bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Antifungal Activity of Novel 3‐Anilino‐6‐ethylthio‐4,5‐dihydro‐1,2,4,5‐tetrazines.
Authors: Choudhari J. R. , Berad B. N. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Optimization of 1,4‐Diazepan‐2‐one‐Containing Dipeptidyl Peptidase IV Inhibitors for the Treatment of Type‐2 Diabetes.
Authors: Liang Gui‐Bai , et al. et al. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Strategy for Pyrrolo[1,2‐a][1,4]diazepine Structure Formation.
Authors: Stroganova Tatyana A. , Butin Alexander V. , Vasilin Vladimir K. , Nevolina Tatyana A. , Krapivin Gennady D. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regioselective Anodic Fluorination of α‐(Arylthio)benzylphosphonate Esters, α‐(Arylthio)methylphosphonate Esters and Their Analogues.
Authors: Hidaka Asami , Zagipa Bakenova , Nagura Hirokatsu , Fuchigami Toshio 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Oxidized Humulane Sesquiterpenes from the Basidiomycete Lactarius mitissimus.
Authors: Luo Du‐Qiang , Gao Yuan , Yang Xiao‐Long , Tang Jian‐Guo , Liu Ji‐Kai 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Glucose‐Derived Ionic Liquids: Exploring Low‐Cost Sources for Novel Chiral Solvents.
Authors: Poletti Laura , Chiappe Cinzia , Lay Luigi , Pieraccini Daniela , Polito Laura , Russo Giovanni 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
One‐Pot Synthesis of Novel 2′‐Deoxyuridine Derivatives Containing α‐Aminophosphonate Moieties.
Authors: Shang Zhi‐Qiang , Chen Ru‐Yu , Huang You 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Antiviral Activity of C‐Fluoro‐Branched Cyclopropyl Nucleosides.
Authors: Kim Aihong , Hong Joon Hee 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Nucleosidyl‐peptide Antibiotic, Sansanmycin.
Authors: Xie Yunying , Chen Ruxian , Si Shuyi , Sun Chenghang , Xu Hongzhang 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Conformational Sampling of Bioactive Molecules: A Comparative Study.
Authors: Agrafiotis Dimitris K. , Gibbs Alan C. , Zhu Fangqiang , Izrailev Sergei , Martin Eric 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
QSAR Analyses of Skin Penetration Enhancers.
Authors: Iyer Manisha , Zheng Tao , Hopfinger A. J , Tseng Yufeng J. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Evaluation of a Published in silico Model and Construction of a Novel Bayesian Model for Predicting Phospholipidosis Inducing Potential.
Authors: Pelletier Dennis J. , Gehlhaar Daniel , Tilloy‐Ellul Anne , Johnson Theodore O. , Greene Nigel 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Escherichia coli versus Pseudomonas aeruginosa Deacetylase LpxC Inhibitors Selectivity: Surface and Cavity‐Depth‐Based Analysis.
Authors: Kadam Rameshwar U. , Shivange Amol V. , Roy Nilanjan 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis, Infrared and X‐Ray Diffraction Studies of Mixed Halogen Sodalites and Sodalites Containing Silver Derivatives.
Authors: Borhade A. V. , Wakchaure S. G. , Dholi A. G. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Unit‐Cell‐Level Assembly of Metastable Transition‐Metal Oxides by Pulsed‐Laser Deposition.
Authors: Yan Lei , Niu Hongjun , Bridges Craig A. , Marshall Paul A. , Hadermann Joke , van Tendeloo Gustaav , Chalker Paul R. , Rosseinsky Matthew J. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Discovery of Novel Benzimidazolones as Potent Non‐Nucleoside Reverse Transcriptase Inhibitors Active Against Wild‐Type and Mutant HIV‐1 Strains.
Authors: Barreca Maria Letizia , Rao Angela , De Luca Laura , Iraci Nunzio , Monforte Anna‐Maria , Maga Giovanni , De Clercq Erik , Pannecouque Christophe , Balzarini Jan , Chimirri Alba 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Discovery of 4‐Pyridone Derivatives as Specific Inhibitors of Enoyl‐Acyl Carrier Protein Reductase (Fabl) with Antibacterial Activity Against Staphylococcus aureus.
Authors: Takahata Sho , Iida Maiko , Yoshida Takuji , Kumura Ko , Kitagawa Hideo , Hoshiko Shigeru 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Activity of Quinolinyl‐methylene‐thiazolinones as Potent and Selective Cyclin‐Dependent Kinase 1 Inhibitors.
Authors: Chen Shaoqing , et al. et al. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structure and Magnetism of Spinel Ferrite Nanoparticles and Their Synthesis in Microemulsions
Authors: Mathew Daliya S. , Juang Ruey‐Shin 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Measurement of Gravitomagnetic and Acceleration Fields Around Rotating Superconductors
Authors: Tajmar Martin , Plesescu Florin , Seifert Bernhard , Marhold Klaus 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Magnetoelectric Complex Oxide Heterostructures
Authors: Ramesh R. , Zavaliche F. , Chu Y. H. , Martin L. W. , Yang S. Y. , Cruz M. P. , Barry M. , Lee K. , Yang P. , Zhan Q. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Small and Versatile — Formyl Anion and Dianion Equivalents
Authors: Kirschning Andreas , Kujat Christof , Luiken Silke , Schaumann Ernst 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Miniaturizing Chemistry and Biology in Microdroplets
Authors: Kelly Bernard T. , Baret Jean‐Christophe , Taly Valerie , Griffiths Andrew D. 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Catalytic Syntheses of α‐Branched Chiral Amines
Authors: Braese Stefan , Baumann Thomas , Dahmen Stefan , Vogt Henning 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Strategy to Develop a New Drug for Treatment‐Resistant Depression — Role of Electroconvulsive Stimuli and BDNF
Authors: Li Bingjin , Suemaru Katsuya , Kitamura Yoshihisa , Cui Ranji , Gomita Yutaka , Araki Hiroaki 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structure Elucidation of Organic Compounds from Natural Sources Using 1D and 2D NMR Techniques
Authors: Topcu Gulacti , Ulubelen Ayhan 
Published: August 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Significance of Vectorcardiogram in the Cardiological Diagnosis of the 21st Century
Authors: Pérez Riera Andrés Ricardo , Uchida Augusto H. , Filho Celso Ferreira , Meneghini Adriano , Ferreira Celso , Schapacknik Edgardo , Dubner Sergio , Moffa Paulo 
Published: August 2007

