bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the Antibody Response to an Immunodominant Epitope of the Envelope Glycoprotein of a Lentivirus and Its Diagnostic Potential
Authors: Mordasini Franca , Vogt Hans-Rudolf , Zahno Marie-Luise , Maeschli Ariane , Nenci Chiara , Zanoni Reto , Peterhans Ernst , Bertoni Giuseppe 
Published: March 2006

ABSTRACT
The envelope glycoprotein of small ruminant lentiviruses (SRLV) is a major target of the humoral immune response and contains several linear B-cell epitopes. We amplified and sequenced the genomic segment encoding the SU5 antigenic site of the envelope glycoprotein of several SRLV field isolates. With synthetic peptides based on the deduced amino acid sequences of SU5 in an enzyme-linked immunosorbent assay (ELISA), we have (i) proved the immunodominance of this region regardless of its high variability, (ii) defined the epitopes encompassed by SU5, (iii) illustrated the rapid and peculiar kinetics of seroconversion to this antigenic site, and (iv) shown the rapid and strong maturation of the avidity of the anti-SU5 antibody. Finally, we demonstrated the modular diagnostic potential of SU5 peptides. Under Swiss field conditions, the SU5 ELISA was shown to detect the majority of infected animals and, when applied in a molecular epidemiological context, to permit rapid phylogenetic classification of the infecting virus.
Shushaku Endo (1923–1996): his tuberculosis and his writings
Authors: Sharma O P 
Published: March 2006

Abstract
Shushaku Endo, one of the finest 20th century Japanese novelists, is not as well known in the West as some of his contemporary Japanese writers including, Yukio Mishima, Yasunari Kawabata, Kobo Abe, and Kenzaburo Oe. Mishima deals with turmoil of adolescence laced with surrealistic historical romance; Abe conjures strange, evocative images in the Kafkaesque tradition; Kawabata writes about loneliness and desolation; and Oe creates imaginary themes of life and myth that entwine and portray human predicaments. Kawabata and Oe both received Nobel Prizes in Literature. Endo's writing is different. He confronts problems pertaining to faith, morality, and individual responsibility. In his early years Endo struggled as a loner, an outsider, and a misfit. This pattern continued to a large extent into his adult life, most of which was consumed with fighting his life threatening tuberculosis. The agonies of his illness intensified his talent for exploring the complexity of human relationships.
Memory clinics
Authors: Jolley D , Benbow S M , Grizzell M 
Published: March 2006

AbstractMemory clinics were first described in the 1980s. They have become accepted worldwide as useful vehicles for improving practice in the identification, investigation, and treatment of memory disorders, including dementia. They are provided in various settings, the setting determining clientele and practice. All aim to facilitate referral from GPs, other specialists, or by self referral, in the early stages of impairment, and to avoid the stigma associated with psychiatric services. They bring together professionals with a range of skills for the benefit of patients, carers, and colleagues, and contribute to health promotion, health education, audit, and research, as well as service to patients.
A NONLINEAR DYNAMICS PERSPECTIVE OF WOLFRAM'S NEW KIND OF SCIENCE PART V: FRACTALS EVERYWHERE
Authors: CHUA LEON O. , SBITNEV VALERY I. , YOON SOOK 
Published: March 2006

