bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Next Generation of Phosphorus Bisylide Superbases – Synthesis, Structures, Basicity and Proton Self‐Exchange
Authors: Kögel Julius F. , Ullrich Sebastian , Xie Xiulan , Finger Lars H. , Kovačević Borislav , Saame Jaan , Haljasorg Tõiv , Leito Ivo , Sundermeyer Jörg 
Published: February 2025

AbstractHerein we present two phosphorus ylide superbases to enhance the basicity of 1,8‐bis (methylylidene (hexamethyltriamino) phosphorane) naphthalene (MHPN) – the first superbase with interacting carbon atoms as basicity centers. Its 1‐pyrrolidinyl substituted analog 1,8‐bis (methylylidene (tris (1‐pyrrolidinyl)) phosphorane) naphthalene (MTPN) and MHPN's theoretically predicted higher homologue P2‐MHPN exhibit extreme pKaH values of 26.0 and 29.5 (experimental) in THF solution and 33.6 and 37.4 (estimated) in acetonitrile solution. The corresponding calculated gas phase basicity values are 281.4 and 284.6 kcal mol−1, respectively. We prepared the neutral free bases together with the corresponding mono‐ and bisprotonated species which were characterized by NMR spectroscopy, ESI mass spectrometry, IR spectroscopy, elemental analysis and partly XRD analysis. The monoprotonated forms exhibit a rapid proton self‐exchange between the two carbon atoms in peri‐position and dynamic NMR spectroscopic methods revealed self‐exchange rates of 2298 s−1 and 300 s−1 at 300 K for MTPN and P2‐MHPN, respectively. However, computational studies reveal that the proton chelating effect, which typically considerably contributes to the basicity of proton sponges with basicity centers on nitrogen, is negligible in bisylides, as the 1,8‐substitution pattern yields almost the same basicity as the corresponding 2,7‐ or 1,5‐substituted analogues.
Results of Cancer and Leukemia Group B 10102 (Alliance), a Phase 1/2 Study
Authors: Luskin Marlise R. , Yin Jun , Lozanski Gerard , Curran Emily , Malnassy Gregory , Mrózek Krzysztof , Bloomfield Clara D. , Cataland Spero R. , Fulton Noreen , Kolitz Jonathan , Laplant Betsy , Kour Oudom , Powell Bayard L. , Vij Ravi , Wang Eunice S. , Grinblatt David , Stone Richard M. , Uy Geoffrey L. , Larson Richard A. , Stock Wendy 
Published: February 2025

AbstractBackgroundAcute lymphoblastic leukemia (ALL) in adults is aggressive, with long‐term outcomes impacted by treatment resistance and toxicity. CD52 is expressed in most cases of B‐ and T‐lineage ALL. Alemtuzumab, a humanized immunoglobulin G1 monoclonal antibody that targets CD52, was identified as a potential agent to improve treatment efficacy without increasing toxicity.MethodsIn this phase 1/2 study (Cancer and Leukemia Group B [CALGB] 10102, NCT00061945), a course of single‐agent alemtuzumab was intercalated into CALGB 19802 backbone chemotherapy after the third course of intensive chemotherapy in those who were CD52+ at diagnosis. Phase 1 tested three dose levels of subcutaneous alemtuzumab (10, 20, and 30 mg 3 times weekly for 4 weeks/12 doses) and demonstrated that 30 mg was tolerable. Phase 2 established feasibility.ResultsThe study enrolled 295 evaluable patients (115 in phase 1, 180 in phase 2); 206 (69.8%) were CD52+. Among evaluable CD52+ patients, 43.7% (90/206) completed the first three treatment modules; 97.8% (88 of 90) were treated with alemtuzumab. Alemtuzumab was associated with cytomegalovirus viremia, which occurred in 23.3% (14 of 60) of patients during and 29.2% (19 of 65) after alemtuzumab treatment. With a median follow‐up of 101.2 months, median overall survival (OS) was 26.3 months (3‐year rate, 44%; 5‐year rate, 36%; 10‐year rate, 31%). Landmark analysis at the start of the fourth course of treatment demonstrated no difference in OS or disease‐free survival between patients who did and who did not receive alemtuzumab.ConclusionAlemtuzumab was feasible to administer in adults with ALL receiving intensive chemotherapy, but was without evidence of benefit.
Advances in CO2 assisted oxidative dehydrogenation of light alkanes to light alkenes
Authors: Zhang Siran , Wu Chongchong , Xin Jing , Yang Guoming , Li Yongheng , Su Mengjun , Zhang Haihong , Zhang Huiling , Wang Lianying 
Published: February 2025

