bluuebunny/crossref_metadata_2025_split huggingface dataset:
Commanding the Queen
Authors: Brownsmith Esther 
Published: April 2024

Abstract
The gendered lines between direct and indirect agency blur in the book of Esther, in line with its ‘topsy-turvy’ carnivalesque attitude. Queen Esther acts with direct agency (the power to command her fellow Jews, then accusing Haman of treachery), while her cousin Mordecai gains power indirectly (through his relationship with Esther and through the knowledge he gains from listening to eunuchs) and is threatened with death when he attempts to exercise more direct agency. These reversals of expectations can be connected with the Bem Sex Role Inventory (BSRI), an influential twentieth century set of descriptors that link certain psychological traits to masculinity or femininity—with most of the words associated with direct agency in the ‘masculine’ category. One could simply conclude that the Book of Esther is blurring gender lines, but an intersectional perspective reveals more at stake: the Book of Esther demonstrates that the power dynamics that dictate who can have direct agency do not always align with gender. This forces us to re-examine metrics like the BSRI for how they reflect existing power roles rather than inherent tendencies. Is direct agency inherently masculine, or just something that men have had more capacity to exercise? The complicated dynamics of the Book of Esther bring this question into focus, without offering a clear-cut answer.
“Asia for Asians”: Revisiting Pan-Asianism through the Propaganda Arts of the Greater East Asia Co-Prosperity Sphere
Authors: Magpantay Andre 
Published: April 2024

Abstract
The slogan “Asia for Asians” has been a central concept of the Greater East Asia Co-Prosperity Sphere and propagated by Japan as it imperialized parts of East Asia, Southeast Asia, South Asia, and Oceania. Without bias to the resulting historical developments and realities, Pan-Asianism is revisited through the propaganda arts and materials proliferated by the Empire of Japan towards its agenda of a unified Asia. Aided by knowledge of art history and criticism, six specifically chosen propaganda arts are analyzed using theories of image analysis drawing from the works of Guillermo (2001), Bartmański, Alexander, and Giesen (2012), and Ross (2002). Three main themes are analyzed: the image of the sphere, the collective identity of the countries in the sphere under Japan, and the meaning of co-prosperity. The themes provide an insight into the development of Pan-Asianism as propagated by the Japanese Empire in its attempt towards Pan-Asianism through the Greater East Asia Co-Prosperity Sphere.
Western North Pacific Monsoon Vorticity Distribution as a Potential Driver of Interannual Meridional Migration of the Boreal Summer Synoptic-Scale Wave Train
Authors: Chen Shaohua , Zhao Haikun , Klotzbach Philip J. , Cao Jian , Liang Jia , Zhou Weican , Wu Liguang 
Published: April 2024

Abstract
On interannual time scales, there is significant meridional migration of the boreal summer (May–October) synoptic-scale wave (SSW) train relative to the summer monsoon trough line over the western North Pacific (WNP) during 1979–2021. The associated plausible physical reasons for the SSW meridional migration are investigated by comparing analyses between two distinct groups: atypical SSW years where SSWs tend to prevail northward of the summer monsoon trough line and typical SSW years where SSWs largely occur along the summer monsoon trough line. During typical SSW years, SSWs originate primarily from equatorial mixed Rossby-gravity (MRG) waves and then develop into off-equatorial tropical depression (TD) waves in the lower troposphere of the monsoon region. During atypical SSW years, SSWs appear to be sourced from upper-level easterlies, propagating downward to the lower troposphere in the monsoon region, with a prevailing TD wave structure. A budget analysis of barotropic eddy kinetic energy suggests that interannual meridional SSW migration is closely related to changes in the vorticity distribution along the summer monsoon trough over the WNP, especially the western part of the summer monsoon trough. These changes cause low-frequency zonal convergence and shear differences, changing barotropic conversion around the monsoon trough and modulating interannual SSW meridional movement. In response to these changes, there are corresponding differences in SSW sources: a predominate MRG–TD wave pattern in typical SSW years and a predominate TD wave pattern in atypical SSW years. These results improve our understanding of the interannual variability of large-scale circulation and tropical cyclones.
Intestinal cell diversity and treatment responses in a parasitic nematode at single cell resolution
Authors: Tyagi Rahul , Rosa Bruce A , Swain Amanda , Artyomov Maxim N , Jasmer Douglas P , Mitreva Makedonka 
Published: April 2024

