bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormalities in the functional activity of neural networks in a human iPSC model of Dravet syndrome
Authors: Mzezewa Ropafadzo , Hyvärinen Tanja , Vinogradov Andrey , Pesu Emma , Isosaari Lotta , Kulta Oskari , Vuolanto Valtteri , Kapucu Fikret Emre , Schuster Jens , Dahl Niklas , Narkilahti Susanna 
Published: February 2025

Abstract

Dravet syndrome (DS) is a severe pediatric epilepsy with a limited response to current antiseizure medications. Majority of DS cases are caused by a de novo mutation in the SCN1A gene, encoding the alpha subunit of the voltage-gated sodium channel. While early in vivo studies have shown that DS pathology results from the disinhibition of GABAergic inhibitory neurons, recent studies report alterations in sodium currents in both excitatory and inhibitory neurons. Investigating the excitatory-inhibitory interplay is essential for elucidating the functional alterations caused by SCN1A mutations. Here, the aim was to study how different SCN1A gene pathogenic variants affect the functional phenotype of DS human induced pluripotent stem cell-derived neuronal networks in enriched GABAergic cultures and heterogeneous glutamatergic and GABAergic cultures, using microelectrode arrays (MEAs). We report functional differences in patient-derived GABAergic cultures. In heterogeneous cultures, DS patient-derived neurons displayed altered activity with prominent network bursts and overall, the altered functional activity correlated with the clinical severity of the disease. Principal component analysis revealed distinct clustering between the DS patient and control heterogeneous cultures. Thus, pathogenic SCN1A variants alter the neuronal network functionality suggesting that heterogeneous cultures are competent physiological models for characterizing disease phenotype alterations in DS using MEAs.
Epidemiological Characteristics and Temporal Trends of Malignant Melanoma from 1990 to 2021, with Projections until 2044
Authors: Yao Ling , Li Yonghai , Li Huashang , Qian Guixiang , Zhang Zhuhui , Quan Longfang , Liu Qiuling , Dai Jie , Lei Xuedi , Jia Xiaoqiang 
Published: February 2025

Abstract

OBJECTIVE
Malignant melanoma, one of the most metastatic human cancers, is on the rise globally. However, its low prevalence leads to insufficient concern and its latest worldwide burden remains unclear. This study aims to update its epidemiological features to prompt timely and impactful interventions.
METHODS
Weanalysed malignant melanoma incidence, disability-adjusted life years (DALYs), and mortality trends from 1990 to 2021 across 204 countries using GBD 2021 data. We also projected incidence and mortality rates for the next two decades.
RESULTS
Globally, the age-standardized incidence rate (ASIR) of malignant melanoma in 2021 was 3.6 per 100,000 people with the estimated annual percentage change (EAPC) of the ASIR from 1990–2021 was 0.6%. The age-standardized DALYs rate (ASDR) of malignant melanoma in 2021 was 19.6 per 100,000 people with the ASDR EAPC from 1990 to 2021 was -0.7%. The age-standardized mortality rate（ASMR）of malignant melanoma in 2021 was 0.7 per 100,000 people with the ASMR EAPC from 1990 to 2021 was -0.4%. Australia remained the region with the highest ASIR, ASDR, and ASMR in 2021. Older adult males had higher rates than females for all three measures.
The incidence of MM is predicted to remain stable over the next twenty years while the mortality rate will significantly decline.
CONCLUSION
The global ASIR of malignant melanoma increased from 1990 to 2021, while the ASDR and ASMR decreased during the same period. High-SDI countries and older adult males require enhanced measures for the prevention and control of malignant melanoma.
Synergy of a Complimentary Ionic Biogel Network for Through-Hair Neurohaptics
Authors: Cheng Huanyu , Dutta Ankan , Biswas Md Abu Sayeed , Meng Long , Gerhard Ethan , Calva Arantza Moreno , Zhang Wanqing , Abdullah Abu Musa , Joharji Lana , Che Yuju , Yang Jian , Hu Xiaogang 
Published: February 2025

