bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of clinical features with psychological status in primary fibromyalgia
Authors: Yunus Muhammad B. , Ahles Tim A. , Aldag Jean C. , Masi Alfonse T. 
Published: February 2007

AbstractClinical features and psychological status determined by the Minnesota Multiphasic Personality Inventory (MMPI) in 103 patients with primary fibromyalgia syndrome (PFS) were analyzed by univariate and multivariate techniques to determine if clinical features were related to psychological status or were intrinsic to PFS per se. The central features of PFS, e.g., number of pain sites, number of tender points, fatigue, and poor sleep, were independent of psychological status. However, discriminant analysis identified 4 variables—patient‐reported depression, anxiety, stress, and pain severity—which together predicted 3 MMPI subgroups with an accuracy of 55% (P < 0.001); the only musculoskeletal feature—pain severity—alone provided an accuracy of only 34% (P > 0.05). These data suggest a new concept, that the central features of fibromyalgia are independent of the psychological status and are more likely related to the PFS itself. However, pain severity may be influenced by psychological factors.
Restoration of the DNA binding activity of estrogen receptor in MRL‐lpr/lpr mice by a polyamine biosynthesis inhibitor
Authors: Thomas Thresia , Gunnia Uma B. , Seibold James R. , Thomas T. J. 
Published: February 2007

AbstractDiverse data link estrogen influences to both the frequency and severity of systemic lupus erythematosus in humans and to murine lupus. A fundamental mechanism of action of estrogen involves the interaction of the hormone with its receptor protein, which is then transformed into the DNA binding form. We measured the concentration of uterine estrogen receptor and its DNA binding in normal BALB/c mice, lupus‐prone MRL‐lpr/lpr mice, and MRL‐lpr/lpr mice that had been treated with 1% difluoromethylornithine (DFMO). Uterine estrogen receptor levels in 20‐week‐old mice from the 3 groups were not significantly different. In contrast, DNA binding activity was significantly higher in BALB/c mice (mean ± SD 775 ± 100 fmoles/mg of DNA) than in untreated MRL‐lpr/lpr mice (80 ± 16 fmoles/mg of DNA) (P < 0.001). Treatment with 1% DFMO was associated with an increase in uterine estrogen receptor DNA binding (1,100 ± 218 fmoles/mg of DNA) in MRL‐lpr/lpr mice (P < 0.001). Polyamine levels were 2–6‐fold higher in the uterine tissues of untreated MRL‐lpr/lpr mice compared with the BALB/c mice and were significantly reduced by DFMO treatment. Our results link uterine polyamine production to a dysfunction of the estrogen receptors in MRL‐lpr/lpr mice. Reduction of the polyamine level by the irreversible inhibition of ornithine decarboxylase with DFMO restores estrogen receptor function.
Septic arthritis of the C1–C2 lateral facet joint and torticollis: Pseudo‐Grisel's syndrome
Authors: Halla James T. , Bliznak Johnny , Hardin Joe G. , Finn Sam 
Published: February 2007

AbstractWe present the case of a 76‐year‐old man who experienced the sudden development of fever, right‐sided neck pain and stiffness, and torticollis. A soft tissue mass was noted on the right side of his neck, but his head was tilted to the left. Computed tomography scans (with reformatted sagittal and coronal images) of the patient's cervical spine revealed destructive changes of the right lateral masses of C1 and C2 and the clivus, and a well‐delineated periodontoid soft tissue mass (confirmed by magnetic resonance imaging). After the second episode of right‐sided hemiparesis, he underwent transoral surgical exploration, with anterior decompression and odontoidectomy. Histologic examination of the surgical material revealed granulation tissue, fibrosis, and chronic inflammation, consistent with abscess formation with invasion and compression of the spinal cord and bone. This case suggests that nonreducible rotational head tilt to the side opposite the side of lateral mass collapse should raise the suspicion of a possible infection.
Persistence of monosodium urate crystals and low‐grade inflammation in the synovial fluid of patients with untreated gout
Authors: Pascual Eliseo 
Published: February 2007

