bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful treatment of severe heart failure in an infant with Hurler syndrome
Authors: Hirth A. , Berg A. , Greve G. 
Published: September 2007

SummaryHurler syndrome (MPS IH) is the most severe form of mucopolysaccharidosis type I. It is caused by deficiency or absence of the enzyme α‐l‐iduronidase. Cardiac involvement includes cardiomyopathy and valve and coronary pathology. Cardiomyopathy causing symptoms in an infant with MPS IH carries a very poor prognosis. We describe a previously healthy 10‐week‐old boy who was admitted to hospital critically ill with severe heart failure. Echocardiography on admission showed severe dilatation of the left ventricle and moderate insufficiency of the left‐sided cardiac valves. Accumulation of heparan sulfate and dermatan sulfate substrates in the urine and leukocyte analysis confirmed the diagnosis of MPS IH. Enzyme replacement therapy (ERT) with intravenous laronidase at a standard dosage of 100 U/kg weekly was started soon after. This improved the child's general clinical wellbeing dramatically. His cardiac function improved steadily over a period of months. Stem cell transplantation from cord blood is not available in Norway and he underwent successful transplantation from an unrelated bone marrow donor at the age of 11 months. ERT was stopped four months later. At the age of 26 months his heart function is close to normal and he is currently on no medication. This report highlights three important clinical issues: (1) MPS IH must be considered in infants with cardiomyopathy; (2) early ERT may have a significant impact on short‐term outcome in children less than 18 months old with severe cardiomyopathy; (3) our report confirms that patients in poor condition benefit from ERT before stem cell transplantation.
Peptides reproducibly released byin vivodigestion of beef meat and trout flesh in pigs
Authors: Bauchart Caroline , Morzel Martine , Chambon Christophe , Mirand Philippe Patureau , Reynès Christelle , Buffière Caroline , Rémond Didier 
Published: September 2007

Characterisation and identification of peptides (800 to 5000 Da) generated by intestinal digestion of fish or meat were performed using MS analyses (matrix-assisted laser desorption ionisation time of flight and nano-liquid chromatography electrospray-ionisation ion trap MS/MS). Four pigs fitted with cannulas at the duodenum and jejunum received a meal exclusively made of cookedPectoralis profundusbeef meat or cooked trout fillets. A protein-free meal, made of free amino acids, starch and fat, was used to identify peptides of endogenous origin. Peptides reproducibly detected in digesta (i.e. from at least three pigs) were evidenced predominantly in the first 3 h after the meal. In the duodenum, most of the fish- and meat-derived peptides were characteristic of a peptic digestion. In the jejunum, the majority of peptides appeared to result from digestion by chymotrypsin and trypsin. Despite slight differences in gastric emptying kinetics and overall peptide production, possibly in relation to food structure and texture, six and four similar peptides were released after ingestion of fish or meat in the duodenum and jejunum. A total of twenty-six different peptides were identified in digesta. All were fragments of major structural (actin, myosin) or sarcoplasmic (creatine kinase, glyceraldehyde-3-phosphate dehydrogenase and myoglobin) muscle proteins. Peptides were short ( < 2000 Da) and particularly rich in proline residues. Nineteen of them contained bioactive sequences corresponding mainly to an antihypertensive activity. The present work showed that after fish or meat ingestion, among the wide variety of peptides produced by enzymic digestion, some of them can be reproducibly observed in intestinal digesta.
Influence of Ramadan-type fasting on carbohydrate metabolism, brush border membrane enzymes and phosphate transport in rat kidney used as a model
Authors: Salim Samina , Farooq Neelam , Priyamvada Shubha , Asghar Mohammad , Jalal Khundmiri Syed , Khan Samia , Khan Farah , Yusufi Ahad Noor Khan 
Published: September 2007