Abstract
Background
Parasitic nematodes, significant pathogens for humans, animals, and plants, depend on diverse organ systems for intra-host survival. Understanding the cellular diversity and molecular variations underlying these functions holds promise for developing novel therapeutics, with specific emphasis on the neuromuscular system’s functional diversity. The nematode intestine, crucial for anthelmintic therapies, exhibits diverse cellular phenotypes, and unraveling this diversity at the single-cell level is essential for advancing knowledge in anthelmintic research across various organ systems.

Results
Here, using novel single-cell transcriptomics datasets, we delineate cellular diversity within the intestine of adult female Ascaris suum, a parasitic nematode species that infects animals and people. Gene transcripts expressed in individual nuclei of untreated intestinal cells resolved three phenotypic clusters, while lower stringency resolved additional subclusters and more potential diversity. Clusters 1 and 3 phenotypes displayed variable congruence with scRNA phenotypes of C. elegans intestinal cells, whereas the A. suum cluster 2 phenotype was markedly unique. Distinct functional pathway enrichment characterized each A. suum intestinal cell cluster. Cluster 2 was distinctly enriched for Clade III-associated genes, suggesting it evolved within clade III nematodes. Clusters also demonstrated differential transcriptional responsiveness to nematode intestinal toxic treatments, with Cluster 2 displaying the least responses to short-term intra-pseudocoelomic nematode intestinal toxin treatments.

Conclusions
This investigation presents advances in knowledge related to biological differences among major cell populations of adult A. suum intestinal cells. For the first time, diverse nematode intestinal cell populations were characterized, and associated biological markers of these cells were identified to support tracking of constituent cells under experimental conditions. These advances will promote better understanding of this and other parasitic nematodes of global importance, and will help to guide future anthelmintic treatments.
Evolutionary genetics of pulmonary anatomical adaptations in deep-diving cetaceans
Authors: Guo Boxiong , Sun Yixuan , Wang Yuehua , Zhang Ya , Zheng Yu , Xu Shixia , Yang Guang , Ren Wenhua 
Published: April 2024

AbstractBackgroundCetaceans, having experienced prolonged adaptation to aquatic environments, have undergone evolutionary changes in their respiratory systems. This process of evolution has resulted in the emergence of distinctive phenotypic traits, notably the abundance of elastic fibers and thickened alveolar walls in their lungs, which may facilitate alveolar collapse during diving. This structure helps selective exchange of oxygen and carbon dioxide, while minimizing nitrogen exchange, thereby reducing the risk of DCS. Nevertheless, the scientific inquiry into the mechanisms through which these unique phenotypic characteristics govern the diving behavior of marine mammals, including cetaceans, remains unresolved.ResultsThis study entails an evolutionary analysis of 42 genes associated with pulmonary fibrosis across 45 mammalian species. Twenty-one genes in cetaceans exhibited accelerated evolution, featuring specific amino acid substitutions in 14 of them. Primarily linked to the development of the respiratory system and lung morphological construction, these genes play a crucial role. Moreover, among marine mammals, we identified eight genes undergoing positive selection, and the evolutionary rates of three genes significantly correlated with diving depth. Specifically, theSFTPCgene exhibited convergent amino acid substitutions. Through in vitro cellular experiments, we illustrated that convergent amino acid site mutations in SFTPC contribute positively to pulmonary fibrosis in marine mammals, and the presence of this phenotype can induce deep alveolar collapse during diving, thereby reducing the risk of DCS during diving.ConclusionsThe study unveils pivotal genetic signals in cetaceans and other marine mammals, arising through evolution. These genetic signals may influence lung characteristics in marine mammals and have been linked to a reduced risk of developing DCS. Moreover, the research serves as a valuable reference for delving deeper into human diving physiology.
London Protocol under water-perfused HRM in a healthy population, towards novel 3D manometric parameters in an evaluation of anorectal functional disorders
Authors: Anefalos Alexandre , Martinez Carlos Augusto Real , Coy Claudio Saddy Rodrigues 
Published: April 2024

Abstract
Background/Aim
London Protocol (LP) and Classification allied to high-resolution manometry (HRM) technological evolution has updated and enhanced the diagnostic armamentarium in anorectal disorders. This study aims to evaluate LP reproducibility under water-perfused HRM, provide normal data and new parameters based on 3D and healthy comparison studies under perfusional HRM.

