bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preliminary analysis of stimulation parameters for sacral neuromodulation in different indications: a multicenter retrospective cohort study from China
Authors: Meng Lingfeng , Yan Zehao , Wang Xinhao , Zhang Yaoguang , Zhu Zhikai , Zhu Wen , Ling Qing , Sun Xiaoke , Gu Yinjun , Lv Jianwei , Li Yan 
Published: March 2024

Background:
Sacral neuromodulation (SNM) is an effective approach for treating lower urinary tract dysfunction (LUTD), and stimulation programming is essential for successful treatment. However, research on SNM programming for various indications is limited. Thus, the authors aimed to determine whether there were differences in the stimulation parameters for different SNM indications and the appropriate programming recommendations.

Materials and methods:
Clinical data were retrospectively collected from patients with LUTD who underwent SNM and completed internal pulse generator implantation. The parameters with the highest patient satisfaction or the most symptom improvement during the test period were considered optimal and used to set the programming after internal pulse generator implantation.

Results:
After screening, 282 patients were enrolled and categorized into four groups based on the following indications: refractory overactive bladder (OAB) (n=61), neurogenic lower urinary tract dysfunction (nLUTD) (n=162), interstitial cystitis/painful bladder syndrome (IC/BPS) (n=24), and idiopathic nonobstructive urinary retention (NOUR) (n=35). When analyzing the optimal stimulus parameters, disparities in the stimulation amplitude and pulse frequency were noted among the four groups. The stimulation amplitude in the nLUTD group was higher than that in the idiopathic NOUR group (P=0.013). Differences in pulse frequency were observed between the refractory OAB and nLUTD groups (P<0.001) and between the refractory OAB and idiopathic NOUR groups (P=0.001). No differences in the electrode configuration or pulse width settings existed among the four groups.

Conclusions:
The stimulation parameters for SNM varied among the different indications. For the initial programming of stage I, most patients are recommended to start with stimulation amplitudes below 2 V, although patients with nLUTD may benefit from higher amplitudes. A standard pulse width of 210 μs is recommended for all patients. However, for individuals experiencing nLUTD or idiopathic NOUR, the pulse frequency can begin above the standard 14 Hz but not exceed 50 Hz.
Malignant hyperthermia in a paediatric patient; managed successfully without dantrolene: a case report
Authors: Ranjit Sangina , Kharbuja Kalpana , Shrestha Ashish , Timalsina Binod , Ranjitkar Neeti , Chaudhary Ashlesha 
Published: March 2024

Introduction:
Malignant hyperthermia (MH) is a potentially life-threatening pharmacogenetic syndrome triggered by volatile anaesthetics, succinylcholine, and stress such as vigorous exercise.

Case presentation:
The authors describe a case of an 8-year-old male who presented with classical symptoms of MH after induction of general anaesthesia and symptomatic treatment was done successfully due to the unavailability of Dantrolene.

Discussion:
Definitive diagnosis of MH can be done based on a contracture test in fresh muscle biopsy in the presence of halothane and caffeine. In the absence of muscle biopsy and genetic testing, diagnosis for MH can be done based on MH scoring.

Conclusion:
Anesthesiologists should be made aware that proper symptomatic management can also save the life of a patient. Also, strong advocacy should be done to ensure the availability of Dantrolene and further strengthen lab facilities to confirm diagnosis to facilitate diagnosis and management in the future.
Impact of Hemoglobin Level in Ex Vivo Heart Perfusion on Donation After Circulatory Death Hearts: A Juvenile Porcine Experimental Model
Authors: Kobayashi Yasuyuki , Li Jing , Parker Marlee , Wang Jian , Nagy Anita , Fan Chun-Po Steve , Runeckles Kyle , Okumura Michiru , Kadowaki Sachiko , Honjo Osami 
Published: March 2024

Background.
Ex vivo heart perfusion (EVHP) of donation after circulatory death (DCD) hearts has become an effective strategy in adults; however, the small circulating volume in pediatrics poses the challenge of a low-hemoglobin (Hb) perfusate. We aimed to determine the impact of perfusate Hb levels during EVHP on DCD hearts using a juvenile porcine model.

