bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Mortality, Cardiovascular, and Renal Diseases in Women's Lives Following Hypertensive Disorders of Pregnancy: The Prospective Nationwide Study CONCEPTION
Authors: Lailler Grégory , Grave Clémence , Gabet Amélie , Joly Pierre , Regnault Nolwenn , Deneux‐Tharaux Catherine , Tstsaris Vassilis , Plu‐Bureau Geneviève , Kretz Sandrine , Blacher Jacques , Olie Valérie 
Published: April 2024

Background
We aimed to evaluate the impact of hypertensive disorders of pregnancy occurrence, recurrence, onset time, and severity on mortality and on a wide range of cardiovascular outcomes in France.

Methods and Results

CONCEPTION (Cohort of Cardiovascular Diseases in Pregnancy) is a French nationwide prospective cohort using data from the National Health Data System. We included all women in CONCEPTION with no history of a cardiovascular event who delivered in France for the first time between 2010 and 2018 (N=2 819 655). Hypertensive disorders of pregnancy and cardiovascular outcomes during the study follow‐up were identified using algorithms combining
International Classification of Diseases, Tenth Revision
(
ICD‐10
) coded diagnoses during hospitalization and purchases of medication between 2010 and 2021. We fitted Cox models with time‐varying exposure to assess the associations of hypertensive disorders of pregnancy with mortality and cardiovascular events. Women with gestational hypertension had a 1.25‐ to 2‐fold higher risk of stroke, acute coronary syndrome, peripheral arterial disease, pulmonary embolism, and chronic kidney disease, and a 2‐ to 4‐fold higher risk of rhythm and conduction disorder and heart failure. Women with preeclampsia had a 1.35‐ to 2‐fold higher risk of rhythm or conduction disorder and pulmonary embolism during follow‐up; a 2‐ to 4‐fold higher risk of stroke, acute coronary syndrome, and peripheral arterial disease; and a 7‐ to 9‐fold higher risk of heart failure and chronic kidney disease. They were 1.8 times more likely to die and 4.4 times more likely to die of cardiovascular causes.

Conclusions
Hypertensive disorders of pregnancy drastically increase the risk of mortality, cardiovascular, and renal events early after pregnancy. Recurrent, severe, and early‐onset preeclampsia further increases this risk.
Enantiomer‐Specific Cardiovascular Effects of the Ketone Body 3‐Hydroxybutyrate
Authors: Gopalasingam Nigopan , Moeslund Niels , Christensen Kristian Hylleberg , Berg‐Hansen Kristoffer , Seefeldt Jacob , Homilius Casper , Nielsen Erik Nguyen , Dollerup Mie Ringgaard , Alstrup Olsen Aage K. , Johannsen Mogens , Boedtkjer Ebbe , Møller Niels , Eiskjær Hans , Gormsen Lars Christian , Nielsen Roni , Wiggers Henrik 
Published: April 2024

Background
The ketone body 3‐hydroxybutyrate (3‐OHB) increases cardiac output (CO) by 35% to 40% in healthy people and people with heart failure. The mechanisms underlying the effects of 3‐OHB on myocardial contractility and loading conditions as well as the cardiovascular effects of its enantiomeric forms, D‐3‐OHB and L‐3‐OHB, remain undetermined.

Methods and Results

Three groups of 8 pigs each underwent a randomized, crossover study. The groups received 3‐hour infusions of either D/L‐3‐OHB (racemic mixture), 100% L‐3‐OHB, 100% D‐3‐OHB, versus an isovolumic control. The animals were monitored with pulmonary artery catheter, left ventricle pressure‐volume catheter, and arterial and coronary sinus blood samples. Myocardial biopsies were evaluated with high‐resolution respirometry, coronary arteries with isometric myography, and myocardial kinetics with D‐[
11
C]3‐OHB and L‐[
11
C]3‐OHB positron emission tomography. All three 3‐OHB infusions increased 3‐OHB levels (
P
<0.001). D/L‐3‐OHB and L‐3‐OHB increased CO by 2.7 L/min (
P
<0.003). D‐3‐OHB increased CO nonsignificantly (
P
=0.2). Circulating 3‐OHB levels correlated with CO for both enantiomers (
P
<0.001). The CO increase was mediated through arterial elastance (afterload) reduction, whereas contractility and preload were unchanged. Ex vivo, D‐ and L‐3‐OHB dilated coronary arteries equally. The mitochondrial respiratory capacity remained unaffected. The myocardial 3‐OHB extraction increased only during the D‐ and D/L‐3‐OHB infusions. D‐[
11
C]3‐OHB showed rapid cardiac uptake and metabolism, whereas L‐[
11
C]3‐OHB demonstrated much slower pharmacokinetics.

