bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Anti-Gravity Treadmill Exercise After Total Knee Arthroplasty: Protocol for a Randomized Controlled Trial
Authors: Jääskeläinen Elina , Manninen Mikko , Hurri Heikki , Rantasalo Mikko , Zhou Yun , Kautiainen Hannu , Ristolainen Leena 
Published: February 2025

Background
Postoperative rehabilitation following total knee arthroplasty (TKA) varies worldwide. In Finland, patients receive guidance on safe walking and home exercises from a physiotherapist both before and after TKA. These are performed independently after surgery. However, a sedentary lifestyle is rather common among patients who have undergone TKA, with pain often limiting postoperative walking, training, and activities of daily living.

Objective
This randomized controlled trial aimed to investigate the effectiveness of anti-gravity exercise, precisely the AlterG anti-gravity treadmill, on postoperative rehabilitation following TKA and to obtain new knowledge on this form of rehabilitation to better use it in the future.

Methods
This randomized controlled trial study divided the patients into two groups: the intervention group and the control group. The follow-up period was 12 months. Research data were collected through questionnaires and functional tests. All patients in both groups responded to the questionnaires and participated in functional tests before surgery as well as 4 and 12 months after surgery. Patients in the intervention group exercised on the AlterG treadmill 10 times after the surgery. All the patients in this study performed the exercises as instructed when they were in the hospital. The primary outcomes were perceived pain, walking ability, and quality of life.

Results
The data collection process began in 2018 and concluded in 2022, intending to obtain valuable information regarding the effect of AlterG training after TKA and determine whether it, along with traditional exercises, could be an effective form of rehabilitation that can be performed at home. We hypothesized that AlterG training would lead to faster rehabilitation, better walking quality, improved quality of life, improved physical activity, and improved overall functioning. The results of this study will be analyzed in 2025 and 2026.

Conclusions
This study provides information on how AlterG training can be used in rehabilitation after TKA, further enhancing the rehabilitation program for patients undergoing TKA in general.

Trial Registration
ClinicalTrials.gov NCT03904030; https://clinicaltrials.gov/study/NCT03904030

International Registered Report Identifier (IRRID)
DERR1-10.2196/59935
Efficacy, Feasibility, and Acceptability of an Emotional Competence Tele-Intervention for Mandarin-Speaking Children Aged 5 to 7 Years With Developmental Language Disorder: Pilot Study With an Interrupted Time-Series Design
Authors: Lu Hsin-Hui , Liang Shih-Yuan , Huang Yi-Chia 
Published: February 2025

Background
Children with developmental language disorder (DLD) often experience language difficulties that hinder their ability to acquire emotional competence. Poor emotional competence is associated with emotional and behavioral problems in young children.

Objective
This research involved two studies focusing on (1) the emotional competence of Mandarin-speaking children aged 5 to 7 years with DLD and (2) the efficacy, feasibility, and acceptability of a tele-intervention designed to enhance their emotional competence in Taiwan.

Methods
Five children with DLD from study 1 declined to participate in study 2, the emotional competence tele-intervention, and were excluded from the analysis. We compared the emotional competence of 20 Mandarin-speaking children with DLD to that of 24 children with typical language development (TLD). The children with DLD were, on average, aged 5.79 (SD 0.47) years, whereas the children with TLD were, on average, aged 5.93 (SD 0.31) years. We assessed the children’s emotional competence, nonverbal ability, verbal comprehension, vocabulary acquisition, and expressive language skills. In study 2, all children with DLD included in study 1 engaged in an emotional competence tele-intervention. An interrupted time-series design was used to examine their emotional competence. In total, 20 children with DLD provided data on emotional competence evaluated using the Emotional Lexicon Test. These data were individually collected at 3 time points after study 1 (time 1). These phases included baseline (time 1 to time 2), during the tele-intervention (time 2 to time 3), and follow-up (time 3 to time 4), spanning approximately 18 to 20 weeks from time 1 to time 4. Recruitment, retention, and attendance rates were calculated to evaluate the intervention’s feasibility, and participant mood was evaluated after each session to calculate the intervention’s acceptability.

Results
No significant changes in the children’s ability to understand basic or complex emotional terms were observed during the baseline period. However, changes were observed during the tele-intervention period, and these changes remained throughout the follow-up period. With a recruitment rate of 80% (20/25), all participants completed 4 intervention sessions, with retention and attendance rates exceeding 95% (19/20). A total of 90% (18/20) of the participants deemed each session to be acceptable.

