bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between body weight change and incidence of major depressive disorder in patients with type 2 diabetes mellitus: a nationwide longitudinal follow-up cohort study of 1.1 million
Authors: Kim Eun Young , Lee You-Bin , Lee Gyu-Na , Han Kyungdo , Jeong Su-Min 
Published: March 2024

AbstractBackgroundComorbid depression substantially affects the management of glycemia and diabetes-related complications among patients with type 2 diabetes mellitus. In this study, we sought to determine the association between weight change over 4 years and depression risk among patients with type 2 diabetes mellitus.MethodsThis population-based retrospective cohort study from the National Health Insurance Services of Korea included 1 111 345 patients with type 2 diabetes who were divided into groups according to body weight change over 4 years. Body weight changes were compared with the preceding 4-year period (2005–2008). Depression was defined according to the International Classification of Diseases 10th revision code for depression (F32 and F33) on one or more inpatient or outpatient claims.ResultsDuring a median follow-up of 7.4 years, 244 081 cases of depression were identified. We observed a U-shaped association between body weight change and depression risk with a higher risk among both groups of weight loss (hazard ratio (HR) 1.17, 95% CI 1.15–1.19 for ⩾ −10%; HR 1.07, 95% CI 1.06–1.08 for −10 to −5%) and weight gain (HR 1.06, 95% CI 1.04–1.08 for ⩾10%; HR 1.02, 95% CI 1.01–1.04 for 5–10%) compared with the stable weight group (−5 to 5%).ConclusionsA U-shaped association between body weight change and depression risk was observed in this large nationwide cohort study. Our study suggests that patients with type 2 diabetes and weight change, either gain or loss, could be considered a high-risk group for depression.
Retinal microvascular function and incidence and trajectories of clinically relevant depressive symptoms: the Maastricht Study
Authors: van Gennip April C. E. , Gupta Monideepa D. , Houben Alfons J. H. M. , Berendschot Tos T. J. M. , Webers Carroll A. B. , van Greevenbroek Marleen M. J. , van der Kallen Carla J. H. , Koster Annemarie , Wesselius Anke , Eussen Simone J. P. M. , Schalkwijk Casper G. , de Galan Bastiaan E. , Köhler Sebastian , Schram Miranda T. , Stehouwer Coen D. A. , van Sloten Thomas T. 
Published: March 2024

AbstractBackgroundCerebral microvascular dysfunction may contribute to depression via disruption of brain structures involved in mood regulation, but evidence is limited. We investigated the association of retinal microvascular function, a proxy for microvascular function in the brain, with incidence and trajectories of clinically relevant depressive symptoms.MethodsLongitudinal data are from The Maastricht Study of 5952 participants (59.9 ± 8.5 years/49.7% women) without clinically relevant depressive symptoms at baseline (2010–2017). Central retinal arteriolar equivalent and central retinal venular equivalent (CRAE and CRVE) and a composite score of flicker light-induced retinal arteriolar and venular dilation were assessed at baseline. We assessed incidence and trajectories of clinically relevant depressive symptoms (9-item Patient Health Questionnaire score ⩾10). Trajectories included continuously low prevalence (low, n = 5225 [87.8%]); early increasing, then chronic high prevalence (early-chronic, n = 157 [2.6%]); low, then increasing prevalence (late-increasing, n = 247 [4.2%]); and remitting prevalence (remitting, n = 323 [5.4%]).ResultsAfter a median follow-up of 7.0 years (range 1.0–11.0), 806 (13.5%) individuals had incident clinically relevant depressive symptoms. After full adjustment, a larger CRAE and CRVE were each associated with a lower risk of clinically relevant depressive symptoms (hazard ratios [HRs] per standard deviation [s.d.]: 0.89 [95% confidence interval (CI) 0.83–0.96] and 0.93 [0.86–0.99], respectively), while a lower flicker light-induced retinal dilation was associated with a higher risk of clinically relevant depressive symptoms (HR per s.d.: 1.10 [1.01–1.20]). Compared to the low trajectory, a larger CRAE was associated with lower odds of belonging to the early-chronic trajectory (OR: 0.83 [0.69–0.99]) and a lower flicker light-induced retinal dilation was associated with higher odds of belonging to the remitting trajectory (OR: 1.23 [1.07–1.43]).ConclusionsThese findings support the hypothesis that cerebral microvascular dysfunction contributes to the development of depressive symptoms.
Understanding sustained adoption of conservation agriculture among smallholder farmers: insights from a sentinel site in Malawi
Authors: Pangapanga-Phiri Innocent , Ngoma Hambulo , Thierfelder Christian 
Published: March 2024

