bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ferried Albumin‐Inspired Bioadhesive With Dynamic Interfacial Bonds for Emergency Rescue
Authors: Chen Yiming , Li Huiying , Xu Renfeng , Fang Yan , Chen Qinhui , Wang Zhengchao , Liu Haiqing , Weng Yunxiang 
Published: March 2024

AbstractEmergency prehospital wound closure and hemorrhage control are the first priorities for life‐saving. Majority of bioadhesives form bonds with tissues through irreversible cross‐linking, and the remobilization of misalignment may cause severe secondary damage to tissues. Therefore, developing an adhesive that can quickly and tolerably adhere to traumatized dynamic tissue or organ surfaces in emergency situations is a major challenge. Inspired by the structure of human serum albumin (HSA), a branched polymer with multitentacled sulfhydryl is synthesized, then, an instant and fault‐tolerant tough wet‐tissue adhesion (IFA) hydrogel is prepared. Adhesive application time is just 5 s (interfacial toughness of ≈580 J m−2), and favorable tissue‐adhesion is maintained after ten cycles. IFA hydrogel shows unchangeable adhesive performance after 1 month of storage based on the internal oxidation–reduction mechanism. It not only can efficiently seal various organs but also achieves effective hemostasis in models of the rat femoral artery and rabbit‐ear artery. This work also proposes an effective strategy for controllable adhesion, enabling the production of asymmetric adhesives with on‐demand detachment. Importantly, IFA hydrogel has sound antioxidation, antibacterial property, hemocompatibility, and cytocompatibility. Hence, the HSA‐inspired bioadhesive emerges as a promising first‐aid supply for human–machine interface‐based health management and non‐invasive wound closure.
Topologically Protected Quantum Logic Gates with Valley‐Hall Photonic Crystals
Authors: He Lu , Liu Dongning , Zhang Huizhen , Zhang Furong , Zhang Weixuan , Feng Xue , Huang Yidong , Cui Kaiyu , Liu Fang , Zhang Wei , Zhang Xiangdong 
Published: March 2024

AbstractTopological photonics provide a promising way to realize more robust optical devices against some defects and environmental perturbations. Quantum logic gates are fundamental units of quantum computers, which are widely used in future quantum information processing. Thus, constructing robust universal quantum logic gates is an important way forward to practical quantum computing. However, the most important problem to be solved is how to construct the quantum‐logic‐gate‐required 2 × 2 beam splitter with topological protection. Here, the experimental realization of the topologically protected contradirectional coupler is reported, which can be employed to realize the quantum logic gates, including control‐NOT and Hadamard gates, on the silicon photonic platform. These quantum gates not only have high experimental fidelities but also exhibit a certain degree of tolerances against certain types of defects. This work paves the way for the development of practical optical quantum computations and signal processing.
Photothermal Actuation of Thick 3D‐Printed Liquid Crystalline Elastomer Nanocomposites
Authors: Skillin Nathaniel P. , Bauman Grant E. , Kirkpatrick Bruce E. , McCracken Joselle M. , Park Kyoungweon , Vaia Richard A. , Anseth Kristi S. , White Timothy J. 
Published: March 2024

AbstractLiquid crystalline elastomers (LCEs) are stimuli‐responsive materials that transduce an input energy into a mechanical response. LCE composites prepared with photothermal agents, such as nanoinclusions, are a means to realize wireless, remote, and local control of deformation with light. Amongst photothermal agents, gold nanorods (AuNRs) are highly efficient converters when the irradiation wavelength matches the longitudinal surface plasmon resonance (LSPR) of the AuNRs. However, AuNR aggregation broadens the LSPR which also reduces photothermal efficiency. Here, the surface chemistry of AuNRs is engineered via a well‐controlled two‐step ligand exchange with a monofunctional poly(ethylene glycol) (PEG) thiol that greatly improves the dispersion of AuNRs in LCEs. Accordingly, LCE‐AuNR nanocomposites with very low PEG‐AuNR content (0.01 wt%) prepared by 3D printing are shown to be highly efficient photothermal actuators with rapid response (>60% strain s−1) upon irradiation with near‐infrared (NIR; 808 nm) light. Because of the excellent dispersion of PEG‐AuNR within the LCE, unabsorbed NIR light transmits through the nanocomposites and can actuate a series of samples. Further, the dispersion also allows for the optical deformation of millimeter‐thick 3D printed structures without sacrificing actuation speed. The realization of well‐dispersed nanoinclusions to maximize the stimulus‐response of LCEs can benefit functional implementation in soft robotics or medical devices.
Electrical Doping of Metal Halide Perovskites by Co‐Evaporation and Application in PN Junctions
Authors: Schramm Tim , Deconinck Marielle , Ji Ran , Siliavka Elena , Hofstetter Yvonne J. , Löffler Markus , Shilovskikh Vladimir V. , Brunner Julius , Li Yanxiu , Bitton Sapir , Tessler Nir , Vaynzof Yana 
Published: March 2024

