bluuebunny/crossref_metadata_2025_split huggingface dataset:
La perception du numérique en pédagogie universitaire aujourd’hui, entre transformations et permanences : résultats d’une enquête à l’Université de Strasbourg
Authors: Kennel Sophie , Guillon Stéphane , Mailles-Viard Metz Stéphanie 
Published: March 2024

À partir d’une étude menée auprès des enseignants et enseignants-chercheurs de l’Université de Strasbourg en France, nous analysons le ressenti des 418 répondants à une enquête portant sur leur expérience d’enseignement durant les deux périodes d’enseignement en ligne contraint de 2020 et 2021, liées à la pandémie. Nos résultats montrent, sans surprise, un ressenti négatif de la part des personnes interrogées : 79 % des répondants considèrent que l’expérience d’enseignement vécue depuis mars 2020 a été difficile ou très difficile et 51 % en tirent un bilan négatif. La comparaison des réponses entre les personnes ayant exprimé un ressenti négatif et celles s’estimant plutôt satisfaites de l’expérience pointe des écarts significatifs portant sur la maîtrise des outils et la résolution de problèmes techniques ou matériels, sur l’enseignement et la production de ressources pédagogiques, sur la qualité des interactions avec l’étudiant, ainsi que sur l’adaptation des pratiques pédagogiques à l’enseignement à distance, dans un contexte de contraintes temporelles. Nous constatons cependant que ce n’est pas tant la compétence ou la pratique numérique qui singularisent les acteurs que leur perception de la relation à l’étudiant et des pratiques et des compétences pédagogiques.
Patient registry data on the efficacy and tolerability of adalimumab biosimilar in ankylosing spondylitis: A retrospective multicenter observational study
Authors: Awadh Nabaa Ihsan , Gorial Faiq I. , Humadi Yasameen Abbas , Ridha Asal Adnan , Jassim Nizar Abdulateef , Munshed Mohammed Hadi , Maroof Avin , Alqazzaz Ali , Qaradaghi Taha Ahmed , Younis Ali Abdulrahman , Moayad Marwa , Mahmood Chiman Hasan , Ibrahim Mariam Khalil , Hammadi Reem Abbas 
Published: March 2024

Abstract:

BACKGROUND:
Adalimumab, a tumor necrosis factor-α inhibitor, is an approved treatment for ankylosing spondylitis (AS). In Iraq, a biosimilar of adalimumab (ABP 501; Amgevita®) has been licensed for prescription since 2021. However, there have been no previous studies on its efficacy and safety in Iraqi AS patients. Multiple studies have shown that adalimumab biosimilars are effective and well tolerated, with comparable rates of clinical response, adverse events (AEs), and immunogenicity to the reference product.

OBJECTIVES:
To evaluate the efficacy and safety of Amgevita in Iraqi patients with AS.

PATIENTS AND METHODS:
A retrospective multi-center observational study involving 72 patients with active AS for whom Amgevita 40 mg was prescribed every 2 weeks The data were collected from Amgevita registry data across multiple centers in Iraq. Patients’ entire data sets were retrieved and examined for disease activity parameters and recorded adverse reactions up to 12 months of Amgevita medication.

RESULTS:
The cumulative percentage of response in active AS patients treated with Amgevita was 82% after 3 months (the baseline) and 61% after 12 months. The mean change from the baseline in the Bath AS Disease Activity Index was statistically significant (−0.5 [P = 0.033; 95% confidence interval (CI): −0.87 to −0.04] and −1.14 [P = 0.0001; 95% CI: −1.68 to −0.60]) at 3 months and 12 months, respectively. On multivariate Cox regression modeling, disease activity was a predictor of a decreased response to treatment by 49%. There were no new, significant AEs.

