bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and pathogenetic justification for the use of therapeutic plasma exchange in the complex of preoperative preparation of patients with non-small cell lung cancer complicated by the inflammatory process
Authors: Ushakova N. D. , Rozenko D. A. , Tikhonova S. N. , Kharagezov D. A. , Popova N. N. 
Published: March 2024

Purpose of the study. Determination of pathogenetic substantiation and indication criteria for the inclusion of extracorporeal detoxification methods in preoperative preparation of patients with non-small cell lung cancer (NSCLC) complicated by inflammation.Patients and methods. This study included the data on 222 patients with newly diagnosed stage I–IV NSCLC referred for elective surgical treatment to the Department of Thoracic Oncology, National Medical Centre for Oncology, in 2017–2019. Endogenous intoxication was evaluated in all patients depending on the leukogram results: leukocytic intoxication index (LII), body resistance index (BRI), reactive neutrophil response (RNR), and neutrophil-lymphocyte ratio (NLR). Indicators of the inflammatory response, i. e. interleukin 6 and procalcitonin, were also studied.Results. 36.5 % of NSCLC patients developed inflammation. That over 70 % of the NSCLC patients showed pronounced clinical and laboratory signs of endogenous intoxication and inhibited protective systems of homeostasis. Initial sub- or decompensated endotoxicosis together with reduced overall reactivity of the body poses a high risk of systemic inflammatory response to antitumor surgical treatment. This justifies the inclusion of extracorporeal detoxification into preoperative preparation of this category of patients as an active preoperative therapy.Conclusions. Simultaneous elevation of LII, RNR and NLR characterizing the presence of endotoxicosis in sub- and decompensation of endogenous intoxication by own physiological detoxification systems requires an active preoperative preparation with extracorporeal detoxification.
MicroRNA-34, microRNA-130, microRNA-148, microRNA-181, microRNA-194 and microRNA-605 expression in colon cancer tissue
Authors: Azovsky D. I. , Afanasyev S. G. , Avgustinovich A. V. , Spirina L. V. , Kovaleva I. V. , Zinnurova A. B. , Belova V. A. 
Published: March 2024

Purpose of the study. Determination of the expression of microRNA‑34, microRNA‑130, microRNA‑148, microRNA‑181, microRNA‑194 and microRNA‑605 in colon tumor tissue depending on the clinical and morphological features of the tumor and the effectiveness of treatment.Materials and methods. The study included 56 patients diagnosed with colorectal cancer aged 43 to 75 years with the average age of 54 years. Taking into account the local prevalence of the process patients received surgical or combined treatment, including neoadjuvant chemotherapy, in the clinics of the Cancer Research Institute, Tomsk NRMC. MicroRNA expression was determined by polymerase chain reaction (PCR) in real time.Results. The obtained information revealed the relation of microRNA‑130 to the tumor size. The development of regional metastases was associated with changes in microRNA‑130, microRNA‑194 and microRNA‑605. The level of histological organization of the tumor was associated with microRNA‑34, microRNA‑130, microRNA‑148, and the response to therapy – with microRNA‑130, microRNA‑148 and microRNA‑605. In addition, according to the study, the significance of microRNA‑130 was revealed, which is associated with tumor spread, histological differentiation and response to antitumor therapy.Conclusion. The features of expression of microRNA‑34, microRNA‑130, microRNA‑148, microRNA‑181, microRNA‑194 and microRNA‑605 associated with clinical and morphological features of colon tumors were revealed. Correlations between the studied indicators are noted, which probably determine the outcome and prognosis of the disease.
Characteristics of anesthetic and surgical tactics in treatment of a patient with a giant thyroid mass in a cancer center (clinical case)
Authors: Rozenko D. A. , Engibaryan M. A. , Kharagezov D. A. , Zhenilo M. V. , Popova N. N. , Bauzhadze M. V. , Marykov E. A. 
Published: March 2024

