bluuebunny/crossref_metadata_2025_split huggingface dataset:
What is the amniotomy effect on non stress test in patients meconium stained amniotic fluid?
Authors: Buyuk Gul Nihal , Kahyaoglu Serkan , Esgin Merve Didem , Tutkun Ceren , Kose Caner , Ustun Yaprak 
Published: February 2025

Objective: Meconium stained amniotic fluid is a frequently encountered situation, it can really disturb an obstetrician, as it increases the rates of neonatal morbidity and mortality and it is difficult to prevent meconium passage in utero. Noninvasive tests are needed to predict the meconium staining of the amnion fluid without making amniotomy or making a fetal invasive procedure. Non stress test is a commonly used method to determine the status of intrapartum fetal wellbeing. The purpose of this study was to predict fetal meconium release during labor by examining the fetal heart rate traces without performing an amniotomy procedure.
Materials and Methods: A total of 280 patients who have been diagnosed with active labor were included in the study. 140 of them demonstrated meconium stained fluid and 140 of them clear amniotic fluid. The patients’ labor courses have been watched and non-stress test results have been recorded besides obstetric outcomes.
Results: Non-stress tests performed before amniotomy; 52 (37.1%) of the non-stress tests in the meconium group were non-reactivated, whereas in the control group this count was 19 (13.5%) before amniotomy. When we accepted the deceleration entity as fetal distress; fetal distress was seen in 62(44.3%) of the patients in the meconium group and in 21(15.1%) of the patients in the control group.
Conclusion: In the presence of non-reactive non stress test pattern; we should be suspicious of meconium-stained amniotic fluid. In this case, caution should be taken in terms of fetal distress.
Sexual abuse and accepting attitudes towards intimate partner rape in Uganda
Authors: Nakyazze Brendah , Österman Karin , Björkqvist Kaj 
Published: February 2025

Objective: The aim was to study sexual abuse, accepting attitudes towards intimate partner rape and psychological concomitants in intimate partner relationships in Uganda.
Method: A questionnaire was completed by 315 respondents (174 females and 141 males). The mean age for females was 31.7 years (SD = 10.3) and 33.6 (SD = 12.4) for males.
Results: Females scored significantly higher than males on victimisation from aggression due to denial of sex, victimisation from sexual abuse, and psychological concomitants of intimate partner rape. The acceptance rate for rape in intimate relationships was high, only one percent among females and two percent among males reported zero tolerance. Victimisation from sexual abuse as well as psychological concomitants of intimate partner rape were significantly higher among respondents who had completed only primary school compared to those with a higher education. Accepting attitudes towards rape in intimate relationships were positively correlated with age, no sex differences were found. Respondents with higher educational levels reported significantly lower levels of acceptance of intimate partner rape. For females, but not for males, accepting attitudes correlated positively with both victimisation and psychological concomitants.
Conclusions: Victimisation from sexual abuse, psychological concomitants and accepting attitudes towards intimate partner rape were all related to low educational level. Reasons for the high levels of accepting attitudes towards intimate partner rape especially among female victims are discussed.
Developing Hemophagocytic Syndrome during the transformation of Chronic Lymphocytic Leukemia: Case reports of t(7;14), t(14;19) and deletion of 17 p
Authors: Tiryaki Tarik Onur , Genc Sezen , Ozan Gulcin Bagatir , Cefle Kivanc , Yegen Gulcin , Dogan Oner , Nalcaci Meliha , Palandüz Şükrü 
Published: February 2025

Objective: Chronic lymphocytic Leukemia (CLL) is the most common form of leukemia in adults. Clinical findings may broad range vary. Detecting some deletions using the FISH method may help us to foresee the progression of the disease and to choose a better treatment method in healing the patient.
Case: In this case report, we will present you a CLL patient with t(7;14), t(14;19) and 17p deletions, which are known for bad prognosis, developing autoimmune hemolytic anemia which is refractor to the treatment. This patient unfortunately died due to a clinical form of hemophagocytic syndrome including prolymphocytic transformation.
Evaluation of the relationship between serum 25-hydroxyvitamin D levels and extended period of leg cramps in pregnant women
Authors: Karli Pervin 
Published: February 2025

