bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers and facilitators to implementing workplace interventions to promote mental health: qualitative evidence synthesis
Authors: Paterson Charlotte , Leduc Caleb , Maxwell Margaret , Aust Birgit , Strachan Heather , O'Connor Ainslie , Tsantila Fotini , Cresswell-Smith Johanna , Purebl Gyorgy , Winter Lars , Fanaj Naim , Doukani Asmae , Hogg Bridget , Corcoran Paul , D'Alessandro Luigia , Mathieu Sharna , Hegerl Ulrich , Arensman Ella , Greiner Birgit 
Published: March 2024

Abstract

Background:
Despite growing interest in workplace mental health interventions, evidence of their effectiveness is mixed. Implementation science offers a valuable lens to investigate the factors influencing successful implementation. However, evidence synthesis is lacking, especially for small-to-medium sized enterprises (SMEs) and for specific work sectors. The objectives of this review are to establish the scope of research with explicit analysis of implementation aspects of workplace mental health interventions and to identify barriers and facilitators to implementation in general and within SMEs and selected sectors.
Methods:
A systematic scoping review and meta-synthesis of mixed methods process evaluation research from 11 databases, with evaluation of methodological quality (MMAT) and confidence in findings (CERQual), was conducted. We selected information-rich studies and synthesised using domains within the Nielsen and Randall implementation framework: context, intervention activities, implementation; and mental models.
Results:
We included 43 studies published between 2009 and 2022, of which 22 were rated as information-rich to be analysed for barriers and facilitators. Most studies were conducted in healthcare. Facilitators reflecting ‘high confidence’ included: relevant and tailored content, continuous and pro-active leadership buy-in and support, internal or external change agents/champions, assistance from managers and peers, resources, and senior level experience and awareness with mental health issues. Healthcare sector specific facilitators included: easy accessibility with time provided, fostering relationships, clear communication, and perceptions of intervention. Stigma and confidentiality issues were reported as barriers overall. Due to the small number of studies within SMEs reported findings did not reach ‘high confidence’. A lack of studies in construction and Information and Communication Technology meant separate analyses were not possible.
Conclusions:
There is dependable evidence of key factors for implementation of workplace mental health interventions which should be used to improve implementation. However, there is a lack of studies in SMEs and in a larger variety of sectors.
Registration: Research Registry (reviewregistry897)
CTDSPL2 promotes the progression of non-small lung cancer through PI3K/AKT signaling via JAK1
Authors: Rong Ziye , Li Muzi , Chen La , Yu Fangfang , Mei Huijuan , Ma Xingxing , Ding Keshuo , Yang Yanan 
Published: March 2024

Abstract

Carboxy-terminal domain small phosphatase like 2 (CTDSPL2), one of the haloacid dehalogenase phosphatases, is associated with several diseases including cancer. However, the role of CTDSPL2 and its regulatory mechanism in lung cancer remain unclear. Here, we aimed to explore the clinical implications, biological functions, and molecular mechanisms of CTDSPL2 in non-small cell lung cancer (NSCLC). CTDSPL2 was identified as a novel target of the tumor suppressor miR-193a-3p. CTDSPL2 expression was significantly elevated in NSCLC tissues. Database analysis showed that CTDSPL2 expression was negatively correlated with patient survival. Depletion of CTDSPL2 inhibited the proliferation, migration, and invasion of NSCLC cells, as well as tumor growth and metastasis in mouse models. Additionally, silencing of CTDSPL2 enhanced CD4+ T cell infiltration into tumors. Moreover, CTDSPL2 interacted with JAK1 and positively regulated JAK1 expression. Subsequent experiments indicated that CTDSPL2 activated the PI3K/AKT signaling pathway through the upregulation of JAK1, thereby promoting the progression of NSCLC. In conclusion, CTDSPL2 may play an oncogenic role in NSCLC progression by activating PI3K/AKT signaling via JAK1. These findings may provide a potential target for the diagnosis and treatment of NSCLC.
Personalized Mechanical Ventilation Guided by UltraSound in Patients with Acute Respiratory Distress Syndrome (PEGASUS): study protocol for an international randomized clinical trial.
Authors: Sinnige Jante , Smit Marry , Ghose Aniruddha , de Grooth Harm-Jan , Itenov Theis Skovsgaard , Ischaki Eleni , Laffey John , Paulus Frederique , Póvoa Pedro , Pierrakos Charalampos , Pisani Luigi , Roca Oriol , Schultz Marcus , Szuldrzynski Konstanty , Tuinman Pieter Roel , Zimatore Claudio , Bos Lieuwe 
Published: March 2024