Abstract

Understanding the neural mechanisms underlying haptic sensations is crucial for advancing neuroprosthetics. However, achieving on-site amplification non-invasively through-hair neural recordings remains a significant challenge as it requires thermoreversible, bioadhesive, and semiconducting characteristics in the same material. Typical polymer composite compromises on complementary properties. To address this, we present a membraneless organelles - inspired ionic biogel that leverages liquid–liquid phase separation. This enables a unique synergy of complementary properties, including rapid thermoreversible transitions, p-type semiconductivity, thermoelectricity, enhanced electrochemical stability, self-healing, and bioadhesive capabilities. These characteristics enable to analyze the frequency dependence of event-related desynchronization during electrical stimulation over days mimicking the frequency response of mechanoreceptors sensation. This thermoresponsive, semiconducting ionic biogel also enables a phase-reversible, self-balancing, tip-shaped vertical organic electrochemical transistor with a high transconductance of 44 mS at 40°C. The ionic biogel demonstrates synergistic complementary properties to understand through-hair neurohaptics.
Strain-Driven Oxygen Vacancy Ordering in LaNiO3 Thin Films: Impact of Ruddlesden-Popper Faults
Authors: Banerjee Pritam , Orgiani Pasquale , Meingast Arno , Lazar Sorin , Sushko Peter , Spurgeon Steven , Ciancio Regina 
Published: February 2025

Abstract

The study of rare-earth nickelates, such as LaNiO3 (LNO), is significant due to their complex electronic properties. Ordered oxygen vacancies (OOV) in LaNiO3 − x decrease conductivity, converting it from metallic to insulating state as 'x' approaches 0.5, and semiconducting behavior near x = 0.75. These OOV also influence magnetic properties, causing LNO to exhibit anti-ferromagnetic and ferromagnetic behavior instead of its usual paramagnetic state. Interfacial strain in thin-film heterostructures is utilized to regulate the creation of oxygen vacancies and Ruddlesden-Popper (RP) faults, leading to notable impacts on materials' structural and electronic phases. The effect of strain on the formation of RP faults and the critical thickness of a fault-free layer in LNO has been studied, but atomic-scale insights into the relationship between strain, OOV, and RP faults are still limited. In this paper, we systematically investigated the effect of strain and RP faults on the formation of OOV in LNO thin films grown on SrTiO3 (STO) substrates. Using high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM) and integrated differential phase contrast (iDPC) STEM imaging, we conducted atomic-scale structural and compositional analyses of OOV. Geometric phase analysis (GPA) was employed to measure the strain in fault-free and RP fault regions, while density functional theory (DFT) calculations explored different OOV arrangements in the LNO phase. Simulated iDPC-STEM imaging of energy-stabilized structures was performed to correlate with experimental results. Our findings reveal superstructure modulation in the chemical composition and atomic-scale lattice structure in LNO, primarily due to the formation of the OOV in Ni-O layer of LaNiO2.5 phase. The out-of-plane compressive strain of about 2% stabilizes this phase, reducing the strain, diminishing OOV, and transforming them into LNO.
Mannanase from Lactic Acid Bacteria Pediococcus acidilactici: Production optimization, Purification and Application in juice clarification
Authors: Shi Jingjun , Chen Xi , Yang Ruoxi , Zhao Dan 
Published: February 2025

Abstract

Pediococcus acidilactici, a generally regarded as safe (GRAS) lactic acid bacteria species, is a desirable microbial mannanase source due to high bio-safety. P. acidilactici HDM2 isolated from dragon fruit culture was identified according to morphological, physiological and biochemical characters as well as preserved nucleic acid (16S rDNA and rpoA) sequencing. A two-step response surface methodology (RSM) experiment subsequently screened out and then predicted the optimal levels of two factors which significantly affected P. acidilactici HDM2’s mannanase production. The maximal enzyme activity reached 97.9 U/mL under the condition of glucose 17.5 g/L and initial pH 4.6. RSM optimization resulted in a 39.3% increase of mannanase yield which was verified by six repeated trials and consequent t-test (P < 0.05). The enhancement of mannanse production was also proved by congo-red dyeing on KGM (konjac glucomannan)-MRS (de Man, Rogosa and Sharpe) agar. Diameter of clearance zone enlarged from 2.7 cm to 4.5 cm through RSM. The purified P. acidilactici HDM2 mannanase with molecular weight of 30 KDa was then applied in fruit juice clarification process. The enzyme exhibited significantly higher clarifying efficiency than commercial mannanase in both yield and clarity for six out of eight fruits, i.e. orange, peach, grape, pear, kiwi and grapefruit. These results promised the application of P. acidilactici HDM2’s mannanase in various especially food-level field.
Using Bayesian Methods to Identify Predictors of Freshmen Attrition
Authors: Lauría Eitel J.M. 
Published: February 2025

