bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dermatofibrosarcoma protuberans with regional lymph node metastasis: A case report
Authors: Hirabayashi Shinichi , Kajikawa Akiyoshi , Kanazawa Kyotaro , Mimoto Koichiro 
Published: February 2007

AbstractThe case of a 21 ‐year‐old man with dermatofibrosarcoma protuberans of the scalp that spread to deep cervical lymph nodes is presented. Available literature is reviewed, and the infrequency of metastasis is discussed. Since cases of metastases almost always involve recurrent lesions, the importance of wide and deep resection in the initial operation cannot be overemphasized.
Chemoprevention of upper aerodigestive tract cancers: A report of the third upper aerodigestive cancer task force workshop
Authors: Lippman Scott M. , Lee Jin S. , Lotan Reuben , Hong Waun K. 
Published: February 2007

AbstractThe National Cancer Institute Organ Systems Program‐sponsored Upper Aerodigestive Cancer Task Force workshops are specifically designed to enhance interactions between basic science and clinical investigators and between academic institutions and the community, and ultimately will contribute to more expeditious clinical advances. The third workshop in this series focused on the rapidly expanding area of chemoprevention of upper aerodigestive epithelial cancers. The first two sessions were devoted to discussion of in vitro and animal‐model data documenting the multistep process of squamous differentiation and carcinogenesis, associated molecular and biochemical alterations, and modulation by chemopreventive agents. Animal‐model studies have identified several promising chernopreventive agents and synergistic combinations for clinical trial. The last two sessions reviewed nutritional epidemiology, major methodologic issues of large intervention studies, and the novel concept of biologic markers as intermediate endpoints for chemoprevention trials.
Analysis of prognostic factors and proposal of a new classification for nasopharyngeal cancer
Authors: Grandi Cesare , Boracchi Patrizia , Mezzanotte Guerrino , Squadrelli Massimo , Marubini Ettore , Molinari Roberto 
Published: February 2007

AbstractA retrospective analysis was performed on 410 patients with nasopharyngeal carcinoma of squamous or undifferentiated histotype. All patients were classified according to the classification of the American Joint Committee for Cancer Staging and End‐Results Reporting (AJC) and to that of the International Union Against Cancer (UICC, Geneva, 1978). The following prognostic factors were investigated by means of a Weibull multiple regression model: sex, age, histology, primary tumor extent, and nodal metastasis extent. With the exception of sex, all factors significantly influenced survival. With regards to nodal extent, only the level of the involved nodes was a significant variable. Both AJC and UICC classifications, when applied to the entire series of patients, appeared to be unsatisfactory. The authors propose an alternative classification based on a prognostic scoring system directly derived from the Weibull model.
Toxic shock syndrome following submandibular gland excision
Authors: Fornadley John A. , Gomez Patrick J. , Crane Richard T. , Rickman Leland S. 
Published: February 2007

AbstractAcute toxic shock syndrome (TSS), initially described in association with the use of super absorbent tampons in menstruating women, has complicated a variety of surgical procedures. Recent attention in head and neck surgery has focused on absorbent packing materials, such as those used in postoperative nasal care. It is important to maintain a high index of suspicion in all postoperative patients to fever, hypotension, and erythroderma. We report TSS following submandibular gland excision.
A modified single flap for neck dissection in oral cancer
Authors: Dissanayaka Lakdasa 
Published: February 2007

AbstractModification of the single flap for neck dissection is described and illustrated based on experience with 33 cases of squamous cell carcinoma of the oral cavity. The advantages of this modified incision are that there are no three‐point junctions. Hence, it can be used after previous radiotherapy to the neck; the vertical limb is well posterior to the carotid artery, and the horizontal limb can be conveniently extended upward and forward to permit a combined resection of the jaw and/or tongue. To avoid necrosis at the apex of the skin flap, particularly after previous radiotherapy, a margin of about 1 cm can be removed prophylactically from the apex. This incision is recommended particularly for neck dissections in squamous cell carcinomas of the oral cavity in patients who have had previous radiotherapy and/or when resection of the mandible or the tongue is to be done at the same time. The incision is not recommended for bilateral neck dissections, nor for neck dissection combined with total laryngectomy or thyroidectomy.
Thyroid carcinoma presenting as a regional neck mass
Authors: Nussbaum Moses , Bukachevsky Roman 
Published: February 2007

