bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing New York City’s COVID-19 Vaccine Rollout Strategy: A Case for Risk-Informed Distribution
Authors: Schwalbe Nina , Nunes Marta C. , Cutland Clare , Wahl Brian , Reidpath Daniel 
Published: April 2024

Abstract This study reviews the impact of eligibility policies in the early rollout of the COVID-19 vaccine on coverage and probable outcomes, with a focus on New York City. We conducted a retrospective ecological study assessing age  65+, area-level income, vaccination coverage, and COVID-19 mortality rates, using linked Census Bureau data and New York City Health administrative data aggregated at the level of modified zip code tabulation areas (MODZCTA). The population for this study was all individuals in 177 MODZCTA in New York City. Population data were obtained from Census Bureau and New York City Health administrative data. The total mortality rate was examined through an ordinary least squares (OLS) regression model, using area-level wealth, the proportion of the population aged 65 and above, and the vaccination rate among this age group as predictors. Low-income areas with high proportions of older people demonstrated lower coverage rates (mean vaccination rate 52.8%; maximum coverage 67.9%) than wealthier areas (mean vaccination rate 74.6%; maximum coverage 99% in the wealthiest quintile) in the first 3 months of vaccine rollout and higher mortality over the year. Despite vaccine shortages, many younger people accessed vaccines ahead of schedule, particularly in high-income areas (mean coverage rate 60% among those 45–64 years in the wealthiest quintile). A vaccine program that prioritized those at greatest risk of COVID-19-associated morbidity and mortality would have prevented more deaths than the strategy that was implemented. When rolling out a new vaccine, policymakers must account for local contexts and conditions of high-risk population groups. If New York had focused limited vaccine supply on low-income areas with high proportions of residents 65 or older, overall mortality might have been lower.
Increased epicardial adipose tissue thickness as a sign of subclinical atherosclerosis in patients with rheumatoid arthritis and ıts relationship with disease activity ındices
Authors: Keleşoğlu Dinçer Ayşe Bahar , Şahan Haluk Furkan 
Published: April 2024

AbstractEpicardial adipose tissue is a novel cardiometabolic risk factor and indicator of subclinical atherosclerosis. We aimed to evaluate the epicardial adipose tissue thickness in rheumatoid arthritis (RA) patients and its association with disease activity scores. A total of 81 rheumatoid arthritis patients and 70 age- and sex-matched healthy individuals were recruited for this cross-sectional study. Epicardial adipose tissue thickness (EATT) was measured by transthoracic two-dimensional echocardiography. Tender and swollen joint counts were recorded at the time of inclusion. The laboratory tests included erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor, anti-citrullinated protein antibodies, and serum lipid levels. Disease activity was calculated based on Disease Activity Scores for 28 joints (DAS-28) ESR and CRP, the Simple Disease Activity Index (SDAI), and the Clinical Disease Activity Index (CDAI). Epicardial adipose tissue thickness was significantly higher in the RA patients compared to the healthy controls (p < 0.001). We found statistically significant correlations of EATT with all disease activity indices (p < 0.001) and CRP (p = 0.002). According to a cut-off value of 6.4 mm determined for epicardial adipose tissue thickness, the RA patients with thickness ≥ 6.4 mm had higher disease activity scores and CRP levels. In the multivariable regression analysis, only SDAI score was found as an independent risk factor for increased EATT (OR, (95%CI), 13.70 (3.88–48.43), p < 0.001). Epicardial adipose tissue thickness measurement by echocardiography is a reliable method for assessing subclinical atherosclerosis in rheumatoid arthritis patients, and a higher disease activity score is an independent risk factor for coronary artery disease.
Quality of life in patients with hypoparathyroidism receiving standard treatment: an updated systematic review
Authors: Büttner Matthias , Singer Susanne , Taylor Katherine 
Published: April 2024

Abstract
Purpose
Hypoparathyroidism is defined by hypocalcemia with inappropriately normal or low parathyroid hormone levels. The current standard treatment consists of lifelong calcium and/ or vitamin D supplementation. Even while on stable treatment regimens, hypoparathyroid patients might still suffer from symptoms that can negatively impact their quality of life.

