bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐Scale Intense Geoelectric and Geomagnetic Field Perturbations Observed After an Interplanetary Magnetic Field Turning
Authors: Shi Xueling , Hartinger Michael D. , Zou Ying , Rigler E. Joshua , Weygand James M. , Kelbert Anna , Lucas Greg M. , Baker Joseph B. H. , Angelopoulos Vassilis 
Published: February 2025

AbstractIntense geoelectric fields during geomagnetic storms generate geomagnetically induced currents in power grids and other infrastructure, necessitating an understanding of their causes, for example, through coordinated space and ground observations. This study investigates localized intense geoelectric (E) and geomagnetic (B) field perturbations following an Interplanetary Magnetic Field (IMF) turning during a geomagnetic storm on 25 October 2011. Observations from EarthScope magnetotelluric sites in the upper Midwest United States revealed shorter period (1 min) ultra‐low‐frequency (ULF) waves superimposed on longer period (10 min) perturbations in both E and B fields. These sites, located at 19 hr magnetic local time and magnetic latitude, recorded large amplitude E and B perturbations. Ground‐based all‐sky imagers showed auroral brightening with sunward and poleward propagation, while upstream spacecraft linked the perturbations to an IMF turning and solar wind dynamic pressure impulse. The longer‐period E and B field perturbations likely stem from localized ionospheric currents tied to substorm auroral activity post‐IMF turning. The combination of ionospheric currents, ULF waves, and the Earth's varying conductivity produces intense geoelectric fields of 2 V/km in the upper Midwest. A comparison using input data and software compatible with the NOAA/USGS geoelectric field nowcast model revealed its limitations in capturing such events due to the temporal and spatial resolution of the underlying data. Using 1‐s geomagnetic field data can improve geoelectric field models by capturing short‐period and large spatial scale waves, although localized magnetic perturbations remain underestimated due to insufficient ground magnetometer density.
Thermochronology of the Western Alps (Pelvoux Massif) Reveals the Longterm Multiphase Tectonic History of the European Paleomargin
Authors: Boschetti L. , Mouthereau F. , Schwartz S. , Rolland Y. , Bernet M. , Balvay M. , Cogné N. , Lahfid A. 
Published: February 2025

AbstractThe Variscan and Alpine long‐term thermal evolution of the European paleomargin in the external Western Alps is still unknown, although important for reconstructing the geodynamic evolution of this orogen. Here we combine zircon fission track and apatite fission track and U‐Pb double dating analyses of the Pelvoux massif in the Western Alps. Apatite U‐Pb ages of <310 Ma and >320 Ma define a bimodal age distribution that reflects differential cooling across the East Variscan Shear Zone. QTQt thermal history modeling reveals a two‐stage rifting evolution on the European paleomargin, initiated with the Alpine Tethys rifting episode during the Early Jurassic and reactivated during the Cretaceous Valais rifting event, leading to peak temperatures of ∼350°C at 90 Ma. The subsequent cooling records a pre‐Priabonian phase of exhumation between 80 and 50 Ma that is related to N‐S oriented Pyrenean shortening. It is followed by Alpine collision‐related burial of the Pelvoux massif from below the foreland basin and the Penninic Frontal Thrust at around 30–25 Ma.
Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6
Authors: Woelk Johannes , Hornsteiner Florian , Aschauer-Wallner Stephanie , Stoitzner Patrizia , Baier Gottfried , Hermann-Kleiter Natascha 
Published: February 2025

