bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of Factor VIII Inhibitor and F8 Gene Mutations in Persons with Hemophilia A from Benin
Authors: Baglo Tatiana , Zohoun Alban , Houssou Bienvenu , Massi Romaric , Guiwa Charlotte Orou , Anani Ludovic , Gazard Dorothée Kindé , Fall Awa Omar Touré 
Published: March 2024

Aim: determine the prevalence of a FVIII inhibitors and identify the genetic mutations associated with their development in beninese personne with hemophilia (PwH) A.
Study Design: this is cross-sectional descrptive study conducted from June 2022 to May 2023 in hemophilia treatment centers in Benin.
Methodology: Inhibitor screening was carried out systematically in all PwHs A receiving FVIII infusion through determination of the circulating anticoagulant index and the Nijmegen-Bethesda assay. The molecular study strategy used for the F8 gene associated with hemophilia A is dependent on the severity of the hemophilia. Other data were collected either from patients' responses to the questionnaire or by studying their medical records and the center's hemophilia registry.
Results: Of the 97 PwHs A followed up, 57 had been treated with FVIII infusion. Of these, 21 had developed inhibitors, representing a frequency of 36.8% of treated PwHs A and 43.75% of severe PwHs. None of the moderate or mild PwHs A had developed anti-FVIII antibodies. PwHs A with inhibitors had a median age of 11 years, ranging from 1 to 66 years. The Nijmegen-Bethesda test revealed 11 high responders and 10 low responders. Mutation analysis of the F8 gene revealed seven cases of intron 22 inversion, seven cases of nonsense mutations, three cases of deletion and one case of missense mutation. Mutations weren’t identified in three patients because their DNA did not amplify on long-distance PCR. In terms of therapy, immune tolerance induction wasn’t achieved in any of the 21 patients, but they are treated with emicizumab and bypass depending on the context.
Conclusion: Although a cross-sectional study with a limited sample size, this study provides valuable information on beninese PwHs A with inhibitors. The frequency of inhibitors is high in treated PwHs A, and almost all patients who have developed inhibitors have high-risk genetic mutations.
Productivity of Dry Direct Seeded Rice as Influenced by Herbicide Combinations
Authors: P. Spandana Bhatt. P  , Reddy P. Raghu Rami , Varma NRG , Babu TK , Krishna L. , Mohan YC , Ramprakash T. 
Published: March 2024

A field experiment was conducted during Kharif, 2022, in Institute of Rice Research, Rajendranagar, Hyderabad in Telangana state, India. Fourteen weed management practices were evaluated in a randomized complete block design, replicated thrice. Weed management in Dry DSR can be done by adopting mechanical/ Hand weeding at 20, 40, 60 DAS under labour available conditions. Under labour scarcity conditions PE application of Pendimethalin 38.4% + Pyrazosulfuron ethyl 0.85% ZC 900 + 20 g/ha (Ready mix) followed by Metsulfuron Methyl 10% + Chlorimuron ethyl 10% WP 4 g/ha + Cyhalofop Butyl 10% EC 75g/ha (Tank mix) PoE weed followed by mechanical weeding at 40-45 DAS is the best option. Other suitable Pre emergence herbicides that can be used are Pyrazosulfuron ethyl 10% WP 20 g/ha, Pendimethalin 38.4% + Pyrazosulfuron ethyl 0.85% ZC 900 + 20 g/ha (Ready mix) and Pendimethalin 38.7 % CS 677.25 g/ha. Post emergence application of Triafamone 20% + Ethoxysulfuron l0% WG 44+22.5 g/ha (Ready mix) and Penoxsulam 1.02 % + Cyhalofop-butyl 5.1% OD 135 g/ha (Ready mix) at 2-4 weed leaf stage.
A Study on the Vulnerability of Fruit Crop Growers to Climate Change in Kalyana Karnataka Region
Authors: Goutham Kumar M  , Mallikarjun Ningdalli , Kammar Shivanad , Basanayak Rajashekar 
Published: March 2024

