bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement in the Effective Cataract Surgical Coverage in Malaysia: Evidence of Impact from a Mobile Cataract Outreach Program
Authors: Salowi Mohamad Aziz , Naing Nyi Nyi , Mustafa Norasyikin , Nawang Wan Radziah Wan , Sharudin Siti Nurhuda , Husni Mohd Aziz 
Published: March 2024

Abstract
Background
Effective Cataract Surgical Coverage (eCSC) is one of the Universal Health Coverage (UHC) indicators recommended by the World Health Organization (WHO). It is calculated from a population survey and measures access and quality of eye care services in the community. We conducted simultaneous population-based eye surveys in two regions in Malaysia in 2023 to estimate eCSC and compare the results with the survey in 2014 following the implementation of a mobile cataract program.
Methods
The surveys were simultaneously done in Eastern and Sarawak administrative regions using the Rapid Assessment of Avoidable Blindness (RAAB) technique. It involved a multistage cluster sampling method, each cluster comprising 50 residents aged 50 years and older. Presenting visual acuity (PVA) was checked and subjects with cataract were identified. The corrected VA (Pinhole) of those who had undergone cataract surgery was measured. eCSC was calculated at all levels of cataract surgical thresholds according to the protocol. The findings were compared with the previous survey.
Results
Females had a significantly lower Cataract Surgical Coverage (CSC) than males for cataract surgical threshold of < 3/60 for both regions in National Eye Survey (NES) II in 2014, [Eastern female 82.0%, 95%CI (72.5, 91.5) vs male 97.8%, 95%CI (92.8, 100.0), Sarawak female 76.9%, 95%CI (66.4, 87.3) vs male 96.4%, 95%CI (91.6, 100.0%)]. Although the values for eCSC were lower than CSC during both surveys, the difference between genders was insignificant. Comparing NES II (2014) and NES III (2023) at various levels of cataract surgical threshold, eCSC improved within the range of 13.8%-19.2% and 18.6%-23.8% for Eastern and Sarawak respectively.
Conclusion
The improvement in eCSC could be attributed to the impact of the mobile cataract service in both regions. However, a coordinated approach is necessary to further strengthen and expand the coverage of the program to enable the country to achieve the 30% increase in eCSC as targeted by WHO.
miR-455-3p has superior diagnostic potential to PSA in peripheral blood for prostate cancer
Authors: Cen Yi , Feng Shourui , Xu Yuyu , Zhang Churuo , Lin Xiangjin , Ye Xuan , Zha Zeyu , Wang Haiyan , Zhu Guangbin 
Published: March 2024

Abstract
Background
Prostate-specific antigen (PSA) is commonly used as a biomarker to diagnose and predict the course of prostate cancer (PCa). However, PSA detection is susceptible to changes in the physiologic environment, which may lead to some misdiagnosis. Thus, it is crucial to find a novel diagnostic marker.
Methods
We accessed microRNA (miRNA) expression datasets (GSE206793 and GSE112264) from the GEO database, analyzing peripheral blood samples from PCa patients. Differentially expressed miRNAs (DEmiRNAs) were identified using GEO2R. A specific miRNA, miR-455-3p, was pinpointed through rigorous analysis of clinical correlations and ROC curves. Peripheral blood samples from healthy individuals and PCa patients were subjected to qRT-PCR validation, aligning results with the GSE206793 dataset. The miRWalk database was utilized to predict downstream genes, while STRING facilitated the construction of a protein-protein interaction (PPI) network. KEGG pathway analysis enriched our understanding of potential molecular pathways.
Results
We found that miR-455-3p was highly expressed in the peripheral blood of PCa patients with Gleason score (GS) ≥ 8, while independent of T stage, age and PSA. ROC analysis revealed a favorable diagnostic efficacy of miR-455-3p and AUC for the two datasets was respectively 0.943 and 0.847. The qRT-PCR assay also revealed consistent results. Interestingly, the PSA levels of P1 (GS = 5 + 4) and P6 (GS = 3 + 3) were respectively 3.38 and 4.45 ng/ml, while miR-455-3p was highly expressed in both, suggesting its low misdiagnosis. The speculation was validated in GSE206793 dataset. Finally, 9 potential targets of miR-455-3p were predicted. PPI network revealed PPP2R2A, ITGB1 and CDKN1A as key nodes. KEGG pathway analysis revealed that they were enriched in various cancers, biological processes and molecular signals.
Conclusion
Our study identifies miR-455-3p as a promising diagnostic marker for PCa, outperforming PSA in terms of specificity and sensitivity. The robustness of miR-455-3p, coupled with its potential downstream targets and associated pathways, highlights its clinical significance for improved PCa diagnosis and management.
Effects of a single session of isometric handgrip exercise on blood pressure in hypertensive women: a randomized crossover trial
Authors: Barros Rebeca Lima Rego , Oliveira Marcelo Santana , Silva Jefferson Maxwell Farias , Kanegusuku Helcio , Correia Marilia Almeida , Ritti-Dias Raphael Mendes , Farah Breno Quintella 
Published: March 2024