Abstract

Background: Acute respiratory distress syndrome (ARDS) is a frequent cause of hypoxemic respiratory failure with a mortality rate of approximately 30%. Identifying ARDS subphenotypes based on “focal” or “non-focal” lung morphology has the potential to better target mechanical ventilation strategies of individual patients. However, classifying morphology through chest radiography or computed tomography is either inaccurate or impractical. Lung ultrasound (LUS) is a non-invasive bedside tool that can accurately distinguish “focal” from “non-focal” lung morphology. We hypothesize that LUS-guided personalized mechanical ventilation in ARDS patients leads to a reduction in 90-day mortality compared to conventional mechanical ventilation.
Methods: The Personalized Mechanical Ventilation Guided by UltraSound in Patients with Acute Respiratory Distress Syndrome (PEGASUS) study is an investigator-initiated, international, randomized clinical trial (RCT), that plans to enroll 538 invasively ventilated adult intensive care unit (ICU) patients with moderate to severe ARDS. Eligible patients will receive a LUS exam to classify lung morphology as “focal” or “non-focal”. Thereafter, patients will be randomized within 12h after ARDS diagnosis to receive standard care or personalized ventilation where the ventilation strategy is adjusted to the morphology subphenotype, i.e., higher positive end-expiratory pressure (PEEP) and recruitment maneuvers for “non-focal” ARDS and lower PEEP and prone positioning for “focal” ARDS. The primary endpoint is all-cause mortality at day 90. Secondary outcomes are mortality at day 28, ventilator-free days at day 28, ICU length of stay, ICU mortality, hospital length of stay, hospital mortality, and number of complications (ventilator-associated pneumonia, pneumothorax, and need for rescue therapy). After a pilot phase of 80 patients, the correct interpretation of LUS images, and correct application of the intervention within the safe limits of mechanical ventilation will be evaluated.
Discussion: PEGASUS is the first RCT that compares LUS-guided personalized mechanical ventilation with conventional ventilation in invasively ventilated patients with moderate and severe ARDS. If this study demonstrates that personalized ventilation guided by LUS can improve the outcomes of ARDS patients, it has the potential to shift the existing one-size-fits-all ventilation strategy towards a more individualized approach.
Trial registration: The PEGASUS trial was registered before the inclusion of the first patient, https://clinicaltrials.gov/ (ID: NCT05492344).
Bibliometric analysis of the strategic mineral resources recycling from 1995 to 2022
Authors: Wang Zheng , wang minxi , Yang Dan , Zhao Yifei , Li Xin 
Published: March 2024

Abstract

Strategic mineral resources are the indispensable material basis for the national economy. However, with the improvement of industrialization, the demand for strategic mineral resources increases dramatically. The limited resources have caused countries to attach a new level of importance to the recycling of strategic mineral resources. Meanwhile, there has been an unprecedented increase in research on the recycling of key mineral resources in recent years. In this study, bibliometric and visualization analyses of publication data in strategic mineral resources recycling from 1995 to 2022 were conducted to reveal the development and evolution of this field and the current research hot issues. The results of the study show that the number of published literature on strategic mineral resource recycling has fluctuated year by year since 2013 and significantly increased after 2021. In terms of national publications, China, Japan, the United States (U.S.), and the European Union (EU) have conducted more research on crucial resource recycling. Especially since the 2020 United Nations General Assembly, when China's goal of "carbon peaking and carbon neutrality" was put forward, China's publications concerning critical metal recycling in the three years thereafter were twice as many as those in the previous 25 years. Regarding authorship and citations, Xu Zhenming’s team from China has a greater impact in this particular field. In addition, keyword analysis reveals that “recycling potential,” “adsorption,” and “Li” are the research frontiers and hotspots of strategic mineral resource recycling. “Recovery,” “precious metal,” and “separation” frequently appear, which are the most popular research topics. This study provides a theoretical basis for scholars to know full well about the dynamics of strategic mineral resource recycling, explore its future research direction, and realize the sustainable development of Strategic mineral resources.
The Potential of AHP-TOPSIS and Fuzzy-TOPSIS Hybrid MCDM Techniques for Evaluation of Mature Landfill Leachate Treatment Technologies
Authors: Nath Aishi , Debnath Animesh 
Published: March 2024

