bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammation in obsessive–compulsive disorder: A literature review and hypothesis‐based potential of transcranial photobiomodulation
Authors: Coelho David Richer Araujo , Salvi Joshua D. , Vieira Willians Fernando , Cassano Paolo 
Published: March 2024

AbstractObsessive–compulsive disorder (OCD) is a disabling neuropsychiatric disorder that affects about 2%–3% of the global population. Despite the availability of several treatments, many patients with OCD do not respond adequately, highlighting the need for new therapeutic approaches. Recent studies have associated various inflammatory processes with the pathogenesis of OCD, including alterations in peripheral immune cells, alterations in cytokine levels, and neuroinflammation. These findings suggest that inflammation could be a promising target for intervention. Transcranial photobiomodulation (t‐PBM) with near‐infrared light is a noninvasive neuromodulation technique that has shown potential for several neuropsychiatric disorders. However, its efficacy in OCD remains to be fully explored. This study aimed to review the literature on inflammation in OCD, detailing associations with T‐cell populations, monocytes, NLRP3 inflammasome components, microglial activation, and elevated proinflammatory cytokines such as TNF‐α, CRP, IL‐1β, and IL‐6. We also examined the hypothesis‐based potential of t‐PBM in targeting these inflammatory pathways of OCD, focusing on mechanisms such as modulation of oxidative stress, regulation of immune cell function, reduction of proinflammatory cytokine levels, deactivation of neurotoxic microglia, and upregulation of BDNF gene expression. Our review suggests that t‐PBM could be a promising, noninvasive intervention for OCD, with the potential to modulate underlying inflammatory processes. Future research should focus on randomized clinical trials to assess t‐PBM's efficacy and optimal treatment parameters in OCD. Biomarker analyses and neuroimaging studies will be important in understanding the relationship between inflammatory modulation and OCD symptom improvement following t‐PBM sessions.
A novel approach to evaluation of tumor response for advanced pulmonary adenocarcinoma using the intertumoral heterogeneity response score
Authors: Zheng Xinlong , Lu Tao , Wu Shiwen , Lin Xiaoyan , Bai Jing , Chen Xiaohui , Miao Qian , Yan Jianqun , Jiang Kan , Zhang Longfeng , Zheng Xiaobing , Wang Haibo , Xu Yiquan , Xiao Weijin , Li Cao , Peng Wenying , Ding Jianming , Zhong Qiaofeng , Zou Zihua , Yang Shanshan , Li Yujing , Chen Sihui , Zhang Qiuyu , Yan Jianfeng , Tang Guofeng , Cai Yuandong , kang Miao , Mok Tony S. K. , Lin Gen 
Published: March 2024

AbstractTreatment response and prognosis estimation in advanced pulmonary adenocarcinoma are challenged by the significant heterogeneity of the disease. The current Response Evaluation Criteria in Solid Tumors (RECIST) criteria, despite providing a basis for solid tumor response evaluation, do not fully encompass this heterogeneity. To better represent these nuances, we introduce the intertumoral heterogeneity response score (THRscore), a measure built upon and expanding the RECIST criteria. This retrospective study included patients with 3–10 measurable advanced lung adenocarcinoma lesions who underwent first‐line chemotherapy or targeted therapy. The THRscore, derived from the coefficient of variation in size for each measurable tumor before and 4–6 weeks posttreatment, unveiled a correlation with patient outcomes. Specifically, a high THRscore was associated with shorter progression‐free survival, lower tumor response rate, and a higher tumor mutation burden. These associations were further validated in an external cohort, confirming THRscore's effectiveness in stratifying patients based on progression risk and treatment response, and enhancing the utility of RECIST in capturing complex tumor behaviors in lung adenocarcinoma. These findings affirm the promise of THRscore as an enhanced tool for tumor response assessment in advanced lung adenocarcinoma, extending the RECIST criteria's utility.
The role of industrial symbiosis on consumer demand under ecological carbon fixation: Evidence from the energy industry
Authors: Qiu Wei , Zhao Xinyu , Wu Haitao , Ren Siyu 
Published: March 2024