Methods
Fifty healthy (25 F) underwent water-perfused 36 channel HRM based on LP at resting, squeeze, cough, push, and rectal sensory. Additional 3D manometric parameters were: pressure-volume (PV) 104mmHg2.cm (resting, short and long squeeze, cough); highest and lowest pressure asymmetry (resting, short squeeze, and cough). Complementary parameters (CP) were: resting (mean pressure, functional anal canal length); short squeeze (mean and maximum absolute squeeze pressure), endurance (fatigue rate, fatigue rate index, capacity to sustain); cough (anorectal gradient pressure); push (rectum-anal gradient pressure, anal canal relaxation percent); recto-anal inhibitory reflex (anal canal relaxation percent).

Results
No difference to genders: resting (LP, CP, and 3D); short squeeze (highest pressure asymmetry); endurance (CP); cough (CP, highest and lowest pressure asymmetry); push (gradient pressure); rectal sensory. Higher pressure in men: short squeeze (maximum incremental, absolute, and mean pressure, PV, lowest pressure asymmetry); long squeeze (PV); cough (anal canal and rectum maximum pressure, anal canal PV); push (anal canal and rectum maximum pressure). Anal canal relaxation was higher in women (push).

Conclusions
LP reproducibility is feasible under water-perfused HRM, and comparative studies could bring similarity to dataset expansion. Novel 3D parameters need further studies with healthy and larger data to be validated and for disease comparisons.

Key points
• London Protocol and Classification allied with the technological evolution of HRM (software and probes) has refined the diagnostic armamentarium in anorectal disorders.
• Novel 3D and deepening the analysis of manometric parameters before the London Classification as a contributory diagnostic tool.
• Comparison of healthy volunteers according to the London Protocol under a perfusional high-resolution system could establish equivalence points.
The association between restricted activity and patient outcomes in older adults: systematic literature review and meta-analysis
Authors: Henderson Ishbel L. , Bone Rory W. , Stevens Richard , Barnes Rebecca K. , Roberts Nia , Sheppard James P. , McManus Richard J. 
Published: April 2024

Abstract
Background
Restricted activity is a potential early marker of declining health in older adults. Previous studies of this association with patient outcomes have been inconclusive. This review aimed to evaluate the extent to which restricted activity is associated with decline in health.

Methods
A search was conducted for studies including people over 65 years old which investigated the association between measures of restricted activity and hospitalisation, cognitive decline, and mortality. Following data extraction by two reviewers, eligible studies were summarised using Inverse Variance Heterogeneity meta-analysis.

Results
The search identified 8,434 unique publications, with 11 eligible studies. Three measures of restricted activity were identified: bed rest, restricted movement, and dependency for activities of daily living (ADL). Three studies looked at hospitalisations, with two finding a significant association with bed rest or restricted movement and one showing no evidence of an association. Restricted activity was associated with a significant increase in mortality across all three measures (bed rest odds ratio [OR] 6.34, 95%CI 2.51–16.02, I2 = 76%; restricted movement OR 5.38 95%CI 2.60–11.13, I2 = 69%; general ADL dependency OR 4.65 95%CI 2.25–9.26, I2 = 84%). The significant heterogeneity observed could not be explained by restricting the analysis by length of follow-up, or measure of restricted activity. No meta-analysis was conducted on the limited evidence for cognitive decline outcomes.

