bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation, Structural Characterization and Ligand Exchange Reactivity of Sterically Hindered 1,3‐Bis‐(4‐methyl‐2‐thiazolylimino)isoindolinatopalladium(II) Complexes
Authors: Bröring Martin , Kleeberg Christian 
Published: October 2007

AbstractTwo new palladium(II) complexes of sterically hindered 1,3‐bis‐(4‐methyl‐2‐thiazolylimino)isoindoline ligands [(4‐MeBTI)PdX] with X = OAc (4) and X = Cl (5) have been prepared from the free base H(4‐MeBTI) (3) and Pd(OAc)2 or PdCl2, respectively, in good yields. Both species reside as distinct mononuclear entities in the solid state, the latter as a chloroform solvate. The acetato derivative 4 is slowly transformed into the chlorido complex 5 by the action of chloroform or by chloride anions via a salt metathesis reaction. Mixed crystals containing both compounds can be obtained in which the molecules are situated in an isotypical arrangement with respect to 5 × CHCl3.
Oligonuclear Amide‐bridged Ferrocenes from N‐Fmoc Protected 1‐Amino‐1′‐fluorocarbonyl Ferrocene
Authors: Heinze Katja , Siebler Daniel 
Published: October 2007

AbstractOligoamides with ferrocenes in the backbone were prepared by stepwise coupling techniques using ferrocenoyl fluorides. The key building block is N‐Fmoc protected 1‐amino‐1′‐fluorocarbonyl ferrocene FmocNH–fn–COF (5). Stepwise coupling of 5 with amino ferrocene Fc–NH2 and (after deprotection) ferrocene carboxylic acid fluoride Fc–COF or 1‐(acetylamino)‐ferrocene‐1′‐carboxylic acid fluoride CH3C(O)NH–fc–COF yielded the dinuclear ferrocene Fc–NHC(O)–fn–NHFmoc (6) and the trinuclear ferrocenes Fc–NHC(O)–fn–NHC(O)–Fc (8) and Fc–NHC(O)–fn–NHC(O)–fn–NHC(O)CH3 (11), respectively. In solution 6 prefers a conformation with an intramolecular hydrogen bond while in the solid state intermolecular hydrogen bonds prevail. The electronic interaction of the ferrocene units in bi‐ and trinuclear ferrocenes with amide linkers has been assessed by electrochemical studies.
Crystal Structure and Properties of (H9O4)2[Mo2(S2)2X8] (X = Cl, Br)
Authors: Sokolov Maxim N. , Abramov Pavel A. , Peresypkina Eugenia V. , Virovets Alexander V. , Uvarov Nikolai F. , Gerasko Olga A. , Fedin Vladimir P. 
Published: October 2007

AbstractThe crystal structure of (H9O4)2[Mo2(S2)2Cl8] (1), obtained by treatment of MoS2Cl3(TeCl4)2 with hot concentrated HCl with subsequent crystallization upon cooling, was determined. The isostructural bromide (H9O4)2[Mo2(S2)2Br8] (2) was obtained in the same way. The proton conductivity of 1 and 2 was measured. Thermal decomposition of both compounds leads to amorphous MoS2 with a large specific surface (143 m2/g for MoS2, obtained from 1).
Organozinnoxometallate mit neuartigen Strukturen
Authors: Kondracka Małgorzata , Herntrich Tobias , Merzweiler Kurt 
Published: October 2007

AbstractOrganozinnoxometallate zeichnen sich durch eine große strukturelle Vielfalt aus, die von Koordinationspolymeren mit unterschiedlichen Netzwerktopologien bis zu Clustern und kleineren Molekülverbindungen reicht. In diesem Beitrag beschreiben wir einige unserer jüngsten Ergebnisse in der Synthese und der strukturellen Charakterisierung von Organozinnvandaten, ‐molybdaten und ‐wolframaten. Organozinnvandate sind durch die Umsetzung von Organozinnhalogeniden R3SnCl bzw. R2SnCl2 mit Vanadaten, wie z. B. NH4VO3 oder Na3VO4 zugänglich. Für die Synthese der Organozinnmolybdate und ‐wolframate ist die Umsetzung von R3SnCl mit (NR′4)2[M6O19] (M = Mo, W) in Gegenwart von (NR′4)OH geeignet.
Reaction of the Acyl(hydrido)cobalt(III) Complex with 2‐Propyn‐1‐ol
Authors: She Lei , Sun Hongjian , Li Xiaoyan 
Published: October 2007