Abstract

Background: While there are consistent chronic reductions in blood pressure following an extended period of isometric training, the acute effects exhibit notable variation. These results suggest potential variability in individual responses to exercise, emphasizing the need to investigate whether various factors, such as age, medications, among others, can account for these diverse responses.
Aim: The aims of this study were to analyze acute blood pressure responses after isometric handgrip exercise and to identify factors associated with responsiveness in hypertensive women.
Methods: 18 medicated hypertensive women were randomly allocated to perform two experimental sessions: Handgrip (4[two on each arm] x 2-min set at 30% of their maximal voluntary contraction) or Sham (the same protocol as the handgrip session, but with an anti-stress ball, without any isometric component). Pre-and post-interventions (Post 15’, Post30’, Post45’ and Post60’) resting blood pressure was evaluated. Average and interindividual responses for handgrip session were analyzed, while the linear regression was used to identify factors associated with responsiveness.
Results: No significant changes were observed in systolic and diastolic blood pressure after both the Handgrip and Sham sessions (p>0.05). Interindividual variation was 3.6 mmHg for systolic blood pressure and 1.6 mmHg for diastolic blood pressure. Half of hypertensive women experienced a reduction in systolic blood pressure above 4 mmHg. Age, body mass index, pre-intervention blood pressure, and medications were not found to be predictors of these responses (p>0.05). Conclusion: Isometric handgrip exercise did not reduce blood pressure reduction in hypertensive women, although 50% reduced systolic blood pressure.
Spatial and temporal distribution and health effects of microcystins in Dianshan lake located in east China
Authors: Yu Xi , Shen Yan , Diao Yongqing , Hu Jielan , Yao Xinmin , Li Yuxin , Shao Weiai , Shi Le 
Published: March 2024

Abstract
To investigate the eutrophication status and evaluate health risks of Dianshan Lakewhich located in Qingpu district，Shanghai. We monitored the source water in Dianshan lake for five different sites during 2021. The source water quality and eutrophication, algal toxin pollution status, health risks of the population were investigated through continuous monitoring of the water source of Dianshan Lake. We found the water quality of Dianshan Lake changed with the seasons, and the moderate eutrophication was mainly manifested by excessive nitrogen and phosphorus concentrations, which was better than previous survey. Liver and kidney function in the population exposed to water contaminated with algal toxins and ingestion of contaminated fish showed changes compared to the control community. After all , we think the water quality of Dianshan Lake is better than previous monitoring, which is mainly manifested in excessive nitrogen and phosphorus concentrations, algal toxin pollution in summer and autumn in the lake area, which has certain health risks.
Predicting viral gastroenteritis epidemic using sewage
Authors: Furuya Daisuke , Yajima Tomomi , Indo Tomokazu , Yokoyama Toru , Sugawara Toshitsugu , Nakamura Minoru , Takahashi Satoshi 
Published: March 2024

Abstract
Viral gastroenteritis caused by Caliciviruses is found all over the world. This study aims to estimate the number of people infected with viral gastroenteritis based on the virus concentration in sewage collected from sewage treatment plants in 11 major cities in Hokkaido. Norovirus GI and GII were detected in all plants (11/11, 100%) and Sapovirus in 9 plants (9/11, 82%), with concentrations of Norovirus GI, GII, and Sapovirus ranging from 536 to 78,087 copies/L, 99,586 to 5,476,257 copies/L, and 0 to 18,767,409 copies/L, respectively. We constructed a formula to estimate the number of people infected with viral gastroenteritis based on the virus concentration in sewage, the processing capacity of sewage treatment plants, the fecal volume and viral concentration of infected people. Evaluated by this formula, the estimated number of infected people ranged from 367 to 33,563. The number of cases reported per sentinel is affected by the size of the population treated by the sewage treatment plant and lacks accuracy, and a discrepancy was confirmed from the estimated number of infected people. This study demonstrated that by using the developed calculation formula, it is possible to estimate the number of people infected with viral gastroenteritis based on the virus concentration in sewage, and that it is useful in understanding the actual situation of the epidemic.
Optimizing the Resilience of the Fresh Agricultural Product Supply Chain Considering Supply Chain Disruptions
Authors: Geng Nana , Lu Yang 
Published: March 2024

