bluuebunny/crossref_metadata_2025_split huggingface dataset:
Albumin‐bound lipids induce free cytoplasmic calcium oscillations in human osteoblast‐like cells
Authors: Tsai Jon A. , Lagumdzija Alena , Stark André , Kindmark Henrik 
Published: January 2006

Abstract[Ca2+]i oscillations were found in human osteoblast‐like cells (hOB cells) exposed to high‐lipid bovine serum albumin (BSA), but not when exposed to low‐lipid BSA. These [Ca2+]i oscillations were inhibited by heptanol and suramin, which implies that gap junctions and purinergic signalling may be important for these [Ca2+]i oscillations. The high‐lipid BSA preparation that was used contains arachidonic acid. [Ca2+]i oscillations could be induced by low lipid albumin with arachidonic acid added. The albumin‐bound lipids were also important for osteoblast growth since DNA synthesis and the total cell protein content was higher in hOB cells exposed to high‐lipid BSA. The effect of arachidonic acid on hOB cell proliferation was bone‐donor dependent; both stimulatory and inhibitory effects were observed. The physiological importance of albumin‐bound lipids is unclear; given that albumin has only minimal contact with osteoblasts under normal conditions. Only when bone capillaries are disrupted, e.g. during a fracture, would significant amounts of albumin reach osteoblasts. Albumin‐bound lipids could therefore contribute to stimulation of osteoblast proliferation during fracture healing. Copyright © 2006 John Wiley & Sons, Ltd.
Acute effects of isolated and combined L‐alanine and L‐glutamine on hepatic gluconeogenesis, ureagenesis and glycaemic recovery in experimental short‐term insulin induced hypoglycaemia
Authors: Gazola V. A. F. G. , Garcia R. F. , Curi R. , Pithon‐Curi T. C. , Mohamad M. S. , Hartmann E. M. , Barrena H. C. , Bazotte R. B. 
Published: January 2006

AbstractThe acute effects of isolated and combined L‐alanine (L‐Ala) and L‐glutamine (L‐Gln) on liver gluconeogenesis, ureagenesis and glycaemic recovery during short‐term insulin‐induced hypoglycaemia (IIH) were investigated. For this purpose, 24‐h fasted rats that received intraperitoneal injection of regular insulin (1.0 U/Kg) were investigated. The control group (COG group) were represented by rats which received saline. The studies were performed 30 min after insulin (IIH group) or saline (COG group) injection. Livers from IIH and COG groups were perfused with basal or saturating levels of L‐Ala, L‐Gln or L‐Gln + L‐Ala (L‐G + L‐A). The production of glucose, urea, L‐lactate and pyruvate in livers from IIH and COG group were markedly increased (p < 0.001) when perfused with saturating levels of L‐Ala, L‐Gln or L‐G + L‐A compared with basal levels of the same substrates. In addition, livers from IIH rats showed greater ability in producing glucose and urea from saturating levels of L‐Ala compared with L‐Gln or L‐G + L‐A. In agreement with these results, the oral administration of L‐Ala (100 mg/kg) promoted better glycaemic recovery than L‐Gln (100 mg/kg) or the combination of L‐G (50 mg/kg) + L‐A (50 mg/kg). It can be concluded that L‐Ala, but not L‐Gln or L‐G + L‐A could help glycaemic recovery by a mechanism mediated, partly at least, by the increased gluconeogenic and ureagenic efficiency of L‐Ala. Copyright © 2006 John Wiley & Sons, Ltd.
A comparative study of the effects of molsidomine and 3‐morpholinosydnonimine on the redox status of rat erythrocytes and reticulocytes
Authors: Marković Snežana D. , Vukajlović Miroslava Dj. , Ognjanović Branka I. , Štajn Andraš Š. , Žikić Radoslav V. , Saičić Zorica S. , Radojičić Ratko M. , Jones David R. , Spasić Mihajlo B. 
Published: January 2006

