bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deriving the Transdiagnostic Scales From the Personality Assessment Inventory and SPECTRA: Indices of Psychopathology: A Demonstration
Authors: Blais Mark A. , Kelley Shannon E. , Ruchensky Jared R. , Richardson Laura A. , Massey Christina , Stein Michelle B. 
Published: April 2024

ABSTRACTTransdiagnostic models of psychopathology address many of the shortcomings common to categorical diagnostic systems. These empirically derived models conceptualize psychopathology as a few broad interrelated and hierarchically arranged dimensions, with an overarching general psychopathology dimension, the p‐factor, at the apex. While transdiagnostic models are gaining prominence in mental health research, the lack of available tools has limited their clinical translation. The present study explored the potential of creating transdiagnostic scales from the joint factor structure of the Personality Assessment Inventory, Alternative Model of Personality Disorder trait scales (AMPD), and the clinical scales of the SPECTRA: Indices of Psychopathology (SPECTRA). Exploratory factor analysis in a clinical sample (n = 212) identified five factors corresponding to the Negative Affect/Internalizing, Detachment, Antagonism/Externalizing, Disinhibition/Externalizing, and Thought Disorder transdiagnostic dimensions. Goldberg's “Bass‐Ackward” method supported a hierarchical structure. Five composite transdiagnostic scales were created by summing each factor's highest loading PAI and SPECTRA scales. A global psychopathology scale was created by summing the five composite scales. All the composite scales demonstrated adequate internal consistency. Correlations between the composite scales and the NEO Five‐Factor Inventory‐3 provide initial validity evidence for four composite and global scales. The composite thought disorder scale had no conceptually corresponding NEO domain. Clinical implications and study limitations are discussed.
Characterization of genetic diversity of greens‐type hybrid bermudagrass selections through SSR markers and morphological analysis
Authors: Earp Ryan , Moss Justin Quetone , Fang Tilin , Anderson Michael , Wu Yanqi 
Published: April 2024

AbstractThe development of Tifgreen bermudagrass, and the subsequent mutations of this cultivar, has revolutionized the game of golf in the southern United States as superintendents have access to high‐quality putting surface capable of withstanding hot summers. However, the lack of genetic diversity may make them vulnerable to various pests and the low tolerance to freeze temperatures may make them susceptible to winterkill. In recent years, Oklahoma State University and other universities have begun to create new interspecific F1 hybrids between common (Cynodon dactylon) and African bermudagrasses (C. transvaalensis) for putting greens. The objectives of this study were to investigate the genetic diversity and variation among 14 experimental genotypes and two standard cultivars (TifEagle and Tifdwarf). Simple sequence repeat (SSR) markers and morphological characteristics were used to evaluate the genetic relationships and variation among the 16 genotypes. Results showed significant variation for 11 vegetative traits and two reproductive traits. The phenotypic coefficient of variation was greatest for the third internode length and the least for the first leaf angle for both the field and greenhouse trials. The morphological cluster analysis also showed variation between the two trial environments. The SSR marker cluster analysis showed the 16 genotypes were grouped into four major groups, with a similarity coefficient ranging from 0.44 to 1. The highest similarity was found among the two commercial standards and an experimental ultradwarf from Florida. Several new genotypes (OKC3920, 5 × 23, 11 × 2, 19 × 19, and 34 × 20) were also grouped with the ultradwarf genotypes in the morphological cluster analysis, showing the possibility of achieving similar morphological traits with new genetics. Further field evaluations are needed to determine the performance of these genotypes under low mowing heights.
Engineering exosomes to reshape the immune microenvironment in breast cancer: Molecular insights and therapeutic opportunities
Authors: Cao Jilong , Lv Gang , Wei Fang 
Published: April 2024

AbstractBackgroundBreast cancer remains a global health challenge, necessitating innovative therapeutic approaches. Immunomodulation and immunotherapy have emerged as promising strategies for breast cancer treatment. Engineered exosomes are the sort of exosomes modified with surface decoration and internal therapeutic molecules. Through suitable modifications, engineered exosomes exhibit the capability to overcome the limitations associated with traditional therapeutic approaches. This ability opens up novel avenues for the development of more effective, personalized, and minimally invasive interventions.Main bodyIn this comprehensive review, we explore the molecular insights and therapeutic potential of engineered exosomes in breast cancer. We discuss the strategies employed for exosome engineering and delve into their molecular mechanisms in reshaping the immune microenvironment of breast cancer.ConclusionsBy elucidating the contribution of engineered exosomes to breast cancer immunomodulation, this review underscores the transformative potential of this emerging field for improving breast cancer therapy.Highlights
Surface modification of exosomes can improve the targeting specificity.
The engineered exosome‐loaded immunomodulatory cargo regulates the tumour immune microenvironment.
Engineered exosomes are involved in the immune regulation of breast cancer.
Density data for Lake Erie benthic invertebrate assemblages from 1930 to 2019
Authors: Burlakova Lyubov E. , Karatayev Alexander Y. , Hrycik Allison R. , Daniel Susan E. , Mehler Knut , Hinchey Elizabeth K. , Dermott Ronald , Griffiths Ronald , Denecke Lillian E. 
Published: April 2024