AbstractDuring 1978‐1988, we treated 197 patients with thyroid carcinoma. Twenty‐seven patients (14.0%) presented with a regional cervical mass and a clinically normal thyroid gland on initial evaluation. Excisional biopsy proved the diagnosis of metastatic thyroid carcinoma in every patient. Subsequent thyroid scans were 42% sensitive. Only 3 patients underwent fine‐needle aspirations; none showed evidence of malignant cells. Review of surgical specimens showed total involvement of the gland in 13 of 17 cases, with extracapsular spread of tumor in 3 patients. Multicentric disease was present in all but 2 neck specimens. Patient follow‐up from 1 month to 10 years revealed an 11.5% recurrence rate. The results in this group of patients is compared to the larger group of thyroid carcinoma patients, where three recurrences were found in 170 patients presensting with a clinically palpable mass in the thyroid gland. Analysis of our population comparing the subgroup with the larger series of thyroid carcinoma patients suggests that thyroid carcinoma presenting as a regional neck mass is a more aggressive disease.
Intramuscular hemangioma of the sternomastoid muscle
Authors: Jani Piyush , Robb P. , Hanby A. M. , Gleeson M. J. 
Published: February 2007

AbstractIntramuscular hemangiomas of head and neck are uncommon benign tumors. They arise most frequently in the masseter muscle and may present a diagnostic problem. The clinical presentation is usually that of a slowly enlarging intramuscular mass. The recurrence rate is high following enucleation. A case of a rapidly evolving sternomastoid hemangioma is described which presented in unusual circumstances. The angiographic appearances of this tumor were diagnostic, and the lesion was subsequently resected completely together with a cuff or normal muscle.
Metastatic squamous cell carcinoma of the parotid: A case of an occult primary
Authors: Marvel Jeffrey B. , Schwartz Mary R. , Donovan Donald T. 
Published: February 2007

AbstractMetastatic squamous cell carcinoma involving an intraparotid lymph node, although uncommon, remains of practical consideration in the differential diagnosis of a parotid mass. This is of particular importance when the primary skin lesion is not readily identifiable, or has been inadequately managed in the past. A representative case is presented, and a review of the literature follows with special emphasis on the anatomy of the parotid lymphatics and the implications for appropriate treatment.
Multiple trichoepithelioma occluding both external auditory canals
Authors: Bibi Carmel O. , Fliss Dan M. , Avinoach Ilana , Brenner Hillel , Tovi Ferrit 
Published: February 2007

AbstractMultiple trichoepithelioma is an uncommon skin disease with autosomal dominant transmission. It is characterized by multiple, benign facial skin lesions. These lesions constitute a formidable cosmetic and therapeutic problem. Treatment modalities are numerous and varied. In a few rare cases, confluence of the lesions may result in occlusion of the auditory canal, with consequent loss of hearing. In such cases the treatment of choice should be excision and split‐thickness skin grafting.
Quantitative bacteriology of intraoperative wound tissue in contaminated surgery
Authors: Becker Gary D. , Welch William D. 
Published: February 2007

AbstractThis study was designed to evaluate the predictive value of quantitative bacteriology of intraoperative wound tissue in identifying the patient likely to develop wound infection, as well as its subsequent flora. Forty‐one patients undergoing contaminated cancer surgery of the head and neck were studied. Intraoperatively, a sample of wound tissue was cultured and anaerobic and aerobic bacterial isolates quantitated. The wound infection rate was 22% (9 of 41). There was no significant correlation between intraoperative tissue bacterial density and subsequent wound infection, or contaminating and infecting bacteria.
The accuracy and usefulness of frozen‐section diagnosis
Authors: Ikemura Kunio , Ohya Ryoichi 
Published: February 2007

AbstractA retrospective review of 57 patients, who had received frozensection diagnoses, was performed both to ascertain the accuracy of diagnosis and to evaluate its usefulness in assessing tumor surgery. Except for 2 cases, each with a parotid gland tumor, the frozen‐section diagnoses were consistent with the final diagnoses using permanent paraffin sections. Fifteen cases with either T1 or T2 squamous cell carcinoma of the oral cavity and 2 cases with malignant salivary gland tumor, showing tumor‐free surgical margins by frozen‐section examination, were followed. A local recurrence of the carcinoma was observed in 1 case during the follow‐up period. Prior to neck dissection, lymph node metastases were examined using frozen sections. Ten cases, which were diagnosed as negative for metastasis, showed no subsequent development of cervical node metastasis.
Radiation or surgery for chemodectoma of the temporal bone: A review of local control and complications
Authors: Springate Stephen C. , Weichselbaum Ralph R. 
Published: February 2007

