bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adoption and Use of a Risk Assessment Tool for Identifying and Controlling the Spread of Candida Auris among Admitted Patients at a Saudi Arabian Hospital
Authors: Alshahrani Fatimah , Elgujja Abba Amsami , Alsubaie Sara , Ezreqat Salah , Albarrag Ahmed , Barry Mazin , Khamis Khalifa Bin , Alabdan Lulwa , Antony Marytonia , Caparoso Jocelin , Adam Samah Mustapha , Faqihi Khalid Waleed 
Published: April 2024

Abstract

Background
The emergence of Candida auris (C. auris), a multidrug-resistant fungal pathogen, poses a significant healthcare challenge, necessitating robust risk assessment strategies for effective infection control in hospital settings.
Objective
This study aimed to assess and quantify the risk of C. auris infection in a tertiary hospital using an adapted risk assessment tool considering diverse patient factors and hospital dynamics.
Method
The study employed the 'adaptation method,' amalgamating literature review and analysis of individual patient data (IPD) to identify and quantify C. auris infection risk. Utilizing the MRSA risk assessment tool, risk factor information was derived from the literature and adapted based on IPD, ensuring context-specific relevance. The study was conducted in a 1000-bed tertiary university teaching hospital in Riyadh, triggered by the first C. auris case in 2019, covering the period from January 2020 to December 2022. The variables included admission history, comorbidities, multidrug resistant organism (MDRO) history, wounds/devices, surgeries, and antimicrobial use. The inclusion criteria targeted high-risk individuals, and the exclusion criteria focused on inpatients. The screening tool was deployed through a PowerForm in selected nursing units, with rigorous training for nurses and comprehensive data collection, monitoring, and outcome analysis. Robust statistical methods, including multivariable logistic regression and subgroup analyses, were employed to address potential biases and ensure the study's internal validity.
Results
Graphic and clinical findings were analyzed in a cohort of 68,031 patients. Notably, 9% of the patients had identified risk factors, such as septicemia, CKD, DM, or chronic lung disease. Additionally, 7% reported a history of admission to non-KSA hospitals, and 14% had contact with MDROs or ASCs. The overall prevalence of positive responses across the assessed risk factors was 6%, underscoring the relevance of these factors in the context of Candida auris infection.
Conclusion
The overall prevalence of positive responses across the assessed risk factors was 6%, emphasizing the relevance of these factors in the context of Candida auris infection. These findings contribute valuable insights for developing targeted surveillance and preventive measures in the healthcare setting.
A Comprehensive Study of Positive Body Image as a Predictor of Psychological Well-being in Anorexia Nervosa
Authors: Torres Sandra , Vieira Ana Isabel , Vieira Filipa Mucha , Miller Kylee M. , Guerra Marina Prista , Lencastre Leonor , Reis Ana Catarina , Timóteo Sertório , Nunes Patrícia , Barbosa Maria Raquel 
Published: April 2024

Abstract

Objective
Recent data suggests a close association between positive body image (PBI) and eating disorder recovery. Nevertheless, the specific mechanisms through which PBI may facilitate recovery from anorexia nervosa (AN) remain unknown. To advance understanding of these mechanisms, this study examined core indices of PBI within AN, exploring its association with emotion regulation and well-being outcomes.
Method
Data were collected from 159 female participants, 64 with AN diagnosis and 95 healthy controls (HC), who completed measures of PBI (body appreciation, functionality appreciation, and body responsiveness), emotion regulation, and psychological well-being (depression, anxiety, stress, and psychological quality of life).
Results
The AN group reported lower levels of PBI and psychological well-being, along with greater difficulties in regulating emotions, compared to the HC group. All PBI variables displayed significant correlations with the outcome variables. However, in comparison between the groups, body appreciation and functionality appreciation exhibited stronger correlations with psychological well-being in AN participants. PBI variables significantly predicted emotion regulation and psychological well-being in AN, accounting for 36–72% of the variance, with body appreciation emerging as the strongest predictor.
Discussion
These findings lend credence to the view that PBI can serve as a catalyst for psychological health. We hypothesize that enhancing PBI may establish a stronger body-mind connection, fostering interoceptive awareness crucial for emotion regulation and ultimately reducing emotional symptoms and maladaptive food-related coping in individuals with AN.
Removal effect of pollutants from stormwater runoff in shallow bioretention system with gramineous plants
Authors: Yang Jing , Luo Hui , Wang Huiteng , Qin Teng , Yang Mingyu , Chen Limin , Wu Xi , He Bao-Jie 
Published: April 2024

