bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Development of Site Specific Gene Delivery System with Sonoporation
Authors: Suzuki Ryo , Oda Yusuke , Namai Eisuke , Takizawa Tomoko , Negishi Yoichi , Utoguchi Naoki , Tachibana Katsuro , Maruyama Kazuo 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Principles of Protein—Protein Interactions: What Are the Preferred Ways for Proteins to Interact?
Authors: Keskin Ozlem , Gursoy Attila , Ma Buyong , Nussinov Ruth 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Review of Estimation Models for Biodegradation
Authors: Pavan Manuela , Worth Andrew P. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Minireview of Available Skin Sensitization (Q)SARs/Expert Sytems
Authors: Patlewicz Grace , Aptula Aynur O. , Roberts David W. , Uriarte Eugenio 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Review of (Quantitative) Structure—Activity Relationships for Acute Aquatic Toxicity
Authors: Netzeva Tatiana I. , Pavan Manuela , Worth Andrew P. 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Isotope Effect on Chemical Shifts in Hydrogen‐Bonded Systems
Authors: Hansen Poul Erik 
Published: June 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Arthur von Weinberg: Wissenschaftler, Unternehmer, Mäzen, NS‐Opfer
Authors: Stolleis Michael 
Published: June 2008

AbstractIm öffentlichen Bewusstsein sind die Brüder Arthur und Carl von Weinberg vielleicht wenig präsent. Aber bei den ehemaligen “Cassellanern”, in der Universität, im “Senckenberg”, im “Städel”, in der Frankfurter Gesellschaft für Handel, Industrie und Wissenschaft, bei den Leitern von Zoo oder Palmengarten, auf dem Rennplatz in Niederrad oder im dortigen Golfclub weiß man sehr wohl, wer die Brüder von Weinberg waren. Es sei versucht, die Geschichte der Familie Weinberg, insbesondere die von Arthur von Weinberg, aus fünf verschiedenen Perspektiven wenigstens anzudeuten.
Arthur von Weinberg: Chemiker, Naturforscher
Authors: Vollmann Hansjörg W. 
Published: June 2008

AbstractDer aus der Industriellenfamilie Cassella – Gans – Weinberg stammende Chemiker Dr. Arthur von Weinberg hat, gemeinsam mit seinem Onkel Dr. Leo Gans und seinem Bruder Carl von Weinberg, die kleine, 1870 gegründete Farbenfabrik seines Onkels durch grundlegende, wissenschaftliche Erkenntnisse in der Naphthalinchemie und deren praktische Umsetzung um 1890 zur größten Azofarbenfabrik der Welt werden lassen. Er erkannte frühzeitig die Wichtigkeit der billig zu produzierenden Schwefelfarbstoffe, ebenso die wirtschaftliche Bedeutung von synthetischen Arzneimitteln. Für seine Verdienste um die chemische Industrie wurde er 1908 – zusammen mit seinem Bruder Carl – geadelt; seine Heimatstadt Frankfurt/Main ernannte den vielseitig tätigen Mäzen anlässlich seines 70ten Geburtstages zu ihrem 10. Ehrenbürger. Die Nationalsozialisten deportierten den 82 Jahre alten Chemiker in das Konzentrationslager Theresienstadt, wo er 1943 verstarb.
Effekte von Nikotin sind rezeptorabhängig
Authors: Welter Kira 
Published: June 2008

AbstractNikotin gehört zu den Substanzen mit dem höchsten Suchtpotential. Nach Einschätzungen der Weltgesundheitsorganisation (WHO) gibt es mehr als 1.3 Milliarden Raucher weltweit – Tendenz steigend. Nun hoffen Forscher aus den USA und der Schweiz, dass ihre neuesten Erkenntnisse zur Entwicklung besserer Therapien im Kampf gegen die Nikotinabhängigkeit beitragen. Sie haben herausgefunden, dass die kurz‐ und langfristigen Änderungen im Nikotinspiegel eines Rauchers unterschiedliche Rezeptoren‐Subtypen im Körper beeinflussen.
Baumring‐Kalender reicht zurück bis in die letzte Eiszeit
Authors: Feil Sylvia 
Published: June 2008

