bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Synthesis of Spiroisoxazoles via 1,3‐Dipolar Cycloaddition of Nitrile Oxide to 6‐Arylidene‐6,7,8,9‐tetrahydrobenzocyclohepten‐5‐one.
Authors: Venkateswarlu Peesapati , Vasireddy Nageswara Rao 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Efficient and Chemoselective Synthesis of N‐Substituted 2‐Aminopyridines via a Microwave‐Assisted Multicomponent Reaction.
Authors: Tu Shujiang , Jiang Bo , Zhang Yan , Jia Runhong , Zhang Junyong , Yao Changsheng , Shi Feng 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Continuing Efforts on the Improvement of Beckmann Rearrangement of Indanone Oxime.
Authors: Torisawa Yasuhiro , Nishi Takao , Minamikawa Jun‐ichi 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Microwave‐Assisted Synthesis of N‐(3‐Aryl‐1,8‐naphthyridin‐2‐yl)phthalimides under Solvent‐Free Conditions.
Authors: Mogilaiah K. , Sakram B. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Substituted Pyridopyrimidinones. Part 1. Convenient PTC Alkylation and Halogenation of 2‐Hydroxy‐4H‐pyrido[1,2‐a]pyrimidin‐4‐one.
Authors: Abass Mohamed , Mayas Aisha S. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of DMJ Analogues with Seven‐ and Eight‐Membered Iminocyclitols.
Authors: Chang Meng‐Yang , Kung Yung‐Hua , Ma Chih‐Chong , Chen Shui‐Tein 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Photoinduced Cytotoxicity of Prodigiosin Analogues.
Authors: Park Gyungse , Tomlinson John T. , Misenheimer Jacob A. , Kucera Gregory L. , Manderville Richard A. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Two New Terpenes from the Lichen Parmelia perlata
Authors: Abdullah S. Tarique , Hamid Hinna , Ali Mohammad , Ansari S. H. , Alam M. Sarwar 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chiral Aminoalkyl Cation Equivalents. Part 2. Novel Selenium‐Containing Non‐Natural Diamino Acids.
Authors: Caputo Romualdo , Capone Stefania , Della Greca Marina , Longobardo Luigi , Pinto Gabriella 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Convolutamydine A (I): The First Authenticated Absolute Configuration and Enantioselective Synthesis.
Authors: Cravotto Giancarlo , Giovenzana Giovanni B. , Palmisano Giovanni , Penoni Andrea , Pilati Tullio , Sisti Massimo , Stazi Federica 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Lycopodium Alkaloids from Huperzia serrata
Authors: Wang Heng‐Bin , Tan Chang‐Heng , Tan Jun‐Jie , Gao Ming‐Yao , Li Yi‐Ming , Jiang Shan‐Hao , Zhu Da‐Yuan 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A de novo Asymmetric Approach to Achiral Deoxy‐Melodorinol Analogues.
Authors: Ahmed Md. Moinuddin , Akhmedov Novruz G. , Cui Hu , Friedrich Dirk , O'Doherty George A. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of Natural 8‐ and 9‐Membered Lactones: Recent Advancements in Medium‐Sized Ring Formation
Authors: Shiina Isamu 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Carbonylation of Heterocycles by Homogeneous Catalysts.
Authors: Church Tamara L. , Getzler Yutan D. Y. L. , Byrne Christopher M. , Coates Geoffrey W. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
What Is Responsible for the Initiating Chemistry of Iron‐Mediated Lipid Peroxidation: An Update
Authors: Cheng Zhiyong , Li Yuanzong 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A prospective, multicentric scoring system to predict mortality in febrile neutropenic children with cancer
Authors: Paganini Hugo R. , Aguirre Clarisa , Puppa Gabriela , Garbini Cecilia , Javier Ruiz Guiñazuú , Ensinck Gabriela , Vrátnica Claudia , Flynn Luis , Iacono Marisa , Zubizarreta Pedro ,   for the Febrile Neutropenia Study Group
Published: May 2007

