bluuebunny/crossref_metadata_2025_split huggingface dataset:
FEATURES OF THE EDUCATIONAL PROCESS AT INSTITUTIONS OF SECONDARY VOCATIONAL EDUCATION IN CONDITIONS OF MULTICULTURAL EDUCATIONAL ENVIRONMENT
Authors: Абдулаев М.А. 
Published: April 2024

В статье рассматриваются наиболее значимые особенности педагогического процесса, реализуемого в учреждениях среднего профессионального образования, функционирующих в поликультурной среде. Существенное внимание при этом уделяется трём группам факторов поликультурности, оказывающим различное влияние на результаты учебно-воспитательного процесса. Далее анализируются особенности учебной и внеучебной деятельности, организованной с учётом этих факторов. Приводятся конкретные формы работы. При этом отдельно говорится о роли педагогического работника.
The article focuses on the most significant features of pedagogical process at institutions secondary vocational education functioning in a multicultural educational environment. Considerable attention is paid to three groups of multicultural factors that can have different impacts on the educational process results. Further, the article addresses the features of educational and extracurricular activities organized taking into account these factors. Specific forms of work are considered, and the role of a teacher is separately treated.
DEVELOPMENT OF PRODUCTIVE SUBJECTIVE POSITION OF UNIVERSITY STUDENTS AS A PEDAGOGICAL PROBLEM
Authors: Писарев А.С. 
Published: April 2024

В статье рассматривается проблема развития продуктивной субъектной позиции студентов вуза как необходимого компонента личностного развития обучающихся в ходе учебного процесса и как средства достижения академических результатов обучения. Целенаправленные усилия преподавателей по созданию условий для формирования и развития субъектной позиции у студентов вуза в результате способны принести плоды в виде улучшения количественных и качественных характеристик учебной деятельности, с одной стороны, и достижения студентами личностных результатов, значимых как для их дальнейшей социальной, так и профессиональной деятельности. Продуктивность субъектной позиции студентов вуза в данной статье рассматривается как интегральная характеристика, связанная в первую очередь с учебной деятельностью и направленностью на её результативность.
The article considers the development of the productive subjective position of university students as a necessary component of their personal development during the educational process at university and also as a means for the achievement of academic learning outcomes. The purposeful efforts of teachers aimed at creating conditions for the formation and development of the students’ subjective position can result in improving quantitative and qualitative characteristics of educational activities on the one hand, and achieving personal results by the students that are significant both for their further social and professional activities. The productivity of the subjective position of university students is considered as an integral characteristic associated first of all with educational activity and focus on its effectiveness.
Fluctuation of Disease Severity and Quality of Life Applying Intra-lymphatic Immunotherapy for Patients with Seasonal Allergic Rhinitis
Authors: Khoshkhui Maryam , Jabbari Farahzad , Zargar Fateme Shafiee , Motevalli Haghi Nasrin Sadat , Ariaee Nazila 
Published: April 2024

Allergen-specific immunotherapy is the only disease-modifying treatment for IgE-mediated allergic disorders. Intra lymphatic immunotherapy (ILIT) is an efficacious and time-saving alternative to subcutaneous immunotherapy (SCIT). This study aimed to evaluate the effects and safety of ILIT in patients with moderate to severe allergic rhinitis.
In this clinical trial, patients between 18 and 65 years old with moderate to severe allergic rhinitis were enrolled. They received monthly intra-lymphatic inguinal injections of an active allergen (1000 SQ-U Salsola kali pollen). Their clinical symptoms were assessed before and four weeks after treatments. The clinical signs were also evaluated during two consecutive pollination seasons and the following non-pollination season in April.
No moderate or severe reactions were recorded following ILIT treatment. Lymph node enlargement, angioedema/urticaria, and local itching were seen instantly after injection. Patients who received ILIT experienced a significant clinical improvement in self-recorded seasonal allergic symptoms after the treatments, compared to themselves before ILIT. Furthermore, their quality of life significantly improved.
This study suggests ILIT with Salsola-pollen extract may decrease symptoms of allergic rhinitis. It was safe and did not cause any crucial complications.
The Effect of Priming new Plastic Spacers with 20 Puffs Salbutamol on Bronchodilator Response in Asthmatic Children
Authors: Sadri Homa , Fazlollahi Mohammad Reza 
Published: April 2024

