bluuebunny/crossref_metadata_2025_split huggingface dataset:
Оперативно лечение на глиосарком: клиничен случай
Authors: Ильов Илко , Илиев Богомил , Петров Петър-Преслав , Иванов Кирил , Пенчев Пламен 
Published: March 2024

Глиосаркомът (ГС) е рядък злокачествен тумор от висок клас, който е силно агресивен и в повечето случаи се характеризира с лоша прогноза. Той е необичаен подтип на глиобластом (ГБ), поради което хистологичният анализ е задължителен за поставяне на точна диагноза.
Представяме случай на 71-годишен мъж, който постъпва в клиниката на УМБАЛ „Света Марина“ със силно главоболие, продължаващо от два месеца, придружено от моменти на замаяност, дезориентация и епилептични припадъци. Чрез ЯМР на мозъка е изобразена туморна формация в широчина към твърдата мозъчна обвивка без мозъчен оток, подозрителна за менингиом. Под обща анестезия е направена краниотомия и чрез микрохирургична техника с невронавигация е постигната тотална екстирпация на туморната маса. Въпреки очакванията за менингиом, хистологично е установено, че това е ГС, който показва двуфазен тъканен модел, съдържащ глиоматозен компонент и мезенхимна диференциация. Следоперативно пациентът получи неврологично подобрение, беше без епилептични пристъпи и беше изписан на 5-ия ден. Три седмици след интервенцията пациентът е подложен на лъчетерапия, последвана от химиотерапия. Въпреки лечението, той завършва с exitus lethalis на 7-ия месец след хирургичното лечение.
Ние искаме да преставим такъв рядък и изключителен случай поради факта, че той допринася за медицинските изследвания, подхода към лечението и по-нататъшното проучване на такова изключително заболяване.
Silver-Russell syndrome през погледа на семейния лекар
Authors: Колева Рени , Девлова Диана 
Published: March 2024

Въведение: Silver-Russell syndrome (SRS) е рядко заболяване с честота 1:30 000 до 1:100 000 новородени. Поради изразената клинична хетерогенност голяма част от пациентите с SRS са недиагностицирани. Основните характеристики на синдрома са интраутеринната ретардация и постнаталното забавяне на растежа, дисморфични стигми и малформации на други органи и системи.
Материал и методи: Описваме 7-годишно момиче с клинични данни (интраутеринна хипотрофия, незадоволителен постнатален растеж, по-изразен по отношение на тегло, дисморфични стигми). Диагнозата е потвърдена на 10 м.в. чрез ДНК анализ – 11р15. Започнато е лечение с растежен хормон (РХ) по линия на „Българската Коледа“ на 5 г. 8 м.в.
Резултати: На 7 г.в. стандартните отклонения за ръст и тегло са -0.8. Все още ръстът не съвпада с генетичната прогноза. Изоставането в психомоторното развитие е преодоляно и детето изпълнява критериите за „училищна зрялост“.
Дискусия: Диагнозата SRS е поставена рано благодарение на системните профилактични прегледи и оценката на ауксологичните показатели. Създадени са планове за проследяване на лечението и мониториране на състоянието за семейството и семейния лекар. Акцентите са редовно провеждане на профилактични прегледи, интерпретация на резултатите, активно търсене на симптоми на хипогликемия, странични реакции от лечението с РХ и други вродени състояния.
Заключение: Системните и съвестно провеждани профилактични прегледи и интерпретиране на резултатите са ключов момент за оценка на растежа и развитието на детето, включително и за откриване на редки болести. Съдействието на семейството, доверието към семейния лекар и екипа-консултанти са в основата на отглеждането на дете с рядко заболяване.
Kolaborasi IBM ASMI dengan Dunia Usaha dalam Membantu Mengatasi Pengangguran Pasca Covid-19
Authors: Rumambi Freddy Johanis 
Published: March 2024

