bluuebunny/crossref_metadata_2025_split huggingface dataset:
Opposing effects of fibrosarcoma cell‐derived IL‐1α and IL‐1β on immune response induction
Authors: Marhaba Rachid , Nazarenko Irina , Knöfler Daniela , Reich Eli , Voronov Elena , Vitacolonna Mario , Hildebrand Dagmar , Elter Elena , Apte Ron N. , Zöller Margot 
Published: April 2008

AbstractThere is evidence that cell‐associated IL‐1α supports immune response induction. Here we explored the impact of malignant cell‐derived IL‐1 on immunogenicity, immune response induction and tumor‐induced immunosuppression using 3‐methylcholanthrene‐induced fibrosarcoma lines derived from wild‐type (wt), IL‐1α‐, IL‐1β‐ or IL‐1aβ‐knockout (IL‐1α−/−, IL‐1β−/−, IL‐1αβ−/−) C57BL6 mice. The wt, IL‐1α−/−, IL‐1β−/− and IL‐1αβ−/− fibrosarcoma lines express MHC class I molecules at a high level. The lines do not differ in their susceptibility toward NK cells, macrophages, and allogeneic CTL, or in their capacity as stimulators of an allogeneic response. However, IL‐1β−/− tumors rarely grow in the syngeneic host, which is the consequence of a strong T helper and CTL response induction by IL‐1α‐competent, IL‐1β−/− tumors. On the other hand, IL‐1β‐competent, IL‐1α−/− tumors strongly assist CD11b+Gr‐1+ myeloid‐derived suppressor cell and regulatory T cell expansion, which both suppress with high efficacy activated T helper cell proliferation and CTL lysis. In IL‐1αβ−/− tumors, the absence of IL‐1α becomes decisive, i.e. despite reduced suppressor cell recruitment, tumor growth was unimpaired due to inefficient immune response induction. Thus, sarcoma cell‐derived IL‐1α and IL‐1β do not act in concert. Induction of a strong immune response by IL‐1α demands therapeutic exploitation, which may become more efficient if systemic induction of immunosuppression by IL‐1β can also be circumvented. © 2008 Wiley‐Liss, Inc.
Degradation of HPV20E6 by p53: ΔNp63α and mutant p53R248W protect the wild type p53 mediated caspase‐degradation
Authors: Fei Jian‐Wei , de Villiers Ethel‐Michele 
Published: April 2008

AbstractThe E6 and E7 proteins of human papillomaviruses (HPV) play a crucial role in the pathogenesis of malignant tumors. E6 protein of high‐risk mucosal papillomaviruses targets a number of proteins for proteosomal degradation through complex formation with ubiquitin ligase E6AP. These proteins include, amongst others, p53, paxillin and PDZ‐domain proteins e.g. Dlg and MAGUK. The mechanism by which the E6 protein of cutaneous HPV types interacts with cellular proteins to induce either benign or malignant cutaneous lesions, has not been elucidated, although extensive ultraviolet exposure and mutated p53 (hot‐spot mutations) are known to be associated with non‐melanoma skin cancer. We demonstrate two mechanisms in which HPV20E6 may be involved in the infected cell. One pathway is the wtp53 mediated degradation of HPV20E6 through caspase‐3. Mutated p53R248W and ΔNp63α, as well as other unknown proteins involved in proteosome‐dependent degradation, convey a protective effect on HPV20E6 under these conditions. This unveils a remarkable opposite regulation to the well‐known mechanism of E6‐E6AP mediated degradation of p53 for mucosal HPV types. In a second interaction, ectopically expressed HPV20E6 induces cleavage of procaspase‐3 to active caspase‐3. We demonstrate, in addition, in vivo binding of HPV20E6 to the intermediate filament vimentin. © 2008 Wiley‐Liss, Inc.
Face modeling and editing with statistical local feature control models
Authors: Zhang Yu , Badler Norman I. 
Published: April 2008

