bluuebunny/crossref_metadata_2025_split huggingface dataset:
Piezoelectric Multi‐Channel Bilayer Transducer for Sensing and Filtering Ossicular Vibration
Authors: Yüksel Muhammed Berat , Atik Ali Can , Külah Haluk 
Published: February 2024

AbstractThis paper presents an acoustic transducer for fully implantable cochlear implants (FICIs), which can be implanted on the hearing chain to detect and filter the ambient sound in eight frequency bands between 250 and 6000 Hz. The transducer dimensions are conventional surgery compatible. The structure is formed with 3 × 3 × 0.36 mm active space for each layer and 5.2 mg total active mass excluding packaging. Characterization of the transducer is carried on an artificial membrane whose vibration characteristic is similar to the umbo vibration. On the artificial membrane, piezoelectric transducer generates up to 320.3 mVppunder 100 dB sound pressure level (SPL) excitation and covers the audible acoustic frequency. The measured signal‐to‐noise‐ratio (SNR) of the channels is up to 84.2 dB. Sound quality of the transducer for fully implantable cochlear implant application is graded with an objective qualification method (PESQ) for the first time in the literature to the best of the knowledge, and scored 3.42/4.5.
A Multifunctional Bimetallic Nanoplatform for Synergic Local Hyperthermia and Chemotherapy Targeting HER2‐Positive Breast Cancer
Authors: Zhao Li , Chang Fei , Tong Yao , Yin Jiawei , Xu Jiawen , Li Hui , Du Lutao , Jiang Yanyan 
Published: February 2024

AbstractAnti‐HER2 (human epidermal growth factor receptor 2) therapies significantly increase the overall survival of patients with HER2‐positive breast cancer. Unfortunately, a large fraction of patients may develop primary or acquired resistance. Further, a multidrug combination used to prevent this in the clinic places a significant burden on patients. To address this issue, this work develops a nanotherapeutic platform that incorporates bimetallic gold‐silver hollow nanoshells (AuAg HNSs) with exceptional near‐infrared (NIR) absorption capability, the small‐molecule tyrosine kinase inhibitor pyrotinib (PYR), and Herceptin (HCT). This platform realizes targeted delivery of multiple therapeutic effects, including chemo‐and photothermal activities, oxidative stress, and immune response. In vitro assays reveal that the HCT‐modified nanoparticles exhibit specific recognition ability and effective internalization by cells. The released PYR inhibit cell proliferation by downregulating HER2 and its associated pathways. NIR laser application induces a photothermal effect and tumor cell apoptosis, whereas an intracellular reactive oxygen species burst amplifies oxidative stress and triggers cancer cell ferroptosis. Importantly, this multimodal therapy also promotes the upregulation of genes related to TNF and NF‐κB signaling pathways, enhancing immune activation and immunogenic cell death. In vivo studies confirm a significant reduction in tumor volume after treatment, substantiating the potential effectiveness of these nanocarriers.
DNMT3A Cooperates with YAP/TAZ to Drive Gallbladder Cancer Metastasis
Authors: Xu Sunwang , Yuan Zhiqing , Jiang Cen , Chen Wei , Li Qiwei , Chen Tao 
Published: February 2024

