bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of Sharp Device–Related Blood and Body Fluid Exposure in Operating Rooms
Authors: Myers Douglas J. , Epling Carol , Dement John , Hunt Debra 
Published: November 2008

Objective.The risk of percutaneous blood and body fluid (BBF) exposures in operating rooms was analyzed with regard to various properties of surgical procedures.Design.Retrospective cohort study.Setting.A single university hospital.Methods.All surgical procedures performed during the period 2001–2002 (n = 60,583) were included in the analysis. Administrative data were linked to allow examination of 389 BBF exposures. Stratified exposure rates were calculated; Poisson regression was used to analyze risk factors. Risk of percutaneous BBF exposure was examined separately for events involving suture needles and events involving other device types.Results.Operating room personnel reported 6.4 BBF exposures per 1,000 surgical procedures (2.6 exposures per 1,000 surgical hours). Exposure rates increased with an increase in estimated blood loss (17.5 exposures per 1,000 procedures with 501–1,000 cc blood loss and 22.5 exposures per 1,000 procedures with >1,000 cc blood loss), increased number of personnel ever working in the surgical field (20.5 exposures per 1,000 procedures with 15 or more personnel ever in the field), and increased surgical procedure duration (13.7 exposures per 1,000 procedures that lasted 4–6 hours, 24.0 exposures per 1,000 procedures that lasted 6 hours or more). Associations were generally stronger for suture needle–related exposures.Conclusions.Our results support the need for prevention programs that are targeted to mitigate the risks for BBF exposure posed by high blood loss during surgery (eg, use of blunt suture needles and a neutral zone for passing surgical equipment) and prolonged duration of surgery (eg, double gloving to defend against the risk of glove perforation associated with long surgery). Further investigation is needed to understand the risks posed by lengthy surgical procedures.
Effect of different conditioning treatments on total phenolic content and antioxidant activities in two Sargassacean species: Comparison of the frondose Sargassum muticum (Yendo) Fensholt and the cylindrical Bifurcaria bifurcata R. Ross
Authors: Le Lann Klervi , Jégou Camille , Stiger‐Pouvreau Valérie 
Published: November 2008

SUMMARYThe effects of different conditioning treatments (fresh, freezing, freeze‐drying, oven‐drying and greenhouse‐drying) on the total phenolic content (TPC) and antioxidant activities of two brown algae, Sargassum muticum and Bifurcaria bifurcata, were investigated and compared. Phenolic compounds were extracted in a methanol/water (50:50) solution, and TPC was measured by the colorimetric Folin‐Ciocalteu assay. Antioxidant activity was assessed by the DPPH (2, 2‐diphenyl‐1‐picrylhydrazyl) radical scavenging assay and the β‐carotene bleaching method. The dried seaweeds showed lower phenolic contents and lower antioxidant capacities than the fresh and frozen ones, which suggests that the phenolic content and antioxidant activities are decreased by the drying treatments, especially, oven‐ and greenhouse‐drying. Relationships between TPC, antioxidant properties and conditioning treatments are discussed.
Responses of vegetative gametophytes of Undaria pinnatifida to high irradiance in the process of gametogenesis
Authors: Pang Shao Jun , Shan Ti Feng , Zhang Zhi Huai 
Published: November 2008

SUMMARYThe population of Undaria pinnatifida in its ecologic niche sustains itself in high temperature summer in the form of vegetative gametophytes, the haploid stage in its heteromorphic life cycle. Gametogenesis initiates when seawater temperature drops below the threshold levels in autumn in the northern hemisphere. Given that the temperature may fall into the appropriate range for gametogenesis, the level of irradiance determines the final destiny of a gametophytic cell, either undergoing vegetative cell division or initiating gametogenesis. In elucidating how vegetatively propagated gametophytes cope with changes of irradiance in gametogenesis, we carried out a series of culture experiments and found that a direct exposure to irradiance as high as 270 μmol photons m−2 s−1 was lethal to dim‐light (7–10 μmol photons m−2 s−1) adapted male and female gametophytes. This lethal effect was linearly corelated with the exposure time. However, dim‐light adapted vegetative gametophytes were shown to be able tolerate as high as 420 μmol photons m−2 s−1 if the irradiance was steadily increased from dim light levels (7–10 μmol photons m−2 s−1) to 90, 180 and finally 420 μmol photons m−2 s−1, respectively, at a minimum of 1–3 h intervals. Percentage of female gametophytic cells that turned into oogonia and were eventually fertilized was significantly higher if cultured at higher but not lethal irradiances. Findings of this investigation help to understand the dynamic changes of population size of sporophytic plants under different light climates at different site‐specific ecologic niches. It may help to establish specific technical details of manipulation of light during mass production of seedlings by use of vegetatively propagated gametophytes.
Comptes rendus
Authors: Collinder Björn , Malmberg Bertil 
Published: November 2008