AbstractAcyl(hydrido)cobalt(III) complexes mer‐[CoIII(O∩C=O)(H)(PMe3)3] (1 and 2) stabilized by 2‐acylphenolato‐chelating ligands and with the support of trimethylphosphine react with 2‐propyn‐1‐ol to generate inserting products of alkyne bond into Co‐H bond bearing bis‐chelating vinyl cobalt(III) complexes cis‐[CoIII(O∩C=O)(HO∩C=CH2)(PMe3)2] (3 and 4). In complexes 3 and 4 the vinyl chelating ligands form a novel four‐membered chelate ring. Single crystal of complex 3 was analyzed by X‐ray diffraction.
Heterozyklische Verbindungen mit fünfgliedrigen ESi4‐Ringen (E = Ga, In)
Authors: Uhl Werner , Jasper Beate , Lawerenz Andreas , Marschner Christoph , Fischer Jelena 
Published: October 2007

AbstractHeterocyclic Compounds Containing Five‐membered ESi4 Rings (E = Ga, In)Treatment of the dimeric indium(II) subhalide (In2R2Cl2)2 [R = C(SiMe3)3] possessing In‐In single bonds with the dipotassium tetrasilane dianion [K(18‐crown‐6)+]2[Si(SiMe3)2‐SiMe2‐SiMe2‐Si(SiMe3)2] (1) did not yield the corresponding six‐membered In2Si4 heterocycle by salt elimination. Instead cleavage of the In‐In bond occurred, and a compound containing a five‐membered InSi4 heterocycle (2) was isolated in a low yield. An ionic compound was formed with the indium atoms of the anions coordinated by two silicon and two chlorine atoms. The counterion [K2(18‐crown‐6)3]2+ contained two potassium atoms bridged by a crown ether molecule. Compound 2 and the corresponding gallium derivative 3 were obtained on a specific route by the reaction of the tetrasilane dianion with indium or gallium trichloride.
Fluorenone and Fluorene Complexes with a Slipped Triple Decker Structure DisplayingVariable Hapticity of ((Pentaalkyl)cyclopentadienyl)cobalt(I) Fragments
Authors: Guo Shengli , Hauptmann Ralf , Schneider Jörg J. 
Published: October 2007

AbstractThe reaction of the toluene triple decker complexes [{(η5‐Me5C5)Co}2μ‐(η6:η6‐toluene)] and [{(η5‐EtMe4C5)Co}2μ‐(η6:η6‐toluene)] with fluorenone leads to the first triple decker compounds [{(η5‐Me5C5)Co}2μ‐(η5:η4‐fluorenone)] (1) and [{(η5‐EtMe4C5)Co}2μ‐(η5:η4‐fluorenone)] (2) of this ligand. In 1 and 2 two [(η5‐RMe4C5)Co] fragments are bridged by a fluorenone ligand. One Co atom in 1 and 2 is coordinated by the five‐membered ring of the fluorenone ligand in a η5‐fashion, whereas the other Co atom is coordinated by the six‐membered ring in a η4‐fashion. The reaction of [{(η5‐Me5C5)Co}2μ‐(η6:η6‐toluene)] with 9H‐fluorene results in the formation of the first slipped triple decker [{(η5‐Me5C5)Co}2μ‐(η5:η3‐1H‐fluorene)] (3) of this ligand. One {(η5‐Me5C5)Co} fragment is bonded to the fluorene ligand via one of the six‐membered rings in a η3‐fashion, whereas the other {(η5‐Me5C5)Co} fragment is coordinated by the five‐membered ring of the fluorene ligand in a η5 manner. In 3 the coordination of the {(η5‐Me5C5)Co} fragments leads to tautomerism of the fluorene ligand, one H atom has been moved from C9 to C1, consequently 9H‐fluorene has been tautomerised to 1H‐fluorene.
Synthesis and Crystal Structure of [K([2.2]crypt)]2[HgGe9](dmf)
Authors: Boeddinghaus M. Bele , Hoffmann Stephan D. , Fässler Thomas F. 
Published: October 2007

