bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capillary malformation of the lower lip, lymphatic malformation of the face and neck, asymmetry and partial/generalized overgrowth (CLAPO): Report of six cases of a new syndrome/association
Authors: López‐Gutiérrez Juan Carlos , Lapunzina Pablo 
Published: September 2008

AbstractWe report on six patients with clinical findings consisting of (1) Capillary malformation (CM) of the lower lip; (2) Lymphatic malformation (LM) of the face/neck; (3) Asymmetry of face and limbs, and (4) Partial/ generalized Overgrowth. This constellation of findings has been observed in six unrelated patients, constituting a likely “new” syndrome/association of capillary‐lymphatic‐venous malformation and asymmetric overgrowth. © 2008 Wiley‐Liss, Inc.
Palladium‐ und Gold‐Palladium‐Katalysatoren für die Direktsynthese von Wasserstoffperoxid
Authors: Edwards Jennifer K. , Hutchings Graham J. 
Published: September 2008

AbstractWasserstoffperoxid wird heutzutage durch einen indirekten Prozess produziert, der auf der sequenziellen Hydrierung und Oxidation eines Alkylanthrachinons beruht. Auf diese Weise werden der Wasserstoff und Sauerstoff während des Produktionsprozesses voneinander getrennt gehalten. Ein Prozess, in dem molekularer Sauerstoff direkt hydriert wird, könnte Vorteile bringen, sofern man die sequenzielle Hydrierung kontrollieren kann und hohe Umsatzgeschwindigkeiten bei gleichzeitig sicheren und explosionsfreien Bedingungen erzielt werden. In diesem Kurzaufsatz beschreiben wir jüngste Fortschritte bei der Direktsynthese von Wasserstoffperoxid an trägerfixierten Palladium‐ und Gold‐Palladium‐Katalysatoren und analysieren einige der Probleme, die es noch zu überwinden gilt.
Hydrodynamics characterization of a counter‐current spray column for particulate scrubbing from flue gases
Authors: Biswas S. , Rajmohan B. , Meikap B. C. 
Published: September 2008

AbstractGrowing environmental concern and tightening of the regulations for particulate emission from various sources force us to think of an alternative technology for their control, which is cost effective and of high performance. A spray column using a wet process to control the particulates offers design simplicity, and has various other advantages over other conventional equipment used in industry. This work presents the hydrodynamic study of the spray column for the removal of particulates from gaseous wastes. Experiments were carried out to quantify pressure drop (ΔP), for varied gas and liquid rates ranging from 3.084 × 10−3 to 5.584 × 10−3 Nm3/s and 8.35 × 10−6 to 33.34 × 10−6 m3/s, respectively with QL/QG ratio ranging from 1.59 to 10.81 m3 per 1000 ACM (actual cubic meter). The maximum pressure drop incurred in the column is 327 N/m3, which is at a gas rate of 5.584 × 10−3 Nm3/s, liquid rate of 33.34 × 10−6 m3/s, and an inlet solid loading range of 0–2.5 kg/m3. This is quite low compared to other wet process‐based equipment, thus making it a low power loss scrubber. These results have further demonstrated the impact of solid dust (particulates) on the pressuredrop‐hydrodynamics. A correlation was put forward for prediction of the overall pressure drop in the column. The experimental values agreed well with the predicted values, with minimum percentage error and standard deviation. Copyright © 2008 Curtin University of Technology and John Wiley & Sons, Ltd.
The in vitro Characterization of Polyene Glycosyltransferases AmphDI and NysDI
Authors: Zhang Changsheng , Moretti Rocco , Jiang Jiqing , Thorson Jon S. 
Published: September 2008

AbstractThe overproduction, purification, and in vitro characterization of the polyene glycosyltransferases (GTs) AmphDI and NysDI are reported. A novel nucleotidyltransferase mutant (RmlA Q83D) for the chemoenzymatic synthesis of unnatural GDP–sugar donors in conjunction with polyene GT‐catalyzed sugar exchange/reverse reactions allowed the donor and acceptor specificities of these novel enzymes to be probed. The evaluation of polyene GT aglycon and GDP–sugar donor specificity revealed some tolerance to aglycon structural diversity, but stringent sugar specificity, and culminated in new polyene analogues in which L‐gulose or D‐mannose replace the native sugar D‐mycosamine.
Iron–Sulfur Cluster Biogenesis Systems and their Crosstalk
Authors: Xu Xiang Ming , Møller Simon G. 
Published: September 2008

