bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health, Religion, and Politics: Re-assessing the Role of Christian Missionaries in Colonial Assam
Authors: Jagriti  , Sengupta Madhumita 
Published: March 2024

Abstract
Most studies of Christian missionaries in British Assam have focused on their role in promoting Christianity or education, not to mention their contributions to the development and standardization of local languages. There has been a singular lack of studies concerning the immense contributions made by the missionaries in setting up a healthcare infrastructure in the region. This absence has further distorted the debate on whether the missionaries operated as independent agents or as auxiliaries of the state. This paper dwells on the medical work carried out by the missionaries in British Assam and contends that the missionaries fulfilled multiple roles and functions in the province. We argue that the significance of the work of the missionaries is enhanced by the utter neglect of healthcare by the colonial state in the frontier region.
Migration of Telugu Catholics in Madras Presidency – ce 1780–1910
Authors: Joseph Martin 
Published: March 2024

Abstract
The Catholic dioceses of Madras-Mylapore and Chingleput are home to 44 Telugu Catholic villages. These villages were established between 1780 and 1910 by Telugu Catholics who migrated from Andhra Pradesh to Tamil Nadu. This article delves into archival materials to trace the origins and destinations of these migrants, the factors that prompted their migration, the key protagonists and institutions involved, the caste dynamics at play, the assimilation process, and the contributions they made to the local society from a historical perspective. While this article primarily focuses on research about early colonial peasant migrations, it also explores the micro history of the Telugu community, offering insights into the challenges faced by contemporary migrations, including issues of land ownership, citizenship, and identity crisis. Furthermore, it analyses the post-migration environment, highlighting the social interactions, as well as the cultural, religious, and spiritual experiences of these communities. This analysis aims to demonstrate how these Telugu communities have successfully assimilated into the local society while preserving their unique identities.
Delivering an Improved Framework for the New Generation of CMIP6-Driven EURO-CORDEX Regional Climate Simulations
Authors: Katragkou E. , Sobolowski S. P. , Teichmann C. , Solmon F. , Pavlidis V. , Rechid D. , Hoffmann P. , Fernandez J. , Nikulin G. , Jacob D. 
Published: March 2024

Abstract
The Coordinated Regional Downscaling Experiment (CORDEX) is a coordinated international activity that has produced ensembles of regional climate simulations with domains that cover all land areas of the world. These ensembles are used by a wide range of practitioners that include the scientific community, policymakers, and stakeholders from the public and private sectors. They also provide the scientific basis for the Intergovernmental Panel on Climate Change-Assessment Reports. As its next phase now launches, the CMIP6-CORDEX datasets are expected to populate community repositories over the next couple of years, with updated state-of-the-art regional climate data that will further support national and regional communities and inform their climate adaptation and mitigation strategies. The protocol presented here focuses on the European domain (EURO-CORDEX). It takes the international CORDEX protocol covering all 14 global domains as its template. However, it expands on the international protocol in specific areas; incorporates historical and projected aerosol trends into the regional models in a consistent way with CMIP6 global climate models, to allow for a better comparison of global versus regional trends; produces more climate variables to better support sectorial climate impact assessments; and takes into account the recent scientific developments addressed in the CORDEX Flagship Pilot Studies, enabling a better assessment of processes and phenomena relevant to regional climate (e.g., land-use change, aerosol, convection, and urban environment). Here, we summarize the scientific analysis which led to the new simulation protocol and highlight the improvements we expect in the new generation regional climate ensemble.
Water Vapor Lidar Observation and Data Assimilation for a Moist Low-Level Jet Triggering a Mesoscale Convective System
Authors: Yoshida Satoru , Sakai Tetsu , Nagai Tomohiro , Ikuta Yasutaka , Kato Teruyuki , Shiraishi Koichi , Kato Ryohei , Seko Hiromu 
Published: March 2024

