bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthese d'allylamines deuteriees en position specifique
Authors: le Coustumer F. , Lautié M. F. , Dizabo P. 
Published: October 2006

AbstractLes allylamines CH2 = CH ‐ CD2NH2, = CD ‐ CH2NH2, CH2 = CD ‐ CD2NH2, ont été préparées par réduction par AlLiH4 (ou D4), des adduits anthracéniques des acrylonitiles CH2 = CH ‐ CN et CH2 = CD ‐ CN. Pour les allylamines CD2 = CH ‐ CH2NH2 et CD2 = CH ‐ CD2NH2, deux méthodes sont décrites: réduction soit de l'adduit anthracè;ne‐acrylonitrile CD2 = CH‐CN, soit de l'aduit anthracène‐acrylamide CD2 = CH ‐ CONH2.Les allylamines récupérées par décomposition de leurs adduits anthracéniques ont été purifiées par chromatographie en phase vapeur et leur pureté contrôlée par R.M.N.
The chemical and enzymatic syntheses of specifically deuterated dinucleoside monophosphates
Authors: Kondo N. S. , Leung A. , Danyluk S. S. 
Published: October 2006

AbstractProton magnetic resonance (pmr) studies of nucleic acid structure are currently hampered by extensive overlapping of signals, particularly in the ribose region. An approach with considerable promise involves the preparation of oligomers with specifically deuterated nucleotidyl units at known positions. In this publication, we report the synthesis of five dinucleoside monophosphates in which the 3′‐nucleotidyl unit is deuterated. These compounds were prepared by standard chemical procedures and an enzymatic approach using ribonuclease T1. The deuterated dimers give pmr spectra which are much simpler than their protio analogs, thus permitting unambiguous peak assigments.
Syntheses with stable isotopes: Synthesis of deuterium and 13C labeled bile acids
Authors: Hachey D. L. , Szczepanik P. A. , Berngruber O. W. , Klein P. D. 
Published: October 2006

AbstractA series of 5β‐cholanic acids labeled with deuterium in the A ring were prepared by exchange labeling of the corresponding ketone by column chromatography on deuterated alumina. Factors affecting yield and labeling efficiency are discussed. 5β‐Cholanic acids labeled with 13C in the carboxyl position were prepared by treatment of the corresponding 23‐chloro‐24‐norcholane with sodium cyanide‐13C followed by alkaline hydrolysis of the nitrile. The intermediates in the synthesis were characterized by high resolution NMR spectroscopy. Mass spectra are also reported for the 13C labeled products.
Methode de synthese et D'etude par spectrometrie infrarouge des composes de coordination de molecules marquees application aux complexes de l'acetone et du trifluorure de bore
Authors: Cornut Jean Claude , Fouassier Monique , Forel Marie‐Thérèse 
Published: October 2006

AbstractLa synthése et l'étude spectroscopique des composés d'addition de molécules marquées avec des isotopes lourds présentent de nombreuses difficultés en raison des faibles quantités de produit qui doivent être utilisées. Une méthode de piégeages à basse température est proposée, elle est illustrée par l'étude des complexes de l'acétone 18 et du triifluorure de bore 10B.
Determination of purity of some tritiated steroids
Authors: Merill Edward J. , Vernice Gerald G. 
Published: October 2006

AbstractWhen radiolabeled steroids at high specific activities are required for biological studies, the particular requirements of purity must be determined. The analyses to which the compound is subjected is based on these requirements. Analytical methods are complicated because of the radiochemical instability and the lack of aufficient sample. Methods have been developed which will allow IR and UV spectra to be determined with subsequent recovery of the sample. A prime requisite for this is specially purified solvents. The acceptability of certain solvents for this use can be determined by concentrating an aliquot of the solvent and then examining the residue by TLC. Spraying the developed chromatogram with a 5% solution of phosphomolybdic acid in ethanol, followed by heating will reveal the presence of impurities in the solvents. These impurities appear as spots and can readily be misinterpreted as contaminants in the sample if unpurified solvents are used to manipulate a pure steroid. Problems associated with the determination of radiochemical purity via GLC and TLC will be discussed. The synthesis of tritiated ethynyl estraniol its cyclopentul ether and the cyclopentyl ether of norethinarone acetate will illustrate the above problems.
Molecular Cloning and Characterization of NAD+‐Dependent Xylitol Dehydrogenase from Candida tropicalis ATCC 20913
Authors: Ko Byoung Sam , Jung Heung Chae , Kim Jung Hoe 
Published: October 2006

