bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remaking Makers
Authors: Finch Michael P M 
Published: March 2024

Abstract
This chapter focuses on the development of Peter Paret’s Makers of Modern Strategy: From Machiavelli to the Nuclear Age in the first half of the 1980s. It explains how Paret’s career led to the editorship of Makers despite a long-held reticence towards engagement with contemporary concerns, contextualizes the genesis of the book as part of a broader re-emphasis of historical study in strategic thinking that began in the 1970s, and illuminates the manner in which the editorial team of Paret, Felix Gilbert, and Gordon Craig coalesced. It charts the four-year production of the book, reflecting on the similarities with many of the challenges encountered forty years earlier, as the editors strove towards a volume that was scaffolded on the original edition but which sought to place much heavier emphasis on the importance of the USA.
The Work of Literature in the Age of the Refugee
Authors: Goyal Yogita 
Published: March 2024

Abstract
This essay considers the specific challenges that attend the study of the figure of the refugee, probing the valence of historical and geopolitical comparison alongside the limits and possibilities of literary methods. Considering recent books on the literature of migration, the essay examines the aftermath of twentieth-century wars in Asian American, Caribbean, Latinx, and US literary criticism.
Simultaneous variable selection and estimation in semiparametric regression of mixed panel count data
Authors: Ge Lei , Hu Tao , Li Yang 
Published: March 2024

AbstractMixed panel count data represent a common complex data structure in longitudinal survey studies. A major challenge in analyzing such data is variable selection and estimation while efficiently incorporating both the panel count and panel binary data components. Analyses in the medical literature have often ignored the panel binary component and treated it as missing with the unknown panel counts, while obviously such a simplification does not effectively utilize the original data information. In this research, we put forward a penalized likelihood variable selection and estimation procedure under the proportional mean model. A computationally efficient EM algorithm is developed that ensures sparse estimation for variable selection, and the resulting estimator is shown to have the desirable oracle property. Simulation studies assessed and confirmed the good finite-sample properties of the proposed method, and the method is applied to analyze a motivating dataset from the Health and Retirement Study.
Comparing two spatial variables with the probability of agreement
Authors: Acosta Jonathan , Vallejos Ronny , Ellison Aaron M , Osorio Felipe , de Castro Mário 
Published: March 2024

ABSTRACT
Computing the agreement between 2 continuous sequences is of great interest in statistics when comparing 2 instruments or one instrument with a gold standard. The probability of agreement quantifies the similarity between 2 variables of interest, and it is useful for determining what constitutes a practically important difference. In this article, we introduce a generalization of the PA for the treatment of spatial variables. Our proposal makes the PA dependent on the spatial lag. We establish the conditions for which the PA decays as a function of the distance lag for isotropic stationary and nonstationary spatial processes. Estimation is addressed through a first-order approximation that guarantees the asymptotic normality of the sample version of the PA. The sensitivity of the PA with respect to the covariance parameters is studied for finite sample size. The new method is described and illustrated with real data involving autumnal changes in the green chromatic coordinate (Gcc), an index of “greenness” that captures the phenological stage of tree leaves, is associated with carbon flux from ecosystems, and is estimated from repeated images of forest canopies.
Victims, Perpetrators and Bystanders: Atrocity and Its Aftermath in the Films of Jasmila Žbanić
Authors: Aydın-Aitchison Andy 
Published: March 2024

Abstract
The paper excavates ‘implicit criminologies’ concerning victims, perpetrators and bystanders from four films by Bosnian director Jasmila Žbanić: Grbavica (2006); On the path (2010); For those who can tell no tales (2013) and Quo Vadis, Aida? (2020). I argue that in criminological terms, Žbanić’s work is strongest, and has greatest transformative potential, as an example of cinematic victimology. This is produced through characters who simultaneously encapsulate particular (ethnicized) and universal elements in micro-level stories of the individual in a larger social, political and historical context. Focussing on this form of universalism, I question an ethical standard of inclusivity in atrocity cinema which calls for a single film or director to directly represent victims of all ethnic groups.
The effective connectivity analysis of fMRI based on asymmetric detection of transfer brain entropy
Authors: Shi Yuhu , Li Yidan 
Published: March 2024

