bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Analysis of Statewide Reports on Missing and Murdered Indigenous Peoples in the U.S.: What We Know and Where to Go from Here☆
Authors: Fox Kathleen A. , Stanek Kayleigh A. , Mukosi Leonard , Sharp Christopher , Imus‐Nahsonhoya Valaura 
Published: March 2024

AbstractFor generations, Indigenous communities have been calling attention to a widespread form of victimization known as Missing and Murdered Indigenous Peoples (MMIP). In response to grassroots efforts across rural communities, there has been a marked increase in legislation at the federal and state levels to address MMIP from 2018 to the present. Federal legislation has provided the most comprehensive and coordinated model of response to MMIP. This study analyzes how the scope and themes of federal legislation addressing MMIP are mirrored in the bills recently enacted by 14 states addressing MMIP. One goal of this study is to identify strengths and limitations within state legislation and provide insight into critical areas of focus for improving state legislative responses to MMIP. Next, we analyze reports from federal MMIP legislation and the 10 states (among the 14 with legislation) that have currently published MMIP reports to date. Our analysis of MMIP reports expands knowledge on (1) how data were collected and interpreted across jurisdictions, and (2) whether states experience MMIP in similar or different ways. Drawing on our comparative analysis of legislation and reports across jurisdictions, we offer data‐driven recommendations for states to consider when addressing MMIP.
Spontaneous cecal perforation in a cat diagnosed with ultrasonography
Authors: Besson Julie , Brissot Hervé , Azoulay Florian , Benzimra Paul , Fritz Julien 
Published: March 2024

AbstractAn 8‐year‐old cat was presented for an acute history of anorexia, marked abdominal pain, and hyperthermia. Ultrasonography showed a cecal perforation with focal steatitis and adjacent free gas bubbles, consistent with focal peritonitis. Surgery confirmed the imaging findings. An enterectomy was performed with the removal of the cecum and ileocolic valve, and anastomosis between the ileum and colon was performed. Histology revealed transmural enteritis and chronic severe pyogranulomatous peritonitis with intralesional plant fragments.
Utilizing multiscale engineered biomaterials to examine TGF‐β‐mediated myofibroblastic differentiation
Authors: Simpson Aryssa , Krissanaprasit Abhichart , Chester Daniel , Koehler Cynthia , LaBean Thomas H. , Brown Ashley C. 
Published: March 2024

AbstractCells integrate many mechanical and chemical cues to drive cell signalling responses. Because of the complex nature and interdependency of alterations in extracellular matrix (ECM) composition, ligand density, mechanics, and cellular responses it is difficult to tease out individual and combinatorial contributions of these various factors in driving cell behavior in homeostasis and disease. Tuning of material viscous and elastic properties, and ligand densities, in combinatorial fashions would enhance our understanding of how cells process complex signals. For example, it is known that increased ECM mechanics and transforming growth factor beta (TGF‐β) receptor (TGF‐β‐R) spacing/clustering independently drive TGF‐β signalling and associated myofibroblastic differentiation. However, it remains unknown how these inputs orthogonally contribute to cellular outcomes. Here, we describe the development of a novel material platform that combines microgel thin films with controllable viscoelastic properties and DNA origami to probe how viscoelastic properties and nanoscale spacing of TGF‐β‐Rs contribute to TGF‐β signalling and myofibroblastic differentiation. We found that highly viscous materials with non‐fixed TGF‐β‐R spacing promoted increased TGF‐β signalling and myofibroblastic differentiation. This is likely due to the ability of cells to better cluster receptors on these surfaces. These results provide insight into the contribution of substrate properties and receptor localisation on downstream signalling. Future studies allow for exploration into other receptor‐mediated processes.
Incommensurable lattices in Baumslag–Solitar complexes
Authors: Forester Max 
Published: March 2024

AbstractThis paper concerns locally finite 2‐complexes that are combinatorial models for the Baumslag–Solitar groups . We show that, in many cases, the locally compact group contains incommensurable uniform lattices. The lattices we construct also admit isomorphic Cayley graphs and are finitely presented, torsion‐free, and coherent.
Holomorphicity of totally geodesic Kobayashi isometry between bounded symmetric domains
Authors: Kim Sung‐Yeon , Seo Aeryeong 
Published: March 2024