Vulnerability of fruit crop growers due to climate change can be defined as the degree to which the growers are susceptible to or unable to cope with the adverse effects of climate change. An ex-post-facto research design was used for the study. The study was conducted in the Koppal and Bidar districts of Kalyana Karnataka during the year 2022-23, to analyse the climate change vulnerability of fruit crop growers. The total sample consisted of 80 fruit crop growers, comprising 40 mango growers and 40 guava growers from both districts, respectively. A well-structured interview schedule and the Climate Change Vulnerability Index (CVI) was used for the study, which comprised three components: exposure, adaptive capacity and sensitivity to climate change. The overall CVI was found to be 0.124, which indicated a moderate level of vulnerability of growers to climate change. The CVI of Koppal district was 0.144, and that of Bidar district was 0.105. This indicated that the growers in Koppal district were more vulnerable than those in Bidar district to climate change factors. It can be concluded that the socio-demographic and socio-psychological attributes of the farmers might have been influenced variably.
Impact of Climate Change Assessments on Horticultural Crop Dynamics in Tamil Nadu, India
Authors: Karthick R. , Arulmani K. , Ravi K. 
Published: March 2024

Aim: This study aims to analyze the dynamics of horticultural crop production in Tamil Nadu amidst climate change, focusing on trends, challenges, and opportunities across diverse agro-climatic zones, primarily considering variations in rainfall.
Data: The research utilizes comprehensive datasets spanning a decade (2012-13 to 2021-22) encompassing records of rainfall, horticulture cultivation area, and production. The study focuses on major horticultural crop categories, including fruits, vegetables, plantation crops, spices and condiments, medicinal and aromatic crops, and flowers.
Objective: (1) analyze compound annual growth rates of area, production, and productivity of key horticultural crops in Tamil Nadu, (2) conduct decomposition analysis over a decade for horticultural crops, and (3) assess climate change impact on agricultural production in Tamil Nadu focusing on rainfall patterns.
Methodology: The study utilizes various analytical tools, including Compound Annual Growth Rate (CAGR) analysis, percentage analysis, decomposition analysis, and the Cobb-Douglas production function. Secondary data from government publications, including the Season and Crop Report of Tamil Nadu and the Department of Horticultural and Plantation Crop Report of Tamil Nadu, are utilized for analysis.
Results: The analysis reveals intricate patterns influenced by climate variability, with certain zones demonstrating harmonious growth, while others contend with challenges related to cultivation and productivity. The decomposition analysis highlights the respective contributions of changes in cultivation area and crop yield to variations in production, underscoring the impact of climate change on agricultural dynamics. Additionally, the Cobb-Douglas production function analysis indicates significant effects of both rainfall and cultivation area on horticultural production, emphasizing the multifaceted nature of factors influencing production trends.
Effect of Currency Depreciation on Share Prices of Listed Agricultural Firms in Kenya
Authors: Kiprop Cyrus , Koskei Loice 
Published: March 2024

This paper sought to assess the effects of currency depreciation on share prices of listed Agricultural firms in Kenya in the recent past 2020- 2023. It adopted a descriptive correlational research design. The target population was all the six Agricultural companies listed at the NSE as of December 2023. Secondary data was collected from the Nairobi Securities Exchange and Central Bank for the period January 2020 and December 2023, data collected took a panel dimension thus a simple regression analysis was done to establish the extent of the relationship between variables. It is evident that the shilling has drastically depreciated against the dollar while stock prices exhibited a price increase. The paper found out that a unit change in exchange rates leads to a change in stock prices by 0.094. This means that stock prices increase by 9.49%. Thus a weak positive relationship between exchange rates and stock prices therefore exchange rates alone cannot be used to explain stock price volatility. This paper findings informs investors, portfolio managers, regulators, listed companies, financial institutions, and other market players. portfolio managers are better when they increase their positions in equity stocks when they forecast a depreciation of the foreign currency and consequently dispose of shares in their portfolio if they predict an appreciation of the foreign currency. Additionally the government of Kenya should also establish measures and policies to enhance the country’s agricultural exports as this will go a long way in improving the performance of its agricultural listed. Finally it recommends further studies on the topic since it considered only two variables; exchange rates and share prices over four years.
Using the h‐index to rank influential information scientistss
Authors: Cronin Blaise , Meho Lokman 
Published: May 2006

AbstractThe authors apply a new bibliometric measure, the h‐index (Hirsch, 2005), to the literature of information science. Faculty rankings based on raw citation counts are compared with those based on h‐counts. There is a strong positive correlation between the two sets of rankings. It is shown how the h‐index can be used to express the broad impact of a scholar's research output over time in more nuanced fashion than straight citation counts.
Inactivation of herpes simplex type 1 gene vector on immobilized metal affinity chromatography: Oxidative damage by hydroxyl free radicals and its prevention
Authors: Jiang Canping , Ataai Mohammad , Ozuer Ali , Krisky David , Wechuck James , Pornsuwan Soraya , Pourarian Fazard , Glorioso Joseph C. 
Published: May 2006

