bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of intervenable factors to reduce vascular complications in patients with internal carotid artery occlusion treated by non-emergency endovascular treatment
Authors: Wu Guangyu , Nong Yuxin , Hong Shaorui , Wang Shuo , Dai Chengbo , He Chizhong , Li Changmao , Ma Tengyun , Yang Zhexian , Zhang Bin , Gao Yuyuan , Ma Guixian 
Published: March 2024

ObjectiveThis study aims to identify risk factors for vascular complications during non-emergency endovascular treatment in patients with internal carotid artery occlusion (ICAO) and to propose potential interventions.MethodA retrospective analysis of 92 patients with ICAO who received non-emergency endovascular treatment in our center from 1 January 2018 to 31 June 2023, was conducted. The correlation between intraoperative vascular complications and potential risk factors was studied, and interaction analysis was performed.ResultsOur findings revealed that the use of non-neurology guide wires to open vessels (adjusted OR: 4.1, 95%CI: 1.3–12.8; p = 0.014) and glycosylated hemoglobin (HbA1c) ≥ 6.5 mmol/L (adjusted OR: 3.2, 95%CI: 1.2–8.9; p = 0.023) was significantly associated with vascular complications in non-emergency endovascular treatment of ICAO patients. The restricted cubic spline (RCS) showed that the higher the HbA1c level, the higher the risk of vascular complications.ConclusionThe use of non-neurology guide wires for vessel opening during non-emergency endovascular treatment in patients with ICAO increases the risk of vascular complications. Preoperative assessment and management of HbA1c levels can reduce the incidence of intraoperative vascular complications.
Genetic alterations in myeloid sarcoma among acute myeloid leukemia patients: insights from 37 cohort studies and a meta-analysis
Authors: Untaaveesup Suvijak , Trithiphen Sasinipa , Kulchutisin Kamolchanok , Rungjirajittranon Tarinee , Leelakanok Nattawut , Panyoy Sujitra , Kaokunakorn Thanapon , Owattanapanich Weerapat 
Published: March 2024

IntroductionVariations in mutation rates among acute myeloid leukemia (AML) patients with myeloid sarcoma (MS) underscore the need for a thorough examination. This meta-analysis was conducted to fill the information gap concerning mutation frequencies in AML patients presenting with MS.Materials and methodsThis study included retrospective and prospective cohorts. It examined genetic alterations in AML patients with and without MS across all age groups. The search strategy employed terms such as “acute myeloid leukemia,” “extramedullary,” “granulocytic sarcoma,” “myeloid sarcoma,” and “leukemic cutis” in the EMBASE, MEDLINE, and Scopus databases. Excluded from the study were reviews, case reports, and case series with fewer than 10 cases. Statistical analyses were performed with Review Manager 5.4 software.ResultsThe primary analysis incorporated data from 37 cohorts involving 5646 diagnosed AML patients and revealed a 17.42% incidence of MS. The most prevalent mutation among AML patients with MS was FLT3-ITD, with a pooled prevalence of 17.50% (95% CI 12.60% to 22.50%; I2 82.48%). The dominant fusion gene was RUNX1::RUNX1T1, displaying a pooled prevalence of 28.10% (95% CI 15.10% to 41.20%; I2 96.39%). In comparison, no significant intergroup differences were observed for NPM1, FLT3-ITD, KIT, and IDH2 mutations. Interestingly, the CEBPA mutation exhibited protective effects for MS patients, with an odds ratio of 0.51 (95% CI 0.32 to 0.81; I2 0%). Conversely, the NRAS mutation was associated with an increased risk of MS development, with an odds ratio of 5.07 (95% CI 1.87 to 13.73; I2 0%).ConclusionThis meta-analysis sheds light on the prevalence of genetic mutations in AML patients with MS, providing insights into the unique characteristics of the mutations and their frequencies. These discoveries are crucial in informing therapeutic and prognostic decisions for individuals with myeloid sarcoma.
Burkitt's lymphoma in a young boy progressing to systemic lupus erythematosus during follow-up: a case report and literature review
Authors: Liu Chenxi , Pan Ci , Jin Yingying , Huang Hua , Ding Fei , Xu Xuemei , Bao Shengfang , Han Xiqiong , Jin Yanliang 
Published: March 2024

