bluuebunny/crossref_metadata_2025_split huggingface dataset:
Musicians Detect Pitch Violation in a Foreign Language Better Than Nonmusicians: Behavioral and Electrophysiological Evidence
Authors: Marques Carlos , Moreno Sylvain , Luís Castro São , Besson Mireille 
Published: August 2007

Abstract
The aim of this study was to determine whether musical expertise influences the detection of pitch variations in a foreign language that participants did not understand. To this end, French adults, musicians and nonmusicians, were presented with sentences spoken in Portuguese. The final words of the sentences were prosodically congruous (spoken at normal pitch height) or incongruous (pitch was increased by 35% or 120%). Results showed that when the pitch deviations were small and difficult to detect (35%: weak prosodic incongruities), the level of performance was higher for musicians than for nonmusicians. Moreover, analysis of the time course of pitch processing, as revealed by the event-related brain potentials to the prosodically congruous and incongruous sentence-final words, showed that musicians were, on average, 300 msec faster than nonmusicians to categorize prosodically congruous and incongruous endings. These results are in line with previous ones showing that musical expertise, by increasing discrimination of pitch—a basic acoustic parameter equally important for music and speech prosody—does facilitate the processing of pitch variations not only in music but also in language. Finally, comparison with previous results [Schön, D., Magne, C., & Besson, M. The music of speech: Music training facilitates pitch processing in both music and language. Psychophysiology, 41, 341–349, 2004] points to the influence of semantics on the perception of acoustic prosodic cues.
Differentiating Morphology, Form, and Meaning: Neural Correlates of Morphological Complexity
Authors: Bozic Mirjana , Marslen-Wilson William D. , Stamatakis Emmanuel A. , Davis Matthew H. , Tyler Lorraine K. 
Published: August 2007

Abstract
The role of morphological structure in word recognition raises issues about the nature and structure of the language system. One major issue is whether morphological factors provide an independent principle for lexical organization and processing, or whether morphological effects can be reduced to the joint contribution of form and meaning. The independence of form, meaning, and morphological structure can be directly investigated using derivationally complex words, because derived words can share form but need not share meaning (e.g., archer-arch). We used an event-related functional magnetic resonance imaging paradigm to investigate priming between pairs of words that potentially shared a stem, where this link was either semantically transparent (e.g., bravely-brave) or opaque (e.g., archer-arch). These morphologically related pairs were contrasted with identity priming (e.g., mist-mist) and priming for pairs of words that shared only form (e.g., scandal-scan) or meaning (e.g., accuse-blame). Morphologically related words produced significantly reduced activation in left frontal regions, whether the pairs were semantically transparent or opaque. The effect was not found for any of the control conditions (identity, form, or meaning). Morphological effects were observed separately from processing form and meaning and we propose that they reflect segmentation of complex derived words, a process triggered by surface morphological structure of complex words.
Implicit Trustworthiness Decisions: Automatic Coding of Face Properties in the Human Amygdala
Authors: Engell Andrew D. , Haxby James V. , Todorov Alexander 
Published: August 2007

Abstract
Deciding whether an unfamiliar person is trustworthy is one of the most important decisions in social environments. We used functional magnetic resonance imaging to show that the amygdala is involved in implicit evaluations of trustworthiness of faces, consistent with prior findings. The amygdala response increased as perceived trustworthiness decreased in a task that did not demand person evaluation. More importantly, we tested whether this response is due to an individual's idiosyncratic perception or to face properties that are perceived as untrustworthy across individuals. The amygdala response was better predicted by consensus ratings of trustworthiness than by an individual's own judgments. Individual judgments accounted for little residual variance in the amygdala after controlling for the shared variance with consensus ratings. These findings suggest that the amygdala automatically categorizes faces according to face properties commonly perceived to signal untrustworthiness.
Proprioception Contributes to the Sense of Agency during Visual Observation of Hand Movements: Evidence from Temporal Judgments of Action
Authors: Balslev Daniela , Cole Jonathan , Miall R. Chris 
Published: August 2007