Methods
A systematic literature review to identify the current knowledge regarding quality of life in patients with hypoparathyroidism receiving standard treatment was performed on November 1st, 2023. PubMed as well as Web of Science were searched. The systematic review is registered in PROSPERO (#CRD42023470924).

Results
After removal of duplicates, 398 studies remained for title and abstract screening, after which 30 were included for full-text screening. After exclusion of seven studies with five studies lacking a control population, one using a non-validated questionnaire, and one being a subsample of the larger included study, 23 studies were included in this systematic review. The majority of the included studies used a guideline-conform definition of hypoparathyroidism, and the SF-36 was the most often applied tool. Almost all studies (87%) reported statistically significantly lower scores in at least one quality of life domain compared to a norm population or controls.

Conclusion
Patients with hypoparathyroidism receiving standard treatment report impairments in quality of life. The reasons for these impairments are probably multifaceted, making regular monitoring and the inclusion of various professionals necessary.
Hypertension as predictive factor for bevacizumab-containing first-line therapy in metastatic breast and colorectal cancer in BRECOL (GEICAM/2011-04) study
Authors: Rodríguez-Lescure Álvaro , Gallego Javier , Garcia-Alfonso Pilar , Massuti Bartomeu , Márquez Raúl , Calvo Lourdes , Sánchez-Rovira Pedro , Antón Antonio , Chacón José Ignacio , Ciruelos Eva , Ponce Jose Juan , Santaballa Ana , Valladares-Ayerbes Manuel , Dueñas María Rosario , Alonso Vicente , Aparicio Jorge , Encinas Sara , Robles Luis , Escudero María José , Caballero Rosalía , Bezares Susana , de la Haba-Rodriguez Juan 
Published: April 2024

Abstract
Background
Retrospective data suggest an association between bevacizumab efficacy and the incidence of arterial hypertension (AHT). Additionally, epigenetic mechanisms have been related to AHT.

Methods
This prospective observational study conducted by GEICAM Spanish Breast Cancer Research Group included metastatic breast (MBC) or colorectal (mCRC) cancer patients treated with bevacizumab-containing chemotherapy as first-line treatment. Blood pressure (BP) levels were measured (conventional and 24-h Holter monitoring) at baseline and up to cycle 3. Primary endpoint assessed BP levels increase as predictive factor for progression-free survival (PFS). Germline DNA methylation profile was explored in pre-treatment blood samples; principal component analysis was used to define an epigenetic predictive score for increased BP levels.

Results
From Oct-2012 to Jul-2016, 143 (78 MBC and 65 mCRC) patients were included. The incidence of AHT according to guidelines was neither predictive of PFS nor of best overall tumor response (BOR). No statistically significant association was observed with systolic BP nor diastolic BP increment for PFS or BOR. Grade 3 and 4 adverse events were observed in 37 and 5% of patients, respectively. We identified 27 sites which baseline methylation status was significantly associated to BP levels increase secondary to bevacizumab-containing chemotherapy.

Conclusions
Neither the frequency of AHT nor the increase of BP levels were predictive of efficacy in MBC and mCRC patients treated with bevacizumab-containing chemotherapy.

Clinical trial registry
ClinicalTrials.gov Identifier: NCT01733628.
Individual differences in short-term social dynamics: Theoretical perspective and empirical development of the social dynamics scale
Authors: Wrzus Cornelia , Roos Yannick , Krämer Michael D. , Richter David 
Published: April 2024

