bluuebunny/crossref_metadata_2025_split huggingface dataset:
The first case of a peritoneal dialysis-associated peritonitis caused by Gordonia sputi in a child
Authors: Takagi Yuhi , Kano Yuji , Tarukawa Tomomi , Yoshihara Shigemi 
Published: March 2024

Abstract
A 1-year-and-3-month-old girl was admitted to our hospital after an initial episode of peritoneal dialysis-related peritonitis (PDRP) following a broken Tenckhoff catheter. On the 10th day of treatment, 16S rRNA gene sequencing of the patient’s isolates and comparative sequence identity analyses revealed the bacterium responsible for peritonitis as Gordonia sputi. An antimicrobial agent (ampicillin) was selected based on the minimum inhibitory concentration, and after a treatment course spanning 3 weeks, no recurrence was observed. PDRP caused by Gordonia species manifests sporadically after Tenckhoff catheter breakage. Further, PDRP caused by Gordonia species often recur, and the Tenckhoff catheter is removed. However, in many cases, the recurrence is due to a short duration of antimicrobial therapy. As already known, 16S rRNA gene sequencing is useful for diagnosing Gordonia species. Further studies are needed regarding the choice of antimicrobial agents and the duration of administration.
The enhancement effect of social interaction on emotional contagion: an EEG-based hyperscanning study
Authors: Wang Hui , Gao Xiaolan , Xu Chuyan , Chen Wenfeng 
Published: March 2024

Abstract
Emotional contagion refers to the tendency for individuals to replicate the emotional states of others primarily within the context of social interactions. Prior research has focused on real-time emotional contagion during interpersonal communication. However, this study proposed that social interaction experiences might also play a role in promoting emotional contagion. To investigate this issue, the present study divided participants into the interactive group and the control group and conducted EEG-based hyperscanning to investigate the impact of interpersonal interaction experience on emotional contagion. Behavioral results indicated that individuals reported a greater psychological closeness to their partners after experiencing interaction. Additionally, the interactive group showed stronger emotional congruence between observers and senders. EEG results further demonstrated that inter-brain synchrony in the emotional contagion phase among the observer and sender of the interactive group was significantly higher than that of the control group, particularly in the negative emotions. This research suggests that social interaction experience may affect emotional contagion by altering the interpersonal states. It also adds to our understanding of how social interactions can shape our emotional experiences and emphasizes that interpersonal experiences might be a key factor in promoting emotional contagion.
Lived Caregiving Experience of Foreign Domestic Workers (FDWs) for those with Terminal Illness in Singapore: A Secondary Qualitative Data Analysis
Authors: Lee Jing Yi , Liaw Karen , Lee Angel , Oh Hong Choon , Ng Foong Ling , Nurjono Milawaty 
Published: March 2024

Abstract
Background
Due to societal changes associated with evolving family structures in Singapore, the reliance on foreign domestic workers (FDWs) for elderly caregiving is increasing. While involving FDWs in caregiving has proven effective in moderating family caregivers' burden and benefiting patients' health outcomes, their caregiving experiences of FDWs are not always ideal. Existing studies on FDWs' caregiving experiences have mainly focused on elder care. However, palliative care, being more specialised and intense, poses unique challenges. Given high caregiver burden experienced in caring for non-cancer patients with terminal illnesses, this study aims to explore FDWs' experiences in caring for non-cancer patients at their end of lives in Singapore.
Method
A qualitative secondary analysis was conducted on 15 transcripts from a study related to a non-cancer palliative care program. The analysis used an adapted model combining the Informal Caregiving Integrative Model (ICIM), Inherent Tension of Caregiving Model, and Risk and Resistance Model (RRM) of Adjustment model. FDWs' experiences were categorized into five caregiving profiles based on perceived burden and benefits characterised by Pristavec.
Results
Based on caregiver experience profiling characteristics by Pristavec, one was classified under “intensive domestic helper”, while two others were classified as “relationship”. Nine had a “balanced” profile and three others were classified as “satisfied” FDWs. Common caregiver outcomes like psychological stress and physical fatigue were observed across different profiles. Each profile highlighted unique caregiving experiences, emphasizing the significance of individual coping strategies, clear personal boundaries, and positive mindsets in mitigating the impact of caregiving demands on FDWs' wellbeing.
Conclusion
This study provides valuable insights into FDWs' caregiving experiences of non-cancer patients with terminal illnesses. The findings suggest the need for tailored services or interventions to enhance FDWs' coping abilities. Future research could focus on developing caregiver support programs specifically designed for FDWs caring for individuals with terminal illnesses.
Investigating The Relationship Between The Mean Heart Doses Received In Left Breast Cancer Radiation Therapy With Pro-BNP And Troponin Values And Left Ventricular Systolic Function Based On Left Ventricle Ejection Fraction (LVEF) And Global Longitudinal Strain (GLS) Values In Echocardiography
Authors: Akhavan Ali , Rayegani Amirhosein , Alizadehasl Azin , Parhizgar Seyed Ehsan , Tajmirriahi Marzieh , Golchin Shadi , Roayaei Mahnaz , Abdollahpour Ibrahim 
Published: March 2024