Abstract
It is important to explore causal relationships in functional magnetic resonance imaging study. However, the traditional effective connectivity analysis method is easy to produce false causality, and the detection accuracy needs to be improved. In this paper, we introduce a novel functional magnetic resonance imaging effective connectivity method based on the asymmetry detection of transfer entropy, which quantifies the disparity in predictive information between forward and backward time, subsequently normalizing this disparity to establish a more precise criterion for detecting causal relationships while concurrently reducing computational complexity. Then, we evaluate the effectiveness of this method on the simulated data with different level of nonlinearity, and the results demonstrated that the proposed method outperforms others methods on the detection of both linear and nonlinear causal relationships, including Granger Causality, Partial Granger Causality, Kernel Granger Causality, Copula Granger Causality, and traditional transfer entropy. Furthermore, we applied it to study the effective connectivity of brain functional activities in seafarers. The results showed that there are significantly different causal relationships between different brain regions in seafarers compared with non-seafarers, such as Temporal lobe related to sound and auditory information processing, Hippocampus related to spatial navigation, Precuneus related to emotion processing as well as Supp_Motor_Area associated with motor control and coordination, which reflects the occupational specificity of brain function of seafarers.
SGLT2 inhibitors: from glucose-lowering to cardiovascular benefits
Authors: Preda Alberto , Montecucco Fabrizio , Carbone Federico , Camici Giovanni G , Lüscher Thomas F , Kraler Simon , Liberale Luca 
Published: March 2024

Abstract
An increasing number of individuals are at high risk of type 2 diabetes (T2D) and its cardiovascular complications, including heart failure (HF), chronic kidney disease (CKD), and eventually premature death. The sodium-glucose co-transporter-2 (SGLT2) protein sits in the proximal tubule of human nephrons to regulate glucose reabsorption and its inhibition by gliflozins represents the cornerstone of contemporary T2D and HF management. Herein, we aim to provide an updated overview of the pleiotropy of gliflozins, provide mechanistic insights and delineate related cardiovascular (CV) benefits. By discussing contemporary evidence obtained in preclinical models and landmark randomized controlled trials, we move from bench to bedside across the broad spectrum of cardio- and cerebrovascular diseases. With landmark randomized controlled trials confirming a reduction in major adverse CV events (MACE; composite endpoint of CV death, non-fatal myocardial infarction, and non-fatal stroke), SGLT2 inhibitors strongly mitigate the risk for heart failure hospitalization in diabetics and non-diabetics alike while conferring renoprotection in specific patient populations. Along four major pathophysiological axes (i.e. at systemic, vascular, cardiac, and renal levels), we provide insights into the key mechanisms that may underlie their beneficial effects, including gliflozins’ role in the modulation of inflammation, oxidative stress, cellular energy metabolism, and housekeeping mechanisms. We also discuss how this drug class controls hyperglycaemia, ketogenesis, natriuresis, and hyperuricaemia, collectively contributing to their pleiotropic effects. Finally, evolving data in the setting of cerebrovascular diseases and arrhythmias are presented and potential implications for future research and clinical practice are comprehensively reviewed.
Intestinal Adipocytes Transdifferentiate into Myofibroblast-like Cells and Contribute to Fibrosis in Crohn’s Disease
Authors: Geng Zhijun , Li Jing , Zuo Lugen , Zhang Xiaofeng , Wang Lian , Xia Yongsheng , Yang Jingjing , Yin Lixia , Song Xue , Wang Yueyue , Chai Damin , Deng Min , Ge Yuanyuan , Wu Rong , Hu Jianguo 
Published: March 2024

Abstract

Background and Aims
Intestinal fibrotic stenosis is a major reason for surgery in Crohn’s disease [CD], but the mechanism is unknown. Thus, we asked whether intestinal adipocytes contribute to intestinal fibrosis. Adipocytes were found to transdifferentiate into myofibroblasts and confirmed to be involved in mesenteric fibrosis in our recent study. Here, we investigated the role and possible mechanisms of intestinal adipocytes in intestinal fibrosis in CD.

