bluuebunny/crossref_metadata_2025_split huggingface dataset:
Malignant melanoma of the upper extremities
Authors: Ariel Irving M. 
Published: February 2007

AbstractThere were 487 patients treated for malignant melanoma of the upper extremities at the Pack Medical Group in New York City between 1939 and 1967 inclusive, fourth in frequency (14.7%) of total malignant melanomas treated here, being exceeded by malignant melanoma of the trunk (34%), head and neck (23%), and the lower extremities (20%). A 10‐year survival rate of 342 determinate patients was 63%. Fourteen percent of the patients who died of melanoma died between the fifth and tenth years, indicating the need to report survival at the 10‐year span. Survival was equal for the sexes (61% male and 64% female). The majority of the patients had infiltrating melanomas (Clark's Level 4 and 5) with a survival rate of 62%. Ten patients with superficial spreading melanomas (Clark's Level 2 and 3) and juvenile melanomas enjoyed a 100% 10‐year survival. The worst prognosis was for six patients with amelanotic melanoma in that only two of ten survived ten years or longer. The question of elective axillary dissection remains elusive. In 106 patients classified as clinical Stage I, elective axillary dissection was performed in 55 instances, and 26 patients had microscopic evidence of metastases. Their 10‐year survival rate was 65%, slightly higher than 16 patients in whom no elective axillary dissection was performed, among whom six later developed evidence of metastases, underwent therapeutic node dissections, and had a 10‐year survival of 56%. Radical amputation is occasionally indicated with great palliation and often prolongation of life.
Leiomyosarcoma of the adrenal gland and its angiographic features: A case report
Authors: Choi Sung H. , Liu Kuochin 
Published: February 2007

AbstractA case of leiomyosarcoma of the adrenal gland is reported. This is a rare neoplasm at this location and actually may arise from the venous wall of the gland. Angiographically, this lesion is demonstrated as a vascular mass with early draining of the vein.
Side effects to levamisole given to neoplastic patients as adjuvant to surgery: A new case of agranulocytosis
Authors: Colizza S. , Bagolan P. , Paola M. Di 
Published: February 2007

AbstractSide‐effects to levamisole given as adjuvant to surgery in a consecutive series of 203 neoplastic patients are reported: Thirty‐four patients (16.7%) suffered gastric adverse reactions; 8 (3.9%) allergic; 6 (2.9%) intestinal; 6 (2.9% neurologic; 4 (1.9%) severe hyperthermia (more than 40.5°C); 3 (1.4%) flu‐like illness; 1 (0.4%) leucopenia; and 1 (0.4%) agranulocytosis. Withdrawal rate was 5.4% or 11 patients. Side effects appeared sex‐related (39.0% in females, 17.7% in males; with seven female dropouts out of 11), unrelated to other eventual adjuvant treatments, and reappearing at a new challenge with levamisole. The opportunity of very close control of patients taking levamisole for at least the first months is discussed.
Intracavitary bleomycin for the control of malignant effusions
Authors: Bitran Jacob D. , Brown Charles , Desser Richard K. , Kozloff Mark F. , Shapiro Charles , Billings Arthur A. 
Published: February 2007

AbstractThe results of treatment with intracavitary bleomycin are reported in twenty patients with a malignant pleural effusion and five patients with malignant ascites. The control rate was 17/20 (85%) patients with malignant pleural effusions and 3/5 (60%) patients with malignant ascites. Toxicities were minimal with fever being the most common side effect in four patients (16%). Bleomycin is an effective and nontoxic sclerosing agent.
Complications from staging laparotomy for hodgkin disease
Authors: Kaiser C. William 
Published: February 2007

AbstractNonspecific complications from staging laparotomy are usually related to general anesthesia or abdominal exploration. Specific complications for the procedure do exist: intubation difficulties during administration of anesthesia to patients with untreated mediastinal disease, sepsis in up to 20% of patients, depending on stage of disease and intensity of postoperative chemotherapy and radiotherapy, arterial and possibly venous thromboemboli from extensive retroperitoneal node dissection, pancreatitis, small bowel obstruction from adhesions to node biopsy sites, operative mishaps, subphrenic abscesses, and bleeding from liver biopsies. Certain patient subpopulations are at especially high risk for some of these complications and their identification and possible measures to minimize such problems are proposed.
Herpes simplex type 2 neutralization antibodies in patients with cancers of urinary bladder, prostate, and cervix
Authors: Lüleci Güven , Sakizli Meral , Günalp Altan , Erkan Ilhan , Remzi Dogan 
Published: February 2007

