bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development, testing and validation of a targeted NGS-panel for the detection of actionable mutations in lung cancer (NSCLC) using anchored multiplex PCR technology in a multicentric setting
Authors: Kumbrink Jörg , Demes Melanie-Christin , Jeroch Jan , Bräuninger Andreas , Hartung Kristin , Gerstenmaier Uwe , Marienfeld Ralf , Hillmer Axel , Bohn Nadine , Lehning Christina , Ferch Ferdinand , Wild Peter , Gattenlöhner Stefan , Möller Peter , Klauschen Frederick , Jung Andreas 
Published: March 2024

Lung cancer is a paradigm for a genetically driven tumor. A variety of drugs were developed targeting specific biomarkers requiring testing for tumor genetic alterations in relevant biomarkers. Different next-generation sequencing technologies are available for library generation: 1) anchored multiplex-, 2) amplicon based- and 3) hybrid capture-based-PCR. Anchored multiplex PCR-based sequencing was investigated for routine molecular testing within the national Network Genomic Medicine Lung Cancer (nNGM). Four centers applied the anchored multiplex ArcherDX-Variantplex nNGMv2 panel to re-analyze samples pre-tested during routine diagnostics. Data analyses were performed by each center and compiled centrally according to study design. Pre-defined standards were utilized, and panel sensitivity was determined by dilution experiments. nNGMv2 panel sequencing was successful in 98.9% of the samples (N = 90). With default filter settings, all but two potential MET exon 14 skipping variants were identified at similar allele frequencies. Both MET variants were found with an adapted calling filter. Three additional variants (KEAP1, STK11, TP53) were called that were not identified in pre-testing analyses. Only total DNA amount but not a qPCR-based DNA quality score correlated with average coverage. Analysis was successful with a DNA input as low as 6.25 ng. Anchored multiplex PCR-based sequencing (nNGMv2) and a sophisticated user-friendly Archer-Analysis pipeline is a robust and specific technology to detect tumor genetic mutations for precision medicine of lung cancer patients.
Identifikasi Tipologi Urban Sprawl Pinggiran Kota (Studi Kasus Di Kecamatan Kemiling, Bandar Lampung)
Authors: Asya Haarits Bramantya Putra 
Published: March 2024

Perkembangan wilayah memiliki dampak positif akan berkembang maju sosial ekonomi sedangkan dampak negatif akan mengalami kepadatan dan ketidakberaturan jika pedoman perencanaan tidak dilaksanakan dengan baik. Urban sprawl adalah perluasan diluar batas administrasi dikarenakan dampak perkembangan pada wilayah sekitarnya, dalam hal ini dengan mengambil lokasi studi kasus Kecamatan Kemiling dan Kelurahan Kurungannyawa. Penelitian ini menggunakan metode kuantitatif analisis spasial, analisis korelasi, dan scoring dengan data diperoleh bersumber pada kelurahan, kecamatan, dan citra satelit google earth. Hasil analisis diketahui lokasi studi kasus dengan jumlah 10 kelurahan/desa, 6 diantaranya mengalami sprawl, 4 diantaranya mengalami normal dan mendekati sprawl, hal tersebut berdasarkan indikator: kepadatan penduduk, kepadatan bangunan, jarak ke pusat kota, pembangunan dalam jangkauan jaringan jalan, dan pembangunan pola lompatan katak. Kemudian dilakukan perhitungan score indikator tiap kelurahan teridentifikasi sprawl, diperoleh 3 kelurahan termasuk tingkat tinggi, 2 kelurahan termasuk tingkat sedang, dan 1 kelurahan termasuk tingkat rendah, kemudian berdasarkan uji korelasi diperoleh jarak ke pusat kota memiliki korelasi terhadap perkembangan lahan terbangun.

