bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Salinity on the Erosion Threshold, Yield Stress, and Gelatinous State of a Cohesive Clay
Authors: San Juan Jorge E. , Wei William G. , Yang Judy Q. 
Published: March 2024

AbstractClay is the main component that contributes to sediment cohesiveness. Salinity impacts its transport, which controls the electrochemical force among the sediment grains. Here, we quantify the impacts of salinity on the erosion threshold, yield stress, and the microstructures of a fluorescently labeled smectite clay, laponite, by combining flume experiments, rheometer measurements, and macro‐ and microscopic imaging. We show that the critical shear stress for clay erosion, τb,crit, increases by one order of magnitude with increasing salinity when salinity <1.5 ppt and slightly decreases when salinity >1.5 ppt showing a weaker dependency upon salinity. We further show that the yield stress, τy, of the clay remains roughly a constant at salinity less than 1.5 ppt and decreases by over one order of magnitude at salinity larger than 1.5 ppt. This change in the dependency of τb,crit and yield stress on salinity corresponds to a change in the gelatinous state of clay, from gel‐like structures to phase‐separated structures as salinity increases. Our results provide a quantitative characterization of the dependency of clay erosion threshold and yield stress on salinity and highlight the importance of the clay gelatinous state in controlling clay transport.
Using ICON Satellite Data to Forecast Equatorial Ionospheric Instability Throughout 2022
Authors: Hysell D. L. , Kirchman A. , Harding B. J. , Heelis R. A. , England S. L. , Frey H. U. , Mende S. B. 
Published: March 2024

AbstractNumerical forecasts of plasma convective instability in the postsunset equatorial ionosphere are made based on data from the Ionospheric Connections Explorer satellite (ICON) following the method outlined in a previous study. Data are selected from pairs of successive orbits. Data from the first orbit in the pair are used to initialize and force a numerical forecast simulation, and data from the second orbit are used to validate the results 104 min later. Data from the IVM plasma density and drifts instrument and the MIGHTI red‐line thermospheric winds instrument are used to force the forecast model. Thirteen (16) data set pairs from August (October), 2022, are considered. Forecasts produced one false negative in August and another false negative in October. Possible causes of forecast discrepancies are evaluated including the failure to initialize the numerical simulations with electron density profiles measured concurrently. Volume emission 135.6‐nm OI profiles from the Far Ultraviolet (FUV) instrument on ICON are considered in the evaluation.
Ethical and Psychological Considerations for Posthumous-Assisted Reproduction for Adolescents and Young Adults With Poor Cancer Prognosis in the Context of Grief
Authors: Parchem Benjamin , Rider G. Nic , Quinn Gwendolyn P. 
Published: March 2024

Objective: Families or loved ones of adolescents and young adults (AYA) with a poor cancer prognosis who preserved fertility and did not survive treatment may choose to pursue posthumous-assisted reproduction (PAR; i.e., use of preserved reproductive material for future family-building attempts). Decisions about PAR may be occurring in the context of grief and bereavement, which is associated with ethical and psychological considerations because grief can complicate a person’s capacity for informed decision-making. Method: Through the use of a five-step ethical decision-making model, the American Psychological Association’s Ethical Principles of Psychologists and Code of Conduct, and a blended case example, the ethical and psychological considerations for families of AYA with poor prognosis who pursue PAR are discussed with an ethical analysis. Results: Ethical and psychological considerations included assessing the potential for harm to involved parties, navigating PAR decision-making with responsibility and honesty, examining the accessibility of PAR, and considering informed consent/assent and autonomy. Conclusions: Clinical recommendations for supporting families and loved ones exploring PAR in the context of grief were discussed, with considerations for improving clinicians’ comfort and competence with PAR, incorporating grief into informed consent conversations, standardizing conversations about PAR, and promoting an interdisciplinary approach to PAR-related decisions. Implications for Impact Statement Families or partners who have lost their adolescent or young adult loved one to cancer may wish to pursue posthumous-assisted reproduction (PAR; i.e., using the deceased’s reproductive material for future family-building attempts). Families and partners may be experiencing grief when making decisions about PAR, which can raise ethical and psychological concerns. Pediatric psychologists are uniquely positioned to support surviving loved ones pursuing PAR in the context of grief to educate on the ways that grief can complicate decision-making processes and offer mental health support, while also respecting the autonomy of decision-makers.
Association of semaglutide with reduced incidence and relapse of cannabis use disorder in real-world populations: a retrospective cohort study
Authors: Wang William , Volkow Nora D. , Berger Nathan A. , Davis Pamela B. , Kaelber David C. , Xu Rong 
Published: March 2024

