bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prepregnancy body mass index and other risk factors for early-onset and late-onset haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome: a population-based retrospective cohort study in British Columbia, Canada
Authors: Wang Li Qing , Bone Jeffrey N , Muraca Giulia M , Razaz Neda , Joseph K S , Lisonkova Sarka 
Published: March 2024

BackgroundObesity increases risk of pre-eclampsia, but the association with haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome is understudied.ObjectiveTo examine the association between prepregnancy body mass index (BMI) and HELLP syndrome, including early-onset versus late-onset disease.Study designA retrospective cohort study using population-based data.SettingBritish Columbia, Canada, 2008/2009–2019/2020.PopulationAll pregnancies resulting in live births or stillbirths at ≥20 weeks’ gestation.MethodsBMI categories (kg/m2) included underweight (<18.5), normal (18.5–24.9), overweight (25.0–29.9) and obese (≥30.0). Rates of early-onset and late-onset HELLP syndrome (<34 vs ≥34 weeks, respectively) were calculated per 1000 ongoing pregnancies at 20 and 34 weeks’ gestation, respectively. Cox regression was used to assess the associations between risk factors (eg, BMI, maternal age and parity) and early-onset versus late-onset HELLP syndrome.Main outcome measuresEarly-onset and late-onset HELLP syndrome.ResultsThe rates of HELLP syndrome per 1000 women were 2.8 overall (1116 cases among 391 941 women), and 1.9, 2.5, 3.2 and 4.0 in underweight, normal BMI, overweight and obese categories, respectively. Overall, gestational age-specific rates of HELLP syndrome increased with prepregnancy BMI. Obesity (compared with normal BMI) was more strongly associated with early-onset HELLP syndrome (adjusted HR (AHR) 2.24 (95% CI 1.65 to 3.04) than with late-onset HELLP syndrome (AHR 1.48, 95% CI 1.23 to 1.80) (p value for interaction 0.025). Chronic hypertension, multiple gestation, bleeding (<20 weeks’ gestation and antepartum) also showed differing AHRs between early-onset versus late-onset HELLP syndrome.ConclusionsPrepregnancy BMI is positively associated with HELLP syndrome and the association is stronger with early-onset HELLP syndrome. Associations with early-onset and late-onset HELLP syndrome differed for some risk factors, suggesting possible differences in aetiological mechanisms.
Comparing blastocyst euploid rates between the progestin-primed and gonadotrophin-releasing hormone antagonist protocols in aneuploidy genetic testing: a randomised trial protocol
Authors: Li He , Yu Min , Zhang Wenbi , Chen Junling , Chen Hua , Lu Xiang , Li Lu , Ng Ernest H Y , Sun Xiaoxi 
Published: March 2024

IntroductionProgestin can inhibit the pituitary luteinising hormone (LH) surge during ovarian stimulation for in vitro fertilisation (IVF) and studies show progestin-primed ovarian stimulation (PPOS) is effective in blocking the LH surge in IVF. More and more centres are using PPOS because this regimen appears simpler and cheaper. This study aims to compare the euploidy rate of blastocysts following the PPOS protocol and the gonadotropin-releasing hormone antagonist protocol in women undergoing preimplantation genetic testing for aneuploidy (PGT-A).Methods/analysisThis is a randomised trial. A total of 400 women undergoing PGT-A will be enrolled and randomised according to a computer-generated randomisation list to either (1) the antagonist group: an antagonist given once daily from day 6 of ovarian stimulation till the day of the ovulation trigger; or (2) the PPOS group: dydrogesterone from the first day of ovarian stimulation till the day of ovulation trigger. The primary outcome is the euploidy rate of blastocysts.Ethics/disseminationAn ethical approval was granted from the ethics committee of assisted reproductive medicine in Shanghai JiAi Genetics and IVF institute (JIAIE2020-03). A written informed consent will be obtained from each woman before any study procedure is performed, according to good clinical practice. The results of this randomised trial will be disseminated in a peer-reviewed journal.Trial registration numberNCT04414748.
Non-linear relationship between pulse pressure and the risk of pre-diabetes: a secondary retrospective Chinese cohort study
Authors: Cao Changchun , Han Yong , Hu Haofei , He Yongcheng , Luo Jiao 
Published: March 2024

