bluuebunny/crossref_metadata_2025_split huggingface dataset:
A bioinformatics-based analysis of chromatin regulators in atrial fibrillation uncovers potential novel biomarkers and immune infiltration characteristics
Authors: Li Yue , Han Xiao , Wang Fei , Chen Mengxi 
Published: February 2024

Abstract

Objective: To identify potential novel biomarkers and characterize immune infiltration in atrial tissue of patients with atrial fibrillation (AF) through bioinformatics analysis.
Methods: Three AF datasets (GSE31821, GSE41177, and GSE79768) from the Gene Expression Omnibus (GEO) database were integrated to identify differentially expressed genes(DEGs) related to chromatin regulators(CRs). Functional and pathway enrichment analyses were undertaken using GO,DO,and KEGG.10 hub genes from the protein-protein interaction (PPI) network of DEGs were utilized to predict possible drugs and miR-RNA.Furthermore,gene set enrichment analysis (ssGSEA) method was used to analyse immune cells immune infiltration in AF and identifythe most signifcant potential biomarkers.Finally,Diagnostic model was constructed to predict the individual risk of AF.
Results: A total of 77 DEGs related to CRs were identifed in AF patients compared with control group.Six hub DEGs(RBBP4, KAT7,KANSL2, ACTB, TRRAP,and KAT2B) and fourimmune cell subpopulations (tumor-infiltration lymphocyte ,master cells, neutrophils, regulatory T cells) were identifed as the most signifcant potential regulators.Hsa-miR-142-3p,hsa-miR-639,hsa-miR-3681,and hsa-miR-4280 were selected as potential therapeutic targets at post-transcriptional level.Then,we predicted 4 potential small molecule drugs(STOCK1N-28457,diphenylpyraline,hesperetin,dorzolamide )
Conclusion: The DEGs related to CRs and immune cells identifed in our study may be critical in AF development and provide potential predictive markers and therapeutic targets for determining a treatment strategy for AF patients.
Prognostic value of red blood cell distribution width for mortality in patients with sepsis-induced cardiomyopathy: a propensity score-matched cohort study
Authors: Liao Jian , Lu Dingyu , Zhang Lian , Wang Maojuan 
Published: February 2024

Abstract

Background The potential association between red blood cell distribution width (RDW) at admission and prognosis in patients with sepsis-induced cardiomyopathy(SIC) remains uncertain. The purpose of this study was to explore the prognostic value of RDW on mortality in patients with SIC.
Methods Data for this retrospective study were obtained from the MIMIC IV2.2 database.
We used propensity score matching (PSM) and Cox proportional hazards regression analysis to evaluate the main risk factors associated with mortality in SIC patients. This analysis was utilized to develop a predictive nomogram. To assess the predictive accuracy and clinical usefulness of the model, we employed the concordance index (C-index) and decision curve analysis. To define the high- and low-RDW groups among patients with SIC, we determined the optimal cut-off value by maximizing the Youden index.
Results According to the screening criteria, we identified a cohort of 1051 patients diagnosed with SIC. When comparing the high-RDW group to the low-RDW group, it was found that the high-RDW group exhibited longer Los_ICU(4.5 days vs.3.8 days ,respectively, P =0.009) and higher mortality rates at 28 days (33.8% vs. 7.8%, respectively, P <0.001). A nomogram model was created using matched patients which included various factors such as Age, RDW, LDH, CKMB, creatinine and the administration of β-blocker. The C-index predicting 28-day survival probability was 0.846. Decision curves analysis demonstrated that the inclusion of RDW in the model provided a greater net benefit compared to excluding RDW.
Conclusion The prognosis of patients with SIC can be predicted by the RDW value. The nomogram model provides a useful tool in identifying and managing SIC patients.
Takayasu's arteritis associated with tuberculosis: a distinct disease endotype
Authors: Pedreira Ana Luisa Souza , Figueiroa Maria de lourdes Castro de Oliveira , Miranda Mariana Oliveira , de Santana Alisson Regis , Mattos Victor Pereira , Paz Adriane Sousa da , Duran Camila Cendon , Santiago Mittermayer Barreto 
Published: February 2024