AbstractBenthic invertebrates are important trophic links in food webs and useful bioindicators of environmental conditions, but long‐term benthic organism abundance data across broad geographic areas are rare and historic datasets are often not readily accessible. This dataset provides densities of benthic macroinvertebrates collected from 1930 to 2019 during surveys in Lake Erie, a Laurentian Great Lake. The surveys were funded by the governments of the United States and Canada to investigate the status and changes in the benthic community. From the total of 21 lake‐wide and basin‐wide benthic surveys conducted in Lake Erie from 1929 to 2019, we were able to acquire data for 17 surveys, including species‐level data for 10 surveys and data by higher taxonomic groups for seven surveys. Our amassed Lake Erie dataset includes data from 11 surveys (including five with species‐level data) conducted in the western basin in 1930–2019, seven surveys (six with species‐level data) in the central basin, and eight surveys (seven with species‐level data) in the eastern basin (1973–2019). This Lake Erie dataset represents the most extensive temporal dataset of benthic invertebrates available for any of the Laurentian Great Lakes. Benthic samples were collected using Ponar or Shipek bottom dredges and taxa densities were calculated as individuals per square meter using the area of the dredge. Density data are provided for taxa in the Annelida, Arthropoda, Mollusca, Cnidaria, Nemertea, and Platyhelminthes phyla. Current taxonomy was used for most groups but, in a few cases, older taxonomic names were used for consistency with historical data. Analysis of this dataset indicates that eutrophication, water quality improvement, and dreissenid introduction were the major drivers of changes in the benthic community in the western basin, while hypoxia was a major factor in the central basin, and dreissenid introduction was the most important driver in the eastern basin. Considering the rarity of high taxonomic resolution long‐term benthic data for lake ecosystems, this dataset could be useful to explore broader aspects of ecological theory, including effects of eutrophication, hypoxia, invasive species, and other factors on community organization, phylogenetic and functional diversity, and spatial and temporal scales of variation in community structure. In addition, the dataset could be useful for studies on individual species, including abundance and distribution, species co‐occurrence, and how the patterns of dominance and rarity change over space and time. Use of this dataset for academic or educational purposes is encouraged as long as this data paper is properly cited.
Recent progress of interface modification of layered oxide cathode material for sodium‐ion batteries
Authors: Sun Luyi , Zeng Jun , Wan Xuanhong , Peng Chenxi , Wang Jiarui , Lin Chongjia , Zhu Min , Liu Jun 
Published: April 2024

AbstractWith the advantages of similar theoretical basis to lithium batteries, relatively low budget and the abundance of sodium resources, sodium ion batteries (SIBs) are recognized as the most competitive alternative to lithium‐ion batteries. Among various types of cathodes for SIBs, advantages of high theoretical capacity, nontoxic and facile synthesis are introduced for layered transition metal oxide cathodes and therefore they have attracted huge attention. Nevertheless, layered oxide cathodes suffer from various degradation issues. Among these issues, interface instability including surface residues, phase transitions, loss of active transition metal and oxygen loss takes up the major part of the degradation of layered oxides. These degradation mechanisms usually lead to irreversible structure collapse and cracking generation, which significantly influence the interface stability and electrochemical performance of layered cathodes. This review briefly introduces the background of researches on layered cathodes for SIBs and their basic structure types. Then the origins and effects on layered cathodes of degradation mechanisms are systematically concluded. Finally, we will summarize various interface modification methods including surface engineering, doping modification and electrolyte composition which are aimed to improve interface stability of layered cathodes, perspectives of future research on layered cathodes are mentioned to provide some theoretical proposals.
Spanish consensus on the management of concomitant antiseizure medications when using cenobamate in adults with drug‐resistant focal seizures
Authors: Carreño Mar , Gil‐Nagel Antonio , Serratosa José M. , Toledo Manuel , Rodriguez‐Uranga Juan Jesus , Villanueva Vicente 
Published: April 2024