Abstract
Due to the unique characteristics of fresh agricultural products and the disruptions caused by unforeseen events, the supply chain for fresh agricultural products is highly vulnerable to the risks of supply chain interruptions. To ensure its stability and sustainable development, it is essential to conduct optimization research on the supply chain network. This article analyzes the types of interruptions in the supply chain of fresh agricultural products and proposes three targeted resilient strategies. Focusing on the fresh agricultural product supply chain with agricultural wholesale markets at its core, a resilient optimization model considering supply chain interruptions is constructed. An improved NSGA-II algorithm is also designed to solve the model. Finally, the correctness of the model is validated using the case of the Nanjing Agricultural Wholesale Market. The results indicate that the application of resilient strategies not only reduces the supply chain costs by around 11% but also significantly enhances the resilience of the supply chain.
Stipe of the kelp Eisenia bicyclis as a long-lasting carbon sink
Authors: Putra Delta , Suzuki Haruka , Aoki Masakazu N. 
Published: March 2024

Abstract

Eisenia bicyclis is a dominant stipitate understory canopy-forming kelp on the Pacific coast of Japan. It is perennial and individuals live for approximately 8 years. While the blades of E. bicyclis are gradually renewed, the stipes are constantly present to support the blades and have been observed to persist for some time after the loss of blades or detachment of the holdfast. Therefore, the stipe may function as a long-lasting carbon sink. However, there have been few attempts to quantify the carbon contribution of stipes to the coastal environment. In this study, field experiments were conducted to investigate the contribution of stipes to carbon storage. Pieces of stipe (N = 6) ca 8 cm long were cut from E. bicyclis thalli and suspended at a depth of 3 m in a sheltered, subtidal rocky shore environment at Kitsunezaki, Oshika Peninsula, Japan. Changes in the morphology, wet weight and carbon content of these stipes were recorded for two-month periods at about two-week intervals. The experiments were conducted at three different times of the year: Experiment I was conducted in Jun-Aug, 2021, at 20–30ºC; Experiment II during Sep-Dec, 2021, at 13–22ºC; and Experiment III during Apr-Jun, 2022 at 8–18ºC. The results were compared and analyzed for any apparent seasonal differences. Stipe thinning began in the central region, as demonstrated by decreasing stipe weight, at a rate of 1.59% day− 1 (Expt. I), 1.59% day− 1 (Expt. II) and 0.13% day− 1 (Expt. III). Carbon content was similar whatever the season and almost constant. Nitrogen content was 50% higher in blades than in stipes. It is concluded that E. bicyclis stipes contribute to the coastal ecosystem by providing a long-lasting carbon sink. Accelerated decomposition of kelp stipes with increasing temperature suggests that global warming may reduce their value as an important coastal carbon sink.
Machine learning to predict adverse drug reaction or event based on electronic health records: a systematic review and meta-analysis
Authors: Hu Qiaozhi , Li Xiaoqi , Zou dan , xu ting , he zhiyao 
Published: March 2024

