bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does preterm birth increase the initiation of antidepressant use during the postpartum? A population-based investigation
Authors: Esposito Giovanna , Cantarutti Anna , Lupattelli Angela , Franchi Matteo , Corrao Giovanni , Parazzini Fabio 
Published: March 2024

Background:Preterm birth may affect maternal mental health. We explored the relationship between preterm birth and the risk of initiating antidepressant use during the year after birth.Methods:We conducted a population-based investigation using regional healthcare utilization databases. The exposure considered was preterm birth. The outcome was having at least one prescription for antidepressant medications during the year after birth. We used a log-binomial regression model including terms for maternal age at birth, nationality, educational level, parity, modality of conception, modality of delivery, use of other psychotropic drugs, and diabetes to estimate relative risk (RR) and 95% confidence intervals (CI) for the association between preterm birth and the initiation of antidepressant use. In addition, the absolute risk differences (ARD) were also computed according to the timing of birth.Results:The cohort included 727,701 deliveries between 2010 and 2020 in Lombardy, Northern Italy. Out of these, 6,522 (0.9%) women had at least one prescription for antidepressant drugs during the year after birth. Preterm births were related to a 38% increased risk of initiation of antidepressant use during the year after birth (adjusted RR = 1.38; 95% CI: 1.25–1.52) for moderate to late preterm and to 83% (adjusted RR = 1.83; 95% CI: 1.46–2.28) for extremely and very preterm. Excluding women with only one antidepressant prescription, the association was consistent (adjusted RR = 1.41, 95%CI: 1.23–1.61 for moderate to late preterm and adjusted RR = 1.81, 95% CI: 1.31–2.49 for extremely and very preterm). Also, excluding women who used other psychotropics, the association remained consistent (adjusted RR = 1.39, 95%CI: 1.26–1.54 and adjusted RR = 1.91, 95% CI: 1.53–2.38, respectively for moderate to late and extremely and very preterm).Conclusion:Women who delivered preterm may have an excess risk of initiation of antidepressant consumption during the first year after birth.
A deep semantic network-based image segmentation of soybean rust pathogens
Authors: Wu Yalin , Xi Zhuobin , Liu Fen , Hu Weiming , Feng Hongjuan , Zhang Qinjian 
Published: March 2024

IntroductionAsian soybean rust is a highly aggressive leaf-based disease triggered by the obligate biotrophic fungus Phakopsora pachyrhizi which can cause up to 80% yield loss in soybean. The precise image segmentation of fungus can characterize fungal phenotype transitions during growth and help to discover new medicines and agricultural biocides using large-scale phenotypic screens.MethodsThe improved Mask R-CNN method is proposed to accomplish the segmentation of densely distributed, overlapping and intersecting microimages. First, Res2net is utilized to layer the residual connections in a single residual block to replace the backbone of the original Mask R-CNN, which is then combined with FPG to enhance the feature extraction capability of the network model. Secondly, the loss function is optimized and the CIoU loss function is adopted as the loss function for boundary box regression prediction, which accelerates the convergence speed of the model and meets the accurate classification of high-density spore images.ResultsThe experimental results show that the mAP for detection and segmentation, accuracy of the improved algorithm is improved by 6.4%, 12.3% and 2.2% respectively over the original Mask R-CNN algorithm.DiscussionThis method is more suitable for the segmentation of fungi images and provide an effective tool for large-scale phenotypic screens of plant fungal pathogens.
Fostering quality of life in young adults living with multiple sclerosis: a pilot study of a co-created integrated intervention
Authors: Poli Silvia , Donisi Valeria , Mazzi Maria Angela , Gobbin Francesca , Giusto Giorgia , Orlandi Riccardo , Schena Federico , Del Piccolo Lidia , das Nair Roshan , Gajofatto Alberto , Rimondini Michela 
Published: March 2024