Conclusions
3‐OHB increased CO by reducing afterload. L‐3‐OHB exerted a stronger hemodynamic response than D‐3‐OHB due to higher circulating 3‐OHB levels. There was a dissocitation between the myocardial metabolism and hemodynamic effects of the enantiomers, highlighting L‐3‐OHB as a potent cardiovascular agent with strong hemodynamic effects.
Population Trends of New Prescriptions for Antihyperglycemics and Antihypertensives Between 2014 and 2022
Authors: Yu Amy Y. X. , Austin Peter C. , Jackevicius Cynthia A. , Chu Anna , Holodinsky Jessalyn K. , Hill Michael D. , Kamal Noreen , Kumar Mukesh , Lee Douglas S. , Vyas Manav V. , Joundi Raed A. , Khan Nadia A. , Kapral Moira K. , McNaughton Candace D. 
Published: April 2024

Background
In the wake of pandemic‐related health decline and health care disruptions, there are concerns that previous gains for cardiovascular risk factors may have stalled or reversed. Population‐level excess burden of drug‐treated diabetes and hypertension during the pandemic compared with baseline is not well characterized. We evaluated the change in incident prescription claims for antihyperglycemics and antihypertensives before versus during the pandemic.

Methods and Results
In this retrospective, serial, cross‐sectional, population‐based study, we used interrupted time series analyses to examine changes in the age‐ and sex‐standardized monthly rate of incident prescriptions for antihyperglycemics and antihypertensives in patients aged ≥66 years in Ontario, Canada, before the pandemic (April 2014 to March 2020) compared with during the pandemic (July 2020 to November 2022). Incident claim was defined as the first prescription filled for any medication in these classes. The characteristics of patients with incident prescriptions of antihyperglycemics (n=151 888) or antihypertensives (n=368 123) before the pandemic were comparable with their pandemic counterparts (antihyperglycemics, n=97 015; antihypertensives, n=146 524). Before the pandemic, monthly rates of incident prescriptions were decreasing (−0.03 per 10 000 individuals [95% CI, −0.04 to −0.01] for antihyperglycemics; −0.14 [95% CI, −0.18 to −0.10] for antihypertensives). After July 2020, monthly rates increased (postinterruption trend 0.31 per 10 000 individuals [95% CI, 0.28–0.34] for antihyperglycemics; 0.19 [95% CI, 0.14–0.23] for antihypertensives).

Conclusions
Population‐level increases in new antihyperglycemic and antihypertensive prescriptions during the pandemic reversed prepandemic declines and were sustained for >2 years. Our findings are concerning for current and future cardiovascular health.
The Development of Jazz in China and Its Intercultural Influence on Chinese Pop Music, from the 20th Century to the 21st Century
Authors: Bei Meiqianyi , Jian Li 
Published: April 2024

Abstract
What is the intercultural significance of jazz for the development of Chinese pop music? The main content of this dissertation is to study and discuss the period when jazz music entered China and how it affects the development of past and present Chinese pop music. In today’s society, intercultural research is ubiquitous. Since the birth of civilization, people from different disciplines and artistic fields have been trying to build cultural bridges.1 China has a long history of culture and music development. With the changes of the times, China’s music civilization has been continuously developed and changed with the replacement of various dynasties in the past. In addition, Confucius’s Confucianism has influenced the development of Chinese music and music education. The history of jazz music is not very long, but it has become an indispensable element of today’s social music culture. Perhaps it is because jazz has rich musical style features, such as improvisation and unique jazz scales. In addition, the musical content of its expression is democratic and free. The musical form of Jazz music originated in the United States in the late 19th and early 20th centuries, it is a combination of African black culture and European white culture. It is a kind of “hybrid” music form that affects the development of Chinese music with deep-rooted civilization, especially some Chinese pop music. The dissertation will study how jazz integrates Chinese music to produce Chinese pop music, as well as the intercultural influence of jazz, and how Jazz affects the pop singers of Chinese pop music.
Preoperative Nil Per Os Duration Predicts Mortality and Ambulation Following Below-Knee Amputation
Authors: Chao Natalie T. , Karwoski Allison S. , Pitsenbarger Luke T. , Som Maria N. , Dunlap Eleanor , Nagarsheth Khanjan H. 
Published: April 2024

