bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Study on MHD Flow of Casson Fluid Due to Stretching Surface in Suspension of Dust and CNT and Graphene Nanoparticles: Entropy Generation
Authors: Ramanuja Mani 
Published: March 2024

Abstract
This study investigates the effects of the MHD flow via an exponentially extending surface of a Casson hybrid nanofluid made of graphene and carbon nanotubes. The directions of flow were subjected to the standard Lorentz force. With basic Casson nanofluid, we took CNTs and graphene into consideration. The velocity, temperature and concentration profiles are simulated using a mathematical model established under the flow suppositions by utilizing boundary exponentially layer surface approximations in equations using partial differentials (PDEs). The lie symmetry method was used to achieve a suitable performance of mathematical transformations. After applying the necessary transformations, partial differential equations (PDEs) were transformed into ordinary differential equations (ODEs). The dimensionless system was explained using a numerical with 4th-order Runge–Kutta method called bvp4c. Both tabular and depicted graphical representations were used to show the influence of relevant flow parameters on skin friction, Nusselt number, velocity, temperature, and concentration distributions. Furthermore, The Casson fluid parameter, magnetic field strength, Brownian motion, random motion, volume fraction, and radiation parameter cause the temperature profiles to rise at the surface can be observed. Also, increasing with Brownian motion, thermophoretic parameter, and radiation parameter increases the primary velocity while decreasing with Casson fluid parameter and magnetic field parameter. Furthermore,insight into system irreversibility and demonstrates actual system transit from a low entropy configuration to a high entropy configuration.
Exosome Therapy on Cisplatin-Induced Testicular Tissue Toxicity
Authors: YILDIZ Halime TOZAK , KALKAN Kübra Tuğçe , BAYDİLLİ Numan , GÖNEN Zeynep Burçin , MAT Özge CENGİZ , OKUR Eda , ÖNDER Gözde Özge , Prof Arzu YAY 
Published: March 2024

Abstract
Backround:
Cisplatin is a significant chemotherapy drug that has been used for different cancer types. The infertility and gonadotoxicity caused by metabolites resulting from cisplatin metabolism are two of the most serious side effects of cisplatin. Testicular dysfunction is generally caused by oxidative stress and autophagy that are induced by cisplatin. This study focused on potential exosomes' regenerative, antioxidant, and autophagy-regulating properties might be used to minimize testicular damage resulting from cisplatin.
Methods
For cisplatin toxicity, one dose of 7.5mg/kg was injected on first day. Exosom (80x106/100µl) was injected single dose on sixth day. To examine potential therapeutic effects of the exosome, tissue samples were taken on eighth day. For examination of testicular morphology, tissues were stained with Hematoxylin&Eosin. Sperm motility and number were examined. Autophagy markers and SF-1,StAR expressions, were evaluated immunohistochemistry. Oxidative stress, inhibin and testosterone levels were analysed.
Results
Cisplatin-induced damage caused to decrease in germinal epithelium, edema in interstitial areas, and degeneration in seminiferous tubules. Sperm motility and quality decreased. When compared to control groups, there was an increase in the expression of Beclin-1, p62, LC3-2, SF-1, and StAR. MDA activity increased,GSH-PX, SOD, and CAT activity decreased. Testosterone and inhibin levels decreased in serum. Tissue morphology was returned to normal, autophagy marker upregulation decreased, and SF-1 and StAR expressions increased in the group that received exosome, following cisplatin. There was a decrease in oxidative stress and increase in hormone levels
Conclusion
These findings suggest that the exosome may offer a promising approach to minimizing Cis-induced reproductive toxicity and tissue damage by reducing autophagy and improving oxidative stress.
Bibliometric and Visual Analysis of Fibrotic Pulmonary Sarcoidosis
Authors: WEI NAMIN , Fang Xinhua , Zhao Xuelong , Zeng Fengping , Yu Chenqian , Huyen Nguyen Thi Thanh , Li Feiyu , Chen Hongmei , Zhai Huaqiang 
Published: March 2024