Methods
The intestinal tissue of patients with CD with or without fibrotic stenosis [CDS or CDN] and normal intestinal tissue from individuals without CD were obtained to assess alterations in submucosal adipocytes in CDS and whether these cells transdifferentiated into myofibroblasts and participated in the fibrotic process. Human primary adipocytes and adipose organoids were used to evaluate whether adipocytes could be induced to transdifferentiate into myofibroblasts and to investigate the fibrotic behaviour of adipocytes. LPS/TLR4/TGF-β signalling was also studied to explore the underlying mechanism.

Results
Submucosal adipocytes were reduced in number or even absent in CDS tissue, and the extent of the reduction correlated negatively with the degree of submucosal fibrosis. Interestingly, submucosal adipocytes in CDS tissue transdifferentiated into myofibroblast-like cells and expressed collagenous components, possibly due to stimulation by submucosally translocated bacteria. Lipopolysaccharide [LPS]-stimulated human primary adipocytes and adipose organoids also exhibited transdifferentiation and profibrotic behaviour. Mechanistically, TLR4-mediated TGF-β signalling was associated with the transdifferentiation and profibrotic behaviour of intestinal adipocytes in CDS tissue.

Conclusions
Intestinal adipocytes transdifferentiate into myofibroblasts and participate in the intestinal fibrosis process in CD, possibly through LPS/TLR4/TGF-β signalling.
Accelerated MEN2A in homozygous RET carriers in the context of consanguinity
Authors: Machens Andreas , Dralle Henning 
Published: March 2024

Abstract

Background
Homozygous mutations, 2 identical gene versions (alleles), 1 from each biological parent, are exceptional. Clinical descriptions of affected families, comprising few carriers only, are scattered throughout the literature, hindering evidence generation.

Methods
Included in this literature analysis were 5 RET families with ≥1 homozygous carrier and ≥3 heterozygous carriers per family.

Results
In consanguineous families with first-degree cousins, homozygotes presented with node-positive medullary thyroid cancer and pheochromocytoma in their mid-teens, whereas heterozygotes presented in their end-30s and early 40s. Homozygotes developed node-positive medullary thyroid cancer 27.4 years and pheochromocytoma 23 years earlier than heterozygotes. These age differences were smaller in the 15 families carrying founder mutation p.Leu666delinsAsnSer, whereas homozygotes developed node-positive medullary thyroid cancer in their mid-40s, 6 years earlier than heterozygotes in their early 50s.

Conclusion
These results, limited in scope and size and modulated by extent of consanguinity, are consistent with moderate dose–response effects accelerating MEN2A development.
Forensic DNA phenotyping: a review on SNP panels, genotyping techniques, and prediction models
Authors: Terrado-Ortuño Nuria , May Patrick 
Published: March 2024

Abstract
In the past few years, forensic DNA phenotyping has attracted a strong interest in the forensic research. Among the increasing publications, many have focused on testing the available panels to infer biogeographical ancestry on less represented populations and understanding the genetic mechanisms underlying externally visible characteristics. However, there are currently no publications that gather all the existing panels limited to forensic DNA phenotyping and discuss the main technical limitations of the technique. In this review, we performed a bibliographic search in Scopus database of phenotyping-related literature, which resulted in a total of 48, 43, and 15 panels for biogeographical ancestry, externally visible characteristics, and both traits inference, respectively. Here we provide a list of commercial and non-commercial panels and the limitations regarding the lack of harmonization in terms of terminology (i.e., categorization and measurement of traits) and reporting, the lack of genetic knowledge and environment influence to select markers and develop panels, and the debate surrounding the selection of genotyping technologies and prediction models and algorithms. In conclusion, this review aims to be an updated guide and to present an overview of the current related literature.
Decadal (2010–2019) variability in the marine ecosystems of the North Atlantic
Authors: González-Pola César , Mills Katherine E , Beszczynska-Möller Agnieszka , Bresnan Eileen , Birchenough Silvana N R 
Published: March 2024