Abstract
Smallholder farming systems need climate-proofing and sustainable intensification practices such as conservation agriculture (CA), are promising options. However, there is a general perception that the adoption of CA systems in southern Africa is low. Sentinel sites, where CA has been promoted for a long time, offer forward-looking new insights. This paper, thus, takes a deep dive at Nkhotakota district of Malawi to understand what could have led to the success of CA promotion and subsequent perceived high adoption. We use survey data from 620 farmers, with 298 farmers sampled from treatment areas – known to have had contact with host farmers and 320 from a control group. Overall, 31% of the farmers in both groups adopted full CA over at least a 2-year period. We also find that about 57% of farmers in the treatment area adopted full CA and only 7% of farmers in the control areas. This highlights that longer-term CA promotion with dedicated extension support can enhance the uptake of CA practices. In essence, this paper offers a different perspective to the current narrative that CA systems are too complex and knowledge intensive to be adopted despite its long-term promotion and significant investments. However, there are some nuances: sustained adoption even in sentinel sites is neither 100% nor persistent over the long term. We find an appreciable adoption decay, showing large declines from highs of 57 and 7% in adoption for at least 2 years for treatment and control, respectively, to 12% in the treatment group and practically zero in the control when we condition full CA adoption to at least 7 years. This means that fewer farmers adopted CA for a longer period and suggests some dis-adoption over time even in sentinel sites. The key adoption enablers in the sentinel sites include the availability of training, dedicated longer-term extension support coupled with farmer experiential learning through demonstration plots managed by host farmers. Based on our findings, there is need to consistently promote CA using farmer-centric approaches that include peer-to-peer learning over long periods. This allows farmers time to experiment with different CA options, enable behavioral and lasting change. At policy level, there is need to build and strengthen farmer groups to facilitate easier access to inputs like leguminous crop seeds for farmers practicing CA and to offer market-smart incentives to induce initial adoption in the short term to facilitate sustained adoption.
Power and alterity: Depictions of the Vascones from antiquity to the middle ages
Authors: Aguirresarobe Asier H. 
Published: March 2024

AbstractThis article undertakes an examination of the origins and evolution of a discourse of alterity against the Vascones –the alleged forefathers of the Basques – and other Western Pyrenean peoples from Antiquity to the Middle Ages. The methodology employed involves the study of literary references made to these peoples, which are then compared to recent scholarly and archeological evidence. Through this analysis, it becomes possible to evaluate the accuracy of these mentions and interpret them within their specific historical context. The results of this research indicate that mentions of the Vascones during this timeframe were mainly polemic in nature and lacked substantial grounding in empirical reality. Instead, it seems that the underlying objective of these narratives of alterity was twofold: to enhance the social and political standing of their authors and to support their claims to political control over the Western Pyrenees. The abandonment of these interpretative repertoires during the tenth century, coinciding with the emergence of the kingdom of Pamplona and the county-duchy of Wasconia, further emphasizes the connection between the display of these tropes and imbalances in political power between the region and its neighbors. The conclusions of this article directly challenge the underpinnings of discourses that depict the ancient Vascones as entirely alien to the political and religious paradigms derived from the Roman and Christian traditions. In so doing, it thus confront narratives about these “ancient Basques” that are prevalent in contemporary Basque cultural production.
Atypical Seasonality of the Silicon Cycle in the Yellow River Estuary and Bohai Sea Revealed by Stable Silicon Isotopes
Authors: Cui Quanchao , Liu Xiaowen , Wang Zhenyan , Sun Weidong , Xiao Yuanyuan , Sun Xiaole 
Published: March 2024

