bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of wireless sensors in assessing occlusal and bite forces: A systematic review
Authors: Ardila Carlos‐M. , Jiménez‐Arbeláez Gustavo A. , Vivares‐Builes Annie Marcela 
Published: April 2024

AbstractBackgroundThe noteworthy correlation between bite force and masticatory performance emphasizes its significance as a meaningful and objective method for assessing oral function. Furthermore, in the study of bruxism, the measurement of intraoral bite force assumes critical importance. Given the importance of assessing occlusal forces and bite force, this systematic review aims to assess the efficacy of wireless sensors in measuring these forces.MethodsThe search methodology employed in this systematic review adhered to the guidelines outlined by PRISMA. The strategy involved the exploration of various databases, including PubMed/MEDLINE, SCOPUS and SCIELO. An assessment tool was employed to evaluate the bias risk and study quality.ResultsThis systematic review encompassed six prospective clinical studies involving a total of 89 participants. Wireless sensors for measuring occlusal forces and bite forces were predominantly employed in healthy adults or individuals with bruxism, along with children undergoing orthodontic treatment. All wireless sensors employed in the studies underwent validation and reproducibility assessments, affirming their reliability. The findings indicated that all wireless sensors exhibited efficacy in detecting occlusal forces and bite forces.ConclusionWireless sensors offer real‐time monitoring of occlusal and bite forces, aiding in understanding force distribution and identifying bruxism patterns. Despite limited studies on their application, these sensors contribute to evolving insights. Integration into clinical practice requires careful consideration of factors like calibration and patient compliance. Ongoing research is crucial to address limitations and enhance the efficacy of wireless sensors in measuring occlusal and bite forces and managing bruxism.
A systematic review of the effectiveness of attentional bias modification to support weight management in individuals who are overweight or obese
Authors: Seage Catherine Heidi 
Published: April 2024

SummaryAttentional bias modification (ABM) is a novel cognitive‐based treatment that may help individuals reduce overeating by decreasing food processing bias and food cravings. However, most empirical studies have evaluated the short‐term effects of ABM in populations that have body mass indexes that are within healthy ranges; therefore, the extent to which this training method can influence eating behavior in individuals who are overweight or obese remains unclear. This systematic review explored the efficacy of ABM as a tool to support weight management for individuals who are overweight or obese. Ten studies met the inclusion criteria for the review. The findings reveal that although training is effective at manipulating attentional bias to food cues, there is limited evidence that training significantly impacted appetite and eating behaviors or led to maintained weight loss.
Does the Sagittal Radiographic Morphology of Subtalar Joint Affect the Alignment of Foot?
Authors: Xu Yang , Zhu Yuan , Cao Yong‐xing , Chen Gang , Xu Xiang‐yang 
Published: April 2024

ObjectivesThe etiology of flatfoot and cavus foot is multicausal and controversial. So far, no literature reports the relationship between the sagittal morphology of subtalar joint and the alignment of foot. The purpose of this study was to explore whether the subtalar alignment would influence the configuration of foot.MethodsFrom January 2017 to January 2020, we included 109 feet in the flatfoot group, 95 feet in the cavus group, and 104 feet in the control group in this retrospective comparative study. The Gissane angle and calcaneal posterior articular surface inclination angle represented the sagittal morphology of the subtalar joint. Meary's angle, calcaneal pitch angle, and talar pitch angle reflected the alignment of foot. They were measured in the weightbearing foot X‐rays. The angles in different groups were compared via Mann–Whitney U test. We calculated the correlation between the sagittal alignment of subtalar joint and the alignment of foot using Spearman's correlation analysis. Interobserver and intraobserver reliability were calculated.ResultsThe Gissane angle, calcaneal posterior articular surface inclination angle, Meary's angle, talar pitch angle, and calcaneal pitch angle were significantly different in the three groups. The Gissane angle had an excellent correlation with the Meary's angle (r = 0.850, p < 0.0001), and the talar pitch angle (r = −0.825, p < 0.0001), and a good correlation with the calcaneal pitch angle (r = 0.638, p < 0.0001). The calcaneal posterior articular surface inclination angle had an excellent correlation with the Meary's angle (r = −0.902, p < 0.001), and the talar pitch angle (r = 0.887, p < 0.0001), and a good correlation with the calcaneal pitch angle (r = −0.702, p < 0.0001). The interobserver and intraobserver reliability for all radiographic measurements was good to excellent.ConclusionA subtalar joint with a larger Gissane angle and a more horizontal calcaneal posterior articular surface angle tended to have a higher foot arch and vice versa. The inspiration from this study was that the deformities of flatfoot and cavus foot may relate to the subtalar deformity.
A novel approach to reducing hepatotoxicity related to fungal prophylaxis in pediatric lung transplant recipients
Authors: Patz‐Sobczak Caroline , Young Jennifer , Bunton Dawn , Kuklinski Cadence , Estabrook Michele 
Published: April 2024