AbstractFor a presentation to the American College of Surgeons in November 1988, we reviewed the literature concerning primary management of glomus tympanicum and jugulare tumors. From the published series, we examined the local control and treatment‐related morbidity for three therapeutic approaches: surgery alone, radiation before or after surgery, and radiation alone. The local control rates were similar, 86%, 90%, and 93%, respectively. Among the surgical series reporting complications, new cranial nerve deficits were common, especially with advanced lesions. Serious sequelae from radiation therapy were rare (2% to 3%). We feel radiation therapy should be considered as primary treatment for glomus jugulare.
Reconstruction of complex maxillectomy defects with the scapular‐free flap
Authors: Granick Mark S. , Ramasastry Sai S. , Newton E. Douglas , Solomon Mark P. , Hanna Dwight C. , Kaltman Steven 
Published: February 2007

AbstractThe defect resulting from partial or complete maxillectomy can often be reconstructed with a skin graft and a prosthesis. In situations where this simple maneuver is unsatisfactory, a more complex reconstructive modality, providing the restoration of composite tissue, is required. The scapular microvascular‐free flap was used in this series of 11 patients, as a cutaneous flap in 3 and as an osteocutaneous flap in 8, to meet the specific reconstructive needs of each patient. Excellent to satisfactory restoration of facial contour and palatal function was achieved in 10 patients. There was 1 flap failure. There were no donor site complications. Selected case histories are presented to demonstrate a spectrum of reconstructive problems. There are clear limitations to its applicability, such as the odd scapular bone contour, the thickness of the cutaneous paddle, the position change required for flap harvesting, and the risk of flap failure. The scapular flap has proven to be useful in restoring bony and soft tissue contour of the face, rigid support for the velum, oronasal separation, support for the orbit, and obliteration of the maxillary sinus. We found the scapular‐free flap to be a useful tool for reconstructing complex and variable maxillectomy defects.
Botulinum a toxin for the treatment of spasmodic torticollis: Dysphagia and regional toxin spread
Authors: Borodic Gary E. , Joseph Michael , Fay Laurie , Cozzolino David , Ferrante Robert J. 
Published: February 2007

AbstractChemodenervation of cervical muscles with botulinum A toxin, although useful in treating spasmodic torticollis, has been associated with dysphagia. Retrospective analysis of dose and injection site (sternomastoid vs. posterior cervical muscle groups) in 26 patients (49 injections) suggested that dysphagia was related to the quantity of toxin injected into the sternomastoid muscle: dysphagia, median 150 IU (7 injections); and no dysphagia, median 100 IU (42 injections; p = 0.026 Wilcoxon test). In a prospective study (31 injections to 24 patients), limiting the dose administered to the sternomastoid to 100 IU, substantially reduced the incidence of dysphagia (0 of 31, p = 0.27, Fisher's exact test).Denervation of human orbicularis muscle fibers, 5 weeks to 4 months after injection of botulinum A toxin for the treatment of blepharospasm, was successfully demonstrated by intense, diffuse acetycholinesterase staining. A weight‐adjusted dose similar to that given for torticollis was injected into longissimus dorsi muscle in 6 albino rabbits. Using the acetylcholinesterase stain as a marker, a diffusion gradient was noted over a distance of 30 to 45 mm from the point of injection and in contralateral muscle 15 to 25 mm from this point. Thus, denervation was demonstrated to occur within a definable area which crossed anatomic barriers, such as fascia and bone. These clinical and laboratory data suggest that dysphagia following botulinum toxin therapy results from toxin spread to pharyngeal musculature from the sternocleidomastoid injection site. Limiting of the injection dose to 100 IU or less to the sternomastoid substantially decreases the incidence of this complication.
Basement membrane type IV collagen in oral squamous cell carcinoma
Authors: Hirota Jyusui , Yoneda Kazunori , Osaki Tokio 
Published: February 2007

