bluuebunny/crossref_metadata_2025_split huggingface dataset:
SLOWDOWN OF REPLICATIVE AGING OF FIBROBLASTS BY HYALURONAN COMPLEXES WITH GOLD NANOPARTICLES
Authors: Хабаров В.Н. , Бойков П.Я. , Дробинцева А.О. , Миронова Е.С. , Зубарева Т.С. , Кветной И.М. , Пальцев М.А. 
Published: March 2024

В исследовании определена активность генов сиртуина-1, гиалуронидазы, цитокина TGF-β, кальретикулина в процессе репликативного старения фибробластов человека in vitro и влияние препаратов гиалуронана с наночастицами золота на активность репликативного старения клеток. Сравнивали экспрессию белков исследуемых генов с помощью специфичных маркеров на 7-м и 14-м пассажах культивирования фибробластов, выделенных из кожи человека, без препаратов и при наличии препаратов в ростовой среде. В настоящей работе показано снижение активности гена сиртуина-1 и повышение экспрессии гиалуронидазы в процессе репликативного старения фибробластов человека. Найдено средство замедления репликативного старения путем активации гена SIRT1 и снижения активности гиалуронидазы введением в ростовую среду препаратов гиалуронана с наночастицами золота. Обсуждаются возможные переходы клеток в патологическое состояние, вызываемые репликативным старением, и механизмы замедления репликативного старения фибробластов человека.
Determination the activity of the genes of sirtuin-1, hyaluronidase, TGF-β cytokine, calreticulin in the process of replicative aging of human fibroblasts in vitro and the effect of hyaluronan preparations with gold nanoparticles on the activity of replicative cell aging. Compared the expression of proteins of the studied genes using specific markers at 7 and 14 passages of cultivation of fibroblasts isolated from human skin, without drugs and in the presence of drugs in the growth medium. This work shows a decrease in the activity of the sirtuin 1 gene and an increase in the expression of hyaluronidase in the process of replicative aging of human fibroblasts. Found a means of slowing down replicative aging by activating the SIRT-1 gene and reducing the activity of hyaluronidase in action in the growth medium of hyaluronan preparations with gold nanoparticles. The discussed variants of cell transitions to the pathological state, caused by replicative aging and the mechanisms of slowing down the replicative aging of human fibroblasts.
COVID-19 AS A TRIGGER FOR THE ONSET AND PROGRESSION OF NEURODEGENERATIVE PATHOLOGY PREDOMINANTLY IN ELDERLY AND SENILE POPULATION
Authors: Арьев А.Л. , Лаптева Е.С. 
Published: March 2024

Представлен краткий обзор литературы о связи перенесенного COVID-19 и появления или прогрессирования нейродегенеративной патологии. Показаны этиопатогенетические механизмы поражения ЦНС. Проанализирована доказательная база влияния SARS-CoV-2 на ЦНС, что приводит к развитию долгосрочных неврологических заболеваний, включая нейродегенерацию. Сделан вывод о необходимости разработки официальных критериев и методических рекомендаций по мониторированию в особенности пациентов пожилого и старческого возраста на предмет возможного начала или прогрессирования нейродегенеративной патологии.
A brief literature review on the association of COVID-19 and the manifestation or progression of neurodegenerative pathology is presented. The etiopathogenetic mechanisms of central nervous system damage are shown. The evidence base of the effect of SARS-CoV-2 on the central nervous system, which leads to the development of long-term neurological diseases, including neurodegeneration, is analyzed. It is concluded that it is necessary to develop official criteria and methodological recommendations for monitoring especially elderly and senile patients for possible onset or progression of neurodegenerative pathology.
DYNAMICS OF MORBIDITY IN THE ELDERLY ACCORDING TO THE CLASS OF EYE AND ITS APPENDAGE DISEASES IN THE ARKHANGELSK REGION
Authors: Трофимова А.А. , Санников А.Л. , Ясько Н.Н. 
Published: March 2024

