bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulation of fried spring roll wrapper quality upon treatment of batter with maltogenic amylase, transglutaminase and bromelain
Authors: Wang Jia‐Lin , Sun Meng‐Jin , Pei Zheng‐Meng , Zheng Zhi , Luo Shui‐Zhong , Zhao Yan‐Yan , Zhong Xi‐Yang 
Published: March 2024

AbstractBACKGROUNDFried foods are favored for their unique crispiness, golden color and flavor, but they also face great challenge because of their high oil content, high calories and the existence of compounds such as acrylamide and polycyclic aromatic hydrocarbons. Long‐term consumption of fried foods may adversely affect health. Therefore, it is necessary to explore fried foods with lower oil contents and a high quality to meet the demand.RESULTSA method of enzyme treatment was explored to investigate the effects of maltogenic amylase (MA), transglutaminase (TG) and bromelain (BRO) on the physicochemical properties of the batter and the quality of fried spring roll wrapper (FSRW). The results showed that the MA‐, TG‐ or BRO‐treated batters had a significant shear‐thinning behavior, especially with an increase in viscosity upon increasing TG contents. FSRW enhanced its fracturability from 419.19 g (Control) to 616.50 g (MA‐6 U g−1), 623.49 g (TG‐0.75 U g−1) and 644.96 g (BRO‐10 U g−1). Meanwhile, in comparison with BRO and MA, TG‐0.5 U g−1 endowed batter with the highest density and thermal stability. MA‐15 U g−1 and TG‐0.5 U g−1 displayed FSRW with uniform and dense pores, and significantly reduced its oil content by 18.05% and 25.02%, respectively. Moreover, compared to MA and TG, BRO‐50 U g−1 improved the flavor of FSRW.CONCLUSIONMA, TG or BRO played a key role in affecting the physicochemical properties of the batter and the quality of FSRW. TG‐0.5 U g−1 remarkly reduced the oil content of FSRW with a great potential in practical application. © 2024 Society of Chemical Industry.
Integrating mid‐infrared spectroscopy, machine learning, and graphical bias correction for fatty acid prediction in water buffalo milk
Authors: Yao Zhiqiu , Zou Wenna , Zhang Xinxin , Nie Pei , Lv Haimiao , Wang Wei , Zhao Xuhong , Yang Ying , Yang Liguo 
Published: March 2024

AbstractBACKGROUNDBuffalo milk, constituting 15% of global production, has higher fatty acids content than Holstein milk. Fourier‐transform mid‐infrared (FT‐MIR) spectroscopy is widely used for dairy analysis, but its application to buffalo milk, with larger fat globules, remains understudied. The ultimate goal of this study is to develop machine learning models based on FT‐MIR spectroscopy for predicting fatty acids in buffalo milk and to assess the accuracy of commercial milk analyzers. This research provides a convenient, fast, and environmentally friendly method for detecting the fatty acid composition in buffalo milk.RESULTSWe employed six machine learning algorithms to establish a detection model for 34 fatty acids in buffalo milk. The predictive models demonstrated robust capabilities for high‐content fatty acids [C14:0, C15:0, C16:0, C17:0, C18:0, C18:1, saturated fatty acid (SFA), monounsaturated fatty acid (MUFA)], with errors within a 15% range. Traditional FT6000 detection methods exhibited limitations in measuring SFAs and polyunsaturated fatty acids (PUFA). Implementing a mean difference correction of 0.21 for MUFAs and applying regression equations (SFA × 1.0639 + 0.0705; PUFA × 0.5472 + 0.0047) significantly improved measurement accuracy.CONCLUSIONThis study successfully developed a predictive model for fatty acids in Mediterranean buffalo milk based on FT‐MIR spectroscopy. Additionally, a correction was applied to the existing measurement device, FT6000, enabling more accurate measurements of fatty acids in buffalo milk. The findings have practical implications for the food industry, offering a faster and more reliable approach to assess and monitor fatty acid composition in buffalo milk, potentially influencing product development and quality control processes. © 2024 Society of Chemical Industry.
BPD Compass: Using a dimensional model of psychopathology to treat co‐occurring borderline personality disorder and posttraumatic stress symptoms
Authors: Hood Caitlyn O. , Southward Matthew W. , Badour Christal L. , Sauer‐Zavala Shannon 
Published: March 2024