Objective: At least one-third of pregnant women suffer from leg cramps. While the cause of these leg cramps is not fully understood, it starts during the third trimester, likely due to pregnancy-related physiological changes. The relation of serum 25-hydroxyvitamin D [25(OH)D] levels and leg cramps has been evaluate in this research.
Methods: The study included 95 pregnant patients who visited our gynecology and obstetrics outpatient clinic in January 2017 during weeks 24–39 of their pregnancies. Demographic characteristics, vitamin supplement use, and other factors that might have affected the 25(OH)D levels of the participating pregnant women were recorded.
Results: A statistically significant difference (p<0.0001) was found in the serum 25(OH)D levels between the patients who did and did not use supplemental 25(OH)D. A statistically significant difference was found in the groups of pregnant women regarding 25(OH)D levels and weight 69.60 ± 2.43 ng/dl among the patients who did not use supplemental 25(OH)D compared to 77.69 ± 2.20 ng/dl for those who did; p < 0.0162). There was no significant difference between the 25(OH)D serum levels and the number of cramps. A significant difference was found between the intensity and duration of the cramps and the number and duration of the cramps (p < 0.029 and p < 0.0001, respectively).
Conclusion: The use of supplemental 25(OH)D did not have a statistically significant effect on the occurrence of pregnancy-related leg cramps. The 25(OH)D levels were higher in the that supplemental 25(OH)D used group. A significant difference was found between the pregnant women’s weight and the occurrence of leg cramps (p < 0.0162). Vitamin D supplements may be used to prevent long period leg cramps for pregnant woman’s.
The effect of emotional intelligence on anger management among anesthesiologists, surgeons and internal medicine physicians
Authors: Sen Bulent , Sen Selda , Kurum Simge Alkut , Omurlu Imran Kurt 
Published: February 2025

Objective: Anger management among health professionals can lead to chaos in the hospital or operating room if administered poorly. Aim of the study is to investigate the effect of emotional intelligence level on anger control in physicians.
Material and Methods: Emotional intelligence (Reuven Bar-On) and anger control questionnaire (Spielberger) were performed on the voluntary physicians.
Results: The 188 voluntary physicians (internal medicine physicians n= 67, surgeons n= 64, anesthesiologists n= 57) were included in the study. Emotional intelligence and continuous anger scales did not differ between the three groups whereas the scores of external anger in surgeons and internal anger (repressed anger) in anesthesiologists were higher. Stress endurance in the surgical group, problem-solving and empathy in anesthesiologists and social responsibility in the internal physicians group were prominent. A positive correlation was observed between emotional intelligence and age, hobbies, physical activity and anger control, while there was negative correlation with external anger scores. Total group was divided into two groups in terms of age. In the group over 35 years old, the scores of continuous anger and external anger were lower, whereas the emotional intelligence was higher.
Conclusion: We conclude that emotional intelligence is effective in anger management. Higher age, more occupational experience, being more activities and having hobbies may be associated with better emotional intelligence and anger management in anesthesiologists and surgeons under stress in the operating room and internal physicians as well.
Neuroprotective Effects of Boric Acid against Fluoride Toxicity on Rat Synaptosomes
Authors: Hacıoğlu Ceyhan , Kar Fatih , Senturk Hakan , Kanbak Gungor 
Published: February 2025

