bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transforming Growth Factor β Signaling Pathway as a Potential Drug Target in Treating Aortic Diseases
Authors: Liu Zijie , Song Tianyu , Xie Liping 
Published: March 2024

Review
Transforming Growth Factor β Signaling Pathway as a Potential Drug Target in Treating Aortic Diseases

Zijie Liu 1,2, Tianyu Song 3, and Liping Xie 1,2,3, *

1 Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China
2 School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China
3 ‍Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Nanjing Medical University, Nanjing 211166, China
* Correspondence: lipingxie@njmu.edu.cn

Received: 16 October 2023
Accepted: 20 November 2023
Published: 6 March 2024

Abstract: The transforming growth factor β (TGF-‍β) signaling pathway is crucial for preserving the structural homeostasis of the aorta and promoting aortic development. This pathway encompasses both SMAD-dependent canonical pathway and SMAD-independent non-canonical signaling pathway. Heritable thoracic aortic aneurysms and dissection are highly correlated with genetic alterations in TGF-‍β canonical signaling-related genes. However, depending on the stage of the disease, the TGF-‍β signaling pathway can have either inhibitory or aggravation effects, making its roles in aortic disease complex and occasionally contradictory. This review aims to elucidate the biological mechanisms underlying the TGF-‍β signaling pathway in the most common aortic diseases, namely acute aortic syndromes and aortic aneurysms, and to evaluate the potential clinical application of TGF-β-targeting therapies in aortic diseases.
ANALISA BAHAN KARET SEBAGAI PEREDAM GETARAN PADA JOINT COUPLING TANK FV101 SCORPION
Authors: Iman Ilham Fajar , Setiyawan Rahmadani  , Hidayat Muhammad Iman 
Published: March 2024

Salah satu aplikasi penting dari peredaman getaran adalah pada joint coupling tank, khususnya pada kendaraan militer seperti tank FV101 Scorpion. Joint coupling adalah komponen yang sangat penting pada komponen mesin pada tank scorpion. Komponen ini berfungsi untuk penghubung antara mesin dengan rangkaian transmisi pada tank scorpion. Tujuan penelitian ini yaitu untuk mendalaminya secara lebih rinci dan mendapatkan pemahaman yang lebih akurat tentang bagaimana bahan karet dapat efektif berperan dalam meredam getaran pada komponen kritis, seperti joint coupling tank pada tank FV101 Scorpion. Metode penelitian yang digunakan yaitu pengujian mekanik dan uji vulkanisasi dari beberapa spesimen yang merupakan campuran dari beberapa material. Dari hasil penelitian menunjukkan spesimen dengan kompon campuran material dalam gram yaitu NR (75), SBR (25), ZnO (10), Stearic Acid (2), IPPD (3), Flexton (1) Carbon Black (75), CBS (1), Sulfur (2,5) dan Mineral (5) memeliki hasil uji mekanik dan uji vulkanisasi yang lebih baik dari spesimen lainnya yang ada dalam penelitian ini. Berdasarkan hasil ini dapat disimpulkan spesimen dengan campuran tersebut mempunyai kemampuan sebagai karet peredam pada joint coupling tank .
Trends in the Adoption of Outpatient Joint Arthroplasties and Patient Risk: A Retrospective Analysis of 2019 to 2021 Medicare Claims Data
Authors: Fedorka Catherine J. , Srikumaran Uma , Abboud Joseph A. , Liu Harry , Zhang Xiaoran , Kirsch Jacob M. , Simon Jason E. , Best Matthew J. , Khan Adam Z. , Armstrong April D. , Warner Jon J.P. , Fares Mohamad Y. , Costouros John , O'Donnell Evan A. , Beck da Silva Etges Ana Paula , Jones Porter , Haas Derek A. , Gottschalk Michael B. ,   The Avant-Garde Health and Codman Shoulder Society Value-Based Care Group
Published: March 2024

Introduction:
Total joint arthroplasties (TJAs) have recently been shifting toward outpatient arthroplasty. This study aims to explore recent trends in outpatient total joint arthroplasty (TJA) procedures and examine whether patients with a higher comorbidity burden are undergoing outpatient arthroplasty.