Abstract
BACKGROUND: The purpose of this study is to investigate the relationship between the mean heart dose received in left breast cancer radiation therapy and cardiac injury as measured by Pro-BNP and Troponin laboratory levels and left ventricular systolic function, as measured by LVEF and GLS levels in echocardiography.
METHOD: This research was carried out at Omid Hospital, Isfahan City, Iran, using the before and after intervention study and single-arm approach on a population of patients diagnosed with cancer of the left breast who received radiation therapy for the left breast between 2021- 2022. Troponin, Pro-BNP, GLS, and LVEF were investigated before and after intervention. The data was analyzed using the t-test and the Mann-Whitney U test. Ultimately, it was examined using version 22 of the SPSS program.
RESULTS: This study showed a statistically significant difference in pro-BNP before and after the intervention (P<0.001). Also, we investigated the relationship between the mean heart dose, mean LAD dose, mean LV dose, radiotherapy protocol, and V25 index with the changes of Troponin, Pro-BNP, GLS, and LVEF, and we observed no statistically significant relationship between them (P>0.05).
CONCLUSION: Left breast radiation therapy does not affect cardiac factors like LVEF and troponin in the short term. Also, we observed Pro-BNP meaningful changes and the effect of V25 on GLS after the radiation. Studies with a larger sample size and a longer follow-up period are suggested.
Safety Evaluation of 177 Lu-TEFAPI-06 with Long-Term Blood Circulation in Rodents
Authors: Wang Liqin , He Chen , Cui Zhencun , Liu Jiangyan 
Published: March 2024

Abstract
Purpose
To evaluate the pharmacological and toxicological safety of TEFAPI-06 in rodents, offering crucial insights for its clinical trial applications.
Methods
For bistribution analysis, SD rats were divided into six groups to study the kinetics of 177Lu-TEFAPI-06 post intravenous administration. Rats were euthanized at predetermined time points (0.5h, 2h, 24h, 48h, 72h, 144h) for radioactivity measurements in blood and various organs. Additionally, tumor uptake in 177Lu-TEFAPI-06 treated mice was monitored using small animal in vivo imaging. For toxicological assessment, SD rats were assigned to high, medium, low-dose, and control groups. A single dose of TEFAPI-06 was administered via the tail vein. Observations included immediate and short-term physiological responses (up to 6h post-dosing), followed by twice-daily general health assessments. Blood samples were collected on days 3 and 15 for comprehensive analysis, including complete blood count, liver and kidney function, glucose and lipid levels, and histopathological evaluations.
Results
177Lu-TEFAPI-06 is mainly metabolized in the liver and excreted through the kidneys, showing effective tumor targeting and prolonging residence time. Post-dose observations showed no significant behavioral or respiratory changes in any of the groups. The body weight and blood biochemical indexes of routine blood parameters in all dose groups were statistically comparable with those in the control group (P > 0.05). Pathological examination revealed no obvious abnormalities.
Conclusion
TEFAPI-06 appears safe in SD rats following a single intravenous injection, with efficient tumor targeting and rapid metabolism in normal tissues. These findings support its potential for further clinical trial considerations.
A Novel Cross-layer Based Modified Support Vector Machine (E-svm) for Detecting Blackhole and Wormhole Attack in Wireless Ad-hoc Networks
Authors: Sriniva Jagadeesan 
Published: March 2024

