bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Two-Season Impact Study of Satellite and In Situ Data in the NCEP Global Data Assimilation System
Authors: Zapotocny Tom H. , Jung James A. , Le Marshall John F. , Treadon Russ E. 
Published: August 2007

Abstract
Observing system experiments are used to quantify the contributions to the forecast made by conventional in situ and remotely sensed satellite data. The impact of each data type is assessed by comparing the analyses and forecasts based on an observing system using all data types. The analysis and forecast model used for these observing system experiments is the National Centers for Environmental Prediction (NCEP) Global Data Assimilation/Forecast System (GDAS/GFS). The case studies chosen consist of 45-day periods during January–February 2003 and August–September 2003. During these periods, a T254–64 layer version of NCEP’s Global Spectral Model was used. The control run utilizes NCEP’s operational database and consists of all data types routinely assimilated in the GDAS. The two experimental runs have either all the conventional in situ data denied (NoCon) or all the remotely sensed satellite data denied (NoSat). Differences between the control and experimental runs are accumulated over the 45-day periods and analyzed to demonstrate the forecast impact of these data types through 168 h. Anomaly correlations, forecast impacts, and hurricane track forecasts are evaluated for both experiments. Anomaly correlations of geopotential height are evaluated over the polar caps and midlatitudes of both the Northern and Southern Hemispheres for spectral waves 1–20. Forecast impacts related to conventional meteorological parameters are evaluated. The parameters examined include geopotential height, precipitable water, temperature, the u component of the wind, wind vector differences, and relative humidity. Comparisons are made on multiple pressure levels extending from 10 to 1000 hPa. Hurricane track forecasts are evaluated during August and September for both the Atlantic and eastern Pacific basins. The results demonstrate a positive forecast impact from both the conventional in situ and remotely sensed satellite data during both seasons in both hemispheres. The positive forecast impacts from the conventional and satellite data are of similar magnitude in the Northern Hemisphere; however, the contribution to forecast quality from satellite data is considerably larger than the conventional data in the Southern Hemisphere. The importance of satellite data also generally increases at longer forecast times relative to conventional data. Finally, the accuracy of hurricane track forecasts benefits from the inclusion of both conventional and satellite data.
A Proposal Concerning the Physical Rate of Dissipation of Materials with Memory: The Non-isothermal Case
Authors: Golden J.M. 
Published: August 2007

It has been known for several decades that the free energy and entropy of a material with memory is not in general uniquely determined, nor is the rate of dissipation. The objective of the present work is to propose a formula for the physical free energy and rate of dissipation of a material with memory, described by a constitutive equation with linear memory terms and non-linear equilibrium contributions, under non-isothermal conditions. This is a generalization of work recently presented for the linear scalar case. This formula follows from a new physical hypothesis of Maximum Parametric Symmetry, which states that the physical free energy has the closest possible level of symmetry among the parameters of the theory to that of the work function. The final formula proposed can be expressed in simple, closed form. It is shown that non-trivial equivalence classes of states, in the sense of Noll, exist only if the material has a relaxation function derivative, the Fourier transform of which has only isolated singularities in the complex frequency plane. The members of the family of free energies used to determine the physical free energy are all functions of such an equivalence class.
Involvement of E-selectin in recruitment of endothelial progenitor cells and angiogenesis in ischemic muscle
Authors: Oh Il-Young , Yoon Chang-Hwan , Hur Jin , Kim Ji-Hyun , Kim Tae-Youn , Lee Choon-Soo , Park Kyung-Woo , Chae In-Ho , Oh Byung-Hee , Park Young-Bae , Kim Hyo-Soo 
Published: August 2007