Methods.
Sixteen DCD piglet hearts (11–14 kg) were reperfused for 4 h in unloaded mode followed by working mode. Metabolism, cardiac function, and cell damage were compared between the low-Hb (Hb, 5.0–5.9 g/dL; n = 8) and control (Hb, 7.5–8.4 g/dL; n = 8) groups. Between-group differences were evaluated using 2-sample t-tests or Fisher’s Exact tests.

Results.
During unloaded mode, the low-Hb group showed lower myocardial oxygen consumption (P < 0.001), a higher arterial lactate level (P = 0.001), and worse systolic ventricular function (P < 0.001). During working mode, the low-Hb group had a lower cardiac output (mean, 71% versus 106% of normal cardiac output, P = 0.010) and a higher arterial lactate level (P = 0.031). Adjusted cardiac troponin-I (P = 0.112) did not differ between the groups. Morphological myocyte injury in the left ventricle was more severe in the low-Hb group (P = 0.028).

Conclusions.
Low-Hb perfusate with inadequate oxygen delivery induced anaerobic metabolism, resulting in suboptimal DCD heart recovery and declined cardiac function. Arranging an optimal perfusate is crucial to organ protection, and further endeavors to refine the priming volume of EVHP or the transfusion strategy are required.
Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma
Authors: Curry Rachel N. , Ma Qianqian , McDonald Malcolm F. , Ko Yeunjung , Srivastava Snigdha , Chin Pey-Shyuan , He Peihao , Lozzi Brittney , Athukuri Prazwal , Jing Junzhan , Wang Su , Harmanci Arif O. , Arenkiel Benjamin , Jiang Xiaolong , Deneen Benjamin , Rao Ganesh , Harmanci Akdes Serin 
Published: March 2024

AbstractPrior studies have described the complex interplay that exists between glioma cells and neurons, however, the electrophysiological properties endogenous to tumor cells remain obscure. To address this, we employed Patch-sequencing on human glioma specimens and found that one third of patched cells inIDHmutant (IDHmut) tumors demonstrate properties of both neurons and glia by firing single, short action potentials. To define these hybrid cells (HCs) and discern if they are tumor in origin, we developed a computational tool, Single Cell Rule Association Mining (SCRAM), to annotate each cell individually. SCRAM revealed that HCs represent tumor and non-tumor cells that feature GABAergic neuron and oligodendrocyte precursor cell signatures. These studies are the first to characterize the combined electrophysiological and molecular properties of human glioma cells and describe a new cell type in human glioma with unique electrophysiological and transcriptomic properties that are likely also present in the non-tumor mammalian brain.
Did Merkel's 2015 decision attract more migration to Germany?
Authors: TJADEN JASPER , HEIDLAND TOBIAS 
Published: March 2024

AbstractIn 2015, German Chancellor Angela Merkel decided to allow over a million asylum seekers to cross the border into Germany. One key concern was that her decision would signal an open‐door policy to aspiring migrants worldwide – thus further increasing migration to Germany and making the country permanently more attractive to irregular and humanitarian migrants. This ‘pull‐effect’ hypothesis has been a mainstay of policy discussions ever since. With the continued global rise in forced displacement, not appearing welcoming to migrants has become a guiding principle for the asylum policy of many large receiving countries. In this article, we exploit the unique case study that Merkel's 2015 decision provides for answering the fundamental question of whether welcoming migration policies have sustained effects on migration towards destination countries. We analyze an extensive range of data on migration inflows, migration aspirations and online search interest between 2000 and 2020. The results reject the ‘pull effect’ hypothesis while reaffirming states’ capacity to adapt to changing contexts and regulate migration.
White American transgender adults' retrospective reports on the social and contextual aspects of their gender identity development
Authors: Herry Emily , Rodan S. M. , Martin Madeline , Sanjak Mariam M. , Mulvey Kelly Lynn 
Published: March 2024