AbstractMetal catalyzed oxidation (MCO), which typically involves oxygen free radical generation, is an important pathway that leads to the deterioration of many biological molecules in solution. The occurrence of MCO in immobilized metal affinity chromatography (IMAC) systems and its potential for inactivating biological products has not been well recognized. In this study, we report the inactivation of herpes simplex virus type 1 (HSV‐1) gene therapy vector on immobilized cobalt affinity chromatography. We observed that purification of KgBHAT, an HSV‐1 mutant bearing cobalt affinity tags (HAT) on the surface, on an IDA‐Co2+ column using crude supernatant as starting material resulted in signification loss in virus infectivity (<5% recovery). Electron spin resonance (ESR) revealed that the virus inactivation was caused by hydroxyl free radicals generated from the interactions between cellular impurities and the metal ions on the column. Inclusion of 20 mM ascorbate, a free radical scavenger, in the chromatography mobile phase effectively scavenged the hydroxyl radicals and dramatically augmented the infectivity recovery to 70%. This finding is the first demonstration of oxygen free radical‐mediated biological inactivation in an actual IMAC purification and the way on how to effectively prevent it. © 2006 Wiley Periodicals, Inc.
Endovenous laser treatment for long saphenous vein incompetence
Authors: Sharif M A , Soong C V , Lau L L , Corvan R , Lee B , Hannon R J 
Published: May 2006

Abstract

Background
Endovenous laser treatment is a percutaneous technique used for the treatment of long saphenous vein (LSV) incompetence. This paper presents the results of an uncontrolled case series undertaken to assess the feasibility, safety and efficacy of this technique.

Methods
Some 145 incompetent LSVs in 136 patients with saphenofemoral reflux were treated with endovenous laser. The data were evaluated prospectively. Assessment was carried out at 1 week, 3 and 12 months for LSV occlusion and symptomatic relief.

Results
Primary procedural success was achieved in 124 (85·5 per cent) of 145 LSVs. Reasons for primary failure included failed cannulation, failure to pass the guidewire and patient discomfort. At 3 months' follow-up, 105 (89·7 per cent) of 117 veins were totally and nine (7·7 per cent) were partially occluded. At 12 months, 63 (76 per cent) of 83 veins were totally and 15 (18 per cent) were partially occluded. At this stage 73 (88 per cent) of 83 patients remained satisfied, but 26 (31 per cent) had residual or recurrent varicosities. Of these, only five required further treatment. Complications included saphenous nerve injury in one patient and superficial skin burns in a second.

Conclusion
Endovenous laser treatment for LSV reflux is safe and can be carried out under local anaesthesia in an outpatient setting with good patient satisfaction and low complication rates.
Effects of arterial pressure in an experimental isolated haemoperfused porcine kidney preservation system
Authors: Hosgood S , Harper S , Kay M , Bagul A , Waller H , Nicholson M L 
Published: May 2006

Abstract

Background
Normothermic preservation provides metabolic support to an ischaemically damaged organ before use as a kidney transplant. Optimal conditions for ex vivo preservation have not yet been established. This study examined the effects of arterial pressure on renal preservation using isolated haemoperfused kidneys.

Methods
An isolated organ preservation system, developed using cardiopulmonary bypass technology, was used to perfuse porcine kidneys with normothermic oxygenated blood. Groups of kidneys (n = 6) were perfused at a mean arterial pressure of 95, 75 or 55 mmHg.

Results
Kidneys perfused at the higher mean arterial pressures of 95 and 75 mmHg demonstrated improved renal function: mean(s.d.) area under the curve (AUC) for creatinine clearance 71(19) and 55(30) respectively versus 14(12) in the 55-mmHg group, P = 0·002; AUC for serum creatinine 938(140) and 1290(394) versus 2404(595), P = 0·003. The higher perfusion pressures were also associated with better acid–base homeostasis and improved renal haemodynamics.

