bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperthermic intraperitoneal chemotherapy with and without cytoreductive surgery for epithelial ovarian cancer
Authors: Helm C. William , Bristow Robert E. , Kusamura Shigeki , Baratti Dario , Deraco Marcello 
Published: August 2008

AbstractWomen with epithelial ovarian cancer (EOC) usually present with advanced disease and overall only just over half survive 5 years. Even following a complete response to front‐line treatment two‐thirds will recur, with a resultant dismal prognosis. We review and discuss the role of surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in EOC and present the results of the ovary consensus panel (OCP) convened for the 5th International Workshop on Peritoneal Surface Malignancy. J. Surg. Oncol. 2008;98:283–290. © 2008 Wiley‐Liss, Inc.
A prospective study of trait anger and PTSD symptoms in police
Authors: Meffert Susan M. , Metzler Thomas J. , Henn‐Haase Clare , McCaslin Shannon , Inslicht Sabra , Chemtob Claude , Neylan Thomas , Marmar Charles R. 
Published: August 2008

AbstractIt is unknown whether anger is a risk factor for the development of posttraumatic stress disorder ( PTSD) symptoms, arises as a consequence of PTSD, or both. Two hypotheses were tested in 180 police recruits: Greater trait anger during training will predict greater PTSD symptoms at one year; greater PTSD symptoms at one year will predict greater state anger at one year. Both hypotheses were confirmed, suggesting that trait anger is a risk factor for PTSD symptoms, but that PTSD symptoms are also associated with an increase of state anger. Increased anger is important not only because of the impact it has on individual distress and physical health, but also because of its potential public health impact.
Does prior psychological health influence recall of military experiences? a prospective study
Authors: Wilson Jennifer , Jones Margaret , Hull Lisa , Hotopf Matthew , Wessely Simon , Rona Roberto J. 
Published: August 2008

AbstractIn a prospective study, we evaluated pre‐ and postdeployment psychological health on recall of risk factors to assess recall bias. Measures of the General Health Questionnaire (GHQ), PTSD Checklist (PCL), and symptom clusters from the PCL were obtained from 681 UK military personnel along with information on traumatic and protective risk factors. Postdeployment psychological health was more important in explaining recall of traumatic experiences than predeployment psychological health. Predeployment intrusive cluster scores were highly associated with traumatic exposures. Postdeployment, but not predeployment GHQ showed small effects for most risk factors. With the exception of intrusive thoughts, there is insufficient evidence to suggest predeployment psychological status would be useful in correcting for recall bias in subsequent cross‐sectional studies.
Patient reported and anatomical outcomes after surgery for pelvic organ prolapse
Authors: El‐Azab Ahmed S. , Abd‐Elsayed Alaa A. , Imam Hala M.K. 
Published: August 2008

AbstractAimPrimary aim was to modify Pelvic Floor Distress Inventory (PFDI) and Pelvic Floor Impact Questionnaire (PFIQ) to assess pelvic organ prolapse (POP) in Arabic Muslim women. Secondary aim was to compare functional and anatomical outcomes of POP repair.MethodsQuestionnaire. A characteristic (prayer) was added to PFIQ. Linguistic validation of questionnaires was then done. Twenty cases were enrolled in a pilot study to test internal consistency and reliability. Subsequent study. Prospective study included women with symptomatic POP ≥ stage II. History, examination by POP‐Q, and administration of PFDI and PFIQ, were done before and 6 months after surgery.ResultsQuestionnaire. Internal consistency of added question was good (Cronbach α = 0.78). Test–retest reliability of individual PFIQ items was variable. Subsequent Study. Between September 2004 and February 2007, 78 consecutive women were included. Cystocele, rectocele, and no site predominated in 74.4%, 17.9% and 7.7% of cases, respectively. Preoperatively 19.2%, 15.4% and 47.4% reported stress, urge, and mixed incontinence, respectively. Overall and individual urinary symptoms scores improved significantly after surgery. There were significant improvements in individual symptoms of constipation, splint to defecate and losing not well formed stools. Low self‐esteem was most negative impact of prolapse on quality of life (QoL) followed by prayer. After surgery 90% of subjects had anatomical cure. After surgery, QoL issues are significantly related to anatomic location of prolapse as determined by POP‐Q.ConclusionsModified PFIQ and PFDI are suitable to assess POP among Muslim women. Postoperatively, many prolapse‐related symptoms and QoL significantly improve after surgery on the short term with an anatomic cure rate of 90%. Neurourol. Urodynam. 28:219–224, 2009. © 2008 Wiley‐Liss, Inc.
Impact of irradiation‐induced point defects on electronically and ionically induced magnetic relaxation mechanisms in titano‐magnetites
Authors: Walz F. , Brabers V. A. M. , Kronmüller H. 
Published: August 2008

