bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost‐Effectiveness of Telavancin versus Vancomycin for Treatment of Complicated Skin and Skin Structure Infections
Authors: Laohavaleeson Somvadee , Barriere Steven L. , Nicolau David P. , Kuti Joseph L. 
Published: November 2008

Study Objective. To determine the cost‐effectiveness of telavancin versus vancomycin for the treatment of complicated skin and skin structure infections (cSSSIs).Design. Pharmacoeconomic analysis conducted from the hospital's perspective using data from the Assessment of Telavancin in Complicated Skin and Skin Structure Infections (ATLAS) phase III clinical trial.Setting. One hundred twenty‐nine hospitals in the United States and internationally.Patients. A total of 1044 clinically evaluable patients who were hospitalized with a cSSSI during the ATLAS trial and who received at least one dose of telavancin or vancomycin in the hospital.Measurements and Main Results. Diagnosis‐related group‐specific hospital bed costs, antibiotic acquisition prices, and cost of vancomycin monitoring were applied to the resource utilization data collected during the ATLAS trial. Infection‐related length of stay (LOSIR) and hospitalization costs (COSTIR) were compared between the telavancin (514 patients) and vancomycin (530 patients) groups. Incremental cost‐effectiveness ratios (ICERs) were calculated for the total population and a subset of patients infected with methicillin‐resistant Staphylococcus aureus (MRSA) by using a 25,000‐sample bootstrap analysis. During sensitivity analyses, the daily acquisition price for telavancin was increased from the equivalent to vancomycin ($13.44) to $50, $100, $150, or $200, and the rate of MRSA acquisition was varied between 30% and 75%. The median (interquartile range) LOSIR was 8 days (6–12 days) for both telavancin and vancomycin (p=0.742), and median (interquartile range) COSTIR was $8118 ($6291‐11,758) and $8185 ($6474‐11,405), respectively (p=0.560). Similar findings were observed for the MRSA subset. Telavancin cost‐effectiveness was greater for the MRSA population versus the total population. During bootstrap analyses of the MRSA population, the ICER for telavancin ranged from dominant (‐$9560) to $27,889 as acquisition price was increased.Conclusions. Telavancin LOSIR and total COSTIR were similar to those of vancomycin for the treatment of cSSSIs. Particularly in those infected with MRSA, telavancin may be more cost‐effective than vancomycin over the range of acquisition prices tested.
Association of the HistamineN‐Methyltransferase C314T (Thr105Ile) Polymorphism with Atopic Dermatitis in Caucasian Children
Authors: Kennedy Mary Jayne , Loehle Jennifer A. , Griffin Angela R. , Doll Mark A. , Kearns Gregory L. , Sullivan Janice E. , Hein David W. 
Published: November 2008

Study Objective.To investigate potential associations between the histamineN‐methyltransferase (HNMT) gene,HNMT, C314T (Thr105Ile) polymorphism and atopic dermatitis in a cohort of Caucasian children.Design.Prospective, multicenter, genotype‐association study.Setting.Four academic, tertiary care medical centers within the Pediatric Pharmacology Research Unit network.Participants.Two hundred forty‐nine Caucasian children aged 6 months‐5 years with atopic dermatitis (127 patients) or without (122 control subjects).Intervention.Buccal swabs (one swab/cheek) were performed to obtain epithelial cells for extraction of genomic DNA.Measurements and Main Results.Data were collected on severity of atopic dermatitis, oral antihistamine treatment, and treatment response through parental report. TheHNMTgenotypes were successfully obtained in 116 control subjects and 122 patients with atopic dermatitis. Frequencies of the T314 variant allele (0.12 vs 0.06, p=0.04) and combined CT/TT genotype (0.24 vs 0.12, p=0.02) were significantly higher in children with atopic dermatitis compared with control subjects. Children with genotypes conferring reduced HNMT activity were 2 times more likely to have atopic dermatitis than those who were homozygous for the C314 reference allele.Conclusion.Increased histamine levels in patients with atopic dermatitis may result, at least in part, from reduced enzymatic inactivation via HNMT. Genetically associated reduction in histamine biotransformation may therefore contribute to the pathogenesis, persistence, and progression of atopic dermatitis. If confirmed, these data indicate thatHNMTgenotype might represent a common risk factor for development of atopic dermatitis, asthma, and allergic rhinitis and may be useful in identifying individuals who are candidates for early preventive pharmacotherapeutic intervention. Additional longitudinal studies will be required to assess the relationship between genotype, disease severity, and antihistamine response.
Anophthalmia, Cleft Lip/Palate, Absent Vomer Bone, Nystagmus, and Mental-Motor Retardation: A New Syndrome or Fryns“Anophthalmia-Plus” Syndrome?
Authors: Özçelik Derya , Sağlam İbrahim , Sılan Fatma , Sezen Gülbin , Ünveren Toygar 
Published: November 2008

