bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of TSH stimulation on serum thyroglobulin in metastatic thyroid cancer
Authors: Gerfo Paul Lo , Colacchio Thomas A. , Colacchio Donald A. , Feind Carl R. 
Published: February 2007

AbstractThyroglobulin (TG) is a glycoprotein which has been found to be produced by almost all nonmedullary thyroid cancers, and is present in elevated levels in the serum of most patients with metastatic thyroid cancer. It has long been a clinical impression that many metastatic thyroid cancers are “responsive” to TSH suppression as manifested by a decrease in the size and/or symptoms of the tumor. Five athyroid patients with metastatic thyroid cancer were studied to determine the effect of TSH stimulation on their serum TG levels and attempt to correlate this effect with their clinical response. Three of the five patients showed a definite rise in their serum TG once serum thyroxine (T4) replacement was withdrawn, which correlated with an increase in TSH, and two of these patients have had no progression of their disease while on T4 suppression. The remaining two patients have shown no change in their TG levels after T4 withdrawal, and both have had progression of their metastatic disease while on T4 suppression. Thus, we see that in some patients, TG production by their metastatic thyroid cancer is responsive to TSH suppression, and there is some suggestion that TSH‐responsive cancers are less aggressive; but it will require further studies to determine this.
Nonspecific immunosuppression by cultured lymphocyte supernates of cancer patients
Authors: Svedsersky Lloyd P. , Minton John P. , Kolodziej Bruno J. 
Published: February 2007

AbstractA nonspecific immunosuppressive factor, lymphocyte immunosuppressive substance (LIS), has been correlated with cancer patients. Significant suppression of IgM antibody production of sheep erythrocyte immune Swiss mice lymphocytes was found when the immune lymphocytes were treated with cultured peripheral blood lymphocyte supernates of tumor‐bearing patients. A lesser amount of LIS activity was also demonstrated with patients who had cancer in the past, but were clinically free of disease at the time of testing. This suppressive activity has been demonstrated with several solid tumors including breast CA, colon CA, melanoma, uterine CA, and ovarian CA. A possible use of this suppression test for detecting recurrences is suggested from the data.
Liposarcomas: Prognosis and management
Authors: Celik C. , Karakousis C. P. , Moore R. , Holyoke E. D. 
Published: February 2007

AbstractFifty‐one evaluable patients with liposarcomas were reviewed. Two‐thirds of the patients were referred after local recurrence. One‐third with primary surgery at RPMI had local recurrence rate of 31.6%. Overall, one or more local recurrences presented in 78% of patients. Pulmonary metastases occurred in 45%, while liver metastases in 13.6%.Most common primary sites were the lower extremity, followed by the retroperitoneal area and upper extremity.Median survival is better for upper and lower extremities than other areas (P < 0.01). The median survival was longer in the group that received radiation after resection although the difference was not statistically significant. The high rate of local recurrences suggests the adjuvant use of radiation postoperatively when the surgical margins have not been adequate.Sixteen patients are alive and disease‐free, with 10 of them having had five years or longer follow‐up.
Squamous cell carcinoma of the pancreas
Authors: Sears Henry F. , Kim Young , Strawitz Joseph 
Published: February 2007

AbstractEpidermoid cancer of the panceras is a rare variety of this malignancy. A case is presented. It has a characteristic angiographic appearance. Though in the past it has had a prognosis similar to the more common adenocarcinoma of the pancreas, a chemotherapeutic agent effective against epidermoid tumors at other sites has been effective in a case reported in the recent cancer treatment literature.
Macrophage activation and mobilization in nude mice by corynebacterium parvum and pyran: A functional and histologic study
Authors: Stinnett J. D. , Majeski J. A. 
Published: February 2007

