bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Hydrophilic Metabolite UMP Alleviates Obesity Traits through a HIF2α‐ACER2‐Ceramide Signaling Axis
Authors: Liu Huiying , Wang Pengcheng , Xu Feng , Nie Qixing , Yan Sen , Zhang Zhipeng , Zhang Yi , Jiang Changtao , Qin Xiaomei , Pang Yanli 
Published: March 2024

AbstractMetabolic abnormalities contribute to the pathogenesis of obesity and its complications. Yet, the understanding of the interactions between critical metabolic pathways that underlie obesity remains to be improved, in part owing to the lack of comprehensive metabolomics studies that reconcile data from both hydrophilic and lipophilic metabolome analyses that can lead to the identification and characterization of key signaling networks. Here, the study conducts a comprehensive metabolomics analysis, surveying lipids and hydrophilic metabolites of the plasma and omental adipose tissue of obese individuals and the plasma and epididymal adipose tissue of mice. Through these approaches, it is found that a significant accumulation of ceramide due to inhibited sphingolipid catabolism, while a significant reduction in the levels of uridine monophosphate (UMP), is critical to pyrimidine biosynthesis. Further, it is found that UMP administration restores sphingolipid homeostasis and can reduce obesity in mice by reversing obesity‐induced inhibition of adipocyte hypoxia inducible factor 2a (Hif2α) and its target gene alkaline ceramidase 2 (Acer2), so as to promote ceramide catabolism and alleviate its accumulation within cells. Using adipose tissue Hif2α‐specific knockout mice, the study further demonstrates that the presence of UMP can alleviate obesity through a HIF2α‐ACER2‐ceramide pathway, which can be a new signaling axis for obesity improvement.
Harnessing Mechanical Stress with Viscoelastic Biomaterials for Periodontal Ligament Regeneration
Authors: Zhang Jiu‐Jiu , Li Xuan , Tian Yi , Zou Jie‐Kang , Gan Dian , Deng Dao‐Kun , Jiao Chen , Yin Yuan , Tian Bei‐Min , Wu Rui‐Xin , Chen Fa‐Ming , He Xiao‐Tao 
Published: March 2024

AbstractThe viscoelasticity of mechanically sensitive tissues such as periodontal ligaments (PDLs) is key in maintaining mechanical homeostasis. Unfortunately, PDLs easily lose viscoelasticity (e.g., stress relaxation) during periodontitis or dental trauma, which disrupt cell–extracellular matrix (ECM) interactions and accelerates tissue damage. Here, Pluronic F127 diacrylate (F127DA) hydrogels with PDL‐matched stress relaxation rates and high elastic moduli are developed. The hydrogel viscoelasticity is modulated without chemical cross‐linking by controlling precursor concentrations. Under cytomechanical loading, F127DA hydrogels with fast relaxation rates significantly improved the fibrogenic differentiation potential of PDL stem cells (PDLSCs), while cells cultured on F127DA hydrogels with various stress relaxation rates exhibited similar fibrogenic differentiation potentials with limited cell spreading and traction forces under static conditions. Mechanically, faster‐relaxing F127DA hydrogels leveraged cytomechanical loading to activate PDLSC mechanotransduction by upregulating integrin–focal adhesion kinase pathway and thus cytoskeletal rearrangement, reinforcing cell–ECM interactions. In vivo experiments confirm that faster‐relaxing F127DA hydrogels significantly promoted PDL repair and reduced abnormal healing (e.g., root resorption and ankyloses) in delayed replantation of avulsed teeth. This study firstly investigated how matrix nonlinear viscoelasticity influences the fibrogenesis of PDLSCs under mechanical stimuli, and it reveals the underlying mechanobiology, which suggests novel strategies for PDL regeneration.
5G NB‐IoT System Integrated with High‐Performance Fiber Sensor Inspired by Cirrus and Spider Structures
Authors: Lu Lijun , Hu Guosheng , Liu Jingquan , Yang Bin 
Published: March 2024

