bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypericin-loaded in modified theranostic liposomes nanoplatform: a preliminary in vivo study of targeting and diagnosis
Authors: de Morais Flávia Amanda Pedroso , Balbinot Rodolfo Bento , Bakoshi Amanda Beatriz Kawano , Lararin-Bidoia Danielle , Campanholi Katieli da Silva Souza , Junior Ranulfo Combuca da Silva , de França Bruna Martins , Gonçalves Renato Sonchini , Ueda-Nakamura Tânia , Silva Sueli de Oliveira , Caetano Wilker , Nakamura Celso Vataru 
Published: March 2024

Abstract

Modified theranostic liposomes was created by combining phospholipid 1,2-dipalmitoyl-sn-3-glycerol-phosphatidylcholine with two previously modified Pluronic® copolymers covalently linked with spermine and folic acid to carry and stabilize the photosensitizer compound hypericin. After physicochemical characterization, the photocytotoxicity was evaluated against different cancer and healthy cells presenting a strong photodynamic effect. The formulation exhibited no photoactivity without illumination and without hypericin. In vivo pharmacokinetics biodistribution examined the uptake and theranostic potential of this nanoformulation after its intravenous administration in animal models. Fluorescence images revealed the maximum fluorescence between 0.5-4 h post-tail vein injection, making it an appropriate period for photodynamic treatment. The fluorescence of the entire body was monitored for at least 3-days, indicating that the theranostic procedures can be performed within the 0.5-4 h range after administration, after which the intensity decreases, indicating a potent metabolic ability with no significant side effects. The fluorescence images of the main organs consistently showed a signal during the 1st day of its application. After 48 h, only residues of the modified theranostic formulation were detected in the lungs and thyroid. The promising pharmacokinetics observed in our preliminary studies highlight the potential of this system, making it a worthy candidate for further investigation with tumor models.
Minibleph, A Non-Incisional Blepharoplasty Technique For Skin Tightening Of Eyelids With The Use Of Fractional CO2 Laser
Authors: Amesty María Alejandra , Medalle Ronald Steven II , Beckers Lena , Cantó-Cerdán Mario , Barrio Jorge L. Alió del 
Published: March 2024

Abstract

Purpose
To measure the efficacy of “Minibleph,” a minimally invasive, non-incisional technique that utilizes a fractional CO2 laser for periocular rejuvenation.
Methods
3-month case series of 22 eyes with eyelid skin laxity, periocular wrinkles and dermatochalasis treated with a CO2 laser with a fractional ablative resurfacing scanner. Included data were pre/post procedure ocular skin laxity, texture and pigmentation, lid measurements, dermatochalasis grade and satisfaction questionnaires.
Results
At 3 months post-treatment, all patients had improved skin laxity and texture where 54.5% of eyelids were in the 4th quartile (75–100% improvement). No signs of postreatment hyperpigmentation. Moreover, there was significant improvement in Eyelid Fold (p-value 0.048), MRD1 (p-value 0.008) and Palpebral Fissure (p-value 0.008) values. There was significant improvement of dermatochalasis (p-value 0.034) where 11 eyelids (50%) improved in dermatochalasis grade. FACE-Q questionnaire showed significant decrease of Upper/ Lower Eyelid Rasch scores (p-value 0.03). Recovery Early Symptoms mean value was low (25.55/100), while means of the Satisfaction with Outcome was high (78.82/100).
Conclusion
“Minibleph” is a safe technique for periocular rejuvenation, improving skin laxity, texture and wrinkles. It may also improve mild dermatochalasis and palpebral fissure opening, However, it is not suitable for correcting moderate to severe dermatochalasis that requires surgical intervention.
Exploring the Path of Green Innovation and High Quality Development of Influential Regional Enterprises - Based on the Analysis of Dynamic QCA Method and Matlab Sustainability Prediction
Authors: LIU QIJAI 
Published: March 2024

