bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addition of lime juice and NaCl to minced seafood may stimulate the expression of Listeria monocytogenes virulence, adhesion, and stress response genes
Authors: Hosseini Hedayat , Abdollahzadeh Esmail , Pilevar Zahra 
Published: February 2024

AbstractListeria monocytogenes is a ubiquitous opportunistic bacterium responsible for deadly listeriosis outbreaks. This pathogen has been recognized as a significant food‐borne pathogen in seafood products. The present study aimed to investigate the transcript levels of virulence, adhesion, and stress response genes of L. monocytogenes upon exposure to sublethal levels of lime juice and NaCl in shrimp matrix. For this purpose, minced and broth shrimp samples (control, 2% NaCl, 5% NaCl, 25 μL/mL lime, and 50 μL/mL lime, as well as 2% NaCl+25 μL/mL lime) were inoculated with approximately 107 CFU/g or ml of L. monocytogenes, and subsequently, the samples were stored at 12°C or 37°C. For the minced samples, the transcription of one stress‐related (sigB), two adhesion (imo1634 and imo1847), and four virulence (hly, prf, intA, and plc) genes was assessed by RT‐qPCR after different storage times (0 and 48 h). Results showed that the transcript levels of sigB, imo1847, and imo1634 genes increased with increasing storage temperatures of shrimp broth (12°C to 37°C). At the beginning, the transcription of the studied genes decreased in all treatments of minced shrimp; however, after 48 h of storage at 12°C, the transcript levels of hly, prf, imo1847, imo1634, and intA genes were significantly upregulated up to 0.5–9 log2 fold‐change in all treatments compared to the control group (p < .05). These results highlight that the survived L. monocytogenes after exposure to moderate salt content or lime juice could represent enhanced virulence and adhesion capabilities, posing a significant public health risk.
Developing an empathic analysis: Using critical literacy, dialogue, and inquiry with literature to explore the issues with gender labels
Authors: Savitz Rachelle S. , Irvin Vanessa , Soulen Rita Reinsel 
Published: February 2024

AbstractBook banning and censorship in the U.S. prompts necessary conversations on how critical literacy, dialogue, and inquiry are used in various school and library settings. We share guiding questions alongside three examples of textual analyses centering on gender fluidity with three young adult novels. We believe that English language arts teachers will benefit from seeing examples of how we responded to these texts with critical analysis questions that require students to analyze gender representation and identity within the stories. By developing an empathic analysis, students can engage in this critical work within classrooms and libraries, where reading diverse texts is encouraged.
2023 update to the American College of Clinical Pharmacy Pharmacotherapy Didactic Curriculum Toolkit
Authors: Kolanczyk Denise M. , Merlo Jessica R. , Bradley Bridget , Flannery Alexander H. , Gibson Caitlin M. , McBane Sarah , Murphy Julie A. , Noble Jacob M. , Noble Melissa B. , Patton Hunter M. , Rosselli Jennifer L. , Stone Rebecca H. , Thornby Krisy‐Ann 
Published: February 2024

AbstractThe American College of Clinical Pharmacy (ACCP) Pharmacotherapy Didactic Curriculum Toolkit has been used by colleges and schools of pharmacy as a guide for curricular development and revisions since its inaugural publication in 2009. The toolkit was last revised and updated by the 2019 Publications Committee. The 2023 ACCP Publications Committee was charged with reviewing the 2019 Update to the ACCP Pharmacotherapy Didactic Curriculum Toolkit to determine any necessary revisions/updates. The committee revised tier classifications, shifting the focus of the 2023 toolkit to content within the Pharm.D. curriculum. Multiple literature sources were reviewed to assess conditions for inclusion in the 2023 toolkit, and external feedback was solicited from various practice disciplines. All topics were voted on by a simple majority rule during virtual meetings or by electronic votes. There are a total of 231 topics in the 2023 toolkit, a decrease of 77 (23.2%) from the 2019 edition. Topics in each tier are as follows: 68 as tier 1 (29%), 111 as tier 2 (48%), and 52 as tier 3 (23%). Although some topics were removed completely, others were combined with other line items or revised, which may further minimize curricular overload. Similar to the 2016 and 2019 toolkits, many tier 2 topics remain in the 2023 toolkit, emphasizing the continued need for additional training through postgraduate residencies or fellowships (or “on‐the‐job” equivalent experiences), board certifications, and various certificate training programs. The 2023 ACCP Pharmacotherapy Didactic Curriculum Toolkit is designed to assist individual faculty and colleges and schools of pharmacy with curricular development and revisions. It will continue to be reviewed every 3 years to identify needed revisions on the basis of the pharmacist's evolving role, advances in therapeutics and pharmacy practice, and changes to accreditation standards and recognized professional competencies.
Investigation of two dimensional‐MoS2/reduced graphene oxide electrode for applications of NOx gas sensors
Authors: Chiu Sheng‐Kuei , Tang Chih‐Chieh , Louh Rong‐Fuh 
Published: February 2024

