bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ru2M(dpa)4Cl2 (M = Cu, Ni): Synthesis, Characterization, and Theoretical Analysis of Asymmetric Heterometal String Complexes of the Dipyridylamide Family
Authors: Huang Gin‐Chen , Bénard Marc , Rohmer Marie‐Madeleine , Li Long‐An , Chiu Mei‐Jyun , Yeh Chen‐Yu , Lee Gene‐Hsiang , Peng Shie‐Ming 
Published: March 2008

AbstractFour heterotrinuclear strings of metal atoms stabilized by dipyridylamide (dpa–) ligands were synthesized and characterized. The metal frameworks of Ru2Cu(dpa)4Cl2 (1), its monooxidized counterpart [Ru2Cu(dpa)4Cl2]PF6 (2), and their nickel homologues, Ru2Ni(dpa)4Cl2 (3) and [Ru2Ni(dpa)4Cl2]PF6 (4), were shown by X‐ray diffraction to be nonsymmetric, in spite of a severe disorder affecting the metal positions. The metal string is composed of a Ru dimer with a short Ru–Ru bond that is completed with the heterometal at a longer distance from the central ruthenium atom. This nonsymmetric structure was confirmed from NMR spectroscopy. The [Ru2M]6+ framework of 1 and 3 was shown from spectroelectrochemical analysis and DFT calculations to exist in the form of a mixed‐valent [Ru2]5+ moiety coupled to a formally M+ heterometal. The temperature‐dependant magnetic susceptibility of these compounds is reported and interpreted by means of a model previously applied to [Ru2]5+ complexes. The redox chemistry of 1 and 3 was investigated by cyclic voltammetry, and the electronic structure of the mono‐ and dioxidized species was assigned from the observed changes in the UV/Vis spectra and from DFT calculations.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Preparation and Crystal Structures of ­Purine 2,2′‐, 6,6′‐, and 8,8′‐Dimers
Authors: Tobrman Tomáš , Štěpnička Petr , Císařová Ivana , Dvořák Dalimil 
Published: March 2008

AbstractTreatment of 9‐ or 7‐substituted 6‐, 2‐, or 8‐iodopurine derivatives with copper(I) thiophene‐2‐carboxylate or copper(I) 3‐methylsalicylate in N,N‐dimethylformamide affords the corresponding 6,6′‐, 2,2′‐, and 8,8′‐purine dimers in high yield. Cross‐dimerization reactions of different iodo derivatives were attempted, but only mixtures containing the cross‐coupled products, homodimers, or dehalogenation products were obtained. The crystal structures of 9,9′‐dibenzyl‐ (1a) and 9,9′‐bis(1‐methylethyl)‐9H,9′H‐[6,6′]bipurinyl (1c) and the salt [1aH2]Br2 were determined by single‐crystal X‐ray diffraction analysis, which revealed extensive hydrogen bonding and π···π stacking interactions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Thermal properties and fire behaviour of materials produced from curing mixed epoxy and phenolic resins
Authors: Laza J. M. , Bilbao E. , Garay M. T. , Vilas J. L. , Rodríguez M. , León L. M. 
Published: March 2008

AbstractThermal stability and fire behaviour of materials obtained from curing mixed epoxy and phenolic resins have been studied, the decomposition processes being compared with those for the pure resins. Samples were cured by triethylenetetramine or p‐toluenesulphonic acid by isothermal pressing at 90∘C, and decompositions were carried out under nitrogen and air environment from 50 to 1000∘C. Only for mixtures with higher proportion of epoxy resin, the decomposition process goes through a unique step as for the pure resin. Results from fire tests indicated that mixtures are classified as M3 and F1. Copyright © 2008 John Wiley & Sons, Ltd.
Pricing and hedging illiquid energy derivatives: An application to the JCC index
Authors: Scarpa Elisa , Manera Matteo 
Published: March 2008

AbstractIn this paper a simple strategy for pricing and hedging a swap on the Japanese crude oil cocktail (JCC) index is discussed. The empirical performance of different econometric models is compared in terms of their computed optimal hedge ratios, using monthly data on the JCC over the period January 2000–January 2006. An explanation to how to compute a bid/ask spread and to construct the hedging position for the JCC swap contract with variable oil volume is provided. The swap pricing scheme with backtesting and rolling regression techniques is evaluated. The empirical findings show that the price‐level regression model permits one to compute more precise optimal hedge ratios relative to its competing alternatives. © 2008 Wiley Periodicals, Inc. Jrl Fut Mark 28:464–487, 2008
Amplification of 11q13 in ovarian carcinoma
Authors: Brown Lindsay A. , Kalloger Steve E. , Miller Melinda A. , Shih Ie‐Ming , McKinney Steven E. , Santos Jennifer L. , Swenerton Ken , Spellman Paul T. , Gray Joe , Gilks C. Blake , Huntsman David G. 
Published: March 2008

