bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bright light therapy versus physical exercise to prevent co-occurring depression in adolescents and young adults with attention-deficit/hyperactivity disorder: a multicentre, three-arm, randomised controlled, pilot phase-IIa trial
Authors: Mayer Jutta S. , Kohlhas Laura , Stermann Jacek , Medda Juliane , Brandt Geva A. , Grimm Oliver , Pawley Adam D. , Asherson Philip , Sanchez Judit Palacio , Richarte Vanesa , Bergsma Douwe , Koch Elena D. , Muntaner-Mas Adrià , Ebner-Priemer Ulrich W. , Kieser Meinhard , Retz Wolfgang , Ortega Francisco B. , Colla Michael , Buitelaar Jan K. , Kuntsi Jonna , Ramos-Quiroga Josep A. , Reif Andreas , Freitag Christine M. 
Published: April 2024

Abstract
Depression is common in attention-deficit/hyperactivity disorder (ADHD), but preventive behavioural interventions are lacking. This randomised controlled, pilot phase-IIa trial aimed to study a physical exercise intervention (EI) and bright light therapy (BLT)—both implemented and monitored in an individual, naturalistic setting via a mobile health (m-health) system—for feasibility of trial design and interventions, and to estimate their effects on depressive symptoms in young people with ADHD. Two hundred seven participants aged 14–45 years were randomised to 10-week add-on intervention of either BLT (10,000 lx; daily 30-min sessions) (n = 70), EI (aerobic and muscle-strengthening activities 3 days/ week) (n = 69), or treatment-as-usual (TAU) (n = 68), of whom 165 (80%) were retained (BLT: n = 54; EI: n = 52; TAU: n = 59). Intervention adherence (i.e. ≥ 80% completed sessions) was very low for both BLT (n = 13, 22%) and EI (n = 4, 7%). Usability of the m-health system to conduct interventions was limited as indicated by objective and subjective data. Safety was high and comparable between groups. Changes in depressive symptoms (assessed via observer-blind ratings, Inventory of Depressive Symptomatology) between baseline and end of intervention were small (BLT: −0.124 [95% CI: −2.219, 1.971], EI: −2.646 [95% CI: −4.777, −0.515], TAU: −1.428 [95% CI: −3.381, 0.526]) with no group differences [F(2,153) = 1.45, p = 0.2384]. These findings suggest that the m-health approach did not achieve feasibility of EI and BLT in young people with ADHD. Prior to designing efficacy studies, strategies how to achieve high intervention adherence should be specifically investigated in this patient group.

Trial registration
ClinicalTrials.gov, NCT03371810, 13 December 2017.
A review of multi-disciplinary decomposition research and key drivers of variation in decay
Authors: McIntyre Donna B. , Dawson Blake M. , Long Benjamin M. , Barton Philip S. 
Published: April 2024

AbstractThe decomposition of animal remains is a multifaceted process, involving ecological, biological, and chemical interactions. While the complexity is acknowledged through concepts like the necrobiome, it’s unclear if this complexity is reflected in research. Appreciation of the complexity of decomposition is crucial for identifying sources of variation in estimations of time since death in medico-legal science, as well as building broader ecological knowledge of the decomposition process. To gain insights into the extent of multidisciplinary research in the field of decomposition science, we conducted an examination of peer-reviewed literature on four key drivers of variation: volatile organic compounds, microbes, drugs/toxins, and insects. Among 650 articles, we identified their scientific discipline, driver/s of variation investigated, and year of publication. We found that 19% explored relationships between two drivers, while only 4% investigated interactions between three. None considered all four drivers. Over the past three decades, there has been a steady increase in decomposition research publications, signifying its growing importance. Most research (79%) was linked to forensic science, highlighting opportunities for interdisciplinary collaboration in decomposition science. Overall, our review underscores the need to incorporate multidisciplinary approaches and theory into contemporary decomposition research.
Exploring cranial macromorphoscopic variation and classification accuracy in a South African sample
Authors: Liebenberg Leandi , L’Abbé Ericka N. , Stull Kyra E. 
Published: April 2024