IntroductionMultiple sclerosis (MS) is generally diagnosed at an early age, making the acceptance of this chronic disease challenging. Research dedicated to young adults with MS (YawMS) is still limited. A biopsychosocial co-created intervention for YawMS integrating social, physical and psychological activities was developed (ESPRIMO intervention) in order to improve the quality of life (QoL) and well-being. This pre-post intervention assessment study examines the feasibility of the ESPRIMO intervention and its signal of efficacy.MethodsInclusion criteria were: age 18–45 years, MS diagnosis, Expanded Disability Status Scale score &lt; 3.5. After giving informed consent, YawMS completed a battery of questionnaires, which was repeated after the intervention. The battery included a bespoke feasibility scale, the COOP/WONCA charts, and the Short Form-12 Health Survey (SF-12).ResultsFifty-three YAwMS were enrolled and 43 (81.1%) completed the intervention. The majority of the sample positively rated the pleasantness, usefulness and feasibility of the intervention. A significant change in the COOP/WONCA “general QoL” chart (t = 3.65; p &lt; 0.01) and SF-12 mental wellbeing component (t = −3.17; p &lt; 0.01) was found.DiscussionESPRIMO is an innovative intervention that is feasible; preliminary results show an improvement in QoL and mental wellbeing. Further studies are needed to test its efficacy and evaluate future implementation in health services.Clinical trial registration: ClinicalTrials.gov, NCT04431323.
Parvalbumin interneuron deficiency in the prefrontal and motor cortices of spontaneously hypertensive rats: an attention-deficit hyperactivity disorder animal model insight
Authors: Bogdańska-Chomczyk Ewelina , Równiak Maciej , Huang Andrew Chih-Wei , Kozłowska Anna 
Published: March 2024

BackgroundAttention deficit hyperactivity disorder (ADHD) is characterized by impairments in developmental–behavioral inhibition, resulting in impulsivity and hyperactivity. Recent research has underscored cortical inhibition deficiencies in ADHD via the gamma-aminobutyric acid (GABA)ergic system, which is crucial for maintaining excitatory–inhibitory balance in the brain. This study explored postnatal changes in parvalbumin (PV) immunoreactivity, indicating GABAergic interneuron types, in the prefrontal (PFC) and motor (MC) cortices of spontaneously hypertensive rats (SHRs), an ADHD animal model.MethodsExamining PV- positive (PV+) cells associated with dopamine D2 receptors (D2) and the impact of dopamine on GABA synthesis, we also investigated changes in the immunoreactivity of D2 and tyrosine hydroxylase (TH). Brain sections from 4- to 10-week-old SHRs and Wistar Kyoto rats (WKYs) were immunohistochemically analyzed, comparing PV+, D2+ cells, and TH+ fiber densities across age-matched SHRs and WKYs in specific PFC/MC regions.ResultsThe results revealed significantly reduced PV+ cell density in SHRs: prelimbic (~20% less), anterior cingulate (~15% less), primary (~15% less), and secondary motor (~17% less) cortices. PV+ deficits coincided with the upregulation of D2 in prepubertal SHRs and the downregulation of TH predominantly in pubertal/postpubertal SHRs.ConclusionReduced PV+ cells in various PFC regions could contribute to inattention/behavioral alterations in ADHD, while MC deficits could manifest as motor hyperactivity. D2 upregulation and TH deficits may impact GABA synthesis, exacerbating behavioral deficits in ADHD. These findings not only shed new light on ADHD pathophysiology but also pave the way for future research endeavors.
Association between physical activity and health-related quality of life among adults in China: the moderating role of age
Authors: Hao Hongying , Yuan Yemin , Li Jie , Zhao Dan , Li Peilong , Sun Jingjie , Zhou Chengchao 
Published: March 2024

