bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of hyperhomocysteinemiaon carotid intima-media thickness in type 2 diabetes mellituswith or without hypertension: a retrospective observational study
Authors: Ao Li , liu Ling , Suo Lixia , Liang Dongyu , Niu Jingya , Yang Qin , Ren Dongmei 
Published: March 2024

Abstract
Background: The influence of hyperhomocysteinemia on carotid intima-media thickness (CIMT) in patients with type 2 diabetes mellitus (T2DM) and its interplay with hypertension remains uncertain. This study aimed to investigate the impact of hyperhomocysteinemia on CIMT in patients with T2DM, both with and without coexisting hypertension.
Methods: This retrospective observational study was conducted at Shanghai Jiading District Central Hospital, enrolling patients with type 2 diabetes mellitus (T2DM) between January 2019 and December 2020. Data on serum homocysteine levels and carotid intima-media thickness (CIMT) were collected. Multivariable logistic regression analysis was employed to investigate the potential risk factors associated with CIMT in the entire cohort of T2DM patients and within specific hypertension subgroups.
Results: The study sample comprised 423 patients diagnosed with T2DM, with a mean age of 59.99±14.59 years, including 258 males (60.99%), 258 hypertension patients (60.99%). Multivariable logistic regression analysis revealed a significant association between hyperhomocysteinemia and carotid intima-media thickness (CIMT) in all T2DM patients (odds ratio [OR]=2.942, 95% confidence interval [CI]: 1.356-6.386, P=0.006) and among patients with coexisting hypertension (OR=2.840, 95%CI: 1.153-6.999, P=0.040). However, no significant association was observed between hyperhomocysteinemia and CIMT in patients without hypertension (OR=1.123, 95%CI: 0.329-3.383, P=0.194).
Conclusion: The findings highlight hyperhomocysteinemia as an independent risk factor for CIMT thickening in patients with T2DM, particularly among those with concomitant hypertension. These results underscore the importance of managing hyperhomocysteinemia in T2DM patients, particularly those with hypertension, to mitigate the risk of CIMT thickening and subsequent cardiovascular events.
Arabidopsis SDG proteins mediate Polycomb removal and transcription-coupled H3K36 methylation for gene activation
Authors: Yamaguchi Nobutoshi , Yicong Wang , Abe Masato , Kadoya Yuka , Saiki Takeru , Imai Kanae , Wang Xuejing , To Taiko , Inagaki Soichi , Suzuki Takamasa , Kakutani Tetsuji , Ito Toshiro 
Published: March 2024

Abstract

Polycomb Repressive Complex 2 (PRC2) recognizes Polycomb response elements (PREs) and catalyzes trimethylation of histone H3 on lysine 27 (H3K27me3) for gene silencing. This silencing is counteracted by H3K36 methylation for epigenetic activation of gene expression. Here, we show that the Arabidopsis thaliana H3K36 methyltransferases SET DOMAIN-CONTAINING PROTEIN 7 (SDG7) and SDG8 antagonize PRC2-mediated silencing and establish H3K36 methylation patterns with the general transcription machinery. The sdg7 sdg8 double mutant shows developmental defects and lower H3K36me2 and H3K36me3 levels. SDG7 preferentially binds near PREs, but SDG8 is recruited to H3K36 methylation peaks. The sdg7 sdg8 phenotypes are partially rescued by loss of Polycomb function. SDG7 overlaps with PRC2 and its recruiters on chromatin and evicts them from shared target genes when conditionally induced. SDG8 and RNA Polymerase II associate at SDG- and RNA POLYMERASE II ASSOCIATED FACTOR 1 complex-regulated targets for H3K36 methylation and transcription. These results suggest that SDG proteins evict PRC2 from PREs to prevent H3K27me3 deposition and activate target genes via transcription-coupled H3K36 methylation.
Plasma Ionomic Profile and Interaction Patterns in Coronary Artery Disease Patients
Authors: Zhao Qing-Qing , Shu Xian-Long , Yuan Zhen , Gao Qian , Huang Ying , Yang Yuan-Qing , Li Ming-Peng , Wang Guo , Chen Xiao-Ping , Chen Bi-Lian , Tang Jie 
Published: March 2024

