bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-tissue transcriptome-wide association study identifies novel candidate susceptibility genes for cataract
Authors: Choquet Hélène , Duot Matthieu , Herrera Victor A. , Shrestha Sanjaya K. , Meyers Travis J. , Hoffmann Thomas J. , Sangani Poorab K. , Lachke Salil A. 
Published: April 2024

IntroductionCataract is the leading cause of blindness among the elderly worldwide. Twin and family studies support an important role for genetic factors in cataract susceptibility with heritability estimates up to 58%. To date, 55 loci for cataract have been identified by genome-wide association studies (GWAS), however, much work remains to identify the causal genes. Here, we conducted a transcriptome-wide association study (TWAS) of cataract to prioritize causal genes and identify novel ones, and examine the impact of their expression.MethodsWe performed tissue-specific and multi-tissue TWAS analyses to assess associations between imputed gene expression from 54 tissues (including 49 from the Genotype Tissue Expression (GTEx) Project v8) with cataract using FUSION software. Meta-analyzed GWAS summary statistics from 59,944 cataract cases and 478,571 controls, all of European ancestry and from two cohorts (GERA and UK Biobank) were used. We then examined the expression of the novel genes in the lens tissue using the iSyTE database.ResultsAcross tissue-specific and multi-tissue analyses, we identified 99 genes for which genetically predicted gene expression was associated with cataract after correcting for multiple testing. Of these 99 genes, 20 (AC007773.1, ANKH, ASIP, ATP13A2, CAPZB, CEP95, COQ6, CREB1, CROCC, DDX5, EFEMP1, EIF2S2, ESRRB, GOSR2, HERC4, INSRR, NIPSNAP2, PICALM, SENP3, and SH3YL1) did not overlap with previously reported cataract-associated loci. Tissue-specific analysis identified 202 significant gene-tissue associations for cataract, of which 166 (82.2%), representing 9 unique genes, were attributed to the previously reported 11q13.3 locus. Tissue-enrichment analysis revealed that gastrointestinal tissues represented one of the highest proportions of the Bonferroni-significant gene-tissue associations (21.3%). Moreover, this gastrointestinal tissue type was the only anatomical category significantly enriched in our results, after correcting for the number of tissue donors and imputable genes for each reference panel. Finally, most of the novel cataract genes (e.g., Capzb) were robustly expressed in iSyTE lens data.DiscussionOur results provide evidence of the utility of imputation-based TWAS approaches to characterize known GWAS risk loci and identify novel candidate genes that may increase our understanding of cataract etiology. Our findings also highlight the fact that expression of genes associated with cataract susceptibility is not necessarily restricted to lens tissue.
Adverse respiratory patterns in near-term spontaneously breathing newborn lambs with elevated airway liquid volumes at birth
Authors: Davies I. M. , Crossley K. J. , McGillick E. V. , Nitsos I. , Rodgers K. , Thiel A. , Zahra V. A. , Badurdeen S. , te Pas A. B. , Hooper S. B. 
Published: April 2024

IntroductionRecent evidence indicates that respiratory distress (RD) in near-term infants is caused by elevated airway liquid (EL) volume at the beginning of air-breathing after birth. While the adverse effects EL volumes on newborn lung function are known, the effects on respiratory control and breathing patterns shortly after birth (&lt;4 h) are unknown. We investigated the effects of EL volumes on cardiorespiratory function and breathing patterns in spontaneously breathing near-term newborn lambs in the first hours after birth.MethodsAt 137–8 days gestation (2–3 days prior to delivery; term ∼147 days), sterile surgery was performed on fetal sheep (n = 17) to implant catheters and blood flow probes. At 140 days, lambs were delivered via caesarean section under spinal anaesthesia. Airway liquid volumes were adjusted to mimic the level expected following vaginal delivery (∼10 ml/kg; Controls; n = 7), or elective caesarean section (∼30 ml/kg; elevated airway liquid group; EL; n = 10). Spontaneous breathing and cardiorespiratory parameters were recorded over four hours after birth. Non-invasive respiratory support with supplemental oxygen was provided if required.ResultsEL lambs required higher inspired oxygen levels (p = 0.0002), were less active (p = 0.026), fed less (p = 0.008) and had higher respiratory morbidity scores than Controls (p &lt; 0.0001). EL lambs also displayed higher rates of breathing patterns associated with RD, such as expiratory braking and tachypnoea. These patterns were particularly evident in male EL lambs who displayed higher levels of severe respiratory morbidity (e.g., expiratory braking) than female EL lambs.ConclusionThe study demonstrates that EL volumes at birth trigger respiratory behaviour and breathing patterns that resemble clinically recognised features of RD in term infants.
Post-COVID-19 cognitive symptoms in patients assisted by a teleassistance service: a retrospective cohort study
Authors: Bonfim Lívia Paula Freire , Correa Thais Rotsen , Freire Bruno Cabaleiro Cortizo , Pedroso Thais Marques , Pereira Daniella Nunes , Fernandes Thalita Baptisteli , Kopittke Luciane , Oliveira Clara Rodrigues Alves de , Teixeira Antonio Lucio , Marcolino Milena Soriano 
Published: April 2024

