bluuebunny/crossref_metadata_2025_split huggingface dataset:
The synthesis of nicotinic acid‐7‐13C
Authors: Meinert M. C. , Nunez H. A. , Syerrum R. U. 
Published: October 2006

AbstractNicotinic acid, an intermediate in the pyridine nucleotide cycle, was labeled with 13C at the 7 position. The reaction of CuCN‐13C (prepared from NaCN‐13C) with 3‐bromopyridine, followed by hydrolysis to the acid and purification by ion exchange chromatography, gave an overall yield of 72% nicotinic acid‐7‐13C. This greater than 3‐fold increase in yield over previous methods is the result of in situ hydrolysis of the nitrile intermediate.
A convenient synthesis of carboxyl‐labelled ricinoleic acid
Authors: McChesney James D. , Fraher Phil 
Published: October 2006

AbstractThe exchange reaction of carboxyl groups with labelled carbon dioxide has been utilized for the preparation of carboxyl labelled ricinoleic acid. The thermal instability of ricinoleic acid is overcome by pyrolysis of the t‐butyl ether‐t‐butyl ester in the presence of labelled carbonate. The developed procedure should be appropriate to other thermally unstable substrates.
Synthesis of 2‐fluorobenzo[rst]pentaphene and 2‐fluorobenzo[rst]pentaphene‐5‐13C
Authors: Sardella D. J. , Mariani H. A. , Mahathalang P. , Boger E. 
Published: October 2006

AbstractThe syntheses of 2‐fluorobenzo[rst]pentaphene and 2‐fluoro‐benzo[rst]pentaphene‐5‐ 13C (70% 13C) and their precursors are described, and relevant directly‐bonded 13C‐1H couplings reported.The labelled material was used to differentiate the NMR resonances of the 5‐ and 8‐protons, in connection with our studies of the remote effect exercised by fluorine on their reactivities toward electrophilic aromatic substitution, and on the carcinogenic activity of benzo[rst]pentaphene.
Syntheses d'Indoles Specifiquement Deuteries
Authors: Lautié Marie France 
Published: October 2006

AbstractDeuterated indoles were prepared either by exchange (indole ND, ‐1,3‐d2,‐3d,‐d7) or by suitable reactions on indole derivatives (indole ‐2d, ‐5,7‐d2 ‐4, 5, 6, 7 d4). These latter compounds can be deuterated by exchange on the 1 and 3 positions of the pyrrole moiety.
Rapid synthsls of14C LABELLED 4(5)‐amino‐5(4)‐imidazole‐carboxamide
Authors: Koltai E. , Bánfi D. , Szatmári I. , Hornyák‐Hámori Maria , Schawartz J. , Szüts T. 
Published: October 2006

Abstract4(5)‐Amino‐5(4)‐imidazole‐2‐14C‐carboxamide was prepared in a two step synthesis. K14CN was converted into ethyl formimidate‐14C hydrochloride, which was reacted with 2‐amino‐2‐amidino‐acetamide dihydrochloride to give the desired product.
Synthesis of ortho deuterated phenylisocyanate under mild conditions
Authors: Masson M. A. , Dormoy J. R. 
Published: October 2006

AbstractA new method has been developed for the synthesis of phenylisocyanate 2‐2H through the use of azido (tris dimethylamino) phosphonium hexafluorophosphate and benzoic acid 2‐2H. The product prepared is obtained with a high percentage of isotopic substitution, specificity of label and appreciable yield.
Synthesis of 3‐cyano‐4‐methyl‐5(14C)‐methyl‐2‐(5‐14C)pyrrolyloxamic acid
Authors: Honigberg I. L. , Meltzer N. M. , Blanton C. D. 
Published: October 2006

