bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sociodemographic, nutritional and anthropometric factors determining overweight and obesity in an adult moroccan population
Authors: Barakat Imane , Elfane Houda , El-Jamal Sanaa , Elayachi Mohammed , Belahsen Rekia 
Published: March 2024

BACKGROUND: Knowledge of the determinants of the weight status of a population is important to be considered in actions aimed at improving public health. OBJECTIVE: The aim was to study the sociodemographic, nutritional and anthropometric factors associated with overweight and obesity in an adult Moroccan population. METHODS: This study focused on 507 adult subjects from the Rabat-Salé-Kénitra region in Morocco, according to a validated conceptual and methodological framework. Sociodemographic data were collected using a questionnaire, physical activity (PA) was assessed by the Marshal questionnaire, dietary intakes were estimated by a “dietary history” type survey. Anthropometric parameters were also measured using impedancemetry and a tape measure. RESULTS: The majority of the study population was 20 to 29 years old, females, urban and had an medium socio-economic level (SEL). The population’s dietary intake was high in calories, proteins, carbohydrates, fats, sugars, and sodium; and low in vitamin C, vitamin A, vitamin E, folic acid, iron, calcium and zinc. Univariate analysis revealed that overweight and obesity are associated with the 30–39 yrs age group, average SEL, insufficient PA, high intakes of calories, proteins, carbohydrates and lipids, as well as with high waist circumference and excessive body fat percentage. CONCLUSION: Factors associated with overweight and obesity were identified in the study population, revealing a coexistence of high intakes of energy and macronutrient and low intake of several micronutrients. The prevalence of deficiencies and excesses of these intakes testifys of a double burden of malnutrition in this population. The results are very relevant for guiding nutritional education actions among this population.
Synthesis and biological potential of S-derivatives of 7'-((3-mercapto-4-methyl-1,2,4-triazol-5-yl)-methyl)-3-methylxanthine
Authors: Гоцуля А. С. , Трофімова Т. С. 
Published: March 2024

One of the most modern strategies for the development of biologically active compounds is the active use of «privileged structures» with a certain range of known beneficial properties. The combination of fragments of such structures within one molecule with their subsequent targeted functionalization increases the probability of effective and selective interaction with certain biological targets. Therefore, the choice of 3-methylxanthine and 1,2,4-triazole for the practical implementation of this concept has a scientific basis and seems promising.
The aim of this work has been to synthesize and evaluate the biological potential of new derivatives of 7'-((3-mercapto-4-methyl-1,2,4-triazol-5-yl)methyl)-3-methylxanthine.
The starting 3-methylxanthine has been converted to 7'-((3-mercapto-4-methyl-1,2,4-triazol-5-yl)methyl)-3-methylxanthine by stepwise functionalization and heterocyclization. The obtained product with a thiol group has been involved in S-alkylation with halogenated carboxylic acids and their derivatives (amide, nitriles), as well as halogen ketones. The structure and individuality of the synthesized compounds have been confirmed by elemental analysis, IR and 1H NMR spectroscopy and chromatography-mass spectrometry. The compliance of the pharmacokinetic parameters and physical properties of the obtained substances with the drug-like criteria has been assessed using the SwissADME online platform.
Under the established optimal conditions of synthesis, 9 carbonyl derivatives of 7'-((3-mercapto-4-methyl-1,2,4-triazol-5-yl)methyl)-3-methylxanthine, including carboxylic acids, nitriles, ketones and amides, have been successfully obtained. A predictive assessment of the pharmacokinetic parameters of the drug-like compounds has been carried out, which supports the feasibility of further research to create a promising biologically active substance.
Kandungan fitokimia dan aktivitas antibakteri madu Heterotrigona itama yang diternakkan pada areal tumbuhan caliandra (Calliandra culothyrsus) terhadap bakteri Escherichia coli
Authors: Arung Enos Tangke , Ardy Ari , Syafrizal Syafrizal , Naibaho Netty , Paramita Swandari 
Published: March 2024

