bluuebunny/crossref_metadata_2025_split huggingface dataset:
Total Synthesis and Antiviral Activity of Enantioenriched (+)‐Deoxytylophorinine.
Authors: Li Hao , Hu Tianshun , Wang Kailiang , Liu Yuxiu , Fan Zhijin , Huang Runqiu , Wang Qingmin 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Aza‐[3 + 3] Annulations. Part 6. Total Syntheses of Putative (‐)‐Lepadiformine (I) and (‐)‐Cyclindricine C (II).
Authors: Wang Jiashi , Swidorski Jacob J. , Sydorenko Nadiya , Hsung Richard P. , Coverdale Heather A. , Kuyava Jennifer M. , Liu Jia 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chiral Synthesis of Poison‐Frog Alkaloids 251N and 221K.
Authors: Toyooka Naoki , Dejun Zhou , Nemoto Hideo , Garraffo H. Martin , Spande Thomas F. , Daly John W. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of (4R,5S)‐Melithiazol C and (3R,4S)‐Cystothiazole E.
Authors: Takayama Hiroyuki , Kato Keisuke , Kimura Masayuki , Akita Hiroyuki 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Formal Synthesis of (‐)‐Centrolobine (I).
Authors: Prasad Kavirayani R. , Anbarasan Pazhamalai 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
ValC, a New Type of C7‐Cyclitol Kinase Involved in the Biosynthesis of the Antifungal Agent Validamycin A.
Authors: Minagawa Kazuyuki , Zhang Yirong , Ito Takuya , Bai Linquan , Deng Zixin , Mahmud Taifo 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis and Evaluation of the Actin‐Binding Properties of Microcarpalide (I) and a Focused Library of Analogues.
Authors: Fuerstner Alois , Nagano Takashi , Mueller Christoph , Seidel Guenter , Mueller Oliver 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Phytochemical Databases of Chinese Herbal Constituents and Bioactive Plant Compounds with Known Target Specificities.
Authors: Ehrman Thomas M. , Barlow David J. , Hylands Peter J. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Common Reference Framework for Analyzing/Comparing Proteins and Ligands. Fingerprints for Liands and Proteins (FLAP): Theory and Application.
Authors: Baroni Massimo , Cruciani Gabriele , Sciabola Simone , Perruccio Francesca , Mason Jonathan S. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Clustering and Rule‐Based Classifications of Chemical Structures Evaluated in the Biological Activity Space.
Authors: Schuffenhauer Ansgar , Brown Nathan , Ertl Peter , Jenkins Jeremy L. , Selzer Paul , Hamon Jacques 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Identification of Potential Small Molecule Peptidomimetics Similar to Motifs in Proteins.
Authors: Baran Ivan , Varekova Radka Svobodova , Parthasarathi Laavanya , Suchomel Simon , Casey Fergal , Shields Denis C. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Analysis of Human Carbonic Anhydrase II: Docking Reliability and Receptor‐Based 3D‐QSAR Study.
Authors: Tuccinardi Tiziano , Nuti Elisa , Ortore Gabriella , Supuran Claudiu T. , Rossello Armando , Martinell Adriano 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Modeling the Interaction Between Two‐ and Four‐Ring Progestin Models and a Silicone‐Based Polymer Model: A Density Functional Theory Study.
Authors: Hukka Terttu I. , Pakkanen Tuula T. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structure‐Based Pharmacophore Identification of New Chemical Scaffolds as Non‐Nucleoside Reverse Transcriptase Inhibitors.
Authors: Barreca Maria Letizia , De Luca Laura , Iraci Nunzio , Rao Angela , Ferro Stefania , Maga Giovanni , Chimirri Alba 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reaction Site Mapping of Xenobiotic Biotransformations.
Authors: Boyer Scott , Arnby Catrin Hasselgren , Carlsson Lars , Smith James , Stein Viktor , Glen Robert C. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Perspective Assessment of COX‐1 and COX‐2 Selectivity of Nonsteroidal Antiinflammatory Drugs from Clinical Practice: Use of Genetic Function Approximation.
Authors: Zambre Ajit P. , Ganure Ashok L. , Shinde Devanand B. , Kulkarni Vithal M. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Facile Preparation, Characterization and Optical Properties of Rectangular PbCrO4 Single‐Crystal Nanorods.
Authors: Cheng Bei , Guo Hua , Yu Jiaguo , Zhao Xiujian 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Discovery of [7‐(2,6‐Dichlorophenyl)‐5‐methylbenzo[1,2,4]triazin‐3‐yl]‐ [4‐(2‐pyrrolidin‐1‐ylethoxy)phenyl]amine — A Potent, Orally Active Src Kinase Inhibitor with Antitumor Activity in Preclinical Assays.
Authors: Noronha Glenn , et al. et al. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthetic Models Related to Furanocoumarin‐CYP 3A4 Interactions. Synthesis of Furanocoumarin Derivatives as Potent Inhibitors of CYP 3A4.
Authors: Oda Kazuaki , Tamai Yukio , Yamaguchi Yuki , Yoshimura Teruki , Wada Keiji , Machida Minoru , Nishizono Naozumi 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Functional Ruthenium(II)‐ and Iridium(III)‐Containing Polymers for Potential Electro‐Optical Applications
Authors: Marin Veronica , Holder Elisabeth , Hoogenboom Richard , Schubert Ulrich S. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Expanding the Diversity of Polycyclic Aromatics Through a Suzuki—Miyaura Cross‐Coupling Strategy
Authors: Kotha Sambasivarao , Lahiri Kakali 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Certain Aspects of the Reactivity of Carotenoids. Redox Processes and Complexation
Authors: Polyakov N. E. , Leshina T. V. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydrogen‐Mediated C—C Bond Formation: A Broad New Concept in Catalytic C—C Coupling
Authors: Ngai Ming‐Yu , Kong Jong‐Rock , Kirsche Michael J. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Application of Hydrolytic Kinetic Resolution (HKR) in the Synthesis of Bioactive Compounds.
Authors: Kumar Pradeep , Naidu Vasudeva , Gupta Priti 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Aryl Calcium Compounds: Syntheses, Structures, Physical Properties, and Chemical Behavior
Authors: Westerhausen Matthias , Gaertner Martin , Fischer Reinald , Langer Jens 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Development of Heat Shock Proteins with Controlled Distribution Properties and Their Application to Vaccine Delivery
Authors: Nishikawa Makiya , Takemoto Seiji , Takakura Yoshinobu 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Development of Effective Antigen Delivery Carrier to Dendritic Cells via Fc Receptor in Cancer Immunotherapy
Authors: Suzuki Ryo , Utoguchi Naoki , Kawamura Kazuko , Kadowaki Norimitsu , Okada Naoki , Takizawa Tomoko , Uchiyama Takashi , Maruyama Kazuo 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Development of Vaccine Adjuvants Using Polymeric Nanoparticles and Their Potential Applications for anti‐HIV Vaccine
Authors: Akagi Takami , Baba Masanori , Akashi Mitsuru 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
N‐(2‐Iodylphenyl)acylamides — New Pentavalent Iodine Oxidizing Reagents
Authors: Ladziata Uladzimir , Zhdankin Viktor V. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Substrates and Biochemical Probes for Study of the Peptidoglycan Biosynthetic Pathway
Authors: Narayan Radha S. , VanNieuwenhze Michael S. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Release Mechanisms for Polyelectrolyte Capsules
Authors: De Geest Bruno G. , Sanders Niek N. , Sukhorukov Gleb B. , Demeester Joseph , De Smedt Stefaan C. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Density Functional Theory with Dispersion Corrections for Supramolecular Structures, Aggregates, and Complexes of (Bio)organic Molecules
Authors: Grimme Stefan , Antony Jens , Schwabe Tobias , Mueck‐Lichtenfeld Christian 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Immune reconstitution inflammatory syndrome in cancer patients with pulmonary aspergillosis recovering from neutropenia: Proof of principle, description, and clinical and research implications
Authors: Miceli Marisa H. , Maertens Johan , Buvé Kristel , Grazziutti Monica , Woods Gail , Rahman Mazhar , Barlogie Bart , Anaissie Elias J. 
Published: May 2007