AbstractSynovial fluid (SF) from 74 asymptomatic knees of patients with gout was analyzed. These patients had never been treated with serum uric acid‐lowering agents. SF samples were analyzed for the presence of crystals and for cell counts, using undiluted SF directly in a Niebauer cell counting chamber. Thirty‐seven of the aspirated knees had previously been inflamed, and monosodium urate (MSU) crystals were seen in SF aspirates from 36 of them (97%). Of the 37 knees that had never been inflamed, only 8 contained MSU crystals (P < 0.00001). After reaching the joint, MSU crystals will persist in the SF as long as the serum uric acid level has not been lowered by appropriate treatment. In this situation, analysis of SF is an excellent diagnostic test for the intercritical gout. The mean cell count in the 44 SF samples that contained MSU crystals was 449/mm3 (95% confidence interval 310–589); the mean cell count in the 30 SF without MSU crystals was 64/mm3 (95% confidence interval 34–95) (P < 0.00002). The SF samples that contained MSU crystals also had a higher percentage of polymorphonuclear leukocytes than those without MSU crystals (P < 0.002). These data suggest that there is a low‐grade inflammation present in the knees of patients with MSU crystals, the consequences of which should be investigated.
Local infectious complications following large joint replacement in rheumatoid arthritis patients treated with methotrexate versus those not treated with methotrexate
Authors: Perhala Robert S. , Wilke William S. , Clough John D. , Segal Allen M. 
Published: February 2007

AbstractWe performed a 10‐year retrospective analysis of the frequency of local postoperative infectious complications in methotrexate (MTX)‐treated rheumatoid arthritis patients who underwent total joint arthroplasty. Sixty patients, who had a total of 92 joint arthroplasties, were receiving MTX. A comparison group of 61 patients with a combined total of 110 total joint arthroplasties were not receiving MTX. The 2 groups were compared for the occurrence of local postoperative infectious complications and poor wound healing. Eight patients in the MTX group experienced a total of 8 complications (8.7% of procedures). In comparison, 5 patients in the non‐MTX group experienced a total of 6 complications (5.5% of procedures), a difference that was not statistically significant (χX2 = 0.816, P = 0.366). Statistical analysis of many other variables revealed none that could be identified as risk factors for postoperative complications. These results suggest that treatment in the perioperative period with weekly low‐dose pulse MTX does not increase the risk of local postoperative infectious complications or poor wound healing in rheumatoid arthritis patients who undergo total joint arthroplasty.
In vivo effects of nonsteroidal antiinflammatory drugs on rat skin and synovial mast cell–induced vasopermeability
Authors: Malone Daniel G. , Vikingsson Arnor , Seebruch Jane Servi , Verbsky James W. , Dolan Patricia W. 
Published: February 2007

AbstractUsing our animal model of synovial mast cell‐mediated arthritis in rats, we tested the effects of 3 nonsteroidal antiinflammatory drugs (NSAIDs) (aspirin, indomethacin, and ketoprofen) and an H1 and an H2 histamine receptor antagonist (diphenhydramine and cimetidine, respectively) on synovial and dermal mast cell‐induced vasopermeability. Drug effects were assessed by quantifying the leakage of radiolabeled albumin into tissues following specific antigen‐initiated activation of passively sensitized dermal and synovial mast cells. The 3 NSAIDs tested had different effects on synovial and dermal mast cell‐induced vasopermeability. Aspirin and indomethacin significantly increased dermal and synovial plasma exudation (P ⩽ 0.008). Ketoprofen decreased dermal (P = 0.015), but had no effect on synovial, vascular exudation. Complete histamine H1 and H2 receptor blockade with diphenhydramine and cimetidine, respectively, substantially decreased (P ⩽ 0.0008), but did not completely inhibit, dermal and synovial mast cell‐induced vasopermeability. However, the addition of indomethacin to the combined antihistamine regimen resulted in an increase in the leakage of the radiolabel into skin and synovium (back to control levels), despite the complete blockade of H1 and H2 receptors. Results of experiments with antihistamines and indomethacin suggest that mediators other than histamine are involved in synovial mast cell‐induced inflammation. Furthermore, the differential response to ketoprofen indicates that the specific antigen‐stimulated mediator release profiles of dermal and synovial mast cells are different. Our finding of enhanced synovial vascular leakage in animals treated with some NSAIDs, and no such effect by other NSAIDs, perhaps explains in part the diverse effects of these agents in humans with arthritis.
Spontaneous degenerative polyarthritis in male new zealand black/kn mice
Authors: Nakamura Kunie , Kashiwazaki Sadao , Takagishi Kenji , Tsukamoto Yukio , Morohoshi Yasuo , Nakano Takeshi , Kimura Masaaki 
Published: February 2007