The CO2‐assisted oxidative dehydrogenation of light alkanes offers a promising route for converting underutilized resources into valuable chemical feedstocks while addressing environmental challenges associated with CO2 emissions. CO2 plays a dual role in ODH by acting as a mild oxidant that enhances product selectivity and catalyst stability while preventing carbon deposition through RWGS and Boudouard reactions. The review has elucidated a variety of catalyst design and optimization strategies that may guide the future development of novel CO2‐assisted ODH catalysts with improved alkane conversion, superior alkene selectivity, and long‐term stability. It provides a comprehensive analysis of the structural characteristics, catalytic performances, and reaction mechanisms of typical catalysts. Special attention is given to the structure‐performance relationship of these catalysts, emphasizing how changes in promoters, supports, and morphology affect critical properties such as redox behavior, acidity‐basicity balance, dispersion of active components, and catalyst‐support interactions. Finally, future research directions and perspectives for the CO2‐assisted ODH of ethane and propane are proposed, with a focus on advancing catalyst design and optimization strategies. This review aims to serve as a comprehensive reference for researchers exploring the potential of CO2‐assisted ODH in promoting sustainable production of light alkenes.
Associations Between Transdiagnostic Psychological Processes and Global Symptom Severity Among Outpatients With Various Mental Disorders: A Cross‐Sectional Study
Authors: Frei Anna Katharina , Studnitz Thomas , Seiffer Britta , Welkerling Jana , Zeibig Johanna‐Marie , Herzog Eva , Günak Mia Maria , Ehring Thomas , Takano Keisuke , Nakagawa Tristan , Sundmacher Leonie , Himmler Sebastian , Peters Stefan , Flagmeier Anna Lena , Zwanzleitner Lena , Ramos‐Murguialday Ander , Wolf Sebastian 
Published: February 2025

ABSTRACTObjectiveKnowledge about transdiagnostic factors associated with global symptom severity among patients diagnosed with various mental disorders remains limited. This study examined the cross‐sectional associations between transdiagnostic processes including global emotion regulation and specific emotion regulation strategies (i.e., amount of physical activity and sedentary behaviour, repetitive negative thinking and sleep routines) with global symptom severity, while controlling for sociodemographic data (age, gender, employment status, relationship status, and educational level) and fear of the coronavirus.MethodsData from 401 outpatients, aged 42.08 years on average (SD = 13.26; 71.3% female), diagnosed with depressive disorders, non‐organic primary insomnia, agoraphobia, panic disorder and/or post‐traumatic stress disorder were examined. This study is a secondary analysis of a randomized controlled trial. Data were collected from 10 different study sites between March 2021 and May 2022 for cross‐sectional analysis. The influence of predictors of global symptom severity was determined using three‐step hierarchical multiple regression: (1) control variables, (2) global emotion regulation and (3) specific emotion regulation strategies. Global symptom severity was measured using the Global Severity Index, derived from the Brief Symptom Inventory‐18. Predictors were measured using validated scales, and physical activity was additionally assessed via accelerometer‐based sensors.ResultsIn the first step, control variables accounted for 4% of variance in global symptom severity. The inclusion of global emotion regulation in the second step explained 26% of the outcome variance, and the incorporation of specific emotion regulation strategies in the third step increased the explained variance to 37%. Significant predictors included global emotion regulation (β = 0.28), repetitive negative thinking (β = 0.26) and sleep routines (β = 0.25).ConclusionGlobal emotion regulation along with repetitive negative thinking and sleep routines as specific emotion regulation strategies are identified as transdiagnostic psychological processes that may serve as treatment targets for evidence‐based interventions designed to enhance emotion regulation, particularly in transdiagnostic samples of stress‐related disorders. Additional prospective longitudinal studies with transdiagnostic samples are necessary to explore possible causal relationships.
Mutation of Ehd1 prolongs basic vegetative growth periods to boost biomass and grain yield in rice
Authors: Wang Limin , Zhu Jiahui , Liu Jiaoyan , Zhan Jiatao , Li Yuechen , Wang Ru , Tang Huiwu 
Published: February 2025

