bluuebunny/crossref_metadata_2025_split huggingface dataset:
High standard uptake value of the primary lesion of hepatocellular carcinoma correlates with early recurrence after curative resection
Authors: Kato Kazuya , Noda Takehiro , Kobayashi Shogo , Yamanaka Chihiro , Sasaki Kazuki , Iwagami Yoshifumi , Yamada Daisaku , Tomimaru Yoshito , Takahashi Hidenori , Asaoka Tadafumi , Shimizu Junzo , Doki Yuichiro , Eguchi Hidetoshi 
Published: April 2024

Abstract

Background
Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is useful for detecting the presence of distant metastases in many types of cancer, including hepatocellular carcinoma (HCC). However, the clinical significance of the standard uptake value (SUV) in primary HCC lesions is unclear.
Aim
We investigated the relationship between the SUV, clinicopathological factors, and prognosis in HCC.
Methods
The retrospective analysis included 86 patients with HCC who underwent FDG-PET/CT prior to liver resection. The distribution of SUV was compared in three groups: no recurrence after surgery, recurrence within 2 years, and recurrence after 2 years. The optimal cut-off SUV were determined based on receiver operating characteristic curve analysis to detect the recurrence within 2 years. All patients were divided into two groups based on the cut-off: low and high SUV. Cox univariate and multivariate analyses were performed for disease-free survival.
Results
The SUV was significantly higher in patients with recurrence within 2 years. The optimal cut-off SUV was 5.0. The patients in the high SUV group had significantly higher des-γ-carboxy prothrombin, poorer differentiation, and larger tumor diameter than the low SUV group, and presented with pathologically positive intrahepatic metastases. Moreover, high SUV was a significant and independent prognostic factor. In a subgroup analysis, high SUV had a significantly lower 2-year disease-free survival rate than the low SUV group in tumors ≤ 3.5 cm.
Conclusions
High SUV (≥ 5) on FDG-PET/CT of the primary HCC lesion, especially tumors ≤ 3.5 cm, correlates with early recurrence after curative resection and is an independent prognostic factor.
The effect of Entamoeba histolytica Lectin Antigen and MicroRNA-643 on the development of microsatellite instability (MSI) in Colorectal Adenocarcinoma
Authors: Haghighi Leila , Dalimi Abdolhossein , Pirestani Majid , Ghaffarifar Fatemeh 
Published: April 2024

Abstract
Globally, Entamoeba histolytica remains a leading cause of death. The impact of protozoa as environmental factors in microsatellite instability (MSI) remains largely unexplored, as are miRNAs as potential biomarkers for amoeba and in the context of colorectal disease. In this study, we investigated the relationship between the antigenic structure of the Eh-lectin and the altered expression of miRNA-643 and XIAP, a gene involved in apoptosis inhibition. The study aimed to detect E. histolytica, miRNA-643, XIAP, and MSI in 150 colorectal cancer biopsy samples. To achieve this, a multi-faceted approach employing immunohistochemistry (IHC), Multiplex PCR, RT-qPCR, and Real-Time PCR were utilized. For enhanced MSI diagnosis precision, PCR-Multiplex was performed concurrently with IHC. Among the 150 colorectal cancer biopsy samples analyzed, 39 (28 MSI-H and 11 MSI-L) exhibited microsatellite instability (MSI), while the remaining 111 were MSI-negative. Notably, co-occurrence of MSI and E. histolytica antigen was observed in 11 samples. These samples (positive for both MSI and E. histolytica antigen) showed an increased expression of miRNA-643, contrasting with XIAP expression. The concurrence of microsatellite instability (MSI) with E. histolytica antigen positivity and elevated miRNA-643 expression, contrasted with diminished XIAP inhibitor gene levels, in colorectal adenocarcinoma biopsy samples, strongly supports the hypothesis that this protozoan parasite plays a role in MSI development, through its potential involvement in apoptosis.
Evaluating the Influence of Adam and Ada-delta Optimizers on Varied Qubit Configurations in QLSTM Models
Authors: Namdeo Sachin , Nene Manisha J. 
Published: April 2024

