bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managerial control or feedback provision: How perceptions of algorithmic HR systems shape employee motivation, behavior, and well‐being
Authors: Edwards Martin R. , Zubielevitch Elena , Okimoto Tyler , Parker Stacey , Anseel Frederik 
Published: April 2024

AbstractAlgorithmic HR systems are becoming a more prevalent interface between organizations and employees. Yet little research has examined how automated HR processes impact employee motivation. In a three‐wave study (NTime1 = 401; NTime2 = 379; NTime3 = 303), we investigated the motivational effects of HR systems that automatically capture—and make decisions based on—employee performance, and whether these effects depend on employee attributions regarding the organization's intended use of its automated HR metric system. Additionally, we test whether these motivational states affect employee task prioritization and emotional exhaustion. Results show that employees whose organizations use algorithmic HR systems, and who also attribute managerial control as intent to that system, experience higher levels of extrinsic motivation at work. This, in turn, predicts greater prioritization of metricized tasks and de‐prioritization of non‐metricized tasks. Conversely, employees who believe the purpose of algorithmic HR systems is to provide them with constructive feedback are more likely to experience intrinsic motivation, leading to reduced feelings of emotional exhaustion, greater prioritization of metricized tasks, but reduced non‐metricized behavior de‐prioritization. These results illustrate the critical importance of employee sensemaking around algorithmic HR systems as a precursor to the impact of such systems on employee motivation, behavior, and well‐being.
Study of the enhancement in the performance of a hybrid flat plate solar collector using water and air as working fluids
Authors: Kutafa Shams Kamil , Muhammed Al‐Saiydee Mahmmod A. 
Published: April 2024

AbstractA hybrid flat solar collector was manufactured from basic materials to combine the effects of both water and air solar heaters. The reason is to increase the amount of heat delivered to water by doubling the heat sources, one from the direct beam of sun and the other from the hot air delivered by the air solar heater. In addition, the flow of water inside the solar heater is made in a thin layer so that much heat can be gained by water per unit time. The outlet hot air of the solar air heater enters air ducts that pass through the solar water heater. With a constant water flowrate of 0.0167 kg/s, three different air velocities (1.7, 2.1, and 2.4 m/s) were applied to determine the optimum air velocity that results in the maximum outlet water temperature and the maximum removal factor FR for the solar water heater. The experiment was run from 10:00 a.m. to 2:00 p.m. every day during June 2023 and the data was recorded every 15 min. The data obtained from the experiment showed that the lowest air speed (1.7 m/s) results in the highest outlet water temperature (63°C) and heat removal factor FR (0.74).
Pharmacological treatment of ectopic pregnancy: Accuracy, safety and cost‐effectiveness of day 1–7 β‐hCG measurements
Authors: Dayan‐Schwartz Adi , Abd Elgani Suzan , Abdul‐Ghani Tamam , Kogan Liron , Reiss Ari , Tal Alon 
Published: April 2024

AbstractObjectiveThe aim of the present study was to compare accuracy, safety and cost‐effectiveness of three β‐hCG measurements protocols, applied in managing ectopic pregnancies (EP) with methotrexate (MTX): (1) day 1 to 7 β‐hCG levels, (2) day 1 to 4 β‐hCG levels and (3) day 4 to 7 β‐hCG levels.MethodsCost‐minimization analysis (CMA) based on a retrospective study of patients treated with single‐dose MTX for EP, was evaluated at a single institution between January 2001 to May 2021. Successful MTX treatment was defined as no surgical intervention. We evaluated safety by analyzing cases of day 4 interventions and cases of inconsistency between the different protocols. Predicting accuracy was assessed by the area under the receiver operating characteristic (AUC) curve.ResultsA total of 229 patients with single dose MTX treatment were included. Overall, 184 (80.3%) patients were treated successfully with a single dose of MTX. For days 1 and 7 the optimal cutoff point was 7% reduction in β‐hCG levels with sensitivity, specificity and PPV of 76.6% (69.9–82.5, 95% CI), 75.5% (60.5–87.1, 95% CI) and 92.8% (88.4–95.6, 95% CI), respectively. There was no significant difference between the protocols' AUC. None of the patients had any change of management during their day 4 visit in our 20 years of records. The cost for each visit day (day 4 and 7) was calculated with a total cost of 251 USD per patient.ConclusionPatients treated with MTX for EP, measurement of day 1 and day 7 β‐hCG serum levels has a cost minimization advantage and is not inferior to the traditional protocol for predictive accuracy and safety.
Retrospective consecutive controlled case series of outcomes for functional analyses of severe destructive behavior
Authors: Weber Jessie K. , Brown Katherine R. , Retzlaff Billie J. , Hurd Alyssa M. , Anderson Heather J. , Smallwood Kendra 
Published: April 2024

