bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of GABA and Insulin Regulated Aminopeptidase on Insulin Resistance and GLUT4 in Prediabetes and Type 2 Diabetes Mellitus
Authors: Khashan Ismael Sadeq , Majeed Maysaa Jalal 
Published: April 2024

Background: Different proposed mechanisms for insulin resistance have been put forth to understand the relationship and changes in insulin resistance. Looking at the levels of insulin, the neurotransmitter gamma-aminobutyric acid, glucose transport type 4, and the newly discovered enzyme insulin regulated aminopeptidase may provide an integrated perspective on insulin resistance.
Objectives: To study the role of serum gamma-aminobutyric acid and insulin regulated aminopeptidase enzyme levels in pathogenesis of insulin resistance and translocation of glucose transport type 4 in patients with type2 diabetes mellitus and pre-diabetes ones.
Subjects and methods: Ninety individuals were divided into three age- and BMI matched groups (diabetics, prediabetics, healthy) were assessed for glycated hemoglobin (turbidometry method), fasting serum glucose (colorimetric method), serum insulin (electrochemiluminescence immunoassay method), homeostatic model assessment for insulin resistance, serum gamma-aminobutyric acid, glucose transporter type 4, and insulin regulated aminopeptidase measured by the sandwich ELISA method. The cut-off value was adopted according to the World Health Organization, individuals with their fasting serum glucose lower than 110 mg/ml, and glycated hemoglobin level not more than 5.7 % are considered healthy individuals.
Result: The mean (±SD) values of serum insulin regulated aminopeptidase, gamma-aminobutyric acid and glucose transport type 4 showed significantly lower levels with greater increases in insulin resistance, represented by the significant decrease in diabetics group who have high insulin resistance compared with pre-diabetics and healthy individuals’ groups (p < 0.05). They also significantly decrease in individuals with the pre-diabetic stage compared to healthy individuals without insulin resistance (p < 0.05). Significant negative correlations were found between HOMA-IR values and each of GABA, IRAP, and GLUT4.
Conclusion: Decreasing gamma-aminobutyric acid may promote insulin resistance and prediabetes/diabetes onset. Decreased insulin regulated aminopeptidase levels suggest a role alongside glucose transport type 4 in glucose uptake, allowing screening for prediabetes risk.
Concientización sobre la obesidad en Latinoamérica en los centros de salud utilizando un árbol de decisión
Authors: Chuctaya Ruiz Diego Moises , Condori Villalba Luis Pablo , Ramos Ticona Gilbert Wil , Santos Adilson Esteba Cruz 
Published: April 2024

El presente documento busca concientizar acerca de la obesidad localizada en Latinoamérica y sus centros de salud, incitando a reducir la obesidad en la población, tomando como herramienta un software que a partir de los datos tomados en la investigación pueda determinar los niveles de obesidad en un paciente utilizando técnicas relacionadas a la Inteligencia Artificial donde el modelo aplicado a los datos se puede observar cuales son las personas con un mayor grado de obesidad y analizar sus respectivas causas.
STUDI EMPIRIS RISIKO OPERASIONAL SISTEM MANAJEMEN K3 TERHADAP TINDAKAN TIDAK AMAN (UNSAFE ACTION) PADA INDUSTRI MARITIM
Authors: Winarni Endra 
Published: April 2024

Abstrak
Wilayah Sub Holding Multi Terminal memiliki daerah kerja cukup luas yang sebagian besar kegiatannya berhubungan dengan alat berat yang berisiko. Kegiatan operasional kapal dan bongkar muat beberapa tahun terakhir semakin meningkat dan mengakibatkan banyaknya risiko yang terjadi. Di lapangan masih diketemukan banyaknya risiko karena meningkatnya kegiatan bongkar maupun muat container ke moda transportasi lain, perpindahan container dari dan ke lapangan penumpukan atau gudang dan operasional kapal seperti aktivitas kapal labuh, kapal sandar. Selain itu, risiko yang mengakibatkan kecelakaan kerja karena minimnya kesadaran pekerja untuk mentaati peraturan dan prosedur keselamatan seperti menggunakan alat pelindung diri pada saat bekerja, juga minimnya kesadaran pada posisi kerja yang tidak aman (unsafe action). Tujuan penelitian ini mengidentifilasi faktor-faktor yang mempengaruhi risiko operasional, menilai risiko yang diakibatkan, tindakan pengendalian dalam mengurangi risiko dan mengetahui pengaruh variabel sistem manajemen K3 terhadap tidakan tidak aman (unsafe action) pada industri maritim di Indonesia. Metode penelitian yang digunakan adalah metode kombinasi desain concurrent embedded design. Pada penelitian ini faktor yang berpengaruh terhadap risiko operasional yang timbul dalam penerapan SMK3 pada industri maritim antara lain faktor penyebab dasar, faktor penyebab tidak langsung yang disebabkan faktor pekerjaan dan faktor personil, faktor penyebab langsung kecelakaan kerja dari kondisi tidak aman/ berbahaya (unsafe condition) dan tindakan tidak aman (unsafe action). Memiliki tingkat risiko tinggi pada kinerja bongkar muat yang tidak efektif dan efisien. Terdapat pengaruh negatif antara SMK3 terhadap tindakan tidak aman pada industri maritim yang ditunjukkan dengan nilai t hitung sebesar 7,453 lebih besar dari 1,63 dan nilai signifikansi 0.0000 lebih kecil dari 0,05.
Kata kunci: Risiko Operasional, Keselamatan dan Kesehatan Kerja, SMK3, Unsafe Action
Discerning the Holy Spirit in the World of Religious Pluralism(s), Secularism(s), and Science(s): A Multilayered Constructive Christian Vision of Pneumatology for the Third Millennium
Authors: Kärkkäinen Veli-Matti 
Published: April 2024