AbstractAmplification at the 11q13 locus is commonly observed in breast, ovarian, head and neck, oral, and esophageal cancer. Studies of this region led to the identification of multiple amplicons containing several potential oncogenes including EMSY, PAK1, RSF1, and GAB2. Here, we investigate the amplification of the above four genes and their prognostic significance in histologically and clinically defined subsets of ovarian cancer. Amplification of all four genes was assessed by fluorescent in situ hybridization in tissue microarrays containing 538 clinically annotated ovarian carcinomas with 12 years of follow‐up data. Overall, for the entire cohort, EMSY was amplified in 44 (16%) of 269 cases, PAK1 was amplified in 38 (15%) of 255 cases, RSF1 was amplified in 37 (12%) of 310 cases, and GAB2 was amplified in 41 (16%) of 255 cases. Amplification of EMSY, PAK1, RSF1, and GAB2 were all highly correlated with each other and with a serous histology. Univariate survival analysis showed that tumors with EMSY and RSF1 amplification were associated with a significantly worse outcome. A molecular inversion probe array was then used to study the 11q13 amplicon in 33 high grade serous carcinomas. The core of the amplicon mapped to a 6‐Mb region encompassing EMSY, PAK1, RSF1, and GAB2. However, a second more telomeric amplicon was also observed for which no candidate genes have been identified. In summary, amplification of these four putative oncogenes from 11q13 in early ovarian cancer is associated with a serous histology and in the case of EMSY and RSF1 a poor outcome. These findings support the hypothesis that the11q13 amplicon in ovarian cancer is likely driven by a cassette of genes rather than by a single oncogene. This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045‐2257/suppmat. © 2008 Wiley‐Liss, Inc.
Erratum: Effectiveness of health management departments of universities that train health managers in Turkey (p 263–288)
Authors: Karagoz Sevgul , Balci Ali 
Published: March 2008

AbstractInt J Health Plann Mgmt 2007; 22: 263‐‐288.DOI: 10.1002/hpm.854The Editor‐In‐Chief would like to apologise for the quality of this paper as published in the present form in The International Journal of Health Planning and Management. A corrected version should have been submitted; the earlier version unfortunately was submitted for publication.Reproduced below is the corrected Summary.SUMMARYThis research has aimed to examine the effectiveness of the health management departments of universities which train health managers in Turkey. The study compares ‐ for lecturers and students ‐ nine variables of organisational effectiveness. These nine dimensions are derived from Cameron (1978; 1981; 1986). Factor analysis was used to validate the scale developed by the researcher. For internal consistency and reliability, the Cronbach Alpha reliability coefficient and item total correlation were applied. A questionnaire was administered to a total of 207 people in health management departments in Turkey. In analysis of the data, descriptive statistics and the t‐test were used. According to our research findings, at individual university level, lecturers found their departments more effective than did their students. The highest effectiveness was perceived at Baskent University, a private university. The best outcome was achieved for ‘organisational health’, and ‘the ability to acquire resources’ achieved the lowest outcome. Effectiveness overall was found to be moderate. Copyright © 2006 John Wiley & Sons, Ltd.Apologies to the authors and readers for any inconvenience caused.
Comparison of PEI‐PEG and PLL‐PEG copolymer coatings on the prevention of protein fouling
Authors: Bergstrand Anna , Rahmani‐Monfared Ghazal , Östlund Åsa , Nydén Magnus , Holmberg Krister 
Published: March 2008

