bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute coronary artery closure following intracoronary ultrasound examination
Authors: Ge Junbo , Liu Fengqi , Kearney Peter , Görge Günter , Haude Michael , Erbel Raimund 
Published: March 2007

AbstractTwo patients undergoing intracoronary ultrasound examination were complicated by acute coronary artery closure. One of the complications was thought to be caused by intimal dissection and thrombus formation and the other was thought to be caused by intimal dissection and subsequent embolization. The complications were successfully managed conservatively in both cases. © 1995 Wiley‐Liss, Inc.
Retrieval of directional coronary atherectomy guiding catheter with angioplasty balloon catheter
Authors: El Ghamry Sabe Ahmed A. , Ettinger Steven M. 
Published: March 2007

AbstractDirectional coronary atherectomy (DCA) has been shown to be a safe and effective treatment for occlusive coronary artery disease. We report a case of an atherectomy guiding catheter severing in two with successful retrieval of the dislodged segment by an integrated angioplasty balloon catheter system. © 1995 Wiley‐Liss, Inc.
Separation of a flexible nose cone tip during directional atherectomy
Authors: Rashkow Andrew M. 
Published: March 2007

AbstractAn 82‐yr‐old white female underwent directional coronary atherectomy of a high‐grade proximal left anterior artery stenosis. The nose cone tip of a Simpson Atherocath SCAEX™ separated during loading of the device onto a 360‐cm exchange wire. This was recognized prior to insertion through a rotating hemostatic valve and exchanged for another device. Catheterization laboratory policy regarding defective devices is briefly discussed. © 1995 Wiley‐Liss, Inc.
Clinical effects and utility of intracoronary diltiazem
Authors: McLvor Michael E. , Undemir Cenap , Lawson Janet , Reddinger Judith 
Published: March 2007

AbstractCoronary artery spasm is a known complication of coronary interventions, for which intracoronary nitroglycerin (ICN) is the treatment of choice. Some forms of intense spasm are resistant to ICN. Calcium channel antagonists are also known to be effective for coronary artery spasm, including nitroglycerin‐resistant spasm. Here we describe a protocol for the clinical use of intracoronary diltiazem (ICD). By this protocol, ICD can be safely given without disturbing the clinical status of patients. ICD (2.5 mg) given slowly over 1 minute produced no vasodilitation of normal vessel segments but did produce significant dilatation of stenotic segments above and beyond the effects of nitrates. Mean minimum lumen diameter increased 18%, from 0.89 ± 0.06 mm to 1.06 ± 0.07 mm (mean ± SEM, P < 0.001). ICD produced clinically Insignificant changes in systolic blood pressure, diastolic blood pressure, heart rate, and PR, QRS, and QT intervals. This protocol has been employed to safely use ICD to relieve both nitroglycerin‐resistant epicardial artery spasm and nitroglycerin‐resistant distal microvascular spasm (the no‐reflow phenomenon). © 1995 Wiley‐Liss, Inc.
Congenital clavicular pseudoarthrosis associated with vascular thoracic outlet syndrome: Case presentation and review of the literature
Authors: Hahn Kenneth , Shah Rita , Shalev Yoseph , Schmidt Donald H. , Bajwa Tanvir 
Published: March 2007

AbstractThoracic outlet syndrome (TOS) associated with congenital clavicular pseudoarthrosis is rare in adults and often misdiagnosed. In this case report, we describe an adult female who was found to have thromoosis of the subclavian and axillary arteries with embolization documented by invasive angiography. This unusual vascular manifestation of TOS should remind physicians that anatomic derangements may predispose to upper extremity ischemia. © 1995 Wiley‐Liss, Inc.
Right coronary artery pseudo‐transection due to mechanical straightening during coronary angioplasty
Authors: Blankenship James C. 
Published: March 2007

AbstractStraightening of tortuous coronary arteries during coronary angioplasty may produce transient angiographic defects that have a typical invaginated appearance. We report a case in which coronary straightening produced an unusual defect mimicking severe damage to the artery. Recognition and conservative management were essential to avoid complications. © 1995 Wiley‐Liss, Inc.
Rotational atherectomy in restenotic lesions at the distal saphenous vein graft anastomosis
Authors: Cardenas Joseph R. , Strumpf Robert K. , Heuser Richard R. 
Published: March 2007