Kata Kunci: Kepadatan Penduduk, Analisis Spasial, Faktor Sosial Ekonomi

Regional development has a positive impact on developing socio-economic progress while the negative impact will experience density and irregularity if planning guidelines are not implemented properly. Urban sprawl is an expansion beyond administrative boundaries due to the impact of development on the surrounding area, in this case by taking the location of the case study in Kemiling District and Kurungannyawa Village. This study uses quantitative methods of spatial analysis, correlation analysis, and scoring with data obtained from urban villages, sub-districts, and google earth satellite images. The results of the analysis show that the location of the case studies is 10 kelurahan/village, 6 of them experienced sprawl, 4 of them experienced normal and approaching sprawl, this is based on indicators: population density, building density, distance to the city center, development within the reach of the road network, and development frog jump pattern. Then the indicator score was calculated for each sprawl identified kelurahan, obtained 3 kelurahan including high level, 2 kelurahan including medium level, and 1 kelurahan including low level, then based on the correlation test obtained distance to city center have correlation to the development of built up land.

Keywords: Population Density, Spatial Analysis, Socioeconomic Factors
Kajian Strategi Branding UMKM Quiinz Bowl Bojongsoang sebagai Adaptasi Pasca Pandemic
Authors: Prahara Gema Ari 
Published: March 2024

The development of the post-pandemic culinary business has experienced various problems, especially for micro businesses. Problems exist in internal and external elements. In general, there is growth in the culinary sector on a local and regional scale. This problem is experienced by MSMEs Quiinz Bowl, a home-based business that continues to survive and continue to do business in the midst of a changing market. The Quiinz Bowl is trying to try to get out of the post-pandemic barrier. Even though demand is declining, this business is still looking for a way out that can maintain the existence of its micro business. The Quiinz Bowl uses a branding strategy in determining the way forward. This study uses qualitative methods with recommendations for branding strategy analysis implemented in concrete steps in visual communication media Branding strategy with the rejuvenation of previous visual characters is a step to trigger novelty. The use of instore media, is a solution used as an early stage of strengthening Quiinz Bowl products.
Visualisasi Muslim dalam Video Game sebagai Citra Islam dalam dunia Game. Studi Kasus : Call of Duty, Assassins Creed & Battlefield
Authors: Albar Deni 
Published: March 2024

Secara ekonomi, pasar game global menghasilkan keuntungan sekitar 2 triliun rupiah pada tahun 2020. Separuh dari pendapatan tersebut berasal dari kawasan Asia Pasifik. Dalam video game terdapat pesan-pesan yang disampaikan kepada para pemainnya, pesan tersebut dapat berupa ideologi, politik, ekonomi, sosial dan budaya. Salah satu pesan dalam dunia game yang menarik untuk dikaji adalah citra umat Islam dalam dunia game yang dikembangkan oleh developer dari Barat atau Eropa yang menampilkan bias budaya, terutama sejak peristiwa 9/11 di Amerika Serikat hingga perkembangannya pada tahun 2022. Hal in menjadi urgensi penelitian terhadap kerukunan beragama yang dipengaruhi oleh citra dalam game. Penelitian ini bertujuan untuk menemukan rumusan konseptual dalam penerapan pencitraan suatu agama khususnya Islam dalam media game. Penelitian ini berorientasi pada penjelasan dalam mengantisipasi fenomena/gejala religi dalam mendukung proses penerapannya dalam dunia game. Metode yang digunakan dalam penelitian ini adalah penelitian kualitatif deskriptif dengan metode data kepustakaan. Penelitian ini dilakukan dengan mengkaji representasi visual dari simbol visual agama Islam dalam berbagai video game, khususnya video game yang dikembangkan oleh developer barat, kemudian mengaitkannya dengan gameplay dalam game tersebut. Deskripsi menggunakan fakta-fakta dari data yang diperoleh sebagaimana adanya. Hasil penelitian ini diharapkan mampu menunjukkan rumusan konsep dalam merepresentasikan Islam dalam dunia game dan menjadi acuan yang tepat dalam penerapannya.
Determining the Usage Properties of Some Natural Substrate Materials in submerged macrophyte Vallisneria sp. culture
Authors: Öz Meryem 
Published: March 2024

