bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of a Changing Southern Hemisphere Annular Mode on Antarctic Peninsula Summer Temperatures
Authors: Marshall Gareth J. , Orr Andrew , van Lipzig Nicole P. M. , King John C. 
Published: October 2006

Abstract
Since the mid-1960s, rapid regional summer warming has occurred on the east coast of the northern Antarctic Peninsula, with near-surface temperatures increasing by more than 2°C. This warming has contributed significantly to the collapse of the northern sections of the Larsen Ice Shelf. Coincident with this warming, the summer Southern Hemisphere Annular Mode (SAM) has exhibited a marked trend, suggested by modeling studies to be predominantly a response to anthropogenic forcing, resulting in increased westerlies across the northern peninsula.
Observations and reanalysis data are utilized to demonstrate that the changing SAM has played a key role in driving this local summer warming. It is proposed that the stronger summer westerly winds reduce the blocking effect of the Antarctic Peninsula and lead to a higher frequency of air masses being advected eastward over the orographic barrier of the northern Antarctic Peninsula. When this occurs, a combination of a climatological temperature gradient across the barrier and the formation of a föhn wind on the lee side typically results in a summer near-surface temperature sensitivity to the SAM that is 3 times greater on the eastern side of the peninsula than on the west. SAM variability is also shown to play a less important role in determining summer temperatures at stations west of the barrier in the northern peninsula (∼62°S), both at the surface and throughout the troposphere. This is in contrast to a station farther south (∼65°S) where the SAM exerts little influence.
Atlantic Climate Variability and Predictability: A CLIVAR Perspective
Authors: Hurrell J. W. , Visbeck M. , Busalacchi A. , Clarke R. A. , Delworth T. L. , Dickson R. R. , Johns W. E. , Koltermann K. P. , Kushnir Y. , Marshall D. , Mauritzen C. , McCartney M. S. , Piola A. , Reason C. , Reverdin G. , Schott F. , Sutton R. , Wainer I. , Wright D. 
Published: October 2006

Abstract
Three interrelated climate phenomena are at the center of the Climate Variability and Predictability (CLIVAR) Atlantic research: tropical Atlantic variability (TAV), the North Atlantic Oscillation (NAO), and the Atlantic meridional overturning circulation (MOC). These phenomena produce a myriad of impacts on society and the environment on seasonal, interannual, and longer time scales through variability manifest as coherent fluctuations in ocean and land temperature, rainfall, and extreme events. Improved understanding of this variability is essential for assessing the likely range of future climate fluctuations and the extent to which they may be predictable, as well as understanding the potential impact of human-induced climate change. CLIVAR is addressing these issues through prioritized and integrated plans for short-term and sustained observations, basin-scale reanalysis, and modeling and theoretical investigations of the coupled Atlantic climate system and its links to remote regions. In this paper, a brief review of the state of understanding of Atlantic climate variability and achievements to date is provided. Considerable discussion is given to future challenges related to building and sustaining observing systems, developing synthesis strategies to support understanding and attribution of observed change, understanding sources of predictability, and developing prediction systems in order to meet the scientific objectives of the CLIVAR Atlantic program.
Do Changes in the Midlatitude Circulation Have Any Impact on the Arctic Surface Air Temperature Trend?
Authors: Graversen R. G. 
Published: October 2006

Abstract
The warming of the near-surface air in the Arctic region has been larger than the global mean surface warming. There is general agreement that the Arctic amplification of the surface air temperature (SAT) trend to a considerable extent is due to local effects such as the retreat of sea ice, especially during the summer months, and earlier melting of snow in the spring season. There is no doubt that these processes are important causes of the Arctic SAT trend. It is less clear, however, whether the trend may also be related to recent changes in the atmospheric midlatitude circulation. This question is the focus of the present paper.
Model experiments have shown that in a warmer climate responding to, for example, a doubling of CO2, the atmospheric northward energy transport (ANET) will increase and cause polar SAT amplification. In the present study, the development of the ANET across 60°N and its linkage to the Arctic SAT have been explored using the ERA-40 reanalysis data from the European Centre for Medium-Range Weather Forecasts (ECMWF). It is found that during 1979–2001, the ANET has experienced an overall positive but weak trend, which was largest during the period from the mid-1980s to the mid-1990s. In addition, it is found that the Arctic SAT is sensitive to variability of the ANET across 60°N and hence to variability of the midlatitude circulation: A large ANET is followed by warming of the Arctic where ANET leads by about 5 days. The warming is located primarily north of the Atlantic and Pacific sectors, indicating that baroclinic weather systems developing around the Icelandic and Aleutian lows are important for the energy transport. Furthermore, it is suggested here that a small, but statistically significant, part of the mean Arctic SAT trend is linked to the trend in the ANET.
Another important indicator of the midlatitude circulation is the Arctic Oscillation (AO). Through the 1980s and early 1990s the AO index has shown a positive trend. However, even though a part of the SAT trend can be related to the AO in localized parts of the Arctic area, the mean Arctic SAT trend shows no significant linkage to the AO.
Analysis of Convection and Its Association with African Easterly Waves
Authors: Mekonnen Ademe , Thorncroft Chris D. , Aiyyer Anantha R. 
Published: October 2006

