bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer survey in south iran with special reference to gastrointestinal neoplasms
Authors: Barekat Ali Asghar , Saidi Farrokh , Dutz Werner 
Published: February 2007

AbstractTo supplement existing data on cancer epidemiology for Iran, a survey covering an 8‐year period (1962–1969) was carried out among the indigenous population of Fars, a southern province of the country. A total of 1,987 male and 1,288 female cancer cases were studied, and the relative frequency of the most common neoplasms compared with that in (1) the capital city, Tehran, (2) a neighboring country, Afghanistan, and (3) a distant western country, Sweden. The most common tumors in order of decreasing frequency were, among males, cancer of the skin, lymphoid system, lung, stomach, bladder, hematopoietic system and esophagus; and among females, cancers of the skin, cervix, breast, lymphoid system, esophagus, hematopoietic system and ovary. The proximal portion of the gastrointestinal tract seemed in general to be more commonly the site of malignant change than the distal part. While the frequency of esophageal cancer was relatively high, there was a paucity of cancer of the colon. For reasons as yet unexplained malignant lymphomas appeared to be among the most common malignant tumors of the bowel.
The effect of polyinosinic: Polycytidylic acid on fluorescent and neutralizing antibodies to herpesvirus saimiri in goats
Authors: Fraser C. E. O. , Meléndez L. V. , Barahona H. H. , Daniel M. D. 
Published: February 2007

AbstractGoats are the best species so far tested for the preparation of fluorescent and neutralizing antibodies to Herpesvirus saimiri. Fluorescent antibodies to Herpesvirus saimiri seem to be different to neutralizing antibodies and polyinosinic: polycytidylic acid (poly I: C) may be of value in separating these two activities.Primary response fluorescent antibodies stained infected monolayers in a characteristic pattern, which is different from that of secondary response antibodies. The immunological and epidemiological implications of this are discussed.
Protection against spontaneous mouse mammary adenocarcinoma by inoculation of heat‐treated syngeneic mammary tumor cells
Authors: Check Jerome H. , Childs T. Craig , Brady Luther W. , Derasse Alain R. , Fuscaldo Kathryn E. 
Published: February 2007

AbstractThe purpose of the study was to determine the effect of the inoculation of syngeneic mouse mammary tumor cells on the incidence of spontaneous tumors and mortality in a group of RIII female mice which normally have a high incidence of primary breast tumors. Animals were inoculated with either untreated, heat‐treated or irradiated tumor cells or a combination of cells. One group received no injections and served as a control.The incidence of tumor development and mortality was recorded for each animal used in the study. Significant delays in tumor onset and subsequent death of the animals were noted in those groups that had been injected with heat‐treated cells as compared to those animals that had been inoculated with non‐heated cells (either irradiated or untreated) or the untreated controls. No detectable differences were found between the groups receiving non‐heated cells and the untreated control group.It was found that the protection derived from inoculation of heat‐treated tumor cells was not due to decreased tumor growth rate, but was more probably related to the destruction of a portion of the tumor cell population.
Deoxyribonucleic acid polymerase associated with feline leukemia and sarcoma viruses: Properties of the enzyme and its product
Authors: Roy‐Burman P. 
Published: February 2007

AbstractNative calf thymus and salmon sperm DNA are better templates than denatured calf thymus and salmon sperm DNA for the DNA‐dependent DNA polymerase activity of feline sarcoma virus. This enzyme activity of feline sarcoma virus and feline leukemia virus faithfully replicates dAT copolymer to synthesize a sequence of alternate deoxyadenylate‐deoxythymidylate. With a homopolymeric duplex, polydA.dT, the DNA‐directed enzyme from feline sarcoma virus or feline leukemia virus indicates a requirement for simultaneous copying of both template strands.
Mammotropic and somatotropic hormones in sera of normal rats and in rats bearing primary and grafted pituitary tumors
Authors: Ito A. , Martin J. M. , Grindeland R. E. , Takizawa S. , Furth J. 
Published: February 2007

