bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social support during intensive care unit stay might improve mental impairment and consequently health-related quality of life in survivors of severe acute respiratory distress syndrome
Authors: Deja Maria , Denke Claudia , Weber-Carstens Steffen , Schröder Jürgen , Pille Christian E , Hokema Frank , Falke Konrad J , Kaisers Udo 
Published: October 2006

Abstract
Introduction
We investigated health-related quality of life (HRQoL) and persistent symptoms of post-traumatic stress disorder (PTSD) in long-term survivors of acute respiratory distress syndrome (ARDS). We wished to evaluate the influence of PTSD on HRQoL and to investigate the influence of perceived social support during intensive care unit (ICU) treatment on both PTSD symptoms and HRQoL.

Methods
In ARDS patients we prospectively measured HRQoL (Medical Outcomes Study 36-Item Short Form; SF-36), symptoms of PTSD (Post-Traumatic Stress Syndrome 10-Questions Inventory; PTSS-10), perceived social support (Questionnaire for Social Support; F-Sozu) and symptoms of psychopathology (Symptom Checklist-90-R); and collected sociodemographic data including current employment status. Sixty-five (50.4%) out of 129 enrolled survivors responded, on average 57 ± 32 months after discharge from ICU. Measuring symptoms of PTSD the PTSS-10 was used to divide the ARDS patients into two subgroups ('high-scoring patients', indicating patients with an increased risk for developing PTSD, and 'low-scoring patients').

Results
HRQoL was significantly reduced in all dimensions in comparison with age- and gender-adjusted healthy controls. Eighteen patients (29%) were identified as being at increased risk for PTSD. PTSD risk was significantly linked with anxiety during their ICU stay. In this group of patients there was a trend towards permanent or temporary disability, independent of the period between discharge from ICU and study entry. Perceived social support was associated with a reduction in PTSD symptoms (Pearson correlation; p < 0.05). Post-hoc test revealed a significant difference between 'high-scoring patients' and 'low-scoring patients' with respect to mental health, although they did not differ in physical dimensions.

Conclusion
HRQoL was reduced in long-term survivors, and was linked with an increased risk of chronic PTSD with ensuing psychological morbidity. This was independent of physical condition and was associated with traumatic memories of anxiety during their ICU stay. Social support might improve mental health and consequently long-term outcome including employment status.
Clinicopathologic Characteristics and Outcome of Diffuse Large B-Cell Lymphomas Presenting With an Associated Low-Grade Component at Diagnosis
Authors: Ghesquières Hervé , Berger Françoise , Felman Pascale , Callet-Bauchu Evelyne , Bryon Paul-André , Traverse-Glehen Alexandra , Thieblemont Catherine , Baseggio Lucile , Michallet Anne-Sophie , Coiffier Bertrand , Salles Gilles 
Published: October 2006

Purpose Some diffuse large B-cell lymphomas (DLBCL) present at diagnosis with associated morphologic features of small B-cell non-Hodgkin's lymphoma (NHL) and may arise from the transformation of a previously unknown indolent low-grade lymphoma. The characteristics and prognosis of these particular DLBCL are not well known. Patients and Methods The strict morphologic review of consecutive DLBCL patients diagnosed over 12 years in our department (Hematology Department, Centre Hospitalier Lyon-Sud, Lyon, France) allowed to retrieve 60 DLBCL that could be have occurred from the transformation of marginal zone B-cell NHL (32 patients), follicular NHL (22 patients), and small lymphocytic NHL (6 patients). We compared them to 180 matched patients of de novo DLBCL. Results Patients median age was 55 years and presented the following clinical characteristics: poor performance status in 33%, disseminated disease in 97%, more than one extranodal site in 50%, and increased lactate dehydrogenase level in 55%. Complete remission with multidrug chemotherapy regimens was achieved in 60% of the patients, but 48% relapsed: 28% with aggressive and 20% with indolent histology, respectively. Overall survival (OS) and freedom-from-progression rates at 5 years were 57% and 33%, respectively. The matched-control analysis showed that patients with transformed NHL at diagnosis had lower complete response to chemotherapy (P = .004) and higher progression rate (P = .03), whereas no difference was observed in OS (P = .21). Conclusion Compared to de novo DLBCL, transformed NHL at diagnosis have similar overall survival but lower complete response to initial treatment and higher risk of indolent relapses.
Sphenoethmoidectomy: the case for ethmoid marsupialization
Authors: Friedman William H. , Katsantonis George P. , Rosenblum Barry N. , Cooper Margaret H. , Slavin Raymond 
Published: October 2006