AbstractThis article presents a novel method based on statistical facial feature control models for generating realistic controllable face models. The local feature control models are constructed based on the exemplar 3D face scans. We use a three‐step model fitting approach for the 3D registration problem. Once we have a common surface representation for examples, we form feature shape spaces by applying a principal component analysis (PCA) to the data sets of facial feature shapes. We compute a set of anthropometric measurements to parameterize the exemplar shapes of each facial feature in a measurement space. Using PCA coefficients as a compact shape representation, we approach the shape synthesis problem by forming scattered data interpolation functions that are devoted to the generation of desired shape by taking the anthropometric parameters as input. The correspondence among all exemplar face textures is obtained by parameterizing a 3D generic mesh over a 2D image domain. The new feature texture with desired attributes is synthesized by interpolating the exemplar textures. With the exception of an initial tuning of feature point positions and assignment of texture attribute values, our method is fully automated. In the resulting system, users are assisted in automatically generating or editing a face model by controlling the high‐level parameters. © 2008 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 17, 341–358, 2007
Robust multiscale algorithms for gradient‐based motion estimation
Authors: Lu Qing‐Hua , Zhang Xian‐Min 
Published: April 2008

AbstractGradient‐based techniques represent a very popular class of approaches to estimate motions. A robust multiscale algorithm of hierarchical estimation for gradient‐based motion estimation is proposed in this article using a combination of robust statistical method and multiscale technique. In such a multiscale approach of hierarchical estimation, motion at each level of the pyramid is estimated using different gradient filters. The iterative multiscale estimation begins by using five‐tap central filter, and it is switched to nine‐tap Timoner filter after a few iterations. In addition, robust M‐estimators are applied at each level of the pyramid to overcome the problem of the outliers caused by illumination variations and motion discontinuities in motion estimation. Experimental simulations show that the new algorithm not only provides an improvement in estimator accuracy, but also achieves computational speedups. © 2008 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 17, 333–340, 2007
A 3D modeling and free‐view generation system using environmental stereo cameras
Authors: Kim Hansung , Kim Donghyun , Min Dongbo , Sohn Kwanghoon 
Published: April 2008

AbstractWe propose a 3D video system that uses environmental stereo cameras to display a target object from an arbitrary viewpoint. This system is composed of the following stages: image acquisition, foreground segmentation, depth field estimation, 3D modeling from depth and shape information, and arbitrary view rendering. To create 3D models from captured 2D image pairs, a real‐time segmentation algorithm, a fast depth reconstruction algorithm, and a simple and efficient shape reconstruction method were developed. For viewpoint generation, the 3D surface model is rotated toward the desired place and orientation, and the texture data extracted from the original camera is projected onto this surface. Finally, a real‐time system that demonstrates the use of the aforementioned algorithms was implemented. The generated 3D object can easily be manipulated, e.g., rotated or translated, to render images from different viewpoints. This provides stable scenes of a minimal area that made it possible to understand the target space, and also made it easier for viewers to understand in near real‐time. © 2008 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 17, 367–378, 2007
How social media is transforming employee communications at Sun Microsystems
Authors: Barker Paris 
Published: April 2008

AbstractSun Microsystems' CEO challenged his Global Employee Communications team to build communities within the company with social networking technology. Wikis, blogs, Facebook fan pages, and six islands on Second Life are just a few of Sun's new social media tools that employees use to learn, boost innovation, connect with executives and each other—and spread the good word about Sun. To achieve this quickly, the communications team collaborated across organizational boundaries, tapped grassroots social media efforts in other parts of the company, focused on a manageable number of short‐term projects, and showed a willingness to experiment. © 2008 Wiley Periodicals, Inc.
Transient immunoreactivity after laser tattoo removal: Report of two cases
Authors: Izikson Leonid , Avram Mathew , Anderson R. Rox 
Published: April 2008

AbstractBackground and ObjectiveLaser tattoo removal is one of most commonly used indications for medical lasers. Professional tattoos contain a multitude of potentially immunogenic chemicals that are released or modified by laser treatment. We studied potential immunologic reactions following laser tattoo removal.Study design/Patients and MethodsCase report of two patients with immunologic reactions after laser tattoo removal.ResultsTwo patients developed transient immunoreactivity that presented as regional lymphadenopathy after laser tattoo removal of professional black and blue‐green tattoos. These reactions resolved without any complications.ConclusionsTattoo pigments released or modified by laser therapy may trigger transient immunoreactivity in susceptible individuals. Lesers Surg. Med. 40:231–232, 2008. © 2008 Wiley‐Liss, Inc.
Adaptive sampling in hierarchical simulation
Authors: Knap J. , Barton N. R. , Hornung R. D. , Arsenlis A. , Becker R. , Jefferson D. R. 
Published: April 2008

