bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular endothelial growth factor (VEGF) receptor antibody bevacizumab (avastin) induces regression of renal cell carcinoma in an adolescent resulting in residual tumorectomy
Authors: Joshi Divya‐Devi , Banerjee Tarit 
Published: May 2007

AbstractRenal cell carcinoma is a chemo‐ and radiation‐resistant malignancy that is very rare in childhood. In advanced cases, survival is extremely poor, but cure can be achieved with complete tumorectomy. We report a 14‐year‐old female with left renal cell carcinoma, with regional lymphadenopathy extending up to the diaphragm. Complete tumor resection was impossible. The tumor progressed after 10 months of treatment with high‐dose interleukin‐2. After 7 months of outpatient vascular endothelial growth factor receptor antibody bevacizumab and no significant adverse effects, dramatic tumor shrinkage enabled complete resection. Pediatr Blood Cancer 2008;50:903–904. © 2007 Wiley‐Liss, Inc.
Protein expression profiles of Bos taurus blood and lymphatic vessel endothelial cells
Authors: Bianchi Laura , Lorenzoni Paola , Bini Luca , Weber Elisabetta , Tani Chiara , Rossi Antonella , Agliano Margherita , Pallini Vitaliano , Sacchi Giovanni 
Published: May 2007

AbstractThe endothelium is a metabolically active organ that regulates the interaction between blood or lymph and the vessel or the surrounding tissue. Blood endothelium has been the object of many investigations whereas lymphatic endothelium biology is yet poorly understood. This report deals with a proteomic approach to the characterization and comparative analysis of lymphatic and blood vessel endothelial cells (ECs). By 2‐DE we visualized the protein profiles of EC extracts from the thoracic aorta, inferior vena cava, and thoracic duct of Bos taurus. The three obtained electropherograms were then analyzed by specific software, and 113 quantitative and 25 qualitative differences were detected between the three endothelial gels. The cluster analysis of qualitative and quantitative differences evidenced the protein pattern of lymphatic ECs to be more similar to the venous than to the arterial one. Moreover, venous ECs were interestingly found showing a protein expression profile more similar to the lymphatic ECs than to the arterial ones. We also identified 64 protein spots by MALDI‐TOF MS and ESI‐IT MS/MS and three reference maps of bovine endothelium were obtained. The functional implications of the identified proteins in vascular endothelial biology are discussed.
Reentrant superconductivity in the strong coupling limit
Authors: Gorczyca A. , Mierzejewski M. 
Published: May 2007

AbstractThe usual approaches to the reentrant superconductivity are based on the mean field approximation. Here, we investigate this effect carrying out exact diagonalization of finite systems. We have found a nonmonotonic field dependence of the pair susceptibility both in the weak and strong coupling limit. This result strongly supports the possible onset of the reentrant superconductivity in the presence of strong magnetic field. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
On the way to InGaN quantum dots embedded into monolithic nitride cavities
Authors: Sebald K. , Lohmeyer H. , Gutowski J. , Yamaguchi T. , Kruse C. , Hommel D. , Wiersig J. , Jahnke F. 
Published: May 2007

AbstractWe present photoluminescence measurements on single InGaN quantum dots (QDs) grown by metalorganic vapor phase epitaxy, and on monolithicly grown GaN‐based quantum well airpost pillar microcavities. The observed sharp emission lines of the quantum dots are characterized by excitation density dependent measurements. The photoluminescence of individual quantum dots can easily be detected for temperatures up to 150 K. The micro‐photoluminescence measurements on microcavities reveal three‐dimensional confined optical modes which are not seen in the luminescence of the simply planar cavity. The realization of rather temperature stable QDs as well as of nitride based microcavity samples are promising with respect to the intended implementation of QD layers into microcavities. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Photoluminescence and optical reflectance investigation of semipolar and nonpolar GaN
Authors: Kojima Kazunobu , Ueda Masaya , Funato Mitsuru , Kawakami Yoichi 
Published: May 2007

