bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatty Acid Intake and Polyunsaturated Fatty Acid Biomarkers and Risk of Total Knee or Hip Arthroplasty Among Older Women in the Women's Health Initiative
Authors: Orchard Tonya , McLaughlin Eric , Winschel Timothy , Shadyab Aladdin , Laddu Deepika , Vitolins Mara , Constantinescu Florina , Jackson Rebecca 
Published: February 2024

ObjectiveThe objective was to determine whether baseline fatty acid intake and erythrocyte omega‐3 and omega‐6 polyunsaturated fatty acids (PUFAs) can predict risk of total hip arthroplasty (THA) and total knee arthroplasty (TKA) in older women.MethodsThis was a prospective analysis of 34,990 women in the Women's Health Initiative. Dietary fatty acids were estimated from food frequency questionnaires. Imputed erythrocyte PUFAs were available in a subcohort of 3,428 women. Arthroplasty (THA and TKA), used as a surrogate of severe osteoarthritis, was identified via linked Medicare data. Cox proportional hazards models were constructed to estimate risk of arthroplasty.ResultsRisk of THA was associated with higher intake of arachidonic acid, (multivariable hazard ratio [HR] quartile 4 [Q4] vs Q1: 1.16; 95% confidence interval [CI] 1.01–1.34; P = 0.03) and higher intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA; HR Q4 vs Q1: 1.20; 95% CI 1.05–1.39; P = 0.003). There was a linear trend (P = 0.04) for patients to have a higher risk of THA with higher erythrocyte EPA and DHA in body mass index–adjusted models; however, there was no significant difference in patients who had THAs by quartiles of erythrocyte EPA and DHA (P = 0.10). Dietary fatty acids and erythrocyte PUFAs were not significantly associated with risk of TKA.ConclusionHigher baseline intakes of arachidonic acid and EPA and DHA were associated with a modestly higher risk of THA. No association was found between fatty acids and patients who had TKAs. Further research in populations with direct measures of osteoarthritis severity is needed to better understand the importance of PUFAs in modulating osteoarthritis and arthroplasty risk.
Multi‐model predictive control of converter inlet temperature in the process of acid production with flue gas
Authors: Liu Minghua , Li Xiaoli , Wang Kang , Liu Zhiqiang , Li Guihai 
Published: February 2024

SummaryThe smelting of non‐ferrous metals produces substantial quantities of sulfur dioxide (SO)‐laden flue gas, which is seriously harmful to environment and humans. To improve the conversion ratio of SO and minimize environmental pollution, controlling converter inlet temperature during acid production has proven to be an efficient approach. However, unsteadiness of smelting procedure leads to frequent changes in the concentration of SO, which affects the catalytic conversion of SO and the production of sulfuric acid. To regulate converter inlet temperature, a proposed method of multi‐model predictive control is introduced. First, working conditions are divided and characterized according to the range of SO concentration. Then, the mathematical model is established for each working condition and the model predictive controller is designed. Finally, an effective switching mechanism is established to realize smooth switching under different working conditions and closed‐loop control of the whole system. Through simulation validation, compared with traditional single‐model predictive controllers and multi‐model PID controllers, the proposed approach demonstrates improved transient performance and steady‐state performance. Simulation outcomes clearly highlight the superiority of the proposed algorithm.
Endoplasmic Reticulum‐Targeting Iridium(III) Nanosonosensitizer Amplifies Immunogenic Cell Death for Boosted Tumor Sono‐Immunotherapy
Authors: Xu Xiaoyu , Chen Meixu , Jiang Shan , Pan Zhengyin , Zhao Chunshun 
Published: February 2024

