bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and Structures of Multicomponent Crystals Composed of Heteroaromatic Cations, p‐Toluenesulfonate Anion, and Aromatic Hydrogen‐Bond Donors
Authors: Uno Koya , Yamakado Ryohei , Okada Shuji , Usman Anwar 
Published: March 2024

AbstractCocrystals with three π‐components, which were a π‐cation, a π‐anion acting as a hydrogen‐bond acceptor, and a π‐molecule acting as a hydrogen‐bond donor, were prepared by the solution‐growth methods. The first and second components were ion pairs of 1‐methylpyridinium or 1‐methylquinolinium p‐toluenesulfonate derivatives, and the third components were dihydric phenol derivatives, like hydroquinone, 1,4‐naphthalenediol, 4,4’‐biphenol, and 1,1’‐bi‐2‐naphthol, or benzoic acid derivatives with hydroxy or amino group at the para position. Among 23 cocrystals found from 35 possible combinations of five ion‐pairs and seven hydrogen‐bond donors, 20 cocrystals were investigated by the X‐ray crystallographic analyses. Some of them also contained solvent molecules. In these cocrystals, hydrogen‐bond sequences composed of p‐toluenesulfonate and the hydrogen‐bond donors were observed, and ionic bonds between the first and second components and hydrogen bonds between the second and third components were found to be responsible for three‐π‐component cocrystals. When the cations were 4‐cyanopyridinium or quinolinium derivatives, the cocrystals showed charge‐transfer absorption bands due to electronic interaction between the cations and the hydrogen‐bond donors. To the mixture of quinolinium p‐toluenesulfonate and 1,1’‐bi‐2‐naphthol forming the three‐π‐component cocrystals, tetrathiafulvalene were added to form four‐π‐component cocrystals with ethanol or water molecules.
Genetic modifiers of cognitive decline in PSEN1 E280A Alzheimer's disease
Authors: Sepulveda‐Falla Diego , Vélez Jorge I. , Acosta‐Baena Natalia , Baena Ana , Moreno Sonia , Krasemann Susanne , Lopera Francisco , Mastronardi Claudio A. , Arcos‐Burgos Mauricio 
Published: March 2024

AbstractINTRODUCTIONRate of cognitive decline (RCD) in Alzheimer's disease (AD) determines the degree of impairment for patients and of burden for caretakers. We studied the association of RCD with genetic variants in AD.METHODSRCD was evaluated in 62 familial AD (FAD) and 53 sporadic AD (SAD) cases, and analyzed by whole‐exome sequencing for association with common exonic functional variants. Findings were validated in post mortem brain tissue.RESULTSOne hundred seventy‐two gene variants in FAD, and 227 gene variants in SAD associated with RCD. In FAD, performance decline of the immediate recall of the Rey‐Osterrieth figure test associated with 122 genetic variants. Olfactory receptor OR51B6 showed the highest number of associated variants. Its expression was detected in temporal cortex neurons.DISCUSSIONImpaired olfactory function has been associated with cognitive impairment in AD. Genetic variants in these or other genes could help to identify risk of faster memory decline in FAD and SAD patients.
Unveiling Phenoxazine's Unique Reversible Two‐Electron Transfer Process and Stable Redox Intermediates for High‐Performance Aqueous Zinc‐ion Batteries
Authors: Ning Jiaoyi , Zhang Xiaopeng , Xie Dongjiu , He Qiang , Hu Jun , Tang Jinjing , Li Rui , Meng Hong , Yao Ke Xin 
Published: March 2024

AbstractThe low specific capacity determined by the limited electron transfer of p‐type cathode materials is the main obstruction to their application towards high‐performance aqueous zinc‐ion batteries (ZIBs). To overcome this challenge, boosting multi‐electron transfer is essential for improving the charge storage capacity. Here, as a typical heteroaromatic p‐type material, we unveil the unique reversible two‐electron redox properties of phenoxazine in the aqueous electrolytes for the first time. The second oxidation process is stabilized in the aqueous electrolytes, a notable contrast to its less reversibility in the non‐aqueous electrolytes. A comprehensive investigation of the redox chemistry mechanism demonstrates remarkably stable redox intermediates, including a stable cation radical PNO⋅+ characterized by effective electron delocalization and a closed‐shell state dication PNO2+. Meanwhile, the heightened aromaticity contributes to superior structural stability during the redox process, distinguishing it from phenazine, which features a non‐equivalent hybridized sp2‐N motif. Leveraging these synergistic advantages, the PNO electrodes deliver a high capacity of 215 mAh g−1 compared to other p‐type materials, and impressive long cycling stability with 100 % capacity retention over 3500 cycles. This work marks a crucial step forward in advanced organic electrodes based on multi‐electron transfer phenoxazine moieties for high‐performance aqueous ZIBs.
Mechanically Adaptive Polymers Constructed from Dynamic Coordination Equilibria
Authors: Zhao Zi‐Han , Chen Shi‐Yi , Zhao Pei‐Chen , Luo Wen‐Lin , Luo Yan‐Long , Zuo Jing‐Lin , Li Cheng‐Hui 
Published: March 2024

