bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of advancing the standard of care in radiotherapy on operational treatment resources
Authors: Roumeliotis Michael , Thind Kundan , Morrison Hali , Burke Ben , Martell Kevin , van Dyke Lukas , Barbera Lisa , Quirk Sarah 
Published: April 2024

AbstractPurposeTo demonstrate the impact of implementing hypofractionated prescription regimens and advanced treatment techniques on institutional operational hours and radiotherapy personnel resources in a multi‐institutional setting. The study may be used to describe the impact of advancing the standard of care with modern radiotherapy techniques on patient and staff resources.MethodsThis study uses radiation therapy data extracted from the radiotherapy information system from two tertiary care, university‐affiliated cancer centers from 2012 to 2021. Across all patients in the analysis, the average fraction number for curative and palliative patients was reported each year in the decade. Also, the institutional operational treatment hours are reported for both centers. A sub‐analysis for curative intent breast and lung radiotherapy patients was performed to contextualize the impact of changes to imaging, motion management, and treatment technique.ResultsFrom 2012 to 2021, Center 1 had 42 214 patient plans and Center 2 had 43 252 patient plans included in the analysis. Averaged over both centers across the decade, the average fraction number per patient decreased from 6.9 to 5.2 (25%) and 21.8 to 17.2 (21%) for palliative and curative patients, respectively. The operational treatment hours for both institutions increased from 8 h 15 min to 9 h 45 min (18%), despite a patient population increase of 45%.ConclusionThe clinical implementation of hypofractionated treatment regimens has successfully reduced the radiotherapy workload and operational treatment hours required to treat patients. This analysis describes the impact of changes to the standard of care on institutional resources.
3D localization of wireless sensor IoT nodes based on weighted DV‐Hop algorithm
Authors: Zhang Kui , Cui Haihua , Yan Xiaomei 
Published: April 2024

AbstractWith the widespread popularity of smart wearable devices and the rise of emerging Internet of Things applications, such as smart cities, smart homes, and smart cars, the demand for Internet of Things devices is growing. The technology for positioning Internet of Things nodes using traditional wireless sensors only provides approximate location information, which is insufficient for high‐precision applications. To achieve accurate sensor node location in a specific area, this study proposes an advanced weighted distance vector jump location algorithm. This paper proposes using optical wireless networks, a new wireless communication technology, to enhance the distance vector jump algorithm. It is considered the core technology in researching the three‐dimensional positioning of wireless sensor IoT nodes. The experimental data validated that by comparing with existing positioning algorithms, the improved algorithm significantly improved the location accuracy, and its average orientation error was significantly lower than other algorithms. In three cases where the wireless sensor communication radius was between 10 and 30 m, the average positioning errors of the improved algorithm were 0.363, 0.264, and 0.258, respectively. Compared with the pre improved Distance Vector Hop algorithm, its accuracy has increased by 41.1%, indicating the better positioning performance. Overall, the improved weighted algorithm significantly improves the positioning effect, providing strong technical support for the three‐dimensional positioning of wireless sensor Internet of Things nodes.
Perylene Diimide‐Based Low‐Cost and Thickness‐Tolerant Electron Transport Layer Enables Polymer Solar Cells Approaching 19% Efficiency
Authors: Zhang Bin , Zhao Yushou , Xu Congdi , Feng Chuang , Li Wenming , Qin Xiaofeng , Lv Menglan , Luo Xuanyan , Qin Xiaolan , Li Aiqing , He Zhicai , Wang Ergang 
Published: April 2024

AbstractThe materials for electron transport layers (ETLs) play a significant role in the performance of polymer solar cells (PSCs) but face challenges, such as low electron transport mobility and conductivity, low solution processibility, and extreme thickness sensitivity, which will undermine the photovoltaic performance and hinder compatibility of large‐scale fabrication technique. To address these challenges, a new n‐type perylene diimide‐based molecule (PDINB) with two special amine‐anchored long‐side chains is designed and synthesized feasibly. PDINB shows very high solubility in common organic solvents, such as dichloromethane (>75 mg ml−1) and methanol with acetic acid as an additive (>37 mg ml−1), which leads to excellent film formability when deposited on active layers. With PDINB as ETLs, the photovoltaic performance of the PSCs is boosted comprehensively, leading to power conversion efficiency (PCE) up to 18.81%. Thanks to the strong self‐doping effect and high conductivity of PDINB, it displays an appreciable thickness‐tolerant property as ETLs, where the devices remain consistently high PCE values with the thickness varying from 5 to 30 nm. Interestingly, PDINB can be used as a generic ETL in different types of PSCs including non‐fullerene PSCs and all‐polymer PSCs. Therefore, PDINB can be a potentially competitive candidate as an efficient ETL for PSCs.
“Reactive” Chemical Strategy to Attain Substrate Independent “Liquid‐Like” Omniphobic Solid Anti‐Biofouling Coatings
Authors: Shome Arpita , Martinez Isabel , Pinon Vicente D. , Moses Joseph C , Garren Mark , Sapkota Aasma , Crutchfield Natalie , Francis Divine J. , Brisbois Elizabeth J. , Handa Hitesh 
Published: April 2024