AbstractHistopathologic studies and radiographic analysis revealed that male New Zealand black/KN (NZB/KN) mice develop degenerative polyarthritis in the joints of the forepaw and hindpaw beginning at age 2 months. Deposits of autoantibodies were observed on proliferating collagen fibers, nuclei of chondrocytes, and epidermal cells. Increases in the frequency of positivity for rheumatoid factor and anti‐type II collagen antibodies and in the level of serum oxidation activity were noted in these mice. The joint disease in male NZB/KN mice was transferable to female NZB/KN mice and male BALB/c mice by intraperitoneal injection of spleen cells from the male NZB/KN mice. This animal model of arthritis will be extremely useful for analyzing not only the pathogenesis of rheumatoid arthritis, but also new strategies for its treatment, since NZB/KN mice, unlike MRL/lpr mice, do not develop severe lupus nephritis or lymphadenopathy, and therefore have a longer survival period.
Clinical correlations with serum C1q levels in patients with rheumatoid arthritis
Authors: Olsen Nancy J. , Ho Edward , Barats Lev 
Published: February 2007

AbstractPrevious studies have suggested that serum C1q levels measured during the first 5 years of rheumatoid arthritis (RA) may be predictive of the extent of subsequent joint damage. To further evaluate the clinical significance of this marker in RA, levels of C1q were measured by radial immunodiffusion in serum samples from 107 well‐characterized patients with RA. Mean levels of C1q were higher in patients with a disease duration ⩽5 years (173 μg/ml) than in patients with a disease duration >5 years (148 μg/ml) (P = 0.032). Serum C1q levels were correlated with total joint counts and activities of daily living scores, but no correlation was observed with erythrocyte sedimentation rates or with radiographic scores. The results suggest that C1q may be a useful early marker of disease activity in patients with RA.
Wegener's granulomatosis presenting as temporal arteritis
Authors: Small Peter , Brisson Marie‐Laure 
Published: February 2007

AbstractA granulomatous giant cell vasculitis of the temporal artery was observed in a biopsy specimen from a patient with corresponding clinical symptoms. Within weeks, the new onset of pulmonary infiltrates and renal failure prompted biopsy of the patient's kidney. A necrotizing glomerulonephritis, compatible with a diagnosis of Wegener's granulomatosis, was present. Vasculitis of the temporal artery may be a feature of Wegener's granulomatosis.
Effects of lobenzarit disodium on human endothelial cells. Lobenzarit disodium inhibits proliferative response, HLA–DR antigen expression, and T cell adherence toward endothelial cells
Authors: Kawakami Atsushi , Eguchi Katsumi , Ueki Yukitaka , Migita Kiyoshi , Ida Hiroaki , Nakao Hideto , Kurata Akihiko , Fukuda Takaaki , Nagataki Shigenobu , Ishimaru Tadayuki , Kurouji Kenichi , Fujita Nagatoshi 
Published: February 2007

AbstractThe therapeutic action of lobenzarit disodium (CCA) on the function of endothelial cells (EC) isolated from human umbilical cord veins was investigated. CCA suppressed 3H‐thymidine incorporation into EC in a dose‐dependent manner. Significant inhibition was detected at a concentration of 50 μg/ml. The expression of HLA–DR antigen on the surface of EC was increased when EC were cultured with recombinant interferon‐γ (rIFNγ). Treatment of EC with either IFNγ or interleukin‐1 enhanced the adhesion of T cells to EC. The kinetics of HLA–DR antigen expression by EC cultured with IFNγ was different from the kinetics of T cell‐EC adhesion, however. Neither anti–HLA–DR nor anti–HLA–ABC monoclonal antibody inhibited T cell binding to EC monolayers. CCA suppressed the expression of HLA–DR antigen by EC cultured with rIFNγ. In an EC monolayer adhesion assay, CCA also inhibited T cell adhesion to EC in the presence of either IFNγ or interleukin‐1. Significant inhibition was observed at a CCA concentration of 10 μg/ml, a level that is easily attainable in serum. These results suggest that CCA may suppress rheumatoid synovitis by reducing the angiogenesis and emigration of chronic inflammatory cells from the blood into the synovium.
Crystal‐induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production by microcrystals
Authors: Naccache Paul H. , Grimard Marléne , Roberge Charles J. , Gilbert Caroline , Poubelle Patrice E. , Lussier André , De Médicis Rinaldo 
Published: February 2007

