bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase II Trial of Idiotype Vaccination in Previously Treated Patients With Indolent Non-Hodgkin’s Lymphoma Resulting in Durable Clinical Responses
Authors: Redfern Charles H. , Guthrie Troy H. , Bessudo Alberto , Densmore John J. , Holman Peter R. , Janakiraman Nalini , Leonard John P. , Levy Richard L. , Just Richard G. , Smith Mitchell R. , Rosenfelt Fred P. , Wiernik Peter H. , Carter William D. , Gold Daniel P. , Melink Teresa J. , Gutheil John C. , Bender John F. 
Published: June 2006

Purpose To evaluate idiotype (Id) vaccination as a single agent in previously treated patients with indolent non-Hodgkin’s lymphoma. Patients and Methods Patients underwent biopsy for determination of their lymphoma-specific Id sequence. Recombinant Id protein was manufactured and covalently linked with keyhole limpet hemocyanin (KLH) to generate Id/KLH. Patients received Id/KLH 1 mg on day 1 subcutaneously, with granulocyte-macrophage colony-stimulating factor 250 μg on days 1 to 4, monthly for 6 months. Booster injections were administered until progression. Both clinical and immune responses were evaluated. Results Thirty-two previously treated patients received at least one injection of Id/KLH, and 31 were assessed for efficacy. Responses were observed in four patients (one complete response and three partial responses). Median time to onset of response was 5.9 months (range, 2.3 to 14.1 months). Median duration of response has not been reached but should be at least 19.4 months (range, 10.4 to 27.2+ months). Median time to progression is 13.5 months. The most common adverse events were mild to moderate injection site reactions. Six (67%) of nine patients tested demonstrated a cellular immune response, and four (20%) of 20 patients demonstrated an antibody response against their Id. Conclusion This trial demonstrates that Id/KLH alone can induce tumor regression and durable objective responses. Further study of Id/KLH is recommended in other settings where efficacy may be further enhanced as in first-line therapy or after cytoreductive therapy.
Frequency, Characteristics, and Reversibility of Peripheral Neuropathy During Treatment of Advanced Multiple Myeloma With Bortezomib
Authors: Richardson Paul G. , Briemberg Hannah , Jagannath Sundar , Wen Patrick Y. , Barlogie Bart , Berenson James , Singhal Seema , Siegel David S. , Irwin David , Schuster Michael , Srkalovic Gordan , Alexanian Raymond , Rajkumar S. Vincent , Limentani Steven , Alsina Melissa , Orlowski Robert Z. , Najarian Kevin , Esseltine Dixie , Anderson Kenneth C. , Amato Anthony A. 
Published: June 2006

Purpose To determine the frequency, characteristics, and reversibility of peripheral neuropathy from bortezomib treatment of advanced multiple myeloma. Patients and Methods Peripheral neuropathy was assessed in two phase II studies in 256 patients with relapsed and/or refractory myeloma treated with bortezomib 1.0 or 1.3 mg/m2 intravenous bolus on days 1, 4, 8, and 11, every 21 days, for up to eight cycles. Peripheral neuropathy was evaluated at baseline, during the study, and after the study by patient-reported symptoms using the Functional Assessment of Cancer Therapy Scale/Gynecologic Oncology Group–Neurotoxicity (FACT/GOG-Ntx) questionnaire and neurologic examination. During the study, peripheral neuropathy was also evaluated by investigator assessment. A subset of patients underwent nerve conduction studies (n = 13). Results Before treatment, 194 (81%) of 239 patients had peripheral neuropathy by FACT/GOG-Ntx questionnaire, and 203 (83%) of 244 patients had peripheral neuropathy by neurologic examination. Treatment-emergent neuropathy was reported in 35% of patients, including 37% (84 of 228 patients) receiving bortezomib 1.3 mg/m2 and 21% (six of 28 patients) receiving bortezomib 1.0 mg/m2. Grade 1 or 2, 3, and 4 neuropathy occurred in 22%, 13%, and 0.4% of patients, respectively. The incidence of grade ≥ 3 neuropathy was higher among patients with baseline neuropathy by FACT/GOG-Ntx questionnaire compared with patients without baseline neuropathy (14% v 4%, respectively). In all 256 patients, neuropathy led to dose reduction in 12% and discontinuation in 5%. Of 35 patients with neuropathy ≥ grade 3 and/or requiring discontinuation, resolution to baseline or improvement occurred in 71%. Conclusion Bortezomib-associated peripheral neuropathy seemed reversible in the majority of patients after dose reduction or discontinuation. Although severe neuropathy was more frequent in the presence of baseline neuropathy, the overall occurrence was independent of baseline neuropathy or type of prior therapy.
Combined-Modality Therapy for Clinical Stage I or II Hodgkin's Lymphoma: Long-Term Results of the European Organisation for Research and Treatment of Cancer H7 Randomized Controlled Trials
Authors: Noordijk Evert M. , Carde Patrice , Dupouy Noëlle , Hagenbeek Anton , Krol Augustinus D.G. , Kluin-Nelemans Johanna C. , Tirelli Umberto , Monconduit Mathieu , Thomas José , Eghbali Houchingue , Aleman Berthe M.P. , Bosq Jacques , Vovk Marjeta , Verschueren Tom A.M. , Pény Anne-Marie , Girinsky Théodore , Raemaekers John M.M. , Henry-Amar Michel 
Published: June 2006