AbstractThe biogenesis of iron–sulfur clusters ([FeS]) plays a very important role in many essential functions of life. Several [FeS] biogenesis systems have been discovered, such as the NIF (nitrogen fixation), SUF (mobilisation of sulfur) and ISC (iron–sulfur cluster) systems in bacteria, and the ISC‐like and CIA (cytosolic iron–sulfur protein assembly) systems in yeast. Experimental evidence has revealed that SUF and ISC in bacteria communicate with each other partly through IscR to coordinate the utilisation of iron and cysteine. The ISC‐like system in yeast is localised to the mitochondria, while the ISC‐dependent CIA system is localised to the cytosol; this suggests a possible role for the ISC mitochondrial export machinery in mediating crosstalk between the two systems. Based on genetic analysis, the model plant Arabidopsis thaliana contains three [FeS] biogenesis systems similar to SUF, ISC and CIA named AtSUF, AtISC and AtCIA. Possible communication between these three systems has been proposed.
Single or multivessel percutaneous coronary intervention in ST‐elevation myocardial infarction patients
Authors: Varani Elisabetta , Balducelli Marco , Aquilina Matteo , Vecchi Giuseppe , Hussien Mohamed Naseem , Frassineti Valeria , Maresta Aleardo 
Published: September 2008

AbstractObjectives: To evaluate clinical results of percutaneous coronary intervention (PCI) in ST‐elevation myocardial infarction (STEMI) in patients with multivessel disease (MVD), in relation to single or multivessel (MV)‐PCI and to patients with single vessel disease (SVD). Methods: Patients treated with PCI in the setting of <24 hr STEMI in the years 2004–2007 were considered. Results: Seven hundred forty‐five primary PCI, 346 (46%) in patients with SVD and 399 (54%) in patients with MVD were performed. Among MVD patients, 156 (39%) had infarct related artery (IRA)‐only treatment and 243 had MV‐PCI: 147 (37%) in a single session, 48 (12%) within 24 hr, and 48 (12%) predischarge. Revascularization was complete in 46% of MVD patients. At a median follow‐up of 597 days, mortality was 6.3% in SVD and 12% in MVD (P = 0.007), new revascularization 2.9% and 9%, respectively (P < 0.001). Thirty‐day mortality was 2.4% in SVD and 6.7% in MVD (P = 0.006). After exclusion of patients with cardiogenic shock or pulmonary oedema, more frequent in the MV‐PCI in single session group (P = 0.006), 30‐day mortality was SVD 1.3%, IRA‐only 6.3%, MV‐PCI 2.8% (P = 0.023), without differences if in a single (3.3%) or in staged session (2.2%). By multivariate analysis, female sex, anterior STEMI, cardiogenic shock, MVD, and procedural failure were independent predictors of 30‐day mortality. Conclusions: STEMI patients with MVD have a worse prognosis than those with SVD. MV‐PCI in patients without hemodynamic compromise yields good short‐term results, even if performed very early, with a 30‐day mortality in between that of SVD patients and that of MVD patients with IRA‐only treatment. © 2008 Wiley‐Liss, Inc.
Treatment of ostial lesions using the Szabo technique: A case series
Authors: Applegate Robert J. , Davis Jonathan M. , Leonard Joshua C. 
Published: September 2008

AbstractWe present a series of 13 cases of stent treatment of a variety of ostial lesions including aortoostial, subclavian‐internal mammary artery, and coronary artery bifurcation disease using the double‐wire Szabo technique. We discuss relevant technical issues using this technique as well as potential advantages and disadvantages. © 2008 Wiley‐Liss, Inc.
Distribution and determinants of myocardial perfusion grade following late mechanical recanalization of occluded infarct‐related arteries postmyocardial infarction: A report from the occluded artery trial
Authors: Jorapur Vinod , Steigen Terje K. , Buller Christopher E. , Dẑavík Vladimír , Webb John G. , Strauss Bradley H. , Yeoh Eunice E.S. , Kurray Peter , Sokalski Leszek , Machado Mauricio C. , Kronsberg Shari S. , Lamas Gervasio A. , Hochman Judith S. , Mancini G.B. John 
Published: September 2008