Abstract
Background
Fibrotic pulmonary sarcoidosis (FPS) has a high mortality rate, but its pathogenesis is not clear and effective treatments are lackings. In recent years, numerous literature reviews have been published from various perspectives on FPS. However, there is still a lack of visual analysis and summary of its research status, hotspots, and development trends. Therefore, to fill this knowledge gap, this study conducted a bibliometric and visual analysis of the published literature on FPS.
Methods
A total of 962 relevant publications were extracted from the Web of Science Core Collection. CiteSpace was used to conduct a bibliometric analysis and draw knowledge maps from five dimensions: publication years and document types, scientific collaboration networks (authors, countries/territories and institutions), journals, references and keywords.
Results
Current FPS research exhibits steady growth, capturing widespread attention. Noteworthy authors include Bargagli E, Baughman RP, Valeyre D, Raghu G, and Hunninghake GW. USA, Italy, Germany, England, and Netherlands demonstrate relatively mature research in this field. Three influential research institutions, namely Royal Brompton Hospital (England), Imperial College London (England) and University of California System (USA), stand out in this field. Important journals include American Journal of Respiratory and Critical Care Medicine, European Respiratory Journal, Chest, Thorax and Respiratory Medicine. These journals primarily focus on the evaluation, clinical and immunological characteristics, and treatment of FPS. Current hot research topics mainly include FPS-relevant diseases (interstitial lung disease, idiopathic pulmonary fibrosis and pulmonary fibrosis), complications (pulmonary hypertension, chronic obstructive pulmonary disease, and lung cancer), commonly used treatments (bronchoalveolar lavage), and biomarkers (YKL-40). Diagnosis, treatment (clinical trial drug studies), cardiac sarcoidosis, and quality of life are currently in an explosive stage and will be the focus of future research.
Conclusion
This research provides useful information for the study of FPS, including potential collaborators, research status of various countries and institutions, distribution and knowledge structure of journals, as well as research status and hotspots, providing a reference for future broader and deeper research.
Patterns of Posttraumatic Stress Disorder and Posttraumatic Growth Among Employees After the Tianjin Explosion in China: A Latent Profile Analysis
Authors: Huang Yijin , Chen Yaru , Zhu Zhengqing , Lv Meixuan , Liu Zhengkui 
Published: March 2024

Abstract
Background: Posttraumatic stress disorder(PTSD) and posttraumatic growth (PTG) often coexist in survivors of traumatic events. In this study, latent profile analysis was used to investigate the coocurrence patterns of PTSD and PTG among a sample of employees who survived an explosion in the Tianjin Binhai New Area on August 12, 2015. We aimed to determine whether profiles could be affected by specific predictors.
Method: Latent profile analysis was used to examine cooccurrence patterns of self-reported PTSD and PTG in a sample of 2,456 employees who survived the Tianjin Binhai New Area explosion.
Results: Four distinct profiles were identified mild PTSD/mild PTG group, mild PTSD/high PTG group, mild PTSD/medium PTG group, high PTSD/medium PTG group. The classification was predicted by several variables, such as depression, resilience and issues related to trauma exposure.
Conclusion: Our findings contribute to knowledge about the cooccurrence patterns of PTSD and PTG and provide guidance for future clinical practice to identify individuals at high risk for effective interventions.
The Impact of Relaxing the Requirements for Dyspeptic Symptom Onset Frequency and Duration in Rome IV Criteria on the Diagnosis and Symptom Pattern of Functional Dyspepsia
Authors: Wang Jinsheng , Wu Junhao , Hou Xiaohua , Zhang Lei 
Published: March 2024

Abstract

Background
The Rome IV criteria for functional dyspepsia (FD) has strict requirements for symptom frequency and onset duration, making it challenging to identify patients with broadly defined FD in clinical practice.
Aims
This study aimed to investigate the impact of relaxing the Rome IV criteria on the diagnosis and symptom pattern of FD.
Methods
A cross-sectional, multi-center study was conducted involving 2935 consecutive broadly defined FD patients with no positive findings on upper GI endoscopy and routine examinations. Questionnaires were used to collect demographic and upper gastrointestinal symptom data. Symptom pattern was compared between Rome IV criteria defined FD patients and those defined by relaxed Rome IV criteria.
Results
Only 22.2% of broadly defined FD patients rigorously fulfilled Rome IV criteria. No significant difference was found for all symptoms mentioned in this study, as well as dyspeptic symptom severity and onset frequency, between broadly defined FD who fulfilled Rome IV criteria but had a duration of 3–6 months and Rome IV criteria defined FD. Broadly defined Postprandial Distress Syndrome (PDS) patients who fulfilled the Rome IV criteria but had a symptom frequency of 1–2 days per week had significantly lower symptom severity, but similar postprandial symptom characteristics compared to those defined by the Rome IV criteria.
Conclusion
A symptom duration criterion of 3 months may be sufficient for diagnosing FD in China. Reducing the symptom onset frequency to no less than 1 day per week in the Rome IV criteria for PDS does not affect its postprandial symptom characteristics.
Transforming Driver Management in Enterprises in the Name of Digitization: A Flutter- Powered Approach
Authors: Özkurt Cem 
Published: March 2024

