bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Teori Legitimasi Pada Konflik Rekognisi Penguasaan Tanah Adat antara PT Asam Jawa dengan Komunitas Terdampak
Authors: Hayati Harahap Rahma Hayati Harahap , Nahwa Zainab Marpaung  
Published: March 2024

Agrarian conflicts in the plantation sector are dominated by oil palm plantation conflicts. This article discusses the conflict over recognition of customary land tenure that occurred in Torgamba District involving PT Asam Jawa and affected communities. The theory used to analyze the conflict of recognition of customary land tenure is the theory of legitimacy. The method used is the study of literature and literature. Data collection techniques are carried out through scientific journals and other literature sources related to studies and research problems. The results showed that there was a legitimacy gap that occurred between PT Asam Jawa and the affected communities. The legitimacy gap is caused by PT Asam Jawa's failure to meet the needs and expectations of the community and comply with norms, values, and boundaries recognized by local residents.
Trust and Social Capital of Patients in Engkong Traditional Medicine in Binjai City
Authors: Riris Indriani Riris 
Published: March 2024

Health is the most important indicator for every human, when a person is declared healthy, all his activities will run well. If you look at health services in Indonesia, it shows there is a combination of modern medicine and traditional medicine. This research was conducted to interpret how social capital as a traditional treatment strategy engkong with the actions of people who choose decisions in curing diseases. On the other hand, it is also to describe that there is no coercion of a person to practice traditional medicine. The method used descriptive qualitative approach. Data collection techniques are carried out by observation, in-depth interviews and relevant literature studies. The results of the study can be concluded the contribution of trust and social capital to patients is useful in traditional medicine and can also maintain the existence of traditional medicine. With the social capital in traditional engkong medicine in Binjai City, it will make it very easier for the surrounding community to carry out traditional healing, with the therapeutic kusuk technique carried out by Engkong doesn’t produce side effects in the future. The most powerful social capital influence is the existence of networks and beliefs while those with weak influences are social values and norms.
Tracking Investment Intentions: The Impact of Information, Confusion, and Avoidance Attitude in Stock Investment Applications
Authors: Hutauruk Bie Amelia , Atmaja Ferry Tema 
Published: March 2024

<p><strong>Abstract – </strong>The proliferation of stock investment applications has significantly augmented the accessibility and speed of acquiring investment-related information. However, the ease of information access may inadvertently lead to information overload, fostering confusion and, in extreme cases, user avoidance of these applications. Despite the potential ramifications of overload information on avoidance behaviors, research linking consumer confusion to avoidance attitudes and intentions remains scarce. This study seeks to bridge this gap by identifying factors influencing individuals' intentions to avoid using stock investment applications, specifically focusing on information acquisition, overload confusion, and avoidance attitudes. Conducted through online questionnaires, data collection involved 130 responses that met the specified criteria, subsequently analyzed using SmartPLS 3 software. The findings reveal that effective information acquisition diminishes avoidance attitudes and intentions but does not impact overload confusion. Furthermore, overload confusion escalates avoidance attitudes without influencing intention to avoid. Notably, avoidance attitudes exhibit a positive correlation with the intention to avoid using stock investment applications. This research contributes to the academic landscape by shedding light on the underexplored role of overload confusion in shaping avoidance behaviors, offering insights not extensively addressed in prior studies. Moreover, it provides valuable implications for practitioners in the financial industry, offering guidance for the development of more effective marketing strategies in the context of stock investment applications.<strong></strong></p><p><strong> </strong></p><p>Keywords: intention to avoid, information acquisition, overload confusion, avoidance attitude</p>
Strategi pengembangan karir melalui pelatihan soft skill
Authors: Widiawati Prisca , Yunus Moch. , Hanief Yulingga Nanda , Erdilanita Ulma , Purwadi Dinda Arisetya 
Published: March 2024

