bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seven years experience with hyperthermic perfusions in extracorporeal circulation for melanoma of the extremities
Authors: Santinami Mario , Belli Filiberto , Cascinelli Natale , Rovini Dario , Vaglini Maurizio 
Published: February 2007

AbstractOne hundred forty patients affected by high risk or locally advanced melanoma of the extremities were submitted to hyperthermic perfusion in extracorporeal circulation at the National Cancer Institute of Milan, Italy. Using adequate temperature and drug dosage, we increased survival of stage IIIA patients from 8‐15% to 51% and stage IIIAB patients from 7‐8% to 35%, and good local control was achieved in stage IV patients. A comparison was made with 297 patients with similar disease treated in a previous period in this institute with conventional therapies such as surgery with or without chemotherapy. In stage IIIA patients we obtained 51% overall survival at 5 years in perfused cases, whereas survival in the series with conventional treatment reached 16%. Similarly, in stage IIIAB patients we observed 34% (perfused) versus 16% (conventional treatment) survival. There are still no data available for high‐risk stage I, in which perfusion is employed as an adjuvant treatment.
Isolated breast metastases from gastrointestinal carcinomas: Report of two cases
Authors: Alexander H. Richard , Turnbull Alan D. , Rosen Paul Peter 
Published: February 2007

AbstractTwo patients with metastatic gastrointestinal adenocarcinoma in the breast are reported. Metastases in the breast are usually painless upper outer quadrant masses. On mammography they are typically well‐circumscribed lesions without microcalcifications. A breast mass in a patient with a history of cancer, even if clinically or mammographically benign, should raise suspicion of a metastasis. Pathological features include a histologic pattern similar to the primary neoplasm and an absence of in situ carcinoma which characterizes primary breast cancer. Surgical excision for local control and systematic therapy is the most appropriate treatment.
Relation of proliferative activity to survival in patients with gastric carcinoma
Authors: Tonemura Yutaka , Kamata Toru , Ooyama Shigekazu , Sugiyama Kazuo , Kimura Hironobu , Kosaka Takeo , Yamaguchi Akio , Miyazaki Itsuo 
Published: February 2007

AbstractThe prognostic significance of proliferative activity in 167 gastric carcinomas was studied by means of an in vitro labeling method with bromodeoxyuridine (BrdU), using specimens obtained by endoscopic biopsy, and the results were correlated with conventional prognostic factors. The BrdU labeling indices (BrdU LI) varied from 2.1 to 45%. When the in vitro BrdU LI were plotted against in vivo BrdU LI, a significant correlation was found between in vitro and in vivo BrdU LI (P< .01). These results show that the in vitro BrdU LI of specimens obtained by endoscopic biopsy indicate accurate proliferative activities of gastric cancers. The BrdU LI were closely correlated with nodal status, vessel invasion, and tumor size. With regard to the correlation of BrdU LI and prognosis, patients whose tumors had a high BrdU LI (BrdU greater than 10%) died significantly earlier than did those with low BrdU LI (BrdU LI less than 10%). When the BrdU LI and all the pathologic findings were entered simultaneously into the regression model, nodal status, tumor size, serosal involvement, and BrdU LI emerged as independent prognostic parameters. The present studies demonstrated the usefulness of the in vitro BrdU‐labeling method to estimate the malignancy of gastric cancer preopera‐tively, and this method may be useful in designing the operative procedure and multimodal therapy for individual patients.
Safety of EEA staplers for anastomosis between upper esophagus and the gastric tube
Authors: Sugimachi Keizo , Ohno Shinji , Maekawa Soichiro , Mori Masaki , Kuwano Hiroyuki , Ueo Hiroaki 
Published: February 2007

AbstractThe EEA stapling devices used for intrathoracic anastomosis between the upper esophagus and the gastric tube in patients with carcinoma of the thoracic esophagus were evaluated, and the results were compared with those of an antesternally reconstructed esophagus. These approaches were both used by the same surgical team. An intrathoracic anastomosis using the EEA stapler was made in 53 patients with carcinoma of the thoracic esophagus. Minor anastomotic leakage occurred in five patients (9.4%). Good results were obtained with total parenteral nutrition for 2 weeks. Intrathoracic anastomotic complications were never fatal. Among another 106 patients with antesternally reconstructed esophagus, with the EEA stapler there were 28 patients with anastomotic leakage (26.4%) and two operative mortalities (1.9%). Intrathoracic anastomosis with the EEA stapler is recommended because it is secure and the operative procedure is simple and time‐saving. For successful use of the instrument. proper technical procedures must be followed.
Site, size, and tumour involvement of resected extrapulmonary lymph nodes in lung cancer
Authors: Kayser K. , Bach S. , Bülzebruck H. , Vogt‐Moykopf I. , Probst C. 
Published: February 2007

