bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fragmentary Statue from Caesarea Maritima
Authors: Gersht Rivka 
Published: February 2025

Three possible identifications — Aphrodite, Hermes, Apollo — are considered for the fragmentary statue showing two feet poised on a tortoise, which was pulled out of sea northward of the theater of Caesarea Maritima. Written sources and archaeological finds indicate that images of Aphrodite, Hermes, and Apollo accompanied by a tortoise were known since the Archaic period, but only Aphrodite and Apollo were shown standing with two feet upon a tortoise.
Greek (and Christian?) Sources in Ibn Ezra’s Commentary on Psalms
Authors: Wasserstein A. 
Published: February 2025

This article observes that in his commentary on Psalms Abraham ibn Ezra interprets Psalm 19 in a manner reminiscent of Plato’s simile of the sun in Republic 6, and possibly also the parable of the cave. It proceeds to examine the possibility that Platonic influence on ibn Ezra derives not from Plato’s own work but from that of Philo, and that ibn Ezra was familiar with patristic and Philonic exegesis.
A COMPREHENSIVE ANALYSIS OF CONSUMER SATISFACTION WITH MASALA PRODUCTS IN ANDHRA PRADESH
Authors: Venkata ashwath reddy  , Kiranmayi Patel  
Published: February 2025

The study explores consumer satisfaction with masala products in Andhra Pradesh, emphasizing the dynamics of purchasing behaviour and preferences for packaged and loose masalas. Employing a descriptive research design, it integrates primary data collected through structured questionnaires and secondary data from credible sources to identify key factors influencing consumer choices, such as taste, price, packaging, and availability. Statistical tools, including chi-square tests, were used to analyse the relationships between demographic variables and satisfaction levels. The findings underscore a dominant preference for packaged masalas due to their convenience, quality, and reliability, while local homemade variants hold significance among select consumer segments. The study's outcomes highlight the importance of aligning product innovation, quality assurance, and targeted marketing strategies to enhance consumer loyalty and satisfaction. This comprehensive analysis offers valuable insights into the evolving preferences of masala consumers, providing actionable recommendations for stakeholders in the food and spice industry.
Mabeob, Nyankomade, Salamangka: Illustrating the Intersection of Medicine, Diversity, and Ethics in Three Original Comics set in Korea, Ghana, and the Philippines
Authors: Ryu Grace Soojin , Pino Anne Francine , Bonsu Edna , Sim Hyelim , Vinluan Amber , Myers Kimberly 
Published: February 2025

This manuscript discusses medical students’ experience of co-authoring three medical ethics-based comics inspired by their respective Korean, Ghanaian, and Filipino backgrounds. Shaping Beauty, Best Medicine, and Conflicting Covenants are a part of the increasingly popular field of Graphic Medicine, defined as the “intersection between the medium of comics and the discourse of healthcare” (Williams, 2021). Targeting the international Graphic Medicine audience and medical learners, we explore distinct medical ethical dilemmas in sample panels from each comic. Subsequently, we share insights about how these interprofessional, international collaborations have impacted us as students who are training to become competent and compassionate physicians. This developmental process, known as Professional Identity Formation (PIF), is defined as a gradual transformation while integrating values, relationships, roles, and responsibilities (Sarraf-Yazdi et al., 2024). This process is partly conscious, as when students seek experiences that will help them embody the clinical skills and ethical sensitivity of their role models; at other times, PIF is more a product of the “hidden curriculum,” where students intuitively learn the mores of medical culture largely through exposure to it (Green &amp; Myers, 2010; Green et al., 2017). We discovered during this two-year-long project that Graphic Medicine serves as a novel educational modality that bridges the gap between our lived experiences and those of individuals from different cultures.
Vers de nouvelles approches en santé mentale : possibilités et limites pour les francophones en situation minoritaire à Terre-Neuve-et-Labrador et aux Territoires du Nord-Ouest
Authors: Savard Sébastien , van Kemenade Solange , Bouchard Louise , Savard Jacinthe , Oukouomi D. Ghisleine , Michel Jean Nephetaly 
Published: February 2025