Abstract
The association between convection and African easterly wave (AEW) activity over tropical Africa and the tropical Atlantic during the boreal summer is examined using satellite brightness temperature (TB) and ECMWF reanalysis datasets. Spectral analysis using 18 yr of TB data shows significant variance in the 2–6-day range across most of the region. Within the regions of deep convection, this time scale accounts for about 25%–35% of the total variance.
The 2–6-day convective variance has similar amplitudes over western and eastern Africa, while dynamic measures of AEW activity show stronger amplitudes in the west. This study suggests that weak AEW activity in the east is consistent with initial wave development there and indicates that convection triggered on the western side of the mountains over central and eastern Africa, near Darfur (western Sudan) and Ethiopia, has a role in initiating AEWs westward. The subsequent development and growth of AEWs in West Africa is associated with stronger coherence with convection there.
Results show large year-to-year variability in convection at the 2–6-day time scale, which tends to vary consistently with the mean convection and dynamical measures of AEW activity over West Africa and the Atlantic, but not over central and eastern Africa. The Darfur region is particularly important for providing convective precursors that propagate westward and trigger AEWs downstream. During wet years, convection over eastern Africa (western Ethiopian highlands) can be a significant source of AEW initiation. In addition to being important for precursors of AEWs, the Darfur region is also a source of convection that propagates eastward toward Ethiopia.
Integration of Weather System Variability to Multidecadal Regional Climate Change: The West African Sudan–Sahel Zone, 1951–98
Authors: Bell Michael A. , Lamb Peter J. 
Published: October 2006

Abstract
Since the late 1960s, the West African Sudan–Sahel zone (10°–18°N) has experienced persistent and often severe drought, which is among the most undisputed and largest regional climate changes in the last half-century. Previous documentation of the drought generally has used monthly, seasonal, and annual rainfall totals and departures, in a standard “climate” approach that overlooks the underlying weather system variability. Most Sudan–Sahel rainfall occurs during June–September and is delivered by westward-propagating, linear-type, mesoscale convective systems [disturbance lines (DLs)] that typically have much longer north–south (102–103 km) than east–west (10–102 km) dimensions. Here, a large set of daily rainfall data is analyzed to relate DL and regional climate variability on intraseasonal-to-multidecadal time scales for 1951–98. Rain gauge–based indices of DL frequency, size, and intensity are evaluated on a daily basis for four 440-km square “catchments” that extend across most of the West African Sudan–Sahel (18°W–4°E) and are then distilled into 1951–98 time series of 10-day and seasonal frequency/magnitude summary statistics. This approach is validated using Tropical Applications of Meteorology Using Satellite Data (TAMSAT) satellite IR cold cloud duration statistics for the same 1995–98 DLs.
Results obtained for all four catchments are remarkably similar on each time scale. Long-term (1951–98) average DL size/organization increases monotonically from early June to late August and then decreases strongly during September. In contrast, average DL intensity maximizes 10–30 days earlier than DL size/organization and is distributed more symmetrically within the rainy season for all catchments except the westernmost, where DL intensity tracks DL size/organization very closely. Intraseasonal and interannual DL variability is documented using sets of very deficient (8) and much more abundant (7) rainy seasons during 1951–98. The predominant mode of rainfall extremes involves near-season-long suppression or enhancement of the seasonal cycles of DL size/organization and intensity, especially during the late July–late August rainy season peak. Other extreme seasons result solely from peak season anomalies. On the multidecadal scale, the dramatic decline in seasonal rainfall totals from the early 1950s to the mid-1980s is shown to result from pronounced downtrends in DL size/organization and intensity. Surprisingly, this DL shrinking–fragmentation–weakening is not accompanied by increases in catchment rainless days (i.e., total DL absence). Like the seasonal rainfall totals, DL size/organization and intensity increase slightly after the mid-1980s.
Financial and operational performance assessment: water/wastewater Egyptian utilities
Authors: Hassanein Amr AG , Khalifa R A 
Published: October 2006