IntroductionFour years after the onset of the COVID-19 pandemic, the frequency of long-term post-COVID-19 cognitive symptoms is a matter of concern given the impact it may have on the work and quality of life of affected people.ObjectiveTo evaluate the incidence of post-acute COVID-19 cognitive symptoms, as well as the associated risk factors.MethodsRetrospective cohort, including outpatients with laboratory-confirmed COVID-19 and who were assisted by a public telehealth service provided by the Telehealth Network of Minas Gerais (TNMG), during the acute phase of the disease, between December/2020 and March/2022. Data were collected through a structured questionnaire, applied via phone calls, regarding the persistence of COVID-19 symptoms after 12 weeks of the disease. Cognitive symptoms were defined as any of the following: memory loss, problems concentrating, word finding difficulties, and difficulty thinking clearly.ResultsFrom 630 patients who responded to the questionnaire, 23.7% presented cognitive symptoms at 12 weeks after infection. These patients had a higher median age (33 [IQR 25–46] vs. 30 [IQR 24–42] years-old, p = 0.042) with a higher prevalence in the female sex (80.5% vs. 62.2%, p &lt; 0.001) when compared to those who did not present cognitive symptoms, as well as a lower prevalence of smoking (8.7% vs. 16.2%, p = 0.024). Furthermore, patients with persistent cognitive symptoms were more likely to have been infected during the second wave of COVID-19 rather than the third (31.0% vs. 21.3%, p = 0.014). Patients who needed to seek in-person care during the acute phase of the disease were more likely to report post-acute cognitive symptoms (21.5% vs. 9.3%, p &lt; 0,001). In multivariate logistic regression analysis, cognitive symptoms were associated with female sex (OR 2.24, CI 95% 1.41–3.57), fatigue (OR 2.33, CI 95% 1.19–4.56), depression (OR 5.37, CI 95% 2.19–13.15) and the need for seek in-person care during acute COVID-19 (OR 2.23, CI 95% 1.30–3.81).ConclusionIn this retrospective cohort of patients with mostly mild COVID-19, cognitive symptoms were present in 23.7% of patients with COVID-19 at 12 weeks after infection. Female sex, fatigue, depression and the need to seek in-person care during acute COVID-19 were the risk factors independently associated with this condition.
Interval training has more negative effects on sleep in adolescent speed skaters: a randomized cross controlled trial
Authors: Kong Zhenxing , Wei Xinhua , Shen Meng , Cheng Yue , Feng Junpeng 
Published: April 2024

ObjectiveSleep is an essential component of athletic performance and recovery. This study aimed to investigate the effects of different types of high-intensity exercise on sleep parameters in adolescent speed skaters.MethodsEighteen male adolescent speed skaters underwent aerobic capacity testing, Wingate testing, and interval training in a randomized crossover design to assess strength output, heart rate, and blood lactate levels during exercise. Sleep quality after each type of exercise was evaluated using the Firstbeat Bodyguard 3 monitor.ResultsThe results showed that Wingate testing and interval training led to decreased sleep duration, increased duration of stress, decreased RMSSD, and increased LF/HF ratio (p &lt; 0.01). Conversely, aerobic capacity testing did not significantly affect sleep (p &gt; 0.05). The impact of interval training on sleep parameters was more significant compared to aerobic capacity testing (p &lt; 0.01) and Wingate testing (p &lt; 0.01).ConclusionHigh-intensity anaerobic exercise has a profound impact on athletes’ sleep, primarily resulting in decreased sleep duration, increased stress duration, decreased RMSSD, and increased LF/HF ratio.
Evolution of logistics in the context of digital transformation: Common and profile barriers
Authors: Ponkratov-Vaysman B. D. 
Published: April 2024

