bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calcitonin gene‐related peptide‐targeting therapies are a first‐line option for the prevention of migraine: An American Headache Society position statement update
Authors: Charles Andrew C. , Digre Kathleen B. , Goadsby Peter J. , Robbins Matthew S. , Hershey Andrew ,   The American Headache Society
Published: March 2024

AbstractObjectiveTo provide a position statement update from The American Headache Society specifically regarding therapies targeting calcitonin gene‐related peptide (CGRP) for the prevention of migraine.BackgroundAll migraine preventive therapies previously considered to be first‐line treatments were developed for other indications and adopted later for migraine. Adherence to these therapies is often poor due to issues with efficacy and tolerability. Multiple new migraine‐specific therapies have been developed based on a broad foundation of pre‐clinical and clinical evidence showing that CGRP plays a key role in the pathogenesis of migraine. These CGRP‐targeting therapies have had a transformational impact on the management of migraine but are still not widely considered to be first‐line approaches.MethodsEvidence regarding migraine preventive therapies including primary and secondary endpoints from randomized placebo‐controlled clinical trials, post hoc analyses and open‐label extensions of these trials, and prospective and retrospective observational studies were collected from a variety of sources including PubMed, Google Scholar, and ClinicalTrials.gov. The results and conclusions based upon these results were reviewed and discussed by the Board of Directors of The American Headache Society to confirm consistency with clinical experience and to achieve consensus.ResultsThe evidence for the efficacy, tolerability, and safety of CGRP‐targeting migraine preventive therapies (the monoclonal antibodies: erenumab, fremanezumab, galcanezumab, and eptinezumab, and the gepants: rimegepant and atogepant) is substantial, and vastly exceeds that for any other preventive treatment approach. The evidence remains consistent across different individual CGRP‐targeting treatments and is corroborated by extensive “real‐world” clinical experience. The data indicates that the efficacy and tolerability of CGRP‐targeting therapies are equal to or greater than those of previous first‐line therapies and that serious adverse events associated with CGRP‐targeting therapies are rare.ConclusionThe CGRP‐targeting therapies should be considered as a first‐line approach for migraine prevention along with previous first‐line treatments without a requirement for prior failure of other classes of migraine preventive treatment.
Intermittent hydrothermal alteration and silicification of black mudstones found in the Middle to Upper Miocene Yagen Formation, Shimokita Peninsula, Northeast Japan
Authors: Ueda Hirokazu , Sampei Yoshikazu 
Published: March 2024

AbstractOrganic geochemical processes in hydrothermal alteration system in terrestrial areas were investigated in the Shimofuro geothermal field, Northeast Japan. This study describes a continuous long mudstone outcrop of the Middle to Late Miocene Yagen Formation on the Shimokita Peninsula, Aomori Prefecture. The outcrop located near Mt.Hiuchi‐dake shows sequential alteration with a color change from black to white. Contents of total organic carbon (TOC) vary from 0.00% to 0.46% according to litho‐color change and become higher for black and lower for gray to white. TOC contents show a negative correlation with SiO2 concentration. These indicate that TOC contents in the outcrop strongly depend on silicification caused by hydrothermal alteration. The mineral assemblages are composed of alunite, kaolinite, illite and pyrite, and indicate distinct alteration zones with acidic to neutral hydrothermal activities. Composition of the minerals formed by the alteration suggests that the temperature of hydrothermal fluid ranged from 150 to 250°C in a high‐sulfidation hydrothermal system. Regarding the extracted hydrocarbons, particularly n‐alkane distributions are significant. Values of Carbon Preference Index (CPI) increase up to 2.8 with increasing alteration and with decreasing TOC contents. This can be explained by two processes, (1) at the site of highly hydrothermal alteration, thermal cracking of organic matter in black mudstone strongly occurred and produced low‐molecular gaseous hydrocarbons, and (2) at the site of inner rock with a distance from the hydrothermal alteration, thermal cracking moderately occurred and produced medium to long chain n‐alkanes which were overlapped with original n‐alkanes. Very low Tmax values were found at the hydrothermal zone. This implies that natural extraction, migration, and precipitation of bituminous organic matter were driven by hydrothermal fluid.
The role of monocyte/macrophage chemokines in pathogenesis of osteoarthritis: A review
Authors: Luo Hao , Li Linfeng , Han Song , Liu Tao 
Published: March 2024