AbstractPeople have a need to form and maintain fulfilling social contact, yet they differ with respect to with whom they satisfy the need and how quickly this need is deprived or overly satiated. These social dynamics across relationships and across time are theoretically delineated in the current article. Furthermore, we developed a questionnaire to measure individual differences in three aspects of such social dynamics: (a) Family-friends interdependence, (b) Social deprivation, and (c) Social oversatiation. In a longitudinal study spanning 9 weeks in spring 2020, in total 471 participants (18–75 years, 47% women) answered the newly developed items on social dynamics, questionnaires on social dispositions (e.g., affiliation motive, need to be alone, social anxiety), and questions on personal and indirect contact with family and friends during nationwide contact restrictions related to COVID-19. The results showed that individual differences in Family-friends interdependence, Social deprivation, and Social oversatiation can be measured reliably, validly, and with predictive value for changes in daily contact as contact restrictions were loosened. We discuss potential applications of the Social Dynamics Scale (SDS) for studying social relationships in healthy and clinical populations, and conclude that the brief self-report questionnaire of social dynamics can be useful for situations and samples where direct behavioral observations are not feasible.
The Spectrum of Response Bias in Trauma Reports: Overreporting, Underreporting, and Mixed Presentation
Authors: Boskovic Irena , Giromini Luciano , Katsouri Aria , Tsvetanova Elizabet , Fonse Josephine , Merckelbach Harald 
Published: April 2024

AbstractTypically, research on response bias in symptom reports covers two extreme ends of the spectrum: overreporting and underreporting. Yet, little is known about symptom presentation that includes both types of response bias simultaneously (i.e., mixed presentation). We experimentally checked how overreporting, underreporting, and mixed reporting reflect in trauma symptom reports. Undergraduate students (N = 151) were randomly allocated to one of four conditions: control group (n = 40), overreporting (n = 37), underreporting (n = 36), or a mixed reporting (n = 38) group. The control group was asked to be honest, whereas the simulation groups received instructions they were expected to be able to relate to. Participants were administered a PTSD checklist, the Supernormality Scale-Revised, which screens for symptom denial, and the Inventory of Problems-29, which gauges overreporting. For all three measures, group differences were significant (F(3, 147) > 13.78, ps < . 001, ɳ2 > .22), with the overreporting group exhibiting the most severe symptom presentation and the underreporting group endorsing the fewest symptoms, while the mixed group almost perfectly imitated the results of the control group on all measures. Thus, instructing individuals to strategically exhibit both overreporting, to a functional degree, and underreporting results in a symptom presentation that is relatively similar to genuine performance. To optimize accuracy statistics, researchers might want to consider including such mixed group condition in future simulation studies.
A Study on Social Inclusion of Humanoid Robots: A Novel Embodied Adaptation of the Cyberball Paradigm
Authors: Roselli Cecilia , Marchesi Serena , Russi Nicola Severino , De Tommaso Davide , Wykowska Agnieszka 
Published: April 2024

AbstractAs social robots are being built with the aim of employing them in our social environments, it is crucial to understand whether we are inclined to include them in our social ingroups. Social inclusion might depend on various factors. To understand if people have the tendency to treat robots as their in-group members, we adapted a classical social psychology paradigm, namely the “Cyberball game”, to a 3-D experimental protocol involving an embodied humanoid robot. In our experiment, participants played the ball-tossing game with the iCub robot and another human confederate. In our version, the human confederate was instructed to exclude the robot from the game. This was done to investigate whether participants would re-include the robot in the game. In addition, we examined if acquired technical knowledge about robots would affect social inclusion. To this aim, participants performed the Cyberball twice, namely before and after a familiarization phase when they were provided with technical knowledge about the mechanics and software related to the functionality of the robot. Results showed that participants socially re-included the robot during the task, equally before and after the familiarization session. The familiarization phase did not affect the frequency of social inclusion, suggesting that humans tend to socially include robots, independent of the knowledge they have about their inner functioning.
Frequency and performance relevance of parent-coaches in competition-oriented sports
Authors: Straub Gunter , Plessner Henning 
Published: April 2024