In this research, which targets removing nutrients resulting from the metabolic wastes of fish and unconsumed feed from the environment in aquarium systems where fish, plants, and ground material are used in the same environment and use them as plant nutrients, it was aimed to determine the usage properties of zeolite, leonardite and diatomite materials on the growth parameters of the Vallisneria sp. plant.
The study was conducted in three stages for 8 months. The first step of the study was planned as the plant adaptation phase, and no fish were added to the environment. In the second step, fish was introduced. The third step was designed to determine the adsorbent mixture's plant nutrient storage capacity (effective usage period). In the experimental aquariums, no plant nutrient or fertiliser other than fish food was used at all stages. The effects and using duration on the growth of the Vallisneria sp plant of adsorbed nutrients from unconsumed feed by leonardite and zeolite mixture were investigated in three stages in aquarium condition. Trial groups were formed by adding the adsorbent mixture of the feed having a 40% protein value to the first group (G1), the adsorbent mixture of the feed having a 33% protein value to the second group (G2), and the adsorbent mixture without feed to the third group (G3).
When the SGR values at the end of the experiment were compared, there was no statistical difference between the G1 and G2 groups, which contained 40% and 33% protein (P>0.05). On the other hand, both groups (G1, G2) showed significantly higher (P
Urgensi Perlindungan Hukum terhadap Konsumen Lembaga Pinjaman Online Ilegal di Era Revolusi 4.0
Authors: Rahmad Tedi Sutadi , Situmeang Ampuan , Girsang Junimart 
Published: March 2024

Online lending institution is a product of the 4.0 revolution. Its emergence has had many positive impacts on the economy, but on the other hand it has also raised several problems including misuse of personal data, intimidating collecting, and other problems caused by unlicensed or illegal online lending institutions. This study aims to identify the urgency of legal protection for consumers of illegal online lending institution.The method used in this study is normative juridical method by examining library materials or secondary data. The results showed that there are substance problems in legal protection for consumers of illegal online loan institutions in the era of revolution 4.0 which has implications for the ineffectiveness of existing regulations. Therefore, it is urgent to form new regulations that are able to regulate specifically, firmly, and thoroughly so as to create responsive laws, in order to create comfort and security for consumers of online lending institutions in Indonesia.
PERBEDAAN TINGKAT PENGETAHUAN, SIKAP DAN PERILAKU TERHADAP PENCEGAHAN COVID-19 ANTARA PENYINTAS DENGAN NON PENYINTAS COVID-19 DI KOTA KUPANG
Authors: Angi Stevanii Isabella , Hutasoit Regina , Buntoro Ika Febianti 
Published: March 2024

