bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and efficacy of remifentanil target-controlled infusion for conscious sedation in a pregnant woman: a case report
Authors: Munafo’ Camilla , Loperfido Antonella , Mammarella Fulvio , Crosti Arianna , Iannilli Federico , Millarelli Francesca Romana , Bellocchi Gianluca , Tritapepe Luigi 
Published: March 2024

Abstract
Background
Every year 2% of pregnant women undergo nonobstetric surgical interventions worldwide. According to the American College of Obstetricians and Gynecologists Committee on Obstetric Practice, pregnant women should never be denied the most appropriate surgical treatment, regardless of the trimester of pregnancy. However, additional attention should be paid during the first trimester since it has the highest risk of inducing teratogenic mutations; additionally, during the third trimester, due to the possibility of preterm birth and low birth weight of the newborn, great care should be paid.

Case presentation
We present the case of a Caucasian 36-year-old woman during her 21st week of pregnancy, with a normal-sized fetus, according to the gestational age on ultrasound exam, and with no additional risk factors. The patient referred to an increasing nasal obstruction associated with rhinorrhea of the left nasal cavity. She also reported episodes of sleep apnea and hyposmia. The patient received a detailed otolaryngological examination, which allowed for identification of a mass within the left nasal cavity. The subsequent nasal endoscopy confirmed a grayish polypoid mass lesion with a multinodular surface occupying the entire left nasal fossa. The lesion totally obliterated the left maxillary sinus, resulting in obstruction of the anterior osteomeatal unit and ethmoidal sinusitis. She was referred for a functional endoscopic sinus surgery using analgosedation with remifentanil target-controlled infusion.

Discussion and conclusion
To the very best of our knowledge, this is the first case described in English literature about the use of analgosedation with remifentanil target-controlled infusion for otolaryngology surgery, specifically in functional endoscopic sinus surgery. It could be an interesting option to avoid the use of inhaled anesthetics that could induce fetal damage, especially during the first months of pregnancy. Furthermore, patient intubation is not necessary, which avoids cases of difficult intubation or any trauma to the airways. An adequate informed consent and appropriate compliance are elements of paramount importance in tailoring the anesthetic strategy for pregnant women who need nonobstetric surgical management.
Well-posed fixed point results and data dependence problems in controlled metric spaces
Authors: Sagheer D. , Batul S. , Daim A. , Saghir A. , Aydi H. , Mansour S. , Kallel W. 
Published: March 2024

AbstractThe present research is aimed to analyze the existence of strict fixed points (SFPs) and fixed points of multivalued generalized contractions on the platform of controlled metric spaces (CMSs). Wardowski-type multivalued nonlinear operators have been introduced employing auxiliary functions, modifying a new contractive requirement form. Well-posedness of obtained fixed point results is also established. Moreover, data dependence result for fixed points is provided. Some supporting examples are also available for better perception. Many existing results in the literature are particular cases of the results established.
The gateway reflex regulates tissue-specific autoimmune diseases
Authors: Tanaka Yuki , Ohki Izuru , Murakami Kaoru , Ozawa Satoshi , Wang Yaze , Murakami Masaaki 
Published: March 2024

AbstractThe dynamic interaction and movement of substances and cells between the central nervous system (CNS) and peripheral organs are meticulously controlled by a specialized vascular structure, the blood–brain barrier (BBB). Experimental and clinical research has shown that disruptions in the BBB are characteristic of various neuroinflammatory disorders, including multiple sclerosis. We have been elucidating a mechanism termed the “gateway reflex” that details the entry of immune cells, notably autoreactive T cells, into the CNS at the onset of such diseases. This process is initiated through local neural responses to a range of environmental stimuli, such as gravity, electricity, pain, stress, light, and joint inflammation. These stimuli specifically activate neural pathways to open gateways at targeted blood vessels for blood immune cell entry. The gateway reflex is pivotal in managing tissue-specific inflammatory diseases, and its improper activation is linked to disease progression. In this review, we present a comprehensive examination of the gateway reflex mechanism.
Preoperative predictive parameters for accurate detection of stage IV endometriosis
Authors: Abohashim Mohmed Fathy , Etman Waleed M. , Wasfy Mohamed A. , Abdallah Amany M. , Hamed Enas Mahmoud , Eladl Mona Mahmoud , Mohammed Sherif Yehia , Harb Ola A. , Edris Fawaz E. , Alshaikh Ahmed Baker A. , Lashin Mohamed Elbakry 
Published: March 2024