AbstractBPD Compass is a transdiagnostic psychotherapy that includes cognitive, behavioral, and mindfulness skills targeting the personality dimensions of negative affectivity, disinhibition, and antagonism. Given considerable symptom comorbidity and overlap in etiology between borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD), this study investigated whether BPD Compass holds promise as an integrated approach to simultaneously treating co‐occurring BPD features and PTSD symptoms. Participants included 84 trauma‐exposed adults who participated in a two‐phase clinical trial (Phase 1: randomized controlled trial of BPD Compass vs. waitlist [n = 43]; Phase 2: open trial of BPD Compass [n = 41]). Compared to waitlist, BPD Compass led to medium‐to‐large–sized, significant improvements in BPD features, βs = −.57 −.44, and facets of neuroticism, βs < −.55–−.73, as well as small, nonsignificant improvements in self‐reported, β = −.20, and clinician‐rated PTSD symptom severity, β = −.19. During treatment, within‐person improvements in PTSD symptoms predicted subsequent improvements in BPD features, β = .13, but not vice versa, β = .07. Within‐person PTSD symptom reduction also predicted subsequent improvement in all personality dimensions, whereas only within‐person improvement in despondence, β = .12, affective dysregulation, β = .11, and dissociative tendencies, β = .12, predicted PTSD symptom reductions. Findings offer preliminary support for the potential of BPD Compass to target BPD features and aspects of neuroticism and agreeableness among trauma‐exposed adults. Moreover, PTSD symptom change predicting subsequent improvement in BPD features runs counter to current stage‐based treatment models that emphasize BPD feature stabilization before engaging in trauma‐focused therapy.
Impact of Procedural Variation in Endoscopic Dilation for Idiopathic Subglottic Stenosis
Authors: Santapuram Pooja , Tierney William S. , Huang Li‐Ching , Chen Sheau‐Chiann , Berry Lynn D. , Francis David O. , Gelbard Alexander 
Published: March 2024

ObjectivesA small number of Idiopathic subglottic stenosis (iSGS) patients are treated at institutions across the country. Divergence in operative techniques for endoscopic dilation (ED) of iSGS has been anecdotally recognized but not formally characterized. Additionally, the relationship between procedural variation and clinical outcome has not been studied.MethodsSecondary analysis of the NoAAC iSGS1000 cohort investigated variation in procedural techniques and treatment outcomes in patients treated with ED across high‐enrolling treatment centers (enrolled >10 patients in PR‐02 trial).ResultsThirteen NoAAC centers each enrolled >10 patients treated with ED for a total of 281 subjects. There was significant variation in procedural details and rate of recurrence among institutions. Hierarchal cluster analysis revealed significant heterogeneity among institutions and clusters in all procedural variables. However, analysis demonstrated a transient delay in disease recurrence in cluster 2 which disappeared with longer longitudinal follow‐up. Patient‐reported outcome and peak expiratory flow data supported the potential benefit of the technical variation in Cluster 2. Distinct to cluster 2, however, was routine use of adjuvant triple medical therapy (proton pump inhibitor (PPI), antibacterial agent, and steroid inhaler).ConclusionsBoth outcome and procedural technique vary among centers employing ED to treat iSGS. A transient delay in recurrence was observed among centers that routinely prescribed adjuvant medical therapy (antibiotic, inhaled corticosteroid, and PPI) to iSGS patients after endoscopic dilation, which was further supported by patient‐reported data and peak expiratory flow data. Prospective studies are needed to understand the effects of adjuvant medical therapy on recurrence after endoscopic dilation.Level of Evidence4 Laryngoscope, 134:3260–3266, 2024
Polydopamine as a Materials Platform to Promote Strong and Durable Interfaces in Thermoplastic Polymer‐Titanium Joints
Authors: Kafkopoulos Georgios , Duvigneau Joost , Vancso G. Julius 
Published: March 2024

AbstractJoining thermoplastic polymers (TPMs) and metals to form lightweight hybrid structures is of growing industrial and commercial importance. The performance of such materials relies on the bonding strength and endurance of the formed TPM–metal interfaces. The available joining technologies and the mechanisms that govern interfacial adhesion are reviewed in this contribution, highlighting thermal bonding as a commercially attractive joining method. By focusing on molecular interactions to optimize interfacial adhesion, the use of dopamine as a building block to form polydopamine (PDA) based adhesive interlayers in such interfaces is discussed. This work also highlights the potential of PDA to be applied as a load‐bearing adhesive—a notion considered to date unfeasible.
Deep‐subwavelength characteristics of focused vector double‐petal linear edge dislocation beams
Authors: Su Yu , Yang Chen , Yin Xiaojin , Guo Shanlong , Shi Pengbo , Li Jinhong 
Published: March 2024

