bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of HCAR2 antagonists as a potential strategy to modulate bovine leukocytes
Authors: Mamedova Laman K. , Krogstad Kirby C. , McDonald Paiton O. , Pokhrel Laxman , Hua Duy H. , Titgemeyer Evan C. , Bradford Barry J. 
Published: March 2024

Abstract
Background
Dairy cows experiencing ketosis after calving suffer greater disease incidence and are at greater risk of leaving the herd. In vitro administration of beta-hydroxybutyric acid (BHBA; the primary blood ketone) has inhibitory effects on the function of bovine leukocytes. BHBA is a ligand of HCAR2 and the activation of these receptors promotes an anti-inflammatory response which may be related with immunosuppression observed in transition dairy cattle. The objective of this study was to identify and test antagonists for HCAR2 in bovine immune cells cultured with BHBA.

Results
We observed expression of HCAR2 at the protein level within lymphocytes, monocytes, and granulocytes. The proportion of cells expressing HCAR2 tended to be greater in mid-lactation compared to early lactation cows; the increase was a result of increased proportion of T and B cells expressing HCAR2. Stimulation of HCAR2 with niacin or BHBA promoted Ca2+ mobilization in neutrophils and mononuclear cells. Mononuclear cells treated with BHBA had diminished intracellular Ca2+ responses when HCAR2 was knocked down by siRNA silencing, indicating Ca2+ mobilization was mediated by HCAR2 signaling. Two candidate antagonists for HCAR2, synthesized from niacin (NA-1 and NA-5), were tested; monocytes and neutrophils pre-treated with NA-1 and NA-5 had reduced Ca2+ mobilization after incubation with BHBA. Furthermore, NA-5 but not NA-1 prevented BHBA-associated reductions in cyclic AMP.

Conclusions
We demonstrated that HCAR2 is present on bovine leukocytes and has greater expression later in lactation. We confirmed that BHBA and niacin derived HCAR2 antagonists alter bovine leukocyte activity. Our results demonstrate that both BHBA and niacin affect bovine leukocyte Ca2+ mobilization in a HCAR2-dependent manner.
Developing an ontological model for Xinjiang unearthed brocades
Authors: Zhao Yu , Li Zhou , Li Wenliang , Liu Junling 
Published: March 2024

Abstract
The Xinjiang unearthed brocade as a significant cultural heritage records the historical and cultural information of diverse ethnic groups, and it also influences cultural product development. However, the existing knowledge concerning these brocades is disorganized, fragmented, and incomplete, hindering a comprehensive understanding of their intricate relationships. To address these issues, this study has developed an integrated ontological model for Xinjiang’s unearthed brocades (XJUBontology). By applying Conceptual Reference Model of International Committee for Documentation (CIDOC CRM) ontology and the Remanufactured Process Planning (RPP) approach, this XJUBontology comprises knowledge about both the brocades and their cultural derivatives, and knowledge in these two domains are able to be organized and refined. The implementation of XJUBontology in Protégé and validation via SPARQL queries not only centralize and manage Xinjiang unearthed brocade-related knowledge but also establish vital connections among this fragmented information. The contribution is to help in associating, managing, and sharing knowledge in the domain of Xinjiang unearthed brocades, providing a framework for establishing related data repository, and helping researchers, apparel and accessories designers, museums, and other cultural and tourism institutions to access a more systematic information to assist their works.
Intelligent techniques and optimization algorithms in textile colour management: a systematic review of applications and prediction accuracy
Authors: Liu Senbiao , Liu Yaohui Keane , Lo Kwan-yu Chris , Kan Chi-wai 
Published: March 2024

