bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of COVID-19 contagion in cohabitants and family members on mental health and academic self-efficacy among university students in Sweden: a prospective longitudinal study
Authors: Andersson Claes , Berman Anne H , Lindfors Petra , Bendtsen Marcus 
Published: March 2024

ObjectiveThis study used causal inference to estimate the longitudinal effects of contagion in cohabitants and family members on university students’ mental health and academic self-efficacy during the COVID-19 pandemic.DesignA prospective longitudinal study including a baseline online measurement in May 2020, and online follow-ups after 5 months and 10 months. Participants were recruited through open-access online advertising.SettingPublic universities and university colleges in Sweden.ParticipantsThe analytical sample included 2796 students.Outcome measuresContagion in cohabitants and in family members was assessed at baseline and at the 5-month follow-up. Mental health and academic self-efficacy were assessed at the 5-month and 10-month follow-ups.ResultsMild symptoms reported in cohabitants at baseline resulted in negative mental health effects at follow-up 5 months later, and mild baseline symptoms in family members resulted in negative effects on academic self-efficacy at follow-ups both 5 and 10 months later.ConclusionsNotwithstanding the lack of precision in estimated effects, the findings emphasise the importance of social relationships and the challenges of providing students with sufficient support in times of crisis.
Vasoactive drugs for the treatment of pulmonary hypertension associated with interstitial lung diseases: a systematic review
Authors: Bongiovanni Gabriele , Tonutti Antonio , Stainer Anna , Nigro Mattia , Kellogg Dean L , Nambiar Anoop , Gramegna Andrea , Mantero Marco , Voza Antonio , Blasi Francesco , Aliberti Stefano , Amati Francesco 
Published: March 2024

ObjectivesVasoactive drugs have exhibited clinical efficacy in addressing pulmonary arterial hypertension, manifesting a significant reduction in morbidity and mortality. Pulmonary hypertension may complicate advanced interstitial lung disease (PH-ILD) and is associated with high rates of disability, hospitalisation due to cardiac and respiratory illnesses, and mortality. Prior management hinged on treating the underlying lung disease and comorbidities. However, the INCREASE trial of inhaled treprostinil in PH-ILD has demonstrated that PH-ILD can be effectively treated with vasoactive drugs.MethodsThis comprehensive systematic review examines the evidence for vasoactive drugs in the management of PH-ILD.ResultsA total of 1442 pubblications were screened, 11 RCTs were considered for quantitative synthesis. Unfortunately, the salient studies are limited by population heterogeneity, short-term follow-up and the selection of outcomes with uncertain clinical significance.ConclusionsThis systematic review underscores the necessity of establishing a precision medicine-oriented strategy, directed at uncovering and addressing the intricate cellular and molecular mechanisms that underlie the pathophysiology of PH-ILD.PROSPERO registration numberCRD42023457482.
Risk factors for pulmonary tuberculosis recurrence, relapse and reinfection: a systematic review and meta-analysis
Authors: Vega Victor , Cabrera-Sanchez Javier , Rodríguez Sharon , Verdonck Kristien , Seas Carlos , Otero Larissa , Van der Stuyft Patrick 
Published: March 2024

BackgroundThe rate of pulmonary tuberculosis (TB) recurrence is substantial. Identifying risk factors can support the development of prevention strategies.MethodsWe retrieved studies published between 1 January 1980 and 31 December 2022 that assessed factors associated with undifferentiated TB recurrence, relapse or reinfection. For factors reported in at least four studies, we performed random-effects meta-analysis to estimate a pooled relative risk (RR). We assessed heterogeneity, risk of publication bias and certainty of evidence.ResultsWe included 85 studies in the review; 81 documented risk factors for undifferentiated recurrence, 17 for relapse and 10 for reinfection. The scope for meta-analyses was limited given the wide variety of factors studied, inconsistency in control for confounding and the fact that only few studies employed molecular genotyping. Factors that significantly contributed to moderately or strongly increased pooled risk and scored at least moderate certainty of evidence were: for undifferentiated recurrence, multidrug resistance (MDR) (RR 3.49; 95% CI 1.86 to 6.53) and fixed-dose combination TB drugs (RR 2.29; 95% CI 1.10 to 4.75) in the previous episode; for relapse, none; and for reinfection, HIV infection (RR 4.65; 95% CI 1.71 to 12.65). Low adherence to treatment increased the pooled risk of recurrence 3.3-fold (95% CI 2.37 to 4.62), but the certainty of evidence was weak.ConclusionThis review emphasises the need for standardising methods for TB recurrence research. Actively pursuing MDR prevention, facilitating retention in treatment and providing integrated care for patients with HIV could curb recurrence rates. The use of fixed-dose combinations of TB drugs under field conditions merits further attention.PROSPERO registration numberCRD42018077867.
Evaluation of the Role of AXL in Fusion-positive Pediatric Rhabdomyosarcoma Identifies the Small-molecule Inhibitor Bemcentinib (BGB324) as Potent Chemosensitizer
Authors: Danielli Sara G. , Wurth Jakob , Morice Sarah , Kisele Samanta , Surdez Didier , Delattre Olivier , Bode Peter K. , Wachtel Marco , Schäfer Beat W. 
Published: March 2024

