bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibacterial potentials of extracts from Gryllotalpa gryllotalpa, Pentodon algerinum grubs, and Gypsonoma euphraticana larva frass
Authors: Bader Muhanad Faleh , Mekhlif Atallah Fahad 
Published: March 2024

Objectives:
The overuse and abuse of antibiotics have accelerated antibiotic resistance, and to solve this problem, it has been found that many insect species have potential antimicrobial properties against a wide range of resistant pathogens. Our study tests the antibacterial activity of microbial defensive compounds included in body extract of insects inhabiting contaminated environments and frass of phytophagous insects.

Materials and Methods:
Through sequential extraction method by acidic methanol, chloroform, and hexane solvents, insect body extract of Gryllotalpa gryllotalpa, grubs of Pentodon algerinum besides feces of Gypsonoma euphraticana larvae were tested against Gram-positives Bacillus cereus, Bacillus coagulans, Staphylococcus aureus, and Salmonella typhi, Escherichia coli, and Klebsiella pneumoniae. The antibiotics ceftriaxone (CRO) and ampicillin (AM) were used as standard drugs. The antibacterial growth inhibition was estimated by well diffusion methods.

Results:
High significant antibacterial activity against the tested bacteria by acidic methanol then chloroform extracts, while hexane extract of all the three insect species only produced significant growth inhibition of S. aureus. In addition, growth inhibition 20.0 mm or more was induced by: MeOH extracts of G. gryllotalpa and P. algerinum for S. typhi and E. coli, besides chloroform G. gryllotalpa extract for S. typhi. The tested bacteria S. aureus, S. typhi, and K. pneumoniae were AM-resistant, while E. coli was both AM and CRO-resistant.

Conclusion:
Acidic meOH and chloroform body extract of G. gryllotalpa and P. algerinum and larvae G. euphraticana feces extract possess bioactive compounds with promising antibacterial properties, for overcoming antibiotic resistance.
PENGHINDARAN PAJAK, TRANSFER PRICING, MEKANISME GOOD CORPORATE GOVERNANCE, DAN CORPORATE SOCIAL RESPONSIBILITY PADA PERUSAHAAN PERTAMBANGAN DI INDONESIA
Authors: Rahmawati Anisa Jasni , Indrawati Novita , Al Azhar L  , Sofyan Azhari 
Published: March 2024

Abstrak: Penelitian ini bertujuan untuk menganalisis pengaruh transfer pricing, good corporate governace, corporate social responsibility, dan tingkat pengembalian aset terhadap penghindaran pajak pada perusahaan pertambangan di Indonesia. Sampel dalam penelitian ini berjumlah 19 perusahaan pertambangan yang diseleksi menggunakan metode purposive sampling. Data dianalisis menggunakan regresi linear berganda. Hasil penelitian membuktikan bahwa mekanisme good corporate governance berpengaruh negatif signifikan terhadap penghindaran pajak. Corporate social responsibility berpengaruh positif signifikan terhadap penghindaran pajak. Sedangkan transfer pricing dan tingkat pengembalian aset tidak berpengaruh terhadap penghindaran pajak. Penelitian ini berkontribusi bahwa tanggungjawab sosial perusahaan perlu dipertimbangkan sebagai salah satu indikator dalam mengungkapkan praktik penghindaran pajak, sedangkan good corporate governace yang baik dapat memberikan dampak positif sehingga mencegah perusahaan untuk tidak melakukan penghindaran pajak.
Kata Kunci: corporate sosial responsibility, good corporate governace, tinggat pengembalian aset, penghindaran pajak, transfer pricing
The Impact of Brand Value on Business Performance: An Analysis of Moderating Effects of Product Involvement
Authors: Tripopsakul Suchart , Puriwat Wilert , Hoonsopon Danupol , Na Songkhla Ratirath 
Published: March 2024