Abstract

Objective: To study the multifactor linkage effects behind the differences in the sustainable development of green innovation of local enterprises in the spatio-temporal dimension, so as to provide an important reference for the practice of sustainable development of green innovation of local enterprises.
Methodology: An analytical framework for the sustainable development of green innovation of local enterprises is established, and the dynamic QCA method is applied to analyse the provincial-level panel data of China from 2012 to 2021, to explore the linkage effect of each factor on the time axis, and to explore the differences of multi-factors on the time axis. The experimental study also examined the spatial distribution of regional coverage in conjunction with different regional divisions in China.
Findings The study found that different factors may have different influence effects in different contexts. Firstly, while market demand is an important influencing factor, its role relative to economic drivers and social environment factors may be relatively limited in some contexts. Second, high levels of foreign investment and demand for innovation in the service sector have a significant impact on green innovation in local firms. At the same time, with the growing consumer preference for green products, green preferences in market demand have also begun to become an important factor influencing firms' green innovation. Meanwhile, in the spatial dimension, the provincial coverage out of the obvious regional differences.
Experimental significance The research on the sustainable development of green innovation of local enterprises needs to be combined with the actual situation in China, and the resource differences and characteristics of different regions make it necessary for local enterprises to combine with their own reality in the process of green innovation to achieve the linkage and complementarity of factors. This requires local governments to fully consider the actual situation of the region when formulating relevant policies, and promote green innovation according to local conditions. This experiment is the first attempt to use the joint application of dynamic QCA and Matlab for the study of green innovation in local enterprises, exploring the consistency in the longitudinal time dimension.
Electroacupuncture Treatment for Sarcopenia: Study Protocol for a Randomized Controlled Trial
Authors: Li Hao , Zhou Li , Zhang Xin , Wen Qian , Tian Li , Yang Han , Chen Xirong , Yuan Jinghan , Li Ning , Zhu Bingmei , Zhang Lin , Lu Lingyun 
Published: March 2024

Abstract
Introduction: Sarcopenia is a disease primarily characterized by age-related loss of skeletal muscle mass, muscle strength, and/or decline in physical performance. Sarcopenia has an insidious onset which can cause functional impairment in the body and increase the risk of falls and disability in the elderly. It significantly increases the likelihood of fractures and mortality, severely impairing the quality of life and health of the elderly people. This disease poses a heavy burden on the healthcare system and society in our country, and currently, there are limited clinical intervention strategies for sarcopenia. This study aims to explore the clinical efficacy and safety of electroacupuncture in treating sarcopenia.
Methods and Analysis: In this parallel-design, randomized, sham-controlled trial, a total of 168 elderly sarcopenia patients will be randomly assigned in a 1:1 ratio to receive either electroacupuncture (EA) or sham electroacupuncture (sEA) treatment. The acupuncture points used in the study are Hegu (LI4), Shousanli (LI10), Quchi (LI11), Binao (LI14), Futu (ST32), Liangqiu (ST34), Zusanli (ST36), and Jiexi (ST41). The participants will receive EA or sEA treatment three times per week for eight weeks. The primary outcome measure is the change in grip strength (GS) of the patients after the eight-week treatment. The secondary outcome measures include the changes in grip strength at the fourth and twentieth weeks, changes in appendicular skeletal muscle mass index (ASMI), the Short Physical Performance Battery (SPPB) score, the physical activity level (PAL) assessed by the International Physical Activity Questionnaire (IPAQ), assessment of expectations regarding the efficacy of acupuncture, patient subjective evaluation of efficacy, and evaluation of blinding efficacy of acupuncture. All statistical analyses will be conducted according to the intention-to-treat principle and as per the study protocol.
Ethics and Dissemination: This study protocol was reviewed and approved by the Institutional Review Board of West China Hospital of Sichuan University (permission number: 2023-525). The participants will provide written informed consent to participate in this study.
Trial Registration: Chinese Clinical Trial Registry (http://www.chictr.org.cn), ChiCTR2300079294.
Factors that influence osteoarthritis in the medial compartment of the patellofemoral joint
Authors: Li Min , Kang Huijun , Chang Bo , Wang Xiaomeng , Li Zhao , Kong Lingce , Xing Enzeng , Wang Fei 
Published: March 2024