ObjectiveThe aim of the study was to examine the association between physical activity (PA) and health-related quality of life (HRQOL) among adults and explore the role of age in the association between PA and HRQOL in Shandong, China.MethodsWe investigated the relationship between PA and HRQOL and examined the moderated role of age in this association among adults with different age groups and physical activity levels. Data were obtained from the sixth China National Health Services Survey conducted in Shandong province in 2018. The multi-stage-stratified cluster random sampling method was used to selected respondents, with individuals aged 18 and above included in the present study. The tool of assessing HRQOL was the three-level EuroQol Five Dimensions Questionnaire (EQ-5D-3L).ResultsThe study found PA was significantly related to HRQOL (P&lt; 0.05). The interaction analysis indicated that the relationship between PA and HRQOL was significantly different across young, middle-aged, and older adults (P&lt; 0.05). Older adults with the sufficient PA (coefficient = 0.090, 95%CI: [0.081, 0.100]) and active PA (coefficient = 0.057, 95%CI: [0.043, 0.072]) had significantly higher HRQOL compared with young and middle-aged groups.ConclusionPA was positively associated with HRQOL among the adults. Age played a moderate role between the association between PA and HRQOL. Guidelines for PA should be specifically tailored to adults of different age groups in order to enhance their HRQoL.
Establishing a screening strategy for non-discriminatory reactive blood donors by constructing a predictive model of hepatitis B virus infection status from a single blood center in China
Authors: Wu Danxiao , Hu Yiqin , Wang Min , Wu Yaling , Dong Jie , Liu Jinhui , Hu Wei 
Published: March 2024

BackgroundWhen employing the transcription-mediated amplification method for screening blood donors, there are some non-discriminatory reactive results which are screening assay reactive but HBV-DNA discriminatory assay negative. This raises concerns regarding the possibility of false positives among donors, which may lead to permanent deferral of blood donors and affect blood supply. This study aimed to elucidate the infection status of these non-discriminatory reactive blood donors and develop and validate a model to predict individualized hepatitis B status to establish an optimal screening strategy.MethodsSupplementary tests were conducted on initial non-discriminating reactive donations to determine their HBV infection status, including repeat testing, viral load, serological marker detection, and follow-up. Primary clinical variables of the donors were recorded. Based on the Akaike information criterion, a stepwise forward algorithm was used to identify the predictive factors for information and construct a predictive model. The optimal screening strategy was determined through cost-effectiveness analysis.ResultsAt the Blood Center of Zhejiang Province, 435 cases of initial non-discriminatory reactive donations were collected over two successive periods and sub-categorized through repeated testing into the following three groups: non-repeated positive group, non-discriminated positive group, and non-repeated HBV-DNA positive group. The HBV discriminatory rate increased after repeated testing (110/435, 25.29%). According to supplementary tests, the HBV-DNA positivity rate was 65.52% (285/435), and occult HBV infection was a significantly different among groups (χ2 = 93.22, p &lt; 0.01). The HBV serological markers and viral load in the non-repeated positive group differed from those in the other two groups, with a lower viral load and a higher proportion of false positives. The predictive model constructed using a stepwise forward algorithm exhibited high discrimination, good fit, high calibration, and effectiveness. A cost-effectiveness analysis indicated that utilizing repeated discriminatory testing and the predictive model is an extremely beneficial screening approach for non-discriminatory reactive blood donors.ConclusionNearly two-third (65.52%) of the non-discriminatory reactive blood donors were HBV-DNA positive. Our innovative approach of constructing a predictive model as a supplementary screening strategy, combined with repeated discriminatory experiments, can effectively identify the infection status of non-discriminatory reactive blood donors, thereby increasing the safety of blood transfusions.
Outcomes of balloon angioplasty and stent placement for iliac artery lesions classified as TASC II A, B: a single-center study
Authors: Duc Tin Le , Van Nut Lam , Abdalla Abdelrahman Sherif , Duc Hoang , Kwaah Patrick A. , Le Trang T. B. , Vy Tran Thi Thuy , Le Thoa , Anh Pham Minh , Kim Que Do , Huy Nguyen Tien 
Published: March 2024