Abstract
Rhabdomyosarcoma (RMS) is a highly aggressive pediatric cancer with features of skeletal muscle differentiation. More than 80% of the high-risk patients ultimately fail to respond to chemotherapy treatment, leading to limited therapeutic options and dismal prognostic rates. The lack of response and subsequent tumor recurrence is driven in part by stem cell–like cells, the tumor subpopulation that is enriched after treatment, and characterized by expression of the AXL receptor tyrosine kinase (AXL). AXL mediates survival, migration, and therapy resistance in several cancer types; however, its function in RMS remains unclear. In this study, we investigated the role of AXL in RMS tumorigenesis, migration, and chemotherapy response, and whether targeting of AXL with small-molecule inhibitors could potentiate the efficacy of chemotherapy. We show that AXL is expressed in a heterogeneous manner in patient-derived xenografts (PDX), primary cultures and cell line models of RMS, consistent with its stem cell–state selectivity. By generating a CRISPR/Cas9 AXL knock-out and overexpressing models, we show that AXL contributes to the migratory phenotype of RMS, but not to chemotherapy resistance. Instead, pharmacologic blockade with the AXL inhibitors bemcentinib (BGB324), cabozantinib and NPS-1034 rapidly killed RMS cells in an AXL-independent manner and augmented the efficacy of the chemotherapeutics vincristine and cyclophosphamide. In vivo administration of the combination of bemcentinib and vincristine exerted strong antitumoral activity in a rapidly progressing PDX mouse model, significantly reducing tumor burden compared with single-agent treatment. Collectively, our data identify bemcentinib as a promising drug to improve chemotherapy efficacy in patients with RMS.
Association of the Intensive Blood Pressure Target and Cardiovascular Outcomes in the Population With Chronic Kidney Disease: A Retrospective Study in Korea
Authors: Yoon Soo‐Young , Kong Ji Yoon , Jeong Su Jin , Kim Jin Sug , Hwang Hyeon Seok , Jeong Kyunghwan 
Published: March 2024

Background
Recently, the target systolic blood pressure (BP) <120 mm Hg was suggested in the population with chronic kidney disease. We aimed to determine the applicability of intensified BP and to assess the incidence of cardiovascular disease (CVD) in the population with chronic kidney disease.

Methods and Results

Participants who were >20 years old and had estimated glomerular filtration rate 15 to 60 mL/min per 1.73 m
2
during 2009 to 2011 were included from the database of Korean National Health Insurance Service and were followed up to 2018. Participants were categorized by BP as <120/80 mm Hg; 120 to 129/<80 mm Hg; 130 to 139/80 to 89 mm Hg; ≥140/90 mm Hg. The primary outcome was CVD risk and the secondary outcomes were all‐cause mortality and progression to end‐stage renal disease followed by subgroup analysis. Among the 45 263 adults with chronic kidney disease, 5196 CVD events were noted. In Cox regression analysis, higher BP was associated with a higher risk for CVD (hazard ratio [HR], 1.15 [95% CI, 1.12–1.19];
P
for trend <0.001), end‐stage renal disease (HR, 1.29 [95% CI, 1.22–1.37];
P
for trend <0.001), and all‐cause mortality (HR, 1.09 [95% CI, 1.06–1.13];
P
for trend <0.001) than BP <120/80 mm Hg. In subgroup analysis, the association between BP and CVD showed a different trend in participants taking antihypertensives compared with those not using antihypertensive drugs. When comparing BP‐treated individuals to untreated individuals, a significant interaction in the association between BP categories and end‐stage renal disease was observed.

