bluuebunny/crossref_metadata_2025_split huggingface dataset:
A phenomenological study of spirituality and learning processes at work: Exploring the holistic theory of knowledge and learning
Authors: Gallagher Suzanne J. , Rocco Tonette S. , Landorf Hilary 
Published: November 2007

AbstractThe holistic theory of knowledge and learning offers an integrative framework for understanding the interactions of cognitions, feelings, and behavior in learning. Explicit (cognitions), implicit ( behavior), and emancipatory (feelings, values, spirituality) knowledge facets interact in learning processes. Little is known, however, about the nature of these interactions and the role of spirituality in learning. A phenomenological study of professionals' learning processes at work showed that knowledge facets interact in learning through expressing, informing, changing, and guiding one another. Complex interactions within knowledge facets were identified as well as the dangers of learning using only one knowledge facet. The essential role of community in learning processes was affirmed, and the guiding, informing role of spirituality in learning at work was revealed.
Serous ovarian, fallopian tube and primary peritoneal cancers: A comparative epidemiological analysis
Authors: Jordan Susan J. , Green Adèle C. , Whiteman David C. , Moore Suzanne P. , Bain Christopher J. , Gertig Dorota M. , Webb Penelope M. ,   for the Australian Cancer Study Group (ovarian cancer) and the Australian Ovarian Cancer Study Group
Published: November 2007

AbstractInvasive serous cancers are diagnosed in the ovary, fallopian tube and peritoneum. It is widely believed that these are variants of the same malignancy but little is known about fallopian tube and primary peritoneal cancers. A comparison of risk factors for these tumor types may shed light on common or distinct aetiological pathways involved in these types of cancer. We investigated risk factors for the three cancers using data from a large Australian population‐based case‐control study. We included women with incident invasive serous ovarian (n = 627), primary peritoneal (n = 129) and fallopian tube (n = 45) cancer and 1,508 control women. Participants completed a comprehensive reproductive and lifestyle questionnaire. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Hormonal contraceptive use was inversely related to risk of all three cancers. Parity and breast‐feeding were also inversely related to risk of serous ovarian and fallopian tube cancer. In contrast, parous women had an increased risk of peritoneal cancer (OR = 1.8, 95%CI 0.8–3.9), and increasing parity did not lower risk. There was also no association between breast‐feeding and peritoneal cancer. However, obesity was associated with a doubling of risk for peritoneal cancer alone (OR = 2.1, 95%CI = 1.3–3.4). The strikingly similar patterns of risk for serous ovarian and fallopian tube cancers and the somewhat different results for primary peritoneal cancer suggest that peritoneal cancers may develop along a different pathway. These results also call into question the role of the physical effects of ovulation in the development of serous ovarian cancer. © 2007 Wiley‐Liss, Inc.
Raman spectroscopic study of serum albumins: an effect of proton‐ and γ‐irradiation
Authors: Synytsya Alla , Alexa Petr , de Boer Jorrit , Loewe Markus , Moosburger Martin , Würkner Michael , Volka Karel 
Published: November 2007

AbstractRaman spectroscopy was applied to analyse structural changes in serum albumins (bovine serum albumin, BSA; human serum albumin, HSA) following proton and γ‐irradiation (0.5, 5 and 50 Gy). Characteristic Raman bands of both polypeptide backbone and amino acid residues were sensitive to irradiation. Significant damage of HSA/BSA was observed only at the highest dose (50 Gy). Raman spectra confirmed radiation‐induced denaturation, destruction of helical structures and aggregation of serum albumins. The differences in the dose‐dependent effects of proton and γ‐radiation on studied proteins are discussed. Copyright © 2007 John Wiley & Sons, Ltd.
Aberrant expression and localization of connexin43 and connexin30 in a rat glioma cell line
Authors: Mennecier Grégory , Derangeon Mickaël , Coronas Valérie , Hervé Jean‐Claude , Mesnil Marc 
Published: November 2007

