bluuebunny/crossref_metadata_2025_split huggingface dataset:
International safety assessment of pesticides: Dithiocarbamate pesticides, ETU, and PTU—A review and update
Authors: Vettorazzi Gaston , Almeida Waldemar F. , Burin Gerry J. , Jaeger Robert B. , Puga Flavio R. , Rahde Alberto F. , Reyes Felix G. , Schvartsman S. 
Published: February 2006

AbstractFor the last 30 years the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) has carried out toxicological evaluations and safety assessments of dithiocarbamate pesticides, continuously adjusting previous appraisals in the light of new data and advances in the understanding of the principles and mechanisms of toxic action of these compounds. The historical narrative of the evaluative process is followed by an account of the present international safety assessment status of the dithiocarbamate pesticides so far examined by the JMPR. They are ferbam, mancozeb, maneb, metiram, nabam, propineb, thiram, zineb, ziram, and the associated substances, ethylenethiourea (ETU) and propylenethiourea (PTU). © 1996 Wiley‐Liss, Inc.
Molecular taxonomy of the yeasts
Authors: Kurtzman Cletus P. 
Published: February 2006

AbstractThe term ‘yeast’ is often taken as a synonym for Saccharomyces cerevisiae, but the phylogenetic diversity of yeasts is illustrated by their assignment to two taxonomic classes of fungi, the ascomycetes and the basidiomycetes. Subdivision of taxa within their respective classes is usually made from comparisons of morphological and physiological features whose genetic basis is often unknown. Application of molecular comparisons to questions in yeast classification offers an unprecedented opportunity to re‐evaluate current taxonomic schemes from the perspective of quantitative genetic differences. This review examines the impact of molecular comparisons, notably rRNA/rDNA sequence divergence, on the current phenotypically defined classification of yeasts. Principal findings include: 1) budding ascomycetous yeasts are monophyletic and represent a sister group to the filamentous ascomycetes, 2) fission yeasts are ancestral to budding and filamentous ascomycetes, 3) the molecular phylogeny of basidiomycetous yeasts is generally congruent with type of hyphal septum, presence or absence of teliospores in the sexual state, and occurrence of cellular xylose.
A new definition of viscosity solutions for a class of second-order degenerate elliptic integro-differential equations
Authors: Arisawa Mariko 
Published: February 2006

We present a new definition of the viscosity solution for a class of integro-differential equations in a bounded open domain

Ω

in

\mathbf{R}^{N}

. We consider either the Dirichlet boundary condition or the Neumann boundary condition on the boundary. These equations correspond to the process which is a combination of the jumps and the Brownian motion. We give the comparison and the existence results for the viscosity solution in our new framework.

Résumé

Nous présentons une nouvelle définition de la solution de viscosité pour certaine classe des équations intégro-différentielles sur un ouvert borné dans

\mathbf{R}^{N}

. Sur le bord, on considère soit la condition de Dirichlet ou soit la condition de Neumann. Ces équations correspondent au processus de la combinaison des sauts et du mouvement brownien. Nous donnons des résultats de la comparaison et de l'existence de la solution de viscosité dans notre cadre.
Planar binary trees and perturbative calculus of observables in classical field theory
Authors: Harrivel Dikanaina 
Published: February 2006

We study the Klein–Gordon equation coupled with an interaction term

(□ + m^{2})\phi + \lambda \phi ^{p} = 0

. In the linear case (

\lambda = 0

) a kind of generalized Noether's theorem gives us a conserved quantity. The purpose of this paper is to find an analogue of this conserved quantity in the interacting case. We will see that we can do this perturbatively, and we define explicitly a conserved quantity, using a perturbative expansion based on Planar Trees and a kind of Feynman rule. Only the case

p = 2

is treated but our approach can be generalized to any

\phi ^{p}

-theory.