Abstract
Humans are exposed to various chemical elements that have been associated with the development and progression of diseases such as coronary artery disease (CAD). However, existing research has primarily focused on the relationships between individual elements and CAD without considering the overall ionomic profile. Therefore, our aim is to employ a multi-element approach to investigate CAD patients and those with comorbid conditions such as diabetes (CAD-DIA), high blood pressure (CAD-HBP), or high blood lipids (CAD-HBL). Plasma concentrations of 21 elements, including lithium, boron, aluminum, calcium, titanium, vanadium, chromium, manganese, ferrum, cobalt, nickel, copper, zinc, arsenic, selenium, strontium, cadmium, stannum, stibium, barium, and plumbum, were measured in CAD patients (n = 201) and healthy subjects (n = 110) using inductively coupled plasma-mass spectrometry (ICP-MS). Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) models were utilized to analyze the ionomic profiles. Spearman correlation analysis was employed to identify the interaction patterns among individual elements. We found that levels of Ba, Li, and Pb were elevated in the CAD group compared to the healthy group, while Sb, Ti, Fe, and Se were lower. Furthermore, the CAD-DIA group exhibited higher levels of Ni and Cd, while the CAD-HBP group showed lower levels of Co and Mn. In the CAD-HBL group, Ti was increased, whereas Ba, Cr, Cu, Co, Mn, Ni, and Ti were reduced. In conclusion, ionomic profiles can be utilized to differentiate CAD patients from healthy individuals, potentially providing insights for future treatment or dietary interventions.
Group 2i Isochrysidales thrive in marine and lacustrine systems with ice cover
Authors: Wang Karen J , Huang Yongsong , Kartzinel Tyler , Majaneva Markus , Richter Nora , Liao Sian 
Published: March 2024

Abstract
Global warming is causing rapid changes to the cryosphere. Predicting the future trajectory of the cryosphere requires quantitative reconstruction of its past variations. A recently identified sea-ice-associated haptophyte, known as Group 2i Isochrysidales, has given rise to a new quantitative sea-ice proxy with its characteristic alkenone distributions. However, apart from the occurrence of Group 2i Isochrysidales in regions with sea ice, and the empirical relationship between C37:4 alkenone abundance and sea-ice concentration, little is known about the ecology of these haptophyte species. Here, we systematically mapped the spatial and temporal occurrence of known Group 2i Isochrysidales based on environmental DNA and alkenones in both marine and lacustrine environments. Our results indicate Group 2i is widely distributed in icy marine and lacustrine environments in both Northern and Southern Hemisphere, but absent in ice-free environments. Temporally, Group 2i is part of the sea-ice algae bloom during the cold seasons, in contrast to other Isochrysidales that bloom in open waters during warm seasons. Our results indicate that ice is a prerequisite for the occurrence of the psychrophilic Group 2i haptophytes in marine and lacustrine ecosystems and further affirms its value for past ice reconstructions.
Results Comparison of Cervical Cancer Early Detection Using Cerviray with VIA Test
Authors: Harsono Ali Budi , Susiarno Hadi , Suardi Dodi , Mantilidewi Kemala Isnainiasih , Wibowo Viko Duvadilan , Hidayat Yudi Mulyana 
Published: March 2024

Abstract
Objectives
This study investigates the performance of Cerviray A.I. and evaluation of Cerviray A.I. by an expert, an artificial intelligence (AI) technology for diagnosing cervical cancer, aiming to compare its sensitivity, specificity, positive predictive value (PPV), and area under the receiver operating characteristic curve (AUC ROC) with the Visual Inspection with Acetic Acid (VIA) test.
Results
The study involved 44 patients from various health centers in West Java Province. Cerviray A.I., evaluation of Cerviray® A.I. by an expert, and VIA tests were administered to high-risk women of childbearing age. Preliminary results indicated that Cerviray A.I. had a sensitivity of 42.9%, specificity and PPV of 100%, and an AUC ROC of 71.4%. In comparison, the evaluation of Cerviray by an expert demonstrated a sensitivity of 71.4%, specificity of 97.3%, PPV of 83.3%, and AUC ROC of 84.4%. Evaluation of Cerviray A.I. by an expert outperformed Cerviray A.I. in AUC ROC.
Utilization of Cervical Cancer Screening and associated factors among HIV-positive Women attending Public Hospitals in North Shoa, Ethiopia, mixed study
Authors: Chuko Bacha Merga , Gindaba Mitiku Yonas , Marami Shambal Negese , Feyisa Mulugeta , Kibrat Fikiru Assefa , Geda Gebreyes Mengistu 
Published: March 2024