AbstractHeading date is a pivotal agronomic trait that influences grain yield, and it is determined by florigen genes. However, the regulation of heading date and its impact on other agronomic traits remain to be fully understood. In this study, we identified a mutant named late‐flowering and big panicle 1 (lbp1) in rice; we surveyed the growth and yield traits in lbp1. Changes in gene expression between lbp1 and wild type (WT) were determined by RNA‐seq. lbp1 exhibits delayed heading of 1 month and enhancements in various agronomic traits. Compared with WT plants, lbp1 showed 336.9% higher biomass production, 27.7% longer panicle length, 41.2% higher grain numbers, 29.4% and 56.6% more primary and secondary branch numbers, and an overall 58.7% higher grain yield. Map‐based cloning pinpointed that the mutant phenotypes stemmed from a mutation in the early heading date 1 (Ehd1) gene. Through RNA‐seq and quantitative reverse transcription‐polymerase chain reaction analysis, we observed significantly lower expression levels of heading date 3a (Hd3a) and RICE FLOWERING LOCUS T 1 (RFT1) in lbp1 compared to WT plants. Additionally, the expression levels of several MADS‐box genes were downregulated in the mutant. Our findings indicate that negative regulation of the Ehd1‐Hd3a/RFT1 pathway leads to delayed heading, enhanced biomass production, and increased grain yield. This discovery presents an effective breeding strategy for developing new japonica rice varieties with prolonged vegetative growth periods suitable for cultivation in southern China and other low‐latitude regions.
RNF31 induces paclitaxel resistance by sustaining ALYREF cytoplasmic–nuclear shuttling in human triple‐negative breast cancer
Authors: Huang Shumei , Shi Dongni , Dai Shuqin , Jiang Xingyu , Wang Rui , Yang Muwen , Chen Boyu , Chen Xuwei , Kong Lingzhi , He Lixin , Deng Pinwei , Chen Xiangfu , Lin Chuyong , Li Yue , Li Jun , Song Libing , Shi Yawei , Wei Weidong 
Published: February 2025

AbstractBackgroundResistance to paclitaxel‐based chemotherapy is the major obstacle in triple‐negative breast cancer (TNBC) treatment. However, overcoming paclitaxel resistance remains an unsolved problem. The present study aimed to determine whether paclitaxel treatment impairs Aly/REF export factor (ALYREF) cytoplasmic–nuclear shuttling, its mechanism, and the role of ubiquitinated ALYREF in paclitaxel resistance.MethodsThe subcellular proportion of ALYREF was detected in samples from patients with TNBC using immunohistochemistry to analyze the relationship between ALYREF distribution and paclitaxel response. Cell viability assays, immunofluorescence assays, quantitative real‐time reverse transcription PCR assays, western blotting, and terminal deoxynucleotidyl transferase nick‐end‐labelling assays were conducted to measure the biological function of the subcellular proportion of ALYREF and E3 ligase ring finger protein 31 (RNF31) on paclitaxel sensitivity in TNBC. The synergistic effects of an RNF31 inhibitor plus paclitaxel on TNBC were evaluated. Cox regression models were adopted to assess the prognostic role of RNF31 in TNBC.ResultsHerein, we showed that regulation of ALYREF cytoplasmic–nuclear shuttling is associated with the paclitaxel response in TNBC. In paclitaxel‐sensitive TNBC, ALYREF was trapped in the cytoplasm by paclitaxel, while in paclitaxel‐resistant TNBC, ALYREF was efficiently transported into the nucleus to exert its function, allowing the export of the mRNAs encoding paclitaxel‐resistance‐related factors, including tubulin beta 3 class III (TUBB3), stathmin 1 (STMN1), and microtubule‐associated protein Tau (TAU), ultimately inducing paclitaxel resistance in TNBC. Mechanistically, we found that RNF31 interacts with and ubiquitinates ALYREF, which facilitates ALYREF nuclear transportation via importin 13 (IPO13) under paclitaxel treatment. Notably, the RNF31 inhibitor and paclitaxel synergistically repressed tumour growth in vivo and in TNBC patient‐derived organoids. In addition, analysis of patients with TNBC showed that elevated RNF31 levels correlated with poor prognosis.ConclusionThese data indicated that RNF31‐mediated ALYREF ubiquitylation could represent a potent target to reverse paclitaxel resistance in TNBC.Key points
RNF31 facilitated ALYREF‐mediated PTX resistance in TNBC.
RNF31 promoted ALYREF nuclear transport via IPO13 in response to PTX treatment, subsequently enhancing the export of mRNAs encoding PTX resistance‐related factors, including TUBB3, STMN1, and TAU.
Blocking RNF31 trapped ALYREF in the cytoplasm and induced TNBC cell death upon PTX treatment.
Inhibiting RNF31 activity re‐sensitized PTX‐resistant TNBC to PTX treatment.
Synthesis of a New Cobalt(II) Complex Compound Containing 2,2′‐Bipyridyl Ligand and Its Catalytic Properties in the Formation of CO2‐Sorbing Oligomers
Authors: Pawlak Marta , Drzeżdżon Joanna , Gołąbiewska Anna , Jarzembska Katarzyna N. , Kamiński Radosław , Pospieszny Tomasz , Datta Janusz , Jacewicz Dagmara 
Published: February 2025