Methods:
Medicare fee-for-service claims were screened for patients who underwent total hip, knee, or shoulder arthroplasty procedures between January 2019 and December 2022. The procedure was considered to be outpatient if the patient was discharged on the same date of the procedure. The Hierarchical Condition Category Score (HCC) and the Charlson Comorbidity Index (CCI) scores were used to assess patient comorbidity burden. Patient adverse outcomes included all-cause hospital readmission, mortality, and postoperative complications. Logistic regression analyses were used to evaluate if higher HCC/CCI scores were associated with adverse patient outcomes.

Results:
A total of 69,520, 116,411, and 41,922 respective total knee, hip, and shoulder arthroplasties were identified, respectively. Despite earlier removal from the inpatient-only list, outpatient knee and hip surgical volume did not markedly increase until the pandemic started. By 2022Q4, 16%, 23%, and 36% of hip, knee, and shoulder arthroplasties were discharged on the same day of surgery, respectively. Both HCC and CCI risk scores in outpatients increased over time (P < 0.001).

Discussion:
TJA procedures are shifting toward outpatient surgery over time, largely driven by the COVID-19 pandemic. TJA outpatients' HCC and CCI risk scores increased over this same period, and additional research to determine the effects of this should be pursued.

Level of evidence:
Level III, therapeutic retrospective cohort study.
“On the Side of the Good”: Political Alliances of Religious Zionists and Israeli Conservatism in the Quest to Hegemony
Authors: Miller Mordy , Katsman Hayim 
Published: March 2024

This article discusses the recent political alliance between IC and the “Hardal” (acronym for Haredi-Dati-Leumi, meaning Ultra-Orthodox-Religious-Zionists) followers of Rabbi Zvi Thau. This new cooperation is surprising, due to Thau’s tendency to criticize groups that do not adhere to his strict interpretation of Judaism. In this article we analyze the recent developments within Thau’s circle, and determine that this cooperation is a consequence of a unique interpretation of a spiritual state of emergency. We conclude by analyzing the circumstances in which IC was formed, as a lesson religious Zionists took from the 2005 disengagement from Gaza plan. The article demonstrates that IC intentionally intended to enable the creation of this sort of political alliance.
Pengaruh Ukuran Dewan Komisaris Terhadap Return On Aset Perusahaan Perbankan Syariah Di Bei
Authors: Wijaya Ricky 
Published: March 2024

Yang menjadi tujuan dalam penelitian ini adalah untuk menganalisis pengaruh ukuran dewan komisaris terhadap Return on Aset pada perusahaan perbankan syariah di BEI. Menggunakan metode penelitian kuantitatif, Sampel dalam penelitian ini adalah perusahaan perbankan syariah yang go public di BEI, dengan hasil menunjukkan variabel ukuran dewan komisaris yang tidak berpengaruh secara parsial terhadap Return on Aset, dengan nilai constant = 172,155, X= 2,325 dengan nilai signifikan pada variabel Ukuran Dewan Komisaris 0,000 < 0,05. Maka untuk hipotesis penelitian dapat di terima, yaitu Terdapat pengaruh yang signifikan antara Ukuran Dewan Komisaris terhadap Return On Aset, secara parsial
Perancanaan Strategi Digital Marketing Sebagai Upaya Pencapain Strategi Pemasaran Pada Toko Kue Darel Prabumulih
Authors: Halin Hamid , Ramayani Rika Fitri 
Published: March 2024

