bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclic Mechanical and Fatigue Properties for Oil-Country-Tubular-Goods Materials
Authors: Kaiser T. M. V. , Yung V. Y. B. , Bacon R. M. 
Published: December 2008

Summary
This paper describes differences between actual material behavior and idealizations used for modeling purposes and discusses some of the implications for interpreting model predictions. Much of the design for well structures subjected to high-amplitude cyclic loading is based on material assumptions that extrapolate strength properties from uniaxial, tensile tests to conditions where multiaxial, cyclic stresses are imposed. This paper presents results from cyclic testing on a common oil-country-tubular-goods (OCTG) material and demonstrates differences between the physical behavior measured under cyclic loading conditions and theoretical behavior extrapolated by numerical modeling. Modeling theories for plastic deformation are discussed with their limitations and relevance in a cyclic-loading environment. The implications of these limitations for design choices in thermal wells also are discussed with example applications of cyclic material behavior and fatigue-life prediction.
Material fatigue properties for the high-amplitude, low-cycle application of thermal operations have not been investigated in much depth previously, particularly for OCTG. Along with characterizing cyclic mechanical properties, the tests discussed here also assessed the low-cycle fatigue properties of the sample OCTG steel. The consistent fatigue measurements, combined with analysis results using representative cyclic mechanical properties, can provide a basis for estimating fatigue life. Depending on analysis-model assumptions, substantial variation in predicted fatigue life can occur; therefore, exact fatigue-life predictions are not anticipated. The primary value in such modeling is in evaluating the relative effectiveness of mitigation options for extending well life.
Buoyancy-Dominated Multiphase Flow and Its Effect on Geological Sequestration of CO2
Authors: Bryant Steven L. , Lakshminarasimhan Srivatsan , Pope Gary A. 
Published: December 2008

Summary
We have previously proposed the "inject low and let rise" strategy of storing CO2 in deep saline aquifers. The idea is to maximize the amount of CO2 stored in immobile forms by letting CO2 rise toward the top seal of the aquifer but not reach it. The distance that the CO2 rises depends on the uniformity of the displacement front. In this paper, we address the question of whether the intrinsic instability of a buoyancy-driven immiscible displacement leads to fingering. Fingers could reach the top seal of the aquifer, leading to an accumulation of CO2 at large saturations. We study the mechanisms governing this type of displacement in a series of fine-grid numerical simulations. Each simulation begins with a finite volume of CO2 placed at large saturation at the bottom of a 2D aquifer. Only buoyancy forces drive the displacement. Boundaries are closed, so CO2 rises and brine falls as the simulation proceeds. Several fine-scale geostatistical realizations of permeability are considered, and the effects of capillary pressure, anisotropy, and dip angle are examined. In these simulations, buoyant instability has very little effect on the uniformity of the displacement front. Instead, the CO2 rises along preferential flow paths that are the consequence of spatially heterogeneous rock properties (permeability, drainage capillary pressure curve, and anisotropy). Capillary pressure broadens the lateral extent of the flow paths. If the formation beds are not horizontal, capillary pressure and anisotropy can cause the CO2 to move predominantly along the bedding plane rather than vertically. Accurate assessment of CO2 migration after injection ends will therefore require accurate characterization of the spatial correlation of permeability in the target formation and of the capillary pressure and relative permeability curves.
Anti‐Smudge Organic Afterglow Panels
Authors: Zhai Xiangxiang , Mo Zhe , Yan Qianqian , Zhao Yongliang , Wang Biaobing , Zhang Kaka 
Published: April 2024

AbstractOrganic afterglow panels show promising applications in display and information anti‐counterfeiting. Like other panels, organic afterglow panels are susceptible to contamination when used, which can affect their aesthetics and clarity. Here, a kind of visible‐light‐excitable anti‐smudge organic afterglow panels based on a dopant‐matrix strategy and easily prepared through the UV light‐curing method is reported. The phosphorescence lifetime of the panel is up to 9.45 s with an afterglow duration longer than 100 s. Moreover, the transparent panels with low dynamic friction (0.129), large water contact angle (108°) and oleic acid contact angle (77°), display high performance of anti‐smudge, water and oil repellency, and removability of fingerprints, avoiding the influence of ink or sewage on its aesthetics and clarity. This study will expand the pathways for practical applications of afterglow materials.
Field‐Free Memristive Spin–Orbit Torque Switching in A1 CoPt Single Layer for Image Edge Detection
Authors: Yang Liu , Li Wendi , Zuo Chao , Tao Ying , Jin Fang , Li Huihui , Tang RuJun , Dong Kaifeng 
Published: April 2024

