bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Music on Ambulatory Surgery Patients' Preoperative Anxiety
Authors: Augustin Penny , Hains Anthony A. 
Published: August 2006

ABSTRACTThe authors investigated music as a method to reduce ambulatory surgery patients' preoperative anxiety. They assigned 42 patients to either an experimental or a control group and compared the patients' vital signs and self‐reports of anxiety, which were measured using the state portion of the State‐Trait Anxiety Inventory. The study results indicate that music can be more beneficial than preoperative instruction alone in reducing ambulatory surgery patients' anxiety. Patients who listened to their choice of music before surgery in addition to receiving preoperative instruction had significantly lower heart rates than patients in the control group who received only preoperative instruction. Differences in experimental and control group patients' blood pressure measurements and respiratory rates approached significance. The authors suggest that perioperative nurses offer music as a viable option to reduce anxiety in ambulatory surgery patients who believe music is a method of relaxation.AORN J63 (April 1996) 750–758.
An Interactionist's Approach to Perioperative Nursing
Authors: Rosenthal Barbara C. 
Published: August 2006

ABSTRACTMost nurse‐patient interactions in the OR are of short duration; therefore, formulating appropriate care plans for accurate patient assessments is paramount. Observations of a patient's behavior without a deliberative exploration to disclose the behavioral meanings can lead to erroneous nursing diagnoses and interventions. A perioperative nurse who uses the theoretical approach developed by Ida Jean Orlando, RN, MA, will be able to identify the patient's covert needs, thereby providing timely, therapeutic nursing interventions. The article presents a perioperative clinical situation analyzed through Orlando's Interactional framework, demonstrating the theory's beneficial impact on patient outcomes. AORN J 64 (Aug 1996) 254–260.
Interviewing Techniques for Hiring Quality Employees in the OR
Authors: Timmons Linda J. 
Published: August 2006

ABSTRACTToday's OR requires high caliber employees to provide quality patient care and excellent service to their medical staff members. As such, there Is clearly a need for some mode of identifying the appropriate individuals to fill specific vacant positions. A recent survey was conducted of OR directors and managers in Miami, Fla. The purpose of the survey was to identify exactly what types of education and/or training directors and managers had acquired with respect to interviewing techniques and to determine whether there was any consistency in their interview processes. Based on the surveys' findings it was found that there is a lack of relevant training amongst those directors and managers who conduct interviews. This training could include the implementation of standardized interview questions (for candidates of specific job descriptions) for use on a consistent basis as well as a process of evaluation for the interview. AORN J 67 (Jan 1998) 222‐228.
Bilateral Lung Volume Reduction Surgery
Authors: Graling Paula R. , Hetrick Vivian L. , Kiernan Paul D. 
Published: August 2006

ABSTRACTA new surgical approach, bilateral lung volume reduction surgery (LVRS), offers hope for select patients with chronic pulmonary emphysema (CPE). Bilateral LVRS procedures involve excision of emphysematous alveoli, which results in a 20% to 30% reduction in the volume of each lung. The goal of LVRS is to improve the respiratory mechanics of patients with CPE by reexpanding functional lung tissue compressed by overdistended emphysematous alveoli, restoring diaphragmatic mobility, and improving the bellows function of the chest wall structures. Patients undergoing bilateral LVRS procedures experience relief from chronic dyspnea and may note improved pulmonary functions and better quality of life. AORN J 63 (Feb 1996) 389–404.
Recovery from Laparoscopic Cholecystectomy Procedures
Authors: Cason Carolyn L. , Seidel Saundra L. , Bushmiaer Marty 
Published: August 2006

ABSTRACTThe authors studied the postoperative experiences of 53 patients who had uncomplicated laparoscopic cholecystectomy procedures. Patients rated their pain, nausea, vomiting, and fatigue before surgery, before discharge, and on postoperative days one, two, three, four, and seven. The majority of patients reported more difficult and painful and slower recoveries than they expected or that they believed were indicated in the education materials provided to prepare them for surgery. The experiences of the patients in this study clearly indicate a need to modify preoperative preparatory education materials. AORN J 63 (June 1996) 1099–1116.
Right Thoracotomy Approach to Mitral Valve Surgical Procedures
Authors: Coulson Alan S. , Quarnstrom Judy A. , Holmes Katrina , Henry Joann 
Published: August 2006

