bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interaction of Nocturnal Low-Level Jets with Urban Geometries as Seen in Joint Urban 2003 Data
Authors: Lundquist Julie K. , Mirocha Jeffrey D. 
Published: February 2008

Abstract
Because accurate modeling of atmospheric flows in urban environments requires sophisticated representation of complex urban geometries, much work has been devoted to treatment of the urban surface. However, the importance of the larger-scale flow impinging upon the urban complex to the flow, transport, and dispersion within it and downwind has received less attention. Building-resolving computational fluid dynamics (CFD) models are commonly employed to investigate interactions between the flow and three-dimensional structures that make up the urban environment; however, such models are typically forced with simplified boundary conditions that fail to include important regional-scale phenomena that can strongly influence the flow within the urban complex and downwind. This paper investigates the interaction of an important and frequently occurring regional-scale phenomenon, the nocturnal low-level jet (LLJ), with urban-scale turbulence and dispersion in Oklahoma City, Oklahoma, using data from the Joint Urban 2003 (JU2003) field experiment. Two simulations of nocturnal tracer release experiments from JU2003 using Lawrence Livermore National Laboratory’s Finite-Element Model in 3 Dimensions and Massively Parallelized (FEM3MP) CFD model yield differing levels of agreement with the observations in wind speed, turbulence kinetic energy (TKE), and concentration profiles in the urban wake, approximately 750 m downwind of the central business district. Profiles of several observed turbulence parameters at this location indicate characteristics of both bottom-up and top-down boundary layers during each of the experiments. These data are consistent with turbulence production due to at least two sources, the complex flow structures of the urban area and the region of strong vertical wind shear occurring beneath the LLJs present each night. Strong LLJs occurred each night, but their structures varied considerably, resulting in significant differences in the magnitudes of the turbulence parameters observed during the two experiments. Because FEM3MP was forced only with an upwind velocity profile that did not adequately represent the LLJ, the downward propagation of TKE observed during the experiments was absent from the simulations. As such, the differing levels of agreement between the simulations and observations during the two experiments can, in part, be explained by their exclusion of this important larger-scale influence. The ability of the Weather Research and Forecast Model (WRF) to simulate accurate velocity fields during each night was demonstrated, and the use of regional-scale simulation data was identified as a promising approach for representing the effects of important regional-scale phenomena such as the LLJ on urban-scale simulations.
Testing IWC Retrieval Methods Using Radar and Ancillary Measurements with In Situ Data
Authors: Heymsfield Andrew J. , Protat Alain , Bouniol Dominique , Austin Richard T. , Hogan Robin J. , Delanoë Julien , Okamoto Hajime , Sato Kaori , van Zadelhoff Gerd-Jan , Donovan David P. , Wang Zhien 
Published: February 2008

Abstract
Vertical profiles of ice water content (IWC) can now be derived globally from spaceborne cloud satellite radar (CloudSat) data. Integrating these data with Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) data may further increase accuracy. Evaluations of the accuracy of IWC retrieved from radar alone and together with other measurements are now essential. A forward model employing aircraft Lagrangian spiral descents through mid- and low-latitude ice clouds is used to estimate profiles of what a lidar and conventional and Doppler radar would sense. Radar reflectivity Ze and Doppler fall speed at multiple wavelengths and extinction in visible wavelengths were derived from particle size distributions and shape data, constrained by IWC that were measured directly in most instances. These data were provided to eight teams that together cover 10 retrieval methods. Almost 3400 vertically distributed points from 19 clouds were used. Approximate cloud optical depths ranged from below 1 to more than 50. The teams returned retrieval IWC profiles that were evaluated in seven different ways to identify the amount and sources of errors. The mean (median) ratio of the retrieved-to-measured IWC was 1.15 (1.03) ± 0.66 for all teams, 1.08 (1.00) ± 0.60 for those employing a lidar–radar approach, and 1.27 (1.12) ± 0.78 for the standard CloudSat radar–visible optical depth algorithm for Ze &gt; −28 dBZe. The ratios for the groups employing the lidar–radar approach and the radar–visible optical depth algorithm may be lower by as much as 25% because of uncertainties in the extinction in small ice particles provided to the groups. Retrievals from future spaceborne radar using reflectivity–Doppler fall speeds show considerable promise. A lidar–radar approach, as applied to measurements from CALIPSO and CloudSat, is useful only in a narrow range of ice water paths (IWP) (40 &lt; IWP &lt; 100 g m−2). Because of the use of the Rayleigh approximation at high reflectivities in some of the algorithms and differences in the way nonspherical particles and Mie effects are considered, IWC retrievals in regions of radar reflectivity at 94 GHz exceeding about 5 dBZe are subject to uncertainties of ±50%.
A Simple Empirical Model for Estimating the Intensity Change of Tropical Cyclones after Landfall along the South China Coast
Authors: Wong Martin L. M. , Chan Johnny C. L. , Zhou Wen 
Published: February 2008