Dampak pandemi COVID-19 telah menyebabkan lonjakan jumlah pengangguran secara signifikan di berbagai sektor ekonomi. Kolaborasi antara IBM ASMI dan dunia usaha menjadi sebuah langkah strategis dalam menanggulangi masalah pengangguran pasca COVID-19. Dengan menggabungkan keahlian teknologi dan sumber daya dari IBM ASMI serta pengalaman dan jaringan bisnis dari dunia usaha, kolaborasi ini bertujuan untuk menciptakan peluang kerja baru, memberikan pelatihan dan peningkatan keterampilan kepada para pencari kerja, serta mendorong inovasi dalam menciptakan solusi berkelanjutan untuk memperbaiki ekonomi pasca pandemi. Kolaborasi yang dikembangkan dalam tulisan ini merupakan ringkasan dan analisis laporan kegiatan PKM di dilaksanakan IBM asmi dengan Dunia Usaha dalam kegiatan Community Developmen Training. Peserta kegiatan terdiri dari 40 peserta, yang terdiri dari 30 peserta kelompok siap kerja dan 10 peserta dari kelompok wirausaha. Selanjutnya setelah selesai pelatihan para peserta langsung disalurkan ke Perusahan-perusahan yang terlah bekerja sama dan berkomitmen dengan program ini. Kesimpulan adalah : a)Para Perusahan siap menerima para Peserta yang telah dilatih oleh IBM asmi sesuai bidang keahlian serta kebutuhan perusahan, b) Sebanyak 40 peserta pelatihan yang terdiri dari 30 peserta siap kerja dan 10 peserta kewirausahaan berhasil lulus dengan baik dalam pembelajaran teori maupun praktik. c) Peserta dilatih oleh I nstruktur/Dosendari IBM asmi yang ahli di bidang manajemen, akuntansi, administrasi bisnis, administrasi perkantoran, dan system informasi.
The Process of Revisiting the Classics in Matei Vișniec’s Theatre. Or About the Fragility of Seagulls in Canonical Drama
Authors: Petcu Ioana 
Published: March 2024

Dramatic rewritings—adaptations, updates, additions and hybridizations of genres—have the role of dynamizing the literary substrate and framework, often configuring a bridge between history events or episodes through which a society passes across eras. Matei Vișniec deconstructs and recomposes Shakespearean or Chekhovian characters, reworks the material of classical authors’ plays in a new form on a seemingly improvised frame, contextualising both hypotext and hypertext. Through these returns, a constant dialogue with memory is operated, with the revitalization and remembrance of important moments in the becoming of a culture, a theatre or an artist. Textual improvisations also show themselves as a way of productive reception. Our analysis1 will focus on texts that go through the process of rewriting the classics of universal literature, from The Chekhov Machinery, to Richard III Will Not Take Place or Scenes from the Life of Meyerhold and Why Hecuba—these are plays that revisit texts and characters, melting them into the mould of the present with tragi-comic, grotesque, derisory accents. In a perspective beyond spatial and temporal landmarks, the playwright creates a palimpsest from fragments about humanity across eras, about the great errors West to East of Europe, and themes that cross literary, theatrical and creative borders.
Perbandingan Kadar Flavonoid Total Jarak Pagar (Jatropha curcas L.) dan Jarak Merah (Jatropha gossypiifolia L.)
Authors: Hasan Hamsidar , Hiola Faramita , Nuzul  Ramadhani Fika , Sy.  Pakaya Mahdalena , Tululi Rahmatiya Imran 
Published: March 2024

Flavonoids are a group of phytochemical compounds commonly found in plants. Jatropha curcas L. And Jatropha gossypiifolia L. Are plants belonging to the same family, Euphorbiaceae. Both of these plants have significant potential, especially in health. This research aims to determine the comparison of total flavonoid levels in methanol extracts of Physic Nut (Jatropha curcas L.) and Cotton-Leaf Physic Nut (Jatropha gossypiifolia L.) leavs using U-Vis spectrophotometry method. This research utilizes both qualitative and quantitative analysis methods. The qualitative analysis involves phytocemical screening and Thin-Layer Chromatography analysis using an eluent of n-Hexane ethyl acetate with a ratio of (8:2). The quantitative analysis in this research utilized the UV-Vis spectrofotometry method at a wavelength of 435 nm with quercetin as the standard comparator. The results indicate that the average total flavonoid content in 100 mg of methanol extract from Physic Nut (Jatropha curcas L.) leaves is 5,75% w/v. Meanwhile, in the methanol extract from Cotton-Leaf Physic Nut (Jatropha gossypiifolia L.) leaves, it is 7,20% w/v. Based on Independent Sample T-test statistical analysis, the total flavonoid content in the methanol extract from Cotton-Leaf Physic Nut leaves is significantly higher than that in the methanol extract from Physic Nut Leaves, indieating a significant difference in the average values of two samples (p-value0,05).
Purification of 3×Myc PKG-Puro-Poly A Gene for Bacterial Transformation
Authors: Pahmi Khairil , Sidratullah M. 
Published: March 2024

