bluuebunny/crossref_metadata_2025_split huggingface dataset:
High dose adenosine for suboptimal myocardial reperfusion after primary PCI: A randomized placebo‐controlled pilot study
Authors: Stoel Martin G. , Marques Koen M.J. , de Cock Carel C. , Bronzwaer Jean G.F. , Birgelen Clemens von , Zijlstra Felix 
Published: November 2007

AbstractObjectives: This study was designed to investigate the influence of high dose intracoronary adenosine on persistent ST‐segment elevation after primary percutaneous coronary intervention (PCI). Background: After successful PCI for acute myocardial infarction 40–50% of patients show persistent ST‐segment elevation indicating suboptimal myocardial reperfusion. Adenosine has been studied to ameliorate reperfusion and is frequently used in a variety of doses, but there are no prospective studies to support its use for treatment of suboptimal reperfusion. Methods: We conducted a blinded, randomized, and placebo‐controlled study with high dose intracoronary adenosine in 51 patients with <70% ST‐segment resolution (STRes) after successful primary PCI. All patients were treated with stents and abciximab. Results: Immediately after adenosine, significantly more patients showed optimal (>70%) STRes compared with placebo (33% versus 9%, P < 0.05). Mean STRes was higher after adenosine (35.4% versus 23.0%, P < 0.05). In addition, TIMI frame count was significant lower (15.7 versus 30.2, P < 0.005), Myocardial Blush Grade was higher (2.7 versus 2.0, P < 0.05) and resistance index was lower in the adenosine group (0.70 versus 1.31 mm Hg per ml/min, P < 0.005). Conclusions: Intracoronary adenosine accelerates recovery of microvascular perfusion in case of persistent ST segment elevation after primary PCI. © 2007 Wiley‐Liss, Inc.
Transcatheter closure of atrial septal defect with Amplatzer® device in children aged less than 10 years old: Immediate and late follow‐up
Authors: Rossi Raul I. , Cardoso Cristiano de Oliveira , Machado Paulo Renato , Francois Lisia Galant , Horowitz Estela Suzana K. , Sarmento‐Leite Rogerio 
Published: November 2007

AbstractAims: To analyze the efficacy and follow‐up results of percutaneous closure of Atrial septal defect (ASD) with the Amplatzer® septal occluder in children aged <10 years old. Methods: Between November 1998 and September 2005, 27 patients diagnosed with ASD were treated percutaneously with an Amplatzer septal occluder. The procedure was carried out in the cathlab, under general anesthesia and with both fluoroscopy and transesophageal echocardiography guidance. Basal physical examinations and echocardiograms were performed prior to the procedure and at 30 days, 6, and 12 months of follow‐up. Survival free of symptom was estimated by Kaplan–Meier. Results: The mean age, weight, height, body mass index, and corporal surface was: 5.35 ± 2.11 years, 23.07 ± 9.43 kg, 110.55 ± 17.6 cm, 16.77 ± 2.42 kg/m2, and 1.24 ± 2.44 m2. The prevalence of septal aneurysm was 3.7% and all patients presented single secundum ASD. The mean stretched diameter by fluoroscopy and transesophageal echocardiography were 17.18 ± 6.75 mm and 16.77 ± 5.99 mm, and the prostheses sizes were 18.83 ± 6.98 mm, ranging from 10 to 30 mm. The systolic and diastolic pulmonary pressures were 25.26 ± 5.97 mm Hg and 13.38 ± 3.40 mm Hg, respectively. The procedure time was 82.92 ± 29.14 min and the hospital stay was 2.20 ± 0.26 days. Clinical and echocardiography follow‐ups were performed within 11.59 ± 4.42 months and all devices were in the correct position with no residual shunt. Right ventricular diameter decreased from 19.38 ± 5.23mm to 11.38 ± 11.92 (P 0.001). No major complications or deaths occurred; two patients had a hematoma at the vascular access. Conclusion: Secundum atrial septal defect closure can be safely and successfully performed with the Amplatzer septal occluder in children younger than 10 years old. © 2008 Wiley‐Liss, Inc.
Synthesis of Nanometer‐Scale Porphyrin Wheels of Variable Size
Authors: Hori Takaaki , Peng Xiaobin , Aratani Naoki , Takagi Akihiko , Matsumoto Takuya , Kawai Tomoji , Yoon Zin Seok , Yoon Min‐Chul , Yang Jaesung , Kim Dongho , Osuka Atsuhiro 
Published: November 2007

