bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis dan Perancangan Sistem Informasi Aplikasi Kost Berbasis Website Dengan Metode Pengujian UAT (User Acceptance Test)
Authors: Yoel Yoel Marcelino Pribadi , Suwitno Suwitno , Wijaya Andri 
Published: February 2025

Sistem pemesanan kost yang masih menggunakan buku (manual) seringkali tidak efisien dan kurang memadai dalam memenuhi kebutuhan pengguna. Proses yang melibatkan kunjungan fisik dan komunikasi yang tidak terstruktur membuat pengguna kesulitan dalam pemesanan kost. Selain itu, pemilik kost menghadapi tantangan dalam mengelola data penyewa kost Solusi yang di usulkan adalah pengembangan aplikasi kost berbasis website yang menyediakan platform yang efisien untuk pemesanan kost dan manajemen kost. Aplikasi ini dirancang untuk memudahkan pengguna dalam memesan kost. Di sisi lain, aplikasi ini memberikan alat manajemen yang efisien bagi pemilik kost untuk mengelola kost mereka dan berinteraksi dengan penyewa. Metode pengujian User Acceptance Test (UAT) diterapkan untuk memastika bahwa sistem memenuhi kebutuhan dan ekspetasi pengguna. Sehingga sistem kost berbasis website diperlukan. Software yang digunakan untuk merancang aplikasi ini yaitu PHP, JavaScript, MySQL, CSS dan Bootstrap Hasil dari penelitian ini menunjukkan bahwa aplikasi kost berbasis website yang dirancang dengan metode UAT mampu meningkatkan efisiensi dan kepuasan pengguna dalam pemesanan kost. Pengujian UAT mencatat aplikasi yang perlu diperbaikan, yang kemudian diimplementasikan untuk meningkatkan kinerja dan funsionalitas sistem. Secara keseluruhan, aplikasi ini berhasil menyediakan solusi yang efektif untuk tantangan yang dihadapi dalam manajemen kost.
Pengaruh Keseimbangan Kehidupan dan Lingkungan Kerja Terhadap Kepuasan Kerja Pegawai Kementerian Koordinator Pembangunan
Authors: Lestari Tri , Ibtisamah Adrin Bilqis , Damhudi Dedi 
Published: February 2025

Penelitian ini menyoroti pentingnya keseimbangan kehidupan dan lingkungan kerja terhadap kepuasan kerja pegawai Kemenko PMK, karena ketidakseimbangan kehidupan dan buruknya lingkungan kerja dapat menurunkan kepuasan kerja. Tujuan penelitian adalah memahami Pengaruh Keseimbangan Kehidupan Kerja juga Lingkungan Kerja Terhadap Kepuasan Kerja Pegawai Kemenko PMK. Metode yang digunakan adalah kuantitatif. Informasi digabungkan melalui daftar pertanyaan kepada 100 pegawai di unit biro umum dan sumber daya manusia. Sampel berjumlah 80 pegawai ditentukan menggunakan simple random sampling. Informasi diolah menggunakan SPSS versi 25. Sumber informasi mencakup informasi primer dari observasi dan daftar pertanyaan. Hasil riset mengungkapkan bahwa: Keseimbangan Kehidupan (X1) memiliki pengaruh positif siginifikan secara parsial terhadap Kepuasan Kerja Pegawai (Y) pada Kemenko PMK. 2) Lingkungan Kerja (X2) memiliki pengaruh positif siginifikan secara parsial terhadap Kepuasan Kerja Pegawai (Y) Kemenko PMK. 3.) Secara simultan, Keseimbangan Kehidupan (X1) dan Lingkungan Kerja (X2) memiliki pengaruh positif siginifikan terhadap Kepuasan Kerja Pegawai (Y) Kemenko PMK. Penelitian ini penting karena hasilnnya menunjukkan pengaruh positif dan siginifikan antara variabel independen dan dependen.
Peningkatan Cyber Security Awareness Melalui Pelatihan Edukatif Kepada Siswa Sekolah Menengah Kejuruan
Authors: Habie Khairul Fathan , Putro Aldibangun Pidekso , Yuliansyah Herman , Riadi Imam 
Published: February 2025

