bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Arctigenin as an Antitumor Agent Having the Ability to Eliminate the Tolerance of Cancer Cells to Nutrient Starvation
Authors: Awale Suresh , Lu Jie , Kalauni Surya K. , Kurashima Yukiko , Tezuka Yasuhiro , Kadota Shigetoshi , Esumi Hiroyasu 
Published: February 2006

Abstract
Tumor cells generally proliferate rapidly and the demand for essential nutrients as well as oxygen always exceeds the supply due to the unregulated growth and the insufficient and inappropriate vascular supply. However, cancer cells show an inherent ability to tolerate extreme conditions, such as that characterized by low nutrient and oxygen supply, by modulating their energy metabolism. Thus, targeting nutrient-deprived cancer cells may be a novel strategy in anticancer drug development. Based on that, we established a novel screening method to discover anticancer agents that preferentially inhibit cancer cell viability under the nutrient-deprived condition. After screening 500 medicinal plant extracts used in Japanese Kampo medicine, we found that a CH2Cl2-soluble extract of Arctium lappa exhibited 100% preferential cytotoxicity under the nutrient-deprived condition at a concentration of 50 μg/mL with virtually no cytotoxicity under nutrient-rich condition. Further bioassay-guided fractionation and isolation led to the isolation of arctigenin as the primary compound responsible for such preferential cytotoxicity; the compound exhibited 100% preferential cytotoxicity against nutrient-deprived cells at a concentration of 0.01 μg/mL. Furthermore, arctigenin was also found to strongly suppress the PANC-1 tumor growth in nude mice, as well as the growth of several of the tested pancreatic cancer cell lines, suggesting the feasibility of this novel antiausterity approach in cancer therapy. Further investigation of the mechanism of action of arctigenin revealed that the compound blocked the activation of Akt induced by glucose starvation, which is a key process in the tolerance exhibited by cancer cells to glucose starvation. (Cancer Res 2006; 66(3): 1751-7)
A Novel Small-Molecule Inhibitor of Protein Kinase Cι Blocks Transformed Growth of Non–Small-Cell Lung Cancer Cells
Authors: Stallings-Mann Melody , Jamieson Lee , Regala Roderick P. , Weems Capella , Murray Nicole R. , Fields Alan P. 
Published: February 2006

Abstract
We recently showed that atypical protein kinase Cι (PKCι) is required for transformed growth of human non–small-cell lung cancer (NSCLC) cells by activating Rac1. Genetic disruption of PKCι signaling blocks Rac1 activity and transformed growth, indicating that PKCι is a viable target for development of novel therapeutics for NSCLC. Here, we designed and implemented a novel fluorescence resonance energy transfer–based assay to identify inhibitors of oncogenic PKCι signaling. This assay was used to identify compounds that disrupt the interaction between PKCι and its downstream effector Par6, which links PKCι to Rac1. We identified aurothioglucose (ATG), a gold compound used clinically to treat rheumatoid arthritis, and the related compound, aurothiomalate (ATM), as potent inhibitors of PKCι-Par6 interactions in vitro (IC50 ∼1 μmol/L). ATG blocks PKCι-dependent signaling to Rac1 and inhibits transformed growth of NSCLC cells. ATG-mediated inhibition of transformation is relieved by expression of constitutively active Rac1, consistent with a mechanism at the level of the interaction between PKCι and Par6. ATG inhibits A549 cell tumor growth in nude mice, showing efficacy against NSCLC in a relevant preclinical model. Our data show the utility of targeting protein-protein interactions involving PKCι for antitumor drug development and provide proof of concept that chemical disruption of PKCι signaling can be an effective treatment for NSCLC. ATG and ATM will be useful reagents for studying PKCι function in transformation and represent promising new agents for the clinical treatment of NSCLC. (Cancer Res 2006; 66(3): 1767-74)
The c-myc Gene Is a Direct Target of Mammalian SWI/SNF–Related Complexes during Differentiation-Associated Cell Cycle Arrest
Authors: Nagl Norman G. , Zweitzig Daniel R. , Thimmapaya Bayar , Beck George R. , Moran Elizabeth 
Published: February 2006