AbstractThis report deals with the analysis of point‐defect‐induced magnetic after‐effect (MAE) processes occurring in as‐grown, single‐crystalline titano‐magnetite (Fe2.8–D Ti0.2O4), containing B‐site vacancies (D < 0.005). In a foregoing experiment, these processes, situated near 450 K, 200 K and 65 K, have been completely recovered in the course of systematic annealing up to Ta ≤ 1200 K. Analysis of respective annealing kinetics suggested to associate them with vacancy‐ (450 K) and interstitial‐based (200 K) defect reorientations, including modified electron hopping (65 K). The present study was performed in order to check the previously developed relaxation model by low‐temperature (80 K) electron (e–) irradiation of the prerecovered crystal and investigating if thereby the point‐defect relaxations of the initial, as‐grown, state could be reconstituted. MAE analyses, based on systematic sample annealing in the temperature range 80 K ≤ Ta ≤ 1200 K prove, indeed, radiation‐induced reproduction of related processes. Partial modifications of respective process genealogies may be conveniently assigned to the alternative techniques of defect induction, i.e. high‐temperature crystal growth in thermal equilibrium or out‐of‐equilibrium, low‐temperature e–‐irradiation. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Photoconductivity and thermally stimulated current in CaGa2S4 single crystals doped with Eu2+ and Ce3+
Authors: Hidaka Chiharu , Hiraguri Kazuma , Takizawa Takeo 
Published: August 2008

AbstractPhotoconductivity (PC) measurements are carried out on single crystals of CaGa2S4 doped with Ce3+ and Eu2+ at room temperature and at about 30 K. Low temperature PC spectra can only be measured for Ce doped samples but not for Eu ones owing to too high resistivity. Based on the data obtained, the energy level scheme of Ce3+ ions is discussed in reference to the optical band edge.Single crystals of CaGa2S4 are grown by codoping Ce3+ with Na+ ions to observe the charge compensation effect expected to occur under the substitution of Ca2+ ions by Ce3+ ions. Their electrical resistivity is reduced about two orders in magnitude from ca. 1013 Ω cm to ca. 1011 Ω cm without much change in PC spectra, suggesting a mere decrease in scattering centers for carriers. From the variation in DC resistivity with time, it is expected that many carrier traps may exist in the compounds. To clarify those trap levels the thermally stimulated current (TSC) is measured using samples with different Ce3+ concentrations. From the analysis of TSC spectra, 6 traps with different depths have been retrieved. We have also found traps which may have repelling potential barriers. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Surface characterisation of silicon substrates seeded with diamond nanoparticles under UHV annealing
Authors: Arnault J. C. , Saada S. , Williams O. A. , Haenen K. , Bergonzo P. , Nesladek M. , Polini R. , Osawa E. 
Published: August 2008

AbstractThe thermal stability of Ultra Dispersed Diamond on silicon surfaces has been investigated. Samples have been annealed under Ultra‐High Vacuum conditions. The evolution of the carbon binding states at the surface has been monitored sequentially by XPS and XEELS. After annealing at 1173 K, sp3 seeds present initially have been significantly modified. Contrary to lower temperature, no diamond has been detected either by XPS or by FEG‐SEM after a short growth step. XPS spectra indicate the formation of silicon carbide. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Incremental modified pushover analysis
Authors: Azimi Hossein , Galal Khaled , Pekau Oskar A. 
Published: August 2008

AbstractThe recently developed Incremental Dynamic Analysis (IDA) requires nonlinear time history analyses at different levels of intensity of an ensemble of ground motions, which is time‐consuming due to the high computational efforts involved. In the current study, a simplified method named as Incremental Modified Pushover (IMP) is developed and evaluated. In this method, the response of the structure is obtained using one pushover analysis at any specified level of ground motion intensity. The associated higher mode effects are explicitly considered when determining target roof displacement and lateral load pattern. In the bilinear idealization of the pushover curves, a new approach has been used. Moment resisting steel frames with 4, 8, 12 and 16 stories, as well as their corresponding soft‐story models are used for verifying the proposed method. The studied frames were subjected to seventeen different scaled earthquake ground motions. The results of the presented method, IMP, are verified in terms of maximum roof displacement, maximum inter‐story drift and maximum plastic hinge rotation at different ground motion intensities. The results show that the IMP method gives higher response values compared with IDA, which can be viewed as being more conservative. Copyright © 2008 John Wiley & Sons, Ltd.
Leisure time physical activity during pregnancy and preterm birth in Brazil
Authors: Domingues Marlos R. , Barros Aluísio J. , Matijasevich Alicia 
Published: August 2008