AbstractUntil the mid‐1980s, it was believed that the vectorcardiogram presented a greater specificity, sensitivity and accuracy in comparison to the conventional electrocardiogram, in the diagnosis of the different heart diseases. Recent studies revealed that the vectorcardiogram still is superior to the electrocardiogram in very specific situations, such as in the evaluation of electrically inactive areas, in intraventricular conduction disorders combined and/or in association to inactive areas, in the identification and location of ventricular preexcitation, in the differential diagnosis of patterns varying from normal of electrical axis deviation, in the evaluation of particular aspects of Brugada syndrome, and in the estimation of the severity of some enlargements, among others.With the advent of computerized vectorcardiography, a technology that improves the processing and recording method; a future still promising is expected for this methodology.In the fields of education and research, vectorcardiography provided a better and more rational insight into the electrical phenomena that occurs spatially, and represented an important impact on the progress of electrocardiography. Although a few medical centers still use the method as a routine, we hope that the use of this resource will not get lost over time, since vectorcardiography still represents a source to enrich science by enabling a better morphological interpretation of the electrical phenomena of the heart. Copyright © 2007 Wiley Periodicals, Inc.
Utility of Thoracic Sonography for Follow‐up Examination of Chronic Heart Failure Patients with Previous Decompensation
Authors: Kataoka Hajime 
Published: August 2007

AbstractBackgroundThoracic sonography searching for pleural effusion is helpful in diagnosing heart failure (HF) in emergency situations, but utility of this test for follow‐up examination of chronic HF patient is unknown.HypothesisThoracic sonography searching for pleural effusion may be suitable for monitoring deterioration in chronic HF outpatients during long‐term follow‐up.MethodsPatients with stable HF at the time of study entry, but with previous deterioration (n = 46) were recruited and followed between June 2003 and September 2005. Evaluated HF‐related variables included symptoms and signs of HF, pleural effusion on an ultrasonogram, and B‐type natriuretic peptide (BNP) levels.ResultsDuring the study period, 26 patients developed deterioration in chronic HF and 20 maintained a stable clinical course. Of the 26 patients with deteriorating HF, 25 (96%) demonstrated objective HF‐related sign(s) under examination. Among the signs tested in the present study, pleural effusion on a sonogram was the leading HF‐related sign (77%), followed by rales (46%) and edema (46%). Eleven patients (42%) presented with only one feature, in which pleural effusion on a sonogram was the most frequent (7 of 11 patients). Using plasma BNP levels as a reference for HF deterioration, sonographic detection of pleural effusion exhibited the highest sensitivity (74%), best negative predictive value (73%), and highest predictive accuracy (78%) for identifying patients with higher BNP levels at deterioration compared to stable periods.ConclusionsThoracic sonography allows sensitive detection of HF deterioration and improves clinical decision making in outpatient clinic during follow‐up examination of HF patient with previous decompensation. Copyright © 2007 Wiley Periodicals, Inc.
Prognostic Significance of Atrial Fibrillation is a Function of Left Ventricular Ejection Fraction
Authors: Pai Ramdas G. , Varadarajan Padmini 
Published: August 2007