AbstractGap junctions are cellular structures which permit direct exchanges of small molecules from cytoplasm to cytoplasm in most of the cells of metazoan organisms. For four decades, it has been observed that the inhibition of this type of intercellular communication is often associated with tumorigenesis. The assumption that loss of homeostasis which characterizes tumor growth could be a consequence of a lack of gap junctional intercellular communication (GJIC) has been reinforced by strategies able to reinduce both GJIC and normalization of the phenotype. So far, no molecular data may explain clearly how gap junctions can regulate cell proliferation. It has been argued that the gap‐junction tumor suppressive effect may depend specifically on the connexin type which is expressed. For instance, the transfection of connexin30 (Cx30), a gap junction protein, has been previously associated with a slower growth of rat glioma cells (9L cells). Here, we show that these cells do communicate less compared to the Cx43‐expressing parental cells even if the Cx30‐transfected cells do express more Cx43. This result was related to the cytoplasmic distribution of Cx43 and a nuclear localization of both the Cx30 and a 20‐kDa fragment corresponding to a Cx43 signal. According to these data, it seems that cell growth regulation may depend more on the behavior of connexins than the simple establishment of GJIC. © 2007 Wiley‐Liss, Inc.
Identification of polymorphisms in the Caspase‐3 gene and their association with lung cancer risk
Authors: Jang Jin Sung , Kim Kyung Mee , Choi Jin Eun , Cha Sung Ick , Kim Chang Ho , Lee Won Kee , Kam Sin , Jung Tae Hoon , Park Jae Yong 
Published: November 2007

AbstractCaspase‐3 (CASP‐3) is a primary effector CASP that executes programmed cell death, and it plays an important role in the development and progression of cancer. Polymorphisms in the CASP‐3 gene may influence CASP‐3 production and/or activity, thereby modulating the susceptibility to lung cancer. To test this hypothesis, we first screened for polymorphisms in the CASP‐3 gene by direct sequencing of genomic DNA samples from 27 healthy Koreans, and then evaluated their associations with lung cancer in a case–control study that consisted of 582 lung cancer patients and 582 healthy controls. Individuals with at least one variant allele of the −928A > G, 77G > A, and 17532A > C polymorphisms were at a significantly decreased risk for lung cancer in comparison to the carriers with each homozygous wild‐type allele [adjusted odds ratio (OR) = 0.79, 95% confidence interval (CI) = 0.62–1.00, P = 0.05; adjusted OR = 0.78, 95% CI = 0.61–0.99, P = 0.04; and adjusted OR = 0.74, 95% CI = 0.58–0.95, P = 0.02, respectively]. Consistent with the results of genotyping analysis, the GAGC haplotype carrying the variant allele at all of the −928A > G, 77G > A, and 17532A > C loci was associated with a significantly decreased risk of lung cancer compared to the AGGA haplotype carrying no variant alleles at the three loci (adjusted OR = 0.66, 95% CI = 0.51–0.86, P = 0.002 and Bonferroni corrected P = 0.008). These results suggest that the CASP‐3 polymorphisms and their haplotypes contribute to the genetic susceptibility to lung cancer. © 2007 Wiley‐Liss, Inc.
Modified expression of cytoplasmic isocitrate dehydrogenase electrophoretic isoforms in seminal plasma of men with sertoli‐cell‐only syndrome and seminoma
Authors: Starita‐Geribaldi Mireille , Samson Michel , Guigonis Jean‐Marie , Pointis Georges , Fenichel Patrick 
Published: November 2007

