bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between aneuploidy screening analytes and adverse outcomes in twin gestations
Authors: Yamasato Kelly , Ono Aiwa 
Published: April 2024

Abstract

Objectives
To evaluate associations between serum analytes used for genetic screening and obstetric complications among twin pregnancies.

Methods
This cohort included twins delivered at a tertiary care hospital from 2009 to 2017. Abnormal levels of pregnancy associated plasma protein (PAPP-A), first and second trimester human chorionic gonadotropin (hCG), alpha fetoprotein (AFP), estriol, and inhibin, reported as multiples of the median (MoM), were defined as <5 %ile or >95 %ile for our cohort. Associations between abnormal analytes and preterm delivery, small for gestational age, and pregnancy-associated hypertension were calculated using Fisher’s exact test.

Results
A total of 357 dichorionic/diamniotic and 123 monochorionic/diamniotic twins were included. Among dichorionic/diamniotic twins, elevated AFP (>3.70 MoM) was associated with increased preterm delivery <34 weeks (44.4 vs. 16.5 %, p=0.007), while elevated inhibin (>4.95 MoM) was associated with increased preterm delivery<37 weeks (94.1 vs. 58.8 %, p=0.004). For monochorionic/diamniotic twins, elevated inhibin (>6.34 MoM) was associated increased preterm delivery <34 weeks (66.7 vs. 24.8 %, p=0.04) and hypertension (66.7 vs. 21.4 %, p=0.03).

Conclusions
Selected abnormal analyte levels were associated with increased rates of adverse outcomes in twin pregnancies, which differed by chorionicity. Our findings assist providers in interpreting abnormal analyte levels in twin pregnancies and may help to identify those at increased risk for adverse outcomes.
Gain scheduled internal model control based on the dynamic sliding mode method for the water level of nuclear steam generators
Authors: Farzampanah Farzaneh , Ansarifar GholamReza 
Published: April 2024

Abstract
The Steam Generator (SG) is a crucial component of a nuclear power plant. Proper water level control in a nuclear steam generator is of great importance to ensure a sufficient cooling source for the nuclear reactor and to prevent damage to turbine blades. The water level control problem of steam generators has been a leading cause of unexpected shutdowns in nuclear power plants, which must be addressed for plant safety and availability. The control problem is challenging, particularly at low power levels due to shrink and swell phenomena and flow measurement errors. Furthermore, the dynamics of the steam generator vary as the power level changes. Therefore, there is a need to enhance the water level control system of the SG. In this paper, a Gain Scheduled Internal Model Control (IMC) based on the Dynamic Sliding Mode (DSMC) method is developed for the level control problem. The proposed method exhibits the desired dynamic properties throughout the entire output tracking process, independent of perturbations. Simulation results are presented to demonstrate the effectiveness of the proposed controller in terms of performance, robustness, and stability. The simulation results confirm the improvement in transient response achieved by using the proposed controller.
Study on analysing the potential benefits of utilizing nuclear waste for biodiesel production
Authors: D. Christopher Selvam , Devarajan Yuvarajan , T. Raja 
Published: April 2024

Abstract
This work examines the opportunities and obstacles related to the novel idea of transforming nuclear waste into biodiesel in the Indian setting. Given India’s increasing energy needs and the necessity for sustainable options, repurposing nuclear waste for biodiesel production presents a unique strategy. The paper examines the possible advantages of this approach, covering economic, environmental, and technological factors, as well as discussing the associated difficulties, such as safety issues, technical obstacles, and public perception intricacies. The goal is to provide valuable information for future research and development endeavors by examining India’s distinct nuclear waste and biodiesel environment, considering socio-economic aspects, legislative structures, and the changing energy industry. The paper provides a detailed analysis that adds to the ongoing discussion on sustainable energy choices, emphasizing the significance of creative strategies in addressing energy demands and handling nuclear waste efficiently.
Headless relative clauses with a gap: a typological trait of Mesoamerican languages
Authors: Palancar Enrique L. , Maldonado Roberto Zavala , Chamoreau Claudine 
Published: April 2024