AbstractBased on a selection of 101 articles published from 2013 to 2022, this study systematically reviews the application of intelligent techniques and optimization algorithms in textile colour management. Specifically, the study explores how these techniques have been applied to four subfields within textile colour management: colour matching and prediction, colour difference detection and assessment, colour recognition and segmentation, and dye solution concentration and decolourization. Following an introduction to intelligent techniques and optimization algorithms in textile colour management, the study describes the specific applications of these techniques in the field over the past decade. Descriptive statistics are used to analyse trends in the use of these techniques and optimization algorithms, and comparative performances indicate the effectiveness of the techniques and algorithms. The study finds that the primary intelligent techniques used in the field of textile colour management include artificial neural networks (ANN), support vector machines (SVM) such as SVM, LSSVM, LSSVR, SLSSVR, FWSVR, fuzzy logic (FL) and adaptive neuro-fuzzy inference systems (ANFIS), clustering algorithms (e.g., K-means, FCM, X-means algorithms), and extreme learning machines (ELM) such as ELM, OSLEM, KELM, RELM. The main optimization algorithms used include response surface methodology (RSM), genetic algorithms (GA), particle swarm optimization (PSO), and differential evolution (DE). Finally, the study proposes a comparison of the performance of intelligent techniques and optimization algorithms, summarizes the relevant research trends, and suggests future research opportunities and directions, besides stating the limitations of this paper.
Imageless robotic total knee arthroplasty determines similar coronal plane alignment of the knee (CPAK) parameters to long leg radiographs
Authors: Edelstein Adam I. , Orsi Alexander D. , Plaskos Christopher , Coffey Simon , Suleiman Linda I. 
Published: March 2024

Abstract
Background
The coronal plane alignment of the knee (CPAK) classification was first developed using long leg radiographs (LLR) and has since been reported using image-based and imageless robotic total knee arthroplasty (TKA) systems. However, the correspondence between imageless robotics and LLR-derived CPAK parameters has yet to be investigated. This study therefore examined the differences in CPAK parameters determined with LLR and imageless robotic navigation using either generic or optimized cartilage wear assumptions.

Methods
Medial proximal tibial angle (MPTA) and lateral distal femoral angle (LDFA) were determined from the intraoperative registration data of 61 imageless robotic TKAs using either a generic 2 mm literature-based wear assumption (Navlit) or an optimized wear assumption (Navopt) found using an error minimization algorithm. MPTA and LDFA were also measured from preoperative LLR by two observers and intraclass correlation coefficients (ICCs) were calculated. MPTA, LDFA, joint line obliquity (JLO), and arithmetic hip-knee-ankle angle (aHKA) were compared between the robotic and the average LLR measurements over the two observers.

Results
ICCs between observers for LLR were over 0.95 for MPTA, LDFA, JLO, and aHKA, indicating excellent agreement. Mean CPAK differences were not significant between LLR and Navlit (all differences within 0.6°, P > 0.1) or Navopt (all within 0.1°, P > 0.83). Mean absolute errors (MAE) between LLR and Navlit were: LDFA = 1.4°, MPTA = 2.0°, JLO = 2.1°, and aHKA = 2.7°. Compared to LLR, the generic wear classified 88% and the optimized wear classified 94% of knees within one CPAK group. Bland–Altman comparisons reported good agreement for LLR vs. Navlit and Navopt, with > 95% and > 91.8% of measurements within the limits of agreement across all CPAK parameters, respectively.

Conclusions
Imageless robotic navigation data can be used to calculate CPAK parameters for arthritic knees undergoing TKA with good agreement to LLR. Generic wear assumptions determined MPTA and LDFA with MAE within 2° and optimizing wear assumptions showed negligible improvement.
Use of a fractional dose of inactivated polio vaccine (fIPV) to increase IPV coverage among children under 5 years of age in Somalia
Authors: Nouh Khaliif , Haga Abdirizak , Sumaili Kyandindi , Farid Muhammad , Alin Mohamed , Shube Mukhtar , Abshir Abdirizak , Hiirad Mohamed , Ahmed Muhyadeen , Bile Ahmed 
Published: March 2024

Abstract
Background
Global efforts reduced incidence of polio cases from 350,000 in 1988 to 22 cases in 2022 globally. There have been no wild poliovirus (WPV) cases seen in Somalia since August 2014. However, in 2017, there was a surge in the number of cases of circulating vaccine-derived poliovirus type 2 (cVDPV2), even with different intervention responses using monovalent oral polio vaccine type 2 (mOPV2). This study aimed to assess the use of fractional inactivated polio vaccine (fIPV), a smaller dose of the polio vaccine, equal to 1/5 of a standard dose, as an innovative polio vaccination delivery model, and identify the main opportunities for and challenges to the use of fIPV in the future for vaccinations.

