bluuebunny/crossref_metadata_2025_split huggingface dataset:
A computational model of Alzheimer's disease at the nano, micro, and macroscales
Authors: Chamberland Éléonore , Moravveji Seyedadel , Doyon Nicolas , Duchesne Simon 
Published: March 2024

IntroductionMathematical models play a crucial role in investigating complex biological systems, enabling a comprehensive understanding of interactions among various components and facilitating in silico testing of intervention strategies. Alzheimer's disease (AD) is characterized by multifactorial causes and intricate interactions among biological entities, necessitating a personalized approach due to the lack of effective treatments. Therefore, mathematical models offer promise as indispensable tools in combating AD. However, existing models in this emerging field often suffer from limitations such as inadequate validation or a narrow focus on single proteins or pathways.MethodsIn this paper, we present a multiscale mathematical model that describes the progression of AD through a system of 19 ordinary differential equations. The equations describe the evolution of proteins (nanoscale), cell populations (microscale), and organ-level structures (macroscale) over a 50-year lifespan, as they relate to amyloid and tau accumulation, inflammation, and neuronal death.ResultsDistinguishing our model is a robust foundation in biological principles, ensuring improved justification for the included equations, and rigorous parameter justification derived from published experimental literature.ConclusionThis model represents an essential initial step toward constructing a predictive framework, which holds significant potential for identifying effective therapeutic targets in the fight against AD.
Case report: Solitary mass of the sciatic nerve confirmed as a primary extranodal manifestation of diffuse large B-cell lymphoma in a geriatric patient
Authors: Becker Hannes , Vogelsberg Antonio , Feucht Daniel , Estler Arne , Tafrali Deniz , Schittenhelm Jens , Milla Jakob , Kurz Sylvia , Fend Falko , Tatagiba Marcos , Schuhmann Martin U. , Hurth Helene 
Published: March 2024

BackgroundNeoplastic lesions affecting peripheral nerves are rare in the general population and, most often, are benign peripheral nerve sheath tumors. However, a minority of lesions represent high-grade malignancies associated with a poor prognosis, such as malignant peripheral nerve sheath tumors (MPNSTs). Very rarely, these tumors represent peripheral non-nerve sheath tumors (PNNSTs), such as hematological neoplasms that impair nerve function. These can be hard to distinguish from MPNSTs and other lesions arising from the nerve itself. In the present case report, we describe a rare case of direct infiltration of nerves by tumor cells of a hematological neoplasm.MethodsWe report the case of a 90-year-old woman with acute onset of right-sided foot palsy, sensory loss, and pain, caused by an extensive solitary mass of the sciatic nerve in the thigh. We present and discuss the clinical presentation, multimodal diagnostic procedures, and treatment.ResultsMRI of the right thigh and the caudal pelvis revealed a contrast-enhancing lesion infiltrating the sciatic nerve. Additionally performed staging imaging was non-revealing. After multidisciplinary discussion in the neuro-oncology tumor board, a MPNST was suspected and the patient underwent radical tumor resection. However, final histopathology revealed a diffuse large B-cell lymphoma (DLBCL). The patient received adjuvant palliative local radiotherapy which led to acceptable symptom control.ConclusionRare PNNSTs, including extranodal manifestations of DLBCL can have similar clinical and radiological diagnostical features as PNSTs. Comprehensive diagnostic workup of contrast-enhancing lesions affecting peripheral nerves including MRI and metabolic imaging are recommended. Discussion in interdisciplinary tumor boards facilitates finding individual treatment approaches.
One Health Education Nexus: enhancing synergy among science-, school-, and teacher education beyond academic silos
Authors: Hobusch Ulrich , Scheuch Martin , Heuckmann Benedikt , Hodžić Adnan , Hobusch Gerhard M. , Rammel Christian , Pfeffer Anna , Lengauer Victoria , Froehlich Dominik E. 
Published: March 2024