Perkembangan teknologi informasi dan komunikasi telah mengalami pertumbuhan yang sangat pesat. Era digital membawa banyak kemudahan dan keuntungan, mulai dari akses informasi yang cepat, komunikasi yang efisien, hingga kemudahan layanan online yang mempermudah kehidupan sehari-hari. Sejalan dengan hal tersebut era digital juga menghadirkan tantangan baru dalam hal keamanan informasi atau cyber security. Keamanan informasi menjadi semakin krusial dengan meningkatnya penggunaan teknologi digital, membuat individu, organisasi, dan institusi rentan terhadap ancaman siber seperti peretasan, pencurian data, malware, dan serangan phishing. Oleh karena itu, diperlukan pelatihan dengan tujuan untuk meningkatkan kesadaran dan pemahaman siswa SMK 1 Sedayu, tentang pentingnya kesadaran dan pemahaman cyber security. Kegiatan program pemberdayaan umat (PRODAMAT) meliputi tahap persiapan, pelaksanaan, dan evaluasi. Kegiatan PRODAMAT dilakukan dengan metode ceramah dan diskusi tanya jawab. Peningkatan pemahaman siswa diukur dengan rangkaian pre-test dan post-test. Hasil yang diperoleh dari program pemberdayaan umat menunjukkan bahwa adanya peningkatan pemahaman pada indikator kesadaran “Sangat Paham” meningkat dari 31% menjadi 52%.
ANALISIS VOLATILITY CONTAGION ANTARA MATA UANG KRIPTO, EMAS, MINYAK DAN PASAR SAHAM INDONESIA
Authors: Alpinansyah Nur , Yusuf Muhammad , Maksar Muhammad Sofian 
Published: February 2025

Penelitian ini menganalisis pengaruh volatilitas Bitcoin, emas, dan minyak terhadap volatilitas pasar saham Indonesia selama periode 2014-2024. Tujuan penelitian ini adalah untuk mengidentifikasi pengaruh volatilitas Bitcoin, emas, dan minyak terhadap volatilitas pasar saham indonesia dalam jangka pendek dan jangka panjang, untuk mengetahui apakah terdapat perbedaan signifikan dalam tingkat volatility contagion dari Bitcoin, emas, dan minyak ke volatilitas pasar saham Indonesia, serta untuk mengidentifikasi apakah volatilitas Bitcoin, emas, dan minyak memiliki arah pengaruh yang sama terhadap volatilitas pasar saham indonesia. Metode penelitian yang digunakan adalah ekonometrika dengan model DCC-GARCH dan Wavelet Coherence. Data yang digunakan adalah data harga penutupan dan return harian dari Bitcoin, emas, minya k, dan pasar saham Indonesia yang bersumber dari investing.com. Hasil analisis DCC-GARCH menunjukkan bahwa volatilitas Bitcoin memiliki pengaruh positif yang signifikan terhadap volatilitas pasar saham Indonesia, baik dalam jangka pendek maupun jangka panjang. Volatilitas Emas memiliki pengaruh negatif yang signifikan terhadap volatilitas pasar saham Indonesia dalam jangka panjang, tetapi tidak signifikan dalam jangka pendek. Volatilitas Minyak memiliki pengaruh positif yang signifikan terhadap volatilitas pasar saham Indonesia, baik dalam jangka pendek maupun jangka panjang. Hasil ini menunjukkan bahwa pasar keuangan saling terhubung dan dapat saling mempengaruhi, khususnya dalam hal volatilitas. Hasil Wavelet Coherence menunjukkan pasar saham Indonesia memiliki korelasi positif yang signifikan secara statistik dengan Bitcoin, emas, dan minyak. Ini menunjukkan bahwa pergerakan pasar saham Indonesia cenderung bergerak bersamaan dengan ketiga aset tersebut, baik dalam jangka pendek maupun jangka panjang. Hubungan sinkron antara pasar saham Indonesia dan ketiga aset tersebut terlihat terutama pada tahun 2017, 2018, dan 2019. Ini menunjukkan bahwa selama periode waktu tersebut, pergerakan pasar saham Indonesia dan aset-aset tersebut cenderung bergerak bersamaan.
Evaluating Surface Roughness of Ductile Cast Iron Machined by EDM Using Solid and Hollow Cylindrical Copper Electrodes
Authors: Mehra Rahul , Singh Harvinder , Chaubey Sujeet Kumar 
Published: February 2025