AbstractStarting from 1,3‐phenylene linked diporphyrin zinc(II) complex 2ZA, repeated stepwise AgI‐promoted coupling reactions provided linear oligomers from 2nZA up to 128ZA. Of these zigzag shaped porphyrin arrays, the AgI‐promoted intramolecular cyclization reaction of 2 nZA (n=5, 6, 8, 9, 12, and 16) under dilute conditions gave the corresponding cyclic porphyrin wheels C2nZA (n=5, 6, 8, 9, 12, and 16), whereas large arrays 2nZA (n=24, 32, and 48) did not provide cyclic porphyrin products. These large discrete porphyrin arrays and wheels were fully characterized by means of 1H NMR spectroscopy, MALDI‐TOF mass spectrometry, UV/Vis absorption spectroscopy, GPC‐HPLC analysis, and the scanning tunneling microscopy (STM) technique. The STM images of C12ZA and C18ZA reveal their large circular structures. In the cyclic structures of C2nZA in solution, however, the gradual decrease in fluorescence quantum yields and fluorescence lifetimes are observed, reflecting some conformational heterogeneities. Collectively, the present work provides an important contribution to the construction of fully covalently linked large cyclic arranged porphyrin arrays with ample electronic interactions as a model of light‐harvesting antenna.
Death receptor expression is associated with poor response to chemotherapy and shorter survival in metastatic ovarian carcinoma
Authors: Dong Hiep Phuc , Kleinberg Lilach , Silins Ilvars , Flørenes Vivi Ann , Tropé Claes G. , Risberg Björn , Nesland Jahn M. , Davidson Ben 
Published: November 2007

AbstractBACKGROUND.Death receptors mediate both apoptosis and survival in cancer cells. The authors analyzed death receptor expression in metastatic ovarian carcinoma.METHODS.Viable tumor cells in ovarian carcinoma effusions (n = 95) were analyzed for DR4, DR5, Fas, TNFR1, and TNFR2 expression using flow cytometry. Results were analyzed for association with clinicopathologic parameters, chemotherapy response, and survival.RESULTS.DR4, DR5, and Fas were expressed by the majority of specimens, with less frequent expression of TNFR1 and TNFR2. DR4 (P = .005) and TNFR2 (P = .041) expression was higher in FIGO stage IV compared with stage III tumors. Effusions from patients who responded poorly to chemotherapy administered at disease recurrence had significantly higher DR4 (P = .006), DR5 (P = .01), and Fas (P = .001) expression. In univariate survival analysis, higher DR4 expression in viable cells correlated with poor overall (P = .0352) and progression‐free (P = .0411) survival. DR4 expression was found to be an independent predictor of overall (P = .008) and progression‐free (P = .003) survival.CONCLUSIONS.The authors have presented the first evidence of death receptor coexpression in ovarian carcinoma effusions. The association of death receptor expression in effusions with advanced stage, poor response to chemotherapy, and shorter survival suggests that these molecules are linked to an aggressive clinical course in metastatic ovarian carcinoma. Cancer 2008. © 2007 American Cancer Society.
QoS modeling and analysis of component‐based software systems: a stochastic approach
Authors: Xia Yunni , Wang Hanpin , Feng Wangsen , Huang Yu 
Published: November 2007

AbstractThere is a growing demand for using commercial‐off‐the‐shelf (COTS) software components to facilitate the development of software systems. Among many research topics for component‐based software, quality‐of‐service (QoS) evaluation is yet to be given the importance it deserves. In this paper, we propose a novel analytical model to evaluate the QoS of component‐based software systems. We use the component execution graph (CEG) graph model to model the architecture at the process level and the interdependence among components. The CEG graph can explicitly capture sequential, parallel, selective and iterative compositions of components. For QoS estimation, each component in the CEG model is associated with execution rate, failure rate and cost per unit time. Three metrics of the QoS are considered and analytically calculated, namely make‐span, reliability and cost. Through a case study, we show that our model is capable of modeling real‐world COTS software systems effectively. Also, Monte‐Carlo simulation in the case study indicates that analytical results are consistent with simulation and all are covered by 95% confidence intervals. We also present a sensitivity analysis technique to identify QoS bottlenecks. This paper concludes with a comparison with related work. Copyright © 2007 John Wiley & Sons, Ltd.
Anterior cingulate dysfunction in geriatric depression
Authors: Alexopoulos George S. , Gunning‐Dixon Faith M. , Latoussakis Vassilios , Kanellopoulos Dora , Murphy Christopher F. 
Published: November 2007

