bluuebunny/crossref_metadata_2025_split huggingface dataset:
A “MeerKAT-meets-LOFAR” study of the complex multi-component (mini-)halo in the extreme sloshing cluster Abell 2142
Authors: Riseley C. J. , Bonafede A. , Bruno L. , Botteon A. , Rossetti M. , Biava N. , Bonnassieux E. , Loi F. , Vernstrom T. , Balboni M. 
Published: March 2024

Context. Clusters of galaxies are known to be turbulent environments, whether they are merging systems where turbulence is injected via the conversion of gravitational potential energy into the intracluster medium (ICM), or whether they are relaxed systems in which small-scale core sloshing is occurring within the potential well. In many such systems, diffuse radio sources associated with the ICM are found: radio haloes and mini-haloes.
Aims. Abell 2142 is a rich cluster undergoing an extreme episode of core sloshing, which has given rise to four cold fronts and a complex multi-component radio halo. Recent work revealed that there are three primary components to the halo that spans a distance of up to around 2.4 Mpc. The underlying physics of particle acceleration on these scales is poorly explored, and requires high-quality multi-frequency data with which to perform precision spectral investigation. We aim to perform such an investigation.
Methods. We used new deep MeerKAT L-band (1283 MHz) observations in conjunction with LOFAR HBA (143 MHz) data as well as X-ray data from XMM-Newton and Chandra to study the spectrum of the halo and the connection between the thermal and non-thermal components of the ICM.
Results. We confirm the presence of the third halo component, detecting it for the first time at 1283 MHz and confirming its ultra-steep spectrum nature, as we recovered an integrated spectrum of αH3,  total = −1.68 ± 0.10. All halo components follow power-law spectra with increasingly steep spectra moving towards the cluster outskirts. We profiled the halo in three directions, finding evidence of asymmetry and spectral steepening along an axis perpendicular to the main axis of the cluster. Our investigation of the thermal non-thermal connection shows sub-linear correlations that are steeper at 1283 MHz than 143 MHz, and we find evidence of different connections in different components of the halo. In particular, we find both a moderate anti-correlation (H1, the core) and positive correlation (H2, the ridge) between the radio spectral index and X-ray temperature.
Conclusions. Our results are broadly consistent with an interpretation of turbulent (re-)acceleration following an historic minor cluster merger scenario in which we must invoke some inhomogeneities. However, the anti-correlation between the radio spectral index and X-ray temperature in the cluster core is more challenging to explain; the presence of three cold fronts and a generally lower temperature may provide the foundations of an explanation, but detailed modelling is required to study this further.
Spatially resolving the AGB star V3 in the metal-poor globular cluster 47 Tuc with VLTI/GRAVITY
Authors: Ohnaka K. , Weigelt G. , Hofmann K.-H. , Schertl D. 
Published: March 2024

Context. Mass loss at the asymptotic giant branch (AGB) plays an important role not only in the final fates of stars, but also in the chemical evolution of galaxies. Nevertheless, the metallicity effects on AGB mass loss are not yet fully understood.
Aims. We present spatially resolved observations of an AGB star, V3, in the metal-poor globular cluster 47 Tuc (NGC 104).
Methods. The AGB star 47 Tuc V3 was observed using the GRAVITY instrument at ESO’s Very Large Telescope Interferometer (VLTI) at 2–2.45 μm, with a projected baseline length of up to 96 m.
Results. The object 47 Tuc V3 has been spatially resolved and stands as the first to attempt to spatially resolve an individual star in a globular cluster. The uniform-disk fit to the observed data results in an angular diameter of ∼0.7 mas. Our modeling of the spectral energy distribution and near-infrared interferometric GRAVITY data suggests that the observed data can be explained by an optically thin dust shell with a 0.55 μm optical depth of 0.05–0.25, consisting of metallic iron grains, likely together with effects of the extended atmosphere of the central star. The dust temperature at the inner shell boundary is 500–800 K (corresponding to 23–90 stellar radii), significantly lower than observed in nearby oxygen-rich AGB stars. Radiation pressure on small (< 0.05 μm) iron grains is not sufficient to drive stellar winds. Therefore, iron grains may grow to larger sizes, even in the metal-poor environment. Alternatively, it is possible that the observed iron grain formation is a result of the mass outflow initiated by some other mechanism(s).
Conclusions. The sensitivity and angular resolution of VLTI provides a new window onto spatially resolving individual stars in metal-poor globular clusters. This allows us to improve subsequent studies of the metallicity dependence of dust formation and mass loss.
Hygienestandards im OP – führen sie nachhaltig zur Verbesserung der
Qualität?
Authors: Holz Mathias , Lippross Sebastian , Seekamp Andreas 
Published: March 2024