This fifth installment is devoted to an in-depth study of CA Characteristic Functions, a unified global representation for all 256 one-dimensional Cellular Automata local rules. Except for eight rather special local rules whose global dynamics are described by an affine (mod 1) function of only one binary cell state variable, all characteristic functions exhibit a fractal geometry where self-similar two-dimensional substructures manifest themselves, ad infinitum, as the number of cells (I + 1) → ∞. In addition to a complete gallery of time-1 characteristic functions for all 256 local rules, an accompanying table of explicit formulas is given for generating these characteristic functions directly from binary bit-strings, as in a digital-to-analog converter. To illustrate the potential applications of these fundamental formulas, we prove rigorously that the "right-copycat" local rule [Formula: see text] is equivalent globally to the classic "left-shift" Bernoulli map. Similarly, we prove the "left-copycat" local rule [Formula: see text] is equivalent globally to the "right-shift" inverse Bernoulli map. Various geometrical and analytical properties have been identified from each characteristic function and explained rigorously. In particular, two-level stratified subpatterns found in most characteristic functions are shown to emerge if, and only if, b1 ≠ 0, where b1 is the "synaptic coefficient" associated with the cell differential equation developed in Part I. Gardens of Eden are derived from the decimal range of the characteristic function of each local rule and tabulated. Each of these binary strings has no predecessors (pre-image) and has therefore no past, but only the present and the future. Even more fascinating, many local rules are endowed with binary configurations which not only have no predecessors, but are also fixed points of the characteristic functions. To dramatize that such points have no past, and no future, they are henceforth christened "Isles of Eden". They too have been identified and tabulated.
Surface Cloud Forcing in the East Pacific Stratus Deck/Cold Tongue/ITCZ Complex*
Authors: Cronin Meghan F. , Bond Nicholas A. , Fairall Christopher W. , Weller Robert A. 
Published: March 2006

Abstract
Data from the Eastern Pacific Investigation of Climate Studies (EPIC) mooring array are used to evaluate the annual cycle of surface cloud forcing in the far eastern Pacific stratus cloud deck/cold tongue/intertropical convergence zone complex. Data include downwelling surface solar and longwave radiation from 10 EPIC-enhanced Tropical Atmosphere Ocean (TAO) moorings from 8°S, 95°W to 12°N, 95°W, and the Woods Hole Improved Meteorology (IMET) mooring in the stratus cloud deck region at 20°S, 85°W. Surface cloud forcing is defined as the observed downwelling radiation at the surface minus the clear-sky value. Solar cloud forcing and longwave cloud forcing are anticorrelated at all latitudes from 12°N to 20°S: clouds tended to reduce the downward solar radiation and to a lesser extent increase the downward longwave radiation at the surface. The relative amount of solar radiation reduction and longwave increase depends upon cloud type and varies with latitude. A statistical relationship between solar and longwave surface cloud forcing is developed for rainy and dry periods and for the full record length in six latitudinal regions: northeast tropical warm pool, ITCZ, frontal zone, cold tongue, southern, and stratus deck regions. The buoy cloud forcing observations and empirical relations are compared with the International Satellite Cloud Climatology Project (ISCCP) radiative flux data (FD) dataset and are used as benchmarks to evaluate surface cloud forcing in the NCEP Reanalysis 2 (NCEP2) and 40-yr ECMWF Re-Analysis (ERA-40). ERA-40 and NCEP2 cloud forcing (both solar and longwave) showed large discrepancies with observations, being too large in the ITCZ and equatorial regions and too weak under the stratus deck at 20°S and north to the equator during the cool season from July to December. In particular the NCEP2 cloud forcing at the equator was nearly identical to the ITCZ region and thus had significantly larger solar cloud forcing and smaller longwave cloud forcing than observed. The net result of the solar and longwave cloud forcing deviations is that there is too little radiative warming in the ITCZ and southward to 8°S during the warm season and too much radiative warming under the stratus deck at 20°S and northward to the equator during the cold season.
Physically Based Global Downscaling: Regional Evaluation
Authors: Ghan Steven J. , Shippert Timothy , Fox Jared 
Published: March 2006

Abstract
The climate simulated by a global atmosphere–land model with a physically based subgrid orography scheme is evaluated in 10 selected regions. Climate variables simulated for each of multiple elevation classes within each grid cell are mapped according to a high-resolution distribution of surface elevation in each region. Comparison of the simulated annual mean climate with gridded observations leads to the following conclusions. At low to moderate elevations the downscaling scheme correctly simulates increasing precipitation, decreasing temperature, and increasing snow with increasing elevation across distances smaller than 100 km. At high elevations the downscaling scheme correctly simulates decreasing precipitation with increasing elevation. The rain shadow of many mountain ranges is poorly resolved, with too little precipitation simulated on the windward side of mountain ranges and too much on the lee side. The simulated sensitivity of surface air temperature to surface elevation is too strong, particularly in valleys influenced by drainage circulations. Observations show little evidence of a “snow shadow,” so the neglect of the subgrid rain shadow does not produce an unrealistic simulation of the snow distribution. Summertime snow area, which is a proxy for land ice, is much larger than observed, mostly because of excessive snowfall but in some places because of a cold bias. Summertime snow water equivalent is far less than the observed thickness of glaciers because a 1-m upper bound on snow water is applied to the simulations and because snow transport by slides is neglected. The 1-m upper bound on snow water equivalent also causes an underestimate of seasonal snow water during late winter, compared with gridded station measurements. Potential solutions to these problems are discussed.
Surface Albedo Feedback Estimates for the AR4 Climate Models
Authors: Winton Michael 
Published: March 2006

