bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hematologic Recovery in Pediatric Patients with Acute Lymphoblastic Leukemia After Induction Chemotherapy
Authors: Wicaksono Sony , Andarsini Mia Ratwita , Ugrasena I Dewa Gede , Cahyadi Andi , Larasati Maria Christina Shanty , Nugroho Susanto 
Published: March 2024

Link of Video Abstract: https://youtu.be/ulLjSscae2Q

Introduction: Myelosuppression in Acute Lymphoblastic Leukemia (ALL) children was associated with high morbidity and mortality. Chemotherapy was aimed to achieve remission conditions, including the elimination of blast cells in the bone marrow. However, the evidence of hematologic recovery after induction chemotherapy was poorly described. This study aimed to evaluate the profile of peripheral blood and the outcome of children with ALL after induction chemotherapy.
Methods: A prospective study was conducted in the Hematology-Oncology Pediatric Department at Saiful Anwar Hospital Malang. Patients <15 years old who were newly diagnosed as ALL were enrolled in this study. Peripheral blood examinations were performed on the 1st, 2nd, 4th, and 6th weeks. Clinical outcomes were evaluated by remission status. Comparison and correlation analysis were done by IBM SPSS for Windows, version 26. P-value <0,05 was considered significant.
Result: There were 27 children included in this study. The median age was 5 years. There were 15 males and 17 females, 18 patients with LLA-L2 and 9 patients with LLA-L1. All patients received chemotherapy regimens according to the 2018 National Protocol for ALL. The median hemoglobin level was significantly increased after induction chemotherapy (p< 0.05). Meanwhile, the reticulocyte count increased in the 2nd week after induction chemotherapy. The Absolute Neutrophil Count (ANC) significantly improved and reached the normal limit in 4th week after chemotherapy induction. The platelet count and Immature Platelet Fraction (IPF) also increased significantly (p< 0.05) and reached the normal limit in 4th week after induction of chemotherapy.
Conclusion: Three cell lines regenerate at different rates at induction chemotherapy, with rapid erythrocyte recovery and slow neutrophil and platelet recovery.
Bacterial profile and antimicrobial sensitivity pattern of blood specimen isolates in patients with bacteremia in the intensive care unit at Dr. Soetomo Hospital
Authors: Ayu Permatasari Tribuana Tungga Dewi  , Mertaniasih Ni Made , Bambang Pujo Semedi  , Manik Retno Wahyunitisari  , Eko Budi Koendhori  
Published: March 2024

Link of Video Abstract: https://youtu.be/2wcFE-82J2s

Background: Critically ill patients in intensive care have a higher predisposition to acquire bacterial infections in the bloodstream. Research on bacterial profiles and blood culture sensitivity patterns in bacteremia patients can provide information for the basis of diagnosis, approaches, and treatment strategies in patients. To better understand the microbial profile and pattern of antimicrobial sensitivity of blood specimen isolate among non-COVID patients in the intensive care unit, we evaluated data from medical records that included blood cultures for all participants in the intensive care unit from January 2019 to April 2022.
Method: A retrospective observational study with a cross-sectional approach was conducted in the Clinical Microbiology Department and Medical Record Unit at Dr. Soetomo Hospital. Data on surgical and non-surgical noncovid patients with bacteremia in intensive care unit patients was collected from January 2019 to April 2022. The Sample was taken with a consecutive sampling technique.
Results: There were 140 isolates with positive blood culture results. The most common bacteria are coagulase-negative Staphylococcus 22 (15.7%), Acinetobacter baumanii 25 (17.9%), and Pseudomonas aeruginosa 13 (4.9%) in surgical and non-surgical patients. Sensitivity to Gram-positive bacteria in surgical and non-surgical patients before the pandemic linezolid 75% and vancomycin 58,3%. During pandemic linezolid at 76.9% and vancomycin at 69.2%. Sensitivity of Gram-negative bacteria in surgical patients before the pandemic was imipenem 57.1%, meropenem 57.1%, and amikacin 47.6%. During the pandemic, amikacin 73.5%, meropenem 55.1%, and imipenem 53.1%. Non-surgical patients before the pandemic gram negative sensitivity to meropenem was 100%, ceftazidime 66.7%. During the pandemic, amikacin 59.1%, and cotrimoxazole 45.5%.
Conclusion: There was no difference in the surgical and non-surgical bacterial profiles before the pandemic and during the pandemic.
Atrial septal defect occluder devices and embolization – a case series
Authors: Ambarsari Yuletta Adny , Novenanto Tandean Tommy , Susantya Dicky Panditatwa , Supomo Supomo , Aribowo Haryo , Kurnia Yunanto , Amal Ihsanul , Satriotomo Irawan 
Published: March 2024

