bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multivariate predictors of social skills performance in middle-aged and older out-patients with schizophrenia spectrum disorders
Authors: Sitzer D. I. , Twamley E. W. , Patterson T. L. , Jeste D. V. 
Published: September 2007

BackgroundCognitive impairment and negative symptoms are two of the primary features of schizophrenia associated with poor social functioning. We examined the relationships between clinical characteristics, specific cognitive abilities and social skills performance in middle-aged and older out-patients with schizophrenia and normal comparison subjects.MethodOne hundred and ninety-four middle-aged and older schizophrenia out-patients and 60 normal comparison subjects were administered a standardized, performance-based measure of social skills using role-plays of various social situations [Social Skills Performance Assessment (SSPA)] and measures of current level of social contact (the Lehman Quality of Life Interview), psychiatric symptom severity [the Positive and Negative Syndrome Scale (PANSS) and the Hamilton Depression Rating Scale (HAMD)], insight [the Birchwood Insight Scale (IS)] and cognitive functioning [the Mattis Dementia Rating Scale (DRS)].ResultsPatients demonstrated worse social skills compared with normal subjects. Better performance on the SSPA was associated with having less severe positive and negative symptoms, fewer social contacts, and better attention, initiation/freedom from perseveration, visuospatial ability, abstraction ability and memory. After controlling for demographic, clinical and insight-related factors, abstraction ability was the strongest predictor of social skills performance, followed by frequency of social contact.ConclusionsSocial functioning (as measured through direct observation of social skills performance) was related to cognitive ability in out-patients with schizophrenia. Addressing such cognitive impairment may help to improve social functioning and result in greater overall quality of life.
Conduct disorder among Asians and Native Hawaiian/Pacific Islanders in the USA
Authors: Sakai J. T. , Risk N. K. , Tanaka C. A. , Price R. K. 
Published: September 2007

BackgroundConduct disorder (CD) is a relatively common disorder of childhood and adolescence in the USA with substantial associated morbidity, yet little has been published on CD among Asians and Native Hawaiian/Pacific Islanders (NH/PI) in the USA.MethodWe used the National Epidemiological Survey on Alcohol and Related Conditions (NESARC) to examine the prevalence and correlates of retrospectively reported CD within Asians and NH/PI (18 years and older). We also completed logistic regressions to explore factors associated with CD within Asians (n=1093) and, separately, NH/PI (n=139) and to explain racial differences in CD prevalence.ResultsAsians were about a third as likely [odds ratio (OR) 0.4, 95% confidence interval (CI) 0.22–0.58] whereas NH/PI were about two and half times more likely (OR 2.6, 95% CI 1.31–5.06) to have had CD compared with Caucasian respondents. Within Asians and NH/PI, CD was strongly associated with adult antisocial behavior, substance use and affective disorders. Demographic factors, the age that subjects came to the USA, measures of family environment and family history could not explain the observed differences in prevalence of CD for NH/PI relative to Caucasians.ConclusionsAsian and NH/PI youth with CD represent a subgroup of Asian youth at very high risk for a number of serious psychiatric disorders. Further investigation is needed to explain the high CD prevalence among NH/PI.
Post-traumatic stress disorder following disasters: a systematic review
Authors: Neria Y. , Nandi A. , Galea S. 
Published: September 2007

BackgroundDisasters are traumatic events that may result in a wide range of mental and physical health consequences. Post-traumatic stress disorder (PTSD) is probably the most commonly studied post-disaster psychiatric disorder. This review aimed to systematically assess the evidence about PTSD following exposure to disasters.MethodA systematic search was performed. Eligible studies for this review included reports based on the DSM criteria of PTSD symptoms. The time-frame for inclusion of reports in this review is from 1980 (when PTSD was first introduced in DSM-III) and February 2007 when the literature search for this examination was terminated.ResultsWe identified 284 reports of PTSD following disasters published in peer-reviewed journals since 1980. We categorized them according to the following classification: (1) human-made disasters (n=90), (2) technological disasters (n=65), and (3) natural disasters (n=116). Since some studies reported on findings from mixed samples (e.g. survivors of flooding and chemical contamination) we grouped these studies together (n=13).ConclusionsThe body of research conducted after disasters in the past three decades suggests that the burden of PTSD among persons exposed to disasters is substantial. Post-disaster PTSD is associated with a range of correlates including sociodemographic and background factors, event exposure characteristics, social support factors and personality traits. Relatively few studies have employed longitudinal assessments enabling documentation of the course of PTSD. Methodological limitations and future directions for research in this field are discussed.
Impulsive-aggressive behaviours and completed suicide across the life cycle: a predisposition for younger age of suicide
Authors: McGirr A. , Renaud J. , Bureau A. , Seguin M. , Lesage A. , Turecki G. 
Published: September 2007