AbstractGletschereis und Baumringe sind natürliche Archive, die Rückschlüsse auf das Klima vergangener Jahrtausende ermöglichen. Nun gelang es, beide miteinander zu verknüpfen: Der exakte Baumring‐Kalender erweitert sich durch die Kombination mit dem Eisbohrkern‐Archiv und reicht nun bis 14.000 Jahre vor unserer Zeit zurück und damit in das Ende der letzten Eiszeit. Hierzu korrelierte eine internationale Forschergruppe um Raimund Muscheler von der Universität Lund, an der auch Forscher um Michael Friedrich von der Universität Hohenheim und der Heidelberger Akademie der Wissenschaften beteiligt waren, Beryllium aus Eisbohrkernen mit Radiokohlenstoff aus Baumringen.
External beam irradiation and the combination of cisplatin and carmustine followed by carmustine alone for the treatment of high‐grade glioma
Authors: Blumenthal Deborah T. , Rankin Cathryn , Eyre Harmon J. , Livingston Robert B. , Spence Alexander M. , Stelzer Keith J. , Rushing Elisabeth J. , Berger Mitchel S. , Rivkin Saul E. , Cohn Allen L. , Petersdorf Stephen H. 
Published: June 2008

AbstractBACKGROUND.The poor prognosis reported for patients with high‒grade glial neoplasms indicates a need for the development of multimodality therapeutic approaches. The addition of chemotherapy has contributed variably to increased survival. The objective of the current study (Southwest Oncology Group [SWOG] 9016) was to determine whether concurrent radiotherapy and chemotherapy with the combination of carmustine and cisplatin could be given safely in a cooperative group setting. Additional objectives included the estimation of response rate, the rate of disease stabilization, and the probability of 1‐year survival.METHODS.SWOG 9016 study included 59 eligible patients with grade III or IV astrocytoma who received radiotherapy concurrently with carmustine/cisplatin chemotherapy. Patients were required to have either measurable or evaluable disease. The therapeutic endpoints were comprised of complete response (CR), partial response (PR), or progressive disease (PD).RESULTS.Six patients achieved a CR (CR rate of 10%; 95% confidence interval [95% CI], 4–21%), 4 achieved a PR (PR rate of 7%; 95% CI, 2–16%), and 2 patients (3%) experienced an unconfirmed response. Twenty‐four patients (41%; 95% CI, 28–54%) had stable disease and 10 patients (17%) demonstrated PD. The overall disease stabilization rate (CR + PR + stable disease, excluding unconfirmed response) was 58% (95% CI, 44–70%).CONCLUSIONS.Despite the presence of a cohort of long‒term survivors, the results of the current study do not appear to support the additional studyor routine use of concurrent cisplatin and carmustine. Cancer 2008. © 2008 American Cancer Society.
Adjuvant treatments do not alter the quality of life in elderly patients with colorectal cancer
Authors: Bouvier Anne‐Marie , Jooste Valérie , Bonnetain Franck , Cottet Vanessa , Bizollon Marie‐Hélène , Bernard Marie‐Pierre , Faivre Jean 
Published: June 2008

AbstractBACKGROUND.The current study was performed to longitudinally assess the impact of adjuvant treatments on the quality of life (QoL) of elderly colorectal cancer survivors.METHODS.The Burgundy Digestive Cancer Registry was used to select all patients aged ≥75 years who were diagnosed with colorectal cancer between 2003 and 2005. A total of 209 patients were asked to complete questionnaires during the first year after diagnosis: at the time of inclusion in the study (Q0), at 3 months after the initial diagnosis (Q3), at 6 months after the initial diagnosis (Q6), and at 12 months after the initial diagnosis (Q12) using the European Organization for Research and Treatment of Cancer (EORTC) QLQ‐C30. A total of 125 patients (60%) responded. Mixed model analyses of variance for repeated measurement were used to compare QoL scores according to therapeutic schemes. Interactions between time of follow‐up and treatment were tested.RESULTS.Patient sex, age, location of the tumor, and TNM stage of disease did not appear to differ significantly between respondents and nonrespondents. Global Health and Emotional Functioning improved for colon cancer survivors between Q0 and Q12, and were noted to improve between Q3 and Q12 for rectal cancer patients. According to French recommendations, patients who received chemotherapy for stage III colon cancer (P = .176) or radiotherapy for rectal cancer (P = .959) reported no significant changes in Global Health compared with those patients not receiving adjuvant therapies. Patients treated with chemotherapy reported better Physical Functioning than patients who did not received chemotherapy (P = .0113).CONCLUSIONS.To the authors' knowledge, the current study is the first to examine trends over time with regard to the influence of adjuvant treatments for colon and rectal cancers on QoL in a general aged population. Providing evidence that adjuvant chemotherapy for colon cancer has no negative impact on the QoL of elderly patients is of great significance in encouraging clinicians to treat this population. Cancer 2008. © 2008 American Cancer Society.
Length‐Dependent Conductance of Molecular Wires and Contact Resistance in Metal–Molecule–Metal Junctions
Authors: Liu Hongmei , Wang Nan , Zhao Jianwei , Guo Yan , Yin Xing , Boey Freddy Y. C. , Zhang Hua 
Published: June 2008