Introduction: Atrial Septal Defect (ASD) secundum is a commonly occurring congenital heart disease. Patients with unstable hemodynamic may require closure, which can be accomplished either percutaneous transcatheter of an atrial septal occluder (ASO) device or open surgery. Closure using an occluder carries the risk of device embolization (DE).
Case Presentation: This case series presents two patients who had dislodgement after ASD closure using ASO. The demographic data, comorbidities, surgical details, and follow-up results are all summarized. A 9-year-old girl and a 12-year-old boy admitted to our centre. The girl echocardiography evaluation revealed dislodgment of ASD occluder in a large secundum ASD, right upper PV blockage, and a high chance of pulmonary hypertension (PH). While the boy showed the occluder device that was misplaced and positioned in the right ventricle. A secundum ASD with a left to right shunt and moderate TR with a peak pressure gradient of 21.5mmHg were also found. During the procedure, we discovered that the girl had an occluder in the superior rim of ASD II 3x2 cm, which was dislodged towards the lower right PV, above the mitral valve, and the posterior occluder leaflet was removed by replacing a section of the rim. We discovered a secundum ASD with a dimension of 2x1cm on the boy The occluder was found behind the anterior cusp of the tricuspid valve. The retrieved occluder device appeared intact, and the tricuspid valve was injured, but no rupture.
Conclusion: The occurrence of ASO migration is uncommon, necessitating further surgery for device removal, closure of the remaining defect, and ensure there is no cardiac erosion or rupture. Surgery can also alleviate symptoms including shortness of breath and palpitations
Follow-up evaluation of snuffbox arteriovenous fistula as an alternative site for hemodialysis - a case series in a lower-middle country
Authors: Kurnia Yunanto , Trianingsih Trianingsih , Novenanto Tandean Tommy , Supomo Supomo , Aribowo Haryo , Ambarsari Yuletta Adny , Amal Ihsanul 
Published: March 2024

Link of Video Abstract: https://youtu.be/MSeO8kuKhGc

Introduction: The preferred vascular access for hemodialysis in chronic kidney disease patients is the arteriovenous fistula (AVF). It is recommended to create AVFs as distally as possible. The snuffbox, situated at the far end of the wrist, is infrequently utilized for AVF insertion due to the prevalent smaller vessel calibers.
Case: This case series involves seven patients with chronic kidney disease scheduled for first AVF placement in the snuffbox region, with an average age of 56.71 years. All patients showed an average radial artery caliber of 20.3mm, a mean peak systolic velocity of 67.14 cm/s, and a cephalic vein caliber of 22.7mm, according to preoperative vascular ultrasound. The AVF placement involved an end-to-side anastomosis. All patient demonstrated anastomosis clinical maturation, the primary patency rate was 86%. Follow-up Doppler examinations revealed that patients achieving functional patency had an average caliber of 5.22mm and an average flow rate of 810.65 ml/s.
Conclusion: SAVF are created less frequently due to predominantly smaller vessel caliber. However, it can be a viable alternative site for fistula implantation. Vascular mapping is required to ensure that both vessels have minimum 2 mm caliber. Maturation in SAVF have comparable results with the other sites.
The effect of fractionated ethanol red ginger (Zingiber officinale var. rubrum) extract on the pH level of Streptococcus gordonii metabolism (In-vitro Laboratory Experimental Research)
Authors: Sinaredi Betadion Rizki , Wicaksono Dimas Prasetianto , Saskianti Tania , Ridwan Rini Devijanti , Luthfi Muhammad , Pratiwi Reinanda , Laosuwan Kittipong , Nuraini Prawati 
Published: March 2024

Introduction: Oral health is important for the quality of human life, so maintaining oral health is necessary. However, many people have dental caries as one of the main diseases in the oral cavity. Dental caries can occur due to pH falling in the oral cavity by acid-producing bacteria, such as Streptococcus gordonii, which metabolizes sucrose as an energy source and produces lactic acid. Then, the environmental pH decreases. Chemicals are widely used as antibacterial agents, but long-term use can cause negative effects, hence antibacterial agents with minimal side effects are needed. Red ginger is one of the options that appears as a promising antibacterial agent. Even though a lot of research has been investigated regarding red ginger, there is limited information on the effect of fractionated red ginger extract on pH in bacterial metabolism, especially Streptococcus gordonii. This study aims to analyze the effect of the other components in red ginger besides its essential oil on the pH level of Streptococcus gordonii metabolism.
Methods: The groups in this study are control group 1 (bacteria, BHIB), control 2 (bacteria, BHIB, 5% sucrose), and treatment groups (bacteria, BHIB, 5% sucrose, extract red ginger 1.56% and 0.78%). Data were analyzed with Duncan's One-Way ANOVA and Post-Hoc Multiple Comparison.
Results: The pH level of control group 2 was lower than group control 1 and treatment groups (p<0.05).
Conclusion: Fractionated ethanol extract of red ginger inhibits the decreasing pH level in the Streptococcus gordonii.
‘And in the Morning the Cook … Shall Go into his Kitchen’
Authors: Hayward Vicky 
Published: March 2024

