bluuebunny/crossref_metadata_2025_split huggingface dataset:
EphB/EphrinB Receptors and Wnt Signaling in Colorectal Cancer
Authors: Clevers Hans , Batlle Eduard 
Published: January 2006

Abstract
Eph receptors and their ephrin ligands mediate cell repulsion during embryonic development. In the intestinal epithelium, EphB receptors are Wnt signaling target genes that control cell compartmentalization along the crypt axis. Recent findings have shown that this family of receptors are key players during colorectal cancer progression. Here, we review the current knowledge of the EphB/ephrinB system in the intestinal epithelium and we discuss their tumor suppressor role in the context of the multistep progression of colorectal cancer. (Cancer Res 2006; 66(1): 2-5)
Eco‐efficiency of Advanced Loop‐closing Systems for Vehicles and Household Appliances in Hyogo Eco‐town
Authors: Morioka Tohru , Tsunemi Kiyotaka , Yamamoto Yugo , Yabar Helmut , Yoshida Noboru 
Published: January 2006

SummaryThe closing of material loops is a critical challenge in industrial ecology. It relies mainly on the utilization of recovered materials/parts/products in the original and principal production system while their original function is retained at the highest level possible. In this study, advanced loop‐closing systems for the recycling of end‐of‐life vehicles and electric household appliances are first designed in “Hyogo Eco‐town.” Second, a methodology for evaluating the eco‐efficiency of these systems is developed. Finally, the eco‐efficiency of the designed advanced loop‐closing strategies for the two products is evaluated, based on the results of materials flow analysis and life‐cycle assessment.The results show that, compared with conventional recycling systems, when an industrial complex and an advanced loop‐closing system for end‐of‐life vehicles are established, the total economic value increases by 114% and the eco‐efficiency in terms of the amount of direct material input is improved by 57%. This system permits the utilization of the by‐products, wastes, and recovered materials that originate from other industrial sectors as input to production activities. In the case of end‐of‐life electric household appliances, an advanced loop‐closing strategy to lengthen the product life with parts reuse improves the eco‐efficiency in terms of carbon dioxide (CO2) emissions by 4% compared with the conventional replacement of the appliance with a new product along with the material recycling option.
Operational Eco‐efficiency: Comparing Firms' Environmental Investments in Different Domains of Operation
Authors: Scholz Roland W. , Wiek Arnim 
Published: January 2006

SummaryEco‐efficiency has been established as a crucial concept for corporate environmental management. Most approaches deal with eco‐efficiency on the level of the company or the product. However, given that companies have special budgets earmarked for environmental operations or investments, the question arises as to which operation within which domain is the most eco‐efficient. This article presents an approach to supporting these decisions by calculating eco‐efficiency on the operational level. The procedure is demonstrated using a case study of the Swiss National Railway Company. Investments and operations in the domains of energy production, landscape and nature conservation, noise protection, and contaminated soil remediation are assessed and compared. Decision‐makers seeking an eco‐efficient corporate investment policy will find, in this concept, a guideline for prioritizing various domains of operation as well as the operations within a domain.
Monetary Valuation of Emissions in Implementing Environmental Policy
Authors: Davidson Marc D. , Boon Bart H. , van Swigchem Jessica 
Published: January 2006

SummaryAt various levels of environmental policy making there is a demand to translate polluting emissions into monetary units. In the so‐called reduction cost approach, based upon policy targets, polluting emissions are expressed in monetary terms by determination of the marginal unit reduction cost at the emission target level. This approach provides shadow prices for emissions by which it can be established whether a certain measure or technology belongs to the most efficient set of measures by which the policy targets can be reached. This article argues that, if clear (generic) government targets such as national emission reduction targets exist for an emission, shadow prices derived by this method are to be preferred to shadow prices derived by other methods for decisions at the project (implementation) level. By application of the reduction cost approach, implementation decisions can be made that are both cost‐effective and consistent with government policy.
Childbirth in Early Imperial China
Authors: Lee Jen-Der 
Published: January 2006

