bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ice volume and thickness of all Scandinavian glaciers and ice caps
Authors: Frank Thomas , van Pelt Ward Jan Jacobus 
Published: March 2024

Abstract
We present a new map of bed topography and ice thickness together with a corresponding ice volume estimate representative of the years ~2010 for all Scandinavian ice caps and glaciers. Starting from surface observations, we invert for ice thickness by iteratively running an innovative ice dynamics model on a distributed grid and updating bed topography until modelled and observed glacier dynamics as represented by their rate of surface elevation change (dh/dt) fields align. The ice flow model used is the instructed glacier model (Jouvet and Cordonnier, 2023, Journal of Glaciology 1–15), a generic physics-informed deep-learning emulator that models higher-order ice flow with high-computational efficiency. We calibrate the modelled thicknesses against >11 000 ice thickness observations, resulting in a final ice volume estimate of 302.7 km3 for Norway, 18.4 km3 for Sweden and 321.1 km3 for the whole of Scandinavia with an error estimate of ~

$\pm 11\%$

. The validation statistics computed indicate good agreement between modelled and observed thicknesses (RMSE = 55 m, Pearson's r = 0.87, bias = 0.8 m), outperforming all other ice thickness maps available for the region. The modelled bed shapes thus provide unprecedented detail in the subglacial topography, especially for ice caps where we produce the first maps that show ice-dynamically realistic flow features.
Beyond the “Historiographical Monroe Doctrine”: The Latin American Left and the World
Authors: Chase Michelle 
Published: March 2024

This essay reviews the following works:Latin America and the Global Cold War. Edited by Thomas C. Field Jr., Stella Krepp, and Vanni Pettinà. Chapel Hill: University of North Carolina Press, 2020. Pp. 440. $42.50 hardcover, $29.99 e-book. ISBN: 9781469655697.La imagen tricontinental: La feminidad, el Che Guevara, y el imperialismo a través del arte gráfico de la OSPAAAL. By Alberto García Molinero. Santiago de Chile: Ariadna Ediciones, 2022. Open access: http://ariadnaediciones.cl/images/pdf/LaImagenTricontinental.pdf.From the Tricontinental to the Global South: Race, Radicalism, and Transnational Solidarity. By Anne Garland Mahler. Durham, NC: Duke University Press, 2018. Pp. xi + 347. $28.95 paperback. ISBN: 9780822371250.Toward a Global History of Latin America’s Revolutionary Left. Edited by Tanya Harmer and Alberto Martín Álvarez. Gainesville: University Press of Florida, 2021. Pp. xi + 301. $90.00 hardcover. ISBN: 9781683401698.No Barrier Can Contain It: Cuban Antifascism and the Spanish Civil War. By Ariel Mae Lambe. Chapel Hill: University of North Carolina Press, 2019. Pp. xvi + 310. $37.50 paperback. ISBN: 9781469652856.The Tricontinental Revolution: Third World Radicalism and the Cold War. Edited by R. Joseph Parrott and Mark Atwood Lawrence. Cambridge: Cambridge University Press, 2022. Pp. xvii + 365. $120.00 hardcover. ISBN: 9781316519110.South-South Solidarity and the Latin American Left. By Jessica Stites Mor. Madison: University of Wisconsin Press, 2022. Pp. xix + 266. $79.95 hardcover. ISBN: 9780299336103.Revolution in Development: Mexico and the Governance of the Global Economy. By Christy Thornton. Oakland: University of California Press, 2021. Pp. 301. $29.95 paperback. ISBN: 9780520297166.
Refugee Protection through Safeguarding Intangible Cultural Heritage of the Home Country and Refugee Journey
Authors: Al Shallah Sherine 
Published: March 2024