Program Pengabdian Masyarakat di lakukan oleh klaborasi dosen Universitas Indo Global Mandiri Palembang dan Universitas Prabumulih pada tahun 2024. Tujuan yang ingin dicapai dalam kegiatan ini adalah untuk menjadikan kebiasaan masyarakat banyak mengalami perubahan dan lebih praktis. Sebagai seorang pebisnis beradaptasi dengan perubahan zaman tidaklah demikian mudah. Perlu adanya wadah untuk mengembangkan pengetahuan dan keterampilan di dalamnya perencanaan startegi bisnis secara digitalisasi, khususnya di bidang pemasaran. Kegiatan ini adalah dilakukan agar para pelaku usaha yaitu Toko Kue Darel Prabumulih dapat pencapaian pemasaran lebih luas dan meningkat. Kegiatan ini dilakukan dalam lima tahapannya yaitu dengan melakukan survei terhadap toko kue Darel Prabumulih dengan menggunakan wawancara, sosialisasi, re-branding, pendampingan foto produk, dan pendampingan dalam menciptakan media sosial dan e-commerce. metode dilakukan langsung dan simulasi secara lansung. Proses pemasaran bisa digunakan berbasis teknologi kami beharap dengan pengabdian kepada masyarakat ini dapat membuka para pelaku usaha Kue Darel Prabumulih dalam memasarkan secara online dan meningkatkan pendapatan.
Rikkunshito increases peripheral incretin-hormone levels in humans and rats
Authors: Kono Hiroshi , Furuya Shinji , Akaike Hidenori , Shoda Katsutoshi , Kawaguchi Yoshihiko , Amemiya Hidetake , Kawaida Hiromichi , Ichikawa Daisuke 
Published: March 2024

BACKGROUND
It was reported that rikkunshito (TJ-43) improved the cisplatin-induced decreases in the active form of ghrelin in plasma; however, other effects on gastrointestinal hormones have not been investigated.
AIM
To investigate the effects of TJ-43 on peripheral levels of incretin hormones, including gastric inhibitory polypeptide (GIP) and glucagon-like polypeptide-1 (GLP-1), in humans and rats.
METHODS
Patients were divided into two groups, namely patients who received TJ-43 immediately following surgery [TJ-43(+) group] and those who received TJ-43 on postoperative day 21 [TJ-43(-) group], and the plasma levels of active GIP and active GLP-1 were assessed. In animal experiments, rats were treated with TJ-43 [rat (r)TJ-43(+) group] or without [rTJ-43(−) group] by gavage for 4 wk, and the plasma active GIP and active GLP-1 levels were measured. The expression of incretin hormones in the gastrointestinal tract and insulin in the pancreas were investigated by immunohistochemistry. Furthermore, the cyclic adenosine monophosphate activities were assessed in pancreatic tissues from rats treated with or without TJ-43 in vivo , and the blood glucose levels and plasma insulin levels were measured in rats treated with or without TJ-43 in oral glucose tolerance tests.
RESULTS
In humans, the active incretin hormone levels increased, and values were significantly greater in the TJ-43(+) group compared those in the TJ-43(-) group. In rats, the plasma active incretin levels significantly increased in the rTJ-43(+) group compared with those in the rTJ-43(-) group. GIP and GLP-1 expressions were enhanced by TJ-43 treatment. Moreover, plasma insulin levels increased and blood glucose levels were blunted in the rTJ-43(+) group.
CONCLUSION
The results show that TJ-43 may be beneficial for patients who undergo pancreatic surgery.
Duodenal Crohn’s disease: Case report and systematic review
Authors: Amadu Muniratu , Soldera Jonathan 
Published: March 2024