Abstract

Quantum Machine Learning (QML) holds the promise of making significant changes to how Artificial Intelligence (AI) functions. A notable breakthrough in this field is the development of Quantum Long Short- Term Memory (QLSTM) networks, which exhibit faster learning compared to standard Long Short-Term Memory (LSTM) networks. QLSTM builds upon classical LSTM networks but incorporates principles of quantum computation, allowing it to explore superposition and entanglement for parallel information processing. By using quantum bits (qubits), QLSTM potentially offers advantages for specific machine learning tasks. Despite its potential, QLSTM remains a relatively unexplored area within QML, particularly regarding its dependency on the number of qubits and the impact of different optimizers on its performance. This study aims to reveal valuable insights to enhance QLSTM and explore its potential applications in AI. The study focuses on two main aspects. Firstly, exploring how the Adam and Ada-delta optimization methods improve QLSTM models, playing a role in refining the performance of the quantum model. Secondly, the study delves into the consequences of using varying numbers of qubits in the QLSTM model. Understanding how the quantity of qubits influences performance is essential for optimizing the network's efficiency. By addressing these aspects, the study seeks to contribute to advancing QLSTM and offering valuable knowledge for its potential applications in the AI field. The findings may suggest exciting opportunities for future research on QLSTM models, prompting exploration into optimization strategies, regularization techniques, and quantum data augmentation. Additionally, the study emphasizes the importance of leveraging ensemble learning and validating applicability in real-world quantum computing scenarios. These efforts are crucial for advancing understanding and maximizing potential in the continually evolving landscape of quantum computing applications.
Causal association between body mass index and risk of colon polyp: A Mendelian randomization study
Authors: Ning Xin-Jie , Li Jian-Feng , Guo Hui-Long , Chen Jing-Yao 
Published: April 2024

Abstract
Purpose
The relationship between obesity and colorectal polyps remain inconclusive .This study aimed to examine whether body mass index (BMI) is causally associated with colon polyp.
Methods
A two‐sample Mendelian randomization (MR) analysis using the inverse variance weighted (IVW), weighted median and MR‐Egger regression methods was performed. We used the publicly available summary statistics data sets of genomewide association studies (GWAS) meta‐analyses for BMI in individuals of European descent (n = 322 154; GIANT consortium) as the exposure and a GWAS for colon polyp included in the UK Biobank (total n = 463,010; case = 4,779, control = 458,231) as the outcome.
Results
We selected 76 single nucleotide polymorphisms at genome‐wide significance from GWASs on BMI as the instrumental variables. The IVW method showed evidence to support a causal association between BMI and colon polyp beta =0.002, SE =0.001, P = 0.012). MR‐Egger regression revealed that directional pleiotropy was unlikely to be biasing the result (intercept = -9.3e-06；P =0.889), but it showed no causal association between BMI and colon polyp (beta = 0.002， SE =0.002, P = 0.09). However, the weighted median approach yielded evidence of a causal association between BMI and colon polyp (beta = 0.001, SE =0.001, P = 0.01). Cochran's Q test and the funnel plot indicated no evidence of
heterogeneity and asymmetry, indicating no directional pleiotropy.
Conclusion
The results of MR analysis support that BMI may be causally associated with an increased risk of colon polyp.
First records of testate amoebae from the town of Ugolnye Kopi, Chukotka (Russian Arctic)
Authors: Sysoev Vlad V. , Neplyukhina Alisa A. , Petrovsky Andrey B. 
Published: April 2024