AbstractBiopsied specimens of 82 oral squamous cell carcinomas were immunohistochemically studied for detection of type IV collagen existence in the basement membrane (BM). Immunoreactivity on BM was semiquantitatively evaluated as limited (±), moderate (+), or extensive (++), and matched against clinical and histopathologic features. No clear difference in BM deposition could be found in the tumor sites. The amount of type IV collagen decreased in advanced T stage (T3 and T4) tumors. BM deposition was significantly correlated with lymph node metastasis. In 54 N‐, 32 had extensive deposition, 18 had moderate, and the remaining had limited. Conversely, only 5 of 28 N+ cases showed good type IV collagen immunoreactivity and 14 cases exhibited limited BM deposition. BM existence was also associated with the mode of invasion. BM deposition decreased in order with the grade (i.e., the more limited the BM deposition, the more diffuse the invasion mode). BM deposition was, however, not related with stromal responses, such as cellular infiltrates and fibrosis. We conclude that immunohistochemical examinations of BM deposition on biopsied specimens seem beneficial for cancer treatment.
Histologic differentiation and chemosensitivity of human head and neck squamous cell carcinomas
Authors: Nakashima Tadashi , Maehara Yoshihiko , Kohnoe Shunji , Hayashi Itsuroh , Katsuta Yasaburoh 
Published: February 2007

AbstractThe chemosensitivities of 42 human head and neck squamous cell carcinomas were examined using the in vitro succinate dehydrogenase inhibition (SDI) test. The tumor tissues obtained at surgery or biopsy were exposed to five different antitumor drugs: adriamycin (ADM), cisplatin (CDDP), carboquone (CQ), 5‐fluorouracil (5‐FU), and 1‐hexylcarbamoyl‐5‐fluorouracil (HCFU). The results were analyzed according to the histopathologic degree of differentiation of well, moderately, and poorly differentiated squamous cell carcinoma. The average decrease in succinate dehydrogenase activity was 43.2 /pm 24.9 for ADM, 29.0 /pm 14.2 for CDDP, 32.9 /pm 17.6 for CQ, 64.2 /pm 20.6 for 5‐FU, and 26.8 /pm 16.9 for HCFU. There was a statistically significant difference in the decrease of succinate dehydrogenase activity between well and poorly differentiated squamous cell carcinomas. These data suggest that, for patients with a poorly differentiated squamous cell carcinoma, the response to anticancer drugs may be more satisfactory than in those with a welldifferentiated squamous cell carcinoma.
Accessory parotid glands as a site of metastases from outside the head and neck: Case report
Authors: Goldberg Jay A. , Georgiade Gregory S. 
Published: February 2007

AbstractMetastases to the salivary glands from outside the head and neck are rare. The world literature reports 53 cases to the parotid, and 25 to the submandibular‐submaxillary gland. This is the first report of a metastasis to the accessory parotid gland.
Sternocleidomastoid flap following parotidectomy
Authors: Bugis Samuel P. , Young J. E. M. , Archibald Stuart D. 
Published: February 2007

AbstractThe sternocleidomastoid (SCM) muscle has been used in various ways for reconstruction following cancer resections in the head and neck. Its use has been restricted because of the presumed precarious nature of its blood supply and its proximity to disease. Patients with large or recurrent benign parotid tumors were the first in our series to have a SCM muscle flap (either superiorly or inferiorly based) used to improve cosmesis. After demonstrating the utility of these flaps, we extended the indications for their use to include patients with primary or recurrent malignant disease. The flaps provide soft tissue contour, coverage of facial nerves and nerve grafts, act as a healthy bed for skin grafts, and help close salivary fistulas. There were no complications attributed to the flaps. This paper discusses 31 patients with benign and malignant parotid disease in whom the SCM flap was used.
Cancer in neck nodes with unknown primary site: Role of mucosal radiotherapy
Authors: Harper Christopher S. , Mendenhall William M. , Parsons James T. , Stringer Scott P. , Cassisi Nicholas J. , Million Rodney R. 
Published: February 2007

