bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of mitomycin C in reducing recurrence of epidural fibrosis after repeated operation in a laminectomy model in rats
Authors: Lee Jin-Yul , Stenzel Werner , Löhr Mario , Stützer Hartmut , Ernestus Ralf-Ingo , Klug Norfrid 
Published: January 2008

ObjectExtensive peridural fibrosis after lumbar spine surgery may contribute to poor outcome and recurrent symptoms leading to repeated operation. Secondary procedures are considerably hampered by the presence of scar tissue. Moreover, after excision of the peridural scar, the fibrous tissue may recur, leading to unsuccessful surgical outcome. Mitomycin C (MMC), an alkylating antibiotic substance isolated fromStreptomyces caespitosus, potentially suppresses fibroblast proliferation after surgical intervention. The authors investigated the effect of MMC on the reformation of epidural fibrosis in a laminectomy model in rats.MethodsTwenty-four Wistar rats underwent a repeated lumbar laminectomy 3 months after the first operation. In 12 rats, MMC in a concentration of 1 mg/ml was locally applied to the laminectomy site. No treatment was performed in the control group of the other 12 rats. All rats underwent clinical evaluation. Mobility ratings and any evidence of neurological deficit were recorded. Twelve weeks after the second operation, the animals were killed for histological examination. The extent of epidural fibrosis and dural adherence was evaluated.All MMC-treated animals showed reduced epidural scarring, compared with the control group. In nine MMC-treated rats (75%), dural adhesions were moderate. In contrast, all control sites showed dense epidural fibrosis with marked dural adherence. No side effects of the treatment were observed.ConclusionsIn this experimental study, MMC in a concentration of 1 mg/ml locally applied significantly reduced recurrence of epidural fibrosis and dural adhesions without any side effects after repeated spinal surgery in a laminectomy model in rats.
Aggressive postoperative lumbar fibromatosis after the placement of instrumentation for treatment of spondylolisthesis
Authors: Güzey Feyza Karagöz , Emel Erhan , Bas N. Serdar , Ozkan Nezih , Turgut Hurriyet , Sel Baris 
Published: January 2008

✓ This 50-year-old woman presented with a paravertebral lumbar fibromatosis (desmoid tumor) after undergoing the placement of instrumentation for lumbar spondylolisthesis. The tumor developed just cranial to the previous skin incision. Fibromatoses, or desmoid tumors, are uncommon infiltrative lesions that affect musculoaponeurotic structures, most often of the trunk and limbs. They are known to occur in association with surgery-related scars or implants and only rare examples appear in the neurosurgical and spine-related literature. In cases involving well-defined tumors in which radical resection is possible, surgery is the treatment of choice; however, the recurrence rate is high. The patient in the present case was followed for 14 months postoperatively and did not undergo radiotherapy; there was no recurrence.
Although rare, this distinctive tumor should be considered in the differential diagnosis of postoperative paravertebral bulgings after neurosurgical and spinal operations.
Cervical radiofrequency neurotomy in patients with chronic whiplash: a study of multiple outcome measures
Authors: Prushansky Tamara , Pevzner Evgeny , Gordon Carlos , Dvir Zeevi 
Published: January 2008

Object
Cervical radiofrequency neurotomy (CRFN) is used in the treatment of patients with chronic pain and disability due to whiplash injury. Confirmation of its efficiency has, however, been based solely on pain and psychological distress factors. The aim of the present study was to extend the assessment of CRFN efficacy by adding other outcome measures to shed light on neuromotor-functional-psychological interactions by undertaking comparison of pre- and 1-year postintervention data.

Methods
Forty patients with chronic whiplash injury–associated disorders were evaluated prior to and at two separate sessions after CRFN. The evaluation included Neck Disability Index, cervical range of motion, isometric cervical muscle strength, cervical pressure pain threshold, Symptom Check List–90-Revised, and subjective Self-Report of Improvement (SRI). The authors found that the CRFN had a significantly positive effect on all measured parameters. A case-by-case analysis revealed improvement in 70% of the patients at the final follow-up examination. Using stringent cutoff values, between 30 and 60% of the patients experienced measurable improvement. Evaluation of SRI results indicated that more than 80% of the patients were satisfied with the procedure.

