bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of PDGFA as a Neutrophil-related Biomarker Linked to the Advancement of Diabetic Retinopathy through Integrated Bioinformatics Analysis
Authors: Liang Anran , Feng Tingting , Gao Xiang , Zhao Bowen , Chen Song 
Published: March 2024

Background:
The dysregulation of the innate immune system plays a crucial role in the
development of Diabetic Retinopathy (DR). To gain an insight into the underlying mechanism of
DR, it is essential to identify specific biomarkers associated with immune cell infiltration.

Methods:
In this study, we retrieved the GSE94019 and GSE60436 datasets from the Gene Expression
Omnibus (GEO) database. By utilizing CIBERSORT, MCPcounter, and xCell algorithms,
we conducted a comprehensive analysis of the immune cell infiltration landscape in DR.
The limma package was employed to identify Differentially Expressed Necroptosis-related Genes
(DENRGs). Subsequently, enrichment analysis was performed to investigate the potential functions
of the DENRGs. To identify the core DENRGs, the CytoHubba plug-in in Cytoscape software was
utilized. The expression levels of these core DENRGs were verified in an independent dataset.

Results:
Our analysis identified 213 DENRGs, and among them, Platelet-derived Growth Factor
subunit A (PDGFA) was identified as a core DENRG. Notably, the expression of PDGFA was
found to be upregulated in DR, and this finding was further validated in the GSE102485 dataset.
Additionally, the results of GSVA and GSEA revealed that in the high PDGFA group, there was
activation of pathways related to inflammation and the immune system. Moreover, analysis of
immune infiltration demonstrated a significant association between PDGFA gene expression
and the infiltration levels of specific immune cells, including basophils, macrophages M1, macrophages,
neutrophils, monocytes, NK cells, and B cells.

Conclusion:
The involvement of neutrophils in the development and progression of DR is suggested.
PDGFA has emerged as a potential marker and is linked to the infiltration of immune
cells in DR. These findings shed new light on the underlying mechanisms of DR.
Emerging Role of Ionic Liquids in the Fabric Industry
Authors: Gazal Umaima 
Published: March 2024

Abstract:
Profitable interest in the pervasive packaging of ionic liquids has continued to increase
due to its several advantages and environmentally pleasant nature. Fabric enterprise is stated to
be the most important enterprise as a result of a rapid increase in the populace across the globe.
Certain ionic beverages can dissolve textile fibers. Therefore, ionic liquids are doubtlessly
appropriate for material production and recycling. The dyeing of fabric substances involves
numerous financial and ecological risks, resulting in an excessive intake of water, power, and
chemicals. Ionic liquids surpass through their extraordinarily low vapor pressure, which enables
them to deal with commonly used natural solvents. Moreover, ionic liquids display excessive
temperature-associated dielectric constants, consequently displaying top-notch solvent strength
for distinct fabric-associated substances, inclusive of silicones, keratin, and cellulose. This article
provides a brief review of the pertinent literature that focuses on historical patterns and practical
commercial applications of ionic liquids before moving on to current developments in ionic
liquids and the fabric industry.
A SYSTEMATIC REVIEW ON MALARIA DISEASE AND ITS TREATMENTS FOCUS ON ARTEMETHER DRUG
Authors: PHALAK SWAPNIL D. , BODKE VISHAL , BODKE VISHAL , PANDAV SATISH , RANAWARE MALOJI 
Published: March 2024