AbstractA synthesis of 3‐cyano‐4‐methyl‐5 (14C)‐methyl‐2‐(5‐14C)pyrrolyloxamic acid is described. The compound, having specific activity of 66.7 μCi/mmole, was obtained in 19.68% overall yield from uniformly labelled 14C‐L‐alanine.
A high yield synthesis of dimethylsulfide‐d6, and preparation of chloro‐(dimethylsulfide‐d6)gold(i) and trichloro(dimethylsulfide‐d6)gold(III)
Authors: Shaw C. Frank , Cancro Margaret P. , Butler Ian S. 
Published: October 2006

AbstractDimethylsulfide‐d6 has been prepared in higher yield than reported previously by an improved method involving the reduction of dimethylsulfoxide‐d6 with triphenylphosphine in a solvent mixture of carbon tetrachloride and 2,2‐dimethoxydiethyl ether at 0°C. The high isotopic purity of the compound was demonstrated by its gas phase infrared and mass spectra. Its utility as a ligand in coordination chemistry was then shown by the synthesis of two typical gold complexes, viz., chloro(dimethylsulfide‐d6)gold(I) and trichloro(dimethylsulfide‐d6)gold(III).
Radioactively labelled epoxides part II. (1) tritium labelled cyclohexene oxide, transstilbene oxide and phenanthrene 9,10‐oxide
Authors: Oesch Franz , Sparrow Alan J. , Platt Karl L. 
Published: October 2006

AbstractTritium labelled cyclohexene oxide, trans‐stilbene oxide and phenanthrene 9,10‐oxide were prepared with specific activities of 0.7 ‐ 1.1 mCi per mmole starting with monoor diketo compounds.Tritium was introduced by reducing the ketone precursors with tritiated complex metal hydrides.The resulting alcohols were transformed to the epoxides by methods described for the unlabelled compounds.The syntheses require only two or three steps and yield cyclohexene oxide, trans‐stilbene oxide and phenanthrene 9,10‐oxide, important substrates for the study of epoxide hydratase and glutathione S‐transferases in high radiochemical purity.
Aminozucker‐Derivate des Ferrocens und Ruthenocens ‐ Synthese und Markierung mit 14C und 103Ru
Authors: Schneider Michael , Wenzel Martin 
Published: October 2006

AbstractGlucosamine, galactosamine and mannosamine react with ferrocene‐ or ruthenocene‐carbaldehyde, respectively to yield the corresponding Schiff's bases, which are reduced at the CN‐bond and at the aldehyde function of the sugar moity. With 14C‐labelled amino‐sugars or 103Ru‐labelled ruthenocene‐carbaldehyde the labelled aminohexite compounds of the metallocenes are synthesized.
The synthesis of SQ‐14225‐14C [N‐[(S)‐2‐methyl‐3‐mercaptopropanoyl‐1‐14C]‐L‐proline]
Authors: Hasegawa M. , Ohyabu S. , Ueda T. , Yamaguchi M. 
Published: October 2006

AbstractThe preparation of SQ‐14225‐14C, anti‐hypertensive drug, is described. The starting material, methacrylic acid‐1‐14C, was prepared in a high yield by carbonation of the corresponding Grignard reagent with 14CO2. The final product was obtained from the acid through a four step synthesis with specific activity of 3.20 mCi/mmol. The overall radiochemical yield was 8.0% based on Ba14CO3.
Synthesis of tritium labelled verrucarol and verrucarin a
Authors: Yagen Boris , Jarvis Bruce B. 
Published: October 2006

AbstractTwo tritium labelled trichothecenes, verrucarol (2) and verrucarin A (5) were synthesized with high specific activity. Oxidation of verrucarol (1) to the 15‐dehydroverrucarol (3) followed by sodium borotritide reduction yielded [15‐3H]‐verrucarol (2). Reduction of 16‐mesyloxyverrucarin A (7) in a special buffer‐organic solvent system with a phase transfer catalyst, produced [16‐3H]‐verrucarin A (5). Final purification of the radioactive products was achieved by preparative thin layer chromatography. Their structures were assigned based on the analytical data of the corresponding nonradiolabelled compounds obtained from the nonradioactive preparations.
Synthesis of 4‐13C‐4‐hydroperoxycyclophosphamide and alpha‐13C‐4‐hydroperoxycyclophosphamide
Authors: Ho Chorng‐Kei , Ludeman Susan M. 
Published: October 2006