This paper describes an example of radical surgical treatment of a patient with a giant retrosternal goiter complicated by compression of the organs of the neck and mediastinum. Considering all the risks and possible complications, we should take into account the fact that enlarged thyroid (T) body with retrosternal location can cause displacement and stenosis of the trachea and esophagus, and dislocation of large vessels and nerves of the mediastinum. This anatomical specificity is an imminent threat to successful treatment, and it also carries a certain risk of asphyxia and sudden death of the patient. In this clinical case, radical surgical treatment in this patient included sequential mobilization in two pleural cavities, and then the total removal of T through the traditional surgical access. The anesthetic complexity to support the surgical intervention involved both difficult intubation due to tracheal stenosis, and also the required separate ventilation of the lungs to visualize anatomical structures and mobilize a multinodular formation in two pleural cavities. Standard methods of artificial lung ventilation could be ineffective and even dangerous in this case due to the location and size of the tumor. We focused our attention on high-frequency ventilation (HFV), the best method of respiratory support during surgeries for tracheal and bronchial pathologies. The main task of the anesthetic team in this clinical case was to prevent the development of hypercapnia and hypoxia during intubation of the stenotic tracheal segment, and then adequate ventilation of the lungs with reduced area of proper gas exchange due to bilateral surgical pneumothorax. Thus, the full treatment was carried out due to the only safe method of compensating lung ventilation with anesthesia by HFV. The applied HFV method creates an adequate gas exchange in the lungs due to the small ventilation volume and high frequency of respiratory cycles per minute. HFV both prevented the development of threatening complications during intubation of the stenotic tracheal area and ensured an adequate gas exchange during successive thoracoscopic stages of thyroid tumor mobilization.
Immunologic aspects of colorectal cancer progression
Authors: Tishina A. V. , Vladimirova L. Yu. , Sagakyants A. B. , Dzhenkova E. A. , Novikova I. A. , Zlatnik E. Yu. 
Published: March 2024

Colorectal cancer remains in the leading positions in the structures of morbidity and mortality among both sexes. A large number of studies are aimed to reveal new biomarkers targeted at both early diagnosis and improving the effectiveness of drug therapy. Colorectal carcinoma (CC) is heterogeneous in its morphological, molecular and immunological aspects and is a heterogeneous disease. The existing molecular genetic classifications and biomarkers capable of predicting the effectiveness of therapy aren’t optimal enough. New prognostic markers would make it possible to identify a subgroup of patients with a high risk of tumor recurrence, for whom enhanced monitoring and diagnostic monitoring should be established, as well as the selection of highly effective methods in the treatment of colorectal cancer. It has been established that some immune cells in the tumor microenvironment are able to stimulate the development of disease progression. Cytokines and chemokines in the tumor microenvironment stimulate the development of metastases, and their serum levels reflect the current inflammatory response in the tumor tissue. The identification and analysis of immune markers involved in the processes of metastasis and the mechanisms of progression remains an important task of modern medicine. The purpose of the study was to analyze modern ideas about the importance of the immunological microenvironment in the progression of colorectal cancer. The effect of molecular heterogeneity of the tumor on the development of metastases, as well as on resistance to ongoing antitumor therapy. The review reflects the immunological characteristics of CC, including in the context of molecular biological subtypes. It describes the involvement of cells of the immune system (lymphocytes, macrophages) and their products (cytokines, chemokines) in the progression of colorectal cancer, including in the processes of neoangiogenesis, as well as the relationship of the T- and B-cell composition of the tumor microenvironment on the course of the disease. The review also shows the immunogenomic stratification of CC, which can be used to predict the response to immunotherapy for colorectal cancer.
O PAPEL DA INTELIGÊNCIA ARTIFICIAL (IA) NA EDUCAÇÃO A DISTÂNCIA
Authors: Oliveira Ricardo Furtado de , Silva Ana Walquíria Souza da , Vilela Márcia Alves Medeiros , Ribeiro Priscilla Eustáquio de Oliveira , Santos Sonia Araújo dos 
Published: March 2024