IntroductionThe fact that the daily lives of billions of people were affected by the medical, social, and political aspects of the SARS-CoV-2 pandemic shows the need to anchor the understanding of One Health in society. Hence, promoting awareness and deepening the understanding of the interrelation between human health, animal health, and ecosystems must be accomplished through quality education, as advocated by UN Sustainable Development Goal 4. The often-questioned and discussed measures taken by governments to control the global pandemic between 2020 and 2023 can be seen as an opportunity to meet the educational needs of civil society solutions in multi-stakeholder settings between public, universities, and schools.MethodsThis paper focuses on the integration of One Health principles in educational frameworks, particularly within the context of the higher education teaching framework “Teaching Clinic.” This master-level course in the domain of pre-service teacher education serves as a potent vehicle for facilitating One Health Education, bridging the gap between research, higher education, and schools. Through the presentation of two case studies, this article demonstrates how the Teaching Clinic approach fosters interdisciplinary perspectives and provides a dynamic learning environment for pre-service teachers, as well as for pupils involved in the educational process.ResultsIn both cases, the integration of educational One Health school teaching-learning settings effectively enhanced pupils’ understanding of complex topics and engaged them in active learning experiences. Pre-service teachers played a crucial role in developing, implementing, and evaluating these interventions. In Case I, pupils demonstrated proficiency in analyzing data and evaluating mathematical models, while in Case II, the chosen instructional approach facilitated One Health knowledge acquisition and enjoyment among pupils. These results underscore the potential of the One Health Teaching Clinic as a valuable educational framework for enhancing teaching and learning outcomes for pre-service teachers and fostering pupil engagement in socio-scientific One Health-related topics.DiscussionThe discussion delves into the significance of breaking down disciplinary silos and the crucial role of teacher education in promoting a holistic approach to education, emphasizing the intersectionality of One Health Education and Education for Sustainable Development. This article underpins the significance of collaborative efforts across multiple (scientific) disciplines and across secondary and tertiary education levels to reach a nexus. Moreover, it emphasizes the alignment of this approach with the 2030 Agenda, Education for Sustainable Development, and Sustainable Development Goals, highlighting the potential for collective action toward a more sustainable future.
Construction and verification of risk prediction model of osteoporotic fractures in patients with osteoporosis in China
Authors: Xia Peifang , Jiang Yingqing , Cai Feng , Peng Shuzhi , Xu Zhouya 
Published: March 2024

ObjectiveTo explore the influencing factors of osteoporotic fractures (OPF) in patients with osteoporosis, construct a prediction model, and verify the model internally and externally, so as to provide reference for early screening and intervention of OPF in patients with osteoporosis.MethodsOsteoporosis patients in the First Affiliated Hospital of Soochow University were selected, and the medical records of patients were consulted through the Hospital Information System (HIS) and the data management platform of osteoporosis patients, so as to screen patients who met the criteria for admission and discharge and collect data. SPSS 26.0 software was used for single factor analysis to screen statistically significant variables (p &lt; 0.05). The influencing factors of OPF were determined by multivariate analysis, and a binary Logistic regression model was established according to the results of multivariate analysis. Hosmer-Lemeshow (H-L) goodness of fit and receiver operating characteristic curve (ROC) were used to test the model’s efficiency, and Stata 16.0 software was used to verify the Bootstrap model, draw the model calibration curve, clinical applicability curve and nomogram.ResultsIn this study, the data of modeling set and verification set were 1,435 and 580, respectively. There were 493 (34.4%) cases with OPF and 942 (65.6%) cases without OPF in the modeling set. There were 204 (35.2%) cases with OPF and 376 (64.8%) cases without OPF. The variables with statistically significant differences in univariate analysis are Age, BMI, History of falls, Usage of glucocorticoid, ALP, Serum Calcium, BMD of lumbar, BMD of feminist neck, T value of feminist neck, BMD of total hip and T value of total hip. The area under ROC curve of the risk prediction model constructed this time is 0.817 [95%CI (0.794 ~ 0.839)], which shows that the model has a good discrimination in predicting the occurrence of OPF. The optimal threshold of the model is 0.373, the specificity is 0.741, the sensitivity is 0.746, and the AUC values of the modeling set and the verification set are 0.8165 and 0.8646, respectively. The results of Hosmer and Lemeshow test are modeling set: (χ2 = 6.551, p = 0.586); validation set: [(χ2 = 8.075, p = 0.426)]. The calibration curve of the model shows that the reference line of the fitted curve and the calibration curve is highly coincident, and the model has a good calibration degree for predicting the occurrence of fractures. The net benefit value of the risk model of osteoporosis patients complicated with OPF is high, which shows that the model is effective.ConclusionIn this study, a OPF risk prediction model is established and its prediction efficiency is verified, which can help identify the high fracture risk subgroup of osteoporosis patients in order to choose stronger intervention measures and management.
A novel method to derive a human safety limit for PFOA by gene expression profiling and modelling
Authors: Silva Arthur de Carvalho e , Loizou George D. , McNally Kevin , Osborne Olivia , Potter Claire , Gott David , Colbourne John K. , Viant Mark R. 
Published: March 2024