AbstractPeritoneal macrophages from both congenitally athymic (“nude”) mice and heterozygous littermates were activated by pyran copolymer or by Corynebacterium parvum vaccine. C parvum did not produce an increase in the number of peritoneal macrophages in nude mice, although it did produce a typical splenomegaly. Pyran produced an even greater influx of macrophages in the peritoneum of nude mice, when compared to normal mice, but did not produce splenomegaly in nude mice. Pyran‐ and C parvum‐induced splenomegaly were accompanied by an increase in the apparent T‐cell population of germinal centers. These experiments indicate that: 1) Macrophage activation, perse, by either C parvum or pyran, is a thymus‐independent event; 2) Macrophage mobilization, as determined by organomegaly or PEC number, does not have an obligatory requirement for T‐cells (depending on the agent used); 3) Macrophage activation may not always correlate with mobilization; and 4) Mechanisms for attracting and sequestering macrophages in the peritoneum may be different from those of the spleen.
Metachronous primary carcinoma of small bowel following resected colorectal carcinoma: A report of three cases
Authors: Honoré Louis H. 
Published: February 2007

AbstractThree cases of metachronous adenocarcinoma of the large and small bowel are reported. The small‐bowel lesions were not even suspected properatively and were diagnosed after extensive pathologic study. Though rare, metachronous primary carcinoma of the small bowel must be considered in a patient with intestinal obstruction or hemorrhage following colorectal cancer surgery. Preoperative diagnosis, which demands a high index of suspicion and careful technical evaluation, is crucial in determining the overall surgical management of the patient.
Influence of vasoactive drugs on blood flow in subcutaneous tumors – an experimental study in rats
Authors: Hafström Larsolof , Persson Bertil , Sundqvist Kaj 
Published: February 2007

AbstractSubcutaneously implanted tumors in Wistar and Lister rats were used as a model for the study of metastatic tumor blood flow and how it is affected by vasoactive drugs. Blood flow measurements were obtained using the labelled microsphere method and the reference organ technique. Microspheres (15‐μm) labelled with either 99Tcm or 51 Cr isotopes were injected intracardially and a reference sample was drawn simultaneously at constant speed. This was performed before and after the infusion of vasoactive drugs, and (as control), saline infusion. The drugs tested (adrenaline, noradrenaline, glucagon, histamine, and vasopressin) showed profound effects on central hemodynamic parameters and on muscle and skin blood flow. The relative tumor blood flow, measured as the ratio between tumor and skin or tumor and muscle blood flow, was calculated. The results show that no enhancement of the relative tumor blood flow could be registered. In fact, a decrease in the tumor‐to‐muscle‐blood‐flow ratio was noted when noradrenaline was infused, and in the tumor‐to‐skin ratio when adrenaline was infused. Blood flow in subcutaneous tumors was four to five times that in muscle or skin. Tumor blood flow was also inversely related to the size of the tumor.
The role of hepatic artery ligation and dearterialization with infusion chemotherapy in advanced malignancies in the liver
Authors: Berjian R. A. , Douglass H. O. , Nava H. R. , Karakousis C. 
Published: February 2007

AbstractBecause of limited benefits derived with the use of systemic chemotherapy, 15 patients with metastatic malignancy of the liver or hepatoma were treated by hepatic artery ligation [6] or dearterialization [9] and regional infusion chemotherapy.There were two post operative deaths and three patients required surgical drainage of hepatic tumor liquefaction necrosis. The median survival was 14 months with two patients still living. The longest survivors were those patients with visceral leiomyosarcoma or carcinoid tumor. Five of the patients had failed to respond to previous chemotherapy, all showed a favorable response to this therapy.Rigid criteria for proper case selection have been developed which should reduce the operative mortality. Hepatic artery ligation is a therapeutic modality that can be of benefit to patients for whom no other satisfactory treatment is available.
Anaplastic thyroid carcinoma: Long‐term survival after radical surgery
Authors: Goldman Joel M. , Goren Elihu N. , Cohen Max H. , Webber Bruce L. , Brennan Murray F. , Robbins Jacob 
Published: February 2007

AbstractAnaplastic carcinoma of the thyroid is a highly malignant disease with few survivors over one year. Radical surgery and laryngectomy are usually considered contraindicated. A 50‐year‐old woman with a history of papillary carcinoma treated with external radiation developed anaplastic giant‐cell carcinoma of the thyroid invading the soft tissues of the neck including the larynx. Since surgery was felt to represent her only chance for survival, she underwent laryngopharyngectomy, right radical‐neck dissection, and pharyngeal reconstruction. Three years after the surgery was performed, she is living an active life with only minor handicaps. Nevertheless, multiple nodules were noted in her lungs on recent tomographic examination. Our experience with this woman suggests that there is a role for radical surgery and laryngectomy in selected cases of anaplastic carcinoma.
A comparative study of breast cancer in the black and white populations of two inner‐city hospitals
Authors: Mittra Nirmal K. , Rush Benjamin F. , Verner E. 
Published: February 2007