Soft skill memainkan peran penting dalam karir dan interaksi sosial di masyarakat. Data tracer yang diperoleh melalui (Universitas Negeri Malang, 2021) memaparkan bahwa, 58,42% lulusan program studi pendidikan kepelatihan olahraga (PKO) menunggu untuk mendapatkan pekerjaan rata-rata 3 bulan. Hal tersebut sebagai landasan pelatihan soft skill guna bekal alumni dalam bekerja dan kehidupan sehari-hari untuk meniti karir. Dengan diadakannya pelatihan personal branding for career development akan menambah wawasan dan keterampilan alumni, sehingga diharapkan dapat memberikan bekal para pelatih khususnya alumni PKO agar lebih siap bersaing didunia kerja. Kegiatan pengabdian ini menggunakan metode Participatory Action Research (PAR). Data primer didapatkan melalui pre-test kepada alumni PKO sebelum pelatihan dan setelah pelatihan diberikan post-test menggunakan platform Quizizz sebagai alat bantu. Adapun data sekunder yang diperoleh melalui pengamatan secara langsung selama kegiatan. Hasil dari kegiatan pengabdian ini yaitu tercapainya keberhasilan target alumni PKO yaitu 30 peserta, ketercapaian tujuan pelatihan yaitu memberikan peningkatan pengetahuan dan pemahaman alumni sebesar 25,44% dari yang awalnya (pre-test) 45.16% menjadi 70,6% (post-test), ketercapaian target materi yang telah direncanakan yaitu 12 materi terkait soft skill dalam olahraga, pemahaman alumni dalam menerima materi yang disampaikan dibuktikan melalui hasil post-test peserta. Hal ini menunjukkan adanya peningkatan pengetahuan pada alumni setelah dilaksanakannya pelatihan hybrid soft skill dan diberikan produk berupa video materi soft skill. Video tersebut dapat dipelajari kembali sebagai bekali diri untuk bersaing di dunia kerja.
Tremor in cervical dystonia
Authors: Beylergil Sinem Balta , Mukunda Krishna Nikhil , Elkasaby Mohamed , Perlmutter Joel S. , Factor Stewart , Bäumer Tobias , Feurestein Jeanne , Shelton Erika , Bellows Steven , Jankovic Joseph , Mahajan Abhimanyu , Wamer-Rosen Tila , Reich Stephen G. , Wagle Shukla Aparna , Malaty Irene , Espay Alberto , Duque Kevin , LeDoux Mark S. , Saunders-Pullman Rachel , Leaver Katherine , Frank Samuel , Pantelyat Alexander , Fung Victor , Pirio Richardson Sarah , Berman Brian , Stover Natividad , Deik Andres , Ondo William , Groth Christopher , Jinnah Hyder A. , Shaikh Aasef G. 
Published: March 2024

Background: Cervical dystonia (CD) is the most common form of focal dystonia encountered in the clinic. Approximately one-third of CD patients have co-existing tremor in the head and hands. Assessment of tremor as regular or irregular in context of its oscillation trajectory, frequency, and amplitude is a major clinical challenge and can confound the diagnosis of CD. The misdiagnosis may lead to therapeutic failures, poor quality of life, and poor utilization of medical and financial resources.Methods: We analyzed the largest cohort of CD patients (n = 3117) available to date, collected from 37 movement disorder centers in North America, Europe, and Asia. We used machine learning to determine what clinical features from clinician reports predicted the presence of tremor as well as its regular or irregular appearance.Results: Out of 3,117 CD patients, 1,367 had neck tremor. The neck tremor was interpreted as irregular in 1,022, regular in 345, and mixed (both irregular and regular) in 442. A feature importance analysis determined that greater severity of CD, longer disease duration, and older age, in descending order, predicted the presence of neck tremor. The probability of neck tremor was reduced if the dystonia affected other body parts in addition to the neck. We also found a significantly heightened risk for developing neck tremor in women. An additional feature importance analysis indicated that increased severity of dystonia affecting other body parts, severity of CD, and prolonged disease duration was associated with a lower likelihood of regular neck tremor while increased age predicted a higher likelihood.Conclusion: Machine learning recognized the most relevant clinical features that can predict concurrent neck tremor and its irregularity in a large multi-center dystonia cohort. These results may facilitate a more accurate description of neck tremor and improved care path in CD.
Improving product quality and productivity of an antibody-based biotherapeutic using inverted frustoconical shaking bioreactors
Authors: Wang Xuekun , Xu Jin , Guo Qingcheng , Li Zhenhua , Cao Jiawei , Fu Rongrong , Xu Mengjiao , Zhao Xiang , Wang Fugui , Zhang Xinmeng , Dong Taimin , Li Xu , Qian Weizhu , Hou Shen , Ji Lusha , Zhang Dapeng , Guo Huaizu 
Published: March 2024