ABSTRACTThe right thoracotomy approach to mitral valve surgical procedures allows surgeons to achieve excellent, rapid exposures of mitral annuli; facilitates the excision of diseased mitral valves; avoids injury to previously placed coronary artery bypass grafts; and aids surgeons with the insertion of valve prostheses. This approach is especially appropriate for patients with anatomic deviations (eg, deep chest cavities, counterclockwise rotations of the heart) and hostile mediastina (ie, previously opened mediastina with severe adhesions around the heart and posterior side of the sternum). This article discusses mitral valve disease, compares the right thoracotomy approach to median sternotomy, describes perioperative nursing care of patients undergoing mitral valve surgical procedures, and presents a case study. AORN J 65 (Feb 1997) 347–364.
The Significance and Application of Informed Consent
Authors: Brazell Nancy E. 
Published: August 2006

ABSTRACTBringing well‐informed patients to the OR is a challenge for all who participate in surgical patients' care. Although the issue of informed consent has been around for a long time, it was not until the latter half of the twentieth century that health care professionals and patients began to focus on informed consent as a central concern in health care. This article explains the roots of informed consent, the path it has traveled, and the importance that health care professionals, especially perioperative nurses, play in ensuring that patients are fully informed about their impending procedures. AORN J 65 (Feb 1997) 377–386.
Building Perioperative Nursing Research Teams—Part I
Authors: Csokasy Judith A. 
Published: August 2006

ABSTRACTPerioperative nurses can use nursing research to acquire skills and knowledge to formulate independent judgments, make critical decisions, and become nurse scholars. This article, which is the first in a two‐part series, describes the use of the model of experiential learning developed by David A. Kolb, PhD, to facilitate a team approach to perioperative nursing research. The second article in the series will focus on constraints and enablers to conducting and using nursing research in perioperative care settings and will provide suggestions for perioperative nurse managers to facilitate clinical research. AORN J 65 (Feb 1997) 396‐401.
Triple Arthrodesis
Authors: Schramm Carol A. , Hein Suzanne C. , Cooper Paul S. 
Published: August 2006

ABSTRACTTriple arthrodesis is the surgical fusion of the calcaneocuboid, talonavicular, and talocalcaneal joints of the foot. This is a palliative surgical procedure used to treat many painful hindfoot disorders (eg, clubfoot deformity, arthritis, Charcot's joint disease). Patient benefits include pain relief and improvement in foot function. Several anesthesia options are available for intraoperative and postoperative pain management. Perioperative nurses should be knowledgeable about foot anatomy, the sequence of surgical events, and possible postoperative complications from triple arthrodesis. A systems approach to patient care throughout the perioperative phase can ensure optimal patient outcomes.
Collagen Injection Therapy for Type III Stress Urinary Incontinence
Authors: Bartholomew Barbara , Grimalid Thomas 
Published: August 2006

ABSTRACTUrinary incontinence is a distressing, demoralizing, costly condition that affects 10% to 25% of women and up to 5% of men between the ages of 15 and 60 years. One common type of urinary incontinence is stress urinary incontinence (SUI), which is the involuntary loss of urine during physical activities that increase intraabdominal pressure. Many individuals with SUI have intrinsic sphincter deficiency. Until recently, treatment for intrinsic sphincter deficiency involved open surgical procedures and lengthy recovery periods. Patients now have the option of undergoing a less‐invasive treatment: collagen injections into their bladder necks and proximal urethras. Perioperative nurses can enhance the success of collagen injection therapy by understanding the psychosocial needs of patients with SUI, the patient selection criteria and diagnostic tests required for this new treatment approach, and the nursing role in collagen injection procedures.
A Western OR Delegation to the People's Republic of China
Authors: Spry Cynthia C. 
Published: August 2006

ABSTRACTNursing in the People's Republic of China (PRC) is beginning to revitalize after decades of the repression and obliteration of nursing education programs under the rule of Mao Tse‐tung. A delegation of American, Australian, and Canadian perioperative nurses traveled to the PRC for a series of professional exchanges with Chinese OR nurse colleagues. The exchange was an affirmation of the common commitment to caring that all nurses share. AORN J 63 (March 1996) 525–532.
State–Society Relations in Burma and the Philippines
Authors: Hlaing Kyaw Yin 
Published: August 2006