AbstractIntroductionTo generate GO and rGO nanoparticles, high‐temperature thermal reduction and the Hummers' technique were both employed. A GO sample is heated and turned into rGO nanopowder. A MoS2 precursor is then added to make a MoS2/rGO composite structure.ObjectivesThe themes of this research work consist of (1) preparation of molybdenum disulfide (MoS2) powder produced by hydrothermal method and sulfurization reaction; (2) graphene oxide (GO) nanoparticles prepared by Hummers' method, compounded with MoS2 to form molybdenum disulfide/reduced graphene oxide (MoS2/rGO) powder in order to reduce the working temperature of a gas sensing process; (3) evaluation of effects of MoS2 and MoS2/rGO sensing devices for NO and NO2 (NOx) gas detection.Results and conclusionWhen tested under various gas concentration and ambient temperature conditions, the NOx gas concentration is 10 ppm, and the working temperature is 150°C, the response value obtained reaches 14.4. In this study, MoS2; a member of two‐dimensional (2D) transition metal sulfide materials, was applied as the main body of the sensing material, and rGO was used as a functional additive. For creating new gas sensing devices, significant progress has been made in creating and designing NOx gas sensing devices for MoS2/rGO composite materials.
Learning on the country: Motivating dental students to attend a rural placement
Authors: Swift Hazel , Farhang Tina , Georgei Maribelle , Lalloo Ratilal 
Published: February 2024

AbstractPurpose/objectivesThis research aimed to identify factors that affect dental students’ attitudes toward participation in rural clinical outplacements (RCOP) in Australia, and to suggest strategies that will increase students' desire to attend RCOP in the future.MethodsDental students from the nine dental schools in Australia were invited to an online survey on their willingness to participate in an RCOP and the factors that influence this willingness. These factors were grouped into themes of education, personal and health, social, financial, and information‐related.ResultsThe study had an estimated response rate of 10% with 202 responses. More than two‐thirds (68%) of students were willing to participate in an RCOP. Students who grew up in a rural area were significantly more likely to be willing to attend an RCOP, compared to those from urban settings. Attitudes toward the anticipated educational experience of RCOP were positive, while factors related to finances and pre‐existing information were of concern to students. Educational, personal/health‐related, and social factors had significant impacts on participants' willingness to attend RCOP.ConclusionOverall, despite students holding negative opinions on certain social and financial factors, their positive attitudes toward other factors outweighed these. Universities should aim to further promote the educational benefits of RCOP to improve students’ attitudes prior to attending RCOP. In‐depth qualitative analysis is required to explore students’ concerns regarding RCOP and longitudinal research is warranted to monitor students’ attitudes toward RCOP and rural work over time.
Nucleotide metabolism, leukodystrophies, and CNS pathology
Authors: Gavazzi Francesco , Gonzalez Carlos Dominguez , Arnold Kaley , Swantkowski Meghan , Charlton Lauren , Modesti Nicholson , Dar Asif A. , Vanderver Adeline , Bennett Mariko , Adang Laura A. 
Published: February 2024

AbstractThe balance between a protective and a destructive immune response can be precarious, as exemplified by inborn errors in nucleotide metabolism. This class of inherited disorders, which mimics infection, can result in systemic injury and severe neurologic outcomes. The most common of these disorders is Aicardi Goutières syndrome (AGS). AGS results in a phenotype similar to “TORCH” infections (Toxoplasma gondii, Other [Zika virus (ZIKV), human immunodeficiency virus (HIV)], Rubella virus, human Cytomegalovirus [HCMV], and Herpesviruses), but with sustained inflammation and ongoing potential for complications. AGS was first described in the early 1980s as familial clusters of “TORCH” infections, with severe neurology impairment, microcephaly, and basal ganglia calcifications (Aicardi & Goutières, Ann Neurol, 1984;15:49–54) and was associated with chronic cerebrospinal fluid (CSF) lymphocytosis and elevated type I interferon levels (Goutières et al., Ann Neurol, 1998;44:900–907). Since its first description, the clinical spectrum of AGS has dramatically expanded from the initial cohorts of children with severe impairment to including individuals with average intelligence and mild spastic paraparesis. This broad spectrum of potential clinical manifestations can result in a delayed diagnosis, which families cite as a major stressor. Additionally, a timely diagnosis is increasingly critical with emerging therapies targeting the interferon signaling pathway. Despite the many gains in understanding about AGS, there are still many gaps in our understanding of the cell‐type drivers of pathology and characterization of modifying variables that influence clinical outcomes and achievement of timely diagnosis.
The multilevel well‐being paradox: Towards an integrative process theory of coping in teams
Authors: Nordbäck Emma , Nurmi Niina , Gibbs Jennifer L. , Boyraz Maggie , Logemann Minna 
Published: February 2024