AbstractObjective: To evaluate the distribution and determinants of myocardial perfusion grade (MPG) following late recanalization of persistently occluded infarct‐related arteries (IRA). Background: MPG reflects microvascular integrity. It is an independent prognostic factor following myocardial infarction, but has been studied mainly in the setting of early reperfusion. The occluded artery trial (OAT) enrolled stable patients with persistently occluded IRAs beyond 24 hr and up to 28 days post‐MI. Methods: Myocardial blush was assessed using TIMI MPG grading in 261 patients with TIMI 3 epicardial flow following IRA PCI. Patients demonstrating impaired (0–1) versus preserved (2–3) MPG were compared with regard to baseline clinical and pre‐PCI angiographic characteristics. Results: Impaired MPG was observed in 60 of 261 patients (23%). By univariate analysis, impaired MPG was associated with failed fibrinolytic therapy, higher heart rate, lower systolic blood pressure, lower ejection fraction, LAD occlusion, absence of collaterals (P < 0.01) and ST elevation MI, lower diastolic blood pressure, and higher systolic sphericity index (P < 0.05). By multivariable analysis, higher heart rate, LAD occlusion, absence of collaterals and higher systolic sphericity index (P < 0.01), and lower systolic blood pressure (P < 0.05) were independently associated with impaired MPG. Conclusion: Preserved microvascular integrity was present in a high proportion of patients following late recanalization of occluded IRAs post‐MI. Presence of collaterals was independently associated with preserved MPG and likely accounted for the high frequency of preserved myocardial perfusion in this clinical setting. Impaired MPG was associated with baseline clinical and angiographic features consistent with larger infarct size. © 2008 Wiley‐Liss, Inc.
Perceived family history risk and symptomatic diagnosis of prostate cancer
Authors: Spain Pamela , Carpenter William R. , Talcott James A. , Clark Jack A. , Do Young Kyung , Hamilton Robert J. , Galanko Joseph A. , Jackman Anne , Godley Paul A. 
Published: September 2008

AbstractBACKGROUND.Prostate cancer (PrCA) is the most common cancer and the second leading cause of cancer death among US men. African American (AA) men remain at significantly greater risk of PrCA diagnosis and mortality than other men. Many factors contribute to the experienced disparities.METHODS.Guided by the Health Belief Model, the authors surveyed a population of AA and Caucasian men newly diagnosed with PrCA to describe racial differences in perceived risk of PrCA and to examine whether 1) perceived high risk predicts greater personal responsibility for prostate care; and 2) greater personal responsibility for prostate care predicts earlier, presymptomatic diagnosis. Multivariate general linear modeling was performed.RESULTS.The authors found that men with a PrCA family history appreciated their increased risk, but AA men with a family history were less likely to appreciate their increased risk. Nevertheless, neither reporting a PrCA family history nor perceived increased risk significantly predicted screening and preventive behaviors. Furthermore, higher physician trust predicted increased likelihood to have regular prostate exams and screening, indicating that the racial differences in seeking prostate care may be mediated through physician trust. Expressed personal responsibility for screening and more frequent preventive behaviors were associated with more frequent screening diagnoses, fewer symptomatic diagnoses, and less frequent advanced cancers.CONCLUSIONS.Together, these results indicate that appreciating greater risk for PrCA is not sufficient to ensure that men will intend, or be able, to act. Increased trust in physicians may be a useful, central marker that efforts to reduce disparities in access to medical care are succeeding. Cancer 2008. © 2008 American Cancer Society.
A scheme for imposing constraints and improving conditioning of structural stiffness matrices
Authors: Martín F. , Benavent‐Climent A. , Gallego R. 
Published: September 2008

AbstractThis paper presents a scheme for incorporating kinematic constraints (rod constraint, diaphragm constraint) in beam‐type finite element models. The formulation employs minimization using Lagrange multipliers and does not require the arrangement of the coefficient matrix. Unlike the classical formulation—which imposes the constraints after assembling the global stiffness matrix of the structure—in the proposed scheme the constraints are applied twice: first to the stiffness matrix of the individual elements before assembly and then to the global stiffness matrix of the structure after assembly. As a result, the condition number of the coefficient matrix is remarkably reduced. The validity of the proposed scheme is demonstrated through numerical examples. Copyright © 2008 John Wiley & Sons, Ltd.
A Phenomenological Probe Model of Fast Ion Measurement Using a Hybrid Directional Probe
Authors: Nagaoka K. , Isobe M. , Osakabe M. , Watanabe K. Y. , Takeiri Y. , CHS experimental group  
Published: September 2008