Abstract
The activity of mammalian SWI/SNF–related chromatin remodeling complexes is crucial for differentiation, development, and tumor suppression. Cell cycle–regulating activities dependent on the complexes include induction of the p21WAF1/CIP1 kinase inhibitor and repression of E2F-responsive promoters. These responses are linked through effects on pRb phosphorylation, but the direct role of the SWI/SNF–related complexes in their regulation is not fully understood. Results presented here reveal that the complexes are required for regulation of a distinct pathway of proliferation control involving repression of c-myc expression in differentiating cells. This involves direct promoter targeting of the c-myc gene by the complexes. Induction of p21WAF1/CIP1 is specifically dependent on prior repression of c-myc, but repression of E2F-responsive genes is dissociable from the regulation of c-myc and p21WAF1/CIP1. (Cancer Res 2006; 66(3): 1289-93)
Germ Line Polymorphism in Metastatic Progression
Authors: Hunter Kent W. , Crawford Nigel P. 
Published: February 2006

Abstract
Somatic genetic analysis of tumors and metastases has yielded a plethora of information regarding genes associated with cancer progression. However, somatic alterations in tumor cells are only one source of variability. Genetic polymorphism may also play a significant role in person-to-person variability in metastasis frequency, raising the intriguing possibility that some individuals could be predisposed to secondary tumor development. The identification and characterization of these polymorphisms may have significant implications for the development of tailored treatment or prevention of recurrent disease. (Cancer Res 2006; 66(3): 1251-4)
'The Proof is on My Palm': Debating Ethnicity, Islam and Ritual in a New African Diaspora
Authors: Johnson Michelle 
Published: February 2006

AbstractFor Mandinga in Guinea-Bissau and Portugal, life-course rituals are currently provoking transnational debates on ethnic and religious identity. In Guinea-Bissau, these two identities are thought to be one and the same—to be Mandinga is to 'naturally' be Muslim. For Mandinga immigrants in Portugal, however, the experience of transnationalism and the allure of 'global Islam' have thrust this long-held notion into debate. In this article, I explore the contours and consequences of this debate by focusing on the 'writing-on-the-hand' ritual, which initiates Mandinga children into Qur'anic study. Whereas some Mandinga immigrants in Portugal view the writing-on-the-hand ritual as essential for conferring both Muslim identity and 'Mandinga-ness', others feel that this Mandinga 'custom' should be abandoned for a more orthodox version of Islam. Case studies reveal an internal debate about Mandinga ethnicity, Islam and ritual, one that transcends the common 'traditionalist'/'modernist' distinction. I suggest that the internal debate, although intensified by migration, is not itself a consequence of 'modernity' but has long been central to how Mandinga imagine themselves as both members of a distinct ethnic group and as practitioners of the world religion of Islam.
'Unhappily Torn by Dissensions and Litigations': Durban's 'Memon' Mosque, 1880–1930
Authors: Vahed Goolam 
Published: February 2006

AbstractThis study focuses on Durban's Grey Street mosque, built by Indian Memon migrants in 1880. This review of the first half-century of the mosque's existence underlines the important social role of mosques, and also questions the notion of homogeneous Muslim community. While the mosque was the most visible symbol of Muslim identity in Natal, it was also a site of contestation, reflecting the class, language, caste and ethnic divisions among Muslims in a diasporic situation. Mosques were built along class and ethnic lines and dominated by traders. As Muslim society matured, there were challenges to the leadership of non-clerical traders who did not tolerate challenges to their authority. Opposition sometimes centred on Imams who commanded the allegiance of the congregation. Mosques did not have an independent life but reflected the prevailing power structures in Muslim society. While outsiders believed that ethnic diversity was subsumed by a unitary Muslim mass, Muslims comprised a community of communities, and the building and management of mosques underlined this fact.
A High-Resolution Modeling Study of the 24 May 2002 Dryline Case during IHOP. Part II: Horizontal Convective Rolls and Convective Initiation
Authors: Xue Ming , Martin William J. 
Published: February 2006

