bluuebunny/crossref_metadata_2025_split huggingface dataset:
Co‐production of health and social science research with vulnerable children and young people: A rapid review
Authors: Erwin Jo , Burns Lorna , Devalia Urshla , Witton Robert , Shawe Jill , Wheat Hannah , Axford Nick , Doughty Janine , Kaddour Sarah , Nelder Abigail , Brocklehurst Paul , Boswell Skye , Paisi Martha 
Published: February 2024

AbstractBackgroundThe term ‘care‐experienced’ refers to anyone who is currently in care or has been in care at any stage in their life. A complex interplay of factors leads to care‐experienced children and young people (CECYP) experiencing poorer oral health and access to dental care than their peers. A rapid review of the co‐production of health and social care research with vulnerable children and young people (CYP) was carried out to inform the development of a co‐produced research project exploring the oral health behaviours and access to dental services of CECYP. Here, ‘co‐production’ refers to the involvement of CYP in the planning or conduct of research with explicit roles in which they generate ideas, evidence and research outputs.AimTo learn how to meaningfully involve vulnerable CYP in the co‐production of health and social science research.ObjectivesTo identify: Different approaches to facilitating the engagement of vulnerable CYP in co‐production of health and social science research; different activities carried out in such approaches, challenges to engaging vulnerable CYP in co‐production of health and social science research and ways to overcome them and areas of best practice in relation to research co‐production with vulnerable CYP.Search StrategyA rapid review of peer‐reviewed articles was conducted in six databases (MEDLINE, Embase, SocINDEX, CINAHL, PsycINFO and Web of Science) and grey literature to identify studies that engaged vulnerable CYP in co‐approaches to health and social research.Main ResultsOf 1394 documents identified in the search, 40 were included and analysed. A number of different approaches to co‐production were used in the studies. The CYP was involved in a range of activities, chiefly the development of data collection tools, data collection and dissemination. Individual challenges for CYP and researchers, practical and institutional factors and ethical considerations impacted the success of co‐production.Discussion and ConclusionCo‐production of health and social science with vulnerable CYP presents challenges to researchers and CYP calling for all to demonstrate reflexivity and awareness of biases, strengths and limitations. Used appropriately and well, co‐production offers benefits to researchers and CYP and can contribute to research that reflects the needs of vulnerable CYP. Adherence to the key principles of inclusion, safeguarding, respect and well‐being facilitates this approach.Patient and Public ContributionMembers of our patient and public involvement and stakeholder groups contributed to the interpretation of the review findings. This manuscript was written together with a young care leaver, Skye Boswell, who is one of the authors. She contributed to the preparation of the manuscript, reviewing the findings and their interpretation.
The effect of root canal preparation tapers on planktonic bacteria and biofilm reduction in the apical third: A correlative microtomography and microbiological laboratory study
Authors: Macedo Fernanda Piffer Garcia , Soares Adriana de Jesus , Marceliano‐Alves Marília Fagury Videira , Martinez Elizabeth , Lopes Ricardo , Bastos Luan Ferreira , Nascimento Wayne Martins , Limoeiro Ana Grasiela , dos Frozoni Marcos 
Published: February 2024

AbstractAimTo evaluate the influence of different preparation tapers on the reduction in planktonic bacteria and biofilms of Enterococcus faecalis and Candida albicans in the apical third (4 mm) of the mesial roots of mandibular molars, correlating decontamination with canal shape.MethodologyAfter microtomography analysis for morphological standardization of the canals, 48 mandibular molar roots, each containing two canals (96 canals), were contaminated with E. faecalis and C. albicans and divided into four groups (n = 11) for canal instrumentation using ProDesign Logic 2 files with different tapers G (.03): # 25.03; G (.04): # 25.04; G (.05): # 25.05; and G (.06): # 25.06 and irrigation with 2.5% sodium hypochlorite. Four roots were examined under a scanning electron microscope (SEM) to qualitatively assess biofilm formation. Eight roots were used as the negative control group (samples were not contaminated). Bacteriological samples were taken exclusively from the apical third of the roots before and after chemical–mechanical preparation and bacterial counts were determined (CFU/mL). The final micro‐CT scan was used to quantify the volume variation and unprepared canal area in the apical third. Statistical analysis was performed using the Kruskal–Wallis, Student–Newman–Keuls and Wilcoxon tests for analysis of microbiological data. anova and the Tukey or Games–Howell test were used for analysis of micro‐CT data and Spearman's test for correlations (α = 5%).ResultsAll groups showed a significant reduction in bacteria (p < .05), with no statistically significant difference between groups. There was no significant difference in per cent volume increase between groups. The unprepared area (Δ%) was affected by the file used (p = .026) and was significantly lower for G (.06) compared to G (.03). There was no statistically significant correlation among bacterial reduction, volume and unprepared area (p > .05).ConclusionThe different preparation tapers influenced root canal shaping in the apical third but did not improve decontamination in this region.
Physico‐chemical characteristics of flours obtained from raw, roasted and autoclaved Cucurbita, Passiflora and Annona seeds
Authors: Artica Mallqui Luis , Baquerizo Canchumanya Mery , Rosales Papa Hermes , Rodríguez Gilbert , Aguirre Elza , Hidalgo Alyssa 
Published: February 2024

