bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reasonable adjustments to application of the Medication Safety Standard for adult patients living with intellectual disability in Australian hospital settings
Authors: Wallace Robyn Anne 
Published: March 2024

AbstractPurpose of reviewAdults living with intellectual disability experience higher rates of preventable adverse medication events across the medicine pathway compared to their peers without disability.Source of informationThe Medication Safety Standard, developed by the Australian Commission on Safety and Quality in Health Care, describes systems and strategies to ensure that clinicians and health organisations safely prescribe, dispense, administer appropriate medications to informed patients, and monitor their use.Key findingsOptimal application of the Medication Safety Standard for this population requires the development of reasonable adjustments to its action which take into account the barriers to safe medication management experienced by them in hospital settings. Design of such reasonable adjustments is influenced by consideration of the experiences of medicine management within with people living with intellectual disability, with intellectual disability, the roles of disability supports, and the disability‐health sector interface in relation to medication management.ConclusionThis review describes the formulation of a range of practice point reasonable adjustments to the usual clinical processes, content, knowledge, and organisation required in application of the Medication Safety Standard for adult patients living with intellectual disability.
Higher satisfaction and function scores in restricted kinematic alignment versus mechanical alignment with medial pivot design total knee arthroplasty: A prospective randomised controlled trial
Authors: Ettinger Max , Tuecking Lare‐Rene , Savov Peter , Windhagen Henning 
Published: March 2024

AbstractPurposeRestricted kinematic alignment (rKA) in total knee arthroplasty (TKA) and medial pivot (MP) knee designs already showed superior outcomes in independent comparative studies. The objective of this study was to assess whether rKA with MP TKA provides better clinical and functional outcomes compared to mechanical alignment (MA) with MP TKA.MethodsThis is a randomised, parallel two group study involving a total of 98 patients with end‐stage knee osteoarthritis. Patients were randomly allocated to either rKA or MA TKA procedures conducted with a MP prothesis using patient‐specific instruments between 2017 and 2020. Final follow‐up was at 2 years postoperatively. Demographic data and clinical and functional scores (Oxford knee score, knee society score [KSS], Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC], forgotten joint score [FJS]) were collected and compared preoperative, 1 year postoperative and 2 years postoperative. Coronal plane alignment of the knee and functional knee phenotype classification were recorded.ResultsA total of 47 patients (rKA) and 51 patients (MA) were included in final analysis. Superior joint awareness scores (FJS) were found at 1 year postoperative for rKA (62.2 vs. 52.4, p = 0.04). KSS subscores (expectation score, satisfaction score) improved with rKA with significant differences at both 1 and 2 years postoperatively. Major differences between rKA and MA were found in subgroup analysis of varus and neutral CPAK phenotypes. Both 1 year and 2 years postoperatively, FJS was significantly better in KA compared with MA in varus CPAK phenotypes (63.1 vs. 44.9, p = 0.03; 71.1 vs. 46.0, p = 0.005). Further clinical and functional scores showed improvement in the varus CPAK phenotypes with predominantly significant improvement in the expectation and satisfaction KSS subscores. No significant differences were found in the comparison of rKA and MA in neutral CPAK phenotypes.ConclusionThe rKA of MP TKA design shows superior patient satisfaction and self‐reported function when compared to MA MP TKA. Furthermore, rKA MP TKA shows superior joint awareness at early postoperative stage. The most important clinical relevance of this study is the clear superiority of rKA in varus phenotypes.Level of EvidenceLevel II.
From clinical competence to human connection: A reflective journey to patient‐centred care
Authors: Gringras David 
Published: March 2024

AbstractIntroductionThis reflective essay explores a medical student's evolving understanding of the relative roles of technical and interpersonal skills in shaping the patient experience.MethodsThe author's personal reflections on the relative roles of technical and interpersonal skills are supplemented with discussion of relevant literature.Results and DiscussionInitially focused on the technical aspects of medicine, the author's perspective shifts upon entering clinical practice. The essay begins by emphasising the importance of interpersonal skills in patient satisfaction, drawing on personal experiences from general practice and supporting literature. However, a pivotal experience on a respiratory ward reveals the profound impact of interpersonal skills on both patient satisfaction and clinical outcomes. With further reflection incorporating relevant literature, it becomes clear that this case in‐fact underscores the interplay between technical knowledge and interpersonal skills.ConclusionThe reflective exploration concludes with the insight that these skillsets are not independent but interdependent and synergistic. The essay thus advocates for an integrated approach (combining technical expertise with strong interpersonal communication) to foster patient partnerships and enhance the overall patient experience.
The RNA‐binding protein sorbin and SH3 domain‐containing 2 are transcriptionally regulated by specificity protein 1 and function as tumor suppressors in bladder cancer by stabilizing tissue factor pathway inhibitor
Authors: Wang Beibei , Fan Xin , Wang Lingang , Wei Xiaosong 
Published: March 2024

