bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing engineering students’ engagement in academic writing classes using corpus-based instruction
Authors: Birhan Amare Tesfie , Nurie Yenus 
Published: March 2024

AbstractEngagement is a core issue in language teaching and learning. Without the students’ active involvement in the teaching–learning process, educational objectives could not be achieved. Accordingly, the concept of engagement has been the focus of researchers, practitioners, and policymakers. This research examined the effects of corpus-based instruction on engineering students’ engagement in academic writing classes. The participants were 77 randomly selected fourth-year mechanical engineering students. The data were gathered through a self-reflective report and a journal and analyzed through an independent t-test, One-Way ANOVA, and narration techniques. The data showed that students who were instructed via corpus-based instruction improved their behavioral, emotional, and cognitive engagements better than their counterparts; the experimental group enjoyed the activities and actively participated in different academic writing processes. The data also attested that there was a significant statistical difference between the experimental group and the control group engagements. This research implied that EFL teachers should consider genuine and real-life linguistic features and activities when they design academic writing instruction to enhance their engagement during the instruction.
Possible role of cardiovascular stress induced by the volume load as a cause of anemia in hemodialysis patients: a case of a maintenance hemodialysis patient with a literature review
Authors: Daimon Shoichiro 
Published: March 2024

Abstract
Background
Although a deficiency in erythropoietin relative to decreased hemoglobin levels is presumed to be the predominant cause of renal anemia, other factors may also exist that are not fully understood.

Case presentation
A 58-year-old man with pyelonephritis who had been on hemodialysis for 18 years presented a gradually decreasing serum creatinine level, possibly due to voluntary dietary restrictions, accompanied by a gradual increase in the cardiothoracic ratio from 48% to 56%. Concomitantly, his hemoglobin level decreased gradually from 14.5 to 8.7 g/dL by 6 months. Although he had no symptoms of heart failure and his left ventricular ejection fraction was 66.3%, which was almost identical to his condition 2 years prior, a drastic reduction in posthemodialysis body weight from 71.0 to 68.6 kg in 9 days was performed without apparent intrahemodialysis hypotension. His cardiothoracic ratio and serum prehemodialysis N-terminal pro-brain natriuretic peptide level decreased steeply, from 56% to 49% by 2 weeks and from 6139 to 647 pg/mL by 8 weeks, followed by a gradual increase in his hemoglobin level from 8.7 to 15.1 g/dL by 3 months. The patient was administered 50 mg/day sodium ferrous citrate but no erythropoietin-stimulating agents or hypoxia-inducible factor prolyl hydroxylase inhibitors. Although a modest increase in the serum protein level was observed immediately after the rapid reduction in posthemodialysis body weight, the patient’s hemoglobin level increased markedly and gradually, suggesting an improvement in anemia rather than hemoconcentration.

Conclusions
Cardiovascular stress induced by the volume load is one of the causes of anemia in hemodialysis patients.
Preclinical characterisation of gallium-68 labeled ferrichrome siderophore stereoisomers for PET imaging applications
Authors: Krasulova Kristyna , Neuzilova Barbora , Dvorakova Bendova Katerina , Novy Zbynek , Popper Miroslav , Hajduch Marian , Petrik Milos 
Published: March 2024

Abstract
Background
Siderophores are small iron-binding molecules produced by microorganisms to facilitate iron acquisition from the environment. Radiolabelled siderophores offer a promising solution for infection imaging, as they can specifically target the pathophysiological mechanisms of pathogens. Gallium-68 can replace the iron in siderophores, enabling molecular imaging with positron emission tomography (PET). Stereospecific interactions play a crucial role in the recognition of receptors, transporters, and iron utilisation. Furthermore, these interactions have an impact on the host environment, affecting pharmacokinetics and biodistribution. This study examines the influence of siderophore stereoisomerism on imaging properties, with a focus on ferrirubin (FR) and ferrirhodin (FRH), two cis–trans isomeric siderophores of the ferrichrome type.