CONCLUSIONS:
Adalimumab biosimilar (ABP501; Amgevita®) is clinically effective and tolerable over 12 months of follow-up in Iraqi patients with AS.
An interesting case of ocular flutter, myoclonus, and ataxia in the postpartum period
Authors: Gotur Amrita J , Saluja Alvee , Anees Shahbaz , Verma Jyoti , Sinha Prerna 
Published: March 2024

Abstract
Opsoclonus–myoclonus–ataxia syndrome is a well-established neurologic syndrome with paraneoplastic, postinfectious, immune-mediated, or idiopathic etiology. Ocular flutter and opsoclonus are in the same continuum with a common pathophysiology; however, their phenomenology is distinct. While eye movements in ocular flutter are strictly confined to the horizontal plane, those in opsoclonus are multidirectional. There are few case reports describing the combination of ocular flutter, myoclonus, and ataxia. In this case report, we describe a woman with the abovementioned features in the postpartum period with dramatic response to immunotherapy.
Sunglasses as an alternative alleviating agent for secondary Meige’s syndrome: Electrophysiological evidence
Authors: Prasad Shweta , Holla Vikram V , Pal Pramod K 
Published: March 2024

Abstract
Blepharospasm may be the most disabling of symptoms in Meige’s syndrome, and sunglasses or specialized tinted lenses (FL-41) have been suggested to be useful. The present report provides electrophysiological evidence to substantiate the utility of sunglasses as an alternative alleviating agent for Meige’s syndrome secondary to deep cerebral venous thrombosis with improvement extending beyond blepharospasm.
Palmaris brevis spasm syndrome: The treatable hypothenar dimpling
Authors: Ganguly Jacky , Pandita Neha , Banerjee Shubhrangshu , Mukherjee Soumava , Singh Nilam , Basu Purba , Kumar Hrishikesh 
Published: March 2024

Abstract
Palmaris brevis spasm syndrome is a rare disorder, mostly reported with occupational overuse of a computer keyboard, mouse, pipette, and vibratory tools or after the use of arm braces. Rarely, it can be spontaneous. It is clinically characterized by spontaneous contraction of the palmaris brevis muscle over the hypothenar eminence. Here, we report a patient with long-standing, spontaneous, and bilateral palmaris brevis spasm syndrome without any occupational exposure who demonstrated excellent response to botulinum toxin therapy. Clinicians should be aware of this rare but treatable entity in patients presenting with hypothenar spasms.
Pramipexole-induced syndrome of inappropriate antidiuretic hormone secretion in a patient with young-onset Parkinson’s disease
Authors: Panigrahi Baikuntha , Radhakrishnan Divya M , Rajan Roopa , Agarwal Ayush , Pandit Awadh Kishor , Srivastava Achal K 
Published: March 2024

Abstract
Pramipexole, a dopaminergic agonist, has rarely been implicated as a cause of hyponatremia in patients with Parkinson’s disease (PD). Pramipexole-induced stimulation of anti-diuretic hormone results in euvolemic hyponatremia. This is often neglected, and hyponatremia may lead to worsening of the motor symptoms with PD and an unnecessary increase in dopaminergic medications, causing disabling dyskinesias. This case report describes a patient with young-onset PD who developed new-onset hyponatremia due to pramipexole-induced syndrome of inappropriate anti-diuretic hormone within 3 months of starting the drug.
Pattern of failure after adjuvant radiation therapy in oral cavity cancer patients: Data from tertiary care institute in North India
Authors: Sidhu Manjinder Singh , Jain Sumeet , Brar Gurpreet , Dhall Kunal , Sood Sandhya , Aggarwal Ritu , Jain Kunal , Singh Jagdeep , Garg Nitish , Bhutani Puneet , Paul Davinder , Beriwal Sushil 
Published: March 2024

Abstract

Objectives:
To review failure patterns in oral cavity squamous cell carcinoma treated with surgery and adjuvant radiation therapy.

Materials and Methods:
All patients with biopsy-proven stage I-IVB oral cavity squamous cell carcinoma (OCSCC) treated with surgery and adjuvant therapy between 2018 and 2022 were evaluated. Outcome measures were 3-years loco-regional recurrence (LRR), overall survival (OS), and progression free survival (PFS). LRR was spatially localized in relation to contour and dose distribution.