AbstractCovalent and defect‐free surface‐grafted solid lubricating chains that can impart “liquid‐like” slippery behavior have proven advantageous over lubricant‐infused and textured anti‐wetting surfaces. Herein, the co‐hydrolysis and co‐condensation of a mixture of organosilanes followed by the epoxy‐amine ring opening reaction at the interface results in a highly robust, transparent, and “liquid‐like” solid slippery omniphobic coating (LL‐OSC). The presence of the epoxy‐terminated organosilane a) acts as a molecular spacer in between the low‐surface energy, rigid fluorine terminated silane and b) provides “reactive” epoxy groups for covalent binding to a pre‐functionalized amine surface for potential applicability in droplet transport and manipulation, diagnostics, etc. LL‐OSC exhibits resistance to both solid and liquid abrasions such as sandpaper abrasions, prolonged UV irradiation, DI water and high temperature (30 days), and submersion in chemically contaminated aqueous solutions. This is the first report of a hemocompatible solid slippery coating for inhibiting platelet adhesion, thus, paving way for blood‐contacting medical device applications. The LL‐OSC exhibits remarkable cytocompatibility, repellence to plasma protein, and cells and prevents biofilm formation. Additionally, the substrate‐independent LL‐OSC can be applied onto metals and polymers. This study envisions that the reported durable, solid slippery coating will find widespread applicability in hospital settings, electronic devices, etc.
Dynamic Anion Enables Self‐Healing Single‐Ion Conductor Polymer Electrolyte for Lithium‐Metal Batteries
Authors: Duan Ping‐Hui , Yu Jia‐Ling , Liu Qing‐Song , Wu Gang , Wang Xiu‐Li , Wang Yu‐Zhong 
Published: April 2024

AbstractLithium‐metal batteries (LMBs) are regarded as a promising option for high‐energy‐density storage systems. However, lithium dendrite growth in LMBs can damage electrolytes and cause short circuits, which severely limits the practical application of LMBs. It is highly desired to develop an advanced polymer electrolyte with self‐healing capability and the ability to inhibit the growth of lithium dendrites for enhancing safety and prolonging the cycle life of the LMBs. Herein, sp3 boron‐based single‐ion conductor polymer electrolytes (B‐SIPEs) with excellent self‐healing capability and interfacial stability are constructed. The rapid bond exchange reactions of dynamic borate anions enable B‐SIPE to fast self‐heal in mild conditions, with a high self‐healing efficiency of 87% within 30 min at an ambient temperature. In particular, B‐SIPE displays a high Li+ transference number (0.88) and excellent lithium dendrite inhibition ability. The Li|B‐SIPE|Li cells exhibit a stable overpotential over 2000 h without short‐circuit. Additionally, the LiFePO4||Li cells with B‐SIPE exhibit superior long‐term cycling performance, with 93.5% capacity retention for 500 cycles. Significantly, B‐SIPE is capable of self‐healing the fracture in LiFePO4||Li cells and recovering the battery performance. These results demonstrate that the advanced self‐healing single‐ion conductor polymer electrolytes effectively promote the reliability and safety of LMBs.
Microphase Separation 3D Printing of Binary Inorganic Polymer Precursors to Prepare Nanostructured Carbon‐Ceramic Multimaterials
Authors: Bobrin Valentin A. , Hackbarth Haira G. , Bonsu Jacob O. , Yao Yin , Bedford Nicholas M. , Kundu Dipan , Zhang Jin , Corrigan Nathaniel , Boyer Cyrille 
Published: April 2024

