bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Virtual Reality Game Training on Improving Walking Speed and Dynamic Balance Function After Stroke
Authors: Lampah Christopher 
Published: March 2024

Background: Stroke is a serious health condition that can cause physical and cognitive impairment, affecting a person's ability to perform daily activities. Important factor that affect the quality of life of stroke patients is the ability to mobilize, especially walking. Virtual Reality is expected to increase walking speed and dynamic balance which are important to improve patient mobility and independence.
Aim(s) : Analyse the effect of Virtual Reality (VR) game training using Xbox 360° and KinectTM devices on post-stroke walking speed and balance
Material and methods: An experimental study involving 18 ischemic post-stroke patients at the Rehabilitation Installation of Prof. Dr. R. D. Kandou Hospital Manado (from June to July 2023). The intervention was a 30 minutes VR game exercises with three sessions per week (a total of 8 sessions for each subject). This subject was assessed using the 10-meter Walk Test (10 MWT) and the Berg Balance Scale (BBS).
Result: There were significant improvements in both walking speed and dynamic balance. Wilcoxon Signed Ranks test results on Walking Speed (10 MWT) obtained a value of Z = -3,754 with a value of (p = 0.000 <0.05). Similar results were obtained in testing the dynamic balance function where the paired t test results were obtained at t = -14.750. The results indicate significant differences in the mean value of Subacute Post-Stroke BBS before and after training (p < 0.05).
Conclusions: Virtual Reality (VR) game training using Xbox 360° and KinectTM devices significantly increased walking speed and balance in post-stroke patients.
Circular RNA circNCOA3 promotes tumor progression and anti-PD-1 resistance in colorectal cancer
Authors: Chen Dong-Liang , Chen Nuo , Sheng Hui , Zhang Dong-Sheng 
Published: March 2024

Aim: Circular RNAs (circRNAs) have been found to be involved in tumor progression, but their role in colorectal cancer (CRC) immune escape remains to be elucidated.
Methods: circRNAs differentially expressed in responsive and resistant CRC tissues to programmed cell death 1 (PD-1) antibody therapy were identified by microarray analysis. The clinical and pathological significance of circNCOA3 was validated in a separate cohort of CRC samples. The function of circNCOA3 was explored experimentally. RNA immunoprecipitation and luciferase activity assays were conducted to identify downstream targets of circNCOA3.
Results: The circNCOA3 was markedly overexpressed in CRC samples resistant to PD-1 blockade. circNCOA3 expression was significantly correlated with adverse tumor phenotypes and poor outcomes in CRC patients. Knockdown of circNCOA3 expression markedly suppressed the proliferative and invasive capability of CRC cells. Moreover, knockdown of circNCOA3 increased the proportion of CD8+ T cells while decreasing the proportion of myeloid-derived suppressor cells (MDSCs). Knockdown of circNCOA3 inhibited tumor growth and increased the sensitivity to PD-1 antibody treatment in mouse tumor models. Further studies revealed that circNCOA3 acted as a competing endogenous RNA (ceRNA) for miR-203a-3p.1 to influence the level of CXCL1.
Conclusion: Our findings indicate that circNCOA3 might be useful as a potential biomarker to predict the efficacy and prognosis of CRC patients treated with anti-PD-1 therapy.
The Technology and Application of Hydroponic Vegetable Cultivation Systems Based on Solar Power Plants as an Effort to Fulfill Vegetable Needs Independently
Authors: Sunariyati Siti , Rasidah Rasidah , Wilson Jefriyanto , Pebriyanto Yunus 
Published: March 2024

