bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complexity of Translating Analytics to Recent Cannabis Use and Impairment
Authors: DeGregorio Michael W , Kao Chiao-Jung , Wurz Gregory T 
Published: February 2024

Abstract
While current analytical methodologies can readily identify cannabis use, definitively establishing recent use within the impairment window has proven to be far more complex, requiring a new approach. Recent studies have shown no direct relationship between impairment and Δ9-tetra-hydrocannabinol (Δ9-THC) concentrations in blood or saliva, making legal “per se” Δ9-THC limits scientifically unjustified. Current methods that focus on Δ9-THC and/or metabolite concentrations in blood, saliva, urine, or exhaled breath can lead to false-positive results for recent use due to the persistence of Δ9-THC well outside of the typical 3–4 h window of potential impairment following cannabis inhalation. There is also the issue of impairment due to other intoxicating substances—just because a subject exhibits signs of impairment and cannabis use is detected does not rule out the involvement of other drugs. Compounding the matter is the increasing popularity of hemp-derived cannabidiol (CBD) products following passage of the 2018 Farm Bill, which legalized industrial hemp in the United States. Many of these products contain varying levels of Δ9-THC, which can lead to false-positive tests for cannabis use. Furthermore, hemp-derived CBD is used to synthesize Δ8-THC, which possesses psychoactive properties similar to Δ9-THC and is surrounded by legal controversy. For accuracy, analytical methods must be able to distinguish the various THC isomers, which have identical masses and exhibit immunological cross-reactivity. A new testing approach has been developed based on exhaled breath and blood sampling that incorporates kinetic changes and the presence of key cannabinoids to detect recent cannabis use within the impairment window without the false-positive results seen with other methods. The complexity of determining recent cannabis use that may lead to impairment demands such a comprehensive method so that irresponsible users can be accurately detected without falsely accusing responsible users who may unjustly suffer harsh, life-changing consequences.
One-carbon metabolite supplementation to nutrient-restricted beef heifers affects placental vascularity during early pregnancy
Authors: Kanjanaruch Chutikun , Bochantin Kerri A , Dávila Ruiz Bethania J , Syring Jessica , Entzie Yssi , King Layla , Borowicz Pawel P , Crouse Matthew S , Caton Joel S , Dahlen Carl R , Ward Alison K , Reynolds Lawrence P 
Published: February 2024

Abstract
We hypothesized that restricted maternal nutrition and supplementation of one-carbon metabolites (OCM; methionine, folate, choline, and vitamin B12) would affect placental vascular development during early pregnancy. A total of 43 cows were bred, and 32 heifers successfully became pregnant with female calves, leading to the formation of four treatment groups: CON − OCM (n = 8), CON + OCM (n = 7), RES − OCM (n = 9), and RES + OCM (n = 8). The experimental design was a 2 × 2 factorial, with main factors of dietary intake affecting average daily gain: control (CON; 0.6 kg/d ADG) and restricted (RES; −0.23 kg/d ADG); and OCM supplementation (+OCM) in which the heifers were supplemented with rumen-protected methionine (7.4 g/d) and choline (44.4 g/d) and received weekly injections of 320 mg of folate and 20 mg of vitamin B12, or received no supplementation (−OCM; corn carrier and saline injections). Heifers were individually fed and randomly assigned to treatment at breeding (day 0). Placentomes were collected on day 63 of gestation (0.225 of gestation). Fluorescent staining with CD31 and CD34 combined with image analysis was used to determine the vascularity of the placenta. Images were analyzed for capillary area density (CAD) and capillary number density (CND). Areas evaluated included fetal placental cotyledon (COT), maternal placental caruncle (CAR), whole placentome (CAR + COT), intercotyledonary fetal membranes (ICOT, or chorioallantois), intercaruncular endometrium (ICAR), and endometrial glands (EG). Data were analyzed with the GLM procedure of SAS, with heifer as the experimental unit and significance at P ≤ 0.05 and a tendency at P &gt; 0.05 and P &lt; 0.10. Though no gain × OCM interactions existed (P ≥ 0.10), OCM supplementation increased (P = 0.01) CAD of EG, whereas nutrient restriction tended (P &lt; 0.10) to increase CAD of ICOT and CND of COT. Additionally, there was a gain × OCM interaction (P &lt; 0.05) for CAD within the placentome and ICAR, such that RES reduced and supplementation of RES with OCM restored CAD. These results indicate that maternal rate of gain and OCM supplementation affected placental vascularization (capillary area and number density), which could affect placental function and thus the efficiency of nutrient transfer to the fetus during early gestation.
Optimizing the Patient Experience for Women With Disabilities in the Breast Imaging Clinic
Authors: Net Jose M , Feliciano Yara Z , Podsiadlo Victoria , Dialani Vandana , Grimm Lars J 
Published: February 2024

