bluuebunny/crossref_metadata_2025_split huggingface dataset:
The subcommissural organ regulates brain development via secreted peptides
Authors: Zhang Tingting , Ai Daosheng , Wei Pingli , Xu Ying , Bi Zhanying , Ma Fengfei , Li Fengzhi , Chen Xing-jun , Zhang Zhaohuan , Zou Xiaoxiao , Guo Zongpei , Zhao Yue , Li Jun-Liszt , Ye Meng , Feng Ziyan , Zhang Xinshuang , Zheng Lijun , Yu Jie , Li Chunli , Tu Tianqi , Zeng Hongkui , Lei Jianfeng , Zhang Hongqi , Hong Tao , Zhang Li , Luo Benyan , Li Zhen , Xing Chao , Jia Chenxi , Li Lingjun , Sun Wenzhi , Ge Woo-ping 
Published: April 2024

AbstractThe subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related as amphioxus and humans, but its function is largely unknown. To explore its function, we compared transcriptomes of SCO and non-SCO brain regions and found three genes,Sspo,Car3, andSpdef, that are highly expressed in the SCO. Mouse strains expressing Cre recombinase from endogenous promoter/enhancer elements of these genes were used to genetically ablate SCO cells during embryonic development, resulting in severe hydrocephalus and defects in neuronal migration and development of neuronal axons and dendrites. Unbiased peptidomic analysis revealed enrichment of three SCO-derived peptides, namely thymosin beta 4, thymosin beta 10, and NP24, and their reintroduction into SCO-ablated brain ventricles substantially rescued developmental defects. Together, these data identify a critical role for the SCO in brain development.
Organizational justice, supervisor-provided resources and duty orientation: lessons from the mining sector
Authors: Ansong Abraham , Gnankob Robert Ipiin , Agyemang Isaac Opoku , Issau Kassimu , Okorley Edna Naa Amerley 
Published: April 2024

PurposeThe study analysed the influence of organizational justice on the duty orientation of employees in the mining sector of Ghana. Also, it examined the mediating role of supervisor-provided resources in the relationship between organizational justice and duty orientation.Design/methodology/approachThe study obtained data through a self-administered questionnaire from 291 employees of a mining firm. The data were analysed and interpreted in light of the hypotheses using the partial least squares structural equation modelling technique.FindingsThe findings revealed that organizational justice had a significant positive relationship with duty orientation and supervisor-provided resources. The results again established that supervisor-provided resources had a significant positive relationship with duty orientation. The study finally documented that supervisor-provided resources partially mediate the relationship between organizational justice and duty orientation.Practical implicationsWe recommended that the management of the mining companies devote resources to developing organizational justice policies based on fairness in resource allocation, clear roles, employee feedback and effective information dissemination. Furthermore, supervisors should place priority on acquiring and dispensing resources as employees demonstrate their willingness to improve duty orientation.Originality/valueThe study contributes to knowledge in a novel research area. It adds to empirical evidence by highlighting the possible variables that may influence employees to engage in duty orientation.
Breaking barriers: paving the path to sustainable fashion – insights for a greener apparel and textile sector
Authors: Vishwakarma Amit , Mehrotra Deepti , Agrahari Ritu , Kharub Manjeet , Gupta Sumit , Jagtap Sandeep 
Published: April 2024

