bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiperistaltic bowel segment for prevention of ileoproctostomy diarrhea
Authors: Tuley R. David , Matolo Nathaniel M. , Garfinkle Sidney E. , Wolfman Earl F. 
Published: February 2007

AbstractPersistent diarrhea accompanied by water, electrolyte, and nutritional depletion and skin excoriation can occur following subtotal colectomy with ileoproctostomy. Attempting to improve the course of these patients, an experimental study using dogs was undertaken to evaluate the use of antiperistaltic ileal segment in the management of ileoproctostomy diarrhea. Subtotal colectomy with ileoproctostomy was performed in dogs. One animal died from weight loss and massive diarrhea with water and electrolyte depletion. The surviving dogs had water and electrolyte imbalance and lost an average of 30.6% of their body weight. A second group of animals was treated identically except that an antiperistaltic ileal segment was placed one foot proximal to ileorectal anastomosis. These dogs maintained their weight and electrolyte and water balance. The stools of these animals became solid, as opposed to the watery diarrhea of the animals with ileoproctostomy only. Ileoproctostomy diarrhea can be successfully controlled by the use of antiperistaltic ileal segment.
Percutaneous transhepatic cholangial drainage: Direct approach under fluoroscopic control
Authors: Takada Tadahiro , Hanyu Fujio , Kobayashi Seiichiro , Uchida Yasuhiko 
Published: February 2007

AbstractWe devised a direct percutaneous transhepatic cholangial drainage under fluoroscopic control. The principle is as follows. After percutaneous transhepatic cholangiography, the three dimensional structure of intrahepatic bile ducts is projected to a two dimensional plane under fluoroscopy; the needle can then be introduced into the selected bile duct with accuracy.The technique can be used as a preoperative management of operations of patients with jaundice and also as a palliative management of advanced cancer without much complication.
Erythropoietin levels in wistar‐furth Wilms' tumor rats
Authors: Murphy Gerald P. , Williams Phyllis D. , Mirand Edwin A. 
Published: February 2007

AbstractErythropoietin (ESF) levels were assayed in rats bearing the Wistar‐Furth Wilms' transplantable tumor. Sites of tumor inoculation varied from subcutaneous, intramuscular, intrarenal (subcapsular), to intra‐peritoneal. Two‐thirds of the animals exhibited ESF elevations without polycythemia, or severe anemia (HCT < 30.0 vol %). The elevations in ESF were not detectably related to the time of sacrifice (age of the animal), size of the primary tumor, or number of gross metastatic foci. The diminished ESF response noted to animals given intramuscular tumor implantations is believed to reflect differences in tumor blood and lymphatic supply at the various sites of inoculation. The pattern of ESF responses in the Wistar‐Furth Wilms' tumor model is thus quite similar to that which we have observed in man, and appears to represent an animal model for tumor‐related ectopic hormone release. The nature of the hormone is believed to differ from that seen in normal physiological states.
Thoracic duct cannulation in a patient with lung cancer
Authors: Takita Hiroshi , Evans James T. , Han Tin , Minowada Jun , Cohen Elias 
Published: February 2007

AbstractPreviously the authors demonstrated limited effectiveness of tumor specific active immunotherapy adjunct to radical surgery in patients with lung cancer.In order to improve the therapeutic effectiveness, a patient with inoperable lung carcinoma was treated with a radical surgery, tumor vaccination, and “unblocking procedures” which consisted of splenectomy and thoracic duct canulation.In vitro studies demonstrated the evidence of sensitization of the patient against his own tumor, removal of blocking factor by the thoracic duct fistula from the circulation.
Frozen section — frozen attitudes
Authors: Webber Banice M. 
Published: February 2007

AbstractThe elimination of frozen section diagnosis will free the patient from one of the great fears of the current treatment of breast cancer ‐ subjecting herself to biopsy without knowing what the outcome will be. It will free the surgeon from the rigid sequence of frozen section followed by mastectomy and allow him to begin to rationally assign patients with proper criteria to conservative treatment, reserving mastectomy for those who do not meet these criteria.
Inhibition of mixed lymphocyte reaction by thoracic duct lymph: Removal of inhibitory effect by thoracic duct drainage in lung cancer
Authors: Han Tin , Takita Hiroshi 
Published: February 2007