AbstractInduction of xylitol dehydrogenase of Candida tropicalis ATCC 20913 by various carbon sources was investigated. The enzyme activity was induced when the yeast was grown on l‐arabinose and d‐xylose. A novel gene encoding the enzyme was cloned and characterized. The 1,095‐bp coding sequence of the gene encodes a polypeptide of 364 amino acids, with a molecular mass of 39.4 kDa. Sequence analysis of the putative protein showed it to be a member of the zinc‐containing alcohol dehydrogenase family and to have homology to xylitol dehydrogenase genes from other yeasts and fungi. The recombinant xylitol dehydrogenase expressed in Escherichia coli oxidized polyols such as xylitol and d‐sorbitol and reduced ketoses such as d‐xylulose and d‐fructose. It required exclusively NAD or NADH as a cofactor.
Abiotic Stress Generates ROS That Signal Expression of Anionic Glutamate Dehydrogenases to Form Glutamate for Proline Synthesis in Tobacco and Grapevine
Authors: Skopelitis Damianos S. , Paranychianakis Nikolaos V. , Paschalidis Konstantinos A. , Pliakonis Eleni D. , Delis Ioannis D. , Yakoumakis Dimitris I. , Kouvarakis Antonios , Papadakis Anastasia K. , Stephanou Euripides G. , Roubelakis-Angelakis Kalliopi A. 
Published: October 2006

AbstractGlutamate dehydrogenase (GDH) may be a stress-responsive enzyme, as GDH exhibits considerable thermal stability, and de novo synthesis of the α-GDH subunit is induced by exogenous ammonium and senescence. NaCl treatment induces reactive oxygen species (ROS), intracellular ammonia, expression of tobacco (Nicotiana tabacum cv Xanthi) gdh-NAD;A1 encoding the α-subunit of GDH, increase in immunoreactive α-polypeptide, assembly of the anionic isoenzymes, and in vitro GDH aminating activity in tissues from hypergeous plant organs. In vivo aminating GDH activity was confirmed by gas chromatorgraphy–mass spectrometry monitoring of 15N-Glu, 15N-Gln, and 15N-Pro in the presence of methionine sulfoximine and amino oxyacetic acid, inhibitors of Gln synthetase and transaminases, respectively. Along with upregulation of α-GDH by NaCl, isocitrate dehydrogenase genes, which provide 2-oxoglutarate, are also induced. Treatment with menadione also elicits a severalfold increase in ROS and immunoreactive α-polypeptide and GDH activity. This suggests that ROS participate in the signaling pathway for GDH expression and protease activation, which contribute to intracellular hyperammonia. Ammonium ions also mimic the effects of salinity in induction of gdh-NAD;A1 expression. These results, confirmed in tobacco and grape (Vitis vinifera cv Sultanina) tissues, support the hypothesis that the salinity-generated ROS signal induces α-GDH subunit expression, and the anionic iso-GDHs assimilate ammonia, acting as antistress enzymes in ammonia detoxification and production of Glu for Pro synthesis.
Identification of a novel mutation in hereditary vitamin D resistant rickets causing exon skipping
Authors: Hawa N. S. , Cockerill F. J. , Vadher S. , Hewison M. , Rut A. R. , Pike J. W. , O'Riordan J. L. H. , Farrow S. M. 
Published: October 2006

