bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water‐Soluble Nile Blue Derivatives: Syntheses and Photophysical Properties
Authors: Jose Jiney , Ueno Yuichiro , Burgess Kevin 
Published: November 2008

AbstractFour water‐soluble 2‐hydroxy‐Nile Blue derivatives, 1 a, 1 b, 2 a, and 2 b, were prepared by condensation reactions performed under relatively mild conditions (90 °C, N,N‐dimethylformamide with no added acid). These fluorescent probes had more favorable fluorescence characteristics than two known water‐soluble Nile Blue derivatives. Specifically, they were superior to the known dyes with respect to their quantum yields in aqueous media and the sharpness of their fluorescence emissions. Concentration‐dependant UV absorption and fluorescence emission studies indicated that the dyes did not aggregate in aqueous solution at concentrations of less than 1–4 μM. The new water‐soluble materials 1 a, 1 b, 2 a, and 2 b emit in a desirable region of the fluorescence spectrum (λ=670–675 nm). Overall they are potentially interesting for labeling biomolecules in aqueous environments.
Synthesis and Evaluation of 1,1′‐Hydrocarbylenebis(indazol‐3‐ols) as Potential Antimalarial Drugs
Authors: Martins Alho Miriam , García‐Sánchez Rory N. , Nogal‐Ruiz Juan José , Escario José Antonio , Gómez‐Barrio Alicia , Martínez‐Fernández Antonio R. , Arán Vicente J. 
Published: November 2008

AbstractBis(indazol‐3‐ol) derivatives (5,30–38) were prepared by alkylation of 3‐alkoxyindazoles with α,ω‐dibromides, followed by removal of the O‐protecting groups. These compounds were subsequently evaluated as inhibitors of biocrystallization of ferriprotoporphyrin IX (heme) to hemozoin, aPlasmodiumdetoxification specific process. Most bis(5‐nitroindazol‐3‐ols) were good inhibitors, however, a denitro analogue (38), the intermediate bis(3‐alkoxyindazoles) (15–29) as well as bis(indazolin‐3‐ones) (39–42) were not active, showing the importance of the NO2and OH groups in the inhibition process.
Natural‐Product‐Like Spiroketals and Fused Bicyclic Acetals as Potential Therapeutic Agents for B‐Cell Chronic Lymphocytic Leukaemia
Authors: Milroy Lech‐Gustav , Zinzalla Giovanna , Loiseau François , Qian Zizheng , Prencipe Giuseppe , Pepper Chris , Fegan Chris , Ley Steven V. 
Published: November 2008

AbstractB‐cell chronic lymphocytic leukaemia (CLL) is the most common form of leukaemia in the Western world for which no curative treatments are currently available. Purine nucleotide analogues and alkylating agents feature frequently in combination regimens to treat the malignant state, but their use has not led to any significant improvement in patient survival. Consequently, there still remains a need for alternative small‐molecule chemotherapeutics. Natural products are an unparalleled source of drug leads, and an unending inspiration for the design of small‐molecule libraries for drug discovery. The screening of focused libraries of natural‐product‐like spiroketal and fused bicyclic acetal small molecules against primary CLL cells has led to the identification of a small series of novel and potent cytotoxic agents towards primary CLL cells. The validation of the activity of these molecules is delineated through a series of synthesis and screening iterations, whereas preliminary mode of action studies positively indicate their ability to induce cell death via an apoptotic pathway with no evidence of necrosis to further support their potential as novel chemotherapeutic agents.
Deciphering the Selectivity of Bombyx mori Pheromone Binding Protein for Bombykol over Bombykal: A Theoretical Approach
Authors: Charlier Landry , Antonczak Serge , Jacquin‐Joly Emmanuelle , Cabrol‐Bass Daniel , Golebiowski Jérôme 
Published: November 2008

AbstractIn this article we report calculations dedicated to estimate the selectivity of the Bombyx mori pheromone binding protein towards the two closely related pheromonal components Bombykol and Bombykal. The selectivity is quantified by the binding free‐energy difference, obtained either by the thermodynamic integration or by the MM‐GBSA approach. In the latter, the selectivity is decomposed on a per‐residue basis, which identifies the residues considered crucial for the selectivity of the protein for Bombykol over Bombykal. A discussion on the role of Bombyx mori pheromone binding protein is provided on the basis of these results.
Aerobic FeIII–FeII Reduction in the Presence of 2,4,6‐Tri(2‐pyridyl)‐1,3,5‐triazine and Benzilic Acid: Synthesis and Characterization of a Heptacoordinate FeII–Nitrato Complex
Authors: Raptopoulou Catherine P. , Sanakis Yiannis , Boudalis Athanassios K. 
Published: November 2008

