bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of nitrobenzaldehydes and nitrophenyl ketones by electrophilic amination of nitrobenzyl aryl sulfones
Authors: Wulf Jens‐Peter , Sienkiewicz Krzysztof , Mąkosza Mieczyslaw , Schmitz Ernst 
Published: July 2007

AbstractNitrobenzyl Aryl Sulfones 1a–g react with 3,3‐pentamethylene‐oxaziridine (2) with incorporation of an NH group into the benzylic position, followed by cleavage to nitrobenzaldehydes 4a–d and nitrophenyl ketones 4e–g, respectively.
Chiral anchor groups for oxoanions: Asymmetric synthesis of tetrasubstituted bicyclic guanidines
Authors: Schmidtchen Franz P. , Oswald Heike , Schummer Anita 
Published: July 2007

AbstractThe asymmetric synthesis of a tetrasubstituted bicyclic guanidine 1 is described. This salt may serve as an oxoanionbinding modul in open‐chain artificial receptors. The synthetic key step involves asymmetric alkylation of a Schöllkopf bislactim ether 8a/b to produce after protection/deprotection steps a chiral open‐chain triamine 13 which can be cyclized by thiophosgene as a C1‐building block to yield the target structure 1. The diastereoselectivity (%de) and enantioselectivity (%ee) of the synthetic pathway exceed 94%.
En Route to Thromboxane Compounds from Carbohydrates, II. Halolactonization of 4‐c‐Branched Alkyl Hex‐2‐enopyranosides
Authors: Pelyvás István F. , Lindhorst Thisbe K. , Batta Gyula , Thiem Joachim 
Published: July 2007

AbstractBromolactonization of alkyl 4‐C‐(aminocarbonylmethyl)hex‐2‐enopyranosides 1a and 4a in nonaqueous medium results in an unexpected α‐bromination in the C‐4 side chain.
Zur stereoselektiven Synthese von 2‐O‐Benzyl‐1‐O‐hexadecyl‐sn‐glycerol
Authors: Bauer Friederike , Rueß Klaus‐Peter , Liefländer Manfred 
Published: July 2007

Stereoselective Synthesis of 2‐O‐Benzyl‐1‐O‐hexadecyl‐sn‐glycerolDue to the versatility of 2‐O‐benzyl‐1‐O‐hexadecyl‐sn‐glycerol (7) as building block for various alkyl ether lipids and alkyl ether lyso‐lipids, 7 was prepared from D‐mannit following two different strategies. The final product 7 was obtained either via the intermediate 1,2‐O‐isopropylidene‐sn‐glycerol (1) or via 3,4‐O‐isopropylidene‐D‐mannit (8) in an overall yield of 6% or 11%, respectively.
5‐Alkyliden‐4,5‐dihydro‐1H‐tetrazole mit Vinyl‐ oder Phenyl‐Substituenten
Authors: Quast Helmut , Hergenröther Thomas 
Published: July 2007

5‐Alkylidene‐4,5‐dihydro‐1H‐tetrazoles Substituted by Vinyl or Phenyl Groups.The nitriles 7e–k and 10 are methylated by methyl triflate to afford the N‐methylnitrilium triflates 8e–k and 11 which are allowed to react with methyl azide to produce the tetrazolium triflates 9 · F3CSO3 and 12 · F3CSO3. The crystalline hexafluorophosphates 9 · PF6 and 12 · PF6 are obtained after anion exchange with ammonium hexafluorophosphate. Deprotonation of the tetrazolium cations 9c–g,j,k and 16 furnishes the corresponding alkylidenedihydrotetrazoles 3 and 17 as yellow, distillable oils or sublimable, low melting solids which are extremely sensitive towards moisture and oxygen. The parent compound 3c isomerizes readily to the amino‐1,2,3‐triazol 15. The rearrangement is initiated by traces of moisture inducing formation of methyl azide which acts as a catalyst. Similarily, 17 is cleaved into the amide 19 and phenyl azide which adds to unchanged 17 in a 1,3‐dipolar cycloaddition reaction yielding 18. Nuclear Overhauser experiments demonstrate that, of the two splittings 5J of 3d, the larger one stems from the long‐range coupling between the protons at the same side of the double bond, suggesting a contribution from a through‐space interaction to that coupling. The α‐carbon atoms of 3 and 17 resonate at higher field than those of 2‐alkylidenetetrahydroimidazoles 20 having the same substitution pattern, and even benzylpotassium (21). Furthermore, the down‐field shifts, caused by α‐deprotonation of the cations are smallest in the tetrazole series and hence indicative of extraordinary high electron densities at the α‐carbon atoms of 3 and 17 which may be interpreted in terms of contributions by dipolar resonance structures.
Reaktionen der Trialkylsilyl‐trifluormethansulfonate, XII. Aldol‐Additionsreaktionen mit 2,6‐Bis(trimethylsiloxy)thiophen‐Synthese bicyclischer γ‐Lactone
Authors: Rzehak Werner , Simchen Gerhard 
Published: July 2007