Abstract
The intensity change of past (1976–2005) tropical cyclones that made landfall along the south China coast (110.5°–117.5°E) is examined in this study using the best-track data from the Hong Kong Observatory. The change in the central pressure deficit (environmental pressure minus central pressure) and maximum surface wind after landfall are found to fit fairly well with an exponential decay model. Of the various potential predictors, the landfall intensity, landward speed, and excess of 850-hPa moist static energy have significant influence on the decay rates. Prediction equations for the exponential decay constants are developed based on these predictors.
Validation of Cloud Liquid Water Path Retrievals from SEVIRI Using One Year of CloudNET Observations
Authors: Roebeling R. A. , Deneke H. M. , Feijt A. J. 
Published: February 2008

Abstract
The accuracy and precision are determined of cloud liquid water path (LWP) retrievals from the Spinning Enhanced Visible and Infrared Imager (SEVIRI) on board Meteosat-8 using 1 yr of LWP retrievals from microwave radiometer (MWR) measurements of two CloudNET stations in northern Europe. The MWR retrievals of LWP have a precision that is superior to current satellite remote sensing techniques, which justifies their use as validation data. The Cloud Physical Properties (CPP) algorithm of the Satellite Application Facility on Climate Monitoring (CM-SAF) is used to retrieve LWP from SEVIRI reflectances at 0.6 and 1.6 μm. The results show large differences in the accuracy and precision of LWP retrievals from SEVIRI between summer and winter. During summer, the instantaneous LWP retrievals from SEVIRI agree well with those from the MWRs. The accuracy is better than 5 g m−2 and the precision is better than 30 g m−2, which is similar to the precision of LWP retrievals from MWR. The added value of the 15-min sampling frequency of Meteosat-8 becomes evident in the validation of the daily median and diurnal variations in LWP retrievals from SEVIRI. The daily median LWP values from SEVIRI and MWR are highly correlated (correlation &gt; 0.95) and have a precision better than 15 g m−2. In addition, SEVIRI and MWR reveal similar diurnal variations in retrieved LWP values. The peak LWP values occur around noon. During winter, SEVIRI generally overestimates the instantaneous LWP values from MWR, the accuracy drops to about 10 g m2, and the precision to about 30 g m−2. The most likely reason for these lower accuracies is the shortcoming of CPP, and similar one-dimensional retrieval algorithms, to model inhomogeneous clouds. It is suggested that neglecting cloud inhomogeneities leads to a significant overestimation of LWP retrievals from SEVIRI over northern Europe during winter.
Momentum Transfer within Canopies
Authors: Yi Chuixiang 
Published: February 2008

AbstractTo understand the basic characteristics of the observed S-shaped wind profile and the exponential flux profile within forest canopies, three hypotheses are postulated. The relationship between these fundamental profiles is well established by combining the postulated hypotheses with momentum equations. Robust agreements between theoretical predictions and observations indicate that the nature of momentum transfer within canopies can be well understood by combining the postulated hypotheses and momentum equations. The exponential Reynolds stress profiles were successfully predicted by the leaf area index (LAI) profile alone. The characteristics of the S-shaped wind profile were theoretically explained by the plant morphology and local drag coefficient distribution. Predictions of maximum drag coefficient were located around the maximum leaf area level for most forest canopies but lower than the maximum leaf area level for a corn canopy. A universal relationship of the Reynolds stress between the top and bottom of the canopy is predicted for all canopies. This universal relationship can be used to understand what percentage of the Reynolds stress at the top of canopy is absorbed by the whole canopy layer from the observed LAI values alone. All of these predictions are consistent with the conclusions from dimensional analysis and satisfy the continuity requirement of Reynolds stress, mean wind speed, and local drag coefficient at the top of canopy.
Sphingosine 1-phosphate–dependent trafficking of peritoneal B cells requires functional NFκB-inducing kinase in stromal cells
Authors: Kunisawa Jun , Gohda Masashi , Kurashima Yosuke , Ishikawa Izumi , Higuchi Morio , Kiyono Hiroshi 
Published: February 2008

