bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Excited When They See Their Name in Print”: Research Outputs from an Australian Medical Program
Authors: Dinh Harry Hieu , Uebel Kerry , Iqbal Maha Pervaz , Grant Ari , Shulruf Boaz , Nathan Sally , Vo Khanh , Smith Greg , Carland Jane Ellen 
Published: March 2024

AbstractTo promote evidence-based practice, medical schools offer students opportunities to undertake either elective or mandatory research projects. One important measure of the research program success is student publication rates. In 2006, UNSW Medicine implemented a mandatory research program in the 4th year of the undergraduate medical education program. This study identified student publication rates and explored student and supervisor experiences with the publication process.A retrospective audit of student publications from the 2007, 2011, and 2015 cohorts was undertaken to look at trends over time. Data collected included type of publication and study methodology. Semi-structured interviews were conducted with a sample of undergraduate students (n = 11), medical graduates (n = 14), and supervisors (n = 25) and analysed thematically.Student publication rates increased significantly (P = 0.002) from 28% in 2007 to 50.2% in 2015. Students able to negotiate their own project were more likely to publish (P = 0.02). Students reported personal affirmation and development of research skills from publishing their research findings, while graduates noted improved career opportunities. Supervisors expected students to publish but identified the time to publications and student motivation as key factors in achieving publication(s).A high publication rate is possible in a mandatory research program where students can negotiate their own topic and are given protected time. Publications happen after the research project has finished. Critical factors in successful publication include supervisor support and student motivation. Given the importance of the supervisor’s role, staff development and faculty support to train and develop a body of skilled supervisors is required.
Shared Space: promoting teachers’ academic understanding of inter-religious dialogue through a teacher fellowship model for religious education (RE)
Authors: Orchard Janet , Bowen Victoria 
Published: March 2024

AbstractWe report on the design of a close-to-practice research project situated in Southwest England exploring the relationship between developing teachers’ ‘powerful knowledge’ of inter-religious dialogue in religious education (RE) through a teacher fellowship model for RE specialists, including a specialist curriculum development programme and co-constructed evaluation of an intervention seeking to promote ‘warmer’ community relations. This current phase of the ‘Shared Space’ project combines insight from two existing subject-specific knowledge exchange projects—undertaken by us—with a Teacher Fellowship approach to pedagogical and curriculum knowledge development pioneered by the Historical Association, and an emerging one, ‘After RE’. The current Shared Space project addresses two established concerns in RE that are not normally connected: (1) the lack of rigorous subject knowledge held by RE teachers in England; (2) the assumption that good RE in schools can promote community relations, a widely accepted assumption hitherto without much evidence to support it. Here we set out a justification for the project and the form it will take, based on established Shared Space principles of how best to support in-service teachers’ ongoing professional development through knowledge exchange with academics, mindful of equal power relations. While appreciating aspects of the notion of ‘powerful knowledge’ on which ‘theory-rich’ Teacher Fellowships have been based, we cite thinking from the emerging After RE project to suggest a modified theoretical framework for our investigation which will innovate methodologically when evaluating its impact in partnership with teacher participants.
Thermal Penetration of Aircraft Tyre Tread at Touchdown
Authors: Li Yu , Wang Weiji 
Published: March 2024

AbstractMost studies of friction and heat conduction in aircraft tyres at touchdown are limited to the tread surface. However, it is necessary to know the thermal penetration inside the tread to study the quantity of the potential decomposed and lost material by the frictional heat. Additionally, a high tread surface temperature does not necessarily guarantee a stronger thermal penetration inside the tread because of several factors. Therefore, it is necessary to establish a relationship between the tyre tread surface temperature and the internal heat penetration under the aircraft touchdown scenario. A model is established on MATLAB to simulate the aircraft tyre dynamics and tread heat conduction at touchdown. This model is capable of calculating the temperature increase in the tread, both on the surface and inside. It can also be used to determine the depth of thermal decomposition caused by frictional heat. Additionally, the study found that the Thermal Decomposition Depth to Surface Temperature Ratios (DTRs) are similar across the tread (the depth of thermal decomposition at each part of the tread surface is proportional to the surface temperature). Therefore, it can estimate the thermal penetration throughout the tread by simply calculating the surface temperature of the entire tread and the average DTR at several points of interest. The study provides a more straightforward approach for aircraft tyre thermal wear prediction and future research.
Modified rice husk as component in recyclable and biodegradable epoxy thermosets
Authors: Yiga Vianney Andrew , Subramaniyan Sathiyaraj , Kalita Naba Kumar , Lubwama Michael , Hakkarainen Minna 
Published: March 2024

