bluuebunny/crossref_metadata_2025_split huggingface dataset:
Separable Forms of Reality Monitoring Supported by Anterior Prefrontal Cortex
Authors: Simons Jon S. , Henson Richard N. A. , Gilbert Sam J. , Fletcher Paul C. 
Published: November 2007

Abstract
Reality monitoring refers to the process of discriminating between internally and externally generated information. Two different tasks have often been used to assess this ability: (a) memory for perceived versus imagined stimuli; and (b) memory for participant- versus experimenter-performed operations. However, it is not known whether these two reality monitoring tasks share neural substrates. The present study involved use of a within-subjects functional magnetic resonance imaging design to examine common and distinct brain mechanisms associated with the two reality monitoring conditions. The sole difference between the two lay in greater activation in the medial anterior prefrontal cortex when recollecting whether the participant or the experimenter had carried out an operation during prior encoding as compared to recollecting whether an item had been perceived or imagined. This region has previously been linked with attending to mental states. Task differences were also reflected in the nature of functional connectivity relationships between the medial anterior and right lateral prefrontal cortex: There was a stronger correlation in activity between the two regions during recollection of self/experimenter context. This indicates a role for the medial anterior prefrontal cortex in the monitoring of retrieved information relating to internal or external aspects of context. Finally, given the importance of reality monitoring to understanding psychotic symptoms, brain activity was related to measures of proneness to psychosis and schizotypal traits. The observation of significant correlations between reduced medial anterior prefrontal signal and scores on such measures corroborates these theoretical links.
Multipoint Explicit Differencing (MED) for Time Integrations of the Wave Equation
Authors: Konor Celal S. , Arakawa Akio 
Published: November 2007

Abstract
For time integrations of the wave equation, it is desirable to use a scheme that is stable over a wide range of the Courant number. Implicit schemes are examples of such schemes, but they do that job at the expense of global calculation, which becomes an increasingly serious burden as the horizontal resolution becomes higher while covering a large horizontal domain. If what an implicit scheme does from the point of view of explicit differencing is looked at, it is a multipoint scheme that requires information at all grid points in space. Physically this is an overly demanding requirement because wave propagation in the real atmosphere has a finite speed. The purpose of this study is to seek the feasibility of constructing an explicit scheme that does essentially the same job as an implicit scheme with a finite number of grid points in space. In this paper, a space-centered trapezoidal implicit scheme is used as the target scheme as an example. It is shown that an explicit space-centered scheme with forward time differencing using an infinite number of grid points in space can be made equivalent to the trapezoidal implicit scheme. To avoid global calculation, a truncated version of the scheme is then introduced that only uses a finite number of grid points while maintaining stability. This approach of constructing a stable explicit scheme is called multipoint explicit differencing (MED). It is shown that the coefficients in an MED scheme can be numerically determined by single-time-step integrations of the target scheme. With this procedure, it is rather straightforward to construct an MED scheme for an arbitrarily shaped grid and/or boundaries. In an MED scheme, the number of grid points necessary to maintain stability and, therefore, the CPU time needed for each time step increase as the Courant number increases. Because of this overhead, the MED scheme with a large time step can be more efficient than a usual explicit scheme with a smaller time step only for complex multilevel models with detailed physics. The efficiency of an MED scheme also depends on how the advantage of parallel computing is taken.
The Three-Dimensional Structure and Kinematics of Drizzling Stratocumulus
Authors: Comstock Kimberly K. , Yuter Sandra E. , Wood Robert , Bretherton Christopher S. 
Published: November 2007

