bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilitarianism, Human Rights and the Redistribution of Health through Preventive Medical Measures
Authors: HÄYRY HETA , HÄYRY MATTI 
Published: February 2008

ABSTRACT  Public health authorities sometimes have to make decisions about the use of preventive medical measures—e.g. vaccination programmes—which could, if realised, save millions of lives, but could also kill a certain (small) number of those subjected to the measures. According to a rough‐and‐ready utilitarian calculation, such measures should be taken, but there are also possible objections to this view.A liberal objection to the use of mandatory preventive measures which might harm human beings is that people have a right to decide for themselves whether or not they want to participate in the programme. A further objection is based on the claims that first, the authorities are directly killing those who die because of, say, vaccination programmes, and second, directly killing human beings is forbidden (since every human being has a right to live).The latter objection is discussed at length in the present paper. The validity of three doctrines, the doctrines of the double effect, of acts and omissions, and of killing and letting die, are considered with reference to the use of preventive measures, and found inapplicable. The objection is, however, refuted by comparing some hypothetical examples, and the initial utilitarian calculation is reinforced.
Who are the Mentally Handicapped?
Authors: BODDINGTON PAULA , PODPADEC TESSA 
Published: February 2008

ABSTRACT In this paper we compare philosophical and contemporary psychological approaches to mental handicap. Careful comparison between the disciplines reveals major differences and indicates that much further work is needed which would be fruitful for both sides.The two disciplines concentrate on different questions: philosophy tends to look chiefly at mental handicap in relation to issues of personhood and is not very clear about what mental handicap is; psychology on the other hand is much more specific about mental handicap, but shows little concern with critically examining value issues. Our main intention is to explore the different ways in which mental handicap is defined and seen as a class.We conclude that class definition embodies a significant normative component and a large element of social construction. To ignore this and attempt to make normative judgements on the basis of class membership is thus highly problematic. Since within philosophy, these normative issues are often discussed in terms of personhood, this category is also critically examined and the conclusion is reached that it too has normative and social components which can lead to ethically dubious judgements being made about ‘the mentally handicapped’.
Complexity and the Value of Lives—some philosophical dangers for mentally handicapped people
Authors: FAIRBAIRN GAVIN J. 
Published: February 2008

ABSTRACT In his book The End of Life James Rachels argues that in a situation of forced choice if we must choose between a more and a less complex human being we have good reason to choose in favour of the normal human. He argues also that since some humans have less complex mental abilities than some animals it will sometimes be right to choose a non‐human animal in preference to a human being.I do not consider Rachels’belief that sometimes non‐human animals are to be preferred to retarded humans; I focus rather on the seemingly less contentious belief that in situations of forced choice, we should choose human beings with more rather than less complex lives. I reject this contention both because Rachels does not seem to have offered a worthwhile argument in its favour and also because I find his cavalier approach to the lives of people with intellectual disabilities morally offensive. En route I argue against his simplistic separation of human lives into the categories ‘simple’and ‘complex’on the basis of whether the individuals in question fall into what he seems to take as given—the clear cut categories ‘mentally retarded’and ‘normal’[1] [2].
Freedom and Respect in a Multicultural Society
Authors: NAYLOR FRED 
Published: February 2008

ABSTRACT Martin Hollis, in Market Equality and Social Freedom [1], used the Dewsbury case to illustrate the tension between individual freedom and the public good. Like others engaged in the public debate on multicultural education in general, and Dewsbury in particular, Hollis avoided the main issue: “What should be the curriculum in a school attended by pupils from different cultural backgrounds?’’Rational debate in this highly controversial area requires an analysis of two fundamental concepts—multicultural education and respect. The former can take three forms, each corresponding with a distinctive curriculum model. One—the Equality option—is inimical to parental rights as guaranteed under the European Convention, but it attracts support because of a widespread failure to recognise that one can respect someone's right to hold and propagate a particular faith (or opinion) without necessarily respecting that faith (or opinion).It is shown that this failure has come about through very lax usage of ‘respect’. It is argued that by respecting persons whatever their values the potential conflict between liberty and equality can be resolved in a free society.
Community and the Rights of Future Generations: a reply to Robert Elliot
Authors: DE‐SHALIT AVNER 
Published: February 2008