BackgroundIt is unclear whether the association between impulsive-aggressive behaviours and suicide exists across different ages.MethodVia psychological autopsy, we examined a total of 645 subjects aged 11–87 years who died by suicide. Proxy-based interviews were conducted using the SCID-I & SCID-II or K-SADS interviews and a series of behavioural and personality-trait assessments. Secondarily, 246 living controls were similarly assessed.ResultsHigher levels of impulsivity, lifetime history of aggression, and novelty seeking were associated with younger age of death by suicide, while increasing levels of harm avoidance were associated with increasing age of suicide. This effect was observed after accounting for age-related psychopathology (current and lifetime depressive disorders, lifetime anxiety disorders, current and lifetime substance abuse disorders, psychotic disorders and cluster B personality disorders). Age effects were not due to the characteristics of informants, and such effects were not observed among living controls. When directly controlling for major psychopathology, the interaction between age, levels of impulsivity, aggression and novelty seeking predicted suicide status while controlling for the independent contributions of age and these traits.ConclusionsHigher levels of impulsive-aggressive traits play a greater role in suicide occurring among younger individuals, with decreasing importance with increasing age.
A pasting lemma and some applications for conservative systems
Authors: ARBIETO ALEXANDER , MATHEUS CARLOS 
Published: September 2007

AbstractWe prove that in a compact manifold of dimension n≥2, C1+α volume-preserving diffeomorphisms that are robustly transitive in the C1-topology have a dominated splitting. Also we prove that for three-dimensional compact manifolds, an isolated robustly transitive invariant set for a divergence-free vector field cannot have a singularity. In particular, we prove that robustly transitive divergence-free vector fields in three-dimensional manifolds are Anosov. For this, we prove a ‘pasting’ lemma, which allows us to make perturbations in conservative systems.
Flattening functions on flowers
Authors: HARRISS EDMUND , JENKINSON OLIVER 
Published: September 2007

AbstractLet T be an orientation-preserving Lipschitz expanding map of the circle ${\mathbb T}$. A pre-image selector is a map $\tau : {\mathbb T} \to {\mathbb T}$ with finitely many discontinuities, each of which is a jump discontinuity, and such that τ(x)∈T−1(x) for all $x\in {\mathbb T}$. The closure of the image of a pre-image selector is called a flower and a flower with p connected components is called a p-flower. We say that a real-valued Lipschitz function can be Lipschitz flattened on a flower whenever it is Lipschitz cohomologous to a constant on that flower. The space of Lipschitz functions which can be flattened on a given p-flower is shown to be of codimension p in the space of all Lipschitz functions, and the linear constraints determining this subspace are derived explicitly. If a Lipschitz function f has a maximizing measure S which is Sturmian (i.e. is carried by a 1-flower), it is shown that f can be Lipschitz flattened on some 1-flower carrying S.
Pattern-equivariant cohomology with integer coefficients
Authors: SADUN LORENZO 
Published: September 2007

AbstractWe relate Kellendonk and Putnam’s pattern-equivariant (PE) cohomology to the inverse-limit structure of a tiling space. This gives a version of PE cohomology with integer coefficients, or with values in any Abelian group. It also provides an easy proof of Kellendonk and Putnam’s original theorem relating PE cohomology to the Čech cohomology of the tiling space. The inverse-limit structure also allows for the construction of a new non-Abelian invariant, the PE representation variety.
Transitional justice: (re)conceptualising the field
Authors: Bell Christine , Campbell Colm , Ní Aoláin Fionnuala 
Published: September 2007