SummaryOBJECTIVE Hereditary vitamin D resistant rickets (HVDRR) is an autosomal recessive disorder resulting in target organ resistance to the actions of 1,25‐dihydroxyvitamin D3 (1,25(OH)2D3). In many cases, this disorder has been shown to be due to mutations in the gene encoding vitamin D receptors (VDR). In a patient with characteristic features of this disorder, we investigated the functional defect and sequenced the coding region of the gene for mutations.DESIGN Skin fibroblasts from patient and control were used to measure binding of 1,25(OH)2D3 and functional responses to the hormone. These cells were also used to prepare RNA from which cDNA was prepared and sequenced. Furthermore, genomic DNA was prepared from the fibroblasts and the intronlexon boundarles sequenced.PATIENT A child with classic features of HVDRR with alopecia diagnosed as having rickets due to resistance to 1,25(OH)2D3.MEASUREMENTS Nuclear association of 1,25(OH)2D3 was determined in patient and control cells and the functional response to 1,25(OH)2D3 was assessed by measurement of 25‐hydroxyvitamln D‐24‐hydroxylase(24‐hydroxylase) activity. VDR cDNA and genomic DNA prepared from patient and control cells were sequenced.RESULTS Cells from the patient with HVDRR had undetectable amounts of VDR compared to control cells and did not show induction of 24‐hydroxylase activity following treatment with 1,25(OH), D3. Sequencing of the VDR coding region after RT‐PCR of RNA revealed an absence of exon 4 in patient RNA which was not due to a deletion in genomic DNA but was caused by exon skipping during RNA processing. In addition, the deletion of exon 4 sequences from RNA leads to a frameshift in translation resulting in a premature stop codon. Amplification of genomic DNA around the intron/exon boundary of exon 4 revealed a point mutation in the 5’donor splice site of intron 4.CONCLUSION In this study, we have identified a novel mutation in the gene for vitamin D receptors in a patient with the Characteristic phenotype of hereditary vitamin D resistant rickets. The mutation at the + 5 position in intron 4 is most likely to cause skipping of exon 4 in this patient.
Signal Transduction by Human Herpesvirus 8 Viral Interleukin-6 (vIL-6) IsModulated by the Nonsignaling gp80 Subunit of the IL-6 Receptor Complex and Is Distinct from Signaling Induced by Human IL-6
Authors: Hu Fang , Nicholas John 
Published: October 2006

ABSTRACT

Human
herpesvirus 8 (HHV-8) viral interleukin-6 (vIL-6) mediates signaling
through the gp130 signal transducer but unlike human IL-6 (hIL-6) does
not require the nonsignaling gp80 α subunit of the IL-6
receptor complex. By utilizing a gp80-refractory vIL-6 variant,
vIL-6(R189L), we found that signal transduction, as measured by STAT1
and STAT3 activation and gp130 tyrosine phosphorylation in
gp80
+
/gp130
+
HEK293T cells, was
modulated by gp80. Furthermore, the signaling and BAF-130 cell
growth-promoting activities of vIL-6 and hIL-6 could be distinguished,
and exogenous addition of soluble gp80 enhanced cell growth supported
by vIL-6. Our findings demonstrate that gp80 can modulate vIL-6
activity and that vIL-6 and hIL-6 signaling are not directly
equivalent.
Kaposi's Sarcoma-Associated Herpesvirus LANA-1 Interacts with the Short Variant of BRD4 and Releases Cells from a BRD4- and BRD2/RING3-Induced G
1
Cell CycleArrest
Authors: Ottinger Matthias , Christalla Thomas , Nathan Kavita , Brinkmann Melanie M. , Viejo-Borbolla Abel , Schulz Thomas F. 
Published: October 2006

ABSTRACT

The Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated
nuclear antigen 1 (LANA-1) is required for the replication of episomal
viral genomes. Regions in its N-terminal and C-terminal domains mediate
the interaction with host cell chromatin. Several cellular nuclear
proteins, e.g., BRD2/RING3, histones H2A and H2B, MeCP2, DEK, and
HP1α, have been suggested to mediate this interaction. In this
work, we identify the double-bromodomain proteins BRD4 and BRD3/ORFX as
additional LANA-1 interaction partners. The carboxy-terminal region of
the short variant of BRD4 (BRD4
S
) containing the highly
conserved extraterminal domain directly interacts with an element in
the LANA-1 carboxy-terminal domain. We show that ectopically expressed
BRD4
S
and BRD2/RING3 delay progression into the S phase of
the cell cycle in epithelial and B-cell lines and increase cyclin E
promoter activity. LANA-1 partly releases epithelial and B cells from a
BRD4
S
- and BRD2/RING3-induced G
1
cell cycle
arrest and also promotes S-phase entry in the presence of
BRD4
S
and BRD2/RING3. This is accompanied by a reduction in
BRD4
S
-mediated cyclin E promoter activity. Our data are in
keeping with the notion that the direct interaction of KSHV LANA-1 with
BRD4 and other BRD proteins could play a role in the G
1
/S
phase-promoting functions of KSHV LANA-1. Further, our data support a
model in which the LANA-1 C terminus contributes to a functional
attachment to acetylated histones H3 and H4 via BRD4 and BRD2, in
addition to the recently demonstrated direct interaction (A.
J. Barbera, J. V. Chodaparambil, B. Kelley-Clarke, V. Joukov,
J. C. Walter, K. Luger, and K. M. Kaye, Science
311:856-861, 2006) of the LANA-1 N terminus with histones H2A
and
H2B.
Pseudorabies Virus EP0 Protein Counteracts an Interferon-Induced Antiviral State in a Species-Specific Manner
Authors: Brukman Alla , Enquist L. W. 
Published: October 2006