Conclusions
Approximately 1 year after intervention, CRFN was associated with an acceptable rate of success, as reflected by objective and subjective outcome measures.
Head-turned rear impact causing dynamic cervical intervertebral foramen narrowing: implications for ganglion and nerve root injury
Authors: Tominaga Yasuhiro , Maak Travis G. , Ivancic Paul C. , Panjabi Manohar M. , Cunningham Bryan W. 
Published: January 2008

Object
A rotated head posture at the time of vehicular rear impact has been correlated with a higher incidence and greater severity of chronic radicular symptoms than accidents occurring with the occupant facing forward. No studies have been conducted to quantify the dynamic changes in foramen dimensions during head-turned rear-impact collisions. The objectives of this study were to quantify the changes in foraminal width, height, and area during head-turned rear-impact collisions and to determine if dynamic narrowing causes potential cervical nerve root or ganglion impingement.

Methods
The authors subjected a whole cervical spine model with muscle force replication and a surrogate head to simulated head-turned rear impacts of 3.5, 5, 6.5, and 8 G following a noninjurious 2-G baseline acceleration. Continuous dynamic foraminal width, height, and area narrowing were recorded, and peaks were determined during each impact; these data were then statistically compared with those obtained at baseline.
The authors observed significant increases (p < 0.05) in mean peak foraminal width narrowing values greater than baseline values, of up to 1.8 mm in the left C5–6 foramen at 8 G. At the right C2–3 foramen, the mean peak dynamic foraminal height was significantly narrower than baseline when subjected to rear-impacts of 5 and 6.5 G, but no significant increases in foraminal area were observed. Analysis of the results indicated that the greatest potential for cervical ganglion compression injury existed at C5–6 and C6–7. Greater potential for ganglion compression injury existed at C3–4 and C4–5 during head-turned rear impact than during head-forward rear impact.

Conclusions
Extrapolation of present results indicated potential ganglion compression in patients with a non-stenotic foramen at C5–6 and C6–7; in patients with a stenotic foramen the injury risk greatly increases and spreads to include the C3–4 through C6–7 as well as C4–5 through C6–7 nerve roots.
Nonmissile penetrating spinal injury
Authors: Shahlaie Kiarash , Chang Dongwoo John , Anderson John T. 
Published: January 2008

✓ Nonmissile penetrating spinal injuries (NMPSIs) are rare, even among the population of patients treated in large trauma centers. Patients who present with retained foreign body fragments due to stabbings represent an even smaller subset of NMPSI, and their optimal management is unclear.The authors report the case of a 42-year-old man who presented to the University of California at Davis Medical Center with a retained knife blade after suffering a stab wound to the lower thoracic spine. They discuss this case in the context of a literature review and propose management options for patients with NMPSIs in whom fragments are retained.A search of PubMed was undertaken for articles published between 1950 and 2006; the authors found 21 case reports and eight case series in the English-language literature but discovered no published guidelines on the management of cases of NMPSI with retained fragments.After clinicians undertake appropriate initial trauma evaluation and resuscitation, they should obtain plain x-ray films and computerized tomography scans to delineate the anatomical details of the retained foreign body in relation to the stab wound. Neurosurgical consultation should be undertaken in all patients with an NMPSI, whether or not foreign body fragments are present. Surgical removal of a retained foreign body is generally recommended in these patients because the fragments may lead to a worse neurological outcome. Perioperative antibiotic therapy may be beneficial, but the result depends on the nature of the penetrating agent. There is no documentation in the literature to support the use of steroid agents in patients with NMPSIs.
Pedicle subtraction osteotomy in the treatment of chronic, posttraumatic kyphotic deformity
Authors: Heary Robert F. , Bono Christopher M. 
Published: January 2008

Object
Thoracolumbar fractures, treated operatively or nonoperatively, may cause painful kyphotic deformities over time. A pedicle subtraction osteotomy (PSO) is a single-stage posterior procedure designed to correct sagittal plane deformity. Although it was initially used to treat nontraumatic conditions, a PSO can be highly effective in chronic, posttraumatic fractures of the lumbar spine. In this report the authors review details obtained in the treatment of three patients with severe, posttraumatic spinal deformities. They describe the surgical technique used to correct the sagittal malalignments.