AbstractBackgroundAtrial fibrillation (AF) has been reported to be associated with decreased survival in population‐based studies. Its prognostic importance in end‐stage heart failure is not clear.Methods and ResultsWe investigated the prognostic implications of AF as function of left ventricular (LV) ejection fraction (EF) in 8,931 consecutive patients undergoing echocardiography at our medical center between 1990 and 1999. Patient characteristics were: age 66 ± 13 years, EF 51 ± 15, AF in 1,203 patients. There were 1,911 deaths over a mean follow up of 913 days. The prevalence of AF was 11% in patients with normal left ventricular ejection fraction (LVEF) (EF ≥ 55%, n = 5, 130), and 18% each in those with mild (EF 41–54%, n = 1209), moderate (EF 26–40%, n = 1183) and severe reductions in left ventricular ejection fraction (LVEF) (EF ≤ 25%, n = 961). The 5‐year survival rate was 72% for those in sinus rhythm compared to 56% for those in AF (p < 0.0001). The effect of AF on 5‐year survival was most pronounced in those with normal LVEF (62 vs 78%, p < 0.0001) followed by those with mild reduction in LVEF (57 vs 72%, p = 0.02). It was not a predictor of survival in those with moderate (5‐year survival 55 vs 61%, p = ns) or severe LV dysfunction (5‐year survival 47 vs 45%, p = ns). Using the Cox regression model, AF was an independent predictor of mortality after correcting for age and LVEF in the entire cohort and in those with normal LVEF, but not in those with reduced LVEF. Among the other co‐morbidities analyzed, an independent effect of AF on mortality was present in those with QTc ≥ 450, raising a possibility of enhanced susceptibility of these patients.ConclusionsThe effect of AF on mortality diminishes with worsening LV function and is absent in those with severe LV dysfunction. Susceptibility of patients with QT prolongation to AF mortality warrants further attention. Copyright © 2007 Wiley Periodicals, Inc.
Adaptive immune responses fail to provide protection against genital HSV‐2 infection in the absence of IL‐15
Authors: Gill Navkiran , Ashkar Ali A. 
Published: August 2007

AbstractIL‐15 plays a crucial role in innate defense against viral infections. The role of IL‐15 in the generation and function of adaptive immunity, following mucosal immunization, against genital HSV‐2 has not been studied. Here, we report that immunized IL‐15–/– mice were able to generate antibody and T cell‐mediated immune responses against HSV‐2, comparable to those seen in immunized B6 mice. However, immunized IL‐15–/– mice were not protected against subsequent HSV‐2 challenge, compared to B6 immunized mice, even with a ten times lower challenge dose. We then examined if the adaptive immune responses generated in the absence of IL‐15 could provide protection against HSV‐2 in an IL‐15‐positive environment. Adoptive transfer of lymphocytes from immunized IL‐15–/– to naive mice were able to provide protection against HSV‐2 challenge similar to protection with immunized cells from control mice. This suggests that the adaptive immune responses raised in the absence of IL‐15 are functional in vivo. Reconstitution of the innate components, particularly IL‐15, NK cells and NK cell‐derived IFN‐γ, in immunized IL‐15–/– mice restored their protective adaptive immunity against subsequent genital HSV‐2 challenge. Our results clearly suggest that innate antiviral activity of IL‐15 is necessary for protective adaptive immunity against genital HSV‐2 infection.
Synthetic multi‐epitope peptides identified in silico induce protective immunity against multiple influenza serotypes
Authors: Stoloff Gregory A. , Caparros‐Wanderley Wilson 
Published: August 2007

AbstractInfluenza causes yearly epidemics of mild disease and, occasionally, pandemics with millions of fatalities. Currently, no vaccine is effective against all influenza strains. Analysis of influenza sequences from animal and human isolates using CLUSTALW and a novel proprietary epitope prediction algorithm identified six conserved T cell‐reactive regions in several proteins. Immunisation of transgenic mice with a preparation of these six regions as chemically synthesised peptides (FLU‐v) induced a specific HLA‐A*0201‐mediated CD8+ T cell response. This T cell population also reacted against human cells infected with three non‐related influenza strains, confirming that the identified regions contain epitopes naturally presented by infected human cells and conserved amongst non‐related viruses. Moreover, FLU‐v immunisation significantly increased survival of transgenic mice against lethal challenge with influenza. Overall, FLU‐v represents a promising influenza vaccine candidate, obviating the need for yearly vaccinations and allowing the stockpiling and initiation of a worldwide vaccination program in advance of a pandemic outbreak.
Molecular mechanisms underlying the synergistic induction of CXCL10 by LPS and IFN‐γ in human neutrophils
Authors: Tamassia Nicola , Calzetti Federica , Ear Thornin , Cloutier Alexandre , Gasperini Sara , Bazzoni Flavia , McDonald Patrick P. , Cassatella Marco A. 
Published: August 2007