ABSTRACT
Pseudorabies virus (PRV), an alphaherpesvirus related to herpes simplex virus type 1 and varicella-zoster virus, infects a broad host range of mammals. A striking characteristic of PRV infection is the different symptoms and outcomes of infection in natural and nonnatural hosts. Adult pigs, the natural hosts of PRV, survive infection with only mild respiratory symptoms, while nonnatural hosts, including rodents and cattle, invariably die after exhibiting neurological symptoms. Here, we show that the PRV EP0 protein is necessary to overcome an interferon-mediated antiviral response in primary cells from the natural host of PRV but is not necessary in nonnatural-host cells.
Nef Alleles from Human Immunodeficiency Virus Type 1-InfectedLong-Term-Nonprogressor Hemophiliacs with or without Late Disease Progression Are Defective in Enhancing Virus Replication and CD4 Down-Regulation
Authors: Crotti Andrea , Neri Francesca , Corti Davide , Ghezzi Silvia , Heltai Silvia , Baur Andreas , Poli Guido , Santagostino Elena , Vicenzi Elisa 
Published: October 2006

ABSTRACT

Infection
with human immunodeficiency virus (HIV)-encoding defective
nef
variants may contribute to a relatively benign course of disease in a
minority of long-term nonprogressors (LTNP). We have examined the
functions of
nef
alleles from six individuals belonging to the
same cohort of hemophiliacs infected with HIV-1 prior to 1985 and
classified as LTNP in 1995. Three out of six individuals have
progressed to HIV disease (late progressors [LP]), whereas the three
remainders have maintained their LTNP status at least up to 2003. The
nef
alleles were obtained from both plasma virus and
peripheral blood mononuclear cells of all six individuals in 1995 and
1998. The proportion of sequences containing mutations not yielding Nef
expression significantly diminished in 1998 versus that in 1995.
Several previously defined functional regions of intact
nef
alleles were highly conserved. However, the major variant obtained in
1998 from plasma RNA of five out of six individuals significantly
reduced HIV infectivity/replication and impaired Nef-mediated CD4 but
not major histocompatibility complex class I antigen down-modulation
from the cell surface. Thus, functional alterations of the
nef
gene are present in both LP and LTNP, suggesting that Nef defectiveness
in vitro is not necessarily associated with the long-term maintenance
of LTNP status. Of interest is the fact that isolates from three out of
three LP showed a dual CCR5/CXCR4 coreceptor use (R5X4), in contrast to
those from LTNP, which were exclusively R5. Thus, in vivo evolution of
gp120 Env to CXCR4 use appears to be associated with HIV disease
progression in individuals infected with
nef
-defective
viruses.
Sensitive Detection of KIT D816V in Patients with Mastocytosis
Authors: Tan Angela , Westerman David , McArthur Grant A , Lynch Kevin , Waring Paul , Dobrovic Alexander 
Published: October 2006

Abstract
Background: The 2447 A&gt;T pathogenic variation at codon 816 of exon 17 (D816V) in the KIT gene, occurring in systemic mastocytosis (SM), leads to constitutive activation of tyrosine kinase activity and confers resistance to the tyrosine kinase inhibitor imatinib mesylate. Thus detection of this variation in SM patients is important for determining treatment strategy, but because the population of malignant cells carrying this variation is often small relative to the normal cell population, standard molecular detection methods can be unsuccessful.
Methods: We developed 2 methods for detection of KIT D816V in SM patients. The first uses enriched sequencing of mutant alleles (ESMA) after BsmAI restriction enzyme digestion, and the second uses an allele-specific competitive blocker PCR (ACB-PCR) assay. We used these methods to assess 26 patients undergoing evaluation for SM, 13 of whom had SM meeting WHO classification criteria (before variation testing), and we compared the results with those obtained by direct sequencing.
Results: The sensitivities of the ESMA and the ACB-PCR assays were 1% and 0.1%, respectively. According to the ACB-PCR assay results, 65% (17/26) of patients were positive for D816V. Of the 17 positive cases, only 23.5% (4/17) were detected by direct sequencing. ESMA detected 2 additional exon 17 pathogenic variations, D816Y and D816N, but detected only 12 (70.5%) of the 17 D816V-positive cases. Overall, 100% (15/15) of the WHO-classified SM cases were codon 816 pathogenic variation positive.
Conclusion: These findings demonstrate that the ACB-PCR assay combined with ESMA is a rapid and highly sensitive approach for detection of KIT D816V in SM patients.
Hat Sertürner reines Morphin isoliert? Zur papierchromatographischen Reinheitsprüfung von Alkaloiden
Authors: Häussermann H. , Schecker H.‐J. 
Published: October 2006