Objective: Fluoride toxicity primarily contributes to the production of reactive oxygen and nitrogen derivatives, trigger the cell death pathways by causing lipid peroxidation and DNA damage. Boric acid (BA) contributes to preservation of membrane integrity and function and maintenance of redox balance due to its high affinity to some metabolites in the organism. The aim of this study was to investigate the protective effect of BA on neurodegenerative processes against the toxic effects of sodium fluoride (NaF) administered at different doses on rat brain synaptosomes.
Material and Methods: Synaptosomes obtained from the rat frontal cortex were administered at different doses of sodium fluoride (NaF) to determine the most toxic dose of NaF. Determined toxic dose of NaF for synaptosomes and BA concentrations were administered in vitro at 37°C for 30min and then the parameters of malondialdehyde (MDA) level, superoxide dismutase (SOD) activity, Na/K ATPase activity and DNA fragmentation value were measured spectrophotometrically.
Results: There was a statistically significant difference between measured parameters, when the 80mg/L NaF group was compared with the control group. We found that 10 and 25 mM BA treatment provided a significant improvement in MDA, SOD, Na/K ATPase and DNA fragmentation compared to the 80mg/L NaF group. The 5 mM BA concentration was not found effective dose according to other doses.
Conclusion: In conclusion, BA has potential for neuroprotective effects against cellular damage caused by NaF. The results suggest that the BA can be a neuroprotective therapeutic agent for fluoride toxicity.
Henoch Schönlein Purpura in children: Clinical features and risk factors for renal involvement
Authors: Fedakar Atiye 
Published: February 2025

Objective: This study aimed to evaluate the clinical and laboratory features of children diagnosed with Henoch Schönlein purpura (HSP), risk factors of renal involvement and their effect on prognosis.
Methods: A total of 80 pediatric HSP patients (44 males and 36 females) between ages 2 to 13 (average age 7.68±3.09) admitted to the Pediatrics Clinic and follow-up cases from the Pediatric Rheumatology and Nephrology Clinic of the Istanbul Medeniyet University, Göztepe Training and Research Hospital, between April 1998 and June 2003 were enrolled for the study. In order to precisely evaluate glomerular and tubular function, urinary β 2 microglobulin, microalbumin and tubular reabsorption of phosphorus (TRP) were determined.
Results: A retrospective evaluation of the HSP patients showed that 26 (32.5%) had symptoms of renal impairment. In terms of renal function, 20 (25%) out of the 54 asymptomatic children initially subjected to routine renal tests had renal involvement. In terms of age, there was a significant difference (p < 0.016) in developing renal involvement between patients above 5 years old and those younger than 5 years.
Conclusion: It was therefore suggested that long-term follow-ups in addition to examinations such as routine kidney function tests, tubular reabsorption of phosphate (TRP) and microalbumin levels should be conducted in order to detect the early phase of renal damage.
Pseudobulbar affect prevalence in Turkish multiple sclerosis patients
Authors: Demir Serkan , Koskderelioglu Asli , Karaoglan Mustafa , Gedizlioglu Muhtesem , Togrol Rifat Erdem 
Published: February 2025

Objective: Pseudobulbar affect (PBA) is characterized by uncontrolled crying or laughing attacks which are usually socially inappropriate. The estimated prevalence in patients with multiple sclerosis (MS) ranges from 10% to 46.2%. We conducted a cross-sectional study to evaluate the prevalence of PBA in the Turkish MS population. Also, we aimed to estimate whether there was gender preference or coexistent depression.
Material and Methods: We used the Center for Neurologic Study - Lability Scale (CNS-LS) for this study. We included patients who were followed up at our outpatient clinic of Sultan Abdulhamid Han Education and Research Hospital with definitive diagnosis of MS at least for one year. The total number of patients was 328. 60.4% were women (198/328) and 39.6% were men (130/328). Descriptive statistical methods, student t test and chi-square tests were used for the analysis by using SPSS. The prevalence of PBA in the Turkish MS population was 39.6%. 34.6% of the men with MS had PBA; whereas 42.9% of the women with MS had PBA (p=0.132). The incidence of PBA was 48.1% in MS patients with depression and 38% in those without depression (p=0.175).
Results: As a result of t-test applied it was understood that depression did not significantly contribute to PBA frequency. The average depression test score was 13.28 in non-depressed, 17.85 in others. Furthermore, there was a difference between pathological laughing and pathological crying (p<0.05). Also, in both gender pathological laughing laughter was more and the difference was significant (p<0.05).
Conclusion: Our study revealed the increased frequency of PBA in MS patients. Gender and having depression did not make a significant difference on the PBA prevalence. However, depression significantly increased PBA test scores
The effects of TGN-020 on penicillin induced epileptiform activity in rats
Authors: Akyuz Enes , Pala Mukaddes , Kozan Ramazan , Kose Hayrullah 
Published: February 2025

