bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase-Space and Dissipation Studies of the Dancing Wing Nut
Authors: Thompson J. Michael T. 
Published: March 2024

In this paper, we address the nonlinear dynamics of Dzhanibekov’s dancing wing nut and the related intermediate axes theorem governing the motion of a tossed tennis racket. Drawing first on the comprehensive investigations by Murakami, Rios and Impelluso [J. Appl. Mech. 83 (2016), doi:10.1115/1.4034318] we extend the exploration of the wing nut’s spherical phase portrait by incorporating basins of attraction and their heteroclinic connections. We then turn our attention to the significant damping studies of Español, Thachuk and de la Torre [Eur. J. Mech. A Solids 103, 105184 (2024)] who derive from first principles a generalized stochastic version of the Euler equations which can incorporate both oriental realignment (which they call oriental diffusion) and viscoelastic effects. Applied to the wing nut dancing, they showed that the former is the more significant effect and as the authors say “Had Dzhanibekov observed his wing nut for a sufficiently long period, he would have found it spinning around the major axis. In other words, precession relaxation kills the Dzhanibekov effect in the long run.”
Evolocumab Treatment in Pediatric Patients With Homozygous Familial Hypercholesterolemia: Pooled Data From Three Open-Label Studies
Authors: Raal Frederick J. , Hegele Robert A. , Ruzza Andrea , López J. Antonio G. , Bhatia Ajay K. , Wu Johnny , Wang Huei , Gaudet Daniel , Wiegman Albert , Wang Jian , Santos Raul D. 
Published: March 2024

BACKGROUND:
Pediatric patients with homozygous familial hypercholesterolemia (HoFH) have an increased risk of atherosclerotic cardiovascular disease and difficulty meeting low-density lipoprotein cholesterol (LDL-C) goals. In this post hoc analysis, we evaluated pooled safety and efficacy data from 3 studies in pediatric patients with HoFH treated with the PCSK9 (proprotein convertase subtilisin/kexin type 9) monoclonal antibody inhibitor evolocumab.

METHODS:
Patients with HoFH aged 10 to 17 years received treatment with open-label evolocumab 420 mg subcutaneously monthly or biweekly in the TAUSSIG, RAMAN, or HAUSER-OLE clinical studies. All patients received background statins with or without ezetimibe. Study duration ranged from 12 to 260 weeks. The primary end point was treatment-emergent adverse events per 100 patient-years. Efficacy end points were changes from baseline to week 12 in lipids and PCSK9.

RESULTS:

Of the 39 patients in the pooled analysis, 69.2% were males, median age was 13.0 years, and 79.5% (31/39) had genotyped HoFH with
LDLR
pathogenic variants. Overall, median exposure to evolocumab was 18.2 (Q1, Q3: 3.0, 18.5) months. Treatment-emergent adverse events with an exposure-adjusted patient incidence rate of ≥5% were upper respiratory tract infection (6.6%), influenza (5.2%), and acne (5.0%) per 100 patient-years. Exposure-adjusted patient incidence of serious treatment-emergent adverse events was 13.3% per 100 patient-years. Excluding 4 patients receiving lipoprotein apheresis, week 12 median percentage change from baseline in LDL-C was −2.9% (Q1, Q3: −21.7, 1.5); however, 42.9% (15/35) of patients achieved ≥15% reduction in LDL-C from baseline. Residual LDLR (LDL receptor) activity was not associated with a reduction in LDL-C.

CONCLUSIONS:
In this pooled data analysis from 3 studies in pediatric patients with HoFH, evolocumab was well tolerated, with no new safety signals reported. These safety findings are consistent with findings from previous studies of evolocumab. Patients showed marked variability in LDL-C reduction. Results from this pooled analysis support guidelines suggesting a trial of PCSK9 inhibitor therapy regardless of estimated residual LDLR function.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01624142, NCT03403374, and NCT02624869.
The Papacy’s Initial Response to the Ottoman Threat and Its Consequences (1453–1464)
Authors: Alenezi Meshal , Abdelfattah Sanad 
Published: March 2024