Malaria is one of the infectious illnesses of the highest scientific significance and importance to international health organizations. Plasmodium falciparum, the parasite responsible for a highly severe form of the disease in Africa, has traditionally received the most attention. However, in the last two decades, the Plasmodium vivax parasite, which is linked to a large number of cases in Latin America, the Middle East, South and Southeast Asia, the Horn of Africa, and Oceania, has sparked enormous interest, owing to published evidence that it can cause severe malaria, among other things. Malaria is a worldwide public health problem, with a saw 247 million cases recorded in 2021. African countries accounted for approximately 94% of all reported cases. So far, over 200 distinct varieties of protozoa have been discovered and identified, with at least 13 of them being pathogenic to humans. The malaria parasite's life cycle is a complex process involving a mosquito with the species Anopheles and a vertebrate host.
Artemether is a lipid-soluble artemisinin derivative. It is available in both oral and intramuscular forms. It is also available as a fixed-dose formulation with lumefantrine. Artemether-lumefantrine is one of the ACTs authorized by the WHO and is being used by the majority of countries transitioning from less effective medications to ACTs. However, the emergence of antimalarial medication resistance poses a significant challenge to malaria control. It works by killing the pathogenic organisms responsible for malaria. It is known as an antimalarial medication, and it is more effective than quinine therapies.
Peran Zakat dalam Mengatasi Stunting dan Gizi Buruk di Kabupaten Brebes
Authors: Abdul Haris  , Miftaakhul Amri  
Published: March 2024

Stunting adalah kondisi gagal tumbuh pada anak berusia di bawah lima tahun (balita) akibat kekurangan gizi kronis dan infeksi berulang terutama pada periode 1.000 Hari Pertama Kehidupan (1000 HPK), yaitu dari janin hingga anak berusia 23 bulan. Anak tergolong stunting menurut WHO apabila panjang atau tinggi badannya berada di bawah minus 2 standar deviasi panjang atau tinggi anak seumurnya. Sehingga periode 1.000 Hari Pertama Kehidupan (HPK) harus mendapatkan perhatian khusus karena menjadi penentu tingkat pertumbuhan fisik, kecerdasan dan produktivitas seseorang di masa depan. Peran zakat, infak dan sedekah bagi umat islam adalah keniscayaan dalam implentasi keimanan seorang muslim untuk membantu saudara saudara sesama muslim dalam Upaya mengentaskan kemiskinan dan menyejahterakan Masyarakat. Lembaga Negara yang bertugas mengumpulkan zakat, infak, sedekah ( ZIS ) BAZNAS, sebagai amil negara dan mendistribusikan kepada yang berhak, dan membantu program Pemerintah pengentasan kemiskinan, di kelola secara profesional, akuntabel, transparan, aman secara syari, aman regulasi dan aman NKRI. Mendayagunakan ZIS oleh Amil Baznas dan Pemerintah membantu mengatasi Stunting dan gizi buruk dengan meningkatkan Kesehatan balita, bentuk pendistribusian produktif dalam membantu program pemerintah mengatasi kemiskinan. Penelitian dengan metode kualitatif, akan membantu Amil dan Pemerintah mengambil kebijakan penguatan peran BAZNAS sebagai solutif peningkatan Kesehatan Balita dalam penurunan Stunting dan gizi buruk.
Plant-based diets in patients with chronic kidney disease
Authors: Wathanavasin Wannasit , Kittiskulnam Piyawan , Johansen Kirsten L. 
Published: March 2024

Abstract
Dietary protein restriction has been considered to be a nutritional-related strategy to reduce risk for end-stage kidney disease among patients with non-dialysis-dependent chronic kidney disease (CKD). However, there is insufficient evidence to recommend a particular type of protein to slow down the CKD progression. Recently, various plant-based diets could demonstrate some additional benefits such as a blood pressure-lowering effect, a reduction of metabolic acidosis as well as hyperphosphatemia, and gut-derived uremic toxins. Furthermore, the former concerns about the risk of undernutrition and hyperkalemia observed with plant-based diets may be inconsistent in real clinical practice. In this review, we summarize the current evidence of the proposed pleiotropic effects of plant-based diets and their associations with clinical outcomes among pre-dialysis CKD patients.
Management of ectopic pregnancy after in vitro fertilization/intracytoplasmic sperm injection and embryo transfer: a case series and mini-review
Authors: Zhang Yang , Zhai Yan , Qu Danni 
Published: March 2024

Abstract

Background
Ectopic pregnancy (EP), reflecting a fertilized ovum implanted outside the normal uterine cavity, represents a frequent cause of morbidity and possibly mortality in women of reproductive age.