Burma at the turn of the twenty-first century Edited by MONIQUE SKIDMORE
Honolulu: University of Hawaii Press, 2005. Pp. vii, 304. Illustrations, Maps,
Bibliography, Index.State and society in the Philippines
By PATRICIO ABINALES and DONNA AMOROSO
Lanham: Rowman and Littlefield Publishers, Inc., 2005. Pp. xxxiv, 353. Illustrations,
Bibliography, Index.
Beyond Knowledge to Wisdom in International Business Strategy
Authors: McKenna Bernard , Rooney David , Liesch Peter W. 
Published: August 2006

Abstract
A wisdom approach is advanced as a means of breaking the mimesis of institutional isomorphism that is observed both in the practice and scholarship of orthodox business management. Nine principles of wisdom derived from the Aristotelian tradition and contemporary psychological research are provided. These are then tested in an international business case study. This analysis supports the case that, while rational judgment is necessary, wise management also requires a capacity for counter‐intuition, vision, and humanity. It also shows that wisdom in management must ultimately be practical. When practised by wise managers, such wisdom can opportunistically circumvent the discursive limitations imposed by current orthodoxy in the turbulent, ephemeral conditions of international business and its management.
Bio3d: an R package for the comparative analysis of protein structures
Authors: Grant Barry J. , Rodrigues Ana P. C. , ElSawy Karim M. , McCammon J. Andrew , Caves Leo S. D. 
Published: August 2006

Abstract
Summary: An automated procedure for the analysis of homologous protein structures has been developed. The method facilitates the characterization of internal conformational differences and inter-conformer relationships and provides a framework for the analysis of protein structural evolution. The method is implemented in bio3d, an R package for the exploratory analysis of structure and sequence data.
Availability: The bio3d package is distributed with full source code as a platform-independent R package under a GPL2 license from:
Contact: bgrant@mccammon.ucsd.edu
Model-based boosting in high dimensions
Authors: Hothorn Torsten , Bühlmann Peter 
Published: August 2006

Abstract
Summary: The R add-on package mboost implements functional gradient descent algorithms (boosting) for optimizing general loss functions utilizing componentwise least squares, either of parametric linear form or smoothing splines, or regression trees as base learners for fitting generalized linear, additive and interaction models to potentially high-dimensional data.
Availability: Package mboost is available from the Comprehensive R Archive Network () under the terms of the General Public Licence (GPL).
Contact: Torsten.Hothorn@R-project.org
The folding mechanism of collagen‐like model peptides explored through detailed molecular simulations
Authors: Stultz Collin M. 
Published: August 2006

AbstractCollagen has a unique folding mechanism that begins with the formation of a triple‐helical structure near its C terminus followed by propagation of this structure to the N terminus. To elucidate factors that affect the folding of collagen, we explored the folding pathway of collagen‐like model peptides using detailed molecular simulations with explicit solvent. Using biased molecular dynamics we examined the latter stages of folding of a peptide model of native collagen, (Pro‐Hyp‐Gly)10, and a peptide that models a Gly → Ser mutation found in several forms of osteogenesis imperfecta, (Pro‐Hyp‐Gly)3‐Pro‐Hyp‐Ser‐(Pro‐Hyp‐Gly)6. Starting from an unfolded state that contains a C‐terminal nucleated trimer, (Pro‐Hyp‐Gly)10 folds to a structure where two of the three chains associate through water‐mediated hydrogen bonds and the third is relatively separated from this dimer. Calculated free‐energy profiles for folding from this intermediate to the final triple‐helical structure suggest that further folding occurs at a rate of approximately one Pro‐Hyp‐Gly triplet per msec. In contrast, after 6 nsec of biased dynamics, the region N‐terminal to the Ser residue in (Pro‐Hyp‐Gly)3‐Pro‐Hyp‐Ser‐(Pro‐Hyp‐Gly)6 folds to a structure where the three chains form close contacts near the N terminus, away from the mutation site. Further folding to an ideal triple‐helical structure at the site of the mutation is unfavorable as the free energy of a triple‐helical conformation at this position is more than 20 kcal/mol higher than that of a structure with unassociated chains. These data provide insights into the folding pathway of native collagen and the events underlying the formation of misfolded structures.
Identification of an alcohol binding site in the first cysteine‐rich domain of protein kinase C δ
Authors: Das Joydip , Zhou Xiaojuan , Miller Keith W. 
Published: August 2006