The key problem in most of the water and wastewater utilities is the absence of performance assessment tools. This research utilized the calculation of a group of financial and operational indicators for a sample size of 117 public sector utilities located in the USA, Egypt and developing countries. These indicators are then used to depict the performance of the Egyptian utilities as compared to the sampled utilities. Practical application: The results furnished by the group of the indicators included in the study relay the performance of the Egyptian utilities in comparison to the USA utilities and utilities in developing countries. The results also indicated the resemblance in some performance aspects between the water and water/wastewater utilities in Egypt and the remaining developing countries studied. On the face of it, a significant gap was noticed in most of the results between Egypt and the USA. As an example, the return on sales of Alexandria Water General Authority (AWGA) was less than that of the USA water utilities by 60%. Furthermore, the average tariff charged in the USA was higher than those charged in Egypt by 95% while the tariff charged across the developing countries exceeded the Egyptian tariff by 66%.
Bronchogenic glomangiomyoma with local intravenous infiltration
Authors: Katabami M. , Okamoto K. , Ito K. , Kimura K. , Kaji H. 
Published: October 2006

Most glomus tumours occur in the dermis and subcutaneous tissues. Lung glomus tumours are quite rare.The current authors present the first reported case of a lung-derived glomangiomyoma, the rarest variant of glomus tumour.A 56-yr-old female was admitted with haemoptysis. Chest computed tomography showed an ∼5-cm-diameter mass in the right lower lobe with mucoid impaction. After a right lower lobectomy, a diagnosis of glomangiomyoma was made.The tumour had grown endobronchially and its maximal diameter was 5.5 cm. Although cytologically benign, glomus tumour cells had visibly infiltrated neighbouring vessels. These results suggest that a bronchogenic glomangiomyoma has a low-grade malignancy potential and warrants close follow-up.
Anticoagulation in pulmonary arterial hypertension: a qualitative systematic review
Authors: Johnson S. R. , Mehta S. , Granton J. T. 
Published: October 2006

Thrombotic arteriopathy has been implicated in the pathophysiology of pulmonary arterial hypertension (PAH). However, the role of anticoagulants in the treatment of PAH is uncertain. Through a qualitative systematic review of epidemiological studies, the effectiveness of anticoagulation therapy with warfarin on survival was evaluated in patients with PAH.MEDLINE (1966 to November 2005), EMBASE (1966 to November 2005), bibliographies of included studies and published reviews were searched without language restriction. Epidemiological studies evaluating the effectiveness of warfarin in PAH were included. Studies had to report mortality as an outcome.Seven observational studies evaluating the effectiveness of warfarin comprising 488 patients were identified. Five studies support the effectiveness of anticoagulation therapy, whereas two do not.Data from observational studies suggest that anticoagulation therapy may be an effective intervention in pulmonary arterial hypertension. However, given the methodological limitations and the small number of existing observational studies, a randomised controlled trial is needed in order to definitively address this important clinical issue.
Similar Efficacy for Ovarian Ablation Compared With Cyclophosphamide, Methotrexate, and Fluorouracil: From a Randomized Comparison of Premenopausal Patients With Node-Positive, Hormone Receptor–Positive Breast Cancer
Authors: Ejlertsen Bent , Mouridsen Henning T. , Jensen Maj-Britt , Bengtsson Nils-Olof , Bergh Jonas , Cold Soren , Edlund Per , Ewertz Marianne , de Graaf Peter W. , Kamby Claus , Nielsen Dorte L. 
Published: October 2006

