bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of goal attainment scaling implementation practices by caregivers in randomized controlled trials
Authors: Cheema Kulpreet , Dunn Taylor , Chapman Chere , Rockwood Kenneth , Howlett Susan E. , Sevinc Gunes 
Published: March 2024

Abstract
Background
Goal attainment scaling (GAS), an established individualized, patient-centred outcome measure, is used to capture the patient’s voice. Although first introduced ~60 years ago, there are few published guidelines for implementing GAS, and almost none for its use when caregivers GAS is implemented with caregiver input. We conducted a systematic review of studies that implemented GAS with caregiver input; and examined variations in GAS implementation, analysis, and reporting.

Methods
Literature was retrieved from Medline, Embase, Cochrane, PsycInfo and CINAHL databases. We included randomized controlled trials (published between 1968 and November 2022) that used GAS as an outcome measure and involved caregiver input during goal setting.

Results
Of the 2610 studies imported for screening, 21 met the inclusion criteria. Most studies employed GAS as a primary outcome. The majority (76%) had children as study participants. The most common disorders represented were cerebral palsy, developmental disorders, and dementia/Alzheimer’s disease. The traditional five-point GAS scale, with levels from −2 to +2, was most often implemented, with −1 level typically being the baseline. However, most studies omitted essential GAS details from their reports including the number of goals set, number of attainment levels and whether any training was given to GAS facilitators.

Conclusions
GAS with caregiver input has been used in a limited number of randomized controlled trials, primarily in pediatric patients and adults with dementia. There is a variability in GAS implementation and many crucial details related to the specifics of GAS implementation are omitted from reports, which may limit reproducibility. Here we propose catalog that may be utilized when reporting research results pertaining to GAS with caregivers to enhance the application of this patient-centered outcome measure.
Modelling the propagation of properties across services in cyber-physical energy systems
Authors: Narayan Anand , Brand Michael , Huxoll Nils , Hassan Batoul Hage , Lehnhoff Sebastian 
Published: March 2024

AbstractModern power systems, referred to as cyber-physical energy systems (CPESs), are complex systems with strong interdependencies between power and information and communication technology (ICT) systems. CPESs also have dependencies between the essential grid services. For instance, coordinated voltage control depends on state estimation, which depends on measurement acquisition. Since the operation of CPESs is largely influenced by these grid services, assessing their performance is crucial for assessing the performance of a CPES. Most of these grid services are enabled by the ICT system, i.e., they rely to a high degree on ICT. Hence, properties such as availability, correctness and timeliness, which depend on the involved software, hardware and data of the ICT system, must be considered for assessing the performance of an ICT-enabled grid service. Disturbances and repairs in CPESs impact these properties, which can then propagate and affect the performance of a grid service as well as other dependent grid services. There is, therefore, a need to model the influence of the properties of software, hardware and data on ICT-enabled grid services for single services as well as across several services, resulting in a propagation of these parameters. Current literature lacks such a model, which can used not only to investigate but also to visualise the impact of these properties on the overall perfromance of a grid service as well as other dependent grid services. This paper proposes a meta model for assessing the performance of ICT-enabled grid services, which can be instantiated for different grid services considering their dependencies. A multi-dimensional operational state space, which serves as a visualisation of the performance of grid services in terms of their state trajectory, is also proposed in this paper. The contributions are then demonstrated by a case study with a state estimation service and the widely-used CIGRE medium voltage benchmark power grid augmented with an ICT system. Three scenarios with disturbances are presented to show the benefits of the contributions. Specifically, the performance of the state estimation service considering the disturbances is investigated using the meta model, and the change in performance is visualised as trajectories using the operational state space. These contributions enable new possibilities for planning and vulnerability analyses: property changes in parts of the ICT system can be simulated to investigate their consequences throughout the ICT-enabled grid services. A trajectory representing their performance can then be visualized in the state space based on which measures could be implemented to potentially improve the resilience of the service against the considered disturbances.
Population genetic analyses highlight an eastward dispersal of Puccinia striiformis f. sp. tritici from the Shaanxi province to the North China Plain
Authors: Zhou Congying , Lv Xuan , Qi Xinlei , Abdullah Ahsan , Sun Qiuyu , Ding Mingliang , Bai Yingwen , Yang Ziqian , Wang Zhifang , Ma Zhanhong 
Published: March 2024