Abstract
In 1453, the world witnessed the fall of the medieval Christian Empire’s largest capital, Constantinople, at the hands of the Ottoman Sultan Mehmed II (1444–1446/1451–1481). Some scholars have argued that this event encouraged crusades against the Ottomans throughout Europe. Consequently, this research debates the previous studies by discussing both the primary objectives of the papacy and Christian states after the fall of Constantinople and the presence of Muslims in Western Europe. It also considers the Catholic Church’s actions during its attempts to incite Christian countries to wage war against the Ottoman Empire. Lastly, the study analyses various primary sources, including papal sources, and provides deeper insights into various papal responses to Ottoman threats, comparing them with simultaneous, more enthusiastic support for the Iberian Reconquista.
The Extension of the Liturgical Form for the Celebration of the Lord’s Supper in the Dutch Psalm Book of Dathenus 1568
Authors: Zwemer Sam 
Published: March 2024

Abstract
This article focuses on a specific edition of the Dutch liturgical form for the celebration of the Lord’s Supper. This edition from 1568 contains an extension concerning the words of distribution and the thanksgiving. This modification was done by Dathenus himself. In terms of its origin, this specific edition fits well within the patterns in the genesis of the (Dutch) form for the celebration of the Lord’s Supper itself. The content of the extension includes an invitation, an expansion of the words of distribution, and instruction in the thanksgiving regarding communion with Christ, the eschatological perspective, and living in gratitude. Various motives played a role in this extension, both in terms of the context of its origin and its context of use. This specific text is relevant as it provides more information about the author’s working method, the influence of the London tradition, and a better understanding of later synods and editions of the psalm book.
Motivational Orientation, Boredom and Fun in Physical Education: The Mediation Role of Self-Esteem and Motor Self-Efficacy
Authors: Reigal Rafael E. , Hernández-Martos Jacobo , Monteiro Diogo , Pérez-López Rocío , Hernández-Mendo Antonio , Morales-Sánchez Verónica 
Published: March 2024

Adolescents who enjoy physical education (PE) classes are more likely to be active during out-of-school hours. Similarly, achievement goal theory suggests that task-oriented motivation is associated with higher levels of reported fun during PE classes. In contrast, ego-oriented motivation has been related to boredom in class, but some self-perceptions (e.g., self-esteem or motoric self-efficacy) may modify this relationship and are important for physical activity. Our aim in this paper was to analyze the relationships between motivational orientation and fun and boredom in PE classes by assessing the mediating effects of self-esteem and self-efficacy. We surveyed 478 teenagers between 13 and 18 years of age ( M = 14.57; SD = 1.15) with the Task and Ego Orientation in Sport Questionnaire (TEOSQ), the Rosenberg Self-Esteem Scale (RSE), the Motor Self-Efficacy Scale (MSES), and the Intrinsic Satisfaction in Sport Scale (SSI-EF). We used a structural equation model to evaluate relationships between these variables of interest. We found a positive relationship between ego orientation and boredom and between task orientation and fun; and we found a negative relationship between task orientation and boredom in PE classes. Importantly, we observed indirect effects from self-esteem and motoric self-efficacy in the relationships between motivational orientation and boredom and fun in PE. These results highlight the importance of students’ motivational orientations in PE classes and illustrate that self-perception of self-esteem and motoric self-efficacy can mediate these relationships.
Internationally Educated Nursing Staff Caring for Older Adults: A Scoping Study
Authors: Olanrewaju Sherif A. , Loeb Susan J. 
Published: March 2024

Introduction: Internationally Educated Nursing staff (IENs) are born and obtained their initial educational preparation in their home country before relocating to work in high-income countries (e.g., United States). Older adults are recipients of IENs’ care. The study purpose was to synthesize relevant findings on IENs’ experiences caring for older adults in various settings. Method: Arksey and O’Malley’s framework approach to Scoping studies was employed. The PubMed, CINAHL, PsycINFO, Web of Science, and Google Scholar databases were searched. A labor and employment relations researcher and a health science librarian were consulted. Results: Three main themes (transitional challenges; IENs’ experiences working with older adults; factors affecting IEN service delivery) and seven subthemes emerged. Discussion: Cultural beliefs and communication barriers posed particular challenges to IENs as they worked with Western peers, older adults, and families. Facilitating factors revealed can inform administrative leaders of practice initiatives. Research gaps and limitations identified can guide future study approaches.
Measuring the Level of Fidelity Required for Transfer of Learning in Simulation-Based Learning Exercises for Novice and Experienced Practitioners
Authors: Davies Amanda Jane , Krame Ghaleb 
Published: March 2024