IntroductionPatients with systemic lupus erythematosus (SLE) are at a higher risk of developing cancer, particularly hematological malignancies such as lymphoma and leukemia. However, existing studies on this topic that assess cancer incidence following SLE diagnosis are limited. In addition, SLE can be diagnosed after cancer, although such cases in children have been rarely reported.Case reportWe present the case of a 2.6-year-old boy who presented to our institute with fever and abdominal pain. His physical examination revealed a periumbilical mass, which was pathologically diagnosed as Burkitt's lymphoma. Autologous stem cell transplantation was performed to consolidate the effect of chemotherapy and reduce the risk of cancer relapse. He was diagnosed with SLE 5 years later, following the presentation of a fever with rash, positive autoantibodies, decreased complement, and kidney involvement. At the final follow-up, the patient was still alive and showed no recurrence of Burkitt's lymphoma or disease activity of SLE.ConclusionDespite the low frequency of SLE in children with lymphoma, cancer and SLE may be induced by a common mechanism involving B-cell cloning and proliferation. Therefore, hematologists and rheumatologists should be aware of the occurrence of these two conditions during patient follow-up.
Optimization and preparation of a compound cod liver oil film former agent: an orthogonal design
Authors: He Yao , Zhang Ying , Li Zheng 
Published: March 2024

Background: Cod liver oil has anti-inflammatory properties and could help regulate recurrent aphthous stomatitis (RAS). An orthogonal experiment was used to evaluate and improve the dosage form of compound cod liver oil, which has replaced the previously used liniment preparation based on film method.Methods: An orthogonal experiment was adopted, and the appearance and film-forming time of the film coating agents were used as indicators. The optimal ratio in the preparation process for the compound cod liver oil film agent was then optimized. A method for determination of compound cod liver oil film was established using High-Performance Liquid Chromatography (HPLC).Results: The results indicate that the blank films prepared using 55 mg polyvinyl alcohol (PVA) (PVA low), 45 mg of PVA (PVA medium), and 10 mg glycerol had the optimal performance, which was defined as PVAa. The drug-carrying film prepared from 3 mL PVAa (i.e., film-forming material with the optimal proportion), 30 mg dexamethasone acetate, and 30 mg metronidazole had the optimal performance. The verified sample has a complete and smooth appearance, uniform thickness and color, and no evident bubbles, which meets the requirements for a film agent defined in the Chinese Pharmacopoeia, 2020 edition. HPLC was used to determine the major components: dexamethasone acetate, metronidazole, and dyclonine hydrochloride, and the optimal separation effect was obtained. The method has advantages of good specificity, good linear results, high recovery rate, and good repeatability.Conclusion: This study proposes an optimized compound cod liver oil film former agent and preparation method. The results indicate that the compound cod liver oil film former agent had good performance, reflecting the high feasibility of this research method. The detection method of compound cod liver oil film was established by HPLC. The method was feasible, and the validity and stability of the formulation and preparation technology were guaranteed. The role of the newly developed agent in patients with RAS should be investigated further.
The effects of Massa Medicata Fermentata on the digestive function and intestinal flora of mice with functional dyspepsia
Authors: Wang Shuyu , Li Yuanlin , Yang Xiaoqi , Hao Yinxue , Zhan Xueyan 
Published: March 2024

Introduction: The purpose of this study was to identify the chemical components of Massa Medicata Fermentata (MMF) in different fermentation methods, analyze its regulatory effects on gastrointestinal propulsion and intestinal flora in mice with food accumulation, and further explore its mechanism of action in the treatment of dyspepsia.Methods: The chemical compositions of three kinds of MMF were identified using the UPLC-Q- Exactive Orbitrap mass spectrometer. A model of spleen deficiency and food accumulation in mice was established. The gastric emptying rate and intestinal propulsion rate were calculated, serum gastrin concentration and cholinesterase activity were measured, and 16S rRNA microbial detection was performed in different groups of mouse feces.Results: The results showed that a total of 95 chemical components were identified from the three MMF extracts, 62 of which were the same, but there were differences in flavonoids and their glycosides, organic acids, and esters. MMF, PFMMF, and commercial MMF could all significantly improve the gastric emptying rate, intestinal propulsion rate, and GAS concentration in the serum of model mice; PFMMF has a better effect, while there was no significant difference in cholinesterase activity among the groups (p &gt; 0.05). The 16S rRNA sequencing results showed that the MMF and PFMMF could increase the content of beneficial bacteria Bacteroidetes and decrease the pathogenic bacteria Verrucomicrobia in the intestines of model mice, while the commercial MMF could not.Discussion: Studies suggest that MMF has a variety of possible mechanisms for improving food accumulation and treating gastrointestinal dyspepsia, which provides reference value for the quality evaluation and clinical application of MMF.
Transient submillimeter-scale periodic banding of Ag2O precipitate through reaction–transport–reaction processes
Authors: Hayashi Hisashi , Yamada Kaho 
Published: March 2024