Abstract
This study addresses the inefficiencies inherent in traditional driver management methods, shedding light on the specific challenges that impede operational effectiveness. The identified problems include cumbersome paper-based processes and outdated systems. To comprehensively tackle these issues, the research introduces specific research questions and a methodology, emphasizing the need for a digital transformation in driver management. Delving deeper into the intricacies of the subject, this study not only articulates the prevalent challenges of conventional methods but also formulates specific research questions to guide the investigation. The methodology employed involves a meticulous examination of operational processes and constraints, highlighting potential threats to validity and ensuring a robust analysis. By doing so, the research aims to provide a nuanced understanding of the problems and opportunities in driver management. As a part of the transformative shift advocated in this study, the integration of Flutter is introduced as a pivotal solution. Beyond a mere technological upgrade, Flutter is positioned as a paradigm shift, addressing identified threats to validity and offering a holistic and efficient solution to the intricate demands of driver management processes. The study concludes by emphasizing the multifaceted benefits of this digital transformation, ranging from enhanced workflow optimization to the establishment of a driver-centric platform. Also the application exhibited substantial improvements in key operational areas, resulting in significant percentages of enhancement. Unnecessary fuel consumption saw a notable reduction of approximately 15%, indicating a substantial improvement in fuel efficiency. The optimization features of the application contributed to a 20% decrease in irregular employee arrival times, highlighting its efficacy in improving scheduling and punctuality.
Immune transcriptomic profile in adult female pigs: dominance status has more influence than environmental enrichment
Authors: Lopes Mariana Mescouto , Clouard Caroline , Vincent Annie , Thomas Françoise , Hérault Frédéric , Louveau Isabelle , Resmond Rémi , Jammes Hélène , Merlot Elodie 
Published: March 2024

Abstract

Background
Assessing animals’ affective states is crucial for evaluating the welfare of farm animals, yet practical tools are lacking. In this study, we tested whether the peripheral blood mononuclear cell (PBMC) transcriptome can be used to show variations in sows’ affective state. To do this, we compared animals whose emotional states were assumed to differ due to their lives in more or less enriched environments and to their different dominance statuses. Sows (n = 71) were housed in conventional (C) or enriched (E) environments from gestation day 0 (G0) until three weeks before farrowing (G105), after which they were transferred to conventional maternity rooms. On G98, saliva and hair were collected for cortisol measurement. From G99 to G103, behavioral analyses were conducted, and dominance hierarchy was evaluated. Blood samples were collected for PBMC transcriptome analysis on G98 and on lactation day 12 (L12).
Results
Both environmental enrichment (EE) and dominance status influenced cortisol and variables related to social and exploratory behavior, indicating an influence on sows’ affective states. While EE affected only a few genes (31 differentially expressed genes (DEGs) in G98, dominance status significantly impacted the PBMC transcriptome (449 DEGs in G98). Compared with subordinate sows (SUB), dominant (DOM) sows exhibited upregulated inflammatory genes, downregulated B-cell activation, and upregulated plasma cell function. In groups of sows, dominance status is partly related to sow parity, and we compared the effect of dominance with that of parity. Some similar DEGs emerged when comparing different parity animals (high-parity (HP) vs. low-parity (LP); 542 DEGs on G98, 180 in common with dominance-impacted genes), indicating that some effects of dominance on the transcriptome were in fact more due to age or reproductive cycles than to dominance itself. EE and dominance effects appeared relatively short-term, as DEG numbers decreased on L12 (four DEGs for E vs. C, 25 for DOM vs. SUB).
Conclusions
Both EE and dominance status influenced sows’ affective states; however, dominance status exerted a more pronounced influence on sows’ PBMC transcriptome than did environmental enrichment. In particular, dominance status modulated genes associated with B cells and plasma cell functions.
Artificial Neural Networks in the Perception of Genetic Differentiation Caused by Migration
Authors: Pigaiani Maria Eduarda Farias , Oliveira Marciane Silva , Vidon Letícia Rodrigues , Oliveira Alessandro Marques , Cruz Cosme Damião 
Published: March 2024