AbstractBackgroundAlthough several brain abnormalities have been identified in geriatric depression, their relationship to the pathophysiological mechanisms leading to the development and perpetuation of this syndrome remain unclear.MethodsThis paper reviews findings on the anterior cingulate cortex (ACC) function and on the relationship of ACC abnormalities to the clinical presentation and the course of geriatric depression in order to elucidate the pathophysiological role of ACC in this disorder.ResultsThe ACC is responsible for conflict detection and emotional evaluation of error and is connected to brain structures that regulate mood, emotional valence of thought and autonomic and visceral responses, which are functions disturbed in depression. Geriatric depression often is accompanied by abnormalities in some executive functions and has a clinical presentation consistent with ACC abnormalities. Indices of ACC dysfunction are associated with adverse outcomes of geriatric depression.ConclusionsConverging findings suggest that at least some ACC functions are abnormal in depression and these abnormalities are pathophysiologically meaningful. Indices of ACC dysfunction may be used to identify subgroups of depressed elderly patients with distinct illness course and treatment needs and serve as the theoretical background for novel treatment development. Copyright © 2007 John Wiley & Sons, Ltd.
A catchment framework for one‐dimensional models: introducing FLUSH and its application
Authors: Paydar Zahra , Gallant John 
Published: November 2007

AbstractA new modelling framework capable of incorporating detailed one‐dimensional models in a catchment context is presented which can be used to asses the hydrological implications (recharge, discharge, salt movement) of different land uses on different parts of the catchment. The modelling framework incorporates farming systems models and, thus, simulates crop and pasture production, whilst also accounting for lateral fluxes of water (surface and subsurface) and groundwater recharge and discharge.The framework was applied to Simmons Creek catchment, a subcatchment of the Billabong Creek in southern New South Wales, comprising gentle uplands and substantial low‐relief areas containing swamps. An integrated approach incorporating soil, hydrology, hydrogeology, and terrain analysis resulted in interpretation of landscape function and the necessary parameterization of the modelling framework. Current land use (crop rotation and pasture) and an alternative land use (10% trees on uphill units and pasture in the lower lying lands) were simulated to compare the relative contribution of parts of the catchment with total recharge. Comparison between current and alternative land use over 44 years of simulations indicated a decrease of mean annual drainage from 39 to 29 mm year−1 and an average reduction of the groundwater level of about 0·4 m. A more substantial decrease in water‐table depth would require targeted tree planting over larger areas. This can be investigated further with the spatial framework. Copyright © 2007 John Wiley & Sons, Ltd.
Sulindac and its metabolites induce carcinogen metabolizing enzymes in human colon cancer cells
Authors: Ciolino Henry P. , Bass Sara E. , MacDonald Christopher J. , Cheng Robert Y.S. , Yeh Grace Chao 
Published: November 2007

AbstractSulindac is a nonsteroidal antiinflammatory drug that has been demonstrated to be a potent chemopreventive agent against colorectal cancer in both human and animal models. In vivo, sulindac may be reversibly reduced to the active antiinflammatory compound, sulindac sulfide, or irreversibly oxidized to sulindac sulfone. Sulindac has also been shown to inhibit polycyclic aromatic hydrocarbon (PAH)‐induced cancer, but the molecular mechanisms of its antitumor effect remain unclear. In this study, we investigated the effects of sulindac and its metabolites on the expression of enzymes that metabolize and detoxify PAHs in 2 human colon cancer cell lines, LS180 and Caco‐2. Sulindac and sulindac sulfide induced a sustained, concentration‐dependent increase in CYP enzyme activity as well as an increase in the mRNA levels of CYP1A1, CYP1A2 and CYP1B1. Sulindac and sulindac sulfide induced the transcription of the CYP1A1 gene, as measured by the level of heterogeneous nuclear CYP1A1 RNA and verified by the use of actinomycin D as a transcription inhibitor. Chromatin immunoprecipitation assays demonstrated that sulindac and sulindac sulfide also increased the nuclear level of activated aryl hydrocarbon receptor, the transcription factor which mediates CYP expression. Additionally, sulindac and both metabolites increased the activity and mRNA expression of the carcinogen detoxification enzyme NAD(P)H:quinone oxidoreductase, as well as the expression of UDP‐glucuronosyltransferase mRNA. These results show an overall upregulation of carcinogen metabolizing enzymes in colon cancer cells treated with sulindac, sulindac sulfide and sulindac sulfone that may contribute to the established chemoprotective effects of these compounds. © 2007 Wiley‐Liss, Inc.
Confocal Raman microspectroscopy on excised human skin: uncertainties in depth profiling and mathematical correction applied to dermatological drug permeation
Authors: Tfayli A. , Piot O. , Manfait M. 
Published: November 2007