Methods
The study used two designs: a quasi-experimental design used to pilot fIPV in five districts and a cross-sectional study using both quantitative and qualitative approaches to collect primary data. A simple random sampling method was used to select 2 out of the 5 pilot districts for household surveys to study 768 participants. Key informant interviews and focus-group discussions were used to collect data from key frontline health workers and health/immunization officials involved in the campaigns. Secondary data from the pilot campaigns were analysed, such as administrative pilot data, lot quality assurance sampling (LQAS) and post-campaign communication assessments.

Results
A total of 131,789 children aged 4–59 months were included for the pilot. Among these, 126,659 (96.1%) and 126,063 (95.6%) children were vaccinated in rounds 1 and 2, respectively. Out of the 768 households assessed, 99.9% had their children vaccinated. Nearly half of the few children who were not vaccinated were reported to be due to the parent of the child not being at home (48%). Ninety-seven percent of the qualitative study interviewees were satisfied with fIPV injection and recommended its use for routine immunization.

Conclusions
The study findings are promising in the use of fIPV in mass campaigns to realize better coverage and global polio eradication. fIPV will potentially be used by policymakers in the design of polio eradication campaigns that integrate the fIPV vaccine into routine or supplementary immunization.
Association of Intravenous Neostigmine and Anticholinergics or Sugammadex with Postoperative Delirium: A Retrospective Cohort Study
Authors: Rössler Julian , Abramczyk Emily , Paredes Stephania , Anusic Nikola , Pu Xuan , Maheshwari Kamal , Turan Alparslan , Ruetzler Kurt 
Published: March 2024

BACKGROUND:
Administration of cholinesterase inhibitors in combination with anticholinergic drugs for reversal of neuromuscular blocks may precipitate delirium through impairment of central cholinergic transmission, which could be avoided by using sugammadex. Therefore, we tested the primary hypothesis that postoperative delirium is less common when neuromuscular block is reversed with sugammadex than with neostigmine combined with glycopyrrolate or atropine.

METHODS:
We conducted a single-center retrospective cohort study, analyzing all adult patients having general anesthesia for noncardiac surgery who received neostigmine or sugammadex from January 2016 to March 2022. Inverse propensity score weighting and propensity score calibration were used to adjust for appropriate confounders. Our primary outcome was presence of delirium within the first 4 days after surgery, defined as at least 1 positive brief Confusion Assessment Method (bCAM) screening. The secondary outcome was the presence of early delirium within 24 hours of surgery.

RESULTS:
Among 49,468 cases in our analysis, 6881 received sugammadex and 42,587 received neostigmine. After propensity weighting, the incidence of delirium was 1.09% in the sugammadex group and 0.82% in the neostigmine group. The odds of postoperative delirium did not differ between the sugammadex and neostigmine groups, with an estimated odds ratio (95% confidence interval) of 1.33 (0.91–1.95), P = .147. A sensitivity analysis restricted to only include cases with at least 6 bCAM measurements over postoperative day (POD) 1 to 4 had consistent results, as sugammadex compared with neostigmine was associated with an estimated odds ratio for postoperative delirium of 1.20 (0.82–1.77), P = .346. Sugammadex was significantly associated with an increased incidence of early postoperative delirium, with an estimated odds ratio of 1.71 (1.07–2.72), P = .025. Further analysis showed no treatment-by-age interaction for either postoperative delirium (P = .637) or postoperative early delirium (P = .904).