De nouvelles approches axées sur la cybersanté mentale l’aide à la navigation du système, les cliniques sans rendez-vous, ainsi que les approches plus traditionnelles comme les lignes d’aide et de crise cohabitent afin de promouvoir ou d’intervenir précocement en santé mentale. Comment ces interventions répondent-elles aux besoins des francophones en contexte linguistique minoritaire alors que la communication est au coeur d’une consultation réussie? Objectif : Documenter six initiatives à Terre-Neuve-et-Labrador et dans les Territoires du Nord-Ouest. Méthode : Études de cas, incluant trente-six entrevues semi-dirigées auprès des autorités sanitaires, des fournisseurs de soins et des usagers. Résultats : La gratuité, l’anonymat, la rapidité, la présence des pairs travailleurs, l’absence de jugement et des démarches simples facilitent l’accès aux programmes. Parmi les limites, l’insuffisance de services en français et l’accent sur les thérapies brèves peuvent affecter la continuité des services, notamment pour les usagers francophones. Conclusion : Malgré les efforts pour améliorer l’offre de services en santé mentale aux francophones, des lacunes subsistent. L’article présente certaines stratégies qui permettraient d’améliorer l’offre de ces services.
Expérimentation de la communauté de pratique en tant que stratégie de mobilisation de connaissances scientifiques dans le champ social
Authors: Bilodeau Angèle , St-Louis Marie-Pier , Morin Lucie , Johnson Rebecca , Parent André-Anne , Racine Sonia , Chapeau Jean-Marie , Potvin Louise 
Published: February 2025

La mobilisation des connaissances scientifiques par la connexion réciproque et continue entre producteurs et utilisateurs de connaissances est un champ en expansion. La communauté de pratique (CdeP) y figure comme une stratégie avancée de mobilisation et de mise en action des connaissances. La CdeP peut être intentionnelle, c.-à-d. pilotée par un organisme ayant des attentes signifiées envers le milieu de pratique. Deux CdeP intentionnelles initiées par des chercheurs ont été expérimentées sur un an pour soutenir la mobilisation de connaissances scientifiques et d’instruments d’application dans le domaine de l’action intersectorielle. Les membres provenaient d’instances intersectorielles du Québec, pour l’une, et du Canada anglais, pour l’autre. La capacité des CdeP à atteindre les résultats anticipés a été évaluée à partir des données d’opération. Les variables documentées ont été le profil et l’intérêt des membres; les activités réalisées; l’appropriation et l’utilisation des connaissances et instruments; les besoins des participants à cet effet. Une description chronologique par CdeP a été suivie d’une analyse comparative des CdeP. Les résultats ont été : 1) l’appropriation et l’utilisation des connaissances et instruments et le partage d’expériences et de nouvelles pratiques entre les participants; 2) l’amorce de l’expérimentation au sein de leurs instances de provenance. Une pleine application au sein des instances n’a pu être réalisée en raison de la durée et des ressources limitées, mais aussi en raison de la difficulté des CdeP, communément dédiées au partage entre leurs membres, à se repositionner en tant que mécanisme de mobilisation des connaissances orienté vers les réseaux d’utilisateurs à soutenir.
First Report and Morphological Study of Paraplagusia bilineata (Bloch, 1787) in the Arabian Sea, Gujarat, Northwest Coast of India
Authors: Borichangar Ritesh V. , Parmar Jeet N. , Bharda Sheetal K. , Tandel Bhavika R. , Tandel Lata V. , D. Vyas Upasana 
Published: February 2025