Abstract
Leachate is a noxious liquid with a high concentration of organic and inorganic substances produced by interactions of several environmental factors in a landfill. It is quite toxic to groundwater, surface water, and the environment; thus, it must be treated thoroughly before disposal. There are a few traditional and advanced technologies that exist for the treatment of landfill leachate, which are broadly categorized as biological, physicochemical, and hybrid technologies. According to the literature, every technology has pros and cons, and no single treatment method is sufficient to provide the required efficiency. Thus, selecting the optimal methodology for landfill leachate treatment requires a multi-criteria decision-making (MCDM) approach that incorporates several criteria and alternatives. In the research, integrated AHP-TOPSIS and integrated Fuzzy-TOPSIS approaches were employed to evaluate their potential to rank the available treatment options and to determine the optimal treatment strategy for optimal treatment of leachate. In this decision-making process, ten criteria (the removal efficiency of chemical oxygen demand (COD), biochemical oxygen demand (BOD), ammonia nitrogen, and heavy metals, operation and maintenance cost, installation time, treatment time, environmental effect, simplicity of operation and maintenance, and treatment plant flexibility with dependability) were considered. The weights of the considered criteria were determined using the AHP and Fuzzy techniques. A combination of two biological techniques, a combination of physical and biological methods, and an integration of the physicochemical method with biological methods were included among the considered alternatives (treatment approaches). The alternatives were prioritised with the help of integrated decision-making processes from a total of fifteen different treatment options. The findings indicate that membrane biological reactor (MBR) (A8), advanced oxidation process (AOPs) + MBR (A10), and coagulation-flocculation (A13) and up-flow anaerobic sludge blanket reactor (UASB) + Membrane filtration (MF) (A1) (A8>A10>A13>A1) are the first four treatment approaches as determined by only AHP, integrated AHP-TOPSIS, and Fuzzy-TOPSIS methodology. The calculated results indicate that the hybrid methods are better suited than conventional treatment approaches for toxic landfill leachate treatment.
Targeting CTLA-4 in cancer cells induces senescence via DNA-PKcs-STING-AKT axis
Authors: Shin Jeon-Soo , Lee Je-Jung , Rhee Woo Joong , Kim So Young , Lee Jisun Lee , Jung Su Ful , Park In Ho 
Published: March 2024

Abstract

Immune checkpoints such as cytotoxic T-lymphocyte associated protein 4 (CTLA-4), PD-1, and PD-L1 have been targeted for cancer therapy. However, the efficacy of this treatment approach remains limited. Beyond its expression on the T-cell surface, CTLA-4 is also expressed in various cancer cells and plays roles in cell proliferation, metastasis, and apoptosis. Here, we reveal that targeting CTLA-4 in melanoma cells leads to genomic instability and DNA-PKcs-STING-AKT pathway activation (via p53 and p21), which in turn blocks cell proliferation and induced senescence. Notably, DNA-PKcs orchestrates CTLA-4-depletion-induced senescence via the STING pathway regulation. To the best of our knowledge, this is the first study to report CTLA-4 leads senescence via micronuclei induction, which triggers DNA-PKcs and eventually suppresses cancer growth. These findings provide a better understanding of the mechanisms underlying CTLA-4 targeting-cancer therapy and future treatment strategies.
Vibration mitigation of L-shaped pipes in different intensity of vibration with particle dampers
Authors: luo yuanyi , xiao Wangqiang , zhu haiyan 
Published: March 2024