CONCLUSIONS:
Compared to neostigmine, use of sugammadex for reversal of neuromuscular block was not associated with an increased risk of postoperative delirium in this retrospective single-center study. Though sugammadex was associated with a statistically significant increased risk of postoperative early delirium, the difference was small and not clinically relevant, and may reflect the presence of unknown confounders.
Bielefeld Game Theory and Indiana Institutional Analysis: Elinor Ostrom and Theories of Common-Pool Resources
Authors: Erickson Paul 
Published: March 2024

Abstract
This article explores the place of game theory in Elinor Ostrom's groundbreaking studies of nonmarket institutions for managing common-pool resources (CPRs) from the 1980s onward. While game theory had been associated with the study of CPRs since at least the later 1960s, the precise way scholars used the theory varied, depending not only on their home discipline but on the locally specific research program they hoped to develop. Ostrom's use of game theory ultimately looked quite different from that of laboratory psychologists studying “commons dilemmas,” political scientists theorizing about constitutional choice, or economists building formal models of sparse markets, bearing perhaps the closest resemblance to the economist Reinhard Selten's skeptical and heterodox applications of game theory to the study of industrial organization. This account of Ostrom's local adaptation of game theory potentially helps us evaluate critiques of her work that focus on her use of rational choice models.
Hotelling and Wilson on Statistical Inference: Local Attitudes and Universal Dreams
Authors: Carvajalino Juan , Mueller Thomas Michael 
Published: March 2024

Abstract
During the early 1920s, a scattered group of American scholars, among whom were Harold Hotelling and E. B. Wilson, started a joint effort to develop statistical instruments in economics. They became interested in disparate topics such as the statistical determination of demand curves, business cycles, yield forecasting, population growth, and many others. Hotelling and Wilson shared much: both were trained in mathematics, both were convinced of the importance of developing inferential statistical tools based on probability theory, and both were at odds with the common sentiment of the community of statisticians contemporary with them, a community that was highly skeptical about statistical inference grounded on probabilities. Their trajectories, however, differed, diverted by their entanglement with Stanford for Hotelling and Harvard for Wilson. Confronted with different local realities, they came to develop profoundly different approaches that characterized the debates of the 1920s and 1930s on statistical inference.
Setting the Stage for Disciplinary Transformations: Riker, McKenzie, and the Case of the University of Rochester
Authors: Damiani Gianluca 
Published: March 2024

Abstract
This article offers a historical reconstruction of the birth and shaping of two research communities at the University of Rochester, that of economists and that of political scientists. Starting from the late 1950s, the arrival at Rochester of the renowned mathematical economist Lionel W. McKenzie and, later, of the innovative political scientist William H. Riker transformed this university into a leading research institution in economics and political science. The simultaneous presence of Riker and McKenzie at Rochester introduces a “local dimension” in this story, especially since Riker's aim was to convert political science into a theory-driven, highly formal discipline, which he labeled “positive political theory,” apparently along similar lines as the postwar mathematical revolution in economics, of which McKenzie was one of the main characters. This article tries to assess the existence, direction, and effects of this “local” element in the case of Rochester.
Sustained effects of developmental exposure to inorganic arsenic on hepatic gsto2 expression and mating success in zebrafish
Authors: Koomson Abigail Ama , Delaney Patrice , Khan Nouf , Sadler Kirsten C. 
Published: March 2024

ABSTRACT
The impacts of exposure to the pervasive environmental toxicant, inorganic arsenic (iAs), on human and fish health are well characterized and several lines of evidence suggest that some impacts can manifest years after exposure cessation. Using a developmental exposure protocol whereby zebrafish embryos were exposed to 0.5 and 1.5 mM iAs from 4–120 hours post fertilization (hpf) and then removed, we investigated the sustained effects of iAs on gene expression in the liver, survival, reproductive success, and susceptibility to iAs toxicity in the subsequent generation. Persistent exposure to iAs during development had substantial effects on the hepatic transcriptome, with 23% of all expressed genes significantly changed following developmental exposure. The gsto2 gene is involved in iAs metabolism and this gene was significantly downregulated in female livers 9 months after iAs was removed. Developmental exposure to 1.5 mM iAs, but not 0.5 mM, decreased survival by over 50% at 3 months of age. Adults that were developmentally exposed to 0.5 mM iAs had reduced mating success, but their offspring had no differences in observable aspects of development or their susceptibility to iAs toxicity. This demonstrates that developmental exposure of zebrafish to iAs reduces long-term survival, reproductive success and causes sustained changes to gsto2 expression in the liver.
The experiences of patients using a cancer hotline service
Authors: Baksh Farzana , Carvalho Filipe 
Published: March 2024