Methods
All three patients were middle aged, and good bone mineral density had been demonstrated in each case preoperatively. After PSO, a mean 51° improvement in sagittal alignment was achieved and maintained until a solid arthrodesis was documented in each case. Substantial improvements in pain relief and functional outcome were observed. A detailed, procedure-specific literature review was undertaken.

Conclusions
A PSO is a valuable tool to add to the armamentarium of neurosurgeons who treat patients suffering from painful posttraumatic deformity following fractures of the upper lumbar spine.
The effect of mitomycin C in reducing epidural fibrosis after lumbar laminectomy in rats
Authors: Lee Jin-Yul , Stenzel Werner , Impekoven Peter , Theisohn Martin , Stützer Hartmut , Löhr Mario , Reithmeier Thomas , Ernestus Ralf-Ingo , Ebel Heinrich , Klug Norfrid 
Published: January 2008

Object
xtensive epidural fibrosis after lumbar spine surgery might be an important underlying cause of failed-back syndrome. Based on previously obtained data, the effect of mitomycin C (MMC) in a concentration of 0.1 mg/ml on spinal epidural fibrosis in a rat laminectomy model was investigated in a large series.

Methods
ighty adult Wistar rats underwent lumbar laminectomy. In 40 rats, MMC in a concentration of 0.1 mg/ml was locally applied to the laminectomy sites. No similar treatment was performed in the other 40 rats. At intervals from one to 12 weeks after laminectomy, both macroscopic and histological evaluations were performed. For radiological investigation, 10 rats underwent magnetic resonance (MR) imaging at 6 weeks postoperatively. Furthermore, the concentration of MMC in cerebrospinal fluid (CSF) and serum was determined 12 hours postoperatively in seven rats.
Due to ease of absorption, high levels of MMC were rapidly detectable in serum, whereas the values obtained from the CSF were markedly lower. In the majority of MMC-treated laminectomy sites, epidural scarring was significantly reduced and dural adhesions were absent, in comparison with control sites (p < 0.001), as confirmed by MR images. Accordingly, the macroscopic dissection of epidural fibrous tissue to reexpose the dura mater was performed more easily and without severe bleeding in these rats. The healing of skin and the lumbar fascia was not affected, and dural leakage was not observed. All control sites showed dense epidural fibrosis with marked dural adherence.

Conclusions
n this experimental model, it was shown that locally applied MMC in a concentration of 0.1 mg/ml effectively reduces epidural fibrosis and dural adherence without side effects in rats that underwent lumbar laminectomy.
A review of factors predictive of surgical outcome for ossification of the ligamentum flavum of the thoracic spine
Authors: Inamasu Joji , Guiot Bernard H. 
Published: January 2008

Object
Ossification of the ligamentum flavum (OLF) is a pathological condition that affects the ligament and causes slowly progressive myeloradiculopathy in adults. Although OLF has been regarded as endemic to East Asian countries, studies from outside these areas have increasingly been reported. Because of long-standing compression of the spinal cord by OLF, a patient’s functional prognosis may not always be favorable, and attempts have been made in recent studies to identify clinical factors that are predictive of the surgical outcome of patients with thoracic OLF.

Methods
The authors conducted a review of the literature published in the English, Japanese, and Korean languages. They examined studies in which correlation between clinical factors and outcome was statistically evaluated. The clinical factors included sex, age, level of the ossified ligamentum flavum, number of segments affected by OLF, coexisting ossification of the posterior longitudinal ligament (OPLL) or other spinal disorders, preoperative duration of symptoms, preoperative neurological score, computed tomography (CT)–based classification, and the presence of intramedullary high signal intensity on T2-weighted magnetic resonance images.