AbstractSince the energy sector is the primary source of carbon emissions, achieving low carbon emission reduction and meeting the carbon peak and carbon neutrality targets require a full grasp of the symbiotic relationship between the traditional and new energy industries. This study analyzes data from China's conventional energy industries and the new energy industry from 2005 to 2021 to examine the symbiosis between these two sectors of the economy and its implications. The Lotka–Volterra model is used to determine the symbiosis between industries and further select provinces with industrial symbiosis to analyze the relationship between industrial symbiosis and consumer demand. The results show that, first, 28 provinces in China have industrial symbiosis, of which only four provinces are commensal symbiosis and the remaining 24 provinces are parasitic symbiosis. Second, whereas the parasitic symbiosis will impede the growth of consumer demand, the commensal symbiosis between the new energy industry and the traditional energy industry can greatly encourage the growth of consumer demand. In addition, the promotion effect of commensal symbiosis on consumer demand is mainly manifested in government consumption, while parasitic symbiosis has a dampening effect on residential consumption, government consumption, and investment. Finally, under the regulation of ecological carbon sequestration, parasitic symbiosis can promote the growth of consumer demand. Therefore, the government should continue to promote industrial symbiosis and ecological carbon sequestration and, in this way, promote the growth of consumer demand.
Electrically tunable substrate integrated waveguide equalizer based on PIN diodes
Authors: Peng Hao , Zhang Chen , Liu Yu , Tatu Serioja Ovidiu , Yang Tao 
Published: March 2024

AbstractIn this letter, a novel design of electrically tunable substrate integrated waveguide (SIW) equalizer, based on PIN diodes, is proposed. Compared to previous SIW equalizers, this one introduces PIN diodes that exhibit varying impedance under different direct current (DC) voltages. The equalizing values of the SIW equalizer are directly linked to the DC voltage applied to the PIN diode within a specific voltage range. This feature allows it to be considered as an electrically tunable SIW equalizer. The experimental results demonstrate that the equalizing values are consistently monotonic and adjustable within the range of 1.59–7.56 dB in Ku‐band. This adjustment is attained through a DC voltage step of −0.01 V, applied within the range of 1.23–1.11 V. Additionally, the microwave equalizer is a planar structure that can be conveniently implemented on traditional printed circuit board, resulting in lower costs, easier realization, and integration. This SIW equalizer can be applied in amplitude compensation circuits and networks to compensate flatness dynamically.
Enabling the transfer matrix method to model serial–parallel compliant mechanisms including curved flexure beams
Authors: Ling Mingxiang , Yuan Lei , Zeng Tingjun , Zhang Xianmin 
Published: March 2024

AbstractCompliant mechanisms with curved flexure hinges/beams have potential advantages of small spaces, low stress levels, and flexible design parameters, which have attracted considerable attention in precision engineering, metamaterials, robotics, and so forth. However, serial–parallel configurations with curved flexure hinges/beams often lead to a complicated parametric design. Here, the transfer matrix method is enabled for analysis of both the kinetostatics and dynamics of general serial–parallel compliant mechanisms without deriving laborious formulas or combining other modeling methods. Consequently, serial–parallel compliant mechanisms with curved flexure hinges/beams can be modeled in a straightforward manner based on a single transfer matrix of Timoshenko straight beams using a step‐by‐step procedure. Theoretical and numerical validations on two customized XY nanopositioners comprised of straight and corrugated flexure units confirm the concise modeling process and high prediction accuracy of the presented approach. In conclusion, the present study provides an enhanced transfer matrix modeling approach to streamline the kinetostatic and dynamic analyses of general serial–parallel compliant mechanisms and beam structures, including curved flexure hinges and irregular‐shaped rigid bodies.
A comparison of tag retention and mortality from two tagging methods for internal tag placement in Channel Catfish
Authors: Durhack Travis C. , Simpson Holly A. , Watkinson Douglas A. , Pegg Mark A. , Enders Eva C. 
Published: March 2024

Abstract

Objective
Documenting the movement of Channel Catfish Ictalurus punctatus through telemetry, where a transmitter tag is surgically implanted in the fish, can provide valuable insight into the species' spatial ecology and habitat use. However, since fish in the order Siluriformes can expel foreign objects such as tags from their body cavity, the utility of telemetry technology may be limited for Channel Catfish. This study aimed to determine (1) how quickly Channel Catfish reject tags that were surgically implanted into the body cavity, (2) if surgical implantation of transmitter tags causes mortality, and (3) what surgical method is best to minimize tag rejection and/or mortality.

