bluuebunny/crossref_metadata_2025_split huggingface dataset:
When Knowing Grammar Depends on Knowing Vocabulary: Native-Speaker Grammaticality Judgements of Sentences with Real and Unreal Words
Authors: Barcroft Joe 
Published: May 2007

Abstract: This study examined how the presence of real versus unreal words in sentences affected the ability of native English speakers to make accurate grammaticality judgements and forced-choice decisions for sentences with violations in the use of dative alternation and comparatives. Sentences with dative alternation violations contained polysyllabic verbs (*John explained Mary the plan) that were real (e.g., explained), similar (e.g., explunned), and dissimilar (e.g., tidnopped) to real verbs. Sentences with comparative violations contained polysyllabic adjectives (*Robert is demandinger than Allen) that were real (e.g., demanding), similar (e.g., demunding), and dissimilar (e.g., natormunt) to real adjectives. Accuracy of grammaticality judgements was much lower for sentences with unreal words than real words. For sentences with comparatives, accuracy also was higher in sentences with similar words than with dissimilar words, demonstrating a graded effect for partial access. These findings provide support for theoretical accounts that associate knowledge of these structures with knowledge of real words and for instruction oriented toward the development of vocabulary knowledge.
Perceived Economic Burden, Mortality, and Health Status in Patients With Heart Failure
Authors: Yu Yuan , Liu Jiamin , Zhang Lihua , Ji Runqing , Su Xiaoming , Gao Zhiping , Xia Shuang , Li Jing , Li Liwen 
Published: March 2024

ImportanceIn the face of an emerging heart failure (HF) epidemic, describing the association between perceived economic burden (PEB) and health care outcomes is an important step toward more equitable and achievable care.ObjectivesTo examine the association between PEB and risk of 1-year clinical outcomes and HF–specific health status in patients with acute decompensated HF.Design, Setting, and ParticipantsThis prospective, multicenter, hospital-based cohort study prospectively enrolled adult patients hospitalized for acute decompensated HF at 52 hospitals in China from August 2016 to May 2018, with 1-year follow-up. Data were analyzed on June 17, 2022.ExposurePerceived economic burden, categorized as severe (cannot undertake expenses), moderate (can almost undertake expenses), or little (can easily undertake expenses).Main Outcomes and MeasuresThe clinical outcomes of the study were 1-year all-cause death and rehospitalization for HF. Heart failure–specific health status was assessed by the 12-Item Kansas City Cardiomyopathy Questionnaire (KCCQ-12).ResultsAmong 3386 patients, median age was 67 years (IQR, 58-75 years) and 2116 (62.5%) were men. Of these patients, 404 (11.9%) had severe PEB; 2021 (59.7%), moderate PEB; and 961 (28.4%), little PEB. Compared with patients with little PEB, those with severe PEB had increased risk of 1-year mortality (hazard ratio [HR], 1.61; 95% CI, 1.21-2.13; P &amp;lt; .001) but not 1-year HF rehospitalization (HR, 1.21; 95% CI, 0.98-1.49; P = .07). The mean (SD) adjusted KCCQ-12 score was lowest in patients with severe PEB and highest in patients with little PEB at baseline (40.0 [1.7] and 50.2 [1.0] points, respectively; P &amp;lt; .001) and at each visit (eg, 12 months: 61.5 [1.6] and 75.5 [0.9] points respectively; P &amp;lt; .001). Patients reporting severe PEB had a clinically significant lower 1-year KCCQ-12 score compared with those reporting little PEB (mean difference, −11.3 points; 95% CI, −14.9 to −7.6 points; P &amp;lt; .001).Conclusions and RelevanceIn this cohort study of patients with acute decompensated HF, greater PEB was associated with higher risk of mortality and poorer health status but not with risk of HF rehospitalization. The findings suggest that PEB may serve as a convenient tool for risk estimation and as a potential target for quality-improvement interventions for patients with HF.
Neoadjuvant Chemoimmunotherapy for NSCLC
Authors: Sorin Mark , Prosty Connor , Ghaleb Louis , Nie Kathy , Katergi Khaled , Shahzad Muhammad H. , Dubé Laurie-Rose , Atallah Aline , Swaby Anikka , Dankner Matthew , Crump Trafford , Walsh Logan A. , Fiset Pierre O. , Sepesi Boris , Forde Patrick M. , Cascone Tina , Provencio Mariano , Spicer Jonathan D. 
Published: March 2024