AbstractWhile spin–orbit torque (SOT) devices are extensively investigated due to their potential for use in neural network computation, it remains challenging to explore the hardware for neural networks. In this paper, the field‐free memristive SOT switching of the CoPt single layer is used to propose a neuromorphic hardware circuit for detecting edges in images. Owing to its threefold symmetry of inversion, the polarity of SOT switching can be reversed by rotating the current by 60°. Moreover, the process of current‐induced SOT switching exhibits stable multi‐state magnetic switching behavior, and can be controllably tuned by using the pulse of the current. As the slope of the applied ramp pulse current increased, the wave of the anomalous Hall resistance changed from a curve with normally memristive property to trigonometric, and finally to cosine. The design of the hardware circuit for a single SOT device is subsequently formulated to detect the edges in images. The results of experiments verified the capability of this device to detect the edge lines in images with high accuracy, which confirms its potential for use in the hardware of neuromorphic computing platforms. The work here provides guidance for the application of SOT‐based devices to neuromorphic hardware.
Photoinduced Alkenylation of Alkenyl Sulfones with EDA Complexes between NHPI Esters and HE
Authors: Xu Mingli , Zhao Chenyue , Huang Yongxiang , Hu Shuo , Cheng Dongping , Xu Xiaoliang 
Published: April 2024

AbstractA novel alkenylation reaction between N‐hydroxyphthalimide (NHPI) esters and alkenyl sulfones is reported. It undergoes the formation of electron donor‐acceptor (EDA) complex and a series of alkenes are obtained in good to excellent yields. It has the advantages of simple operation, mild reaction conditions, and metal‐free.
Verknüpfung von Hochdruck‐Synthesegas‐Metallkatalyse und Biokatalyse in Tandem‐Eintopf‐Verfahren für die Synthese nicht‐chiraler und chiraler Alkohole aus Alkenen in Wasser
Authors: Bork Hannah , Naße Kim E. , Vorholt Andreas J. , Gröger Harald 
Published: April 2024

AbstractWährend simultan ablaufende Reaktionen zu den faszinierendsten Merkmalen der Biosynthese gehören, bietet dieses Konzept der Tandemprozesse auch ein großes Potenzial für die chemische Industrie im Hinblick auf eine geringere Abfallproduktion und eine verbesserte Prozesseffizienz und Nachhaltigkeit. Obwohl es Beispiele für chemoenzymatische Eintopf‐Synthesen gibt, ist die Kombination völlig unterschiedlicher Reaktionstypen zugleich selten. In diesem Beitrag zeigen wir, dass extreme „Antipoden“ der „Katalyse‐Welten“ wie die Synthesegas‐basierte Hochdruck‐Hydroformylierung und die biokatalytische Reduktion, welche beide als einzelne Reaktionen eine herausragende Rolle spielen, in einem Tandem‐artigen Eintopf‐Verfahren in Wasser kombiniert werden können. Hierbei wurde sowohl für den Biokatalysator als auch den Chemokatalysator keine signifikante Deaktivierung festgestellt. Ein Nachweis für die Machbarkeit eines solchen Eintopf‐Prozesses ausgehend von 1‐Octen wurde durch einen Umsatz von >99 % und einer isolierten Ausbeute von 80 % der gewünschten Alkoholisomere erbracht. Alle erforderlichen Komponenten für die Hydroformylierung und die Biokatalyse wurden von Anfang an im Reaktor vorgelegt. Dieses Konzept wurde mit der Durchführung der Hydroformylierung von Styrol und einer enzymatischen dynamisch‐kinetischen Racematspaltung im Tandem‐Modus auf die enantioselektive Synthese chiraler Produkte ausgeweitet, wobei dies zu einem exzellenten Umsatz von >99 % und einem Enantiomerenverhältnis von 91 : 9 für (S)‐2‐Phenylpropanol führte. Der gesamte Prozess verläuft in Wasser unter milden und energiesparenden Bedingungen sowie ohne die Erfordernis zur Isolierung von Zwischenprodukten.
One‐step preparation of highly conductive eutectogel for a flexible strain sensor
Authors: Fan Kaiqi , Peng Jiwei , Yang Wentong , Wang Xiaobo , Liu Sen , Cao Luxin , Sun Haijun , Zhang Xiaojing 
Published: April 2024