AbstractReal‐time telemedicine detection can solve the problem of the shortage of public medical resources caused by the coming aging society. However, the development of such an integrated monitoring system is hampered by the need for high‐performance sensors and the strict‐requirement of long‐distance signal transmission and reproduction. Here, a bionic crack‐spring fiber sensor (CSFS) inspired by spider leg and cirrus whiskers for stretchable and weavable electronics is reported. Trans‐scale conductive percolation networks of multilayer graphene around the surface of outer spring‐like Polyethylene terephthalate (PET) fibers and printing Ag enable a high sensitivity of 28475.6 and broad sensing range over 250%. The electromechanical changes in different stretching stages are simulated by Comsol to explain the response mechanism. The CSFS is incorporated into the fabric and realized the human‐machine interactions (HMIs) for robot control. Furthermore, the 5G Narrowband Internet of Things (NB‐IoT) system is developed for human healthcare data collection, transmission, and reproduction together with the integration of the CSFS, illustrating the huge potential of the approach in human–machine communication interfaces and intelligent telemedicine rehabilitation and diagnosis monitoring.
Biomimetic Self‐Propelled Asymmetric Nanomotors for Cascade‐Targeted Treatment of Neurological Inflammation
Authors: Ye Jiamin , Fan Yueyue , She Yaoguang , Shi Jiacheng , Yang Yiwen , Yuan Xue , Li Ruiyan , Han Jingwen , Liu Luntao , Kang Yong , Ji Xiaoyuan 
Published: March 2024

AbstractThe precise targeted delivery of therapeutic agents to deep regions of the brain is crucial for the effective treatment of various neurological diseases. However, achieving this goal is challenging due to the presence of the blood‒brain barrier (BBB) and the complex anatomy of the brain. Here, a biomimetic self‐propelled nanomotor with cascade targeting capacity is developed for the treatment of neurological inflammatory diseases. The self‐propelled nanomotors are designed with biomimetic asymmetric structures with a mesoporous SiO2 head and multiple MnO2 tentacles. Macrophage membrane biomimetic modification endows nanomotors with inflammatory targeting and BBB penetration abilities The MnO2 agents catalyze the degradation of H2O2 into O2, not only by reducing brain inflammation but also by providing the driving force for deep brain penetration. Additionally, the mesoporous SiO2 head is loaded with curcumin, which actively regulates macrophage polarization from the M1 to the M2 phenotype. All in vitro cell, organoid model, and in vivo animal experiments confirmed the effectiveness of the biomimetic self‐propelled nanomotors in precise targeting, deep brain penetration, anti‐inflammatory, and nervous system function maintenance. Therefore, this study introduces a platform of biomimetic self‐propelled nanomotors with inflammation targeting ability and active deep penetration for the treatment of neurological inflammation diseases.
High‐Valent Copper Catalysis Enables Regioselective Fluoroarylation of Gem‐Difluorinated Cyclopropanes
Authors: Wu Xiuli , Song Xiangyu , Xia Ying 
Published: March 2024

AbstractTransition‐metal (TM) catalyzed reaction of gem‐difluorinated cyclopropanes (gem‐DFCPs) has drawn much attention recently. The reaction generally occurs via the activation of the distal C─C bond in gem‐DFCPs by a low‐valent TM through oxidative addition, eventually producing mono‐fluoro olefins as the coupling products. However, achieving regioselective activation of the proximal C─C bond in gem‐DFCPs that overcomes the intrinsic reactivity via TM catalysis remains elusive. Here, a new reaction mode of gem‐DFCPs enabled by high‐valent copper catalysis, which allows exclusive activation of the congested proximal C─C bond is presented. The reaction that achieves fluoroarylation of gem‐DFCPs uses NFSI (N‐fluorobenzenesulfonimide) as electrophilic fluoro reagent and arenes as the C─H nucleophiles, enabling the synthesis of diverse CF3‐containing scaffolds. It is proposed that a high‐valent copper species plays an important role in the regioselective activation of the proximal C─C bond possibly via a σ‐bond metathesis.
Superatomic‐based chirality: Asymmetric structures constructed by superatoms
Authors: Yu Famin , Li Rui , Yang Xinrui , Shi Yulei , Wang Zhigang 
Published: March 2024

AbstractChirality is one of the fundamental properties of molecules traditionally constructed from atoms. Here, we report for the first time the successful construction of asymmetric chiral structures utilizing highly symmetric endohedral metallofullerene superatoms based on their own bonding properties. Specifically, stable mirror‐symmetric sinister and rectus structures are obtained by selecting a superatom capable of forming four chemical bonds as the chiral center. Further analysis shows that the chiral vibration frequency of superatomic assemblies can be as low as a few wavenumbers, which greatly expands the range of chiral spectra compared to atom‐based molecules. We term this type of chirality based on superatoms as “superatomic‐based chirality”. It is anticipated that this work will significantly expand the variety of chiral structures at the atomic level.
The relationship between mental well‐being and wealth varies by wealth type, place and sex/gender: Evidence from Namibia
Authors: Owens Caroline , Hadley Craig 
Published: March 2024