The static charge on the plastic body of spacers attracts drug aerosols, reducing the drug available for inhalation from plastic spacers. Some instructions exist to decrease the electric charge on plastic spacers, such as priming them with salbutamol (20 puffs) before use. This study investigates whether priming plastic spacer devices with this method can improve the bronchodilator test result.
This study included children with stable mild to moderate asthma. All subjects underwent two pulmonary function tests to evaluate their bronchodilator response on separate days at 24-48 hours intervals. On each day, spirometry was performed at the baseline and 15 min after inhalation of four puffs of salbutamol (100 μg/puff) through either a primed or a new spacer. The change in forced expiratory volume in the first second (FEV1) after inhaling salbutamol was the primary outcome measure.
When the patients used a new spacer, the mean baseline FEV1 (% predicted) and FEV1/FVC (forced vital capacity) were 89.56±11.95 and 86.17±6.87, respectively. However, the mean increase in FEV1 from the baseline was 10.87±8.99 in this group. On the other hand, with the primed spacer, the respective mean baseline FEV1 and FEV1/FVC values were 89.41±12.14 and 85.49±6.76, while it increased by 12.1±11.01 after salbutamol inhalation. There were no significant differences between the techniques regarding the variation in FEV1 before and after bronchodilator use via a new spacer or primed spacer.
Priming new plastic spacers with 20 puffs of salbutamol did not cause additional bronchodilation in asthmatic children, suggesting this practice is inefficient in clinics.
Identification and assessment of antifungal susceptibility of Candida species based on bronchoalveolar lavage in immunocompromised and critically ill patients
Authors: Rezaei Robabeh , Aliannejad Rasoul , Falahati Mehraban , Ghasemi Zeinab , Ashrafi-Khozani Mahtab , Fattahi Mahsa , Razavi Tandis , Farahyar Shirin 
Published: April 2024

Background and Objectives: The presence of fungi in the respiratory tract as mycobiome, particularly Candida species (spp.), remains a serious problem due to increasing numbers of immunocompromised patients. The confirmed reliable ex- istence of these pathogens due to frequent colonization is essential. This investigation aimed to recognize Candida spp. among isolates from bronchoalveolar lavage of immunocompromised and critically ill patients and to evaluate their suscep- tibility to antimycotic drugs.
Materials and Methods: Bronchoalveolar lavage fluid was collected from 161 hospitalized patients presenting with sus- pected respiratory fungal infection /colonization. The specimens were examined by standard molecular and mycological assays. Candida spp. were recognized with sequence assessment of the D1-D2 section of the large subunit ribosomal DNA. The susceptibility of Candida isolates to common antimycotic drugs was distinguished by standard broth microdilution.
Results: Seventy-one clinical isolates of Candida spp. were recognized. Candida albicans was the most frequent, followed by C. glabrata, C. krusei (Pichia kudriavzevii), C. dubliniensis, C. parapsilosis, and C. tropicalis. We found 5.1% of C. albi- cans isolates and 8% of C. glabrata isolates to show resistance to fluconazole. The whole of the Candida spp. were sensitive to amphotericin B and caspofungin.
Conclusion: This study demonstrated that C. albicans and C. glabrata are the most common isolates of bronchoalveolar lavage fluid in patients, and the drug susceptibility screening confirmed that amphotericin B and caspofungin are effective against Candida spp. but some C. glabrata and C. albicans isolates showed resistance to fluconazole.
Schistosoma mansoni Infection and Hepatocellular Carcinoma: A Comorbidity Study
Authors: Allam Amal Farahat , Farag Hoda , Shehab Amel , Sahy Ahmed El , Khalil Safia , El-Latif Naglaa Abd 
Published: April 2024