ABSTRACT

The bioretention system is one of the most widely used low impact development (LID) facilities with efficient purification capacity for stormwater, and its planting design has been a hot spot for research at home and abroad. In this paper, ryegrass (Lolium perenne L.), bermuda (Cynodon dactylon Linn.), bahiagrass (Paspalum notatum Flugge), and green grass (Cynodon dactylon × C .transadlensis ‘Tifdwarf’) were chosen as plant species to construct a shallow bioretention system. The growth traits and nutrient absorption ability of four gramineous plants were analyzed. Their tolerance, enrichment, and transportation capacity were also evaluated to compare plant species and their absorptive capacity of heavy metals (Cu, Pb, and Zn). Results showed that the maximum absorption rate (Imax) ranged from 22.1 to 42.4 μg/(g·h) for P and ranged from 65.4 to 104.8 μg/(g·h) for NH4+-N; ryegrass had the strongest absorption capacity for heavy metals and the maximum removal rates of Cu, Pb, and Zn by four grasses were 78.4, 59.4, and 51.3%, respectively; the bioretention cell with ryegrass (3#) was significantly more effective in purifying than the unplanted bioretention cell (1#) during the simulated rainfall test. Overall, the system parameters were optimized to improve the technical application of gramineous plants in the bioretention system.
Contenido de azúcares en raíces reservantes de 106 clones de camote (Ipomoea batatas (L.) Lam.) de la colección de germoplasma
Authors: Aliaga R. Pilar , Nieto A. Cecilia 
Published: April 2024

Se ha determinado el contenido de azúcares totales y azúcares reductores, en una muestra representativa de la colección de germoplasma mundial de camote libre de patógenos, que mantiene el Centro Internacional de la Papa (CIP). Se ha encontrado que el contenido de azúcares en las raíces de camote presenta una gran variabilidad, con un rango desde 8.26% hasta 31.65% (expresados en base seca), para azúcares totales y un rango desde 0.58 hasta 14.07% (expresados en base seca) para azúcares reductores.
Evaluación ecotoxicológica de pesticidas organofosforados sobre Daphnia magna
Authors: Burga P. Karen , Visitación F. Lizardo , Chire M. Teofilo 
Published: April 2024

La evaluación ecotoxicológica de los pesticidas organofosforados en el filtrado de suelos, metamidofos, clorpirifos y mezcla de metamidofos-clorpirifos, fue realizada utilizando como organismo de respuesta la Daphnia magna, se midió la toxicidad aguda en función del CL50 (Concentración letal media), así mismo se evaluó el efecto sinérgico de la presencia de estos pesticidas. Finalmente se determinó si existe riesgo ambiental en la actividad agrícola de la localidad de Carapongo donde se emplean estos pesticidas como protección de sus cultivos.
Efectos de la Capacitación Docente en los Profesores de la Especialidad de Ciencia, Tecnología y Ambiente de la UGEL 07 de Lima Metropolitana
Authors: Mar A. Liberio , Gonzales Ch. Celso 
Published: April 2024