Abstract
Wireless Ad-hoc Network do not require existing infrastructure .The devices generally that can exist are an access point that connects the end computing devices. Existing approaches suffer from challenges like low detection accuracy, low deviation structure and has more processing time. The paper provides a cross-layer approach by using physical and MAC layer knowledge of the wireless medium that is shared with the higher layer for handling the wormhole and black hole attack. The wormhole attack using tunneling whereas the black hole attack impersonates the source by changing the network traffic. The cross-layer capabilities are provided with three layers Network layer, MAC layer and physical layer and are independent of network protocols. The channel interference is handled by the physical layer, process handling by Network layer. Mac layer works with Network and physical layer by taking care of the Bandwidth information, Number of failed transmissions. The performance estimation for Time interval is in seconds. The proposed E-SVM Algorithm outperforms the SVM algorithm in terms of average consumed energy, average remaining energy, and packets received, packet delivery ratio, Delay, Jitter, Throughput, Normalized Overhead, Dropping ratio, Goodput. To do that E-SVM proposed and simulated in NS2.32 software and the results are demonstrated in terms of various qualities of service parameters and performance is evaluated.
Development and validation a prognostic score for TIPS placement in patients with viral hepatitis cirrhosis-related portal hypertension: a multi-center retrospective study
Authors: Que Zenglong , Wu Mingsong , Lai Shujie , Wang Lei , Mu Zhiyong , Yang Jinhui , Xiong Wei , Hu Hong , Liu Aimin , An xuan , Yu Haodong , Cao qin , Zhang yanmei , Luo wenwen , Wang jun , Chen Dongfeng , Liu Fuquan , Zhang dazhi , Wen Liangzhi 
Published: March 2024

Abstract

Objectives Noninvasive methods are effective and promising way to predict the prognosis after transjugular intrahepatic portosystemic shunt (TIPS). However, there is no established scoring model focus on viral hepatitis including hepatitis B virus (HBV) and hepatitis C virus (HCV) patients to predict the survival of post-TIPS. In this study, we aimed to firstly develop (8 centers in southwestern China) and external validate (1 center in northeastern China) a novel model based on the largest cohort for better prediction of both short-term (1 year) and long-term (3 years) postoperative prognosis after TIPS in viral hepatitis cirrhosis-related portal hypertension patients. Methods A total of 925 viral hepatitis cirrhosis-related portal hypertension patients undergoing TIPS from nine hospitals were divided into the training (8 centers in southwestern China) and external validation (1 center in northeastern China) cohorts. A novel Viral-associated Index of Post-TIPS score (VIPs) model was built after performing cox regression. To verify the performance of novel model, we compared it with five previous models including Child‒Pugh, MELD, ALBI, CCG and FIPS scores. Furthermore, Using X-tile software to stratify patients into low-medium-high risk groups. Results We developed a novel VIP score model including age, ascites, albumin, prothrombin time, total bilirubin, and sodium for post-TIPS prognosis prediction. The novel model demonstrated a satisfying predictive efficiency in both discrimination and calibration, with an area under the curve of 0.781/0.774 (1-year/3-year) in the training cohort and 0.771/0.775 (1-year/3-year) in the external validation cohort, respectively. Using X-tile software, two optimal cutoff values (83 and 115) were generated to divide the entire cohort into three risk groups with significant difference in post-TIPS prognosis: low risk (score < 83), medium risk (score 83–115), and high risk (score > 115). Conclusions We firstly developed and external validated a novel VIPs model for better prediction of both short-term (1 year) and long-term (3 years) postoperative prognosis after TIPS in Chinese patients with viral hepatitis cirrhosis-related portal hypertension.
Characteristics of soliton gas with the strongest pairwise soliton interactions in the focusing Gardner equation
Authors: Zhang Xuefeng , Xu Tao , Yang Yuxin , Li Min 
Published: March 2024

