bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of Streptococcus mutans endocarditis with cardiac surgical indication and complicated by spondylodiscitis after multiple dental procedures without antibiotic prophylaxis
Authors: Mazzotta Ruggero , Ciardetti Niccolò , Del Pace Stefano , Di Mario Carlo , Stefàno Pierluigi 
Published: April 2024

Background:
The association between Streptococcus mutans infective endocarditis and spondylodiscitis is extremely rare (only one case reported in the literature). Invasive dental procedures are known to increase the risk of infective endocarditis. European Society of Cardiology 2023 guidelines recommend antibiotic prophylaxis only in high-risk patients. However, these new guidelines do not consider the number of dental procedures performed in a short period of time.

Case Presentation:
We report the case of a patient affected by S. mutans infective endocarditis complicated by lumbar spondylodiscitis as a consequence of the performance of multiple dental procedures without antibiotic prophylaxis; this may be the first case characterized by this association and requiring cardiac surgery.

Conclusion:
These infective events occurred despite a proper interpretation of current guidelines about antibiotic prophylaxis but we believe that a case-by-case evaluation is useful to reduce the incidence of these complications. Specifically, it could be that the risk of developing endocarditis depends not only on the patient’s risk category but also on the number of dental procedures performed in a short period of time.
Insidensi dan Keparahan Penyakit Bercak Daun Disebabkan oleh Curvularia sp. pada Pembibitan Kelapa Sawit di Kabupaten Banyuasin Sumatera Selatan
Authors: Cameron Rizky Randal , Febrianni Astri , Yusticia Stenia Ruski 
Published: April 2024

In Indonesia, there has been a notable expansion in the area and productivity of oil palm plantations. Oil palm is among the top seven plantation commodities prioritized for development. High-quality seedlings are essential for optimal plant production. However, several factors can impede oil palm productivity, including diseases that affect oil palm seedlings. One such disease is brown spot disease caused by the fungus Curvularia sp. The objective of this study was to determine the incidence and severity of brown spot disease in oil palm seedlings. The research was conducted from May 2023 to June 2023 in Banyuasin Regency using a purposive sampling survey method. Thirteen seedling locations were selected based on their adherence to good seedling criteria. Seedlings aged 6-12 months were used in this study. At each location, five plots were surveyed, with 30-32 seedlings sampled per plot. Supporting data, including fertilization, watering, and herbicide and fungicide application, were tabulated to supplement the research findings. Results indicated that brown spot disease can affect plants as young as two weeks old. Initial symptoms include brown spots that eventually widen and merge with other spots. The average incidence of the disease was 93.29 % (± 7.89), with an average severity of 47.13% (± 13.23).
Long-term outcome of pediatric head injuries – A five-year follow-up
Authors: Rao Pinnaka Subba , Swamiyappan Sai Sriram , Puttagunta Sree Apoorva , Padmanabhan Ramachandran , Visveswaran Vivek 
Published: April 2024

Objectives:
Traumatic brain injury (TBI) disrupts the developing brain in the pediatric population. This study aims to look at the outcomes of moderate and severe TBI over a five-year follow-up to look for the long-term sequelae of head injury in the pediatric population.

Materials and Methods:
A prospective observational study was conducted after obtaining the permission of the Institutional Ethics Committee with the primary study participants admitted between 2015 and 2017 with follow-up extending up to 2022 in 118 pediatric patients, aged between 1 and 15 years who required admission in the pediatric intensive care unit with moderate and severe TBI.

Results:
Language impairment was noted in 33.63% (n = 37) patients during early follow-up, and 12 of them continued to have impaired language skills and communication at the end of five years. With regard to school functioning, children had more difficulty in the arithmetic domain (n = 33) compared to language domains (n = 17). While the parents noted improvements in scholastic performances, some degree of difficulty in learning was noted in most of the children, who sustained TBI. Despite these difficulties, 27 out of 41 participants, who gave their higher secondary examinations have gone on to pursue undergraduate courses in colleges.