Abstract
Background: Takayasu arteritis (TA) and tuberculosis (TB) share similar histopathological and immunological characteristics. Studies comparing patients with TA with or without active or latent TB infection (LTBI) have revealed some differences. This study compared the clinical and radiological features of patients with TA with and without active TB or LTBI.
Methods: We retrospectively analyzed the secondary data of patients with TA at a public tertiary referral outpatient clinic in northeast Brazil from January 2017 to June 2022. Of these, 50 met the eligibility criteria, and an association with TB was identified in 20 patients (40%; active TB in six and LTBI in 14).
Results: Weight loss was more common in patients with TA and TB (p = 0.005). No significant intergroup differences were noted in terms of comorbidities, medications, erythrocyte sedimentation rates, or C-reactive protein levels. Significant differences were found in abdominal aortic involvement (25% of patients with TA and TB; p = 0.013). Dilations (25%) and aneurysms (15.9%) were significantly more common in patients with TA and TB (p = 0.009 and p = 0.027, respectively).
Conclusion: Patients with TA and TB have a higher prevalence of dilatation and aneurysms, most commonly in the abdominal aorta. TA with active TB or LTBI represents a distinct endotype in which vasculitis may arise after an infectious trigger.
TEA SOIL: Self-Power IoT for Precision Soil Farming of Tea Plant Cultivation
Authors: G Santhiya , A Radhakrishnan 
Published: February 2024

Abstract
In agriculture identifying the "nature of the soil" is a significant phase for serval sorts of landscapes. Even though numerous studies have been conducted for continuous soil health monitoring, however, existing techniques face challenges like labor-intensive, cost efficiency, need extensive field sampling and not suitable for tracking of soil parameters. To overcome these issues this paper proposed a novel IoT-based TeaSoil for precision soil monitoring of tea plant cultivation. The proposed TeaSoil’s end nodes are known as Tea Soil Monitoring Units (TSMU), are solar-powered and placed up for extended periods of time. The TSMU wirelessly sends soil NPK sensor, soil temperature, moisture, pH, organic matter, zinc, copper, iron, magnesium, manganese, carbon dioxide (CO2), and geo-location data using SigFox communication. SigFox receives the data and uploads it to the cloud server for data storage and analysis over a long period of time. On this receiver side, the soil classification is carried out using a deep learning-based EfficientNet for tea plant cultivation. A TSMU dashboard allows users to examine gathered data. The proposed Tea soil achieves an overall accuracy of 99.15%. The accuracy of proposed techniques attains 0.75%, 2.16%, and 20.32% better than Fast R-BAG, CNN, and CSMO. It is demonstrated that the proposed TeaSoil is suitable for precision agriculture based on the experimental results.
Research on Information Management of Prefabricated Component Hoisting Construction Based on Dynamo
Authors: Xu Dian , Wang Wenbo , Yi Fei 
Published: February 2024

Abstract
The application of Building Information Modeling (BIM) in the management of prefabricated component lifting operations in prefabricated construction can significantly improve construction efficiency. However, due to its high level of complexity and cost, it has not been widely adopted. To address this issue, this study focuses on the research of lifting operation information management based on Dynamo. By integrating BIM, Dynamo and mobile information management servers, a comprehensive system for managing prefabricated component lifting operation information is created. First, the paper elaborates on the detailed process of prefabricated component lifting operation information management based on Dynamo, covering the construction preparation stage and the lifting construction stage. Subsequently, Dynamo is utilized to develop programs for information input and processing, component sorting, and component coding and QR code generation. Furthermore, a mobile information management server is employed to build an information management application. By scanning Dynamo-generated QR codes, workers can access basic information about components, as well as upload construction and quality inspection data. Furthermore, this application facilitates information sharing and real-time data collection. Finally, this method is tested in a case study involving the lifting operation of composite slabs. The results show that the management system developed based on Dynamo can effectively improve the efficiency of hoisting construction information management prefabricated components of modular construction, reduce management costs, and promote sustainable development of engineering construction.
Clarifying the anatomy of tetralogy of Fallot with S-shaped ascending aorta
Authors: Gupta Saurabh Kumar , Mukharjee Aprateem , Pandey Niraj Nirmal , Ramakrishnan Sivasubramanian , Kothari Shyam Sunder , Saxena Anita , Anderson Robert H 
Published: February 2024