Zusammenfassung
Hintergrund Nosokomiale Infektionen und postoperative Wundinfektionen sind in
Deutschland eine für das Gesundheitssystem und die betroffenen Patientinnen und Patienten
erhebliche Belastung. Eine postoperative Wundinfektion geht oft mit einer massiven
Verschlechterung der Qualität des Behandlungserfolges chirurgischer Maßnahmen bez. der
Patientenbelastung, der funktionellen Ergebnisse und der Wirtschaftlichkeit einer
Behandlung für den Leistungserbringer einher. Ziel dieses Beitrages ist es, die aktuellen
Hygienevorgaben für das perioperative Setting verständlich darzustellen und für alle am
Operationsablauf Beteiligten zu erläutern.
Methode Erläutert wird zunächst die Bedeutung hygienischer Maßnahmen sowie in
einer kurzen Übersicht die Entwicklung bis hin zu modernen Hygienekonzepten der heutigen
Zeit. Anschließend werden die aktuellen Empfehlungen der KRINKO (Kommission für
Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut): „Prävention
postoperativer Wundinfektionen, Empfehlung der Kommission für Krankenhaushygiene und
Infektionsprävention (KRINKO) beim Robert Koch-Institut“ dargestellt.
Schlussfolgerung Hygienisches Arbeiten ist eine Grundvoraussetzung der Arbeit im
operativen Bereich, denn überzeugende Behandlungsergebnisse mit guten funktionellen
Ergebnissen können in vielen Bereichen (z. B. moderne Endoprothetik) ohne eine suffiziente
Hygiene überhaupt nicht erzielt werden. Die modernen Vorgaben zum hygienischen Arbeiten
sind komplex und betreffen alle Bereiche des Krankenhauses. Nur unter Beachtung aller
Säulen der modernen Hygienekonzepte kann das bestmögliche Maß an Prozessqualität
gewährleistet werden.
Rektumkarzinom: neoadjuvante Strategien und total neoadjuvante Therapie
Authors: Hofheinz Ralf-Dieter 
Published: March 2024

ZusammenfassungDie Behandlungsstrategien beim lokal fortgeschrittenen Rektumkarzinom sind stark im
Wandel. Die in den Leitlinien für lokal fortgeschrittene Tumoren uniform empfohlene Therapie
mit neoadjuvanter Radio(chemo)therapie (RChT), gefolgt von Chirurgie und ggf. adjuvanter
Therapie ist mittlerweile zugunsten folgender Konzepte verlassen: 1. verlängerte neoadjuvante
Therapie („mehr Chemotherapie vor der Operation“ als totale neoadjuvante Therapie, TNT,
bezeichnet); 2. Organerhalt bei Patienten mit einem kompletten klinischen Ansprechen nach
einer neoadjuvanten RChT; 3. Verzicht auf Strahlentherapie bei niedrigem Lokalrezidivrisiko;
4. definitive Immuntherapie mit Checkpoint-Inhibitoren bei Patient*innen mit einem
mikrosatelliteninstabilen (MSI) Primärtumor. Im vorliegenden Beitrag sollen ausgehend vom
leitlinienbasierten Status quo diese 4 neuen Strategien und aktuelle Studienkonzepte
diskutiert werden.
Endoskopische Resektionsverfahren von flächigen Präkanzerosen und Frühkarzinomen im Rektum
Authors: Hochberger Jürgen , Loss Martin , Kruse Elena 
Published: March 2024