AbstractRecently, vector beams with special intensity and phase distribution have received much attention due to their unique properties. In this paper, we construct the double‐petal linear edge dislocation (DPLED) beams based on Gaussian vortex beams. The distribution of intensity, polarization, and spin angular momentum (SAM) of the DPLED beams is analyzed in tightly focused based on the Richards‐Wolf vector diffraction theory. The significant difference is occurred in light field, polarization SAM, and polarization distributions before and after focusing of DPLED beams. It's of certain importance for expanding the application of vector beams in optical control, optical imaging, and other fields.
The effective perospirone augmentation with clonazepam for treatment‐resistant burning mouth syndrome: A case report
Authors: Watanabe Motoko , Takao Chihiro , Maeda Chizuko , Nayanar Gayatri , Tominaga Risa , Kimura Yasuyuki , Tu Trang Thi Huyen , Nagamine Takahiko , Toyofuku Akira 
Published: March 2024

AbstractBurning mouth syndrome (BMS) is characterized by burning sensations in the oral region without corresponding abnormalities and is often accompanied by uncomfortable sensations. Herein, we present cases of BMS in which the remaining uncomfortable sensations improved with perospirone augmentation with clonazepam. Case 1: A 61‐year‐old man complained of a burning pain in his tongue, a sensation of dryness and discomfort as if his tongue was sticking to a palatal plate. With the diagnosis of BMS, psychopharmacotherapy was initiated with amitriptyline. At the dose of amitriptyline 50 mg, the pain lessened but uncomfortable sensations persisted. Further attempts to alleviate symptoms by combining aripiprazole with amitriptyline, aripiprazole with mirtazapine, or aripiprazole with clonazepam were limited; however, nearly all symptoms were relieved by a combination of perospirone 8.0 mg with clonazepam 1.5 mg. Case 2: A 51‐year‐old woman complained of a burning sensation along with oral dryness and crumb‐like feeling on her tongue. She was diagnosed with BMS and began treatment with amitriptyline. Her burning sensation improved at the dose of 25 mg, but uncomfortable sensations persisted. Augmentation of amitriptyline with aripiprazole, aripiprazole either with valproate, mirtazapine, or clonazepam failed to produce a significant improvement. However, a regimen of perospirone 6.0 mg and clonazepam 1.5 mg relieved the crumb‐like sensation and pain and culminated in a stabilized condition. The reported cases suggested that multiple approaches targeting the dopaminergic circuit in basal ganglia involving the serotoninergic and GABA systems, through the administration of perospirone with clonazepam is an effective adjunctive treatment for the remaining uncomfortable sensations in patients with BMS.
Enhancing frequency regulation in multi‐area interconnected MPS with virtual inertia using MPC + PIDN controller
Authors: Vidyarthi Prabhat Kumar , Kumar Ashiwani 
Published: March 2024

AbstractThe challenge of controlling frequency deviation becomes more difficult as the complexity of a power network increases. The robustness of the controller has a major impact on the stability of a Modern Power system (MPS). Due to the hybridization of MPS basic AGC controllers (PID, FOPID, and TID) are insufficient to give optimal performance of a plant. This requires a robust controller. So, a novel MPC + PIDN controller has been proposed and evaluated by comparing it with several existing controllers, which gives optimal performance in terms of overshoot, undershoot, and settling time. A new modified Opposition‐based Sea‐horse Optimization (OSHO) method has been suggested to optimize the various controller settings. To demonstrate the OSHO's superiority, it is compared with a few popular, existing meta‐heuristic optimizations. The higher penetration levels of RESs reduced system inertia which further deteriorate frequency response in MPS. To overcome these challenges virtual inertia (VI) is implemented with MPC. VI is applied to improve the performance of the AGC of the interconnected MPS along with emphasizing the nature of intermittent renewable energy sources (RESs) of PV and wind energy. To determine the reliability and flexibility of the proposed controller, analysis has been done under a different situation, including step, random disturbances, and modified IEEE‐39 bus. Finally, the stability analysis is performed on a bode plot and the proposed results are compared with previously published literature. The extensive study demonstrates strong evidence that the suggested control approach is efficient and effective.
The Value of the Nutritional Indicators in Predicting Free Flap Failure From a Multicentre Database
Authors: Yen Yuan‐Hao , Luo Sheng‐Dean , Chen Wei‐Chih , Li Chung‐Yi , Chiu Tai‐Jan , Wang Yu‐Ming , Wu Shao‐Chun , Yang Yao‐Hsu , Chen Yung‐Hsuan , Wu Ching‐Nung 
Published: March 2024