Abstract
In Part I of this paper, the timing and location of convective initiation along a dryline on 24 May 2002 were accurately predicted, using a large 1-km-resolution nested grid. A detailed analysis of the convective initiation processes, which involve the interaction of the dryline with horizontal convective rolls, is presented here.
Horizontal convective rolls (HCRs) with aspect ratios (the ratio of roll spacing to depth) between 3 and 7 develop in the model on both sides of the dryline, with those on the west side being more intense and their updrafts reaching several meters per second. The main HCRs that interact with the primary dryline convergence boundary (PDCB) are those from the west side, and they are aligned at an acute angle with the dryline. They intercept the PDCB and create strong moisture convergence bands at the surface and force the PDCB into a wavy pattern. The downdrafts of HCRs and the associated surface divergence play an important role in creating localized maxima of surface convergence that trigger convection. The downward transport of westerly, southwesterly, or northwesterly momentum by the HCR downdrafts creates asymmetric surface divergence patterns that modulate the exact location of maximum convergence. Most of the HCRs have a partially cellular structure at their mature stage. The surface divergence flows help concentrate the background vertical vorticity and the vorticity created by tilting of environmental horizontal vorticity into vortex centers or misocyclones, and such concentration is often further helped by cross-boundary shear instability. The misocyclones, however, do not in general collocate with the maximum updrafts and, therefore, the points of convective initiation, but can help enhance surface convergence to their south and north.
Sequences of convective cells develop at the locations of persistent maximum surface convergence, then move away from the source with the midlevel winds. When the initial clouds propagate along the convergence bands that trigger them, they grow faster and become more intense. While the mesoscale convergence of dryline circulation preconditions the boundary layer by deepening the mixed layer and lifting moist air parcels to their LCL, it is the localized forcing by the HCR circulation that determines the exact locations of convective initiation. A conceptual model summarizing the findings is proposed.
Halloysite clay minerals — a review
Authors: Joussein E. , Petit S. , Churchman J. , Theng B. , Righi D. , Delvaux B. 
Published: February 2006

AbstractHalloysite clay minerals are ubiquitous in soils and weathered rocks where they occur in a variety of particle shapes and hydration states. Diversity also characterizes their chemical composition, cation exchange capacity and potassium selectivity. This review summarizes the extensive but scattered literature on halloysite, from its natural occurrence, through its crystal structure, chemical and morphological diversity, to its reactivity toward organic compounds, ions and salts, involving the various methods of differentiating halloysite from kaolinite. No unique test seems to be ideal to distinguish these 1:1 clay minerals, especially in soils. The occurrence of 2:1 phyllosilicate contaminants appears, so far, to provide the best explanation for the high charge and potassium selectivity of halloysite. Yet, hydration properties of the mineral probably play a major role in ion sorption. Clear trends seem to relate particle morphology and structural Fe. However, future work is required to understand the possible mechanisms linking chemical, morphological, hydration and charge properties of halloysite.
Iron mineralogy of mine-drainage precipitates as environmental indicators: review of current concepts and a case study from the Sokolov Basin, Czech Republic
Authors: Murad E. , Rojík P. 
Published: February 2006

AbstractMine-drainage waters and associated precipitates from several active and abandoned lignite mines and mine dumps in the Sokolov Basin, northwestern Czech Republic, were sampled and analysed. The data showed considerable variations of effluent composition and pH that can generally be related to differences in the local microenvironments. Temporal changes such as seasonal fluctuations of precipitation, leading to variations of water infiltration through and runoff over mines and mine dumps, were also observed to noticeably affect effluent composition. These variations have led to a wide range of precipitates, the principal constituents of which are generally one or several of the ferric minerals jarosite, schwertmannite, goethite, ferrihydrite and lepidocrocite.The present paper consists of two parts: a short review of the genesis and properties of the named minerals, and a study of mine-drainage precipitates formed under different local conditions in various lignite mines and mine dumps of the Sokolov mining district. We show that variations in mine-drainage precipitate mineralogy, such as the presence or absence of specific ‘key’ minerals, can serve as indicators for factors such as the pH and sulphate concentration, and thus — with certain limitations — for the genetic environment during precipitate formation. Such variations in composition are reflected, among other properties, in the precipitate colour, which can therefore be used for a rapid identification and classification — both in the field and by remote sensing — of regions that are potentially prone to acid mine drainage.
How kaolinite plays an essential role in remediating oil-polluted seawater
Authors: Chaerun S. K. , Tazaki K. 
Published: February 2006