This study reports a comparative analysis to evaluate the performance of solid cylindrical and hollow cylindrical copper electrodes in terms of average surface roughness 'Ra' for machining ductile cast iron (DCI) using the electrical discharge machining (EDM) process. Experiments were conducted by varying the peak current, spark-on duration, spark-off duration, and flushing pressure according to Taguchi's L9 (43) orthogonal array experimental design matrix. Nine experiments were conducted using each tool electrode. Thus, a total of eighteen experiments were performed in this study. It was found that surface roughness increased with an increase in peak current and spark-on duration and decreased with an increase in spark-off duration and flushing pressure. Peak current and spark-on duration have a significant influence on surface roughness. Analysis of variance (ANOVA) was employed to identify substantial EDM variables and to develop a model for predicting the average surface roughness. The interaction graphs show the relationships between the considered EDM variables. Microstructural analysis of the best-finished machined surfaces was conducted using a scanning electron microscope (SEM). The SEM micrographs reveal that irregular, deeper, and non-uniform craters are formed on the DCI surface machined with the hollow cylindrical copper electrode. This comparative study concluded that the solid cylindrical copper electrode produced lower surface roughness than the hollow cylindrical copper electrode. Thus, a better surface finish of DCI can be achieved by EDM using the solid cylindrical copper electrode.
Analytical and clinical validation of a novel MeltPlus TB-NTM/RIF platform for simultaneous detection of Mycobacterium tuberculosis complex, Non-Tuberculous Mycobacteria and rifampicin resistance
Authors: Wang Zhuo , Zou Yuanwu , Wei Zihan , Bai Guanghong , Wang Xiaolin , Qu Shaoyi , Shi Jie , Jiang Yaping , Gu Cuijiao 
Published: February 2025

BackgroundRapid and accurate diagnosis of tuberculosis, particularly rifampin (RIF)-resistant tuberculosis (RR-TB) and Non-Tuberculous Mycobacteria (NTM), is essential for implementing appropriate proper therapy to benefit patients and improve TB/NTM patient management.MethodsIn this study, we developed a novel MeltPlus MTB-NTM/RIF platform, designed to simultaneously detect Mycobacterium tuberculosis complex (MTBC), NTM and RIF resistance. The platform was evaluated for its limit of detection (LOD) and specificity before clinical validation, followed by a prospective single-center study in patients with presumptive TB cases.ResultsThe calculated LOD for MTBC, NTM and RIF susceptibility was found to be 10.31 CFU/mL, 57.55 CFU/mL and 48.584 CFU/mL, respectively. The assay showed a sensitivity of 98.76% (95% CI: 96.41-99.74%) and a specificity of 94.42% (95% CI: 90.82-96.92%) for MTBC detection compared to the bacteriological TB standard. For NTM detection, the assay demonstrated a sensitivity of 91.98% (95% CI: 76.32-98.14%) and a specificity of 99.59% (95% CI: 98.54-99.95%). RIF resistance detection showed a sensitivity of 90.24% (95% CI:76.87-97.28%) and specificity of 95.98% (95% CI: 91.89-98.37%), with a high level of diagnostic agreement (Kappa: 0.8338) compared to GeneXpert. Sanger sequencing revealed that novel assay correctly classifies 98.6% of study cases as RIF resistant or susceptible, slightly higher that of GeneXpert.DiscussionThese findings indicate that the novel MeltPlus MTB-NTM/RIF platform provides a rapid and accurate method for the simultaneously detecting MTBC, NTM, and RIF resistance, making it a promising tool for clinical TB/NTM diagnosis and management, further multi-center and field studies are recommended to validate its broader applicability.
Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise
Authors: Zhu Huiying , Pan Jianchao , Wen Jianxuan , Dang Xiaojing , Chen Xiankun , Fan Yunxiang , Lu Weihui , Jiang Wei 
Published: February 2025

