactic antibiotics. Although a trend favoring antibiotic prophylaxis was identified, the duration of therapy was not considered. The present analysis addresses this issue. The authors retrospectively reviewed the records of 120 patients who underwent clean, uncontaminated neck dissections over a 3‐year period (July 1989 through May 1992) for variables related to wound infections. Radiation therapy had previously been used in 70% of these patients. Group 1 (31 patients) received 24 hours of perioperative antibiotic prophylaxis, and group 2 (89 patients) received antibiotic prophylaxis until the suction drains were removed (usually 4 or 5 days after surgery). No perioperative wound infections occurred in either group. The authors concluded that perioperative antibiotic prophylaxis for 24 hours is sufficient to prevent wound infections in clean, uncontaminated neck dissections.
Atorvastatin Effect on Circulating and Leukocyte‐Produced CD40 Ligand Concentrations in People with Normal Cholesterol Levels: A Pilot Study
Authors: Zineh Issam , Welder Gregory J. , DeBella Amy E. , Arant Christopher B. , Wessel Timothy R. , Schofield Richard S. 
Published: October 2006

Study Objectives. To investigate whether atorvastatin decreases serum or leukocyte‐produced CD40 ligand (CD40L) levels and whether these effects are dependent on reduction in low‐density lipoprotein cholesterol (LDL) levels in people without overt dyslipidemia.Design. Prospective pilot study.Setting. University research center.Subjects. Twenty‐five normocholesterolemic volunteers (mean age 32 ± 11 yrs; 15 women, 10 men) without cardiovascular disease.Intervention. After a 2‐week drug‐free run‐in period, subjects received atorvastatin 80 mg/day orally for 16 weeks.Measurements and Main Results. All lipoprotein level measurements were performed with the subject in the fasting state. The CD40L concentrations were measured by immunofluorescence detection in serum and leukocyte culture supernates after 24‐hour incubation, and treatment effect was analyzed. Baseline mean ± SD total cholesterol, LDL, high‐density lipoprotein cholesterol, and triglyceride levels were 179 ± 33, 97 ± 29, 62 ± 20, and 102 ± 69 mg/dl, respectively. Mean changes in each of these levels, respectively, after 16 weeks of atorvastatin were −34%, −59%, +3%, and −23%. The median serum CD40L level was lower at 16 weeks (2.3 ng/ml, interquartile range [IQR] 1.2–5.0 ng/ml) than at baseline (3.0 ng/ml, IQR 2.1–3.7 ng/ml), but the change was not significant (p=0.24). However, atorvastatin significantly lowered CD40L produced from leukocytes by 57% (21 pg/mg of protein [IQR 10–38 pg/mg] vs 49 pg/mg [IQR 21–149 pg/mg], p=0.045). Effects were independent of reduction in cholesterol levels.Conclusion. Although atorvastatin did not significantly lower serum CD40L levels, significant reduction in leukocyte production was seen independent of degree of LDL reduction. These pilot data suggest a potential benefit in normocholesterolemic individuals that should be further investigated, and that leukocyte CD40L concentrations should be considered in the drug response.
Scaled quantum chemical studies of the structural and vibrational spectra of acetyl coumarin
Authors: Bahgat Khaled 
Published: October 2006

Abstract
The solid phase FT-IR and FR-Raman spectra of acetyl coumarin have been recorded in the regions 4000–50 cm−1. The spectra were interpreted with the aid of normal coordinate analysis following full structure optimization and force field calculations based on density functional theory (DFT) and Hartree-Fock (HF) at 6–31G* and 6–311++G** basis sets. The resulting force fields were transformed to internal coordinates, the calculated vibrational frequencies and normal modes were utilized in the assignment of the observed vibrational fundamentals. The measured spectral data were used to refine the vibrational force constants by means of a small number of scaling factors.
Allergic Rhinitis
Authors: Bernstein Jonathan A. , Bernstein Joshua S. , Makol Richika , Ward Stephanie 
Published: March 2024

