bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatocellular Carcinoma Detection by Cell Sensor Based on Anti-GPC3 Single-Chain Variable Fragment
Authors: Yan Zupeng , Che Ziyuan , Shi Zhenghan , Lv Jingjiang , Yang Linhe , Lu Tianhao , Lu Yanli , Shan Jianzhen , Liu Qingjun 
Published: March 2024

Precise identification of hepatocellular carcinoma (HCC) in early stages remains both a challenge and an opportunity for prevention and diagnosis of early liver cancer. Fast-detecting techniques like electrochemical sensing might provide more insight than current clinical methods owing to its high sensitivity, rapid detection, and convenient operation. Here, a single-chain variable fragment (scFv) was designed by retaining the antigen binding active sites of a recombinant humanized monoclonal antibody and modifying with histidine tags, and consequently used for the construction of cell sensor for HCC detection. The customized scFv showed specific binding signature on the membrane of HCC cell and positive correlation with cell concentration using fluorescence confocal microscopy and flow cytometry, respectively. A higher binding affinity of scFv over the original monoclonal antibody was also displayed. After the immobilization onto the screen-printed electrode through the high affinity between histidine and nickel-based nanomaterial, the constructed cell sensor exhibited a wide detection range of 10
2
to 10
7
cells ml
−1
and a low detection limit of 2 cells ml
−1
with a short incubation time of 5 min. The high selectivity in the liver tissue extract fluid derived from the design strategy was also displayed in the mouse samples. The customized scFv and related cell sensor demonstrated great potential for fast HCC analysis in early-stage cancer diagnosis.
Magnetic Soft Microrobot Design for Cell Grasping and Transportation
Authors: Wang Fanghao , Zhang Youchao , Jin Daoyuan , Jiang Zhongliang , Liu Yaqian , Knoll Alois , Jiang Huanyu , Ying Yibin , Zhou Mingchuan 
Published: March 2024

Manipulating cells at a small scale is widely acknowledged as a complex and challenging task, especially when it comes to cell grasping and transportation. Various precise methods have been developed to remotely control the movement of microrobots. However, the manipulation of micro-objects necessitates the use of end-effectors. This paper presents a study on the control of movement and grasping operations of a magnetic microrobot, utilizing only 3 pairs of electromagnetic coils. A specially designed microgripper is employed on the microrobot for efficient cell grasping and transportation. To ensure precise grasping, a bending deformation model of the microgripper is formulated and subsequently validated. To achieve precise and reliable transportation of cells to specific positions, an approach that combines an extended Kalman filter with a model predictive control method is adopted to accomplish the trajectory tracking task. Through experiments, we observe that by applying the proposed control strategy, the mean absolute error of path tracking is found to be less than 0.155 mm. Remarkably, this value accounts for only 1.55% of the microrobot’s size, demonstrating the efficacy and accuracy of our control strategy. Furthermore, an experiment involving the grasping and transportation of a zebrafish embryonic cell (diameter: 800 μm) is successfully conducted. The results of this experiment not only validate the precision and effectiveness of the proposed microrobot and its associated models but also highlight its tremendous potential for cell manipulation in vitro and in vivo.
Harnessing Renewable Lignocellulosic Potential for Sustainable Wastewater Purification
Authors: Wang Bin , Wang Jiaming , Hu Zhaohui , Zhu An-Ling , Shen Xiaojun , Cao Xuefei , Wen Jia-Long , Yuan Tong-Qi 
Published: March 2024