AbstractThe title compound [K([2.2]crypt)]2[HgGe9](dmf) (1) has been obtained by reaction of elemental mercury with the binary phase of the formal composition K4Ge9 in dmf and after addition of [2.2]crypt. The X‐ray single crystal analysis shows that 1 contains polymeric $^{1}_{\infty}\rm [HgGe_{9}]^{2-}$ units in which Ge9 clusters are linked together by mercury atoms. The differences in the structures of 1 and the related compound [K([2.2.2]crypt)]2[HgGe9](en)2 2 are discussed.
Bimetallic Metal‐Organic Frameworks Containing the ${\rm [M(2,}x-{\rm pdc)^{2-}_{2}}]$ (M = Cu, Pd, Pt; x = 4, 5) Building Block – Synthesis, Structure, and Magnetic Properties
Authors: Humphrey Simon M. , Angliss Timothy J. P. , Aransay Marta , Cave Dale , Gerrard Lee A. , Weldon Gerald F. , Wood Paul T. 
Published: October 2007

AbstractNew bimetallic coordination polymers containing the ${\rm [Cu(2,}x-{\rm pdc)^{2-}_{2}}]$ (pdc = pyridine dicarboxylate, NC5H3(CO2)2; x = 4,5) ‘metalloligand’ unit, linked by MnII or CoII cations, have been obtained by hydrothermal synthesis. The metalloligand species K2[Cu(2,x−pdc)2(OH2)n]·mH2O (1, 2) were reacted under basic conditions with MnCl2 at 200 °C to form the compounds [CuMn(2,x−pdc)2] (3, x = 4; 4, x = 5), which are unexpectedly isostructural. Similar reaction with CoCl2 gave [Co3Cu2(2,4–pdc)4(μ4−OH)2(OH2)]2 (5), which has a ladder‐like framework based on Co‐hydroxide chains, and the 2‐dimensional sheet polymer [CoCu(2,4‐pdc)2(OH2)4] (6). A related CuII‐only chain compound, [Cu2(2,5−pdc)2(OH2)2]·4H2O (7) is also reported. The compounds 1–7 have been structurally characterized by single crystal X‐ray diffraction. The DC magnetic susceptibilites of 3–6 and [M3M′2(2,4−pdc)4(μ4−OH)2(OH2)] (8: M = Co, M′ = Pd; 9: M = Co, M′ = Pt; 10: M = Ni, M′ = Pd; 11: M = Ni, M′ = Pt) have been studied by SQUID magnetometry; 3 and 4 undergo antiferromagnetic ordering at low temperature, 5, 8 and 9 are metamagnets, 6 exhibits weak ferromagnetic exchange, while 10 and 11 show canted antiferromagnetism.
Two Routes of Electrophilic Addition and Unexpected Cluster Core Transformation in the Reactions of the K2[Fe3(μ3‐Q)(CO)9] (Q = Se, Te) Clusters with iPr2PCl
Authors: Pushkarevsky Nikolay A. , Virovets Alexander V. , Gerber Stefan , Konchenko Sergey N. 
Published: October 2007

