bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report: Acquired resistance to crizotinib from a MET Y1230H mutation in a patient with non-small cell lung cancer and KIF5B-MET fusion
Authors: Dong Su-Su , Dong Wen , Tan Ya-Fen , Xiao Qiang , Wang Tian-Li 
Published: April 2024

BackgroundThe c-met proto-oncogene (MET) serves as a significant primary oncogenic driver in non-small cell lung cancer (NSCLC) and has the potential to fuse with other genes, such as KIF5B, although it occurs infrequently. Only a limited number of reported cases have examined the clinical efficacy of crizotinib in patients with KIF5B-MET gene fusion, with no known data regarding acquired resistance to crizotinib and its potential mechanisms. In this report, we present the clinical progression of a female patient diagnosed with NSCLC and harboring a KIF5B-MET gene fusion.Case descriptionThe patient initially exhibited partial response to first-line crizotinib treatment, albeit for a short duration and with limited efficacy. Subsequent disease progression revealed the emergence of a secondary MET mutation, specifically MET Y1230H, leading to acquired resistance to crizotinib.ConclusionThe reporting of this case is imperative for informing clinical practice, given the uncommon occurrence of NSCLC with MET fusion, displaying responsiveness to MET tyrosine kinase inhibitor therapy, as well as the emergence of the secondary Y1230H alteration as a potential resistance mechanism.
The efficacy and safety of local 5-aminolevulinic acid-based photodynamic therapy in the treatment of cervical high-grade squamous intraepithelial lesion: a single center retrospective observational study
Authors: Qian Jing , Wang Yahui , Wu Guihong , Lu Junlei , Sun Liping , Xu Song 
Published: April 2024

BackgroundTypical treatments for cervical high-grade squamous intraepithelial lesion (HSIL) are invasive procedures. However, these procedures often come with several severe side effects, despite their positive effects on cervical HSIL. 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is a non-invasive treatment that has been successfully used to treat cervical low-grade squamous intraepithelial lesion (LSIL). In this study, we aimed to further investigate the clinical efficacy and safety of ALA-PDT in the treatment of patients with cervical HSIL.MethodsA total of 40 patients aged 20 - 41 years with cervical HSIL and high-risk Human Papilloma Virus (HR-HPV) infections were enrolled in this retrospective study from January 2019 to December 2022. Patients were treated with six times of ALA-PDT at intervals of 7–14 days. Three months after the treatment, the efficacy was evaluated through HPV genotyping and cervical cytology examination. If the cytological result was worse than ASC -US, the patient underwent colposcopy-directed biopsy immediately. Otherwise, patients would receive rigorous follow-up observation.ResultsThree months after receiving ALA-PDT treatment, 65% (26/40) of cervical HSIL patients at our center showed complete regression (cytological result: normal; HR-HPV: negative). This rate increased to 82.5% (33/40) at the 12-month follow-up. None of the patients experienced disease progression after ALA-PDT therapy. The risk of persistent HR-HPV infection was 32.5% (13/40) at the 3-month follow-up after ALA-PDT. Multivariate analyses identified cervical canal involvement as an independent risk factor for persistent HR-HPV infection at the 3-month follow-up after ALA-PDT treatment. During the treatment of the 40 patients with ALA-PDT, there were no reports of severe adverse reactions. Only a limited number of patients experienced slight discomfort symptoms.ConclusionALA-PDT is safe and effective noninvasive therapy for patients with cervical HSIL and HR-HPV infections. It is particularly suitable for young women, who have been confirmed with cervical HSIL and have demand for fertility protection. Three months after ALA-PDT treatment, if a patient still has either ASC-US cervical cytological result and/or HR-HPV infection, rigorous observation is considered safe for her. Cervical canal involvement is an independent risk factor for persistent HR-HPV infection at the 3-month follow-up after ALA-PDT treatment.
Parent-led neonatal pain management—a narrative review and update of research and practices
Authors: Ullsten Alexandra , Campbell-Yeo Marsha , Eriksson Mats 
Published: April 2024