AbstractNew synthetic routes were developed for incorporating 13C into the oxazaphosphorine ring and nitrogen mustard functionality of cyclophosphamide metabolites. 1,2‐13C2‐Vinylbromide and ethylene oxide were used to synthesize 3,4‐13C2‐3‐butenyl N,N‐bis(2‐chloroethyl)phosphorodiamidate via the intermediacy of 3,4‐13C2‐3‐buten‐1‐ol. Ozonolysis of the phosphorodiamidate gave 4‐13C‐4‐hydroperoxycyclophosphamide with an overall yield of 16% which was 27‐times higher than a previously reported synthesis. As an extension of this synthetic pathway, 2‐13C‐ethyl bromoacetate was used to incorporate 13C into the C1 position of bis(2‐chloroethyl)amine hydrochloride which was used as a precursor to alpha‐13C‐4‐hydroperoxycyclophosphamide (obtained in 16% overall yield). Also discussed are applications of these pathways to the synthesis of diversely labelled (14C, 13C, 2H) 4‐hydroperoxycyclophosphamides, chirally‐labelled oxazaphosphorines, phosphoramide mustards, and related alkylating agents.
Synthesis of 13C‐ and 14C‐labeled ellagic acid
Authors: Mishra Nrusingha C. , Gold Barry 
Published: October 2006

AbstractThe syntheses of [13C]‐ and [14C]ellagic acid (EA) were accomplished by reacting [13C]‐ or [14C]CO2 with metalated 3,4,5‐trimethoxybenzene to afford trimethylgallic acid which was O‐demethylated with hydroiodic acid. Oxidation of the resulting labeled gallic acid with potassium persulfate produced EA. The yields of trimethylgallic acid and EA based on [14C]BaCO3 are 48 and 1%, respectively. Final purification of EA involved the use of preparative reversed‐phase HPLC and removal of the eluent buffer salts on a C18 Sep‐Pak column. The isotopic purity of [13C]EA was determined by 13C NMR. The [14C]EA had 99% radiochemical purity as determined by analytical HPLC and a specific activity of ca. 110 mCi/mmol.
Deuterierte herz‐affine technetium‐isonitril‐komplexe
Authors: Wenzel M. 
Published: October 2006

Abstractt ‐ Butylisonitril (TBI) and Methoxy‐isobutyl‐isonitril (MIBI) were labelled with deuterium leading to TBI‐d2 and MIBI‐d2 or MIBI‐d5. After labelling with 99mTc the organ‐distribution in mice and rats was studied. The deuterated isonitriles showed only a small increase in myocard‐affinity but a significant decrease in blood concentration, so more favourable ratios heart/blood were reached.
New synthesis system of (C‐11)propyl ketene and its reactons with various alcohols
Authors: Fujii Ryou , Imahori Yoshio , Ido Tatsuo , Yagyu Takehiko , Horii Hitoshi , Wakita Kazuo , Moriyama Yoshihiko , Ueda Satoshi , Yamamoto Y. Lucas , Nakahashi Hisamitsu 
Published: October 2006