Abstract
Natural killer (NK) cell development and functionality rely on precise regulation by specific transcription factors (TFs). Our study demonstrates that the nuclear orphan receptor NR2F6 represses the expression of the activating receptor NKp46, an established key player in NK cell-mediated cytotoxicity during infection and tumor rejection. Despite normal NK cell development in the bone marrow, germline Nr2f6-deficient mice exhibit impaired terminal maturation of NK cells in the periphery. Short-term NK cell responses to lipopolysaccharide (LPS) activation, independent of NKp46, are subsequently reduced in Nr2f6-deficient mice. Conventional type 1 dendritic cells (cDC1) and macrophage populations are decreased in spleens of Nr2f6-deficient mice, subsequently, IL-15-dependent NK cell priming is limited. Administration of exogenous IL-15 in vitro and as IL-15 complex in vivo can compensate for these deficits, promoting terminal maturation of NK cells in Nr2f6-deficient mice. Subsequent transcriptome analysis reveals significant changes in gene expression profiles of NK cells from IL-15 complex treated Nr2f6-deficient mice, with notable alterations in essential NK genes such as Klrg1, Prdm1, Stat5a, Zeb2, and Prf1. Consequently, Nr2f6-deficient IL-15 complex-treated NK cells raise enhanced effector responses of IFNγ, Perforin, and Granzyme B upon ex vivo activation. Of importance, Nr2f6-deficient mice are protected against MHC-I negative B16-F10 melanoma lung metastasis formation, especially with IL-15 complex treatment, indicating the potential of NR2F6 to affect NKp46-dependent NK cell-mediated tumor surveillance. The therapeutic targeting of NR2F6 may be a promising strategy for boosting NKp46-dependent NK-cell-mediated tumor surveillance and metastasis.
Targeting MDM2 affects spastin protein levels and functions: implications for HSP treatment
Authors: Sardina Francesca , Polverino Federica , Valentini Sonia , Carsetti Claudia , Falvo Elisabetta , Tisci Giada , Soddu Silvia , Moretti Fabiola , Paiardini Alessandro , Rinaldo Cinzia 
Published: February 2025

Abstract
Spastin is a microtubule (MT) severing enzyme that regulates several cell functions associated with MT dynamics. A reduction in spastin protein levels is responsible for approximately 40% of cases of Hereditary Spastic Paraplegia (HSP), a neurodegenerative disease. Currently, there is no cure for HSP but strategies to induce a recovery of spastin levels are emerging as potential therapeutic approaches. Here, we show that MDM2 interacts with spastin MT-interacting and trafficking (MIT) domain. By biochemical and functional experiments, we demonstrate that MDM2 binds spastin and regulates its levels in a post-transcriptional manner independently of the E3 ubiquitin ligase activity. Of relevance, treatment of spastin-deficient cells with the MDM2 inhibitor Nutlin-3a can restore spastin levels and functions, such as cytokinetic abscission and sorting of transferrin receptor. These findings identify MDM2 as a novel interactor of spastin and a potential druggable regulator of its protein levels.
Periodic splay Fréedericksz transitions in a ferroelectric nematic
Authors: Basnet Bijaya , Paladugu Sathyanarayana , Kurochkin Oleksandr , Buluy Oleksandr , Aryasova Natalie , Nazarenko Vassili G. , Shiyanovskii Sergij V. , Lavrentovich Oleg D. 
Published: February 2025

Abstract
Electric field-induced splay of molecular orientation, called the Fréedericksz transition, is a fundamental electro-optic phenomenon in nonpolar nematic liquid crystals. In a ferroelectric nematic NF with a spontaneous electric polarization

$${{\bf{P}}}$$

P

, the splay is suppressed since it produces bound electric charges. Here, we demonstrate that an alternating current (ac) electric field causes three patterns of NF polarization. At low voltages,

$${{\bf{P}}}$$

P

oscillates around the field-free orientation with no stationary deformations. As the voltage increases, the polarization acquires stationary distortions, first splay and twist in a stripe pattern and then splay and bend in a square lattice of +1 and -1 defects. In all patterns,

$${{\bf{P}}}$$

P

oscillates around the stationary orientations. The stationary bound charge is reduced by a geometrical “splay cancellation” mechanism that does not require free ions: the charge created by splay in one plane is reduced by splay of an opposite sign in the orthogonal plane.
Reach&Grasp: a multimodal dataset of the whole upper-limb during simple and complex movements
Authors: Di Domenico Dario , Forsiuk Inna , Müller-Cleve Simon , Tanzarella Simone , Garro Florencia , Marinelli Andrea , Canepa Michele , Laffranchi Matteo , Chiappalone Michela , Bartolozzi Chiara , De Michieli Lorenzo , Boccardo Nicolò , Semprini Marianna 
Published: February 2025