AbstractOptical properties of semipolar and nonpolar unstrained GaN are studied employing photoluminescence, optical reflectance and the k·p perturbation theory in this article. We find that donor bound and free A excitons show a strong polarization for photoluminescence in {11$ \bar 2 $2} and {10$ \bar 1 $0} GaN, while that of B excitons has only a little dependence on crystal orientations. Optical reflectance measurements are also performed to investigate resonance energies and transition probabilities of free excitons. The oscillator strength of A and C excitons has a strong dependency on the angle between c‐axis and growth direction, while that of B is nearly unchanged in every unstrained GaN plane. The experimental results can be well explained by our k·p calculations. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Magnetotransport in AlGaN/GaN and AlGaN/AlN/GaN heterostructures
Authors: Umana‐Membreno G. A. , Parish G. , Nener B. D. , Buttari D. , Keller S. , Mishra U. K. 
Published: May 2007

AbstractTwo‐dimensional electron gas transport in AlN/GaN and AlGaN/GaN heterostructures has been investigated employing geometrical magnetoresistance measurements and quantitative mobility‐spectrum analysis. The channel magnetoresistance of ungated four‐terminal test structures, with an effective width to length ratio of 10, was measured using pulsed drain‐to‐source voltages equivalent to longitudinal electric fields up to 750 V/cm at magnetic field intensities up to 12 T and sample temperatures from 10 to 300 K. Two distinct electron populations, with significantly different mobilities, are shown to be present in the channel of both AlGaN/AlN/GaN and AlGaN/GaN heterostructures. It is also shown that application of longitudinal electric fields up to 750 V/cm cause a reduction in the mobility of these carrier populations and change the shape of mobility spectrum of the dominant electron population. The origin of these carrier populations is discussed. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Thermal and chemical stabilities of In‐ and N‐polar InN surfaces
Authors: Naoi H. , Muto D. , Hioka T. , Hayakawa Y. , Suzuki A. , Araki T. , Nanishi Y. 
Published: May 2007

AbstractWe have investigated the thermal and the chemical stabilities of In‐ and N‐polar InN surfaces by treating InN films in several environments: annealing in vacuum, etching in KOH solution, and irradiating with atomic hydrogen (H*). For the annealing case, In‐polar films mostly disappeared after 5 min at 550 °C and In‐droplets of various sizes were left on the surface of the samples, whereas N‐polar films showed no noticeable change in thickness and only tiny In‐droplets were formed on the surface. For the KOH case, N‐polar films developed rough surface morphologies by the emergence of hexagonal pyramids, whereas In‐polar films were not etched noticeably. In‐polar films also exhibited a much lower reactivity to H* than that of N‐polar films. As a result, the N‐polar surface was thermally more stable than the In‐polar surface, whereas the In‐polar surface appeared to be chemically more stable than the N‐polar surface. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Application of Chromatography and Chemometrics to Estimate Lipophilicity of Ionic Liquid Cations
Authors: Studzińska Sylwia , Stepnowski Piotr , Buszewski Bogusław 
Published: May 2007

AbstractThe hydrophobicity of ionic liquids, an important physical property, is currently attracting attention of scientists particularly for chemical–biological interactions. In this report, the hydrophobicity of selected ionic liquid (only imidazolium based) cations has been investigated according to some methods: chromatographic analysis, statistical, and chemometric approach. As a consequence, the lipophilicity, which is one of the important factors in biological activity of analyzed compounds, can be established. For that purpose, butyl, octyl, octadecyl, mixed, alkylamide, and cholesterolic packings were chosen and applied to the analysis of eight most commonly used ionic liquid cations. The use of different experimental and theoretical methods allow the estimation of ionic liquids properties. In the present study, chemometric and statistical methods have also been used for the comparison of hydrophobic or hydrophilic character of analyzed compounds and also to estimate their biological activity.
Ab initio investigation of the solvent and electron correlation effects on the geometries and first hyperpolarizabilities of push–pull oligomers
Authors: Perpète Eric A. , Jacquemin Denis 
Published: May 2007

AbstractUsing the HF and MP2 approaches, we have determined the ground‐state geometry and first hyperpolarizability of increasingly long push–pull polyacetylene oligomers. The bulk solvent effects have been assessed at both levels of theory through the Polarizable Continuum Model. For the first hyperpolarizability, the resulting 16 combination of theoretical levels of computation have been compared to evaluate the importance of individual corrections, as well as their additive/ multiplicative character. It turns out that the inclusion of bulk solvent effects is essential for an accurate estimate of the nonlinear optics properties of these push–pull derivatives. © 2007 Wiley Periodicals, Inc. Int J Quantum Chem, 2007
Accuracy of density fitting in calculation of two‐electron repulsion integrals in periodic systems
Authors: Milko Matúš , Noga Jozef , Varga Štefan 
Published: May 2007