AbstractThe authors report 510 sphenoethmoidectomics performed on 255 patients between 1969 and 1985. An overall polyp recurrence rate of 19.2% and less than a 1% complication rate are reported during that time. In patients followed jointly by the otolaryngologists and allergist, including 374 consecutive sphenoethmoidectomies on 187 patients who had this operation performed by the senior author, there was an overall polyp recurrence rate of 15% and a complication rate which was again less than 1%. Recent improvements in recurrence rates and diminished complication rates are attributed to better visualization and adherence to the concept of complete exenteration or marsupialization of the ethmoid labyrinth including middle turbinate resection in every case. Cooperation between the otolaryngologist and allergist is stressed, along with the realization that pulmonary and sinus diseases are frequently interrelated and may both be benefited by the performance of sphenoethmoidectomy in the patient with hyperplastic rhinosinusitis.
The use of gore‐tex®E‐ptfe bonded to silicone rubber as an alloplastic implant material
Authors: Berman Mark , Pearce William J. , Tinnin Monika 
Published: October 2006

AbstractThe purpose of this paper is to evaluate the use of an alloplaslic material, Gore‐TexTM Soft Tissue Patch, which when bonded to silicone rubber (Silastic⊚) may represent a more “ideal” implant material. It's use in the rabbit model is compared to Silastic⊚ alone, Supramid⊚ Mesh, and cartilage control. Grafts were harvested at 3 weeks and 3 months, and the histologic findings were reviewed. Our results demonstrate that the implant is quite inert (minimal tissue reaction), allows for tissue ingrowth with reduced capsule formation, and protects the silicone rubber infrastructure from encapsulation. These findings suggest that Gore‐TexTM Soft Tissue Patch bonded to silicone rubber is a superior implant material and is worthy of consideration for clinical applications.
Regeneration of the eighth cranial nerve. i. anatomic verification in the bullfrog
Authors: Newman Anita , Kuruvilla Alexander , Pereda Alberto , Honrubia Vicente 
Published: October 2006

AbstractThe regenerative capacity of the eighth cranial nerve of the bullfrog, Rana catesbeiana, was investigated. The nerve was sectioned between the ganglion and the brain stem in 16 experimental animals. Horseradish peroxidase was extracellularly injected distal to the site of the nerve section five or more weeks postoperatively. Labeled fibers were identified histologically and their central nervous system projections studied. The findings were as follows: 1. The eighth cranial nerve of the bullfrog regenerated after preganglionic axotomy. 2. Fibers of all sizes regenerated. The regenerated fibers in the nerve were disorderly at the site of nerve section. Most fibers entered the brain stem and formed a vestibuloauditory tract, although some “escaped” and coursed along the brain stem. 3. The regenerated vestibuloauditory tract was situated more laterally than normal, with thick and thin fibers intermixed. 4. Regenerated tertiary fibers were long and tortuous and had unusual trajectories. 5. All vestibuloauditory nuclei received thick and thin afferent fibers.
Predictive value of laboratory tests in “autoimmune” inner ear disease: preliminary report
Authors: Hughes Gordon B. , Kinney Sam E. , Nalepa Nancy L. , Barna Barbara P. , Calabrese Leonard H. 
Published: October 2006