The purposes of this study are to investigate the impact of brand value on business performance and to examine whether the impact of brand value on business performance differs between high and low product involvement. Based on the top 100 brands ranked by Interbrand in 2021, linear regression analysis and moderation analysis by SPSS and AMOS were used to examine our proposed hypotheses. The results showed that brand value had a significantly positive effect on business performance. The findings imply that stronger brand valuation impacts are associated with companies that do better financially. In other words, business revenue is significantly determined by a higher brand valuation. The result of the moderation effect reveals that product involvement moderates the effect of brand value on business performance in such a way that the association between brand value and business performance is stronger in low-involvement products than in high-involvement products. The findings validate the notion that a marketer's endeavors toward brand investments constitute a noteworthy origin of activity that adds value. Our study is one of the first to investigate, using empirical data on leading brands across several industries, the impact that brand value can have on business performance. It also broadens the scope of existing understanding regarding the moderating effect of product involvement in regulating a brand's effectiveness. Doi: 10.28991/HIJ-2024-05-01-06 Full Text: PDF
Prevalence, regional distribution, and determinants of infertility in Uganda between 2006 and 2016: analysis of three Demographic and Health Surveys
Authors: Zaake Daniel , Amongin Dinah , Beňová Lenka , Kiwanuka Suzanne .N. , Nalwadda Christine .K. , Nakafeero Mary , Riese Sara , Kayiira Anthony , Asefa Anteneh 
Published: March 2024

Background Low- and middle-income countries, particularly in the African region in-country distribution and determinants of infertility are understudied. In this study, we aimed to estimate the prevalence, regional distribution, and determinants of infertility in Uganda to inform programming. Methods We estimated the prevalence of primary and secondary infertility among women aged 20-49 years using data from the three rounds of the Uganda Demographic and Health Survey 2006, 2011, and 2016, and compared the differences across geographic regions. We pooled data sets for all three years and conducted logistic regression to identify factors associated with infertility. Results We included 16,537 women aged 20-49 years for analysis of primary infertility and 12,628 for secondary infertility. The overall prevalence of infertility (pooled across the three surveys was 6.4%. The prevalence of primary infertility was 1.4% (95% Confidence interval, CI=1.0-1.8), 0.7% (95% CI=0.5-1.0) and 0.8% (95% CI=0.6-1.0) in 2006, 2011 and 2016, respectively. The prevalence of secondary infertility was 7.4% (95% CI=6.5-8.4), 6.9% (95% CI=5.9-8.0) and 7.1% (95% CI=6.4-7.9) in 2006, 2011, and 2016 respectively. The prevalence of primary infertility was similar across regions. Secondary infertility was highest in the Central (7.9%, 95% CI= 6.1-10.3, in 2016) and Northern regions (7.4%, 95% CI=6.1-8.9, in 2016). In all survey years, women with higher education had lower odds of secondary infertility compared to women with no education (adjusted odds ratio, aOR=0.54, 95% CI=0.35-0.83; P < 0.001). Conclusions Our results suggest that the prevalence of primary infertility is similar across regions, whereas secondary infertility varies by region, with higher prevalence in Central and Northern regions. More research is required to understand the drivers behind the variation of secondary infertility across regions to inform policy and decision making.
Rendam Kaki Air Jahe Hangat Mengurangi Intensitas Nyeri Ankle Pada Penderita Rheumatoid Arthritis Di Wilayah Kerja Puskesmas Singkawang Tengah I
Authors: Nurbani Nurbani , Ramayanti Ramayanti , Fittarsih Niya 
Published: March 2024

Rheumatoid Arthritis adalah terjadinya kerusakan dan proliferasi pada membran sinovial, yang menyebabkan kerusakan pada tulang sendi, ankilosis, dan deformitas sehingga menyebabkan nyeri. Tindakan non-farmakol- ogis untuk penderita Rheumatoid Arthritis diantaranya adalah hidroterapi dan kompres jahe.Tujuan penelitian ini adalah untuk menganalisis pengaruh rendam kaki air jahe hangat terhadap intensitas nyeri ankle pada pen- derita Rheumatoid Arthritis di Wilayah Kerja Puskesmas Singkawang Tengah I tahun 2018. Metode penelitian yang digunakan adalah metode kuantitatif dengan desain quasy experiment. Metode pendekatan mengguna- kan rancangan Pre and Post test Control Group Design. Analisis data menggunakan uji statistik Independent T-Test. Teknik pengambilan sampel berupa consecutive sampling pada pasien nyeri ankle Rheumatoid Arthritis dengan jumlah sampel sebanyak 14 responden terdiri dari 7 responden kelompok intervensi dan 7 responden kelompok kontrol. Instrumen yang digunakan berupa standar operasional prosedur rendam kaki air jahe hangat dan lembar observasi intensitas nyeri skala numerik. Hasil penelitian menunjukkan p value sebesar 0,00 den- ganÂ nilaiÂ signifikansiÂ sebesarÂ 0,05.Â JadiÂ P<0,005Â (HaÂ diterima). AdaÂ pengaruhÂ rendamÂ kakiÂ airÂ jaheÂ hangat terhadap intensitas nyeri ankle pada penderita Rheumatoid Arthritis di Wilayah Kerja Puskesmas Singkawang Tengah I tahun 2018.Â
Comparison between a Tail Clamp and Electrical Stimulation for Sevoflurane Minimum Anesthetic Concentration Determination in Green Iguanas (Iguana iguana)
Authors: Ghussn Laura R , Justo André A , Sanches Mariana C , Cortopassi Silvia RG , Carregaro Adriano B 
Published: March 2024