SummaryFruit seeds often have interesting nutritional characteristics as well as antinutrients, which may be inactivated by thermal processes. The aim of this work was to study the characteristics of flours obtained from raw, roasted or autoclaved (121 °C, 10 min) seeds of Cucurbita maxima, Cucurbita ficifolia, Passiflora ligularis, Annona cherimola and Annona muricata by analysing their chemical composition, protein in vitro digestibility, content of antinutrients (tannins, phytates and oxalates) and functional properties. All the flours presented high protein (15.3–36.7 g/100 g) and fat (22.7–41.8 g/100 g) contents. Roasting and autoclaving increased in vitro protein digestibility (from 45.6% to 57.8% and 72.1%, respectively) and decreased antinutrient content (from 100.3 to 75.6 and 82.0 mg tannins/100 g; from 158.1 to 137.8 and 104.0 mg phytates/100 g; from 19.6 to 12.8 and 13.3 mg oxalates/100 g, respectively). Water and oil absorption capacities increased, while emulsion and foaming capacities as well as bulk density decreased during thermal processing. The flours from autoclaved seeds showed improved nutritional and functional characteristics and could be considered as functional food ingredients for direct human consumption and/or in food mixtures. Future studies should be performed to evaluate the presence of allergens and other possible risk factors.
Lycopene and β‐carotene thermal degradation kinetics and colour‐antioxidant changes in gac (Momordica cochinchinensis) fruit aril paste
Authors: Syawalluddin Nur Salina , Abdul Rahman Hafeedza , Lim Seng Joe , Wan Mustapha Wan Aida , Mohd Razali Noorul Syuhada , Kasim Khairul Farihan , Aziz Nurul Shahirah , Sofian‐Seng Noor‐Soffalina 
Published: February 2024

SummaryThis study investigated the impact of heating temperatures (70 °C to 90 °C for up to 14 h) on lycopene and β‐carotene degradation kinetics in gac aril paste. Carotenoids extracted via low‐volume hexane‐assisted ultrasonic extraction revealed a first‐order degradation pattern with high correlation coefficients (0.96–0.97). Lycopene degraded faster at 90 °C (k = 12.05 × 102 h−1) than at 70 °C (5.41 × 102 h−1), while β‐carotene displayed relatively slower degradation. Corresponding half‐life (t1/2) values for lycopene ranged from 5.75 to 12.81 h, while β‐carotene displayed values of 9.48–20.2 h. β‐carotene showed superior thermal stability compared to lycopene across all temperatures. Additionally, colour changes indicated decreased brightness with increasing temperature. The DPPH radical scavenging activity and FRAP values decreased during gac fruit heating. Overall, this study emphasises temperature‐induced declines in lycopene and β‐carotene levels in gac aril paste and offers insights into their degradation kinetics under thermal processing.
Cushing syndrome and tertiary adrenal insufficiency from prolonged concomitant use of budesonide and posaconazole
Authors: Grigg Andrew 
Published: February 2024

AbstractBudesonide is a ‘non‐absorbable’ corticosteroid often used for gut graft versus host disease. Systemic exposure is usually minimal because of metabolism by cytochrome (CYP) 3A4 in enterocytes and the liver. However, concomitant use of posaconazole and voriconazole, inhibitors of CYP3A4 commonly used as antifungal prophylaxis in allograft patients receiving immunosuppression, can lead to substantial systemic steroid exposure. This paper describes a case of severe iatrogenic Cushing syndrome and tertiary adrenal insufficiency because of this interaction, highlighting the necessity for improved awareness of this phenomenon.
How does economic growth impact environmental quality in Ethiopia? A non‐linear approach
Authors: Abate Chala Amante 
Published: February 2024