AbstractThe purpose of this prospective, controlled study was to estimate the prevalence of immune‐mediated (autoimmune) inner ear disease in a high‐risk patient population, in order to determine the predictive value of a positive lymphocyte transformation test. The high‐risk group was defined as any dizzy patient with unilateral or bilateral‐asymmetric sensorineural hearing loss, who had not previously received immunotherapy.From more than 400 consecutive patients with a chief complaint of dizziness, 58 were entered into the study over an 8‐month period. The control group consisted of 15 normal volunteers. Thirteen patients (22%) and one control (7%) had positive lymphocyte transformation tests.The data suggest that positive results in “high‐risk” patients are more common than previously believed. Assuming test sensitivity is 96%, specificity 93%, and disease prevalence 22% in high‐risk patients, the predictive value of a positive lymphocyte transformation test using inner ear membranes is 79%. That is, approximately three fourths of all positive results are true positives.Positive results in suspected patients, therefore, should be considered true positives, and treatment recommended. Future research should attempt to refine the putative antigen(s), further define “high risk” patients, and prospectively verify these preliminary results.
Otogenic pneumocephalus
Authors: Andrews James C. , Canalis Rinaldo F. 
Published: October 2006

AbstractFifty‐four previously reported cases of otogenic pneumocephalus were analyzed in addition to five new cases which are presented in detail. Forty‐one males and 18 females were included with 95% of the patients being over 12 years of age. The most common presenting symptom was headache, and the ventricular system was the intracranial space most commonly involved. Tension pneumocephalus was present in 40 (66%) cases. Trauma (36%) was the most common etiologic factor, while otitis media (30%), otologic surgery (30%), and congenital defects (2%) accounted for the rest. The overall mortality was 12% with all patients succumbing to causes other than pneumocephalus. Because of its lack of specific symptoms, pneumocephalus was usually unsuspected and the diagnosis made only after radiographic evaluation. Despite its rarity, pneumocephalus has to be considered whenever the dura is violated, especially if associated with a CSF leak. Management depends on the degree of tension, symptomatology, and underlying cause. When associated with trauma or surgery, bedrest and close monitoring may suffice, although needle aspiration or re‐exploration may be needed. When secondary to otitis media or a congenital defect, control of any infection and repair of the defect are mandatory.
Magnetic resonance imaging and computerized tomography in malignant external otitis
Authors: Gherini Stuart G. , Brackmann Derald E. , Bradley William G. 
Published: October 2006

AbstractIn malignant external otitis (MEO), determining the anatomic extent of disease and evaluating the physiologic response to therapy remain a problem. Magnetic resonance imaging (MRI) has recently become available in limited clinical settings. Four patients with MEO were evaluated using MRI, computerized tomography (CT), technetium‐99 (Tc‐99) bone scanning, and gallium‐67 citrate (Ga‐67 citrate) scanning.MRI is superior to CT, Tc‐99 bone scanning, and Ga‐67 citrate scanning in evaluating the anatomic extent of soft tissue changes in MEO. MRI alone cannot be relied upon to determine the physiologic response to therapy. MRI can, however, serve as a valuable guide to the interpretation of Tc‐99 bone and Ga‐67 citrate scans, and in this respect, MRI is extremely useful in the treatment of MEO.
The shelf life of the university of pennsylvania smell identification test (UPSIT)
Authors: Doty Richard L. , Agrawal Udayan 
Published: October 2006

AbstractThe shelf life of the University of Pennsylvania Smell Identification Test was studied by comparing, using a within‐subjects design, scores for tests manufactured within 2 months of the time of testing, 2½ years before the time of testing, and 4 years before testing. A three‐way analysis of variance (test age by gender by booklet presentation order) revealed no significant effects of test age, presentation order, or any of the interactions on the average test scores. However, a significant gender main effect was observed (the women outperformed the men). The number of persons who correctly identified each test item was examined using the Cochran Q test. A significant difference was found among the three groups for only one of the 40 items (lemon). The percentage of persons who correctly identified lemon was lowest with the 4‐year‐old tests (respective percentages of correct values for the recent, 2½‐year, and 4‐year tests were 100%, 97%, and 67%). It is not clear, however, whether this variation is the result of test age, per se, or vagaries in the manufacturing process. Overall, the data indicate that tests stored in a dry place at room temperature have a long shelf life and can be validly used for assessing patient smell function.
The effect of head and neck radiation therapy on voice quality
Authors: Hoyt David J. , Lettinga James W. , Leopold Kenneth A. , Fisher Samuel R. 
Published: October 2006