BACKGROUND
Inflammatory bowel disease, including ulcerative colitis, microscopic colitis, and Crohn’s disease (CD), has a global impact. This review focuses on duodenal CD (DCD), a rare subtype affecting the duodenum. DCD’s rarity and asymptomatic nature create diagnostic challenges, impacting prognosis and patient well-being. Delayed diagnosis can worsen DCD outcomes.
AIM
To report a rare case of DCD and to discuss the diagnostic challenges and its implications on prognosis.
METHODS
A systematic literature search, following the PRISMA statement, was conducted. Relevant studies were identified and analysed using specific Medical Subject Terms (MeSH) from PubMed/MEDLINE, American Journal of Gastroenterology, and the University of South Wales database. Data collection included information from radiology scans, endoscopy procedures, biopsies, and histopathology results.
RESULTS
The review considered 8 case reports and 1 observational study, involving 44 participants diagnosed with DCD, some of whom developed complications due to delayed diagnosis. Various diagnostic methods were employed, as there is no gold standard workup for DCD. Radiology scans [magnetic resonance imaging (MRI), computed tomography (CT), and upper gastrointestinal X-ray], endoscopy procedures (colonoscopy and esophagogastroduodenoscopy), biopsies, and clinical suspicions were utilized.
CONCLUSION
This review discusses DCD diagnosis challenges and the roles of CT, MRI, and fluoroscopy. It notes their limitations and compares findings with endoscopy and histopathology studies. Further research is needed to improve diagnosis, emphasizing scan interpretation, endoscopy procedures, and biopsies, especially in high-risk patients during routine endoscopy.
Technical note for intraoperative determination of proper acetabular cup size in primary total hip arthroplasty
Authors: Karampinas Panagiotis , Vlamis John , Galanis Athanasios , Vavourakis Michail , Krexi Anastasia , Sakellariou Evangelos , Patilas Christos , Pneumaticos Spiros 
Published: March 2024

BACKGROUND
Selecting the optimal size of components is crucial when performing a primary total hip arthroplasty. Implanting the accurate size of the acetabular component can occasionally be exacting, chiefly for surgeons with little experience, whilst the complications of imprecise acetabular sizing or over-reaming can be potentially devastating.
AIM
To assist clinicians intraoperatively with a simple and repeatable tip in elucidating the ambivalence when determining the proper acetabular component size is not straightforwardly achieved, specifically when surgeons are inexperienced or preoperative templating is unavailable.
METHODS
This method was employed in 263 operations in our department from June 2021 to December 2022. All operations were performed by the same team of joint reconstruction surgeons, employing a typical posterior hip approach technique. The types of acetabular shells implanted were: The Dynasty® acetabular cup system (MicroPort Orthopedics, Shanghai, China) and the R3® acetabular system (Smith & Nephew, Watford, United Kingdom), which both feature cementless press-fit design.
RESULTS
The mean value of all cases was calculated and collated with each other. We distinguished as oversized an implanted acetabular shell when its size was > 2 mm larger than the size of the acetabular size indicator reamer (ASIR) or when the implanted shell was larger than 4 mm compared to the preoperative planned cup. The median size of the implanted acetabular shell was 52 (48–54) mm, while the median size of the preoperatively planned cup was 50 (48–56) mm, and the median size of the ASIR was 52 (50–54) mm. The correlation coefficient between ASIR size and implanted acetabular component size exhibited a high positive correlation with r = 0.719 (P < 0.001). Contrariwise, intraoperative ASIR measurements precisely predicted the implanted cups’ size or differed by only one size (2 mm) in 245 cases.
CONCLUSION
In our study, we demonstrated that the size of the first acetabular reamer not entering freely in the acetabular rim corroborates the final acetabular component size to implant. This was also corresponding in the majority of the cases with conventional preoperative templating. It can be featured as a valid tool for avoiding the potentially pernicious complications of acetabular cup over-reaming and over-sizing in primary total hip arthroplasty. It is a simple and reproducible technical note useful for confirming the predicted acetabular cup size preoperatively; thus, its application could be considered routinely, even in cases where preoperative templating is unavailable.
De la classe spéciale à la classe régulière
Authors: Bovey Laurent 
Published: March 2024

