bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Follow‐up Study of Children with Neonatal Herpes Simplex Virus Infections with Particular Regard to Late Nervous Disturbances
Authors: MALM GUNILLA , FORSGREN MARIANNE , AZAZI MILDRED el , PERSSON ANDERS 
Published: January 2008

ABSTRACTForty‐five children with neonatal herpes simplex virus (HSV) infection, representing all known cases in the diagnostic records of four virological laboratories within a 15‐year period, were followed up. Twelve children had died. Sixteen of the 33 survivors were healthy. Thirteen children had severe disabilities: all of them showed severe mental retardation; moreover, 11 were tetraplegic, one was hemiplegic with hydrocephalus and one had a pronounced behavioural abnormality. Four children had slight to moderate disabilities: one child was mildly mentally retarded and three, although mentally normal, had hemiplegia and delayed speech development, one of them having a learning disorder as well. Of these 17 neurologically impaired children 16 had ophthalmological abnormalities. EEG recordings were made in 29 patients in the neonatal period. They were markedly abnormal in 24 patients, 14 of whom had localized periodic complexes. An abnormal EEG was a bad prognostic sign. The neurological outcome was better in the HSV‐l‐infected children (10 cases) than in the HSV‐2‐infected ones (35 cases). Progressive or recurrent encephalitis was strongly suspected in two preterm children.
Erythropoiesis of very low‐birth‐weight infants dependent on prenatal growth rate and protein status
Authors: Kivivuori SM , Järvenpää AL , Salmenperä L , Viinikka L , Siimes MA 
Published: January 2008

Kivivuori SM, Järvenpää AL, Salmenperä L, Viinikka L, Siimes MA. Erythropoiesis of very low‐birth‐weight infants dependent on prenatal growth rate and protein status. Acta Paediatr 1994; 83:13–18. Stockholm. ISSN 0803–5253This study investigated erythropoiesis in very low‐birth‐weight infants with special reference to the role of protein status in the regulation of erythropoiesis in 22 appropriate‐ and 11 small‐for‐gestational‐age infants. Blood sampies were drawn at three and six weeks of age. The serum concentrations of erythropoietin, estimated by a solid‐phase enzyme immunoassay, were similar in the two groups at both study ages. The total circulating erythrocyte volume and the serum concentration of prealbumin were higher in the appropriate‐ than in the small‐for‐gestational‐age infants at three and six weeks of age. The former group had a better protein status, although their protein intake was similar or lower. We conclude that erythropoiesis in very low‐birth‐weight infants is influenced more by protein status and prenatal growth than by serum concentration of erythropoietin.
An epidemiological study of Hirschsprung's disease and additional anomalies
Authors: Russell Michael Bjørn , Russell Charlotte Astrid , Niebuhr Erik 
Published: January 2008

Russell MB, Russell CA, Niebuhr E. An epidemiological study of Hirschsprung's disease and additional anomalies. Acta Pædiatr 1994;83:68–71. Stockholm. ISSN 0803–5253.The incidence of Hirschsprung's disease was studied in approximately 1.5 million consecutive live births in Denmark by hospital records. A diagnosis of Hirschsprung's disease required a histologic verified absence of ganglion cells in either biopsy or surgical colonic specimens. The incidence of Hirschsprung's disease was found to be 0.140 per 1000 live births (1:7,165) with a male: female ratio of 4.1:1 in short segment, and 2.4:1 in long segment Hirschsprung's disease (p = 0.36). Maternal age and birth order were unimportant factors. The association of Hirschsprung's disease and Down's syndrome was seen in 9 of the 207 patients and may represent a real association, whereas the association with congenital heart defects seen in 2% (not including patients with Down's syndrome) is more doubtful. A mortality of 16% among the patients with Hirschsprung's disease emphasizes the extreme importance of early diagnosis.
Diabetes mellitus in Danish cystic fibrosis patients: prevalence and late diabetic complications
Authors: Lanng S , Thorsteinsson B , Lund‐Andersen C , Nerup J , Schiøtz PO , Koch C 
Published: January 2008