AbstractBy the eighth century, medical texts had come to agree that an expecting mother should take herbal medicine in the last month of pregnancy to ensure a quick and safe delivery. Delivery charts, previously separated for different purposes, were integrated into one chart with twelve sub-charts for each month of the year. Women usually took vertical positions during delivery and were most likely supported under the arms by midwives. Ritual techniques and manual manipulations were applied to solve complications such as breech birth. The former often implied resonant relations between the baby, its mother and her husband, while the latter sometimes elicited criticism from male doctors as unnecessary interventions. The new mother would be restrained from social contact in the first month after delivery, because of both her need to rest and the fear of pollution. Friends and relatives, however, would bring over precious and nutritious food to "nourish her body," said the medical texts, "not just to celebrate the child."
Observations of the Structure of Heavily Precipitating Marine Stratocumulus
Authors: vanZanten M. C. , Stevens Bjorn 
Published: January 2006

Abstract
The second research flight of the Second Dynamics and Chemistry of Marine Stratocumulus (DYCOMS-II) field study is analyzed. This case attracted attention because it combined the presence of high drizzle rates with the occurrence of clearings in the cloud cover, which previous work has suggested could be due to a drizzle-induced change in cloud structure. Recent work has named the configuration of these open-cell-like features pocket of open cells (POC). A division of the data, based on the difference of brightness temperature of the 11- and 4-μm channels of the Geostationary Operational Environmental Satellite-10 (GOES-10), is used to condition averages over POC and non-POC sections of the data. Based on this division, significant precipitation is observed almost entirely within the POC. Overall, the observed PBL was markedly energetic and well mixed, commensurate with observations of similarly forced nonprecipitating boundary layers. Regions of elevated equivalent potential temperature, Θe, are encountered in association with the POC and are particularly pronounced below cloud in regions of active precipitation. In the same areas, evaporative cooling and moistening of the subcloud layer air and a marked reduction of the vertical velocity variance below cloud is noted. The POC, and in particular the drizzling areas in the POC, have a mean upward velocity, while the non-POC is associated with descending air. In addition to exhibiting more mesoscale variability the POC differs microphysically from the non-POC: in the POC liquid water amount is higher, cloud droplet number concentration lower, and the effective radii larger. Factors maintaining regions of elevated Θe are discussed, and targets for future modeling or observational studies are identified.
Fall Velocities of Hydrometeors in the Atmosphere: Refinements to a Continuous Analytical Power Law
Authors: Khvorostyanov Vitaly I. , Curry Judith A. 
Published: January 2006

Abstract
This paper extends the previous research of the authors on the unified representation of fall velocities for both liquid and crystalline particles as a power law over the entire size range of hydrometeors observed in the atmosphere. The power-law coefficients are determined as continuous analytical functions of the Best or Reynolds number or of the particle size. Here, analytical expressions are formulated for the turbulent corrections to the Reynolds number and to the power-law coefficients that describe the continuous transition from the laminar to the turbulent flow around a falling particle. A simple analytical expression is found for the correction of fall velocities for temperature and pressure. These expressions and the resulting fall velocities are compared with observations and other calculations for a range of ice crystal habits and sizes. This approach provides a continuous analytical power-law description of the terminal velocities of liquid and crystalline hydrometeors with sufficiently high accuracy and can be directly used in bin-resolving models or incorporated into parameterizations for cloud- and large-scale models and remote sensing techniques.
Updraft/Downdraft Constraints for Moist Baroclinic Modes and Their Implications for the Short-Wave Cutoff and Maximum Growth Rate
Authors: Zurita-Gotor Pablo 
Published: January 2006

