bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting the Probability of Tumor-Specific Survival in Patients Diagnosed With Primary Tumors in the Spinal Cord Using Nomogram Models
Authors: Huang Chao , Tang Tingting , Ding Zichuan , Wang Haoyang , Zhou Zongke 
Published: February 2024

Study Design A retrospective cohort study. Objective The goal of this study was to develop a useful clinical prediction nomogram to accurately predict the cancer-specific survival (CSS) of patients with primary spinal cord tumor (SCT), thereby formulating scientific prevention and aiding clinical decision-making. Methods In this study, patients with SCT diagnoses from the surveillance, epidemiology, and end results (SEER) database (2000-2018) were taken into account. Initially, a nomogram was created using the CSS-associated independent factors that were determined from both univariate and multivariable Cox regression analyses. Furthermore, the nomogram’s capacity for calibration, ability to discriminate, and actual clinical effectiveness were assessed through calibration curves, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA), respectively. Finally, a strategy for categorizing SCT patients’ risk was developed. Results This study included 909 SCT individuals. A novel nomogram was developed to forecast SCT patients’ CSS, taking into account age, histological type, tumor grade, tumor stage, and radiotherapy. These factors were identified as independent prognostic indicators for CSS in SCT patients. Elderly SCT patients with distant metastasis, advanced tumor grade, received radiotherapy, and confirmed lymphoma have a poor prognosis. Meanwhile, the risk classification system could differentiate SCT patients and realize targeted management. Conclusions The developed nomogram has the ability to accurately forecast the CSS in SCT individuals, aiding in precise decision-making during clinical practice, enhancing health planning, maximizing treatment advantages, and ultimately improving patient prognosis.
Outcomes and Return to Sport After Knee Osteochondral Allograft Transplant in Professional Athletes
Authors: Allahabadi Sachin , Quigley Ryan , Frazier Landon , Joyce Kaitlyn , Cole Brian J. 
Published: February 2024

Background: Limited data are available on the outcomes and return-to-sport rates after osteochondral allograft transplant in professional athletes. Purpose: To evaluate the experience of a single senior surgeon in treating professional athletes with osteochondral allograft transplant, including analyzing clinical outcomes and return to sport. Study Design: Case series; Level of evidence, 4. Methods: The authors performed a retrospective review of professional athletes treated with primary osteochondral allograft to the knee between January 1, 2001, and January 1, 2021, by a single surgeon. Athletes were required to play at the professional level in their sport and have a minimum of 2 years of follow-up. Return-to-sport rates and timing were evaluated. Patient-reported outcomes were assessed preoperatively and at final follow-up. Reoperations and failures were also tabulated. Results: The study included 15 professional athletes who represented a variety of sports, with follow-up at a mean of 4.91 ± 2.2 years (range, 2.0-9.4 years). The majority (8 athletes; 53%) had undergone prior surgeries to the operative knee. Eleven (73%) returned to sport at a mean of 1.22 ± 0.4 years (range, 0.75-2 years), and of the 8 undergoing isolated osteochondral allograft, 7 (87.5%) returned at 1.28 ± 0.3 years. Ten athletes (66.7% of total; 90.9% of those who returned) returned to sport at the same level or higher compared with before surgery. Significant improvements were seen in each assessed patient-reported outcome score at final follow-up. Two of the 3 (66.7%) patients who underwent concomitant meniscal allograft transplant were able to return to sport at the same level or higher than presurgery. Three (20%) underwent second-look arthroscopy, 1 (6.7%) of whom underwent cartilage debridement of the osteochondral allograft. Conclusion: Osteochondral allograft transplant in professional athletes can result in a high rate of return to play at a similar or higher level as presurgery, even when performed with concomitant procedures such as meniscal allograft transplant. High-level athletes should expect significant postoperative improvement in clinical outcomes.
Comparison of Foot Kinematics Between Normal Arch and Flexible Flatfoot Using the Oxford Foot Model: A Matched Case-Control Study
Authors: Vijittrakarnrung Chaiyanun , Mongkolpichayaruk Atipong , Limroongreungrat Weerawat , Chuckpaiwong Bavornrit 
Published: February 2024

