bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metastasis‐associated protein 1 participates in regulating luminal acidification of the epididymis via repressing estrogen receptor alpha transcription
Authors: Cheng Pang , Wei Jinhua , Liu Bo , Zhao Ya , Ma Binfang , Feng Xiao , Xiong Mingxiang , Zhao Jie , Shi Changhong , Li Zhen 
Published: March 2024

AbstractBackgroundAs a component of the nucleosome remodeling and deacetylating (NuRD) complex, metastasis‐associated protein 1 (MTA1) has been reported to be abundant in male reproductive system and might participate in spermatogenesis and sperm maturation, whereas the precise functional role of MTA1 in these processes is still undetermined.ObjectiveTo investigate the effect and potential function of MTA1 in male fertility.Materials and methodsMta1 knockout mice (Mta1−/−) were employed to detect their reproductive phenotype. The pH value of Mta1−/− epididymal luminal fluid was measured, and the potential mechanism of MTA1 involved in regulating luminal acidification was detected in vivo and in vitro. A vasectomy model with abnormal pH of epididymal lumen was established to further detect the effect of MTA1 on epididymal luminal microenvironment.ResultsMta1−/− mice were fertile without any detectable defects in spermatogenesis or sperm motility while the deficiency of MTA1 could acidify the initial segment of epididymis to a certain extent. MTA1 could interact with estrogen receptor alpha (ERα) and inhibit the transcription of ERα target gene, hydrogen exchanger 3 (NHE3), and ultimately affect the epididymal luminal milieu. After vasectomy, the Mta1−/− mice presented a more acidic epididymal lumen which was closer to the normal state compared to the wild‐type model.Discussion and conclusionMTA1 is dispensable for male fertility in mice, but plays a potentially important function in regulating luminal acidification of the epididymis.
Self‐determination theory and its implications for team motivation
Authors: Grenier Simon , Gagné Marylène , O'Neill Thomas 
Published: March 2024

AbstractDespite decades of research on teams, there are still gaps in our understanding of motivational dynamics within teams and the emergence of team‐level motivation. We advance a new team motivation model that invokes self‐determination theory (SDT), multilevel theory, emergence processes, and identity construction. Using the conceptualization of motivation offered by SDT, we define team motivation as a collective source of energy driving the direction, intensity, and persistence of team activities. By using SDT to develop the process‐based team motivation emergence model, we describe the role of human psychological needs that are involved in the emergence of this collective construct. An interpersonal feedback loop intertwined with a team process feedback loop predict how team members' individual motivations converge and then transform into team‐level motivation through a process of identity construction. Propositions for testing the model are advanced, as well as suggestions for methodological and analytical considerations.
Efficacy and safety of established and off‐label ADHD drug therapies for cognitive impairment or attention‐deficit hyperactivity disorder symptoms in bipolar disorder: A systematic review by the ISBD Targeting Cognition Task Force
Authors: Miskowiak Kamilla W. , Obel Zacharias K. , Guglielmo Riccardo , Bonnin Caterina del Mar , Bowie Christopher R. , Balanzá‐Martínez Vicent , Burdick Katherine E. , Carvalho Andre F. , Dols Annemieke , Douglas Katie , Gallagher Peter , Kessing Lars V. , Lafer Beny , Lewandowski Kathryn E. , López‐Jaramillo Carlos , Martinez‐Aran Anabel , McIntyre Roger S. , Porter Richard J. , Purdon Scot E. , Schaffer Ayal , Stokes Paul R. A. , Sumiyoshi Tomiki , Torres Ivan J. , Van Rheenen Tamsyn E. , Yatham Lakshmi N. , Young Allan H. , Vieta Eduard , Hasler Gregor 
Published: March 2024

