bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methicillin resistance in Staphylococcus pseudintermedius encoded within novel staphylococcal cassette chromosome mec (SCCmec) variants
Authors: MacFadyen A C , Paterson G K 
Published: April 2024

Abstract

Background
Staphylococcus pseudintermedius is a common opportunistic pathogen of companion dogs and an occasional human pathogen. Treatment is hampered by antimicrobial resistance including methicillin resistance encoded by mecA within the mobile genetic element SCCmec.

Objectives
SCCmec elements are diverse, especially in non-Staphyloccocus aureus staphylococci, and novel variants are likely to be present in S. pseudintermedius. The aim was to characterize the SCCmec elements found in four canine clinical isolates of S. pseudintermedius.

Material and methods
Isolates were whole-genome sequenced and SCCmec elements were assembled, annotated and compared to known SCCmec types.

Results and discussion
Two novel SSCmec are present in these isolates. SCCmec7017-61515 is characterized by a novel combination of a Class A mec gene complex and a type 5 ccr previously only described in composite SCCmec elements. The other three isolates share a novel composite SCCmec with features of SCCmec types IV and VI.

Conclusions
S. pseudintermedius is a reservoir of novel SSCmec elements that has implications for understanding antimicrobial resistant in veterinary and human medicine.
Performance of disk diffusion method for aztreonam in combination with avibactam against Enterobacteriales
Authors: Yin Dandan , Song Peipei , Jiang Lan , Xu Jian , Hu Fupin 
Published: April 2024

Abstract

Objectives
To evaluate the performance of an in-house developed disk diffusion method for aztreonam in combination with avibactam against Enterobacteriales.

Methods
The in vitro antibacterial activity of aztreonam with avibactam against 204 carbapenemase-producing Enterobacteriales was determined by a disk diffusion method, with a broth microdilution method as a reference.

Results
The optimal S/R breakpoints for disk diffusion tests of 30/20 and 10/4 µg disks, calculated by the dBETs software using the model-based approaches, were ≥22/≤21 and ≥12/≤11 mm, respectively. On the basis of the estimated breakpoints, the CAs for disk diffusion tests of 30/20 and 10/4 µg aztreonam/avibactam disks were both 98.0%, with 0.5% major error and 37.5% very major error.

Conclusions
The home-made disk diffusion method is an economical and practical method for clinical microbiology laboratories to determine the antibacterial susceptibility of aztreonam with avibactam against Enterobacteriales.
Denosumab discontinuation: COVID-19 pandemic and beyond
Authors: Minisola Salvatore 
Published: April 2024

Abstract
The coronavirus disease 2019 (COVID-19) pandemic triggered significant disruptions in health care systems around the world, with a particularly heavy impact on patients with chronic diseases. A number of studies have shown an immediate decrease in on-time denosumab therapy at the start of COVID-19 pandemic. However, independent of the “emergency” that occurred during the COVID-19 pandemic, there are other situations in which denosumab is discontinued. In such situations, it is important to have a programmed strategy to optimize care while limiting the risk for unwanted outcomes.
Mining themes, emotions, and stance in the news coverage of the Russia–Ukraine War from Reuters and Xinhua
Authors: Jiang Zhaokun 
Published: April 2024

Abstract
The Russia–Ukraine War has emerged as a highly contentious global issue since 2022. While China and the UK are not directly involved in the conflict, considerable attention has been drawn to their positions and perspectives on this event. In such context, conducting a comparative study on how the British and Chinese mainstream media cover the Russia–Ukraine conflict can provide valuable insights into the influence of ideological differences on news framing and shed light on the respective stances of these two news agencies. Employing an interdisciplinary methodology, this study integrates corpus tools, critical discourse analysis, text mining, and emotion computation to systematically analyze news reports covering the Russia–Ukraine War from Reuters and Xinhua between 2022 and 2023. Results show different patterns in the news reports from the two investigated news agencies, including the monthly publication of news articles, the occurrence of prominent entities, and the thematic emphasis. Additionally, significant variations are identified in specific dimensions of emotion and emotional intensity, indicating the divergent stances of the two news agencies on a range of significant issues.
Meaning and identity of proofs in a bilateralist setting: A two-sorted typed Lambda-calculus for proofs and refutations
Authors: Ayhan Sara 
Published: April 2024