Abstract

Background The implication of human Schistosoma mansoni (S. mansoni) infection in concomitance with other risk factors such as hepatitis C virus (HCV) and hepatitis B virus (HBV) in the development of hepatocellular carcinoma (HCC) is still under controversy. This work aimed
to evaluate the role of S. mansoni infection in association with hepatitis B virus (HBV), hepatitis C virus (HCV) and other risk factors in the development and/or progress of HCC.
Methods The present study was carried out on 90 HCC patients recruited from Kafr El-Sheikh Liver Disease Research Institute. After obtaining their informed consents, socio-demographic and clinical data were collected and patients were examined for S. mansoni by Kato-Katz and indirect hemagglutination (IHA) techniques. Alpha-fetoprotein (AFP) level was determined. The Child-Pugh scoring system and Barcelona Clinic Liver Cancer (BCLC) staging system were used to evaluate the pathological features of the studied patients.
Results All participants were negative for active S. mansoni by Kato-Katz. Based on IHA, the participants were categorized into two groups: group I: sixty-two patients negative for S. mansoni and group II: twenty-eight schistosomiasis positive. The patients’ age ranged between 40->60 years with a mean of 57.07± 8.12 years. HCC was more prevalent in the age range of >50-60 years in both groups. Males were more than females and rural participants were more than urban patients in both groups. Most of the patients (88.9%) had HCV while 7.8% had HBV. A higher proportion of HCC patients showed concomitant HCV and S. mansoni (92.6%) than the S. mansoninegative group. Alpha-fetoprotein (AFP) level was higher in group II than that in group I with no significant difference. Statistical analysis showed no difference between the two studied groups regarding Child scores. On the contrary, BCLC class D was significantly higher among HCC positive schistosomiasis cases compared to the negative group.
Conclusion Concomitant S. mansoni with HCV and HBV potentiate HCC progression.
Plasma bioactive adrenomedullin predicts mortality and need for dialysis in critical COVID-19
Authors: Johnsson Patrik , Sievert Theodor , Didriksson Ingrid , Friberg Hans , Frigyesi Attila 
Published: April 2024

Abstract

COVID-19 is a severe respiratory disease affecting millions worldwide, causing significant morbidity and mortality. Adrenomedullin (bio-ADM) is a vasoactive hormone regulating the endothelial barrier and has been associated with COVID-19 mortality and other adverse events.
This prospective cohort study included 119 consecutive patients with verified SARS-CoV-2infection admitted to the intensive care unit (ICU). Bio-ADM was retrospectively analysed from plasma on ICU admission, day2, and day 7. Information on comorbidities, adverse events and mortality was collected. The primary outcome was 90-daymortality, and secondary outcomes were markers of disease severity. The association between bio-ADM and outcomes was analysed using survival analysis, logistic regression and receiver operating characteristics curves.
Bio-ADM predicts 90-daymortality with an area under the receiver operating Curve (AUC) of 0.66, 0.68, and 0.70 for sampling on admission, day 2 and day 7. Age alone predicted 90-day mortality with an AUC of 0.78. The AUCs for age combined with bio-ADM were 0.81, 0.81,and 0.82 (n.s.). Bio-ADM predicted the need for renal replacement therapy with AUCs of 0.77, 0.82, and 0.81.
Bio-ADM on ICU admission, day 2 and day 7 predicted 90-day mortality and dialysis needs, which highlights the importance of bio-ADM inCOVID-19 pathophysiology. Bio-ADM could be used to triage patients with a risk of adverse outcomes and as a potential target for clinical interventions
Effect of Metakaolin and Lime addition on Geopolymerization of Construction and Demolition Waste
Authors: Pathak Arvind , Kumar Sanjay , Jha Vinay Kumar 
Published: April 2024

Abstract

New challenges are arising everyday due to the waste management problems. Construction is one of the most important activities and it is seen as a real threat to sustainable development considering permanent use of limited natural resources and the disposal of huge amount of debris. Construction and demolition wastes contain aluminosilicates as major constituents. In this study an attempt has been made to investigate the mechanical effect of the addition of metakaolin and lime to synthesize geopolymer using construction waste. The compressive strengths of the geopolymer products developed at 28 days from brick dust, metakaolin and lime with activator solution were found 8.35, 21.30 and 25.0 MPa, respectively. Addition of metakaolin and lime had increased the compressive strength by more than 2.5 and 3.0 folds respectively in comparison to the product obtained from brick dust only. The FTIR spectra and SEM-EDX micrographs of the reaction had shown structural changes and formation of aluminosilicate hydrate and calcium silicate hydrate gel. Geopolymer synthesized from brick dust was found very hard ceramic like product with potential applications such as pavement blocks, tiles, retaining walls etc.
Capturing biological interactions improves predictive ability of complex traits via epistatic model
Authors: Gao Ning , Teng Jinyan , Ye Shaopan , Lin Qing , Gao Yahui , Wang Jiaying , Huang Shuwen , He Jun , Li Jiaqi , Chen Yaosheng , Fang Lingzhao , Zhang Qin , Zhang Zhe 
Published: April 2024