AbstractBiogeochemical Si cycle in coastal areas is of vital importance due to its close link with the carbon cycle. However, the coastal Si cycle has been heavily perturbated by human activities. In this study, we studied the spatiotemporal distribution of biogenic Si (BSi) and dissolved Si (DSi) combined with stable Si isotopes of DSi (δ30SiDSi) in the Yellow River estuary and Bohai Sea, one of the most populated coastal areas in the world. Over an annual cycle, BSi and DSi concentrations varied from 0 to 43.5 μmol L−1 and from 0.3 to 40 μmol L−1, respectively. This was associated with large δ30SiDSi variations from +0.49 ± 0.22‰ (2sd) in spring to +2.92 ± 0.14‰ in winter, which opposed to observations that summer δ30SiDSi values were usually higher than those in winter. This atypical variation could be attributed to the water‐sediment regulation on the Yellow River occurring every early summer, leading to a strong water mixing pattern and suppressing diatom production in summer. This mixing was further prolonged by extreme autumn rainfall on land. The pulse supply of nutrients subsequently enhanced primary productivity from autumn through winter. In spring, the resuspended seafloor sediments were likely an important DSi source with δ30Si values of <−0.5‰. Our findings suggest that natural Si seasonality has been greatly masked by human activities and climate events in the Bohai Sea. Our study serves as a reference of the Si cycle research endeavors worldwide for revealing the overlaying effect of anthropogenic consequences and natural variability.
Chemistry, Growth, and Fate of the Unique, Short‐Lived (2019–2020) Water Lake at the Summit of Kīlauea Volcano, Hawaii
Authors: Nadeau P. A. , Hurwitz S. , Peek S. , Lerner A. H. , Younger E. F. , Patrick M. R. , Damby D. E. , McCleskey R. B. , Kelly P. J. 
Published: March 2024

AbstractLess than a year after the 2018 Kīlauea caldera collapse and eruption, water appeared in newly deepened Halemaʻumaʻu crater. The lake—unprecedented in the written record—grew to a depth of ∼50 m before lava from the December 2020 eruption boiled it away. Surface water heightened concerns of potential phreatic or phreatomagmatic explosions but also offered a new means of possibly identifying eruption precursors. The U.S. Geological Survey Hawaiian Volcano Observatory (HVO) monitored the lake via direct visual observation, webcams, thermal imaging, colorimetry, and laser rangefinders. HVO also employed uncrewed aircraft systems to sample the water and measure near‐lake gas composition. The lake's δD and δ18O indicate a groundwater source with substantial evaporation. The initial sample had a salinity (total dissolved solids concentration) of 71,000 mg/L and was rich in sulfate (∼53,000 mg/L), iron (∼500 mg/L), and magnesium (∼10,000 mg/L). Subsequent samples were slightly more dilute. The water's pH (∼4), δ34S (+4.3‰), and surface temperatures (up to 85°C) suggest, rather than significant scrubbing of magmatic volatiles, leaching of basalt and reactions with sulfate minerals resulted in high concentrations of sulfate and other solutes. Thermodynamic modeling and precipitate mineralogy indicate that water composition was controlled by iron oxidation and sulfate dissolution. Although the lake exhibited no detectable precursors before the next eruption, and phreatic or phreatomagmatic explosions did not materialize, our multi‐parameter approach to monitoring yielded an enhanced understanding of the hydrologic, geologic, and magmatic conditions that led to the formation of the unique and short‐lived lake.
Hybrid Theory‐Guided Data Driven Framework for Calculating Irrigation Water Use of Three Staple Cereal Crops in China
Authors: Bo Yong , Li Xueke , Liu Kai , Wang Shudong , Li Dehui , Xu Yu , Wang Mengmeng 
Published: March 2024