AbstractThe inhibitory effect of the thoracic duct lymph of a patient with lung cancer on the “one‐way” mixed lymphocyte reaction without cytotoxicity is unequivocally demonstrated. The effect seems to be dose related. A moderate inhibition of mixed lymphocyte reaction is still observed, even if the responding cells are preincubated in the thoracic duct lymph for 1 hr only prior to the addition of stimulating cells. The inhibitory effect of thoracic duct lymph on the mixed lymphocyte reaction is no longer evident when the material is added 1‐4 days after the beginning of culture. These observations suggest that the mechanism of the inhibitory effect of thoracic duct lymph may be a simple attachment of inhibitory factors to the receptor sites on the responding lymphocytes, causing interference in cell to cell interaction. The inhibitory effect of thoracic duct lymph collected 1 wk after the thoracic duct drainage on mixed lymphocyte reaction is significantly lower than that of thoracic duct lymph collected at the beginning of the procedure. This indicates that the blocking effect of thoracic duct lymph can be easily removed by this technique, which is technically feasible in man. The interrelationship of the tumor‐specific blocking factor, thoracic duct drainage, and tumor growth pattern are discussed with respect to the potential usefulness of this procedure as adjuvant immunotherapy in the management of patients with neoplastic diseases.
Immunologic and chemical studies on mucopolysaccharide derived from murine lymphosarcoma
Authors: Mori Tsuneatsu , Onodera Takashi , Yokota Masanori , Fujii Genshichiro , Inou Tsunamasa 
Published: February 2007

AbstractMucopolysaccharide was prepared from media in which the Gardner's lymphosarcoma cells were cultured. Multiple intraperitoneal injections of the preparation into syngeneic mice resulted in enhancement of the tumors which were inoculated prior to the injections. Sera of these hosts contained antibodies reacting with antigens of the outer layer of the tumor cells.Chemical analyses of the preparation showed that the mucopolysaccharide is composed of hexosamine, uronic acid, hexose, and proteins. The mucopolysaccharide was shown to possess unique migration rate on electrophoresis and thin layer chromatography.
In vitro granulocytic stem cell clonogenic capacity of marrow and spleen cells from mice infected with rauscher leukemia virus
Authors: Koltun Leonard A. , Broxmeyer Hal , Lobue Joseph , Fredrickson Torgny N. , Gordon Albert S. , Gallicchio Vincent 
Published: February 2007

AbstractBone marrow and spleen cells from early, midstage, and terminal Rauscher leukemia virus (RLV‐A)‐infected erythroleukemic mice were assessed for granulocyte stem cell (CFU‐c) clonogenic capacity in the semisolid agar culture assay. It was found that marrow CFU‐c concentrations exceeded normal in early stages of this erythroid disease but returned to near normal values during mid‐ and terminal phases. Splenic CFU‐c concentrations, on the other hand, were generally higher than control values for all stages of the disease. These results are discussed with reference to the pathogenesis of RLV‐A disease.
Immediate postmastectomy reconstruction
Authors: Rosato Francis E. , Fink Paul Jay , Horton Charles E. , Payne Robert L. 
Published: February 2007

AbstractThe role of reconstruction in the management of patients with problems related to breast cancer is of increasing importance. Immediate reconstruction is particularly applicable in those situations where prophylactic mastectomy is performed.High‐risk groups who warrant such prophylactic mastectomy and reconstruction include those with florid cyst disease, a strong family history of breast cancer, the finding of lobular carcinoma in situ, multiple previous biopsies, and those who have severe and progressive mastodynia.In those with smaller amounts of breast tissue, reconstruction is based on a double layer of tissue over a graft, one layer consisting of pectoral muscle and the other of breast skin.In those with more abundant breast tissue, the two layers placed over the graft are both derived from skin flaps, the inner layer a free, denuded dermal graft from the inferior flap and the second layer, the superior breast skin flap itself.
Hemangiopericytoma of the urinary bladder: A case report and review of the literature
Authors: Baumgartner George , Gaeta Juan , Wajsman Zew , Merrin Claude 
Published: February 2007