AbstractGels with excellent ionic conductivity and resilience to temperature extremes are sought in practical applications due to their potential for building flexible and wearable soft electronics. In this work, highly conductive eutectogels are fabricated by one‐step polymerization of (3‐acrylamidopropyl) trimethyl ammonium chloride in deep eutectic solvents (DESs). Owing to the ion‐conductive polymer networks facilitating ion conduction, these eutectogels exhibit a significant enhancement in ionic conductivity (27.1 mS cm−1), demonstrating an order of magnitude higher than that of pure DES. Furthermore, due to several unique properties of DES, these eutectogels exhibit excellent stretchability (>1000%), good adhesion, as well as nonflammability performance over a wide temperature range (−40 to 100°C). Moreover, the strain sensor based on the eutectogel shows a highly sensitive response (gauge factor = 6.92) to a broad strain range (from 450% to 550%), enabling the accurate and reliable detection of various human movements. Additionally, our findings reveal that the eutectogel‐based sensor displays a comparable pattern of response curves with negligible signal deterioration, even at extreme temperatures of −20 and 60°C. The results of this work will promote novel applications in the construction of flexible and safe devices.
Artificial neural networks for the accurate prediction of the thickness of fiber membranes prepared by airflow‐assisted electrostatic spinning
Authors: Ma Zhenfeng , Zheng Zhaoguang , Zeng Jun , Feng Guodong , Huang Yihua , Luo Wenhui , He Minyou , Cui Jiaming , Liang Yi‐Jun 
Published: April 2024

AbstractThe practical application of fiber membranes prepared by electrostatic spinning requires a uniform thickness. However, the parameters involved in the spinning process are highly complex, particularly when it comes to precise control over membrane thickness. Hence, achieving a consistent and homogeneous thickness for fiber membranes has posed significant challenges thus far. To accurately predict membrane thickness during the spinning process and ensure consistent outcomes, this study employed polyvinylidene fluoride as the raw material and optimized electrostatic spinning preparation using an innovative airflow‐assisted strategy. The as‐proposed preparation strategy effectively enhances the volatilization of solvents within the jet, also promotes jet stretching through assistance from airflow, resulting in a more stable and homogeneous fiber diameter. Additionally, COMSOL simulations were utilized to provide rational explanations for these findings. By collecting multiple process parameters, including positive voltage, liquid supply speed, winding speed, and solution concentration, this study has successfully developed an artificial neural network (ANN) that exhibits reliable predictive capabilities for membrane thickness. Notably, the model demonstrates a remarkable goodness‐of‐fit with an R2 value of 0.9981. Through the integration of ANN with electrostatic spinning technology, significant advancements have been achieved in accurately predicting and controlling the uniformity of electrostatically spun polymer fiber membranes.
New 2‐nitroimidazole‐N‐acylhydrazones, analogs of benznidazole, as anti‐Trypanosoma cruzi agents
Authors: Pitombeira Marcelly C. S. R. , Júnior Policarpo A. S. , Murta Silvane Maria Fonseca , Romanha Alvaro , Luccas Pedro H. , Nonato M. Cristina , Rocha Rafael E. O. , Ferreira Rafaela S. , da Silveira Flávia F. , Castelo‐Branco Frederico S. , Carvalho Alcione S. , Boechat Nubia 
Published: April 2024

AbstractChagas disease is a neglected tropical parasitic disease caused by the protozoan Trypanosoma cruzi. Worldwide, an estimated 8 million people are infected with T. cruzi, causing more than 10,000 deaths per year. Currently, only two drugs, nifurtimox and benznidazole (BNZ), are approved for its treatment. However, both are ineffective during the chronic phase, show toxicity, and produce serious side effects. This work aimed to obtain and evaluate novel 2‐nitroimidazole‐N‐acylhydrazone derivatives analogous to BNZ. The design of these compounds used the two important pharmacophoric subunits of the BNZ prototype, the 2‐nitroimidazole nucleus and the benzene ring, and the bioisosterism among the amide group of BNZ and N‐acylhydrazone. The 27 compounds were obtained by a three‐step route in 57%–98% yields. The biological results demonstrated the potential of this new class of compounds, since eight compounds were potent and selective in the in vitro assay against T. cruzi amastigotes and trypomastigotes using a drug‐susceptible strain of T. cruzi (Tulahuen) (IC50 = 4.3–6.25 µM) and proved to be highly selective with low cytotoxicity on L929 cells. The type I nitroreductase (TcNTR) assay suggests that the new compounds may act as substrates for this enzyme.
Efficient production of l‐glutathione by whole‐cell catalysis with ATP regeneration from adenosine
Authors: Zuo Siqi , Zhao Jiarun , Zhang Pengfei , Liu Wenqian , Bi Ke , Wei Peilian , Lian Jiazhang , Xu Zhinan 
Published: April 2024

