bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indicators describing the tumor lesion aggregation and dissemination and their impact on the prognosis of patients with diffuse large B cell lymphoma receiving chimeric antigen receptor T cell therapy
Authors: Dang Xiuyong , Li Ping , Shen Aijun , Lu Yan , Zhu Zeyu , Zhang Min , Qian Wenbin , Liang Aibin , Zhang Wenjun 
Published: March 2024

AbstractIntroductionChimeric antigen receptor (CAR) T cell therapy has markedly improved the prognosis of patients with diffuse large B‐cell lymphoma (DLBCL). The relative positioning of tumor lesions in lymphoma varies among patients, manifesting as either aggregation (clumped together) or dissemination (spread throughout the body). Prognostic significance of factors indicating the relative positioning of tumor lesions in CAR T cell therapy remains underexplored. For aggregation, prior research proposed the tumor volume surface ratio (TVSR), linking it to prognosis in chemotherapy. Regarding dissemination, indicators such as disease stage or extranodal involvement, commonly used in clinical practice, have not demonstrated prognostic significance in CAR T cell therapy. This study aims to analyze current indicators of tumor aggregation or dissemination and introduce a novel indicator to assess the prognostic value of tumor lesions' relative positioning in DLBCL patients undergoing CAR T cell therapy.MethodsThis retrospective study included 42 patients receiving CAR T cell therapy. Lesion image information was obtained from the last PET/CT scan prior to CAR T cell infusion, including total metabolic tumor volume, total tumor surface, diameter of lymphoma masses, and the sites of tumor lesions. We evaluated TVSR and bulky disease as descriptors of tumor aggregation. We refined existing indicators, stage III&IV and >1 site extranodal involvement, to distill a new indicator, termed ‘extra stage’, to better represent tumor dissemination. The study examined the prognostic significance of tumor aggregation and dissemination.ResultsOur findings indicate that TVSR, while prognostically valuable in chemotherapy, lacks practical prognostic value in CAR T cell therapy. Conversely, bulky disease emerged as an optimal prognostic indicator of tumor aggregation. Both bulky disease and extra stage were associated with poor prognosis and exhibiting synergistic prognostic impact in CAR T cell therapy.ConclusionsOverall, the relative positioning of tumor lesions significantly influences the prognosis of patients with DLBCL receiving CAR T cell therapy. The ideal scenario involves tumors with minimal dissemination and no aggregation.
Body composition change indices combined with Prognostic Nutritional Index predicts the clinical outcomes of patients with gastric cancer treated with immune checkpoint inhibitor
Authors: Deng Guiming , Zhu Dayong , Du Zhongze , Xue Yingwei , Song Hongjiang , Li Yuanzhou 
Published: March 2024

AbstractObjectiveThis study aimed to investigate the prognostic significance of the Prognostic Nutritional Index (PNI) in conjunction with body composition change indices, namely subcutaneous fat area (SFA) and skeletal muscle index (SMI), with regard to clinical outcomes in patients with gastric cancer (GC) undergoing immune checkpoint inhibitors (ICIs) treatment.MethodsThis retrospective investigation encompassed patients with comprehensive clinical and pathological data, inclusive of portal phase enhanced CT images. Continuous variables underwent analysis utilizing the Student t‐test or Mann–Whitney U‐test, while categorical variables were assessed employing the Pearson chi‐squared test or Fisher test. Survival outcomes were evaluated using Kaplan–Meier survival curves and the Log‐rank test. Independent prognostic indicators were determined through Cox regression analysis, and a nomogram predicting survival probability for progression‐free survival (PFS) and overall survival (OS) was constructed.ResultsWithin the PNI‐SFA groups, patients in Group 1 exhibited inferior PFS and OS compared to the other two groups. Similarly, among the PNI‐SMI groups, Group 1 patients demonstrated poorer PFS and OS. PNI‐SMI and Eosi were identified as independent prognostic factors through Cox regression analysis. Furthermore, positive associations with patient prognosis were observed for BMI, SAF, SMI, and PNI.ConclusionThe comprehensive consideration of PNI‐SFA and PNI‐SMI proved to be a superior prognostic predictor for GC patients undergoing ICI treatment.
Pharmacological Activities of Plant‐Derived Fraxin with Molecular Mechanisms: A Comprehensive Review
Authors: Ferdous Jannatul , Bhuia Md. Shimul , Chowdhury Raihan , Rakib Asraful Islam , Aktar Mst. Asma , Al Hasan Md. Sakib , Melo Coutinho Henrique Douglas , Islam Muhammad Torequl 
Published: March 2024