Abstract
Upper-limb movement characterization is crucial for many applications, from research on motor control, to the extraction of relevant features for driving active prostheses. While this is usually performed using electrophysiological and/or kinematic measurements only, the collection of tactile data during grasping movements could enrich the overall information about interaction with external environment. We provide a dataset collected from 10 healthy volunteers performing 16 tasks, including simple movements (i.e., hand opening/closing, wrist pronation/supination and flexion/extension, tridigital grasping, thumb abduction, cylindrical and spherical grasping) and more complex ones (i.e., reaching and grasping). The novelty consists in the inclusion of several types of recordings, namely electromyographic -both with bipolar and high-density configuration, kinematic-both with motion capture system and a sensorized glove, and tactile. The data is organized following the Brain Imaging Data Structure standard format and have been validated to ensure its reliability. It can be used to investigate upper-limb movements in physiological conditions, and to test sensor fusion approaches and control algorithms for prosthetics and robotic applications.
Biomass derived carbon/platinum nanoparticles as electrocatalyst for the hydrogen evolution
Authors: Ali Shimaa M. 
Published: February 2025

Abstract
Green hydrogen is gaining a significant attention in the transition to sustainable energy and achieving net-zero emissions. Platinum-based catalysts are highly regarded in hydrogen production, particularly due to their efficiency in water electrolysis. Platinum nanoparticles (Pt NPs) is successively prepared by the microwave-assistant citrate method on a biomass-based support, and characterized by X-rays diffraction, scanning and transmission electron microscopy. The chelation and gelation resulted by using citric acid during the synthesis lead to the formation of highly stabilized and dispersed Pt NPs on the carbon support. The electrocatalytic activity of Pt NPs for the hydrogen evolution reaction (HER) is examined by cathodic linear polarization and impedance spectroscopy. A high catalytic performance is shown by the prepared sample, as indicated by the calculated exchange current density 5.3 mA/cm2, and activation energy, 38.13 kJ/mol. The HER follows Volmer/Tafel mechanism with a reaction order of unity. Impedance spectra confirms the high electrocatalytic activity by the decrease of the total impedance, pore resistance, and charge-transfer resistance, with increasing the applied overpotential. The proposed synthesis method offers a green, economic, and efficient route for preparing precious metals used for catalytic applications.
A bivariate multifractal analysis approach to understanding socio-spatial segregation dynamics
Authors: Lengyel Janka , Roux Stéphane G. , Bonin Olivier , Jaffard Stéphane , Abry Patrice 
Published: February 2025

Abstract
Although the study of multifractal properties is now an established approach for the statistical analysis of urban data, the joint multifractal analysis of several spatial signals remains largely unexplored. The latter is crucial for understanding complex multiscale relationships in cities, such as socio-spatial segregation processes, where the evolution of behavior across geographical scales traditionally plays a central role. In this context, the proposed approach, which uses wavelet leaders for multifractal analysis of irregular point processes, estimates self-similarity and intermittency exponents as well as self-similar and multifractal cross-correlation by combining classical multifractal and geographic analysis methods. Results show that a local bivariate multifractal analysis can not only be related to classical two-group segregation indices but also extends them to provide a robust analytical framework that (1) is less susceptible to the modifiable areal unit problem and normalization methods and that (2) can reveal more pronounced evolution across spatial scales. In addition, multifractal analysis (3) can also delineate more “perturbed” areas in which the dominance of one group is occasionally interrupted by local concentrations of the other group, referred to here as intermittent segregation.
Impact of Ag2O on physical and electrical properties of Li2O-MgO-Bi2O3-SiO2 glass system as promising solid state electrolytes
Authors: Abo-Mosallam Hany A. , Ibrahim Samia E. 
Published: February 2025

Abstract
The intrinsic aim of this work is to understand the influence of composition change on the physical-electrical parameters of glasses with the composition (20-Y) Li2O-YAg2O–20MgO–10Bi2O3-50SiO2 (Y = 0.25, 0.5, 1.0, 2.0 and 4.0 mol%). The results of the physical parameters indicate a growth in the strength of the glass structure with the increase replacement of Li2O by Ag2O. However, the decrease in loss factor ε″, and AC conductivity σ

ac
of glasses may be attributed to the decrease in the space charge polarization (scp). AC conductivities exhibit simple power law variation. The s values essentially lie in the range of 0.67–0.92, which is typical of conductors in Jonscher regime. Dielectric properties (constant ε′, loss ε″ and ac conductivity σac, over a range of frequency 100–100 kHz and temperature RT (Room Temperature)–200 °C and frequency exponent s) of these glasses have been studied The results indicate a great potential of the prepared glasses as promising materials that can be used for solid state electrolytes.
Contrary trends of grout consumption and water absorption at Sardasht
Authors: Nazari Mohammad Hassan , Aalianvari Ali , Tani Mohamed El 
Published: February 2025