Abstract
Drizzling marine stratocumulus are examined using observations from the 2001 East Pacific Investigation of Climate Stratocumulus (EPIC Sc) field experiment. This study uses a unique combination of satellite and shipborne Doppler radar data including both horizontal and vertical cross sections through drizzle cells. Stratocumulus cloud structure was classified as closed cellular, open cellular, or unclassifiable using infrared satellite images. Distributions of drizzle cell structure, size, and intensity are similar among the cloud-structure categories, though the open-cellular distributions are shifted toward higher values. Stronger and larger drizzle cells preferentially occur when the cloud field is broken (open-cellular and unclassifiable categories). Satellite observations of cloud structure may be useful to indicate the most likely distribution of rain rates associated with a set of scenes, but infrared data alone are not sufficient to develop routine precipitation retrievals for marine stratocumulus. Individual drizzle cells about 2–20 km across usually showed precipitation growth within the cloud layer and evaporation below, divergence near echo top, and convergence below cloud base. Diverging flow near the surface was also observed beneath heavily precipitating drizzle cells. As the cloud field transitioned from a closed to an open-cellular cloud structure, shipborne radar revealed prolific development of small drizzle cells (&lt;10 km2) that exceeded by over 5 times the number of total cells in either the preceding closed-cellular or following open-cellular periods. Peak area-average rain rates lagged by a few hours the peak in total number of drizzle cells. Based on observations from EPIC Sc, the highest stratocumulus rain rates are more likely to occur near the boundary between closed and open-cellular cloud structures.
Evaluation of Precipitation from Numerical Weather Prediction Models and Satellites Using Values Retrieved from Radars
Authors: Vasić Slavko , Lin Charles A. , Zawadzki Isztar , Bousquet Olivier , Chaumont Diane 
Published: November 2007

Abstract
Precipitation is evaluated from two weather prediction models and satellites, taking radar-retrieved values as a reference. The domain is over the central and eastern United States, with hourly accumulated precipitation over 21 days for the models and radar, and 13 days for satellite. Conventional statistical measures and scale decomposition methods are used. The models generally underestimate strong precipitation and show nearly constant modest skill over a 24-h forecast period. The scale decomposition results show that the effective model resolution for precipitation is many times the grid size. The model predictability extends beyond a few hours for only the largest scales.
A Spectral Element Version of CAM2
Authors: Wang Houjun , Tribbia Joseph J. , Baer Ferdinand , Fournier Aimé , Taylor Mark A. 
Published: November 2007

Abstract
The authors describe a recent development and some applications of a spectral element dynamical core. The improvements and development include the following: (i) the code was converted from FORTRAN 77 to FORTRAN 90; (ii) the dynamical core was extended to the generalized terrain-following, or hybrid η, vertical coordinates; (iii) a fourth-order Runge–Kutta (RK4) method for time integration was implemented; (iv) moisture effects were added in the dynamical system and a semi-Lagrangian method for moisture transport was implemented; and (v) the improved dynamical core was coupled with the Community Atmosphere Model version 2 (CAM2) physical parameterizations and Community Land Model version 2 (CLM2) in such a way that it can be used as an alternative dynamical core in CAM2. This spectral element version of CAM2 is denoted as CAM-SEM. A mass fixer as used in the Eulerian version of CAM2 (CAM-EUL) is also implemented in CAM-SEM. Results from multiyear simulations with CAM-SEM (coupled with CLM2) with climatology SST are also presented and compared with simulations from CAM-EUL. Close resemblances are shown in simulations from CAM-SEM and CAM-EUL. The authors found that contrary to what is suggested by some other studies, the high-order Lagrangian interpolation (with a limiter) using the spectral element basis functions may not be suitable for moisture and other strongly varying fields such as cloud and precipitation.
Combination of Mesoscale and Synoptic Mechanisms for Triggering an Isolated Thunderstorm: Observational Case Study of CSIP IOP 1
Authors: Morcrette Cyril , Lean Humphrey , Browning Keith , Nicol John , Roberts Nigel , Clark Peter , Russell Andrew , Blyth Alan 
Published: November 2007