G. Réész, Ursprung und Vorgeschichte der Sprache. Bern 1946 (A. Francke AG.). 279 Seiten in Gross‐8°Edgar H. Sturtevant, An Introduction to Linguistic Science. New Haven, Yale UniversityL. Grootaers, Tweetaligheid [= Bilinguisme] (tirage à part de Album Prof. Dr Frccnk BaurR. H. Stetson, Bases of Phonology, Oberlin, Ohio
THE CAREFUL AND CASUAL SPEECH OF FACTORY WORKERS1
Authors: Tway Patricia 
Published: November 2008

SummaryThis article is concerned with the speech styles used by factory workers. It is part of a larger exploratory and descriptive study of occupational jargon. Samples of the careful and casual speech of 151 workers from all occupational levels in the factory are presented. A comparison is made between the two speech styles of the workers in order to determine which linguistic forms change, in what ways and under what conditions they change and who changes them.
Protective effects of astaxanthin on 6‐hydroxydopamine‐induced apoptosis in human neuroblastoma SH‐SY5Y cells
Authors: Ikeda Yasutaka , Tsuji Shinji , Satoh Akira , Ishikura Masaharu , Shirasawa Takuji , Shimizu Takahiko 
Published: November 2008

AbstractParkinson’s disease (PD) is a neurodegenerative disorder characterized by selective loss of dopaminergic neurons in the substantia nigra pars compacta. Although understanding of the pathogenesis of PD remains incomplete, increasing evidence from human and animal studies has suggested that oxidative stress is an important mediator in its pathogenesis. Astaxanthin (Asx), a potent antioxidant, has been thought to provide health benefits by decreasing the risk of oxidative stress‐related diseases. This study examined the protective effects of Asx on 6‐hydroxydopamine (6‐OHDA)‐induced apoptosis in the human neuroblastoma cell line SH‐SY5Y. Pre‐treatment of SH‐SY5Y cells with Asx suppressed 6‐OHDA‐induced apoptosis in a dose‐dependent manner. In addition, Asx strikingly inhibited 6‐OHDA‐induced mitochondrial dysfunctions, including lowered membrane potential and the cleavage of caspase 9, caspase 3, and poly(ADP‐ribose) polymerase. In western blot analysis, 6‐OHDA activated p38 MAPK, c‐junNH2‐terminal kinase 1/2, and extracellular signal‐regulated kinase 1/2, while Asx blocked the phosphorylation of p38 MAPK but not c‐junNH2‐terminal kinase 1/2 and extracellular signal‐regulated kinase 1/2. Pharmacological approaches showed that the activation of p38 MAPK has a critical role in 6‐OHDA‐induced mitochondrial dysfunctions and apoptosis. Furthermore, Asx markedly abolished 6‐OHDA‐induced reactive oxygen species generation, which resulted in the blockade of p38 MAPK activation and apoptosis induced by 6‐OHDA treatment. Taken together, the present results indicated that the protective effects of Asx on apoptosis in SH‐SY5Y cells may be, at least in part, attributable to the its potent antioxidative ability.
Racial Authenticity in Rap Music and Hip Hop
Authors: Harrison Anthony Kwame 
Published: November 2008

AbstractThis article reviews the history of scholarship on racial authenticity within studies of rap music and hip hop. The concept of authenticity currently enjoys a central place in sociological work on popular music, subcultures, and racial identity. As a music and cultural form that straddles all three of these fields, the debates surrounding authenticity within rap and hip hop are as contentious as any. Using the year 2000 as an arbitrary dividing line, this article presents the late 20th century foundations of research on authenticity and race within hip hop, then moves on to discuss more recent developments in the academic literature. Despite hip hop scholars’ increased emphases on discourses of space and place, and processes of culture and identity formation, the field continues to be framed through notions of essential blackness, and critical interrogations of white hip hop legitimacy. After providing an overview of the state of the field, it is argued that greater attention to language use among hip hop enthusiasts, and a particular emphasis on hip hoppers who fall outside the black–white racial binary will prove fruitful in reinvigorating these longstanding debates. Ethnographic studies of local underground hip hop scenes within the Unites States are recommended as a logical place to begin.
Evaluation of vitreous levels of gatifloxacin after systemic administration in inflamed and non‐inflamed eyes
Authors: Rajpal  , Srinivas Ambatipudi , Azad Raj Vardhan , Sharma Yog Raj , Kumar Atul , Satpathy Gita , Velpandian Thirumurthy 
Published: November 2008