AbstractA new synthesis of (C‐11)propyl ketene using a HCl/Helium gas mixture and glass beads was developed. This improved synthesis method gave high yields and good reproducibility, which had been difficult to attain with our previous method. The (C‐11) propyl ketene is a useful precursor for labeling, in high specific activity, bioactive compounds which have a hydroxyl group. The reactivity of (C‐11) propyl ketene in the acylation of various alcohols was evaluated. The relative reactivity of primary, secondary and tertiary alcohols were 1, 0.4 and 0.1, respectively, and the reactivity of the noncarrier added conditions was similar to that using cold propyl ketene. This (C‐11)propyl ketene was also useful for the formation of N‐butyl compounds, making it possible to label many bioactive compounds.
Synthesis of [1,3,5‐13C3]benzoic acid and [2,4,6,7‐13C4]benzoic acid from 13C‐labelled sodium pyruvates
Authors: Akira Kazuki , Baba Shigeo 
Published: October 2006

AbstractThe synthesis of [1,3,5‐13C3]‐ and [2,4,6,7‐13C4]benzoic acid (5a and 5b) from [2‐13C]‐ and [3‐13C]sodium pyruvate (1a and 1b), for in vitro and in vivo tracer studies using 13C nuclear magnetic resonance (NMR) spectroscopy, is reported. After condensation of 1 to [13C]methyldihydrotrimesic acids 2 using sodium hydroxide, decarboxylation to [13C]uvitic acid 3 was carried out using conc. sulfuric acid. Additional decarboxylation of 3 was achieved with cupric oxide and quinoline, and the resulting [13C]toluenes 4 were effectively trapped, using a simplified decarboxylation apparatus. Compounds 4 were subsequently oxidized to 5 using potassium permanganate without further purification. The overall yields of 5 from 1 were 26–28 %, with isotopic purities of 96–98 %. In addition, the assignments for 13C NMR signals of benzoic acid were first substantiated.
Synthesis of SCH 42427 labelled with 14C in two different positions
Authors: Hesk D. , Bowlen C. , Duelfer T. , Koharski D. , McNamara P. , Saluja S. 
Published: October 2006

Abstract[14C]‐Sch 42427 was synthesized by two different methods, resulting in incorporation of the label in different parts of the molecule. In the first synthesis [benzyl‐α‐14C]‐Sch 42427 was synthesized in overall 1.7% yield via a 6 step procedure, using [14C]‐trimethyl sulphoxonium iodide as the source of label. The second synthesis gave rise to [SO2‐14CH3]‐Sch 42427, which was prepared via a 2 step procedure from [14C]‐sodium thiomethoxide. Radiochemical purities were greater than 99% for both batches, and analysis by chiral hplc failed to detect any of the undesired S,S enantiomer.
Synthesis of unlabelled and tritium labelled 4‐isothiocyanato‐1‐(1‐phenylcyclohexyl)piperidine (fourphit), tools for the study of the dopamine reuptake complex.
Authors: Linders Joannes T. M. , de Costa Brian R. , Grayson Neile A. , Rice Kenner C. 
Published: October 2006

AbstractThe synthesis of high specific activity tritium labelled 4‐isothiocyanato‐1‐(1‐phenylcyclohexyl)piperidine ([3H]fourphit), a probe for the autoradiographic study of the dopamine reuptake complex, is described. An improved, facile synthesis of unlabelled fourphit in high overall yield is also presented. Detailed study of the interaction of unlabelled and tritium labelled fourphit with the dopamine reuptake complex may lead to a better understanding of the actions of cocaine.
Practical synthesis of 14C S‐ribosyl‐l‐homocysteine uniformely labelled on the sugar moiety. An enzymatic route from (U‐14C) adenosine
Authors: Guillerm G. , Allart B. 
Published: October 2006

Abstract[(U‐14C) S‐Ribosyl]‐L‐homocysteine has been prepared enzymatically from (U‐14C) adenosine in two steps using S‐adenosyl homocysteine hydrolase (EC.3.31.1) and bacterial S‐adenosyl homocysteine nucleosidase (EC.3.2.2.9) as catalysts.
Synthesis of tritium labelled 24‐epibrassinolide
Authors: Kolbe A. , Marquardt V. , Adam G. 
Published: October 2006