Objective: We report that a 4-year-old boy presented with right unilateral complete cleft lip and palate, right anophthalmos, left congenital nystagmus, absence of the vomer bone, mental-motor retardation, and normal lymphocyte karyotype (46, XY). Methods: For reconstruction of the deformities, we performed cleft lip repair by Millard's rotation-advancement technique and planned cleft palate repair. Conclusions: This combination of cleft lip and palate, anophthalmos, congenital nystagmus, absent vomer bone, and mental-motor retardation has not, to our knowledge, previously been described. We suggest that this represents either another case of the rare Fryns “anophthalmia-plus” syndrome or a new syndrome.
Investigations of operational driving loads of bucket chains and manoeuvre hoisting winches on multi-bucket dredgers
Authors: Bocheński Damian 
Published: November 2008

Investigations of operational driving loads of bucket chains and manoeuvre hoisting winches on multi-bucket dredgers
The paper concerns problems of preliminary designing of bucket dredgers' power plants. This paper presents results of investigations of six bucket dredgers in service. The operational investigations consisted in measuring the parameters which characterize working conditions of two main receivers of mechanical energy: bucket chains and swing winches. In the paper characteristics of disposition of loading of bucket chains and swing winches are presented. They covered average value, standard deviation and coefficient of variance of loading disposition mutability. Examples of load distributions of chains' and group of swing winches on chosen dredgers during some period of time were given. Conclusions in view to average values of main receivers of mechanical energy and coefficients of variance of loadings spred were formulated. Results of investigations of dependence of average loadings of main receivers on their nominal power were presented. The results of work will be used in creation of random models describing real conditions of operation of power plant elements of dredgers.
The Effect of Stressor Level Grading on the Stimulus Seeking Behavior of Rats Differing in Emotional Reactivity1
Authors: Farley Dominika , Matysiak Jan 
Published: November 2008

The Effect of Stressor Level Grading on the Stimulus Seeking Behavior of Rats Differing in Emotional Reactivity1
A natural disaster — such as a flood — is a sequence of events: swollen water level leading to the flooding of homesteads — primary stressor and later environmental consequences — secondary stressor syndrome. In order to be valid, an experimental model must ensure similarity of the stress-evoked behavioral symptoms. The most frequently administered behavioral tests measure exploratory behavior in the broad sense (we used the following test battery: self-exposition chamber, open field and elevated cross-maze). We also included emotional reactivity in the experimental design in order to test the idea that lower emotional reactivity alleviates the consequences of stress and therefore acts preventively. Reduced emotional reactivity and increased stressor intensity additively contribute to increased exploratory behavior. A main handling effect is found for most indices of emotional behavior. The proposed experimental model seems to meet two important criteria: it has face validity and it evokes very clear behavioral consequences, ones which are universal for most indices of exploratory behavior
Validating a Markov Model of Treatment for Hepatitis C Virus-related Hepatocellular Carcinoma
Authors: Wong J.B. , Hino K. , Kurokawa F. , Nishina S. , Sakaida I. , Okita K. , Tamesa T. , Oka M. , Torimura T. , Sata M. , Takahash S. , Chayama K. , Inoue Y. , Ishida H. 
Published: November 2008

Summary

Objective:
We created and validated a Markov model to simulate the prognosis with treatment for HCV-related hepatocellular carcinoma (HCC) for assessment of cost-effectiveness for alternative treatments of HCC.

Method:
Markov state incorporated into the model consisted of the treatment as a surrogate for HCC stage and underlying liver function. Retrospective data of 793 patients from three university hospitals were used to determine Kaplan-Meier survival curves for each treatment and transition probabilities were derived from them.

Results:
There was substantial overlap in the 95% CIs of the Markov model predicted and the Kaplan-Meier survival curves for each therapy. The predicted survival curves were also similar with those from the nationwide survey data supporting the external validity of our model.

