bluuebunny/crossref_metadata_2025_split huggingface dataset:
The microbial spectrum and antimicrobial resistance pattern in pediatric cancer patients with febrile neutropenia at King Abdullah University Hospital, Jordan
Authors: Alzu’bi Diya , Obeidat Hanady , Ghabashineh Dua’a , AbuRass Omayma , Musadag Ola , Samara Dua’ N. , Al Droubi Belal , Abdelhady Gamal T. , Al-Sweedan Suleimman 
Published: March 2024

Abstract
Background
Febrile neutropenia (FN) is a life-threatening complication of cancer therapy. Appropriate antibiotic treatment improves the clinical outcome in these patients; however, the increasing rate of anti-microbial resistance makes its therapy particularly challenging.

Aim
This study aims to investigate the microbial spectrum and antimicrobial resistance pattern in cancer patients with FN at King Abdullah University Hospital, Jordan.

Method
Blood cultures of 261 FN patients pre-diagnosed with malignancy (age 1–18 years) were enrolled in this study.

Results
The most common isolated microorganisms were gram-positive bacteria (50.2℅). Gram-infections with coagulase-negative Staphylococcus (CONS) are the most prevalent pathogens, followed by gram-negative infections with Klebseilla pneumonia and fungal infections with nonalbicans strains. All CONS, Methicillin-resistant Staphylococcus aureus (MRSA), and enterococcus species were sensitive to Vancomycin and Teicoplanin. Ten percent of the gram-negative organisms were Extended-spectrum beta-lactamase (ESBL) and all were sensitive to carbapenems. 66.7% of pseudomonas aeruginosa blood cultures were sensitive to Piperacillin-Tazobactam and 83.4% were sensitive to carbapenems. All Enterobacter species were sensitive to Carbapenems.

Conclusion
Isolates showed various antibiotic sensitivity and resistance patterns; therefore, a judicious management plan is essential to establish an appropriate and effective institutional policy for the use of empirical antibiotics in patients of FN.
Combined onshore and offshore wide-scale seismic data acquisition and imaging for carbon capture and storage exploration in Havnsø, Denmark
Authors: Zappalá Samuel , Malehmir Alireza , Papadopoulou Myrto , Gregersen Ulrik , Funck Thomas , Clausen Ole R. , Nørmark Egon 
Published: March 2024

Strong global actions for climate change include carbon capture and storage (CCS) as a feasible solution to reach carbon neutrality and raise opportunities for detailed subsurface investigations. An acquisition set-up designed for onshore-offshore zones was maximized for wide-scale high-resolution structural imaging and implemented to cover a domal structure of interest for CCS utilization close to the town of Havnsø (Denmark). The challenges of the combined acquisition and processing of land and marine multisensor data along a 42 km seismic profile are analyzed, the suggested solutions are applied, and the limitations are discussed. On the onshore side, a nodal array and a seismic landstreamer system were simultaneously used, whereas along the transition zone, a marine seismic streamer and ocean-bottom seismometers were added to record the seismic response generated by two seismic vibrator sources. The adopted sensing domains (velocity, acceleration, and pressure) were studied, and different processing steps were evaluated to enable their processing and subsequent data set merging. Results suggest, as the best approach, a separate prestack processing of the different data sets and the computation of new geometries and new surface-consistent residual static correction after their merging. The data acquired in the transition zone illuminate, for the first time, the subsurface geology of the region, delineating an expected domal closure. The final seismic section shows high continuity of the reflections with good resolution along the entire profile, identifying the main reservoir structure and the surrounding areas, which are important to ensure reservoir integrity and safe exploitation over longer time scales. Shallow and deep reflections are consistent with the stratigraphic column from a well log near the profile. The presented study shows a comprehensive workflow for processing such a multisensor data set in onshore and transition zone settings.
Opening Up
Authors: Stuer Catherine 
Published: March 2024