AbstractA prospective study was performed analyzing resected extrapulmonary lymph nodes of 544 operated lung carcinoma patients. Volume of lymph nodes was determined by weight. Lymph nodes were cut in serial sections 300 μm thick, and the volume of tumour metastasis in each resected lymph node was computed measuring the tumourous area in the lymph node sections. The following results were obtained: Percentage of resected lymph nodes varied with lymph node site and site of the primary lung cancer. Hilar lymph nodes were resected in 50% of the patients, lymph nodes of the main and stem bronchi in 57% and 63%, respectively. Tumour metastases were found in 10%‐15% of the resected lymph nodes. The size of the lymph nodes varied to a large amount and was found to be independent of the lymph node site if no metastases could be detected. Lymph nodes measuring <0.1 ccm were tumour infiltrated in 9% (77/706 lymph nodes), large lymph nodes (>10 ccm) in 62% of the cases (20/32). Tumourous involved lymph nodes of the main bronchus were found more frequently in cases of central localized lung cancer compared to carcinoma arising from the peripheral lung, where the opposite was seen in subaortal located lymph nodes. The percentage of lymph node involvement and size of tumour infiltrated lymph nodes was found to be independent of tumour cell type. Size of resected lymph nodes is not a reliable parameter for estimating existence of tumour infiltrations.
Gastroesophageal anastomotic leakage following resection of carcinoma of the esophagus and gastric cardia: Analysis of ten cases
Authors: Tang Guo‐Xue , Wang Zhe‐Sheng , Liu De‐Gui , Liu Shun‐Shou 
Published: February 2007

AbstractPostoperative anastomotic leakage is one of the most dangerous and, unfortunately, most frequent complications. Many methods have been tried to prevent such leakage. The incidence of leakage has decreased to 3.84% in our hospital in recent years. Ten cases of gastroesophageal anastomotic leakage following resection of carcinoma of the esophagus and gastric cardia are analyzed and a new tool, the three‐leaf clamp, which reduced the anastomotic leakage, is introduced.
Inhibition of the growth of human melanoma xenografts in nude mice by human tumor‐specific cytotoxic T‐cells
Authors: Crowley Nancy J. , Slingluff Craig L. , Vervaert Carol E. , Darrow Timothy L. , Seigler Hilliard F. 
Published: February 2007

AbstractMelanoma‐specific T‐cells (CTLs) are specifically cytotoxic for autologous tumor, when assayed in vitro. To examine their effectiveness in vivo, we tested the ability of these human T‐cells to inhibit growth of human melanoma xenografts by using a Winn assay. Nude mice receiving specific CTLs (n = 10) demonstrated a dramatic inhibition of tumor growth. All treated mice were tumor‐free at day 50 and nine remained tumor‐free at day 65, vs. control mice (n= 10) with average tumor volumes of 321 mm3 and 808 mm3, respectively. To control for the possibility that a non‐specific response to the human T‐cells could inhibit tumor growth, an additional group received allospecific CTLs. There was no inhibition of tumor growth in this group (n =8), with the average tumor volume of 2,768 mm3 at day 40 vs. 1,882 mm3 in the control group (n = 10). We conclude that these tumor‐specific CTLs can inhibit tumor growth in vivo and may prove useful in the adoptive immunotherapy of melanoma.
Distribution of fibronectin in adenocarcinoma of the lung: Classification and prognostic significance
Authors: Nishino Toyohiko , Ishida Teruyoshi , Oka Takeshi , Yasumoto Kosei , Sugimachi Keizo 
Published: February 2007

