bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of resection boundaries depending on the defect elimination method in oral mucosal cancer
Authors: Musin Sh. I. , Menshikov K. V. , Sultanbayev A. V. , Sharifgaleev I. A. , Ilyin V. V. , Guz A. O. , Rudyk A. N. , Osokin S. V. , Sharafutdinova N. A. , Chashchin A. V. , Garev A. V. , Baymuratov T. R. 
Published: April 2024

Introduction. Surgical intervention remains the main method for treatment of the oral mucosa cancer. The generally accepted standard of the resection boundary that provides optimal local control is 5 mm. Adequate boundaries of indentation and choice of the reconstruction method are important issues facing specialists in head and neck tumors. Aim. To evaluate parameters of the resection edge in the surgical treatment of malignant neoplasms of the oral mucosa depending on the method of eliminating of the post-resection defect and its effect on the frequency of local relapse. Materials and methods. A retrospective analysis included 168 primary patients (50 % men and 50 % women) who received surgical treatment in the head and neck tumor department of the Republican Clinical Oncology Dispensary of the ministry of Health of the Republic of Bashkortostan (ufa) from 2019 to 2023. The median age of patients was 63 years (interquartile range (IQR) 55–69 years). most often, the primary tumor was located in the tongue – in 59.5 % (100/168) of cases. According to the method of post-resection defect removal, the patients were divided into 3 groups. In group 1, reconstruction was performed with local tissues (n = 71), in group 2 – with pedicle flaps (n = 41), and in group 3 – with revascularized flaps (n = 56). The median follow-up period was 18 months (IQR 8–28 months). Results. Resection boundaries in group 1 were 7.0 mm (IQR 5.0–12.5 mm), in group 2 – 6.5 mm (IQR 5–13 mm), and in group 3 – 12.5 mm (IQR 7.5–15.0 mm). The overall frequency of near/positive resection boundaries was 14.8 % (25/168). In group 1, it was 15.5 % (11/71), in group 2 – 19.5 % (8/41), in group 3 – 10.7 % (6/56). According to the analysis, relapse of the disease after radical treatment was noted in 32 % (55/168) of patients, of which 14.8 % (25/168) had a local relapse, 12.5 % (21/168) had a regional relapse, and 5.4 % (9/168) developed distant metastases. The frequency of local relapse in group 1 was 18.3 % (13/71), in group 2 – 23.8 % (10/41), in group 3 – 5.5 % (3/56). According to the analysis data, statistically significant differences in the boundary of indentation in the groups were revealed depending on the reconstruction method (p = 0.005). Conclusion. Based on the results of the present retrospective analysis, the choice of reconstruction method affects the resection boundary in real clinical practice. Limitations in the surgical indentation that surgeon faces when choosing a method for eliminating a post-resection defect are demonstrated.
Ultrasound diagnostics: assessment of tumor thickness and depth of invasion in squamous cell carcinoma of the oral cavity
Authors: Allakhverdieva G. F. , Dronova E. L. , Danzanova T. Yu. , Bacev A. F. , Pak M. B. , Kamolova F. Sh. 
Published: April 2024

Aim. To evaluate the capabilities of ultrasound using various approaches in determining the depth of invasion of squamous cell carcinoma of the oral cavity and to compare the results obtained with data obtained by the use of other diagnostic methods. Materials and methods. In our reserch, ultrasonography was performed on 193 patients with primary malignant tumors of the mobile part of the tongue, floor of the oral cavity and tumors of rare locations (mucous membranes of the lip, cheek, alveolar processes). The age of the patients ranged from 15 to 85 years. In all patients, tumors were squamous cell carcinoma. ultrasound was performed using submandibular, intraoral and transbuccal approaches. ultrasonic data were compared with the results of pathomorphological examination, as well as of X-ray computed tomography and of magnetic resonance imaging with contrast. Results. A statistically significantly high correlation was obtained for all ultrasound approaches (submandibular, intraoral and transbuccal) with the depth of invasion of the oral tumor determined pathomorphologically (r = 0.78; r = 0.89; r = 0.93; p <0.001). Ultrasound using all approaches shows statistically significantly better results in determining the thickness of tumorsof the tongue and mouth floor in comparison with X-ray computed tomography and magnetic resonance imaging (p <0.001). All diagnostic methods are characterized by an overestimation of the tumor invasion depth (overdiagnosis) as compared with pathomorphological examination. for exophytic tumors and oral cavity tumors of mixed growth with an exophytic component, the depth of invasion was less than the tumor thickness. Conclusion. Ultrasound is an accessible, easily reproducible, radiation-free method, the resolution of which makes it possible to accurately determine not only the depth of invasion of oral tumors, but also the distance from the tumor to the midline of the tongue, that represents an important information when choosing the extent of surgical intervention.
Low expression of the <i>ST6GAL2</i> and <i>CD248</i> genes as an unfavorable prognostic marker of oral squamous cell carcinoma
Authors: Fedorova I. K. , Kolegova E. S. , Prostakishina E. A. , Dampilova T. D. , Patysheva M. R. , Yamshchikov P. S. , Denisov E. V. , Choynzonov E. L. , Kulbakin D. E. 
Published: April 2024