Abstract

Background
We recently encountered several cases of tetralogy of Fallot with an abnormally oriented S-shaped ascending aorta. In this retrospective study, we sought to clarify morphology of this unusual under-recognized variant.
Methods and results
Databases were reviewed to identify all patients with tetralogy of Fallot having an S-shaped ascending aorta. Computed tomographic angiography was used for the assessment of cardiac morphology. Out of the 21 patients, 18 (86%) had a right aortic arch, 2 (9%) had a left aortic arch, and the remaining patient (5%) had a double aortic arch. Patients with a right aortic arch, compared to age and sex-matched patients with a right aortic arch but normally oriented ascending aorta, had lesser aortic override (29.3±14% vs 54.8±13.2%; p = 0.0001) and a wider ascending aorta (25.2±6.9 vs 18.0±3.2 mm; p = 0.0003). The S-shaped ascending aorta was located posteriorly, with a higher sterno-aortic distance (25.5±7.7 vs 9.9±4.5 mm; p = 0.0001). The ascending aorta was longer (4.12±1.7 vs 3.07±0.82, p = 0.03) but with similar tortuosity index (1.22±0.19 vs 1.15±0.17, p = 0.23). Of the cases with right aortic arch and S-shaped ascending aorta, 16 (89%) had extrinsic compression of the right pulmonary artery (p = 0.0001), while 7 (39%) had crossed pulmonary arteries (p = 0.008), with no such findings among those with normally oriented ascending aorta.
Conclusion
Tetralogy of Fallot with an S-shaped ascending aorta is a variant with lesser aortic override and a more posteriorly located ascending aorta. Compression of the right pulmonary artery and crossed pulmonary arteries is frequent in the presence of a right-sided aortic arch.
Direct and Reagentless Atmospheric Pressure Photoionisation Mass Spectrometry: Rapid and Accurate Differentiation of Cystic Fibrosis Related Bacteria by Monitoring VOCs
Authors: Haworth-Duff Adam , Smith Barry L. , Sham Tung-Ting , Boisdon Cedric , Loughnane Paul , Burnley Mark , Hawcutt Daniel B. , Raval Rasmita , Maher Simon 
Published: February 2024

Abstract

Breath analysis is an area of significant interest in medical research as it allows for non-invasive sampling with exceptional potential for disease monitoring and diagnosis. Volatile organic compounds (VOCs) found in breath can offer critical insight into a person’s lifestyle and/or disease/health state. To this end, the development of a rapid, sensitive, cost-effective and potentially portable method for the detection of key compounds in breath would mark a significant advancement. Herein we have designed, built and tested a novel reagent-less atmospheric pressure photoionisation (APPI) source, coupled with mass spectrometry (MS), utilising a bespoke bias electrode within a custom 3D printed sampling chamber for direct analysis of VOCs. Optimal APPI-MS conditions were identified including bias voltage, cone voltage and vaporisation temperature. Calibration curves were produced for ethanol, acetone, 2-butanone, ethyl acetate and eucalyptol, yielding R2 > 0.99 and limits of detection < 10 pg. As a pre-clinical proof of concept, this method was applied to bacterial headspace samples of Escherichia coli (EC), Pseudomonas aeruginosa (PSA) and Staphylococcus aureus (SA) collected in 1 L Tedlar bags. In particular, PSA and SA are commonly associated with lung infection in cystic fibrosis patients. The headspace samples were classified using principal component analysis with 86.9% of the total variance across the first three components and yielding 100% classification in a blind-sample study. All experiments conducted with the novel APPI arrangement were carried out directly in real-time with low-resolution MS, which opens up exciting possibilities in the future for on-site (e.g., in the clinic) analysis with a portable system.
A retrospective analysis of drugs associated with the development of cutaneous squamous cell carcinoma reported by patients on the FDA’s adverse events reporting system
Authors: Jean-Pierre Philippe , Nouri Keyvan 
Published: February 2024