Objective
To summarize the diagnosis and treatment of EP after in vitro fertilization/intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET).

Methods
The medical records of patients who were diagnosed with EP after embryo transfer from 2017 to 2019, in a tertiary hospital were reviewed.

Results
Of the 24 cases analyzed, 21 (87.5%) had fallopian tube involvement, while 2 (8.3%) and 1 (4.2%) had cornual and cervical pregnancies, respectively. Clinical manifestations included vaginal bleeding (58.3%) and lower abdominal pain (16.7%); 9 (42.9%) cases had no symptoms. One cornual pregnancy was misdiagnosed as acute appendicitis and later correctly diagnosed by laparoscopic exploration. There were 2 cases of multiple-site EP and 2 of heterotopic pregnancy, including one with an intrauterine pregnancy with double chorionic and four amniotic sacs and right tubal ampullary pregnancy. Five of the 21 cases with fallopian tube involvement received conservative treatment, while the remaining 16 underwent surgeries, including laparoscopic ipsilateral salpingostomy and ipsilateral salpingectomy.

Discussion
Ectopic pregnancy after embryo transfer, mainly involving the fallopian tube, is very complex and is with diverse manifestations. Even with the pregnancy sac observed in the uterus, the pelvic cavity should be scanned thoroughly after embryo transfer.
Early interceptive treatment of a skeletal open bite using a vertical holding appliance in combination with myofunctional therapy, and a smile-clenching-swallow exercise: a case report with a 3-year follow-up
Authors: Noh Hyung-Kyu , Kim Ho-Jin , Park Hyo-Sang 
Published: March 2024

Abstract
This case report aimed to describe the effectiveness of myofunctional therapy involving a vertical holding appliance and a smile–clenching–swallow exercise for vertical control, in a growing patient who presented with a high-angle facial pattern. A 10-year-old girl sought treatment for a skeletal open bite. Early interception aimed to reduce the divergent skeletal growth pattern. The patient was asked to perform a smile–clenching–swallow exercise by pushing the tongue dorsum against a palatal resin pad on a transpalatal arch. The action exerted an upward force on the maxillary first molars, which reinforced the effects of myofunctional therapy. This interaction between the tongue and resin pad resulted in positive feedback, and a constant intrusive force delivered to the molars and balanced co-operation from the orofacial musculature. The initial vertical skeletal discrepancy was successfully resolved within 3 months. The subsequent fixed appliance treatment was straightforward. After 3 years of follow-up, the treatment outcome was stable.
Risk Factors Associated with Severe Systemic Allergic Reaction after Wasp Sting in Subjects with a History of European Hornet Sting Allergy
Authors: Perčič Simona , Košnik Mitja , Zaletel Kragelj Lijana , Bojanić Lidija , Kukec Andreja 
Published: March 2024

Abstract

Aim
To make the treatment approach in patients suffering a European hornet sting allergy reaction more personalized, preparing them also for possible future risks.

Methods
In Slovenia an extended retrospective observational cohort epidemiological study about the natural history of Hymenoptera venom sensitivity is in progress. The study is based on data from the healthcare records of the University Clinic Golnik (UCG) and data collected by a questionnaire sent to patients from May 2019 to April 2021. For a pilot study, we selected patients who were referred to UCG because of an allergic reaction to European hornet sting and had been re-stung later by a wasp (n=68). The association between severe systemic allergic reactions (SSAR) after wasp sting and potential risk factors in subjects with a history of hornet sting allergy was assessed univariately using the likelihood ratio test.

Results
Among 68 European hornet allergic patients 27 reacted with an SSAR and 41 reacted with a mild SAR. Among 27 patients with SSAR, 4 reacted with an SSAR also to a subsequent wasp sting. Among 41 patients with a mild European hornet sting SAR nobody reacted with an SSAR to a subsequent wasp sting. The association between the severity of the wasp SAR reaction in European hornet allergic patients was statistically significant (p=0.022).

