bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apology for myth in history
Authors: Экштут С.А. 
Published: April 2024

Автор исходит из понимания мифа, которое сформулировал А.Ф. Лосев. Бытование мифа в истории тесно связано с двумя внешне далеко отстающими друг от друга, но внутренне неразрывно соединенными между собой процессами – поиском исторической альтернативы и восхвалением на страницах Истории, которое именуется воздаянием славы. Личность может проснуться знаменитой на следующий день после совершения поступка, а может очень долго дожидаться всеобщего признания собственных заслуг, но так и не дождаться прижизненной славы. В этом признании или непризнании молвой заслуг и достоинств личности заключается одно из частных проявлений альтернативного характера исторического процесса. Существует весьма протяженный временной лаг между совершением выдающегося исторического деяния и его достойной исторической оценкой, которая выставляется потомством. Напряженная ситуация признания или непризнания заслуг перед Историей многократно усложняется альтернативным характером исторического процесса.
The author proceeds from the understanding of myth by A.F. Losev. The existence of myth in history is closely connected with two processes that are outwardly far removed from each other, but internally inextricably linked - the search for a historical alternative and praise on the pages of History, which is called the retribution of glory. A person may wake up famous the next day after committing an act, or he may wait a very long time for general recognition of his own merits, but never achieve lifetime fame. This recognition or non-recognition by rumor of the merits and merits of an individual lies one of the particular manifestations of the alternative nature of the historical process. There is a very long time lag between the commission of an outstanding historical act and its worthy historical assessment, which is given by posterity. The tense situation of recognition or non-recognition of merits to History is greatly complicated by the alternative nature of the historical process.
Study on bullet impact performance of the HATO-based explosives
Authors: Yang Jian , Li Hong-Bin , Jin Peng-Gang , Gao Zan , Ren Song-Tao , Jiang Xi-Bo , Zhang Wei-Jing 
Published: April 2024

In order to study the vulnerability of 1,1'-dihydroxy-5,5'-bistetrazole dihydroxylamine salt (HATO) based explosives, a comparative study of the bullet impact vulnerable characteristics of HATO-based explosives and HMX-based explosives were carried out by using the 12.7 mm bullet impact test method of the 700-group of the Military Mixed Explosives Formulation and Performance Test Methods. The results of the study indicate that due to the friction and impact sensitivities of the HATO and the HMX explosives are similar, and the bullet impact response degree and the safety performance of the HATO-based explosives and HMX-based explosives is equivalent too.
Cavitation fault diagnosis of centrifugal pump based on RIME-SDAE
Authors: Song Honghui , Sun Hui , Chen Ning 
Published: April 2024

In order to fully extract the fault characteristics of different cavitation fault states of centrifugal pumps, reduce the influence of hyperparameter settings on the identification and classification results of machine learning algorithms, this paper designs a network model based on the rime optimization algorithm (RIME) to improve the stacked denoising autoencoder (SDAE) network, which is named as RIME-SDAE. First of all, Singular Value Decomposition (SVD) is used to denoise the X, Y and Z signals of the triaxial vibration sensor, and time-domain, frequency-domain and time-frequency features are extracted to construct a signal feature set. Secondly, the three-dimensional feature indicators are analyzed and selected to be merged into the input dataset, and SDAE is trained with the RIME is used to determine the model parameters of SDAE synchronously. The feasibility of the proposed method is verified by the signals collected in the actual test, and the test results show that the accuracy on the test set reaches more than 98 %.
Phylogenetic identification of microbes from fermented botanicals used in gluten-free composite flour mixes
Authors: Oleghe Peace Omoikhudu , Akharaiyi Fred Coolborn , Ehis-Eriakha Chioma Bertha 
Published: April 2024