Abstract
We conducted field observations using two water vapor Raman lidars (RLs) in Kyushu, Japan, to clarify the characteristics of a moist low-level jet (MLLJ), which plays a fundamental role in the formation and maintenance of mesoscale convective systems (MCSs). The two RLs observed the inside and outside of an MLLJ, providing moisture to an MCS with local heavy precipitation on 9 July 2021. Our observations revealed that the MLLJ contained large amounts of moisture below the convective mixing layer height of 1.6 km. The large amount of moisture in the MLLJ might be intensified by low-level convergences and/or water vapor buoyancy facilitated by strong horizontal wind. We conducted four data assimilation experiments: CNTL that assimilated Japan Meteorological Agency operational observation data and three other experiments that ingested the lidar-derived vertical moisture profiles as well as the operational observation data. The experiments assimilating lidar-derived vertical moisture profiles caused intensification and southwestward extensions of the low-level convergence zone, resulting in local heavy precipitation at lower latitudes in experiments assimilating lidar-derived moisture profiles than in CNTL. All three experiments ingesting vertical moisture profiles generally produced better 9-h precipitation forecasts than CNTL, implying that the assimilation of vertical moisture profiles could be well suited for numerical weather prediction of local heavy precipitation. Moreover, the experiment assimilating both of the two RL sites’ data reproduced better forecast fields than experiments assimilating a single RL site’s data, implying that data assimilation of vertical moisture profiles at multiple RL sites enables us to improve initial conditions compared to a single RL site.

Significance Statement
Moist low-level jets (MLLJs) are moisture-rich airflows in the low-level atmosphere that play an important role in developing mesoscale convective systems and local heavy rainfall. To better understand the mechanisms affecting the development of local heavy rainfall events and to improve our ability to forecast them, studying the moisture structures in MLLJs is important. We succeeded in observing an MLLJ in western Japan using water vapor Raman lidars (RLs), which obtained vertical moisture profiles, and revealed details of vertical moisture structures in the MLLJ. We also performed data assimilation experiments to examine the impact of assimilating vertical moisture profiles observed by the RLs. The results showed that the assimilation of the moisture data improved the forecasting of local heavy rainfall.
5-Year Radiographic and Functional Outcomes of Nonoperative Treatment of Completely Displaced Midshaft Clavicular Fractures in Teenagers
Authors: Polinsky Samuel G. , Edmonds Eric W. , Bastrom Tracey P. , Manhard Claire E. , Heyworth Benton E. ,   FACTS Study Group:, Bae Donald S. , Busch Michael T. , Ellis Henry B. , Hergott Katelyn , Kocher Mininder S. , Li Ying , Nepple Jeffrey J. , Pandya Nirav K. , Perkins Crystal , Sabatini Coleen S. , Spence David D. , Willimon Samuel C. , Wilson Philip L. , Pennock Andrew T. 
Published: March 2024

Background: Optimal treatment of completely displaced midshaft clavicular fractures in adolescents remains controversial, with some favoring surgical management and others favoring a nonoperative approach. Few studies have comprehensively assessed longer-term nonoperative outcomes. Purpose: To prospectively assess patient-reported outcomes (PROs) and radiographic remodeling ≥5 years after injury in teenagers undergoing nonoperative treatment of completely displaced clavicular fractures. Study Design: Case series; Level of evidence, 4. Methods: Adolescent patients previously enrolled in a prospective study from a single institution with nonoperatively treated, completely displaced midshaft clavicular fractures ≥5 years from injury were eligible for the study. Patients were clinically evaluated for scapular dyskinesia and strength deficits. Bilateral clavicular imaging assessed residual shortening, displacement, and angulation. PROs included the American Shoulder and Elbow Surgeons (ASES), the shortened version of the Disabilities of the Arm, Shoulder and Hand (QuickDASH), Marx Shoulder Activity Scale, cosmesis, and return to sports data. Results: A total of 24 patients were available for the follow-up, of whom 17 (71%) consented to additional imaging. The mean cohort age at the time of injury was 14.5 ± 1.1 years, with 88% being male. At a mean follow-up of 6.1 years, all fractures had healed, with no patient requiring secondary interventions. Significant remodeling was observed across all measurements, with improvements of 70% in shortening (22.8 to 6.8 mm; P < .001), 73% in superior displacement (13.4 to 3.6 mm; P < .001), and 83% in angulation (10.4° to 1.8°; P < .001). Thirteen patients (72%) had a >2-cm initial shortening, and all remodeled to <2 cm. PROs were almost universally excellent, with mean ASES, QuickDASH, and Marx activity scores of 99 ± 3, 1 ± 3, and 20 ± 1, respectively, with 79% of patients reporting perfect scores in all 3 domains. Most patients (58%) were completely satisfied with their shoulder appearance, 38% were more satisfied than not, 1 patient (4%) was neither satisfied nor dissatisfied, and no patients were dissatisfied. All patients except 1 who were interested in sports returned to sporting activities. PROs were not associated with bony remodeling ( P > .05). Conclusion: Teenaged patients with completely displaced clavicular fractures treated nonoperatively can expect excellent radiographic and clinical outcomes 5 years after injury.
Acellular Aragonite-Based Scaffold for the Treatment of Joint Surface Lesions of the Knee: A Minimum 5-Year Follow-Up Study
Authors: de Caro Francesca , Vuylsteke Kristien , Van Genechten Wouter , Verdonk Peter 
Published: March 2024