AbstractThis paper explores the impact of livelihood strategies and place on mental well‐being. Identifying different socioeconomic factors that impact mental well‐being across contexts is pressing given the global rise in mental health disorders. Numerous studies in the population and social sciences have emphasized the protective role of material wealth on human health and well‐being; however, scholars frequently assess wealth as a one‐dimensional variable, which may fail to capture diverse forms of wealth. Acknowledging different forms of wealth may be particularly important in settings where agricultural economies coexist with cash economies. Using data from the 2013 Namibia Demographic Health Survey (n = 13 377), we use a newly developed measure of success in agricultural activities, an agricultural wealth index, or AWI, generated by Hackman et al., (2021). To examine the role of different forms of wealth on mental health symptoms. We find mental well‐being, assessed through three survey questions, is lower among urban dwellers and females and shows varied associations with wealth type and sex/gender. In general, success in agricultural activities is associated with better mental well‐being, while the association with market success is null or and conditional upon sex/gender and place. This study adds to recent work on the value of using multidimensional measures of wealth and raises important questions about why wealth type and sex/gender differentially impact mental well‐being.
Work outcomes in public safety personnel after potentially traumatic events: A systematic review
Authors: Wagner Shannon L. , White Nicole , White Marc , Fyfe Trina , Matthews Lynda R. , Randall Christine , Regehr Cheryl , Alden Lynn E. , Buys Nicholas , Carey Mary G. , Corneil Wayne , Krutop Elyssa , Fraess‐Phillips Alex 
Published: March 2024

AbstractBackgroundIt is well documented that public safety personnel are exposed to potentially traumatic events (PTEs) at elevated frequency and demonstrate higher prevalence of trauma‐related symptoms compared to the general population. Lesser studied to date are the organizational consequences of workplace PTE exposure and associated mental health outcomes such as acute/posttraumatic stress disorder (ASD/PTSD), depression, and anxiety.MethodsThe present review synthesizes international literature on work outcomes in public safety personnel (PSP) to explore whether and how PTE and trauma‐related symptoms relate to workplace outcomes. A total of N = 55 eligible articles examining PTE or trauma‐related symptoms in relation to work outcomes were systematically reviewed using best‐evidence narrative synthesis.ResultsThree primary work outcomes emerged across the literature: absenteeism, productivity/performance, and costs to organization. Across n = 21 studies of absenteeism, there was strong evidence that PTE or trauma‐related symptoms are associated with increased sickness absence. N = 27 studies on productivity/performance demonstrated overall strong evidence of negative impacts in the workplace. N = 7 studies on cost to organizations demonstrated weak evidence that PTE exposure or trauma‐related mental health outcomes are associated with increased cost to organization.ConclusionsBased on available evidence, the experience of workplace PTE or trauma‐related symptoms is associated with negative impact on PSP occupational functioning, though important potential confounds (e.g., organizational strain and individual risk factors) remain to be more extensively investigated.
Megalencephaly secondary to a novel germline missense variant p.Asp322Tyr in AKT3 associated with growth hormone deficiency and central hypothyroidism: A case report
Authors: Renard E. , Bonnet C. , Di Patrizio M. , Schmitt E. , Madkaud A. C. , Chabot C. , Kuchenbuch M. , Lambert L. 
Published: March 2024

AbstractGermline gain of function variations in the AKT3 gene cause brain overgrowth syndrome with megalencephaly and diffuse bilateral cortical malformations. Here we report a child with megalencephaly, who is a carrier of a novel heterozygous missense variant in the AKT3 gene NM_005465.7:c.964G>T,p.Asp322Tyr. The phenotype of this patient is associated with pituitary deficiencies diagnosed at 2 years of age: growth hormone (GH) deficiency responsible for growth delay and central hypothyroidism. After 6 months of GH treatment, intracranial hypertension was noted, confirmed by the observation of papilledema and increased intracranial pressure, requiring the initiation of acetazolamide treatment and the discontinuation of GH treatment. This is the second reported patient described with megalencephaly and AKT3 gene variant associated with GH deficiency . Other endocrine disorders have also been reported in few cases with hypothyroidism and hypoglycemia. Pituitary deficiency may be a part of the of megalencephaly phenotype secondary to germline variant in the AKT3 gene. Special attention should be paid to growth in these patients and search for endocrine deficiency is necessary in case of growth retardation or hypoglycemia.
FOXG1 variants can be associated with milder phenotypes than congenital Rett syndrome with unassisted walking and language development
Authors: Mazel Benoit , Delanne Julian , Garde Aurore , Racine Caroline , Bruel Ange‐Line , Duffourd Yannis , Lopergolo Diego , Santorelli Filippo Maria , Marchi Viviana , Pinto Anna Maria , Mencarelli Maria Antonietta , Canitano Roberto , Valentino Floriana , Papa Filomena Tiziana , Fallerini Chiara , Mari Francesca , Renieri Alessandra , Munnich Arnold , Niclass Tanguy , Le Guyader Gwenaël , Thauvin‐Robinet Christel , Philippe Christophe , Faivre Laurence 
Published: March 2024