Abstract
While there are varying opinions on what age to begin and at what interval to perform breast cancer screening, screening mammography is recommended for all women irrespective of disability. Unfortunately, women with disabilities are more likely to present with later-stage disease and higher mortality owing to the barriers for more widespread screening in this population. Women with disabilities may experience challenges accessing breast imaging services, and imaging centers may have suboptimal facilities and staff who are inexperienced in caring for this population. Efforts to increase accessibility by employing universal design to increase ease of access and provide training to improve the patient experience will go far to improve outcomes for patients with disabilities. To date, there exists no comprehensive guidance on how to improve breast cancer screening programs for women with disabilities. The purpose of this paper is to review barriers to screening faced by patients with disabilities, describe strategies to overcome these barriers, and provide guidance for radiologists and referring providers in selecting the best exam for the individual patient.
Policies or Prejudices? An Analysis of Antisemitic and Anti-Israel Views on Social Media and Social Surveys
Authors: Binstok Noam , Gould Eric D , Kaplan Todd 
Published: February 2024

Abstract
This paper examines the extent to which personal biases affect political views, in the context of how antisemitism influences opinions about Israel. Two empirical analyses are conducted. The first one analyzes social media chatter about Jews and Israel in the UK, revealing a strong, positive relationship between negative chatter about both of them at the daily-location level. In order to establish causality, social media chatter about a “Jewish” football team in the English Premier League (Tottenham) is used as an instrument for negative expressions about Jewish people to explain negativity toward Israel. The second empirical analysis uses the 2016 wave of the German Social Survey, which reveals a strong and robust relationship between several commonly used measures of antisemitic beliefs and holding anti-Israel views. A causal interpretation of this finding is supported by an IV analysis motivated by Voigtländer and Voth who show that Nazi indoctrination during the WWII period had a lifelong impact on antisemitic views. In both analyses, the IV estimates are considerably larger than OLS coefficients.
A convolutional neural network for creating near-surface 2D velocity images from GPR antenna measurements
Authors: Iqbal Ibrar , Xiong Bin , Peng Shanxi , Wang Honghua 
Published: February 2024

Abstract
In this research, our focus lies in exploring the effectiveness of a frequency-velocity convolutional neural network (CNN) in the efficient and non-intrusive acquisition of 2D wave velocity visuals of near-surface geological substances, accomplished through the analysis of data from ground-penetrating radar (GPR). To learn complex correlations between antenna readings and subsurface velocities, the proposed CNN model makes use of the spatial features present in the GPR data. By employing a network architecture capable of accurately detecting both local and global patterns within the data, it becomes feasible to efficiently extract valuable velocity information from GPR readings. The CNN model is trained and validated using a substantial dataset consisting of GPR readings along with corresponding ground truth velocity images. Diverse subsurface settings, encompassing different soil types and geological characteristics, are employed to gather the GPR measurements. In the supervised learning approach employed to train the CNN model, the GPR measurements serve as input, while the associated ground truth velocity images are utilized as target outputs. The model is trained using backpropagation and optimized using a suitable loss function to reduce the difference between the predicted velocity images and the actual images. The experimental results demonstrate the effectiveness of the proposed CNN method in accurately deriving 2D velocity images of near-surface materials from GPR antenna observations. Compared to traditional techniques, the CNN model exhibits superior velocity calculation precision and achieves high levels of accuracy. Moreover, when applied to unseen GPR data, the trained model exhibits promising generalization abilities, highlighting its potential for practical subsurface imaging applications.
Association between diet quality and ovarian cancer risk and survival
Authors: Cao Anlan , Esserman Denise A , Cartmel Brenda , Irwin Melinda L , Ferrucci Leah M 
Published: February 2024

Abstract

Background
Research on diet quality and ovarian cancer is limited. We examined the association between diet quality and ovarian cancer risk and survival in a large prospective cohort.

