bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: A multicenter randomized controlled study
Authors: Ebbens Fenna A. , Georgalas Christos , Luiten Silvia , van Drunen Cornelis M. , Badia Lydia , Scadding Glenis K. , Hellings Peter W. , Jorissen Mark , Mullol Joaquim , Cardesin Alda , Bachert Claus , van Zele Thibaut P. J. , Lund Valerie J. , Fokkens W. J. 
Published: January 2009

AbstractBackground:It has been suggested that an exaggerated immune response to fungi is crucial in the pathogenesis of chronic rhinosinusitis (CRS). Based on this rationale, the use of topical antifungals (amphotericin B) has been advocated. Studies on its clinical effectiveness are, however, contradictory.Objectives:To examine the effect of nasal antifungal treatment on secreted mediators in samples of nasal lavage fluid from patients with CRS with or without nasal polyps (NP).Methods:Part two of a prospective double‐blind, placebo‐controlled multicenter clinical trial investigating the effect of 13 weeks of treatment with amphotericin B or placebo on the levels of pro‐inflammatory cytokines, chemokines and growth factors (i.e., IL‐1β, IL‐1RA, IL‐2, IL‐2R, IL‐3, IL‐4, IL‐5, IL‐6, IL‐7, IL‐8, IL‐10, IL‐12 (p40/p70 subunits), IL‐13, IL‐15, IL‐17, TNF‐α, IFN‐α, IFN‐γ, G‐CSF, GM‐CSF, MIP‐1α, MIP‐1β, IP‐10, MIG, eotaxin, RANTES, MCP‐1, MCP‐2, MCP‐3, VEGF, EGF, FGF‐basic, HGF, Gro‐α) and albumin via a fluorescent enzyme immunoassay in nasal lavage specimens of CRS patients with or without NP.Results:Topical amphotericin B had no significant effect on the level of any of the tested pro‐inflammatory cytokines, chemokines, and growth factors in CRS nasal lavage samples. Treatment with placebo, however, increased the level of MIP‐1α and MIP‐1β, which are mediators involved in wound healing.Conclusions:Topical amphotericin B has no significant effect on activation markers of nasal inflammatory cells in chronic rhinosinusitis with or without nasal polyps. Laryngoscope, 2009
Antiestrogen therapy for hereditary hemorrhagic telangiectasia: A double‐blind placebo‐controlled clinical trial
Authors: Yaniv Eitan , Preis Michal , Hadar Tuvia , Shvero Jacob , Haddad Miriam 
Published: January 2009

AbstractObjectives/Hypothesis:Hereditary hemorrhagic telangiectasia (HHT) is associated with recurrent epistaxis in 90% of cases. Good response to hormone treatment has been documented, although its use remains controversial. The aim of this study was to examine the efficacy of an antiestrogenic agent, Tamoxifen, in the treatment of HHT‐associated epistaxis.Methods:Twenty‐five patients (11 men, 14 women; mean age 51 years) with a diagnosis of epistaxis due to HHT were randomly assigned to receive treatment with oral tamoxifen 20 mg/d or placebo for 6 months. Follow‐up consisted of physical examination and once‐monthly blood tests.Results:The groups were similar in age and sex distribution. Of the 21 participants who completed the trial, alleviation of the epistaxis was noted in 9 of 10 tamoxifen‐treated patients and 3 of 11 placebo‐treated patients (including 2 with only temporary improvement). The difference between the groups at the trial end point was significant for both frequency (P= .01) and severity (P= .049) of the disease. Hemoglobin concentration rose in 4 tamoxifen‐treated patients and decreased in 5 controls.Conclusions:Tamoxifen appears to be an effective agent for the treatment of epistaxis due to HHT. Laryngoscope, 2009
Cochlear implantation is associated with minimal anesthetic risk in the elderly
Authors: Coelho Daniel H. , Yeh Joseph , Kim Jung T. , Lalwani Anil K. 
Published: January 2009