AbstractThis article analyzes photographs of the city of Nanjing collected in the last years of the nineteenth century by Robert Löbbecke (1852–1910), a German military captain and engineer working in service of Chinese military reforms by leaders of the Self-Strengthening Movement. Spanning almost three decades and including the earliest known dated photos of Nanjing, more than half of the large albumen prints in this collection can be attributed to Chinese photographers, including the local branch of Ouyang Shizhi's (1857–1932) Powkee studio. They offer rare insights into both the early work by this famous studio and early Chinese photography of place, focusing on a city that stood at the center of struggles over China's political and economic survival. As such, this collection offers exceptional terrain to explore relations of photography to place, identity, and power in nineteenth-century China. To unpack these relations, I analyze Löbbecke's collection as part of photography's multivalent encounters with the city in nineteenth-century China. I start with the photographic encounters with the Chinese city in the work and writings of Jules Itier (1802–1877) and John Thomson (1837–1921), and then explore what the Löbbecke collection reveals about the visions its photos made possible for their expatriate collector and for their Chinese makers and audiences, with a special focus on Ouyang Shizhi's Nanjing studio enterprise. I conclude with a reflection on a more recent moment when the photos collected by Löbbecke returned home a century after their making to participate in the telling of new kinds of urban histories.
Macrophages play a nutritive role in post-metamorphic maturation in Drosophila
Authors: Krejčová Gabriela , Danielová Adéla , Sehadová Hana , Dyčka Filip , Kubásek Jiří , Moos Martin , Bajgar Adam 
Published: March 2024

ABSTRACT
In the body of multicellular organisms, macrophages play an indispensable role in maintaining tissue homeostasis by removing old, apoptotic and damaged cells. In addition, macrophages allow significant remodeling of body plans during embryonic morphogenesis, regeneration and metamorphosis. Although the huge amount of organic matter that must be removed during these processes represents a potential source of nutrients, their further use by the organism has not yet been addressed. Here, we document that, during metamorphosis, Drosophila larval adipose tissue is infiltrated by macrophages, which remove dying adipocytes by efferocytosis and engulf leaking RNA-protein granules and lipids. Consequently, the infiltrating macrophages transiently adopt the adipocyte-like metabolic profile to convert remnants of dying adipocytes to lipoproteins and storage peptides that nutritionally support post-metamorphic development. This process is fundamental for the full maturation of ovaries and the achievement of early fecundity of individuals. Whether macrophages play an analogous role in other situations of apoptotic cell removal remains to be elucidated.
Curvilinear walking elevates fall risk and modulates slip and compensatory step attributes after unconstrained human slips
Authors: Rasmussen Corbin M. , Mun Seongwoo , Ouattas Abderrahman , Walski Andrew , Curtze Carolin , Hunt Nathaniel H. 
Published: March 2024

ABSTRACTWhile much attention has been paid to understanding slip-related falls in humans, little has been focused on curvilinear paths despite their prevalence, distinct biomechanical demands and increased slipping threat. We determined the mechanics, compensatory stepping reactions and fall risk associated with slips during fixed-speed walking across ranges of path curvature, slipped foot and slip onset phase contexts possible in the community, which builds upon previous work by examining speed-independent effects of curvilinear walking. Twenty-one participants experienced 15 unconstrained slips induced by a wearable friction-reducing device as motion capture and harness load cell data were recorded. Falls were most likely after early stance slips to the inside foot and increased at tighter curvatures. Slip distance and peak velocity decreased as slips began later in stance phase, did not differ between feet, and accelerated on tighter paths. Slipping foot directions relative to heading transitioned from anterior (forward) to posterior (backward) as slips began later in stance, were ipsilateral (toward the slipping foot side) and contralateral (toward the opposite side) for the outside and inside foot, respectively, and became increasingly ipsilateral/contralateral on tighter curvatures. Compensatory steps were placed anteriorly and ipsilaterally after outside and inside foot slips, respectively, and lengthened at later onset phases for outside foot slips only. Our findings illustrate slip magnitude and fall risk relationships that suggest slip direction may influence the balance threat posed by a slip, imply that walking speed may modify slip likelihood, and indicate the most destabilizing curved walking contexts to target in future perturbation-based balance training approaches.
STUDY OF STRESS-PROTECTIVE AND ANXIOLYTIC ACTIONS OF SCUTELLARIA BAICALENSIS GEORGI EXTRACT UNDER "SOCIAL" STRESS
Authors: Uranova Valeria V. , Lomteva Natalia A. , Kuleshova Olga N. 
Published: March 2024