Perfluorooctanoic acid (PFOA) is a persistent environmental contaminant that can accumulate in the human body due to its long half-life. This substance has been associated with liver, pancreatic, testicular and breast cancers, liver steatosis and endocrine disruption. PFOA is a member of a large group of substances also known as “forever chemicals” and the vast majority of substances of this group lack toxicological data that would enable their effective risk assessment in terms of human health hazards. This study aimed to derive a health-based guidance value for PFOA intake (ng/kg BW/day) from in vitro transcriptomics data. To this end, we developed an in silico workflow comprising five components: (i) sourcing in vitro hepatic transcriptomics concentration-response data; (ii) deriving molecular points of departure using BMDExpress3 and performing pathway analysis using gene set enrichment analysis (GSEA) to identify the most sensitive molecular pathways to PFOA exposure; (iii) estimating freely-dissolved PFOA concentrations in vitro using a mass balance model; (iv) estimating in vivo doses by reverse dosimetry using a PBK model for PFOA as part of a quantitative in vitro to in vivo extrapolation (QIVIVE) algorithm; and (v) calculating a tolerable daily intake (TDI) for PFOA. Fourteen percent of interrogated genes exhibited in vitro concentration-response relationships. GSEA pathway enrichment analysis revealed that “fatty acid metabolism” was the most sensitive pathway to PFOA exposure. In vitro free PFOA concentrations were calculated to be 2.9% of the nominal applied concentrations, and these free concentrations were input into the QIVIVE workflow. Exposure doses for a virtual population of 3,000 individuals were estimated, from which a TDI of 0.15 ng/kg BW/day for PFOA was calculated using the benchmark dose modelling software, PROAST. This TDI is comparable to previously published values of 1.16, 0.69, and 0.86 ng/kg BW/day by the European Food Safety Authority. In conclusion, this study demonstrates the combined utility of an “omics”-derived molecular point of departure and in silico QIVIVE workflow for setting health-based guidance values in anticipation of the acceptance of in vitro concentration-response molecular measurements in chemical risk assessment.
A blinded, randomized and controlled multicenter field study investigating the safety and efficacy of long-term use of enflicoxib in the treatment of naturally occurring osteoarthritis in client-owned dogs
Authors: Homedes Josep , Ocak Marion , Riedle Sebastian , Salichs Marta 
Published: March 2024