AbstractFibronectin (FN) was investigated in 75 stroma from lung adenocarcinoma patients. Distribution of FN was classified into three patterns based on immunohistochemical evidence: dense, moderate, and sparse distribution. The incidence of the sparse pattern in both stage I and stage III disease was significantly greater in the infiltrating than in the noninfiltrating areas. The patients were divided into two groups, long‐term survivors and short‐term survivors. In the group with stage I disease, the incidence of the sparse pattern was significantly greater in the infiltrating than in the non‐infiltrating areas. In both areas, the incidence of sparse pattern was greater in the short‐term than in the long‐term survivors. These data suggest that the disappearance of FN reflects the aggressiveness of the tumor and presumably plays an important role in the prognosis of adenocarcinoma of the lung.
Malignant eccrine spiradenoma of the hand
Authors: Zamboni Anthony C. , Zamboni William A. , Ross Donald S. 
Published: February 2007

AbstractA malignant eccrine spiradenoma (MES) of the hand is described in a patient who developed bilateral pulmonary metastasis more than 10 years later. A review of the literature including observations on clinical behavior and recommendations for treatment of this rare adnexal tumor is presented.
Role of adrenal imaging in surgical management
Authors: Lamki Lamk M. , Haynie Thomas P. 
Published: February 2007

AbstractAdrenal imaging using radiopharmaceuticals is a functional test that can contribute significantly to surgical management and follow‐up of patients with either benign or malignant conditions of the adrenal cortex and medulla. Imaging of the cortex is achieved by iodine‐131‐labeled iodomethyl nor‐cholesterol (NP‐59), while adrenal medulla imaging can be successfully accomplished by 131I‐metaiodobenzylguanidine (MIBG), which localizes in the adrenergic nerve terminal with norepinephrine. Both tests carry high sensitivity and specificity for functional tumors and hyperplasia, and often better than CT scanning. This article reviews the current status and clinical utility of nuclear imaging of the adrenal cortex in congenital hyperplasia, low renin hypertension and aldosteronism, and Cushing's syndrome. Adrenal medulla imaging is reviewed in light of our experience at the University of Texas M.D. Anderson Cancer Center in pheochromocytoma, neuroblastoma, and other neuroectodermal tumors. Investigation of 131I‐MIBG therapy of metastatic tumors of neuroectodermal origin potentially offers a means of at least controlling symptoms of hormonal secretion in these patients.
Long‐term survival in patients treated for testicular seminoma
Authors: Hannun Yusef , Vugrin Davor 
Published: February 2007

AbstractForty‐eight patients with newly‐diagnosed testicular seminomas were followed for a mean of 7 years after treatment. At the time of diagnosis, seminoma was confined to testis in 74% (36) and was metastatic to retroperitoneal lymph nodes in 15% (7) and to distant nodal sites or parenchymal organs in 10% (5). Ninety‐six percent remained free of disease, 94% in first complete remission (CR) and 2% after treatment of first recurrence. Long‐term disease‐free survival in CR per stage was 97% (35/36) for Stage I, 100% for Stage II, and 80% (4/5) for Stage III. However, three patients, who received prior chest radiation therapy (RT), died from acute myocardial infarction 2, 9, and 10 years after treatment and while free of disease.
Impact of the time interval between surgery and postoperative radiation therapy on locoregional control in advanced head and neck cancer
Authors: Schiff Peter B. , Harrison Louis B. , Strong Elliot W. , Fass Daniel E. , Shah Jatin P. , Spiro Ronald , Sessions Roy , Gerold Frank , Vikram Bhadrasain , Fuks Zvi Y. 
Published: February 2007

AbstractBetween January 1975 and December 1980, 111 patients with AJCC stages III and IV squamous cell carcinoma of the head and neck were treated with surgery followed by planned postoperative radiation therapy. A previous analysis of a subgroup of these patients showed that, when radiation was delayed more than 6 weeks from surgery, a higher incidence of regional failure occurred compared with the incidence observed when therapy began within a 6 week period. We have looked back at this group of patients plus others in an attempt to determine whether other factors played a role in the results obtained. In the current study, 50 patients had a delay of 6 weeks or more and, of these, 11 (22%) suffered a locoregional recurrence. However, 8 of these 11 patients received suboptimal radiation doses (less than 56 Gy) for permanent control of the disease. In fact, of 17 patients who received at least 60 Gy and had more than a 6 week delay, only 2 (12%) had locoregional failure. This was similar to the incidence of failure in the patients who received at least 60 Gy and who started radiation within the first 6 weeks from surgery (3/20 [15%]). The effect of delay was apparent only in those who received less than 60 Gy (27% vs. 7%, P < 0.05). Therefore, we cannot validate the previous conclusion that a greater than 6 week delay in the delivery of postoperative radiation therapy in advanced head and neck cancers produces poorer results. The current analysis suggests that a prolonged delay in postoperative radiation therapy in itself does not have a negative impact on locoregional control as long as appropriate tumorcidal doses of more than 60 Gy are employed.
Prognostic significance of laminin in adenocarcinoma of the lung
Authors: Nishino Toyohiko , Ishida Teruyoshi , Oka Takeshi , Yasumoto Kosei , Sugimachi Keizo 
Published: February 2007

