bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensitivity Enhancement in Photoconductive Light Field Sampling
Authors: Altwaijry Najd , Qasim Muhammad , Zimin Dmitry , Karpowicz Nicholas , Kling Matthias F. 
Published: March 2024

AbstractThe emerging field of lightwave electronics is driving optoelectronic information processing beyond current classical limitations and has the potential to eventually reach petahertz frequencies. One of the major obstacles in reaching not only higher switching frequencies but also higher repetition rates with low‐power light sources is the efficiency of related devices. A device is presented based on a multilayered material that shows a 13‐fold enhancement in terms of converting light to electric current compared to bulk solids. Furthermore, the device exhibits an almost flat intensity response within its working range. The outstanding properties of engineered multilayered devices promise to push technology for lightwave electronics applications.
Spectral Multiplexing of Rare‐Earth Emitters in a Co‐Doped Crystalline Membrane
Authors: Ulanowski Alexander , Früh Johannes , Salamon Fabian , Holzäpfel Adrian , Reiserer Andreas 
Published: March 2024

AbstractThe spectral addressing of many individual rare‐earth dopants in optical resonators offers great potential for realizing distributed quantum information processors. To this end, it is required to understand and control the spectral properties of the emitters in micron‐scale devices. Here, erbium emitters are investigated in a Fabry–Perot resonator that contains a 10 µm thin membrane of crystalline yttrium orthosilicate that is co‐doped with europium. The co‐doping allows for tailoring the inhomogeneous distribution of the emitter frequency. With this approach, more than 360 spectrally resolved emitters are observed with Purcell factors exceeding 35, each of which constitutes an individually addressable qubit within the micron‐scale resonator. In addition to this spectral multiplexing, the optical coherence is preserved up to 0.62(3) ms under dynamical decoupling. Without decoupling, the coherence still reaches the lifetime limit for the emitters with the strongest Purcell enhancement that leads up to a 110‐fold lifetime reduction, down to 0.104(9) ms. Future work may combine this with long‐lived nuclear spin memories, which makes the investigated co‐doped membranes a promising platform for quantum repeaters and distributed quantum computers.
Magnetically Reconfigurable Toroidal Metasurfaces
Authors: Acharyya Nityananda , Mallick Soumyajyoti , Rane Shreeya , Upadhyay Kahaly Mousumi , Roy Chowdhury Dibakar 
Published: March 2024

AbstractHarnessing electron spin within limited dimensions under applied magnetic fields can lead to spin‐assisted tunable light‐matter interactions, which form a crucial step in developing frequency‐agile opto‐spintronic structures toward next generation photonic devices. For this purpose, spin‐dependent magneto transport phenomena derived from ferromagnetic (FM)/nonmagnetic (NM) multilayer structures have recently emerged as a useful tool for dynamically tailoring electromagnetic waves. With this pretext, five layers of aluminum (Al)/nickel (Ni) based multilayer thin films in sub skin depth regime are studied in terahertz domain under low‐intensity (0 to 30 mT) magnetic fields while systematically varying the NM spacer layer (sandwiched between the FM layers) from 8 to 18 nm. Such thin multi‐layer films demonstrate conductivity variations up to ≈40% for 30 mT of applied field. Utilizing the same multilayer configurations, magnetic field induced tunability in a metasurface design is investigated that simultaneously manifests toroidal, dipolar, and other higher‐order modes. Further, multipolar analysis reveals that the nonradiative toroidal and radiative dipole modes can be enhanced by almost 56% and 183%, respectively, under 0–30 mT magnetic fields. Such magnetic field‐induced simultaneous control over radiative and non‐radiative resonances can be pivotal for next generation terahertz magnetophotonic devices.
Enantioselective Synthesis of Five to Eight‐Membered P‐Stereogenic Benzo‐Fused Heterocycles via Copper‐Catalyzed Dynamic Kinetic Resolution
Authors: Wang Xue , Liu Baixue , Ge Lei , Hou Shanbo , Liu Min , Yang Wenqiang 
Published: March 2024

