bluuebunny/crossref_metadata_2025_split huggingface dataset:
The (cost-)effectiveness of early intervention (MBT-early) versus standard protocolized treatment (CBT) for emerging borderline personality disorder in adolescents (the EARLY study): a study protocol for a randomized controlled trial
Authors: Remeeus Melissa , Clarke Sharon , Feenstra Dineke , Eeren Hester Van , Smits Maaike , Debruyne Sara , Kouijzer Mirjam , Luyten Patrick , Scholte Ron , Hutsebaut Joost 
Published: April 2024

Abstract
Background: Although clinical guidelines prioritize the treatment of depression and anxiety in young persons, there is accumulating evidence that the presence of symptoms of borderline personality disorder (BPD) is associated with limited effectiveness of these standard treatments. These findings stress the need for interventions addressing early-stage BPD in young people with presenting symptoms of anxiety and depressive disorders. The aim of this study is to investigate the (cost-)effectiveness of an early intervention program for BPD (MBT-early) compared to first-choice psychological treatment for depression and anxiety according to Dutch treatment guidelines (CBT), in adolescents with either depression, anxiety, or both, in combination with early stage BPD.
Methods: This study is a multi-centre randomized controlled trial. A total of 132 adolescents, presenting with either depression, anxiety, or both and significant BPD features will be randomized to either MBT-early or CBT. Severity of BPD, symptoms of depression and anxiety, personality, social and academic functioning, and quality of life will be assessed at baseline, end of treatment, and at 12-, 18-, and 24-monts follow-up, along with medical costs and costs of productivity losses for cost-effectiveness analyses.
Discussion: This study will provide an empirical evaluation of the potential surplus value of early intervention in young people for whom treatment oriented at common mental disorders like anxiety and depression may be insufficient given their underlying personality problems.
Trial registration: Netherlands Trial Register: NL9569. Registered June 15, 2021.
Prognostic factors for the long-term survival of primary molars following chairside pulpectomy with Vitapex: a retrospective study
Authors: Xiao Ling , Zhao Xi , Ye Lin , Zhou Dan 
Published: April 2024

Abstract
Objectives The objective of this study is to evaluate the potential factors that could influence the long-term survival of primary molars after pulpectomy with Vitapex.Materials and Methods A total of 212 primary molars underwent pulpectomy at the Department of Pediatric Dentistry from January 2018 to December 2020 were analyzed in this retrospective study. Kaplan-Meier analyses were utilized to evaluate time until failure. Multivariate Cox regression analysis was conducted to evaluate the clinical factors associated with failures.Results The survival rate was 86.8% at 12 months, declining to 49.5% at 24 months, and further decreasing to 3.3% at 48 months. In the multivariate Cox regression analysis, children aged 5 to 7 had a hazard ratio of 2.10 (P = 0.003), while those aged 7 or older had a significantly higher hazard ratio of 4.40 (P < 0.001) compared to children under 5 years old. Primary molars with a mucosal fistula have a 2.61 times (P = 0.004) higher risk of failure compared to those without this condition .Conclusions The age at initial treatment and the presence of a mucosal fistula before treatment are crucial factors for predicting the outcomes of Vitapex pulpectomy in primary molars and assessing the likelihood of treatment failure.Clinical relevance The apical seal and the extent of apical infection before treatment significantly impact survival rates following pulpectomy of primary molars. Evaluating these variables is crucial for evidence-based clinical decisions.
Lipid metabolism and renal function changes switching from Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide therapy in CHB patients
Authors: Lai Ruimin , Wang Longfei , Li Na , Lin Shan , Chen Tianbin , Lin Xiaoyu , Jiang JiaJi , Zheng Qi 
Published: April 2024

