bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Corneal Indentation Device for Comparison of Corneal Tangent Modulus before and after FS-LASIK in vivo
Authors: Zhang Yan , Lin Junyu , Lu Shu-Hao , CHONG Jones Iok-Tong , Yang Cheng , Lan Jianqing , Xie Wenjuan , Li Juan , LAM David Chuen-Chun , Cao Dan , Zeng Jin 
Published: March 2024

Abstract
Background
Corneal refractive laser surgery is widely used to correct myopia and astigmatism due to its safety and effectiveness. However, postoperative changes in corneal biomechanics, such as corneal ectasia, can occur, necessitating a deeper understanding of these changes. Finite Element Analysis has shown promise in predicting surgical outcomes based on corneal biomechanics. Devices like the Ocular Response Analyser (ORA) and Corvis ST provide noninvasive ways to measure corneal biomechanics, aiding in the assessment of corneal behavior post-surgery. Young's modulus and tangent modulus are crucial parameters for describing corneal elasticity, but there is limited data on the changes in tangent modulus following Femtosecond Laser-Assisted LASIK (FS-LASIK) in humans. This study aimed to investigate the effect of FS-LASIK on the corneal tangent modulus using a novel corneal indentation device (CID). The study sought to explore changes in corneal tangent modulus after FS-LASIK, taking into account central corneal thickness (CCT) and corneal radius, to enhance our understanding of the biomechanical changes induced by this surgical procedure.
Results
Sixty-six patients (66 eyes) underwent FS-LASIK, resulting in significant changes in CCT, corneal radius, and Goldmann intraocular pressure (GAT IOP) six months post-surgery (△CCT=-88 ± 31 µm, △corneal radius = 0.81 ± 0.30 mm, △GAT IOP=-3.2 ± 2.4 mmHg, p < 0.001) 6 months after surgery. However, corneal stiffness did not significantly change (△=-0.002 ± 0.011, p < 0.2). The corneal tangent modulus showed a significant increase post-surgery (△=0.263 ± 0.146, p < 0.001), exhibiting a negative correlation with CCT (r = -0.68, P < 0.001) and a positive correlation with corneal radius (r = 0.71, P < 0.001). For each 1 mm increase in corneal radius, there was a 0.23 MPa increase in corneal modulus, and for every 100 µm reduction in corneal thickness, there was a 0.14 MPa increase in corneal modulus.
Conclusions
The corneal tangent modulus, influenced by corneal radius and CCT, increased significantly following FS-LASIK. This study highlights the biomechanical changes induced by FS-LASIK, with implications for understanding corneal behavior post-surgery and its potential impact on patient outcomes.
A Retrospective Analysis: A Predictive Model Using Platelets and Neutrophil-to- Lymphocyte Ratio for the Number of Lymph Node Metastasis in Papillary Thyroid Carcinoma
Authors: Chen YuYing , Wu Fan , Ge Mengqian , Hu Tao , Qian Shuoying , Cai Yuan , Huang Xuanwei , Huang Kaiyuan , Pan Gang , Luo Dingcun 
Published: March 2024

Abstract
Objective The aim of this study was to investigate the high-risk clinical factors for large-number lymph node metastases (LNLNM) inthyroid papillary carcinoma (PTC).
Methods The clinicopathological data from the 731 PTC patients who underwent thyroid operation between September 2021to October 2022 in the surgical oncology of Affiliated Hangzhou First People’s Hospital, Westlake University School of Medicine were collected. Univariate and multivariate logistic analyses were conducted to identify risk factors for LNLNM in PTC. A predictive model for assessing LNLNM in PTC was established and validated by using receiver operating characteristic curves (ROC), the Hosmer-Lemeshow (HL)test, calibration curves, and decision curve analysis (DCA).
Results Age, tumor diameter, platelets and neutrophil-to-lymphocyte ratio (NLR) were identified as independent risk factors for LNLNM in PTC patients. A predictive model was developed to evaluate the risk of LNLNMwith an area under the curve (AUC) of 0.827 (P<0.001, 95%CI: 0.784-0.870) and the specificity and sensitivity were both 75.8%. The AUC of the validation group was 0.824(P<0.001, 95%CI: 0.757-0.890) with a specificity of 79.5% and a sensitivity of 76.0%. Furthermore, themodel demonstrated good calibration through the HL test and favorable diagnostic value by calibration curve and DCA.
Conclusion Age, tumor diameter, platelets and NLRare high-risk factors for LNLNM in PTC, and the predictive model established in combination with the above factors couldeffectively predict the occurrence of LNLNM in PTC. This study provides support for surgeons to accurately predict the possibility of LNLNM and develop personalized treatment plans before surgery.
Seismic stability chart for 3D Hoek-Brown rock slope: A novel approach integrated tension cutoff and dynamic seismic effect
Authors: Sun Zhibin , Lou Chenglong , Jin Can , Xu Jingshu , Dias Daniel 
Published: March 2024