AbstractP‐stereogenic benzo‐fused heterocycles is a privileged skeleton due to their outstanding catalytic properties and bioactivities. However, their enantioselective synthesis is still underdeveloped. Here we demonstrate the use of easily accessible racemic H−P(O) compounds as starting materials and commercial chiral N1, N2‐dimethyl‐1,2‐diphenylethane‐1,2‐diamine ligand in combination with Cu(I) catalysts to enable an attractive dynamic kinetic C(sp2)−P cross‐coupling reaction. This protocol not only exhibits a broad substrate scope but also provides general access to a diverse range of useful P‐stereogenic five‐, six‐, seven‐ and eight‐membered benzo‐fused O, P‐ containing heterocycles with good to high yields and enantioselectivities.
pH‐Activatable Pre‐Nanozyme Mediated H2S Delivery for Endo‐Exogenous Regulation of Oxidative Stress in Acute Kidney Injury
Authors: Jiang Wei , Hou Xinyue , Qi Yuanbo , Wang Zhigang , Liu Ying , Gao Xuejiao J. , Wu Tingting , Guo Jiancheng , Fan Kelong , Shang Wenjun 
Published: March 2024

AbstractOxidative stress induced by excess reactive oxygen species (ROS) is a primary pathogenic cause of acute kidney injury (AKI). Development of an effective antioxidation system to mitigate oxidative stress for alleviating AKI remains to be investigated. This study presents the synthesis of an ultra‐small Platinum (Pt) sulfur cluster (Pt5.65S), which functions as a pH‐activatable prefabricated nanozyme (pre‐nanozyme). This pre‐nanozyme releases hydrogen sulfide (H2S) and transforms into a nanozyme (Ptzyme) that mimics various antioxidant enzymes, including superoxide dismutase and catalase, within the inflammatory microenvironment. Notably, the Pt5.65S pre‐nanozyme exhibits an endo‐exogenous synergy‐enhanced antioxidant therapeutic mechanism. The Ptzyme reduces oxidative damage and inflammation, while the released H2S gas promotes proneurogenesis by activating Nrf2 and upregulating the expression of antioxidant molecules and enzymes. Consequently, the Pt5.65S pre‐nanozyme shows cytoprotective effects against ROS/reactive nitrogen species (RNS)‐mediated damage at remarkably low doses, significantly improving treatment efficacy in mouse models of kidney ischemia‐reperfusion injury and cisplatin‐induced AKI. Based on these findings, the H2S‐generating pre‐nanozyme may represent a promising therapeutic strategy for mitigating inflammatory diseases such as AKI and others.
Intelligence Sparse Sensor Network for Automatic Early Evaluation of General Movements in Infants
Authors: Bao Benkun , Zhang Senhao , Li Honghua , Cui Weidong , Guo Kai , Zhang Yingying , Yang Kerong , Liu Shuai , Tong Yao , Zhu Jia , Lin Yuan , Xu Huanlan , Yang Hongbo , Cheng Xiankai , Cheng Huanyu 
Published: March 2024

AbstractGeneral movements (GMs) have been widely used for the early clinical evaluation of infant brain development, allowing immediate evaluation of potential development disorders and timely rehabilitation. The infants’ general movements can be captured digitally, but the lack of quantitative assessment and well‐trained clinical pediatricians presents an obstacle for many years to achieve wider deployment, especially in low‐resource settings. There is a high potential to explore wearable sensors for movement analysis due to outstanding privacy, low cost, and easy‐to‐use features. This work presents a sparse sensor network with soft wireless IMU devices (SWDs) for automatic early evaluation of general movements in infants. The sparse network consisting of only five sensor nodes (SWDs) with robust mechanical properties and excellent biocompatibility continuously and stably captures full‐body motion data. The proof‐of‐the‐concept clinical testing with 23 infants showcases outstanding performance in recognizing neonatal activities, confirming the reliability of the system. Taken together with a tiny machine learning algorithm, the system can automatically identify risky infants based on the GMs, with an accuracy of up to 100% (99.9%). The wearable sparse sensor network with an artificial intelligence‐based algorithm facilitates intelligent evaluation of infant brain development and early diagnosis of development disorders.
Magnetic‐Assisted Control of Eggs and Embryos via Zona Pellucida‐Linked Nanoparticles
Authors: García‐Vázquez Francisco Alberto , Garrappa Gabriela , Luongo Chiara , Hamze Julieta Gabriela , Caballero María , Marco‐Jiménez Francisco , Vicente Antón José Salvador , Molina‐Cuberos Gregorio J. , Jiménez‐Movilla María 
Published: March 2024