IntroductionResearch related to parent-led neonatal pain management is increasing, as is the clinical implementation. Skin-to-skin contact, breastfeeding and parents' vocalizations are examples of pain reducing methods that give parents an opportunity to protect their infant from harm while alleviating their anxiety and developing their parenting skills.MethodsIn this paper we will provide a narrative review and describe the current research about parent-led neonatal pain management. Based on this we will discuss clinical challenges, implementation strategies and implications for future research.ResultsParents express great readiness to embrace opportunities to increase their self-efficacy in their ability to address infant pain. Parent-led pain-reducing methods are effective, feasible, cost-effective, culturally sensitive, and can be individualized and tailored to both the parent's and infant's needs. Both barriers and facilitators of parent-led pain care have been studied in research highlighting structural, organizational, educational, and intra- and interpersonal aspects. For example, health care professionals' attitudes and beliefs on parent-led methods, and their concern that parental presence during a procedure increases staff anxiety. On the other hand, the presence of a local pain champion whose duty is to facilitate the adoption of pain control measures and actively promote parent-professional collaboration, is crucial for culture change in neonatal pain management and nurses have a key role in this change. The knowledge-to-practice gap in parent-led management of infants' procedure-related pain highlight the need for broader educational applications and collaborative professional, parental and research initiatives to facilitate practice change.ConclusionParent-led neonatal pain management is more than simply a humane and compassionate thing to do. The inclusion of parent-led pain care has been scientifically proven to be one of the most effective ways to reduce pain associated with repeated painful procedures in early life and parents report a desire to participate. Focus on enablers across interprofessional, organizational and structural levels and implementation of recommended pediatric pain guidelines can support the provision of optimal evidence-based family-centered neonatal pain management.
Understanding the pubertal, psychosocial, and cognitive developmental trajectories of stunted and non-stunted adolescents: protocol of a multi-site Indonesian cohort study
Authors: Medise Bernie Endyarni , Julia Madarina , Devaera Yoga , Sitaresmi Mei Neni , Asmarinah  , Widjaja Nur Aisiyah , Kalalo Royke Tony , Soesanti Frida , Friska Dewi , Sirait Wani Riselia , Azzopardi Peter , Sawyer Susan 
Published: April 2024

BackgroundThe prevalence of stunting among Indonesian children aged 5–12 years decreased from 30.7% in 2013 to 23.6% in 2018 but has remained among the highest rates worldwide. Furthermore, Indonesian children were shorter than the standard reported by the World Health Organization and experienced obesity. The Indonesian government has created many programs to reduce stunting in children under the age of 5 years. An early preventive strategy is necessary because stunting can manifest within the initial 1,000 days of life, including during pregnancy. Therefore, a newer perspective, such as that achieved by addressing stunting in adolescents, has been deemed useful, given that adolescents are in their pubertal stage and are undergoing lifestyle changes. This cohort study was designed to measure these factors comprehensively in stunted and non-stunted children as they pass through adolescence.MethodsFor the prospective cohort, 560 individuals will be recruited from DKI Jakarta, DI Yogyakarta, and East Java. The participants will be categorized into stunted and non-stunted groups, then undergo annual examinations in which key objectives, such as weight, height, and body mass index ,will be assessed for the growth profile; waist circumference, middle-upper arm circumference, hand-grip strength, body fat percentage, and food intake will be evaluated in a nutritional assessment; psychosocial and mental issues will be evaluated according to behavioral problems, symptoms of depression, quality of life, sleep patterns, anxiety disorders, and parenting style through the use of specific questionnaires; and pubertal stage will be assessed using a self-report questionnaire. Some cross-sectional data, such as cognitive performance, hair zinc levels, vitamin D levels, bone mineral density, and bone age, will also be included. All the outcomes will be analyzed in accordance with the variable types.DiscussionThis study provides a thorough dataset of Indonesian adolescents encompassing several elements, such as growth, nutrition, psychosocial wellbeing, mental health, and pubertal development, for both stunted and non-stunted individuals. The data acquired from this study can be used to formulate policies to prevent stunting through targeted interventions for adolescents. Finally, a better understanding of adolescent health could lead to improved strategies to decrease the number of stunted individuals in the next Indonesian generation.
Day-to-day associations between mindfulness and perceived stress: insights from random intercept cross-lagged panel modeling
Authors: Borghi Olaf , Voracek Martin , Tran Ulrich S. 
Published: April 2024