Abstract
BACKGROUND
Tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF) are common antiviral treatments for chronic hepatitis B (CHB) patients. The effects of TAF therapy have not been clarified.
AIM
The study aimed to evaluate the changes caused by switching from TDF to TAF therapy, specifically on lipid metabolism and renal function in CHB patients.
METHODS
In this retrospective study, CHB patients receiving antiviral therapy, who were either switching from TDF to TAF therapy or continuing on TDF therapy were enrolled. Laboratory parameters were evaluated at baseline and 48 weeks after the enrollment.
RESULTS
Of 281 patients, the mean age was 43.02 years, with 73.31% males represented. One hundred fifty patients switched from TDF to TAF. After 48 weeks of post-enrollment treatment, total cholesterol (TCHO) and high density lipoprotein (HDL) profiles of the TAF group were increased compared with those continuing TDF therapy (4.58±0.88 vs 4.09±0.66, P=0.000; 1.31±0.35 vs 1.17±0.32, P=0.001; respectively). Additionally, the post-treatment TCHO level were significantly elevated compared with baseline levels (4.58±0.88 vs 4.47±0.87mmol/L, P=0.038) in the TAF-switching group. However, TCHO levels were significantly lower than at baseline levels in the continuing TDF group (P<0.002). Similarly, (low-density lipoprotein) LDL (P<0.042) and HDL (P<0.000) were also lowered in the continuing TDF group. Non-alcoholic fatty liver disease (NAFLD), baseline TCHO, baseline fasting blood glucose (FBG) and creatinine (CREA) were associated with the elevated TCHO in the TAF-switching group according to multivariable analysis. An increase in TCHO level was observed in CHB patients switching to TAF therapy after 48 weeks, though no significant changes in CREA or glomerular filtration rate (GFR) were observed compared with continuing TDF therapy.
CONCLUSION
This real-life retrospective cohort study of Chinese patients found a significant association of TAF on increasing serum lipid TCHO in CHB patients after 48 weeks of therapy. It is worth further exploring whether it is necessary to indiscriminately switch to TAF due to fear of the risk of kidney impairment.
Thyrotropin (TSH) and thyroid autoimmunity are predictive factors for the incidental discovery of papillary thyroid microcarcinoma during thyroidectomy
Authors: Kyrilli Aglaia , Schoinochoriti Raffaella , Chatzopoulos Valerie , Bahar Nabila , Bouziotis Jason , D'Haene Nicky , Salmon Isabelle , Ruiz Maria , Corvilain Bernard 
Published: April 2024

Abstract

Purpose: To identify clinical, biological and pathological risk factors for the incidental discovery of papillary thyroid microcarcinomas (PTMCs) in patients undergoing thyroidectomy for presumed benign conditions.
Methods: Cross sectional, single center study, involving all consecutive patients (N=3015) who were submitted to thyroid surgery between 2001-2019. All medical files were retrospectively reviewed. A total of 1961 patients in the benign group and 145 patients in PTMC group were analyzed.
Results: No significant differences in age, sex, body mass index, smoking status, thyroid volume or weight and preoperative thyroxine treatment between benign and PTMC groups were observed. Circulating anti- thyroid antibodies, histological thyroiditis and serum thyrotropin (TSH) were significantly associated with PTMC in univariable analysis. Independent risk factors for incidental PTMC by multivariable analysis where possible (OR: 1.51, 95% CI: 0.99 - 2.28) and certain (OR: 1.74, 95% CI: 1.09 - 2.78) thyroid autoimmunity (p= 0.002) and higher serum TSH (OR: 1.25, 95% CI: 1.08 -1.45, p= 0.03), whereas thyroid lobectomy was associated with a lower risk of PTMC (OR: 0.40, 95% CI: 0.24 - 0.67, p< 0.001). The most frequent genetic alteration was BRAFV600E mutation, found in 56.3 % of PTMC submitted to DNA sequencing. No association between clinical, biological or histological characteristics of PTMC and BRAFV600E mutation was observed.
Conclusions: Thyroid autoimmunity and higher preoperative serum TSH level were independent predictors of PTMC incidentally discovered during thyroid surgery. Larger prospective studies are needed to better identify possible risk factors for papillary thyroid carcinoma initiation and progression.
Vibration control of a cantilever beam coupled with MTNES
Authors: Fu Jundong , Wan Shui , Li Wenke , Shen Jiwei , Venugopal Harikrishnan , Loccufier Mia , Dekemele Kevin 
Published: April 2024

