bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural history of craniovertebral abnormalities in a single-center study in 54 patients with Hurler syndrome
Authors: Huang Shiwei , Nascene David R. , Shanley Ryan , Pena-Pino Isabela , Lund Troy C. , Gupta Ashish O. , Orchard Paul J. , Sandoval-Garcia Carolina 
Published: March 2024

OBJECTIVE
Craniovertebral junction (CVJ) abnormalities are common and well documented in mucopolysaccharidosis type I–Hurler syndrome (MPS IH), often causing severe spinal canal narrowing. However, the requirement for surgical decompression and/or fusion is uncommon. Although hematopoietic cell transplant (HCT) has been shown to prolong the lives of patients with MPS IH, its effect in halting or reversing musculoskeletal abnormalities is less clear. Unfortunately, there are currently no universal guidelines for imaging or indication for surgical interventions in these patients. The goal of this study was to track the progression of the CVJ anatomy in patients with MPS IH following HCT, and to examine radiographic features in patients who needed surgical intervention.

METHODS
Patients with MPS IH treated at the University of Minnesota with allogeneic HCT between 2008 and 2020 were retrospectively reviewed. Patients who underwent CVJ surgery were identified with chart review. All MPS IH cervical scans were examined, and the odontoid retroflexion angle, clivoaxial angle (CXA), canal width, and Grabb-Oakes distance (pB-C2) were measured yearly for up to 7 years after HCT. Longitudinal models based on the measurements were made. An intraclass correlation coefficient was used to measure interrater reliability. Nine children without MPS IH were examined for control CVJ measurements.

RESULTS
A total of 253 cervical spine MRI scans were reviewed in 54 patients with MPS IH. Only 4 (7.4%) patients in the study cohort required surgery. Three of them had posterior fossa and C1 decompression, and 1 had a C1–2 fusion. There was no statistically significant difference in the spinal parameters that were examined between surgery and nonsurgery groups. Among the measurements, canal width and CXA varied drastically in patients with different neck positions. Odontoid retroflexion angle and CXA tended to decrease with age. Canal width and pB-C2 tended to increase with age.

CONCLUSIONS
Based on the data, the authors observed an increase in canal width and pB-C2, whereas the CXA and odontoid retroflexion angle became more acute as the patients aged after HCT. The longitudinal models derived from these data mirrored the development in children without MPS IH. Spinal measurements obtained on MR images alone are not sufficient in identifying patients who require surgical intervention. Symptom monitoring and clinical examination, as well as pathological spinal cord changes on MRI, are more crucial in assessing the need for surgery than is obtaining serial imaging.
Pediatric brain tumors in sub-Saharan Africa: a systematic review and meta-analysis
Authors: Nyalundja Arsene Daniel , Kanmounye Ulrick Sidney , Karekezi Claire , Laeke Tsegazeab , Thango Nqobile , Balogun James A. 
Published: March 2024

OBJECTIVE
Brain tumors are a global problem, leading to higher cancer-related morbidity and mortality rates in children. Despite the progressive though slow advances in neuro-oncology care, research, and diagnostics in sub-Saharan Africa (SSA), the epidemiological landscape of pediatric brain tumors (PBTs) remains underestimated. This study aimed to systematically analyze the distribution of PBT types in SSA.

METHODS
Ovid Medline, Global Index Medicus, African Journals Online, Google Scholar, and faculty of medicine libraries were searched for literature on PBTs in SSA published before October 29, 2022. A proportional meta-analysis was performed.

RESULTS
Forty-nine studies, involving 2360 children, met the inclusion criteria for review; only 20 (40.82%) were included in the quantitative analysis. South Africa and Nigeria were the countries with the most abundant data. Glioma not otherwise specified (NOS) was the common PBT in the 4 SSA regions combined. However, medulloblastoma was more commonly reported in Southern SSA (p = 0.01) than in other regions. The prevalence and the overall pooled proportion of the 3 common PBTs was estimated at 46.27% and 0.41 (95% CI 0.32–0.50, 95% prediction interval [PI] 0.11–0.79), 25.34% and 0.18 (95% CI 0.14–0.21, 95% PI 0.06–0.40), and 12.67% and 0.12 (95% CI 0.09–0.15, 95% PI 0.04–0.29) for glioma NOS, medulloblastoma, and craniopharyngioma, respectively. Sample size moderated the estimated proportion of glioma NOS (p = 0.02). The highest proportion of craniopharyngiomas was in Western SSA, and medulloblastoma and glioma NOS in Central SSA.