Résumé

Nous étudions l'équation de Klein–Gordon couplée avec un terme d'interaction

(□ + m^{2})\phi + \lambda \phi ^{p} = 0

. Dans le cas où l'équation est linéaire (

\lambda = 0

), une généralisation du théorème de Noether nous donne une quantité conservée. Le but de cet article est de trouver un analogue de cette quantité dans le cas non-linéaire (

\lambda \neq 0

). Nous verrons que pour

λ

petit, on peut définir explicitement une quantité conservée en utilisant un développement perturbatif basé sur les Arbres Plans et des règles de Feynman particulières. Seul le cas

p = 2

est traité mais notre approche peut être appliquée pour tout

p \geq 2

.
Holocene variations in the Asian monsoon inferred from the geochemistry of lake sediments in central Tibet
Authors: Morrill Carrie , Overpeck Jonathan T. , Cole Julia E. , Liu Kam-biu , Shen Caiming , Tang Lingyu 
Published: February 2006

AbstractWe present a record of monsoon variations for the early and middle Holocene that is inferred from the geochemistry of sediment cores from Ahung Co, a lake in central Tibet. The resolution of this record is better than 50 yr and the age model is derived from radiocarbon ages of terrestrial charcoal, which eliminates errors associated with the lake hard-water effect. We made down-core geochemical measurements of % carbonate, % organic carbon, C/N and δ13C of bulk organic matter, δ13C and δ18O of carbonate, and % dolomite. Proxy calibration and modern water-balance reconstruction show that these are proxies for lake depth and the amount of monsoon precipitation. We find that lake level and monsoon precipitation have been decreasing at Ahung Co since the early Holocene (∼7500 cal yr B.P.). Superimposed on this trend are rapid declines in monsoon rainfall at 7000–7500 and 4700 cal yr B.P. and seven century-scale wet–dry oscillations. The cores do not contain sediment from the last ∼4000 yr. Surface sediments from the lake accumulated during the 20th century, however. From this, we argue that lake levels have risen again recently following a late Holocene dry period.
Holocene vegetation change in the northern Peten and its implications for Maya Prehistory
Authors: Wahl David , Byrne Roger , Schreiner Thomas , Hansen Richard 
Published: February 2006

AbstractAn ∼8400 cal yr record of vegetation change from the northern Peten, Guatemala, provides new insights into the environmental history of the archaeological area known as the Mirador Basin. Pollen, loss on ignition, and magnetic susceptibility analyses indicate warm and humid conditions in the early to mid-Holocene. Evidence for a decrease in forest cover around 4600 cal yr B.P. coincides with the first appearance ofZea mayspollen, suggesting that human activity was responsible. The period between 3450 cal yr B.P. and 1000 cal yr B.P. is characterized by a further decline in forest pollen types, includes an abrupt increase in weedy taxa, and exhibits the highest magnetic susceptibility values since the early Holocene, all of which suggest further agricultural disturbance in the watershed. A brief drop in disturbance indicators around 1800 cal yr B.P. may represent the Preclassic abandonment of the area. Changing pollen frequencies around 1000 cal yr B.P. indicate a cessation of human disturbance, which represents the Late Classic collapse of the southern Maya lowlands.
Should Quaternary sea-level changes be used to correct glacier ELAS, vegetation belt altitudes and sea level temperatures for inferring climate changes?
Authors: Osmaston Henry A. 
Published: February 2006

AbstractChanges in the altitudes of glacier snowlines (ELAs) and the altitudes of montane vegetation belts (VBAs) measure Quaternary climatic change. An accepted ‘correction’ to such changes by deducting the amount of contemporary sea level fall is wrong, since the air displaced by the ice sheets approximately fills the space left by the falling sea level and so there is no overall downward movement of the troposphere. This also causes a reduced cooling at the lowered sea level relative to that at the former inter-glacial sea level, about 1°C at the Las Glacial Maximum, which reduces the discrepancies previously noted by others between terrestrial and marine estimates of sea-level cooling. The change in temperature is indicated by the product of the ELA or VBA lowering and the environmental lapse rate (ELR). Prior estimates of ΔELA (−900 ± 135 m) and ELR (−6° ± 0.1°C km−1) would indicate a cooling of −5.4°C at interglacial sea level and −4.4°C at glacial sea level, although glacial-period ELRs are not known reliably. Established ELA corrections for local epeirogenic uplift or subsidence are appropriate.
Work-related stressors, depression and quality of life in Danish managers
Authors: Bech P. , Andersen M.B. , Bech-Andersen G. , Tønnesen S. , Agnarsdottir E. , Borg V. 
Published: February 2006