AbstractProtein kinase C (PKC) is an important signal transduction protein whose cysteine‐rich regulatory domain C1 has been proposed to interact with general anesthetics in both of its diacylglycerol/phorbol ester–binding subdomains, the tandem repeats C1A and C1B. Previously, we identified an allosteric binding site on one of the two cysteine‐rich domains, PKCδ C1B. To test the hypothesis that there is an additional anesthetic site on the other cysteine‐rich subdomain, C1A, we subcloned, expressed in Escherichia coli, purified, and characterized mouse PKCδ C1A. Octanol and butanol both quenched the intrinsic fluorescence of PKCδ C1A in a saturable manner, suggesting the presence of a binding site. To locate this site, PKCδ C1A was photolabeled with three diazirine‐containing alkanols, 3‐azioctanol, 7‐azioctanol, and 3‐azibutanol. Mass spectrometry revealed that at low concentrations all three photoincorporated into PKCδ C1A with a stoichiometry of 1:1 in the labeled fraction, but higher stoichiometries occurred at higher concentrations, particularly with azibutanol. Photocomplexes of PKCδ C1A with azioctanols were separated from the unlabeled protein by HPLC, reduced, alkylated, digested with trypsin, and sequenced by mass spectrometry. All the azioctanols photolabeled PKCδ C1A at residue Tyr‐29, corresponding to Tyr‐187 of the full‐length PKCδ, and at a neighboring residue, Lys‐40, suggesting there is an alcohol site in this vicinity. In addition, Glu‐2 was photolabeled more efficiently by 3‐azibutanol than by the azioctanols, suggesting the existence of a second, smaller site.
The structure of GDP‐4‐keto‐6‐deoxy‐d‐mannose‐3‐dehydratase: A unique coenzyme B6‐dependent enzyme
Authors: Cook Paul D. , Thoden James B. , Holden Hazel M. 
Published: August 2006

Abstractl‐Colitose is a 3,6‐dideoxysugar found in the O‐antigens of some Gram‐negative bacteria such as Escherichia coli and in marine bacteria such as Pseudoalteromonas tetraodonis. The focus of this investigation, GDP‐4‐keto‐6‐deoxy‐d‐mannose‐3‐dehydratase, catalyzes the third step in colitose production, which is the removal of the hydroxyl group at C3′ of GDP‐4‐keto‐6‐deoxymannose. It is an especially intriguing PLP‐dependent enzyme in that it acts as both a transaminase and a dehydratase. Here we present the first X‐ray structure of this enzyme isolated from E. coli Strain 5a, type O55:H7. The two subunits of the protein form a tight dimer with a buried surface area of ∼5000 Å2. This is a characteristic feature of the aspartate aminotransferase superfamily. Although the PLP‐binding pocket is formed primarily by one subunit, there is a loop, delineated by Phe 240 to Glu 253 in the second subunit, that completes the active site architecture. The hydrated form of PLP was observed in one of the enzyme/cofactor complexes described here. Amino acid residues involved in anchoring the cofactor to the protein include Gly 56, Ser 57, Asp 159, Glu 162, and Ser 183 from one subunit and Asn 248 from the second monomer. In the second enzyme/cofactor complex reported, a glutamate ketimine intermediate was found trapped in the active site. Taken together, these two structures, along with previously reported biochemical data, support the role of His 188 as the active site base required for catalysis.
Polymorphism at the β3‐adrenergic receptor (ADRB3) locus of Merino sheep and its association with lamb mortality
Authors: Forrest R. H. , Hickford J. G. H. , Wynyard J. , Merrick N. , Hogan A. , Frampton C. 
Published: August 2006