Reactions of Trialkylsilyl Trifluoromethanesulfonates, XII. — Aldol‐Type Reactions with 2,6‐Bis(trimethylsiloxy)thiophene Synthesis of Bicyclic γ‐LactonesIn the presence of trimethylsilyl triflate (2) aromatic aldehydes 4 react with 2,6‐bis(trimethylsiloxy)thiophene (3) to yield the 3,4‐disubstituted thiosuccinic anhydrides 5. By hydrolysis of the products 5 in the presence of lead acetate the diaryl‐substituted cis‐bislactones 8 are obtained. Dialkyl‐substituted cis‐bislactones 10 are formed in a aldol addition of aliphatic aldehydes 9 to 3 catalysed by zinc chloride and subsequent hydrolysis of the intermediates. The synthesis of 3,4‐bis(dialkoxyalkyl)thiosuccinic anhydrides 7 is achieved by the reaction of 3 with carboxylic acid orthoesters 6 catalysed by 2.
Inhibitors of Phenylalanine Ammonia‐Lyase: 2‐Aminoindan‐2‐phosphonic Acid and Related Compounds
Authors: Zoń Jerzy , Amrhein Nikolaus 
Published: July 2007

Abstract2‐Aminoindan‐2‐phosphonic acid (3) was synthesized for the first time both directly from 2‐indanone (7) as well as by alkylation of ethyl diethoxyphosphorylacetate with 1,2‐bis(bromomethyl)benzene (9) via 10–12, respectively. 2‐Hydroxyindan‐2‐phosphonic acid (5) was obtained also from 7 via its diisopropyl ester 8. Compound 3 was found to be a potent inhibitor of the plant enzyme phenylalanine ammonia‐lyase (EC 4.3.1.5) both in vitro and in vivo. Of the related 2‐aminoindan‐2‐carboxylic acid (4), compound 5, and 1‐aminocyclopentylphosphonic acid (6), only 4 inhibited the enzyme but was far less inhibitory than 3.
Enaminbildung aus 2‐Phenyl‐1,3‐indandionen und 1‐Phenylethylamin
Authors: Braun Manfred , Hanuschik Andreas , Steigel Alois , Nagy Edgar 
Published: July 2007

Enamine Formation from 2‐Phenyl‐1,3‐indandiones and 1‐PhenylethylamineThe acid‐catalyzed condensation of 4‐methoxy‐2‐phenyl‐1,3‐indandione (3b) and (R)‐1‐phenylethylamine yields the regioisomeric enamines 4b and 5 in a ratio of 75:25. The structure 4b is assigned to the major isomer by 1H‐NMR spectroscopy and X‐ray structure analysis.
Imidazo[1,2‐a]pyrimidine 2′‐Deoxyribo‐ and 2′,3′‐Dideoxyribonucleosides: Glycosylation of the Nucleobase Anion
Authors: Seela Frank , Gumbiowski Rainer 
Published: July 2007

