bluuebunny/crossref_metadata_2025_split huggingface dataset:
Twinning International Pediatric Cardiology Fellowship Programs: A Transformative Educational Experience for Trainees with Potential for Global Adoption
Authors: Kelleher Sean T. , Kyle William B. , Penny Daniel J. , Olsen Jillian , Nolke Lars , Allen Hugh D. , McMahon Colin J. 
Published: April 2024

Abstract
Over the last decade, having endured the COVID-19 pandemic, education and training in pediatric cardiology have undergone a profound disruptive transformation. Trainees experience considerable stress achieving all the competencies required to become a competent pediatric cardiologist. Often the quality of the training experienced by trainees, the approach to patients, and potential institutional preference in management strategy is heavily influenced by the center in which they train. We developed an online live twin program of education between Texas Children’s Hospital, Houston, Texas and Children’s Health at Crumlin Dublin Ireland in 2019. We explored using grounded theory whether a regular scheduled shared teaching program improved fellow education and training between both centers. Trainees were surveyed to evaluate the benefits and disadvantages of such a twin program. The majority (93%) found the sessions helpful from an educational standpoint with many trainees reporting it to be a transformative experience. Three important learning themes emerged: practice variation between centers, managing uncertainty in clinical practice and cognitive overload. This pedagogical model could be replicated across multiple international pediatric cardiology units and facilitate “collaborative learning” among centers across the globe. Furthermore, this novel educational model could also be adopted by other medical specialties.
Bifidobacterium modulation of tumor immunotherapy and its mechanism
Authors: Pei Bo , Peng Shixuan , Huang Chuying , Zhou Fuxiang 
Published: April 2024

AbstractThe advent of tumor immunotherapy in patients has revolutionized the treatment of tumors and significantly improved survival rates for a wide range of tumors. However, the full therapeutic potential of immune checkpoint inhibitors (ICIs) has yet to be realized, as not all patients have a lasting survival benefit from them, and a significant proportion of patients show primary or acquired resistance to immunotherapy. Bifidobacterium is one of the most common probiotics, and its antitumor and immunomodulatory effects have been demonstrated in recent years, but its immunomodulatory effects in tumors, especially on ICIs and in combination, have not been extensively studied in clinical practice, and its effects on the immune system and the mechanisms that modulate immunotherapy are largely unknown. Therefore, this review will focus on the immunomodulatory effects of Bifidobacteria in malignancies and the possible mechanisms of action of Bifidobacteria on immunotherapy in the hope of providing a basis for further research and better application of Bifidobacteria in clinical practice.
Detecting Spatial Patterns of Peatland Greenhouse Gas Sinks and Sources with Geospatial Environmental and Remote Sensing Data
Authors: Christiani Priscillia , Rana Parvez , Räsänen Aleksi , Pitkänen Timo P. , Tolvanen Anne 
Published: April 2024

AbstractPeatlands play a key role in the circulation of the main greenhouse gases (GHG) – methane (CH4), carbon dioxide (CO2), and nitrous oxide (N2O). Therefore, detecting the spatial pattern of GHG sinks and sources in peatlands is pivotal for guiding effective climate change mitigation in the land use sector. While geospatial environmental data, which provide detailed spatial information on ecosystems and land use, offer valuable insights into GHG sinks and sources, the potential of directly using remote sensing data from satellites remains largely unexplored. We predicted the spatial distribution of three major GHGs (CH4, CO2, and N2O) sinks and sources across Finland. Utilizing 143 field measurements, we compared the predictive capacity of three different data sets with MaxEnt machine-learning modeling: (1) geospatial environmental data including climate, topography and habitat variables, (2) remote sensing data (Sentinel-1 and Sentinel-2), and (3) a combination of both. The combined dataset yielded the highest accuracy with an average test area under the receiver operating characteristic curve (AUC) of 0.845 and AUC stability of 0.928. A slightly lower accuracy was achieved using only geospatial environmental data (test AUC 0.810, stability AUC 0.924). In contrast, using only remote sensing data resulted in reduced predictive accuracy (test AUC 0.763, stability AUC 0.927). Our results suggest that (1) reliable estimates of GHG sinks and sources cannot be produced with remote sensing data only and (2) integrating multiple data sources is recommended to achieve accurate and realistic predictions of GHG spatial patterns.
Prognostic value of depression and anxiety on colorectal cancer-related mortality: a systematic review and meta-analysis based on univariate and multivariate data
Authors: Xia Shijun , Zhu Yuwen , Luo Lidan , Wu Wenjiang , Ma Lijuan , Yu Linchong , Li Yue 
Published: April 2024