ImportanceTo date, no meta-analyses have comprehensively assessed the association of neoadjuvant chemoimmunotherapy with clinical outcomes in non–small cell lung cancer (NSCLC) in randomized and nonrandomized settings. In addition, there exists controversy concerning the efficacy of neoadjuvant chemoimmunotherapy for patients with NSCLC with programmed cell death 1 ligand 1 (PD-L1) levels less than 1%.ObjectiveTo compare neoadjuvant chemoimmunotherapy with chemotherapy by adverse events and surgical, pathological, and efficacy outcomes using recently published randomized clinical trials and nonrandomized trials.Data SourcesMEDLINE and Embase were systematically searched from January 1, 2013, to October 25, 2023, for all clinical trials of neoadjuvant chemoimmunotherapy and chemotherapy that included at least 10 patients.Study SelectionObservational studies and trials reporting the use of neoadjuvant radiotherapy, including chemoradiotherapy, molecular targeted therapy, or immunotherapy monotherapy, were excluded.Main Outcomes and MeasuresSurgical, pathological, and efficacy end points and adverse events were pooled using a random-effects meta-analysis.ResultsAmong 43 eligible trials comprising 5431 patients (4020 males [74.0%]; median age range, 55-70 years), there were 8 randomized clinical trials with 3387 patients. For randomized clinical trials, pooled overall survival (hazard ratio, 0.65; 95% CI, 0.54-0.79; I2 = 0%), event-free survival (hazard ratio, 0.59; 95% CI, 0.52-0.67; I2 = 14.9%), major pathological response (risk ratio, 3.42; 95% CI, 2.83-4.15; I2 = 31.2%), and complete pathological response (risk ratio, 5.52; 95% CI, 4.25-7.15; I2 = 27.4%) favored neoadjuvant chemoimmunotherapy over neoadjuvant chemotherapy. For patients with baseline tumor PD-L1 levels less than 1%, there was a significant benefit in event-free survival for neoadjuvant chemoimmunotherapy compared with chemotherapy (hazard ratio, 0.74; 95% CI, 0.62-0.89; I2 = 0%).Conclusion and RelevanceThis study found that neoadjuvant chemoimmunotherapy was superior to neoadjuvant chemotherapy across surgical, pathological, and efficacy outcomes. These findings suggest that patients with resectable NSCLC with tumor PD-L1 levels less than 1% may have an event-free survival benefit with neoadjuvant chemoimmunotherapy.
Clinical Features and Treatment Outcomes of Carbapenem-Resistant Pseudomonas aeruginosa Keratitis
Authors: Tribin Felipe Echeverri , Lieux Caroline , Maestre-Mesa Jorge , Durkee Heather , Krishna Katherine , Chou Brandon , Neag Emily , Tóthová Jana D’Amato , Martinez Jaime D. , Flynn Harry W. , Parel Jean Marie , Miller Darlene , Amescua Guillermo 
Published: March 2024