Abstract
In response to limitations in vibration suppression performance of traditional tuned mass damper (TMD) and conventional nonlinear energy sink (NES) due to energy threshold constraints and narrow vibration bands, this study proposes a magnet tri-stable NES (MTNES) formed by combining a linear spring and magnets. The mechanism of the MTNES is first introduced in this study, which reveals the existence of the three stable points in the system. Subsequently, the equations of motion of the coupled system with MTNES attached to the cantilever beam are derived, and the optimal parameter combination for MTNES is determined using a global optimization method. Furthermore, the influence of MTNES parameter variations on vibration suppression efficiency is studied through parameter analysis, revealing the robust nature of the MTNES. Then, the restoring force of the MTNES is simplified into polynomial form, and the system response is analyzed by using the harmonic balance method and Runge-Kutta method. Finally, experimental studies on the coupled system are conducted. The results indicate that MTNES can effectively suppress the resonance of the host structure within a wide frequency band, with the highest vibration suppression rate of up to 66% under strong modulated response. Additionally, the results of numerical calculations and theoretical analysis are in good agreement with that of the experiment.
“I really hate it” - Menstruation Experience and Practices among Female Tertiary Students in Hohoe Municipality, Ghana
Authors: Wuresah Israel , Ankrah Esther Twumasi , Klutse Priscilla , Gbogbo Emmanuel , Kugbey Nuworza , Gbogbo Sitsofe 
Published: April 2024

Abstract
In low- and middle-income settings, myths, taboos, and socio-cultural restrictions create barriers for menstruating individuals to acquire accurate information about menstruation, and this limit their daily and routine activities, and have the potential to negatively affect their self-esteem, reproductive health, and schooling. The ‘socio-menstrual’ milieu - beguiled with discrimination, stigmatization, heavy presence of myths and misconceptions, and social exclusion of the menstruating woman - have profound implications that form the experiences of menstruating women and inform the quality of menstruation management practices. More often than usual, studies exploring menstrual experiences and management practices are conducted among females in lower grades limiting the holistic understanding of menstrual hygiene management experiences and challenges among females in higher institutions of learning. This study mainly focused on uncovering the essence and nature of menstruation experiences and management practices through in-depth interviews using the phenomenological research design in a qualitative approach. Four tertiary institutions and 20 participants were conveniently and purposively selected respectively to participate in the study. Data transformation and thematic analysis were carried out using the MAXQDA version 2020 software. The findings showed that most participants were aged above 20 years, with a few either in a cohabiting relationship or married. Majority of the participants identified with the Christian religion. In terms of living arrangements, most (60%) of the participants lived with both parents. Further, the study used an integrating inductive and deductive data analysis techniques, and identified three major themes; Menstrual experiences during menarche, Menstrual experience at present, and Menstrual management practices. Generally, the menstrual experiences of tertiary students were characterized with severe cramps, discomfort, and nausea leading to missed lectures and challenges in maintaining focus during classes. The findings project the need for tailored support systems and educational interventions in tertiary institutions, recognizing the diversity of experiences among female students.
Preserved Benefits and Barriers of Breast Self-examination and Mammography for Breast Cancer Screening in the PERSIAN Guilan Cohort Study (PGCS) population
Authors: Joukar Farahnaz , Zakaryapour Sara , Fashkhami Faezeh , Sheida Fateme , Atrkar-Roshan Zahra , Hasavari Farideh , Mansour-Ghanaei Fariborz 
Published: April 2024