Ramadan fasting is a unique model of fasting in which Muslims the world over abstain from food and water from dawn to sunset for 1 month. We hypothesized that this model of prolonged intermittent fasting would result in specific adaptive alterations in rat kidney to keep a positive balance of metabolites and inorganic phosphate (Pi). The effect of Ramadan-type fasting was studied on enzymes of carbohydrate metabolism and brush border membrane (BBM) and BBM uptake of32Pi in different renal tissue zones in the rat model. Rats were fasted (12 h) and then re-fed (12 h) daily for 30 d similar to human Ramadan fasting. Ramadan-type fasting resulted in increased serum Pi and phospholipids, whereas Pi clearance decreased. Serum creatinine and its clearance were not affected. Fasting caused a significant decrease in the activities of lactate and malate dehydrogenases, glucose-6-phosphatase and fructose-1,6-bisphosphatase, both in the renal cortex and medulla. However, the activity of glucose-6-phosphate dehydrogenase profoundly increased but that of malic enzyme decreased. The activities of alkaline phosphatase and γ-glutamyl transpeptidase in BBM decreased, whereas transport of32Pi significantly increased. The decrease in enzyme activities and increase in32Pi transport were due to alterations of both maximal velocities and relative affinities. The results indicate that Ramadan-type fasting caused specific metabolic alterations with enhanced Pi conservation in different kidney tissues in a rat model used for Ramadan fasting in man.
Improvement of bone properties and enhancement of mineralization by ethanol extract of Fructus Ligustri Lucidi
Authors: Zhang Yan , Leung Ping-Chung , Che Chun-Tao , Chow Hung-Kay , Wu Chun-Fu , Wong Man-Sau 
Published: September 2007

Fructus Ligustri Lucidi (FLL), a kidney-tonifying Chinese herb, was shown to regulate Ca balance in ovariectomized (OVX) rats in our previous study. This study investigated whether it could improve bone properties in aged normal and OVX rats and increase osteoblastic differentiation in rat osteoblast-like UMR-106 cells. Ten-month-old aged rats underwent sham-operation or ovariectomy, were orally administered with FLL extracts or its vehicle and fed with diets containing different levels of Ca (LCD, 0·1 % Ca; MCD, 0·6 % Ca; HCD, 1·2 % Ca) for 12 weeks. Ovariectomy induced bone loss at multiple-sites of both tibia and femur in all rats being studied. FLL extract increased bone mineral density and bone mineral content at both tibial and femoral diaphysis as well as the lumbar vertebra (LV-2) in rats fed either LCD or MCD. In addition, FLL increased biomechanical strength of the tibial diaphysis in these rats. Combination of FLL and high-Ca diet significantly improved bone mass of cortical and trabecular bone at appendicular bones and LV-2 and decreased bone loss associated with ovarietomy and low-Ca feeding. Treatment of UMR-106 cells with FLL extracts accelerated the formation of calcified matrix and increased extracellular Ca and P depositions in time- and dose-dependent manner. The level of mineralization reached a maximum by 6 d incubation at the dosage of 10 μg FLL extract/ml. Our study indicated that FLL extract could improve bone properties in aged rats possibly via its direct action on osteoblastic cells by enhancement of the mineralization process.
Dietary supplement use and mortality in a cohort of Swedish men
Authors: Messerer Maria , Håkansson Niclas , Wolk Alicja , Åkesson Agneta 
Published: September 2007

The use of dietary supplements has increased substantially in most industrialized countries. The aim of this study was to prospectively examine the association between use of dietary supplements and all-cause mortality, cancer mortality and CVD mortality in men. We used the population-based prospective cohort of 38 994 men from central Sweden, 45–79 years of age, with no cancer or CVD at baseline and who completed a self-administered FFQ including questions on dietary supplement use and life-style factors in 1997. During average 7.7 years of follow-up, 3403 deaths were ascertained; among them, 771 due to cancer and 930 due to CVD (during 5.9 years of follow-up). In multivariate adjusted models including all men there was no association observed between use of any dietary supplement or of multivitamins, vitamin C, vitamin E or fish oil specifically and all-cause mortality, cancer or CVD mortality. Among current smokers, regular use of any supplement was associated with statistically significant increased risk of cancer mortality: relative risk (RR) 1·46 (95 % CI 1·06, 1·99). Among men reporting an inadequate diet at baseline (assessed by Recommended Food Score), there was a statistically significant inverse association between use of any dietary supplement and CVD mortality (RR 0·72; 95 % CI 0·57, 0·91), no associations were observed among men with adequate diets. In conclusion, we cannot exclude that the use of dietary supplements is harmful for smokers. On the other hand, among men with an insufficient diet, the use of supplements might be beneficial in reducing CVD mortality.
Reproducibility and relative validity of dietary glycaemic index and load assessed with a self-administered diet-history questionnaire in Japanese adults
Authors: Murakami Kentaro , Sasaki Satoshi , Takahashi Yoshiko , Okubo Hitomi , Hirota Naoko , Notsu Akiko , Fukui Mitsuru , Date Chigusa 
Published: September 2007