Background Routine use of nil per os (NPO) prior to procedures has been associated with dehydration and malnutrition leading to patient discomfort. We aim to examine how duration of NPO status affects postoperative outcomes in patients undergoing elective below-knee amputation (BKA). Methods We performed a retrospective chart review of 92 patients who underwent elective BKA between 2014-2022 for noninfectious indications. We performed statistical analysis using Chi-square tests, t-tests, and linear/logistic regression with odds ratio using P < .05 as our significance level. Results The mean age was 48.0 ± 16.7 years, and there were 64 (70%) male patients and 41 (45%) Black patients. Mean NPO duration was 12.9 ± 4.7 hours. Patients with longer NPO duration were associated with increased rates of postoperative stroke ( P = .03). Patients with shorter NPO duration had significantly lower mean BUN on postoperative day (POD) 1 (14.5, P < .001) and POD 3 (14.1, P < .001) compared to preoperative mean BUN (16.8), however this normalized by POD 7 (19.2, P = .26). There were no changes in postoperative renal function based on baseline kidney disease status or associated with longer NPO duration. Shorter NPO duration was a predictor of increased likelihood of 1-year follow-up (OR: 2.9 [1.24-6.79], P = .01), independent ambulation (OR: 2.7 [1.03-7.34], P = .04), and decreased mortality (OR: .11 [.013-.91], P = .04). Conclusion While NPO duration does not appear to result in postoperative renal dysfunction, prolonged NPO duration predicts worse rates of follow-up, ambulation, and survival and is associated with increased stroke rates.
Prevalence of Household Food Security and Health-related Quality of Life: Special Consideration on the Expectant Mothers in Punjab
Authors: Arora Sugandh , Nabi Tawheed , Oberoi Sumit , Awasthi Vedica 
Published: April 2024

Household food security (HFS) affects the quality and adequacy of nutrition and can significantly impact an individual’s health. The study aims to examine the association between HFS and maternal quality of life in Punjab. The cross-sectional study was conducted in the northern Indian state of Punjab from January to March 2021 on 384 expectant mothers. The urban health facilities were chosen using the random cluster selection approach from geographical locations in Punjab, India. A well-structured questionnaire was adapted from HFS and health-related quality of life (HR-QoL) that was used to collect the data. Descriptive statistics were used to investigate the socioeconomic status and food security. HFS and HR-QOL relationship was studied using multilinear regression. The results revealed that 43.9% of expectant women experienced food insecurity. Mean (±SD) scores for the domains of ‘social performance’ (84.4 ± 16.6) and ‘role limitation due to physical reasons’ (64.5 ± 35.5) were the highest in pregnant women. Quality of life scores for expectant mothers with food insecurity were the lowest. Due to physical reasons, role constraint scored the weakest for pregnant women with food insecurity (64.3 ± 45.5, 69.1 ± 43.2 and 49.3 ± 57.2, respectively, for mild, moderate and severe food insecurity). High-risk pregnant women screened for HFS in their primary prenatal care can increase their diet quality and quantity. Additionally, there is a need for multi-level actions such as policy development, resource allocation and proper amenities to ensure expectant mothers have access to nutritious food. JEL Codes: D1, I0, I30, I31
Effects of online coping skills training on stress, anxiety and social problem solving in young people: A randomised controlled study
Authors: Özkan Esma , Altuntaş Onur 
Published: April 2024