Conclusion
Our results suggest that patients with severe European hornet SAR should be considered for wasp venom immunotherapy or prophylactic prescription of epinephrine auto-injector as they are at risk for an SSAR also after wasp string.
Unmet Needs in the Process of Chemotherapy Provision in Pancreatic Cancer Patients from the Healthcare Provider Perspective: A Phenomenological Study in Greece
Authors: Ploukou Stella , Papakosta-Gaki Εleni , Panagopoulou Efharis , Benos Alexios , Smyrnakis Emmanoui 
Published: March 2024

Abstract

Introduction
Pancreatic cancer is the fourth leading cause of cancer death overall, with 1.5 years life expectancy and minimal therapeutic progress in the last decades. Despite the burden it causes, there is little research on the needs of this specific population. This study aimed to explore healthcare professionals’ views on providing care and patients’ unsatisfied needs.

Methods
This qualitative descriptive study was carried out at a cancer hospital in Northern Greece. A total of 12 participants (6 physicians and 6 nurses), treating patients with pancreatic cancer undergoing chemotherapy, were recruited through purposive sampling and underwent face-to-face semi-structured interviews. Data were analyzed through the thematic analysis method in NVivo12 software.

Results
The analysis highlighted two themes: “needs of patients with pancreatic cancer” consisted of 6 subthemes (“daily activities”, “symptoms management”, “psychological support”, “information needs”, “multidisciplinary care” and “end-of-life care”) and “needs of healthcare professionals” had 3 subthemes (“psychological support”, “education” and “organizational support”). Several symptoms are identified and affect the daily activities of these patients, and psychological support is important for the majority of them, even at the time of diagnosis. The participants express dissatisfaction with the absence of palliative care structures and services and stated that an interdisciplinary approach would improve the quality of care.

Conclusions
Healthcare professionals report a wide range of unsatisfied needs of patients with pancreatic cancer, with the majority expressing their concerns about the complete lack of patient support in the last stages of their lives.
Enhancing Well-Being: Menstrual Sanitation Practices Amongst Rural Adolescent Girls in Tamil Nadu, India
Authors: Bhutia Pema Choden , S. Gnana Sanga Mithra , S. Suriya 
Published: March 2024

Aim: A campaign to afford free sanitary pads to teen girls in countryside regions has been launched by the Tamil Nadu government in India. The menstrual well-being and sanitation follows of teens in a rural area of North Tamil Nadu, India are discussed in this paper, as well as their experiences utilising sanitary pads and discarded clothing.

Subject and Methods: 134 adolescent girls from four villages participated in a community-based study that lasted four months and used a pre- and post-design to collect qualitative and quantitative data. The awareness of menstruation and its practises, value of life, experience with and serenity with different clothes/pads, and symptoms of reproductive tract infections were all shielded in the questionnaires.

Results: At the baseline survey 90% of girls at the time were wearing worn-out clothing. Sixty-eight percent of teenage females who participated in the study stated pads remained their top optimal. None of them liked wearing worn-out clothing. The quality of life significantly increased after the insertion of pads (p 0.000). Self-reported signs of recurrent reproductive tract infections did not significantly decrease.

Conclusion: This study revealed that unhygienic behaviours, such as societal limitations on food and home chores, were extensively prevalent and that most adolescent females lacked the proper understanding regarding menstruation. This research underscores the need for menstrual hygiene education and awareness.
Law Enforcement Toward Illegal Limestone Mining in Gunungkidul Regency, Indonesia
Authors: Harjiyatni Francisca Romana , Hartanti  , Katu Chrismayanti Angelia Y. 
Published: March 2024

Purpose: This paper aims to analyze law enforcement toward cases of illegal limestone mining in Gunungkidul Regency and its obstacles.

Methods: This research uses a social-legal approach. Data were obtained from in-depth interviews with resource persons and community members. Apart from that, data is also obtained through observations. Researchers analyzed the data obtained qualitatively.

