bluuebunny/crossref_metadata_2025_split huggingface dataset:
Invivo generated autologous plasmin enzyme assisted vitrectomy, partial circumferential-oral retinotomy, silicone oil injection in patients with chronic retinal detachment without posterior vitreous detachment
Authors: Aras Cengiz , Senturk Fevzi , Erdur Sevil Karaman , Dogramaci Mahmut , Kocabora Mehmet Selim , Demircan Ali , Budak Yunus Emre 
Published: April 2024

Abstract
Purpose
To report the results of invivo generated autologous plasmin enzyme(IVAP) assisted vitrectomy, partial circumferential-oral retinotomy and silicone oil injection for surgical treatment of patients with chronic retinal detachment without posterior vitreous detachment(PVD).

Methods
Study was performed in retrospective, comparative manner. A total of 16 consecutive eyes with chronic retinal detachment who had intravitreal injection of 50 µgr of t-PA and 0.1 ml of autologous whole blood, 3 days before surgery, underwent lens extraction with phacoemulsification, IVAP assisted vitrectomy, partial circumferential-oral retinotomy, and silicone oil injection(Study Group) were compared to a similar group of 15 eyes who had undergone vitrectomy, with or without lens extraction and silicone oil injection(Control Group) for the treatment of chronic retinal detachment. Primary outcome measures were initial retinal reattachment and number of operations at postoperative 6 months.

Results
Mean age of 16 patients of whom 7 were female, was 39.31 ± 17.76 years in study group and 15 patients of whom 4 were female, was 35.40 ± 11.92 years (p = 0.607). Mean follow-up time was 10.68 ± 7.15 months in study group and 29.13 ± 18.83 months in control group (p = 0.001). Initial retinal reattachment was achieved in 87.50% (14 out of 16 patients) in the study group, whereas it was 46.66% (7 out of 15 patients) in the control group (p = 0.017). The mean number of operations for reattachment in the study group was 1.12 ± 0.34, whereas it was 1.46 ± 0.51 in the control group (p = 0.039) at postoperative 6 months While the preoperative LogMAR visual acuity was 1.25 ± 0.64, it was 0.53 ± 0.37 at postoperative 6 months in study group (p = 0.001). Conversely, in the control group, the preoperative LogMAR visual acuity was 1.22 ± 0.33, it was 1.20 ± 0.89 at postoperative 6 months (p = 0.780). At postoperative 6 months,, epiretinal membrane developed in 2 eyes of the study group, 1 eye in the control group, and phthisis bulbi occurred in 1 eye of control group.

Conclusion
IVAP assisted vitrectomy, partial circumferential-oral retinotomy and silicone oil injection is effective and safe for the surgical treatment of chronic retinal detachment without PVD.
A study of non-uniform imperfect contact in shear wave propagation in a magneto-electro-elastic laminated periodic structure
Authors: Chaki Mriganka Shekhar , Bravo-Castillero Julián 
Published: April 2024

AbstractThe present study deals with shear wave propagation in a fully coupled Magneto-Electro-Elastic (MEE) multi-laminated periodic structure having non-uniform and imperfect interfaces. As a solution methodology, we applied a more general low-frequency dynamic asymptotic homogenization technique where the solution will be single-frequency dependent and the obtained results generalize those published in Chaki and Bravo-Castillero (Compos Struct 322:117410, 2023b) where the perfect contact case was studied. Effective homogenized dispersive equations of motion in second- and fourth-order approximations, also known as “Good” Boussinesq equations in elastic case, are derived. Local problems, closed-form expression of dispersion equations in second and fourth-order approximations and closed-form solutions of first and second local problems in second-order approximation for tri-laminated MEE periodic structure have been obtained and also validated for elastic laminates with imperfect contact case and MEE laminates with perfect contact case. The effect of non-uniform and imperfect contact, angle of incidence, unit cell size, volume fraction and ME-coupling on the wave propagation is illustrated through dispersion graphs. The effect of non-uniform and imperfect contact on dispersion curve serves as the highlight of the present work.
Imaging for local recurrence of breast cancer
Authors: Schlaiss T. , Bott L. , Herbert S.-L. , Bartmann C. , Kiesel M. , Salmen J. , Sauer S. T. , Christner S. A. , Petritsch B. , Grunz J.-P. , Woeckel A. , Löb S. , Diessner J. 
Published: April 2024

Abstract
Purpose
Isolated locoregional recurrence of breast cancer (ILRR) and contralateral breast cancer (CBC) affect up to 20% of all breast cancer (BC) patients in the first 20 years after primary diagnosis. Treatment options comprise surgical interventions and further systemic therapies depending on the histological subtype. Patients with hereditary breast or ovarian cancer (HBOC) undergo MRI, mammography, and ultrasound in the aftercare of BC, while non-HBOC (nHBOC) patients do not regularly receive MRI. Since early detection is crucial for morbidity and mortality, the evaluation and constant improvement of imaging methods of the breast is necessary.