Abstract
We previously reported that sphingosine 1-phosphate (S1P) regulates peritoneal B-cell trafficking and subsequent intestinal IgA production, but the underlying mechanisms remain obscure. We demonstrate here that nuclear factor κB–inducing kinase (NIK) is involved in the regulation of S1P-mediated trafficking of peritoneal B cells. Although peritoneal B cells from NIK-mutated alymphoplasia (aly) mice expressed type 1 S1P receptor (S1P1) at comparable levels and demonstrated normal migration toward S1P, aly peritoneal B cells showed decreased sensitivity to FTY720, an S1P1 modulator. NIK-mutated stromal cells showed decreased levels of adhesion molecules (VCAM-1 and ICAM-1) and increased CXCL13 expressions, leading to impaired ability to support S1P-mediated emigration, but not immigration, of peritoneal B cells. Therefore, aly peritoneal B cells exhibited normal S1P-mediated peritoneal B-cell trafficking from peritoneum to intestine for IgA production when they were transferred into severe combined immunodeficient or wild-type mice. However, S1P-mediated emigration of wild-type B cells from the aly peritoneal cavity was impaired without affecting their immigration from the blood. Further, transfer of wild-type stromal cells into the peritoneum restored S1P-mediated trafficking of aly peritoneal B cells. These findings suggest that NIK in stromal cells has a specific role in the regulation of S1P-mediated trafficking of peritoneal B cells.
How to quantify coughing: correlations with quality of life in chronic cough
Authors: Kelsall A. , Decalmer S. , Webster D. , Brown N. , McGuinness K. , Woodcock A. , Smith J. 
Published: February 2008

Different methods are used for quantifying coughing in sound recordings, but as yet no method has been shown to be more valid than any other. In the present study, the relationships between three different units of cough were examined and their ability to predict subjective ratings of cough and cough-related quality of life were evaluated.In total, 70 subjects (mean±sdage 55±11.7 yrs, 51 (73%) females) with chronic unexplained cough (median duration 4.8 yrs, interquartile range 2.5–10.1 yrs) performed fully ambulatory 24-h sound recordings, which were manually counted by trained observers and quantified by 1) explosive phases, 2) cough seconds and 3) cough epochs. Subjects also completed cough visual analogue scales (VAS) and the Leicester Cough Questionnaire (LCQ).All units of cough were strongly correlated; explosive phases and cough seconds correlated slightly more strongly than cough seconds with cough epochs or explosive phases with cough epochs. LCQ scores correlated moderately with explosive phases and seconds; epochs correlated slightly less well. Cough VAS scores showed a similar pattern.Explosive phases and seconds are interchangeable units of cough, moderately related to subjective measures and cough-related quality of life; epochs are a less satisfactory alternative.
Adenosine 5′-monophosphate in asthma: gas exchange and sputum cellular responses
Authors: Manrique H. A. , Gómez F. P. , Muñoz P. A. , Peña A. M. , Barberà J. A. , Roca J. , Rodríguez-Roisin R. 
Published: February 2008