AbstractBackgroundAbnormalities in dopamine and norepinephrine signaling are implicated in cognitive impairments in bipolar disorder (BD) and attention‐deficit hyperactivity disorder (ADHD). This systematic review by the ISBD Targeting Cognition Task Force therefore aimed to investigate the possible benefits on cognition and/or ADHD symptoms and safety of established and off‐label ADHD therapies in BD.MethodsWe included studies of ADHD medications in BD patients, which involved cognitive and/or safety measures. We followed the procedures of the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) 2020 statement. Searches were conducted on PubMed, Embase and PsycINFO from inception until June 2023. Two authors reviewed the studies independently using the Revised Cochrane Collaboration's Risk of Bias tool for Randomized trials.ResultsSeventeen studies were identified (N = 2136), investigating armodafinil (k = 4, N = 1581), methylphenidate (k = 4, N = 84), bupropion (k = 4, n = 249), clonidine (k = 1, n = 70), lisdexamphetamine (k = 1, n = 25), mixed amphetamine salts (k = 1, n = 30), or modafinil (k = 2, n = 97). Three studies investigated cognition, four ADHD symptoms, and 10 the safety. Three studies found treatment‐related ADHD symptom reduction: two involved methylphenidate and one amphetamine salts. One study found a trend towards pro‐cognitive effects of modafinil on some cognitive domains. No increased risk of (hypo)mania was observed. Five studies had low risk of bias, eleven a moderate risk, and one a serious risk of bias.ConclusionsMethylphenidate or mixed amphetamine salts may improve ADHD symptoms in BD. However, there is limited evidence regarding the effectiveness on cognition. The medications produced no increased mania risk when used alongside mood stabilizers. Further robust studies are needed to assess cognition in BD patients receiving psychostimulant treatment alongside mood stabilizers.
DNA methylation variation after a parenting program for child conduct problems: Findings from a randomized controlled trial
Authors: Creasey Nicole , Leijten Patty , Tollenaar Marieke S. , Boks Marco P. , Overbeek Geertjan 
Published: March 2024

AbstractThis study investigated associations of the Incredible Years (IY) parenting program with children's DNA methylation. Participants were 289 Dutch children aged 3–9 years (75% European ancestry, 48% female) with above‐average conduct problems. Saliva was collected 2.5 years after families were randomized to IY or care as usual (CAU). Using an intention‐to‐treat approach, confirmatory multiple‐regression analyses revealed no significant differences between the IY and CAU groups in children's methylation levels at the NR3C1 and FKBP5 genes. However, exploratory epigenome‐wide analyses revealed nine differentially methylated regions between groups, coinciding with SLAMF1, MITF, FAM200B, PSD3, SNX31, and CELSR1. The study provides preliminary evidence for associations of IY with children's salivary methylation levels and highlights the need for further research into biological outcomes of parenting programs.
Examining Child Labour in Stone Quarrying in the GA West Municipality, Ghana
Authors: Sedegah Daniella Delali 
Published: March 2024

ABSTRACTChild labour is a complex social problem worldwide, affecting the physical, moral and educational development of children. A cross sectional quantitative survey research design was used to assess child labour in quarrying activities of the Ga West Municipality, Ghana. The municipality was selected due to evidence in literature of children engaging in quarrying activities. The study examined child labour occurrence and intensity, the working condition of child labourers in the stone quarries; factors influencing child labour in quarrying activities; and the impact of quarrying activities on children. Data which were analysed using probit model and descriptive statistics indicated a negative effect of stone quarry activity on the development, growth and education of the child. Significant influencers were poverty, attitude and poor perception of parents, broken homes, traditional belief systems and migration. The study recommends offering educational support, grants and essential resources to vulnerable households in order to ensure that children remain in school.
Tetrahedral framework nucleic acids‐based delivery of MicroRNA‐22 inhibits pathological neovascularization and vaso‐obliteration by regulating the Wnt pathway
Authors: Liu Xinyu , Xu Xiaoxiao , Lai Yanting , Zhou Xiaodi , Chen Limei , Wang Qiong , Jin Yili , Luo Delun , Ding Xiaoyan 
Published: March 2024

AbstractThe objective of this study was to investigate the effects and molecular mechanisms of tetrahedral framework nucleic acids‐microRNA22 (tFNAs‐miR22) on inhibiting pathological retinal neovascularization (RNV) and restoring physiological retinal vessels. A novel DNA nanocomplex (tFNAs‐miR22) was synthesised by modifying microRNA‐22 (miR22) through attachment onto tetrahedral frame nucleic acids (tFNAs), which possess diverse biological functions. Cell proliferation, wound healing, and tube formation were employed for in vitro assays to investigate the angiogenic function of cells. Oxygen‐induced retinopathy (OIR) model was utilised to examine the effects of reducing pathological neovascularization (RNV) and inhibiting vascular occlusion in vivo. In vitro, tFNAs‐miR22 demonstrated the ability to penetrate endothelial cells and effectively suppress cell proliferation, tube formation, and migration in a hypoxic environment. In vivo, tFNAs‐miR22 exhibited promising results in reducing RNV and promoting the restoration of normal retinal blood vessels in OIR model through modulation of the Wnt pathway. This study provided a theoretical basis for the further understanding of RNV, and highlighted the innovative and potential of tFNAs‐miR22 as a therapeutic option for ischemic retinal diseases.
Pulmonary scedosporiosis in an intractable immunocompetent host: A case report and literature review
Authors: Liang Hong Yu , Han Chun Hua , Xu Wen Juan , Sun Jian , Wang Qiang 
Published: March 2024