AbstractRecently implemented approach to treat the two‐electron (Coulomb) integrals in periodic systems via density fitting has been examined using Hartree‐‐Fock calculations for model systems including trans‐polyacetylene, poly(methineimine), and trans‐polycyanoborane. At the moment, the exchange part of the Fock operator has been taken exact. In addition to total energies, the performance has been assessed for electron densities, main parameters of the band structure as well as for the topology of selected important bands. DZP and 6‐31G** atomic orbital basis sets were combined with different auxiliary sets including standard ones optimized for molecules. For the purpose of systematic comparisons also auxiliary bases based on the correlation consistent cc‐pVXZ and cc‐pCVXZ hierarchies have been examined. Though these hierarchies were not designed for density fitting they perform fairly well, too, exhibiting an exponential convergence behavior with the increasing cardinal number. It is shown that for bands of chemical interest the band structure is well reproduced even with quite small auxiliary sets. © 2007 Wiley Periodicals, Inc. Int J Quantum Chem, 2007
A force field for simulating ethanol adsorption on Au(111) surfaces. A DFT study
Authors: Fartaria Rui P. S. , Freitas Filomena F. M. , Silva Fernandes Fernando M. S. 
Published: May 2007

AbstractThe development of a DFT force field to describe the adsorption of ethanol on Au(111) surfaces is presented. An analytical potential energy function is proposed based on fitting the DFT results by means of genetic algorithms. A preliminary test of the force field by Monte Carlo simulations shows a good consistency between the DFT and simulation results. They are also related to previous theoretical and spectroscopic studies on the adsorption of methanol and ethanol on gold clusters. © 2007 Wiley Periodicals, Inc. Int J Quantum Chem, 2007
Statistical education for medical students—Concepts are what remain when the details are forgotten
Authors: Herman Amir , Notzer Netta , Libman Zipi , Braunstein Rony , Steinberg David M. 
Published: May 2007

AbstractTeaching statistics to medical students is a challenging and often unrewarding task. However, few would argue the need for statistics in the medical school curriculum. In recent years, there has been a growing call for teaching only statistical concepts in medical schools. We strongly oppose this opinion and offer an alternative approach. In this article, we present our experience in teaching statistics to medical students at the Sackler School of Medicine, Tel‐Aviv University, Israel. We then present the results of a recently held survey regarding the long‐term contribution of the statistical curriculum to our
students in different phases of their studies. We conclude by suggesting a new integrative statistical program, which incorporates the study of statistics into the entire medical curriculum. Copyright © 2007 John Wiley & Sons, Ltd.
Harmonizing ISO/IEC 15504 and CMMI
Authors: Rout Terence P. , Tuffley Angela 
Published: May 2007

AbstractThe requirements for conformance of a process model to the international standard for process assessment, ISO/IEC 15504, cover a broad range. The most significant of these is the need to establish a complete and unambiguous mapping between the Process Assessment Model and the relevant Process Reference Model and the Measurement Framework described in the Standard. This is required to support the development of a mechanism for translating the outputs from an assessment using the Process Assessment Model into the standard process profiles defined in ISO/IEC 15504. This article reports the results of an analysis of the relationship between CMMI®, as a ‘candidate conformant Process Assessment Model’, relative to the Measurement Framework defined in ISO/IEC 15504‐2, and the Process Reference Model described in ISO/IEC 12207 Amd 1/2. It is shown that, while in general terms a complete mapping can be established, there are specific areas where coverage is weak. Use of CMMI as a Process Assessment Model in ISO/IEC 15504 Conformant assessments will need to take account of these issues. Copyright © 2007 John Wiley & Sons, Ltd.
Introduction of asymbiotically propagated seedlings of Cephalanthera falcata (Orchidaceae) into natural habitat and investigation of colonized mycorrhizal fungi
Authors: Yamato Masahide , Iwase Koji 
Published: May 2007