Abstract

This study employs Bayesian hierarchical generalized linear models to investigate predictors of freshmen student attrition using Marist University student data from nine academic years (n=10921) and across its six schools. The proposed framework builds hierarchical binary logistic regression models to estimate the posterior probability distributions of models' parameters and derived metrics. The paper shows how to formulate hierarchical generalized (Bernoulli) linear models and implement them in a probabilistic programming platform to compute the models' parameters posterior distributions using Markov chain Monte Carlo (MCMC) techniques. Tests were carried out to study model fitness, parameter convergence and the significance of the regression parameter estimates.The results identify university academic performance, financial need, gender, and work-study program participation as predictors having a significant effect on the log-odds of freshmen attrition. Additionally, the study reveals fluctuations across time and schools. Such fluctuations would have been overlooked if flat, pooled regression models were used instead of the multilevel approach applied in this work. Variation of freshmen retention across schools highlights the need for retention-focused initiatives that include targeted strategies, as some schools seem to be more vulnerable to higher attrition rates than others. The research provides valuable findings to stakeholders, administrators, and decision-makers that can be applied and utilized by other institutions, as well as a detailed guideline on how to analyze educational data using Bayesian methods.
Investigation of Reservoir Properties, Sedimentary Environment, and Reservoir Modeling of Sarvak Reservoir Formation in a Southwestern Iranian Oil Field
Authors: Asghari Mohammad Reza , Jahani Davood , Arian Mehran , Sheikhzakariaee Seyed Jamal , Aleali Seyed Mohsen 
Published: February 2025

Abstract

The Late Albian-Early Cenomanian Sarvak Formation is a significant oil reservoir in the Zagros region of southwestern Iran. This study examines the reservoir characteristics, sedimentary environment, and modeling of the Sarvak Formation using seismic data from an Iranian field. A total of 11 facies were identified based on allocomes and orthocomes, indicating deposition in a homoclinal ramp environment across four sub-environments: outer ramp, middle ramp, and inner ramp. The reservoir quality of the Sarvak Formation is primarily influenced by sedimentary facies and diagenesis processes, which include bioturbation, micritization, chemical and mechanical compression, cementation, neomorphism, dissolution, porosity, dolomitization, and fracturing across marine, meteoric, and burial environments. Additionally, four discontinuities—Lower Cenomanian, Middle Cenomanian, Cenomanian-Turonian boundary, and Middle Turonian discontinuity—were identified based on ancient soil, shearing, meteoric porosity, and karstization. This study recognizes four sedimentary sequences: the Albian Barian-Lower Cenomanian, Middle Cenomanian, Barian Cenomanian, and Lower to Middle Turonian. All sequence boundaries are classified as SB1, except for the lower boundary of the first sequence, which is SB2. The TST sections of the first and second sequences show low reservoir quality, while the third and fourth TST sequences exhibit good to excellent reservoir quality due to supporting grain rudist facies. The third and fourth HST sequences provide the best reservoir quality in this formation. Under the discontinuities, meteorically influenced diagenesis processes have significantly increased mold porosity and extensive dissolution features.
Evaluation of water delivery performance of the Bontanga irrigation scheme in the Northern Region of Ghana
Authors: Sibale Davis , Kranjac-Berisavljevic Gordana , Abdul-Ganiyu Shaibu 
Published: February 2025

ABSTRACT

This study was undertaken at the Bontanga irrigation scheme in the Northern Region of Ghana to identify shortfalls within the irrigation water delivery system, propose solutions for the system's performance improvement, and project the impact of water delivery improvement on water demand using the Water Evaluation and Planning (WEAP) model. The study employed the following performance indicators; irrigation efficiencies, relative irrigation supply (RIS), irrigation ratio (IR), and sustainability of irrigated area index. The results showed average conveyance, distribution, application, and overall irrigation efficiencies of 85.6, 63, 58, and 31.30%, respectively. The low overall irrigation efficiency was attributed to underutilisation of flow measuring structures, poor canal maintenance, excessive canal tailwater losses, and poor water management at the field level. The RIS ranged from 1.02 to 1.09. The IR and sustainability of the irrigated area index were 62 and 100%, respectively. By improving the overall irrigation efficiency from 31.30 to 60%, the WEAP model projected that total seasonal water demand could drop by 16.50%, contributing to an average seasonal water saving of 3,894,597.86 m3 during the simulation period (2024–2030). Study findings will help irrigation managers and farmers to improve water delivery performance and sustainably meet the competing water demands.
Nucleic Acid-based Therapy in Effective Management of Rheumatoid Arthritis
Authors: Singh Yashpreet , Singh Aniket , Geoffrey Priscar , Chaitanya MVNL , Kaur Jaskiran 
Published: February 2025