Abstract.Purpose:  This study aimed to evaluate the human vitreous penetration of gatifloxacin in inflamed and non‐inflamed eyes after oral administration.Methods:  Vitreous penetration of single‐dose (400 mg) oral gatifloxacin was evaluated in patients (n = 33) undergoing vitreous tap during the standard procedure for intravitreal antibiotic injection for acute postoperative endophthalmitis at various time‐points. Vitreous penetration of 400 mg oral gatifloxacin was evaluated in the non‐inflamed eyes of patients (n = 33) undergoing pars plana vitrectomy at similar time‐points. The study was extended to evaluate the vitreous penetration of single‐dose oral (800 mg) gatifloxacin at a single time‐point in inflamed (n = 10) and non‐inflamed (n = 11) eyes.Results:  After 400 mg oral gatifloxacin, inflamed eyes showed mean vitreous concentrations of 0.58±0.19μg/ml, 1.33±0.33 μg/ml and 1.30 ± 0.23 μg/ml at 2, 4 and 6 hours, respectively. The levels reached at 2 and 4 hours were found to be significantly increased compared with those in non‐inflamed eyes. At the 800‐mg dose, 4‐hour vitreous levels in inflamed and non‐inflamed eyes were 1.57 ± 0.3 μg/ml and 1.42 ± 0.24 μg/ml, respectively. Although the increased dose of gatifloxacin elevated plasma concentration, it failed to raise vitreous levels significantly higher than the 400‐mg dose at the 4‐hour time‐point.Conclusions:  Orally administered gatifloxacin achieves therapeutic levels in both inflamed and non‐inflamed human eyes with a spectrum covering the bacterial species most frequently involved in the various causes of endophthalmitis. However, the levels achieved were below the MIC90 for Pseudomonas aureginosa and Enterococcus.
Mitigating effect of chloride ions on sulfate attack of cement mortars with or without silica fume
Authors: Lee Seung-Tae , Park Dae-Wook , Ann Ki-Yong 
Published: November 2008

This paper presents a detailed experimental study on the sulfate attack of mortar specimens with or without silica fume exposed to sulfate and sulfate–chloride solutions (with the same concentration of SO42– ions) up to 510 d. The overall aim of the study is to investigate the beneficial effect of chloride ions on sulfate attack. In addition, the role of silica fume and water–binder ratio (w/b) in resisting sulfate attack is also reported. To qualitatively assess the performance of mortar specimens exposed to test solutions, visual examination and compressive strength and expansion tests were carried out. X-ray diffraction (XRD) and mercury intrusion porosimetry (MIP) techniques were also used to evaluate the products formed by hydration and chemical reaction and the change of porosity for paste samples. Results indicated that the presence of chloride ions in sulfate environments mitigated the deterioration of ordinary Portland cement mortar specimens, especially with a higher w/b, due to sulfate attack. It seems that the mitigating effect of chloride ions on sulfate attack is attributable to the increased solubility of sulfate products in the chloride-bearing sulfate solution, and the chemical binding of the ions to form Friedel’s salt.
Streptococci and lactococci synthesize large amounts of HPr(Ser-P)(His~P)
Authors: Roy Denis J. , Casabon Israël , Vaillancourt Katy , Huot Jonathan L. , Vadeboncoeur Christian 
Published: November 2008

HPr is a protein of the phosphoenolpyruvate:sugar phosphotransferase transport system (PTS). In gram-positive bacteria, HPr can be phosphorylated on Ser-46 by the kinase/phosphorylase HprK/P and on His-15 by phospho-enzyme I (EI~P) of the PTS. In vitro studies with purified HPrs from Bacillus subtilis , Enterococcus faecalis , and Streptococcus salivarius have indicated that the phosphorylation of one residue impedes the phosphorylation of the other. However, a recent study showed that while the rate of Streptococcus salivarius HPr phosphorylation by EI~P is reduced at acidic pH, the phosphorylation of HPr(Ser-P) by EI~P, generating HPr(Ser-P)(His~P), is stimulated. This suggests that HPr(Ser-P)(His~P) synthesis may occur in acidogenic bacteria unable to maintain their intracellular pH near neutrality. Consistent with this hypothesis, significant amounts of HPr(Ser-P)(His~P) have been detected in some streptococci. The present study was aimed at determining whether the capacity to synthesize HPr(Ser-P)(His~P) is common to streptococcal species, as well as to lactococci, which are also unable to maintain their intracellular pH near neutrality in response to a decrease in extracellular pH. Our results indicated that unlike Staphylococcus aureus, B. subtilis, and E. faecalis, all the streptococcal and lactococcal species tested were able to synthesize large amounts of HPr(Ser-P)(His~P) during growth. We also showed that Streptococcus salivarius IIABLMan, a protein involved in sugar transport by the PTS, could be efficiently phosphorylated by HPr(Ser-P)(His~P).
Glenn Gould, the Vanishing Performer and the Ambivalence of the Studio
Authors: Hecker Tim 
Published: November 2008