AbstractThe simultaneous presence of benzilic acid [Ph2C(OH)CO2H] and tptz [2,4,6‐tri(2‐pyridyl)‐1,3,5‐triazine] in FeIII‐containing reaction mixtures leads to partial and/or quantitative metal reduction. In the presence of the oxidative NO3– ions in the reaction mixture, partial reduction of the metal leads to the isolation of a heptacoordinate FeII–nitrato complex, [FeII(tptz)(NO3)(MeOH)2](NO3) (1), along with a FeIII complex (2). In the presence of perchlorate ions in the reaction mixture, the quantitative reduction of FeIII leads to the isolation of a hexacoordinate FeII complex, [FeII(tptzH)2](ClO4)4 (3). Complexes 1 and 3 have been structurally characterized and possess a pentagonal‐bipyramidal and a distorted octahedral coordination geometry, respectively. In both complexes, tptz behaves as a tridentate ligand, adopting the terpy‐like coordination mode, and is coordinated through the triazine nitrogen atom and the two adjacent pyridine nitrogen atoms. One asymmetrically coordinated chelate, NO3–, and two MeOH molecules complete the pentagonal‐bipyramidal geometry around FeII in 1. On the basis of analytical, spectroscopic (IR, Mössbauer) and magnetic susceptibility data from polycrystalline samples of 2, an oxido‐bridged diferric structure is proposed [ΔEQ(78 K) = 1.79 mm s–1, JFe–Fe = –117 cm–1]. The Mössbauer spectra of the polycrystalline samples of 1 and 3 are consistent with high‐spin and low‐spin FeII, respectively, in anN/O coordination environment. Variable‐temperature and variable‐field magnetic measurements of 1 suggest significant zero‐field splitting of the ferrous ions (D = 5.5 cm–1).(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Synthesis and 13C NMR Spectroscopy of Model Compounds for the Microstructure Analysis of Poly(Vinyl Glycoside)s
Authors: Yuan Jialong , Frauenrath Holger 
Published: November 2008

AbstractA series of glycosylated diol and triol derivatives was synthesized in order to serve as model compounds for the analysis of the stereochemistry, regiochemistry, and defect structures of poly(vinyl glycoside)s. 13C NMR spectroscopic analysis of these compounds revealed that the attached chiral carbohydrate substituents induced a strong correlation of the chemical shifts of both the anomeric C and the α‐C atom of the aglycon with the absolute configuration of the latter. The influence of the stereoconfiguration of β‐ and γ‐C atoms as well as the regiochemistry of the aglycon on the chemical shifts of the α‐C and the anomeric C atom was also investigated. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Very Fast Suzuki–Miyaura Reaction Catalyzed by Pd(OAc)2 under Aerobic Conditions at Room Temperature in EGME/H2O
Authors: Del Zotto Alessandro , Amoroso Francesco , Baratta Walter , Rigo Pierluigi 
Published: November 2008

AbstractThe results of a ligand‐free Pd(OAc)2‐catalyzed Suzuki–Miyaura C–C coupling performed at room temperature under aerobic conditions are presented. It was found that the use of an ethylene glycol monomethyl ether/H2O mixture as the solvent resulted in very rapid reactions of aryl bromides with arylboronic acids. As a matter of fact, under optimized conditions, some substrates were converted quantitatively in less than 1 min with exceptionally high TOF values. For example, the reaction between 4‐methoxyphenylboronic acid and bromobenzene afforded 4‐methoxybiphenyl in 30 s with TOF = 180000 h–1. Furthermore, the reaction tolerates a wide range of functional groups and can be successfully applied to heteroaryl bromides such as 2‐bromopyridine and 5‐bromopyrimidine. Interestingly, also an activated aryl chloride such as 1‐chloro‐4‐nitrobenzene reacted quantitatively with phenylboronic acid at 373 K. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
The information content of an open limit‐order book
Authors: Cao Charles , Hansch Oliver , Wang Xiaoxin 
Published: November 2008