CONCLUSIONS
These findings provide insight into the trends of PBT types and the proportion of the top 3 most common tumors across SSA. Although statistical conclusions are difficult due to the inconsistency in the data, the study identifies critical areas for policy development and collaborations that can facilitate improved outcomes in PBTs in SSA. More accurate epidemiological studies of these tumors are needed to better understand the burden of the disease and the geographic variation in their distribution, and to raise awareness in their subsequent management.
The identification of risk factors and outcomes of cerebrospinal fluid shunt infections caused by carbapenem-resistant gram-negative bacteria in children: a retrospective cohort
Authors: Guner Ozenen Gizem , Sahbudak Bal Zumrut , Bolat Elif , Umit Zuhal , Bilen Nimet M. , Yildirim Arslan Sema , Turhan Tuncer , Cilli Feriha , Kurugol Zafer 
Published: March 2024

OBJECTIVE
Cerebrospinal fluid (CSF) shunt infections caused by gram-negative bacteria are difficult to treat given the limited treatment options and the emergence of carbapenem-resistant (CR) strains. This study aimed to evaluate the demographic and clinical characteristics of children with CSF shunt and external ventricular drain (EVD) infections caused by gram-negative bacteria, to identify the risk factors for acquiring CR CSF shunt infections, and to report on the clinical outcomes of these infections.

METHODS
A retrospective cohort study was designed to evaluate pediatric patients with CSF shunt and EVD infections caused by gram-negative bacteria between January 2013 and February 2023.

RESULTS
A total of 64 episodes in 50 patients were evaluated. There were 45 (70.3%) CSF shunt infections and 19 (29.7%) EVD infections. The median (range) ages were 1.4 years (9 months–17.5 years) for CSF shunt infection patients and 4.2 years (1 month–17 years) for EVD infection patients. The most common isolated gram-negative bacteria species in CSF shunt infections were Pseudomonas spp. (12, 26.7%), followed by Escherichia coli (11, 24.4%), Klebsiella pneumoniae (9, 20%), and Enterobacter cloacae (5, 11.1%). In EVD infections, the most common isolated gram-negative bacteria species were Acinetobacter spp. (6, 31.6%), followed by Pseudomonas spp. (4, 21.1%) and E. coli (3, 15.8%). The carbapenem resistance rate was 26.3% (n = 5) in EVD infections and 26.2% (n = 11) in CSF shunt infections. When risk factors for carbapenem resistance were evaluated for CSF shunt infections, prior carbapenem treatment and a prolonged hospital stay > 7 days were risk factors for the CR group (p = 0.032 and p = 0.042, respectively). In definitive treatment, colistin was statistically more commonly used in the CR group (p = 0.049). When outcomes were evaluated, the 30-day mortality rate (18.2% vs 0%) was higher in the CR group, without a significant difference (p = 0.064).

CONCLUSIONS
A prolonged hospital stay > 7 days and prior carbapenem exposure within 30 days were associated with CR shunt infections caused by gram-negative bacteria.
Neurocognitive outcomes and associated clinical factors 5 years after surgery in children with craniosynostosis
Authors: Kim Joo Whan , Kim Kyung Hyun , Phi Ji Hoon , Lee Ji Yeoun , Koh Eun Jung , Kim Byung Jun , Chung Jee Hyeok , Shin Min-Sup , Kim Seung-Ki 
Published: March 2024

OBJECTIVE
Craniosynostosis involves early closure of one or more sutures, which is known to limit normal cranium growth and interfere with normal brain development. Various surgical methods are used, ranging from minimally invasive strip craniectomy to more extensive whole-vault cranioplasty. This study aimed to evaluate neurocognitive outcomes 5 years after surgical treatment in children with craniosynostosis and to evaluate relevant clinical factors.

METHODS
After exclusion of genetically confirmed syndromic craniosynostosis patients, a retrospective review was conducted on 112 nonsyndromic craniosynostosis patients who underwent surgical treatment and follow-up neurocognitive assessment. Ninety-seven patients underwent strip craniectomy with postoperative orthotic helmet therapy, and 15 received other surgical treatment: 4 with distraction osteotomy and 11 with craniofacial reconstruction. Neurocognitive assessment using the Korean Wechsler Preschool and Primary Scale of Intelligence, Fourth Edition (K-WPPSI-IV), was performed 5 years postoperatively. Clinical factors were assessed regarding neurocognitive outcomes.