ObjectiveMindfulness is frequently seen as a protective factor of stress, but self-report measures of mindfulness may overlap with other related constructs, such as mental health, and could thus not only be a predictor, but also an outcome of stress. This study thus aimed to examine the longitudinal bidirectional associations between the use and perceived helpfulness of the four mindfulness facets Observe, Describe, Nonjudge, and Nonreact with daily perceived stress.MethodsParticipants from a large (N = 1,276) mixed student and community group sample filled out a brief daily diary over the time span of 7 days. Bidirectional cross-lagged effects were investigated using the random-intercept cross-lagged panel model, an extension of the traditional cross-lagged panel model that allows to differentiate between stable between-unit differences and time-varying within-unit dynamics. In addition, we controlled for several baseline and sociodemographic confounders.ResultsAt the within-subject level, the use of Actaware was associated with higher perceived stress on the next day (β = 0.03, p = 0.029). The use (β = −0.04, p = 0.025) and perceived helpfulness (β = −0.05, p = 0.014) of Nonreact were associated with lower perceived stress on the next day. In turn, perceived stress was associated with lower perceived helpfulness of Describe (β = −0.04, p = 0.037) and Nonreact (β = −0.03, p = 0.038) on the next day. In addition, there were several residual correlations between mindfulness facets and perceived stress within days. At the between-subject level, there was a positive association between the random intercept of Describe and daily stress (r = 0.15, p = 0.003). In addition, while baseline perceived stress was negatively associated with the random intercepts of the mindfulness facets, two baseline components of mindfulness were not associated with the random intercept of perceived stress.ConclusionOn the currently investigated time scale, our results challenge prior results and assumptions regarding mindfulness as a buffering and protective factor against daily stress. With the exception of Nonreact, mindfulness was either positively associated with perceived stress, or in turn perceived stress appeared to interfere with the ability to stay mindful in daily life.
When people start getting real: The Group Living Skills Survey for extreme work environments
Authors: Landon Lauren Blackwell , Miller Jennifer C. W. , Bell Suzanne T. , Roma Peter G. 
Published: April 2024

IntroductionGroup living skills (GLS), that is, being tidy and considerate of others, are an important skillset for teams who live and work together. However, this construct does not have a validated measure to enable an understanding of how group living skills influence team dynamics over time. We developed and validated a short measure of group living skills for teams living in extreme work environments.MethodsWe collected data from 83 individuals in 24 teams living and working in space and spaceflight analog environments on missions of 45–240 days.ResultsWe provide evidence of reliability and validity for the GLS Survey over time and identify a two-factor structure. We also demonstrate its use as a measure of team-level dynamics and its utility as a sociometric measure to identify a person’s degree of group living skills.DiscussionWe outline recommendations for using this new measure in future research and applied settings to understand this unique aspect of teams living and working together.
Evaluation of biological markers for the risk assessment of carbon black in epidemiological studies
Authors: Yong Mei , McCunney Robert J. 
Published: April 2024

Background/objectivesEngineered nanomaterials (ENMs) have been suggested as being capable of promoting inflammation, a key component in the pathways associated with carcinogenesis, cardiovascular disease, and other conditions. As a result, the risk assessment of biological markers as early-stage indicators has the potential to improve translation from experimental toxicologic findings to identifying evidence in human studies. The study aims to review the possible early biological changes in workers exposed to carbon black (CB), followed by an evidentiary quality evaluation to determine the predictive value of the biological markers.MethodsWe conducted a literature search to identify epidemiological studies that assessed biological markers that were involved in the inflammatory process at early stages among workers with exposure to CB. We reviewed the studies with specific reference to the study design, statistical analyses, findings, and limitations.ResultsWe identified five Chinese studies that investigated the potential impact of exposure to CB on inflammatory markers, bronchial wall thickening, genomic instability, and lung function impairment in CB production workers. Of the five Chinese studies, four were cross-sectional; another study reported results at two-time points over six years of follow-up. The authors of all five studies concluded positive relationships between exposure and the inflammatory cytokine profiles. The weak to very weak correlations between biomarkers and early-stage endpoints were reported.ConclusionMost inflammatory markers failed to satisfy the proposed evidentiary quality criteria. The significance of the results of the reviewed studies is limited by the cross-sectional study design, inconsistency in results, uncertain clinical relevance, and high occupational exposures. Based on this review, the risk assessment relying on inflammatory markers does not seem appropriate at this time. Nevertheless, the novel research warrants further exploration in assessing exposure to ENMs and corresponding potential health risks in occupational settings.
High-Throughput Screening Method Using Escherichia coli Keio Mutants for Assessing Primary Damage Mechanism of Antimicrobials
Authors: Martínez-Álvarez José A. , Vicente-Gómez Marcos , García-Contreras Rodolfo , Wood Thomas K. , Ramírez Montiel Fátima Berenice , Vargas-Maya Naurú Idalia , España-Sánchez Beatriz Liliana , Rangel-Serrano Ángeles , Padilla-Vaca Felipe , Franco Bernardo 
Published: April 2024