This article contextualizes the approach taken by and publication of Juan Altamiras' recipe book, New Art of Cookery, Learned From The School of Economic Experience (1745). It considers the book as a surfacing of long-evolving and specifically Spanish Franciscan food philosophy and unpacks the mechanisms by which its influence spread through popular cookery. Viewed in such a long perspective and using different methodological approaches, one can follow spiritually rooted ideas carrying secular implications which, when detached from friary life and absorbed into a wider cultural arena, nurtured emerging popular Spanish gastronomy and influenced the wider development of ‘economic’ cookery.
Artificial Intelligence and Ethics
Authors: HILCENKO CHRISTINE , TAUBMAN-BASSIRIAN TARA 
Published: March 2024

A more covert aspect of Artificial Intelligence (AI) pertains to the ethical quandaries surrounding the actions of machines. In the case of Large Language Models (LLMs), hidden beneath their seemingly impeccable automated outputs lies a colossal amalgamation of trillions of compiled data points, comprising copied blogs, articles, essays, books, and artworks. This raises profound questions about copyright ownership and retribution for the original authors. But beyond intellectual property, another insidious facet of LLMs emerges – their propensity to cause harm to individuals through what can only be described as hallucinatory outputs. Victims of these AI- -generated delusions suffer defamation, and their plight remains largely unnoticed. Amidst the marvels of AI, the plight of the underpaid laborers who form the backbone of AI development is seldom acknowledged, a subject that warrants more profound discussion. Furthermore, as AI algorithms continue to permeate various aspects of society, they bring to the fore issues of bias. For instance, facial recognition technologies frequently exhibit skewed outcomes, leading to false accusations and grave consequences due to over-reliance on these technologies.
The algorithmic schemes employed in CV selection for job applications or university admissions also raise concerns about fairness.
The question of machines replacing the human workforce looms ever larger on the horizon. The potential socio-economic ramifications demand careful evaluation.
Lastly, the extensive reliance of artificial intelligence on vast datasets, including copyrighted works, results in the creation of gargantuan data servers with an unimaginable environmental impact.
The hidden aspects of artificial intelligence encompass a multitude of ethical dilemmas, spanning intellectual property rights, biases, labour conditions, societal impacts, and environmental considerations. A thorough and elaborate examination of these issues is essential to navigate the ever-evolving landscape of AI responsibly and ethically.
<i>GATA2 </i>mutant variant allele frequency may reflect prognosis in Chinese adult patients with de novo cytogenetically normal acute myeloid leukemia
Authors: Ren Huanying , Hong Minglin , Feng Jingyi , Hao Zhuanghui , Chen Xian , Liang Fengting , Wei Wei , Liang Xuelan , Wang Hongwei , Chen Xiuhua 
Published: March 2024

Exploration of variant allele frequency (VAF) of GATA2 mutations (GATA2mut) provides insights into acute myeloid leukemia (AML)prognosis. In this study, we analyzed GATA2mut and co-mutations in 166 Chinese patients with cytogenetically normal AML. This was done through targeted next-generation sequencing of 34 genes associated with myeloid leukemia. GATA2mut was identified in 17 (10%) patients being significantly correlated with co-mutations in CCAAT/enhancer-binding protein alpha (CEBPA) double mutation (P = 0.001). We observed that the N-terminal zinc finger domain (ZF1) was linked to CEBPA mutations, while the C-terminal zinc finger domain (ZF2) was associated with Wilms' tumor 1 (WT1) mutations. It was also noted that patients with GATA2mut had lower platelet counts at diagnosis (P = 0.032). In the entire cohort, GATA2mut had no significant prognostic impact on overall survival (OS) (P = 0.762) and relapse-free survival (RFS) (P = 0.369) compared to patients with GATA2wt. The OS (P = 0.737) and RFS (P = 0.894) of the ZF1 mutation were similar to those of the ZF2 mutation. Most patients with GATA2 mutations were classified in the ELN2022 favorable- and intermediate-risk groups. GATA2mut patients in the favorable-risk group were divided into GATA2High and GATA2Low groups using a median cutoff variant allele frequency (VAF) of 40.13%. GATA2High patients were associated with worse OS (P = 0.031) and RFS (P = 0.021) than GATA2Low patients. In the intermediate-risk group, the high median VAF of GATA2 (≥38.51%) had no significant effect in OS and RFS compared with the low median VAF (<38.51%). This study offers new insights on the prognosis of GATA2mut in the favorable-risk group, where VAF can be used as a guide.
The MAPH Score Predicts Coronary Slow Flow. A Retrospective Case-Controlled Study
Authors: Kaplangoray Mustafa , Toprak Kenan , Aydın Cihan , Cekici Yusuf , Yıldırım Arafat , Ozcan Abacıoglu Ozge 
Published: March 2024