AbstractElectrical doping of semiconductors is a revolutionary development that enabled many electronic and optoelectronic technologies. While doping of many inorganic and organic semiconductors is well‐established, controlled electrical doping of metal halide perovskites (MHPs) is yet to be demonstrated. In this work, efficient n‐ and p‐type electrical doping of MHPs by co‐evaporating the perovskite precursors alongside organic dopant molecules is achieved. It is demonstrated that the Fermi level can be shifted by up to 500 meV toward the conduction band and by up to 400 meV toward the valence band by n‐ and p‐doping, respectively, which increases the conductivity of the films. The doped layers are employed in PN and NP diodes, showing opposing trends in rectification. Demonstrating controlled electrical doping by a scalable, industrially relevant deposition method opens the route to developing perovskite devices beyond solar cells, such as thermoelectrics or complementary logic.
Non‐Hermitian Broadside Coupled Split Ring Resonators with Directional Sensitivity
Authors: Sun Zhenci , Zhao Xiaoguang , Zhang Lingyun , Liang Chao , Li Bingbai , Lu Wenshuai , Zhang Wenqiang , You Rui , Zhao Jiahao , You Zheng 
Published: March 2024

AbstractDirectional radiofrequency (RF) sensing, also known as radio direction finding, is essential in various applications that involve localizing RF sources. However, existing RF sensing technologies face challenges due to their large antenna sizes and complex RF signal processing circuits, which hinder the realization of miniaturized subwavelength direction sensors. In this article, a non‐Hermitian broadside coupled split ring resonators (BC‐SRRs) are presented, which can identify the direction of an incident RF signal with angles ranging from 0° to 180°. The non‐Hermitian Hamiltonian of the system, which can be interpreted by the temporal coupled mode theory, gives rise to asymmetric resonant modes of the BC‐SRRs. The asymmetry allows the direct measurement of RF wave incident angle by probing the resonant strength of the two BC‐SRRs. For the proof of concept, a one‐stage Dickson voltage multiplier is employed to rectify the RF signals and demonstrate angle sensing ability by relating the rectified voltage to the incident angle. The results showcase the potential of the proposed technique using non‐Hermitian BC‐SRRs as a pathway toward subwavelength antenna‐based radio direction finding.
Construction of Circular Polarized Luminescence Molecules for Intense Near Infrared OLEDs
Authors: Liang Ning , Liu Jianxun , Lin Yufan , Xie Zeling , Cui Bin‐Bin , Gong Zhong‐Liang , Gan Qiang , Zhong Yu‐Wu , Feng Yansong , Yao Chang‐Jiang 
Published: March 2024

AbstractThe exploration of organic near‐infrared (NIR) luminescence, along with circularly polarized luminescence (CPL), is of vital importance due to its significance in medical and optoelectronic applications. Integrating a chiral unit into a D–A molecular structure in this research realized emission peaks at 744 nm, exhibiting a dissymmetric factor of −1.67 × 10−3. The introduced chiral TPA derivative not only imparts aggregation‐induced emission properties and CPL capabilities but also induces a redshift in the emission spectrum. Consequently, the fabricated NIR organic light‐emitting devices (OLEDs), achieve maximum electroluminescent peaks at 748 nm in nondoped devices with the external quantum efficiency of 13.7% in doped devices. This pioneering research provides inspiration for the design of NIR molecules possessing CPL properties in the future, particularly in promoting the application of intense NIR‐OLEDs.
Unveiling All‐Optical Switching Phenomenon in Anthracene Derivatives: A Comprehensive Study on Optical and Nonlinear Optical Multifunctionality
Authors: Szukalski Adam , Zajac Dorota , Pardus Natasza , Karout Houda El , Krawczyk Przemyslaw , Sahraoui Bouchta 
Published: March 2024