Dysregulation of the oncoprotein c-Myc (Myc) is involved in many types of cancer. Myc is a sequence-specific transcription factor that regulates the transcription of genes involved in the control of cell proliferation and apoptosis through mechanisms that are not well understood. The method of this research is experimental. The experiment result will be described. Some processes will be done by polymerase chain reaction (PCR) to amplify the gene and then it will be extracted to pure the targeted gene. This research has been succesful to purify 3×Myc PKG-Puro-Poly A gene. c-MYC (hereinafter MYC) is an oncoprotein consisting of 439 amino acids contains a well-characterized C-terminal DNA compound and an N-terminal transactivation domain (TAD). The C-terminal region »100 residues comprises a basic leucine zipper-helix-loop-helix (bHLH-LZ) segment that regulates heterodimerization between MYC and its partner bHLH-LZ MAX mediate in their binding to gene promoters.
The Effect Of Job Training, Work Motivation, And Career Development on Employee Performance at PT. Sinar Harapan Roof Kebun Tebeng Bengkulu City
Authors: Pratiwi Arda , Islamuddin Islamuddin 
Published: March 2024

This study aimed to determine the effect of job training, work motivation, and careerdevelopment on employees’ performance at PT. Sinar Harapan Roof Kebun Tebeng Bengkulu City. This study used quantitive method. The data collection techniques used observation, interview and quitionnaire. The population of this stufy were all employess of PT. Sinar Harapan Roof Kebun Tebeng In Bengkulu City with totaling 32 people by using the saturated sampling technique. The result of study show that multiple linear regression, the regression equation Y = 5.234 + 0.115 (x1) + 0.169 (X2) + 0.009 (X3) is obtained. This equatin can be explained by the positive effect of eavh independent variable, on employees’ performance (Y). as well as the coefficient of determination of R2= 0.675 or around (67.5%) through hypothesis testing together (simultaneously) and individually (partially) and by the F test and T test, job training (X1), work motivation (X2), and career development (X3) are 0.014. it means that the value of fsig<0.05 indicates that together and tahat has a significant effect.
Increasing SMEs Productivity Through Digital Transformation Adoption of Software as a Service and Development of Entrepreneurial Attitudes
Authors: Pradesa Endar , Sakti Ratih Eka , Putri Metha Aditya 
Published: March 2024

This study aims to test the influence digital transformation adoption of Software as a Service cloud accounting services and development of entrepreneurial attitude to productivity SMEs in Lubuklinggau as measured by indicators make transactions easier, speeds up transactions, providing additional profits when completing transaction, increase efficiency in do transaction For variables digital transformation, adoption of Software as a Service cloud accounting services. Planning indicators, beliefs, orientation on task, taking risk, leadership, And honesty For variables development of entrepreneurial attitude . As well as indicator efficiency, effectiveness, and economical for variables SMEs productivity. This research uses the Purposive Sampling method. Deep sample study was 37 respondent SMEs in Lubuklinggau. Data used in this research was primary data obtained from distribution questionnaire directly. This study used a quantitative approach. Analysis data was done using Smart PLS 3. The results of this study indicate that the effect of digital transformation adoption of Software as a Service cloud accounting services and the development of entrepreneurial attitudes on productivity of SMEs in Lubuklinggau influential positive. This study was expected can provide benefits for SMEs in Lubuklinggau with the digital transformation of adopting Software as a Service cloud accounting services so that realization enhancement productivity Which Good and develop attitude entrepreneurial with Good so that productivity increase with good too.
Analysis Of Potential Bankruptcy In Blue Bird Tbk And Transindo Utama Tbk Using Springate And Grover Models
Authors: Sariwati Indah , Fachruzzaman Fachruzzaman 
Published: March 2024