Background An acknowledged conundrum which exists for designers of simulation-based learning exercises centres on how much fidelity is required to aid transfer of learning from the classroom to the field of application and what is the influence of the learner’s practitioner experience. This article presents the findings from a study which explored the way in which fidelity influences the sense of immersion and learning transfer experienced by novice and experienced practitioners in technology-assisted simulation-based learning exercises. Methods Two different technology-assisted simulation-based learning exercises were explored employing participant surveys and interviews. The central aim of the exercises, conducted by an Australian police agency was the development of decision-making skills for high-risk and high-stakes situations. Case one centred on public order management for highly experienced senior police and Case Two was a judgmental use-of-force simulation for novice police recruits with limited or nil operational experience. Results The findings indicate experienced practitioners did not suggest a need to actually see a replicated site of the incident with the human and environmental elements and sounds. They relied on their policing experience to build their own visualization of the situation. It is the combination of this personal visualization with the psychological factors of the simulated incident which created a realistic environment for these experienced practitioners. For the novice practitioners – they relied on the simulation exercise and environmental features to be as realistic and extensive as possible in order to experience immersion and presence. Conclusion This study supports the suggestion that measuring how much fidelity is enough or too much is complex, and a unit of measurement could reasonably be identified as determining the balance of physical and psychological fidelity, informed by the field-based experience of the participants, which will support learning transfer from the classroom (or simulated environment) to the field of operation.
A successful desensitization in an adult patient with ARA-C infusion reaction
Authors: Akgul Balaban Yasemin , Inan Mustafa Ilker , Selcuk Ali , Kartal Ozgur , Zengin Haydar , Bulduk Tuba 
Published: March 2024

Introduction Cytarabine (ARA-C) is an antimetabolite agent used especially in the treatment of hematologic malignancies. Infusion reactions have an important place among the side effects that may occur due to treatment. Clinical findings of infusion reactions resemble allergic reactions. Case Report 47-year-old male patient with a diagnosis of B-cell Acute Lymphoblastic Leukaemia developed infusion reaction during ARA-C treatment. Management & Outcome There was no alternative treatment option for his existing malignant disease, we decided ARA-C desensitization. Discussion We would like to describe a successful desensitization protocol in an adult patient who experienced a reaction during ARA-C infusion.
Therapeutic Effect of Silver Nanoparticles in the Management of Diabetic Ulcers: A Systematic Review and Meta-Analysis on RCTs
Authors: Hosseini Reza Shah , Hasanpour Kiana , Khoshnevis Mehrnoosh , fakhr Masoud Saadat , Derin Esra , Ghaffarian Alireza , Kement Cagdas 
Published: March 2024

Aims The skin, as the body's largest organ, plays vital roles in sensory functions, temperature regulation, and protection against pathogens and injuries. Skin wounds, which disrupt its integrity, can result from various factors, including diseases such as diabetes. Diabetic foot ulcers are a severe complication of diabetes, often leading to amputations. This systematic review explores the therapeutic potential of silver nanoparticles in the management of diabetic ulcers. Methods Seven studies published between 2016 and 2023 were included in this review. Also, 4 studies were included in the meta-analysis. These studies investigated the application of silver nanoparticles, primarily in dressing forms, for diabetic ulcer treatment. A systematic search strategy was employed, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Results The results show that silver nanoparticles do not have a significant difference in improving DFU healing rates. SilvrSTAT Gel, a dressing containing silver nanoparticles, outperformed traditional dressings, leading to a substantial percentage of ulcers healing within weeks. Comparative studies also indicated that silver nanoparticles were at least as effective as alternative treatments, such as nano-chitosan dressings, and showed potential for combination therapy with growth factors. Discussion This review underscores the promise of silver nanoparticles, a nanotechnology-based approach, in accelerating the healing of diabetic ulcers while providing antimicrobial benefits. Despite some limitations, including variations in treatment regimens and a lack of long-term outcome data, these findings show there is no clinical evidence for using Nanosilver for the healing process of DFU. Conclusion Silver nanoparticles currently do not have sufficient clinical evidence for healing the DFU; however, in some studies, they had noticeable effects on the rate of wound healing.
Effects of Blood flow Restriction and Load on Mean Propulsive Velocity and Subjective Perceived Exertion During Squat and Bench Press Exercises
Authors: Serrano-Ramón Josep M. , García-Luna Marco A. , Hernández-Sánchez Sergio , Cortell-Tormo Juan M. , García-Jaén Miguel 
Published: March 2024