AbstractTwo isoforms of human cytoplasmic isocitrate dehydrogenase (IDPc) of close molecular weights and different isoelectric points were identified in human seminal plasma (SP) by two‐dimensional gel electrophoresis (2‐DE) followed by mass spectrometry (MS). These two isoforms were detected in the normospermic men SP and their expressions were markedly altered in patients with testicular seminoma, the most frequent testicular germ cell cancer (TGCC): increase of the more acidic spot and decrease of the more basic one. Since oligospermia has been considered as a high risk pathological condition for developing a testicular cancer, the two IDPc isoforms were analyzed in SP of a group of secretory azoospermic patients. In this group the two spots displayed similar variations of expression to those observed in testicular seminoma. These results propose IDPc as a promising SP biomarker of testicular seminoma. Whether IDPc alteration in secretory azoospermia is predictive of testicular seminoma remains to be elucidated. © 2007 Wiley‐Liss, Inc.
Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome
Authors: Winkelmann Juliane , Lichtner Peter , Schormair Barbara , Uhr Manfred , Hauk Stephanie , Stiasny‐Kolster Karin , Trenkwalder Claudia , Paulus Walter , Peglau Ines , Eisensehr Ilonka , Illig Thomas , Wichmann H.‐Erich , Pfister Hildegard , Golic Jelena , Bettecken Thomas , Pütz Benno , Holsboer Florian , Meitinger Thomas , Müller‐Myhsok Bertram 
Published: November 2007

AbstractSixty percent of the patients with restless legs syndrome (RLS) report a positive family history. To date five loci have been mapped on chromosome 12q, 14q, 9p, 2q, and 20p (RLS1‐5) but no gene has been identified so far. To identify genes related to RLS, we performed a three‐stage association study (explorative study, replication study, high‐density mapping) in two Caucasian RLS case‐control samples of altogether 918 independent cases and controls. In the explorative study (367 cases and controls, respectively), we screened 1536 SNPs in 366 genes in a 21 Mb region encompassing the RLS1 critical region on chromosome 12. Armitage trend test revealed three genomic regions that were significant (P < 0.05). In the replication study (551 cases and controls, respectively) we genotyped the most significant SNPs of Stage 1. After correction for multiple testing, association was observed with SNP rs7977109 (Pnominal = 0.00175, PWestfall‐Young = 0.04895, OR = 0.76228, 95% CI = 0.64310–0.90355), which is in the neuronal nitric oxide synthase (NOS1) gene. High‐density mapping using altogether 34 tagging and coding SNPs of the NOS1 gene in both case‐control samples further confirmed the significant association results to NOS1. Ten more SNPs revealed significance with nominal P‐values from 0.0001 to 0.0482 (genotypic test and Armitage test). Altogether, this study provides evidence for an association of variants in the NOS1 gene and RLS, and suggests the involvement of the NO/arginine pathway in the pathogenesis of RLS. Potential usage of NO modulating agents as new treatment options for RLS have become a challenging aspect for future research of this disorder. © 2007 Movement Disorder Society
Messenger RNA expression patterns of histone‐associated genes in bovine preimplantation embryos derived from different origins
Authors: Nowak‐Imialek Monika , Wrenzycki Christine , Herrmann Doris , Lucas‐Hahn Andrea , Lagutina Irina , Lemme Erika , Lazzari Giovanna , Galli Cesare , Niemann Heiner 
Published: November 2007

AbstractHistone modification genes in bovine embryos: The mRNA expression pattern of histone‐related genes was determined in bovine oocytes and embryos. We compared immature and in vitro‐matured oocytes, either before or after enucleation and activation, in vitro produced embryos (zygotes, 8–16 cell stages, blastocysts), embryos cloned with female or male donor cells; parthenogenetic embryos, and in vivo‐derived blastocysts to detect deviations from the normal expression pattern. A sensitive semi‐quantitative endpoint RT‐PCR assay was used to reveal differences in histone deacetylation [histone deacetylase 2 (HDAC2)]; histone acetylation [histone acetyltransferase 1 (HAT1)]; histone methylation [histone methyltransferases (SUV39H1, G9A)]; heterochromatin formation [heterochromatin protein 1 (HP1)]; and chromatin‐mediated transcription regulation [zygote arrest 1 (ZAR1)]. With the exception of ZAR1, these mRNAs were present throughout preimplantation development. The relative abundance of mRNAs for histone methyltransferases (SUV39H1 and G9A) and for heterochromatin‐associated protein (HP1) differed significantly before and after activation of the bovine embryonic genome. The similarity of HAT1 gene expression in 8–16 cell embryos and blastocysts suggests that histone acetylation is primarily affected by in vitro culture only prior to embryonic genome activation. HDAC2 gene mRNA expression was not affected by in vitro culture and/or cloning before and after activation of the embryonic genome. The donor cell line affected mRNA expression patterns of genes involved in reprogramming cloned embryos suggesting epigenetic dysregulation. Results show that both in vitro production and somatic cloning alter the mRNA expression of histone modifying genes in bovine embryos. Mol. Reprod. Dev. 75: 731–743, 2008. © 2007 Wiley‐Liss, Inc.
Shape optimization of one‐chamber perforated plug/non‐plug mufflers by simulated annealing method
Authors: Chang Ying‐Chun , Chiu Min‐Chie 
Published: November 2007