AbstractAn investigation was carried out on the bioavailability of kaolinite and the role it plays in remediating oil-polluted seawater, since kaolinite is known to enable hydrocarbon-degrading bacteria to grow well. Experimental results revealed that significant amounts of Al and Si dissolved from kaolinite were not observed ((P > 0.05) in comparison with a control sample which contained no kaolinite) in the aqueous phase during the ~24 day experimental period. Transmission electron microscope observations and energy-dispersive spectroscope data revealed that some altered kaolinite particles appeared, connected to intact kaolinite and bacterial cells. Bacterial cells were associated and encrusted with intact and/or altered kaolinite clay particles, where mixed (C, O, Na and Si)-precipitates of kaolinite clays were formed on the surface of hydrocarbon-degrading bacterial cells. However, the uptake of Si (from kaolinite) by bacterial cells appeared to be more prevalent than Al, and there were no significant changes in basal spacings of kaolinite due to these altered kaolinite particles. Separate studies showed that hydrocarbon-degrading bacteria have a high resistance to Si. Thus, the present data suggest that Si from kaolinite may facilitate hydrocarbon-degrading bacterial growth as shown in our previous study (Chaerun et al., 2005), and the C-O-Na-Si complexes on the surfaces of bacterial cell walls may be the stimulator for hydrocarbon-degrading bacterial growth in seawater contaminated with oil spill.
Immobilization of α-amylase onto K-10 montmorillonite: characterization and comparison of activity in a batch and a fixed-bed reactor
Authors: Sanjay G. , Sugunan S. 
Published: February 2006

Abstractα-amylase was immobilized on acid-activated montmorillonite K-10 via adsorption and covalent linkage. The immobilized enzymes were characterized by X-ray diffraction (XRD), surface area measurements,27Al nuclear magnetic resonance (NMR) and scanning electron microscopy (SEM). Surface area measurements indicate pore blockage due to linking of the enzyme in the vicinity of the pore mouth. The XRD demonstrates intercalation of enzyme upon immobilization. The NMR studies indicate that, during adsorption, tetrahedral Al sites are involved, while covalent binding occurs exclusively on the octahedral Al sites. The SEM images depict the changed morphology of the clay surface due to immobilization. The efficiency of immobilized enzymes for starch hydrolysis was tested in a batch and a fixed-bed reactor and the performances were compared. The immobilized α-amylase showed a broad pH profile and improved stability characteristics in both reactor types when compared to the free enzyme. The effectiveness factor increased in the fixed-bed reactor, implying that diffusional restrictions to mass transfer operate in the heterogeneous reaction and the use of a fixed-bed reactor leads to a reduction in these diffusional resistances. In the continuous run, 100% initial activity was maintained for 72 h, and after 96 h, >80% activity was retained.
Structural modifications of smectites mechanically deformed under controlled conditions
Authors: Christidis G. E. , Dellisanti F. , Valdre G. , Makri P. 
Published: February 2006

AbstractSWy-1 and SAz-1 smectites and an Italian bentonite from Sardinia were mechanically deformed via high-energy ball milling for 20 h, in a controlled thermodynamic environment at constant temperature (25°C) under vacuum. The deformed smectites have a lower cation exchange capacity (CEC) and form thicker particles than the original ones, due to agglomeration of smectite crystallites. The 001 diffraction maximum shifted to lower d spacings, the intensity of the 060 reflection decreased and the background at 20-30°2θ increased, suggesting partial amorphization of the smectite. Moreover, the layer charge of the smectites decreased. The intensity of the complex stretching band at 3625 cm-1, and the AlAlOH, and AlFe3+OH bending bands at 916 cm-1 and 886 cm-1, respectively, decreased, while the band at AlMgOH bending at 849 cm-1, disappeared. Deformation mainly disrupted the octahedral sheet and preferentially destroyed those sites occupied by Mg cations, thus explaining the observed decrease in layer charge. Octahedral sites occupied by Fe were least affected. The disruption of the octahedral sheet is substantiated further by the almost total disappearance of the dehydroxylation peak, which is more pronounced in the Mg-rich SAz-1 smectite.
Mineralogical and trace element composition of clay-sized fractions from Albian siliciclastic rocks (Oliete Basin, NE Spain)
Authors: González López J. M. , Bauluz B. , Yuste A. , Mayayo M. J. , Fernández-Nieto C. 
Published: February 2006