AbstractCurrent irrigation water use (IWU) estimation methods confront uncertainties warranting further attention, primarily stemming from constraints within model structure and data quality. This study proposes a hybrid framework that integrates multiple machine learning (ML) methods with theory‐guided strategies to calculate IWU for three principal cereal crops within the Chinese agricultural landscape. We generated high resolution time series data sets of evapotranspiration and surface soil moisture (SM) using remote sensing resources. ML techniques, along with the Bayesian three‐cornered hat ensemble, were employed to drive multiple remote sensing‐derived data sets in IWU calculation. We applied two theory‐guided mechanisms to quantify irrigation signals: first, converting original SM values into logarithmic terms, and second, extracting process‐based SM residuals. Proposed framework has been validated at 12 field stations across China, yielding coefficient of determination (R2) ranging from 0.54 to 0.70, and root mean square error (RMSE) spanning 278–335 mm/yr. Our framework demonstrates considerable strength in IWU estimation when compared to reported IWU values form 341 cities across China. Specifically, for rice, wheat, and maize, the R2 values range from 0.78 to 0.83, 0.68 to 0.76, and 0.53 to 0.64, respectively, with corresponding RMSE measuring 0.22–0.25, 0.10–0.12, and 0.11–0.13 km3/yr, respectively. These findings highlight the effectiveness of theory‐guided strategies in discerning irrigation‐related information, thereby improving overall model performance. Attention should be directed toward the uncertainties in evapotranspiration and precipitation products on model performance, which remained modest, with a relative change of less than 5%.
The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair
Authors: Kang Heeseog , Strong Amy L. , Sun Yuxiao , Guo Lei , Juan Conan , Bancroft Alec C. , Choi Ji Hae , Pagani Chase A. , Fernandes Aysel A. , Woodard Michael , Lee Juhoon , Ramesh Sowmya , James Aaron W. , Hudson David , Dalby Kevin N. , Xu Lin , Tower Robert J. , Levi Benjamin 
Published: March 2024

AbstractWhile hypoxic signaling has been shown to play a role in many cellular processes, its role in metabolism-linked extracellular matrix (ECM) organization and downstream processes of cell fate after musculoskeletal injury remains to be determined. Heterotopic ossification (HO) is a debilitating condition where abnormal bone formation occurs within extra-skeletal tissues. Hypoxia and hypoxia-inducible factor 1α (HIF-1α) activation have been shown to promote HO. However, the underlying molecular mechanisms by which the HIF-1α pathway in mesenchymal progenitor cells (MPCs) contributes to pathologic bone formation remain to be elucidated. Here, we used a proven mouse injury-induced HO model to investigate the role of HIF-1α on aberrant cell fate. Using single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics analyses of the HO site, we found that collagen ECM organization is the most highly up-regulated biological process in MPCs. Zeugopod mesenchymal cell-specific deletion of Hif1α (Hoxa11-CreERT2; Hif1afl/fl) significantly mitigated HO in vivo. ScRNA-seq analysis of these Hoxa11-CreERT2; Hif1afl/fl mice identified the PLOD2/LOX pathway for collagen cross-linking as downstream of the HIF-1α regulation of HO. Importantly, our scRNA-seq data and mechanistic studies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α deletion. From a translational aspect, a pan-LOX inhibitor significantly decreased HO. A newly screened compound revealed that the inhibition of PLOD2 activity in MPCs significantly decreased osteogenic differentiation and glycolytic metabolism. This suggests that the HIF-1α/PLOD2/LOX axis linked to metabolism regulates HO-forming MPC fate. These results suggest that the HIF-1α/PLOD2/LOX pathway represents a promising strategy to mitigate HO formation.
RNA expression of 6 genes from metastatic mucosal gastric cancer serves as the global prognostic marker for gastric cancer with functional validation
Authors: Suh Yun-Suhk , Lee Jieun , George Joshy , Seol Donghyeok , Jeong Kyoungyun , Oh Seung-Young , Bang Chanmi , Jun Yukyung , Kong Seong-Ho , Lee Hyuk-Joon , Kim Jong-Il , Kim Woo Ho , Yang Han-Kwang , Lee Charles 
Published: March 2024

Abstract
Background
Molecular analysis of advanced tumors can increase tumor heterogeneity and selection bias. We developed a robust prognostic signature for gastric cancer by comparing RNA expression between very rare early gastric cancers invading only mucosal layer (mEGCs) with lymph node metastasis (Npos) and those without metastasis (Nneg).

Methods
Out of 1003 mEGCs, all Npos were matched to Nneg using propensity scores. Machine learning approach comparing Npos and Nneg was used to develop prognostic signature. The function and robustness of prognostic signature was validated using cell lines and external datasets.

Results
Extensive machine learning with cross-validation identified the prognostic classifier consisting of four overexpressed genes (HDAC5, NPM1, DTX3, and PPP3R1) and two downregulated genes (MED12 and TP53), and enabled us to develop the risk score predicting poor prognosis. Cell lines engineered to high-risk score showed increased invasion, migration, and resistance to 5-FU and Oxaliplatin but maintained sensitivity to an HDAC inhibitor. Mouse models after tail vein injection of cell lines with high-risk score revealed increased metastasis. In three external cohorts, our risk score was identified as the independent prognostic factor for overall and recurrence-free survival.