Conclusions
Mandarin-speaking children aged 5 to 7 years with DLD exhibited lower emotional competence compared with their counterparts with TLD. Tele-interventions are effective in enhancing the emotional competence of children with DLD, demonstrating feasibility and acceptability for these children and their parents in Taiwan.
Understanding the Impact of Diabetic Peripheral Neuropathy and Neuropathic Pain on Quality of Life and Mental Health in 6,960 People With Diabetes
Authors: Borbjerg Mette Krabsmark , Wegeberg Anne-Marie , Nikontovic Amar , Mørch Carsten Dahl , Arendt-Nielsen Lars , Ejskjaer Niels , Brock Christina , Vestergaard Peter , Røikjer Johan 
Published: February 2025

OBJECTIVE
Diabetic peripheral neuropathy (DPN) and neuropathic pain impacts quality of life (QoL) and mental health negatively. This cross-sectional survey study aimed to 1) elucidate the associations between painful and painless DPN and QoL, mental health, and socioeconomic factors, 2) assess the prevalence of sensory pain descriptors, and 3) evaluate the association between descriptors and the above factors.

RESEARCH DESIGN AND METHODS
Participants were grouped into people with (n = 1,601) and without (n = 5,359) DPN based on the Michigan Neuropathy Screening Instrument questionnaire. Participants with DPN were subsequently divided into people with (n = 1,085) and without (n = 516) concomitant neuropathic pain based on the modified Douleur Neuropathique en 4 Questions-interview.

RESULTS
The study showed diminished QoL (36-item Short Form Health Survey [SF-36]: 55.1 [interquartile range {IQR}36.7, 73.6], 82.2 [63.6, 90.9]) and poorer mental health (Hospital Anxiety and Depression Scale, subscale for anxiety: [HADS-A]: 5.00 [2, 9], 2.00 [1, 5]; HADS-subscale for depression [HADS-D]: 4.00 [1, 8], 1.00 [0, 3]) in participants with DPN compared with participants without DPN. The addition of pain diminished QoL (SF-36: 50.7 [34.8, 69.8]) and mental health (HADS-A: 6 [3, 10], HADS-D: 4 [1, 8]) further. The most prevalent pain descriptor in participants with painful DPN were burning pain (73%), while the most prevalent sensory descriptor was pins-and-needles (93%). An interesting finding is the high prevalence of itch (44%). Weak associations with mental health and QoL were present for cold pain, electric pain, and itch.

CONCLUSIONS
An increased focus on differences in QoL, mental health, and pain phenotypes is of importance to move the field forward toward more interdisciplinary, personalized treatment.
Circulating tumor DNA for surveillance in high-risk melanoma patients: a study protocol
Authors: Obinah Magnús P.B. , Al-Halafi Sarah A. , Dreisig Karin , Poulsen Tim S. , Johansen Christoffer , Litman Thomas , Bojesen Stig E. , Høgdall Estrid , Chakera Annette H. , Hölmich Lisbet R. 
Published: February 2025

Background and purpose: Melanoma is one of the deadliest skin cancers and challenges clinicians worldwide due to rising incidence, potential aggressiveness, and propensity for metastasis, necessitating comprehensive follow-up programs after primary treatment.
Circulating tumor DNA (ctDNA) is a promising biomarker that may indicate disease progression earlier than traditional surveillance methods, including 18F-FDG PET-CT, ultrasound, and clinical examination. This study examines ctDNA detection in blood as a minimally invasive method for early identification of progression following primary treatment of melanoma. The aim is to overcome the limitations of current methods, potentially improving prognosis and survival.
Patients/material and methods: Patients with high risk of recurrence following primary treatment of melanoma are offered inclusion. Blood sampling is performed at each follow-up visit. In case of recurrence, patient-specific mutations are identified through next-generation sequencing (NGS) of formalin and paraffin embedded tissue from diagnostic routine. Detection of mutation-specific ctDNA is performed on blood using digital droplet polymerase chain reaction (ddPCR) or NGS. This allows determination of the value and sensitivity of ctDNA for early detection of recurrence.
Results and Interpretation: For validation purposes, we conducted a small pilot study using blood samples from 10 patients who had experienced recurrence and had a clinically confirmed BRAF V600E mutation. Detection of BRAF V600E ctDNA using ddPCR varied from 0/5 (0%) in DNA harvested from 4 mL plasma, to 3/5 (60%) in DNA from 8 mL of plasma. These results show promise and highlight the importance of high sensitivity and sampling volumes to ensure accurate detection of low levels of ctDNA.
Pengaruh Penggunaan Abu Sekam dan Macam Pupuk Majemuk Terhadap Pertumbuhan dan Hasil Tanaman Tomat (Lycopersicum esculentum Mill)
Authors: Nidhar Adien Naufal Abyan , Rusmarini Umi Kusumastuti , Ardiani Fani 
Published: February 2025