Abstractl‐glutathione (GSH) is an important tripeptide compound with extensive applications in medicine, food additives, and cosmetics industries. In this work, an innovative whole‐cell catalytic strategy was developed to enhance GSH production by combining metabolic engineering of GSH biosynthetic pathways with an adenosine‐based adenosine triphosphate (ATP) regeneration system in Escherichia coli. Concretely, to enhance GSH production in E. coli, several genes associated with GSH and
l‐cysteine degradation, as well as the branched metabolic flow, were deleted. Additionally, the GSH bifunctional synthase (GshFSA) and GSH ATP‐binding cassette exporter (CydDC) were overexpressed. Moreover, an adenosine‐based ATP regeneration system was first introduced into E. coli to enhance GSH biosynthesis without exogenous ATP additions. Through the optimization of whole‐cell catalytic conditions, the engineered strain GSH17‐FDC achieved an impressive GSH titer of 24.19 g/L only after 2 h reaction, with a nearly 100% (98.39%) conversion rate from the added
l‐Cys. This work not only unveils a new platform for GSH production but also provides valuable insights for the production of other high‐value metabolites that rely on ATP consumption.
Sulfhydryl‐functionalized COF‐based electrolyte strengthens chemical affinity toward polysulfides in quasi‐solid‐state Li‐S batteries
Authors: Bi Linnan , Xiao Jie , Song Yaochen , Sun Tianrui , Luo Mingkai , Wang Yi , Dong Peng , Zhang Yingjie , Yao Yao , Liao Jiaxuan , Wang Sizhe , Chou Shulei 
Published: April 2024

AbstractFor lithium‐sulfur batteries (Li‐S batteries), a high‐content electrolyte typically can exacerbate the shuttle effect, while a lean electrolyte may lead to decreased Li‐ion conductivity and reduced catalytic conversion efficiency, so achieving an appropriate electrolyte‐to‐sulfur ratio (E/S ratio) is essential for improving the battery cycling efficiency. A quasi‐solid electrolyte (COF‐SH@PVDF‐HFP) with strong adsorption and high catalytic conversion was constructed for in situ covalent organic framework (COF) growth on highly polarized polyvinylidene fluoride‐hexafluoropropylene (PVDF‐HFP) fibers. COF‐SH@PVDF‐HFP enables efficient Li‐ion conductivity with low‐content liquid electrolyte and effectively suppresses the shuttle effect. The results based on in situ Fourier‐transform infrared, in situ Raman, UV–Vis, X‐ray photoelectron, and density functional theory calculations confirmed the high catalytic conversion of COF‐SH layer containing sulfhydryl and imine groups for the lithium polysulfides. Lithium plating/stripping tests based on Li/COF‐SH@PVDF‐HFP/Li show excellent lithium compatibility (5 mAh cm−2 for 1400 h). The assembled Li‐S battery exhibits excellent rate (2 C 688.7 mAh g−1) and cycle performance (at 2 C of 568.8 mAh g−1 with a capacity retention of 77.3% after 800 cycles). This is the first report to improve the cycling stability of quasi‐solid‐state Li‐S batteries by reducing both the E/S ratio and the designing strategy of sulfhydryl‐functionalized COF for quasi‐solid electrolytes. This process opens up the possibility of the high performance of solid‐state Li‐S batteries.
Redox‐Active Dihydrophenazine‐Based Macrocycle: Synthesis, Conformation‐Adaptive Behavior and Host‐Guest Complexation with Tetracyanoquinodimethane
Authors: Hong Qiong‐Yan , Huang Bin , Wu Meng‐Xiang , Xu Lin , Zhao Xiao‐Li , Shi Xueliang , Yang Hai‐Bo 
Published: April 2024