Abstract
Background
The incidence of medial patellofemoral articular cartilage injuries was significantly higher than that of the lateral, although many studies have suggested that lateral patellofemoral intercompartmental pressure is higher than that of the medial. The mechanism of medial patellofemoral cartilage injury remains unknown. The objective of this investigation is to explore the factors that may influence the development of medial compartment osteoarthritis in the patellofemoral joint.
Methods
This study included imaging of 246 knees from 235 patients. These patients were divided into medial more severe patellofemoral compartment osteoarthritis group(MPFOA), lateral more severe patellofemoral compartment osteoarthritis group(LPFOA) by the Whole-Organ Magnetic Resonance Imaging Score (WORMS). The development of MPFOA or LPFOA was analyzed by logistic regression equations about these factors: hip-knee-ankle angle (HKA), Suleus angle (SA), Congruence angle (CA), Lateral Patellofemoral angle (LPTA), Patellar Tilt angle (PTA), Patellofemoral index (PFI), Insall-Salvati index (I-S), Femorotibial rotation angle (FTR), Tibial tubercle-trochlear groove distance (TT-TG), Patella Wiberg type, Dejour classification of femoral trochlea, and Kellgren-Lawrence (K-L) grade.
Results
123 cases had a more severe osteoarthritis in the medial patellofemoral compartment compared to the other 123 cases. The results of binomial multivariate logistic regression analysis showed that having a Wiberg type I patella (OR = 4.364, 95%CI:1.910 ~ 9.969, P = 0.000), and having a FTR > 10° (OR = 3.497, 95%CI:1.370 ~ 8.926, P = 0.009) were high-risk factors for MPFOA. 70 cases had a more severe osteoarthritis in the lateral patellofemoral compartment compared to 176 other cases. The results of binomial multivariate logistic regression analysis showed that having a Wiberg type III patella (OR = 2.916, 95%CI: 1.267 ~ 6.712, P = 0.012), and having a FTR < 0° (OR = 4.601, 95%CI: 1.416 ~ 14.946, P = 0.011) were all high-risk factors for LPFOA.
Conclusions
FTR angle and patellar Wiberg type have a strong influence on the severity and incidence of medial and lateral osteoarthritis of the patellofemoral joint. The prevalence of MPFOA may not be related to varus and vaglus of the lower limb. The dynamic factors of the weight-bearing position of the patellofemoral joint are important when studying the pathogenesis of medial patellofemoral osteoarthritis.
Intertextuality as a social and discursive process: an analysis of Editorial Notes
Authors: Juanzo Carlo Joseph 
Published: March 2024

Abstract
It is surmised that an utterance can never be original (Liddicoat, et al., 2008) because it always refers to the past, extends to the future and relates other semantic processes (Lemke, 2002, 2009). The present study explores the intertextuality embodied in a widely-circulated magazine (Reader’s Digest), and from the data of 36 editorial notes (EN’s) published from 2008–2010, it was found that EN’s are a social-discursive instrument fulfilling the intertextual functions of the editors which further adhere to actional and heteroglossic intertextualities. After a thorough discussion, a framework of intertextuality-based analysis on EN’s and possibly, of all other discourses, is postulated.
Effect of alginate oligosaccharide on the efficiency of wastewater purification in ecological floating bed aquaculture
Authors: Xu Xueren , Li Jun , Li Cong , Wang Feng , Zhou Sheng 
Published: March 2024

Abstract
In order to investigate the effect of alginate oligosaccharide (AOS) on the water purification efficiency of an ecological floating bed system used in aquaculture, water spinach was cultivated in aquaculture wastewater treated with varying concentrations of AOS (0.025, 0.05, 0.1, and 0.2 mg/L), with an ecological floating bed without AOS serving as the control group. Experimental results reveal that the addition of an appropriate amount of AOS to the wastewater in the ecological floating bed system promotes the growth of water spinach. This is evident in the increased plant height, stem diameter, main root length, number of roots, leaf area, aboveground fresh weight, belowground fresh weight, aboveground dry weight, belowground dry weight, seedling index, chlorophyll a, chlorophyll b, and chlorophyll content. The combination of 0.05 mg/L AOS with the ecological floating bed exhibits the most favorable results, with percentage increases in various indicators were 44.0%, 52.9%, 29.9%, 62.0%, 28.0%, 141.6%, 84.0%, 97.7%, 220.0%, 24.6%, 34.2%, 26.9% compared to the control group. The addition of AOS to the water spinach ecological floating bed system significantly enhances the removal efficiency of water turbidity, chemical oxygen demand (COD), ammonia nitrogen (NH4+-N), nitrate nitrogen (NO3−-N), total nitrogen (TN), and total phosphorus (TP) water quality indicators. The combination of 0.05 mg/L AOS with the ecological floating bed demonstrates the optimal removal efficiency. This experiment also investigated the differences in microbial community structure between the control group and the group with the optimal concentration of AOS to study the mechanism of action of AOS. This study offers crucial technical insights for further optimizing ecological floating bed technology and improving water purification efficiency.
Effects of Ultrasound Cycloplasty in Glaucoma Patients:6-Month Results From a Prospective Clinical Study
Authors: Li Liu , Li Ying-Jie , Hong Ling , Wang Yong-Bo , Zhu Xuan 
Published: March 2024