Abstract

Stability charts are a robust tool for rapidly assessing the stability of slopes in Hoek-Brown (HB) rocks. A notable shortcoming of previous charts has been their limited focus on slip-shear failure induced by equivalent static seismic forces, largely neglecting the potential for tensile failure due to rupture of material, and the dynamic aspects of seismic motion. To enhance the precision of existing chart methodologies, this paper introduces an innovative stability chart for width-restricted HB rock slopes. Seismic safety factors (\({F_s}\)) for constructing the chart are derived through upper bound limit analysis (UBLA). To incorporate the rock's tensile strength, an equivalent linearization of the HB criterion with a tension cutoff is proposed and utilized within an advanced horn-like mechanism. This mechanism features segments that account for tensile and shear forces to facilitate the integration of slope tensile failure. The dynamic seismic influences are captured using a pseudo-dynamic approach, which assumes sinusoidal seismic wave propagation and aids in the incorporation of dynamic seismic parameters such as wave velocity, period, and amplification factor. Utilizing the UBLA-based \({F_s}\), novel charts are developed. Charts incorporating a tension cutoff are enhanced for both intact and jointed rock masses. Two correction factors are introduced to account for the impacts of phase changes and acceleration amplification. Derived from the analysis of extensive datasets, these factors enable the conversion of published chart solutions into more accurate pseudo-dynamic outcomes.
Racial/Ethnic Differences in Long-COVID-Associated Symptoms among Pediatrics Population: Findings from Difference-in-differences Analyses in RECOVER Program
Authors: Chen Yong , Zhang Dazheng , Zhang Bingyu , Wu Qiong , Zhou Ting , Tong Jiayi , Lu Yiwen , Chen Jiajie , Wang Huiyuan , Chisolm Deena , Jhaveri Ravi , Kenney Rachel , Rothman Russel , Rao Suchitra , Williams David , Hornig Mady , Morris Jeffrey , Forrest Christopher 
Published: March 2024

Abstract

Racial/ethnic differences are associated with the potential symptoms and conditions of post-acute sequelae SARS-CoV-2 infection (PASC) in adults. These differences may exist among children and warrant further exploration. We conducted a retrospective cohort study for children and adolescents under the age of 21 from the thirteen institutions in the RECOVER Initiative. The cohort is 225,723 patients with SARS-CoV-2 infection or COVID-19 diagnosis and 677,448 patients without SARS-CoV-2 infection or COVID-19 diagnosis between March 2020 and October 2022. The study compared minor racial/ethnic groups to Non-Hispanic White (NHW) individuals, stratified by severity during the acute phase of COVID-19. Within the severe group, Asian American/Pacific Islanders (AAPI) had a higher prevalence of fever/chills and respiratory symptoms, Hispanic patients showed greater hair loss prevalence in severe COVID-19 cases, while Non-Hispanic Black (NHB) patients had fewer skin symptoms in comparison to NHW patients. Within the non-severe group, AAPI patients had increased POTS/dysautonomia and respiratory symptoms, and NHB patients showed more cognitive symptoms than NHW patients. In conclusion, racial/ethnic differences related to COVID-19 exist among specific PASC symptoms and conditions in pediatrics, and these differences are associated with the severity of illness during acute COVID-19.
Learning Curve Analysis of Transvaginal Natural Orifice Transluminal Endoscopic Surgery in Treating Ovarian Cysts: A Retrospective Cohort Study
Authors: Feng Dan , Liu Tianjiao , Xiao Li , Li Xin , Huang Lu , He Li , Lin Yonghong 
Published: March 2024