Abstract:
Rheumatoid Arthritis (RA) is a chronic autoimmune disease that prominently affects the joints of
the body, including one or more types, such as wrists, knees, fingers, and toes. This condition is characterized
by specific auto-immune responses, i.e., inflammation, swelling, stiffness, and pain in the body's joints. This
results in partial or complete immobility. Several treatment options are available in the pharmaceutical market,
commonly immunosuppressants, anti-inflammatory drugs, corticosteroids, anti-antibody drugs, etc. However,
such drug treatments provide only symptomatic relief and lack long-term therapeutic efficacy. Thus, there is a
need to develop an alternative treatment option that potentially can cure this disease. Recently, researchers
have shifted their focus to targeting the root cause involved in the pathogenesis of RA by designing nucleic-acid-
based molecules. With this objective, we have provided this review in which we have explored the nucleic
acid-based techniques used to treat RA. Various molecular and genetic methods, including antisense oligonucleotides,
small interfering RNA (siRNA), CRISPR-Cas9 gene editing, RNA-based vaccines, microRNA (miRNA)
therapeutics, and epigenetic modifications are used to target the mechanisms underlying RA pathogenesis.
Through the extensive evaluation of clinical and preclinical studies, we reported nucleic acid-based therapy's
clinical efficacy, safety, and therapeutic benefits. In addition, this study states the associated pharmacokinetic
challenges followed by approaches to overcome them. Nucleic acid-based therapies are susceptible to
degradation by nucleases in the body and are not efficiently absorbed due to their considerable molecular
weight. Specialized carriers like nanoparticles are employed for their effective delivery. Nucleic acid-based
therapies hold immense potential for achieving more effective, less toxic, and patient-centric management of
RA, offering hope for improved outcomes and an enhanced quality of life for individuals living with this challenging
autoimmune condition.
Exploring self-victimhood’s place in moral personality and unethical organizational behavior
Authors: Wilmore Thomas , Kriletic Ana , Svyantek Daniel , Donnelly Lilah 
Published: February 2025

Recent research has shown that a tendency for interpersonal victimhood (TIV) predicts maladaptive thinking and antagonistic behavior. However, understanding TIV’s place in the nomological network of personality variables used to predict moral behavior in organizations. This paper attempted to bridge this gap by examining TIV’s associations with morally relevant personality traits and TIV’s prediction of unethical organizational behavior in two studies. For the studies, we relied on two samples of U.S. adults recruited via an online crowdsourcing platform (NTotal = 1,080) using survey methods. Study 1 (N = 485) showed that TIV had a sizeable loading onto an overarching Dark Factor of Personality (D), which contained TIV, the Dark Tetrad, and moral disengagement. Study 2 (N = 405-595) showed that TIV predicted counterproductive work behavior (CWB) and unethical pro-organizational behavior (UPB), even after controlling for morally relevant HEXACO traits and demographic variables. Supplemental analyses indicated that TIV’s rumination facet primarily drives its relationship with CWB, while its lack of empathy facet primarily drives its relationship with UPB. TIV tended to have small to moderate positive correlations with dark traits (e.g., the Dark Triad, moral disengagement) (r = 0.30-0.50) and small negative correlations with light traits (e.g., the Light Triad, Honesty-humility, moral identity-internalization). This research provides evidence supporting TIV’s place in the nomological network of moral personality and its influence on destructive organizational behavior.
SCREAM QUEENS: TEEN SERIAL KILLERS, TWITTER DEATHS AND TAYLOR SWIFT'S SOUNDTRACK
Authors: Frazão Pedro 
Published: February 2025

ABSTRACT:
This paper discusses the relevance of serial killers and psychopaths in contemporary narratives, presenting some strategies that have been used to maintain popular interest in these stories. It will present a concise history of this genre and how Ryan Murphy’s TV series Scream Queens offered some guidelines for the regeneration of serial killer and psychopath stories, for instance rethinking the moral values that identify the final girls and their antagonists. This article also analyzes extracts from the TV series, discussing its reference to Psycho among many other slashers and American horror movies.
Bibliotecas no Contexto da Agenda 2030 da ONU
Authors: De Sousa Pereira Eliete , Berrio Zapata Cristian 
Published: February 2025

O presente trabalho é uma revisão de literatura e analisa sete projetos bibliotecários com o objetivo de identificar, descrever e relacioná-los ao Objetivo do Desenvolvimento Sustentável (ODS), recomendados pela Federação Internacional das Instituições Bibliotecárias (IFLA) às bibliotecas. A metodologia utilizada foi a pesquisa bibliográfica de abordagem qualitativa e descritiva realizada na Base de Dados Referenciais de Artigos de Periódicos em Ciência da Informação (BRAPCI) e no Seminário Nacional de BibliotecasUniversitárias (SNBU), entre 2015 a 2021. Resultado: o estudo identificou que as bibliotecas contribuem para a melhorar a qualidade de vida dos cidadãos. Identificou-se como as principais atividades relacionadas as ODS dos projetos bibliotecários analisados: a educação de qualidade; a inclusão social e digital; cidades sustentáveis; paz, justiça e instituições eficazes. Conclusão: a classe bibliotecária tem se empenhado frente as recomendações da IFLA, porém o estudo revelou que é necessário maior engajamento da categoria.