AbstractBackgroundPediatric lung transplant patients are at risk for developing invasive fungal infections post‐transplant. No consensus exists on optimal antifungal regimens and voriconazole, a common first‐line agent, has been shown to cause hepatotoxicity. We describe a single‐center experience utilizing a novel antifungal regimen of intravenous micafungin and nebulized amphotericin B immediately post‐transplant with conversion to an azole at the time of hospital discharge and compare it to a historical cohort of patients who received voriconazole monotherapy throughout their immediate post‐operative course.MethodsThis is a retrospective review of patients in the age 0–18 who received a lung transplant from June 2016–May 2021. Data points collected included: demographic data, transplant date and discharge date, Aspergillus colonization, type of lung transplant, hospitalization and level of care information, induction and antifungal medication regimen; AST, ALT, GGT, bilirubin, and direct bilirubin at various timepoints; and respiratory and blood culture results. The two patient groups were compared by assessment of changes in LFTs and culture results.ResultsForty‐two patients were included in the analysis, with 24 patients receiving micafungin and nebulized amphotericin and 18 patients receiving voriconazole. All patients in both groups experienced a post‐operative elevation in at least one transaminase or bilirubin. More patients in the micafungin/amphotericin group had resolution of all abnormal LFTs by 1 month post‐transplant (p = .036). Additionally, patients in the micafungin/amphotericin group experienced faster normalization of their LFTs compared with the voriconazole group (p < .001). Ten patients in the micafungin/amphotericin group and five patients in the voriconazole group were found to have fungal growth on culture post‐transplant, but this difference was not found to be statistically significant (p = .507).ConclusionsAn antifungal regimen of micafungin and nebulized amphotericin B liposomal may be useful at decreasing the duration of elevated liver enzymes in pediatric patients in the immediate post‐lung transplant period when compared with voriconazole monotherapy. Larger prospective studies looking at antifungal regimens in pediatric patients post‐lung transplant are warranted.
Electrical stimulation of the lower eyelid orbicularis oculi muscle improves periocular dark circles
Authors: Yasui Yukiko , Kato Hiroshi , Ogura Shuntaro , Kimura Masayo , Kato Aki , Hirano Yoshio , Morita Hiroshi , Yasukawa Tsutomu , Kurachi Ako , Takeda Soshi , Morita Akimichi 
Published: April 2024