Aim. The MAPH score is a new score that combines mean platelet volume (MPV), hematocrit, and total protein, which are markers of whole blood viscosity (WBV). We aimed to investigate the relationship between the MAPH score and the coronary slow flow phenomenon (CSF).Material and methods. A total of 201 patients were included in the study. 105 had CSF and 96 had normal coronary flow (NCF). Coronary flow was measured by the Thrombolysis in Myocardial Infarction frame count (TFC) method. The patients’ MPV, age, hematocrit, and total protein were recorded. High (HSR) and low shear rates (LSR) were calculated, based on total protein and hematocrit values. Cut-off values for CSF were determined using the Youden’s index, and the score was determined as 0 or 1 according to the cut-off values. The sum of these scores was the MAPH score.Results. The mean age of the patients included in the study was 51.1±7.9 (n=201, 54.2 % male). Hyperlipidemia, DM, and HT rates of both groups were similar, but the mean age of the CSF group was higher (p=0.773; p=0.549; p=0.848; p <0.001, respectively). Total protein, MPV, hematocrit, HSR and LSR were higher in the CSF group (p< 0.001, for all values). Comparative receiver operating characteristic (ROC) curve analysis showed that the performance of the MAPH score in predicting CSF is better than the performance of these parameters separately.Conclusion. A new score, the MAPH score, may be used to identify the presence of CSF.
Evaluation of the Relationship Between Vitamin D Deficiency and Subclinical Cardiac Dysfunction Using 2D/3D Strain Echocardiography in Healthy People
Authors: Gerede Uludag Demet Menekse , Aydogan Berna Imge , Tan Türkan Seda , Acıbuca Aynur , Turan Nazlı , Emral Rıfat , Dincer Irem , Erol Cetin 
Published: March 2024

Aim. Vitamin D deficiency has a high prevalence in the population and is highly associated with cardiovascular diseases. The aim of this study was to evaluate subclinical left ventricular (LV) function using strain analysis in healthy individuals with vitamin D deficiency.Material and methods. 113 healthy volunteers were enrolled in the study (age, 44.1±7 yrs, 34 male). All volunteers underwent two-dimensional (2D) and three-dimensional (3D) speckle tracking echocardiography after conventional echocardiographic evaluation. The subjects were divided into two groups according to their vitamin D concentrations. 61 subjects with vitamin D less than 20 ng / ml were included in the vitamin D deficiency group. The baseline clinical characteristics, laboratory measurements, echocardiographic data, including 2D and 3D global longitudinal strain (GLS) values, were compared between the groups.Results. The 2D GLS values of the subjects with vitamin D deficiency were lower (mathematically less negative) than subjects with normal vitamin D (–16.1±3.4 vs –19.3±4.2, p<0.001). Similarly, the 3D GLS results were lower in subjects with vitamin D deficiency (–18.3±5.2 vs –24.1±6.9, p<0.001). A significant correlation was detected between the vitamin D concentrations and the 2D and 3D GLS measurements. (r=0.765 and r=0.628, respectively, p<0.001). Vitamin D was found to be an independent predictor of impaired 2D and 3D LV GLS (p=0.031, p=0.023, respectively).Conclusion. Subclinical LV dysfunction in healthy individuals with vitamin D deficiency was demonstrated by 3D and 2D strain analysis. Due to potential negative effects of vitamin D deficiency on cardiac function, more attention should be paid to healthy individuals with vitamin D deficiency.
Penetapan Pengaruh Usefulness, Easy Of Use, Risk Terhadap Intention To Buy Online Melalui Customer Attitude Berbasis Media Sosial Di Bellaneshop
Authors: Marissa Inka , Wedhasmara Ari 
Published: March 2024