Kebutuhan pangan nasional menumpukan harapan pada sektor pertanian, produksi tomat di Indonesia masihlah rendah bila dibandingkan negara lain. Tujuan dari penelitian ini adalah untuk mengetahui dampak pemanfaatan abu sekam dan macam pupuk majemuk kepada pertumbuhan juga hasil tanaman tomat. Studi ini dijalankan pada KP2 INSTIPER Maguwoharjo, Daerah Istimewa Yogyakarta, pada bulan April-Juli 2023. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) yang tersusun dari 2 faktor. Faktor pertama yaitu dosis abu sekam yang terdiri dari 3 aras, yaitu: 50g/polybag (kontrol), 60g/polybag, 70g/polybag, faktor kedua yaitu macam pupuk majemuk yang terdiri dari 3 macam yaitu; NPK15:15:15, NPK16:16:16, dan NPK9:25:25 dengan dosis 10g/tanaman. Berdasarkan kedua faktor didapatkan 9 kombinasi perlakuan, masing-masing diulang 3 kali jadi, ada 27 tanaman percobaan. Data hasil penelitian dianalisis memanfaatkan sidik ragam dengan jenjang nyata 5%. Hasil analisis memperlihatkan ada interaksi antara abusekam dan pupuk majemuk pada parameter diameter buah, rata-rata berat buah, berat segar tajuk, dan berat segar akar. Pemberian abu sekam dengan dosis 60g dan NPK 15:15:15 memberikan diameter buah 46,33 mm. Pemberian Abu sekam 70g berpengaruh baik kepada pertumbuhan tanaman, jumlah buah, juga berat buah/tanaman. Pemberian pupuk majemuk NPK16:16:16 memberikan pengaruh baik pada pertumbuhan tanaman, jumlah buah, juga berat buah/tanaman.
Analisis Faktor Kondisi Pembibitan Terhadap Serangan Penyakit Bercak Daun yang Disebabkan oleh Curvularia sp. pada Pembibitan Kelapa Sawit
Authors: Cameron Rizky Randal , Yusticia Stenia Ruski , Febriani Astri 
Published: February 2025

Penyakit bercak daun yang disebabkan oleh patogen Curvularia sp. dapat menyebabkan persentase serangan hingga 93,29% dan intensitas serangan sebesar 47,13%. Banyak faktor yang menyebabkan pesatnya perkembangan penyakit ini, antara lain kondisi tempat penyemaian, gulma, sertifikasi pembibitan, teknik pengendalian, lokasi pembibitan dll. Penelitian ini bertujuan untuk menganalisis faktor di pembibitan yang menyebabkan tingginya serangan penyakit bercak daun. Metode survei yang digunakan dalam penelitian ini adalah purposive sampling dengan mengambil sampel >80 bibit pada setiap lokasi pembibitan. Lokasi pembibitan yang diambil sampel sebanyak 9 lokasi pembibitan kelapa sawit. Data dianalisis dengan menggunakan uji T (perbandingan populasi) pada setiap faktor pendukung perkembangan penyakit. Hasil penelitian menunjukan terjadi perbedaan yang signifikan pada persentase dan intensitas serangan penyakit pada faktor tempat penyemaian kelapa sawit, lokasi pembibitan kelapa sawit, keberadaan gulma di pembibitan kelapa sawit, sertifikasi pembibitan kelapa sawit, dan jenis bibit kelapa sawit. Namun pada intensitas serangan bercak daun pada jenis bibit kelapa sawit menunjukan tidak berbeda secara signifikan.
PENGELOLAAN AIR BUANGAN AC SECARA INTEGRAL UNTUK MENGURANGI ANGGARAN BELANJA BAHAN PRAKTEK DAN KEPERLUAN AKADEMIK
Authors: Subandi Subandi 
Published: February 2025