Abstract
Background
Surgery is the main line of treatment of endometriosis. Patients with stage IV endometriosis have more extensive adhesions, which make the surgery difficult. There are no accurate non-invasive predictive preoperative parameters of stage IV endometriosis and no consensus has been reached.
Therefore, the aim of the present study was to evaluate and detect preoperative non-invasive parameters for the detection of stage IV endometriosis.

Patients and methods
In the present study, we included 150 females admitted for surgical removal of endometriosis. We scored and classified endometriosis into four stages according to the revised ASRM classification. We compared between baseline characteristics of patients with different stages of endometriosis, and then we selected the best combination of diagnostic and predictive parameters of stage IV endometriosis.

Results
Predictors of stage IV endometriosis and indicators for safety surgery were as follows: VAS ≥ 4 (p < 0.001), fixed uterus (p = 0.005), fixed ovarian cysts (p < 0.001), tender uterosacral ligament nodule (p < 0.001), tender rectovaginal septum nodule (p = 0.003), bilateral endometriosis (p < 0.001), and sum of sizes of endometriotic nodules (p < 0.001).

Conclusion
Fixed uterus, fixed ovarian cysts, tender uterosacral ligament nodule, tender rectovaginal septum nodule, bilateral endometriosis, and indications for surgery were significantly considered adequate predictive markers for stage IV endometriosis.
The coagulation changes associated with acute variceal bleeding in patients with HCV-induced cirrhosis as assessed by rotational thromboelastometry
Authors: El-Makarem Mona A. Abu , Mohammad Aml A. , Afifi Ola A. , Abbas Nehal I. , El-Zaher Tarek A. Abd , Halim Safaa M. Abdel , El-Fattah Aliaa S. Abd 
Published: March 2024

Abstract
Background and objectives
Alterations of hemostasis in patients with decompensated cirrhosis are complex. Accordingly, standard coagulation tests are not feasible to evaluate bleeding risk in these patients. The aim of this study was to assess the coagulation kinetics in cirrhotic patients with variceal bleeding using rotational thromboelastometry (ROTEM). ROTEM including EXTEM, INTEM, and FIBTEM which represent extrinsic, intrinsic pathways, and fibrinogen activity, respectively, was measured in 60 cirrhotic patients with variceal bleeding who were compared to 60 patients with stable cirrhosis. APTEM was optionally performed to evaluate fibrinolysis.

Results
Overall, cirrhosis patients displayed features of hypofibrinolysis, whereas the state of hypocoagulability was significantly higher in cirrhotic patients with variceal bleeding (61.7% versus 30%, p = 0.001). Values of clot formation time (CFT) by EXTEM and INTEM correlated positively with those of model for end-stage liver disease score (r = 0.529, p = 0.001, and r = 0.595, p < 0.001, respectively). Furthermore, in a multivariate analysis, values of CFT in both assays were significantly associated with increased risk of 1.9 (95% CI = 1.04–2.45, p = 0.02) and of 1.78 (95% CI = 1.02–2.14, p = 0.01), respectively, for occurrence of variceal bleeding.