AbstractThe effect of surface charge on the protein resistance of adsorbed layers of poly(ethylene imine)‐[g]‐poly(ethylene glycol), PEI‐PEG, and poly(L‐lysine)‐[g]‐poly(ethylene glycol), PLL‐PEG, was studied. Mixed and monofunctional self‐assembled monolayers, SAMs, on gold were obtained by adsorption of 16‐mercapto‐1‐hexadecanoic acid and 16‐mercapto‐1‐hexadecanol. The surface charge was systematically varied by changing the ratio of the two alkanethiols. The graft copolymers PEI‐PEG and PLL‐PEG were adsorbed at the SAMs and tested for resistance towards human serum albumin and fibrinogen. The adsorbed amount of copolymers increased with increasing negative surface charge. However, the best protein resistance was found at an intermediate surface charge. The PLL‐PEG covered surfaces showed better protein resistance than the PEI‐PEG covered surfaces. Thus, this work demonstrates that an adsorbed layer of PEG‐grafted PEI and, in particular, PEG‐grafted PLL is efficient in preventing protein adsorption when there is charge neutralization between the copolymer and the underlying surface. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009
Multilayer composite scaffolds with mechanical properties similar to small intestinal submucosa
Authors: Lawrence Benjamin J. , Maase Eric L. , Lin Hsueh‐Kung , Madihally Sundararajan V. 
Published: March 2008

AbstractUse of biodegradable scaffolds to engineer new tissues has become an attractive option in various transplantation protocols. In particular, small intestinal submucosa (SIS) has generated immense interest in various tissue engineering applications because of its diverse favorable properties. However, it is a natural matrix, which leads to problems in large‐scale preparations and contains sample to sample heterogeneity. In this study, we explored the formation of synthetic matrix mimicking the characteristics of the SIS. Three‐dimensional composite structures were developed by sandwiching 50:50 PLGA film between porous chitosan matrices. The outer chitosan layers provide biological activity while the inner PLGA layer provides mechanical strength. PLGA films were initially perforated at 1 cm distance, and the porous chitosan matrix was formed sequentially on each side by controlled rate freezing and lyophilization technique at −80°C. Scanning electron microscopy analysis showed a layered microarchitecture with chitosan filling the perforations of PLGA membrane. Urea permeability studies confirmed that the perforations were filled (negligible urea transfer across composite over 8 h). Tensile strength analysis showed that the matrices formed using 160 kDa PLGA had sufficient break stress (∼4.5 MPa). Degradation analysis over 8 weeks in the presence of 10 mg/L lysozyme showed a 50% decrease in total weight and an 80% decrease in PLGA molecular weight. When cellular adhesion and actin distribution of mouse embryonic fibroblasts were evaluated, for 7 days, cells showed their typical spindle shape and redistribution of actin fibers on composite matrices. Viability studies and MMP‐2/MMP‐9 activity showed that the cells were viable and functional, similar to tissue culture plastic. Further, canine bladder smooth muscle cells also showed similar cell adhesion and spreading on the composite matrix. In summary, composite structures mimicking SIS were constructed and show potential as a tissue engineering material. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009
Dislocation identification and in situ straining in the spinodal Fe30Ni20Mn25Al25 alloy
Authors: Loudis J.A. , Baker I. 
Published: March 2008

AbstractDislocations in the spinodal alloy Fe30Ni20Mn25Al25, which is composed of alternating BCC and B2 (ordered BCC) phases, have been investigated using weak‐beam transmission electron microscopy (TEM). The alloy was compressed at room temperature in an as‐hot‐extruded state to strains of ∼3% for post‐mortem dislocation analysis. Dislocations with a/2〈111〉 Burgers vectors were found to glide in pairs on both {110} and {112} slip planes. TEM in situ straining experiments were also performed on both the as‐extruded alloy and an arc‐melted alloy. The in situ straining observations confirmed that dislocations were able to pass between both spinodal phases. Partial dislocation separations were relatively wide in the BCC phase and narrow in the B2 phase. Dislocation glide, as opposed to twinning (both of which have been observed in other BCC‐based spinodals), was also found to be the only room temperature deformation mechanism. Microsc. Res. Tech., 2008. © 2008 Wiley‐Liss, Inc.
First‐trimester maternal serum progesterone in aneuploid pregnancies
Authors: Christiansen Michael , Sørensen Tina Lindvig , Larsen Severin Olesen , Nørgaard‐Pedersen Bent 
Published: March 2008