AbstractThe reactions of the K2[Fe3(μ3‐Q)(CO)9] (Q = Se (K2[1a]), Te (K2[1b])) clusters with iPr2PCl in THF lead to the formation of mixtures of two products: [{Fe2(CO)6(μ‐PiPr2)}2(μ4,η2‐Q2)] (2a, 2b) and [Fe3(μ3‐Q)(μ‐PiPr2)2(CO)7] (3a, 3b). The compounds 3a and 3b are the products of addition of two {PiPr2}+ units to two Fe‐Fe edges of the initial cluster accompanied by the elimination of two CO‐ligands. The compounds 2a and 2b are the products of the initial cluster core fragmentation followed by assembling of the diiron fragments via Q–Q bond formation.In contrast to that the reaction of K2[1a] with iPr2PCl in CH2Cl2 leads mostly to the electrophilic insertion of {PiPr2}+ into the Se–Fe bond and formation of [(μ‐H)Fe3(μ3,η2‐SePiPr2)(CO)9] (4a). Reaction of K2[1b] with iPr2PCl in CH2Cl2 leads primarily to unstable unidentified products, although 2b and 3b in minor amounts present in the reaction solution. The crystal structures of 2a, 2b, 3a and 4a were determined by single‐crystal X‐ray diffraction.
Synthesis and Characterization of Organic‐Soluble Ag/AgBr Dimer Nanocrystals
Authors: Saunders Aaron E. , Popov Inna , Banin Uri 
Published: October 2007

AbstractColloidal metal/semiconductor hybrid nanoparticles, containing a Group I‐VII semiconductor (AgBr) coupled with a noble metal (Ag), are synthesized in an organic solvent using a single‐phase, room‐temperature method. Methanol is added to a precursor solution containing silver ions complexed with an alkylammonium bromide surfactant. The methanol appears to cause AgBr precipitation while also acting as a reducing agent for silver ions in solution; the reduced silver clusters grow preferentially onto the AgBr, forming dimer particles that are coated with an alkanethiol to passivate the surface. The structure and composition of the hybrid nanocrystals are studied using TEM and XRD. Surprisingly, despite the relatively broad size distribution of the colloids, the ratio between the diameters of the two domains is approximately constant. This suggests that both portions of the dimer nanocrystal nucleate and grow simultaneously, representing a new type of mechanism for the formation of hybrid nanoparticles.
Hydrothermal Synthesis and Characterization of a Layered Copper(II) Compound with Glycolate [HGLYCO]− and Lactate [HLACO]− Ligands
Authors: Balboa S. , Castiñeiras A. , Herle P. S. , Strähle J. 
Published: October 2007

AbstractA new bi‐dimensional neutral coordination polymer of formula $^{2}_{\infty}\rm [Cu(HGLYCO)(HLACO)$ (HGLYCO− = glycolate, HLACO− = lactate) has been hydrothermally synthesized and characterized by elemental analysis, IR, electronic and EPR spectroscopy, magnetic measurements, TG analysis and single crystal X‐ray diffractometry. Each CuII atom is six‐coordinated in a tetragonally distorted fashion by four oxygen atoms from carboxylate groups and two oxygen atoms of OH groups in a κ2O,O″:κO′ configuration. The α‐hydroxycarboxylate ligands are tridentate monoanionic systems and exhibit chelating and bridging behavior with the carboxylate groups adopting an anti‐anti mode.
Reactivity of the Unusually Structured Silicon Cluster Compound Si8(SitBu3)6
Authors: Wiberg Nils , Vasisht Sham‐Kumar , Fischer Gerd , Mayer Peter , Huch Volker , Veith Michael 
Published: October 2007

AbstractWhen Si8R*6 (R* = Si(tBu)3) is reacted with mild halogenation reagents like carbon tetrachloride, carbon tetrabromide, tin tetrachloride and iodine, new compounds are formed which besides the Si(tBu)3 groups have halide ligands and a silicon‐silicon back‐bone which is either cyclic, bicyclic or polycyclic. We here report on the molecular and crystal structures of four derivatives: Si5R*3Cl5 (9), Si4R*3Br5 (10), Si8R*4Cl6 (11) and Si8R**3I11 (12). The molecule 9 has a bicyclic silicon back‐bone with a three‐ and four‐membered cycle sharing one edge, 10 is monocyclic with a four membered silicon‐silicon‐ring, 11 is polycyclic and can be derived from a Si8‐cube and 12 is bicyclic with a four‐ and five‐membered silicon ring sharing one edge.We also propose some possible reaction mechanisms which follow from observations found during our experiments.
Coordination Architectures of Large Heavy Metal Cations (Hg2+ and Pb2+) with Bis‐tridentate Ligands: Solution and Solid‐State Studies
Authors: Ramírez Juan , Stadler Adrian‐Mihail , Harrowfield Jack M. , Brelot Lydia , Huuskonen Juhani , Rissanen Kari , Allouche Lionel , Lehn Jean‐Marie 
Published: October 2007

