bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oxidative Stress and Thrombophilia: Focus on Pregnancy-Related Pathophysiological Mechanisms
Authors: Dimitrijevic A , Jakovljevic V , Jovic N , Djuric J , Andric K , Jovic J Joksimovic 
Published: March 2024

Abstract
Thrombophilia, characterized by an increased tendency to form blood clots, presents a substantial risk during pregnancy, potentially impacting maternal and fetal outcomes. This review explores the intricate relationship between thrombophilia and oxidative stress, shedding light on their combined influence on blood clot formation. Specifically, endothelial dysfunction, driven by oxidative stress, emerges as a pivotal factor in thrombophilia, setting the stage for increased platelet activation and altered coagulation factors. Factors like Factor V Leiden mutation, Prothrombin G20210A mutation, and deficiencies in antithrombin, protein C, and protein S contribute to the pro-thrombotic state observed in thrombophilia. Furthermore, inflammation, closely intertwined with oxidative stress, exacerbates the risk of blood clot formation. Inflammatory responses lead to endothelial activation, altered endothelial function, and increased adhesion molecules expression, disrupting the delicate balance between pro- and anti-coagulant factors. Chronic inflammatory conditions, such as autoimmune disorders, potentiate a persistent state of heightened clotting risk. Additionally, impaired antioxidant defenses compound the prothrombotic state by allowing the accumulation of reactive oxygen species, thereby contributing to oxidative stress-induced endothelial dysfunction. Understanding the interplay between these factors is crucial for tailored thrombophilia management, particularly in pregnancy. Treatment strategies encompass a multifaceted approach, including anticoagulant medications, lifestyle modifications, and targeted interventions to improve endothelial health. The complex nature of thrombophilia underscores the need for a collaborative healthcare approach, involving hematologists and high-risk pregnancy specialists. Early detection, vigilant monitoring, and timely intervention are paramount in mitigating risks for both mother and baby.
Explainable AI for binary and multi-class classification of leukemia using a modified transfer learning ensemble model
Authors: Deshpande Nilkanth Mukund , Gite Shilpa , Pradhan Biswajeet 
Published: March 2024

Abstract
In leukemia diagnosis, automating the process of decision-making can reduce the impact of individual pathologists' expertise. While deep learning models have demonstrated promise in disease diagnosis, combining them can yield superior results. This research introduces an ensemble model that merges two pre-trained deep learning models, namely, VGG-16 and Inception, using transfer learning. It aims to accurately classify leukemia subtypes using real and standard dataset images, focusing on interpretability. Therefore, the use of Local Interpretable Model-Agnostic Explanations (LIME) is employed to achieve interpretability. The ensemble model achieves an accuracy of 83.33% in binary classification, outperforming individual models. In multi-class classification, VGG-16 and Inception reach accuracies of 83.335% and 93.33%, respectively, while the ensemble model reaches an accuracy of 100%.
The therapeutic effect of ultrasound targeted destruction of schisandrin A contrast microbubbles on liver cancer and its mechanism
Authors: Wang Xiaohui , Wang Feng , Dong Pengfei , Zhou Lin 
Published: March 2024

Abstract

Background
The aim of the study was to explore the therapeutic effect of ultrasound targeted destruction of schisandrin A contrast microbubbles on liver cancer and its related mechanism.

Materials and methods
The Span-PEG microbubbles loaded with schisandrin A were prepared using Span60, NaCl, PEG-1500, and schisandrin A. The loading rate of schisandrin A in Span-PEG composite microbubbles was determined by ultraviolet spectrophotometry method. The Walker-256 cell survival rate of schisandrin A was determined by 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay. The content of schisandrin A in the cells was determined by high performance liquid chromatography. Ultrasound imaging was used to evaluate the therapeutic effect in situ. Enzyme linked immunosorbent assay (ELISA) was used to measure the content of inflammatory factors in serum. Hematoxylin-eosin (HE) staining was used to observe the pathological changes of experimental animals in each group. Immunohistochemistry was used to detect the expression of hypoxia inducible factor-1α (HIF-1α), vascular endothlial growth factor (VEGF) and vascular endothelial growth factor receptor 2 (VEGFR-2) in tumor tissues, and western blot was used to detect the protein expression of phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway in tumor tissues.