AbstractReactive oxygen species (ROS)‐induced endoplasmic reticulum (ER) stress in sonodynamic therapy (SDT) can elicit immunogenic cell death (ICD)‐initiated antitumor immunity for augmented sono‐immunotherapy. However, unsatisfactory sonodynamic activity and mediocre ER stress induction ability of sonosensitizers essentially restrict SDT efficacy and ICD stimulation. Herein, a versatile ER‐targeting Iridium(III) nanosonosensitizer is developed as superior ICD inducer for boosted tumor sono‐immunotherapy. An ingenious cholic acid (CA)‐functionalized Iridium(III) sonosensitizer Ir‐CA is well‐designed and skillfully crosslinked with human serum albumin (HSA) to form nanosonosensitizer HSA@Ir‐CA. With high stability, favorable tumor‐targeting ability, and reduction‐responsiveness, HSA@Ir‐CA preferentially accumulates in tumor sites for enhanced cellular uptake, followed by rapid disassembly responding to intracellular reductive environment. The uncaged Ir‐CA can selectively accumulate in ER and precisely disrupt ER with in situ produced type I and II ROS upon US irradiation for a high‐efficiency SDT. Moreover, the maximized ER stress eminently amplifies ICD to evoke robust systemic antitumor immunity, inhibiting the growths of primary/distant tumor, lung metastasis, and tumor recurrence. This ER‐targeting SDT combined with immune checkpoint inhibitor (αPD‐L1) further achieves reinforced therapeutic outcome against immunologically “cold” tumor. The study presents an effective paradigm to optimize SDT efficacy and amplify ICD‐initiated immune responses for boosted sono‐immunotherapy.
Acupoint Therapy with Injectable, Pro‐Healing Stem Cell‐Loaded Hydrogel Microspheres Promotes Skin Wound Healing
Authors: Yan Yinqiu , Chen Liling , Zheng Liwen , Wang Gen , Zhang Hongmei , Feng Xing , Liu Yaxian , Li Lan , Zhang Yu Shrike , Ji Ping , Zhang Ximu 
Published: February 2024

AbstractWound repair is a complex and dynamic process, involving stages of hemostasis, inflammation, proliferation, and remodeling. Standard methods currently used for clinical treatment of skin defects remain unsatisfying and alternative treatments have emerged including acupuncture mostly relying on the conventional needle method. It is applied sustained acupuncture therapy with bioengineered stem cell‐loaded hydrogel microspheres (A‐SGC), where the data gathered through transcriptomics, metabolomics, and single‐cell omics analyses are used to construct a comprehensive multi‐omics map underlying the wound regeneration process with such a therapy. Under the treatment of A‐SGC, the interactions and Yin‐Yang balance among fibroblasts, macrophages, endothelial cells, and keratinocytes facilitated skin regeneration instead of scarred healing. The genes related to the promotion of matrix synthesis and re‐epithelialization played important roles in the transition from the inflammatory granulation phase to the stromal remodeling phase. This convergence use of hydrogel microspheres, stem cells, and sustained acupuncture therapy could have previously unattainable therapeutic implications for improved wound treatment.
Quasi‐MOF‐Engineered MnOx/CeBTC Multinanozyme as a Robust Self‐Cascade ROS Generator toward Antibacterial Face Mask
Authors: Meng Yuqi , Han Ruiting , Tian Qing , Chen Yao , Zhang Lianbing 
Published: February 2024

AbstractIt is of great importance to endow personal protective equipments with bactericidal property combating against infected pathogens. Nanozyme that can generate reactive oxygen species (ROS) in an enzyme‐catalytic manner is regarded as a novel and promising nanobactericide. But until now, very rare of them is designed specifically for personal protective equipments. In this study, a multinanozyme of manganese oxide supported on Ce‐containing MOF (CeBTC) is constructed with post‐engineering via a quasi‐metal‐organic framework (MOF) strategy (denoted as MnOx/q‐CeBTC). The strategy enables a full exposure of the metal cluster nodes, introduction of new active Mn─O─Ce bonds and strengthens interaction between the metal nodes and the guest oxide. As an advanced multinanozyme, the MnOx/q‐CeBTC exhibits excellent multiple enzymatic activities at low temperature, and enables abundant and self‐cascade ROS generation without H2O2 addition. This empowers it with high efficiency in bacteria killing, which is also reflected when incorporated into face mask to combat against pathogen invasion even at low temperature. The results achieved in this work provide guidance for rational design of effective bactericide based on nanozyme and broaden their application in personal protective equipment and other fields.
Truly Tiny Acoustic Biomolecules for Ultrasound Imaging and Therapy
Authors: Ling Bill , Gungoren Bilge , Yao Yuxing , Dutka Przemysław , Vassallo Reid , Nayak Rohit , Smith Cameron A. B. , Lee Justin , Swift Margaret B. , Shapiro Mikhail G. 
Published: February 2024