AbstractIm „Sertürner‐Jahr”︁ 1955 gab unser verehrter Lehrer, Prof. v. Bruchhausen, uns die Anregung: „In Ihrer Apotheke hat doch früher Sertürner gearbeitet. Prüfen Sie doch mal nach, ob er wirklich reines Morphin isoliert hat.”︁ Diesem Gedanken sind wir gefolgt. Die erste Nacharbeit erfolgte durch Robiquet, der einst einen ähnlichen Auftrag von seinem Lehrer Gay‐Lussac erhielt (1) (2). Die Anregung führte allgemein zu Arbeiten über die papierchromatographische Reinheitsprüfung von Alkaloiden, die noch nicht abgeschlossen sind. Über die Ergebnisse bei der Bearbeitung der speziellen Sertürner‐Morphin‐Frage soll hier berichtet werden.
Über die Chlormethylierung des o‐ und Novo‐vanillins und die Gewinnung von 4‐Hydroxy‐5‐alkoxy‐isophthalaldehyden
Authors: Profft E. , Kŕause W. 
Published: October 2006

AbstractDie Chlormethylierung des o‐ und Novo‐Vanillins wurde durchgeführt. Nach Sommelet konnten daraus die entsprechenden 4‐Hydroxy‐5‐alkoxyisophthalaldehyde erhalten werden. Eine einfache Methode zur Darstellung dieser wurde erarbeitet und eine Reihe von Chlormethylverbindungen synthetisiert.
Potentialverlauf bei der Quecksilberacetat‐Dehydrierung von tertiären Aminen mit und ohne ÄDTA. 3. Mitt.: Darstellung von Hydroxylactamen durch Quecksilber(II)‐ÄDTA‐Dehydrierung
Authors: Möhrle H. , Rohrer H. , Altenschmidt W. 
Published: October 2006

AbstractDie vergleichenden Messungen des Potentials bei der Dehydrierung von Spartein und Nicotin mit Quecksilber(II)‐acetat und Quecksilber(II)‐ÄDTA liefern folgende Ergebnisse:
1. Die Dehydrierung mit Quecksilber(II)‐acetat erfolgt stets bei höherem Potential als mit Quecksilber(II)‐ÄDTA, was auch durch theoretische Berechnungen bestätigt wird.
2 Bei der Umsetzung der Amine mit Quecksilber(II)‐ÄDTA entstehen ebenso wie bei der Reaktion mit Quecksilber(II)‐acetat primär Quecksilber(I)‐Ione, die von ÄDTA zu Quecksilber(II)‐Ionen und Quecksilber disproportioniert werden.
Die Acylierung primärer Alkohole mit Dialkyl‐aminoäthanol‐Esterbasen
Authors: Eckert Th. 
Published: October 2006

AbstractDialkyl‐aminoäthanol‐Esterbasen können zur Acylierung primärer Alkohole verwendet werden. Da hier tertiäres Amin und umzusetzende Estergruppe covalent miteinander verbunden sind, kommt es bei Verwendung der Esterbasen als basische Katalysatoren der eigenen Alkoholyse zu einer katalytischen Kettenreaktion. In wasserfreien und wäßrigen Medien werden eine Reihe von neuen Estern, insbesondere Ester der Hydroxyalkyl‐xanthine, synthetisiert.
Beiträge zur Darstellung und Analytik alkylsubstituierter Pyridincarbonsäuren. 2. Mitt.: Die Darstellung methyl‐ und äthylsubstituierter Pyridincarbonsäuren
Authors: Reppel L. , Eilhauer H. D. , Kretschmer P. 
Published: October 2006

AbstractZur analytischen Prüfung werden Methyl‐ und Äthyl‐pyridinmonocarbonsäuren durch direkte Sulfonierung von Pyridinbasen und durch Aufbau des Pyridinringes dargestellt: 2‐, 4‐, 5‐, 6‐Methyl‐nicotinsäure, 2‐, 4‐, 5‐, 6‐Äthylnicotinsäure und 5‐Äthyl‐picolinsäure.
Umsetzungsgeschwindigkeiten bei der Quecksilberacetat‐Dehydrierung von Spartein und Nicotin mit und ohne Zusatz von ÄDTA. 4. Mitt.: Darstellung von Hydroxylactamen durch Quecksilber(II)‐ÄDTA‐Dehydrierung
Authors: Möhrle H. , Rohrer H. , Altenschmidt W. 
Published: October 2006