Abstract

Background:Clinical breast examination and mammography help in the detection of breast cancer and are valid in improving survival by reducing mortality. In this study, we aimed to investigate women's knowledge of breast cancer screening in the Prospective Epidemiological Research Studies (PERSIAN) Guilan Cohort study (PGCS) population.Methods:This cross-sectional study was conducted on 476 women aged 35 to 70 among the PGCS population. The demographic and clinical data of participants were collected through a questionnaire. Also, the Champion Health Belief Model, including the perceived benefits of breast self-examination (6 phrases), perceived barriers to breast self-examination (9 phrases), perceived benefits of mammography (6 phrases), perceived barriers mammography (9 phrases), was used to collect the knowledge data. The variables of the questionnaire were assessed using the Likert scale. Data was analyzed using SPSS version 20 by significant level <0.05.Results: Most of the research subjects were within the age of 45-55 years (35.9%) and most of them (64.9%) did not mention any history of prior mammography, but among those whith positive hisstory of mammography, most of them (55.1%) had done it without any problem and only based on recommendation. 83% of the participants reported negative previous history of breast abnormalities or discomfort, while the remaining individuals reported experiencing these issues at least once, of which, 15.5% received medical care, with the most common complication being the experience of breast pain (7.7%). In overall, factors including age 35-44.9 years, having insurance, higher education levels, having former visit of a doctor due to breast problem, family history of breast cacner in first degree relatives, and positive history of performing mammography were associated with better scores of preserved benefits and barriers in both breast cancer self-examination and mammography (P≤0.05).Conclusion:Therefore, according to the barriers and benefits identified in this study, it is possible to plan for breast cancer screening. It is recommended to focus more on attracting older women to perform screening programs. It is also necessary to encourage doctors to refer women for mammography and support insurance organizations to provide screening services at a lower cost.
Surgical Anatomy of Non-Recurrent Inferior Laryngeal Nerves Observed Between 2011–2023
Authors: Sato Koki , Sugino Keizo , Nishihara Masahiro , Kawasaki Yukari , Nambu Junko , Kawaguchi Yasuo , Ohdan Hideki 
Published: April 2024

Abstract
Purpose:
To avoid complications during thyroid surgery, it is important to be aware of anatomical variations. This study aimed to analyze the clinical aspects of non-recurrent inferior laryngeal nerves (NRILNs) at a hospital in Japan.
Methods:
We retrospectively analyzed thyroid surgery cases at our institution over the last 12 years (2011–2023). The study included 2187 patients (1676 women, 76.6%) who underwent total thyroidectomy (TT; N = 512) or hemithyroidectomy (HT; N = 1611). The HT group included 850 right and 761 left thyroidectomies, and 82 patients underwent complementary TTs (40 right and 42 left). The total number of inferior laryngeal nerves identified during surgery was 2717 (1402 right and 1315 left). All patients underwent preoperative neck and thoracic computed tomography (CT) and neck ultrasonography (US). NRILN is classified into two types: Type 1, in which the NRILN branches at the level of the inferior thyroid artery and ascends along the trachea; and Type 2, in which the NRILN branches at the level of the superior pole of the thyroid gland and runs directly to the larynx.
Results:
We identified 12 NRILN cases. The nerve anomaly was diagnosed preoperatively in all patients. Of these cases, eight were Type 1 and four were Type 2. No inferior laryngeal nerve injury was observed after surgery.
Conclusion:
To avoid inferior laryngeal nerve injury, preoperative diagnosis of NRILNs is essential. NRILN is associated with an aberrant right subclavian artery; hence, its presence should be evaluated using routine US and CT before surgery.
Research on full-chain anomaly causal tracing based on S-GAN combined with Bayesian inference
Authors: LIU Lijun , Zhaojun WANG , LI Xiao , Peng WANG , Hongxia GUO , Yanjie DAI 
Published: April 2024