AbstractTo economically and efficiently lower the venting noise, the development of a high‐quality muffler with compact volume has become crucial in the modern industrial field. The research work of shape optimization of straight silencers in conjunction with plug/non‐plug perforated ducts which may noticeably increase the acoustical performance is rarely addressed; therefore, the main purpose of this paper is not only to analyze the sound transmission loss (STL) of a one‐chamber plug/non‐plug perforated muffler but also to optimize the best design shape under a limited space. In this paper, on the basis of plane wave theory, the four‐pole system matrix in evaluating the acoustic performance is derived by using the decoupled numerical method. Moreover, a simulated annealing (SA) algorithm searching for the global optimum by imitating the softening process of metal has been adopted during the muffler's optimization. To assure SA's correctness, the STL's maximization of one‐chamber perforated plug mufflers at a targeted frequency of 500 Hz is exemplified first. Furthermore, a numerical case in dealing with a broadband noise emitted from a fan by using one‐chamber plug/non‐plug mufflers has been introduced and fully discussed. To achieve a better optimization in SA, various SA parameter sets of cooling rate and iteration parameter values were used. Before the SA operation can be carried out, the accuracy check of the mathematical models with respect to plug/non‐plug perforated mufflers has to be supported by experimental data. The optimal result in eliminating broadband noise reveals that the muffler with a plug acoustical mechanism has a better noise reduction than that of a non‐plug muffler. Consequently, the approach used for the optimal design of the noise elimination proposed in this study is certainly easy, economical, and quite effective. Copyright © 2007 John Wiley & Sons, Ltd.
Synthesis of Heteroleptic Cerium(IV) Complexes Using a Heptadentate (N4O3) Tripodale Schiff‐base Ligand
Authors: Dröse Peter , Gottfriedsen Jochen 
Published: November 2007

AbstractThe Cerium(IV) complexes [{N[CH2CH2N=CH(2‐O‐3,5‐tBu2C6H2)]3}CeCl] (1) and [{N[CH2CH2N=CH(2‐O‐3,5‐tBu2C6H2)]3}Ce(NO3)] (2) were derived from the condensation of tris(2‐aminoethyl)amine and 3,5‐di‐tert‐butylsalicylaldehyde and the appropriate Ce starting material CeCl3(H2O)6 and (NH4)2[Ce(NO3)6], respectively. Single crystal X‐ray diffraction studies reveal monomeric complexes.
Dinuclear Manganese(II) Complexes with Bridging Selenidodiarsenate Anions [As2Se4]4−, [As2Se5]4− and [As2Se6]2−
Authors: Kromm Anna , Sheldrick William S. 
Published: November 2007