The problems found at SMP Negeri 10 as the location of community service are that the condition of the land is less fertile, there is a lack of knowledge and skills regarding cultivation using a hydroponic system, and it is located in a remote area so that the vegetables consumed have always been imported from Palangka Raya City with a travel time of 1.5 hours by land and river. Electricity blackouts often occur in this area, which is quite disruptive to residents' activities. The solution to overcoming the problem is to use a hydroponic farming system that uses alternative electrical energy from solar power plants (PLTS). PLTS can be used as an alternative electrical energy source to run a hydroponic system. This PLTS was chosen because the Central Kalimantan region is a tropical area that effectively absorbs sunlight. This community service activity (PkM) aims to increase high school students' knowledge, skills, and interest in modern vegetable cultivation. The PkM team creates a guidebook to aid in the operation of hydroponic cultivation and the PLTS system, integrating training activities into project-based Merdeka Belajar activities during the implementation of community service. Monitoring and evaluation were carried out regularly until after the harvest period, and the results showed that student understanding increased to the medium-high category and attracted student interest to the excellent category.
Strengthening Teacher Competencies in the Era of Independent Curriculum through the Implementation of Change Management
Authors: Komariyah Laili , Sulaeman Nurul Fitriyah , Nuryadin Atin 
Published: March 2024

: This community service aimed to strengthen teachers' competencies in dealing with curriculum changes from the 2013 curriculum to the independent curriculum through training in the application of change management. This service activity is carried out using an asset-based community development (ABCD) approach, strengthening participants' potential for responding to change. The training participants were 35 elementary school teachers in Samarinda City. Training activities were conducted at SD Negeri 007 Samarinda Ulu, Samarinda City. This activity was carried out on Saturday, July 29, 2023. The activities involved providing training to strengthen teacher competencies by explaining the application of change management in dealing with curriculum changes. Data on training outcomes were obtained through the Teacher Attitudes Towards Change Scale (TATCS) questionnaire and questions regarding participants' perceptions of the training. Participants' answers were analyzed using keywords and word co-occurrence analyses. The training strengthened teacher competence in the era of an independent curriculum by increasing teacher belief in the importance of curriculum change, confidence in applying the Merdeka curriculum, and support for curriculum change. These results indicate the urgency of conducting similar training periodically to strengthen teacher competence in the adaptation process using an independent curriculum.
Analysis of Hydraulic Axle Leak in Toothpaste Mixing Machine at PT. Miswak Utama
Authors: Sahroni Rizki Arif Maulana 
Published: March 2024

Field Work Practice is one of the courses contained in the Mechanical Engineering Study Program that learns about how we do work and adapt to the industrial world at this time. Mixer is one of the mixing tools in the emulsion system so that it produces a uniform or homogeneous dispersion. The problem of hydraulic axle leakage of the mixing machine that often occurs and becomes a serious problem that can cause the engine to not operate, which requires maintenance/repair for a long time, There is an oil leak in the hydraulic piston system on the mixing machine which causes the piston to not be able to rise and turn perfectly which causes the tank lid of the mixing machine to not be able to hit the tightness so that it delays the production process. To prevent damage to the mixing machine which directly results in smooth production, maintenance and periodic checks are needed. Because the mixing machine itself plays an important role in the process of making toothpaste, therefore if the mixing machine experiences Damage will cause harm to the company itself
(Keyword : Mixing Enggine, Hidrolist oil,seal)
HAK ASASI MANUSIA DAN TANGGAPAN ISLAM TERHADAPNYA
Authors: Jamal Jamal , Kusuma Amir Reza 
Published: March 2024

Hak asasi manusia (HAM) sebagai hak dasar yang dimiliki manusia sejak manusia dilahirkan menjadi suatu jaminan sosial dan politik untuk melindungi harkat martabat individu dari ancaman, serta mencapai kebenaran, kebebasan, keadilan, persamaan dan lain sebagainya. Penjabaran konsep HAM dan kata ‘universal’ pertama kali muncul di Majelis Umum PBB pada Tahun 1948 melalui Deklarasi Universal Hak Asasi Manusia (DUHAM). Funginya sebagai sebuah standar kebaikan bersama bagi pencapaian semua bangsa dan negara. Dengan demikian deklarasi DUHAM untuk mencapai nilai-nilai moral kemanusiaan dalam menentukan standar baik-buruk kehidupan individu dan masyarakat di setiap negara.
Non-Reference Enhanced Low-Light Image Estimation Using Zero-DCE with Filtering Refinement.
Authors: Maloth Vijaya , Jatoth Ravi Kumar 
Published: March 2024