ObjectivePrevious research has shown that pulse pressure (PP) has a significant role in the start and development of type 2 diabetes mellitus. However, there is little proof that PP and pre-diabetes mellitus (Pre-DM) are related. Our study aimed to investigate the relationship between PP and incident pre-DM in a substantial cohort of Chinese participants.DesignThe ‘DATADRYAD’ database (www.Datadryad.org) was used to retrieve the data for this secondary retrospective cohort analysis.ParticipantsData from 182 672 Chinese individuals who participated in the medical examination programme were recorded in this retrospective cohort study between 2010 and 2016 across 32 sites and 11 cities in China.SettingPP assessed at baseline and incident pre-DM during follow-up were the target-independent and dependent variables. The association between PP and pre-DM was investigated using Cox proportional hazards regression.Primary outcome measuresThe outcome was incident pre-DM. Impaired fasting glucose levels (fasting blood glucose between 5.6 and 6.9 mmol/L) were used to define pre-DM.ResultsAfter controlling for confounding variables, PP was positively correlated with incident pre-DM among Chinese adults (HR 1.009, 95% CI 1.007 to 1.010). Additionally, at a PP inflection point of 29 mm Hg, a non-linear connection between the PP and incident pre-DM was discovered. Increased PP was an independent risk factor for developing pre-DM when PP was greater than 29 mm Hg. However, their association was not significant when PP was less than 29 mm Hg. According to subgroup analyses, females, never-smokers and non-obesity correlated more significantly with PP and pre-DM.ConclusionWe discovered that higher PP independently correlated with pre-DM risk in this study of Chinese participants. The connection between PP and incident pre-DM was also non-linear. High PP levels were related to a higher risk of pre-DM when PP was above 29 mm Hg.Article focusOur study investigated the relationship between PP and incident pre-DM in a secondary retrospective cohort of Chinese participants.
Return of participant-level clinical trial results to participants: pilot of a simplified centralised approach
Authors: Hoffman Eric , Gaglianone Suzanne , Ketema Rahel , Tu Wangshu , Peay Holly , Clemens Paula , Dang Utkarsh , Conklin Laurie 
Published: March 2024

ObjectivesPublic access databases such as clinicaltrials.gov achieve dissemination of clinical trial design and aggregated study results. However, return of participant-level data is rarely done. A key barrier includes the proprietary ownership of data by the sponsor. Additionally, investigators may not have access to centralised data, and per International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) Good Clinical Practice, must maintain the confidentiality of participants. This study piloted an approach to return both individual and aggregate clinical trial data to parents of children participating in a series of open-label clinical trials.Setting and designA small biotech company obtained central ethics approval (centralised institutional review board [IRB], non-exempt). The study was advertised via parent advocacy groups. Parents of trial participants were offered the option to contact an employee (coordinator) within the company, requesting return of their child’s study results. Ethics approval covered participation in six countries. The study focused on the sequential clinical trials of vamorolone VBP15-002 (NCT02760264) and VBP15-003 (NCT02760277) (post-results).InterventionsContact initiated by the parent enabled the coordinator to obtain informed consent (and separate General Data Protection Regulations consent), with phone translation when needed. Using date of birth and study site location provided by the parent, the data manager reported the participant number to the coordinator. The coordinator retrieved and compiled data, along with an aggregate summary, which was mailed via a password protected and encrypted memory device to the parent. Prereturn and postreturn surveys were sent to consented parents (n=19; 40% of 48 total trial participants) and investigators.ResultsPrereturn surveys indicated a request for as much data as offered, in all formats offered. Postreturn survey showed high satisfaction with the process and data returned. Survey of the physician site investigators (n=10; 100% participation of investigators) voiced general satisfaction with the process, with some reservations.ConclusionsThis pilot study demonstrates an innovative, cost-effective, centralised and labour conservative approach to return of participant-level and aggregate data to participants in studies.
Defining the hidden burden of disease in rural communities in Bangladesh, Cambodia and Thailand: a cross-sectional household health survey protocol
Authors: Zhang Meiwen , Htun Nan Shwe Nwe , Islam Shayla , Sen Aninda , Islam Akramul , Neogi Amit Kumer , Tripura Rupam , Dysoley Lek , Perrone Carlo , Chew Rusheng , Batty Elizabeth M , Thongpiam Watcharintorn , Wongsantichon Jantana , Menggred Chonticha , Zaman Sazid Ibna , Waithira Naomi , Blacksell Stuart , Liverani Marco , Lee Sue , Maude Richard James , Day Nicholas P J , Lubell Yoel , Peto Thomas Julian 
Published: March 2024