The present study reports an additional record of the rare flatfish, Double lined tongue sole Paraplagusia bilineata (Cyanoglossidae), off Dholai fishing harbour, Gujarat, India. One specimen was caught in a trawl net at a depth of 30–32 m around the coast of Gujarat. The total length and weight of the specimen were recorded as 20.4 cm and 60.5 g, respectively. In total, 18 morphometric parameters were closely observed and recorded for the taxonomic identification and confirmation of the species using morphometric analysis with traditional morphometrics. Paraplagusia bilineata is categorized as ‘Least Concern’ in the IUCN Red List, with the latest assessment conducted in 2021. Previously, P. bilineata was not reported in Gujarat. This study serves as the initial report of the presence of Paraplagusia bilineata from Dholai fishing harbour, Gujarat, on the Northwest coast of India.
Potential Anti-hyperglycemic Activity of the Polyherbal Combination of Carica papaya L., Persea americana Mill., and Theobroma cacao L. Leaves Extract: In vitro, Ex vivo, In vivo Studies
Authors: Dackey Yawa Fernadette Clara , Hanvi Dédé Mawulé , Motto Aku Enam , Atchou Kokou , Lawson-Evi Povi , Eklu-Gadegbeku Kwashie 
Published: February 2025

Aims: The present study evaluated the potential anti-hyperglycemic activity of a traditional recipe from Togo, consisting of C. papaya L., and P. Americana Mill. and T. cacao L., commonly used to treat diabetes.
Study design: In vivo, Ex vivo, and In vitro approaches were utilized.
Place and Duration of Study: the research was conducted from April to December 2022. At the Laboratory of Physiology/Pharmacology, Unit of Pathophysiology, Bioactive Substances and Safety, Faculty of Sciences, University of Lomé.
Methodology: Ethanol/water (50:50, v/v) extract from 600 g of an equivalent proportion of dry leaves, was used at different doses of 100, 200, and 400 mg. kg -1. The In vivo Oral Glucose Tolerance Test was performed on mice using an Accu Check Active glucometer and metformin as a standard reference drug. An investigation on possible mechanisms of action, undertaken the Ex vivo inhibition of intestinal glucose absorption and skeletal muscle glucose uptake. The total antioxidant and DPPH free radicals scavenging tests were also performed. The phytochemical and physicochemical were respectively processed by spectrophotometer colorimetric assays and atomic absorption spectrometry.
Results: The extract of the recipe at 200 and 400 mg. kg -1 exerted a significant (p < 0.001) decrease in hyperglycemia in a dose-dependent manner after 120 minutes. However, at 400 mg. kg -1 which is the efficient dose, the extract did not significantly reduce basal glucose level in mice. The CPT extract inhibited intestinal glucose absorption and enhanced glucose uptake in skeletal muscles. The extract also scavenged DPPH free radicals in a dose-dependent manner and demonstrated an important total antioxidant capacity. Phytochemical and physicochemical analyses revealed that the extract contained an important quantity of phenolic compounds, flavonoids, tannins, polysaccharides, and essential minerals such as calcium, magnesium, zinc, potassium, and sodium.
Conclusion: The study demonstrated the anti-hyperglycemic and antioxidant activities of the CPT recipe, which scientifically supports its traditional use in treating diabetes and complications in Togo. Further research is warranted to explore the full potential of the CPT recipe.
Enhanced Chemoradiotherapy for MRSA‐Infected Osteomyelitis Using Immunomodulatory Polymer‐Reinforced Nanotherapeutics
Authors: Zhang Yufei , Cheng Yijie , Zhao Zhe , Jiang Shengpeng , Zhang Yuhan , Li Jie , Huang Siyuan , Wang Wenbo , Xue Yun , Li Anran , Tao Zhen , Wu Zhongming , Zhang Xinge 
Published: February 2024