Conclusions
The new intensive BP target proposed by 2021 Kidney Disease: Improving Global Outcomes should be applied to patients with chronic kidney disease in a personalized and advisory manner.
Integrative Assessment of Cardiopulmonary Fitness Using Cardiopulmonary Exercise Test With Supine Bicycle Echocardiography in Patients Presenting Dyspnea
Authors: Park Jiesuck , Ahn Houng‐Beom , Choi Hyejung , Choi Hong‐Mi , Hwang In‐Chang , Yoon Yeonyee E. , Cho Goo‐Yeong 
Published: March 2024

Background
Cardiopulmonary exercise test (CPET) with supine bicycle echocardiography (SBE) enables comprehensive physiologic assessment during exercise. We characterized cardiopulmonary fitness by integrating CPET‐SBE parameters and evaluated its prognostic value in patients presenting with dyspnea.

Methods and Results

We retrospectively reviewed 473 consecutive patients who underwent CPET‐SBE for dyspnea evaluation. A dimensionality reduction process was applied, transforming 24 clinical and CPET‐SBE parameters into a 2‐dimensional feature map, followed by patient clustering based on the data distribution. Clinical and exercise features were compared among the clusters in addition to the 5‐year risk of clinical outcome (a composite of cardiovascular death and heart failure hospitalization). Maximum exercise effort (
R
>1) was achieved in 95% of cases. Through dimensionality reduction, 3 patient clusters were derived: Group 1 (n=157), 2 (n=104), and 3 (n=212). Median age and female proportion increased from Group 1 to 2, and 3, although resting echocardiography parameters showed no significant abnormalities among the groups. There was a worsening trend in the exercise response from Group 1 to 2 and 3, including left ventricular diastolic function, oxygen consumption, and ventilatory efficiency. During follow‐up (median 6.0 [1.6–10.4] years), clinical outcome increased from Group 1 to 2 and 3 (5‐year rate 3.7% versus 7.0% versus 13.0%, respectively; log‐rank
P
=0.02), with higher risk in Group 2 (hazard ratio, 1.94 [95% CI, 0.52–7.22]) and Group 3 (3.92 [1.34–11.42]) compared with Group 1.

Conclusions
Comprehensive evaluation using CPET‐SBE can reveal distinct characteristics of cardiopulmonary fitness in patients presenting with dyspnea, potentially enhancing outcome prediction.
Geometric deep learning for diffusion MRI signal reconstruction with continuous samplings (DISCUS)
Authors: Ewert Christian , Kügler David , Stirnberg Rüdiger , Koch Alexandra , Yendiki Anastasia , Reuter Martin 
Published: March 2024

Abstract
Diffusion-weighted magnetic resonance imaging (dMRI) permits a detailed in-vivo analysis of neuroanatomical microstructure, invaluable for clinical and population studies. However, many measurements with different diffusion-encoding directions and possibly b-values are necessary to infer the underlying tissue microstructure within different imaging voxels accurately. Two challenges particularly limit the utility of dMRI: long acquisition times limit feasible scans to only a few directional measurements, and the heterogeneity of acquisition schemes across studies makes it difficult to combine datasets. Left unaddressed by previous learning-based methods that only accept dMRI data adhering to the specific acquisition scheme used for training, there is a need for methods that accept and predict signals for arbitrary diffusion encodings. Addressing these challenges, we describe the first geometric deep learning method for continuous dMRI signal reconstruction for arbitrary diffusion sampling schemes for both the input and output. Our method combines the reconstruction accuracy and robustness of previous learning-based methods with the flexibility of model-based methods, for example, spherical harmonics or SHORE. We demonstrate that our method outperforms model-based methods and performs on par with discrete learning-based methods on single-, multi-shell, and grid-based diffusion MRI datasets. Relevant for dMRI-derived analyses, we show that our reconstruction translates to higher-quality estimates of frequently used microstructure models compared to other reconstruction methods, enabling high-quality analyses even from very short dMRI acquisitions.
A catalogue of Indian Gelechiidae Stainton, 1854 (Lepidoptera: Gelechioidea)
Authors: D NANDHINI , R. SHASHANK P. , JOSHI RAHUL , REDDY KARTHIK M. 
Published: March 2024