AbstractE-selectin plays critical roles in tethering leukocytes to endothelial cells (ECs). We studied the role of E-selectin in endothelial progenitor cell (EPC) homing and vasculogenesis. After ischemia, the expression of E-selectin on ECs peaked 6 to 12 hours and returned to baseline at 24 hours, whereas the level of soluble E-selectin (sE-selectin) in serum increased over 24 hours and remained high at day 7. Mouse bone marrow–derived EPCs expressed not only E-selectin but also its ligand. Homing of circulating EPCs to ischemic limb was significantly impaired in E-selectin knock-out mice, as well as wild-type mice pretreated with blocking antibody against E-selectin, which was rescued by local sE-selectin injection. Mechanism for this is that sE-selectin stimulated not only ECs to express ICAM-1, but also EPCs to secrete interleukin-8 (IL-8), leading to enhanced migration and incorporation to ECs capillary formation. In therapeutic aspect, local treatment with sE-selectin enhanced efficacy of EPC transplantation for vasculogenesis and salvage of ischemic limb. Conversely, when E-selectin was knocked down by E-selectin small interfering RNA, blood flow recovery after EPC transplantation was significantly impaired. But this impaired vasculogenesis was rescued by sE-selectin. In conclusion, these data demonstrate E-selectin is a pivotal molecule for EPCs' homing to ischemic limb and vasculogenesis.
CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential
Authors: Deaglio Silvia , Vaisitti Tiziana , Aydin Semra , Bergui Luciana , D'Arena Giovanni , Bonello Lisa , Omedé Paola , Scatolini Maria , Jaksic Ozren , Chiorino Giovanna , Efremov Dimitar , Malavasi Fabio 
Published: August 2007

AbstractOur interest in chronic lymphocytic leukemia (CLL) derives primarily from the exploitation of human diseases as strategic models for defining the in vivo biological roles of CD38. Using this model, we showed that CD38 triggers robust proliferation/survival signals modulated through the interactions with the CD31 ligand expressed by nurselike cells and by the stromal/endothelial components. By analyzing a cohort of 56 patients with clinically and molecularly characterized CLL, we show that (1) patients with CD38+/ZAP-70+ are characterized by enhanced migration toward Stromal derived factor-1α (SDF-1α)/CXCL12; (2) CD38 ligation leads to tyrosine phosphorylation of ZAP-70, showing that these markers are functionally linked; (3) ZAP-70 represents a limiting factor for the CD38 pathway in the CLL context, as shown by studying CD38-mediated signal transduction in 26 molecularly characterized patients; and (4) the CLL subgroup of patients defined on the basis of migratory potential is marked by a specific genetic signature, with a significant number of differentially expressed genes being involved in cell-cell interactions and movement. Altogether, the results of this work provide biological evidence for why the combined analysis of CD38 and ZAP-70 expression as determined in several clinical trials results in more dependable identification of patients with CLL who have aggressive disease.
Unexpected presence of Fagus orientalis complex in Italy as inferred from 45,000-year-old DNA pollen samples from Venice lagoon
Authors: Paffetti Donatella , Vettori Cristina , Caramelli David , Vernesi Cristiano , Lari Martina , Paganelli Arturo , Paule Ladislav , Giannini Raffaello 
Published: August 2007

Abstract

Background
Phylogeographic analyses on the Western Euroasiatic Fagus taxa (F. orientalis, F. sylvatica, F. taurica and F. moesiaca) is available, however, the subdivision of Fagus spp. is unresolved and there is no consensus on the phylogeny and on the identification (both with morphological than molecular markers) of Fagus Eurasiatic taxa.
For the first time molecular analyses of ancient pollen, dated at least 45,000 years ago, were used in combination with the phylogeny analysis on current species, to identify the Fagus spp. present during the Last Interglacial period in Italy.
In this work we aim at testing if the trn L-trn F chloroplast DNA (cpDNA) region, that has been previously proved efficient in discriminating different Quercus taxa, can be employed in distinguishing the Fagus species and in identifying the ancient pollen.

Results
86 populations from 4 Western Euroasistic taxa were sampled, and sequenced for the trn L-trn F region to verify the efficiency of this cpDNA region in identifying the Fagus spp.. Furthermore, Fagus crenata (2 populations), Fagus grandifolia (2 populations), Fagus japonica, Fagus hayatae, Quercus species and Castanea species were analysed to better resolve the phylogenetic inference.
Our results show that this cpDNA region harbour some informative sites that allow to infer relationships among the species within the Fagaceae family. In particular, few specific and fixed mutations were able to discriminate and identify all the different Fagus species.
Considering a short fragment of 176 base pairs within the trn L intron, 2 transversions were found able in distinguishing the F. orientalis complex taxa (F. orientalis, F. taurica and F. moesiaca) from the remaining Fagus spp. (F. sylvatica, F. japonica, F. hayataea, F. crenata and F. grandifolia). This permits to analyse this fragment also in ancient samples, where DNA is usually highly degraded.
The sequences data indicate that the DNA recovered from ancient pollen belongs to the F. orientalis complex since it displays the informative sites characteristic of this complex.