В статье описаны тенденции первичной заболеваемости пожилых по классу болезней глаза и его придаточного аппарата (H00–H59) в Архангельской обл. в 2017–2021 гг. Проанализированы особенности заболеваемости по полу, возрасту, форме оказания медицинской помощи, нозологическим формам по данным Территориального фонда обязательного медицинского страхования Архангельской обл. (ТФОМС АО), n=418 196. Показатели первичной заболеваемости болезнями глаза у пожилых имеют общий отрицательный тренд, усиливающийся в 2020 г. во время пандемии COVID-19. У мужчин динамика заболеваемости за 5 лет ниже, чем у женщин. Первичная заболеваемость выше в группе 70–79 лет, чем в других возрастных группах, в относительных и абсолютных значениях. 90 % первичных диагнозов выставлено при амбулаторном приеме, 6 % — в условиях круглосуточного стационара. Среди нозологических форм лидирующими являются болезни хрусталика (H25–H28) — 41,9 % и глаукома (H40–H42) — 20,6 %. Полученные данные могут быть использованы для организации профилактических мер, например составления плана диспансеризации и диспансерного наблюдения пожилого населения, а также для оценки сенсорных дефицитов при анализе уровня самообслуживания у пожилых при комплексной гериатрической оценке.
The article describes the trends in the primary morbidity of the elderly by the class of eye dis[1]ease and its accessory apparatus (H00–H59) in the Arkhangelsk region of Russian Federation from 2018 to 2021, analyzes the features of morbidity by gender, age, form of medical care, nosology according to the Territorial Fund of Compulsory Medical Insurance of the Arkhangelsk region (TFOMS AR), n=418 196. The indicators of primary morbidity of eye diseases in the elderly have a general negative trend, increasing in 2019 during the COVID-19 pandemic. In men, the dynamics of morbidity over five years is lower than in women. Primary morbidity is higher in the group of 70–79 years than in other age groups in relative and absolute values. 90 % of primary diagnoses were made during outpatient admission, 6 % in a round-the-clock hospital. Among nosologies, the leading ones are lens diseases (H25–H28) — 41,9 % and glaucoma (H40–H42) — 20,6 %. The data obtained can be used to organize preventive measures, for example, drawing up a plan for medical examination and dispensary observation of the elderly population, as well as to assess sensory deficits when analyzing the level of functionality in the elderly with a comprehensive geriatric assessment.
PERIODONTAL STATUS AND POSSIBILITIES OF ITS OPTIMIZATION IN ELDERLY PATIENTS
Authors: Солдатова Л.Н. , Иорданишвили А.К. , Ермолаева Л.А. 
Published: March 2024

Исследование заключается в изучении состояния гигиены рта и тканей пародонта у пациентов пожилого возраста в процессе динамического наблюдения в течение 12 мес. Под наблюдением находились пациенты 61–74 лет с воспалительными заболеваниями пародонта, частичным отсутствием естественных зубов на обеих челюстях. Исследование показало существенное улучшение гигиены рта и состояния тканей пародонта у лиц пожилого возраста при использовании лечебно-профилактических средств отечественного производства для индивидуальной интраоральной гигиены и профессиональной гигиены рта не менее 4 раз в год.
The study consists in studying the state of oral hygiene and periodontal tissues in elderly patients during dynamic follow-up for 12 months. Patients aged 61–74 years with inflammatory periodontal diseases and partial absence of natural teeth in both jaws were under observation. The study showed a significant improvement in oral hygiene and the condition of periodontal tissues in the elderly when using therapeutic and prophylactic products of domestic production for individual intraoral hygiene and professional oral hygiene at least four times a year.
Assessment of the Nutritional Status and Skeletal Muscle Condition in Patients With Resectable Gastric Cancer
Authors: Uvarov I. B. , Asipovich O. M. , Derbenev S. N. , Yashchenko A. V. , Andreev D. V. , Porhanov V. A. , Manuilov A. M. 
Published: March 2024