Abstract
Background
Depression and anxiety are common mental disorders in patients with colorectal cancer (CRC); however, it remains unclear whether they are related to cancer mortality.

Method
Based on a systematic literature search, 12 eligible studies involving 26,907 patients with CRC were included in this study.

Results
Univariate analysis revealed that anxiety was associated with an all-cause mortality rate of 1.42 (1.02, 1.96), whereas multivariate analysis revealed that anxiety was not associated with an all-cause mortality rate of 0.73 (0.39, 1.36). In univariate and multivariate analyses, depression was associated with all-cause mortality rates of 1.89 (1.68, 2.13) and 1.62 (1.27, 2.06), respectively, but not with the cancer-associated mortality rate of 1.16 (0.91, 1.48) in multivariate analyses. Multivariate subgroup analysis of depression and all-cause mortality showed that younger age (≤65 years), being diagnosed with depression/anxiety after a confirmed cancer diagnosis, and shorter follow-up time (<5 years) were associated with poor prognosis.

Conclusions
Our study emphasizes the key roles of depression and anxiety as independent factors for predicting the survival of patients with CRC. However, owing to the significant heterogeneity among the included studies, the results should be interpreted with caution. Early detection and effective treatment of depression and anxiety in patients with CRC have public health and clinical significance.
Lessons learned from revision procedures: a case series pleading for reinforcement of the anterior hiatus in recurrent hiatal hernia
Authors: Geerts Jorrit H. , de Haas Job W. A. , Nieuwenhuijs Vincent B. 
Published: April 2024

Abstract
Background
Hiatal Hernia (HH) is a common structural defect of the diaphragm. Laparoscopic repair with suturing of the hiatal pillars followed by fundoplication has become standard practice. In an attempt to lower HH recurrence rates, mesh reinforcement, commonly located at the posterior site of the esophageal hiatus, has been used. However, effectiveness of posterior mesh augmentation is still up to debate. There is a lack of understanding of the mechanism of recurrence requiring further investigation. We investigated the anatomic location of HH recurrences in an attempt to assess why HH recurrence rates remain high despite various attempts with mesh reinforcement.

Methods
A retrospective case series of prospectively collected data from patients with hiatal hernia repair between 2012 and 2020 was performed. In total, 54 patients with a recurrent hiatal hernia operation were included in the study. Video clips from the revision procedure were analyzed by a surgical registrar and senior surgeon to assess the anatomic location of recurrent HH. For the assessment, the esophageal hiatus was divided into four equal quadrants. Additionally, patient demographics, hiatal hernia characteristics, and operation details were collected and analyzed.

Results
54 patients were included. The median time between primary repair and revision procedure was 25 months (IQR 13–95, range 0–250). The left-anterior quadrant was involved in 43 patients (80%), the right-anterior quadrant in 21 patients (39%), the left-posterior quadrant in 21 patients (39%), and the right-posterior quadrant in 10 patients (19%).

