bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of IGF-1R in Pediatric Malignancies
Authors: Kim Su Young , Toretsky Jeffrey A. , Scher Daniel , Helman Lee J. 
Published: January 2009

Learning Objectives
Evaluate the components that make up the insulin-like growth factor family. Differentiate between different strategies to modulate IGF-1R. Determine when to utilize the rationale for therapeutic targeting of IGF-1R in childhood malignancies.
This article is available for continuing medical education credit at CME.TheOncologist.com.
Occurrence of cystacanths of Plagiorhynchus cylindraceus (Acanthocephala) in the terrestrial isopods Trachelipus squamuliger and Armadillidium vulgare (Oniscidea) in Bulgaria
Authors: Dimitrova Zlatka 
Published: January 2009

AbstractIn total, 2097 individuals of Trachelipus squamuliger and 20 individuals of Armadillidium vulgare from four habitats (three woodland sites and one pasture) in the region of Stara Zagora, Bulgaria, were examined for the presence of cystacanths of Plagiorhynchus cylindraceus, a common acanthocephalan parasite of passerine birds. In T. squamuliger from woodland habitats, cystacanths were found with prevalence 4.0–9.3%, intensity 1–5 (mean 1.22–1.57) and mean abundance 0.057–0.113. No significant differences were observed between infections in males and females of T. squamuliger. None of the T. squamuliger individuals from the pasture examined was infected. Out of 48 infected females of T. squamuliger, only one had developed eggs (in agreement with previous studies revealing the negative effect of the cystacanths on the development of female gonads of woodlice). One individual of A. vulgare was infected with a single cystacanth. The occurrence of P. cylindraceus in T. squamuliger is a new host record.
A new species of Falcaustra (Nematoda, Kathlaniidae) from Cnemaspis aff. tro pidogaster (Squamata, Gekkonidae) from Sri Lanka
Authors: Bursey Charles , Goldberg Stephen , Bauer A. 
Published: January 2009

AbstractFalcaustra desilvai sp. nov. (Ascaridida, Kathlaniidae) from the large intestine of Cnemaspis aff. tropidogaster (Squamata, Gekkonidae) is described and illustrated. Falcaustra desilvai represents the 4th nematode species from Sri Lanka to be assigned to the genus and is distinguished from other Sri Lankan species by the distribution pattern of caudal papillae (12 precloacal, 2 adcloacal, 10 postcloacal, and 1 median), length of spicules (956–1046 μm) and absence of a pseudosucker.
On Rosa-type labelings and cyclic graph decompositions
Authors: El-Zanati Saad , Eynden Charles 
Published: January 2009

Abstract
A labeling (or valuation) of a graph G is an assignment of integers to the vertices of G subject to certain conditions. A hierarchy of graph labelings was introduced by Rosa in the late 1960s. Rosa showed that certain basic labelings of a graph G with n edges yielded cyclic G-decompositions of K
2n+1 while other stricter labelings yielded cyclic G-decompositions of K
2nx+1 for all natural numbers x. Rosa-type labelings are labelings with applications to cyclic graph decompositions. We survey various Rosa-type labelings and summarize some of the related results.
Large sets of t-designs from groups
Authors: Magliveras Spyros 
Published: January 2009

Abstract
This paper addresses questions related to the existence and construction of large sets of t-(v, k, λ) designs. It contains material from my talk in the Combinatorial Designs Conference in honor of Alex Rosa’s 70th birthday, which took place in beautiful Bratislava, in July, 2007. Naturally, only a small number of “highlight” topics could be included, and for the most part these involve the use of symmetry, that is, it is assumed that the particular designs or large sets of designs, are invariant under a prescribed group of automorphisms. I present almost no proofs, but give references so that the reader can find a much wider repertory of theorems and constructions in the literature. For completeness, I include the statement of a few recursive constructions. The latter are extremely important on their own right, and deserve extensive attention elsewhere. I hope the reader becomes interested in the intriguing open problems posed at the end of the paper and succeeds in solving some of them.
Unique Identification of Supramolecular Structures in Amyloid Fibrils by Solid‐State NMR Spectroscopy
Authors: Nielsen Jakob T. , Bjerring Morten , Jeppesen Martin D. , Pedersen Ronnie O. , Pedersen Jan M. , Hein Kim L. , Vosegaard Thomas , Skrydstrup Troels , Otzen Daniel E. , Nielsen Niels C. 
Published: January 2009