AbstractThe legal literature on refugee cultural heritage is limited, and cultural rights are part of the law that appropriately addresses refugee cultural heritage issues. Cultural heritage is integral to the definition of refugees; refugee protection must include safeguarding refugee cultural heritage.1 This Article reviews international law around refugees’ intangible cultural heritage, which incorporates refugee relationships with their tangible cultural heritage.2 It also frames the discussion around refugee intangible cultural heritage in a holistic paradigm that consolidates “refugee home heritage” (refugee intangible cultural heritage of home country) and “refuge heritage” (refugee intangible cultural heritage of refugee journey from persecution or conflict to resettlement or return). The Article finds that, whereas the international law framework lays the groundwork for such a holistic paradigm, international and national laws and state policy approaches must be reformed to achieve refugee protection in line with international obligations.
Childhood unpredictability research within the developmental psychopathology framework: Advances, implications, and future directions
Authors: Doom Jenalee R. , Han Deborah , Rivera Kenia M. , Tseten Tenzin 
Published: March 2024

AbstractGreater unpredictability in childhood from the level of the caregiver-child dyad to broader family, home, or environmental instability is consistently associated with disruptions in cognitive, socioemotional, behavioral, and biological development in humans. These findings are bolstered by experimental research in non-human animal models suggesting that early life unpredictability is an important environmental signal to the developing organism that shapes neurodevelopment and behavior. Research on childhood unpredictability has surged in the past several years, guided in part by theoretical grounding from the developmental psychopathology framework (shaped largely by Dr. Dante Cicchetti’s innovative work). The current review focuses on future directions for unpredictability research, including probing intergenerational effects, the role of predictability in resilience, cultural and contextual considerations, and novel developmental outcomes that should be tested in relation to childhood unpredictability. We urge the integration of multidisciplinary perspectives and collaborations into future research on unpredictability. We also provide ideas for translating this research to real-world practice and policy and encourage high-quality research testing whether incorporating predictability into interventions and policy improves developmental outcomes, which would support further dissemination of these findings.
Modified Senning procedure in a patient with dextrocardia with left atrial isomerism and anomalous systemic venous drainage: a rare case report
Authors: Munshi Sayar Kumar , Jones Caroline , Dhannapuneni Ramana 
Published: March 2024

AbstractThe atrial switch procedure by Senning or Mustard technique primarily aims in correcting parallel systemic and pulmonary circulations at atrial level. This procedure may be used in late presenting D-transposition of great arteries with a deconditioned left ventricle, congenitally corrected transposition of great arteries and isolated ventricular inversion. We describe the case of a child with dextrocardia, left atrial isomerism with complex pulmonary and systemic venous drainage resulting in mixing at atrial level. She was successfully operated by modified Senning procedure performed through the left-sided atrium.
Ionospheric TEC Prediction Based on Ensemble Learning Models
Authors: Zhou Yang , Liu Jing , Li Shuhan , Li Qiaoling 
Published: March 2024

AbstractIn this paper, we propose the usage of an ensemble learning approach for predicting total electron content (TEC). The training data set spans from 2007 to 2016, while the testing data set is set to the year 2017. The model inputs in our study included Solar radio flux (F107), Solar Wind plasma speed, By, Bz, Dst, Ap, AE, day of year, universal time, 30‐day and 90‐day TEC averages. Specifically, eXtreme Gradient Boosting (XGBoost), Gradient Boosting Decision Tree, and Decision Tree were utilized for 1‐hr TEC prediction at high‐ (80°W, 80°N), mid‐ (80°W, 40°N), and low‐ latitudes (80°W, 10°N). Results indicate that all three models performed well in predicting TEC, with a mean error of only approximately 0.6 TECU at high‐ and mid‐ latitudes and 1.13 TECU at low latitudes. At the same time, we compared the model with 1‐day Beijing University of Aeronautics and Astronautics model during the period of magnetic storm from 25 August 2018 to 27 August 2018 and a quiet period from 13 December 2018 to 15 December 2018. In the magnetic storm period, Our model showed an average reduction of 1.83 TECU compared to BUAA model. During the quiet period, XGBoost exhibit an average error that is 1.14 TECU lower than that of BUAA model. Moreover, TEC prediction over the region between the 20°N–45°N and 70°E−120°E during geomagnetic storm has an error of 2.74 TECU, showing the stability and superiority of XGBoost. Overall, the ensemble learning approach exhibits its advantage in predicting TEC.
Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety
Authors: Rohn Troy T. , Radin Dean , Brandmeyer Tracy , Seidler Peter G. , Linder Barry J. , Lytle Tom , Mee John L. , Macciardi Fabio 
Published: March 2024