AbstractObjectiveNutritional and inflammatory statuses have been associated with complications in microvascular‐free flaps during head and neck surgeries. This study aimed to evaluate the potential of nutritional indicators in predicting postoperative free flap complications.Study DesignWe conducted a 20‐year retrospective, case‐control study within a defined cohort.SettingThe study involved head and neck cancer patients from the Chang Gung Research Database who underwent simultaneous tumor ablation and free flap wound reconstruction between January 1, 2001, and December 31, 2019.MethodsWe employed logistic regression and stratified analysis to assess the risk of free flap complications and the subsequent need for flap revision or redo in relation to nutritional indicators and other clinical variables.ResultsOf the 8066 patients analyzed, 687 (8.5%) experienced free flap complications. Among these, 197 (2.4%) had free flap failures necessitating a redo of either a free flap or a pedicled flap. Beyond comorbidities such as chronic obstructive pulmonary disease, end‐stage renal disease, and a history of prior radiotherapy, every 10‐unit decrease in the preoperative prognostic nutritional index (PNI) was consistently associated with an increased risk of both free flap complications and failure. The covariate‐adjusted odds ratios were 1.90 (95% confidence interval [CI]: 1.42‐2.54) and 1.89 (95% CI: 1.13‐3.17), respectively.ConclusionA lower preoperative PNI suggests a higher likelihood of microvascular free flap complications in head and neck surgeries. Further randomized controlled trial designs are required to establish causality.
Fabrication of hyaluronic acid‐based nanoparticles and studies on their radical scavenging activity
Authors: Zhu Huiqing , Xu Suyue , Shang Guoshuo , Pan Xiaofei , Zhao Jingya , Zhao Bingqian , Sun Zeyu , Yang Xue , He Sisi , Xue Jintao 
Published: March 2024

AbstractThe purpose of this paper is to study the stability, radical scavenging activities, and bio‐safety of cysteine‐conjugated hyaluronic acid nanoparticles (Cys‐conj‐HA NPs). Additionally, the feasibility of utilizing these NPs as drug delivery systems is discussed. The structures of synthesized Cys‐conj‐HA polymers were analyzed using 1H nuclear magnetic spectrum (1H NMR) and Fourier transform infrared spectroscopy (FTIR) spectra. The stability, radical scavenging activity, and bio‐safety of fabricated Cys‐conj‐HA NPs were investigated. Transmission electron microscopy (TEM) photograph illustrated that Cys‐conj‐HA NPs possessed spherical shapes with an average diameter of approximately 230 nm. Furthermore, these NPs exhibited high stability at temperatures of 4, 25, and 37°C. Notably, Cys‐conj‐HA NPs demonstrated significant free radical scavenging capabilities. The high cell viability observed indicated the absence of cytotoxicity from Cys‐conj‐HA NPs. Additionally, bio‐safety studies revealed that these NPs did not induce acute toxicity in the blood and viscera of cargo‐free NPs treated mice. Elisa assays indicated that there was no significant difference in the concentrations of interferon‐γ (INF‐γ) and tumor necrosis factor‐α (TNF‐α) between Cys‐conj‐HA NPs and normal saline (NS) treated mice (ns, p > 0.05), suggesting the absence of an inflammatory reaction caused by these NPs. Consequently, it can be concluded that Cys‐conj‐HA NPs are sufficiently safe to be employed as a vehicle for delivering oxidizing drugs.
Thrombin‐targeted screening of anticoagulant active components from Polygonum amplexicaule D. Don var. sinense Forb by affinity ultrafiltration coupled with UPLC‐Q‐TOF‐MS
Authors: Huang Shiyi , He Xiangchang , Huang Chencun , He Weihe , Zhao Hongqing , Dai Jie , Xu Guangming 
Published: March 2024

AbstractIntroductionPolygonum amplexicaule D. Don var. sinense Forb (PAF), a medicinal plant, has the effect of promoting blood circulation and removing blood stasis. However, the active compounds and targets of its anticoagulant effect are still unclear.ObjectivesThis study aims to establish an effective reversely thrombin‐targeted screening method for anticoagulant active components in PAF by affinity ultrafiltration (AUF) coupled with ultrahigh‐performance liquid chromatography–quadrupole time‐of‐flight mass spectroscopy (UPLC‐Q‐TOF‐MS).MethodsDifferent polar parts of PAF were screened for potential thrombin ligands by AUF‐HPLC and identified by UPLC‐Q‐TOF‐MS. After studying the affinity between ligands and thrombin by molecular docking, the antithrombotic activity of ligands was detected in vivo by zebrafish thrombus model, and in vitro by chromogenic substrate method. The mechanism of such ligands on thrombin was further studied by coagulation factor assay.ResultsEleven potential thrombin ligands from PAF were screened by the AUF‐UPLC‐Q‐TOF‐MS method, and two compounds (butyl gallate and β‐sitosterol) with significant anticoagulant activity were discovered via in vitro and in vivo activity testing.ConclusionA method system based on AUF‐UPLC‐Q‐TOF‐MS, molecular docking and in vivo and in vitro experiments also provided a powerful tool for further exploration of anticoagulant active components in PAF.
Wearable and ingestible technology to evaluate and prevent exertional heat illness: A narrative review
Authors: Hintz Courtney N. , Butler Cody R. 
Published: March 2024