AbstractSixty‐nine patients with metastatic squamous cell carcinoma in neck nodes with an unknown primary lesion were treated with curative intent between October 1964 and December 1986. Sixty‐five patients received radiotherapy to the neck and at least part of the mucosa of the head and neck, whereas 4 patients received treatment to the neck only. Mucosal doses were approximately 5,000 cGy‐6,000 cGy at 170 cGy‐180 cGy per fraction. Eight patients (12%) subsequently developed mucosal site failures, a figure that did not differ significantly from the incidence of a second metachronous head and neck cancer following definitive irradiation in a series of 393 patients with lesions of the supraglottic larynx, pharyngeal wall, pyriform sinus, or tonsillar area. This suggests that radiotherapy was highly effective in preventing the appearance of cancer at the unknown primary site from which the neck metastasis arose. Absolute and cause‐specific 5‐year survival rates were 48% and 66%, respectively.
Outcome of treatment of 160 patients with squamous cell carcinoma of the neck staged N3a
Authors: Isaacs John H. , Schnitman J. R. 
Published: February 2007

AbstractOne hundred sixty patients with N3a neck disease were studied to evaluate the overall treatment outcome. Of these, 54 recieved palliative radiotherapy and 106 patients were treated with treated with curative intent. Twenty patients (19%) died of inter‐current disease (13 at less than 2 years), and 13 of 93 patients followed for 2 or more years are alive with no evidence of disease. Thus, 73 patients died directly from cancer, with meta‐static disease being the leading cause of death. Almost one third of the patients failed to complete treatment.
Mandibular involvement by squamous cell carcinoma of the lower alveolus: Analysis and comparative study of histologic and radiologic features
Authors: Totsuka Yasunori , Usui Yasuhiro , Tei Kanchu , Fukuda Hiroshi , Shindo Masanobu , Lizuka Tadashi , Amemiya Akira 
Published: February 2007

AbstractHistologic analysis of squamous cell carcinoma of the lower alveolus shows 2 basic patterns of tumor spread in relation to the mandible: an infiltrative one and an expansive one. While the tumor invades the mandible by destroying the bone or through cortical defects or some spaces in the infiltrative form, the tumor does this only by eroding the bone in the expansive form, in which the degree of bone resorption seems to be proportional to tumor advancement. A comparison between radiologic and histologic features discloses that the radiologically detected bone defects are not necessarily correlated with the patterns of bone involvement. However, most lesions with erosive bone defects show the expansive pattern histologically, and the extent of the radiologically detected bone defect is roughly in accordance with the histologic extent of bone involvement. These results lead us to believe that some squamous carcinoma of the lower alveolus could be treated successfully without sacrificing the continuity of the mandible.
Results and prognosis following surgery for malignant tumors of the skull base
Authors: Jackson Ian T. , Bailey M. Hugh , Marsh W. Richard , Juhasz Peter 
Published: February 2007

AbstractA series of 155 malignant craniofacial tumors referred to a specialized craniofacial center for surgical treatment are presented. One quarter of these were primary and three quarters recurrent. The statistics of long‐term follow‐up are presented, and it is concluded that this type of surgery for these difficult problems is worthwhile. The increasing experience gained from operating on and following up these patients is presented.
Salmonellosis initially seen as a thyroid abscess
Authors: Gudipati Suhasini , Westblom T. Ulf 
Published: February 2007

AbstractA case of Salmonella typhimurium thyroid abscess in a 79‐year‐old man is reported. The patient was seen with fever and neck tenderness 2 weeks after a brief episode of diarrhea. Surgical excision combined with 2 weeks of ceftriaxone, 1 g every 12 hours, resulted in complete recovery. This is only the fourth known case of Salmonella thyroid abscess, 3 of which have been caused by S. typhimurium. This organism is rarely found in other focal Salmonella infections and may therefore have a specific affinity for thyroid tissue.
Isolated sphenoid sinus disease
Authors: Rothfield Robert E. , de Vries Rgbert J. , Rueger Raimund G. 
Published: February 2007

AbstractIsolated sphenoid sinus disease is an unusual entity that is encountered infrequently. With advances in antibiotic therapy and imaging techniques, the nature of isolated sphenoid sinus disease has significantly changed. More tumors and less inflamrnatory disorders are being encountered. We have retrospectively reviewed the medical records of patients who had undergone sublabial transseptal sphenoidotomy for isolated sphenoid sinus disease at Allegheny General Hospital for Pittsburgh between January 1985 and July 1989. Thirteen patients were identified with isolated sphenoid sinus disease who were successfully managed with sublabial transseptal sphenoidotomy. This approach allows maximal visualization and safety with minimal morbidity.