bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benchmarking the Intrinsic Activity of Transition Metal Oxides for the Oxygen Evolution Reaction with Advanced Nanoelectrodes
Authors: Gao Han , Xu Jianan , Zhang Xueqi , Zhou Min 
Published: April 2024

AbstractThe intrinsic activity assessment of transition metal oxides (TMOs) as key electrocatalysts for the oxygen evolution reaction (OER) has not been standardized due to uncertainties regarding their structure and composition, difficulties in accurately measuring their electrochemically active surface area (ECSA), and deficiencies in mass‐transfer (MT) rates in conventional measurements. To address these issues, we utilized an electrodeposition‐thermal annealing method to precisely synthesize single‐particle TMOs with well‐defined structure and composition. Concurrently, we engineered low roughness, spherical surfaces for individual particles, enabling precise measurement of their ECSA. Furthermore, by constructing a conductor‐core semiconductor‐shell structure, we evaluated the inherent OER activity of perovskite‐type semiconductor materials, broadening the scope beyond just conductive TMOs. Finally, using single‐particle nanoelectrode technique, we systematically measured individual TMO particles of various sizes for OER, overcoming MT limitations seen in conventional approaches. These improvements have led us to propose a precise and reliable approach to evaluating the intrinsic activity of TMOs, not only validating the accuracy of theoretical calculations but also revealing a strong correlation of OER activity on the melting point of TMOs. This discovery holds significant importance for future high‐throughput material research and applications, offering valuable insights in electrocatalysis.
A Light‐Triggered J‐Aggregation‐Regulated Therapy Conversion: from Photodynamic/Photothermal Therapy to Long‐Lasting Chemodynamic Therapy for Effective Tumor Ablation
Authors: Wei Kai , Wu Yanxin , Zheng Xian , Ouyang Li , Ma Guiping , Ji Chendong , Yin Meizhen 
Published: April 2024

AbstractReactive oxygen species (ROS) have become an effective tool for tumor treatment. The combination of photodynamic therapy (PDT) and chemodynamic therapy (CDT) takes advantage of various ROS and enhances therapeutic effects. However, the activation of CDT usually occurs before PDT, which hinders the sustained maintenance of hydroxyl radicals (⋅OH) and reduces the treatment efficiency. Herein, we present a light‐triggered nano‐system based on molecular aggregation regulation for converting cancer therapy from PDT/photothermal therapy (PTT) to a long‐lasting CDT. The ordered J‐aggregation enhances the photodynamic properties of the cyanine moiety while simultaneously suppressing the chemodynamic capabilities of the copper‐porphyrin moiety. Upon light irradiation, Cu‐PCy JNPs demonstrate strong photodynamic and photothermal effects. Meanwhile, light triggers a rapid degradation of the cyanine backbone, leading to the destruction of the J‐aggregation. As a result, a long‐lasting CDT is sequentially activated, and the sustained generation of ⋅OH is observed for up to 48 hours, causing potent cellular oxidative stress and apoptosis. Due to their excellent tumor accumulation, Cu‐PCy JNPs exhibit effective in vivo tumor ablation through the converting therapy. This work provides a new approach for effectively prolonging the chemodynamic activity in ROS‐based cancer therapy.
Finding Natural, Dense, and Stable Frustrated Lewis Pairs on Wurtzite Crystal Surfaces for Small‐Molecule Activation
Authors: Yu Xi‐Yang , Huang Zheng‐Qing , Ban Tao , Xu Yun‐Hua , Liu Zhong‐Wen , Chang Chun‐Ran 
Published: April 2024