Abstract
This paper has two main goals. One is to introduce a type of “headless” (or “antecedentless”) relative clause that presents a gap strategy and that has not been sufficiently discussed in the typological literature. The other is to show that this type of headless relative clause with a gap is a characteristic trait of Mesoamerican languages, since it exists in many languages of the Mesoamerican linguistic area as an important constructional option in their relativization syntax, independently of the genetic relationships of the language in question. Two types of headless relative clauses are well known to date: one involving a relativization strategy with a relative pronoun (e.g., I wore what you asked me to wear) and another with a light head, introduced by Citko (2004. On headed, headless, and light-headed relatives. Natural Language and Linguistic Theory 22. 95–126), somewhat comparable to I wore the one that you asked me to wear. The third type of headless relative clause discussed here presents a gap (i.e., there is no manifestation of the relativized term in the relative clause). It would be equivalent to saying ‘I wore you asked me to wear’. The phenomenon we study here is interesting both from a typological and areal point of view.
In vitro enzymatic, in silico ADME and molecular docking based analysis for the identification of novel bis-indole containing triazine–thiazole hybrids derivatives as promising urease inhibitors
Authors: Khan Shoaib , Hussain Rafaqat , Khan Yousaf , Iqbal Tayyiaba , Anwar Saeed , Aziz Tariq , Alharbi Metab 
Published: April 2024

Abstract
The current study details a sequence of sequential reactions for synthesizing bis-indole-based triazine bearing thiazole derivatives. Several steps were involved in the synthesis of bis-indole-based triazine bearing thiazole derivative. The synthetic reactions were monitored via thin-layer chromatography (TLC). Synthesized compounds were characterized using various spectroscopic techniques, including 1H NMR, 13C NMR, and HR-EIMS. The inhibitory activity against urease enzyme of these synthesized compounds was compared with that of thiourea, a standard drug (IC50 = 9.30 ± 0.20 µM). A range of inhibitory potencies were observed for the synthesized compounds, ranging from moderate to excellent, as follows (IC50 = 5.10 ± 0.40 µM to 29.80 ± 0.20 µM). Analyzing the structure–activity relationship (SAR) provided insight into the results, showing that different substituents had different effects on aromatic rings. Several compounds displayed outstanding inhibitory properties (among those tested were 1, 2, 4, 5, and 6 with IC50 = 6.30 ± 0.80, 5.10 ± 0.40, 5.90 ± 0.50, 8.20 ± 0.10, 8.90 ± 0.60 µM, respectively). Anti-urease evaluation of all the synthesized derivatives was conducted in which the selected compounds have shown remarkable potency compared with the standard drug thiourea (IC50 = 9.30 ± 0.20 µM). Molecular docking analysis was carried out for investigating the better binding sites and distance of the derivatives. Moreover, the drug-like properties were explored by the ADME attributes of the synthesized analogs.
HISTÓRICO DO ENSINO DA VIDEOCIRURGIA
Authors: Rosa Luciana Walger Collaço Gomes , Collaço Iwan Augusto , Malafaia Osvaldo , Cuenca Ronaldo Mafia , Torres Orlando Jorge Martins , Andreollo Nelson Adami , Tabushi Fernando Issamu 
Published: April 2024

Introdução: Os procedimentos cirúrgicos foram sistematizados e embasados cientificamente no final do século XIX por William Stewart Halsted. Por meio de estudos científicos, princípios anatômicos, conhecimento de fisiologia e patologia que permitiram sistematizar técnica asséptica estrita, manipulação tecidual gentil, dentro de outros. Isto perdurou por séculos. Mas a moderna era tecnológica inventou a videocirurgia e complicou o método de ensino anteriormente usado.
Objetivo: Revisar os métodos de ensino feito por simuladores já publicados.
Método: Trata-se de revisão narrativa realizada nas bases de dados PubMed e Scielo. A busca utilizou as seguintes palavras-chave: videocirurgia, ensino, simuladores, treinamento. Os critérios de inclusão compreenderam artigos de revisão e estudos experimentais, escritos em português e inglês e disponíveis em texto completo. Os trabalhos selecionados foram analisados com base nas tecnologias abordadas, perspectivas futuras e desafios mencionados.
Resultado: Foram incluídos 28 artigos.
Conclusão: Conforme mostram os resultados desta revisão sobre simuladores, os residentes depois de treinados, iniciariam o aprendizado de operações videolaparoscópicas com muito mais facilidade e segurança.
Governança corporativa das empresas estatais com o advento da Lei 13.303/2016: um estudo de caso
Authors: Vieira Flávia Monaco , Pires Vanessa Martins , Finato Neiva Teresinha 
Published: April 2024

