bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immediate application of frozen–thawed embryo transfer cycle in month following COVID‐19 recovery does not impair ongoing pregnancy outcome
Authors: Xu Q. , Mao X. , Zhang J. , Wu L. 
Published: March 2024

ABSTRACTObjectiveTo investigate whether immediate frozen–thawed embryo transfer (FET) in the next month following coronavirus disease 2019 (COVID‐19) recovery affects ongoing pregnancy outcome.MethodsThis was a retrospective cohort study carried out at a university‐affiliated reproductive medicine center. The study group (post‐COVID‐19 group) comprised women who were affected by COVID‐19 in December 2022 and immediately underwent FET in January 2023 after recovery, with transferred embryos not exposed to the infection. The control group comprised women treated during the pre‐COVID‐19 period (January 2019). Multivariable logistic regression analysis and a propensity score matching (PSM) approach were used to control for potential confounders and selection bias.ResultsA total of 200 women were included in the post‐COVID‐19 group and 641 women were enrolled in the control group. The rate of ongoing pregnancy was comparable between the study cohorts in both the unadjusted and confounder‐adjusted logistic regression models. Other reproductive outcomes, including the odds of a positive pregnancy test, implantation, clinical pregnancy and early pregnancy loss, were similar between the comparison groups. PSM models further confirmed the lack of significant differences in pregnancy outcome between the post‐COVID‐19 group and the control group.ConclusionsAmong patients affected by COVID‐19 for whom the transferred embryos were generated prior to infection, an immediate FET cycle in the next month after recovery does not seem to compromise ongoing pregnancy outcome. Thus, women who have frozen embryos from preinfection cycles should be counseled and encouraged to undergo FET as soon as possible after COVID‐19 recovery. © 2024 International Society of Ultrasound in Obstetrics and Gynecology.
Chemical constituents of the leaves of Taxus wallichiana (Taxaceae)
Authors: Le Thinh Duc , Le Da Vy Thi , Tran Tu Hoai , Dang Phu Hoang , Le Tho Huu , Nguyen Mai Thanh Thi , Nguyen Nhan Trung 
Published: March 2024

AbstractFrom CHCl3‐soluble extract of the leaves of Taxus wallichiana (Taxaceae), collected in Lam Dong Province, five compounds were isolated and identified as sciadopitysin (1), ginkgetin (2), (S)‐(+)‐rhododenol (3), (+)‐erythro‐N‐benzoyl‐3‐phenylisoserine methyl ester (4), and (−)‐α‐conidendrin (5). Their chemical structures were determined by 1D and 2D NMR spectra and comparison with published data. Except for (−)‐α‐conidendrin, these remaining compounds were first reported of Taxus wallichiana. Among these compounds, ginkgetin (2), and (−)‐α‐conidendrin (5) showed significant α‐glucosidase inhibitory activity with the IC50 values of 98.5, and 172.1 µm, respectively.
Molecular docking and molecular dynamics approach to identify EGFR and HER2 receptors inhibitory effect of compounds in Zanthoxylum simulans Hance
Authors: Mai Tran Hoang , Huong Le Thi , Ha Vu Manh , Thuy Nguyen Thi , Khanh Do Thi Hong , Tung Bui Thanh 
Published: March 2024

AbstractEpidermal growth factor receptor (EGFR) and human epithelium receptor‐2 (HER2) are members of the epidermal growth factor receptor (EGFR/ErbB) family implicated in the development of many types of carcinoma. Zanthoxylum simulans Hance has the effect of inhibiting growth and causing the death of many types of cancer cells. In this study, the molecular docking method and molecular dynamics simulations were used to evaluate the inhibition abilities of EGFR and HER2 receptors of 120 compounds in Zanthoxylum simulans Hance. The results showed two compounds that inhibit both EGFR and HER2 targets including simulanoquinoline and 6‐acetonyldihydroavicine. Therefore, in vivo and in vitro studies of these potential compounds should be carried out to become anti‐cancer drugs in the future.
Improving mechanical properties of huntite hydromagnesite reinforced flame retardant polymer composites with calcite and zeolite minerals
Authors: Yilmaz Atay Gül , Mergen Berfin , Sakan Emre , Yücetürk Buket , Yücetürk Mert 
Published: March 2024