Conclusion
The risk score from the 6-gene classifier can successfully predict the prognosis of gastric cancer.
Suppression of apoptosis impairs phalangeal joint formation in the pathogenesis of brachydactyly type A1
Authors: Leung Adrian On Wah , Poon Andrew Chung Hin , Wang Xue , Feng Chen , Chen Peikai , Zheng Zhengfan , To Michael KaiTsun , Chan Wilson Cheuk Wing , Cheung Martin , Chan Danny 
Published: March 2024

AbstractApoptosis occurs during development when a separation of tissues is needed. Synovial joint formation is initiated at the presumptive site (interzone) within a cartilage anlagen, with changes in cellular differentiation leading to cavitation and tissue separation. Apoptosis has been detected in phalangeal joints during development, but its role and regulation have not been defined. Here, we use a mouse model of brachydactyly type A1 (BDA1) with an IhhE95K mutation, to show that a missing middle phalangeal bone is due to the failure of the developing joint to cavitate, associated with reduced apoptosis, and a joint is not formed. We showed an intricate relationship between IHH and interacting partners, CDON and GAS1, in the interzone that regulates apoptosis. We propose a model in which CDON/GAS1 may act as dependence receptors in this context. Normally, the IHH level is low at the center of the interzone, enabling the “ligand-free” CDON/GAS1 to activate cell death for cavitation. In BDA1, a high concentration of IHH suppresses apoptosis. Our findings provided new insights into the role of IHH and CDON in joint formation, with relevance to hedgehog signaling in developmental biology and diseases.
Speaking without vocal folds using a machine-learning-assisted wearable sensing-actuation system
Authors: Che Ziyuan , Wan Xiao , Xu Jing , Duan Chrystal , Zheng Tianqi , Chen Jun 
Published: March 2024

AbstractVoice disorders resulting from various pathological vocal fold conditions or postoperative recovery of laryngeal cancer surgeries, are common causes of dysphonia. Here, we present a self-powered wearable sensing-actuation system based on soft magnetoelasticity that enables assisted speaking without relying on the vocal folds. It holds a lightweighted mass of approximately 7.2 g, skin-alike modulus of 7.83 × 105 Pa, stability against skin perspiration, and a maximum stretchability of 164%. The wearable sensing component can effectively capture extrinsic laryngeal muscle movement and convert them into high-fidelity and analyzable electrical signals, which can be translated into speech signals with the assistance of machine learning algorithms with an accuracy of 94.68%. Then, with the wearable actuation component, the speech could be expressed as voice signals while circumventing vocal fold vibration. We expect this approach could facilitate the restoration of normal voice function and significantly enhance the quality of life for patients with dysfunctional vocal folds.
Policy and market forces delay real estate price declines on the US coast
Authors: McNamara Dylan E. , Smith Martin D. , Williams Zachary , Gopalakrishnan Sathya , Landry Craig E. 
Published: March 2024

AbstractDespite increasing risks from sea-level rise (SLR) and storms, US coastal communities continue to attract relatively high-income residents, and coastal property values continue to rise. To understand this seeming paradox and explore policy responses, we develop the Coastal Home Ownership Model (C-HOM) and analyze the long-term evolution of coastal real estate markets. C-HOM incorporates changing physical attributes of the coast, economic values of these attributes, and dynamic risks associated with storms and flooding. Resident owners, renters, and non-resident investors jointly determine coastal property values and the policy choices that influence the physical evolution of the coast. In the coupled system, we find that subsidies for coastal management, such as beach nourishment, tax advantages for high-income property owners, and stable or increasing property values outside the coastal zone all dampen the effects of SLR on coastal property values. The effects, however, are temporary and only delay precipitous declines as total inundation approaches. By removing subsidies, prices would more accurately reflect risks from SLR but also trigger more coastal gentrification, as relatively high-income owners enter the market and self-finance nourishment. Our results suggest a policy tradeoff between slowing demographic transitions in coastal communities and allowing property markets to adjust smoothly to risks from climate change.