AbstractGallbladder cancer (GBC) is an extremely lethal malignancy with aggressive behaviors, including liver or distant metastasis; however, the underlying mechanisms driving the metastasis of GBC remain poorly understood. In this study, it is found that DNA methyltransferase DNMT3A is highly expressed in GBC tumor tissues compared to matched adjacent normal tissues. Clinicopathological analysis shows that DNMT3A is positively correlated with liver metastasis and poor overall survival outcomes in patients with GBC. Functional analysis confirms that DNMT3A promotes the metastasis of GBC cells in a manner dependent on its DNA methyltransferase activity. Mechanistically, DNMT3A interacts with and is recruited by YAP/TAZ to recognize and access the CpG island within the CDH1 promoter and generates hypermethylation of the CDH1 promoter, which leads to transcriptional silencing of CDH1 and accelerated epithelial‐to‐mesenchymal transition. Using tissue microarrays, the association between the expression of DNMT3A, YAP/TAZ, and CDH1 is confirmed, which affects the metastatic ability of GBC. These results reveal a novel mechanism through which DNMT3A recruitment by YAP/TAZ guides DNA methylation to drive GBC metastasis and provide insights into the treatment of GBC metastasis by targeting the functional connection between DNMT3A and YAP/TAZ.
Wearable All‐Fabric Hybrid Energy Harvester to Simultaneously Harvest Radiofrequency and Triboelectric Energy
Authors: Kou Zhenghao , Zhang Chao , Yu Buyun , Chen Hao , Liu Zhenguo , Lu Weibing 
Published: February 2024

AbstractDistributed micro‐energy harvesting devices offer the flexibility, sustainability, and multi‐scenario applicability that will be critical to wearable electronic products in the Internet of Things. The radiofrequency and triboelectric (RF‐TE) hybrid energy harvester (HEH) concept and prototype is presented for the first time, to simultaneously capture the energy from ambient electromagnetic waves and biological motions. The proposed hybrid energy harvesting system consists of a wearable rectenna, a triboelectric nanogenerator (TENG), and a power management circuit (PMC). Among them, the all‐fabric rectenna exhibits good impedance matching characteristics in the ISM frequency. The flexible TENG unit can generate a maximum power density of 0.024 µW cm−2. The designed multifunctional fabric‐based PMC can considerably enhance the controllability of harvested hybrid energy. Additionally, a normalizable fabric circuit board quasi surface mount technology (FCB‐SMT) is proposed to integrate all modules on the same fabric substrate in one step, making the entire system superior mechanical robustness. The proposed wearable fabric‐based RF‐TE hybrid energy harvester is capable of successfully driving consumer electronics (such as sensors, watches, etc.). It provides a new energy solution strategy for self‐powered wearable electronic devices and is anticipated to encourage the efficient utilization of renewable energy.
Creation of Wood‐Based Hierarchical Superstructures via In Situ Growth of ZIF‐8 for Enhancing Mechanical Strength and Electromagnetic Shielding Performance
Authors: Ye Haoran , Wu Ying , Jin Xin , Wu Jiamin , Gan Lu , Li Jianzhang , Cai Liping , Liu Chuangwei , Xia Changlei 
Published: February 2024

AbstractGiven the escalating prevalence of electromagnetic pollution, there is an urgent need for the development of high‐performance electromagnetic interference (EMI) shielding materials. Herein, wood‐based electromagnetic shielding materials have gained significant popularity due to their exceptional performance as building materials. In this study, a novel wood‐based composite with electromagnetic shielding properties is developed. Through the in situ growth of zeolitic imidazolate framework‐8 (ZIF‐8) crystals on wood fibers, coupled with uniform integration of carbon nanotubes (CNTs), a multifunctional composite named ZIF‐8/Poplar‐CNT composite is synthesized via a one‐step thermoforming process. The incorporation of CNTs endows the composites with excellent EMI shielding effectiveness (EMI SE). Among these elements, despite ZIF‐8 crystals not possessing intrinsic electromagnetic shielding functionality, their distinctive dodecahedral structure proves adept at scattering and reflecting electromagnetic waves within the composites, further improving the electromagnetic shielding effect. Hence, the ZIF‐8/Poplar‐CNT composite (56.95 dB) has ≈10 dB higher EMI SE compared to that of the composites without ZIF‐8 crystals. Meanwhile, ZIF‐8 crystals endow the materials with excellent tensile strength (54.84 MPa, enhanced by 4 times). Moreover, the introduction of Zn2+ provides superior antibacterial properties. The potential applications of ZIF‐8/Poplar‐CNT composites extend to diverse areas such as building decoration, electronic products, and medical equipment.
Directing Fluorinated Solid Electrolyte Interphase by Solubilizing Crystal Lithium Fluoride in Aprotic Electrolyte for Lithium Metal Batteries
Authors: Fan Xiao‐Zhong , Zhang Jin‐Hao , Yao Nan , Chen Jin‐Xiu , Chen Xiang , Kong Long 
Published: February 2024