SummaryContemporary work teams are increasingly faced with external pressures and changing demands that thrust them into stressful conditions that require coping to maintain not only performance but also well‐being. In this paper, we treat the COVID‐19 pandemic as an extreme case of multilevel stressors and coping in teams to investigate how teams and their members simultaneously cope with stressors at both individual and team levels and the impacts this has on their well‐being. We conducted a longitudinal qualitative multi‐case study involving 12 teams, utilizing data from 69 members collected through diaries, interviews, and surveys over a period of 6 months. Our findings illustrate how the needs and coping efforts of teams and individuals can sometimes conflict, resulting in opposing states of well‐being at different levels. We frame this phenomenon as the multilevel well‐being paradox. Our emergent process model of multilevel coping in teams suggests that teams thrive when they establish a shared appraisal of stressors and coping options through active team reflection, and when they adopt coping approaches that align with the specific stressors experienced at both levels. This study advances our understanding of coping in teams by illuminating the intricate interplay between team and individual well‐being and highlighting the paradoxical nature of this relationship.
Seek and ye shall find: The utility of perioperative VTE screening in high‐risk oncologic patients undergoing abdominopelvic surgery
Authors: Pletcher Eric R. , Nguyen‐Thai Allison , Lim Tiffany , Silberman Allan W. 
Published: February 2024

AbstractBackground and ObjectiveThe aim of this study was to evaluate the prevalence and risk factors associated with perioperative venous thromboembolism (VTE) in patients undergoing major oncologic surgery using an epidural catheter (EC) for postoperative analgesia with mechanical prophylaxis and without chemoprophylaxis.MethodsSix hundred and twenty‐six patients undergoing major oncologic surgery from 2009 to 2023 were evaluated. VTE was defined as deep vein thrombosis above the level of the knee. Lower extremity venous duplexes (LEVDs) were done preoperatively and postoperatively after the EC was removed. All patients received mechanical thromboprophylaxis, but not chemical prophylaxis, while the EC was in place. A generalized linear multivariable model was constructed to identify risk factors that predict pre and postoperative VTE.Results29/626 patients (4.6%) were found to have preoperative VTE. 16/626 (2.6%) were found to have a postoperative VTE when their preoperative LEVD was negative. In comparison to patients without preoperative VTE, those with VTE were more likely to be male, anticoagulated, and have a history of coronary artery disease. Patients in the postoperative VTE group were older, male, anticoagulated, and had a history of VTE. On multivariable analysis, previous history of VTE was the risk factor most strongly associated with both pre and postoperative VTE.ConclusionOncologic patients undergoing elective abdominopelvic surgery with epidural analgesia should be screened in the perioperative setting with LEVD to identify VTE and possibly prevent PE.
Artificial intelligence in head and neck surgery: Potential applications and future perspectives
Authors: Wojtera Bartosz , Szewczyk Mateusz , Pieńkowski Piotr , Golusiński Wojciech 
Published: February 2024

AbstractArtificial intelligence (AI) has the potential to improve the surgical treatment of patients with head and neck cancer. AI algorithms can analyse a wide range of data, including images, voice, molecular expression and raw clinical data. In the field of oncology, there are numerous AI practical applications, including diagnostics and treatment. AI can also develop predictive models to assess prognosis, overall survival, the likelihood of occult metastases, risk of complications and hospital length of stay.
Bilateral Costal Cartilage Harvest for Auricle Reconstruction: A New Technique to Prevent Postoperative Thoracic Deformity
Authors: Wang Peizhou , Chen Qi , Wang Bingqing , Wang Yue , Zhang Qingguo , Luo Pan 
Published: February 2024