AbstractThis study aimed to compare the minimum anesthetic concentration (MAC) of sevoflurane in green iguanas using electrical stimulation and tail clamping as noxious stimuli. Seven adult green iguanas (Iguana iguana) weighing 580 to 1,300 g were enrolled. Each iguana was anesthetized twice after a 1-week washout period, with MAC being determined using a tail clamp (MACt) or electrical stimulation (MACe) techniques. After sevoflurane mask induction and endotracheal intubation, the fraction of expired sevoflurane (Fe’Sevo) was maintained at 3.1% for 15 min before noxious stimulation. In a bracketing design, the subsequent Fe’Sevo values were increased or decreased by 10% after positive or negative responses, respectively. Each targeted Fe’Sevo was kept constant for 15 min before stimulation. In MACt, the noxious stimulus involved closing a Kelly hemostatic curved forceps to the first ratchet at the base of the tail. At the same site, in MACe, 2 30 × 0.8–mm hypodermic needles inserted 1 cm apart were connected to an electrical stimulator set to deliver 30 mA at 50 Hz at a 6.5-ms interval. The hemostat and the needles were repositioned 2 cm distally and on alternate tail sides at each stimulation round. Individual MAC was obtained when 2 consecutive crossover events occurred (a positive response preceding a negative response or vice versa), with the MAC of each group represented by the average of the individual MAC values. Median (interquartile range) values for the sevoflurane MAC did not differ significantly between groups (2.2 [2.2 to 2.8%] in MACe and 2.2 [1.8 to 3.5%] in MACt; P = 0.812). Time to anesthesia induction, time to MAC measurement, heart rate (HR), end-tidal carbon dioxide (ET’CO2), and cloacal temperature were not different between groups. Both the tail-clamping and the electrical stimulation techniques yielded resembling sevoflurane MAC values in green iguanas, which makes the tail clamp a reliable alternative to electrical stimulation-based MAC research in this species.
Predictors and timing of hydrocephalus treatment in patients undergoing prenatal versus postnatal surgery for myelomeningocele
Authors: Karuparti Sasidhar , Dunbar Ashley , Varagur Kaamya , Sudanagunta Kavya , Mingo Mark , Bligard Katherine H. , Odibo Anthony , Vrecenak Jesse , McEvoy Sean , Limbrick David , Peglar Marsala Lindsay , Anadkat Jagruti , Mian Ali , Strahle Jennifer M. 
Published: March 2024

OBJECTIVE
Although hydrocephalus rates have decreased with intrauterine surgery for myelomeningocele (MMC), 40%–85% of children with MMC still go on to develop hydrocephalus. Prenatal ventricle size is known to be associated with later development of hydrocephalus; however, it is not known how prediction measures or timing of hydrocephalus treatment differ between pre- and postnatal surgery for MMC. The goal of this study was to determine anatomical, clinical, and radiological characteristics that are associated with the need for and timing of hydrocephalus treatment in patients with MMC.

METHODS
The authors retrospectively identified patients from Barnes Jewish Hospital or St. Louis Children’s Hospital between 2016 and 2021 who were diagnosed with MMC prenatally and underwent either pre- or postnatal repair. Imaging, clinical, and demographic data were examined longitudinally between treatment groups and hydrocephalus outcomes.