BackgroundIliac artery stenosis or occlusion is a critical condition that can severely impact a patient's quality of life. The effectiveness of balloon angioplasty and intraluminal stenting for the treatment of iliac artery lesions classified as TASC II A and B was evaluated in this single-center prospective study.MethodsConducted between October 2016 and September 2020 at Cho Ray Hospital's Vascular Surgery Department, this prospective study involved PAD patients categorized by TASC II A and B classifications who underwent endovascular intervention. Intervention outcomes were assessed peri-procedure and during short-term and mid-term follow-ups.ResultsOf the total of 133 patients, 34.6% underwent balloon angioplasty, while 65.4% received stenting. The immediate technical success rate was 97.7%, while the clinical success rate was 62.4%. Complications were minimal, with major limb amputation reported in 1.5% of the cases. There was a significant improvement in Rutherford classification and ABI at short-term follow-up, with a patency rate of 90.2%. The mid-term post-intervention follow-up yielded similar results with an 86.1% patency rate. The mortality rates associated with arterial occlusion were 2.3% during short-term follow-up and 1.7% during mid-term follow-up.ConclusionBalloon angioplasty and stent placement are effective and safe interventions for TASC II A and B iliac artery occlusions with favorable short and mid-term outcomes. Further, multi-center studies with larger sample sizes are recommended for more comprehensive conclusions, including long-term follow-up assessment.
Cytokine profile in peripheral blood mononuclear cells differs between embryo donor and potential recipient sows
Authors: Cambra Josep M. , Gil Maria A. , Cuello Cristina , Gonzalez-Plaza Alejandro , Rodriguez-Martinez Heriberto , Klymiuk Nikolai , Martinez Emilio A. , Parrilla Inmaculada 
Published: March 2024

IntroductionPregnancy success relies on the establishment of a delicate immune balance that requires the early activation of a series of local and systemic immune mechanisms. The changes in the immunological profile that are normally occurring in the pregnant uterus does not take place in cyclic (non-pregnant) uterus, a fact that has been widely explored in pigs at the tissue local level. Such differences would be especially important in the context of embryo transfer (ET), where a growing body of literature indicates that immunological differences at the uterine level between donors and recipients may significantly impact embryonic mortality. However, whether components of peripheral immunity also play a role in this context remains unknown. Accordingly, our hypothesis is that the immune status of donor sows differs from potential recipients, not only at the tissue local level but also at the systemic level. These differences could contribute to the high embryonic mortality rates occurring in ET programs.MethodsIn this study differences in systemic immunity, based on cytokine gene expression profile in peripheral blood mononuclear cells (PBMCs), between embryo-bearing donor (DO group; N = 10) and potential recipient sows (RE group; N = 10) at Day 6 after the onset of the estrus were explored. Gene expression analysis was conducted for 6 proinflammatory (IL-1α, IL-1β, IL-2, GM-CSF, IFN-γ, and TNF-α) and 6 anti-inflammatory (IL-4, IL-6, IL-10, IL-13, TGF-β1, and LIF) cytokines.Results and discussionAll cytokines were overexpressed in the DO group except for IL-4, suggesting that stimuli derived from the insemination and/or the resultant embryos modify the systemic immune profile in DO sows compared to RE (lacking these stimuli). Our results also suggest that certain cytokines (e.g., IL-1α and IL-1β) might have a predictive value for the pregnancy status.
Quantum Implementation of AIM: Aiming for Low-Depth
Authors: Jang Kyungbae , Oh Yujin , Kim Hyunji , Seo Hwajeong 
Published: March 2024

Security vulnerabilities in the symmetric-key primitives of a cipher can undermine the overall security claims of the cipher. With the rapid advancement of quantum computing in recent years, there is an increasing effort to evaluate the security of symmetric-key cryptography against potential quantum attacks. This paper focuses on analyzing the quantum attack resistance of AIM, a symmetric-key primitive used in the AIMer digital signature scheme. We present the first quantum circuit implementation of AIM and estimate its complexity (such as qubit count, gate count, and circuit depth) with respect to Grover’s search algorithm. For Grover’s key search, the most important optimization metric is depth, especially when considering parallel search. Our implementation gathers multiple methods for a low-depth quantum circuit of AIM in order to reduce the Toffoli depth and full depth (such as the Karatsuba multiplication and optimization of inner modules; Mer, LinearLayer).
Fuzzy Neural Network PID-Based Constant Deceleration Control for Automated Mine Electric Vehicles Using EMB System
Authors: Li Jian , Ma Chi , Jiang Yuqiang 
Published: March 2024