En el marco del convenio Ministerio de Educación – Universidad Nacional Agraria La Molina, se desarrolló el Programa Nacional de Formación y Capacitación Permanente con la participación de 1,676 profesores que enseñan en el nivel secundario de menores, pertenecientes a la UGEL 07 Lima Metropolitana. Este proceso de capacitación se llevó a cabo durante cinco meses (agosto – diciembre 2007), desarrollando las siguientes acciones estratégicas: dictado de cursos en la modalidad presencial y no presencial (aula virtual) y las visitas de monitoreo y asesoría al docente en aula y a nivel institucional. Los cursos estuvieron distribuidos en cuatro componentes: Capacidades Comunicativas, Capacidades Lógico Matemáticas, Especialidad Académica y Currículo Escolar. Para este estudio se tomó en cuenta el dictado del componente especialidad, específicamente, de Ciencia, Tecnología y Ambiente (que articula las asignaturas de biología, química y física), con una muestra de 232 profesores; 175 de ellos ubicados en el nivel A y 75 en el nivel B (según logros alcanzados en el examen censal 2007). El instrumento de recojo de información utilizado fue la prueba de entrada y salida (test y retest), que evalúa los contenidos de la especialidad. Los reactivos fueron de selección múltiple. Este instrumento fue aplicado al inicio y al término de la capacitación. Los resultados corresponden a la calificación vigesimal que determinan niveles de logro (destacado, suficiente, intermedio y bajo). Al comparar los resultados en ambos grupos, se aprecia que la mayoría de docentes de esta especialidad alcanzan un nivel de logro superior respecto a la evaluación de inicio, lo que indica que el dictado de los cursos de especialidad ha beneficiado los niveles de desempeño de los docentes y, consecuentemente, reafirma la importancia de la actualización académica permanente de los profesores a fin de mejorar los niveles de enseñanza y aprendizaje de sus alumnos.
Perú: Desarrollo Rural y Política de Estado
Authors: Alarcón N. Jorge 
Published: April 2024

Históricamente en el Perú ha existido un divorcio entre el enfoque teórico del desarrollo rural, con un objetivo central distinto al humano, y una práctica promovida por programas y proyectos desarticulados entre sí y orientados hacía actividades que promueven acciones paternalistas y asistencialistas dirigidas a satisfacer una agenda de corto plazo. Ello explica, en buena medida, los altos niveles de pobreza y exclusión social que caracterizan a la población rural del país. Aunque en el presente, se han superado marcos conceptuales teóricos tradicionales del desarrollo rural y se ha avanzado en la incorporación de aspectos relacionados con el desarrollo humano y la conservación de los recursos naturales y el medio ambiente, aún este esfuerzo no se plasma en logros concretos derivados de políticas de Estado integradoras de planes, programas y proyectos dirigidos al cumplimiento de determinados objetivos de Estado a favor del desarrollo rural de territorios específicos. Ello deriva en la consecuente constatación que el marco teórico es necesario pero no suficiente. El enfoque de desarrollo territorial (DTR), teóricamente elegante y comprehensivo, destaca como una propuesta de desarrollo rural reciente, novedosa e integral, fuertemente influenciada por paradigmas utilizados en otras dimensiones geográficas y sociales, lo que limita su aplicación práctica. Para ser exitosa, la propuesta requiere el cumplimiento de –al menos- tres principales requisitos: (a) fortalecimiento de la ingeniería institucional, (b) avances en una genuina descentralización del país, (c) priorización de la agricultura en términos de su importancia en el desarrollo nacional. Sin tales requisitos cualquier esfuerzo de desarrollo tendrá muy pocas posibilidades de éxito.
Evaluación del Control Interno en el Sistema de Abastecimiento de la Universidad Nacional Agraria La Molina
Authors: Quiroz Q. Pedro 
Published: April 2024

Un Sistema de abastecimiento mal diseñado puede convertirse en una herramienta bastante peligrosa para la universidad; como los procedimientos no están implementados correctamente, generan retrasos en la entrega de los requerimientos a las diversas facultades de la universidad, así como la demora de atención a los proveedores. Estos son solo algunos de los varios inconvenientes que puede presentar un Sistema de abastecimiento. Por eso es necesario la evaluación del Control Interno en la Gestión del Sistema de Abastecimiento de la Universidad. Con ese fin, debe conocerse cuales son las responsabilidades y objetivos de la organización, el contexto político en donde se desenvuelve, analizar los objetivos versus los resultados y verificar las causas de los desvíos.
CRISPR and Gene Editing: A Game-changer in Drug Development
Authors: Verma Abhishek , Sharma Tarun , Awasthi Ankit 
Published: April 2024