AbstractAfter enzymic biotransformation, molsidomine (MO) acts via the metabolite 3‐morpholinosydnonimine (SIN‐1) through spontaneous liberation of nitric oxide (NO) and superoxide (O). The aim of this study was to compare the effects of MO and its active metabolite SIN‐1 on the redox status of rat erythrocytes and reticulocytes. Rat erythrocyte as well as reticulocyte‐rich red blood cell (RBC) suspensions were aerobically incubated (2 h, 37°C) without (control) or in the presence of different concentrations of MO or SIN‐1. In rat erythrocytes, biotransformation of MO resulted in the production of NO and nitroxyl (NO−). Endogenous superoxide anion (O) participated in peroxynitrite generation. SIN‐1 simultaneously liberated NO and O, which formed peroxynitrite (at least in part), but the liberated NO predominantly reacted with haemoglobin, forming methaemoglobin in erythrocytes. In reticulocytes, MO and SIN‐1 caused an increase in the levels of both nitrite and 3‐nitrotyrosine (an indicator of peroxynitrite), whereas they decreased the level of O. In reticulocytes, MO was metabolized into SIN‐1 which led to the generation of NO, which reacted with O (endogenous or exogenous) forming reactive nitrogen species. In conclusion, there are two metabolic pathways for MO biotransformation: one causing NO and NO− generation predominantly in erythrocytes and the other, via SIN‐1 metabolism, in reticulocytes. The main difference between the action of MO and SIN‐1 was that the latter caused oxidative damage in RBCs. Copyright © 2006 John Wiley & Sons, Ltd.
Protective effects of melatonin and indole‐3‐propionic acid against lipid peroxidation, caused by potassium bromate in the rat kidney
Authors: Karbownik Małgorzata , Stasiak Magdalena , Zygmunt Arkadiusz , Zasada Krzysztof , Lewiński Andrzej 
Published: January 2006

AbstractPotassium bromate (KBrO3) is classified as a carcinogenic agent. KBrO3 induces tumors and prooxidative effects in kidneys. Melatonin is a well known antioxidant and free radical scavenger. Indole‐3‐propionic acid (IPA), an indole substance, also reveals antioxidative properties. Recently, some antioxidative effects of propylthiouracil (PTU)—an antithyroid drug—have been found. The aim of the study was to compare protective effects of melatonin, IPA, and PTU against lipid peroxidation in the kidneys and blood serum and, additionally, in the livers and the lungs, collected from rats, pretreated with KBrO3. Male Wistar rats were administered KBrO3 (110 mg/kg b.w., i.p., on the 10th day of the experiment) and/or melatonin, or IPA (0.0645 mmol/kg b.w., i.p., twice daily, for 10 days), or PTU (0.025% solution in drinking water, for 10 days). The level of lipid peroxidation products—malondialdehyde + 4‐hydroxyalkenals (MDA + 4‐HDA)—was measured spectrophotometrically in thyroid homogenates. KBrO3, when injected to rats, significantly increased lipid peroxidation in the kidney homogenates and blood serum, but not in the liver and the lung homogenates. Co‐treatment with either melatonin or with IPA, but not with PTU, decreased KBrO3‐induced oxidative damage to lipids in the rat kidneys and serum. In conclusion, melatonin and IPA, which prevent KBrO3‐induced lipid peroxidation in rat kidneys, may be of great value as protective agents under conditions of exposure to KBrO3. Copyright © 2006 John Wiley & Sons, Ltd.
Medication and suggestion in the treatment of depression
Authors: Kirsch Irving 
Published: January 2006

AbstractConcerns that SSRIs might increase suicide rates among depressed patients raise the question of whether the benefits of these medications warrant the risk they pose. Meta‐analyses of published and unpublished clinical trials reveal that the benef its of antidepressants over placebo are minimal. Most trials sponsored by the pharmaceutical company fail to show a significant advantage of SSRIs over inert placebo. Documents obtained from the US Food and Drug Administration (FDA) reveal an explicit decision to keep this information from the public and from prescribing physicians. The data suggest that psychotherapy, especially augmented by hypnosis, may be a better choice for depressed individuals. Copyright © 2005 British Society of Experimental and Clinical Hypnosis
Effects of different types of preparatory information on attitudes toward hypnosis
Authors: Capafons Antonio , Cabañas Sonia , Alarcón Ana , Espejo Begoña , Mendoza M. Elena , Chaves John F. , Monje Antonio 
Published: January 2006

AbstractThis paper examines how attitudes of initially reluctant subjects towards hypnosis are influenced by three different approaches to introducing the topic. Participants (N = 90) were assigned to one of three experimental conditions: minimal information, cognitive‐behavioural information and trance information. All three groups showed positive changes in attitudes toward hypnosis. Contrary to our expectations, positive attitudinal changes were not diminished for subjects exposed to trance information. Groups given trance and cognitive‐behavioural explanations demonstrated significantly greater collaboration compared to the control group. No differences in hypnotic suggestibility were obtained. Copyright © 2005 British Society of Experimental and Clinical Hypnosis
Suggestibility of the Chinese as revealed by the creative imagination scale
Authors: Kai‐ching Yu Calvin 
Published: January 2006