ImportanceEvaluation of the microbiological diagnostic profile of multidrug-resistant Pseudomonas aeruginosa keratitis and potential management with rose bengal–photodynamic antimicrobial therapy (RB-PDAT) is important.ObjectiveTo document the disease progression of carbapenemase-resistant P aeruginosa keratitis after an artificial tear contamination outbreak.Design, Setting, and ParticipantsThis retrospective observation case series included 9 patients 40 years or older who presented at Bascom Palmer Eye Institute and had positive test results for multidrug-resistant P aeruginosa keratitis between January 1, 2022, and October 31, 2023.Main Outcomes and MeasuresEvaluation of type III secretion phenotype, carbapenemase-resistance genes blaGES and blaVIM susceptibility to antibiotics, and in vitro and in vivo outcomes of RB-PDAT against multidrug-resistant P aeruginosa keratitis.ResultsAmong the 9 patients included in the analysis (5 women and 4 men; mean [SD] age, 73.4 [14.0] years), all samples tested positive for exoU and carbapenemase-resistant blaVIM and blaGES genes. Additionally, isolates were resistant to carbapenems as indicated by minimum inhibitory concentration testing. In vitro efficacy of RB-PDAT indicated its potential application for treating recalcitrant cases. These cases highlight the rapid progression and challenging management of multidrug-resistant P aeruginosa. Two patients were treated with RB-PDAT as an adjuvant to antibiotic therapy and had improved visual outcomes.Conclusions and RelevanceThis case series highlights the concerning progression in resistance and virulence of P aeruginosa and emphasizes the need to explore alternative therapies like RB-PDAT that have broad coverage and no known antibiotic resistance. The findings support further investigation into the potential effects of RB-PDAT for other multidrug-resistant microbes.
Binary observation‐based identification for finite impulse response systems under denial of service attacks
Authors: Wei Jingliang , Jia Ruizhe , Jing Fengwei , Guo Jin 
Published: March 2024

SummaryThis article considers the parameter identification problem for the finite impulse response system based on binary observations under denial of service attacks. First, in addition to designing the identification algorithm for the unknown parameter, and its convergence is verified, simultaneously obtaining the asymptotic normality. Then, based on the convergence speed of the identification algorithm and the covariance matrix of the estimation error, the optimal attack strategy problem is transformed into an optimization problem with constraints, then the optimal solution is given. Furthermore, a defense strategy with dual time‐scale input design method is proposed and its effectiveness is demonstrated. Finally, numerical simulations are applied to evidence the correctness of the raised method.
Self‐Carrier Nanoparticles for Delivery of Paclitaxel and IDO Inhibitor to Boost Antitumor Chemo‐Immunotherapy
Authors: Li Zixuan , Pei Qing , Zhao Min , Xie Zhigang , Zheng Min 
Published: March 2024

AbstractThe combination of chemotherapy and immunotherapy holds great potential in clinical treatment of advanced cancers. Whereas, the therapeutic outcome of chemotherapeutic and immune regulator is suboptimal due to their poor tumor availability and severe off‐target toxicity. Herein, self‐carrier nanoparticles (PSMT NPs) integrating a paclitaxel (PTX) prodrug and indoleamine 2,3‐dioxygenase 1 (IDO) inhibitor (1‐methyl‐tryptophan, 1MT) for tumor‐specific chemo‐immunotherapy is constructed. After internalization by cancer cells, PSMT NPs can respond to endogenous redox stimulus, and release PTX and 1MT. The released PTX can not only promote cell apoptosis via the intervention of cell mitosis but also initiate immunogenic cell death to facilitate the recruitment and activation of tumor‐infiltrating cytotoxic T lymphocytes. The concomitant 1MT can inhibit the IDO activity to exhaust regulatory T cells, thereby synergistically activating cytotoxic T lymphocytes. PSMT NPs exhibit potentiated antitumor output toward triple‐negative breast cancer and negligible systemic toxicity. This facile and versatile nanoplatform provides a promising strategy to cooperatively activate antitumor immunity for potentiated chemo‐immunotherapy.
Robust Thiazole‐Linked Covalent Organic Frameworks with Post‐Modified Azobenzene Groups: Photo‐Regulated Dye Adsorption and Separation
Authors: Zhao Yanli , Tao Xinfeng , Xu Binbin , Liu Wenbin , Lin Shaoliang 
Published: March 2024