AbstractBackgroundBy use of valid questionnaires to investigate work-related stress and distress in Danish managers.MethodsThe survey focused on members of the Danish Association of Managers and Executives who no longer were active (formermanagers' group). Acting managers (active managers' group) served as controls. Questionnaires measuring stressors at work and general life events were used. For the measurement of distress, scales for depression and quality of life were used.ResultsThe Mokken analysis proved the validity of the questionnaires, i.e. their summed-up total scores were sufficient statistics. No differences were found between former (n= 1256) and active managers (n= 942) as to life events. Approximately 20% of former managers were at risk of depression and 12% had developed major depression. Among the specific work-related stressors were role overload, lack of team spirit and lack of social support. The percentage of active managers at risk of or suffering from major depression did not differ significantly from the Danish general population. Approximately 37% of the former managers had a decreased well-being. Alcohol use was found to be significantly associated with depression.ConclusionsThe study identified specific work-related stressors in managers, 12% of whom developed a major depression.
What a psychiatrist needs to know about diabetes
Authors: Charbonnel B. 
Published: February 2006

AbstractDiabetes mellitus is a complex metabolic disorder, caused by defects in insulin action and/or insulin production and is defined as afasting hyperglycaemia of >126 mg/dl, with normoglycaemia being ≥70 and ≤ 110 mg/dl. There are two main types of diabetes. Type 1 diabetes (around 10% of cases) is an autoimmune disease, usually of early onset, in which pancreatic islet beta cells that secrete insulin are destroyed. Type 2 diabetes (around 85% of cases) is characterised principally by insulin resistance and impaired insulin secretion. Heredity and obesity are major risk factors for Type 2 diabetes. Diabetes is associated with potentially life-threatening microvascular and macrovascular complications caused by elevated serum glucose levels. Treatment of diabetes aims at restoring glycaemic control. In Type 1 diabetes, this can be achieved by injecting insulin. Oral hypoglycaemic medications that stimulate insulin secretion and/or modify glucose metabolism can be used as a first-line treatment in Type 2 diabetes mellitus. However, insulin is usually necessary in later phases of the disease. Lifestyle changes, such as diet and exercise, are also important. Glycaemic control can be measured by fasting blood glucose levels and also by glycosylated haemoglobin levels. The latter measure gives an indication of glycaemic control over a period of three months, and a reduction in glycosylated haemoglobin is the most appropriate treatment goal in the management of diabetes.
Data on diabetes from the French cohort study in schizophrenia
Authors: Philippe A. , Vaiva G. , Casadebaig F. 
Published: February 2006

AbstractTo establish the impact of antipsychotic medication on the incidence of diabetes, we have analysed data from the prospective French Cohort study of mortality in schizophrenia. This generated a large database of 3470 patients with schizophrenia initially enrolled in 1993 for which data collection on comorbidity has been collected systematically every three years since. The primary objective of the study was to evaluate the mortality rate in the study cohort. From this database, the prevalence and incidence of diabetes can be studied. In 1993, nine patients in 10 were prescribed conventional antipsychotics and the remainder amisulpride and clozapine. Since the introduction of risperidone and olanzapine, atypical antipsychotics are now used in one-third of patients. Multiple antipsychotic medications are used in many patients, with the exception of those receiving clozapine. At inclusion, 2.2% of patients in the study cohort had a diagnosis of diabetes. Morbidity rates were higher in females than in males (3.4% and 1.6%, respectively) and it was only in females that the standard morbidity ratio with respect to the general population was significantly elevated (2.2; 95% confidence intervals: 1.6 and 2.9). The prevalence of diabetes in the study cohort rose over the course of the study. Multivariate regression analysis was performed in order to identify potential determinants of diabetes. For pre-existing diabetes, four factors were identified: age at first hospitalisation, age, obesity and duration of schizophrenia. The same factors with the exception of length of illness were identified for the incident cases. There was no evidence for an interaction between the class and type of antipsychotic medication and risk of treatment emergent diabetes. However, the use of multiple antipsychotic treatments makes the individualisation of specific risks associated with any other antipsychotic drug impossible.
siRecords: an extensive database of mammalian siRNAs with efficacy ratings
Authors: Ren Yongliang , Gong Wuming , Xu Qiqi , Zheng Xin , Lin Dong , Wang Yejun , Li Tongbin 
Published: January 2006