AbstractThe synthesis of the imidazo[1,2‐a]pyrimidine 2′‐deoxyribonucleosides 2a and 3a related to 2′‐deoxyguanosine or 2′‐deoxyinosine is described. Glycosylation of the nucleobase anion of 5 with 2′‐deoxy‐3,5‐bis‐O‐(4‐methylbenzoyl)‐α‐D‐erythro‐pentofuranosyl chloride (6) yielded stereoselectively the N‐1 β‐D‐deoxyribofuranoside 7. Under the same conditions the 2′,3′‐dideoxyrihalogenoses 11 and 14 were employed to afford anomeric mixtures of glycosylation products (12, 13 and 15, 16). The glycosylation products obtained from the 2′‐deoxyribo‐ and 2′,3′‐dideoxyribo halides were then converted into the final nucleosides (2a, b and 3a, b). The inhibitory activity of the imidazo[1,2‐a]pyrimidine 2′,3′‐dideoxynucleoside 5′‐triphosphates 28a and 28b against HIV reverse transcriptase was tested.
Synthesis of 4‐Epoxy‐4‐c‐methyleneglycosylceramides, Potential Glycosyltransferase Inhibitors
Authors: Plewe Michael , Sandhoff Konrad , Schmidt Richard R. 
Published: July 2007

AbstractD‐Glucose was transformed into the 4‐deoxy‐4‐C‐methylene derivative 1. Dihydroxylation of 1 and then selective O‐tosylation afforded 4‐C‐(tosyloxymethyl)glucoside 3. Subsequent hydrogenolytic O‐debenzylation, selective O‐acetylation, treatment with a base, selective removal of the anomeric O‐acetyl group, and then treatment with trichloroacetonitrile in the presence of a base furnished 4‐epoxy‐4‐C‐methyleneglucosyl donor 7 (α,β mixture). Reaction of 7 with 3‐O‐acyl‐protected azidosphingosines 8a–c in the presence of Et2O.BF3 gave β‐glycosides 9a–c. Compounds 9a–c were transformed into the corresponding glucosylceramide derivatives 10a–c by treatment with triphenylphosphane/water and acyl anhydrides. Satisfactory removal of the O‐benzoyl protective group was difficult; however, O‐acetyl and O‐isobutyryl protective groups could be removed by methanolysis, thus affording from 10b, c the target molecules 11 and 12 with varying alkyl‐chain length. The epoxide 16 with galacto configuration, readily obtained from 1, on treatment with p‐toluenesulfonic acid furnished 4‐C‐(tosyloxymethyl)galactoside 18; this was transformed, as outlined for 3, into the target molecules 25b, c having galacto configuration in the sugar moiety.
6‐Siloxy‐Substituted 5,6‐Dihydro‐4H‐1,2‐oxazines as Key Building Blocks for Natural Products
Authors: Zimmer Reinhold , Collas Markus , Roth Michael , Reißig Hans‐Ulrich 
Published: July 2007

AbstractMethyl (E)‐5‐bromo‐4‐oxo‐2‐pentenoate (6) and the corresponding oxime 5 were prepared in high yields by starting from methyl levulinate (3). The novel nitrosoalkene 8, generated in situ from oxime 5, smoothly added to silyl enol ether 7 to give 1,2‐oxazine 9 and nitrone 10 as byproduct. Methods are described transforming intermediate 9 into unsaturated diketo ester 11, or oximes 13, 15, and 18, which may serve as precursors of pyrenophorin. Reductive ring cleavage of 1,2‐oxazine 9 with Raney nickel efficiently afforded the saturated diketo ester 19. Its intramolecular aldol reaction gave cyclopentenone derivative 20, which is a known precursor of (Z)‐jasmone. Cycloaddition of methyl α‐nitrosoacrylate to silyl enol ether 22 provided 1,2‐oxazine 23. This compound was directly converted into the ant‐trail pheromone 24 by hexacarbonylmolybdenum‐promoted ring contraction.
Photochemische Studien, 62. Untersuchungen zur Photostabilität von Halometason und Prednicarbat in kristallinem Zustand sowie Kristallstruktur von Halometason
Authors: Reisch Johannes , Henkel Gerald , Ekiz‐Gücer Nurten , Nolte Gerald 
Published: July 2007