Abstract
An isolated thunderstorm formed in the southern United Kingdom on 15 June 2005 and moved through the area where a large number of observational instruments were deployed as part of the Convective Storm Initiation Project. Earlier, a convergence line had formed downstream of Devon in the southwest of the United Kingdom in a southwesterly airflow, along which a series of light showers had formed. The depth of these showers was limited by a capping inversion, or lid, at around 2.5 km. The deep thunderstorm convection developed from one of these showers when the convection broke through the lid and ascended up to the next inversion, associated with a tropopause fold at around 6 km. A series of clear-air reflectivity RHIs are used to map the height of the capping inversion and its lifting resulting from the ascent along the convergence line. The origins of the lid are tracked back to some descent from the midtroposphere along dry adiabats. The strength of the lid was weaker along a northwest-to-southeast-oriented region located behind an overrunning upper cold front. The transition from shallow to deep convection occurred where this region with a weaker lid intersected the region with a raised lid, oriented southwest to northeast, downstream of Devon. A very high resolution forecast model that is being developed by the Met Office predicted the isolated thunderstorm successfully. This success depended on the accurate representation of the following two scales: the synoptic-scale and the surface-forced mesoscale convergence line. The interaction between these scales localized the convection sufficiently in space and time for the initiation and subsequent development to be highly predictable despite the relatively poor representation in the model of processes at the cloud scale.
Explicit Numerical Diffusion in the WRF Model
Authors: Knievel Jason C. , Bryan George H. , Hacker Joshua P. 
Published: November 2007

AbstractDiffusion that is implicit in the odd-ordered advection schemes in early versions of the Advanced Research core of the Weather Research and Forecasting (WRF) model is sometimes insufficient to remove noise from kinematical fields. The problem is worst when grid-relative wind speeds are low and when stratification is nearly neutral or unstable, such as in weakly forced daytime boundary layers, where noise can grow until it competes with the physical phenomena being simulated. One solution to this problem is an explicit, sixth-order numerical diffusion scheme that preserves the WRF model’s high effective resolution and uses a flux limiter to ensure monotonicity. The scheme, and how it was added to the WRF model, are explained. The scheme is then demonstrated in an idealized framework and in simulations of salt breezes and lake breezes in northwestern Utah.
Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a phase 1-2 study
Authors: Coiffier Bertrand , Lepretre Stéphane , Pedersen Lars Møller , Gadeberg Ole , Fredriksen Henrik , van Oers Marinus H. J. , Wooldridge James , Kloczko Janusz , Holowiecki Jerzy , Hellmann Andrzej , Walewski Jan , Flensburg Mimi , Petersen Jørgen , Robak Tadeusz 
Published: November 2007

Abstract
Safety and efficacy of the fully human anti-CD20 monoclonal antibody, ofatumumab, was analyzed in a multicenter dose-escalating study including 33 patients with relapsed or refractory chronic lymphocytic leukemia. Three cohorts of 3 (A), 3 (B), and 27 (C) patients received 4, once weekly, infusions of ofatumumab at the following doses: (A) one 100 mg and three 500 mg; (B) one 300 mg and three 1000 mg; (C) one 500 mg and three 2000 mg. Sixty-seven percent of the patients were Binet stage B, and the median number of previous treatments was 3. The maximum tolerated dose was not reached. The majority of related adverse events occurred at first infusion, and the number of adverse events decreased at each subsequent infusion. Seventeen (51%) of 33 patients experienced infections, 88% of them of grade 1-2. One event of interstitial pneumonia was fatal; all other cases resolved within one month. The response rate of cohort C was 50% (13/26), one patient having a nodular partial remission and 12 patients partial remission. In conclusion, ofatumumab was found to be well tolerated in patients with chronic lymphocytic leukemia (CLL) in doses up to 2000 mg. Preliminary data on safety and objective response are encouraging and support further studies on the role of ofatumumab in CLL patients. This trial was registered at www.clinicaltrials.gov as no. NCT00093314.
Predicting combinatorial binding of transcription factors to regulatory elements in the human genome by association rule mining
Authors: Morgan Xochitl C , Ni Shulin , Miranker Daniel P , Iyer Vishwanath R 
Published: November 2007