AbstractA growing body of research has attended to the experiences of transgender and gender non‐conforming (TGN) youth's gender identity development. However, practical and ethical concerns have impeded our ability to understand the experiences of TGN youth. Thus, the aim of this study was to utilize one‐on‐one semi‐structured interviews to explore White American TGN adults' (N = 15) retrospective accounts of their gender identity development in childhood and adolescence. Findings demonstrate considerable heterogeneity in TGN adults' retrospective accounts of their gender identity development. However, TGN adults consistently highlighted the role of social (e.g. friends, family and teachers) and contextual (e.g. online, offline, educational and geographical) factors in their gender identity journeys. This study provides new insight into the role of social and contextual factors in TGN adults' retrospective accounts of their gender identity development, demonstrating the importance of continuing to examine these factors in gender diversity research.
Spitz melanocytic neoplasms with MLPH::ALK fusions: Report of two cases with previously unreported features and literature review
Authors: Salah Haneen T. , Yang Richard K. , Roy‐Chowdhuri Sinchita , Ross Merrick I. , Aung Phyu P. , Rothrock Aimi T. , Torres‐Cabala Carlos A. , Curry Jonathan L. , Prieto Victor G. , Nagarajan Priyadharsini , Cho Woo Cheal 
Published: March 2024

AbstractALK‐fused Spitz melanocytic neoplasms are a distinct subgroup of melanocytic lesions exhibiting unique histopathologic characteristics. These lesions often manifest as exophytic or polypoid tumors, characterized by fusiform‐to‐epithelioid melanocytes arranged in a nested, fascicular, or plexiform growth pattern. Several fusion partners of the ALK gene have been identified in spitzoid melanocytic neoplasms, with TPM3 and DCTN1 being the most prevalent. Less common fusion partners include NPM1, TPR, CLIP1, GTF3C2, EEF2, MYO5A, KANK1, and EHBP1. The MLPH gene, which encodes melanophilin (MLPH), playing a crucial role in regulating skin pigmentation by acting as a linker between RAB27A and myosin Va during melanosome transport, has also recently been recognized as a rare fusion partner of ALK in Spitz melanocytic neoplasms. Currently, there exists a sparse documentation within English literature, illustrating a limited number of cases featuring MLPH::ALK fusion in Spitz melanocytic neoplasms. In this report, we present two additional cases, including a previously unreported instance of Spitz melanoma, contributing to the expanding knowledge on ALK‐fused Spitz melanocytic neoplasms. In addition, we provide a comprehensive review of the clinical, histopathologic, and molecular features observed in documented cases with this novel fusion.
Temporal dynamics of invertebrate community assembly in Lake Victoria since the late Pleistocene based on chitinous remains
Authors: King Leighton , Courtney‐Mustaphi Colin , Cuenca‐Cambronero Maria , Wienhues Giulia , Ngoepe Nare , Muschick Moritz , Temoltzin‐Loranca Yunuen , Vogel Hendrik , Grosjean Martin , Tinner Willy , Cohen Andrew , Kishe Mary , Heiri Oliver , Seehausen Ole , Matthews Blake 
Published: March 2024

Abstract

Preserved assemblages of invertebrate remains in lacustrine sediment reveal temporal variations of community composition and environmental conditions. However, records for large tropical lakes are scarce. Lake Victoria, the largest tropical lake, has a dynamic history of changes in water level, biogeochemistry and fish community composition over the past ~17,000 cal yr BP.

In order to quantify changes in the invertebrate assemblage of Lake Victoria from the late Pleistocene throughout the Holocene, we examined chitinous remains of Cladocera and larval dipterans (Chironomidae and Chaoboridae) from a sediment core (37 m water depth) dated from ~13,700 cal yr BP to present.

We identified four major phases in the invertebrate assemblage throughout this period of lake history. Firstly, Chironomidae and Chaoboridae appeared at low abundances during the earliest stages of lake inundation in the late Pleistocene, at a time when Cladocera were notably absent. Secondly, chaoborids and chironomids increased in abundance during the mid‐Holocene, which coincided with high diatom production toward the end of the Holocene African Humid Period. Thirdly, starting ~4,700 cal yr BP, Alona, a predominantly littoral cladoceran genus, consistently appeared in the invertebrate assemblage alongside changes in mixing regimes and persisted throughout the late Holocene to the present. Fourthly, the arrival of both Chydorus and Bosmina longirostris marked the establishment of an abundant cladoceran assemblage at ~1,350 cal yr BP. The assemblage then gradually shifted toward the increasing dominance of B. longirostris, a planktonic cladoceran.