Abstract

Introduction
Cervical cancer screening is used to find changes in the cells of the cervix that could lead to cancer. Despite, screening is one of the secondary preventive strategies, the case is still growing. Therefore, the study aimed to assess the utilization of cervical cancer screening services and associated factors among Women living with human immunodeficiency virus at public hospitals in North Shoa, Ethiopia, 2022.
Methods and materials:
A mixed-study method among 396 women was conducted from April 1-June 25, 2022. Systematic random sampling was used to select women for face–to–face interviews and purposive sampling was used to select 18 mothers for in-depth interviews. The bivariate and multivariate logistic regression analyses were done. The data were collected through the face-to-face interview by a structured questionnaire. For analysis, the data were entered into Epi data version 4.6 and exported to Statistical Package for the Social Sciences version 26 software. Bivariate analysis for candidate variables selection (p< 0.25) was used. Multivariable analysis for p-value < 0.05 and 95% confidence level were considered as significantly associated. Results: The proportion of cervical cancer screening utilization among HIV-positive women was 12.1%, 95% confidence interval of 9%- 15%. Variables like an age between 40-49 years [AOR = 3.65; 95%CI=1.20, 11.07], having college above educational level [AOR = 3.04; 95% CI: 1.05, 8.80], Urban residents [AOR = 3.49; 95%CI=1.64, 7.44], and having good knowledge [AOR 3.9; 95%CI: 1.70, 8.83] were significantly associated with utilization of cervical cancer screening service. Service interruption, poor awareness, and rumor were barrier of utilization of cervical cancer screening among HIV-positive women. The results were presented by tables, text, and charts.
Conclusion and recommendation:
The finding of this study showed that only one in ten HIV-positive women was screened. We recommend that increasing women’s knowledge about cervical cancer screening, particularly targeting the younger ones, is crucial to enhance the utilization of screening and promote health education among rural women so that recommended cervical cancer screening can be utilized more effectively.
Grasspea (Lathyrus sativus L.) - a potential leafy vegetable of eastern India
Authors: Tripathi Kuldeep , Kumari Shubha , pamarthi Ravi , Mukherjee A , KR Ramya , Bhardwaj Rakesh , PANDA RINKY RESMA , Semwal DP , Bhatt KC , Viswakarma P , Gautam Raj , Singh PK 
Published: March 2024

Abstract

Grasspea (Lathyrus sativusL.) locally known as “Khesari” was extensively cultivated in Eastern parts of India i.e. Eastern U.P, Bihar, Jharkhand and West Bengal. This study focuses on the exploration, collection, and survey of grasspea as leafy vegetable with the aim of revitalizing traditional knowledge for practical applications. The data on collected grasspea samples (46 accessions) from five germplasm expedition missions were presented in the study. These were subjected to garret ranking and biochemical profiling along with organoleptic evaluation. The findings of the study elucidated that the preference of grasspea consumption in the descending order: leafy vegetable > pulse > fodder > by-products/ processed product. The nutritional profiling of leaves of selected accessions of grasspea were assessed for proximate parametrs. This comprehensive study provides valuable insights into use and preferences associated with grasspea consumption in Eastern India, paving the way for practical applications and the revival of traditional knowledge.
The Impact of Industry Expertise Independent Directors on Corporate Financialization: The Case of Chinese Nonfinancial Corporations
Authors: He Xingxing , Qin Lanli , Sun Yu , Zhang Fenghui 
Published: March 2024

Abstract

China's economic development has faced multiple challenges, such as the weakening of traditional growth momentum, frequent risks in the financial sector, and prominent structural contradictions, and the phenomenon of capital flow from real enterprises to the virtual economy has become more and more prominent This paper takes A-share non-financial listed companies from 2010 to 2022 as the research object, and empirically examines the impact of industry expert independent directors on corporate financialization The results show that industry expert independent directors can effectively inhibit the financialization of enterprises, and the inhibition effect is more prominent in non-state-owned enterprises .The industry expert independent directors can inhibit the financialization of enterprises by narrowing the gap between corporate operating income and financial income, and alleviating internal and external financing constraints In addition, the higher the degree of marketization of the company's location, the stronger the inhibitory effect.
Research on Automatic Generation Technology of Cooling Channels for Injection Mold of Automotive Interior Door Panel
Authors: Wang Jing , Wu Haojie 
Published: March 2024

