bluuebunny/crossref_metadata_2025_split huggingface dataset:
Olaparib in treatment‐refractory isocitrate dehydrogenase 1 (IDH1)– and IDH2‐mutant cholangiocarcinoma: Safety and antitumor activity from the phase 2 National Cancer Institute 10129 trial
Authors: Cecchini Michael , Pilat Mary Jo , Uboha Nataliya , Azad Nilofer S. , Cho May , Davis Elizabeth J. , Ahnert Jordi Rodon , Tinoco Gabriel , Shapiro Geoffrey I. , Khagi Simon , Powers Benjamin , Spencer Kristen , Groisberg Roman , Drappatz Jan , Chen Li , Das Biswajit , Bao Xun , Li Jing , Narayan Azeet , Vu Dennis , Patel Abhijit , Niger Monica , Doroshow Deborah , Durecki Diane , Boerner Scott A. , Bindra Ranjit , Ivy Percy , Shyr Derek , Shyr Yu , LoRusso Patricia M. 
Published: February 2025

AbstractBackgroundNeomorphic isocitrate dehydrogenase (IDH) mutations lead to the accumulation of 2‐hydroxyglutarate (2‐HG), an oncometabolite implicated in tumor progression via inhibitory effects on alpha‐ketoglutarate. Moreover, mutant IDH–dependent accumulation of 2‐HG results in homologous recombination deficiency (HRD), which preclinically renders tumors sensitive to poly(adenosine diphosphate ribose) polymerase inhibitors. Here, the results of the cholangiocarcinoma (CCA) arm of the National Cancer Institute (NCI) 10129 olaparib in IDH‐mutant solid tumors basket trial are reported.MethodsOlaparib 300 mg twice daily was evaluated in an open‐label, phase 2 clinical trial for treatment‐refractory IDH‐mutant solid tumors. Patients in the IDH‐mutant CCA arm enrolled in two cohorts: (1) IDH inhibitor (IDHi) pretreated and (2) IDHi untreated, with a primary end point of overall response rate.ResultsNCI 10129 enrolled 30 patients with IDH‐mutant CCA with no objective responses seen, and recruitment was closed early. Median progression‐free survival (PFS) was 2.4 months (95% CI, 1.9 to 6.5 months) and median overall survival was 12.9 months (95% CI, 6.3 months to not reached). Eight patients (27%) had clinical benefit (CB), with a PFS of ≥6 months. Patients with CB had lower baseline 2‐HG levels compared to those without CB (1.4 vs. 5.9 µmol/L; p = .01).ConclusionsOlaparib does not have sufficient single‐agent activity to warrant further development in IDH‐mutant CCA. However, a subgroup of patients demonstrated CB, and exploratory analysis revealed this subgroup to be enriched for lower baseline 2‐HG levels. Future clinical trials leveraging the HRD properties of IDH mutations are warranted with enhanced patient selection and novel combination therapies.
Progress and Perspectives of Lithium Isotope Separation
Authors: He Pengbing , Xie Qionghua , Wang Jinyu , Yao Guocheng , Wang Liangshi 
Published: February 2025

AbstractStabilized lithium isotopes (6Li, 7Li) play an important role in related fields such as energy and defense. With the advancement of nuclear technology, the demand for lithium isotopes is expected to increase significantly. Although the separation of lithium amalgam is effective, it poses greater pollution risks. Therefore, it is very important to establish an efficient, green and sustainable lithium isotope separation method. Lithium isotopes are extremely difficult to isolate, but the discovery of their differences in migration (diffusion) rates, optical excitation, magnetic field response, and chemical binding has enable their potential separation lithium isotopes. Among the various lithium isotope separation methods developed, electrochemical migration stands out as a technique with industrial potential due to its high single‐stage separation factor. Hence, this paper focuses on the research progress of lithium isotope separation methods with significant industrial potential. It elucidates the merits and challenges of various techniques, explores key obstacles to their industrialization. Finally, a method for separating lithium isotopes using solid electrolytes is described in the context of lithium‐ion battery technology and related research on lithium isotope separation. Despite being in its infancy, this method warrants further research and experimentation.
Environmental, Social, and Governance Ratings in the United Kingdom: Do Eco‐Innovation and Environmental Training Program Matter?
Authors: Emam Doaa , Borgi Hela , Alessa Noha , Albitar Khaldoon 
Published: February 2025