AbstractShort-hairpin RNAs (shRNA), targeting knockdown of specific genes, hold enormous promise for precision-based therapeutics to treat numerous neurodegenerative disorders. However, whether shRNA constructed molecules can modify neuronal circuits underlying certain behaviors has not been explored. We designed shRNA to knockdown the human HTR2A gene in vitro using iPSC-differentiated neurons. Multi-electrode array (MEA) results showed that the knockdown of the 5HT-2A mRNA and receptor protein led to a decrease in spontaneous electrical activity. In vivo, intranasal delivery of AAV9 vectors containing shRNA resulted in a decrease in anxiety-like behavior in mice and a significant improvement in memory in both mice (104%) and rats (92%) compared to vehicle-treated animals. Our demonstration of a non-invasive shRNA delivery platform that can bypass the blood–brain barrier has broad implications for treating numerous neurological mental disorders. Specifically, targeting the HTR2A gene presents a novel therapeutic approach for treating chronic anxiety and age-related cognitive decline.
Mitochondria-associated endoplasmic reticulum membrane (MAM): a dark horse for diabetic cardiomyopathy treatment
Authors: Liu Yong , Huo Jin-Ling , Ren Kaidi , Pan Shaokang , Liu Hengdao , Zheng Yifeng , Chen Jingfang , Qiao Yingjin , Yang Yang , Feng Qi 
Published: March 2024

AbstractDiabetic cardiomyopathy (DCM), an important complication of diabetes mellitus (DM), is one of the most serious chronic heart diseases and has become a major cause of heart failure worldwide. At present, the pathogenesis of DCM is unclear, and there is still a lack of effective therapeutics. Previous studies have shown that the homeostasis of mitochondria and the endoplasmic reticulum (ER) play a core role in maintaining cardiovascular function, and structural and functional abnormalities in these organelles seriously impact the occurrence and development of various cardiovascular diseases, including DCM. The interplay between mitochondria and the ER is mediated by the mitochondria-associated ER membrane (MAM), which participates in regulating energy metabolism, calcium homeostasis, mitochondrial dynamics, autophagy, ER stress, inflammation, and other cellular processes. Recent studies have proven that MAM is closely related to the initiation and progression of DCM. In this study, we aim to summarize the recent research progress on MAM, elaborate on the key role of MAM in DCM, and discuss the potential of MAM as an important therapeutic target for DCM, thereby providing a theoretical reference for basic and clinical studies of DCM treatment.
Strong positive selection biases identity-by-descent-based inferences of recent demography and population structure in Plasmodium falciparum
Authors: Guo Bing , Borda Victor , Laboulaye Roland , Spring Michele D. , Wojnarski Mariusz , Vesely Brian A. , Silva Joana C. , Waters Norman C. , O’Connor Timothy D. , Takala-Harrison Shannon 
Published: March 2024

AbstractMalaria genomic surveillance often estimates parasite genetic relatedness using metrics such as Identity-By-Decent (IBD), yet strong positive selection stemming from antimalarial drug resistance or other interventions may bias IBD-based estimates. In this study, we use simulations, a true IBD inference algorithm, and empirical data sets from different malaria transmission settings to investigate the extent of this bias and explore potential correction strategies. We analyze whole genome sequence data generated from 640 new and 3089 publicly available Plasmodium falciparum clinical isolates. We demonstrate that positive selection distorts IBD distributions, leading to underestimated effective population size and blurred population structure. Additionally, we discover that the removal of IBD peak regions partially restores the accuracy of IBD-based inferences, with this effect contingent on the population’s background genetic relatedness and extent of inbreeding. Consequently, we advocate for selection correction for parasite populations undergoing strong, recent positive selection, particularly in high malaria transmission settings.
Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia
Authors: Funes Salome , Jung Jonathan , Gadd Del Hayden , Mosqueda Michelle , Zhong Jianjun , Shankaracharya  , Unger Matthew , Stallworth Karly , Cameron Debra , Rotunno Melissa S. , Dawes Pepper , Fowler-Magaw Megan , Keagle Pamela J. , McDonough Justin A. , Boopathy Sivakumar , Sena-Esteves Miguel , Nickerson Jeffrey A. , Lutz Cathleen , Skarnes William C. , Lim Elaine T. , Schafer Dorothy P. , Massi Francesca , Landers John E. , Bosco Daryl A. 
Published: March 2024