AbstractThe eradication of osteomyelitis caused by methicillin‐resistant Staphylococcus aureus (MRSA) poses a significant challenge due to its development of biofilm‐induced antibiotic resistance and impaired innate immunity, which often leads to frequent surgical failure. Here, the design, synthesis, and performance of X‐ray‐activated polymer‐reinforced nanotherapeutics that modulate the immunological properties of infectious microenvironments to enhance chemoradiotherapy against multidrug‐resistant bacterial deep‐tissue infections are reported. Upon X‐ray radiation, the proposed polymer‐reinforced nanotherapeutic generates reactive oxygen species and reactive nitrogen species. To robustly eradicate MRSA biofilms at deep infection sites, these species can specifically bind to MRSA and penetrate biofilms for enhanced chemoradiotherapy treatment. X‐ray‐activated nanotherapeutics modulate the innate immunity of macrophages to prevent the recurrence of osteomyelitis. The remarkable anti‐infection effects of these nanotherapeutics are validated using a rat osteomyelitis model. This study demonstrates the significant potential of a synergistic chemoradiotherapy and immunotherapy method for treating MRSA biofilm‐infected osteomyelitis.
A New Polymeric Minimally Invasive Glaucoma Implant
Authors: Pereira Inês C.F. , Bartels Paul A.A. , Bertens Christian J.F. , Söntjens Serge H.M. , Wyss Hans M. , Schenning Albertus P.H.J. , Dankers Patricia Y.W. , Beckers Henny J.M. , den Toonder Jaap M.J. 
Published: February 2024

AbstractGlaucoma drainage devices are implanted in the eye to treat glaucoma, a disease that can cause vision loss and blindness. These devices are designed to reduce intraocular pressure (IOP), a major risk factor for the progression of glaucoma, by providing an alternative outflow path for the fluid produced by the eye, the aqueous humor. Here, a novel polymeric minimally invasive glaucoma implant designed to enhance aqueous humor outflow is demonstrated. The implant is made of a unique, potentially biodegradable thermoplastic material, polycarbonate bisamide (PC‐BA), and produced through replica molding using hot embossing and femtosecond laser‐machined glass molds. Post‐mortem experiments demonstrate successful device implantation into a rabbit's eye, with the implant remaining securely in place. Although the mass loss and changes in molecular weight observed in the in vitro degradation experiments are not significant within the tested times and degradation conditions, the PC‐BA is a slow‐degradation polymer that may take a few years to fully degrade. Thus, the implant will also slowly degrade and be absorbed by the body over time, leaving behind a natural outflow pathway. This potentially biodegradable glaucoma implant may represent a promising new approach for restoring outflow in a more natural way.
Development of Cyanopyridazine Derivatives as Photoredox Catalysts and Evaluation of their Catalytic Performance
Authors: Tang Yinhong , Liu Yan , Zhu Peng , Pang Junsen , Peng Yungui 
Published: February 2024

AbstractAn array of cyanopyridazine derivatives have been developed through a sequence of (3+3) cycloaddition/oxidative aromatization/derivatization steps. Investigation of the physicochemical properties of these compounds shows that four have interesting fluorescence properties and have the potential to be developed into bimodal photoredox catalysts. One has been confirmed to be an photoredox catalyst in the reactions of N‐aryl‐ tetrahydroisoquinolines with phosphite, nitromethane, malonitrile and sodium thiocyanate, led to 22%–95% yields. The catalyst capabilities remain with recyclable using under the reaction conditions.
Hierarchical Self‐Assembly Molecular Building Blocks as Intelligent Nanoplatforms for Ovarian Cancer Theranostics
Authors: Li Shuo , Chen Qingrong , Xu Qi , Wei Zhongyu , Shen Yongjin , Wang Hua , Cai Hongbing , Gu Meijia , Xiao Yuxiu 
Published: February 2024