AbstractBackgroundCis-acting transcriptional regulatory elements in mammalian genomes typically contain specific combinations of binding sites for various transcription factors. Although some cis-regulatory elements have been well studied, the combinations of transcription factors that regulate normal expression levels for the vast majority of the 20,000 genes in the human genome are unknown. We hypothesized that it should be possible to discover transcription factor combinations that regulate gene expression in concert by identifying over-represented combinations of sequence motifs that occur together in the genome. In order to detect combinations of transcription factor binding motifs, we developed a data mining approach based on the use of association rules, which are typically used in market basket analysis. We scored each segment of the genome for the presence or absence of each of 83 transcription factor binding motifs, then used association rule mining algorithms to mine this dataset, thus identifying frequently occurring pairs of distinct motifs within a segment.ResultsSupport for most pairs of transcription factor binding motifs was highly correlated across different chromosomes although pair significance varied. Known true positive motif pairs showed higher association rule support, confidence, and significance than background. Our subsets of high-confidence, high-significance mined pairs of transcription factors showed enrichment for co-citation in PubMed abstracts relative to all pairs, and the predicted associations were often readily verifiable in the literature.ConclusionFunctional elements in the genome where transcription factors bind to regulate expression in a combinatorial manner are more likely to be predicted by identifying statistically and biologically significant combinations of transcription factor binding motifs than by simply scanning the genome for the occurrence of binding sites for a single transcription factor.
Characterization, developmental expression and evolutionary features of the huntingtin gene in the amphioxus Branchiostoma floridae
Authors: Candiani Simona , Pestarino Mario , Cattaneo Elena , Tartari Marzia 
Published: November 2007

Abstract
Background
Huntington's disease is an inherited neurodegenerative disorder that is caused by the expansion of an N-terminal polyQ stretch in the huntingtin protein. In order to investigate the hypothesis that huntingtin was already involved in development of the nervous system in the last common ancestor of chordates, we isolated and characterised the huntingtin homologue from the amphioxus Branchiostoma floridae. In the present paper the amphioxus general term must be referred to Branchiostoma floridae.

Results
In this report, we show that the exon-intron organization of the amphioxus huntingtin gene is highly conserved with that of other vertebrates species. The AmphiHtt protein has two glutamine residues in the position of the typical vertebrate polyQ tract. Sequence conservation is greater along the entire length of the protein than in a previously identified Ciona huntingtin. The first three N-terminal HEAT repeats are highly conserved in vertebrates and amphioxus, although exon rearrangement has occurred in this region. AmphiHtt expression is detectable by in situ hybridization starting from the early neurula stage, where it is found in cells of the neural plate. At later stages, it is retained in the neural compartment but also it appears in limited and well-defined groups of non-neural cells. At subsequent larval stages, AmphiHtt expression is detected in the neural tube, with the strongest signal being present in the most anterior part.

Conclusion
The cloning of amphioxus huntingtin allows to infer that the polyQ in huntingtin was already present 540 million years ago and provides a further element for the study of huntingtin function and its evolution along the deuterostome branch.
Developing health science students into integrated health professionals: a practical tool for learning
Authors: Olckers Lorna , Gibbs Trevor J , Duncan Madeleine 
Published: November 2007

Abstract

Background
An integrated sense of professionalism enables health professionals to draw on relevant knowledge in context and to apply a set of professional responsibilities and ethical principles in the midst of changing work environments [1, 2]. Inculcating professionalism is therefore a critical goal of health professional education. Two multi-professional courses for first year Health Science students at the University of Cape Town, South Africa aim to lay the foundation for becoming an integrated health professional [3]. In these courses a diagram depicting the domains of the integrated health professional is used to focus the content of small group experiential exercises towards an appreciation of professionalism. The diagram serves as an organising framework for conceptualising an emerging professional identity and for directing learning towards the domains of 'self as professional' [4, 5].