AbstractDie Fibrillenstruktur, die das amyloidogene Fragment SNNFGAILSS des menschlichen Insel‐Amyloid‐Polypeptids (hIAPP) bildet, wurde mit einer Auflösung von 0.52 Å bestimmt. Aus den Festkörper‐NMR‐Spektren einfach erhältliche Symmetrieinformationen (siehe Bild) können zusammen mit langreichweitigen Randbedingungen genutzt werden, um die supramolekulare Organisation von Fibrillen eindeutig zu identifizieren.magnified image
A Selective Fluoroionophore Based on BODIPY‐functionalized Magnetic Silica Nanoparticles: Removal of Pb2+ from Human Blood
Authors: Lee Hye Young , Bae Doo Ri , Park Ji Chan , Song Hyunjoon , Han Won Seok , Jung Jong Hwa 
Published: January 2009

AbstractWeg mit Blei: Der Fluoreszenzrezeptor im Titel zeichnet sich durch eine hohe Affinität und Selektivität für Pb2+ gegenüber konkurrierenden Metallionen in Wasser aus (siehe Bild), wobei der Faktor der gesamten Emissionsänderung am Emissionsmaximum für Pb2+ etwa 8 beträgt. Der Fluoreszenzrezeptor kann 96 % von 100 ppb Pb2+ aus menschlichem Blut entfernen und eignet sich für die effektive, selektive und schnelle Entfernung von Pb2+ in vivo.magnified image
Proton‐Detected Solid‐State NMR Spectroscopy of Natural‐Abundance Peptide and Protein Pharmaceuticals
Authors: Zhou Donghua H. , Shah Gautam , Mullen Charles , Sandoz Dennis , Rienstra Chad M. 
Published: January 2009

AbstractThe natural way: A sensitive NMR spectroscopic method is developed to obtain well‐resolved two‐dimensional spectra (15N–1H and 13C–1H) for natural‐abundance (that is, without the need for isotopic enrichment) large‐molecule samples, such as biopharmaceuticals. This method gives structural insights on two lyophilized aprotinin samples and three insulin samples in lyophilized, microcrystalline suspension formulation (red; see picture) and fibril (green) forms.magnified image
Structural and Electronic Properties of Ultrathin Tin–Phthalocyanine Films on Ag(111) at the Single‐Molecule Level
Authors: Wang Yongfeng , Kröger Jörg , Berndt Richard , Hofer Werner 
Published: January 2009

AbstractHeads or tails? The evolution of structural and electronic properties of tin–phthalocyanine films has been analyzed for sub‐monolayer to multilayer coverage using low‐temperature scanning tunneling microscopy. Two molecular conformations are observed: randomly dispersed for the first layer, and islands with a single conformation in subsequent layers.magnified image
Unique Identification of Supramolecular Structures in Amyloid Fibrils by Solid‐State NMR Spectroscopy
Authors: Nielsen Jakob T. , Bjerring Morten , Jeppesen Martin D. , Pedersen Ronnie O. , Pedersen Jan M. , Hein Kim L. , Vosegaard Thomas , Skrydstrup Troels , Otzen Daniel E. , Nielsen Niels C. 
Published: January 2009

AbstractThe fibril structure formed by the amyloidogenic fragment SNNFGAILSS of the human islet amyloid polypeptide (hIAPP) is determined with 0.52 Å resolution. Symmetry information contained in the easily obtainable resonance assignments from solid‐state NMR spectra (see picture), along with long‐range constraints, can be applied to uniquely identify the supramolecular organization of fibrils.magnified image
A Selective Inhibitor Gal‐PUGNAc of Human Lysosomal β‐Hexosaminidases Modulates Levels of the Ganglioside GM2 in Neuroblastoma Cells
Authors: Stubbs Keith A. , Macauley Matthew S. , Vocadlo David J. 
Published: January 2009

AbstractGal‐PUGNAc (see picture), a highly selective inhibitor for β‐hexosaminidases HEXA and HEXB is cell‐permeable and modulates the activity of HEXA and HEXB in tissue culture, increasing ganglioside GM2 levels. Gal‐PUGNAc should allow the role of these enzymes to be studied at the cellular level without generating a complex chemical phenotype from concomitant inhibition of O‐GlcNAcase.magnified image
A Selective Fluoroionophore Based on BODIPY‐functionalized Magnetic Silica Nanoparticles: Removal of Pb2+ from Human Blood
Authors: Lee Hye Young , Bae Doo Ri , Park Ji Chan , Song Hyunjoon , Han Won Seok , Jung Jong Hwa 
Published: January 2009