Methods
We retrospectively analyzed the data of 1499 former BC patients that received imaging of the breast at a tertiary-care university hospital between 2015 and 2020. The analysis comprised various patient characteristics, such as breast density, age, tumor size and subtype, and their influence on BC detection rates by the different imaging methods.

Results
Within the patient sample, 176 individuals (11.7% of former BC patients) were diagnosed with either ILRR or CBC. CBC was observed in 32.4% of patients, while both ILRR and secondary breast cancer occurred in 20.5% and 23.9% of all patients. Sensitivity of MRI, mammography, and ultrasound for recurrent malignancy was 97.9%, 66.3%, and 67.8%, respectively. ILRR and CBC detection rates were similar for patients with and without HBOC history. Lower breast density and larger tumor size increased the detection rates of all imaging modalities.

Conclusion
In breast cancer survivors, MRI might improve the early detection of ILRR and CBC in both HBOC and nHBOC patients.
Transient computational homogenisation of one-dimensional periodic microstructures
Authors: Yağmuroğlu İrem , Ozdemir Zuhal , Askes Harm 
Published: April 2024

AbstractThis paper presents a methodology where a macroscopic linear material response incorporates microscopic variations, such as transient interactions and micro-inertia effects. This is achieved by implementing the temporal coupling between macro and microstructures, along with the spatial coupling, within a dynamic computational homogenisation framework. In the context of dynamic multiscale modelling, the temporal coupling method offers significant advantages by effectively reducing deviations emerging from micro-inertia effects and transient phenomena. The effectiveness of the developed procedure is validated by a comparison of the macroscopic results with the solutions of direct numerical simulation for a one-dimensional periodic laminate bar with different contrast levels. The homogenised results obtained using the developed procedure indicate that a better prediction of the macroscopic requires a larger Representative Volume Element (RVE) which improves the estimation of multiscale strain energy and a larger time window which improves the estimation of multiscale kinetic energy. The simultaneous increase in the RVE size and the time averaging window yields the best results in predicting the macroscopic response.
Relating preoperative MCS-12 to microdiscectomy outcomes
Authors: Heard Jeremy C. , Lee Yunsoo , Ezeonu Teeto , Lambrechts Mark J. , Narayanan Rajkishen , Yeung Caleb , Wright Justin , Paulik John , Purtill Caroline , Mangan John J. , Kurd Mark F. , Kaye Ian D. , Canseco Jose A. , Hilibrand Alan S. , Vaccaro Alexander R. , Schroeder Gregory D. , Kepler Christopher K. 
Published: April 2024

Abstract
Purpose
To determine the impact of poor mental health on patient-reported and surgical outcomes after microdiscectomy.

Methods
Patients ≥ 18 years who underwent a single-level lumbar microdiscectomy from 2014 to 2021 at a single academic institution were retrospectively identified. Patient-reported outcomes (PROMs) were collected at preoperative, three-month, and one-year postoperative time points. PROMs included the Oswestry Disability Index (ODI), Visual Analog Scale Back and Leg (VAS Back and VAS Leg, respectively), and the mental and physical component of the short form-12 survey (MCS and PCS). The minimum clinically important differences (MCID) were employed to compare scores for each PROM. Patients were categorized as having worse mental health or better mental health based on a MCS threshold of 50.

Results
Of 210 patients identified, 128 (61%) patients had a preoperative MCS score ≤ 50. There was no difference in 90-day surgical readmissions or spine reoperations within one year. At 3- and 12-month time points, both groups demonstrated improvements in all PROMs (p < 0.05). At three months postoperatively, patients with worse mental health had significantly lower PCS (42.1 vs. 46.4, p = 0.004) and higher ODI (20.5 vs. 13.3, p = 0.006) scores. Lower mental health scores were associated with lower 12-month PCS scores (43.3 vs. 48.8, p < 0.001), but greater improvements in 12-month ODI (− 28.36 vs.  − 18.55, p = 0.040).