AbstractThis paper examines the dynamics of moist baroclinic modes, based on the idealized model of moist baroclinic instability devised by Emanuel et al. These authors found that the finite static stability along the downdraft prevents the explosive short-wave cyclogenesis of the zero stratification limit in the moist problem, and allows only moderate (order 2) changes in the growth rate and short-wave cutoff, even when the moist static stability vanishes. To understand the limiting role of the dry static stability, a constraint is derived in this paper that relates the updraft and downdraft structures. This constraint is based on continuity and implies that a bulk wavenumber (defined in the paper) scales as the relevant deformation radius in each region.Because neutral solutions are separable, the vertical structure can be encapsulated in terms of a single, equivalent wavenumber based on the downdraft width. This allows an interpretation of the results in terms of the equivalent dry mode. As the ratio between moist and dry static stability decreases, the downdraft width takes an increasingly larger fraction of the total wavelength. In the limit of moist neutrality all the wavelength is occupied by the downdraft, so that the short-wave cutoff is halved.The vertical phase tilt makes unstable solutions nonseparable, and prevents defining an equivalent wavenumber in that case. However, the constraint between the bulk wavenumbers still applies. As the moist stability is reduced, the updraft solution becomes more suboptimal; in the limit of moist neutrality, the updraft wavenumber equals the short-wave cutoff. This provides a bound to the maximum growth rate in the moist problem, which is in agreement with the results of Emanuel et al.
Remote Sensing of Cirrus Cloud Particle Size and Optical Depth Using Polarimetric Sensor Measurements
Authors: Ou S. C. , Liou K. N. , Takano Y. , Slonaker R. L. 
Published: January 2006

AbstractThis paper presents a conceptual approach toward the remote sensing of cirrus cloud particle size and optical depth using the degree of polarization and polarized reflectance associated with the first three Stokes parameters, I, Q, and U, for the 0.865- and 2.25-μm wavelengths. A vector line-by-line equivalent radiative transfer program including the full Stokes parameters based on the adding method was developed. The retrieval algorithm employs the steepest-descent method in the form of a series of numerical iteration procedures to search for the simulated polarization parameters that best match the measured values. Sensitivity studies were performed to investigate the behavior of phase-matrix elements as functions of scattering angles for three ice crystal size–shape combinations. Overall, each phase-matrix element shows some sensitivity toward ice crystal shape, size, and surface roughness due to the various optical effects. Synthetic analysis reveals that the retrieval algorithm is highly accurate, while polarimetric and radiometric error sources cause very small retrieval errors. Finally, an illustrative example of applying the retrieval algorithm to airborne Polarization and Directionality of the Earth’s Reflectances (POLDER) data during the European Cloud and Radiation Experiment (EUCREX) is presented.
An objective spinal motion imaging assessment (OSMIA): reliability, accuracy and exposure data
Authors: Breen Alan C , Muggleton Jennifer M , Mellor Fiona E 
Published: January 2006

AbstractBackgroundMinimally-invasive measurement of continuous inter-vertebral motion in clinical settings is difficult to achieve. This paper describes the reliability, validity and radiation exposure levels in a new Objective Spinal Motion Imaging Assessment system (OSMIA) based on low-dose fluoroscopy and image processing.MethodsFluoroscopic sequences in coronal and sagittal planes were obtained from 2 calibration models using dry lumbar vertebrae, plus the lumbar spines of 30 asymptomatic volunteers. Calibration model 1 (mobile) was screened upright, in 7 inter-vertebral positions. The volunteers and calibration model 2 (fixed) were screened on a motorised table comprising 2 horizontal sections, one of which moved through 80 degrees. Model 2 was screened during motion 5 times and the L2-S1 levels of the volunteers twice. Images were digitised at 5fps.Inter-vertebral motion from model 1 was compared to its pre-settings to investigate accuracy. For volunteers and model 2, the first digitised image in each sequence was marked with templates. Vertebrae were tracked throughout the motion using automated frame-to-frame registration. For each frame, vertebral angles were subtracted giving inter-vertebral motion graphs. Volunteer data were acquired twice on the same day and analysed by two blinded observers. The root-mean-square (RMS) differences between paired data were used as the measure of reliability.ResultsRMS difference between reference and computed inter-vertebral angles in model 1 was 0.32 degrees for side-bending and 0.52 degrees for flexion-extension. For model 2, X-ray positioning contributed more to the variance of range measurement than did automated registration. For volunteer image sequences, RMS inter-observer variation in intervertebral motion range in the coronal plane was 1.86 degreesand intra-subject biological variation was between 2.75 degrees and 2.91 degrees. RMS inter-observer variation in the sagittal plane was 1.94 degrees. Radiation dosages in each view were below the levels recommended for a plain film.ConclusionOSMIA can measure inter-vertebral angular motion patterns in routine clinical settings if modern image intensifier systems are used. It requires skilful radiography to achieve optimal positioning and dose limitation. Reliability in individual subjects can be judged from the variance of their averaged inter-vertebral angles and by observing automated image registration.
Water Resistance and Durability of Weather-Resistive Barriers
Authors: Weston TA , Pascual X , Boone K 
Published: January 2006