AbstractSolution and solid state studies of the complexation of Hg2+ and Pb2+ by the homologous bis‐tridentate ligands 1 and 2H2 obtained by condensation of bis(methylhydrazino)phenylpyrimidine and bis(hydrazino)phenylpyrimidine, respectively, with pyridine‐2‐carboxaldehyde, have provided evidence for the formation of both grid and rack species. With Hg2+, there is little indication for other than grid species, the grid complex [Hg4(2H2)4](CF3SO3)8 being characterised crystallographically. With Pb2+, the only crystalline species readily isolated are rack complexes of the ligands 1 and 2H2.
Thiosilicate der Selten‐Erd‐Elemente: IV. Die quasi‐isostrukturellen Verbindungen NaSm3S3[SiS4], CuCe3S3[SiS4], Ag0,63Ce3S2,63Cl0,37[SiS4] und Sm3S2Cl[SiS4] – Synthese, Kristallstruktur und Untersuchungen zur Silberionendynamik
Authors: Hartenbach Ingo , Nilges Tom , Schleid Thomas 
Published: October 2007

AbstractThiosilicates of the Rare‐Earth Elements: IV. The quasi‐isostructural Compounds NaSm3S3[SiS4], CuCe3S3[SiS4], Ag0,63Ce3S2,63Cl0,37[SiS4] and Sm3S2Cl[SiS4] – Synthesis, Crystal Structure and Investigations of the Silver‐Cation MotionThe four lanthanoid(III) thiosilicates NaSm3S3[SiS4] (1), CuCe3S3[SiS4] (2), Ag0,63Ce3S2,63Cl0,37[SiS4] (3) and Sm3S2Cl[SiS4] (4) crystallize all hexagonally in the non‐centrosymmetric space group P63 (no. 173) showing basically the same structure. Besides an eightfold square‐antiprismatic sulfide coordination sphere about the M3+ cations these compounds display discrete tetrahedral thiosilicate units [SiS4]4− which are trigonally distorted. All tops of the remaining pyramids point into the same direction along the c axis and therefore the structure needs to be non‐centrosymmetric. However, the main feature of these crystals are channels along [001], built up by non‐silicon bonded sulfide anions and providing trigonal planar (CN = 3) and trigonal antiprismatic (CN = 6) voids. In the sodium derivative (1) the Na+ cations reside almost in the center of the latter ones exhibiting a trigonally distorted octahedral surrounding (CN = 6) while the Cu+ cations of the respective thiosilicate (2) are situated in the middle of an (S2−)3 triangle (CN = 3), just 7 pm above its plane. The same is true for the silver compound (3) with the exception of the Ag+ cations sitting about 53 pm above the sulfide triangle and showing a marked under‐occupation along with a very large U33 displacement parameter. These facts lead to the assumption that (3) could be a promising material for ionic Ag+ conduction. In order to maintain electroneutrality the silver derivative has to contain a certain amount of Cl− anions (CeCl3 was used as fluxing agent) substituting S2− which was doubtlessly confirmed by WDX analyses. In the absence of any monovalent cation (A+) the analogous structure is realized in (4) displaying an empty channel along [001] and a complete substitution of one sulfide by one chloride anion per formula unit, also confirmed by electron‐beam microanalysis.
Effect of Linker Length in semi‐flexible 4,4′‐Bispyridyl Ligands with Functional Spacer on the Architecture of their M(NO3)2 Complexes
Authors: Qiao Yu‐Qin , Lü Xing‐Qiang , Su Cheng‐Yong , Kang Bei‐Sheng 
Published: October 2007