Background: Patients with gastric cancer (GC) are at high risk of nutrient deficiencies (ND) that can negatively affect the postoperative period and long-term treatment outcomes.Objective: To assess the nutritional status (NS) and skeletal muscle condition in patients with resectable stage I-III GC.Materials and methods: Our study included 102 GC patients: 64 men (62.7%) and 38 women (37.3%) aged 31 to 77 years. During the assessment we used the NRS-2002 system, determined laboratory markers of the NS, calculated the Nutritional Risk Index (NRI), and evaluated the condition of adipose tissue and skeletal muscles using computed tomography.Results: We found that 70.6% of the patients had ND: NRS-2002 score < 3 points (52%) and NRS-2002 score ≥ 3 points (18.6%). Risk factors for ND were tumor localization in the cardia and stage III GC. Laboratory markers of ND were transferrin and NRI. Among the examined patients (n = 80) sarcopenia was detected in 10 (12.5%) patients: 1 patient (1/25; 4.0%) from the group without ND, 6 patients (6/42; 14.3%) from the group with NRS-2002 score < 3 points, and 3 patients (3/13; 23.1%) from the group with NRS2002 score ≥ 3 points, (P = .212). In multivariate logistic regression analysis, independent factors associated with sarcopenia were age, body mass index, and total protein.Conclusions: All GC patients selected for radical surgery should undergo nutritional assessment using special tools (NRS-2002, NRI) and evaluation of the skeletal muscle condition. Sarcopenia may occur in patients with no clinical or laboratory evidence of ND. In GC patients at nutritional risk, preand postoperative nutritional support should be considered to reduce the ND-related risks.
Computed Tomography of Cerebral Contusions in Children Younger Than 3 Years
Authors: Zaytseva E. S. , Akhadov T. A. , Mamatkulov A. D. , Bozhko O. V. , Ublinskiy M. V. , Melnikov I. A. , Khusainova D. N. 
Published: March 2024

Background: Cerebral contusions occur in approximately 43% of blunt head trauma cases. The gyri are predominantly affected, although severe traumatic brain injury (TBI) may damage the subcortical white matter and deep structures within the brain. Computed tomography (CT) of the brain is used to evaluate all forms of intracranial injuries, fractures, cerebral edema, and other associated injuries.Objective: To analyze the CT potential in the diagnosis of cerebral contusions during the acute phase of TBI in children younger than 3 years.Materials and methods: In 2021-2022 we performed CT using a Philips Ingenuity Elite 128 slice CT scanner in 1334 children with TBI (730 boys and 604 girls younger than 3 years). The area of interest in the examined children was the skull and cervical spine. We did not use enhancement. The effective dose range varied from 1.27 to 1.91 mSv.Results: Of 510 children, 448 (87.84%) patients had skull fractures that combined with intracranial injuries in 366 (81.7%) children, with 262 (71.58%) of them having severe injuries (Glasgow Coma Scale ≤ 8) and 36 (9.83%) of them undergoing surgery. Cerebral contusions were diagnosed in 58.5% (214 of 366) of children. Contusions (98% of which were hemorrhagic) had different volumes and degrees of hemorrhage and edema. The foci of contusions were in the frontal (37.1%), temporal (34.3%), parietal (20.6%), and, less often, occipital (8%) lobes.Conclusions: CT is the preferred imaging modality in acute TBI, which enables to accurately detect and adequately treat cerebral contusions, preventing secondary injuries. CT is the main diagnostic tool and should be performed in all children with TBI within the first hours after injury.
OPTIMIZING ISLAMIC BANK PERFORMANCE FOR UNLOCKING PATH OF PROFITABILITY
Authors: Mkiyes Hussein 
Published: March 2024