Background: The aim of this study was to determine the influence of different percentages of blood flow restriction (BFR) and loads on mean propulsive velocity (MPV) and subjective perceived exertion during squat (SQ) and bench press (BP) exercises. Hypothesis: Higher percentages of BFR will positively affect dependent variables, increasing MPV and reducing perceived exertion. Study Design: Cross-sectional study. Level of Evidence: Level 3. Methods: Eight healthy young male athletes took part. Two sets of 6 repetitions at 70% 1-repetition maximum (1RM), 2 sets of 4 repetitions at 80% 1RM, and 2 sets of 2 repetitions at 90% 1RM were performed randomly; 5-minute recoveries were applied in all sets. The varying arterial occlusion pressure (AOP) applied randomly was 0% (Control [CON]), 80%, and 100%. Results: No statistically significant differences in MPV were found during the BP exercise at any percentage of BFR at any percentage 1RM. During the SQ exercise, MPV results showed statistically significant increases of 5.46% ( P = 0.04; ηp2 = 0.31) between CON and 100% AOP at 90% 1RM. The perceived exertion results for the BP exercise showed statistically significant reductions of -8.66% ( P < 0.01; ηp2 = 0.06) between CON and 100% AOP at 90% 1RM. During the SQ exercise, the perceived exertion results showed significant reductions of -10.04% ( P = 0.04; ηp2 = 0.40) between CON and 100% AOP at 80% 1RM; -5.47% ( P = 0.02; ηp2 = 0.48) between CON and 80% AOP at 90% 1RM; and -11.83% ( P < 0.01; ηp2 = 0.66) between CON and 100% AOP at 90% 1RM. Conclusion: BFR percentages ~100% AOP at 90% 1RM improved acutely MPV (only in SQ exercises) and reduced acutely perceived exertion (in both exercises). These findings are important to consider when prescribing resistance training for healthy male athletes.
Interval Throwing Programs for Baseball Players: Methodological Assessment of the Quality and Construct of Publicly Available Programs
Authors: Boos Alexander M. , Sambare Namit , Smith Matthew V. , Freehill Michael T. , Bowman Eric N. , Erickson Brandon J. , Chalmers Peter N. , Sciascia Aaron , Camp Christopher L. 
Published: March 2024

Context: The quality and interprogram variability of publicly available throwing programs have not been assessed. Objective: To (1) identify publicly available interval throwing programs, (2) describe their components and structure, and (3) evaluate their quality, variability, and completeness. Data Sources: Google, Bing, Yahoo; keyword: “interval throwing program.” Study Selection: Baseball-specific publicly available programs. Study Design: Systematic review. Level of Evidence: Level 4. Data Extraction: Independent evaluation by 2 authors using a novel 21-item Quality Assessment Rubric (QAR). Results: Of the 99 included programs, 54% were designed for return from injury/surgery; 42% explicitly stated no expected timeline for completion, and approximately 40% did not provide criteria to initiate the program. Program construction was highly variable. There were broad-ranging shortest (mean: 40±8 ft, range: 20-45 ft) and longest (mean: 150±33 ft, range: 90-250 ft) long toss distances, and variable maximum numbers of mound pitches thrown before returning to game play (range: 40-120, mean: 85). Only 63% of programs provided guidelines for handling setbacks, and standardized warm-ups, arm care, and concomitant training were absent in 32%, 63%, and 47% of programs, respectively. Mean QAR completion rate and QAR item response rate were low (62 ± 4% [range, 24-91%], 62 ± 24% [range, 7-99%], respectively). Finally, only 20 (20%) programs provided at least 1 peer-reviewed reference, most of which were published >10 years ago. Conclusion: Publicly available interval throwing programs are readily available but demonstrate significant interprogram heterogeneity across multiple areas including target audience, program construction, progression, and execution. The quality and consistency of publicly available interval throwing programs is poor at this time, which may limit their utility and effectiveness for baseball players attempting to return to competition. This work identifies a multitude of deficiencies in currently available throwing programs that should be targets of future improvement efforts.
Objective Evaluation of Pulse Width Using an Array Pulse Diagram
Authors: Bi Zi-Juan , Cui Ji , Yao Xing-Hua , Hu Xiao-Juan , Wang Si-Han , Liang Meng-Chen , Zhou Zhi-Hui , Xu Jia-Tuo 
Published: March 2024