AbstractDue to the intrinsic porosity and photo‐regulated pore environment, azobenzene (Azo) functionalized covalent organic frameworks (COFs) show great potential for contaminant removal. However, the stability and degree of functionality of the COFs greatly affect the porosity and subsequent adsorption capacity and selectivity. Herein, a highly stable thiazole‐linked COF containing phenolic hydroxyl groups (OH‐COF) is constructed by using 4,4′,4′‐(1,3,5‐triazine‐2,4,6‐triyl)trianiline and 2,5‐dihydroxyterephthalaldehyde in the presence of sulfur, which shows high crystallinity and specific surface. Azo‐functionalized COFs ((Azo)x‐COFs) are prepared by grafting different amounts azobenzene groups onto OH‐COF through post‐modification, whose aperture is conveniently tuned by the grafted azobenzene amount. The pore size of (Azo)x‐COFs also can be reversibly adjusted under UV and visible light irradiation without affecting the crystallinity. Appropriate amount of Azo‐grafted (Azo)0.1‐COF possessed a high adsorption capacity (1216.93 mg g−1) to Congo red (CR). While the adsorption capacity of (Azo)1.0‐COF to CR significantly increased 2.9 times to reach 1489.96 mg g−1 after UV irradiation. (Azo)1.0‐COF also can selectively separate dye molecules with different sizes based on photo‐regulated pore size, showing excellent reversibility and reusability. As such, the ability to photo‐regulate the adsorption and interception of (Azo)x‐COFs highlights their significance in functioning as smart porous nanomaterials for pollutant removal and water purification.
Low‐Dose and Stable X‐Ray Imaging Enabled by Low‐Dimensional Dion‐Jacobson Perovskites
Authors: Xin Deyu , Zhang Min , Fan Zhenghui , Yang Yujie , Dong Siyin , Lei Lin , Zhao Wei , Lin Qianqian , Zheng Xiaojia 
Published: March 2024

AbstractMetal halide perovskites have emerged as highly promising candidates for next‐generation X‐ray detectors due to their facile and low‐cost processability, high attenuation coefficient, and tunable optoelectrical properties. In this work, quasi‐2D Dion‐Jacobson (DJ) perovskites are introduced in a flat panel X‐ray imager (FPXI) for X‐ray imaging. This study demonstrates that the diammonium interlayers in DJ perovskites play a key role in enhancing structural stability, suppressing ion migration, and improving charge transport. As a result, DJ perovskite‐based X‐ray FPXIs achieve a sensitivity of 18000 µC Gyair−1 cm−2, a low detection limit of 5.7 nGyair s−1, representing performance comparable to that of state‐of‐the‐art 3D perovskite FPXIs. Thanks to the decrease in the signal crosstalk effect of the FPXIs, a high spatial resolution of 0.54 line‐pair‐per‐pixel is achieved, which is higher than that of 3D perovskite FPXIs. Remarkably, high‐quality X‐ray imaging is achieved at a total dose of 20 µGyair, which is only 1/5 of the dose typically used in commercial equipment. This work not only provides valuable insights and guidance for the fabrication of 2D DJ perovskite X‐ray detectors but also lays the groundwork for the adoption of high‐performance, stable DJ perovskite imagers as novel flat‐panel X‐ray detectors.
One‐Pot Synthesis of Luminescent and Photothermal Carbon Boron‐Nitride Quantum Dots Exhibiting Cell Damage Protective Effects
Authors: Consoli Grazia M. L. , Maugeri Ludovica , Musso Nicolò , Gulino Antonino , D'Urso Luisa , Bonacci Paolo , Buscarino Gianpiero , Forte Giuseppe , Petralia Salvatore 
Published: March 2024