Photochemical Studies, 62. — Investigation on the Photostability of Halometasone and Prednicarbate in the Crystal State and Crystal Structure of HalometasoneUV irradiation of halometasone (1) in the crystal state yields three photoproducts: 2‐chloro‐6α,‐9‐difluoro‐11β, 17α‐dihydroxy‐16α‐methyl‐3‐oxoandrosta‐1,4‐diene‐17β‐carbaldehyde (3), 2‐chloro‐6α,9‐difluoro‐11β‐hydroxy‐16α‐methylandrosta‐1,4‐diene‐3,17‐dione (4 and the dimerization product 2ξ‐chloro‐2ξ‐(2‐chloro‐6α,9‐difluoro‐11β,2→‐trihydroxy‐16α‐methyl‐3,20‐dioxopregna‐1,4‐dien‐21‐yl)‐6α,9‐difluoro‐11β,17, 21‐trihydroxy‐16α‐methylpregna‐4‐ene‐3,20‐dione (5). The structure of 5 is determined by the molecular packing of 1 in the crystal, as shown by an X‐ray analysis of 1. Two photo‐products are formed after irradiation of prednicarbate (2): 11β, 17‐dihydroxy‐21‐propionyloxypregna‐1,4‐diene‐3,20‐dione (6) and 17‐(ethoxycarbonyloxy)‐11β,21‐dihydroxypregna‐1,4‐diene‐3,20‐dione (7).
Synthesis of Furocoumarin‐Type Potential Intercalative Alkylating and Oxidizing Agents of DNA Through Dimethyldioxirane Epoxidation of Imperatorin and Its Derivatives
Authors: Abou‐Elzahab Mohamed M. , Adam Waldemar , Saha‐Möller Chantu R. 
Published: July 2007

AbstractEpoxidation of imperatorin (1a) by dimethyldioxirane (DMD) affords the natural product prangenin (2a) in excellent yield. Similarly, alloimperatorin (1b) and its methyl and acetate derivatives 1b–d are epoxidized with DMD to give the corresponding epoxides 2b–d in quantitative yields. Furthermore, the reaction of the imperatorin allylic hydroperoxide 1e with DMD, and for comparison with m‐chloroperbenzoic acid (CPBA), yields the diastereomeric epoxy hydroperoxides (R*,S*)‐ and (R*,R*)‐2e in low but of opposite diastereoselectivity. Thus, for DMD the (R*,S*)/(R*,R*‐2e ratio is 56:44 and for CPBA 40:60.
Bausteine von Oligosacchariden, CII. Synthese von modifizierten Derivaten der 2‐Acetamido‐2‐desoxy‐D‐galactose zur Untersuchung der Substratspezifität der Core‐1‐β3‐Gal‐Transferase und der Core‐3‐β3‐GlcNAc‐Transferase der Biosynthese von O‐Glycoproteinen
Authors: Paulsen Hans , Rutz Volker , Brockhausen Inka 
Published: July 2007

Building Units of Oligosaccharides, CII. – Synthesis of Modified Derivatives of 2‐Acetamido‐2‐deoxy‐D‐galactose for the Examination of Substrate Specificities of Core 1‐β3‐Gal‐Transferase and Core 3‐β3‐GlcNAc‐Transferase Involved in the Biosynthesis of O‐GlycoproteinsThe 2‐, 3‐, 4‐, and 6‐deoxy derivatives of benzyl 2‐acetamido‐2‐deoxy‐α‐D‐galactopyranoside (7) have been synthesized to test substrate specificities of glycosyltransferases involved in the biosynthesis of O‐glycoproteins. The core 1‐β3‐Gal‐transferase dose not require the 6‐hydroxyl group for activity in contrast to the glycosylation reaction of the core 3‐β3‐GlcNAc‐transferase which requires the 6‐hydroxyl group. Compounds with reactive groups substituting the 6‐hydroxyl group such as the diazirine 45 could be suitable for photolabeling of the former enzyme. A column for affinity chromatography with the 6‐deoxy derivative as the ligand could be useful to separate the two enzymes during purification.
Neuartige Tricyclen aus Bis(arylthio)bicyclo[3.3.0]octadienen und Trimethylsilylcyanid in Gegenwart von Titan(IV)‐chlorid und Methanol
Authors: Quast Helmut , Carlsen Jürgen , Klaubert Christian Alexander , Peters Eva‐Maria , Peters Karl , von Schnering Hans Georg 
Published: July 2007