Objective A novel aragonite-based scaffold has been developed. In this study, mid-term clinical and magnetic resonance imaging (MRI) results on 12 patients affected by isolated chondral or osteochondral lesions of the knee treated by the scaffold implantation have been evaluated at a mean follow-up of 6.5 (range: 5-8) years. Design The study population consisted of 3 females and 9 males, mean age 34.4 (20-51) years. The lesion was located on the medial femoral condyle, the trochlea, and the lateral femoral condyle in 5, 5, and 2 patients, respectively. In all cases, a single lesion over grade 3 of the International Cartilage Restoration and Joint Preservation Society (ICRS) classification was treated: in 9 cases by implantation of one plug, and in 2 cases with 2 plugs; the mean size of the lesion was 2.5 cm2 (1-7). Results One patient failed and was revised with a custom-made metal implant (Episealer). Overall, Knee Injury and Osteoarthritis Outcome Score (KOOS) significantly improved from 45 ± 13 preoperatively to 86 ± 13 at final follow-up. All KOOS subscales improved significantly: pain subscale increased from 48 ± 12 to 92 ± 11; symptoms from 66 ± 13 to 91 ± 13; activity of daily living (ADL) from 60 ± 19 to 90 ± 21; sport from 23 ± 20 to 75 ± 20; finally, quality of life (QoL) increased from 27 ± 14 to 77 ± 19. Long-term MRI MOCART score was 64. Conclusions This study shows continued significant clinical improvement and good magnetic resonance imaging (MRI) findings with a minimum 5 years follow-up after implantation of a novel aragonite derived scaffold for the treatment of cartilage lesions of the knee. One patient failed and was revised with a custom-made metal implant (Episealer).
i5mC-DCGA: an improved hybrid network framework based on the CBAM attention mechanism for identifying promoter 5mC sites
Authors: Jia Jianhua , Lei Rufeng , Qin Lulu , Wei Xin 
Published: March 2024

Abstract
Background
5-Methylcytosine (5mC) plays a very important role in gene stability, transcription, and development. Therefore, accurate identification of the 5mC site is of key importance in genetic and pathological studies. However, traditional experimental methods for identifying 5mC sites are time-consuming and costly, so there is an urgent need to develop computational methods to automatically detect and identify these 5mC sites.

Results
Deep learning methods have shown great potential in the field of 5mC sites, so we developed a deep learning combinatorial model called i5mC-DCGA. The model innovatively uses the Convolutional Block Attention Module (CBAM) to improve the Dense Convolutional Network (DenseNet), which is improved to extract advanced local feature information. Subsequently, we combined a Bidirectional Gated Recurrent Unit (BiGRU) and a Self-Attention mechanism to extract global feature information. Our model can learn feature representations of abstract and complex from simple sequence coding, while having the ability to solve the sample imbalance problem in benchmark datasets. The experimental results show that the i5mC-DCGA model achieves 97.02%, 96.52%, 96.58% and 85.58% in sensitivity (Sn), specificity (Sp), accuracy (Acc) and matthews correlation coefficient (MCC), respectively.