AbstractDesigning materials capable of adapting their mechanical properties in response to external stimuli is the key to preventing failure and extending their service life. However, existing mechanically adaptive polymers are hindered by limitations such as inadequate load‐bearing capacity, difficulty in achieving reversible changes, high cost, and a lack of multiple responsiveness. Herein, we address these challenges using dynamic coordination bonds. A new type of mechanically adaptive material with both rate‐ and temperature‐responsiveness was developed. Owing to the stimuli‐responsiveness of the coordination equilibria, the prepared polymers, PBMBD‐Fe and PBMBD‐Co, exhibit mechanically adaptive properties, including temperature‐sensitive strength modulation and rate‐dependent impact hardening. Benefitting from the dynamic nature of the coordination bonds, the polymers exhibited impressive energy dissipation, damping capacity (loss factors of 1.15 and 2.09 at 1.0 Hz), self‐healing, and 3D printing abilities, offering durable and customizable impact resistance and protective performance. The development of impact‐resistant materials with comprehensive properties has potential applications in the sustainable and intelligent protection fields.
Achieving High Fill Factor in Organic Photovoltaic Cells by Tuning Molecular Electrostatic Potential Fluctuation
Authors: Wang Guanlin , Wang Jingwen , Cui Yong , Chen Zhihao , Wang Wenxuan , Yu Yue , Zhang Tao , Ma Lijiao , Xiao Yang , Qiao Jiawei , Xu Ye , Hao Xiao‐Tao , Hou Jianhui 
Published: March 2024

AbstractIn the field of organic photovoltaics (OPVs), significant progress has been made in tailoring molecular structures to enhance the open‐circuit voltage and the short‐circuit current density. However, there remains a crucial gap in the development of coordinated material design strategies focused on improving the fill factor (FF). Here, we introduce a molecular design strategy that incorporates electrostatic potential fluctuation to design organic photovoltaic materials. By reducing the fluctuation amplitude of IT‐4F, we synthesized a new acceptor named ITOC6‐4F. When using PBQx‐TF as a donor, the ITOC6‐4F‐based cell shows a markedly low recombination rate constant of 0.66×10−14 cm3 s−1 and demonstrates an outstanding FF of 0.816, both of which are new records for binary OPV cells. Also, we find that a small fluctuation amplitude could decrease the energetic disorder of OPV cells, reducing energy loss. Finally, the ITOC6‐4F‐based cell creates the highest efficiency of 16.0 % among medium‐gap OPV cells. Our work holds a vital implication for guiding the design of high‐performance OPV materials.
Imidazolium‐based ionic thermoplastic polyurethane with low surface energy and antibacterial activities
Authors: Sun Jie , Zhao Yue , Xu Zhiqian , Ge Zhen 
Published: March 2024

AbstractA series of novel thermoplastic polyurethane elastomers with both low surface energy and antibacterial activity were synthesized in this paper. Firstly, four imidazole salt diols with different alkyl chain lengths at the N‐position of imidazolium cation ([CnIm+][Cl−]) were prepared. Then, imidazolium‐based ionic thermoplastic polyurethane elastomers (Si‐ITPUs) were formulated by incorporating polydimethylsiloxane and polytetramethylene glycol as a mixed soft segment, 1,4‐butanediol and [CnIm+][Cl−] as a chain extender, and 4,4′‐dicyclohexylmethane diisocyanate. The structure, thermal stability, mechanical properties, physical crosslinking density, and the anti‐graffiti properties of Si‐ITPUs were evaluated. The surface energy and water absorption were evaluated through static contact angle and water resistance tests, respectively. Furthermore, the antibacterial activities against both Staphylococcus.aureus and Escherichia coli were characterized by the plate colony counting method. The results demonstrated that Si‐ITPUs possessed surface energy of approximately 23 mN/m, which conferred excellent anti‐graffiti and self‐cleaning performance. Furthermore, the increase of the alkyl chain length of substitutions resulted in a decrease in the tensile strength but an increase in the elongation at break. Si‐ITPU‐C4 exhibited optimized antibacterial activities with an antibacterial rate of more than 99.9% against both S. aureus and E. coli. This novel polyurethane is anticipated to find applications in the medical device industry and food processing sector.
A search for factors associated with reduced carbohydrate intake and NTD risk in two population‐based studies
Authors: Shaw Gary M. , Yang Wei , Weber Kari A. , Olshan Andrew F. , Desrosiers Tania A. ,   The National Birth Defects Prevention Study
Published: March 2024