O presente trabalho tem por objetivo geral apresentar uma pesquisa bibliográfica sobre a Inteligência Artificial nos cursos do ensino superior. Atualmente a educação a distância tem avançado nos seus métodos de ensino, uma das ferramentas utilizadas tem sido a Inteligência Artificial, mas é questionado quais as vantagens e desvantagens dessa nova ferramenta na modalidade de ensino a distância? Assim, o método utilizado nesta pesquisa foi um estudo bibliográfico realizado por meio de sites acadêmicos com autores atuais de 2018 a 2023. Por fim, pode-se considerar que a IA nos cursos a Distancia tem sido uma ferramenta de grande suporte para o desenvolvimento educacional tanto dos alunos quanto dos professores, a desvantagem é quando os docentes e discentes sentem dificuldade de utilizar dessa ferramenta e acabam manuseando a máquina de forma equivocada, o que pode gerar resultados incorretos, outro ponto negativo é que os computadores podem apresentar falhas nos seus sistemas e isso, pode ocorrer por ser maquinas, o que precisa do manuseio humano para ser ajustada. No geral a AI, deve ser utilizada por alunos que desejam continuar os estudos só que de forma online, sendo que essa modalidade de ensino se mostra muito eficiente especialmente com a inteligência artificial, que tem demonstrado diversas vantagens, como a possibilidade de permitir pesquisas acadêmica, em bibliotecas virtuais, detector de plágios e outros.
PENINGKARAN KARAKTER DENGAN ORGANISASI LUAR SEKOLAH
Authors: Itsna Rusydiana  , Nur Fadhilah Isnaini , Fediana Mustofa Dise , Hakim Lukman , Nur Hidayati Maidina , Rahmawati Aullia 
Published: March 2024

Abstract
The Ngreco branch of the IPNU-IPPNU organization plays a crucial role in shaping individual character through a series of activities held by its management, including khataman, carnival and management meetings. Active support from the surrounding community, both in the form of direct participation and provision of facilities, is an important factor in the success of organizational activities. Continuous interaction between organizational members and the community is a strategy to maintain this support. When facing obstacles, the management and members of the organization carry out deliberations and evaluations to improve the implementation of activities in the future. Organization members, as resource persons, demonstrated the positive impact of their participation in organizational activities, including increasing self-confidence and building good character. Despite admitting a lack of experience in carrying out leadership roles, members still try to overcome obstacles, showing the development of the character of independence and cohesion within the organization. Collaboration with other organizations is also part of the strategy to strengthen friendship and collaboration in organizational activities. Overall, the roles and interactions within the Ngreco branch of the IPNU-IPPNU organization strengthen the formation of quality youth character.
Keywords: Ngreco branch of the IPNU-IPPNU organization; Formation of adolescent character.
Green Marketing at ITC Limited
Authors: Mrs. Ruqia Fatima  , Mrs. Azra Fatima  
Published: March 2024

Green marketing is a phenomenon which has developed particular important in the modern marketing era. While company adopting green marketing, at the same time there are a number of problems that must overcome. One of the main problems is that firms using green marketing must ensure that their activities are not misleading to consumers or industry and do not breach any of the regulations or laws dealing with environmental marketing. Eco- friendly manufacturing, eco-friendly packaging and recycling the waste generated in the process - all a part of Green Marketing - are the key strategies that companies are adopting to sustain in the changing scenario. This study aims to give information about the effect of green marketing on customers purchasing behaviors and also to evaluate the initiatives taken by the Indian Tobacco Company Limited in their core business. This paper also focuses on green marketing mix and the strategies for success of Green Marketing.
An Empirical Analysis of Tribal Investors’ Behaviour - A Study of Selected States in North East India
Authors: Dinesh Darnal  , Abhijit Dutta  
Published: March 2024

This study tries to understand the behaviour and perception of the tribal investors in the North Eastern India. This study tried to find out using several non- parametric test and factor analysis what are the investment avenues the population in the study responded to and the behaviour. From the study we understood the behaviour of the tribal investors of north east part of India in respect of selected states. The results of the Mann Whitney test in respect show that investment in respect of the Gold, Real Estate and Post office saving are significant across gender in the study. This indicates that these are more important in terms of investment in respect of decision of investment. In terms of significance for self-decision real estate, banking and post office saving are the clear winners and this is quite obvious given the demographic spread of age group and income level and the sector of employment. Earlier studies have shown that government employees at the higher age group are generally risk averse and tend to invest in stable low return assets. Post office savings show as the only significant investment avenue in term of annual income of the tribal investors.
Impact of Marketing Strategies on Consumer Buying Behaviour with Specific Reference to Movies as a Medium
Authors: Surya Kumar  , Tanya Sharma  
Published: March 2024