Conclusion
Cirrhotic patients with variceal bleeding frequently showed a hypocoagulable state that is triggered by thrombocytopenia and/or hypofibrinogenemia. CFT by EXTEM and INTEM seemed to be an extra marker for disease severity and prognosis in cirrhosis patients, in addition to its valuable role in prediction of variceal bleeding in these patients. However, large multicenter studies have yet been required.
Working Paper 49: Dirty deals – Case studies on corruption in waste management and trade
Authors: Isarin Nancy , Baez Camargo Claudia , Cabrejo le Roux Amanda 
Published: March 2024

Waste management is a huge industry at the local, national and international levels. Public services play a key role in dealing especially with waste generated by households. Getting waste management right is essential if we are to achieve a circular economy and the Sustainable Development Goals.
Complex legal frameworks and their weak implementation open up spaces for criminals to profit from illegally managing or trading in waste. The consequences on the environment and human health can be severe. The role of corruption in crimes involving waste is unexplored.
An initial analysis shows the potential for corruption to play a role in:

influencing policy decisions involving waste management;
corrupt deals involving the selection of waste management companies linked to powerful elites;
schemes to gain lucrative waste management contracts through systematic bribery;
illegal imports of hazardous substances for profit, avoiding or suppressing formal controls.

The report explores five case studies (Albania, Lebanon, North Macedonia, Canada–Philippines, US–South America) and proposes a typology of corruption patterns in crimes involving waste management and trade.
Comparative evaluation of two different xenogenic acellular matrices on full-thickness skin wound healing
Authors: Kumar Vineet , Kumar Naveen , Gangwar Anil K , Singh Rajendra 
Published: March 2024

Objective: The purpose of the study was to compare the healing potential of bubaline small intestinal matrix (bSIM) and fish swim bladder matrix (FSBM) on full-thickness skin wounds in rabbits. Method: Four full-thickness skin wounds (each 20×20mm) were created on the dorsum of 18 rabbits that were divided into three groups based on treatment: untreated sham control (I), implanted with double layers of bSIM (II) and implanted with double layers of FSBM (III). Macroscopic, immunologic and histologic observations were made to evaluate wound healing. Results: Gross healing progression in the bSIM and FSBM groups showed significantly (p<0.05) less wound contraction compared with the sham group. The IgG concentration in rabbit sera was significantly (p<0.05) lower in the FSBM group compared with the bSIM group by enzyme-linked immunosorbent assay. The stimulation index of peripheral blood lymphocytes was significantly (p<0.05) lower in the FSBM group compared with the bSIM group by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Implantation of FSBM resulted in improved re-epithelialisation, neovascularisation and fibroplasia. Conclusion: The FSBM is a more effective dermal substitute when compared with the bSIM for full-thickness skin wound repair in rabbit.
The experiences of internationally educated nurses who joined the nursing workforce in England
Authors: Lanada Jose Ariel , Culligan Kate 
Published: March 2024

The number of internationally educated nurses working in the NHS has skyrocketed over the past three decades. This study examines their experiences of working and living in England Objectives: There is limited literature on the experiences of internationally educated nurses (IENs) who have joined NHS trusts in England in the past 20 years. The objectives of this integrative review included exploring and analysing the experiences of IENs in the NHS in England and identifying the cultural, pastoral and training needs of IENs during their first 2 years working in England and providing research-informed recommendations to better support IENs. Design: An integrative review of primary research studies using quantitative, qualitative, and mixed methods of data collection. Data source: CINAHL, British Nursing Index and Google Scholar. Results: Nine articles met the inclusion criteria for this integrative review. All articles contributed to the findings of three main analytical themes: expectations, challenges and belongingness. Conclusion: Limited research fully met the search criteria. This was concerning since IENs have been working in the NHS for decades, yet so few primary studies have been conducted into their experiences. The findings were in line with previous studies, which found that IENs faced challenges both in the workplace and in settling into an English way of life, and often reported feeling that they were not treated equally to their English counterparts. This integrative review raises issues and increases awareness of how the NHS in England can better support IENs transitioning into their new life and ways of working, to further aid recruitment and retention of the international nursing workforce.
Association between children’s caregivers time preferences and childhood overweight and obesity in Mexico
Authors: Molina Mariana , Guindon Godefroy Emmanuel , Anderson Laura N. , Tarride Jean-Eric 
Published: March 2024

Background
Parents or children’s primary caregivers are a key influence on child weight as both decision makers and role models for eating patterns, physical activity, and other social behaviors. It is unknown whether caregivers’ time preferences are associated with overweight or obesity in children. The primary objective was to estimate the association between parents’ or caregivers’ time preferences and children having overweight or obesity in Mexico.