AbstractSorbin and SH3 domain‐containing 2 (SORBS2) is an RNA‐binding protein and has been implicated in the development of some cancers. However, its role in bladder cancer (BC) is yet to be established. The expression of SORBS2 in BC tissues was determined from the Gene Expression Omnibus and Gene Expression Profiling Interactive Analysis databases and collected paired tumor/normal samples. The effects of SORBS2 on BC cells were detected by CCK‐8, colony formation, Transwell, dual‐luciferase, RNA immunoprecipitation, chromatin immunoprecipitation, and DNA pull‐down assays. In vivo, BC cell growth and metastasis were studied by a xenograft subcutaneous model and a tail‐vein metastasis model. The results showed that SORBS2 expression was significantly decreased in BC tissues and cells. SORBS2 overexpression inhibited cell proliferation, migration, invasion, and epithelial–mesenchymal transition in vitro and tumor growth and metastasis in vivo, while silencing SORBS2 produced the opposite effect. Mechanistically, we found that SORBS2 enhanced the stability of tissue factor pathway inhibitor (TFPI) mRNA via direct binding to its 3′ UTR. Restoration of TFPI expression reversed SORBS2 knockdown‐induced malignant phenotypes of BC cells. In addition, SORBS2 expression was negatively regulated by the transcription factor specificity protein 1 (SP1). Conversely, SORBS2 can be transcriptionally regulated by SP1 and inhibit BC cell growth and metastasis via stabilization of TFPI mRNA, indicating SORBS2 may be a promising therapeutic target for BC.
Most recent advances and applications of extracellular vesicles in tackling neurological challenges
Authors: Kaur Mandeep , Fusco Salvatore , Van den Broek Bram , Aseervatham Jaya , Rostami Abdolmohamad , Iacovitti Lorraine , Grassi Claudio , Lukomska Barbara , Srivastava Amit K. 
Published: March 2024

AbstractOver the past few decades, there has been a notable increase in the global burden of central nervous system (CNS) diseases. Despite advances in technology and therapeutic options, neurological and neurodegenerative disorders persist as significant challenges in treatment and cure. Recently, there has been a remarkable surge of interest in extracellular vesicles (EVs) as pivotal mediators of intercellular communication. As carriers of molecular cargo, EVs demonstrate the ability to traverse the blood–brain barrier, enabling bidirectional communication. As a result, they have garnered attention as potential biomarkers and therapeutic agents, whether in their natural form or after being engineered for use in the CNS. This review article aims to provide a comprehensive introduction to EVs, encompassing various aspects such as their diverse isolation methods, characterization, handling, storage, and different routes for EV administration. Additionally, it underscores the recent advances in their potential applications in neurodegenerative disorder therapeutics. By exploring their unique capabilities, this study sheds light on the promising future of EVs in clinical research. It considers the inherent challenges and limitations of these emerging applications while incorporating the most recent updates in the field.
Scoring system related to retrograde percutaneous coronary intervention for coronary chronic total occlusion
Authors: Wen Song , Wang Jing , Huang Zehan , Huang Yuqing , Wang Feng , Zhang Bin 
Published: March 2024

AbstractThe retrograde approach is a principal procedure used in coronary chronic total occlusion percutaneous coronary intervention. However, the retrograde approach presents more challenges compared with the antegrade approach, as it is associated with a lower rate of success and a higher risk of complications. An accurate pre‐procedural evaluation of the complexity of a lesion could aid in the planning of the procedure, in estimating the procedure's duration, or in determining whether the patient should be referred to another center specializing in CTO‐PCI, as well as in a more precise evaluation of the risk‐benefit ratio. In recent years, multiple scoring systems have been created to forecast the success and efficiency of the retrograde procedure. However, each scoring system was developed independently, and comparative studies were lacking. This article provides a review of these scoring systems, offers an overview of the current state of the retrograde approach, and aims to stimulate further discussion on this topic.
Realization of nonreciprocal acoustic energy transfer using an asymmetric strong nonlinear vibroacoustic system
Authors: Jin Jiangming , Huang Jingxiao , Xiao Yuepeng 
Published: March 2024