Transitional justice discourse is generally accepted as having its foundations located in the theoretical, policy and practical implications of dealing with past human rights violations in societies that have experienced either repressive politics or violent conflict. Many theorists and policy-makers resolutely assume or defend the notion that ‘dealing with the past’ is where the debates about, and contribution of, the transitional justice paradigm uniquely lie.2Understood in this way, transitional justice as a field of study has grown exponentially, comprising theoretical debates, the comparative assessment of domestic accountability schemes, international criminal justice, the study of truth commissions, and ethical-legal debate concerning the morality of compromise on accountability for gross and systematic violations of human rights.This foreword, building on the previous work of its authors,3extends and expands our contention that transitional justice in this narrow sense must be located in a broader and more problematised understanding of justice in contemporary transitions. We also use the opportunity provided by this symposium to highlight an expansion of conceptual horizons being carried out at the Transitional Justice Institute (University of Ulster), and the innovative approach to the transitional justice field being advanced by a group of diverse inter-disciplinary scholars. The approach advocates both drawing on other disciplines, and firmly supporting parallel disciplinary fields to work alongside a legal research agenda; affirming the importance of rigorous cross-jurisdictional comparisons; and utilising empirical and socio-legal methodology to advance legal inquiry.
Islands and LF-movement in Greek sluicing
Authors:   Merchant
Published: September 2007

AbstractThis paper investigates the interaction of island insensitivities and form-identity effects in sluicing, and examines the consequences of these for the architecture of ellipsis resolution. On the basis of a number of novel facts from Greek, it is argued that current approaches, both PF-deletion and LF-copying, are inadequate. The present data instead motivate a revised LF-copying approach which relies on the scoping movement of indefinites at LF and þ-chain uniformity.
‘Subject’ and EPP in Greek: The discontinuous subject hypothesis
Authors: Philippaki-Warburton Irene , Spyropoulos Vassilios 
Published: September 2007

In the present study we examine the notion ‘subject’ in finite clauses in Greek, a null-subject language, and we investigate the connection between the rich morphological marking of subject-agreement on the verb and the definition of this notion. We propose that ‘subject’ in Greek should be analysed as a discontinuous element which consists of a null nominal element in the SpecTP position satisfying the Extended Projection Principle (EPP), associated with a
pro
at the relevant theta-position inside the VP. We argue that this analysis has not only the theoretical advantage of maintaining the universally strong value of EPP, but also, perhaps more importantly, the descriptive advantage of providing a satisfactory explanation for a number of apparent idiosyncrasies of Greek constructions.
Politeness and formulaicity: Evidence from Cypriot Greek
Authors: Terkourafi Marina 
Published: September 2007

AbstractIn Brown and Levinson’s politeness theory, the degree of indirectness of an utterance is presumed to be commensurate with the sum of the variables of Distance, Power and Ranking of an imposition. This claim was tested with reference to a corpus of spontaneous requests from Cypriot Greek. It emerged that, rather than motivating the choice of a ‘generic’ politeness strategy corresponding to a certain degree of indirectness, particular combinations of values of extra-linguistic variables (such as sex, age and social class of interlocutors, relationship between them, setting) tend to co-occur with particular combinations of the values of linguistic variables (type of verb, subjective modality, number/person). It is proposed that the latter combinations constitute formulae accessed during the production/interpretation of polite discourse in a holistic manner alongside perceivable features of the extra-linguistic context.
Modern Greek dialects: A preliminary classification
Authors: Trudgill Peter 
Published: September 2007

AbstractAlthough there are many works on individual Modern Greek dialects, there are very few overall descriptions, classifications, or cartographical representations of Greek dialects available in the literature. This paper discusses some possible reasons for these lacunae, having to do with dialect methodology, and Greek history and geography. It then moves on to employ the work of Kontossopoulos and Newton in an attempt to arrive at a more detailed classification of Greek dialects than has hitherto been attempted, using a small number of phonological criteria, and to provide a map, based on this classification, of the overall geographical configuration of Greek dialects.
Multiple spaced seeds for homology search
Authors: Ilie Lucian , Ilie Silvana 
Published: September 2007