Lanng S, Thorsteinsson B, Lund‐Andersen C, Nerup J, Schiatz PO, Koch C. Diabetes mellitus in Danish cystic fibrosis patients: prevalence and late diabetic complications. Acta Pzdiatr 1994;83: 72–7. Stockholm. ISSN 0803–5253.The prevalences of impaired glucose tolerance (IGT), diabetes mellitus and late diabetic complications were studied in all Danish cystic fibrosis (CF) patients. A total of 311 CF patients were identified with an estimated ascertainment rate above 98%. Glucose tolerdnce was classified in 278 (89%) patients: the prevalences of IGT and diabetes mellitus were 13.7% (38 patients) and 14.7% (41 patients), respectively, with no sex differences. The prevalence of diabetes mellitus increased with age but not with the severity of CF as compared with age‐ and sex‐matched non‐diabetic CF patients. Diabetes was diagnosed at a median age of 20 years (range 3–40 years) and the duration of diabetes was 1.7 years (0.1–17 years). Twenty‐eight of the diabetic patients (70%) were trcated with insulin, on average 20 (4–90) IU per day. Late diabetic complications were identified in 4 patients (10%) with a duration of diabetes mellitus of 1–17 years: background retinopathy (2 patients), diabetic nephropathy (1 patient), microalbuminuria (1 patient) and neuropathy (2 patients). Thus diabetic CF patients are probably not less prone to develop late diabetic complications than patients with other types of diabetes of equally long duration and comparable glycemic control.
Inhibitor to factor V after exposure to fibrin sealant during cardiac surgery in a two‐year‐old child
Authors: Muntean W , Zenz W , Finding K , Zobel G , Beitzke A 
Published: January 2008

Muntean W, Zenz W, Finding K, Zobel G, Beitzke A. Inhibitor to factor V after exposure to fibrin sealant during cardiac surgery in a two‐year‐old child. Acta Prediatr 1994;83:84–7. Stockholm. ISSN 0803–5253A two‐year‐old infant developed an inhibitor to factor V after cardiac surgery, with application of fibrin sealant containing bovine thrombin. Investigation of this inhibitor by means of inhibition experiments and immunoblot analysis revealed that the inhibitor reacted strongly with bovine, but only weakly with human factor V. Plasmapheresis proved effective in increasing factor V levels. This patient provides further evidence that exposure to topical thrombin preparations may lead to the development of inhibitors in the postoperative period that may cause bleeding complications.
Renal excretion of endothelin in children is influenced by age and diuresis
Authors: Mattyus Istvan , Zimmerhackl LB , Schwarz A , Hentschel M , Brandis M , Miltenyi M , Tulassay T 
Published: January 2008

Mattyus I, Zimmerhackl LB, Schwarz A, Hentschel M, Brandis M, Miltenyi M, Tulassay T. Renal excretion of endothelin in children is influenced by age and diuresis. Acta Pædiatr 1994;83:468–72. Stockholm. ISSN 0803–5253Endothelin is a peptide with vasoactive and diuretic potential. Its release has been demonstrated from endothelial and renal epithelial cells. Urinary excretion of endothelin, as shown by others, is thought to reflect intrarenal production. We measured endothelin by RIA in a population of healthy children from Germany and Hungary (group 1), neonates (group 3) and children before and during forced diuresis (groups 2a and 2b). Group 1 consisted of 24 children living in Germany and 13 children resident in Hungary. The age range in this group was 2.9–17 years. Daily excretion correlated significantly with age (r= 0.48, p < 0.001), but endothelin excretion corrected for body surface area remained constant with regard to the age group studied. This indicates that body or kidney size may influence endothelin excretion, respectively. There was no difference in endothelin excretion between the two countries. In premature infants and neonates (group 3), daily excretion of endothelin was highest in infants with very low gestational ages and decreased in full‐term neonates to values not significantly different to the group of older children. The high values in premature infants may have been influenced by mechanical ventilation of physical stress, which cannot be differentiated in this study, however. In contrast to reported results in adults, renal excretion of endothelin was correlated positively to urine flow in all groups. Furthermore, the influence of forced diuresis was evaluated in 10 children with oncological disease before (group 2a) and during (group 2b) forced diuresis with fluid load (3 l/m2; n= 4) and fluid load with furosemide injection (0.3–1.0 mg/kg body weight; n= 6). During this diuretic state, endothelin excretion was enhanced significantly.
Spectral analysis of heart rate variability in spontaneously breathing very preterm infants
Authors: van Ravenswaaij‐Arts C , Hopman J , Kollée L , Stoelinga G , van Geijn H 
Published: January 2008