Methods
A cross-sectional study was conducted using a representative survey of the Mexican population. A multinomial logistic model was used to examine the association between parents’ or caregivers’ time preferences (patience and time consistency) and child overweight or obesity, adjusting for potential confounders.

Results
The study included 9,102 children (mean age 10, 43% female) and 5,842 caregivers (mean age 37; 95% female). Intertemporal preference was strongly associated with increased odds of overweight or obesity in children. A medium patient caregiver had higher odds of having overweight (adjusted OR: 1.73; 95% CI: 1.19, 2.52). Similarly, having a caregiver with a present (OR: 2.52; 95% CI: 1.72, 3.70) or future bias (OR: 1.48; 95% CI: 1.11, 1.98) was associated with higher odds of obesity.

Conclusion
Caregivers’ time preferences were associated with having overweight and obesity in children and should be considered when developing policies to reduce children’s obesity status.
The prevalence and determinants of blood pressure control among hypertension patients in eastern Zimbabwe: A cross-sectional study
Authors: Mundagowa Paddington Tinashe , Zambezi Pemberai , Muchemwa-Munasirei Priscillah 
Published: March 2024

Background
Uncontrolled blood pressure (BP), also known as hypertension, is a leading cause of morbidity and mortality globally. Lowering the elevated BP can significantly reduce one’s risk for cardiovascular diseases. This study aimed to ascertain the determinants of BP control among hypertension patients.

Methods
The data analyzed were from the exploratory survey of the Home Management of Hypertension (HoMHyper) project in eastern Zimbabwe. Hypertension patients were selected from the Chronic Disease Registers of five public health clinics using simple random sampling. A pretested interviewer-administered questionnaire was used to collect data, and the patient’s BP was measured. The primary outcome, BP control, was used as a categorical variable (controlled vs. uncontrolled) to conduct a bivariate analysis. Variables significant at p<0.2 were included in the multivariable logistic regression analysis to control for confounding. Statistical significance in the final model was set at p<0.05.

Results
Data from 321 hypertension patients were analyzed; their mean age was 62.3±11.9 years. The prevalence of controlled BP was 41.4% (95% Confidence interval-CI = 36.0%-46.9%). After adjusting for confounding, patients’ residence and medication stocks were associated with BP control. Patients who resided in high-density suburbs had higher odds of uncontrolled BP than those who resided in middle- and low-density suburbs (Adjusted odds ratios-AOR = 2.5; 95% CI = 1.4–4.4; p<0.01). Hypertension patients who experienced medication stockouts over the last six months had higher odds of uncontrolled BP than patients who did not experience stockouts (AOR = 1.8; 95% CI = 1.1–2.9).

Conclusion
BP control among hypertension patients was suboptimal. Patient residence and antihypertensive medication stockouts were independent predictors of blood pressure control. We recommend exploring sustainable financing through private-public partnerships to ensure the availability of subsidized antihypertensive medication.
Comparison of five different disseminated intravascular coagulation criteria in predicting mortality in patients with sepsis
Authors: Zafar Amara , Naeem Filza , Khalid Muhammad Zain , Awan Safia , Riaz Muhammad Mehmood , Mahmood Saad Bin Zafar 
Published: March 2024

Objective
Even though patients with sepsis and DIC have a higher mortality rate compared to those without DIC, screening for DIC is not currently part of sepsis management protocols. This may be due to a lack of literature on the frequency of DIC occurrence in sepsis patients, as well as the absence of evidence on the optimal DIC criteria to use for identifying DIC and predicting mortality among the five criteria available. To address this gap, this study investigates the predictive value of five different criteria for diagnosing DIC and its relationship to patient outcomes in our population of sepsis patients.