AbstractThe occurrence of children being coached by their parents in the world of sport is a well-known phenomenon, but one that remains insufficiently researched. It is rather unclear how common this is and there are very different assessments of whether it is more of an advantage or a disadvantage to be trained by one’s own parents. In the first study, we assess the frequency of occurrence of parent-coaches as well as the duration of these collaborations and their developmental location in the lives of the offspring. Results from a cross-sport survey and a soccer-specific survey indicate that a notable proportion of performance-oriented male and female senior athletes (19 and 34%, respectively) have been coached by their own parents at some point (χ2 [1, N = 291] = 7.770, p = 0.005, V = 0.163). In the second study, we address the question of the relevance of parent-coaches to athletic achievement. In this regard, the hypothesis that the proportion of male soccer players who were coached by their parents is larger in higher-ranking amateur leagues (38%) than in lower-ranking leagues (28 and 14%) was empirically confirmed (χ2 [2, N = 331] = 11.950, p = 0.003, V = 0.190). Thus, it can be assumed that about one fifth of all performance-oriented senior athletes had been coached by their own parents for some time. Moreover, the fact of having been trained by one’s own parents can in principle be regarded as a conducive condition for the athletic development of adolescents.
Efficacy and safety of lenalidomide in the treatment of B-cell non-Hodgkin lymphoma
Authors: Liu Yang , Li Yanju , Zhang Chike , Yang Xu , Yang Bo , Cheng Jinyang , Chen Juan , Yuan Xiaoshuang , Li Ya , Chen Ying , Zhang Fengqi , Tang Dongxin , He Zhixu , Wang Feiqing 
Published: April 2024

Abstract
Background
The combination of rituximab and chemotherapy is a first-line treatment for patients with B-cell non-Hodgkin lymphoma. Lenalidomide is an immunomodulatory drug that has shown promising properties and activity in a variety of hematological malignancies. This study evaluated the efficacy and safety of lenalidomide-based regimens in the treatment of B-cell non-Hodgkin lymphoma.

Methods
The PubMed, Science Direct, ClinicalTrials.gov, and Web of Science databases were searched for relevant studies published up to May 2022. Studies with patients diagnosed with non-Hodgkin B-cell lymphoma, who were randomly assigned to a lenalidomide treatment group or a non-lenalidomide control group were considered for inclusion in this review and meta-analysis. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) of the time-to-event outcomes and risk ratios (RRs) with 95% CIs of dichotomous data were estimated.

Results
A total of 3593 patients from 10 studies were evaluated. The results of the pooled analysis indicated that the lenalidomide-based regimen was associated with prolonged overall survival (HR, 0.85; 95% CI 0.74–0.97; P = 0.02) and progression-free survival (HR, 0.70; 95% CI 0.57–0.88; P = 0.002). Significant differences were found in the overall response rate (RR, 1.18; 95% CI 1.04–1.33; P = 0.01) and complete response rate (RR, 1.18; 95% CI 1.00–1.39; P = 0.05) between the treatment and control groups.

Conclusions
Lenalidomide appears to be a promising therapeutic agent that offers the possibility of a novel combination of chemotherapy free regimen for patients with B-cell non-Hodgkin lymphoma.
Shaping and enhancing resilient forests for a resilient society
Authors: Cantarello Elena , Jacobsen Jette Bredahl , Lloret Francisco , Lindner Marcus 
Published: April 2024

AbstractThe world is currently facing uncertainty caused by environmental, social, and economic changes and by political shocks. Fostering social-ecological resilience by enhancing forests’ ability to provide a range of ecosystem services, including carbon sequestration, habitat provision, and sustainable livelihoods, is key to addressing such uncertainty. However, policy makers and managers currently lack a clear understanding of how to operationalise the shaping of resilience through the combined challenges of climate change, the biodiversity crisis, and changes in societal demand. Based on a scientific literature review, we identified a set of actions related to ecosystem services, biodiversity conservation, and disturbance and pressure impacts that forest managers and policy makers should attend to enhance the resilience of European forest systems. We conclude that the resilience shaping of forests should (1) adopt an operational approach, which is currently lacking, (2) identify and address existing and future trade-offs while reinforcing win–wins and (3) attend to local particularities through an adaptive management approach.
MHD Effects on the Peristaltic Transport of Non-Newtonian Eyring–Powell Fluid with Heat and Mass Transfer in an Inclined Uniform Channel
Authors: Gudekote Manjunatha , Choudhari Rajashekhar , Sanil Prathiksha , Hadimani Balachandra , Vaidya Hanumesh , Prasad Kerehalli Vinayaka 
Published: April 2024