AbstractUsing data from the Australian Stock Exchange, the authors assess the information content of an open limit‐order book with a particular focus on the incremental information contained in the limit orders behind the best bid and offer. The authors find that the order book is moderately informative—its contribution to price discovery is approximately 22%. The remaining 78% is from the best bid and offer prices on the book and the last transaction price. Furthermore, the authors find that order imbalances between the demand and supply schedules along the book are significantly related to future short‐term returns, even after controlling for the autocorrelations in return, the inside spread, and the trade imbalance. ©2008 Wiley Periodicals, Inc. Jrl Fut Mark 29:16–41, 2009
Efficient static replication of European options under exponential Lévy models
Authors: Takahashi Akihiko , Yamazaki Akira 
Published: November 2008

AbstractThis study proposes a new scheme for the static replication of European options and their portfolios. First, a general approximation formula for efficient static replication as an extension of Carr P. and Chou A. (1997, 2002) and Carr P. and Wu L. (2002) is derived. Second, a concrete procedure for implementing the scheme by applying it to plain vanilla options under exponential Lévy models is presented. Finally, numerical examples in a model developed by Carr, P., Geman, H., Madan, D., and Yor M. (2002) are used to demonstrate that the replication scheme is more efficient and more effective in practice than a standard static replication method. © 2008 Wiley Periodicals, Inc. Jrl Fut Mark 29:1–15, 2009
Stepwise accumulation of distinct genomic aberrations in a patient with progressively metastasizing ependymoma
Authors: Milde Till , Pfister Stefan , Korshunov Andrey , Deubzer Hedwig E. , Oehme Ina , Ernst Aurélie , Starzinski‐Powitz Anna , Seitz Angelika , Lichter Peter , von Deimling Andreas , Witt Olaf 
Published: November 2008

AbstractNonresectable ependymomas are associated with poor prognosis despite intensive radiochemotherapy and radiation. The molecular pathogenesis of ependymoma initiation and progression is largely unknown. We here present a case of therapy‐refractory, progressive ependymoma with cerebrospinal as well as extraneural metastases, which allowed us for the first time to follow the stepwise accumulation of chromosome aberrations during disease progression. Genome‐wide DNA copy‐number analysis showed sequential deletions on chromosomes 1, 9, and 14 as well as a homozygous deletion of the CDKN2A locus, underscoring its role in tumor progression. Gradual loss at 1p36 was associated with loss of protein expression of the putative tumor suppressor gene AJAP1/SHREW1. In summary, this is the first report on acquired genomic aberrations in ependymoma over time pointing to novel candidate tumor suppressor genes. This analysis provides molecular insights into the chronology of genetic events in this case from initial localized tumor to widespread metastasized disease. © 2008 Wiley‐Liss, Inc.
Controversies in the management of retromolar trigone carcinoma
Authors: Ayad Tareck , Guertin Louis , Soulières Denis , Belair Manon , Temam Stéphane , Nguyen‐Tân Phuc Felix 
Published: November 2008

AbstractOur objective is to discuss the current controversies that surround the management of retromolar trigone (RMT) cancer. We conducted this literature review to discuss trigone cancer. RTM and anterior pillar cancers should be studied separately. Preoperative clinical and radiographic assessments need to be further investigated to establish their reliability at predicting bone invasion. In the absence of suspicion of bone invasion, surgery and radiotherapy seem to give similar results, but recent reports indicate a greater benefit if they are used in combination. Some authors have advocated systematic segmental resection for all RMT cancers but marginal mandibulectomy is a reasonable option in selected cases. Standard treatment for RMT cancers with N0 necks is selective neck dissection or radiation therapy, depending on the modality of treatment of the primary. Allowing a better understanding of the evolution of RMT cancer and its response to different treatment modalities requires efforts to report different institutional experience with this rare tumor. © 2008 Wiley Periodicals, Inc. Head Neck, 2009
Immobilization of polyphenol oxidase on alginate–SiO2 hybrid gel: stability and preliminary applications in the removal of aqueous phenol
Authors: Shao Jian , Huang Ling‐Ling , Yang Yu‐Min 
Published: November 2008

AbstractAn organic/inorganic hybrid gel of alginate–SiO2 (ALG–SiO2) was used to immobilize the partially purified potato polyphenol oxidase (PPO) for the treatment of phenolic wastewater. The influences of alginate concentration, quantity of both enzyme and tetramethoxysilane (TMOS) on immobilization were investigated. The Michaelis constant for immobilized PPO was determined as 14.7 mmol L−1 at 25 °C, and the highest activity of immobilized PPO was achieved at pH 7.0. The ALG–SiO2 immobilized PPO was more stable than the free PPO or ALG(alone) immobilized PPO. This study suggests that ALG–SiO2 immobilized PPO might be a potential tool for the removal of phenolic compounds from industrial wastewater. Copyright © 2008 Society of Chemical Industry
Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: Ibuprofen restores its motor activity
Authors: Cauli Omar , Rodrigo Regina , Piedrafita Blanca , Llansola Marta , Mansouri Mohammad T. , Felipo Vicente 
Published: November 2008