PurposeThe apparel and textile sector poses a significant environmental challenge due to its substantial contribution to pollution in the form of air, water and soil pollution. To combat these issues, the adoption of sustainable practices is essential. This study aims to identify and analyse the barriers that hinder the progress of sustainability in the apparel and textile industry. By consulting experts in the field, critical barriers were identified and given special attention.Design/methodology/approachTo achieve the research objective, an integrated approach involving Interpretive Structural Modelling (ISM) and fuzzy MICMAC decision-making techniques was employed. The results were further validated through the Decision-Making Trial and Evaluation Laboratory (DEMATEL) method.FindingsThe findings highlight that barrier related to clothing disposal, inadequate adaptation to modern technology, challenges affecting sector efficiency and issues related to fashion design are crucial in influencing the remaining six barriers. Based on the outcomes of the DEMATEL method, a comprehensive cause-and-effect diagram was constructed to gain a deeper understanding of these challenges.Practical implicationsThis research provides valuable insights for policymakers and stakeholders in the apparel and textile industry. It offers a strategic framework to address and overcome sustainability barriers, promoting the development of a more environmentally responsible and resilient sector.Originality/valueThe purpose of this research is to conduct an in-depth investigation of the barriers apparel and textile sectors. It is feasible that both the management team and the medical experts who provide direct patient care could benefit from this research.
Impact of the COVID-19 pandemic on small and medium-sized enterprise (SME) government suppliers involved in government green procurement (GGP)
Authors: Masron Nurin Athilah , Zainol Zaini , Ismail Suhaiza 
Published: April 2024

PurposeThe objectives of this paper are twofold. First, it aims to investigate the impact of the COVID-19 pandemic on the activities and performance of small and medium-sized enterprises (SMEs) government suppliers involved in government green procurement (GGP). Second, it examines the differences in the impact of COVID-19 between small and medium-sized groups.Design/methodology/approachThe study used a questionnaire survey that was distributed to SMEs listed in the MyHIJAU directory that supply green goods and services to the government. Of the total 394 sample respondents, 126 usable questionnaires were received, representing a usable response rate of 31.98%. Descriptive analysis of mean score, standard deviation and mean score ranking was used to analyse the overall results. A t-test analysis was carried out to examine the differences between the small and medium-sized groups of companies.FindingsThe study discovers that the SME government suppliers involved in GGP were impacted by the COVID-19 pandemic. The top ranked impacts are that “the COVID-19 pandemic has heightened health and safety practices among the employees”, “the COVID-19 pandemic has reduced company’s turnover”, “the COVID-19 pandemic has forced the company to implement a cost reduction strategy”, “the COVID-19 pandemic has had a negative impact on the company’s ability to deliver work, supplies or services to the government” and “the COVID-19 pandemic has forced the company to incur higher production costs for green products or services provided”. However, there is no significant difference between the impact of the COVID-19 pandemic on the small and medium-sized group of enterprises.Originality/valueThe present study is among the fewer studies on the impact of the COVID-19 pandemic, with particular focus on SME government suppliers involved in GGP.
The impact of Industry 4.0 technologies on the resilience of established cross- border supply chains
Authors: Brookbanks Mike , Parry Glenn C. 
Published: April 2024

Purpose
This study aims to examine the effect of Industry 4.0 technology on resilience in established cross-border supply chain(s) (SC).

Design/methodology/approach
A literature review provides insight into the resilience capabilities of cross-border SC. The research uses a case study of operational international SC: the producers, importers, logistics companies and UK Government (UKG) departments. Semi-structured interviews determine the resilience capabilities and approaches of participants within cross-border SC and how implementing an Industry 4.0 Internet of Things (IoT) and capitals Distributed Ledger (blockchain) based technology platform changes SC resilience capabilities and approaches.

Findings
A blockchain-based platform introduces common assured data, reducing data duplication. When combined with IoT technology, the platform improves end-to-end SC visibility and information sharing. Industry 4.0 technology builds collaboration, trust, improved agility, adaptability and integration. It enables common resilience capabilities and approaches that reduce the de-coupling between government agencies and participants of cross-border SC.

Research limitations/implications
The case study presents challenges specific to UKG’s customs border operations; research needs to be repeated in different contexts to confirm findings are generalisable.

Practical implications
Operational SC and UKG customs and excise departments must align their resilience strategies to gain full advantage of Industry 4.0 technologies.