AbstractA comparative study of breast cancer was made among black and white populations admitted to two inner‐city hospitals from 1971 through 1976, inclusive. There were 306 patients in the study group of which 162 were black and 144 were white. Age, sex, color, duration of illness, different quadrants of breast involved, staging of cancer, histological diagnosis, treatment given, and incidence of recurrence were studied in each group. A statistically higher incidence of cancer of the breast was found among the black patients in the groups aged 30–50 years and 70–80 years, as compared to the white population. All other parameters studied showed no statistical differences.
Palliative prosthetic intubation in gastric cancer
Authors: Turnbull A. , Kussin S. , Kurtz R. C. , Bains M. 
Published: February 2007

AbstractObstruction to swallowing from recurrent gastric cancer following total gastrectomy or when the tumor is initially unresectable presents a major surgical challenge. Resection of the recurrence or various bypass procedures are indicated, when technically feasible, unless widespread metastases are found. A useful palliative approach for obstructed patients with a limited prognosis is the use of a Celestin endoesophageal tube. This report describes the indications for and method of insertion in two typical clinical situations. Anchoring the tube to the anterior abdominal wall prevents proximal migration of the prosthesis, a complication which occurred six months later in a patient in whom this was not possible.
Chemical and hematological screening in patients with malignant and non‐malignant conditions
Authors: Lee Yeu‐Tsu N. , Van Peenen Hubert J. , Watson Francis R. 
Published: February 2007

AbstractThe value of multiphasic automated laboratory tests in differentiating stages of malignancy and in detecting recurrence of cancer was studied. Chemical SMA‐12 tests (including calcium, phosphate, glucose, BUN, uric acid, cholesterol, total protein, albumin, total bilirubin, alkaline phosphatase (AP), lactic dehydrogenase (LDH) and SGOT) and hematological SMA‐4 tests (including hematocrit, hemoglobin, WBC and RBC counts) were performed in 1,578 patients. Baseline data obtained from 582 patients with benign, and 996 patients with malignant, lesions were subdivided according to age, sex, primary site, and extent of cancer. With advancing stages of cancer, there was a significant increase of AP and LDH, but decrease of albumin and hemoglobin. Among patients who had sequential tests, there was a significant decrease of uric acid and LDH with control of cancer, and increase of AP with development of distant dissemination.
Indomethacin and ascorbate inhibit desmoid tumors
Authors: Waddell William R. , Gerner Robert E. 
Published: February 2007

AbstractAdministration of indomethacin caused complete resolution of a desmoid tumor after a partial response to radiation. In another patient, this drug caused an immediate response, then became ineffective. When large doses of ascorbic acid were given with indomethacin, slow resolution of the tumor began and has continued for 14 months. Treatment of a third case with indomethacin and ascorbic acid from the beginning produced shrinkage of the tumor which has continued to date.
Diagnosis of hepatoma by scintigraphy using multiple radionuclides
Authors: Lee Victor W. , Estabaya Eli , Shapiro Jerome H. 
Published: February 2007

AbstractThe conventional liver scan, using 99mTC‐sulfur colloid, is very sensitive in detecting focal abnormalities, but it is nonspecific, since most lesions appear as “cold” defects. Liver scan can be much more specific if the right combination of the many available radiopharaceuticals is used. This fact is exemplified by our case report of hepatoma. All scans can be done noninvasively, with low radiation exposure to the patients.
Malignant mesotheliomas and chemotherapy
Authors: Karakousis C. P. , Seddiq M. , Moore R. 
Published: February 2007