AbstractMicroglia play a pivotal role in neurodegenerative disease pathogenesis, but the mechanisms underlying microglia dysfunction and toxicity remain to be elucidated. To investigate the effect of neurodegenerative disease-linked genes on the intrinsic properties of microglia, we studied microglia-like cells derived from human induced pluripotent stem cells (iPSCs), termed iMGs, harboring mutations in profilin-1 (PFN1) that are causative for amyotrophic lateral sclerosis (ALS). ALS-PFN1 iMGs exhibited evidence of lipid dysmetabolism, autophagy dysregulation and deficient phagocytosis, a canonical microglia function. Mutant PFN1 also displayed enhanced binding affinity for PI3P, a critical signaling molecule involved in autophagic and endocytic processing. Our cumulative data implicate a gain-of-toxic function for mutant PFN1 within the autophagic and endo-lysosomal pathways, as administration of rapamycin rescued phagocytic dysfunction in ALS-PFN1 iMGs. These outcomes demonstrate the utility of iMGs for neurodegenerative disease research and implicate microglial vesicular degradation pathways in the pathogenesis of these disorders.
Artificial cells for in vivo biomedical applications through red blood cell biomimicry
Authors: Waeterschoot Jorik , Gosselé Willemien , Lemež Špela , Casadevall i Solvas Xavier 
Published: March 2024

AbstractRecent research in artificial cell production holds promise for the development of delivery agents with therapeutic effects akin to real cells. To succeed in these applications, these systems need to survive the circulatory conditions. In this review we present strategies that, inspired by the endurance of red blood cells, have enhanced the viability of large, cell-like vehicles for in vivo therapeutic use, particularly focusing on giant unilamellar vesicles. Insights from red blood cells can guide modifications that could transform these platforms into advanced drug delivery vehicles, showcasing biomimicry’s potential in shaping the future of therapeutic applications.
Elevation-dependent pattern of net CO2 uptake across China
Authors: Wei Da , Tao Jing , Wang Zhuangzhuang , Zhao Hui , Zhao Wei , Wang Xiaodan 
Published: March 2024

AbstractThe elevation gradient has long been known to be vital in shaping the structure and function of terrestrial ecosystems, but little is known about the elevation-dependent pattern of net CO2 uptake, denoted by net ecosystem productivity (NEP). Here, by analyzing data from 203 eddy covariance sites across China, we report a negative linear elevation-dependent pattern of NEP, collectively shaped by varying hydrothermal factors, nutrient supply, and ecosystem types. Furthermore, the NEP shows a higher temperature sensitivity in high-elevation environments (3000–5000 m) compared with the lower-elevation environments (<3000 m). Model ensemble and satellite-based observations consistently reveal more rapid relative changes in NEP in high-elevation environments during the last four decades. Machine learning also predicts a stronger relative increase in high-elevation environments, whereas less change is expected at lower elevations. We therefore conclude a varying elevation-dependent pattern of the NEP of terrestrial ecosystems in China, although there is significant uncertainty involved.
Metabolic profiles outperform the microbiota in assessing the response of vaginal microenvironments to the changed state of HPV infection
Authors: Dai Wenkui , Du Hui , Zhou Qian , Li Sumei , Wang Yinan , Hou Jun , Guo Chunlei , Yang Qing , Li Changzhong , Xie Shouxia , Li Shuai Cheng , Wu Ruifang 
Published: March 2024

AbstractThere is a deficiency in population-based studies investigating the impact of HPV infection on vaginal microenvironment, which influences the risk of persistent HPV infection. This prospective study aimed to unravel the dynamics of vaginal microbiota (VM) and vaginal metabolome in reaction to the changed state of HPV infection. Our results propose that the vaginal metabolome may be a superior indicator to VM when assessing the impact of altered HPV state on the vaginal microenvironment.
Reporting on invasive lobular breast cancer in clinical trials: a systematic review
Authors: Van Baelen Karen , Van Cauwenberge Josephine , Maetens Marion , Beck Gabriela , Camden Ann , Chase Megan-Claire , Fraser Valerie , Freeney Siobhan , Hutcheson Laurie , Levine Julia K. , Lien Tone , Terveer Rian , Turner Claire , Senkus Elzbieta , Jankowitz Rachel C. , Vandecaveye Vincent , Floris Giuseppe , Neven Patrick , Wildiers Hans , Sawyer Elinor , Vincent-Salomon Anne , Derksen Patrick W. B. , Desmedt Christine 
Published: March 2024