AbstractThe surface frustrated Lewis pairs (SFLPs) open up new opportunities for substituting noble metals in the activation and conversion of stable molecules. However, the applications of SFLPs on a larger scale are impeded by the complex construction process, low surface density, and sensitivity to the reaction environment. Herein, wurtzite‐structured crystals such as GaN, ZnO, and AlP are found for developing natural, dense, and stable SFLPs. It is revealed that the SFLPs can naturally exist on the (100) and (110) surfaces of wurtzite‐structured crystals. All the surface cations and anions serve as the Lewis acid and Lewis base in SFLPs, respectively, contributing to the surface density of SFLPs as high as 7.26×1014 cm−2. Ab initio molecular dynamics simulations indicate that the SFLPs can keep stable under high temperatures and the reaction atmospheres of CO and H2O. Moreover, outstanding performance for activating the given small molecules is achieved on these natural SFLPs, which originates from the optimal orbital overlap between SFLPs and small molecules. Overall, these findings not only provide a simple method to obtain dense and stable SFLPs but also unfold the nature of SFLPs toward the facile activation of small molecules.
Percutaneous mechanical thrombectomy in acute pulmonary embolism: Outcomes from a safety‐net hospital
Authors: Zhang Robert S. , Alviar Carlos L. , Yuriditsky Eugene , Alam Usman , Zhang Peter S. , Elbaum Lindsay , Grossman Kelsey , Singh Arushi , Maqsood Muhammad H. , Greco Allison A. , Postelnicu Radu , Mukherjee Vikramjit , Horowitz James , Keller Norma , Bangalore Sripal 
Published: April 2024

AbstractBackgroundOur study aims to present clinical outcomes of mechanical thrombectomy (MT) in a safety‐net hospital.MethodsThis is a retrospective study of intermediate or high‐risk pulmonary embolism (PE) patients who underwent MT between October 2020 and May 2023. The primary outcome was 30‐day mortality.ResultsAmong 61 patients (mean age 57.6 years, 47% women, 57% Black) analyzed, 12 (19.7%) were classified as high‐risk PE, and 49 (80.3%) were intermediate‐risk PE. Of these patients, 62.3% had Medicaid or were uninsured, 50.8% lived in a high poverty zip code. The prevalence of normotensive shock in intermediate‐risk PE patients was 62%. Immediate hemodynamic improvements included 7.4 mmHg mean drop in mean pulmonary artery pressure (−21.7%, p < 0.001) and 93% had normalization of their cardiac index postprocedure. Thirty‐day mortality for the entire cohort was 5% (3 patients) and 0% when restricted to the intermediate‐risk group. All 3 patients who died at 30 days presented with cardiac arrest. There were no differences in short‐term mortality based on race, insurance type, citizenship status, or socioeconomic status. All‐cause mortality at most recent follow up was 13.1% (mean follow up time of 13.4 ± 8.5 months).ConclusionWe extend the findings from prior studies that MT demonstrates a favorable safety profile with immediate improvement in hemodynamics and a low 30‐day mortality in patients with acute PE, holding true even with relatively higher risk and more vulnerable population within a safety‐net hospital.
Folliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review
Authors: Aldayhum Majed Saleh , Alshahrani Mohammed Saad , Hussein Mahmoud Rezk A. , Alshahrani Abdulmajeed Saad , Hussein Toka M. R. 
Published: April 2024

Key Clinical MessageF‐MF is a rare non‐classic variant of MF. In the case of hair loss, this should be a diagnostic consideration. The essence of the diagnosis of F‐MF is a careful medical history, physical examination, and a combination of immunohistological and molecular analyses (Cureus. 2022; 14:e21231, Ann Saudi Med. 2012; 32:283, Oman Med J. 2012; 27:134, Int J Dermatol. 2016; 55:1396, Saudi Med J. 2018; 39:994 and Case Rep Oncol. 2018; 11:436).AbstractMycosis fungoides (MF) is a primary cutaneous T‐cell lymphoma with multiple subtypes. Follicular MF (F‐MF) is a non‐classic variant of MF. Histological features entail folliculotropism and damage of the epithelium lining of the hair follicles with or without mucin deposition. A 52‐year‐old male patient complained of recurrent skin lesions on the scalp over 8 months. The lesions appeared suddenly, enlarged over time, and became itchy. A skin punch biopsy was performed. Histological features included mucin deposits in the epithelium of the hair follicles and dense, predominantly perifollicular atypical lymphocytes infiltrating the follicular epithelium. The lymphoid cells were composed of CD3‐positive T cells (CD4/CD8‐positive T cells) with a shift in favor of the former. The case was diagnosed as F‐MF on an immunohistological basis. The diagnosis of F‐MF is often difficult for dermatologists and dermatopathologists alike. Not only clinicopathological correlations but also immunohistochemical and molecular analysis are required.
Bilateral indirect ovarian inguinal hernia in a young female with type 1 Mayer–Rokitansky–Küster–Hauser syndrome: An extremely rare clinical context
Authors: Bhatta Sunil , Ojha Hemant , Ansari Meraj Alam , Shrestha Anuj 
Published: April 2024