Conclusion
In this study, hiatal hernia recurrences occured most commonly at the left-anterior quadrant of the hiatus, however, posterior recurrences were not uncommon. Based on our results, we hypothesize that both posterior and anterior hiatal reinforcement might be a suitable solution to lower the recurrence rate of hiatal hernia. A randomized controlled trial using a circular, bio-absorbable mesh has been initiated to test our hypothesis.
Beyond fluorescence-guided resection: 5-ALA-based glioblastoma therapies
Authors: Stummer Walter , Müther Michael , Spille Dorothee 
Published: April 2024

Abstract
Glioblastoma is the most common primary malignant brain tumor. Despite advances in multimodal concepts over the last decades, prognosis remains poor. Treatment of patients with glioblastoma remains a considerable challenge due to the infiltrative nature of the tumor, rapid growth rates, and tumor heterogeneity. Standard therapy consists of maximally safe microsurgical resection followed by adjuvant radio- and chemotherapy with temozolomide. In recent years, local therapies have been extensively investigated in experimental as well as translational levels. External stimuli-responsive therapies such as Photodynamic Therapy (PDT), Sonodynamic Therapy (SDT) and Radiodynamic Therapy (RDT) can induce cell death mechanisms via generation of reactive oxygen species (ROS) after administration of five-aminolevulinic acid (5-ALA), which induces the formation of sensitizing porphyrins within tumor tissue. Preliminary data from clinical trials are available. The aim of this review is to summarize the status of such therapeutic approaches as an adjunct to current standard therapy in glioblastoma.
The equivalence of Heegaard Floer homology and embedded contact homology via open book decompositions II
Authors: Colin Vincent , Ghiggini Paolo , Honda Ko 
Published: April 2024

AbstractThis paper is the sequel to (Colin et al. in Publ. Math. Inst. Hautes Études Sci., 2024), and is devoted to proving some of the technical parts of the HF=ECH isomorphism.
Influence of age on spatial and temporal migratory patterns of Black Storks from Germany
Authors: Fisel Felix , Heine Georg , Rohde Carsten , Wikelski Martin , Flack Andrea 
Published: April 2024

AbstractHow the migration behavior of long-lived birds develops throughout their life is still a research question in ornithology that is largely unanswered. Here, we analyzed GPS data of 70 juvenile Black Storks during the first 3 years of their migration to determine the influence of age and experience on migration patterns. We focused on the choice of the migration flyway, as well as the movements in the wintering area, and the changes in departure times with increasing age. Migratory routes of German Black Storks were divided into the western (82% of all tracked individuals) and eastern flyways (16%). The central migratory flyway through Italy or Greece was taken only by two individuals and never repeatedly. In addition, we found that the wintering area decreased by almost 60% during their first 3 years of life. In addition, spring departure dates from the wintering areas also became earlier with increasing age. However, we did not find changes in departures from the breeding area in autumn. Thus, our study shows that age and migration experiences have a considerable influence on essential migratory decisions in Black Storks. Further, it also demonstrates that older storks rely strongly on previous experiences to perform their migrations efficiently.
The effectiveness of clinical pathways in inpatient settings - an umbrella review
Authors: Büscher Anne , Kugler Joachim 
Published: April 2024

Abstract
Aim
The aim of this research is to summarize the effectiveness of clinical pathways in inpatient settings in industrialized countries to gain implications for hospital management or identify further research needs.

Subject and methods
Systematic literature reviews and meta-analyses published in English from 2010 to August 30, 2023, investigating the effectiveness of clinical inpatient pathways are identified, summarized, and synthesized. PubMed, Cochrane Library, and MEDLINE databases were searched.

Results
The search identified a total of ten systematic reviews, of which seven also conducted meta-analyses. The results show substantial heterogeneity in the data. In total, data from 140 primary studies are included. The parameters that were most frequently examined are complication rates, impact on length of stay, readmission rates, mortality, documentation quality, and hospital and care costs.