<p>O artigo tem como objetivo analisar os impactos da Lei de Responsabilidade das Estatais (LRE) nas estruturas de governança corporativa do Hospital de Clínicas de Porto Alegre (HCPA). Para atender esse objetivo, realizou-se uma pesquisa de natureza qualitativa, que incluiu análise documental e entrevistas semiestruturadas, sendo empregada a análise de conteúdo nos tratamentos dos dados. Como principais resultados, foi possível identificar que a instituição atende, em linhas gerais, aos requisitos previstos na LRE. Em relação ao processo de adequação, a estrutura de governança sofreu uma profunda transformação, que tais mudanças demandaram bastante trabalho e geraram stress, desconforto e medo. Não houve resistência à mudança, embora existisse certo receio em relação à autonomia da gestão do HCPA. Os entrevistados destacam maior profissionalização da estrutura organizacional após a adoção da LRE e melhoria na qualidade das informações geradas pelas áreas administrativo-financeiras. No entanto, alguns desafios permanecem, especialmente quanto aos treinamentos e comunicação dos resultados. Por fim, os resultados obtidos podem contribuir no processo de fortalecimento da governança corporativa das empresas públicas, ao discutir aspectos teóricos e práticos inerente ao processo de adequação à LRE.</p>
Incidence and Predictive Factors of Heart Rhythm Disorders in Acute Coronary Syndrome with ST Segment Elevation
Authors: ZOUZOU Hanane 
Published: April 2024

Background: Heart rhythm disorders in acute coronary syndrome with ST segment elevation are common and may induce hemodynamic instability and sudden death.
Their predictive factors have been the subject of several international studies, as well as their related mortality but their epidemiological data are lacking in Algeria.
Aims: The main objective of our study is the determination of the frequency of heart rhythm disorders in acute coronary syndrome with ST segment elevation; we included conduction disorders, ventricular and supra ventricular arrhythmias; the secondary objective was the analysis of their predictive factors, and related mortality.
Methods and materials: In this prospective study, conducted in the cardiology department of Hussein Dey hospital (Algiers-Algeria), 467 patients with acute coronary syndrome with elevated ST segment (87 women and 380 men) were enrolled between 28 February 2014 and 16 July 2015. The average age is 60 ± 13 years; at admission, a Holter recorder was attached for continuous ECG monitoring during 48 hours.
Kruskal’s ANNOVA or H tests were used for comparison of quantitative variables, χ2 test or Fisher’s exact test, were used for qualitative variables, all tests were performed with 1st species risk of 5%.
Results: The frequency of Heart rhythm disorders is 48.6 % (227 patients), CI 95%: [44.1%-53.1%], multivariate analysis identified the following independent predictors: high ST segment elevation above or equal 6 mm, excessive reciprocal ST segment depression above or equal 2 mm, low diastolic blood pressure less than 60 mm Hg, and cardiac troponin elevation above or equal 5 ng/ml.
The risk of mortality expressed by Hazard Ration (HR) is 71, CI95%: [1.1-3572], p = 0.032; low diastolic blood pressure and Blood creatinine above or equal 17 mg/l are the two predictive factors of mortality, identified in our study.
Conclusion: Heart rhythm disorders are frequent in acute coronary syndrome with elevated ST segment, their predictive factors according to our study are: high ST segment elevation, excessive reciprocal ST segment depression, low diastolic blood pressure, and cardiac troponin elevation.
Their occurrence increases the risk of in-hospital mortality, and the predictors of this latter are hemodynamic instability and high creatinine level.
EMBOSCADA MORTAL E JOGOS POLÍTICOS EM UM FUNERAL
Authors: Cruz Eval 
Published: April 2024

RESUMO: O presente conto tem por objetivo destacar o fenômeno morte como uma questão natural que, inevitavelmente, cedo ou tarde, alcançará a todos seres mortais sem distinção: uns no ventre materno, outros em plena juventude, ou aqueles já bem avançados em idade. Por assim ser, a discussão é travada a partir de um drama em que a morte chega, inesperadamente, à casa de uma dessas famílias campestres e atinge a figura materna daquele lar. O texto destaca também o funeral e as peculiaridades do evento, salientando as características políticas e comportamentais da sociedade em que o incidente aconteceu, bem como a reação da família diante da situação morte.