Abstract
The wide coverage of electricity information collection, involving multiple links, strong equipment associations, and a large overall architecture, makes operation and maintenance work complex and difficult to handle. The current monitoring status cannot guarantee the normal operation of each link. Therefore, a method for full-chain monitoring and anomaly tracing of electricity information collection is proposed. Firstly, a full-chain monitoring model for electricity information collection is constructed based on graph neural networks, abstracting the data flow in each link as nodes and the data transmission links as edges to build a graph structure for the entire electricity information collection chain. The abnormal judgment of data flow in various collection businesses is treated as a classification task, and the Graph Attention Network (GAN) is used to explore the features of abnormal data flow in the entire chain of electricity information collection, thereby identifying the nodes with abnormal data flow in the chain. Secondly, causal association rules combined with Bayesian network graphs are used for the causal tracing of abnormal nodes, leading to the identification of the root abnormal node. Experimental results show that the accuracy and F1 value of the abnormal node identification in the monitoring model are 88.17% and 88.25% respectively, achieving effective tracing of the root abnormal node.
Exploring lived experiences on the usage of removable complete dentures among edentulous patients attending Makerere University Dental Hospital, Kampala, Uganda
Authors: Nono David , Bagenda Godfrey , Okullo Isaac , Rwenyonyi Charles Mugisha 
Published: April 2024

Abstract

Background
Edentulism remains a major disability worldwide, especially among the elderly population, although the prevalence of complete edentulism has declined over the last decades. In Uganda, the prevalence of edentulism in people aged 20 years and above is 1.8%. The therapy for edentulous patients can be realized through the use of conventional removable complete dentures, implant-supported prostheses, and computer-aided design and computer-aided manufacturing (CADCAM), however, the provision of removable complete dentures continues to be the predominant rehabilitation for edentulous patients. However, no published study has explored the lived experiences with removable complete dentures among the Ugandan population. The aim of the present study was to explore patients’ lived experiences on the usage of removable complete dentures among Ugandan edentulous patients attending Makerere University Dental Hospital.
Methods
This was a cross-sectional study employing a qualitative approach using purposive sampling. Fifteen (15) respondents were selected across social demographics. Interviews were recorded and transcribed and themes were generated to draw a deeper meaning to the usage of removable complete dentures. A qualitative statistical package, Atlas Ti software was used to generate themes from the interviews followed by an interpretation of the generated data and the results were presented as text and in a table.
Results
The reported key positive experiences due to removable complete denture rehabilitation were the improvement in speech, eating ability, regaining good facial appearance, better oral hygiene management, self-esteem and confidence to smile in public, and a feeling of completeness. However, respondents complained of pain and discomfort due to the looseness of dentures, inability to eat certain foods, and regular cleaning of dentures. The respondents did not go through proper informed consent processes before getting removable complete dentures.
Conclusion
The study found that patients were experiencing both physical and emotional challenges with being edentulous and therefore, opted for denture rehabilitation as a way of getting a credible alternative to their edentulous situation. Therefore, patients should be given quality oral healthcare that is accessible, acceptable, and cost-friendly.
Enucleation for Intestinal Duplications: a Comparative Study With Intestinal Resection and Anastomosis
Authors: Laplanche Ulysse , Montalva Louise , Dara Pichvichit , Coulomb Aurore , Hervieux Erik , Honnla Runreasey , Irtan Sabine , Audry Georges 
Published: April 2024

Abstract
Purpose :
Duplication enucleation (DE) has been described as an alternative to intestinal resection with primary anastomosis (IRA) for intestinal duplications, but no comparative study exists. The aim of this study was to compare both surgical procedures for intestinal duplication.
Methods:
A retrospective study was performed, including all children treated for intestinal duplication (2005–2023). Patients that underwent DE were compared to those that underwent IRA. Statistical significance was determined using p < 0.05. Ethical approval was obtained.
Results:
A total of 51 patients (median age: 5 months) were treated for intestinal duplication, including 27 patients (53%) that underwent DE and 24 IRA (47%). A cystic image was detected prenatally in 19 patients (70%) with DE and 11 patients (46%) with IRA (p = 0.09). Enucleation was performed using laparoscopy in 7 patients (14%). Patients that underwent DE had shorter time to first feed (1 vs 3 days,p = 0.0001) and length of stay (4 vs 6 days, p < 0.0004) compared to IRA. A muscular layer was identified in 68% of intestinal resection specimens.
Conclusion:
Compared to intestinal resection with anastomosis, duplication enucleation is associated with decreased postoperative length of stay and delay to first feeds without increasing post-operative complications. Regarding histological analysis, enucleation seems feasible in most cases.