AbstractLithium fluoride (LiF) facilitates robust and fast‐ion‐transport solid electrolyte interphase (SEI) in lithium metal batteries. Fluorinated solvents/salts are ubiquitously employed to introduce LiF into SEI through electrochemical decomposition, but this approach is usually at the expense of their continuous consumption. A direct approach to fluorinate SEI that employs crystal LiF is limited by its poor solubility in the current battery electrolyte formulation. Dissolving crystal LiF in high‐dielectric‐constant solvents, like ethylene carbonate (EC) is nearly neglected. Herein, the feasibility of directly fluorinating SEI by the addition of crystal LiF in aprotic electrolyte with the assistance of EC is verified, and its mechanisms in fluorination of SEI and anti‐acidification of electrolyte are explored. The dissolved LiF is encapsulated by solvent‐/salt‐derived organic skins to promote the fluorinated SEI. Meanwhile, the presence of LiF in electrolyte alters hazardous thermodynamic equilibrium, suppressing the production of acid species to mitigate electrolyte acidification and SEI degradation. Such collective benefits yield a capacity retention ratio of ≈88% after 150 cycles at a high areal capacity (4.5 mAh cm−2) in Li||NCM622 cells. This facile and effective fluorination of SEI contributes to an in‐depth understanding of SEI formation and rational design of well‐performing lithium metal batteries.
A Highly Stable Practical Li Metal Anode via Interphase Regulation and Nucleation Induction
Authors: Xia Shuixin , Jiang Zongyan , Zhao Xiaoyu , Yuwono Jodie A. , Zhang Xun , Zhang Xiangfeng , Yang Guangzhi , Yang Junhe , Jiang Yong , Mao Jianfeng , Davey Kenneth , Guo Zaiping , Zheng Shiyou 
Published: February 2024

AbstractThe practical utilization of Li metal anodes has been significantly plagued by the challenges of uncontrollable dendritic Li growth and poor interphase instability. Here, the study reports a novel strategy to strengthen interphase and give highly efficient active seeds concurrently to stabilize Li metal via a highly lithiophilic In2O3 decorated porous scaffold. In situ configurated fast‐ion‐transport Li2O‐strengthened interphase layer cooperatively with highly efficient Li13In3 nucleation induction can endow the uniform Li nucleation/growth and high Li utilization efficiency. As a result, the achieved modified Li metal manifests high Coulombic efficiency, ultrahigh rate performance (5 mA cm−2), and ultra‐long lifespan cycling durability (7975 cycles). Importantly, the established Li|LiFePO4 cells exhibit long‐term cycling durability over 600 cycles at 1 C with an ultralow decay rate of ca. 0.017% per cycle. Moreover, the Li|LiCoO2 pouch cells with ultrahigh areal capacity of ca. 3.89 mAh cm−2 also exhibit extraordinarily prolonged cycling performance with excellent capacity retention despite extremely harsh cycling conditions of low negative‐to‐positive‐capacity (N/P) ratio of ca. 1.7 and lean electrolyte of ca. 4.9 g Ah−1. This work enlightens a facile and effective avenue toward highly stable Li metal anode toward reliable practicability.
Agronomic management response in maize (Zea maysL.) production across three agroecological zones of Kenya
Authors: Kipkulei Harison Kiplagat , Bellingrath‐Kimura Sonoko Dorothea , Lana Marcos , Ghazaryan Gohar , Baatz Roland , Matavel Custodio , Boitt Mark , Chisanga Charles B. , Rotich Brian , Moreira Rodrigo Martins , Sieber Stefan 
Published: February 2024