Abstract

The automotive interior door panel is an important injection molded part in automotive interiors, and a good cooling system is crucial to ensure its molding quality. In fact, due to the complex structure of the automotive interior door panel mold, designing hundreds of cooling channels inside it is often a very tedious and time-consuming task. For a long time, designers can only rely on basic modeling tools and build cooling channels through a large number of interactive operations, which will require a lot of time and effort. To solve this problem, this paper proposes an automatic generation method for cooling channels from a practical perspective based on the basic structural characteristics of cooling channels and the basic rules of mold cooling system design. The basic idea is to first offset adjacent boundary lines on the side of the mold core, and generate a series of scan lines starting from the intersection of the offset lines; Then generate channel entities with specified channel diameters along the scanning line, and perform interference checks on all generated channels; Finally, optimize the positions of all channels and remove unsuitable ones. Experimental results show that this method is simple and practical, and can quickly generate cooling channels that meet the requirements, greatly saving design time, reducing design errors, and improving design efficiency.
Linking Fatty Acid Metabolism to Diabetic Cardiomyopathy: The Role of Mitochondrial Dysfunction and Immune Microenvironment Alterations, a Bioinformatics Approach
Authors: Ni Tingjuan , Huang Xingxiao , Pan Sunlei , Wu Ziliang , Wu Xixi 
Published: March 2024

Abstract
Background
Diabetic cardiomyopathy (DCM) stands as a prevalent cardiovascular complication of diabetes and a primary contributor to mortality among diabetic patients. The pathogenesis of DCM is intricately linked to both fatty acid metabolism (Facm) and immune-inflammation; however, the interplay between these factors in the context of DCM remains a subject of ongoing inquiry. This study seeks to delineate the unique contributions of fatty acid metabolism and the immune microenvironment, as well as their interconnectedness in the progression of DCM, utilizing bioinformatics methodologies.
Methods
The RNA expression dataset for DCM was acquired from the NCBI GEO database. Following data preprocessing, differentially expressed genes (DEGs) between the DCM and control group were identified and overlapped with genes related to fatty acid metabolism genes (Facms). The CIBERSORT algorithm was employed to assess immune infiltration within the cardiac tissue. Finally, validation analysis was carried out using animal and cell models. A mice DCM models was developed to authenticate the expression of hub FacmDEGs and their correlation with cardiac function.
Results
Five hub FacmDEGs (Acot2, Eci1, Ehhadh, Acaa2 and Hadha) were identified as closely linked to DCM. Despite the absence of significant differences in immune cell infiltration demonstrated between the DCM and control (CON) groups in myocardial tissue, the results of immune infiltration analysis revealed a close association of the five hub FacmDEGs with immune cells, especially Th1 Cells and DC Active cell. In the animal and cell experiment, the expression of Acot2 and Eci1 were found to be in accordance with the results of the bioinformatics analysis. Furthermore, the up-regulation of Acot2 and Eci1 was distinctly associated with mitochondrial dysfunction and cardiac dysfunction.
Conclusions This study has unveiled the complicated interaction between fatty acid metabolism and the immune microenvironment in DCM through the lens of mitochondrial dysfunction, providing novel insights into the underlying pathogenesis of DCM and opening avenues for exploring new targets for pharmacological interventions.
The arming of NK cells with Fc-engineered rituximab confers them specificity against CD20-expressing cells
Authors: Villalba Martin , Constantinides Michaël , Coënon Loïs , de Maudave Alexis Fayd'Herb , Multrier Caroline , Campos-Mora Mauricio , Jacquard Carine , Gao Fei , Martineau Pierre , robert bruno , Cartron Guillaume 
Published: March 2024