AbstractCannabis is the most frequently used illicit drug in the United States with more than 45 million users of whom one-third suffer from a cannabis use disorder (CUD). Despite its high prevalence, there are currently no FDA-approved medications for CUD. Patients treated with semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA) approved for treating type 2 diabetes (T2D) and for weight management have reported reduced desire to drink and smoke. Preclinical studies have shown that semaglutide decreased nicotine and alcohol consumption. Preclinical and preliminary clinical evidence of semaglutide’s potential beneficial effects on various substance use disorders led us to evaluate if it pertained to CUD. In this retrospective cohort study of electronic health records (EHRs) from the TriNetX Analytics Network, a global federated health research network of approximately 105.3 million patients from 61 large healthcare organizations in the US, we aimed to assess the associations of semaglutide with both incident and recurrent CUD diagnosis compared to non-GLP-1RA anti-obesity or anti-diabetes medications. Hazard ratio (HR) and 95% confidence intervals (CI) of incident and recurrent CUD were calculated for 12-month follow-up by comparing propensity-score matched patient cohorts. The study population included 85,223 patients with obesity who were prescribed semaglutide or non-GLP-1RA anti-obesity medications, with the findings replicated in 596,045 patients with T2D. In patients with obesity (mean age 51.3 years, 65.6% women), semaglutide compared with non-GLP-1RA anti-obesity medications was associated with lower risk for incident CUD in patients with no prior history CUD (HR: 0.56, 95% CI: 0.42–0.75), and recurrent CUD diagnosis in patients with a prior history CUD (HR: 0.62, 95% CI: 0.46–0.84). Consistent reductions were seen for patients stratified by gender, age group, race and in patients with and without T2D. Similar findings were replicated in the study population with T2D when comparing semaglutide with non-GLP-1RA anti-diabetes medications for incident CUD (HR: 0.40, 95% CI: 0.29–0.56) and recurrent CUD (HR: 0.66, 95% CI: 0.42–1.03). While these findings provide preliminary evidence of the potential benefit of semaglutide in CUD in real-world populations, further preclinical studies are warranted to understand the underlying mechanism and randomized clinical trials are needed to support its use clinically for CUD.
TWIST1 is a critical downstream target of the HGF/MET pathway and is required for MET driven acquired resistance in oncogene driven lung cancer
Authors: Kumar Vinod , Yochum Zachary A. , Devadassan Princey , Huang Eric H.-B. , Miller Ethan , Baruwal Roja , Rumde Purva H. , GaitherDavis Autumn L. , Stabile Laura P. , Burns Timothy F. 
Published: March 2024

AbstractMET amplification/mutations are important targetable oncogenic drivers in NSCLC, however, acquired resistance is inevitable and the majority of patients with targetable MET alterations fail to respond to MET tyrosine kinase inhibitors (TKIs). Furthermore, MET amplification is among the most common mediators of TKI resistance. As such, novel therapies to target MET pathway and overcome MET TKI resistance are clearly needed. Here we show that the epithelial-mesenchymal transition (EMT) transcription factor, TWIST1 is a key downstream mediator of HGF/MET induced resistance through suppression of p27 and targeting TWIST1 can overcome resistance. We found that TWIST1 is overexpressed at the time of TKI resistance in multiple MET-dependent TKI acquired resistance PDX models. We have shown for the first time that MET directly stabilized the TWIST protein leading to TKI resistance and that TWIST1 was required for MET-driven lung tumorigenesis as well as could induce MET TKI resistance when overexpressed. TWIST1 mediated MET TKI resistance through suppression of p27 expression and genetic or pharmacologic inhibition of TWIST1 overcame TKI resistance in vitro and in vivo. Our findings suggest that targeting TWIST1 may be an effective therapeutic strategy to overcome resistance in MET-driven NSCLC as well as in other oncogene driven subtypes in which MET amplification is the resistance mechanism.
Moringa oleifera leaf extract promotes the healing of critical sized bone defects in the mandibles of rabbits
Authors: Elsadek Nouran A. , Aboukhadr Maha A. , Kamel Fatma R. , Mostafa Hossam M. , El-Kimary Gillan I. 
Published: March 2024

Abstract
Objective
The search for an osteopromotive material that enhances the efficacy of alloplasts in reconstructive surgeries has been going on for years. This study aimed to histologically and histomorphometrically evaluate the efficiency of Moringa oleifera leaf extract as an osteopromotive biomaterial.