AbstractHierarchical self‐assembly from simple building blocks to complex polymers is a feasible approach to constructing multi‐functional smart materials. However, the polymerization process of polymers often involves challenges such as the design of building blocks and the drive of external energy. Here, a hierarchical self‐assembly with self‐driven and energy conversion capabilities based on p‐aminophenol and diethylenetriamine building blocks is reported. Through β‐galactosidase (β‐Gal) specific activation to the self‐assembly, the intelligent assemblies (oligomer and superpolymer) with excellent photothermal and fluorescent properties are dynamically formed in situ, and thus the sensitive multi‐mode detection of β‐Gal activity is realized. Based on the overexpression of β‐Gal in ovarian cancer cells, the self‐assembly superpolymer is specifically generated in SKOV‐3 cells to achieve fluorescence imaging. The photothermal therapeutic ability of the self‐assembly oligomer (synthesized in vitro) is evaluated by a subcutaneous ovarian cancer model, showing satisfactory anti‐tumor effects. This work expands the construction of intelligent assemblies through the self‐driven cascade assembly of small molecules and provides new methods for the diagnosis and treatment of ovarian cancer.
Treatment of Acute Wound Infections by Degradable Polymer Nanoparticle with a Synergistic Photothermal and Chemodynamic Strategy
Authors: Chen Fangzhou , Liu Lin , Tang Dongsheng , Zhang Hanchen , Wu Nier , Wang Lin , Li Hongbo , Xiao Haihua , Zhou Dongsheng 
Published: February 2024

AbstractMild‐heat photothermal antibacterial therapy avoids heat‐induced damage to normal tissues but causes bacterial tolerance. The use of photothermal therapy in synergy with chemodynamic therapy is expected to address this issue. Herein, two pseudo‐conjugated polymers PM123 with photothermal units and PFc with ferrocene (Fc) units are designed to co‐assemble with DSPE‐mPEG2000 into nanoparticle NPM123/Fc. NPM123/Fc under 1064 nm laser irradiation (NPM123/Fc+NIR‐II) generates mild heat and additionally more toxic ∙OH from endogenous H2O2, displaying a strong synergistic photothermal and chemodynamic effect. NPM123/Fc+NIR‐II gives >90% inhibition rates against MDR ESKAPE pathogens in vitro. Metabolomics analysis unveils that NPM123/Fc+NIR‐II induces bacterial metabolic dysregulation including inhibited nucleic acid synthesis, disordered energy metabolism, enhanced oxidative stress, and elevated DNA damage. Further, NPM123/Fc+NIR‐II possesses >90% bacteriostatic rates at infected wounds in mice, resulting in almost full recovery of infected wounds. Immunodetection and transcriptomics assays disclose that the therapeutic effect is mainly dependent on the inhibition of inflammatory reactions and the promotion of wound healing. What is more, thioketal bonds in NPM123/Fc are susceptible to ROS, making it degradable with highly favorable biosafety in vitro and in vivo. NPM123/Fc+NIR‐II with a unique synergistic antibacterial strategy would be much less prone to select bacterial resistance and represent a promising antibiotics‐alternative anti‐infective measure.
Controlling Sodium Dendrite Growth via Grain Boundaries in Na3Zr2Si2PO12 Electrolyte
Authors: Gao Zhonghui , Bai Yang , Feng Junrun , Yang Jiayi , Liu Porun , Yuan Haiyang , Guan Xuze , Wang Feng Ryan , Huang Yunhui 
Published: February 2024

AbstractNa3Zr2Si2PO12(NZSP)‐based NASICON solid‐state electrolytes (SSEs) show not only competitive ionic conductivity but also high chemical stability in air, holding a great promise for enabling the use of sodium metal anode in solid‐state sodium batteries. However, sodium (Na) metal dendrite growth inside SSE always leads to undesirable short‐circuiting in battery even no obvious changes in interfacial contact loss and interfacial decomposition during cycling. How to control Na metal dendrite growth and in situ observe the effect of SSE/Na interface change on dendrite growth is quite challenging. Herein, an in situ synchrotron‐based X‐ray imaging method is developed to systematically investigate the dendrite origin in NZSP‐based SSEs. It is find that the dendrite growth intrinsically depends on the grain boundaries (GBs) in NZSP and the NZSP/Na interfacial properties. It is confirmed that Na dendrite infiltration kinetic evolution in NZSP is strongly associated with Na ion/electron conductivity and Young's modulus of GBs. Moreover, the electro‐chemo‐mechanical phase‐field model evaluation demonstrates that the basic reason for Na metal dendrite intrusion into the GBs of SSE is a combination of local polarization potential and the presence of stress formed at GBs.
Identification of a novel splice‐site WWOX variant with paternal uniparental isodisomy in a patient with infantile epileptic encephalopathy
Authors: Nishino Megumi , Tanaka Mai , Imagawa Kazuo , Yaita Katsuyuki , Enokizono Takashi , Ohto Tatsuyuki , Suzuki Hisato , Yamada Mamiko , Takenouchi Toshiki , Kosaki Kenjiro , Takada Hidetoshi 
Published: February 2024