AbstractIn the blood samples obtained from a total of 68 patients with cancers of the urinary bladder, prostate, and cervix, who applied to the Departments of Urology, Obstetrics, and Gynecology of Hacettepe Medical Faculty, neutralizing antibodies were sought for against herpes simplex type 2 by neutralization test. The same test was applied to 35 control patients with no known malignancies. In contrast to the presence of the antibody in 62.86% of the control subjects, this ratio was 90.70% in patients with cancer of the urinary bladder, 87.50% in those with prostatic carcinoma, and 88.89% in those with cancer of the cervix.
Adrenal adenocarcinomas: Diagnosis and management
Authors: Karakousis C. P. , Uribe J. , Moore R. 
Published: February 2007

AbstractThirty‐two patients with adrenal adenocarcinoma are reviewed. Eleven of them had symptoms suggestive of a hormonally functional tumor. The median survival in 17 patients who had the primary tumor removed was 13.5 months from the time of surgery, with one patient surviving disease‐free 19 years later. The median survival of 11 patients who did not have surgery owing to delays in diagnosis was 7.5 months from the onset of symptoms. Of six patients given O, P'DDD, two patients had objective regression, one partial, one complete. Early diagnosis may improve survival and curability of this malignant tumor.
Parenteral hyperalimentation in surgical patients with head and neck cancer: A randomized study
Authors: Sako Kumao , Loré John M. , Kaufman Sol , Razack Mohamed S. , Bakamjian Vahram , Reese Peter 
Published: February 2007

AbstractSixty‐nine patients were entered in a randomized study to determine the usefulness and practicality of parenteral hyperalimentation (TPN) in preparing and supporting patients with head and neck cancer undergoing radical resections.The patients were stratified by nutritional status and prognosis and randomization were done within each strata to TPN or control. Minimum full TPN was given at 35 calories/kgm/day for at least 14 days postoperatively. Eight patients received preoperative TPN also. Control patients received customary enteral alimentation by feeding tubes. Under the conditions of this particular study, the administration schedules, and type of solutions used, we were unable to demonstrate any superiority of TPN over conventional enteral nutrition in terms of immune parameters, wound healing, complications, and survival.
Surgical treatment of metastatic disease in the thyroid gland
Authors: Ericsson Mats , Biörklund Ander , Cederquist Ebbe , Ingemansson Stig , Åkerman Måns 
Published: February 2007

AbstractMetastatic disease in the thyroid gland is uncommon in clinical practice. Preoperative investigation with thyroid scan and fine‐needle aspiration biopsy verified or strongly suggested metastatic disease in seven out of nine patients. All patients were treated by thyroid surgery. Three patients died within 4 months in disseminated disease. The remaining seven patients had a survival rate of between 1 and 5 years. Three patients are still alive 12, 29, and 48 months after thyroid surgery. Surgical treatment for metastatic disease in the thyroid, especially due to metastatic renal carcinoma and melanoma, is recommended.
Malignant tumors of the nasopharynx
Authors: Baker Shan Ray 
Published: February 2007

AbstractOne hundred and twenty patients with malignancy of the nasopharynx were reviewed. The most common presenting symptoms of this disease were cervical mass and hearing loss. Neoplasm occurred three times more frequently in males than in females. Cranial nerve dysfunction was present in 17.5% of patients at the time of initial evaluation.The overall 3‐ and 5‐year determinate survival for the entire series of nasopharyngeal malignancies was 38.9, and 27.0%, respectively. Nonsquamous cell malignancies demonstrated a better 5‐year survival (42%) than squamous cell and undifferentiated neoplasms (24%).The presence of cervical metastases offered a poorer prognosis. A 39.6% 5‐year survival was recorded for patients without nodal disease. Massive lymphadenopathy or bilateral cervical metastases forecasted an ominous 5‐year survival of 13.6%.Control rate was greatest among patients with tumors restricted to one area of the nasopharynx and without regional metastases. The 5‐year survival of such patients was 71.4% compared to 13.3% for patients having tumor extension beyond the nasopharynx producing cranial nerve impairment or bone erosion.
Ovarian metastases from colon carcinoma
Authors: Mason Miles H. , Kovalcik Paul J. 
Published: February 2007