Comprehensive SummaryA novel macrocycle based on conformation‐adaptive and electron‐rich dihydrophenazine was designed and synthesized. On the one hand, the macrocycle showed host‐guest interactions with tetracyanoquinodimethane (TCNQ) driving by charge transfer interaction between them. Meanwhile, host‐guest complexation was accompanied by fluorescence quenching and conformational change of the macrocycle. On the other hand, the oxidation of the macrocycle resulted in its diradical cation analogue and induced the release of the guest molecule TCNQ, thereby accomplishing reversible binding dynamics. Therefore, this work well illustrates the chemical and structural versatility of dihydrophenazine in the synthesis of macrocycles and their host‐guest chemistry.
Electrochemical Cascade Annulation for the Synthesis of 3‐Sulfanylquinoline Derivatives Under Mild Conditions
Authors: Li Ke , Guo Ming‐Zhong , Chen Zhuo , Li Hao‐Ran , Guo Weisi , Li Ming , Zhang Lin‐Bao 
Published: April 2024

Comprehensive SummaryAn efficient electrochemical approach has been developed for the construction of 3‐sulfanylquinoline derivatives by treating phenylethynylbenzoxazinanones with disulfides in an undivided cell. The protocol provided a convenient route to functionalized quinolines with good functional group tolerance. Moreover, it does not require any metal catalysts or additives, furnishing a series of biological quinolines in moderate to good yields.
Russell Mechanism‐Mediated Cancer Therapy: A Minireview
Authors: Zhang Rufeng , Liu Xiaoyang , Wu Fu‐Gen 
Published: April 2024

AbstractThe Russell mechanism, proposed by Russell, is a cyclic mechanism for the formation of linear tetroxide intermediates, which can spontaneously produce cytotoxic singlet oxygen (1O2) independent of oxygen, suggesting its anticancer potential. Compared with other mainstream anticancer strategies, the Russell mechanism employed for killing cancer cells does not require external energy input, harsh pH condition, and sufficient oxygen. However, up till now, the applications of Russell mechanism in antitumor therapy have been relatively rare, and there is almost no summary of the Russell mechanism in the cancer therapy field. This minireview introduces the different metal elements‐based Russell mechanisms and the relevant research progress in Russell mechanism‐based cancer therapy in recent years. At the same time, we briefly discussed the current challenges and future development regarding the applications of Russell mechanism. It is hoped that this review can further expand the research of Russell Mechanism in the biomedical field, and inspire researchers to extend its application fields to antibacterial, antiinflammatory, and wound healing uses.
Safety and efficacy of belantamab mafodotin with pembrolizumab in patients with relapsed or refractory multiple myeloma
Authors: Suvannasankha Attaya , Bahlis Nizar , Trudel Suzanne , Weisel Katja , Koenecke Christian , Oriol Albert , Voorhees Peter M. , Alonso Aranzazu A. , Callander Natalie S. , Mateos María‐Victoria , Reddy Nishitha , Hakim Shawn , LaMacchia John , Patel Nashita , Williams Danaé , Jewell Roxanne C. , Zhou Xiangdong , Gupta Ira , Opalinska Joanna , Nooka Ajay K. 
Published: April 2024

AbstractBackgroundBelantamab mafodotin (belamaf) has shown promising antimyeloma activity in relapsed or refractory multiple myeloma (RRMM) as a single agent. It was hypothesized that its multimodal activity may be enhanced by programmed cell death protein 1 pathway inhibition and activation of T cell–mediated antitumor responses. This study investigated the efficacy and safety of belamaf with pembrolizumab in patients with RRMM.MethodsDREAMM‐4 (NCT03848845) was an open‐label, single‐arm, phase 1/2 study divided into dose‐escalation (part 1) and dose‐expansion (part 2) phases. Patients were ≥18 years old with ≥3 prior lines of therapy including a proteasome inhibitor, an immunomodulatory drug, and an anti‐CD38 agent. Patients received belamaf (2.5 or 3.4 mg/kg, part 1; 2.5 mg/kg, part 2) and 200 mg pembrolizumab for ≤35 cycles.ResultsOf 41 enrolled patients, 34 (n = 6 part 1, n = 28 part 2) who received 2.5 mg/kg belamaf plus pembrolizumab were included in this final analysis. Sixteen patients (47%) achieved an overall response. Minimal residual disease negativity was achieved in three of 10 patients who had very good partial response or better. Five of eight patients who had prior anti–B‐cell maturation antigen therapy achieved partial response or better, including two who had B‐cell maturation antigen–refractory disease. Common grade ≥3 adverse events were keratopathy (38%) and thrombocytopenia (29%). Despite belamaf‐related ocular events, quality‐of‐life measures remained stable over time. No new safety signals were observed.ConclusionsThe results of DREAMM‐4 demonstrated clinical activity and a favorable safety profile of belamaf plus pembrolizumab in patients with RRMM. This trial is registered at www.ClinicalTrials.gov as NCT03848845.