AbstractTraditionally, combining carbon and ceramic materials has been challenging due to their different chemical and physical properties. Despite the development of numerous methodologies for their synthesis, these techniques frequently necessitate intricate, multi‐stage protocols and specialized equipment. This study introduces a novel approach for fabricating nanostructured carbon‐ceramic multimaterials through polymerization‐induced microphase separation 3D printing. By combining inorganic precursors, polycarbosilane, and acrylonitrile (AN) within a photocurable resin, heterogeneous nanostructured materials composed of PAN‐preceramic and sacrificial polymer phases are 3D printed. Upon pyrolysis, PAN‐preceramic domains transformed into a carbon‐ceramic matrix while sacrificial polymer domains thermally decomposed to yield nanoscale voids. The utilization of synchrotron X‐ray spectroscopy and microscopy techniques revealed that the phase compositions and microstructure of the resulting multi‐materials are significantly influenced by the initial composition of the resins. The co‐existence of ceramic and carbon phases within a single 3D printed material brought together a combination of properties from both phases, such as the low thermal conductivity of ceramics and the relatively high electrical conductivity of carbon, along with the exceptional chemical resistance. The insights into the microstructure, atomic configuration, and property relationships of the resulting materials have broad implications for the development of multi‐phase nanostructured hybrid materials.
Tau Aggregation‐Dependent Lipid Peroxide Accumulation Driven by the hsa_circ_0001546/14‐3‐3/CAMK2D/Tau Complex Inhibits Epithelial Ovarian Cancer Peritoneal Metastasis
Authors: Chai BinShu , Wu Yong , Yang HengHui , Fan BiaoFeng , Cao SiYu , Zhang XiaoFei , Xie YaQing , Hu ZhiXiang , Ma ZhongLiang , Zhang YunKui , Pan Wei , Meng Wei , Meng Jiao , Tian WenJuan , Zhang JiaLi , Li YanLi , Shao Yang , Wang ShaoJia 
Published: April 2024

AbstractIntraperitoneal dissemination is the main method of epithelial ovarian cancer (EOC) metastasis, which is related to poor prognosis and a high recurrence rate. Circular RNAs (circRNAs) are a novel class of endogenous RNAs with covalently closed loop structures that are implicated in the regulation of tumor development. In this study, hsa_circ_0001546 is downregulated in EOC primary and metastatic tissues vs. control tissues and this phenotype has a favorable effect on EOC OS and DFS. hsa_circ_0001546 can directly bind with 14‐3‐3 proteins to act as a chaperone molecule and has a limited positive effect on 14‐3‐3 protein stability. This complex recruits CAMK2D to induce the Ser324 phosphorylation of Tau proteins, changing the phosphorylation status of Tau bound to 14‐3‐3 and ultimately forming the hsa_circ_0001546/14‐3‐3/CAMK2D/Tau complex. The existence of this complex stimulates the production of Tau aggregation, which then induces the accumulation of lipid peroxides (LPOs) and causes LPO‐dependent ferroptosis. In vivo, treatment with ferrostatin‐1 and TRx0237 rescued the inhibitory effect of hsa_circ_0001546 on EOC cell spreading. Therefore, based on this results, ferroptosis caused by Tau aggregation occurs in EOC cells, which is not only in Alzheimer's disease‐ or Parkinson's disease‐related cells and this kind of ferroptosis driven by the hsa_circ_0001546/14‐3‐3/CAMK2D/Tau complex is LPO‐dependent rather than GPX4‐dependent is hypothesized.
Salinity tolerance, growth and survival of three Artemia franciscana (Kellogg, 1906) populations under laboratory conditions
Authors: Ngarari Morine M. , Hinzano Sheban M. , Opiyo Mary A. , Rugendo Derrick G. , Midumbi David O. , Okalo Francis A. , Nyonje Betty M. , Ngugi Charles C. , Gatune Charles W. 
Published: April 2024

AbstractIn the 1980s, Artemia franciscana from San Francisco Bay (SFB) was introduced into Kenyan saltworks, where it has colonized and established stable populations. However, little is known about its biology, particularly with respect to its parental SFB population. This study compared the salinity tolerances of Kenyan (KEN) population, their SFB progenitors and those of Great Salt Lake (GSL) populations. Growth and survival of these A. franciscana populations were evaluated under varying salinity levels in a laboratory set up. A. franciscana nauplii were cultured at a rate of 1 nauplii/mL in 36 Erlenmeyer flasks and fed microalgae (Chaetoceros sp.) at 1.5 × 106 cells/animal/day for 8 days. Survival was evaluated daily and survivors were fixed in individual vials with Lugol solution. The total length of each fixed A. franciscana nauplii specimen was measured under a compound microscope. All populations were susceptible to salinities greater than 100 g/L. Compared with the parental SFB population, the KEN population exhibited significantly reduced survival and growth at 140 g/L, suggesting a narrower salinity tolerance range. These findings underscore the need for further studies focusing on other physiological parameters, abiotic factors and genetic characterization to confirm whether the KEN population is experiencing ecological adaptation. This will contribute to the optimization of Artemia practices in various salinity environments as a result of climate change.
Heterotic growth of hybrids of Arabidopsis thaliana is enhanced by elevated atmospheric CO2
Authors: Mishio Masako , Sudo Emi , Ozaki Hiroshi , Oguchi Riichi , Fujimoto Ryo , Fujii Nobuharu , Hikosaka Kouki 
Published: April 2024