Purpose In early-stage Hodgkin's lymphoma (HL), subtotal nodal irradiation (STNI) and combined chemotherapy/radiotherapy produce high disease control rates but also considerable late toxicity. The aim of this study was to reduce this toxicity using a combination of low-intensity chemotherapy and involved-field radiotherapy (IF-RT) without jeopardizing disease control. Patients and Methods Patients with stage I or II HL were stratified into two groups, favorable and unfavorable, based on the following four prognostic factors: age, symptoms, number of involved areas, and mediastinal-thoracic ratio. The experimental therapy consisted of six cycles of epirubicin, bleomycin, vinblastine, and prednisone (EBVP) followed by IF-RT. It was randomly compared, in favorable patients, to STNI and, in unfavorable patients, to six cycles of mechlorethamine, vincristine, procarbazine, prednisone, doxorubicin, bleomycin, and vinblastine (MOPP/ABV hybrid) and IF-RT. Results Median follow-up time of the 722 patients included was 9 years. In 333 favorable patients, the 10-year event-free survival rates (EFS) were 88% in the EBVP arm and 78% in the STNI arm (P = .0113), with similar 10-year overall survival (OS) rates (92% v 92%, respectively; P = .79). In 389 unfavorable patients, the 10-year EFS rate was 88% in the MOPP/ABV arm compared with 68% in the EBVP arm (P < .001), leading to 10-year OS rates of 87% and 79%, respectively (P = .0175). Conclusion A treatment strategy for early-stage HL based on prognostic factors leads to high OS rates in both favorable and unfavorable patients. In favorable patients, the combination of EBVP and IF-RT can replace STNI as standard treatment. In unfavorable patients, EBVP is significantly less efficient than MOPP/ABV.
Mechanism of Water Attacking on Brooker’s Merocyanine Dye and Its Effect on the Molecular and Electronic Structures: Theoretical Study
Authors: Awad Mohamed K , Abdel-Halim Shakir T 
Published: June 2006

Abstract
Semiempirical molecular orbital calculations have been performed to study the mechanism by which water molecules attack the highly negative oxycyclic oxygen atom of Brooker’s merocyanine 1-methyl-4-(4′-oxidostyryl)pyridinium betaine, M, to form mono-, di-, and tri-hydrated merocyanine complexes. In the case of mono- and di-hydrated complexes, one or two water molecules attack the oxygen atom, respectively, but in the case of the tri-hydrated complex, only two water molecules attack the oxygen atom of M with sp2 hybridization, while the third one forms a H-bond with either one of the oxygen atoms of the coordinated water molecules. The effect of H-bond formation on the molecular and electronic structures of merocyanine is investigated using the atom superposition and electron delocalization molecular orbital (ASED-MO) theory. The calculations show that the hydrated complexes are shifted towards the benzenoid valence structures in the ground state, but shifted towards quinonoid ones upon excitation. On the basis of the calculated charge distribution over the whole skeleton of the complexes, it is found that the dipole moments of the complexes are slightly affected by H-bond formation in the ground state, but strongly decrease upon excitation. The formation of hydrated merocyanine complexes are highly exothermic, downhill reactions, which is explained with respect to the stabilization of the HOMO and oxygen lone-pair levels. We believe that the attacking by water with acidic character on the basic site oxygen atom of merocyanine is a kind of acid–base interaction.
Synthesis and Characterization of Polydentate Schiff-Base Ligands and Their Complexes
Authors: Demirelli Havva , Tümer Mehmet , Gölcü Aysegül 
Published: June 2006