Conclusions
The i5mC-DCGA model outperforms other existing prediction tools in predicting 5mC sites, and it is currently the most representative promoter 5mC site prediction tool. The benchmark dataset and source code for the i5mC-DCGA model can be found in https://github.com/leirufeng/i5mC-DCGA.
Uncovering the complexity of childhood undernutrition through strain-level analysis of the gut microbiome
Authors: Chang Bingmei , Zhang Wenjie , Wang Yinan , Zhang Yuanzheng , Zhong Shilin , Gao Peng , Wang Lili , Zhao Zicheng 
Published: March 2024

Abstract
Background
Undernutrition (UN) is a critical public health issue that threatens the lives of children under five in developing countries. While evidence indicates the crucial role of the gut microbiome (GM) in UN pathogenesis, the strain-level inspection and bacterial co-occurrence network investigation in the GM of UN children are lacking.

Results
This study examines the strain compositions of the GM in 61 undernutrition patients (UN group) and 36 healthy children (HC group) and explores the topological features of GM co-occurrence networks using a complex network strategy. The strain-level annotation reveals that the differentially enriched species between the UN and HC groups are due to discriminated strain compositions. For example, Prevotella copri is mainly composed of P. copri ASM1680343v1 and P. copri ASM345920v1 in the HC group, but it is composed of P. copri ASM346549v1 and P. copri ASM347465v1 in the UN group. In addition, the UN-risk model constructed at the strain level demonstrates higher accuracy (AUC = 0.810) than that at the species level (AUC = 0.743). With complex network analysis, we further discovered that the UN group had a more complex GM co-occurrence network, with more hub bacteria and a higher clustering coefficient but lower information transfer efficiencies. Moreover, the results at the strain level suggested the inaccurate and even false conclusions obtained from species level analysis.

Conclusions
Overall, this study highlights the importance of examining the GM at the strain level and investigating bacterial co-occurrence networks to advance our knowledge of UN pathogenesis.
Transcriptome and metabolome profiling reveal the effects of hormones on current-year shoot growth in Chinese ‘Cuiguan’ pear grafted onto vigorous rootstock ‘Duli’ and dwarf rootstock ‘Quince A’
Authors: Liang Zhenxu , Wang Qinghua , Sun Mingde , Du Ruirui , Jin Wanmei , Liu Songzhong 
Published: March 2024

Abstract
Background
Dwarf rootstocks have important practical significance for high-density planting in pear orchards. The shoots of ‘Cuiguan’ grafted onto the dwarf rootstock were shorter than those grafted onto the vigorous rootstock. However, the mechanism of shorter shoot formation is not clear.

Results
In this study, the current-year shoot transcriptomes and phytohormone contents of ‘CG‒QA’ (‘Cuiguan’ was grafted onto ‘Quince A’, and ‘Hardy’ was used as interstock) and ‘CG‒DL’ (‘Cuiguan’ was grafted onto ‘Duli’, and ‘Hardy’ was used as interstock) were compared. The transcriptome results showed that a total of 452 differentially expressed genes (DEGs) were identified, including 248 downregulated genes and 204 upregulated genes; the plant hormone signal transduction and zeatin biosynthesis pathways were significantly enriched in the top 20 KEGG enrichment terms. Abscisic acid (ABA) was the most abundant hormone in ‘CG‒QA’ and ‘CG‒DL’; auxin and cytokinin (CTK) were the most diverse hormones; additionally, the contents of ABA, auxin, and CTK in ‘CG‒DL’ were higher than those in ‘CG‒QA’, while the fresh shoot of ‘CG‒QA’ accumulated more gibberellin (GA) and salicylic acid (SA). Metabolome and transcriptome co-analysis identified three key hormone-related DEGs, of which two (Aldehyde dehydrogenase gene ALDH3F1 and YUCCA2) were upregulated and one (Cytokinin oxidase/dehydrogenase gene CKX3) was downregulated.

Conclusions
Based on the results of transcriptomic and metabolomic analysis, we found that auxin and CTK mainly regulated the shoot differences of ‘CG–QA’ and ‘CG–DL’, and other hormones such as ABA, GA, and SA synergistically regulated this process. Three hormone-related genes ALDH3F1, YUCCA2, and CKX3 were the key genes contributing to the difference in shoot growth between ‘CG–QA’ and ‘CG–DL’ pear. This research provides new insight into the molecular mechanism underlying shoot shortening after grafted onto dwarf rootstocks.
The effects of robot-assisted laparoscopic surgery with Trendelenburg position on short-term postoperative respiratory diaphragmatic function
Authors: Xue Shuo , Wang Dan , Tu Hong-Qin , Gu Xiao-Ping , Ma Zheng-Liang , Liu Yue , Zhang Wei 
Published: March 2024

Abstract
Objective
To study how Pneumoperitoneum under Trendelenburg position for robot-assisted laparoscopic surgery impact the perioperative respiratory parameters, diagrammatic function, etc.