Conclusions:
Our Markov model estimates for prognosis with HCC have both internal and external validity and should be considered applicable for estimating cost-effectiveness related to HCC.
Nonlinear modeling of protein separation in a preparative‐scale dynamic field gradient focusing instrument
Authors: Tracy Noah I. , Ivory Cornelius F. 
Published: November 2008

AbstractDynamic field gradient focusing (DFGF) uses an electric field gradient opposed by a counter‐flow of buffer to separate milligrams of proteins according to their electrophoretic mobilities. A nonlinear model of protein separation in a preparative‐scale DFGF device was developed to aid in refining the instrument's design and finding optimal run conditions prior to performing experiments. The model predicted the focal points of bovine serum albumin (BSA), and bovine hemoglobin (Hb) to within the 95% confidence intervals about the means of the experimental values. The resolution between the proteins in the model was 2.08, which was 3% less than the lower limit of the 95% confidence interval about the experimental value. The model predicted 67% more dispersion than was present in the experimental device, which made the simulated BSA peak 22% wider than the experimentally measured width. © 2008 American Institute of Chemical Engineers AIChE J, 2009
Salivary cortisol and psychosocial hazards at work
Authors: Maina Giovanni , Palmas Antonio , Bovenzi Massimo , Filon Francesca Larese 
Published: November 2008

AbstractBackgroundExperimental and clinical evidence suggest that stress can lead to ill‐health through the disregulation of the hypothalamic–pituitary–adrenal (HPA) axis. Studies to date have produced equivocal results likely due to different methodologies and failure to account for confounding factors. This investigation aimed to assess the relation between self‐reported work‐related stressors and salivary cortisol and to clarify the role of the potential confounders.MethodsThirty‐six call‐handlers completed a self‐administered job content questionnaire and collected seven daily salivary samples on two workdays and a weekend. The diurnal salivary cortisol output was expressed as cortisol awakening response (CAR), and cortisol output in the rest of the day. Salivary cortisol data were normalized by means of square root transformation. The generalized estimating equations method was used to assess the relation between job strain and cortisol levels after adjusting for gender, weekdays and adherence to the sampling schedule.ResultsJob strain significantly influenced the total amount of cortisol response to waking (high strain vs. low strain: 1.1 (0.3–2.0) nmol/L). The cortisol response to waking showed gender‐specific differences [women excreting greater cortisol than men: 1.1 (0.3–1.9) nmol/L], and weekday differences [workdays vs. weekend: 1.0 (0.3–1.6) nmol/L]. Non‐compliance with the sampling protocol was associated with lower salivary cortisol than in adherent subjects.ConclusionsOur results provide further evidence for the HPA axis involvement in the physiological response to work stress. The measure of the CAR showed to be the sensitive index to assess the physiological response to psychosocial factors. Gender, weekday, and protocol compliance were confounding factors. Am. J. Ind. Med. 52:251–260, 2009. © 2008 Wiley‐Liss, Inc.
Electromyographic activity and thickness of masticatory muscles in children with unilateral posterior crossbite
Authors: Andrade A.S. , Gavião Maria B.D. , DeRossi M. , Gameiro G.H. 
Published: November 2008

AbstractThe aim of this study was to assess the electromyographic (EMG) activity and thickness of the masseter and anterior temporalis muscles in children with unilateral posterior crossbite (PCB). Thirty‐six children (22 boys, 14 girls, and mean age of 8.8 ± 1.1 years) were divided into the following groups: The case group with 20 PCB patients (10 on the left side, 10 on the right side); the control group with 16 normal occlusion (NOccl) subjects. EMG activity was recorded with bipolar surface electrodes at rest and during maximal clenching. The muscle thickness was measured with real‐time ultrasound. Data were compared between groups and between sides. The correlation between EMG activity and muscle thickness was also evaluated. The data were analyzed using the Shapiro‐Wilks test, Pearson's correlation and Spearman as appropriate, paired and unpaired t‐ test, and Mann‐Whitney test. The results revealed that the masseter of the crossbite side was more active than that of the non‐crossbite side in PCB group during maximal clenching. The comparisons of EMG activity between PCB and NOccl groups revealed some variability in the results, depending on the crossbite side. The ultrasonographic evaluation did not show statistically significant differences between groups, nor between sides in the PCB and NOccl groups. Significant correlation between EMG activity and thickness was observed only in the left masseter in the NOccl group. In conclusion, these findings showed that asymmetric muscle activity of the masticatory muscles was not related to the thickness of these muscles in children with PCB. Clin. Anat. 22:200–206, 2009. © 2008 Wiley‐Liss, Inc.
Student views on the introduction of anatomy teaching packages into clinical attachments
Authors: Dawson A. G. , Bruce S. A. M. , Heys S. D. , Stewart I. J. 
Published: November 2008

