bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tecovirimat in the management of poxviruses: a narrative review of available evidence
Authors: Okesanya Olalekan John , Ogaya Jerico Bautista , Ogieuhi Ikponmwosa Jude , Ahmed Mohamed Mustaf , Ukoaka Bonaventure Michael , Jamgbadi Ojoisimi Franca , Shomuyiwa Deborah Oluwaseun , Eliseo Don Lucero-Prisno , Amisu Blessing Olawunmi , Adebusuyi Olakulehin , Chung William K. , Manirambona Emery , Idris Nimat Bola , De los Santos Janet Alexis A. 
Published: February 2025

Abstract

Introduction
Tecovirimat (TPOXX) is an effective antiviral medication recommended for treating smallpox and other Orthopoxvirus infections. With the rise in monkeypox (mpox) cases globally, there is an urgent need to explore therapeutic options to manage potential outbreaks.

Methodology
A literature search was conducted using keywords from Scopus and ClinicalTrials.gov. English studies from 2018 to 2024 were included.

Results
Ten studies assessing the effectiveness and safety of tecovirimat for poxvirus infections were evaluated, reporting diverse findings across different patient populations and study designs. Clinical trials have shown significant therapeutic potential. Various doses of tecovirimat were used in rabbit and mpox models. Early intervention slowed disease progression in vulnerable populations, such as people living with HIV (PLWHIV). Recovery times, virus eradication, and symptom relief varied among studies, but wider access and usage showed better clinical symptoms and tolerable side effects. Tecovirimat’s efficacy against circulating strains has been experimentally demonstrated.

Conclusion
Tecovirimat shows promise for treating poxvirus infections. Clinical trials are expected to provide more evidence-based findings to inform future therapeutic approaches and public health campaigns. Future research should explore tecovirimat’s potential in managing emerging poxvirus outbreaks, such as borealpox and mpox, to strengthen and promote public health.
The Aerial Witness and Infrastructures of Solidarity
Authors: Smith Angela 
Published: February 2025

Abstract
European social movements in solidarity with migrants have taken many forms, from maritime struggles at the edge of territory to antideportation protests in urban centers. Over the last five years, a new site of solidarity and struggle has emerged in the skies, with activist pilots and civil society organizations launching their own aerial surveillance operations to challenge the state's monopoly over the aerial view. The materiality of aviation and the legal and spatial systems that govern flying mean that the scope for political action and solidarity practices via the plane is always constrained. This article examines the affordances and limitations of aerial infrastructure as a vehicle for contesting state power and expressing solidarity with the agential movement/s of migrants.
Impairment of proteasome-associated deubiquitinating enzyme Uchl5/UBH-4 affects autophagy
Authors: Jha Sweta , Pispa Johanna , Holmberg Carina I. 
Published: February 2025

ABSTRACT
The autophagy–lysosomal pathway (ALP) and the ubiquitin–proteasome system (UPS) are the two major intracellular proteolytic systems that mediate protein turnover in eukaryotes. Although a crosstalk exists between these two systems, it is still unclear how UPS and ALP interact in vivo. Here, we investigated how impaired function of the proteasome-associated deubiquitinating enzyme (DUB) Uchl5/UBH-4 affects autophagy in human cells and in a multicellular organism. We show that downregulation of Uchl5 by siRNA reduces autophagy by partially blocking the fusion of autophagosomes with the lysosomes in HeLa cells, which is similar to a previously reported role of the proteasome-associated DUB Usp14 on autophagy. However, exposure of Caenorhabditis elegans to ubh-4 or usp-14 RNAi, or to their pharmacological inhibitors, results in diverse effects on numbers of autophagosomes and autolysosomes, without blocking the lysosomal fusion, in the intestine, hypodermal seam cells and the pharynx. Our results reveal that impairment of Uchl5/UBH-4 and Usp14 affects autophagy in a tissue context manner. A deeper insight into the interplay between UPS and ALP in various tissues in vivo has the potential to promote development of therapeutic approaches for disorders associated with proteostasis dysfunction.
Speed Matters: Limited Attention and Supply Chain Information Diffusion
Authors: Cen Ling , Hertzel Michael , Schiller Christoph 
Published: February 2025