Novel Tricyclic Products from Bis(arylthio)bicyclo[3.3.0]octadienes and Trimethylsilyl Cyanide in the Presence of Titanium Tetrachloride and Methanol.A four‐step sequence converting ketones into α,β‐unsaturated nitriles is put to test with the ketones 7 and 13. The tetramethylcyclohexanone 7 reacts with thiophenol or 4‐chlorothiophenol in the presence of titanium tetrachloride and triethylamine to afford the phenyl vinyl sulphides 8. Treatment of 8 with a reagent, obtained from titanium tetrachloride and methanol, subsequent with trimethylsilyl cyanide produces the α‐phenylthionitriles 9 in moderate yields. Oxidation of 9a with 3‐chloroperbenzoic acid yields the α‐phenylsulphinylnitrile 12 which decomposes at temperatures as low as 100°C to furnish a quantitative yield of the unsaturated nitrile 11. — When the mixture of bifunctional vinyl sulphides C2‐, CS‐14a is allowed to react at −30°C with titanium tetrachloride/methanol and, subsequently, with trimethylsilyl cyanide, a mixture of the bicyclic α‐(phenylthio)nitriles exo‐15 and 16 and of the tricyclic products 17 and 18 is obtained. This mixture is separated by chromatography. At 20−25°C, the otherwise identical procedure furnishes an isomer of 17, viz. the tricyclic piperidine 21a which is derived from a novel heterocyclic system. The gross structures are based on spectroscopic evidence. The configurations of 16, 17, and 21b, and the structure of 18 as well, are established by X‐ray diffraction analyses. The mechanisms of the unexpected cyclization reactions leading to the tricyclic products 17, 18, and 21 are discussed.
Novel Concepts in Directed Biaryl Synthesis, XVI. Synthesis and Structure of Benzonaphthopyrans; Helically Distorted, Bridged Biaryls with Different Steric Hindrance at the Axis
Authors: Bringmann Gerhard , Hartung Thomas , Göbel Lothar , Schupp Olaf , Peters Karl , von Schnering Hans Georg 
Published: July 2007

AbstractA simple two‐step synthesis of a series of ether‐type bridged biaryls 3, as favorable models for studies of helimerization processes, is described. Starting from the known corresponding lactones 1, a variety of differently substituted representatives 3 is prepared, greatly varying by the degree of steric hindrance and thus molecular distortion. NMR spectroscopy and especially X‐ray diffraction reveal the ethers 3 to be helically distorted, depending on the size of the ortho substituents R.
Wirkstoffe aus Pilzen, I. Isolierung, Synthese und biologische Wirkung von Coniothyriomycin sowie Synthese und Biotestung analoger offenkettiger Imide
Authors: Krohn Karsten , Franke Claudia , Jones Peter G. , Aust Hans‐Jürgen , Draeger Sigfried , Schulz Barbara 
Published: July 2007

Biologically Active Metabolites of Fungi, I. — Isolation, Synthesis, and Biological Activity of Coniothyriomycin as well as Bioassay of Analoguos Open‐Chain ImidesThe mixed open‐chain imide N‐(3‐chloro‐4‐hydroxyphenyl‐acetyl)fumarate (1), named coniothyriomycin, was isolated as metabolite of the fungus Coniothyrium. The natural product 1 and the analoguos imides 13–15 and 22–24 have been synthesized by base‐catalyzed condensation of the imidates 12a–f with acid chlorides 6a–c or the mixed anhydride 21. The compounds 1 and 13–15 were shown to posess remarkable fungicidal and herbicidal activities in short‐termed tests.
Enzymes in Organic Synthesis, 11. Enantioselective Lactonization of Methyl 3,5‐Dihydroxyalkanoates. — An Access to (3R,5S,6E)‐3‐Hydroxy‐7‐phenyl‐6‐hepten‐5‐olide by Enzyme‐Catalyzed Kinetic Resolution in Organic Solvents
Authors: Henkel Birgitta , Kunath Annamarie , Schick Hans 
Published: July 2007