AbstractObjectives/Hypothesis:Most elderly patients with severe to profound hearing loss are not being referred for cochlear implantation (CI), the only intervention to significantly improve hearing and quality of life in this population. Possible concern over the risks of anesthetic in the elderly may be one of the foremost concerns. The authors investigated whether advanced age is a risk factor when undergoing general anesthesia for cochlear implantation.Study Design:Retrospective chart review.Methods:A retrospective chart review was conducted at a tertiary academic referral center of 70 patients older than 70 years, who underwent CI with general anesthesia between 1984 and 2007, and for whom anesthesia records were available. Patients were divided into anesthetic risk group A (American Society of Anesthesiologist classification [ASA] I/II) and B (ASA III/IV). Intraoperative and postoperative anesthesia‐related complications were identified.Results:Of the 70 patients, 44 were in group A and 26 were in group B, both with a mean age of 77. Four patients, one from group A and three from group B, required intraoperative pressors for blood pressure support. There were no anesthesia‐related complications in group A, but there were three (12% of group B and 4% overall) in group B: delayed extubation, postoperative congestive heart failure, and urinary retention. There was no long‐term morbidity or mortality.Conclusions:General anesthesia is well tolerated by elderly patients undergoing cochlear implantation. Preexisting medical condition of the patient as defined by ASA is a better predictor of intraoperative and postoperative complication than age alone. Laryngoscope, 2009
Radiotherapy in laryngeal carcinoma: Can a panel of 13 markers predict response?
Authors: Wildeman Maarten A. M. , Gibcus Johan H. , Hauptmann Michael , Begg Adrian C. , van Velthuysen Marie Louise F. , Hoebers Frank J. , Mastik Mirjam F. , Schuuring Ed , van der Wal Jacqueline E. , van den Brekel Michiel W. M. 
Published: January 2009

AbstractObjectives/Hypothesis:To find biomarkers associated with response to radiotherapy in laryngeal cancer that can be used together with clinical parameters to improve outcome prediction.Methods:In this study, 26 patients irradiated for laryngeal carcinomas with a local recurrence within two years (cases) and 33 patients without recurrence (controls) were included. All pretreatment biopsies were arrayed onto a tissue array. Immunohistochemistry was performed for 13 biomarkers that were selected from the literature as potential predictors for radioresponse in head and neck (HN) cancer: Bcl‐2, Bcl‐xL, p16, p21, p27, p53, cyclin D1, HIF‐1α, CA9, COX‐2, EGFR, ki‐67, and pRB.Results:Univariate logistic regression models showed borderline statistically significant increased relative risks, with positivity for CA9, COX‐2, and p53. Goeman's global testing revealed an overall association between outcome and the 13 markers together with clinical variables. The most important markers were CA9 and COX‐2.Conclusions:In laryngeal carcinoma, hypoxia and COX‐2 overexpression provide a stronger contribution to an increased risk of local recurrence after radiotherapy compared with the well‐known candidate markers p53, Bcl‐2, and cyclin D1. However, no robust expression profile for the prediction of radioresistance was found. Laryngoscope, 2009
Frequency of a dental source for acute maxillary sinusitis
Authors: Bomeli Steven R. , Branstetter Barton F. , Ferguson Berrylin J. 
Published: January 2009

AbstractObjective:To identify radiographic features of odontogenic acute maxillary sinusitis and to determine the frequency of a causative dental infection in patients with radiographic evidence of maxillary sinus fluid.Study Design:Retrospective review of 101 sinus computed tomography scans with unilateral or bilateral maxillary sinus fluid.Methods:Each maxillary sinus was graded for extent of fluid, degree of mucosal thickening, and presence of dental pathology. Univariate chi‐square analysis was used to identify potential radiologic and demographic features predictive of sinus fluid. Multivariate logistic regression was then used to determine which features were independently predictive.Results:124 of the 202 maxillary sinuses (61%) had sinus fluid. Univariate analysis excluded age, gender, and prior surgery as predictive features. The multivariate analysis included the radiographic features of oroantral fistula, periapical abscess, periodontal disease, projecting tooth root, and dental caries. Of these, only oroantral fistula and the combination of periodontal disease with either a projecting tooth root or periapical abscess were identified as significant sources of maxillary sinusitis. In sinuses that were <1/3 opacified by fluid, 17% had a dental source of infection. In sinuses with 1/3 to 2/3 fluid opacification, 53% had an identifiable dental source, and in sinuses that were >2/3 opacified by fluid, 79% had an identifiable dental source. Mucosal thickening demonstrated a similar relationship with dental sources, so that sinuses having both >2/3 fluid opacification and moderate mucosal thickening were 86% likely to have an identifiable dental source.Conclusions:Odontogenic infections are often the source of acute maxillary sinusitis, especially if the radiographic findings of sinusitis are severe. Laryngoscope, 2009
Substernal goiters and sternotomy
Authors: Cohen Jason P. 
Published: January 2009