ABSTRACTThis study examines the impact of eco‐innovation and environmental training programs on corporate environmental, social, and governance (ESG) ratings in the United Kingdom (UK). The sample includes 1251 firm‐year observations from the London Stock Exchange between 2016 and 2021. Utilizing various regression models, our findings show that both eco‐innovation and environmental training programs significantly enhance corporate ESG ratings in the UK. Further analysis reveals that these programs are crucial drivers of ESG ratings, regardless of firm performance. These results have important implications for policymakers and governments, highlighting the need for action plans to support companies, both practically and financially, in adopting environmental innovations and green training initiatives for their employees.
Combining observational and experimental data to estimate environmental and species drivers of fungal metacommunity dynamics
Authors: Nenzén Hedvig Kristina , Moor Helen , O'Hara Robert B. , Jönsson Mari , Nordén Jenni , Ottosson Elisabet , Snäll Tord 
Published: February 2025

AbstractUnderstanding the distribution and dynamics of species is central to ecology and important for managing biodiversity. The distributions of species in metacommunities are determined by many factors, including environmental conditions and interactions between species. Yet, it is difficult to quantify the effect of species interactions on metacommunity dynamics from observational data. We present an approach to estimate the importance of species interactions that combines data from two observational presence–absence inventories (providing colonization–extinction data) with data from species interaction experiments (providing informative prior distributions in the Bayesian framework). We further illustrate the approach on wood‐decay fungi that interact within a downed log through competition for resources and space, and facilitate the succession of other species by decomposing the wood. Specifically, we estimated the relative importance of species interactions by examining how the presence of a species influenced the colonization and extinction probability of other species. Temporal data on fruit body occurrence of 12 species inventoried twice were jointly analyzed with experimental data from two laboratory experiments that aimed to estimate competitive interactions. Both environmental variables and species interactions affected colonization and extinction dynamics. Late‐successional fungi had more colonization interactions with predecessor species than early‐successional species. We identified several species interactions, and the presence of certain species changed the probability that later‐successional species colonized by −81% to 512%. The presence of certain species increased the probability that other species went extinct from a log by 14%–61%. Including the informative priors from experimental data added two colonization interactions and one extinction interaction for which the observational field data was inconclusive. However, most species had no detectable interactions, either because they did not interact or because of low species occupancy, meaning data limitation. We show how temporal presence‐absence data can be combined with experimental data to identify which species influence the colonization‐extinction dynamics of others. Accounting for species interactions in metacommunity models, in addition to environmental drivers, is important because interactions can have cascading effects on other species.
Study on Multiobjective Path Optimization of Plant Protection Robots Based on Improved ACO‐DWA Algorithm
Authors: Niu Jing , Shen Chuanyan , Zhang Lipeng , Gao Guanghao , Zheng Jiahao 
Published: February 2025

ABSTRACTThe use of large‐scale agricultural machinery for plant protection in nonstandard orchards of mountainous areas is very limited, while small‐wheeled robots have great application prospect. To address the false judgment of visual information caused by the shading of branches and leaves and the difficulty in avoiding obstacles in complex orchard terrain, an operation trajectory optimization approach based on the improved dynamic window algorithm (DWA) with ant colony optimization (ACO) was developed. First, the orchard environment information was acquired by laser radar, and the voxel method was used to reduce the point cloud density of orchard ground. The grid method was used to segment the point clouds. Using the K‐means clustering algorithm to extract navigation lines of the tree row. Second, combining with the kinematic model and the motion path constraints of robots, a series of candidate trace points were generated using the model‐based prediction algorithm (SBMPO). Then, using the improved ACO‐DWA algorithm, the robot access cost was integrated into the objective function of the search node, and the path planning was carried out online based on the environment grid map. Finally, in simulation and orchard validation scenes, the effects of this improved approach were checked through the simulation platform Matlab R2021 and ROS2 operating system. Simulation results on Matlab R2021 show that this improved algorithm has an average of 28%, 16% and 37% reduction in three indicators of the travel path, the number of detours, and the calculation time, respectively. In the orchard real‐time experiment, compared with other excellent algorithms, the navigation distance error is reduced obviously. These experimental results show that this method would obviously improve the robot access effect in the inner area between the tree row, significantly meet the requirements of high safety and speed level of robots in these scenes. Also, it could be applied in the field such as picking and spraying robots.
Experimental investigation and simulation of a helical coil heat exchanger with hematite thermal reservoir
Authors: Pandey Vijay Kumar , Prakash Om 
Published: February 2025