AbstractOf 77 patients with mesotheliomas, 63.6% had pleural involvement, 31.2% had peritoneal involvement, and 5.2% had involvement at other sites. The presenting symptoms varied with the location of the primary. Surgery and irradiation did not appear to influence the course of the diffuse type. Of 41 patients given systemic chemotherapy, three patients had complete response and four had greater than 50% objective response (median survival 42.5 months); 18 patients had stabilization (median 12.8 months), and 16 showed no response (median 4.5 months). The difference in survival between responders and non‐responders was statistically significant (P < 0.001). Of 16 patients who received secondary chemotherapy, four had complete response (median survival 17.5 months), six had stabilization (median 10.5 months), and six had no response (median 2.5 months). Chemotherapy appears moderately effective in the treatment of mesotheliomas.
Bipedicle transverse abdominal cutaneofascial flap for reconstruction of lower thoracic wall defects
Authors: Auda Stephen P. , Sindelar William F. W 
Published: February 2007

AbstractA simple reliable technique for reconstruction of low‐lying anterior thoracic wall defects following trauma or excision of neoplasms is illustrated by a case presentation and described. The bipedicle transverse abdominal cutaneofascial flap is based on the lateral cutaneous branches of the lower intercostal arteries, which offer an excellent blood supply allowing it to be raised and used even in the presence of radiated tissue. The potentials and contraindications for employing this flap are presented. The simplicity with which this flap can be raised and applied should make the general surgeon consider its use when indicated.
Bronchial malignant melanoma
Authors: Weshler Zeev , Sulkes Aaron , Kopolovitch Juri , Leviatan Avigdor , Shifrin Edward 
Published: February 2007

AbstractWe describe a case of malignant melanoma presenting initially as an endobronchial lesion located in the left main bronchus causing total atelectasis. This resolved with radiation therapy. Widespread metastases developed shortly thereafter.The differential diagnosis of primary and metastatic bronchial malignant melanoma is discussed. Other isolated case reports are reviewed.
The immune response to prostate cancer: An evaluation and a review
Authors: Guinan P. , Bhatti R. , Sharifi R. , Sundar B. , Nagubadi S. , Baumgartner G. 
Published: February 2007

AbstractThe effects of stage and therapy of prostate cancer on the immune response were evaluated in 193 patients with an histologic diagnosis of prostatic malignancy. There was little or no effect, as measured by these generally nonspecific tests, on the immune response. The host‐tumor immune interaction is difficult to evaluate in prostate cancer. The complexities of measuring prostate tumor immunity are discussed and the literature is reviewed.
Suppressive effects of thiopental and halothane on specific arms of the immune response
Authors: Lovett Edmund J. , Alderman James , Munster Edward , Lundy Joel 
Published: February 2007

AbstractThe effect of thiopental, halothane and surgery on specific arms of the immune response of normal mice was studied. These experiments represent the first step in localizing a potentially correctable anesthesia/surgery‐induced defect in immune reactivity which may be involved with postoperative increases in tumor growth. The delayed‐type hypersensitivity (DTH) response of mice to 2,4‐dinitrochlorobenzene (DNCB) was studied. Combinations of induction and inhalation anesthesia and surgery were administered at various phases of the immune response to DNCB. Thiopental impaired the afferent response while halothane impaired the efferent response. When the agents were combined, both arms of the immune response were suppressed. A surgical procedure, in most experiments, did not produce a greater immunosuppression than thiopental and halothane. The administration of an immunorestorative agent, thiabendazole, returned reactivity to normal levels. Thiopental and halothane either affect different immune cell populations or they affect different functions of a cell population active in both arms of the DTH response. In relation to tumor growth, the degree of suppression may not be as significant as the cell population impaired.
Primary malignant mediastinal germ cell tumors: A study of three cases
Authors: Dosios T. , Sbokos C. , McMillan I. K. R. , Mitchell J. , Floros D. 
Published: February 2007

AbstractThree patients with primary malignant mediastinal germ cell tumors are presented and the literature is briefly reviewed. A great disparity exists in the literature regarding the classification and differential diagnosis of these tumors. Resection and irradiation of seminomas give relatively satisfactory results. The prognosis of malignant teratomas, embryonal cell carcinomas and choriocarcinomas is poor, regardless of the mode of treatment.
Serum zinc, serum copper, and the Cu/Zn ratio in patients with epidermoid cancers of the head and neck
Authors: Garofalo J. A. , Erlandson E. , Strong E. W. , Lesser M. , Gerold F. , Spiro R. , Schwartz M. , Good R. A. 
Published: February 2007