Design
The study is a prospective randomized controlled animal study. 24 adult male New Zealand rabbits were equally allocated into test and control groups. Critical-sized bone defects were created in the edentulous areas of the mandibles of rabbits. The defects of the control group were filled with Beta-tricalcium Phosphate, while the defects of the test group were filled with Beta-tricalcium Phosphate combined with Moringa oleifera leaf extract. The results were evaluated histologically and histomorphometrically.

Results
Histological and histomorphometric analysis showed a significant increase in the surface area of bone and the number of osteoblasts in test groups compared to those in the control groups.

Conclusion
Moringa oleifera leaf extract has a positive effect on bone regeneration in critical-sized bone defects.
Systematic reanalysis of genomic data by diagnostic laboratories: a scoping review of ethical, economic, legal and (psycho)social implications
Authors: van der Geest Marije A. , Maeckelberghe Els L. M. , van Gijn Marielle E. , Lucassen Anneke M. , Swertz Morris A. , van Langen Irene M. , Plantinga Mirjam 
Published: March 2024

AbstractWith the introduction of Next Generation Sequencing (NGS) techniques increasing numbers of disease-associated variants are being identified. This ongoing progress might lead to diagnoses in formerly undiagnosed patients and novel insights in already solved cases. Therefore, many studies suggest introducing systematic reanalysis of NGS data in routine diagnostics. Introduction will, however, also have ethical, economic, legal and (psycho)social (ELSI) implications that Genetic Health Professionals (GHPs) from laboratories should consider before possible implementation of systematic reanalysis. To get a first impression we performed a scoping literature review. Our findings show that for the vast majority of included articles ELSI aspects were not mentioned as such. However, often these issues were raised implicitly. In total, we identified nine ELSI aspects, such as (perceived) professional responsibilities, implications for consent and cost-effectiveness. The identified ELSI aspects brought forward necessary trade-offs for GHPs to consciously take into account when considering responsible implementation of systematic reanalysis of NGS data in routine diagnostics, balancing the various strains on their laboratories and personnel while creating optimal results for new and former patients. Some important aspects are not well explored yet. For example, our study shows GHPs see the values of systematic reanalysis but also experience barriers, often mentioned as being practical or financial only, but in fact also being ethical or psychosocial. Engagement of these GHPs in further research on ELSI aspects is important for sustainable implementation.
Risk of heart failure in ambulatory resistant hypertension: a meta-analysis of observational studies
Authors: Coccina Francesca , Salles Gil F. , Banegas José R. , Hermida Ramón C. , Bastos José M. , Cardoso Claudia R. L. , Salles Guilherme C. , Sánchez-Martínez Mercedes , Mojón Artemio , Fernández José R. , Costa Carlos , Carvalho Simão , Faia Joao , Pierdomenico Sante D. 
Published: March 2024

AbstractThe impact of ambulatory resistant hypertension (ARH) on the occurrence of heart failure (HF) is not yet completely known. We performed for the first time a meta-analysis, by using published data or available data from published databases, on the risk of HF in ARH. Patients with ARH (24-h BP ≥ 130/80 mmHg during treatment with ≥3 drugs) were compared with those with controlled hypertension (CH, clinic BP < 140/90 mmHg and 24-h BP < 130/80 mmHg regardless of the number of drugs used), white coat uncontrolled resistant hypertension (WCURH, clinic BP ≥ 140/90 mmHg and 24-h BP < 130/80 mmHg in treated patients) and ambulatory nonresistant hypertension (ANRH, 24-h BP ≥ 130/80 mmHg during therapy with ≤2 drugs). We identified six studies/databases including 21,365 patients who experienced 692 HF events. When ARH was compared with CH, WCURH, or ANRH, the overall adjusted hazard ratio for HF was 2.32 (95% confidence interval (CI) 1.45–3.72), 1.72 (95% CI 1.36–2.17), and 2.11 (95% CI 1.40–3.17), respectively, (all P < 0.001). For some comparisons a moderate heterogeneity was found. Though we did not find variables that could explain the heterogeneity, sensitivity analyses demonstrated that none of the studies had a significant influential effect on the overall estimate. When we evaluated the potential presence of publication bias and small-study effect and adjusted for missing studies identified by Duval and Tweedie’s method the estimates were slightly lower but remained significant. This meta-analysis shows that treated hypertensive patients with ARH are at approximately twice the risk of developing HF than other ambulatory BP phenotypes.
Dzyaloshinskii-Moriya interactions, Néel skyrmions and V4 magnetic clusters in multiferroic lacunar spinel GaV4S8
Authors: Borisov Vladislav , Salehi Nastaran , Pereiro Manuel , Delin Anna , Eriksson Olle 
Published: March 2024