AbstractAlthough inorganic minerals used as flame retardants in firefighting are much safer alternative to halogen‐containing ones, it is seen that while they impart non‐flammability, they impair some mechanical properties of polymer composites. In this study, calcite and zeolite minerals, with well‐known incombustibility properties, were used together with huntite hydromagnesite as auxiliary minerals to obtain better mechanical properties. In this context, a synergistic effect was created by adding zeolite and calcite to polymer composite systems containing huntite hydromagnesite, and flame retardant polypropylene matrix composites were produced using a twin screw extruder. The thermal properties of the produced composites were determined by thermogravimetric analysis (TGA). Tensile test was applied to the samples to determine their mechanical properties. Structural and morphological properties were characterized by scanning electron microscopy (SEM) analysis. It was found that with an additive load of 60% by weight, the modulus of elasticity of pure polypropylene was increased from 1215 to 3362 MPa. In addition, by loading zeolite together with huntite hydromagnesite, the maximum tensile strength increased from 15.6 MPa to 22.9 MPa, resulting in an increase of 46.80%. Consequently, the synergistic effect obtained by using zeolite with huntite hydromagnesite improved the mechanical properties of the composite.
Antioxidant activity and chemical composition of Spirolobium cambodianum Baill.
Authors: Yen Huynh Kim , Tuan Nguyen Trong , Thanh Nguyen Quoc Chau , Tran Truong Thi Tu , Men Tran Thanh 
Published: March 2024

AbstractSpirolobium cambodianum Baill., belonging to Apocynaceae family, was used as a traditional medicine to treat various diseases. This study is the first report on antioxidant activities and chemical composition of S. cambodianum Baill. ethanolic leaf extract. The results showed that ethanolic extract had potent in vitro antioxidant activities in DPPH, ABTS•+ assays (the low concentrations of IC50 were 19.51 ± 0.78 µg/mL and 4.89 ± 0.07 µg/mL, respectively), and in RP, TAC methods (the Abs0.5 were 20.80 ± 0.26 µg/mL and 36.15 ± 1.03 µg/mL). Moreover, investigating in vivo antioxidant activity under oxidative stress conditions caused by paraquat and H2O2 using Drosophila melanogaster showed that flies were raised in the medium supplemented with a concentration of extract (1 mg/mL) lived longer than standard medium. Notably, the chemical investigation of S. cambodianum extract, ten identified compounds were reported for the first time from this plant and from the genus Spirolobium, including 27‐p‐Z‐coumaroyloxyursolic acid (1), lupeol (2), p‐hydroxybenzoic acid (3), ursolic acid (4), tectoquinone (5), daucosterol (6), asiatic acid (7), naringenin (8), 1‐O‐β‐D‐glucopyranosyl‐(2S,3S,4R,9Z)‐2‐[(2′R)‐2′‐hydroxytetracosanoylamino]‐octadec‐9‐en‐1,3,4‐triol (9), quercetin (10). This study suggests that the antioxidant efficacy of S. cambodianum leaf extract and its constituents can be explored as a potential antioxidant agent to treat various diseases, especially oxidative stress.
To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT‐1·DENR to deliver initiator tRNA to ribosomes
Authors: Grove Daisy J. , Russell Paul J. , Kearse Michael G. 
Published: March 2024

AbstractSelection of the correct start codon is critical for high‐fidelity protein synthesis. In eukaryotes, this is typically governed by a multitude of initiation factors (eIFs), including eIF2·GTP that directly delivers the initiator tRNA (Met‐tRNAiMet) to the P site of the ribosome. However, numerous reports, some dating back to the early 1970s, have described other initiation factors having high affinity for the initiator tRNA and the ability of delivering it to the ribosome, which has provided a foundation for further work demonstrating non‐canonical initiation mechanisms using alternative initiation factors. Here we provide a critical analysis of current understanding of eIF2A, eIF2D, and the MCT‐1·DENR dimer, the evidence surrounding their ability to initiate translation, their implications in human disease, and lay out important key questions for the field.This article is categorized under:
RNA Interactions with Proteins and Other Molecules > RNA‐Protein Complexes
Translation > Mechanisms
Translation > Regulation
From “Human versus Machine” to “Human with Machine”
Authors: Simon Gyorgy , Aliferis Constantin 
Published: March 2024