Background: The present study aimed to evaluate oncology patients' experiences with a hotline service in a tertiary cancer centre, identifying areas for local improvement and to inform the work of the hotline. Methods: A link to an online platform to complete a survey was sent through bulk messaging to 3028 mobile numbers. The survey answers and results were saved and consolidated in the online platform. Findings: The survey received 368 responses: 49% of participants had their calls answered within 10 minutes, while 18% (n=66) waited 30 minutes or more. Eighty-two per cent were satisfied with the length of time they waited to speak with a nurse and 71% reported that their overall experience was very good. Ninety-seven per cent of participants felt listened to and were offered support and 91% felt that their reason for calling was adequately addressed. Conclusion: The present study offers persuasive evidence indicating that oncology patients are largely satisfied with the hotline service; nonetheless, it is recognised that a more robust evaluation is needed. Regardless, the need for certain improvements has been identified to offer the potential to enhance patients' experience.
The Relationship between Autism Spectrum Disorder among Children and Perceived Functioning among Parents in Italy
Authors: Vitale Elsa , Trevisi Francesca , Lezzi Alessia , Zacchino Simone , Valenzano Laura , Caldararo Cosimo , D’Amanzo Erika , Benedetto Angelo , Petrelli Cosimo , Cucci Federico , Calabrò Antonino , Latina Salvatore , Lupo Roberto 
Published: March 2024

Aim: To evaluate how the life of a parent changes from a psychological, social and economic point of view and to investigate levels of anxiety and depression perceived from the moment of diagnosis of the child's Autism Spectrum Disorder (ASD).
Methods: From March to December 2021 an observational, cross sectional multicentre study was conducted.
Results: A total of 372 parents were recruited in this survey. From data collected, most of parents reported high depression than anxiety levels. Parents interviewed declared that in most of the life spheres, such as: social, working, family, the presence of their sons with ADS have importantly influenced their lives. No significant associations were recorded between the autistic child habits or behaviors and the presence of anxiety among participants. On the other hand, motor and vocalist which could create serious disturbance among neighborhood was significantly associated with depression condition (p=0.021).
Conclusions: It has been shown that social, psychological and economic support from institutions and professionals is still very low.
Perovskite quantum laser with enhanced population inversion driven by plasmon-induced hot electron transfer under potential shift polarization conditions
Authors: Pan Yong , Wu Lijie , Zhang Yuan , Zhang Yihao , Xu Jie , Xie Haixia , Cao Jianguo 
Published: March 2024

The hot electron transfer resulting in fluorescence enhancement is significantly meaningful for theory and experiment of the study on photoelectric devices. However, the laser emission based on direct hot electron transfer is difficult to realize because of the low transfer efficiency. To achieve a laser with a new-generation mechanism based on hot electron transfer, the photoelectric co-excitation is proposed for improving the efficiency of hot electron transfer. The lasing behavior at 532 nm is realized with a threshold of 5  kw cm−2 and 1 μA, which can be considered as the hot electron transfer resulting in population inversion enhancement. Meanwhile, the lasing output power is 0.3 mW. The hot electrons transfer process was described via the transient absorption spectrum according to the improved ground-state bleaching and excited-state absorption signal in device ON. Through comparison with the optical pump only, the quantum efficiencies of hot electron generation (HEG) and hot electron transfer (HET) were increased ∼31% and 31%, respectively. Most importantly, a triple gain mode coupling device including local surface plasmon, hot electron transfer, and array oscillation was presented. Two modes of population inversion enhancement are proposed. This study can provide theoretical and experimental reference for the research of hot electron lasers and devices.