Abstract
Weather resistive barriers function as the second line of defense against water that has intruded past a building's cladding. Despite its importance, however, the evaluation of weather-resistive barrier water resistance performance is not conducted in a consistent manner across product types. Several different test methods that include vastly different water exposure techniques are used. Because of the variance in test methods and rating systems, the selection of optimal weather resistive barrier for a specific project can be difficult. Complicating matters further, the water resistance of weather resistive barriers is almost always reported on as-received materials, with little if any information provided on how the water resistance will change during the construction period or in service. This paper presents data comparing the water resistance of weather resistive barriers measured by both standard methods and by a small-scale water spray test. Additionally, the change in water resistance performance due to direct environmental exposure is discussed.
International Standards for Blast Resistant Glazing
Authors: Johnson NF 
Published: January 2006

Abstract
Glass fragments are a prime source of injury to occupants of buildings subjected to an explosive event. Health and safety considerations and the principles of a “reasonable duty of care” impose requirements on employers and on the designers and managers of buildings. Two International Standards have been prepared for the test and classification of “Glass in building—Explosion resistant security glazing.” These incorporate three test regimes. One standard employs a shock tube method to simulate the blast from large vehicle bombs. The other standard involves two categories of arena tests using live explosives at varying distances. One test series uses small, hand-carried charges of up to 20 kg weight and the other is based upon the blast from 100 kg TNT equivalent vehicle bomb charges, where TNT refers to trinitrotoluene. The three test regimes and classifications are described and compared. The paper demonstrates how the Standards will facilitate the specification, design, and testing of glass and complete glazing systems having compositions from antishatter film applications through to thick and bullet resistant laminated glass. The tests are appropriate for other building components and the Standards will offer a valuable tool to provide safer buildings with blast resistance for protection or hazard reduction.
Evaluation of a Curriculum for Intimate Partner Violence Screening in a Pediatric Emergency Department
Authors: Knapp Jane F. , Dowd M. Denise , Kennedy Christopher S. , Stallbaumer-Rouyer Jennifer , Henderson Deborah P. 
Published: January 2006

OBJECTIVE. We sought to describe the assessment of course participant changes in attitudes, self-efficacy, and behaviors after completion of the Its Time to Ask training curriculum for screening for intimate partner violence (IPV) in a pediatric emergency department (PED).METHODS. A 22-item Likert scale questionnaire was administered at baseline (before training), after training, and at 6-month follow-up to PED employee participants in a 2-hour IPV education program. Mean participant responses were compared between baseline/posttraining and baseline/6-month follow-up. Participants also completed a course-satisfaction survey.RESULTS. A total of 79 PED staff completed the baseline questionnaire before the training. Eighty-seven participants completed the posttraining questionnaire, and 48 completed the 6-month follow-up questionnaire. Participants had consistent, positive changes in attitudes after training that persisted at the 6-month follow-up for 5 items on the questionnaire. Attitudes that did not change showed baseline means already in disagreement with questionnaire statements. Participants reported significant, positive changes for all 7 self-efficacy statements at 1 or both of the posttraining evaluations. The only changes in behavior were observed at 6 months. The majority of participants were satisfied with the training and would recommend it to colleagues.CONCLUSIONS. Significant, self-reported changes in attitudes, self-efficacy, and behaviors/clinical practice regarding screening for IPV in a PED can be achieved through participation in a brief training curriculum.
Predicting the Risk for Sudden Infant Death Syndrome From Obstetric Characteristics: A Retrospective Cohort Study of 505011 Live Births
Authors: Smith Gordon C.S. , White Ian R. 
Published: January 2006