Abstract
In this paper, I will develop a $\lambda $-term calculus, $\lambda ^{2Int}$, for a bi-intuitionistic logic and discuss its implications for the notions of sense and denotation of derivations in a bilateralist setting. Thus, I will use the Curry–Howard correspondence, which has been well-established between the simply typed $\lambda $-calculus and natural deduction systems for intuitionistic logic, and apply it to a bilateralist proof system displaying two derivability relations, one for proving and one for refuting. The basis will be the natural deduction system of Wansing’s bi-intuitionistic logic 2Int, which I will turn into a term-annotated form. Therefore, we need a type theory that extends to a two-sorted typed $\lambda $-calculus. I will present such a term-annotated proof system for 2Int and prove a Dualization Theorem relating proofs and refutations in this system. On the basis of these formal results, I will argue that this gives us interesting insights into questions about sense and denotation as well as synonymy and identity of proofs from a bilateralist point of view.
Kant’s Fantasy
Authors: Russell Francey 
Published: April 2024

Abstract
Throughout his lectures and published writings on anthropology, Kant describes a form of unintentional, unstructured, obscure, and pleasurable imaginative mental activity, which he calls fantasy (Phantasie), where we ‘take pleasure in letting our mind wander about in obscurity’ (LA 25:480). In the context of his pragmatic anthropology, Kant is concerned not only to describe this form of mental activity as a fact of human psychology, but more importantly, to criticize and discourage it. But must we share Kant’s negative evaluation? Could fantasy play a positive role in some kinds of experience? In this paper I first reconstruct Kant’s conception of fantasy, and then consider what role fantasy might play in aesthetic experience. Precisely because of his anxieties about fantasy, Kant is careful to distinguish between the lawless freedom of the imagination in fantasy and the ‘free lawfulness’ of the imagination in aesthetic judgment. Departing from Kant, and with help from Susan Sontag, I argue that certain aesthetic objects, especially certain works of modernist art, positively invite fantasy, making fantasy part of proper aesthetic appreciation. I conclude by suggesting that while fantasy can indeed play a positive role in aesthetic appreciation, there is still reason to regard fantasy as ‘normatively ambiguous’.
CONGRuENTS (COsmic-ray, Neutrino, Gamma-ray and Radio Non-Thermal Spectra) – II. Population-level correlations between galactic infrared, radio, and γ-ray emission
Authors: Roth Matt A , Krumholz Mark R , Crocker Roland M , Thompson Todd A 
Published: April 2024

ABSTRACT
Galaxies obey a number of empirical correlations between their radio, γ-ray, and infrared emission, but the physical origins of these correlations remain uncertain. Here, we use the CONGRuENTS model for broad-band non-thermal emission from star-forming galaxies, which self-consistently calculates energy-dependent transport and non-thermal emission from cosmic ray hadrons and leptons, to predict radio and γ-ray emission for a synthetic galaxy population with properties drawn from a large deep-field survey. We show that our synthetic galaxies reproduce observed relations such as the far infrared (FIR)–radio correlation, the FIR–γ correlation, and the distribution of radio spectral indices, and we use the model to explain the physical origins of these relations. Our results show that the FIR–radio correlation arises because the amount of cosmic ray electron power ultimately radiated as synchrotron emission varies only weakly with galaxy star formation rate as a result of the constraints imposed on gas properties by hydrostatic balance and turbulent dynamo action; the same physics dictates the extent of proton calorimetry in different galaxies, and thus sets the FIR–γ–ray correlation. We further show that galactic radio spectral indices result primarily from competition between thermal free–free emission and energy-dependent loss of cosmic ray electrons to bremsstrahlung and escape into galactic haloes, with shaping of the spectrum by inverse Compton, synchrotron, and ionization processes typically playing a subdominant role. In addition to explaining existing observations, we use our analysis to predict a heretofore unseen correlation between the curvature of galaxies’ radio spectra and their pion-driven γ-ray emission, a prediction that will be testable with upcoming facilities.
Avacopan’s potential to decrease MPO-ANCA titres concurrent with ameliorated activity in ANCA-associated vasculitis
Authors: Taniguchi Tomoki , Hiwa Ryosuke , Shoji Mikihito , Yamaguchi Eriho , Shirakashi Mirei , Onizawa Hideo , Tsuji Hideaki , Kitagori Koji , Nakashima Ran , Akizuki Shuji , Onishi Akira , Yoshifuji Hajime , Tanaka Masao , Morinobu Akio 
Published: April 2024