AbstractTwo semi‐flexible 4,4′‐bispyridyl ligands, N,N′‐bis(4‐pyridylethyl) pyromellitic diimide (4‐pepmd) and N,N′‐bis(4‐pyridylmethyl)pyromellitic diimide (4‐pmpmd), with different linker length, and their coordination polymers obtained by reaction with M(NO3)2 (M = Co or Cd) in mixed CHCl3 and ROH solvents are reported. 2D (6,3) brick‐wall networks with Py3M nodes for the isostructural [Co(4‐pepmd)1.5(NO3)2]n · nCHCl3 · 2nH2O · nEtOH (1) and [Cd(4‐pepmd)1.5(NO3)2]n · nCHCl3 · nH2O · 2nMeOH (2), and 1D zigzag chain with Py2M nodes for [Co(4‐pmpmd)(NO3)2]n · nCHCl3 (3) are observed. The ligand 4‐pepmd with longer linker –(CH2)2– induces exclusively trispyridyl building blocks and 2D networks in its Co and Cd complexes, while the coordination preference of metal ions works more effectively for shorter linked 4‐pmpmd to give either 1D (for Co, 3) or 2D [Cd(4‐pmpmd)1.5(NO3)2]n · nCHCl3 (4) [10] polymer depending on the size of the metal ion.
Synthese und Kristallstruktur der spirocyclischen Gallium‐ und Indium‐Chalkogen‐Heterocyclen [(Me2Ga)6S(SSiMe3)4], [(Me2Ga)6Se(SeSiMe3)4] und [(Me2In)6S(SSiMe3)4]
Authors: Kluge Oliver , Puidokait Martin , Biedermann Ralf , Krautscheid Harald 
Published: October 2007

AbstractSynthesis and Crystal Structures of Spirocyclic Gallium and Indium Chalcogen Heterocycles [(Me2Ga)6S(SSiMe3)4], [(Me2Ga)6Se(SeSiMe3)4] and [(Me2In)6S(SSiMe3)4]The isostructural title compounds [(Me2M)6E(ESiMe3)4] (M = Ga, In; E = S, Se) crystallize in space group C2/c and consist of two M3E3 rings in twist conformation, sharing a common chalcogen atom. The reactivity of the remaining M–CH3 and E–SiMe3 bonds can be used for further reactions.
Cyclopentadienyl Tantalum(V) Complexes with Primary and Secondary Ferrocenylphosphine Ligands
Authors: Kalio René , Lönnecke Peter , Cinquantini Arnaldo , Zanello Piero , Hey‐Hawkins Evamarie 
Published: October 2007

AbstractThe reaction of [Cp*TaCl4] (1a, Cp* = C5Me5) or [Cp′TaCl4(THF)] (1b, Cp′ = C5MeH4) with PH2Fc [Fc = Fe(η5‐C5H5)(η5‐C5H4)] and PH2CH2Fc gives the primary ferrocenylphosphine complexes [CpRTaCl4(PH2Fc)] [CpR = Cp* (2a), Cp′ (2b)] and [CpRTaCl4(PH2CH2Fc)] [CpR = Cp* (3a), Cp′ (3b)], respectively. 1 reacts with (PH2)2fc [fc = Fe(η5‐C5H4)2] or with the new secondary phosphine PH(CH2Fc)2 to give the ferrocenyl‐bridged complexes [{(CpRTaCl4)[PH2(η5‐C5H4)]}2Fe] [CpR = Cp* (4a), Cp′ (4b)] or [CpRTaCl4{PH(CH2Fc)2}] [CpR = Cp* (5a), Cp′ (5b)]. Complexes 1b and 2–5 were characterised spectroscopically (1H, 13C, 31P NMR, MS, IR) and 1b, 2a, 3a, 4a, and 5a also by X‐ray crystallography. The electrochemical behaviour of complexes 3a and 5b exhibits complicated electron transfer processes, which are due to the complex redox activity of the corresponding ferrocenylphosphine ligands PH2CH2Fc and PH(CH2Fc)2.
Foreign aid as a Promotional Strategy
Authors: Jolly Curtis M. , Gadbois Millie A. 
Published: October 2007