ZusammenfassungDie Endoskopie spielt heute nicht nur in der Erkennung von kolorektalen Adenomen und
Karzinomen eine entscheidende Rolle, sondern auch in der Behandlung von insbesondere flächigen
Adenomen und frühen Karzinomen. In den letzten Jahren hat neben der klassischen Polypektomie
und Mukosaresektion flach-erhabener Läsionen mit der Schlinge (EMR), die endoskopische
Submukosadissektion (ESD) einen zunehmenden Stellenwert erlangt. Hierbei erfolgt nach
Markierung, Unterspritzung und Inzision der Mukosa um die Läsion, die Untertunnelung und das
„En-bloc“-Auslösen durch eine transparente Aufsatzkappe und ein feines Diathermiemesser.
Gerade bei flächigen Veränderungen mit hohem Rezidivrisiko einer Piecemeal-Resektion durch EMR
sowie bei Risikoläsionen ermöglicht die ESD, nahezu größenunabhängig in der Hand des
Erfahrenen, einen sicheren Abtrag mit einer histologischen R0-Resektionsrate an Zentren von
weit über 90%. Die ESD ermöglicht eine optimale histopathologische Ausbeute und weist ein
niedriges Rezidivrisiko von 1–3% auf. Eine weitere Bereicherung des Armamentariums stellt die
endoskopische Vollwandresektion mit einem speziellen Applikationssystem dar (FTRD-System).
Dieses eignet sich für umschriebene submuköse, suspekte oder narbige Veränderungen bis 2 cm
Größe im mittleren und oberen Rektum. Die endoskopische intermuskuläre Dissektion (EID)
ermöglicht durch Mitnahme der zirkulären inneren Muskelschicht bei der Resektion die
histopathologische Analyse der kompletten Submukosa über Mukosa und obere Submukosaschicht
hinaus. Sie bietet bei T1-Karzinomen ein geringeres Risiko der basalen R1-Situation und eine
neue Perspektive durch die kurative, organerhaltende endoskopische Therapie bei alleiniger
tiefer Submukosainfiltration ohne weitere Risikofaktoren für eine Metastasierung.
Indikationen, Technik und Stellenwert der verschiedenen Techniken bei prämaligen und
frühmaligen Läsionen im Rektum werden dargestellt.
State of the Art Rektumchirurgie
Authors: Conradi Lena-Christin , Haas Gwendolyn , Fleischer Johannes Robert , Ghadimi Michael 
Published: March 2024

ZusammenfassungDie multimodale Therapie des Rektumkarzinoms hat sich über die letzte Dekade erheblich
differenziert je nach Charakteristika des Tumors und Gegebenheiten des Patienten. Die
Operation stellt weiterhin eine wichtige Säule der Therapie dar, deren Qualität von
prognostischer Relevanz für betroffene Patienten ist. Diese Übersicht gibt einen aktuellen
Überblick zur Indikation der verschiedenen chirurgischen Verfahren, aktuellen Entwicklungen
zum perioperativen Management sowie zum Zeitpunkt einer Operation.
Update zum Sjögren-Syndrom: Diagnostik & Therapie
Authors: Zehrfeld Nadine , Witte Torsten , Ernst Diana 
Published: March 2024