Madu Heterotrigona itama dikenal sebagai alternatif dalam pengobatan yang sering dijumpai dengan langsung dikonsumsi. Kemampuan madu dalam menghambat aktivitas bakteri karena mengandung senyawa antiseptik. Penelitian ini bertujuan untuk mengeksplorasi potensi madu lebah tanpa sengat (kelulut) Heterotrigona itama yang diternakkan pada areal tumbuhan kaliandra dalam menghambat aktivitas bakteri Escherichia coli selama 6 bulan pengamatan (Oktober 2022 – Maret 2023). Penelitian ini menggunakan metode difusi agar untuk menguji sifat antibakteri madu. Prosedur ini meliputi penuangan media nutrient agar ke cawan petri dan dibiarkan mengering. Kemudian, dibuat lubang pada media dan ditambahkan suspensi bakteri. Dilakukan pengujian pada sampel secara intensif selama enam bulan. Kloramfenikol digunakan sebagai kontrol positif dan aquades sebagai kontrol negatif. Hasil menunjukkan bahwa madu lebah tanpa sengat Heterotrigona itama efektif dalam menghambat pertumbuhan bakteri Escherichia coli. Sifat antibakteri madu dipengaruhi oleh efek senyawa bioaktif yang dominan.
REGULATORY AND LEGAL CHALLENGES OF SHARIA PEER-TO-PEER LENDING IN INDONESIA
Authors: Yulitasari Lis , Suryanto Tulus , Hilal Syamsul 
Published: March 2024

Peer-to-peer (P2P) lending is a financial platform that connects lenders directly with borrowers without going through traditional financial intermediaries. Sharia P2P lending applies sharia principles in its transactions. Even though sharia P2P lending in Indonesia has increased in recent years, regulatory and legal challenges still hamper its growth. This research aims to analyze the regulatory and legal challenges faced by Sharia P2P lending in Indonesia and provide policy recommendations to overcome them. This research uses qualitative methods by conducting a literature review of sharia P2P lending regulations in Indonesia and in-depth interviews with regulators, sharia P2P lending practitioners, and academics. The research results show that the main challenges faced are regulatory uncertainty, the need for a Sharia legal framework for P2P lending, and the regulator's lack of understanding of the Sharia-based P2P lending business model. The proposed policy recommendations include establishing a comprehensive and integrated Sharia P2P lending regulatory framework, preparing legally binding Sharia fatwas, and increasing regulators' literacy and understanding of the digital Sharia financial sector. The policy implications of this research can provide input for regulators and practitioners in developing a healthy and sustainable Sharia P2P lending ecosystem in Indonesia.
The comparison of islamic and conventional banking in ownership structure and interest rates in Indonesia
Authors: Hartini Titin , Lidyah Rika , Safitri Nurfala 
Published: March 2024

Ownership structure and interest rates are important factors affecting a bank's performance. Previous studies have found the effect of ownership structure and interest rates on company performance, but no one has specifically examined differences in Banking performance in ownership structure and interest rates. This study aims to compare the performance of Islamic and conventional banking in ownership structure and interest rates. In study, the author used quantitative methods that emphasize the analysis of numerical data processed using Stata 16. Based on the unstructured data panel, there are 13 Islamic banking and 107 conventional banking, the total banks used as objects are 120 banks with 1110 observations. The results are local ownership did not affect the performance of Islamic banks, compared to conventional banking on the contrary. Foreign ownership in Islamic banking affects Banking performance, while conventional banking has no effect. Furthermore, government ownership affects the performance of Islamic banks, but does not affect the performance of conventional banking. Based on the results of the study, it can be proven that government and foreign interference in the ownership of Islamic banking plays a role in improving the bank's performance. Whereas conventional banking has performed well under local ownership.
Identifikasi Pasien Sepsis Rumah Sakit Ibnu Sina Makassar
Authors: Qarinah Maryam , Mangarengi Yusriani , Mulyadi Farah Ekawati , Wiriansya Edward Pandu , Abdi Dian Amelia 
Published: March 2024