Abstract

Objectives
To explore effects of ultrasound cycloplasty (UCP) in glaucoma patients, aiming to evaluate the efficacy and safety of UCP.
Methods
Twenty-two glaucoma patients (23 eyes) who received UCP treatment at the Ophthalmology Department of Nanchang First Hospital from July 2020 to September 2022 were selected.Intraocular pressure (IOP), number of anti-glaucoma agents, best corrected visual acuity (BCVA) and eye pain scores of the patients before and 1, 3, 7 days, 1, 3 and 6 months after treatment were recorded.The complications during treatment and after treatment were also observed.The corneal curvature, pupil size, corneal thickness and anterior chamber depth of pentacam before and 1 day, 1 and 6 months after treatment were measured.
Results
The preoperative IOP, number of anti-glaucoma agents, and eye pain scores were 37.35 ± 13.79 mmHg, average 3.35 ± 1.23 and 4.39 ± 2.15, which were decreased significantly at each time point after UCP treatment (P < 0. 01). The IOP decrease rates were 33.31%, 45.68%, 46.32%, 47.23%, 41.93%, and 48.46%, respectively. The postoperative IOP reduction at 1, 3 and 7 days, 1, 3 and 6 months were significantly correlated with preoperative IOP (r = 0.719, 0.750, 0.797, 0.661,0.515 and 0.607, all P < 0.05). No serious complication was observed throughout the treatment and the follow-up.There was a temporary change in anterior keratometry 1 day after UCP treatment. BCVA, pupil diameter, corneal thickness and anterior chamber depth remained unchanged.
Conclusion
UCP was demonstrated to be effective in decreasing IOP, IOP-lowering medications and pain scores in patients with glaucoma. It’s well-tolerated without intraoperative or postoperative complications.
Pilot study of the role of ferroptosis in abnormal biological behaviour of keratinocytes in psoriasis vulgaris
Authors: Wu Ningling , Hu Qian , zhou Lu , Fu Zhibing , Tong Xiaoliang , Gao Lihua , Tan Lina , Yan Siyu , Wang Dan , Zeng Jinrong , Lu Jianyun 
Published: March 2024

Abstract
Background
Abnormal biological behaviour of keratinocytes (KCs) is a critical pathophysiological manifestation of psoriasis. Ferroptosis is programmed cell death induced by the accumulation of lipid reactive oxygen species (ROS) in the presence of increased intracellular iron ions or inhibition of GPX4.
Objectives
The purpose of this study was to investigate the effects of ferroptosis on the biological behaviour of KCs in psoriasis vulgaris and its possible regulatory mechanisms in clinical samples, cells, and mouse models.
Methods
We first examined the differences in the expression of GPX4 and 4-HNE between psoriasis and normal human lesions. And detected KRT6, FLG, and inflammatory cytokines after inducing ferroptosis in animal and cell models by RT-qPCR, Western blot, immunohistochemistry, and flow cytometry.
Results
We found that GPX4 was decreased and that the oxidation product 4-hydroxy-2-nonenal (HNE) was increased in the skin lesions of patients with psoriasis vulgaris. The expression level of GPX4 correlates with the severity of skin lesions. Moreover, inducing ferroptosis promoted the expression of FLG and reduced the expression of KRT6 and inflammatory cytokines in vitro, and alleviated the phenotype of skin lesions in vivo.
Conclusions
This study confirms the existence of ferroptosis in psoriatic lesions, which may be inversely correlated with disease severity. The ferroptosis inducer RSL3 ameliorated psoriatic symptoms by improving the abnormal biological behaviour of KCs.
Mites associated with açaí palm trees (Euterpe oleracea: Arecaceae) in native and cultivated areas of the state of Pará, eastern Amazon, Brazil
Authors: BRITO EDNA ANTÔNIA DA SILVA , CASTRO IURY SILVA , NORONHA ALOYSÉIA CRISTINA SILVA , FERLA NOELI JUAREZ 
Published: March 2024