The Chinese hamster ovarian (CHO) cells serve as a common choice in biopharmaceutical production, traditionally cultivated in stirred tank bioreactors (STRs). Nevertheless, the pursuit of improved protein quality and production output for commercial purposes demand exploration into new bioreactor types. In this context, inverted frustoconical shaking bioreactors (IFSB) present unique physical properties distinct from STRs. This study aims to compare the production processes of an antibody-based biotherapeutic in both bioreactor types, to enhance production flexibility. The findings indicate that, when compared to STRs, IFSB demonstrates the capability to produce an antibody-based biotherapeutic with either comparable or enhanced bioprocess performance and product quality. IFSB reduces shear damage to cells, enhances viable cell density (VCD), and improves cell state at a 5-L scale. Consequently, this leads to increased protein expression (3.70 g/L vs 2.56 g/L) and improved protein quality, as evidenced by a reduction in acidic variants from 27.0% to 21.5%. Scaling up the culture utilizing the Froude constant and superficial gas velocity ensures stable operation, effective mixing, and gas transfer. The IFSB maintains a high VCD and cell viability at both 50-L and 500-L scales. Product expression levels range from 3.0 to 3.6 g/L, accompanied by an improved acidic variants attribute of 20.6%–22.7%. The IFSB exhibits superior productivity and product quality, underscoring its potential for incorporation into the manufacturing process for antibody-based biotherapeutics. These results establish the foundation for IFSB to become a viable option in producing antibody-based biotherapeutics for clinical and manufacturing applications.
Dopamine promotes Klebsiella quasivariicola proliferation and inflammatory response in the presence of macrophages
Authors: Li Xiang , Cheng Lin , Liu Xueyang , Wang Xiaoli , Li Rui , Fan Shao , Yan Qiulong , Ma Tonghui , Ma Yufang , Kang Jian 
Published: March 2024

BackgroundDopamine, a frequently used therapeutic agent for critically ill patients, has been shown to be implicated in clinical infections recently, however, the precise mechanisms underlying this association remain elusive. Klebsiella quasivariicola, a novel strain belonging to the Klebsiella species, exhibits potential pathogenic attributes. The impact of dopamine on K. quasivariicola infection has aroused our interest.ObjectiveConsidering the contribution of host immune factors during infection, this study aimed to investigate the intricate interactions between K. quasivariicola, dopamine, and macrophages were explored.MethodsRAW264.7 cells and C57/BL6 mice were infected with K. quasivariicola, and the bacterial growth within macrophage, the production of inflammatory cytokines and the pathological changes in mice lungs were detected, in the absence or presence of dopamine. ResultsDopamine inhibited the growth of K. quasivariicola in the medium, but promoted bacterial growth when co-cultured with macrophages. The expression of proinflammatory cytokines increased in RAW 264.7 cells infected with K. quasivariicola, and a significant rise was observed upon the addition of dopamine. The infection of K. quasivariicola in mice induced an inflammatory response and lung injury, which were exacerbated by the administration of dopamine. ConclusionsOur findings suggest that dopamine may be one of the potential risk factors associated with K. quasivariicola infection. This empirical insight provides solid references for clinical precision medicine. Furthermore, an in vitro model of microbes-drugs-host immune cells for inhibitor screening was proposed to more accurately replicate the complex in vivo environment. This fundamental work had contributed to the present understanding of the crosstalk between pathogen, dopamine and host immune cells.
Comparing the efficacy of glucocorticoids and anti-VEGF in treating diabetic macular edema: systematic review and comprehensive analysis
Authors: Cheng Zhi’ang , Liu Xiaoyong 
Published: March 2024