PALAVRAS CHAVES: Morte, Drama, Funeral.
LOURENÇO MARQUES SOB A MEMÓRIA E O OLHO DE HERTZOG, DE JOÃO PAULO BORGES COELHO
Authors: Carneiro Adriano Guedes 
Published: April 2024

Resumo: O presente artigo tem por objetivo analisar a cidade de Lourenço Marques, a capital colonial de Moçambique, através do olhar de João Paulo Borges Coelho, em seu romance O olho de Hertzog. Sob a perspectiva de uma metaficção historiográfica é colocado em xeque a visão fraturada da história oficial da antiga colônia portuguesa em África. O livro se passa em dois instantes diferentes: campanha militar do General Von Lettow Vorbeck na chamada África oriental alemã, fugindo e lutando com as tropas inglesas e o pós-guerra, em que a personagem Hans Mahrenholz/Henry Miller comparece a Lourenço Marques em busca de um diamante. Em meio à memória e à história, Borges Coelho traça a trama que muito se assemelha a de um romance policial, misturando personagens fictícias e históricas e demonstrando a impossibilidade da história única. Para tanto, utilizamos o pensamento de Walter Benjamin, Gilles Deleuze, Félix Guattari, Carlos Reis, Silvio Renato Jorge, Elena Brugioni, entre outros.

Palavras-Chave: Moçambique; Memória; História; Metaficção; Lourenço Marques.
ENSAIO PARA UM GRITO BRANDO, MÍSTICO E IMPOSSÍVEL: O CANTO INSISTENTE DE OTÁVIO MOTA
Authors: Antunes da Silva Gilson , Pavão Przybylski da Hora Vidal Mauren 
Published: April 2024

Apresentamos, em linhas gerais, a produção ficcional de Otávio Mota, evidenciando os principais aspectos de sua obra. Enfatizamos o viés social e o esperançoso que sobressaem em seus textos sem abandonar a vertente lírico-amorosa também forte nessa produção. A leitura volta-se sobre suas obras Pensar fluidos (1985), Apocalipse Man (1987) e seus poemas publicados nas antologias Valenciando (2005), Rio de letras (2010) e 4 ases e um coringa (2014). Este trabalho aponta para a presença de aspectos épicos e trágicos na ficção otaviana, acompanhados de uma preocupação com os problemas sociais, com o fazer literário, com os aspectos culturais e identitários de sua cidade e, sobretudo, com um desejo de mudança da realidade. A poesia de Otávio Mota é, portanto, crítica, irônica e esperançosa.
The effect of pre-harvest salicylic acid and gibberellic acid applications on-tree storability in ‘Satsuma’ mandarins (Citrus unshiu Marc.)
Authors: Yıldız Kutlar Canan , Şen Fatih 
Published: April 2024

Objective: Satsuma mandarin (Citrus unshiu Marc.), an important export product for Türkiye, is kept on the tree until the beginning of January. This study aimed to determine the effects of single and co-application of salicylic acid (SA) and gibberellic acid (GA3) on the storability of Satsuma mandarin on trees.
Material and Methods: For this purpose, 20 ppm GA₃ two weeks before the color break period, 2 mM SA, and 1.5 ml/L Rezist at the color break period were applied alone and together to Satsuma mandarin fruit. Those without treatment were accepted controls. Various measurements and analyses were made in the samples taken at monthly intervals during storage on the tree.
Results: It was harvested in three periods at approximately one-month intervals from the beginning of November. The applications of SA or GA₃ alone or together limited the fruit drop rate during on-tree storage, the increase in the shell thickness, and the decrease in the specific gravity. Applications involving GA₃ delayed the coloration of fruits. The maturity index of the fruits treated with Resist and GA₃ in the first harvest was lower.
Conclusion: The results showed that the pre-harvest applications of Satsuma mandarin would have positive contributions to the storage of fruits on the tree until the beginning of January by preventing fruit drop, and delaying the peel and fruit aging.
Comparison of Acne Degree among Users of Disposable and KN95 Masks
Authors: Asrinawaty Andi Nur , Salman Mohammad , Sofyan Asrawati 
Published: April 2024

Background: Maskne is a variant of acne that arises from wearing a mask. One factor that influences the incidence of maskne is the type of mask. Purpose: To compare the degree of acne vulgaris in disposable and KN95 mask wearers. Methods: This research was a cross-sectional descriptive study. The sample used was 444 people with acne vulgaris due to the use of disposable and KN95 masks. Acne vulgaris is classified based on the degree of acne. Data were analyzed bivariately using the Chi-square test. Result: This study shows no significant difference between the type of mask and the incidence of acne vulgaris (p = 0.70,p> 0.05). Conclusion: There is no difference in the degree of acne vulgaris in the incidence of maskne in individuals wearing disposable and KN95 masks.
Zoliflodacin, A Novel Antimirobial Agent Against neisseria Gonorhoeae: A Systematic Rreview of Quasi-Experimental Studies
Authors: Matthew Franklind , Stella Maureen Miracle , Tandarto Kevin , Regina Regina 
Published: April 2024