Pengetahuan yang benar dapat menjadi kunci bagaimana seseorang dapat melakukan tindakan pencegahan COVID-19 yang benar sehingga mengurangi risiko terinfeksi. Untuk mengetahui seberapa efektifnya pengetahuan terhadap resiko penularan infeksi maka peneliti tertarik untuk melakukan penelitian tentang perbedaan tingkat pengetahuan, sikap dan perilaku penyintas COVID-19. Tujuan penelitian ini untuk Mengetahui Perbedaan Tingkat Pengetahuan, Sikap dan Perilaku Terhadap Perilaku Pencegahan COVID-19 Antara Penyintas dengan Non Penyintas COVID-19 di Kota Kupang. Metode penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross sectional. Teknik pengambilan sampel dilakukan menggunakan non-probability sampling yaitu jenis accidental sampling dengan jumlah sampel sebanyak 265 responden yang memenuhi kriteria inklusi yaitu bersedia mengisi kuesioner, merupakan masyarakat berdomisili Kota Kupang, sudah ataupun belum pernah terdiagnosa COVID-19, berusia 17- 64 tahun, dan mampu menggunakan aplikasi google form. Penelitian dianalisis secara univariat menggunakan tabel distribusi frekuensi dan analisis bivariat menggunakan uji Wilcoxon. Hasil penelitian pada variabel tingkat pengetahuan pengetahuan didapati responden penyintas dengan pengetahuan tinggi sebanyak 206 orang( 78%), pengetahuan sedang 57(21,5%), dan pengetahuan rendah 2 orang (0,5%).Variabel sikap didapati sikap baik 137 orang (51,7%), cukup (46,5%), dan kurang (1,8%). Dan variabel perilaku didapati perilaku baik orang (241%), perilaku kurang orang (24%). Hasil uji bivariat menggunakan uji wilcoxon analisis perbedaan tingkat pengetahuan diperoleh hasil p= 0, 482 (p>0,05) untuk analisis perbedaan sikap diperoleh hasil p = 0,572 (p>0,05) sedangkan untuk analisis perbedaan perilaku diperoleh hasil p= 0,000 (p< 0,05). Kesimpulan penelitian tidak terdapat perbedaan yang signifikan dari pengetahuan dan sikap tetapi terdapat perbedaan yang signifikan pada perilaku antara penyintas dan non penyintas COVID-19 di Kota Kupang.
Hubungan Pengetahuan Dan Sikap Dengan Perilaku Pencegahan Covid-19 Pada Tenaga Kesehatan Di FKTP Nusa Tenggara Timur
Authors: Amalia Annisa , Lada Christina Olly , Sidarta Sagita , Wungouw Herman 
Published: March 2024

Latar Belakang : World Health Organization (WHO) mengumumkan COVID-19 sebagai pandemik pada tahun 2020. COVID-19 adalah penyakit yang sangat mudah menular namun dapat dicegah dengan cara penanganan yang tepat. Pengetahuan dan sikap serta perilaku tentang cara penaganan COVID-19 adalah hal yang perlu diperhatikan oleh tenaga kesehatan, hal tersebut dapat berdampak besar dalam melindungi tenaga kesehatan dari terpapar dan menurunkan angka kematian tenaga kesehatan sehingga membantu dalam menghadapi pandemi COVID-19.
Tujuan : Untuk mengetahui hubungan pengetahuan dan sikap dengan perilaku pencegahan COVID-19 pada tenaga kesehatan di FKTP Provinsi Nusa Tenggara Timur.
Metode : Penelitian ini merupakan penelitian analitikal observasional dengan rancangan cross sectional pada tenaga kesehatan di Nusa Tenggara Timur. Penentuan besar sampel diukur menggunakan rumus analitik korelatif dan mendapat hasil yaitu 243 responden. Sebanyak 243 responden yang memenuhi kriteria inklusi, serta bersedia diminta mengisi kuisioner pengetahuan sebanyak 16 pertanyaan, sikap sebanyak 15 pertanyaan dan perilaku sebanyak 14 pertanyaan tentang pencegahan COVID-19. Data dari responden akan di ekslusi apabila tidak mengisi kuisoner secara lengkap dan melakukan pengisian kuesioner dengan identitas yang sama. Penelitian ini dianalisis secara univariat kemudian bivariat menggunakan uji Kendall Tau..
Hasil : Dari 243 responden,didapati semua responden memiliki pengetahuan tinggi. Pada sikap terdapat 98,8% memiliki sikap baik dan 1,2% dengan sikap kurang baik. Pada perilaku terdapat 97,1% memiliki perilaku baik dan 2,9% dengan perilaku kurang baik. Hasil uji bivariat menggunakan uji Kendall Tau untuk hubungan antara Pengetahuan dengan Perilaku diperoleh hasil p=0,001 (p<0,05) dan untuk hubungan antara Sikap dengan Perilaku diperoleh hasil p=0,002 (p<0,05).
Kesimpulan : Terdapat hubungan yang signifikan antara pengetahuan dan sikap dengan perilaku pencegahan COVID-19 pada tenaga kesehatan di Nusa Tenggara Timur.
THE INFLUENCE OF REWARD, PUNISHMENT AND MOTIVATION ON EMPLOYEE WORK PRODUCTIVITY AT PT TANI SEJATI MANDIRI MALANG
Authors: Rindi Anisa Putri Nava , Nugraha Alifian 
Published: March 2024