AbstractBy enzyme‐catalyzed intramolecular transesterification methyl (±)‐(3R*,5S*,6E)‐3,5‐dihydroxy‐7‐phenyl‐6‐heptenoate (rac‐4) can be enantioselectively converted into the δ‐lactone 5. An enantiomeric excess of 80% was obtained by Pancreatin in diethyl ether at ambient temperature. Repetition of the enzyme‐catalyzed lactonization with enantiomerically enriched 3,5‐dihydroxy ester 4/ent‐4 enhanced the e.e. to >99%. Lipases of Pseudomonas and Candida sp. 382 tested in eight organic solvents were less efficient. The absolute configuration of 5, obtained as the major enantiomer in all experiments, has been determined by its conversion into the known (—)‐goniothalamin (6).
Glycosyl Imidates, 55. Synthesis of the Pentasaccharide Moiety of an Asterosaponin
Authors: Bing Han Xiao , Schmidt Richard R. 
Published: July 2007

AbstractReaction of 2‐O‐acetyl‐protected O‐galactosyl trichloroacetimidate 3 as glycosyl donor and 2,4‐di‐O‐unprotected xylopyranoside 2 as glycosyl acceptor furnished in the presence of Et2O · BF3 as catalyst regioselectively β‐(1→4)‐connected disaccharide 4 which gave upon subsequent reaction with O‐quinovosyl trichloroacetimidate 5 as donor β‐(1→2)‐connection, thus affording trisaccharide 6. Removal of the 2‐O‐acetyl group from the galactosyl moiety yielded acceptor 7; its glycosylation with donor 5 furnished β‐connected tetrasaccharide 8. This compound was transformed via 1‐O‐desilylation and then treatment with trichloroacetonitrile in the presence of a base into O‐tetraosyl trichloroacetimidate 10 as glycosyl donor. Reaction of 10 with 3‐O‐unprotected 2,4‐di‐O‐acetyl‐ and 2,4‐di‐O‐benzyl‐protected quinovosides 13 and 16 furnished the desired fully O‐protected pentasaccharides 17 and 18, respectively. Hydrogenolytic O‐debenzylation of 18 furnished the O‐unprotected target molecule 19 which was characterized as its O‐acetyl product 20.
Cycloaddition eines sehr reaktiven Cyanovinylcarbens mit Benzol und 3,4‐Dichlorcyclobuten Molekular‐ und Kristallstruktur von 2,3‐Dichlor‐5‐(1‐cyano‐2‐methyl‐1‐propenyl)‐5‐hausancarbonitril und 7‐(1‐Cyano‐2‐methyl‐1‐propenyl)‐7‐norcaradiencarbonitril
Authors: Franck‐Neumann Michel , Miesch Michel , Gries Stefan , Irngartinger Hermann 
Published: July 2007

Cycloaddition of a Very Reactive Cyanovinylcarbene with Benzene and 3,4‐Dichlorocyclobutene. Molecular and Crystal Structure of 2,3‐Dichloro‐5‐(1‐cyano‐2‐methyl‐1‐propenyl)‐5‐housanecarbonitrile and 7‐(1‐Cyano‐2‐methyl‐1‐propenyl)‐7‐norcaradienecarbonitrileThe cyanovinylcarbene 2 has been generated by photolysis of 3,3‐dimethyl‐3H‐pyrazole‐4,5‐dicarbonitril (1) and the cycloaddition products with benzene and with 3,4‐dichlorocyclobutene have been isolated. The molecular structures of the cycloaddition products 7‐(1‐cyano‐2‐methyl‐1‐propenyl)‐7‐norcaradienecarbonitrile (3) and 2,3‐dichloro‐5‐(1‐cyano‐2‐methyl‐1‐propenyl)‐5‐housanecarbonitrile (4) were determined by X‐ray analyses. The bridging bond of the bicyclo[2.1.0]pentane group in 4 is shortened to 1.515 Å by the electronic interaction of this group with the cyano substituent. The vinyl substituent has no influence because of perpendicular orientation.
Absolute Configuration and Synthesis of 2‐Hydroxy‐2‐(1‐hydroxyethyl)‐3‐methyl‐γ‐butyrolactone, a Presumed Pheromone of Ithomiine Butterflies
Authors: Schulz Stefan 
Published: July 2007