AbstractAs an element, cobalt has a very interesting coordination chemistry and great potential to participate in the formation of a variety of complex compounds, that play a significant role in the synthesis of catalytic systems. In the present work, a new cobalt(II) complex compound with an unusual and rare structure, not previously described in the literature, was synthesized. This complex has two 2,2′‐bipyridyl ligands, a water molecule and, most interestingly, a sulfate(VI) anion in the Co(II) coordination sphere. Its use and catalytic properties were studied in the oligomerization of selected olefins, where it acted as a precatalyst. The achieved catalytic activity values were rather high (<100 g mmol−1 h−1 ⋅ bar−1), except for the oligomerization process of 2,3‐dibromo‐2‐propen‐1‐ol using MAO. The obtained oligomers were subjected to structural (FT‐IR, SEM, MALDI‐TOF‐MS) and thermal (TG, DSC) analysis, and the results allowed to characterize their physicochemical properties. The conducted process allowed to determine the effect of the applied activator on the catalytic activity, as well as the structural and thermal properties of the obtained oligomers. In addition, the specific surface area and sorption properties of the oligomerization products were studied, and one of them showed very high CO2 sorption values (<1.6 mmol g−1).
Effect of Wall, Roof, and Window‐to‐Wall Ratio on the Cooling and Heating Load of a Building in India
Authors: Ahmad Asim , Prakash Om , Brar L. S. , Irshad Kashif , Hasnain S. M. Mozammil , Paramasivam Prabhu , Ayanie Abinet Gosaye 
Published: February 2025

ABSTRACTThis study examines the impact of various combinations of walls, roofs, and window‐to‐wall ratios (WWRs) on the cooling and heating loads of residential buildings in India's composite climatic zone. Utilizing EnergyPlus and eQuest simulations, the thermal performance of three building types is analyzed across 32 cases involving two types of walls (W1, W2), roofs (R1, R2), and WWRs of 10%, 20%, 30%, and 40%. The results indicate that Case 29 (W2 R2 N2 WWR1), characterized by a north‐facing orientation, square‐shaped design, and a 10% WWR, achieves the lowest cooling and heating loads among all configurations. Specifically, in Building 1, this configuration reduces cooling loads by 26.0% (from 204 to 151 kBTU/h) and heating loads by 28.6% (from 224 to 160 kBTU/h) compared to the highest load scenario, Case 4 (W1 R1 N1 WWR4, west‐facing orientation, square‐shaped design, and 40% WWR). Similar trends are observed for Buildings 2 and 3. These findings underscore the critical role of optimizing building envelope parameters, particularly orientation, shape, and WWR, in achieving significant energy savings. The insights provided by this study can aid architects, engineers, and policymakers in designing energy‐efficient residential buildings.
Analysis of the Evolution Law of Mining‐Induced Water Flowing Fracture of Composite Hard Roof in the Border Mining Area of Inner Mongolia and Shaanxi
Authors: Xiao Jiang , Wang Yihui , Zhang Boyuan , Wang Tongxiaoyu , Liu Yujiang , Wang Yulin , Sun Yachao 
Published: February 2025

