bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomized trial of a wearable UV dosimeter for skin cancer prevention
Authors: Dumont Emmanuel L. P. , Kaplan Peter D. , Do Catherine , Banerjee Shayak , Barrer Melissa , Ezzedine Khaled , Zippin Jonathan H. , Varghese George I. 
Published: March 2024

BackgroundNon-melanoma skin cancer (NMSC) is the most prevalent cancer in the United States. Despite guidelines on ultraviolet (UV) avoidance, it remains difficult for people to assess their exposure, as UV is invisible and the onset of UV-induced symptoms is delayed.MethodsIn a prospective randomized trial, 97 elderly patients with a history of actinic keratoses (AK) were followed over 6 months. Fifty patients received UV counseling from a dermatologist and a wearable UV dosimeter that provided real-time and cumulative UV exposure. Forty-seven patients received only UV counseling from a dermatologist.ResultsOver 75% of participants recorded UV exposure at least once a week during the summer. After 6 months of intervention, when comparing the device group to the control group, we observed a non-significant 20% lower ratio of incidence rates of AKs (95% CI = [−41, 55%], p-value = 0.44) and a significant 95% lower ratio of incidence rates of NMSCs (95% CI = [33, 99.6%], p-value = 0.024). Surveys demonstrated that the control group’s score in self-perceived ability to participate in social activities significantly increased by 1.2 (p-value = 0.04), while in the device group, this score non-significantly decreased by 0.9 (p-value = 0.1). We did not observe changes, or between-group differences, in anxiety and depression surveys.ConclusionThis pilot clinical trial has a short duration and a small sample size. However, device adherence and quality of life questionnaires suggest a smartphone-connected wearable UV dosimeter is well accepted by an elderly population. This trial also indicates that a wearable UV dosimeter may be an effective behavioral change tool to reduce NMSC incidence in an elderly population with a prior history of AKs.Clinical trial registration: clinicaltrials.gov, identifier NCT03315286.
Chronic alcohol-induced long-lasting working memory deficits are associated with altered histone H3K9 dimethylation in the prefrontal cortex
Authors: De Clerck Mael , Manguin Martin , Henkous Nadia , d’Almeida Marion N. , Beracochea Daniel , Mons Nicole 
Published: March 2024

IntroductionEpigenetic modifications have emerged as key contributors to the enduring behavioral, molecular and epigenetic neuroadaptations during withdrawal from chronic alcohol exposure. The present study investigated the long-term consequences of chronic alcohol exposure on spatial working memory (WM) and associated changes of transcriptionally repressive histone H3 lysine 9 dimethylation (H3K9me2) in the prefrontal cortex (PFC).MethodsMale C57BL/6 mice were allowed free access to either 12% (v/v) ethanol for 5 months followed by a 3-week abstinence period or water. Spatial WM was assessed through the spontaneous alternation T-maze test. Alcoholic and water mice received daily injections of GABAB agonist baclofen or saline during alcohol fading and early withdrawal. Global levels of histone modifications were determined by immunohistochemistry.ResultsWithdrawal mice displayed WM impairments along with reduced prefrontal H3K9me2 levels, compared to water-drinking mice. The withdrawal-induced decrease of H3K9me2 occurred concomitantly with increased level of permissive H3K9 acetylation (H3K9ac) in the PFC. Baclofen treatment rescued withdrawal-related WM deficits and fully restored prefrontal H3K9me2 and H3K9ac. Alcohol withdrawal induced brain region-specific changes of H3K9me2 and H3K9ac after testing, with significant decreases of both histone marks in the dorsal hippocampus and no changes in the amygdala and dorsal striatum. Furthermore, the magnitude of H3K9me2 in the PFC, but not the hippocampus, significantly and positively correlated with individual WM performances. No correlation was observed between H3K9ac and behavioral performance. Results also indicate that pre-testing intraperitoneal injection of UNC0642, a selective inhibitor of histone methyltransferase G9a responsible for H3K9me2, led to WM impairments in water-drinking and withdrawal-baclofen mice. Collectively, our results demonstrate that alcohol withdrawal induced brain-region specific alterations of H3K9me2 and H3K9ac, an effect that persisted for at least three weeks after cessation of chronic alcohol intake.ConclusionThe findings suggest a role for long-lasting decreased H3K9me2 specifically in the PFC in the persistent WM impairments related to alcohol withdrawal.
An integrative morpho-molecular approach in malignant ectomesenchymoma diagnosis: report of a new paediatric case and a review of the literature
Authors: Pellegrino Francesco , Tirtei Elisa , Divincenzo Federico , Campello Anna , Rubino Carlotta , Augustoni Elisabetta , Linari Alessandra , Asaftei Sebastian Dorin , Fagioli Franca 
Published: March 2024