ABSTRACT
This article examines Canadian pianist Glenn Gould's turn from performance to the recording studio as a means to realize music's utopian potential. What emerged from these post-performance years was a deep ambivalence engendered by the studio itself: a distinctly compelling vision of the studio as a monastic retreat, a site of total control in music and a technology of self-erasure.
New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment
Authors: Cervantes Francisco , Dupriez Brigitte , Pereira Arturo , Passamonti Francesco , Reilly John T. , Morra Enrica , Vannucchi Alessandro M. , Mesa Ruben A. , Demory Jean-Loup , Barosi Giovanni , Rumi Elisa , Tefferi Ayalew 
Published: November 2008

AbstractTherapeutic decision-making in primary myelofibrosis (PMF) is becoming more challenging because of the increasing use of allogeneic stem cell transplantation and new investigational drugs. To enhance this process by developing a highly discriminative prognostic system, 1054 patients consecutively diagnosed with PMF at 7 centers were studied. Overall median survival was 69 months (95% confidence interval [CI]: 61-76). Multivariate analysis of parameters obtained at disease diagnosis identified age greater than 65 years, presence of constitutional symptoms, hemoglobin level less than 10 g/dL, leukocyte count greater than 25 × 109/L, and circulating blast cells 1% or greater as predictors of shortened survival. Based on the presence of 0 (low risk), 1 (intermediate risk-1), 2 (intermediate risk-2) or greater than or equal to 3 (high risk) of these variables, 4 risk groups with no overlapping in their survival curves were delineated; respective median survivals were 135, 95, 48, and 27 months (P < .001). Compared with prior prognostic models, the new risk stratification system displayed higher predictive accuracy, replicability, and discriminating power. In 409 patients with assessable metaphases, cytogenetic abnormalities were associated with shorter survival, but their independent contribution to prognosis was restricted to patients in the intermediate-risk groups. JAK2V617F did not cluster with a specific risk group or affect survival.
Genome-Wide Gene Expression Analysis Reveals a Dynamic Interplay between Luteotropic and Luteolytic Factors in the Regulation of Corpus Luteum Function in the Bonnet Monkey (Macaca radiata)
Authors: Priyanka S. , Jayaram P. , Sridaran R. , Medhamurthy R. 
Published: November 2008

Although LH is essential for survival and function of the corpus luteum (CL) in higher primates, luteolysis occurs during nonfertile cycles without a discernible decrease in circulating LH levels. Using genome-wide expression analysis, several experiments were performed to examine the processes of luteolysis and rescue of luteal function in monkeys. Induced luteolysis with GnRH receptor antagonist (Cetrorelix) resulted in differential regulation of 3949 genes, whereas replacement with exogenous LH (Cetrorelix plus LH) led to regulation of 4434 genes (1563 down-regulation and 2871 up-regulation). A model system for prostaglandin (PG) F2α-induced luteolysis in the monkey was standardized and demonstrated that PGF2α regulated expression of 2290 genes in the CL. Analysis of the LH-regulated luteal transcriptome revealed that 120 genes were regulated in an antagonistic fashion by PGF2α. Based on the microarray data, 25 genes were selected for validation by real-time RT-PCR analysis, and expression of these genes was also examined in the CL throughout the luteal phase and from monkeys treated with human chorionic gonadotropin (hCG) to mimic early pregnancy. The results indicated changes in expression of genes favorable to PGF2α action during the late to very late luteal phase, and expressions of many of these genes were regulated in an opposite manner by exogenous hCG treatment. Collectively, the findings suggest that curtailment of expression of downstream LH-target genes possibly through PGF2α action on the CL is among the mechanisms underlying cross talk between the luteotropic and luteolytic signaling pathways that result in the cessation of luteal function, but hCG is likely to abrogate the PGF2α-responsive gene expression changes resulting in luteal rescue crucial for the maintenance of early pregnancy.Results of genome-wide analyses suggest that curtailment of expression of LH target-genes through PGF2α action in corpus luteum involves cross talk between luteotropic and luteolytic signaling pathways.
S-Glutathionylation Impairs Signal Transducer and Activator of Transcription 3 Activation and Signaling
Authors: Xie Yi , Kole Sutapa , Precht Patricia , Pazin Michael J. , Bernier Michel 
Published: November 2008