Abstract

Testate amoebae are a useful group of species for biogeographic research. Recent knowledge of the distribution of testate amoebae in the Arctic is incomplete because of large geographic gaps in species distribution data. In this study, we present the first report of testate amoebae from the eastern part of Chukotka in the Russian Arctic, which may at least partially bridge the gap between Alaska and the studied regions of the Russian Arctic. Testate amoebae were collected from 11 waterbodies in the vicinity of the town of Ugolnye Kopi, which is located on the coast of Anadyr Bay in the Bering Sea. Testate amoebae were abundant and active in the studied water bodies, even in the extreme physical environment of Chukotka. The genus and species structure of testate amoebae have been described. We found clear differences in the species structure of the assemblages inhabiting the studied water bodies. Our results showed that most of the testate amoeba assemblages in this part of Chukotka were dominated by Centropyxis pontigulasiformis, which is a typical Arctic species, assemblages found in small water bodies show more affinity to those from Spitzbergen, and the assemblage dominated by Cucurbitella mespiliformis was not previously reported in the Arctic. These results highlight the limited knowledge of the abundance and diversity of testate amoebae over large areas of the globe.
An extended energy analysis of managed forestry systems: Accounting for foregone biomass as an indicator of ecosystem impact
Authors: Dunlap Josh , Schramski John R. 
Published: April 2024

Abstract

Conventional energy analyses of forestry systems capture only human inputs and harvests, neglecting impacts to forest biomass stocks resulting from intensive management. This gap is addressed by extending the boundaries of forestry operations to the whole forest ecosystem. These new boundaries allow for the quantification of cumulative foregone biomass (ΔBc, the difference between accumulated potential and existing forest biomass stocks over time) under differing management scenarios to supplement the interpretation of conventional energy metrics such as net energy (NE) and the ratio of energy return to energy invested (EROI). Like existing models in the literature, our results confirm that less intensive management approaches achieve higher EROI values due to lower inputs. However, more significantly, magnitudes of ΔBc remain 1-2 orders of magnitude larger than NE over 100 years regardless of management scenario, and thus highlight an imbalance between the industrial and ecological energy dimensions of managed forests. This extended energy model begins to illustrate the overlooked role of ecological energy storage in forest management and offers insights to identify and design more sustainable management practices that can balance energy efficiency while minimizing resultant ecosystem impacts.
Impact of external obstructions and dirt accumulation on sustainable daylight performance through intelligent parametric optimization for open-plan offices.
Authors: Thakur Rohit , Sharma Aniket 
Published: April 2024

Abstract

Daylight is frequently viewed as a valuable resource for increasing energy efficiency and improving indoor visual comfort. The quality and quantity of natural light entering a building depends on both internal and external factors. People require adequate daylight at their workstations, particularly in open-plan settings, in order to function well. The development of dirt or particles on the windows, such as moss, dust, water, and sand, and shading effects due to nearby obstructions prevents light energy from accessing the created envelope. The open-plan office in Hamirpur district of Himachal Pradesh, India was chosen for this study to undertake an experiment with varied amounts of dirt accumulation and nearby shading effect. A thorough survey of the literature is also performed in order to uncover research methodologies applied to optimization of daylight. This research shows how parametric modeling may be used to increase the daylight performance of an open-plan office in a humid subtropical environment (Cwa). The foundation model of an open-plan office was used to optimize daylight. To conduct the study, a grasshopper script is created using the primary plug-ins Honeybee, Ladybug, Octopus, and TT Toolbox. The statistical mean bias error (MBE) is used to validate the base model. Using sensitivity analysis, the results are further evaluated to discover interrelationships.
Propose A Simple General Love Model in Biological Systems
Authors: Hu Xiaolan 
Published: April 2024

Abstract

Love is a topic of immense interest with unique ties to human existence, with almost no solid scientific mechanism to date beyond the neurological systems. Here, I propose that the basic unit of love may exist as a physical circular system with frequencies. Simple models built on this hypothesis can be employed to simulate cell and extended to understand cancer initiation. Additionally, this simple model could help us discover novel signals in empirical biological data that are currently ignored in conventional analyses. Further development of the framework may have broad applications in multiple disciplines.
Morphologically driven sedimentation patterns on a coral reef
Authors: Sartori Greta , Boles Elisabeth L , Monismith Stephen G , Dunbar Robert B , Mumby Peter J , Khrizman Alexandra , Tatebe Lyvonsky , Capozzi Rossella 
Published: April 2024