Conclusion:
Our study indicates that over the passage of time, children tend to have a reasonable chance at recovery, and with the potential for plasticity, early and aggressive rehabilitative services may enable the child to have a decent quality of life and in selected cases, even an independent life.
Marian Kuna: Etika a politika v perspektíve Alasdaira MacIntyra
Authors: Synek Stanislav 
Published: April 2024

Studie nejprve stručně rekapituluje obsah knihy Mariana Kuny (Etika a politika v perspektivě Alasdaira MacIntyra) a snaží se ji kriticky zhodnotit. Poté se krátce věnuje dvěma tématům, klíčovým jak pro MacIntyra, tak pro jmenovanou knihu: otázce „univerzálních ctností“ a otázce pravdy. Zdá se totiž, že právě tyto dvě oblasti nejsou ani u jednoho ze zmiňovaných autorů uspokojivě řešeny.The study summarizes the book by Marian Kuna (Etika a politika v perspektivě Alasdaira MacIntyra) and aims to critically evaluate it. Then it gives a brief account of two topics crucial to both MacIntyre and Kuna: the problem of “universal virtues” and the problem of truth. It seems that neither of these is handled adequately in the works of the mentioned authors.
The Adolescent’s sexual behavior and its correlates: A Systematic Review
Authors: Hastuti Puji , Yunitasari Esti , Triharini Mira , Saidah Qoriila 
Published: April 2024

Abstract

Adolescents aged 13-15 years are a group vulnerable to risky sexual behavior. Many studies have been conducted to find the factors that influence it. This paper aims to analyze scientific evidence of factors that influence adolescent sexual behavior from various research results. The study design was a literature review on the adolescent population. Researchers conducted a literature search from empirical studies spanning the years 2017-2022 identified through the Scopus, Ebscohost, Science direct, Sage, Proquest, Springer Link and Google Scholar databases. The initial search found 8399 articles, which were narrowed down to 14 articles through inclusion criteria and exclusion criteria. The study includes research with various quantitative and qualitative designs taken from several countries. The data were analyzed using a qualitative synthesis approach. The results of the analysis show that there are many factors related to risky sexual behavior in adolescents. These factors are grouped into 4 major groups. Interpersonal factors (the role of peers), social environmental factors (economic activities, tourist interests, social norms,), individual factors (biological responses, ignorance, knowledge, lack of information, religious understanding, attitudes, self-esteem, motivation, use of social media), family factors (social economy, closeness of parents, communication between parents and children).
Keywords: Systematic review, sexual behavior, adolescents
Pembinaan Ibu Nifas Sebagai Upaya Peningkatan Keberhasilan Pemberian Asi Eksklusif Dengan Pemberian Edukasi Dan Ketrampilan Tentang Manajemen Laktasi
Authors: Kusniyati Etik , Purwati Heni 
Published: April 2024

Kegagalan dalam pemberian ASI Eksklusif di pengaruhi oleh faktor internal dan factor eksternal. Faktor internal meliputi rendahnya pengetahuan dan sikap ibu, pendidikan ibu, pekerjaan ibu, pendapatan keluarga dan penyakit ibu. Adapun factor eksternal meliputi kurangnya dukungan keluarga, masyarakat, petugas kesehatan maupun pemerintah, gencarnya promosi susu formula, faktor sosial budaya serta kurangnya ketersediaan fasilitas pelayanan kesehatan ibu dan anak. Keberhasilan menyusui ditunjang salah satunya dengan manajemen laktasi. Tujuan kegiatan pengabdian ini untuk meningkatkan pemahaman masyarakat khususnya ibu nifas tentang Manajemen laktasi dalam upaya peningkatan keberhasilan pemberian asi eksklusif. Metode yang dilakukaan pada kegiatan pengabdian ini adalah dengan melakukan penyuluhan dan pemutaran video kepada 18 ibu nifas di TPMB Fifin N.I.S., Amd.Keb. Berdasarkan hasil pre-test menunjukkan rata-rata skor nilai adalah74,00. Post test dilakukan setelah ibu nifas diberikan edukasi, hasil post test menunjukkan bahwa rata-rata skor nilai 88,22. Hasil uji statistik dengan menggunakan uji Wilcoxon Signed Rank Test, diketahui nilai ?-value = 0,000 (?-value <0,05) yang berarti terdapat perbedaan skor yang signifikan sebelum dan sesudah dilakukan pendidikan kesehatan tentang manajemen laktasi. Ada selisih 14,220 antara pre test dan post test. Pendidikan Kesehatan salah satunya adalah dengan penyuluhan perlu ditingkatkan sebagai upaya untuk mendukung keberhasilan program laktasi.
MAINTENANCE STRATEGY REVIEW (MSR) BASED ON ISO 14224:2016 IN INDONESIA OIL AND NATURAL GAS COMPANIES
Authors: Setyoko Ajun Tri , Nurcahyo Rahmat , Adipraja Aulia Sena , Budiono Hendri Dwi Saptrioratri 
Published: April 2024