Methods
Three surgical trials were conducted on Channel Catfish (n = 24) using two tag implantation methods: a nontethered method, in which the tag was freely implanted into the body cavity, and a tethered method, where the tag was attached to the pectoral girdle. Fish were observed in the lab for 30 days for trials 1 and 2 and 225 days for trial 3 following tag implantation.

Result
No complete tag rejections occurred during any of the three experimental trials. However, all five tethered fish experienced mortality during trial 3 (58–221 days postsurgery). Necropsies indicated that the tethered tagging method led to septicaemia infections and internal lacerations from the tether, which were not observed in the nontethered fish. Tags in the nontethered fish were in the process of being absorbed into the intestinal tract, which over time might have led to tag rejection.

Conclusion
While rejection is possibly the end point of the nontethered tagging method, our results suggest it is nevertheless the better tagging method for Channel Catfish given higher survival.
Free‐breathing abdominal chemical exchange saturation transfer imaging using water presaturation and respiratory gating at 3.0 T
Authors: Chen Zhensen , Liu Chuyu , Wang Yishi , Guo Rui , Chen Weibo , Wang He , Song Xiaolei 
Published: March 2024

AbstractFree‐breathing abdominal chemical exchange saturation transfer (CEST) has great potential for clinical application, but its technical implementation remains challenging. This study aimed to propose and evaluate a free‐breathing abdominal CEST sequence. The proposed sequence employed respiratory gating (ResGat) to synchronize the data acquisition with respiratory motion and performed a water presaturation module before the CEST saturation to abolish the influence of respiration‐induced repetition time variation. In vivo experiments were performed to compare different respiratory motion‐control strategies and B0 offset correction methods, and to evaluate the effectiveness and necessity of the quasi‐steady‐state (QUASS) approach for correcting the influence of the water presaturation module on CEST signal. ResGat with a target expiratory phase of 0.5 resulted in a higher structural similarity index and a lower coefficient of variation on consecutively acquired CEST S0 images than breath‐holding (BH) and respiratory triggering (all p < 0.05). B0 maps derived from the abdominal CEST dataset itself were more stable for B0 correction, compared with the separately acquired B0 maps by a dual‐echo time scan and B0 maps derived from the water saturation shift referencing approach. Compared with BH, ResGat yielded more homogeneous magnetization transfer ratio asymmetry maps at 3.5 ppm (standard deviation: 3.96% vs. 3.19%, p = 0.036) and a lower mean squared difference between scan and rescan (27.52‱ vs. 16.82‱, p = 0.004). The QUASS approach could correct the water presaturation‐induced CEST signal change, but its necessity for in vivo scanning needs further verification. The proposed free‐breathing abdominal CEST sequence using ResGat had an acquisition efficiency of approximately four times that using BH. In conclusion, the proposed free‐breathing abdominal CEST sequence using ResGat and water presaturation has a higher acquisition efficiency and image quality than abdominal CEST using BH.
An analysis of interobserver variability in the recording of maxillary sinusitis in human osteoarchaeological remains
Authors: Davies‐Barrett Anna M. , Casna Maia , Boyd Derek A. , Inskip Sarah A. 
Published: March 2024