AbstractFueled by economic growth, among other factors, environmental degradation is one of the most serious challenges facing humanity in the twenty‐first century. Although extensive research has been conducted on the relationship between economic growth and environmental quality, the findings are inconclusive. This study investigated the relationship between economic growth and environmental quality in Ethiopia from 1981 to 2016 using non‐linear autoregressive distributive lag and two‐step least squares models. First, the study finds that the relationship between economic growth and environmental quality is asymmetric. Second, economic growth negatively affects environmental quality. Third, the positive environmental effect of a negative shock on economic growth is stronger than that of a positive shock. Fourth, energy consumption and population growth negatively affect environmental quality, whereas the effects of renewable energy consumption, natural resources, trade openness and human capital are positive. Fifth, an inverted N‐shaped relationship exists between economic growth and environmental quality, where GDP per capita greater than $686.770 contributes to environmental quality. Therefore, high and sustainable economic growth, renewable energy consumption, population control, resource conservation, trade openness and human capital accumulation are required to improve the environmental quality of Ethiopia. The limitation of this study is that it examines the direct impact of economic growth on environmental quality. It would be better to examine the potential indirect impact of economic growth via variables, such as institutional quality and human capital.
Micro‐scale mechanical properties of surface layer in ion‐exchanged glass
Authors: Fujita Saho , Ohji Tatsuki , Yahagi Tsukaho , Iijima Motoyuki , Tatami Junichi 
Published: February 2024

AbstractToday, ion‐exchanged or chemically strengthened glass is ubiquitously used all over the world, typically for scratch‐free display cover of personal mobile phones. It has been known that the strengthening is due to developments of high compressive stress in the surface layer by its internally constrained dilation . We investigated micro‐scale mechanical properties of the surface layer itself of a Na+‐to‐K+ ion‐exchanged soda lime silicate glass, revealing that the strength of the layer increased nearly 40% by the ion‐exchange with little compression effect from the interior. The fracture toughness, however, was comparable before and after the ion‐exchange, indicating that the ion‐exchange reduces the crack size of the fracture origin. Theoretical estimates of fracture surface energies verified the measured fracture toughness. It was presumed that the observed crack‐size reduction is due to crack healing effects enhanced by the ion‐exchange.
Surveillance esophagogastroduodenoscopy using linked color imaging and narrow‐band imaging: A multicenter randomized controlled trial
Authors: Kubo Marina , Ono Shoko , Dohi Osamu , Fukui Hayato , Hikichi Takuto , Kato Tsunetaka , Tsuda Momoko , Matsumoto Mio , Kato Sosuke , Mukai Rieko , Yagi Nobuaki , Takagi Ryo , Sakamoto Naoya , Kato Mototsugu ,   LAN Trial Group
Published: February 2024

AbstractBackground and AimThere has been no report on a direct comparison between linked color imaging (LCI) and second‐generation narrow‐band imaging (2G‐NBI) for surveillance of epithelial neoplasms in the upper gastrointestinal tract (UGIT). The aim of this study was to verify the superiority of LCI to 2G‐NBI for surveillance esophagogastroduodenoscopy and to clarify how each endoscopic system should be used.MethodsThis study was conducted as an open‐label, two‐arm‐parallel (1:1), multicenter, randomized controlled trial at six institutions. Patients aged 20–85 years with a treatment history of epithelial neoplasms in the UGIT were recruited. Patients were assigned to a 2G‐NBI group and an LCI group, and esophagogastroduodenoscopy was performed with primary image‐enhanced endoscopy followed by white light imaging (WLI). The primary endpoint was the detection rate of one or more epithelial neoplasms in the primary image‐enhanced endoscopy. A WLI‐detected epithelial neoplasm was defined as a lesion that was detected in only WLI.ResultsA total of 372 patients in the 2G‐NBI group and 378 patients in the LCI group were analyzed. Epithelial neoplasms in the UGIT were detected by 2G‐NBI in 18 patients (4.6%) and were detected by LCI in 20 patients (5.3%) (P = 0.87). WLI‐detected epithelial neoplasms were in 11 patients in the 2G‐NBI group (3.0%) and in 1 patient in the LCI group (0.27%) (P = 0.003).ConclusionsLinked color imaging did not show superiority to 2G‐NBI for the detection of epithelial neoplasms. Also, the percentage of WLI‐detected epithelial neoplasms in primary NBI was significantly higher than that in primary LCI.
Development and prenatal exposure to androgens alter potassium currents in gonadotropin‐releasing hormone neurons from female mice
Authors: Jaime Jennifer , DeFazio R. Anthony , Moenter Suzanne M. 
Published: February 2024