AbstractOsteoarthritis (OA) is one of the most common degenerative diseases characterised by joint pain, swelling and decreased mobility, with its main pathological features being articular synovitis, cartilage degeneration and osteophyte formation. Inflammatory cytokines and chemokines secreted by activated immunocytes can trigger various inflammatory and immune responses in articular cartilage and synovium, contributing to the genesis and development of OA. A series of monocyte/macrophage chemokines, including monocyte chemotaxis protein (MCP)‐1/CCL2, MCP2/CCL8, macrophage inflammatory protein (MIP)‐1α/CCL3, MIP‐1β/CCL4, MIP‐3α/CCL20, regulated upon activation, normal T‐cell expressed and secreted /CCL5, CCL17 and macrophage‐derived chemokine/CCL22, was proven to transmit cell signals by binding to G protein–coupled receptors on recipient cell surface, mediating and promoting inflammation in OA joints. However, the underlying mechanism of these chemokines in the pathogenesis of OA remains still elusive. Here, published literature was reviewed, and the function and mechanisms of monocyte/macrophage chemokines in OA pathogenesis were summarised. The symptoms and disease progression of OA were found to be effectively alleviated when the expression of these chemokines is inhibited. Elucidating these mechanisms could contribute to further understand how OA develops and provide potential targets for the early diagnosis of arthritis and drug treatment to delay or even halt OA progression.
Evolution of genome diagnostics in epidermolysis bullosa: Unveiling the power of next‐generation sequencing
Authors: Baardman R. , Lemmink H. H. , Yenamandra V. K. , Commandeur‐Jan S. Z. , Viel M. , Kooi K. A. , Diercks G. F. H. , Meijer R. , van Geel M. , Scheffer H. , Sinke R. J. , Sikkema‐Raddatz B. , Bolling M. C. , van den Akker P. C. 
Published: March 2024

AbstractBackgroundGenome diagnostics is considered gold standard diagnostics for epidermolysis bullosa (EB), a phenotypically and genetically heterogeneous group of rare disorders characterized by blistering and wounding of mucocutaneous tissues. EB is caused by pathogenic variants in genes encoding proteins of the dermo‐epidermal junction. Accurate genetic diagnosis of EB is crucial for prognostication, counselling and precision‐medicine. Genome diagnostics for EB started in 1991 with the introduction of Sanger sequencing (SS), analysing one gene at a time. In 2013, SS was superseded by next‐generation sequencing (NGS), that allow for high‐throughput sequencing of multiple genes in parallel. Several studies have shown a beneficial role for NGS in EB diagnostics, but its true benefit has not been quantified.ObjectivesTo determine the benefit of NGS in EB by systematically evaluating the performance of different genome diagnostics used over time based on robust data from the Dutch EB Registry.MethodsThe diagnostic performances of SS and NGS were systematically evaluated in a retrospective observational study including all index cases with a clinical diagnosis of EB in whom genome diagnostics was performed between 01 January 1994 and 01 January 2022 (n = 308), registered at the Dutch EB Expertise Centre.ResultsOver time, a genetic diagnosis was made in 289/308 (94%) EB cases. The diagnostic yield increased from 89% (SS) to 95% (NGS). Most importantly, NGS significantly reduced diagnostic turnaround time (39 days vs. 211 days, p < 0.001). The likelihood of detecting variants of uncertain significance and additional findings increased from 5% and 1% (SS) to 22% and 13% (NGS) respectively.ConclusionsOur study quantifies the benefit of NGS‐based methods and demonstrate they have had a major impact on EB diagnostics through an increased diagnostic yield and a dramatically decreased turnaround time (39 days). Although our diagnostic yield is high (95%), further improvement of genome diagnostics is urgently needed to provide a genetic diagnosis in all EB patients.
Spatial wage disparities and human capital externalities in France
Authors: Charruau Paul 
Published: March 2024

AbstractWe re‐examine the respective role of local density and local concentration of human capital in the agglomeration gains for about 750,00 individuals working in 304 commuting zones of metropolitan France over the period 2009–2015. Agglomeration gains are mostly driven by human capital effects over this period. Also, because it absorbs dynamic learning effects, the use of worker fixed effects to address spatial sorting of individuals may underestimate, by about two third, the wage premium with respect to local concentration of human capital over a midterm period. Finally, wage gaps stem more from differences in human capital in the private sector than in the public sector. We do not find evidence of a multiplier effect of public employment on local human capital externalities in the private sector.
Assessment of hemostasis in hyperthyroid and euthyroid cats using two viscoelastic assays and platelet aggregometry
Authors: Moreno Daniel , Cosford Kevin , Snead Elisabeth , Carr Anthony 
Published: March 2024