ABSTRACT
Avacopan, an orally administered C5a receptor antagonist, is effective in microscopic polyangiitis via the inhibition of neutrophil priming induced by C5a. However, the exact effect of avacopan on the production of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) is yet to be clearly established. This report presents a microscopic polyangiitis patient without major organ damage where high levels of MPO-ANCA persisted with high-dose steroid therapy and azathioprine, but the addition of avacopan led to a reduction in MPO-ANCA titres. The present case implies that avacopan-mediated inhibition of C5a may lead to a reduction in MPO-ANCA levels, thereby potentially ameliorating the pathophysiology of ANCA-associated vasculitis. Nevertheless, the impact of avacopan on MPO-ANCA production cannot be asserted solely based on this report; therefore, further examination is necessary through subgroup analysis using data from larger-scale studies.
Key transcription factors regulate fruit ripening and metabolite accumulation in tomato
Authors: Jia Huimin , Xu Yaping , Deng Yuanwei , Xie Yinhuan , Gao Zhongshan , Lang Zhaobo , Niu Qingfeng 
Published: April 2024

Abstract
Fruit ripening is a complex process involving dynamic changes to metabolites and is controlled by multiple factors, including transcription factors (TFs). Several TFs are reportedly essential regulators of tomato (Solanum lycopersicum) fruit ripening. To evaluate the effects of specific TFs on metabolite accumulation during fruit ripening, we combined CRISPR/Cas9-mediated mutagenesis with metabolome and transcriptome analyses to explore regulatory mechanisms. Specifically, we generated various genetically engineered tomato lines that differed regarding metabolite contents and fruit colors. The metabolite and transcript profiles indicated that the selected TFs have distinct functions that control fruit metabolite contents, especially carotenoids and sugars. Moreover, a mutation to ELONGATED HYPOCOTYL5 (HY5) increased tomato fruit fructose and glucose contents by approximately 20% (relative to the wild-type levels). Our in vitro assay showed that HY5 can bind directly to the G-box cis-element in the Sugars Will Eventually be Exported Transporter (SWEET12c) promoter to activate expression, thereby modulating sugar transport. Our findings provide insights into the mechanisms regulating tomato fruit ripening and metabolic networks, providing the theoretical basis for breeding horticultural crops that produce fruit with diverse flavors and colors.
Effect of chronic cyclic heat stress and supplemented inorganic and organic zinc source levels on grow-finish pig growth performance and estimated body composition
Authors: Mills Kayla M , Mahoney Julie A , Duttlinger Alan W , Elefson Sarah K , Radcliffe John S , Rambo Zachary J , Richert Brian T 
Published: April 2024