AbstractPulmonary scedosporiosis is a rare pulmonary infection that often presents with nonspecific symptoms and radiological findings. In this report, we present a case of localized pulmonary scedosporiosis in an immunocompetent patient and analyze a total of 25 immunocompetent patients with pulmonary scedosporiosis. Through this case and the literature, we highlight the importance of considering pulmonary scedosporiosis in patients with nonspecific clinical symptoms and radiological findings resembling aspergilloma. This case and the literature further emphasize the significance of surgical intervention. Regardless of the use of antifungal drugs, surgery should be conducted as soon as possible.
Adulteration and substitution of drugs purchased in Australia from cryptomarkets: An analysis of Test4Pay
Authors: Barratt Monica J. , Ball Matthew , Wong Gabriel T. W. , Quinton Angus 
Published: March 2024

AbstractIntroductionProhibited drugs in unregulated markets may be adulterated, resulting in increased risks for people who use drugs. This study investigated levels of drug adulteration and substitution of drugs purchased in Australia from cryptomarkets.MethodsData were collected from a darknet forum called Test4Pay from 1 September 2022 to 23 August 2023. Posts were included if they reported the results of drug samples submitted by post to the Vancouver‐based Get Your Drugs Tested service, which uses Fourier‐transform infrared spectroscopy with immunoassay strip tests (fentanyl and benzodiazepines).ResultsOf 103 samples, 65% contained only the advertised substance, 14% contained the advertised substance in combination with other psychoactive and/or potentially harmful substances and for 21%, the advertised substance was absent. Substances sold as MDMA, methamphetamine or heroin were consistently found to contain only the advertised substance, while substances sold as 2C‐B, alprazolam or ketamine were the most likely to be completely substituted. Only 4 samples sold as cocaine contained solely the advertised substance, with 13 containing cocaine with adulterants like lidocaine, creatine, levamisole and boric acid (n = 19). No fentanyl contamination was detected. Novel dissociatives and novel benzodiazepines were detected, as well as a nitazene compound.Discussion and ConclusionsDrug markets under prohibition continue to contain numerous unexpected substances, some of which can elevate risk of harm. Cryptomarkets are not immune to this problem, despite review systems, which should, in theory, make vendors more accountable for the quality of their stock. These findings demonstrate a need for expansion of local drug checking services in Australia.
Testosterone therapy reduces insulin resistance in men with adult‐onset testosterone deficiency and metabolic syndrome. Results from the Moscow Study, a randomized controlled trial with an open‐label phase
Authors: Tishova Yuliya , Kalinchenko Svetlana , Mskhalaya George , Hackett Geoffrey , Livingston Mark , König Carola , Strange Richard , Zitzmann Michael , Mann Amar , Maarouf Amro , Ramachandran Sudarshan 
Published: March 2024