AbstractSolvothermal reaction of [MnCl2(amine)] (amine = terpy and tren) with elemental As and Se at a 1:1:2 molar ratio in H2O/tren (10:1) affords the dimanganese(II) complexes [{Mn(terpy)}2(μ‐As2Se4)] (1) and [{Mn(tren)}2(μ‐As2Se5)] (2) respectively. The tetradentate [As2Se4]4− bridging ligands in 1 contain a central As–As bond and exhibit approximately C2h symmetry. Pairs of gauche sited Se atoms participate in five‐membered As2Se2Mn chelate rings. In contrast, two AsSe3 pyramids share a common corner in the [As2Se5]4− ligands of 2 and each coordinates an [Mn(tren)]2+ fragment through a single terminal Se atom. Such dinuclear complexes are linked into tetranuclear moieties through weak Se···Mn interactions of length 3.026(3) Å involving one of these terminal Se atoms. At a 1:3:6 molar ratio, solvothermal reaction of [MnCl2(tren)] with As and Se leads to formation of a second dinuclear complex [{Mn(tren)}2(μ‐As2Se6)2] (3), which contains two bridging bidentate [As2Se6]2− ligands. These are cyclic with an As2Se4 ring and can be regarded as being derived from [As2Se5]4− anions by formation of two Se‐Se bonds to an additional Se atom.
Synthesis, Crystal Structures and Magnetic Properties of Copper(II) Complexes with Nitronyl Nitroxide Radicals
Authors: Wang Yu‐Fang , Wang Li‐Ya , Ma Lu‐Fang 
Published: November 2007

AbstractTwo new copper(II) compounds with imino nitroxide radicals [Cu(IM‐MeImz)2 · (SCN)] 0.5[Cu(SCN)4] (1) and [Cu(IM‐MeImz)2 · (SCN)]ClO4 · H2O (2) (IM‐meImz = 2‐(5‐methylimidazol‐4‐yl)‐4,4,5,5‐tetramethyl‐2‐imidazoline‐1‐oxyl) have been synthesized and characterized structurally and magnetically. X‐ray analysis demonstrates that complex 1 contains CuII ions in both square‐pyramidal and square planar coordination. There are complete charge separation into [Cu(IM‐MeImz)2(SCN)]+ cations and 0.5[Cu(SCN)4]− anions, in a 2:1 ratio. The complex 1 was connected as a one‐dimensional polymer by intermolecular interactions. In complex 2, the coordination around the copper atom is distorted square pyramidal and the apical position is occupied by one nitrogen atom of SCN− anion. The 2‐D network structure was formed and arranged through intermolecular H‐bonds interactions. The complex 1 exhibits intramolecular weak ferromagnetic coupling between CuII ion and the radicals.
Gerüstverbindungen mit beweglichen LaIII‐Kationen: Synthesen, Kristallstrukturen und Strukturdynamik der Lanthan(III)‐Eisen(II)‐Sulfid‐Halogenide La53Fe12S90X3 (X = Cl, Br, I)
Authors: Bräunling Daniel , Leoni Stefano , Mills Allison M. , Ruck Michael 
Published: November 2007

AbstractFramework Compounds with Mobile LaIII Cations: Syntheses, Crystal Structures and Structural Dynamics of the Lanthanum(III) Iron(II) Sulfide Halides La53Fe12S90X3 (X = Cl, Br, I)Black crystals of La53Fe12S90X3 (X = Cl, Br, I) were synthesized from La2S3 and FeS in a reactive LaX3 flux at 1320 K. The structures were determined by single‐crystal X‐ray diffraction. The compounds are isostructural, crystallizing in the rhombohedral space group $R{\bar 3}m$ with Z = 1 (La53Fe12S90Cl3: a = 14.0154(7), c = 21.888(1) Å, V = 3723.5(3) Å3; La53Fe12S90Br3: a = 14.0048(9), c = 22.040(2) Å, V = 3743.6(4) Å3; La53Fe12S90I3: a = 13.9805(8), c = 22.108(2) Å, V = 3742.2(4) Å3). The structure adopted is a stuffed variant of the La52Fe12S90 structure type. [FeII2S9] dimers of face‐sharing octahedra are linked by face‐ and vertex‐sharing bi‐ or tri‐capped [LaIIIS6+n] trigonal prisms, forming a three‐dimensional framework containing cuboctahedral cavities of two sizes. The larger cavities, which remain empty in the structure of La52Fe12S90, are filled by halide ions in La53Fe12S90X3. The smaller cavities accommodate numerous sites for disordered lanthanum cations, modelling a network of diffusion pathways through the structure. An analogous picture is obtained from the calculation of the periodic nodal surface (PNS): The PNS separates a labyrinth containing the framework atoms from a labyrinth containing the mobile lanthanum cations. Molecular dynamic simulations confirm a strong coupling between the motions of the mobile lanthanum ions and the neighbouring sulfide ions.
The Use of an Innovative Device for Wound Closure after Upper Extremity Fasciotomy
Authors: Medina Carlos , Spears Julia , Mitra Amitabha 
Published: November 2007