AbstractSerum zinc levels (SZL), serum copper levels (SCL), and the Cu/Zn ratio were evaluated in 50 patients with epidermoid cancer of the head and neck to treatment with respect to site and stage of disease. There was no significant difference in these parameters compared to healthy normal controls.We could not appreciate any diagnostic or prognostic value in these parameters in patients with head and neck cancer. There was, however, a sex‐related difference for SZL in men with oral cavity and women with laryngeal lesions, and a trend toward decreasing SZL and increasing SCL and the Cu/Zn ratio with advanced stage of disease.
Evaluation of whole blood catalase estimation for diagnosis of malignancy
Authors: Fitzpatrick John , Bhargava Arvind , Bedwani Ramez , Gagnon Marcel 
Published: February 2007

AbstractWhole blood catalase levels were estimated using a disc flotation method in 209 random patients with a wide variety of malignancies. Fifty patients had received no treatment, and the remainder, although having undergone prior therapy, had recurrent or metastatic disease at the time of the study. No relationship was found between the presence of cancer and catalase levels. A direct relationship was found for catalase with hemoglobin levels in both normal and patients' samples. Whole blood catalase is of no value in diagnosis and monitoring of cancer. The decreased catalase values found here and reported previously by others are the result of low hemoglobin levels found in many patients with cancer.
Primary oat cell carcinoma of the larynx: A case history and literature review
Authors: Jose Baby , Conley Joe G. , Tobin Daniel A. , Dorman David W. 
Published: February 2007

AbstractA case of primary oat cell carcinoma of the larynx is described and the literature reviewed. The origin of this rare tumor and the natural history of the disease are discussed. The different treatment modalities carried out so far are described.
A clinicopathological study of primary gastrointestinal lymphoma
Authors: Gupta Saroj , Pant Girish C. , Gupta Saroj 
Published: February 2007

AbstractA retrospective analysis of 48 cases of histologically proven primary gastrointestinal lymphoma was done. The analysis covered a 12‐year period from January 1966 through December 1977. Four percent of all malignant tumors of the gastrointestinal tract were of this type. Males outnumbered females by a ratio of 1.8:1. The mean age of the patients was 21 years. The vagueness and variability of clinical features and nonspecific radiological findings were the main reasons for subjecting all the patients in this series to laparotomy. The most common site of involvement was the ileocecal region, followed by the ileum, the jejunum, and the stomach. Most of the cases were in an advanced stage of the disease as was suggested by the finding of lump in 60% and ascites in 20% of the cases. Radical resection, possible in only six cases, appears to be the best treatment. The effectiveness of radiotherapy and chemotherapy were disappointing. Prognostically, cases of localized and polypoidal lesions of the small bowel and Hodgkin lymphoma showed better survival.
Studies on the alkaline phosphatase rise following colon ischemia
Authors: Williams Russell A. , Wilson Samuel E. 
Published: February 2007

AbstractThe elevation of serum alkaline phosphatase (ALP) that develops in the dog after 24 hours of colon ischemia was studied to determine its tissue origin.Portal, hepatic, and aortic blood were sampled but no difference in ALP level among these sites was found.In sera shown to have a significant rise in ALP, other tests of liver function were unchanged from normal, suggesting the ALP did not originate from the liver.On electrophoresis the “ischemic ALP” migrated faster than a known liver ALP standard but more slowly than an intestinal ALP sample.
Immunoglobulins and immunoglobulin receptors associated with human malignant tumors
Authors: Krishnan Engikolai C. , Krishnan Leela , Jewell William R. 
Published: February 2007

AbstractOver the past five years 86 malignant tumors were assayed for cell surface IgG, elutable Ag‐Ab complexes, and/or cell surface Fc receptors. Surface IgG was measured by indirect radioimmunoassay, using single‐cell suspensions and tumor eluates. Fc receptors in tissue sections were identified by the closed chamber technique. The results confirm our previous finding that human tumors are coated in vivo with IgG and that there is a population of cells within solid tumors capable of binding Ag‐Ab complexes. In addition, Ag‐Ab complexes appear to attach to the cell surface membrane by the Fc zone of antibody. Ag‐Ab binding was inhibited by antibody raised against the tumor. Indirect complement consumption assay indicated the presence of Ag‐Ab complexes in tumor eluates. It appears that most cell surface immunoglobulin is complexed.