AbstractAimsTo describe changes in homeostasis model assessment of insulin resistance index (HOMA‐IR) following testosterone therapy in men with hypogonadism and metabolic syndrome (MetS).Materials and MethodsA randomized, placebo‐controlled, double‐blind randomized controlled trial (RCT) comprising 184 men with MetS and hypogonadism (testosterone undecanoate [TU]: 113 men, placebo: 71 men) was conducted. This was followed by an open‐label phase in which all men were given TU. We focused on men who were not receiving antiglycaemic agents (TU: 81 men; placebo: 54 men) as these could affect HOMA‐IR. Inter‐group comparison of HOMA‐IR was restricted to the RCT (30 weeks), whilst intra‐group comparison was carried out on men provided TU during the RCT and open‐label phases (study cohort) and men given placebo during the RCT and then switched to TU during the open‐label phase (confirmatory cohort). Regression analysis was performed to identify factors associated with change in HOMA‐IR (∆HOMA‐IR).ResultsThe median HOMA‐IR was significantly reduced at almost every time point (after 18 weeks) compared to baseline in men receiving TU in both the study and confirmatory cohorts. There was a significant decrease in median values of fasting glucose (30 weeks: −2.1%; 138 weeks: −4.9%) and insulin (30 weeks: −10.5%; 138 weeks: −35.5%) after TU treatment. Placebo was not associated with significant ∆HOMA‐IR. The only consistent predictor of HOMA‐IR decrease following TU treatment was baseline HOMA‐IR (r2 ≥ 0.64).ConclusionsBaseline HOMA‐IR predicted ΔHOMA‐IR, with a greater percentage change in insulin than in fasting glucose. In men with MetS/type 2 diabetes (T2DM) not on antiglycaemic therapy, improvements in HOMA‐IR may be greater than suggested by change in fasting glucose. Our results suggest that hypogonadism screening be included in the management of men with MetS/T2DM.
Accelerated onset of diabetes in non‐obese diabetic mice fed a refined high‐fat diet
Authors: Batdorf Heidi M. , Lawes Luz de Luna , Cassagne Gabrielle A. , Fontenot Molly S. , Harvey Innocence C. , Richardson Jeremy T. , Burk David H. , Dupuy Samuel D. , Karlstad Michael D. , Salbaum J. Michael , Staszkiewicz Jaroslaw , Beyl Robbie , Ghosh Sujoy , Burke Susan J. , Collier J. Jason 
Published: March 2024

AbstractAimType 1 diabetes results from autoimmune events influenced by environmental variables, including changes in diet. This study investigated how feeding refined versus unrefined (aka ‘chow’) diets affects the onset and progression of hyperglycaemia in non‐obese diabetic (NOD) mice.MethodsFemale NOD mice were fed either unrefined diets or matched refined low‐ and high‐fat diets. The onset of hyperglycaemia, glucose tolerance, food intake, energy expenditure, circulating insulin, liver gene expression and microbiome changes were measured for each dietary group.ResultsNOD mice consuming unrefined (chow) diets developed hyperglycaemia at similar frequencies. By contrast, mice consuming the defined high‐fat diet had an accelerated onset of hyperglycaemia compared to the matched low‐fat diet. There was no change in food intake, energy expenditure, or physical activity within each respective dietary group. Microbiome changes were driven by diet type, with chow diets clustering similarly, while refined low‐ and high‐fat bacterial diversity also grouped closely. In the defined dietary cohort, liver gene expression changes in high‐fat‐fed mice were consistent with a greater frequency of hyperglycaemia and impaired glucose tolerance.ConclusionGlucose intolerance is associated with an enhanced frequency of hyperglycaemia in female NOD mice fed a defined high‐fat diet. Using an appropriate matched control diet is an essential experimental variable when studying changes in microbiome composition and diet as a modifier of disease risk.
Evidence for interictal blood–brain barrier dysfunction in people with epilepsy
Authors: Reiter Johannes T. , Schulte Freya , Bauer Tobias , David Bastian , Endler Christoph , Isaak Alexander , Schuch Fabiane , Bitzer Felix , Witt Juri‐Alexander , Hattingen Elke , Deichmann Ralf , Attenberger Ulrike , Becker Albert J. , Helmstaedter Christoph , Radbruch Alexander , Surges Rainer , Friedman Alon , Rüber Theodor 
Published: March 2024

AbstractObjectiveInterictal blood–brain barrier dysfunction in chronic epilepsy has been demonstrated in animal models and pathological specimens. Ictal blood–brain barrier dysfunction has been shown in humans in vivo using an experimental quantitative magnetic resonance imaging (MRI) protocol. Here, we hypothesized that interictal blood–brain barrier dysfunction is also present in people with drug‐resistant epilepsy.MethodsThirty‐nine people (21 females, mean age at MRI ± SD = 30 ± 8 years) with drug‐resistant epilepsy were prospectively recruited and underwent interictal T1‐relaxometry before and after administration of a paramagnetic contrast agent. Likewise, quantitative T1 was acquired in 29 people without epilepsy (12 females, age at MRI = 48 ± 18 years). Quantitative T1 difference maps were calculated and served as a surrogate imaging marker for blood–brain barrier dysfunction. Values of quantitative T1 difference maps inside hemispheres ipsilateral to the presumed seizure onset zone were then compared, on a voxelwise level and within presumed seizure onset zones, to the contralateral side of people with epilepsy and to people without epilepsy.ResultsCompared to the contralateral side, ipsilateral T1 difference values were significantly higher in white matter (corrected p < .05), gray matter (uncorrected p < .05), and presumed seizure onset zones (p = .04) in people with epilepsy. Compared to people without epilepsy, significantly higher T1 difference values were found in the anatomical vicinity of presumed seizure onset zones (p = .004). A subgroup of people with hippocampal sclerosis demonstrated significantly higher T1 difference values in the ipsilateral hippocampus and in regions strongly interconnected with the hippocampus compared to people without epilepsy (corrected p < .01). Finally, z‐scores reflecting the deviation of T1 difference values within the presumed seizure onset zone were associated with verbal memory performance (p = .02) in people with temporal lobe epilepsy.SignificanceOur results indicate a blood–brain barrier dysfunction in drug‐resistant epilepsy that is detectable interictally in vivo, anatomically related to the presumed seizure onset zone, and associated with cognitive deficits.
Revolutionizing family courts: Catalysts for reform and the transformative role of technology
Authors: Altobelli Tom , McKenna Erin , Suh Isabel 
Published: March 2024