ZusammenfassungMit einer Prävalenz von circa 1:100 bis 1:400 ist das Sjögren-Syndrom die
häufigste Kollagenose und betrifft hauptsächlich Frauen. Bei der Erkrankung
steht die Destruktion der exokrinen Drüsen im Vordergrund und führt so regelhaft
zur Sicca-Symptomatik. In über 50% der Fälle kommt es auch zu extraglandulären
Manifestationen. Insbesondere Fatigue und Arthralgien aber auch verschiedene
systemische Organmanifestationen wie Polyneuropathien oder interstitielle
Lungenerkrankungen können auftreten. PatientInnen mit bestimmten Risikofaktoren
haben eine Wahrscheinlichkeit von fünf Prozent ein Lymphom zu entwickeln. Die
Diagnostik orientiert sich an den aktuellen ACR/EULAR-Klassifikationskriterien,
der Speicheldrüsensonographie, sowie diversen Biomarkern, insbesondere den
Antikörpern gegen SSA/Ro, in Verbindung mit der klinischen Symptomatik. Es gibt
bislang keine zugelassene systemische immunsuppressive Therapie. Die European
League against rheumatism (EULAR) hat Therapieempfehlungen veröffentlicht, die
sich an den Empfehlungen für die Therapie des Systemischen Lupus Erythematodes
orientieren und je nach klinischer Ausprägung und Manifestation variieren.
Verschiedene, durchaus vielversprechende Studien zu unterschiedlichen
therapeutischen Ansätzen werden aktuell durchgeführt.
Two-Year Functional Outcomes of Nonsurgical Treatment in Concomitant Anterior Cruciate Ligament and Medial Collateral Ligament Injuries: A Case-Control Study
Authors: Dadgostar Heleh , Zarrini Mojgan , Hoveidaei Amir Human , Sattarpour Reza , Razi Saeed , Arasteh Peyman , Razi Mohammad 
Published: March 2024

AbstractThe anterior cruciate ligament (ACL) is a common knee injury in high-intensity sports, which can cause early career loss in young athletes. Concomitant damage to other knee stabilizers may occur, such as the medial collateral ligament (MCL). Recent studies have shown that knee stability can increase without surgical intervention in patients with ACL and MCL injuries. Regarding the importance of functional tests in return to exercise prediction, this study aims to measure nonsurgical approach's long-term outcome for concomitant ACL and MCL injuries with a focus on functional tests. This is a case-control study with a 2-year follow-up. The case group consisted of patients who had provided written consent and completed their 2-year follow-up, and the control group was made up of healthy people who did not have any knee medical conditions and were matched by age, gender, and activity level. Physical examinations, Tegner and International Knee Documentation Committee questionnaires, and knee magnetic resonance imaging were conducted, and functional performance tests were performed after a 10-minute warm-up. Lody's index (the ratio of injured-to-uninjured knee results) was calculated. The data were analyzed using independent t-test, one-way analysis of variance, chi-squared test, and Fisher's exact test. The study involved 11 patients in each concomitant ACL and MCL injury cases and healthy control groups with a mean age of 32.4 and 28 years, respectively. None of the patients reported knee instability symptoms in the 2-year follow-up. More than half of the patients continued their sports field without reinjury, with no significant difference in activity levels between case and control groups. The 6-meter hop test and single-leg hop test showed no significant difference between case and control groups (p-value: 0.326, 0.859), and no significant difference was observed in the three Carioca, cocontraction, and Shuttle tests in the 2-year follow-up. Functional tests in ACL and MCL injuries revealed normal outcomes, implying a nonsurgical approach for patients with proximal ACL tears, better knee stability, and no significant differences between the injured and control groups.
PDE10A Mutation as an Emerging Cause of Childhood-Onset Hyperkinetic Movement Disorders: A Review of All Published Cases
Authors: Kalampokini Stefania , Xiromerisiou Georgia , Bargiotas Panagiotis , Anastasiadou Violetta Christophidou , Costeas Paul , Hadjigeorgiou Georgios M. 
Published: March 2024

