bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinically Relevant Germline Variants in Children With Nonmedullary Thyroid Cancer
Authors: van der Tuin Karin , Ruano Dina , Knijnenburg Jeroen , van der Luijt Rob B , Morreau Hans , Links Thera P , Hes Frederik J ,   Dutch Pediatric Thyroid Cancer Consortium, Klein Hesselink Mariëlle S , Nies Marloes , Bocca Gianni , Brouwers Adrienne H , Burgerhof Johannes G M , van Dam Eveline W C M , Havekes Bas , van den Heuvel-Eibrink Marry M , Corssmit Eleonora P M , Kremer Leontien C M , Netea-Maier Romana T , van der Pal Helena J H , Peeters Robin P , Plukker John T M , Ronckers Cécile M , van Santen Hanneke M , Smit Jan W A , Links Thera P , Tissing Wim J E , van der Tuin Karin , Hes Frederik J , van Velsen Evert F , van Leeuwaarde Rachel S 
Published: February 2024

Abstract

Context
The underlying genetic cause of nonmedullary thyroid cancer (NMTC) in children is often unknown, hampering both predictive testing of family members and preventive clinical management.

Objective
Our objectives were to investigated the potential heritability in the largest childhood NMTC cohort that has been genotyped to date.

Methods
Nationwide retrospective cohort study in tertiary referral centers. In total, 97 patients diagnosed with pediatric NMTC between 1970 and 2020 were included in this study. Patients underwent germline whole genome sequencing. The main outcome measures were mutation detection yield in (1) clinically relevant tumor predisposition genes and (2) genes previously associated with NMTC.

Results
In total, 13 of 97 patients (13%) carried a germline (likely) pathogenic variant in a well-known tumor predisposition gene: APC (n = 1), BRCA2 (n = 2), CHEK2 (n = 4), DICER1 (n = 4), HOXB13 (n = 1), and MITF (n = 1). In addition, 1 patient was diagnosed with Pendred syndrome (SLC26A4) and 9 variants of high interest were found in other NMTC candidate susceptibility genes.

Conclusion
The reported prevalence (13%) of germline variants in well-known tumor predisposing genes and the added value of a revised personal/family history and histology led us to recommend genetic counseling for all patients with childhood NMTC. The detected tumor predisposition syndromes are associated with a risk for second cancers which necessitates additional surveillance of the index patients and presymptomatic genetic testing of at risk family members.
Perioperative Plasma in Addition to Red Blood Cell Transfusions Is Associated With Increased Venous Thromboembolism Risk Postoperatively
Authors: Choi Una E. , Nicholson Ryan C. , Frank Steven M. , Cha Stephanie , Aziz Hamza , Lester Laeben C. , Ariyo Promise , Cho Brian C. , Hensley Nadia B. 
Published: February 2024

BACKGROUND:
Perioperative red blood cell (RBC) transfusions increase venous thromboembolic (VTE) events. Although a previous study found that plasma resuscitation after trauma was associated with increased VTE, the risk associated with additional perioperative plasma is unknown.

METHODS:
A US claims and EHR database (TriNetX Diamond Network) was queried. We compared surgical patients who received perioperative plasma and RBC to patients who received perioperative RBC but not plasma. Subanalyses included (1) all surgeries (n = 48,580) and (2) cardiovascular surgeries (n = 38,918). Propensity score matching was performed for age at surgery, ethnicity, race, sex, overweight and obesity, type 2 diabetes, disorders of lipoprotein metabolism, essential hypertension, neoplasms, nicotine dependence, coagulopathies, sepsis, chronic kidney disease, liver disease, nonsteroidal anti-inflammatory analgesics, platelet aggregation inhibitors, anticoagulants, hemoglobin level, outpatient service utilization, and inpatient services; surgery type was included for “all surgeries” analyses. Outcomes included 30-day mortality, postoperative VTE, pulmonary embolism (PE), and disseminated intravascular coagulation (DIC).

RESULTS:
After matching the surgical cohorts, compared to only RBC, plasma + RBC was associated with higher risk of postoperative mortality (4.52% vs 3.32%, risk ratio [RR]: 1.36 [95% confidence interval, 1.24–1.49]), VTE (3.92% vs 2.70%, RR: 1.36 [1.24–1.49]), PE (1.94% vs 1.33%, RR: 1.46 [1.26–1.68]), and DIC (0.96% vs 0.35%, RR: 2.75 [2.15–3.53]). Among perioperative cardiovascular patients, adding plasma to RBC transfusion was associated with similar increased risk.