Conclusion
Mean arterial pressures of either 95 or 75 mmHg were capable of sustaining physiological renal function, but kidneys in the 95-mmHg group demonstrated superior renal function overall.
The Theory of Non‐Cottrellian Diffusion on the Surface of a Sphere or Truncated Sphere
Authors: Thompson Mary , Wildgoose Gregory G. , Compton Richard G. 
Published: May 2006

AbstractA method is developed whereby spherical and other particles can be derivatised with electroactive species on their surface and then immobilised on the surface of an electrode. The chronoamperometric and voltammetric responses in the limit of reversible electrode kinetics are modelled using a theory of charge movement over the surface of the spheres where this movement is considered as a diffusional process. The model is extended to include different distributions of sphere radii and to model the scenario of truncated spheres resting on the electrode surface. It is found that a good estimation of the truncation angle can be found by fitting the experimental data with theoretical predictions.
Theoretical Investigation of the Decarbonylation of Acetaldehyde by Fe+ and Cr+
Authors: Zhao Lianming , Guo Wenyue , Zhang Rongrong , Wu Shujuan , Lu Xiaoqing 
Published: May 2006

AbstractWe report a comprehensive theoretical study on the decarbonylation of acetaldehyde by Fe+ and Cr+. Various intermediates, transition states, and products involved in the decarbonylation reactions are fully optimized at the B3LYP/6‐311+G(2df,2pd) level of theory. The potential energy surfaces (PESs) corresponding to [M,O,C2,H4]+⋅(M=Cr and Fe) are examined in detail using B3LYP and CCSD(T) methods, respectively. The validity of these theoretical methods is calibrated with respect to the available thermochemical data. Calculations suggest that the Cr+ mediated decarbonylation of acetaldehyde takes place in four steps on the sextet surface: encounter complexation, CC activation, aldehyde H‐shift, and nonreactive dissociation, in good accordance with the Co+ mediated decarbonylation of acetaldehyde [Zhao, Zhang, Guo, Wu, Lu, Chem. Phys. Lett. 2005, 414, 28], while for the Fe+/acetaldehyde system decarbonylation can occur on both the quartet and the sextet PESs. The quartet pathway, which experiences spin–orbit coupling between the two surfaces, is energetically more favorable; whereas along the sextet decarbonylation coordinate several high‐energy barriers are revealed. The theoretical results are compared with the experimental product kinetic energy and angular distributions of decarbonylation of acetaldehyde by Fe+ and Cr+ measured using a crossed‐beam technique [Sonnenfroh, Farrar, J. Am. Chem. Soc. 1986, 108, 3521].
Mapping ribosomal RNA transcription activity in the mouse eye
Authors: Qian Jiangchao , Lavker Robert M. , Tseng Hung 
Published: May 2006

AbstractAll cells must make ribosomes, in which rRNA transcription is the rate‐limiting step; however, some cells may require more ribosomes than others. Cell‐type specific regulation of rRNA synthesis has been largely ignored in the past, because of the inability to measure rRNA transcription rate in situ. Here we map rRNA transcription activity in individual cells in mouse ocular tissues detected by a novel in situ hybridization technique, which detects the full‐length transcripts (47S pre‐rRNA) as well as various rRNA processing intermediates. In the adult mouse eye, the corneal and lens epithelia and some retinal neurons contain a higher level of 47S pre‐rRNA and rRNA processing intermediates, which are regulated developmentally in neonates prior to eye opening. In the cornea and lens epithelia, the higher rRNA level of 47S rRNA correlates with cell proliferation, which is consistent with the notion that dividing cells require more protein synthesis. Interestingly, in some retinal neurons, the high level of 47S pre‐rRNA does not correlate with mature rRNA accumulation or protein synthesis, suggesting the existence of unappreciated biochemical needs of these cells. Developmental Dynamics 235:1984–1993, 2006. © 2006 Wiley‐Liss, Inc.
Glutamate leakage from a compartmentalized intracellular metabolic pool and activation of the lipoxygenase pathway mediate oxidative astrocyte death by reversed glutamate transport
Authors: Re Diane B. , Nafia Imane , Melon Christophe , Shimamoto Keiko , Goff Lydia Kerkerian‐Le , Had‐Aissouni Laurence 
Published: May 2006