Abstract:
CRISPR and gene editing technologies have emerged as transformative tools in medicine, offering
unprecedented precision in targeting genetic disorders and revolutionizing drug development. This review explores
the multifaceted impact of CRISPR across various medical domains, from hereditary diseases to infectious
diseases and cancer. The potential of CRISPR in personalized medicine, therapeutic innovation, and pandemic
prevention is highlighted, along with its role in reshaping traditional drug development processes. However,
alongside its promise, ethical considerations loom large, particularly regarding germline editing and
equitable access to treatments. The commercialization of CRISPR poses further challenges, raising questions
about affordability and healthcare equity. Collaboration among scientists, policymakers, and the public is emphasized
to navigate the ethical and societal implications of CRISPR responsibly. As the field advances, it is
essential to ensure that the benefits of CRISPR are realized while addressing potential risks and maintaining a
commitment to the well-being of future generations.
Role of Radiation-related Lung Function Genes in Prognosis and Immune Infiltration of Lung Adenocarcinoma
Authors: Teng Fei , Sun Xiaojing , Ran Yuge , Liu Chan , Shi Hongyun , Tian Yuan 
Published: April 2024

Background:
Lung adenocarcinoma (LUAD) is a common malignant tumor with no
obvious clinical symptoms in its early stages. Patients can be divided into radiotherapysensitive
groups (RS) and radiotherapy-resistant groups (RR) due to their varying conditions.
The therapeutic effect of radiotherapy is quite different between the two groups. Therefore, this
paper explores the role of radiation-related lung function genes in LUAD and its immune landscape.

Methods:
Firstly, we divided LUAD samples from the TCGA cohort into RS and RR groups
and analyzed differential expression to obtain differentially expressed genes (DEGs). Then,
DEGs and patients' grouping information were input into the weighted co-expression network,
and the genes in the radiotherapy-related modules were identified. Furthermore, after the intersection
of DEGs and lung function-related genes, the prognosis-related genes were obtained
through univariate Cox and Lasso-Cox analyses, respectively, and the risk model was constructed.
Finally, the differences in prognosis and immunity of the samples in the risk model
were explored. Additionally, we also performed a qPCR experiment on lung function-related
genes.

Results:
In this paper, radiation-related genes of LUAD were identified through a series of bioinformatics
analyses. By conducting enrichment analysis on these genes, several pathways related
to LUAD radiation were identified, and DEGs associated with significant prognosis were
determined. Furthermore, a radiation-related risk model of LUAD was developed. All samples
were divided into high-risk and low-risk groups based on the risk score, and the differences in
immune cell infiltration abundance and immune function between these groups were evaluated.
The qPCR experimental results demonstrated a significant difference in the expression of genes
related to lung function.

Conclusion:
The prognosis-related genes identified in this paper and the risk model created can
serve as a reference for diagnosing and treating LUAD.
Nanomaterial-based Electrochemical Sensors for Multiplex Medicinal
Applications
Authors: Traipop Surinya , Jesadabundit Whitchuta , Khamcharoen Wisarut , Pholsiri Tavechai , Naorungroj Sarida , Jampasa Sakda , Chailapakul Orawon 
Published: April 2024

Abstract::
This review explores the advancements in nanomaterial-based electrochemical sensors
for the multiplex detection of medicinal compounds. The growing demand for efficient and selective
detection methods in the pharmaceutical field has prompted significant research into the development
of electrochemical sensors employing nanomaterials. These materials, defined as functional
materials with at least one dimension between 1 and 100 nanometers, encompass metal nanoparticles,
polymers, carbon-based nanocomposites, and nano-bioprobes. These sensors are characterized
by their enhanced sensitivity and selectivity, playing a crucial role in simultaneous detection
and offering a comprehensive analysis of multiple medicinal complexes within a single sample.
The review comprehensively examines the design, fabrication, and application of nanomaterial-
based electrochemical sensors, focusing on their ability to achieve multiplex detection of various
medicinal substances. Insights into the strategies and nanomaterials employed for enhancing
sensor performance are discussed. Additionally, the review explores the challenges and future perspectives
of this evolving field, highlighting the potential impact of nanomaterial-based electrochemical
sensors on the advancement of medicinal detection technologies.
A Computational Study of Green Tea Extracts and their Derivatives as
Potential Inhibitors for Squalene Monooxygenase
Authors: Mokgopa Kabelo Phuti , Lobb Kevin A. , Tshiwawa Tendamudzimu 
Published: April 2024

Background:
According to the World Health Organisation, cardiovascular complications
have been recognized as the leading course of death between 2000 and 2019.
Cardiovascular complications are caused by excess LDL cholesterol in the body or arteries that can
build up to form a plaque. There are drugs currently in clinical use called statins that target HMGCoA
reductase. However, these drugs result in several side effects. This work investigated using
computational approaches to lower cholesterol by investigating green tea extracts as an inhibitors
for squalene monooxygenase (the second-rate-controlling step in cholesterol synthesis).