AbstractPulsatile gonadotropin‐releasing hormone (GnRH) release is critical for reproduction. Disruptions to GnRH secretion patterns may contribute to polycystic ovary syndrome (PCOS). Prenatally androgenized (PNA) female mice recapitulate many neuroendocrine abnormalities observed in PCOS patients. PNA and development induce changes in spontaneous GnRH neuron firing rate, response to synaptic input, and the afterhyperpolarization potential of the action potential. We hypothesized potassium currents are altered by PNA treatment and/or development. Whole‐cell patch‐clamp recordings were made of transient and residual potassium currents of GnRH neurons in brain slices from 3‐week‐old and adult control and PNA females. At 3 weeks of age, PNA treatment increased transient current density versus controls. Development and PNA altered voltage‐dependent activation and inactivation of the transient current. In controls, transient current activation and inactivation were depolarized at 3 weeks of age versus in adulthood. In GnRH neurons from 3‐week‐old mice, transient current activation and inactivation were more depolarized in control than PNA mice. Development and PNA treatment interacted to shift the time‐dependence of inactivation and recovery from inactivation. Notably, in cells from adult PNA females, recovery was prolonged compared to all other groups. Activation of the residual current occurred at more depolarized membrane potentials in 3‐week‐old than adult controls. PNA depolarized activation of the residual current in adults. These findings demonstrate the properties of GnRH neuron potassium currents change during typical development, potentially contributing to puberty, and further suggest PNA treatment may both alter some typical developmental changes and induce additional modifications, which together may underlie aspects of the PNA phenotype. There was not any clinical trial involved in this work.
“If I got it, she got it”: Black mothers' food provision and symbiotic mothering
Authors: Hill Marbella Eboni , Fern Simon E. , Kimbro Rachel , Hughes Cayce C. 
Published: February 2024

AbstractObjectiveThis study advances contemporary theories of motherhood, mothering, and foodwork within the context of poverty by focusing on the ways that low‐income Black mothers engage interdependent culturally distinct mothering strategies in light of a porous social safety net.BackgroundContemporary standards for good parenting are increasingly resource‐based.As such, the intricate and tactical ways that low‐income Black mothers manage to make food ends meet with little means and few resources are often obscured in favor of hegemonic forms of mothering.MethodThis study draws on 44 in‐depth interviews with low‐income Black mothers and grandmothers to examine their survival strategies, focusing on food provision.ResultsFindings reveal that these mothers prioritize basic needs provision, such as food and feeding, and achieve this often difficult goal by engaging a cultural toolkit that we term symbiotic mothering. Symbiotic mothering is constructed and reinforced through the collective processes of maternal exchange, mutual aid and resource pooling, and the intergenerational and horizontal transmission of cultural knowledges, values, and practices.ConclusionsWhile there is a wealth of scholarship interrogating the ways Black women deviate from dominant mothering expectations, symbiotic mothering highlights the unique cultural skillsets these mothers actively engage to meet the everyday demands of mothering, particularly related to food provision.
Denture relining using digital replication method: A dental technique
Authors: Gad Mohammed M. , Alalawi Haidar , Al‐Qarni Faisal D. , Al‐Harbi Fahad A. 
Published: February 2024

AbstractThe aim of this report was to digitize traditional denture relining using a digital duplication method, in addition to assessing the wear resistance of three‐dimensional (3D) printed denture teeth. A complete denture was relined using light body impression. The denture with impression was scanned yielding a standard tessellation language file that was designed to print the denture base and teeth. The printed teeth were fitted into the sockets of the printed denture base and then bonded using auto‐polymerized acrylic resins, followed by finishing and polishing. Dentures were inserted and fit and occlusion were adjusted as needed, and the patient was scheduled for follow‐up appointments at one week, three months, and six months. At each follow‐up visit, dentures were scanned using a 3Shape E3 desktop scanner and scans were superimposed. The occlusal wear was assessed in reference to the first scan after the denture insertion visit. The accuracy of the intaglio surface of dentures was within clinically acceptable limits. The clinical evaluation of inserted dentures in terms of retention, occlusion, esthetic, and patient satisfaction was encouraging. Using digital duplication, conventional dentures could be relined. The advantages of digital records include eliminating polymerization dimensional changes, and reducing cost and clinical time by minimizing the number of visits, which is particularly helpful with geriatric patients.
Working from home, commuting time, and intracity house‐price gradients
Authors: Kim Jinwon , Long Dede 
Published: February 2024