AbstractA case report describes a postmenopausal woman who presented with vaginal bleeding and a pelvic mass. She was found to have a colon cancer with a large metastasis in the right ovary. A review of the literature suggests that ovarian metastasis from a primary colon carcinoma is not rare. Frequently, the ovarian tumor causes symptoms sooner than the primary carcinoma. The presence of ovarian metastasis is associated with a poor prognosis. Consideration should be given to the performance of prophylactic oophorectomy during colon resections for carcinoma.
Tumors of the testis in two brothers: A case report
Authors: Wobbes Th. , Hoekstra H. J. , Sleyfer D. T. H. , Koops H. Schraffordt 
Published: February 2007

AbstractThis paper described two nontwin brothers with a nonseminoma tumor of a testicle: an embryonal carcinoma in one and an embryonal carcinoma with seminomatous components in the other. Testicular tumors of the same type have the same frequency in twin brothers as in nontwin brothers. For the present, there is no insight into the genetic influence in the pathogenesis of testicular tumors.
The protection of small amounts of splenic tissue against intravenous pneumococcal challenge following subtotal splenectomy
Authors: Goldthorn Jane F. , New Bonnie A. , Schwartz Allen D. 
Published: February 2007

AbstractThe asplenic state increases susceptibility to overwhelming bacterial infection. We studied the ability of small amounts of splenic tissue to protect against intravenous pneumococcal challenge following subtotal splenectomy in which approximately 75% of the spleen was removed. Animals that had undergone subtotal splenectomy were more resistant to challenge than were asplenic animals, but were not as resistant as were control animals. The small amount of residual splenic tissue confers some degree of protection against intravenous bacterial challenge.
Malignant tumor emboli to the peripheral vessels
Authors: Vo Nghia M. , Sakurai Hideki , Gambarini Alberto J. 
Published: February 2007

AbstractThe first case of tumor emboli trapped in a popliteal aneurysm and the longest survivor for this condition are reported. The characteristics of 25 cases reported in the literature since 1940 and the mechanism of tumor spread are reviewed. Tumor emboli represent the late stage of a malignancy and treatment does not seem to affect long‐term survival.
Facilitation of cancer metastases by an air pollutant
Authors: Richters Arnis 
Published: February 2007

AbstractAn experimental model was designed to test the possibility that inhalation of a noxious air pollutant may facilitate the blood‐borne cancer cell metastasis to the lungs. Animals were exposed to inhalation of air containing 0.8 ppm of nitrogen dioxide for 12 weeks. After this period, animals were infused intravenously with melanoma cells, and 3 weeks later lungs were examined for metastases. The results indicate that NO2exposed animals develop significantly higher number of lung metastases (P < 0.0025) than the controls. Such results raise the possibility that the inhalation of NO2 from ambient air may facilitate the seeding and proliferation of blood‐borne cancer cells in the human lung.
Management of early glottic cancer
Authors: Jose Baby , Mohammed Alyas , Calhoun David L. , Tobin Daniel A. , Scott Ralph M. 
Published: February 2007

AbstractA detailed retrospective analysis of 136 patients with early glottic cancer treated at the University of Louisville, Radiation Center from October, 1953 to December, 1975 was done. Majority of the patients were in the age range of 55 to 74 years. Of them, 89% were male and 85% were Caucasian. The most common histological type was squamous cell carcinoma. The adjusted 5‐year survival rate was 84%, with a standard error of 3%. Of these patients, 18% had local failures, and 68% of which were salvaged by surgery. The overall local control rate was 93%. The median time to recurrence was 23 months. There was no case of laryngeal necrosis, and a good function of larynx was achieved in a majority of the patients. Eighteen second cancers were diagnosed in 17 patients during the follow‐up. A brief review of the literature is also done in the paper.
Sarcoma of the maxillary sinus in a patient with malignant melanoma: Report of a case
Authors: Kress Donald W. , Miller Stephen H. , Graham William P. 
Published: February 2007

AbstractA patient with a level II malignant melanoma arising in a lentigo maligna later developed a spindle cell sarcoma of the maxillary sinus which proved fatal. Criteria for the reporting of multiple malignancies, incidence, and possible etiologies are discussed.
Comparison of histologic subtypes of multiple biopsies of malignant lymphoma
Authors: Lee Yeu‐tsu N.(Margaret) , Hori Jose M. 
Published: February 2007