Abstract
A technique for estimating surface albedo feedback (SAF) from standard monthly mean climate model diagnostics is applied to the 1% yr−1 carbon dioxide (CO2)-increase transient climate change integrations of 12 Intergovernmental Panel on Climate Change (IPCC) fourth assessment report (AR4) climate models. Over the 80-yr runs, the models produce a mean SAF at the surface of 0.3 W m−2 K−1 with a standard deviation of 0.09 W m−2 K−1. Relative to 2 × CO2 equilibrium run estimates from an earlier group of models, both the mean SAF and the standard deviation are reduced. Three-quarters of the model mean SAF comes from the Northern Hemisphere in roughly equal parts from the land and ocean areas. The remainder is due to Southern Hemisphere ocean areas. The SAF differences between the models are shown to stem mainly from the sensitivity of the surface albedo to surface temperature rather from the impact of a given surface albedo change on the shortwave budget.
Improved Analyses of Changes and Uncertainties in Sea Surface Temperature Measured In Situ since the Mid-Nineteenth Century: The HadSST2 Dataset
Authors: Rayner N. A. , Brohan P. , Parker D. E. , Folland C. K. , Kennedy J. J. , Vanicek M. , Ansell T. J. , Tett S. F. B. 
Published: March 2006

Abstract
A new flexible gridded dataset of sea surface temperature (SST) since 1850 is presented and its uncertainties are quantified. This analysis [the Second Hadley Centre Sea Surface Temperature dataset (HadSST2)] is based on data contained within the recently created International Comprehensive Ocean–Atmosphere Data Set (ICOADS) database and so is superior in geographical coverage to previous datasets and has smaller uncertainties. Issues arising when analyzing a database of observations measured from very different platforms and drawn from many different countries with different measurement practices are introduced. Improved bias corrections are applied to the data to account for changes in measurement conditions through time. A detailed analysis of uncertainties in these corrections is included by exploring assumptions made in their construction and producing multiple versions using a Monte Carlo method. An assessment of total uncertainty in each gridded average is obtained by combining these bias-correction-related uncertainties with those arising from measurement errors and undersampling of intragrid box variability. These are calculated by partitioning the variance in grid box averages between real and spurious variability. From month to month in individual grid boxes, sampling uncertainties tend to be most important (except in certain regions), but on large-scale averages bias-correction uncertainties are more dominant owing to their correlation between grid boxes. Changes in large-scale SST through time are assessed by two methods. The linear warming between 1850 and 2004 was 0.52° ± 0.19°C (95% confidence interval) for the globe, 0.59° ± 0.20°C for the Northern Hemisphere, and 0.46° ± 0.29°C for the Southern Hemisphere. Decadally filtered differences for these regions over this period were 0.67° ± 0.04°C, 0.71° ± 0.06°C, and 0.64° ± 0.07°C.
Modulation of Tropical Intraseasonal Oscillations by Ocean–Atmosphere Coupling
Authors: Rajendran K. , Kitoh A. 
Published: March 2006

