bluuebunny/crossref_metadata_2025_split huggingface dataset:
No major impact of new grape varieties on Bordeaux wine typicity: expert assessments in blind and non-blind tastings
Authors: Plantevin Marc , Tempère Sophie , Thibon Cécile , Dijkstra Lucile , Lecourt Julien , Destrac-Irvine Agnès , Van Leeuwen Cornelis 
Published: February 2025

Climate change induces major changes in wine typicity due to its impact on berry composition at harvest. This is of great concern for winegrowing regions historically renowned for their terroir and quality potential. Among different levers to adapt to climate change, the modification of grape varieties is considered to be very effective. However, this powerful tool can have repercussions for the protection of the region of origin’s wine typicity. In Bordeaux (France), a considerable research effort addresses the physiological traits of new varieties to thrive in a climate becoming increasingly dry and warm. Recently, a study investigating the typicity of 26 red varieties isolated five potential candidates (Fer Servadou, Duras, Manseng noir, Vinhão and Arinarnoa) sharing similar sensorial spaces compared to classical Bordeaux varieties. Varietal mix is strictly regulated by protected denomination of origin (PDO) rules, although these can change over time. If new varieties were to be accepted in the Bordeaux varietal mix, it would most likely be as secondary varieties accounting for a small proportion in the final Bordeaux blend. This study aimed to assess the impact of the five abovementioned varieties when incorporated into a classical Bordeaux blend (i.e., Cabernet-Sauvignon, Merlot, Cabernet franc and Petit Verdot), at a proportion of 10 % and 30 % respectively. Two sensory analysis tests were conducted within a two-month period. The first one, which included 37 professional judges, showed that Bordeaux wine typicity barely changed when these varieties were introduced at 10 % or 30 %, except for Vinhão that underwent a slight typicity decrease. The second sensory analysis test was conducted by 20 highly professional judges with an exceptional degree of expertise (> 15 years of experience), especially in blending. Assessing the wines through both blind and non-blind tastings (indication of the varieties present in the blend), the importance of the information on the typicity judgment was assessed. No significant differences were recorded between non-blind and blind tastings, showing that the perceptual judgement of the highly-experienced professionals was not influenced by the introduction of the new varieties to the classical blend. By means of ranking tests, this sensory analysis also showed that the Bordeaux reference blend was the most typical of the wines. Duras and Arinarnoa at 10 or 30 % had a non-significant effect on the blend’s typicity, while a significant decrease of typicity was observed when Fer Servadou (at 10 % or 30 %), Manseng noir (at 30 %) or Vinhão (at 30 %) were introduced to the Bordeaux reference blend. This shift of typicity only occurs, however, on a tight continuum of less to more typical wines.
Practicing Religious Moderation among Muslims, Buddhists, and Hindus in North Lombok
Authors: Jayadi Suparman , Ridho Abdul Rasyid 
Published: February 2025

<p>Diversity in recent times has its challenges, especially maintaining social harmony in the midst of potential religious conflicts. The practice of religious moderation is very important in fostering tolerance and peace between religions. This article aims to explore and implement the practice of religious moderation among the Muslim, Buddhist and Hindu communities in Juara Timur Village, North Lombok, Indonesia, with a focus on Pujawali rituals as a case study. This article uses qualitative methods to present field data, by conducting observations, then in-depth interviews with informants related to values and norms in religious moderation practices, and conducting documentation. The findings of this study show that community adherence to local traditions and mutual respect for different religious practices can make a significant contribution to maintaining social cohesion. The practice of Pujawali Ritual is an example of how interfaith interaction based on local wisdom and cultural practices can increase social solidarity and religious comfort and security to date. This study contributes to the importance of values and norms in the practice of religious moderation to realize peace and prevent social conflicts and can be used as a role model in various regions in Indonesia.</p>
Race-based differences in serum biomarkers for cancer-associated cachexia in a diverse cohort of patients with pancreatic ductal adenocarcinoma
Authors: Permuth Jennifer , Park Margaret , Davis Evan , Alhassan Solomon , Arnoletti J. , Basinski Toni , McKee Ashley , Bloomston Mark , Carson Tiffany , de Castria Tiago Biachi , Chen Dung-Tsa , Cortizas Elena , Crowder Sylvia , Delgado Maria Genilo , Douglas Wade , Fleming Jason , Hodul Pamela , Huguet Kevin , Jiang Kun , Kim Dae Won , Koomen John , Luthra Anjuli , Malafa Mokenge , Menon Anjana , Morales Raiza , Merchant Nipun , Meredith Kenneth , Mo Qianxing , Molina-Vega Manual , Moreno-Urazan Lina , Olumoyin Kayode , Parker Nathan , Pimiento Jose , Rasool Ghulam , Rejniak Katarzyna , Sansil Samer , Sparks Lauren , Stewart Paul , Tassielli Alexandra , Teer Jamie , Tran Dan Viet , Trevino Jose , Velanovich Vic , Whelan Christopher , Jeong Daniel , Judge Sarah , Judge Andrew 
Published: February 2025