AbstractObjectiveTo investigate the relationship between leisure time physical activity (LTPA) during pregnancy and preterm birth.MethodsA cross‐sectional, population‐based study evaluated LTPA during pregnancy in 4147 mothers using data from the 2004 Pelotas Birth Cohort Study. Gestational age was determined by last menstrual period, or when not available, by ultrasound or the Dubowitz method. Type of LTPA, length of usual session, and frequency were determined for each trimester.ResultsA total of 14.6% of all births were considered preterm. Only 13.3% of women reported engaging in LTPA during pregnancy. After adjusting for confounders, LTPA in all 3 trimesters (prevalence ratio [PR] 0.55; 95% confidence interval [CI] 0.32–0.96), LTPA in the third trimester (PR 0.50; 95% CI 0.31–0.80), and minimum LTPA (≥ 90 min/week) in the third trimester (PR 0.58; 95% CI 0.34–0.98) showed a protective association with preterm birth in the adjusted analysis.ConclusionLTPA, especially throughout pregnancy and in the third trimester, was associated with a lower chance of preterm birth.
Collagen type 3 alpha 1 polymorphism and risk of pelvic organ prolapse
Authors: Chen Huey‐Yi , Chung Ya‐Wen , Lin Wei‐Yong , Wang Jiunn‐Chin , Tsai Fuu‐Jen , Tsai Chang‐Hai 
Published: August 2008

AbstractObjectiveTo investigate whether pelvic organ prolapse (POP) is associated with collagen 3 alpha 1 (COL3A1) polymorphisms and other factors.MethodsA case‐control association study was conducted with 84 women affected with POP and 147 controls. The genotypes of nucleotides COL3A1 rs1800255 and COL3A1 rs1801184 polymorphisms were ascertained by polymerase chain reaction and restriction fragment length polymorphism analysis.ResultsThe distribution of the COL3A1 rs1800255 genotypes was significantly different among affected women and controls. Older age and incidence of COL3A1 rs1800255 genotype AA were significantly associated with risk of POP.ConclusionThere may be an association between COL3A1 genotype and risk of POP.
Progesterone receptor gene polymorphisms are not associated with preterm birth in a Hispanic population
Authors: Diaz‐Cueto Laura , Dominguez‐Lopez Pablo , Cantillo‐Cabarcas Julio , Perez‐Figueroa Gloria , Arechavaleta‐Velasco Miguel , Arechavaleta‐Velasco Fabian 
Published: August 2008

AbstractObjectiveTo determine whether increased frequency of mutant alleles of the progesterone receptor gene (PGR) was associated with preterm birth in a population of Hispanic women.MethodsPlacental DNA from 64 patients who had preterm births and 54 control patients was genotyped for 4 progesterone receptor gene polymorphisms by polymerase chain reaction (PCR) restriction fragment length polymorphism. The test and t test were used to calculate statistical significance. Linkage disequilibrium was calculated using the Linkage Disequilibrium Analyzer program.ResultsThe genotypic frequencies of the 4 polymorphisms were not significantly different between the study and control groups. In addition, there was complete linkage disequilibrium between V660L, H770H, and PROGINS polymorphisms, but not with + 331G/A polymorphism.ConclusionsThe present study suggests that polymorphisms in the progesterone receptor gene are unlikely to be associated with an increased risk of preterm birth in a Hispanic population.
Clinical significance of micrometastases detection in lymph nodes from head and neck squamous cell carcinoma
Authors: Xu Yanan , Lefèvre Marine , Périé Sophie , Tao Lei , Callard Patrice , Bernaudin Jean‐François , Guily Jean Lacau St 
Published: August 2008

OBJECTIVEStudy the clinical relevance of micrometastases in head and neck squamous cell carcinoma (HNSCC).METHODSWe reviewed the outcome of 31 patients who underwent neck dissection for HNSCC with lymph node analysis by cytokeratin 19 real‐time Taqman polymerase chain reaction (CK19RT‐PCR) for detection of micrometastasis. Fifteen patients were N+ on histopathology (group 1) and 16 were N‐; nine of these 16 patients were CK19RT‐PCR positive (group 2), whereas seven were negative (group 3). Local and neck recurrences, metastases, and other tumour sites were recorded during follow‐up.RESULTSFive patients in group 1, eight patients in group 2, and one patient in group 3 experienced a tumor‐related event. N‐patients in groups 2 and 3 had a different outcome (P < 0.01).CONCLUSIONIt is suggested that CK19RTPCR detection of micrometastasis in lymph nodes could be of significant prognostic value in HNSCC, because more aggressive treatment could be indicated in these patients.
The administration of IL‐12/GM‐CSF and Ig‐4‐1BB ligand markedly decreases murine floor of mouth squamous cell cancer
Authors: Adappa Nithin D. , Sung Chi‐Kwang , Choi Bryan , Huang Tian‐Gui , Genden Eric M. , Shin Edward J. 
Published: August 2008