Abstract

Background：Transvaginal Natural Orifice Transluminal Endoscopy (vNOTES) is regarded as a challenging surgical technique to learn but is promising in reducing perioperative pain and significantly improves the cosmetic outcomes. Previous studies on the learning curve analysis of vNOTES mainly focuses on the hysterectomy approach, while the vNOTES ovarian cystectomy’s learning curve was merely reported thought more frequently performed than vNOTES hysterectomy. Therefore, this study seeks to analyze the learning curve of three surgeons with varying levels of experience in performing endoscopic surgery for the treatment of ovarian cysts using vNOTES.
Methods: A total of 127 patients with ovarian cysts of a variety of pathological types were treated by vNOTES ovarian cystectomy performed by three surgeons of different levels of endoscopic surgical experience. Each surgeon’s learning curve was plotted using the Cumulative Sum method and divided into three or four phases of technique learning at the turning point of the learning curve. The sociodemographic and clinical features of patients in each phase were then compared and factors potentially associated with operation time were also screened.
Results: The learning curve was presented in four phases. The operation time (OT) was significantly shorter in phases II (53.66 ± 16.55 min) and IV (54.39 ± 23.45 min) as compared with phases I (68.74 ± 15.85) and III (75.93 ± 30.55) (p <0.001). More cases of serve pelvic adhesion and chocolate cyst were assigned in the later phases. The presence of pelvic adhesion [adjusted odds ratio (OR) 7.149 (0.506, 13.792), p = 0.035] and bilateral cyst [adjusted OR 16.996 (2.155, 31.837), p = 0.025], max diameter of cyst[adjusted OR 2.799 (0.174, 5.425), p = 0.037], and surgeon’s experience [adjusted OR -6.118 (-11.814, -0.423), p =0.035] were significantly associated with OT.
Conclusion: There learning curve of ovarian vNOTES has four phases. vNOTES ovarian cystectomy could be mastered after performing seven, nine, and 16 cases by surgeons with the most, average, and least experience in gynecologic endoscopic surgeries.
Trial registration: ChiCTR2200059282 (Registered on April 28th, 2022)
Research on Robotic Polishing Process of Marble with Complex Curved Surface based on Sol-Gel Flexible Tools
Authors: Guo Yaobin , Huang Shengui , Huang Jixiang , Lu Jing 
Published: March 2024

Abstract

The newly developed Sol-Gel (SG) flexible tools are used to polish complex marble surfaces with a robot to achieve a high gloss, low roughness, and scratch-free surface. The SG tool is composed of semi-solid abrasive and flexible fiber pads, which can realize a dual yielding effect at both the micro and macro levels, so that the SG flexible tool can better fit to the complex curved surface. Through the simulation analysis of the contact of SG flexible tools, the relationship between different curvature surfaces and polishing force was obtained. Based on the Preston material removal theory, constant pressure polishing of surfaces of different curvature was achieved by simulating the contact force distribution between the SG flexible tool and the marble surface, as well as the constant pressure material removal profile. By optimizing the space of the polishing trajectory, the uniformity of the material removal depth was improved, and the consistency of surface quality after polishing was enhanced. By establishing a model that correlates the optimum polishing trajectory space with curvature for surfaces of different curvature, the effective prediction of material removal profiles for robotic polishing of surfaces of different curvature was achieved. These strategies aim to ensure surface consistency after polishing complex curved surface under different conditions, thereby increasing product added value. This research provides initial theoretical guidance for the application of SG flexible tools in robotic polishing of marble with complex curved surface.
The Effect of Electronic Cigarette Use on Female Sexual Functions
Authors: Culha Mehmet , Kara Tugba 
Published: March 2024

Abstract
Aim While the effect of tobacco use on female sexual functions is known, the effect of electronic cigarettes on female sexual functions is unknown. The aim of this study is to investigate whether electronic cigarette use influences female sexual functions.Method Female patients over the age of 18 who applied to the Chest Diseases Polyclinic between July and August 2023 were included in the study. Patients were divided into 3 groups according to smoking status. Patients who consume tobacco products, patients who consume electronic cigarettes, and patients who do not smoke. Participants filled out the Female Sexual Function Scale (FSFI), which consists of 19 questions. Participants' sexual function scores were compared between groups. Female Sexual Dysfunction (FSD) rates were evaluated between groups.Results A total of 171 women participated in the study. The mean age of the participants was 34.25 ± 7.51 (19–58). Participants who smoked were divided into two groups: tobacco smokers (n = 56) and electronic cigarette users (n = 44). 71 participants who did not smoke constituted the control group. A total of 72 patients (42.1%) were found to have FSD. When the electronic cigarette group and the control group were compared, the FSFI-orgasm, satisfaction, pain and total FSFI scores of the participants in the e-cigarette group were found to be lower than the control group (p = 0.005 for orgasm, p = 0.029 for satisfaction, p = 0.046 for pain and Total p = 0.040 for FSFI). More FSD was observed in the cigarette group and e-cigarette group than in the control group (26.8% for the control group, 48.2% for the cigarette group, 47.7% for the e-cigarette; p < 0.001).Conclusion FSD can be seen in women who use e-cigarettes as frequently as in women who smoke regular cigarettes, and FSD is seen at a higher rate than in women who do not smoke.
Nucleolar protein interacting with the FHA domain of MKI67 may be an important factor in promoting the development of colorectal cancer: a comprehensive study integrating bulk RNA-seq, scRNA-seq, protein immunohistochemistry and CRISPR
Authors: Li Hui , Tang Yu-Xing , Chen Yi , Huang Wan-Ying , He Rong-Quan , Huang Zhi-Guang , Zeng Da-Tong , Xia Zhi-Yuan , Song Rui , Zhang Han Jie , Chen Yu-Zhen , Zhao Bin-Hui , Qin Si-Ru , Luo Jia-Yuan , Chen Gang 
Published: March 2024