Abstract

Pancreatic ductal adenocarcinoma is projected to become the second leading cause of cancer-related deaths by 2040, with the highest disease burden expected amongst Non-Hispanic Blacks. One of the most significant predictors of poor outcomes is the presence of cancer-associated cachexia (CCa). Yet, race- and ethnicity-specific biomarkers for early CCa diagnosis are lacking. Thus, evaluated a panel of candidate biomarkers of CCa in a diverse cohort of pre-treatment serum. Our study shows that GDF-15 was associated with cachexia severity, was superior to standard CCa-associated biomarkers at classifying cachexia, and differentiated between non-cachexia and pre-cachexia status, but only among Hispanic/Latinx and non-Hispanic Whites. Furthermore, high GDF-15 levels at diagnosis were associated with a ~ 2-fold increase in weight loss over the 6 months post-diagnosis. Thus, GDF-15 may be a potential biomarker for pre-cachexia (prior to weight loss) in the White and the Hispanic population, but not Black individuals. These findings underscore the fact that enrollment of minority individuals in clinical trials to evaluate treatments for CCa is of utmost importance.
Reevaluating the Role of Education in Cognitive Decline and Brain Aging: Insights from Large-Scale Longitudinal Cohorts across 33 Countries
Authors: Fjell Anders , Rogeberg Ole , Sørensen Øystein , Amlien Inge , Bartres-Faz David , Brandmaier Andreas , Cattaneo Gabriele , Duzel Sandra , Grydeland Håkon , Henson Rik , Kühn Simone , Lindenberger Ulman , Lyngstad Torkild , Mowinckel Athanasia , Nyberg Lars , Pascual-Leone Alvaro , Sole-Padulles Cristina , Sneve Markus , Solana Javier , Stromstad Marie , Watne Leiv , Walhovd Kristine Beate , Vidal Didac 
Published: February 2025

Abstract

Why education is linked to higher cognitive function in aging is fiercely debated. Leading theories propose that education reduces brain decline in aging, enhances tolerance to brain pathology, or that it does not affect cognitive decline but rather reflects higher early-life cognitive function. To test these theories, we analyzed 407.356 episodic memory scores from 170.795 participants > 50 years, alongside 15.157 brain MRIs from 6.472 participants across 33 Western countries. More education was associated with better memory, larger intracranial volume and slightly larger volume of memory-sensitive brain regions. However, education did not protect against age-related decline or weakened effects of brain decline on cognition. The most parsimonious explanation for the results is that the associations reflect factors present early in life, including propensity of individuals with certain traits to pursue more education. While education has numerous benefits, the notion that it provides protection against cognitive or brain decline is not supported.
Prediction of Residual Disease After Excisional Procedure: a Comparison Between Endocervical Curettage and Surgical Margins Following Transformation Zone Excision
Authors: Dias Zinia , de Oliveira Marina , Tricoti Alessandra , Junior João Carlos , Drumond Denise , Leite Isabel 
Published: February 2025