AbstractTo date South African forensic anthropologists are only able to successfully apply a metric approach to estimate population affinity when constructing a biological profile from skeletal remains. While a non-metric, or macromorphoscopic approach exists, limited research has been conducted to explore its use in a South African population. This study aimed to explore 17 cranial macromorphoscopic traits to develop improved methodology for the estimation of population affinity among black, white and coloured South Africans and for the method to be compliant with standards of best practice. The trait frequency distributions revealed substantial group variation and overlap, and not a single trait can be considered characteristic of any one population group. Kruskal-Wallis and Dunn’s tests demonstrated significant population differences for 13 of the 17 traits. Random forest modelling was used to develop classification models to assess the reliability and accuracy of the traits in identifying population affinity. Overall, the model including all traits obtained a classification accuracy of 79% when assessing population affinity, which is comparable to current craniometric methods. The variable importance indicates that all the traits contributed some information to the model, with the inferior nasal margin, nasal bone contour, and nasal aperture shape ranked the most useful for classification. Thus, this study validates the use of macromorphoscopic traits in a South African sample, and the population-specific data from this study can potentially be incorporated into forensic casework and skeletal analyses in South Africa to improve population affinity estimates.
Clinical trial evidence of quality-of-life effects of disease-modifying therapies for multiple sclerosis: a systematic analysis
Authors: Hirt Julian , Dembowska Kinga , Woelfle Tim , Axfors Cathrine , Granziera Cristina , Kuhle Jens , Kappos Ludwig , Hemkens Lars G. , Janiaud Perrine 
Published: April 2024

Abstract
Background
Increasingly, patients, clinicians, and regulators call for more evidence on the impact of innovative medicines on quality of life (QoL). We assessed the effects of disease-modifying therapies (DMTs) on QoL in people with multiple sclerosis (PwMS).

Methods
Randomized trials assessing approved DMTs in PwMS with results for at least one outcome referred to as “quality of life” were searched in PubMed and ClinicalTrials.gov.

Results
We identified 38 trials published between 1999 and 2023 with a median of 531 participants (interquartile range (IQR) 202 to 941; total 23,225). The evaluated DMTs were mostly interferon-beta (n = 10; 26%), fingolimod (n = 7; 18%), natalizumab (n = 5; 13%), and glatiramer acetate (n = 4; 11%). The 38 trials used 18 different QoL instruments, with up to 11 QoL subscale measures per trial (median 2; IQR 1–3). QoL was never the single primary outcome. We identified quantitative QoL results in 24 trials (63%), and narrative statements in 15 trials (39%). In 16 trials (42%), at least one of the multiple QoL results was statistically significant. The effect sizes of the significant quantitative QoL results were large (median Cohen’s d 1.02; IQR 0.3–1.7; median Hedges’ g 1.01; IQR 0.3–1.69) and ranged between d 0.14 and 2.91.

Conclusions
Certain DMTs have the potential to positively impact QoL of PwMS, and the assessment and reporting of QoL is suboptimal with a multitude of diverse instruments being used. There is an urgent need that design and reporting of clinical trials reflect the critical importance of QoL for PwMS.
Temporal tracking of cysteine 34 oxidation of plasma albumin as a biomarker of muscle damage following a bout of eccentric exercise
Authors: James Christopher , Dugan Cory W. , Boyd Corrin , Fournier Paul A. , Arthur Peter G. 
Published: April 2024

Abstract
Purpose
Exercise-induced muscle damage (EIMD) results in the generation of reactive oxygen species (ROS), but little is known about the temporal profile of change in ROS post-EIMD and how ROS levels relate to the onset of and recovery from EIMD. Our primary aim was to examine the effect of EIMD on the pattern of change in the blood level of thiol-oxidised albumin, a marker of oxidative stress.

Methods
Seven male participants were subjected on separate days to eccentric muscle contraction to cause EIMD or a no-exercise condition. After each session, the participants collected daily dried blood spots to measure thiol-oxidised albumin and returned to the laboratory every 2 days for the assessment of indirect markers of EIMD, namely maximal voluntary contraction (MVC), delayed onset muscle soreness (DOMS), creatine kinase (CK), and myoglobin.

Results
Eccentric exercise resulted in a significant decrease in MVC and increase in DOMS, CK, myoglobin, and thiol-oxidised albumin with the latter reaching above baseline level within 24–48 h post-exercise. All the markers of EIMD returned to baseline level within 6 days post-exercise, but not the level of thiol-oxidised albumin which remained elevated for 10 days after exercise. There was a moderate correlation between changes in thiol-oxidised albumin and DOMS, but no significant relationship between any other markers of muscle damage.