ABSTRACT It is widely recognised that we hold certain moral obligations to future generations. Robert Elliot argues that we can base these obligations on the rights of future people. I accept his argument that future people are moral agents who possess rights. However, I argue that the main question for political and moral philosophers is whether it is possible to find the balance between the obligations to, and the rights of, contemporaries, and the obligations to, and the rights of, future people.By analysing the notions of ‘human rights’and ‘welfare rights’of future people, I argue that this question can be tackled only in terms of welfare rights. But the latter make sense only in the context of community of provision. This implies that we must first examine the ‘trans‐generational’community that includes contemporaries and future generations. Thus a theory of justice between generations cannot be purely ‘rights‐based’. However, by describing the ‘trans‐generational community’I argue that it can serve as the moral grounds for our obligations to future generations.
Ethnic Diversity and the Nation State
Authors: JAYAL NIRAJA GOPAL 
Published: February 2008

ABSTRACT The coterminality of nation and state is the central legitimising principle of the modern state, which has recently come to be challenged by a variety of ethnic groups across the world. This essay identifies two such challenges: (a) The Claim of Alternative Statehood, which endorses the coterminality of cultural and political community, challenges the political boundaries of existing nation‐states, and grounds its secessionist demands in a more precise congruence between nationality and state; and (b) The Claim of Alternative Citizenship, which does not threaten the nation‐state, and seeks only protection for the special requirements of cultural community, for which it demands autonomy, agency and rights. Both types of challenge tend to submerge the individual, as they uphold the rival claims of states and cultural communities.It is argued that the failed promise of pluralism in modern multi‐ethnic societies demands a rethinking of the notion of citizenship. Extending citizenship from its location in polity/state to society as such, and providing space for affiliative and affinitive identities in addition to filiative ones, may help to strengthen civil society, within a non‐majoritarian and non‐homogenising political framework.
Ways of Knowing: The Creative Process and the Design of Technology
Authors: GLYNN SIMON 
Published: February 2008

ABSTRACT This paper draws upon the already extensive epistemology of science, both to provide a yardstick of comparison for the emergent epistemology of design, and to establish some starting points from which we might begin to construct the epistemology of design.In approaching the problem of how designers design, the paper employs Heidegger's distinction between ‘know‐how’and ‘knowledge‐that’, popularised by Ryle, and shows it to be central to the distinction between the implicit processes of design employed by craft technologies, and the explicit processes employed by modern scientific technology. Borrowing from recent work by post‐structuralists, it explores the nature of the phases of analysis or ‘deconstruction’, synthesis or construction, and evaluation, by which scientifically informed design is supposed to proceed, paying particular attention to the relationship between deconstructive analysis and constructive synthesis, in order to re‐construct the creative moment/movement by which designers ‘leap’ from problem to solution.
Urban Preservation and the Judgment of Solomon
Authors: De Shalit Avner 
Published: February 2008

ABSTRACT Facing heretofore unknown waves of new immigrants, the Israeli Government and the mayor of Jerusalem issued a comprehensive development programme, including rapid and massive construction. Cities with historical and aesthetic uniqueness, particularly Jerusalem, are likely to lose their special features and beauty. A question is raised: how can an argument in favour of conservation of the special beauties of such cities be advanced in light of the urgent need to supply shelter and jobs for their inhabitants?The paper has two aims: to analyse the reasons for environmental ethics'failure to discuss urban preservation so far, and to put forward a rationale for urban preservation. The latter derives from the political wisdom of King Solomon and from the notion of anthropocentric intrinsic value.
Freedom of Speech and the Public Platform
Authors: TEICHMAN JENNY 
Published: February 2008

ABSTRACT The paper has to do with Peter Singer's statement ‘A German Attack on Applied Ethics’, and particularly with the claim that those who protested against his speaking at conferences in Europe in 1989 failed to recognise his right to freedom of expression.I argue that the right to free expression does not mean that we may say anything at all, to anyone at all, anywhere at all. Visitors to foreign countries, for example, have some obligation to be sensitive to local concerns.I also argue that there is an important difference between free expression, which is a basic right, and regular access to public platforms, which is a special right or privilege. This special right or privilege goes with certain jobs and professions, and could not be made universal. The German and Austrian protests against Singer temporarily deprived him of the privilege of access to a platform but were not attacks on the basic right of free speech as such. In fact the protests themselves could be regarded as a legitimate exercise of the right of free expression.
Evolutionary Ethics and the Status of Non‐Human Animals
Authors: RODD ROSEMARY 
Published: February 2008