AbstractPremiseWith the global atmospheric CO2 concentration on the rise, developing crops that can thrive in elevated CO2 has become paramount. We investigated the potential of hybridization as a strategy for creating crops with improved growth in predicted elevated atmospheric CO2.MethodsWe grew parent accessions and their F1 hybrids of Arabidopsis thaliana in ambient and elevated atmospheric CO2 and analyzed numerous growth traits to assess their productivity and underlying mechanisms.ResultsThe heterotic increase in total dry mass, relative growth rate and leaf net assimilation rate was significantly greater in elevated CO2 than in ambient CO2. The CO2 response of net assimilation rate was positively correlated with the CO2 response of leaf nitrogen productivity and with that of leaf traits such as leaf size and thickness, suggesting that hybridization‐induced changes in leaf traits greatly affected the improved performance in elevated CO2.ConclusionsVegetative growth of hybrids seems to be enhanced in elevated CO2 due to improved photosynthetic nitrogen‐use efficiency compared with parents. The results suggest that hybrid crops should be well‐suited for future conditions, but hybrid weeds may also be more competitive.
Presynaptic density determined by SV2A PET is closely associated with postsynaptic metabotropic glutamate receptor 5 availability and independent of amyloid pathology in early cognitive impairment
Authors: Wang Jie , Huang Qi , He Kun , Li Junpeng , Guo Tengfei , Yang Yang , Lin Zengping , Li Songye , Vanderlinden Greet , Huang Yiyun , Van Laere Koen , Guan Yihui , Guo Qihao , Ni Ruiqing , Li Binying , Xie Fang 
Published: April 2024

AbstractINTRODUCTIONMetabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling and relevant synaptic failure play a key role in the pathophysiological mechanism of Alzheimer's disease (AD).METHODSTen cognitively impaired (CI) individuals and 10 healthy controls (HCs) underwent [18F]SynVesT‐1 and [18F]PSS232 positron emission tomography (PET)/magnetic resonance to assess synaptic density and mGluR5 availability. The associations between mGluR5 availability and synaptic density were examined. A mediation analysis was performed to investigate the possible mediating effects of mGluR5 availability and synaptic loss on the relationship between amyloid deposition and cognition.RESULTSCI patients exhibited lower mGluR5 availability and synaptic density in the medial temporal lobe than HCs. Regional synaptic density was closely associated with regional mGluR5 availability. mGluR5 availability and synaptic loss partially mediated the relationship between amyloid deposition and cognition.CONCLUSIONSReductions in mGluR5 availability and synaptic density exhibit similar spatial patterns in AD and are closely linked.Highlights
Cognitively impaired patients exhibited lower mGluR5 availability and synaptic density in the medial temporal lobe than HCs.
Reductions in mGluR5 availability and synaptic density exhibit similar spatial patterns in AD.
Regional synaptic density was closely associated with regional mGluR5 availability.
mGluR5 availability and synaptic loss partially mediated the relationship between amyloid deposition and global cognition.
With further research, modulating mGluR5 availability might be a potential therapeutic strategy for improving synaptic function in AD.
Blue Long Afterglow and Ultra Broadband Vis‐NIR Emission from All‐Inorganic Copper‐Doped Silver Halide Single Crystals
Authors: Wang Sijia , Liu Runze , Li Juntao , Meng Caixia , Liu Jianyong , Chen Junsheng , Cheng Pengfei , Wu Kaifeng 
Published: April 2024