S-glutathionylation is a physiological, reversible protein modification of cysteine residues with glutathione in response to mild oxidative stress. Because the key cell growth regulator signal transducer and activator of transcription (STAT) 3 is particularly susceptible to redox regulation, we hypothesized that oxidative modification of cysteine residues of STAT3 by S-glutathionylation may occur. Herein, we show that the cysteine residues of STAT3 are modified by a thiol-alkylating agent and are the targets of S-glutathionylation. STAT3 protein thiol reactivity was reversibly attenuated with concomitant increase in the S-glutathionylation of STAT3 upon treatment of human HepG2 hepatoma cells with pyrrolidine dithiocarbamate, glutathione disulfide, or diamide. Under these conditions there was a marked reduction in IL-6-dependent STAT3 signaling, including decreased STAT3 tyrosine phosphorylation, loss in nuclear accumulation of STAT3, and impaired expression of target genes, such as fibrinogen-γ. In a cell-free system, diamide induced glutathionylation of STAT3, which was decreased upon addition of glutaredoxin (GRX)-1, a deglutathionylation enzyme, or the reducing agent, dithiothreitol. Glutathionylated STAT3 was a poor Janus protein tyrosine kinase 2 substrate in vitro, and it exhibited low DNA-binding activity. Cellular GRX-1 activity was inhibited by diamide and pyrrolidine dithiocarbamate treatment; however, ectopic expression of GRX-1 was accompanied by a modest increase in phosphorylation, nuclear translocation, and DNA-binding ability of STAT3 in response to IL-6. These results are the first to show S-glutathionylation of STAT3, a modification that may exert regulatory function in STAT3 signaling.Reversible S-glutathionylation of STAT3 regulates its activity as transcription factor.
Influence of Different Ceramics on Resin Cement Knoop Hardness Number
Authors: Borges G. A. , Agarwal P. , Miranzi B. A. S. , Platt J. A. , Valentino T. A. , Santos P. H. 
Published: November 2008

Clinical Relevance
Polymerization of a dual resin cement is significantly affected by type of ceramic, activation modes and post-activation times.
Effects of Early Progressive Eccentric Exercise on Muscle Size and Function After Anterior Cruciate Ligament Reconstruction: A 1-Year Follow-up Study of a Randomized Clinical Trial
Authors: Gerber J Parry , Marcus Robin L , Dibble Leland E , Greis Patrick E , Burks Robert T , LaStayo Paul C 
Published: November 2008

Background and PurposeThe authors previously reported that focused eccentric resistance training during the first 15 weeks following anterior cruciate ligament reconstruction (ACL-R) induced greater short-term increases in muscle volume, strength, and measures of function relative to standard rehabilitation. The purpose of this study was to evaluate the effects of early progressive eccentric exercise on muscle volume and function at 1 year after ACL-R.Participants and MethodsForty patients who had undergone an ACL-R were randomly assigned to 1 of 2 groups: a group that received early progressive eccentric exercise (n=20) and a group that received standard rehabilitation (n=20). Seventeen participants in the eccentric exercise group and 15 participants in the standard rehabilitation group completed a 1-year follow-up. Magnetic resonance images of the thighs were acquired 1 year after ACL-R and compared with images acquired 3 weeks after surgery. Likewise, routine knee examinations, self-report assessments, and strength and functional testing were completed 1 year after surgery and compared with previous evaluations. A 2-factor analysis of variance for repeated measures (group × time) was used to analyze the data.ResultsCompared with the standard rehabilitation group, improvements in quadriceps femoris and gluteus maximus muscle volume in the involved lower extremity from 3 weeks to 1 year following ACL-R were significantly greater in the eccentric exercise group. Improvements in quadriceps femoris and gluteus maximus muscle volume were 23.3% (SD=14.1%) and 20.6% (SD=12.9%), respectively, in the eccentric exercise group and 13.4% (SD=10.3%) and 11.6% (SD=10.4%), respectively, in the standard rehabilitation group. Improvements in quadriceps femoris muscle strength and hopping distance also were significantly greater in the eccentric exercise group 1 year postsurgery.Discussion and ConclusionsA 12-week focused eccentric resistance training program, implemented 3 weeks after ACL-R, resulted in greater increases in quadriceps femoris and gluteus maximus muscle volume and function compared with standard rehabilitation at 1 year following ACL-R.