Abstract
Clinical effects of IgG1 monoclonal antibodies (mAb) relies on various mechanisms, including antibody dependent cell-mediated cytotoxicity (ADCC), which requires natural killer (NK) cells as the main immune effectors. These cells are emerging as significant tools for cancer cell therapies, presenting a potential alternative to Chimeric Antigen Receptor-T (CAR-T) cell therapies. We generated in vitro expanded NK cells (eNK) and investigated the feasibility of loading them with a Fc-modified rituximab (RTX) displaying high affinity for CD16a. We demonstrated that the Fc modified RTX (SDH-RTX: S239D/H268F/S324T/I332E) can be effectively loaded onto eNK cells, resulting in what we termed “armed eNK”. The SDH-RTX-armed eNK retained SDH-RTX in the presence of physiological concentrations of IgG1 and exhibited specific cytotoxic activity against CD20-positive cells, including cell lines and samples from NHL and B-CLL patients. Remarkably, armed eNK cells demonstrated comparable ADCC to eNK cells in the presence of an excess of RTX. Importantly, arming eNK cells did not compromise their natural cytotoxicity against other target cells. These findings pave the way to innovative approaches utilizing armed eNK as a form of “non-genetically modified CAR-like” NK cells to treat diseases susceptible to mAb targeting. This approach offers the advantages of reduced mAb requirement and versatile specificity.
SCECA U-Net Crop Classification for UAV Remote Sensing Image
Authors: yan Hangjia , Liu Gang , Li Zhe , Li Zhi , He Jing 
Published: March 2024

Abstract
Accurately identifying crop distribution is beneficial for assessing crop growth,yield,and disasters. Crop identification is influenced by terrain and complex ecological environments,considering the challenges posed by traditional remote sensing methods such as cost,sensitivity to westher conditions, and limitations in accurately extracting crop festures.Therefore,we selected unmanned aerial vehicle(UAV) remote sensing images of Majiaoba Town, Mianyang City,Sichuan Province,China,aiming to identify and classify various crops in the region,including soybeans,corn,rice,ginger and walunts.We propose using theVGG-16 (Visual Geography Group Network-16) architecture as the main framework,enhancing it by integrating efficient channel ateention(ECA) modules into the U-Net model.It is worth noting that the improved model achieved an impressive F1-Score of 0.78,emphasizing its effectiveness in crop classification. Experimental results show that the method achieves a comprehensive classification accuracy of 79.44% and an average cross-combination rate of 0.64.Our approach outperforms traditional U-Net,PSPNet(Pyramid Scene Parsing Network),and deeplabv3+ models in terms of classification accuracy and metrics, highlighting its advantages in crop identification.
Are competitive interactions between aphid clones mediated by facultative endosymbionts?
Authors: Moya-Hernández Mario G. , Rubio-Meléndez María E. , Zepeda-Paulo Francisca A. , Ramírez Claudio C. 
Published: March 2024

Abstract

Bacterial endosymbionts are key components of aphid biology, as they modify several traits of their insect hosts. Here we studied how bacterial facultative endosymbionts affect the competitive interactions between aphid clones. To address this, we studied intraclonal and interclonal interactions between the two most common clones (G1 and G2) of the cereal aphid Sitobion avenae (Fabricius), including the role of the facultative endosymbiont Regiella insecticola in the outcome of these interactions in a shared host (wheat). The results of this study reveal significant variability in the population growth rates of aphid clones under competitive and non-competitive environments. That trade-off in competitive interactions among aphid clones can influence the dynamics of aphid populations and impact on plant growth and structure. While facultative endosymbionts like R. insecticola do not play a significant role in directly mediating the competitive interactions of aphid clones or affecting specific plant traits, their presence does enhance aphid performance. Aphids harbouring R. insecticola showed higher growth rates in various coexistence scenarios and across different clones with a concurrently reduced capacity to damage host plants, which suggests that R. insecticola produces ecologically relevant consequences for aphids in cereal fields.
Dams are old and abandoned, are people concerned? Risk perceptions from Michigan, USA
Authors: Mayer Adam Peter , Schooley Jackson , Parks Perry , Lopez Maria Claudia , Moran Emilio 
Published: March 2024

Abstract
Dams across the U.S. are in a precarious state. Many have been in disrepair for decades and the entities that built them have long since disappeared, raising difficult questions as to who will manage this growing problem. Despite the state of the nation’s dams, we know very little about public perceptions of dams. In this analysis, we evaluate public concern for dams using survey data from Michigan, a state with an extensive network of aging dams. Using a survey experiment, we find that risk perceptions increased when respondents were provided information about the age of the dams. Respondents identified as “news junkies” also expressed higher risk perceptions. We also tested for “white male” and partisan effects on risk perception but found little evidence of those. We conclude by discussing implications for policy and the future of dam management.