CONCLUSIONS:
When compared with perioperative RBC transfusion, adding plasma was associated with increased 30-day postoperative mortality, VTE, PE, and DIC risk among surgical and cardiovascular surgical patients. Reducing unnecessary plasma transfusion should be a focus of patient blood management to improve overall value in health care.
Aplastic anaemia associated with bendamustine therapy – a rare side effect
Authors: Khan Salman , Yetiskul Ekrem , Khan Malik Waleed Zeb , Chavez Reyna Gabriel , Matra Amanda , Khattar George , Odaimi Marcel A. 
Published: February 2024

Introduction: During treatment for malignant lymphoma, cytopenia can develop for several reasons. This can range from mild cytopenias leading to infection and bleeding to full-blown drug-induced aplastic anaemia. While aplastic anaemia affects individuals of all genders and ages, here, we describe aplastic anaemia after chemotherapy exposure to bendamustine in a 65-year-old female with non-Hodgkin’s lymphoma. Case description: A 65-year-old woman with recurrent indolent marginal zone lymphoma and post-chemotherapy with bendamustine and rituximab, presented with a neutropenic fever and was admitted with a leading diagnosis of sepsis. In the previous two weeks, the patient required regular transfusions of packed red blood cells and platelets and maintained a daily ZARXIO® regimen. Laboratory results revealed pancytopenia, and broad-spectrum antibiotics (cefepime/vancomycin) were given. The patient was subsequently admitted to the hospital under the care of the haematology/oncology team and was ultimately diagnosed with aplastic anaemia, likely as a consequence of bendamustine chemoimmunotherapy. She elicited a positive response to the triple immunosuppressive therapy (IST) regimen (two immunotherapeutic agents plus one anti-thymocyte globulin (ATG), after which her cell counts returned to normal. Conclusions: This case underscores the importance of recognising haematologic complications linked to bendamustine and advocates for further research to increase the understanding among healthcare professionals of drug-induced aplastic anaemia. Bendamustine can cause severe autoimmune haemolytic anaemia and aplastic anaemia and may require multiple transfusions and a multidrug regimen for treatment. The use of ATG as a therapeutic intervention is appropriate because it has been effective in treating aplastic anaemia.
Die Auswirkung von Managemententscheidungen: Wie Fachbereichs- und IT-Verantwortliche ihre IT-Kosten effektiv steuern können
Authors: Riedinger Constanze , Huber Melanie , Prinz Niculin 
Published: February 2024

Zusammenfassung
IT-Kosten machen heute einen immer größeren Anteil an den Gesamtkosten von Unternehmen aus. Die Verantwortlichen sind aufgefordert die IT-Kosten zu senken oder zumindest ein effizientes Management sicherzustellen. Oftmals fehlt es dafür an Transparenz und Verständnis für diese Ausgaben. Die Analyse der IT-Kostentreiber ermöglicht ein tieferes Verständnis der Ursachen und Auswirkungen strategischer Entscheidungen. Dieser Beitrag zielt darauf ab, die strategischen IT-Kostentreiber bezüglich des Wirkungshorizonts und des Entscheidungsortes zu analysieren. Die durchgeführte Delphi-Studie zeigt, dass Entscheidungen über diese Kostentreiber größtenteils mittel- bis langfristige Auswirkungen haben. Zudem wird deutlich, dass die IT-Abteilung zwar in den Entscheidungsprozess eingebunden ist, während die finalen Entscheidungen häufig stärker im Fachbereich liegen. Zusammenarbeit und effektive Kommunikation sind deshalb entscheidend und die Verantwortung für IT-Kosten sollte von allen EntscheidungsträgerInnen getragen werden. Dieser Beitrag erweitert die Forschung im IT-Kostenmanagement und sensibilisiert PraktikerInnen für Kostenbeeinflussungshebel und die strategische Diskussion über IT-Kosten und das Wertversprechen der IT.
Examining cancer screening disparities by race/ethnicity and insurance groups: A comparison of 2008 and 2018 National Health Interview Survey (NHIS) data in the United States
Authors: Sun Jingjing , Frick Kevin D. , Liang Hailun , Chow Clifton M. , Aronowitz Sofia , Shi Leiyu 
Published: February 2024

Background
Pervasive differences in cancer screening among race/ethnicity and insurance groups presents a challenge to achieving equitable healthcare access and health outcomes. However, the change in the magnitude of cancer screening disparities over time has not been thoroughly examined using recent public health survey data.