Abstract
Introduction
Machine learning (ML) for adverse drug reaction or event (ADR/ADE) prediction is emerging as the promising method for improving medical quality. We aimed to conduct a systematic review to comprehensively summarize ML prediction for ADR/ADE based on electronic health record (EHR).
Materials and methods
We systematically searched the PubMed, Web of Science, Embase, and IEEE Xplore databases from database inception to 21 Nov. 2023, to identify eligible studies. Any study that developed ML model to predict multiple ADR/ADE based on EHR was included in the final review. The pooled sensitivity, specificity and their 95% CI were calculated. Binary accuracy data were extracted for meta-analysis to derive area under the curve (AUC).
Results
5704 studies were identified, of which 10 studies met the inclusion criteria. Among the 20 ML methods reported in the including studies, Random Forest (RF) was reported the most (n=9), followed by Adaboost (n=4), eXtreme Gradient Boosting (n=3) and support vector machine (n=3). The mean AUC for ML prediction was 75.71% (26.00-94.57). RF combined with resampling based approaches might get high AUC, the mean was 82.92% (94.48-94.57). The length of stay, number of drugs, admission type, age, and high-risk drug used, such as antiviral agents, rifamycin, were the common risk factors for ADR/ADE prediction. The pooled estimated AUC of summary receiver operator characteristics was 72.00% (68.00-75.00).
Conclusions
Acceptable prediction performance of ADR/ADE with ML algorithmwas highlighted. More rigorous reporting standards and the new ML methods that take into account the unique challenges of ML research could improve future studies and help the application of ML models in clinical practice.
System Implementation of Emotion Recognition From Speech
Authors: khali sonia , Lee Chung 
Published: March 2024

Abstract
Emotional states can be expressed in facial expressions, speech, or body language. This study aims to create an effective system that can recognize emotional states from speech. The study proposes a methodology framework that uses acoustic features to recognize emotions. Initially, various methods for extracting features from speech are examined, and extensive statistical values are derived from the feature data. To recognize emotions from different speakers, a method to standardize the statistical features is presented. Normalization is proven to be necessary for building a high-performance system. Using normalized values, a score is calculated for each speech utterance, and the feature patterns for different emotions such as Anger, Boredom, Fear, Sadness, Happiness, and Neutral are examined. The study suggests that pitch, first formant, and speaking rate are the best features to distinguish emotions such as Anger, Fear, Boredom, Happiness, and Sadness. The study also shows that Support Vector Machine (SVM) can yield satisfactory performance in recognizing emotions. The system has achieved a high level of accuracy in detecting emotions such as Fear, Boredom, and Sadness. However, the method used in this study is not effective in recognizing emotions of Anger and Happiness.
Assessing the impact of land use and land cover (LULC) changes on the surface runoff downstream of an ungauged Bontanga watershed in Northern Ghana
Authors: Mwanga Eliafie , Shaibu Abdul-Ganiyu , Issaka Zakaria 
Published: March 2024

Abstract

Anthropogenic activities exacerbated by population growth, demanding land for food production and settlements, have led degradation of the Bontanga watershed. The aim of this study was to assess the impact of land use and land cover (LULC) change on the surface runoff in the Bontanga watershed from 1997 to 2022. LULC change maps for the years 1997, 2002, 2013, and 2022 were generated from Landsat images using ArcGIS, achieving overall accuracies of 92, 91.89, 95.27, and 83.64%, respectively. Surface runoff was estimated using the SCS–CN model. Correlation analysis was employed to identify predominant LULC change classes that impact surface runoff. The agricultural land and built-up area increased by 20.81% and 27.20% causing an increase in the surface runoff by 13.92 and 14.49% from 1997 to 2022. Due to anthropogenic activities, dense forest, grassland, mixed forest and shrub land, mixed shrub and grassland decreased by 20.31, 29.97, 22.51, and 25.58% causing an increase in surface runoff by 14.98, 14.06, 15.78, and 15.05%, respectively. Correlation analysis showed that changes in surface runoff were positively correlated with agricultural land, and mixed forest and shrub and negatively correlated with mixed shrub and grassland, and grassland.
Atopic Dermatitis and Abrocitinib: Unraveling the Therapeutic Potential
Authors: Memon Ayesha Abdul Qadir , Nisa Habibun , Osama Muhammad , Wei Calvin R. 
Published: March 2024

Abstract:
Atopic dermatitis (AD) is a chronic immune-mediated skin condition seriously affecting both children and adults and impacting their quality of life. This complex condition involves
genetic predisposition, immune system impairment, and environmental factors. The Janus kinase
signal transducer and activator of transcription (JAK-STAT) pathway plays a key role in AD
pathogenesis and progression. Abrocitinib presents a hopeful avenue for managing moderate to
severe AD, offering significant symptom relief and potential long-term benefits. Its targeted approach to modulating the JAK-STAT pathway holds promise for improved AD management.
This comprehensive review explores AD pathogenesis, the chemistry and clinical pharmacology
of Abrocitinib, and its safety and efficacy in various trials.
effect of celery (Apium graveolens l) ethanol extract on the prevention of gastric ulcers in rats
Authors: Sartika Lestari Ismail Dina Dewi , Kristianto Heri , Sandra Novita Yunianto  , Setyoadi Setyoadi 
Published: March 2024