Depuis une vingtaine d’années en Suisse, le « taux de séparation scolaire », c’est-à-dire le nombre d’élèves scolarisés en classe spéciale ou en établissement de pédagogie spécialisée, ne cesse de diminuer. Une partie des classes spéciales ont fermé et les élèves ont été réintégrés en classe régulière. Une autre partie de ces classes ont été transformées en dispositifs plus flexibles favorisant une plus grande mobilité des élèves. Deux recherches menées auprès d’élèves bénéficiant de mesures de pédagogie spécialisée dans le canton de Vaud montrent qu’une partie de ces élèves restent dans les faits séparés à l’intérieur des classes régulières, au fond de la classe, dans le couloir, dans un local de dégagement ou accompagnés une grande partie du temps par des enseignants et enseignantes spécialisées ou des assistants et assistantes à l’intégration. En outre, les élèves (ré)intégrés sont soumis à de nombreuses attentes comportementales et sont évalués en permanence, ce qui les pousse à mettre en place des stratégies complexes pour s’adapter aux exigences de la classe régulière.
Formação continuada de professores e mensuração educacional:
Authors: Mayer Luana 
Published: March 2024

O objetivo deste artigo é analisar como a mensuração educacional de um sistema de ensino bilíngue afeta a formação continuada de professores bilíngues com base em eventos do meu cotidiano de trabalho enquanto formadora de professores, atuando em escolas privadas no interior do estado de São Paulo, vinculada a um sistema de ensino, em um contexto chamado “bilíngue de elite” (CAVALCANTI, 1999). A discussão, recorte de uma pesquisa autoetnográfica (ADAMS, HOLMAN JONES & ELLIS, 2022) de doutorado, parte de registros em diário de campo e eventos relacionados à mensuração educacional do sistema de ensino que deram corpo à análise. Como dispositivo teórico-analítico, os preceitos autoetnográficos de Chang (2016) foram observados, bem como o conceito de boa educação (BIESTA, 2012), inovação e constelação de práticas sociais inter-relacionadas (SIGNORINI, 2007). Os resultados indicam que os sistemas de ensino bilíngue se expandem baseados no discurso de que “não se aprende a falar inglês na escola” e, nesse compasso, na ideia de que “os professores não sabem dar aulas”. Ainda, a mensuração educacional no sistema de educação bilíngue valoriza dados que medem o que é possível medir, e não o que é desejável em termos de boa educação. Assim, a existência de sistemas bilíngues de ensino e também a orientação a partir da mensuração educacional que os sistemas realizam esvazia o potencial caráter crítico da formação continuada de professores bilíngues, e se torna um espaço de confronto entre as expectativas de diferentes agentes institucionais envolvidos nessa estrutura.
Identifikasi Kesulitan Guru dalam Pengelolaan Kelas di SMK Ihyaul Ulum Dukun Gresik
Authors: M Reihan Hardisyah P  , Nur Maulidah Umi F  , Abdullah Zaini  
Published: March 2024

Penelitian ini bertujuan untuk mengetahui tentang kesulitan guru dalam mengelola kelas beserta faktor penyebab dan juga solusi yang bisa dilakukan untuk mengatasi kesulitan dalam pengelolaan kelas di SMK Ihyaul Ulum Gresik. Dalam penelitian ini penulis memilih metode penelitian deskriptif kualitatif. Subjek dalam penelitian kali ini adalah seorang guru di SMK Ihyaul Ulum Gresik. Teknik pengumpulan data menggunakan teknik wawancara terstruktur dan dokumentasi. Dalam penelitian ini menggunakan teknik analisis data dari Miles dan Huberman untuk analis data seperti reduksi, penyajian dan penarikan kesimpulan data. Dari hasil penelitian diperoleh informasi tentang kesulitan seorang guru dalam menjalankan pengelolaan kelas seperti kesulitan dalam mengatur disiplin siswa, kesulitan mengatur tingkah laku murid, dan kesulitan mengatur sumber dan metode pengajaran. Faktor yang mempengaruhi kesulitan guru dalam mengelola kelas seperti faktor murid, faktor guru dan fasilitas sekolah itu sendiri. Solusi yang bisa diambil untuk mengatasi permasalahan tersebut adalah dengan memperbaiki metode pengajaran, memberi pendekatan dan juga bimbingan, memilih dan memodifikasi metode serta bahan ajar yang tepat, yang terakhir mengadakan diskusi untuk evaluasi dengan pengajar lain dan juga pimpinan atau kepala sekolah.
In Closing … On Schooling and Fabricated Cats
Authors: Dredger Katie Shepherd 
Published: March 2024