AbstractPotentialverlauf und Reaktionsgeschwindigkeit im Temperaturbereich 30 bis 85° bei der Dehydrierung von Spartein und Nicotin mit Quecksilber(II)‐acetat bzw. Quecksilber(II)‐ÄDTA ergeben folgende Befunde:
A) Das vom System Platin‐Kalomel‐Elektrode angezeigte Potential des Reaktionsgemisches ist bei der Dehydrierung mit Quecksilber(II)‐acetat höher als bei der Umsetzung mit Quecksilber(II)‐ÄDTA
B) Die Dehydrierung der organischen Substanzen verläuft mit Quecksilber‐(II)‐acetat langsamer als mit Quecksilber(II)‐ÄDTA
C) Bei der Umsetzung der organischen Verbindung mit Quecksilber(II)‐ÄDTA entstehen ebenso wie bei der Reaktion mit Quecksilber(II)‐acetat primär Quecksilber(I)‐ionen.
Zum Mechanismus der Reduktion Schiffscher Basen mit aktiviertem Aluminium. 3. Mitt. über Cytostatica
Authors: Schönenberger H. , Thies H. , Rappl A. 
Published: October 2006

AbstractBei der Reduktion Schiffscher Basen mit aktiviertem Aluminium lassen sich die Ausbeuten an monomeren und dimeren Reduktionsprodukten durch Zugabe unterschiedlicher Alkoholmengen beliebig variieren. Kleine Alkoholmengen begünstigen die Bildung der dimeren, große hingegen die der monomeren Reduktionsprodukte.
Über die Herstellung neuer lokalanästhetisch wirksamer Verbindungen
Authors: Schönenberger H. , Vogel H. , Bamann E. 
Published: October 2006

AbstractEs werden Verfahren zur Herstellung von „doppelt ringoffenem Cocain und Norcocain”︁ beschrieben. Geeignet sind zwei Verfahren, die von Acetessigester bzw. Crotonester und Aminoalkoholen ausgehen und zu den Zwischenprodukten β‐Hydroxyalkylaminobuttersäureestern führen. Durch Benzoylierung werden aus diesen die lokalanästhetisch wirksamen Verbindungen N‐Methyl‐N‐(3‐n‐butanol‐1‐benzoesäureester)‐β‐aminobuttersäuremethylester und N‐(3‐n‐Butanol‐1‐benzoesäureester)‐β‐aminobuttersäuremethylester hergestellt.
Über die Papaverrubine A und E. 4. Mitt.: Rotfärbungsalkaloide der Gattung Papaver
Authors: Pfeifer S. , Banerjee S. K. 
Published: October 2006

AbstractEs werden Isolierung und Eigenschaften der Papaverrubine A und E aus Papaver rhoeas L. beschrieben. Im Hinblick auf das allgemeine chemische Verhalten und auf Grund von Untersuchungen zur Rotfärbungsreaktion muß eine große strukturelle Ähnlichkeit dieser Stoffe mit dem aus Opium isolierten Porphyroxin bestehen.
Acyl‐tetrahydro‐homophthalsäureanhydride. 3. Mitt. über Acylderivate methylenaktiver Dicarbonylverbindungen
Authors: Schnekenburger J. 
Published: October 2006

Abstract5,6,7,8‐Tetrahydro‐homophthalsäureanhydrid läßt sich in Gegenwart von N,N‐Dimethylanilin durch Carbonsäurechloride zu Enolestern von 4‐Acyl‐5,6,7,8‐tetrahydrohomophthalsäureanhydriden, in Gegenwart von Pyridin durch Chloride aliphatischer Carbonsäuren zu 4‐Acyl‐5,6,7,8‐tetrahydro‐homophthalsäureanhydriden acylieren. Die Umsetzung mit Chloriden aromatischer Carbonsäuren führt in Gegenwart von Pyridin zu neutralen stickstoff‐haltigen Verbindungen. 4‐Aroyl‐5,6,7,8‐tetrahydro‐homophthalsäureanhydride lassen sich durch pyridinkatalysierte Partialhydrolyse ihrer Enolester darstellen.