Originality/value
Case study research shows how Industry 4.0 technology reduces the de-coupling between the SC and UKG, enhancing common resilience capabilities within established cross-border operations. Improved information sharing and SC visibility provided by IoT and blockchain technologies support the development of resilience in established cross-border SC and enhance interactions with UKG at the customs border.
Likelihood ratios for changepoints in categorical event data with applications in digital forensics
Authors: Longjohn Rachel , Smyth Padhraic 
Published: April 2024

AbstractWe investigate likelihood ratio models motivated by digital forensics problems involving time‐stamped user‐generated event data from a device or account. Of specific interest are scenarios where the data may have been generated by a single individual (the device/account owner) or by two different individuals (the device/account owner and someone else), such as instances in which an account was hacked or a device was stolen before being associated with a crime. Existing likelihood ratio methods in this context require that a precise time is specified at which the device or account is purported to have changed hands (the changepoint)—this is the known changepoint likelihood ratio model. In this paper, we develop a likelihood ratio model that instead accommodates uncertainty in the changepoint using Bayesian techniques, that is, an unknown changepoint likelihood ratio model. We show that the likelihood ratio in this case can be calculated in closed form as an expression that is straightforward to compute. In experiments with simulated changepoints using real‐world data sets, the results demonstrate that the unknown changepoint model attains comparable performance to the known changepoint model that uses a perfectly specified changepoint, and considerably outperforms the known changepoint model that uses a misspecified changepoint, illustrating the benefit of capturing uncertainty in the changepoint.
Rapid on‐ground assessment after the 2019–2020 megafires reveals new information on rare and threatened plants in northern New South Wales, Australia
Authors: Saunders Manu E. , Andrew Rose L. , Mitchell‐Williams James , Pemberton Peter , Wandrag Elizabeth M. , Hunter John T. 
Published: April 2024

AbstractLack of ecological knowledge is a major challenge for effective conservation of threatened plant species in Australia as disturbance events, such as wildfire, increase in frequency and magnitude. Rapid on‐ground surveys are increasingly important to inform recovery strategies for rare and threatened plants in response to extreme wildfire events, yet resources are rarely available to deploy time‐sensitive surveys. Here, we utilize a rapid on‐ground survey and monitoring program to document basic biological and ecological information for 21 rare and threatened plant species from the New England bioregion in northern New South Wales, which were affected by the catastrophic 2019–2020 megafires. Our results fill an important knowledge gap of ecology, population size, distribution and response to fire for these taxa, document for the first time a species distribution pattern within the Torrington State Conservation Area and reveal previously undocumented plant–insect interactions for nine species, including likely pollination of Persoonia terminalis ssp. terminalis and Monotaxis macrophylla by native bee (Hymenoptera) and fly (Diptera) species. Our findings reveal that two species (Cassinia heleniae and Hakea macrorrhyncha) have scarce distribution and low population sizes, despite neither having a conservation listing and their threat status should be urgently assessed. Simple rapid on‐ground surveys can be more cost effective for delivering long‐term conservation outcomes for rare and threatened taxa and we advocate that future funding and prioritisation processes must support the immediate delivery of such surveys in response to disturbance events.
Evidence of drastic loss of dung beetle diversity after 25 years in an introduced Brazilian pasture
Authors: Correa César M. A. , Salomão Renato Portela , Abot Alfredo Raúl , Puker Anderson , Vaz‐De‐Mello Fernando Z. 
Published: April 2024