AbstractA case of hemangiopericytoma arising in the urinary bladder is presented. Initial symptoms included hematuria and frequency of urination. Hemangiopericytoma is a vascular tumor of pericyte origin which occurs primarily in several organs and can be benign or malignant. Reports in the literature of genitourinary system involvement are reviewed. It is concluded that genitourinary tumors of this type should be considered malignant and treated aggressively.
Cell‐mediated immune response in head and neck cancer patients
Authors: Olivari A. , Pradier R. , Feierstein J. , Guardo A. , Glait H. , Rojas A. 
Published: February 2007

AbstractThe immune reactivity of 100 head and neck cancer patients was studied by means of DNCB, candidine, blastic transformation with PHA, and lymphocyte counts.DNCB reactivity was strong in only 21% of the population and was found impaired in patients with advanced primitive tumors, with more than one primitive tumor, and in patients after radiation.Candidine reactivity was impaired in bigger primitive tumors, positive nodes, and advanced stages, as well as in postradiation patients.Blastic transformation was significantly worse in patients over 70 years and tended to be lower in patients with more than one primitive tumor. Good blastic transformation was also lowered in postradiation patients.
Blood coagulation studies during six day heparinless venoarterial bypass in sheep
Authors: Wakabayashi Akio , Woolley Telford O. , Nakamura Yoshimasa , Chen Chi‐Chu , Mullin Paul J. , Fong Susie W. , Connolly John E. 
Published: February 2007

AbstractHeparinless venoarterial bypass (HL‐VAB) was carried out in 16 sheep for 6 days, by means of a closed circuit tubing coated with nonthrombogenic polyurethane‐polyvinyl‐graphite (PPG) and a roller pump. Nine experiments were completed uneventfully. Seven sheep died during bypass. The causes of death were pneumonia (2), caseous granulomatous lung abscess (3) or abdominal abscess (1), and thromboembolism (1). The last complication was caused by inadvertent trauma to the PPG coating at the time of tubing connection.In the animals in which HL‐VAB was uneventful, no significant changes were noted in the hematologic studies including white blood counts, platelet counts, hematocrit, plasma fibrinogen levels, prothrombin time, thrombin time, activated partial thromboplastin time, Factors V and VIII, and free plasma hemoglobin levels.Inconsistant changes in the above parameters were noted in the animals which died of complications.In conclusion, prolonged HL‐VAB has no adverse effects on blood coagulation mechanism.
Rna tumor virus‐like activities in human solid tissues: Endogenous RNA:DNA polymerase activities in the prostate
Authors: Arya S. K. , Zeigel R. F. , Horoszewicz J. S. , Carter W. A. 
Published: February 2007

AbstractSeveral human prostatic tissues have been examined for possible particles and associated DNA polymerizing activity generally associated with the C‐type RNA tumor virus family. Partially purified tissue extracts, when centrifuged to equilibrium in sucrose gradients, yield fractions which contain actinomycin D resistant, endogenous DNA polymerase activity; this activity bands at a density of 1.15‐1.18 gm/cm3. Further analysis of the endogenous products by sucrose gradient sedimentation suggested the presence of high molecular weight RNA:DNA hybrids generally felt to be indicative of a faithful copy of a lengthy stretch of viral specific RNA. However, most of the DNA products synthesized in these endogenous reactions sedimented in much lower molecular weight regions of these sucrose gradients. Clearly, the relative distributions of “high” and “low” molecular weight products could critically depend on the nuclease content of the subcellular fraction under study, and the prostate may be relatively enriched in nucleases. Further, oligo (dT) stimulated the endogenous DNA polymerase activity contained in these extracts, and omission of one of the DNA precursor nucleotides depressed it. Thus, it seems unlikely that terminal transferase activity, rather than genuine DNA polymerization, was being measured primarily. Because of the spectrum of molecular weight classes formed by these DNA:RNA hybrids, as well as their apparent presence in normal prostatic tissue, we find it difficult to ascribe their presence with certainty either to the presence of typical C‐type RNA viruses or to the exclusive behavior of the neoplastic prostatic tissue. Thus, our studies lend support to the growing evidence for functions similar to those of C‐type RNA viruses being relatively widespread in human tissues without the apparent necessity for a possible etiologic role in neoplastic production (Strand and August, 1974; Sherr et al., 1974). At the same time, our current studies emphasize the need for caution in drawing conclusions from results utilizing probes generally felt quite useful in scoring for presence of virus in lower animals at least in the human prostate.
Neuraminidase immunotherapy: Serum potentiation of lymphocyte cytotoxicity related to immunoglobulin levels
Authors: Miller Elizabeth E. , Brown Arthur S. , Johnson Joan L. , Moskovitz Anne , Wallack Marc K. , Rosato Ernest F. , Rosato Francis E. 
Published: February 2007