Abstract

PURPOSE: Human Papillomavirus (HPV) is responsible for precursor lesions of cervical cancer, which must be treated through excision of the transformation zone (ETZ). Following the procedure, it is crucial to identify residual lesions in the remaining cervix. Currently, the standard evaluation involves assessing the pathological involvement of surgical margins in the ETZ specimen. This study aims to evaluate the agreement on the presence of residual disease by comparing histopathological results of surgical margins from the excisional procedure with material obtained from endocervical curettage (ECC) post ETZ.
METHODS: A census-based study was conducted, including patients from the gynecology service of a public university hospital between 2022 and 2024. The association between diagnostic methods was assessed using the Kappa test. Sociodemographic and gynecological-obstetric characteristics were compared with results indicative of residual disease from both methodologies. Associations between variables were analyzed using bivariate methods with a 95% confidence interval.
RESULTS: Total of 120 patients participated, with mean age of 40 years, predominantly diagnosed with CIN II+. Surgical margin involvement was detected in 27.9% of cases, and ECC positivity in 10%, with four ECC-positive cases showing negative surgical margins, suggesting potential false negatives in the current standard analysis. The sensitivity of ECC was 0.21; specificity, 0.95; negative predictive value, 0.76; and positive predictive value, 0.6. There was weak agreement between diagnostic methods (Kappa 0.197). Only skin color was associated with surgical margin positivity (p-value 0.046).
CONCLUSION: Post-ETZ ECC can provide complementary information regarding surgical margin involvement in patients undergoing excisional procedures.
Combining forced limb use with Ninjin'yoeito treatment prevents atrophy in fast-twitch muscles and promotes functional restoration after hemorrhagic stroke in rat models
Authors: Tajiri Naoki , Ueno Shinya , Mustika Dewi , Tominaga Shiori , Shimizu Takeshi , Mizuno Keita , Hida Hideki 
Published: February 2025

Abstract

Rehabilitative training incorporating forced limb use (FLU) following intracerebral hemorrhagic stroke (ICH) enhances functional recovery of skilled reaching in rats. Given that Ninjin'yoeito (NYT) influences both cerebral and muscular systems, this study aimed to investigate whether the combined application of FLU and NYT could yield superior functional recovery compared to FLU alone. The ICH model was established by collagenase injection, and the subject was administered FLU from day 1 after ICH (D1) for 7 days and 1% NYT chow until D56. The combination of FLU and NYT resulted in significantly enhanced functional recovery in motor deficit scores at D28 and D56 compared with ICH only, although the score was comparable to that of the FLU group. The combination group exhibited increased total walking distance and a higher number of center entrances in the open-field test at D28. Retrograde labeling of corticospinal neurons after ICH with FluoroGold (FG) revealed no significant increase in FG-positive cells in the cortex of the combination group compared to the FLU group. Anterograde labeling with biotinylated dextran amine demonstrated increased bouton-like varicosities in the red nucleus, similar to that in the FLU group, although NYT alone did not increase the number of positive cells. Specific atrophy of MHC IIb-positive muscles after ICH was mitigated in the combination group, although no significant changes were observed in either the FLU or NYT groups. These findings indicate that the combination of FLU and NYT contributes to the functional recovery of FLU following ICH, mitigating atrophy of fast-twitch muscles.
Bidirectional Causality in IBD and Periodontitis: Insights from Mendelian Randomization and Bioinformatics
Authors: Gu Zhongyi , Gao Aichao , Ma Xiang , Wang Xiaotong , Qiu Caiqing 
Published: February 2025