Abstract
Understanding genetic diversity is exceptionally important in order to ensure variability and viability among populations of the same species. Genetic diversity among populations is a consequence of different evolutionary mechanisms that act on them, resulting in different genotypic and allelic frequencies between generations and their future generations; among the different evolutionary mechanisms is migration or gene flow. Self-Organizing Maps (SOM) is an interesting tool to organize and map populations, in addition to highlighting the effects of genetic diversity caused by different evolutionary mechanisms, including migration. The objective of this work was to verify the effects of migration along the generations, analyzing them according to the Conventional Techniques of Biostatistics - Nei, Hedrick and Tocher Cluster Statistics - and, later, to analyze if the self-organizing maps are able to map the effects caused by it. This way, base populations were generated in Hardy-Weinberg equilibrium with 1000 individuals each, 100 codominant diallelic loci, and allelic frequencies equal to p = q = 0.50, which were used to simulate the effects of migration. The simulation is justified because it allows for the control of the generated effects. The SOM were able of capturing the diversity patterns generated for different quantities of migrants over different generations in various replicates. We concluded that SOMs are sensitive to detecting genetic variability and provide additional information on population organization.
Lithium Perborate-Based Composite Polymer Electrolytes for All-Solid-State Lithium-Ion Batteries: Performance Enhancement and Stability
Authors: Pandurangan Ilakkiya , Sathiasivan Kiruthika , Aarimuthu Gayathri , Kannadasan Mahalakshmi , Balakrishnan Muthukumaran 
Published: March 2024

Abstract

A rapid rise in the development of portable electronic devices and telecommunication technologies has led to an ever-growing demand for high safety, large energy density and cost effective systems for storing energy. Rechargeable all-solid-state lithium-ion batteries are extremely productive without compromising performance. In this study, Garnet-type Li7La3Zr2O12 (LLZO), filler was prepared employing the sol-gel method. That follows, the high-performance poly(ethylene oxide)/ Lithium perborate (LiBO3)/LLZO composite solid polymer electrolyte was fabricated using a simple solution-casting technique. The morphology and composition of the prepared CSPE (composite solid polymer electrolyte) (PEO-LiBO3-LLZO) were investigated using X-ray diffraction and scanning electron microscopy in addition to other physicochemical characterization techniques. The composite solid polymer electrolyte exhibits a maximum ionic conductivity of 2.4 x 10− 4 S cm− 1 with LLZO filler and a wide electrochemical window of 4.6 V vs. Li+/Li. The prepared electrolyte reveal good electrochemical efficiencies with elevated discharge capacity of 73.2 mAhg− 1 and excellent faradaic efficiency of 98% since 100 cycles. Based on these results, the prepared composite solid polymer electrolyte furnish an auspicious methodology for the advancement of high-performing rechargeable all-solid-state lithium-ion batteries.
Enhancement of MAPb0.75Sn0.25I3 solar cell efficiency by doping HTL and ETL layers
Authors: Abdallaoui Doua , Meftah Afak , Sengouga Nouredine , Abdallaoui Maroua , Labed Madani 
Published: March 2024

Abstract

Numerical simulation of a lead-tin perovskite (MAPb0.75Sn0.25I3) solar cell was conducted. The simulation was validated against measurements (Li et al. J Mater Chem C Mater 5 (2017) 2360–2367. https://doi.org/10.1039/C6TC05325D) and the photovoltaic conversion efficiency (PCE) closely matched the measured value, 12.19 ≈ 12.08%. Subsequently, optimization strategies to enhance the SC performance were pursued. Doping hole and electron transport layers (HTL, ETL) with various elements as well as adjusting HTL, ETL, and perovskite thicknesses have improved PCE and carriers’ extraction. These optimizations led to an enhancement in PCE to 12.93%. Further improvements using Copper oxide (Cu2O) as HTL yielded a PCE of 13.38%. Doping Cu2O with Tellurium pushed PCE to 14.73%. Copper doping of Zinc Oxide outperformed other ETLs and increased PCE to 15.33%. Overall, these findings represent significant strides in advancing the design of perovskite solar cells, providing valuable insights for further enhancements in photovoltaic conversion efficiency.
BISMUTH SUBSALICYLATE REVERSES HIGH FAT DIET-INDUCED INCREASE IN PORTAL VENOUS FLOW
Authors: Birg Aleksandr , Coffman Cristina , Rumsey Kellin , Lin Henry , Kanagy Nancy 
Published: March 2024