OBJECTIVETo assess immune‐based gene therapy in a murine floor of mouth (FOM) squamous cell carcinoma (SCC) model.STUDY DESIGNIn vitro and in vivo testing of immune therapy for SCC.METHODSMultiple SCC lines were infected by using advRSV‐interleukin‐12 (IL‐12) and advCMV‐interleukin‐12/granulocyte macrophage colony‐stimulating factor (IL‐12/GM‐CSF) and monitored for production of IL‐12 and GM‐CSF. Intratumoral injections of viral vectors were administered with systemic Ig‐4‐1BB ligand in an orthotopic murine FOM SCC model and followed for tumor size and survival.RESULTSIn vitro, all cell lines produced substantial levels of IL‐12 and GM‐CSF. In vivo, tumors treated with advCMV‐IL‐12/GM‐CSF and Ig‐4‐1BBL showed a striking reduction in tumor volume (vs control P < 0.0001) and improved median survival (38 days vs 19 days for control, P < 0.0001).CONCLUSIONCombination immune‐based therapies effectively improve survival in mice bearing FOM SCC over single‐modality therapy.
Prognostic factors of unknown primary head and neck squamous cell carcinoma
Authors: Huang Chun‐Chi , Tseng Fen‐Yu , Yeh Te‐Huei , Wen Yu‐Hsuan , Hsu Chuang‐Jen , Ko Jeng‐Yuh , Lou Pei‐Jen , Chen Yuh‐Shyang 
Published: August 2008

OBJECTIVETo evaluate the prognostic factors of unknown primary head and neck squamous cell carcinoma (HNSCC).STUDY DESIGNRetrospective study.SUBJECTSPatients with unknown primary HNSCC from 1980 to 2000 were included.RESULTSForty‐eight patients, predominantly male and with a mean age of 63.3 ± 11.6 years, were recruited. The median survival time (MST) was 44 months. The overall survival rate was 60.4 percent at three years and 39.6 percent at five years. Forty‐two patients receiving intervention regimens had a MST of 45 months, while six patients receiving palliative therapy had a MST of 8.5 months (log rank test, P = 0.016). With multivariate Cox regression analysis, age (per year), higher nodal stage (N3 vs N1 or N2), and treatment (operation vs nonoperation) had a hazard ratio of 1.081 (P < 0.0001), 5.852 (P = 0.010), and 0.4 (P = 0.042), respectively.CONCLUSIONOlder age, higher nodal stage, and palliative treatment indicated poor prognosis. Survival time might be prolonged if surgical treatment is tolerable.
A systematic review of the use of intranasal steroids in the treatment of chronic rhinosinusitis
Authors: Joe Stephanie A. , Thambi Rakhi , Huang Jie 
Published: August 2008

OBJECTIVETo determine if intranasal steroids (INS) are useful in the management of chronic rhinosinusitis without polyps and chronic rhinosinusitis (CRS) with polyps.DATA SOURCESStudies for inclusion were searched using Medline, EMBASE, Cochrane databases, and references of included studies.REVIEW METHODSInitial screening of article titles and abstracts obtained from the literature search was performed independently by two reviewers (SAJ and RT) based on the research protocol criteria. These articles then underwent a second‐stage review. Each article was read in detail and discussed by the two reviewers before inclusion in the study.RESULTSThe review yielded 13 studies regarding the treatment of sinonasal polyps with intranasal steroids. Six of these could be included in the meta‐analysis. The outcome measure used for meta‐analysis was change in polyp size from baseline compared between the treatment and control groups. Results from both conservative and optimistic selection of treatment effect are positive, providing significant improvement in polyp size in the treatment group as compared to controls. In the conservative estimate, the mean improvement in polyp size score between the treatment and placebo group is 0.43 with a 95% CI of [0.25, 0.61]. Of those treatment groups with the largest improvement, the mean improvement in polyp size score can go as high as 0.63 with a 95% CI of [0.43, 0.82].CONCLUSIONIntranasal steroids are beneficial in the treatment of chronic rhinosinusitis with sinonasal polyps. Further studies looking at the use of INS in the treatment of CRS without polyps are warranted.
Actinomycosis of the paranasal sinus
Authors: Woo Hyun‐Jae , Chang Hoon Bae , Song Si‐Youn , Choi Yun Seok , Kim Yong‐Dae 
Published: August 2008