Aim. To investigate the key barriers faced by enterprises in the process of digital transformation in the field of logistics, as well as to identify the profile barrier inherent in logistics processes and offer practical recommendations for overcoming them. Objectives. To analyze the development of digital transformation and the impact on the processes of Logistics; to identify the process-barrier relationship; to identify the key barriers arising in the digital transformation at enterprises, including the profile barrier in the processes of logistics; to offer practical recommendations for overcoming barriers in the aspect of the implementation of digital initiativesMethods. The research is based on multidisciplinary analysis of academic and professional literature, reports of consulting companies, as well as consideration of practical cases from the industry.Results. An Ishikawa diagram was developed to capture the process-barrier relationship and identification of key barriers arising from digital transformation in logistics enterprises. The profile barrier was identified, in particular the complexity of logistic processes. Recommendations for overcoming barriers in the course of digital transformation at the enterprise were developed.Conclusions. Digital transformation is important for maintaining competitiveness and development of enterprises, including in the field of logistics. Effective implementation of digital solutions requires both technological and organizational changes. When carrying out digital transformation of enterprises in the field of logistics, one of the key factors of efficiency is the consideration of the profile barrier, i.e. the complexity of logistic processes. Analyzing the impact of all potential barriers of digital transformation, taking into account the specifics of the enterprise’s activities will eventually allow to carry out digital transformation with the greatest efficiency.
PENYULUHAN PEMANFAATAN MEDIA SOSIAL SEBAGAI MEDIA INTERAKSI DAN PROMOSI PADA ANGKRINGAN JOGJA PADANGSAMBIAN
Authors: Setyarini Putu , Muryatini Ni Nyoman , Gede Lamopia I Wayan , Yuningsih Lilis , Wulandari Riza , Nila Dewi Nyoman Ayu 
Published: April 2024

Melihat pengaruh dari media digital dan komunikasi global yang terjadi saat ini, penting untuk diadakan penyuluhan tentang inovasi strategi promosi dan media interaksi secara verbal dan visual yang tertuang pada media sosial. Angkringan yang terletak di Denpasar ini pada awalnya melakukan bentuk promosi bersifat konvensional dan mengandalkan pelanggan datang ke angkringan saja. Cukup tergolong khas, karena cita rasa yang disajikan masih seperti orang Jogja. Hingga akhirnya angkringan ini menjadi salah satu tempat peralihan rindu akan kampung halaman dengan tradisi ngopi. Pengabdian ini dilaksanakan dengan tujuan memberikan peluang dan kesempatan usaha tradisional Angkringan Jogja untuk terus eksis dan bertahan dengan memanfaatkan media sosial sebagai bentuk media promosi dan interaksi dengan pelaku digital. Hasil dari kegiatan ini adalah peningkatan pemahaman tentang media sosial serta prospek jangka panjang untuk Angkringan Jogja yang dapat melakukan interaksi yakni berkomunikasi dengan para pelanggan Angkringa Jogja terkait informasi menu jam operasional, kondisi pengunjung angkringan. Pada promosi dapat dilakukan mengunggah menu baru, kondisi pengunjung angkringan yang menjadikan daya tarik para pelaku digital.
Fatigue its Related Factors and Quality of Life among Patients with Heart Failure in Tertiary Care Hospital Kochi
Authors: Akhil C S  , Kanmani J  , Rajesh Thachathodiyil  , Naveen Mathew  
Published: April 2024