ABSTRACT If we accept that the behaviour of humans and other animals is very substantially channelled by evolutionary constraints, it might appear that there can be no place for animals within the protection of a human system of morality.However, the nature of plausible evolutionary constraints on the cognition of social animals, including humans, suggests that this is not so. It is likely that the most important element in our morality is the capacity to imagine the feelings of other individuals, and this capacity is so important for our ability to understand and predict their behaviour that it would be likely to be preserved by evolution even if moral behaviour had no survival value in its own right. We also use this kind of imaginative sympathy to understand and predict the behaviour of other animals, and it is this which provides the main reason for the inclusion of such animals within a human moral system. The primitive elements of morality have a survival value that is probably common to many other social species of animals. Since one of our reasons for putting a special value on human life is the human capacity for moral behaviour, we ought also to view members of these species as being of special significance.
Aboriginal Right: A Conciliatory Concept
Authors: MORITO BRUCE 
Published: February 2008

The confusion that persists over Aboriginal claim in North America calls for close examination. The paper begins by sorting out various versions of ‘Aboriginal right’and some of the main factors that govern its use. Confusion is analysed as the result of conflating different frames of reference which determine different sets of expectations by Aboriginal and government representatives.To appreciate the significance of this conflation, it is helpful if not necessary to view the move to use the concept ‘Aboriginal right’as a strategic rather than a legally substantive one. Understanding the move in this way helps to explain why it is that definitions remain elusive. The effect of using the concept has indeed been to enable Aboriginals finally and effectively to table their claim. However, the strategy has its cost. Using the language of the courts places Aboriginal negotiators at a disadvantage, since that language is ineluctably tied to European social and legal sensibilities that militate against understanding Aboriginal claim.If, in the end, we understand that the move to use the language of the courts has been conciliatory, we can better recognise the nature of Aboriginal claim. We can begin to understand that it involves a complex web of responsibilities and commitments, most of which have either been forgotten or perverted to suit government agendas. We can begin to see that it has to do with restoring a relationship of mutual respect and protection.
What is Philosophical in Philosophical Counselling?
Authors: LAHAV RAN 
Published: February 2008

After a short description of the nature of philosophical counselling, this paper suggests that what makes philosophical counselling philosophical is that it helps the counsellee in philosophical self‐investigations. These are critical non‐empirical investigations of the fundamental principles underlying the counsellee's ‘lived understanding’(i.e. conceptions which the counsellee lives by, though not necessarily articulates in words), aimed at the development of wisdom.In order to illustrate the nature of philosophical self‐investigation, two case studies are presented. The nature and measurability of success in philosophical counselling is then discussed. A questionnaire filled out by a counsellee is quoted as an illustration of the possible effects and success of philosophical counselling.
Philosophical Counselling, Truth and Self‐Interpretation
Authors: JOPLING DAVID A. 
Published: February 2008

Philosophical counselling, Ran Lahav and others claim, helps clients deepen their philosophical self‐understanding. The counsellor's role is the minimalist one of providing the client with the philosophical tools needed for reflective self‐evaluation. Respect for the client's autonomy entails refraining from intervening with substantive moral criticism, theories, and methods; the client's ways of working out fundamental questions like ‘Who am I and what do I really want?’cannot be assessed by the counsellor in terms of their truth‐value, but only in terms of whether they reflect the client's autonomous choice to express him/herself in a certain way.I argue that this view, which is informed by an anti‐realist account of self and life‐history, undermines the distinction between self‐knowledge and self‐deception. Once interpretive and criteriological free rein is given to the client, and once personal, pragmatic and aesthetic considerations take precedence over truth‐value, then the way is left open to clients to generate the most morally convenient self‐interpretation to suit their current needs.I defend the view that truth matters in philosophical counselling; more specifically, that there is a basic distinction between true and false forms of self‐understanding. To do this, I offer a broadly realist account of self and reflective self‐evaluation. If this is right, then philosophical counsellors shoulder a significant burden of responsibility in helping their clients achieve an accurate, defensible, action‐guiding and truth‐oriented self‐understanding.
Assessment of post‐mortem‐induced changes to the mouse brain proteome
Authors: Hunsucker Stephen W. , Solomon Benjamin , Gawryluk Jeremy , Geiger Jonathan D. , Vacano Guido N. , Duncan Mark W. , Patterson David 
Published: February 2008