AbstractThis paper introduces an innovative helical coil heat exchanger using Hematite as a heat storage material, enhancing retention and thermal management. Parabolic trough collectors deliver heat to the heat exchanger's shell side using Therminol VP‐1 with Al2O3 nanoparticles, while another collector supplies vapor to the helical coil connected to a turbine. A concentric cylinder serves as a rechargeable heat reservoir. The study presents a control‐oriented modeling methodology for a practical TES tank with a helical immersed heat exchanger. Temperature dynamics of the heat transfer fluid within the tank are discretely modeled for computational efficiency in real‐time simulations. A simulated case with model‐based feedback control demonstrates the efficacy of this approach, validated by comparing simulation results with experimental data. Results show a close correlation between the surface temperature of the heat storage tank and the helical coil temperature, affirming model accuracy and reliability. The system achieves an efficiency of 37%. A case study involving a 1 Kw steam‐operated power plant (150–200°C, 7–10 bar, 50 kg/h) illustrates the practical application and benefits of the methodology in achieving intelligent and efficient TES system operation.
Evaluation and Performance of Menthol–Polyethylene Glycol LTTM in Carbon Dioxide Capture
Authors: Al‐Fazari Fatma R. , Mjalli Farouq S. , Shakourian‐Fard Mehdi , Kamath Ganesh , Naser Jamil , Murshid Ghulam , Ma'awali Suhaib Al 
Published: February 2025

ABSTRACTCarbon dioxide capture technology, while established, faces operational and economic challenges with current absorbents. Ionic liquids (ILs), though promising for their selectivity and low volatility, often have drawbacks like high toxicity and viscosity. This study explores nonionic low transition temperature mixtures (LTTMs) of menthol (MET) and polyethylene glycol 200 (PEG200) at various ratios for CO2 uptake. The 1:2 molar ratio showed maximum CO2 loading of 0.599 mol CO2/mol solvent at 303.15 K and 1000 kPa, with water addition boosting CO2 uptake by 25%. This rise in uptake with water could be due to altered hydrogen bonding within the mixture constituents. Molecular dynamics simulations support these findings, indicating experimental results, showing that water disrupts hydrogen bonds, exposing hydroxyl and ether sites for CO2 interaction. This LTTM solvent system presents a promising, low‐toxicity alternative for efficient CO2 capture. © 2025 Society of Chemical Industry and John Wiley & Sons, Ltd.
Petrogenesis and Geochronology of the Dagang Muscovite‐Granite in the Central Qinzhou‐Hangzhou Metallogenic Belt, South China: Implications for Lithium‐Enrichment Mechanism of Granite‐Type Lithium Ore Deposit
Authors: Jiang Xingfu , Ding Ting , Pan Bing , Li Tengxin , Han Yifei , Chen Yuzhuo , Zeng Xiangjin 
Published: February 2025

ABSTRACTThe central Qinzhou‐Hangzhou metallogenic belt in south China hosts large to supra‐large hard‐rock type lithium ore deposits. This contribution presents an integrated study of zircon U–Pb geochronology, whole‐rock and in situ Lu‐Hf isotopic geochemistry for the Dagang muscovite‐granite type Lithium ore deposit. LA‐ICP‐MS zircon U–Pb dating of five muscovite‐granitic samples yielded weighted average 206Pb/238U ages of 145 ± 3, 143 ± 1, 143 ± 1, 144 ± 3 and 144 ± 6 Ma, respectively, which are interpreted as the intrusion and mineralization ages of the granite. The Dagang granites have high SiO2, Na2O + K2O and Al2O3 contents that are similar to those of strongly peraluminous granites. All the samples are depleted in Ba, Nb and Ti elements, but enriched Rb, Ta, Pb and U elements, as well as they have large negative εHf(t) values of −11 ± 1.3, −8.1 ± 0.6, −6.7 ± 1.5, −8.6 ± 0.9 and −10.3 ± 2.3, which are indicative of dominantly Mesoproterozoic continental crustal metasedimentary in origin. There is no obvious correlation between SiO2 and Li, whereas SiO2/Al2O3 show negative correlation with Li, in combination with positive correlations of LOI, Rb, Cs and Li, as well as consensual genetic views of high‐U zircons, it is proposed that lithium enrichment of the muscovite‐granite type lithium ore deposit occurred late stage of crystallisation differentiation of silicic magmatic system during Al‐rich mineral precipitation, and are superimposed of hydrothermal alteration.
The Age and Provenance of Zaduo Group in the Qiangtang Basin: Constraints From Zircon U–Pb Geochronology and Palynology
Authors: Li Yanbin , Zheng Bo , Dai Jie , Zhang Yanxiong 
Published: February 2025