Abstract
This paper introduces Modified Zero-Reference Deep Curve Estimation (Zero-DCE), a novel technique that treats light enhancement as image-specific curve estimation task using a deep curve network. Our network, powered by DCE-Net, trains a light-weight deep network to estimate pixel-wise and higher order curves, facilitating dynamic range adjustment in an images. The design of our curve estimation network prioritizes considerations such as pixel value range, differentiability, and monotonicity. An intriguing aspect of modified Zero-DCE lies in its departure from strict requirements on the reference images. It doesn't rely on unpaired or paired data during training. Instead, it leverages a set of meticulously crafted the non-reference loss functions. These loss functions implicitly evaluate image enhancement quality and guide the network's learning process. Despite its simplicity, our method demonstrates robust generalization across the diverse lighting conditions. To further refine enhanced images generated through this network, a post-processing step involves filtering to eliminate noise that emerges after transforming the low-light images into high-light ones. This noise reduction step significantly enhances images, resulting in remarkable improvements in SSIM (Structural Similarity Index) and PSNR (Peak Signal-to-Noise Ratio) metrics when comparing the de-noised enhanced images to their high-light images.
Influential factors and outcome of high-risk keratoplasty in a tertiary referral corneal center – a retrospective study
Authors: Aschauer Julia , Klimek Michal , Donner Ruth , Lammer Jan , Steiner Irene , Schmidinger Gerald 
Published: March 2024

Abstract

Background
Corneal allograft survival is decreased in high-risk (HR) host beds.
The purpose of this study was to investigate the outcome of HR keratoplasty (KP) in a single-center tertiary referral clinic, and to determine risk factors for graft failure.
Methods
This retrospective study included adult patients referred for HR penetrating KP between 2014 and 2022. High-risk criteria were history of re-KP, significant stromal neovascularization, and inflammation/perforation at time of surgery.
Donor endothelial cell count/age, stromal neovascularization, and perforation/acute inflammation at surgery were independent variables in the logistic regression models for the first year after KP with graft failure as primary endpoint.
Results
Graft survival 1 year after surgery was 56.2% (CI: 45.7, 66.4), 68.3% (CI: 59.3, 76.4), and 70.2% (CI: 56.6, 81.6) after the first, second, and third KP, respectively. Perforation/acute inflammation at surgery was independently associated with graft failure, which occurred in 190 (51%) of 375 KPs (257 patients). The median time (95% CI) from KP until graft failure was 559 (392, 994), 1052 (833, 1375), and 1089 (689, inf) days for the 1st, 2nd, 3rd KP, respectively. The most frequent cause for failure was immune rejection (29%), with a majority (35%) of graft failures remaining undefined.
Conclusions
Acute inflammation/perforation at the time of surgery were the major risk factors for graft failure in HR KP. We confirm reduced survival rates for HR KPs, which highlights the persistent need for further developments in individualized treatments in this patient population.
Mild ovarian stimulation using the aromatase inhibitor letrozole (LTZ) is a good stimulation protocol for to obtain euploid blastocysts for advanced maternal age women.
Authors: NAKAGAWA KOJI , Horikawa Takashi , Shiobara Kesuke , Ishiyama Shunsuke , Kataoka Hisayo , Nakao Katsuki , Ojiro Yuko , Kuoda Keiji , Takamizawa Satoru , Sugiyama Rikikazu , Shiobara Kesuke , Kuoda Keiji 
Published: March 2024

Abstract
Purpose:
Mild ovarian stimulation (MOS) is an effective form of assisted reproductive technology (ART) for advanced maternal age (AMA) women. Taking either clomiphene (CC) or letrozole (LTZ) with MOS reduces the amount of gonadotropin that must be used. It has remained uncertain, however, whether LTZ or CC is more effective in combination with MOS. Therefore, we evaluated the choice of combination either CC or LTZ with MOS and quantified the obtainment of euploid blastocysts for AMA women.
Methods
This retrospective study was conducted between January 2020 and April 2021. In this study, we stimulated 286 women with MOS, 153 of these women used CC (CC group) and 133 were given LTZ (LTZ group). All women took either 100 mg of CC or 5 mg of LTZ daily for 7 days between MC 3 and MC 9, and 225 IU of recombinant-FSH were administered on MC 3, MC 5, MC 7, and MC 9. The euploid rates were compared between these two groups. Among them, the women who were ≥ 40 years old were divided into two groups, CC-O40 group (n = 61) and LTZ-O40 group (n = 54), and the euploid rates were evaluated.
Results:
For AMA women, the blastocyst formation rate in the LTZ-O40 group (58.5%) was significantly higher than that in the CC-O40 group (46.6%, P < 0.05). The euploid rate in the LTZ group was 53.4%, which was significantly higher than that in the CC group (38.0%, P < 0.05). The AMA euploid rate in the LTZ-O40 group was 40.5%, which also was significantly higher than that in the CC-O40 group (16.7%, P < 0.05).
Conclusions
For AMA women, a regimen of LTZ combined with MOS is the most effective ovarian stimulation method for obtaining euploid blastocysts.
Evaluating different methods for kidney recellularization
Authors: Luque-Badillo Ana C. , Monjaras-Avila Cesar U. , Adomat Hans , So Alan , Chavez-Munoz Claudia 
Published: March 2024