AbstractGet the lead out: The title fluorescence receptor exhibits a high affinity and selectivity for Pb2+ over competing metal ions in water (see picture) with an overall emission change of approximately 8‐fold at the emission maximum for Pb2+. The fluorescence receptor can remove 96 % of 100 ppb Pb2+ from human blood, and can be useful and effective for the selective and rapid removal of Pb2+ in vivo.magnified image
Professionelles Management im Verkehrsanlagenbau – Planen und Bauen unter rollendem Rad
Authors: Schönthaler Carmen 
Published: January 2009

AbstractIm Rahmen dieses Beitrages wird das Projekt der Deutschen Bahn AG “Drei Brücken für Besigheim” vorgestellt. Es wird ein Überblick zur Gesamtbaumaßnahme gegeben. Die Bauwerke werden im Einzelnen aus bauwerkstechnischer Sicht betrachtet. Es werden Probleme in der Abwicklung beleuchtet und gefundene Lösungen aufgezeigt.Die Thematik “Bauen unter rollenden Rad” und ein immens hoher Termindruck für die Inbetriebnahme der neuen Bauwerke bildeten dabei einen ganz eigenen komplexen Rahmen im Gesamtprojekt. Um der Komplexität zu begegnen, wurde der Einsatz eines professionellen Projekt‐ und Kommunikationsmanagements erforderlich: Um etwas gemeinsam zu tun, musste kommuniziert werden. Um das zu bewältigen, strebte man nach Exzellenz im Sinne des Total Quality Managements. Das Zusammenspiel aller Beteiligten trat in den Fokus. Als Lösungsansatz für einen hohen Zielerreichungsgrad diente eine effiziente und effektive Kommunikation. Erst die daraus resultierenden Synergieeffekte garantierten eine positive Umsetzung der Aufgabenstellung und führten zu einem qualitativ gelungenen Ergebnis (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Multinuclear Non‐Heme Iron Complexes for Double‐Strand DNA Cleavage
Authors: Megens Rik P. , van den Berg Tieme A. , de Bruijn A. Dowine , Feringa Ben L. , Roelfes Gerard 
Published: January 2009

AbstractBleomycin mimics: Efficient oxidative double‐strand DNA cleavage has been achieved with multinuclear non‐heme iron complexes (see scheme). These complexes therefore represent model compounds that mimic the mode of action of the anti‐tumor drug bleomycin.magnified imageThe cytotoxicity of the anti‐tumor drug BLM is believed to be related to the ability of the corresponding iron complex (Fe‐BLM) to engage in oxidative double‐strand DNA cleavage. The iron complex of the ligand N4Py (Fe‐N4Py; N4Py=N,N‐bis(2‐pyridyl)‐N‐bis(2‐pyridyl)methylamine) has proven to be a particularly valuable spectroscopic and functional model for Fe‐BLM. It is also a very active oxidative DNA‐cleaving agent. However, like all other synthetic Fe‐BLM mimics, it gives only single‐strand DNA cleavage. Since double‐strand DNA cleavage requires the delivery of two oxidizing equivalents to the DNA, it was envisaged that multinuclear iron complexes might be capable of effecting double‐strand cleavage. For this purpose, a series of ditopic and tritopic N4Py‐derived ligands has been synthesized and the corresponding iron complexes have been evaluated for their efficacy in the oxidative cleavage of supercoiled pUC18 plasmid DNA. The dinuclear iron complexes showed significantly enhanced double‐strand cleavage activity compared to mononuclear Fe‐N4Py, which was relatively independent of the structure of the linking moiety. Covalent attachment of a 9‐aminoacridine intercalator to a dinuclear complex did not give rise to improved double‐strand DNA cleavage. The most efficient oxidative double‐strand cleavage agents proved to be the trinuclear iron complexes. This is presumably the result of increased probability of the simultaneous delivery of two oxidizing equivalents to the DNA.
Do We Understand the Recyclability of Ionic Liquids?
Authors: Wu Bo , Liu WeiWei , Zhang YuMei , Wang HuaPing 
Published: January 2009

AbstractRecycling of “green” solvents: Recycling of ionic liquids with high efficiency is of key importance on going from the laboratory‐scale to large‐scale industrial application of these solvents.magnified imageRecyclability is one of the reasons why ionic liquids (ILs) are attracting the attention of a growing number of scientists and engineers, but do we understand the recyclability of ILs in a real sense? For this purpose, this review focuses on the methods need for their separation from their “working” environment. Here we proposed that the appropriate separation method should be selected according to different systems. To better understand the separation of ILs, fundamental research on the existence forms (ions, ion pairs or supermolecule) of ILs in solvents is vitally important.
Gated and Differently Functionalized (New) Porous Capsules Direct Encapsulates' Structures: Higher and Lower Density Water
Authors: Mitra Tamoghna , Miró Pere , Tomsa Adrian‐Raul , Merca Alice , Bögge Hartmut , Ávalos Josep Bonet , Poblet Josep Maria , Bo Carles , Müller Achim 
Published: January 2009