Background: Symptomatic flexible flatfoot causes alterations in gait, but exactly how this condition affects the intersegmental motion of the foot during the gait cycle remains unclear. Previous studies have examined the kinematics, yielding inconsistent findings. Therefore, the objective of this study was to investigate how flexible flatfoot deformity, defined as Johnson and Strom classification staging II, affects the intersegmental motion of the foot during fast walking based on a comparison with the matched control group. Methods: Eleven participants with symptomatic flexible flatfoot and 11 healthy matched control participants were recruited using a foot screening protocol incorporated through a foot physical examinations and radiographic measurements. All demographic characteristics exhibited comparable profiles between the groups. During controlled walking, kinematic outcomes pertaining to the hallux, hindfoot, forefoot, and tibia were collected using the multisegmental Oxford Foot Model. Results: All spatiotemporal parameters were comparable between the groups. In comparison to the control group, individuals with symptomatic flexible flatfoot demonstrated increased hallux valgus and plantarflexion, increased forefoot abduction, heightened hindfoot eversion, and internal rotation. Notably, no significant major differences were observed in the tibia motion segment. Further, significant correlations were identified between static foot measurements and the extent of the maximum deviation observed during dynamic kinematic assessments. Conclusion: Compared with age- and gender-matched controls, participants with symptomatic flexible flatfoot exhibited significant gait pattern deviations. A significant correlation also exists between static foot deformity measurements and dynamic kinematic deviations. Collectively, these findings have implications for developing targeted therapeutic interventions to address flexible flatfoot. Level of evidence: Level III, diagnostic study.
Analysing India’s Export Competitiveness in ASEAN Economies: Insights from Viner’s Trade Creation Model
Authors: Dawani Chandni , Pareek Deepa 
Published: February 2024

Both India and ASEAN are characterised by dynamic market economies and have implemented extensive reforms to deepen their economic integration. Despite the existing economic links between them, this article acknowledges that the trade relations are significant but fall short of their full potential. In this context, the present study utilises a modified trade creation approach to estimate India’s export potential at the sectoral level with individual ASEAN member states for the years 2010 and 2021. The analysis has identified five most significant trading partners in the region, namely, Singapore, Thailand, Malaysia, Vietnam, Indonesia, which together represent substantial trading opportunities in the five broad sectors such as Machinery, Chemical products, Base metals, Plastics, Minerals. Additionally, this article explores ASEAN’s GVC linkages with India vis-à-vis world at an aggregate and sectoral level over the last decade. We base our analysis on the P&C using the UN Broad Economic Category (BEC) product classification, concorded with HS trade classification. The findings reveal a marginal decline in the region’s share of GVC trade with India relative to its global GVC trade. JEL Classification: F10, F14, F15
Enricofrancoite, KNaCaSi4O10, a new Ca–K–Na silicate from Somma–Vesuvius volcano, southern Italy
Authors: Balassone Giuseppina , Panikorovskii Taras L. , Pellino Annamaria , Bazai Ayya V. , Bocharov Vladimir N. , Goychuk Olga F. , Avdontseva Evgenia Yu. , Yakovenchuk Victor N. , Krivovichev Sergey V. , Petti Carmela , Cappelletti Piergiulio , Mondillo Nicola , Moliterni Anna , Altomare Angela , Izzo Francesco 
Published: February 2024