Introduction. Squamous cell carcinoma (SCC) of the oral cavity is an aggressive and rapidly progressing disease. The tendency to progression of the tumor process is due to the clinical and pathological characteristics of the patient and the biological characteristics of the tumor. molecular and genetic disorders related with transcriptome level play an important role in tumor progression, which can be used in predicting the outcome of the disease. Aim. To identify markers for assessing the risk of the SCC progression. Materials and methods. Based on the data of the Cancer genome Atlas database, a bioinformatic search for genes associated with the progression of SCC was performed (11 genes were selected). Then we performed a retrospective analysis of clinical data and histological material from 38 patients with SCC treated at the Scientific Research Institute of Oncology of the Tomsk National Research medical Center of the Russian Academy of Sciences from 2018 to 2021. Fixed samples of tumor tissue were examined. The level of gene expression was determined by real-time quantitative polymerase chain reaction. Results. It was shown that decrease in the ST6GAL2 matrix RNA level is associated with presence of lymphogenic metastases and decrease in the CD248 matrix RNA level is associated with the occurrence of relapses. Conclusion. Expression level of the ST6GAL2 and CD248 genes can be used as predictors of an unfavorable prognosis of SCC.
Baseline Correction of Ground Motions for Linearly Detrended Accelerograms
Authors: Tian Shengze , Alam M. Shahria 
Published: April 2024

ABSTRACT
By revisiting the accelerograms from 42 strong-motion stations in Hualien County that recorded the 2018 Mw 6.4 Hualien earthquake, we identified that the released “raw accelerograms” were linearly detrended to remove baselines. Baseline correction for these linearly detrended accelerograms is challenging, because the baseline drift patterns are more complex than typically recognized ones. To deal with this problem, here we propose a jerk correction pattern in addition to our previously proposed tilt correction pattern and cumulative correction pattern. The modified baseline correction procedure corrects all 126 accelerograms for three directions of the 42 strong-motion stations. The recovered ground displacements are consistent with geodetic measurements, demonstrating complex surface deformations in the close vicinity of the Milun fault.
Occurrence of nosocomial multi-drug resistant Klebsiella pneumoniae in India: A systemic review and meta-analysis
Authors: Lodhi Md. Mudassar Iqbal , S A Lakshminarayana , G.P Aaftab 
Published: April 2024

The continuous rising of hospital acquired Multi Drug resistant creates an alarming condition in public health worldwide. Objective of this study is to identify quantitative analysis of hospital acquired Multi-Drug resistant in India. Data were collected from Pub Med and Google scholar specific study of India to identify prevalence of Multi-drug resistant nosocomial starting from 2011 to 2023. Literature review were collected and analysed through Preferred reporting Items for Systematic Reviews and meta-analysis (PRISMA) guideline and SPSS- 25 software used for Data analysis. Meta-analysis report reveals that prevalence of multi-drug resistant among hospital acquired is 34.37 % and pooled prevalence rate of hospital acquired multi drug resistant infection found at 2 % (97.5 % CI, 2.5) with p-value is 0.01. Genotypic analysis reveals bla gene identified most among the studied samples. Prevalence of ESBL, MDR associated with nosocomial infections estimated and correlated with mortality and death ratio as well as antibiotic susceptibility tests pattern was analysed in India which shows continuous rising number of MDR and ESBL especially hospital acquired infection. A finding of this study is indicating alarming situation of public health and it should control through interdisciplinary one health approach.
HBA2 levels in iron deficiency - Can iron deficiency mask thalassemia screening?
Authors: Tripathi Preeti , Goel Shobhit , Kumar Rajiv , Sen Arijit 
Published: April 2024