AbstractBACKGROUND.Assessing the outcome of patients with invasive pulmonary aspergillosis by using conventional criteria is difficult, particularly when clinical and radiologic worsening coincides with neutrophil recovery. Usually, it is assumed that this deterioration is related to progressive aspergillosis, prompting changes in patient management. However, its temporal relation with neutrophil recovery suggests that it may be caused by an immune reconstitution syndrome (IRIS). Galactomannan is an Aspergillus‐specific polysaccharide that is released during aspergillosis and is detected by the serum galactomannan test, which has been approved by the United States Food and Drug Administration for the diagnosis of invasive aspergillosis. In this study, the authors used sequential galactomannan testing to distinguish IRIS responses from progressive aspergillosis.METHODS.From April 2001 to December 2006, patients with hematologic malignancies underwent galactomannan screening during periods when they were at risk. The clinical and laboratory findings from patients who had ≥2 consecutive positive galactomannan assays (optical density, ≥0.5) were reviewed.RESULTS.Nineteen neutropenic patients with aspergillosis developed clinical and radiologic pulmonary deterioration during neutrophil recovery. Deterioration coincided with microbiologic response, as documented by rapid normalization of serum galactomannan, and, in 16 patients, was followed by complete clinical response and survival at 3 months, although there were no changes in antifungal therapy. The 3 patients who died during the first month had no evidence of aspergillosis at autopsy examination.CONCLUSIONS.The authors propose that IRIS was responsible for the current findings and provide a definition for the syndrome. They also recommend serial galactomannan testing to guide aspergillosis management. Declining galactomannan values imply IRIS with an aspergillus response and obviate the need for invasive procedures and alternative antifungal therapies, whereas persistent galactomannan elevation indicates progressive aspergillosis and requires prompt treatment modification. Cancer 2007 © 2007 American Cancer Society.
Resection alone in 58 children with limited stage, lymphocyte‐predominant Hodgkin lymphoma–experience from the European network group on pediatric Hodgkin lymphoma
Authors: Mauz‐Körholz Christine , Gorde‐Grosjean Stephanie , Hasenclever Dirk , Shankar Ananth , Dörffel Wolfgang , Wallace W. Hamish , Schellong Günther , Robert Alain , Körholz Dieter , Oberlin Odile , Hall Georgina W. , Landman‐Parker Judith 
Published: May 2007