Abstract
The “Symposium on Decadal Variability of the North Atlantic and its Marine Ecosystems: 2010–2019” took place in Bergen, Norway, from 20 to 22 May 2022. This event, hosted by the Institute of Marine Research, was jointly sponsored by ICES and NAFO and constitutes the fourth in a series of these symposia that started in 1991. The first symposium’s aim was to review the hydrobiological variability in the decade of the 1980s, addressing the physical environment, plankton, invertebrates, and fish. Subsequent symposia maintained the classical structure, whilst a new theme session covering social sciences was added to the programme in the 2022 edition. Studies of climate impacts on marine ecosystems and living marine resources, including trends and regime shifts, emerged from increasingly longer ecosystem time series across the North Atlantic and subarctic regions. This symposium collection presents key findings discussed during the symposium. Whilst some progress has been made in advancing our ability to understand new trends and patterns of climate change and variability across physical, plankton, and fish communities, more work is needed to integrate these physical-ecological processes and scales with social science.
In-situ heating-and-electron tomography for materials research: from 3D (in-situ 2D) to 4D (in-situ 3D)
Authors: Hata Satoshi , Ihara Shiro , Saito Hikaru , Murayama Mitsuhiro 
Published: March 2024

Abstract
In-situ observation has expanded the application of transmission electron microscopy (TEM) and has made a significant contribution to materials research and development for energy, biomedical, quantum, etc. Recent technological developments related to in-situ TEM have empowered the incorporation of three-dimensional observation, which was previously considered incompatible. In this review article, we take up heating as the most commonly used external stimulus for in-situ TEM observation and overview recent in-situ TEM studies. Then, we focus on the electron tomography (ET) and in-situ heating combined observation by introducing the authors’ recent research as an example. Assuming that in-situ heating observation is expanded from two dimensions to three dimensions using a conventional TEM apparatus and a commercially available in-situ heating specimen holder, the following in-situ heating-and-ET observation procedure is proposed: (i) use a rapid heating-and-cooling function of a micro-electro-mechanical system holder; (ii) heat and cool the specimen intermittently and (iii) acquire a tilt-series dataset when the specimen heating is stopped. This procedure is not too technically challenging and can have a wide range of applications. Essential technical points for a successful 4D (space and time) observation will be discussed through reviewing the authors’ example application.
When all else fails: the colo-duodenal anastomosis
Authors: Dewhurst Suzannah L , Sarofim Mina , Wijayawardana Ruwanthi , Morris David L 
Published: March 2024

Abstract
Total enterectomy is an exceedingly rare procedure performed out of necessity due to massive intestinal infarction, trauma, or peritoneal malignancy. This case describes a 47-year-old patient who has successfully undergone the procedure to manage mesenteric ischaemia. Bowel continuity was achieved with a duodenocolonic anastomosis, and the patient has been transitioned to life-long total parental nutrition. This case highlights that carefully selected patients can achieve long-term survival with good quality of life rather than palliation.
Actinomyces as a rare cause of appendicitis: a case report
Authors: Gao Yijun , Jhamb Shaurya , Hayler Raymond , Trickett Chloe , Kwok Allan 
Published: March 2024

Abstract
Actinomycosis remains a rare and often underdiagnosed cause of appendicitis with only 10% of cases diagnosed prior to surgery. It is an important cause to consider particularly in the setting of an indolent infection with nonspecific symptoms. We present a 22 years old male who presented with 3 weeks history of lower abdominal pain who underwent laboratory investigations and imaging studies suggestive of acute appendicitis. He underwent an emergency laparoscopic caecectomy with histopathology of the specimen suggestive of actinomycosis. He recovered well postoperatively and was discharged home with a prolonged course of oral penicillins. Preoperative diagnosis of actinomycosis is uncommon and accounts for ~10% of cases. Definitive diagnosis is usually through histopathology or tissue/fluid culture. Treatment usually involves a combination of surgical resection and antibiotic therapy with a success rate of &gt;90%.
Genetic Basis and Evolutionary Forces of Sexually Dimorphic Color Variation in a Toad-Headed Agamid Lizard
Authors: Lu Bin , Qiu Xia , Yang Weizhao , Yao Zhongyi , Ma Xiaofeng , Deng Shunyan , Zhang Qi , Fu Jinzhong , Qi Yin 
Published: March 2024