AbstractThis is a retrospective study of 163 patients with Hodgkin disease and 364 patients with other lymphomas who were admitted to one Cancer Hospital (1940–1971). All the histological slides were reviewed and reclassified by one pathologist. In patients who had multiple and sequential biopsies (16 with Hodgkin disease and 97 with non‐Hodgkin lymphomas), the histological subtypes remained the same in over 60% of the case. When changes did occur, the neoplasms progressed toward histologically more malignant forms.
Familial bilateral breast cancer
Authors: Al‐Jurf Adel S. , Urdaneta Luis F. , Jochimsen Peter R. , Stamler Frederic W. 
Published: February 2007

AbstractThe occurrence of bilateral breast cancers in three members of one family is reported. In two members, evidence of a distinct primary lesion in each breast was verified. The occurrence of unilateral breast cancer and other cancers in other members of the family was surveyed. Recommendations for early detection and surveillance in familial breast cancer at the present time should be by aggressive and close follow‐up of the affected members. Absence of reliable markers preclude effective surveillance for early detection or susceptibility.
Management of the undescended testis in relation to the development of cancer
Authors: Welvaart K. , Tijssen J. G. P. 
Published: February 2007

AbstractThe undescended testis carries an increased risk of cancer; however, the exact individual risk of a cryptorchist during his life to develop cancer is unknown. The risk of developing cancer can be calculated from three important figures: (a) the number of cryptorchists in the population; (b) the number of malignant testicular tumors found in undescended testicles; and (c) the number of testicular tumors per annum. In the literature, a 48 times increased chance to develop testicular cancer is accepted; it is a high risk which is contrary to the fact that a malignant cryptorchid testis is a very rare disease. Based on the estimated risk for the cryptorchist in the Netherlands to develop testicular cancer, this article criticizes the value of the figures that are generally used to calculate the individual risk; it is concluded that even today the exact risk is unknown. In giving advice concerning the management of undescended testis, one must appreciate not only the supposed cancer risk, but also take into consideration morbidity and mortality after prophylactic orchidectomy and improved cure rates after electively treated testicular tumors.
Serum β2—microglobulin and carcinoembryonic antigen in patients with gastric disorders
Authors: Satake Katsusuke , Kitamura Teruo , Ishikawa Tetsuro , Mukai Ryuichiro , Yoshimoto Takayuki , Chung Yong‐Suk , Umeyama Kaoru 
Published: February 2007

AbstractA comparative study of carcinoembryonic antigen (CEA) and β2‐microglobulin in serum was made by radioimmunoassay in 121 patients with gastric disease. There was no statistical difference in serum CEA and β2‐microglobulin in patients with benign gastric disease, early gastric carcinoma, and advanced gastric carcinoma. However, CEA levels in patients with advanced gastric carcinoma were higher than those in benign gastric disease and in early gastric carcinoma but β2‐microglobulin did not show any differences. Furthermore, after total removal of the tumor, the elevated CEA levels decreased but β2‐microglobulin remained unchanged. We concluded that CEA appeared to predict tumor behavior more accurately in patients with gastric carcinoma than β2‐microglobulin.
Renal cell carcinoma metastatic to skeletal muscle mass: A case report
Authors: Karakousis C. P. , Rao U. , Jennings E. 
Published: February 2007

AbstractAn unusual case of metastases to the right thigh muscles and region of the external iliac vessels is presented. This followed 5 1/2 years following a right nephrectomy for renal cell carcinoma. The patient's metastases were removed and one year later the patient remains free of recurrence.
Human melanoma growth in the peritoneal cavity of the athymic mouse—A model for in vivo study of cell‐mediated immunity
Authors: Akimaru Koho , Stuhlmiller Gary M. , Seigler H. F. 
Published: February 2007

AbstractIntraperitoneal injections of 2 × 107 SH‐Me cells (human metastatic melanoma cells) to 20 Balb/c nu/nu mice (Group A) and 1 × 107 cells to 20 mice (Group B) were performed. All animals were studied clinicopathologically. Five animals in Group A were sacrificed serially, revealing marked tumor growth of the melanoma within the peritoneal cavity. These tumors grew in multiple nodular configurations and tumor ascites was present by the third week. The remaining 15 animals in Group A were allowed to progress and seven subsequently died with mouse viral hepatitis (MVH). These animals had suppressed tumor growth. The remaining eight animals died of peritoneal carcinomatosis with survival time of 24.1 ± 5.0 days. Eight of the animals in Group B died of mouse viral hepatitis while the remainder died of peritoneal tumor without distant metastasis. Survival time in these animals was 23.8 ± 2.6 days. Both 2 × 107 and 1 × 107 tumor cells injected intraperitoneally will constantly produce tumor nodules in non‐MHV‐infected nude mice with similar survival. This experimental model has proven useful for in vivo study to assess the immunoreactivity of melanoma patient cells reactive against target tumor cells.
Pathology of metastasizing tumors in nitrosomethyl urea‐induced rat mammary carcinoma
Authors: Ghosh Luna , Nassauer Joyce , Faiferman Isidore , Ghosh Bimal C. 
Published: February 2007