AbstractRestenotic lesions at distal saphenous vein graft (SVG) anastomoses have been notoriously difficult to treat with standard angioplasty techniques. We explored the potential of rotational atherectomy in three patients with nonthrombotic, focal restenoses at the SVG touchdown. The Rotablator safely and successfully recanalized the lesions, allowing further treatment with dilation or stenting or both. Rotational atherectomy may warrant investigation as a treatment for nonthrombotic restenotic SVG lesions. © 1995 Wiley‐Liss, Inc.
Initial experience with an intracoronary flow support device providing localized drug infusion: The scimed dispatch catheter
Authors: Groh William C. , Kurnik Peter B. , Matthai William H. , Untereker William J. 
Published: March 2007

AbstractTwo cases are presented illustrating the use of a new intracoronary infusion catheter providing flow support using a unique spiral coil design. Good clinical outcomes were obtained employing 4‐hr inflations with localized infusion of urokinase at the site of dissection and extensive clot formation, respectively. This low‐profile catheter‐mounted device may provide an alternative to stent placement in cases of acute dissection complicated by thrombus formation. © 1995 Wiley‐Liss, Inc.
Pilot prospective evaluation of counterpulsation with different intra‐aortic balloon volumes on cardiac performance in humans
Authors: Cohen Marc , Patel Janmejay J. , Dohad Suhail , McBride Ruth , Venkatesulu Sunder , Boston Barbara A. , Chandrasekaran Krishnaswamy 
Published: March 2007

AbstractSmaller intra‐aortic balloons (IAB) may minimise Peripheral vascular complications. To determine the influence of different IAB valumes on cardiac performance, we studied 20 hemodynamically stable patients on IAB counterpulsation. Variables were measured with either a 40cc or 32cc IAB displacement, at an assist ratio of 1:1 or 1:8 Heart rate, Ao and PA pressures, and Fick cardiac output. By echo‐Doppler, the velocity time integral (VTI) across the LV outflow track, a measure of stroke volume was also calculated. The mean age was 60 yr (range 18–77), height (5′2″–5′11″), and body surface area 1.9M2 (1.5‐2.3). Results presented as mean values were:

IAB/Vol
AR
VTI*
Ao (sys)
PA (mean)
HR (bpm)
CO

40cc
1:1
17.4
111
26
93
5.7

32cc
1:1
17.4
109
26
93
5.9

40cc
1:8
13.7
118
29
98
5.2

32cc
1:8
14.1
118
29
97
5.4

* p < 0.005 1:1 vs. 1:8 for both 40 and 32cc IAB.

Conclusion: IAB pumping at 1:1 with either 40cc or 32cc volumedisplacement yields similar degrees of improvement in cardiac performance. A larger cohort is required to determine if smaller balloons may decrease complications without compromising efficacy. © 1995 Wiley‐Liss, Inc.
Extensive intramural hematoma as the cause of failed coronary angioplasty: Diagnosis by intravascular ultrasound and treatment by stent implantation
Authors: Werner Gerald S. , Figulla Hans R. , Grosse Walter , Kreuzer Heinrich 
Published: March 2007

AbstractDissections after coronary angioplasty are the major cause of ischemic events following percutaneous transluminal coronary angioplasty (PTCA) and may require additional measures such as intravascular stent deployment to relieve or prevent acute vessel closure. We describe a rare type of dissection after PTCA which caused a severe obstruction of the vessel segment proximal to the dilatation site without a visible dissection flap. Intravascular ultrasound was used to elucidate the morphology of the proximal vessel obstruction, which revealed an intramural hematoma extending into the proximal vessel segment as underlying mechanism. A Palmaz‐Schatz stent was placed at the entry site of this hematoma, which led to the relief of the proximal vessel obstruction. After 3 months of anticoagulation therapy the repeat coronary angiography showed no significant restenosis. This demonstrates the unique insight into the underlying morphology of failed PTCA by intravascular ultrasound, which can help to manage even rare and unusual complications. © 1995 Wiley‐Liss, Inc.
Percutaneous retrieval of a broken umbilical catheter from left atrium in a premature newborn
Authors: Ruiz Carlos E. , Nystrom Gerald A. , Butt Amjad I. , Zhang He Ping 
Published: March 2007

AbstractA 30‐week gestational age baby boy weighing 1,117 g born with cesarian section had a broken umbilical vein catheter lodged in the left superior pulmonary vein. We successfully retrieved the foreign body by percutaneous approach using a pigtail catheter and a snare wire under portable fluoroscopy. © 1995 Wiley‐Liss, Inc.
Extraction atherectomy for the recanalization of totally occluded aortocoronary saphenous vein grafts
Authors: Sullebarger J. Thompson , Puleo John 
Published: March 2007