AbstractWe propose an adaptive sampling methodology for hierarchical multi‐scale simulation. The method utilizes a moving kriging interpolation to significantly reduce the number of evaluations of finer‐scale response functions to provide essential constitutive information to a coarser‐scale simulation model. The underlying interpolation scheme is unstructured and adaptive to handle the transient nature of a simulation. To handle the dynamic construction and searching of a potentially large set of finer‐scale response data, we employ a dynamic metric‐tree database. We study the performance of our adaptive sampling methodology for a two‐level multi‐scale model involving a coarse‐scale finite element simulation and a fine‐scale crystal plasticity‐based constitutive law. Copyright © 2008 John Wiley & Sons, Ltd.
The boundary element‐free method for elastoplastic implicit analysis
Authors: Miers L. S. , Telles J. C. F. 
Published: April 2008

AbstractA meshless procedure, based on boundary integral equations, is proposed to analyze elastoplastic problems. To cope with non‐linear problems, the usual boundary element method introduces domain discretization cells, often considered a ‘drawback’ of the method. Here, to get rid of the standard element and cell, i.e. boundary and domain discretization, the orthogonal moving least squares (also known as improved moving least squares) method is used. The algorithm adopted to solve these particular inelastic non‐linear problems is a well‐established, criterion‐independent implicit procedure, previously developed by the authors. Comparative results are presented at the end to illustrate the effectiveness of the proposed techniques. Copyright © 2008 John Wiley & Sons, Ltd.
Prescribing on psychiatric acute wards at four hospitals
Authors: Hodgson Richard , Sukumaran Manoj K , Sudharsan Srinivasan , Kumar Manoj 
Published: April 2008

AbstractGuidelines for prescribing psychotropic medication are available from a variety of sources; however, the case mix complexity on acute psychiatric wards might be expected to present challenges to adherence to these standards. Dr Hodgson and colleagues set out to audit prescribing on acute psychiatric wards at four hospitals covering similar catchment populations to ascertain practice. Copyright © 2008 Wiley Interface Ltd
The MOGREPS short‐range ensemble prediction system
Authors: Bowler Neill E. , Arribas Alberto , Mylne Kenneth R. , Robertson Kelvyn B. , Beare Sarah E. 
Published: April 2008

AbstractThe Met Office has recently introduced a short‐range ensemble prediction system known as MOGREPS. This system consists of global and regional ensembles, with the global ensemble providing the boundary conditions and initial‐condition perturbations for the regional ensemble. Perturbations to the initial conditions are calculated using the ensemble transform Kalman filter, which is a computationally‐efficient version of the ensemble Kalman filter. Model uncertainties are represented in the system through a series of schemes designed to tackle the structural and subgrid‐scale sources of model error.This paper describes the set‐up of the system, and provides justification for the initial‐condition and model perturbation schemes chosen. An outline of the structure of the perturbations generated by the system is presented, along with performance results, including verification from case studies and routine running.MOGREPS has been on trial within the operational suite at the Met Office since August 2005. On 20 October 2006 it was decided that this system should be made fully operational, with implementation expected in summer 2008. Results show a good performance. The regional ensemble is more skilful than the global ensemble, and compares favourably to the ECMWF ensemble for the forecast variables examined in this study. © Crown Copyright 2008. Reproduced with the permission of the Controller of HMSO and the Queen's Printer for Scotland. Published by John Wiley & Sons,Ltd
QSRR Study of Psychiatric Drugs Using Classification and Regression Trees Combined with Adaptive Neuro‐Fuzzy Inference System
Authors: Jalali‐Heravi Mehdi , Shahbazikhah Parvis , Ghadiri‐Bidhendi Atieh 
Published: April 2008