RESULTS
The mean age at surgery was significantly younger in the strip craniectomy group (strip craniectomy 4.6 months vs other surgical treatment 18.6 months, p < 0.01). Patients with 2 or more sutures involved were more likely to receive more extensive surgical treatment (16.5% in the strip craniectomy group vs 53.8% in the other group, p < 0.01). Four (3.5%) patients who showed evidence of increased intracranial pressure (ICP) also underwent more extensive surgical treatment. Multivariable linear regression revealed a significant correlation of age at neurocognitive testing (−3.18, 95% CI −5.95 to −0.40, p = 0.02), increased ICP (−34.73, 95% CI −51.04 to −18.41, p < 0.01), and the level of maternal education (6.11, 95% CI 1.01–11.20, p = 0.02) with the Full-Scale Intelligence Quotient (FSIQ). Age at surgery, involvement of 2 or more sutures, and type of operation demonstrated no correlation with FSIQ. Among the 97 patients who underwent strip craniectomy, the FSIQ ranged from mean ± SD 100.2 ± 10.2 (bicoronal) to 110.1 ± 12.7 (lambdoid), and there was no significant difference between the suture groups (p = 0.41). The 5 index scores were all within average ranges based on their age norms.

CONCLUSIONS
Age at neurocognitive assessment, increased ICP, and maternal education level showed significant correlations with the neurocognitive function of craniosynostosis patients. Although children with craniosynostosis exhibited favorable 5-year postoperative neurocognitive outcomes across various synostosis sutures, longer follow-up is needed to reveal the incidence of neurocognitive dysfunction in these patients.
Quality of Life in Pelvic Organ Prolapse Patients with Operative Therapy at RSUP Dr. Mohammad Hoesin
Authors: Almenata Mutia Adilah , Putra Hadrians Kesuma , Purnamasari Septi , Krisna Ratih , Martadiansyah Abarham 
Published: March 2024

Introduction. Pelvic organ prolapse is a condition where the pelvic organs descend from their original position and protrude into the vagina. This condition causes several complaints in the patients that can interfere with their daily activities and have an impact on their quality of life. One of the treatments that can be given to patients with POP is operative therapy, which one of the goals is to improve patient's quality of life. This study aims to determine the quality of life of pelvic organ prolapse patients with operative therapy at Dr. Mohammad Hoesin Hospital Palembang. Methods. This study used an observational analytical method with a cross-sectional study design. This study consisted of 17 respondents. This study used primary data from interviews using the P-QOL questionnaire guidelines and secondary data from medical records. Results. This study showed an improvement in the quality of life of pelvic organ prolapse patients in all P-QOL quality of life domains (p<0.05) after receiving operative therapy compared to before receiving operative therapy. Analysis of the effect of confounding factors on the total quality of life score showed that age (p=0.138), BMI (p=0.999), parity (p=0.468), degree of POP (p=0.439), and type of surgery (p=0.814) did not have a significant influence on the quality of life of postoperative POP patients. Conclusion. There was a significant improvement in the quality of life in pelvic organ prolapse patients after receiving operative therapy, and there is no significant relationship between age, BMI, parity, degree of POP, also type of surgery on the quality of life in postoperative POP patients.
PELATIHAN BUDIDAYA JAMUR TIRAM BAGI MASYARAKAT DESA TANJUNG TERDANA KECAMATAN PONDOK KUBANG BENGKULU TENGAH UNTUK MENDUKUNG KETAHANAN PANGAN
Authors: Jumiarni Dewi , Rendi Zulni Eka Putri  
Published: March 2024

Masyarakat Desa Tanjung Terdana Bengkulu Tengah belum memiliki sumber keterampilan teknologi tepat guna yang memadai yang dapat digunakan sebagai sumber penghasilan selain bertani. Kegiatan pelatihan ini dilakukan bertujuan untuk meningkatkan pengetahuan dan keterampilan masyarakat dalam budidaya jamur tiram. Metode kegiatan meliputi tiga tahapan kegiatan yaitu Persiapan, Pelatihan dan Praktek, Monitoring dan Evaluasi. Hasil dari kegiatan pelatihan ini telah meningkatkan pengetahuan dan keterampilan peserta dalam budidaya jamur tiram dengan N-gain sebesar 0,85 atau dengan kategori tinggi. Respon peserta terhadap materi pelatihan menunjukkan bahwa peserta memahami materi pelatihan yang diberikan. Sedangkan respon peserta terhadap metode pelatihan menunjukkan bahwa peserta sangat memahami metode pelatihan yang diberikan.
Kata kunci: budidaya jamur tiram, ketahanan pangan, pelatihan
Application of Problem-based Learning Models Assisted By Liveworksheets Towards Students' Mathematical Creative Thinking Ability
Authors: Sari Intan Puspita , Jusra Hella 
Published: March 2024