This study investigated the impact of some investment fund ratios in Islamic banks operating in Syria, represented by both the financing-to-deposits ratio FDR and the resource investment ratio IRR, in addition to the liquidity ratio, on the profitability of these banks, represented by ROA and ROE. In addition, this study aimed to identify the reality of the financial performance of Syrian Islamic banks according to these indicators and clarify the extent to which there are significant differences between them. This was done during the period from 2010 to 2022, based on the annual financial statements published in the annual financial reports issued by the banks under study.
The study found that there were significant differences in the performance of the Syrian Islamic banks studied regarding indicators of fund investment. While the performance of these banks was similar in terms of indicators of profitability and liquidity, there were no significant differences between any of them. The study also concluded that there is a positive and significant effect of FDR and IRR on ROE overall, compared to the absence of any significant effect of these two indicators on ROA. There is no significant effect of the liquidity ratio on ROA or ROE overall.
PENGARUH TEHNIK FOKUS LIMA JARI TERHADAP MASYARAKAT YANG MENGALAMI KECEMASAN SELAMA MASA PANDEMI COVID-19
Authors: Dwi Novial Fitri Linda 
Published: March 2024

Latar Belakang: Pandemi COVID-19 memberikan dampak yang sangat luas terhadap seluruh tatanan kehidupan masyarakat. Dampak negatif yang dirasakan oleh masyarakat dari bencana ini pun mengarah kepada perubahan kondisi kesehatan baik fisik maupun mental. Salah satu masalah perubahan kesehatan mental yang dialami oleh masyarakat selama masa pandemi yaitu kecemasan. Masyarakat cemas saat harus berada di rumah saja, mereka takut saat beraktivitas apalagi harus menjalani isolasi mandiri di rumah. Hal ini memberikan pengaruh negatif terhadap kondisi kualitas kesehatan mental masyarakat. Perasaan cemas perlu dikelola secara tepat agar mampu meningkatkan ketahanan fisik seseorang. Salah satu cara yang dapat dilakukan yaitu dengan tehnik fokus lima jari. Tehnik ini bertujuan untuk menurunkan kecemasan sehingga memberi pengaruh relaksasi bagi seseorang. Tujuan: Penelitian ini bertujuan untuk mengalisis pengaruh tehnik fokus lima jari terhadap kecemasan yang dialami oleh masyarakat selama masa pandemi COVID-19. Metode: Metode yang dipergunakan yaitu mixed method dengan desain eksplanatori. One group pre dan post-test desain untuk mengetahui pengaruh tehnik fokus lima jari terhadap kecemasan kemudian dilanjutkan dengan wawancara mendalam untuk mengetahui fenomena yang dialami oleh para responden. Sampel sebanyak 42 orang dengan tehnik accidental sampling dan dilanjutkan dengan wawancawa kepada 10 partisipan dengan kriteria inklusi usia diatas 15 tahun dan melakukan konsultasi melalui media online. Instrumen yang dipergunakan untuk mengukur kecemasan yaitu HARS. Hasil: Penelitian dilakukan secara daring dalam kurun waktu 1 tahun ( September 2020-September 2021). Hasil t test menunjukkan p value (0.000 > 0.05) dengan beda mean sebesar (36.500 – 32.500) artinya ada pengaruh tehnik fokus lima jari terhadap penurunan kecemasan masyarakat selama masa pandemi COVID-19. Hasil wawancara diperoleh empat tema yaitu: ketenangan pikiran, perasaan bahagia, perilaku lebih sehat, kepercayaan diri meningkat. Kesimpulan: Tehnik fokus lima jari dapat dipergunakan untuk menurunkan kecemasan yang dialami oleh masyarakat yang berdampak terhadap bencana alam atau pandemi.
HUBUNGAN TINGKAT STRES REMAJA DENGAN PERILAKU BULLYING DI SMA NEGERI 06 SAMARINDA
Authors: Arief Ana Dwiyana , Dwi Lestari Novita 
Published: March 2024