Methods
A retrospective cross-sectional analysis of the 2008 and 2018 National Health Interview Survey (NHIS) database focused on breast, cervical, and colorectal cancer screening rates among race/ethnicity and insurance groups. Multivariable logistic regression models were used to assess the relationship between cancer screening rates, race/ethnicity, and insurance coverage, and to quantify the changes in disparities in 2008 and 2018, adjusting for potential confounders.

Results
Colorectal cancer screening rates increased for all groups, but cervical and mammogram rates remained stagnant for specific groups. Non-Hispanic Asians continued to report consistently lower odds of receiving cervical tests (OR: 0.42, 95% CI: 0.32–0.55, p<0.001) and colorectal cancer screening (OR: 0.55, 95% CI: 0.42–0.72, p<0.001) compared to non-Hispanic Whites in 2018, despite significant improvements since 2008. Non-Hispanic Blacks continued to report higher odds of recent cervical cancer screening (OR: 1.98, 95% CI: 1.47–2.68, p<0.001) and mammograms (OR: 1.32, 95% CI: 1.02–1.71, p<0.05) than non-Hispanic Whites in 2018, consistent with higher odds observed in 2008. Hispanic individuals reported improved colorectal cancer screening over time, with no significant difference compared to non-Hispanics Whites in 2018, despite reporting lower odds in 2008. The uninsured status was associated with significantly lower odds of cancer screening than private insurance for all three cancers in 2008 and 2018.

Conclusion
Despite an overall increase in breast and colorectal cancer screening rates between 2008 and 2018, persistent racial/ethnic and insurance disparities exist among race/ethnicity and insurance groups. These findings highlight the importance of addressing underlying factors contributing to disparities among underserved populations and developing corresponding interventions.
Kamalaśīla’s “Middle Way” (madhyamā pratipad) and His Theory of Spiritual Cultivation: A Study with a Special Focus on the Fourteenth Chapter of the Avikalpapraveśadhāraṇīṭīkā
Authors: Chiou Pei-Lin 
Published: February 2024

Abstract
The “middle wayˮ (madhyamā pratipad) is a concept of great significance in Buddhism. For Mahāyāna philosophers, the concept of the middle way free from the two extremes of superimposition (samāropa) and denial (apavāda) has ontological import. In the history of the development of Mahāyāna thought, we also see a tendency to work out a dimension of the middle way related to yogis’ spiritual cultivation and to combine it with the middle way’s ontological aspect. The eighth-century Mādhyamika thinker Kamalaśīla is one whose theory of the middle way has a close connection with his theory of spiritual cultivation. The purpose of this paper is to explore Kamalaśīla’s view on the relationship between (1) the middle way that lies between the two extremes of superimposition and denial, and (2) his theory of spiritual cultivation. I first clarify Kamalaśīla’s definition of the two extremes of superimposition and denial by examining his Madhyamakāloka and Madhyamakālaṃkārapañjikā. Based on the knowledge thus gained, I then delve into the fourteenth chapter of the Avikalpapraveśadhāraṇīṭīkā, a text where Kamalaśīla clearly reveals his take on the relationship between yogi’s meditative examination and the middle way of the two extremes of superimposition and denial. My conclusion is that for Kamalaśīla, meditative examination from the perspective of Madhyamaka ontology is the means to abandon the two extremes of superimposition and denial. Moreover, the middle way itself consists in the attainment of non-conceptual gnosis (nirvikalpajñāna) and the awareness obtained subsequently to that (pṛṣṭhalabdhajñāna), both of which result from such meditative examination.
The value of fibrinogen combined with D-dimer and neonatal weight in predicting postpartum hemorrhage in vaginal delivery
Authors: Zou Yanke , Zeng Shuai , Huang Changxiao , Liu Ling , Li Li 
Published: February 2024

Abstract

Objectives
The purpose of this study was to explore whether fibrinogen (Fib) can be used as a predictor of postpartum hemorrhage (PPH) in parturients with vaginal delivery, and the value of combining Fib with other indexes to predict postpartum hemorrhage in vaginal delivery.