Objective: Aquaporin-4 (AQP-4) is a water channel protein which is the most abundant aquaporin isoform in the brain. Recent studies indicate the relationship between AQP-4 with epileptogenesis. Therefore, we examined the potential effect of the AQP-4 inhibitor TGN-020 on penicillin-induced epileptiform activity in rats.
Material and Method: Epileptiform activity was induced by intracortical (i.c.) administration of penicillin (200 IU, 1 μl). TGN-020, at doses of 25 µg, 50 µg, 100 µg and 200 µg, was administered by intracerebroventricular (i.c.v.) 30 minutes after penicillin injection. The epileptiform activity was verified by electrocorticographic (ECoG) recordings. Twenty four hours later, animals are decapitated for the collection of blood samples and brain tissue.
Results: The dose of 100 µg TGN-020 decreased the mean spike frequency of epileptiform activity in the 30 min after the injection without changing the amplitude (p < 0.05). Serum neuropeptide Y level was up-regulated by 25 µg TGN-020 in comparison with the other groups (p<0.001). Plasma levels of calcineurin in the 50 µg dose of TGN-020 were lower than 25 µg and 200 µg doses of TGN-020(p<0.01). Enzymatic ativity of glutathione peroxidase (GPx-1) in brain tissue was higher in the penicillin and 25 µg TGN-020 group compared with the sham group (p < 0.05).
Conclusion: Given all these data, the anticonvulsant effect of TGN-020 which is aquaporin-4 water channel inhibitor in the brain has been studied extensively for the first time in an experimental model of epilepsy. Inhibition of AQP-4 might be useful in the treatment of epilepsy in future.
Family history in chronic psychotic disorders
Authors: Şahin Şengül , Elboğa Gülçin 
Published: February 2025

Objective: Psychosis is a set of symptoms that consist of delusions, hallucinations an thought disorders. In DSM 5, psychoses were collected under the title of schizophrenia spectrum and other psychotic disorders. The aim of this study was to investigate the prevalence of a family history of psychiatric disorders in patients with chronic psychosis and to examine the groups of these psychiatric disorders.
Material and Methods: A total of 282 patients with chronic psychosis, defined by DSM- 5diagnostic criteria, were included in this study. Sociodemographic parameters and family history of chronic psychosis patients were retrospectively reviewed.
Results: The mean age of the patients was 41.3 years, the mean age of onset of the disease was 22.8 years and the mean number of hospitalizations was 5.78 years. Patient group consisted of 94 (33.3%) males and 188 (66.7%) females. 48.6% (137/282) of patients with chronic psychosis had a history of psychiatric disorder in their first-degree relatives. In the diagnostic groups, there were 1.8% (5/282) schizoaffective disorder, 18.4% (52/282) schizophrenia, 6% (17/282) bipolar disorder, 5.7% (16/232) major depression, 13% , 8 (39/282) unspecified schizophrenia spectrum and other psychotic disorder, 2.5% (7/282) mental retardation, 0.4% (1/232) obsessive-compulsive disorder family history.
Conclusion: This study provides a platform for future studies to contribute to the development of early intervention and prevention approaches in populations at risk for further clarification of the role of family history in individuals with a family history
Determination of platelet count and platelet indices in canine parvoviral enteritit
Authors: Koenhemsi Lora 
Published: February 2025

Objective: Canine parvoviruses (CPV) are DNA viruses with symptoms that can cause death in young dogs. The aim of this study was to characterize platelet count and platelet indices at the time of diagnosis of CPV and to assess the correlation between PLT, RBC, and WBC with platelet indices.
Materials and Methods: The current study included 26 dogs with Parvo and 11 healthy dogs.
Results: When the haemogram values were compared statistically, no difference was observed. Positive correlation was found between Mean platelet volume (MPV) and Platelet distribution width (PDW).
Conclusions: Platelet and platelet indices may not be important in the diagnosis and prognosis of CPV. Further studies on this issue are of importance in terms of understanding the PLT indices in viral disease in animals.
Fine needle aspiration cytology (FNAC) of cystic soft tissue lesions and end tissue metamorphosis-a three year study
Authors: Thapa Ragini Thapa , Beniwal Rajveer Singh , Ganguly Prosenjit 
Published: February 2025