AbstractObjective:To determine what factors predispose patients with retrosternal goiters to median sternotomy.Study Design:Retrospective review.Methods:Analysis of a single surgeon experience with 113 substernal goiters operated upon during a 10‐year period.Results:108 goiters were successfully removed through a cervical approach. Four patients required sternotomy, and it was concluded that one patient who did not receive sternotomy might have been better managed with sternotomy. Factors that led to sternotomy were malignancy, involvement of the posterior mediastinum, extensive substernal extension, and the presence of an ectopic nodule. The latter two were the most important factors. Revision surgery and tracheal compression did not influence the need for sternotomy.Conclusions:On the basis of preoperative imaging, it is possible to predict which patients with retrosternal goiters are likely to require median sternotomy. These factors are malignancy, extension into the posterior mediastinum, substernal extension inferior to the level of the aortic arch, and the lack of a solid attachment between the cervical and mediastinal components of the thyroid gland. Although previously reported, the latter factor has not received sufficient recognition in the management of retrosternal goiter. Laryngoscope, 2009
On the propagation of uncertainty in weather radar estimates of rainfall through hydrological models
Authors: Collier Chris. G. 
Published: January 2009

AbstractThe generation of flow forecasts using rainfall inputs to hydrological models has been developed over many years. Unfortunately, errors in input data to models may vary considerably depending upon the different sources of data such as raingauges, radar and high resolution Numerical Weather Prediction (NWP) models. This has hampered the operational use of radar for quantitative flow forecasting. The manner with which radar rainfall input and model parametric uncertainty influence the character of the flow simulation uncertainty in hydrological models has been investigated by several authors. In this paper an approach to this problem based upon a stochastic hydrological model is considered. The errors in the input data, although they may be constrained, do propagate through the model to the flow predictions. Previous work on this error propagation through a fully distributed model is described, and a similar analysis for a stochastic hydrological model implemented in a mixed rural and urban area in north‐west England carried out. Results are compared with those previously published for an American catchment. A possible approach to selecting flow forecast ensemble members is proposed. Copyright © 2009 Royal Meteorological Society
Full color light‐emitting electrospun nanofibers prepared from PFO/MEH‐PPV/PMMA ternary blends
Authors: Chen Hsieh‐Chih , Wang Cheng‐Ting , Liu Cheng‐Liang , Liu Yu‐Cheng , Chen Wen‐Chang 
Published: January 2009

AbstractIn this study, luminescence electrospun (ES) nanofibers based on ternary blends of poly(9,9‐dioctylfluoreny‐2,7‐diyl) (PFO)/poly[2‐methoxy‐5‐(2‐ethylhexyloxy)‐1,4‐phenylenevinylene] (MEH‐PPV)/poly(methyl methacrylate) (PMMA) were prepared from chloroform solutions using a single capillary spinneret. Effects of PFO/MEH‐PPV ratio on the morphology and photophysical properties were studied while the PMMA weight percentage was fixed at 90 wt %. The morphologies of the prepared ES fibers were characterized by FE‐SEM and fluorescence microscopy. The obtained fibers had diameters around a few hundred nm and pore sizes in the range of 30–35 nm. The emission colors of the PFO/MEH‐PPV/PMMA blend ES fibers changed from blue, white, yellowish‐green, greenish‐yellow, orange, to yellow, as the MEH‐PPV composition increased. In contrast, the emission colors of the corresponding spin‐coated films were blue, orange, pink‐red, red, and deep‐red. Based on the values of solubility parameters, the PFO and MEH‐PPV are miscible to each other and trapped in the PMMA matrix. Hence, energy transfer between these two polymers is possible. The smaller aggregated domains in the ES fiber compared to those of spin‐coated films possibly reduce the efficiency of energy transfer, leading to different emission colors. Also, the prepared ES fibers had higher photoluminescence efficiencies than those of the spin‐coated films. Pure white light‐emitting fibers prepared from the PFO/MEH‐PPV/PMMA blend ratio of 9.5/0.5/90 had the Commission Internationale de L'Eclairage (CIE) coordinate of (0.33, 0.31). Our results showed that different color light‐emitting ES fibers were produced through optimizing the composition of semiconducting polymer in the transparent polymer matrix. This type of ES fibers could have potential applications as new light sources or sensory materials for smart textiles. © 2009 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 47: 463–470, 2009
Organic–inorganic hybrid hydrogels involving poly(N‐isopropylacrylamide) and polyhedral oligomeric silsesquioxane: Preparation and rapid thermoresponsive properties
Authors: Zeng Ke , Fang Yuan , Zheng Sixun 
Published: January 2009