IntroductionIn low-income and middle-income countries in Southeast Asia, the burden of diseases among rural population remains poorly understood, posing a challenge for effective healthcare prioritisation and resource allocation. Addressing this knowledge gap, the South and Southeast Asia Community-based Trials Network (SEACTN) will undertake a survey that aims to determine the prevalence of a wide range of non-communicable and communicable diseases, as one of the key initiatives of its first project—the Rural Febrile Illness project (RFI). This survey, alongside other RFI studies that explore fever aetiology, leading causes of mortality, and establishing village and health facility maps and profiles, will provide an updated epidemiological background of the rural areas where the network is operational.Methods and analysisDuring 2022–2023, a cross-sectional household survey will be conducted across three SEACTN sites in Bangladesh, Cambodia and Thailand. Using a two-stage cluster-sampling approach, we will employ a probability-proportional-to-size sample method for village, and a simple random sample for household, selection, enrolling all members from the selected households. Approximately 1500 participants will be enrolled per country. Participants will undergo questionnaire interview, physical examination and haemoglobin point-of-care testing. Blood samples will be collected and sent to central laboratories to test for chronic and acute infections, and biomarkers associated with cardiovascular disease, and diabetes. Prevalences will be presented as an overall estimate by country, and stratified and compared across sites and participants’ sociodemographic characteristics. Associations between disease status, risk factors and other characteristics will be explored.Ethics and disseminationThis study protocol has been approved by the Oxford Tropical Research Ethics Committee, National Research Ethics Committee of Bangladesh Medical Research Council, the Cambodian National Ethics Committee for Health Research, the Chiang Rai Provincial Public Health Research Ethical Committee. The results will be disseminated via the local health authorities and partners, peer-reviewed journals and conference presentations.Trial registration numberNCT05389540.
Association of the triglyceride-glucose index with severity of coronary stenosis and in-hospital mortality in patients with acute ST elevation myocardial infarction after percutaneous coronary intervention: a multicentre retrospective analysis cohort study
Authors: Lu Xin , Lin Xin , Cai Yingying , Zhang Xiaoxiao , Meng Haoyu , Chen Weiwei , Yu Peng , Chen Xiaohu 
Published: March 2024

ObjectivesTo explore the impact of the triglyceride-glucose (TyG) index on the severity of coronary stenosis and the risk of in-hospital mortality in patients with acute ST segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI).DesignA multicentre retrospective cohort study.SettingPatients with STEMI undergoing PCI from three centres in China from 2015 to 2019.ParticipantsA total of 1491 individuals presenting with STEMI were enrolled.Primary outcome measureThe degree of coronary stenosis was quantified by the Gensini score (GS). The association between the TyG index and the severity of coronary stenosis was explored by using a logistic regression analysis. Cox proportional hazards regression analyses were used to investigate the associations between the variables and in-hospital mortality.ResultsWe found a significant correlation between the TyG index and the degree of coronary stenosis in the present study. The TyG index was an independent risk factor for the severity of coronary stenosis (OR 2.003, p<0.001). Using the lowest tertile of the TyG (T1) group as a reference, the adjusted ORs for the T2 group and the T3 group and a high GS were 1.732 (p<0.001), 1.968 (p<0.001), respectively, and all p for trend <0.001. For predicting a high GS, the TyG index’s area under the curve was 0.668 (95% CI 0.635 to 0.700, p<0.001). Additionally, the TyG index was further demonstrated to be an independent predictor of in-hospital mortality in patients with STEMI (HR 1.525, p<0.001).ConclusionsThe TyG index was associated with the severity of coronary stenosis and all-cause in-hospital mortality in patients with STEMI, which may help physicians precisely risk-stratify patients and implement individualised treatment.
Prostate Cancer Survivorship Essentials for men with prostate cancer on androgen deprivation therapy: protocol for a randomised controlled trial of a tele-based nurse-led survivorship care intervention (PCEssentials Hormone Therapy Study)
Authors: Green Anna , Newton Robert U , Smith David P , Tuffaha Haitham , Galvão Daniel A , Heathcote Peter , Patel Manish I , Christie David , Egger Sam , Sara Sally AM , Heneka Nicole , Chambers Suzanne K , Dunn Jeff 
Published: March 2024