Adenosine 5′-monophosphate (AMP) bronchoprovocation reproduces the lung function abnormalities that occur spontaneously during acute asthma and detects peripheral airway inflammation better than direct bronchoconstrictive agents. Pulmonary gas exchange disturbances may reflect changes in small airways related to airway inflammation rather than bronchoconstriction alone.The present authors investigated whether AMP induced a greater imbalance in the ventilation/perfusion ratio than methacholine (MCh), at an equivalent degree of bronchoconstriction, with and without salbutamol pre-medication. In total, 36 asthmatics were studied in three randomised, double-blind, crossover studies: 1) before and after AMP or MCh; 2) before and 30 min after salbutamol or placebo, followed by AMP; or 3) MCh challenge. Sputum was collected before and 4 h post-challenge.Compared with MCh, AMP provoked similar pulmonary gas exchange abnormalities at an equivalent degree of intense bronchoconstriction (forced expiratory volume in one second decrease of 28–44%). While salbutamol blocked AMP- or MCh-induced bronchoconstriction, arterial oxygen tension (Pa,O2) and alveolar–arterial oxygen tension difference (PA–a,O2) disturbances induced by AMP and MCh were only partially blocked (Pa,O2by 46 and 42%, respectively;PA–a,O2by 58 and 57%, respectively). Compared with MCh, AMP increased the percentage of neutrophils (mean±seincreased from 28±4% to 38±4%), but this increase did not occur after salbutamol pre-treatment.Both adenosine 5′-monophosphate and methacholine induced similar peripheral airway dysfunction. The fully inhibited adenosine 5′-monophosphate-induced neutrophilia with residual hypoxaemia observed after salbutamol treatment is probably related to β2-agonists acting on both bronchial and pulmonary circulation.
Genome-wide analysis of the rice and arabidopsis non-specific lipid transfer protein (nsLtp) gene families and identification of wheat nsLtp genes by EST data mining
Authors: Boutrot Freddy , Chantret Nathalie , Gautier Marie-Françoise 
Published: February 2008

Abstract

Background
Plant non-specific lipid transfer proteins (nsLTPs) are encoded by multigene families and possess physiological functions that remain unclear. Our objective was to characterize the complete nsLtp gene family in rice and arabidopsis and to perform wheat EST database mining for nsLtp gene discovery.

Results
In this study, we carried out a genome-wide analysis of nsLtp gene families in Oryza sativa and Arabidopsis thaliana and identified 52 rice nsLtp genes and 49 arabidopsis nsLtp genes. Here we present a complete overview of the genes and deduced protein features. Tandem duplication repeats, which represent 26 out of the 52 rice nsLtp genes and 18 out of the 49 arabidopsis nsLtp genes identified, support the complexity of the nsLtp gene families in these species. Phylogenetic analysis revealed that rice and arabidopsis nsLTPs are clustered in nine different clades. In addition, we performed comparative analysis of rice nsLtp genes and wheat (Triticum aestivum) EST sequences indexed in the UniGene database. We identified 156 putative wheat nsLtp genes, among which 91 were found in the 'Chinese Spring' cultivar. The 122 wheat non-redundant nsLTPs were organized in eight types and 33 subfamilies. Based on the observation that seven of these clades were present in arabidopsis, rice and wheat, we conclude that the major functional diversification within the nsLTP family predated the monocot/dicot divergence. In contrast, there is no type VII nsLTPs in arabidopsis and type IX nsLTPs were only identified in arabidopsis. The reason for the larger number of nsLtp genes in wheat may simply be due to the hexaploid state of wheat but may also reflect extensive duplication of gene clusters as observed on rice chromosomes 11 and 12 and arabidopsis chromosome 5.

Conclusion
Our current study provides fundamental information on the organization of the rice, arabidopsis and wheat nsLtp gene families. The multiplicity of nsLTP types provide new insights on arabidopsis, rice and wheat nsLtp gene families and will strongly support further transcript profiling or functional analyses of nsLtp genes. Until such time as specific physiological functions are defined, it seems relevant to categorize plant nsLTPs on the basis of sequence similarity and/or phylogenetic clustering.
A methodological framework to distinguish spectrum effects from spectrum biases and to assess diagnostic and screening test accuracy for patient populations: Application to the Papanicolaou cervical cancer smear test
Authors: Elie Caroline , Coste Joël ,   the French Society of Clinical Cytology Study Group
Published: February 2008

Abstract

Background
A spectrum effect was defined as differences in the sensitivity or specificity of a diagnostic test according to the patient's characteristics or disease features. A spectrum effect can lead to a spectrum bias when subgroup variations in sensitivity or specificity also affect the likelihood ratios and thus post-test probabilities. We propose and illustrate a methodological framework to distinguish spectrum effects from spectrum biases.