It is urgent for automated electric transportation vehicles in coal mines to have the ability of self-adaptive tracking target constant deceleration to ensure stable and safe braking effects in long underground roadways. However, the current braking control system of underground electric trackless rubber-tired vehicles (UETRVs) still adopts multi-level constant braking torque control, which cannot achieve target deceleration closed-loop control. To overcome the disadvantages of lower safety and comfort, and the non-precise stopping distance, this article describes the architecture and working principle of constant deceleration braking systems with an electro-mechanical braking actuator. Then, a deceleration closed-loop control algorithm based on fuzzy neural network PID is proposed and simulated in Matlab/Simulink. Finally, an actual brake control unit (BCU) is built and tested in a real industrial field setting. The test illustrates the feasibility of this constant deceleration control algorithm, which can achieve constant decelerations within a very short time and maintain a constant value of −2.5 m/s2 within a deviation of ±0.1 m/s2, compared with the deviation of 0.11 m/s2 of fuzzy PID and the deviation of 0.13 m/s2 of classic PID. This BCU can provide electric and automated mine vehicles with active and smooth deceleration performance, which improves the level of electrification and automation for mine transport machinery.
ASUHAN KEBIDANAN KOMPREHENSIF PADA NY.E DI PUSKESMAS MALANGBONG KABUPATEN GARUT
Authors: Regina Putri Natasha , Noviani Fadilah Lola 
Published: March 2024

Proses kehamilan, persalinan, nifas, dan kelahiran BBL merupakan siklus fisiologis yang dialami oleh seorang perempuan. Meskipun hal tersebut adalah hal yang fisiologis, tetap akan mengalami perubahan fisik maupun psikologis yang akan menimbulkan ketidaknyamanan utamanya pada ibu hamil trimester 3. Peran bidan sangatlah dibutuhkan untuk mendampingi perempuan dalam mengatasi ketidaknyamanan tersebut. Penerapan asuhan secara berkesinambungan (continuity of care) penting dilakukan oleh bidan karena memberikan dampak positif bagi perempuan dan memberikan outcome yang baik, sebab continuity of care dapat memudahkan bidan dalam melakukan deteksi dini komplikasi.
Penelitian ini menggunakan metode studi kasus dengan teknik pengumpulan data primer dan sekunder yang dilakukan sejak Bulan Januari - Mei 2023 di Puskesmas Malangbong Kabupaten Garut. Asuhan diberikan sejak usia kehamilan ibu 39 Minggu hingga masa nifas KF4, serta asuhan pada neonatus hingga KN3.
Hasil penelitian didapatkan bahwa pada asuhan kehamilan didapatkan ketidaknyamanan berupa sering buang air kecil. Proses persalinan berlangsung secara normal dan ibu datang saat fase persalinan telah memasuki kala II. Tidak terdapat permasalahan selama masa nifas, produksi ASI sangat banyak. Dilakukan perawatan payudara, senam nifas dan konseling KB. Asuhan pada BBL berjalan lancar, tidak terdapat masalah apapun pada bayi. Bayi telah mendapatkan imunisasi HB0. Imunisasi BCG serta polio 1 akan diberikan saat usianya genap satu bulan. Dilakukan pijat bayi saat KN 3.
Asuhan yang dilakukan telah sesuai dengan manajemen kebidanan. Diharapkan bidan dapat melakukan penerapan continuity of care secara komprehensif sesuai kebutuhan pasien dan sesuai kewenangan profesi bidan yang telah ditetapkan.
Influence of Celebrity Endorser and Product Quality on Purchase Decision Through Brand Image Package PT Aminareka Perdana
Authors: Dhamayanty Stanny , Nokialita Fitri 
Published: March 2024

This research aims to look at the direct and indirect effects of celebrity endorser, product quality, and brand image on purchasing decisions. The group studied was PT Arminareka Perdana Umrah pilgrims. Samples were taken from 100 respondents randomly. Data collection was carried out by conducting a survey of consumers of Umrah pilgrims. The variables studied were celebrity endorser (X1), product quality (X2), product image (Y), and purchase decision (Z). The data obtained were then analyzed using descriptive methods and path analysis. After the research was carried out, the results obtained were that the variable celebrity endorser (X1) and product quality (X2) had a direct effect on purchasing decisions (Z). Meanwhile, the relationship between celebrity endorser (X1) and product quality (X2) can indirectly affect purchasing decisions. The results of the path analysis test show that the research variable celebrity endorser (X1) influences purchasing decisions through brand image and product quality (X2).