AbstractBackgroundHyperthyroidism in humans is associated with a hypercoagulable state and an increased risk of thromboembolism.ObjectiveTo evaluate hemostatic variables in hyperthyroid and euthyroid cats with the hypothesis that hyperthyroid cats will have evidence of altered hemostasis consistent with a potential hypercoagulable state.AnimalsClient‐owned hyperthyroid (n = 16) and euthyroid (n = 15) cats over 8 years of age.MethodsProspective observational study. Hyperthyroid and euthyroid cats were enrolled. Rotational thromboelastometry (ROTEM), whole‐blood platelet impedance aggregometry (WBPIA) and a point‐of‐care viscoelastic coagulation monitor (VCM‐Vet) were performed immediately after minimally traumatic venipuncture under sedation.ResultsHyperthyroid cats had significantly higher values for variables as assessed by VCM‐Vet: A10 (34 [17‐47] vs 25 [17‐38], P = .003); A20 (39.5 [23‐55] vs 31 [21‐45], P = .003); and MCF (41 [24‐58] vs 35 [22‐49], P = .03). Hyperthyroid cats had significantly different values versus the euthyroid cohort as assessed by different ROTEM channels: increased A10, INTEM (61.5 [39‐75] vs 54 [23‐66], P = .007) and FIBTEM (18 [10‐35] vs 13 [2‐27], P = .01); increased A20, INTEM (68 [45‐78] vs 61 [30‐70], P = .006) and FIBTEM (17 [10‐34] vs 11 [2‐25], P = .002); increased MCF, EXTEM (72 [65‐81] vs 69 [34‐78], P = .04), INTEM (70 [45‐85] vs 62 [35‐71], P = .01) and FIBTEM (18 [13‐37] vs 14 [3‐27], P = .02); increased alpha angle, EXTEM (80 [68‐85] vs 76 [41‐84], P = .01); shortened CT, EXTEM (52.5 [29‐73] vs 60 [52‐92], P = .003) and FIBTEM (52.5 [16‐75] vs 65 [53‐165], P = .001); and decreased ML, FIBTEM (20 [1‐36] vs 33 [19‐59], P <.001). No significant differences were found with WBPIA.Conclusions and Clinical ImportanceThe hyperthyroid cats in this study had evidence of altered hemostasis as assessed by 2 viscoelastic methodologies, and characterized by increased clot amplitude, firmness, and faster coagulation times vs euthyroid controls.
Association between personality traits and psychological distress among postmenopausal women with coronary heart disease: A cross‐sectional survey and mediation analysis
Authors: Liu Xin , Jin Jianfen , Yu Mengying , Shen Lishui , Ning Li , Zheng Beibei 
Published: March 2024

AbstractPostmenopausal women with negative personality characteristics are at an increased risk of psychological disorders, yet little is known about the mechanism underlying the relationship between type D personality and psychological distress in postmenopausal women with coronary disease. This study assessed the mediating roles of perceived social support and self‐perceived burden in the relationship between type D and psychological distress based on the equity theory and stress‐buffering model. Demographic characteristics, type D, psychological distress, perceived social support, and self‐perceived burden were completed by 335 participants with self‐reported questionnaires using a cross‐sectional design in Southeast China. The results revealed that perceived social support and self‐perceived burden both separately and serially mediated the relationship between type D personality and psychological distress. Effective intervention strategies aimed at improving perceived social support or reducing self‐perceived burden may be beneficial in reducing psychological distress.
Epidemiology of functional dyspepsia and gastroparesis as diagnosed in Flemish‐Belgian primary care: A registry‐based study from the Intego database
Authors: Huang I‐Hsuan , Schol Jolien , Lin Guohao , Chen Yaozhu J. , Carbone Florencia , Vaes Bert , Tack Jan 
Published: March 2024

