bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigations into Viomycin Biosynthesis by Using Heterologous Production in Streptomyces lividans
Authors: Barkei John J. , Kevany Brian M. , Felnagle Elizabeth A. , Thomas Michael G. 
Published: December 2008

AbstractViomycin and capreomycin are members of the tuberactinomycin family of antituberculosis drugs. As with many antibacterial drugs, resistance to the tuberactinomycins is problematic in treating tuberculosis; this makes the development of new derivatives of these antibiotics to combat this resistance of utmost importance. To take steps towards developing new derivatives of this family of antibiotics, we have focused our efforts on understanding how these antibiotics are biosynthesized by the producing bacteria so that metabolic engineering of these pathways can be used to generate desired derivatives. Here we present the heterologous production of viomycin in Streptomyces lividans 1326 and the use of targeted‐gene deletion as a mechanism for investigating viomycin biosynthesis as well as the generation of viomycin derivatives. Deletion of vioQ resulted in nonhydroxylated derivatives of viomycin, while strains lacking vioP failed to acylate the cyclic pentapeptide core of viomycin with β‐lysine. Surprisingly, strains lacking vioL produced derivatives that had the carbamoyl group of viomycin replaced by an acetyl group. Additionally, the acetylated viomycin derivatives were produced at very low levels. These two observations suggested that the carbamoyl group of the cyclic pentapeptide core of viomycin was introduced at an earlier step in the biosynthetic pathway than previously proposed. We present biochemical evidence that the carbamoyl group is added to the β‐amino group of L‐2,3‐diaminopropionate prior to incorporation of this amino acid by the nonribosomal peptide synthetases that form the cyclic pentapeptide cores of both viomycin and capreomycin.
Tiered mentoring to leverage student body expertise
Authors: Jaswal Faisal , Jaswal Teresa McClane 
Published: December 2008

AbstractThis chapter presents an overview of a new tiered mentoring program operating at Bellevue Community College in Washington. The program links students with peers, faculty, staff, and administrators via a tiered structure whereby first‐year students are mentored by upper‐level students, who in turn are mentored by professionals in the students' field of study.
Acute stroke intervention by interventional cardiologists
Authors: DeVries James T. , White Christopher J. , Collins Tyrone J. , Jenkins J. Stephen , Reilly John P. , Grise Mark A. , McMullan Paul W. , Badawi Ramy A. , Ramee Stephen R. 
Published: December 2008

AbstractObjectives:To report the technical success and clinical outcomes of catheter‐based therapy (CBT) for acute ischemic stroke in patients ineligible for intravenous thrombolysis.Background:Acute ischemic stroke is common but undertreated. CBT for acute ischemic stroke is a therapeutic option in selected patients who are not candidates for intravenous thrombolysis.Methods:Consecutive stroke patients who were ineligible for intravenous thrombolysis and underwent CBT were identified by retrospective chart review. Demographic information, National Institutes of Health Stroke Scale (NIHSS), procedural characteristics, and clinical outcomes during hospitalization and at 90 days follow up were collected. Experienced interventional cardiologists with the consultative support of stroke neurologists were on call for acute strokes.Results:A total of 33 acute ischemic stroke patients underwent emergency cerebral angiography, with 26 patients undergoing CBT. Successful “culprit” artery recanalization was achieved in 23 (88%) of the 26 patients. In‐hospital adverse events occurred in 4 (15%) patients, with intracerebral hemorrhage (ICH) (12%) representing the most common adverse event. The baseline NIHSS for patients who underwent intervention was 16.5 ± 9.9 (median 16) and improved significantly to 9.9 ± 8.7 (median 9) (P < 0.001) at hospital discharge. A modified Rankin score of two or less (indicating mild disability) was achieved in half (n = 13) of the CBT treated patients. All cause mortality at 90 days was 8% (2/26).Conclusions:In selected patients, CBT provided by qualified interventional cardiologists supported by stroke neurologists, offers a safe and effective option for patients with acute stroke who are not eligible for intravenous thrombolysis. © 2008 Wiley‐Liss, Inc.
Fracture of the GORE HELEX septal occluder: Associated factors and clinical outcomes
Authors: Fagan Thomas , Dreher Dennis , Cutright Warren , Jacobson Joth , Latson Larry 
Published: December 2008