Sepsis menjadi salah satu penyebab morbiditas, mortalitas dan pengeluaran biaya kesehatan yang cukup besar di seluruh dunia. Beberapa faktor yang berpengaruh dalam tingginya angka kematian pada kasus sepsis di identifikasi dari beberapa daftar pustaka yaitu usia lanjut, wanita hamil, bayi, pasien rawat inap di rumah sakit, dan kondisi yang mempengaruhi imunitas dan kesehatan. Penelitian ini bertujuan mengidentifikasi pasien sepsis di Rumah Sakit Ibnu Sina Makassar berdasarkan usia, jenis kelamin, jenis infeksi dan diagnosis awal. Penelitian ini merupakan penelitian deskriptif observasional data sekunder rekam medis penderita sepsis di Rumah Sakit Ibnu Sina Makassar pada periode Oktober 2018-Desember 2020. Penelitian ini menemukan 40 sampel kasus sepsis. Kejadian sepsis banyak terjadi pada kelompok usia 58-67 tahun yaitu sebanyak 12 orang (30%), 8 orang pada usia 48-57 tahun, 7 orang (17.5%) pada kelompok usia 38-47 tahun, 6 orang (15%) pada kelompok usia 68- 77 tahun, 3 orang(7.5%) pada usia 18-27 tahun, 2 orang (5%) pada usia 28-37 tahun dan masing-masing 1 orang (2.5%) pada kelompok usia 78-87 dan 88-97 tahun. Sebanyak 21 orang (52.5%) pasien sepsis adalah perempuan. Jenis Infeksi yang terjadi adalah 80% oleh bakteri dan 20% oleh virus. Diagnosis awal tertinggi yaitu berasal dari pneumonia.
Anxiety Analysis of Petanque Athletes from West Java
Authors: Iskandar Tatang 
Published: March 2024

The purpose of this study was to analyze the levels of anxiety of West Java pétanque athletes before, during, and after the Provincial Sports Week (PORPROV) XIV match in Ciamis Regency. This study used a quantitative descriptive research design. The population in this study were 146 Petanque athletes who participated in the West Java PORPROV XIV Year 2022 in Ciamis regency. This study used a purposive sample technique with the criteria of medal winners at the West Java PORPROV in 2022. The number of samples obtained was 78 athletes. Theis study used a closed questionnaire as a research instrument. The results of this study show that female athletes of West Java have a relatively high level of anxiety while male athletes have a relatively medium level of anxiety. In general, the participants have medium level of anxiety before and after the match. On the other hand, the participants were shown to have a high level of anxiety during the match.
PENDAMPINGAN MUJAHADAH DAN ISTIGHOSAH UNTUK MENINGKATKAN KECERDASAN SPIRITUAL KEAGAMAAN SANTRI DAN MASYARAKAT
Authors: Choiri Moh Miftahul , Nurdiansyah Denny , Rokhim Auliyaur 
Published: March 2024