Results
The composite microbubbles were uniform in size, and the particle size distribution was unimodal and stable, which met the requirements of ultrasound contrast agents. The loading rate of schisandrin A in Span-PEG microbubbles was 8.84 ± 0.14%, the encapsulation efficiency was 82.24±1.21%. The IC50 value of schisandrin A was 2.87 μg/mL. The drug + microbubbles + ultrasound (D+M+U) group had the most obvious inhibitory effect on Walker-256 cancer cells, the highest intracellular drug concentration, the largest reduction in tumor volume, the most obvious reduction in serum inflammatory factors, and the most obvious improvement in pathological results. The results of immunohistochemistry showed that HIF-1α, VEGF and VEGFR-2 protein decreased most significantly in D+M+U group (P < 0.01). WB results showed that D+M+U group inhibited the PI3K/AKT/mTOR signaling pathway most significantly (P < 0.01).

Conclusions
Schisandrin A had an anti-tumor effect, and its mechanism might be related to the inhibition of the PI3K/AKT/mTOR signaling pathway. The schisandrin A microbubbles could promote the intake of schisandrin A in tumor cells after being destroyed at the site of tumor under ultrasound irradiation, thus playing the best anti-tumor effect.
Reshaping Prognosis: Atrial fibrillation ablation in a case of severe tachycardiomyopathy in a young patient
Authors: Matei Diana-Cristina , Nistor Zamfira-Claudia , Burcin Alexandru Paul , Dragotoiu Nic Claudiu , Mandeş Leonard Alexandru , Antohi Elena Laura , Sipos Sergiu-Nicolae 
Published: March 2024

Abstract
Tachycardiomyopathy, characterized by ventricular systolic dysfunction resulting from persistent tachycardia, poses a significant challenge in cardiovascular disease management. This article presents the case of a 31-year-old male patient with dilated cardiomyopathy and recurrent persistent atrial fibrillation, admitted due to heart failure decompensation. Ischemic and inflammatory etiologies for heart failure were ruled out in prior assessments. Despite multiple antiarrhythmic drugs and attempted electrical cardioversion, sinus rhythm was not maintained. Echocardiography confirmed a decline in the already reduced ejection fraction. Atrial fibrillation cryoablation was performed, and procedural specifics are detailed. Subsequent follow-up visits revealed a noteworthy improvement in exercise tolerance and ventricular function. This case underscores the importance of considering tachycardiomyopathy in the differential diagnosis of new-onset or worsening heart failure and highlights the potential for symptom resolution and ventricular function recovery with atrial fibrillation ablation.
Usability Study of the Mommy-Be App: Exploring the Experience of Breastfeeding Mothers in Eastern Indonesia
Authors: Syam Azniah , Dewi Indra , Firawati Firawati 
Published: March 2024

Objective: The rise of mobile health (mHealth) apps has brought attention to their potential in supporting breastfeeding mothers and preventing postpartum depression (PPD). This study aims to evaluate the usability of Mommy-Be, a mobile phone app designed to support breastfeeding women and help them to acknowledge of their mental health and breastfeeding efficacy during lactation period.

Theoretical Framework: This study uses Usability theory to analyze the use of mHealth applications that proposed by Nielsen model.

Method: This study combines quantitative and qualitative methods, that asses Mommy-Be app's usability among breastfeeding mothers using the Mobile Application Usability Questionnaire (MAUQ) and conducted in-depth interviews with a subset of participants. The study included 50 breastfeeding mothers in Makassar, Indonesia, who were primarily between the ages of 19 and 42 and had diverse educational and employment backgrounds. Four weeks after using the Mommy-Be app, revealed a generally positive impression of the application.

Result: Based on MAUQ three dimensions, ease of use, interface satisfaction, usefulness, this study has been determined that the utilization of a Mommy-Be application is both acceptable and feasible as a mobile health (mHealth) solution for breastfeeding mothers. The mothers experience revealed diverse user impressions of the Mommy-Be application. Participants generally found it easy to use, with a favorable interface preference. Participants expressed various benefits of using Mommy-Be, including increased awareness of breastfeeding activities, assistance in meeting nutritional needs, and early detection of postpartum depressive disorders.

Recommendations: To enhance the application's utility, participants suggested improvements, such as data export capabilities, better module integration, consideration of the target audience's resources regarding internet access and the inclusion of educational content, such as the provision of interconnection with multiple lactation counsellors.
The Role of Forensic Accounting to Reduce Financial Corruption Practices and Improving the Quality of Financial Reports
Authors: Bakhit Mashael Abdelrahim Abdelrahman 
Published: March 2024

Purpose: The study aims to identify the role of forensic accounting in reducing financial corruption practices and improving the quality of financial reports by applying it to Saudi joint stock companies.

Methodology: the study used descriptive approach, conducted a questionnaire to collect data and distributed it to the study’s population consisting of shareholders, investors, and workers in joint-stock companies in the Kingdom of Saudi Arabia.