Phylogenetic information on microbial communities involved in fermenting botanicals has important implications for the food industry since it can provide a valuable perspective on the diversity, composition, and techno-functional properties and characteristics of the final product. Microbial phylogenetic analysis illustrates the evolutionary history of microbes through visual representational graphs (phylogenetic trees) showing the beginning and advancement of their assemblage.
In this study, we used molecular methods to determine the phylogenetic identities of microbes occurring in spontaneously fermented sweet potato, maize, and pigeon pea samples after a 72-hourly evaluation every 12 h. The sequences obtained were edited using the bioinformatics algorithm against similar sequences downloaded from the National Center for Biotechnology Information (NCBI) database using BLASTN and aligned using ClustalX. The neighbor-joining technique was applied to extrapolate the chronicle of the isolates evolution.
Molecular identification from the BLASTN results showed the following bacterial isolates: Lysinibacillus macrolides, Klebsiella pneumoniae, Lactococcus lactis, Providencia stuartii, Enterobacter cloacae, Limosilactobacillus fermentum, Lactobacillus fermentum, Staphylococcus edaphicus, and Bacillus flexus, as well as the following fungal isolates: Trichosporon asahii, Mucor irregularis, Cladosporium tenuissimum, and Aspergillus niger. The sequences obtained from the isolates produced an exact match with the NCBI non-redundant nucleotide (nr/nt) database. L. lactis had the highest percentage occurrence for bacteria (38.46%), while T. asahii and A. niger showed the highest occurrence for fungi (37.50%).
Identifying and characterizing the microorganisms involved in the fermentation process would allow optimizing fermentation conditions to enhance the quality and nutritional value of the final products.
Integrated assessment of groundwater contamination: A multi-marker approach for comprehensive water quality monitoring
Authors: Zehra Asima , Kaur Simranpreet , Gill J. P. S. , Singh Randhir 
Published: April 2024

ABSTRACT

This study investigated the presence of adenoviral markers (Library-Independent microbial source tracking tool) in the groundwater of Ludhiana, Punjab, India, a hitherto unexplored area. While deep aquifers post-chlorination were adenovirus free, shallow aquifers near farm wastewater pits exhibited human adenovirus and bovine adenovirus. Coliform-negative samples also harboured pathogens, highlighting the limitations of conventional indicators. Surface water displayed higher viral contamination, potentially impacting groundwater. The use of farm wastewater for irrigation and open pit disposal emerged as key contributors, advocating for sustainable wastewater management. Physiochemical and microbial analyses revealed variations across sites, emphasising regional and temporal variations. The weighted arithmetic water quality index ranged from good to very poor, with deep aquifers showing better quality than shallow ones. A novel approach incorporating graphical representations of adenovirus estimations alongside water quality index provided a more comprehensive understanding. Intriguingly, the study revealed the presence of coliforms irrespective of water quality grade, questioning its reliability as a sole indicator. Correlations between specific water quality grades and adenovirus types suggested targeted control measures. The lack of significant correlations between viral markers and conventional parameters in groundwater compared to surface water studies highlighted the unique dynamics of groundwater contamination.
Water–energy network provisioning services in Harare, Zimbabwe
Authors: Gandidzanwa Crecentia Pamidzai , Togo Muchaiteyi , Mawonde Albert 
Published: April 2024

ABSTRACT
Water-energy systems are interlinked. Energy is used in the treatment and pumping of water. Water is used to generate electricity. Effective and efficient water-energy network provisioning satisfies households' basic human needs. Most local authorities in developing countries have seen water and energy scarcity amid climate change. The research aims to understand the interlinkages of water-energy services and to develop integrated and innovative green solutions in line with sustainable development goals. This study explores water and energy network provisioning to promote an integrated approach to planning and managing service delivery in Harare, Zimbabwe. The paper also establishes how water and energy provisioning challenges have affected household activities. The study embraced a sequential mixed-methods approach. In-depth interviews were used to solicit information from relevant departments and focus group discussions from communities. A total of 314 questionnaires were administered to five communities based on five settlement classifications. The study hinges on the ‘collective action theory'. Findings revealed poor governance issues, lack of finance and public participation in water-energy service delivery. Integration of sectors and community participation can improve the provision of water -energy services and contribute to reducing carbon emissions through greening households.
Modelling effluent reuse in the pulp and paper industry to predict consequences on	conductivity
Authors: Prasse Stephanie , Huber Patrick , Ottenio Pascal , Fourest Eric 
Published: April 2024