AbstractBackgroundWe developed and tested the safety and efficacy of a cosmetic device to improve dark circles using electrical muscle stimulation of the orbicularis oculi muscle.MethodsOverall, 18 participants (36 eyes) were studied. The following five items were evaluated before and after the intervention:(1) the Clinical Dark Circle Score using clinical findings and photographs, (2) transcutaneous oxygen partial pressure (TcPO2) on the lower eyelid, (3) thermography, (4) two‐dimensional laser blood flowmetry, and (5) spectrophotometry.ResultsThe mean score at baseline was 2.0 ± 0.90 (mean ± standard deviation), and that at the end of the study was 1.2 ± 1.0 (Wilcoxon signed‐rank sum test, p < 0.0001), indicating a significant reduction. The spectrophotometer showed a significant decrease in a* and L* values before and after use (Wilcoxon signed‐rank sum test, p < 0.0001). There was also a weak negative correlation between the change in score and the change in blood flow and TcPO2 measured using a laser perfusion device (Spearman's rank correlation coefficient, r = –0.32 and –0.39, respectively). Stratified analysis of the baseline score showed a strong negative correlation between the change in score and the change in spectrophotometric a* in the subjects/group with mild periocular dark circles (Spearman's rank correlation coefficient, r = –0.46). Contrastingly, no correlation was observed for any of the measurements in the subjects/group with severe periocular dark circles. After 1 month, no device‐related ophthalmic adverse events were observed in any of the participants.ConclusionElectrical muscle stimulation could improve periocular dark circles, especially in the subjects/group with mild periocular dark circles, and was safe.
Effects on keratinocytes of the traditional combination of herb extract (Royal Oji Complex) implicated the improvement of young children's skin moisture and barrier
Authors: Trinh Thuy‐Tien Thi , Choi Jae Hee , Yang Jee‐Eun , Kim Woon Ha , Chien Pham Ngoc , Le Linh Thi Thuy , Ngan‐Giang Nguyen , Nga Pham Thi , Nam Sun‐Young , Heo Chan‐Yeong 
Published: April 2024

AbstractBackgroundNatural products are often friendly and can be used on children's skin after systematic and careful research. Therefore, in this study, the Royal Oji Complex (ROC), a product with natural ingredients, was used to study their effectiveness on keratinocytes taken from the skin of children from 0 to 3 years old.MethodNormal human epidermal keratinocytes and tissue‐isolated keratinocytes (TIKC) from young donors were treated with three different concentrations of ROC: 0.1, 1, and 10 ppm. The mRNA expression of the epidermal barrier's essential genes, such as hyaluronic acid synthase 3 (Has3), involucrin (IVL), loricrin (LOR), and claudin‐1 (CLD1) was investigated using qRT‐PCR. Ceramide content was measured by ELISA, with retinoic acid (R.A.) and amarogentin (AMA) serving as positive controls.ResultsROC significantly elevated HAS3 gene expression in HEKn cells, especially at 10 ppm, indicating potential advantages for skin hydration in young infants. IVL increased at first but decreased as ROC concentrations increased. LOR was upregulated at lower ROC concentrations but reduced at higher doses. CLD1 gene expression increased considerably in HEKn but reduced with increasing ROC doses. Ceramide concentration increased somewhat but not significantly at 10 ppm.ConclusionROC shows potential in altering keratinocyte gene expression, with unique responses in HEKn and TIKC from young donors. While changes in ceramide content were insignificant, these results help to comprehend ROC's multiple effects on young children's skin.
Monopole Floer homology and invariant theta characteristics
Authors: Lin Francesco 
Published: April 2024

AbstractWe describe a relationship between the monopole Floer homology of three‐manifolds and the geometry of Riemann surfaces. For an automorphism of a compact Riemann surface with quotient , there is a natural correspondence between theta characteristics on which are invariant under and self‐conjugate structures on the mapping torus of . We show that the monopole Floer homology groups of are explicitly determined by the eigenvalues of the (lift of the) action of on , the space of holomorphic sections of , and discuss several consequences of this description. Our result is based on a detailed analysis of the transversality properties of the Seiberg–Witten equations for suitable small perturbations.
Aerodynamic Performance Evaluation of a Coaxial Octocopter Based on Taguchi Method
Authors: Geydirici Evren , Derman Kuzey C. , Cadirci Sertac 
Published: April 2024