ABSTRACTThe mining area along the border of Inner Mongolia and Shaanxi generally contains two thick layers of confined aquifer sandstone, which form a composite hard roof. This constitutes the main hidden risk affecting the safe production of coal seams in this region.The composite hard roof is formed by two layers of thick confined water‐bearing sandstone in the border mining area of Inner Mongolia and Shaanxi and is the main hidden danger affecting the safe production of coal seams. To clarify the evolution law of mining‐induced water‐conducting fractures under such occurrence conditions and prevent roof water damage, this paper comprehensively uses laboratory tests, theoretical analysis and UDEC numerical simulation methods to study the fracture characteristics and migration laws of high and low thick sandstones. The instability conditions of confined water‐bearing sandstones in different layers are analyzed, the distribution law of water‐conducting fractures is expounded, and the evolution characteristics of fractures are further quantitatively described by fractal theory. The results show that the overburden rock transport in the quarry is controlled by the composite rock beams, and the high rock beams will form a “masonry beam” structure, while the low rock beams will form a “step” structure under the influence of secondary displacement and rotation; the superposition of the initial breakage of the composite rock beam and the cycle breakage forms the “pulse” water influx characteristic and the “slow increase—sudden increase—stable” fissure development law; the change of the number of fractures is closely related to the transportation of the composite rock beams, which is divided into three stages of “slow growth‐accelerated growth‐periodic increase.” The fractal dimension quantitative cloud diagram further characterizes that the overall development pattern of water‐conducting fissures remains unchanged under the influence of mining, and the main water‐conducting channels are the fall zone and the vertical breakage fissure zones on both sides. The research results of this paper will provide a scientific basis for water control work in the working face under similar stratigraphic conditions.
Impacts of Swachh Bharat Mission on Health and Communicable Disease Control: A Systematic Review Protocol
Authors: Varshney Karan , Khatri Chirag , Lamichhane Prabhat 
Published: February 2025

ABSTRACTBackground and AimsSwachh Bharat Mission (SBM) is a major initiative led by the Government of Bharat (India) in 2014 to improve sanitation across the country. While the government has received international praise for SBM's achievements, the health impacts of this initiative are not well understood, and to date, no systematic review has been conducted on the topic. In this protocol, we aim to describe our methodology for systematically reviewing the literature to determine the impacts of SBM on communicable disease control and population health outcomes across Bharat.MethodsThis protocol describes the process that will be taken for our systematic review. The review will follow the Preferred Reporting Items for Systematic review and Meta‐Analysis guidelines. Searches will be conducted in Scopus, Embase, Medline, Web of Science, Cumulated Index to Nursing and Allied Health Literature, PubMed, and Global Health. Original, full‐text research articles conducted after October 2014 (the enactment of SBM) will be eligible for inclusion, as will be gray literature. Modeling studies will be excluded from this review. Studies which analyze impacts/trends relating to health or communicable disease control in any region of Bharat will be eligible for inclusion Included studies will assess at least one of the following: impact on infectious disease incidence/prevalence and morbidity/mortality, infant and under‐five mortality, nutritional impacts (including stunting, underweight and wasting) or non‐communicable disease rates. Study quality will be assessed using the Kmet checklist. Where possible, data will be pooled and synthesized to determine overall findings and trends.DiscussionThis review will highlight the extent to which SBM has, or has not, had lasting impacts on health and communicable disease control. The findings of this review can have important implications in shaping and guiding the ongoing implementation of SBM across Bharat.
Longitudinal Relationships of Phubbing, Depression, and Anxiety in the Middle and High School Students: A Cross‐Lagged Panel Network Analysis
Authors: Gao Tingting , Chen Yan , Gai Qian , Su Yingying , Meng Xiangfei 
Published: February 2025

ABSTRACTIntroductionPrior research has documented the associations among phubbing, depression, and anxiety, while the cross‐sectional design failed to clarify the temporal directionality of the relationships between these mental disorders and behavioral issues. To bridge this gap, the present study utilizing longitudinal data aimed to articulate the temporal relationships between these mental disorders and behavioral issues.MethodsA total of 3296 adolescents from China (54.5% girls; Mage = 15.17) participated in the study. Symptoms of phubbing, depression, and anxiety were assessed 18 months later (May 2023) after the baseline (November, 2021). The cross‐sectional network and cross‐lagged panel network models were conducted to explore the associations between the network structures of phubbing, depression, and anxiety. The network comparison test (NCT) was then performed to unveil whether the network structures vary based on school grade.ResultsIn the cross‐sectional network, significant differences in the overall structures between middle and high school students were observed. For the longitudinal network, the core symptoms responsible for temporal relationships were mostly between depressive and anxiety symptoms. Phubbing‐related symptoms and restlessness (anxiety symptom) were the bridge symptoms of phubbing, depression, and anxiety. Besides, the central bridges associated with phubbing‐related symptoms differed significantly across different school stages.ConclusionsSuccessfully regulating negative emotions can play a pivotal role in tackling the root causes linked to phubbing. Apart from addressing restlessness, future interventions focusing on nomophobia and interpersonal conflict in middle school students, as well as self‐isolation in high school students, contributed to mitigating phubbing, depression, and anxiety.