AbstractThe effects of monosodium urate and calcium pyrophosphate dihydrate crystals on the levels of cytoplasmic free calcium and on the oxidative burst in normal human blood neutrophils were examined. The pattern of sensitivity to granulocyte–macrophage colony‐stimulating factor, colchicine, cytochalasin B, pertussis toxin, diglyceride kinase, and protein kinase C inhibitors differentiated the mechanism(s) of neutrophil activation by the crystals from that involved in the responses to soluble chemotactic factors and indicated that individual crystals can use several activation pathways.
Hip arthropathy in genetic hemochromatosis. Radiographic and histologic features
Authors: Axford J. S. , Revell P. , Watt I. , Bomford A. , Williams R. , Hamilton E. B. D. 
Published: February 2007

AbstractGenetic hemochromatosis, a disorder of iron metabolism, results in the deposition of massive amounts of iron in the tissues. Arthropathy is one of a number of clinical features associated with the disease. Characteristic radiographic features in the wrist and hand have been reported, and an increased incidence of severe hip disease has been observed. In this study, hip radiographs of 112 patients with genetic hemochromatosis and arthritis were reviewed, and histologic examination of 2 femoral heads was performed. Twenty‐eight of the 112 patients (25%) had evidence of arthritis of the hip joint. In 23 (82%) of the 28 patients, this feature was thought to be associated with osteoarthritis; 2 of these patients had an atypical arthropathy associated with radiolucency of the femoral head and histologic features of atypical stripping of the cartilage from the subchondral bone. These atypical features were not thought to be due to avascular necrosis, pyrophosphate‐associated arthropathy, apatite‐associated deposition arthritis, or osteoarthritis, but may be typical of genetic hemochromatosis and possibly the result of increased susceptibility to shearing forces at the bone–cartilage interface. In 5 of the 28 patients (18%), chondrocalcinosis was the sole abnormal finding on radiography. Ten of the 28 patients eventually required hip surgery, which confirms the severity of the hip disease associated with genetic hemochromatosis.
Eosinophil activation in systemic sclerosis
Authors: Gustafsson Rolf , Hällgren Roger , Fredens Kjeld , Nettelbladt Otto 
Published: February 2007

AbstractCirculating levels of eosinophil cationic protein (ECP) were increased 4‐fold in patients with systemic sclerosis (SSc) compared with those in healthy control subjects. There was no correlation between the ECP concentrations and laboratory indices of inflammatory activity or visceral involvement. Mean ECP levels were higher in patients with a history of occupational exposure to silica, even though patients who had no such history also had ECP levels higher than normal. The patients had increased bronchoalveolar levels of ECP, which correlated with impaired lung functioning. Skin infiltration with activated eosinophils and extracellular deposits of ECP were present in skin biopsy samples from the SSc patients. We conclude that eosinophil activation is part of the inflammatory process in SSc.
Elimination of soluble 123I‐labeled aggregates of IgG in patients with systemic lupus erythematosus. Effect of serum IgG and numbers of erythrocyte complement receptor type 1
Authors: Halma Cornelis , Daha Mohamed R. , Evers‐Schouten Jeannette H. , van Es Leendert A. , Breedveld Ferdinand C. , Blok Dik , Hermans Jo , Pauwels Ernst K. J. 
Published: February 2007

AbstractUsing soluble 123I‐labeled aggregates of human IgG (123I‐AHIgG) as a probe, we examined the function of the mononuclear phagocyte system in 22 patients with systemic lupus erythematosus (SLE) and 12 healthy controls. In SLE patients, a decreased number of eryth‐rocyte complement receptor type 1 was associated with less binding of 123I‐AHIgG to erythrocytes and a faster initial rate of elimination of 123I‐AHIgG (mean ± SEM half‐maximal clearance time 5.23 ± 0.2 minutes, versus 6.58 ± 0.2 minutes in the controls), with possible spillover of the material outside the mononuclear phagocyte system of the liver and spleen. However, multiple regression analysis showed that serum concentrations of IgG were the most important factor predicting the rate of 123I‐AHIgG elimination. IgG concentration may thus reflect immune complex clearance, which in turn, would influence the inflammatory reaction, in SLE.
Enhanced CD3‐mediated T lymphocyte proliferation in patients with systemic lupus erythematosus
Authors: Stekman Ivan L. , Blasini Ana M. , Leon‐Ponte Matilde , Baroja Miren L. , Abadi Isaac , Rodriguez Martin A. 
Published: February 2007