BackgroundEnflicoxib is a COX-2 selective NSAID shown to be efficacious and safe in the treatment of pain and inflammation associated with canine osteoarthritis (OA) in clinical studies of 6 weeks duration.ObjectiveThis prospective, multisite, blinded, randomized, placebo-controlled, parallel-group field study aimed to confirm the safety and efficacy of enflicoxib in long-term canine OA treatments.AnimalsA total of 109 client owned dogs with clinical and radiographic signs of OA for at least 3 weeks were enrolled with 78 dogs completing all study visits.MethodsDogs were randomized at a 3:1 ratio to receive enflicoxib (n = 83) or placebo (n = 26) once weekly during 6 months. Dogs underwent veterinary assessments from Day 0 to Day 189 using a clinical sum score (CSS). Efficacy was also assessed by the owners using the Canine Brief Pain Inventory (CBPI). Safety was assessed clinically and by repeated blood and urine sample analysis. The efficacy outcome measure was the treatment response according to the CSS and secondarily the treatment response according to the CBPI. The primary safety outcome was the incidence of adverse events (AEs) and secondarily the evolution of the clinical pathology parameters.ResultsPercentages of CSS responders for enflicoxib were 71.6; 74.6 and 71.6% on Days 44, 135 and 189 respectively, always showing statistically significant differences (p &lt; 0.05) vs. placebo (41.7, 33.3, and 20.8% respectively). Treatment response according to owner assessments followed the same pattern, achieving significant differences compared to placebo after 2 weeks of treatment. The incidence and type of AEs were as described in previous enflicoxib studies of shorter duration and as for other NSAIDs, with no tendency to increase over time. No relevant changes in hematology, biochemistry or urine parameters were observed.Conclusions and clinical relevanceEnflicoxib safety and efficacy profile is maintained after a long-term treatment, which together with its weekly administration, makes it a good alternative for the chronic treatment of dogs with naturally occurring OA.
New Euthemistid Damsel–Dragonfly from the Middle Jurassic of Northern China (Odonata, Isophlebioidea, Euthemistidae)
Authors: Liu Yuxuan , Shi Chaofan , Shang Jingan , Ren Dong , Yang Qiang 
Published: March 2024

A new genus and new species of the euthemistid, Kidaneuthemis ningchengensis gen. et sp. nov., is described from the Middle Jurassic of Inner Mongolia, China. It can be assigned to the Euthemistidae by the several long intercalary veins between RP1 and IR1, IR1 and RP2, as well as between RP2 and IR2 and between IR2 and RP3/4. Kidaneuthemis ningchengensis gen. et sp. nov. distinguishes from the other two genera of this family by the presence of not less than eight intercalary veins between MP and wing margin; about three rows of cells in the distal part between MA and MP; the base of IR2 is two cells distal to that of RP3/4. In addition, a revision of the family Euthemistidae has been proposed.
DEVELOPMENT OF KEY COMPETENCIES OF FUTURE SPECIALISTS IN ART AND EXTRACURRICULAR EDUCATION
Authors: Lebedyk L. 
Published: March 2024

The article is devoted to the actual problem of the development of key competencies of future specialists in art and extracurricular education. The author outlines a range of problematic issues that arise in the process of training students of the master’s level of the educational and professional programs “Extracurricular Education” (specialty 011 Educational, pedagogical sciences of the field of knowledge 01 Education/Pedagogy) and “Choreography” (specialty 024 Choreography of the field of knowledge 02 Culture and Art) and offers areas of activity for the development of their key competencies.
The study has revealed the importance of applying knowledge in practice by future specialists of art and extracurricular education, which helps them gain experience, readiness for future professional activities, and life skills. Experts consider readiness for future professional activity to be: strategic thinking, decision-making, the ability to plan, goal setting and achievement, responsibility, interaction and cooperation, teamwork, ability to apply professional knowledge and learning technologies, the ability to think critically, recollection, self-sufficiency, efficiency, punctuality. Life skills are social skills, communication skills, the ability to reach consensus, the ability to take responsibility, self-respect, non-conflict, endurance, and strengthening values and ethics.
It has been proven that the development of key competencies of future specialists in art and extracurricular education should be based on systemic, problem-based, personal, competence, and contextual approaches, and forms of interaction – master classes, scientific conferences, trainings, educational and entertainment events, competitions of professional skills, modeling of professional situations.
It has been concluded that it is necessary to further search for and improve ways of developing the key competencies of future specialists in art and extracurricular education to develop strategic perspective educational and professional programs for their training.
THE KEY COMPETENCES OF ECONOMICS COLLEGE TEACHER AS THE BASIS FOR THEIR RESILIENCE DEVELOPMENT
Authors: Strelnikov V. 
Published: March 2024