Abstract

Cutaneous squamous cell carcinoma (cSCC) is the second most common type of skin cancer arising from squamous cells of the epidermis. Most cases of cSCC have a good prognosis if detected and treated early; however, certain cases can be aggressive. The primary risk factor for cSCC is prolonged ultraviolet radiation from sun exposure, leading to DNA mutations. Other risk factors have also been observed, including adverse reactions to medications, particularly immunosuppressants. A query of the Food and Drug Administration Adverse Events Reporting System (FAERS) was done, and all reported events of cSCC as adverse events to medication were recorded along with demographic data of patients affected. A total of 4,792 cases of cSCC as an adverse event to medication were reported between 1997–2023. Lenalidomide, a chemotherapeutic drug, had the most cases of cSCC as an adverse event. Nine of the top 10 drugs associated with cSCC had immunosuppressive characteristics. While males had higher odds of cSCC associated with corticosteroids and calcineurin inhibitors, females had higher odds of cSCC related to monoclonal antibodies. Geriatric patients accounted for the majority of cSCC cases at 59.7%. Drawing on data from the FAERS database, there’s been a consistent increase in cSCC cases as a side-effect to certain medications, with most having immunosuppressive characteristics. Since there is a lack of up-to-date literature overviewing the most implicated medications for cSCC, we aimed to illustrate this better, as well as patient demographics, to better guide clinicians when prescribing these medications.
Evaluating the causes of retinopathy of prematurity relapse following intravitreal bevacizumab injection
Authors: Milani Amir Eftekhari , Arasteh Amin , Saeedi-Maleki Zahra , Brumandpur Fariborz 
Published: February 2024

Abstract
Background
Retinopathy of prematurity (ROP) is a proliferative disorder of the developing retina. Intravitreal bevacizumab injection (IVB) is an emerging treatment for ROP is one of the treatments for ROP has many benefits. The present study aimed to determine and evaluate the risk factors for ROP recurrence following IVB injection.
Materials and method
In this retrospective study, 98 eyes of 49 infants with ROP who had received IVB injections as the primary treatment for type 1 ROP are included.
Results
Fifty-four eyes (55.1%) had Aggressive posterior retinopathy of prematurity (APROP), and forty-four (44.9%) had Stage III Plus ROP in Zone II. ROP recurred in 13 eyes (13.26%) of 8 infants. The mean period between IVB and the ROP recurrence was 8.08 (95% CI:5.32–10.83) weeks. The infants who had ROP recurrence had lower birth weight (P value = 0.002), lower postmenstrual age at IVB injection (P value = 0.001), lower IVB injection gap period from birth (P value = 0.044), higher oxygen therapy requirement rate after IVB injection (P value < 0.001, OR:19.0) and higher oxygen therapy duration (P value = 0.006). The ROP severity, gestational age at birth, and diet were not statistically different between the recurrence and complete regression groups. Out of 13 eyes treated with laser photocoagulation because of ROP relapse, macula dragging occurred in one eye, and all the cases met the complete regression.
Conclusion
Low birth weight and oxygen therapy are the most important risk factors for ROP relapse, which requires meticulous oxygen treatment guidelines for premature infants.
Generation of a new DiCre expressing parasite strain for functional characterization of Plasmodium falciparum genes in blood stages
Authors: Bansal Abhisheka , Sharma Manish , Choudhury Himashree 
Published: February 2024

Abstract
Conditional regulation is a highly beneficial system to study the function of essential genes in different organisms. Dimerizable Cre recombinase is one of the recently adapted conditional regulation system that has gained huge popularity for the study of essential genes in Plasmodium falciparum. Inactive fragments of Cre are reconstituted to form a functionally active enzyme in presence of rapamycin. Different loci have been targeted for generation of parasite lines that express DiCre enzyme. Here, we have used marker-free CRISPR-Cas9 gene editing to integrate DiCre cassette in a redundant cg6 locus. We have shown the utility of the newly generated ∆cg6DC4 parasites in mediating robust, rapid and highly specific excision of exogenously expressed gfp sequence. The ∆cg6DC4 parasites are also capable of conditional excision of an endogenous parasite gene, PF3D7_1246000. Conditional deletion of PF3D7_1246000 did not cause any inhibition in the asexual proliferation of the parasites. Furthermore, the health and the morphology of the mutant parasites was comparable to that of the control parasites in Giemsa smears. Availability of another stable DiCre parasite strain competent for conditional excision of target genes will expedite functional characterization and validation of novel drug and vaccine targets against malaria.
An innovative method for estimating settling velocity of particles in stormwater using absorbance measurements and modelling
Authors: Haghighatafshar Salar , Hallinger Emma , Espinoza Daniel , Al-Rudainy Basel 
Published: February 2024