AbstractNonfractionated peripheral blood lymphocytes from patients with systemic lupus erythematosus (SLE) showed enhanced proliferative responses when stimulated via the CD3 pathway. In contrast, proliferative responses induced by phytohemagglutinin were diminished in SLE patients. Levels of CD3‐induced interleukin‐2 production and interleukin‐2 receptor expression were comparable with normal levels. Highly purified T cells also showed augmented CD3 responses, but only in the presence of phorbol myristate acetate or a combination of phorbol myristate acetate plus calcium ionophore A23187, and not with calcium ionophore alone. The data suggest integrity of the T cell receptor/CD3 pathway for T cell activation in patients with SLE, as examined in cultures stimulated with specific anti‐CD3 monoclonal antibodies rather than with multivalent lectins. An increased response via the CD3 complex could contribute to the autoimmune activity in human SLE.
The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip
Authors: Altman R. , Alarcón G. , Appelrouth D. , Bloch D. , Borenstein D. , Brandt K. , Brown C. , Cooke T. D. , Daniel W. , Feldman D. , Greenwald R. , Hochberg M. , Howell D. , Ike R. , Kapila P. , Kaplan D. , Koopman W. , Marino C. , McDonald E. , McShane D. J. , Medsger T. , Michel B. , Murphy W. A. , Osial T. , Ramsey‐Goldman R. , Rothschild B. , Wolfe F. 
Published: February 2007

AbstractClinical criteria for the classification of patients with hip pain associated with osteoarthritis (OA) were developed through a multicenter study. Data from 201 patients who had experienced hip pain for most days of the prior month were analyzed. The comparison group of patients had other causes of hip pain, such as rheumatoid arthritis or spondylarthropathy. Variables from the medical history, physical examination, laboratory tests, and radiographs were used to develop different sets of criteria to serve different investigative purposes. Multivariate methods included the traditional “number of criteria present” format and “classification tree” techniques.Clinical criteria: A classification tree was developed, without radiographs, for clinical and laboratory criteria or for clinical criteria alone. A patient was classified as having hip OA if pain was present in combination with either 1) hip internal rotation ≥15º, pain present on internal rotation of the hip, morning stiffness of the hip for ≤60 minutes, and age >50 years, or 2) hip internal rotation <15º and an erythrocyte sedimentation rate (ESR) ≤45 mm/hour; if no ESR was obtained, hip flexion ≤115º was substituted (sensitivity 86%; specificity 75%).Clinical plus radiographic criteria: The traditional format combined pain with at least 2 of the following 3 criteria: osteophytes (femoral or acetabular), joint space narrowing (superior, axial, and/or medial), and ESR <20 mm/hour (sensitivity 89%; specificity 91%). The radiographic presence of osteophytes best separated OA patients and controls by the classification tree method (sensitivity 89%; specificity 91%).The “number of criteria present” format yielded criteria and levels of sensitivity and specificity similar to those of the classification tree for the combined clinical and radiographic criteria set. For the clinical criteria set, the classification tree provided much greater specificity. The value of the radiographic presence of an ostophyte in separating patients with OA of the hip from those with hip pain of other causes is emphasized.
Defective CD2 pathway T cell activation in systemic lupus erythematosus
Authors: Fox David A. , Millard Jo Ann , Treisman Jonathan , Zeldes Wendy , Bergman Alice , Depper Joel , Dunne Robert , McCune W. Joseph 
Published: February 2007

AbstractCD2 (T11; sheep erythrocyte receptor) is the surface component of an alternative, antigen‐independent pathway of human T cell activation. The response to certain anti‐CD2 antibodies is relatively independent of accessory cell signals and therefore provides a direct measurement of T cell function. The CD2 pathway may be important in the differentiation of thymocytes, on which the expression of CD2 precedes the appearance of the CD3–T cell receptor complex. In view of the impaired T cell regulation of immune responses in patients with systemic lupus erythematosus (SLE), we examined the activation of peripheral blood lymphocytes by anti‐CD2 antibodies in 57 SLE patients and 32 normal control subjects. The CD2 pathway response was lower in the SLE patients (P < 0.0001); 18 of the 57 SLE patients had a lower response than any of the control subjects. The SLE low‐responder patients did not differ from the normal‐responder patients in terms of disease activity or use of antiinflammatory and immunosuppressive medications. Low responses to anti‐CD2 were corrected to normal by the coaddition of a submitogenic amount of phorbol myristate acetate (1 ng/ml). In some low‐responder patients, the responses were normalized by the removal of non–T cells. The data indicate that some SLE patients have impaired responses to CD2 pathway activation and that this may reflect intrinsic T cell defects and/or regulatory influences of non–T cells.