Results:
A total of 85 patients treated between years 2018 to 2022 were evaluated with median follow-up of 19 months. Disease subsites were oral tongue (37.6%) and bucco-alveolar complex (62.4%). Of a total of 25.9% failures, 16/85 (18.8%) were local, 9/85 (10.6%) were regional, 18/85 (21.2%) were locoregional, and 10/85 (11.8%) were distant. For LRR, total in-field failure was 11.8%, marginal failure was 4.7%, and out-of-field failure was seen in 2.4% cases. The 3-year actuarial local, regional control, and LRR in our study were 69%, 84%, and 67%, respectively. The cumulative rates of OS were 72% and PFS was 56%. On univariate analysis, independent factors for local failure were perineural invasion (PNI) (OR = 5.89, P = 0.03), lymph vascular space invasion (LVI) (OR = 3.69, P = 0.05), and pathological N3 (OR = 3.69, P = 0.02). For regional, failure was PNI (OR = 4.53, P = 0.038). For locoregional, failure was PNI (OR = 6.13, P = 0.002) and for distant, failure were PNI (OR = 5.80, P = 0.013), pathological N3 (OR = 4.35, P = 0.03) and LVI (OR = 4.66, P = 0.03). On multivariate Cox proportional hazard analysis, for local, failure risk factors were PNI (HR = 4.32, P = 0.01) and pathological N3 (HR = 3.27, P = 0.047), for locoregional, failure was PNI (HR = 4.42, P = 0.006), and for distant, failure was PNI(HR0 = 4.29, P = 0.05).

Conclusions:
In our cohort of patients, the most common failure was in-field LRR. PNI was significantly associated with local, locoregional, and distant failure on Cox analysis. In addition to PNI, pathological N3 was the cause of local failure.
Area to “Watch Out” for Dental Caries in Schoolchildren of Age 3–12 Years Based on Dental Health Diet Score – A Cross-sectional Study
Authors: Lokesh S , Krishnakumar R. , Rajakumari S. , Catherine N. C. , Divyapriya G. K. , Malarkodi N. 
Published: March 2024

Abstract

Aim:
The aim of the study was to determine the prevalence of dental caries among children of age 3–12 years based on the dental health diet score (DHDS).

Settings and Design:
Dental caries in children is evaluated using food score, nutrient score, and sweet score.

Materials and Methods:
A total of 2288 children were screened/examined, for the presence of dental caries using dmft/DMFT index, by randomly selecting 10 schools within a radius of 5 km. Informed written parental consent was obtained. A closed-ended questionnaire which included a diet chart was given 2 days before the examination. All children aged 3–12 years were included in the study. DHDS was calculated and compared with standard chart. All data obtained were tabulated and statistically analyzed using SPSS version 16 (IBM Corp.), with the P < 0.05 value considered statistically significant.

Results:
Dental health diet score values obtained from the present study shows that, 71.8% children were in badly need of diet counselling and diet modification, 13.7% of children were need to be educated and 15.5% of children were just need to be motivated. On comparing the DHDS score with the dental caries, the mean dmft/DMFT score of “not adequate and barely adequate” categories was 2.3 ± 1.8 and 2.4 ± 2.1, respectively. Their values were found to be statistically significant.

Conclusion:
Area to “Watch-out” for dental caries in children – Malnutrition. Equal emphasis is needed in both avoidance of sugary foods and maintenance of proper nutrition in children.
Role of Multidetector Computed Tomography in the Assessment of Malignant Large-Bowel Lesions
Authors: Gafoor Hameed Fazal , Krishna Abhay 
Published: March 2024

Abstract

Background and Objective:
Intestinal disease can be examined with computed tomography (CT), which also allows for an assessment of extraintestinal pathology. In addition, CT enhances diagnostic specificity (SP) and offers an exceptional evaluation of the perienteric anomalies that typically accompany bowel disorders. The preoperative grading accuracy was found unappealing, varying between 48% and 77%. The bowel wall thickening among individuals with colorectal cancer is classified as benign or malignant depending on the extent of thickening, symmetrical and asymmetrical thickening, focal, segmental, or diffuse involvement, and related perienteric anomalies. The current study used a cohort of patients with colorectal cancers. The study aimed to find out sensitivity (SN) and SP of multidetector CT (MDCT) in detecting malignant pathologies of the large bowel by comparing the MDCT diagnosis with findings of histopathological examination.

Materials and Methods:
The study was an observational study, done from December 2019 to December 2021 in the Department of Radiodiagnosis, MES Medical College, Perinthalmanna, Kerala. The patients included were clinically and radiologically indicative of bowel lesions, who were referred with clinical suspicion of large-bowel diseases. The 16-slice Philips ACCESS MDCT scanner was used for MDCT. Oral, rectal, and IV contrast were used after plain CT imaging.