AbstractEggs and embryo manipulation is an important biotechnological challenge to enable positioning, entrapment, and selection of reproductive cells to advance into a new era of nature‐like assisted reproductive technologies. Oviductin (OVGP1) is an abundant protein in the oviduct that binds reversibly to the zona pellucida, an extracellular matrix that surrounds eggs and embryos. Here, the study reports a new method coupling OVGP1 to magnetic nanoparticles (NP) forming a complex (NPOv). NPOv specifically surrounds eggs and embryos in a reversible manner. Eggs/embryos bound to NPOv can be moved or retained when subjected to a magnetic force, and interestingly only mature‐competent eggs are attracted. This procedure is compatible with normal development following gametes function, in vitro fertilization, embryo development and resulting in the birth of healthy offspring. The results provide in vitro proof‐of‐concept that eggs and embryos can be precisely guided in the absence of physical contact by the use of magnets.
A Multifunctional Metal–Phenolic Nanocoating on Bone Implants for Enhanced Osseointegration via Early Immunomodulation
Authors: Liu Jin , Shi Yilin , Zhao Yajun , Liu Yue , Yang Xiaoru , Li Kai , Zhao Weiwei , Han Jianmin , Li Jianhua , Ge Shaohua 
Published: March 2024

AbstractSurface modification is an important approach to improve osseointegration of the endosseous implants, however it is still desirable to develop a facile yet efficient coating strategy. Herein, a metal–phenolic network (MPN) is proposed as a multifunctional nanocoating on titanium (Ti) implants for enhanced osseointegration through early immunomodulation. With tannic acid (TA) and Sr2+ self‐assembled on Ti substrates, the MPN coatings provided a bioactive interface, which can facilitate the initial adhesion and recruitment of bone marrow mesenchymal stem cells (BMSCs) and polarize macrophage toward M2 phenotype. Furthermore, the TA‐Sr coatings accelerated the osteogenic differentiation of BMSCs. In vivo evaluations further confirmed the enhanced osseointegration of TA‐Sr modified implants via generating a favorable osteoimmune microenvironment. In general, these results suggest that TA‐Sr MPN nanocoating is a promising strategy for achieving better and faster osseointegration of bone implants, which can be easily utilized in future clinical applications.
ACE mRNA (Additional Chimeric Element incorporated IVT mRNA) for Enhancing Protein Expression by Modulating Immunogenicity
Authors: Son Sora , Park Minsa , Kim Jin , Lee Kyuri 
Published: March 2024

AbstractThe development of in vitro transcribed mRNA (IVT mRNA)‐based therapeutics/vaccines depends on the management of IVT mRNA immunogenicity. IVT mRNA, which is used for intracellular protein translation, often triggers unwanted immune responses, interfering with protein expression and leading to reduced therapeutic efficacy. Currently, the predominant approach for mitigating immune responses involves the incorporation of costly chemically modified nucleotides like pseudouridine (Ψ) or N1‐methylpseudouridine (m1Ψ) into IVT mRNA, raising concerns about expense and the potential misincorporation of amino acids into chemically modified codon sequences. Here, an Additional Chimeric Element incorporated mRNA (ACE mRNA), a novel approach incorporating two segments within a single IVT mRNA structure, is introduced. The first segment retains conventional IVT mRNA components prepared with unmodified nucleotides, while the second, comprised of RNA/DNA chimeric elements, aims to modulate immunogenicity. Notably, ACE mRNA demonstrates a noteworthy reduction in immunogenicity of unmodified IVT mRNA, concurrently demonstrating enhanced protein expression efficiency. The reduced immune responses are based on the ability of RNA/DNA chimeric elements to restrict retinoic acid‐inducible gene I (RIG‐I) and stimulator of interferon genes (STING)‐mediated immune activation. The developed ACE mRNA shows great potential in modulating the immunogenicity of IVT mRNA without the need for chemically modified nucleotides, thereby advancing the safety and efficacy of mRNA‐based therapeutics/vaccines.
Structural Relationships to Efficacy for Prazole‐Derived Antivirals
Authors: Nyenhuis David A. , Watanabe Susan , Bernstein Rebecca , Swenson Rolf E. , Raju Natarajan , Sabbasani Venkata R. , Mushti Chandrasekhar , Lee Duck‐Yeon , Carter Carol , Tjandra Nico 
Published: March 2024

AbstractHere, an in vitro characterization of a family of prazole derivatives that covalently bind to the C73 site on Tsg101 and assay their ability to inhibit viral particle production is presented. Structurally, increased steric bulk on the 4‐pyridyl of the prazole expands the prazole site on the UEV domain toward the β‐hairpin in the Ub‐binding site and is coupled to increased inhibition of virus‐like particle production in HIV‐1. Increased bulk also increased toxicity, which is alleviated by increasing flexibility. Further, the formation of a novel secondary Tsg101 adduct for several of the tested compounds and the commercial drug lansoprazole. The secondary adduct involved the loss of the 4‐pyridyl substituent to form an irreversible species, with implications for increasing the half‐life of the active species or its specificity toward Tsg101 UEV. It is also determined that sulfide derivatives display effective viral inhibition, presumably through cellular sulfoxidation, allowing for delayed conversion within the cellular environment, and identify SARS‐COV‐2 as a target of prazole inhibition. These results open multiple avenues for the design of prazole derivatives for antiviral applications.
Interplay Between Intracellular Transport Dynamics and Liquid‒Liquid Phase Separation
Authors: Zhang Ming‐Li , Zhang Ziheng , Niu Xue‐Zhi , Ti Hui‐Ying , Zhou Yu‐Xuan , Gao Bo , Li Yiwei , Liu Ji‐Long , Chen Xiaosong , Li Hui 
Published: March 2024