AbstractA new Quantitative Structure–Retention Relationship (QSRR) approach was carried out for prediction of gas–liquid retention times of 124 psychiatric drugs in whole blood on fused‐silica capillary column coated with crosslinked methylsilicone with nitrogen–phosphorus detection. After screening the descriptors, a total of 699 topological, geometric, and electronic descriptors (zero‐ to three‐dimensional) representing various structural characteristics were calculated for each molecule in the dataset. Combined method of Classification and Regression Tree (CART) as a feature selection method for the extraction of four relevant descriptors and Adaptive Neuro‐Fuzzy Inference System (ANFIS) as a modeling technique was used for the prediction of retention times of diverse set of psychiatric drugs. The Root Mean Square Errors (RMSEs) for the calibration and prediction sets are 0.457 and 0.514, respectively.
Ab initio and DFT calculations of benzaldoxime elimination kinetics in the gas phase
Authors: Mora Jose R. , Cordova Tania , Chuchani Gabriel 
Published: April 2008

AbstractThe mechanism for the gas‐phase molecular elimination kinetics of benzaldoxime was examined at MP2/6‐31G, MP2/6‐31G(d,p), B3LYP/6‐31G, B3LYP/6‐31G(d,p), MPW1PW91/6‐31G, and MPW1PW91/6‐31G(d,p) levels of theory. The products of elimination of this oxime are benzonitrile and water. Calculated thermodynamic and kinetic parameters estimated from B3LYP/6‐31G was found to be in better agreement with the experimental values. Transition state structure is best described as a four‐membered cyclic structure with good approximation to planarity. NBO charges analysis revealed a little greater polarization of the benzylic CδHδ+ rather than NδOHδ−. Bond indexes and synchronicity parameters are in agreement with a concerted semi‐polar type of mechanism with benzylic CH bond breaking as determining step of the reaction. © 2008 Wiley Periodicals, Inc. Int J Quantum Chem, 2008
Rapid screening method for zearalenone in corn, wheat and sorghum
Authors: Holaday Charles E. 
Published: April 2008

AbstractA rapid and sensitive screening method has been developed for zearalenone in corn, wheat and sorghum. The method is based on minicolumn chromatography, and an analysis can be completed in ca. 10 min in most cases. Because several items used are disposable, the amount of cleanup is reduced and the cost per determination is maintained at a low level.
Purification of cyclic fatty acid esters: a GC‐MS study
Authors: Perkins Edward G. , Iwaoka Wayne T. 
Published: April 2008

AbstractGas chromatographic analysis of cyclic monomeric concentrates and fractions from argentation chromatography on packed columns containing SE‐30, OV‐25 and Apiezon L stationary phases yielded incompletely separated peaks representing the various isomers present in the mixture. Somewhat better separation was achieved using a 6 ft×1/8 in. column packed with 15% EGS on Chromosorb W. This column, when coupled to a mass spectrometer, yielded information concerning the composition of each of the isomeric components. Comparable results were obtained using a 50 ft×0.02 in. S.C.O.T. column with DEGS stationary phase and a 150 ft×0.01 in. capillary column coated with Apiezon L. While argentation thin layer chromatography proved useful, an argentation column method using silicic acid coated with 10% AgNO3 proved more efficient for larger scale preparations. Elution of the column with 2% diethyl ether in petroleum ether yielded material essentially free of conjugated linolenate. A comparison of the behavior upon argentation thin layer chromatography of conjugated methyl linolenate, methyl linoleate and cyclic monomer esters indicated that these esters migrated to the same relative position as methyl oleate.
L‐2‐Hydroxyglutaric aciduria: Identification of ten novel mutations in theL2HGDHgene
Authors: Sass J. O. , Jobard F. , Topçu M. , Mahfoud A. , Werlé E. , Cure S. , Al‐Sannaa N. , Alshahwan S. A. , Bataillard M. , Cimbalistiene L. , Grolik C. , Kemmerich V. , Omran H. , Sztriha L. , Tabache M. , Fischer J. 
Published: April 2008