AbstractBACKGROUND.Many studies have succeeded in identifying a subset of children with febrile neutropenia (FN) who are at lower risk of infectious complications and eventual death. Conversely, to the authors' knowledge, no scoring system has been published to date with which to assess the risk of mortality for the whole group of children with neutropenia and fever.METHODS.Between March 2000 and July 2004, 1520 episodes of FN in 981 children were included in a multicentric prospective study to evaluate a scoring system that was designed to identify high mortality risk at the onset of an FN episode in children with cancer.RESULTS.In the derivation set (714 episodes), 18 patients died (2.5%). A multivariate analysis yielded the following significant mortality‐related risk factors: advanced stage of underlying malignant disease (odds ratio [OR], 3122.1; 95% confidence interval [95% CI], 0.0001–5.2), associated comorbidity (OR, 25.3; 95% CI, 7.7–83.2), and bacteremia (OR, 7.2; 95% CI, 2.4–22.0). A mortality score could be built with 3 points scored for the presence of advanced‐stage underlying malignant disease, 2 points scored for the presence of associated comorbidity, and 1 point scored for bacteremia. If patients collected 4 points of the risk score at onset, then their risk of mortality was 5.8%; if patients had a score of 5 points, then their risk of mortality was 15.4%; and, if they reached the maximum score of 6 points, then their risk of mortality was raised to 40%. The sensitivity of the scoring system was 100%, and it had a specificity of 84.2%. In the validation set (806 episodes), 19 children died (2.3%). For children with scores >3, the scoring system had a sensitivity of 84.2%, a specificity of 83.2%, and a negative predictive value of 99.54% for predicting mortality.CONCLUSIONS.The use of a mortality score for high‐risk patients was validated statistically by the current results. This is a major prognostic approach to categorize patients with high‐risk FN at onset. A better initial predictive approach may allow better therapeutic decisions for these children, with an eventual impact on reducing mortality. Cancer 2007. © 2007 American Cancer Society.
Passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer: A case‐control study
Authors: Hassan Manal M. , Abbruzzese James L. , Bondy Melissa L. , Wolff Robert A. , Vauthey Jean‐Nicolas , Pisters Peter W. , Evans Douglas B. , Khan Rabia , Lenzi Renato , Jiao Li , Li Donghui 
Published: May 2007

AbstractBACKGROUND.The associations between passive smoking and the use of noncigarette tobacco products with pancreatic cancer are not clear.METHODS.In this case‐control study, the authors collected information on passive smoking and the use of noncigarette tobacco products in 808 patients with pancreatic adenocarcinoma and 808 healthy controls by personal interview. Multivariable logistic regression was performed to estimate the adjusted odds ratio (AOR) and 95% confidence interval (95% CI).RESULTS.The results confirmed the previously reported association between active smoking and increased risk for pancreatic cancer. The AOR was 1.7 (95% CI, 1.4–2.2) for regular smokers, 1.8 (95% CI, 1.4–2.4) for long‐term smokers, and 3.1 (95% CI, 2.2–4.3) for former smokers. Although passive smoking showed a nonsignificantly elevated risk for pancreatic cancer in the entire study population (AOR, 1.3; 95% CI, 0.9–1.7), the association was present among ever smokers (AOR, 1.7; 95% CI, 1.03–2.6) but was absent among never smokers (AOR, 1.1; 95% CI, 0.8–1.6). Neither intensity nor duration of passive smoking modified the risk of pancreatic cancer among never smokers. The use of chewing tobacco, snuff, and pipes showed no significant risk elevation for pancreatic cancer after controlling for the confounding effects of demographics and other known risk factors. The use of cigars in never smokers showed a borderline significant increase of risk for pancreatic cancer (AOR, 2.2; 95% CI, 1.0–4.7; P = .05).CONCLUSIONS.The current observations did not support a role for passive smoking or the use of noncigarette tobacco products in the etiology of pancreatic cancer. The association between cigar use and the risk of pancreatic cancer needs to be confirmed in other study populations. Cancer 2007. © 2007 American Cancer Society.
Development of the caudal nerve cord, motoneurons, and muscle innervation in the appendicularian urochordate Oikopleura dioica
Authors: SØviknes Anne Mette , Chourrout Daniel , Glover Joel C. 
Published: May 2007