AbstractMolecular wires are covalently bonded to gold electrodes—to form metal–molecule–metal junctions—by functionalizing each end with a SH group. The conductance of a wide variety of molecular junctions is studied theoretically by using first‐principles density functional theory (DFT) combined with the nonequilibrium Green′s function (NEGF) formalism. Based on the chain‐length‐dependent conductance of the series of molecular wires, the attenuation factor β is obtained and compared with the experimental data. The β value is quantitatively correlated to the molecular HOMO–LUMO gap. Coupling between the metallic electrode and the molecular bridge plays an important role in electron transport. A contact resistance of 6.0±2.0 KΩ is obtained by extrapolating the molecular‐bridge length to zero. This value is of the same magnitude as the quantum resistance.
Electrochemical Oxidation of Dopamine in the Presence of Secondary Amine. An Alternative Way for Quantitative Dopamine Determination at a Gold Electrode
Authors: Łuczak Teresa 
Published: June 2008

AbstractElectrooxidation of dopamine in the absence and presence of morpholine as a nucleophile was investigated on a gold electrode in phosphate buffer, pH 7. The results have shown that electrochemically produced dopaminoquinone undergoes an attack by morpholine via 1,4‐Michael addition. The reaction products have been identified by electrospray ionization mass spectrometry (ESI‐MS). The procedure used is suitable for quantitative dopamine determination in the presence of the ascorbic acid excess at a unmodified gold electrode.
TiC Working Electrode. Voltammetric Characteristics and Application for Determination of Lead Traces by Stripping Voltammetry
Authors: Baś B. , Piech R. , Niewiara E. , Ziemnicka M. , Stobierski L. , Kubiak W. W. 
Published: June 2008

AbstractThe TiC working electrode was tested as a novel, potential electrode for anodic stripping voltammetric determination of lead(II) ions traces. To demonstrate the practical applicability of the TiC electrode, an underpotential deposition/dissolution (UPD) phenomena system in electrolyte without removal of oxygen was tested. The electrode was constructed be means of mounting a TiC disk (Ø=3.5 mm) in a resin body. Three compositions of TiC were tested differing in stoichiometry, namely TiC0.6, TiC0.8, and TiC1.0. The key problem is the method of electrochemical activation of the TiC electrode. No or improperly activated electrode is not polarized and is unsuitable as a voltammetric sensor. The TiC electrode was used for the determination of Pb2+ in concentrations ranging from 1 to 100 nM. The instrumental parameters, composition of supporting electrolyte and procedures of the electrode activation were optimized. The repeatability of DP ASV runs in synthetic solutions covering the entire concentration range is better than 3%. The calibration curve is characterized by a correlation coefficient of at least 0.999. The detection limit was 2 nM for an electrodeposition time of 30 s. The method enables determination of Pb2+ in the presence of, among the others, high excesses of Cd, Cu, In, Sb, Se, and Tl ions as well as surfactants, Triton X‐100 and humic acids. The analysis of Pb2+ in synthetic solutions with and without surfactants, certified reference material and natural water samples have been performed. The voltammetric data were associated with the structural characterization of the electrode surface using scanning electron microscopy (SEM) and X‐ray fluorescence spectroscopy (XRF).
Ruthenium Oxide Hexacyanoferrate Modified Electrode for Hydrogen Peroxide Detection
Authors: Paixão Thiago R. L. C. , Bertotti Mauro 
Published: June 2008