Abstract
In this study, we synthesized the amine compounds 2-{(E)-[(2-aminoethyl)imino]methyl}phenol (H3A) and 2-{(E)-[(3-aminopropyl)imino]methyl}-6-methoxyphenol (H3B) as the starting materials. From reactions of the starting materials with 2-hydroxy-5-methylisophthalaldehyde, phthalaldehyde, and 2-hydroxy-5-t-butylisophthalaldehyde, we prepared the new ligands H3L1–H3L3 and H2L. The Cu(II) and Cd(II) complexes of the ligands have been obtained. Microanalytical data, magnetic moment, 1H(13C) NMR, mass spectra, FT-IR, and conductivity measurements have been used to explain the structures of the ligands and their complexes. The protonation constants of the ligands H3L1–H3L3 have been studied in a 1:1 molar ratio (M:L). Protonation and stability constants of the Schiff bases and their Cu(II) and Cd(II) complexes have been determined by the potentiometric titration method in 50% dioxane–water media at 25.00 ± 0.02 °C under a nitrogen atmosphere and ionic strength of 0.1 M NaClO4. The ligands H3L1–H3L3 have seven protonation constants. In other words, the ligand H2L has six protonation constants. The variation of protonation constants of these compounds were interpreted on the basis of structural effects exposed by the substituents.
197Au Mössbauer Spectroscopic Study of Binuclear Cycloaurated Complexes Containing Bridging (2-Diphenylarsino-n-methyl)phenyl (n = 5 and 6)
Authors: Kitadai Kunihiko , Takahashi Masashi , Takeda Masuo , Bhargava Suresh K , Bennett Martin A 
Published: June 2006

Abstract
197Au Mössbauer spectra have been measured on a series of binuclear gold complexes containing a bridging As–C ligand. The plot of quadrupole splitting (Q.S.) against isomer shift (I.S.) indicates that the gold–arsenic bond in these complexes is less covalent than the gold–phosphorus bond in analogous P–C complexes.
Synthesis and Spectral Properties of Fluorescent Dithienylmaleimides
Authors: Shirinian Valerii Z , Krayushkin Mikhail M , Nabatov Boris V , Kuznetsova Ol’ga Yu , Shimkin Alexey A 
Published: June 2006

Abstract
A convenient preparative method of the synthesis of dithienylethenes based on maleimides was proposed. Previously, difficult accessible dithienylethene derivatives, in which 2-thienyl substituents are attached to the double bond of maleimide, have been synthesized. The spectral properties of the dithienylmaleimides were studied and it has been shown that these compounds do not belong to photochromes but they possess fluorescent properties.
Phenalenyl-Based Highly Conductive Molecular Systems with Hydrogen-Bonded Networks: Synthesis, Physical Properties, and Crystal Structures of 1,3- and 1,6-Diazaphenalenes, and Their Protonated Salts and Charge-Transfer Complexes with TCNQ
Authors: Murata Tsuyoshi , Morita Yasushi , Fukui Kozo , Tamaki Koichi , Yamochi Hideki , Saito Gunzi , Nakasuji Kazuhiro 
Published: June 2006

Abstract
Protonated salts and charge-transfer complexes of the 1,3- and 1,6-diazaphenalene (DAP) systems 5–7 have been investigated for new conducting molecule-based materials. Cyclic voltammetry measurements revealed that DAP derivatives are stronger electron donors than hydroquinone, and some of them possess comparable electron-donating abilities to TTF. X-ray crystal structure analyses of HX (X = Br− and BF4−) salts of 5b, 5c, and 6e confirmed their one-dimensional structures by N–H···X···H–N hydrogen bonds and their ability to form hydrogen-bonded networks in charge-transfer complexes. Actually, in the TCNQ salts of protonated 5c·H+ and 7b·H+, N–H···N≡C hydrogen-bonding interactions between DAP molecules and TCNQ molecules constructed a characteristic hydrogen-bonded cyclic tetramer and linear D–A–D triad, respectively. On the other hand, TCNQ complexes of 1,3- and 1,6-DAP derivatives, prepared by a conventional mixing method of each neutral component, were found to be partial charge-transfer complexes with segregated stacking columns as elucidated from IR and electronic spectra. Their compressed pellets exhibited high electrical conductivity (10−2–10−1 S cm−1) at room temperature with semiconducting behavior (activation energy, Ea = 40–80 meV).
Structure Elucidation of Briarane Diterpenoids Using Molecular Mechanics Calculations
Authors: Uchio Yasuto , Kubota Natsuki K , Haino Takeharu , Fukazawa Yoshimasa 
Published: June 2006