AbstractThis chapter first reviews areas where AI/ML and other automated decision making performs well in hard problems in the health sciences. It also summarizes main results from the literature comparing empirical performance of AI/ML vs humans. The chapter then addresses foundations of human heuristic decision making (and important related biases), and contrasts those with AI/ML biases. Finally the chapter touches upon how hybrid human/machine intelligence can outperform either approach.
Considerations for Specialized Health AI & ML Modelling and Applications: Imaging—Through the Perspective of Dermatology
Authors: Murphree Dennis H. , Choudhary Anirudh , Bhullar Puneet K. , Comfere Nneka I. 
Published: March 2024

AbstractThis chapter focuses on healthcare applications of deep learning in computer vision, specifically in the context of dermatology and dermatopathology.
Approach to concurrent inguinal hernias during laparoscopic appendectomy for early appendicitis
Authors: Dayı Sabriye , Anayurt Meryem , Çınar Fatma , Kırmacı İsmet , Sancar Serpil 
Published: March 2024

Abstract
Purpose
Concurrent inguinal hernia can be a challenge for a pediatric surgeon during a laparoscopic appendectomy in children. We aimed to present our approach to inguinal hernias seen during laparoscopic appendectomy.

Methods
In our pediatric surgery clinic between July 2019 and December 2022, the records of patients aged 0–18 who underwent laparoscopic appendectomy were retrospectively investigated. The clinical findings, surgical procedure, and results of intervened inguinal hernia cases during laparoscopic appendectomy were evaluated.

Results
Between the study dates, 293 laparoscopic appendectomies were performed in our clinic. Patent processus vaginalis was observed in 5 (1.7%) cases. Laparoscopic hernia repair was performed with the Burnia technique in 2 girls. In one case, the omentum was herniated and adhered to the hernia sac seen during laparoscopy. In another case, swelling in the groin occurred during the introduction of air into the abdomen at the beginning of the operation. Patent processus vaginalis seen in 3 asymptomatic cases was not intervened. There were no postoperative complications or recurrences in the two patients who underwent hernia repair.

Conclusion
Hernia repair with the Burnia technique might be safely performed in symptomatic inguinal hernia cases seen during laparoscopic appendectomy for early appendicitis.
Impact of frailty and prefrailty on the mid-term outcomes and rehabilitation course after cardiac surgery
Authors: Honda Tasuku , Murakami Hirohisa , Tanaka Hiroshi , Nomura Yoshikatsu , Sakamoto Toshihito , Yagi Naomi 
Published: March 2024

Abstract
Purpose
This study examined the impact of frailty and prefrailty on mid-term outcomes and rehabilitation courses after cardiac surgery.

Methods
A total of 261 patients (median age: 73 years; 30% female) who underwent elective cardiac surgery were enrolled in this study. The Japanese version of the Cardiovascular Health Study Frailty Index classified 86, 131, and 44 patients into frailty, prefrailty, and robust groups, respectively. We examined the recovery of walking ability, outcomes at discharge, mid-term all-cause mortality, and rehospitalization related to major adverse cardiovascular and cerebrovascular events (MACCE) across the three cohorts.

Results
The 3-year survival rates in the frailty, prefrailty, and robust groups were 87%, 97%, and 100%, respectively (p = 0.003). The free event rates of all-cause mortality and re-hospitalization related to MACCE were 59%, 79%, and 95%, respectively (p < 0.001), with a graded elevation in adjusted morbidity among patients in the prefrailty (hazard ratio [HR], 4.57; 95% confidence interval [CI], 1.08–19.4) and frailty (HR, 9.29; 95% CI 2.21–39.1) groups. Patients with frailty also experienced a delayed recovery of walking ability and a reduced number of patients with frailty were discharged home.

