bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on physical and mechanical properties of cement asphalt emulsified mortar under track slab
Authors: Wang Tao , Wu Shaoliang , Jia Hengqiong , Peng Shanqing , Li Haiyan , Shao Piyan , Wei Zhao , Shi Yi 
Published: March 2024

PurposeDuring the construction process of the China Railway Track System (CRTS) I type filling layer, the nonwoven fabric bags have been used as grouting templates for cement asphalt (CA) emulsified mortar. The porous structure of nonwoven fabrics endowed the templates with breathability and water permeability. The standard requires that the volume expansion rate of CA mortar must be controlled within 1%–3%, which can generate expansion pressure to ensure that the cavities under track slabs are filled fully. However, the expansion pressure caused some of the water to seep out from the periphery of the filling bag, and it would affect the actual mix proportion of CA mortar. The differences in physical and mechanical properties between the CA mortar under track slabs and the CA mortar formed in the laboratory were studied in this paper. The relevant results could provide important methods for the research of filling layer materials for CRTS I type and other types of ballastless tracks in China.Design/methodology/approachDuring the inspection of filling layer, the samples of CA mortar from different working conditions and raw materials were taken by uncovering the track slabs and drilling cores. The physical and mechanical properties of CA mortar under the filling layer of the slab were systematically analyzed by testing the electrical flux, compressive strength and density of mortar in different parts of the filling layer.FindingsIn this paper, the electric flux, the physical properties and mechanical properties of different parts of CA mortar under the track slab were investigated. The results showed that the density, electric flux and compressive strength of CA mortar were affected by the composition of raw materials for dry powders and different parts of the filling layer. In addition, the electrical flux of CA mortar gradually decreased within 90 days’ age. The electrical flux of samples with the thickness of 54 mm was lower than 500 C. Therefore, the impermeability and durability of CA mortar could be improved by increasing the thickness of filling layer. Besides, the results showed that the compressive strength of CA mortar increased, while the density and electric flux decreased gradually, with the prolongation of hardening time.Originality/valueDuring 90 days' age, the electrical flux of the CA mortar gradually decreased with the increase of specimen thickness and the electrical flux of the specimens with the thickness of 54 mm was lower than 500 C. The impermeability and durability of the CA mortar could be improved by increasing the thickness of filling layer. The proposed method can provide reference for the further development and improvement of CRTS I and CRTS II type ballastless track in China.
To(o) Queer the Analyst: Lesbiana, Junguiana and Sudamericana. Towards Woven Onto‐Epistemologies1
Authors: Kierbel Valeria 
Published: March 2024

AbstractThis is a two‐part paper: in the first one, a personal story serves as a conceptual prism through which I address the issue of how a queer analyst can be a problem for analytical psychology; in the second, I present some readings and images—mostly from decolonial feminisms—that have been of interest to me lately in my path to queer Jungian psychology, that is, to de‐essentialize and de‐individualize its theory and practice. By borrowing (and altering) the title from Gloria Anzaldúa's (1991/2009a) essay “To(o) queer the writer”, this paper explores some themes she has elaborated there on solidarity, theorization and ways of writing and reading from othered points of view. In dialogue with Donna Haraway's (2016) Staying with the Trouble and Ursula K. Le Guin's (1989/2000) The Carrier Bag Theory of Fiction, together with the imagery of bags, weaving and string figures game, this paper aims to explore the potential of what I have called “woven onto‐epistemologies”. By imagining and developing this new condition of knowledge, other stories and theories in analytical psychology may have an opportunity to be told.
Immunological regulation and the role of autophagy in preeclampsia
Authors: Nakashima Akitoshi , Furuta Atsushi , Yoshida‐Kawaguchi Mihoko , Yamada Kiyotaka , Nunomura Haruka , Morita Keiko , Yasuda Ippei , Yoneda Satoshi , Yamaki‐Ushijima Akemi , Shima Tomoko , Tsuda Sayaka 
Published: March 2024