Results:
The study consisted of 63 patients, of which 53 lesions were found to be malignant on MDCT. However, only 51 patients had cancer verified by histology. Histopathology indicated that the two instances, which the MDCT had identified as malignant, were actually inflammatory. Therefore, for the diagnosis of malignant tumors, MDCT had a SN of 98.10%, SP of 81.80%, a positive predictive value of 96.20%, and a negative predictive value of 90.00% in the present study. On histology, a case that was first identified as benign on MDCT turned out to be malignant. Benign abnormalities on CT showed broad intestinal involvement and modest, symmetric wall thickening. The CT characteristics of malignant tumors included localized intestinal involvement and pronounced asymmetric wall thickening.

Conclusion:
MDCT has shown to be a trustworthy method for the purpose of evaluating and discriminating benign from malignant colon and rectum tumors. In addition to merely identifying a tumor, MDCT also offers additional information on any perienteric anomalies that may be present around the lesion, the presence of lymph node enlargement, invasion of adjacent viscera, the existence of intestinal obstruction, and metastatic tumors.
WhatsApp Support Group for 950 Children and Adolescents/Parents with Type 1 Diabetes – Physician’s Perspective on Merits and Demerits
Authors: Kesavadev Jothydev , Shankar Arun , Krishnan Gopika , Sanal Geethu , Sreelakshmi R. , Jothydev Sunitha 
Published: March 2024

Abstract
Even though the concept of telemedicine (TM) is more than a century old, we have probably never harnessed the multitude of benefits offered by this technology. With the outbreak of the COVID-19 pandemic, TM became legal and its practice in hospitals has opened up new avenues for effective and timely delivery of treatment, especially for diabetes. Evidence-based research has found TM-based management of type 1 diabetes (T1D) efficient in delivering equivalent or better care and outcomes when compared to only face-to-face visits. A T1D community consisting of parents and children with T1D was formed in Kerala in 2017. Almost all of these parents had access to WhatsApp and were part of the T1D community on WhatsApp. Here, we review the merits and demerits of utilizing the WhatsApp support group in assisting people with T1D to better manage diabetes and improve their quality of life.
Prevalence of Complementary and Alternate Medicine Use among People with Diabetes in Kerala, India
Authors: Kesavadev Jothydev , Saboo Banshi , Shankar Arun , Krishnan Gopika , Jothydev Sunitha , Chandran Vysakh , Basanth Anjana , Raj Sourav , Manojan K K , Aravind S R 
Published: March 2024

Abstract

Introduction:
The use of complementary and alternative medicine (CAM) among individuals with diabetes has seen a significant surge. Estimates show that 80% of people in developing countries still prefer CAM for the treatment of health conditions. CAM encompasses various medical practices outside mainstream medicine and is increasingly employed for the reasons such as enhancing control over treatment, adopting a holistic health approach, and managing conditions alongside conventional medicine. CAM is widely embraced, due to cultural factors and perceived benefits, driving its popularity. Despite varying opinions on the impact of CAM on glycemic control, its substantial use prompts the need for a focused study.

Objective:
The present study explores the utilization of CAM in people with diabetes and examines potential associations with various factors that could influence CAM use.

Methods:
Between October 2022 and June 2023, a cross-sectional survey was conducted among 335 people with type 2 diabetes at our center using a validated structured questionnaire to explore their utilization of CAM.

Results:
Among the study participants, 40.7% used CAM to treat diabetes. Among them, 40.6% of subjects used CAM as complementary to modern medicine and 59.4% used CAM as an alternative to modern medicine. 65.2% of people used Ayurveda, followed by homeopathic medicines (16.3%), yoga (5.2%), naturopathy (3%), massage therapy (1.5%), and ladoo therapy (0.7%). Some of the participants had used multiple types of CAM for their diabetes treatment. 1.5% of participants used homeopathy and Ayurveda decoction. 0.7% of CAM users used Ayurveda + naturopathy, a combination of Ayurveda + Unani, and the combination of Ayurveda + protein supplements. Other therapies (traditional medicine) were found to be used by 1.5% of CAM users. Among the CAM users, 73.5% chose CAM for the treatment of diabetes, while for 14.4%, it was recommended by family and friends. It was found that 83.7% of subjects discontinued CAM use, while a minuscule share of 16.3% continued with CAM. Among those discontinued, 43.4% did not find CAM to be effective, whereas 44.3% had other reasons for discontinuing CAM.