Methods
We used data from women in the prospective National Institutes of Health–AARP Diet and Health Study enrolled from 1995 to 1996 who were aged 50-71 years at baseline with follow-up through December 31, 2017. Participants completed a 124-item food frequency questionnaire at baseline, and diet quality was assessed via the Healthy Eating Index-2015, the alternate Mediterranean diet score, and the Dietary Approaches to Stop Hypertension score. Primary outcomes were first primary epithelial ovarian cancer diagnosis from cancer registry data and among those diagnosed with ovarian cancer all-cause mortality. We used a semi-Markov multistate model with Cox proportional hazards regression to account for semicompeting events.

Results
Among 150 643 participants with a median follow-up time of 20.5 years, 1107 individuals were diagnosed with a first primary epithelial ovarian cancer. There was no evidence of an association between diet quality and ovarian cancer risk. Among those diagnosed with epithelial ovarian cancer, 893 deaths occurred with a median survival of 2.5 years. Better prediagnosis diet quality, according to the Healthy Eating Index-2015 (quintile 5 vs quintile 1: hazard ratio [HR] = 0.75, 95% confidence interval [CI] = 0.60 to 0.93) and alternate Mediterranean diet score (quintile 5 vs quintile 1: HR = 0.68, 95% CI = 0.53 to 0.87), was associated with lower all-cause mortality. There was no evidence of an association between Dietary Approaches to Stop Hypertension score and all-cause mortality.

Conclusions
Better prediagnosis diet quality was associated with lower all-cause mortality after ovarian cancer diagnosis but was not associated with ovarian cancer risk.
The Effects of Placement and Order on Consent to Data Linkage in a Web survey
Authors: Burton Jonathan , Couper Mick P , Jäckle Annette 
Published: February 2024

Abstract
We report on an experiment in a supplemental web survey as part of a longitudinal study in the United Kingdom where we ask survey respondents to consent to two forms of data linkage to health records and to consent to be mailed a serology kit. We varied the placement (early, early in context, or late in the survey) and order (linkage first or serology first) of the consent requests. We also examine reasons for consent or non-consent. We find that order of the requests does not make much difference, but making the requests early in the survey significantly increases consent rates over asking them after a series of content-related questions (by 3.4 percentage points) or later in the survey (by 7.2 percentage points). This is consistent with previous research showing that early requests for consent in a survey have a positive effect. The main reason chosen for not consenting related to the personal nature of the information requested.
The transcription factor ThDOF8 binds to a novel cis-element and mediates molecular responses to salt stress in Tamarix hispida
Authors: Wang Peilong , Wang Danni , Li Yongxi , Li Jinghang , Liu Baichao , Wang Yuanyuan , Gao Caiqiu 
Published: February 2024

Abstract
Salt stress is a common abiotic factor that restricts plant growth and development. As a halophyte, Tamarix hispida is a good model plant for exploring salt-tolerance genes and regulatory mechanisms. DNA-binding with one finger (DOF) is an important transcription factor (TF) that influences and controls various signaling substances involved in diverse biological processes related to plant growth and development, but the regulatory mechanisms of DOF TFs in response to salt stress are largely unknown in T. hispida. In the present study, a newly identified Dof gene, ThDOF8, was cloned from T. hispida, and its expression was found to be induced by salt stress. Transient overexpression of ThDOF8 enhanced T. hispida salt tolerance by enhancing proline levels, and increasing the activities of the antioxidant enzymes superoxide dismutase (SOD) and peroxidase (POD). These results were also verified in stably transformed Arabidopsis. Results from TF-centered yeast one-hybrid (Y1H) assays and EMSAs showed that ThDOF8 binds to a newly identified cis-element (TGCG). Expression profiling by gene chip analysis identified four potential direct targets of ThDOF8, namely the cysteine-rich receptor-like kinases genes, CRK10 and CRK26, and two glutamate decarboxylase genes, GAD41, and GAD42, and these were further verified by ChIP–quantitative-PCR, EMSAs, Y1H assays, and β-glucuronidase enzyme activity assays. ThDOF8 can bind to the TGCG element in the promoter regions of its target genes, and transient overexpression of ThCRK10 also enhanced T. hispida salt tolerance. On the basis of our results, we propose a new regulatory mechanism model, in which ThDOF8 binds to the TGCG cis-element in the promoter of the target gene CRK10 to regulate its expression and improve salt tolerance in T. hispida. This study provides a basis for furthering our understanding the role of DOF TFs and identifying other downstream candidate genes that have the potential for improving plant salt tolerance via molecular breeding.
Isolation of Lactobacillus acidophilus strain and its anti-obesity effect in a diet induced obese murine model
Authors: Zheng Yanyi , Zhang Silu , Zhang Zhizhu , Zhang Tengxun , Teng Xin , Xiao Guoxun , Huang Song 
Published: February 2024