Abstract
This essay seeks to reimagine Christian pneumatology in a radically new key. This plural and multilayered vision allows us to discern the presence and work of the Spirit of God in the cosmos, in the secular and religiously pluralistic world and society, as well as in Christian life at both the ecclesial and personal levels. No need to mention that this kind of authentically Christian reimagining can only be accomplished in an integral trinitarian framework. This plural paradigm engages critically spiritual “powers” and energies (as in traditional “angelology”), the S/spirit(s) in other religions, the spirit(s) of the public realm (as in sciences, politics, and economy), and the spiritual aspects of (post-)secularism. And in difference from the traditional limited conception of the Spirit’s work to the “spiritual,” the multilayered and complex account of pneumatology seeks to envision the Spirit’s work in all aspects of the world and life.
RECURSOS DIDÁTICOS UTILIZADOS POR PROFESSORES DE CIÊNCIAS DA REDE PÚBLICA DE ANÁPOLIS-GO E O SEU CONHECIMENTO SOBRE OS MIXOMICETOS
Authors: Araújo Jéssica Conceição , Xavier-Santos Solange , Paulo Pedro Oliveira 
Published: April 2024

Recursos didáticos são materiais utilizados como auxílio no processo de ensino-aprendizagem pelo professor junto a seus alunos. Entre suas funções básicas, destacam-se a influência motivacional nos estudantes, a capacidade de atuar como mediador do conhecimento e, consequentemente, facilitador do processo de ensino-aprendizagem. Organismos modelos são seres vivos com características particulares e têm sido utilizados como importantes ferramentas de estudos para pesquisas em várias áreas, inclusive a Educação. Classificados no Reino Protozoa, Filo Amoebozoa, os mixomicetos compreendem um grupo de seres vivos que apresentam características peculiares, tanto em seu aspecto morfológico quanto fisiológico, sendo considerados organismos modelo para a representação de diversos fenômenos biológicos. Tendo em vista esse cenário, este trabalho teve por objetivo investigar os recursos didáticos utilizados por professores de Ciências do Ensino Fundamental de dez escolas públicas de Anápolis-GO, bem como seu conhecimento sobre os mixomicetos. Os dados foram obtidos por meio de questionários aplicados a um grupo de 14 professores de Ciências e foram analisados de forma quali-quantitativa. Foi verificado que os recursos didáticos mais utilizados pelos professores são o quadro/lousa, o projetor de multimídia e o livro didático. Os conhecimentos destes profissionais acerca dos mixomicetos foram considerados rasos, revelando concepções equivocadas e incompletas. Destacamos que seres vivos com potencial como ferramenta educacional, como é o caso dos mixomicetos, devem ser explorados para este propósito, principalmente com a realização de trabalhos voltados ao desenvolvimento de recursos didáticos que sejam acessíveis e apresentem amplas possibilidades de uso, principalmente para os professores dos anos finais do Ensino Fundamental da Educação Básica.
PENGARUH KOMITMEN ORGANISASI, KEPUASAN KERJA DAN KARAKTERISTIK INDIVIDU TERHADAP TURNOVER INTENTION PADA UPT DEPOGERBONG BESAR A SIMPANG PT. KAI DIVRE III KOTA PALEMBANG
Authors: N Maya Amelia , Aktarina Destia , Carolina Debi 
Published: April 2024