Conclusion
The ancient DNA sequences demonstrate for the first time that, in contrast to current knowledge based on palynological and macrofossil data, the F. orientalis complex was already present during the Tyrrhenian period in what is now the Venice lagoon (Italy).
This is a new and important insight considering that nowadays West Europe is not the natural area of Fagus orientalis complex, and up to now nobody has hypothesized the presence during the Last Interglacial period of F. orientalis complex in Italy.
Direct cell-to-cell spread of a pathogenic yeast
Authors: Ma Hansong , Croudace Joanne E , Lammas David A , May Robin C 
Published: August 2007

Abstract

Background
Cryptococcosis, a fatal fungal infection of the central nervous system, is one of the major killers of AIDS patients and other immunocompromised hosts. The causative agent, Cryptococcus neoformans, has a remarkable ability to 'hide' and proliferate within phagocytic cells of the human immune system. This intracellular phase is thought to underlie the ability of the pathogen to remain latent for long periods of time within infected individuals.

Results
We now report that Cryptococcus is able to undergo 'lateral transfer' between phagocytes, moving directly from infected to uninfected macrophages. This novel process was observed in both C. neoformans serotypes (A and D) and occurs in both immortalised cell lines and in primary human macrophages. Lateral transfer is independent of the initial route of uptake, since both serum-opsonised and antibody-opsonised C. neoformans are able to undergo direct cell-to-cell transfer.

Conclusion
We provide the first evidence for lateral transfer of a human fungal pathogen. This rare event may occur repeatedly during latent cryptococcal infections, thereby allowing the pathogen to remain concealed from the immune system and protecting it from exposure to antifungal agents.
Glycosaminoglycan profiles of repair tissue formed following autologous chondrocyte implantation differ from control cartilage
Authors: Sharma Aarti , Wood Lindsay D , Richardson James B , Roberts Sally , Kuiper Nicola J 
Published: August 2007

AbstractCurrently, autologous chondrocyte implantation (ACI) is the most commonly used cell-based therapy for the treatment of isolated femoral condyle lesions of the knee. A small number of centres performing ACI have reported encouraging long-term clinical results, but there is currently a lack of quantitative and qualitative biochemical data regarding the nature of the repair tissue. Glycosaminoglycan (GAG) structure influences physiological function and is likely to be important in the long-term stability of the repair tissue. The objective of this study was to use fluorophore-assisted carbohydrate electrophoresis (FACE) to both quantitatively and qualitatively analyse the GAG composition of repair tissue biopsies and compare them with age-matched cadaveric controls. We used immunohistochemistry to provide a baseline reference for comparison. Biopsies were taken from eight patients (22 to 52 years old) 1 year after ACI treatment and from four cadavers (20 to 50 years old). FACE quantitatively profiled the GAGs in as little as 5 μg of cartilage. The pattern and intensity of immunostaining were generally comparable with the data obtained with FACE. In the ACI repair tissue, there was a twofold reduction in chondroitin sulphate and keratan sulphate compared with age-matched control cartilage. By contrast, there was an increase in hyaluronan with significantly shorter chondroitin sulphate chains and less chondroitin 6-sulphate in repair tissue than control cartilage. The composition of the repair tissue thus is not identical to mature articular cartilage.
BCoR-L1 variation and breast cancer
Authors: Lose Felicity , Arnold Jeremy , Young David B , Brown Carolyn J , Mann Graham J , Pupo Gulietta M ,   The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Khanna Kum Kum , Chenevix-Trench Georgia , Spurdle Amanda B 
Published: August 2007

Abstract
Introduction
BRCA1 is involved in numerous essential processes in the cell, and the effects of BRCA1 dysfunction in breast cancer carcinogenesis are well described. Many of the breast cancer susceptibility genes such as BRCA2, p53, ATM, CHEK2, and BRIP1 encode proteins that interact with BRCA1. BCL6 corepressor-like 1 (BCoR-L1) is a newly described BRCA1-interacting protein that displays high homology to several proteins known to be involved in the fundamental processes of DNA damage repair and transcription regulation. BCoR-L1 has been shown to play a role in transcription corepression, and expression of the X-linked BCoR-L1 gene has been reported to be dysregulated in breast cancer subjects. BCoR-L1 is located on the X chromosome and is subject to X inactivation.