Summaryl‐2‐hydroxyglutaric aciduria (l‐2‐HGA) is a metabolic disease with an autosomal recessive mode of inheritance. It was first reported in 1980. Patients with this disease have mutations in both alleles of theL2HDGHgene. The clinical presentation of individuals with L‐2‐HGA is somewhat variable, but affected individuals typically suffer from progressive neurodegeneration. Analysis of urinary organic acids reveals an increased signal of 2‐hydroxyglutaric acid, mainly as thel‐enantiomer. L‐2‐HGA is known to occur in individuals of various ethnic backgrounds, but up to now mutation analysis has been mainly focused on patients of Turkish and Portuguese origin. This led us to confirm the diagnosis on the DNA level and undertake the corresponding mutation analysis in individuals of diverse ethnicity previously diagnosed withl‐2‐HGA on the basis of urinary metabolites and clinical/neuroimaging data. In 24 individuals from 17 families with diverse ethnic and geographic origins, 13 different mutations were found, 10 of which have not been reported previously. At least eight of the patients were compound heterozygotes. The identification of two mutations (c.751C > T and c.905C > T in exon 7) in patients with different origins supports the view that they occurred independently in different families. In contrast, the mutation c.788C > T was detected in all six Venezuelan patients originating from the same Caribbean island of Margarita, but not in other patients, thus rendering a founder effect likely. None of the mutations was found in the control population, indicating that they are most probably causative. Mutation analysis may improve the quality of diagnosis and prenatal diagnosis of L‐2‐HGA.
Cerebral MRI as a valuable diagnostic tool in Zellweger spectrum patients
Authors: Weller S. , Rosewich H. , Gärtner J. 
Published: April 2008

SummaryPatients with defects in the biogenesis of peroxisomes include those with Zellweger syndrome spectrum (ZSS), a developmental and progressive metabolic disease with a distinct dysmorphic phenotype and varying severity. The diagnosis of ZSS relies on the clinical presentation and the biochemical evaluation of peroxisomal metabolites. Mutation detection in one out of twelve genes coding for proteins involved in the biogenesis of peroxisomes confirms the diagnosis. In the absence of pronounced clinical features of ZSS, neuroradiological findings may lead the way to the diagnosis. Cerebral magnetic resonance imaging (cMRI) pathology in ZSS consists of abnormal gyration pattern including polymicrogyria and pachygyria, leukencephalopathy, germinolytic cysts and heterotopias as reported by previous systematic studies including cMRI of a total of 34 ZSS patients, only five of whom had a severe phenotype. The present study evaluated the cMRI results of additional 18 patients, 6 with a severe and 12 with a milder ZSS phenotype. It confirms and extends knowledge of the characteristic cMRI pattern in ZSS patients. Besides an abnormal gyration pattern and delayed myelination or leukencephalopathy, brain atrophy was a common finding. Polymicrogyria and pachygyria were more common in patients with severe ZSS, while leukencephalopathy increases with age in patients with longer survival. Nevertheless, an abnormal gyration pattern might be more frequent in patients with a mild ZSS than deduced from previous studies. In addition, we discuss the differential diagnosis of the ZSS cMRI pattern and review investigations on the pathogenesis of the ZSS cerebral phenotype in mouse models of the disease.
YIELD STABILITY ANALYSIS OF LATE BLIGHT RESISTANT POTATO SELECTIONS
Authors: MULEMA J. M. K. , ADIPALA E. , OLANYA O. M. , WAGOIRE W. 
Published: April 2008

SUMMARYPotato is an important source of food and income in the highlands of East Africa. Identification of superior genotypes for improved agronomic characteristics will enhance tuber yield. Seven promising clones from population B potato selections (quantitative resistance to late blight) obtained from the International Potato Center, two genotypes from population A (qualitative resistance) and three control cultivars were evaluated for three cropping seasons at four locations in western Uganda in order to determine performance and yield stability. The additive main effects and multiplicative interactive (AMMI) model was used for the analysis. The analysis of variance of yield data for genotypes × locations, genotypes × seasons and genotypes × locations × seasons was significant (p< 0.05) showing the variable response of genotypes and the need for stability analysis. The AMMI statistical model showed that the most stable genotypes were 392618.250 (B5) and 392127.270 (B6) (high yield) and 392618.256 (B1), 391049.255 (B2) and 392127.256 (B7) (low yield) and had negligible interactions with the environments. Across environments, the ranking of genotypes for tuber yield was not consistent. The clones 381471.18 (A2), 387121.4 (A1) and cultivar Victoria had high average yields, but these yields were below average in a few environments. Selective deployment of cultivars can improve tuber yield in the highland tropics.Note: Mention of trade names or commercial products in this publication is solely for the purpose of providing specific information and does not imply recommendation for endorsement by the US Department of Agriculture, Makerere University or Kachwekano Agricultural Research and Development Center.