AbstractThis report describes the successful treatment of totally occluded aortocoronary saphenous vein grafts with percutaneous transluminal extraction atherectomy (TEC) in three patients with severe angina and high reoperative surgical risk. The method presented here may provide an alternative to overnight urokinase infusion or repeat surgery in high risk patients. © 1995 Wiley‐Liss, Inc.
Strategies for the palliation of severe unprotected left main coronary artery disease: Use of newer technologies
Authors: Foster‐Smith Karl , Garratt Kirk N. , Núñez Boris D. , Hibbard Michael D. , Holmes David R. 
Published: March 2007

AbstractAngioplasty of unprotected left main coronary artery lesions is associated with high procedural and late mortalities. We describe the successful use of rotational coronary atherectomy with prophylactic supportive measures in the management of a heavily calcified unprotected left main lesion. This report demonstrates that high‐risk lesions, previously regarded as unapproachable, may be safely treated with newer technologies. © 1995 Wiley‐Liss, Inc.
Biokraftstoffe in Deutschland – Produktionskosten und Marktchancen
Authors: Festel G. 
Published: March 2007

AbstractDurch die steigende Nachfrage nach Erdöl und dessen Verknappung muss intensiv nach Alternativen gesucht werden. Die Entwicklung alternativer Kraftstoffe hat deshalb eine große Bedeutung erlangt. Aufgrund der Vielzahl an unterschiedlichen Biokraftstoffen und Einflussfaktoren bei der Bewertung der Kraftstoffe besteht im Moment kein klares Meinungsbild bezüglich der Möglichkeiten von Biokraftstoffen. Vorgestellt werden eigene Untersuchungen, die durchgeführt wurden, um geeignete Bewertungskriterien für Kraftstoffalternativen zu finden und die Realisierungschancen abzuschätzen.
On a class of pseudo‐logarithmic amplifiers suitable for use with digitally switched resistors
Authors: Maundy Brent , Westwick David , Gift Stephan 
Published: March 2007

AbstractThis paper describes three circuits that implement pseudo‐logarithmic functions, which are simple and easy to implement. The circuits can be realized using operational amplifiers or current feedback amplifiers. Tuning can be achieved using switched resistors, or active resistors, or tunable transconductors, but are best suited for use with digitally switched resistors. Frequency response and stability considerations for two of the circuits are thoroughly discussed and PSPICE results confirming the theoretical results are presented alongside measured results. Copyright © 2007 John Wiley & Sons, Ltd.
Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression
Authors: Bazzi Hisham , Fantauzzo Katherine A. , Richardson Gavin D. , Jahoda Colin A.B. , Christiano Angela M. 
Published: March 2007

AbstractThe mammalian epidermis is the first line of defense against external environmental challenges including dehydration. The epidermis undergoes a highly intricate developmental program in utero, transforming from a simple to a complex stratified epithelium. During this process of stratification and differentiation, epidermal keratinocytes express a defined set of structural proteins, mainly keratins, whose expression is controlled by largely unknown mechanisms. In order to identify novel factors contributing to epidermal morphogenesis, we performed a global transcriptional analysis of the developing mouse epidermis after separating it from the underlying dermis (E12.5–E15.5). Unexpectedly, the recently identified genes encoding secreted peptides dermokine (Dmkn), keratinocyte differentiation‐associated protein (krtdap), and suprabasin (Sbsn) as well as a largely uncharacterized embryonic keratin (Krt77), were among the most highly differentially expressed genes. The three genes encoding the secreted proteins form a cluster in an ∼40‐Kb locus on human chromosome 19 and the syntenic region on mouse chromosome 7 known as the stratified epithelium secreted peptides complex (SSC). Using whole mount in situ hybridization, we show that these genes show a coordinated spatio‐temporal expression pattern during epidermal morphogenesis. The expression of these genes initiates in the nasal epithelium and correlates with the initiation of other epidermal differentiation markers such as K1 and loricrin (Byrne et al. [1994]Development120:2369–2383), as well as the initiation of barrier formation. Our observations reveal a coordinated mode of expression of the SSC genes as well as the correlation of their initiation in the nasal epithelium with the initiation of barrier formation at this site. Developmental Dynamics 236:913–921, 2007. © 2007 Wiley‐Liss, Inc.
Differences in the antigens recognized by cytolytic T cells on two successive metastases of a melanoma patient are consistent with immune selection
Authors: Lehmann Frédéric , Marchand Marie , Hainaut Philippe , Pouillart Pierre , Sastre Xavier , Ikeda Hideyuki , Boon Thierry , Coulie Pierre G. 
Published: March 2007