Methods
Data were collected for 1781 women having had a cervical smear test and colposcopy followed by biopsy if abnormalities were detected (the reference standard). Logistic models were constructed to evaluate both the sensitivity and specificity, and the likelihood ratios, of the test and to identify factors independently affecting the test's characteristics.

Results
For both tests, human papillomavirus test, study setting and age affected sensitivity or specificity of the smear test (spectrum effect), but only human papillomavirus test and study setting modified the likelihood ratios (spectrum bias) for clinical reading, whereas only human papillomavirus test and age modified the likelihood ratios (spectrum bias) for "optimized" interpretation.

Conclusion
Fitting sensitivity, specificity and likelihood ratios simultaneously allows the identification of covariates that independently affect diagnostic or screening test results and distinguishes spectrum effect from spectrum bias. We recommend this approach for the development of new tests, and for reporting test accuracy for different patient populations.
Substernal oxyphil parathyroid adenoma producing PTHrP with hypercalcemia and normal PTH level
Authors: Gurrado Angela , Marzullo Andrea , Lissidini Germana , Lippolis Agostino , Rubini Domenico , Lastilla Gaetano , Testini Mario 
Published: February 2008

Abstract

Background
Parathyroid adenoma is the most common cause of primary hyperparathyroidism. Preoperative serum calcium and intact-parathyroid hormone levels are the most useful diagnostic parameters that allow differentiating primary hyperparathyroidism from non-parathyroid-dependent hypercalcemia. Parathyroidectomy is the definitive treatment for primary hyperparathyroidism. Approximately 5% of patients who underwent parathyroidectomy present with persistent or recurrent hyperparathyroidism due to ectopic localization of the adenoma. Functioning oxyphil parathyroid adenoma is an uncommon histological form, seldom causing primary hyperparathyroidism. Parathyroid adenoma with hypercalcemia exhibiting normal parathyroid hormone level is rare. An incidence of 5% to 33% has been documented in the literature; no etiologic explanation has been given. In 1987, parathyroid-hormone-related peptide was isolated as a causative factor of humeral hypercalcemia of malignancy. The presence of parathyroid-hormone-related peptide in parathyroid tissue under normal and pathological conditions has been described in the literature; however, its role in causing hyperparathyroidism has not yet been defined.

Case presentation
We present a case of persistent hypercalcemia with a normal level of intact-parathyroid hormone due to a substernal parathyroid adenoma, treated with radioguided parathyroidectomy. The final histological diagnosis was oxyphil adenoma, positive for parathyroid-hormone-related peptide antigens.

Conclusion
In clinical practice, this atypical biochemical presentation of primary hyperparathyroidism should be considered in the differential diagnosis of hypercalcemia. The parathyroid-hormone-related peptide should be considered not only in the presence of malignancy.
Cars, corporations, and commodities: Consequences for the social determinants of health
Authors: Woodcock James , Aldred Rachel 
Published: February 2008

AbstractSocial epidemiologists have drawn attention to health inequalities as avoidable and inequitable, encouraging thinking beyond proximal risk factors to the causes of the causes. However, key debates remain unresolved including the contribution of material and psychosocial pathways to health inequalities. Tools to operationalise social factors have not developed in tandem with conceptual frameworks, and research has often remained focused on the disadvantaged rather than on forces shaping population health across the distribution. Using the example of transport, we argue that closer attention to social processes (capital accumulation and motorisation) and social forms (commodity, corporation, and car) offers a way forward. Corporations tied to the car, primarily oil and vehicle manufacturers, are central to the world economy. Key drivers in establishing this hegemony are the threat of violence from motor vehicles and the creation of distance through the restructuring of place. Transport matters for epidemiology because the growth of mass car ownership is environmentally unsustainable and affects population health through a myriad of pathways. Starting from social forms and processes, rather than their embodiment as individual health outcomes and inequalities, makes visible connections between road traffic injuries, obesity, climate change, underdevelopment of oil producing countries, and the huge opportunity cost of the car economy. Methodological implications include a movement-based understanding of how place affects health and a process-orientated integration of material and psychosocial explanations that, while materially based, contests assumptions of automatic benefits from economic growth. Finally, we identify car and oil corporations as anti-health forces and suggest collaboration with them creates conflicts of interest.