AbstractSince 2008, FOXG1 haploinsufficiency has been linked to a severe neurodevelopmental phenotype resembling Rett syndrome but with earlier onset. Most patients are unable to sit, walk, or speak. For years, FOXG1 sequencing was only prescribed in such severe cases, limiting insight into the full clinical spectrum associated with this gene. Next‐generation sequencing (NGS) now enables unbiased diagnostics. Through the European Reference Network for Rare Malformation Syndromes, Intellectual and Other Neurodevelopmental Disorders, we gathered data from patients with heterozygous FOXG1 variants presenting a mild phenotype, defined as able to speak and walk independently. We also reviewed data from three previously reported patients meeting our criteria. We identified five new patients with pathogenic FOXG1 missense variants, primarily in the forkhead domain, showing varying nonspecific intellectual disability and developmental delay. These features are not typical of congenital Rett syndrome and were rarely associated with microcephaly and epilepsy. Our findings are consistent with a previous genotype–phenotype analysis by Mitter et al. suggesting the delineation of five different FOXG1 genotype groups. Milder phenotypes were associated with missense variants in the forkhead domain. This information may facilitate prognostic assessments in children carrying a FOXG1 variant and improve the interpretation of new variants identified with genomic sequencing.
Genetic associations with dementia‐related proteinopathy: Application of item response theory
Authors: Katsumata Yuriko , Fardo David W. , Shade Lincoln M. P. , Wu Xian , Karanth Shama D. , Hohman Timothy J. , Schneider Julie A. , Bennett David A. , Farfel Jose M. , Gauthreaux Kathryn , Mock Charles , Kukull Walter A. , Abner Erin L. , Nelson Peter T. ,   The Alzheimer's Disease Neuroimaging Initiative,   The National Alzheimer's Coordinating Center
Published: March 2024

AbstractINTRODUCTIONAlthough dementia‐related proteinopathy has a strong negative impact on public health, and is highly heritable, understanding of the related genetic architecture is incomplete.METHODSWe applied multidimensional generalized partial credit modeling (GPCM) to test genetic associations with dementia‐related proteinopathies. Data were analyzed to identify candidate single nucleotide variants for the following proteinopathies: Aβ, tau, α‐synuclein, and TDP‐43.RESULTSFinal included data comprised 966 participants with neuropathologic and WGS data. Three continuous latent outcomes were constructed, corresponding to TDP‐43‐, Aβ/Tau‐, and α‐synuclein‐related neuropathology endophenotype scores. This approach helped validate known genotype/phenotype associations: for example, TMEM106B and GRN were risk alleles for TDP‐43 pathology; and GBA for α‐synuclein/Lewy bodies. Novel suggestive proteinopathy‐linked alleles were also discovered, including several (SDHAF1, TMEM68, and ARHGEF28) with colocalization analyses and/or high degrees of biologic credibility.DISCUSSIONA novel methodology using GPCM enabled insights into gene candidates for driving misfolded proteinopathies.Highlights
Latent factor scores for proteinopathies were estimated using a generalized partial credit model.
The three latent continuous scores corresponded well with proteinopathy severity.
Novel genes associated with proteinopathies were identified.
Several genes had high degrees of biologic credibility for dementia risk factors.
Promoting diverse perspectives: Addressing health disparities related to Alzheimer's and all dementias
Authors: Maestre Gladys , Hill Carl , Griffin Percy , Hall Stephen , Hu William , Flatt Jason , Babulal Ganesh , Thorpe Roland , Henderson J. Neil , Buchwald Dedra , Manson Spero , Cicero Ethan , Gilmore‐Bykovskyi Andrea , Gamaldo Alyssa , Glover Crystal , Barnes Lisa , Kind Amy , James Bryan , Zeki Al Hazzouri Adina , Wharton Whitney , Caramelli Paulo , Szanton Sarah , Whitmer Rachel , Benn Torres Jada , Deters Kacie , Okonkwo Ozioma , Das Rina , Martinez‐Gonzalez Karen , Carrillo Maria 
Published: March 2024