The possibilities of the author’s professional development courses “Technologies of Effective Pedagogical Communication, Psychodiagnostics and Provision of Psychological Support to Participants of the Educational Process in Institutions of Professional Pre-Higher Education” for the development of the resilience of economic college teachers in war conditions based on their key competencies, in particular personal, social and educational competence, are considered. The experience of the Poltava Academy of Continuing Education named after M. V. Ostrogradskyi to fulfill the requirement of the Ministry of Education and Culture of Ukraine to ensure that teachers pass advanced training courses to improve their knowledge, skills, and practical skills to provide psychological support to participants in the educational process in wartime conditions is shown.
The article outlines the essence of the following terms: “key competencies” (necessary for the growth of a person’s personal potential and development, expansion of his opportunities for employment, social integration, active citizenship), “personal, social and educational competence” (the ability to be aware of one’s own internal states, effectively manage time and information, work constructively with other people, remain stable and manage one's own education and career), “resilience” (a dynamic, complex, multidimensional set of characteristics personality, its ability to resist and adapt to adverse and traumatic events), “resilience” (the ability of an individual to withstand the difficulties of life, quickly recover, successfully adapt in adverse circumstances, a dynamic personality property that can and should be developed, although it is innate).
Resilience is considered as a) a concept; b) a process; c) a result; and also as a) personality quality (ability to overcome stress); b) a coping process (psychological strategy and method of overcoming a stressful situation); c) adaptive protective mechanism of the individual (allows to adapt after mental trauma or resist stress). The components of the resilience of economic college teachers are determined – adaptability, stability, hope, optimism. The expediency of following the self-help rules and advice for the development of the teacher’s resilience in the conditions of war, which are used in professional development courses, is substantiated.
The methodological principles of conducting professional development courses for the development of economic college teachers’ resilience in the conditions of war based on their key competencies (in particular, personal, social, and educational competence) are singled out. They are the following: a) continuity; b) science; c) visibility; d) objectivity; e) developmental training; f) democratization; g) self-development of the individual; h) psychological support.
Beckett et Bion
Authors: Anzieu Didier 
Published: March 2024

Beckett and Bion.
Beckett underwent psychoanalysis for two years (1934-35) with Bion in London before emigrating to Paris where he began, in French, his most significant literary work as a writer of fiction. The author of this article explores Beckett’s works for the trace of his interrupted psychoanalytical experience, and more particularly for the transposition of the psychonalytical situation and the working through of negative transference.
Furthermore, it can be seen that Beckett’s heroes and narrators often anticipate ideas and formulae which can later be found in Bion. The author thus reaches the hypothesis that Bion was profoundly implicated in the psychoanalysis of Beckett, in whom found several of his characteristics (cynicism, aloofness, depression). Bion and Beckett probably represented for each other, mutually, the secret imaginary twin.
Lieux communs de l’élaboration plurielle du contre-transfert en situation de groupe
Authors: Vidal Jean-Pierre 
Published: March 2024

Common places of the plural elaboration of the counter-transference in groupal circonstances.
The question is, for the author; to drax metapsychological inferences inscribed in the upsetting reality of the counter-transference, both as an experience (this one which reveals the partial settlement of the other in oneself) and as a concept. This one implies a common psychical space of which condions of possibility lie in the refusal, from now on, of considerering the psyche as a close and individed entity. Bot, if this one’s limits are comparatively indecided and pervious it is owing to her actual nature. Consequence of her own division (that is to say of her essential groupa-lity) she must be understood as an inside out side (inner exteriority). It results prom this, an original ability to form associating connections an to build «dissubjectivated» psychical spaces perfect common places of which we pind the spatial analogy in these created (elected) spaces for meeting and working. These externalized spaces of a groupal psychical topography would be both the wittnesses and the revealer of it. We should not consider them as neutral and insignificant; in this respect, they are the soitable places for the counter-transferencial analysis as plural elaboration, when the opportunity occurs, for those of the «intertranferencial analysis».
Un groupe thérapeutique pour «deuils spéciaux». Le problème du savoir
Authors: Braun de Dunayevich Julia , Puget Janine 
Published: March 2024

A therapeutic group for «special mourning». The problem of knowledge
Group therapeutic space allows us to recognise the effect of social violence exercised by State terrorism. We are studying the repercussions on exchanges within groups and in the individual psyche of each of its members. We have focussed on the process of mourning, the permeability between social context and the group , the transformation of panic and the reflection of induction methods within the social context, as well as knowledge and the mental significance of disappearance.