Abstract

This study explores a potential solution to the shortage of kidneys for transplantation in end-stage renal disease (ESRD). Currently, kidney transplantation is the best option, but there aren't enough organs available. The researchers used tissue engineering to evaluate the possibility for creating kidneys for transplantation. They used pig kidneys, removing cells through a process called decellularization while preserving the organ's microarchitecture. The researchers then perfused pig kidney cells and human red blood cells to the empty kidney structure to recreate it. The methodologies used, showed promising results, suggesting a hopeful method to address the organ shortage. This proof-of-concept lays the foundation for potentially applying this technology to human kidneys, which could significantly improve outcomes for ESRD patients by providing more transplantable organs.
First demonstration of reconfigurable and low-power strong physical unclonable function empowered by FeFET cycle-to-cycle variation
Authors: Li Xueqing , Guo Xinrui , Li Taixin , Müller Franz , Abdulazhanov Sukhrob , Ma Xiaoyang , Zhong Hongtao , Liu Yongpan , Narayanan Vijaykrishnan , Yang Huazhong , Ni Kai , Kämpfe Thomas 
Published: March 2024

Abstract

Physical unclonable functions (PUFs) are of immense potential in authentication applications for numerous Internet of Things (IoT) devices. For creditable and lightweight PUF applications, high reconfigurability, ultra-low power, and large challenge-response pair (CRP) space are highly desirable. Here we report the first demonstration of ferroelectric field-effect transistor (FeFET)-based strong PUF with high reconfigurability and energy efficiency. Unlike prior works, for the first time, we utilize the FeFET cycle-to-cycle variation all around and the unique charge-domain in-memory computing to empower excellent performances. The proposed 2FeFET-1C PUF cell is fabricated using 28nm HKMG technology for verification. Experimental measurements performed on integrated FeFET arrays reveal excellent uniformity, uniqueness, and repeatability. Remarkably, our PUF achieves near-ideal reconfigurability (HDreconfig, 50.02%) and ultra-low 4.014fJ/bit readout energy, significantly outperforming the state-of-the-art designs. Furthermore, we show that the PUF can operate with high robustness and provide almost unpredictable resilience against machine learning (ML) attacks. These superior performances demonstrate the great promise of the first FeFET-based strong PUF in practical IoT edge-side security solutions.
Carbapenem or colistin resistant Klebsiella pneumoniae bacteremia in the intensive care unit: real life data
Authors: Semet Cihan , Efe Kadir , Akalın Halis , İşçimen Remzi , Girgin Nermin Kelebek , Özakın Cüneyt , Kahveci Ferda 
Published: March 2024