Objective
This paper describes how a diagrammatic representation of the core elements of an integrated health professional is used as a template for framing course content and for organising student learning. Based on the assumption that all health care professionals should be knowledgeable, empathic and reflective, the diagram provides students and educators with a visual tool for investigating the subjective and objective dimensions of professionalism. The use of the diagram as an integrating point of reference for individual and small group learning is described and substantiated with relevant literature.

Conclusion
The authors have applied the diagram with positive impact for the past six years with students and educators reporting that "it just makes sense". The article includes plans for formal evaluation. Evaluation to date is based on preliminary, informal feedback on the value of the diagram as a tool for capturing the domains of professionalism at an early stage in the undergraduate education of health professional students.
Dental practice satisfaction with preferred provider organizations
Authors: Aseltine Robert H , Reisine Susan , Schilling Elizabeth A , Kennedy James 
Published: November 2007

AbstractBackgroundDespite their increasing share of the dental insurance market, little is known about dental practices' satisfaction with preferred provider organizations (PPOs). This analysis examined practice satisfaction with dental PPOs and the extent to which satisfaction was a function of communications from the plan, claims handling and compensation.MethodsData were collected through telephone surveys with dental practices affiliated with MetLife between January 2002 and December 2004. Each respondent was asked a series of questions related to their satisfaction with a systematically selected PPO with which they were affiliated. Six different PPO plans had sufficient observations to allow for comparative analysis (total n = 4582). Multiple imputation procedures were used to adjust for item non-response.ResultsWhile the average level of overall satisfaction with the target plan fell between "very satisfied" and "satisfied," regression models revealed substantial differences in overall satisfaction across the 6 PPOs (p < .05). Statistically significant differences between plans in overall satisfaction were largely explained by differences in the perceived adequacy of compensation. However, differences in overall satisfaction involving two of the PPOs were also driven by satisfaction with claims handling.ConclusionResults demonstrate the importance of compensation to dental practice satisfaction with PPOs. However, these results also highlight the critical role of service-related factors in differentiating plans and suggest that there are important non-monetary dimensions of PPO performance that can be used to recruit and retain practices.
Efficacy and safety of artesunate plus amodiaquine in routine use for the treatment of uncomplicated malaria in Casamance, southern Sénégal
Authors: Brasseur Philippe , Agnamey Patrice , Gaye Oumar , Vaillant Michel , Taylor Walter RJ , Olliaro Piero L 
Published: November 2007

Abstract

Background
There are no data on the long term use of an artemisinin combination treatment in moderate or high transmission areas of Africa.

Methods and findings
Artesunate plus amodiaquine (AS+AQ) was used to treat slide-proven Plasmodium falciparum-infected patients of all ages in the Oussouye district, Casamance, Senegal, over a period of six years (2000 to 2005). Efficacy, by Kaplan Meier survival analysis (n = 966), and safety (adverse event rates, n = 752) were determined over 28 days. A weight-based dosing regimen was used for the loose tablets during 2000–2003 (n = 731) and a commercially available co-blister was used during 2004–2005 (n = 235).
Annual crude (non PCR corrected) rates remained stable over the study period [range 88.5–96.7%; overall 94.6 (95% CI 92.9–95.9)]. Nine co-blister treated patients (0.9%) withdrew because of drug-related adverse events; seven had gastrointestinal complaints of whom two were hospitalized for vomiting. By Day 28, the mean total bilirubin (n = 72), AST (n = 94) and ALT (n = 95) values decreased. Three patients had Day 28 AST/ALT values > 40 < 200 IU/L. Changes in white cell counts were unremarkable (n = 87).

Conclusion
AS+AQ in combination was highly efficacious and well-tolerated in this area and justifies the decision to use it as first line treatment. Long-term monitoring of safety and efficacy should continue.