We develop a measure of the speed of firm-level information diffusion, study how it is affected by limited attention, and examine its effect on real corporate decisions. Using local flu epidemics as exogenous attention shocks, we show that inattention from dual-covering analysts and cross-holding institutions reduces the speed of information diffusion from customer to supplier stock prices. We find that the speed of information diffusion along the supply chain affects the price feedback effect for corporate investment decisions and facilitates coordination between customers and suppliers. Our findings demonstrate that coattention from key market participants affects information efficiency and generates real economic outcomes. This paper was accepted by Camelia Kuhnen, finance. Funding: L. Cen acknowledges financial support from the Chinese University of Hong Kong and General Research Fund [Grant 14504920] from the Hong Kong Research Grants Council. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.00291 .
Long term cost-effectiveness analysis of IDegLira in the treatment of type 2 diabetes patients compared to GLP-1RA added to basal insulin after IDegLira entered the national reimbursement drug list in China
Authors: Xiao Dunming , Weng Junling , Zhang Lei , Xing Chang , Wei Yan , Chen Yingyao 
Published: February 2025

Background
Degludec insulin liraglutide injection is the world’s first and only approved basal insulin GLP-1RA injection in China (GLP-1RA stands for Glucagon-Like Peptide-1 Receptor Agonist. This study aimed to evaluate the long-term cost-effectiveness of IDegLira versus GLP-1RA added to basal insulin regimen (combined regimen) for patients with type 2 diabetes in China.

Methods
Based on the perspective of the health system, the study adopts the Swedish Institute for Health Economics diabetes cohort model. The baseline and clinical efficacy data in the model are from the EXTRA study. The cost includes glucose-lowering medication, background treatment cost, and complication treatment costs. The prices of IDegLira and GLP-1RA are based on the national medical insurance payment standards. Insulin adopts the national volume-based procurement average price. Other cost and utility data are sourced from published literature. The health outcome indicator is quality-adjusted life years (QALYs). The simulation time horizon is 30 years. The discounting rate of cost and health outcomes is 5%.

Results
In clinical output, IDegLira could reduce the cumulative incidence of various chronic complications in patients compared to the combined regimen. The eye diseases (background, proliferative retinopathy, macular edema, and visual loss) decreased by 24.4%, 41.1%, 18.9%, and 12.2%, respectively. Neuropathy decreased by 17.3%. Proteinuria and end-stage renal disease decreased by 25.9% and 17.6% respectively. Ischemic heart disease, heart failure, and myocardial infarction (stroke) decreased by 0.8%, 1.1%, and 4.7%, respectively. In the base-case analysis, IDegLira compared to the combined regimen shows an incremental cost of -34,254 CNY and an incremental QALYs of 0.436. Under the threshold of 1 times the per capita GDP of China in 2022 (85,698 CNY), IDegLira is a dominant scheme with lower cost and better health outcome. In probabilistic sensitivity analysis, the probability of IDegLira being cost-effective is 100%, indicating that the base-case analysis results are robust.

Conclusion
Compared with the combined regimen, the use of IDegLira for Chinese patients with type 2 diabetes can improve long-term health output, save medical costs, and is a dominant scheme.
Prevalence of prolonged transitional neonatal hypoglycemia and associated factors in Ethiopia: A systematic review and meta-analysis
Authors: Kebede Solomon Demis , Kassaw Amare , Aytenew Tigabu Munye , Agmas Kindu , Kefale Demewoz 
Published: February 2025

Introduction
Most neonates experience transient hypoglycemia, which typically responds well to treatment and is associated with a favorable prognosis. However, hypoglycemia persisting beyond 48 hours, termed prolonged transitional Neonatal hypoglycemia (PTNHG), can result in abrupt neuronal injury and long-term neurodevelopmental impairments. Identifying its prevalence and associated risk factors is critical to inform clinical practices and improve neonatal outcomes.

Methods
A weighted inverse-variance random-effects model was employed for the analysis. Heterogeneity among the studies was assessed using a forest plot, I2 statistics, and Egger’s test. Data extraction was conducted from May 20 to May 27, 2023, for studies published since 2020. A random blood sugar (RBS) concentration of <47 mg/dL measured 48–72 hours after birth was used to define PTNHG. Eight studies comprising a total of 3686 neonates were included in the analysis.