AbstractFunctional analysis methods allow clinicians to determine the variable(s) that maintain destructive behavior. Previous reviews of functional analysis outcomes have included large samples of published and unpublished data sets (i.e., clinical samples). The purpose of this review was to conduct a large retrospective consecutive controlled case series of clinical functional analyses. We sought to identify the prevalence of differentiation, procedural modifications for undifferentiated and differentiated cases, and identified function(s) of destructive behavior. In addition, we extended the existing literature by determining whether functional analysis differentiation and function varied when single or multiple behavior topographies were consequated in the functional analysis. We discuss our findings considering previously published functional analysis reviews, provide avenues for future research, and offer suggestions for clinical practice.
Corporate debt booms, financial constraints, and the investment nexus
Authors: Albuquerque Bruno 
Published: April 2024

SummaryHow do corporate debt booms affect investment? Using US firm‐level data over 1984Q1–2019Q4, and an instrument for firm‐specific debt booms that exploits systematic differences in firms' exposure to industry‐level debt booms, I find that debt booms cause investment growth to decline over the medium term. This result is driven by the financial constraints channel: Vulnerable firms experience a higher cost of debt in the short run, lower stock returns, and an increase in indicators proxying financial risk. Vulnerable firms also cut their investment spending after a debt boom, irrespective of their growth opportunities. Finally, I find that congestion effects from vulnerable firms on healthy firms are amplified during debt booms, stressing the risk that debt booms in a subset of firms may spill over to the rest of the economy.
In vitro evaluation of bone cell response to novel 3D‐printable nanocomposite biomaterials for bone reconstruction
Authors: Haghpanah Zahra , Mondal Dibakar , Momenbeitollahi Nikan , Mohsenkhani Sadaf , Zarshenas Kiyoumars , Jin Yutong , Watson Michael , Willett Thomas , Gorbet Maud 
Published: April 2024

AbstractCritically‐sized segmental bone defects represent significant challenges requiring grafts for reconstruction. 3D‐printed synthetic bone grafts are viable alternatives to structural allografts if engineered to provide appropriate mechanical performance and osteoblast/osteoclast cell responses. Novel 3D‐printable nanocomposites containing acrylated epoxidized soybean oil (AESO) or methacrylated AESO (mAESO), polyethylene glycol diacrylate, and nanohydroxyapatite (nHA) were produced using masked stereolithography. The effects of volume fraction of nHA and methacrylation of AESO on interactions of differentiated MC3T3‐E1 osteoblast (dMC3T3‐OB) and differentiated RAW264.7 osteoclast cells with 3D‐printed nanocomposites were evaluated in vitro and compared with a control biomaterial, hydroxyapatite (HA). Higher nHA content and methacrylation significantly improved the mechanical properties. All nanocomposites supported dMC3T3‐OB cells' adhesion and proliferation. Higher amounts of nHA enhanced cell adhesion and proliferation. mAESO in the nanocomposites resulted in greater adhesion, proliferation, and activity at day 7 compared with AESO nanocomposites. Excellent osteoclast‐like cells survival, defined actin rings, and large multinucleated cells were only observed on the high nHA fraction (30%) mAESO nanocomposite and the HA control. Thus, mAESO‐based nanocomposites containing higher amounts of nHA have better interactions with osteoblast‐like and osteoclast‐like cells, comparable with HA controls, making them a potential future alternative graft material for bone defect repair.
Clinical utility of C‐reactive protein‐to‐albumin ratio in the management of patients with inflammatory bowel disease
Authors: Nguyen Anke L , Brick Claudia , Liu David , Gibson David J , Gibson Peter R , Sparrow Miles P 
Published: April 2024