AbstractLiquid‒liquid phase separation (LLPS) is a ubiquitous process in which proteins, RNA, and biomolecules assemble into membrane‐less compartments, playing important roles in many biological functions and diseases. The current knowledge on the biophysical and biochemical principles of LLPS is largely from in vitro studies; however, the physiological environment in living cells is complex and not at equilibrium. The characteristics of intracellular dynamics and their roles in physiological LLPS remain to be resolved. Here, by using single‐particle tracking of quantum dots and dynamic monitoring of the formation of stress granules (SGs) in single cells, the spatiotemporal dynamics of intracellular transport in cells undergoing LLPS are quantified. It is shown that intracellular diffusion and active transport are both reduced. Furthermore, the formation of SG droplets contributes to increased spatial heterogeneity within the cell. More importantly, the study demonstrated that the LLPS of SGs can be regulated by intracellular dynamics in two stages: the reduced intracellular diffusion promotes SG assembly and the microtubule‐associated transport facilitates SG coalescences. The work on intracellular dynamics not only improves the understanding of the mechanism of physiology phase separations occurring in nonequilibrium environments but also reveals an interplay between intracellular dynamics and LLPS.
Direct‐Contact Seebeck‐Driven Transverse Magneto‐Thermoelectric Generation in Magnetic/Thermoelectric Bilayers
Authors: Zhou Weinan , Sasaki Taisuke , Uchida Ken‐ichi , Sakuraba Yuya 
Published: March 2024

AbstractTransverse thermoelectric generation converts temperature gradient in one direction into an electric field perpendicular to that direction and is expected to be a promising alternative in creating simple‐structured thermoelectric modules that can avoid the challenging problems facing traditional Seebeck‐effect‐based modules. Recently, large transverse thermopower has been observed in closed circuits consisting of magnetic and thermoelectric materials, called the Seebeck‐driven transverse magneto‐thermoelectric generation (STTG). However, the closed‐circuit structure complicates its broad applications. Here, STTG is realized in the simplest way to combine magnetic and thermoelectric materials, namely, by stacking a magnetic layer and a thermoelectric layer together to form a bilayer. The transverse thermopower is predicted to vary with changing layer thicknesses and peaks at a much larger value under an optimal thickness ratio. This behavior is verified in the experiment, through a series of samples prepared by depositing Fe–Ga alloy thin films of various thicknesses onto n‐type Si substrates. The measured transverse thermopower reaches 15.2 ± 0.4 µV K−1, which is a fivefold increase from that of Fe–Ga alloy and much larger than the current room temperature record observed in Weyl semimetal Co2MnGa. The findings highlight the potential of combining magnetic and thermoelectric materials for transverse thermoelectric applications.
Electrophilicity Modulation for Sub‐ppm Visualization and Discrimination of EDA
Authors: Zhao Hao , Liu Yuan , Li Gaosheng , Lei Da , Du Yuwan , Li Yudong , Tang Hui , Dou Xincun 
Published: March 2024

AbstractPrecise and timely recognition of hazardous chemical substances is of great significance for safeguarding human health, ecological environment, public security, etc., especially crucial for adopting appropriate disposition measures. Up to now, there remains a practical challenge to sensitively detect and differentiate organic amines with similar chemical structures with intuitive analysis outcomes. Here, a unique optical probe with two electrophilic recognition sites for rapid and ultra‐sensitive ratiometric fluorescence detection of ethylenediamine (EDA) is presented, while producing distinct fluorescence signals to its structural analog. The probe exhibits ppb/nmol level sensitivity to liquidous and gaseous EDA, specific recognition toward EDA without disturbance to up to 28 potential interferents, as well as rapid fluorescence response within 0.2 s. By further combining the portable sensing chip with the convolutional algorithm endowed with image processing, this work cracked the problem of precisely discriminating the target and non‐targets at extremely low concentrations.
Spacing of subsurface poultry litter bands: Influence on maize performance and nitrogen use efficiency
Authors: Simmons Jason R. , Ritchey Edwin L. , Sistani Karamat R. , Way Thomas R. , Coyne Mark S. , Matocha Christopher J. 
Published: March 2024