AbstractWheat stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is a common airborne wheat disease. The frequent occurrence at a large scale in China has caused significant yield losses and poses a considerable threat to food security. To effectively manage and forecast the disease, a comprehensive understanding of the long-distance migration patterns of Pst is essential. Shaanxi province, situated in close proximity to the northwestern epidemic areas in China, plays a crucial role as a key overwintering region for Pst. However, it remains uncertain whether Pst, after winter reproduction in Shaanxi province, can extend its spread to the primary wheat regions in the North China Plain. In this study, during February and June 2022, a total of 302 Pst samples were collected from Shaanxi province and the North China Plain. Thirteen pairs of simple sequence repeat (SSR) markers were adopted to analyze the population genetic structure. It was observed that both genetic and genotypic diversities exhibited a discernible decline from the Shaanxi to the North China Plain. Moreover, Shaanxi displayed a close genetic relationship with Henan and Shandong, whereas Henan exhibited the most substantial population exchange with Shaanxi. Further analysis revealed that Shaanxi served as the primary inoculum of Pst in the investigated region, and the spread of Pst to Henan and Shandong originated from Shaanxi. As a result, the epidemics in Shandong further led to the prevailing of the disease in Hebei. Our study enhances the understanding of the epidemiological patterns of wheat stripe rust in the springtime prevalent regions of China, and it provides insights for future disease management.
New insights into the stipitate hydnoid fungi Sarcodon, Hydnellum, and the formerly informally defined Neosarcodon, with emphasis on the edible species marketed in Southwest China
Authors: Wang Di , Feng Hui , Zhou Jie , Liu Tian-Hai , Zhang Zhi-Yuan , Xu Ying-Yin , Tang Jie , Peng Wei-Hong , He Xiao-Lan 
Published: March 2024

AbstractSarcodon and Hydnellum are two ectomycorrhizal genera of important ecological and economic value in Southwest China, and they are common in the free markets in this region. It was estimated that more than 1,500 tonnes of them were sold as edible per year, but there was little information about the taxonomic placements of these edible mushrooms sold in the markets. Traditional concepts of the two genera have also been challenged recently, and circumscription of Sarcodon and the informally defined clade “Neosarcodon” remained unresolved. In the present study, specimens collected in the field and purchased from the markets in Southwest China were analyzed based on morphological characters and DNA sequences. Phylogeny of the traditional Sarcodon s. lat. and Hydnellum s. lat. was reconstructed from the combined internal transcribed spacer (ITS), nuclear large ribosomal subunit (nLSU) and RNA polymerase II second largest subunit (RPB2) dataset based on expanded samples to reevaluate the taxonomic placements of the two genera. In the present molecular analyses, four distinct clades were recovered and strongly supported: Hydnellum, Neosarcodon, Phellodon and Sarcodon. Neosarcodon is formally introduced as a generic name to include nine species previously placed in Sarcodon, and the delimitation of Sarcodon is revised based on phylogenetic and morphological studies. Phylogenetic analyses also revealed an unexpected species diversity (17 phylogenetic species) of Sarcodon and Hydnellum in the markets; nine phylogenetic species of Sarcodon and eight of Hydnellum were uncovered from the samples collected in the markets. Eight species were resolved in the traditional S. imbricatus complex, with S. imbricatus s.str. being the most common edible stipitate hydnoid fungal species. Three of the edible Hydnellum species (H. edulium, H. subalpinum, and H. subscabrosellum), and five separated from the S. imbricatus complex (Sarcodon flavidus, S. giganteus, S. neosquamosus, S. nigrosquamosus, and S. pseudoimbricatus), are described as new. Three new Chinese records (H. illudens, H. martioflavum, and H. versipelle), and the notable S. imbricatus and S. leucopus are also reported.
Potential biomarker signatures in male infertility: integrative genomic analysis
Authors: Junahar Devalina , Dwiputri Rinesia , Adikusuma Wirawan , Darmawi Darmawi , Afdal Afdal , Irham Lalu Muhammad , Suyanto Suyanto 
Published: March 2024