Abstract

Recent studies have emphasized the significance of epistatic effects in unraveling the underlying genetic architectures of complex traits. However, the rich landscape of biological interactions is often disregarded when statistically modeling epistatic effects for the purpose of dissecting and predicting complex traits/diseases. In this study, we utilize KEGG pathways as carriers of biological interactions, thereby bridging the gap between statistical and biological interactions and enable to capture the epistatic effects of complex traits. We introduce biBLUP (biological interaction best linear unbiased prediction) model for modelling the epistatic effects among genes from the KEGG pathways. Simulation experiments demonstrate that biBLUP effectively captures two- and three-dimensional interaction effects underlying complex traits across diverse scenarios, resulting in a maximum increase of 62% in the predictive accuracy of the simulated complex traits. In a specific application on data consisted of 6,642 yeast lines, biBLUP successfully links complex phenotypes to biological pathways. By modeling the genetic interaction effects within the KEGG pathway associated with allantoin utilization, biBLUP achieves 40.36% improvement in accuracy for predicting the growth rate of yeast. Additionally, our study demonstrates that the incorporation of KEGG into biBLUP effectively captures the validated epistatic effects related to the flowering time of rice. This integration results in an improvement of 16.29% in the accuracy for predicting the flowering time of rice using biBLUP. In summary, this study enhances our understanding of the genetic architecture underlying complex traits and improves our ability to predict and study complex phenotypes more comprehensively.
Adsorption Performance of g-C3N4/graphene, and MIL-101(Fe)/graphene for the Removal of Pharmaceutical Contaminants: A Molecular Dynamics Simulation Study
Authors: Ibrahim Qusai , Gharbia Salem 
Published: April 2024

Abstract

The rising presence of drug-related contaminants in water sources is a major environmental and public health concern. Several studies have addressed the hazardous influence of these pollutants on the lives of over 400 million people worldwide. In this study, we used molecular dynamics simulations to evaluate the efficacy of two promising composite materials for the removal of pharmaceutical contaminants by using the adsorption technique. Graphitic carbon nitride/graphene (g-C3N4/graphene) and metal-organic framework (MIL-101(Fe))/graphene have been simulated for the first time for the removal of three of the most common pollutants (acetaminophen, caffeine, and sulfamethoxazole). The nanocomposite structure has been created and optimized using the geometry optimization task in the DFTB Modules in the Amsterdam Modeling Suite. Our results reveal the remarkable ability of the g-C3N4/graphene and MIL-101(Fe)/graphene composites to adsorb acetaminophen, caffeine, and sulfamethoxazole. Using the Reactive Forcefield (ReaxFF) software, we reveal the mechanisms of the adsorption process, calculating van der Waals interactions, and the adsorption capacity. We found that the combination of MIL-101(Fe)/graphene had a higher adsorption capacity for the removal of pharmaceutical contaminants than g-C3N4/graphene. At 40 Ps (Picosecond), 80 molecules of each pharmaceutical contaminants (Acetaminophen, Caffeine and Sulfamethoxazole) have been adsorbed by MIL-101(Fe)/graphene with higher exothermic energy equated to (-1174, -1630, and − 2347) MJ/mol respectively. While for g-C3N4/graphene at 40 Ps, 70 molecules of each pharmaceutical contaminants have been adsorbed with exothermic energy equated to (-924, -966, and − 1268) MJ/mol respectively. Finally, we summarized the condition of the essential parameters (Temperature, pressure, and density) of the simulation box during the MD-simulation, and the adsorption kinetics using Pseudo-First Order (PFO) in order to ensure the accuracy of our MD-simulation results.
Improving the Validity in Upper Limb Measurements for people with tetraplegia: An Investigation using Construct Specification Equations
Authors: Wangdell Johanna , Pendrill Leslie , Dunn Jennifer Anne , Hill Bridget , Melin Jeanette 
Published: April 2024