Conclusion
While worse preoperative mental health was associated with lower baseline and postoperative PROMs, patients in both groups experienced similar improvements in PROMs. Rates of surgical readmissions and reoperations were similar among patients with varying preoperative mental health status.
GALNT2 expression is associated with glucose control and serum metabolites in patients with type 2 diabetes
Authors: Trischitta Vincenzo , Antonucci Alessandra , Adamski Jerzy , Prehn Cornelia , Menzaghi Claudia , Marucci Antonella , Di Paola Rosa 
Published: April 2024

Abstract
Aims
Aim of this study was to investigate in type 2 diabetes whether expression level of GALNT2, a positive modulator of insulin sensitivity, is associated with a metabolic signature.

Methods
Five different metabolite families, including acylcarnitines, aminoacids, biogenic amines, phospholipids and sphingolipids were investigated in fasting serum of 70 patients with type 2 diabetes, by targeted metabolomics. GALNT2 expression levels were measured in peripheral white blood cells by RT-PCR. The association between GALNT2 expression and serum metabolites was assessed using false discovery rate followed by stepwise selection and, finally, multivariate model including several clinical parameters as confounders. The association between GALNT2 expression and the same clinical parameters was also investigated.

Results
GALNT2 expression was independently correlated with HbA1c levels (P value = 0.0052), a finding that is the likely consequence of the role of GALNT2 on insulin sensitivity. GALNT2 expression was also independently associated with serum levels of the aminoacid glycine (P value = 0.014) and two biogenic amines phenylethylamine (P value = 0.0065) and taurine (P value = 0.0011). The association of GALNT2 expression with HbA1c was not mediated by these three metabolites.

Conclusions
Our data indicate that in type 2 diabetes the expression of GALNT2 is associated with several serum metabolites. This association needs to be further investigated to understand in depth its role in mediating the effect of GALNT2 on insulin sensitivity, glucose control and other clinical features in people with diabetes.
The effect of high-intensity laser therapy on pain and lower extremity function in patellofemoral pain syndrome: a single-blind randomized controlled trial
Authors: Ozlu Ozge , Atilgan Esra 
Published: April 2024

Abstract
Patellofemoral pain syndrome (PFPS) is a set of symptoms that negatively affect the daily life activities of the individual, leading to functional disability and significant loss of labor, especially in young adults. PFPS is usually due to weakness of the vastus medialis obliquus (VMO) resulting in abnormal patellar tracking and pain. Our study aims to compare the efficacy of high-intensity laser therapy (HILT) on pain and lower extremity function in the treatment of PFPS with different electrophysical agents (EPAs). The study was designed as a single-blind randomized controlled trial. Forty-five people with PFPS (aged 25–45 years) were included in the study. The patients were randomly divided into three groups and a total of ten sessions of treatment were administered to all three groups for 2 weeks, 5 days a week. High-intensity laser (HILT) and exercise program were applied to group 1. Ultrasound (US), transcutaneous electrical nerve stimulation (TENS), and exercise program were applied to group 2. In group 3, US, interferential current (IFC), and exercise program were applied. Both groups underwent three evaluations: pre-treatment, post-treatment, and 12 weeks after treatment. Outcome measures included the visual analog scale for pain severity (VAS), knee flexion range of motion (FROM), Q angle, pain threshold, muscle strength of quadriceps and hamstring, Kujala patellofemoral scoring, lower extremity functional scale (LEFS), and Timed Up and Go Test (TUG). The ANOVA was used for comparing the data of the groups, and two-way repeated measure ANOVA was used to compare at the pre-post and post-intervention 3rd month. The LSD and Bonferroni post hoc tests were also used to identify the between-group differences. Groups 2 and 3 were statistically effective in pain and functionality (p < 0.05). Group 1 was found to be statistically more effective than other groups in reducing pain (95% confidence interval (CI), 0.000/0.000; p = 0.000), increasing knee flexion angle (95% CI, 127.524/135.809; p = 0.000), and increasing lower extremity function (95% CI, 75.970/79.362; p = 0.000). This study indicated that high-intensity laser therapy was found to be a more effective method in the treatment of patellofemoral pain syndrome after 3 months of follow-up compared to US-TENS combination and US-interferential current combination treatments. Also, HILT can be used as an effective method in combination with an appropriate exercise program including vastus medialis strengthening to reduce pain and increase functionality in the patients with PFPS.
Adding salt to food at table as an indicator of gastric cancer risk among adults: a prospective study
Authors: Kronsteiner-Gicevic Selma , Thompson Alysha S. , Gaggl Martina , Bell William , Cassidy Aedín , Kühn Tilman 
Published: April 2024

Abstract
Background
While dietary salt intake has been linked with gastric cancer risk in Asian studies, findings from Western populations are sparse and limited to case—control studies. Our aim was to evaluate the frequency of adding salt to food at table in relation to gastric cancer risk among UK adults.