Results
Tested siderophores were labelled with gallium-68 with high radiochemical purity. The resulting complexes differed in their in vitro characteristics. [68Ga]Ga-FRH showed less hydrophilic properties and higher protein binding values than [68Ga]Ga-FR. The stability studies confirmed the high radiochemical stability of both [68Ga]Ga-siderophores in all examined media. Both siderophores were found to be taken up by S. aureus, K. pneumoniae and P. aeruginosa with similar efficacy. The biodistribution tested in normal mice showed rapid renal clearance with low blood pool retention and fast clearance from examined organs for [68Ga]Ga-FR, whereas [68Ga]Ga-FRH showed moderate retention in blood, resulting in slower pharmacokinetics. PET/CT imaging of mice injected with [68Ga]Ga-FR and [68Ga]Ga-FRH confirmed findings from ex vivo biodistribution studies. In a mouse model of S. aureus myositis, both radiolabeled siderophores showed radiotracer accumulation at the site of infection.

Conclusions
The 68Ga-complexes of stereoisomers ferrirubin and ferrirhodin revealed different pharmacokinetic profiles. In vitro uptake was not affected by isomerism. Both compounds had uptake with the same bacterial culture with similar efficacy. PET/CT imaging showed that the [68Ga]Ga-complexes accumulate at the site of S. aureus infection, highlighting the potential of [68Ga]Ga-FR as a promising tool for infection imaging. In contrast, retention of the radioactivity in the blood was observed for [68Ga]Ga-FRH. In conclusion, the stereoisomerism of potential radiotracers should be considered, as even minor structural differences can influence their pharmacokinetics and, consequently, the results of PET imaging.
Empowering ChatGPT with guidance mechanism in blended learning: effect of self-regulated learning, higher-order thinking skills, and knowledge construction
Authors: Lee Hsin-Yu , Chen Pei-Hua , Wang Wei-Sheng , Huang Yueh-Min , Wu Ting-Ting 
Published: March 2024

AbstractIn the evolving landscape of higher education, challenges such as the COVID-19 pandemic have underscored the necessity for innovative teaching methodologies. These challenges have catalyzed the integration of technology into education, particularly in blended learning environments, to bolster self-regulated learning (SRL) and higher-order thinking skills (HOTS). However, increased autonomy in blended learning can lead to learning disruptions if issues are not promptly addressed. In this context, OpenAI's ChatGPT, known for its extensive knowledge base and immediate feedback capability, emerges as a significant educational resource. Nonetheless, there are concerns that students might become excessively dependent on such tools, potentially hindering their development of HOTS. To address these concerns, this study introduces the Guidance-based ChatGPT-assisted Learning Aid (GCLA). This approach modifies the use of ChatGPT in educational settings by encouraging students to attempt problem-solving independently before seeking ChatGPT assistance. When engaged, the GCLA provides guidance through hints rather than direct answers, fostering an environment conducive to the development of SRL and HOTS. A randomized controlled trial (RCT) was employed to examine the impact of the GCLA compared to traditional ChatGPT use in a foundational chemistry course within a blended learning setting. This study involved 61 undergraduate students from a university in Taiwan. The findings reveal that the GCLA enhances SRL, HOTS, and knowledge construction compared to traditional ChatGPT use. These results directly align with the research objective to improve learning outcomes through providing guidance rather than answers by ChatGPT. In conclusion, the introduction of the GCLA has not only facilitated more effective learning experiences in blended learning environments but also ensured that students engage more actively in their educational journey. The implications of this study highlight the potential of ChatGPT-based tools in enhancing the quality of higher education, particularly in fostering essential skills such as self-regulation and HOTS. Furthermore, this research offers insights regarding the more effective use of ChatGPT in education.
Lyme disease and Whipple’s disease: a comprehensive review for the rheumatologist
Authors: Giardini Henrique Ayres Mayrink , Neves Fabricio Souza , Pereira Ivanio Alves , Cordeiro Rafael Alves 
Published: March 2024