AbstractThe accurate comparison of prevalence rates of disease between different groups/populations is vital if we seek to contextualize our understanding of the impact of risk factors on health in the past. The majority of bioarchaeological studies of maxillary sinusitis employ the methods and “diagnostic criteria” outlined by Boocock and colleagues in 1995. However, until now, few attempts have been made to assess the inter‐rater reliability of these methods. This study presents the results of the analysis of interobserver variability in the recording of bone changes related to maxillary sinusitis among three observers within three human osteoarchaeological populations. The results of Cohen's kappa coefficient tests indicated variability in agreement between different observers. The agreement on the presence/absence of maxillary sinusitis in different osteoarchaeological populations ranged from κ = 0.433 (“moderate” agreement) to κ = 0.629 (“substantial” agreement). The agreement on the type of bone change present within affected sinuses was often poor, with almost no to negative agreement for pitting (Observers 1 and 2) and remodeled spicules (Observers 1 and 3). Methodological problems that can impact consistency of results between researchers include variability in sinus preservation, duration of observer experience, the use of different endoscopic equipment, lack of clarity in the original method descriptions, and a deficit in clinical corroborations for bone changes. The results of this study highlight the need to improve standards for the recording of bone changes related to sinusitis to allow for meaningful comparisons of past maxillary sinusitis frequency rates. Further investigations of interobserver variability, incorporating a greater range of variables, are also required.
Obstetric imaging practice characteristics associated with prenatal detection of critical congenital heart disease in a rural US region over 20 years
Authors: McLean Kelley C. , Meyer Marjorie C. , Peters Sarah R. , Wrenn Lia D. , Yeager Scott B. , Flyer Jonathan N. 
Published: March 2024

AbstractObjectiveTo identify clinical practice characteristics associated with the frequency of prenatal critical congenital heart disease (CCHD) detection (i.e., the number of liveborn infants with postnatally confirmed CCHD identified on prenatal sonography) over 20 years in a rural setting comprised of 11 primarily low‐volume obstetric hospitals and the single tertiary academic hospital to which they refer.MethodsThis was a retrospective cohort study of all patients in the referral region with an initial prenatal and/or postnatal diagnosis of CCHD from 01/01/2002 to 12/31/2021. The frequency of prenatal CCHD detection at the time of an obstetric ultrasound was reported, as was the change in detection over time. Critical congenital heart disease detection was assessed as a function of cardiac lesion type, practice setting, and practice characteristics.ResultsThere were 271 cases with a confirmed postnatal CCHD diagnosis, of which 49% were identified prenatally. The majority of community practices each averaged <10 CCHD cases in total over the study period. Prenatal detection at the tertiary academic hospital's obstetric ultrasound unit was 64%, compared to 22% at the combined referring community practices (p < 0.001), though CCHD detection improved over time in both settings. Professional accreditation by the American Institute of Ultrasound in Medicine, image interpretation by radiology or Maternal Fetal Medicine, and use of video clips of ventricular outflow tracts were associated with improved prenatal CCHD detection.ConclusionsOur data demonstrate the infrequency of CCHD cases at small‐volume, rural hospitals and the substantial variation in prenatal CCHD detection across practice settings. Our methods allowed for the identification of practice characteristics associated with prenatal CCHD detection.
Defensin‐like peptides from Capsicum chinense induce increased ROS, loss of mitochondrial functionality, and reduced growth of the fungus Colletotrichum scovillei
Authors: Resende Larissa Maximano , de Oliveira Mello Érica , Zeraik Ana Eliza , Oliveira Arielle Pinheiro Bessiati Fava , Souza Thaynã Amanda Melo , Taveira Gabriel Bonan , Moreira Felipe Figueiroa , Seabra Sérgio Henrique , Ferreira André Teixeira , Perales Jonas , de Oliveira Carvalho André , Rodrigues Rosana , Gomes Valdirene Moreira 
Published: March 2024

AbstractIn the present study, we identified and characterized two defensin‐like peptides in an antifungal fraction obtained from Capsicum chinense pepper fruits and inhibited the growth of Colletotrichum scovillei, which causes anthracnose. AMPs were extracted from the pericarp of C. chinense peppers and subjected to ion exchange, molecular exclusion, and reversed‐phase in a high‐performance liquid chromatography system. We investigated the endogenous increase in reactive oxygen species (ROS), the loss of mitochondrial functioning, and the ultrastructure of hyphae. The peptides obtained from the G3 fraction through molecular exclusion chromatography were subsequently fractionated using reverse‐phase chromatography, resulting in the isolation of fractions F1, F2, F3, F4, and F5. The F1‐Fraction suppressed C. scovillei growth by 90, 70.4, and 44% at 100, 50, and 25 μg mL−1, respectively. At 24 h, the IC50 and minimum inhibitory concentration were 21.5 μg mL−1 and 200 μg mL−1, respectively. We found an increase in ROS, which may have resulted in an oxidative burst, loss of mitochondrial functioning, and cytoplasm retraction, as well as an increase in autophagic vacuoles. MS/MS analysis of the F1‐Fraction indicated the presence of two defensin‐like proteins, and we were able to identify the expression of three defensin sequences in our C. chinense fruit extract. The F1‐Fraction was also found to inhibit the activity of insect α‐amylases. In summary, the F1‐Fraction of C. chinense exhibits antifungal activity against a major pepper pathogen that causes anthracnose. These defensin‐like compounds are promising prospects for further research into antifungal and insecticide biotechnology applications. © 2024 Society of Chemical Industry.
Rice varietal resistance to the vector Sogatella furcifera hinders transmission of Southern rice black‐streaked dwarf virus
Authors: Liu Dandan , Zhong Yuqi , Li Zhengxi , Hou Maolin 
Published: March 2024