Abstract3‐Acryloxypropylhepta(3,3,3‐trifluoropropyl) polyhedral oligomeric silsesquioxane (POSS) was synthesized and used as a modifier to improve the thermal response rates of poly(N‐isopropylacrylamide) (PNIPAM) hydrogel. The radical copolymerization among N‐isopropylacrylamide (NIPAM), the POSS macromer and N,N′‐methylenebisacrylamide was performed to prepare the POSS‐containing PNIPAM cross‐linked networks. Differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA) showed that the POSS‐containing PNIPAM networks displayed the enhanced glass transition temperatures (Tg's) and improved thermal stability when compared with plain PNIPAM network. The POSS‐containing PNIPAM hydrogels exhibited temperature‐responsive behavior as the plain PNIPAM hydrogels. It is noted that with the moderate contents of POSS, the POSS‐containing PNIPAM hydrogels displayed much faster response rates in terms of swelling, deswelling, and re‐swelling experiments than plain PNIPAM hydrogel. The improved thermoresponsive properties of hydrogels have been interpreted on the basis of the formation of the specific microphase‐separated morphology in the hydrogels, that is, the POSS structural units in the hybrid hydrogels were self‐assembled into the highly hydrophobic nanodomains, which behave as the microporogens and promote the contact of PNIPAM chains and water. © 2009 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 47: 504–516, 2009
Optical properties of MOCVD HfO2 films
Authors: Ayupov Boris , Zherikova Kseniya , Gelfond Nikolai , Morozova Natalia 
Published: January 2009

AbstractHafnium(IV) 2,2,6,6‐tetramethylheptane‐3,5‐dionate Hf(thd)4 was used for depositing HfO2 coatings by MOCVD in vertical reactor in different conditions. Monochromatic null ellipsometry was applied to characterize the film thickness and refractive index using different optical model of samples. The definition of sample optical anisotropy points to the growth of HfO2 nanocrystals during film annealing. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Preparation and optical properties of Eu2+ doped CaGa2S4–CaS composite bicolor phosphor for white LED
Authors: Jabbarov R. , Musayeva N. , Scholz F. , Wunderer T. , Turkin A. N. , Shirokov S. S. , Yunovich A. E. 
Published: January 2009

AbstractIn the present paper, we report the optical properties of the bicolor composite phosphor on the base of CaS and Ga2S3 and study the possibility using this composite to obtain a white light LED. In particular, the energy transfer between the green and red emission bands of the bicolor composite phosphor activated by Eu2+ ions was studied. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Magnetic and dielectric properties of pure and doped barium hexaferrite nanoparticles at microwave frequencies
Authors: Dimri Mukesh C. , Stern R. , Kashyap Subhash C. , Bhatti K. P. , Dube D. C. 
Published: January 2009

AbstractPreparation of barium hexaferrite nanoparticles by chemical route and investigations of their dielectric and magnetic properties at microwave frequencies (8–12 GHz) are reported in the present paper. Measurements of these properties were carried out at microwave frequencies by using a cavity perturbation technique. It is observed that the values of the permittivity and permeability of nanoparticles are lower than the corresponding values for the bulk material. The effects of particle size, calcination temperature and compositional dependence on structural, microstructural and magnetic properties are also discussed. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Structural evolution and visible photoluminescence of Zn–ZnO nanophosphor
Authors: Ghosh Avijit , Choudhary R. N. P. 
Published: January 2009