Key Clinical MessageIncidence of bilateral inguinal hernia encompassing bilateral ovaries in adult female is very thin and concomitant association with Mayer–Rokitansky–Küster–Hauser syndrome is out of ordinary. Along with surgical management of hernia, these females need multidisciplinary slant to manage gynecological, social, and emotional issues.AbstractIn mature females, bilateral ovarian inguinal hernias are a rarity. In this situation, ultrasonography is the basic adjunct to confirm the diagnosis. Mayer–Rokitansky–Küster–Hauser syndrome is typically linked to ovarian hernias in grown‐up females. The most important ways to avoid problems are early diagnosis and surgical repair. A 25‐year‐old lady presented to our outpatient clinic with a history of swelling in bilateral inguinal region for 1 month. On the ultrasound examination, the right ovary was visualized in the right high inguinal canal, and the left ovary was seen at the level of deep inguinal ring with no visualization of the uterus in its normal anatomical position. The patient underwent bilateral inguinal exploration under spinal anesthesia, and herniated contents were successfully reduced back to anatomical locations. Clinical care for such a clinical condition must be multifaceted, involving intensive counseling, relocating the uterus, fallopian tube, and ovary to preserve fertility, and preventing consequences like incarceration and strangulation.
Body composition and late‐occurring chronic health conditions after autologous stem cell transplantation for lymphoma
Authors: Giri Smith , Harmon Christian , Landier Wendy , Chen Yanjun , Wu Jessica , Hageman Lindsey , Balas Nora , Francisco Liton , Bosworth Alysia , Weisdorf Daniel J. , Forman Stephen J. , Armenian Saro H. , Williams Grant R. , Bhatia Smita 
Published: April 2024

AbstractBackgroundAutologous peripheral blood stem cell transplantation (aPBSCT) is the standard of care for adults with relapsed lymphoma, yet recipients remain at risk of developing chronic health conditions (CHCs). It was hypothesized that body composition measurements of skeletal muscle and fat are associated with late‐onset CHCs and nonrelapse mortality after aPBSCT.MethodsLeveraging the Blood or Marrow Transplant Survivor Study, we examined association between pre‐aPBSCT body composition and new‐onset grade 3–5 CHCs among 187 adults with lymphoma treated with aPBSCT (2011–2014) surviving ≥2 years after aPBSCT. Using computed tomography scans at the L3 level, skeletal muscle mass (skeletal muscle area and skeletal muscle density [SMD]) and body fat (subcutaneous adipose tissue and visceral adipose tissue) were measured and quantified as sex‐specific z‐scores. Competing risk models were built to study the impact of body composition on incident grade 3 through 5 CHCs and nonrelapse mortality (NRM) adjusting for confounders.ResultsThe study cohort had a median age at aPBSCT of 57 years with 63% males, 77% non‐Hispanic Whites and 81% with non‐Hodgkin lymphoma. The 5‐year cumulative incidence of grade 3 through 5 CHCs was 47% (95% Confidence Interval, CI, 38%–56%). Each SD increase in SMD was associated with 30% reduced risk of grade 3 through 5 CHCs (95% CI, 0.50–0.96). The 10‐year cumulative incidence of NRM was 16% (95% CI, 10–22). No body composition measure was associated with NRM.ConclusionsThe association between SMD and grade 3 through 5 CHCs following aPBSCT could inform development of prognostic models to identify adults with lymphoma at greatest risk of morbidity following aPBSCT.
Drug‐induced liver injury as assessed by the updated Roussel Uclaf Causality Assessment Method following mild COVID‐19 in a patient under anastrozole therapy—A case report
Authors: Lischka Wolfgang , Kriegshäuser Gernot 
Published: April 2024