Abstract2‐Hydroxy‐2‐(1‐hydroxyethyl)‐3‐methyl‐γ‐butyrolactone (1) is a constituent of scent glands of male ithomiine butterflies. All diastereomers and the respective (3R)‐enantiomers were synthesized by starting from rac‐ or (3S)‐3‐methyl‐γ‐butyrolactone 3. Their relative configurations were determined by difference NOE‐NMR spectroscopy or by X‐ray diffraction analysis. The absolute configuration of the natural product was determined by gas chromatography on a chiral stationary phase of the respective dioxolane derivatives. The natural lactone could be shown to be the (1′S,2S,3R)‐enantiomer [(1′S,2S,3R)‐1a, ithomiolide A]. In addition, the corresponding ketone, (2S,3R)‐2‐acetyl‐2‐hydroxy‐3‐methyl‐γ‐butyrolactone [(2S,3R)‐5a, ithomiolide B], could be identified as a new natural product from Prittwitzia hymaenea.
Photochemical Reactions of 1‐Aryl‐2(1H)‐pyrimidinones in Alcohol
Authors: Nishio Takehiko 
Published: July 2007

AbstractIrradiation of the 2(1H)‐pyrimidinones 1 in alcohols such as 2‐propanol and ethanol afforded the 1‐(alkoxycarbonylamino)‐3‐(arylimino)‐1‐propenes 4a–c, h and 2‐(alkoxycarbonylamino)‐4‐(arylimino)‐2‐pentenes 4d–g. These photoproducts are formed by trapping the isocyanate intermediates 2, generated initially by the Norrish‐type I cleavage of the ArN—CO bond of the 2(1H)‐pyrimidinones, with the alcohol.
α‐Amidoalkylation of Ambident Nucleophiles by Means of N‐Benzoylbenzaldimine
Authors: Dobrev Alexander , Benin Vladimir , Nechev Lubomir 
Published: July 2007

Abstracttert‐Butyl esters 1a–c and N,N‐disubstituted amides 1d–h of carboxylic acids as well as N‐substituted pyrrolidinones 1i, j and 3‐morpholinone 1k are α‐amidoalkylated with N‐benzoylbenzylideneamine (2). The stereochemical course of the reaction is discussed.
A New Dinitroethylating Agent — N,N,N‐Trimethyl‐2,2‐bis‐(aci‐nitro)ethanaminium Hydroxide (Inner Salt)
Authors: Piotrowska Hanna , Wejroch Krystyna 
Published: July 2007

Abstract2,2‐Dinitroethylation of some C‐H acidic compounds with N,N,N‐trimethyl‐2,2‐bis(aci‐nitro)ethanaminium hydroxide (inner salt) (1) is investigated and the products and byproducts are characterized.
Synthesis and Use of α‐Diazo Oxime Ethers in the Synthesis of Ethylene Diketone Bis(O‐methyloxime) Derivatives
Authors: Shatzmiller Shimon , Bercovici Sorin 
Published: July 2007

AbstractReaction of the lithium salts of oxime ethers 4a–c with methanesulfonyl azide gives the α‐diazo oxime ethers 5a–c. These novel compounds are stable up to 90°C, however, they decompose thermally in refluxing CCl4 and with PdCl2 catalysis to yield the ethylene diketone bis(O‐methoxyloxime) derivatives 6a–c in yields of 85–91%. The preparation and characteristic spectral features of 5a–c are described.