We describe a new class of the periodic banding of Ag2O precipitates through reaction–transport–reaction processes in an agarose-hydrogel column; the gel contains NaNO3 as an additive and is inserted between Ag and Ti rods with an applied constant voltage of 4.0–7.0 V. Submillimeter-scale periodic dark-brown precipitation bands were transiently generated with high reproducibility in this system, in which (i) electrochemical reactions at the metal rods to generate Ag+ and OH−, (ii) transportation of the reactant ions by the electric field, and (iii) reactions to produce Ag2O are expected to couple. The bands successively emerged mainly toward the cathode, accompanied by substantial changes in the electric current through the gel. The periodic banding depended on the applied voltage, duration of application, and concentration of NaNO3 initially loaded in the gel. The banding was most clearly observed in a 2.0 mass% agarose gel column containing 0.005 M NaNO3 under a constant applied voltage of ∼5.5 V for ∼3 h. This optimal condition resulted in more than ten periodic bands, of which the bandwidth (w) and the distance between the adjacent bands (d) were randomly distributed around the average values: for the bands formed up to 2 h, w = 0.25 ± 0.04 mm and d = 0.42 ± 0.05 mm; for the bands formed after 2 h, w = 0.42 ± 0.11 mm and d = 0.68 ± 0.07 mm. The generated periodic bands were gradually painted out with time to form an almost continuous broad band, even after the applied voltage was discontinued, although immersion of the gel in deionized water for 3 h could suppress this uniformization. Observations using optical and scanning electron microscopes with an energy-dispersive X-ray detector suggested that the periodic bands were composed of gelatinous Ag2O and micrometer-scale (1–50 μm) clusters, which comprised Ag-abundant nanoparticles with considerable size dispersion (10–500 nm). The relationship between the periodic banding and inhomogeneous distribution of the reactant ions and potential applications of the observed banding phenomena are discussed.
Efficient 10 ns-scale 2-μm optical parametric oscillator based on 1064 nm pump source
Authors: Chen Si-Ying , Yang Yun-Fei , Li Yun-Fei , Wang Gong , Yu Yu , Du Hai-Yang , Cao Feng-Li , Yin Hong-Wei , Zhu Chen-Yu , Wang Yu-Lei , Lu Zhi-Wei 
Published: March 2024

Lasers operating around 2-µm have been extensively researched for various applications, such as LiDAR, remote sensing, optical communication, and medicine. One of the approaches to generate 2-µm emission is to employ an optical parametric oscillator pumped by 1-µm laser; however, improving the 2-µm laser conversion efficiency of optical parametric oscillators is still a challenge. In this study, we exploit the high nonlinear coefficient of the KTP crystal at the 2-µm band to realize a high-efficiency optical parametric oscillator. The OPO is driven by a laser diode (LD) side-pumped, electro-optic Q-modulated Nd:YAG laser. The cavity was designed and optimized based on mode matching to increase the peak power density of the pump laser. Different powers were obtained for different pump laser focusing conditions, and the maximum power was obtained when the KTP crystal was placed in front of the pump laser focus. The output characteristics of the KTP at different phase-matching angles were also investigated. An output power of 2.44 W and an output pulse width of 9.04 ns were obtained at 2154.4 nm with an optical-to-optical conversion efficiency of 23.39% and a slope efficiency of 36.09%.
Lipid droplets in Arabidopsis thaliana leaves contain myosin-binding proteins and enzymes associated with furan-containing fatty acid biosynthesis
Authors: Omata Yuto , Sato Reina , Mishiro-Sato Emi , Kano Keiko , Ueda Haruko , Hara-Nishimura Ikuko , Shimada Takashi L. 
Published: March 2024