RESULTS
Fifty-eight patients were included (27 females, 46.6%), with a mean gestational age at birth of 36.8 weeks. Twenty-three patients (39.7%) underwent prenatal surgery. For the overall cohort, the ventricle size at prenatal ultrasound (HR 1.175, 95% CI 1.071–1.290), frontal-occipital horn ratio (FOHR) at birth > 0.50 (HR 3.603, 95% CI 1.488–8.720), and mean rate of change in head circumference (HC) in the first 90 days after birth (> 0.10 cm/day: HR 12.973, 95% CI 4.262–39.486) were identified as predictors of hydrocephalus treatment. The factors associated with hydrocephalus in the prenatal cohort were FOHR at birth > 0.50 (HR 27.828, 95% CI 2.980–259.846) and the rate of change in HC (> 0.10 cm/day: HR 39.414, 95% CI 2.035–763.262). The factors associated with hydrocephalus in the postnatal cohort were prenatal ventricle size (HR 1.126, 95% CI 1.017–1.246) and the mean rate of change in HC (> 0.10 cm/day: HR 24.202, 95% CI 5.119–114.431). FOHR (r = −0.499, p = 0.008) and birth HC (−0.409, p = 0.028) were correlated with time to hydrocephalus across both cohorts. For patients who underwent treatment for hydrocephalus, those in the prenatal surgery group were significantly more likely to develop hydrocephalus after 3 months than those treated with postnatal surgery, although the overall rate of hydrocephalus was significantly higher in the postnatal surgery group (p = 0.018).

CONCLUSIONS
Clinical and imaging factors associated with hydrocephalus treatment differ between those receiving pre- versus postnatal MMC repair, and while the overall rate of hydrocephalus is lower, those undergoing prenatal repair are more likely to develop hydrocephalus after 3 months of age. This has implications for clinical follow-up timing for patients treated prenatally, who may live at a distance from the treatment site.
Head growth in patients with myelomeningocele treated with prenatal and postnatal surgery
Authors: Karuparti Sasidhar , Flanders Tracy M. , Dunbar Ashley , Varagur Kaamya , Strahle Jennifer M. 
Published: March 2024

OBJECTIVE
The need for permanent CSF diversion is lower in patients who have undergone prenatal surgery for myelomeningocele (MMC) than in those who have undergone postnatal closure. Differences in brain development and head growth between treatment groups are not known, particularly for those who do not require surgical treatment for hydrocephalus. The objective of this study was to determine differences in head growth and to generate MMC-specific head circumference (HC) growth curves for patients who underwent either prenatal or postnatal surgery.

METHODS
The authors retrospectively identified patients from St. Louis Children’s Hospital who were treated for MMC between 2016 and 2021. HC data were obtained from birth until the most recent follow-up or hydrocephalus treatment. Nonlinear least-squares regression analysis was performed to fit the data into four models: two-term power, Gompertz, West ontogenetic, and Weibull. Subsequently, the curves were assessed for their utility in predicting hydrocephalus treatment.

RESULTS
Sixty-one patients (29 females [47.5%], 25 [41%] underwent prenatal surgery, mean gestational age at birth 36.6 weeks) were included in the study. The Weibull model best fit the HC data (prenatal adjusted R2 = 0.95, postnatal adjusted R2 = 0.95), while the Gompertz model had the worst fit (prenatal adjusted R2 = 0.56, postnatal adjusted R2 = 0.39) across both cohorts. Prenatal MMC repair patients had significantly larger HC measurements than their postnatal repair counterparts. The 50th percentile of the Weibull curve was determined as a useful threshold for hydrocephalus treatment: children with HC measurements that crossed and remained above this threshold were significantly more likely to have hydrocephalus treatment regardless of time of MMC repair (prenatal relative risk [RR] 10.0 [95% CI 1.424–70.220], sensitivity 85.7% [95% CI 0.499–0.984], and specificity 82.4% [95% CI 0.600–0.948]; postnatal RR 4.750 [95% CI 1.341–16.822], sensitivity 90.5% [95% CI 0.728–0.980], and specificity 75.0% [95% CI 0.471–0.924]). The HC growth curves of the MMC patients treated prenatally were significantly larger than the WHO HC curves (p < 0.001).

CONCLUSIONS
The Weibull model was identified as the HC growth curve with the best fit for MMC patients and serves as a useful predictor of hydrocephalus treatment. For MMC patients with hydrocephalus, prenatal repair patients fit the model well but postnatal repair patients did not, potentially indicating different mechanisms of hydrocephalus development. Those treated prenatally had significantly larger HC measurements compared with both the general population and those treated postnatally. Further study is needed to understand the long-term cognitive outcomes and optimal management of clinically asymptomatic patients with large HC measurements who were treated prenatally for MMC.
Risk factors for delayed postoperative hemorrhage in patients with brain arteriovenous malformations: an analysis of the nationwide multicenter prospective registry MATCH study
Authors: Yan Debin , Yuan Kexin , Chen Yu , Zheng Kaihong , Han Heze , Li Zhipeng , Zhang Haibin , Li Ruinan , Wang Ke , Zhang Yukun , Chen Xiaolin , Zhao Yuanli 
Published: March 2024

OBJECTIVE
Reducing the incidence of delayed postoperative hemorrhage (DPH) is one of the challenges in the surgical treatment of patients with brain arteriovenous malformations (bAVMs). This study aimed to identify several risk factors for DPH after bAVM resection and evaluate the impact of these risk factors in patients with bAVMs.