Iron deficiency has been found to affect hemoglobin A2 (HbA2) values in HPLC. This can be an issue for thalassemia screening laboratories where there is heavy reliance on increased Hb A2 levels for diagnosis of heterozygous thalassemia state. In resource constrained countries like India this could be real challenging where iron deficiency is widespread and facilities for molecular confirmation in borderline HbA2 values is generally unavailable. It was a prospective study done in a tertiary care center over 18 months. All consecutive patients (n = 164) presenting with microcytic hypochromic anemia on peripheral smear were included for further investigations out of which 92 were found to have pure iron deficiency (Hb &#60; 12 Gm/dL with ferritin less than12 ng/ml) on iron parameters. These patients were divided into two groups, Group A with Hb &#60; 9 g/dl and Group B with Hb &#62; 9 g/dl. Common hematological parameters, iron indices and HbA2 levels were analysed in these two group of patients at baseline and after 3 months of documented oral iron therapy. Chi-square and Pearson tests were used for statistical analysis and a P- value of &#60; 0.05 was considered statistically significant. As expected iron deficiency was found more prevalent in females (72%) than in males(28%). Mean pre -treatment and post - treatment hemoglobin of patients in group A was 8±0.5 gm/dl and 11.3±1.1gm/dl respectively and in group B was 10.2±0.6 g/dl and 11.5±1 g/dl showing positive correlation. Mean pre treatment and post treatment HbA2 levels of patients in group A were 1.8±0.5% and 2.4±0.5% respectively showing statistically significant change after iron therapy (P&#60; 0.0001) but mean pre treatment and post treatment HbA2 levels of patients in group B were 2.1±0.4% and 2.2±0.5% respectively . this change post therapy was statistically insignificant(P=0.1517). The change in HbA2 levels was statistically insignificant for patients with mild / moderate iron deficiency anemia (Hb &#62; 9 Gm/DL). Thus diagnosis of β thalassemia trait will not be difficult in patients with concomitant mild iron deficiency anemia but patients with severe iron deficiency anemia should first be treated with iron supplements for correct diagnosis of β Thalassemia trait especially patients with borderline Hb A2 levels.
Histopathological spectrum of upper gastro intestinal lesions in endoscopic biopsies at a tertiary care centre
Authors: Begum Sadia , Hussain Mohammed Shazeb , Padamaja K  , Anusha P  
Published: April 2024

: Gastrointestinal tract (GIT) endoscopy along with biopsy is an established procedure for investigating a wide range of gastrointestinal conditions, especially malignant and inflammatory lesions. Most common conditions requiring endoscopic biopsy of Upper GIT include dyspepsia, gastro oesophageal reflex disorder, Barrett’s esophagus, oesophageal and gastric carcinomas. : To determine the spectrum of histopathological lesions of GIT and to compare it with endoscopic findings.: The present study is an observational study done at the department of pathology of a tertiary care centre which included endoscopic biopsies of upper GIT. Biopsy specimens received were fixed in 10% formalin and processed routinely and stained with Haematoxylin and Eosin. Special stains were done as and when required. Endoscopic biopsies were analysed and assessed.: 1 It included endoscopic biopsies of esophagus, stomach, and duodenal lesions. 2. Age more than 20 years.: Inadequate and poorly fixed biopsies.A total of 177 endoscopic biopsies were studied, majority of lesions occurred in 61-70 years of age group and predominantly in males with M:F ratio 1.3:1. Out of total 177 biopsies, 21 (12%) were from esophagus, 90(51%) from stomach and 66(37%) from duodenum. The most common histopathological diagnosis in esophagus was esophagitis (47%) followed by barrettes esophagus (28%). In stomach, the most common diagnosis was gastritis (45%) followed by gastric polyps (34%) and in duodenum, it was duodenitis (66%) followed by celiac disease (18%). In comparison with endoscopic findings,100% concordance was seen with esophagitis, gastritis, duodenitis and 60% with squamous cell carcinoma in esophagus, 91% concordance with adenocarcinoma in stomach.
Mast cell leukemia- A rare case reported
Authors: Patel Disha Bipinbhai , Gandhi Shilpa H , Dhruva Gauravi 
Published: April 2024