AbstractBackgroundAnastrozole is a selective aromatase inhibitor used for the treatment of postmenopausal hormone‐sensitive breast cancer. The major side effects include osteoporosis, hypercholesterolemia, and musculoskeletal events, such as arthralgia and myalgia. Other adverse events are rare, including symptoms of acne, masculinization, and drug‐induced liver injury, with the latter reported in a few cases only.CaseHere, we report on a patient under anastrozole therapy who developed drug‐induced liver injury as assessed by the updated Roussel Uclaf Causality Assessment Method 5 weeks after a mild SARS‐CoV‐2 infection, which is, to the best of our knowledge, the first report of its kind involving anastrozole. Discontinuation of anastrozole resulted in a marked improvement of the alanine aminotransaminase, and aspartate aminotransaminase as well as normalized lactate dehydrogenase serum levels already seen after 26 days. Surprisingly, however, the cholestatic serum markers gamma‐glutamyl transpeptidase and alkaline phosphatase showed a further rise, and took another 4 weeks to drop significantly.ConclusionThe presentation of this case is meant to alert physicians to a potential drug‐induced liver injury following mild SARS‐CoV‐2 infection in patients under anastrozole medication.
Involvement of BCR::ABL1 in laminin adhesion of Philadelphia chromosome‐positive acute lymphoblastic leukemia through upregulation of integrin α6
Authors: Takahashi Kazuya , Nguyen Thao Thu Thi , Watanabe Atsushi , Sato Hiroki , Saito Kinuko , Tamai Minori , Harama Daisuke , Kasai Shin , Akahane Koshi , Goi Kumiko , Kagami Keiko , Abe Masako , Komatsu Chiaki , Maeda Yasuhiro , Sugita Kanji , Inukai Takeshi 
Published: April 2024

AbstractBackgroundAdhesion of cancer cells to extracellular matrix laminin through the integrin superfamily reportedly induces drug resistance. Heterodimers of integrin α6 (CD49f) with integrin β1 (CD29) or β4 (CD104) are major functional receptors for laminin. Higher CD49f expression is reportedly associated with a poorer response to induction therapy in childhood B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL). Moreover, a xenograft mouse model transplanted with primary BCP‐ALL cells revealed that neutralized antibody against CD49f improved survival after chemotherapy.AimsConsidering the poor outcomes in Philadelphia chromosome (Ph)‐positive ALL treated with conventional chemotherapy without tyrosine kinase inhibitors, we sought to investigate an involvement of the laminin adhesion.Methods and resultsPh‐positive ALL cell lines expressed the highest levels of CD49f among the BCP‐ALL cell lines with representative translocations, while CD29 and CD104 were ubiquitously expressed in BCP‐ALL cell lines. The association of Ph‐positive ALL with high levels of CD49f gene expression was also confirmed in two databases of childhood ALL cohorts. Ph‐positive ALL cell lines attached to laminin and their laminin‐binding properties were disrupted by blocking antibodies against CD49f and CD29 but not CD104. The cell surface expression of CD49f, but not CD29 and CD104, was downregulated by imatinib treatment in Ph‐positive ALL cell lines, but not in their T315I‐acquired sublines. Consistently, the laminin‐binding properties were disrupted by the imatinib pre‐treatment in the Ph‐positive ALL cell line, but not in its T315I‐acquired subline.ConclusionBCR::ABL1 plays an essential role in the laminin adhesion of Ph‐positive ALL cells through upregulation of CD49f.
A cross‐sectional study of sleep disturbance among middle‐aged cancer patients at Vietnam National Cancer Hospital
Authors: Pham Anh Tuan , Do Mai Tuyet , Tran Huong Thi Thanh 
Published: April 2024