Conclusions
Limited studies have considered the prognostic value of restricted activity in terms of predicting future declining health. Current evidence suggests restricted activity is associated with hospitalisation and mortality, and therefore could identify a group for whom early intervention might be possible.
Influence of chronic medical conditions on older patients’ willingness to deprescribe medications: a cross-sectional study
Authors: Pereira Anabela , Veríssimo Manuel , Ribeiro Oscar 
Published: April 2024

Abstract
Background
Aging correlates with a heightened prevalence of chronic diseases, resulting in multimorbidity affecting 60% of those aged 65 or older. Multimorbidity often leads to polypharmacy, elevating the risk of potentially inappropriate medication (PIM) use and adverse health outcomes. To address these issues, deprescribing has emerged as a patient-centered approach that considers patients’ beliefs and attitudes toward medication and reduces inappropriate polypharmacy in older adults. Our study aims to investigate whether certain chronic medical conditions are associated with older patients’ willingness to deprescribe medications.

Methods
A cross-sectional study enrolled 192 community-dwelling individuals aged 65 or older taking at least one regular medication. Data included demographics, clinical characteristics, and responses to the Portuguese revised Patients’ Attitudes Towards Deprescribing (rPATD) questionnaire. Descriptive statistics characterized participants, while multiple binary logistic regression identified associations between chronic medical conditions and willingness to deprescribe.

Results
Among the participants (median age: 72 years, 65.6% female), 91.6% had multimorbidity. The analysis revealed that willingness to deprescribe significantly increased with the presence of gastric disease (adjusted odds ratio [aOR] = 4.123; 95% CI 1.221, 13.915) and age (aOR = 1.121; 95% CI 1.009, 1.246). Conversely, prostatic pathology (aOR = 0.266; 95% CI 0.077, 0.916), higher scores in the rPATD appropriateness factor (aOR = 0.384; 95% CI 0.190, 0.773), and rPATD concerns about stopping factor (aOR = 0.450; 95% CI 0.229, 0.883) diminished patients’ willingness to deprescribe.

Conclusions
This study highlights the intricate relationship between older patients’ attitudes toward deprescribing and chronic medical conditions. We found that gastric disease was associated with an increased willingness to deprescribe medications, while prostate disease was associated with the opposite effect. Future research should explore how patients with specific diseases or groups of diseases perceive deprescribing of medications general and for specific medications, aiding in the development of targeted interventions.
Optimization of a mouse model of pancreatic cancer to simulate the human phenotypes of metastasis and cachexia
Authors: Spadafora Victoria , Pryce Benjamin R. , Oles Alexander , Talbert Erin E. , Romeo Martin , Vaena Silvia , Berto Stefano , Ostrowski Michael C. , Wang David J. , Guttridge Denis C. 
Published: April 2024

Abstract
Background
Pancreatic ductal adenocarcinoma (PDAC) presents with a high mortality rate. Two important features of PDAC contribute to this poor outcome. The first is metastasis which occurs in ~ 80% of PDAC patients. The second is cachexia, which compromises treatment tolerance for patients and reduces their quality of life. Although various mouse models of PDAC exist, recapitulating both metastatic and cachectic features have been challenging.

Methods
Here, we optimize an orthotopic mouse model of PDAC by altering several conditions, including the subcloning of parental murine PDAC cells, implantation site, number of transplanted cells, and age of recipient mice. We perform spatial profiling to compare primary and metastatic immune microenvironments and RNA sequencing to gain insight into the mechanisms of muscle wasting in PDAC-induced cachexia, comparing non-metastatic to metastatic conditions.

Results
These modifications extend the time course of the disease and concurrently increase the rate of metastasis to approximately 70%. Furthermore, reliable cachexia endpoints are achieved in both PDAC mice with and without metastases, which is reminiscent of patients. We also find that cachectic muscles from PDAC mice with metastasis exhibit a similar transcriptional profile to muscles derived from mice and patients without metastasis.

Conclusion
Together, this model is likely to be advantageous in both advancing our understanding of the mechanism of PDAC cachexia, as well as in the evaluation of novel therapeutics.
Erythroferrone and hepcidin levels in children with iron deficiency anemia
Authors: Dulkadir Ramazan , Turna Saltoğlu Gamze , Güneş Ali 
Published: April 2024

Abstract
Background
Iron deficiency anemia remains a significant public health issue in developing countries. The regulation of iron metabolism is primarily controlled by hepcidin, a key regulatory protein. During erythropoiesis, erythroferrone (ERFE), a hormone produced by erythroblasts in response to erythropoietin (EPO) synthesis, mediates the suppression of hepcidin. In this study, it was aimed to determine the correlation between erythroferrone (ERFE) and hepcidin levels in children with iron deficiency anemia.