AbstractIn this paper, we study the holomorphicity of totally geodesic Kobayashi isometric embeddings between bounded symmetric domains. First, we show that for a ‐smooth totally geodesic Kobayashi isometric embedding where , are bounded symmetric domains, if is irreducible and or more generally, for any tangent vector of , then is either holomorphic or anti‐holomorphic. Second, we characterize Kobayashi isometries from a reducible bounded symmetric domain to itself.
Hyperaemia during dynamic handgrip exercise is preserved in healthy young subjects after recovery from COVID‐19
Authors: Prodel Eliza , Souza Roberto , Divino Beatriz , Rocha Helena N. M. , Rocha Natalia G. , Nobrega Antonio C. L. 
Published: March 2024

AbstractWe sought to investigate possible impaired hyperaemia during dynamic handgrip exercise (HGE) in young healthy individuals who had recovered from COVID‐19. We tested the vascular function in individuals recovered from COVID‐19 using a nitric oxide donor (i.e., sodium nitroprusside; SNP), which could revert a possible impaired endothelial function during HGE. Further, we tested whether individuals who recovered from COVID‐19 would present exaggerated brachial vascular resistance under an adrenergic agonist (i.e., phenylephrine; PHE) stimuli during HGE. Participants were distributed into two groups: healthy controls (Control; men: n = 6, 30 ± 3 years, 26 ± 1 kg/m2; and women: n = 5, 25 ± 1 years, 25 ± 1 kg/m2) and subjects recovered from COVID‐19 (post‐COVID; men: n = 6, 29 ± 3 years, 25 ± 1 kg/m2; and women: n = 10, 32 ± 4 years, 22 ± 1 kg/m2). Participants in the post‐COVID group tested positive (RT‐PCR) 12–14 weeks before the protocol. Heart rate (HR), brachial blood pressure (BP), brachial blood flow (BBF) and vascular conductance (BVC) at rest were not different between groups. The HGE increased HR (Control: Δ9 ± 0.4 bpm; and post‐COVID: Δ11 ± 0.4 bpm) and BP (Control: Δ6 ± 1 mmHg; and post‐COVID: Δ12 ± 0.6 mmHg) in both groups. Likewise, BBF (Control: Δ632 ± 38 ml/min; and post‐COVID: Δ620 ± 27 ml/min) and BVC (Control: Δ6.6 ± 0.4 ml/min/mmHg; and post‐COVID: Δ6.1 ± 0.3 ml/min/mmHg) increased during HGE. SNP did not change HGE‐induced hyperaemia but did decrease BP, which induced a reflex‐related increase in HR. PHE infusion also did not change the HGE‐induced hyperaemia but raised BP and reduced HR. In conclusion, exercise‐induced hyperaemia is preserved in healthy young subjects 12–14 weeks after recovery from COVID‐19 infection.
Mechanisms mediating muscle metaboreflex control of cardiac output during exercise: Impaired regulation in heart failure
Authors: O'Leary Donal S. , Mannozzi Joseph 
Published: March 2024

AbstractThe ability to increase cardiac output during dynamic exercise is paramount for the ability to maintain workload performance. Reflex control of the cardiovascular system during exercise is complex and multifaceted involving multiple feedforward and feedback systems. One major reflex thought to mediate the autonomic adjustments to exercise is termed the muscle metaboreflex and is activated via afferent neurons within active skeletal muscle which respond to the accumulation of interstitial metabolites during exercise when blood flow and O2 delivery are insufficient to meet metabolic demands. This is one of the most powerful cardiovascular reflexes capable of eliciting profound increases in sympathetic nerve activity, arterial blood pressure, central blood volume mobilization, heart rate and cardiac output. This review summarizes the mechanisms meditating muscle metaboreflex‐induced increases in cardiac output. Although much has been learned from studies using anaesthetized and/or decerebrate animals, we focus on studies in conscious animals and humans performing volitional exercise. We discuss the separate and interrelated roles of heart rate, ventricular contractility, ventricular preload and ventricular–vascular coupling as well as the interaction with other cardiovascular reflexes which modify muscle metaboreflex control of cardiac output. We discuss how these mechanisms may be altered in subjects with heart failure with reduced ejection fraction and offer suggestions for future studies.
Numerical Investigation of a Hydrogen–Air Flame for NOx Prediction
Authors: Leparoux J. , Mercier R. , Puggelli S. , Cailler M. , Moureau V. 
Published: March 2024