AbstractCyclic nucleotide phosphodiesterase (PDE) enzymes catalyze the breakdown of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), which act as intracellular second messengers for signal transduction pathways and modulate various processes in the central nervous system. Recent discoveries that mutations in genes encoding different PDEs, including PDE10A, are responsible for rare forms of chorea in children led to the recognition of an emerging role of PDEs in the field of pediatric movement disorders. A comprehensive literature review of all reported cases of PDE10A mutations in PubMed and Web of Science was performed in English. We included eight studies, describing 31 patients harboring a PDE10A mutation and exhibiting a hyperkinetic movement disorder with onset in infancy or childhood. Mutations in both GAF-A, GAF-B regulatory domains and outside the GAF domains of the PDE10A gene have been reported to cause hyperkinetic movement disorders. In general, patients with homozygous mutations in either GAF-A domain of PDE10A present with a more severe phenotype and at an earlier age but without any extensive abnormalities of the striata compared with patients with dominant variants in GAF-B domain, indicating that dominant and recessive mutations have different pathogenic mechanisms. PDE10A plays a key role in regulating control of striato-cortical movement. Comprehension of the molecular mechanisms within the cAMP and cGMP signaling systems caused by PDE10A mutations may inform novel therapeutic strategies that could alleviate symptoms in young patients affected by these rare movement disorders.
Early Clinical and Radiologic Evaluation of Unilateral Biportal Endoscopic Unilateral Laminotomy and Bilateral Decompression in Degenerative Lumbar Spinal Stenosis: A Retrospective Study
Authors: Yin Jianjian , Ma Tao , Gao Gongming , Chen Qi , Nong Luming 
Published: March 2024

Abstract
Background The aim of this study is to evaluate the changes in radiologic parameters and clinical outcomes following unilateral biportal endoscopic unilateral laminotomy and bilateral decompression (UBE ULBD) for treatment of central lumbar spinal stenosis.
Methods Forty-one central lumbar spinal stenosis patients who underwent UBE ULBD were enrolled from April 2021 to February 2023. Visual analog scale (VAS) for back pain and leg pain, Oswestry Disability Index (ODI) score, and the modified MacNab criteria were assessed preoperatively and postoperatively. The preoperative and postoperative cross-sectional area of the spinal canal (CSAC), anteroposterior diameter, horizontal width, and ipsilateral and contralateral lateral recess height were calculated from axial computed tomography (CT) scans. Percentage of facet joint preservation measured on axial CT scans was obtained preoperation and postoperation.
Results The VAS for back and leg pain improved from 7.24 ± 0.80 and 7.59 ± 0.59 preoperatively to 2.41 ± 0.55 and 2.37 ± 0.62 (p < 0.05) postoperatively and 1.37 ± 0.54 and 1.51 ± 0.55 at the last follow-up (p < 0.05). For ODI, improvement from 60.37 ± 4.44 preoperatively to 18.90 ± 4.66 (p < 0.05) at the last follow-up was observed. CT scans demonstrated that the postoperative CSAC increased significantly from 287.84 ± 87.81 to 232.97 ± 88.42 mm (p < 0.05). The mean postoperative anteroposterior diameter and horizontal width increased significantly from 18.01 ± 3.13 and 19.57 ± 3.80 to 22.19 ± 4.56 and 21.04 ± 3.72 mm, respectively (p < 0.05). The ipsilateral lateral recess height and contralateral lateral recess height were 3.39 ± 1.12 and 3.20 ± 1.14 mm preoperatively and 4.03 ± 1.37 and 3.83 ± 1.32 mm (p < 0.05) postoperatively, with significant differences. The ipsilateral and contralateral facet joint preservations were 88.17 and 93.18%, respectively.
Conclusion The UBE ULBD surgery is a safe and effective treatment for central lumbar spinal stenosis, associated with significant improvement in clinical outcomes and radiologic parameters. Studies with larger samples and longer follow-up periods are needed for further research.
Marjolin's Ulcer (A Study of 40 Cases)
Authors: Tripathi F. M. , Khanna Mrs. S. , Khanna N. N. , Sinha J. K. , Bhattacharya V. , Bariar L. M. 
Published: March 2024