ImportanceAllergic rhinitis affects an estimated 15% of the US population (approximately 50 million individuals) and is associated with the presence of asthma, eczema, chronic or recurrent sinusitis, cough, and both tension and migraine headaches.ObservationsAllergic rhinitis occurs when disruption of the epithelial barrier allows allergens to penetrate the mucosal epithelium of nasal passages, inducing a T-helper type 2 inflammatory response and production of allergen-specific IgE. Allergic rhinitis typically presents with symptoms of nasal congestion, rhinorrhea, postnasal drainage, sneezing, and itching of the eyes, nose, and throat. In an international study, the most common symptoms of allergic rhinitis were rhinorrhea (90.38%) and nasal congestion (94.23%). Patients with nonallergic rhinitis present primarily with nasal congestion and postnasal drainage frequently associated with sinus pressure, ear plugging, muffled sounds and pain, and eustachian tube dysfunction that is less responsive to nasal corticosteroids. Patients with seasonal allergic rhinitis typically have physical examination findings of edematous and pale turbinates. Patients with perennial allergic rhinitis typically have erythematous and inflamed turbinates with serous secretions that appear similar to other forms of chronic rhinitis at physical examination. Patients with nonallergic rhinitis have negative test results for specific IgE aeroallergens. Intermittent allergic rhinitis is defined as symptoms occurring less than 4 consecutive days/week or less than 4 consecutive weeks/year. Persistent allergic rhinitis is defined as symptoms occurring more often than 4 consecutive days/week and for more than 4 consecutive weeks/year. Patients with allergic rhinitis should avoid inciting allergens. In addition, first-line treatment for mild intermittent or mild persistent allergic rhinitis may include a second-generation H1 antihistamine (eg, cetirizine, fexofenadine, desloratadine, loratadine) or an intranasal antihistamine (eg, azelastine, olopatadine), whereas patients with persistent moderate to severe allergic rhinitis should be treated initially with an intranasal corticosteroid (eg, fluticasone, triamcinolone, budesonide, mometasone) either alone or in combination with an intranasal antihistamine. In contrast, first-line therapy for patients with nonallergic rhinitis consists of an intranasal antihistamine as monotherapy or in combination with an intranasal corticosteroid.Conclusions and RelevanceAllergic rhinitis is associated with symptoms of nasal congestion, sneezing, and itching of the eyes, nose, and throat. Patients with allergic rhinitis should be instructed to avoid inciting allergens. Therapies include second-generation H1 antihistamines (eg, cetirizine, fexofenadine, desloratadine, loratadine), intranasal antihistamines (eg, azelastine, olopatadine), and intranasal corticosteroids (eg, fluticasone, triamcinolone, budesonide, mometasone) and should be selected based on the severity and frequency of symptoms and patient preference.
Enhanced Resolution, Throughput, and Stability of Aerosol Jet Printing via In Line Heating
Authors: Guyll Bella I. , Petersen Logan D. , Pint Cary L. , Secor Ethan B. 
Published: March 2024

AbstractAerosol jet printing offers high resolution, broad materials compatibility, and digital patterning for flexible, conformal, and hybrid electronics. However, limited throughput, instability, and complex optimization requirements inhibit translation to industrial applications. An in‐line heater integrated on a custom printer is demonstrated to modulate droplet evaporation in the aerosol phase, thereby decoupling the deposition rate of functional solids and liquid ink to enable taller, narrower features with aspect ratios reaching 0.29 for a single line. Heating the printhead from room temperature to 80 °C reduced the sensitivity of resolution to deposition rate by ≈90%, improving reliability. With this strategy, increasing the linear deposition rate by 10x results in a modest increase of 27% in line width, compared to a four‐fold increase without heating, permitting higher throughput without sacrificing print quality. Providing a control for in‐line drying independent of ink formulation enables rapid, straightforward design of new materials and processes. This ability to engineer drying of droplets prior to impingement provides a versatile tool to meet complex fabrication challenges, as demonstrated here for both high aspect ratio printing and conformal patterning on rough and three‐dimensional surfaces.
DBU‐Promoted [3+2] Cyclization/Retro‐Mannich Cascade Reaction of N‐Aminoisoquinolinium and N‐Aminoquinolinium Derivatives with para‐Quinone Methides
Authors: Ma Shaohong , Chen Mingyang , Yang Zifeng , Liu Xiang , Cao Hua 
Published: March 2024

AbstractA DBU‐promoted [3+2] cyclization/retro‐Mannich cascade reaction of N‐aminoisoquinolinium and N‐aminoquinolinium derivatives with para‐quinone methides has been established, employing a C=C double bond cleavage. A broad range of N‐aminoquinolinium salts, N‐aminoisoquinolinium salts, and para‐quinone methides are well tolerated, providing the corresponding rearrangement products. Moreover, scaled‐up reactions and diverse derivatizations of the products were also investigated and discussed.
The impact of the agricultural digital economy on China's agricultural export growth: Examining mechanisms from supply‐ and demand‐side path perspectives
Authors: Liu Yuchen , Dong Yinguo , Zhou Hui 
Published: March 2024