Abstract

For the focusing Gardner equation, we investigate the dynamics of soliton gas (SG) incorporating the strongest pairwise soliton interactions that achieve the maximum attainable amplification AI = 2. In our simulated SG, the interactions of positive solitons overtaking negative ones are dominant because the velocities of most of positive solitons are larger than those of negative ones in the initial distribution. As the number of bipolar soliton pairs with AI = 2 increases, the third moment decrease in absolute while the fourth moment increases. Meanwhile, the maximum values in the global wave field increase significantly while the minimum values exhibit a relatively modest increase, owing to the generation of many high positive transient waves during interactions, as compared to the limited production of high negative transient waves. Also, an obvious elevation in the tails of global probability density functions is observed for positive wave amplitudes, which indicates an increase of the number of extreme events in the wave field. In addition, the rogue wave (RW) occurrence probability does not increase but rather decreases, in contrast to the situation in the integrable turbulence. Our findings may be useful for realizing some controllable experiments of the SGs in water waves.
PACS: 05.45.Yv; 02.30.Ik; 47.35.Fg.
Impact of Dynamic Infection Rate and Self-Isolation Awareness onNetworked Epidemic Propagation
Authors: Yuan Xianglai , Yao Yichao , Li Xiangxi , Feng Minyu 
Published: March 2024

Abstract
In the past decades, numerous models have been proposed in epidemic modeling. However, few of them describe the dynamic variation process of the infection rates, and the impact of infected individuals' safety awareness on epidemic spreading has also been rarely studied. Therefore, we propose a novel epidemic spreading model with dynamic infection rates (DIR) and self-isolation awareness (SIA) in this paper. The DIR describes the variation in infection rates over time, and the SIA denotes the infected individuals' safety awareness. We suggest that both DIR and SIA can suppress the spread of the epidemic, and SIA has a greater impact on the peak infection and the time to peak infection compared with DIR, while DIR plays a critical role in eradicating the epidemic. Additionally, the higher the intensity of SIA, the lower the peak infection and the stationary infection density. As the intensity of SIA increases, its inhibitory effect on the peak infection exhibits a marginal effect. Furthermore, when considering different epidemic models with DIR and SIA, simulation results indicate that the infection density distribution is similar, but the corresponding infection density values vary significantly.
Sonoclot Versus conventional coagulation parameter for assessment of hemostasic abnormalities in children with β- Thalassemia: Egyptian center study
Authors: kamel Inas M , Youssef Mervat A. M. , El-Azeem Hanan G Abd , Zahran Asmaa M. , Elgammal Sahar A. , Abdelaal Azza 
Published: March 2024

Abstract
Background: This study assessed the efficiency of the Sonoclot analyzer and conventional hemostatic parameters in determining the hemostatic status of children with β-thalassemia Major (BTM) who had experienced bleeding or thromboembolic episodes in the past, as well as any potential underlying risk factors.
Methods: Prospective cross-sectional study on 98 children with BTM. Patients are classified into three groups according to the history; bleeders group, thrombotic group and non-complicated group . Coagulation screen, D-dimer, protein C (PC), antithrombin III, ferritin, platelet aggregation response to ADP and arachidonic acid (AA), Sonoclot analysis, CD41 and CD62p by flow cytometry were performed.
Results:
Five patients (4.9%) had thrombosis and 15(15.3%) had bleeding. Significant higher ferritin, and Clot Rate (CR) were found in thrombotic group compared to non-complicated (P=0.04) and bleeder (P= 0.01) groups.
Platelet Function was significantly lower in bleeders compared to non-complicated (P =0.00006) and thrombotic (P=0.002)groups. Protein C, PT, PC, APTT, fibrinogen, D-dimer, and ATIII, showed no significant difference between groups. Although, CD62p expression by flow cytometry showed no significant difference between groups. CR has shown a statistically significant negative correlation with PC and D-dimer. Also, significant positive correlation between platelet function by Sonoclot with ADP & AA by aggregometer.
Conclusion:
Sonoclot analysis may verify as an effective method for evaluating the hemostasis in children with BTM. CR and PF may become a possible future predictors of hyper and hypo -coagulability respectively. Traditional test of coagulation should be used in conjunction with the standard tests to define the hemostatic profile in those patient.
Trial registration
The study is approved by Assiut University's Ethical Committee of Faculty of Medicine (IRB No: 17200439)
Efficacy and Safety of Fentanyl Inhalant for the Treatment of Breakthrough Cancer Pain: A Multicenter, Randomized, Double- blind, Placebo-controlled Trial
Authors: Lin Rongbo , Song Binbin , Li Na , Rong Biaoxue , Bai Jinghui , Liu Yong , Wang Wei , Liu Anwen , Luo Suxia , Liu Bo , Wu Yani , Li Yujie , Yu Xiaohui , Liu Xueying , Dai Xiangrong , Li Xiaoyi , Liu Dongying , Wang Jian , Huang Yan 
Published: March 2024