ObjectiveTo explore the impact of type 2 diabetes mellitus (T2DM) on exercise tolerance and fat oxidation capacity in patients with heart failure (HF).MethodsWe retrospectively analyzed 108 Chinese patients with HF who were divided into a diabetic group (T2DM group, n = 47) and a non-diabetic group (non-T2DM group, n = 61). All subjects completed cardiopulmonary exercise testing (CPX). We determined their fat oxidation (FATox) by indirect calorimetry.ResultsIn the HF patients, the peak oxygen uptake (VO2) value was 14.76 ± 3.27 ml/kg/min in the T2DM group and 17.76 ± 4.64 ml/kg/min in the non-T2DM group. After adjusting for age, sex, body mass index (BMI), log N-terminal pro-B type natriuretic peptide (log NT-proBNP), left ventricular ejection fraction (LVEF), hemoglobin, renal function, coronary heart disease and hypertension, the peak VO2 was lower in the T2DM group compared to the non-T2DM group with a mean difference (MD) of −2.0 ml/kg/min [95% confidence interval (CI), −3.18 to −0.82, P &lt; 0.01]. The VO2 at anaerobic threshold (AT VO2) was also lower in the T2DM group than in the non-T2DM group, with a MD of −1.11 ml/kg/min (95% CI −2.04 to −0.18, P &lt; 0.05). Regarding the fat oxidation capacity during CPX, the T2DM group's maximal fat oxidation (MFO) was lower than that of the non-T2DM group (0.143 ± 0.055 vs. 0.169 ± 0.061 g/min, P &lt; 0.05). In addition, the T2DM group had lower FATox at exercise intensity levels of 40% (P &lt; 0.05) and 50% (P &lt; 0.05) of peak VO2, compared to the non-T2DM group.ConclusionsT2DM is associated with a decrease in exercise tolerance and fat oxidation capacity in patients with heart failure. Thus, it could be useful to develop exercises of appropriate intensity to optimize physical and metabolic health.
The weight-adjusted-waist index predicts all-cause and cardiovascular mortality in hypertension
Authors: Zheng Yu , Nie Zixing , Zhang Yifan , Sun Tao 
Published: February 2025

BackgroundWeight-adjusted-waist (WWI) is a novel indicator of obesity that reflects the degree of central obesity in the human body.ObjectivesThe study aimed to explore the relationship between WWI and mortality in hypertensive individuals.MethodsCross-sectional data from the 2001–2018 National Health and Nutrition Examination Survey (NHANES) dataset were used in this study. The relationship between WWI and mortality was assessed using a weighted Cox proportional risk model; the nonlinear relationship was explored using restricted cubic splines. The robustness of the results was verified by subgroup and sensitivity analyses.ResultsA cohort of 11,556 people with a diagnosis of hypertension was included in this study. As a continuous variable, WWI was linked to higher rates of mortality from all-cause (HR = 1.23, 95% CI = 1.14, 1.33) and cardiovascular disease (CVD) (HR = 1.43, 95% CI = 1.23, 1.66) with hypertension in Model 3 adjusted for variables. Using WWI as a tertile categorical variable, individuals in the highest tertile had a 33% higher risk of all-cause death (HR = 1.33, 95% CI = 1.14, 1.56) and a 65% higher risk of CVD death (HR = 1.65, 95% CI = 1.19, 2.27) than individuals in the lowest tertile. According to the subgroup analysis, almost all groups showed a consistent positive correlation between WWI and mortality related to all-cause and CVD.ConclusionIn adults with hypertension, there is a positive association between WWI and all-cause and CVD mortality.
A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure control
Authors: Düsing Philip , Schirmer Stephan H. , Schäfer Sebastian , Krogmann Alexander , Sinning Jan-Malte , Werner Nikos , Bönner Florian , Sedaghat Alexander , Müller Cornelius , Eckardt Irina , Nickenig Georg , Zietzer Andreas 
Published: February 2025