AbstractA phenomenological probe model was developed for quantitative fast‐ion‐measurement using a hybrid directional probe (HDP), which is a directional probe to measure ion current and heat flux at the same position. The secondary electrons due to fast‐ion‐injection onto the probe surface enhances the ion‐saturation‐current, thus a thermal probe method was required for quantitative measurement of fast ions. The model gives a simple expression of the secondary electron yield as a function of ion currents and heat fluxes measured by the HDP, and can determine the net fast‐ion‐current without the calibrations of the thermal probe method. The model was applied to the experimental results of fast‐ion‐measurements using a HDP in CHS, and the secondary electron yield obtained by the model agrees with the calibration results of the HDP. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Developmental biology of pterobranch hemichordates: History and perspectives
Authors: Sato Atsuko , Bishop John D.D. , Holland Peter W.H. 
Published: September 2008

AbstractHemichordates, like echinoderms and chordates, are deuterostomes, and study of their developmental biology could shed light on chordate origins. To date, molecular developmental studies in hemichordates have been confined to the enteropneusts or acorn worms. Here, we introduce the developmental biology of the other group of hemichordate, the pterobranchs. Pterobranchs generally live in cold, deep waters; this has hampered studies of this group. However, about 40 years ago, the colonial pterobranchs Rhabdopleura compacta and R. normani were discovered from shallow water, which has facilitated their study. Using Rhabdopleura compacta from south‐west England, we have initiated molecular developmental studies in pterobranchs. Here, we outline methods for collecting adults, larvae, and embryos and demonstrate culturing of larvae under laboratory conditions. Given that the larval and adult forms differ from enteropneusts, we suggest that molecular developmental studies of pterobranchs may offer new insights into chordate origins. genesis 46:587–591, 2008. © 2008 Wiley‐Liss, Inc.
Synthesis and Characterisation of Two New Iron(II) Spin‐Crossover Complexes with N4O2 Coordination Spheres – Optimizing Preconditions for Cooperative Interactions
Authors: Weber Birgit , Kaps Eike S. , Desplanches Cedric , Létard Jean‐François , Achterhold Klaus , Parak Fritz G. 
Published: September 2008

AbstractTwo new spin‐crossover complexes, [FeL1(phpy)2] (1) and [FeL2(phpy)2](phpy) (2), with L1 and L2 being tetradentate N2O22–‐coordinating Schiff‐base‐like ligands {L1 = (E,E)‐[diethyl 2,2′‐[1,2‐phenylenebis(iminomethylidyne)]bis(3‐oxobutanoato)(2–)‐N,N′,O3,O3′], L2 = [(3,3′)‐[1,2‐phenylenebis(iminomethylidyne)]bis(2,4‐pentanedionato)(2–)‐N,N′,O2,O2′]and phpy = 4‐phenylpyridine} have been investigated using temperature‐dependent susceptibility and photomagnetic measurements, as well as Mössbauer spectroscopy and X‐ray structure analysis. Compound 1 shows a cooperative spin transition with a thermal hysteresis loop approximately 4 K wide (T1/2↓ = 232 K and T1/2↑ = 236 K). The spin transition of 2 is gradual with T1/2 ≈ 290 K. Results from X‐ray structure analysis indicate that the cooperative interactions are due to elastic interactions with several intense C–C contacts in the case of 1. The change of the spin state at the iron centre is accompanied by a change of the O–Fe–O angle, the so‐called bite of the equatorial ligand, from 107° in the high‐spin state to 89° in the low‐spin state. Reflectivity measurements of 1 indicate that the Light‐Induced Excited Spin State Trapping (LIESST) effect occurs at the sample surface at low temperatures. In the bulk solid, photomagnetic properties with a photoexcitation level of 30 % and a T(LIESST) value of 41 K are observed using a SQUID magnetometer. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
cis, trans – or Both: Steric Bulk Determines Coordination Mode of Dimeric Palladium Complexes with Bridging Pyridine‐Phosphane Ligands
Authors: Flapper Jitte , Wormald Philip , Lutz Martin , Spek Anthony L. , van Leeuwen Piet W. N. M. , Elsevier Cornelis J. , Kamer Paul C. J. 
Published: September 2008