Abstract
Sustainable aviation fuels are a major candidate to reduce pollutant emissions in future aeronautical engines. Recently, the use of hydrogen as a fuel has gained a high interest partly because its combustion is free from carbon dioxide, a greenhouse gas, and produces few pollutants, mainly nitrogen oxides (NOx). Over the last decades, efforts on numerical methods for combustion simulation in aero-engines have largely been focused on kerosene-air combustion. However, the current transition may have a significant impact on the computational methodologies for combustor design. Hydrogen defines novel modeling issues and challenges the current state of art on numerical methodologies. The current study presents a numerical investigation of a hydrogen–air burner using large-eddy simulations (LES) with a focus on NOx prediction. The considered configuration is a two-staged combustor, similar to the well-known RQL (Rich-Quench-Lean) technology, supplied by a single coaxial injector characterized experimentally. Two combustion models are investigated: (i) tabulated chemistry based on premixed flamelets (ii) transported chemistry description by using a 21-species chemical scheme. Numerical results are compared with experimental data (NOx concentrations, temperature distributions, pressure losses). A focus on model predictions is carried out. Results show a good agreement to predict the main flow characteristics and the premixed flame position over different operating points and geometries for both frameworks. In contrast, NOx emissions are more sensitive: while the overall trend is well captured, the quantification is more scattered. Finally, an in-depth analysis is proposed to link NOx production with the nonpremixed flame size.
Sex-related differential item functioning of the Jenkins Sleep Scale: a cross-sectional study among 77 967 employees in the Finnish public sector
Authors: Juhola Juhani , Arokoski Jari P A , Ervasti Jenni , Kivimäki Mika , Vahtera Jussi , Myllyntausta Saana , Saltychev Mikhail 
Published: March 2024

ObjectivesTo investigate if the Jenkins Sleep Scale (JSS) demonstrates sex-related differential item functioning (DIF).DesignCross-sectional study.SettingSurvey data from the Finnish Public Sector study (2015–2017).Participants77 967 employees in the Finnish public sector, with a mean age of 51.9 (SD 13.1) years and 82% women.Outcome measuresItem response theory estimates: difficulty and discrimination parameters of the JSS and differences in these parameters between men and women.ResultsThe mean JSS total score was 6.4 (4.8) points. For all four items of the JSS, the difficulty parameter demonstrated a slight shift towards underestimation of the severity of sleep difficulties. The discrimination ability of all four items was moderate to high. For the JSS composite score, overall discrimination ability was moderate (0.98, 95% CI 0.97 to 0.99). Mild uniform DIF (p<0.001) was seen: two items showed better discrimination ability among men and two others among women.ConclusionsThe JSS showed overall good psychometric properties among this healthy population of employees in the Finnish public sector. The JSS was able to discriminate people with different severities of sleep disturbances. However, when using the JSS, the respondents might slightly underestimate the severity of these disturbances. While the JSS may produce slightly different results when answered by men and women, these sex-related differences are probably negligible when applied to clinical situations.
Randomised trials conducted using cohorts: a scoping review
Authors: Nickolls Beverley Jane , Relton Clare , Hemkens Lars , Zwarenstein Merrick , Eldridge Sandra , McCall Stephen J , Griffin Xavier Luke , Sohanpal Ratna , Verkooijen Helena M , Maguire Jonathon L , McCord Kimberly A 
Published: March 2024

