bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is an immune-oriented use of radiation therapy possible? An increasingly open question under the spotlight of immunotherapy
Authors: Zagardo Valentina , Harikar Mandara , Ferini Gianluca 
Published: March 2024

Abstract
Historically, radiation therapy has been devoted to the achievement of local control both in early and advanced disease, palliation of symptoms (i.e. pain), and the treatment of cancer complications (i.e. bone fractures, bleeding) in advanced/metastatic cancer. Recently, the discovery of the role of radiation therapy as a trigger to activate the immune system has led to an increased interest among insiders regarding the interaction between radiation therapy and host immune reactions. The immune systemic effects of radiation therapy are widely acknowledged to be both immunosuppressive and immunostimulant, albeit there exists considerable uncertainty regarding the doses/fraction that can induce them. The main aim of this brief paper is to describe the systemic anti-tumor responses following radiation therapy on the basis of selected doses/fraction.
Phthalates and uterine disorders
Authors: Yang Shuhong , Yang Shuhao , Luo Aiyue 
Published: March 2024

Abstract
Humans are ubiquitously exposed to environmental endocrine disrupting chemicals such as phthalates. Phthalates can migrate out of products and enter the human body through ingestion, inhalation, or dermal application, can have potential estrogenic/antiestrogenic and/or androgenic/antiandrogenic activity, and are involved in many diseases. As a female reproductive organ that is regulated by hormones such as estrogen, progesterone and androgen, the uterus can develop several disorders such as leiomyoma, endometriosis and abnormal bleeding. In this review, we summarize the hormone-like activities of phthalates, in vitro studies of endometrial cells exposed to phthalates, epigenetic modifications in the uterus induced by phthalate exposure, and associations between phthalate exposure and uterine disorders such as leiomyoma and endometriosis. Moreover, we also discuss the current research gaps in understanding the relationship between phthalate exposure and uterine disorders.
The role of long noncoding RNAs in amyotrophic lateral sclerosis
Authors: Rajabi Darya , Khanmohammadi Shaghayegh , Rezaei Nima 
Published: March 2024

Abstract
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with a poor prognosis leading to death. The diagnosis and treatment of ALS are inherently challenging due to its complex pathomechanism. Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides involved in different cellular processes, incisively gene expression. In recent years, more studies have been conducted on lncRNA classes and interference in different disease pathologies, showing their promising contribution to diagnosing and treating neurodegenerative diseases. In this review, we discussed the role of lncRNAs like NEAT1 and C9orf72-as in ALS pathogenesis mechanisms caused by mutations in different genes, including TAR DNA-binding protein-43 (TDP-43), fused in sarcoma (FUS), superoxide dismutase type 1 (SOD1). NEAT1 is a well-established lncRNA in ALS pathogenesis; hence, we elaborate on its involvement in forming paraspeckles, stress response, inflammatory response, and apoptosis. Furthermore, antisense lncRNAs (as-lncRNAs), a key group of transcripts from the opposite strand of genes, including ZEB1-AS1 and ATXN2-AS, are discussed as newly identified components in the pathology of ALS. Ultimately, we review the current standing of using lncRNAs as biomarkers and therapeutic agents and the future vision of further studies on lncRNA applications.
Evidence for the presence of Borrelia burgdorferi in invasive breast cancer tissues
Authors: Patel Niraj Jatin , Thippani Sahaja , Jathan Jasmine , Gaur Gauri , Sawant Janhavi Y. , Pandya Jay M. , Sapi Eva 
Published: March 2024