IntroductionMalignant ectomesenchymoma (MEM) is a soft tissue tumour, consisting of both malignant neuroectodermal elements and one or more mesenchymal elements.Case presentation and review of the literatureHere we describe the case of a 6-months-old male, previously treated in another hospital for abdominal rhabdomyosarcoma (RMS). Histological re-examination demonstrated that the tumour had mesenchymal and neuroectodermal elements components, with a new diagnosis of abdominal-pelvic MEM. A Next-Generation Sequencing (NGS) analysis was performed on a surgical tumour specimen and revealed the presence of a somatic mutation, already reported in MEM cases. We carried out a review of the literature and we found 33 new cases of MEM since the last review. We reported the clinic-pathologic features of new cases of MEM, highlighting the role of molecular studies in supporting the diagnosis of this ambiguous tumours.ConclusionWe promote the importance of a diagnosis based on an integrative morpho-molecular approach, that routinely include molecular analysis and the use of bioinformatic mutation detection tools, to support diagnostic and therapeutical queries and to highlight tumour biology and behaviour.
A causality between fruit consumption and colorectal cancer: a two-sample Mendelian randomization analysis
Authors: Yang Li 
Published: March 2024

BackgroundColorectal cancer (CRC) significantly threatens human health with increasing incidence and mortality. A debate continues whether fruit consumption is associated with CRC, despite dietary habits having an impact on the disease. The study aims to examine the causal relationship between fruit consumption and CRC based on a two-sample Mendelian randomization method (MR).MethodsSummary statistics for fruit consumption and CRC were obtained from the UK Biobank and the FinnGen Consortium, respectively. Analysis methods used in this study included the inverse-variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode. Heterogeneity and horizontal pleiotropy were also assessed. Additionally, a leave-one-out analysis was performed to validate the robustness of the results.ResultsWe found that fruit consumption was associated with a reduction in CRC risk by the IVW method (P = 0.021). This protective effect was predominantly observed in males (OR 0.374; 95% CI: 0.157-0.892; P = 0.027), while no protective effect was noted in females. However, causal correlations were not observed upon analyzing 16 individual types of fruits. Moreover, our results were unlikely to be influenced by horizontal pleiotropy and heterogeneity. Leave-one-out analysis confirmed the stability of the results.ConclusionOur findings suggest that a genetic predisposition for fruit consumption may be protective against CRC, underscoring the need for further research to elucidate the underlying mechanisms and dietary patterns involved.
Targeted intracellular delivery of dimeric STINGa by two pHLIP peptides for treatment of solid tumors
Authors: Moshnikova Anna , DuPont Michael , Iraca Marissa , Klumpp Craig , Visca Hannah , Allababidi Dana , Pelzer Phoebe , Engelman Donald M. , Andreev Oleg A. , Reshetnyak Yana K. 
Published: March 2024

Introduction: We have developed a delivery approach that uses two pHLIP peptides that collaborate in the targeted intracellular delivery of a single payload, dimeric STINGa (dMSA).Methods: dMSA was conjugated with two pHLIP peptides via S-S cleavable self-immolating linkers to form 2pHLIP-dMSA.Results: Biophysical studies were carried out to confirm pH-triggered interactions of the 2pHLIP-dMSA with membrane lipid bilayers. The kinetics of linker self-immolation and dMSA release, the pharmacokinetics, the binding to plasma proteins, the stability of the agent in plasma, the targeting and resulting cytokine activation in tumors, and the biodistribution of the construct was investigated. This is the first study demonstrating that combining the energy of the membrane-associated folding of two pHLIPs can be utilized to enhance the targeted intracellular delivery of large therapeutic cargo payloads.Discussion: Linking two pHLIPs to the cargo extends blood half-life, and targeted delivery of dimeric STINGa induces tumor eradication and the development of robust anti-cancer immunity.
Quadriceps muscle atrophy after non-invasive anterior cruciate ligament injury: evidence linking to autophagy and mitophagy
Authors: Noh Sung Gi , Ahn Ahram , Davi Steven M. , Lepley Lindsey K. , Kwon Oh Sung 
Published: March 2024