Abstract
Background
Studies have attributed 50% of infertility cases to male infertility, 15% of which is caused by idiopathic genetic factors. Currently, no specific biomarkers have been revealed for male infertility. Furthermore, research on genetic factors causing male infertility is still limited. As with other multifactorial genetic disorders, numerous risk loci for male infertility have been identified by genome-wide association studies (GWAS), although their clinical significance remains uncertain. Therefore, we utilized an integrative bioinformatics-based approach to identify biomarkers for male infertility. Bioinformatics analysis was performed using Open Targets Platform, DisGeNet, and GWAS Catalog. After that, the STRING database and the Cytoscape program were used to analyze protein–protein interaction. CytoHubba was used to determine the most significant gene candidates. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were used to assess biological functions that correspond to the male infertility disease pathway.

Results
We identified 305 genes associated with male infertility and highlighted 10 biological risk genes as potential biomarkers for male infertility such as TEX11, SPO11, SYCP3, HORMAD1, STAG3, MSH4, SYCP2, SYCE1, RAD21L1, and AMH. Of all the genes, we took the top three genes, namely, TEX11, SPO11, and SYCP3 as the genes that have the most potential as biomarkers.

Conclusions
TEX11, SPO11, and SYCP3 are involved in meiosis and spermatogenesis. We propose that further research in regarding these genes in detecting male infertility.
The homozygous pathogenic variant of the POMGNT1 gene identified using whole-exome sequencing in Iranian family with congenital hydrocephalus
Authors: Sabzeghabaiean Masoud , Maleknia Mohsen , Mohammadi-Asl Javad , Kazemi Hashem , Golab Fereshteh , Zargar Zohreh , Naseroleslami Maryam 
Published: March 2024

Abstract
Background
Hydrocephalus is one of the most common pathophysiological disabilities with a high mortality rate, which occurs both congenitally and acquired. It is estimated that genetic components are the etiology for up to 40% of hydrocephalus cases; however, causal mutations identified until now could only explain approximately 20% of congenital hydrocephalus (CH) patients, and most potential hydrocephalus-associated genes have yet to be determined. This study sought to find causal variations in a consanguineous family with four affected children diagnosed with hydrocephalus.

Material and methods
In this study, we evaluated twenty-five members of an extended family consisting of a nuclear family with four affected children resulting from a consanguineous couple and eighteen of their relatives, including one hydrocephalus case. The mother of this family was experiencing her 15th week of pregnancy, and cytogenetic evaluation was performed using amniocentesis to identify fetal chromosomal abnormalities. We conducted whole-exome sequencing (WES) on the genomic DNA of the proband to detect the CH-causing variants, followed by confirmation and segregation analysis of the detected variant in the proband, fetus, and family members through Sanger sequencing.

Results
Following the bioinformatic analysis and data filtering, we found a homozygous variant [NM_001243766.2:c.74G>A:p.W25X] within the protein O-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGNT1) gene confirmed by Sanger sequencing in the proband and segregated with the hydrocephalus in the family. The variant was described as pathogenic and regarded as a nonsense-mediated mRNA decay (NMD) due to the premature stop codon, which results in a truncated protein.

Conclusion
The results of the current study broadened the mutational gene spectrum of CH and our knowledge of the hydrocephalus etiology by introducing a novel homozygous variant within the POMGNT1 gene, which had never been previously reported solitary in these patients.
Safety and efficacy of brachial approach for coronary angiography and percutaneous coronary intervention
Authors: Ghanem Islam , Mesbah Mohamed , Refaat Hesham 
Published: March 2024

Abstract
Background
There are many percutaneous coronary approaches. The most commonly used one is the radial artery because of its lowest risk of adverse vascular events. However, it could not be an option in some situations as congenital radial artery hypoplasia and spasm. In these cases, the second most common access is the femoral artery. The current literature over the brachial artery access is controversial. Thus, the aim of this study was to verify the brachial artery approach's effectiveness and safety.