AbstractIn this study, it is considered three anthracene derivatives, characterized meticulously in terms of their chemical structure and product purity. Extensive quantum chemical calculations are conducted to elucidate their optical and nonlinear optical properties, shedding light on the mechanism of photoinduced conformational transformation, a pivotal discovery in this research. Experimental analyses encompassed fundamental optical properties and advanced nonlinear optical phenomena, including z‐scan experiments, second harmonic generation (SHG), and third harmonic generation (THG). Remarkably, a groundbreaking all‐optical switching phenomenon in these materials is experimentally validated, marking a significant advancement and contributing to their potential applications.
High‐Efficiency Short‐Wave Infrared Emitter Enabled by Cr3+–Yb3+ Co‐Doped Phosphor
Authors: Shi Ruiqi , Miao Shihai , Lv Xulong , Chen Dongxun , Zhang Yi , Liang Yanjie 
Published: March 2024

AbstractThe utilization of phosphor‐converted light‐emitting diodes (pc‐LEDs) as compact short‐wave infrared (SWIR) emitters has emerged as a promising strategy for miniature SWIR spectrometers in portable devices, enabling diverse applications such as nondestructive identification, bioimaging, night‐vision surveillance, and optical communication. However, discovering phosphors capable of efficiently absorbing blue light and emitting pure SWIR light (>900 nm) remains a significant challenge. Here, highly efficient and thermally stable SWIR luminescence of Yb3+ upon blue LED excitation by employing Cr3+–Yb3+ energy transfer in Y3Ga5O12 garnet is reported. The prepared Y3Ga5O12:Cr3+,Yb3+ phosphor exhibits intense SWIR emission spanning from 900 to 1150 nm at 438 nm excitation, coupled with ultra‐high internal/external quantum efficiency of 80.8%/40.2% and excellent luminescence thermal stability (108%@150 °C). A SWIR pc‐LED prototype fabricated by incorporating the optimized phosphor with a commercial 450 nm blue LED chip, shows exceptional SWIR luminescence performance, delivering a SWIR output power of 92.7 mW at a driving current of 350 mA and a photoelectric efficiency of 21.5% at 10 mA. This work opens up a new avenue for designing SWIR phosphors that exhibit efficient and thermally stable photoluminescence with blue LED excitation, demonstrating significant potential for next‐generation high‐power compact SWIR light sources.
Electron‐Deficient Boron‐Doped g‐C3N4 as an Efficient and Robust Photocatalyst for Visible‐Light Driven Hydrogen Evolution from Water Splitting
Authors: Ullah Ikram , Lu Xiao‐Jie , Chen Shuai , Li Jing‐Han , Habib Sadia , Murtaza Ghulam , Tofaz Tania , Xu An‐Wu 
Published: March 2024

AbstractElemental doping is considered to be a promising approach for altering the electronic structure, optical absorbance, and charge separation characteristics of graphitic carbon nitride (g‐C3N4, termed as CN), thus boosting its photocatalytic performance for practical applications. Herein, a series of boron (B) doped g‐C3N4 (named as BCN) photocatalysts are developed via one‐step pyrolysis of a mixture of urea and 3‐methoxycarbonyl‐5‐nitriophenylboronic acid (MCNPBA). The results show that B‐atoms have been successfully incorporated into the g‐C3N4 network. The as‐synthesized BCN‐x (x shows the weight content of MCNPBA) photocatalysts are evaluated in photocatalytic hydrogen (H2) evolution from water splitting under visible‐light (λ ≥ 420 nm). The optimized BCN‐10 sample shows a maximum H2 evolution rate of 1789.93 µmol h─1 g─1, which is 6.2 times higher than that of g‐C3N4 (289.73 µmol h─1 g─1). This is attributed to the fact that the electron‐deficient B‐atoms are lewis acids that trap electrons, which in turn expands visible‐light absorption, narrows the bandgap, and prevents the recombination of photogenerated charge carriers. Moreover, B‐doping can readily modify the valence and conduction band positions of g‐C3N4, therefore augmenting the photocatalytic H2 evolution activity. This paper presents a unique rational framework for developing other functionalized electron‐deficient elemental‐doping g‐C3N4‐based photocatalysts for practical applications in solar‐to‐fuel conversion.
A Bioinspired Immunostimulatory System for Inducing Powerful Antitumor Immune Function by Directly Causing Plasma Membrane Rupture
Authors: Hu Xiaoqu , Yin Hao , Xie Danli , Chen Tanzhou , Li Yida , Zeng Hanqian , Lu Mingdong , Wang Qinyang 
Published: March 2024