AbstractBACKGROUND.Lymphocyte‐predominant Hodgkin lymphoma (LPHL) is a rare, CD20‐positive, good prognostic lymphoma in children. Patients with early‐stage LPHL who underwent successful surgical lymph node resection alone have been reported. To clarify the optimum treatment strategy in children, European study groups were asked to report their experience of surgery alone used in the treatment of pediatric LPHL.METHODS.Data from 58 patients were collected by the French Society for Pediatric Cancers, the German‐Austrian Pediatric Study Group/German Society of Pediatric Oncology and Hematology (Germany), and the Children's Cancer and Leukaemia Group (United Kingdom). In total, there were 50 boys and 8 girls, and the median age was 11 years (age range, 4‐17 years). Fifty‐four patients had stage IA disease, 2 patients had stage IIA disease, and 2 patients had stage IIIA disease.RESULTS.With a median follow‐up of 43 months (range, 2‐202 months), the overall survival rate was 100%, and the progression‐free survival (PFS) rate was 57%. Fifty‐one of 58 patients achieved complete remission (CR) after surgery. In the CR group, the overall PFS rate was 67% (95% confidence interval, 51‐82%). All seven patients who had residual disease after initial surgery developed recurrences (P = .003). Among 18 patients with stage IA LPHL who developed recurrent disease, 11 patients had local recurrences, and 7 patients recurred in stage IIA. One patient with stage IIIA disease presented with high‐grade B‐cell non‐Hodgkin lymphoma at 10 years of follow‐up.CONCLUSIONS.When complete resection was achieved, a substantial proportion of patients with surgically treated, early‐stage LPHL experienced long‐term remission and actually may have been cured. Cancer 2007. © 2007 American Cancer Society.
DTM: a service for managing data persistency and data replication in network‐enabled server environments
Authors: Del‐Fabbro Bruno , Laiymani David , Nicod Jean‐Marc , Philippe Laurent 
Published: May 2007