Abstract
Zinc (Zn) supplementation has proved to mitigate the effects of heat stress with varying effects evident with Zn source during acute heat events. However, the effects of Zn supplementation during long-term summer weather patterns have yet to be explored. Therefore, the objective of this study was to identify the effects of supplementation source and level of Zn to mitigate the negative effects of long-term, cyclic heat stress in finishing swine. Six hundred cross-bred pigs were housed under thermoneutral (TN) or cyclic heat (HS) conditions simulating summer heat with acute 3-d heat waves for a 70-d study. Thermoneutral conditions were 16.7 to 18.9 °C throughout the study. HS pigs were housed at the same temperature as TN from days 0 to 18, then 28 °C/24 °C for 12 h/12 h on days 18 to 21, followed by 30 °C/26.7 °C for 12 h/12 h on days 24 to 70, except during acute heat (32 to 33 °C/29 to 30 °C, 12 h/12 h) on days 21 to 24, 42 to 45, and 63 to 66. Treatments were arranged in a 2 × 6 factorial with main effects of environment (HS vs. TN) and dietary available Zn supplementation: (1) 50 mg/kg zinc oxide (ZnO), (2) 130 mg/kg ZnO, (3) 50 mg/kg of organic Zn (Availa Zn), (4) 50 mg/kg ZnO + 40 mg/kg organic Zn, (5) 50 mg/kg ZnO + 60 mg/kg organic Zn, and (6) 50 mg/kg ZnO + 80 mg/kg organic Zn. Pigs (5 pigs/pen) were blocked by initial body weight (72.2 kg) and randomly allotted to 1 of 12 temperature and diet treatment combinations across 10 replicates. Body weight and feed intake were determined at the beginning and end of each acute heat event. All pigs were ultrasonically scanned at the 10th rib (TR) to predict loin muscle area (LMA), backfat (BF), and percent lean. Data were analyzed by the MIXED procedure in SAS with pen as the experimental unit. At day 63, HS pigs were lighter (P &lt; 0.05), had lower overall average daily gain (ADG; P &lt; 0.05) and average daily feed intake (P &lt; 0.05). A diet-by-environment interaction was observed for overall ADG (P &lt; 0.05) with diet 5 HS pigs having a 3.9% reduction in ADG whereas diet 6 had 14.4% reduction in ADG, while under TN temperatures diet 6 had the greatest overall ADG of all treatments. Other diets were intermediate in their ADG under both HS and TN conditions. Pigs under HS had less BF at the TR (P &lt; 0.05) and a smaller LMA (P &lt; 0.05), and a greater calculated percent lean (P &lt; 0.05). Our results indicate that a blend of supplemental Zn sources at 50/60 mg/kg may mitigate the reduction in growth performance due to HS. While not directly contrasted, the NRC requirement of 50 mg/kg Zn may be too low to optimize finishing pig growth performance under both TN and HS conditions.
A Systematic Review of Oral Pre-exposure Prophylaxis HIV Adherence Interventions
Authors: Haines Marlene , Vandyk Amanda , Skidmore Becky , Orser Lauren , O'Byrne Patrick 
Published: April 2024

Abstract
Clinical trials of pre-exposure prophylaxis (PrEP) to prevent HIV infection have established its efficacy as upwards of 99%. Despite this, the effectiveness of this medication has been shown to be diminished by individual factors, such as medication adherence. We completed a systematic review to identify and describe interventions to improve oral PrEP adherence. Overall, 16 articles were located. Two of the articles reported on results from the same trial and were collapsed for analysis, bringing the total to 15 studies. Twelve unique PrEP adherence interventions were tested, with the most common intervention being the use of mobile phone technology, which was used in 7 (46%) of the studies. Ten (67%) studies found that medication adherence improved when participants received an intervention to support adherence. Adherence intervention strategies effectively improved PrEP adherence. Further research into PrEP adherence interventions is warranted, particularly among diverse groups.
American Association of Nurse Practitioners Research Agenda, 2023–2028
Authors: Arends Robin , Austin-Ketch Tammy , Covelli Asefeh Faraz , Davis Leslie , Hallas Donna , Kalmakis Karen , Kirkland-Kyhn Holly , Melillo Karen Devereaux , O'Reilly-Jacob Monica , Parish Abby , Rawlett Kristen , Ricciardi Richard , Tracy Christine , Winkelman Chris , Whitehouse Christina 
Published: April 2024

ABSTRACT
This report highlights the 2023–2028 American Association of Nurse Practitioners Research Agenda (AANP-RA), which focuses on the research goals of AANP as an organization and is based on its mission and strategic plan. The purpose of the AANP Research Agenda is to outline research priorities that advance the AANP Strategic Plan and concurrently address gaps in nursing science. American Association of Nurse Practitioners supports research studies that are rigorously designed and conducted using quantitative, qualitative, and mixed-methods approaches, as well as implementation science with the potential to positively impact both NP practice and patient health outcomes. The AANP-RA strategy is guided by the PEARL acronym: examining NP Practice, Education, policy Advocacy, Research, and Leadership. A discussion of each area is presented along with suggested topics.
Droplet evaporation on curved surfaces: transients of internal and external transport phenomena
Authors: Paul Arnov , Mondal Subhadeep , Dhar Purbarun 
Published: April 2024