AbstractObjectiveCenobamate is an antiseizure medication (ASM) associated with high rates of seizure freedom and acceptable tolerability in patients with focal seizures. To achieve the optimal cenobamate dose for maximal potential effectiveness while avoiding or minimizing drug‐related adverse events (AEs), the administration of cenobamate with other ASMs must be managed through concomitant ASM load reduction. A panel of Spanish epilepsy experts aimed to provide a Spanish consensus on how to adjust the dose of concomitant ASMs in patients with drug‐resistant epilepsy (DRE) in order to improve the effectiveness and tolerability of adjunctive cenobamate.MethodsA three‐stage modified Delphi consensus process was undertaken, including six Spanish epileptologists with extensive experience using cenobamate. Based on current literature and their own expert opinion, the expert panel reached a consensus on when and how to adjust the dosage of concomitant ASMs during cenobamate titration.ResultsThe expert panel agreed that tailored titration and close follow‐up are required to achieve the best efficacy and tolerability when initiating cenobamate in patients receiving concomitant ASMs. When concomitant clobazam, phenytoin, phenobarbital, and sodium channel blockers are taken at high dosages, or when the patient is receiving two or more sodium channel blockers, dosages should be proactively lowered during the cenobamate titration period. Other concomitant ASMs should be reduced only if the patient reports a moderate/severe AE at any stage of the titration period.SignificanceCenobamate is an effective ASM with a dose‐dependent effect. To maximize effectiveness while maintaining the best tolerability profile, co‐medication management is needed. The recommendations included herein provide practical guidance for proactive and reactive management of co‐medication in cenobamate‐treated patients with DRE and a high drug load.Plain Language SummaryPatients with epilepsy may continue to have seizures even after treatment with several different antiseizure medications (ASMs). Cenobamate is an ASM that can reduce seizures in these patients. In this study, six Spanish experts in epilepsy discussed the best way to use cenobamate in drug‐resistant epilepsy. They provide practical guidance on when and how the dose of other ASMs might be adjusted to reduce side effects and optimize the use of cenobamate.
Probabilistic risk assessment for reinforced concrete frame structures subject to mainshock‐aftershock sequences
Authors: Zhou Zhou , Lu Dagang , Gardoni Paolo , Han Miao , Yu Xiaohui 
Published: April 2024

AbstractRecent earthquakes have highlighted that aftershocks can considerably increase the structural demand and seismic risk of engineering structures. This study presents a probabilistic approach to assess the seismic risk of reinforced concrete (RC) frame structures subjected to mainshock‐aftershock sequences. In this approach, a predictive fragility method is used to evaluate the probabilities of structural damage under sequential excitations. The Bayes theorem is employed to generate posterior distributions of unknown model parameters. Then, a practical seismic hazard assessment method is used to conduct mainshock‐aftershock hazard analysis. The Copula technique is employed to develop a joint distribution model of the mainshock and aftershock intensity measures. Finally, the seismic risk is evaluated using the classical risk integration equation with the mainshock‐aftershock fragilities and hazard surfaces. Confidence bounds for fragilities and seismic risks are also obtained to account for the uncertainties of model parameters caused by aftershocks. The proposed approach is demonstrated by considering a seismic‐designed RC frame building. It can be concluded that aftershocks can significantly increase the seismic risk throughout the entire structural service life. The additional uncertainties caused by aftershocks result in wider confidence bounds for seismic risk.
Enhanced absorption of prenylated cinnamic acid derivatives from Brazilian green propolis by turmeric in humans and rats
Authors: Yamaga Masayuki , Kawabe Hiroshi , Tani Hiroko , Yamaki Ayanori 
Published: April 2024

AbstractPrenylated cinnamic acid derivatives are the bioactive components of Brazilian green propolis (BGP). The effect of other botanical components on the pharmacokinetic profiles of these derivatives remains relatively unexplored. In the present study, we investigated the influence of several herbal extracts (turmeric, ginkgo leaf, coffee fruit, soybean, and gotu kola) on the plasma concentrations of cinnamic acid derivatives after BGP consumption. When the herbal extracts were co‐administered with BGP in the clinical study, the area under the curve (AUC) values of artepillin C and drupanin, the major BGP components in plasma, were significantly increased by 1.7‐ and 1.5‐fold, respectively, compared to those after BGP administration alone. Among the herbal extracts administered to rats, turmeric extract increased the AUC. Furthermore, a bidirectional transport assay suggested that artepillin C and drupanin are substrates of breast cancer resistance protein (BCRP), a drug elimination transporter. These results suggest that curcumin‐containing turmeric extract may increase the plasma concentrations of artepillin C and drupanin via BCRP. Our findings enabled us to estimate the food–herb and herb–herb interactions in vivo in foods and herbal medicines containing cinnamic acid derivatives and prenylated compounds.
Design toolchain for automotive E/E architecture exploration
Authors: LAURENT Jean‐Baptiste , RICHEFEU Julien , MONSUEZ Bruno 
Published: April 2024