AbstractThe CXCL10 chemokine is a critical chemoattractant for the recruitment of activated Th1 and NK cells into inflammatory sites. CXCL10 is typically produced by myeloid cells in response to IFN‐γ, as well as by neutrophils, though the latter require a costimulation with IFN‐γ and LPS. In this study, we investigated the molecular mechanism(s) whereby IFN‐γ and TLR4 ligation synergize to induce CXCL10 expression in neutrophils. By primary transcript real‐time PCR analysis, we demonstrate that the CXCL10 gene is transcriptionally induced by the LPS plus IFN‐γ combination in neutrophils, consistent with previous studies showing that increased CXCL10 gene expression does not reflect enhanced mRNA stability. The IFN‐γ‐induced STAT1 activation and the lipopolysaccharide (LPS)‐induced NF‐κB activation were not enhanced if neutrophils were exposed to both stimuli, whereas both transcription factors were activated by IFN‐γ or LPS in monocytes. Finally, pharmacological inhibitors of NF‐κB demonstrated its role in the induction of CXCL10 expression by LPS plus IFN‐γ in neutrophils, and by LPS or IFN‐γ in monocytes. Together, these results suggest that in neutrophils, the synergy observed between LPS and IFN‐γ toward CXCL10 gene expression likely reflects the cooperative induction of the NF‐κB and STAT1 transcription factors by LPS and IFN‐γ, respectively.
Optimization of Electrochemical Total Creatine Kinase Biosensors Based on Three‐Au‐Electrode
Authors: Cai Xinxia , Liu Chunxiu , Liu Hongmin , Guo Zonghui , Liu Juntao 
Published: August 2007

AbstractFor point‐of‐care examination, total CK (creatine kinase: adenosine‐5‐triphosphate‐creatine phosphotransferase, EC 2.7.3.2) biosensors were developed and optimized. The biosensors were fabricated with three‐Au‐electrode system modified with polyvinylpyridine‐osmium‐wired horseradish peroxidase (PVP‐Os‐HRP) redox polymer film. The reagents were separately immobilized on the single layer biosensor and double layer biosensor which contained lens paper layer and the surface layer of the working electrode. The mediator, the working potential, the structure of working electrode and the stabilizer agent were studied. The biosensor with double reagent layer showed good stability at room temperature (≥2 months) and the biosensor with single reagent layer had excellent response signal (a sensitivity of 11 nA L U−1 cm−2).
Characterization of guanine and guanosine transport in primary cultured rat cortical astrocytes and neurons
Authors: Nagasawa Kazuki , Kawasaki Fumio , Tanaka Akiko , Nagai Katsuhito , Fujimoto Sadaki 
Published: August 2007

AbstractIn this study, we examined the transport mechanisms for guanine and guanosine in rat neurons and astrocytes, and compared their characteristics. In the both types of cell, the uptake of [3H]guanine and [3H]guanosine was time‐, temperature‐, and concentration‐dependent, and Na+‐independent. Their uptake decreased on the addition of purine and pyrimidine nucleobases or nucleosides, and the inhibitory effect of the purine analogues was greater than that of the pyrimidine ones. In both cell types, equilibrative nucleoside transporter (ENT) 1 and ENT2 expression was confirmed at the mRNA level, and nitrobenzylmercaptopurine riboside, a representative inhibitor for ENT, decreased their uptake at concentrations of over 10 μM. Comparing uptake characteristics between the substrates, [3H]guanine uptake exhibited higher affinity and clearance than [3H]guanosine uptake in each type of cell. Although between neurons and astrocytes, there was no difference in the apparent uptake clearance for [3H]guanine and [3H]guanosine, which was calculated based upon the cellular protein content, the cellular uptake clearance was significantly greater in astrocytes than in neurons. These findings indicate that guanine and guanosine, of which the former is a preferable substrate, are taken up into both neurons and astrocytes via ENT2, and that the extracellular concentrations of guanine and guanosine are mainly regulated by astrocytes to maintain brain physiology. © 2007 Wiley‐Liss, Inc.