AbstractEither more or less neighbors favored? By deliberate choice of the internal ligands of the porous nanocapsules [{(Mo)Mo5}12{Mo2(ligand)}30]n−, the respective cavities can be differently sized/functionalized. This allows one to trap, in two different corresponding capsules, 100 water molecules arranged in shells that exhibit more and less dense packing, respectively—the latter type in a capsule with smaller internal ligands; the picture shows the related 100 O atoms at the vertices of the four polyhedra, while two dodecahedra (shown in pale green and red) have only 10 H2O molecules instead of 20.magnified imageBy the deliberate choice of the internal ligands of the porous nanocapsules [{(Mo)Mo5}12{Mo2(ligand)}30]n−, the respective cavities' shells can be differently sized/functionalized. This allows one to trap the same large number of water molecules, that is, 100 in a capsule cavity with formate ligands having a larger space available, as well as in a cavity containing sulfates and hypophosphites, that is, with less space. Whereas the 100 molecules fill the space completely in the second case in which they are organized in three shells, a four‐shell system with underoccupation and broken hydrogen bonds is observed in the other case. This is an unprecedented result in terms of the structurally well defined special forms of “higher and lower density” water molecule assemblies. Precisely, by replacing the larger ligands in the mentioned nanocapsule type by formates, voids in the capsule cavity of (HC(NH2)2)22[{(HC(NH2)2)20+(H2O)100}⊂{(Mo)Mo5O21(H2O)6}12{Mo2O4(HCO2)}30]⋅ca. 200 H2O are generated that get filled with water molecules concomitant with an expansion of the three to four shell {H2O}100 cluster. The water shells in both capsules containing different ligands are organized in the form of dodecahedra (partly with underoccupation) and a strongly distorted rhombicosidodecahedron spanned by a {H2O}60={(H2O)5}12 aggregate. The well‐defined water shells only emerge if cations cannot enter into the capsules, which is achieved by closing the pores with plugs/guests such as formamidinium cations. The work is based on the syntheses of two new compounds, related single‐crystal X‐ray diffraction studies, and molecular dynamics simulations, which show remarkably that water molecule shell structuring occurs in the capsules due to the confined conditions even in the case of open pores and at room temperature if cation uptake is prevented.
Equilibrium and Kinetic Properties of the Lanthanoids(III) and Various Divalent Metal Complexes of the Heptadentate Ligand AAZTA
Authors: Baranyai Zsolt , Uggeri Fulvio , Giovenzana Giovanni B. , Bényei Attila , Brücher Ernő , Aime Silvio 
Published: January 2009

AbstractTowards improved kinetic stability: A detailed account of the complexation properties of the ligand 1,4‐bis(hydroxycarbonylmethyl)‐6‐[bis(hydroxycarbonylmethyl)]amino‐6‐methylperhydro‐1,4‐diazepine (AAZTA; see figure) is reported. Its Gd3+ complex shows a kinetic stability superior to that of complexes formed by higher denticity ligands and opens the way for a new reference structure for MRI contrast agents.magnified imageThe heptadentate ligand 1,4‐bis(hydroxycarbonylmethyl)‐6‐[bis(hydroxycarbonylmethyl)]amino‐6‐methylperhydro‐1,4‐diazepine (AAZTA) and its derivatives were recently reported to give stable complexes with Gd3+ with superior efficiency as MRI contrast agents. Nevertheless, only preliminary data are available on the coordination behavior of this interesting ligand. In this work, thermodynamic and kinetic stability data are determined for the formation of complexes with AAZTA and the lanthanoid metal ions, and other divalent metal ions of interest for this application. The AAZTA ligand binds the lanthanoid ions with log KML values of 17.53–21.85 with its affinity steadily increasing from La3+ to Lu3+, suggesting that the seven‐membered skeleton is better suited to accommodate smaller metal ions. Even though the denticity is lower, the stability of the heavier lanthanoid complexes is comparable to those of the classical ligand diethylenetriaminepentaacetic acid (DTPA). The transmetalation reactions of [Gd(AAZTA)]− with Cu2+ and Eu3+ predominantly occur through proton‐assisted dissociation of the complex. The role of the direct attack of Cu2+ or Eu3+ in the exchange reactions is limited, although the formation of dinuclear complexes decreases the proton‐assisted dissociation. Near physiological conditions, [Gd(AAZTA)]− is significantly more inert than [Gd(DTPA)]2−, allowing its potentially safe use as contrast agent in magnetic resonance imaging.
In vivo analysis of MT‐based vesicle transport by confocal reflection microscopy
Authors: Gáspár Imre , Szabad János 
Published: January 2009