AbstractTwenty‐five patients with squamous cell carcinoma of the head and neck who received radiation therapy as their only form of treatment underwent a computer‐assisted voice analysis before, and 6 months following treatment. Those with early laryngeal tumors had a significant improvement in intelligibility (P = .07), percent of sound voiced (P = .04), and sound perturbation. Those with nonlaryngeal tumors had no change in any measured parameters. Head and neck radiation therapy can significantly improve the voice quality of patients with laryngeal tumors, while having a minimal effect on the voice quality of those with nonlaryngeal tumors.
Extracorporeal piezoelectric shock‐wave lithotripsy of salivary gland stones
Authors: Iro Heinrich , Waitz G. , Nitsche N. , Benninger J. , Schneider T. H. , Ell C. H. 
Published: October 2006

AbstractPiezoelectric lithotripsy was undertaken on 19 patients with salivary stones, with none of these patients requiring anesthesia, analgetics, or sedatives. All salivary stones were totally fragmented during first lithotripsy. Four months after treatment with extracorporeal shock waves, all patients were free of symptoms and, in 11 of the patients, no calculi could be found sonographically. The piezoelectric lithotripsy of salivary stones caused no serious side effects which could be proven by clinical, biochemical, sonographic, and magnetic resonance imaging (MRI) examinations.Extracorporeal piezoelectric lithotripsy is a new and promising nonsurgical therapy for selected cases of sialolithiasis of the parotid and submandibular glands.
Vocal cord augmentation with autogenous fat
Authors: Brandenburg James H. , Kirkham Wayne , Koschkee Danna 
Published: October 2006

AbstractSince 1987, the authors have used a new technique for the augmentation and medialization of the paralyzed vocal cord. Eleven patients with paralyzed vocal cords and one patient with a surgical defect of the vocal cord have been treated with intracordal injections of autogenous fat harvested by suction from the abdominal wall.Treatment efficacy was evaluated by both subjective and objective (videostroboscopic) analyses. Patient follow‐up has ranged from 5 to 42 months. All patients showed significant improvement in voice characteristics. Marked reduction in air flow and increased vocal intensity were observed. Correction of glottic insufficiency has been lasting, indicating that the implanted fat cells are viable. At this time, there has been no evidence of loss of vocal cord substance.The natural qualities of autogenous fat appear to make it an excellent alternative to Teflon® or collagen. The fat is readily available, and easily harvested and injected. A larger patient population and longer follow‐up periods will help determine if these initial findings are consistent.
Nasopharyngeal malignancies in children
Authors: Tom Lawrence W. C. , Anderson Gail J. , Womer Richard B. , Wetmore Ralph F. , Handler Steven D. , Potsic William P. , Goldwein Joel W. 
Published: October 2006

AbstractA retrospective analysis identified 29 children with nasopharyngeal malignancies who were evaluated at the Children's Hospital of Philadelphia from 1970 through 1989. Rhabdomyosarcoma (15) and carcinoma (9) were the most common tumor types, and there were distinct differences in the clinical presentations of these two malignancies. Patients with rhabdomyosarcoma were generally younger than those with carcinoma and enjoyed longer survival. Six (67%) of the children with carcinoma were black; all of the patients with rhabdomyosarcoma were white. Patients with carcinoma were also more likely to present with cervical metastases. The presentation, evaluation, and methods of treatment for pediatric nasopharyngeal malignancies are discussed.
Successful in vitro growth of human respiratory epithelium on a tracheal prosthesis
Authors: Chopra Dharam P. , Kern Robert C. , Mathieu Patricia A. , Jacobs John R. 
Published: October 2006