Methods
We evaluated associations between the frequency of adding salt to food and the risk of gastric cancer in the UK Biobank (N = 471,144) using multivariable Cox regression. Frequency of adding salt to food was obtained from a touchscreen questionnaire completed at baseline (2006–2010). 24-h urinary sodium excretion was estimated using INTERSALT formulae. Cancer incidence was obtained by linkage to national cancer registries.

Results
During a median follow-up period of 10.9 years, 640 gastric cancer cases were recorded. In multivariable models, the gastric cancer risk among participants reporting adding salt to food at table “always” compared to those who responded “never/rarely” was HR = 1.41 (95% CI: 1.04, 1.90). There was a positive linear association between estimated 24-h urinary sodium levels and the frequency of adding salt to food (p-trend <0 .001). However, no significant association between estimated 24-h urinary sodium with gastric cancer was observed (HR = 1.19 (95% CI: 0.87, 1.61)).

Conclusions
“Always adding salt to food” at table was associated with a higher gastric cancer risk in a large sample of UK adults. High frequency of adding salt to food at table can potentially serve as a useful indicator of salt intake for surveillance purposes and a basis for devising easy-to-understand public health messages.
Japanese Planocerid Flatworms: Difference in Composition of Tetrodotoxin and Its Analogs and the Effects of Ingestion by Toxin-Bearing Fishes in the Ryukyu Islands, Japan
Authors: Ueda Hiroyuki , Ito Masaaki , Yonezawa Ryo , Hayashi Kentaro , Tomonou Taiga , Kashitani Maho , Oyama Hikaru , Shirai Kyoko , Suo Rei , Yoshitake Kazutoshi , Kinoshita Shigeharu , Asakawa Shuichi , Itoi Shiro 
Published: April 2024

AbstractTetrodotoxin (TTX), known as pufferfish toxin, is a potent neurotoxin blocking sodium channels in muscle and nerve tissues. TTX has been detected in various taxa other than pufferfish, including marine polyclad flatworms, suggesting that pufferfish toxin accumulates in fish bodies via food webs. The composition of TTX and its analogs in the flatworm Planocera multitentaculata was identical to those in wild grass puffer Takifugu alboplumbeus. Previously, Planocera sp. from Okinawa Island, Japan, were reported to possess high level of TTX, but no information was available on TTX analogs in this species. Here we identified TTX and analogs in the planocerid flatworm using high-resolution liquid chromatography–mass spectrometry, and compared the composition of TTX and analogs with those of another toxic and non-toxic planocerid species. We show that the composition of TTX and several analogs, such as 5,6,11-trideoxyTTX, dideoxyTTXs, deoxyTTXs, and 11-norTTX-6(S)-ol, of Planocera sp. was identical to those of toxic species, but not to its non-toxic counterpart. The difference in the toxin composition was reflected in the phylogenetic relationship based on the mitochondrial genome sequence. A toxification experiment using predatory fish and egg plates of P. multitentaculata demonstrated that the composition of TTX and analogs in wild T. alboplumbeus juveniles was reproduced in artificially toxified pufferfish. Additionally, feeding on the flatworm egg plates enhanced the signal intensities of all TTX compounds in Chelonodon patoca and that of deoxyTTXs in Yongeichthys criniger.
Trade in Prevost’s squirrels: legality, risk for introduction and disease transmission
Authors: Nijman Vincent , Abdullah Abdullah , Ardiansyah Ahmad , Campera Marco , Chavez Jessica , Dewi Tungga , Hankinson Emma , Hedger Katherine , Imron Mohammad Ali , Manson Sophie , Morcatty Thais Q. , Payuse I Nyoman Aji Duranegara , Rapone Brittany C. , Shepherd Chris R. , Siriwat Penthai , Svensson Magdalena S. , Nekaris K.A.I. 
Published: April 2024