<p>The oil and gas industry is vital for Indonesia, and the safety and effectiveness of work in processing and exploring the oil and gas that operate in Indonesia must comply with existing regulations. This safety and effectiveness are inseparable from how the company maintains the assets and instruments used at the oil and gas production and exploration site. Maintenance of pipes and instruments for production is one of the company's most vital assets. In addition to having appropriate productivity, pipes and instruments must be maintained optimally so that maintenance costs do not exceed the value of the oil and gas production. This study's research subject is a natural gas refinery from an oil and gas company operating in the Madura Strait, East Java, Indonesia. The object of research limited to the company's piping system (pipeline system). This study uses a quantitative assessment using the calculated Mean Time Before Failure (MTBF) method and a qualitative assessment using the asset maintenance standard to reveals how the maintenance cycle that has been implemented can be optimized. The author carried out a criticality assessment using Maintenance Strategy Review (MSR) to calculate the risk level of asset. This study found that 78 assets must be maintained in their maintenance cycle, two cash assets must be reduced in their maintenance cycle, and seven assets can be extended for their maintenance cycle. The two assets that need to be reduced in maintenance cycles are the shutdown valve asset that goes to the temporary pig receiver and the shutdown valve that goes to the HP flare header. An asset that can be extended its maintenance cycle is a transmitter for flow indicators.</p><div><div><p> </p></div></div>
Hubungan Antara Volume Ambing Dan Panjang Puting Terhadap Produksi Susu Sapi Perah Friesian Holstein Di Desa Pesanggrahan Kota Batu
Authors: Marshaniswah Ignacia Farah , Surjowardojo Puguh 
Published: April 2024

The Purpose of this study was to determine the relationship between udder volume and teats length with milk production in Friesian Holstein dairy cows in Pesanggrahan Village, Batu City, East Java. The research was conducted for one month from August to September 2023. The materials used were 30 Friesian Holstein dairy cows in lactation phase 2-3 and lactation month 2-3. The method used was case study method. Parameters measured included udder volume, teats length and milk production. Analysis of the relationship between research variables using correlation analysis and simple linear regression, where udder volume and teats length as independent variables (X) and milk production as the dependent variable (Y). The results showed that there was a relationship between udder volume and milk production and a very weak relationship between teats length and milk production. The conclusion of this study is that udder volume has a relationship with milk production, while teats leght has a insignificant relationship with milk production so that teats leght only affects milking effectiveness. Thus, udder volume is a considered more relevant as a variable in predicting the amount of milk produced by dairy cows. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara volume ambing dan panjang puting dengan produksi susu pada sapi perah Friesian Holstein di Desa Pesanggrahan, Kota Batu, Jawa Timur. Penelitian dilakukan selama satu bulan dari bulan Agustus hingga September 2023. Materi yang digunakan adalah 30 ekor sapi perah Friesian Holstein periode laktasi II-III dan laktasi bulan ke 2-3. Metode yang digunakan adalah metode studi kasus. Parameter yang diukur meliputi volume ambing, panjang puting dan produksi susu. Analisis hubungan antar variabel penelitian menggunakan analisis korelasi dan regresi linier sederhana, dimana volume ambing dan panjang ambing sebagai variabel bebas (X) dan produksi susu sebagai variabel terikat (Y). Hasil penelitian menunjukkan bahwa terdapat hubungan antara volume ambing dengan produksi susu dan terdapat hubungan yang sangat lemah antara panjang ambing dengan produksi susu. Kesimpulan dari penelitian ini adalah volume ambing memiliki hubungan dengan produksi susu, sedangkan panjang ambing memiliki hubungan yang tidak signifikan dengan produksi susu sehingga panjang ambing hanya berpengaruh terhadap efektivitas pemerahan. Dengan demikian, volume ambing dianggap lebih relevan sebagai variabel dalam memprediksi jumlah susu yang dihasilkan oleh sapi perah
Księdza Profesora Jana Szymczyka narracja socjologiczna o wartościach
Authors: Mariański Janusz 
Published: April 2024