Background: Although most young people successfully manage the transition from childhood to adulthood, the speed and magnitude of these changes can cause stress that can exceed the coping abilities of many young people. Previous studies have suggested that adolescence is a vulnerable period for the development of psychiatric disorders; therefore, an adequate coping repertoire must be developed. Aims: Our aims were to develop and implement a coping skills training for young people and to evaluate the results of the training. Therefore, the components of the coping skills training programs in the existing literature were used. Methods: Young people from Turkey participated in this cluster randomised controlled trial ( n = 89; mean age, 20.06 ± 1.44 years). Ten sessions of the coping skills training were applied in the study group (SG; n = 33), and one session was applied in the control group (CG; n = 56). To assess the effects of the coping skills training, all participants completed several psychological questionnaires (for stress, anxiety, coping and social problem-solving evaluations) at the beginning and end of the training. We performed an analysis of covariance (ANCOVA). In cases where ANCOVA assumptions could not be met, the efficacy of the intervention was determined using the mixed design/split-plot analysis of variance. Results: Compared with the CG, the SG had significantly reduced stress and anxiety levels and increased adaptive coping skills. Social problem-solving skills remained relatively similar between the groups. Conclusion: Complete and correct implementation of coping skills training among the youth may contribute positively to the development of adaptive coping skills by reducing their stress and anxiety levels. This online coping skills training program allowed young people to directly experience their response to stress and offered opportunities to try and develop different coping strategies. Coping skills should be considered for successful stress and anxiety management in everyday life.
Wastewater Surveillance of US Coast Guard Installations and Seagoing Military Vessels to Mitigate the Risk of COVID-19 Outbreaks, March 2021–August 2022
Authors: Hall Gregory J. , Page Eric J. , Rhee Min , Hay Clara , Krause Amelia , Langenbacher Emma , Ruth Allison , Grenier Steve , Duran Alexander P. , Kamara Ibrahim , Iskander John K. , Alsayyid Fahad , Thomas Dana L. , Bock Edward , Porta Nicholas , Pharo Jessica , Osterink Beth A. , Zelmanowitz Sharon , Fleischmann Corinna M. , Liyanage Dilhara , Gray Joshua P. 
Published: April 2024

Objectives: Military training centers and seagoing vessels are often environments at high risk for the spread of COVID-19 and other contagious diseases, because military trainees and personnel arrive after traveling from many parts of the country and live in congregate settings. We examined whether levels of SARS-CoV-2 genetic material in wastewater correlated with SARS-CoV-2 infections among military personnel living in communal barracks and vessels at US Coast Guard training centers in the United States. Methods: The Coast Guard developed and established 3 laboratories with wastewater testing capability at Coast Guard training centers from March 2021 through August 2022. We analyzed wastewater from barracks housing trainees and from 4 Coast Guard vessels for the presence of SARS-CoV-2 genes N and E and quantified the results relative to levels of a fecal indicator virus, pepper mild mottle virus. We compared quantified data with the timing of medically diagnosed COVID-19 infection among (1) military personnel who had presented with symptoms or had been discovered through contact tracing and had medical tests and (2) military personnel who had been discovered through routine surveillance by positive SARS-CoV-2 antigen or polymerase chain reaction test results. Results: Levels of viral genes in wastewater at Coast Guard locations were best correlated with diagnosed COVID-19 cases when wastewater testing was performed twice weekly with passive samplers deployed for the entire week; such testing detected ≥1 COVID-19 case 69.8% of the time and ≥3 cases 88.3% of the time. Wastewater assessment in vessels did not continue because of logistical constraints. Conclusion: Wastewater testing is an effective tool for measuring the presence and patterns of SARS-CoV-2 infections among military populations. Success with wastewater testing for SARS-CoV-2 infections suggests that other diseases may be assessed with similar approaches.
Association between allostatic load and depression in patients with sleep disorders: Evidence from the National Health and Nutrition Examination Survey (NHANES)
Authors: Li Yiru , Yan Junli , Li Yuhong 
Published: April 2024

Objective Allostatic load (AL) is an indicator of the cumulative wear and tear on the body's physiological systems that can predict onset of a range of health problems. However, the relationship between AL and depression in patients with sleep disorders is unclear. This study explored the association between AL and depression in patients with sleep disorders. Methods Using data from the 2015-2016 National Health and Nutrition Examination Survey, a total of 4618 adults aged 18 years and older in the United States were included in this cross-sectional analysis. AL was calculated using nine biological markers, with a score of ≥3 indicating a high level. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9), with a score of ≥10 indicating risk for depression. Logistic regression models were employed to analyze the relationship between AL and depression. Results Among the 1309 participants diagnosed with sleep disorders, 212 (16.2%) were identified as being at risk for depression on the PHQ-9. A total of 55.2% (n = 117) of depressed persons had high AL levels. In the unadjusted model, AL levels were associated with depression in those with sleep disorders ( OR=1.53, 95% CI = 1.14-2.05, p < 0.01). This relationship remained significant in the adjusted model ( OR=1.52, 95% CI=1.11-2.10, p < 0.05), after controlling for potential confounders. Conclusion High AL levels in patients with sleep disorders were positively associated with depression, indicating that elevated AL may increase the risk of depression in this population, or alternatively, depression may increase the risk of AL.
Predictors for surgical treatment in male patients with non-neurogenic lower urinary tract symptoms (LUTS)
Authors: Hopland-Nechita Florin V , Andersen John R , Beisland Christian 
Published: April 2024