Methods
In the Medicine department of Aga Khan University Hospital, a retrospective observational study was conducted, enrolling all adult patients with International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) coding of sepsis and clinical suspicion of DIC between January 2018 and December 2020. To diagnose DIC, five different criteria were utilized, namely the International Society of Thrombosis and Hemostasis (ISTH), the Korean Society on Thrombosis and Hemostasis (KSTH), the Japanese Association for Acute Medicine (JAAM), the revised-JAAM (RJAAM), and the Japanese Ministry of Health and Welfare (JMHW). The study analyzed the sensitivity, specificity, negative predictive value, positive predictive value, and accuracy of these five criteria, as well as the overall prediction of mortality.

Results
Of 222 septic patients included in this study with clinical suspicion of DIC, 94.6% of patient had DIC according to KSTH criteria, followed by JAAM (69.4%), ISTH (64.0%), JMHW (53.2%) and lastly R-JAAM (48.6%). KSTH had sensitivity of 95.4% in diagnosing DIC and predicting mortality with a positive predictive value of 70% but specificity of 7.3% only. JAAM had sensitivity of 75.9%, positive predictive value of 75.9% with a specificity of 45.5%. ISTH had sensitivity of 69.4%, positive predictive value 75.3% and specificity of 48.5%.

Conclusion
DIC can impose a significant burden on septic patients and its presence can lead to higher mortality rates. Early detection through screening for DIC in septic patients can potentially reduce mortality. However, it is necessary to identify the most appropriate diagnostic criteria for each population, as various criteria have demonstrated different performance in different populations. Establishing a gold standard for each population can aid in accurate diagnosis of DIC.
Influence of type of violence on women’s help-seeking behaviour: Evidence from 10 countries in sub-Saharan Africa
Authors: Ayebeng Castro , Dickson Kwamena Sekyi , Ameyaw Edward Kwabena , Adde Kenneth Setorwu , Paintsil Jones Arkoh , Yaya Sanni 
Published: March 2024

Background
Intimate partner violence (IPV) is a major public health concern that mostly impacts women’s health and social well-being. This study explored how the various types of IPV (physical, sexual, and emotional) including women’s experience of childhood violence influence their help-seeking behavior in sub-Saharan Africa (SSA).

Methods
We analyzed data from the most recent Demographic and Health Surveys (DHS), carried out between 2018 and 2021. The outcome variable was help-seeking behavior. Descriptive and inferential analyses were carried out. The descriptive analysis looked at the bivariate analysis between the country and outcome variables. Using a binary logistic regression model, a multivariate analysis was utilized to determine the association between the outcome variable and the explanatory variables. Binary logistic regression modelling was used based on the dichotomous nature of the outcome variable. The results were sample-weighted to account for any under- or over-sampling in the sample.

Results
The proportion of women who sought help for intimate partner violence was 36.1 percent. This ranged from 19.2 percent in Mali to 49.6 percent in Rwanda. Women who experienced violence in childhood (OR = 0.75, CI = 0.69, 0.82) have a lower likelihood of seeking help compared to those who did not experience violence in their childhood. Women who had experienced emotional violence (OR = 1.94, CI = 1.80, 2.08), and physical violence (OR = 1.37, CI = 1.26, 1.48) have a higher likelihood of seeking help compared to those who have not. Women with secondary educational levels (aOR = 1.13, CI = = 1.02, 1.24) have a higher likelihood of seeking help compared to those with no education. Cohabiting women have a higher likelihood (aOR = 1.22, CI = 1.10, 1.35) of seeking help compared to married women.

Conclusion
The study highlights the importance of early identification of IPV and fit-for-purpose interventions to demystify IPV normalization to enhance women’s willingness to seek help. The study’s findings suggest that education is crucial for increasing women’s awareness of the legalities surrounding IPV and available structures and institutions for seeking help.