AbstractIn this paper, an asymmetric vibroacoustic system that can passively realize nonreciprocal transmission of acoustic energy is reported. This experimental system consists of a waveguide, a strongly nonlinear membrane, and three acoustic cavities with different sizes. The theoretical modeling of the system is verified by experiments, and parametric analysis is also carried out. These intensive studies reveal the nonreciprocal transmission of acoustic energy in this prototype system. Under forward excitation, internal resonance between the two nonlinear normal modes of the vibroacoustic system occurs, and acoustic energy is irreversibly transferred from the waveguide to the nonlinear membrane. However, under backward excitation, there is no internal resonance in the system. Energy spectra and wavelet analysis are used to highlight the mechanism of nonreciprocal transfer of acoustic energy. Consequently, nearly unidirectional (preferential) transmission of acoustic energy transfer is shown by this system. The nonreciprocal acoustic energy transfer method illustrated in this paper provides a new way to design the odd acoustic element.
Prevalence and predictors of female sexual dysfunction among sexually active women in the diabetes prevention program outcomes study
Authors: Gupta Priyanka , Doherty Lindsay , Temprosa Marinella , Pop‐Busui Rodica , Gadde Kishore M. , Singh Prachi , Owora Arthur H. , Wessells Hunter , Sarma Aruna V. ,   for the Diabetes Prevention Program Research Group
Published: March 2024

AbstractObjectiveTo determine the burden and identify correlates of female sexual dysfunction (FSD) among women with prediabetes (PreD) and type 2 diabetes (T2D) enrolled in the Diabetes Prevention Program (DPP) Outcomes Study (DPPOS).MethodsThe DPPOS visit included the Female Sexual Function Index (FSFI) to determine sexual function. Of 1464 participants, 1320 (90%) completed the (FSFI) and 426 were sexually active. A backward selection multivariable logistic regression model estimated the odds of FSD for sociodemographic, clinical, and diabetes‐related covariates.ResultsOne hundred and eighty‐five (43%) had a score of ≤26.55 and met the criteria for FSD. After adjustment for DPP treatment and age, urinary incontinence (UI) (odds ratio [OR] = 1.91, 95% confidence interval [CI] = 1.15–3.17) and hysterectomy (OR = 1.89, 95% CI = 1.01–3.53) were associated with increased odds of FSD. Increased body mass index was protective for FSD (OR = 0.93 per kg/m2, 95% CI = 0.89–0.96). Michigan Neuropathy Screening Instrument‐based peripheral neuropathy (mean±SD scores 1.1±1.3 vs. 0.9±1.1, p < 0.0001) and Electrocardiogram (ECG)‐based autonomic dysfunction measures (mean ± SD heart rate levels 64.3 ± 6.8 vs. 65.6 ± 10.2, p = 0.008) were associated with FSD. There were no differences in diabetes rates between women who did (66.5%) and did not (66%) have (p = 0.7).ConclusionsFSD is prevalent in women with PreD and T2D. Our findings suggest that FSD is associated with neuropathic complications commonly observed in PreD and T2D.
Optimizing practices to prevent urinary tract infection after cystoscopy and urodynamics in women: A quality improvement study
Authors: Benseler Anouk , Tomlinson George , Lovatsis Danny , Alarab May , McDermott Colleen D. 
Published: March 2024

AbstractObjectiveThe objective of this study was to reduce the incidence of urinary tract infection (UTI) in women undergoing outpatient cystoscopy and/or urodynamic studies (UDS) at our centre by identifying and then altering modifiable risk factors through an analysis of incidence variability among physicians.MethodsThis was a quality improvement study involving adult women undergoing outpatient cystoscopy and/or UDS at an academic tertiary urogynecology practice. Prophylactic practices for cystoscopy/UDS were surveyed and division and physician‐specific UTI rates following cystoscopy/UDS were established. In consultation with key stakeholders, this delineated change concepts based on associations between prophylactic practices and UTI incidence, which were then implemented while monitoring counterbalance measures.ResultsTwo “Plan‐Do‐Study‐Act‐Cycles” were conducted whereby 212 and 210 women were recruited, respectively. Change concepts developed and implemented were: (1) to perform routine urine cultures at the time of these outpatient procedures, and (2) to withhold routine prophylactic antibiotics for outpatient cystoscopy/UDS, except in patients with signs of cystitis. There was no change in the incidence of early presenting UTI (9.0% vs. 9.2%, p = 0.680), but there were significantly fewer antibiotic‐related adverse events reported (8.5% vs. 1.5%, p = 0.001). There was no significant change in the total incidence of UTI rates between cycles (7.8% vs. 5.6%, p = 0.649).ConclusionsNo specific strategies to decrease the incidence of UTI following outpatient cystoscopy/UDS were identified, however, risk factor‐specific antibiotic prophylaxis, as opposed to universal antibiotic prophylaxis, did not increase UTI incidence.
Hamilton‐Jacobi‐Bellman equation based on fractional random impulses system
Authors: Guo Yu , Dai Zhenyi 
Published: March 2024