Objective: Superficial soft-tissue masses may be seen in clinical practice, but a systematic approach may help to achieve a definitive diagnosis or differential diagnosis for soft tissue lesions. The cystic lesions constitute a heterogeneous group with highly varied etiology, cytology and diversified histopathology. The aim of this study is to investigate the accuracy of FNAC diagnosis of varied cystic lesions of soft tissue lesions by comparing with the radiological and histopathology diagnosis.
Materials and methods: Fine needle aspirations were done using a 22-24 gauge disposable needle and a 5cc to 10 cc disposable syringe for suction. Wet-fixed smears with isopropyl alcohol were stained with hematoxylin and eosin (HxE). Dry-fixed smears were stained with Leishman Giemsa along with Papanicolaou stains (PAP) were studied for cytological details and diagnosis. The excised surgical specimen and biopsy samples of the cases were processed routinely and stained with HxE and immunohistochemistry (IHC) panel was applied.
Results: Examined cystic soft-tissue masses were found as superficial (82%) and deep (18%). Superficial lesions were categorized into mesenchymal tumors, skin appendage lesions, tumor like lesions, pseudoudo tumoural soft tissue lesions or parasitic /inflammatory lesions. Deeper lesions with cystic presentation were mostly (74%) malignant. The differential diagnosis was done according to the age of the patient, anatomic location of the lesion, salient imaging features and clinical manifestations.
Conclusion: Although the fine needle aspiration cytology of the cystic lesions, imaging characteristics of the lesions discussed are not always corresponding to the histopathologic findings what we assume, combining them with lesion location and clinical features may allow the diagnosticians to suggest a specific diagnosis in most cases.
Which of the direct acting anti-viral agents is the better drug in terms of efficacy, cost and safety, Boceprevir or Telaprevir?
Authors: Aziz Mark 
Published: February 2025

Objective: Hepatitis C virus can cause chronic hepatitis with 20-30% of those infected are developing liver cirrhosis and some developing hepatocellular carcinoma. It is a global health problem with 130-170 million people infected worldwide. The current treatment uses pegylated interferon and Ribavirin. As of 2011, two new drugs have been approved in the U.S.A and Europe, the protease inhibitors Boceprevir and Telaprevir. The aim of this structured review is to investigate which of these two new drugs is better in terms of efficacy, safety and cost. A literature search was conducted using various primary and secondary sources. A database search was conducted to find three journals for critical review.
Conclusion: The articles showed that the two drugs are equally effective and more effective than standard therapy. Boceprevir is potentially significantly cheaper. Boceprevir may also have a slightly better adverse effects profile. However, it is evident that direct clinical trials comparing the two drugs are required.
Cutaneous sporotrichosis with dermoscopic features: A case report
Authors: Acar Emine Müge , Günay Ümran , Elmas Ömer Faruk , Şirin Serpil Çorum , Kilitci Asuman 
Published: February 2025

Objective: Sporotrichosis is a fungal skin infection caused by Sporothrix schenckii. We report a 70- year-old female presenting with an erythematous nodule on her right forefinger after a rose thorn prick.
Material and Methods: The nodule was histopathologically diagnosed as sporotrichosis. Dermoscopy of the nodule revealed structureless white areas with a lobular arrangement, prominent scaling, blood spots, and polymorphous vessels including coiled, punctate and looped vessels. Dermoscopy has opened a new horizon in the diagnosis of skin infections in recent years.
Conclusion: The dermoscopic features of sporotrichosis have not yet been reported as far as we are aware. We believe that coexistence of the above features, which could be thought to be nonspecific when seen separately, may be of diagnostic significance and a helpful tool in the diagnosis of cutaneous sporotrichosis.