Objective: This study aimed to identify clinical and biochemical predictors for future surgical intervention in male LUTS patients. Materials and Methods: In a prospective cohort study, parameters as International Prostate Symptom Score (IPSS) and IPSS “bother question” (IPSS-BQ), prostate volume (PV), maximal urine flow (Qmax), Prostate specific antigen (PSA), post-voidal residual urine (PVR) were assessed alongside comorbidities quantified using Charlson Comorbidity Index without age adjustment and American Society of Anesthesiology (ASA) score. For the statistical analysis, patients were categorized based on subsequent treatment approaches: Group 1: underwent surgery during follow-up; Group 2: received medical or no treatment. T-test was used to test differences between the groups. Logistic regression models were used to identify independent predictors of the need for future surgery. Following this analysis, we calculated the probability of requiring surgical intervention, with this likelihood being determined based on the accumulation of identified predictive factors. Results: Of 63 patients, 22 underwent surgery over a median follow-up of 42 months. Significant baseline differences were observed in IPSS ( p = 0.003), International Prostatic Symptom Score-Voiding subscore (IPSS-VS) ( p = 0.002), IPSS-BQ ( p = 0.001), Qmax ( p = 0.007), and PVR ( p = 0.02) between the groups. Higher IPSS-BQ, IPSS-VS, and lower Qmax are emerging as independent surgical treatment predictors in logistic regression analyses. Conclusion: The study identified IPSS-VS, IPSS-BQ, and Qmax as baseline predictors of future surgical intervention. A clear pattern of a gradual increase in the likelihood of requiring surgery was directly proportional to the cumulative number of these identified predictive factors.
Improving 1-Year Mortality Following Intensive Care Unit Admission in Adults with HIV: A 20-Year Observational Study
Authors: Kanitkar Tanmay , Bakewell Nicholas , Dissanayake Oshani , Symonds Maggie , Rimmer Stephanie , Adlakha Amit , Lipman Marc C. I. , Bhagani Sanjay , Agarwal Banwari , Sabin Caroline A. , Miller Robert F. 
Published: April 2024

Background Despite widespread use of combination antiretroviral therapy, people with HIV (PWH) continue to have an increased risk of admission to and mortality in the intensive care unit (ICU). Mortality risk after hospital discharge is not well described. Using retrospective data on adult PWH (≥18 years) admitted to ICU from 2000-2019 in an HIV-referral centre, we describe trends in 1-year mortality after ICU admission. Methods One-year mortality was calculated from index ICU admission to date of death; with follow-up right-censored at day 365 for people remaining alive at 1 year, or day 7 after ICU discharge if lost-to-follow-up after hospital discharge. Cox regression was used to describe the association with calendar year before and after adjustment for patient characteristics (age, sex, Acute Physiology and Chronic Health Evaluation II [APACHE II] score, CD4+ T-cell count, and recent HIV diagnosis) at ICU admission. Analyses were additionally restricted to those discharged alive from ICU using a left-truncated design, with further adjustment for respiratory failure at ICU admission in these analyses. Results Two hundred and twenty-one PWH were admitted to ICU (72% male, median [interquartile range] age 45 [38–53] years) of whom 108 died within 1-year (cumulative 1-year survival: 50%). Overall, the hazard of 1-year mortality was decreased by 10% per year (crude hazard ratio (HR): 0.90 (95% confidence interval: 0.87-0.93)); the association was reduced to 7% per year (adjusted HR: 0.93 (0.89-0.98)) after adjustment. Conclusions were similar among the subset of 136 patients discharged alive (unadjusted: 0.91 (0.84-0.98); adjusted 0.92 (0.84, 1.02)). Conclusions Between 2000 and 2019, 1-year mortality after ICU admission declined at this ICU. Our findings highlight the need for multi-centre studies and the importance of continued engagement in care after hospital discharge among PWH.