Background: The gram-negative bacteria Neisseria gonorrhoeae is the source of the STI known as gonorrhea. N. gonorrhoeae can adapt well to humans as a host and become a pathogen with sophisticated mechanisms to avoid the innate immune response as well as suppress the adaptive immune response. Lately, zoliflodacin was shown to have antibacterial activity against N. gonorrhoeae. Purpose: The aim of this study is to evaluate the antibacterial activity of zoliflodacin against N. gonorrhoeae. Methods: We followed the PRISMA 2020 guidelines to systematically search and collect literature in the following databases: ProQuest, EBSCOhost, PubMed, ScienceDirect, Taylor&Francis, SAGE, JSTOR, and Wiley, without time limitation (until October 9th, 2022). Titles and abstracts were reviewed for relevance. The inclusion criteria were original article written in English that investigated the effects of zoliflodacin in patients with gonorrhea. From 177 studies, we retrieved five studies for this study, published between 2015 and 2021. Results: Zoliflodacin was highly active in vitro against N. gonorrhoeae isolates from European countries, China, Thailand, and South Africa, and also showed potent antimicrobial activity against multi-resistant N. gonorrhoeae isolates in South Korea. There were three different kinds of minimum inhibitory concentration (MIC) evaluated, with the following results: modal MIC (0.064-0.25 μg/mL), MIC50 (0.03-0.125 μg/mL), and MIC90 (0.06-0.25 μg/mL). There was no cross-resistance to antimicrobials currently or previously used for gonorrhea treatment. This MIC range could be used for further studies.
Analyse des médias en LEA : approche critique et créative de l’interculturalité comme levier pédagogique
Authors: Grillo Sabrina 
Published: April 2024

L’article aborde la médiaculture et la transversalité dans l'enseignement des Langues Étrangères Appliquées (LEA) et met en avant une étude de cas pédagogique portant sur l’histoire et la culture de l'Espagne. Il explore comment à travers le cours de civilisation, il est possible de tirer profit de l’analyse de la communication et de ses effets du fait de la pluridisciplinarité du cours de LEA d’une part et de la transversalité de ce cours d’autre part. C’est le développement des compétences interculturelles avec un accent particulier sur l'analyse des médias, la créativité, et la préparation des étudiants aux défis du monde professionnel qui sont visés. L’article expose un retour d’expérience en Licence à partir de la question suivante : en quoi l’analyse des médias dans le cours de civilisation en LEA peut-elle contribuer à développer divers savoirs et savoir-faire utiles dans le milieu professionnel sur des questions d'interculturalité et de marketing ? L’étude de cas proposée met l'accent sur l'approche de la médiaculture pour enseigner la communication et la compréhension interculturelle, en tenant compte des influences des médias sur la construction de la réalité sociale. Les atouts et inconvénients issus de ce retour d’expérience font l’objet d’une analyse finale.
Early Formation of a Tenosynovial Retinacular Cyst Between A1 and A2 Pulleys After Open A1 Pulley Release
Authors: Haddad Daniel K. , Scheer Ryan C. , Filtes Peter , Coyle Ryan M. 
Published: April 2024

Case:
A 66-year-old woman presented with a left middle trigger finger and underwent a proximal annular pulley (A1) release. Four weeks later, she presented with a new mass in the same finger without recurrent triggering. She was found to have a tenosynovial retinacular cyst, which was surgically excised.

Conclusion:
This case demonstrates early ganglion cyst formation between A1 and A2 pulleys after A1 pulley release. Although the etiology is unclear, this case illustrates effective treatment strategies.
Team Approach: Neuromuscular Training for Primary and Secondary Prevention of Anterior Cruciate Ligament Injury
Authors: Inclan Paul M. , Hicks Justin J. , Retzky Julia S. , Janosky Joseph J. , Pearle Andrew D. 
Published: April 2024

» Neuromuscular training is a method of performance optimization—typically combining plyometrics, balancing training, agility, and dynamic stabilization—predicated on improving the efficiency of fundamental movement patterns.» Neuromuscular training has consistently been shown to reduce the risk of anterior cruciate ligament injury, particularly for athletes engaged in activities associated with noncontact knee injuries (i.e., women's soccer).» Successful implementation of neuromuscular training programs requires input from coaches, physical therapists, athletic trainers, and physicians to generate efficacious programs with high rates of adherence.