AbstractIn this talk, we consider the optimal control problem for fractional order random impulses differential equations (), and there is no corresponding Hamilton‐Jacobi‐Bellman (HJB) equation proposed for fractional order differential equations in existing literature. The lack of semi group properties in fractional order makes the original dynamic programming methods unable to directly handle fractional order problems. We have dealt with this problem by combining the properties of fractional order integrals. In solving this problem, we found that the order of the original system in HJB equation is at least 1. When the order is less than 1, our approach to fractional order ideas provides a possibility to solve the problem.
RETRACTED: Studies on improved stability and electrochemical activity of metal oxides/sulfides‐based polymer nanocomposites for energy storage applications
Authors: Xavier Joseph Raj 
Published: March 2024

AbstractPoly (3‐methylthiophene) (P3MT) was modified by nickel oxide (NiO) and nickel sulfide (NiS) nanoparticles to enhance its electrochemical performance. The surface influence, crystalline structure, and electrochemical performance of the P3MT/NiO/NiS material were characterized and compared with that of pristine P3MT. It is found that surface modification can improve the structural stability of P3MT without decreasing its available specific capacitance. The electrochemical properties of synthesized P3MT/NiO/NiS electrode were evaluated using cyclic voltammetry and alternating current impedance techniques in 3 M KOH electrolyte. Specific capacitances of 253, 764, 932, and 1434 F g−1 were obtained for P3MT, P3MT/NiO, P3MT/NiS, and P3MT/NiO/NiS, respectively at 5 A g−1. This improvement is attributed to the synergistic effect of Ni2+ ions in the P3MT/NiO/NiS electrode material. The P3MT/NiO/NiS electrode in KOH has average specific energy and specific power densities of 1032 Wh kg−1 and 6192 W/kg, respectively. Only 2% of the capacitance's initial value is lost after 10,000 cycles. The resulting P3MT/NiO/NiS nanocomposite had very stable and porous layered structures. This work demonstrates that P3MT/NiO/NiS nanomaterials exhibit good structural stability and electrochemical performance, and are good material for supercapacitor applications.Highlights
The P3MT/NiO/NiS nanocomposite is fabricated and characterized as supercapacitor electrode.
The incorporation of NiO/NiS in the poly (3‐methylthiophene) has improved the electrochemical performance.
The P3MT/NiO/NiS electrodes retained 98% of their specific capacitance after 10,000 cycles.
The P3MT/NiO/NiS nanocomposite electrode showed specific capacitance of 1434 F g−1 at 5 A g−1.
The stability of the nanocomposite was enhanced without altering its morphology and chemical structure.
High‐performance tetraphenylethene‐containing poly (p‐phenylene terephthalamide) paper with aggregation‐induced emission characteristics
Authors: Wu Bing , Gao Yufu , Zhang Wenlong , He Yaning 
Published: March 2024

AbstractIn the rapidly advancing era of intelligent technologies, the development of advanced materials characterized by high performance and functionality is considered a crucial aspect. A series of high‐performance functional polymers known as cis/trans‐tetraphenylethene‐containing poly (p‐phenylene terephthalamide) (cis/trans‐TPE‐PPTA), has been developed. These polymers exhibited typical aggregation‐induced emission (AIE) characteristics along with exceptional electrical and mechanical properties. It has been observed that addition ratios of cis/trans‐TPE‐2NH2 as the comonomer significantly influenced the properties of the cis/trans‐TPE‐PPTA paper. Specifically, when compared with pure poly (p‐phenylene terephthalamide) (PPTA), the homogeneous trans‐TPE‐PPTA paper at 10% trans‐TPE‐2NH2 addition ratio, fabricated using a hot‐pressing method, demonstrated significantly improved overall performance, including a substantial increase in tensile strength (97.4%) and dielectric strength (41.5%), as well as other favorable properties. This enhancement suggests promising prospects for numerous applications.
Clinical efficacy of montelukast sodium combination therapy for cough variant asthma in children: A meta‐analysis
Authors: Yang Shihai , He Xia , Zhang Rixia 
Published: March 2024