Abstract

Background
The causal relationship between inflammatory bowel disease (IBD) and periodontitis remains a topic of debate. This study aimed to assess the causal relationship between the two.
Methods
This study employed a bidirectional Mendelian randomization (MR) analysis combined with integrated bioinformatics. On one hand, it explored the causal relationship between IBD and periodontitis using bidirectional MR analysis, with inverse variance weighting (IVW) as the judgment basis and conducted sensitivity analysis. On the other hand, it utilized RNA sequencing data to mine the co-expressed differential genes between the two diseases, to explore the common inflammatory molecules and potential molecular signaling pathways between them.
Results
The study found a bidirectional causal link between IBD and periodontitis (P < 0.05), with the sensitivity analysis showing consistency and no significant heterogeneity or pleiotropy (P > 0.05). The results of the MR analysis further confirmed the causal relationship between them. The integrated bioinformatics analysis indicated that immune-related factors, represented by IL1B and CXCR4, and signaling pathways, notably TNF and IL17, may play an important role in the progression of both diseases.
Conclusion
This study, through Mendelian Randomization analysis, established a mutual causal relationship between IBD and periodontitis. The transcriptome sequencing data analysis revealed the common pathological mechanisms and the role of key immune regulatory factors in these diseases. These findings provide important scientific basis for the diagnosis and treatment of IBD and periodontitis, emphasizing the importance of a deep understanding of the interaction between these diseases.
Perceptions and Attitudes of Mental Health Professionals Towards Suicidal Behavior Cases: A Cross-Sectional Qualitative Study
Authors: GASHUGI Yves , Kanyana Ernestine , Sebatukura Simeon Gitimbwa , Izabayo Josias , Kisakye Josephine 
Published: February 2025

Abstract

Aims: This study aims to examine the attitudes and perceptions of Mental health Professionals toward suicidal behavior cases.
Background: Suicide remains a significant public health challenge worldwide, particularly in low- and middle-income countries. In Rwanda, suicide rates have increased due to a combination of psychological, social, cultural, and economic factors. Mental health professionals (MHPs) play a critical role in suicide prevention, yet their perceptions, attitudes, and coping mechanisms remain underexplored. This study investigates MHPs’ perspectives on recognizing suicidal behavior, identifying risk factors, and managing the emotional burden associated with suicide prevention.
Methods: A qualitative, cross-sectional study was conducted using semi-structured interviews with 12 mental health professionals working in various institutions across Rwanda. Participants were selected through purposive sampling. Data collection involved both in-person and virtual interviews, with thematic analysis applied to identify recurring themes in MHPs’ experiences, attitudes, and coping strategies. Ethical considerations, including informed consent and confidentiality, were strictly adhered to.
Results: Findings reveal that MHPs identify hopelessness, social withdrawal, somatic complaints, and verbalized suicide intent as primary indicators of suicide risk. Family conflict, mental illness, economic distress, and genocide-related trauma were cited as major contributing factors. MHPs reported experiencing guilt, frustration, countertransference, and burnout when working with suicidal patients. However, coping mechanisms such as spiritual practices, social support, clinical supervision, and physical activities were commonly employed to manage emotional distress.
Conclusion: Addressing stigma, improving training in suicide risk assessment, expanding mental health services, and enhancing professional support systems are critical for strengthening suicide prevention efforts. Implementing evidence-based interventions and community-focused mental health strategies can improve outcomes for at-risk individuals and reduce the emotional burden on MHPs.
Genome-wide mapping of complement system proteins for islet autoimmunity in the DAISY and TEDDY children
Authors: Hu Xiaowei , Webb-Robertson Bobbie-Jo M , Parikh Hemang M , Nakayasu Ernesto S , Onengut-Gumuscu Suna , Chen Wei-Min , Frazer-Abel Ashley , Metz Thomas O , Rich Stephen S , Rewers Marian J , Manichaikul Ani 
Published: February 2025

Abstract

Background
Type 1 diabetes (T1D) is characterized by the autoimmune destruction of the insulin-producing beta cells, and there is no cure yet for the disease. While islet autoantibodies are well-recognized biomarkers that mark the onset of islet autoimmunity (IA) and are predictors of T1D, few additional biomarkers are available to monitor disease progression. Recent studies have reported the involvement of complement system proteins in the initiation and progression of IA in the study of T1D. However, the genetic factors of complement system proteins at the time of triggering of IA is unknown.
Results
Through complement system protein quantitative trait locus (pQTL) mapping analysis of 170 participants from the Diabetes Autoimmunity Study in the Young (DAISY), we identified 240 statistically significant pQTLs (false discovery rate, FDR < 0.1) from pooled and IA case-stratified analyses. Replication analysis conducted on 385 IA cases from The Environment Determinants of Diabetes in the Young (TEDDY) study confirmed 68 significant (FDR < 0.05) pQTLs in total for C8A, C8B, CFB, C4A, and MBL2. Furthermore, all replicated pQTLs of CFB and C4A were previously reported to be associated with T1D risk.
Conclusions
We identified and replicated 68 pQTLs for five complement system proteins (C8A, C8B, CFB, C4A, and MBL2) in the young population. Among them, all replicated pQTLs of CFB and C4A are also associated with T1D risk. Our study provides evidence of complement system proteins as potential protein biomarkers underlying the development and progression of T1D.
Chitosan and copper nanoparticles in vase solutions elevate the quality and longevity of cut tulips, setting a new standard for sustainability in floriculture.
Authors: Othman Eman Z. , El-Ziat Rasha A. ,   Iman M. El-Sayed2
Published: February 2025