OBJECTIVE. We sought to develop a simple robust method for assessing the risk for sudden infant death syndrome (SIDS) on the basis of obstetric characteristics.
METHODS. A population-based retrospective cohort study was conducted of data from the linked Scottish Morbidity Record, Stillbirth and Infant Death Enquiry and General Registrar's Office database of births and deaths, encompassing births in Scotland between 1992 and 2001. All women who had a singleton live birth between 24 and 43 weeks' gestation and for whom data were available (n = 505011), divided into model development and validation samples, were studied. The main outcome measure was death of the infant in the first year of life as a result of SIDS.
RESULTS. The risk for SIDS was modeled in the development sample using logistic regression with the following predictors: maternal age, parity, marital status, smoking, and the birth weight and the gender of the infant. When the model was evaluated in the validation sample, the area under the receiver operating characteristic curve was 0.84 and the incidence of SIDS was 0.7 per 10000 (95% confidence interval: 0.3–1.4) among 126253 women in the lower 50% of predicted risk and 29.7 per 10000 (95% confidence interval: 23.4–37.2) among the 25250 women in the top 10% of predicted risk. A logistic-regression model then was developed for the whole population, and the output was converted into adjusted likelihood ratios. These are tabulated and provide a simple method for assessing the risk for SIDS associated with any combination of obstetric characteristics.
CONCLUSIONS. A model that uses maternal characteristics and outcome at birth is predictive of the risk for SIDS. This model is presented in a simple form that allows calculation of the individual risk for SIDS.
Quality of Life for Children With Functional Abdominal Pain: A Comparison Study of Patients' and Parents' Perceptions
Authors: Youssef Nader N. , Murphy Thomas G. , Langseder Annette L. , Rosh Joel R. 
Published: January 2006

OBJECTIVE. Children with chronic abdominal pain of nonorganic origin, termed functional abdominal pain (FAP), experience school absences and social withdrawal and report impaired physical ability. The aim of this study was to assess patients' and parents' perceptions of health-related quality of life (QoL) for children with FAP.
METHODS. Between October 2002 and November 2003, 209 children (including 125 girls; age: 11.2 ± 3.5 years) and 209 parents were recruited from a pediatric referral center. At the time of their initial evaluations, participants completed a validated, health-related QoL instrument (Pediatric Quality of Life Inventory), which was scored on a scale of 0 (poor) through 100 (best). Children with FAP (n = 65) and their families were compared with control groups of healthy children (n = 46) and children with histologically proven inflammatory bowel disease (IBD) (n = 42) or gastroesophageal reflux disease (GERD) (n = 56).
RESULTS. Children with FAP had self-reported QoL scores (score: 78) that were similar to those for children with GERD (score: 80) or IBD (score: 84). Children with FAP had lower QoL scores than did healthy children (score: 88). Parents of children with FAP reported lower QoL scores, compared with their children's scores (scores: 70 vs 78).
CONCLUSIONS. Children with FAP reported lower QoL, compared with their healthy peers, and had the same QoL scores as did children with IBD or GERD. Parents' perceptions of QoL for children with FAP were lower than their children's self-reported scores. These findings highlight the clinical significance of FAP and may provide insight into one facet of the disease's biopsychosocial etiology.