AbstractFollowing the implementation of the GMC document Tomorrow's Doctors in 1993 the amount of time dedicated to anatomy in undergraduate curricula has been reduced. This has resulted in considerable disquiet among physicians and surgeons with regard to the anatomical knowledge of newly qualified doctors, and also amongst students. This study aimed to assess the perceived student need for anatomical teaching packages to support clinical attachments in the later years of the undergraduate medical curriculum. The views of two groups of students were obtained: Group A were at the beginning of their clinical attachments, whereas Group B had completed all clinical attachments and had sat the final examination. The majority of students indicated that there was a need for the development of a teaching package for anatomy (and other basic sciences) in the later stages of the undergraduate medical curriculum. A high proportion stated that the completion of these packages should be in a self‐directed manner with a staff member available. There was a difference between both groups in response to the best time to offer the packages, and in the clinical areas which might be prioritized in such a development. We conclude that the vertical integration of anatomy—perhaps through clinically focused teaching packages—would be welcomed by students as part of their clinical attachments. Clin. Anat. 22:267–272, 2009. © 2008 Wiley‐Liss, Inc.
ChemInform Abstract: 1/∞[ZrPSe6‐]: A Soluble Photoluminescent Inorganic Polymer and Strong Second Harmonic Generation Response of Its Alkali Salts.
Authors: Banerjee Santanu , Malliakas Christos D. , Jang Joon I. , Ketterson John B. , Kanatzidis Mercouri G. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Spectroscopic Study of YBa3B9O18, an Interesting Material Containing a Six‐Membered Borate Ring.
Authors: Baran Enrique J. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Thermal Dissociation of Molten KHSO4: Temperature Dependence of Raman Spectra and Thermodynamics.
Authors: Knudsen Christian B. , Kalampounias Angelos G. , Fehrmann Rasmus , Boghosian Soghomon 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Subsolidus Phase Relations of the SrO—MO2—CuO Systems (M: Ti, Zr and Hf) at 900 °C in Air.
Authors: Grivel J.‐C. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Platinum/Mesoporous WO3 as a Carbon‐Free Electrocatalyst with Enhanced Electrochemical Activity for Methanol Oxidation.
Authors: Cui Xiangzhi , Shi Jianlin , Chen Hangrong , Zhang Lingxia , Guo Limin , Gao Jianhua , Li Jingbo 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Uniform Metal (Hydr)Oxide Particles from Water/Ionic Liquid Precursor (ILP) Mixtures.
Authors: Li Zhonghao , Rabu Pierre , Strauch Peter , Mantion Alexandre , Taubert Andreas 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: In situ Observation of the Formation of Si Clathrate Ba8Si46 at High Pressure and High Temperatures.
Authors: Imai Motoharu , Kikegawa Takumi 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cationic Main‐Group Metal Chalcogenide with a 1‐D Polymeric Structure, [{In(dien)}2(InTe4)]×Cl.
Authors: Li Chun‐Ying , Chen Xiao‐Xia , Zhou Jian , Zhu Qin‐Yu , Lei Zhi‐Xin , Zhang Yong , Dai Jie 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthetic Approaches for Noncentrosymmetric Molybdates.
Authors: Hubbard Desmond J. , Johnston Alexander R. , Casalongue Hernan Sanchez , Sarjeant Amy Narducci , Norquist Alexander J. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydrothermal Synthesis of Vanadium Oxyfluoride Chains Incorporating Covalently Bound Copper Coordination Complexes.
Authors: Mahenthirarajah Thushitha , Li Yang , Lightfoot Philip 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Rhodium‐Catalyzed 1,4‐Additions of 2‐Heteroarylzinc Donors Using Me‐DUPHOS.
Authors: Le Notre Jerome , Allen Joseph C. , Frost Christopher G. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Organocatalytic Michael Additions to Acrylic Acid Derivatives: Generation of All‐Carbon Quaternary Stereocenters.
Authors: Rigby Caroline L. , Dixon Darren J. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Novel Chiral Tridentate Aminophenol Ligands for Enantioselective Addition of Diethylzinc to Aldehydes.
Authors: Yang Xiao‐Feng , Hirose Takuji , Zhang Guang‐You 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Michael Reactions of β‐Ketoesters Catalyzed by Yb(NTf2)3 in the Presence of Water.
Authors: Suzuki Ichiro , Suzumura Yuko , Takeda Kei 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.