Abstract

Nanoparticles offer innovative solutions for postharvest applications, allowing for the development of innovative compounds that effectively extend the shelf life of cut flowers by reducing ethylene production and preventing bacterial growth. Tulips as a leading choice among cut flowers, encounter common issues such as neck bending and a limited display life, which can severely impact their marketability. This experiment aims to evaluate the effectiveness of nano chitosan (CHS-NPs) at 3.5 and 7.0 mg L− 1, nano copper (Cu-NPs) at 15 and 30 mg L− 1, and lemongrass essential oil (LG) at 150 and 300 mg L− 1 as innovative, eco-friendly solutions for improving the quality and extending the shelf life of cut tulip flowers. The findings reveal that CHS-NPs and Cu-NPs significantly prolong the vase life of cut tulip flowers, with optimal concentrations determined to be 7.5 mg L− 1 and 30 mg L− 1, respectively. These treatments not only enhance water uptake and relative fresh weight (RFW%) but also effectively inhibit microbial growth at the stem base and prevent bacterial blockages in the xylem for up to seven days. Moreover, they substantially increase chlorophyll levels, total soluble carbohydrates, and proteins while decreasing hydrogen peroxide (H2O2) production and boosting antioxidant enzyme activity, thereby enhancing membrane stability. In conclusion, CHS-NPs at 7.5 mg L− 1 and Cu-NPs at 30 mg L− 1 significantly enhance the vase life of cut tulips by improving water balance and antioxidant activity, with Cu-NPs demonstrating better effectiveness. The adoption of Cu-NPs at the recommended concentration should be prioritized in the tulip floral industry.
Size and Microstructure Effect of Silica Nanosphere Assemblies on Antireflective Capability of Typical Solar Cells
Authors: Geints Yury E. 
Published: February 2025

Abstract

This work addresses the problem of broadband optical scattering by micro-assemblies of submicron silica spherical particles functioning as an antireflective (AR) coating applied to the outer layer of a typical solar cell. Using full-wave electromagnetic simulations based on the finite element method, we conduct numerical investigations of the near-field spatial distribution in the vicinity of such micro-assemblies with different internal microstructures. The assemblies can be either fully ordered or possess a disordered nanotexture formed by the random packing of multiple silica nanospheres (NSs). The primary objective of our research is to evaluate the efficiency of light transmission through the surface layer of a solar cell depending on the structural design of the NS-based AR coating. We show that the minimization of unwanted optical reflection of incident radiation is achieved across the entire spectral range of solar radiation at various angles of incidence by using AR coatings composed of essentially subwavelength NSs arranged in a specific number of ordered (densely packed) or disordered (sparsely packed) consecutive layers, which depends on the substrate optical properties.
A method for Symbol Resolution
Authors: Milivojevic Sinisa 
Published: February 2025

Abstract

This paper provides the result of an extensive research into a novel set of algorithms that would provide more efficient (and faster) manner of resolving symbols, such as reserved words, keywords, operators, functions and similar. A new method has been provided which has been thoroughly tested. That method required the utilisation of the hashing. Many hashes have been tested, of which only few could render required results. This resulted in the the invention and development of new hashes, by the author. All necessary information from this research is presented including characteristics of some known algorithms, and including the efficiency of the utilised hashes and a total speed of execution for the entire set of symbols on two different CPUs.