AbstractThe distribution of laminin in tumor‐associated basement membrane was immunohistochemically investigated in 115 cases of adenocarcinoma of the lung. The distribution of laminin was classified into continuous and discontinuous staining patterns. The incidence of the discontinuous pattern was less in early‐stage disease than that in advanced stages (P < 0.01). In patients with stage I, the incidence of discontinuous patterns was greater in short‐term survivors than in long‐term survivors (P < 0.05). By contrast, in patients with stage III, the discontinuous pattern of laminin was frequently seen in both long‐term survivors and short‐term survivors, with no difference between the two groups. These data suggest that the discontinuous pattern of laminin in tumor‐associated basement membrane reflects the spread and dissemination of tumor, hence a close relationship to the prognosis.
Bloody nipple discharge during pregnancy: A rationale for conservative treatment
Authors: Lafreniere Rene 
Published: February 2007

AbstractFive cases of bloody nipple discharge during pregnancy without associated breast masses were seen over the past 3 years by the author. Because of the reported association of breast cancer with bloody nipple discharge, close follow‐up of these women at monthly intervals during pregnancy and trimonthly during the postpartum period was carried out. In all instances, the discharge appeared late during the second trimester or during the third trimester of pregnancy. It was unilateral and spontaneous and arose from multiple ducts, and it was associated with an increase in breast size and always with the larger breast of the two. The discharge cytologic study done on all cases was negative for neoplastic cells and the discharges resolved spontaneously within 2 months of onset. Postpartum follow‐up ranging from 6 months to 3 years has revealed no evidence of neoplastic changes thus far. Mammograms ordered before these patients were referred were not helpful due to the increase in density of the breast tissue secondary to the pregnancy. Because a few cases of breast cancer during pregnancy have presented solely with a bloody nipple discharge, I recommend extremely close follow‐up of these women and no surgical intervention unless a mass is discovered or the nipple discharge cytology is either suspicious or positive at the initial visit or during follow‐up.
Combined hormonal therapy with high‐dose diethylstilbestrol diphosphate (DES‐DP) intravenous infusion plus vindesine (VND) for the treatment of advanced prostatic carcinoma: A controlled study
Authors: Cervellino Juan C. , Araujo Carlos E. , Pirisi Claudia , Podskubka Oscar , Morera Eduardo 
Published: February 2007

AbstractFifty‐one patients with stage D prostate cancer, who had failed primary hormone treatment, were treated with diethylstilbestrol diphosphate (DES‐DP) 1.5 g 24 hr intravenous infusion from day 1 to day 7 (group A). In group B, patients were treated with DES‐DP as in A, plus vindesine (VND) 3 mg/m2 intravenously on days 8, 15, and 22. Cycles were repeated every 28 days for six consecutive cycles. All 51 patients were evaluable for response, toxicity, time to progression, and survival. Pre‐treatment clinical and laboratory characteristics were comparable. The National Prostatic Cancer Project Criteria were used for evaluation. A minimum of two cycles were required for evaluation of response. No complete response was seen. In group A, 9 “partial response” and 7 “no change” (80%), and in group B. 11 “partial response” and 12 “no change” (74%) were registered. Median survival time was 40 weeks. Toxicity ranged from mild to moderate. DES‐DP + VND seemed to improve duration of objective response compared to DES‐DP alone, but the difference was not significant.
Evaluation of voice by patients and close relatives following different laryngeal cancer treatments
Authors: Schuller David E. , Trudeau Michael , Bistline Jane , Laface Karen 
Published: February 2007