Several of the observed changes in the invertebrate assemblage occurred concurrently with changes in climatic conditions in East Africa and diatom productivity that have been previously recorded in Lake Victoria. This multi‐millennial record of sedimentary invertebrate assemblages in Lake Victoria elucidates some of the temporal development of these communities throughout most of the dynamic modern history of the ecosystem.
Support and employment preferences in online platform work: A cluster analysis of German‐speaking workers
Authors: Klaus Dominik , Lamura Maddalena , Bilger Marcel , Haas Barbara 
Published: March 2024

AbstractOnline platform work is an emerging field of non‐standard employment. Up to now, there has been little knowledge of the perspective of online platform workers on social protection and regulation. We provide quantitative data (n = 1727) on their needs for support and on their employment status preferences. Given the heterogeneity of German‐speaking online platform workers, we have conducted a cluster analysis to group workers according to task length, hourly wage, working hours and experience on online platforms. Most of the respondents are solo‐self‐employed and hybrid workers. They prefer support instruments that improve their skills and income over those that aim to strengthen their rights. The majority of platform workers are in favour of working outside of platforms. The study also shows that despite the low dependence on platform income, the actual poverty risk is relatively high.
Generosity of old‐age pensions for the self‐employed—A typology of European welfare states
Authors: Höppner Julia 
Published: March 2024

AbstractResearch on pension generosity has so far used employees in standard employment as the reference point, ignoring nonstandard forms of employment such as the self‐employed. Moreover, as one of the major concepts of welfare state analysis, generosity has not been considered in research on the old‐age security of the self‐employed. Hence, there is a ‘missing link’ between the two strands in the literature. This paper aims to close this research gap by analysing the differences between 12 European welfare states regarding the generosity of old‐age pensions for the self‐employed. Based on the degree of strictness of access and benefit level, a typology is developed that results in four types of generosity: high generosity, low generosity, basic security and selective generosity.
RETRACTED: Effect of Chinese herbal compound dressings in treating patients with diabetic foot ulcers: A meta‐analysis
Authors: Yang Qian , Liu Fei , Zhao Changxiu , Xu Xin , Wang Yaqi , Zuo Weiwei 
Published: March 2024

AbstractThis meta‐analysis aims to systematically investigate the clinical efficacy of Chinese herbal compound dressings in treating patients with diabetic foot ulcers (DFUs). A comprehensive computerised search was conducted in databases including PubMed, Embase, Google Scholar, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases, from database inception to November 2023, to identify randomised controlled trials (RCTs) concerning the use of Chinese herbal compound dressings in patients with DFU. Two researchers independently screened the literature, extracted data, and assessed the quality based on inclusion and exclusion criteria. Data analysis was performed using Stata 17.0 software. Overall, 18 RCTs involving 1405 DFU patients were included. The analysis indicated that compared to the control group, the group treated with Chinese herbal compound dressings had significantly shorter ulcer healing time (standardised mean difference [SMD] = −2.49, 95% confidence interval [CI]: −3.53 to −1.46, p < 0.001), reduced ulcer surface area (SMD = −3.38, 95% CI: −4.67 to −2.09, p < 0.001), and higher healing rates (odds ratio [OR] = 2.24, 95% CI: 1.72–2.92, p < 0.001) as well as overall effectiveness rates (OR = 4.56, 95% CI: 3.10–6.71, p < 0.001). This study demonstrates that the external application of Chinese herbal compound dressings in patients with DFU can significantly shorten the ulcer healing time and improve wound healing rates.
Effects of evidence‐based nursing care interventions on wound pain and wound complications following surgery for finger tendon injury
Authors: Zhang Xin‐Lan , Wang Chun‐Yan , Pan Liu‐Liu , Li Yu‐Jie 
Published: March 2024