AbstractZero‐dimensional boron nitride quantum dots (BNQDs) are arousing interest for their versatile optical, chemical, and biochemical properties. Introducing carbon contents in BNQDs nanostructures is a great challenge to modulate their physicochemical properties. Among the carbon moieties, phenolic groups have attracted attention for their biochemical properties and phenol‐containing nanomaterials are showing great promise for biomedical applications. Herein, the first example of direct synthesis of water dispersible BNQDs exposing phenolic and carboxylic groups is presented. The carbon‐BNQDs are prepared in a single‐step by solvent‐assisted reaction of urea with boronic reagents and are characterized by optical absorption, luminescence, Raman, Fourier transform infrared and NMR spectroscopy, X‐ray photoelectron spectroscopy, dynamic light scattering, and atomic force microscopy. The carbon‐BNQDs exhibit nanodimension, stability, high photothermal conversion efficiency, pH‐responsive luminescence and Z‐potential. The potential of the carbon‐BNQDs to provide photothermal materials in solid by embedding in agarose substrate is successfully investigated. The carbon‐BNQDs exhibit biocompatibility on colorectal adenocarcinoma cells (Caco‐2) and protective effects from chemical and oxidative stress on Caco‐2, osteosarcoma (MG‐63), and microglial (HMC‐3) cells. Amplicon mRNA‐seq analyses for the expression of 56 genes involve in oxidative‐stress and inflammation are performed to evaluate the molecular events responsible for the cell protective effects of the carbon‐BNQDs.
Ultrasound‐Activated Piezoelectric Nanoparticles Trigger Microglia Activity Against Glioblastoma Cells
Authors: Montorsi Margherita , Pucci Carlotta , De Pasquale Daniele , Marino Attilio , Ceccarelli Maria Cristina , Mazzuferi Martina , Bartolucci Martina , Petretto Andrea , Prato Mirko , Debellis Doriana , De Simoni Giorgio , Pugliese Giammarino , Labardi Massimiliano , Ciofani Gianni 
Published: March 2024

AbstractGlioblastoma multiforme (GBM) is the most aggressive brain cancer, characterized by a rapid and drug‐resistant progression. GBM “builds” around its primary core a genetically heterogeneous tumor‐microenvironment (TME), recruiting surrounding healthy brain cells by releasing various intercellular signals. Glioma‐associated microglia (GAM) represent the largest population of collaborating cells, which, in the TME, usually exhibit the anti‐inflammatory M2 phenotype, thus promoting an immunosuppressing environment that helps tumor growth. Conversely, “classically activated” M1 microglia could provide proinflammatory and antitumorigenic activity, expected to exert a beneficial effect in defeating glioblastoma. In this work, an immunotherapy approach based on proinflammatory modulation of the GAM phenotype is proposed, through a controlled and localized electrical stimulation. The developed strategy relies on the wireless ultrasonic excitation of polymeric piezoelectric nanoparticles coated with GBM cell membrane extracts, to exploit homotypic targeting in antiglioma applications. Such camouflaged nanotransducers locally generate electrical cues on GAM membranes, activating their M1 phenotype and ultimately triggering a promising anticancer activity. Collected findings open new perspectives in the modulation of immune cell activities through “smart” nanomaterials and, more specifically, provide an innovative auspicious tool in glioma immunotherapy.
In Vivo Microrheology Reveals Local Elastic and Plastic Responses Inside 3D Bacterial Biofilms
Authors: Ohmura Takuya , Skinner Dominic J. , Neuhaus Konstantin , Choi Gary P. T. , Dunkel Jörn , Drescher Knut 
Published: March 2024

AbstractBacterial biofilms are highly abundant 3D living materials capable of performing complex biomechanical and biochemical functions, including programmable growth, self‐repair, filtration, and bioproduction. Methods to measure internal mechanical properties of biofilms in vivo with spatial resolution on the cellular scale have been lacking. Here, thousands of cells are tracked inside living 3D biofilms of the bacterium Vibrio cholerae during and after the application of shear stress, for a wide range of stress amplitudes, periods, and biofilm sizes, which revealed anisotropic elastic and plastic responses of both cell displacements and cell reorientations. Using cellular tracking to infer parameters of a general mechanical model, spatially‐resolved measurements of the elastic modulus inside the biofilm are obtained, which correlate with the spatial distribution of the polysaccharides within the biofilm matrix. The noninvasive microrheology and force‐inference approach introduced here provides a general framework for studying mechanical properties with high spatial resolution in living materials.
Toward the High‐Voltage Stability of Layered Oxide Cathodes for Sodium‐Ion Batteries: Challenges, Progress, and Perspectives
Authors: Chen Zhigao , Deng Yuyu , Kong Ji , Fu Weibin , Liu Chenyang , Jin Ting , Jiao Lifang 
Published: March 2024