Methods
This is a case-control study conducted at Kırşehir Ahi Evran University Training and Research Hospital Pediatrics Clinic between 1 and 31 September 2020. The study included 26 healthy children and 26 children with iron deficiency anemia. In order to evaluate iron status,whole blood count, serum iron, total iron binding capacity (TIBC), and ferritin levels were analyzed. The study measured the levels of hepcidin and erythroferrone in the serum of children diagnosed with iron deficiency before and after one month of iron treatment, as well as in a control group, using the ELISA method. Correlation between whole blood count, initial ferritin, hepcidin, ERFE and ferritin in the iron deficiency group was evaluated.

Results
Compared with healthy controls, the iron-deficient group had significantly lower haemoglobin (p < 0.001), MCV (p = 0.001), MCH (p < 0.001), MCHC (p < 0.001), iron (p < 0.001), ferritin (p < 0.001) and hepcidin (p = 0.001). Ferritin and hepcidin levels increased while erythroferrone levels remained unchanged after iron deficiency treatment. There was no correlation between hepcidin and ferritin levels in treatment group.

Conclusions
The study found a strong and positive correlation between ferritin and hepcidin levels in iron-deficient children, but not between ERFE levels, suggesting that hepcidin is largely regulated by iron deposition levels. In addition, there was an increase in ferritin and hepcidin levels after iron treatment. The study found no significant difference in erythroferrone levels between the iron-deficient group and the control group. It is thought that this may be due to the short duration of iron treatment given to the patients with iron deficiency anemia included in the study.
Effectiveness and cost-effectiveness of community-based mental health services for individuals with severe mental illness in Iran: a systematic review and meta-analysis
Authors: Taban Mozhgan , Nooraeen Sara , Tanha Kiarash , Moradi-Lakeh Maziar , Malakouti Seyed Kazem 
Published: April 2024

Abstract
Background
Severe mental illness (SMI) imposes a substantial worldwide burden of disability, highlighting the need for comprehensive and adaptable mental health services. This study aims to assess the efficacy and cost-effectiveness of community-based mental health services (CBMHS) in reducing relapse and rehospitalization rates among individuals with SMI in Iran.

Method
A systematic review and meta-analysis were conducted. Medline, EMBASE, ISI, SCOPUS, and ProQuest were searched until December 2022. We focused on randomized controlled trials, quasi-experimental studies, or economic studies related to individuals with SMI. Out of 127 articles, 17 were selected for a full-text review. The primary outcomes were the severity of psychopathology, rehospitalization rates, and the mental health of caregivers. We also examined community-based interventions and their impact on various outcomes. Data extraction and risk of bias assessment were performed, and critical appraisal was conducted using JBI checklists. Meta-analysis was carried out using STATA software. (PROSPERO registration. CRD42022332660).

Result
Rehospitalization rates among patients who received CBMHS were significantly lower, with an odds ratio of 2.14 (95% CI: 1.44 to 3.19), indicating a 2.14 times lower likelihood than those who received treatment as usual. A reduction in psychopathology accompanied this, SMD: -0.31, 95% CI: -0.49 to -0.13, I2 = 40.23%). Moreover, there was a notable improvement in social skills (SMD: -0.7, 95% CI: -0.98 to -0.44, I2 = 0.00%). The burden on caregivers also decreased (SMD: -0.55, 95% CI: -0.99 to -0.1, I2 = 63.2). The Incremental Cost-Effectiveness Ratio (ICER) for QUALY was acceptable, albeit with a wide range of 613 to 8400 Dollars.

Conclusion
CBMHS has demonstrated effectiveness and efficiency in Iran as a developing country. Additionally, it shows promise in mitigating the shortage of acute psychiatry beds. Using multiple data collection tools poses a limitation regarding data consolidation and conducting a meta-analysis.