AbstractEnricofrancoite (IMA2023–002), ideally KNaCaSi4O10, is a new litidionite-group member found as the product of high-temperature alteration of hosting silicates with the enrichment by Cu-bearing fluids at the rock–fumaroles interface related to the 1872 eruption of Somma–Vesuvius volcano, southern Italy. It occurs as euhedral and platy crystals or crusts together with litidionite, tridymite, wollastonite and Al- and Fe-bearing diopside, kamenevite, perovskite, rutile, Ti-rich magnetite and colourless Si-glass. Single crystals of enricofrancoite are transparent colourless or light blue with a vitreous lustre. Mohs hardness is 5.5. Dmeas is 2.63(3) g/cm3 and Dcalc is 2.63 g/cm3. The mineral is optically biaxial (−), α = 1.542(5), β = 1.567(5),γ = 1.575(5); 2V(meas) = 60(2)° and 2Vcalc = 58°. The mean chemical composition (wt.%, electron-microprobe data) is: SiO2 64.81, Al2O3 0.03, TiO2 0.08, FeO 0.07, MgO 1.71, CaO 10.64, CuO 2.22, Na2O 8.56, K2O 11.41, total 99.94. The empirical formula based on 10 O apfu is: K0.90Na1.03(Ca0.71Mg0.16Cu0.10)Σ0.97Si4.02O10. The Raman spectrum contains bands at 133, 248, 265, 290, 335, 400, 438, 510, 600, 690 and 1120 cm–1 and the wavenumbers of the IR absorption bands are: 424, 470, 492, 530, 600, 630, 690, 750, 788, 970, 1040 and 1160 cm–1. The eight strongest lines of the powder X-ray diffraction pattern are [d, Å (I, %) hkl]: 6.75 (42) 01$\bar{1}$, 3.65 (20) 11$\bar{2}$, 3.370 (100) 02$\bar{2}$, 3.210 (52) 102, 3.051 (18) 111, 3.033 (25) 2$\bar{1}\bar{2}$, 2.834 (22) 02$\bar{3}$ and 2.411 (72) 03$\bar{2}$. Enricofrancoite is triclinic, space group P$\bar{1}$, unit-cell parameters refined from the single-crystal data are a = 7.0155(4) Å, b = 8.0721(4) Å, c = 10.0275(4) Å, α = 104.420(4)°, β = 99.764(4)°, γ = 115.126(5)° and V = 472.74(5) Å3. The crystal structure has been refined from single-crystal X-ray diffraction data to R1 = 0.035 on the basis of 2078 independent reflections with Fo > 4σ(Fo). Enricofrancoite is an H2O-free analogue of calcinaksite with 5-coordinated Ca2+ at the M site.
ST-LaneNet: Lane Line Detection Method Based on Swin Transformer and LaneNet
Authors: Du Yufeng , Zhang Rongyun , Shi Peicheng , Zhao Linfeng , Zhang Bin , Liu Yaming 
Published: February 2024

AbstractThe advancement of autonomous driving heavily relies on the ability to accurate lane lines detection. As deep learning and computer vision technologies evolve, a variety of deep learning-based methods for lane line detection have been proposed by researchers in the field. However, owing to the simple appearance of lane lines and the lack of distinctive features, it is easy for other objects with similar local appearances to interfere with the process of detecting lane lines. The precision of lane line detection is limited by the unpredictable quantity and diversity of lane lines. To address the aforementioned challenges, we propose a novel deep learning approach for lane line detection. This method leverages the Swin Transformer in conjunction with LaneNet (called ST-LaneNet). The experience results showed that the true positive detection rate can reach 97.53% for easy lanes and 96.83% for difficult lanes (such as scenes with severe occlusion and extreme lighting conditions), which can better accomplish the objective of detecting lane lines. In 1000 detection samples, the average detection accuracy can reach 97.83%, the average inference time per image can reach 17.8 ms, and the average number of frames per second can reach 64.8 Hz. The programming scripts and associated models for this project can be accessed openly at the following GitHub repository: https://github.com/Duane711/Lane-line-detection-ST-LaneNet.
Aluminum enhances the oxidative damage of ZnO NMs in the human neuroblastoma SH-SY5Y cell line
Authors: Jimenez-Chavez Arturo , Pedroza-Herrera Gladis , Betancourt-Reyes Israel , De Vizcaya Ruiz Andrea , Masuoka-Ito David , Zapien Juan Antonio , Medina-Ramirez Iliana E. 
Published: February 2024

AbstractBare and doped zinc oxide nanomaterials (ZnO NMs) are of great interest as multifunctional platforms for biomedical applications. In this study, we systematically investigate the physicochemical properties of Aluminum doped ZnO (AZO) and its bio-interactions with neuroblastoma (SH-SY5Y) and red blood (RBCs) cells. We provide a comprehensive chemical and structural characterization of the NMs. We also evaluated the biocompatibility of AZO NMs using traditional toxicity assays and advanced microscopy techniques. The toxicity of AZO NMs towards SH-SY5Y cells, decreases as a function of Al doping but is higher than the toxicity of ZnO NMs. Our results show that N-acetyl cysteine protects SH-SY5Y cells against reactive oxygen species toxicity induced by AZO NMs. ZnO and AZO NMs do not exert hemolysis in human RBCs at the doses that cause toxicity (IC50) in neuroblastoma cells. The Atomic force microscopy qualitative analysis of the interaction of SH-SY5Y cells with AZO NMs shows evidence that the affinity of the materials with the cells results in morphology changes and diminished interactions between neighboring cells. The holotomographic microscopy analysis demonstrates NMs' internalization in SH-SY5Y cells, changes in their chemical composition, and the role of lipid droplets in the clearance of toxicants.
Graphical Abstract
Safety and effcacy of remimazolam tosilate for sedation during combined spinal-epidural anesthesia for orthopedic procedures: a randomized controlled trial
Authors: Chen Yufei , Cai Yimeng , Yu Guoqing , Zhang Xi , Hu Tian , Xue Rui 
Published: February 2024

Abstract
Objective
The objective of this study was to assess the efficacy and safety of Remimazolam in the context of combined spinal-epidural anesthesia for sedation during orthopedic surgery.