Results and conclusion: The most important results of the study were that forensic accounting played a major role in combating financial corruption and business sustainability, and that academic and practical qualifications have a very important impact in discovering financial corruption, and the effectiveness of forensic accounting also led to improving the quality of financial reports. The researcher also recommends the necessity of adopting the subject of forensic accounting within the educational curriculum as a basic subject, as a preliminary step toward advancing the profession of forensic accounting, cooperating with educational institutions and investing in appropriate technology.

Originality/value:The study is distinguished that it addresses the role of forensic accounting in improving the suitability and credibility of financial reports and business sustainability in the Kingdom of Saudi Arabia through cooperation with educational institutions in establishing the concept of Forensic accounting and the best use of technology.
O IMPACTO DA COVID-19 EM PARQUE URBANO DO AGRESTE PERNAMBUCANO
Authors: Rocha Lucas de Lucena , Vigoderis Ricardo Brauer , Silva João Manoel da , Lima Aymê Fernanda de Almeida Melo de , Silva José Robson Alves Ferreira da , Leite Glaudemir Santos , Silva Rodriga Jeocona , Pachêco Carla Renata Xavier 
Published: March 2024

Objetivo: Analisar as modificações feitas em Parques Urbanos como o Parque Euclides Dourado, localizado no município de Garanhuns/PE, a fim de proporcionar seu uso com segurança em períodos de contágio de doenças como na pandemia da covid-19.

Referencial Teórico: Os Parques Urbanos se apresentam como alternativas viáveis para a realização de atividade física, e para restauração da fadiga mental. Com a pandemia da covid-19, as dinâmicas de uso foram modificadas para mitigação de contágio.

Método: Para a elaboração da pesquisa de campo, utiliza-se a metodologia de contagem e registro da vida urbana do livro How to Study Public life de Jan Gehl e Birgitte Svarre (2013). A metodologia consiste na contagem; elaboração de estudo de fluxos e percursos de pedestres; mapeamento e registro fotográfico, realizados através de pesquisa de campo.

Resultados: Constatou-se que estudos capazes de mensurar a eficácia da mitigação de contágio ainda são escassos e por isso é necessário o desenvolvimento de tecnologias e metodologias específicas para o avanço no campo científico nessa área de estudo.

Implicações da pesquisa: Os resultados deste trabalho são de grande relevância para o desenvolvimento sustentável não só apenas do Parque Euclides Dourado, mas sim de todos os Parques Urbanos, já que são capazes de proporcionar a prática de atividade física, relaxamento e biofilia.

Originalidade/valor: A compreensão das modificações das dinâmicas de equipamentos públicos, como os parques urbanos, pode fazer com que se as cidades estejam mais preparadas para o enfrentamento de crises sanitárias semelhantes, no futuro.
Analisis Karakteristik Dismenore pada Remaja Putri
Authors: Rahmayanti Alfenia , Jafar Fahriani Iatiqamah , Rijai Laode 
Published: March 2024

Menstrual pain or dysmenorrhea is pain felt during menstruation so that it can interfere with a woman's daily activities. Usually women experience discomfort during menstruation, such as cramps and are usually accompanied by nausea and dizziness. The aim of this research is to determine the characteristics of young women who experience dysmenorrhea at SMKN 1 Muara Bengkal. This research is descriptive in nature with an observation method. It was found that the incidence of dysmenorrhea occurred most frequently in respondents who were 16 years old at 36.67%, at menarche age 12-13 years at 63.33%, with a duration of menstrual pain of 1 day at 40.00%, respondents did not take care of the pain. amounted to 66.67%, respondents with symptoms of dizziness amounted to 60.00%, and it was found that 76.67% of respondents said that menstrual pain could affect activities. So it can be concluded that there is no relationship between age, age of menarche, duration of menstrual pain, treatment during menstrual pain, other symptoms during dysmenorrhea which can influence the occurrence of dysmenorrhea.
Keywords: Menstruation, dysmenorrhea, menstrual pain, teenage girls