Conclusion
The levels of thiol-oxidised albumin increase in response to EIMD and remain elevated for several days post-exercise. The temporal pattern of change in the level of thiol-oxidised albumin suggests that this may be a useful biomarker of muscle repair post-EIMD.
The degeneration of locus coeruleus occurring during Alzheimer’s disease clinical progression: a neuroimaging follow-up investigation
Authors: Galgani Alessandro , Lombardo Francesco , Frijia Francesca , Martini Nicola , Tognoni Gloria , Pavese Nicola , Giorgi Filippo Sean 
Published: April 2024

AbstractThe noradrenergic nucleus Locus Coeruleus (LC) is precociously involved in Alzheimer’s Disease (AD) pathology, and its degeneration progresses during the course of the disease. Using Magnetic Resonance Imaging (MRI), researchers showed also in vivo in patients the disruption of LC, which can be observed both in Mild Cognitively Impaired individuals and AD demented patients. In this study, we report the results of a follow-up neuroradiological assessment, in which we evaluated the LC degeneration overtime in a group of cognitively impaired patients, submitted to MRI both at baseline and at the end of a 2.5-year follow-up. We found that a progressive LC disruption can be observed also in vivo, involving the entire nucleus and associated with clinical diagnosis. Our findings parallel neuropathological ones, which showed a continuous increase of neuronal death and volumetric atrophy within the LC with the progression of Braak’s stages for neurofibrillary pathology. This supports the reliability of MRI as a tool for exploring the integrity of the central noradrenergic system in neurodegenerative disorders.
European expert guidance on management of sleep onset insomnia and melatonin use in typically developing children
Authors: Bruni Oliviero , Breda Maria , Nobili Lino , Fietze Ingo , Capdevila Oscar Ramon Sans , Gronfier Claude 
Published: April 2024

AbstractSleeping problems are prevalent among children and adolescents, often leading to frequent consultations with pediatricians. While cognitive-behavioral therapy has shown effectiveness, especially in the short term, there is a lack of globally endorsed guidelines for the use of pharmaceuticals or over-the-counter remedies in managing sleep onset insomnia. An expert panel of pediatric sleep specialists and chronobiologists met in October 2023 to develop practical recommendations for pediatricians on the management of sleep onset insomnia in typically developing children. When sleep onset insomnia is present in otherwise healthy children, the management should follow a stepwise approach. Practical sleep hygiene indications and adaptive bedtime routine, followed by behavioral therapies, must be the first step. When these measures are not effective, low-dose melatonin, administered 30–60 min before bedtime, might be helpful in children over 2 years old. Melatonin use should be monitored by pediatricians to evaluate the efficacy as well as the presence of adverse effects. Conclusion: Low-dose melatonin is a useful strategy for managing sleep onset insomnia in healthy children who have not improved or have responded insufficiently to sleep hygiene and behavioral interventions.

What is Known:• Pediatric insomnia is a common disorder and impacts children's emotional, behavioral, and cognitive functioning, as well as parents' sleep and daytime functioning.• There is no consensus in Europe on the management of sleep onset insomnia and the use of melatonin in typically developing children.

What is New:• A group of European experts has compiled a set of recommendations for the management of insomnia, developing a step-by-step approach.• Sleep hygiene, behavioral strategies, and finally low-dose melatonin represent valid strategies for managing sleep onset insomnia.
USP7 promotes cervical cancer progression by stabilizing MTDH expression through deubiquitination
Authors: Wang Na , Xu Jing , Wang Yujing , Zhang Xuejiao , Zhang Hongzhen 
Published: April 2024

Abstract
Background
Metadherin (MTDH) and ubiquitin specific protease 7 (USP7) have been identified to involve in the tumorigenesis of cervical cancer (CC). USP7 is one of the deubiquitinating enzymes. Here, this study aimed to explore whether USP7 affected CC progression via interacting with MTDH and regulating its stability via deubiquitination.

Methods
qRT-PCR and western blotting assays detected the levels of genes and proteins. Functional analysis was conducted using 5-ethynyl-2’-deoxyuridine (EdU), flow cytometry, transwell, and tube formation assays, respectively. Proteins between USP7 and MTDH were identified by co-immunoprecipitation assay. A mouse xenograft model was established for in vivo analysis.