Conclusion
Frailty and prefrailty adversely affect the mid-term prognosis and rehabilitation course after cardiac surgery.
Designing for collaborative learning in immersive virtual reality: a systematic literature review
Authors: Paulsen Lucas , Dau Susanne , Davidsen Jacob 
Published: March 2024

AbstractImmersive learning technologies such as virtual reality have long been deemed as the next generation of digital learning environments. There is a limited number of studies addressing how immersive technologies can be designed, applied, and studied in collaborative learning settings. This paper presents a systematic review of empirical studies reporting on use of immersive virtual reality in collaborative learning within educational and professional learning settings. 11 studies have been grouped and coded in a textual narrative synthesis, outlining the pedagogical concepts behind the learning design, as well as the design of virtual reality environments and the collaborative learning activities in which the technology is employed. The results suggest that collaborative learning in virtual reality can currently be conceptualised as a shared experience in an immersive, virtually mediated space, where there is a shared goal/problem which learners must attend to collaboratively. This conceptualisation implies a need to design technologies, environments, and activities that support participation and social interaction, fostering collaborative learning processes. Based on the outlined conceptualisation, we present a series of recommendations for designing for collaborative learning in immersive virtual reality. The paper concludes that collaborative learning in virtual reality creates a practice- and reflection space, where learning is perceived as engaging, without the risk of interfering with actual practices. Current designs however struggle with usability, realism, and facilitating social interaction. The paper further identifies a need for future research into what happens within virtual reality, rather than only looking at post-virtual reality evaluations.
Estimating the parameters of competitive Langmuir adsorption isotherms from measured responses to rectangular pulse injections exploiting equilibrium theory
Authors: Mutavdžin Ivana , Seidel-Morgenstern Andreas 
Published: March 2024

AbstractKnowledge of adsorption isotherms is essential for the design and optimization of chromatographic separation processes. Since the experimental determination of these thermodynamic functions is a complicated and time consuming task, there is a need to develop methods which are fast and easy to apply. An attractive group of methods is based on neglecting in the analysis of measured dynamic elution profiles all kinetic effects. These methods assume the validity of an isotherm model equation and exploit the possibility to solve analytically the column mass balance equations of the equilibrium model. If just the dispersive part of an elution profile is, the method is known as “elution by characteristic point” (ECP). The ECP method has been applied successfully to analyse column effluent profiles of single component dissolved in a mobile phase. This work extends the ECP method to analyse just the shapes of elution profiles recorded after injecting samples that contain two key components to be separated. The extended ECP method requires recording only one overloaded elution profile for the two-component mixture and offers a fast and efficient way to estimate isotherm model parameters. The method is in particular attractive if there is limited access to the pure components, as for example in cases of enantiomers. The underlying theory is presented and applied for the case that the adsorption equilibria can be described satisfactorily by the classical competitive Langmuir model. Core of the theory are the available analytical equations describing the outlet concentration profiles of the two solutes for the equilibrium controlled case the. Considering a case study, it is shown that the extended ECP method can be applied successfully for columns characterized by 2500 or more theoretical plates. However, the method can be useful also for columns with lower efficiency. It provides then a rough estimation regarding the isotherm courses.
A self-supervised learning model based on variational autoencoder for limited-sample mammogram classification
Authors: Karagoz Meryem Altin , Nalbantoglu O. Ufuk 
Published: March 2024