AbstractFruits and vegetables serve not only as sources of nutrition but also as medicinal agents for the treatment of diverse diseases and maladies. These dietary components are significant resources of phytochemicals that demonstrate therapeutic properties against many illnesses. Fraxin is a naturally occurring coumarin glycoside mainly present in various species of Fraxinus genera, having a multitude of therapeutic uses against various diseases and disorders. This study focuses to investigate the pharmacological activities, botanical sources, and biopharmaceutical profile of the phytochemical fraxin based on different preclinical and non‐clinical studies to show the scientific evidence and to evaluate the underlying molecular mechanisms of the therapeutic effects against various ailments. For this, data was searched and collected (as of February 15, 2024) in a variety of credible electronic databases, including PubMed/Medline, Scopus, Springer Link, ScienceDirect, Wiley Online, Web of Science, and Google Scholar. The findings demonstrated favorable outcomes in relation to a range of diseases or medical conditions, including inflammation, neurodegenerative disorders such as cerebral ischemia‐reperfusion (I/R) and depression, viral infection, as well as diabetic nephropathy. The phytochemical also showed protective effects such as osteoprotective, renoprotective, pulmoprotective, hepatoprotective, and gastroprotective effects due to its antioxidant capacity. Fraxin has a great capability to diminish oxidative stress‐related damage in different organs by stimulating the antioxidant enzymes, downregulating nuclear factor kappa B and NLRP3, and triggering the Nrf2/ARE signaling pathways. Fraxin exhibited poor oral bioavailability because of reduced absorption and a wide distribution into tissues of different organs. However, extensive research is required to decipher the biopharmaceutical profiles, and clinical studies are necessary to establish the efficacy of the natural compound as a reliable therapeutic agent.
Ameliorative Effect of Morinda Officinalis Oligosaccharides on LPS‐Induced Acute Lung Injury
Authors: Qing Cheng , Wu Yanrong , Liu Binbin , Wang Cheng , Zeng Zhenguo 
Published: March 2024

AbstractAcute lung injury (ALI) is a disease characterized by extensive lung damage and rampant inflammation, with a high mortality rate and no effective treatments available. Morinda officinalis oligosaccharides (MOOs), derived from the root of the traditional Chinese medicinal herb Morinda officinalis, known for its immune‐boosting properties, presents a novel therapeutic possibility. To date, the impact of MOOs on ALI has not been explored. Our study aimed to investigate the potential protective effects of MOOs against ALI and to uncover the underlying mechanisms through an integrated approach of network pharmacology, molecular docking, and experimental validation. We discovered that MOOs significantly mitigated the pathological damage and decreased the expression of pro‐inflammatory cytokines in LPS‐induced ALI in mice. Complementary in vitro studies further demonstrated that MOOs effectively attenuated the M1 polarization induced by LPS. Network pharmacology analysis identified HSP90AA1, HSP90AB1, and NF‐κB as key overlapping targets within a protein‐protein interaction (PPI) network. Furthermore, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses elucidated the biological processes and signaling pathways implicated in MOOs′ therapeutic action on ALI. Subsequently, molecular docking affirmed the binding of MOOs to the active sites of these identified targets. Corroborating these findings, our in vivo and in vitro experiments consistently demonstrated that MOOs significantly inhibited the LPS‐induced upregulation of HSP90 and NF‐κB. Collectively, these findings suggest that MOOs confer protection against ALI through a multi‐target, multi‐pathway mechanism, offering a promising new therapeutic strategy to mitigate this severe pulmonary condition.
Stereoselective Synthesis of the Gal‐α‐(1→3)‐Gal‐β‐(1→3)‐GlcNAc Trisaccharide: a new Ligand for DCAR and Mincle C‐Type Lectin Receptors
Authors: Tricomi Jacopo , Aoun Mike , Xu Bingze , Holmdahl Rikard , Richichi Barbara 
Published: March 2024