AbstractThe development of the caudal nerve cord and muscle innervation in the appendicularian Oikopleura dioica was assessed using differential interference contrast and confocal microscopy, phalloidin staining of actin, and in situ hybridization for the neuronal markers tubulin and choline acetyltransferase (ChAT). The caudal nerve cord first appears as a stream of tubulin mRNA‐positive neurons that extends into the tail from the caudal ganglion. By this stage a few actin‐rich nerve fibers course longitudinally along the cord. As the tail lengthens, the caudal nerve cord extends and becomes more fasciculated and the neurons cluster at stereotyped longitudinal positions. The number of neurons in the nerve cord reaches a relatively stable maximum of about 29. A subset of neurons in the caudal ganglion and caudal nerve cord expresses ChAT mRNA. These putative motoneurons are distributed along nearly the full extent of the tail in numbers consistent with an independent innervation of each tail muscle cell. The longitudinal series of putative motoneurons is not aligned with the muscle cells, but peripheral nerve fibers extending to the muscle cells are, indicating that motor axons grow along the cord before exiting adjacent to their peripheral target. Muscle innervation occurs roughly coincident with the onset of ChAT mRNA expression. Our results provide the first molecular identification of motoneurons and the first developmental characterization of the motor system in an appendicularian and help set the stage for gene expression studies aimed at understanding the evolution of developmental patterning in this part of the chordate central nervous system. J. Comp. Neurol. 503:224–243, 2007. © 2007 Wiley‐Liss, Inc.
Retinal ganglion cell dendrites undergo a visual activity‐dependent redistribution after eye opening
Authors: Xu Hong‐Ping , Tian Ning 
Published: May 2007

AbstractRecent studies showed that light stimulation is required for the maturational segregation of retinal ganglion cell (RGC) synaptic connectivity with ON and OFF bipolar cells in mammalian retina. However, it is not clear to what extent light stimulation regulates the maturation of RGC dendritic ramification and synaptic connections. The present work quantitatively analyzed the dendritic ramification patterns of different morphological subtypes of RGCs of developing mouse retinas and demonstrated that RGCs in all four major morphological subtypes underwent profound dendritic redistributions from the center to specific stratum of the IPL after eye opening. Light deprivation preferentially blocked the developmental RGC dendritic redistribution from the center to sublamina a of the IPL. Interestingly, this developmental redistribution of RGC dendrites could not be explained by a simple developmental elimination of “excess” dendrites and, therefore, suggests a possible mechanism that requires both selective dendritic growth and elimination guided by visual activity. J. Comp. Neurol. 503:244–259, 2007. © 2007 Wiley‐Liss, Inc.
Development and migration of GABAergic neurons in the mouse myelencephalon
Authors: Tashiro Yasura , Yanagawa Yuchio , Obata Kunihiko , Murakami Fujio 
Published: May 2007

AbstractGABAergic neurons are the major inhibitory interneurons that are widely distributed in the central nervous system. It is well established that they originate from a focal region in the embryonic forebrain during development, and then migrate to other regions such as the neocortex. However, the migration of GABAergic neurons remains obscure in other axial levels of the brain. We examined the early development of myelencephalic GABAergic neurons using glutamate decarboxylase 67 / green fluorescent protein (GAD67‐GFP) knockin mice. Observation of fixed tissues in coronal sections and flat whole‐mount preparations indicated that, while GFP‐positive cells are restricted to the subpial region in the ventral aspect of the myelencephalon at an early stage, they spread dorsally and eventually occupy the entire region of the myelencephalon as development proceeds. We developed a flat‐mount in vitro preparation in which these patterns of development could be recapitulated. Transplantation of dorsal myelencephalic tissue of a wildtype embryo to a corresponding region of GAD67‐GFP mouse embryos clearly demonstrated invasion of dorsally oriented GABAergic neurons from host to donor tissue. These results indicate that ventral‐to‐dorsal tangential migration of GABAergic neurons takes place in the myelencephalon. Our results extend the observations in the forebrain that inhibitory and excitatory neurons in a specific brain compartment take distinct migratory paths. J. Comp. Neurol. 503:260–269, 2007. © 2007 Wiley‐Liss, Inc.
Olfactory ensheathing cells express smooth muscle α‐actin in vitro and in vivo
Authors: Jahed Ali , Rowland James W. , McDonald Todd , Boyd J. Gordon , Doucette Ronald , Kawaja Michael D. 
Published: May 2007