AbstractThe deep integration of the agricultural digital economy and foreign trade is an important driving force for promoting high–quality economic development. Based on a theoretical analysis of the impact mechanisms of the agricultural digital economy on agricultural exports, this study empirically examines the impact and mechanism of the agricultural digital economy on agricultural exports using Chinese agricultural export data from 2011 to 2016. The relevant findings are threefold. (1) The agricultural digital economy significantly enhances the growth of China's agricultural exports, and the result remains robust after a series of robustness tests. (2) The heterogeneity analysis reveals that the agricultural digital economy has a greater role in promoting exports from quality frontier firms, primary agricultural products and exports to developed countries. (3) The mechanism analysis demonstrates that the agricultural digital economy promotes exports of agricultural products on the supply side most strongly through quality–enhancing and the information cost effects, improving product quality and reducing information expenditure to achieve export growth. On the demand side, domestic demand traction and external–demand creation effects exert a local market effect and stimulate import market demand to promote export growth. [EconLit Citations: F746.12].
Transformational narrative changes as a community‐level approach to the prevention of adverse childhood experiences and substance use
Authors: Harper Christopher R. , Treves‐Kagan Sarah 
Published: March 2024

AbstractThere is increasing scientific evidence linking substance use, childhood adversity, and social determinants of health. However, little research has considered the evaluation of community‐level strategies to reduce substance use by increasing awareness and implementation of evidence‐based strategies for preventing adverse childhood experiences (ACEs). This article lays out the conceptual framework for a $2.9 million demonstration project designed to raise awareness of the impact of ACEs on substance use, including primary prevention strategies. Communities used transformational narrative change—with an emphasis on the voices of those most impacted by ACEs and substance use—to highlight the importance of addressing social determinants of health along with primary prevention strategies. The conceptual background highlighted in this article informed media, public health, and local efforts in the three accompanying articles and invited commentary. These findings may help inform future efforts to promote community‐level strategies and strengthen the evidence‐base for transformational narrative change efforts.
Chiral Canoe‐Like Pd0 or Pt0 Alloyed Copper Alkynyl Nanoclusters Display Near‐Infrared Luminescence
Authors: Fang Jun‐Jie , Liu Zheng , Wang Zhi‐Yi , Xie Yun‐Peng , Lu Xing 
Published: March 2024

AbstractAlloying nanoclusters (NCs) has emerged as a widely explored and versatile strategy for tailoring tunable properties, facilitating in‐depth atomic‐level investigations of structure‐property correlations. In this study, we have successfully synthesized six atomically precise copper NCs alloyed with Group 10 metals (Pd or Pt). Notably, the Pd0 or Pt0 atom situated at the center of the distorted hexagonal antiprism Pd0/Pt0@Cu12 cage, coordinated with twelve Cu+ and two tBuC≡C− ligands. Moreover, ligand exchange strategies demonstrated the potential for Cl− and Br− to replace one or two alkynyl ligands positioned at the top or side of the NCs. The chirality exhibited by these racemic NCs is primarily attributed to the involvement of halogens and a chiral (Pd/Pt)@Cu18 skeleton. Furthermore, all the NCs exhibit near‐infrared (NIR) luminescence, characterized by emission peaks at 705–755 nm, lifetimes ranging from 6.630 to 9.662 μs, and absolute photoluminescence quantum yields (PLQYs) of 1.75 %–2.52 % in their crystalline state. The experimental optical properties of these NCs are found to be in excellent agreement with the results of theoretical calculations. These alloy NCs not only offer valuable insights into the synthesis of Pd0/Pt0‐Cu alloy NCs, but also bridge the gap in understanding the structure‐luminescence relationships of Pd0/Pt0‐Cu molecules.
Dynamic Molecular Interphases Regulated by Trace Dual Electrolyte Additives for Ultralong‐Lifespan and Dendrite‐Free Zinc Metal Anode
Authors: Chen Hong‐Bo , Meng Huan , Zhang Tong‐Rui , Ran Qing , Liu Jie , Shi Hang , Han Gao‐Feng , Wang Tong‐Hui , Wen Zi , Lang Xing‐You , Jiang Qing 
Published: March 2024