IntroductionCohort studies generate and collect longitudinal data for a variety of research purposes. Randomised controlled trials (RCTs) increasingly use cohort studies as data infrastructures to help identify and recruit trial participants and assess outcomes.ObjectiveTo examine the extent, range and nature of research using cohorts for RCTs and describe the varied definitions and conceptual boundaries for RCTs using cohorts.DesignScoping review.Data sourcesSearches were undertaken in January 2021 in MEDLINE (Ovid) and EBM Reviews—Cochrane Methodology Registry (Final issue, third Quarter 2012).Eligibility criteriaReports published between January 2007 and December 2021 of (a) cohorts used or planned to be used, to conduct RCTs, or (b) RCTs which use cohorts to recruit participants and/or collect trial outcomes, or (c) methodological studies discussing the use of cohorts for RCTs.Data extraction and synthesisData were extracted on the condition being studied, age group, setting, country/continent, intervention(s) and comparators planned or received, unit of randomisation, timing of randomisation, approach to informed consent, study design and terminology.ResultsA total of 175 full-text articles were assessed for eligibility. We identified 61 protocols, 9 descriptions of stand-alone cohorts intended to be used for future RCTs, 39 RCTs using cohorts and 34 methodological papers.The use and scope of this approach is growing. The thematics of study are far-ranging, including population health, oncology, mental and behavioural disorders, and musculoskeletal conditions.Authors reported that this approach can lead to more efficient recruitment, more representative samples, and lessen disappointment bias and crossovers.ConclusionThis review outlines the development of cohorts to conduct RCTs including the range of use and innovative changes and adaptations. Inconsistencies in the use of terminology and concepts are highlighted. Guidance now needs to be developed to support the design and reporting of RCTs conducted using cohorts.
Effect and safety of electroacupuncture on weight loss in obese patients with pre-diabetes: study protocol of a randomised controlled trial
Authors: Li Xiying , Lin Jingjing , Hu Chenfang , Liu Baojun , Li Feng , Li Jiaying , Zeng Xiaoling , Li Shanshan , Mi Yiqun , Yin Xuan , Xu Shifen 
Published: March 2024

IntroductionObesity has been identified as a significant risk factor for several chronic conditions, including diabetes, tumours and cardiovascular disease, and has been associated with increased mortality rates. Despite the well-established clinical practice of electroacupuncture (EA) as a potential treatment option for obesity, its efficacy remains questionable, primarily due to the paucity of empirical evidence supporting its therapeutic benefits.Methods and analysisThe present study aims to investigate the efficacy and safety of EA for weight loss in obese individuals with pre-diabetes, using a randomised, placebo-controlled clinical trial design. A total of 256 eligible patients will be randomly assigned to one of two groups: EA (comprising EA treatment with health education) or superficial acupuncture (SA) (comprising SA treatment with health education). The intervention will be administered three times per week for the initial 12 weeks, two times per week for the subsequent 8 weeks and one time per week for the final 4 weeks, with a 24-week follow-up period. The primary outcome measure will be the percentage of patients who achieve a reduction of 10% or more in their body weight at week 24. Secondary outcome measures will include changes in body weight and body mass index, blood test results, data collected by the body composition analyser, size of adipose tissue scanned by MRI of the abdomen and the Impact of Weight on Quality of Life, the 21-item Three-Factor Eating Questionnaire-Revised and the Food Craving Questionnaire-Trait. The Treatment Emergent Symptom Scale will be employed to monitor every adverse reaction from baseline to follow-up.Ethics and disseminationThis trial has received ethical clearance from the Ethics Committee of Shanghai Municipal Hospital of Traditional Chinese Medicine under the registration number 2021SHL-KY-74. All participants will provide their written informed consent prior to their enrolment. The findings of this investigation will be disseminated through peer-reviewed publications and scholarly conferences.Trial registration numberNCT05237089.
Students’ perceptions and experiences of an online well-being programme: a phenomenological study protocol
Authors: Escuadra Catherine Joy , Chiong Maya Arlene , Nava Jordan Barbra P , Vergara Jose Avelino , Bea Trisha Coleen , Javier Angelo Miguel , Karamihan Francine , Padilla Diane Pauline , Reyes Albert Josef , Samonte Julia , Serrano Sophia Ivonne 
Published: March 2024

BackgroundThe pandemic has ensued challenges across all sections of the human population such as livelihood and educational changes, which involve the abrupt shift to online learning, immensely affecting the students’ well-being. Negative health consequences of e-learning among students stem from the increased demand for new technological skills, productivity, information overload and restriction of students to spend time with their peers.ObjectiveTo explore the experiences of the students from the University of Santo Tomas—College of Rehabilitation Sciences (UST-CRS) who participated in the online well-being programme.MethodologyA phenomenological design will be used to determine the participants’ perceptions and experiences. Purposive sampling will be used to recruit 8–10 undergraduate students from UST-CRS ages 18–22 years, who participated in the well-being programme, and completed the study’s quantitative counterpart. Semistructured, in-depth questions will be used to conduct a focus group discussion. The transcripts will be analysed using thematic analysis via the NVivo V.12 software.Ethics and disseminationThe study protocol is approved by the UST-CRS Ethical Review Committee (Protocol Number: SI-2022–034 (V.4)). It will be implemented in accordance with the Declaration of Helsinki and the National Ethical Guidelines for Health and Health-Related Research, and Data Privacy Act. Findings will be published in accredited journals and presented in related scientific fora.Registration IDPHRR230214-005419; Philippine Health Research Registry.
Symptomology following COVID-19 among adults in Alberta, Canada: an observational survey study
Authors: Chen Xueyi , Norris Colleen , Whitten Tara , Ho Chester , Mann Balraj , Bakal Jeffrey 
Published: March 2024