AbstractIn tropical forest ecosystems, pastures are considered a limiting environment for dung beetles, with long‐term negative effects on the diversity of this group. To understand how dung beetle diversity changes over time in introduced Brazilian pastures, studies comparing different periods are needed. Here, we conducted a study sampling dung beetles during 48 consecutive weeks in 1995 and 2020–2021. We used pitfall traps baited with fresh cattle dung in the same introduced pasture located in the Cerrado‐Pantanal ecotone of Brazil. Our study found that the total species richness of dung beetles decreased by 40% in 2020–2021 compared to 1995, which could negatively impact the ecological functions of the pastures. Given the importance of dung beetles for maintaining and functioning of pastures, the decline in dung beetle diversity could lead to the degradation of pasture landscapes. We advocate for management plans for livestock production in introduced pastures that include the long‐term conservation of dung beetle biodiversity. These plans will ensure the continued provision of dung beetle ecological services by dung beetles over the years.
Therapy‐related acute lymphoblastic leukaemia in women with antecedent breast cancer
Authors: Pourhassan Hoda , Zhang Jianying , Tinajero Jose , Pullarkat Vinod , Agrawal Vaibhav , Koller Paul , Al Malki Monzr , Aribi Ahmed , Salhotra Amandeep , Sandhu Karamjeet , Ali Haris , Stein Anthony , Marcucci Guido , Forman Stephen , Aldoss Ibrahim 
Published: April 2024

SummaryTherapy‐related acute lymphoblastic leukaemia (tr‐ALL) is a disease entity attributed to previous exposure to chemotherapy and/or radiation for antecedent malignancy. There is observed female predominance for tr‐ALL, likely due to high prevalence and excellent curable rate for non‐metastatic breast cancer as well as the frequent use of carcinogenic agents as part of adjuvant therapy. Here, we reviewed 37 women with diagnosis of ALL following breast cancer treatment with focus on cytogenetic categorization. Philadelphia chromosome positivity (Ph+), KMT2A alterations and other cytogenetic change groups were observed in 32%, 22% and 46% of patients respectively. Median overall survival (OS) and relapse‐free survival (RFS) were 19.4 and 12.9 months, overall while both OS and RFS were superior in tr‐ALL with Ph+ disease compared to KMT2Ar and other cytogenetics respectively. Seventeen (45.9%) patients underwent consolidative allogeneic haematopoietic cell transplantation (alloHCT) in CR1 out of which 4 (24%) relapsed following transplant. Both OS and RFS were superior in the KMT2Ar cytogenetics group following alloHCT. Ph chromosome represents the largest genetic entity of tr‐ALL following breast cancer therapy, and it may be associated with superior survival outcomes while KMT2Ar may be associated with poorer outcomes that can perhaps be mitigated by alloHSCT.
The fourth slope: A fundamental new classification of continental margins
Authors: Anell Ingrid 
Published: April 2024

AbstractContinental margins develop long submarine slopes, linking the shallow shelves along the continental landmasses to the deep abyssal plain. They are the results of a complex interaction between destructive and constructive processes, although by and large they are sites of deposition. There is a great amount of variation between the length, height, smoothness, gradient and variation thereof between the slope profiles; however, there is also recurring similarity in their shape. The similitude has suggested systematic relationships between the shape and the processes forming them, and led to studies on geomorphological categorisation based on curvatures. The potential for prediction of along‐strike variations and connection between morphology and sedimentary process is herein approached through broadening the mathematical functions used, detailed measurement, observation and curve‐fitting of over 150 passive continental margins. Previously, three functions have been used to categorise submarine slopes. The present study finds that four mathematical functions closely match the slopes: Linear, Gaussian, exponential and quadratic (positive and negative/inverse), and reveals that the fourth slope, the quadratic, is by far the most common. While exponential and quadratic slopes are similar there is a crucial difference in the way in which the angle of the slope changes. This study suggests that quadratic slopes represent systematically decreasing sediment deposition with distance, previously attributed to exponential slopes. Exponential slopes meanwhile, represent slope readjustment profiles with upper sediment bypass and lower slope aggradation. Linear slopes, which form the longest low‐angle slopes, form in response to high sediment input. Abrupt shelf‐edges form in shallower water and develop longer slope aprons, suggesting formation from erosional processes. This implies that the quintessential sigmoidal (s‐shaped, Gaussian function) slope, with a smooth rollover, represents the fundamental depositional slope profile.
Shifting the landscape: Dominant C‐terminal rare missense FOXL2 variants in non‐syndromic primary ovarian failure etiology
Authors: Jordan Pénélope , Verebi Camille , Hervé Bérénice , Perol Sandrine , Chakhtoura Zeina , Courtillot Carine , Bachelot Anne , Karila Daphné , Renard Céline , Grouthier Virginie , de la Croix Stanislas Mulot , Bernard Valérie , Fouveaut Corinne , de la Perrière Aude Brac , Jonard‐Catteau Sophie , Touraine Philippe , Plu‐Bureau Geneviève , Dupont Jean Michel , Christin‐Maitre Sophie , Bienvenu Thierry 
Published: April 2024