We present an annotated catalogue of the Lepidoptera family Gelechiidae of India, comprising 351 species in 80 genera, encompassing seven subfamilies. The Indian fauna represents 7.47% of global gelechiid species diversity (i.e., 4,700 species in 500 genera). Among the seven subfamilies, Dichomeridinae is the best represented (122 species in four genera), followed by Gelechiinae (76 species in 38 genera), Anacampsinae (70 species in 16 genera), Thiotrichinae (49 species in five genera), Anomologinae (26 species in nine genera), Apatetrinae (seven species in seven genera), and Physoptilinae (single species). Information on type locality, type repository, synonyms, geographical distribution, hosts, natural enemies, and references to illustrations are provided. We also reviewed the history of descriptive work on the Gelechiidae of India, and resolved ambiguities regarding the current status of some species.
Fairy moths of the genus Nemophora Hoffmannsegg, 1798 (Lepidoptera: Adelidae) from Myanmar, Thailand, Laos, Cambodia and Vietnam
Authors: KOZLOV MIKHAIL V. 
Published: March 2024

This study provides a comprehensive account of 40 species (52 valid names and one preoccupied name) of the genus Nemophora Hoffmannsegg, 1798 described or recorded from Myanmar, Thailand, Laos, Cambodia and Vietnam. A key to the species based on external characters and on male genitalia is provided; 14 new species are described: N. auricapitella Kozlov, sp. nov., N. chalcoptera Kozlov, sp. nov., N. karsholti Kozlov, sp. nov., N. kuznetzovi Kozlov, sp. nov., N. meyi Kozlov, sp. nov., N. nielseni Kozlov, sp. nov., N. nieukerkeni Kozlov, sp. nov., N. nigripunctella Kozlov, sp. nov., N. punctifasciella Kozlov, sp. nov., N. rubicunda Kozlov, sp. nov., N. szabokyi Kozlov, sp. nov., N. thailandensis Kozlov, sp. nov., N. vietnamensis Kozlov, sp. nov. and N. yeni Kozlov, sp. nov. Lectotypes are designated for four species, including one junior synonym: Nemotois diplophragma Meyrick, 1938, Nemotois sinicella Walker, 1863, Nemotois cleodoxa Meyrick, 1922 and Adela satrapodes Meyrick, 1894. Eight new synonyms for four species are proposed: Nemophora badagongshana Liao, Hirowatari & Huang in Liao, Hirowatari, Yagi, Wang, Wang & Huang, 2023, syn. nov. of Nemophora aurifera (Butler, 1881); Nemotois chrysocharis Caradja, 1938, syn. nov. of Nemophora sinicella (Walker, 1863); Nemotois diplophragma Meyrick, 1938, syn. nov. of Nemophora melichlorias (Meyrick, 1907); Nemophora basalistriata Liao, Hirowatari & Huang in Liao, Hirowatari, Yagi, Wang, Wang & Huang, 2023, syn. nov. of Nemophora melichlorias (Meyrick, 1907); Nemotois limenites Meyrick, 1914, syn. nov. of Nemophora aurifera (Butler, 1881); Nemophora quadrata Liao, Hirowatari & Huang in Liao, Hirowatari, Yagi, Wang, Wang & Huang, 2023, syn. nov. of Nemophora aurifera (Butler, 1881); Nemotois rubrofascia formosicola Matsumura, 1931, syn. nov. of Nemophora sakaii (Matsumura, 1931); Nemotois servata Meyrick in Caradja, 1925, syn. nov. of Nemophora aurifera (Butler, 1881). Four new combinations are introduced: Nemophora aglaospila (Meyrick, 1928), comb. nov.; Nemophora cleodoxa (Meyrick, 1922), comb. nov.; Nemophora melichlorias (Meyrick, 1907), comb. nov.; and Nemophora sinicella (Walker, 1863), comb. nov. Of 40 species considered, 16 were recorded in Myanmar, 21 in Thailand, 4 in Laos, 4 in Cambodia and 13 in Vietnam.
Efficient Data-Driven Gap Filling of Satellite Image Time Series Using Deep Neural Networks with Partial Convolutions
Authors: Appel Marius 
Published: March 2024

Abstract
The abundance of gaps in satellite image time series often complicates the application of deep learning models such as convolutional neural networks for spatiotemporal modeling. Based on previous work in computer vision on image inpainting, this paper shows how three-dimensional spatiotemporal partial convolutions can be used as layers in neural networks to fill gaps in satellite image time series. To evaluate the approach, we apply a U-Net-like model on incomplete image time series of quasi-global carbon monoxide observations from the Sentinel-5 Precursor (Sentinel-5P) satellite. Prediction errors were comparable to two considered statistical approaches while computation times for predictions were up to three orders of magnitude faster, making the approach applicable to process large amounts of satellite data. Partial convolutions can be added as layers to other types of neural networks, making it relatively easy to integrate with existing deep learning models. However, the approach does not provide prediction uncertainties and further research is needed to understand and improve model transferability. The implementation of spatiotemporal partial convolutions and the U-Net-like model is available as open-source software.