AbstractWOREE syndrome is an early infantile epileptic encephalopathy characterized by drug‐resistant seizures and severe psychomotor developmental delays. We report a case of a WWOX splice‐site mutation with uniparental isodisomy. A 1‐year and 7‐month‐old girl presented with nystagmus and epileptic seizures from early infancy, with no fixation or pursuit of vision. Physical examination revealed small deformities, such as swelling of both cheeks, folded fingers, rocking feet, and scoliosis. Brain imaging revealed slight hypoplasia of the cerebrum. Electroencephalogram showed focal paroxysmal discharges during the interictal phase of seizures. Vitamin B6 and zonisamide were administered for early infantile epileptic encephalopathy; however, the seizures were not relieved. Despite altering the type and dosage of antiepileptic drugs and ACTH therapy, the seizures were intractable. Whole‐exome analysis revealed the homozygosity of WWOX(NM_016373.4):c.516+1G>A. The WWOX mRNA sequencing using peripheral blood RNA confirmed that exon 5 was homozygously deleted. Based on these results, the patient was diagnosed with WOREE syndrome at 5 months. The WWOX variant found in this study is novel and has never been reported before. WOREE syndrome being extremely rare, further case series and analyses of its pathophysiology are warranted.
Electrically conductive bioplastics based on chitosan, polyvinyl alcohol, polyvinyl pyrrolidone, and plant extract nanoparticles for detecting Rhizopus stolonifer on tomato fruit
Authors: Flores‐Salgado Anallely , Antúnez‐García Edgar , Bautista‐Baños Silvia , Munguia‐Cervantes Jacobo Esteban , Mendoza‐Acevedo Salvador , Hernández‐López Mónica , Zavaleta‐Avejar Leonor , Correa‐Pacheco Zormy Nacary , Ventura‐Aguilar Rosa Isela 
Published: February 2024

AbstractThis work aimed to manufacture bioplastics with mechanical and electrical properties for monitoring the Rhizopus stolonifer growth in tomato fruit packaging. Bioplastics were based on chitosan/polyvinyl alcohol (Ch/PVA), chitosan/polyvinyl pyrrolidone (Ch/PVP), and nanoparticles (NPs) of plant extracts at 10% and 30% of concentrations. Bioplastics were exposed to tomato inoculated with R. stolonifer for 6 d at 25°C. Water vapor permeability (WVP), mechanical properties, FTIR, UV–vis, morphology, electrical resistance of bioplastics, and the NPs size were assessed. In bioplastics added with plant extracts, 1.5 times more WVP than in the control group (18–35 gs−1m−1Pa−1) were quantified. Ch/PVA bioplastic showed 51% more tensile strength, 44% more elongation at break, and 40% more Young's modulus than Ch/PVP, regardless of the plant extract. The electrical resistance in Ch/PVA bioplastics with 30% mushroom extract and 10% radish allowed the differentiation between inoculated (109–1010 Ω) and non‐inoculated tomatoes (1010–1011 Ω). The FTIR assay confirmed the presence of each compound used in the bioplastic, and UV–vis confirmed phenols at 300 nm. The NPs measured less than 50 nm. Only Ch/PVA with 30% mushroom and 10% radish can be useful to monitor fungi in tomatoes based on their electrical behavior.