AbstractDesign space exploration (DSE) is an elegant way to tackle the ever‐growing design complexity of automotive Electrical/Electronic (E/E) architectures. In this paper, a toolchain extension is presented and discussed. While still under development, it enhances the modeling with a graphical canvas and allows the model to be defined more naturally, and agnostically before being attached to the rest of the toolchain. It is, then, that more heavy‐duty simulation frameworks such as Metropolis are put to use to perform guided design space exploration and converge toward an optimum.We validated the extended toolchain with a proof of concept use case being challenged by the addition of a third camera, and the way the existing two‐frontal cameras subsystem could be adjusted to fit it best. It is intended for this modeling toolchain to be reusable on a larger range of design use‐cases.
Revisiting Large Scale Defence Acquisition: Uncertainty and Acquisition Responsiveness
Authors: de Haan Peter , Efatmaneshnik Mahmoud , James Ady 
Published: April 2024

AbstractThis article re‐examines the model for large‐scale defence acquisition, aiming to establish a more adaptable framework that can effectively navigate the uncertainties of a dynamic and evolving operational environment. Drawing upon principles derived from Beer's Viable System Model (VSM), coupled with software engineering concepts from DevOps and innovation frameworks, the article proposes the development of a preliminary acquisition framework. The primary objective of this endeavour is to refine the framework, facilitating the creation of naval platforms that possess enhanced future‐proofing capabilities. Simultaneously, the aim is to minimize the time gap between significant acquisition decisions and achieving initial operating capability, all while upholding the fundamental requisites of the prevailing acquisition frameworks. Considering the extended operational lifespan of valuable assets, which can exceed two decades, there is a discernible risk that naval resources might become obsolete due to technological advancements driven by evolving adversarial threats. To counteract this potential scenario, it becomes imperative to regard naval acquisition as a continuous process, necessitating ongoing evolution and timely updates that align with the swiftly changing environmental conditions. This article asserts the significance of embracing a future‐proofing mindset. Such an approach holds the potential to curtail expenses associated with the swift and cost‐effective implementation of new capabilities as we advance into the future.
Environmental and social governance performance and enterprise total factor productivity
Authors: Cheng Zhonghua , Han Lele 
Published: April 2024

AbstractWith the popularity of both green development and sustainable investment concepts, evaluation of environmental performance, social responsibility and corporate governance (ESG) is the way for enterprises to protect the environment and, at the same time, interact with stakeholders. This paper first analyses how ESG influences corporate total factor productivity (TFP), then, using A‐share listed company data from 2009 to 2021, conducts an empirical test proving that ESG greatly boosts TFP. Examination of the intermediate mechanism reveals that ESG can improve TFP by raising R&D investment, enhancing the attention of stakeholders, and increasing internal control capabilities. The heterogeneity study shows that, for state‐owned firms, non‐polluting industries, and small‐scale and low‐market degree enterprises, ESG enhances TFP more. Further analysis indicates that ESG uncertainty and ESG catering behaviour will weaken the fostering impact, but environmental regulation has a beneficial regulatory role.
Intense and problematic social media use and sleep difficulties of adolescents in 40 countries
Authors: Khan Asaduzzaman , Thomas George , Karatela Shamshad , Morawska Alina , Werner‐Seidler Aliza 
Published: April 2024

AbstractIntroductionSocial media has become a ubiquitous part of everyday life; however, evidence suggests patterns of social media use can affect sleep health in children and adolescents. This study aimed to examine the associations of intense and problematic social media use (SMU) with sleep‐onset difficulties in adolescence.MethodsWe analysed data from 212,613 adolescents aged 11‐15 years (51.1% girls) from 40 European and North American countries that participated in the 2017/2018 Health Behaviour in School‐aged Children survey. Intense SMU assessed how often respondents had online contact through social media, and problematic SMU was assessed by symptoms of addiction to social media. Sleep‐onset difficulties were assessed using a self‐reported item. Multilevel mixed‐effects logistic regression was used to obtain the estimates.ResultsSleep‐onset difficulties were more common among girls than boys (27.1% vs 20.8%). Intense SMU was significantly associated with sleep‐onset difficulties in boys in 17 countries and in girls in 25 countries, while problematic SMU was significantly associated in most of the participating countries. Overall, exposure to problematic SMU alone was highly associated with sleep‐onset difficulties both in girls (OR 2.20, 2.04–2.38) and boys (OR 1.88, 1.73–2.04), while the association estimates for intense SMU were smaller and comparable across gender (Girls: OR 1.27, 1.23–1.31; Boys: OR 1.22, 1.18–1.27). Sensitivity analyses supported the above findings.ConclusionsIntense and/or problematic SMU were associated with sleep‐onset difficulties across gender with associations being higher for problematic compared to intense SMU. Prospective research with objective measures is needed to understand the causal mechanisms underlying these relationships.