Mast cell leukemia is a rare and aggressive clonal disorder of mast cells & their precursor cells. Systemic mastocytosis clinical course ranging from cutaneous mastocytosis, indolent disease, mast leukaemia and multisystem involvement. 14 Y/M presented with skin coloured plaque present over whole body with itching. On histopathological evaluation of skin lesion cutaneous mastocytosis was diagnosed. Further evaluation for systemic involvement by bone marrow aspiration was carried out, which shows hypercellular marrow for age, erythropoiesis and megakaryopoiesis within normal limits. The differential count revealed 70% of all nucleated cells were mast cells, with many large aggregates of &#62;15% cells and 20% atypical mast cells seen as suggestive of MAST CELL LEUKEMIA (Aleukemic leukemia). S.trptase level &#62;200ng/ml.: The presence of the major criteria-bone marrow at least 20% atypical immature mast cell with least ≥15 multifocal dense Mast cells in bone marrow or extracutaneous organ, in addition to at least one minor criterion: 1) presence of atypical morphology in more than 25% Bone marrow or extracellular mast cells 2) Serum tryptase&#62;20ng/ml. 3) Bone marrow, blood or extracutaneous organs: (a) CD2 and/or CD25 positive (b) Detection of KIT mutation at codon 816.: Considering characteristic bone marrow feature, and with biochemical and radiological investigation mast cell leukemia was diagnosed which helping clinicians to plan further management.
Awareness of hearing loss in newborns and newborn hearing screening facilities among parturient
Authors: Ravindran Greeshma , Zahir Sarah , Abraham Aju , Sasidharan Pooja Pushpa 
Published: April 2024

Parental awareness about hearing loss in newborns and newborn hearing screening programs are important for the early identification and intervention in children with hearing loss. Limited studies have explored the awareness of parturient mothers towards newborn hearing loss, newborn hearing screening, its importance and, the facilities for early hearing screening programs available at hospitals and clinics in the Indian scenario.The current study investigated the awareness of parturient about newborn hearing loss, newborn hearing screening facilities and its importance through a self- administered questionnaire survey. A total of 317 parturient across different clinics and hospitals in the city of Mangalore, state of Karnataka participated in the survey.: Majority of the parturient mothers (71.29%) were aware of the probability of hearing loss among newborns and only 56.46% of the participants had knowledge about the risk factors for newborn hearing loss. Only 42.58% have heard about newborn hearing screening before and 57.42% of the participants were unaware of the hearing screening programs available in hospitals and clinics and its importance. Despite of the education or socio-economic status, there exists a lack of knowledge among parturient mothers about hearing loss in newborns and newborn hearing screening. Responses from the current study raise concern about the need to educate the public particularly the new mothers or expecting mothers about the newborn hearing loss, risk factors for newborn hearing loss, hearing screening programs available in hospitals and clinics and its importance. Early identification of hearing loss in children is crucial for the successful implementation of early hearing intervention and better prognosis.
Inspirująca pomoc czy „zło konieczne”, czyli student pedagogiki na praktykach studenckich
Authors: Zychowicz Iwona 
Published: April 2024

Artykuł jest kontynuacją zainteresowań autorki kondycją szkół wyższych w Polsce, ich socjalizującej roli oraz jakością oferty edukacyjnej w kontekście kształtowania kompetencji pożądanych i oczekiwanych społecznie. Artykuł referuje wycinek badań nad kształtowaniem się kompetencji przyszłych pedagogów podczas praktyk studenckich. Pokazano tu opinie studentów i opiekunów praktyk.
Radiogenomic approach to glial tumors imaging under conditions of initial diagnostic measures: adaptation principles development
Authors: Maslov N. E. , Trufanov G. E. , Moiseenko V. M. , Valenkova D. A. , Efimtsev A. Yu. , Plakhotina N. A. , Sidorina A. S. 
Published: April 2024