Abstract
Summary: Short interfering RNAs (siRNAs) have been gaining popularity as the gene knock-down tool of choice by many researchers because of the clean nature of their workings as well as the technical simplicity and cost efficiency in their applications. We have constructed siRecords, a database of siRNAs experimentally tested by researchers with consistent efficacy ratings. This database will help siRNA researchers develop more reliable siRNA design rules; in the mean time, siRecords will benefit experimental researchers directly by providing them with information about the siRNAs that have been experimentally tested against the genes of their interest. Currently, more than 4100 carefully annotated siRNA sequences obtained from more than 1200 published siRNA studies are hosted in siRecords. This database will continue to expand as more experimentally tested siRNAs are published.
Availability: The siRecords database can be accessed at
Contact: toli@biocompute.umn.edu
Dimethylallyl Diphosphate and Geranyl Diphosphate Pools of Plant Species Characterized by Different Isoprenoid Emissions
Authors: Nogués Isabel , Brilli Federico , Loreto Francesco 
Published: February 2006

Abstract
Dimethylallyl diphosphate (DMADP) and geranyl diphosphate (GDP) are the last precursors of isoprene and monoterpenes emitted by leaves, respectively. DMADP and GDP pools were measured in leaves of plants emitting isoprene (Populus alba), monoterpenes (Quercus ilex and Mentha piperita), or nonemitting isoprenoids (Prunus persica). Detectable pools were found in all plant species, but P. persica showed the lowest pool size, which indicates a limitation of the whole pathway leading to isoprenoid biosynthesis in nonemitting species. The pools of DMADP and GDP of nonemitting, isoprene-emitting, and monoterpene-emitting species were partially labeled (generally 40%–60% of total carbon-incorporated 13C) within the same time by which volatile isoprenoids are fully labeled (15 min). This indicates the coexistence of two pools for both precursors, the rapidly labeled pool presumably occurring in chloroplasts and thereby synthesized by the methylerythritol phosphate pathway and the nonlabeled pool presumably located in the cytosol and synthesized by the mevalonic pathway. In M. piperita storing monoterpenes in specialized leaf structures, the GDP pool remained totally unlabeled, indicating either that monoterpenes are totally formed by the mevalonic pathway or that labeling occurs slowly in comparison to the large pool of stored monoterpenes in this plant. The pools of DMADP and GDP increased during the season (from May to July) but decreased when the leaf was darkened or exposed to very high temperature. In the dark, the pool of DMADP of the isoprene-emitting species decreased faster than the pool of GDP. However, after 6 h of darkness, both pools were depleted to about 10% of the pool size in illuminated leaves. This indicates that both the chloroplastic and the cytosolic pools of precursors are depleted in the dark. When comparing measurements over the season and at different temperatures, an inverse correlation was observed between isoprene emission by P. alba and the DMADP pool size and between monoterpene emission by Q. ilex and the GDP pool size. This suggests that the pool size does not limit the emission of isoprenoids. Rather, it indicates that the flux of volatile isoprenoids effectively controls the size of their pools of precursors.
Comparative Analysis of the Heat Stable Proteome of Radicles of Medicago truncatula Seeds during Germination Identifies Late Embryogenesis Abundant Proteins Associated with Desiccation Tolerance
Authors: Boudet Julie , Buitink Julia , Hoekstra Folkert A. , Rogniaux Hélène , Larré Colette , Satour Pascale , Leprince Olivier 
Published: February 2006