The research aims to investigate how film promoters' social media activities and other factors influence public decision-making regarding watching films in theatres. Specifically focusing on film audiences in Tamil Nadu, the study evaluates public perceptions and social media engagement. Limited research has explored variables like promotional campaigns, social media engagement, reviews, and decision-making regarding movie-watching. The study surveyed 300 individuals from Tamil Nadu who had watched films and by using SPSS, statistical analysis has been done to compare results and identify significant relationships influencing consumer decisions. The research highlights the importance of promotional campaigns, social media engagement, and reviews in influencing audiences' movie choices. Social media references can enhance audience enjoyment of recommended films, with social awareness also impacting video screening standards. The findings indicate that social networks play a significant role in influencing movie-watching behaviour. Overall, a combination of factors is necessary to encourage audiences to watch movies, and further exploration of strategies is essential to boost theatre attendance.
ECO-INNOVATIVE GRAPHIC DESIGN PRACTICES: LEVERAGING FINE ARTS TO ENHANCE SUSTAINABILITY IN INDUSTRIAL DESIGN
Authors: Joshua Alahira  , Nwakamma Ninduwezuor-Ehiobu  , Kehinde Andrew Olu-lawal  , Emmanuel Chigozie Ani  , Irunna Ejibe  
Published: March 2024

The intersection of graphic design and sustainability presents a dynamic arena for eco-innovative practices, particularly in the realm of industrial design. This review explores the integration of fine arts principles within graphic design to enhance sustainability initiatives in industrial design processes. The essence lies in leveraging the creative potential of graphic design to foster ecologically conscious solutions, thus contributing to the broader ethos of sustainable development. Eco-innovative graphic design practices encompass a range of strategies aimed at minimizing environmental impact while maximizing aesthetic and functional value. Drawing inspiration from fine arts disciplines, such as painting, sculpture, and photography, designers infuse their work with elements that reflect ecological awareness and responsibility. By integrating themes of nature, conservation, and sustainable living into visual communication, graphic designers play a pivotal role in raising awareness and inspiring action towards sustainable practices. In the context of industrial design, the collaboration between graphic designers and product developers yields innovative solutions that prioritize environmental sustainability. Through thoughtful consideration of materials, production processes, and end-of-life disposal, eco-innovative graphic design practices contribute to the creation of products that are both visually compelling and ecologically sound. Whether through the use of recycled materials, minimalist packaging designs, or biodegradable components, graphic designers harness their artistic prowess to redefine the parameters of sustainable design. Moreover, eco-innovative graphic design practices extend beyond the realm of physical products to encompass digital experiences and branding initiatives. Through digital platforms, designers have the opportunity to promote sustainability messaging, advocate for environmental causes, and encourage behavior change towards more eco-conscious consumption patterns. In conclusion, the integration of fine arts principles within graphic design serves as a catalyst for enhancing sustainability in industrial design. By leveraging creativity, innovation, and visual communication, designers have the power to shape a more sustainable future where ecological considerations are central to the design process. Embracing eco-innovative graphic design practices is not merely a stylistic choice but a conscientious commitment towards harmonizing human creativity with the imperatives of environmental stewardship.
Keywords: Eco-Innovative, Graphic Design, Fine Arts, Industrial Design, Sustainability, Review.
IMPLEMENTING AI-DRIVEN WASTE MANAGEMENT SYSTEMS IN UNDERSERVED COMMUNITIES IN THE USA
Authors: Zamathula Queen Sikhakhane Nwokediegwu  , Ejike David Ugwuanyi  
Published: March 2024