Conclusions
The clinical factors that are unlikely to be predictive of outcome include sex, age, level of the ossified lesion, number of OLF-affected segments, coexisting OPLL, CT classification, and the presence of high signal intensity. It is unclear whether the preoperative duration of symptoms or neurological score is predictive of outcome because the results have been inconsistent among the studies. Analysis of the more recent literature, however, suggests that these two factors are predictive of outcome. The use of a neurological score should be standardized so that compilation and comparison of data can be facilitated.
Revision surgery of the lumbar spine: anterior lumbar interbody fusion followed by percutaneous pedicle screw fixation
Authors: Lee Sang-Ho , Kang Byung-Uk , Jeon Sang Hyeop , Park Jong Dae , Maeng Dae Hyeon , Choi Young-Geun , Choi Won-Chul 
Published: January 2008

Object
The aim of this study was to evaluate the efficacy of anterior lumbar interbody fusion (ALIF) augmented by percutaneous pedicle screw fixation (PSF) for revision surgery in the lumbar spine and to determine the prognostic factors affecting surgical outcomes.

Methods
The population included 54 consecutively treated patients in whom revision surgery involving ALIF with PSF was performed between 2001 and 2004. There were 22 men and 32 women, whose mean age was 59.5 years (range 25–78 years). The diagnoses prior to revision ALIF were as follows: degenerative disc disease in 25 patients, instability/spondylolisthesis in 15, recurrent disc herniation in seven, and pseudarthrosis in seven. The mean follow-up period was 24 months (range 12–52 months). The mean visual analog scale score for back and leg pain decreased, respectively, from 7.8 to 2.3 and 8.0 to 2.3 (p < 0.001). The mean Oswestry Disability Index score improved from 70 to 25% (p < 0.001). Radiological evidence of fusion was noted in 52 of 54 patients. The mean preoperative segmental lordosis, whole lumbar lordosis, and sacral tilt were 15.2, 35.5, and 28.3°, respectively; these values were significantly increased to 20.4, 40.7, and 31.4°, respectively, after revision surgery (p < 0.001). The increase in sacral tilt was positively correlated with improvement in back pain (p = 0.028) and functional status (p = 0.025).

Conclusions
The results demonstrate that ALIF followed by PSF can be an effective alternative in revision surgery of the lumbosacral spine in selected cases. Not only can solid fusion be achieved, sagittal alignment can also be restored in the majority of patients.
Delayed postoperative spinal epidural hematoma causing tetraplegia
Authors: Neo Masashi , Sakamoto Takeshi , Fujibayashi Shunsuke , Nakamura Takashi 
Published: January 2008

✓The authors describe a case of postoperative spinal epidural hematoma (PSEH) that developed in a patient 9 days after he underwent laminoplasty. A PSEH is a rare but critical complication of spinal surgery that usually occurs within a few days of the procedure. The authors draw attention to the possibility of delayed PSEH and its triggering mechanism. In this case, a 59-year-old man with no history of bleeding disorder underwent cervical laminoplasty for mild myelopathy. On the 7th postoperative day computed tomography demonstrated no abnormal findings in the operative field. On the 9th postoperative day, while straining to defecate, the patient suddenly felt neck and shoulder pain, and tetraplegia rapidly developed. Magnetic resonance imaging demonstrated a huge epidural hematoma. The clot was evacuated during emergency revision surgery, during which the arterial bleeding from a split muscle wall was confirmed. The postoperative course after the revision surgery was uneventful and the patient had none of the previous symptoms 1 year later.
A PSEH causing paralysis can occur even more than a week after surgery. The possibility of a delayed-onset PSEH should be kept in mind, and prompt diagnosis should be made when a patient presents with paresis or paralysis after an operation. The authors recommend advising patients that for a while after surgery they avoid strenuous activity.
Clinical follow up after instrumentation-augmented lumbar spinal surgery in patients with unsatisfactory outcomes
Authors: Hsu Chien-Jen , Chou Wen-Ying , Chang Wei-Ning , Wong Chi-Yin 
Published: January 2008

Object.
The authors investigated the causes of unsatisfactory outcomes in patients who had undergone instrumentation-assisted lumbar surgery and followed the clinical and imaging results of the revision surgery.