Abstract
The design and optimization of propellers for unmanned aerial vehicles (UAVs) are essential for optimal performance and high efficiency. This study presents a numerical investigation of the aerodynamic performance of coaxial octocopters using openfoam as flow solver. While the aerodynamic performance is affected by many parameters, the current study focuses on four main parameters: the propeller type, the horizontal and vertical separation distances between the propellers, and the ratio between the rotational speeds of the upper propeller and the lower one. To find the minimum number of simulations to be performed within defined limits, and reduce the number of computational fluid dynamics (CFD) simulations that cause high computational cost, Taguchi method was employed. In this study, average thrusts were calculated for the preliminary design of the octocopter by examining an isolated single propeller and dual- and quad propellers taking their rotation directions into account. The Taguchi design matrix revealed that for all cases investigated, the propeller type is the most dominant design parameter followed by the velocity ratio of the upper propeller to the lower one (nU/nL) and vertical (z/D) and horizontal (ℓ/D) orientation of coaxial propellers. However, it was shown that ℓ/D and z/D may play a significant role in vortex formation and pressure fluctuations which should be considered as design criteria for coaxial octocopters associated with flow attributes. The results showed that the aerodynamic performance parameters are not dependent on all the selected parameters, and demonstrated that the selected propeller designs improved aerodynamic performance.
Capturing Local Temperature Evolution During Additive Manufacturing Through Fourier Neural Operators
Authors: Chen Jiangce , Xu Wenzhuo , Baldwin Martha , Nijhuis Björn , den Boogaard Ton van , Grande Gutiérrez Noelia , Prabha Narra Sneha , McComb Christopher 
Published: April 2024

Abstract
High-fidelity, data-driven models that can quickly simulate thermal behavior during additive manufacturing (AM) are crucial for improving the performance of AM technologies in multiple areas, such as part design, process planning, monitoring, and control. However, complexities of part geometries make it challenging for current models to maintain high accuracy across a wide range of geometries. In addition, many models report a low mean-square error (MSE) across the entire domain of a part. However, in each time-step, most areas of the domain do not experience significant changes in temperature, except for the regions near recent depositions. Therefore, the MSE-based fidelity measurement of the models may be overestimated. This article presents a data-driven model that uses the Fourier neural operator to capture the local temperature evolution during the AM process. Besides MSE, the model is also evaluated using the R2 metric, which places great weight on the regions where the temperature changes significantly than MSE. The model was trained and tested on numerical simulations based on the discontinuous Galerkin finite element method for the direct energy deposition AM process. The results shows that the model maintains 0.983−0.999 R2 over geometries not included in the training data, which is higher than convolutional neural networks and graph convolutional neural networks we implemented, the two widely used architectures in data-driven predictive modeling.
Do Parental Beliefs and Support Predict the Motor Competence of Youth With Visual Impairments?
Authors: Stribing Alexandra , Gilbert Emily N. , Lieberman Lauren J. , Brian Ali 
Published: April 2024

Parents tend to play a vital role in their child’s motor competence for youth with visual impairments. However, little research has explored parental mindsets and support (e.g., transportation) surrounding their child’s motor skills and how it may predict motor competence. The purpose of this study was to examine the extent to which parents’ mindset items along with parental support may predict their children’s actual motor competence. Parents of youth with visual impairments (N = 92; mothers = 69.5%, fathers = 18.1%; Mage = 42.91 years, SD = 8.08 years) completed the modified parents’ perception questionnaire. Youth with visual impairments ages 9–19 years (N = 95; Mage = 153.35 months, SD = 27.58 months, girls = 37.1%, boys = 53.3%, 9.6% missing) completed the Test of Gross Motor Development-third edition. Results from a backward linear regression convey parental beliefs (i.e., growth mindsets) and support variables (e.g., providing transportation) significantly predicted their child’s actual motor competence, F(6, 84) = 9.77, p < .001, adj. R2 = .37. Results could inform parents on their importance toward supporting and believing in developing their child’s motor competence.
Combination of ganciclovir and trifluridine prevents drug-resistance emergence in HSV-1
Authors: Schalkwijk Hanna Helena , Shewakramani Neesha Rajesh , Das Kalyan , Andrei Graciela , Snoeck Robert 
Published: April 2024