Abstract

Background
Limited evidence suggests that nucleolar protein interacting with the FHA domain of MKI67 (NIFK) plays a significant role in tumour occurrence and development. The mechanism and clinical value of NIFK in colorectal cancer (CRC) still lack a comprehensive evaluation.
Materials and Methods
Cancerous tissue and paracancerous tissue of 266 CRC patients were collected for immunohistochemistry, and the mRNA expression profiles of 2262 CRC tissue and 1297 non-CRC tissue worldwide were collected and analysed at the NIFK protein and mRNA levels. Analyse the effect of knocking out NIFK by CRISPR on the growth status of CRC cells in 43 CRC cell lines. Enrichment analysis was used to explore the potential biological behaviour of NIFK in the CRC. The impact of NIFK on the immune microenvironment and single-cell landscape of CRC tissue was also analysed. In addition, the clinical value of NIFK in CRC was also evaluated in terms of clinical pathology, targeted therapy, and immunotherapy.
Results
The expression levels of NIFK protein (p < 0.05) and mRNA (SMD = 2.13, p < 0.05) in CRC were significantly higher than those in non-CRC. CRC cells exhibit a strong requirement for NIFK for growth. Abnormal expression of NIFK may affect the progression of CRC by affecting the GALECTIN, ANGPTL, and GDF signalling pathways of malignant epithelial cells, the MIF signalling pathway of T cells, and the TGFb signalling pathway of NK cells. The high expression of NIFK protein and mRNA has a strong ability to identify CRC.
Conclusion
NIFK plays an important role in the occurrence and development of CRC. NIFK may promote the occurrence and development of CRC through the cell cycle, ribosome, and mitochondrial pathways. The T-cell MIF pathway may have certain clinical value in anti-tumour therapy.
Awareness, Knowledge, and Practice towards Medication Overuse Headache in Thailand: A University Hospital-Based Survey in a Residency Training Program
Authors: Anukoolwittaya Prakit , Pongpitakmetha Thanakit , Hiransuthikul Akarin , Thanprasertsuk Sekh , Rattanawong Wanakorn 
Published: March 2024

Abstract
Background:Medication Overuse Headache (MOH) represents a significant challenge in patient care, with physicians playing a vital role in its prevention and management. Nonetheless, awareness, knowledge, and practices concerning MOH among physicians are often found to be inadequate.
Methods:A cross-sectional university-based hospital study was conducted to investigate awareness, knowledge, and practices related to MOH among resident doctors from family medicine, internal medicine, and neurology specialties. Participants were surveyed using an internet-based questionnaire.
Results:70 out of 130 residents participated in this study. 10% of participants were unaware that analgesia could exacerbate headaches. 11.4% of participants were uncertain about the classification of MOH. 31.4% and 44.3% of participants were unsure about the frequency of simple analgesia and migraine-specific drug use leading to MOH, respectively. 22.9% of participants prescribed opioids for abortive treatment in migraine patients. Neurology residents performed better in many aspects compared with others.
Conclusion:The findings highlight the need for improved MOH education across medical specialties to enhance patient care and reduce the healthcare burden of MOH.
Blood metabolome profiling for patient stratification and assessment of disease severity among Asian Indian patients with Type 2 diabetes mellitus
Authors: Rana Sneha , Mishra Vivek , Nakrani Prajval , Kumar Ega Lakshman , Sahay Manisha , Sahay Rakesh Kumar , Wangikar Pramod P. 
Published: March 2024