Abstract

In animal studies, a high-fat diet (HFD) is associated with fatty liver disease and vascular complications characterized by hyperdynamic circulation. The underlying mechanism for these hemodynamic changes is not known. Hydrogen sulfide (H2S) is a gaseous signaling molecule that plays several roles including that of a vasodilator in the peripheral vascular system. H2S is produced by both mammalian cells and sulfate reducing bacteria (SRB). SRB in the gut are known to convert hydrogen, a by-product of bacterial fermentation, to H2S. Bismuth subsalicylate (BSS) lowers the availability of luminal H2S by binding directly to this gas in the gut lumen. In this study, we tested the hypothesis that a high fat diet may increase portal venous blood flow in a BSS-reversible fashion in rats (n = 8/group) fed one of 4 diets for 8 weeks: HFD, HFD + BSS, standard diet (SDD) and SDD + BSS. Portal venous blood flow was measured in laparotomized animals using a perivascular ultrasonic probe. To directly test the effect of H2S, portal venous blood flow was also compared before (baseline) and after infusing NaHS, a donor of H2S, into the jejunum. We found that baseline rates of portal venous blood flow were significantly greater in the HFD group [23.41 ± 0.4mL/min, p < 0.05] than SDD group [17.48 ± 0.2 mL/min], HFD + BSS [17.95 ± 0.3mL/min] or SDD + BSS [14.49 ± 0.2mL/min]. H2S donor increased portal venous blood flow significantly more in the HFD group [6.1 ± 0.26mL/min, p < 0.05] when compared to SDD group [1.88 ± 0.18mL/min], HFD + BSS [2.00 ± 0.40mL/min] or SDD + BSS [3.45 ± 0.34mL/min). qPCR using primers targeting the dissimilatory sulfite reductase beta-subunit (dsrB) of SRB ([NiFe] hydrogenase gene fragment), the phyla Firmicutes and Bacteroidetes showed no difference between groups in the distal small intestine. The liver enzymes AST and ALT were significantly elevated in the HFD group than HFD + BSS, SDD and SDD + BSS (p = 0.044, 0.011, respectively). In conclusion, an increase in portal venous blood flow consistent with a hyperdynamic circulation was observed in HFD-fed animals with a further increase induced by infusion of NaHS. In HFD-fed animals, the increase in portal venous blood flow at baseline and the further increase following NaHS infusion were both reversed by H2S-binding BSS administered to the gut supporting the conclusion that increased portal venous blood flow in HFD-fed animals was driven by gut bacteria-derived H2S.
Linear Low-Density Polyethylene Nanocomposites Reinforced by Multi-Walled Carbon Nanotubes Functionalized with Hyperbranched Poly(ether-ketone)s
Authors: Kang Hyo Seon , Yoon Seo Jeong , Baek Jaehoon , Jeon In-Yup 
Published: March 2024

Abstract

Multi-walled carbon nanotubes (MWCNT) functionalized with hyperbranched poly(ether-ketone)s (H-f-M) were prepared through in-situ polymerization and Friedel-Crafts acylation between MWCNT and 3,5-diphenoxy benzoic acid. The resultant H-f-M displayed very good dispersion and compatibility with the LLDPE matrix due to the hyperbranched poly(ether-ketone)s functional groups. H-f-M@LLDPE_X nanocomposites prepared through a solution mixing method with the H-f-M as a filler, exhibited exceptional performance, particularly in terms of mechanical properties and thermal stability. Among them, the H-f-M@LLDPE_2 nanocomposites stood out as the most promising because they demonstrated a remarkable increase in tensile strength, Young's modulus, tensile toughness, and elongation, by 39.0%, 32.7%, 48.1%, and 18.5%, respectively, compared to the pure LLDPE. Given its excellent performance and straightforward functionalization, the H-f-M with hyperbranched polymers shows promise as a novel reinforcing filler for polymer applications.