Purpose To compare the efficacy of ovarian ablation versus chemotherapy in early breast cancer patients with hormone receptor–positive disease. Patients and Methods We conducted an open, randomized, multicenter trial including premenopausal breast cancer patients with hormone receptor–positive tumors and either axillary lymph node metastases or tumors with a size of 5 cm or more. Patients were randomly assigned to ovarian ablation by irradiation or to nine courses of chemotherapy with intravenous cyclophosphamide, methotrexate, and fluorouracil (CMF) administered every 3 weeks. Results Between 1990 and May 1998, 762 patients were randomly assigned, and the present analysis is based on 358 first events. After a median follow-up time of 8.5 years, the unadjusted hazard ratio for disease-free survival in the ovarian ablation group compared with the CMF group was 0.99 (95% CI, 0.81 to 1.22). After a median follow-up time of 10.5 years, overall survival (OS) was similar in the two groups, with a hazard ratio of 1.11 (95% CI, 0.88 to 1.42) for the ovarian ablation group compared with the CMF group. Conclusion In this study, ablation of ovarian function in premenopausal women with hormone receptor–positive breast cancer had a similar effect to CMF on disease-free and OS. No significant interactions were demonstrated between treatment modality and hormone receptor content, age, or any of the well-known prognostic factors.
Prospective Study of Urinary Prostaglandin E2 Metabolite and Colorectal Cancer Risk
Authors: Cai Qiuyin , Gao Yu-Tang , Chow Wong-Ho , Shu Xiao-Ou , Yang Gong , Ji Bu-Tian , Wen Wanqing , Rothman Nathaniel , Li Hong-Lan , Morrow Jason D. , Zheng Wei 
Published: October 2006

Purpose Overexpression of cyclooxygenase-2 (COX-2) has been shown to play a major role in colorectal cancer pathogenesis. However, no human study has directly investigated whether biomarkers of COX-2 overexpression may predict colorectal cancer risk. We evaluated the association of urinary prostaglandin E2 metabolite (PGE-M) levels and colorectal cancer risk Methods A nested case-control study was conducted within the Shanghai Women's Health Study, in which 74,942 Chinese women ages 40 to 70 years were recruited from 1997 to 2000. Urinary PGE-M in 150 cohort members who developed colorectal cancer during the follow-up were compared with 150 matched controls. Results The baseline level of urinary PGE-M was more than 50% higher in cases than in controls. The relative risks (RRs) of developing colorectal cancer were elevated from 1.0 to 2.5 (95% CI, 1.1 to 5.8), 4.5 (95% CI, 1.9 to 10.9), and 5.6 (95% CI, 2.4 to 13.5) with increasing quartiles of urinary PGE-M levels (P for trend < .001). The positive association was observed for both colon cancer (RR = 4.9; 95% CI, 1.7 to 14.7 for the highest v lowest quartile; P for trend = .009) and rectal cancer (RR = 7.2; 95% CI, 1.7 to 30.7; P for trend = .048), and for colorectal cancer cases diagnosed in the first 30 months (RR = 7.6; 95% CI, 1.8 to 32.0; P for trend = .035) and subsequent months (RR = 4.4, 95% CI, 1.5 to 13.3; P for trend = .012) of follow-up. Conclusion Given its strong association with colorectal cancer risk, urinary PGE-M may be a promising biomarker for risk assessment of this common malignancy.
Multicenter Randomized Trial of Adjuvant Fluorouracil and Folinic Acid Compared With Surgery Alone After Resection of Colorectal Liver Metastases: FFCD ACHBTH AURC 9002 Trial
Authors: Portier Guillaume , Elias Dominique , Bouche Olivier , Rougier Philippe , Bosset Jean-François , Saric Jean , Belghiti Jacques , Piedbois Pascal , Guimbaud Rosine , Nordlinger Bernard , Bugat Roland , Lazorthes Franck , Bedenne Laurent 
Published: October 2006

Purpose Complete resection of liver metastases of colorectal origin is the only potentially curative treatment. In order to decrease recurrences, the use of adjuvant systemic chemotherapy after liver resection is controversial because no randomized study demonstrated its benefit. Patients and Methods In a multicenter trial, we randomly assigned 173 patients with completely resected (R0) hepatic metastases from colorectal cancer to surgery alone and observation (87 patients) or to surgery followed by 6 months of systemic adjuvant chemotherapy with a fluorouracil and folinic acid monthly regimen (86 patients). The main outcome criterion was disease-free survival. Secondary outcome measures were overall survival and treatment-related toxicity. Results The intention-to-treat analysis was based on 171 patients, after a median follow-up of 87 months (SE = 5.8). The 5-year disease-free survival rate, after adjustment for major prognostic factors, was 33.5% for patients in the chemotherapy group and 26.7% for patients in the control group (Cox multivariate analysis: odds ratio for recurrence or death = 0.66; 95% CI, 0.46 to 0.96; P = .028). With regard to secondary outcome measures, a trend towards increased overall survival was observed but did not reach statistical significance (5-year overall survival: chemotherapy group, 51.1% v control group, 41.1%; odds ratio for death, 0.73; 95% CI, 0.48 to 1.10; P = .13). Conclusion Despite a suboptimal regimen, which was the standard at the beginning of the study, adjuvant intravenous systemic chemotherapy provided a significant disease-free survival benefit for patients with resected liver metastases from colorectal cancer.
Phase III Study of Docetaxel and Cisplatin Plus Fluorouracil Compared With Cisplatin and Fluorouracil As First-Line Therapy for Advanced Gastric Cancer: A Report of the V325 Study Group
Authors: Van Cutsem Eric , Moiseyenko Vladimir M. , Tjulandin Sergei , Majlis Alejandro , Constenla Manuel , Boni Corrado , Rodrigues Adriano , Fodor Miguel , Chao Yee , Voznyi Edouard , Risse Marie-Laure , Ajani Jaffer A. 
Published: October 2006