AbstractNanotechnology offers significant advantages for medical imaging and therapy, including enhanced contrast and precision targeting. However, integrating these benefits into ultrasonography is challenging due to the size and stability constraints of conventional bubble‐based agents. Here bicones, truly tiny acoustic contrast agents based on gas vesicles (GVs), a unique class of air‐filled protein nanostructures naturally produced in buoyant microbes, are described. It is shown that these sub‐80 nm particles can be effectively detected both in vitro and in vivo, infiltrate tumors via leaky vasculature, deliver potent mechanical effects through ultrasound‐induced inertial cavitation, and are easily engineered for molecular targeting, prolonged circulation time, and payload conjugation.
Cable Cross‐Tie Triboelectric‐Electromagnetic Hybrid Generator Triggered by Vibrations in Bridge Cables
Authors: Guo Xilin , Liu Shiming , Zhang Tao , Zhu Zhaobin , Meng Lixia 
Published: February 2024

AbstractBridge cables exhibit low damping characteristics and are susceptible to external excitations, leading to random vibrations. Therefore, a cable cross‐tie triboelectric‐electromagnetic hybrid generator triggered by vibrations in bridge cables (CCT‐TEHG) is proposed. The CCT‐TEHG enhances the natural frequency of the cables by connecting adjacent cables, thereby preventing low‐frequency resonance. The device connects adjacent bridge cables to increase the natural frequency, preventing low‐frequency resonance. Comprising triboelectric nanogenerators (TENGs) and electromagnetic generators (EMG), the CCT‐TEHG effectively broadens the frequency range for energy harvesting, capturing vibrational energy from bridge cables in cable‐stayed bridges. The TENG module in CCT‐TEHG features a soft‐contact design, incorporating rabbit fur to supplement charges and enhance output density. This design also avoids direct material contact between generator units, improving operational durability. The experimental results show that the maximum output voltage and current of the TENG and EMG modules can respectively reach up to 270 V, 13 V, and 5.2 µA, 18 mA, and peak power to 2.04 mW, 10 mW. The CCT‐TEHG can function as a power source, sufficient to power 303 light‐emitting diodes (LEDs) or a 20 mW temperature and humidity sensor. Therefore, CCT‐TEHG has good application prospects in the field of bridge cable vibration energy harvest.
InGaN‐Based Whispering Gallery Mode Laser with Lateral Nanoporous Distributed Bragg Reflector Exhibits Superior Mode Selectivity
Authors: Zhao Lixia , Chen Jiawei , Lin Shan , Huang Yuqing , Ge Xiaotian , Wang Ting , Hu Tiangui , Ding Sunan , Wang Kaiyou 
Published: February 2024

AbstractWhispering gallery mode (WGM) laser with single‐mode is important for optoelectronic applications because of the higher stability during the light signal transmission. But till now, for InGaN‐based WGM laser, most reports of lasing behavior are multimode lasing. To achieve single‐mode WGM laser, an InGaN‐based micro‐ring laser is proposed and demonstrated with lateral nanoporous distributed Bragg reflector (DBR), where the high‐order lasing modes are strongly suppressed. The side mode suppression ratio (SMSR) is more than 9 times larger than that of the micro‐disk laser with the same radius. Combined with FDTD simulation, the results show that the enhancements are originated from the suppression of the high‐order resonant mode because of the inner boundary of micro‐ring. This work provides a new solution to achieve stable single‐mode WGM laser for future photonic integration.
Polydisperse particle inline image method and its application onto gas–liquid flow in a stirred tank
Authors: Wang Haoliang , Yang Li , Li Xiangyang , Cheng Jingcai , Yang Chao 
Published: February 2024

AbstractBubbles of different sizes exhibit distinct hydrodynamic behaviors and their dense coexistence complicates seriously the multiphase flow. The commonly‐used arithmetic average method (e.g., PIV) treats every bubble equally and consequently erases many physical details. In this study, a polydisperse particle inline image method is developed to simultaneously measure comprehensive feature set of every bubble in bubble swarms and carrier phase velocity. By harnessing the optimal frame rate capture alongside assigning IDs for tracking, complete identification of polydisperse swarm in single frame is integrated with the accurate acquisition of transient dynamics across multiple frames. In gas–liquid stirred tanks, the bubble deformation is notably intensified owing to the presence of collisions driven by velocity differences. A novel analysis of bubble hydrodynamics decomposed by bubble size reveals they are jointly commanded by the inertial effect and size effect. Actual flow regime of the system is essentially the superposition of multiple dissimilar flow patterns.
Mental health, coping, and protective factors in mothers of children with 22q11.2 deletion syndrome
Authors: McBride Haley , Jhawar Nandini , Boucicaut Laurie , Bearden Carrie E. , Kates Wendy R. , Woolf‐King Sarah E. , Antshel Kevin M. 
Published: February 2024