Abstract

It is particularly important to control the vibration of the pipeline. Particle dampers are often used in the vibration control of industrial pipelines. In this paper, a L-shaped industrial pipeline was taken as the research object. It was found that When the particle dampers were located in an environment with reduced acceleration Γ≤3.8, the particle dampers mainly experienced collision damping, and the dissipation performance of the particle dampers was characterized by the collision damping method. When the particle dampers were located in an environment with reduced acceleration Γ>3.8, viscous damping was mainly used, and the multi-phase flow idea could be used to predict the vibration reduction effect of the particle damper.
Physico-chemical and microbiological quality assessment of commercially available bottled waters in the United Arab Emirates
Authors: Semerjian Lucy , Elghosin Rahaf , Alsuwaidi Hind , Ebrahim Badriah , Abass Khaled 
Published: March 2024

Abstract
Bottled water quality studies in the UAE are scarce, despite high consumption rates. The aim of this study is to analyze the quality of selected local (25 brands) as well as imported (27 brands) bottled waters commercially available in the UAE in terms of both physico-chemical and microbiological parameters. Outcomes help validate compliance of the tested parameters with existing regional and international standards and explore variations between laboratory findings and reported label values. All investigated samples in current study met most regional and international standards, except nine samples were below the acceptable total dissolved solids (TDS) range, and one was below the pH range. Given that TDS and pH have minimal health impacts, the bottled waters were deemed satisfactory overall. Comparisons between test results and label values showed good agreement for pH and bicarbonate alkalinity but significant variance in TDS, total hardness, and various minerals, including hardness, magnesium, and nitrates.
Neutron Instrument Concepts for a High Intensity Moderator at the European Spallation Source
Authors: Samothrakitis Stavros , Bertelsen Mads , Willendrup Peter Kjær , Knudsen Erik Bergbäck , Larsen Camilla Buhl , Rizzi Nicola , Zanini Luca , Santoro Valentina , Strobl Markus 
Published: March 2024

Abstract

In the course of the Horizon 2020 project HighNESS, a second moderator concept has been developed for the European Spallation Source which complements the currently built moderator and is optimized for high intensity with a large viewable surface area. In this work we introduce conceptual designs for neutron instruments for condensed matter research designed to make optimal use of the capabilities of this moderator. The focus is on two concepts for small-angle neutron scattering and one neutron imaging instrument, which are intended to complement corresponding instruments that are already under construction at the European Spallation Source. One small-angle neutron scattering instrument concept resembles a conventional pinhole collimator geometry and aims to profit from the proposed second moderator by enabling to illuminate larger samples and providing particularly high resolution, drawing on a 30 m collimation and corresponding detector distance. A second small-angle neutron scattering instrument concept adopts nested mirror optics that enable to efficiently exploit the large moderator size and provide high resolution by focusing on the detector. The neutron imaging instrument concept is a typical pinhole instrument that can be found at continuous sources and draws on the corresponding strengths of high flux and large homogeneous fields-of-view, while still providing moderate wavelength resolution for advanced imaging methods.
Bio-stabilization of toxic weeds (Xanthium strumarium and Lantana camara) implementing mono- and polyculture of Eisenia fetida and Eudrilus eugeniae
Authors: Das Dimbeswar , tangjang Sumpam 
Published: March 2024

Abstract

The present study investigates the synergistic impact of earthworms (Eisenia fetida, Eudrilus eugeniae) and microbes during vermicomposting of invasive weed phytomass (Xanthium strumarium and Lantana camara). Evaluating both mono- and polyculture techniques, the research highlights the potential dual benefit of weed control and organic fertilizer production through vermitechnology. The study assesses vermicompost production, and physicochemical profiles such as pH, conductivity, total organic carbon, nitrogen, phosphorus, potassium, calcium, trace elements, and heavy metals in the end product. The Ash content, humification index, and C/N ratio analysis were conducted to assess the maturity of the vermicompost. The macronutrient enhancement in the vermicompost samples was recorded 1.5–2.47-fold for total N, 1.19–1.48-fold in available P, 1.1-1.2-fold in total K, and 1.1–1.18–-fold in total Ca. The germination index reveals a significant reduction in phytotoxicity, suggesting the production of mature and suitable vermicompost for agricultural use. Further, the earthworm population and biomass has significantly increased by the end of the 60-day experimental trial.
Study on the sustained release behavior of a slow-release scale-inhibiting material
Authors: Xiao Yang , Hao RuoSong , Zhao Shicheng 
Published: March 2024