Results
MTDH was highly expressed in CC tissues and cells, silencing of MTDH suppressed CC cell proliferation, migration, invasion, angiogenesis, and macrophage M2 polarization. Mechanistically, USP7 directly bound to MTDH, and maintained its stability by removing ubiquitination on MTDH. CC tissues and cells showed high USP7 expression, and USP7 knockdown also inhibited CC cell proliferation, migration, invasion, angiogenesis and macrophage M2 polarization, and these effects mediated by USP7 knockdown were reversed by MTDH overexpression. Moreover, USP7 knockdown impeded CC growth in vivo by regulating MTDH.

Conclusion
Collectively, USP7 promoted CC cell proliferation, migration, invasion, angiogenesis, and macrophage M2 polarization in vitro, as well as tumor growth in vivo by regulating MTDH.
Identification and validation of a lactate metabolism-related six-gene prognostic signature in intrahepatic cholangiocarcinoma
Authors: Sang Chen , Yan Li , Lin Jian , Lin Youpei , Gao Qiang , Shen Xia 
Published: April 2024

Abstract
Purpose
Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant and fatal liver tumor with increasing incidence worldwide. Lactate metabolism has been recently reported as a crucial contributor to tumor progression and immune regulation in the tumor microenvironment. However, it remains poorly identified about the biological functions of lactate metabolism in iCCA, which hinders the development of prognostic tools and therapeutic interventions.

Methods
The univariate Cox regression analysis and Boruta algorithm were utilized to identify key lactate metabolism-related genes (LMRGs), and a prognostic signature was constructed based on LMRG scores. Genomic variations and immune cell infiltration were evaluated in the high and low LMRG score groups. Finally, the biological functions of key LMRGs were verified with in vitro and in vivo experiments.

Results
Patients in the high LMRG score group exhibit a poor prognosis compared to those in the low LMRG score group, with a high frequency of TP53 and KRAS mutations. Moreover, the infiltration and function of NK cells were compromised in the high LMRG score group, consistent with the results from two independent single-cell RNA sequencing datasets and immunohistochemistry of tissue microarrays. Experimental data revealed that lactate dehydrogenase A (LDHA) knockdown inhibited proliferation and migration in iCCA cell lines and tumor growth in immunocompetent mice.

Conclusion
Our study revealed the biological roles of LDHA in iCCA and developed a reliable lactate metabolism-related prognostic signature for iCCA, offering promising therapeutic targets for iCCA in the clinic.
Various optimized machine learning techniques to predict agricultural commodity prices
Authors: Sari Murat , Duran Serbay , Kutlu Huseyin , Guloglu Bulent , Atik Zehra 
Published: April 2024

AbstractRecent increases in global food demand have made this research and, therefore, the prediction of agricultural commodity prices, almost imperative. The aim of this paper is to build efficient artificial intelligence methods to effectively forecast commodity prices in light of these global events. Using three separate, well-structured models, the commodity prices of eleven major agricultural commodities that have recently caused crises around the world have been predicted. In achieving its objective, this paper proposes a novel forecasting model for agricultural commodity prices using the extreme learning machine technique optimized with the genetic algorithm. In predicting the eleven commodities, the proposed model, the extreme learning machine with the genetic algorithm, outperforms the model formed by the combination of long short-term memory with the genetic algorithm and the autoregressive integrated moving average model. Despite the fluctuations and changes in agricultural commodity prices in 2022, the extreme learning machine with the genetic algorithm model described in this study successfully predicts both qualitative and quantitative behavior in such a large number of commodities and over such a long period of time for the first time. It is expected that these predictions will provide benefits for the effective management, direction and, if necessary, restructuring of agricultural policies by providing food requirements that adapt to the dynamic structure of the countries.
Bioprospecting for plant resilience to climate change: mycorrhizal symbionts of European and American beachgrass (Ammophila arenaria and Ammophila breviligulata) from maritime sand dunes
Authors: Grassi Arianna , Pagliarani Irene , Avio Luciano , Cristani Caterina , Rossi Federico , Turrini Alessandra , Giovannetti Manuela , Agnolucci Monica 
Published: April 2024