ABSTRACTA suite of organic‐carbon‐rich mudstones has been recently identified in the lower Carboniferous Zaduo Group in the eastern North Qiangtang Basin. Fossils from this group suggest an early Carboniferous depositional age. However, an unconformity recognised between the lower clastic rock unit and the upper carbonate unit of the Zaduo Group indicates a sedimentary hiatus. Here, we report detrital zircon U–Pb geochronological and sporopollen fossil data from the lower clastic rock unit of the Zaduo Group to examine its age. All the eight samples contain Triassic zircons and give a maximum depositional age of Late Triassic, which could also be indicated by the sporopollen results. This age revision has been roughly checked over a spatial span of 300 km in the eastern North Qiangtang Basin. The detrital zircon U–Pb age patterns highly resemble those from the Triassic Bagong Formation in the Qiangtang Basin and Upper Triassic flysch deposits in the Songpan‐Garze Terrane. Considering the similarities in organic‐carbon content, detrital zircon age patterns, rock assemblages, and spatial distributions between the lower clastic rock unit of the Zaduo Group and the Bagong Formation, it is quite possible that the lower unit of the Zaduo Group is an extension of the Bagong Formation. Moreover, the mudstones of Bagong Formation are the most important source rocks in the Qiangtang Basin, which requires more details and caution to verify the depositional age of the Zaduo Group. Further, the age revision highlights the need for caution to reevaluate the distribution of source rocks in the Qiangtang Basin.
Transoral Surgery Versus Radiotherapy as Primary Treatment for HPV‐Related Oropharyngeal Cancer in the Elderly
Authors: Costantino Andrea , Haughey Bruce , Zhu Jianbin , Alamoudi Uthman , Magnuson J. Scott 
Published: February 2025

ABSTRACTBackgroundThis study compares the oncological outcomes of primary transoral surgery (TOS) and primary radiotherapy (RT) in elderly patients with HPV‐related oropharyngeal squamous cell carcinoma (OPSCC).MethodsThis retrospective cohort study included patients with cT1‐2 HPV‐related OPSCC from the National Cancer Database (NCDB).ResultsA total of 2566 patients were included, with 73.9% receiving primary RT and 22.3% undergoing primary TOS. Subgroup analysis showed a higher 5‐year overall survival (OS) rate for primary TOS (81.6%; 95% CI: 79.6%–83.6%) compared to primary RT (70.7%; 95% CI: 68.3%–73.1%), with an adjusted hazard ratio (HR) of 0.64 (95% CI: 0.50–0.81; p < 0.001) after propensity score matching. Notably, only (13.6%) of patients diagnosed in 2020 underwent primary TOS, with a significant decline over the study period.ConclusionsThis study suggests that primary TOS may offer better survival outcomes for elderly patients with HPV‐related OPSCC compared to primary RT.
CD8+ T cells in patients with hypopharyngeal squamous cell carcinoma are susceptible to radiation‐induced damage
Authors: Lin Hanqing , Ma Jingyu , Heng Yu , Zhu Xiaoke , Jin Qiuyan , Ding Xuping , Tao Lei , Lu Liming 
Published: February 2025