The Escherichia coli Keio mutant collection has been a tool for assessing the role of specific genes and determining their role in E. coli physiology and uncovering novel functions. In this work, specific mutants in the DNA repair pathways and oxidative stress response were evaluated to identify the primary targets of silver nanoparticles (NPs) and their mechanism of action. The results presented in this work suggest that NPs mainly target DNA via double-strand breaks and base modifications since the recA, uvrC, mutL, and nfo mutants rendered the most susceptible phenotype, rather than involving the oxidative stress response. Concomitantly, during the establishment of the control conditions for each mutant, the katG and sodA mutants showed a hypersensitive phenotype to mitomycin C, an alkylating agent. Thus, we propose that KatG catalase plays a key role as a cellular chaperone, as reported previously for the filamentous fungus Neurospora crassa, a large subunit catalase. The Keio collection mutants may also be a key tool for assessing the resistance mechanism to metallic NPs by using their potential to identify novel pathways involved in the resistance to NPs.
Isolation and Identification of Chicken-Derived Lactic Acid Bacteria: In Vitro Probiotic Properties and Antagonistic Effects against Salmonella pullorum, Staphylococcus aureus, and Escherichia coli
Authors: Tian Congcong , Wang Lei , Liu Mengjian , Liu Jiancheng , Qiu Mingxin , Chen Yong 
Published: April 2024

The development of probiotics capable of quickly colonizing the intestines of animals is important in promoting the healthy growth of livestock. The aim of this study was to screen lactic acid bacteria (LAB) from the intestinal microbiota of chickens with potential applications, and to evaluate their probiotic properties and antagonistic abilities against Salmonella pullorum, Staphylococcus aureus, and Escherichia coli. The results showed that a total of 79 strains with the characteristics of LAB were isolated from the chicken cecum microbiota, of which 7 strains exhibited strong inhibitory activity against S. pullorum, S. aureus, and E. coli. Performing 16s rDNA sequencing revealed that these seven strains were Lactiplantibacillus pentosus (n = 1), Lactiplantibacillus plantarum (n = 3), Lactiplantibacillus paraplantarum (n = 1), Lactiplantibacillus argentoratensis (n = 1), and Lactiplantibacillus fabifermentans (n = 1). Among them, L. pentosus R26 and L. plantarum R32 exhibited superior antibacterial activity. These two strains demonstrated high lactic acid production ability, with survival rates of 86.29% and 87.99% after 3 h of treatment at pH 1.5, 86.66% and 85.52% after 3 h of treatment with 0.5% bile salts, 90.03% and 88.16% after 2 h of treatment with simulated gastric fluid, and 98.92% and 98.22% after 2 h of treatment with simulated intestinal fluid, respectively. Co-cultivation with L. pentosus R26 for 24 h resulted in 50% of the pathogens being antagonized, while almost complete inhibition was observed following 72 h of co-cultivation. In conclusion, L. pentosus R26 and L. plantarum R32 exhibited high antibacterial activity and acid production capability, while also demonstrating satisfactory tolerance to low pH values and high concentrations of bile salts and digestive fluid. The probiotic characteristics and stress resistance of L. pentosus R26 were slightly superior to those of L. plantarum R32, indicating its potential for development as a probiotic.
Peran Agama Kristen dalam Hubungan Internasional
Authors: Farasi Neni Gusti Endang , Nainggolan Manahan Zulkifli , Sijabat Ribka Zulkifli 
Published: April 2024