Utilizing renewable lignocellulosic resources for wastewater remediation is crucial to achieving sustainable social development. However, the resulting by-products and the synthetic process characterized by complexity, high cost, and environmental pollution limit the further development of lignocellulose-based materials. Here, we developed a sustainable strategy that involved a new functional deep eutectic solvent (DES) to deconstruct industrial xylose residue into cellulose-rich residue with carboxyl groups, lignin with carboxyl and quaternary ammonium salt groups, and DES effluent rich in lignin fragments. Subsequently, these fractions equipped with customized functionality were used to produce efficient wastewater remediation materials in cost-effective and environmentally sound manners, namely, photocatalyst prepared by carboxyl-modified cellulose residue, biochar-based adsorbent originated from modified lignin, and flocculant synthesized by self-catalytic in situ copolymerization of residual DES effluent at room temperature. Under the no-waste principle, this strategy upgraded the whole components of waste lignocellulose into high-value-added wastewater remediation materials with excellent universality. These materials in coordination with each other can stepwise purify high-hazardous mineral processing wastewater into drinkable water, including the removal of 99.81% of suspended solids, almost all various heavy metal ions, and 97.09% chemical oxygen demand, respectively. This work provided promising solutions and blueprints for lignocellulosic resources to alleviate water shortages while also advancing the global goal of carbon neutrality.
The Node Security Access Authentication Method for Mega-Constellation based on Sharding Blockchain
Authors: Li Zongling , Long Teng , Zhao Baojun , Qiu Wangjie 
Published: March 2024

The mega-constellation is a major future development direction for space-based technologies in communications, navigation,remote sensing, and other fields. However, there are marked security threats to the mega-constellation. Traditional password-based security protection techniques are inefficient for vast node access authentication because they lack a unified management system and methodology. To address the aforementioned issues, this work presents a mega-constellation node security access authentication technique based on sharding blockchain via the “1 +
N
+ 1” mega-constellation security and trustworthiness architecture. We build a distributed node security access authentication system based on functional domains and functional cross-domains, and we develop mathematical models for the complexity of messaging and space, the throughput of transactions, and the overall estimation of sharding blockchain systems. The results demonstrate that every indicator outperforms conventional blockchain techniques, which has major implications for mega-constellation by creating a complete link security and trustworthiness system. A universal solution for the number of consensus nodes
I
and the number of shards
N
is found, which can be used to guide parameter design in mega-constellation sharding blockchain systems.
Analisis Penggunaan Paylater Untuk Belanja Online Mahasiswa di Surabaya Pada Masa New Normal
Authors: Ansar Muhammad Armando Nur Rizqy , Nurfatikha Rih Prajna , Saraswati Ni Putu Septiary Devi , Rakhmawati Nur Aini 
Published: March 2024

Pertumbuhan e-commerce di Indonesia setiap tahunnya semakin meningkat. Berbagai kemudahan yang ditawarkan e-commerce menarik atensi masyarakat untuk melakukan belanja online. Pertumbuhan e-commerce juga diikuti dengan perkembangan metode pembayaran di e-commerce yang semakin beragam sehingga mempermudah transaksi para penggunanya. Dalam beberapa tahun terakhir, metode pembayaran paylater menarik perhatian masyarakat Indonesia karena kemudahan yang ditawarkannya. Metode penelitian yang digunakan yaitu metode kuantitatif dengan survei online untuk mengumpulkan data penelitian. Survei online dilakukan oleh 74 responden dengan kriteria mahasiswa di kota Surabaya yang pernah melakukan belanja online dalam waktu 6 bulan terakhir. Hasil penelitian ini menunjukkan bahwa penggunaan metode pembayaran paylater pada masa new normal kurang diminati oleh mahasiswa. Hal ini terlihat dari total 74 responden, hanya 16,27% responden yang pernah menggunakan metode pembayaran paylater untuk menyelesaikan transaksi belanja online mereka.
Utilization of Zakat, Infaq, Alms, Waqf (ZISWAF) and the Blessed Friday Phenomenon
Authors: Mar'atush Shalihah Bunga , Hidayat Fajri Nur , Amelia Riski 
Published: March 2024

In Islam, Friday is a very special day. In Muslim belief, Friday is considered a blessed and sacred day. In addition, understanding the importance of sharing sustenance is also an important part of the teachings of Islam. One of the forms of sharing sustenance recommended in Islam is by carrying out ZISWAF (Zakat, Infaq, Shadaqah, Waqf). The utilization of Ziswaf (Zakat, Infaq, Shadaqah, and Waqf) is one of the efforts made by Muslims in realizing social justice and the economic empowerment of the people. On the other hand, the Friday Blessing phenomenon is a popular tradition among Muslims, where people compete to give alms on Friday in the hope of getting multiple blessings. In this article, the author will discuss the link between the Blessed Friday phenomenon and Ziswaf utilization. The author will explain why Blessed Friday is the right moment for Ziswaf utilization, as well as the benefits of both.
Effects of Joint Gymnastics Exercise Intervention on Improving Functional Ability of the Elderly
Authors: Caturini Endang , Ariani Dwi , Khadijah Siti 
Published: March 2024