AbstractBackgroundFirst‐trimester maternal serum screening for Down syndrome (DS) can be improved by the use of additional serum markers. We examined whether progesterone (P), synthesized by placenta, might be a first‐trimester maternal serum marker for fetal DS.Materials and MethodsP was quantified in first‐trimester maternal serum from 42 DS, six trisomy 18 and two trisomy 13 pregnancies and 115 controls. Log‐regression of P versus gestational age in days was used to convert P concentrations into multiples of the median (MoM).ResultsThe P concentrations in controls increased with gestational age (p = 9.5 × 10−7). The log10MoM P distribution in DS pregnancies was not significantly different from that in controls. However, from day 58–67, the log10MoM P was elevated in DS pregnancies (n = 10) with a mean (SD) of 0.1040 (0.0956), compared to a mean (SD) of − 0.0109 (0.1661) in controls (n = 24) (p = 0.05). Five out of six trisomy 18 and both trisomy 13 pregnancies had a P MoM < 1.ConclusionP is not a useful marker for DS in first trimester, except perhaps in a narrow gestational age window from day 58 to 67. P is a trisomy 18/13 marker. Copyright © 2008 John Wiley & Sons, Ltd.
First trimester screening for Down syndrome in rhesus negative women
Authors: Muhcu Murat , Mungen Ercument , Atay Vedat , Ipcioglu Osman Metin , Dundar Ozgur , Ergur Rustu , Yergok Yusuf Ziya 
Published: March 2008

AbstractObjectivesTo explore the effect of maternal rhesus status on first‐trimester screening markers for Down syndrome.MethodsWe accessed a database of singleton pregnancies undergoing first‐trimester genetic screen with maternal Rh status documented and pregnancy outcome information available. Excluded were cases of fetal chromosomal or structural abnormalities, or maternal systemic disease. Results of maternal serum pregnancy‐associated plasma protein A (PAPP‐A) and β‐human chorionic gonadotrophin (β‐hCG) adjusted for gestational age were compared between Rh‐negative and Rh‐positive women with p < 0.05 considered significant.ResultsTwo thousand two hundred and two pregnancies fulfilled the study criteria, and 160 of them (7%) were Rh negative. Only free β‐hCG corrected multiples of the median (MoM) values were statistically increased in Rh‐negative women (p < 0.009). Using a cut‐off of 1:300, screen‐positive rates of maternal serum biochemistry were not significantly different between Rh‐negative and Rh‐positive women (12.5 vs 10.4%, p = 0.41).ConclusionThe present study focused on measurements of β‐hCG and PAPP‐A in the sera of women with Rh‐negative blood group. Women with Rh‐negative blood type have similar first‐trimester serum PAPP‐A MoM values as Rh‐positive women, but significantly higher β‐hCG MoM values. However, there was no significant difference in the screen‐positive rate for Down syndrome between the two groups. Copyright © 2008 John Wiley & Sons, Ltd.
Proteome analysis of aflatoxin B1‐induced hepatocarcinogenesis in tree shrew (Tupaia belangeri chinensis) and functional identification of candidate protein peroxiredoxin II
Authors: Li Yuan , Qin Xue , Cui Jiefeng , Dai Zhi , Kang Xiaonan , Yue Haiying , Zhang Yu , Su Jianjia , Cao Ji , Ou Chao , Yang Chun , Duan Xiaoxian , Yue Huifen , Liu Yinkun 
Published: March 2008

AbstractIn order to explore the proteins responsible for hepatocellular carcinoma (HCC), aflatoxin B1‐induced hepatocarcinogenesis in tree shrew (Tupaia belangeri chinensis) was analyzed with 2‐DE and MS. By comparing HCC samples with their own precancerous biopsies and HCC‐surrounding tissues, a group of candidate proteins that differentially expressed in HCC were obtained. Peroxiredoxin (Prx) II, one of the candidates with distinct alteration, was further investigated and validated. Western blot and RT‐PCR assays confirmed the overexpression of Prx II in both tree shrew and human HCC tissues. RNA interference for silencing Prx II was employed subsequently to explore the function and underlying mechanism of Prx II on liver cancer cell line Hep3B. Results showed the cell proliferation and clone formation decreased obviously when Prx II expression was inhibited, while the flow cytometer analysis showed the percentage of cell apoptosis enhanced. Inhibition of Prx II expression also obviously increased the generation of ROS and malondialdehyde, both are the products from peroxidation. These results imply the important role of Prx II in hepatocarcinogenesis, possibly through its function in regulating peroxidation and hereby to provide a favorable microenvironment for cancer cell surviving and progressing.
6th HUPO Annual World Congress – Proteomics Standards Initiative Workshop 6–10 October 2007, Seoul, Korea
Authors: Orchard Sandra , Martens Lennart , Tasman Joshua , Binz Pierre‐Alain , Albar Juan Pablo , Hermjakob Henning 
Published: March 2008