Abstract
A proteomic analysis was performed on the heat stable protein fraction of imbibed radicles of Medicago truncatula seeds to investigate whether proteins can be identified that are specifically linked to desiccation tolerance (DT). Radicles were compared before and after emergence (2.8 mm long) in association with the loss of DT, and after reinduction of DT by an osmotic treatment. To separate proteins induced by the osmotic treatment from those linked with DT, the comparison was extended to 5 mm long emerged radicles for which DT could no longer be reinduced, albeit that drought tolerance was increased. The abundance of 15 polypeptides was linked with DT, out of which 11 were identified as late embryogenesis abundant proteins from different groups: MtEm6 (group 1), one isoform of DHN3 (dehydrins), MtPM25 (group 5), and three members of group 3 (MP2, an isoform of PM18, and all the isoforms of SBP65). In silico analysis revealed that their expression is likely seed specific, except for DHN3. Other isoforms of DNH3 and PM18 as well as three isoforms of the dehydrin Budcar5 were associated with drought tolerance. Changes in the abundance of MtEm6 and MtPM25 in imbibed cotyledons during the loss of DT and in developing embryos during the acquisition of DT confirmed the link of these two proteins with DT. Fourier transform infrared spectroscopy revealed that the recombinant MtPM25 and MtEm6 exhibited a certain degree of order in the hydrated state, but that they became more structured by adopting α helices and β sheets during drying. A model is presented in which DT-linked late embryogenesis abundant proteins might exert different protective functions at high and low hydration levels.
AtATM3 Is Involved in Heavy Metal Resistance in Arabidopsis
Authors: Kim Do-Young , Bovet Lucien , Kushnir Sergei , Noh Eun Woon , Martinoia Enrico , Lee Youngsook 
Published: February 2006

Abstract
AtATM3, an ATP-binding cassette transporter of Arabidopsis (Arabidopsis thaliana), is a mitochondrial protein involved in the biogenesis of iron-sulfur clusters and iron homeostasis in plants. Our gene expression analysis showed that AtATM3 is up-regulated in roots of plants treated with cadmium [Cd(II)] or lead (II); hence, we investigated whether this gene is involved in heavy metal tolerance. We found that AtATM3-overexpressing plants were enhanced in resistance to Cd, whereas atatm3 mutant plants were more sensitive to Cd than their wild-type controls. Moreover, atatm3 mutant plants expressing 35S promoter-driven AtATM3 were more resistant to Cd than wild-type plants. Since previous reports often showed that the cytosolic glutathione level is positively correlated with heavy metal resistance, we measured nonprotein thiols (NPSH) in these mutant plants. Surprisingly, we found that atatm3 contained more NPSH than the wild type under normal conditions. AtATM3-overexpressing plants did not differ under normal conditions, but contained less NPSH than wild-type plants when exposed to Cd(II). These results suggest a role for AtATM3 in regulating cellular NPSH level, a hypothesis that was further supported by our gene expression study. Genetic or pharmacological inhibition of glutathione biosynthesis led to the elevated expression of AtATM3, whereas expression of the glutathione synthase gene GSH1 was increased under Cd(II) stress and in the atatm3 mutant. Because the closest homolog of AtATM3 in fission yeast (Schizosaccharomyces pombe), HMT1, is a vacuolar membrane-localized phytochelatin-Cd transporter, it is tempting to speculate that glutathione-Cd(II) complexes formed in the mitochondria are exported by AtATM3. In conclusion, our data show that AtATM3 contributes to Cd resistance and suggest that it may mediate transport of glutamine synthetase-conjugated Cd(II) across the mitochondrial membrane.
High-Resolution Single-Copy Gene Fluorescence in Situ Hybridization and Its Use in the Construction of a Cytogenetic Map of Maize Chromosome 9
Authors: Wang Chung-Ju Rachel , Harper Lisa , Cande W. Zacheus 
Published: February 2006

AbstractHigh-resolution cytogenetic maps provide important biological information on genome organization and function, as they correlate genetic distance with cytological structures, and are an invaluable complement to physical sequence data. The most direct way to generate a cytogenetic map is to localize genetically mapped genes onto chromosomes by fluorescence in situ hybridization (FISH). Detection of single-copy genes on plant chromosomes has been difficult. In this study, we developed a squash FISH procedure allowing successful detection of single-copy genes on maize (Zea mays) pachytene chromosomes. Using this method, the shortest probe that can be detected is 3.1 kb, and two sequences separated by ∼100 kb can be resolved. To show the robust nature of this protocol, we localized nine genetically mapped single-copy genes on chromosome 9 in one FISH experiment. Integration of existing information from genetic maps and the BAC contig-based physical map with the cytological structure of chromosome 9 provides a comprehensive cross-referenced cytogenetic map and shows the dramatic reduction of recombination in the pericentromeric heterochromatic region. To establish a feasible mapping system for maize, we also developed a probe cocktail for unambiguous identification of the 10 maize pachytene chromosomes. These results provide a starting point toward constructing a high-resolution integrated cytogenetic map of maize.