OBJECTIVETo report clinical characteristics and treatment outcomes of actinomycosis of the paranasal sinus.STUDY DESIGNRetrospective review.SUBJECTS AND METHODSThe medical records of six patients with actinomycosis of the paranasal sinus between 1998 and 2006 were analyzed.RESULTSThere were no immunocompromised patients and all lesions were unilateral. Only one patient had a history of an oroantral fistula due to facial trauma. On CT scan, all patients had unilateral opacification of the maxillary sinus with focal calcified densities. All cases underwent endoscopic sinus surgery followed by relatively short‐term antibiotic administration, and there was no recurrence.CONCLUSIONSChronic unilateral maxillary sinusitis, a calcified density in the involved sinus on radiological studies, and unresponsiveness to antibiotics are characteristics of actinomycotic sinusitis. Surgical removal of the involved tissues and the restoration of sinus ventilation seem to be important factors for treating the disease.
Residual hearing preservation after cochlear implantation: Comparison between straight and perimodiolar implants
Authors: Soda‐Merhy Antonio , Gonzalez‐Valenzuela Leonardo , Tirado‐Gutierrez Carmen 
Published: August 2008

ObjectiveInvestigate whether perimodiolar cochlear implants provide a better preservation of residual hearing than straight implants.Study Design and SettingLongitudinal, observational, and comparative study in tertiary center in Mexico City. Forty‐eight patients who underwent cochlear implant surgery were included and were divided into two groups depending on whether they received a straight or a perimodiolar implant. The residual hearing of the operated ear was measured audiometrically before and after surgery. Variables analyzed were pure‐tone average threshold at 125, 250, and 500 Hz and residual hearing at frequencies from 125 to 8000 Hz. Residual hearing was considered as preserved when audiometric changes were less than 10 dB HL in each variable.ResultsNo statistically significant difference was found in the preservation of residual hearing between the two groups or between individual devices (P > 0.05 in all variables).ConclusionStraight and perimodiolar cochlear implants seem to preserve residual hearing at similar rates across frequencies.
Randomized controlled studies and the treatment of middle‐ear effusions and tonsillar pharyngitis: How random are the studies and what are their limitations?
Authors: Ruben Robert J. 
Published: August 2008

ObjectiveTo determine the applicability and external validity of randomized control studies (RCTs) in the light of patient susceptibilities and vulnerabilities to the sequelae of otitis media with effusion (OME) and tonsillar pharyngitis (T&A) and the composition of their cohorts.Study DesignRCTs for OME and T&A were analyzed to determine which intrinsic and extrinsic susceptibilities to the otolaryngic disease and its sequelae were included or excluded and the composition of the cohort.MethodsA Medline and a Science Direct search were performed for all RCTs concerning OME and T&A through 2007. The articles selected to be included in this study are the OME RCTs that reported language and/or hearing outcomes and the T&A RCT studies in which the outcome measure was infection, alleviation of airway obstruction, and/or quality of life. These were analyzed for their inclusion or exclusion of intrinsic and extrinsic susceptibilities to the otolaryngic disease and their sequelae and the composition of the cohort. The pertinent otolaryngologic literature was assessed to determine applicable risk factors.ResultsThe analysis of the inclusion or exclusion of risk factors showed that for OME 0 percent were included and 16 percent were excluded, and there were no data for 84 percent. The T&A findings were similar in that 1 percent of risk factors were included, 8 percent excluded, and there were no data for 92 percent. Both the OME and the T&A cohorts data were similar in that approximately half of the suitable candidates completed the study; 25 percent of the OME and 13 percent of the T&A enrolled subjects were either withdrawn or placed into a different experimental group. On the average, with data available, it took 4.6 years to recruit the OME sample and 5.5 years to recruit the T&A sample.ConclusionThe results of RCTs for these conditions are only applicable to narrowly defined and highly circumscribed populations. They cannot be generalized to the entire patient population because of their limited external validity. Future RCT protocols should be designed to control for the intrinsic and extrinsic susceptibilities that result in a propensity to acquire the disease and/or an exacerbation of the disease's sequelae. These studies would determine the most effective strategies for preventing disorders and/or their deleterious sequelae.