Van Ravenswaaij‐Arts C, Hopman J, Kollée L, Sloelinga G, Van Geijn H. Spectral analysis of heart rate variability in spontaneously breathing very preterm infants. Acta Pædiatr 1994;83:473–80. Stockholm. ISSN 0803–5253The influence of maturation, sleep state and respiration on heart rate variability was studied in 16 spontaneously breathing preterm infants (<33 weeks). ECG, respiratory impedance curve and movements were recorded four times a day, during the first three days of life. The power content of selected frequency bands of the R‐R interval power spectrum, as well as respiratory frequency and breath amplitude oscillation frequency, were calculated for 3–min periods. An increase in low‐frequency heart rate variability with gestational age was found. High‐frequency variability increased during early postnatal life. Sleep state influenced very low‐frequency heart rate variability. The amount of respiratory sinus arrhythmia and breath amplitude sinus arrhythmia was determined mainly by respiratory rate and breath amplitude oscillation frequency, respectively. The influences of gestational and postnatal age on heart rate variability might be due to an increase in sympathetic tone before birth and a change in parasympathetic‐sympathetic balance after birth. Respiration has an important influence on heart rate variability, even in very preterm infants.
Retinopathy of prematurity: review of a seven‐year period in a Danish neonatal intensive care unit
Authors: Arrøe Mette , Peitersen Birgit 
Published: January 2008

Arrae M, Peitersen B. Retinopathy of prematurity: review of a seven‐year period in a Danish neonatal intensive care unit. Acta Pædiatr 1994;83:501–5. Stockholm. ISSN 0803–5253In the period 1985–1991, 21675 infants were born at the University Hospital of Copenhagen, Hvidovre Hospital, Denmark. Two hundred and twenty‐four infants (10.3%) with birth weights 1500 g and gestational ages 32 completed weeks were transferred to the neonatal intensive care unit of the hospital. One hundred and eighty survived to at least 8 weeks of age and 170 had eye examinations. Forty‐five of the 170 infants examined (26.5%) had retinopathy of prematurity (ROP) and 18 (40%) of these developed blindness or severely impaired vision, a higher incidence than reported in other studies. Significant differences were found between infants with and without ROP for: birth weight, gestational age, Apgar score at 1 min, resuscitation, ventilator treatment, duration of supplementary oxygen, severe complications in the neonatal period and sequels from the central nervous system. Statistical analyses, corrected for correlations, showed that the occurrence of ROP was related significantly to early intubation, hypotension, persistent ductus arteriosus and necrotizing enterocolitis.
Spermaturia in two normal boys without other signs of puberty
Authors: Nysom Karsten , Pedersen Juri L , Jørgensen Merete , Nielsen Claus T , Müller Jørn , Keiding Niels , Skakkebæk Niels E 
Published: January 2008

Nysom K, Pedersen JL, Jørgensen M, Nielsen CT, Müller J, Keiding N, Skakkebæk NE. Spermaturia in two normal boys without other signs of puberty. Acta Paediatr 1994:83:520–1. Stockholm. TSSN 0803–5253We report spermaturia in two normal boys with testicular volumes of 3 ml and no other signs of puberty. This supports the hypothesis that spermatogenesis can begin before any other signs of puberty and indicates that the definition of start of puberty as testicular volumes of 4 ml or more may be too rigorous.
Selenium in German infants fed breast milk or different formulas
Authors: Jochum F , Fuchs A , Menzel H , Lombeck I 
Published: January 2008

At birth and at 4 months of age, selenium (Se) values of 129 term infants on three different diets were determined: 50 infants were breast fed (HM), 44 received formula based on cow's milk (F) and 35 were fed “hypoallergenic formula” (PHF) (partially hydrolysed whey protein). The Se status of a group of twins (n = 12) fed “hypoallergenic formula” was compared with the respective group of singletons. All infants had low plasma Se values during early infancy. The plasma Se of breast‐fed infants remained stable (plasma Se 438 ng/ml at birth and at 4 months), whereas plasma glutathione peroxidase (GSH‐Px) decreased (birth: 10729 U/l; 4 months: 6211 U/l). The formula‐fed infants showed a reduction in plasma Se levels from birth to 4 months (3810 ng/ml and 299 ng/ml, respectively). The decrease was even more pronounced in infants fed the “hypoallergenic formula”. This group presented the lowest Se values (plasma Se 399 ng/ml at birth; 206 ng/ml at 4 months). Renal excretion of Se was found to be lower in the formula‐fed infants (F and PHF) compared with the HM group. There was a significant correlation between plasma and urinary Se (r = 0.62, p = 0.0001). Urinary Se ($uMg Se/g creatinine) appeared to be a good indicator of Se intake. Measurements of urine Se might be used as a screening method for the estimation of the Se supply. Weight and length increases in all infants were within the normal range. There were no differences between the different feeding groups.Glutathione peroxidase activity, human milk, infant formula, infant nutrition, screening method, selenium, selenium excretion, trace elements, twins F Jochum, Department of Paediatrics, Heinrich‐Heine‐University, D‐40225 Dusseldorf, Moorenstrafie 5a, Geb 23.12.02, Germany
Prognostic factors in childhood bacterial meningitis
Authors: Kaaresen PI , Flaegstad T 
Published: January 2008