AbstractMotivation: Homology search finds similar segments between two biological sequences, such as DNA or protein sequences. The introduction of optimal spaced seeds in PatternHunter has increased both the sensitivity and the speed of homology search, and it has been adopted by many alignment programs such as BLAST. With the further improvement provided by multiple spaced seeds in PatternHunterII, Smith–Waterman sensitivity is approached at BLASTn speed. However, computing optimal multiple spaced seeds was proved to be NP-hard and current heuristic algorithms are all very slow (exponential).Results: We give a simple algorithm which computes good multiple seeds in polynomial time. Due to a completely different approach, the difference with respect to the previous methods is dramatic. The multiple spaced seed of PatternHunterII, with 16 weight 11 seeds, was computed in 12 days. It takes us 17 s to find a better one. Our approach changes the way of looking at multiple spaced seeds.Contact: ilie@csd.uwo.ca
Identification of potential HIV-1 targets of minocycline
Authors: Jenwitheesuk Ekachai , Samudrala Ram 
Published: September 2007

AbstractSummary: Minocycline, a broad spectrum antibiotic, has been discovered to have inhibitory activity against HIV-1 in vitro, but the targets inhibited are unknown. We used a docking with dynamics protocol developed by us to predict the binding affinities of minocycline against seven active sites of five HIV-1 proteins to putatively identify the potential target(s) of minocycline. The results indicate that minocycline has the highest predicted binding affinity against HIV-1 integrase.Contact: ram@compbio.washington.edu
Structure-based calculation of drug efficiency indices
Authors: Hetényi Csaba , Maran Uko , García-Sosa Alfonso T. , Karelson Mati 
Published: September 2007

AbstractMotivation: The efficiency indices (EI's) have been derived from the experimental binding affinities of drug candidates to macromolecules. These ‘two-in-one’ measures include information on both pharmacodynamics and pharmacokinetics of the candidate molecules. The time-consuming experimental measurement of binding affinities of extensive molecule libraries may become a bottle-neck of large scale generation and application of EI's.Results: To overcome this limitation, structure-based calculation of new EI's is introduced using the modified free energy function of the popular program package AutoDock. The results are validated on experimental binding data of biochemical systems such as potent inhibitors bound to β-secretase, a key enzyme of Alzheimer's disease and various drug–protein complexes. Application of new EI's is tested. Thermodynamics of EI's and their role in virtual high - throughput screening of drugs and in the development of docking programs are discussed.Contact: csabahete@yahoo.comSupplementary information: Accompanies this manuscript on the publisher's web site.
Phylocomposer and phylodirector: analysis and visualization of transducer indel models
Authors: Holmes Ian 
Published: September 2007

AbstractSummary: Finite-state string transducers are probabilistic tools similar to Hidden Markov Models that can be systematically extended to large number of sequences related by indel and substitution processes on phylogenetic trees. The number of states in such models grows exponentially with the number of nodes in the tree, with the consequence that even quite small trees can be difficult to analyze or visualize. Here, we present two tools, phylocomposer and phylodirector, for working with string transducers. The former tool implements previously described composition algorithms for extending transducers to arbitrary tree topologies, while the latter generates short animations for arbitrary input alignments and phylogenetic trees, illustrating the state path through the composed transducer.Availability: Phylocomposer and phylodirector are freely available at http://biowiki.org/PhyloComposer and http://biowiki.org/PhyloDirectorContact: ihh@berkeley.edu
Assessment of population size and migration routes of silver eel in the River Rhine based on a 2-year combined mark-recapture and telemetry study
Authors: Breteler Jan Klein , Vriese Tim , Borcherding Jost , Breukelaar André , Jörgensen Lothar , Staas Stefan , de Laak Gerard , Ingendahl Detlev 
Published: September 2007