Conclusion
A positive impact of clinical pathways, including a reduced risk of complications, reduced length of stay, and a better documentation quality, can be summarized. However, the definition of the concept of clinical pathways already differs and the outcomes that were examined also differ in their definition and measurement. The results of this research on clinical pathways are not sufficient for transfer to the current situation. The results show an added value for patients, staff, and relatives, particularly for clinical pathways that involve frequent illnesses, are cost-intensive, and require a lot of communication between different professionals. Furthermore, it can be concluded that further research with randomized controlled trials is necessary to investigate the effectiveness of clinical pathways.
Therapist-Level Moderators of Patient-Therapist Match Effectiveness in Community Psychotherapy
Authors: Coyne Alice E. , Constantino Michael J. , Boswell James F. , Gaines Averi N. , Kraus David R. 
Published: April 2024

AbstractBased on patient-reported outcomes data analyzed at the provider level, there is evidence that psychotherapists can possess effectiveness strengths and weaknesses when treating patients with different presenting concerns. These within-therapist differences hold promise for personalizing care by prospectively matching patients to therapists’ historical effectiveness strengths. In a double-masked randomized controlled trial (RCT; NCT02990000), such matching outperformed pragmatically determined usual case assignment—which leaves personalized, measurement-based matching to chance—in naturalistic outpatient psychotherapy (Constantino et al., JAMA Psychiatry 78:960–969, 2021). Demonstrating that personalization can be even more precise, some research has demonstrated that the strength of this positive match effect was moderated by certain patient characteristics. Notably, though, it could also be that matching is especially important for some therapists to achieve more effective outcomes. Examining this novel question, the present study drew on the Constantino et al. (JAMA Psychiatry 78:960–969, 2021) trial data to explore three therapist-level moderators of matching: (a) effectiveness “spread” (i.e., greater performance variability across patients’ presenting problem domains), (b) overestimation of their measurement-based and problem-specific effectiveness, and (c) the frequency with which they use patient-reported routine outcomes monitoring in their practice. Patients were 206 adults, randomized to the match or control condition, treated by 40 therapists who were crossed over conditions. The therapist variables were assessed at the trial’s baseline and patients’ symptomatic/functional impairment and global distress were assessed regularly up to 16 weeks of treatment. Hierarchical linear models revealed that only therapist effectiveness spread significantly moderated the match effect for the global distress outcome; for therapists with more spread, the match effect was more pronounced, whereas the match effect was minimal for therapists with less effectiveness spread. Notably, two therapist-level covariates unexpectedly emerged as significant moderators for the symptomatic/functional impairment outcome; for clinicians who consistently treated patients with higher versus lower average severity levels and who relatedly treated a higher proportion of patients with primary presenting problems of substance misuse or violence, the beneficial match effect was even stronger. Thus, measurement-based matching may be especially potent for therapists with more variable effectiveness across problem domains, and who consistently treat patients with more severe presenting concerns or with particular primary problems, which provides further precision in conceptualizing personalized care.
Distribution models in invasive plants with climatic niche expansion: a case study of Ulex europaeus L. in Colombian Andes
Authors: Ángel-Vallejo María Camila , Aguirre-Acosta Natalia , Rodríguez-Rey Ghennie Tatiana , García-Marín Eliana Jimena , Álvarez-Mejía Luis Miguel , Feuillet-Hurtado Carolina 
Published: April 2024