AbstractAutophagy is a bulk degradation system that maintains cellular homeostasis by producing energy and/or recycling excess proteins. During early placentation, extravillous trophoblasts invade the decidua and uterine myometrium, facing maternal immune cells, which participate in the immune suppression of paternal and fetal antigens. Regulatory T cells will likely increase in response to a specific antigen before and during early pregnancy. Insufficient expansion of antigen‐specific Treg cells, which possess the same T cell receptor, is associated with the pathophysiology of preeclampsia, suggesting sterile systemic inflammation. Autophagy is involved in reducing inflammation through the degradation of inflammasomes and in the differentiation and function of regulatory T cells. Autophagy dysregulation induces protein aggregation in trophoblasts, resulting in placental dysfunction. In this review, we discuss the role of regulatory T cells in normal pregnancies. In addition, we discuss the association between autophagy and regulatory T cells in the development of preeclampsia based on reports on the role of autophagy in autoimmune diseases.
Meeting the challenges of continuing education online courses: Can we promote self‐regulated learning strategies with adaptive support?
Authors: Teich Katharina , Loock Vanessa Stefanie , Rummel Nikol 
Published: March 2024

AbstractOnline courses are particularly attractive in continuing education because they offer a high degree of autonomy and flexibility, although this requires learners to take greater responsibility for self‐regulating their learning. That can be challenging for adult learners as they need to handle other obligations in addition to learning. Thus, self‐regulated learning (SRL) support might be needed. In the present study, we aimed to investigate how the specific SRL challenges that adult learners face in online courses can be supported adaptively. Main challenges for adult learners consist in managing learning resources (e.g., time, attention, learning environment). To address these challenges, we developed an adaptive support intervention comprising several features. To assess the effects of the adaptive support on the self‐reported SRL strategy application of adult learners, we analysed data from five iterations of a continuing education online course comparing iterations with adaptive support (with a total of N = 36 participants) to iterations without (with a total of N = 35 participants). Results indicate that the adaptive support significantly improved environmental structuring but did not significantly affect other SRL strategies. Further analyses revealed that learners who did not use the support deteriorated in managing their learning time and in setting specific learning goals during the course.
Practitioner notesWhat is already known about this topic

Adult learners are likely to face various challenges in self‐regulated online learning, including managing conflicting responsibilities and maintaining focus.
Adult learners' successful application of SRL strategies can be challenging, underlining the need for support.
Adaptive support interventions have demonstrated positive effects in various educational contexts, indicating potential effectiveness for adult online learners as well.
What this paper adds

The study provides insights into the positive effects and potential pitfalls of designing an adaptive support intervention to improve adult learners' self‐reported use of the SRL strategies of effort, attention, time management, environmental structuring, and goal setting.
Implications for practice and/or policy

The findings suggest that providing adaptive support, namely a structured course overview and adaptive recommendations of learning time and relevant content, can positively influence adult learners' environmental structuring.
Our findings also highlight the challenge of achieving optimal support design, as evidenced by low support use. This finding highlights the need to explore additional methods to motivate adult learners to use the support provided while carefully respecting their autonomy.
Use of once‐daily oral semaglutide and associated clinical outcomes among adults with type 2 diabetes in routine clinical practice in Canada: A multicentre, prospective real‐world study (PIONEER REAL Canada)
Authors: Jain Akshay B. , Reichert Sonja M. , Amadid Hanan , Braae Uffe C. , Bradley Ryan M. , Kim James W. , Soo Victoria , Yale Jean‐François 
Published: March 2024