AbstractRice husk (RH), an abundant agricultural residue, was successfully chemically modified and used as a component in reprocessable and biodegradable epoxy thermosets. First, RH was subjected to alkaline treatment to increase the cellulose content followed by succinylation and curing with trimethylolpropane triglycidyl ether to form the thermoset films. The chemical structure of the different intermediates and thermosets was confirmed by Fourier transform infrared spectroscopy. The developed thermoset films had good solvent resistance against common organic solvents and good thermal stability as measured by thermogravimetry with peak temperatures of 347–387 ℃, char residues of 16–20% and limiting oxygen index values of 24–26%, respectively. The films could be thermally reprocessed by hot-pressing with excellent recovery of the mechanical properties (92–96% recovery of tensile stress). Furthermore, 80–84% biodegradation during 150 days under mesophilic home composting conditions was demonstrated by cumulative CO2 evolution. These results indicate promising potential for the developed RHs thermosets as replacements for petroleum-based plastics in e.g. packaging and agricultural applications.
End-of-life cohorts from the Dartmouth Institute: risk adjustment across health care markets, the relative efficiency of chronic illness utilization, and patient experiences near the end of life
Authors: Bronner Kristen K. , Goodman David C. 
Published: March 2024

AbstractSince their inception, small area studies intended to measure health system performance have been challenged by concerns that regional variation in health care may be primarily explained by differences in patient health risk. Controlling for regional population differences depends on appropriate risk adjustment, but the adequacy of the methods used in early analyses was contested. A novel response to these concerns was the development of end-of-life cohorts by Dartmouth Atlas investigators. These were used initially to control for differences in population health status in studies investigating relative efficiency across regions. Later, they became useful for studying hospital-level variation in chronic illness care, and for measuring utilization and patient experiences at the very end of life. Altogether, end-of-life cohorts have been invaluable for clarifying the contribution of health system and provider factors to health care variation and outcomes.
Heterogeneous and Composite Bioinks for 3D-Bioprinting of Complex Tissue
Authors: Rasouli Rahimeh , Sweeney Crystal , Frampton John P. 
Published: March 2024

Abstract
Bioink composition is a key consideration for the 3D-bioprinting of complex and stable structures used to model tissues and as tissue constructs for regenerative medicine. An emerging and industrially important area of research is the use of micro- and nanofillers to improve bioink performance without dramatically altering the physicochemical properties of the polymeric material that forms the bulk of the printed structure. The purpose of this review is to provide a comprehensive overview of emerging nanomaterial fillers designed to create heterogeneous and composite bioinks for 3D-bioprinting of complex functional tissues. We outline the criteria that must be considered when developing such a bioink and discuss applications where the fillers impart stimuli responsiveness, e.g., when exposed to magnetic fields, electrical fields, and light. We further highlight how the use of such fillers can enable non-destructive imaging to monitor scaffold placement and integrity following implantation.
A Cost Model for Ocean Iron Fertilization as a Means of Carbon Dioxide Removal That Compares Ship‐ and Aerial‐Based Delivery, and Estimates Verification Costs
Authors: Emerson David , Sofen Laura E. , Michaud Alexander B. , Archer Stephen D. , Twining Benjamin S. 
Published: March 2024