Summary β
3‐adrenergic receptors are predominantly found on the surface of adipocytes and are major mediators of the lipolytic and thermogenic effects of high catecholamine concentrations. Recently, variation in the ovine β3‐adrenergic receptor (ADRB3) gene has been reported to be associated with lamb survival. In this study, polymerase chain reaction‐single strand conformational polymorphism analysis of part of the ADRB3 intron was used to genotype 4488 Merino lambs born at 10 farms throughout the South Island of New Zealand. Univariate and multivariate odds ratios for each allele revealed a significant association of the E allele with cdd survival and of the D allele with mortality. This variation at the ADRB3 locus may assist in the genetic selection for survival in Merino sheep.
Population pharmacokinetics of darbepoetin alfa in healthy subjects
Authors: Agoram Balaji , Sutjandra Liviawati , Sullivan John T. 
Published: August 2006

AimTo develop and evaluate a population pharmacokinetic (PK) model of the long‐acting erythropoiesis‐stimulating protein, darbepoetin alfa in healthy subjects.MethodsPK profiles were obtained from 140 healthy subjects receiving single intravenous and/or single or multiple subcutaneous doses of darbepoetin alfa (0.75–8.0 µg kg−1, or either 80 or 500 µg). Data were analysed by a nonlinear mixed‐effects modelling approach using NONMEM software. Influential covariates were identified by covariate analysis emphasizing parameter estimates and their confidence intervals, rather than stepwise hypothesis testing. The model was evaluated by comparing simulated profiles (obtained using the covariate model) to the observed profiles in a test dataset.ResultsThe population PK model, including first‐order absorption, two‐compartment disposition and first‐order elimination, provided a good description of data. Modelling indicated that for a 70‐kg human, the observed nearly twofold disproportionate dose–exposure relationship at the 8.0 µg kg−1‐dose relative to the 0.75 µg kg−1‐dose may reflect changing relative bioavailability, which increased from ∼ 48% at 0.75 µg kg−1 to 78% at 8.0 µg kg−1. The covariate analysis showed that increasing body weight may be related to increasing clearance and central compartment volume, and that the absorption rate constant decreased with increasing age. The full covariate model performed adequately in a fixed‐effects prediction test against an external dataset.ConclusionThe developed population PK model describes the inter‐ and intraindividual variability in darbepoetin alfa PK. The model is a suitable tool for predicting the PK response of darbepoetin alfa using clinically untested dosing regimens.
Risk of hospitalization for angio‐oedema among users of newer COX‐2 selective inhibitors and other nonsteroidal anti‐inflammatory drugs
Authors: Downing Amy , Jacobsen Jacob , Sorensen Henrik T. , McLaughlin Joseph K. , Johnsen Soren P. 
Published: August 2006

What is already known about this subject• There is some evidence that the risk of cutaneous reactions is lower in patients taking newer cyclooxygenase (COX)‐2 selective inhibitors than in users of other nonsteroidal anti‐inflammatory drugs (NSAIDs).• However, the data are inconclusive and formal epidemiological evidence is lacking.What this study adds• This population‐based case–control study found no elevated risk for angio‐oedema amongst users of newer COX‐2 selective inhibitors, whilst users of other NSAIDS were shown to have an increased risk.• Our data support the hypothesis that newer COX‐2 selective inhibitors are safe in relation to angio‐oedema.• However, given other current health concerns related to these drugs, their use should continue to be carefully monitored.AimTo examine the risk of angio‐oedema among users of the newer cyclooxygenase (COX)‐2 selective inhibitors celecoxib and rofecoxib and other non‐aspirin nonsteroidal anti‐inflammatory drugs (NSAIDs) in a population‐based case–control study.MethodsCases of angio‐oedema were identified from hospital discharge registries from three Danish counties between 1 January 2000 and 31 December 2003 (n = 377) and 10 matched population controls per case were selected from the Civil Registration System (n = 3747). Data on newer COX‐2 selective inhibitor and other NSAID use (current and former) were obtained from prescription databases. Data on potential confounding factors were also collected. Conditional logistic regression was used to compute relative risks for angio‐oedema according to drug exposure.ResultsThe crude relative risks for the newer COX‐2 selective inhibitors were higher than those for other NSAIDs. After adjustment for confounding, the relative risk for current use of newer COX‐2 selective inhibitors was 0.96 [95% confidence interval (CI) 0.46, 2.03], whereas the risk for other NSAIDs was 1.77 (95% CI 1.23, 2.58).ConclusionOur data support the hypothesis that newer COX‐2 selective inhibitors are safe in relation to angio‐oedema. However, given other current health concerns related to these drugs, their use should continue to be carefully monitored.