AbstractThis study was designed to assess the influence of high‐energy head‐focused microwave irradiation and the post‐mortem interval on measurements of the mouse brain proteome. Difference gel electrophoresis was used to compare mouse brain protein levels in animals killed by decapitation, where the tissue was held at 25°C for selected time intervals post‐mortem, and by high‐energy head‐focused microwave irradiation followed by immediate resection. Microwave‐mediated killing was used because it comprehensively snap‐inactivates enzymes while largely retaining brain cytoarchitecture. Of the 912 protein spots common to at least eight of 10 gels analyzed, 35 (3.8%) showed significant differences in levels (t‐test; p < 0.05) depending on whether animals were killed by microwave irradiation or decapitation. When animals were killed by decapitation, 43 protein spots (4.7%) showed changes in levels over the post‐mortem interval (anova; p < 0.05). The vast majority of the near 1000 proteins evident on a 2D gel were stable for up to 4 h. These data have important implications for studies of proteins in the brain, whether based on analysis of tissue derived from animal models or from humans.
Host‐cell specific effects of the nicotinic acetylcholine receptor chaperone RIC‐3 revealed by a comparison of human and Drosophila RIC‐3 homologues
Authors: Lansdell Stuart J. , Collins Toby , Yabe Arisa , Gee Veronica J. , Gibb Alasdair J. , Millar Neil S. 
Published: February 2008

AbstractRIC‐3 is a transmembrane protein which enhances maturation (folding and assembly) of neuronal nicotinic acetylcholine receptors (nAChRs). In this study, we report the cloning and characterisation of 11 alternatively spliced isoforms of Drosophila melanogaster RIC‐3 (DmRIC‐3). Heterologous expression studies of alternatively spliced DmRIC‐3 isoforms demonstrate that nAChR chaperone activity does not require a predicted coiled‐coil domain which is located entirely within exon 7. In contrast, isoforms containing an additional exon (exon 2), which is located within a proline‐rich N‐terminal region, have a greatly reduced ability to enhance nAChR maturation. The ability of DmRIC‐3 to influence nAChR maturation was examined in co‐expression studies with human α7 nAChRs and with hybrid nAChRs containing both Drosophila and rat nAChR subunits. When expressed in a Drosophila cell line, several of the DmRIC‐3 splice variants enhanced nAChR maturation to a significantly greater extent than observed with human RIC‐3. In contrast, when expressed in a human cell line, human RIC‐3 enhanced nAChR maturation more efficiently than DmRIC‐3. The cloning and characterisation of 11 alternatively spliced DmRIC‐3 isoforms has helped to identify domains influencing RIC‐3 chaperone activity. In addition, studies conducted in different expression systems suggest that additional host cell factors may modulate the chaperone activity of RIC‐3.
A broadly neuroprotective derivative of curcumin
Authors: Liu Yuanbin , Dargusch Richard , Maher Pamela , Schubert David 
Published: February 2008

AbstractThe plant polyphenolic curcumin alters the response of nerve cells to some forms of toxic stress. The steroid‐like compound, cyclohexyl bisphenol A, has broad neuroprotective properties that are very distinct from those of curcumin. To incorporate both families of biological activities into a single molecule, a pyrazole derivative of curcumin, called CNB‐001, was synthesized. CNB‐001 acquires a new activity and is far superior in neuroprotection assays to either parental molecule, but retains some of the properties of both. It is neuroprotective in cell culture assays for trophic factor withdrawal, oxidative stress, excitotoxicity, and glucose starvation, as well as toxicity from both intracellular and extracellular amyloid. While the creation of CNB‐001 was based upon an uncommon approach to drug design, it has the potential of a lead drug candidate for treating multiple conditions involving nerve cell death.
Minocycline neuroprotects, reduces microglial activation, inhibits caspase 3 induction, and viral replication following Japanese encephalitis
Authors: Mishra Manoj Kumar , Basu Anirban 
Published: February 2008

AbstractMinocycline is broadly protective in neurological disease models featuring inflammation and cell death and is being evaluated in clinical trials. Japanese encephalitis virus (JEV) is one of the most important causes of viral encephalitis worldwide. There is no specific treatment for Japanese encephalitis (JE) and no effective antiviral drugs have been discovered. Studies indicate that JE involves profound neuronal loss as well as secondary inflammation caused because of cell death. Minocycline is a semisynthetic second‐generation tetracycline that exerts anti‐inflammatory and antiapoptotic effects that are completely separate from its antimicrobial action. Because tetracycline treatment is clinically well tolerated, we investigated whether minocycline protects against experimental model of JE. Intravenous inoculation of GP78 strain of JEV in adult mice results in lethal encephalitis and caused primarily because of neuronal death and secondary inflammation caused because of cell death. Minocycline confers complete protection in mice following JEV infection (p < 0.0001). Neuronal apoptosis, microglial activation, active caspase activity, proinflammatory mediators, and viral titer were markedly decreased in minocycline‐treated JEV infected mice on ninth day post‐infection. Treatment with minocycline may act directly on brain cells, because neuronal cell line Neuro2a were also salvaged from JEV‐induced death. Our data suggest that minocycline may be a candidate to consider in human clinical trials for JE patients.