Background. The search for natural adaptogens is promising due to the possibility of expanding the range of drugs that contribute to the adaptation of the body to adverse environmental factors.
Purpose. To study the stress-protective and anxiolytic action of the extract of Scutellaria baicalensis Georgi under conditions of "social" stress.
Materials and methods. We used an extract of Scutellaria baicalensis Georgi. The study of the stress-protective and anxiolytic effects of the extract was carried out on 84 male non-linear rats aged 7-9 months. The first stage of the experiment involved the study of pharmacological actions in the absence of stress, and at the second stage, under conditions of “social” stress, the expected effects were determined on animals, in the groups of which individuals of dominant and submissive types of behavior were identified. Determination of the content of corticosterone, adrenaline and noradrenaline (nmol/l) was carried out by enzyme immunoassay.
Results. It was established that in the norm, the experimental groups that received the extract of Scutellaria baicalensis Georgi, medicinal products "Mebikar®" and "Phezam®" showed a significant decrease in the level of corticosterone compared with the control group. At the second stage of the study in groups when modeling "social" stress, it was found that there were significant differences between the concentration of stress hormones in animals of dominant and submissive types. Administration of Scutellaria baicalensis Georgi extract reduced hormone levels for both aggressors and victims relative to the stressed control group. We observed a decrease in the concentration of corticosterone by 1.5 and 1.5 (p<0.05) times, the level of adrenaline by 3.2 and 3.1 (p<0.05) times, the content of norepinephrine by 1.6 and 1.6 (p<0.05) times for individuals of dominant and submissive types, respectively. The presence of the leveling effect of the Scutellaria baicalensis Georgi extract proves its anxiolytic and stress-protective effect.
Conclusion. Scutellaria baicalensis Georgi extract at a dose of 100 mg/kg/day, when exposed to "social" stress, has a stress-protective and anxiolytic effect, reducing the severity of stress-induced changes, limiting hyperactivation of the central stress-realizing systems, correcting the endogenous antioxidant system of the body.
CONTENT OF PHOTOSYNTHETIC PIGMENTS IN LEAVES OF THE GENUS ACER L. SPECIES IN URBAN ENVIRONMENT
Authors: Chernyavskaya Irina V. , Ednich Evgenia M. , Tolstikova Tatyana N. 
Published: March 2024

Background. Pigment concentration is a species trait, and is an integral indicator of adaptive response to changes in environmental factors and the growing conditions. The intensive development of modern cities imposes certain requirements on the selection of plants for landscaping, one of which is a high level of adaptive responses.
Purpose. The purpose of this study was to determine the content of photosynthetic pigments in the leaves of the genus Acer species in urban conditions of the city of Maуkop, the Adygea Republic.
Materials and methods. We used the spectrophotometric method to determine the content of photosynthetic pigments in the leaves of the genus Acer L. species: A. platanoides, A. pseudoplatanus, A. saccharinum, A. negundo, A. campestre in an urban environment of the city of Maуkop and the zone of conditional control (Botanical garden). We carried out statistical processing of experimental data by using the MS Excel 2010 package.
Results. We have revealed that in the conditions of an urbanized environment the total content of chlorophylls is 1.1-2.2 times higher in comparison with that of the zone of control. Taking into account the level of variability of the total content of green pigments in the city, we arranged the studied species in the following order: A. saccharinum A. campestre ˂ A. pseudoplatanus ˂ A. platanoides ˂ A. negundo. The ratio of the amount of chlorophylls to carotenoids reacted very sensitively to the impact of urban environmental factors. A. campestre and A. saccharinum differed from A. negundo, A. pseudoplatanus, and A. platanoides for this indicator.
Conclusion. The study made allow us to state that in the conditions of an urbanized environment, the studied species of the genus Acer undergo restructuring in the structure of pigment complexes. An increase in the synthesis of chlorophylls and carotenoids raises their adaptive capabilities to the negative impact of urban environmental factors.
IMPROVED TECHNOLOGIES FOR GROWING SEEDLINGS OF FOREST-FORMING SPECIES IN THE VOLGOGRAD REGION
Authors: Sapronova Daria V. , Belyaev Alexander I. , Semenyutina Alexandra V. , Khuzhakhmetova Aliya Sh. , Sapronov Vasiliy V. 
Published: March 2024