AbstractParallel determinations were made of the concentration of MtH and StH in the sera of rats with spontaneous, estrogen‐induced and grafted pituitary tumors and, for a base, in sera of normal rats of both sexes, in various physiologic states, following oophorectomy and treatment with gonadal hormones.The characteristic sharp rise of MtH during proestrus was confirmed. This was not accompanied by a rise in StH.Following oophorectomy the levels of both hormones dropped. After estrogen treatment of normal rats, both hormones rose gradually, reaching very high levels with development of pituitary tumors. Similar increases were found with spontaneous mammotropic tumors (MtH) in rats of both sexes.Seven MtT's, originating in six different strains, were studied in the course of successive transplantations. All exhibited mammary gland stimulation, with very high MtH and StH levels, depending on the tumor size and tumor strain. In general, hormone secretion decreased in the course of successive transplantations.One variant of the originally typical MtT.W5, MtT.W5/H, markedly lost the ability to produce MtH while maintaining the ability to produce StH, as indicated by both radioimmunoassays and biological changes in the tumor hosts. The oldest transplantable tumor of this series (MtT.F4), secreted large quantities of AtH and StH without biological evidence of somatotropic effects. The StH effect became “unmasked” by adrenalectomy. Biological evidence of AtH secretion by the other MtH strains was inconstant and variable. It was often present in the first transplant generation but vanished in the course of successive transplantations with the exception of the F4 strain.The MtH values in normal as well as MtT‐bearing hosts were higher in female than in male rats. There was relatively more StH in males than in females.
Tissue‐dependent differences in dna methylation products of mice treated with methyl‐labelled methylnitrosourea
Authors: Frei Jaroslav V. 
Published: February 2007

AbstractAdult inbred Swiss mice were given a single carcinogenic dose of methyl‐labelled methylnitrosourea in the range of doses which induces thymic lymphomas, lung adenomas and other random malignant tumours. DNA was extracted from pooled bone marrow, spleens, thymuses, kidneys, livers, or lungs within 1 h of injection and was hydrolysed and chromatographed to demonstrate the proportions of three products: 7‐methylguanine, 3‐methyladenine, and 6‐methoxyguanine. Disproportionately high relative amounts of 3‐methyladenine were found in the tissues thought to have a role in the genesis of thymic lymphomas. 6‐methoxyguanine, which Loveless (1969) postulates to be the product crucial for carcinogenesis, was detected in the DNA of all tissues examined. The possible usefulness of this approach to the study of carcinogenesis was thus demonstrated.
Étude de la Leucémogénèse akr a l'aide d'un marqueur cytogénétique
Authors: Legrand E. , Duplan J. F. 
Published: February 2007

AbstractAKR‐TIALD mice bearing 38 chromosomes with 2 metacentrics are irradiated and restored with AKR (40 acrocentrics) bone marrow. These isogenic radiation chimaeras provide the opportunity to perform a cytogenetic study in order to determine the origin of the cells, the chronology of bone marrow thymus, and lymph node repopulation as well as of the leukaemic process. In AKR/TIALD chimaeras the repopulation of the lymphatic system follows the same steps as previously described in CBA/T6‐T6.The lymphatic leukaemias induced by 4 irradiations of 175 R may be divided into three groups according to their latencies: (a) Early or radiation‐induced leukaemias which may originate from either host cells or donor cells or both (mixed leukaemias), (b) the leukaemias which appear between 180 and 220 days and belong mainly to host cells, (c) late leukaemias, posterior to 220 days, the cells of which are of donor origin.Most leukaemias of host origin precede the leukaemias of donor origin because the cells of the latter must differentiate from the injected stem cells which first repopulate bone marrow into more mature elements which secondarily migrate into the thymic cortex where the lymphosarcomatous foci originate.The results of an experiment where T1ALD mice were restored with an equal number of AKR and T1ALD bone marrow cells, point to the possible multifocal origin of the leukaemia. T1ALD cells have the same sensitivity to X radiation and to Gross virus than the cells from conventional AKR mice.
The effects of protease I of Aspergillus oryzae (brinase) on membrane permeability and growth of landschütz ascites tumour cells
Authors: Smyth Honor , Flahavan Eleanor , Thornes R. D. 
Published: February 2007