Abstract
The ability to recognize visually one's own movement is important for motor control and, through attribution of agency, for social interactions. Agency of actions may be decided by comparisons of visual feedback, efferent signals, and proprioceptive inputs. Because the ability to identify one's own visual feedback from passive movements is decreased relative to active movements, or in some cases is even absent, the role of proprioception in self-recognition has been questioned. Proprioception during passive and activemovements may, however, differ, and so to address any role for proprioception in the sense of agency, the active movement condition must be examined. Here we tested a chronically deafferented man (I.W.) and an age-matched group of six healthy controls in a task requiring judgement of the timing of action. Subjects performed finger movements and watched a visual cursor that moved either synchronously or asynchronously with a random delay, and reported whether or not they felt they controlled the cursor. Movement accuracy was matched between groups. In the absence of proprioception, I.W. was less able than the control group to discriminate self- from computer-produced cursor movement based on the timing of movement. In a control visual discrimination task with concurrent similar finger movements but no agency detection, I.W. was unimpaired, suggesting that this effect was task specific. We conclude that proprioception does contribute to the visual identification of ownership during active movements and, thus, to the sense of agency.
The Functional Neuroanatomy of Thematic Role and Locative Relational Knowledge
Authors: Wu Denise H. , Waller Sara , Chatterjee Anjan 
Published: August 2007

Abstract
Lexical-semantic investigations in cognitive neuroscience have focused on conceptual knowledge of concrete objects. By contrast, relational concepts have been largely ignored. We examined thematic role and locative knowledge in 14 left-hemisphere-damage patients. Relational concepts shift cognitive focus away from the object to the relationship between objects, calling into question the relevance of traditional sensory-functional accounts of semantics. If extraction of a relational structure is the critical cognitive process common to both thematic and locative knowledge, then damage to neural structures involved in such an extraction would impair both kinds of knowledge. If the nature of the relationship itself is critical, then functional neuroanatomical dissociations should occur. Using a new lesion analysis method, we found that damage to the lateral temporal cortex produced deficits in thematic role knowledge and damage to inferior fronto-parietal regions produced deficits in locative knowledge. In addition, we found that conceptual knowledge of thematic roles dissociates from its mapping onto language. These relational knowledge deficits were not accounted for by deficits in processing nouns or verbs or by a general deficit in making inferences. Our results are consistent with the hypothesis that manners of visual motion serve as a point of entry for thematic role knowledge and networks dedicated to eye gaze, whereas reaching and grasping serve as a point of entry for locative knowledge. Intermediary convergence zones that are topographically guided by these sensory-motor points of entry play a critical role in the semantics of relational concepts.
Modifying the Cortical Processing for Motor Preparation by Repetitive Transcranial Magnetic Stimulation
Authors: Terao Yasuo , Furubayashi Toshiaki , Okabe Shingo , Mochizuki Hitoshi , Arai Noritoshi , Kobayashi Shunsuke , Ugawa Yoshikazu 
Published: August 2007

Abstract
To investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on the central processing of motor preparation, we had subjects perform a precued-choice reaction time (RT) task. They had to press one of two buttons as quickly as possible after a go signal specifying both the hand to be used and the button to press. A precue preceding this signal conveyed full, partial, or no advance information (hand and/or button), such that RT shortened with increasing amount of information. We applied 1200 to 2400 pulses of 1-Hz rTMS over various cortical areas and compared the subjects' performances at various times before and after this intervention. rTMS delayed RT at two distinct phases after stimulation, one within 10 min and another with a peak at 20 to 30 min and lasting for 60 to 90 min, with no significant effects on error rates or movement time. The effect was significantly larger on left- than on right-hand responses. RT was prominently delayed over the premotor and motor cortices with similar effects across different conditions of advance information, suggesting that preparatory processes relatively close to the formation of motor output were influenced by rTMS. In contrast, the effect of rTMS over the supplementary motor area and the anterior parietal cortex varied with the amount of advance information, indicating specific roles played by these areas in integrating target and effector information. The primary motor area, especially of the left hemisphere, may take over this processing, implementing motor output based on the information processed in other areas.
Clinical decision making and the expected value of information
Authors: Willan Andrew R. 
Published: August 2007

Background The results of the HOPE study, a randomized clinical trial, provide strong evidence that 1) ramipril prevents the composite outcome of cardiovascular death, myocardial infarction or stroke in patients who are at high risk of a cardiovascular event and 2) ramipril is cost-effective at a threshold willingness-to-pay of $10 000 to prevent an event of the composite outcome. In this report the concept of the expected value of information is used to determine if the information provided by the HOPE study is sufficient for decision making in the US and Canada. Methods and results Using the cost-effectiveness data from a clinical trial, or from a meta-analysis of several trials, one can determine, based on the number of future patients that would benefit from the health technology under investigation, the expected value of sample information (EVSI) of a future trial as a function of proposed sample size. If the EVSI exceeds the cost for any particular sample size then the current information is insufficient for decision making and a future trial is indicated. If, on the other hand, there is no sample size for which the EVSI exceeds the cost, then there is sufficient information for decision making and no future trial is required. Using the data from the HOPE study these concepts are applied for various assumptions regarding the fixed and variable cost of a future trial and the number of patients who would benefit from ramipril. Conclusions Expected value of information methods provide a decision-analytic alternative to the standard likelihood methods for assessing the evidence provided by cost-effectiveness data from randomized clinical trials. Clinical Trials 2007; 4: 279—285. http://ctj.sagepub.com
Perspectives of clinical research coordinators on disclosing financial conflicts of interest to potential research participants
Authors: Friedman Joëlle Y , Sugarman Jeremy , Dhillon Jatinder K , DePuy Venita , Pierre Christine K , Dinan Michaela A , Allsbrook Jennifer S , Schulman Kevin A , Weinfurt Kevin P 
Published: August 2007