AbstractThe Zn–ZnO nanostructure thin films are prepared by an inexpensive vacuum arc‐discharge method combined with vacuum annealing. The structural analysis of the grazing‐incidence X‐ray diffraction pattern using the Rietveld method showed the formation of Zn–ZnO in a single phase. The coexistence of Zn and ZnO in the thin‐film sample was also confirmed using transmission electron microscopy technique. Studies of optical properties by photoluminescence (PL) spectroscopy exhibit a strong violet emission accompanied by weak blue and green emission. The origin of defect emission of Zn–ZnO nanostructure was analyzed. Thus, the existence of metallic Zn nanocrystals embedded in ZnO islands provides a considerable change in the PL mechanism. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Magnetic field dependences of galvanomagnetic properties of polycrystalline Bi–Sb solid solutions
Authors: Rogacheva E. I. , Drozdova A. A. , Izhnin I. I. , Dresselhaus M. S. 
Published: January 2009

AbstractThe dependences of the Hall coefficientRHand magnetoresistance Δρ/ρon magnetic field (B= 0.01–1.0 T) for polycrystalline Bi–Sb solid solutions with various Sb concentrations (0–15 at% Sb) were obtained at 77 K and 300 K. On the basis of theRH(B) and Δρ/ρ(B) dependences, the values of magnetic fieldBccorresponding to the boundary of the region characterized by a constancy ofRHand a quadratic dependence of Δρ/ρ(B), i.e. satisfying the criterion of weak magnetic field behavior, were determined. It was established that a decrease in temperature leads to a shift of the critical valuesBcto smaller magnetic fields. It was shown that the dependence ofBcon composition of Bi–Sb solid solutions exhibits a non‐monotonic behavior: in the vicinity of ∼3 at% Sb and ∼8 at% Sb, where distinct minima are observed. The appearance of the minima was attributed to a sharp increase in the charge carrier mobility at the mentioned Sb concentrations due to the transition to a gapless state accompanied by the band inversion, and to the semimetal–semiconductor transition, respectively. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
CMOS‐compatible nanoscale gas‐sensor based on field effect
Authors: Velasco‐Velez J. J. , Chaiyboun A. , Wilbertz C. , Woellenstein J. , Bauersfeld M. , Doll T. 
Published: January 2009

AbstractThe integration of a solid state gas sensor of the metal oxide sensor type into CMOS technology still is a challenge because of the high temperatures during metal oxide annealing and sensor operation that do not comply with silicon device stability. In the presence of an external electric field sensor sensitivity can be controlled through a change of the Fermi energy level and consequently it is possible to reduce the operation temperature. Based in this effect, a novel field effect gas sensor was developed resembling a reversed insulated gate field effect transistor (IGFET) with the thickness of gas sensing layer in the range of the Debye length (LD). Under these conditions the controlling electrical field reaches the sensitive surface and a modulation of the Fermi energy level occurs, producing an effective control of gas sensitivity and sensor response. In this paper several aspects are treated, like technological fabrication process, complete sensor characterization by means of an electrical model and sensor response measurements. Other effects as base‐line drift effects and layer thickness implications also are studied. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Low vacuum photo electron emitting thin films
Authors: Zimmer C. , Medyanyk K. , Schoenhense G. , Krischok S. , Lorenz P. , Schubert J. , Doll T. 
Published: January 2009

AbstractImpact ionisation is a standard procedure to ionise gaseous or vaporisable substances in organic mass spectrometry. In this work, a “softer” ionisation is introduced which seems to be an alternative ion source for reducing collision between substance molecules and the hot internal walls of the box. Through collision mainly found in impact ionisation sources, fragments are built especially from thermally sensitive substances falsifying the spectra. We present here photoelectron emitting materials for the soft ionisation using semiconducting compounds, galliumn nitride (GaN), and a representative of the borides, lanthanum hexaboride (LaB6). They are evaluated by photoelectron spectroscopic studies. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Electrical insulation properties of sputter‐deposited SiO2, Si3N4 and Al2O3 films at room temperature and 400 °C
Authors: Bartzsch Hagen , Glöß Daniel , Frach Peter , Gittner Matthias , Schultheiß Eberhard , Brode Wolfgang , Hartung Johannes 
Published: January 2009

AbstractIn this paper the breakdown field strength and resistivity of sputter‐deposited Al2O3, SiO2 and Si3N4 layers are investigated in the temperature range between room temperature and 400 °C. All the investigated layers showed excellent insulation properties, even at elevated sample temperature. One example of industrial application is the deposition of electrical insulation layers onto the membranes of pressure sensors using cluster type sputter equipment