Background: Gastric ulcer is an excoriation area of the stomach caused by the destruction of mucosal defense against the predominant factors. One of the efforts that should be made to reduce the incidence of gastric ulcers is a precautionary measure to use ethanol extract of celery (Apium graveolens L). Celery contains phenolic compounds, such as apigenin which acts as an antioxidant. Antioxidant has the potential as an agent of gastric mucosal protection against cell damage caused by excessive activation of free radicals (ROS). Objectives: This study aimed to determine the effect of celery ethanol extract in preventing gastric ulcers through a reduction of ulcer lesion length. Method: Research method Post-test Only Randomized Controlled Group Design conducted on Wistar strain rats. Experimental animals were divided into 5 groups: healthy, normal wound with induction indomethacin, and celery ethanol extract administered orally at a dose of 200 mg/kg, 300, mg/kg, and 400 mg/kg. Observations were made on the length of gastric ulcer lesions. The length of the gastric ulcer was measured using a vernier caliper and statistically analyzed by the One-way ANOVA test. Result: The result showed that the ethanol extract of celery at 300mg/kgBB was the best dose in preventing the formation of gastric ulcer by decreasing the length of the gastric ulcer. Conclusion: Based on these results, the researcher suggests comparing other various parameters regarding the effect of celery ethanol extract for the prevention of gastric ulcers.
Spiritual emotional freedom technique and level anxiety among people with pre-percutaneous coronary intervention
Authors: Dewi Inggriane Puspita , Izzaniar Purwanti  , Perla Yualita  
Published: March 2024

Introductions: Percutaneous Coronary Intervention is a low-risk diagnostic procedure, but many patients experience a high level of anxiety. Objectives: The purpose of the study was to determine the effect of SEFT on the anxiety level among people with Pre- Percutaneous Coronary Intervention. Methods: The research design used a quasi-experiment with a pretest-posttest design with a control group design. The number of samples used G-Power with nonprobability sampling was as many as 18 people in each group (a total of 36 people). The inclusion criteria are elective inpatients, patients diagnosed with CAD who have anxiety and are able to communicate, patients indicated as primary care, and patients with complications and panic are excluded, SEFT consists of set-up, tune-in, and tapping given one hour before cardiac catheterization for 15–25 minutes with two repetitions. Questionnaires for measuring anxiety levels before and after therapy using the Hamilton Scale for Anxiety (HARS) with validity (r count 0.57–0.97) and reliability (0.93–0.97). The analysis used Mann-Whitney. Results: The short version of SEFT in the control group (p-value 0.001) and the long version of SEFT in the intervention group (p-value <0.001) were proven to have an effect on reducing anxiety scores. there was no difference in the mean anxiety scores between the groups given the long version and the short version of the SEFT intervention (p-value 0,053). Conclusion: The conclusion of the study showed the effect of SEFT therapy on the anxiety of cardiac pre-catheterization patients. SEFT can be a complementary nursing therapy to reduce anxiety.
THE STUDENTS' DIFFICULTIES IN WRITING DESCRIPTIVE TEXT AT THE TENTH-GRADE STUDENT OF SMK N 4 JAMBI IN ACADEMIC YEARS 2022/2023
Authors: Adla Sheyla Halimatul 
Published: March 2024

The purpose of this research is to find out students' difficulties in writing descriptive text. The problem of this research is students' difficulties in generic structure, language features, lack of vocabulary and arranging sentences in writing descriptive text. The objective of this research is to identify the students' difficulties in writing descriptive text. The research was conducted at SMK N 4 Jambi in the academic year 2022/2023. The population of this research is tenth-grade student of fashion class IV. The sample is all of the fashion class IV at the tenth grade and the total number of students is 33 female students. The type of research is qualitative descriptive. The data were obtained by using an online questionnaire by using google forms. Overall, the result of this research is 51% of students have difficulties with language features. While, 57% of students have difficulties in generic structure, which is the same as those who have limited vocabulary in writing descriptive text. Moreover, the biggest percentages are the majority of students have difficulties in arranging sentences to be paragraphs.
Keywords; students' difficulties, writing descriptive text