AbstractThe Gasdermin protein is a membrane disruptor that can mediate immunogenic pyroptosis and elicit anti‐tumor immune function. However, cancer cells downregulate Gasdermin and develop membrane repair mechanisms to resist pyroptosis. Therefore, an artificial membrane disruptor (AMD) that can directly mediate membrane rupture in pyroptosis‐deficient cells and induce antitumor immune responses in a controllable manner will be valuable in preclinical and clinical research. A micron‐scale Ce6‐based AMD that can directly induce plasma membrane rupture (PMR) in gasdermin‐deficient tumor cells is established. Micron‐scale AMDs localize Ce6 specifically to the plasma membrane without labeling other organelles. Compared to free Ce6 molecules, the use of AMDs results in a higher degree of specificity for the plasma membrane. Due to this specificity, AMDs mediate fast and irreversible PMR under 660 nm red light. Furthermore, the AMDs are capable of inducing programmed cell death and lytic cell death in a catalytic manner, demonstrating that the amount of Ce6 used by AMDs is only one‐fifth of that used by Ce6 alone when inducing 80% of cancer cell death. In vivo, the AMDs show specificity for tumor targeting and penetration, suggesting that light‐driven programmed cell death is specific to tumors. AMDs are applied to antitumor therapy in gasdermin‐deficient tumors, resulting in efficient tumor elimination with minimal damage to major organs when combined with anti‐PD‐1 therapy. Tumor regression is correlated with PMR‐mediated inflammation and T‐cell‐based immune responses. This study provides new insights for designing bioinspired membrane disruptors for PMR and mediating anti‐tumor immunotherapy. Additionally, AMD is a dependable tool for examining the immunogenicity of PMR both in vitro and in vivo.
In Situ Formation of Fibronectin‐Enriched Protein Corona on Epigenetic Nanocarrier for Enhanced Synthetic Lethal Therapy
Authors: Luo Zhangyi , Wan Zhuoya , Ren Pengfei , Zhang Bei , Huang Yixian , West Raymond E. , Huang Haozhe , Chen Yuang , Nolin Thomas D. , Xie Wen , Wang Junmei , Li Song , Sun Jingjing 
Published: March 2024

AbstractPARP inhibitors (PARPi)‐based synthetic lethal therapy demonstrates limited efficacy for most cancer types that are homologous recombination (HR) proficient. To potentiate the PARPi application, a nanocarrier based on 5‐azacytidine (AZA)‐conjugated polymer (PAZA) for the codelivery of AZA and a PARP inhibitor, BMN673 (BMN) is developed. AZA conjugation significantly decreased the nanoparticle (NP) size and increased BMN loading. Molecular dynamics simulation and experimental validations shed mechanistic insights into the self‐assembly of effective NPs. The small PAZA NPs demonstrated higher efficiency of tumor targeting and penetration than larger NPs, which is mediated by a new mechanism of active targeting that involves the recruitment of fibronectin from serum proteins following systemic administration of PAZA NPs. Furthermore, it is found that PAZA carrier sensitize the HR‐proficient nonsmall cell lung cancer (NSCLC) to BMN, a combination therapy that is more effective at a lower AZA/BMN dosage. To investigate the underlying mechanism, the tumor immune microenvironment and various gene expressions by RNAseq are explored. Moreover, the BMN/PAZA combination increased the immunogenicity and synergized with PD‐1 antibody in improving the overall therapeutic effect in an orthotopic model of lung cancer (LLC).
Constructing FeNiPt@C Trifunctional Catalyst by High Spin‐Induced Water Oxidation Activity for Zn‐Air Battery and Anion Exchange Membrane Water Electrolyzer
Authors: Pan Yangdan , Li Yuwen , Nairan Adeela , Khan Usman , Hu Yan , Wu Baoxin , Sun Lu , Zeng Lin , Gao Junkuo 
Published: March 2024

AbstractDeveloping cost‐efficient trifunctional catalysts capable of facilitating hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and oxygen reduction reaction (ORR) activity is essential for the progression of energy devices. Engineering these catalysts to optimize their active sites and integrate them into a cohesive system presents a significant challenge. This study introduces a nanoflower (NFs)‐like carbon‐encapsulated FeNiPt nanoalloy catalyst (FeNiPt@C NFs), synthesized by substituting Co2+ ions with high‐spin Fe2+ ions in Hofmann‐type metal‐organic framework, followed by carbonization and pickling processes. The FeNiPt@C NFs catalyst, characterized by its nitrogen‐doped carbon‐encapsulated metal alloy structure and phase‐segregated FeNiPt alloy with slight surface oxidization, exhibits excellent trifunctional catalytic performance. This is evidenced by its activities in HER (−25 mV at 10 mA cm−2), ORR (half‐wave potential of 0.93 V), and OER (294 mV at 10 mA cm−2), with the enhanced water oxidation activity attributed to the high‐spin state of the Fe element. Consequently, the Zn‐air battery and anion exchange membrane water electrolyzer assembled by FeNiPt@C NFs catalyst demonstrate remarkable power density (168 mW cm−2) and industrial‐scale current density (698 mA cm−2 at 1.85 V), respectively. This innovative integration of multifunctional catalytic sites paves the way for the advancement of sustainable energy systems.
Regio‐ and Chemoselective Palladium‐Catalyzed Additive‐Free Direct C─H Functionalization of Heterocycles with Chloroaryl Triflates Using Pyrazole‐Alkyl Phosphine Ligands
Authors: Gu Changxue , So Chau Ming 
Published: March 2024