AbstractBackgroundTwo population‐based case–control studies have reported an increased risk of neural tube defect (NTD)‐affected pregnancies among women with low carbohydrate diet in the periconceptional period. Given that only two studies have investigated this association, it is unclear to what degree the findings could be impacted by residual confounding. Here, we further interrogated both studies that observed this association with the objective to identify factors from a much larger number of factors that might explain the association.MethodsBy employing a machine learning algorithm (random forest), we investigated a baseline set of over 200 variables. These analyses produced the top 10 variables in each data set for cases and controls that predicted periconceptional low carbohydrate intake.ResultsExamining those prediction variables with logistic regression modeling, we did not observe any particular variable that substantially contributed to the NTD‐low carbohydrate association in either data set.ConclusionsIf there are underlying factors that explain the association, our findings suggest that none of the 200+ variables we examined were sufficiently correlated with what that true explanatory exposure may be. Alternatively, our findings may suggest that there are other unidentified factor(s) at play, or the association observed in two independent data sets is directly related to low carbohydrate intake.
ASIA: An automated stress‐inducible adaptor for enhanced stress protein expression in engineered Escherichia coli
Authors: Hsiang Chuan‐Chieh , Ng I‐Son 
Published: March 2024

AbstractOrthogonal T7 RNA polymerase (T7RNAP) and T7 promoter is a potent technique for protein expression in broad cells, but the energy requirements associated with this method impede the growth, leading to cell lysis when dealing with toxic and stress proteins. A Lemo21(DE3) strain denoted as L21 offers a solution by fine‐tuning T7RNAP levels under rhamnose to induce T7 lysozyme (LysY) and enhance the protein production, but it requires optimization of inducer concentration, cultural temperature, and condition, even the types of carbon sources. Herein, we construct an automated stress‐inducible adaptor (ASIA) employing different stress‐inducible promoters from Escherichia coli. The ASIA system is designed to automatically regulate LysY expression in response to stress signals, thereby suppressing T7RNAP and amplifying the overexpression of stress protein cutinase ICCM. This approach fine‐tunes T7RNAP levels and outperforms L21 in various temperatures and carbon source conditions. The ASIAhtp strain maintains ICCM yield at 91.6 mg/g‐DCW even in the limiting carbon source at 1 g/L, which is 12‐fold higher in protein productivity compared to using L21. ASIA as a versatile and robust tool for enhancing overexpression of stress proteins in E. coli is expected to address more difficult proteins in the future.
Histologic wound healing in studies using different ridge preservation protocols: A review
Authors: Mealey Brian L. , Keeling Francis , Palaiologou A. Archontia 
Published: March 2024

AbstractBackgroundAlveolar ridge preservation (ARP) procedures are designed to lessen dimensional changes in the alveolar ridge after tooth extraction. Wound healing after ridge preservation involves the formation of new vital bone in the former socket, and this vital bone is important in the osseointegration of dental implants.MethodsA series of ARP studies have been performed to help clinicians better understand the wound‐healing events that occur following tooth extraction and ridge preservation. Different protocols have been examined using various materials and periods of healing time prior to implant placement. The primary aim of these studies was to ascertain the relative percentage of vital bone formation, residual graft material, and connective tissue (CT)/other at the healing site using histomorphometric examination of bone core biopsies obtained during osteotomy preparation.ResultsFor allografts, the use of demineralized bone alone or in combination with mineralized is associated with more vital bone formation than the use of mineralized allograft alone. For mineralized allografts, the use of cortical versus cancellous bone has only minimal impact on new bone formation. Xenografts from bovine and porcine sources appear to have similar vital bone formation. Longer healing times prior to implant placement are associated with increased vital bone formation and decreased residual graft material. The most stable component in most studies is the percentage of CT/other.ConclusionsThe percentage of vital bone and residual graft at ARP sites is dependent on the materials used and the length of healing time prior to obtaining core biopsies.Key PointsWhat factors may affect the amount of new bone at the ARP site?