BackgroundChronic coronary syndrome (CCS) leads to high morbidity and mortality despite therapeutic advances in recent decades. Several modifiable risk factors, including increased blood pressure (BP), significantly contribute to cardiovascular risk in CCS. Therefore, optimal secondary prevention includes managing BP through lifestyle changes and pharmacological therapy. The CHANGE study aimed to provide evidence for optimizing secondary prevention in CCS patients using a smartphone application.MethodsThe CHANGE-Study is a prospective, randomized, controlled trial performed in 9 centers in Germany. Patients with CCS were randomly allocated to either a control or an intervention group. The intervention group received the “Vantis | KHK und Herzinfarkt” digital health application and standard care. The control group received standard care alone. From the original cohort, subgroups of patients with systolic BP ≥140 mmHg (n = 44), ≥130 mmHg (n = 89) and diastolic BP ≥90 mmHg (n = 28) were analyzed for BP reduction after 12 weeks.ResultsIn patients with systolic BP ≥140 mmHg, the intervention group showed a reduction in systolic BP by 15.5 mmHg (± 16.7 mmHg, p = 0.0001), which was greater compared to the control group (6.0 ± 13.0 mmHg, p = 0.058). This observation was consistent in patients with systolic BP ≥130 mmHg at baseline. No significant differences between both groups were observed in diastolic BP reduction in patients with diastolic BP ≥90 mmHg.ConclusionThe CHANGE study documents that a smartphone-guided digital health application positively affects systolic BP in CCS patients. This study underlines the potential of digital interventions in cardiology to improve secondary prevention.
Association between pan-immune-inflammation value and coronary heart disease in elderly population: a cross-sectional study
Authors: Ma Ruicong , Ren Jinyi , Chen Xianmei , Li Xia , Zhao Ying , Ding Yanchun 
Published: February 2025

BackgroundSystemic inflammation, immune and nutrition status are closely linked to the occurrence and development of coronary heart disease (CHD). Pan-immune-inflammation value (PIV) is a new method for evaluating systemic inflammation and immune status. Our objective is to explore the connection between PIV and CHD especially in elderly people, as well as the diagnostic value of PIV combined with controlling nutritional status (COUNT) score for CHD.MethodsParticipants eligible for the study were sourced from NHANES data from 1999 to 2018. Logistic regression models were employed to evaluate the link between PIV and CHD. Additionally, restricted cubic spline was utilized to explore the correlations. Subgroup analysis was adopted in order to ensure the credibility of the results. The receiver operator characteristic (ROC) curve was used to explore the predictive value of PIV combined with COUNT score for CHD.Results41,713 individuals qualified for analysis. The individuals with CHD had higher levels of PIV. In the logistic regression model, PIV was positively related to CHD [Q4 vs. Q1, OR = 1.23 (1.03–1.48, P &lt; 0.001)]. Restricted cubic spline indicated a positive non-linear relationship (P for overall &lt;0.001, P for non-linear = 0.009). However, restricted cubic spline shows that this positive correlation is only significant in the elderly population aged 60 and above. Subgroup analysis shows that the relationship between PIV and CHD is more significant in the elderly population (P &lt; 0.001). The ROC curve shows that PIV has better diagnostic value for CHD than other common inflammatory indicators. Furthermore, the combination of PIV and COUNT score is superior to PIV or COUNT score.ConclusionsA positive link between PIV and CHD, especially in the elderly. The combination of PIV and COUNT score has better diagnostic value for CHD.
Edge-level multi-constranint graph pattern matching with lung cancer knowledge graph
Authors: Tu Houdie , Li Lei , Tao Zhenchao , Zhang Zan 
Published: February 2025

IntroductionTraditional Graph Pattern Matching (GPM) research mainly focuses on improving the accuracy and efficiency of complex network analysis and fast subgraph retrieval. Despite their ability to return subgraphs quickly and accurately, these methods are limited to their applications without medical data research.MethodsIn order to overcome this limitation, based on the existing research on GPM with the lung cancer knowledge graph, this paper introduces the Monte Carlo method and proposes an edge-level multi-constraint graph pattern matching algorithm TEM with lung cancer knowledge graph. Furthermore, we apply Monte Carlo method to both nodes and edges, and propose a multi-constraint hologram pattern matching algorithm THM with lung cancer knowledge graph.ResultsThe experiments have verified the effectiveness and efficiency of TEM algorithm.DiscussionThis method effectively addresses the complexity of uncertainty in lung cancer knowledge graph, and is significantly better than the existing algorithms on efficiency.
Proximity extension assay revealed novel inflammatory biomarkers for follicular development and ovarian function: a prospective controlled study combining serum and follicular fluid
Authors: Wang Chong , Feng Ying , Chen Yu , Lin Xianhua , Li Xiangjuan 
Published: February 2025