Financial statement analysis is very important for companies. By analysing financial statements, the potential for bankruptcy can be known from the start. Financial statements serve as a source of information for creditors, investors, employees, and other parties in need.In industry 4.0, everything is online, even transport. The object of this research is PT Blue Bird Tbk. and PT Transindo Utama Tbk. The purpose of this study is to determine the company's financial performance in the last five years and potential bankruptcy. The analysis method in this study is the Springate model and the Grover model.The conclusion of this study is that using the Springate model, PT Blue Bird Tbk. in 2018 shows a healthy financial condition, while in 2019-2022 it shows potential bankruptcy. PT Transindo Utama Tbk. in 2018, 2019, 2020, 2022 shows potential bankruptcy, while in 2021 the financial condition is healthy. Then using the Grover model, PT Blue Bird Tbk. shows no potential bankruptcy. PT Transindo Utama Tbk. shows potential bankruptcy in 2018-2020, while in 2021 and 2022 the financial condition is healthy.
Diseño de una Propuesta para la Implementación de Canales de Distribución y Última Milla en la Plaza de Mercado de Facatativá Mediante el Desarrollo de un E-Commerce
Authors: Avila Castillo Maria Alejandra , Obando Guzmán Alison Mayrim , Trujillo Moreno Sandra Ximena , Ortiz González Yenith Cristina 
Published: March 2024

La plaza de mercado de Facatativá es uno de los principales centros de distribución de alimentos en el departamento de Cundinamarca, desde siempre ha marcado tradición y conservación de la cultura dentro del municipio; sin embargo, debido a la transformación digital que ha experimentado el mundo durante los últimos años y la necesidad de adaptarse a esos cambios, es importante que se preserve la plaza de mercado como un sistema organizacional eficiente, productivo, competitivo y sostenible. Por lo anterior, el objetivo del presente estudio, es diseñar una estrategia para la implementación de procesos de distribución y última milla en la plaza de Facatativá mediante un e-commerce con el propósito de diversificar los canales de comercialización y distribución de los productos alimenticios, a través de una metodología desarrollada en tres fases, siendo la primera un diagnóstico de evaluación dinámica de la cadena de suministro que analiza las fuerzas del comportamiento de los actores clave en la plaza de mercado de Facatativá y su respuesta ante las mismas; en la segunda fase se realizó un análisis de la percepción y apropiación de tecnologías mediante la elaboración de un cuestionario enfocado en la adopción del e-commerce y por último se diseñaron estrategias de distribución de última milla.
Diseño de Estrategias para la Innovación de Procesos en la Cadena de Suministro de la Plaza de Mercado de Facatativá
Authors: Avila Jaramillo Laura Nataly , Lancheros Rojas Laura Ximena , Trujillo Moreno Sandra Ximena , Ortiz González Yenith Cristina 
Published: March 2024

El presente estudio tiene como objetivo general diseñar estrategias para la innovación de procesos en la cadena de suministro de la plaza de mercado ubicada en el municipio de Facatativá, a través de una metodología de tipo exploratorio y descriptivo, con método mixto de nivel cuantitativo, desarrollado en tres fases: Diagnóstico con instrumento de recolección de datos y análisis de la información a partir de las cadenas de abastecimiento dinámicas, identificación de factores internos y externo a través de la matriz MEFE y MEFI, y por último diagnóstico y autoevaluación del nivel de madurez de los procesos a partir de la estructura que plantea la ISO 9004:2018 para así diseñar el mapa de procesos que plantea la ISO 9001. Por lo anterior, se evidencia como problemática que la plaza de mercado de Facatativá siendo un lugar tradicional de negocios, con el paso del tiempo ha experimentado cambios, en cuanto a factores económicos, culturales y sociales, ocasionando la falta de eficiencia, productividad, competitividad y sostenibilidad de los procesos identificados. Por ende, se propone para el estudio enfrentar los desafíos analizando el estado actual de los procesos frente al cambio esperado de los mismos teniendo como resultado final la categorización de los procesos en los diferentes niveles tales como estratégicos, misionales y de apoyo y las estrategias para una futura implementación.
Implantación de Válvula Aórtica Transcáteter (TAVI). Sedación y Anestesia Regional: Reporte de Caso
Authors: Núñez Cacho Daniel Alberto , Torres Sosa Manuel Jesús Antonio 
Published: March 2024