AbstractUsing ab initio density functional theory with static mean-field correlations, we calculate the Heisenberg and Dzyaloshinskii-Moriya interactions (DMI) for an atomistic spin Hamiltonian for the lacunar spinel, GaV4S8. The parameters describing these interactions are used in atomistic spin dynamics and micromagnetic simulations. The magnetic properties of the lacunar spinel GaV4S8, a material well-known from experiment to host magnetic skyrmions of Néel character, are simulated with these ab initio calculated parameters. The Dzyaloshinskii-Moriya contribution to the micromagnetic energy is a sum of two Lifshitz invariants, supporting the formation of Néel skyrmions and its symmetry agrees with what is usually expected for C3ν-symmetric systems. There are several conclusions one may draw from this work. One concerns the quantum nature of the magnetism, where we show that the precise magnetic state of the V4 cluster is crucial for understanding quantitatively the magnetic phase diagram. In particular, we demonstrate that a distributed-moment state of each V4 cluster explains well a variety of properties of GaV4S8, such as the band gap, observed Curie temperature and especially the stability of Néel skyrmions in the experimentally relevant temperature and magnetic-field range. In addition, we find that electronic correlations change visibly the calculated value of the DMI.
Flat-band hybridization between f and d states near the Fermi energy of SmCoIn5
Authors: Tam David W. , Colonna Nicola , Alarab Fatima , Strocov Vladimir N. , Gawryluk Dariusz Jakub , Pomjakushina Ekaterina , Kenzelmann Michel 
Published: March 2024

AbstractWe present high-quality angle-resolved photoemission (ARPES) and density functional theory calculations (DFT+U) of SmCoIn5. We find broad agreement with previously published studies of LaCoIn5 and CeCoIn51,2, confirming that the Sm 4f electrons are mostly localized. Nevertheless, our model is consistent with an additional delocalized Sm component, stemming from hybridization between the 4f electrons and the metallic bands at “hot spot” positions in the Brillouin zone. The dominant hot spot, called γZ, is similar to a source of delocalized f states found in previous experimental and theoretical studies of CeCoIn51,3. In this work, we identify and focus on the role of the Co d states in exploring the relationship between heavy quasiparticles and the magnetic interactions in SmCoIn5, which lead to a magnetically ordered ground state from within an intermediate valence scenario4–6. Specifically, we find a globally flat band consisting of Co d states near E = − 0.7 eV, indicating the possibility of enhanced electronic and magnetic interactions in the “115” family of materials through localization in the Co layer, and we discuss a possible origin in geometric frustration. We also show that the delocalized Sm 4f states can hybridize directly with the Co 3dxz/3dyz orbitals, which occurs in our model at the Brillouin zone boundary point R in a band that is locally flat and touches the Fermi level from above. Our work identifies microscopic ingredients for additional magnetic interactions in the “115” materials beyond the RKKY mechanism, and strongly suggests that the Co d bands are an important ingredient in the formation of both magnetic and superconducting ground states.
Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination
Authors: Fumagalli Valeria , Ravà Micol , Marotta Davide , Di Lucia Pietro , Bono Elisa B. , Giustini Leonardo , De Leo Federica , Casalgrandi Maura , Monteleone Emanuele , Mouro Violette , Malpighi Chiara , Perucchini Chiara , Grillo Marta , De Palma Sara , Donnici Lorena , Marchese Silvia , Conti Matteo , Muramatsu Hiromi , Perlman Stanley , Pardi Norbert , Kuka Mirela , De Francesco Raffaele , Bianchi Marco E. , Guidotti Luca G. , Iannacone Matteo 
Published: March 2024