AbstractMaize (Zea maysL.) productivity in Kenya has witnessed a decline attributed to the effects of climate change and biophysical constraints. The assessment of agronomic practices across agroecological zones (AEZs) is limited by inadequate data quality, hindering a precise evaluation of maize yield on a large scale. In this study, we employed the DSSAT‐CERES‐Maize crop model (where CERES is Crop Environment Resource Synthesis and DSSAT is Decision Support System for Agrotechnology Transfer) to investigate the impacts of different agronomic practices on maize yield across different AEZs in two counties of Kenya. The model was calibrated and evaluated with observed grain yield, biomass, leaf area index, phenology, and soil water content from 2‐year experiments. Remote sensing (RS) images derived from the Sentinel‐2 satellite were integrated to delineate maize areas, and the resulting information was merged with DSSAT‐CERES‐Maize yield simulations. This facilitated a comprehensive quantification of various agronomic measures at pixel scales. Evaluation of agronomic measures revealed that sowing dates and cultivar types significantly influenced maize yield across the AEZs. Notably, AEZ II and AEZ III exhibited elevated yields when implementing combined practices of early sowing and cultivar H614. The impacts of optimal management practices varied across the AEZs, resulting in yield increases of 81, 115, and 202 kg ha−1in AEZ I, AEZ II, and AEZ III, respectively. This study underscores the potential of the CERES‐Maize model and high‐resolution RS data in estimating production at larger scales. Furthermore, this integrated approach holds promise for supporting agricultural decision‐making and designing optimal strategies to enhance productivity while accounting for site‐specific conditions.
Relative prognostic value of flow cytometric measurable residual disease before allogeneic hematopoietic cell transplantation for adults with MDS/AML or AML
Authors: Orvain Corentin , Ali Naveed , Othus Megan , Rodríguez‐Arbolí Eduardo , Milano Filippo , Le Calvin M. , Sandmaier Brenda M. , Scott Bart L. , Appelbaum Frederick R. , Walter Roland B. 
Published: February 2024

AbstractMultiparameter flow cytometry (MFC) measurable residual disease (MRD) before allogeneic hematopoietic cell transplantation (HCT) independently predicts poor outcomes in acute myeloid leukemia (AML). Conversely, its prognostic value in the newly defined disease entity, myelodysplastic neoplasm (MDS)/AML is unknown. To assess the relationship between disease type, pre‐HCT MRD, and post‐HCT outcomes, we retrospectively analyzed 1265 adults with MDS/AML (n = 151) or AML (n = 1114) who received a first allograft in first or second morphologic remission at a single institution between April 2006 and March 2023. At 3 years, relapse rates (29% for MDS/AML vs. 29% for AML, p = .98), relapse‐free survival (RFS; 50% vs. 55%, p = .22), overall survival (OS; 52% vs. 60%, p = .073), and non‐relapse mortality (22% vs. 16%, p = .14) were not statistically significantly different. However, a significant interaction was found between pre‐HCT MFC MRD and disease type (MDS/AML vs. AML) for relapse (p = .009), RFS (p = .011), and OS (p = .039). The interaction models indicated that the hazard ratios (HRs) for the association between pre‐HCT MRD and post‐HCT outcomes were lower in patients with MDS/AML (for relapse: HR = 1.75 [0.97–3.15] in MDS/AML vs. 4.13 [3.31–5.16] in AML; for RFS: HR = 1.58 [1.02–2.45] vs. 2.98 [2.48–3.58]; for OS: HR = 1.50 [0.96–2.35] vs. 2.52 [2.09–3.06]). On the other hand, residual cytogenetic abnormalities at the time of HCT were equally informative in MDS/AML as in AML patients. Our data indicate that MFC‐based pre‐HCT MRD testing, but not testing for residual cytogenetic abnormalities, is less informative for MDS/AML than AML patients when used for prognostication of post‐HCT outcomes.
Associations of Serum Insulin and Related Measures With Neuropathology and Cognition in Older Persons With and Without Diabetes
Authors: Arvanitakis Zoe , Capuano Ana W. , Tong Han , Mehta Rupal I. , Anokye‐Danso Frederick , Bennett David A. , Arnold Steven E. , Ahima Rexford S. 
Published: February 2024