AbstractBorrelia burgdorferi, the causative agent of Lyme disease, has recently been demonstrated to infect and enhance the invasive properties of breast cancer cells, while also influencing the expression of inflammatory chemokines (CXCL8 and CXCL10). This study investigates the presence of B. burgdorferi in invasive breast cancer tissues using commercially available, FDA-approved breast cancer tissue microarrays consisting of 350 ductal, 32 lobular, and 22 intraductal invasive breast carcinomas, alongside 29 normal breast tissues. Employing fluorescent immunohistochemical staining and high-resolution imaging, the findings revealed that approximately 20% of invasive lobular and ductal carcinomas, followed by 14% of intraductal carcinomas, tested positive for B. burgdorferi, while all normal breast tissues tested negative. PCR analysis further confirmed the presence of B. burgdorferi DNA in breast cancer tissues. Moreover, 25% of B. burgdorferi-positive tissues exhibited expression of both chemokines, CXCL8 and CXCL10, which was not observed in B. burgdorferi-negative tissues. Analysis of available patient data, including age, indicated a correlation between older patients and B. burgdorferi-positive tissues. This study validates the presence of B. burgdorferi in invasive breast cancer tissues and highlights the involvement of key CXCL family members associated with inflammatory processes.
Trait anxiety and corresponding neuromarkers predict internet addiction: A longitudinal study
Authors: He Miao , Mao Yu , Qiu Jiang 
Published: March 2024

AbstractBackground and AimsThe high prevalence of internet addiction (IA) has become a worldwide problem that profoundly affects people's mental health and executive function. Empirical studies have suggested trait anxiety (TA) as one of the most robust predictors of addictive behaviors. The present study investigated the neural and socio-psychological mechanisms underlying the association between TA and IA.MethodsFirstly, we tested the correlation between TA and IA. Then we investigated the longitudinal influence of TA on IA using a linear mixed effect (LME) model. Secondly, connectome-based predictive modeling (CPM) was employed to explore neuromarkers of TA, and we tested whether the identified neuromarkers of TA can predict IA. Lastly, stressful life events and default mode network (DMN) were considered as mediating variables to explore the relationship between TA and IA.FindingsA significant positive correlation between TA and IA was found and the high TA group demonstrated higher IA across time. CPM results revealed that the functional connectivity of cognitive control and emotion-regulation circuits and DMN were significantly correlated with TA. Furthermore, a significant association was found between the neuromarkers of TA and IA. Notably, the CPM results were all validated in an independent sample. The results of mediation demonstrated that stressful life events and correlated functional connectivity mediated the association between TA and IA.ConclusionsFindings of the present study facilitate a deeper understanding of the neural and socio-psychological mechanisms linking TA and IA and provide new directions for developing neural and psychological interventions.
Infusion PCTS Syntax in the Implementation of the Middle School Science Curriculum
Authors: Kurniawati Nia , Susilana Rudi , Setiawan Budi 
Published: March 2024

Curriculum implementation is an important stage in supporting the success of a curriculum designed by educational institutions. This research aims to apply the PCTS syntax in one of the science learning materials in junior high schools. PCTS is a learning model that focuses on improving students' critical thinking abilities through solving contextual problems. The method used in this research is a qualitative method using a descriptive approach. Data was collected through document study. Data analysis techniques through reduction, presentation, and conclusion. The findings obtained are that the PCTS model is quite easy to apply to science learning as a form of curriculum implementation, and is very supportive of improving students' critical thinking through the PCTS syntax, especially in the last two steps of the syntax. The conclusion is that the PCTS model is believed to support the implementation of the Merdeka Science Curriculum for Middle Schools in improving the critical thinking of individual students through the infusion of PCTS model syntax in science learning at the middle school level. AbstrakImplementasi kurikulum merupakan tahapan penting dalam menunjang keberhasilan suatu kurikulum yang dirancang oleh institusi pendidikan. Tujuan penelitian ini adalah untuk mengaplikasikan syntax PCTS dalam salah satu materi pembelajaran IPA di SMP. PCTS merupakan model pembelajaran yang berfokus pada peningkatan kemampuan berfikir kritis siswa melalui penyelesaian masalah kontekstual. Metode yang digunakan dalam penelitian ini yaitu metode kualitatif menggunakan pendekatan deskriptif. Data dikumpulkan melalui study dokumen. Teknik analisis data melalui reduksi, penyajian dan penarikan kesimpulan. Temuan yang didapat yaitu model PCTS ini cukup mudah diaplikasikan kedalam pembelajaran IPA sebagai bentuk implementasi kurikulum, dan sangat mendukung terhadap peningkatan critical thinking siswa melalui syntax PCTS, khusunya pada dua langkah terakhir syntax tersebut. Kesimpulannya bahwa Model PCTS ini diyakini akan mendukung implementasi Kurikulum Merdeka IPA SMP dalam meningkatkan critical thinking siswa secara individu melalui infusi syntax model PCTS dalam pembelajaran IPA tingkat SMP.Kata kunci: Critical thinking; implementasi kurikulum; model PCTS; pembelajaran IPA
Ancient sites as ethnomathematics for strengthening Profil Pelajar Pancasila in Malang
Authors: Utami Wikan Budi , Hariyani Sri , Aulia Fikri 
Published: March 2024