Abstract
The impact of ocean–atmosphere coupling on the structure and propagation characteristics of 30–60-day tropical intraseasonal oscillations (TISOs) is investigated by analyzing long-term simulations of the Meteorological Research Institute coupled general circulation model (CGCM) and its stand-alone atmospheric general circulation model (AGCM) version forced with SSTs derived from the CGCM and comparing them with recent observation datasets [Global Precipitation Climatology Project (GPCP) precipitation, 40-yr European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA-40), and Reynolds SST]. Composite events of (i) eastward propagating Madden–Julian oscillations (MJOs) during boreal winter and (ii) northward propagating intraseasonal oscillations (NPISOs) during boreal summer, constructed based on objective criteria, show that the three-dimensional structure, amplitude, and speed of propagation, and the phase relationship among surface fluxes, SST, and convection, are markedly improved in the CGCM simulation.
Consistent with the frictional wave conditional instability of the second kind mechanism, successive development of low-level convergence to the east (north) of deep convection was found to be important for eastward (northward) propagation of MJO (NPISO). Complex interaction between large-scale dynamics and convection reveals the importance of atmospheric dynamics and suggests that they are intrinsic modes in the atmosphere where coupling is not essential for their existence. However, as in observations, realistic coupling in the CGCM is found to result in the evolution of TISOs as coupled modes through a coherent coupled feedback process. This acts as an amplifying mechanism for the existing propagating convective anomalies and plays an important modifying role toward a more realistic simulation of TISOs. In contrast, the simulated TISOs in its atmosphere-alone component lack many of the important features associated with their amplitude, phase, and life cycle. Thus, a realistic representation of the interaction between sea surface and the atmospheric boundary layer is crucial for a better simulation of TISOs.
The Effect of the MJO on the North American Monsoon*
Authors: Lorenz David J. , Hartmann Dennis L. 
Published: March 2006

Abstract
The effect of the Madden–Julian oscillation (MJO) in the eastern Pacific on the North American monsoon is documented using NCEP–NCAR reanalysis and daily mean precipitation data from 1958 to 2003. It is found that positive zonal wind anomalies in the eastern tropical Pacific lead to above-normal precipitation in northwest Mexico and Arizona from several days to over a week later. This connection between the tropical Pacific and monsoon precipitation appears to be limited to regions influenced by moisture surges from the Gulf of California as a similar connection does not exist for New Mexico precipitation. The evidence suggests that the MJO might affect monsoon precipitation by modulating the strength of low-level easterly waves off the coast of Mexico, which in turn triggers the development of a gulf surge.
Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor
Authors: Gu Ben J. , Wiley James S. 
Published: March 2006

AbstractMatrix metalloproteinase-9 (MMP-9) activity is required for inflammatory response, leukocyte recruitment, and tumor invasion. There is increasing evidence suggesting that the P2X7 receptor of mononuclear cells, which is activated by extracellular adenosine triphosphate (ATP), is involved in inflammatory responses. In this study, ATP caused a rapid release of MMP-9 and a moderate decrease in tissue inhibitor of metalloproteinase 1 (TIMP-1) release from human peripheral-blood mononuclear cells (PBMCs) over a 30-minute time course. The release was time- and dose-dependent and dissociated from ATP-induced cell death. BzATP, which is the most potent agonist for the P2X7 receptor, also caused a similar effect at a lower dosage. ATP-induced MMP-9 release was inhibited by the P2X7 receptor antagonists periodate oxidized ATP and KN-62, or by calcium chelators, as well as by a loss-of-function polymorphism in the P2X7 receptor, but not by brefeldin A, monensin, or cycloheximide, or by anti–tumor necrosis factor-α (TNF-α) or anti–interleukin-1β (IL-1β) monoclonal antibodies. Results from purified subsets of PBMCs showed monocytes were the major source for MMP-9 and TIMP-1 release, and ATP remained effective in purified monocyte and T-cell populations. These observations suggest a novel role for P2X7 as a pro-inflammatory receptor involved in rapid MMP-9 release and leukocyte recruitment.
PKCθ and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes
Authors: Hermann-Kleiter Natascha , Thuille Nikolaus , Pfeifhofer Christa , Gruber Thomas , Schäfer Michaela , Zitt Christof , Hatzelmann Armin , Schudt Christian , Leitges Michael , Baier Gottfried 
Published: March 2006