Abstract
Deep learning models have found extensive application in medical imaging analysis, particularly in mammography classification. However, these models encounter challenges associated with limited annotated mammography public datasets. In recent years, self-supervised learning (SSL) has emerged as a noteworthy solution to addressing data scarcity by leveraging pretext and downstream tasks. Nevertheless, we recognize a notable scarcity of self-supervised learning models designed for the classification task in mammography. In this context, we propose a novel self-supervised learning model for limited-sample mammogram classification. Our proposed SSL model comprises two primary networks. The first is a pretext task network designed to learn discriminative features through mammogram reconstruction using a variational autoencoder (VAE). Subsequently, the downstream network, dedicated to the classification of mammograms, uses the encoded space extracted by the VAE as input through a simple convolutional neural network. The performance of the proposed model is assessed on public INbreast and MIAS datasets. Comparative analyzes are conducted for the proposed model against previous studies for the same classification task and dataset. The proposed SSL model demonstrates high performance with an AUC of 0.94 for density, 0.99 for malignant-nonmalignant classifications on INbreast, 0.97 for benign-malignant, 0.99 for density, and 0.99 for normal-benign-malignant classifications on MIAS. Additionally, the proposed model reduces computational costs with only 228 trainable parameters, 204.95K FLOPs, and a depth of 3 in mammogram classification. Overall, the proposed SSL model exhibits a robust network architecture characterized by repeatability, consistency, generalization ability, and transferability among datasets, providing less computational complexity than previous studies.

Graphical abstract
Utilizing the potential of Saussurea lappa in aquaculture industry: a review on immune enhancement and pollution remediation
Authors: Naiel Mohammed Abd-Elhady , Shehata Abdelrazeq Mohamed , Paswan Vinod Kumar , Said Mourad Ben , El-Tarabily Khaled A. 
Published: March 2024

AbstractAquaculture and the production of aquatic goods are rapidly growing industries in the world. These industries involve the cultivation of various saltwater and freshwater fish as well as shellfish species, and they undergo regular updates in their manufacturing processes. The increasing popularity of aquaculture is driven by the desire to achieve long-term sustainability in food production. However, the intensification of farming techniques can lead to economic losses due to fish mortality, which is often caused by infectious and stressful conditions. To address this challenge, it is crucial to enhance the immune response of fish as part of sustainable intensification and aquaculture management. Recently, there has been growing interest in eco-friendly and natural bioactive solutions as potential alternatives to synthetic compounds used for disease prevention in aquaculture. Medicinal plants, available as whole plants, plant extracts, or synthetic analogues of natural substances known as phytomedicines or phytopharmaceuticals, have shown high efficacy in disease prevention for humans and animals. One such medicinal plant is Saussurea lappa, which is extensively utilized in various forms of medicine for treating multiple diseases. The bioactive chemicals derived from S. lappa exhibit a wide range of biological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer properties, along with immunostimulatory effects. Given the diverse biological activities of S. lappa and its potential to enhance the immune responses of aquatic species, this review focuses on exploring its contributions in this area. By examining the numerous benefits and applications of S. lappa, we aim to shed light on its potential role in improving the immune response of aquatic species.
Comprehensive Analyses of PANoptosome with Potential Implications in Cancer Prognosis and Immunotherapy
Authors: Cai Yonghua , Xiao Heng , Zhou Qixiong , Lin Jie , Liang Xianqiu , Xu Wei , Cao Yongfu , Zhang Xian , Wang Hai 
Published: March 2024

Abstract
Cell death resistance significantly contributes to poor therapeutic outcomes in various cancers. PANoptosis, a unique inflammatory programmed cell death (PCD) pathway activated by specific triggers and regulated by the PANoptosome, possesses key features of apoptosis, pyroptosis, and necroptosis, but these cannot be accounted for by any of the three PCD pathways alone. While existing studies on PANoptosis have predominantly centered on infectious and inflammatory diseases, its role in cancer malignancy has been understudied. In this comprehensive investigation, we conducted pan-cancer analyses of PANoptosome component genes across 33 cancer types. We characterized the genetic, epigenetic, and transcriptomic landscapes, and introduced a PANoptosome-related potential index (PANo-RPI) for evaluating the intrinsic PANoptosome assembly potential in cancers. Our findings unveil PANo-RPI as a prognostic factor in numerous cancers, including KIRC, LGG, and PAAD. Crucially, we established a significant correlation between PANo-RPI and tumor immune responses, as well as the infiltration of diverse lymphoid and myeloid cell subsets across nearly all cancer types. Moreover, a high PANo-RPI was consistently associated with improved immunotherapy response and efficacy, as evidenced by re-analysis of multiple immunotherapy cohorts. In conclusion, our study suggests that targeting PANoptosome components and modulating PANoptosis may hold tremendous therapeutic potential in the context of cancer.