ObjectiveTo examine associations of serum insulin and related measures with neuropathology and cognition in older persons.MethodsWe studied 192 older persons (96 with diabetes and 96 without, matched by sex and balanced by age‐at‐death, education, and postmortem interval) from a community‐based, clinical‐pathologic study of aging, with annual evaluations including neuropsychological testing (summarized into global cognition and 5 cognitive domains) and postmortem autopsy. We assessed serum insulin, glucose, leptin, adiponectin, hemoglobin A1C, advanced glycation‐end products (AGEs), and receptors for advanced glycation‐end products, and calculated the Homeostasis Model Assessment of Insulin Resistance (HOMA‐IR) and adiponectin‐to‐leptin ratio. Using adjusted regression analyses, we examined the associations of serum measures with neuropathology of cerebrovascular disease and Alzheimer's disease, and with the level of cognition proximate‐to‐death.ResultsHigher HOMA‐IR was associated with the presence of brain infarcts and specifically microinfarcts, and higher HOMA‐IR and leptin were each associated with subcortical infarcts. Further, higher leptin levels and lower adiponectin‐to‐leptin ratios were associated with the presence of moderate‐to‐severe atherosclerosis. Serum insulin and related measures were not associated with the level of Alzheimer's disease pathology, as assessed by global, as well as amyloid burden or tau tangle density scores. Regarding cognitive outcomes, higher insulin and leptin levels, and lower adiponectin and receptors for advanced glycation‐end products levels, respectively, were each associated with lower levels of global cognition.InterpretationPeripheral insulin resistance indicated by HOMA‐IR and related serum measures was associated with a greater burden of cerebrovascular neuropathology and lower cognition. ANN NEUROL 2024;95:665–676
Solvent Effects on Metal‐free Covalent Organic Frameworks in Oxygen Reduction Reaction
Authors: Yang Xiubei , Fu Yubin , Liu Minghao , Zheng Shuang , Li Xuewen , Xu Qing , Zeng Gaofeng 
Published: February 2024

AbstractBinding water molecules to polar sites in covalent organic frameworks (COFs) is inevitable, but the corresponding solvent effects in electrocatalytic process have been largely overlooked. Herein, we investigate the solvent effects on COFs for catalyzing the oxygen reduction reaction (ORR). Our designed COFs incorporated different kinds of nitrogen atoms (imine N, pyridine N, and phenazine N), enabling tunable interactions with water molecules. These interactions play a crucial role in modulating electronic states and altering the catalytic centers within the COFs. Among the synthesized COFs, the one with pyridine N atoms exhibits the highest activity, with characterized by a half‐wave potential of 0.78 V and a mass activity of 0.32 A mg−1, which surpass those from other metal‐free COFs. Theoretical calculations further reveal that the enhanced activity can be attributed to the stronger binding ability of *OOH intermediates to the carbon atoms adjacent to the pyridine N sites. This work sheds light on the significance of considering solvent effects on COFs in electrocatalytic systems, providing valuable insights into their design and optimization for improved performance.
Phosphate Coordination to Metal‐Organic Layer Secondary Building Units Prolongs Drug Retention for Synergistic Chemoradiotherapy
Authors: Luo Taokun , Jiang Xiaomin , Li Jinhong , Nash Geoffrey T. , Yuan Eric , Albano Luciana , Tillman Langston , Lin Wenbin 
Published: February 2024