Background Disclosing financial interests to potential research participants during the informed consent process is one strategy for managing conflicts of interest. Given that clinical research coordinators are typically charged with administering the informed consent process, it is critical to understand their experiences, attitudes and beliefs regarding the disclosure of financial interests in research. Purpose To understand the role of clinical research coordinators in disclosing financial interests in research, and potential barriers to such disclosures. Methods We developed a survey designed to measure clinical research coordinators' awareness of financial interests in clinical research, previous experience with disclosing financial interests, comfort with answering questions about financial interests and barriers to disclosing financial interests to potential research participants. Next we conducted cognitive interviews with 10 clinical research coordinators to assess understandability and content validity and to further refine the survey. We then administered the survey to clinical research coordinators attending the 2006 Global Conference of the Association of Clinical Research Professionals. Results Among 300 clinical research coordinators who completed the survey, there was a general awareness of financial interests in research. Forty-one percent reported disclosing such financial interests to potential research participants, and 28% reported being asked about them. Greater comfort in responding to questions about financial interests was associated with previous experience with disclosure, previous experience answering questions about financial interests, and greater length of time obtaining informed consent. Respondents indicated that there were barriers to disclosure, including lack of information (76%) and that participants would not understand disclosures (26%). Limitations Possible sample bias due to using a convenience sample. Conclusions Making information about financial interests in research readily available to clinical research coordinators, as well as providing education and training, should facilitate the disclosure of financial interests in research to potential research participants during the informed consent process. Clinical Trials 2007; 4: 272—278. http://ctj.sagepub.com
Monitoring and reporting of the Women's Health Initiative randomized hormone therapy trials
Authors: Anderson Garnet L. , Kooperberg Charles , Geller Nancy , Rossouw Jacques E. , Pettinger Mary , Prentice Ross L. 
Published: August 2007

Background The Women's Health Initiative (WHI) randomized trial of estrogen plus progestin (E + P) was terminated early based on an assessment of harms exceeding benefits for disease prevention. The results contravened prevailing wisdom and a large body of literature regarding benefits of menopausal hormone therapy. The results and their interpretation have been the subject of considerable debate. Purpose/methods To describe the process of developing a trial monitoring plan, the key interim and final data, and to explain the choice of statistical methods used in trial monitoring and reporting. Results A formalized monitoring plan was developed using statistical methods that acknowledged protocol-defined design and analysis plans, input of monitoring board members especially regarding the role of various study outcomes, and multiple comparisons. Major early departures from design assumptions concerning treatment effects indicated a need for additional flexibility in safety monitoring. When the trials were stopped early, questions arose as to how closely the statistical methods in published reports should correspond to those defined by protocol or used in monitoring. Methods were selected to provide a simple and transparent summary of the primary results, with a cautious interpretation promoted by acknowledgement of multiple testing. Conclusions Developing a formal trial monitoring plan with a view towards influencing clinical practice is useful for creating consensus among DSMB members regarding the evidence that would justify stopping a trial and the framework to be used to address statistical complexities. Departures from design assumptions typically occur. These reinforce the role of the DSMB in exercising their judgment, and the judicious adaptation of these statistical guidelines in monitoring and reporting trials. In communicating the results in such circumstances, priority should be given to presenting as fair, accurate and transparent a view of the data and findings as current methods and technology allow.
Applying justice in clinical trials for diverse populations
Authors: Tilburt Jon , Ford Jean G. , Howerton Mollie W. , Gary Tiffany L. , Lai Gabriel Y. , Bolen Shari , Baffi Charles , Wilson Renee F. , Tanpitukpongse Teerath Peter , Powe Neil R. , Bass Eric B. , Sugarman Jeremy 
Published: August 2007