AbstractWe present a cost model for implementing a deployment scale effort for conducting ocean iron fertilization (OIF) for marine‐based carbon dioxide removal (CDR). The model incorporates basic oceanographic parameters critical for estimating the effective export of newly fixed CO2 into biomass that is stimulated by Fe addition to an Fe‐limited region of the Southern Ocean. Estimated costs can vary by nearly 100‐fold between best‐case and worst‐case scenarios, with best‐case values of $7/net tonne C captured versus worst‐case $1,500/net tonne C captured, without accounting for verification costs. Primary oceanographic factors that influence cost are the net primary productivity increases achieved via OIF, the amount of C exported into the deep ocean, and the amount of CO2 ventilated back to the atmosphere. The model compares ship‐based versus aerial delivery of Fe to the ocean, and estimates aerial delivery can be 30%–40% more cost effective; however, the specific requirements for aerial delivery require additional research and development. The model also estimates costs associated with verification and environmental monitoring of OIF. These costs increase $/net tonne C captured by 3–4‐fold. Best, intermediate, and worst cases for aerial delivery and ship delivery are $21, $83, $2,033, and $24, $94, $4,691, respectively, inclusive of verification costs. The primary goal of this model is to demonstrate the variability in cost of OIF as a CDR method, and to better understand where additional research is needed to determine the major factors that may make OIF a tractable, nature‐based CDR method.
Distribution of Seed Electron Phase Space Density Minima in Earth's Radiation Belts
Authors: Drozdov A. Y. , Allison H. J. , Saikin A. A. , Schiller Q. , Wang D. 
Published: March 2024

AbstractWe conducted a statistical analysis of local phase space density (PSD) minima across a wide energy range (∼20 keVs to ∼10 MeV), using observations from the Van Allen Probes and the Geostationary Operational Environmental Satellite. We identified deepening minima in PSD profiles of multi‐MeV (∼5% occurrence) and of “seed” electrons (up to 15% occurrence, corresponding to ∼70–100 s keV) and compared their distribution with a 3D diffusion model using the Versatile Electron Radiation Belts (VERB) code. The comparison of the observed and modeled distributions suggests that the PSD minima of seed electrons are likely associated with hiss waves and the corresponding L‐shell dependent electron lifetimes. However, the observed distribution was not fully reproduced by the model, potentially indicating other fast loss mechanisms of seed electrons.
aEEG in the first 3 days after extremely preterm delivery relates to neurodevelopmental outcomes
Authors: Pineda Roberta , Vesoulis Zachary , El Ters Nathalie , Mathur Amit 
Published: March 2024

Abstract
Objectives
Investigate relationships between aEEG in the first 72 h in extremely preterm infants with 1) infant, medical, and environmental factors, and 2) infant feeding and neurobehavioral outcomes at term and school-age.

Methods
Sixty-four preterm infants (≤28 weeks gestation) were enrolled within the first 24-hours of life and had two-channel aEEG until 72 h of life. Standardized neurobehavioral and feeding assessments were conducted at term, and parent-reported outcomes were documented at 5–7 years.

Results
Lower aEEG Burdjalov scores (adjusted for gestational age) were related to vaginal delivery (p = 0.04), cerebral injury (p = 0.01), Black race (p < 0.01) and having unmarried parents (p = 0.02). Lower Burdjalov scores related to less NICU Network Neurobehavioral Scale arousal (p = 0.002) at term and poorer BRIEF global executive function (p = 0.004), inhibition (p = 0.007), working memory (p = 0.02), material organization (p = 0.0008), metacognition (p = 0.01), and behavioral regulation (p = 0.02) at 5–7 years. We did not observe relationships of early aEEG to feeding outcomes or sensory processing measures.

Conclusion
Early aEEG within the first 72 h of life was related to medical and sociodemographic factors as well as cognitive outcome at 5–7 years.
The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance
Authors: O’Connor Kevin W. , Kishimoto Kensei , Kuzma Irena O. , Wagner Kelsey P. , Selway Jonathan S. , Roderick Justine E. , Karna Keshab K. , Gallagher Kayleigh M. , Hu Kai , Liu Haibo , Li Rui , Brehm Michael A. , Zhu Lihua Julie , Curtis David J. , Tremblay Cedric S. , Kelliher Michelle A. 
Published: March 2024