Lipid droplets (LDs) are lipid storage organelles in plant leaves and seeds. Seed LD proteins are well known, and their functions in lipid metabolism have been characterized; however, many leaf LD proteins remain to be identified. We therefore isolated LDs from leaves of the leaf LD–overaccumulating mutant high sterol ester 1 (hise1) of Arabidopsis thaliana by centrifugation or co-immunoprecipitation. We then performed LD proteomics by mass spectrometry and identified 3,206 candidate leaf LD proteins. In this study, we selected 31 candidate proteins for transient expression assays using a construct encoding the candidate protein fused with green fluorescent protein (GFP). Fluorescence microscopy showed that MYOSIN BINDING PROTEIN14 (MYOB14) and two uncharacterized proteins localized to LDs labeled with the LD marker. Subcellular localization analysis of MYOB family members revealed that MYOB1, MYOB2, MYOB3, and MYOB5 localized to LDs. LDs moved along actin filaments together with the endoplasmic reticulum. Co-immunoprecipitation of myosin XIK with MYOB2-GFP or MYOB14-GFP suggested that LD-localized MYOBs are involved in association with the myosin XIK–LDs. The two uncharacterized proteins were highly similar to enzymes for furan fatty acid biosynthesis in the photosynthetic bacterium Cereibacter sphaeroides, suggesting a relationship between LDs and furan fatty acid biosynthesis. Our findings thus reveal potential molecular functions of LDs and provide a valuable resource for further studies of the leaf LD proteome.
Comparative efficacy of non-electric cooling techniques to reduce nutrient solution temperature for the sustainable cultivation of summer vegetables in open-air hydroponics
Authors: Nisar Muhammad Mohsin , Mahmood Rashid , Tayyab Salman , Anees Moazzam , Nadeem Faisal , Bibi Sadia , Waseem Faiza , Ahmed Nazir , Li Jing , Song Zhao 
Published: March 2024

The cultivation of summer vegetables in open-air nutrient film technique (NFT) hydroponics is limited due to the elevated nutrient solution temperature (NST). In this regard, non-electric evaporative-cooling techniques were explored to maintain NST in open-air NFT hydroponics. Four cooling setups were employed by wrapping polyvinyl chloride (PVC) grow pipes with one and two layers of either wet or dry jute fabrics and attaching them with coiled aluminum pipe buried inside a) wet sand-filled brick tunnels (Cooling Setup I), b) two inverted and vertically stacked earthen pots (Cooling Setup II), c) two inverted and vertically stacked earthen pots externally wrapped with wet jute fabric (Wrapped Cooling Setup II), and d) an earthen pitcher wrapped with wet jute fabric (Cooling Setup III). Wrapping grow pipes with two layers of wet jute fabric reduced NST by 5°C as compared to exposed (naked) grow pipes. The double-layer jute fabric-wrapped grow pipes produced 182% more reduction in NST in comparison to single layer-wrapped grow pipes. Additionally, the installation of Wrapped Cooling Setup II and Cooling Setup III outperformed Cooling Setup I and Cooling Setup II through NST reduction of approximately 4°C in comparison to control. Interestingly, Cooling Setup III showed its effectiveness through NST reductions of 193%, 88%, and 23% during 11 a.m.–12 p.m. as compared to Cooling Setup I, Cooling Setup II, and Wrapped Cooling Setup II, respectively. In contrast, Wrapped Cooling Setup II caused NST reductions of 168%, 191%, and 18% during 2–3 p.m. in comparison to Cooling Setup I, Cooling Setup II, and Cooling Setup III, respectively. Thus, the double-layer jute fabric-wrapped grow pipes linked with Wrapped Cooling Setup II can ensure summer vegetable cultivation in open-air NFT hydroponics as indicated by the survival of five out of 12 vegetable plants till harvest by maintaining NST between 26°C and 28°C.
Relationship between positive parenting and cyberbullying perpetration among adolescents: role of self-esteem and smartphone addiction
Authors: Kim Ji Hye , Song Hye Young , Jung Gye Hyun 
Published: March 2024