One of the aspects that is important for a corporate organization is employee work productivity. Corporate performance is assessed as good with a high level of productivity, and vice versa if it is assessed as poor with a low level of productivity. Some of the main efforts to achieve optimal work productivity include training and motivation. The aim of this research is to determine the effect of reward, punishment, and motivation on employee work productivity. This is quantitative research with an explanatory (cause-and-effect) approach. The population in this study were all 34 employees of PT Tani Sejati Mandiri Malang. Sampling in this study used a saturated sampling technique. The analytical method used is multiple linear regression with SPSS 26 software. From the overall hypothesis, it shows that reward partially influences employee work productivity, punishment partially influences employee work productivity, and motivation does not partially influence employee work productivity. Reward, punishment, and motivation have a simultaneous influence on employee work productivity. It can be concluded that reward, punishment, and motivation have a significant effect on employee work productivity at PT Tani Sejati Mandiri Malang. An increase in employee work productivity can have an impact on business progress.
Keyword : Reward, Punishment, Motivation, Employee Productivity, Multiple Linear Regressi
A study on the resist performance of inorganic-organic resist materials for EUV and electron-beam lithography
Authors: Yamamoto Hiroki , Ito Yuko Tsutsui , Okamoto Kazumasa , Shimoda Shuhei , Kozawa Takahiro 
Published: March 2024

Abstract
In the realization of further miniaturization at scales of 10 nm and below in semiconductor devices, it is essential to create new resist designs, such as hybrid inorganic-organic resist materials for ionizing radiation, in order to clarify the effect the structure of metal resist on resist performance. In this study, some hybrid inorganic-organic resist materials known as metal-oxo clusters were synthesized, and their lithographic characteristics were investigated to clarify the relationship between resist performance, such as sensitivity, resolution, and their absorption coefficient or cross section, and the density of their elements by using EUV and electron-beam (EB) exposure. Our results indicated that the sensitivity in Hf-based oxo clusters was higher than that of Ti-based and Zr-based oxo clusters in both EB and EUV exposure. Although the exposure dose was not optimized, the patterns of Ti-based, Zr-based, and Hf-based oxo clusters showed 100, 50, and 32 nm line-and-space patterns at doses of 250, 80, and 25 μC cm−2, respectively. We clarified that it is very important for new resist designs such as hybrid inorganic-organic resists to increase the photo-absorption cross section and density of elements for EUV and EB without degradation of film quality. In addition, the size and homogeneity of the building blocks and film quality are very important for the resist performance of hybrid inorganic-organic resist materials. Furthermore, it is clarified that the etch durability of metal-oxo clusters is higher than conventional resist materials, and this is much increased by annealing them at 800 °C.
The fabrication of spin transfer torque-based magnetoresistive random access memory cell with ultra-low switching power
Authors: Yang Chengchang , Zou Sinan , Chen Xu , Gao Jianfeng , Liu Weibing , Yang Meiyin , Xu Jing , Kang Jin , Bu Weihai , Zheng Kai , Cui Yan , Luo Jun 
Published: March 2024