AbstractCompared to the large body of maternal mental health research for other pediatric disorders, we know far less about the experience of mothers of children with 22q11DS. This study investigates the coping methods, protective factors, and mental health of this population. These findings might lead to better support for 22q11DS maternal mental health. An international sample of 71 mothers (M = 40.5 years) of children with 22q11DS (M = 9.2 years) was recruited and completed an online survey assessing maternal mental health (symptoms of depression, anxiety, traumatic stress, general stress, and alcohol consumption), coping methods, and mental health protective factors (social support, dyadic adjustment, parenting competence). Maternal ratings of child mental health symptoms were also obtained. Mothers' self‐report revealed a high percentage who screened positive for elevated levels of general stress (69%), hazardous alcohol consumption (30.9%), traumatic stress (33.8%), anxiety (26.8%), and depression (26.8%). After controlling for demographic variables and child mental health symptoms, maternal self‐reported maladaptive coping methods were positively associated with maternal symptoms of depression, anxiety, stress, and traumatic stress. Reducing maladaptive coping methods may be a promising intervention for improving mental health in mothers of children with 22q11DS.
Dietary flexibility of the greater bamboo lemur (Prolemur simus), a specialized feeder, in eastern Madagascar
Authors: Mihaminekena T. Hasimija , Rakotonanahary Ando N. , Frasier Cynthia L. , Randriahaingo Hery N. T. , Sefczek Timothy M. , Tinsman Jen , Randrianarimanana H. Lucien , Ravaloharimanitra Maholy , Rakotoarinivo Toky Hery , Ratsimbazafy Jonah , King Tony , Louis Edward E. 
Published: February 2024

AbstractThe degree of dietary flexibility in primates is species specific; some incorporate a wider array of resources than others. Extreme interannual weather variability in Madagascar results in seasonal resource scarcity which has been linked to specialized behaviors in lemurs. Prolemur simus, for example, has been considered an obligate specialist on large culm bamboo with >60% of its diet composed of woody bamboos requiring morphological and physiological adaptations to process. Recent studies reported an ever‐expanding list of dietary items, suggesting that this species may not be an obligate specialist. However, long‐term quantitative feeding data are unavailable across this species’ range. To explore the dietary flexibility of P. simus, we collected data at two northern sites, Ambalafary and Sahavola, and one southern site, Vatovavy, from September 2010 to January 2016 and May 2017 to September 2018, respectively. In total, we recorded 4022 h of behavioral data using instantaneous sampling of adult males and females from one group in Ambalafary, and two groups each in Sahavola and Vatovavy. We recorded 45 plant species eaten by P. simus over 7 years. We also observed significant differences in seasonal dietary composition between study sites. In Ambalafary, bamboo was the most frequently observed resource consumed (92.2%); however, non‐bamboo resources comprised nearly one‐third of the diet of P. simus in Sahavola and over 60% in Vatovavy. Consumption of all bamboo resources increased during the dry season at Ambalafary and during the wet season at Vatovavy, but never exceeded non‐bamboo feeding at the latter. Culm pith feeding was only observed at Ambalafary, where it was more common during the dry season. We identify P. simus as a bamboo facultative specialist capable of adjusting its feeding behavior to its environment, indicating greater dietary flexibility than previously documented, which may enable the species to survive in increasingly degraded habitats.
O‐Trifluoromethylation of Carboxylic Acids via the Formation and Activation of Acyloxy(phenyl)trifluoromethyl‐λ3‐Iodanes
Authors: Zhu Hongye , Gao Chi , Yu Ting , Xu Cong , Wang Mang 
Published: February 2024

AbstractHere we report the challenging O‐trifluoromethylation of carboxylic acids via the formation and activation of acyloxy(phenyl)trifluoromethyl‐λ3‐iodanes. The method provides an easy access to various potentially valuable and hitherto elusive trifluoromethyl carboxylic esters. A remarkably wide range of substrates with commonly encountered functional groups are compatible with this reaction, including aromatic and aliphatic carboxylic acids, as well as Food and Drug Administration (FDA) approved drugs and pharmaceutically relevant molecules. The reaction mechanism and the origins of the enhanced reactivity by zinc chloride (ZnCl2) were discussed from experimental evidence and density functional theory (DFT) calculation.
Connections to the Electrodes Control the Transport Mechanism in Single‐Molecule Transistors
Authors: Chen Zhixin , Woltering Steffen L. , Limburg Bart , Tsang Ming‐Yee , Baugh Jonathan , Briggs G. Andrew D. , Mol Jan A. , Anderson Harry L. , Thomas James. O. 
Published: February 2024