AbstractNetwork‐enabled server (NES) environments are valuable candidates to provide simple computing Grid access. These environments allow transparent access to a set of computational servers via Remote Procedure Call mechanisms. In this context, a challenge is to increase performances by decreasing data traffic. This paper presents DTM (Data Tree Manager), a data management service for NES environments. Based on the notions of data persistency and data replication, DTM proposes a set of efficient policies which minimize computation times by decreasing data transfers between the clients and the platform. From the end‐user point of view, DTM is accessible through a simple and transparent API. We describe DTM and its implementation in the DIET (Distributed Interactive Engineering Toolbox) platform. We also present a set of experimental results which show the feasibility and the efficiency of our approach. Copyright © 2007 John Wiley & Sons, Ltd.
Integrating and mining distributed environmental archives on Grids
Authors: Zhizhin M. , Kihn E. , Redmon R. , Poyda A. , Mishin D. , Medvedev D. , Lyutsarev V. 
Published: May 2007

AbstractThe solar‐terrestrial physics distributed database for the ICSU World Data Centers, and the NCEP/NCAR climate re‐analysis data have been integrated into standard Grid environments using the OGSA‐DAI framework. A set of algorithms and software tools for distributed querying and mining environmental archives using the UNIDATA Common Data Model concepts has been developed. In addition, the toolkit enables querying the data using meaningful ‘human linguistic’ terms. Copyright © 2007 John Wiley & Sons, Ltd.
Payment and negotiation for the next generation Grid and Web
Authors: Cohen Jeremy , Darlington John , Lee William 
Published: May 2007

AbstractWe present a proposal for a next‐generation Internet based on chargeable Web Services and Utility Computing realized by a series of open but interacting markets. We demonstrate through the U.K. e‐Science project ‘A Market for Computational Services’ the development of some of the fundamental building blocks for such a Grid computational marketplace. This paper describes the motivation behind this restructuring of the Internet and Web‐based activities as a series of markets and how Grid Computing technologies can contribute towards this goal. The paper details the work undertaken at the London e‐Science Centre to build a framework to create and support negotiable and chargeable Web Services. Copyright © 2007 John Wiley & Sons, Ltd.
Inhibition of endogenous MHC class II‐restricted antigen presentation by tacrolimus (FK506) via FKBP51
Authors: Imai Akihito , Sahara Hiroeki , Tamura Yasuaki , Jimbow Kowichi , Saito Tamotsu , Ezoe Kyori , Yotsuyanagi Takatoshi , Sato Noriyuki 
Published: May 2007

AbstractThe effect of tacrolimus (FK506) on down‐regulation of IL‐2 production by T cells is considered to be mainly responsible for its strong suppression of immunological events. In this study, we show that FK506 also has an affect on antigen presentation by antigen‐presenting cells in vitro. FK506 was able to inhibit the presentation of endogenous MHC class II‐restricted minor histocompatibility antigens in primary dendritic cells (DC) in vitro, but cyclosporine A (CsA) and rapamycin (RAP) were not. RNA interference (RNAi)‐mediated reduction of endogenous FK506‐binding protein (FKBP)51 expression resulted in a marked decrease in antigen presentation, suggesting that FKBP51 plays a role in endogenous MHC class II‐restricted antigen presentation. Since our model used naturally expressed cytosolic antigens in primary DC, these effects might have been due to novel properties of the immunosuppressive drugs and may allow us to elucidate a new paradigm for the immunosuppressive mechanism of FK506.
Malondialdehyde modification of myelin oligodendrocyte glycoprotein leads to increased immunogenicity and encephalitogenicity
Authors: Wållberg Maja , Bergquist Jonas , Achour Adnane , Breij Esther , Harris Robert A. 
Published: May 2007

AbstractSelf proteins may become autoantigenic through structural modification. We studied malondialdehydation of recombinant rat (rr) myelin oligodendrocyte glycoprotein (MOG), an autoantigen in multiple sclerosis. Malondialdehyde (MDA) modification changed protein weight and charge, the location of these adducts being mapped by Fourier transform ion cyclotron resonance. Molecular modelling revealed significant differences in the MDA‐rrMOG three‐dimensional structure. DBA/1 mice immunised with MDA‐rrMOG developed greater proliferative responses and more severe experimental autoimmune encephalomyelitis than mice immunised with unmodified rrMOG. MDA‐rrMOG was taken up more effectively by antigen‐presenting cells (APC), at least partially through scavenger receptors. Exposure to MDA‐rrMOG led to increased expression of IL‐23, IL‐12 and IL‐12R, indicating a role not only for increased antigen uptake but also for activation of APC. We thus provide biochemical, structural, immunological and clinical data that suggest that the post‐translationally modified form of this myelin autoantigen is a more relevant form of the molecule.