AbstractThe primary focus of the current study is to examine the effect of magnetohydrodynamics on the peristaltic motion of Eyring–Powell fluid. The Navier–Stokes equations, renowned for their intricate nature, form the foundation of the mathematical model utilised in this investigation. However, the model has been simplified through specific assumptions to facilitate analysis. The model assumes explicitly a long wavelength and a low Reynolds number. This study also investigates the effect of wall characteristics on peristalsis in the presence of a magnetic field. Additionally, variable liquid properties such as varying viscosity and thermal conductivity are also considered in the study. The governed nonlinear equations are solved with multiple slip conditions to obtain the velocity, temperature, concentration and streamline profiles. Different waveforms on velocity profiles are also studied. A parametric evaluation makes the analysis more accessible, and the results are graphically depicted using MATLAB R2023a software. The findings of this study shed light on the substantial impact of the magnetic parameter and varying viscosity on fluid properties.
Clinico-pathological factors associated with radioiodine refractory differentiated thyroid carcinoma status
Authors: Schubert L. , Mbekwe-Yepnang A. M. , Wassermann J. , Braik-Djellas Y. , Jaffrelot L. , Pani F. , Deniziaut G. , Lussey-Lepoutre C. , Chereau N. , Leenhardt L. , Bernier M- O. , Buffet C. 
Published: April 2024

Abstract
Purpose
Risk factors for developing radioiodine refractory thyroid cancer (RAIR-TC) have rarely been analyzed. The purpose of the present study was to find clinical and pathological features associated with the occurrence of RAIR-disease in differentiated thyroid cancers (DTC) and to establish an effective predictive risk score.

Methods
All cases of RAIR-DTC treated in our center from 1990 to 2020 were retrospectively reviewed. Each case was matched randomly with at least four RAI-avid DTC control patients based on histological and clinical criteria. Conditional logistic regression was used to examine the association between RAIR-disease and variables with univariate and multivariate analyses. A risk score was then developed from the multivariate conditional logistic regression model to predict the risk of refractory disease occurrence. The optimal cut-off value for predicting the occurrence of RAIR-TC was assessed by receiver operating characteristic (ROC) curves and Youden’s statistic.

Results
We analyzed 159 RAIR-TC cases for a total of 759 controls and found 7 independent risk factors for predicting RAIR-TC occurrence: age at diagnosis ≥ 55, vascular invasion, synchronous cervical, pulmonary and bone metastases at initial work-up, cervical and pulmonary recurrence during follow-up. The predictive score of RAIR-disease showed a high discrimination power with a cut-off value of 8.9 out of 10 providing 86% sensitivity and 92% specificity with an area under the curve (AUC) of 0.95.

Conclusion
Predicting the occurrence of RAIR-disease in DTC patients may allow clinicians to focus on systemic redifferentiating strategies and/or local treatments for metastatic lesions rather than pursuing with ineffective RAI-therapies.
A Systematic Examination of Texas School District Websites for Suicide Prevention Information
Authors: Ibarra Carmen , Reinbergs Erik J. , Anderson Jacqueline R. , Roberson Anthony J. 
Published: April 2024

AbstractYouth suicide and related behaviors continue to be a significant public health concern in the USA. Multiple approaches across settings, including schools, are required to address this multi-faceted public health concern. The Texas Suicide Safer Schools Report recommended that districts post suicide prevention information on their websites as one piece of more comprehensive suicide prevention initiatives. However, there is no examination in the literature on whether this recommendation has been implemented and what, if any, information is accessible to parents and students about suicide on school district websites. This study quantifies the suicide prevention information available on a random sample of 20% of all Texas school district websites (N = 242) and conducts exploratory analyses to examine what district features are associated with an increased likelihood of posting this information. Results indicate that 53% of the sampled websites contained any suicide prevention information. Of the websites containing this information, the most frequent types posted were the numbers of suicide prevention hotlines followed by links to professional organizations. Significant relationships were found between Hispanic/Latino enrollment and information available in Spanish, independent school districts (vs. charters), and posted suicide prevention information, as well as total district enrollment and posted suicide prevention information. Implications and targeted efforts for improvement are discussed.