AbstractWhen designing a molecular electronic device for a specific function, it is necessary to control whether the charge‐transport mechanism is phase‐coherent transmission or particle‐like hopping. Here we report a systematic study of charge transport through single zinc‐porphyrin molecules embedded in graphene nanogaps to form transistors, and show that the transport mechanism depends on the chemistry of the molecule–electrode interfaces. We show that van der Waals interactions between molecular anchoring groups and graphene yield transport characteristic of Coulomb blockade with incoherent sequential hopping, whereas covalent molecule–electrode amide bonds give intermediately or strongly coupled single‐molecule devices that display coherent transmission. These findings demonstrate the importance of interfacial engineering in molecular electronic circuits.
Enhancing Ni/Co Activity by Neighboring Pt Atoms in NiCoP/MXene Electrocatalyst for Alkaline Hydrogen Evolution
Authors: Niu Hua‐Jie , Huang Chuanxue , Sun Tong , Fang Zhen , Ke Xiaoxing , Zhang Ruimin , Ran Nian , Wu Jianbo , Liu Jianjun , Zhou Wei 
Published: February 2024

AbstractDensity functional theory (DFT) calculations demonstrate neighboring Pt atoms can enhance the metal activity of NiCoP for hydrogen evolution reaction (HER). However, it remains a great challenge to link Pt and NiCoP. Herein, we introduced curvature of bowl‐like structure to construct Pt/NiCoP interface by adding a minimal 1 ‰‐molar‐ratio Pt. The as‐prepared sample only requires an overpotential of 26.5 and 181.6 mV to accordingly achieve the current density of 10 and 500 mA cm−2 in 1 M KOH. The water dissociation energy barrier (Ea) has a ~43 % decrease compared with NiCoP counterpart. It also shows an ultrahigh stability with a small degradation rate of 10.6 μV h−1 at harsh conditions (500 mA cm−2 and 50 °C) after 3000 hrs. X‐ray photoelectron spectroscopy (XPS), soft X‐ray absorption spectroscopy (sXAS), and X‐ray absorption fine structure (XAFS) verify the interface electron transfer lowers the valence state of Co/Ni and activates them. DFT calculations also confirm the catalytic transition step of NiCoP can change from Heyrovsky (2.71 eV) to Tafel step (0.51 eV) in the neighborhood of Pt, in accord with the result of the improved Hads at the interface disclosed by in situ electrochemical impedance spectroscopy (EIS) and scanning electrochemical microscopy (SECM) tests.
Solvothermal single‐pot synthesis of Pd‐Fe3O4@GO catalyst: Enhanced catalytic performance in Sonogashira coupling reactions
Authors: Pawar Mahesh A. , Nakhate Akhil V. , Kadu Samidha S. , Tekade Pradip V. 
Published: February 2024

In this study, we present a new approach to synthesizing a magnetically separable Pd‐Fe3O4@GO catalyst using a simple single‐pot method. The catalyst was employed in Sonogashira coupling reactions, demonstrating excellent results. The catalyst was studied using a various characterization method, including X‐ray photoelectron spectroscopy (XPS), scanning electron microscope–energy‐dispersive X‐ray spectroscopy (SEM‐EDS) mapping, TEM, X‐ray diffraction (XRD), FTIR, and inductively coupled plasma mass spectrometry (ICP‐MS). Pd‐Fe3O4@GO exhibited superior catalytic activity compared with its conventional counterparts in phenylacetylene‐iodobenzene coupling reactions under copper co‐catalyzed‐free and ligand‐free conditions, with a higher turnover frequency (TOF) of 118.3 h−1. Optimized conditions yielded high yields for various substrates, including inactive aryl chloride and bromide substrates, emphasizing its versatility. Also, a reaction mechanism was proposed and a kinetic model was developed. The catalyst's green chemistry potential was highlighted because of its high efficiency, purity of products, recoverability, and ease of preparation. Moreover, Pd‐Fe3O4@GO demonstrated impressive stability through multiple recycling rounds without loss of functionality, making it a promising tool for sustainable chemical processes.