AbstractObjectives:This study examines factors associated with, and clinical effects of, wire frame fractures (WFF) of the GORE HELEX™ Septal Occluder (HELEX).Methods:Investigator‐reported data from every HELEX implanted in the United States between 4/2000 and 4/2005 were reviewed. Clinical and procedural data from patients who experienced WFF were compared with data from patients who did not. The echocardiographic and fluoroscopic images for HELEX with WFF were reviewed for predictors of WFF and alterations in HELEX function.Results:With 90% of subjects followed for >12 months, 19/298 (6.4%) HELEX implanted were found to have WFF. Thirty WFFs were observed, with multiple WFFs occurring in 8/19 HELEX. Univariate predictors of WFF were large device size (P = 0.0003) and balloon defect size (P = 0.001); however, large device size (P = 0.0003) was the only significant predictor of WFF by multivariate analysis. WFF of the 30‐mm and 35‐mm HELEX accounted for 84% (16/19) of all WFFs. Review of HELEX images with WFF revealed all WFF occurred along the circumferential wire, except one (straight portion of locking loop). Seventeen of 29 (59%) circumferential WFFs were on the right disk. Residual defect status remained clinically insignificant (6/19) or became completely occluded (13/19) during follow‐up. There were no clinical sequelae due to WFF; however, secondary to right atrial disk mobility, the HELEX with locking loop WFF was percutaneously removed 6 weeks after implantation.Conclusions:WFF occurred in 6.4% of HELEX and were most common in large devices. With the exception of one device removed for theoretical risks, no clinical sequelae were related to WFF. WFF did not alter the function of the HELEX. © 2008 Wiley‐Liss, Inc.
Venting of Foaming Three‐Phase Systems
Authors: Poli M. , Imhof H. , Holst N. , Steinbach J. 
Published: December 2008

AbstractDesigning pressure relief devices for three‐phase systems consisting of solids, liquids and vapors requires an in‐depth knowledge of the fluid dynamics and of the thermodynamic effects in the reactor. The behavior of foaming three‐phase systems is, to date, still not well understood. In this research, these systems are systematically studied, taking the solid properties into account. Also, the applicability of two‐phase pressure relief models to three‐phase systems is investigated with the help of the simulation tool SAFIRE/Vent. The results obtained contribute significantly to the better design of pressure relief devices and to more accurate predictions of the three‐phase venting behavior and the solid discharge.
ICE: a new method for the multivariate curve resolution of hyperspectral images
Authors: Berman Mark , Phatak Aloke , Lagerstrom Ryan , Wood Bayden R. 
Published: December 2008