Introducción: La estenosis aórtica (EA) por calcificación es la valvulopatía más común en los países desarrollados, teniendo gran relevancia en la población geriátrica. Se caracteriza por la limitación de la eyección del ventrículo izquierdo. La prevalencia reportada a nivel mundial es de 1.3% entre los 65-74 años, 2.8% después de los 75 años y 9.8% entre los 80-89 años. Después de confirmar la estenosis valvular se debe establecer el riesgo quirúrgico del paciente. En pacientes de bajo riesgo se deben considerar la dimension de la estenosis y el tamaño del vaso para elegir el modelo y tamaño de la prótesis basandose en la evaluación ecocardiográfica; así como poder decidir que técnica de reemplazo es más conveniente, ya sea técnica quirúrgica o transcutánea; en pacientes con riesgo intermedio-alto se debe considerar la técnica transcutanea (TAVI) como primer opción debido a que ha demostrado mejores resultados en comparación con la técnica quirúrgica. El manejo anestésico suele ser con el paciente bajo anestesia general o anestesia local y sedación; la elección de la técnica anestésica dependerá de la experiencia del hospital en el procedimiento y preferencia del cirujano. Sin embargo, recientemente hay un incremento en lo reportado en la literatura sobre la seguridad y eficacia de la anestesia local con el paciente bajo sedación consciente. Teniendo ventajas como mayor estabilidad hemodinámica, menor afección en la precarga, disminución en el tiempo quirúrgico, valoración neurológica inmediata, menos días de estancia hospitalaria y disminución en la tasa de mortalidad. Caso clínico: Se presenta un caso clínico de un paciente femenino de 62 años de edad que fue intervenida para implantación de válvula aórtica transcatéter, manejada con sedación endovenosa y bloqueo de nervio femoral. Conclusiones: La técnica anestésica con el paciente bajo sedación ha demostrado ser útil y segura en el manejo de la implantación valvular aórtica transcatéter, teniendo en consideración una adecuada profundidad anestésica para evitar movimientos involuntarios y posibles complicaciones. El bloqueo de nervio femoral tiene utilidad como adyuvante para disminuir las molestias derivadas del abordaje por vía femoral así como brindar analgesia postoperatoria. La terapia antitrombótica es crucial en el seguimiento de los pacientes para prevenir la disfunción valvular.
Effects of the EM CYP2C19 type and MDR1 3435CC gene on Helicobacter pylori eradication rate in patients with duodenal ulcer by the four-drug regimen of rabeprazole, bismuth, tetracycline, and tinidazole
Authors: Nguyen Liem T. , Nguyen Vuong B. , Tran Tu V. , Le Loan T. T. , Phuong Mai H. T. , Nguyen Thang 
Published: March 2024

Background: The MDR1 genotype and the CYP2C19 phenotype determine how much PPI is absorbed from the gut and how much is processed in the liver.
Objective: To assess the impact of CYP2C19 and MDR1 C3435T gene polymorphisms on the efficiency of H. pylori eradication treatment with a 4-drug regimen of rabeprazole, bismuth, tetracycline, and tinidazole (RBTT) in patients with duodenal ulcers.
Methods: The study was conducted at Can Tho University of Medicine and Pharmacy. Gene polymorphisms for CYP2C19 and MDR1 C3435T were detected through a blood test. The RBTT 4-drug regimen was used to eradicate H. pylori.
Results: The success rate of the RBTT regimen for eradicating H. pylori in female patients with the CYP2C19 EM phenotype + MDR1 3435CC genotype was 20.0% lower than the rate of 91.7% for the group without both phenotype and genotype (p = 0.01, OR = 0.02, 95%CI: 0.00–0.45).
Conclusion: Compared to the group lacking both phenotypes and genotypes, female patients with the CYP2C19 EM phenotype + MDR1 3435CC genotype had a lower rate of H. pylori eradication by RBTT regimen.
Enhancing the clinical value of single-phase computed tomography angiography in the assessment of collateral circulation in acute ischemic stroke: A narrative review
Authors: Yang Yunqiu , Wang Zhen , Hu Qingmao , Liu Libo , Ma Guorui , Yang Chen 
Published: March 2024

Abstract:
Acute ischemic stroke (AIS) condition assessment and clinical prognosis are significantly influenced by the compensatory state of cerebral collateral circulation. A standard clinical test known as single-phase computed tomography angiography (sCTA) is useful for quickly and accurately assessing the creation or opening of cerebral collateral circulation, which is crucial for the diagnosis and treatment of AIS. To improve the clinical application of sCTA in the clinical assessment of collateral circulation, we examine the present use of sCTA in AIS in this work.