The purpose of this study was to identify possible risk factors associated with a poor prognosis in childhood bacterial meningitis. We also analysed the influence of duration of symptoms and prehospital antibiotic therapy on outcome. Ninety‐two children aged 1 month to 13.8 years were included, of whom 4 died (4.3%) and 14 (15.2%) experienced permanent neurological sequelae. Hearing impairment was the most frequent sequela and was strongly associated with the length of history. Multiple logistic regression revealed duration of symptoms > 48 h, pre‐hospital seizures, peripheral vasoconstriction, < 1000 ± 106/1 leucocytes in cerebrospinal fluid and temperature38.0oC on admission as risk factors independently associated with later death or sequelae. There was no association between pre‐hospital oral or parenteral antibiotic therapy and outcome. These risk factors may be of value in selecting patients for more intensive therapy and in identifying possible candidates for new treatment strategies.Bacterial meningitis, childhood, multivariate analysis, outcome PI Kaaresen, Department of Paediatrics, University Hospital, N‐9038 RiTo, Norway
Intermittent treatment with inhaled steroids for deterioration of asthma due to upper respiratory tract infections
Authors: Scedmyr J , Nyberg E , Åsbrink‐Nilsson E , Hedlin  
Published: January 2008

Upper respiratory tract infection (URTI) is a common cause of deterioration of asthma in children. We investigated if inhaled steroids (budesonide), started early after URTI, could reduce asthma. Thirty‐one children, 3‐10 years of age, with deterioration during URTI participated. The study design was double‐blind, crossover and placebo‐controlled. Peak‐expiratory flow (PEF) and symptom scores were recorded. Four treatment periods of 9 days, two with budesonide and two with placebo, were planned. Treatment was started at the first sign of URTI. Budesonide/placebo was given by Turbuhaler at 0.2 mg qid for 3 days, tid for 3 and bid for the last 3 days. Twenty‐two children completed 67 periods. Eleven visited the emergency room, only three during budesonide therapy. Five received oral steroids and two where admitted to hospital, all receiving placebo. Symptom scores were not significantly lower during budesonide treatment. PEF, both morning and evening, was significantly higher during budesonide than placebo (p= 0.015 and p = 0.022). Inhaled budesonide can attenuate exacerbation of URTI‐induced asthma.Asthma, budesonide, infection, inhaled steroids, intermittent, prophylactic J Svedmyr, Department of Paediatrics, Falu Hospital, S‐791 82 Falun, Sweden
Early growth is not increased in untreated moderately severe 21‐hydroxylase deficiency
Authors: Thilén A , Woods KA , Perry LA , Savage MO , Wedell A , Ritzén EM 
Published: January 2008

The pretreatment growth of 1 British and 14 Swedish children with late (2‐7 years) diagnosis of 21‐hydroxylase deficiency (210HD) was studied. The latter group included all patients diagnosed in Sweden after 1986. Twelve had mutations of the 21‐hydroxylase gene that are generally associated with moderately severe (“simple virilizing”) forms of 210HD, one had a severe (“salt‐losing”) and one a mild (“non‐classical”) form. The British girl was followed from 4 months of age. She had grossly elevated levels of 17a‐hydroxyprogesterone, androstenedione and testosterone in blood, but her parents refused treatment until she was 4 years of age. None of the 15 children showed any significant increase in growth or progress of virilization until after 18 months of age. These observations indicate that growth during the first 1.5 years is not very sensitive to androgens. Thus glucocorticoid replacement during the first year of life should be kept to a minimum to avoid over‐treatment.Congenital adrenal hyperplasia, CYP21, genotype, growth, infancy EM Ritzen, Pediatric Endocrinology Unit, Karolinska Hospital, S‐171 76 Stockholm, Sweden
Low levels of plasminogen in cerebrospinal fluid after intraventricular haemorrhage: a limiting factor for clot lysis?
Authors: Whitelaw A , Mowinckel M‐C , Abildgaard U 
Published: January 2008