Turnover intention adalah kadar atau intensitas dari keinginan untuk keluar dari perusahaan, banyak alasan yang menyebabkan timbulnya turnover intention ini dan diantaranya adalah keinginan untuk mendapatkan pekerjaan yang lebih baik. Salah satu bentuk perilaku karyawan tersebut adalah turnover intention yang berujung pada keputusan karyawan pindah kerja. Turnover intention ditandai oleh berbagai hal yang berkaitan dengan komitmen organisasi, kepuasan kerja dan karakteristik individu. Tujuan dalam penelitian ini adalah untuk melihat perkembangan Komitmen Organisasi, Kepuasan Kerja, Karakteristik Individu Dan Turnover Intention pada UPT Depo Gerbong Besar A Simpang PT. Kai Divre III Kota Palembang. Untuk melihat pengaruh secara parsial Komitmen Organisasi, Kepuasan Kerja, Karakteristik Individu terhadap Turnover Intention pada UPT Depo Gerbong Besar A Simpang PT. Kai Divre III Kota Palembang dan secara simultan. Sampel yang di ambil sebanyak 40 karywan dengan menggunakan teknik purposive sampling. Penelitian ini menggunakan metode penelitian kuantitatif. Metode analisis data yang digunakan metode deskriptif dan verifikatif. Berdasarkan hasil pengujian secara parsial didapat kesimpulan bahwa komitmen organisasi, kepuasan kerja, karakteristik individu berpengaruh terhadap turnover intention dan hasil pengujian secara silmutan didapat kesimpulan bahwa minimal ada satu variabel bebas yang berpengaruh terhadap turnover intention
Examining Barriers and Perceptions in Reporting Medication Administration Errors among Nurses at the Tertiary Care Hospitals in Peshawar Pakistan
Authors: Anwar Muhammad , Muhammad Dildar , Shah Bakhtayar Ali , Shah Sumayya , Ullah Asad , Bibi Sumaira 
Published: April 2024

Medication administration is vital for patient safety, yet medication errors can lead to life-threatening situations and increased mortality rates. Nurses, being essential members of the healthcare team, are constantly present with patients and regularly tasked with drug administration, facing a significant burden of medication errors compared to other healthcare providers. Objectives: To explore the barriers and perceptions of nurses' regarding medication errors reporting in public sector tertiary care hospitals. Methods: A convenient sample of 209 staff nurses participated in this cross-sectional survey from June to October 2022. A three-part questionnaire was used to gather information on the general characteristics of nurses, the causes of medication errors, and the justifications for not reporting them. Results: The Pharmacy supplies inappropriate doses to this unit with a mean of (2.53 ± 1.28) and an insufficient number of staff nurses in each working shift (4.23 ± 0.76) were the two least and most significant contributing factors to medication errors. Additionally, the two most and least significant factors for not reporting medication errors were that nurses may be held accountable if the patient suffered harm (3.94 ± 1.16) and that nurses did not agree with the hospital's definition of a medication error (2.33 ± 1.26) on average. Conclusions: The main causes of drug mistakes and failure to reveal them were nursing and management issues. Moreover, attempt to establish a blame-free culture to motivate reporting errors.
Comparison Between Efficacy of Serial Glycolic Acid Peel with Modified Kligman’s Regimen Vs Modified Kligman’s Regimen Alone in Epidermal Melasma
Authors: Akhtar Nadia , Hassan Tahir , Shahzad Muhammad Khurram , Aliya Naima , Yousaf Sumera , Anwar Madiha 
Published: April 2024

The background of melasma involves its psychological impact and multifactorial etiology, encompassing genetic, hormonal, and environmental factors. Management strategies include sun protection and targeted treatments like glycolic acid peels and the modified Kligman's regimen to mitigate hyperpigmentation. Objective: To compare the clinical outcome specifically in terms of MASI score in epidermal melasma patients treated with the Modified Kligman's regimen alone versus combined with 35% Glycolic acid peels. Methods: In this randomized controlled trial, a total of 90 patients of epidermal melasma (with MASI score over 10) aged 18-55 years, visiting out-patient Dermatology department of Sheikh Zayed Hospital, Rahim Yar Khan were enrolled via non-probability consecutive sampling. The patients were divided into two groups (group A and group B), each having 45 patients. Patients in group A received the Modified Kligman's regimen (hydroquinone 4%, 0.05% tretinoin, and fluocinolone acetonide 0.01%), and those in group B received serial 35% Glycolic acid peels plus Modified Kligman's regimen over 3 months. Outcomes were measured at 4, 8, and 12-weeks post-treatment in terms of the MASI score. Results: Most of the patients i: e.75.5 % in group B showed moderate clinical improvement while most of the patients in group A i: e. 53.3% observed only mild improvement. In terms of the mean MASI score improvement, the Group B patients exhibited a significantly greater reduction from baseline compared to the Group A (8.91±2.42 vs. 7.05±4.05, p=0.010). Conclusions: The combination of Glycolic acid peels plus Modified Kligman's regimen is relatively more efficacious as compared to Modified Kligman's regimen alone.
Overweight and its Associated Risk Factors among Students in Tertiary Institutions of Learning in Mongu District of Western Province, Zambia; A cross-sectional Survey.
Authors: Mooka Larry , Mukumbuta Nawa , Funduluka Priscilla 
Published: April 2024