ABSTRAK
Latar Belakang : Perilaku bullying masih sering ditemukan dilingkungan sekolah, remaja di sekolah belum dapat mengontrol dirinya sehingga terjadilah hal-hal yang dapat merugikan orang lain. Selain itu pada remaja mudah sekali mengalami stres dan mengganggu emosi pada remaja. Dampak stress pada remaja akan lebih sering mengganggu emosi, dimana remaja akan lebih cenderung mudah marah, kecemasan yang berlebihan terhadap segala sesuatu, merasa sedih dan depresi. Tujuan : untuk mengetahui hubungan tingkat stress remaja dengan perilaku bullying di SMA N 06 Samarinda. Metode : penelitian ini berjenis deskriftif analitik dengan pendekatan cross sectional (potong lintang), teknik pengambilan sampel Propotionate Stratified Random Sampling dengan jumlah sampel sebanyak 105 responden menggunakan instrument tingkat stress DASS-21 dan instrument perilaku bullying. Hasil : Remaja dengan tingkat stress berat sebanyak 68 responden 64.8 % remaja dengan perilaku bullying rendah yaitu sebanyak 58 orang dengan persentase 55,2%, dan terdapat 47 responden dengan perilaku bullying yang tinggi dengan persentase 44,8%. Remaja dengan tingkat stres berat memiliki perilaku bully yang tinggi yaitu sebanyak 36 remaja, Pada hasil uji chi square nilai sebesar 0.038 (ρ < 0,05) secara statistic Ha diterima yang berarti terdapat hubungan antara tingkat stress dengan perilaku bullying di SMAN 06 Samarinda. Kesimpulan : terdapat hubungan antara tingkat stress dengan perilaku bullying di SMAN 06 Samarinda.
Kata Kunci : Bullying, Remaja, Stress.
Antibacterial Activity Test Of Kecombrang Fruit (Etlingera elatior) Extracted Using Multiple Solvents
Authors: Elviana Elviana , Koapaha Teltje , Lalujan Lana E. 
Published: March 2024

The purpose of this study was to test the antibacterial activity of kecombrang fruit (Etlingera elatior) extracted using H₂O, ethyl acetate, and n-hexane as solvents. This study used a descriptive method with the type of solvent and kecombrang powder treatment respectively 25g:250g. The observation procedure was the calculation of the yield and diameter of the inhibition zone against Escherichia coli bacteria. Based on the yield calculation, it is known that H₂O, ethyl acetate, and n-hexane have average yield values of 11.8166%, 7.5536%, and 1.3038%, respectively. Antibacterial activity using ethyl acetate solvent resulted in an inhibition zone diameter of 33 mm, then H₂O solvent produced 28.25 mm while n-hexane did not have an inhibition zone diameter.
Keywords: Kecombrang, Extraction, Yield, Antibacterial
Abstrak
Tujuan dari penelitian ini yaitu untuk menguji aktivitas antibakteri buah kecombrang (Etlingera elatior) yang diekstrak dengan menggunakan pelarut H₂O, etil asetat, dan n-heksana. Penelitian ini menggunakan metode deskriptif dengan perlakuan jenis pelarut dan serbuk kecombrang masing-masing 25g:250g. Prosedur pengamatan yaitu perhitungan rendemen dan diamater zona hambat terhadap bakteri Escherichia coli. Berdasarkan hasil perhitungan rendemen diketahui bahwa H₂O, etil asetat, dan n-heksana memiliki nilai rata-rata rendemen berturut-turut 11,8166%, 7,5536%, dan 1,3038%. Aktivitas antibakteri menggunakan pelarut etil asetat menghasilkan diameter zona hambat 33 mm, kemudian pelarut H₂O menghasilkan 28,25 mm sedangkan n-heksana tidak memiliki diameter zona hambat.