Methods
We performed mutation analysis of 38 BRCA1/2 mutation-negative breast cancer families with male breast cancer, prostate cancer, and/or haplotype sharing around BCoR-L1 to determine whether there is a role for BCoR-L1 as a high-risk breast cancer predisposition gene. In addition, we conducted quantitative real-time PCR (qRT-PCR) on lymphoblastoid cell lines (LCLs) from the index cases from these families and a number of cancer cell lines to assess the role of BCoR-L1 dysregulation in cancer and cancer families.

Results
Very little variation was detected in the coding region, and qRT-PCR analysis revealed that BCoR-L1 expression is highly variable in cancer-free subjects, high-risk breast cancer patients, and cancer cell lines. We also report the investigation of a new expression control, DIDO1 (death inducer-obliterator 1), that is superior to GAPDH (glyceraldehyde-3-phosphate dehydrogenase) and UBC (ubiquitin C) for analysis of expression in LCLs.

Conclusion
Our results suggest that BCoR-L1 expression does not play a large role in predisposition to familial breast cancer.
Ozone laminae inside the Antarctic vortex produced by poleward filaments
Authors: Moustaoui M. , Teitelbaum H. , Valero F. P. J. 
Published: August 2007

AbstractOzone soundings made inside the Antarctic ozone hole exhibit localized ozone increases within thin layers in the lower stratosphere. These structures, called laminae, are explained as poleward filaments emerging from the vortex edge and transporting relatively ozone‐rich air into levels above the geographical site where the sounding equipment has been launched. It is shown that the interior of the Antarctic vortex is not completely isolated with respect to the poleward air mixing. Filament development follows the occurrence of inward breaking near the vortex edge in a region where isentropes are locally uplifted. It is shown that the circulation associated with such uplift may produce the poleward breaking. The role of that circulation is supported by simple barotropic simulations where development of a poleward filament is reproduced in a realistic circular undisturbed vortex. Copyright © 2003 Royal Meteorological Society
Student Involvement and Institutional Commitment to Diversity as Predictors of Native American Student Learning
Authors: Lundberg Carol A 
Published: August 2007

Using a national sample (n = 643) of Native American students who took the College Student Experiences Questionnaire (CSEQ), the researcher identified how student involvement and institutional commitment to diversity predicted student learning. Native American students reported higher levels of learning when the institution's commitment to diversity was strong and when students were frequently engaged in discussion with others, particularly when that discussion required students to synthesize and integrate information from various sources. Suggestions are made for student affairs efforts to boost institutional emphasis on diversity and to increase frequency of peer discussion.
DVD Reviews
Authors: Bould Mark , Evers Pamela S , Kreul James 
Published: August 2007

Sweet Sweetback's Baadasssss Song (1971)
Baadasssss! (aka How To Get the Man's Foot Outta Your Ass) (2003)
Personal angst as driving force
Divan (2003)
Prom Night in Kansas City (2002)
Film ist. [112] DVD Edition (2004)
Films from a Dark Room (2004)
Plastid division in an evolutionary context
Authors: Tveitaskog Astrid E. , Maple Jodi , Møller Simon G. 
Published: August 2007

Abstract
Plastids are derived from free-living cyanobacteria that were engulfed by eukaryotic host cells through the process of endosymbiosis and, like their cyanobacterial ancestors, divide by binary fission. Over the last decade the continued identification and functional analysis of plastid division components, coupled with ever-increasing genomic resources, have yielded insights into the origins and evolution of the plastid division mechanism in higher plants. Here we review the current understanding of the evolution of the chloroplast division proteins and present a model of how the machinery has developed to execute plastid division in Arabidopsis.
Variability of the mitochondrial genome in mammals at the inter-species/intra-species boundary
Authors: Santamaria Monica , Lanave Cecilia , Vicario Saverio , Saccone Cecilia 
Published: August 2007