AbstractReconstruction of tracheal defects may be necessary following trauma or oncologic surgery. Defects up to 8 cm can often be repaired using end‐to‐end anastomosis. Use of a tracheal prosthesis for larger defects has been complicated by recurrent stenosis and infection. Recent animal studies, utilizing a Dacron® polyurethane prosthesis suggest that problems with anastomotic stenosis and infection can be controlled. Problems with a central stenosis within the prosthesis persist when used for defects greater than 6 cm.Establishment of a confluent lining of respiratory epithelium is believed to be necessary for successful prosthetic tracheal reconstruction. Using cell culture techniques, we report the first successful seeding and growth of human respiratory epithelium onto a Dacron polyurethane tracheal prosthesis.
Application of an implantable bone conduction hearing device to patients with unilateral sensorineural hearing loss
Authors: Weber Bruce A. , Roush Jackson , Mcelveen John T. 
Published: October 2006

AbstractThis investigation, comprised of five studies, was undertaken to determine if individuals with newly acquired profound unilateral hearing losses would benefit from an implantable bone‐conduction hearing device. The bone conductor was implanted on the side of the deaf ear at the time of translabyrinthine acoustic tumor resection. Two areas greatly affected by unilateral hearing loss, speech recognition in noise and sound localization, were examined. No improvement in aided performance could be documented in either area.
Contribution to the understanding of the etiology of vocal fold cysts: A functional and histologic study
Authors: Milutinović Zoran , Vasiljević Jovan 
Published: October 2006

AbstractThe etiological theories of vocal fold cysts can be divided into two basic groups: those of congenital and acquired cysts. In ongoing practice, the authors had noted that the greater number of cysts appeared at the functionally most active segment of the vocal folds which, on the other hand, has the least number of glands. Also, it had been noted that patients with vocal fold cysts tended to have hyperkinetic patterns of voice production. These observations indicated the possibility of a functional aspect in the etiology of vocal fold cysts, and consideration of such a possibility was the aim of this work. In 37 cases, the exact location of the cyst was established. In addition, the muscular activity of the phonatory apparatus was estimated, patient self‐descriptions with respect to talkativeness were taken into account, and histological evaluations were made. The cysts were most frequently found in the area of the junction of the anterior and middle thirds of the free edge of the vocal fold. Muscular activity during speech and phonation was increased in study patients. Sixty‐five percent of patients had epidermoid cysts and 35% had retention cysts of the vocal fold. According to study results, the functional aspect of cyst genesis has a marked role in the etiology of vocal fold cysts, which points to the great importance of functional care for cyst patients.
Vincristine‐induced recurrent laryngeal nerve paralysis
Authors: Annino Donald J. , Macarthur Carol J. , Friedman Ellen M. 
Published: October 2006

AbstractVincristine‐sulfate‐related vocal cord paralysis has been reported infrequently in the literature. The neurotoxicity of the vinca alkaloids is well‐known; however, the potential for cranial nerve involvement is not widely recognized. Given the complexity of the typical patient receiving such a chemotherapeutic agent, the potential for misdiagnosis is high. Many patients have primary tumors or metastatic lesions in sites that could cause the clinician to overlook this reversible cause of neurologic dysfunction. This study describes the first three reported pediatric cases of vincristine‐induced vocal cord paralysis. Two patients developed increasing stridor secondary to bilateral vocal cord paralysis; the third developed a unilateral vocal cord paralysis. All resolved spontaneously upon withdrawal of the vincristine. Vinca‐alkaloid‐induced vocal cord paralysis is a potentially dangerous but reversible lesion. Otolaryngologists should be aware of the association between these agents and cranial nerve neuropathies.
The microsurgical anatomy of the abducens nerve in its intracranial course
Authors: Umansky Felix , Valarezo Alberto , Elidan Josef 
Published: October 2006

AbstractThe microsurgical anatomy of the abducens nerve through its intracranial course was studied in 20 specimens obtained from 10 cadaver heads fixed in formalin. Another 20 specimens were used to study the pattern of branching of the nerve trunk. The following intracranial segments were studied: subarachnoid or intracisternal, petroclival, and intracavernous. Angulations, neurovascular relationships, and branching patterns of the nerve are described. The long intracranial course of the abducens nerve, its tortuosity, and its tight attachment to the skull base at the level of the petrous apex may influence its vulnerability in some pathological conditions.