ObjectiveFatigue, headache, problems sleeping and numerous other symptoms have been reported to be associated with long COVID. However, many of these symptoms coincide with symptoms reported by the general population, possibly exacerbated by restrictions/precautions experienced during the COVID-19 pandemic. This study examines the symptoms reported by individuals who tested positive for COVID-19 compared with those who tested negative.DesignObservational study.SettingThe study was conducted on adult residents in Alberta, Canada, from October 2021 to February 2023.ParticipantsWe evaluated self-reported symptoms in 7623 adults with positive COVID-19 tests and 1520 adults who tested negative, using surveys adapted from the internationally standardised International Severe Acute Respiratory and emerging Infection Consortium (ISARIC)-developed COVID-19 long-term follow-up tools. These individuals had an index COVID-19 test date between 1 March 2020 and 31 December 2022 and were over 28 days post-COVID-19 testing.Primary outcome measuresThe primary outcomes were to identify the symptoms associated with COVID-19 positivity and risk factors for reporting symptoms.ResultsFatigue was the top reported symptom (42%) among COVID-19-positive respondents, while headache was the top reported symptom (32%) in respondents who tested negative. Compared with those who tested negative, COVID-19-positive individuals reported 1.5 times more symptoms and had higher odds of experiencing 31 out of the 40 listed symptoms during the postinfectious period. These symptoms included olfactory dysfunction, menstruation changes, cardiopulmonary and neurological symptoms. Female sex, middle age (41–55 years), Indigeneity, unemployment, hospital/intensive care unit (ICU) admission at the time of testing and pre-existing health conditions independently predicted a greater number and variety of symptoms.ConclusionsOur results provide evidence that COVID-19 survivors continue to experience a significant number and variety of symptoms. These findings can help inform targeted strategies for the unequally affected population. It is important to offer appropriate management for symptom relief to those who have survived the acute COVID-19 illness.
Engaging people with lived experiences on community advisory boards in community-based participatory research: a scoping review protocol
Authors: Nelson Georgia , Kettaneh Hasan , Knox Bruce , Purkey Eva , Chan-Nguyen Sophy , Jenkins Meghan , Bayoumi Imaan 
Published: March 2024

IntroductionCommunity-based participatory research (CBPR) is a collaborative research approach that equally engages researchers and community stakeholders throughout all steps of the research process to facilitate social change and increase research relevance. Community advisory boards (CABs) are a CBPR tool in which individuals with lived experience and community organisations are integrated into the research process and ensure the work aligns with community priorities. We seek to (1) explore the best practices for the recruitment and engagement of people with lived experiences on CABs and (2) identify the scope of literature on minimising power dynamics between organisations and community members with lived experience who work on CABs together.Methods and analysisThis scoping review will follow the Arksey and O’Malley methodological framework, informed by Levacet al, and will be reported using a PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) diagram. Detailed and robust search strategies have been developed for Embase, Medline and PsychINFO. Grey literature references and reference lists of included articles published between 1 January 1990 and 30 March 2023 will be considered. Two reviewers will independently screen references in two successive stages of title/abstract and full-text screening. Conflicts will be decided by consensus or a third reviewer. Thematic analysis will be applied in three phases: open coding, axial coding and abstraction. Extracted data will be recorded and presented in a tabular format and/or graphical summaries, with a descriptive overview discussing how the research findings relate to the research questions. At this time, a preliminary search of peer-reviewed and grey literature has been conducted. Search results for peer-reviewed literature have been uploaded to Covidence for review and appraisal for relevance.Ethics and disseminationFormal ethics approval is not required for this review. Review findings will inform ongoing and future CBPR community advisory board dynamics.RegistrationThe protocol has been registered prospectively on the Open Science Framework (https://doi.org/10.17605/OSF.IO/QF5D3)