This study aims to determine the effectiveness of learning mathematics using ancient sites as a source of learning and to raise students' awareness of protecting and preserving ancient sites. The research design used was the pre and post-test group design with two groups. The experimental and control groups will be given a pretest before treatment and a posttest after treatment. The population used was 148 grade IV elementary school students, and the sample used was 120 people consisting of 60 experimental class students and 60 control class students. Data analysis in this study used statistical data processing software IBM SPSS version 27. Based on the summary of the independent t-test results, the value of Sig. (2-tailed) on the post-test data is 0.001. This value is smaller than the specified significance level of 0.05. This means that the averages of the experimental and control groups at the post-test were significantly different. The results showed that the archaeological site of Singosari temple can be used as a source of learning mathematics for elementary schools and can increase students' understanding of the preservation of ancient sites as a form of strengthening the Profil Pelajar Pancasila. AbstrakPenelitian ini mengungkap keefektifan pembelajaran matematika dengan menggunakan situs purbakala sebagai sumber belajar serta meningkatkan kesadaran siswa untuk menjaga dan melestarikan situs purbakala. Desain penelitian yang digunakan adalah pre and posttest group design dengan dua kelompok. Kelompok eksperimen dan kontrol akan diberikan pretest sebelum perlakuan dan posttest setelah perlakuan design dengan dua kelompok. Kelompok eksperimen dan kontrol akan diberikan pretest sebelum perlakuan dan posttest setelah perlakuan. Populasi yang digunakan sebanyak 148 siswa sekolah dasar kelas IV dan sampel yang digunakan sebanyak 120 orang yang terdiri dari 60 siswa kelas eksperimen dan 60 siswa kelas kontrol. Analisis data pada penelitian ini menggunakan software pengolah data statistik IBM SPSS versi 27. Berdasarkan rangkuman hasil uji t independen diperoleh nilai Sig. (2-tailed) pada data posttest 0,001. Nilai ini lebih kecil dari tingkat signifikansi yang ditentukan yaitu 0,05. Artinya rata-rata kelompok eksperimen dan kontrol pada saat posttest berbeda secara signifikan. Hasil penelitian menunjukkan bahwa situs arkeologi Candi Singosari dapat dijadikan sebagai sumber pembelajaran matematika untuk sekolah dasar dan dapat meningkatkan pemahaman siswa terhadap pelestarian situs purbakala sebagai bentuk penguatan profil siswa Pancasila.Kata Kunci: Ethnomathematic; Profil Pelajar Pancasila; situs purbakala; sumber belajar
PELAKSANAAN KEBIJAKAN DAN PENILAIAN PENGGUNAAN APD (ALAT PELINDUNG DIRI) OLEH DOKTER DAN BIDAN DI RUANG BERSALIN DAN NIFAS RSU PKU MUHAMMADIYAH YOGYAKARTA UNIT I TAHUN 2014/2015
Authors: Supiana Nia , Supriyatiningsih Supriyatiningsih 
Published: March 2024

