Female patients complaining about hair loss: documentation of defective scalp hair dynamics with contrast‐enhanced phototrichogram
Authors: Van Neste Dominique 
Published: April 2006

Background: The complaint of chronic hair loss frequently affects female subjects and there is little or no objective technology available in the general dermatology or even in the hair clinics to guide the observer in the management of the patient. The purpose of this report is to share the results of refined hair growth measurements that were collected in 92 female subjects complaining about hair loss.Methods: Clinically they were classified as having a patterned hair loss according to Ludwig (L; n=50), diffuse hair loss (D; n=13) or no visible hair loss but complaining of hair shedding (N; n=29). Two scalp sites on the top of the head and one occipital site were investigated after clipping by close‐up photography before and after a hair dye (contrast enhancement, CE). Forty‐eight hours later a new photograph was taken after CE in view of phototrichogram analysis (CE‐PTG). Finally a last hair clip was performed 30 days later and hair thickness and length determined for linear growth measurements (LHGR).Results: Herein we confirm that the top of the head shows usually a higher hair density than occipital sites, a physiological observation that applies both to men and women. From the technological perspective, we also document that CE improves hair detection in all sites. Interestingly, in affected patients (L and D) the relative increase of hair counts after CE was much higher (range +22.4% to +28.3%) compared with apparently unaffected females (N; range +8.2% to +9.7%). This increase in hair counts was only due in part to the presence of less pigmented thinning hair (thickness less than 40 μm). Such thin hairs were found in statistically significantly higher proportions in younger patients with mildly severe (grade I) patterned alopecia (Ludwig: L). In other patients with hair loss and in more severe forms of patterned alopecia – especially in older patients – the thin hair is not detected in abnormal proportions. In all sites slower growth rates and decreased anagen percentages indicate a defective hair replacement programme distinguishing L patterns from diffuse hair loss and from apparently unaffected patients complaining of chronic hair loss. Globally, we also noted that increasing age is associated with significant regression of scalp hair (decreased hair counts, thinner hair and slower LHGR).Conclusion: On the basis of the present data together with female data from the literature and our own studies in male subjects, we suggest a three‐step mechanism leading to hair loss

Shortening of growth phase the hair cycle with maintained thick hair, i.e. more frequent hair cycling that leads to more hair shedding.
Intermittent production of short thin hair, i.e. morphological evidence of miniaturisation.
Very occasional or almost no hair production, i.e. dormant follicles or irreversible follicular atrophy.

Depending on the genetic background, hormonal microenvironment in the scalp and conditioning of individual hair follicle bio‐responses, female and male patterned hair loss may end up into different phenotypes.