IntroductionAndrogen deprivation therapy (ADT) is commonly used to treat men with locally advanced or metastatic prostate cancer. Men receiving ADT experience numerous side effects and frequently report unmet supportive care needs. An essential part of quality cancer care is survivorship care. To date, an optimal effective approach to survivorship care for men with prostate cancer on ADT has not been described. This protocol describes a randomised trial of tele-based nurse-led survivorship that addresses this knowledge gap: (1) determine the effectiveness of a nurse-led survivorship care intervention (PCEssentials), relative to usual care, for improving health-related quality of life (HR-QoL) in men with prostate cancer undergoing ADT and (2) evaluate PCEssentials implementation strategies and outcomes, including cost-effectiveness, compared with usual care.Methods and analysisThis is an effectiveness-implementation hybrid (type 1) trial with participants randomised to one of two arms: (1) minimally enhanced usual care and (2) nurse-led prostate cancer survivorship essentials (PCEssentials) delivered over four tele-based sessions, with a booster session 5 months after session 1. Eligible participants are Australian men with prostate cancer commencing ADT and expected to be on ADT for a minimum of 12 months. Participants are followed up at 3, 6 and 12 months postrecruitment. Primary outcomes are HR-QoL and self-efficacy. Secondary outcomes are psychological distress, insomnia, fatigue and physical activity. A concurrent process evaluation with participants and study stakeholders will be undertaken to determine effectiveness of delivery of PCEssentials.Ethics and disseminationEthics approval was obtained from the Metro South Health HREC (HREC/2021/QMS/79429). All participants are required to provide written informed consent. Outcomes of this trial will be published in peer-reviewed journals. The findings will be presented at conferences and meetings, local hospital departments, participating organisations/clinical services, and university seminars, and communicated at community and consumer-led forums.Trial registration numberACTRN12622000025730.
Development and validation of an assessment tool for adult simulated ultrasound-guided fascia iliaca block: a prospective monocentric study
Authors: Guyader Frederic-Pierre , Violeau Mathieu , Guenezan Jérémy , Guechi Youcef , Breque Cyril , Betoulle-Masset Pauline , Faure Jean-Pierre , Oriot Denis , Ghazali Daniel Aiham 
Published: March 2024

BackgroundFascia iliaca block (FIB) is an effective technique for analgesia. While FIB using ultrasound is preferred, there is no current standardised training technique or assessment scale. We aimed to create a valid and reliable tool to assess ultrasound-guided FIB.MethodThis prospective observational study was conducted in the ABS-Lab simulation centre, University of Poitiers, France between 26–29 October and 14–17 December 2021. Psychometric testing included validity analysis and reliability between two independent observers. Content validity was established using the Delphi method. Three rounds of feedback were required to reach consensus. To validate the scale, 26 residents and 24 emergency physicians performed a simulated FIB on SIMLIFE, a simulator using a pulsated, revascularised and reventilated cadaver. Validity was tested using Cronbach’s α coefficient for internal consistency. Comparative and Spearman’s correlation analysis was performed to determine whether the scale discriminated by learner experience with FIB and professional status. Reliability was analysed using the intraclass correlation (ICC) coefficient and a correlation score using linear regression (R2).ResultsThe final 30-item scale had 8 parts scoring 30 points: patient positioning, preparation of aseptic and tools, anatomical and ultrasound identification, local anaesthesia, needle insertion, injection, final ultrasound control and signs of local anaesthetic systemic toxicity. Psychometric characteristics were as follows: Cronbach’s α was 0.83, ICC was 0.96 and R2was 0.91. The performance score was significantly higher for learners with FIB experience compared with those without experience: 26.5 (22.0; 29.0) vs 22.5 (16.0; 26.0), respectively (p=0.02). There was a significant difference between emergency residents’ and emergency physicians’ scores: 20.5 (17.0; 25.0) vs 27.0 (26.0; 29.0), respectively (p=0.0001). The performance was correlated with clinical experience (Rho=0.858, p<0.0001).ConclusionThis assessment scale was found to be valid, reliable and able to identify different levels of experience with ultrasound-guided FIB.
Phase-space analysis of torsion-coupled dilatonic ghost condensate
Authors: Gonzalez-Espinoza Manuel , Otalora Giovanni , Leyva Yoelsy , Saavedra Joel 
Published: March 2024