Methods
This randomized controlled trial enrolled patients scheduled for orthopedic surgery under combined spinal-epidural anesthesia (N = 80), who were randomly allocated to receive either dexmedetomidine (Group-D) or remimazolam (Group-R). The target sedation range aimed for a Ramsay score of 2–5 or a BIS value of 60–80 to evaluate the effectiveness and safety of remimazolam during sedation.

Results
The time taken to achieve the desired level of sedation was significantly shorter in the remimazolam group compared to the dexmedetomidine group (3.69 ± 0.75 vs. 9.59 ± 1.03; P < 0.0001). Patients in the remimazolam group exhibited quicker recovery, fewer intraoperative adverse events, more consistent vital signs, and greater satisfaction at various time points throughout the surgery.

Conclusion
This preliminary study demonstrates that remimazolam tosilate serves as a safe and effective sedative for orthopedic surgery performed under combined spinal-epidural anesthesia, in comparison with dexmedetomidine.
Macronutrients quality indices and risk of metabolic syndrome and its components in Iranian adults
Authors: Farhadnejad Hossein , Mokhtari Ebrahim , Teymoori Farshad , Jahromi Mitra Kazemi , Saber Niloufar , Ahmadirad Hamid , Norouzzadeh Mostafa , Mirmiran Parvin , Azizi Fereidoun 
Published: February 2024

Abstract
Background/aim
Evidence from recent studies suggested that the quality of dietary macronutrients can play a possible role in predicting the risk of metabolic disorders. In the current study, we aimed to assess the association of carbohydrate quality index (CQI) and protein score with the risk of metabolic syndrome (MetS) in Iranian adults.

Methods
This prospective study was conducted within the framework of the Tehran Lipid and Glucose Study on 1738 individuals aged between 40 and 70 years old, who were followed up for a mean of 6.1 years. A food frequency questionnaire was used to determine CQI and protein scores. The multivariable adjusted Cox regression model was used to calculate the hazard ratio (HR) of MetS across quartiles of protein score and CQI, and its components.

Results
The mean ± standard deviation (SD) age and body mass index of the study population (42.5% men) were 49.3 ± 7.5 years and 27.0 ± 4.0 kg/m2, respectively. Mean ± SD scores of CQI and protein for all participants were 12.6 ± 2.4 and 10.3 ± 3.5, respectively. During the study follow-up, 834(48.0%) new cases of MetS were ascertained. In the multivariable-adjusted model, the risk of MetS was decreased across quartiles of CQI (HR = 0.83;95%CI:0.69–1.00, Ptrend=0.025) and protein score (HR = 0.75; 95% CI:0.60–0.94, Ptrend=0.041). Also, Of CQI components, the whole grain/total grains ratio showed a significant inverse association with the risk of MetS (HR = 0.75;95%CI:0.60–0.94, Ptrend=0.012).

Conclusion
Our findings revealed that a dietary pattern with higher CQI and protein score may be related to a reduced risk of MetS in adults.
Association between the trajectory of ideal cardiovascular health metrics and incident chronic kidney disease among 27,635 older adults in northern China–a prospective cohort study
Authors: Bai Pufei , Shao Xian , Ning Xiaoqun , Jiang Xi , Liu Hongyan , Lin Yao , Hou Fang , Zhang Yourui , Zhou Saijun , Yu Pei 
Published: February 2024

Abstract
Background
There is a lack of relevant studies evaluating the long-term impact of cardiovascular health factor (CVH) metrics on chronic kidney disease (CKD).

Objective
This study investigates the long-term change in CVH metrics in older people and explores the relationship between CVH metrics trajectory and CKD.

Methods
In total, 27,635 older people aged over 60 from the community-based Tianjin Chronic Kidney Disease Cohort study were enrolled. The participants completed five annual physical examinations between January 01, 2014, and December 31, 2018, and a subsequent follow-up between January 01, 2019, and December 31, 2021. CVH metrics trajectories were established by the group-based trajectory model to predict CKD risk. The relationships between baseline CVH, CVH change (ΔCVH), and CKD risk were also explored by logistic regression and restricted cubic spline regression model. In addition, likelihood ratio tests were used to compare the goodness of fit of the different models.