Background. Issues on improvement of technologies of cultivation of planting material are associated with the need to intensify this process to provide an accessible and adapted assortment of woody species. Modern strategies for implementation of natural climatic solutions on degraded lands of Volgograd region provide for attraction of forest-forming adaptive tree species: Quercus (39,8%), Pinus (15,8%), Populus (7,5%).
Purpose. Improve the technology of production of Quercus robur planting material.
Materials and methods. On the basis of the Nizhnevolzhsk tree breeding station - a branch of the Federal Research Center of Agroecology RAS (Kamyshin, Volgograd Region), outdoor and indoor plots were allocated to improve production technology. Certified seed material Quercus robur L. (certificate of quality №34/25675, 34/25727) was used in the experiments. To ensure optimal conditions for development, the scheme of irrigation and nutrient regime (ammonium nitrate, Solar universal) were developed. Experimental data on the growth of seedlings were processed by methods of mathematical processing. The standard of seedlings is determined in accordance with the Order of the Ministry of Natural Resources of Russia from 04.12.2020 № 1014.
Results. The effectiveness of growing seedlings Quercus robur L. with closed and open root systems is shown. The characteristics of the substrate are given, the regime of mineral nutrition, as well as the regime of watering to maintain the optimum temperature and humidity of the air and substrate are developed. Analysis of the dynamics of biometric data of plants with closed root system showed that 92% reached the standard within 2 months, with open root system - 56% of seedlings at the end of the growing season.
Conclusion. According to the indicators of quality, time and volume of production, the advantage of the technology of growing Q. robur L. with closed root system.
Parametric Semidefinite Programming: Geometry of the Trajectory of Solutions
Authors: Bellon Antonio , Henrion Didier , Kungurtsev Vyacheslav , Mareček Jakub 
Published: March 2024

In many applications, solutions of convex optimization problems are updated on-line, as functions of time. In this paper, we consider parametric semidefinite programs, which are linear optimization problems in the semidefinite cone whose coefficients (input data) depend on a time parameter. We are interested in the geometry of the solution (output data) trajectory, defined as the set of solutions depending on the parameter. We propose an exhaustive description of the geometry of the solution trajectory. As our main result, we show that only six distinct behaviors can be observed at a neighborhood of a given point along the solution trajectory. Each possible behavior is then illustrated by an example. Funding: This work was supported by OP RDE [Grant CZ.02.1.01/0.0/0.0/16_019/0000765].
Dehydrated human amnion/chorion membrane to treat venous leg ulcers: a cost-effectiveness analysis
Authors: Tettelbach William H , Driver Vickie , Oropallo Alisha , Kelso Martha R , Niezgoda Jeffrey A , Wahab Naz , Jong Julie L De , Hubbs Brandon , Forsyth R Allyn , Magee Gregory A , Steel Paul , Cohen Benjamin G , Padula William V 
Published: March 2024