HypothesisUnilateral costal cartilage harvesting (UCCH) for auricle reconstruction in children tends to cause thoracic deformities. Therefore, our study aimed to develop a novel bilateral costal cartilage harvesting (BCCH) method to prevent and reduce thoracic deformities.MethodsPatients with unilateral microtia who underwent either UCCH (n = 50) or BCCH (n = 46) were enrolled in this study. The grafts for the BCCH group were harvested from the 6th costal cartilage of the ipsilateral hemithorax and the 7th and 8th cartilage from the other hemithorax. Computed tomography and physical examination were performed to identify any physical deformities in the chest contours post‐surgery. The cosmetic appearance of the thoracic scars post‐surgery was evaluated using the Scar Cosmesis Assessment and Rating Scale (SCAR) and Visual Analogue Scales (VAS cosmetic). The numerical rating scale (NRS) was used to quantify the pain in donor sites. The reconstructed ears were assessed during the follow‐up period.ResultNone of the patients in the BCCH group developed thoracic deformities, while 16 patients within the UCCH group developed mild (n = 12) or severe (n = 4) thoracic deformities (p < 0.001). The SCAR (3.09 vs. 2.92, p = 0.580) and VAS scores (0.96 vs. 0.90, p = 0.813) did not differ significantly between the two groups. For both treatment arms, the NRS scores were highest on the first‐day post‐surgery and gradually dropped over the 10 days. No significant differences were found in the NRS scores and the aesthetic outcomes of the reconstructed ears between the two groups.ConclusionThe BCCH method effectively reduced the incidence of thoracic deformity at the donor site without increasing postoperative pain and cosmetic concerns for patients. It could be used clinically to improve patient outcomes of costal cartilage grafts.Level of Evidence4 Laryngoscope, 134:3572–3580, 2024
Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias
Authors: Lai Ruo‐Yah , Rummey Christian , Amlang Christian J. , Lin Chi‐Ying R. , Chen Tiffany X. , Perlman Susan , Wilmot George , Gomez Christopher M. , Schmahmann Jeremy D. , Paulson Henry , Ying Sarah H. , Onyike Chiadi U. , Zesiewicz Theresa A. , Bushara Khalaf O. , Geschwind Michael D. , Figueroa Karla P. , Pulst Stefan M. , Subramony Sub H. , Burns Matthew R. , Opal Puneet , Duquette Antoine , Ashizawa Tetsuo , Hamedani Ali G. , Davis Marie Y. , Srinivasan Sharan R. , Moore Lauren R. , Shakkottai Vikram G. , Rosenthal Liana S. , Kuo Sheng‐Han 
Published: February 2024

ABSTRACTBackgroundFatigue is a prevalent and debilitating symptom in neurological disorders, including spinocerebellar ataxias (SCAs). However, the risk factors of fatigue in the SCAs as well as its impact have not been well investigated.ObjectivesTo study the prevalence of fatigue in SCAs, the factors contributing to fatigue, and the influence of fatigue on quality of life.MethodsFatigue was assessed in 418 participants with SCA1, SCA2, SCA3, and SCA6 from the Clinical Research Consortium for the Study of Cerebellar Ataxia using the Fatigue Severity Scale. We conducted multi‐variable linear regression models to examine the factors contributing to fatigue as well as the association between fatigue and quality of life.ResultsFatigue was most prevalent in SCA3 (52.6%), followed by SCA1 (36.7%), SCA6 (35.7%), and SCA2 (35.6%). SCA cases with fatigue had more severe ataxia and worse depressive symptoms. In SCA3, those with fatigue had a longer disease duration and longer pathological CAG repeat numbers. In multi‐variable models, depressive symptoms, but not ataxia severity, were associated with more severe fatigue. Fatigue, independent of ataxia and depression, contributed to worse quality of life in SCA3 and SCA6 at baseline, and fatigue continued affecting quality of life throughout the disease course in all types of SCA.ConclusionsFatigue is a common symptom in SCAs and is closely related to depression. Fatigue significantly impacts patients' quality of life. Therefore, screening for fatigue should be considered a part of standard clinical care for SCAs.
Liquid‐level sensor based on Michelson interferometer with double hook structure
Authors: Mao Beibei , Wu Yongfeng , Cheng Weihao , Ullah Rahat , Ren Jianxin , Mao Yaya , Yuan Tingxuan , Wang Tutao 
Published: February 2024