AbstractAimSleep disorders are common in cancer patients and have negative consequences for patient well‐being and treatment outcomes. This study aimed to investigate sleep quality and related factors in Vietnamese middle‐aged cancer patients.MethodsA cross‐sectional study was conducted on 246 middle‐aged in‐patient cancer patients at Vietnam National Cancer Hospital (VNCH) from 1/2021 to 7/2021. Sleep was measured by the Pittsburgh Sleep Quality Index (PSQI), with a cutoff of 5.ResultsThe results showed a male/female ratio of 0.85 with an average age of 52. The five most prevalent cancer types were breast, colorectal, lung, and esophagus‐stomach cancer, primarily in the late stage and treated with chemotherapy. The prevalence of sleep disturbances was 58.5%. The mean PSQI score was 7.5, with sleep duration and latency of 5.4 h and 1 h, respectively. Approximately 44% of participants reported poor sleep quality, nearly 9% had daytime dysfunction, and 10.6% used sleep medication. The multivariate logistic regression results indicate that people with depression were 8.89 times more likely to have poor sleep than those without depression (95% CI:2.63–28.27, p < .001).ConclusionSleep problems are common among middle‐aged people with cancer in Vietnam, especially individuals with depression. It is necessary to have more effective approaches to sleep management for cancer patients with limited resources.
An ELISA‐Based Method to Measure Mucosal Antibody Responses Against SARS‐CoV‐2 in Human Saliva
Authors: Bhavsar Disha , Sano Kaori , Singh Gagandeep , Krammer Florian 
Published: April 2024

AbstractThe primary mode of transmission for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is infection of the respiratory tract through droplets and/or aerosols. Therefore, immune responses at respiratory mucosal surfaces play a significant role in the prevention of infection. Greater emphasis is now being placed on mucosal immunity induced by exposure to SARS‐CoV‐2 antigens through infection or vaccination. In concert with cellular immunity, humoral responses at mucosal surfaces, especially the secretory version of immunoglobulin A (sIgA), can be instrumental in preventing respiratory infections. A better understanding of mucosal immune responses can further our knowledge of immunity to SARS‐CoV‐2 and help inform vaccine design. Here we describe a detailed protocol for an in vitro assay based on the enzyme‐linked immunosorbent assay (ELISA) to assess mucosal antibody response to SARS‐CoV‐2 spike protein in human saliva. © 2024 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol: ELISA measurement of mucosal antibodies to SARS‐CoV‐2 spike protein in human saliva
The usefulness of texture and color enhancement imaging to identify the minor papilla orifice
Authors: Goda Yoshihiro , Irie Kuniyasu , Anan Hideyuki , Suzuki Yuichi , Ikeda Aya , Ikeda Ryosuke , Kaneko Hiroaki , Sue Soichiro , Miwa Haruo , Maeda Shin 
Published: April 2024