Introduction: Anterior cruciate ligament (ACL) injury is frequently accompanied by quadriceps muscle atrophy, a process closely linked to mitochondrial health and mitochondria-specific autophagy. However, the temporal progression of key quadricep atrophy-mediating events following ACL injury remains poorly understood. To advance our understanding, we conducted a longitudinal study to elucidate key parameters in quadriceps autophagy and mitophagy.Methods: Long-Evans rats were euthanized at 7, 14, 28, and 56 days after non-invasive ACL injury that was induced via tibial compression overload; controls were not injured. Vastus lateralis muscle was extracted, and subsequent immunoblotting analysis was conducted using primary antibodies targeting key proteins involved in autophagy and mitophagy cellular processes.Results: Our findings demonstrated dynamic changes in autophagy and mitophagy markers in the quadriceps muscle during the recovery period after ACL injury. The early response to the injury was characterized by the induction of autophagy at 14 days (Beclin1), indicating an initial cellular response to the injury. Subsequently, at 14 days we observed increase in the elongation of autophagosomes (Atg4B), suggesting a potential remodeling process. The autophagosome flux was also augmented between 14- and 28 days (LC3-II/LC3-I ratio and p62). Notably, at 56 days, markers associated with the elimination of damaged mitochondria were elevated (PINK1, Parkin, and VDAC1), indicating a possible ongoing cellular repair and restoration process.Conclusion: These data highlight the complexity of muscle recovery after ACL injury and underscore the overlooked but crucial role of autophagy and mitophagy in promoting the recovery process.
Autonomous sensory Meridian response as a physically felt signature of positive and negative emotions
Authors: Leung Wai Lam , Romano Daniela M. 
Published: March 2024

IntroductionCurrent research on Autonomous Sensory Meridian Response (ASMR) assumes that ASMR is always accompanied by contentment, and it is distinct from frisson due to positive emotions. Thus, research investigations tend to limit their scope to solely focusing on the sensation of relaxation that ASMR induces. This study explores whether it is possible to have a different emotional experience and still perceive ASMR, testing the theory of ASMR as an amplifier of pre-existing emotion instead of a determination of positive affect.MethodsThe emotional arousal and valence, and mood changes of 180 ASMR-capable and incapable individuals were analysed using questionnaires after altering the affective interpretation associated with auditory ASMR (tapping) with visual priming to examine whether the primed emotion (fearful, relaxing, or neutral) could be amplified.ResultsIt was found that an ASMR response occurred in all priming conditions, including the fear priming group. No significant difference was found in the emotional outcome or mood of the neutral and relaxing priming groups. Upon comparison with ASMR-incapable individuals, both the relaxing and neutral priming groups demonstrated the same affect, but greater potent for ASMR-capable. Individuals who appraised ASMR after visual fear priming demonstrated a significant decrease in positive emotional valence and increased arousal.ConclusionThe findings suggest that ASMR occurs in both positive and negative emotional situations, suppressing contentment induction if ASMR stimuli are interpreted negatively and amplifying contentment when interpreted positively. While more research is needed, the results highlight that ASMR and frisson might describe the same phenomenon, both a physically felt signature of emotion. Therapeutic usage of ASMR should carefully select appropriate stimuli that emphasise contentment to avoid potential health risks associated with negative emotions until a further understanding of ASMR’s affective parameters has been established.
Psychometric properties of the wellbeing literacy 6-item scale in Chinese military academy cadets
Authors: Jia Zhen , Zheng Fangfang , Wang Feifei , Yang Guoyu 
Published: March 2024