Abstract
Genomic variations represent the molecular basis of the biodiversity of living organisms on which selection operates to generate evolution. In eukaryotes, genomic variability can be experienced in both nuclear and organellar, i.e. mitochondrial and plastid (where present), genomes, which can follow completely different evolution pathways, as revealed by comparative genomics analyses. In Metazoa, for which a substantial number of complete genome sequences are available (nuclear, but mainly mitochondrial), we are just starting to grasp the selective pressures operating on some basic features of the genome as a whole. In this brief review, we discuss the variability of the mitochondrial metazoan genome, with particular reference to mitochondrial DNA in mammals. In light of the recent assumption that a small segment of mitochondrial DNA may be used, particularly in Metazoa, as a species marker, some data on mitochondrial gene variability at the inter-species/intra-species boundary are reported. Intra-species variability has been evaluated in four mammalian species, Homo sapiens, Bos taurus, Sus scrofa and Canis familiaris, whereas the relationship between intra- and inter-species variability has been investigated in Bos taurus and Bos indicus.
‘Everyday language’ in emigrant letters and its implications for language historiography – the German case
Authors: Elspaß Stephan 
Published: August 2007

AbstractThe mass literacy drives of the 19thcentury have proved to be a landmark in German language history, as for the first time the majority of the people in the German-speaking countries were able to participate in the culture of writing. The full impact of the spread of writing among the lower social classes on language variation and change has, however, not yet been recognised in language historiography. With examples from grammar and spelling in private emigrant letters, the present article strongly argues for an alternative approach to language historiography, using such texts as a starting-point for a ‘language history from below’.
Writing and ‘the Standard’: England, 1795–1834
Authors: Fairman Tony 
Published: August 2007

Abstract
This article gives a detailed description and discussion of seven applications for poor relief, as found in the archives of English County Record Offices. All letters were written by or for poor writers between 1795 and 1834. As the variety used in these letters is not ‘Standard’, nor ‘dialect’, the second part of the article is devoted to the question of how this variety relates (or does not) to traditional linguistic views on standardisation. Contrary to the prevailing ‘standard language ideology’, it will be claimed that the present letters can only be interpreted adequately through a linguistic theory ‘which treats all varieties of English equally and discards none’.
… in writing the history of powerless people, drawing on conventional, published sources is far from enough.
Adam Hochschild (2002: 104)
Double diglossia – lower class writing in 19th-century Finland
Authors: Nordlund Taru 
Published: August 2007

AbstractThis paper analyses a number of typical features of lower-class writing in 19th-century Finland. The data consists of business letters written by local traders and farmers. These letters are compared to letters by Forest Finns, a group of early Finnish migrants to Scandinavia. The business letters are marked by three distinct influences: the older literary tradition, local dialects and the ‘rising literary genres’ of the 19thcentury. On the basis of the morpho-phonological level of the corpus texts, it will be argued that the lower-class writers intended to write a standard language, not a dialect.
From One‐ to Three‐Dimensional Organic Semiconductors: In Search of the Organic Silicon?
Authors: Roncali J. , Leriche P. , Cravino A. 
Published: August 2007

AbstractOrganic semiconductors based on π‐conjugated systems are the focus of considerable interest in the emerging area of soft or flexible photonics and electronics. Whereas in recent years the performances of devices such as organic light‐emitting diodes (OLEDs), organic field‐effect transistors (OFETs), or solar cells have undergone considerable progress, a number of technical and fundamental problems related to the low dimensionality of organic semiconductors based on linear π‐conjugated systems remain unsatisfactorily resolved. This low dimensionality results in an anisotropy of the optical and charge‐transport properties, which in turn implies a control of the material organization/molecular orientation during or after device fabrication. Such a constraint evidently represents a problem when device fabrication by solution‐based processes, such as printing techniques, is envisioned. The aim of this short Review is to illustrate possible alternative strategies based on the development of organic semiconductors with higher dimensionality, capable to exhibit isotropic electronic properties.