Objective: To evaluate the cost-effectiveness of dehydrated human amnion/chorion membrane (DHACM) in Medicare enrolees who developed a venous leg ulcer (VLU). Method: This economic evaluation used a four-state Markov model to simulate the disease progression of VLUs for patients receiving advanced treatment (AT) with DHACM or no advanced treatment (NAT) over a three-year time horizon from a US Medicare perspective. DHACM treatments were assessed when following parameters for use (FPFU), whereby applications were initiated 30–45 days after the initial VLU diagnosis claim, and reapplications occurred on a weekly to biweekly basis until completion of the treatment episode. The cohort was modelled on the claims of 530,220 Medicare enrolees who developed a VLU between 2015–2019. Direct medical costs, quality-adjusted life years (QALYs), and the net monetary benefit (NMB) at a willingness-to-pay threshold of $100,000/QALY were applied. Univariate and probabilistic sensitivity analyses (PSA) were performed to test the uncertainty of model results. Results: DHACM applied FPFU dominated NAT, yielding a lower per-patient cost of $170 and an increase of 0.010 QALYs over three years. The resulting NMB was $1178 per patient in favour of DHACM FPFU over the same time horizon. The rate of VLU recurrence had a notable impact on model uncertainty. In the PSA, DHACM FPFU was cost-effective in 63.01% of simulations at the $100,000/QALY threshold. Conclusion: In this analysis, DHACM FPFU was the dominant strategy compared to NAT, as it was cost-saving and generated a greater number of QALYs over three years from the US Medicare perspective. A companion VLU Medicare outcomes analysis revealed that patients who received AT with a cellular, acellular and matrix-like product (CAMP) compared to patients who received NAT had the best outcomes. Given the added clinical benefits to patients at lower cost, providers should recommend DHACM FPFU to patients with VLU who qualify. Decision-makers for public insurers (e.g., Medicare and Medicaid) and commercial payers should establish preferential formulary placement for reimbursement of DHACM to reduce budget impact and improve the long-term health of their patient populations dealing with these chronic wounds. Declaration of interest: Support for this analysis was provided by MiMedx Group, Inc., US. JLD, and RAF are employees of MiMedx Group, Inc. WHT, BH, PS, BGC and WVP were consultants to MiMedx Group, Inc. VD, AO, MRK, JAN, NW and GAM served on the MiMedx Group, Inc. Advisory Board. MRK and JAN served on a speaker's bureau. WVP declares personal fees and equity holdings from Stage Analytics, US.
Before and after COVID-19: Changes in symptoms and diagnoses in 13,033 adults
Authors: Butler Mark J. , Chiuzan Codruta , Ahn Heejoon , Gao Michael , D’Angelo Stefani , Yeh Jackson , Davidson Karina 
Published: March 2024

Background
Most patients with COVID-19 report experiencing one or more symptoms after acute infection subsides, known as post-acute sequelae of SARS-CoV-2 infection (PASC). Though research has examined PASC after acute COVID-19, few studies have examined PASC over a longer follow-up duration or accounted for rates of symptoms and diagnoses before COVID-19 infection, and included those not actively seeking treatment for PASC. To determine what symptoms and diagnoses are occurring at higher rates after acute COVID-19 infection from a more inclusive sample, we extracted electronic hospital records (EHR) data from 13,033 adults with previously known diagnoses and symptoms.

Methods
The sample was comprised of patients who had a positive PCR test for SARS-CoV-2 between March 1, 2020, and December 31, 2020, and follow-up was conducted through November 29, 2021. All patients in the sample had medical appointments ≥4 weeks before and ≥4 weeks after their positive PCR test. At these appointments, all ICD-10 codes recorded in the EHR were classified into 21 categories based on the literature and expert review. Conditional logistic regression models were used to quantify the odds of these symptoms and diagnostic categories following COVID-19 infection relative to visits occurring before infection. The sample was comprised of 28.0% adults over 65 and was 57.0% female. After the positive PCR test, the most recorded diagnoses and symptoms were dyspnea and respiratory failure, myositis, musculoskeletal pain/stiffness, anxiety, and depression.

Results
Results from regression analyses showed increased odds of diagnosis for 15 of the 21 categories following positive PCR. Relative to pre-COVID, the diagnoses and symptoms with the greatest odds after a positive PCR test were loss of smell or taste [OR (95% CI) = 6.20 (3.18–12.09)], pulmonary fibrosis [3.50 (1.59–7.68)], and dyspnea/respiratory failure [2.14 (1.92–2.40)]. Stratification of these analyses by age, gender, race, and ethnicity showed similar results.

Conclusion
The increased symptoms and diagnoses detected in the current study match prior analyses of PASC diagnosis and treatment-seeking patients. The current research expands upon the literature by showing that these symptoms are more frequently detected following acute COVID-19 than before COVID-19. Further, our analyses provide a broad snapshot of the population as we were able to describe PASC among all patients who tested positive for COVID-19.