BackgroundPositive psychology is a vibrant field of study, and conceptualizations of the components of well-being have received a great deal of attention from researchers. The study of well-being literacy thus provides an innovative perspective for enhancing and sustaining individuals’ experiences of well-being.ObjectiveThis study aimed to examine the psychometric properties of the wellbeing literacy 6-item (Well-Lit 6) scale in Chinese military academy cadets.MethodsA total of 3,218 undergraduate students from five military academies in China were recruited to complete questionnaires online.Results(1) The items of the scale showed high discrimination; (2) The alpha coefficient of the scale was 0.986 and the split-half reliability was 0.981, indicating high homogeneous reliability and split-half reliability; (3) The scale model fitted well and displayed structural validity; (4) The correlation between well-being literacy and related indicators was significant, and the calibration correlation and convergent-discriminant validity of the scale were high; (5) After gradually adding demographic variables, known predictors factors and well-being literacy, the ∆R2 for subjective well-being, life satisfaction, depression, and anxiety ranged from 0.036 to 0.067, 0.184 to 0.340, and 0.009 to 0.017, respectively, showing high incremental validity; (6) the total well-being literacy scores differed significantly by gender, grade, and parenting style.ConclusionThe Chinese version of the Well-Lit 6 is reliable and valid in predicting and accessing the subjective well-being, life satisfaction, emotion regulation, and psychological resilience of Chinese military academy cadets.
Stress and sport performance: a PNEI multidisciplinary approach
Authors: Tossici Giulia , Zurloni Valentino , Nitri Andrea 
Published: March 2024

Stress control is essential for avoiding a state of anxiety in sport competitions, as this state may have negative effects on other psychological variables of athletes, decreasing their self-confidence and harming their attentional control. In the present contribution a distress intervention model developed from a PNEI perspective will be sketched out. Our theoretical-methodological proposal consists of the definition of an integrated protocol of psycho-biological assessment and intervention on the allostatic load and on the levels of distress/eustress detectable in the sport environment, in relation to the person’s health/well-being condition and the impact of this condition on the quality of sport performance.This paradigm has the potential to explore both the psychological dimension of stress management and the psycho-educational and psycho-physical dimension, according to a truly integrated approach to the athlete’s health and psychophysical well-being. Its multidisciplinary nature requires close cooperation between different professional figures, such as the mental coach, psychologist, nutritionist, osteopath, and physiotherapist, as well as biologists, physicians and kinesiologists, both in planning and in implementation and monitoring at all stages. The potential impact of the model on sport performance will be deeply discussed.
How does mobility and urban environment affect the migrants’ settlement intention? A perspective from the intergenerational differences
Authors: Liang Xiaoxiang , Li Qingyin , Zuo Wen , Wu Rong 
Published: March 2024

IntroductionWith China embracing a new people-centered urbanization stage, the problem of migrants “flowing without moving” has become increasingly prominent, and settlement intention has gradually garnered attention.MethodsOur research, based on questionnaire data from the China Labor Force Dynamic Survey 2016, uses a multilevel linear regression model to explore the influence of mobility, social environment, built environment, and demographics characteristics on settlement intention in the migrants and discusses differences between settlement intention of new and old generations and their internal influence mechanism.ResultsThe findings are as follows: (1) Compared to the old generation, the new migrant generation generally has higher settlement intention. (2) The migrants’ settlement intention is influenced mainly by mobility, social environment, built environment, and demographic characteristics. (3) For the new migrant generation, social and demographic characteristics significantly influence their settlement intention. (4) The floating and built environment of the old generation significantly influence their settlement intention.DiscussionFinally, this paper argues that there are differences in the influence mechanism of the same factors on the settlement intention of the new and old generations of migrants. It proposes differentiated policy suggestions for the migrants to promote city social integration. Finally, this paper argues that there are differences in the influence mechanism of the same factors on the settlement intention of the new and old generations of migrants. It proposes differentiated policy suggestions for the migrants to promote city social integration.
Rancang Bangun Radar 360 Derajat Berbasis Arduino
Authors: Winardi Slamet , Kristiyono Antonius Edy , Herlambang Sri Mulyanto , Budijanto Arief 
Published: March 2024