AbstractIn this work, we have discovered that the Gal‐α‐(1→3)‐Gal‐β‐(1→3)‐GlcNAc trisaccharide, a fragment of the B antigen Type‐1, is a new ligand of two C‐type lectin receptors (CLRs) i. e. DCAR and Mincle which are key players in different types of autoimmune diseases. Accordingly, we report here on a straightforward methodology to access pure Gal‐α‐(1→3)‐Gal‐β‐(1→3)‐GlcNAc trisaccharide. A spacer with a terminal primary amine group was included at the reducing end of the GlcNAc residue thus ensuring the further functionalization of the trisaccharide Gal‐α‐(1→3)‐Gal‐β‐(1→3)‐GlcNAc.
Advance of Single‐Atom Catalysts Confined into Pristine Metal‐Organic Frameworks and their Energy‐Related Applications
Authors: Mo Qijie , Chen Chunying , Li Sihong , Liu Jiewei , Zhang Li , Su Cheng‐Yong 
Published: March 2024

AbstractMetal single‐atom catalysts (SACs) play an essential role in small molecule related energy conversion. Metal‐organic frameworks (MOFs), which contain the highly ordered arrays of organic linkers and metal nodes, as well as the clearly defined pore structures, are considered as an ideal platform to fabricate atomically dispersed metal sites. In this review, we summarize the approaches for fabricating MOF‐based SACs by utilizing their structure characteristics. A brief discussion is also given about the feasible techniques to characterize SACs. A series of representative examples of MOF‐based SACs and their energy‐related applications, mainly in photocatalysis and electrocatalysis, are discussed. The challenges and future development opportunities of MOF‐based SACs are highlighted.
Driving inward growth of lithium metal in hollow microcapsule hosts by heteroatom‐controlled nucleation
Authors: Kim Siwon , Shin Hong Rim , Kim Ki Jae , Park Min‐Sik , Lee Jong‐Won 
Published: March 2024

AbstractThe application of Li metal anodes in rechargeable batteries is impeded by safety issues arising from the severe volume changes and formation of dendritic Li deposits. Three‐dimensional hollow carbon is receiving increasing attention as a host material capable of accommodating Li metal inside its cavity; however, uncontrollable and nonuniform deposition of Li remains a challenge. In this study, we synthesize metal–organic framework‐derived carbon microcapsules with heteroatom clusters (Zn and Ag) on the capsule walls and it is demonstrated that Ag‐assisted nucleation of Li metal alters the outward‐to‐inward growth in the microcapsule host. Zn‐incorporated microcapsules are prepared via chemical etching of zeolitic imidazole framework‐8 polyhedra and are subsequently decorated with Ag by a galvanic displacement reaction between Ag+ and metallic Zn. Galvanically introduced Ag significantly reduces the energy barrier and increases the reaction rate for Li nucleation in the microcapsule host upon Li plating. Through combined electrochemical, microstructural, and computational studies, we verify the beneficial role of Ag‐assisted Li nucleation in facilitating inward growth inside the cavity of the microcapsule host and, in turn, enhancing electrochemical performance. This study provides new insights into the design of reversible host materials for practical Li metal batteries.
Aerosol deposition and emission from a United States Pharmacopeia‐induction port when using a pressurized metered‐dose inhaler with and without a valved holding chamber
Authors: de Charras Yamila L. , Ramírez Rigo M. Verónica , Bertin Diego E. 
Published: March 2024