Methods
A total of 207 parturients who delivered via vagina were divided into PPH group (n=102) and non-PPH group (n=105). The PPH group was further divided into mild PPH group and severe PPH group. The differences of Fib, platelet (PLT), mean platelet volume (MPV), platelet distribution width (PDW), D-dimer (D-D), hemoglobin (HGB) and neonatal weight (Nw) between the two groups were compared to explore the significance of these indexes in predicting PPH.

Results
Fib, PLT and PDW in PPH group were significantly lower than those in non-PPH group, while D-D and Nw in PPH group were significantly higher than those in non-PPH group. In the binary logistic regression model, we found that Fib, D-D and Nw were independently related to PPH. The risk of PPH increased by 9.87 times for every 1 g/L decrease in Fib. The cut-off value of Fib is 4.395 (sensitivity 0.705, specificity 0.922). The AUC value of PPH predicted by Fib combined with D-D and Nw was significantly higher than that of PPH predicted by Fib (p<0.05, 95 % CI 0.00313–0.0587).

Conclusions
Fib, D-D and Nw have good predictive value for PPH of vaginal delivery, among which Fib is the best. The combination of three indexes of Fib, D-D and Nw can predict PPH more systematically and comprehensively, and provide a basis for clinical prevention and treatment of PPH.
The crystal structure of N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-3-(2-methylphenyl)-2-sulfanylprop-2-enamide hydrate, C19H17BrN2O2S2
Authors: Ni Lei-Qiang , Guo Xiao-Meng , Wang Ze-Lin , Sun Juan 
Published: February 2024

Abstract
C19H17BrN2O2S2, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 7.8069(5) Å, b = 8.0787(5) Å, c = 15.7738(9) Å, α = 97.540(2)°, β = 90.179(2)°, γ = 104.507(2)°, V = 954.13(10) Å3, Z = 2, R
gt(F) = 0.0423, wR
ref(F
2) = 0.1134, T = 296.15 K.
Bayesian estimation of equipment reliability with normal-type life distribution based on multiple batch tests
Authors: Liu Haobang , Hu Tao , Chen Tong , Li Minggui , Du Kai 
Published: February 2024

Abstract
The test of new equipment is usually carried out in multiple batches according to the task schedule and test results. Constrained by the test environment, cost, and other factors, the amount of reliability test data in each batch is relatively limited, which brings difficulties to the accurate equipment reliability estimation work. For the reliability simulation tests conducted before each batch tests, it is particularly important to make full use of each batch tests information and simulation tests information to estimate the reliability of the equipment for small sample tests. This study takes the common normal-type life distribution equipment as the research object, and selects the normal-inverse gamma distribution as the equipment life parameters prior distribution based on the Bayesian method. Combined with the system contribution, the fusion weights of each batch tests information are determined and all the batch tests information is fused. Finally, the estimation of equipment reliability based on multiple batch tests is completed. The research results show that this method can integrate the information of each batch test and simulation test, overcome the problem of insufficient information of single batch tests, and provide an effective analytical tool for equipment reliability estimation.
Analysis of radiological features in patients with post-stroke depression and cognitive impairment
Authors: Mu Jun , Li Jiayi 
Published: February 2024

Abstract
Post-stroke depression (PSD) and post-stroke cognitive impairment (PSCI) are common complications following a stroke, significantly impacting the quality of life and survival time of survivors. Currently, the comorbidity of PSCI and PSD is receiving increasing attention, as they share some common clinical characteristics, mechanisms, risk factors, radiological features, and treatment strategies. They influence each other, with the clinical prevalence of PSD comorbid with PSCI reaching as high as 26.15 %. The prevention, screening, diagnosis, and treatment of PSD and PSCI require collaboration across clinical, radiological, and neuropsychological evaluations. This paper aims to summarize the common radiological features of both conditions from a radiological perspective, which may aid in identifying early screening and predictive imaging biomarkers.
Synthesis and antitumor activity of model cyclopentene-[g]annelated isoindigos
Authors: El-Abadelah Mustafa M. , Abdullah Ahmad H. , Zahra Jalal A. , Sabri Salim S. , Bardaweel Sanaa K. , Taha Mutasem O. 
Published: February 2024