AbstractBackground and AimC‐reactive protein (CRP)‐to‐albumin ratio (CAR) is a novel score with prognostic value in inflammatory conditions. This study assessed the performance of CAR as an objective marker of disease activity and prediction of subtherapeutic infliximab trough levels in patients with inflammatory bowel disease (IBD).MethodsA retrospective study was conducted on three different patient cohorts with IBD: patients who had (i) fecal calprotectin (FC) measurements; (ii) Mayo Endoscopic Scores; and (iii) infliximab trough levels available. The relative performances of CAR, albumin, and CRP were compared in predicting disease activity (based on FC or Mayo Endoscopic Score) and infliximab trough levels.ResultsIn both the FC (n = 289) and endoscopy (n = 65) cohorts, albumin and CAR correlated with objective disease activity. CAR (area under the curve [AUC] 0.70) was only marginally better at detecting active disease, measured by FC, compared to CRP (AUC 0.68). A CAR >0.15 was able to detect Mayo 3 disease (AUC 0.83, sensitivity 81%, specificity 89%). Albumin (r = 0.38) and CAR (r = −0.42) correlated with infliximab trough levels (n = 204). The optimal CAR for detecting subtherapeutic infliximab trough levels was >0.08 (AUC 0.70, sensitivity 66%, specificity 64%). Both albumin and CAR were independent predictors of subtherapeutic infliximab trough levels but correlated poorly with infliximab trough levels longitudinally in the same patient.ConclusionCAR was only a modest discriminator of subtherapeutic infliximab levels and offers little more than CRP in detecting active disease. CAR has potential to detect severe Mayo 3 disease and could be calculated in patients admitted with suspected acute severe ulcerative colitis.
Genetic variants of unknown significance in alpha‐galactosidase A: Cellular delineation from Fabry disease
Authors: Klein Alexandra , Klug Katharina , Breyer Maximilian , Grüner Julia , Medala Vijay Krishna , Nordbeck Peter , Wanner Christoph , Klopocki Eva , Üçeyler Nurcan 
Published: April 2024

AbstractFabry disease (FD) is an X‐linked multiorgan disorder caused by variants in the alpha‐galactosidase A gene (GLA). Depending on the variant, disease phenotypes range from benign to life‐threatening. More than 1000 GLA variants are known, but a link between genotype and phenotype in FD has not yet been established for all. p.A143T, p.D313Y, and p.S126G are frequent examples of variants of unknown significance (VUS). We have investigated the potential pathogenicity of these VUS combining clinical data with data obtained in human cellular in vitro systems. We have analyzed four different male subject‐derived cell types for alpha‐galactosidase A enzyme (GLA) activity and intracellular Gb3 load. Additionally, Gb3 load in skin tissue as well as clinical data were studied for correlates of disease manifestations. A reduction of GLA activity was observed in cells carrying p.A143T compared with controls (p < 0.05). In cells carrying the p.D313Y variant, a reduced GLA activity was found only in endothelial cells (p < 0.01) compared with controls. No pathological changes were observed in cells carrying the p.S126G variant. None of the VUS investigated caused intracellular Gb3 accumulation in any cell type. Our data of aberrant GLA activity in cells of p.A143T hemizygotes and overall normal cellular phenotypes in cells of p.D313Y and p.S126G hemizygotes contribute a basic science perspective to the clinically highly relevant discussion on VUS in GLA.
Late‐onset refractory hemolytic anemia in siblings treated for methionine synthase reductase deficiency: A rare complication possibly prevented by hydroxocobalamin dose escalation?
Authors: Nguyen Alexandre , Deshayes Samuel , Nowoczyn Marie , Imbard Apolline , Mansour‐Hendili Lamisse , Cesbron Alexandre , Benoist Jean François , Schiff Manuel 
Published: April 2024

AbstractMethionine synthase reductase deficiency (cblE) is a rare autosomal recessive inborn error of cobalamin metabolism caused by pathogenic variants in the methionine synthase reductase gene (MTRR). Patients usually exhibit early‐onset bone marrow failure with pancytopenia including megaloblastic anemia. The latter can remain isolated or patients may present developmental delay and rarely macular dysfunction. Treatment mostly includes parenteral hydroxocobalamin to maximize the residual enzyme function and betaine to increase methionine concentrations and decrease homocysteine accumulation. We report herein 2 cblE siblings diagnosed in the neonatal period with isolated pancytopenia who, despite treatment, exhibited in adulthood hemolytic anemia (LDH >11 000 U/L, undetectable haptoglobin, elevated unconjugated bilirubin) which could finally be successfully treated by hydroxocobalamin dose escalation. There was no obvious trigger apart from a parvovirus B19 infection in one of the patients. This is the first report of such complications in adulthood. The use of LDH for disease monitoring could possibly be an additional useful biomarker to adjust hydroxocobalamin dosage. Bone marrow infection with parvovirus B19 can complicate this genetic disease with erythroblastopenia even in the absence of an immunocompromised status, as in other congenital hemolytic anemias. The observation of novel hemolytic features in this rare disease should raise awareness about specific complications in remethylation disorders and plea for hydroxocobalamin dose escalation.
Salt‐tolerant plant growth‐promoting Pseudomonas atacamensis KSS‐6 in combination with organic manure enhances rice yield, improves nutrient content and soil properties under salinity stress
Authors: Arora Naveen K. , Mishra Jitendra , Singh Pradyumna , Fatima Tahmish 
Published: April 2024