Abstract
We conducted research on the integration technology of a spin transfer torque-based magnetoresistive random access memory (STT-MRAM) cell (one transistor, one magnetic tunnel junction – 1T-1MTJ) on an 8-inch process platform. By combining a 0.5 μm CMOS front end of line process and STT-MTJ back end of line process, a 1T-1MTJ device with an MTJ of approximately 80 nm is realized. The Resistance(R)-magnetic field(H) measurement reveals a coercive force of approximately 450 Oe for the MTJ. Nevertheless, the 1T-1MTJ device exhibits a critical switching current of 4.7 μA (from high to low resistance state) and 17.9 μA (from low to high resistance state), accompanied by corresponding critical switching voltages of 0.05 V and 0.16 V, respectively, which is extremely low in an STT-MRAM with dual CoFeB/MgO interface free layer. Our findings demonstrate the potential for application in ultra-low-power portable mobile devices and embedded systems.
Sistem Informasi Pelayanan Administrasi Desa Genting Berbasis Web
Authors: Heru Heru Aji Pangestu , Kirman  , Sri Handayani  
Published: March 2024

Abstrak— Proses pelayanan surat-menyurat di kantor desa genting masih menggunakan cara konvensional. Proses pelayanan dan pencatatan surat-menyurat dilakukan dengan manual dimana data surat yang telah dibuat masih dicatat pada sebuah buku, sehingga rentan untuk rusak dan tercecer ketika disimpan dalam jangka waktu yang lama. Dalam pencarian data surat yang telah buat juga sering terjadi kesulitan karena data yang sangat banyak dan sering hilang. Tujuan dari penelitian ini adalah membuat website desa yang nantinya dapat di pergunakan oleh pemerintah desa sebagai media informasi desa, sehingga masyarakat desa khususnya dan masyarakat luas umum dapat mengakses informasi tentang desa genting. Pada penelitian ini metode pengembangan sistem menggunakan Incremental Model, perancangan sistem menggunakan conteks diagram, data flow diagram (DFD), dan Entity Relationship Diagram (ERD) dan metode pengujian sistem menggunakan blackbox testing . Hasil pengujian Sistem Informasi Pelayanan Administrasi Desa Genting Berbasis Web berdasarkan hasil pengujian dari sistem pelayanan administrasi desa berbasis website sesuai yang diharapkan berdasarkan 3 variabel, yaitu, penilaian pada variabel tampilan termasuk kategori “Sangat Baik”, penilaian pada variabel kemudahan pengguna termasuk kategori “Sangat Baik” dan penilaian pada variabel kinerja sistem termasuk kategori “Baik”.
Relationship Between Serum Malondialdehyde (MDA) Levels With Seizure Frequency In Epilepsy Patients With Combination Of Phenytoin And Valproic Acid
Authors: Noegroho Aji , Bintoro Aris Catur , Pudjonarko Dwi 
Published: March 2024

Background: Oxidative stress is believed to be one of the factors involved in the pathogenesis of epileptogenic where lipid peroxidation occurs which produces Malondialdehyde (MDA). Epilepsy and some Antiepileptic Drugs (AEDs) can improve or worsen seizure frequency thereby significantly changing blood MDA levels.

Objective: To determine the relationship between serum MDA levels and seizure frequency in epileptic patients treated with AEDs, a combination of phenytoin and valproic acid.

Methods: A cross-sectional study with consecutive sampling of 46 subjects (with epilepsy receiving combination therapy with phenytoin and valproic acid. The research was conducted at the Neurology Policlinic at RSUP Dr. Kariadi in December 2022 – February 2023. MDA levels were measured using the Enzyme Linked Immunosorbent Assay (ELISA) method. The relationship between serum MDA levels and seizure frequency was analyzed using Spearman's test since both of the variables are ordinal scale, the results were significant if p<0.05.

Results: There was no relationship between MDA levels and seizure frequency in epileptic patients with the combination of phenytoin and valproic acid. (p=0.516) There is a significant relationship between the frequency of seizures and the length of treatment (p=0.026) with a weak negative correlation (rho=0.328). There is a significant relationship between the frequency of seizures and the age of onset of epilepsy (p=0.037) with a weak negative correlation (rho=0.309).
Conclusion: There is a significant relationship between the frequency of seizures with the length of treatment and the age of onset of epilepsy.