Results
We studied 300 patients who underwent elective coronary angiography and angioplasty in our institution with failed radial access between August 2022 and February 2023. They were classified into two groups; 150 patients with brachial access and 150 with femoral access. Access, procedural and fluoroscopy times were recorded. All patients were examined carefully immediately after the procedure and before discharge to assess any complications. Left brachial access was used more frequently than left femoral access (32.7% vs. 22.7%, P = 0.05), but no significant difference noted regarding right sided or bilateral access. Procedure time, fluoroscopy time, and contrast volume did not significantly differ (P = 0.19, 0.06 and 0.1 respectively). However, brachial group had shorter access time (2.6 ± 1.1 vs. 3.4 ± 0.7 min, P = 0.05) and hospital stay (3.5 ± 1.1 vs. 5.9 ± 1.3 days, P < 0.001). Regarding major and minor complications (especially hematomas), they were significantly less in the brachial arm (P = 0.04 and P = 0.05, respectively).

Conclusions
Brachial access is a safe, efficient and non-inferior to the femoral route for coronary intervention whenever radial access is not an option.
Impact of left ventricular hypertrophy on frequency and complexity of ventricular arrhythmia among hypertensive Egyptian patients
Authors: Abd El Azeem Ahmed Mokhtar , Abd Elmoneim Mohamed Ahmed , Rafla Samir Morkos , Youssif Gehan Magdy 
Published: March 2024

Abstract
Background
Left ventricular hypertrophy (LVH) is associated with an increased risk of ventricular arrhythmias and cardiovascular mortality. The study objective was to investigate the effect of LVH severity on the complexity and severity of ventricular arrhythmias among a subset of Egyptian hypertensive patients.

Results
The study cohort consisted of 60 hypertensive patients with LVH as diagnosed by echocardiography. Their mean age was (53.7 ± 12.3) years. 36 males (40%) and 24 females (60%). Diabetes mellitus was found in 26 patients (43%), 41% of these cases were smokers. 48-h Holter monitoring was performed in all cases to assess the frequency of ventricular premature contractions (VPC) and their complexity using the Lown grading. Increasing posterior wall thickness end diastole (PWTd) was an independent predictor of increasing VPC frequency, each 1 mm increase in the PWTd is associated with a 1.26% increase in the VPC% among total heart beats (b = 12.6, p < 0.001). Higher-grade VPCs—defined as grade 4a, 4b, and 5—were seen in 29 patients (48.3%). Interventricular septum thickness end diastole, PWTd, left ventricular mass, and left ventricular mass index (LVMI), were significantly higher among patients with higher Lown grading (p < 0.001). Using logistic regression analysis, female sex and LVMI were independent predictors of more complex VPC (OR = 8.766, p = .014), (OR = 1.096, p < 0.001), respectively. Among females, LVMI of more than 120 g/m2 can differentiate between high- and low-grade VPCs with 71% sensitivity and 80% specificity, while among males, LVMI of more than 129.5 g/m2 can differentiate between high and low-grade VPCs with 86% sensitivity and 66% specificity.

Conclusions
The frequency and complexity of ventricular arrhythmias among hypertensive heart disease are correlated with the severity of ventricular hypertrophy. Female sex and increasing left ventricular mass index are independent predictors of more complex forms of ventricular arrhythmias.
Digital breast tomosynthesis in the diagnostic settings of breast cancer patients treated by conservation therapy
Authors: Ahmed Shimaa Abdalla , Hassan Ramy A. , Makboul Marwa , Farghaly Shimaa , Khalaf Lamiaa M. R. 
Published: March 2024

Abstract
Background
Breast cancer survivors who underwent breast conserving therapy (BCT) are still 10% more likely to develop a second breast cancer at follow-up, Digital mammography (DM) was advised in every practical guideline for follow-up after BCT; however, it was difficult to distinguish between actual recurrence and scar development at DM.
Our research objective is to assess the value of Digital Breast Tomosynthesis (DBT) on the final Breast Imaging Reporting and Data System lexicon (BI-RADS) assessment categories compared to diagnostic digital mammography (DM) of breast cancer patients treated with breast conservation therapy (BCT), and to determine the additive value of DBT to DM or the use of DBT with synthetic 2D images in the diagnostic workup following BCT.