AbstractThe testing of pharmaceutical aerosols includes measuring the aerodynamic particle size distribution, which is usually performed on cascade impactors. In the next generation impactor (NGI), the aerosol dose is introduced through an induction port (IP), being separated into different aerodynamic diameter ranges by seven stages and a micro‐orifice collector. The IP plays an important role in estimating the oropharyngeal deposition fraction. While the IP retains mainly large particles, it also tends to retain particles in the respirable range. In this work, the deposition of particles in the IP of an NGI is studied, both experimentally and through computational fluid dynamic (CFD) simulations. Experimental tests are conducted both with the pressurized metered‐dose inhaler (pMDI) alone and in conjunction with a cylindrical valved holding chamber (VHC). For each case, the total mass deposition that occurs in the VHC, IP, and NGI stages is measured, as well as the mass median aerodynamic diameter of the aerosol leaving the IP. The CFD simulations show minimal variations in results regardless of the injection method due to the relatively low velocity and spray angle of the pMDI‐generated aerosol. If the flap‐valve is removed from the VHC, significant particle deposition occurs upstream or within the valve region, with downstream air recirculation contributing to small particle deposition. Based on the CFD results, a correlation is proposed to accurately predict the particle escape fraction of the IP and VHC, which allows estimation of the tannin distribution of particles collected in the NGI stages, especially those corresponding to the range of respirable particles.
Identification of prognostic factors and construction of nomogram to predict cancer‐specific survival for patients with ovarian granulosa cell tumors
Authors: Zhang Yue , Zhang Zhen , Ding Xinyao , Zhang Keyi , Dai Youren , Cheng Wenjun , Luo Chengyan 
Published: March 2024

AbstractBackgroundOvarian granulosa cell tumors (OGCTs) feature low incidence, indolent growth and late recurrence. Treatment for recurrent OGCTs is challenging.MethodsThe present study was designed to explore the prognostic factors and establish a nomogram to predict cancer‐specific survival (CSS) for OGCTs patients. Enrolled in the study were 1459 eligible patients in the Surveillance, Epidemiology, and End Results (SEER) database, who were randomized to the training (n = 1021) or testing set (n = 438) at a ratio of 7:3. Univariate and multivariate Cox regression analyses were employed to screen the prognostic factors. The predictors were determined by using the Least absolute shrinkage and selection operator (LASSO) regression analysis. The model was constructed via the Cox proportional hazards risk regression analysis. The performance and clinical value of the nomograms was assessed with C‐index, calibration plots, and decision curve analysis.ResultsAge, pTNM stage, tumor size, surgery of the primary tumor, surgery of regional lymph nodes (LNs), residual disease after surgery, and chemotherapy were considered as significant predictive factors for CSS in OGCTs patients. After screening, the prognostic factors except surgery of regional LNs and chemotherapy were employed to build the nomogram. With desirable discrimination and calibration, the nomogram was more powerful in predicting CSS than the American Joint Committee on Cancer staging system in clinical use.ConclusionThis novel prognostic nomogram, which comprises a stationary nomogram and a web‐based calculator, offers convenience for clinicians in personalized decision‐making including optimal treatment plans and prognosis assessments for OGCTs patients.
Genotypic variation in functional contributors to yield for a diverse collection of field‐grown cotton
Authors: Kaur Navneet , Snider John L. , Paterson Andrew H. , Virk Gurpreet , Parkash Ved , Roberts Phillip , Li Changying 
Published: March 2024

AbstractYield improvement in cotton could be accelerated through selection for functional yield drivers such as interception of cumulative photosynthetically active radiation (∑IPAR), radiation use efficiency (RUE), and harvest index (HI). However, information on the extent to which these traits vary in cotton in the southeastern United States is limited. It was hypothesized that functional yield drivers would vary significantly within a diverse cotton collection. This study was conducted in Tifton and Athens, GA, and included a total of 4 site‐years. Lint yield, total biomass production, ∑IPAR, RUE, and HI were all affected by genotype. Biomass was more strongly correlated with RUE than ∑IPAR. Even among the highest yielding genotypes, values for functional yield drivers (biomass and harvest index) differed significantly, indicating that high yields could be achieved by differentially manipulating these underlying traits. However, when considered for all genotypes, only HI exhibited a significant positive correlation with yield. Boll production and intra‐boll yield components were also affected by genotype. When considered across upland genotypes, lint per boll, lint per seed, and lint percent were strongly associated with HI and lint yield, whereas boll mass and seed number per boll were not. We conclude that the genotypes evaluated in the current study achieve high lint production per boll and lint yields by manipulating different yield drivers. However, lint yield was primarily maximized through an increase in HI due to increases in boll production and within‐boll distribution of biomass to fiber, not due to increases in total biomass production or boll size.
How does CEO ethical leadership transform Saudi SMEs into green firms? A moderated mediation model
Authors: Hameed Zahid , Naeem Rana Muhammad , Islam Tahir , Alshibani Safiya Mukhtar 
Published: March 2024