Conclusion:
These findings highlight the need for increased awareness and education regarding CAM use and its potential hazards. Health-care providers should consider discussing CAM use with their patients and encourage them to report its use to ensure comprehensive and safe medical care. Proper CAM practice and management are important for people with diabetes.
Association of serum periostin levels with asthma control status and severity in children
Authors: Moustafa Asmaa N. , Kasem Ahmed H. , Yousef Ebthal Essam , Moness Hend M. , Fadle Yossra Samir 
Published: March 2024

Objectives
Periostin is a promising indicator in the pathogenesis of T-helper type-2 allergic reactions. This study aimed to identify the relationship between serum periostin levels and asthma control in children.

Procedure
In this study, 90 children were recruited and grouped as follows: 30 children in a control group (group I), and another group comprising 60 children with physician-diagnosed asthma (group II). The control status and severity of asthma in patients were assessed in accordance with the recent Global Initiative for Asthma guidelines. Serum periostin concentrations were examined in all enrolled patients using an enzyme-linked immunosorbent assay kit.

Results
The median (interquartile range) periostin levels of asthmatic children were substantially higher than those of healthy children [23 (13.1, 48) vs. 15 (10.5, 24); P = 0.015]. Based on a simple logistic regression analysis, serum periostin concentrations strongly correlated with asthma (odds ratio = 1.037; confidence interval = 1.008–1.066; P = 0.012). In a receiver operator characteristic curve analysis, the area under the curve for serum periostin was 0.984, with 100% sensitivity and 95.35% specificity in detecting uncontrolled asthma.

Conclusion
Serum periostin levels were shown to be a helpful biomarker for assessing childhood asthma control in children.
Longitudinal assessment of growth and neurodevelopment of children with in utero severe acute respiratory syndrome coronavirus 2 exposure: A prospective cohort study
Authors: Mukhopadhyay Sujaya , Sharma Ritu , Gupta Rakesh , Yadav Sanju , Qamal Sahabzada Faisal , Imran Shazmeen 
Published: March 2024

Introduction
Research related to the impact of maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on fetuses and neonates remains limited. The majority of previous studies have focused on immediate outcomes. We conducted this prospective cohort study to evaluate the effect of in utero SARS-CoV-2 exposure on the growth and neurodevelopment of infants, considering the scarcity of long-term follow-up studies in the literature.

Primary Objective
The primary objective of the study was to compare neurodevelopment and growth up to the age of 1 year among coronavirus disease COVID-positive and COVID-negative neonates born to COVID-positive mothers.

Secondary Objectives
The secondary objectives of the study were to assess the status of exclusive breastfeeding in infants at the age of 6 months and to assess the risks of vertical and horizontal transmission of COVID-19 infection.

Methods
We included live neonates with gestational age >28 weeks born to pregnant women who tested positive for COVID-19 by reverse transcription polymerase chain reaction and delivered at the institute in this prospective observational cohort study. Details related to delivery and neonatal profile, including the neonatal COVID status were collected. Neonates were followed up at 6 months and 1 year for physical growth profile and neurodevelopmental profile using World Health Organization growth charts and the Baroda Development screening test (BDST).

Results
A total of 6 SARS-CoV-2-positive and 82 SARS-CoV-2-negative neonates were followed until the age of 1 year. There was no statistically significant difference between the SARS-CoV-2-positive and SARS-CoV-2-negative cohorts concerning gestational age (P-value 0.300), birth weight (P-value 0.988), and neonatal intensive care unit admission (P-value 0.288). Approximately 65.9 and 45.4% of infants were still exclusively breastfeeding at the ages of 6 months and 1 year, respectively. No difference was observed in wasting (P-value 0.393) and stunting at the ages of 6 months (P-value 0.656) and 1 year between the two cohorts. Furthermore, no significant difference was observed in neurodevelopmental status at 6 months (P value for BDST score 0.236; P value for developmental quotient (DQ) 0.446) and 1 year (P value for BDST score 0.635; P value for DQ 0.666) between the two groups.

Conclusion
Our study generated evidence that in utero exposure to SARS-CoV-2 infection does not seem to affect the growth and neurodevelopment of neonates born to SARS-CoV-2-positive mothers; however, further studies including nonexposed controls, are warranted to support our findings. Furthermore, the benefits of rooming-in and breastfeeding on the neurodevelopment and physical growth of infants far outweigh the minimal risk of horizontal transmission.