Methods.
Myelography and postmyelography computed tomography (CT) scanning were successfully conducted in 103 patients. In nearly 80% of these patients, the main symptom was back pain, with or without leg pain. Additional electromyography and nerve conduction velocity studies were also conducted in 22 patients in whom CT myelography could not help to establish the definitive cause of surgical failure. There were 26 cases of spinal stenosis, 13 of adjacent-segment instability, 15 of pseudarthrosis, 11 of screw misplacement, four of epidural fibrosis, five of arachnoiditis, seven of disc disruption, and 22 miscellaneous. When conservative treatment failed to relieve symptoms, surgery was suggested whenever an operable lesion was found. Revision surgery was performed in 48 patients, and these cases form the basis of this retrospective cohort study. All patients underwent clinical and imaging follow up for a minimum of 2 years. Two-year clinical outcomes were assessed using the 36-Item Short Form Health Survey questionnaire and compared with earlier scores using the Student t-test. Fusion status was evaluated by two orthopedic surgeons, who examined flexion–extension x-ray films or CT studies.
The greatest improvement after revision surgery was documented in patients with symptoms related to spinal stenosis or disc disruption. Little improvement was observed in patients with misplaced pedicle screws causing nerve injury and those with epidural fibrosis or arachnoiditis.

Conclusions.
Adequate decompression at the initial operation and prevention of restenosis or accelerated adjacent-segment degeneration yielded the most favorable prognosis in the present cases. Successful posterolateral arthrodesis combined with supplemental interbody fusion improved the surgical outcomes in cases involving disc disruption or degeneration.
Technical description, phantom accuracy, and clinical feasibility for fiducial-free frameless real-time image-guided spinal radiosurgery
Authors: Muacevic Alexander , Staehler Michael , Drexler Christian , Wowra Berndt , Reiser Maximilian , Tonn Joerg-Christian 
Published: January 2008

Object
The authors describe the technical application of the Xsight Spine Tracking System, data pertaining to accuracy obtained during phantom testing, and the initial clinical feasibility of using this fiducial-free alignment system with the CyberKnife in spinal radiosurgery.

Methods
The Xsight integrates with the CyberKnife radiosurgery system to eliminate the need for implantation of radiographic markers or fiducials prior to spinal radiosurgery. It locates and tracks spinal lesions relative to spinal osseous landmarks. The authors performed 10 end-to-end tests of accuracy using an anthropomorphic head and cervical spine phantom. Xsight was also used in the treatment of 50 spinal lesions in 42 patients. Dose planning was based on 1.5-mm-thick computed tomography slices in which an inverse treatment planning technique was used.
All lesions could be treated using the fiducial-free tracking procedure. Phantom tests produced an overall mean targeting error of 0.52 ± 0.22 mm. The setup time for patient alignment averaged 6 minutes (range 2–45 minutes). The treatment doses varied from 12 to 25 Gy to the median prescription isodose of 65% (40 to 70%). The tumor volume ranged between 1.3 and 152.8 cm3The mean spinal cord volume receiving greater than 8 Gy was 0.69 ± 0.35 cm3No short-term adverse events were noted during the 1- to 7-month follow-up period. Axial and radicular pain was relieved in 14 of 15 patients treated for pain.

Conclusions
Fiducial-free tracking is a feasible, accurate, and reliable tool for radiosurgery of the entire spine. By eliminating the need for fiducial implantation, the Xsight system offers patients noninvasive radiosurgical intervention for intra- and paraspinal tumors.
Tapered cages in anterior lumbar interbody fusion: biomechanics of segmental reactions
Authors: Moore Jason , Yoganandan Narayan , Pintar Frank A. , Lifshutz Jason , Maiman Dennis J. 
Published: January 2008

Object
The aim of this study was to determine the in vitro biomechanical responses of lumbar spinal segments after implantation of tapered cages.

Methods
Range of motion (ROM)– and stiffness-related data were determined in 10 human cadaveric T12–S1 columns subjected to flexion, extension, and lateral bending modes before and after anterior lumbar interbody fusion in which stand-alone LT-CAGE devices were used. The overall column showed no significant changes in ROM or stiffness. At the instrumented level, stiffness increased significantly (p < 0.05) in flexion and lateral bending modes. Indications of instability in extension were present, but these values were not statistically significant. There was no evidence of adjacent-level instability at any level in any mode, except for the segment superior to the fixation level in flexion; here there was a significant increase in ROM (p < 0.05) and a decrease in stiffness.

Conclusions
The anatomical conformity and bilateral placement of cages provide ample stability and rigidity at the treated level, comparable to that of other cage systems. Because hypermobility is traditionally related to early degenerative changes, the present results appear to suggest that cages do not significantly contribute to such alterations.