AbstractPatients with hepatic encephalopathy show altered motor function, psychomotor slowing, and hypokinesia, which are reproduced in rats with portacaval shunts (PCS). Increased extracellular glutamate in substantia nigra pars reticulata (SNr) is responsible for hypokinesia in PCS rats. The mechanisms by which liver failure leads to increased extracellular glutamate in SNr remain unclear. Inflammation seems to act synergistically with hyperammonemia to induce neurological alterations in hepatic encephalopathy. It is therefore possible that inflammation‐associated alterations may contribute to motor alterations in hepatic encephalopathy. The aim of this work was to assess whether treatment with an antiinflammatory, ibuprofen, is able to normalize extracellular glutamate in SNr and/or to improve hypokinesia in PCS rats. The amounts of the glutamate transporters GLT‐1 and EAAC‐1 are reduced by 26% and 32%, respectively, in SNr of PCS rats. This reduction is associated with a tenfold increase in extracellular glutamate in SNr and a reduction in motor activity. Chronic treatment with 30 mg/kg ibuprofen completely normalizes the amount of GLT‐1 and EAAC‐1 and significantly reduces (by 53%) extracellular glutamate in SNr of PCS rats. Moreover, ibuprofen, at 15 or 30 (but not at 5) mg/kg/day, completely eliminates hypokinesia, restoring normal motor activity. This supports the idea that inflammation is a main contributor to the induction of hypokinesia in hepatic encephalopathy. Moreover, these data point to the possible therapeutic utility of decreasing inflammation, by safe procedures, in the treatment of the motor deficits in patients with hepatic encephalopathy. © 2008 Wiley‐Liss, Inc.
Marked loss of sympathetic nerve fibers in chronic Charcot foot of diabetic origin compared to ankle joint osteoarthritis
Authors: Koeck Franz‐Xaver , Bobrik Verena , Fassold Alexander , Grifka Joachim , Kessler Sigurd , Straub Rainer H. 
Published: November 2008

AbstractThe pathogenesis of Charcot foot is based on three disputed factors: (1) loss of neurotrophic influence, (2) microtraumatic lesions, and (3) neurovascular disturbances. These etiological causes were uncovered by clinicophysiological tests. However, no results of quantitative nerve density studies of sympathetic and sensory substance P‐positive (SP+) nerve fibers are available. We studied the density of sympathetic and SP+ nerve fibers in three distinct areas of the tarsus. Fifteen patients with ankle osteoarthritis (OA) and 15 patients with diabetic Charcot foot were included. Patients with OA did not differ from those with Charcot foot in SP+ sensory nerve fiber density. However, at all three areas, the density of sympathetic nerve fibers was significantly lower in patients with Charcot foot compared to OA (p = 0.006). In addition, we found that the sympathetic nerve repellent factor semaphorin 3C was highly expressed in inflamed tissue in Charcot patients. In Charcot foot of diabetic origin a severe loss of sympathetic nerve fibers was observed. These findings in chronically inflamed Charcot foot lend support to the neurovascular theory in the late chronic phase, which probably depends on the inflammatory upregulation of nerve repellent factors. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27: 736–741, 2009
Strontium–calcium coadministration stimulates bone matrix osteogenic factor expression and new bone formation in a large animal model
Authors: Li Zhaoyang , Lu William W. , Chiu Peter K.Y. , Lam Raymond W.M. , Xu Bing , Cheung Kenneth M.C. , Leong John C.Y. , Luk Keith D.K. 
Published: November 2008