Pada penelitian ini dibuat suatu alat simulator radar yang menggunakan komponen utama mikrokontroler arduino nano dan untuk mendeteksi serta mengukur jarak obyek yang tertangkap simulator radar menggunakan sensor ultrasonic. Sensor ultrasonic yang digunakan untuk menangkap obyek dikopel dengan motor DC servo agar dapat digerakkan kearah kanan dan kiri dengan simpangan sudut 360°. Permasalahan yang terjadi dengan putaran 360O adalah mengatasi terlilitnya kabel sensor ultrasonic dalam mekanis radar tersebut. Sehingga dibuat dua buah lempengan yang akan menghunbungkan lempengan yang statis dan lempengan yang dinamis dengan empat jalur untuk koneksi ke terminal sensor. Visualisasi obyek yang tertangkap radar (sensor ultrasonic) akan ditampilkan pada layar komputer dengan visualisasi grafik dan memberikan tanda beep setiap menangkap obyek yang ada di depan sensor. Simulasi ini dibuat untuk mendeteksi benda sampai pada jarak 40 cm, dengan membuat skala 1:10 sehingga 40 cm sama dengan 4 meter. Perangkat lunak yang digunakan memvisualkan obyek yang tertangkap radar Arduino menggunakan Processing karena software ini sangat mudah komunikasi antar platform. Hasil pengujian alat ssudah sesuai dengan tujuan, tetapi masih memiliki rata-rata kesalahan dalam melekukan pengukuran jarak sebesar 0,225.
Studying the adequacy of the neural network level controller in the automated control system of an evaporator
Authors: Hrama Mykhailo , Sidletskyi Viktor 
Published: March 2024

The aim of the study is to substantiate the use of neural network control of beet juice level in an evaporator by evaluating the accuracy and adequacy of the model. This allows us to assess how well the model properties describe the course of the real process. The use of mathematical statistics methods is the most common way to test models for adequacy. In the automation scheme of level control, capacitive level gauges are used as a sensor. The actuators are pneumatic seat valves with a built-in throttle and an electropneumatic converter. The use of neural network controllers is found only in some specific cases of intelligent control of the evaporation process, and there are no data comparing the use of intelligent controllers with classical ones. In this paper, the Durbin-Watson d-criterion is used to assess the adequacy of the model. Statistical data on the behavior of the level control system circuits in different operating modes using intelligent and classical controllers were collected and a model of the evaporator unit operation was built. The advantage of the Durbin-Watson criterion is its simple and fast implementation, which does not require large economic and energy costs. The accuracy of the model was also evaluated. The static error of the control quality for the levels in the five enclosures of 25–65 % (in 10 % increments) is within the range of no more than 0,2 %. The proposed model of the evaporator station operation is generally characterized by high accuracy.
Current State of Endocrinology Service of the Republic of Belarus
Authors: Салко О.Б. , Солнцева А.В. , Шепелькевич А.П. , Пацеев А.В. , Кузьменкова Е.И. , Залесская О.Г. , Григорович А.С. , Селиванов В.Н. , Ковшик Л.П. , Юреня Е.В. , Педченец Л.М. , Осовик Г.А. 
Published: March 2024

В статье представлены данные о порядке организации медицинской помощи пациентам с заболеваниями эндокринной системы с выделением особенностей оказания медицинской помощи в амбулаторных и стационарных условиях. Проанализированы данные о распространенности эндокринной патологии в целом и о сахарном диабете в частности. Охарактеризована целесообразность использования данных республиканского регистра «Сахарный диабет», которые позволили оптимизировать лечебно-диагностические технологии в ведении пациентов с сахарным диабетом, в частности, в улучшении качества обучения, изменении подходов к инсулинотерапии, расширении показаний к назначению аналогов инсулина и доступности средств самоконтроля. Также определены основные задачи по совершенствованию оказания эндокринологической помощи на современном этапе.
The article presents data on the procedure for organizing medical care for patients with endocrine diseases, highlighting the features of providing medical care in outpatient and inpatient settings. Data on the prevalence of endocrine pathology in general and, in particular, diabetes mellitus were analyzed. The feasibility of using data from the republican register "Diabetes Mellitus", which made it possible to optimize therapeutic and diagnostic technologies in the management of patients with diabetes mellitus, is characterized. In particular, improving the quality of training, changing approaches to insulin therapy, expanding the indications for prescribing insulin analogues and the availability of self-monitoring tools. The main tasks for improving the provision of endocrinological care at the present stage are also identified.