Pondok Air limbah buangan AC merupakan hasil dari proses pengembunan memiliki sifat fisik dan kimia yang hampir sama dengan aquades, hasil penelitian terdahulu diperoleh data Pengukuran pH Aquadest 6.87, Air AC 6.63, Pengujian Kualitatif Mineral Aquadest Jernih, Air Ac Jernih, Air Kran Putih / Keruh, Pengujian Absorbansi Akuades 0.001, Air AC 0.006, Air Kran 0.374 dengan demikian air buangan AC yang dikelola sedemikian rupa bisa dimanfaatkan sebagai pengganti aquadest untuk kebutuhan praktikum dan perawatan alat lab.Pembuangan limbah AC selama ini belum mendapat perhatian yang baik, sehingga sering terjadi genangan dibeberapa tempat, tumbuh lumut pada dinding gedung dan menyebabkan pelapukan pada kusen jendela ruangan sehingga menimbulkan pemandangan yang tidak baik. Jumlah laboratorium yang berada di Polinela sebanyak 10 laboratorium, masing-masing laboratorium setiap hari memerlukan aquadest sebanyak 40 liter jadi total kebutuhan aquades sebanyak 400 liter. Harga aquades di pasaran perliter Rp 6.000,- dengan demikian Polinela setiap hari memerlukan biaya Rp. 6.000 X 400 liter = Rp. 2.400.000 untuk kebutuhan praktikum dan perawatan alat lab. Apabila air buangan AC yang berada di Polinela dikelola dengan baik secara seksama maka bisa dimanfaatkan untuk keperlua bahan praktek, penelitian mahasiswa dan dosen serta dimanfaatkan untuk beberapa keperluan lainnya, sehingga bisa mengurangi anggran belanja bahan praktek dan keperluan akademik lainnya.
Efficacy of non-cultured non-trypsinized dermabraded epidermal cell graft followed by narrowband ultraviolet B phototherapy in stable vitiligo
Authors: Chugh Dhriti , Kolalapudi Seetharam Anjaneyulu , Praveen Seva , Konala Subhashini , Swetha Narreddy Sai , Reddy Mareddy Koushik 
Published: February 2025

Objectives:
The objective of this study was to evaluate the efficacy and adverse effects of non-cultured, nontrypsinized dermabraded epidermal cell graft followed by narrowband ultraviolet B (NB-UVB) therapy for stable vitiligo.

Material and Methods:
A hospital-based and prospective interventional study was carried out on 45 patients (18–65 years) of both genders after approval from the Ethics Committee. The donor site was dermabraded after applying mupirocin ointment, and the material obtained was spread over the dermabraded recipient site. NBUVB phototherapy was initiated 3 weeks after the procedure and given for 3 months. Photographs were taken before the procedure and at the end of 3rd month of phototherapy and assessed for extent, pattern, and color matching of repigmented area according to physician global assessment (PGA) score and patient satisfaction score (PSS). Dermoscopic improvement was also noted.

Results:
Forty-five patients were enrolled in the study, out of which 43 patients completed the study. According to the intention to treat analysis, results were calculated in all 45 patients. Good to excellent response (50–100% improvement) was seen in 46.7% of patients according to the PGA score and in 57.8% of patients according to PSS. Most patients achieved the same color match with their normal skin at the end of the follow-up (73.3%). The most common repigmentation pattern was diffuse (46.7%), both clinically and dermoscopically. Among the clinical types, vitiligo vulgaris showed the maximum good to excellent repigmentation (61.3% and 77.4% of patients with PGA scores and PSS, respectively). Adverse effects were erythema, infection, and post-inflammatory hyper-pigmentation at the donor and recipient sites, whereas scarring was seen at the recipient site.

Conclusion:
It is a safe, simplified, cost-effective, and less time-consuming technique than earlier techniques and provides good to excellent repigmentation in a considerable proportion of participants.
ОСОБЕННОСТИ ПРИМЕНЕНИЯ ДАННЫХ С МОБИЛЬНЫХ ГНСС-УСТРОЙСТВ ДЛЯ ЦЕЛЕЙ ИНВЕНТАРИЗАЦИИ ЗЕМЕЛЬ
Authors: Шевчук А.А. , Костеша В.А. , Бирюков Д.А. , Митрофанов С.В. , Крылова А.Д. , Шуравина К.А. 
Published: February 2025