Abstract : This Mujahadah and Istighosah activity was carried out in order to guard and develop the spirituality of the community and students in the Raudhatul Ulum Campurejo Bojonegoro Islamic Boarding School. A person's spiritual level sometimes rises, sometimes falls, so efforts are needed to stabilize this condition. For example, there is a student who has just entered the boarding school and is naughty at first, then after being at the boarding school and graduating, he becomes an obedient child. This cannot be separated from the efforts of a kyai or ustadz, namely dhohir and inner efforts. Dhohir's efforts include teaching, directing, educating and so on. Meanwhile, inner efforts are prayer, penance, mujahadah, istighosah and so on. These two efforts must be carried out in balance. So we, as a community service team, want to hold Mujahadah and Istighosah assistance activities to improve the religious spirituality of the community and students in the Raudhatul Ulum Campurejo Islamic Boarding School, Bojonegoro. The Community Service method used is the Participatory Action Research model. Namely, the mentor goes directly to the field to oversee the mentoring process from the beginning to the end of the activity. The stages or steps that will be taken in carrying out mujahadah and Istighosah assistance to increase religious spiritual intelligence are as follows: Identification of needs and goals, Determining companions, Gathering information, Forming groups or clusters, Preparing programs and schedules, Implementing mujahadah and istighosah practices, Teaching mujahadah and istighosah material, Monitoring and evaluation, Support and motivation and finally program evaluation
Keywords: Mujahadah, Istighosah, Spiritual intelligence
Towards optimized tissue regeneration: a new 3D printable bioink of alginate/cellulose hydrogel loaded with thrombocyte concentrate
Authors: Grandjean Till , Perumal Natarajan , Manicam Caroline , Matthey Björn , Wu Tao , Thiem Daniel G. E. , Stein Stefan , Henrich Dirk , Kämmerer Peer W. , Al-Nawas Bilal , Ritz Ulrike , Blatt Sebastian 
Published: March 2024

Introduction:Autologous platelet concentrate (APC) are pro-angiogenic and can promote wound healing and tissue repair, also in combination with other biomaterials. However, challenging defect situations remain demanding. 3D bioprinting of an APC based bioink encapsulated in a hydrogel could overcome this limitation with enhanced physio-mechanical interface, growth factor retention/secretion and defect-personalized shape to ultimately enhance regeneration.Methods:This study used extrusion-based bioprinting to create a novel bioink of alginate/cellulose hydrogel loaded with thrombocyte concentrate. Chemico-physical testing exhibited an amorphous structure characterized by high shape fidelity. Cytotoxicity assay and incubation of human osteogenic sarcoma cells (SaOs2) exposed excellent biocompatibility. enzyme-linked immunosorbent assay analysis confirmed pro-angiogenic growth factor release of the printed constructs, and co-incubation with HUVECS displayed proper cell viability and proliferation. Chorioallantoic membrane (CAM) assay explored the pro-angiogenic potential of the prints in vivo. Detailed proteome and secretome analysis revealed a substantial amount and homologous presence of pro-angiogenic proteins in the 3D construct.Results:This study demonstrated a 3D bioprinting approach to fabricate a novel bioink of alginate/cellulose hydrogel loaded with thrombocyte concentrate with high shape fidelity, biocompatibility, and substantial pro-angiogenic properties.Conclusion:This approach may be suitable for challenging physiological and anatomical defect situations when translated into clinical use.
Metabarcoding clarifies the diet of the elusive and vulnerable Australian tjakura (Great Desert Skink, Liopholis kintorei)
Authors: Thuo David , Macgregor Nicholas A. , Merson Samuel D. , Scopel Dianne , Keogh J. Scott , Kenny Jeremy , Williams Jessica L. , Guest Tracey , Swan Shaeleigh , McAlpin Steve , Joseph Leo 
Published: March 2024

IntroductionAccurately quantifying the diet of species has implications for our understanding of their ecology and conservation. Yet, determining the dietary composition of threatened and elusive species in the wild is often difficult.MethodsThis study presents the first dietary assessment of tjakura (Liopholis kintorei) using non-invasive sampling of scats and high-throughput sequencing techniques.ResultsThe tjakura in Uluru consumed 48 invertebrates, 27 plants, and two vertebrate taxa. Fruit flies (Leucophenga spp.), beetles (Harpalus spp. and Omorgus spp.), mosquitos (Culicidae spp.), termites (Termitidae spp.), spiked mallow (Malvastrum americanum), bush tomatoes (Solanum centrale), and wild turnip (Brassica tournefortii) comprised the majority of the diet. Analysis of similarity revealed that food items did not differ significantly between tjakura age groups, seasons, or time since the last fire, however, adults, hot season, and fire scar of 2018 showed a relatively higher prey diversity.DiscussionThese high similarities in diet composition between age classes and fire scars indicate potential intraspecific competition when food resources are scarce. The diet diversity and potential plasticity observed in this study reflect a dietary ecology influenced by food availability rather than preference. Our study demonstrates that scat DNA metabarcoding is an important complementary tool to conventional scat analysis or indigenous knowledge as most food items we identified were previously not recorded through those methods.
Unveiling the role of tRNA-derived small RNAs in MAPK signaling pathway: implications for cancer and beyond
Authors: Wang Qurui , Huang Qinyuan , Ying Xiaowei , Shen Jinze , Duan Shiwei 
Published: March 2024