AbstractIn the aftermath of global warming, companies face huge pressure to minimize waste, reduce carbon emissions, and generally become more responsible in their operations. Against this backdrop, researchers argue that top management can significantly shape a firm's environmental performance (EP). This research aims to investigate the impact of CEO ethical leadership style on Saudi firms' EP in the presence of green human resource management (GHRM) practices as a mediator and stakeholder pressure as a moderator. We utilize the resource‐based view and stakeholder theory to develop hypotheses on these relationships. Multisourced data were collected from 272 small and medium‐sized manufacturing enterprises (SMEs) in Saudi Arabia. Our findings revealed that CEO ethical leadership positively influences firm EP via GHRM practices. The results also indicated that stakeholder pressure moderates the direct relationship between CEO ethical leadership and GHRM practices. Moreover, the stakeholder pressure moderates the indirect effect of CEO ethical leadership on firms' EP via GHRM. This study suggests that stakeholder pressure and GHRM practices are important mechanisms between CEO ethical leadership and firms' EP. Our research highlights essential theoretical and empirical contributions and provides insights for HR practitioners when and why SMEs engage in environment‐friendly practices.
An economical and simple strategy for overcoming the Hall sensor faults in three phase brushless DC motor drive
Authors: Verma Mriduwani , Mitra Arghya , Bhat Sunil , Garain Kanchan , Pal Saumitra , Wankhede A. K. 
Published: March 2024

SummaryBrushless DC motors (BLDCs) are highly efficient and have the least maintenance requirement due to which they have replaced many conventional AC motors in various applications like electric vehicles, fans, water pumps, and home appliances. However, like all conventional motors, performance degradation of the BLDC motors can occur due to faults like Hall sensors failure, commutation switch failure, and stator‐winding failure. Among all these failures, this paper focuses on Hall sensor failures and the execution of fault tolerant control. Hall sensors produce an output after every 60° of rotation of the rotor, generating six sequences in one electrical cycle. In this study, each sequence is defined as a sector, which corresponds to the rotor position. Based only on this sector information in each electrical cycle, this paper proposes an uncomplicated detection strategy for Hall sensor fault, which is independent of motor loading and high‐performance processing unit. Along with the diagnosis, an improved faulty signal reconstruction is implemented, which bypasses the fault and continues a smooth performance of the motor. The proposed detection and reconstruction strategies have been simulated in MATLAB Simulink 2020, and the experimental analysis has been conducted to validate the proposed strategies.
Close to practice research as a means of rethinking elements of student–teacher's classroom practice
Authors: Blackmore Karen , Hatley Jenny 
Published: March 2024

AbstractThis article explores a form of classroom inquiry linked to postgraduate primary student–teachers’ education, whilst on practicum in England. The inquiry model is congruent with Stenhouse's’ notions of ‘teachers as researchers’ undertaking ‘systematic’ inquiry in a ‘naturalistic’ environment. Feldman further develops Stenhouse's conception into a definition of action research, where teachers come to a better understanding of their practice. The inquiry bases itself on the central tenants of close to practice (CtP), which is defined as research that: focuses on issues defined by practitioners as relevant to their practice and involves collaboration between people whose main expertise is research, practice, or both. As teacher educators, we evaluated the potential of CtP inquiry, by undertaking a critical discourse analysis (CDA) of sixteen student–teacher research reports. CDA revealed that several socio‐cognitive processes took place as a result of, student–teachers engaging in CtP research, including explorations of identity, beliefs and values and negotiation of power relationships and structures. Further analysis provided insights into Stenhouses' conceptualisation, firstly, how student–teachers committed to developing their understanding of the curriculum with respect to teaching design. Secondly, the findings resonate with student–teachers rejecting acting as ‘docile agents’ within existing structures and developing ‘pathways to emancipation and autonomy’. Thirdly, testimony revealed that student–teachers valued this mode of learning and developed critical attitudes to educational research. This study has clear implications for the design of initial teacher education programs and the continued professional development of teachers in England and potentially further afield.