Results
The pooled prevalence of PTNHG was 19.71% (95% CI: 16.85–22.56) with substantial heterogeneity (I2 = 79.20%, P < 0.001). Subgroup analysis revealed that PTNHG prevalence was similar for studies with sample sizes >400 and ≤400, at 18% (95% CI: 15–22) and 21% (95% CI: 17–26), respectively. Similarly, prevalence estimates were comparable when using RBS thresholds of <47 mg/dL (21%; 95% CI: 16–27) and <40 mg/dL (18%; 95% CI: 15–22). Significant factors associated with PTNHG included preterm birth (AOR = 3.31; 95% CI: 2.57–4.04), hypothermia (AOR = 3.41; 95% CI: 2.19–4.62), being an infant of a diabetic mother (IDM) (AOR = 4.71; 95% CI: 2.15–7.26), delayed breastfeeding initiation beyond one hour (AOR = 3.26; 95% CI: 2.03–4.49), and pathological jaundice (AOR = 2.37; 95% CI: 1.91–2.84).

Conclusions
Nearly one-fifth of hospitalized neonates experienced PTNHG. Fortunately, most of the associated risk factors were modifiable. Prioritizing early breastfeeding initiation, particularly in cesarean section deliveries and IDM cases, and integrating PTNHG management into national NICU guidelines could significantly reduce the burden of neonatal hypoglycemia.

Trial registration
Prospero ID: CRD42023424953. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023424953.
Construction and validation of a predictive model for the risk of osteoporosis in patients with chronic kidney disease based on NHANES data
Authors: She Chunjie , Liu Hefeng 
Published: February 2025

Background
Chronic kidney disease (CKD) patients tend to exhibit a heightened susceptibility to osteoporosis owing to abnormalities in mineral and bone metabolism. The objective of this study was to develop and validate a nomogram for the prediction of osteoporosis risk in patients with CKD.

Methods
1498 patients diagnosed with CKD were enrolled from the National Health and Nutrition Examination Survey (NHANES) data spanning 2005–2010, 2013–2014, and 2017–2018. The dataset was randomly divided into a training set and a validation set in a ratio of 7:3. Utilizing the least absolute shrinkage and selection operator (LASSO) regression technique for predictor identification, followed by employing multivariate logistic regression based on the selected predictors to construct a nomogram. The performance of the prediction model was assessed using various metrics, including the area under the receiver operating characteristic curve (AUC), calibration curve, the Hosmer-Lemeshow test, and decision curve analysis (DCA).

Results
The construction of the nomogram was based on five predictors, namely age, height, weight, alkaline phosphatase (ALP), and history of fracture. The AUC of 0.8511 in the training set and 0.8184 in the validation set demonstrates robust discriminability. Furthermore, the excellent calibration and clinical applicability of the model have been thoroughly validated.

Conclusions
Our study suggests a nomogram, providing nephrologists with a convenient and effective tool for identifying individuals at high risk of osteoporosis and avoiding adverse outcomes related to CKD.
Characteristic analysis and surgical exploration for acetabular roof fractures: Multicenter retrospective cohort study
Authors: Zhang Ruipeng , Yin Yingchao , Chen Wei , Zhuang Yan , Fan Shicai , Yi Chengla , Lyu Gang , Zheng Longpo , Guo Xiaodong , Li Ming , Liu Guangyao , Hou Zhiyong , Zhang Yingze 
Published: February 2025

Background
Acetabular roof was a crucial structure for maintaining the stability of hip joint; however, its important role was not especially emphasized in the Letournel-Judet classification system. Acetabular roof was segmented into the roof column and roof wall in Three-column classification and fracture in this area alone was defined as A3 injury. The purpose of this study was to explore the characteristics and surgical strategy of A3 injury.

Methods
Patients with roof column/wall fractures received surgical management from January 2015 to 2019 January at nine level-1 trauma centers were retrospectively analyzed. Fracture data, surgical incision, operation time, blood loss, fracture healing and relevant complications were recorded to explore fracture characteristics and appropriate surgical strategy. Reduction quality was assessed based on postoperative radiographic examination. Merle d’Aubigné score was used to assess the functional outcome during the follow-up.