AbstractDementia research lacks appropriate representation of diverse groups who often face substantial adversity and greater risk of dementia. Current research participants are primarily well‐resourced, non‐Hispanic White, cisgender adults who live close to academic medical centers where much of the research is based. Consequently, the field faces a knowledge gap about Alzheimer's‐related risk factors in those other groups. The Alzheimer's Association hosted a virtual conference on June 14–16, 2021, supported in part by the National Institute on Aging (R13 AG072859‐01), focused on health disparities. The conference was held entirely online and consisted of 2 days of core programming and a day of focused meetings centered on American Indian and Alaska Natives and on LGBTQIA+ populations. Over 1300 registrants attended discussions focused on the structural and systemic inequities experienced across diverse groups, as well as ways to investigate and address these inequities.
The Propagation Dynamics of the Symmetric Pearcey Gaussian Beam in the Kerr Medium
Authors: Yu Peixin , Yang Shuo , Li Shuyu , Zhang Xiao , Man Zhongsheng , Ge Xiaolu , Zhang Wenfei , Chen Chidao , Deng Dongmei , Zhang Liping 
Published: March 2024

AbstractIn this paper, symmetric Pearcey Gaussian beams (SPGBs) are studied in a Kerr medium. By varying the initial input power, the autofocusing ability of the beams is investigated, to find a clear restrictive relationship between the breath‐like structure and the initial input power. The critical collapse power is investigated when SPGBs change from discrete beams to regular breath‐like structure. Finally, the transmission of SPGBs is discussed under different phase modulation when SPGBs are affected by astigmatic, the whole beam is rotated and the angle of rotation can be controlled.
High‐Precision Viral Detection Using Electrochemical Kinetic Profiling of Aptamer‐Antigen Recognition in Clinical Samples and Machine Learning
Authors: Sen Payel , Zhang Zijie , Sakib Sadman , Gu Jimmy , Li Wantong , Adhikari Bal Ram , Motsenyat Ariel , L'Heureux‐Hache Jonathan , Ang Jann C. , Panesar Gurpreet , Salena Bruno J. , Yamamura Debora , Miller Matthew S. , Li Yingfu , Soleymani Leyla 
Published: March 2024

AbstractHigh‐precision viral detection at point of need with clinical samples plays a pivotal role in the diagnosis of infectious diseases and the control of a global pandemic. However, the complexity of clinical samples that often contain very low viral concentrations makes it a huge challenge to develop simple diagnostic devices that do not require any sample processing and yet are capable of meeting performance metrics such as very high sensitivity and specificity. Herein we describe a new single‐pot and single‐step electrochemical method that uses real‐time kinetic profiling of the interaction between a high‐affinity aptamer and an antigen on a viral surface. This method generates many data points per sample, which when combined with machine learning, can deliver highly accurate test results in a short testing time. We demonstrate this concept using both SARS‐CoV‐2 and Influenza A viruses as model viruses with specifically engineered high‐affinity aptamers. Utilizing this technique to diagnose COVID‐19 with 37 real human saliva samples results in a sensitivity and specificity of both 100 % (27 true negatives and 10 true positives, with 0 false negative and 0 false positive), which showcases the superb diagnostic precision of this method.
Appending Coronene Diimide with Carbon Nanohoops Allows for Rapid Intersystem Crossing in Neat Film
Authors: Zhao Jingjing , Xu Jingwen , Huang Huaxi , Wang Kangwei , Wu Di , Jasti Ramesh , Xia Jianlong 
Published: March 2024

AbstractThe development of innovative triplet materials plays a significant role in various applications. Although effective tuning of triplet formation by intersystem crossing (ISC) has been well established in solution, the modulation of ISC processes in the solid state remains a challenge due to the presence of other exciton decay channels through intermolecular interactions. The cyclic structure of cycloparaphenylenes (CPPs) offers a unique platform to tune the intermolecular packing, which leads to controllable exciton dynamics in the solid state. Herein, by integrating an electron deficient coronene diimide (CDI) unit into the CPP framework, a donor‐acceptor type of conjugated macrocycle (CDI‐CPP) featuring intramolecular charge‐transfer (CT) interaction was designed and synthesized. Effective intermolecular CT interaction resulting from a slipped herringbone packing was confirmed by X‐ray crystallography. Transient spectroscopy studies showed that CDI‐CPP undergoes ISC in both solution and the film state, with triplet generation time constants of 4.5 ns and 238 ps, respectively. The rapid triplet formation through ISC in the film state can be ascribed to the cooperation between intra‐ and intermolecular charge‐transfer interactions. Our results highlight that intermolecular CT interaction has a pronounced effect on the ISC process in the solid state, and shed light on the use of the characteristic structure of CPPs to manipulate intermolecular CT interactions.