AbstractAimPIONEER REAL Canada examined real‐world clinical outcomes associated with the use of once‐daily oral semaglutide in adults with type 2 diabetes.Materials and MethodsThis was a 34‐ to 44‐week, multicentre, prospective, open‐label, non‐interventional study in adults who were treatment‐naive to injectable glucose‐lowering medication and initiated oral semaglutide in routine clinical practice. The primary endpoint was the change in glycated haemoglobin (HbA1c) from baseline to the end of the study (EoS). Secondary endpoints assessed at EoS were change from baseline in body weight (BW); the proportion of participants reaching HbA1c levels <7% and the composite endpoints, HbA1c reduction ≥1% point with BW reduction ≥3% and ≥5%; and treatment satisfaction measured using Diabetes Treatment Satisfaction Questionnaires (DTSQ) status and change. Primary analyses were based on the in‐study observation period.ResultsIn total, 182 participants initiated oral semaglutide (mean age, 58.6 years; HbA1c, 8.0%; BW, 93.7 kg). The estimated changes (95% confidence interval) from baseline to EoS in HbA1c and BW were −1.09% points (−1.24, −0.94; p < .0001) and −7.17% (−8.24, −6.11; p < .0001), respectively. At EoS, 53.7% of participants had HbA1c levels <7%; 39.3% and 31.6% reached HbA1c reduction ≥1% point plus BW reduction ≥3% and ≥5%, respectively. Treatment satisfaction significantly increased (DTSQ status, +4.47 points; DTSQ change, 11.83 points; both p < .0001). At EoS, 75.3% of participants remained on oral semaglutide (55.5% received oral semaglutide 14 mg). No new safety signals were identified for oral semaglutide.ConclusionsIn PIONEER REAL Canada, participants treated with oral semaglutide in routine clinical practice experienced clinically relevant reductions in HbA1c and BW and increased treatment satisfaction.
MyD88‐mediated signaling is critical for the generation of seizure responses and cognitive impairment in a model of anti‐N‐methyl‐D‐aspartate receptor encephalitis
Authors: Taraschenko Olga , Fox Howard S. , Eldridge Ember , Heliso Priscilla , Al‐Saleem Fetweh , Dessain Scott , Casale George , Willcockson Gregory , Anderson Kayley , Wang Wenyi , Dingledine Raymond 
Published: March 2024

AbstractObjectiveWe previously demonstrated that interleukin‐1 receptor‐mediated immune activation contributes to seizure severity and memory loss in anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis. In the present study, we assessed the role of the myeloid differentiation primary response gene 88 (MyD88), an adaptor protein in Toll‐like receptor signaling, in the key phenotypic characteristics of anti‐NMDAR encephalitis.MethodsMonoclonal anti‐NMDAR antibodies or control antibodies were infused into the lateral ventricle of MyD88 knockout mice (MyD88−/−) and control C56BL/6J mice (wild type [WT]) via osmotic minipumps for 2 weeks. Seizure responses were measured by electroencephalography. Upon completion of the infusion, the motor, anxiety, and memory functions of the mice were assessed. Astrocytic (glial fibrillary acidic protein [GFAP]) and microglial (ionized calcium‐binding adaptor molecule 1 [Iba‐1]) activation and transcriptional activation for the principal inflammatory mediators involved in seizures were determined using immunohistochemistry and quantitative real‐time polymerase chain reaction, respectively.ResultsAs shown before, 80% of WT mice infused with anti‐NMDAR antibodies (n = 10) developed seizures (median = 11, interquartile range [IQR] = 3–25 in 2 weeks). In contrast, only three of 14 MyD88−/− mice (21.4%) had seizures (0, IQR = 0–.25, p = .01). The WT mice treated with antibodies also developed memory loss in the novel object recognition test, whereas such memory deficits were not apparent in MyD88−/− mice treated with anti‐NMDAR antibodies (p = .03) or control antibodies (p = .04). Furthermore, in contrast to the WT mice exposed to anti‐NMDAR antibodies, the MyD88−/− mice had a significantly lower induction of chemokine (C‐C motif) ligand 2 (CCL2) in the hippocampus (p = .0001, Sidak tests). There were no significant changes in the expression of GFAP and Iba‐1 in the MyD88−/− mice treated with anti‐NMDAR or control antibodies.SignificanceThese findings suggest that MyD88‐mediated signaling contributes to the seizure and memory phenotype in anti‐NMDAR encephalitis and that CCL2 activation may participate in the expression of these features. The removal of MyD88 inflammation may be protective and therapeutically relevant.
CLASS AND CLASS CONSCIOUSNESS ACCORDING TO E. P. THOMPSON
Authors: Cunningham Daniel 
Published: March 2024