The ability to think creatively mathematically of students is relatively low.The purpose of this research is to determine whether employing the Liveworksheets-assisted Problem Based Learning technique influences students' mathematics ability to think creatively. This study used quantitative research methods and a non-equivalent post-test only control group design. The sampling technique employs non-probability sampling. The sample for this study consisted of two classes with 71 students.The normality and homogeneity tests are used in quantitative research as part of the preconditioning test. In this study, the hypothesis was tested using an independent sample test. This study's findings illustrate students' mathematics creative thinking ability in experimental classrooms influenced by the usage of the Problem Based Learning model using liveworksheets. This demonstrates that the experimental class's students have a greater potential for mathematical creative thinking ability than the control class.The application of problem based learning models assisted by liveworksheets influences the student’s mathematical creative thinking ability.
Analysis of Teacher Interpretation of the Depth and Breadth of Middle School Level Global Warming Material using "Content Representation" (CoRe)
Authors: Yanti Meili , Rahmadhani Aulia 
Published: March 2024

Global warming is a material presented at the VII grade junior high school level. This material is very complex so it causes different interpretations by everyone when teaching it. Therefore, this research aims to analyze teachers' interpretations of the depth and breadth of global warming material contained in KD 3.9 of the 2013 Curriculum. This research was conducted descriptively using the Content Representation instrument to obtain information about teachers' interpretations. Participants in this study were junior high school 11 science teachers who are members of the MGMP community in Majene Regency, West Sulawesi. The results of this study indicate that teachers interpret KD 3.9 quite completely. This was obtained from the CoRe instrument where teachers fill in essential concepts to teach global warming material. The results show that teachers with more than 10 years of teaching experience have a greater variety of teaching methods and assessments in teaching global warming material. In addition, global warming materials were also obtained based on their depth and breadth.
JURIDICAL STUDY OF CHILDREN WHO WORK AS INFLUENCERS IN RECEIVING ENDORSEMENTS IN SOCIAL MEDIA
Authors: Nasanta Ester , Wahyudi Eko 
Published: March 2024

Child influencers are a profession that can channel the talents and interests of the child in positive terms, one of which is by receiving endorsements. Endorsement is a support in the form of cooperation between companies and celebrities/influencers by promoting a product produced by the company and bound by a valid agreement. As in Indonesia, many public figures raise their children to become influencers from an early age. In this case, what is the view of the child influencer profession according to positive law in Indonesia, bearing in mind that there are frequent reports of public figures suspected of exploiting children and their legal protection for child influencers in receiving endorsements on social media in the event of data leakage and default, both from the company or from the endorser himself.
This study uses normative legal research methods, namely discussing the doctrine of legal facts, principles, norms, and principles in the science of law, which focuses on laws and regulations related to working children, electronic transaction systems, and child protection using a statutory approach. invitation or statue approach..
The results of this study explain the legal views regarding the child influencer profession according to positive law in Indonesia, which begins with the position of child influencers as endorsers, forms of legal violations that can occur when receiving endorsements on social media and legal protection efforts for child influencers as a whole. preventive and repressive.
IMPLEMENTATION OF PERMA NUMBER 1 OF 2016 CONCERNING MEDIATION IN SETTLEMENT OF INHERITANCE CASES IN SURABAYA RELIGIOUS COURT
Authors: Setiawan Baharudin , Waluyo  
Published: March 2024

In this study, the authors used an empirical juridical method, namely research that aims to find out and analyze the implementation of Supreme Court Regulation Number 1 of 2016 concerning Mediation in the settlement of inheritance cases at the Surabaya Religious Court (Case Study: Application for Inheritance at the Surabaya Religious Court), and data sources were obtained from interviews with various parties related to the implementation of mediation at the Surabaya Religious Court, data obtained from the Surabaya Religious Court, legislation, and various literature.
The results of this study can be concluded that many inheritance cases in the Surabaya Religious Court have not succeeded in obtaining a peace certificate in the mediation process. Mediation has not been carried out optimally because there are still obstacles both from the Surabaya Religious Court and from external parties. These obstacles include mediators, parties, and attorneys. Based on the results of research conducted by the authors of the various inhibiting factors that arise in the mediation implementation process, there are still efforts that can be made. Efforts made include the parties and attorneys must have good faith in carrying out the mediation.
Efektivitas Waktu Perubahan Perilaku Lanjut Usia Pengguna Gigi Tiruan Lengkap dengan Menggunakan Video Pembersihan Gigi Tiruan Lengkap
Authors: Falatehan Niko , Johannis Stefano D. 
Published: March 2024