Results
A total of 60 patients met the inclusion criteria in this study. Mean operation time was 112.83±21.77 min, and mean intraoperative blood loss was 396.67±182.00 ml. Satisfactory reduction quality was obtained in 49 cases (81.67%). All fractures healed well at an average mean of 3.07 months. Satisfactory outcomes were obtained in 46 cases (76.67%), and mean Merle d’Aubigné score was 15.53±1.33 points at the final follow-up. Reduction quality and functional outcome showed no statistical difference in three subtypes (P<0.05). Reduction quality and functional outcome presented positive correlation in three subtype fractures (P<0.05). The complication rate was 11.67% (7/60) in this study.

Conclusion
The injury mechanism of A3 injury was the direct impaction from femoral head on acetabular roof. Reduction and fixation of A3 injury were technique demanding, and poor prognosis may be accompanied even treated by experienced surgeons. Appropriate surgical strategies (Table 5) based on fracture characteristics in three subtypes of A3 injury were the premise of accepted prognosis.
Individual differences in event experiences and psychosocial factors as drivers for perceived linguistic change following occupational major life events
Authors: Wirtz Mason A. , Pickl Simon , Pfenninger Simone E. 
Published: February 2025

Abstract
The aim of this study is to investigate both quantitatively and qualitatively the impact of career-related major life events (MLEs) on patterns of reported linguistic change across the lifespan, with an emphasis on how individual differences relate to differential patterns of MLE-related change. The occupational significant life events scrutinized here include entry into the workforce, job/career change, unemployment, and retirement. We analyzed survey data from 154 German-speaking adults in Austria who experienced (at least) one of these career-related MLEs. Results from Bayesian modeling showed that individual differences in event experiences (e.g., how stressful an MLE is perceived, how damaging an MLE is for one’s social status) alongside social factors such as varietal proficiency affect the degree of perceived MLE-related change in the sociolinguistic repertoire. Qualitatively, the thematic analysis revealed that facets of the linguistic marketplace seemed responsible for occupational MLE-related linguistic change, but also socio-affective drivers such as dialect pride and career-resultant shifts in one’s social networks and contact with other dialects.
Stability and convection in compressible partially ionized plasma layers: nonlinear and linear analysis
Authors: Chandel Vishal , Sunil  , Devi Reeta 
Published: February 2025

Abstract
The thermal convection of compressible, partially ionized plasma has been investigated using nonlinear and linear analyses across three boundary configurations. Nonlinear analysis was carried out via the energy method, while linear analysis was assessed using the normal mode method. For free-free boundaries, exact solutions were obtained, whereas, for rigid-rigid and rigid-free boundaries, the higher-order Galerkin-weighted residual method was employed for numerical results. The critical Rayleigh numbers for both analyses coincide, indicating global stability and confirming the absence of subcritical regions. The impact of collisional frequency on energy decay was quantified, revealing a significant effect on the decay rate, although it does not affect the Rayleigh number. The principle of exchange of stabilities was confirmed in the linear analysis. Compressibility delays the onset of convection. The critical Rayleigh numbers were computed as 986.267, 2,561.64, and 1,650.97 for the free–free, rigid–rigid, and rigid–free cases, respectively, demonstrating that plasma confined between rigid–rigid surfaces exhibits the highest thermal stability.
Hybrid modeling of piezoresistive pavement using finite element method and artificial neural network
Authors: Wang Tianling , Shi Jianwei , Wang Haopeng , Oeser Markus , Liu Pengfei 
Published: February 2025