Results
Four hundred and seventeen breast cancer patients who underwent breast-conserving therapy (BCT) and received diagnostic assessments, including digital mammography (DM), digital breast tomosynthesis (DBT), and reconstructed synthetic 2D images, were enrolled in the study.
There is a significant reduction in the proportion of studies classified as probably benign BI-RADS 3 in synthetic 2D + DBT and DM + DBT compared with those in DM alone, and this was demonstrated by the two readers and at double reading (all P = 0.01). There is a significant increase in the PPV of malignancy in synthetic 2D + DBT and DM + DBT compared with those in DM alone for reader 2 (P = 0.01) and at double reading (P < 0.04) without a significant difference in the proportion of studies classified as BI-RADS category 4 or 5 for both readers and at double reading (p > 0.3).
Regarding the mammographic abnormalities, we noted a significant reduction in asymmetry and a significant increase in architectural distortion in synthetic 2D + DBT and DM + DBT compared with those in DM alone, and this was demonstrated by the two readers and at double reading (all P = 0.01).

Conclusions
The addition of digital breast tomosynthesis (DBT) into the diagnostic process after breast-conserving therapy (BCT), either in conjunction with digital mammography (DM) or with synthetic 2D images in the diagnostic workup following BCT, significantly decreases the proportion of studies classified as probably benign, significantly increases the rate of studies classified as normal or benign, and significantly increase in the positive predictive value (PPV) of malignancy without significant difference in the patients classified as BI-RADS category 4 or 5. Moreover it improved diagnostic confidence in biopsy recommendations, regardless of mammographic density.
Computerized constructed wetlands allocation model (based on ecosystem services demand)
Authors: Mohamed Nouran Moustafa , Al-Attar Abdullah Farouk , Lotfi Yomna Amr , El-Barmelgy Hesham Mohamed 
Published: March 2024

AbstractEgypt’s urban communities face many threats, including, pluvial floods, heat waves, and lack of publicly accessible urban green spaces. Nature-based solutions such as constructed wetlands (CWs) present a promising solution that could offer a wide range of ecosystem services (ES). However, the adoption of CWs is challenged by the lack of local planning guides and uncertainty about potential benefits. There are various models and tools available for quantifying and valuing ES, however, many of them are either highly complex or require extensive data and expertise. The aim of this paper is to develop a GIS-based multi-criteria decision model to select CW sites based on the supply and demand of ES. The model is to operate on three main stages: (i) demand: based on the need for risk reduction or benefit provisioning, (ii) potential sites (PSs): identify and score suitable sites for establishing a CW, and (iii) supply: define the service benefiting areas (SBA). An experimental approach is used, where the model is tested on New Damietta, an Egyptian Mediterranean city, proving the model is a reliable decision-making tool during preliminary urban planning stages due to its practicality, flexibility, and reasonable data requirements.
Transwar Japanese Thought at “the End of Ideology”
Authors: Hurley Brian 
Published: March 2024

Abstract
In 1957, the Japanese affiliate of the Congress for Cultural Freedom, an international anticommunist organization dedicated to the liberal ideals of the “free world,” convened a symposium under the title “Tradition and Transition in Japanese Culture” (“Nihon bunka no dentō to hensen”). The event put noted Kyoto School intellectuals who had earlier conceptualized Japan's unique mission within world history during the war years—including Kōsaka Masaaki, Suzuki Shigetaka, and Nishitani Keiji—into dialogue with postwar thinkers who advocated for freedom of thought in opposition to what they viewed as the closed-mindedness of ideology. Drawing on rarely cited archival documents, this article explores how the symposium raised key questions about the fate of world historical thinking in transwar Japan at the same time that it tested the putative universality of postwar liberal ideals against what the symposium participants called the particularity of Japanese culture.