IntroductionThe aim of this study was to better understand the efficacy of various drugs, such as glucocorticoids and anti-vascular endothelial growth factors (VEGF), in the treatment of diabetic macular edema (DME), and to evaluate various clinical treatment regimens consisting of different therapeutic measures.MethodsThis study included randomized controlled trials up to February 2023 comparing the efficacy of corticosteroid-related therapy and anti-VEGF therapy. PubMed, the Cochrane Library, and Embase were searched, and the quality of the studies was carefully assessed. Finally, 39 studies were included.ResultsResults at 3-month followup showed that intravitreal injection of bevacizumab (IVB) + triamcinolone acetonide (TA) was the most beneficial in improving best-corrected visual acuity and reducing the thickness of macular edema in the center of the retina in patients with DME. Results at 6-month follow-up showed that intravitreal dexamethasone (DEX) was the most effective in improving patients’ bestcorrected visual acuity and reducing the thickness of central macular edema.DiscussionOverall, IVB+TA was beneficial in improving best-corrected visual acuity and reducing central macular edema thickness over a 3-month follow-up period, while DEX implants had a better therapeutic effect than anti-VEGF agents at 6 months, especially the patients with severe macular edema and visual acuity impaired.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=397100, identifier CRD42023397100.
Systemic inflammatory regulators and preeclampsia: a two-sample bidirectional Mendelian randomization study
Authors: Li Chu , Tian Yishu , Dougarem Djouhayna , Sun Litao , Zhong Zixing 
Published: March 2024

Background:Systemic inflammatory regulators have been associated with preeclampsia (PE) during pregnancy; however, there is inconsistent evidence from animal models and observational results.Methods:Using summary data from genome-wide association studies (GWASs), we performed a bidirectional Mendelian randomization (MR) analysis of two samples of systemic inflammatory regulators (n = 8,186) and PE (n = 267,242) individuals of European ancestry. As our primary analysis, we used the random-effects inverse-variance weighted (IVW) approach. Sensitivity and pleiotropy analyses were conducted using the MR–Egger method, weighted median, MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO), and Cochran’s Q test.Results:The results indicate that there is a correlation between a higher circulating level of tumor necrosis factor alpha (TNF-α) and interleukin-9 (IL-9) and an increased risk of PE (odds ratio [OR] = 1.32, 95% confidence interval [CI] = 1.09–1.60, p = 0.004 and OR = 1.28, 95% CI: 1.02–1.62, p = 0.033, respectively). Conversely, lower levels of stem cell growth factor beta (SCGF-β) (OR = 0.89, 95% CI: 0.80–0.99, p = 0.027) and interleukin-5 (IL-5) (OR = 0.80, 95% CI: 0.65–0.98, p = 0.030) are linked to an increased risk of PE. The macrophage migration inhibitory factor (MIF) is the downstream inflammatory regulator of PE, according to reverse magnetic resonance imaging studies.Conclusion:Our study suggests that SCGF-β, IL-5, IL-9, and TNF-α causally affect the PE risk, while PE is causally associated with MIF. Further studies are needed to validate these biomarkers in managing PE.
The immunomodulatory impact of naturally derived neem leaf glycoprotein on the initiation progression model of 4NQO induced murine oral carcinogenesis: a preclinical study
Authors: Das Juhina , Bera Saurav , Ganguly Nilanjan , Guha Ipsita , Ghosh Halder Tithi , Bhuniya Avishek , Nandi Partha , Chakravarti Mohona , Dhar Sukanya , Sarkar Anirban , Das Tapasi , Banerjee Saptak , Ghose Sandip , Bose Anamika , Baral Rathindranath 
Published: March 2024