Introduction: Overweight and obesity are key public health issues in many high-income countries and have become a major public health concern affecting all ages, including adolescents in low-income and middle-income countries. This study determined the prevalence of overweight and obesity and their associated factors among undergraduate students at colleges and universities in the Mongu district of the Western Province of Zambia.
Methods: This was a cross-sectional study. Undergraduate students aged 18 to 26 years were sampled from two colleges and one university in Mongu. Data was collected electronically by trained research assistants using a structured questionnaire using Kobo Collect software. Data was analysed using Stata version 14 software. The analysis included descriptive statistics, using counts, frequencies, percentages, means and medians depending on the distribution of the data. Chi-squared tests of association, bivariate, and multivariate logistic regression were done to test for association between overweight and independent variables. A p-value less than 0.05 was considered significant.
Results: A total of 330 students were captured in the survey; over half of the respondents were female students 214 (64.85%), while 116 (35.15%) were male respondents. Body Mass Index (BMI) showed that 21 (6.8%) were underweight, 208 (63.0%) had normal weight, 76 (23.0%) were overweight, and 25 (7.6%) were obese. Factors associated with overweight and obesity included female sex aOR 1.68 (95%CI 1.02 – 2.76), age and alcohol intake.
Conclusions: A third of the students were either overweight or obese. Sex, age and alcohol intake were significantly associated with overweight and obesity among students. The prevalence of overweight and obesity is high among young adults, and this calls for early interventions in learning institutions to combat obesity.
Keywords: Overweight, obesity, body mass index, prevalence, diet, sex.
Adult Learners' Community Cultural Wealth: Seeing ABE Learners through a CRT Lens
Authors: Pickard Amy 
Published: April 2024

As a field, adult basic education (ABE) has been slow to address racial injustice or to consider how racism informs commonly-held, deficit-based beliefs about adult literacy students. This ethnographically-grounded research article utilizes Critical Race Theory (CRT) and Yosso's (2005) framework of community cultural wealth to highlight the culturally-grounded assets two ABE learners brought to their reading class. I argue that increased acknowledgement of community cultural wealth could improve services to the many racially marginalized adults who participate in publicly-funded ABE programs.
Digital Innovations in Pneumonia Care: A Mini Review
Authors: Tripathy Snehasish , Negi Sapna , Mathur Ankita , Mehta Vini 
Published: April 2024

Introduction: Pneumonia is a severe respiratory disease threatening public health and requires timely and accurate diagnosis and early intervention for effective treatment. The emergence of telemedicine during COVID-19 has offered new solutions to solve health problem. This review examines recent studies focusing on effectiveness of telemedicine intervention in pneumonia care.
Methods: We systematically searched five databases to retrieve original research that addressed telemedicine's use in pneumonia diagnosis, treatment, monitoring, or patient assistance. Two independent reviewers performed screening to confirm alignment with inclusion criteria. The findings were synthesised narratively.
Results: A total of five studies were included in the review. The interventions across studies were telephonic follow-ups, Smartphone-based algorithm for diagnosing pneumonia, telemedicine set-up at patients' homes and Interactive videoconferencing. The findings suggest that telephone consultation is effective for patients with low-risk respiratory infections and may be more effective in early diagnosis of pneumonia patients.
Conclusion: The planning for work in telemedicine, whether in regulations or private practice, is necessary to ensure the quality, safety, and consistency of telemedicine practices. The use and availability of telemedicine services, especially in rural areas and on mobile phones, must be expanded to reduce problems in the region.
Penambahan Kalsium Terhadap Pertumbuhan Ayam Broiler 1-45 Hari
Authors: Noviandi Idham , Sastrawan Sandri , Erita Erita 
Published: March 2024