AbstractStrontium (Sr) has become increasingly attractive for use in the prevention and treatment of osteoporosis by concomitantly inhibiting bone resorption and enhancing bone formation. Strontium shares similar chemical, physical, and biological characteristics with calcium (Ca), which has been widely used as a dietary supplement in osteoporosis. However, the effects of Sr–Ca coadministration on bone growth and remodeling are yet to be extensively reported. In this study, 18 ovariectomized goats were divided into four groups: three groups of five goats each treated with 100 mg/kg/day Ca, Ca plus 24 mg/kg/day Sr (Ca + 24Sr), or Ca plus 40 mg/kg/day Sr (Ca + 40Sr), and three untreated goats fed low calcium feed. Serum Sr levels increased 6‐ and 10‐fold in the Ca + 24Sr and Ca + 40Sr groups, respectively. Similarly, Sr in the bone increased four‐ and sixfold in these two groups. Sr–Ca coadministration considerably increased bone mineral apposition rate (MAR). The expression of insulin‐like growth factor (IGF)‐1 and runt‐related transcription factor 2 (Runx2) was significantly upregulated within the Ca + 40Sr treatment group; tumor necrosis factor (TNF)‐agr; expression was significantly downregulated in the Ca and Ca + 40Sr groups. The results indicate that Sr–Ca coadministration increases osteogenic gene expression and stimulates new bone formation. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27: 758–762, 2009
Micro‐Raman scattering spectroscopy study of Li‐doped and undoped ZnO needle crystals
Authors: Jothilakshmi R. , Ramakrishnan V. , Thangavel R. , Kumar J. , Sarua Andrei , Kuball Martin 
Published: November 2008

AbstractZnO nanostructures have attracted great attention for possible applications in optoelectronic and spintronic devices. The electrical resistivity because of carriers can be improved by the introduction of Li ions, as Li is a possible dopant for achieving p‐type ZnO. We have carried out a comprehensive micro‐Raman scattering study of the phonons in 1% Li‐ and undoped ZnO needle crystals grown and annealed at 1073 K for 1 and 2 h under oxygen environment. Phonon mode of doped and undoped ZnO does not show any measurable shift for the doping concentration of 1%. As line width is related to point defect density, we find for both Li‐ and undoped ZnO crystals the crystallinity is improving towards the tip of the needle crystals. Copyright © 2008 John Wiley & Sons, Ltd.
Is lymph node count an ideal quality indicator for cancer care?
Authors: Baxter Nancy N. 
Published: November 2008

AbstractAlthough lymph node count has substantial appeal as a quality indicator because of the ease of measurement, the presence of variation in the population, the association with survival for many cancers, and the previous success of quality intervention programs, improvements in patient outcome by increasing lymph node counts have not yet been demonstrated. This article discusses potential pitfalls in the use of lymph node count as a quality indicator. J. Surg. Oncol. 2009;99:265–268. © 2008 Wiley‐Liss, Inc.
Nationwide outcome registrations to improve quality of care in rectal surgery. An initiative of the European society of surgical oncology
Authors: van Gijn Willem , Wouters Michel W.J.M. , Peeters Koen C.M.J. , van de Velde Cornelis J.H. 
Published: November 2008

AbstractIn recent years there have been significant improvements in rectal cancer treatment. New surgical techniques as well as effective neoadjuvant treatment regimens have contributed to these improvements. Key is to spread these advances towards every rectal cancer patient and to ensure that not only patients who are treated within the framework of clinical trials may benefit from these advancements. Throughout Europe there have been interesting quality programmes that have proved to facilitate the spread of up to date knowledge and skills among medical professionals resulting in improved treatment outcome. Despite these laudable efforts there is still a wide variation in treatment outcome between countries, regions and institutions, which calls for a European audit on cancer treatment outcome. J. Surg. Oncol. 2009;99:491–496. © 2008 Wiley‐Liss, Inc.
Trimethylsilylation of Cellulose in Ionic Liquids
Authors: Mormann Werner , Wezstein Markus 
Published: November 2008

AbstractTrimethylsilylation of cellulose in different 1,3‐dialkylimidazolium ionic liquids (IL) with hexamethyldisilazane (HMDS) as a silylating agent was investigated. Trimethylsilyl (TMSi) cellulose with a degree of substitution (DS) greater than 1 is insoluble in the IL. The maximum DS obtained depends on the nature of the anion. Carboxylate and diethylphosphate counterions gave better results than chloride or thiocyanate, which corresponds to the solubility of HMDS in the IL. Controlled silylation with stoichiometric amounts of HMDS was feasible in imidazolium carboxylates and diethylphosphate. Analysis of the substitution pattern of the silyl groups in the anhydroglucose unit (AGU) by methylation analysis gave a more homogeneous distribution under (initially) homogeneous conditions (fewer unsubstituted AGUs, fewer trisubstituted AGUs) compared to TMSi cellulose obtained in liquid ammonia.magnified image