AbstractThe coordination mode in a metal complex is critically dependent on the ligands surrounding the metal, on the precursors used, and on the conditions during synthesis. Our goal was to obtain palladium compounds with pyridine‐phosphane ligands for catalysis. Therefore, we synthesized ligands 1a–d, which differ in the bulky aryl substituent at the pyridyl moiety. The palladium complexes 6a–d of these ligands are insoluble and have been characterized by various techniques, including solid‐state NMR and (for 6a, b, and d) single‐crystal X‐ray diffraction, showing that bimetallic complexes are formed in which two ligands span two palladium centers. The configuration around these centers is determined by the steric bulk of the ligand. In complexes 6c,d, with the ligands bearing the largest steric groups, both centers have a trans configuration of the methyl and chloride anions. With intermediately sized pyridyl substituents, complex 6b is formed, having one cis surrounded and one trans‐surrounded palladium center in the molecule. This kind of complexation has not been observed before. With the least bulky ligand, complex 6a is formed. Depending on the synthetic conditions employed, the methyl and the chloride in this complex can be in a cis configuration at both palladium atoms, or show the unique cis‐trans coordination.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Preparation, Structure Determination, and Electrochemical Properties of Bis{[1,4,8,11, 15,18,22,25‐octaethyl‐2,3,9,10,16,17,23,24‐octakis(methylthio)phthalocyaninato]titanium(IV)} Benzene‐1,2,4,5‐tetrathiolate
Authors: Kimura Takeshi , Kumasaka Jun , Namauo Toshiharu 
Published: September 2008

Abstract4,5‐Bis(methylthio)phthalonitrile 2 was prepared from 2,3,5,6‐tetrabromodiethylbenzene in four steps. Tetramerization and cyclization of phthalonitrile 2 with lithium n‐pentoxide at 115 °C produced octaethyl‐octakis(methylthio)phthalocyanine (3). A titanium atom was introduced into thephthalocyanine 3 by treatment with titanium(IV) tetrabutoxide in DMF at 130 °C to give the corresponding metal complex 3‐TiO. Linking of two molecules of the phthalocyanine 3‐TiO with benzene‐1,2,4,5‐tetrathiol (BTT) produced a double‐decker‐type compound, bis{[octaethyl‐octakis(methylthio)phthalocyaninato]titanium(IV)} benzenetetrathiolate (6), in which the two phthalocyanines are connected axially through four titanium–sulfur coordination bonds. Double‐decker derivative 7 was also obtained by a similar treatment of (tetra‐tert‐butylphthalocyaninato)titanium(IV) oxide with BTT. The structures of 6 and 7 were determined by NMR, IR, UV/Vis spectroscopy and FAB mass spectrometry. Both phthalocyanine skeletons of 6 have symmetrical structures, as shown by the 1H and 13C NMR spectra. The electrochemical properties of 6 were examined by cyclic voltammetry with Ag/AgNO3 as the reference electrode.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Synthesis of Indolobenzazepinones by Application of an Isocyanide‐Based Multicomponent Reaction
Authors: Beaumont Stéphane , Retailleau Pascal , Dauban Philippe , Dodd Robert H. 
Published: September 2008

AbstractApplication of a Ugi multicomponent reaction to oxo acids 4 allows the formation of potentially antimitotic indolobenzazepinones of type 5 in good yields of up to 72 %, whereas the same transformation from the starting substrate 6 gives access to analogues of paullone with yields of up to 89 %. The reaction could be applied to a wide range of isocyanides, thereby ensuring introduction of molecular diversity at the key C‐5 position. Use of cyclohexenyl isocyanide allows post‐condensation modifications, while careful choice of the amine and the indole protecting groups proved to be important for providing the deprotected compounds necessary for biological tests. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Synthesis of L‐ and D‐4,6‐Dideoxyhexoses and 4,6‐Dideoxy‐C‐phenylglycosides from Enzyme‐Generated Products
Authors: Acetti Daniela , Brenna Elisabetta , Fuganti Claudio , Gatti Francesco G. , Malpezzi Luciana , Serra Stefano 
Published: September 2008

AbstractOptically active 1,3‐diols 1 were prepared by biocatalysed routes. The synthetic versatility of compounds 1 as chiral building blocks was shown. The oxidative cleavage of the double bond afforded a carbonyl moiety, which allowed for elongation by Grignard addition and further derivatisation to make deoxy sugars readily available. The epoxidation of the same double bond allowed the direct intramolecular opening of the epoxide ring to generate deoxy C‐phenylglycosides. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Hydrolytic Deallylation of N‐Allyl Amides Catalyzed by PdII Complexes
Authors: Ohmura Naoya , Nakamura Asami , Hamasaki Akiyuki , Tokunaga Makoto 
Published: September 2008

AbstractHydrolytic deallylation of N‐allyl amides to give amides and propanal can be achieved with PdII catalysts. The optimized catalyst consists of Pd(OCOCF3)2 and 1,3‐bis(diphenylphosphanyl)propane (DPPP). Several kinds of open‐chain N‐allyl amides and N‐allyl lactams undergo hydrolytic deallylation to give the corresponding amides and lactams in good to high yield. A mechanism which includes isomerization to enamides and subsequent hydrolysis is proposed. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)