AbstractVaccines have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality, yet emerging variants challenge their effectiveness. The prevailing approach to updating vaccines targets the antibody response, operating under the presumption that it is the primary defense mechanism following vaccination or infection. This perspective, however, can overlook the role of T cells, particularly when antibody levels are low or absent. Here we show, through studies in mouse models lacking antibodies but maintaining functional B cells and lymphoid organs, that immunity conferred by prior infection or mRNA vaccination can protect against SARS-CoV-2 challenge independently of antibodies. Our findings, using three distinct models inclusive of a novel human/mouse ACE2 hybrid, highlight that CD8+ T cells are essential for combating severe infections, whereas CD4+ T cells contribute to managing milder cases, with interferon-γ having an important function in this antibody-independent defense. These findings highlight the importance of T cell responses in vaccine development, urging a broader perspective on protective immunity beyond just antibodies.
Self-help mobile messaging intervention for depression among older adults in resource-limited settings: a randomized controlled trial
Authors: Scazufca Marcia , Nakamura Carina Akemi , Seward Nadine , Didone Thiago Vinicius Nadaleto , Moretti Felipe Azevedo , Oliveira da Costa Marcelo , Queiroz de Souza Caio Hudson , Macias de Oliveira Gabriel , Souza dos Santos Monica , Pereira Luara Aragoni , Mendes de Sá Martins Mariana , van de Ven Pepijn , Hollingworth William , Peters Tim J. , Araya Ricardo 
Published: March 2024

AbstractScalable solutions to treat depression in older adults in low-resourced settings are urgently needed. The PRODIGITAL-D pragmatic, single-blind, two-arm, individually randomized controlled trial assessed the effectiveness of a mobile messaging psychosocial intervention in improving depressive symptomatology among older adults in socioeconomically deprived areas of Guarulhos, Brazil. Older adults (aged 60+ years) registered with 24 primary care clinics and identified with depressive symptomatology (9-item Patient Health Questionnaire (PHQ-9) scores ≥ 10) received the 6-week Viva Vida intervention based on psychoeducation and behavioral activation (n = 298) or a single message (n = 305). No health professional support was offered. The primary outcome was improvement from depressive symptomatology (PHQ-9 < 10) at 3 months. Of the 603 participants enrolled (mean age = 65.1 years; 451 (74.8%) women), 527 (87.4%) completed the follow-up assessment. In the intervention arm, 109 of 257 (42.4%) participants had an improved depressive symptomatology, compared with 87 of 270 (32.2%) participants in the control arm (adjusted odds ratio = 1.57; 95% confidence interval = 1.07–2.29; P = 0.019). No severe adverse events related to trial participation were observed. These results demonstrate the usefulness of a digital messaging psychosocial intervention in the short-term improvement from depressive symptomatology that can potentially be integrated into primary care programs for treating older adults with depression. Brazilian Registry of Clinical Trials registration: ReBEC (RBR-4c94dtn).
An extensive database on the traits and occurrences of amphibian species in Turkey
Authors: Arslan Dilara , Akdağ Burak , Yaşar Çağdaş , Olivier Anthony , Benedetti Yanina , Morelli Federico , Çiçek Kerim 
Published: March 2024

AbstractAmphibians are the most endangered taxa among vertebrates, and they face many threats during their complex life cycles. The species’ life history traits and occurrence database help understand species responses against ecological factors. Consequently, the species-level-trait database has gained more prominence in recent years as a useful tool for understanding the dimensions of communities, assembly processes of communities, and conserving biodiversity at the ecosystem level against environmental changes. However, in Turkey, there are deficiencies in the knowledge of the ecological traits of amphibians compared to other vertebrate taxa, as most studies have focused on their distribution or taxonomic status. Consequently, there is a need to create such a database for future research on all known extant amphibians in Turkey. We compiled a species-level data set of species traits and occurrences for all amphibians in Turkey using 436 literature sources. We completed 36 trait categories with 5611 occurrence data for 37 amphibian species in Turkey. This study provides an open, useful, and comprehensive database for macroecological and conservation studies on amphibians in Turkey.