AbstractThe popularity of working from home (WFH) in the US has surged over the past two decades, with the COVID‐19 pandemic further accelerating this trend. We hypothesize that WFH not only reduces the frequency of physical commutes but also lowers the time cost of commutes due to decreased urban congestion levels; both factors would flatten house‐price gradients. Analyzing big data from Google Maps on travel time in California, we first confirm that COVID‐19, as a WFH‐boosting shock, induced larger decreases in morning travel time in cities with a higher WFH potential. We then empirically validate the effect of WFH on house‐price gradients, channeled through its impact on commuting time; this effect explains 20% of the total WFH‐induced flattening of house‐price gradients during the pandemic in California.
Roles for leakiness and O2 evolution in explaining lower‐than‐theoretical quantum yields of photosynthesis in the PEP‐CK subtype of C4 plants
Authors: Ouyang Wenjing , Wientjes Emilie , van der Putten Peter E. L. , Caracciolo Ludovico , Zhao Ruixuan , Agho Collins , Chiurazzi Maurizio Junior , Bongers Marius , Struik Paul C. , van Amerongen Herbert , Yin Xinyou 
Published: February 2024

Summary
Theoretically, the PEP‐CK C4 subtype has a higher quantum yield of CO2 assimilation () than NADP‐ME or NAD‐ME subtypes because ATP required for operating the CO2‐concentrating mechanism is believed to mostly come from the mitochondrial electron transport chain (mETC). However, reported is not higher in PEP‐CK than in the other subtypes. We hypothesise, more photorespiration, associated with higher leakiness and O2 evolution in bundle‐sheath (BS) cells, cancels out energetic advantages in PEP‐CK species.
Nine species (two to four species per subtype) were evaluated by gas exchange, chlorophyll fluorescence, and two‐photon microscopy to estimate the BS conductance (gbs) and leakiness using a biochemical model.
Average gbs estimates were 2.9, 4.8, and 5.0 mmol m−2 s−1 bar−1, and leakiness values were 0.129, 0.179, and 0.180, in NADP‐ME, NAD‐ME, and PEP‐CK species, respectively. The BS CO2 level was somewhat higher, O2 level was marginally lower, and thus, photorespiratory loss was slightly lower, in NADP‐ME than in NAD‐ME and PEP‐CK species. Differences in these parameters existed among species within a subtype, and gbs was co‐determined by biochemical decarboxylating sites and anatomical characteristics.
Our hypothesis and results partially explain variations in observed , but suggest that PEP‐CK species probably use less ATP from mETC than classically defined PEP‐CK mechanisms.
Unpacking the point of no return under drought in poplar: insight from stem diameter variation
Authors: Andriantelomanana Tsiky , Améglio Thierry , Delzon Sylvain , Cochard Hervé , Herbette Stephane 
Published: February 2024

Summary
A specific, robust threshold for drought‐induced tree mortality is needed to improve the prediction of forest dieback. Here, we tested the relevance of continuous measurements of stem diameter variations for identifying such a threshold, their relationship with hydraulic and cellular damage mechanisms, and the influence of growth conditions on these relationships.
Poplar saplings were grown under well‐watered, water‐limited, or light‐limited conditions and then submitted to a drought followed by rewatering. Stem diameter was continuously measured to investigate two parameters: the percentage loss of diameter (PLD) and the percentage of diameter recovery (DR) following rewatering. Water potentials, stomatal conductance, embolism, and electrolyte leakage were also measured, and light microscopy allowed investigating cell collapse induced by drought.
The water release observed through loss of diameter occurred throughout the drought, regardless of growth conditions. Poplars did not recover from drought when PLD reached a threshold and this differed according to growth conditions but remained linked to cell resistance to damage and collapse.
Our findings shed new light on the mechanisms of drought‐induced tree mortality and indicate that PLD could be a relevant indicator of drought‐induced tree mortality, regardless of the growth conditions.