AbstractWe have studied the patterns of antigens recognized by autologous cytolytic T lymphocytes (CTL) on two melanoma cell lines derived from metastases that were removed from patient LB33 at several years distance. Cell line LB33‐MEL. A was obtained after surgery in 1988. A large number of CTL clones directed against LB33‐MEL. A was obtained with blood lymphocytes collected from the patient in 1990. In vitro selection of melanoma cells that were resistant to these CTL clones indicated that at least five different antigens were recognized on LB33‐MEL. A by autologous CTL. Four of these antigens were found to be presented by HLA‐A28, B13, B44 and Cw6, respectively. The patient remained disease‐free until 1993 when a metastasis was detected and was used to obtain cell line LB33‐MEL. B. This cell line proved resistant to lysis by all the CTL clones directed against the LB33‐MEL. A cells and showed no expression of HLA class I molecules except for HLA‐A24. Using LB33‐MEL. B cells to stimulate blood lymphocytes collected from the patient in 1994 we derived CTL clones that lysed these cells. All these CTL clones recognized a new antigen presented by HLA‐A24. These results suggest that in patient LB33 the melanoma cells may have lost the expression of several HLA molecules under the selective pressure of an anti‐tumor CTL response.
T cell receptor γδ repertoire is skewed in cerebrospinal fluid of multiple sclerosis patients: molecular and functional analyses of antigen‐reactive γδ clones
Authors: Nick Sabine , Pileri Piero , Tongiani Stefania , Uematsu Yasushi , Kappos Ludwig , De Libero Gennaro 
Published: March 2007

AbstractTo study the relevance of γδ T cells in multiple sclerosis (MS) we analyzed the T cell receptor (TCR) γδ repertoire and the antigen reactivity of γδ clones isolated from cerebrospinal fluid (CSF). In T cell cultures derived from CSF we found an increased percentage of Vδ1+ cells as compared to peripheral blood of the same donors. Phenotypic analysis of cells from MS CSF with Vγ‐ and Vγ‐specific monoclonal antibodies (mAb) showed that the Vγ1 chain is most frequently associated with γ chains belonging to the VγI family. Sequence analysis of TCR genes revealed heterogeneity of junctional regions in both δ and γ genes indicating polyclonal expansion. γδ clones were established and some recognized glioblastoma, astrocytoma or monocytic cell lines. Stimulation with these targets induced serine esterase release and lymphokine expression characteristic of the TH0‐like phenotype. Remarkably, these tumor‐reactive γδ cells were not detected in the peripheral blood using PCR oligotyping, but were found in other CSF lines independently established from the same MS patient. Altogether, these results demonstrate that in the CSF there is a skewed TCR γδ repertoire and suggest that γδ cells reacting against brain‐derived antigens might have been locally expanded.
Induction of interleukin‐2 transcription by the hamster polyomavirus middle T antigen: a role for Fyn in T cell signal transduction
Authors: Brizuela Leonardo , Ulug Emin T. , Jones Margaret A. , Courtneidge Sara A. 
Published: March 2007

AbstractThe transforming protein of mouse polyomavirus, the mouse middle T antigen (MomT), and its counterpart in the hamster polyomavirus, the hamster middle T antigen (HamT), interact with a number of cellular proteins. Among these are members of the Src family of tyrosine kinases, the phosphatidylinositol 3‐kinase, the serine/threonine phosphatase PP2A and the adaptor protein Shc (in the case of MomT). However, both the relative affinity of these antigens for the members of the Src family and the tumor profile induced by their respective viruses are quite distinct. Particularly noteworthy are the preferential binding of Fyn by HamT and the induction of lymphoid malignancies by the hamster polyomavirus. Here we report that, when expressed in fibroblasts, HamT also associated with phospholipase Cγ (PLCγ), which led to an increased intracellular concentration of inositol‐1, 4, 5‐trisphosphate. We also show that expression of HamT in the mouse T cell line EL4 was sufficient to induce transcription from interleukin‐2 (IL‐2), NFAT and NFxB reporter constructs. The immunosuppressant FK506 as well as dominant negative alleles of Ras and Raf inhibited HamT‐induced IL‐2 transcription. This, together with the observation of NFAT responses, suggests that the action of HamT depended at least in part on the integrity of signal transduction pathways elicited by activated PLCγ. Furthermore, dominant negative Fyn but not the equivalent allele of Lck blocked HamT activation of IL‐2 transcription, while both Lck and Fyn dominant negative alleles blocked LT cell receptor‐mediated IL‐2 transcriptional activation. These results support the hypothesis that Fyn is involved in signal transduction events leading to IL‐2 transcriptional activation in T cells. Finally, the activation of IL‐2 transcription by HamT and not by MomT shown here parallels the ability of the hamster polyomavirus to induce lymphoid malignancies.
Reconstitution of a functional interleukin (IL)‐7 receptor demonstrates that the IL‐2 receptor γ chain is required for IL‐7 signal transduction
Authors: Ziegler Steven F. , Morella Karen K. , Anderson Dirk , Kumaki Noriko , Leonard Warren J. , Cosman David , Baumann Heinz 
Published: March 2007