Abstract
In the animal kingdom, sexually dimorphic color variation is a widespread phenomenon that significantly influences survival and reproductive success. However, the genetic underpinnings of this variation remain inadequately understood. Our investigation into sexually dimorphic color variation in the desert-dwelling Guinan population of the toad-headed agamid lizard (Phrynocephalus putjatai) utilized a multidisciplinary approach, encompassing phenotypic, ultrastructural, biochemical, genomic analyses, and behavioral experiments. Our findings unveil the association between distinct skin colorations and varying levels of carotenoid and pteridine pigments. The red coloration in males is determined by a genomic region on chromosome 14, housing four pigmentation genes: BCO2 and three 6-pyruvoyltetrahydropterin synthases. A Guinan population-specific nonsynonymous single nucleotide polymorphism in BCO2 is predicted to alter the electrostatic potential within the binding domain of the BCO2-β-carotene complex, influencing their interaction. Additionally, the gene MAP7 on chromosome 2 emerges as a potential contributor to the blue coloration in subadults and adult females. Sex-specific expression patterns point to steroid hormone-associated genes (SULT2B1 and SRD5A2) as potential upstream regulators influencing sexually dimorphic coloration. Visual modeling and field experiments support the potential selective advantages of vibrant coloration in desert environments. This implies that natural selection, potentially coupled with assortative mating, might have played a role in fixing color alleles, contributing to prevalence in the local desert habitat. This study provides novel insights into the genetic basis of carotenoid and pteridine-based color variation, shedding light on the evolution of sexually dimorphic coloration in animals. Moreover, it advances our understanding of the driving forces behind such intricate coloration patterns.
Challenges, limitations, and pitfalls of PET and advanced MRI in patients with brain tumors: A report of the PET/RANO group
Authors: Galldiks Norbert , Kaufmann Timothy J , Vollmuth Philipp , Lohmann Philipp , Smits Marion , Veronesi Michael C , Langen Karl-Josef , Rudà Roberta , Albert Nathalie L , Hattingen Elke , Law Ian , Hutterer Markus , Soffietti Riccardo , Vogelbaum Michael A , Wen Patrick Y , Weller Michael , Tonn Joerg-Christian 
Published: March 2024

Abstract
Brain tumor diagnostics have significantly evolved with the use of positron emission tomography (PET) and advanced magnetic resonance imaging (MRI) techniques. In addition to anatomical MRI, these modalities may provide valuable information for several clinical applications such as differential diagnosis, delineation of tumor extent, prognostication, differentiation between tumor relapse and treatment-related changes, and the evaluation of response to anticancer therapy. In particular, joint recommendations of the Response Assessment in Neuro-Oncology (RANO) Group, the European Association of Neuro-oncology, and major European and American Nuclear Medicine societies highlighted that the additional clinical value of radiolabeled amino acids compared to anatomical MRI alone is outstanding and that its widespread clinical use should be supported. For advanced MRI and its steadily increasing use in clinical practice, the Standardization Subcommittee of the Jumpstarting Brain Tumor Drug Development Coalition provided more recently an updated acquisition protocol for the widely used dynamic susceptibility contrast perfusion MRI. Besides amino acid PET and perfusion MRI, other PET tracers and advanced MRI techniques (e.g. MR spectroscopy) are of considerable clinical interest and are increasingly integrated into everyday clinical practice. Nevertheless, these modalities have shortcomings which should be considered in clinical routine. This comprehensive review provides an overview of potential challenges, limitations, and pitfalls associated with PET imaging and advanced MRI techniques in patients with gliomas or brain metastases. Despite these issues, PET imaging and advanced MRI techniques continue to play an indispensable role in brain tumor management. Acknowledging and mitigating these challenges through interdisciplinary collaboration, standardized protocols, and continuous innovation will further enhance the utility of these modalities in guiding optimal patient care.