ABSTRACT

The purpose of the study was to develop a simple and rapid method for measuring the average settling velocity of particles in stormwater ponds. Water samples with suspended particles were collected from the bottom of a stormwater pond in Lund, Sweden. The absorbance in various samples was measured over 24 h (at 600 nm wavelength) and then translated into total solids concentrations. A one-dimensional model based on the Mason–Weaver equation was coded in Python and solved. The absorbance measurements were used to calibrate the model, thereby quantifying settling velocities and dispersion coefficients for samples from different zones of the stormwater pond. The quantified settling velocities ranged from 40 to 200 mm/h for fast-settling particles and from 2 to 8 mm/h for slow-settling particles. The developed methodology provided a mass estimate of the two modelled particle groups (i.e., fast- and slow-settling particles). Based on the model estimates, fast-settling particles dominated all samples, constituting 70–90% of the total solid mass. Due to its simplicity and inexpensiveness, this methodology is a potential alternative to more demanding and complicated methodologies used for measuring particle velocities in sedimentation systems.
Antipsychotics in Alzheimer’s Disease: Current Status and Therapeutic
Alternatives
Authors: Maziero Maria Paula , Rocha Natalia P. , Teixeira Antonio L. 
Published: February 2024

Abstract:
Psychosis and hyperactive behaviors, such as agitation and wandering, affect a significant
proportion of patients with Alzheimer’s disease (AD). These symptoms are often treated with
antipsychotics, usually in an off-label approach. This mini-review provides an updated perspective
on the pharmacological approach for the neuropsychiatric symptoms (NPS) in AD. The results of
new studies have provided a better understanding of AD-related NPS management, but high-quality
evidence still needs to be obtained. Herein, we argue for a more cautious approach to the use of
antipsychotics in AD and highlight the importance of exploring alternative treatments for NPS. By
doing so, we can ensure that patients with AD receive optimal care that is both effective and safe.
Characterization of Intrinsically Disordered Proteins in Healthy and
Diseased States by Nuclear Magnetic Resonance
Authors: Shahrajabian Mohamad Hesam , Sun Wenli 
Published: February 2024

Introduction:
Intrinsically Disordered Proteins (IDPs) are active in different cellular
procedures like ordered assembly of chromatin and ribosomes, interaction with membrane, protein,
and ligand binding, molecular recognition, binding, and transportation via nuclear pores, microfilaments
and microtubules process and disassembly, protein functions, RNA chaperone, and
nucleic acid binding, modulation of the central dogma, cell cycle, and other cellular activities,
post-translational qualification and substitute splicing, and flexible entropic linker and management
of signaling pathways.

Methods:
The intrinsic disorder is a precise structural characteristic that permits IDPs/IDPRs to be
involved in both one-to-many and many-to-one signaling. IDPs/IDPRs also exert some dynamical
and structural ordering, being much less constrained in their activities than folded proteins. Nuclear
magnetic resonance (NMR) spectroscopy is a major technique for the characterization of
IDPs, and it can be used for dynamic and structural studies of IDPs.

Results and Conclusion:
This review was carried out to discuss intrinsically disordered proteins
and their different goals, as well as the importance and effectiveness of NMR in characterizing intrinsically
disordered proteins in healthy and diseased states.
Analysis of Developing Anti-Corruption Education in Indonesia Through Media-Based Citizenship Education Learning Smart Mobile Civic
Authors: Trisiana Anita , Priyanto Anang , Sutoyo Sutoyo 
Published: February 2024

The purpose of this study is to analyze the development of anti-corruption education in Indonesia, through learning Citizenship Education based on Smart Mobile Civic media. Efforts to eradicate corruption are not only the responsibility of law enforcement agencies or the government, but also the responsibility of all components of the nation. Therefore, efforts to eradicate corruption must be carried out by involving all relevant stakeholders, namely the government, the private sector and the community. This research method uses a qualitative approach. The use of qualitative methods in research can produce a more comprehensive study of a phenomenon. The results of the study show that: Citizenship Education learning system has a very strategic role, to increase students' understanding of anti-corruption education. In this context of research, the students, as agents of corruption prevention, cannot be separated from the characteristics they possess, such as: Intellectuality, Youth Spirit, and Idealism. Student involvement in the anti-corruption movement can basically be divided into four areas: within the family, on campus, in the local community, and at the regional or national level. The digital era has had a tremendous impact on citizenship learning, such as through the application of Smart Mobile Civic media as a fun and not boring learning media for students so that they can explore more deeply about their knowledge and experiences.