ABSTRACTIn this article, I extract a theory of class from E. P. Thompson's historical works of the 1960s and 1970s, focusing especially on his 1963 magnum opus The Making of the English Working Class, the articles later collected in the 1991 volume Customs in Common: Studies in Traditional Popular Culture, and the essays “The Peculiarities of the English” and “Eighteenth‐Century English Society: Class Struggle without Class?” In the first section, I argue, following Ellen Meiksins Wood, that Thompson developed a genuinely historical materialist theory of class formation as a “structured process” that moves from class struggle to class consciousness, a theory that complicates the frequent description of Thompson as a “voluntarist.” In the second section, I take a more critical position toward Thompson's understanding of class, discussing a tension between this notion of class as structured process and his numerous invocations of class as a form of “lived experience” whose diversity and unpredictability exceed theorization. This tension aside, Thompson claims that, in the case of the nineteenth‐century English working class, to which he dedicated so much research, lived experience coincided with the more general structured process he posits. In the third section, therefore, I more fully elaborate on this specific process of class formation as Thompson portrays it, identifying and discussing three intertwined threads: (1) a movement from a past‐oriented defense of traditional institutions to a future‐oriented demand for reforms, (2) the development of oppositional, class‐specific pedagogical institutions and practices, and (3) the creation of a distinct class culture (which Thompson closely aligns with the achievement of class consciousness) that is aware both of itself and of its antagonism with other classes.
UNCERTAINTY, LONG‐RUN, AND MONETARY POLICY RISKS IN A TWO‐COUNTRY MACRO MODEL
Authors: Berg Kimberly A. , Mark Nelson C. 
Published: March 2024

AbstractWe study the currency risk premium and the forward premium bias in a two‐country New Keynesian model with production, no physical capital, and recursive utility. Monetary policy follows an interest rate feedback rule and exogenous total factor productivity (TFP) growth follows a long‐run risk process with stochastic volatility, which we estimate from data. With cross‐country heterogeneity in TFP and monetary policy, reasonable currency risk premia emerge under complete and incomplete markets but the forward premium bias is trivial. We diagnose the challenge faced by this fairly standard production model to explain the forward premium bias.
Effect of the hydrotalcite formation on the fracture behavior and corrosion resistance of HA‐bonded alumina‐spinel castables
Authors: Xu Suchen , Liu Wenjing , Liao Ning , Nath Mithun , Li Yawei 
Published: March 2024

AbstractHydratable alumina‐bonded castable is a promising non‐cement bonded refractory for ladle lining. An in situ formation of layered double hydroxides (Mg–Al hydrotalcite, M–A–H) using reactive MgO powders is proposed as a means of enhancing the castables during curing, drying, and after the high‐temperature treatment. The formation of hydrotalcite, spinel transformation, pore structure, mechanical properties, fracture behavior, and slag corrosion resistance have been systematically investigated. The results indicate that the hydrotalcite formation is governed by the hydration reactivity of MgO, which promotes the formation of Mg(OH)2 as an intermediate hydrate, and the ultimate growth of hydrotalcite. The residual MgO and newly formed hydrotalcite are eventually transformed into micron size and submicron size spinel, respectively. This structural evolution contributes to an optimized pore structure and microstructure, enhancing the castables. The ultimate pore structure and enhanced interfaces between aggregate and matrix facilitate the improvement of toughness and slag corrosion/penetration resistance.
A device‐related fistula between coronary artery and left atrial appendage following left atrial appendage closure: Case presentation
Authors: Liu Xiaohua , Xu Yizhou 
Published: March 2024

AbstractIntroductionLeft atrial appendage (LAA) closure (LAAC) is considered a viable alternative to anticoagulation therapy for stroke prevention in nonvalvular atrial fibrillation, we report a case with a less common shunt resulting from a device‐related coronary artery‐appendage fistula (CAAF) following LAAC.Methods and ResultsA 67‐year‐old male with a history of LAAC was referred to our emergency room with recurrent chest pain and palpitations and was diagnosed with ischemic angina pectoris. Subsequent coronary angiography (CAG) revealed 70% in‐stent restenosis and an abnormal shunt of contrast originating from the left circumflex artery (LCA) to the LAA tip which did not exist before. The restenosis was successfully dilated using a drug‐coated balloon, the procedure was safely completed without pericardial effusion. The patient had been implanted with a LAmbre occluder (Lifetech Scientific Corp.) in the previous LAAC procedure. This occluder had a lobe‐disk design, and the distal umbrella was not fully opened after release, particularly in the lower portion. This could make the hooks embedded on the umbrella contact the LAA wall more tightly, possibly resulting in microperforation and coincidental impingement of the LCA. The epicardial adipose and hyperplastic tissue then chronically wrapped the perforated site, prevented blood outflow into the epicardium, and ultimately formed a CAAF.ConclusionCAAF is a rare complication after LAAC but may be underestimated, especially for lobe‐disk designed occluders. Therefore, CAG is perhaps necessary to detect this complication.
Effect of non‐surgical periodontal therapy on salivary histone deacetylases expression: A prospective clinical study
Authors: Liaw Andrew , Liu Chun , Bartold Mark , Ivanovski Sašo , Han Pingping 
Published: March 2024