AbstractThis meta‐analysis aims to assess the clinical effectiveness of combination therapy with montelukast sodium for the treatment of cough variant asthma (CVA) in children, intending to provide clinical evidence and data to guide the selection of clinical therapy. A literature review was conducted using numerous databases, including China National Knowledge Infrastructure (CNKI), Wanfang database, Embase, PubMed, and Web of Science, from inception to December 2023. Trials meeting the criteria for the combined treatment of montelukast sodium for CVA in children were included. Stata 16.0 software was utilized for meta‐analysis. The combined treatment group received montelukast sodium in addition to the control group, while the control group received budesonide, fluticasone propionate, salmeterol‐fluticasone, or ketotifen alone. This investigation included 18 papers. All subjects were from the Chinese population. Compared to the control group, the combined treatment group demonstrated a higher effective rate (relative ratio [RR] = 1.23, 95% confidence interval [CI]: 1.18–1.29, p < .001), but no difference in the incidence of adverse reactions (RR = 0.65, 95% CI: 0.42–1.02, p = .060) after treatment. Moreover, the peak expiratory flow (PEF) (SMD = 1.69, 95% CI: 1.09–2.30, p < .001), forced vital capacity (FVC) (SMD = 1.67, 95% CI: 0.94–2.39, p < .001), forced expiratory volume in 1 s (FEV1) (SMD = 1.74, 95% CI: 1.09–2.40, p < .001), and FEV1/FVC (SMD = 1.84, 95% CI: 0.41–3.28, p = .012) were significantly higher in the combined treatment group than in the control group after treatment. Compared with the control group, the levels of tumor necrosis factor‐α (SMD = −2.38, 95% CI: −3.22 to −1.55, p < .001), IL‐4 (SMD = −2.65, 95% CI: −3.26 to −2.04, p < .001), and IgE (SMD = −2.98, 95% CI: −3.24 to −2.72, p < .001) were significantly lower in the combined treatment group after treatment. The combined use of montelukast sodium in the treatment of pediatric CVA in China is associated with a significant clinical effect, making it a reasonable therapeutic approach.
In utero smoking exposure induces changes to lung clearance index and modifies risk of wheeze in infants
Authors: De Queiroz Andrade Ediane , Sena Carla Rebeca Da Silva , de Gouveia Belinelo Patricia , Robinson Paul D. , Blaxland Anneliese , Sly Peter D. , Murphy Vanessa E. , Gibson Peter G. , Collison Adam M. , Mattes Joerg 
Published: March 2024

AbstractBackgroundFetal exposure to tobacco smoking throughout pregnancy is associated with wheezing in infancy. We investigated the influence of in utero smoking exposure on lung ventilation homogeneity and the relationship between lung ventilation inhomogeneity at 7 weeks of age and wheezing in the first year of life.MethodsMaternal smoking was defined as self‐reported smoking of tobacco or validated by exhaled (e)CO > 6 ppm. Lung function data from healthy infants (age 5–9 weeks) born to asthmatic mothers and parent‐reported respiratory questionnaire data aged 12 months were collected in the Breathing for Life Trial (BLT) birth cohort. Tidal breathing analysis and SF6‐based Multiple Breath Washout testing were performed in quiet sleep. Descriptive statistics and regression analysis were used to assess associations.ResultsData were collected on 423 participants. Infants born to women who self‐reported smoking during pregnancy (n = 42) had higher lung clearance index (LCI) than those born to nonsmoking mothers (7.90 vs. 7.64; p = .030). Adjusted regression analyzes revealed interactions between self‐reported smoking and LCI (RR: 1.98, 95% CI: 1.07–3.63, 0.028, for each unit increase in LCI) and between eCO > 6 ppm and LCI (RR: 2.25, 95% CI: 1.13–4.50, 0.022) for the risk of wheeze in the first year of life.ConclusionIn utero tobacco smoke exposure induces lung ventilation inhomogeneities. Furthermore, an interaction between smoke exposure and lung ventilation inhomogeneities increases the risk of having a wheeze in the first year of life.