Background: The elderly experience changes in the musculoskeletal system in the form of joint disorders that attack the joints and supporting tissue structures around the joints causing pain, loss of physical function, and disability. This requires management to reduce joint pain and improve muscle movement, function, strength, and endurance using joint gymnastics/rheumatism. The purpose of this study was to improve the ability of physical functioning in the elderly.
Methods: Quasi-experimental research with pre-post test design. The number of samples was 42 elderly people. This study measured the ability of physical function in the elderly. The research instrument used the KOOS (Knee injury and Osteoarthritis Outcome Score) questionnaire. Data were analyzed using the Wilcoxon signed ranks test.
Results: Research shows the majority of respondents are > 59 years old, and the majority are women (62.2%). There was an increase in knowledge with an increase in score of 2.19 and functional ability with an increase of 21.71 which was described in 4 sections, namely for pain score increased by 7.59, sign and symptom score increased by 7.09, ADL score increased by 2.76 and quality of life score increased by 4.26. There was a significant effect (p = 0.000) of joint gymnastics training interventions on improving knowledge and functional abilities.
Conclusion: There is an effect of joint gymnastics exercise interventions on improving knowledge and functional abilities. Suggestion: the application of joint gymnastics exercises is needed as an additional intervention in the community and to improve functional ability in the elderly.
Mortalidad por COVID-19 en las regiones del Perú entre la primera y la quinta ola pandémica
Authors: Fabian-Moya Sthefani Paola , Zegovia-Santos Luz Nélida 
Published: March 2024

Objetivo. Determinar la mortalidad por COVID-19 en las regiones del Perú entre la primera y la quinta ola pandémica. Métodos. La investigación fue analítica, observacional, retrospectiva y de corte transversal. La data fue obtenida de la Plataforma Nacional de Datos Abiertos del Ministerio de Salud (MINSA) y delSistema Informativo Nacional de Defunciones (SINADEF) e importada en formato Microsoft Excel al programa estadístico SPSS v.25. Para la fcha de recolección de datos fueron consideradas las variables: edad, sexo, criterios de diagnósticos y regiones. Para el análisis estadístico se utilizaron las pruebas no paramétricas deKruskal-Wallis y Mann-Whitney. Resultados. Se reportaron 218 770 fallecidos durante el periodo 2020-2022, con una tasa de mortalidad (TM) de 744,6 x 100 000 habitantes; el 44,1 % pertenecientes al departamento de Lima, en su mayoríaadultos mayores de sexo masculino. La concentración según macroregión fueron principalmente: en Lima con una TM de 1,022 x 100 000 habitantes, y el norte con una TM de 634 x 100,000 habitantes. Por otro lado, el criterio de diagnóstico virológico en un 37,7 % seguido del SINADEF con 30,3 %. Así mismo, se muestran diferencias signifcativas en los rangos de las variables con un p < 0,05 (0,000).Conclusiones. La mortalidad por COVID-19 en el Perú fue alta, con una tasa de mortalidad de 744,6 x 100,000 habitantes, independientemente del sexo, edad, región y criterios de diagnóstico; liderando el Departamento de Lima.
Risques globaux et dynamiques regionales dans le secteur bancaire face un défi climatique : chronique d’une faillite annoncee ?
Authors: Relano Francesc , Paulet Elisabeth 
Published: March 2024

Cette étude montre comment les enjeux climatiques affectent la santé des entreprises au travers du financement bancaire et, à l’inverse, comment l’activité de crédit et d’investissement de ces derniers influence le changement climatique. Empiriquement, cette boucle s’appuie sur l’étude des Etats-Unis et du Canada. Plus précisément, deux indicateurs (un « compensateur-carbone » et un ratio (actifs fossiles/capitaux propres) permettent d’évaluer la situation de leurs institutions financières sur ce double enjeu. Les résultats montrent le fort retard des banques Nord-Américaines dans l’apprivoisement des risques climatiques, compromettent le bon fonctionnement de leurs écosystèmes entrepreneuriaux. Pourtant, les deux pays auraient intérêt (au niveau climatique et financier) à anticiper une transition ordonnée de leurs réseaux bancaires et entrepreneuriaux vers les objectifs climatiques fixés intentionnellement.
Pyloric atresia and epidermolysis bullosa: A fatal association
Authors: Kundu Soham , Mahapatra Alapan , Halder Dhrubajyoti , Halder Pankaj Kumar 
Published: March 2024