AbstractIn the current study salt tolerant‐plant growth‐promoting rhizobacteria (ST‐PGPR) Pseudomonas atacamensis KSS‐6, selected on the basis of prominent plant growth‐promoting (PGP) and stress tolerance properties was tested as bioinoculant to improve yield of rice grown in saline soil. The ST‐PGPR KSS‐6 was capable of maintaining the PGP traits up to 200 mM NaCl, however, higher salt stress conditions affected these activities. The study was designed to determine the effect of developed talc‐based bioformulation using KSS‐6 along with organic manure (OM) on growth and yield of paddy under saline conditions. Bioformulation broadcasting was also done to examine the effect on soil properties. It was found that the combinatorial treatment showed positive impact on growth and yield of rice under saline conditions. Co‐application of KSS‐6 with OM showed maximum increment in growth, chlorophyll content, plant fresh weight, and dry weight as compared to untreated control plants. Furthermore, the combinatorial treatment improved the nutrient content (P, K, Zn, Fe, Mg, and Mn) by more than 35% and enhanced the biochemical parameters such as proline, flavonoids, carbohydrates, protein, dietary fiber, and antioxidant content of rice grains by more than 32%. Soil parameters including pH and electrical conductivity (EC), moisture content, total organic carbon, OM, sodium, and chloride ions were also improved upon treatment. There was significant lowering of EC from 7.43 to 4.3 dS/m when combination of OM and bacteria were applied. These findings suggest that the application of KSS‐6 in the form of bioinoculant could be a promising strategy to mitigate negative impacts of salt stress and enhance the yield and nutritional properties of rice grown in degraded and saline soil.
Processing effects on bilayer structures formation and rheological behavior of softeners using cationic di(hydrogenated tallow)dimethylammonium chloride aqueous dispersions
Authors: de Castro Nathan V. , Ferreira Guilherme A. , Loh Watson 
Published: April 2024

AbstractThe use of softeners is essential for enhancing laundered fabrics and hair textures after washing. For these, products based on double‐tailed cationic surfactants are used to reduce friction and static electricity, resulting in softer and smoother fibers. These surfactants form lamellar phases in water, which can be turned into vesicles and other bilayer aggregates upon shearing, greatly impacting on the rheological properties of these formulations. This study aims at elucidating how some parameters of the formulation process impact bilayer structures formation and the product rheology, using di(hydrogenated tallow)dimethylammonium chloride (DHTDMAC) aqueous dispersions as model system. Small angle X‐ray scattering (SAXS) analyses revealed lamellar phases starting from 3% DHTDMAC, with a bilayer thickness of 1.90 ± 0.03 nm, indicating significant carbon chain interdigitation. At this concentration (3%), bilayers exhibited a repetition distance of 69 nm, unveiling a behavior close to the one predicted for infinite swelling, in which lamellar structures persisted even at high dilution. Temperature plays a significant role in the rheological behavior, with elevated temperatures favoring vesicle formation, resulting in reduced apparent viscosity due to lower resistance of vesicles to flow. Upon heating, differential scanning calorimetry (DSC) analyses revealed a transition from Lβ (gel) to Lα (fluid) structures between 28 and 41°C, which was further confirmed by X‐ray diffraction (XRD). Both structural and thermotropic features observed were discussed and compared to information reported for a high‐purity grade homologue of DHTDMAC, dioctadecyldimethylammonium chloride (DODAC) mixed with water. These findings deepen the understanding of fabric softener formulation and the impact of bilayer structures formation on their properties, and should be used to optimize new formulations, enhancing their overall performance and sensorial quality.
Improvement of processable properties of plant‐based high internal phase emulsions by mung bean protein isolate based on pH shift treatment
Authors: Wen Luming , Dai Hongmin , Li Sha , Liang Hongshan , Li Bin , Li Jing 
Published: April 2024