AbstractWe conducted this study aimed to examine the impact of evidence‐based nursing interventions on postoperative wound pain and complications after surgery for finger tendon injury. A total of 86 patients treated for finger tendon injuries at our hospital from January 2021 to October 2023 were selected and randomly divided into an experimental group and a control group. The control group received conventional nursing care, while the experimental group received evidence‐based nursing interventions. The study compared the postoperative wound pain intensity, incidence of complications and patient satisfaction with nursing care between the two groups. The analysis revealed that compared with conventional care, evidence‐based nursing interventions significantly reduced the level of wound pain (p = 0.034) and the incidence of complications (4.65% vs. 18.60%, p = 0.043). It also increased patient satisfaction with the nursing care (97.67% vs. 83.72%, p = 0.026). The study indicates that the application of evidence‐based nursing interventions for patients with finger tendon injuries can reduce postoperative wound pain, decrease the incidence of complications and enhance patient satisfaction with nursing care.
Construction of a nursing assessment framework for patients in anaesthesia recovery period: A modified Delphi study
Authors: Peng Lang , Zang Xianxian , Liu Ruili , Bai Ping , Wang Lu , Yang Guoyong 
Published: March 2024

AbstractAimTo construct a nursing assessment framework for patients in anaesthesia recovery period.DesignA three‐round modified Delphi method was employed to capture the consensus of 22 panellists.MethodsThe initial items in the nursing assessment framework for patients in anaesthesia recovery period were developed based on the mini‐clinical evaluation exercise (mini‐CEX). A panel of 22 experts participated in this study. The panellists have more than 10 years of experience in either clinical anaesthesia, or post‐anesthesia nursing, or operating room nursing, or surgical intensive nursing. Between March and April 2023, the panellists evaluated and recommended revisions to the initial framework.ResultsThis study resulted in the development of a nursing assessment framework for patients in anaesthesia recovery period. The initial version of the framework consisted of six dimensions with 27 items. Six items were modified after the first round of consultation. After the second round, five modifications and four deletions were made based on expert opinion. The third round resulted in a convergence of expert opinion. The framework, which consists of 24 items across five dimensions, was refined. The five dimensions are as follows: History‐taking, Physical assessment, Clinical judgement, Organizational efficiency and Humanistic concern.ConclusionThe nursing assessment framework for patients in anaesthesia recovery period was reached consensus between the 22 experts’ opinions.Implications for the profession and patient careThe assessment framework constructed in this study could be used for the process evaluation of post‐anesthesia nursing. The framework may guide perianesthesia nurses in the timely and effective assessment of patients during this critical phase of care. It may be used for perianesthesia nursing education or to evaluate nurses' assessment skills.Reporting methodThe study is reported in accordance with the Guidance on Conducting and Reporting DElphi Studies (CREDES) recommendations.Patient or public contributionNo patient or public contribution.
Inhibition of UBA52 induces autophagy via EMC6 to suppress hepatocellular carcinoma tumorigenesis and progression
Authors: Tong Li , Zheng Xiaofei , Wang Tianqi , Gu Wang , Shen Tingting , Yuan Wenkang , Wang Siyu , Xing Songlin , Liu Xiaoying , Zhang Chong , Zhang Chao 
Published: March 2024

AbstractUbiquitin A‐52 residue ribosomal protein fusion product 1 (UBA52) has a role in the occurrence and development of tumours. However, the mechanism by which UBA52 regulates hepatocellular carcinoma (HCC) tumorigenesis and progression remains poorly understood. By using the Cell Counting Kit (CCK‐8), colony formation, wound healing and Transwell assays, we assessed the effects of UBA52 knockdown and overexpression on the proliferation and migration of HCC cells in vitro. By establishing subcutaneous and metastatic tumour models in nude mice, we evaluated the effects of UBA52 on HCC cell proliferation and migration in vivo. Through bioinformatic analysis of data from the Gene Expression Profiling Interactive Analysis (GEPIA) and The Cancer Genome Atlas (TCGA) databases, we discovered that UBA52 is associated with autophagy. In addition, we discovered that HCC tissues with high UBA52 expression had a poor prognosis in patients. Moreover, knockdown of UBA52 reduced HCC cell growth and metastasis both in vitro and in vivo. Mechanistically, knockdown of UBA52 induced autophagy through EMC6 in HCC cells. These findings suggest that UBA52 promoted the proliferation and migration of HCC cells through autophagy regulation via EMC6 and imply that UBA52 may be a viable novel treatment target for HCC patients.