AbstractChemoradiotherapy combines radiotherapy with concurrent chemotherapy to potentiate antitumor activity but exacerbates toxicities and causes debilitating side effects in cancer patients. Herein, we report the use of a nanoscale metal‐organic layer (MOL) as a 2D nanoradiosensitizer and a reservoir for the slow release of chemotherapeutics to amplify the antitumor effects of radiotherapy. Coordination of phosphate‐containing drugs to MOL secondary building units prolongs their intratumoral retention, allowing for continuous release of gemcitabine monophosphate (GMP) for effective localized chemotherapy. In the meantime, the MOL sensitizes cancer cells to X‐ray irradiation and provides potent radiotherapeutic effects. GMP‐loaded MOL (GMP/MOL) enhances cytotoxicity by 2‐fold and improves radiotherapeutic effects over free GMP in vitro. In a colon cancer model, GMP/MOL retains GMP in tumors for more than four days and, when combined with low‐dose radiotherapy, inhibits tumor growth by 98 %. The synergistic chemoradiotherapy enabled by GMP/MOL shows a cure rate of 50 %, improves survival, and ameliorates cancer‐proliferation histological biomarkers.
Precise Post‐Synthetic Modification of Heterometal‐Organic Capsules for Selectively Encapsulating Tetrahedral Anions
Authors: Lai Ya‐Liang , Xie Mo , Zhou Xian‐Chao , Wang Xue‐Zhi , Zhu Xiao‐Wei , Luo Dong , Zhou Xiao‐Ping , Li Dan 
Published: February 2024

AbstractPost‐synthetic modification plays a crucial role in precisely adjusting the structure and functions of advanced materials. Herein, we report the self‐assembly of a tubular heterometallic Pd3Cu6L16 capsule that incorporates Pd(II) and CuL1 metalloligands. This capsule undergoes further modification with two tridentate anionic ligands (L2) to afford a bicapped Pd3Cu6L16L22 capsule with an Edshammer polyhedral structure. By employing transition metal ions, acid, and oxidation agents, the bicapped capsule can be converted into an uncapped one. This uncapped form can then revert back to the bicapped structure on the addition of Br− ions and a base. Interestingly, introducing Ag+ ions leads to the removal of one L2 ligand from the bicapped capsule, yielding a mono‐capped Pd3Cu6L16L2 structure. Furthermore, the size of the anions critically influences the precise control over the post‐synthetic modifications of the capsules. It was demonstrated that these capsules selectively encapsulate tetrahedral anions, offering a novel approach for the design of intelligent molecular delivery systems.
Second Generation Catalytic Enantioselective Nucleophilic Desymmetrization at Phosphorus (V): Improved Generality, Efficiency and Modularity
Authors: Formica Michele , Ferko Branislav , Marsh Thomas , Davidson Timothy A. , Yamazaki Ken , Dixon Darren J. 
Published: February 2024

AbstractA broadly improved second generation catalytic two‐phase strategy for the enantioselective synthesis of stereogenic at phosphorus (V) compounds is described. This protocol, consisting of a bifunctional iminophosphorane (BIMP) catalyzed nucleophilic desymmetrization of prochiral, bench stable P(V) precursors and subsequent enantiospecific substitution allows for divergent access to a wide range of C‐, N‐, O‐ and S‐ substituted P(V) containing compounds from a handful of enantioenriched intermediates. A new ureidopeptide BIMP catalyst/thiaziolidinone leaving group combination allowed for a far wider substrate scope and increased reaction efficiency and practicality over previously established protocols. The resulting enantioenriched intermediates could then be transformed into an even greater range of distinct classes of P(V) compounds by displacement of the remaining leaving group as well as allowing for even further diversification downstream. Density functional theory (DFT) calculations were performed to pinpoint the origin of enantioselectivity for the BIMP‐catalyzed desymmetrization, to rationalize how a superior catalyst/leaving group combination leads to increased generality in our second‐generation catalytic system, as well as shed light onto observed stereochemical retention and inversion pathways when performing late‐stage enantiospecific SN2@P reactions with Grignard reagents.