Abstract
A new interpretation of contrary trends of water absorption rate and cement mix consumption in rock grouting is presented. The classical interpretation is either a higher consumption due to fracturing or a higher absorption due to thin fractures that cannot be grouted. Higher grout consumption will depend on the distribution of fractures, their openings and extensions. This is proven by a time simulation of grouting data recorded at Sardasht dam. The simulation is made considering analytic tools and a spreadsheet with computation capabilities. The first step is to prove that the rock has been permeated and the second step is to differentiate the causes of consumption. The minimal flow criterion is integrated to the investigation and is necessary to define a frame for the comparison. Over consumption happens when ignoring the relation between the target and closure.
A flexible way to study composites in ecology using structural equation modeling
Authors: Yu Xi , Schuberth Florian , Henseler Jörg 
Published: February 2025

Abstract
Composites, which refer to weighted linear combinations of variables, are receiving increasing attention in the field of ecology. In practice, however, researchers relying on the common approaches to study composites encounter limitations in flexibly specifying composites with structural equation modeling (SEM). To enrich the researchers’ statistical toolbox and to flexibly model composites in structural equation models, we introduce the Henseler–Ogasawara (H–O) specification to the field of ecology. As we show in this paper, this approach can not only mimic the common approaches such as the one-step and two-step approaches, but also offers improvements. Compared to the two-step approach, the H–O specification explicitly models composites, i.e., it takes into account the formation of the composites and it allows modeling composites with free weights and with fixed weights, i.e., unknown-weight and fixed weight composites. Consequently, this specification allows for a more in-depth model assessment. Compared to the one-step approach, the H–O specification offers more modeling flexibility. For example, it allows researchers to specify the effects of other variables on a composite. Consequently, conceptual models can be more adequately represented by the statistical model using this specification. To demonstrate these advantages, we provide an ecological illustrative example including the R code to reproduce our results. Specifically, we present different H–O specifications and compare them statistically. Our analysis also shows that the specified model, closest to the conceptual model of the illustrative example does not adequately describe the data. Instead, a model that does not assume that all covariances between the components of the composites are accounted for by the composites fits the data well.
Mitigating effects of Jiawei Chaihu Shugan decoction on necroptosis and inflammation of hippocampal neurons in epileptic mice
Authors: Wang Qin , Qin Baijun , Yu Han , Zeng Jiawei , Fan Jingjing , Wu Qiong , Zeng Rong , Yu Haichun , Zhang Xian , Li Mingfen , Zhou Yanying , Diao Limei 
Published: February 2025

Abstract
Jiawei Chaihu Shugan decoction (JWCHSGD) is a traditional Chinese medicine well-known for its beneficial effects in treating epilepsy (Xianzheng in ancient Chinese), but the molecular mechanism of its action remains unclear. To investigate the molecular mechanism of JWCHSGD’s prevention of epilepsy-mediated neuron from necroptosis and inflammation via the circRNA-Csnk1g3/Csnk1g3-85aa/ CK1γ3/TNF-α signal pathway. In vitro, murine neuronal HT22 cells were treated in six groups: control, model, carbamazepine, and three JWCHSGD doses (high, medium, low). Viability and apoptosis were assessed via CCK-8 and flow cytometry. In vivo, 60 C57BL/6J mice were divided into six groups: control, model, carbamazepine, JWCHSGD, JWCHSGD + Sh Circ_Csnk1g3, and JWCHSGD + Sh NC. An epilepsy model was induced, and treatments were administered for two weeks. Outcomes included EEG, hippocampal histopathology, apoptosis (TUNEL), and mRNA/protein expression of key pathway markers. In HT22 cells, the model group showed reduced viability, increased apoptosis, and elevated mRNA/protein levels of Csnk1g3-85aa, RIP1, RIP3, MLKL, TNF-α, IL-6, and IL-1β (P < 0.05). JWCHSGD and carbamazepine increased viability and decreased apoptosis, reversing these molecular changes (P < 0.05). In mice, the model group had heightened epileptic discharges, neuronal damage, and apoptosis, along with increased expression of the same markers (P < 0.05). JWCHSGD and carbamazepine mitigated these effects (P < 0.05). JWCHSGD reduces epileptic events by regulating the circRNA-Csnk1g3/Csnk1g3-85aa/CK1γ3/TNF-α signaling pathway, impacting necroptosis and inflammation in hippocampal neurons and HT22 cells.
Quantity and Complexity of Speech-Language Pathologists' Talk During School-Based Therapy
Authors: Sun Jing , Justice Laura M. , Jhuo Rong-An , Jiang Hui 
Published: February 2025