AbstractAsymbiotic seedling propagation and introduction of seedlings into a natural habitat were achieved for Cephalanthera falcata. For immature seeds collected 65 days after pollination, high germination rate (av. 50%) was achieved on Hyponex agar medium plates. Root development occurred in about 10% of the protocorms 5 months after seed sowing. Rooted protocorms were transferred to a culture bottle containing 100 ml of the Hyponex agar medium and incubated continually. In about 30% of the transferred individuals, shoot height reached 1.5–2 cm 8 months after the transfer. After acclimatization in wet vermiculite at 4°C for 6 months, 135 individuals were planted in a natural stand of C. falcata in mid February 2001. Shoot appearance rate was 44.4% at the first year and flowering was noted in some plants. At the fifth year, shoots with an average height of 21.6 cm still appeared in four plants, and flowering was noted in three of them. Colonization of mycorrhizal fungi was examined in two of them as well as one wild plant, in which the mycorrhizal fungi were identified to be in Thelephoraceae or Russulaceae. These fungi are known to form ectomycorrhiza with trees, and thus a tripartnership symbiosis consisting of C. falcata, mycorrhizal fungi and trees was suggested. The involvement of ectomycorrhizal fungi might be the reason for the low survival rate in the field experiment, because the distribution of ectomycorrhizal fungi relevant to this orchid is assumed to be uneven. The possibility of introducing artificially propagated orchids into natural habitats was discussed.
Classification of Adipose Tissue Species using Raman Spectroscopy
Authors: Beattie J. Renwick , Bell Steven E. J. , Borggaard Claus , Fearon Anna M. , Moss Bruce W. 
Published: May 2007

AbstractIn this study multivariate analysis of Raman spectra has been used to classify adipose tissue from four different species (chicken, beef, lamb and pork). The adipose samples were dissected from the carcass and their spectra recorded without further preparation. 102 samples were used to create and compare a range of statistical models, which were then tested on 153 independent samples. Of the classical multivariate methods employed, Partial Least Squares Discriminant Analysis (PLSDA) performed best with 99.6% correct classification of species in the test set compared with 96.7% for Principal Component Linear Discrimination Analysis (PCLDA). Kohenen and Feed‐forward artificial neural networks compared well with the PLSDA, giving 98.4 and 99.2% correct classification, respectively.
Over‐expression of heat shock protein 27 attenuates doxorubicin‐induced cardiac dysfunction in mice
Authors: Liu Li , Zhang Xiaojin , Qian Bo , Min Xiaoyan , Gao Xiang , Li Chuanfu , Cheng Yunlin , Huang Jun 
Published: May 2007

AbstractBackgroundOxidative stress and myocyte apoptosis are thought to play an important role in the pathogenesis, progression and prognosis of heart failure (HF). Heat shock protein 27 (Hsp27) has been found to confer resistance to oxidative stress in cultured cells; however, the role of Hsp27 in in‐vivo hearts remains to be determined.AimTo investigate the effects of Hsp27 over‐expression on doxorubicin‐induced HF.Methods and ResultsTransgenic mice (TG) with cardiac specific over‐expression of Hsp27 and their wild type littermates (WT) were challenged with doxorubicin (25 mg/kg, IP) to induce HF. At day 5, TG mice had significantly improved cardiac function and viability and decreased loss of heart weight following doxorubicin exposure compared with WT. In another parallel experiment, doxorubicin‐induced increased levels of reactive oxygen species, protein carbonylation, apoptosis and morphologic changes were detected in the mitochondria in WT hearts, whereas these effects were markedly attenuated in TG hearts. In addition, upregulation of heat shock protein 70 and heme oxygenase‐1 was present in the TG hearts after doxorubicin stimulation in comparison to WT hearts.ConclusionThese findings indicate that Hsp27 may play a key role in resistance to doxorubicin‐induced cardiac dysfunction.
Increased postpartum hemorrhage rates in Australia
Authors: Ford J.B. , Roberts C.L. , Simpson J.M. , Vaughan J. , Cameron C.A. 
Published: May 2007

AbstractObjective: To determine whether changes in risk factors for postpartum hemorrhage (PPH) over time are associated with a rise in postpartum hemorrhage rates. Methods: Population‐based study using linked hospital discharge and birth records from New South Wales, Australia for 752,374 women giving birth, 1994–2002. Analyses include a description of trends and regression analysis of risk factors for postpartum hemorrhage and comparison of predicted and observed rates of postpartum hemorrhage over time. Results: Increasing proportions of women aged 35 years or older, born overseas, nulliparous, having cesarean births, having inductions and/or epidurals, postterm deliveries and large babies were evident. Observed postpartum hemorrhage rates increased from 4.7 to 6.0 per 100 births (P < 0.001) while expected rates, adjusted for covariates, remained steady (P = 0.28). Conclusion: Increases in postpartum hemorrhage are not explained by the changing risk profile of women. It may be that changes in management and/or reporting of postpartum hemorrhage have resulted in higher postpartum hemorrhage rates.
ORIENTAL TYRANNY IN THE EXTREME WEST: REFLECTIONS ON AMITI E ONTARIO AND LE GARE GENEROSE
Authors: POLZONETTI PIERPAOLO 
Published: May 2007