Methods
Patients undergoing robot-assisted laparoscopic surgery in the Trendelenburg position and patients undergoing general surgery in the supine position were selected. The subjects were divided into two groups according to the type of surgery: robot-assisted surgery group and general surgery group. ① Respiratory parameters such as lung compliance, oxygenation index, and airway pressure were recorded at 5 min after intubation, 1 and 2 h after pneumoperitoneum. ② Diaphragm excursion (DE) and diaphragm thickening fraction (DTF) were recorded before entering the operating room (T1), immediately after extubation (T2), 10 min after extubation (T3), and upon leaving the postanesthesia care unit (T4). ③ Peripheral venous blood (5 ml) was collected before surgery and 30 min after extubation and was analyzed by enzyme-linked immunosorbent assay to determine the serum concentration of Clara cell secretory protein 16 (CC16) and surfactant protein D (SP-D).

Result
① Compared with the general surgery group (N = 42), the robot-assisted surgery group (N = 46) presented a significantly higher airway pressure and lower lung compliance during the surgery(P < 0.001). ② In the robot-assisted surgery group, the DE significantly decreased after surgery (P < 0.001), which persisted until patients were discharged from the PACU (P < 0.001), whereas the DTF only showed a transient decrease postoperatively (P < 0.001) and returned to its preoperative levels at discharge (P = 0.115). In the general surgery group, the DE showed a transient decrease after surgery(P = 0.011) which recovered to the preoperative levels at discharge (P = 1). No significant difference in the DTF was observed among T1, T2, T3, and T4. ③ Both the general and robot-assisted surgery reduced the postoperative serum levels of SP-D (P < 0.05), while the robot-assisted surgery increased the postoperative levels of CC16 (P < 0.001).

Conclusion
Robot-assisted laparoscopic surgery significantly impairs postoperative diaphragm function, which does not recover to preoperative levels at PACU discharge. Elevated levels of serum CC16 after surgery suggest potential lung injury. The adverse effects may be attributed to the prolonged Trendelenburg position and pneumoperitoneum during laparoscopic surgery.
Transvenous endocardial pacing with SelectSecure™ 3830 lead in pediatric patients: case series of two infants and a literature review
Authors: Yang Chuan , Qi Jing , Alam Mahmood , Zou Deling 
Published: March 2024

Abstract
Background
The SelectSecure™ 3830 lead is an innovative, lumenless, and thin active fixed lead with a nonretractable screw-in tip and a diameter of 4.1 Fr, making it the thinnest pacing lead available. Its high anti-extrusion properties and durability have shown favorable outcomes in cardiac pacing, especially in pediatric patients. The superfine design and easy implantation of the lead have rendered it a preferred choice in children, particularly in cases of congenital heart disease.

Case presentation
This case series presents two infant patients who underwent transvenous endocardial pacing using the SelectSecure™ 3830 lead, along with a comprehensive literature review on the topic. The study followed the patients for 5 years and 3 years, respectively, and observed stable pacing parameters, indicating a positive therapeutic outcome and safety.
This article discusses the optimal age and body shape for transvenous lead implantation in infants and highlights the advantages and disadvantages of endocardial and epicardial pacing approaches. Although endocardial pacing offers several benefits such as minimal trauma, short hospital stay, and longer battery life, it may not be suitable for intracardiac shunts, and venous occlusion remains a concern. On the other hand, epicardial pacing may be considered for children with challenging endocardial access but comes with higher risk of lead failure and coronary artery compression.
This study emphasizes the importance of careful follow-up in pediatric patients with pacing, as lead failure can occur in young patients owing to growth and development, leading to syncope and battery depletion. The article also underscores the significance of selecting the appropriate pacing location to minimize the impact of cardiac function, with right ventricular septal pacing emerging as a preferable option.

Conclusions
The SelectSecure™ 3830 lead presents a promising solution for transvenous endocardial pacing in pediatric patients with high degree atrioventricular block and bradycardia, ensuring safe and effective pacing as they grow and develop.