AbstractClimate change and global warming have contributed to increase terrestrial drought, causing negative impacts on agricultural production. Drought stress may be addressed using novel agronomic practices and beneficial soil microorganisms, such as arbuscular mycorrhizal fungi (AMF), able to enhance plant use efficiency of soil resources and water and increase plant antioxidant defence systems. Specific traits functional to plant resilience improvement in dry conditions could have developed in AMF growing in association with xerophytic plants in maritime sand dunes, a drought-stressed and low-fertility environment. The most studied of such plants are European beachgrass (Ammophila arenaria Link), native to Europe and the Mediterranean basin, and American beachgrass (Ammophila breviligulata Fern.), found in North America. Given the critical role of AMF for the survival of these beachgrasses, knowledge of the composition of AMF communities colonizing their roots and rhizospheres and their distribution worldwide is fundamental for the location and isolation of native AMF as potential candidates to be tested for promoting crop growth and resilience under climate change. This review provides quantitative and qualitative data on the occurrence of AMF communities of A. arenaria and A. breviligulata growing in European, Mediterranean basin and North American maritime sand dunes, as detected by morphological studies, trap culture isolation and molecular methods, and reports on their symbiotic performance. Moreover, the review indicates the dominant AMF species associated with the two Ammophila species and the common species to be further studied to assess possible specific traits increasing their host plants resilience toward drought stress under climate change.
Ultrasound-based predictive indicators for treatment outcomes in pediatric vesicoureteral reflux
Authors: Öztürk Mehmet , Şen Haluk , Yılmaz Feyza , Bayrak Ömer , Demirci Gürdal , Baturu Muharrem , Erturhan M. Sakıp , Seçkiner İlker 
Published: April 2024

Abstract
Purpose
To evaluate the effectiveness of preoperative ultrasound (US) measurements in predicting pediatric vesicoureteral reflux (VUR) treatment outcomes.

Methods
This prospective study enrolled 35 patients (53 renal units) aged 1–16 years who underwent subureteric injection therapy for primary VUR between July 2020 and June 2022. Preoperative ultrasound examinations measured the bladder wall thickness at the ureteral orifice, ureteral submucosal tunnel length, distal ureteral diameter, patient demographics, VUR grade, presenting complaints, bladder–bowel dysfunction, and renal scarring, and the impact of these variables on treatment success was analyzed.

Results
Among the patients, 91.4% were female, with a mean age of 6.83 ± 3.84 years. A comparison between the treatment success and failure groups revealed no significant differences in the age, sex, VUR grade, laterality, bilaterality, presenting complaints, bladder–bowel dysfunction, bladder wall thickness, or distal ureteral diameter (p > 0.05). However, renal scarring occurred in 16 (38.1%) patients in the treatment success group and 10 (90.9%) in the treatment failure group (p = 0.002). The treatment failure group had shorter detrusor-to-ureteral orifice distances and smaller detrusor-ureteral orifice distance-to-distal ureteral diameter (D/U) ratios than that of the success group (p = 0.004 and p = 0.006, respectively). Patients with a detrusor-to-ureteral orifice distance < 7.4 mm had an 81.82% likelihood of treatment failure.

Conclusion
Ultrasound measurements of the detrusor-to-ureteral orifice distance and D/U ratio proved reliable in predicting the success of endoscopic subureteric injection therapy for VUR.
Digitalisierung in der Lehre der Neurologie und Psychiatrie
Authors: Altmann Patrick , Pezawas Lukas , Kasprian Gregor , Löffler-Stastka Henriette 
Published: April 2024

ZusammenfassungDigitalisierung in der Medizin gehört zur Zukunft der akademischen Medizin. Diesem Fakt wird auch in der Lehre Rechnung getragen. Da Lehre immer forschungsgeleitet gestaltet ist, sind auch die lerntheoretischen Grundlagen und Konzepte zu diskutieren. Die Implementierung digitaler Medizin stellt eine Möglichkeit als Brückenfunktion für eine gute interprofessionelle Zusammenarbeit dar. Diese Interprofessionalität erachten wir in unserem Fachgebiet als zentral, ebenso wie gutes Netzwerkmanagement. Die hier vorgestellten Anwendungen und deren Vermittlung im Unterricht führen in der interprofessionellen Arbeit zu einer Thematisierung von Denk- und Reflexionsprozessen, die eine bessere Arbeitszufriedenheit und Patient:innenzufriedenheit nach sich ziehen.