AbstractRelapse in T-cell acute lymphoblastic leukemia (T-ALL) may signify the persistence of leukemia-initiating cells (L-ICs). Ectopic TAL1/LMO expression defines the largest subset of T-ALL, but its role in leukemic transformation and its impact on relapse-driving L-ICs remain poorly understood. In TAL1/LMO mouse models, double negative-3 (DN3; CD4−CD8−CD25+CD44−) thymic progenitors harbored L-ICs. However, only a subset of DN3 leukemic cells exhibited L-IC activity, and studies linking L-ICs and chemotolerance are needed. To investigate L-IC heterogeneity, we used mouse models and applied single-cell RNA-sequencing and nucleosome labeling techniques in vivo. We identified a DN3 subpopulation with a cell cycle–restricted profile and heightened TAL1/LMO2 activity, that expressed genes associated with stemness and quiescence. This dormant DN3 subset progressively expanded throughout leukemogenesis, displaying intrinsic chemotolerance and enrichment in genes linked to minimal residual disease. Examination of TAL/LMO patient samples revealed a similar pattern in CD7+CD1a− thymic progenitors, previously recognized for their L-IC activity, demonstrating cell cycle restriction and chemotolerance. Our findings substantiate the emergence of dormant, chemotolerant L-ICs during leukemogenesis, and demonstrate that Tal1 and Lmo2 cooperate to promote DN3 quiescence during the transformation process. This study provides a deeper understanding of TAL1/LMO-induced T-ALL and its clinical implications in therapy failure.
Nonvolatile and reconfigurable two-terminal electro-optic duplex memristor based on III-nitride semiconductors
Authors: Xie Zhiwei , Jiang Ke , Zhang Shanli , Ben Jianwei , Liu Mingrui , Lv Shunpeng , Chen Yang , Jia Yuping , Sun Xiaojuan , Li Dabing 
Published: March 2024

AbstractWith the fast development of artificial intelligence (AI), Internet of things (IOT), etc, there is an urgent need for the technology that can efficiently recognize, store and process a staggering amount of information. The AlScN material has unique advantages including immense remnant polarization, superior temperature stability and good lattice-match to other III-nitrides, making it easy to integrate with the existing advanced III-nitrides material and device technologies. However, due to the large band-gap, strong coercive field, and low photo-generated carrier generation and separation efficiency, it is difficult for AlScN itself to accumulate enough photo-generated carriers at the surface/interface to induce polarization inversion, limiting its application in in-memory sensing and computing. In this work, an electro-optic duplex memristor on a GaN/AlScN hetero-structure based Schottky diode has been realized. This two-terminal memristor shows good electrical and opto-electrical nonvolatility and reconfigurability. For both electrical and opto-electrical modes, the current on/off ratio can reach the magnitude of 104, and the resistance states can be effectively reset, written and long-termly stored. Based on this device, the “IMP” truth table and the logic “False” can be successfully reproduced, indicating the huge potential of the device in the field of in-memory sensing and computing.
Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx
Authors: Xiang Ziqian , Zhang Pengfei , Jia Chunwang , Xu Rongkun , Cao Dingren , Xu Zhaoning , Lu Tingting , Liu Jingwei , Wang Xiaoxiong , Qiu Cheng , Fu Wenyang , Li Weiwei , Cheng Lei , Yang Qiang , Feng Shiqing , Wang Lianlei , Zhao Yunpeng , Liu Xinyu 
Published: March 2024

AbstractTo date, several molecules have been found to facilitate iron influx, while the types of iron influx channels remain to be elucidated. Here, Piezo1 channel was identified as a key iron transporter in response to mechanical stress. Piezo1-mediated iron overload disturbed iron metabolism and exaggerated ferroptosis in nucleus pulposus cells (NPCs). Importantly, Piezo1-induced iron influx was independent of the transferrin receptor (TFRC), a well-recognized iron gatekeeper. Furthermore, pharmacological inactivation of Piezo1 profoundly reduced iron accumulation, alleviated mitochondrial ROS, and suppressed ferroptotic alterations in stimulation of mechanical stress. Moreover, conditional knockout of Piezo1 (Col2a1-CreERT Piezo1flox/flox) attenuated the mechanical injury-induced intervertebral disc degeneration (IVDD). Notably, the protective effect of Piezo1 deficiency in IVDD was dampened in Piezo1/Gpx4 conditional double knockout (cDKO) mice (Col2a1-CreERT Piezo1flox/flox/Gpx4flox/flox). These findings suggest that Piezo1 is a potential determinant of iron influx, indicating that the Piezo1-iron-ferroptosis axis might shed light on the treatment of mechanical stress-induced diseases.
LncRNA SNHG26 promotes gastric cancer progression and metastasis by inducing c-Myc protein translation and an energy metabolism positive feedback loop
Authors: Wu Zhen-Hua , Wang Yi-Xuan , Song Jun-Jiao , Zhao Li-Qin , Zhai Yu-Jia , Liu Yan-Fang , Guo Wei-Jian 
Published: March 2024