AbstractWe here investigate the crosstalk of PKC and PKA signaling during primary CD3+ T-lymphocyte activation using pharmacologic inhibitors and activators in combination with our established panel of PKC isotype–deficient mouse T cells in vitro. PKCθ and PKA inversely affect the CD3/CD28-induced IL-2 expression, whereas other PKC isotypes are dispensable in this signaling pathway. Gene ablation of PKCθ selectively results in a profound reduction of IL-2 production; however, complete abrogation of IL-2 production in these PKCθ–/– T cells was achieved only by simultaneous coactivation of the cAMP/PKA pathway in CD3+ T cells. Conversely, the reduced IL-2 production in PKC inhibitor–treated T cells can be rescued by inhibition of the cAMP/PKA pathway in wild-type but not in PKCθ–/– T cells. Mechanistically, the cAMP/PKA and PKCθ pathways converge at the level of NF-AT, as shown by DNA binding analysis. The combined increase in PKA and decrease in PKCθ activity leads to an enhanced inhibition of nuclear NF-AT translocation. This PKCθ/PKA crosstalk significantly affects neither the NF-κB, the AP-1, nor the CREB pathways. Taken together, this opposite effect between the positive PKCθ and the negative cAMP/PKA signaling pathways appears rate limiting for NF-AT transactivation and IL-2 secretion responses of CD3+ T lymphocytes.
Functional Abnormalities in the Neural Circuitry of Reading in Men with Nonsyndromic Clefts of the Lip or Palate
Authors: Goldsberry Grant , O'Leary Dan , Hichwa Rich , Nopoulos Peg 
Published: March 2006

Objective: The current study was designed to evaluate the neurobiology of reading in a group of men with nonsyndromic clefts of the lip or palate (NSCLP) compared with healthy controls by positron emission tomography. Design: Subjects included eight men with NSCLP compared with six healthy control men. By using radioactively labeled water (O15), regional brain blood flow was obtained during the performance of three simple reading tasks: reading unrelated words, reading unrelated sentences, and reading a story. Results: During each of the reading conditions, NSCLP subjects compared with healthy controls showed increased blood flow in areas previously reported to be involved in language processing and reading (inferior frontal lobe, cerebellum, and occipital lobe). The increased blood flow suggests a possible neural inefficiency. In contrast, when analyzing the brain regions involved in more complex language functioning (reading stories compared with reading only words), control subjects showed an increase in blood flow in a distributed neural circuit, whereas the NSCLP subjects showed a decrease in flow in these regions. Additionally, the NSCLP subjects had activation of several regions not activated in the healthy controls, suggesting a compensatory circuit used for this more complex reading task. Conclusions: These results indicate that subjects with NSCLP show abnormalities in the function of the distributed neural circuitry used for oral reading.
MELIORATION AND MAXIMIZATION OF REINFORCEMENT MINUS COSTS OF BEHAVIOR
Authors: Boelens Harrie 
Published: March 2006

Eight pigeons were exposed to independent concurrent schedules. Concurrent variable‐interval 60‐second variable‐interval 60‐second schedules were presented to one group of four subjects. Following baseline training, a limited hold was added to one of the schedules and the duration of the hold was decreased in successive conditions. Concurrent variable‐interval 120‐second variable‐interval 40‐second schedules were presented to another group of four subjects. These subjects were first exposed to decreasing durations of a limited hold in the variable‐interval 40‐second component. After replication of the baseline, a limited hold in the variable‐interval 120‐second component was decreased in duration. The initial durations of the holds were determined from the subjects' responding in the baseline conditions. A duration was chosen such that approximately 25% of the scheduled reinforcers would be canceled if responding remained unchanged.Approximate matching of time proportions and reinforcement proportions was observed when the limited hold was added to the variable‐interval 60‐second schedule and when the limited hold was added to the variable‐interval 40‐second schedule. Time proportions were less extreme than reinforcement proportions when the limited hold operated in a variable‐interval 120‐second schedule. Overall reinforcement rates tended to decrease with continued training in concurrent schedules with a limited hold. Absolute deviations from time matching also decreased. The results provide evidence against the principle of reinforcement maximization, and support Herrnstein and Vaughan's (1980) melioration hypothesis.