Abstract
This study aims to establish a hybrid method combining the finite element method (FEM), the mechanical–electrical model, and a back-propagation artificial neural network (BP), to simulate the piezoresistive pavement. First, the tire-pavement FEM model with piezoresistive units was established considering the viscoelasticity of the pavement materials. Subsequently, the mechanical responses of the piezoresistive units under various tire and environmental loads were converted into electrical resistance outputs via the mechanical–electrical model. Finally, BP was trained using simulated data to address challenges associated with the back-calculation of tire loads. Results indicate that the electrical resistance of the piezoresistive unit in complete contact with the tire illustrates an overall rising trend as tire load increases, which is attributed to changes in contact stress. However, the adjacent piezoresistive units display an opposite trend, which can be used to determine the lateral position of the tires. Additionally, electrical resistance shows a non-linear decrease with increasing temperature. The single-hidden-layer BP with 13 neurons was validated to demonstrate higher accuracy compared to multi-hidden-layer BP. Moreover, the Genetic algorithm-optimized single-hidden-layer BP (GA-S-BP) shows further improved performance, achieving an MSE of 1.91 and an MAPE of 8.5%, and a low probability of underestimating tire loads. The GA-S-BP designed in this study can effectively predict tire loads within permissible levels to realize the function of piezoresistive pavement.
Efficacy and safety of repetitive peripheral magnetic stimulation in patients with lumbosacral radiculopathy during early postoperative rehabilitation period following microdiscectomy
Authors: Blokhina V. N. 
Published: February 2025

Background. The considerable number of surgical interventions for the treatment of discogenic lumbosacral radiculopathy(LSR) highlights the importance of optimizing complex post-surgical rehabilitation programs, particularly those incorporating innovative physiotherapeutic techniques. One of the modern and safe methods in physiotherapeutic rehabilitation is repetitive peripheral magnetic stimulation (rPMS).Objective: to evaluate the efficacy of a rehabilitation therapy that includes rPMS for patients with LSR during the early postoperative rehabilitation period following microdiscectomy.Material and methods. A prospective randomized comparative study involved 71 patients with LSR following microdiscectomy. On postoperative Day 7, the patients were randomly assigned to one of two groups. Group 1 (n=35) received a course of rPMS in addition to the standard rehabilitation therapy, while Group 2 (n=36) received only the standard treatment. Pain intensity was assessed using the visual analog scale, anxiety was evaluated using the state-trait anxiety inventory, and health-related quality of life was measured with the EuroQol-5D questionnaire.Results. On Day 21 of rehabilitation, a statistically significant difference (p=0.036) in pain intensity in the lower limb was observed between the two groups. In addition, a statistically significant difference (p=0.042) was revealed in the frequency distribution of trait anxiety severity. A statistically significant improvement in the frequency distribution of self-care level was observed in Group 1 between Days 7 and 21 (p<0.05).Conclusion. The clinical effects observed in terms of the regression of pain, improved sensory function, and psychological wellbeing were more pronounced in the group receiving rPMS. These findings suggest that rPMS incorporated into postoperative rehabilitation programs may serve as a valuable tool for enhancing patient recovery.
Estimación del costo del patrimonio para países del MILA durante el periodo 2018-2023 utilizando el modelo CAPM
Authors: Cortés Villafradez Raúl Alberto , Jiménez Méndez Edgar Ricardo 
Published: February 2025

Este trabajo tiene como objetivo estimar el costo de oportunidad del inversionista (Ke) para los países miembros del (MILA) en el periodo 2018-2023, usando el modelo Capital Asset Pricing Model (CAPM). Para esto fue fundamental realizar una revisión bibliográfica que justificara plenamente la forma de determinar el valor de los parámetros usados de cada una de las variables del modelo CAPM. Este es un estudio cuantitativo de tipo descriptivo. Los resultados sugieren que no siempre el CAPM es un modelo aplicable para calcular el costo del patrimonio, ya que los resultados del (Ke) de Colombia son negativos mientras que, los resultados de México, Chile y Perú convergen y son positivos.
Examining the Digital Literacy Levels of Syrian Refugee University Students
Authors: Akyol Cemal 
Published: February 2025

The aim of this study is to examine the digital literacy levels of Syrian refugee students studying at universities in Turkey across different variables. A descriptive survey model was used in the research. The sample of the study consisted of 184 Syrian university students studying at Selçuk University in Konya. The "Student Information Form" and the "Digital Literacy Scale" were used as data collection tools. In the analysis of the data, independent sample t-tests and ANOVA analysis were conducted using the SPSS software package.
According to the findings, the digital literacy levels of Syrian university students were found to be above average. The study concluded that there was no significant difference in digital literacy scores between male and female students. Additionally, the digital literacy scores of 4th-year students were found to be significantly higher than those of 1st-year students. An analysis of age groups revealed that the digital literacy scores of students aged 19-21 were significantly higher than those of students aged 25-27.