Background Pulse width, which can reflect qi, blood excess, and deficiency, has been used for diagnosing diseases and determining the prognosis in traditional Chinese medicine (TCM). This study aimed to devise an objective method to measure the pulse width based on an array pulse diagram for objective diagnosis. Methods The channel 6, the region wherein the pulse wave signal is the strongest, is located in the middle of the pulse sensor array and at the guan position of cunkou during data collection. Therefore, the main wave (h1) time of the pulse wave was collected from the channel 6 through calculation. The left h1 time was collected from the remaining 11 channels. The amplitudes at these time points were extracted as the h1 amplitudes for each channel. However, the pulse width could not be calculated accurately at 12 points. Consequently, a bioharmonic spline interpolation algorithm was used to interpolate the h1 amplitude data obtained from the horizontal and vertical points, yielding 651 (31 × 21) h1 amplitude data. The 651 data points were converted into a heat map to intuitively calculate the pulse width. The pulse width was calculated by multiplying the number of grids on the vertical axis with the unit length of the grid. The pulse width was determined by TCM doctors to verify the pulse width measurement accuracy. Meanwhile, a color Doppler ultrasound examination of the volunteers’ radial arteries was performed and the intravascular meridian widths of the radial artery compared with the calculated pulse widths to determine the reliability. Results The pulse width determined using the maximal h1 amplitude method was comparable with the radial artery intravascular meridian widths measured using color Doppler ultrasound. The h1 amplitude was higher in the high blood pressure group and the pulse width was greater. Conclusions The pulse width determined using the maximal h1 amplitude was objective and accurate. Comparison between the pulse widths of the normal and high blood pressure groups verified the reliability of the method.
A Systematic Review of Interventions That Address Food Insecurity for Persons With Prediabetes or Diabetes Using the RE-AIM Framework
Authors: Whitehouse Christina R. , Akyirem Samuel , Petoskey Christopher , Huang Shuyuan , Lendvai Dora , Batten Janene , Whittemore Robin 
Published: March 2024

Purpose The purpose of this study is to systematically review interventions that address food insecurity for persons with prediabetes or type 2 diabetes using the RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance) framework. Methods Six databases (OVIDMEDLINE, OVIDEMBASE, OVID APA PsycINFO, Web of Science, Cochrane Central Registry of Controlled Trials, and EBSCO CINAHL Complete) were searched through January 2023. Research team members independently performed screening of abstracts and full texts, data abstraction, and risk assessment. Results In all, 3,139 unique citations were identified, and 20 studies met inclusion criteria. Interventions included medically tailored meals/groceries (n = 10) or produce prescriptions/vouchers (n = 10). Reach and effectiveness were the highest reported RE-AIM elements. Interventions reached a high-risk population via food banks, community-based outreach, and federally qualified health centers. A majority of participants identified as female, Black, or Hispanic/Latinx and were living below the federal poverty level. Most studies reported at least 1 diabetes outcome (ie, A1C, hypoglycemia, diabetes distress, diabetes self-management). Seventeen studies reported impact on A1C, with the majority reporting a decrease in A1C and 53% (9/17) of studies demonstrating a decrease over time. Self-management improved in 50% (3/6) of studies that evaluated this outcome. Self-efficacy improved in 40% (2/5) of studies, and improvements were seen in depressive symptoms/diabetes distress (4/7 studies) and quality of life (5/5 studies). Seven studies reported statistically significant improvements in food insecurity. Conclusion Food insecurity has been associated with higher risks and adverse clinical outcomes in adults with diabetes. Implementing interventions that address food insecurity among adults with or at risk for diabetes can enhance food security and clinically important diabetes-related outcomes. Additional research dedicated to the sustainability of interventions is needed.