We explore the transient evolution of thermo-fluid-dynamics of evaporating sessile droplets over curved substrates in the liquid and gaseous domains. A computational model using the Arbitrary Lagrangian-Eulerian framework is adopted. The governing equations in both liquid and gaseous domains are solved in a fully coupled manner, considering coupled effects of evaporative cooling and heat advection due to bulk fluid motion. This bulk motion in the liquid domain is caused by natural advection due to thermal actuations such as thermal Marangoni flow and buoyancy-driven convection. For the gaseous domain, the additional effects of solutal convection (due to vapour-concentration variation), Stefan flow and interfacial viscous stresses are also considered. To depict a generalized role of substrate curvature, both concave and convex surfaces with curvatures over a wide range are studied. The surface wettability effects are also explored by varying the true contact angle of the droplets. Computational predictions on evaporation rate and internal flow field are validated against experimental results from literature. The interplay of wetting state and substrate curvature is noted to substantially affect the evaporation process and its thermo-fluidics. The convex curvature significantly augments internal advection while the same is weakened over concave substrates due to altered mass loss rate. Consequently, the duration of multi-vortex Marangoni flows in the development stages of evaporation and the advection in the external gaseous domain is markedly different for different curvatures. Further, on superhydrophobic curved surfaces, the effects of re-distributed evaporative fluxes play a major role. In such cases, the reduced mass flux over a large interfacial area near the periphery expedites the stable state Marangoni and external flow features.
ViRNN: A Deep Learning Model for Viral Host Prediction
Authors: Sphabmixay Pierre , Lash Blake 
Published: April 2024

AbstractViral outbreaks are on the rise in the world, with the current outbreak of COVID-19 being among one of the worst thus far. Many of these outbreaks were the result of zoonotic transfer between species, and thus understanding and predicting the host of a virus is very important. With the rise of sequencing technologies it is becoming increasingly easy to sequence the full genomes of viruses, databases of publicly available viral genomes are widely available. We utilize a convolutional and recurrent neural network architecture (ViRNN) to predict the hosts for theCoronaviridaefamily (Coronaviruses) amongst the eleven most common hosts of this family. Our architecture performed with an overall accuracy of 90.55% on our test dataset, with a micro-average AUC-PR of 0.97. Performance was variable per host. ViRNN outperformed previously published methods like k-nearest neighbors and support vector machines, as well as previously published deep learning based methods. Saliency maps based on integrated gradients revealed a number of proteins in the viral genome that may be important interactions determining viral infection in hosts. Overall, this method provides an adaptable classifier capable of predicting host species from viral genomic sequence with high accuracy.
Physics instructors’ knowledge and use of active learning has increased over the last decade but most still lecture too much
Authors: Dancy Melissa , Henderson Charles , Apkarian Naneh , Johnson Estrella , Stains Marilyne , Raker Jeffrey R. , Lau Alexandra 
Published: April 2024

A survey of 722 physics faculty conducted in 2008 found that many physics instructors had knowledge of research-based instructional strategies (RBISs), were interested in using more, but often discontinued use after trying. Considerable effort has been made during the decade following 2008 to develop and disseminate RBISs in physics as well as change the culture within the physics community to value RBIS use and other forms of student-centered instruction. This paper uses data from a 2019 survey of 1176 physics instructors to understand the current state of RBIS use in college-level introductory physics, thus allowing us to better understand some of the impacts of these efforts on physics instruction. Results show that self-reported knowledge and use of RBISs has increased considerably and discontinuation is now relatively low. However, although the percentage of time lecturing is less than 10 years ago, many instructors still engage in substantial lecturing (i.e., more than one-third of class time). Relatedly, we find that the majority of RBIS use centers on pedagogies designed to supplement a primarily lecture-based classroom rather than pedagogies designed to support a primarily active learning classroom. This suggests that the physics education research community and beyond has done well promoting knowledge about RBISs and inspiring instructors to try RBISs in their courses. But, there is still room to improve. Based on available evidence about effective instructional practices, we recommend that change agents focus on supporting instructors to increase the percent of class time in active learning and to implement higher impact strategies.

Published by the American Physical Society
2024