AbstractA sensor for H2O2 amperometric detection based on a Prussian blue (PB) analogue was developed. The electrocatalytic process allows the determination of hydrogen peroxide at 0.0 V with a limit of detection of 1.3 μmol L−1 in a flow injection analysis (FIA) configuration. Studies on the optimization of the FIA parameters were performed and under optimal FIA operational conditions the linear response of the method was extended up to 500 μmol L−1 hydrogen peroxide with good stability. The possibility of using the developed sensor in medium containing sodium ions and the increased operational stability constitute advantages in comparison with PB‐based amperometric sensors. The usefulness of the methodology was demonstrated by addition‐recovery experiments with rainwater samples and values were in the 98.8 to 103% range.
Maximum likelihood estimators of population parameters from multiply censored samples
Authors: Aboueissa Abou El‐Makarim A. 
Published: June 2008

AbstractLeft‐censored data often arise in environmental contexts with one or more detection limits (DLs). Estimators of the parameters are derived for left‐censored data having multiple detection limits: DL1, DL2,…, DLk(k ≥ 3) assuming an underlying normal distribution. New method for calculating the maximum likelihood estimates (MLE) is given and examined for these cases. This method also applies to lognormally distributed environmental data with multiple distinct DLs. The performance of the new estimators is compared utilizing many simulated datasets. Examples are given illustrating the use of this method utilizing a computer program whose code is given in the Appendix section. Copyright © 2008 John Wiley & Sons, Ltd.
On surface tension modelling using the level set method
Authors: Shepel Sergey V. , Smith Brian L. 
Published: June 2008

AbstractThe paper describes and compares the performance of two options for numerically representing the surface tension force in combination with the level set interface‐tracking method. In both models, the surface tension is represented as a body force, concentrated near the interface, but the technical implementation is different: the first model is based on a traditional level set approach in which the force is distributed in a band around the interface using a regularized delta function, whereas in the second, the force is partly distributed in a band around the interface and partly localized to the actual computational cells containing the interface. A comparative study, involving analysis of several two‐phase flows with moving interfaces, shows that in general the two surface tension models produce results of similar accuracy. However, in the particular case of merging and pinching‐off of interfaces, the traditional level set model of surface tension produces an error that results in non‐converging solutions for film‐like interfaces (i.e. ones involving large contact areas). In contrast, the second model, based on the localized representation of the surface tension force, displays consistent first‐order convergence. Copyright © 2008 John Wiley & Sons, Ltd.
Slip effects and heat transfer analysis in a viscous fluid over an oscillatory stretching surface
Authors: Abbas Z. , Wang Y. , Hayat T. , Oberlack M. 
Published: June 2008

AbstractIn this study, we investigate the heat transfer problem in a viscous fluid over an oscillatory infinite sheet with slip condition. The sheet is moved back and forth in its own plane. The derived problem involves a dimensionless parameter indicating the relative magnitude of frequency to sheet stretching rate. A system of non‐linear partial differential equations is solved numerically using the finite‐difference scheme, in which a coordinate transformation is employed to transform the semi‐infinite physical space to a bounded computational domain. The physical features of interesting parameters on the velocity and temperature distributions are shown graphically and discussed. The values of the skin‐friction coefficient and the local Nusselt number are given in tabular form. Copyright © 2008 John Wiley & Sons, Ltd.
A hybrid building‐block and gridless method for compressible flows
Authors: Luo Hong , Baum Joseph D. , Löhner Rainald 
Published: June 2008