AbstractPoultry litter (PL) is traditionally surface broadcast to no‐till maize (Zea mays L.). PL is nutrient‐dense, and surface‐applied PL nitrogen (N) is vulnerable to losses to the atmosphere and water systems. An application method was developed by USDA‐ARS scientists for shallow subsurface banding PL to reduce ammonia (NH3) volatilization and surface runoff. There is limited information on how this application method will affect conservation and nutrient accessibility in no‐till maize. The objectives were to determine if adjusting PL lateral subsurface band placement in relation to maize rows affects nutrient use and maize yields. Treatments were a nontreated control (NTC), urea ammonium nitrate surface banded (Fert), poultry litter surface broadcast (PLBr), and three subsurface banded PL treatments. The subsurface PL treatments were one (PLSub1), two (PLSub2), or three (PLSub3) bands between maize rows. Treatments receiving N were applied at 180 kg total N ha−1. Nitrogen concentration in V4 aboveground dry matter was higher in PLSub1 than PLSub2. Aboveground dry matter yields for all PLSub treatments were greater than PLBr and comparable to Fert. The PLSub1 and PLSub2 treatments resulted in maize grain yields equivalent to Fert and greater than PLBr and NTC when averaged across years. Few differences were observed in postharvest soil sample nutrient concentrations between PLSub treatments. These results suggest that subsurface banding PL can conserve N and increase no‐till maize yield over traditional surface broadcast PL; however, increasing the frequency of subsurface PL bands did not clearly affect nutrient conservation or accessibility to the maize.
Helical Nanographenes Bearing Pentagon‐Heptagon Pairs by Stepwise Dehydrocyclization
Authors: Ju Yang‐Yang , Luo Huan , Li Ze‐Jia , Zheng Bing‐Hui , Xing Jiang‐Feng , Chen Xuan‐Wen , Huang Ling‐Xi , Nie Guo‐Hui , Zhang Bin , Liu Junzhi , Tan Yuan‐Zhi 
Published: March 2024

AbstractThe incorporation of pentagon‐heptagon pairs into helical nanographenes lacks a facile synthetic route, and the impact of these pairs on chiroptical properties remains unclear. In this study, a method for the stepwise construction of pentagon‐heptagon pairs in helical nanographenes by the dehydrogenation of [6]helicene units was developed. Three helical nanographenes containing pentagon‐heptagon pairs were synthesized and characterized using this approach. A wide variation in the molecular geometries and photophysical properties of these helical nanographenes was observed, with changes in the helical length of these structures and the introduction of the pentagon‐heptagon pairs. The embedded pentagon‐heptagon pairs reduced the oxidation potential of the synthesized helical nanographenes. The high isomerization energy barriers enabled the chiral resolution of the helicene enantiomers. Chiroptical investigations revealed remarkably enhanced circularly polarized luminescence and luminescence dissymmetry factors with an increasing number of the pentagon‐heptagon pairs.
Tailoring Second Coordination Sphere for Tunable Solid–Liquid Interfacial Charge Transfer toward Enhanced Photoelectrochemical H2 Production
Authors: Hu Yangguang , Zhou Wu , Gong Wanbing , Gao Chao , Shen Shaohua , Kong Tingting , Xiong Yujie 
Published: March 2024

AbstractThe recombination of photogenerated charge carriers severely limits the performance of photoelectrochemical (PEC) H2 production. Here, we demonstrate that this limitation can be overcome by optimizing the charge transfer dynamics at the solid–liquid interface via molecular catalyst design. Specifically, the surface of a p‐Si photocathode is modulated using molecular catalysts with different metal atoms and organic ligands to improve H2 production performance. Co(pda‐SO3H)2 is identified as an efficient and durable catalyst for H2 production through the rational design of metal centers and first/second coordination spheres. The modulation with Co(pda‐SO3H)2, which contains an electron‐withdrawing −SO3H group in the second coordination sphere, elevates the flat‐band potential of the polished p‐Si photocathode and nanoporous p‐Si photocathode by 81 mV and 124 mV, respectively, leading to the maximized energy band bending and the minimized interfacial carrier transport resistance. Consequently, both the two photocathodes achieve the Faradaic efficiency of more than 95 % for H2 production, which is well maintained during 18 h and 21 h reaction, respectively. This work highlights that the band‐edge engineering by molecular catalysts could be an important design consideration for semiconductor–catalyst hybrids toward PEC H2 production.