AbstractThis is a study of eighteenth-century operatic representations of slavery in America, focusing primarily on two Italian comic works: Ranieri de’ Calzabigi’s libretto for Amiti e Ontario (1772) and its adaptation, Le gare generose, or ‘The Contests in Generosity’ (1786), set by Giovanni Paisiello. Significant changes between the two are interpreted in relation to these works’ original cultural and political contexts, reconstructed through the examination of contemporary dramatic, journalistic and other non-fictional literature. As an operatic theme, in the late eighteenth century, slavery challenges the long established assumption of the westward migration of progress and civilization.
Efficacy and safety of orbital decompression in treatment of thyroid‐associated ophthalmopathy: long‐term follow‐up of 78 patients
Authors: Jernfors Mia , Välimäki Matti J. , Setälä Kirsi , Malmberg Henrik , Laitinen Kalevi , Pitkäranta Anne 
Published: May 2007

SummaryObjective To study the long‐term results of decompression surgery in patients with thyroid‐associated ophthalmopathy (TAO).Design and methods Retrospective analysis and clinical re‐examination of TAO patients with comparison to healthy controls in Helsinki University Central Hospital.Patients Seventy‐eight patients who had undergone orbital decompression due to TAO by transantral or endonasal technique between the years 1985 and 2000 were invited for re‐examination. For comparison, 79 healthy age‐ and sex‐matched controls underwent a similar examination.Results In comparison to the patients’ preoperative state, proptosis was reduced by 4·7 (2·6) mm (mean (SD)) in the right and 4·4 (2·9) mm in the left globe (P < 0·0001) but did not reach the level of the controls’ globe (P < 0·0001). In the right and left eye of patients, visual acuity improved in 44–55%, remained stable in 27–36% and worsened in 18–20%, but remained significantly worse than in controls (P =0·02–0·001). Prevalence of diplopia was high at the re‐examination (N = 39, 50%), but 54% of those patients considered it less difficult than before the surgery. Among patients and controls, maxillary sinusitis and facial neuralgias were equally common. Sensory disturbances were significantly more frequent in patients (P < 0·0001). In assessment of overall satisfaction with present eye status, the median of the visual analogue scale (VAS) was lower for the patients than the controls (P < 0·0001). The majority of the patients considered the operation very helpful regardless of the technique used.Conclusion For patients with TOA, orbital decompression seems to be an effective and safe treatment.
Assessment of thyroid function and urinary and breast milk iodine concentrations in healthy newborns and their mothers in Tehran
Authors: Ordookhani Arash , Pearce Elizabeth N. , Hedayati Mehdi , Mirmiran Parvin , Salimi Sanam , Azizi Fereidoun , Braverman Lewis E. 
Published: May 2007

SummaryObjective  To measure breast milk iodine (MI) and urinary iodine (UI) concentrations in healthy newborns and their nursing mothers from an iodine‐sufficient region to determine adequacy and to relate these parameters to thyroid function tests in mothers and infants.Design  Cross‐sectional.Patients  Forty‐eight healthy neonates of 37 to 42 weeks’ gestation with normal cord blood TSH values and their mothers were recruited in Tehran, Iran.Measurements  Serum thyroid function tests were performed, and maternal and infant urinary iodine excretion, and maternal MI concentration were measured.Results  Neonatal age was 12·9 ± 3·9 (mean ± SD; range 7–30) days and maternal age was 25·8 ± 5 years. Median (range) UI in neonates was 271 µg/l (57–800) and in mothers was 107 µg/l (20–710). Median (range) MI was 148 µg/l (45–750). Neonatal and maternal UI did not correlate with serum thyroid function tests. UI < 150, 150–230, and > 230 µg/l was found in 20, 12·5, and 67·5% of neonates and 79·1, 14, and 7% of mothers, respectively. MI was < 150, 150–180, and > 180 µg/l in 52·4, 11·9, and 35·7% of mothers, respectively.Conclusions  Among euthyroid neonates, UI was adequate despite low median maternal UI and MI concentrations. There were no significant correlations between UI or MI and thyroid function tests in the mothers and infants.