At a time point about 4 months after ARP, the type of graft material used for ARP plays a large role in new bone formation.
Studies focus on means and standard deviations, but patients often do not “follow the mean.” Even if a single ARP protocol is used for all patients, there is great interindividual variability in new bone formation, and there is often variability between sites within a single patient.
How long after ARP with an allograft should I wait to place an implant?

Longer healing times such as 4‐5 months generally provide higher amounts of vital bone formation than shorter healing times like 2‐3 months.
Differences in vital bone formation between ARP protocols tend to decrease with longer healing time.
FDBA that contains demineralized bone, either alone or combined with mineralized FDBA, often provides higher amounts of new bone formation than 100% mineralized allograft, especially at shorter healing periods.
Even a year after ARP with an allograft, residual graft material is often still present at the ARP site.
Ultrasound‐guided deployment of ProGlide™ device in transfemoral transcatheter aortic valve implantation and risk reduction of vascular complications: A propensity‐matched cohort study
Authors: Ross Daniel S. , Nogic Jason , Cong Hey , Nuzzi Vincenzo , Thanikachalam Prakash , Veenuraju Shree , Gruner‐Hegge Nicolai , Anwar Majid , O'Sullivan Michael , Costopoulos Charis , Davies Willaim R , Costanzo Pierluigi 
Published: March 2024

AbstractBackgroundProGlide is a percutaneous suture‐mediated closure device used in arterial and venous closure following percutaneous intervention. Risk of vascular complications from use, particularly related to failure in hemostasis, or acute vessel closure, remains significant and often related to improper suture deployment. We describe a technique of ultrasound‐guided ProGlide deployment in transfemoral transcatheter aortic valve implantation (TF‐TAVI).AimsThe aim of this study is to assess vascular outcomes for ultrasound‐guided deployment of ProGlide vascular closure devices in patients undergoing TF‐TAVI.MethodsWe collected relevant clinical data of patients undergoing TAVI in a large volume centre. Primary outcome: main access Valve Academic Research Consortium 3 (VARC‐3) major vascular complication. Secondary outcome: any major/minor VARC‐3 vascular complication, its type (bleed or ischemia), and treatment required (medical, percutaneous, or surgical). We performed inverse weighting propensity score analysis to compare the population undergoing ultrasound‐guided versus conventional ProGlide deployment for main TAVI access. Ultrasound technique for ProGlide insertion was performed as described below.ResultsFive hundred and seventeen patients undergoing TF‐TAVI were included.Primary outcome: In 126 (ultrasound‐guided) and 391 (conventional ProGlide insertion), 0% versus 1.8% (p < 0.001) had a major VARC‐3 vascular complication, respectively.Secondary outcome: 0.8% (one minor VARC‐3 bleed) vs 4.1% (13 bleeds and three occlusions) had any VARC‐3 vascular complication (major and minor) (p < 0.001). Surgical treatment of vascular complication was required in 0.8% versus 1.3% (p = NS).ConclusionsUltrasound‐guided deployment of ProGlide for vascular closure reduced the risk of major vascular complications in a large population undergoing TAVI.
Rapidly growing distal choroidal artery aneurysm re‐rupture following revascularization for hemorrhagic Moyamoya disease: A case report
Authors: Yoon Jeong Taek , Lee Kyung Mi , Ryu Jiwook , Park Ju In 
Published: March 2024

Key Clinical MessageIntracranial hemorrhage is the leading cause of neurological deficits and poor prognosis in adult patients with Moyamoya disease (MMD). Intracranial hemorrhage is occasionally accompanied by MMD‐associated aneurysm and requires additional treatment. To date, direct or indirect bypass surgery or endovascular treatment, such as coil embolization, has been adopted and has achieved successful outcomes. The rapid growth of MMD‐associated aneurysms and rebleeding after direct bypass surgery via superficial temporal artery‐middle cerebral artery (STA‐MCA) anastomosis has rarely been reported. We report a case of a rapidly growing fragile arterial pseudoaneurysm in a patient with MMD. A 45‐year‐old female was admitted with a headache and decreased mental status. Radiological evaluation, including distal subtraction angiography, revealed intraventricular hemorrhage with a left posterior choroidal artery pseudoaneurysm. Within 4 days after revascularization surgery via STA‐MCA direct bypass, the size of the pseudoaneurysm rapidly increased and rebleeding occurred, requiring coil embolization. After endovascular therapy and a second STA‐MCA bypass surgery, the patient recovered well and was discharged 8 days later. Follow‐up radiological imaging revealed an obliterated pseudoaneurysm without rebleeding or complications. In this case, the rapid growth of an MMD‐associated pseudoaneurysm was observed after revascularization surgery because of temporary hemodynamic instability. This report raises questions regarding the causes and management of unstable postbypass hemodynamics.
Pigmented purpuric dermatosis (Majocchi type) in a patient with vitiligo
Authors: Chaisrimaneepan Nattanicha , Manupeerapun Hataitip , Khoruamklang Thunyaporn 
Published: March 2024