AbstractDeuterium and tritium 5,7,7‐tris‐labelled 24‐epibrassinolide were prepared by base catalyzed exchange reaction using 24‐epicastasterone tetraacetate 1 or bis‐isopropylidenedioxy‐24‐epicastasterone 8 and labelled water. Baeyer‐Villiger oxidation of the obtained labelled 6‐ketones 2 and 3 with CF3CO3H gave after alkaline deacetylation of the resulting 4 and 5 the desired tris‐labelled 24‐epibrassinolides 6 and 7, respectively, or starting from 9 under simultaneous oxidation and deprotection in one step the same final products.
Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol
Authors: Ackland M. J. , Howard M. R. , Jacobsen E. J. , Secreast S. L. , Dring L. G. 
Published: October 2006

AbstractThis paper describes the synthesis and characterisation of 2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]‐[14C]‐ methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol and 2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐[13C2]‐pyrimidinyl)‐1‐ piperazinyl]‐[13C]‐methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐ benzopyran‐6‐ol. Intermediates in the synthesis included R‐(+)‐[13C]‐Trolox®(R‐(+)‐6‐hydroxy‐2,5,7,8‐tetramethylchroman‐[2‐13C]‐carboxylic acid), [2,5‐13C2]‐barbituric acid, 2,4,6‐trichloro‐[2,5‐13C2]‐pyrimidine, 2,6‐di‐pyrrolidinyl‐4‐chloro‐[2,5‐13C2]‐pyrimidine and 4‐(1‐piperazinyl)‐2,6‐di‐1‐pyrrolidinyl‐[2,5‐13C2]‐ pyrimidine.
Synthesis of carrier‐free rhenium‐188(V)DMSA using triphenyl phosphine as a facile reducing agent
Authors: Lisic Edward C. , Mirzadeh Saed , Knapp F. F. 
Published: October 2006

AbstractRhenium‐188‐labeled ReOCl3(PPh3)2 is an important reactive complex which can be prepared in > 95% yield by the reaction of perrhenate (188ReO4−) or perrhenic acid with triphenyl phosphine (PPh3) and HCl with subsequent extraction into CH2Cl2 or CHCl3. The yield is dependent upon a high HCl concentration. Because of the potential important use of 188Re(V)DMSA for therapy of tumors of the head and neck, we have used the 188ReOCl3(PPh3)intermediate for the facile synthesis of the ReO(DMSA)2 complex.Although the Re(V)O(DMSA)2 is a monovalent anion, for simplicity the charge is not included and the species denoted as Re(V)DMSA in this discussion
Reaction of ReOCl3(PPh3)2 with naturally abundant Re or carrier free Re‐188, with DMSA (meso‐1,2‐dimercaptosuccinic acid) yields ReO(DMSA)2 in high yield. The 188Re(V)DMSA can also be prepared by reaction of Re‐188 perrhenate or perrhenic acid with SnCl2 in the presence of DMSA.
Synthesis of tritium labeled (±) 15‐deoxyspergualin trihydrochloride
Authors: Dischino D. D. , Cook D. J. , Saulnier M. G. , Tepper M. A. 
Published: October 2006

AbstractTritium labeled (±) 15‐deoxyspergualin, (±)‐7‐[(aminoiminomethyl) amino]‐N‐[2‐[[4‐[(3‐aminopropyl) amino]butyl]amino]‐1‐hydroxy‐2‐oxoethyl][4,5‐3H2]heptanamide trihydrochloride was prepared from the acid catalyzed condensation of 7‐guanidino[4,5‐3H2] heptanamide hydrochloride and glyoxyloylspermidine dihydrochloride in a total yield of 14.5%. The radiochemical purity was determined to be 91.1% and 95.4% on two different HPLC systems.
Tritium studies of catalysis over microporous aluminophosphate surfaces
Authors: Long Mervyn A. , He Simon J. X. , Than Chit 
Published: October 2006