AbstractBACKGROUNDThe Southern rice black‐streaked dwarf virus (SRBSDV) transmitted by Sogatella furcifera constitutes a threat to sustainable rice production. However, most rice varieties are highly vulnerable to SRBSDV, whereas the occurrence of the viral disease varies significantly under field conditions. This study aimed to evaluate the potential of rice varietal resistance to S. furcifera in reducing SRBSDV transmission.RESULTSAmong the five rice varieties, Zhongzheyou8 and Deyou108 exhibited high resistance to S. furcifera, Baixiangnuo33 was susceptible, and TN1 and Diantun502 were highly susceptible. The S. furcifera generally showed non‐preference for and low feeding on the Zhongzheyou8 and Deyou108 plants, which may explain the resistance of these varieties to S. furcifera. Transmission of SRBSDV by S. furcifera was significantly impaired on the resistant varieties, both inoculation and acquisition rates were much lower on Zhongzheyou8 than on TN1. The short durations of S. furcifera salivation and phloem‐related activities and the low S. furcifera feeding amount may explain the reduced SRBSDV inoculation and acquisition rates associated with Zhongzheyou8. Spearman's rank correlation revealed a significant negative correlation between S. furcifera resistance and SRBSDV transmission among the tested varieties.CONCLUSIONThe results indicate that rice varietal resistance to the vector S. furcifera hinders SRBSDV transmission, which is largely associated with the host plant selection and feeding behaviors of the vector. The current findings shed light on the management of the SRBSDV viral disease through incorporation of S. furcifera resistant rice varieties in the management protocol. © 2024 Society of Chemical Industry.
The Virtual Screening of Compounds from the ZINC Database against PARP‐1 in Triple‐Negative Breast Cancer
Authors: Priyankha Sridhar , Polk Shahrazad , Thilagavathi Ramasamy , Prakash Muthuramalingam , Kathiravan M. K. , Lakshmana Prabhu Sakthivel , Brunozi de Oliveira Isabela , Selvam Chelliah 
Published: March 2024

AbstractTriple‐negative breast cancer (TNBC) is the most aggressive kind of breast cancer that has disseminated worldwide, decimating millions of people. Especially, since it is capable of forming complex mutations, the design and development of effective drugs are much needed. Clinically, though talazoparib is an FDA‐approved drug for PARP against advanced breast cancer, it has several adverse side effects such as anaemia, alopecia, neutropenia and thrombocytopenia. Herein, to understand the molecular interactions and mode of binding, 4.59 million lead‐like compounds from the ZINC database were virtually screened against poly(ADP‐ribose) polymerase‐1 (PARP‐1) protein using molecular docking. ADMET analysis were also performed for these compounds. Molecular dynamics (MD) simulations were conducted for a period of 100 ns for the best five compounds to validate the stability of the complexes. Root‐mean‐square deviation (RMSD), root‐mean‐square fluctuation (RMSF), and the radius of gyration (Rg) were analyzed and the number of hydrogen bonding interactions was identified to determine the structure and stability of these protein‐ligand complexes. Further, binding free energy calculations were performed using the molecular mechanics‐Poisson‐Boltzmann surface area (MM/PBSA) approach to identify the effective anticancer agents. Z02, Z03, and Z04 have the highest binding affinity of −19.6, −18.1, and −18.1 kcal/mol, respectively, with PARP‐1. They also have been found to strongly enhance the stability of the target. All things considered; we determine that compound Z04 is the most promising hit for TNBC.