AbstractThe plenary session of the Proteomics Standards Initiative of the Human Proteome Organisation at the 6th annual HUPO world congress updated the delegates on the current status of the ongoing work of this group. The new MS interchange format, mzML, had been entered into the HUPO document process immediately prior to the meeting and was already under active discussion by prospective users. It is anticipated this will become the de facto standard in this area in 2008. Minimal requirements documents are in the process of being published and proteomics journals are beginning to request data deposition as part of the manuscript submission process. The session ended with a lively debate on the practical implications these advances will have on daily laboratory work, on submission procedures and the tools which are being developed to assist in these activities.
Proteomics Data Collection – 2nd ProDaC Workshop 5 October 2007, Seoul, Korea
Authors: Eisenacher Martin , Hardt Tanja , Hamacher Michael , Martens Lennart , Häkkinen Jari , Levander Fredrik , Apweiler Rolf , Meyer Helmut E. , Stephan Christian 
Published: March 2008

AbstractProteomics Data Collection (ProDaC) is an EU‐funded “Coordination Action” within the 6th framework programme. It aims to simplify the publication, dissemination and utilization of proteomics data by establishing standards that will support broad data collection from the research community. As a part of ProDaC, regular workshops are organized on a half‐yearly basis to enable communication and discussion of the involved partners and to report on project progress. After the kick‐off meeting (October 2006) in Long Beach, CA, USA and the 1st workshop in Lyon, France (April 2007), the 2nd ProDaC workshop took place at the COEX InterContinental Hotel in Seoul, Korea, on 5th October 2007, shortly before the HUPO World Congress. The progress achieved within the first year was presented by the leaders of the work packages. Additionally, a Journal's representative talked about his experiences and future plans concerning Proteomics standards; and two further external speakers presented their research related to data handling and Proteomics repositories.
Disease proteomics of endocrine disorders revealed by two‐dimensional gel electrophoresis and mass spectrometry
Authors: Oh‐Ishi Masamichi , Kodera Yoshio , Furudate Sen‐ichi , Maeda Tadakazu 
Published: March 2008

AbstractEndocrine disorders such as dwarfism and diabetes show abnormalities in many different organs even if a certain hormone is the primary cause of the disease. One of the aims of proteomics is to elucidate an abnormal hormone network underlying dysfunction in the disease through quantitative and qualitative proteome analyses of various organs. In a comprehensive study of the rdw rat with hereditary dwarfism, we found the accumulation of ER proteins in the rdw thyroid. Contrary to the initial notion that the dwarfism of the rat was caused by genetic mutations related to pituitary hormones, the primary cause is a missense mutation in the thyroglobulin gene. To understand at the protein level cellular damage caused by oxidative stress, we developed a proteomic method and applied to detecting protein carbonyls in various organs of a diabetes model OLETF rat. The method would provide a means toward clarifying a comprehensive view of oxidative modifications of proteins in diabetes. We review 2‐DE‐based disease proteomics of endocrine disorders in general, with particular attention paid to our proteome projects by a 2‐DE method with an agarose IEF gel in the first dimension (agarose 2‐DE) and LC‐MS/MS.
Clinical proteomics of the cerebrospinal fluid: Towards the discovery of new biomarkers
Authors: Roche Stéphane , Gabelle Audrey , Lehmann Sylvain 
Published: March 2008

AbstractThe cerebrospinal fluid (CSF) circulates within the CNS where it plays an essential physiological role in homeostasis of neuronal cells. This biological fluid has an important protein diversity that results from both filtration of serum through the blood–brain barrier and production/secretion of neuronal peptides and proteins. Changes in CSF composition depend on blood proteome, CSF circulation alterations, as well as physiological or pathological brain status. Hence, CSF proteomic analysis gives a unique opportunity to detect and describe biomarkers in neurological affections. Although lumbar puncture is considered as invasive, post lumbar puncture events remain rare and minor. Nevertheless, CSF biological analysis is currently limited to a small number of parameters and clinical situations suggesting mainly meningitis, malignancies or dementia. Few CSF proteomic studies have been performed in comparison to those on blood. In this review, we will provide a proteomics description of the CSF, summarize the current clinical use of this fluid and describe its clinical proteomics examination.