AbstractSquirrels traded for pets or consumption have the potential to be vectors for zoonotic disease transmission and to establish themselves as invasive species. Callosciurus spp. (Greek for beautiful squirrel) are popular in the pet trade due to their medium size and many colour variants, though several feral populations have established themselves in various parts of the world and these wild-caught individuals can carry and spread infectious diseases. Here, we investigate the live trade in Prevost’s squirrels (C. prevosti) in Indonesia where they are naturally found on the islands of Sumatra, Bangka and Borneo. Between 2016 and 2024, we recorded 284 Prevost’s squirrels for sale, viz., 115 in the physical markets and 169 online. We detected the species for sale in Sumatra (13 individuals), Bangka (7) and Borneo (3), i.e. within their natural range, but also on Java (242) and Bali (4). The mean asking price per individual was US$63, and younger individuals commanded higher prices than older ones. Asking prices were not higher in cities further away from the species’ native range nor in cities with higher purchasing power. All individuals were wild-caught, and with a domestic quota of five individuals allowed to be traded as pets per year (45 over the study period) most of this trade is illegal under Indonesian law. This is distinctly different from trade in Prevost’s squirrels in for instance Europe or the USA where legally captive-bred individuals are offered for sale. In Indonesia the illegal trade happens in the open and despite the risk of the spread of zoonotic diseases wherever it is traded there appears to be little incentive on the side of the authorities to curb this trade. Their widespread availability on Java and Bali risks the accidental or deliberate introduction on these two islands. Better coordination is needed between the Indonesian authorities, online sales sites, pet traders and consumers to stop the sale of illegally obtained Prevost’s squirrels to limit the risk of them becoming invasive species or contributing to the spread of emerging infectious diseases.
The role of long-term preparatory factors in mass rock creep deforming slopes: insights from the Zagros Mts. belt (Iran)
Authors: Delchiaro Michele , Della Seta Marta , Martino Salvatore , Moumeni Mohammad , Nozaem Reza , Marmoni Gian Marco , Esposito Carlo 
Published: April 2024

AbstractThe long-term evolution of slopes affected by Mass Rock Creep deformations is controlled by both time-invariant predisposing factors, such as the geo-structural inheritance, and time-dependent preparatory conditions, including regional uplift and landscape evolution rates. However, the relationship among Deep-seated Gravitational Slope Deformations, drainage network evolution, and tectonics remains poorly defined. Here, we focused on an undocumented Deep-seated Gravitational Slope Deformation affecting an area of about 8 km2 in the SE tip termination of the Siah Kuh anticline in the Lorestan arc (Zagros Mts., Iran), upstream to the Mountain Front Fault. To assess the evolution processes which involved the slope up to the present, we integrated quantitative geomorphic analysis, optically stimulated luminescence dating of geomorphic markers, and SAR interferometry techniques. In detail, we semi-automatically extracted the river terrace treads to which we associated an elevation above the thalweg based on the Relative Elevation Model allowing the order definition. The plano-altimetric distribution of the treads and the OSL ages of two levels of strath terraces sampled in the field have been correlated along the river longitudinal profile, allowing the estimation of an uplift rate of 2.8 ± 0.2 mm year−1 and 0.42 ± 0.03 mm year−1, respectively upstream and downstream of the Mountain Front Fault. SAR interferometry was used to spot present-day shallow ground displacements associated with the ongoing slope deformation, by processing 279 satellite Sentinel-1 (A and B) radar images of the ascending and descending orbit spanning from 06 October 2014 to 31 March 2019. Different landslide mechanisms were distinguished across the fold axis, rototranslative to lateral spreading interpreted as two different evolutionary stages of the same process transposed spatially through the fold axis. Indeed, the rototranslative mechanism represents an advanced stage of the strain evolution while the lateral spreading is an earlier one. Finally, we infer that the variability in the spatial distribution of the slope deformation styles and patterns in the Lorestan arc is strictly related to the coupled evolution of the drainage system and tectonics. Involved volumes (from 0.6 up to 44 km3), local relief (from 400 up to 2000 m), incision rates (from 0.8 to 2.8 ± 0.2 mm year−1), and persistence time (from 104 to 105 years) represent the most important preparatory conditions and are predisposed by a moderately dipping downslope (from 8 to 25°) sedimentary sequence characterised by units with significantly different rheological behaviour.