Abstract
Intestinal microbiota is a potential determinant of obesity, with probiotic bile salt hydrolase (BSH) as one of the key mechanisms in the anti-obesity effects. In this study, we present a Lactobacillus acidophilus GOLDGUT-LA100 (LA100) with high BSH activity, good gastric acid and bile salt tolerance, and a potential anti-obesity effect. LA100’s anti-obesity effects were evaluated in a high-fat diet-induced, obese mouse model. LA100 administration alleviates high-fat diet-induced pathophysiological symptoms, such as body weight gain, high serum glucose and cholesterol level, hepatic lipid accumulation, and adipose inflammation. These results demonstrate concrete anti-obesity benefit in animal models and show promising applications in future clinical studies.
Persistent MRI Findings Unique to Blast and Repetitive Mild TBI: Analysis of the CENC/LIMBIC Cohort Injury Characteristics
Authors: Tate David F , Wade Benjamin S C , Velez Carmen S , Bigler Erin D , Davenport Nicholas D , Dennis Emily L , Esopenko Carrie , Hinds Sidney R , Kean Jacob , Kennedy Eamonn , Kenney Kimbra , Mayer Andrew R , Newsome Mary R , Philippi Carissa L , Pugh Mary J , Scheibel Randall S , Taylor Brian A , Troyanskaya Maya , Werner John K , York Gerald E , Walker William , Wilde Elisabeth A 
Published: February 2024

ABSTRACT

Introduction
MRI represents one of the clinical tools at the forefront of research efforts aimed at identifying diagnostic and prognostic biomarkers following traumatic brain injury (TBI). Both volumetric and diffusion MRI findings in mild TBI (mTBI) are mixed, making the findings difficult to interpret. As such, additional research is needed to continue to elucidate the relationship between the clinical features of mTBI and quantitative MRI measurements.

Material and Methods
Volumetric and diffusion imaging data in a sample of 976 veterans and service members from the Chronic Effects of Neurotrauma Consortium and now the Long-Term Impact of Military-Relevant Brain Injury Consortium observational study of the late effects of mTBI in combat with and without a history of mTBI were examined. A series of regression models with link functions appropriate for the model outcome were used to evaluate the relationships among imaging measures and clinical features of mTBI. Each model included acquisition site, participant sex, and age as covariates. Separate regression models were fit for each region of interest where said region was a predictor.

Results
After controlling for multiple comparisons, no significant main effect was noted for comparisons between veterans and service members with and without a history of mTBI. However, blast-related mTBI were associated with volumetric reductions of several subregions of the corpus callosum compared to non–blast-related mTBI. Several volumetric (i.e., hippocampal subfields, etc.) and diffusion (i.e., corona radiata, superior longitudinal fasciculus, etc.) MRI findings were noted to be associated with an increased number of repetitive mTBIs versus.