AbstractIn clinical cases of pancreas divisum, endoscopic retrograde cholangiopancreatography often necessitates cannulation of the pancreatic duct through the minor papilla. Nevertheless, this procedure can be challenging because of the small size of the minor papilla and the difficulty in visualizing the ductal orifice. A new image‐enhanced endoscopy technique called texture and color enhancement imaging (TXI) has been developed, which enhances texture, brightness, and color compared with white‐light imaging, resulting in subtle differences in the surface mucosa. Herein, we describe the case of a 73‐year‐old man with pancreas divisum in whom TXI was useful in identifying the orifice of the minor papilla. He was referred to our hospital with repetitive acute exacerbation of chronic pancreatitis. Since contrast‐enhanced computed tomography revealed a pancreatic stone in the main pancreatic duct, endoscopic retrograde cholangoepancreatography was performed as a therapeutic intervention. Despite the initial difficulty in identifying the orifice of the minor papilla on white‐light imaging, TXI enhanced its visibility successfully, enabling dorsal pancreatic duct cannulation via the minor papilla. Subsequently, endoscopic pancreatic sphincterotomy was performed and a 6Fr plastic stent was placed. Post‐endoscopic therapy, the patient's abdominal pain was relieved. TXI was useful in identifying the minor papilla orifice and led to successful cannulation.
Incidence and predictors of heart failure with reduced and preserved ejection fraction after ST‐elevation myocardial infarction in the contemporary era of early percutaneous coronary intervention
Authors: Lenselink Chris , Ricken Kim W.L.M. , Groot Hilde E. , de Bruijne Tijs J. , Hendriks Tom , van der Harst Pim , Voors Adriaan A. , Lipsic Erik 
Published: April 2024

AbstractAimsThe development and incidence of de‐novo heart failure after ST‐elevation myocardial infarction (STEMI) in the contemporary era of rapid reperfusion are largely unknown. We aimed to establish the incidence of post‐STEMI heart failure, stratified by left ventricular ejection fraction (LVEF) and to find predictors for its occurrence. Furthermore, we investigated the course of left ventricular systolic and diastolic function after STEMI.Methods and resultsA total of 1172 all‐comer STEMI patients from the CardioLines Biobank were included. Patients were predominantly male (74.5%) and 64 ± 12 years of age. During a median follow‐up of 3.7 years (2.0, 5.5) we found a total incidence of post‐STEMI heart failure of 10.9%, of which 52.1% heart failure with reduced ejection fraction (HFrEF), 29.4% heart failure with mildly reduced ejection fraction and 18.5% heart failure with preserved ejection fraction (HFpEF). Independent predictors for the development of HFrEF were male sex (β = 0.97, p = 0.009), lung crepitations (β = 1.09, p = 0.001), potassium level (mmol/L, β = 0.43, p = 0.012), neutrophil count (109/L, β = 0.09, p = 0.001) and a reduced LVEF (β = 1.91, p < 0.001) at baseline. Independent predictors for the development of HFpEF were female sex (β = 0.99, p = 0.029), pre‐existing kidney failure (β = 1.95, p = 0.003) and greater left atrial volume index (β = 0.04, p = 0.033) at baseline. Follow‐up echocardiography (median follow‐up 20 months) showed an improvement in LVEF (p < 0.001), whereas changes in diastolic function parameters showed both improvement and deterioration.ConclusionIn the current era of early STEMI reperfusion, still one in 10 patients develops heart failure, with approximately half of the patients with a reduced and half with a mildly reduced or normal LVEF. Predictors for the development of HFrEF were different from HFpEF.
Chiral resolution of cationic piperazine derivatives by capillary electrophoresis using sulfated β‐cyclodextrin
Authors: Niaei Navid , Hassanpour Soodabeh , Petr Jan 
Published: April 2024

AbstractThis research focuses on the development and validation of a capillary electrophoresis (CE) method for the chiral separation of three H1‐antihistamine drugs chlorcyclizine, norchlorcyclizine, and neobenodine using sulfated β‐cyclodextrin (S‐β‐CD) as the chiral selector. The study explores various factors influencing the separation efficiency, including CD concentration, organic modifier content, voltage application, and buffer pH. Optimal conditions were identified as a 100 mM phosphate buffer (pH 6.0) with 34 mg mL–1 S‐β‐CD and 40% (v/v) methanol. The method demonstrated excellent linearity in calibration curves, with coefficients of determination exceeding 0.99 for each enantiomer. Precision studies revealed good intra‐ and inter‐day precision for migration times and peak areas. The limits of detection and quantification for the analytes were within the ranges of 5.9–11.4 and 18–34.6 µmol L–1, respectively. Overall, the developed CE method offers a robust and precise approach for the chiral separation of H1‐antihistamine drugs, holding promise for pharmaceutical applications.