Background: Hospital is a place for taking care of the patients where there are many kinds of disease there. Disease caused by infection is one of disease that can be found in hospital. It can be the mild one or the severe one. Therefore, it can spread from one patient to the other patients. Besides that, the workers also can be infected since their job required them to having a contact with the infection agent. The General hospital of PKU Muhammadiyah Yogyakarta Unit 1 has formed the Komite Pencegahan dan Pengendalian Infeksi (KPPI) or Committee of Prevention and Restraint of Infection since 2012, this committee has made a policy related to universal precautions which giving protection to medical staff, patients, and patients’ families.
Methods: In collecting the data, this research used mixed method with concurrent triangulation strategy design and cross-sectional approach. The population of this research is doctors in delivery and postpartum room and the members of KPPI. The total of the population is 30 people. In analyzing the data, the writer used logistic regression. The resources were taken from some related books, journals, articles, and research from several media.
Results and Discussion: The result of this research showed that the degree of compliance of doctors and midwives in using PPE (Personal Protective Equipment) in postpartum room (92.9%) was higher than the using of PPE in the delivery room (76.9%). This implementation/compliance is influenced by disposition factors/attitude (ρ = 0.000 <0.05) and the structure of bureaucracy (ρ 0,000 <0.05), while the variable of communication (ρ=0,164 > 0,05) and resource (ρ=0,431 > 0,05) do not influence on the implementation of the use of PPE.
Conclusions and Recommendations: The implementation of the use of PPE in the delivery and postpartum room is still not performing well and the evaluation process was still not optimal. The hospital is expected to improve the supervision of the head room. Moreover, the implementation of SOP (Standard Operational Procedure) on the universal Guidelines for Vigilance Implementation should be conducted especially the use of PPE in delivery and postpartum room.
A criança em sofrimento psíquico na Rede de Atenção Primária à Saúde em município gaúcho: reflexões a partir de um usuário-guia
Authors: Gallina Bruna Fátima , Pulga Vanderléia Laodete , Schneider Fabiana 
Published: March 2024

O estudo teve como objetivo problematizar as práticas de cuidado desde o itinerário terapêutico de uma criança como usuária-guia. Trata-se de uma pesquisa-intervenção de caráter qualitativo transcorrida no período de abril a dezembro de 2022 em uma Estratégia Saúde da Família (ESF), onde realizou-se entrevistas abertas individuais e grupais com usuários, trabalhadores da saúde e da escola onde a criança estuda, a fim de compreender os modos de cuidado instituídos na rede de atenção municipal diante do sofrimento psíquico infantil. A análise de conteúdo se deu a partir da leitura hermenêutica das narrativas entrelaçando-as ao referencial teórico da Psicanálise. Evidenciou-se o uso do usuário-guia como potente estratégia de cuidado e de reconhecimento subjetivo e no fortalecimento da intersetorialidade. Destaca-se, no trabalho com a infância, a importância do encontro inter-humano no cuidado para a sustentação de intervenções pautadas na escuta da singularidade e subjetividade das crianças e familiares.

Palavras-chave: Infância; Saúde Mental; Colaboração Intersetorial; Psicanálise; Atenção Primária à Saúde.
The Effect of Health Education Using Uric Acid Diary Book (URICAB) on Dietary Compliance and Uric Acid Levels in Gout Arthritis Patients
Authors: Putri Maulinda Afandi  , Wahyudi Andri Setiya , Dewi Lingga Curnia 
Published: March 2024