AbstractSeven patients completed courses of immunotherapy using neuraminidase‐altered autochthonous cells. Their response to therapy was monitored by a cytotoxicity assay using 3 H‐proline‐tagged tumor cells from the patient's own cultured tumor in a strictly autologous system. Serum effects were measured by exposing the tumor target cells to serum to see whether this impeded (blocked) or augmented (potentiated) lymphocyte cytotoxicity. Three of the seven patients developed increasing degrees of serum blocking effect and all died within six months of completing therapy. Four of the seven showed rapidly decreasing blocking and three eventual potentiation. Three patients are living, improved, and free of evidence of tumor. There was an increase in average serum immunoglobulins in patients developing potentiation, and a decrease in those showing blocking. In any immunotherapy program attention must be given to in vitro monitoring studies, and such studies should include attention to the serum factors influencing host response.
Improved liquid cholesterol ester crystal thermography of the breast
Authors: Logan Wende W. , Lind Beverly 
Published: February 2007

AbstractThe infrared detection apparatus used in breast thermography is relatively costly and therefore is not widely available to less populated areas in the country. The use of liquid cholesterol crystals, applied to the breast (applied over a water‐base black dye) has already been described in the literature as an effective substitute for infrared instrument thermography. This method, however, has been hampered by the time and troublesome effort necessary for removal of the substances upon completion of the study.The object of this study was to devise a feasible method of cutaneous breast thermography using liquid cholesterol esters, as in prior studies, but by applying them to an easily removable black base. As a result the length of the examination has been shortened, and patients have found the examination to be aesthetically more acceptable. With this improved method, liquid crystal thermography of the breast (and other areas) should become more widely applicable.
Radiation‐induced peritoneal mesothelioma
Authors: Babcock Terence L. , Powell Darryl H. , Bothwell Roger S. 
Published: February 2007

AbstractA case report of a patient who developed peritoneal mesothelioma 7 years after internal and external irradiation for carcinoma of the cervix is reported. No previous reports of induction of this tumor by irradiation have been found. The subject of radiation‐induced tumors and peritoneal mesothelioma is briefly discussed.
The closure of abdominal wounds in cancer patients
Authors: Gallitano Alphonse L. , Kondi Edward S. 
Published: February 2007

AbstractA total of 102 abdominal surgical wounds in cancer patients were closed with absorbable suture material. The object of the study was to evaluate whether patients with cancer having possible wound healing impairments could be closed with absorbable sutures, thereby omitting the difficulties involved with retention sutures or nonabsorbable material. Polyglycolic acid sutures were used in the fascia in all of these patients, and they were studied regarding the incidence of wound infection, wound dehiscence, and incisional hernias. There were no instances of wound dehiscence in the entire series. A wound infection rate of 14.8% was encountered. The incidence of incisional hernia following either infection or primary healing was noted to be markedly decreased. The rate of wound dehiscence and wound hernia was sufficiently low to lead us to recommend this type of abdominal wound closure in all cancer patients.
Adenosine‐aminohydrolase activity in the erythrocytes, lymphocytes, and plasma of healthy subjects and kidney transplant recipients
Authors: Keogh Brian , Pauly John , Tritsch George , Mittelman Arnold , Murphy Gerald P. 
Published: February 2007

AbstractAdenosine‐aminohydrolase activity in the red blood cells and lymphocytes of transplant patients were assayed by continuous flow analysis. This enzyme, which has been implicated in the ability of lymphocytes to mount an immune response, was evaluated in renal allografted patients immunosuppressed by azothioprine and methylprednisone. Red cell adenosine‐aminohydrolase activity was depressed in all patients when compared to nontreated healthy controls. Adenosine aminohydrolase activity was raised in the lymphocytes of the renal allografted patients. Renal transplant patients' in vitro lymphocyte reactivity to antigens, mitogens, or skin testing to specific antigens, confirmed the depressive effects of immunosuppression observed in vivo. We conclude from these studies that red cell adenosine‐aminohydrolase activity may be a more sensitive index of the state of immunoresponsiveness than the corresponding enzyme activity in the lymphocyte.
Metastatic patterns of cancers of the lymphopoietic system in man
Authors: Viadana Enrico 
Published: February 2007