Abstract

BackgroundBreakthrough cancer pain (BTcP) has a negative impact on patients’ quality of life, general activities, and is related to worse clinical outcomes. Fentanyl inhalant is a hand-held combination drug-device delivery system providing rapid, multi-dose (25μg/dose) administration of fentanyl via inhalation of a thermally generated aerosol. This multicenter, randomized, placebo-controlled, multiple-crossover, double-blind study evaluated the efficacy, safety, and tolerability of fentanyl inhalant in treating BTcP in opioid-tolerant patients.
Methods Each patient was treated and observed for 6 episodes of BTcP (4 with fentanyl inhalant, 2 with placebo). During each episode of targeted BTcP, patients were allowed up to six inhalations. Primary outcome was the time-weighted sum of PID (pain intensity difference) scores at 30 minutes (SPID30).
Results A total of 335 BTcP episodes in 59 patients were treated. The mean SPID30 was -97.4 ± 48.43 for fentanyl inhalant-treated episodes, and -64.6 ± 40.25 for placebo-treated episodes (p<0.001). Significant differences in PID for episodes treated with fentanyl inhalant versus placebo was seen as early as 4 minutes and maintained for up to 60 minutes. The percentage of episodes reported PI (pain intensity) scores ≤ 3, a ≥ 33% or ≥ 50% reduction in PI scores at 30 minutes, PR30 (pain relief scores at 30 minutes) and SPID60 favored fentanyl inhalant over placebo. Only 4.4% of BTcP episodes required rescue medication in fentanyl inhalant group. Most AEs were of mild or moderate severity and typical of opioid drugs.
Conclusion Fentanyl inhalant was efficacious, safe, and well tolerated in the management of BTcP.
Trial registration ClinicalTrials.gov: NCT05531422
Rural reality contradicts the ethnographic literature – a nationwide survey on folk beliefs and people's affection for the stork in Poland
Authors: Wuczyński Andrzej , Pieńczak Agnieszka , Krogulec Gabriela 
Published: March 2024

Abstract
Background
Due to early synanthropization and ecological and behavioral features, the White Stork Ciconia ciconia became the most cherished of European birds. Rooted in human culture, the species has been well studied; nevertheless, knowledge of people’s attitudes and stork-related folk beliefs remain descriptive. Here, we attempt to quantify these issues in the world's largest stronghold of the species, Poland, in the 1950s.
Methods
The study is based on recently discovered, original nationwide survey data from the 1958 International White Stork Census. These materials were gathered to assess the population size, but they also included issues belonging to the humanities. We have worked them up in a quantitative manner, which has resulted in an original approach rarely found in ethnological studies. We aim to propose an original typology of stork-related beliefs, their spread and regional diversity in Poland and the relationship with stork abundance.
Results
A sample of 2343 questionnaires revealed that affection towards storks was widespread (91.4% positive responses), more so in eastern Poland. The most frequent beliefs relate to respect for the stork (65%) and prophesies (24%), thereafter parental beliefs (7%) and stork biology (3%). Positive attitudes and the dissemination of beliefs increased with stork densities but were unrelated to the respondents’ sex. Utilitarian beliefs outweighed those prioritized in ethnographic studies (e.g. the stork’s human origins) or popular today (baby-bringing), and expressed the real concerns of country folk.
Conclusions
The discovery of long-lost data bordering on ethnology and nature conservation and their novel work-up highlights a realistic dimension of the human-nature relationship and provides a benchmark for further interdisciplinary research.