ABSTRACT

The objective of this study was to assess, through simulation, conductivity variations in pulp and paper circuits when recycling waste water treatment plant (WWTP) effluent with a view to reducing fresh water use in a tissue mill. WWTP effluent was recycled in the process for different uses. A PS2000 digital model coupled with the PHREEQC chemical simulation engine was used to identify and quantify the main sources of conductivity: caustic soda, sodium bisulphite and acetate production through anaerobic microbial activity. Recycling WWTP effluent enables fresh water uptake to be reduced by 50% when used for pulp dilution or white water, by 81% when used in paper machine showers, and up to 96% for all uses combined. As fresh water use decreases, circuit closure increases along with, consequently, COD and conductivity. COD build-up can be controlled by best available techniques application. Recycling WWTP effluent has a strong impact on conductivity. However, the impact of high conductivity levels on additives performance is limited in the case of the mill studied. Acetate concentration could be controlled by better agitation of tanks or the introduction of air by pumps. Furthermore, limiting acetate production can reduce the need for caustic soda to control the pH.
Mechanism Research of PZD Inhibiting Lung Cancer Cell Proliferation, Invasion,
and Migration based on Network Pharmacology
Authors: Feng Fan , Hu Ping , Peng Lei , Chen Jun , Tao Xingkui 
Published: April 2024

Background:
A classic Chinese medicine decoction, Pinellia ternata (Thunb.) Breit.-Zingiber officinale
Roscoe (Ban-Xia and Sheng-Jiang in Chinese) decoction (PZD), has shown significant therapeutic
effects on lung cancer.

Objective:
This study aimed to explore and elucidate the mechanism of action of PZD on lung cancer using
network pharmacology methods.

Methods:
Active compounds were selected according to the ADME parameters recorded in the TCMSP database.
Potential pathways related to genes were identified through GO and KEGG analysis. The compoundtarget
network was constructed by using Cytoscape 3.7.1 software, and the core common targets were obtained
by protein-protein interaction (PPI) network analysis. Batch molecular docking of small molecule compounds
and target proteins was carried out by using the AutoDock Vina program. Different concentrations of
PZD water extracts (10, 20, 40, 80, and 160 μg/mL) were used on lung cancer cells. Moreover, MTT and
Transwell experiments were conducted to validate the prominent therapeutic effects of PZD on lung cancer
cell H1299.

Conclusion:
PZD could inhibit the cell proliferation, migration, and invasion of NCI-H1299 cells partially
through the PI3K/AKT signaling pathway. These findings suggested that PZD might be a potential treatment
strategy for lung cancer patients.

Results:
A total of 381 components in PZD were screened, of which 16 were selected as bioactive compounds.
The compound-target network consisting of 16 compounds and 79 common core targets was constructed.
MTT experiment showed that the PZD extract could inhibit the cell proliferation of NCI-H1299
cells, and the IC50 was calculated as 97.34 ± 6.14 μg/mL. Transwell and wound-healing experiments showed
that the PZD could significantly decrease cell migration and invasion at concentrations of 80 and 160 μg/mL,
respectively. The in vitro experiments confirmed that PZD had significant therapeutic effects on lung cancer
cells, mainly through the PI3K/AKT signaling pathway.
Survival of Patients with Primary Brain Tumor: A Data Analysis of 10 Years
Authors: Verma Shristy , Malviya Rishabha , Uniyal Prerna 
Published: April 2024

Background::
The prognosis for primary brain tumors, like other CNS tumors, can vary greatly
based on several factors, such as treatment history, age and gender at diagnosis, ethnic background, and treatment
plan.