Background: Heart failure (HF) is a common disease caused by inability of the heart to pump for supporting the circulation and the functional abnormalities of the heart. The present study was designed to assess the Fatigue, its related factors and Quality of life (QoL) among Patients with HF in Tertiary Care Hospital, Kochi with the objectives to (1) Find out the correlation between fatigue and (QoL) among patients with HF. (2) Identify the related factors among patients with HF. (3) Find the correlation between fatigue and its related factors among patients with HF.Methods: A cross sectional design with non-probability convenience sampling technique was used to collect data from 150 HF patients from cardiology OPD at AIMS, Kochi. A standardized MFI, PSQI, HADS, MLHFQ tool were used for the assessment of fatigue, sleep, anxiety, depression, and QoL. The emotional aspects of QoL is significantly correlated with general fatigue (p=0.026), physical fatigue (p=0.004) and reduced motivation (< 0.001). The correlation with depression and dimensions of fatigue was found to be significant as the p-value was less than 0.05..Conclusion: The study concludes that the general fatigue level increases the QoL decrease. General and mental fatigue increases the depression also increases.
Co-occurring dominance and ideal point processes: A general IRTree framework for multidimensional item responding
Authors: Merhof Viola , Meiser Thorsten 
Published: April 2024

AbstractResponding to rating scale items is a multidimensional process, since not only the substantive trait being measured but also additional personal characteristics can affect the respondents’ category choices. A flexible model class for analyzing such multidimensional responses are IRTree models, in which rating responses are decomposed into a sequence of sub-decisions. Different response processes can be involved in item responding both sequentially across those sub-decisions and as co-occurring processes within sub-decisions. In the previous literature, modeling co-occurring processes has been exclusively limited to dominance models, where higher trait levels are associated with higher expected scores. However, some response processes may rather follow an ideal point rationale, where the expected score depends on the proximity of a person’s trait level to the item’s location. Therefore, we propose a new multidimensional IRT model of co-occurring dominance and ideal point processes (DI-MIRT model) as a flexible framework for parameterizing IRTree sub-decisions with multiple dominance processes, multiple ideal point processes, and combinations of both. The DI-MIRT parameterization opens up new application areas for the IRTree model class and allows the specification of a wide range of theoretical assumptions regarding the cognitive processing of item responding. A simulation study shows that IRTree models with DI-MIRT parameterization provide excellent parameter recovery and accurately reflect co-occurring dominance and ideal point processes. In addition, a clear advantage over traditional IRTree models with purely sequential processes is demonstrated. Two application examples from the field of response style analysis highlight the benefits of the general IRTree framework under real-world conditions.
Rol de la enfermería en la atención del adulto mayor en unidades de salud familiar de la ciudad de Pilar, 2024
Authors: Ríos Paredes Melva Jazmín 
Published: April 2024

El rol del enfermero en el cuidado de adultos mayores es fundamental para asegurar la calidad de vida y bienestar. Los enfermeros desempeñan un papel crucial en la atención integral, la gestión de enfermedades crónicas, la promoción de la autonomía y apoyo emocional, contribuyendo al envejecimiento saludable y digno. En esta investigación se pretendió describir el rol de la enfermería en la atención del adulto mayor en las unidades de salud familiar de la ciudad de Pilar, 2024. Se realizó una revisión de la literatura mediante el portal CICCO y Google Académico, que se amplió con una metodología cuyo tipo de investigación fue descriptiva, enfoque mixto, de corte trasversal. La poblacion de estudio fueron 9 (nueve) Unidades de Salud familiar de Pilar; se realizó el cálculo de muestreo aleatorio estratificado con afijación proporcional para determinar una muestra representativa lo cual arrojón una muestra de 332 (trescientos treinta y dos) pacientes, 2 (dos) doctores y 3 (tres) enfermeros. Los principales resultados indican aspectos positivos en concordancia con el rol del enfermero, como la atención a la respiración y movilidad, pero sugieren mejoras en la regularidad y consistencia. Las recomendaciones de los enfermeros destacan compromiso en promoción de salud y colaboración interdisciplinaria, aunque se sugiere estandarizar prácticas. En general, se observa atención de calidad con espacio para mejora en las USF de Pilar.
Amitié et amour : passages
Authors: Ducousso-Lacaze Alain 
Published: April 2024