AbstractDespite their rarity, Lyme disease and Whipple’s disease are of significant importance in rheumatology, as both can manifest as chronic arthritis, presenting challenges in the differential diagnosis of inflammatory arthropathies. In Lyme disease, arthritis typically emerges as a late manifestation, usually occurring six months after the onset of erythema migrans. The predominant presentation involves mono- or oligoarthritis of large joints, with a chronic or remitting-recurrent course. Even with appropriate antimicrobial treatment, arthritis may persist due to inadequate immunological control triggered by the disease. In contrast, Whipple’s disease may present with a migratory and intermittent seronegative poly- or oligoarthritis of large joints, preceding classic gastrointestinal symptoms by several years. Both disorders, particularly Whipple’s disease, can be misdiagnosed as more common autoimmune rheumatic conditions such as rheumatoid arthritis and spondyloarthritis. Epidemiology is crucial in suspecting and diagnosing Lyme disease, as the condition is transmitted by ticks prevalent in specific areas of the United States, Europe, and Asia. On the contrary, the causative agent of Whipple’s disease is widespread in the environment, yet invasive disease is rare and likely dependent on host genetic factors. In addition to erythema migrans in Lyme disease and gastrointestinal manifestations in Whipple’s disease, neurological and cardiac involvement can further complicate the course of both. This article offers a comprehensive review of the epidemiological, pathophysiological, clinical, and therapeutic aspects of both diseases.
Dual-assisted high-precision tracking technique for wideband multiplexed signals in new generation GNSS
Authors: Qi Yunhan , Yao Zheng , Lu Mingquan 
Published: March 2024

AbstractWith the evolution of Global Navigation Satellite System (GNSS), new generation GNSS signals have adopted the dual-frequency multiplexing modulation techniques, which jointly modulate multiple signals located on multiple sub-frequencies into a Wideband Multiplexed Signal (WMS). Although WMSs were proposed initially to reduce the complexity of satellite transmitters and improve the transmission efficiency of signals, their multi-component structures and wide root mean square bandwidths introduced by high-frequency subcarriers also provide the possibility to improve the GNSS ranging precision. Therefore, this paper proposes a Dual-assisted Multi-component Tracking (DMT) technique, which can not only fully use high-frequency subcarriers in WMSs, but also effectively track carrier, subcarrier, and code by jointly utilizing all components in WMS. In this paper, the tracking and ranging performances of DMT are comprehensively analyzed theoretically and by simulation and real experiments. The results show that compared with existing WMS tracking methods, DMT can achieve tracking results with lower tracking jitters and ranging results with higher precision, providing a highly advantageous solution for new generation GNSS signal processing.
Autistic, schizotypal traits, and insight level in patients with obsessive–compulsive disorder
Authors: Farouk M. , Nasr M. , Khalil M. , Dozebik I. , El Makawi S. , Fakher W. , Ayoub D. R. 
Published: March 2024

Abstract
Background
Comorbid personality disorders and obsessive–compulsive disorder (OCD) range between 33 and 87%. Patients having OCD more commonly receive cluster A (the odd and eccentric cluster) compared with other nonpsychotic patients. Poor insight levels within OCD increase disease severity and impair neuropsychological factors, where OCD patients exhibit poorer speech learning and memory.

Objectives
To assess schizotypal, autistic traits, and insight levels in patients with OCD.

Methods
Forty subjects with OCD were recruited from outpatient clinics of Kasr Alainy Psychiatry and Addiction Prevention Hospital and assessed using the Dimensional Yale-Brown Obsessive–Compulsive Scale (DYBOCS), Schizotypal Personality Questionnaire-Brief Revised (SPQ-BR), and Autism Spectrum Quotient (AQ) while insight level was assessed using Brown Assessment of Beliefs Scale (BABS).

Results
Total DY-BOCS score was positively correlated with the AQ score and SPQ score. Global distress and interference subdomains of DY-BOCS were positively correlated with AQ, SPQ score, and Insight level (BABS). Indicating that the worse the insight the higher the distress and interference in daily life. Global distress and interference were also positively correlated to all subscales of SPQ. Aggressive obsessions were correlated with SPQ score, cognitive-perceptual (CP) traits, ideas of reference, and magical thinking. Contamination/cleaning obsessions were positively correlated with the level of insight (BABS). While sexual and religious obsessions were negatively correlated with the level of insight.