The aim of this study was to measure plasminogen in the cerebrospinal fluid (CSF) of control neonates with no infection or haemorrhage and in infants who had suffered intraventricular haemorrhage (IVH). A chromogenic substrate method was used. The 16 reference infants had a median CSF plasminogen level of 0.74% of that of normal adult plasma (range 0.17‐1.1%). The 11 infants with IVH had a median CSF plasminogen level of 0.55% of normal adult plasma (range 0‐4.4%). Six of the IVH infants went on to develop permanent hydrocephalus despite the use of intraventricular plasminogen activators. Endogenous fibrinolysis and the potential for fibrinolytic treatment in the CSF may be limited by low concentrations of plasminogen, and administration of recombinant plasminogen may assist attempts to clear intraventricular blood clots.Cerebrospinal fluid, hydrocephalus, intraventricular haemorrhage, newborn infant, plasminogen A Whitelaw, Department of Paediatrics, Aker University Hospital, 0514 Oslo, Norway
Combined treatment with enuresis alarm and desmopressin for nocturnal enuresis
Authors: Bradbury MG , Meadow SR 
Published: January 2008

Seventy‐one children with nocturnal enuresis were enrolled in a controlled trial. The children were allocated to two matched groups. Children in both groups used an enuresis alarm until the end of treatment. Children in the first group were treated with 40/^g of intranasal desmopressin (Desmospray) for up to 6 weeks at the start of treatment with the alarm. During the observation period before treatment there were 2.3 dry nights per week in both groups. At the end of treatment there was a significant difference in the mean number of dry nights per week between the two groups (6.3 in the alarm and desmopressin group and 4.8 in the alarm group) and also in the number of children becoming reliably dry. The combination of desmopressin and alarm was particularly helpful for children with severe wetting and those with family and behavioural problems.Desmopressin, enuresis alarm, nocturnal enuresis MG Bradbury, Department of Paediatrics and Child Health, St James's University Hospital, Leeds LS9 7TF, UK
Empowerment/Sexism: Figuring Female Sexual Agency in Contemporary Advertising
Authors: Gill Rosalind 
Published: January 2008

This article argues that there has been a significant shift in advertising representations of women in recent years, such that rather than being presented as passive objects of the male gaze, young women in adverts are now frequently depicted as active, independent and sexually powerful. This analysis examines contemporary constructions of female sexual agency in advertisements examining three recognizable `figures': the young, heterosexually desiring `midriff', the vengeful woman set on punishing her partner or ex-partner for his transgressions, and the `hot lesbian', almost always entwined with her beautiful Other or double. Using recent examples of adverts, the article asks how this apparent `agency' and `empowerment' should be understood. Drawing on accounts of the incorporation or recuperation of feminist ideas in advertising, the article takes a critical approach to these representations, examining their exclusions, their constructions of gender relations and heteronormativity, and the way power is figured within them. A feminist poststructuralist approach is used to interrogate the way in which `sexual agency' becomes a form of regulation in these adverts that requires the re-moulding of feminine subjectivity to fit the current postfeminist, neoliberal moment in which young women should not only be beautiful but sexy, sexually knowledgeable/practised and always `up for it'. The article makes an original contribution to debates about representations of gender in advertising, to poststructuralist analyses about the contemporary operation of power, and to writing about female `sexual agency' by suggesting that `voice' or `agency' may not be the solution to the `missing discourse of female desire' but may in fact be a technology of discipline and regulation.
Adsorption of Textile Dyes Using Agave Americana (L.) Fibres: Equilibrium and Kinetics Modelling
Authors: Hamissa Aïcha Menyar Ben , Brouers François , Mahjoub Borhane , Seffen Mongi 
Published: January 2008

This study was carried out to examine the potential of Agave americana fibres (AAF) for the treatment of wastewater contaminated with dyes. The batch mode adsorption of two dyes, viz. Sumfixe Supra Red (SSR) and Alpacelle Lumiere Brown (ALB), by AAF was investigated at different pH values, temperatures and initial dye concentrations. The highest dye adsorption capacities at 30°C were attained at pH 2.0 for SSR and at pH 2.5 for ALB. In both cases, an increase in temperature increased the velocity of the reaction. The maximum amounts of dyes desorbed were at basic pH values. To compare our results with studies on other biomaterials, the adsorption isotherms and kinetic data were analysed employing the usual models (Freundlich, Langmuir and Temkin isotherms and first- and second-order kinetics). Conventional analysis indicated that the kinetics of the processes were closer to pseudo-second order rather than first order. The data were also modelled with a new method of analysis based on the statistical theory of complex systems and the heterogeneity of the sorption energy (energy landscape). This enabled the adsorption process to be characterised in terms of a greater number of physical parameters.