Conclusions
In deployment-related mTBI, significant findings in this cohort were only observed when considering mTBI sub-groups (blast mechanism and total number/dose). Simply comparing healthy controls and those with a positive mTBI history is likely an oversimplification that may lead to non-significant findings, even in consortium analyses.
Orbital evolution of eccentric perturbers under dynamical friction: crossing the sound barrier
Authors: Buehler Robin , Kolyada Roman , Desjacques Vincent 
Published: February 2024

ABSTRACT
In a gaseous medium, dynamical friction (DF) reaches a maximum when the orbital speed of a (point-like) perturber moving on a circular orbit is close to the sound speed. Therefore, in a quasi-steady state, eccentric orbits of perturbers approaching the sound barrier (from below) should rapidly circularize as they experience the strongest drag at pericentre passage. To investigate this effect, we extend the solution for circular DF in a uniform gaseous medium to eccentric Keplerian orbits. We derive an approximation to the steady-state DF force, which is valid for eccentricities as high as e = 0.9 in a limited range of Mach number around the transition to supersonic regime. We validate our analytical result with 3D simulations of the gas density response. Although gaseous DF generally dissipates orbital energy, we find that it can be directed along the motion of the perturber near pericentre passage when the eccentricity is e ≳ 0.9. We apply our results to compute the long-time evolution of the orbital parameters. Most trajectories tend to circularize as the perturber moves into the supersonic regime. However, orbits with eccentricities e ≳ 0.8 below the sound barrier experience a slight increase in eccentricity as they loose orbital energy. Possible extensions to our analytical approach are also discussed.
Distant activity of long-period comets C/2019 L3 (ATLAS) and C/2020 P3 (ATLAS)
Authors: Sun Shaofeng , Shi Jianchun , Ma Yuehua , Zhao Haibin 
Published: February 2024

ABSTRACT
Long-period comets C/2019 L3 (ATLAS) and C/2020 P3 (ATLAS) remain active at heliocentric distance greater than 4 au. Broad-band Charge-Coupled Device (CCD) photometry of long-period comets C/2019 L3 and C/2020 P3 is analysed in this paper. The observation was obtained with three telescopes: ZEISS-1000 at Simeiz Observatory, Maksutov at Abastumani Astrophysical Observatory, and ZTSh at Crimean Astrophysical Observatory. The R-band A(0)fρ values of C/2019 L3 range from (5043 ± 244) to (13611 ± 1874) cm, and tend to decrease first and then increase. The average colour indices of C/2019 L3 are B–V = 0.75 ± 0.06, V–R = 0.28 ± 0.05, and R–I = 0.21 ± 0.05. The reddening of C/2019 L3 exhibits variations during the observational runs, ranging from (13.75 ± 1.07) to (−15.69 ± 0.37) per cent/kÅ with an average value of (0.94 ± 0.23) per cent/kÅ. It possesses a non-steady coma since the average gradient of its surface brightness profile is −1.60. For comet C/2020 P3, its R-band A(0)fρ values range from (606 ± 31) to (869 ± 20) cm, the colour indices are B–V = 1.04 ± 0.09, V–R = 0.26 ± 0.05, and R–I = 0.76 ± 0.04, and the reddening is (−6.65 ± 0.01) per cent/kÅ. The colour indices of the two comets differ from those of other long-period comets. Compared with other long-period comets, comet C/2019 L3 is very active at heliocentric distance of ∼4 au, while C/2020 P3 is moderately active at heliocentric distance of ∼7 au.
Dust accumulation near the magnetospheric truncation of protoplanetary discs – II. The effects of opacity and thermal evolution
Authors: Li Rixin , Chen Yi-Xian , Lin Douglas N C 
Published: February 2024

ABSTRACT
Dust trapping in the global pressure bump induced by magnetospheric truncation offers a promising formation mechanism for close-in super-Earths/sub-Neptunes. These planets likely form in evolved protoplanetary discs, where the gas temperature at the expanding truncation radius become amiable to refractory solids. However, dust accumulation may alter the disc opacity such that thermal evolution is inevitable. To better understand how thermodynamics affects this planet formation pathway, we conduct a suite of local dust evolution simulations in an idealized inner disc model. Our calculations take into account self-consistent opacity-dependent temperature changes as well as dust evaporation and vapour condensation. We find that disc thermal evolution regulates dust growth and evolution, discouraging any accumulation of small particles that drives the increase of opacity and temperature. Significant retention of dust mass takes place when the disc environments allow runaway growth of large solids beyond the fragmentation barrier, where small particles are then swept up and preserved. Our results further validate dust accumulation near disc truncation as a promising mechanism to form close-in planets.