Conclusion
Increased severity of OCD is associated with more autistic symptoms, schizotypal symptoms, and poorer insight. No gender differences in OCD patients regarding severity, autistic symptoms, schizotypal symptoms, or insight.
Building a communication and support network among quality improvement teams in nursing homes: a longitudinal study of the SCOPE trial
Authors: Yousefi Nooraie Reza , Qin Qiuyuan , Wagg Adrian , Berta Whitney , Estabrooks Carole 
Published: March 2024

Abstract
Background
We applied a longitudinal network analysis approach to assess the formation of knowledge sharing and collaboration networks among care aide-led quality improvement (QI) teams in Canadian nursing homes participating in the Safer Care for Older Persons (in residential) Environments (SCOPE) trial which aimed to support unregulated front-line staff to lead unit-based quality improvement (QI) teams in nursing homes. We hypothesized that SCOPE's communicative and participatory nature would provide opportunities for peer support, knowledge sharing, and collaboration building among teams.

Methods
Fourteen QI teams in Alberta (AB) and seventeen QI teams in British Columbia (BC) participated in the study. Communications across nursing homes occurred through a series of 4 collaborative Learning Congresses (training sessions) over a 1-year period. The senior leaders of QI teams participated in two online network surveys about the communication/collaboration between teams in their province, 1 month after the first, and 6 months later, after the fourth Learning Congress. We developed communication and collaboration network maps pertaining to three time points: before SCOPE, at 2 months, and at 9 months.

Results
Over time, teams made significantly more new connections and strengthened existing ones, within and across regions. Geographic proximity and co-membership in organizational chains were important predictors of connectivity before and during SCOPE. Teams whose members were well connected at baseline disproportionately improved connectivity over time. On the other hand, teams that did not have prior opportunities to connect appeared to use SCOPE to build new ties.

Conclusions
Our findings suggest the importance of network-altering activities to the formation of collaboration networks among QI teams across nursing homes. Active strategies could be used to better connect less connected teams and facilitate collaboration among geographically proximate teams. These findings may inform the development of interventions to leverage existing networks and provide new networking opportunities to develop and sustain organizational improvements.
Prognostic values and immune infiltration of KLF15, AQP7, AGPAT9 in glioma and glioblastoma
Authors: Olajuyin Ayobami Matthew , Nwachukwu Onyinyechi Sharon , Olajuyin Adefunke K. , Hayatu Raji M. , James Adewale , Adesupo Akinrefon , Adegoke Ayodeji Mathias , Akingbade Adebola Idowu 
Published: March 2024

Abstract
Backgrounds
The overall survival of patients with lower-grade gliomas and glioblastoma varies greatly. No reliable or existing procedures can accurately forecast survival and prognostic biomarkers for early diagnosis in glioma and glioblastoma. However, investigations are progressing in immunotherapy, tumor purity, and tumor microenvironment which may be therapeutic targets for glioma and glioblastoma.

Results
This study indicated the possible prognostic signatures that can be used to identify immune-related prognostic biomarkers in the prediction of the survival of low-grade glioma (LGG) patients which may be a possible therapeutic target. In addition, the Kaplan–Meier plot, ESTIMATE algorithm, and TIMER 2.0 analysis indicated that Krüppel-like factor 15 (KLF15) p = 0.030, Aquaporin 7 (AQP7) p = 0.001, and Human 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9) p = 0.005 are significantly associated in glioma. Hence, they may be possible prognostic biomarkers in glioma. Meanwhile, in the glioblastoma, only KLF15 has a significant association with glioblastoma (p = 0.025). Stromal and immune scores of gliomas were determined from transcriptomic profiles of LGG cohort from TCGA (The Cancer Genome Atlas) using the ESTIMATE (Estimation of Stromal and Immune cells in Malignant Tumours using Expression data algorithm). The immune infiltration of the KLF15, AQP7, and AGPAT9 for low-grade glioma and glioblastoma was determined using TIMER immune 2.0 which indicates correlation with tumor purity for KLF15, AQP7, and AGPAT9, but only KLF15 and AGPAT9 are significantly associated in both glioma and glioblastoma, respectively.