Abstrak
Nyeri haid atau dismenore adalah nyeri yang dirasakan pada saat menstruasi sehingga dapat mengganggu aktifitas sehari-hari wanita. Biasanya wanita mengalami rasa yang tidak nyaman pada saat menstruasi, seperti keram dan biasanya disertai mual dan pusing. Tujuan penelitian ini untuk mengetahui gambaran karakteristik remaja putri yang mengalami dismenore di SMKN 1 Muara Bengkal. Penelitian ini bersifat deskriptif dengan metode observasi. Diperoleh hasil kejadian dismenore paling banyak terjadi pada responden yang memiliki 16 tahun sebesar 36,67%, memiliki usia menarche 12-13 tahun sebesar 63,33%, dengan durasi nyeri haid 1 hari sebesar 40,00%, responden tidak melakukan penanganan saat nyeri sebesar 66,67%, responden dengan gejala pusing sebesar 60,00%, dan didapatkan responden sebesar 76,67% mengatakan bahwa nyeri haid dapat mempengaruhi aktivitas. Sehingga dapat disimpulkan bahwa tidak ada hubungan antara usia, usia menarche, durasi nyeri haid, penanganan saat nyeri haid, gejala lain saat dismenore yang dapat mempengaruhi terjadinya dismenore.
Kata Kunci: Menstruasi, dismenore, nyeri haid, remaja putri
Pengaruh Kemasan Penyimpanan terhadap Kadar Senyawa Non Spesifik Kemangi (Ocimum basilicum L.) pada Suhu Tertentu
Authors: Adilah Haani , Sulistiarini Riski , Rahmawati Dewi 
Published: March 2024

Basil (Ocimum basilicum L.) contains the most phenolic compounds among other compounds. This condition contributes to the blackening of basil leaves which can reduce the economic value and quality hence the proper storage packaging is needed. This research was conducted to determine the levels of water soluble and ethanol soluble compounds, post-storage weight changes, and qualitative analysis of phenolic compounds. Basil leaves which have been harvested and sorted then packaged in aluminum foil, banana leaves, polypropylene (PP) plastic and newspaper. The storage process is carried out at a temperature of 5-8ºC for 5 days. After storage is complete, tests are carried out to determine the levels of water-soluble and ethanol-soluble compounds, post-storage weight changes, and qualitative analysis of phenolic compounds. The use of packaging influences changes in post-storage weight of basil where banana leaves have the lowest weight loss of 6%. Meanwhile, qualitative analysis of the compounds in the treatment showed that they still contained phenolic compounds.
Keywords: basil, storage packaging, compounds level

Abstrak
Kemangi (Ocimum basilicum L.) mengandung senyawa fenolik paling banyak di antara senyawa lainnya. Kondisi tersebut berperan kepada penghitaman daun kemangi yang dapat menurunkan nilai ekonomi dan kualitas sehingga dibutuhkan kemasan penyimpanan tepat. Penelitian ini dilakukan untuk mengetahui kadar senyawa larut air dan larut etanol, perubahan bobot pasca simpan, dan analisis kualitatif senyawa fenol. Daun kemangi yang telah dipanen dan disortasi kemudian dikemas ke dalam kemasan alumunium foil, daun pisang, plastik polipropilen (PP), dan kertas koran. Proses penyimpanan dilakukan pada suhu 5-8ºC selama 5 hari. Setelah penyimpanan selesai, dilakukan pengujian untuk mengetahui mengetahui kadar senyawa larut air dan larut etanol, perubahan bobot pasca simpan, dan analisis kualitatif senyawa fenol. Penggunaan kemasan berpengaruh terhadap perubahan bobot pasca simpan kemangi dimana daun pisang memiliki susut bobot paling rendah sebesar 6%. Sementara itu, analisis kualitatif senyawa pada perlakuan menunjukkan masih terkandung senyawa fenol.
Kata Kunci: kemangi, kemasan penyimpanan, kadar senyawa
Penentuan Nilai Sun Protection Factor (SPF) Ekstrak Etanol Rimpang Kunyit Hitam (Curcuma caesia ROXB.) dengan Metode Spektrofotometri UV-Vis
Authors: Ibau Miranda , Sulistiarini Riski , Salam Supriatno 
Published: March 2024

Black turmeric (Curcuma caesia ROXB.) is a species of turmeric, the Zingberaceae family which has high antioxidant activity and is closely related to sunscreen activity, which is a compound that absorbs or reflects sunlight so that it can prevent skin disorders. This research aims to determine the Sun Protection Factor (SPF) value of ethanol extract of black turmeric rhizomes using the soxletation extraction method using 96% ethanol solvent and determining the SPF value using the UV-Vis spectrophotometric method. Tests were carried out using varying extract concentrations of 100 ppm, 150 ppm, 200 ppm, 250 ppm and 300 ppm measured at a UV wavelength of 290-320 nm. The research results showed that the SPF values ??of the 100 ppm, 150 ppm, 200 ppm, 250 ppm and 300 ppm concentration series were 10,93; 10,90; 13,49; 19,31; 20,42. Based on these results, it was concluded that the high SPF values ??were found at concentrations of 250 ppm and 300 ppm, namely 19,31 and 20,42 which were included in the ultra protection category.
Keywords: Black Turmeric, SPF, UV-Vis Spectrophotometry