Abstract
A combination of NMR analysis and molecular mechanics calculations has succeeded in the determination of the stereostructure of flexible briarane diterpenoids. The molecular mechanics calculations disclosed the multi-conformational nature of the briarane diterpenoids and gave a successful reproduction of the observed 3J coupling constants to give the correct relative configuration of each stereogenic center in these molecules. An X-ray crystallographic study of these diterpenoids supports the reliable performance of the structure elucidation of these compounds.
Total Synthesis of Stevastelins: Structure Confirmation of Stevastelins B and B3, and Structure Revision of Stevastelin C3
Authors: Kurosawa Kazuo , Matsuura Keigo , Nagase Toshihiko , Chida Noritaka 
Published: June 2006

Abstract
The total syntheses of stevastelins B, B3, C3, and the 5-deoxy derivative of stevastelin C3, novel cyclic depsipeptides starting from l-quebrachitol, and amino acids are described. Stereoselective introduction of two methyl groups into l-quebrachitol, followed by regioselective cleavage of the cyclohexane ring by way of the Baeyer–Villiger reaction effectively afforded the fatty acid moiety of stevastelins. Introduction of the peptide and subsequent macrolactamization gave stevastelin B. Stevastelins C3 and B3 were also synthesized by a similar way. The direct comparison of synthetic stevastelins with natural compounds revealed that the synthetic stevastelins B and B3 are identical to the natural products, confirming the proposed structures. However, the synthetic stevastelin C3 was found to not be identical with the natural product. To elucidate the structure of stevastelin C3, degradation of the natural product was carried out to show the possibility that the natural product could be a 5-deoxy derivative of the proposed structure. Thus, the 5-deoxy derivative of the fatty acid moiety was prepared and transformed into a macrocycle. The synthetic 5-deoxy compound was fully identical to natural stevastelin C3. Based on these studies, it was shown that the structure of stevastelin C3 should be revised.
Effect of Water Molecules on the Cycloaromatization of Non-Conjugated Aromatic Tetraynes
Authors: Kawano Tomikazu , Inai Hiroki , Miyawaki Kazuhiro , Ueda Ikuo 
Published: June 2006

Abstract
Cycloaromatization of the thienyl tetrayne 1, which was prepared in several steps from bis(trimethylsilyl)butadiyne and 3-bromothiophene-2-carbaldehyde, in benzene (0.33 mM) in the presence of molecular sieves 3A at room temperature gave the indeno[2,1-b]thiophene ring-fused 1H-2-benzopyran derivative 10 and indeno[2,1-b]thiophene derivative 11 in 11 and 40% yields, respectively. In contrast, cycloaromatization of 1 in the presence of water molecules at room temperature gave the indeno[2,1-b]thiophene ring-fused 1H-2-benzopyran derivative 10 and the indene ring-fused indeno[2,1-b]thiophene derivative 12 in 82 and 14% yields, respectively. Cycloaromatization of the phenyl tetrayne 9 in the presence of water molecules at room temperature also resulted in a dramatic change in product yields.
N,N-Bis(4-{5-[N,N-bis(4-methoxyphenyl)-N-yloammonio]-2-methylstyryl}phenyl)ammoniumyl Triradical: A Trimer Model of High-Spin Poly[(4-methoxyphenyl-N-yloammonio)-1,2(or 4)-phenylenevinylene-1,2(or 4)-phenylene]
Authors: Fukuzaki Eiji , Abe Shigemoto , Nishide Hiroyuki 
Published: June 2006