Materials and Method::
A systematic review approach was used to gather relevant data from PubMed, ScienceDirect,
Google Scholar, and other sources.

Results::
The survival rate of primary brain tumors and other CNS tumors appears to be correlated with several
variables, including treatment history, gender, age at evaluation, race/ethnicity, and treatment regimen; this
emphasizes the importance of routinely updating epidemiological data on primary brain tumors to advance
biological understanding.

Conclusion::
This study draws attention to the variations in the median survival times of the various kinds of
primary brain tumors, with oligodendroglioma having the longest median survival time (199 months, or approximately
16.6 years) and glioblastoma having the shortest (8 months).
The Renoprotective and Anti-Inflammatory Effects of Human Urine-Derived Stem Cells on Acute Kidney Injury Animals
Authors: Kuang Yuanyuan , Fan Chenyu , Long Xiaojun , Zheng Jiajia , Zeng Yunsi , Wei Yuhui , Zhang Jiasheng , Yu Shuangjin , Chen Tong , Ruan Hehuan , Wang Yi , Na Ning , Zhou Yiming , Qiu Jiang 
Published: April 2024

Background:
Acute Kidney Injury (AKI) is defined as a sudden loss of kidney function,
which is often caused by drugs, toxins, and infections. The large spectrum of AKI implies diverse
pathophysiological mechanisms. In many cases, AKI can be lethal, and kidney replacement
therapy is frequently needed. However, current treatments are not satisfying. Developing novel
therapies for AKI is essential. Adult stem cells possess regenerative ability and play an important
role in medical research and disease treatment.

Methods:
In this study, we isolated and characterized a distinct human urine-derived stem cell,
which expressed both proximal tubular cell and mesenchymal stem cell genes as well as certain
unique genes.

Results:
It was found that these cells exhibited robust protective effects on tubular cells and anti-
inflammatory effects on macrophages in vitro. In an ischemia-reperfusion-induced acute kidney
injury NOD-SCID mouse model, transplantation of USCs significantly protected the kidney morphology
and functions in vivo.

Conclusion:
In summary, our results highlighted the effectiveness of USCs in protecting from
PTC injury and impeding macrophage polarization, as well as the secretion of pro-inflammatory
interleukins, suggesting the potential of USCs as a novel cell therapy in AKI.
SmartLipids: Ushering in a New Era of Lipid Nanoparticles for Drug
Delivery
Authors: Sharma Bhawna , Chauhan Iti , Kumar Gaurav , Tiwari Raj Kumar 
Published: April 2024

Abstract:
In the realm of drug delivery, lipid nanoparticles have emerged as versatile carriers, offering
enhanced encapsulation, protection, and targeted delivery of therapeutic agents. Among these
innovative systems, SmartLipids stands out as a groundbreaking advancement, representing the latest
generation of lipid nanoparticles. Characterized by their unique "chaotic" and disordered particle
matrix structure, SmartLipids exhibit remarkable properties that set them apart from conventional
drug delivery systems. This comprehensive review delves into the intricate world of SmartLipids,
unraveling their distinctive features and exploring their immense potential in the field of drug delivery.
It meticulously outlines their production methods, shedding light on the solvent-free, highpressure
homogenization technique that ensures biocompatibility and safety. The review meticulously
examines the physicochemical characterization of SmartLipids, providing insights into their particle
size, morphology, and encapsulation efficiency. It further delves into their in vitro and in vivo
performance, highlighting their ability to enhance drug solubility, permeability, and bioavailability.
The study collectively underscores the versatility and customizable nature of SmartLipids, emphasizing
their suitability for a wide range of drug delivery applications. From encapsulating hydrophilic,
lipophilic, and amphiphilic compounds to tailoring specific release profiles, SmartLipids offer
a remarkable degree of flexibility in drug delivery strategies.
Implementation of Omics Approaches in Unravelling the Potency of Cordyceps militaris in Drug Discovery
Authors: Thoe Ewen Se , Chia Yoke Yin , Tang Yin Quan , Chamyuang Sunita 
Published: April 2024