Abstrak
Kunyit hitam (Curcuma caesia ROXB.) merupakan salah satu spesies dari kunyit, dari family Zingberaceae yang memiliki aktivitas antioksidan yang tinggi dan memiliki hubungan erat dengan aktivitas tabir surya yang merupakan senyawa untuk menyerap atau memantulkan sinar matahari sehingga dapat mencegah gangguan pada kulit. Penelitian ini bertujuan untuk mengetahui nilai Sun Protection Factor (SPF) ekstrak etanol rimpang kunyit hitam dengan metode ekstraksi soxletasi menggunakan pelarut etanol 96% dan penentuan nilai SPF menggunakan metode spektrofotometri UV-Vis. Pengujian dilakukan dengan menggunakan variasi konsentrasi ekstrak sebesar 100 ppm, 150 ppm, 200 ppm, 250 ppm dan 300 ppm yang diukur pada panjang gelombang UV 290-320 nm. Hasil penelitian menunjukkan bahwa nilai SPF dari seri konsentrasi 100 ppm, 150 ppm, 200 ppm, 250 ppm dan 300 ppm berturut-turut 10,93; 10,90; 13,49; 19,31; 20,42. Berdasarkan hasil tersebut disimpulkan bahwa nilai SPF yang tinggi terdapat pada konsentrasi 250 ppm dan 300 ppm yakni 19,31 dan 20,42 yang termasuk dalam kategori proteksi ultra.
Kata Kunci: Kunyit Hitam, SPF, Spektrofotometri UV-Vis
Karakteristik Ekstrak Daun Kersen (Muntingia calabura L.) sebagai Kandidat Bahan Aktif dalam Formulasi Gel Sleeping Mask
Authors: Islamika Mirda Fitria , Sobah Nurus , Narsa Angga Cipta 
Published: March 2024

Kersen plant (Muntingia calabura L.) is one of the plants that has antioxidant activity. The phytochemical content in kersen plants includes flavonoids, terpenoids, steroids, phenolics, saponins and tannins. This content makes kersen plants have high antioxidant activity and potential to be formulated in the form of sleeping mask gel. Antioxidants have an important role that can neutralize free radicals in the body, where these free radicals are closely related to accelerated aging and carcinogenic. Therefore, the antioxidant activity of kersen leaf extract was tested quantitatively using a UV-Vis spectrophotometer to determine the potential of kersen plants as a source of antioxidants. The results showed that kersen plant has characteristics of blackish brown color, solid form, distinctive aroma, with an extract pH of 4.29. The content of secondary metabolite compounds in it include flavonoids, alkaloids, and tannins. The results of the antioxidant activity test of kersen leaf extract showed an IC50 value of 13.11242 and was included in the very strong category.
Keywords: Kersen Leaf, Extract, Antioxidant

Abstrak
Tumbuhan kersen (Muntingia calabura L.) merupakan salah satu tumbuhan yang memiliki aktivitas antioksidan. Kandungan fitokimia dalam tanaman kersen meliputi flavonoid, terpenoid, steroid, fenolik, saponin dan tanin. Kandungan ini menjadikan tumbuhan kersen memiliki aktivitas antioksidan yang tinggi dan berpotensi untuk diformulasikan dalam bentuk sediaan gel sleeping mask. Antioksidan memiliki peran penting yaitu dapat menetralkan radikal bebas yang ada di dalam tubuh, dimana radikal bebas ini berkaitan erat dengan percepatan penuaan dan karsinogenik. Oleh karena itu, dilakukan pengujian aktivitas antioksidan ekstrak daun kersen secara kuantitatif menggunakan spektrofotometer UV-Vis untuk mengetahui potensi tumbuhan kersen sebagai sumber antioksidan. Hasil penelitian menunjukkan bahwa tumbuhan kersen memiliki karakteristik warna coklat kehitaman, berwujud padat, aroma khas, dengan pH ekstrak 4,29. Kandungan senyawa metabolit sekunder yang ada di dalamnya antara lain flavonoid, alkaloid, dan tanin. Hasil uji aktivitas antioksidan ekstrak daun kersen menunjukkan nilai IC50 sebesar 13.11242 dan termasuk dalam kategori sangat kuat.
Kata Kunci: Daun Kersen, Ekstrak, Antioksidan