AbstractThis article examines the multiple inter‐connected and interacting catalysts for past, current and future family court reform. We then, with deep humility and quiet ambition, contemplate the next 50 years and hypothesize about future court reform which we predict will focus on technology. We observe how what was once a fanciful idea for family courts (such as electronic filing and online court events) is realistic today. We contend that, in a similar vein, the technological reforms postulated in this article (such as judgment writing assisted by artificial intelligence) may become the reality of the future.
Becoming a mother in neoliberal academia: Subjectivation and self‐identity among early career researchers
Authors: Russo Concetta 
Published: March 2024

AbstractThis paper investigates how becoming a mother—and navigating such a complicated life transition—while pursuing an academic career impacts the way female researchers perceive themselves as acting subjects. By analyzing in‐depth virtual interviews with Italian female early career researchers, this work explores the relationship between fertility decisions, motherhood hardships, self‐identity, and career‐related experiences in the interviewees' biographical trajectories. Despite their consideration of childbearing as a mental and practical obstacle to scientific production, many of the interviewees ascribe positive career outcomes to the arrival of their first child. The reflexivity set in motion by the interview process allows us to observe the collected interviews as double‐layered narratives. The postponement of fertility choices and the presence of work‐family conflict tend to be described as ordinary facets of a common career pattern, intrinsic to the female academic working experience. Meanwhile, the positive impacts of motherhood on self‐identity and work‐related skills are recounted on a more individual level, framed as a sort of paradox, a personal journey of self‐discovery or—to some extent ‐ a heroic performance.
Patient and public involvement in the development of health services: Engagement of underserved populations in a quality improvement programme for inflammatory bowel disease using a community‐based participatory approach
Authors: Sheldon Elena , Ezaydi Naseeb , Ditmore Melanie , Fuseini Olga , Ainley Rachel , Robinson Kerry , Hind Daniel , Lobo Alan J. 
Published: March 2024

AbstractIntroductionInvolving people with lived experience is fundamental to healthcare development and delivery. This is especially true for inflammatory bowel disease (IBD) services, where holistic and personalised models of care are becoming increasingly important. There is, however, a significant lack of representation of underserved and diverse groups in IBD research, and there are significant barriers to healthcare access and utilisation among minority groups in IBD. IBD centres need to be aware of these experiences to address barriers via service changes, improve interactions with local communities and promote meaningful engagement for improved health outcomes.MethodsA pragmatic community‐based approach was taken to engage with leaders and members of underserved groups across 11 workshops representing Roma, Afro‐Caribbean, people of African descent and the wider black, Asian and minority ethnic (BAME) communities, Muslim women, refugee community members, deprived areas of South Yorkshire, LGBTQ+ and deaf populations. Thematic analysis of field notes identified patterns of attention across the community groups and where improvements to services were most frequently suggested.ResultsFindings demonstrated several barriers experienced to healthcare access and utilisation, including language accessibility, staff attitudes and awareness, mental health and stigma, continuity of support, and practical factors such as ease of service use and safe spaces. These barriers acted as a lever to co‐producing service changes that are responsive to the health and social care needs of these groups.ConclusionsEngaging with people from a range of communities is imperative for ensuring that service improvements in IBD are accessible and representative of individual needs and values.Patient or Public ContributionLocal community leaders and members of community groups actively participated in the co‐design and development of improvements to the IBD service for a local hospital. Their contributions further informed a pilot process for quality improvement programmes in IBD centres.