Abstract

Introduction: Type 2 diabetes mellitus is a heterogeneous disease with broader metabolic perturbation beyond hyperglycemia, resulting in varied prognoses. Clustering analyses using clinical features have identified at least four sub-types with differing disease progression among patients with type 2 diabetes. Additionally, patients are at risk of developing complications such as diabetic kidney disease (DKD), the early stages of which are clinically silent. Metabolomics offers a comprehensive understanding of the underlying metabolic intricacies, beyond conventional clinical markers such as glucose and creatinine.
Objective: We aimed to identify significant metabolites that can help in patient stratification and early assessment of DKD in Indian patients with type 2 diabetes.
Methods: In this case-control study, we used mass spectrometry coupled to liquid (LCMS) and gas chromatography (GCMS) to profile metabolites from the whole blood samples from a cohort of Asian Indians belonging to three groups: non-diabetic, Type 2 diabetes, and DKD.
Results: We identified 290 unique metabolites using both LCMS and GCMS, of which 26 and 20 metabolites were significantly associated with Type 2 diabetes and DKD, respectively, after p-value correction for false discovery rate. K-means and hierarchical clustering revealed two distinct sub-groups within the type 2 diabetes group with nine significant metabolites indicating differences in disease severity. Furthermore, seven metabolites showed progressive changes from non-diabetic to type 2 diabetes to DKD.
Conclusion: Metabolome profiling has the potential to be used for patient stratification and early diagnosis of DKD in Indian patients with type 2 diabetes in Asian Indians, towards facilitating personalized treatment with timely intervention.
A real-world pharmacovigilance analysis of FDA adverse event reporting system database for baloxavir marboxil
Authors: Hai Le , Wu Jiaojiao , Pan Xiaohong , Tu Xiaoqin , Xie Yingying , Su Gui 
Published: March 2024

Abstract

Baloxavir marboxil represents a groundbreak drug as the premiere agent targeting influenza with an innovative mechanism of action. The study was to investigate the adverse events and provide reference for clinical safety. The adverse events data were collected from the U.S. FDA Adverse Event Reporting System (FAERS) database covering the first quarter of 2018 to the third quarter of 2023. Two methods, reporting odd ration (ROR) and bayesian confidence propagation neural network (BCPNN) were used to detect the adverse events risk signal. A total of 1671 adverse events reports with baloxavir marboxil as the main suspected drug were collected. More women and patients under 18 years of age were reported. It was found that the adverse events signals involved multiple systems, among which the high-risk signals included melena, altered state of consciousness, delirium, abnormal behavior, rapid severe anaphylaxis, anaphylactic shock and erythema multiforme. Safety warning signs of ischemic colitis and rhabdomyolysis, which were high risk and not mentioned in the instructions, were also detected. In addition to the adverse events recorded in the manual, ischemic colitis, neuropsychiatric symptoms, allergic reactions, severe skin adverse reactions and rhabdomyolysis in the clinical application of baloxavir marboxil also should be paid attention to ensure the safety of patients.
Headaches in SLE Patients: A Cross-Sectional Analysis of Clinical, Immunological, and Radiological Correlations
Authors: Samy Eman , Zahran Enas S. , Sabry Mona , Elshony Hosna Saad 
Published: March 2024

Abstract
Background
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disorder presenting with diverse clinical manifestations, among which headaches are prominent. This cross-sectional study aimed to comprehensively investigate the relationship between SLE and headaches, analyzing prevalence, types, and their clinical, immunological, and radiological implications.
Method
A comparative study included 179 SLE patients categorized into Headache and Non-Headache groups. Demographics, disease activity, neurological information, immunological investigations, and brain imaging were collected. Headaches were diagnosed and classified using the International Classification System, Activity index was done using SLE disease activity index (SLEDAI).
Results
Headaches affected 55% of SLE patients, mostly as tension-type (65%) and migraine (27%) headaches. None met the lupus headache criteria. Disease activity (SLEDAI) was significantly higher in the Headache Group. Muco-cutaneous manifestations were associated with tension-type and migraine headaches. Anti-phospholipid (APL) antibody positivity showed a significant association with migraine and cluster headache. Neuropsychiatric manifestations, including ischemic stroke and venous sinus thrombosis, were more prevalent in Headache Group, although not clinically significant. Brain MRI abnormalities were observed in 8% of headache sufferers, including venous sinus thrombosis (2%), ischemic stroke (5%) and white matter hyperintensities (1%).
Conclusion
Our study reveals complex relationship between SLE and headaches, emphasizing the potential clinical relevance of headaches as markers for increased SLE disease activity. Immunological factors, particularly APL antibodies, show associations with specific headache types. Brain imaging abnormalities underscore the intricate neurobiological landscape in SLE patients with headaches. Further research is warranted to explore biomarkers, treatment impacts, and intervention strategies for managing headaches in SLE patients.