AbstractThe interleukin (IL)‐2 receptor γ chain has recently been shown to be a component of the IL‐7 and IL‐4 receptors. Using a transient transfection assay and the trans‐activation of reporter gene constructs which are under the control of cytokine‐responsive promoter elements, we have studied signal transduction through the IL‐7 receptor (IL‐7R). The reporter gene expression was not stimulated by receptors that contained the cytoplasmic domain of the IL‐7R, either as intact IL‐7R or as part of a chimeric receptor. However, co‐expression of the IL‐7R with the IL‐2 receptor γ chain was able to stimulate gene activation. For maximal stimulation the intact cytoplasmic domains of each chain was required.
Functional gap junctions in thymic epithelial cells are formed by connexin 43
Authors: Alves Luiz Anastacio , de Carvalho Antonio Carlos Campos , Lima Elizabeth Obino Cirne , Souza Claudio Marcos Rocha E , Dardenne Mireille , Spray David Conover , Savino Wilson 
Published: March 2007

AbstractA multiparametric study was carried out to investigate the presence and possible role of communicating junctions in the thymus, particularly in the thymic epithelium, the major component of the thymic microenvironment. The presence of direct cell‐cell communication mediated by gap junctions was demonstrated in human and murine thymic epithelial cells (TEC) by means of in situ and in vitro immunohistochemical labeling as well as in vitro fluorochrome injection and double whole‐cell patch clamp experiments. Moreover, both immuno‐ and Northern blot studies revealed that the gap junction protein connexin 43 and its mRNA were present in TEC. Importantly, we showed that thymic endocrine activity, as ascertained by thymulin production, could be specifically downmodulated in vitro by a gap junction inhibitor, octanol. We also investigated the existence of gap junctions between TEC and thymocytes. In thymic nurse cells we were able to detect cell‐cell communication, although only a minor percentage of epithelial/thymocyte pairs were coupled in a given moment. In contrast, intercellular communication was not detected between cultured phagocytic cells of the thymic reticulum and the respective rosetting thymocytes. We suggest that gap junctions formed by connexin 43 may represent a novel (and rather cell type‐specific) pathway for intrathymic cellular communication, including TEC/TEC as well as possible TEC/thymocyte interactions.
Epitope mapping and functional properties of anti‐intercellular adhesion molecule‐3 (CD50) monoclonal antibodies
Authors: Bossy David , Buckley Christopher D. , Holness Claire L. , Littler Amanda J. , Murray Nicholas , Collins Ian , Simmons David L. 
Published: March 2007

AbstractIntercellular adhesion molecule‐3 (ICAM‐3, CD50), a member of the immunoglobulin gene superfamily, is a major ligand for the lymphocyte functionassociated antigen 1 (LFA‐1, CD18/CD11a) in the resting immune system and plays a role as a signaling and costimulatory molecule on T lymphocytes. In this study we have generated a large panel of anti‐ICAM‐3 monoclonal antibodies (mAb) and show that the biological effects of these antibodies are critically dependent on the epitope recognized. By using an adhesion assay employing COS cells expressing LFA‐1 binding to recombinant chimeric ICAM‐3‐Fc proteins (which overcomes the confounding effects of interleukocyte LFA‐1/ICAM binding events), we have been able to examine the effects of these antibodies in blocking IFA‐1/ICAM‐3 adhesion. Our data suggests that only a small minority of ICAM‐3 mAb, recognizing a distinct epitope, are able to mimic the effects of LFA‐1 binding to ICAM‐3. Moreover these antibodies are functionally distinct as defined by their costimulatory activity and ability to elicit interleukin‐2 production and cell proliferation in T lymphocytes.