tRNA-derived small RNAs (tsRNAs) are novel small non-coding RNAs originating from mature or precursor tRNAs (pre-tRNA), typically spanning 14 to 30 nt. The Mitogen-activated protein kinases (MAPK) pathway orchestrates cellular responses, influencing proliferation, differentiation, apoptosis, and transformation. tsRNAs influence the expression of the MAPK signaling pathway by targeting specific proteins within the pathway. Presently, four MAPK-linked tsRNAs have implications in gastric cancer (GC) and high-grade serous ovarian cancer (HGSOC). Notably, tRF-Glu-TTC-027 and tRF-Val-CAC-016 modulate MAPK-related protein expression, encompassing p38, Myc, ERK, CyclinD1, CyclinB, and c-Myc, hindering GC progression via MAPK pathway inhibition. Moreover, tRF-24-V29K9UV3IU and tRF-03357 remain unexplored in specific mechanisms. KEGG analysis posits varied tsRNAs in MAPK pathway modulation for diverse non-cancer maladies. Notably, high tRF-36-F900BY4D84KRIME and tRF-23-87R8WP9IY expression relates to varicose vein (VV) risk. Elevated tiRNA-Gly-GCC-001, tRF-Gly-GCC-012, tRF-Gly-GCC-013, and tRF-Gly-GCC-016 target spinal cord injury (SCI)-related brain-derived neurotrophic factor (BDNF), influencing MAPK expression. tRF-Gly-CCC-039 associates with diabetes foot sustained healing, while tRF-5014a inhibits autophagy-linked ATG5 in diabetic cardiomyopathy (DCM). Additionally, tsRNA-14783 influences keloid formation by regulating M2 macrophage polarization. Upregulation of tRF-Arg-ACG-007 and downregulation of tRF-Ser-GCT-008 are associated with diabetes. tsRNA-04002 alleviates Intervertebral disk degeneration (IDD) by targeting PRKCA. tsRNA-21109 alleviates Systemic lupus erythematosus (SLE) by inhibiting macrophage M1 polarization. The upregulated tiNA-Gly-GCC-002 and the downregulated tRF-Ala-AGC-010, tRF-Gln-CTG-005 and tRF-Leu-AAG-001 may be involved in the pathogenesis of Lupus nephritis (LN) by affecting the expression of MAPK pathway. Downregulation of tsRNA-1018, tsRNA-3045b, tsRNA-5021a and tsRNA-1020 affected the expression of MAPK pathway, thereby improving Acute lung injury (ALI). This review comprehensively dissects tsRNA roles in MAPK signaling across cancers and other diseases, illuminating a novel avenue for translational medical exploration.
Indole-3-carbinol attenuates lipopolysaccharide-induced acute respiratory distress syndrome through activation of AhR: role of CCR2+ monocyte activation and recruitment in the regulation of CXCR2+ neutrophils in the lungs
Authors: Holloman Bryan Latrell , Wilson Kiesha , Cannon Alkeiver , Nagarkatti Mitzi , Nagarkatti Prakash S. 
Published: March 2024