SummaryPresent series is based on 40 cases of histologically proved Marjolin's ulcer, attending Plastic Surgery Service of University Hospital B. H. U. over a period of 8 years. This tumour is fairly common in this part of India. Adolescents and adult males are commonly affected by this disease. Limbs, especially around joints are the commonest site of involvement. Marjolin's ulcer is rather slow growing malignant tumour mostly over unstable scar of burns, which is not primarily grafted. The lag period in present series is 17 years and lymph node metastasis is less common and distant metastasis is rare. Squamous cell carcinoma is the commonest histologic type and majority of patients have been treated by surgery.Celsus in the first century A.D. was the first man to describe malignant degeneration in a burn scar, however, the term Marjolin's ulcer was given to the carcinoma arising in post traumatic scar which was described for the first time by Jean-Nicholas Marjolin in the year 1828. Since then the term Marjolin's ulcer has been used for the malignant degeneration in chronic ulcers of the skin, sinuses as well as burn scars. Though the lesion described by Marjolin was not thought to be malignant by Marjolin himself, it was identified as malignant by Smith in 1850 and Da Costa (1903) used the term ‘Marjolin's ulcer’ for all such malignant lesions.
Muscle Transposition in Exposed Tibia
Authors: Gill S. S. , Bahadur Raj , Nagi O. N. 
Published: March 2024

SummaryMuscle Transposition along with immediate or delayed fresh split skin grafting has been contemplated in fifteen cases of open fractures of the leg bones where the tibia was exposed. The resuits of this procedure are satisfactory and are usually better in those cases where muscle transposition and skin grafting were done at the first stage. Minor complications like partial necrosis of the skin graft and muscle atrophy has been observed in few cases.
A Method of Managing Electrical Injury Around Oral Cavity
Authors: Bhattacharya V. , Sinha J. K. , Tripathi F. M. 
Published: March 2024

SummaryThis case report illustrates one of the methods for the management of deformities caused by electrical contact around mouth. The lip was advanzad for the reconstruction of oral sphincter. The chin defect was covered by a cervical transposition cum rotation flap.
Management of Postburn Contracture Neck Using Pectoralis Major Myocutaneous Flap
Authors: Bhattacharya Dr. V. , Sinha Dr. J. K. , Tripathi Dr. F. M. , Das Dr. J. M. 
Published: March 2024

SummaryThe use of pectoralis major myocutaneous flap for the management of post-burn contracture of neck is described. Its merits and demerits are discussed.
Laser Treatment of Cutaneous Vascular Anomalies and Pigmented Lesions
Authors: Mishra Mithilesh J. , Alani Hashim 
Published: March 2024

SummaryA total of 232 patients with portwine stains and totoos were examined from 1978 to 1982. One-hundren-seventeen patients were subjected to the test dose of laser to evaluate the initial result and applicability for further treatment. Twenty-five patients were discarded for treatment. A total of 92 patients, 48 patients with hemangiomas, 32 with tattoos, 10 with nevi and 2 patients with multiple warts, were treated with excellent results.
Blood Groups in Carcinomas of the Oral Cavity
Authors: Gupta Y. N. , Gupta Saroj , Gupta O. P. , Khanna N. N. 
Published: March 2024

SummaryDistribution of ABO blood groups, their relative frequencies and statistical significance in relation to controls had been done in 172 patients of carcinomas of the oral cavity. In general oral malignancies were found to be statistically significantly high in blood group B (P <0.001), while considering the individual sites, the predilaction was also found significant in carcinemas of tongue and alveolus.
Reconstruction Of The Thumb (Study of 100 Cases)
Authors: Shah Dr. Ashok C. , Mahaluxmivala Dr. S. M. 
Published: March 2024

SummaryWe have evaluated 100 cases with particular emphasis on tip losses and total thumb loss. Various methods and follow up of partial thumb reconstruction and total thumb reconstruction are discussed.If necessary patients arve referred to physiotherapy and occupational therapy.We are thankful to Dr. B. R. Kalke, Dean. T. N. Medical College and B. Y. L. Nair Hospital, Bombay for his kind pernrission to use the hospital records and publish this paper.