AbstractThe iterated constrained endmembers (ICE) algorithm is a new method of unmixing hyperspectral images that combines aspects of multivariate curve resolution (MCR) methods in chemometrics and unmixing algorithms in remote sensing. Like many MCR methods, ICE also estimates pure components, or endmembers, via alternating least squares; however, it is explicitly based on a convex geometry model and estimation is carried out in a subspace of reduced dimensionality defined by the minimum noise fraction (MNF) transform. In this paper, we describe the ICE algorithm and its properties. We also illustrate its use on a hyperspectral image of cervical tissue. The unmixing of hyperspectral images presents some unique challenges, and we also outline where further development is required. © 2008 John Wiley & Sons, Ltd.
ChemInform Abstract: Single Crystal Investigation of Tb3Cu4Sn4 and Dy3Cu4Sn4 Stannides with Gd3Cu4Ge4‐Type Structure.
Authors: Romaka V. , Pavlyuk V. , Marciniak B. , Tkachuk A. 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Large Enhancements in the Thermoelectric Power Factor of Bulk PbTe at High Temperature by Synergistic Nanostructuring.
Authors: Sootsman Joseph R. , Kong Huijun , Uher Ctirad , D'Angelo Jonathan James , Wu Chun‐I , Hogan Timothy P. , Caillat Thierry , Kanatzidis Mercouri G. 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hexagonal YFe1‐xPdxO3‐δ: Nonperovskite Host Compounds for Pd2+ and Their Catalytic Activity for CO Oxidation.
Authors: Li Jun , Singh Udayshankar G. , Schladt Thomas D. , Stalick Judith K. , Scott Susannah L. , Seshadri Ram 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structural Evolution of “S”‐Shaped [H4W22O74]12‐ and “”‐Shaped [H10W34O116]18‐ Isopolyoxotungstate Clusters.
Authors: Miras Haralampos N. , Yan Jun , Long De‐Liang , Cronin Leroy 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Crystal Structure, Bonding, and Properties of (Ba6O)(OsN3)2.
Authors: Schmidt Carsten L. , Wedig Ulrich , Dinnebier Robert , Jansen Martin 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iron‐Catalyzed Hydroxylation of β‐Ketoesters with Hydrogen Peroxide as Oxidant.
Authors: Li Dongmei , Schroeder Kristin , Bitterlich Bianca , Tse Man Kin , Beller Matthias 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Conjugate Addition of Cyanide to Enones: Cooperative Catalysis of Ni(0) and Gd(OTf)3.
Authors: Tanaka Yuta , Kanai Motomu , Shibasaki Masakatsu 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mono‐Acylation of Symmetric Diamines in the Presence of Water.
Authors: Tang Wei , Fang Shiyue 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Rapid Access to New Fluorinated 1,3‐Dienes and Benzylic Fluorides via Metathesis on Propargylic Fluorides.
Authors: Pujari Sandip A. , Kaliappan Krishna P. , Valleix Alain , Gree Danielle , Gree Rene 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Primary‐Amine‐Catalyzed Enantioselective Intramolecular Aldolizations.
Authors: Zhou Jian , Wakchaure Vijay , Kraft Philip , List Benjamin 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: (S)‐Pyrrolidin‐2‐ylmethyl‐1,2,3‐triazolium Salts — Ionic Liquid Supported Organocatalysts for Enantioselective Michael Additions to β‐Nitrostyrenes.
Authors: Yacob Zekarias , Shah Jabbar , Leistner Joachim , Liebscher Juergen 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recyclable Polyisobutylene‐Supported Pyridyl N‐Oxide Allylation Catalysts.
Authors: Bergbreiter David E. , Ortiz‐Acosta Denisse 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: First Example of Continuous‐Flow Reaction Conditions for Biomimetic Reductive Amination of Fluorine‐Containing Carbonyl Compounds.
Authors: Soloshonok Vadim A. , Ono Taizo 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Synthesis of Functionalized 3‐(Methylthio)phenols by the First Formal [3 + 3] Cyclocondensations of 1,3‐Bis(trimethylsilyloxy)‐1,3‐butadienes with 1,1‐Bis(methylthio)‐1‐en‐3‐ones.
Authors: Lubbe Mathias , Klassen Renske , Trabhardt Tiana , Villinger Alexander , Langer Peter 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Novel Cyclopentenone Derivatives and Crystal Structure Determination of 3,4‐Bis(4‐chlorophenyl)‐5,5‐dimethyl‐4‐hydroxy‐2‐cyclopenten‐1‐one.
Authors: Marjani Katayoun , Mousavi Mohsen , Ashouri Akram , Arazi Omid , Bourghani Samira , Asgari Maryam 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Cytotoxic Activity of Some Novel Polycyclic γ‐Butyrolactones.
Authors: Ishar M. P. S. , Raj Tilak , Agrawal Satyam Kumar , Saxena A. K. , Singh Lakhwinder , Singh Rajinder , Bhella Surinderjit Singh 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: General Strategy for the Synthesis of Natural and Unnatural Dialkylmaleic Anhydrides.
Authors: Haval Kishan P. , Argade Narshinha P. 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Intramolecular Hydroarylation of Alkenes via Directed C—H Bond Activation.
Authors: Harada Hitoshi , Thalji Reema K. , Bergman Robert G. , Ellman Jonathan A. 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Mild and Versatile Synthesis of Bis(indolyl)methanes and Tris(indolyl)alkanes Catalyzed by Antimony Trichloride.
Authors: Kundu Pradip , Maiti Gourhari 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photocycloaddition of 5‐Methoxyoxazoles to Aldehydes and α‐Keto Esters: A Comprehensive View on Stereoselectivity, Triplet Biradical Conformations, and Synthetic Applications of Paterno—Buechi Adducts.
Authors: Griesbeck Axel G. , Bondock Samir 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diaziridine Ring Expansion in 6‐Aryl‐1,5‐Diazabicyclo[3.1.0]hexanes on Treatment with Nitriles Assisted by Ionic Liquids.
Authors: Syroeshkina Yuliya S. , Kuznetsov Vladimir V. , Struchkova Marina I. , Epishina Margarita A. , Makhova Nina N. 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Three‐Component Coupling of Aldehydes, Homoallyl Alcohols, and Trimethylsilyl Azide: A Facile Synthesis of 4‐Azidotetrahydropyrans via the Prins Cyclization.
Authors: Yadav Jhillu S. , Reddy Basi V. Subba , Maity Tapas , Kumar Gunda G. K. S. Narayana 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Antibacterial Activity of 6‐(5‐Phenyl‐[1,3,4]thiadiazol‐2‐ylamino)‐benzopyran‐2‐ones.
Authors: Mayekar Sagar A. , Mulwad Vinata V. 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 14‐Aryl‐14H‐dibenzo[a,j]xanthene Derivatives Catalyzed by Expanded Graphite under Solvent‐Free Condition.
Authors: Li Geng‐Chen 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Povarov Reaction of Ethyl (18‐Carbomethoxyabieta‐8,11,13‐triene‐12‐imino)glyoxylate with Electron‐Donating Dienophiles.
Authors: Tarantin Alexey V. , Glushkov Vladimir A. , Mayorova Olga A. , Shcherbinina Irina A. , Tolstikov Alexander G. 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Three‐Component Synthesis of Fluorinated Pyrimidine Carbonitrile Derivatives under Thermal Aqueous Conditions.
Authors: Sheibani Hassan , Saidi Kazem , Saljooghi Arman S. 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Iodoreboxetine Analogues for SPECT Imaging of the Noradrenaline Transporter.
Authors: Jobson Nicola K. , Crawford Andrew R. , Dewar Deborah , Pimlott Sally L. , Sutherland Andrew 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1,3‐Dipolar Cycloaddition Reactions Initiated with the 1,5‐Dimethyl‐3‐phenyl‐6‐oxoverdazyl Radical.
Authors: Yang Angela , Kasahara Takahito , Chen Eric K. Y. , Hamer Gordon K. , Georges Michael K. 
Published: December 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.