Abstract
The objective was to quantify and analyse the diversity of mites associated with native and cultivated açaí palms crops, as well as their distribution in the dry and rainy seasons in the municipalities of Bragança and Augusto Corrêa, state of Pará. Rarefaction curves were generated for diversity values using the statistical programming language R, rarefaction curves for estimates of richness and equitability and analysis of variance with permutations. A total of 2,069 mites from 28 families were sampled, being most representative Phytoseiidae (32.4%), Phytoptidae (13%), Cunaxidae (7.7%), Tetranychidae (5.6%) and Tydeidae (4.9%). Among predators, the most abundant species were Amblyseius sp. 1, Armascirus amazoniensis Wurlitzer & Silva, Iphiseiodes zuluagai Denmark & Muma, Scutopalus tomentosus Rocha, Skvarla & Ferla, and the phytophagous mites Acaphyllisa sp., Davisella sp., Oligonychus sp. and Retracus johnstoni Keifer. In the rainy season, more mites were sampled (n = 1,176) than in the dry season (n = 893). The greatest richness was observed in the dry period (73 species) and diversity was also greater in this period. In the municipality of Bragança there was greater richness (78 species) and the cultivated açaí trees had greater acarine abundance (74.7%) than the native ones. However, natives had slightly higher wealth (6%) than those cultivated. The diversity and richness of predatory mites show the potential of the Amazon biome to be used in applied biological control.
A DEA-WEI Cross-Efficiency Approach for Ranking Universities in the Presence of Imprecise Data
Authors: Luckhoo Bibi Faheema , Peer Arshad Ahmud Iqbal 
Published: March 2024

Abstract
Recently, the popularity of university rankings has grown significantly. They are considered a significant source of guidance for various stakeholders.Some of the most well-known rankings are the Academic Ranking of World Universities (ARWU), Quacquarelli Symonds World University Rankings (QS), and Times Higher Education Rankings (THE). These ranking systems usedifferent parameters and methodologies, producing different ranking results.Here, we use data envelopment analysis (DEA) to obtain anaggregate ranking of universities based on the data of these established systems.Because of DEA's lack of discriminatory power, we considered the cross-efficiency method, which allows ordering among entities and removes unrealistic weight schemes without weight restrictions.Cross-efficiency evaluation is usually applied only to precise inputs and outputs.Since our data set does not include any input measures, DEA-WEI (Without Explicit Input) modelsare studied. To consolidate the classification, we consider the rankings of thethree systems, which are ordinal data. Hence, we develop a new cross-efficiency approach torank entities with imprecise data and WEI. In order to illustrate the applicability of our proposed model, we apply it to the rankings data and institutes of the Chinese Academy of Sciences.
MSC Classification: 90C08 , 90C90
Impact of inorganic hybrid nanofiller on structural, optical, thermal and dielectric properties polymer nanocomposites for optoelectronic devices
Authors: M Gayitri H , Al-Gunaid Murad Q. A. 
Published: March 2024

Abstract
Nanocomposite (NC) films of poly vinyl alcohol (PVA) incorporated with varying amounts of Calcium Cadmium doped Aluminum oxide (CaCdAl2O5) nanoparticles (NPs) have been fabricated by solution intercalation technique. TEM result showed the size of NPs between 8-34nm. The effects of NPs content on structural and morphological behaviors of PVA have been established by XRD, FTIR and SEM techniques. Electrical properties of NC films were performed using LCR-meter. Current (I)-voltage (V) data displayed dc-conductivity increased with increasing NPs content and trends of I–V indicate the dominant Ohmic behavior at voltage <5V and above that Poole–Frenkel emission is the dominant conduction mechanism. Ac-conductivity increases with increase in frequency and dosage of NPs. The maximum ac-conductivity obtained in this investigation is 2.43x10-5 S/cm for PVA/8wt% CaCdAl2O5. The reduction in Tg with increment NPs contents was observed. The optical behaviors of NCs were deduced by UV visible spectroscopy where the result showed band gap energy was reduced from 5.23eV to 3.25eV whereas refractive index increased from 1.71 to 2.44 for pure PVA and PVA/8wt% CaCdAl2O5, respectively.