Meskipun agama tidak pernah absen dari hubungan internasional, sejak Revolusi Iran, akhir Perang Dingin, dan peristiwa 9/11, komunitas internasional telah memperbarui minatnya. Pertanyaan berpusat pada peran agama dalam perdamaian dan konflik, kesesuaian hukum dan norma agama dengan sistem pemerintahan yang berbeda, dan pengaruh aktor agama pada berbagai isu. Ketergantungan pada asumsi Pencerahan, yang menghubungkan "keagamaan" dengan yang irasional, magis, atau emosional, membuat banyak orang menganggap agama tidak pantas untuk ruang publik dan merupakan faktor kunci yang menyebabkan konflik. Di sisi lain, asumsi yang sama mengarah pada asosiasi "yang sekuler" dengan alasan, bentuk pemerintahan yang tepat, dan perdamaian. Beberapa sarjana menantang seperti kerangka dikotomi, Ilmuwan yang ingin menghindari generalisasi luas dan asumsi bermasalah tentang agama harus bergerak melampaui asumsi dan pendekatan Pencerahan yang memperlakukan komunitas, tindakan, dan gagasan agama yang beragam sebagai "baik" atau "bermasalah" secara inheren. Untuk melakukannya, para sarjana harus secara refleks terlibat dengan agama, memperhatikan asumsi ontologis mereka sendiri dan konsekuensi dari asumsi tersebut untuk analisis agama dan politik. Selain itu, para sarjana harus menempatkan praktik, prinsip, dan identitas individu dan komunitas keagamaan dalam konteks sejarah dan geografis yang lebih luas untuk memahami faktor-faktor penting yang menginformasikan kerangka etis mereka. Ada beberapa pendekatan yang memperhatikan interpretasi, praktik, dan etika, termasuk neo-Weberianisme, etika positif, teori sekuritisasi, dan pendekatan dialogis relasional. Pendekatan-pendekatan ini memberikan alternatif bagi gagasan esensial tentang agama dan menjelaskan mengapa dan bagaimana para pelaku agama memilih beberapa tindakan yang mungkin dilakukan atas yang lain.
Kata kunci—Agama, Sekularisme, Hubungan Internasional, Etika, Politik Dunia
Upaya Kerjasama Meksiko dan Amerika Serikat dalam Mengatasi Kartel Narkoba di Meksiko sebagai Transnational Organized Crime
Authors: Idris Muhammad , Togatorop Benita L 
Published: April 2024

Organisasi perdagangan narkoba ilegal yang terjadi di Meksiko sudah sampai pada batas yang membahayakan keamanan manusia disana. Pasalnya, Meksiko menjadi sumber pemenuhan kebutuhan narkotika ilegal oleh Amerika Serikat yang menyebabkan banyak kasus pembunuhan dan kekerasan yang terjadi di Meksiko maupun Amerika Serikat. Hal ini juga sangat merugikan negara, sehingga membuat Meksiko dan Amerika Serikat memutuskan untuk menjalin kerjasama bilateral dalam upaya menyelesaikan masalah penyebaran narkoba ini. Penelitian ini dibuat untuk mengetahui apa saja upaya dan langkah yang dilakukan Meksiko dalam memberantas kartel-kartel narkoba. Penelitian ini menggunakan metode kualitatif deskriptif, yang mana data didapatkan dari hasil studi literatur melalui jurnal, buku, website dan lain sebagainya. Hasil yang didapatkan akan menjelaskan seberapa besar tingkat keberhasilan upaya-upaya dari hasil kerjasama bilateral Meksiko dan Amerika Serikat untuk memberantas kartel-kartel narkoba.
Kata kunci—Amerika Serikat, Kartel Narkoba, Meksiko, Narkoba
Generation of deep levels near the 4H-SiC surface by thermal oxidation
Authors: Fujii Haruki , Kaneko Mitsuaki , Kimoto Tsunenobu 
Published: April 2024

Abstract
Deep levels near the surface of 4H-SiC after dry oxidation were investigated. A large and broad peak appeared in the low-temperature range of deep level transient spectroscopy (DLTS) spectra after oxidation of SiC at 1300 °C, indicating multiple deep levels energetically located near the conduction band edge are generated inside SiC by thermal oxidation. Analyses of the DLTS spectra acquired with changing the bias voltage revealed that the majority of deep levels is located very near the SiC surface, within about 6 nm deep region from the surface. The area density of the observed deep levels is higher than 3 × 1012 cm−2.
A high-RF-bandwidth, high-IF-bandwidth monolithic terahertz heterodyne receiver based on AlGaN/GaN nonlinear transmission lines as a local oscillator and mixer
Authors: Xiang Lanyong , Zhou Qi , Qin Chenyang , Ding Qingfeng , Zhu Yifan , Li Xinxing , Jin Lin , Shangguan Yang , Zhang Jinfeng , Sun Jiandong , Qin Hua 
Published: April 2024

Abstract
We report a monolithic heterodyne receiver that uses the AlGaN/GaN nonlinear transmission line as a local oscillator and a mixer simultaneously. This heterodyne receiver has a high RF bandwidth from 80 to 360 GHz and a high intermediate frequency bandwidth of 18 GHz. These results indicate that this nonlinear transmission line receiver has promising potential in broadband spectrum analysis.