AbstractBackgroundDyspepsia is a prevalent condition in the general population. Besides organic causes, the differential diagnosis of dyspepsia includes functional dyspepsia (FD) and gastroparesis (GP) which share similar pathophysiological mechanisms and clinical presentation. So far, no study investigated the prevalence of FD and GP in a primary care in Belgium.MethodsData were obtained from Intego, a Flemish‐Belgian general practice‐based morbidity registration network. From 586,164 patients between 2000 and 2021, we selected patients with ICD‐10 code for FD and GP. Patients with organic gastrointestinal diseases were excluded. We determined demographics and comorbidities of FD/GP. For prevalence and incidence calculation, we included those who consulted their general practitioners at least once in the given year. Pair‐wise comparison was conducted to access the impact of comorbidities on risk of FD/GP.Key ResultsBetween 2011 and 2021, the prevalence of FD/GP ranged from 1.03% to 1.21%. The incidence of FD/GP ranged from 109 to 142 per 100,000 adults. In total 5242 cases of FD/GP were identified. These cases shared commonly coexisting diagnoses of gastroesophageal reflux disease (18.8%), irritable bowel syndrome (17.1%), and chronic constipation (18.7%). Patients with somatization/anxiety/depression had significantly higher risk of FD/GP, compared to the control (OR 1.38, 95% CI 1.19–1.61, p < 0.01).Conclusions and InferencesThe prevalence (1.03%–1.21%) and incidence (109–142/100,000) of FD/GP in primary care over last decade appear to conflict with epidemiological research in the general population. The discrepancies suggest a potential lack of awareness of FD and GP among physicians and/or patients in Flemish‐Belgium.
COVID‐19 impact on post‐traumatic stress symptoms in burning mouth syndrome: A multicentric study
Authors: Ottaviani Giulia , Canfora Federica , Leuci Stefania , Coppola Noemi , Pecoraro Giuseppe , Rupel Katia , Bogdan Preda Magdalena Theodora , Vello Veronica , Umberto Albert , Gasparro Roberta , Gobbo Margherita , Guarda‐Nardini Luca , Giudice Amerigo , Calabria Elena , Aria Massimo , D'Aniello Luca , Fortuna Giulio , Biasotto Matteo , Di Lenarda Roberto , Mignogna Michele Davide , Adamo Daniela 
Published: March 2024

AbstractObjectivesThis study investigates the psychological impact of COVID‐19 on burning mouth syndrome (BMS) patients. It focuses on comparing post‐traumatic stress symptoms (PTSS), post‐traumatic growth (PTG), and resilience between BMS patients and Controls.MethodsA total of 100 BMS patients and 100 Controls from five Italian centers participated in this observational cross‐sectional study. They completed several assessments, including the General Health Questionnaire, Depression Anxiety and Stress Scale, Insomnia Severity Index, National Stressful Events Survey Short Scale, Impact of Event Scale‐Revised, Post Traumatic Growth Inventory Short Form, and Connor‐Davidson Resilience Scale.ResultsBMS patients had significantly higher stress, anxiety, and depression (DASS‐21 score) and post‐traumatic stress symptoms (IES‐R‐6 score), particularly in terms of intrusive thoughts. They showed lower post‐traumatic growth (PTGI‐SF score) compared to Controls. The resilience scale (CDRS‐10) was a key predictor of PTG in both groups, explaining a significant variance in PTGI‐SF scores.ConclusionsBMS patients experienced heightened post‐traumatic stress, stress, anxiety, and depression during the COVID‐19 pandemic, with reduced post‐traumatic growth. This highlights the need to prioritize their psychological well‐being, focusing on stress management and fostering post‐traumatic growth in challenging times.
Manganese drives ferroptosis of cancer cells via YAP/TAZ phase separation activated ACSL4 in OSCC
Authors: Chen Hao , Cui Hao , Liu Wei , Li Bo‐Wen , Tian Zhen , Zhao Yu‐Yue , Yu Guang‐Tao 
Published: March 2024

AbstractObjectiveFerroptosis has been defined as a novel form of regulated cell death characterized by iron‐dependent lipid peroxidation. Manganese has been used to induce ferroptosis in cancer cells recently. This study aims to investigate whether manganese can induce ferroptosis in oral squamous cell carcinoma (OSCC) and the underlying biological mechanisms.Materials and MethodsCancer cells with or without manganese treatment were analyzed by RNA‐sequencing to identify ferroptosis‐related genes. Next, the activation of YAP/TAZ/ACSL4‐ferroptosis signaling pathway was detected. Bioinformatic analysis and immunofluorescence assay were used to explore the phase separation of YAP/TAZ. Finally, specimens of OSCC patients were applied to analyze the clinical significance of YAP/TAZ/ACSL4.ResultsRNA‐sequencing analysis showed the ferroptosis‐related genes and YAP/TAZ were upregulated after manganese treatment. The results of immunofluorescence, ELISA, western blotting, etc. further confirmed that manganese‐induced ferroptosis depends on YAP/TAZ/ACSL4 signaling pathway. Moreover, the activation of ACSL4 was achieved by YAP/TAZ phase separation. The survival analysis in OSCC specimen suggested that the higher level of YAP/TAZ‐ACSL4 axis expression indicates longer survival.ConclusionsManganese induces YAP/TAZ phase separation and subsequent ACSL4 activation via YAP/TAZ nuclear translocation, which facilitates ferroptosis of OSCC. Then YAP/TAZ‐ACSL4 axis can be used as a potential prognostic predictor of OSCC patients.
High level of C3 is associated with Th2 immune response and liver fibrosis in patients with schistosomiasis
Authors: Wang Xianmo , Gong Quan , Nie Hao , Tu Jiancheng , Fan Wen , Tan Xiaoping 
Published: March 2024