Palavras-chave: Agenda 2030. Bibliotecas Sustentáveis. IFLA. Direitos Humanos. ONU.
Transcrição da Aula Magna Sobre Democracia e Crise Democrática
Authors: Ignowsky Borba Giovanna , De Oliveira Martins Victor 
Published: February 2025

A transcrição aqui apresentada resultou da gravação de uma das atividades que compuseram a Semana de Integração promovida pelo Centro Acadêmico Manoel Mattos (CAMM) do curso de Direito da Universidade Federal da Paraíba (UFPB), em Santa Rita, em parceria também com a Revista Direitos Humanos e Transdisciplinaridade (DHT). A ação-reflexão proposta pela Revista, tanto na organização da referida aula magna, quanto na transcrição das falas das convidadas, se encaixa em um contexto de reverter premissas normatizadas em torno das aulas magnas, quais sejam: 1) de que há um perfil pré-estabelecido de quem pode ser convidado para ministrar a aula; e 2) de que o tema central deva ser acerca de um tema jurídico considerado dogmaticamente relevante. Nesse sentido, no dia 02 de março de 2023, durante o turno da noite (18h-20h), no auditório do Departamento de Ciências Jurídicas (DCJ) do Centro de Ciências Jurídicas (CCJ) da UFPB, ocorreu uma aula magna sobre Democracia e Crise Democrática, que contou com as presenças convidadas de Ana Lia Almeida e de Heloisa de Sousa, com mediação do Coordenador Geral do CAMM à época e Editor-Chefe da Revista DHT, Victor de Oliveira Martins.

Palavras-chave: Democracia. Crise Democrática. Universidade. Educação. Direito.
Massacre do Carandiru
Authors: De Souza Santos Mauren Kelly , Ignowsky Borba Giovanna 
Published: February 2025

Este estudo se debruça sobre o caso do Massacre do Carandiru para investigar as violações de direitos humanos nas prisões brasileiras, a fim de entender o mecanismo que permite que, embora criminosas, tais violações continuem ocorrendo e se perpetuando dentro do sistema prisional do Brasil. Trata-se de uma pesquisa qualitativa e de caráter exploratório, que reuniu estudos acadêmico-científicos e livros que abordassem especificamente a violência carcerária. Os resultados indicam que, de forma geral, a forma como é construído o sistema de segurança público brasileiro produz e reproduz violências contra grupos marginalizados, permitindo que violações de direitos humanos se desenrolem dentro do sistema carcerário. Aponta-se, ainda, que as violações não são somente físicas, mas psicológicas e relacionais também, o que comprova a necessidade de se repensar o modelo de política de segurança pública pautado no punitivismo e segregação de determinados corpos.

Palavras-chave: Violência carcerária. Sistema prisional. Direitos humanos.
RECONHECIMENTO DO DIREITO HUMANO AO MEIO AMBIENTE EQUILIBRADO E SUA RELAÇÃO COM O RACISMO AMBIENTAL
Authors: Tatiane Brenna , Silveira Pertille Thais 
Published: February 2025

O reconhecimento do direito humano a um meio ambiente equilibrado representa um avanço fundamental na proteção da relação entre seres humanos e a natureza. Este artigo buscou entender a afirmação internacional de que a Resolução 48/13 estabelece tal direito e destaca o fenômeno do racismo ambiental. Utilizando raciocínios dedutivo e indutivo, metodologia monográfica e pesquisas bibliográficas, foram analisadas as consequências do posicionamento dos Estados ao incentivar a implementação de políticas públicas socioambientais. A questão central foi: qual é a relação entre a proclamação da ONU de um direito humano ao equilíbrio ambiental e o fenômeno do racismo ambiental? A partir dessa análise, é possível dialogar e identificar métodos e medidas que promovam o bem comum ao meio ambiente.

Palavras-chave: Direito humano. ONU. Racismo ambiental. Direito Internacional. Meio ambiente.