Background Considerable attention has focused on increasing clinical trial participation for members of “underrepresented groups”. However, doing so involves clarifying how to meet the demands of justice, or fairness, which provides the ethical mandate to enhance broad trial representation. Purpose To examine the ethical principle of justice as it applies to recruiting diverse populations to clinical trials representation. Methods In this paper, we analyse the conceptual and practical challenges in applying the principle of justice to clinical trials representation. Results Different facets of justice include demands for both fair outcomes and fair processes. Including both of these facets in clinical trials policy should not only promote access to trials, but also help to provide a framework to improve fairness in representation in clinical trials. Efforts to evaluate recruitment of representation should include outcome and process measures. Limitations The suggestions offered based on this conceptual analysis need to be tested empirically. Conclusions Those involved in the design, conduct and oversight of clinical trials should consider all of the facets of justice when assessing representation in clinical trials and attempt to balance fair access to trials with a fair process that may require protection from being unduly pressured to participate. Clinical Trials 2007; 4: 264—269; http://ctj.sagepub.com
Dose-finding in phase I clinical trials based on toxicity probability intervals
Authors: Ji Yuan , Li Yisheng , Nebiyou Bekele B. 
Published: August 2007

Background Most phase I clinical trials conducted at the M. D. Anderson Cancer Center use the algorithmic 3 + 3 design, despite the availability of more advanced model-based designs such as the continual reassessment method. Purpose Through simple statistical modeling and computing, we develop a dose-finding design that can be easily understood and implemented by non-statisticians. Methods We propose a beta/binomial Bayesian model and a probabilistic up-and-down rule that allow all possible dose-assignment actions to be tabulated in a spreadsheet. We have developed an Excel macro (available at http://odin.mdacc. tmc.edu/~yuanj) that generates trial monitoring tables, which contain the dose-assignment actions corresponding to various toxicity outcomes. Results The new design outperforms the 3 + 3 design and performs comparably to other model-based methods in the literature. Limitations The proposed method assumes that the observed toxicity is a binary variable and that toxicity increases with dose level. Conclusion The new dose-finding design enables physicians to readily determine dose assignments for new patients by referencing a trial monitoring table. Clinical Trials 2007; 4: 235—244; http://ctj.sagepub.com
Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis
Authors: Kantari Chahrazade , Pederzoli-Ribeil Magali , Amir-Moazami Omid , Gausson-Dorey Valérie , Moura Ivan Cruz , Lecomte Marie-Christine , Benhamou Marc , Witko-Sarsat Véronique 
Published: August 2007

AbstractProteinase 3 (PR3), a serine proteinase contained in neutrophil azurophilic granules, is considered a risk factor for vasculitides and rheumatoid arthritis when expressed on the outer leaflet of neutrophil plasma membrane and is the preferred target of antineutrophil cytoplasm autoantibodies (ANCA) in Wegener granulomatosis. ANCA binding to PR3 expressed at the surface of neutrophils activates them. Evidence is provided that neutrophil apoptosis induced significantly more membrane PR3 expression without degranulation (but no enhanced membrane CD35, CD66b, CD63, myeloperoxidase, or elastase expression). This observation was confirmed on cytoplasts, a model of granule-free neutrophils. We hypothesized that PR3 could interact with proteins involved in membrane flip-flop (eg, phospholipid scramblase 1 [PLSCR1]). PR3-PLSCR1 interaction in neutrophils was demonstrated by confocal microscopy and coimmunoprecipitation. In the RBL-2H3 rat mast-cell line stably transfected with PR3 or its inactive mutant (PR3S203A), PR3 externalization depended on PLSCR1, as shown by less PR3 externalization in the presence of rPLSCR1 siRNA, but independently of its serine-proteinase activity. Finally, apoptosis-externalized PR3 decreased the human macrophage-phagocytosis rate of apoptotic PR3 transfectants. Therefore, in addition to ANCA binding in vasculitis, the proinflammatory role of membrane PR3 expression may involve interference with macrophage clearance of apoptotic neutrophils.
The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans
Authors: Menzel Stephan , Jiang Jie , Silver Nicholas , Gallagher Joy , Cunningham Juliette , Surdulescu Gabriela , Lathrop Mark , Farrall Martin , Spector Tim D. , Thein Swee Lay 
Published: August 2007

Abstract
Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics of erythrocyte maturation and differentiation, we have investigated the influence of the HMIP locus on other hematologic parameters. Here we show a significant impact of HMIP variability on several types of peripheral blood cells: erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content in healthy individuals of European ancestry. These results support the notion that changes of F-cell abundance can be an indicator of more general shifts in hematopoietic patterns in humans.