Conclusions
These results highlight the significance of microenvironment monitoring, analysis of glioma and glioblastoma prognosis, and targeted immunotherapy. To our knowledge, this is the first time to investigate an analysis that revealed that KLF15, AQP7, and AGPAT9 may be important prognostic biomarkers for patients with glioma and KLF15 for patients with glioblastoma. Meanwhile, KLF15 and AGPAT9 are significantly associated in both glioma and glioblastoma, respectively, for tumor purity.
Renal amyloidosis: a hidden complication of celiac disease (a case report)
Authors: Kaouiri Zaineb , Ftaimi Ikram , Benbella Meryem , Bayahia Rabia , Benamar Loubna , Ouzeddoun Naima , Bouattar Tarik 
Published: March 2024

AbstractWe report a case of a 36-year-old female with untreated celiac disease, exhibiting both digestive discomfort and extra-digestive symptoms, including anemia. She subsequently developed a nephrotic syndrome. Biopsy of the accessory salivary gland confirmed amyloid deposits, as indicated by positive Congo red staining. Esophagogastroduodenal fibroscopy revealed characteristic signs of celiac disease and ruled out lymphoma. Further etiological screening identified celiac disease as the only possible cause of the amyloidosis. Complete remission was achieved after 3 months on a gluten-free diet, with later laboratory assessments indicating the absence of nephrotic syndrome and hematological abnormalities.
Profiling triglyceride-glucose index in Filipinos with type 2 diabetes mellitus: a single-center study
Authors: Flake Chastene Christopher , Morales-Valenzuela Madonna , Tiongco Raphael Enrique , Navarro Annalyn 
Published: March 2024

Abstract
Background
In this study, we evaluated the utility of the TyG index among Filipino patients with type 2 diabetes mellitus (T2DM) and explored its association with various laboratory markers.

Methods
An analytical cross-sectional study was conducted by retrospectively obtaining data from the medical records of 109 Filipino T2DM patients from a tertiary level teaching hospital. Data obtained were then statistically analyzed.

Results
Results revealed an overall TyG index of 9.15 ± 0.71 among the participants. A significant dose-response relationship was observed between the TyG index and HbA1c. The AUC result has an acceptable discriminating ability among patients with varying glycemic control. The optimal cut-off value of >8.4 has a sensitivity of 92.5% and a specificity of 47.1% in identifying patients with poor glycemic control.

Conclusion
Overall, our findings show the potential of TyG index in glycemic control assessment among Filipinos with T2DM. However, further analysis must be performed to verify its clinical utility and applicability in different populations.
Methodology for calculating load capacity reduction and slip relationship of clustered group nail connectors
Authors: Wang Shichao , Tang Chenhao , Fu Yanqing , Zhu Jianrui , Di Jianping , Li Guodong 
Published: March 2024

AbstractClustered group nail connectors are key connecting components for the full lifecycle construction and safe operation of steel–concrete composite structural bridges. To thoroughly investigate the stress mechanism of clustered group nail connectors in steel–concrete composite structures, this paper conducts a detailed numerical analysis on 100 sets of such connectors. It analyzes the stress mechanism of individual nail connectors and quantitatively calculates the group nail effect under the coupled action of multiple factors (nail spacing between layers, number of nail layers, concrete strength). Based on clarifying the force transmission patterns of nails and concrete in different layers during the loading process, this paper proposes a method for calculating the average bearing capacity reduction coefficient and the load-slip curve of single nails in clustered group nail connectors under the coupled action of multiple factors, which has been validated by experimental data. This research provides a theoretical basis for the design and calculation of group nail connectors in steel–concrete composite structural bridges.