Purpose:
This study examined the quantity and complexity of speech-language pathologists' (SLPs') talk during therapy with school-aged children and explored the extent to which SLP- and session-level characteristics contribute to the variability in SLP talk quantity, grammatical complexity, and lexical complexity during therapy.

Method:
We used secondary data collected from 209 business-as-usual therapy session recordings collected in the fall of the school year involving 75 SLPs and 281 kindergarten, first-, and/or second-grade students. Students were receiving services for language disorder and had therapy goals targeting various domains of language. SLP talk was coded to capture various aspects of quantity and complexity.

Results:
SLPs with more years of experience tended to produce a lower quantity of talk, whereas higher levels of time pressure were associated with increased quantity of talk as well as grammatical and lexical complexity. In addition, session length, mean age of children, and children's phonological awareness scores were significantly associated with SLP talk quantity, grammatical complexity, and lexical complexity.

Conclusions:
This study adds to the evidence for the variability of SLP talk. SLP talk quantity and complexity are related to SLPs' years of experience and time pressure. Session-level predictors suggest grouping strategies for therapy sessions.
Correlation between imaging features and rEm18 antibodies in alveolar echinococcosis: results from a multicenter study in France
Authors: Simon Gabriel , Grenouillet Frédéric , Richou Carine , Delabrousse Eric , Blagoskonov Oleg , Minello Anne , Thiefin Gerard , Frentiu Emilia , Wallon Martine ,   EchinoVISTA Group, Bresson-Hadni Solange , Calame Paul 
Published: February 2025

Background: To correlate imaging features of alveolar echinococcosis (AE) with the antibodies to recombinant Em18 (rEm18AB) at diagnosis and evaluate initial imaging features associated with serologic response, this retrospective study used data from the prospective multicenter EchinoVISTA study (NCT02876146). Imaging and serology were performed at diagnosis and during follow-up. Univariate and multivariate analyses were used to evaluate imaging features associated with the rEm18AB index. Follow-up analyses evaluated the imaging features associated with serologic response (defined as a 50% reduction in the baseline value within 2 years) in non-operated patients treated with albendazole alone. Results: From June 2012 to July 2016, 45 patients were included, with 8/45 (18%) having an rEm18AB index < 1. Maximum lesion size (76 mm [IQR = 57–93] vs. 36 mm [IQR = 26–51], p = 0.006), microcyst percentage (70% [IQR = 3–8] vs. 20% [IQR = 0.5–3.5], p = 0.004), and maximum standardized uptake value (SUV) on fluorodeoxyglucose positron emission tomography (5.1 [IQR = 4.4–6.2] vs. 2.6 [IQR = 2.4–3.9], p = 0.001) were associated with an rEm18AB index > 1. In patients treated with albendazole, serologic responders at 2 years had smaller lesions (5.3 [IQR = 3.8–72] vs. 3.5 [IQR = 2.7–3.7], p = 0.010) with less pedicle involvement, and lower initial rEm18AB index (2.98 ± 1.63 vs. 7.81 ± 3.95, p = 0.011). Conclusion: Maximum lesion size, percentage of microcysts within the lesion, and maximum lesion SUV are significant imaging features of AE correlated with the rEm18AB index. Serologic response at 2 years occurs primarily in patients with small lesions and a low rEm18AB index.