Penelitian ini dilakukan untuk mengetahui apakah perceived usefulness, perceived ease of use, perceived risk berpengaruh terhadap intention to buy online melalui consumer attitude berbasis media sosial di Bellaneshop. Penelitian ini merupakan penelitian kuantitatif. Teknik analisis yang digunakan dalam penelitian ini adalah Analisis Jalur. Hasil menunjukkan bahwa perceived usefulness memiliki pengaruh positif dan signifikan terhadap consumer attitude, perceived ease of use memiliki pengaruh positif dan signifikan terhadap consumer attitude, perceived risk memiliki pengaruh negatif dan signifikan terhadap consumer attitude¸ dan consumer attitude memiliki pengaruh positif dan signifikan terhadap intention to buy online. Sehingga consumer attitude adalah variabel yang harus ada antara perceived usefulness, perceived ease of use, perceived risk dan intention to buy online.
The Role of Honey in Reproductive Age Gynecological Diseases: An Overview of Clinical Trials
Authors: Norouzi Allahleh Korabi Masoumeh , Rezghi Maedeh 
Published: March 2024

Honey has been used since ancient times to treat various diseases such as gynecological diseases. The current study aims to investigate clinical trials related to the therapeutic effects of honey on women's diseases. Databases including Web of Science, Scopus, PubMed, Google scholar, and SID were investigated for clinical studies focusing on honey in gynecological diseases up to 31 June 2022. Eligibility was checked based on selection criteria. Twenty-five clinical trials met the inclusion criteria. Therapeutic properties of honey and its compounds as a systemic and/or local treatment on vulvovaginal candidiasis, cervicitis, dysmenorrhea, premenstrual syndrome, labor pain, episiotomy and cesarean wounds, nipple fissure, breast cancer and intrauterine insemination (IUI), with the mechanisms of action of antibacterial, antifungal, anti-inflammatory, wound healing, analgesic, antioxidant and anticancer activities have been proven. It was also found that phenolic compounds including flavonoids and phenolic acids are the main ones responsible for most of these therapeutic effects of honey. This study supports the healing properties of honey in gynecological diseases at reproductive age. Also, in the current studies, honey proved safe with minor adverse effects. Of course, to achieve definitive conclusions about the effectiveness and safety of honey, it is necessary to conduct more clinical trials with a larger sample size, appropriate intervention duration, and optimal doses in future studies.
Avances en la lista roja de las plantas de Colombia
Authors: Lopez-Gallego Cristina , Morales-Morales Paula A. , Castellanos-Castro Carolina , Salinas Nelson , Aguirre-Santoro Julián , Aponte Angélica , Betancur Julio , Díaz-Vasco Oswaldo , Diazgranados-Cadelo Mauricio , Higuera-Díaz Diego , Idárraga-Piedrahíta Álvaro , Vallejo-Mayo Leidy 
Published: March 2024

Completar la Lista Roja de las Plantas de Colombia es una de las metas principales de la Estrategia Nacional para la Conservación de Plantas (ENCP) y es crucial para la planificación de la conservación de la flora del país. La serie del Libro Rojo de Plantas de Colombia realizó la primera contribución importante a la Lista Roja nacional, y desde el 2014 un equipo de trabajo asociado a la ENCP y el Grupo de Especialistas de Plantas de Colombia (GEPC) de la UICN han coordinado esfuerzos para seguir avanzando en esta tarea. Al final del 2022 la Lista Roja de Plantas a nivel nacional alcanzó un 12 % de cobertura de las especies reportadas en el país y para el año 2025 esta cobertura alcanzará al menos un 25 %. Según las evaluaciones finalizadas hasta el momento, el 37 % de las plantas evaluadas se encuentran amenazadas, pero la cifra es del 48 % si se consideran solamente las especies endémicas. Aquí se presenta un análisis de los patrones taxonómicos, ecológicos y geográficos en el riesgo de extinción de las especies evaluadas hasta el momento y se discuten perspectivas para completar la Lista Roja de las Plantas de Colombia.
Twin Prime Conjecture Proof
Authors: Thompson Daniel 
Published: March 2024

Abstract
The Twin Prime conjecture first proposed by French mathematician Alphonse de Polignac in the year 1846 remains unproven until now. This paper sets out to prove the Twin Prime conjecture by creating a system of equations and finding both a y element of ℕ, (y ϵ ℕ) and a y element of k, (y ϵ k) to find the twin prime values and then two further values where each will differ by an exact amount. From this proof the method demonstrates that the elements of these phenomena prove that there will be an infinite number of twin primes that differ by two.
MSC: 11-xx