Although many epidemiological studies have examined the association of dietary glycaemic index (GI) and glycaemic load (GL) with health outcomes, information on the reproducibility and relative validity of these variables estimated from dietary questionnaires is extremely limited. We examined the reproducibility and relative validity of dietary GI and GL assessed with a self-administered diet-history questionnaire (DHQ) in adult Japanese. A total of ninety-two Japanese women and ninety-two Japanese men aged 31–76 years completed the DHQ (assessing diet during the preceding month) and 4 d dietary records (DR) in each season over a 1-year period (DHQ1–4 and DR1–4, respectively) and the DHQ at 1 year after completing DHQ1 (DHQ5). We used intraclass correlations between DHQ1 and DHQ5 to assess reproducibility, and Pearson correlations between the mean of DR1–4 and mean of DHQ1–4 and between the mean of DR1–4 and DHQ1 to assess relative validity. Reproducibility correlations for dietary GI and GL were 0·57 and 0·69 among women and 0·65 and 0·58 among men, respectively. Validity correlations for dietary GI and GL assessed by DHQ1–4 were 0·72 and 0·66 among women and 0·65 and 0·71 among men, respectively. Corresponding correlations for DHQ1 were 0·53 and 0·58 among women and 0·57 and 0·60 among men, respectively. White rice was the major contributor to GI and GL in both methods (49–64 %). These data indicate reasonable reproducibility and relative validity of dietary GI and GL assessed by a DHQ for Japanese adults, whose dietary GI and GL are primarily determined by the GI of white rice.
RELIGION AND RITUAL IN THE WESTERN PROVINCES
Authors: REVELL LOUISE 
Published: September 2007

IntroductionThe search for a more powerful entity to provide some form of order to the chaotic nature of human existence is a phenomenon that can be seen throughout much of human history. For a Roman, the gods were everywhere, as powerful forces with an interest in all aspects of daily life. Religion formed part of the broad-based homogeneity of the western provinces following the process of cultural transformation after conquest. Inscriptions, sculpture, and temple architecture all point to a similar material culture, and, although there is an apparent continuity in the names of the deities being worshipped from the pre-Roman to the Roman periods, their association with the traditional gods of Rome through syncretism negates the idea of direct continuity. However, religious changes are often overlooked in accounts of the Romanization of the western provinces, and we are left with the rather uncritical concept of ‘Romano-Celtic’ religion as a hybrid phenomenon. There is a danger of using the archaeological evidence of temples and inscriptions as diagnostic of change, rather than undertaking a more rigorous analysis in order to understand how religion and ritual formed part of this broad-based homogeneity, and the way in which the people of the provinces made sense of how to act and behave within a new social and political world.
Moral Status in Virtue Ethics
Authors: Hacker-Wright John 
Published: September 2007

AbstractMy contention is that virtue ethics offers an important critique of traditional philosophical conceptions of moral status as well as an alternative view of important moral issues held to depend on moral status. I argue that the scope of entities that deserve consideration depends on our conception of the demands of virtues like justice; which entities deserve consideration emerges from a moral view of a world shaped by that conception. The deepest disputes about moral status depend on conflicting conceptions of justice. I advocate a conception of the virtue of justice that can account for the cases that pose problems for the legalistic views of moral status and discuss what ideal moral debate looks like on this view.
Is the Feeling of Unity That Kant Identifies in his Third Critique a Type of Inexpressible Knowledge?
Authors: Moore A.W. 
Published: September 2007

AbstractKant, in his third Critique, confronts the issue of how rule-governed objective judgement is possible. He argues that it requires a particular kind of aesthetic response to one's experience. I dub this response ‘the Feeling of Unity’, and I raise the question whether it is a type of inexpressible knowledge. Using David Bell's account of these matters as a touchstone, I argue that it is.
Gross for kids but good for parents: differing messages in advertisements for the same products
Authors: Jones Sandra , Fabrianesi Belinda 
Published: September 2007