AbstractSodium‐ion batteries (SIBs) have garnered significant attention as ideal candidates for large‐scale energy storage due to their notable advantages in terms of resource availability and cost‐effectiveness. However, there remains a substantial energy density gap between SIBs and commercially available lithium‐ion batteries (LIBs), posing challenges to meeting the requirements of practical applications. The fabrication of high‐energy cathodes has emerged as an efficient approach to enhancing the energy density of SIBs, which commonly requires cathodes operating in high‐voltage regions. Layered oxide cathodes (LOCs), with low cost, facile synthesis, and high theoretical specific capacity, have emerged as one of the most promising candidates for commercial applications. However, LOCs encounter significant challenges when operated in high‐voltage regions such as irreversible phase transitions, migration and dissolution of metal cations, loss of reactive oxygen, and the occurrence of serious interfacial parasitic reactions. These issues ultimately result in severe degradation in battery performance. This review aims to shed light on the key challenges and failure mechanisms encountered by LOCs when operated in high‐voltage regions. Additionally, the corresponding strategies for improving the high‐voltage stability of LOCs are comprehensively summarized. By providing fundamental insights and valuable perspectives, this review aims to contribute to the advancement of high‐energy SIBs.
Customized Enhancement of Thermal Sensitivity of Tumors at Different Subcutaneous Depths by Multichannel Lanthanide Nanocomposites
Authors: Liu Yuxin , Wei Zheng , Zhang Jieying , Xu Yang , Zhou Jing , Ma Zhanfang , Mutti Francesco G. , Zhang Hong , Zhu Xingjun , Loeffler Felix F. 
Published: March 2024

AbstractThe photothermal therapeutic effect on tumors located at different subcutaneous depths varies due to the attenuation of light by tissue. Here, based on the wavelength‐dependent optical attenuation properties of tissues, the tumor depth is assessed using a multichannel lanthanide nanocomposite. A zeolitic imidazolate framework (ZIF‐8)‐coated nanocomposite is able to deliver high amounts of the hydrophilic heat shock protein 90 inhibitor epigallocatechin gallate through a hydrogen‐bonding network formed by the encapsulated highly polarized polyoxometalate guest. It is superior to both bare and PEGylated ZIF‐8 for drug delivery. With the assessment of tumor depth and accumulated amount of nanocomposite by fluorescence, an irradiation prescription can be customized to release sufficient HSP90 inhibitor and generate heat for sensitized photothermal treatment of tumors, which not only ensured therapeutic efficacy but also minimized damage to the surrounding tissues.
Electrocorticogram (ECoG): Engineering Approaches and Clinical Challenges for Translational Medicine
Authors: Moon Hyunmin , Kwon Jii , Eun Jonghee , Chung Chun Kee , Kim June Sic , Chou Namsun , Kim Sohee 
Published: March 2024

AbstractElectrocorticogram (ECoG) is an electrophysiological signal that results from the summation of neuronal activity near the cortical surface. To record ECoG signals, the scalp and skull are surgically opened and electrodes are placed on the cortical surface, either epidurally or subdurally. Owing to its improved spatiotemporal resolution and signal quality compared with electroencephalography, it is widely used to diagnose and treat neurological disorders in clinical settings for several decades, despite the invasiveness of ECoG. Recently, ECoG is applied in research to explore brain functions and connectivity, brain‐computer interfaces, and brain‐machine interfaces. In addition to the need for ECoG in neuroscience research, ECoG devices have advanced in terms of materials, fabrication, and function to overcome the limitations of commercially available ECoG arrays. Here, the conventional use of ECoG in clinical medicine, the new applications of ECoG in basic neuroscience research, and the future challenges in translating recent developments in ECoG devices for clinical use are described.