AbstractInvasive plants have a wide distribution worldwide. Their ability to adapt and colonize different climates is attributed to the phenotypic plasticity and the expansion of the climatic niche of the species. Simultaneously, their distribution patterns will be affected by climate change, creating or reducing the ideal areas for their establishment. We evaluated the current and potential distribution of Ulex europaeus L. in Colombia, under the global circulation models ACCESS-ESM1-5 and MIROC6 in two scenarios, for the years 2041–2060, taking into account its climate niche expansion. An ecological niche model was built for this purpose using Maxent algorithm of the KUENM, the records of the species in native and invasive condition from the GBIF portal, and records obtained through field trips and bioclimatic variables from Worldclim2 were used. Changes in potential distribution were analyzed with the Biomod2. A total of 1072 occurrence records were found for U. europaeus and 109 records were found in Colombia in the Cordillera Central and Oriental, where an expansion of the altitudinal range was evidenced from 2000 to 4052 m above sea level. Climate change models for Colombia showed that the creation of new areas for potential establishment is less than 1% and there is a reduction in potential distribution of 12 and 31% due to unsuitable climatic conditions that would affect their germination capacity. However, given its potential for adaptation, the invasions will persist in the new conditions and will continue their colonization process at higher altitudes where they find optimal temperatures for their germination and establishment.
Sustainable and modern bio-based technologies: new approachs to food safety and security
Authors: Demirel Özge , Güneş Hasret , Can Canan 
Published: April 2024

AbstractTwo major challenges in the modern world are ensuring food security and using sustainability in limited areas, in the face of climate change and population growth. It is aimed to raise awareness on the importance of working from a multidisciplinary perspective, together with developing technology and science, in solving current problems/troubles, and that the simultaneous use of modern bio-based technologies with innovative techniques will ensure an effective role in overcoming many difficulties that future generations will face, as well as sustainability can be achieved. The review provides a detailed systematic review and analysis of the mutually supportive use of modern bio-based technologies and sustainable agricultural system technologies within the framework of this subject. The review, in which universally reliable databases were used, was carried out using information obtained from practice and approach-based articles (> 4000). The fact that the main topic has the lowest publication content in terms of "sustainability and biotechnology" according to the analysis carried out within the determined keywords indicates the need for additional research and applications and to contribute to the literature. Similar to review aim, it has also been concluded that the development of a multidisciplinary, interdisciplinary and transdisciplinary perspective that provides a comprehensive and broader focus on eliminating the deficiencies in the fields will play a major role in solving problems related to the sustainability of food safety and security. Thus, contributing to the protection of world food security should be considered as another important outcome that should not be forgotten. In short, being aware that the world, especially its resources, are not infinite and for the continuity of healthy generations, the sustainability of the world, food and agriculture, food safety and security must be meticulously protected, developed with innovative technologies and also carried a step forward by developing more effective strategies in this field of work, which is of great importance for life.
Validation of the Arabic Version of Feeding Handicap Index for Children with Developmental Disabilities (A-FHI-C)
Authors: Mahmoud Nesreen Fathi , Mohammed Zeinab , Mohammed Hassnaa Othman , Lotfy Alshimaa Mohsen Mohamed 
Published: April 2024

AbstractChildren with developmental disabilities have different feeding and swallowing problems. The purposes of the present study were to develop an Arabic version of the FHI-C and to evaluate its validity, consistency, and reliability in Arabic children with developmental disabilities for assessing how feeding and swallowing problems impair the physical, functional, and emotional aspects of children’s lives. A prospective study including 113 children [62 children with autism spectrum disorder (ASD), 24 with cerebral palsy (CP), 27 with intellectual disability (ID)], in the age range of 2 to 10 years, selected randomly from the swallowing clinic, phoniatrics unit, Otorhinolaryngology department, University hospital between September 2023 and December 2023 complaining of feeding and swallowing problems. Validity was established by comparing patients` scores to typically developed controls (31 children). For test–retest reliability, forty parents filled out the A-FHI-C again two weeks after their initial visit. Cronbach’s alpha for A-FHI-C was 0.986, indicating good internal consistency. Intraclass correlation showed 0.850 with a 95% confidence interval from 0.779 to 0.898. All three clinical groups had significantly higher total FHI-C and FHI-C domain scores than the control group, indicating good validation. A-FHI-C was found to have significantly high test–retest reliability. The current study indicates that in children with ASD, CP, ID, feeding problems are more prevalent than children who are typically developed. The scores obtained can be used by phoniatricans to evaluate feeding problems and monitor the progress of the therapy plan in children with developmental disorders.