Современные требования к точности и оперативности геодезических и землеустроительных работ существенно возросли из-за необходимости эффективного управления земельными ресурсами и мониторинга их использования. Высокая стоимость традиционного ГНСС-оборудования вызывает потребность в доступных альтернативах, обеспечивающих необходимую точность. В этом контексте актуально использование мобильных ГНСС-устройств для инвентаризации земель сельскохозяйственного назначения. Цель исследования - оценка точности статического позиционирования с использованием СГНСС. Исследование направлено на определение пригодности данных для инвентаризации и мониторинга земель с/х назначения. Методы исследования включали полевые измерения с использованием мобильных устройств, оснащенных ГНСС-модулями, на НУБ «Чкаловская». Измерения проводились на разных расстояниях от базовой станции и с различной продолжительностью наблюдений. Данные обрабатывались с использованием специализированного ПО для геопространственного анализа, что позволило оценить точность измерений и рассчитать СКП. Результаты показали, что СГНСС обеспечивают необходимую точность измерений для задач инвентаризации с/х участков при наблюдениях от 30 до 60 минут. Эти устройства представляют собой экономически эффективную альтернативу традиционным методам.
Modern requirements for the accuracy and efficiency of geodetic and land surveying work have significantly increased due to the need for effective land resource management and monitoring. The high cost of traditional GNSS equipment necessitates affordable alternatives that provide the required accuracy. In this context, the use of mobile GNSS devices for the inventory of agricultural lands is relevant. The aim of the study is to assess the accuracy of static positioning using GNSS. The research focuses on determining the suitability of the data for inventory and monitoring of agricultural lands. The research methods included field measurements using mobile devices equipped with GNSS modules at the “Chkalovskaya” educational and research farm. Measurements were taken at different distances from the base station and with varying observation durations. The data was processed using specialized geospatial analysis software to evaluate measurement accuracy and calculate the RMSE. Results showed that GNSS provides the necessary measurement accuracy for agricultural land inventory tasks with observations ranging from 30 to 60 minutes. These devices represent a cost-effective alternative to traditional methods.
ПРИМЕНЕНИЕ ГИБРИДНЫХ ЭНЕРГЕТИЧЕСКИХ СИСТЕМ В СЕЛЬСКОХОЗЯЙТВЕННОМ КОМПЛЕКСЕ В РЕСПУБЛИКЕ САХА (ЯКУТИЯ)
Authors: Аль-Хусбан Я.Ю. , Эзирбаев Т.Б. 
Published: February 2025

Актуальность. На сегодняшний день интерес к разработке сельскохозяйственных и животноводческих проектов с использованием автономных возобновляемых технологий генерации электроэнергии все больше растет. Особенно данное направление становится актуальным с развитием сельского хозяйства и роста потребления электроэнергии в отдаленных районах крайнего севера. Одним из самых продвинутых регионов в плане внедрения на отдельных объектах возобновляемых источников энергии стала Якутия. Цель работы. Централизованным энергоснабжением в Якутии охвачено 40% территории, на которой проживает 90% населения республики, на остальной части республики действует локальная энергетика, в основном дизельная. Стоимость дизельного топлива возрастает ежегодно и сегодня перешагнула за 60 тыс. руб. за тонну. Как следствие - рост себестоимости производимой электроэнергии, которая на ряде станций достигает 100 рублей и выше за киловатт-час. Цель данной работы привести полученные авторами результаты изучения климата Республики Саха-Якутия по среднегодовой интенсивности солнечной радиации, среднегодовой скорости ветра, среднегодовой температуре и среднегодовому количеству солнечных часов и обосновать преимущество альтернативных источников и производства электрической и тепловой энергии с использованием инновационных гибридных солнечных технологий, ветроэнергетики и биоэнергетики на примере конкретного объекта. Результаты работы и обсуждение. В статье изучены новые технологии гибридных энергетических систем, приводится обоснование экономической устойчивости использования этих систем на современном и инновационном животноводческом проекте с автономным возобновляемым источником энергии.
At present there is a great interest in the development of agricultural and livestock projects using modern technologies of electric power gyneration, Yakutia has become one of the most advanced regions in terms of RES development. The cost of diesel fuel is increasing annually and today has crossed 60 thousand rubles per tonne. As a consequence, the cost of electricity produced, which at a number of stations reaches 100 rubles and more per kilowatt-hour. In this research work the climate of the Sakha-Yakutia Region is studied by the average annual intensity of solar radiation, average annual wind speed, average annual temperature and average annual number of sunny hours. It has become clear that there is an advantage in finding alternative solutions for sources and production of electrical and thermal energy using innovative hybrid solar, wind and bioenergy technologies. This paper will explore new technologies, economic implications and sustainability of using these systems on a modern and innovative livestock project with an off-grid renewable energy source.
Нематериальное культурное наследие — современные вызовы для академической науки и общественной практики
Authors: Лю К. 
Published: February 2025

Статья рассматривает аспекты работы по сохранению нематериального культурного наследия в научной и общественной сферах Китая, акцентируя внимание на изменении парадигмы восприятия самого понятия "нематериальное культурное наследие".
The article examines aspects of the work on the preservation of intangible cultural heritage in the scientific and public spheres of China, focusing on the paradigm shift in the perception of the very concept of "intangible cultural heritage".