Key Clinical MessagePigmented purpuric dermatosis is diagnosed clinically and does not require skin biopsy. However, in cases where rashes mimic cutaneous vasculitis, skin biopsies should be done to confirm the diagnosis, especially in patients who have underlying autoimmune disease.
Catalyst‐Green Solvent System for Highly Efficient Production of Carboxylic Acids from Light Oxygenates, CO2 and H2
Authors: Wang Yanyan , Zhang Yanru , Wang Ying , Zhang Longbo , He Jun , Yu Chenglong , Li Yang , Zhang Pei , Ma Jun , Sun Xiaofu , Kang Xinchen , Zhen Yuan , Qian Qingli , Han Buxing 
Published: March 2024

AbstractCatalytic hydrogenation of carbon dioxide (CO2) for the preparation of higher carboxylic acids is attractive and promising. Herein, we demonstrate a general strategy for producing higher carboxylic acids via reaction of CO2 and H2 with light (C2~C4) oxygenates such as ketones, alcohols, polyols, ethers and epoxides. In a green solvent consisting of ionic liquid (1‐ethyl‐3‐methylimidazolium iodide) and water, the reaction can be efficiently accelerated by RhI3 catalyst and I2 promoter at 170 °C. Very high or remarkable yields of higher carboxylic acids were synthesized via C−C bond formation between the intermediates generated from the oxygenates and CO2. Detailed study indicated that the catalyst and the solvent had excellent synergistic effect for promoting the reaction. The strategy can effectively convert the bulk and inexpensive feedstocks to value‐added carboxylic acids, and therefore is promising for commercial application.
The Construction of Helical Carbon‐Based Skeletons for Enhanced Electrocatalytic Performance
Authors: Yao Huijuan , Zhang Hang , Zheng Haoquan 
Published: March 2024

AbstractAs an excellent class of electrode materials, carbon‐based materials have garnered sustained attention. Constructing carbon‐based skeleton with unique structure has become a vital research area in the fields of electrocatalysis. Recently, surface curvature has been extensive discussed as a compelling factor in electronic modulation for electrocatalyst design. Benefitting from its distinctive regulation, the intrinsic activity and service stability of catalysts during electrocatalytic process can be significantly improved. Therefore, a helical structure that adeptly integrates well‐regulated, highly ordered surface curvatures is considered to be of great research value for the synthesis of carbon‐based skeleton. In this Concept article, we systematically summarize the up‐to‐date reports on the synthetic methods of carbon‐based skeletons with helical structures and present major challenges in this field. We also emphasize that the helical carbon‐based skeleton could be combined with transition metals for cooperative coupling, potentially leading to the further development of high‐efficiency electrocatalysts.
Progress, Prospects and Challenges of MXene Integrated Optoelectronics Devices
Authors: Hossaın Md. Tanvir , Repon Md. Reazuddin , Shahid Md. Abdus , Ali Ayub , Islam Tarikul 
Published: March 2024

AbstractRecently, the emerging 2D materials MXene have gained a surge of attention to the production of optoelectronics devices such as solar cells, plasmonic, phototransistors, photodetectors, light‐emitting diodes, photothermal therapy, and so on. Its outstanding optical and electrical characteristics, unique structure, and large specific surface area make it suitable for future use in modern optoelectronics including ultrafast lasers, light emitters, modulators, and plasmonic generators. There is a lack of critical analysis on the prospects, challenges, overview of synthesis methods, mechanisms, and future research directions of MXene despite having some reviews have been published on the applications of MXene. Therefore, this study critically analyzed the existing challenges of MXene, such as poor stability in an oxygen environment, inadequate mechanical properties, ease of stacking, temperature barrier, and so on. In addition, the fundamentals, preparation techniques, properties, and applications of MXene have been summarized. The mechanism, limitations, and benefits of different preparation methods have been mentioned. A comprehensive analysis and guidelines have been provided to improve the existing synthesis methods. The ways to overcome these challenges, prospects, and future markets of the MXene‐based optoelectronic devices have been described.