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Ksiądz Jan Szymczyk prowadził swoje badania nad życiem społecznym z perspektywy socjologiczno-aksjologicznej. Idąc tropem jego rozważań, spróbujemy od strony teoretycznej zaprezentować jego socjologiczne rozumienie wartości, przedstawić teoretyczne aspekty modelu badawczego orientacji wartościujących oraz w skrócie zarysować koncepcję transformacji wartości w społeczeństwie polskim. Wartości rozumie się jako duchowe, moralne przekonania podstawowe, kierujące postawami i wzorami zachowań jednostek. Jeżeli zmieniają się wartości, zmieniają się również zależne od nich postawy i wzory zachowań. Wartości mają charakter bardziej ogólnych i trwałych orientacji, określających perspektywy życia codziennego, jego sens i znaczenie, a także wyznaczają pośrednio normy określające konkretne działania. Wartości pojmowane jako cele działań funkcjonują w świadomości jednostek, są uruchamiane i aktualizowane w określonych kontekstach i sytuacjach, kiedy pojawiają się odpowiednie racje, motywacje czy wyzwania. Odgrywają one szczególną rolę w systemie przekonań każdej osoby. Coś jest wartością dla kogoś albo coś ma wartość dla kogoś. Ostatecznie wartość jest wynikiem relacji doznającego i aktywnego podmiotu wobec pewnych przedmiotów świata zewnętrznego.
Perspektywa aksjologiczna, którą przyjmuje ks. Jan Szymczyk, stanowi jedno z najbardziej istotnych pojęć badawczych, umożliwiających oglądy i konstruowanie obrazów konkretnych podmiotów i fenomenów życia społecznego. Zastosowanie (aplikacja) tej perspektywy sprawia, że badania socjologiczne prowadzone z punktu widzenia wartości (ich deklarowanie, a zwłaszcza uznawanie i internalizowanie), dostarczają wielu cennych informacji na temat jakości i kondycji różnych form i struktur życia publicznego. Akceptowany zbiór czy układ wartości niejednokrotnie przekłada się na afirmowany styl życia, mentalność oraz określoną tożsamość społeczną i strategię działań jednostek i różnych aktorów społecznych. Często zamierzeniem badacza nie jest bezpośrednia charakterystyka wartości jako wartości, ale raczej odkrywanie ich w sposobach myślenia o polityce, gospodarce, życiu publicznym, w kulturze, czyli przy okazji omawiania zasadniczych kwestii, stanowiących przedmiot teoretycznych analiz i badań socjologicznych.
Perspektywa psychospołeczna czy relacjonistyczna, którą przyjmuje w swoich badaniach socjologicznych nad wartościami Jan Szymczyk, pozwala mu na relatywnie zintegrowany ogląd zróżnicowanych postaw, jakie podmioty (jednostki) zajmują wobec wartości. Wartości mogą być ujmowane jako istniejące w przedmiotach materialnych i niematerialnych (rozumienie przedmiotowe). Po drugie, utożsamia się je z działaniami, czyli związane są z samą relacją, jaka dokonuje się pomiędzy podmiotem a przedmiotem (rozumienie „pośrednie”). Po trzecie, kategorie aksjologiczne sytuują się w doświadczeniu człowieka (rozumienie podmiotowe).
The P-element Has Not Significant Effect on the <i>Drosophila simulans</i> Viability
Authors: Zakharenko L. P. , Petrovskii D. V. , Bykov R. A. 
Published: April 2024

Cases of horizontal transfer of transposable elements (TEs) between species are known for the Drosophilidae family. In the middle of the last century, the case of horizontal transfer of the P-element from the Drosophila willistoni to the D. melanogaster was described. A novel P-element invasion into the D. simulans genome from D. melanogaster occurred approximately 10 years ago. Currently, the P-element has spread across all D. melanogaster population and 30% of D. simulans populations in Europe, Africa and America. In this paper, we investigated the presence of the P-element in D. simulans lines caught in different years in three Asian populations (Tashkent, Nalchik and Sakhalin Island). We also examined the physiological characteristics (cytotype, lifespan, fecundity and locomotor activity) of D. simulans lines with and without the P-element to determine the significance of this new mobile element in the genome. The P-element was found in lines isolated from nature after 2012. The number of P-element copies per genome (two-to-three dozen according to fluorescence in situ hybridization data) was greater than in the American and comparable to the African populations. There were signs of intraspecific hybrid dysgenesis for some pairs of lines. However, in general the presence of the P-element did not adversely affect the physiological characteristics. Either adaptation to the new TE occurs very quickly, or the rate of movement of the P-element is so insignificant that its appearance in the genome remains unnoticed.
Oxidative Probing of the G4 DNA Structure by ZnP1 Porphyrin within Sequences of <i>MYC</i> and <i>TERT</i> Promotors
Authors: Chashchina G. V. , Kaluzhny D. N. 
Published: April 2024