AbstractOne strategy for spinal cord repair after injury that has moved quickly from the research laboratory to the clinic is the implantation of olfactory ensheathing cells (OECs). These unique glial cells of the olfactory system have been associated with axonal remyelination and regeneration after grafting into spinalized animals. Despite these promising observations, there remains a lack of direct empirical evidence of the exact fate of OECs after intraspinal implantation, in large part because of a surprising paucity of defined biomarkers that unequivocally distinguish these cells from phenotypically similar Schwann cells. Here we provide direct neurochemical proof that OECs, both in vitro and in vivo, express smooth muscle α‐actin. That OECs synthesize this contractile protein (and a variety of actin‐binding proteins including caldesmon) provides compelling evidence that these cells are, in fact, quite different from Schwann cells. The identification of several smooth muscle‐related proteins in OECs points to a new appreciation of the structural and functional features of this population of olfactory glia. These biomarkers can now be used to elucidate the fate of OECs after intraspinal implantation, in particular assessing whether smooth muscle α‐actin‐expressing OECs are capable of facilitating axon remyelination and regeneration. J. Comp. Neurol. 503:209–223, 2007. © 2007 Wiley‐Liss, Inc.
Effect of Pb on the properties of Sr2YRu1‐xCuxO6 crystals grown from PbO‐PbF2 solutions at high temperatures
Authors: Rao S. M. , Wu M. K. , Wang K. J. , Yen N. Y. , Ling M. C. , Liu H. L. , Chen C. L. 
Published: May 2007

AbstractSingle crystals of Sr2YRu1‐xCuxO6 with x=0 and x=0.1 were grown using PbO‐PbF2 based solutions at different temperatures in the range 1150–1350°C. The influence of Pb from the solutions and the Cu from the solid solutions of Sr2YRu1‐xCuxO6 on the resulting crystals was studied using microstructure and magnetic property measurements. The peaks in the powder X‐ray diffraction patterns and Raman spectra do not change in the case of x=0 crystals but shift in the presence of Cu. A diamagnetic transition indicative of superconductivity was observed in the presence of Cu and an antiferromagnetic behavior with x=0. Based on these results it is concluded that Pb may not be incorporated in the crystals and even if it does the influence is not observed. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Photoacoustic studies on the thermal properties of the NLO compound: L‐alaninium maleate
Authors: Britto Dhas S. A. Martin , Ramachandran E. , Raji P. , Ramachandran K. , Natarajan S. 
Published: May 2007

AbstractStudies on thermal and optical properties are very essential for a nonlinear optical material. Photoacoustics (PA) is a recently developed non‐destructive testing (NDT) tool for studying such properties. L‐Alaninium maleate (C3H8NO2+·C4H3O4‐), an organic non‐linear optical (NLO) material was synthesized using submerged seed solution method and was characterized by single crystal X‐ray diffraction (XRD) and density. PA technique was used to determine the thermal parameters of LAM crystals. Moreover, possible phase transition analysis was conducted to ascertain the thermal stability. Scanning electron microscopic (SEM) studies were also carried out and crystal‐packing features discussed. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
XRD, thermal and FTIR studies on gel grown DL‐Phenylalanine crystals
Authors: Ramachandran E. , Natarajan S. 
Published: May 2007

AbstractPhenylalanine [C9H11NO2] is one of the essential amino acids in humans. DL‐phenylalanine was crystallized in silica gel under suitable pH conditions by reduction of solubility method. The grown crystals were characterized by density measurement and X‐ray powder diffraction. Fourier transform infrared spectroscopy, and thermogravimetric analysis were also carried out. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
IL‐15‐induced human DC efficiently prime melanoma‐specific naive CD8+ T cells to differentiate into CTL
Authors: Dubsky Peter , Saito Hiroaki , Leogier Marylene , Dantin Carole , Connolly John E. , Banchereau Jacques , Palucka A. Karolina 
Published: May 2007