Introduction: Gout arthritis is a non-communicable disease that continues to increase. The prevalence of gout in Indonesia is 7.30% because the adherence to an unbalanced diet. Therefore, innovation is needed to overcome the problems in gout arthritis patients. The Uric Acid Diary Book (URICAB) is a modification of the booklet media in supporting health education. URICAB contains information related to uric acid, diet lists, and diet diary tables. This study aims to analyze the effect of health education on URICAB media on dietary compliance and uric acid levels in gout arthritis patients.
Methods: This study used the Quasy Experiment method pretest-posttest control group design with a population of 147 people and sample of 72 people. The independent variable is health education media URICAB, while the dependent variable is dietary adherence and uric acid levels in gout arthritis sufferers. The research instrument used blood samples and dietary compliance questionnaires. The data analysis used the Wilcoxon Signed Ranks Test, Mann Whitney U Test, Paired Sample T Test, and Independent Sample T Test.
Results: The results of the Mann-Whitney U Test obtained a value of p = 0.046 indicate that there are increasing dietary adherence. The results of the Independent Sample T Test obtained a value of p = 0.025 indicate that health education in URICAB media affected the reducing uric acid levels.
Conclusion: URICAB media health education had significant effect to improve dietary adherence to the recommended diet and limiting high-purin diets and adherence to drinking as recommended by health workers and reduce uric acid levels.
Comparative genomics unravels a rich set of biosynthetic gene clusters with distinct evolutionary trajectories across fungal species farmed by termites
Authors: Schmidt Suzanne , Murphy Robert , Vizueta Joel , Schierbech Signe , Conlon Benjamin , Kreuzenbeck Nina , Vreeburg Sabine , de Peppel Lennart van , Aanen Duur , Kolotchèlèma Silue , Kone N'golo , Beemelmanns Christine , Weber Tilmann , Poulsen Michael 
Published: March 2024

Abstract

The use of compounds produced by hosts or symbionts for defence against antagonists has been identified in many organisms, including in fungus-farming termites (Macrotermitinae). The obligate mutualistic fungus Termitomyces plays a central role in the symbiosis through plant biomass decomposition and as the main food source for these termites. Several specialised (secondary) metabolites have been isolated from different Termitomyces species, suggesting that they may also aid in antimicrobial defence. Yet, we have a fragmented understanding of Termitomyces’ natural product repertoire. To determine the biochemical potential encoded by diverse Termitomyces species, we comparatively analysed 22 published and 17 newly generated genomes, spanning 21 of 52 described Termitomyces species and five of the 11 termite host genera. After extensive assembly and annotation optimisation, we employed fungiSMASH to detect 754 biosynthetic gene clusters (BGCs) coding for specialised metabolites. BiG-SCAPE analysis and manual curation allowed us to assign 660 of these BGCs to 61 distinct biosynthetic gene cluster families (GCFs), spanning five compound classes. Seven GCFs were shared by all 21 Termitomyces species, 21 GCFs were present in all genomes of several subsets of species, while the remaining 33 GCFs were inconsistently distributed across species. The 25 most abundant GCFs were subjected to codon-based evolutionary constraint analyses to evaluate their evolutionary histories and revealed two GCFs with consistent positive selection in the same gene across the phylogeny and seventeen genes with Termitomyces species-specific episodic positive selection. These patterns of selection indicate that millions of years of termite-fungus symbiosis have led to distinct evolutionary trajectories of biosynthetic gene clusters, ample putative chemical novelties, and uncover a vast non-random and largely unknown chemical potential of Termitomyces.
Effect of milling and baking processes on bread quality: a case in Kamise, Ethiopia
Authors: Asmellash Tihitinna , Geleta Tollosa , Kibatu Girma 
Published: March 2024

Abstract

Milling and baking are processes which determine bread quality. Proximate compositions of wheat grains and flour samples from one central milling factory and bread samples from different bakeries in Kamise, Ethiopia were determined using standard methods in the laboratory. The fat and ash contents decreased by milling wheat grains; whereas, the moisture, protein and fat contents of the wheat flours increased in bread samples after baking. Highest amounts of Mg (243.25 ± 2.5 mg/Kg) and Ca (350.40 ± 2.2 mg/Kg) were found in the bread; while lowest concentrations of Mg (81.25 ± 0.15 mg/Kg) and a higher Ca concentrations (110.75 ± 0.2mg/Kg) were observed in flour samples. Significantly highest amount iron was obtained in the grains than in the flour and bread samples; indicating loss of iron in milling and baking processes. Lead was found on bread samples than in the grain or flour samples, indicative of the presence of contamination during baking processes. The variations between samples due to milling and differences in baking processes which could be as a result of differences in water used, additives and fermentation parameters. The evaluation of milling and baking processes in affecting nutrient composition are important to control the nutritional quality of bread.