AbstractObjectivesThere has been surprisingly little research into the effects of food advertising on parents’ perception of commonly consumed children’s food items, although the available research suggests that parents may find nutritional claims in these advertisements confusing. The purpose of the present study was to investigate parents’ perceptions of branded snack foods targeted at children, and the extent to which these perceptions are influenced by advertising messages.DesignUsing an intercept survey, participants were shown either adult-targeted or child-targeted advertisements for the same food products.SettingCentral business district of a major Australian city.SubjectsOne hundred adults, mean age 40 years.ResultsThe study results suggest that: (1) adults’ perceptions of advertised food products and, most importantly, purchase intentions for those products differ according to the version of the advertisement seen (for three of the products, 42–54% would buy the product after seeing the child version compared with 82–84% after seeing the adult version); and (2) adults clearly perceive distinctly different messages in advertisements for the same products which are targeting parents vs. those targeting children (e.g. for three of the products, 74–92% perceived that the adult version of the advertisement suggested the food was nutritionally beneficial compared with 2–14% perceiving this for the child version).ConclusionsIt is clear that the messages conveyed to children about specific foods are quite different to the messages conveyed to adults – and importantly parents – about the same foods.
Determinants of compliance with iron supplementation among pregnant women in Senegal
Authors: Seck Binetou C , Jackson Robert T 
Published: September 2007

AbstractBackgroundCommunity iron supplementation programmes for pregnant women have lacked effectiveness, partly because of low compliance.ObjectiveTo determine factors that influence compliance among pregnant women in Senegal.DesignTwo hundred and twenty-one pregnant women, recruited from six health centres in Dakar during their first prenatal visit, were randomly assigned to receive either a prescription to purchase iron/folic acid tablets (control, n = 112) to be taken daily, according to official policy, or to receive free tablets (treatment, n = 109). Compliance was assessed 20 weeks after enrolment through interviews and pill count. Women with low or high compliance (<70% or ≥70%) were asked to explain what influenced their adherence to supplementation.ResultsOverall compliance was 69%; it was significantly higher in the treatment than in the control group (86% vs. 48%; P < 0.0001). Women with high compliance (58%) were motivated by: (1) the perception of improved health upon taking the tablets (treatment = 24%, control = 10%); (2) the insistence by midwives that they take the tablets; and (3) the mention that the tablets would improve health. Women with low compliance (42%) reported: (1) the experience of side-effects that they associated with the tablets (treatment = 13%, control = 14%); (2) misunderstanding that they needed to continue taking the tablets throughout pregnancy (treatment = 0%, control = 18%); and (3) forgetfulness.ConclusionCompliance with iron/folic acid supplementation in Senegal can be increased by providing women with clear instructions about tablet intake and educating them on the health benefits of the tablets.
Oxygen‐derived free radicals mediate endothelium‐dependent contractions in femoral arteries of rats with streptozotocin‐induced diabetes
Authors: Shi Y , So K‐F , Man R Y K , Vanhoutte P M 
Published: September 2007

Background and purpose:The present experiments were designed to study the contribution of oxygen‐derived free radicals to endothelium‐dependent contractions in femoral arteries of rats with streptozotocin‐induced diabetes.Experimental approach:Rings with and without endothelium were suspended in organ chambers for isometric tension recording. The production of oxygen‐derived free radicals in the endothelium was measured with 2′,7′‐dichlorodihydrofluorescein diacetate using confocal microscopy. The presence of protein was measured by western blotting.Key results:In the presence of L‐NAME, the calcium ionophore A23187 induced larger endothelium‐dependent contractions in femoral arteries from diabetic rats. Tiron, catalase, deferoxamine and MnTMPyP, but not superoxide dismutase reduced the response, suggesting that oxygen‐derived free radicals are involved in the endothelium‐dependent contraction. In the presence of L‐NAME, A23187 increased the fluorescence signal in femoral arteries from streptozotocin‐treated, but not in those from control rats, confirming that the production of oxygen‐derived free radicals contributes to the enhanced endothelium‐dependent contractions in diabetes. Exogenous H2O2 caused contractions in femoral arterial rings without endothelium which were reduced by deferoxamine, indicating that hydroxyl radicals contract vascular smooth muscle and thus could be an endothelium‐derived contracting factor in diabetes. The reduced presence of Mn‐SOD and the decreased activity of catalase in femoral arteries from streptozotocin‐treated rats demonstrated the presence of a redox abnormality in arteries from rats with diabetes.Conclusions and implications:These findings suggest that the redox abnormality resulting from diabetes increases oxidative stress which facilitates and/or causes endothelium‐dependent contractions.British Journal of Pharmacology (2007) 152, 1033–1041; doi:10.1038/sj.bjp.0707439; published online 3 September 2007
Pulmonary Toxicity of Expancel® Microspheres in the Rat
Authors: Porter Dale W. , Hubbs Ann F. , Baron Paul A. , Millecchia Lyndell L. , Wolfarth Michael G. , Battelli Lori A. , Schwegler-Berry Diane E. , Beighley Christopher M. , Andrew Michael E. , Castranova Vincent 
Published: September 2007