AbstractLong‐term infection of schistosomiasis will seriously affect the liver health of patients. The serum of 334 chronic Schistosoma japonicum patients and 149 healthy volunteers was collected. Compared with heathy people, the level of C4 (complement 4) was increased, and the level of C3 (complement 3) was in an obvious skewed distribution. ELISA was performed to detect the serum cytokines, the results showed that the levels of IFN‐γ (interferon‐γ), IL (interleukin)‐2 and TNF‐α (tumour necrosis factor‐α) were reduced, while the levels of Th2 cytokines (IL‐4, IL‐6 and IL‐10) were increased. In the serum of patients with high C3, the secretion of HA (hyaluronic acid), LN (laminin), IV‐C (type IV collagen) and PCIII (type III procollagen) were increased, the activation of hepatic stellate cells was promoted. Exogenous human recombinant C3 made mice liver structure of the mice damaged and collagen deposition. IFN‐γ and IFN‐γ/IL‐4 were decreased, while HA, LN, PCIII and IV‐C were increased, and the expressions of α‐SMA and TGF‐β1 in liver tissues were up‐regulated. However, the addition of IFN‐γ partially reversed the effect of C3 on promoting fibrosis. High level of C3 is associated with Th2 immune response and liver fibrosis in patients with schistosomiasis.
An ontology‐based rule mapping approach for integrating IFC and CityGML
Authors: Ji Yuxin , Wang Yiran , Wei Yuxiang , Wang Jihua , Yan Wei 
Published: March 2024

AbstractBuilding information modeling (BIM) and geographic information system (GIS) are often integrated to achieve more refined urban management. Industry Foundation Classes (IFC) and City Geography Markup Language (CityGML) are widely used standards in BIM and GIS. The main problem of the transformation of these two standards lies in the gap between them in geometry and semantics. This article introduces an ontology‐based rule mapping approach, achieving the transformation from IFC to CityGML through coordinate system conversion, geometric expression conversion, and semantic mapping. For semantic mapping, we have designed and established rules, enabling the effective mapping of the IFC model to the CityGML level of detail 0 (LOD0) to LOD4 model based on entities, appearance properties and building properties. To fully demonstrate the entire process, we give a detailed elaboration of the conversion of several IFC models.
Experimental Study of Lubricant Distribution and Lubrication Enhancement Induced by Ball Bearing Cage
Authors: Jin Xuyang , Li Xinming , Liu Yao , Gao Junbin , Bai Linqing 
Published: March 2024

Abstract
The bearing cage played a pivotal role in affecting the lubricant redistribution and lubrication states. In this study, a cage unit is incorporated into an optical ball-on-disc apparatus for the purpose of a quantitative study of cage-induced lubrication phenomena. It is found that the presence of the lubricant layer on the ball surface, shaped by the cage, affects the inlet lubricant supply of contact between the ball and the glass disc. Thereafter, the oil reservoirs surrounding the contact area and the film thickness were measured. The results showed that the lubricant reservoirs and inlet lubricant supplement were significantly improved with the employment of the cages. In addition, the lubrication state transformed from starved to fully flooded, effectively enhancing the lubrication state. Moreover, the lubricant on the steel ball surface moved from the side bands to the central rolling track, indicating that the lubricant redistribution was the main reason for the lubricating enhancement. Notably, the groove modification on the inner surface of the cage pocket facilitated the directional lubricant migration and the migration effect depended on the groove angles. In conclusion, these results offer an in-depth understanding of the bearing lubrication mechanism, thereby inspiring advancements in cage design and lubricant flow regulation.