AbstractConfocal Raman microspectroscopy represents the advantage of giving structural and conformational information on samples without any destructive treatment. Recently, several studies were achieved to study the skin hydration, endogenous and exogenous molecules repartition in the skin using the confocal feature of this technique. Meanwhile, when working through a material boundary with a different refractive index, the main limitation remains the spatial precision, especially the distortion in the depth and the depth resolution. Recently, several authors described mathematical models to correct the depth and the resolution values. In this study, we combined theoretical approaches, proposed by different authors with experimental measurements to try to find out the most appropriate approach for correction. We then applied the corrections on in‐depth profiles tracking the penetration of Metronidazole, a drug produced by Galderma for rosacea treatment, through excised human skin. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Promotion of peripheral nerve growth by collagen scaffolds loaded with collagen‐targeting human nerve growth factor‐β
Authors: Sun Wenjie , Lin Hang , Chen Bing , Zhao Wenxue , Zhao Yannan , Dai Jianwu 
Published: November 2007

AbstractNerve growth factor (NGF) plays a critical role in neuronal development and regeneration. However, the lack of efficient NGF delivery system limits its clinical application. We reported that a peptide deduced from collagenase, TKKTLRT, fused with NGF‐β could develop a collagen based NGF targeting delivery system. Our results showed that this peptide could allow fused NGF‐β bind to collagen specifically. In addition, we found that the polypeptide could result in a 2.3‐fold increase in the expression level and a significant improvement of bioactivity of fused NGF‐β. In the in vivo function study, collagen membranes loaded with the collagen binding NGF enhanced the nerve growth. Thus, the targeting wound repair system could be important for the repair of peripheral nerve injury. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007
Bioactivity and cytocompatibility of silicon wafers treated by water
Authors: Niu Yaran , Liu Xuanyong , Ding Chuanxian 
Published: November 2007

AbstractA range of bioactive ceramics can induce bone‐like apatite to deposit on their surface in simulated body fluid (SBF). In this work, the silicon wafer was treated using deionized water to improve its bioactivity. The morphology and chemical composition of the treated silicon wafer was examined using Fourier transform infrared spectroscopy, atomic force microscopy and X‐ray photoelectron spectroscopy. Field emission scanning electron microscopy was used to observe the surface morphologies of silicon wafers soaked in SBF. The results indicated that a hydrated sub‐oxide film having SiOH groups formed on the surface of the silicon wafer after the water treatment. The amount of SiOH groups increased with raising the treatment temperature or prolonging the immersion time. Apatite was deposited on the surface of water‐treated silicon wafers immersed in SBF. The apatite deposition was correlated with the amount of SiOH groups. Human mesenchymal stem cells cultured on the surface of the water‐treated silicon wafers showed good adhesion and spread, indicating that the cytocompatibility of silicon wafer was enhanced by this water treatment. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007
Reactive oxygen species involved in prenylflavonoids, icariin and icaritin, initiating cardiac differentiation of mouse embryonic stem cells
Authors: Wo Yan‐bo , Zhu Dan‐yan , Hu Ying , Wang Zhi‐Qiang , Liu Jian , Lou Yi‐Jia 
Published: November 2007

AbstractThe significant promoting effects of some prenylflavonoids on cardiac differentiation of mouse embryonic stem (ES) cells via reactive oxygen species (ROS) signaling pathway were investigated. The most effective differentiation was facilitated by icariin (ICA), followed by icaritin (ICT), while desmethylicaritin (DICT) displayed the weakest but still significant inducible effect. Contrarily, DICT demonstrated the strongest anti‐oxidative activity while ICA displayed only little in vitro, which was well matched with the hydroxyl (OH) numbers and the positions in the molecular structures. Therefore, ROS signaling cascades were assumed to be involved in prenylflavonoids induced cardiomyogenesis. Treatment with ICA, intracellular ROS in embryoid bodies was rapidly elevated, which was abolished by the NADPH‐oxidase inhibitor apocynin; elimination of intracellular ROS by vitamin E or pyrrolidine dithiocarbamate (PDTC) inhibited ICA induced cardiomyogenesis; ROS‐sensitive extracellular‐regulated kinase 1, 2 (ERK1, 2) and p38 activation were further observed, the cardiomyogenesis was significantly inhibited in the presence of ERK1, 2 or p38 inhibitor U0126 or SB203580, indicating the roles of NADPH‐ROS‐MAPKs signaling cascades in prenylflavonoids induced cardiac differentiation. There was no difference in Nox4 NADPH oxidase expression between ICA and ICT treatments, however, ROS concentration in EBs after ICT administration was lower than that after ICA treatment, followed by less activation of ERK1, 2, and p38. These results revealed that the significant promoting effects of prenylflavonoids on cardiac differentiation was at least partly via ROS signaling cascades, and the facilitating abilities preferentially based on the nature of prenylflavonoids themselves, but anti‐oxidative activity determined by the OH numbers and the positions in the structures do influence the cardiomyogenesis in vitro. J. Cell. Biochem. 103: 1536–1550, 2008. © 2007 Wiley‐Liss, Inc.
Evidence of in vivo osteoinduction in adult rat bone by adeno‐Runx2 intra‐femoral delivery
Authors: Bhat Bheem M. , Robinson John A. , Coleburn Valerie E. , Zhao Weiguang , Kharode Yogendra 
Published: November 2007