AbstractPathogenic germline variants in the FOXL2 gene are associated with Blepharophimosis, Ptosis, and Epicanthus Inversus syndrome (BPES) in humans, an autosomal dominant condition. Two forms of BPES have emerged: (i) type I (BPES‐I), characterized by ocular signs and primary ovarian failure (POI), and (ii) type II (BPES‐II) with no systemic associations. This study aimed to compare the distribution of FOXL2 variants in idiopathic POI/DOR (diminished ovarian reserve) and both types of BPES, and to determine the involvement of FOXL2 in non‐syndromic forms of POI/DOR. We studied the whole coding region of the FOXL2 gene using next‐generation sequencing in 1282 patients with non‐syndromic POI/DOR. Each identified FOXL2 variant was compared to its frequency in the general population, considering ethnicity. Screening of the entire coding region of the FOXL2 gene allowed us to identify 10 different variants, including nine missense variants. Of the patients with POI/DOR, 14 (1%) carried a FOXL2 variant. Significantly, six out of nine missense variants (67%) were overrepresented in our POI/DOR cohort compared to the general or specific ethnic subgroups. Our findings strongly suggest that five rare missense variants, mainly located in the C‐terminal region of FOXL2 are high‐risk factors for non‐syndromic POI/DOR, though FOXL2 gene implication accounts for approximately 0.54% of non‐syndromic POI/DOR cases. These results support the implementation of routine genetic screening for patients with POI/DOR in clinical settings.
Pharmacokinetics, pharmacodynamics, and safety of frunexian in healthy Chinese volunteer adults: A randomized dose‐escalation phase I study
Authors: Zhang Jia‐yu , Ruan Zou‐rong , Jiang Bo , Yang Dan‐dan , Wang Jia‐ying , Hu Yin , Wang Yong‐rui , Wang Yan‐mei , Lin Yun‐fei , Wang Ling‐ling , Lou Hong‐gang 
Published: April 2024

AbstractThe purpose of this study was to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of frunexian (formerly known as EP‐7041 and HSK36273) injection, a small molecule inhibitor of activated coagulation factor XI (FXIa), in healthy Chinese adult volunteers. This study was a randomized, placebo‐ and positive‐controlled, sequential, ascending‐dose (0.3/0.6/1.0/1.5/2.25 mg/kg/h) study of 5‐day continuous intravenous infusions of frunexian. Frunexian administration exhibited an acceptable safety profile with no bleeding events. Steady state was rapidly reached with a median time ranging from 1.02 to 1.50 h. The mean half‐life ranged from 1.15 to 1.43 h. Frunexian plasma concentration at a steady state and area under the concentration–time curve exhibited dose‐proportional increases. The dose‐escalation study of frunexian demonstrated its progressively enhanced capacities to prolong activated partial thromboplastin time (aPTT) and inhibit FXIa activity. The correlations between PK and PD biomarkers (aPTT/baseline and FXI clotting activity/baseline) were described by the two Emax models, with the EC50 values of 8940 and 1300 ng/mL, respectively. Frunexian exhibits good safety and PK/PD properties, suggesting it is a promising candidate for anticoagulant drug.