BackgroundMany components in follicular fluid (FF), such as peptide hormones, cytokines, and steroids, undergo dynamic changes during folliculogenesis and have important roles in follicular development. Because systemic inflammation has also been found to contribute to diminished ovarian reserve (DOR) in previous studies, do certain serum/FF inflammatory biomarkers affect both follicular development and ovarian function?MethodsSerum samples from the menstruation phase (n=26), serum samples from the ovulation phase (n=26), FF samples of mature oocytes (n=26), and FF samples of immature oocytes (n=10) were collected. Olink proteomic proximity extension assay (PEA) technology was used to compare the differentially expressed proteins (DEPs), and patients were divided into two subgroups—the normal ovarian reserve (NOR) group and the DOR group—for further bioinformatics analysis and verification by enzyme-linked immunosorbent assay (ELISA).ResultsIn total, 16 DEPs were detected between the mature group and the immature group (FF), and 11 DEPs were detected between the ovulation group and the menstruation group (serum). Further subdivision of the ovarian reserve subgroups revealed 22 DEPs in FF and 3 DEPs in serum. Among all four comparisons, only the expression of oncostatin M (OSM) significantly differed. The OSM signaling pathway, the IL-10 anti-inflammatory signaling pathway, and the PI3K−Akt signaling pathway are three notable pathways involved in affecting ovarian reserve capacity according to bioinformatics analysis. In addition, the concentration of estradiol on the hCG day was slightly but positively correlated with OSM (r=0.457, P=0.029). A significantly greater level of OSM (5.41 ± 2.65 vs. 3.94 ± 1.23 pg/mL, P=0.007) was detected in the serum of NOR patients via ELISA verification, and the sensitivity and specificity of ovarian reserve division were 50.00% and 83.33%, respectively.ConclusionThis study proposed that immunological changes assessed by PEA technology affect ovarian function in humans and that OSM may serve as a potential inflammatory biomarker for ovarian function in serum, thus revealing alterations in FF.
Efficacy and safety of once-weekly semaglutide monotherapy in a young subject with Prader-Willi syndrome, obesity, and type 2 diabetes: a case report
Authors: Dinoi Elisa , Daniele Giuseppe , Michelucci Angela , Baldinotti Fulvia , Campi Fabrizio , Marchetti Piero , Del Prato Stefano , Dardano Angela 
Published: February 2025

BackgroundThe treatment of obesity and type 2 diabetes (T2D) in Prader-Willi syndrome (PWS) is still a challenge. Glucagon-like peptide 1 receptor agonists (GLP-1 RA) are attractive options, since they effectively reduce weight and improve blood glucose, without increasing the risk of hypoglycemia. However, data on their use in PWS are scarce.Case descriptionIn 2019, a 27-year-old male came to our Clinic because of first appearance of severe hyperglycemia (fasting plasma glucose 22.5 mmol/L). Based on clinical presentation, PWS was suspected, and diagnosis was confirmed by genetic tests. The patient was discharged on a basal-bolus insulin therapy managed by his parents due to his cognitive impairment. In spite of COVID-19 pandemic, the patient achieved tight glycemic control (HbA1c 41 mmol/mol) with non-severe hypoglycemic events in the face of significant body weight (BW) increase (+ 13 kg vs baseline). Insulin therapy was then discontinued, and once-weekly semaglutide (up to 0,5 mg weekly) was started. At 12-month follow-up, BW dropped from 79 to 73 kg while maintaining excellent glycemic control (HbA1c 40 mmol/mol). At 24-month follow-up, glycemic control remained optimal (HbA1c 38 mmol/mol) with further BW reduction (71 kg). Neither hypoglycemia nor gastro-intestinal or psychiatric adverse events were reported.ConclusionThis case supports the potential use of semaglutide for the treatment of subjects with PWS, obesity and T2D. Ad hoc trials are needed to evaluate the long-term efficacy and tolerability in these subjects.