Abstract
The aim of this paper is two-fold: to investigate development of a CSE for UL task difficulty, 𝛿, and a CSE for person UL ability, 𝜃, in support of the validity of these two constructs. Measurements of UL task difficulty, 𝛿, and person UL ability, 𝜃were derived from applying the Rasch model on the Tetraplegia Upper Limb Activity Questionnaire (TUAQ). The formulations of CSEs as explanations of the two constructs were done using Principal Component Regression (PCR).
The CSE for UL task difficulty, 𝛿, was to a large degree explained by the number of joints involved with and the CSE for person UL ability, 𝜃, was dominated by grasp-related variables. Pearson coefficients of 0.94 and 0.73 were obtained between UL task difficulty and UL person ability from the CSE, respectively, when correlated with each empirical measure. The present work has both explored and extended the methodology for using more qualitative explanatory variables. Specifically, for UL measurements for people with tetraplegia a good CSE for task difficulty, 𝛿, supports the validity of TUAQ when measuring person UL ability. Additionally, the CSE formulated for person ability, 𝜃, can be used both for validation purposes as well as a clinical tool.
Research on gearbox bearing fault diagnosis based on SSA-VMD-CNN algorithms
Authors: Zhang Jianrui , Guo Jinchang , Geng Baolong , Song Haoyang , Zhang Yue , Zhao Rong 
Published: April 2024

Abstract

Gearbox bearings are crucial components in numerous mechanical systems. These gearboxes typically operate in environments characterized by significant noise, causing their fault signals to be obscured by background interference, vibrations, and signals from other mechanical parts. This interference complicates the accurate extraction and diagnosis of fault characteristics from complex data. To address this challenge, we propose a novel bearing fault diagnosis model that integrates Variational Mode Decomposition (VMD), Convolutional Neural Network (CNN), and advanced optimization algorithms. Initially, the Squirrel Search Algorithm (SSA) is employed to automatically optimize VMD parameters, enabling efficient extraction of denoised signal features. VMD decomposes vibration signals into multiple Intrinsic Mode Functions (IMFs), which are then analyzed and reconstructed using kurtosis and cross-correlation criteria. Subsequently, these processed signals serve as input feature vectors for the CNN model, facilitating both training and testing phases. The model is designed to construct a singular value vector matrix that reflects the current fault state based on the position of each submatrix. Simulation verification of our model demonstrates an accuracy exceeding 95% in bearing fault diagnosis, a substantial improvement over traditional methods. This advancement offers a new perspective for the health monitoring and maintenance of critical mechanical equipment, such as gearboxes. It holds significant potential for application in intelligent manufacturing and automated monitoring systems in the future.
High order invariant manifold model reduction for systems with non-polynomial non-linearities: geometrically exact finite-element structures and validity limit
Authors: GROLET Aurélien , Vizzaccaro Alessandra , Debeurre Marielle , Thomas Olivier 
Published: April 2024

Abstract

This paper considers the computation of reduced-order models for systems of ordinary differential equations that include non-polynomial non-linearities. An targeted example is the case of a geometrically exact model of highly flexible slender structure, that includes, after space discretisation, trigonometric non-linear terms. With a suitable change of variables, this system can be rewritten in an equivalent one with polynomial non-linearities at most quadratic, at the price of introducing additional variables linked to algebraic equations, leading to a differential algebraic set of equations (DAE) to be solved. This DAE is reduced thanks to a normal form parametrisation of its invariant manifolds and selecting a set of master ones.
Arbitrary order expansions are detailed for the coefficients of the change of variable and the reduced dynamics, using linear algebra in the space of multivariate polynomials of a given degree. In the case of a single non-linear mode reduction, a criterion to evaluate the quality of the normal form results is also proposed based on an estimation of the convergence radius of the polynomial asymptotic expansion representing truncated series. The method is then applied to compute a single mode reduction of three test cases -- a Duffing oscillator, a simple pendulum and a clamped clamped beam with von~K\'arm\'an model --, in order to investigate the effect of the algebraic part of the DAE on the quality of the model reduction and its validity range. Then, the more involved case of a cantilever beam modelled by geometrically exact finite elements is considered, underlining the ability of the method to produce accurate and converged results in a range of amplitude that can be bounded thanks to a convergence criterion.