Abstract
Coral reef sediment research focused on quantifying production sources, suspended sediment, and trapping or accumulation rates, overlooking the role of hydrodynamics and reef morphology in determining these. We used an interdisciplinary approach, focusing on the links between physical features and processes and hypothesized how they affect reef recovery. Typhoon Bopha hit Ngederrak Reef (Palau) in 2012, significantly reducing coral cover. The reef is characterized by spur and grooves (SAGs) and bordered by two tidal channels, but SAGs are not present in its northernmost part, near one of these channels. The reef has recovered in the SAG area, but its recovery was slower in the north. Flow measurements and sediment samples taken in SAG and non-SAG areas were used to calculate the threshold for sediment movement due to mean flows and wave orbital velocities. Sediment on SAGs was mainly suspended by waves, but the direction of net transport was determined by the mean flow. The threshold for sediment movement due to mean flow was reached 80–100% of the time on spurs, in grooves it was reached 60% and 33% of the times during flooding and ebbing tides respectively. This tidal asymmetry suggests that sediment was removed from spurs and transported seaward in grooves to be stored at depth. The steeper slope in grooves (8%) relative to the non-SAG area (4%), favors rubble accumulation and stabilization. This information can help predict localized sediment impacts as well as describing the role of the widely distributed SAG morphology in promoting coral reef recovery.
Co-administration of atorvastatin and piperine impairs fertility potential in male Wistar rats through disruption of cholesterol homeostasis and testosterone production
Authors: Ghosh Sanjib , Sarkar Sweata , Mistry Jayanta , Biswas Maharaj 
Published: April 2024

Abstract
Background
Atorvastatin is administered to treat hyperlipidemia. The fruit of the black pepper plant contains the alkaloid piperine. Both atorvastatin and piperine are known to have hypolipidemic effects. The goal of the current investigation was to assess the effects of atorvastatin and piperine on reproductive potential in male Wistar rats. For this study, twenty rats were obtained and placed into four groups, each with five rats. Group I served as a control, group II animals are treated with atorvastatin (8 mg/kg BW), group III animals received piperine (10 mg/kg BW) and group IV animals were co-administered with piperine (10 mg/kg BW) and atorvastatin (8 mg/kg BW). All treatments were done by using oral gavage for consecutive 28 days and thereafter assessed for lipid profile, H-E staining, sperm parameter analysis, testosterone level detection using ELISA.
Results
The results showed that co-administration of atorvastatin and piperine (p < 0.05) significantly reduced weight of reproductive organs, changed histoarchitectural patterns of seminiferous tubules, epididymis, seminal vesicle. Serum and testicular cholesterol and testosterone levels of atorvastatin and piperine co-treated (p < 0.05) groups were found to decrease. Sperm count, motility and viability were decreased significantly in atorvastatin and piperine co-treated animals.
Conclusion
Results of this study revealed that consumption of piperine (active ingredient of black pepper) along with atorvastatin (lipid-lowering drug) have deleterious effects on reproductive potential of male rat.
Mineral precipitation sequence from multi-stage fluids released by eclogite during high-pressure metamorphism
Authors: Gong Ting-Nan , Du Jin-Xue , Zhang Li-Fei , Chen Zhen-Yu , Zhang Ze-Ming , Wang Wei-(RZ) , Qu Yuan-Ru 
Published: April 2024