AbstractAstrocytes have essential roles for neuron survival and function, so that their demise in neurodegenerative insults, such as ischemia, deserves attention. A major event of the cell death cascade in ischemia is the reversed operation of excitatory amino acid transporters (EAAT), releasing glutamate. Cytotoxicity is conventionally attributed to extracellular glutamate accumulation. We previously reported that mimicking such dysfunction by EAAT substrate inhibitors, whose uptake induces glutamate release by heteroexchange, triggers glutathione (GSH) depletion and oxidative death of differentiated astrocytes in culture. Here we demonstrate that astrocyte death, although correlated with glutamate release, is not resulting from high extracellular glutamate‐mediated toxicity. L‐glutamate per se was gliotoxic only at concentrations much higher than the maximum reached with the potent EAAT substrate inhibitor L‐trans‐pyrrolidine‐2,4‐dicarboxylate (PDC), and toxicity was lower. Moreover, high glutamate concentrations offered protection against PDC. Protection was also provided by L‐aspartate, which is both transported by EAAT and metabolized into glutamate, and by inhibiting glutamine synthetase, which uses transported glutamate to synthesize glutamine. Neither D‐aspartate, a metabolically inert EAAT substrate, nor compounds that can provide glutamate intracellularly but are not EAAT substrates offered protection. Interestingly, only the compounds providing protection prevented PDC‐induced GSH depletion. These data strongly suggest that reversed uptake‐mediated astrocyte death results from the leakage of glutamate from a compartmentalized intracellular metabolic pool specifically fuelled by EAAT, crucial for preserving GSH contents. In addition, we provide evidence for a minor contribution of the cystine‐glutamate antiporter xc− but a major role of the 5‐lipoxygenase pathway in this death mechanism. © 2006 Wiley‐Liss, Inc.
Complete epididymal separation presenting as polyorchidism
Authors: Zuppa Antonio Alberto , Nanni Lorenzo , Di Gregorio Flavio , Visintini Federica , Buonuomo Valentina , Pintus Claudio 
Published: May 2006

AbstractWe describe an unusual case of a 21‐month‐old boy with complete separation of the testis and epididymis. Two homogeneous structures were observed in the scrotum of a newborn boy in addition to a third structure. Polyorchidism was suspected, but follow‐up sonographic studies showed a decrease in the echogenicity of the left scrotal structure. Surgical exploration revealed the testis and epididymis to be completely separated, with no duplicated testis. Orchidopexy was then performed. © 2006 Wiley Periodicals, Inc. J Clin Ultrasound 34:258–260, 2006
Anterior sacral meningocele simulating ovarian cyst
Authors: Erdogmus Besir , Yazici Burhan , Ozdere Betul Ayca , Safak Alp Alper 
Published: May 2006

AbstractAnterior sacral meningocele is a rare condition characterized by the herniation of meningeal membranes and cerebrospinal fluid through a defect in the anterior aspect of the sacrum. We report a case of an anterior sacral meningocele that was mimicking an ovarian cyst. © 2006 Wiley Periodicals, Inc. J Clin Ultrasound 34:244–246, 2006
Sonographic diagnosis of a toothpick traversing the duodenum and penetrating into the liver
Authors: Chiang Tsung‐Hsien , Liu Kao‐Lang , Lee Yi‐Chia , Chiu Han‐Mo , Lin Jaw‐Town , Wang Hsiu‐Po 
Published: May 2006

AbstractIngested foreign bodies rarely cause gastrointestinal perforation, because the majority are passed out uneventfully in the feces. However, long, sharp, slender, hard, indigestible objects such as toothpicks are dangerous and may lead to potentially life‐threatening complications. We report a case of duodenal perforation caused by a toothpick and complicated by liver abscess and methicillin‐resistant Staphylococcus aureus sepsis. Although laparotomy was not performed because of the patient's refusal to undergo surgery, the liver abscess and sepsis were controlled successfully with antibiotics. We also conducted a literature search for reports on injuries caused by ingested toothpicks. © 2006 Wiley Periodicals, Inc. J Clin Ultrasound 34:237–240, 2006
Retroperitoneal neurilemoma diagnosed by endosonographically guided fine needle aspiration
Authors: Facciorusso Domenico , Federici Telemaco , Giacobbe Antonio , Niro Grazia Anna , Piermanni Vito , Andriulli Angelo 
Published: May 2006

AbstractRetroperitoneal neurilemoma is an often asymptomatic benign tumor that is usually discovered incidentally. We report a case of retroperitoneal neurilemoma diagnosed via endosonographically guided fine needle aspiration and emphasize the importance of obtaining a definite diagnosis before surgical treatment. © 2006 Wiley Periodicals, Inc. J Clin Ultrasound 34:241–243, 2006