Introduction. Radiomics is a rapidly developing field in oncology visualization aimed at searching for prognostically effective imaging features associated with specific genetic events that determine various characteristics of the disease course. According to numerous studies, the presence of IDH mutations in glial tumors determines a longer overall survival. Despite the fact that biopsy is considered to be the «gold standard» for brain tumors differential diagnosis, it is though quite difficult to perform due to the complexity of surgical access, common cases of the repeat procedure impossibility, serious complications and mortality.Aim: a search for imaging features providing prognostic data on the presence of certain mutations and gene expression in gliomas, obtained using traditional pulse sequences and characterized by the absence of restrictions on applicability depending on the tumors visible morphological features.Material and methods: retrospective analysis of 49 eligible patients' primary brain MRI data between 2021 and 2023 from Almazov National Medical Research Centre (n = 31) and Napalkov Oncological Centre (n = 18) with glial tumors and subsequently identified status of the target variable; preprocessing of MR images using the histogram matching; regions of interest determination and semi-automated slice-by-slice segmentation with subsequent extraction of radiomics features; search for predictive radiomics features regarding the status of target variable using statistical analysis tools.Results. Dependence Entropy was found to be highly effective as a predictor of IDH mutations (area under the ROC-curve – 0.766 [0.627–0.880]).Conclusions. We determined a target variable for the development of a predictive model (IDH status), a pulse sequence (T2-Tirm), a tool for initial imaging data preprocessing (histogram matching), regions of interest (tumor-associated T2-Tirm-hyperintensity including cystic and/or necrotic lesions). As a result, a statistically significant relationship between the Dependence Entropy feature and IDH status of glial tumors was found. In the course of further work it is planned to increase the size of a database, improve the accuracy of the existing statistical model, search for relevant radiomic features extracted using other traditional pulse sequences, create a comprehensive predictive radiogenomics model and develop a software.
Behavior of Gold Nanoparticles at the Interphase Boundary of Quartz–Selenide Copper and Iron at a Temperature of 450 °C and Different Selenium Activity
Authors: Akimov V.V. , Babkin D.N. , Belozerova O.Yu. 
Published: April 2024

Abstract
—In this work, based on structural and phase analysis data, we consider the behavior of Au nanoparticles (NP) during the formation of interphase boundaries between quartz and copper and iron selenides upon annealing at 450 °C and different selenium activities: lgfSe2=−2.4 with a melted selenium buffer and lgfSe2=−3.15 according to the indications of the indicator mineral mixture γ–Fe1–xSe and δ–Fe1–xSe. In two series of experiments, contrasting textural features (nano- and microstates) of the initial metal phases were used, which made it possible to construct 2D and 3D models of interphase boundaries. In the first case, thin layers of gold NPs (~30 nm thick), iron (~50 nm thick), and copper (~50 nm thick) were deposited onto quartz crystals less than 40 μm in size by magnetron sputtering, i.e., all metals were in a nanosized state. In the second case, iron, copper, and selenium (in eskebornite stoichiometry – CuFeSe2) were introduced into the system in the form of micron-sized powder materials (1–10 microns). Gold still remained in the form of NPs on the quartz surface. The thermal annealing products were studied by X-ray diffraction (XRD) and scanning electron microscopy (SEM) analyses, and X-ray photoelectron spectroscopy (XPS). The study showed that, regardless of the activity of selenium, annealing of Au NPs leads to partial enlargement of particles (up to submicron sizes) based on the self-assembly mechanism (the size distribution of Au particles corresponds to a lognormal law with a maximum shifted towards smaller sizes), and gold remains in the metallic state. The 2D model of the interphase boundary is a mineral mixture of copper selenides (Cu2Se), iron (γ–Fe1–xSe) and islands of submicron gold particles formed on the surface of quartz. The 3D model of the interphase boundary is characterized by the fact that Au particles are concentrated mainly in eskebornite, and not on the quartz surface. Moreover, NPs are localized in the pores of mesoporous eskebornite, and submicron particles with a size of ~ 200 nm or more are displaced to the surface of eskebornite particles. Based on the data obtained, typomorphic features of the presence of Au NPs in the ore-forming processes of the formation and development of gold ore deposits are formulated.