IntroductionIndole-3-carbinol (I3C) is found in cruciferous vegetables and used as a dietary supplement. It is known to act as a ligand for aryl hydrocarbon receptor (AhR). In the current study, we investigated the role of AhR and the ability of I3C to attenuate LPS-induced Acute Respiratory Distress Syndrome (ARDS).MethodsTo that end, we induced ARDS in wild-type C57BL/6 mice, Ccr2gfp/gfp KI/KO mice (mice deficient in the CCR2 receptor), and LyZcreAhRfl/fl mice (mice deficient in the AhR on myeloid linage cells). Additionally, mice were treated with I3C (65 mg/kg) or vehicle to investigate its efficacy to treat ARDS.ResultsI3C decreased the neutrophils expressing CXCR2, a receptor associated with neutrophil recruitment in the lungs. In addition, LPS-exposed mice treated with I3C revealed downregulation of CCR2+ monocytes in the lungs and lowered CCL2 (MCP-1) protein levels in serum and bronchoalveolar lavage fluid. Loss of CCR2 on monocytes blocked the recruitment of CXCR2+ neutrophils and decreased the total number of immune cells in the lungs during ARDS. In addition, loss of the AhR on myeloid linage cells ablated I3C-mediated attenuation of CXCR2+ neutrophils and CCR2+ monocytes in the lungs from ARDS animals. Interestingly, scRNASeq showed that in macrophage/monocyte cell clusters of LPS-exposed mice, I3C reduced the expression of CXCL2 and CXCL3, which bind to CXCR2 and are involved in neutrophil recruitment to the disease site.DiscussionThese findings suggest that CCR2+ monocytes are involved in the migration and recruitment of CXCR2+ neutrophils during ARDS, and the AhR ligand, I3C, can suppress ARDS through the regulation of immune cell trafficking.
Computational identification and experimental verification of a novel signature based on SARS-CoV-2–related genes for predicting prognosis, immune microenvironment and therapeutic strategies in lung adenocarcinoma patients
Authors: Wang Yuzhi , Xu Yunfei , Deng Yuqin , Yang Liqiong , Wang Dengchao , Yang Zhizhen , Zhang Yi 
Published: March 2024

BackgroundEarly research indicates that cancer patients are more vulnerable to adverse outcomes and mortality when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nonetheless, the specific attributes of SARS-CoV-2 in lung Adenocarcinoma (LUAD) have not been extensively and methodically examined.MethodsWe acquired 322 SARS-CoV-2 infection-related genes (CRGs) from the Human Protein Atlas database. Using an integrative machine learning approach with 10 algorithms, we developed a SARS-CoV-2 score (Cov-2S) signature across The Cancer Genome Atlas and datasets GSE72094, GSE68465, and GSE31210. Comprehensive multi-omics analysis, including assessments of genetic mutations and copy number variations, was conducted to deepen our understanding of the prognosis signature. We also analyzed the response of different Cov-2S subgroups to immunotherapy and identified targeted drugs for these subgroups, advancing personalized medicine strategies. The expression of Cov-2S genes was confirmed through qRT-PCR, with GGH emerging as a critical gene for further functional studies to elucidate its role in LUAD.ResultsOut of 34 differentially expressed CRGs identified, 16 correlated with overall survival. We utilized 10 machine learning algorithms, creating 101 combinations, and selected the RFS as the optimal algorithm for constructing a Cov-2S based on the average C-index across four cohorts. This was achieved after integrating several essential clinicopathological features and 58 established signatures. We observed significant differences in biological functions and immune cell statuses within the tumor microenvironments of high and low Cov-2S groups. Notably, patients with a lower Cov-2S showed enhanced sensitivity to immunotherapy. We also identified five potential drugs targeting Cov-2S. In vitro experiments revealed a significant upregulation of GGH in LUAD, and its knockdown markedly inhibited tumor cell proliferation, migration, and invasion.ConclusionOur research has pioneered the development of a consensus Cov-2S signature by employing an innovative approach with 10 machine learning algorithms for LUAD. Cov-2S reliably forecasts the prognosis, mirrors the tumor’s local immune condition, and supports clinical decision-making in tumor therapies.