AbstractLandschütz ascites tumour cells treated in vitro with Protease I showed no changes in intracellular K and Na levels when the cells were analysed directly at the end of the 60‐min incubation period. If, however, the cells were washed twice in the saline medium before analysis significant losses of K, apparently in exchange for Na, were found to take place. Controls incubated in the absence of Protease I and similarly treated showed no such K loss. Viability tests, using lissamine green, indicated that the observed changes were not due to dead cells. These findings are interpreted as being due to an alteration in the plasma membrane associated with increased sensitivity to mechanical trauma, which in turn leads to secondary loss of K. Increases in UV absorbance in the 260 nm region were noted in the supernatant medium of treated cells.Normal mice weighing 30 g tolerated intraperitoneal injections of 0.3 mg Protease I and under, in repeated daily doses, but a single injection of 0.4 (i.e. 13 mg/kg) was lethal within 2 hours. The presence of tumour cells (7.5 mg dry wt) intraperitoneally was found to protect mice against repeated daily injections of this normally lethal dose, indicating that the enzyme is quickly adsorbed onto the tumour cells. No effect on tumour growth in vivo was found when single injections of Protease I were administered intraperitoneally at the same time as the tumour, but when additional doses of the enzyme were given on the two subsequent days, the 7‐day yield of tumour cells was significantly increased.
Histochemistry of giant cells in tumours induced in golden hamsters by murine sarcoma virus‐harvey
Authors: Hallowes R. C. , Chesterman F. C. 
Published: February 2007

AbstractTumours induced by murine sarcoma virus‐Harvey (MSV‐H) in golden hamsters are characterized by the presence of multinucleate giant cells. A histochemical study was undertaken to determine the relationship of the giant cells to each other and to the surrounding tumour. It was shown that the giant cells were not a homogeneous cell population. Those found in subcutaneous tumours showed no substrate‐specific phosphatases and had marked histochemical similarity to cells of the adjacent tumour. In paw, muscle and bone‐eroding tumours, most of the giant cells showed strong substrate‐specific phosphatase activity and no histochemical resemblance to cells of the adjacent tumour. Giant cells probably related to skeletal muscle were seen only where muscle was infiltrated by tumour. It was concluded that the giant cells were possibly related to the tumour cells only in the case of the subcutaneous tumours and that in the other tumours they were probably related to macrophages.
Spontaneous and adenovirus type 12‐induced chromosome aberrations in fanconi's anaemia fibroblasts
Authors: McDougall J. K. 
Published: February 2007

AbstractThe spontaneous aberrations which occur in cells from patients with Fanconi's anaemia have been shown to be distributed in a random manner. Adenovirus type 12‐induced chromosome aberrations are non‐random in cells from patients with Fanconi's anaemia and there is a high degree of specificity for a site on the No. 17 chromosome, as is found in cytogenetically normal human cells.Although foci of infected cells were found in long‐term Fanconi cultures there was no evidence of viral transformation.
Cell‐mediated and humoral immune responses to tumor‐associated and viral antigens in relation to the pathogenic effect of rous sarcoma virus in rats
Authors: Jonsson Nils 
Published: February 2007

AbstractAfter inoculation of the Schmidt‐Ruppin strain of Rous sarcoma virus (SR‐RSV) into a series of newborn rats (strain R/F) sarcomas developed in 47% of the animals, half of which also had hemorrhagic‐cystic lesions. In 18% such hemorrhagic cysts occurred without demonstrable tumors, while no pathogenic effect of the virus was observed in the rest of the animals.The colony inhibition technique was used to detect lymph‐node cell (LNC)‐mediated and humoral immunity to the tumor‐associated transplantation antigen (s). LNC‐mediated immunity could be demonstrated in a high proportion of tumor‐positive as well as tumor‐negative rats (83 and 94%, respectively), while the rats with hemorrhagic‐cystic lesions showed such immunity in a lower frequency (56%). Humoral cytotoxic activity could be demonstrated in a higher frequency in rats with cystic lesions than in rats without cysts, whether they had tumors or not (about 80 and 55%, respectively). Antiviral immune response was demonstrable in only a few animals.The results indicate that, as in several other systems, the development of tumors is not related to a deficient LNC‐mediated immune response to the tumor‐associated transplantation antigen (s). Nor could any difference be demonstrated in the frequency of humoral immune response to the antigen (s) between tumor‐positive and tumor‐negative animals. The results furthermore indicate that the hemorrhagic‐cystic lesions, characteristic for the RSV effect, develop in animals which have a less efficient LNC‐mediated immune response and that these lesions are of importance for the sustaining of humoral cytotoxic immune response.
Karyological patterns and expression of malignancy in some homologous mouse somatic hybrid cells
Authors: Belehradek Jean , Barski Georges 
Published: February 2007