AbstractThe bone marrow microenvironment provides a unique opportunity in vivo to assess the role of genes in bone remodeling. The objective of this study was to determine whether Runx2 expression is regulated by rhBMP‐2 in vivo and to examine the effect of Runx2 overexpression on bone in vivo. In the in vivo calvaria model we used, rhBMP‐2 induced Runx2 protein expression in periosteal cells while in vitro, adenovirus‐mediated Runx2 overexpression induced mineralization in mesenchymal stem cells. A single injection of adeno‐Runx2 directly into the bone marrow of the right femur in mature rats, and subsequent analysis after 3 weeks, showed a significant bone mineral density (BMD) increase (∼15%) as compared to the controls. The whole‐femur mean BMD of the active virus‐injected group was 0.193 (g/cm2) while that of the control virus‐injected group was 0.175 (g/cm2) (P < 0.05). In addition, a significant increase (36%) in trabecular BMD at the distal end of the femur was observed. These data demonstrate that directly delivering adeno‐Runx2 into bone marrow of adult rats induces osteogenesis and illustrates potential advantages of such approaches over ex vivo gene therapy protocols involving marrow cell isolation, gene transduction, and subsequent in vivo transfer. J. Cell. Biochem. 103: 1912–1924, 2007. © 2007 Wiley‐Liss, Inc.
The nonexistence of projective planes of order 12 with a collineation group of order 8
Authors: Akiyama Kenzi , Suetake Chihiro 
Published: November 2007

AbstractIn this article, we prove that there does not exist a symmetric transversal design ${\rm STD}_2[12;6]$ which admits an automorphism group of order 4 acting semiregularly on the point set and the block set. We use an orbit theorem for symmetric transversal designs to prove our result. As a corollary of the result, we prove that there is no projective plane of order 12 admitting a collineation group of order 8. © 2007 Wiley Periodicals, Inc. J Combin Designs 16: 411–430, 2008
Pebbling and optimal pebbling in graphs
Authors: Bunde David P. , Chambers Erin W. , Cranston Daniel , Milans Kevin , West Douglas B. 
Published: November 2007

AbstractGiven a distribution of pebbles on the vertices of a graph G, a pebbling move takes two pebbles from one vertex and puts one on a neighboring vertex. The pebbling number Π(G) is the least k such that for every distribution of k pebbles and every vertex r, a pebble can be moved to r. The optimal pebbling number ΠOPT(G) is the least k such that some distribution of k pebbles permits reaching each vertex.Using new tools (such as the “Squishing” and “Smoothing” Lemmas), we give short proofs of prior results on these parameters for paths, cycles, trees, and hypercubes, a new linear‐time algorithm for computing Π(G) on trees, and new results on ΠOPT(G). If G is connected and has n vertices, then $\Pi_{\rm OPT}(G)\le \lceil{2n/3}\rceil$ (sharp for paths and cycles). Let an,k be the maximum of ΠOPT(G) when G is a connected n‐vertex graph with δ(G) ≥ k. Always $2 \lceil{n \over {k+1}}\rceil \le a_{{n},k}\le 4 \lceil{n \over {k+1}}\rceil$, with a better lower bound when k is a nontrivial multiple of 3. Better upper bounds hold for n‐vertex graphs with minimum degree k having large girth; a special case is $\Pi_{{\rm OPT}}({G})\le {16}{n}/{({k}^{2}+{17})}$ when G has girth at least 5 and k ≥ 4. Finally, we compute ΠOPT(G) in special families such as prisms and Möbius ladders. © 2007 Wiley Periodicals, Inc. J Graph Theory 57: 215–238, 2008