Abstract
Klein Breteler, J., Vriese, T., Borcherding, J., Breukelaar, A., Jörgensen, L., Staas, S., de Laak, G., and Ingendahl, D. 2007. Assessment of population size and migration routes of silver eel in the River Rhine based on a 2-year combined mark-recapture and telemetry study. – ICES Journal of Marine Science, 64: 1450–1456. More than 3000 female silver eels >50 cm were marked and released in the River Rhine at Cologne in 2004 and 2005, and more than 4000 and 6000 per year, respectively, were checked for marks in the different Rhine branches close to the sea. Migration pathways of downstream-migrating eels were also tracked by telemetry from the point of release (300–350 km from the sea, depending on the migration route) through the three main branches of the Rhine (Waal, Nederrijn + Lek, IJssel + Lake IJsselmeer) to the sea. Downstream migration to the sea took from <2 d to more than a year, but was generally in October and November of the year of release. Most successful migrators seemed to find their way to the sea via the Nieuwe Waterweg rather than via Lake IJsselmeer or Haringvliet. Some 23% of released eels of the 2004 cohort and 15% of the 2005 cohort made it to the sea in less than 2 years. The telemetry data suggest that the Nederrijn + Lek watercourse, the only location where hydropower stations have been built in the lower Rhine system, might be important for downstream migration of eels only in the years with greater discharges, suggesting that management measures should concentrate on the Waal and downstream sections to improve spawning escapement of the silver eel population of the Rhine system.
The evolution of helping and harming on graphs: the return of the inclusive fitness effect
Authors: LEHMANN L. , KELLER L. , SUMPTER D. J. T. 
Published: September 2007

AbstractEvolutionary graph theory has been proposed as providing new fundamental rules for the evolution of co‐operation and altruism. But how do these results relate to those of inclusive fitness theory? Here, we carry out a retrospective analysis of the models for the evolution of helping on graphs of Ohtsuki et al. [Nature (2006) 441, 502] and Ohtsuki & Nowak [Proc. R. Soc. Lond. Ser. B Biol. Sci (2006) 273, 2249]. We show that it is possible to translate evolutionary graph theory models into classical kin selection models without disturbing at all the mathematics describing the net effect of selection on helping. Model analysis further demonstrates that costly helping evolves on graphs through limited dispersal and overlapping generations. These two factors are well known to promote relatedness between interacting individuals in spatially structured populations. By allowing more than one individual to live at each node of the graph and by allowing interactions to vary with the distance between nodes, our inclusive fitness model allows us to consider a wider range of biological scenarios leading to the evolution of both helping and harming behaviours on graphs.
The role of selected neuropeptides in pathogenesis of atopic dermatitis
Authors: Salomon J , Baran E 
Published: September 2007

AbstractBackground  Atopic dermatitis (AD) is an inflammatory skin disease of a chronic course. The role of neuropeptides in pathogenesis of this disorder is probably not crucial; however, there is evidence that these substances influence the development and course of AD.Objective  The aim of this study was to evaluate the plasma level of substance P, neuropeptide Y (NPY) and calcitonin gene related peptide (CGRP) in AD patients during exacerbation and remission of the disease.Material and methods  Forty‐nine patients with AD, aged 17 to 56 years, participated in the study. Among this group, there were 25 males (51%) and 24 females (49%). The disease lasted from 1 to 55 years. The severity of the disease was assessed with SCORAD index. The severity of pruritus was evaluated with Visual Analog Scale and a specially designed questionnaire. Neuropeptides plasma level was detected with radioimmunoassay.Results  Substance P plasma level in AD patients during exacerbation and remission was significantly higher than in the control group. There was a negative correlation between substance P plasma level and total IgE level. CGRP plasma level during exacerbation of AD was significantly lower than in healthy controls and increased in the remission. Significantly higher CGRP concentration was observed in patients suffering from severe pruritus; however, both in patients with more and less severe pruritus, CGRP plasma level was lower than in controls. Higher CGRP plasma level was also observed in patients with more severe disease. NPY plasma level in patients with AD was significantly increased both during exacerbation and remission. During remission of AD, NPY concentration was higher than during exacerbation.