Abstract
Hyperbranched poly[(4-methoxyphenyl-N-yloammonio)-1,2(or 4)-phenylenevinylene-1,2(or 4)-phenylene], obtained by the polycondensation of N-(4-methoxyphenyl)-N-(4-vinylphenyl)-3-bromo-4-vinylaniline and the subsequent oxidation, three-directionally satisfied the non-Kekulé-type π-conjugation and ferromagnetic connectivity of the unpaired electrons of triarylammoniumyl cationic radicals, and behaved as a high-spin organic polymer even at room temperature. The trimer model compound, N-(4-{5-[N,N-bis(4-methoxyphenyl)amino]-2-methylstyryl}-3-methylphenyl)-N-(4-{5-[N,N-bis(4-methoxyphenyl)amino]-2-methylstyryl}phenyl)-4-methoxyaniline, was synthesized from N-(4-methoxyphenyl)-N-(4-vinylphenyl)-3-methyl-4-vinylaniline. The corresponding ammoniumyl triradical displayed an average S (spin quantum number) value of 3/2, which supported the strong spin-coupling between the unpaired electrons of the ammoniumyl radicals through the π-conjugated and branched phenylenevinylene structure. Head-to-tail linkage and the branched structure of the polymer were also studied by a model reaction of N-(4-methoxyphenyl)-N-(4-vinylphenyl)-3-methyl-4-vinylaniline and bromobenzene.
Generalized Alexandroff Duplicates and CD
0(K) spaces
Authors: Çaglar Mert , Ercan Zafer , Polat Faruk 
Published: June 2006

Abstract
We define and investigateCD
Σ,Γ(K, E)-type spaces, which generalizeCD
0-type Banach lattices introduced in [1]. We state that the space CD
Σ,Γ(K, E) can be represented as the space of E-valued continuous functions on the generalized Alexandroff Duplicate of K. As a corollary we obtain the main result of [6, 8].
Rate-equation calculations of the current flow through two-site molecular device and DNA-based junction
Authors: Walczak Kamil 
Published: June 2006

Abstract
Here we present the calculations of incoherent current flowing through the two-site molecular device as well as the DNA-based junction within the rate-equation approach. Selected phenomena of interest are discussed in detail. The structural asymmetry of a two-site molecule results in a rectification effect, which can be neutralized by an asymmetric voltage drop at the molecule-metal contacts due to coupling asymmetry. The results received for the poly(dG)-poly(dC) DNA molecule reveal the coupling-and temperature-independent saturation effect of the current at high voltages, establishing for short chains the inverse square distance dependence. Additionally we document the conductance peak shifting in the direction of higher voltages due to a temperature decrease.
Modulating expression of LAMPs and ABH histo-blood group antigens in normal and neoplastic human skin
Authors: Sarafian Victoria , Dikov Dorian , Karaivanov Milen 
Published: June 2006

Abstract
Although the precise biological role of lysosomal membrane-associated glycoproteins (LAMPs) and ABH histo-blood group antigens (HBGAs) remains somewhat unclear, they are thought to be related to cell differentiation, cellular adhesion, and tumorigenesis. Here, we present the first comparative immunohistochemical study of both LAMPs and HBGAs in normal and neoplastic skin. Their localization is compared to that of high molecular weight cytokeratin and cytokeratin MNF 116. LAMPs and HBGA were differentially expressed in the normal stratified squamous epithelium, suggesting that they are involved in the initial steps of the differentiation process, whereas HBGAs are characteristic of terminal keratinocyte differentiation. No change in the reactivity for HBGA was detected in the stratified epithelium overlying squamous cell or basal cell carcinomas, whereas a considerable loss of LAMPs was detected. LAMPs were overexpressed in tumor cells, whereas HBGAs were lost in tumor zones of basocellular carcinomas. In spinocellular carcinomas, HBGAs were detected in tumor keratinocytes and in keratin pearls. These results provide new evidence for the differential expression of LAMPs and HBGAs in the normal stratified squamous epithelium, as well as the presence of a modulating reactivity in basocellular and spinocellular carcinomas, suggesting that these glycoproteins are involved in differentiation and tumorigenesis of human skin.
Web issue analysis: An integrated water resource management case study
Authors: Thelwall Mike , Vann Katie , Fairclough Ruth 
Published: June 2006

AbstractIn this article Web issue analysis is introduced as a new technique to investigate an issue as reflected on the Web. The issue chosen, integrated water resource management (IWRM), is a United Nations–initiated paradigm for managing water resources in an international context, particularly in developing nations. As with many international governmental initiatives, there is a considerable body of online information about it: 41,381 hypertext markup language (HTML) pages and 28,735 PDF documents mentioning the issue were downloaded. A page uniform resource locator (URL) and link analysis revealed the international and sectoral spread of IWRM. A noun and noun phrase occurrence analysis was used to identify the issues most commonly discussed, revealing some unexpected topics such as private sector and economic growth. Although the complexity of the methods required to produce meaningful statistics from the data is disadvantageous to easy interpretation, it was still possible to produce data that could be subject to a reasonably intuitive interpretation. Hence Web issue analysis is claimed to be a useful new technique for information science.