AbstractMetallic zinc is a promising anode material for rechargeable aqueous multivalent metal‐ion batteries due to its high capacity and low cost. However, the practical use is always beset by severe dendrite growth and parasitic side reactions occurring at anode/electrolyte interface. Here we demonstrate dynamic molecular interphases caused by trace dual electrolyte additives of D‐mannose and sodium lignosulfonate for ultralong‐lifespan and dendrite‐free zinc anode. Triggered by plating and stripping electric fields, the D‐mannose and lignosulfonate species are alternately and reversibly (de‐)adsorbed on Zn metal, respectively, to accelerate Zn2+ transportation for uniform Zn nucleation and deposition and inhibit side reactions for high Coulombic efficiency. As a result, Zn anode in such dual‐additive electrolyte exhibits highly reversible and dendrite‐free Zn stripping/plating behaviors for >6400 hours at 1 mA cm−2, which enables long‐term cycling stability of Zn||ZnxMnO2 full cell for more than 2000 cycles.
More than just Alkene Construction – Re‐Using Wittig Reactions/Reagents in Biomacromolecular Labeling, Imaging, Sequencing and Modification
Authors: He Yin‐Ming , Cheng Liang 
Published: March 2024

AbstractClassical organic chemical reactions are essential for modern synthetic chemistry and offer valuable insights for chemical biology research. The pioneering bioorthogonal chemistry, based on the Staudinger reaction, is a prime example. However, the biocompatibility of classic “name” reactions like the Wittig reaction is still not fully explored. This versatile reaction efficiently converts carbonyl groups into olefins using phosphorus ylides, making it valuable in synthetic chemistry. Despite being in the early stages of development, the Wittig reaction and its reagents have various applications in peptide, protein, DNA, and RNA research. However, they have limitations such as low activity and efficiency, requiring organic solvents. Future directions may include developing Wittig reagents with improved biostability, simplifying the method, and creating multi‐labeling methods. Improving light‐activated Wittig reactions and interdisciplinary integration can further advance bioorthogonal chemistry. As technology advances, the Wittig reaction is poised to make greater contributions to molecular biology, cell biology, and biochemical modification research.
Synthesis and tensile properties of biomass‐based cis‐1,4‐polybutadiene using erythritol‐derived 1,3‐butadiene as a monomer
Authors: Toda Tomoyuki , Sasakawa Yuhi , Takenaka Katsuhiko , Yamaguchi Kosuke , Nakagawa Yoshinao , Nishii Kei , Nakamura Yo 
Published: March 2024

AbstractTransition metal–catalyzed polymerization of 1,3‐butadiene obtained from the erythritol, a kind of biomass product, was investigated to evaluate the effect of byproducts in the synthesis of 1,3‐butadiene from erythritol. Nuclear magnetic resonance spectroscopy and size exclusion chromatography results show that cis‐1,4‐polybutadiene can be selectively obtained using biomass 1,3‐butadiene model gas, which contains 1‐butene, cis‐2‐butene, and trans‐2‐butene, or erythritol‐derived 1,3‐butadiene, and no effect of butenes on the conversion rate or the microstructure of the resulting polymer was observed compared with using naphtha‐derived 1,3‐butadiene. The vulcanizate of the cis‐1,4‐polybutadiene obtained using 1,3‐butadiene having a biomass model gas containing butenes has mechanical properties equivalent to those of naphtha‐derived polybutadiene in tensile tests. This demonstrates that erythritol can be used as a new raw material for cis‐1,4‐polybutadiene.
Data‐centric species distribution modeling: Impacts of modeler decisions in a case study of invasive European frog‐bit
Authors: Hansen Sara E. , Monfils Michael J. , Hackett Rachel A. , Goebel Ryan T. , Monfils Anna K. 
Published: March 2024

AbstractPremiseSpecies distribution models (SDMs) are widely utilized to guide conservation decisions. The complexity of available data and SDM methodologies necessitates considerations of how data are chosen and processed for modeling to enhance model accuracy and support biological interpretations and ecological applications.MethodsWe built SDMs for the invasive aquatic plant European frog‐bit using aggregated and field data that span multiple scales, data sources, and data types. We tested how model results were affected by five modeler decision points: the exclusion of (1) missing and (2) correlated data and the (3) scale (large‐scale aggregated data or systematic field data), (4) source (specimens or observations), and (5) type (presence‐background or presence‐absence) of occurrence data.ResultsDecisions about the exclusion of missing and correlated data, as well as the scale and type of occurrence data, significantly affected metrics of model performance. The source and type of occurrence data led to differences in the importance of specific explanatory variables as drivers of species distribution and predicted probability of suitable habitat.DiscussionOur findings relative to European frog‐bit illustrate how specific data selection and processing decisions can influence the outcomes and interpretation of SDMs. Data‐centric protocols that incorporate data exploration into model building can help ensure models are reproducible and can be accurately interpreted in light of biological questions.