AbstractExertional heat illness remains a constant threat to the athlete, military service member, and laborer. Recent increases in the number and intensity of environmental heat waves places these populations at an ever increasing risk and can be deadly if not recognized and treated rapidly. For this reason, it is extremely important for medical providers to guide athletes, service members, and laborers in the implementation of awareness, education, and measures to reduce or mitigate the risk of exertional heat illness. Within the past 2 decades, a variety of wearable technology options have become commercially available to track an estimation of core temperature, yet questions continue to emerge as to its use, effectiveness, and practicality in athletics, the military, and the workforce. There is a paucity of data on the accuracy of many of these newer devices in the setting of true heat stroke physiology, and it is important to avoid overreliance on new wearable technology. Further research and improvement of this technology are critical to identify accuracy in the diagnosis and prevention of EHI.
Examination of changes in the breathing intolerance index to determine the respiratory support needs of very low birth weight infants
Authors: Mizogami Masae , Hasegawa Hisaya , Yamada Yosuke , Wasa Masanori , Ikeda Kenta 
Published: March 2024

AbstractBackgroundThe breathing intolerance index (BITI) is used to evaluate respiratory muscle tolerance. The higher the ratio of the inspiratory time to the total breathing time and the ratio of the tidal volume to the vital capacity, the more easily the respiratory muscles become fatigued. The BITI is high with chronic respiratory failure, and values of 0.15 or more indicate the need for assisted ventilation.ObjectiveThis study aimed to examine the changes in the BITI of very low birth weight infants (VLBWIs) and determine whether it is possible to use the BITI as an objective indicator of the timing of noninvasive respiratory support (NRS) withdrawal.MethodsVLBWIs admitted to our neonatal intensive care unit between July 2020 and July 2022 under NRS at 36 weeks’ postmenstrual age (PMA). If the BITI was less than 0.15, then we attempted to determine whether NRS could be withdrawn.ResultsSixteen infants with a median gestational age and birth weight of 30.9 weeks and 1249 g, respectively, were eligible. The median PMA at the time of the first examination was 36.6 weeks. The BITI of two VLBWIs was less than 0.15. For 11 of the other VLBWIs, the BITI decreased over time to less than 0.15 at 39 weeks’ PMA. After confirming that the BITI was less than 0.15, weaning from NRS was attempted. Weaning from NRS was possible except one VLBWI.ConclusionThe BITI can help evaluate respiratory tolerance and could be an objective indicator of the timing of NRS withdrawal.
Detection of insulin oligomeric forms by a novel surface plasmon resonance‐diffusion coefficient based approach
Authors: Calcagno Damiano , Perina Maria Luisa , Zingale Gabriele Antonio , Pandino Irene , Tuccitto Nunzio , Oliveri Valentina , Parravano Maria Cristina , Grasso Giuseppe 
Published: March 2024

AbstractInsulin is commonly used to treat diabetes and undergoes aggregation at the site of repeated injections in diabetic patients. Moreover, aggregation is also observed during its industrial production and transport and should be avoided to preserve its bioavailability to correctly adjust glucose levels in diabetic patients. However, monitoring the effect of various parameters (pH, protein concentration, metal ions, etc.) on the insulin aggregation and oligomerization state is very challenging. In this work, we have applied a novel Surface Plasmon Resonance (SPR)‐based experimental approach to insulin solutions at various experimental conditions, monitoring how its diffusion coefficient is affected by pH and the presence of metal ions (copper and zinc) with unprecedented sensitivity, precision, and reproducibility. The reported SPR method, hereby applied to a protein for the first time, besides giving insight into the insulin oligomerization and aggregation phenomena, proved to be very robust for determining the diffusion coefficient of any biomolecule. A theoretical background is given together with the software description, specially designed to fit the experimental data. This new way of applying SPR represents an innovation in the bio‐sensing field and expanding the potentiality of commonly used SPR instruments well over the canonical investigation of biomolecular interactions.