Developed countries are motivated by several forces when allocating aid to developing countries. The forces could be humanitarian in one country, and commercial self-interests in another. The principal objective of this study was to determine the effectiveness of aid as a promotional strategy for trade, and to investigate whether major donor countries are optimally allocating their aid resources to increase their export and total trade. Models were developed to explore the effectiveness of aid as a promotional instrument for exports and total trade. Donor exports and total trade were expressed as functions of aid, per capita GNP of the recipient country, and aid from competing donors. The study showed that exports and total trade responded to total expected aid contributions and per capita GNP of the recipient countries. Also, all donors, but one, were maximizing the returns to aid, given the level of trade with recipient countries and will be reluctant to increase aid flows, given the current trade level.
Transfusion Alert for Patients with Curable Cancer
Authors: Yamashita Keishi , Sakuramoto Shinichi , Kikuchi Shiroh , Katada Natsuya , Kobayashi Nobuyuki , Watanabe Masahiko 
Published: October 2007

AbstractBackgroundPerioperative transfusion (POT) is a negative prognostic factor for outcome in cancer patients undergoing surgery, and splenectomy (SPL) has been suggested to help obviate this negative effect. However, the prognostic independence among related factors and clinical significance of the interaction remains elusive.Patients and methodsBetween January 1, 1990 and January 31, 2005, a total of 200 patients with proximal gastric cancer classified as having stage IB to III disease after curative resection were enrolled at Kitasato University Hospital in a retrospective manner, according to a previous report by Weitz et al.FindingsPOT was reconfirmed to be a potent univariate prognostic predictor in this model (p< 0.0001). The tendency was further augmented in patients without SPL, suggesting that SPL can counteract the negative aspects of POT. A multivariate analysis including related factors revealed that POT was one of the most potent independent prognostic factors, as were stage and age. Stratification analysis following the JCGC staging system revealed that the outstanding prognostic difference according to POT was recognized in patients anticipated to be cured, such as those with stage IB (p= 0.012) or II (p= 0.003) but not stage III. SPL could dramatically improve the prognosis with POT in stage IB patients but modestly if at all in those with stage II or III.InterpretationOur findings support the need for a clinical alert against POT throughout the course of cancer treatment, especially for curable disease; thus, POT should be carefully considered from an oncologic point of view. Appropriate strategies to minimize POT should be urgently developed.
Surgical Site Infection Among Women Discharged with a Drain In Situ After Breast Cancer Surgery
Authors: Felippe Wilza Andrade Barbosa , Werneck Guilherme Loureiro , Santoro‐Lopes Guilherme 
Published: October 2007

AbstractBackgroundThere are scarce data on the factors associated with surgical site infection (SSI) among women who are discharged with a drain in situ after breast cancer surgery. The aim of this study was to determine the incidence and the factors associated with SSI in a center where women are routinely discharged with a drain in place.MethodsA prospective cohort study included 354 women who underwent surgical treatment for breast cancer at a referral center in Rio de Janeiro, Brazil.ResultsSSI was diagnosed in 60 patients (17%) after a median follow‐up of 17 days. Most infections were caused by Staphylococcus aureus. The probability of bacterial colonization of the drain was 33% on postoperative day (POD) 7 and rose to 80.8% up to the POD 14. In 83% of the cases of microbiologically documented infection, SSI was caused by the same bacterial species that had been previously isolated from the drainage fluid. In multivariate regression analyses, age 50 years (p < 0.001), skin flap necrosis (p < 0.001), and bacterial colonization of the drain (p = 0.03) were independently associated with a higher incidence of SSI.ConclusionThe incidence of SSI among women who were routinely discharged with a drain in place was high. Older age, skin flap necrosis, and bacterial colonization of the drain were independent predictors of SSI. Modifications of the surgical technique aimed at reducing the risk of wound necrosis and early removal of the drain may contribute to lowering the risk of SSI among these patients.