Introduction The purpose of this paper is to evaluate the Silver Bullet Wound Closure Device (SBWCD, Boehringer Laboratories, Norristown, PA), a new device for delayed primary closure of fasciotomy wounds. Materials and Methods A retrospective review was performed over a period of 36 months of all patients with an upper extremity fasciotomy that could not be closed primarily. Cases that underwent fasciotomy closure with the SBWCD were separated from the patients that had a split thickness skin graft (STSG). Results Seven patients had their wound closed with the SBWCD within 10 days (mean of 7.4 days). The seven patients that underwent STSG had their wound closed in an average of 8.4 days. The average number of days between the day of the fasciotomy incision and the date of the placement of the SBWCD was 1.9 days. STSGs were placed on the fasciotomy wounds on an average of 10.3 days after the date of the fasciotomy incision. We found that the SBWCD allowed for starting to approximate the edges of the fasciotomy wound at an earlier time when compare to STSG (2.1 vs 10.3 days). Conclusions We feel that the SBWCD as a one-stage procedure provides a consistent and efficacious way to manage upper extremity fasciotomy wounds while minimizing the morbidity associated with STSG. Elimination of a second-stage procedure reduces hospital costs. Our findings may help to inform surgeons about an available alternative when an upper extremity fasciotomy wound is not amenable to primary closure.
The influence of nitrous oxide anaesthetic on middle-ear fluid
Authors: Shaw James O. , Stark Earl W. , Gannaway Stephen D. 
Published: November 2007

AbstractNITROUS OXIDE anaesthesia invades the middle-ear cavity, resulting in a positive pressure within this cavity. It has been suggested that the pressure may be sufficient to force open the Eustachian tube and evacuate fluid from the middle ear. This study examined the possible influence of nitrous oxide on middle-ear fluid. Pre- and intra-operative tympanograms were obtained on 39 children scheduled for myringotomy surgery. Fluid was found in 83-1 per cent of the operated ears while the absence of fluid was noted in 16-9 per cent. It is possible that the nitrous oxide anaesthetic did cause an evacuation of fluid from this latter group of ears prior to actual surgery.
Mucocele of the petrous apex
Authors: DeLozier H. L. , Parkins C. W. , Gacek R. R. 
Published: November 2007

AbstractThe first case of a primary mucocele of the petrous apex is presented and the differential diagnosis is briefly discussed. Since this area is unavailable for direct examination, a thorough radiographic evaluation is essential. A mucocele should be suspected when a lytic lesion has a multiloculated appearance and when the contralateral petrous apex is highly pneumatized. Even then, a biopsy may still be needed to make a definitive diagnosis. The appropriate treatment for these cystic lesions is fistulization into a radical mastoid cavity or an exteriorized sphenoid sinus.
The radioallergosorbent test (RAST) in nasal polyposis
Authors: John A.C. , Merrett T. G. 
Published: November 2007

SummaryThe incidence of atopy among 64 adults undergoing polypectomy was 25 per cent. Among these atopic patients it was usual for the polyp IgE level to exceed that in the serum. Similarly,D. pteronyssinus-specific IgE was more commonly identified in polyp fluid by the RAST technique than in serum. However, this was not so for grass poolen-specific IgE, where serum and polyp fluid were equally positive. We conclude that there are atopic and non-atopic polyps.