Result and Conclusion: The results show that law enforcement against illegal limestone mining cases is not the same in every case, some are criminally processed, and some are not. Cases of illegal limestone mining that are criminally processed are caused by strong pressure from the community because illegal limestone mining damages the environment. Two cases of illegal limestone mining were criminally processed and subject to criminal sanctions and fines. This difference in handling illegal limestone mining creates legal uncertainty and difficulties in controlling limestone miners to comply with permits. Several obstacles arise in law enforcement against illegal limestone mining, namely the lack of public awareness of the importance of legal protection for the environment and differences in society between community groups that prioritize environmental protection and community groups that prioritize economic interests.

Research Implications: This research is useful for creating law enforcement that has a deterrent effect on illegal limestone miners, so that people have the awareness to carry out limestone mining legally based on permission from authorized officials. Apart from that, it is also to create law enforcement that provides certainty, so that there are no different solutions to each case of illegal limestone mining.

Originality/value: Finding effective solutions to limestone mining cases, so as to increase community compliance in carrying out limestone mining in accordance with the provisions of statutory regulations.
Operations Outside the Scope of Value Added Tax: A Possible Analysis of the Portuguese Wine Sector
Authors: Soares Ricardo de Moraes e , Heliodoro Paula , Martins Vanda , Oliveira Carla 
Published: March 2024

Objective: The study aims to analyse and clarify the VAT framework in participation association contracts, distinguishing between contractual and tax obligations.

Method: It includes a case study and a detailed analysis of partnership contracts, case law, and tax doctrine. The data was interpreted in light of the relevant tax laws, distinguishing between contractual and tax obligations in order to determine the VAT framework.

Results and conclusions: The results show that the liabilities borne by the associate (Entity B) should be considered supplies of services subject to VAT. The contribution of the associate (Entity B) is not subject to tax. These distinctions allow for a correct application of tax law. The conclusions reveal the possible readings of the application of VAT.

Implications if the research: Research is important to ensure the correct application of tax law in partnership agreements. This analysis can help promote the correct application of VAT and more efficient financial management for both parties involved. It provides relevant insights for academia, society, and policymakers.

Originality/value: It is the result of detailed observation of the VAT framework in association in participation contracts, providing possible insights in order to avoid possible tax uncertainties and ensure the correct reading of the tax law in more complex commercial transactions.
Articulation Between Collective Skills Development and Social Innovation: An Analysis in Non-Profit Civil Society Organizations in the Jequitinhonha nd Mucuri Valleys, State of Minas Gerais, Brazil
Authors: Vieira Naldeir dos Santos , Higuchi Agnaldo Keiti , Da Silva Edimilson Eduardo , Souza Marcio Coutinho de , Costa Isadora Camilo 
Published: March 2024

Objective: This study aims to analyze the relationship between the development of collective skills and social innovation in Non-Profit Civil Society Organizations (CSOs) located in the Middle and Lower Jequitinhonha and the Mucuri Valley, Minas Gerais state, Brazil.

Theoretical Benchmark: Theoretical approaches to CSOs, social innovation and collective skills were carried out.

Method: To do so, the application of online survey and in-depth case studies in OSC of the said field was carried out. The data from the first stage were analyzed using descriptive statistics, exploratory factor analysis and multiple linear regression, and those from the qualitative stage were analyzed via content analysis.

Results and Conclusion: The results indicated that some of the CSOs studied carry out actions considered as socially innovative and that the collective competences related to cooperation are those that have a significant influence on social innovation. In addition, it was observed that the CSOs studied, by engaging in socially innovative actions, created spaces and conditions conducive to the development of collective skills, enabling social interactions, which are fundamental for cooperation, knowledge sharing and social learning of those involved. Thus, there is a dialectical relationship between the collective skills constructs and social innovation, the development of some of them may reflect in a virtuous cycle in which the practice impacts on collective capacity development and this development in the improvement of new practices, or vice versa.

Research Implications: The findings emphasize the need for university extension practices and interventions that facilitate cooperation practices, as well as the sharing of knowledge and commitment in the context of CSOs, which can contribute more effectively in the search for the development of socially innovative actions.

Originality/value: This study presents an original and valuable approach when analyzing the relationships between collective skills development and social innovations in CSOs, revealing significant insights on good practices in this field.