AbstractMicroporous AlPO4‐5 catalysts exhibit catalytic activity for tritium isotope exchange and other reactions but the activity of the catalyst may vary widely from one batch of catalyst to another although all catalyst samples appear to show pure AlPO4‐5 phase. This catalytic activity appears to correlate with the presence of octahedral aluminium in the catalyst samples as revealed by solid sate 27Al NMR spectroscopy and this is attributed to defect sites in the lattice. The exchange patterns may show high regional specificity. These patterns have some of the features of acid catalysis but are assumed to be modified by the constraints imposed by the micropore geometry.
Tritium NMR in the analysis of tritiated compounds
Authors: Kaspersen Frans M. , Funke Carel W. , Vader Jan , Wagenaars Gerard N. 
Published: October 2006

AbstractAn overview is given of the possibilites of 3H NMR in the characterisation of 3H‐labelled compounds. This technique gives information on the identity of the tritiated compounds, the position of the tritium, the distribution of the label and even the radiochemical purity of the labelled products.
Enzymatic and chemical labelling of prostaglandin E1 and 13,14‐dihydro‐15‐keto‐prostaglandin E1
Authors: Tsikas Dimitrios , Bracht Stefan , Stichtenoth Dirk , Frölich Jürgen C. 
Published: October 2006

AbstractChemical and enzymatic tools were employed to synthesize [1,1‐18O2]‐prostaglandin (PG) E1, [1,1‐18O2]‐13,14‐dihydro‐15‐keto‐PGE1 and [5,6‐3H2]‐13,14‐dihydro‐15‐keto‐PGE1 starting from the corresponding unlabelled compounds adn [5,6‐3H2]‐PGE1, respectively. Reaction products were purified by high‐performance liquid chromatography and their isotopic purity was determined by gas chromatographymass spectrometry (GC‐MS). The utility of [1,1‐18O2]‐PGE1 and [1,1‐18O2]‐13,14‐dihydro‐15‐keto‐PGE1 as internal standards for GC‐MS analysis of the corresponding endogenous compounds in biological fluids is demonstrated. [5,6‐3H2]‐13,14‐dihydro‐15‐keto‐PGE1 was found to be useful in developing extraction and purification procedures for the quantitation of endogenous 13,14‐dihydro‐15‐keto‐PGE1 in human plasma by GC‐tandem MS.
Synthesis of 14C‐labelled aminoguanidine
Authors: Lo Theodore W. C. , Thornalley Paul J. 
Published: October 2006

Abstract[14C]Aminoguanidine was synthesized by the reaction of hydrazine sulphate with barium [14C]cyanamide in a one‐step synthesis, and conveniently isolated by crystallization as the bicarbonate salt. The yield was 32%.
Synthesis of 15N labelled isophosphoramide mustard
Authors: Shulman‐Roskes Ellen M. , Gamcsik Michael P. , Colvin O. Michael , Chang Young H. , Koo Kyo I. , Ludeman Susan M. 
Published: October 2006

AbstractThe ifosfamide metabolite isophosphoramide mustard (IPM) was synthesized with isotopic enrichment at each nitrogen site. Glycine‐15N was converted to 2‐chloroethylamine‐15N hydrochloride (4 steps, 21% net yield) which was then reacted with phenyl dichlorophosphate to provide N,N′‐bis(2‐chloroethyl)phosphorodiamidic‐15N2 acid phenyl ester [62%, PhOP(O) (15NHCH2CH2Cl)2]. Catalytic hydrogenation of this phenyl ester followed by the addition of cyclohexylamine (CHA) provided IPM‐15N2 as the CHA salt (63%).
Acid‐catalyzed deuterium exchange of aromatic protons. Part III1: Accelerated exchange by microwave irradiation
Authors: Köves G. J. 
Published: October 2006