IntroductionAdolescents may perpetrate cyberbullying in cyberspace, which they perceive as a medium of social communication, and cyberbullying perpetration is closely related to adolescent behavior, mental health, and development. This study aimed to examine the relationship of certain factors related to cyberbullying in adolescents using the framework of Jessor’s problem behavior theory.MethodsThis cross-sectional study investigated the mediating effect of adolescent self-esteem and smartphone addiction in the relationship between positive parenting and adolescent cyberbullying perpetration. The secondary analysis used data from the 2018 Korean Children and Youth Panel Survey. The data on positive parenting, adolescent self-esteem, smartphone addiction, and perpetration of cyberbullying of 2,394 Korean adolescents (boys: 1,297, 54.2%) were analyzed. Hayes’ PROCESS macro program was used to confirm the mediating role.ResultsThe results revealed that 26.5% (n = 634) of adolescents had perpetrated cyberbullying. Positive parenting did not directly relate to cyberbullying perpetration. Adolescent self-esteem and smartphone addiction played a mediating role between positive parenting and adolescent cyberbullying.DiscussionIndividual adolescent characteristics and parent/family system characteristics should be considered in policies aimed at preventing adolescent cyberbullying perpetration, preceded by the management of appropriate smartphone use. Improving young people’s self-esteem and teaching them how to use smartphones correctly can help prevent cyberbullying.
Sex differences in symptom network structure of depression, anxiety, and self-efficacy among people with diabetes: a network analysis
Authors: Wu Daoai , Shi Zhaoming , Wu Chenchen , Sun Weihua , Jin Guoxi 
Published: March 2024

AimsThe present study aims to explore the relations between symptoms of depression and anxiety and self-efficacy among people with diabetes. At the same time, we also examined the sex difference between network structures.MethodsThis study recruited 413 participants with diabetes, and they completed Generalized Anxiety Disorder Scale (GAD-7), Patient Health Questionnaire (PHQ-9), and the Self-efficacy for Diabetes (SED). Symptom network analysis and network comparison test were used to construct and compare the depression-anxiety symptom network models of the female and male groups. Finally, we conducted flow diagrams to explore the symptoms directly or indirectly related to self-efficacy.ResultsThe strongest edges in the depression-anxiety symptom networks are the edge between “GAD3” (Excessive worry) and “GAD4” (Trouble relaxing) and the edge between “PHQ1” (Anhedonia) and “PHQ4” (Energy) in the female and male groups, respectively. Most of the symptoms with the highest EI and bridge EI are related to worry and nervousness. Additionally, in the flow diagram of the female group, “PHQ6” (Guilt) has a high negative association with self-efficacy.ConclusionFemales with diabetes are more vulnerable to depression and anxiety. Interventions targeting key symptoms in the network may be helpful in relieving the psychological problems among people with diabetes.
Four weeks of meditation training improves sustained attention in community-dwelling older adults: a proof-of-concept randomized controlled trial
Authors: Ford Sabrina D. , Nagamatsu Lindsay S. 
Published: March 2024

Introduction: With our rapidly expanding population of older adults, identifying effective intervention strategies to improve cognitive functioning is an increasing priority. This study sought to examine whether 4 weeks of thrice-weekly meditation training can improve attention in older adults, as well as whether such benefits may extend to other domains of cognition as well as mobility.Methods: Forty-three participants (mean age 68 years) were randomized into either the focused attention meditation group or the music listening control group (Clinicaltrials.gov ID NCT03417635). Participants completed three 20-minute guided group sessions per week for four consecutive weeks. Our primary outcome measure was behavioural performance on the Sustained Attention to Response Task (SART). Secondary and tertiary outcome measures included event-related potentials (ERPs) during the SART task, measures of executive functioning, and measures of mobility.Results: We found that meditation training significantly improved attention, as demonstrated by improved SART accuracy and changes in N2 ERP amplitude and latency.Discussion: These findings suggest that meditation may lead to changes in attention and underlying cognitive processing in older adults, although a full-scale definitive trial is needed. Future research on the long-term benefits with real world applications is warranted.
Video games and disability—a risk and benefit analysis
Authors: Kuo Hung Jen , Yeomans Michael , Ruiz Derek , Lin Chien-Chun 
Published: March 2024

PurposeOver the past decades, video games have become a substantial part of the entertainment industry. While ubiquitous, video game participation remains low among people with disabilities amid potential negative effects. This article analyzes the risks and benefits that video games may present to individuals with disabilities.MethodologyIn this conceptual article, we explored the literature pertaining to video games and disability. To better understand the impact of video games on individuals with disabilities, we focused on the unique features of video games through the lens of the Self-Determination Theory.FindingsOur findings show that individuals with disabilities are most at risk from excessive video game use, leading to increased aggression, sedentary behavior, and negative impact on academic performance. Identified benefits include promoting physical rehabilitation and psychological well-being, improving cognitive abilities and emotional regulation, and utility in promoting exercises, and managing chronic pain.OriginalityThis article presents a number of strategies and resources to help guide individuals with disabilities, educators, practitioners, and researchers in maximizing the benefits of video games while controlling the risks.