AbstractAll‐inorganic metal halides with afterglow emission have attracted increasing attention due to their significantly longer afterglow duration and higher stability compared to their organic–inorganic hybrid counterparts. However, their afterglow colors have not yet reached the blue spectral region. Here, we report all‐inorganic copper‐doped Rb2AgBr3 single crystals with ultralong blue afterglow (>300 s) by modulating defect states through doping engineering. The introduction of copper(I) ions into Rb2AgBr3 facilitates the formation of bromine vacancies, thus increasing the density of trap states available for charge storage and enabling bright, persistent emission after ceasing the excitation. Moreover, cascade energy transfer between distinct emissive centers in the crystals results in ultra‐broadband photoluminescence, not only covering the whole white light with near‐unity quantum yield but also extending into the near‐infrared region. This ‘cocktail’ of exotic light‐emission properties, in conjunction with the excellent stability of copper‐doped Rb2AgBr3 crystals, allowed us to demonstrate their implementation to solid‐state lighting, night vision, and intelligent anti‐counterfeiting.
Long‐chain polyester dicarboxylic acid‐induced rapid transesterification chemistry of biobased epoxy system for improved self‐repairing performances
Authors: Zhao Shujun , Qu Jiehao , Yin Shengjiong , Liu Xiangdong , Zhu Hu 
Published: April 2024

AbstractConstructing self‐repairing epoxy materials based on transesterification chemistry can be regarded as a potential path for practical industrial applications given on its simplicity and ease of processing. However, there is still a challenge to improve the slow bonding exchange process for desired healing performances. Herein, this work reports a simple and effective strategy to prepare high‐biomass‐content self‐repairing epoxy materials by introducing polyester oligomer (PEO) dicarboxylic acid as modifier into epoxidized soybean oil and itaconic acid compounds. The PEO is synthesized from glutaric anhydride and 1,4‐cyclohexanediol, as well possess a unique pentamer molecular structure. It not only endows the epoxy system with improved molecular mobility in virtue of its long‐chain structure, but also increases the number the essential ester groups of transesterification process, thus synergistically promoting bonding exchange rate for expected properties. As a result, the employment of PEO decreases the activation energy from 100 to 70 KJ/mol, as well as presents optimized self‐repairing efficiency in storage modulus and tensile strength tests compared to the control group. It may provide a new and practical way to fabricate high‐effective self‐repairing epoxy system for industrial applications.
Fluorescence emission angular dependence on a nanostructured plasmonic grating
Authors: Angelini Margherita , Manobianco Eliana , Pellacani Paola , Floris Francesco , Marabelli Franco 
Published: April 2024

AbstractPlasmonic gratings provide an advantageous platform for fluorescence sensing due to their compatibility with functionalization techniques, imaging detection, and the potential for signal enhancement. Among traditional fluorescence detection methods, microscopes are commonly used tools. The interaction between dye fluorescence processes and the plasmonic modes of the grating strongly depends on the measurement configuration and is influenced by the dispersion and spectral characteristics of the plasmonic modes. In our study, we investigated the angular behavior of the fluorescence emission from ATTO700 dye by varying the collection angle using a standard optical microscope coupled with a spectrometer. Our results show a clear dependence of fluorescence emission in terms of spectral shape on the collection angle that can be attributed to plasmonic mode dispersion.
Long noncoding RNA small nucleolar RNA host genes as prognostic molecular biomarkers in hepatocellular carcinoma: A meta‐analysis
Authors: Huang Meng , Zhao Zhiwen , Yang Lihua 
Published: April 2024

AbstractBackgroundRecently, increasing data have suggested that the lncRNA small nucleolar RNA host genes (SNHGs) were aberrantly expressed in hepatocellular carcinoma (HCC), but the association between the prognosis of HCC and their expression remained unclear. The purpose of this meta‐analysis was to determine the prognostic significance of lncRNA SNHGs in HCC.MethodsWe systematically searched Embase, Web of Science, PubMed, and Cochrane Library for eligible articles published up to February 2024. The prognostic significance of SNHGs in HCC was evaluated by hazard ratios (HRs) and 95% confidence intervals (CIs). Odds ratios (ORs) were used to assess the clinicopathological features of SNHGs.ResultsThis analysis comprised a total of 25 studies covering 2314 patients with HCC. The findings demonstrated that over‐expressed SNHGs were associated with larger tumor size, multiple tumor numbers, poor histologic grade, earlier lymphatic metastasis, vein invasion, advanced tumor stage, portal vein tumor thrombosis (PVTT), and higher alpha‐fetoprotein (AFP) level, but not with hepatitis B virus (HBV) infection, and cirrhosis. In terms of prognosis, patients with higher SNHG expression were more likely to have shorter overall survival (OS), relapse‐free survival (RFS), and disease‐free survival (DFS).ConclusionsIn conclusion, upregulation of SNHGs expression correlates with shorter OS, RFS, DFS, tumor size and numbers, histologic grade, lymphatic metastasis, vein invasion, tumor stage, PVTT, and AFP level, suggesting that SNHGs may serve as prognostic biomarkers in HCC.