Partant de son expérience clinique, l’auteur s’interroge sur des situations particulières d’homoparentalité. Il s’agit de celles où deux amis, un homme et une femme, se mettent d’accord pour faire un enfant ensemble, puis l’élever sans s’engager dans une vie conjugale. Le lien reste-t-il un lien d’amitié ? Une dimension pulsionnelle généralement attribuée à l’amour ne vient-elle pas s’en mêler ? L’auteur propose des réponses à ces questions en appui sur un entretien clinique de recherche auprès d’un homme engagé dans cette forme de parentalité. Il met en évidence comment, avec le devenir-parent, le lien d’amitié est traversé par les enjeux d’une scène primitive hétérosexuelle mais aussi par une actualisation des enjeux œdipiens et soumis aux exigences de la filiation instituée et de la filiation fantasmatique.
Michael A. Gilbert: Not arguing logically is not illogical: Other ways of communicating arguments
Authors: Gilbert Michael A. , Carozza Linda 
Published: April 2024

Michael A. Gilbert has contributed significantly to the field of contemporary Argumentation Theory. Most notable are his multi-modal theory of argumentation and coalescent argumentation, models of argument that he developed to address how interlocutors actually argue in the marketplace. His ideas were not always understood, appreciated, or acknowledged by the larger argumentation community. Recently, though, the Centre for Research in Reasoning, Argumentation & Rhetoric (in Ontario, Canada) recognized Gilbert’s contributions in a week-long Institute dedicated to his scholarship. Provoking as his theories might seem, rhetorical scholars can find some common ground with Gilbert’s works.
Christopher Tindale : Explorer les fondements culturels de la rhétorique et de la raison
Authors: Tindale Christopher , Amossy Ruth 
Published: April 2024

L’entretien mené avec Christopher Tindale par Ruth Amossy dans ce numéro spécial sur les défis lancés à la rhétorique propose un tour d’horizon du travail innovant du chercheur canadien. Passant de la logique informelle à une théorie de l’argumentation rhétorique, Tindale aboutit finalement à une approche anthropologique qui met au défi la tradition rhétorique occidentale. Cette approche part du principe que les modes de raisonnement dépendent de la culture et que les arguments, en tant qu’expression de la raison, peuvent prendre de nombreuses formes au-delà de celles que repère et décrit la tradition occidentale. Tindale aborde donc la question de la communication interculturelle dans sa dimension argumentative. Dans ce cadre, il présente une « rhétorique de la rencontre » qui explore la rencontre entre des personnes issues de cultures très différentes et examine comment un environnement cognitif mutuel peut, au fil du temps, émerger et permettre un échange argumentatif.
Steve Oswald: Pragmatics and rhetoric
Authors: Oswald Steve , Herman Thierry 
Published: April 2024

Does the search for perlocutionary effectiveness (getting people to agree with a claim, to buy a product, etc.) without truth or morality playing a decisive role constitute what some call manipulation? Precisely because he is interested in the mechanisms of persuasion, Steve Oswald has woven links between cognitive science and rhetoric around this notion. Drawing on theories of cognitive pragmatics and work in psychology, this researcher goes off the beaten track of rhetoric by opening what is for many a black box: the question of the effects of discursive strategies. He has approached this question first by attempting to explain the mechanism theoretically, but more recently also experimentally. Examining the question of rhetorical effects in this way makes it possible not only to revitalise the discipline by documenting the intuitions or empirical findings of the old rhetoricians, but also to build bridges between approaches that sometimes ignore each other: informal logic, cognitive psychology, cognitive pragmatics, and discourse analysis.
L’imaginaire socio-discursif de « la femme africaine » dans le discours des dirigeants politiques français
Authors: Mejdoubi Sara 
Published: April 2024

Les représentations de la « femme africaine » ne sont pas neutres. Elles sont révélatrices d’un certain positionnement sur les femmes de cette partie du monde. Cet article propose d’analyser le syntagme de « femme africaine » et ses variantes, comme imaginaire socio-discursif, dans les discours politiques-diplomatiques français. A partir de la démarche de l’Analyse du Discours, nous examinons les savoirs d’opinion qui continuent d’affecter l’image des femmes du continent africain. Une attention particulière est accordée à un corpus constitué de discours des politiques français, prononcés dans différents contextes et en lien avec des contraintes discursives variées. Il s’agit de montrer comment s’est constitué la « femme africaine » comme imaginaire, ses modes de circulation au sein des groupes sociaux et, enfin, la manière dont les dirigeants politiques l’utilisent dans leurs discours. Cet usage opère un ensemble de catégorisations, maintenant la « femme africaine » dans des imaginaires sociaux en rupture avec les réalités de l’Afrique.