ABSTRACT

Ocular herpes simplex virus 1 (HSV-1) infections can lead to visual impairment. Long-term acyclovir (ACV) prophylaxis reduces the frequency of recurrences but is associated with drug resistance. Novel therapies are needed to treat drug-resistant HSV-1 infections. Here, we describe the effects of trifluridine (TFT) in combination with ACV or ganciclovir (GCV) on HSV-1 replication and drug-resistance emergence. Wild-type HSV-1 was grown under increasing doses of one antiviral (ACV, GCV, or TFT) or combinations thereof (ACV + TFT or GCV + TFT). Virus cultures were analyzed by Sanger sequencing and deep sequencing of the
UL23
[thymidine kinase (TK)] and
UL30
[DNA polymerase (DP)] genes. The phenotypes of novel mutations were determined by cytopathic effect reduction assays. TFT showed overall additive anti-HSV-1 activity with ACV and GCV. Five passages under ACV, GCV, or TFT drug pressure gave rise to resistance mutations, primarily in the TK. ACV + TFT and GCV + TFT combinatory pressure induced mutations in the TK and DP. The DP mutations were mainly located in terminal regions, outside segments that typically carry resistance mutations. TK mutations (R163H, A167T, and M231I) conferring resistance to all three nucleoside analogs (ACV, TFT, and GCV) emerged under ACV, TFT, ACV + TFT pressure and under GCV + TFT pressure initiated from suboptimal drug concentrations. However, higher doses of GCV and TFT prevented drug resistance in the resistance selection experiments. In summary, we identified novel mutations conferring resistance to nucleoside analogs, including TFT, and proposed that GCV + TFT combination therapy may be an effective strategy to prevent the development of drug resistance.
Functional analysis, diversity, and distribution of the
ean
cluster responsible for 17
β
-estradiol degradation in sphingomonads
Authors: Zhang Mingliang , Gao Siyuan , Pan Kaihua , Liu Hongfei , Li Qian , Bai Xuekun , Zhu Qian , Chen Zeyou , Yan Xin , Hong Qing 
Published: April 2024

ABSTRACT

17
β
-estradiol (E2) is a natural endocrine disruptor that is frequently detected in surface and groundwater sources, thereby threatening ecosystems and human health. The newly isolated E2-degrading strain
Sphingomonas colocasiae
C3-2 can degrade E2 through both the 4,5-seco pathway and the 9,10-seco pathway; the former is the primary pathway supporting the growth of this strain and the latter is a branching pathway. The novel gene cluster
ean
was found to be responsible for E2 degradation through the 4,5-seco pathway, where E2 is converted to estrone (E1) by EanA, which belongs to the short-chain dehydrogenases/reductases (SDR) superfamily. A three-component oxygenase system (including the P450 monooxygenase EanB1, the small iron-sulfur protein ferredoxin EanB2, and the ferredoxin reductase EanB3) was responsible for hydroxylating E1 to 4-hydroxyestrone (4-OH-E1). The enzymatic assay showed that the proportion of the three components is critical for its function. The dioxygenase EanC catalyzes ring A cleavage of 4-OH-E1, and the oxidoreductase EanD is responsible for the decarboxylation of the ring A-cleavage product of 4-OH-E1. EanR, a TetR family transcriptional regulator, acts as a transcriptional repressor of the
ean
cluster. The
ean
cluster was also found in other reported E2-degrading sphingomonads. In addition, the novel two-component monooxygenase EanE1E2 can open ring B of 4-OH-E1
via
the 9,10-seco pathway, but its encoding genes are not located within the
ean
cluster. These results refine research on genes involved in E2 degradation and enrich the understanding of the cleavages of ring A and ring B of E2.

IMPORTANCE

Steroid estrogens have been detected in diverse environments, ranging from oceans and rivers to soils and groundwater, posing serious risks to both human health and ecological safety. The United States National Toxicology Program and the World Health Organization have both classified estrogens as Group 1 carcinogens. Several model organisms (proteobacteria) have established the 4,5-seco pathway for estrogen degradation. In this study, the newly isolated
Sphingomonas colocasiae
C3-2 could degrade E2 through both the 4,5-seco pathway and the 9,10-seco pathway. The novel gene cluster
ean
(including
eanA
,
eanB1
,
eanC
, and
eanD
) responsible for E2 degradation by the 4,5-seco pathway was identified; the novel two-component monooxygenase EanE1E2 can open ring B of 4-OH-E1 through the 9,10-seco pathway. The TetR family transcriptional regulator EanR acts as a transcriptional repressor of the
ean
cluster. The cluster
ean
was also found to be present in other reported E2-degrading sphingomonads, indicating the ubiquity of the E2 metabolism in the environment.