The formation of G4 structures in a DNA double helix competes with the complementary strand, which can change the equilibrium G4 structures studied on single-strand models by classical structural methods. A relevant task is to develop methods for detecting and localizing G4 in extended double-stranded (ds) DNA in the promoter regions of the genome. The porphyrin derivative ZnP1 selectively binds and leads to photo-induced oxidation of guanine in G4 structures on single-stranded (ss) and dsDNA model systems. In this research, we show the oxidative effect of ZnP1 on native sequences of MYC and TERT oncogene promoters that potentially capable to form G4 structures. Single strand breaks in the guanine rich sequence caused by ZnP1 oxidation and subsequent cleavage of the DNA strand by Fpg glycosylase were identified and assigned to the nucleotide sequence. The detected break sites corresponded to sequences potentially capable of forming G4 structures. New data were obtained on the possibility of folding G4 structures in the presence of a complementary strand in the context of the DNA double helix of the natural sequence.
Universal Panel of Insertion–Deletion Polymorphism for Human Genetic Identification and a Biochip-Based Kit <i>ChipID106</i> for This Purpose
Authors: Fesenko D. O. , Ivanovsky I. D. , Ivanov P. L. , Zemskova E. Yu. , Polyakov S. A. , Fesenko O. E. , Filippova M. A. , Zasedatelev A. S. 
Published: April 2024

The paper proposes a panel of 106 insertion–deletion (InDel) polymorphisms and practical testing of the method of their genotyping on biochips. Such fundamental properties of InDel markers as short length and low mutation rate provide them with significant advantages in expert practice over widely used tandem repeats (STRs). In this work, we analyzed the allele distribution of InDel polymorphisms in the five largest world populations (European, East Asian, South Asian, African and American), and selected markers that meet the following criteria: minor allele frequency of more than 0.30, physical distance between markers more than 3 million bp, the absence of polymorphisms, tandem repeats and palindromes in the flanking sequences, the proximity of the AT/GC ratio to 1. As a result, a panel of 106 polymorphisms was formed with an average frequency of the minor allele for all five populations of 0.396. For panel genotyping, a method was developed that included one-step multiplex PCR followed by hybridization on a biological microarray. The average amplicon length was 72 bp. On a sample of 201 residents of Moscow and St. Petersburg, the main characteristics of the formed panel were determined: the probability of a random match (MP) 1.89 × 10–43, the paternity exclusion potential (CPE) 0.99999999063. The proposed method is an alternative to molecular genetic identification of a person based on variations in the lengths of STR loci.
Mechanism of Bimodal Effect of DL-Butyonine Sulfoximine of Constitutive Androstane and Pregnane X Receptors <i>in vitro</i>
Authors: Abalenikhina Y. V. , Shchulkin A. V. , Seidkulieva A. A. , Rokunov E. D. , Gadzhieva F. T. , Yakusheva E. N. 
Published: April 2024

The constitutive androstane receptor (CAR) and the pregnan X receptor (PXR) are nuclear receptors that are involved in the regulation of gene transcription of enzymes responsible for biotransformation and excretion of endo- and xenobiotics. The aim of the study was to study the effect of DL-butyonine sulfoximine (BSO, gamma-glutamylcysteine synthetase inhibitor) on the relative amount of CAR and PXR in Caco-2 cells and to evaluate its mechanisms. BSO was used in concentrations of 1‒500 μM and exposure duration of 24 and 72 h. The generation of reactive oxygen species (ROS) was determined using MitoTracker Red CM-H2 XRos fluorescent probes. Cytotoxicity was analyzed according to the results of the MTT test. The relative amount of CAR and PXR was estimated by the Western blot method. It was shown that BSO caused an increase in the formation of ROS at exposure duration of 24 h at concentrations of 10, 50 and 100 μM, at 72 h – at concentrations of 50, 100 μM. At the same time, at a concentration of 500 μM, BSO reduced the viability of cells during all periods of exposure. The relative amount of CAR increased at BSO concentrations of 50, 100 μM and exposure duration of 24 hours and 10, 50 μM at exposure of 72 h, and PXR – at concentrations of 100 and 500 μM and incubation of 24 h and 50, 100, 500 μM and incubation of 72 h. When used together with BSO, glutathione, the synthesis of which it blocks, it was found that at exposure time of 24 h and BSO concentrations of 50 μM and 72 h and concentrations of 10 and 50 μM, CAR induction was suppressed, and at 50 and 100 μM and exposure time of 72 h – PXR. The introduction of glutathione into the nutrient medium with BSO had no effect on PXR at xenobiotic concentrations of 100 and 500 μM (24 h) and 500 μM (72 h), on CAR – at concentrations of 100 μM (24 h) and 50 and 100 μM (72 h). Thus, BSO can induce CAR and PXR both by increasing the production of free radicals and the development of oxidative stress, and independently as a xenobiotic.