AbstractRadiotherapy (RT) is a commonly used clinical management for hypopharyngeal squamous cell carcinoma (HPSCC), which represents the most unfavorable prognosis among all subtypes of head and neck squamous cell carcinoma. However, radiation may cause lymphopenia, a significantly adverse event with detrimental prognostic implications for patients. While CD8+ T cells are vital in tumor immunity, the specific effects of RT on CD8+ T cells as well as the underlying mechanisms have not been clearly elucidated. Here we found that subpopulations of peripheral T lymphocytes exhibited differential profiles in patients with HPSCC compared to healthy individuals both pre‐ and post‐irradiation. Importantly, CD8+ T cells from HPSCC patients showed greater reduction of cytokine production, more severe proliferation defect, and increased apoptosis compared to those from healthy individuals after in vitro irradiation. Mechanistically, the ATM‐Chk2 pathway mediated the enhanced apoptosis of CD8+ T lymphocytes from HPSCC patients upon irradiation. Therefore, our study demonstrated that CD8+ T cells in patients with HPSCC exhibit a higher susceptibility to radiation‐induced damage compared to those in healthy individuals. The ATM‐Chk2 pathway represents a potential immunotherapeutic target for safeguarding CD8+ T cells in HPSCC patients against radiation‐induced apoptosis.
The prevalence, types, and risk factors of urinary incontinence among Bangladeshi women aged 15–49: A study based on a nationally representative survey
Authors: Nahar Quamrun , Alam Anadil , Sheikh Sifat Parveen , Shiblee Shafayatul Islam , Khan Shusmita , Rahman Mizanur 
Published: February 2025

AbstractObjectiveTo estimate the prevalence of urinary incontinence (UI), its subtypes, and the associated risk factors in women of reproductive age in Bangladesh.MethodsData from the 2016 Bangladesh Maternal Mortality and Health Care Survey was analyzed in a nationally representative sample of 298 284 households that used a multistage sample selection procedure. Data on 183 560 ever‐married women aged 15–49 years who had ever given birth were analyzed. Descriptive statistics was used to report the overall prevalence of any UI and its three subtypes: stress, urge, and mixed UI. The wealth index of each household was constructed using principal component analysis. Univariable and multivariable binary logistic regression analyses were conducted to identify the factors associated with each type of UI.ResultsThe prevalence of any UI was 15.9% (95% confidence interval [CI]:15.7–16.1). Stress incontinence was the most prevalent UI (8.3%, 95% CI: 8.2–8.4), followed by mixed type (5.5%, 95% CI: 5.4–5.6), and urge incontinence (2.1%, 95% CI: 2.1–2.2). In multivariate logistic regression analysis, older age, no or less education, younger age at first birth, higher parity, lower wealth status, self‐reported pelvic organ prolapse (POP), and being Muslim had a significant positive association with the presence of UI.ConclusionsAbout one in six women reported to have suffered from any type of UI in this study. Several common risk factors were found, which call for targeted policy and programmatic interventions.
Toll‐Like Receptors in Pentachlorophenol‐ and Dibutyltin‐Induced Production of Pro‐Inflammatory Cytokines, Interleukin (IL)‐1β, and IL‐6, by Human Immune Cells
Authors: Seaton‐Terry Aleshia , Hunter Zinia , Lewis Meaghan , Fisher Sophia , Bray Ellie , Townsend Brian , Gabure Saleban , Daniel Latoya , Whalen Margaret 
Published: February 2025

ABSTRACTPentachlorophenol (PCP) and dibutyltin dichloride (DBT) contaminate the environment due to their diverse applications. PCP has been found from 0.26 to 5 μM in the serum of exposed individuals and at an average of 0.15 μM in the unexposed. DBT has been detected in human blood at levels up to 0.3 μM. Exposure to these contaminants is linked to pathological conditions including cancer. Interleukin‐1 beta (IL‐1β) and IL‐6 are pro‐inflammatory cytokines that when produced inappropriately can cause chronic inflammation, which is linked to pathologies including autoimmune diseases and cancer. PCP and DBT have been shown to increase the production of IL‐1β and IL‐6 by immune cells in a MAP kinase (MAPK) dependent process. Toll‐like receptors (TLRs) activate the signaling pathways linked to MAPK that lead to production of these cytokines. This study demonstrates that PCP‐induced production of IL‐1β and IL‐6 is dependent on TLR4 and TLR8, and independent of TLR1/2, TLR2, and TLR3. Additionally, DBT‐induced IL‐6 production depends on TLR1/2, whereas IL‐1β production does not. Blocking the TLR‐linked adapter protein, MyD88, lead to a loss of both PCP and DBT stimulation of IL‐1β and IL‐6. These findings indicate that both PCP and DBT interact with selected TLRs as part of their mechanisms of elevating the levels of critical pro‐inflammatory cytokines, which may contribute to chronic inflammation and its related pathologies.