Results
Six distinct CVH metrics trajectories were identified among the participants: low-stable (11.19%), low-medium-stable (30.58%), medium-stable (30.54%), medium-high-decreased (5.46%), medium-high-stable (18.93%), and high-stable (3.25%). After adjustment for potential confounders, higher CVH metrics trajectory was associated with decreased risk of CKD (P for trend < 0.001). Comparing the high-stable with the low-stable group, the risk of CKD decreased by 46%. All sensitivity analyses, including adjusting for baseline CVH and removing each CVH component from the total CVH, produced consistent results. Furthermore, the likelihood ratio test revealed that the model established by the CVH trajectory fit better than the baseline CVH and Δ CVH.

Conclusion
The higher CVH metrics trajectory and improvement of CVH metrics were associated with decreased risk of CKD. This study emphasized the importance of improving CVH to achieve primary prevention of CKD in older people.
How might secondary dementia prevention programs work in practice: a pre-implementation study of the APPLE-Tree program
Authors: Morse Rachel M. , Lang Iain , Rapaport Penny , Poppe Michaela , Morgan-Trimmer Sarah , Cooper Claudia 
Published: February 2024

Abstract
Background
Over 850,000 people in the UK currently have dementia, and that number is expected to grow rapidly. One approach that may help slow or prevent this growth is personalized dementia prevention. For most people, this will involve targeted lifestyle changes. These approaches have shown promise in trials, but as of yet, the evidence for how to scale them to a population level is lacking. In this pre-implementation study, we aimed to explore stakeholder perspectives on developing system-readiness for dementia prevention programs. We focused on the APPLE-Tree program, one of several low-intensity, lifestyle-based dementia prevention interventions currently in clinical trials.

Methods
We conducted semi-structured interviews with health and social care professionals without previous experience with the APPLE-Tree program, who had direct care or managerial experience in services for older adults with memory concerns, without a dementia diagnosis. We used the Consolidated Framework for Implementation Research to guide interviews and thematic analysis.

Results
We interviewed 26 stakeholders: commissioners and service managers (n = 15) and frontline workers (n = 11) from eight NHS and 11 third sector organizations throughout England. We identified three main themes: (1) favorable beliefs in the effectiveness of dementia prevention programs in enhancing cognition and wellbeing and their potential to fill a service gap for people with memory concerns, (2) challenges related to funding and capacity to deliver such programs at organizations without staff capacity or higher prioritization of dementia services, and (3) modifications to delivery and guidance required for compatibility with organizations and patients.

Conclusion
This study highlights likely challenges in scale-up if we are to make personalized dementia prevention widely available. This will only be possible with increased funding of dementia prevention activities; integrated care systems, with their focus on prevention, may enable this. Scale-up of dementia prevention programs will also require clear outlines of their core and adaptable components to fit funding, patient, and facilitator needs.
Cognitive frailty and its association with disability among Chinese community-dwelling older adults: a cross-sectional study
Authors: Kong Ling-lin , Xie Wen , Dong Zi-yan , Liu Yue-ting , Zhao Hui-Min , Fan Jun-Yao , Qi Xiao-jing , Li Jie 
Published: February 2024

Abstract
Background
There are a variety of determinants that are key to functional disability of older adults. However, little is known regarding the relationship between cognitive frailty and disability among older people. The aims of this study were to examine the associations between cognitive frailty and its six components with instrumental activities of daily living (IADL) functioning in community-dwelling older adults.

Methods
A total of 313 community-dwelling older adults (aged ≥ 65 years) were recruited from eight community centers in central China. Cognitive frailty was operationalized using the Mini-Mental State Examination for the evaluation of cognitive status and the Fried criteria for the evaluation of physical frailty. The outcome was functional disability assessed by the IADL scale. The association between cognitive frailty, as well as its components, and IADL limitations was identified by conducting binary logistic regression analysis.

Results
The prevalence of cognitive frailty was 8.9% in this study. The results showed that cognitive frailty (OR = 22.86) and frailty without cognitive impairment (OR = 8.15) were associated with IADL limitations. Subdimensions of cognitive frailty, exhaustion, weakness, low physical activity and cognitive impairment components were independently associated with IADL limitations.

Conclusion
Cognitive frailty was associated with a higher prevalence of disability. Interventions for improving cognitive frailty should be developed to prevent IADL disability among community-dwelling older adults in China.