Abstract

The phenomenon of scaling has caused great damage in many industrial production sites, especially in oil and gas field production equipment, and adding scale inhibitors is currently the most effective and commonly used method. However, this method also has the disadvantage of not being able to continuously and effectively remove scale. When there is too little scale inhibitor, it cannot have the effect of scale inhibition, but excessive scale inhibitor may lead to pseudo scaling and serious pipeline corrosion, or even environmental problems. To solve this problem, in this paper, we designed to use the degradable material polylactic acid (PLA) as the carrier, and mixed PLA with the scale inhibitor ethylenediamine tetramethylene phosphonic acid (EDTMPA) to obtain the sustained-release scale inhibition material. The sustained-release performance of the composite material was investigated through static and dynamic release experiments, and at the same time, the inhibition rate of the scale inhibitor in the process of sustained release was also investigated. Scanning electron microscopy (SEM) was used to analyze the morphology of the samples before and after the release of scale inhibitor, and the crystalline phases of calcium carbonate scale samples before and after the addition of scale inhibitors were analyzed by X-ray diffraction (XRD). The results indicate that the prepared composites can continuously release the scale inhibitor for more than 70 days, and have scale inhibition capability throughout the continuous release process. The scale inhibitor released by the slow-release scale-inhibiting material can both inhibit the formation of calcium carbonate and also destroy the calcium carbonate structure formed in the presence of the scale inhibitor, leading to lattice distortion and realizing continuous scale inhibition. This study provides a new strategy to realize the slow-release of scale inhibitors, and the prepared slow-release scale-inhibiting materials have a broad application prospect in the industry.
Inactivated Vaccine Dosage and Serum IgG Levels Correlate with Persistent COVID-19 Infection in Hematologic Malignancy Patients During the Omicron Surge in China
Authors: Ye Li , Yang Ye , Zhang Xuewu , Wang Lu , Zhu Li , Li Xia , Zhou Yile , Zheng Xiaolong , Zhou Xinping , Ren Yanling , Ma Liya , Xu Gaixiang , Yang Chunmei , Wang Huafeng , Zhou De , Yang Min , Ye Xingnong , Wei Juying , Yu Wenjuan , Qian Jiejing , Lou Yinjun , Xie Wanzhuo , Huang Jian , Meng Haitao , Jin Jie , Tong Hongyan 
Published: March 2024

Abstract

In hematologic malignancies (HM) patients, COVID-19 infections carry a significant risk of mortality due to disease status, treatment, and other factors.The risk factors of the severity and persistence of COVID-19 infections remains unclear. A study observed adults with HM diagnosed with COVID-19 from November 2022 to February 2023. Patient blood samples yielded biochemical data, with COVID-19 confirmed via RNA or antigen testing. In the examined cohort, 133 individuals diagnosed with HM and concomitantly infected with COVID-19 were scrutinized. Using advanced multivariate logistic regression, high C-reactive protein levels (≥100mg/L) significantly increased the risk of severe/critical conditions in HM patients with COVID-19 (OR: 3.415, 95% CI: 1.294-9.012; p=0.013). Patients enduring Omicron infection beyond 30 days were deemed persistent, in contrast to those achieving infection control within this duration. The research indicated that taking ＜2 vaccine doses (OR: 0.202, 95% CI: 0.048-0.857; p=0.030), having low IgG levels (＜1000 mg/dl) (OR: 0.129, 95% CI: 0.027-0.607; p=0.010), and increased interleukin-6 levels (≥12pg/ml) (OR: 5.098, 95% CI: 1.118-23.243; p=0.035) were key indicators of ongoing infection. A significant difference in survival rates was observed between patients with persistent and non-persistent infections, with the latter showing better survival outcomes (P<0.001). In conclusion, increased C-reactive protein levels had a higher likelihood of severe health outcomes for HM patients with COVID-19 infection. Persistent infections tended to be more prevalent in those with lower vaccine dosages, diminished IgG levels, and escalated interleukin-6 levels.