Abstract

Carbapenem-resistant Klebsiella pneumoniae (CRKp) infections continue to be an important cause of morbidity and mortality.
In this study, the effect of carbapenem or colistin resistance on mortality in Klebsiella pneumoniae bacteremia and combined meropenem + colistin administration in CRKp bacteremia was retrospectively evaluated.
A total of 139 adult patients diagnosed with K. pneumoniae bacteremia(73 carbapenem sensitive and 66 carbapenem resistant) were included in the study. The 30-day mortality in entire cohort were 19.4%.
30-day mortality was significantly higher in the carbapenem resistant-colistin sensitive group and in the carbapenem resistant-colistin resistant group compared to the carbapenem susceptible (ESBL positive) group.
Meropenem + colistin combination was administered to 37 (95%) of carbapenem resistant–colistin sensitive (n=39) and 25 (93%) of carbapenem resistant–colistin resistant patients(n=27). Notably, mortality was not significantly affected regardless of whether CRKp was colistin sensitive and whether a high dose and prolonged infusion of meropenem was administered.
Mortality is higher in carbapenem resistant Klebsiella pneumoniae bacteremia compared to carbapenem susceptible group. In cases of combined meropenem and colistin administration, high dose and prolonged infusion of meropenem is not superior to standard dose and infusion in both carbapenem resistant–colistin sensitive and carbapenem resistant–colistin resistant K. pneumoniae bacteremia.
Determinants of Healthcare costs in individuals with Down syndrome: A systematic review
Authors: ToloueiRakhshan Shiva , Byford Sarah , RaziMoghadam Mahya , Moradi Fardin , Soltani Shahin 
Published: March 2024

Abstract
Background: Individuals with Down Syndrome (DS) are more likely than their non-disabled counterparts to require specialized follow-up and medical services, resulting in high healthcare and other costs for families and health systems. This systematic review intended to examine the costs and the determinants of costs for individuals with DS.
Methods: For this systematic review, we searched Web of Science, PubMed, and Scopus from 2000 to 2022 for observational or experimental studies reporting the costs of DS or factors influencing these costs for individuals with DS. Reference lists of identified articles were also searched for additional studies. Non-English language articles, duplicates, abstracts, qualitative research, gray literature, and non-original papers (e.g., letter to the editor, editorial, reviews, etc.), were excluded.
Result: The search identified 625 unique citations, of which 14 matched the inclusion criteria. Half the studies (n=7; 50%) were conducted in the United States. Inpatient services accounted for the largest proportion of total health care costs, according to 58% of included studies. Twenty five percent of studies identified economic losses to the families of individuals with DS as a result of productivity losses (time off work or out of work in order to care for the individual with DS). Health care costs and age correlate positively or negatively among individuals with DS throughout their lifetime.
Moreover, associated morbidities, functional limitations, and a lower socioeconomic status were related to higher costs.
Conclusions: This systematic review identified several characteristics, including age, comorbidities, and lower socioeconomic status, contributing to the greater healthcare cost associated with DS. These results suggest establishing a long-term, all-encompassing policy for medical and social welfare programs in collaboration with stakeholders and monitoring and targeting co-morbidities and support schemes for families most affected by indirect costs/losses could compensate both direct and indirect costs of DS on families and society.
Comparison of Sargassum community succession between artificial and natural reefs in Wakasa Bay, Japan
Authors: Matsui Akira , Kawamura Masakatsu , Nozawa Shigehiro , Takeyama Masatomo , Inoue Naoya 
Published: March 2024

Abstract

The threat of declining seaweed beds has been a concern around the world. Seagrass and seaweed (brown algae) beds are essential habitats supporting fisheries. However, approximately 22% of these habitats have been lost in Japan due to increased coastal landfill sites and ports. This study aims to rehabilitate the depletion of these habitats by constructing an artificial reef in Wakasa Bay, Japan, and monitoring brown algae (Sargassum sp.) succession in 1 year and 3 years after the reef construction. In this study, we set up six sites on the artificial reef as a treatment area and three sites on the natural reef as a control area and then identified the seaweed species composition of the Sargassum community and their coverage on each reef using underwater visual observation by scuba divers. Significant differences between the artificial and natural reefs were identified. The seaweed species composition and coverage of the Sargassum community on the artificial reef differed from those on the natural reef in 3 years after the reef construction. On the artificial reef, the presence of S. horneri decreased and that of S. hemiphyllum/S. patens increased, whereas on the natural reef, S. patens dominated and S. macrocarpum increased. The seaweed species composition and coverage on the artificial reef had not caught up with those on the natural reef. The seaweed on the artificial reef is thus considered to be in the vegetation succession process, which has not yet reached the climax condition, while the natural reef has almost reached the climax phase. The Sargassum community monitoring on the artificial reef appears necessary to be continued in the next few years.