AbstractA homologous mouse somatic hybrid cell line (HyEN) was developed in mixed cultures of C3H mouse malignant cell line crossed with a BALB/c mouse non‐tumorigenic cell line. An attempt was made to establish a possible relationship between the karyological features and die malignancy expression in this hybrid cell line as well as in six clones derived from it. As a rule, the karyotypes of the HyEN hybrid line and of its clones showed a marked dispersion of chromosome numbers and their modal values ranged from 80 to 129, the presumed “ideal” sum of the parental cell modes being 122. The HyEN line had a mode of 116 chromosomes and produced tumors when inoculated into histocompatible F1mice. Among the six randomly isolated hybrid clones studied, the only non‐tumor‐producing one had a mode of 112–118, quite similar to those of two other malignant clones. Three more clones were malignant and had modes of 80, 98 and 129 chromosomes. Early cultures of cells recovered from these different tumors obtained were likewise submitted to karyological analysis which showed a tendency to a decrease in chromosomal mode values after passage in vivo. A similar though less important tendency was noted following in vitro passages of the original HyEN line as well as of its clones. However, in spite of the general tendency toward chromosomal loss, the hybrid cells participating in the formation of tumors represented a wide range of chromosomal variants and no conclusion could be reached concerning a definite relationship between chromosomal deletion and malignancy of the hybrid cells.
Host response to challenge with SA7‐induced autochthonous tumor cells
Authors: Lausch Robert N. , Jerkofsky Mary Ann , Haughton Dennis , Cody Robert 
Published: February 2007

AbstractThe fate of SA7‐induced autochthonous tumor transplants in inbred hamsters (strain LSH) was determined. It was found that the host response to tumor autografts was not uniform. Out of a series of 30 such transplants, evidence for host resistance was found in 12 instances. Conversely, in six cases the tumor cell inoculum grew only or more rapidly in the autochthonous host. In three tests the challenge tumor growth rate was similar in both autochthonous and control (s), and in nine trials neoplasms did not develop in either recipient. In the last category the failure of the tumor cells to grow was most likely due to host resistance rather than to poor transplantability because it was found that SA7 tumor lines which were poorly oncogenic or non‐oncogenic in adult animals invariably produced lethal tumors in infant hamsters. It was concluded that a) hamsters can manifest autochthonous tumor immunity to SA7‐induced neoplasms and b) one factor which contributed to the diversity of the host response was the size of the primary tumor prior to and shortly after grafting.
Studies of the EB virus‐related antigens of human leukocyte cell lines
Authors: Walters Marilyn K. , Pope J. H. 
Published: February 2007

AbstractThe complement‐fixing (CF) antigens of five human leukocyte cell lines were studied. Three components were recognized in the EB virus‐rich QIMR‐WIL line. First, a virion component harvested from sucrose density gradients was resistant to heating at 56° C for 30 min. Second, a heat‐labile CF component detected was subviral but sedimentable at 70,000 × g for 2 h. Third, a heat‐resistant soluble CF antigen was present. In contrast to the QIMR‐WIL line, the virus‐free Raji line contained only the heat‐resistant soluble antigen. Labile CF antigen was also detected in the EB virus‐positive QIMR‐GOR line and in the QIMR‐STE and TFT‐1 lines in which the presence of EB virus was suggested by immunofluorescence tests. The presence in leukocyte cell lines of heat‐labile EB viral CF antigen is considered to be a useful indicator of active replication of EB virus. Evidence obtained suggested that naked virus was capable of transforming human leukocytes.
Effects of lasiocarpine on protein synthesis tn rat liver
Authors: Demarle Ana , Moulé Yvonne 
Published: February 2007

AbstractA single dose of lasiocarpine corresponding to 1 LD50 (80 mg/kg body weight) strongly inhibits protein synthesis in rat liver as early as 15 min after administration. Maximal inhibition was found between 1 and 3 h; thereafter a progressive recovery occurs with time.In lasiocarpine‐treated rats, the pattern of distribution of total liver RNP shows that the relative amount of polysomes decreases whereas ribosomal subunits and 80 S monomers are markedly enhanced. However, it has been found that breakdown of polysomes only concerns the free aggregates; the bound polysomes are apparently unaffected by the drug.Moreover, amino acid incorporation is depressed in a cell‐free system derived from lasiocarpine‐treated rats; it is suggested that this effect is due to a functional impairment in the polysome itself rather than in the activity of the soluble enzymes involved in the translation process. The results are discussed in the light of the different hypotheses which could explain the short‐term effects and the long‐term carcinogenic property of lasiocarpine.
Immunosuppression by the radiation leukemia virus and its relation to lymphatic leukemia development
Authors: Peled Alpha , Haran‐Ghera Nechama 
Published: February 2007