AbstractThe metastatic capacity of rat mammary tumors induced with N‐nitrosomethyl urea was tested in BUF/N inbred female rats by successive transplantation. After the first and second passage, tumor cells appeared diffusely distributed throughout the bone marrow and spleen, confirming results reported by others; no other metastases were observed. After six successive transplantations, large, well‐defined tumor nodules were observed in the liver, spleen, lung, and the peritoneal surface of the intestines in 40% of the injected animals. The morphology of the primary and metastatic tumors was compared by light microscopy. The tumors appeared to be adenocarcinomas with differing degrees of differentiation. No morphlogical differences could be observed between the primary and the metastatic tumors.
Is gastric cancer generalized at the time of surgery?
Authors: Papachristou Dimitrios N. , Fortner Joseph G. 
Published: February 2007

AbstractTwenty‐one patients undergoing gastrectomy for adenocarcinoma of the stomach died during the first two postoperative weeks and were subjected to autopsy. They all had “curative” resections for lesions confined to the stomach and the regional lymph nodes. Autopsy revealed distant metastasis in ten of 13 patients who had (TNM) stage III disease at the time of surgery. There was no residual disease in patients with stage I and II lesions (P <0.01). The study suggests that, in most cases, stage III gastric adenocarcinomas have already spread beyond the confines of gastrectomy at the time of operation.
Malignant lentigo‐melanoma—A comparative histological and electron microscopy study
Authors: Bigotti Aldo , De Martino Cesare , Natali Piergiorgio , Sciarretta Francesco , Colizza Sergio 
Published: February 2007

AbstractWe examined, by light and electron microscopy, three cases of malignant lentigo, one of which was in the vertical growth phase. The purpose of our work was to compare the diverse patterns between superficial spreading melanoma and malignant lentigo. The observations suggest the following major findings: 1) the cells of malignant lentigo differ from normal melanocytes, and in the same specimen they differ from one another; 2) in malignant lentigo, melanosomes at stage II‐IV are visible; and 3) in spreading melanoma, the melanosomes do not attain complete maturation. These morphological features explain the different behaviour of these two types of tumors.
Studies on the role of oral contraceptive use in the etiology of benign and malignant liver tumors
Authors: Mettlin Curtis , Natarajan Nachimuthu 
Published: February 2007

AbstractStudies involving the role of oral contraceptive use in the etiology of benign and malignant liver tumors are reviewed. The evidence from these studies strongly suggests that there is a relationship between the use of oral contraceptives and liver tumors. The actual risk appears related to duration of usage and may also be related to the type of contraceptive steroid used. Further investigation is required determine the oncogenic potential of oral contraceptives and the malignant potential of benign tumors.
Sarcomas of the breast: Homogenous or heterogenous?
Authors: Khanna Sushila , Gupta Saroj , Khanna N. N. 
Published: February 2007

AbstractEighteen cases of sarcomas of the breast are reported. Cases could be divided into two groups histogenetically. Group A, malignant cystosarcoma phylloides (14 cases); and Group B, pure sarcomas (4 cases). The malignant cystosarcoma phylloides occurred in the fourth decade, had longer duration of illness invariably followed by sudden increase in the size of the tumor, had a striking mucoid and slimy look grossly, and showed discernable epithelial elements histologically. In the event of their recurrence the ductal elements were not seen microscopically. Contrarily, Group B cases presented in the sixth decade were rapidly growing from the beginning, and grossly were fleshy and haemorrhagic. Microscopically these did not reveal any epithelial component. There was poor correlation between cytologic malignancy and the biologic behavior in Group A. Mode of treatment seems more important in determining the subsequent course of the disease. Simple mastectomy with follow‐up appears to be adequate in the majority of cases.