Expancel® microspheres are thermoplastic microspheres enclosing hydrocarbon. These microspheres expand when heated, producing many applications. Because they have unknown biological persistence and toxicity, we investigated the toxicity of two unexpanded (11.1 and 15.4 μm mean diameter) and two expanded (3.1 and 5.5 μm mass median aerodynamic diameter) Expancel® microspheres in intratracheally-instilled, male, Sprague–Dawley rats. Pulmonary histopathology was evaluated at 28 days postexposure. Bronchoalveolar lavage fluid was evaluated at days 1, 7, 14, and 28 days postexposure. Crystalline silica was the positive control. By histopathology, both unexpanded and expanded microspheres caused granulomatous bronchopneumonia characterized by macrophages and giants cells, suggesting a persistent foreign body response. Expanded, but not unexpanded microspheres, also caused eosinophilic bronchitis and bronchiolitis, mucous metaplasia of airways and organized granulomatous inflammation with associated fibrosis and frequent airway obstruction. In contrast, alveolar macrophage activation, polymorphonuclear leukocytes, LDH and albumin in bronchoalveolar laveage fluid were initially elevated but returned to near control levels at 28 days, and did not reflect the persistent granulomatous bronchopneumonia caused by Expancel® microspheres. These findings emphasize the importance of histopathology for evaluating pulmonary toxicity, suggest that Expancel® microspheres are a potential occupational hazard, and indicate a need for additional studies on their potential pulmonary toxicity. [Supplementary materials are available for this article. Go to the publisher’s online edition of Toxicology Pathology for the following free supplemental resources: motion within unexpected microspheres in H&E-stained lung (supplementary Figure 1 ); broncholar epithelium 28 days following exposure to 551 DE 20 microspheres (supplementary Figure 2 ); membrane ruffling and some instances of phagocytosis within the microspheres (supplementary Figure 3 )]
Historical population assessment of Barents Sea harp seals (Pagophilus groenlandicus)
Authors: Skaug Hans J. , Frimannslund Lennart , Øien Nils I. 
Published: September 2007

AbstractSkaug, H. J., Frimannslund, L., and Øien, N. I. 2007. Historical population assessment of Barents Sea harp seals (Pagophilus groenlandicus). – ICES Journal of Marine Science, 64: 1356–1365: –. Harp seals are an important component of the Barents Sea ecosystem. Population size is estimated to have been around 6 million seals in 1875, when large-scale exploitation by Norwegian and Russian hunters started. The estimate is obtained by fitting a population dynamics model to all available sources of data on Barents Sea harp seals, but because of a lack of information about several key parameters in the model, the uncertainty associated with the estimate is large. A sensitivity study involving three different mechanisms for density-dependence results in a range estimate of 3–7 million seals in 1875.
Estimating the defaecation rate of the African forest elephant (Loxodonta cyclotis) in Banyang‐Mbo Wildlife Sanctuary, south‐western Cameroon
Authors: Nchanji Anthony Chifu , Forboseh Philip Forbah , Powell James Arthur 
Published: September 2007

AbstractDefaecation rate is an important parameter in the conversion of dung counts to elephant numbers, yet estimates of elephant defaecation rates are available for a few sites, especially rainforest sites. The Banyang‐Mbo Wildlife Sanctuary in south‐western Cameroon is no exception in this regard. We tracked a radio‐collared herd of four forest elephants, counted their fresh droppings in two 24‐h periods each month in 36 consecutive months. Our results show a mean defaecation rate of 15.9 [95% CI (12.2–19.7)] dung piles per elephant per day. We found significant monthly and inter‐annual variation in defaecation rates with implications for their predictability and forest elephant surveys. In particular, our results show that mean defaecation rates are higher for the wettest period of the year than the relatively dry months.