IntroductionMurine tumor growth restriction by neem leaf glycoprotein (NLGP) was established in various transplanted models of murine sarcoma, melanoma and carcinoma. However, the role of NLGP in the sequential carcinogenic steps has not been explored. Thus, tongue carcinogenesis in Swiss mice was induced by 4-nitroquinoline-1-oxide (4NQO), which has close resemblance to human carcinogenesis process. Interventional role of NLGP in initiation-promotion protocol established during 4NQO mediated tongue carcinogenesis in relation to systemic immune alteration and epithelial-mesenchymal transition (EMT) is investigated.Methods4NQO was painted on tongue of Swiss mice every third day at a dose of 25µl of 5mg/ml stock solution. After three consecutive treatments with 4NQO (starting Day7), one group of mice was treated with NLGP (s.c. 25μg/mice/week), keeping a group as PBS control. Mice were sacrificed in different time-intervals to harvest tongues and studied using histology, immunohistochemistry, flow-cytometry and RT-PCR on different immune cells and EMT markers (e-cadherin, vimentin) to elucidate their phenotypic and secretory status.ResultsLocal administration of 4NQO for consecutive 300 days promotes significant alteration in tongue mucosa including erosion in papillae and migration of malignant epithelial cells to the underlying connective tissue stroma with the formation of cell nests (exophytic-hyperkeratosis with mild dysplasia). Therapeutic NLGP treatment delayed pre-neoplastic changes promoting normalization of mucosa by maintaining normal structure. Flow-cytometric evidences suggest that NLGP treatment upregulated CD8+, IFNγ+, granzyme B+, CD11c+ cells in comparison to 4NQO treated mice with a decrease in Ki67+ and CD4+FoxP3+ cells in NLGP treated cohort. RT-PCR demonstrated a marked reduction of MMP9, IL-6, IL-2, CD31 and an upregulation in CCR5 in tongues from 4NQO+NLGP treated mice in comparison to 4NQO treated group. Moreover, 4NQO mediated changes were associated with reduction of e-cadherin and simultaneous up-regulation of vimentin expression in epithelium that was partially reversed by NLGP.DiscussionEfficacy of NLGP was tested first time in sequential carcinogenesis model and proved effective in delaying the initial progression. NLGP normalizes type 1 immunity including activation of the CD8+T effector functions, reduction of regulatory T cell functions, along with changes in EMT to make the host systemically alert to combat the carcinogenic threat.
Accuracy of an artificial intelligence as a medical device as part of a UK-based skin cancer teledermatology service
Authors: Marsden Helen , Kemos Polychronis , Venzi Marcello , Noy Mariana , Maheswaran Shameera , Francis Nicholas , Hyde Christopher , Mullarkey Daniel , Kalsi Dilraj , Thomas Lucy 
Published: March 2024

IntroductionAn artificial intelligence as a medical device (AIaMD), built on convolutional neural networks, has demonstrated high sensitivity for melanoma. To be of clinical value, it needs to safely reduce referral rates. The primary objective of this study was to demonstrate that the AIaMD had a higher rate of correctly classifying lesions that did not need to be referred for biopsy or urgent face-to-face dermatologist review, compared to teledermatology standard of care (SoC), while achieving the same sensitivity to detect malignancy. Secondary endpoints included the sensitivity, specificity, positive and negative predictive values, and number needed to biopsy to identify one case of melanoma or squamous cell carcinoma (SCC) by both the AIaMD and SoC.MethodsThis prospective, single-centre, single-arm, masked, non-inferiority, adaptive, group sequential design trial recruited patients referred to a teledermatology cancer pathway (clinicaltrials.gov NCT04123678). Additional dermoscopic images of each suspicious lesion were taken using a smartphone with a dermoscopic lens attachment. The images were assessed independently by a consultant dermatologist and the AIaMD. The outputs were compared with the final histological or clinical diagnosis.ResultsA total of 700 patients with 867 lesions were recruited, of which 622 participants with 789 lesions were included in the per-protocol (PP) population. In total, 63.3% of PP participants were female; 89.0% identified as white, and the median age was 51 (range 18–95); and all Fitzpatrick skin types were represented including 25/622 (4.0%) type IV-VI skin. A total of 67 malignant lesions were identified, including 8 diagnosed as melanoma. The AIaMD sensitivity was set at 91 and 92.5%, to match the literature-defined clinician sensitivity (91.46%) as closely as possible. In both settings, the AIaMD identified had a significantly higher rate of identifying lesions that did not need a biopsy or urgent referral compared to SoC (p-value = 0.001) with comparable sensitivity for skin cancer.DiscussionThe AIaMD identified significantly more lesions that did not need to be referred for biopsy or urgent face-to-face dermatologist review, compared to teledermatologists. This has the potential to reduce the burden of unnecessary referrals when used as part of a teledermatology service.