AbstractMineralogical and geochemical techniques have been used to determine the role of minerals in controlling the trace element composition of a set of clay-sized fractions from Albian siliciclastic rocks in NE Spain. These clay-sized fractions are composed of kaolinite and illite, minor quantities of quartz, and accessory heavy minerals. Kaolinite has a smaller crystal size than illite, accounting for its relative concentration in these fractions. The µm-sized heavy minerals are rutile, Fe-Ti- and Fe-oxides, zircon, pyrite, cassiterite, monazite and xenotime. Geochemical data indicate that most of the trace elements are relatively concentrated in clay-sized fractions, except for Zr, Hf, Y andHREE. Statistical treatment shows three different associations in the clay-sized fractions: (1) Rb, Cs and Ba with clay phyllosilicates, especially illite; (2)REEwith Th, Y and P phases; and (3) Sc, Cr and V with Ti- and Nb oxides. Therefore, these data do not support the dominantREEcontrol by clay mineralogy that other authors have reported.
First Italian occurrence of cumengéite from Vesuvius: crystal-structure refinement and revision of the chemical formula
Authors: Cruciani G. , Orlandi P. , Pasero M. , Russo M. 
Published: February 2006

AbstractThe first Italian occurrence of cumengéite, a rare Pb and Cu hydroxychloride, is described from Vesuvius (Italy). Italian cumengéite has a volcanic origin (it occurs in the fumarole), which is unique for that mineral. The mineralogy of Vesuvius' fumarole is outlined briefly. A powder X-ray diffraction (XRD) pattern of cumengéite is presented. The crystal structure of cumengéite has been refined (R= 0.036) using single-crystal XRD data. Cumengéite is tetragonal, space groupI4/mmm,a15.1007(2),c24.4940(4) Å. In the structure of cumengéite there are five independent Pb atoms, which are linked to 6—9 anions in five different ways. The structural study revealed the presence of two independent and previously unobserved water molecules, and led to the revision of the accepted chemical formula for the mineral: the new formula is Cu20Pb21Cl42(OH)40·6H2O. Analytical data taken from the literature for cumengéite from Boléo, Mexico (the type locality), as well as a new structural study carried out on the type material confirmed the new formula.
Aspidolite, the Na analogue of phlogopite, from Kasuga-mura, Gifu Prefecture, central Japan: description and structural data
Authors: Banno Y. , Miyawaki R. , Kogure T. , Matsubara S. , Kamiya T. , Yamada S. 
Published: February 2006

AbstractAspidolite, the Na analogue of phlogopite, ideally NaMg3AlSi3O10(OH)2, occurring in hornfels from a contact aureole in Kasuga-mura, central Japan, has been approved as a mica species by the Commission on New Minerals and Mineral Names of the International Mineralogical Association. Aspidolite is interleaved with and surrounded by phlogopite. Based on its mode of occurrence, phlogopite is classified into two types; (1) phlogopite interleaved with aspidolite (= interleaved phlogopite) and (2) phlogopite rim. The aspidolite-phlogopite assemblage is associated with amphibole (pargasite-magnesiosadanagaite), titanite, calcite, scapolite, apatite, pyrrhotite and chalcopyrite. A representative chemical formula of aspidolite is (Na0.90K0.10)∑1.00(Mg2.27Al0.41Fe0.232+Ti0.05)∑2.96 (Al1.44Si2.56)∑4.00O10(OH1.97F0.03)∑2.00. Aspidolite has almost fully occupied the interlayer site; its Na/(Na+K) ratio ranges from 0.67 to 0.95. It has more tetrahedral Al (1.38—1.48 a.p.f.u. for O = 11) than the ideal aspidolite end-member showing progression of tschermakite-type substitution. The alternation of aspidolite and phlogopite parallel to the (001) plane may indicate a miscibility gap between these two phases. The phlogopite rim is interpreted as a later product, probably formed metasomatically. Aspidolite is optically biaxial negative with elongation positive and Z ‖ cleavage. Two polytypes (1M and 1A) of aspidolite were identified in X-ray powder diffraction patterns. Aspidolite-1M is monoclinic, space group C2/m, with refined unit-cell parameters a = 5.291(8), b = 9.16(2), c = 10.12(2) Å, β = 105.1(1)°, V = 473(1) Å3, Z = 2. Aspidolite-1A is triclinic, space group C, with a = 5.289(6), b = 9.16(1), c = 9.892(9) Å, α = 94.45(9), β = 97.74(9), γ = 90.0(1)°, V = 473.4(9) Å3, Z = 2.