Sending her daughter to kindergarten motivates this educator to pen a short essay on the value of schooling and the tensions that are created between the group and the individual.Â Musing on the writings of some of the great and often controversial curriculum theorists, Dredger questions even her own beliefs.Â She concludes with the hope that her daughter, just one representative of all school children, will manage to thrive in a world of conflicting expectations and awesome possibilities.
ВИКОРИСТАННЯ КЕЙС-ТЕХНОЛОГІЙ ПІД ЧАС ВИКЛАДАННЯ ДИСЦИПЛІН ВІЙСЬКОВО-ПРОФЕСІЙНОГО СПРЯМУВАННЯ У ПІДГОТОВЦІ МАЙБУТНІХ ОФІЦЕРІВ НАЦІОНАЛЬНОЇ ГВАРДІЇ УКРАЇНИ
Authors: Плаксін Андрій 
Published: March 2024

У статті проаналізовано актуальні наукові дослідження і публікації щодо розроблення та апробації інноваційних методів навчання, спрямованих на підвищення якості отриманих знань здобувачами вищої освіти. Розглянуто вплив кейс-технологій на ефективність навчальної діяльності здобувачів вищої освіти під час викладання дисциплін військово-професійного спрямування.
Описано види кейс-технологій, особливості їх створення та використання, а також принципи розро- блення. Кейс-технології розглянуто в контексті інноваційних інтерактивних методів навчання. Закцен- товано увагу на впливі означених технологій на формування професійної компетентності майбутнього офіцера Національної гвардії України.
Зазначено, що інструментом вдосконалення військової освіти є інноваційна діяльність, яка полягає у внесенні якісно нових елементів в освітній процес. Прогресивна педагогічна спільнота пропонує нові тех- нології, інший педагогічний менталітет. Реалізація нових векторів розвитку в діяльності вищих військових закладів освіти потребує використання інноваційних педагогічних технологій, творчого пошуку нових кон- цепцій, принципів, підходів до надання освітніх послуг.
Обґрунтовано, що кейс-метод нині варто активно застосовувати у підготовці військових фахівців, оскільки він відповідає потребам часу і має значні можливості. Це інтерактивний метод навчання, який дає змогу наблизити процес навчання майбутніх офіцерів підрозділів Національної гвардії України до реальної службово- бойової діяльності. Він сприяє розвитку винахідливості, вмінню виконувати поставленні завдання та вирішувати проблеми, що виникають при їх виконанні, забезпечує розвиток здібностей проводити їх аналіз і діагностику.
ОБҐРУНТУВАННЯ НЕОБХІДНОСТІ ПІДГОТОВКИ ФАХІВЦІВ З МОРАЛЬНО-ПСИХОЛОГІЧНОГО ЗАБЕЗПЕЧЕННЯ ДЛЯ ПІДРОЗДІЛІВ НАЦІОНАЛЬНОЇ ГВАРДІЇ УКРАЇНИ
Authors: Медвідь Михайло , Ковтонюк Олександр , Медвідь Юлія 
Published: March 2024

У статті за результатами проведеного дослідження обґрунтовано необхідність підготовки майбутніх офіцерів Національної гвардії України (НГУ) для посад заступника командира підрозділу по роботі з особовим складом за освітньою програмою «Морально-психологічне забезпечення підрозділів НГУ» або «Соціально-правове забезпечення підрозділів НГУ» спеціальності 254 Забезпечення військ (сил). Здійснення підготовки майбутніх офіцерів для інших посад має враховувати вивчення навчальної дисципліни «Морально-психологічне забезпечення підготовки та застосування військових формувань». Запропоновано елементи методики реалізації змістових модулів цієї дисципліни.