AbstractAutopsy records are analyzed for 358 patients with reticulum cell sarcoma, lymphocytic lymphosarcoma, or Hodgkin's disease. These records belong to a series of 4,728 autopsy records collected by the Department of Pathology at Roswell Park Memorial Institute from 1957 through 1965.This paper analyzes the distribution of metastases at specific sites in 3 malignant lymphomas. The concept of soil specificity is discussed in connection with the excess of metastases at specific sites. Soil specificity is defined as a higher than expected occurrence of metastases due to a cancer in an organ when compared to other similar primary cancers. In some instances, however, the excess of metastases in a specific site was sometimes also related to the site of origin of a malignant lymphoma. Entire series of organs located either in the abdomen or pelvis showed metastatic patterns which were very likely related to the primary sites of origin.The metastatic patterns of lymphocytic lymphosarcoma and reticulum cell sarcoma appeared to be markedly different from those of Hodgkin's disease. Reticulum cell and lymphocytic lymphosarcomas were not only more widespread than Hodgkin's disease, but the patterns of abdominal and pelvic metastases strongly suggested either their multifocal origin or a different sequence of events in the seeding of lymph node areas, as compared to those of Hodgkin's disease. The relationship between the degree of anaplasia of certain lymphomas and blood‐borne metastases is discussed.
Serum ribonuclease in patients with lung carcinoma
Authors: Marabella Patrick C. , Tritsch George L. , Moore Robert H. , Takita Hiroshi 
Published: February 2007

AbstractFifty‐one previously untreated cases of lung carcinoma and 7 normal healthy controls were evaluated with respect to serum ribonuclease (S‐RNase) levels. Cellular immunity was tested in 22 of these 51 cases by leukocyte migration inhibition test (MIT) using extract of culture cell line of lung carcinoma.S‐RNase levels in lung carcinomas were significantly elevated. There appeared to be no difference in S‐RNase levels by histological classification. More striking was high S‐RNase level in disseminated versus localized cases. MIT results indicated impairment of cellular immunity in those cases of more elevated S‐RNase. S‐RNase may be implicated in blocking phenomenon associated with neoplastic disease.
Obesity obscuring breast cancer: A case report
Authors: Ariel Irving M. , Greenberg Joseph 
Published: February 2007

AbstractThere is normally a layer of fat in the breast between the parenchyma of the breast and the skin. This is frequently thin and does not preclude the palpation of a tumor mass which involves the breast parenchyma. In patients suffering from obesity this fat pad becomes much thicker and obscures any underlying masses arising from the breast parenchyma. A case is reported in which a woman who was markedly obese lost a significant amount of weight and presented a bulge which was found to be carcinoma. This situation, in which fat obscures underlying breast lesion, has been observed in a number of patients. Attention is called to the limited value of physical examination of the breast in markedly obese patients. If any suspicion exists or if the patient is a candidate for cancer from a familial standpoint, mammograms are indicated.
Changes in blood viscosity and plasma proteins in carcinoma
Authors: Tietjen George W. , Chien Shu , Scholz Peter , Gump Frank E. , Kinney John M. 
Published: February 2007

AbstractBlood viscosity and plasma protein concentrations were measured in 31 patients with a variety of visceral carcinomas.The mean whole blood viscosity was not elevated over normal controls because of a significantly lowered mean hematocrit. However, when hematocrit was eliminated as a variable by adjusting the hematocrit to 45%, the mean whole blood viscosity was significantly elevated in the group with carcinoma. Both the plasma viscosity and the tendency for red cell aggregation were significantly elevated in the group with carcinoma. The fibrinogen and globulin fractions were also significantly elevatedSince blood is a non‐Newtonian fluid, and its viscosity increases markedly at low shear rates, these rheological abnormalities would be most important at the low shear rates characteristic of the venous circulation. It is suggested that these abnormalities in blood viscosity and red cell aggregation may be contributing to the high incidence of venous thromboembolism seen in patients with neoplastic disease.