METHODS
The authors retrospectively reviewed consecutive patients with bAVMs who underwent microsurgical resection between August 2011 and September 2021. Patients were divided into either the DPH group or non-DPH group based on whether they experienced a postoperative intracerebral hemorrhage into the bAVM bed within 14 days after bAVM resection. Factors associated with DPH were assessed using multivariate logistic regression analyses.

RESULTS
A total of 1284 consecutive patients with bAVMs were evaluated; DPH events occurred in 18 patients (1.4%). There were several differences in vascular architecture between the two cohorts. A giant nidus, a nidus involved in the eloquent area, a periventricular nidus, and a nidus accompanied by venous ectasia were more likely to be associated with DPH events. The multivariate analysis identified two independent factors associated with DPH: maximum diameter (OR 1.44 per 1-cm increase, 95% CI 1.13–1.83) and periventricular lesion (OR 4.10, 95% CI 1.33–12.59). The area under the receiver operating characteristic curve for the maximum lesion diameter and development of DPH was 0.71 (95% CI 0.58–0.84). The cutoff value for the maximum bAVM diameter was 4.15 cm. Furthermore, patients with a giant bAVM, of which the maximum diameter was ≥ 4.15 cm, had a higher DPH risk after surgery (HR 5.79, 95% CI 2.01–16.67; p < 0.01). The incidence rates of DPH for patients with periventricular lesions were higher than those for patients without periventricular lesions (HR 4.50, 95% CI 1.77–11.40; p < 0.01).

CONCLUSIONS
Patients with giant bAVMs or periventricular lesions are at higher risk for DPH after surgery. Strategies such as blood pressure control, preoperative embolization, intraoperative monitoring, and careful patient selection should be considered to reduce the risk of DPH in high-risk patients.
Laser interstitial thermal therapy for new and recurrent meningioma: a prospective and retrospective case series
Authors: Chiang Veronica L. , Pugazenthi Sangami , Leidig William A. , Rodriguez Analiz , Prabhu Sujit , Haskell-Mendoza Aden P. , Fecci Peter E. , Placantonakis Dimitris G. , Abram Steven R. , Lega Bradley , Kim Albert H. 
Published: March 2024

OBJECTIVE
Meningiomas are the most common primary brain tumors in adults and a subset are aggressive lesions resistant to standard therapies. Laser interstitial thermal therapy (LITT) has been successfully applied to other brain tumors, and recent work aims to explore the safety and long-term outcome experiences of LITT for both new and recurrent meningiomas. The authors’ objective was to report safety and outcomes data of the largest cohort of LITT-treated meningioma patients to date.

METHODS
Eight United States–based hospitals enrolled patients with meningioma in the Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System (LAANTERN) prospective multicenter registry and/or contributed additional retrospective enrollments for this cohort study. Demographic, procedural, safety, and outcomes data were collected and analyzed using standard statistical methods.

RESULTS
Twenty adult patients (12 prospective and 8 retrospective) with LITT-targeted meningiomas were accrued. Patients underwent LITT for new (6 patients) and recurrent (14 patients) tumors (ranging from the 1st to 12th recurrence). The 30-day complication rate was 10%. Twenty percent of patients (4/20) had exhausted all other treatment options. Median length of follow-up was 1.3 years. One-third of new (2/6) and one-half of recurrent (7/14) meningiomas had disease progression during follow-up. One-year estimated local control (LC), progression-free survival, and overall survival rates were 55.3%, 48.4%, and 86.3%, respectively. In the 12 patients who had ≥ 91% ablative coverage, 1-year estimated LC was 61.4%. The complication rate was 10% (2/20), with 1 complication being transient and resolving postoperatively.

CONCLUSIONS
This cohort study supports the safety of the procedure for this tumor type. LITT can offer a much-needed treatment option, especially for patients with multiply recurrent meningiomas who have limited remaining alternatives.