Methods:
Pharmacophore modeling was done to identify possible pharmacophoric sites based on
the pIC50 values. The best hypothesis generated by pharmacophore modeling was further validated
by atom-based 3D QSAR, where 70% of the data set was treated as the training set. Prior molecular
docking ADMET studies were done to investigate the physiochemical properties of these
molecules. Glide docking was performed, followed by molecular dynamics to evaluate the protein
conformational changes.

Results:
Pharmacophore results suggest that the best molecules to interact with the biological target
should have at least one hydrogen acceptor (A5), two hydrogen donors (D9 and D10), and two
benzene rings (R14 and R15) for green tea polyphenols and theasinensin A. ADMET result shows
that all molecules in this class have low oral adsorption. Molecular docking results showed that
some green tea polyphenols have good binding affinities, with most of these structures having a
docking score of less than -10 kcal/mol. Molecular dynamics further illustrated that the best-docked
ligands perfectly stay within the active site over a 100 ns simulation.

Conclusion:
The results obtained from this study suggest that green tea polyphenols have the
potential for inhibition of squalene monooxygenase, except for theasinensin A.
Effects of Orexin Receptor Antagonist on Cognitive Function in Adults: A
Systematic Review
Authors: Jha Divya , Garg Aakriti , Khan Mohd Ashif 
Published: April 2024

Background::
Orexin receptor antagonists (ORAs) are the emerging class of hypnotics
used for the treatment of insomnia. However, from the available literature, the effect of ORA on
cognitive functions is not clear yet. Therefore, the current study aimed to systematically evaluate the
effect of ORA on cognitive function from available clinical studies.

Methods::
The extensive literature search was conducted in various databases, including Pubmed,
Embase, Cochrane Library, and clinicaltrials.gov, using suitable keywords. The quality of the included
studies was evaluated using the Cochrane risk of bias tool (ROB2).

Results::
We obtained a total of 450 articles from different databases. Finally, 07 articles met the
inclusion criteria and were included in the current systematic review for qualitative analysis. Available
literature showed conflicting results, with few studies showing no impact of ORA on cognitive
function, while others reported dose-dependent adverse effects of ORA on cognitive function. The
risk of bias in included studies was found to be low.

Conclusion::
In conclusion, ORA is generally safe in clinical doses. However, it is important to note
that there is a dose-dependent decline in cognitive function after the administration of ORA. Therefore,
clinicians must be careful while prescribing ORA and adjust the dose as per the needs of the
individual patients and the potential risk factors.
Levetiracetam Induced Behavioural Changes in an Adult Female Patient:
A Case Report
Authors: Virani Hemangi Amrutbhai , Dabhi Hetal Kantilal , Pargi Piyushkumar Mansinh 
Published: April 2024

Background::
Levetiracetam, a relatively recent addition to antiepileptic medications,
is known for its broad-spectrum efficacy in treating partial and generalized tonic-clonic seizures
in individuals of all age groups. Despite its favourable tolerability profile, rare instances of psychiatric
side effects have been reported. This case study presents a rare occurrence of significant
behavioural changes attributed to levetiracetam in a young female patient.

Case History::
A 40-year-old woman with a long-standing history of epilepsy, well-managed
with medication, presented with abrupt-onset behavioural changes, including irritability, aggression,
crying spells, insomnia, increased talkativeness, and screaming. Notably, these behavioural
changes were unrelated to seizure activity and emerged without precedent. A dose reduction of
levetiracetam was also attempted, which proved ineffective in mitigating her symptoms.

Conclusion::
Consequently, the drug was discontinued, resulting in the resolution of the behavioural
symptoms. This case highlights levetiracetam as the likely causative factor behind the observed
significant behavioural changes.