Abstract
Pyloric atresia (PA) contributes less than 1% of all gastrointestinal atresias with an incidence of 1 in 100,000 newborns. It is often associated with epidermolysis bullosa (EB) or aplasia cutis congenita. This association is believed to be lethal because of the increased risk of developing septicemia, electrolyte imbalance, and protein loss. Here, we attempt to highlight the fatal complications of PA with EB in a 10-day-old female baby and reevaluate the representative features that an astute clinician needs to be aware of.
Caregivers’ knowledge, perception, and management of childhood pneumonia: A study in tribal district of India
Authors: Kulkarni Prashant , Mahajan Uma , Kurane Anjali 
Published: March 2024

Abstract

Introduction:
Childhood pneumonia, if identified early, is readily treatable through low-cost antibiotics. The study aimed to understand the family caregivers’ knowledge and care-seeking behavior for the management of childhood pneumonia. The study was cross-sectional, with mixed methods assessing knowledge, perceptions, and practices of caregivers of under-five children on pneumonia using a vignette.

Methodology:
Systematic random sampling was used to select the participants. Of 107, more than half of the respondents were 18–25 years old.

Results:
Less than one-fourth were illiterate. Cough, flu, and stomach distention were the commonly reported symptoms. Food ingestion was reported as a main perceived cause; private doctors and traditional healers were the most reported source of help-seeking. Friend/family were reported as leading sources of information. Health education is to be imparted using local knowledge regarding childhood pneumonia. Traditional healers and private practitioners sensitize in early management and referral of childhood pneumonia cases.

Conclusions:
Information, education and communication messages need to be prepared in the local languages. Strengthening the public health sector is suggested.
Standard Snodgrass urethroplasty versus Snodgrass with glans augmentation urethroplasty for distal hypospadias: A comparative study
Authors: Tanger Ramesh , Prajapati Sahaj , Gupta Pradeep , Gupta Rahul , Rengan Vinayak , Varma Aseesh 
Published: March 2024

Abstract

Introduction:
Hypospadias is one of the most common congenital anomalies of the male genitourinary system. The Snodgrass urethroplasty is the most common worldwide accepted procedure for distal hypospadias. Various modifications have been made to reduce common complications, such as urethra-cutaneous fistula and meatal stenosis. In this study, we compare the results of hypospadias repair using the standard Snodgrass urethroplasty technique and Snodgrass urethroplasty with glans augmentation.

Materials and Methods:
This is a single institution series from January 2020 to January 2023. One hundred patients with distal hypospadias were included in the study. Out of these, 50 patients underwent the standard Snodgrass repair (Group 1), whereas another 50 patients underwent the Snodgrass urethroplasty with glans augmentation technique (Group 2).

Results:
The average follow-up period was 8 months. Four patients in Group 1 developed a fistula, and three had meatal stenosis (two were managed by meatal dilatations, and one with severe meatal stenosis was managed by meatotomy). In comparison, none of the patients in Group 2 developed a fistula, and only one developed meatal stenosis, which was managed by meatal dilatation. Partial skin necrosis was noted in three patients in Group 1 and two patients in Group 2. The final cosmetic appearance was acceptable.

Conclusions:
Snodgrass urethroplasty with glans augmentation is an effective procedure with a low complication rate and good cosmetic results.
Yoga practices and sattvic ahar in the management of overweight and obesity: Four case studies
Authors: Rajbhoj Pratibha Hemant , Pathak Satish Dattatray , Bhogal Ranjeet Singh , Pandey Santosh 
Published: March 2024