AbstractThe current aim of the study is to provide a preliminary view of the suggestibility of Chinese people. Direct hypnotic experience was examined by giving a widely used suggestibility measure, the ‘Creative Imagination Scale’, to 90 volunteer subjects who were randomly drawn from a college in Hong Kong. The Creative Imagination Scale is thought to be a clinically useful assessment, which may reveal some implications for the applications of hypnosis in the Chinese culture. The current results indicated that the distribution of the suggestibility scores of the current Chinese sample tended to be more centralized than the Western counterpart, and that there were some cultural differences in the psychometric features and preferred modalities. By and large, the prospect of using hypnosis in the Chinese population is positive in view of their relatively good susceptibility to hypnotic suggestions. Copyright © 2005 British Society of Experimental and Clinical Hypnosis
Quality of life and mood changes in metastatic breast cancer after training in self‐hypnosis or Johrei: a short report
Authors: Laidlaw Tannis , Bennett Bryan M. , Dwivedi Prabudha , Naito Akira , Gruzelier John 
Published: January 2006

AbstractThis is a small pilot study using two psychological interventions aimed at maintaining health and well‐being in women with metastatic breast cancer. Out of 100 women deemed eligible, 37 were randomly assigned to 4 weeks of training in self‐hypnosis or to a Japanese healing method, Johrei, or to a wait‐list control condition for three months. Participants were examined with quality of life and mood scales on two occasions, prior to training and again three or more months later. Most data were able to be collected on 14 participants. Following both interventions, patients were more composed and less anxious than controls. Hypnosis training increased and Johrei patients maintained energy levels. There was a positive change in anxiety levels and a general increase in other mood scores. Such results are relevant to a better quality of life. In conclusion, the participants in this pilot study appear to have benefited by not only maintaining but also often increasing their energy levels and decreasing anxiety and other debilitating emotional states that influence quality of life, health and well‐being. Copyright © 2005 British Society of Experimental and Clinical Hypnosis
Hypnotic imagery — therapy for a hives patient with alexithymic characteristics
Authors: Suzuki Tsunemoto 
Published: January 2006

AbstractThis is a case study of an alexithymic female patient with hives who was treated with hypnotic imagery‐therapy. The patient initially exhibited a deficit in imagination, but with continued treatment her imagination during hypnosis improved. She also developed the ability to verbally express emotions, not only in the hypnotic state, but also in the waking state. In addition, as a result of internalizing the therapist's suggestions of relaxation, the therapy increased the patient's capacity for self‐care. It is suggested that hypnotic imagery‐therapy is effective in decreasing alexithymic characteristics. Copyright © 2005 British Society of Experimental and Clinical Hypnosis
Application of cognitive‐behavioural hypnotic treatment for anxiety management in the Chinese
Authors: Kai‐ching Yu Calvin 
Published: January 2006