AbstractThe use of confocal reflection microscopy (CRM) for the in vivo analysis of microtubule (MT) mediated transport of lipid droplets in the developing Drosophila egg primordia is described here. The developing Drosophila oocytes are ideal objects to study MT‐mediated transport in vivo: transport of e.g. the lipid droplets can be conveniently, selectively and sensitively monitored through CRM and the egg primordia are readily available for physical, chemical and/or genetic manipulations. CRM is a non‐destructive way to follow vesicle movement and allows high frame rate image recording. When combined with fluorescence imaging, CRM offers simultaneous visualization of the cargo and the protein(s) of interest, i.e. a motor or a cargo adapter, thus allowing a better understanding of MT‐mediated transport and spatiotemporal coordination of the transport machinery. Cell Motil. Cytoskeleton 2009. © 2009 Wiley‐Liss, Inc.
Pancreatic neuroendocrine tumors
Authors: Hill Joshua S. , McPhee James T. , McDade Theodore P. , Zhou Zheng , Sullivan Mary E. , Whalen Giles F. , Tseng Jennifer F. 
Published: January 2009

AbstractBACKGROUND:Although surgical resection is generally recommended for patients with localized pancreatic neuroendocrine tumors (PNETs), the impact of resection on overall survival is unknown. The authors investigated the survival advantage of pancreatic resection using a national database.METHODS:This is a retrospective survival analysis of patients with PNETs from the Surveillance, Epidemiology, and End Results database (1988‐2002).RESULTS:A total of 728 patients with PNETs were identified with a median survival of 43 months using Kaplan‐Meier survival methods. Resection of tumor was associated with significantly improved survival compared with those patients who were recommended for but did not undergo resection (114 months vs 35 months; P < .0001). This survival benefit was demonstrated for patients with localized, regional, and metastatic disease. A multivariable Cox proportional hazards model was constructed to assess the overall effect of surgical resection on survival, and demonstrated an adjusted odds ratio of 0.48 (95% confidence interval, 0.35‐0.66) compared with those who were recommended for surgery but did not proceed to surgery.CONCLUSIONS:The authors have demonstrated in a large national study that resection of primary tumor in patients with PNETs is associated with improved survival across all disease stages. Patients with localized, regional, and metastatic PNETs who are reasonable operative candidates should be considered for resection of their primary tumors. Cancer 2009. © 2009 American Cancer Society.
Racial disparities in the development of breast cancer metastases among older women
Authors: Schootman Mario , Jeffe Donna B. , Gillanders William E. , Aft Rebecca 
Published: January 2009

AbstractBACKGROUND:Distant metastases are the most common and lethal type of breast cancer relapse. The authors examined whether older African American breast cancer survivors were more likely to develop metastases compared with older white women. They also examined the extent to which 6 pathways explained racial disparities in the development of metastases.METHODS:The authors used 1992‐1999 Surveillance, Epidemiology, and End Results (SEER) data with 1991‐1999 Medicare data. They used Medicare's International Classification of Diseases, Ninth Revision, Clinical Modification codes to identify metastases of respiratory and digestive systems, brain, bone, or other unspecified sites. The 6 pathways consisted of patient characteristics, tumor characteristics, type of treatment received, access to medical care, surveillance mammography use, and area‐level characteristics (poverty rate and percentage African American) and were obtained from the SEER or Medicare data.RESULTS:Of the 35,937 women, 10.5% developed metastases. In univariate analysis, African American women were 1.61 times (95% confidence interval [CI], 1.54‐1.83) more likely to develop metastasis than white women. In multivariate analysis, tumor grade, stage at diagnosis, and census‐tract percentage African American explained why African American women were more likely to develop metastases than white women (hazard ratio, 0.84; 95% CI, 0.68‐1.03).CONCLUSIONS:Interventions to reduce late‐stage breast cancer among African Americans also may reduce racial disparities in subsequent increased risk of developing metastasis. African Americans diagnosed with high‐grade breast cancer could be targeted to reduce their risk of metastasis. Future studies should identify specific reasons why the racial distribution in census tracts was associated with racial disparities in the risk of breast cancer metastases. Cancer 2009. © 2009 American Cancer Society.