AbstractBACKGROUNDHigh internal phase emulsions (HIPEs) are unique emulsion systems that transform liquid oil into solid‐like fats, thus avoiding the use of saturated fat and leading to a healthier and more sustainable food system for consumers. HIPEs with oil volume fraction (ϕ) of 75–85% were fabricated with mung bean protein isolate (MPI) under different pH shift treatments at 1.0% concentration through the one‐step method. In the present study, we investigated the physical properties, microstructures, processing properties, storage stability and rheological properties of HIPEs.RESULTSThe results suggested that the properties of MPI under different pH shift treatments were improved to different degrees, stabilizing HIPEs (ϕ = 75–85%) with various processability to meet food processing needs. Under alkali shift treatment conditions, the particle size of MPI was significantly reduced with better solubility. Moreover, the exposure of hydrophobic groups increased the surface hydrophobicity of MPI, awarding MPI better emulsifying properties, which could stabilize the HIPEs with higher oil phase fraction. In addition, the MPI under pH 12 shift treatment (MPI‐12) had the best oil‐carrying ability to form the stable HIPEs with oil volume fraction (ϕ) up to 85%, which was the highest oil phase in preparing the HIPEs using plant protein solely at a low concentration under neutral conditions.CONCLUSIONA series of stable HIPEs with different processing properties was simply and feasibly fabricated and these are of great potential in applying edible HIPEs. © 2024 Society of Chemical Industry.
Study of Lactobacillus plantarum coated with Tremella polysaccharides to improve its intestinal adhesion
Authors: Zhu Yeli , Tang Fuhao , Wang Yihan , Li Bingbing , Teng Jianwen , Huang Li , Xia Ning 
Published: April 2024

AbstractBACKGROUNDThe adhesion of probiotics to the intestine is crucial for their probiotic function. In previous studies, Tremella polysaccharides (TPS) (with sodium casein) have shown the potential to encapsulate probiotics and protect them in a simulated gastrointestinal tract. This study explored the effect of TPS (with sodium casein) on the adhesion of probiotics.RESULTSLactobacillus plantarum was coated with TPS and sodium casein in different proportions, and was freeze‐dried. The rheological properties of the mixture of probiotics powder and mucin solution were determined by static and dynamic rheological analysis. Aqueous solutions of probiotic powder and mucin mixture exhibited pseudoplastic fluid rheological properties. The higher the proportion of TPS content, the higher the apparent viscosity and yield stress. The mixed bacterial powder and mucin fluid displayed thixotropy and was in accordance with the Herschel–Bulkley model. The TPS increased the bio‐adhesive force of the probiotic powder and mucin. When using TPS as the only carbon source, the adhesion of L. plantarum to Caco‐2 cells increased by 228% in comparison with glucose in vitro. Twelve adhesive proteins were also detected in the whole‐cell proteome of L. plantarum. Among them, ten adhesive proteins occurred abundantly when grown with TPS as a carbon source.CONCLUSIONTremella polysaccharides therefore possess probiotic properties and can promote the intestinal adhesion of L. plantarum. © 2024 Society of Chemical Industry.
Adverse childhood experiences, individual‐level risk and protective factors, and recent drug use in a community sample of Nigerian women
Authors: Agwogie Martin Osayande , Kliewer Wendy , Ibrahim Muhammed Bashir 
Published: April 2024

AbstractAdverse childhood experiences (ACEs) are associated with a wide range of health problems and health‐compromising behaviors, including drug use, but are understudied in sub‐Saharan Africa. Further, some data suggest that some types of ACEs are more strongly associated with outcomes than others. We investigated associations between different types of ACEs and recent drug use among 2,011 women living in Katsina State, Nigeria. This community‐based survey included questions on ACE exposure, modifiable individual‐level risk and promotive factors, and past‐year drug use. Tobacco, cannabis, and the nonmedical use of cough syrup with codeine and tramadol were the most frequently used drugs. Logistic regressions revealed that across most drugs, ACEs reflecting abuse, neglect, and household dysfunction, but not community violence, increased the likelihood of drug use, odds ratios (ORs) = 1.30–3.10. Ease of access to drugs, ORs = 1.33–2.98, and personal religiosity, ORs = 1.19–2.27, also enhanced the risk of drug use, and higher depressive affect was associated with codeine, OR = 1.27, and tramadol use, ORs = 2.42. Practicing religious rites, ORs = 0.38–0.70; disapproval of drug use, ORs = 0.36–0.57; and perceived harm from drug use, ORs = 0.54–0.71, reduced the likelihood of drug use. Efforts to prevent abuse, neglect, and household dysfunction; reduce access to drugs; treat depression; and increase disapproval and harm associated with drug use may reduce drug use in the context of ACE exposure.