Abstract: Aging process brings about several problems, particularly in the realm of oral health inter alia tooth loss in elderly. Dental prosthetic treatments, such as complete denture treatment can be employed to restore aesthetic, masticatory, and phonetic functions. The timing of follow-up appointments significantly influences the success of complete denture treatments. This study aimed to determine the effectiveness of using educational videos of cleaning complete dentures on time of behavior change among the elderly residents at Panti Jompo Pusaka 41 Yayasan Al-Madiniyah. This was an experimental study with a cross-sectional design using a questionnaire consisting of 15 questions. The results obtained 22 elderlies as subjects. Data collection was performed four times: before the video intervention; control I (one day after the video intervention); control II (one week after control I); and control III (two weeks after control II). Changes in elderly behavior were tested using the Friedman test. The results showed that the most significant change of behavior was during control I, which was one day after receiving instructions in the form of a video. The Friedman test resulted in a p-value of 0.001. In conclusion, the best follow-up time that resulted in the most significant improvement in behavior is control I, which is one day after the administration of instructional videos.
Keywords: elderly; complete denture; control time; educational videos; behaviour

Abstrak: Bertambahnya usia akan menimbulkan beberapa permasalahan, khususnya di bidang kesehatan gigi dan mulut; salah satunya ialah kehilangan gigi pada kelompok lanjut usia (lansia). Pada kehilangan gigi dapat dilakukan perawatan gigi tiruan lengkap (GTL) untuk mengembalikan fungsi estetik, mastikasi, dan fonetik. Waktu kontrol memiliki pengaruh besar dalam keberhasilan perawatan GTL. Penelitian ini bertujuan untuk mengetahui efektivitas penggunaan video edukasi pembersihan GTL terhadap waktu perubahan perilaku lansia pengguna GTL di Panti Jompo Pusaka 41 Yayasan Al-Madiniyah. Jenis penelitian ialah eksperimental dengan desain potong lintang dan menggunakan kuesioner berisi 15 pertanyaan. Pengambilan data dilakukan sebanyak empat kali, yaitu sebelum diberikan video; kontrol I, sehari setelah pemberian video; kontrol II, satu minggu setelah kontrol I; dan kontrol III, dua minggu setelah kontrol II. Perubahan perilaku lansia diuji menggunakan uji Friedman. Hasil penelitian ini mendapatkan 22 lansia sebagai subjek penelitian. Perilaku lansia mengalami perubahan paling bermakna pada saat kontrol I dengan hasil uji p=0,001. Simpulan penelitian ini ialah waktu kontrol terbaik yang memberikan peningkatan perilaku paling bermakna ialah kontrol I, yaitu sehari setelah pemberian instruksi berupa video.
Kata kunci: lanjut usia; gigi tiruan lengkap; waktu kontrol; video edukasi
FIXING THE CHAIN: THE DATA ENRICHMENT CYCLE IN PROGNOSTIC HEALTH MONITORING
Authors: Akkermans Henk , Kempen Paul van 
Published: March 2024

Only a very modest percentage of maintenance of capital goods is done condition-based, as opposed to plan-based or corrective. Doing much more would be very beneficial from a safety and operations perspective. Moreover, the basic methods have been known for some time. This paper addresses the question that, if condition-based maintenance (CBM) or Prognostic Health Management (PHM), as the terms commonly used to denote the same maintenance policy, is so logical and beneficial, why is it currently not more often applied in practice?This paper suggests that the answer lies in a complex interplay of technical and organizational issues. This interplay is best conceptualized as a data enrichment chain, which starts and ends at the physical asset to be maintained and ends at the actual prognostic maintenance being executed and evaluated. This chain is described in more detail, and illustrated with examples from an open innovation project in the process industry in the Netherlands, the CAMPIONE fieldlab. From this description, it becomes evident that this chain is currently broken in many places. If CBM/PHM is to become more established as a business practice, these breaks will need to be fixed. The paper discusses several of the options of how to fix this data enrichment chain in practice.