AbstractA hybrid building‐block Cartesian grid and gridless method is presented to compute unsteady compressible flows for complex geometries. In this method, a Cartesian mesh based on a building‐block grid is used as a baseline mesh to cover the computational domain, while the boundary surfaces are represented using a set of gridless points. This hybrid method combines the efficiency of a Cartesian grid method and the flexibility of a gridless method for the complex geometries. The developed method is used to compute a number of test cases to validate the accuracy and efficiency of the method. The numerical results obtained indicate that the use of this hybrid method leads to a significant improvement in performance over its unstructured grid counterpart for the time‐accurate solution of the compressible Euler equations. An overall speed‐up factor from six to more than one order of magnitude and a saving in storage requirements up to one order of magnitude for all test cases in comparison with the unstructured grid method are demonstrated. Copyright © 2008 John Wiley & Sons, Ltd.
Healing of shock instability for Roe's flux‐difference splitting scheme on triangular meshes
Authors: Phongthanapanich Sutthisak , Dechaumphai Pramote 
Published: June 2008

AbstractHealing of nonphysical flow solutions and shock instability from the use of Roe's flux‐difference splitting scheme is presented. The proposed method heals nonphysical flow solutions such as the carbuncle phenomenon, the shock instability from the odd–even decoupling problem, and the expansion shock generated from the violated entropy condition. The performance and efficiency of the proposed method are evaluated by solving several benchmark and complex high‐speed compressible flow problems. Copyright © 2008 John Wiley & Sons, Ltd.
Seasonal prediction of European cereal prices: good forecasts using bad models?
Authors: Jumah Adusei , Kunst Robert M. 
Published: June 2008

AbstractBecause of their natural adherence to the climate and pronounced seasonal cycles, prices of field crops constitute an interesting field for exploring seasonal time series models. We consider quarterly prices of two major cereals: barley and wheat. Using traditional in‐sample fit and moving‐window techniques, we investigate whether seasonality is deterministic or unit‐root stochastic and whether seasonal cycles have converged over time. We find that seasonal cycles in the data are mainly deterministic and that evidence on common cycles across countries differs for the two commodities. Out‐of‐sample prediction experiments, however, yield a ranking with respect to accuracy that does not match the statistical in‐sample evidence. Parametric bootstrap experiments establish that the observed mismatch is indeed an inherent and systematic feature. Copyright © 2008 John Wiley & Sons, Ltd.
Molecular and transcriptional characterization of 17p loss in B‐cell chronic lymphocytic leukemia
Authors: Fabris Sonia , Mosca Laura , Todoerti Katia , Cutrona Giovanna , Lionetti Marta , Intini Daniela , Matis Serena , Colombo Monica , Agnelli Luca , Gentile Massimo , Spriano Mauro , Callea Vincenzo , Festini Gianluca , Molica Stefano , Lambertenghi Deliliers Giorgio , Morabito Fortunato , Ferrarini Manlio , Neri Antonino 
Published: June 2008

AbstractDistinct genetic abnormalities, such as TP53 deletion at 17p13.1, have been identified as having adverse prognostic relevance in B‐cell chronic lymphocytic leukemia (B‐CLL), and conventional cytogenetic studies have shown that TP53 deletion in B‐CLL is mainly associated with the loss of 17p due to complex chromosomal rearrangements. We used an integrative genomic approach to investigate the significance of 17p loss in 18 B‐CLLs in Binet stage A, carrying a TP53 monoallelic deletion detected by means of fluorescence in situ hybridization (FISH). Genome‐wide DNA analysis using single nucleotide polymorphism (SNP) arrays of 12 of 18 samples showed 17p loss in 11 cases, with breakpoints scattered along the 17p11.2 region. FISH analysis confirmed these findings and revealed 17p loss in a small fraction of leukemic cells in the remaining TP53‐deleted case, and it also indicated 17p loss in the six cases not investigated by means of SNP arrays. Mutations in exons 2–11 of the remaining TP53 allele were found in 9 of 12 deleted samples. Gene‐expression profiling of 60 B‐CLLs, including seven patients with 17p loss, identified 40 differentially expressed genes in 17p‐ versus 17p normal samples, 35 of which were downregulated in 17p‐tumors. The majority (30 of 35) of these transcripts, including putative tumor suppressor genes, mapped to 17p, thus indicating a remarkable gene‐dosage effect. Our data provide evidence that 17p loss may play an additional pathogenetic role in B‐CLL and suggest that the concomitant loss of multiple tumor suppressor genes could be responsible for the highly adverse prognostic relevance associated with TP53 loss. © 2008 Wiley‐Liss, Inc.