AbstractConventional acid‐catalyzed 2H/1H exchange in aromatic rings requires long reaction times, high temperatures and pressure. This paper reports that accelerated deuterium exchange can be achieved in a microwave oven. Experiments were carried out on benzodiazepines, tricyclic antidepressants and phenothiazines. The reaction time was decreased from days to minutes, the preparatory work was simpler than with conventional heating and the labelled products were cleaner.
Synthesis of [4,5‐3H‐Leu4]Salmon Calcitonin
Authors: Birtle T. , White A. J. , Woodhouse D. P. 
Published: October 2006

AbstractThe synthesis of salmon calcitonin, a C‐terminal amide dotriacontapeptide, labelled with tritium in the leucine residue at position 4 to a specific activity of 100Ci mmole−1 is described. The peptide was assembled using the Fmoc‐Polyamide solid‐phase synthesis strategy incorporating tritium labelled leucine, in the form of Fmoc‐4,5‐3H‐leucinepentafluorophenylester, at the appropriate stage. The Fmoc‐4,5‐3H‐leucinepentafluorophenylester was prepared via a multistage synthesis from 4,5‐dehydroleucine.
Biotechnological production of high specific activity L‐35 S‐cysteine and L‐35 S‐methionine by using a diploid yeast Saccharomyces cerevisiae
Authors: Gajendiran N. , Jayachandran N. , Rao B. S. , Unny V. K. P. , Thyagarajan S. 
Published: October 2006

AbstractHigh specific activity L‐35 S‐cysteine and L‐35 S‐methionine were synthesised by using a wild type diploid strain of baker's yeast—Saccharomyces cerevisiae. Yeast cells were grown in a sulphur depleted synthetic medium in which Na2 35 SO4 (50 mCi/ml) was supplemented as the sole sulphur source. The level of incorporation was 60% on an average. The protein hydrolysate of the cultured cells was subjected to paper and column chromatographic separations to get the individual L‐35 S‐aminoacids. The radiochemical yields of cysteine and methionine were 6–7% and 18–20% respectively. The radiochemical purity of the products was >95%. The highest specific activity for the products obtained by employing this method was 1100 Ci/mmole from the starting material, Na2 35 SO4, with a specific activity of 1350 Ci/mmole.
Synthesis of [D5‐ethyl]‐tamoxifen; a mechanistic probe of tamoxifen induced hepatic DNA adduct formation
Authors: Horton Martin N. , Jarman Michael , Potter Gerard A. 
Published: October 2006

AbstractTamoxifen which incorporates a fully deuterated ethyl group, [D5‐ethyl]‐tamoxifen, has been synthesised in order to probe the mechanism of tamoxifen induced hepatic DNA adduct formation. The pentadeuteroethyl group was introduced into the tamoxifen structure by treatment of the ketone precursor 1‐[4‐(2‐chloroethoxy)phenyl]‐2‐phenylethanone, as its sodium enolate, with [D5]‐iodoethane.
The synthesis of d6‐α‐farnesene
Authors: Fielder Simon , Rowan Daryl D. 
Published: October 2006

AbstractD6‐α‐Farnesene (3,7‐dimethyl‐11‐2H3‐methyl‐12,12,12‐2H3‐dodeca‐1,3E,6E,10‐tetraene) has been synthesised by two routes. Thermolysis of 2‐geranyl‐3‐methylsulpholene (5) yielded unlabelled α‐farnesene (93%) which was epoxidized at Δ10 in 31% yield. Oxidative cleavage of the epoxide (42%) and Wittig elaboration of the resultant trienal with d6‐isopropyl triphenylphosphorane gave d6‐α‐farnesene (73%). Alternatively, selective epoxidation of (5) gave the terminal 6′,7′ mono‐epoxide in 74% yield. Oxidative cleavage (73%) and Wittig elaboration of the resultant aldehyde yielded deuterated 2‐geranyl‐3‐methylsulpholene (46%). Thermal elimination of sulphur dioxide afforded the title compound in 91% yield.