AbstractA series of new pyrazole‐alkyl phosphine ligands with varying cycloalkyl ring sizes that enable additive‐free regio‐ and chemoselective C─H arylation of heterocycles are reported. Excellent α/β selectivity of various heterocycles such as benzo[b]thiophene, thiophene, furan, benzofuran, and thiazole can be achieved using these ligands, along with excellent chemoselectivity of C─Cl over C─OTf of chloroaryl triflates. Mechanistic studies supported by both experimental findings and density functional theory calculations indicate that the pyrazole phosphine ligands with optimal ring sizes allow the reaction to proceed with a lower energy barrier via a concerted metalation–deprotonation pathway.
Discovery of Novel Anti‐Resistance AR Antagonists Guided by Funnel Metadynamics Simulation
Authors: Chen Haiyi , Zhou Yuxin , Wang Xinyue , Chai Xin , Wang Zhe , Wang Ercheng , Xu Lei , Hou Tingjun , Li Dan , Duan Mojie 
Published: March 2024

AbstractAndrogen receptor (AR) antagonists are widely used for the treatment of prostate cancer (PCa), but their therapeutic efficacy is usually compromised by the rapid emergence of drug resistance. However, the lack of the detailed interaction between AR and its antagonists poses a major obstacle to the design of novel AR antagonists. Here, funnel metadynamics is employed to elucidate the inherent regulation mechanisms of three AR antagonists (hydroxyflutamide, enzalutamide, and darolutamide) on AR. For the first time it is observed that the binding of antagonists significantly disturbed the C‐terminus of AR helix‐11, thereby disrupting the specific internal hydrophobic contacts of AR‐LBD and correspondingly the communication between AR ligand binding pocket (AR‐LBP), activation function 2 (AF2), and binding function 3 (BF3). The subsequent bioassays verified the necessity of the hydrophobic contacts for AR function. Furthermore, it is found that darolutamide, a newly approved AR antagonist capable of fighting almost all reported drug resistant AR mutants, can induce antagonistic binding structure. Subsequently, docking‐based virtual screening toward the dominant binding conformation of AR for darolutamide is conducted, and three novel AR antagonists with favorable binding affinity and strong capability to combat drug resistance are identified by in vitro bioassays. This work provides a novel rational strategy for the development of anti‐resistant AR antagonists.
Autonomous Magnetic Navigation in Endoscopic Image Mosaics
Authors: Mattille Michelle , Boehler Quentin , Lussi Jonas , Ochsenbein Nicole , Moehrlen Ueli , Nelson Bradley J. 
Published: March 2024

AbstractEndoscopes navigate within the human body to observe anatomical structures with minimal invasiveness. A major shortcoming of their use is their narrow field‐of‐view during navigation in large, hollow anatomical regions. Mosaics of endoscopic images can provide surgeons with a map of the tool's environment. This would facilitate procedures, improve their efficiency, and potentially generate better patient outcomes. The emergence of magnetically steered endoscopes opens the way to safer procedures and creates an opportunity to provide robotic assistance both in the generation of the mosaic map and in navigation within this map. This paper proposes methods to autonomously navigate magnetic endoscopes to 1) generate endoscopic image mosaics and 2) use these mosaics as user interfaces to navigate throughout the explored area. These are the first strategies, which allow autonomous magnetic navigation in large, hollow organs during minimally invasive surgeries. The feasibility of these methods is demonstrated experimentally both in vitro and ex vivo in the context of the treatment of twin‐to‐twin transfusion syndrome. This minimally invasive procedure is performed in utero and necessitates coagulating shared vessels of twin fetuses on the placenta. A mosaic of the vasculature in combination with autonomous navigation has the potential to significantly facilitate this challenging surgery.