Abstract
Arc magmas above subduction zones hold abundant fluid-mobile elements attributed to fluids released from the dehydrating subducted oceanic crust. However, the quantity of trace elements in the fluids and their evolution with the metamorphic processes during subduction and exhumation are still unclear. The precipitation sequence of vein minerals preserves the nature of multi-stage high-pressure (HP) metamorphic fluids and the fingerprint of mass exchange in deep subduction zones. In this contribution, we conducted detailed petrological studies and phase equilibria modeling on a unique HP omphacite-rich vein and its host eclogite from the Chinese southwestern Tianshan. The host eclogite consists mainly of garnet, omphacite, epidote, glaucophane, phengite, quartz, and rutile. Garnet in the eclogite records prograde subduction and early exhumation characterized by decompression heating at P-T conditions of ∼2.4–2.6 GPa and 460–540 °C. The embedded omphacite-rich vein has similar mineral assemblage to the host eclogite. Garnet grains in this vein are predominantly distributed along or intersect the vein wall, which records similar eclogite-facies metamorphic conditions to the host eclogite. Omphacite is dominant in the vein, while epidote and glaucophane occur interstitially. Phase equilibria modeling reveals sequential growth of garnet-dominated, omphacite-dominated, and epidote-dominated assemblages from fluids originating from the breakdown of different hydrous minerals. These lines of evidence suggest that the formation of multi-stage HP fluids are a continuous long-term process with spontaneous short-distance transport and sequential mineral precipitation. Calculated fluid compositions demonstrate that the fluids released by lawsonite breakdown during exhumation have great potential to modify the trace element systematics of arc magmas. Our findings reveal the nature and evolution of multi-stage HP metamorphic fluids from internal sources during subduction and exhumation of oceanic crust, providing valuable insights into the chemical compositions of arc magmas.
Fate and behavior of microplastics in wastewater, accumulation in organisms and effects
Authors: Egea-Corbacho Agata , Franco Ana Amelia , Martín-García Ana Pilar , Quiroga José María , Coello María Dolores 
Published: April 2024

Abstract
Studies on how microplastics (MPs) behave in wastewater treatment plants (WWTPs) are increasing day by day. Although conventional WWTPs can efficiently remove MPs (64–99%), when considering the daily discharge rate, this percentage would not be sufficient. The total amount of MPs would still be discharged daily into the environment; therefore, the final effluent can act as one of the main routes of entry of MPs into aquatic environments. This chapter reviews the behavior of MPs in the different WWTP units, as well as their accumulation in the sludge. Subsequently, a discussion on how the MPs from the WWTP can reach the receiving media, such as aquatic or terrestrial media (water line and sludge line), to finally discuss how the fauna is affected by the entry of the MPs into the environment. These MPs can be ingested by aquatic life forms, leading to their bioaccumulation and biomagnification along the food chain, and causing negative effects on tissues, organs, and metabolism. MPs can also act as transport vehicles for other emerging pollutants such as pharmaceuticals and pesticides, increasing their hazardousness.
Os “profissionais” de educação de adultos e a importância dos contextos de trabalho para o seu processo de aprendizagem e construção de saber: Um processo suficiente?
Authors: Loureiro Armando Paulo Ferreira 
Published: April 2024

Não existe, de forma generalizada, a exigência de se ter uma formação académica especializada para se poder trabalhar na educação de adultos. Partindo desta realidade, há uma questão à qual temos procurado responder com base em várias investigações concretizadas ao longo dos anos: como é que aqueles que desenvolvem as suas atividades na educação de adultos aprendem e constroem os saberes necessários para efetuarem as suas funções? Neste artigo reflete-se sobre o relevo que os contextos de trabalho podem ter nesse processo. Os resultados a que temos chegado apontam quatro grandes dimensões implicadas em tal processo, tendo plena consciência que ele é mais vasto: a formação profissional contínua; a construção e reconstrução da aprendizagem e do saber; a transferência das aprendizagens e do saber, sua circulação e coletivização; e a dimensão temporal da aprendizagem e do saber. Mas, os resultados mostram-nos também que este património construído a espaços é frequentemente destruído, porque não há uma aposta política contínua na educação de adultos. Desta forma é difícil defender que há profissionais da educação de adultos, é difícil falar da existência generalizada de um dos que seria um dos seus traços identitários mais marcantes: um conhecimento, um saber específico que os distinga. Assim, a identidade profissional dos que trabalham na educação de adultos continua a ser ténue e o processo de profissionalização de difícil realização.