AbstractThis paper reports a treatment group, including four Chinese participants, run for general anxiety management with the aid of hypnosis, principally derived from the three‐session stress management programme devised by the Hypnosis Unit of University College London. Instead of exploring the deep history in relation to the aetiology of the present problems, this group focussed on intervening in the vicious cognitive‐behavioural‐physiological cycle of anxiety problems. A total of three sessions spread over three weeks was undertaken, including brief assessments of anxiety, psychoeducation of stress and of the use of hypnosis, hypnotic intervention, and counselling. Hypnosis was utilized as an adjunct to counselling, ego‐strengthening, stress management, and in facilitating cognitive restructuring. Both formal assessments and subjective reports reflected a significant improvement in management of stress. On the whole, as measured by the Client Satisfaction Questionnaire, the participants were satisfied and cherished the hypnotherapeutic experience. This paper demonstrates the possible application of hypnosis in the Chinese population as well as the efficacy of hypnosis for anxiety management. Copyright © 2005 British Society of Experimental and Clinical Hypnosis
Synthesis and Structural Properties of Nd3‐xYxFe27.5Ti0.8 Mo0.4 (0 ≤ x ≤ 1.8) and Nd3‐x′Yx′Fe27.8Mo1.2 (0 ≤ x′ ≤ 2.8) Intermetallic Compounds.
Authors: Han S. B. , Lv J. Y. , Liu X. F. , Peng J. , Chen D. F. , Xue Y. J. , Li J. H. , Hu Z. B. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Bioisosteric Phentolamine Analogues as Potent α‐Adrenergic Antagonists.
Authors: Hong Seoung‐Soo , Bavadekar Supriya A. , Lee Sang‐Il , Patil Popat. N. , Lalchandani S. G. , Feller Dennis R. , Miller Duane D. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
High‐Pressure Organic Chemistry. Part 29. High‐Pressure‐Promoted Uncatalyzed Ketalization of Ketones and Oxy‐Michael/Ketalization of Conjugated Enones.
Authors: Kumamoto Koji , Ichikawa Yoshiyasu , Kotsuki Hiyoshizo 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Heterogenization of Shibasaki′s Binol/La Catalyst for Enantioselective Epoxidation of α,β‐Unsaturated Ketones with Multitopic Binol Ligands: The Impact of Bridging Spacers.
Authors: Wang Xingwang , Shi Lei , Li Mingxing , Ding Kuiling 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Bis(pyrrol‐2‐yl)arylenes from the Tandem Bidirectional Addition of Vinyl Grignard Reagent to Aryl Diesters.
Authors: Hansford Karl A. , Perez Guarin Sergio Andres , Skene W. G. , Lubell William D. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Metal‐Free Catalytic Aerobic Aromatization of Hantzsch 1,4‐Dihydropyridines by N‐Hydroxyphthalimide.
Authors: Han Bing , Liu Qiang , Liu Zhengang , Mu Ruizhu , Zhang Wei , Liu Zhong‐Li , Yu Wei 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Biological Activity of Some 3‐Imidazo[1,2‐a]pyridin‐2‐yl‐chromen‐2‐one and 3‐Indolizin‐2‐yl‐chromen‐2‐one.
Authors: Kumar P. Vijaya , Rao V. Rajeswar 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Facile Synthesis of Substituted Dihydro‐1,4‐dithiins and ‐1,4‐dithiepins from α‐Oxo Ketene Cyclic Dithioacetals.
Authors: Dong Dewen , Sun Ran , Yu Haifeng , Ouyang Yan , Zhang Qian , Liu Qun 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Alternative Routes to the Pyrazolo[4,3‐e][1,2,4]triazolo[1,5‐c]pyrimidine System.
Authors: Tyurin R. V. , Vorob'ev E. V. , Minyaeva L. G. , Krasnikov V. V. , Mezheritskii V. V. 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Heterocyclization of Imidates with 3‐Alkyl‐5‐amino‐1‐phenyl‐1,2,4‐triazoles: Synthesis of New Triazolotriazines
Authors: Chabchoub Fakher , Rekik Awatef , Salem Mansour 
Published: January 2006

AbstractFor Abstract see ChemInform Abstract in Full Text.
Phosphorothioate Analogues of Alkyl Lysophosphatidic Acid as LPA3Receptor‐Selective Agonists
Authors: Qian Lian , Xu Yong , Simper Ted , Jiang Guowei , Aoki Junken , Umezu‐Goto Makiko , Arai Hiroyuki , Yu Shuangxing , Mills Gordon B. , Tsukahara Ryoko , Makarova Natalia , Fujiwara Yuko , Tigyi Gabor , Prestwich Glenn D. 
Published: January 2006

AbstractThe metabolically stabilized LPA analogue 1‐oleoyl‐2‐O‐methyl‐rac‐glycerophosphorothioate (OMPT) was recently shown to be a potent subtype‐selective agonist for LPA3, a G‐protein‐coupled receptor (GPCR) in the endothelial differentiation gene (EDG) family. Further stabilization was achieved by replacing the sn‐1 O‐acyl group with an O‐alkyl ether. A new synthetic route for the enantiospecific synthesis of the resulting alkyl LPA phosphorothioate analogues is described. The pharmacological properties of the alkyl OMPT analogues were characterized for subtype‐specific agonist activity using Ca2+‐mobilization assays in RH7777 cells expressing the individual EDG family LPA receptors. Alkyl OMPT analogues induced cell migration in cancer cells mediated through LPA1. Alkyl OMPT analogues also activated Ca2+release through LPA2activation but with less potency than sn‐1‐oleoyl LPA. In contrast, alkyl OMPT analogues were potent LPA3agonists. The alkyl OMPTs1and3induced cell proliferation at submicromolar concentrations in 10T 1/2 fibroblasts. Interestingly, the absolute configuration of the sn‐2 methoxy group of the alkyl OMPT analogues was not recognized by any of the LPA receptors in the EDG family. By using a reporter gene assay for the LPA‐activated nuclear transcription factor PPARγ, we demonstrated that phosphorothioate diesters have agonist activity that is independent of their ligand properties at the LPA‐activated GPCRs. The availability of new alkyl LPA analogues expands the scope of structure–activity studies and will further refine the molecular nature of ligand–receptor interactions for this class of GPCRs.
Acute and delayed nausea and emesis control in pediatric oncology patients
Authors: Holdsworth Mark T. , Raisch Dennis W. , Frost Jami 
Published: January 2006