Significance Statement
Gaps in satellite-based measurements of atmospheric variables can make the application of complex analysis methods such as deep learning approaches difficult. The purpose of this study is to present and evaluate a purely data-driven method to fill incomplete satellite image time series. The application on atmospheric carbon monoxide data suggests that the method can achieve prediction errors comparable to other approaches with much lower computation times. Results highlight that the method is promising for larger datasets but also that care must be taken to avoid extrapolation. Future studies may integrate the approach into more complex deep learning models for understanding spatiotemporal dynamics from incomplete data.
Meta-analysis of central and peripheral cannulation for type A aortic dissection
Authors: Naito Noritsugu , Takagi Hisato 
Published: March 2024

Background Acute type A aortic dissection necessitates rapid and effective arterial cannulation techniques for optimal outcomes. This meta-analysis compares the safety and effectiveness of direct aortic cannulation (AoC) with peripheral cannulation (PC) via the femoral or axillary arteries in aortic surgery for acute type A aortic dissection. Methods A systematic review following PRISMA guidelines identified 10 retrospective studies encompassing 2518 patients (961 AoC, 1557 PC). Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated to analyze perioperative characteristics, short-term mortality rates, and postoperative complications including stroke and acute kidney injury. Results Short-term mortality did not significantly differ between AoC and PC (OR [95% CI] = 0.78 [0.61-1.01], p = .06). Likewise, postoperative stroke (OR [95% CI] = 0.86 [0.63-1.17], p = .33) nor acute kidney injury (OR [95% CI] = 1.11 [0.89-1.37], p = .35) showed no significant differences. AoC exhibited shorter operation time whereas there were no significant differences in aortic cross clamp time and cardiopulmonary bypass time between both groups. Our meta-regression analysis, considering the distal extent of aortic replacement, indicated that variations in aortic replacement rates did not significantly impact the observed outcomes. Conclusion AoC is a viable alternative to PC for acute type A aortic dissection. While both approaches offer comparable outcomes, AoC’s advantage in shorter operation time warrants thoughtful consideration in clinical practice.
Medial Collateral Ligament Reconstruction With Autograft Versus Allograft: A Systematic Review
Authors: Blackwood Nigel O. , Blitz Jack A. , Vopat Bryan , Ierulli Victoria K. , Mulcahey Mary K. 
Published: March 2024

Background: Medial collateral ligament (MCL) reconstruction (MCLR) is performed after failed nonoperative treatment or high-grade MCL injury with associated valgus instability. Purpose: To evaluate clinical outcomes after MCLR with autograft versus allograft. Study Design: Systematic review, Level of evidence, 4. Methods: A systematic review was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The authors conducted a search of the PubMed, CINAHL, EMBASE, and Cochrane databases to identify studies comparing outcomes of MCLR with autograft versus allograft. Studies were included if they evaluated clinical outcomes after MCLR using autograft and/or allograft. Any study that included concomitant knee ligament injury other than the anterior cruciate ligament injury was excluded. A quality assessment was performed using the modified Coleman Methodology Score. Results: The initial search identified 746 studies, 17 of which met the inclusion criteria and were included in this review. The studies included 307 patients: 151 (49.2%) patients received autografts, and 156 (50.8%) received allografts. The most used autograft was the semitendinosus tendon (136 grafts; 90.1% of specified allografts), and the only allograft used was the Achilles tendon (110 grafts; 100% of specified autografts). The mean follow-up of the studies was 25.6 months. Postoperative pain (Lysholm scores) ranged from 82.9 to 94.8 in patients receiving autografts and 87.5 to 93 in patients receiving allografts. Postoperative range of motion was full in 8 of 15 (53.3%) patients receiving autografts compared with 82 of 93 (88.2%) patients receiving allografts. Five of the 151 (3.3%) patients who had MCLR with autografts had complications such as infection, instability, and prominent screws. Two of the 156 (1.3%) MCLRs with allografts developed complications of prominent screws and nonhealing incisions. Conclusion: MCLR with either autografts or allografts leads to improved patient-reported, radiographic, and clinical outcomes. Patient-reported postoperative pain was similar in patients receiving either graft type. Other outcomes were difficult to compare between graft types because of nonstandardized reporting and a lack of pre- and postoperative measurements. Therefore, there is no evidence of significantly improved outcomes in the use of either autograft or allograft with MCLR.