AbstractAimTo evaluate the effect of non‐surgical periodontal therapy (NSPT) on salivary histone deacetylases (HDACs) gene expression in patients with Stage III–IV periodontitis at baseline and at 3 and 6 months post NSPT treatment.Materials and MethodsTwenty patients completed the study. Periodontitis (as well as the corresponding staging and grading) was diagnosed according to the 2017 World Workshop Classification. Clinical measures were recorded and whole unstimulated saliva was collected at baseline and at 3 and 6 months after NSPT. The expression of 11 HDACs was determined using reverse‐transcription PCR, and the respective changes over time were evaluated.ResultsSix months after NSPT, significant improvements in all clinical periodontal parameters were observed, concomitant with significant up‐regulation of HDAC2, 4, 6, 8, 9 and 11 expressions. Subgroup analyses of non‐responders and responders revealed no significant differences in HDACs mRNA expression between groups at any time point.ConclusionsThis prospective clinical study identified longitudinal changes in salivary HDACs expression in response to NSPT, which provides new insights into the epigenetic mechanisms underlying the pathobiology of periodontitis and creates avenues for the discovery of novel biomarkers.
Docudrama and the Agential Child: Treading a Path Between Melodrama and National Geographic
Authors: Wells Karen 
Published: March 2024

AbstractThis paper describes the making of a documentary film about children's learning cultures in West Africa to show that it is possible to escape the melodramatic gaze through deploying specific shooting, editorial and screening choices that represent children as active, knowledgeable subjects situated in a specific cultural milieu. It also discusses the legacy of ethnographic film, especially in relation to Africa, which in its aim at cultural translation presumes a non‐local spectator and deploys what has been called an entomological gaze; glossed here as ‘national geographic’ and proposes that key to disavowing that legacy is making film for African audiences.
Reference values and reliability of occlusal force distribution and occlusal time measured by the T‐Scan system in adults with healthy dentition
Authors: Rubió‐Ferrer Gemma , Rovira‐Lastra Bernat , Khoury‐Ribas Laura , Flores‐Orozco Elan Ignacio , Ayuso‐Montero Raul , Martinez‐Gomis Jordi 
Published: March 2024

AbstractPurposeReference values of occlusal characteristics are needed to interpret the data obtained using the T‐Scan System. This study aimed to establish reference values for and to assess the reliability of, occlusal force distribution in the maximal intercuspal position and the occlusion time in young adults with healthy dentition.Materials and MethodsIn total 178 adults with natural dentition participated in this retrospective cross‐sectional study, of whom 76 performed a retest session. Several occlusal recordings were obtained from each participant using the T‐Scan system while asking them to bite two or three consecutive times (multi‐bite) or only once (single‐bite) at the maximal intercuspal position. The lateral and anteroposterior occlusal force distribution were determined as percentages in the right and posterior teeth . Occlusion time was measured in seconds. After the occlusal force distribution and occlusion time percentiles were calculated, reliability was assessed by the intraclass correlation coefficient.ResultsThe 5th–95th percentiles for occlusal force distribution were 34%–67% on the right teeth and 55%–94% on the posterior teeth. The 90th percentile for multi‐bite occlusion time was 0.17 s and for single‐bite occlusion time was 0.27 s. The intraclass correlation coefficients for lateral occlusal force distribution, anteroposterior occlusal force distribution, multi‐bite occlusion time, and single‐bite occlusion time were 0.70, 0.68, 0.58, and 0.67, respectively.ConclusionsThis study generated reference values for key occlusal characteristics (occlusal force distribution and occlusion time) when using the T‐Scan system. These values showed moderate reliability.