AbstractWe studied the cosmological dynamics of a dilatonic ghost condensate field as a source of dark energy, which is non-minimally coupled to gravity through torsion. We performed a detailed phase-space analysis by finding all the critical points and their stability conditions. Also, we compared our results with the latest H(z) and Supernovae Ia observational data. In particular, we found the conditions for the existence of scaling regimes during the dark matter era. Furthermore, we obtained the conditions for a successful exit from the scaling regime, such that, at late times, the universe tends towards an attractor point describing the dark energy-dominated era. These intriguing features can allow us to alleviate the energy scale problem of dark energy since, during a scaling regime, the field energy density is not necessarily negligible at early times.
An Intrusion Detection System against RPL-based Routing Attacks for IoT Networks
Authors: Hebbaka Shivanajappa Manjula , Maidanahalli Seetharamaiah Roopa , Viswaraju Sai Bharath , Jakkanahally Siddegowda Arunalatha , Kuppanna Rajuk Venugopal 
Published: March 2024

<span lang="EN-US">The significant improvement in the Internet, Internet of Things (IoT), communication, and cloud computing have created considerable challenges in providing security for data and devices. In IoT networks, “Routing Protocol for Low power and Lossy networks”- (RPL) is a communication protocol that enables devices to exchange information and communicate with limited resources like low processing capabilities, less memory and energy. Through the Internet, unauthorised users can access RPL-based IoT networks, making these networks susceptible to routing attacks. Therefore, it is crucial to design Intrusion Detection System-(IDS) to address attacks from IoT communication devices. In this paper, we have proposed GCNConv, a Graph Neural Network (GNN) method that allows capturing the edge and node features of a graph to identify routing attacks. The proposed system has experimented on the RADAR dataset and experimental findings proved that, our approach performs well compared to state-of-the-art method with reference to precision, F1-score, accuracy and recall.</span>
Human Rights Standards as a Bar to Extradition from the European Union to the United Kingdom
Authors: van Zyl Smit Dirk 
Published: March 2024

Abstract
Since 1 January 2021, the Trade and Cooperation Agreement between the United Kingdom and the European Union has regulated extradition to and from the United Kingdom and Member States of the European Union. A recent judgment of a German court denying extradition of a suspect to the United Kingdom illustrates the subtle differences between the terms and operation of the Trade and Cooperation Agreement Warrant and those of the European Arrest Warrant that had applied previously.
This paper notes the absence of mutual trust as an underlying principle in the Trade and Cooperation Agreement, and the failure of the British authorities to grasp and respond to the changed criteria. At the same time, it highlights the implications of a judgment that finds that the treatment of prisoners in British prisons might be so inhuman and degrading that persons should not be extradited to face imprisonment in the United Kingdom.
The Antiquarian Alessandro Totti da Brescia: his Annotated Copy of the Epigrammata Antiquae Urbis (Rome, 1521) and his Autograph Papers in Vat. lat. 5237
Authors: González Germain Gerard 
Published: March 2024

Abstract
In 2022 the Johns Hopkins University purchased an annotated copy of the Epigrammata Antiquae Urbis (Rome, 1521), the earliest published collection of inscriptions from Rome. A paleographical comparison shows that the annotator was the Servite friar Alessandro Totti (1498–1570), a little-studied Brescian antiquarian. The present study confirms him as the source of numerous papers within Vat. lat. 5237 (a composite epigraphic manuscript assembled by Aldo Manuzio the Younger), and sheds light on his exchange of antiquarian information with Ottavio Pantagato, Paolo Manuzio, and his son Aldo Manuzio. The analysis of Totti’s annotations in the Epigrammata, written in the 1550s, reveals not only his detailed study of Rome’s inscriptions, but also his interest in two of the most heated antiquarian debates at the time: Roman chronology as attested by the discovery of the Fasti Capitolini, and the identification of the 35 Roman tribes.