AbstractInvasive lobular breast cancer (ILC) differs from invasive breast cancer of no special type in many ways. Evidence on treatment efficacy for ILC is, however, lacking. We studied the degree of documentation and representation of ILC in phase III/IV clinical trials for novel breast cancer treatments. Trials were identified on Pubmed and clinicaltrials.gov. Inclusion/exclusion criteria were reviewed for requirements on histological subtype and tumor measurability. Documentation of ILC was assessed and ILC inclusion rate, central pathology and subgroup analyses were evaluated. Inclusion restrictions concerning tumor measurability were found in 39/93 manuscripts. Inclusion rates for ILC were documented in 13/93 manuscripts and varied between 2.0 and 26.0%. No central pathology for ILC was reported and 3/13 manuscripts had ILC sub-analyses. ILC is largely disregarded in most trials with poor representation and documentation. The current inclusion criteria using RECIST v1.1, fall short in recognizing the unique non-measurable metastatic infiltration of ILC.
Cryogenic propellant management in space: open challenges and perspectives
Authors: Simonini Alessia , Dreyer Michael , Urbano Annafederica , Sanfedino Francesco , Himeno Takehiro , Behruzi Philipp , Avila Marc , Pinho Jorge , Peveroni Laura , Gouriet Jean-Baptiste 
Published: March 2024

AbstractThis paper presents open challenges and perspectives of propellant management for crewed deep space exploration. The most promising propellants are liquid hydrogen and liquid methane, together with liquid oxygen as an oxidizer. These fluids remain liquid only at cryogenic conditions, that is, at temperatures lower than 120 K. To extend the duration of space exploration missions, or even to enable them, the storage and refueling from a cryogenic on-orbit depot is necessary. We review reference missions, architectures, and technology demonstrators and explain the main operations that are considered as enablers for cryogenic storage and transfer. We summarize the state of the art for each of them, showing that many gaps in physical knowledge still need to be filled. This paper is based on recommendations originally proposed in a White Paper for ESA’s SciSpacE strategy.
Performance of castor oil polyurethane resin in composite with the piassava fibers residue from the Amazon
Authors: Rabelo Aparício Rosinaldo , Machado dos Santos Gabrielle , Siqueira Magalhães Rebelo Viviane , Mansanares Giacon Virgínia , Gomes da Silva Cristina 
Published: March 2024

AbstractThe use of castor oil in producing polyurethane resins has been identified as one of the most promising options for the industry. The piassava fibers waste generated by the industry on a large scale presents excellent properties as a reinforcing agent due to its high lignin content characterized by chemical tests and FTIR. Composite boards consisting of a higher content of mercerized piassava fibers (10 mm, 85 wt.%) reinforced polyurethane castor oil-based resin (prepolymer (PP) and polyol (OM)) exhibited excellent performance. Composites with these properties have strong potential for medium-density applications ranging from biomedical prosthetics to civil partition walls and insulation linings. Alkali treatment removed the superficial impurities of piassava fibers, activating polar groups, and physical characterization reported excellent performance for all composites. Among the composites, the CP3 sample (composite reinforced with piassava fibers (85 wt.% fibers; 1.2:1—PP:OM)) stood out with higher density and lower swelling and water absorption percentage than other composites. FTIR results indicated NCO traces after the resin cured in the PU3 (1.2:1—PP:OM), possibly contributing to the interaction with the fibers. DMA results reported relevant information about more flexibility to CP1 (composite reinforced with piassava fibers (85 wt.% fibers; 0.8:1—PP:OM)) and CP3 than CP2 (composite reinforced with piassava fibers (85 wt.% fibers; 1:1—PP:OM)). The results suggest that the proper combination with natural products must lead to composites with potential applications as engineering materials.