AbstractThe immune response of C57BL/6 mice following intra‐thymic injection of the radiation leukemia virus was tested. A marked depression in plaque‐forming capacity of the 19S type to sheep red cells was observed in adult intact and thymectomized mice inoculated with the virus 5–60 days prior to the immunization. Serum hemagglutinin titers were depressed as well, but to a lesser degree.The radiation leukemia virus did not significantly depress cell‐mediated immunity. Tests for prolongation of skin allograft survival, allogeneic tumor takes and graft‐versus‐host reactivity (Simonsen's test) were used as parameters for the evaluation of defects in cellular immunity.No correlation was found between the immunosuppressive effect of the radiation leukemia virus and lymphatic leukemia development.It is proposed that the decrease observed, with aging, in the immune response of normal C57BL mice, to sheep red cells, is due to the radiation leukemia virus that is present during post‐natal life in non‐irradiated C57BL mice, and that its titer increases with aging.
The effects of oronasal administration of two strains of murine sarcoma virus in mice
Authors: McCully D. J. , Simons P. J. , Ingram J. D. 
Published: February 2007

AbstractOronasal administration of MSV‐H produced pathological changes in the lungs, mediastinum, gastric mucosa, spleen and brain. The early pulmonary changes showed intra‐alveolar haemorrhage, then organization forming a “granuloma” and finally a circumscribed lesion containing predominantly vasoformative tissue. Similar vasoformative lesions were seen in the perinodal areas of the medimtinum. MSV‐M lesions were found only in muscb and were of an inflammatory and reparative type of reaction. The significance of these findings is discussed.
Kaposi's sarcoma in Uganda: A clinico‐pathological study
Authors: Taylor John F. , Templeton Alexander C. , Vogel Charles L. , Ziegler John L. , Kyalwazi Sebastian K. 
Published: February 2007

AbstractThirty‐seven Ugandan Africans with Kaposi's sarcoma were studied prospectively and a clinical classification was devised based on the clinical presentation of the disease and the appearance of the cutaneous tumours. The disease could be sub‐classified into four major groups. The first consisted of patients with nodular disease which was associated with a relatively benign clinical course. Patients in the next two groups (florid and infiltrative) had more aggressive disease with extensive cutaneous lesions on one or more extremities, generally associated with involvement of adjacent bone. Cutaneous lesions in the florid group were exophytic tumours while in the infiltrative group deep lesions associated with dense fibrosis predominated, Finally, the lymph‐adenopathic variety occurred mainly in children where lymph‐node involvement was usually the sole manifestation, and in young adults where skin involvement was seen concomitantly. Differing histological patterns were found to correlate with the four clinical types of involvement.
Time trends of intestinal and diffuse types of gastric cancer in Norway
Authors: Muñoz N. , Asvall J. 
Published: February 2007

AbstractSamples of gastric cancer from three time periods (1940–1944, 1952–1953 and 1964–1966) were drawn from material of the Norwegian Radium Hospital, representing specimens collected from different hospitals throughout the country. The cases were diagnosed as belonging to the “intestinal”, “diffuse” or “other” category according to the classification of Laurén (1965). It was found that the three types showed about the same relative frequency from the first to the second time period, the intestinal one being the most common. However, from the second to the third time period the intestinal type decreased very markedly, in particular in the youngest age group.Figures are presented showing that for both males and females the death rate from gastric cancer fell from the early 1930s to the middle of the 1960s, but that this trend stopped temporarily during the latter half of the 1940s. It is concluded that this could well be due to dietary changes during the 1940–1945 war, influencing mainly the intestinal type. Such changes are probably not related to protein deficiency or lack of Vitamin A, but they could depend on factors in cereals, milk or fat.It is concluded that the long‐term, pronounced decline of gastric cancer death observed in Norway for several decades may soon begin to level of, leaving a “hard core” of very slowly decreasing “diffuse” and “other” types.