Purpose In the randomized, multinational phase II/III trial (V325) of untreated advanced gastric cancer patients, the phase II part selected docetaxel, cisplatin, and fluorouracil (DCF) over docetaxel and cisplatin for comparison against cisplatin and fluorouracil (CF; reference regimen) in the phase III part. Patients and Methods Advanced gastric cancer patients were randomly assigned to docetaxel 75 mg/m2 and cisplatin 75 mg/m2 (day 1) plus fluorouracil 750 mg/m2/d (days 1 to 5) every 3 weeks or cisplatin 100 mg/m2 (day 1) plus fluorouracil 1,000 mg/m2/d (days 1 to 5) every 4 weeks. The primary end point was time-to-progression (TTP). Results In 445 randomly assigned and treated patients (DCF = 221; CF = 224), TTP was longer with DCF versus CF (32% risk reduction; log-rank P < .001). Overall survival was longer with DCF versus CF (23% risk reduction; log-rank P = .02). Two-year survival rate was 18% with DCF and 9% with CF. Overall response rate was higher with DCF (χ2 P = .01). Grade 3 to 4 treatment-related adverse events occurred in 69% (DCF) v 59% (CF) of patients. Frequent grade 3 to 4 toxicities for DCF v CF were: neutropenia (82% v 57%), stomatitis (21% v 27%), diarrhea (19% v 8%), lethargy (19% v 14%). Complicated neutropenia was more frequent with DCF than CF (29% v 12%). Conclusion Adding docetaxel to CF significantly improved TTP, survival, and response rate in gastric cancer patients, but resulted in some increase in toxicity. Incorporation of docetaxel, as in DCF or with other active drug(s), is a new therapy option for patients with untreated advanced gastric cancer.
Impact of Prediagnosis Smoking, Alcohol, Obesity, and Insulin Resistance on Survival in Male Cancer Patients: National Health Insurance Corporation Study
Authors: Park Sang Min , Lim Min Kyung , Shin Soon Ae , Yun Young Ho 
Published: October 2006

Purpose Although many studies have demonstrated that smoking, alcohol, obesity, and insulin resistance are risk factors for cancer, the role of those factors on cancer survival has been less studied. Patients and Methods The study participants were 14,578 men with a first cancer derived from a cohort of 901,979 male government employees and teachers who participated in a national health examination program in 1996. We obtained mortality data for those years from the Korean Statistical Office. We used a standard Poisson regression model to estimate the hazard ratio (HR) for survival in relation to smoking, alcohol, obesity, and insulin resistance before diagnosis. Results Poor survival of all cancer combined (HR, 1.24; 95% CI, 1.16 to 1.33), cancer of the lung (HR, 1.45; 95% CI, 1.15 to 1.82), and cancer of the liver (HR, 1.36; 95% CI, 1.21 to 1.53) were significantly associated with smoking. Compared with the nondrinker, heavy drinkers had worse outcomes for head and neck (HR, 1.85; 95% CI, 1.23 to 2.79) and liver (HR, 1.25; 95% CI, 1.11 to 1.41) cancer, with dose-dependent relationships. Patients with a fasting serum glucose level above 126 mg/dL had a higher mortality rate for stomach (HR, 1.52; 95% CI, 1.25 to 1.84) and lung (HR, 1.48; 95% CI, 1.18 to 1.87) cancer. Higher body mass index was significantly associated with longer survival in head and neck (HR, 0.54; 95% CI, 0.39 to 0.74) and esophagus (HR, 0.44; 95% CI, 0.28 to 0.68) cancer. Conclusion Prediagnosis risk factors for cancer development (smoking, alcohol consumption, obesity, and insulin resistance) had a statistically significant effect on survival among male cancer patients.