AbstractBACKGROUNDTo the authors' knowledge there is little information available regarding the effectiveness of standard antiemetic therapy among cancer patients who receive emetogenic chemotherapy in clinical practice, especially in the pediatric population. The current study was undertaken to determine the effectiveness of standard antiemetic interventions among children receiving emetogenic chemotherapy.METHODSThe authors conducted a retrospective review of antiemetic surveys for children who received emetogenic chemotherapy. Patients and/or their parents were surveyed for acute and delayed nausea and emesis after each course of emetogenic chemotherapy. The survey consisted of validated measures of the severity of nausea and emesis. Complete protection (CP) rates were calculated for each chemotherapy regimen during both the acute and delayed phases and also by gender and age group (ages birth–3 yrs, 4–11 yrs, and 12–20 yrs). Antiemetic therapy consisted of intravenous ondansetron administered once daily during chemotherapy either alone (for moderately emetogenic chemotherapy) or in combination with dexamethasone (for severely emetogenic chemotherapy).RESULTSIn total, 224 different patients completed 1256 surveys. CP from both acute and delayed nausea and emesis was more likely in the children ages birth–3 years than in older children. For moderately emetogenic regimens, nausea and emesis in the acute and delayed phases were controlled well. Among severely emetogenic chemotherapy regimens, 7 of 12 different regimen types had CP rates < 50% in either the acute phase or the delayed phase. CP rates were particularly low for cisplatin‐based and cyclophosphamide‐based regimens.CONCLUSIONSNausea and emesis remain significant problems among children who receive emetogenic chemotherapy. CP rates were associated significantly with patient age, and higher rates were observed among very young children. Cancer 2006. © 2006 American Cancer Society.
Cytoprotection of beta cells: rational gene transfer strategies
Authors: McCabe Cillian , Samali Afshin , O'Brien Timothy 
Published: January 2006

AbstractGene transfer to pancreatic islets may prove useful in preventing islet cell destruction and prolonging islet graft survival after transplantation in patients with type 1 diabetes mellitus (T1DM). Potentially, a host of therapeutically relevant transgenes may be incorporated into an appropriate gene delivery vehicle and used for islet modification. An increasing understanding of the molecular pathogenesis of immune‐mediated beta cell death has served to highlight molecules which have become suitable candidates for promoting islet cell survival in the face of oxidative stress. This review aims to give an overview of some conventional gene transfer strategies aimed at promoting islet cell survival in the face of cytokine onslaught. These strategies target three aspects of islet cell physiology: redox status and antioxidant defence, anti‐apoptotic gene expression and mediators of cytokine signal transduction pathways. Copyright © 2006 John Wiley & Sons, Ltd.
Reinecke Anion Derivatives and Homobinuclear Complexes as Tectons in Designing Heteropolymetallic Systems
Authors: Cucos Andrei , Avarvari Narcis , Andruh Marius , Journaux Yves , Müller Achim , Schmidtmann Marc 
Published: January 2006

AbstractTwo novel CrIII–NiII heteropolynuclear complexes have been obtained through a self‐assembly process involving abinuclear NiII complex with a macrocyclic Robson ligand and Reinecke‐type anions (trans‐[Cr(NCS)4(NH3)2]–, trans‐[Cr(NCS)4(4,4′‐bipy)2]–): [Ni2(H2O)2(fsal‐33){Cr(NCS)4(NH3)2}]·2H2O (1) and 1∞[Ni2(H2O)2(fsal‐33){Cr(NCS)4(4,4′‐bipy)2}]n·n[Cr(NCS)4(4,4′‐bipy)2] (2). The compartmental ligand results from the condensation of 2,6‐diformyl‐4‐methyl‐phenol with 1,3‐propanediamine. The crystal structure of 1 consists of neutral tetranuclear [CrNiNiCr] species, where each nickel ion is coordinated in one apical position by a Reinecke anion, and in the other one by an aqua ligand. The distances between the metallic centres in 1 are: Ni···Cr = 6.048 and Ni···Ni = 3.133 Å. Compound 2 contains infinite cationic chains constructed from binuclear [Ni–Ni] nodes, connected through trans‐[Cr(4,4′‐bipy)2(NCS)4] spacers, and uncoordinated trans‐[Cr(NCS)4(4,4′‐bipy)2]– ions. The CrIII and NiII ions are connected through 4,4′‐bipyridine ligands arising from the Reinecke‐type anion. The distance between the nickel and chromium ions within the chain is 11.252 Å. The magnetic properties of 1 have been investigated. Both Ni–Ni and Cr–Ni exchange interactions were found to be antiferromagnetic: JNiNi = –51.3 cm–1; JNiCr = –22.7 cm–1. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)