AbstractMonocytes differentiate into dendritic cells (DC) in response to GM‐CSF combined with other cytokines including IL‐4 and IL‐15. Here, we show that IL15‐DC are efficient in priming naive CD8+ T cells to differentiate into melanoma antigen‐specific cytotoxic T lymphocytes (CTL). While both melanoma peptide‐pulsed IL15‐DC and IL4‐DC expand high‐precursor frequency MART‐1‐specific CD8+ T cells after two stimulations in vitro, IL15‐DC require much lower peptide concentration for priming. IL15‐DC are more efficient in expanding gp100‐specific CD8+ T cells and can expand CD8+ T cells specific for Tyrosinase and MAGE‐3. CTL primed by IL15‐DC are superior in their function as demonstrated by (i) higher IFN‐γ secretion, (ii) higher expression of Granzyme B and Perforin, and (iii) higher killing of allogeneic melanoma cell lines, most particularly the HLA‐A*0201+ Sk‐Mel‐24 melanoma cells that are resistant to killing by CD8+ T cells primed with IL4‐DC. Supernatants of the sonicated cells demonstrate unique expression of IL‐1, IL‐8 and IL‐15. Therefore, membrane‐bound IL‐15 might contribute to enhanced priming by IL15‐DC. Thus, IL‐15 induces myeloid DC that are efficient in priming and maturation of melanoma antigen‐specific CTL.
Pyridine Carboxylate Complexes of MoII as Active Catalysts in Homogeneous and Heterogeneous Polymerization
Authors: Vasconcellos‐Dias Maria , Nunes Carla D. , Vaz Pedro D. , Ferreira Paula , Calhorda Maria José 
Published: May 2007

AbstractNew lamellar materials intercalated with molybdenum(II) complexes with potential catalytic properties were prepared by a stepwise procedure. The lamellar material was first calcined at 823 K for four hours to eliminate all the carbonate ions; the layered structure was reconstructed after treatment with a solution of either pycH (pyridine‐2‐carboxylic acid) or pydcH2 (pyridine‐2,6‐dicarboxylic acid) in a KOH solution of dmf at 343 K. Impregnation with a solution of the organometallic precursor [Mo(CO)3I2(NCCH3)2] led to substitution of the nitrile groups by two pyridine ligands. All the materials were characterized by powder X‐ray diffraction, FTIR, and 13C CP MAS and 27Al MAS solid‐state NMR spectroscopy. Similar MoII complexes were also prepared by using pycH or pydcH2 and characterized by elemental analysis as well as FTIR and 1H and 13C solution NMR spectroscopy. These new materials and the complexes of pyc or pydc ligands containing 4.54 wt.‐% and 6.33 wt.‐% of Mo respectively, catalyze the ring‐opening‐metathesis polymerization of norbornene and the polymerization of styrene at 333 K, their performance increasing upon the addition of methylalumoxane (MAO) as cocatalyst.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
[2.2.2]Propellane Isomerization by Grob Rearrangement: An Ab Initio MR‐AQCC Study
Authors: Antol Ivana , Eckert‐Maksić Mirjana , Lischka Hans , Maksić Zvonimir B. 
Published: May 2007

AbstractThe multireference average quadratic couple cluster (MR‐AQCC) method has been employed to explore isomerism in the [2.2.2]propellane 1 as well as the accompanying Grob‐type fragmentation. It is shown that the open form 2 is more stable than the conventional closed propellane 1 by 3.6 kcal mol–1. These two isomers are separated by a barrier as high as 22.7 kcal mol–1, taking 1 as a reactant, a value that is in excellent agreement with experiment. However, system 2 is not a stable species because it is located in a very shallow energy minimum. Consequently, it undergoes almost barrierless cage‐opening to the thermodynamically most stable 1,4‐dimethylenecyclohexane (3). The singlet–triplet gap along the bond‐stretch reaction coordinate has been calculated too. It is shown that intersystem crossing can be expected in the vicinity of the saddle point. It is concluded that photochemical closure of the bridgehead C–C bond yielding 1 has a lower probability than geometry relaxation leading to structure 2 and ultimately to the stable compound 3. The structural features of the elusive systems 1 and 2 are discussed in some detail. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)