Kata kunci: Kecombrang, Ekstraksi, Rendemen, Antibakteri
The Potential Of Army Worm Spodoptera frugiperda J.E. Smith, Control On Corn Plant Using Sex Pheromones
Authors: Mamahit Juliet Merry Eva , Pakasi Sandra , Rompas Joice , Paat Frangky J. 
Published: March 2024

The fall armyworm Spodoptera frugiperda J. E. Smith is an invasive pest of maize in Indonesia. The fall armyworm is a polyphagous pest originating from North America which was first discovered in West Africa. This pest control is very difficult because farmers are generally focused on the use of pesticides. For this reason, the method of using sex pheromones is an environmentally friendly alternative for controlling fall armyworm S. frugiperda pests. Innovation in the use of sex pheromones to act as attractants, mating disruption and mass trapping for controlling S. frugiperda pests.
Keywords: pheromone, fall armyworm, Spodoptera frugiperda, corn
Abstrak
Ulat grayak tanaman jagung Spodoptera frugiperda J. E. Smith merupakan hama infasif di Indonesia. Hama ulat grayak, merupakan hama polifag yang berasal dari Amerika Utara yang pertama kali ditemukan di Afrika Barat. Pengendalian hama ini sangat sulit karena petani umumnya terfokus pada penggunaan pestisida. Untuk itu metode pemanfaatan feromon sex merupakan alternatif untuk pengendalian hama S. frugiperda yang ramah lingkungan. Inovasi pemanfatan feromon sex berperan sebagai atraktan, mengganggu terjadinya kopulasi antara jantan dan betina dan perangkap masal untuk pengendalian hama S. frugiperda.
Kata kunci : feromon, ulat grayak, Spodoptera frugiperda, jagung
Physiological Qualities Of Polyembryony Seeds And Zigotes Of Nangka (Artocarpus integra (Thumb) On Seed Production
Authors: Walingkas Walingkas , Tumewu Pemmy , Rantung Meity Rosadelly 
Published: March 2024

The aim of this research is to determine the polyembryonic properties of jackfruit seeds, whether the resulting polyembryonic seeds can be used as a contributor to seed production, to determine the number of seeds produced from embryonic characteristics and to determine the relationship between polyembryony and seedling growth. The research used a Randomized Block Design (RAK) with 5 treatments each: whole jackfruit zygotic seeds 1 (Z1), whole jackfruit polyembryony seeds 2 (PU2), whole jackfruit polyembryony seeds 3 (PU3), split jackfruit polyembryony seeds 2 (PB2) and polyembryonic seeds of split jackfruit 3 (PB3). Variables observed included: plant height, stem diameter and number of leaves. Data were analyzed using analysis of variance and the Least Significant Difference Test (LSD) 5%.The results of research on the germination of jackfruit seeds in the zygote seed treatment (Z1), 2 whole and 2 split polyembryonic seeds had a viability above 80%, so they could be used as a seed source.
Keywords: Jackfruit, Polyembryony, Seed Production
Abstrak
Tujuan penelitian ini mengetahui sifat-sifat poliembrioni pada biji nangka apakah hasil biji poliembrioni yang dihasilkan dapat dijadikan sebagai penyumbang untuk produksi benih, mengetahui jumlah bibit yang dihasilkan dari sifat embrioni serta mengetahui hubungan antara poliembrioni dengan pertumbuhan bibit. Penelitian mengunakan rancangan Acak Kelompok (RAK) dengan 5 perlakuan masing-masing : benih Zigotik nangka utuh 1 (Z1), benih Poliembrioni nangka utuh 2 (PU2), benih poliembrioni nangka utuh 3 (PU3), benih poliembrioni nangka belah 2 (PB2) dan benih poliembrioni nangka belah 3 (PB3) Variabel yang diamati, meliputi: tinggi tanaman, diameter batang dan dan jumlah daun. Data dianalisis menggunakan analisis ragam dan Uji Beda Nyata Terkecil (BNT) 5 %. Hasil penelitian perkecambahan benih nangka pada perlakuan benih zigot (Z1), benih poliembrioni utuh 2 dan belah 2 mempunyai viabilitas diatas 80%, sehingga dapat dijadikan sebagai sumber benih.
Kata Kunci : Nangka, Poliembrioni, Produksi Benih