:
Natural products have long garnered the interest of scientific communities as they have
proven to be an effective therapeutic resource that paved the path for medicinal research and drug
development. Among them, Cordyceps militaris is an entomopathogenic caterpillar fungus with a
renowned history of being utilized as a medicinal remedy for centuries in Eastern civilizations. The
number of pharmacological functions reported by this specific fungus resulted in continuous efforts
to unravel new effective bioactive compounds and their corresponding mechanism of action. As time
progresses, computational techniques become the forefront of genomic and proteomic analysis, besides
acting as a platform for integrating various up-to-date multidisciplinary data sources. This review
briefly introduces Cordyceps militaris alongside the latest known biologically active compounds
and their respective therapeutic potential. The need to implement computational applications
to cope with the continuous phytochemical evolution of Cordyceps militaris will be illustrated.
Moreover, many databases, mathematical algorithms, or sourcing tools that could benefit data visualization,
dissemination, and interpretation aligned to fungal-based research are enumerated, in addition
to describing some of the broad discoveries relative to Cordyceps militaris in the past. In conclusion,
using advanced computational technology may be the foundation to leverage natural product
discovery about Cordyceps militaris and contribute to future mass production of this fungus for
commercial purposes in the world pharmaceutical industry.
The Secure Therapeutic Effects of Recently Developed Antipsychotic Drugs and Updated Neural Networks in Schizophrenia
Authors: Werner Felix-Martin , Coveñas Rafael 
Published: April 2024

Introduction:
Schizophrenia and schizoaffective disorder are treated in most
cases with antipsychotic drugs of the second generation. These drugs block dopaminergic
and serotonergic receptors, i.e., D2 and 5-HT2A receptors, and cause different adverse
effects, for example, movement disturbances of the extrapyramidal system and adverse
effects of vital parameters and of the heart. These drugs treat positive symptoms in
schizophrenia and, to a lesser extent, negative symptoms. This review presents the development
of newer antipsychotic drugs.

Methods/Material:
References were taken from PubMed after using the following keywords:
schizophrenia, schizoaffective disorder, antipsychotic drug, neurotransmitter and
neuropeptide. Among these newer antipsychotic drugs are cariprazine, brexipiprazole
and lumateperone, which exert a partial agonistic effect at D2 and 5-HT2A receptors, pimavanserin,
a 5-HT2A receptor antagonist which treats negative symptoms in schizophrenia
as an add-on therapy, olanzapine combined with samidorphan, which reduces
weight gain, and M4 or M1 receptor agonists, for example, xanomeline with an antipsychotic
effect combined with trospium, an anticholinergic drug. Neural networks were
updated in order to deduce the antipsychotic mechanism of action of newer antipsychotic
drugs, especially xanomeline.

Results:
The newer antipsychotic drugs cariprazine, brexipiprazole and lumateperone
show antipsychotic, antimanic and anti-depressive effects, however, the efficacy on psychotic
symptoms in long-term treatment has not yet been examined. Pimavanserin reduces
negative symptoms in schizophrenia as an additional pharmacotherapy to treat this
disorder. Olanzapine combined with samidorphan exerts good antipsychotic effects and
reduces weight gain. The new antipsychotic drug xanomeline, the antipsychotic effect of
which is quite different from the antidopaminergic effect, treats positive and negative
symptoms in schizophrenia. Its mechanism of action was deduced from the neural networks
presented. The long-term efficacy should still be examined.

Conclusion:
This review is focused on newer antipsychotic drugs. The long-term efficacy
of cariprazine, brexipiprazole and lumateperone in the treatment of schizophrenia
should be examined furthermore. Neural networks in the brain areas involved in schizophrenia
should be examined and updated furthermore. Newer antipsychotic drugs, for
example, xanomeline, an M4 or M1 receptor agonist, which has been combined with trospium,
an anticholinergic drug, the mechanism of action of which can be derived from
the neural network suggested in this review.