AbstractA new type of Michelson interferometer (MI) based on a double hook structure is proposed for measurement of liquid level and temperature. The optical fiber MI based on the double‐hook structure is fabricated using a hydroxide flame heating device. Furthermore, the angle and sensing length of the double‐hook structure can be controlled by a rotating platform. The sensor is fixed on a ruler, which is set vertically on the iron support stand employing a beaker clamp, and the position of the beaker clamp is adjusted so that the double hook structure of the sensor overflows the water surface in the beaker. The temperature and liquid level sensitivities of the sensor are 129.8 pm/°C and −186.2 pm/mm, respectively. The novel optical fiber MI based on the double‐hook structure has the advantages of high sensitivity, low cost and easy fabrication, which has a great market prospect in production and life.
Lehre in der organischen Chemie individualisieren
Authors: Martin Paul P. , Graulich Nicole 
Published: February 2024

AbstractMit künstlicher Intelligenz lassen sich Freitextantworten automatisiert auswerten. Dies erleichtert, den Lernfortschritt jedes Lernenden zu verfolgen und Lernmaterialien in individualisierten Lernumgebungen anzupassen.
Prozessanlagen: Wissen wo welche Wolke Wabert
Authors: Braun René 
Published: February 2024

AbstractEin Start‐up aus Brandenburg hat ein optisches System entwickelt, das gasförmige Gefahrstoffe aus großer Entfernung erkennt. Dies verkürzt für Unternehmen die Reaktionszeit bei Unfällen und macht Industrieanlagen sicherer.
Lebenszyklusanalyse: Unverzichtbares Wissen
Authors: Schappel Jörg 
Published: February 2024

AbstractPolitik und Gesellschaft fordern transparente Lieferketten, um die Nachhaltigkeitsziele der Vereinten Nationen zu erreichen. Unternehmen müssen daher Klimaschutz mit messbaren Taten umsetzen.
French grassroots volunteer organizations and prospective: Challenges and avenues for nonprofit research
Authors: Plaisance Guillaume 
Published: February 2024

AbstractThis article explores the importance of prospective for practitioners in the sector of grassroots volunteer organizations (GVOs, as associations). Prospective can be defined as an attitude of studying the future that must lead to action. In this, in times of crisis, prospective seems crucial and the GVOs' point of view can open a research agenda. The French case of GVOs deserves more attention because of their characteristics (e.g., 90% of GVOs have no employees, 75% of them have an annual budget of less than 10,000 euros), their relationship with the public authorities and their strong social impact on the community. The scenarios of evolution of the GVOs sector proposed by La Fonda are analyzed and become filters for the reading of the French literature dedicated to GVOs. They lead to four lines of research (isomorphism; normalization and standardization; evaluation and impact; organizational capacities). Following this, a research agenda dedicated to French GVOs is proposed. This work has intrinsic implications, conducting a literature review and proposing a research agenda compared to international agendas. It highlights the challenges GVOs face and the differences between desirable research in France and international research agendas. It constitutes possible inspirations for GVOs leaders thanks to a synoptic table.
Nanoclay particles as a stem cell adhesion factor in polyvinyl alcohol hydrogel‐based wound dressings
Authors: Renani Mohammad Mojmeli , Nazarpak Masoumeh Haghbin , Solati‐Hashjin Mehran , Mahdavi Hamid 
Published: February 2024

AbstractAs the primary goal in the wound care intervention is the promotion of rapid wound healing, researchers sought to find a remedy. In this progression course, nanocomposite‐based hydrogels have attracted the attention. Herein, we used a polyvinyl alcohol (PVA) hydrogel in combination with two forms of clay nanoparticles, namely unmodified montmorillonite (MONT) and modified (OMONT), to fabricate a nanocomposite‐based hydrogels and combat the lack of stem cells' adhesion to PVA, followed by seeding of adipose‐derived stem cells (ADSCs) on them. To investigate the characteristics of these constructs, corresponding tests were performed. The Young's modulus and elongation at break of PVA/5% OMONT were 3.7 ± 0.014 and 800 ± 35, respectively, which were higher than those of PVA/5% MONT (3 ± 0.03 and 320 ± 14). In addition, the hardness of the modified group (7.2 ± 0.07) was lower than the unmodified one (9.8 ± 0.07). The water vapor transmission rate (WVTR) in the OMONT group was 39 ± 0.28, which was lower than PVA/5% MONT (46 ± 4.24). Hence, ADSCs/PVA montmorillonite dressing may improve wound healing and provide a new way to employ stem cells, significantly impacting skin tissue engineering safely.Highlights
Modified montmorillonite had higher stem cell binding.
The lack of stem cells' adhesion to polyvinyl alcohol (PVA) was solved.
Adipose‐derived stem cells/PVA montmorillonite dressing may improve wound healing.
It is a novel promising approach for skin tissue engineering.