AbstractMetastasis is a bottleneck in cancer treatment. Studies have shown the pivotal roles of long noncoding RNAs (lncRNAs) in regulating cancer metastasis; however, our understanding of lncRNAs in gastric cancer (GC) remains limited. RNA-seq was performed on metastasis-inclined GC tissues to uncover metastasis-associated lncRNAs, revealing upregulated small nucleolar RNA host gene 26 (SNHG26) expression, which predicted poor GC patient prognosis. Functional experiments revealed that SNHG26 promoted cellular epithelial–mesenchymal transition and proliferation in vitro and in vivo. Mechanistically, SNHG26 was found to interact with nucleolin (NCL), thereby modulating c-Myc expression by increasing its translation, and in turn promoting energy metabolism via hexokinase 2 (HK2), which facilitates GC malignancy. The increase in energy metabolism supplies sufficient energy to promote c-Myc translation and expression, forming a positive feedback loop. In addition, metabolic and translation inhibitors can block this loop, thus inhibiting cell proliferation and mobility, indicating potential therapeutic prospects in GC.
Pathogenicity of de novo CACNA1D Ca2+ channel variants predicted from sequence co-variation
Authors: Tang Xuechen , Ortner Nadine J. , Nikonishyna Yuliia V. , Fernández-Quintero Monica L. , Kokot Janik , Striessnig Jörg , Liedl Klaus R. 
Published: March 2024

AbstractVoltage-gated L-type Cav1.3 Ca2+ channels support numerous physiological functions including neuronal excitability, sinoatrial node pacemaking, hearing, and hormone secretion. De novo missense mutations in the gene of their pore-forming α1-subunit (CACNA1D) induce severe gating defects which lead to autism spectrum disorder and a more severe neurological disorder with and without endocrine symptoms. The number of CACNA1D variants reported is constantly rising, but their pathogenic potential often remains unclear, which complicates clinical decision-making. Since functional tests are time-consuming and not always available, bioinformatic tools further improving pathogenicity potential prediction of novel variants are needed. Here we employed evolutionary analysis considering sequences of the Cav1.3 α1-subunit throughout the animal kingdom to predict the pathogenicity of human disease-associated CACNA1D missense variants. Co-variation analyses of evolutionary information revealed residue–residue couplings and allowed to generate a score, which correctly predicted previously identified pathogenic variants, supported pathogenicity in variants previously classified as likely pathogenic and even led to the re-classification or re-examination of 18 out of 80 variants previously assessed with clinical and electrophysiological data. Based on the prediction score, we electrophysiologically tested one variant (V584I) and found significant gating changes associated with pathogenic risks. Thus, our co-variation model represents a valuable addition to complement the assessment of the pathogenicity of CACNA1D variants completely independent of clinical diagnoses, electrophysiology, structural or biophysical considerations, and solely based on evolutionary analyses.
Pediatric hypertrophic cardiomyopathy caused by a novel TNNI3 variant
Authors: Inagaki Natsuko , Okano Tomoya , Kobayashi Masatake , Fujii Masatsune , Yazaki Yoshinao , Takei Yasuyoshi , Kosuge Hisanori , Suzuki Shinji , Hayashi Takeharu , Kuroda Masahiko , Satomi Kazuhiro 
Published: March 2024

Abstract

TNNI3 is a gene that causes hypertrophic cardiomyopathy (HCM). A 14-year-old girl who was diagnosed with nonobstructive HCM presented with cardiopulmonary arrest due to ventricular fibrillation. Genetic testing revealed a novel de novo heterozygous missense variant in TNNI3, NM_000363.5:c.583A>T (p.Ile195Phe), which was determined to be the pathogenic variant. The patient exhibited progressive myocardial fibrosis, left ventricular remodeling, and life-threatening arrhythmias. Genetic testing within families is useful for risk stratification in pediatric HCM patients.