Abstract
The advent of the twenty-first century has evidenced a significant change in our lifestyles, leading to a sedentary way of living resulting in an imbalanced food consumption and output in the form of energy expenditure. Furthermore, modern individuals have developed new habits of consuming unethical, unhealthy, and incompatible food combinations to cater to their taste preferences and to indulge in addictive eating patterns. Media advertisements further promote such food consumption, diverting attention away from nutritious traditional food habits. A case study was conducted on four individuals belonging to the obesity classes I, II, and III. The study intervention consisted of a yoga regimen and sattvic ahar for 7 days. In the study, body weight, blood pressure, bioelectrical impedance, body mass index (BMI), muscle mass, and body fat percentage were measured. Data were collected twice: at the beginning and the end of the study. Postintervention results showed a remarkable reduction in average body weight, BMI, and fat percentage compared with the baseline results. In addition, the average bioelectrical impedance and muscle mass of these four subjects increased notably. Based on the findings of this study, it can be concluded that a regular practice of yoga and adherence to a sattvic diet may prove effective in weight management. Future research should explore the long-term effects of this practice and sattvic ahar on weight management, as well as, their possible implications for overall health and wellbeing. Additionally, further research should include different demographic groups to validate the effectiveness of the intervention comprising yoga and a sattvic diet.
Agrawal and Shah Modified Cast Index – A Novel Index Assessing Prevalence of Dental Caries and Treatment Needs of the Adult Indian Population
Authors: Agrawal Vineet , Shah Nimisha 
Published: March 2024

Background:
Agrawal and Shah modified CAST (Caries Assessment Spectrum and Treatment) is the novel index prepared specifically for the Indian population for the complete evaluation of the spectrum/range of dental caries described hierarchically.

Objective:
To assess the prevalence of dental caries and treatment needs in an adult Indian population using Agrawal and Shah modified CAST index.

Materials and Methods:
A cross-sectional transverse study was performed on 2000 adult patients in the age range of 19–70 years. All the adult patients were scored for caries presence by Agrawal and Shah modified CAST codes on a structured proforma. SPSS version 20 was used to analyze the data.

Results:
The prevalence of dental caries calculated using Agrawal and Shah modified CAST index was 85.6%. 5.2% (104) adults had sound dentition, 4.1% (82) adults had restorations, 2.1% (42) adults had non-cavitated lesions, 13.7% (274) adults had the presence of caries in the enamel, 19% (380) adults had the presence of caries in dentine, and pulpal involvement was observed in 27.7% (554) adults. 10.3% (206) adults had presented with a root surface and cervical caries. 13.6% (272) adults had lost at least one tooth due to caries, and 3% (60) adults had lost teeth due to any other reason except dental caries. 1.3% (26) adult patients do not show any caries-related diagnosis but were having predisposing conditions.

Conclusion:
Agrawal and Shah modified CAST index proved to be simple, useful, and appropriate in assessing dental caries prevalence in the Indian population along with the treatment needs of the Indian population.
Prevalence and Determinants of Low Birth Weight among the Newborns in Dadra and Nagar Haveli: A Community-based Study
Authors: Jangid Sunil , Chauhan Pooja , Mehta Vaibhav , Patel Mitali , Mahyavanshi Darshan , Das Vatte Katte 
Published: March 2024

Background:
The world is not on track to meet the World Health Assembly (WHA) global target on Low Birth Weight (LBW). To estimate the prevalence and to identify the associated determinants of LBW among the newborns.

Material and Methods:
We conducted a cross-sectional study among the 364 mothers registered under the all government health facilities of Dadra & Nagar Haveli (DNH) during November 2021 to January 2022.

Results:
The prevalence of LBW was found to be 39%. On uni-variable logistic regression, live in relationship, caste, weight of mother, Body Mass Index (BMI), weight gain <5 kg in 2nd and 3rd trimester, high-risk pregnancy, complication present in previous pregnancy and preterm delivery, while on multi-variable logistic regression, weight gain <5 kg in 2nd and 3rd trimester (AOR 2, 95% CI 1.007-4.2) and having high-risk pregnancy (AOR 2, 95% CI 1.1-3.0) were found to be the significant predictors of LBW among the newborns.

Conclusions:
We conclude from the study that the prevalence of low birth weight among the newborn was high. There is a need to address maternal and child health issues like low birth weight, malnutrition and high-risk pregnancy under the RMNCAH+N program through various effective interventions. Future research should evaluate the feasibility of collaborative activities between RMNCAH+N program and the UNICEF in India.