Abstract
A set of cyclopenten-[g]annelated isoindigos (5a–g) has been prepared and tested for their in vitro antiproliferative activities against MCF-7 and HL60 cells. Among, the N-1-methyl-5′-nitro derivative (5g) displayed the highest activity against HL60 cells (IC50 = 67 nM) and acted as the most potent Flt3 inhibitor. Compounds 5d–g exhibited moderate activity against MCF-7 (IC50 = 50–80 μM).
Development of an Abbreviated Model for Predicting Functional Movement Screen Score Within Tactical Populations
Authors: Thompson Megan B. , Johnson Quincy R. , Lindsay Keston G. , Dawes J. Jay 
Published: February 2024

Abstract
Thompson, MB, Johnson, QR, Lindsay, KG, and Dawes, JJ. Development of an abbreviated model for predicting functional movement screen score within tactical populations. J Strength Cond Res 38(3): 607–611, 2024—The Functional Movement Screen (FMS) is a tool commonly used to identify compensations when performing 7 specific movement patterns. Timely administration of the full FMS is largely dependent on the practitioner's familiarity and experience with the screening battery. When working in populations that are time-poor (i.e., tactical professionals), administration of the full movement pattern battery is not always feasible. The purpose of this study was to determine which, if any, combination of movement patterns that comprise the FMS could be used to predict total score on this screen among first responders. Functional Movement Screen scores for 99 male subjects (mean ± SD; age: 37.55 ± 9.83 years; height: 180.38 ± 6.59 cm; and body mass: 97.87 ± 15.32 kg) and 9 female subjects (age: 33.22 ± 3.99 years; height: 172.11 ± 8.19 cm; and body mass: 83.99 ± 14.09 kg) from a single law enforcement and fire agency were used for this analysis. Subjects performed the full FMS, which consisted of the following movement patterns: deep squat (DS), hurdle step (HS), in-line lunge (ILL), shoulder mobility (SM), active straight leg raise (ASLR), trunk stability push-up (PU), and rotary stability (RS). A stepwise regression was used to determine the best predictors of the FMS 7-pattern model based on the model's R
2. Cronbach's alpha and Guttman's lambda-2 were used to determine the reliability of the proposed models. The regression indicated that a 4-pattern model consisting of DS, ILL, SM, and PU was sufficient to predict approximately 84% of the full model (adjusted R
2 = 0.84, p ≤ 0.001). This 4-pattern model was shown to be reliable with the 7-pattern model (α = 0.93, λ = 0.93). Using this modified version of the FMS may allow practitioners working in tactical populations a time-efficient method of identifying dysfunctional movement and determine whether the full 7-pattern model of the FMS should be considered.
Smoking Susceptibility and Trends Among Nonsmoking Adolescents: An International Study
Authors: Liu Huaqing , Qi Qi , Duan Ying , Cui Yan , Chen Yan , Zhou Chengchao 
Published: February 2024

OBJECTIVES
Smoking susceptibility is defined as a lack of firm decision against smoking, usually starts in the preparation and/or initiation stages of smoking behavior, and is a strong predictor of smoking experimentation during adolescence. However, the recent global prevalence and trends in smoking susceptibility among adolescents are not well documented. This study assessed global smoking susceptibility and secular trends among nonsmoking adolescents.

METHODS
Smoking susceptibility was analyzed using the most recent data from the Global Youth Tobacco Survey from 129 countries, where the data from each country were drawn from at least 1 survey conducted at any time between 1999 and 2020. Moreover, data from 82 countries were used to assess the average annual rate of change (AARC) in smoking susceptibility over time.

RESULTS
Smoking susceptibility among nonsmoking adolescents was 19.6%. A U-shaped relationship was observed between susceptibility and a country’s economic level. Most countries showed no changes in susceptibility over time. Countries with a significant upward trend in susceptibility were primarily high-income and upper middle-income countries in the American region. At the World Health Organization regional level, susceptibility significantly decreased in the European region (AARC: −3.5%; 95% confidence interval, −5.8 to –0.8); however, it significantly increased in the American region (AARC: 2.2%; 95% confidence interval, 1.3–3.1).

CONCLUSIONS
Smoking susceptibility remains a serious public health challenge among adolescents worldwide. More public health policies are needed to reduce susceptibility and to control its upward trend in the American region and high-income countries.