The integration of Artificial Intelligence (AI) technologies holds immense potential for revolutionizing waste management systems in underserved communities across the United States. This concept paper explores the feasibility, benefits, challenges, and implications of implementing AI-driven waste management systems in these communities. By leveraging AI capabilities such as predictive analytics, optimization algorithms, and IoT sensors, innovative solutions can be developed to enhance waste collection, recycling efficiency, and environmental sustainability. However, successful implementation requires careful consideration of socioeconomic factors, community engagement, privacy concerns, and infrastructure limitations. This paper aims to provide a comprehensive overview of the opportunities and considerations associated with deploying AI-driven waste management systems in underserved communities, ultimately striving to promote equitable access to efficient and sustainable waste management solutions. This concept paper provides a comprehensive framework for implementing AI-driven waste management systems in underserved communities in the USA. It examines various aspects including socioeconomic considerations, community engagement, privacy concerns, infrastructure requirements, policy frameworks, financing options, and sustainability measures. Through careful planning, collaboration, and innovation, AI technologies can be harnessed to address the unique challenges faced by underserved communities, ultimately leading to more efficient, equitable, and sustainable waste management practices.
Keywords: AI, Community, Waste, USA.
INTELLIGENT MONITORING SYSTEM FOR REAL-TIME OPTIMIZATION OF ULTRA-PRECISION MANUFACTURING PROCESSES
Authors: Adeniyi Kehinde Adeleke  
Published: March 2024

In the realm of ultra-precision manufacturing, the minutiae of process control and material handling are paramount to achieving the highest levels of product quality and manufacturing efficiency. The industry faces a significant challenge: maintaining and enhancing the precision of manufacturing processes in real-time to ensure optimal output quality while minimizing waste and energy consumption. This challenge is compounded by the increasing complexity of products and the materials used, requiring ever more precise and adaptive manufacturing techniques. The importance of addressing this challenge cannot be overstated, as it directly impacts the competitiveness, sustainability, and innovation capacity of manufacturing firms. The development of an intelligent monitoring system that integrates advanced precision metrology techniques presents a promising solution to this problem. Such a system would enable real-time optimization of manufacturing processes, leveraging cutting-edge technologies and data analytics to dynamically adjust parameters for optimal performance. By doing so, it would not only enhance the precision and efficiency of manufacturing operations but also contribute significantly to sustainable manufacturing practices by reducing waste and energy consumption. This concept paper proposes the development of this intelligent monitoring system, outlining its potential impact on the ultra-precision manufacturing industry.
Keywords: Ultra Precision, Monitoring, Processing, Real Time.
ENSURING GLOBAL FOOD SAFETY: INTEGRATING BLOCKCHAIN TECHNOLOGY INTO FOOD SUPPLY CHAINS
Authors: Osato Itohan Oriekhoe  , Bamidele Segun Ilugbusi  , Olawale Adisa  
Published: March 2024

This concept paper explores the integration of blockchain technology into food supply chains to enhance global food safety. In recent years, food safety has become a critical concern worldwide, with frequent outbreaks of foodborne illnesses and contamination incidents. Traditional supply chain systems often lack transparency, traceability, and efficiency, leading to challenges in identifying the source of contamination and preventing its spread. Blockchain technology offers a promising solution to these challenges by providing a decentralized, immutable, and transparent ledger system. By recording each transaction and transfer of food products on a blockchain, stakeholders can trace the journey of food items from farm to fork in real-time. This enables rapid identification of contaminated products, facilitating targeted recalls and reducing the scope and impact of foodborne illness outbreaks. Key benefits of integrating blockchain technology into food supply chains include enhanced transparency, increased trust among consumers, improved efficiency in recalls and audits, and opportunities for process optimization and cost reduction. However, successful implementation requires collaboration among stakeholders, investment in infrastructure, and addressing technical and regulatory challenges. This concept paper outlines a strategic framework for implementing blockchain technology in food supply chains, including stakeholder engagement, pilot testing, scalability considerations, and regulatory compliance. By leveraging blockchain technology, we can ensure greater food safety, protect public health, and strengthen confidence in the global food supply chain.
Keywords: Food Safety, Blockchain, Technology, Supply.