AbstractThe purpose of this study was to assess perception of life style change among laryngeal cancer patients. Seventy‐five patients (total laryngec‐tomy 35, supraglottic laryngectomy 15, hemilaryngectomy 12, radiotherapy eight, laser cordectomy five) and close relatives responded to a questionnaire and interview eliciting perception of: 1) posttreatment voice quality; 2) side effects of treatment vocationally and socially; and 3) degree of vocal or communicative change associated with vocational or social change. Whereas 43% of the patients reported vocational change and 37% reported social change, 88% expressed satisfaction with their posttreatment voices. This may have been due to the perceptions of the relatives, who generally had a more positive view of the patients' voices. Although laryngeal cancer had an impact on patient life style, patients seldom related this to vocal dysfunction.
Laryngotracheal invasion by well‐differentiated thyroid cancer: Diagnosis and management
Authors: Britto Errol , Mbbs Sushila Shah , Parikh Deepak M. , Rao Raja S. 
Published: February 2007

AbstractTen cases of laryngotracheal invasion by well‐differentiated thyroid cancer are described. All the patients were over 40 years of age, with a male preponderance of 4:1. A mass in the neck, stridor, and hemoptysis was the common symptom. Bronchoscopy done in six of ten patients revealed an intraluminal tumour in all. Radiographs of the neck showed invasion of the trachea in six patients. Surgery consisted of tracheostomy alone (three of ten), total thyroidectomy with laryngectomy (one of ten), circumferential resection of trachea (one of ten), and total thyroidectomy with tracheotomy and “shaving” of the intraluminal disease in five of ten patients. Adjuvant external radiation, radioiodine, or laser therapy was given when indicated. Of the ten patients, three died and seven survived. Five of seven were alive without disease for 2.5 years or more, and one had skull metastasis 2 years later but no local disease.
Correlation between mammography and the pathology of nonpalpable breast lesions
Authors: Albert Michael P. , Sachsse Eckart , Coe Nicholas P. W. , Pace David W. , Reed William P. 
Published: February 2007

AbstractOne hundred consecutive needle localization biopsies were performed for nonpalpable breast lesions discovered on low‐dose mammography of asymptomatic women between June, 1984, and August, 1986. Malignant disease was found on 21 biopsies. Four were carcinoma in situ, and 17 were infiltrating carcinomas. Only three of the infiltrating carcinomas had metastasized to regional nodes, as confirmed by subsequent axillary dissection. Two of these metastatic tumors involved two nodes and the third only one. The findings on the remaining 79 biopsies were benign. Forty‐eight mammograms were read as “benign”; all (100%) were benign pathologically. Thirty‐one mammograms were considered “malignant”; 19 (61%) were malignant pathologically. Only two of the 21 mammograms given “suspicious” interpretations were malignant. Microcalcifications correlated with malignancy only 30% of the time (12/42).
Married couples and cancer
Authors: Walach Natalio 
Published: February 2007

AbstractThe occurrence of cancer in 46 couples related only by marriage and treated in a regional hospital is reported. Twenty‐four pairs had tumors of the same histopathologic type. Three couples had the same tumors with similar histology: brain (astrocytoma), urinary bladder (transitional cell carcinoma), and lung (adenocarcinoma). The possible significance of environmental, nutritional, and contamination factors are emphasized, although this is a probably coincidental phenomenon.
Expression of ras oncogene p21 protein in esophageal squamous cell carcinoma
Authors: Ruol Alberto , Stephens Janet K. , Michelassi Fabrizio , Segalin Andrea , Chiarelli Silvia , Peracchia Alberto , Skinner David B. , Little Alex G. 
Published: February 2007

AbstractIn order to investigate the value of ras oncogene expression as a prognostic indicator in esophageal squamous cell carcinoma, we evaluated the level of ras oncogene protein product (p21) in 52 specimens resected between 1977 and 1986. All patients were followed until death or for at least 2 years. Pathology slides and archival paraffin blocks were retrieved for confirmation of the original diagnosis, study of histopathologic features, and measurement of p21 content. P21 titers were obtained using the RAP‐5 monoclonal antibody in a semiquantitative immunohistochemical assay. Titer was expressed as the highest dilution of antibody giving definitive staining using the avidin‐biotin peroxidase method. Ras oncpgene was expressed in 88.5% of the specimens. We did not find a significant correlation between ras expression and any of a variety of clinical and histopathologic prognostic parameters. Although patients' median survival after resection of specimens with ras oncogene expression was less than half the median survival after removal of tumors without such expression, this difference was not statistically significant. Further prospective investigations are needed to assess the role of ras oncogene evaluation in clinical practice.