Penelitian ini bertujuan untuk mengetahui pemberian tepung tulang dapat meningkatkan pertambahan berat bobot Ayam Broiler. Penelitian ini dilaksanakan di Lab Kandang Peternakan Fakultas Pertanian Universitas Gajah Putih Takengon. Penelitian ini berlangsung mulai tanggal 5 Juli – 20 Agustus 2020. Dengan Mengunakan Rancangan Acak Lengkap (RAL)dengan 4 perlakuan dan diulang 3 kali. Hasil penelitian ini menunjukkan bahwa Penggunaan Kalsium berpengaruh nyata terhadap pertambahan berat bobot Ayam Broiler, hasil yang tertinggi dijumpai pada perlakuan P3 sebesar 1,16 Gram/ekor/hari, kesimpulan menunjukkan bahwa berat bobot Ayam Broiler berpengaruh nyata diantara perlakuan penggunaan pemberian Kalsium dari total pertambahan berat bobot Ayam Broiler
Pseudomonas siderophores: production, spectrophotometry detection and Botrytis suppression
Authors: QESSAOUI Redouan , ELAAlAOUI Mohamed , CHAFIKI Salahddine , ALOUANI Mohamed , CHABBI Naima , AIT ABD Naima , TAHIRI Abdelghani , BOUHARROUD Rachid 
Published: April 2024

Siderophores are iron-chelating agents produced by almost all microorganisms in response to iron deficiency. Due to the requirement of iron for cell growth and metabolism, siderophore-mediated acquisition of iron plays a central role in determining the ability of different microorganisms to colonize plant roots and contributes to microbial interactions in the plant rhizosphere. In this study, five new Pseudomonas (Q14B, Q13B, Q7B, Q6B, Q1B), isolated from the rhizosphere of tomato in Morocco, were examined for siderophores production capacity. The results show that all five isolates produced siderophores on both solid and liquid mediums. In liquid medium, the highest level of production is obtained by Q13B (53.8%). Concerning siderophores’ chemical types, the five strains of Pseudomonas produce two types of siderophores hydroxamate and catecholate. It was shown by the peaks of absorbance in the wavelength 495 and between 420-450 nm for catecholate and hydroxamate-type siderophores respectively. The results showed that the production of siderophores is progressively inhibited with increasing concentrations of iron in the medium. The maximum production was obtained with a concentration of 0.5 μM, while the lowest was recorded at 10.0 μM of iron. The results of this study showed that the five Pseudomonas isolates producing siderophores could be potential biological control agents.
Implementasi kebijakan vaksinasi covid -19 di Kota Medan menggunakan teori edward III
Authors: Dalimunthe Yowanda Pasyah , Susilawati Susilawati 
Published: April 2024

Peraturan Presiden Nomor 99 Tahun 2020 Tentang Pengadaan Vaksin dan Pelaksanaan Vaksinasi dalam Rangka Penanggulangan Pandemi Corona Virus Disease 2019 (COVID- 19) Pasal 13A ayat (2) menyatakan bahwa setiap orang yang ditetapkan sebagai sasaran penerima vaksin COVID-19 wajib mengikuti Vaksinasi COVID-19. Vaksinasi adalah proses di dalam tubuh, dimana seseorang menjadi terlindungi dari suatu penyakit sehingga apabila terpapar dengan penyakit tersebut maka tidak akan sakit atau hanya mengalami sakit ringan. Vaksinasi tidak hanya bertujuan untuk memutus rantai penularan penyakit, tetapi juga dalam jangka panjang untuk mengeliminasi bahkan mengeradikasi penyakit itu sendiri. Metode penelitian ini menggunakan kualitatif untuk memperoleh data deskriptif dengan menganalisis teori implementasi kebijakan Edward III yang meliputi komunikasi, sumber daya, disposisi, dan struktur birokrasi dengan teknik pengumpulan data studi kepustakaan. Menurut wali kota Medan, vaksinasi sebagai upaya mempercepat terwujudnya kekebalan kelompok yang telah mencapai 78,55% di Kota Medan. Himbauan ini dilakukan agar kasus covid segera tiada. Lalu, ketersediaan tenaga dibidang kesehatan juga mendukung proses implementasi kebijakan. Pemerintah Kota Medan memberikan 20.000 vaksin COVID-19 tahap pertama yang diprioritaskan pada tenaga kesehatan. Selanjutnya, perilaku yang dipunyai implementator kebijakan juga bisa berpengaruh pada tingkat keberhasilan kinerja. Alhasil, vaksinasi COVID-19 melakukan pembagian tugas dari pemerintah pusat ke provinsi selanjutnya diserahkan ke pemerintah kota.