bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross‐shift peak expiratory flow changes are unassociated with respirable coal dust exposure among South African coal miners
Authors: Naidoo Rajen N. , Robins Thomas G. , Becklake Margaret , Seixas Noah , Thompson Mary Lou 
Published: October 2007

AbstractBackgroundThe objectives of this study were to determine whether cross‐shift changes in peak expiratory flow rate (PEFR) were related to respirable dust exposure in South African coalminers.MethodsFifty workers were randomly selected from a cohort of 684 miners from 3 bituminous coalmines in Mpumalanga, South Africa. Peak expiratory efforts were measured prior to the commencement of the shift, and at the end of the shift on at least two occasions separated by at least 2 weeks, with full shift personal dust sampling being conducted on each occasion for each participant. Interviews were conducted, work histories were obtained and cumulative exposure estimates were constructed. Regression models examined the associations of cross‐shift changes in PEFR with current and cumulative exposure, controlling for shift, smoking and past history of tuberculosis.ResultsThere were marginal differences in cross‐shift PEFR (ranging from 0.1 to 2 L/min). Linear regression analyses showed no association between cross‐shift change in PEFR and current or cumulative exposure. The specific shift worked by participants in the study showed no effect.ConclusionsOur study showed no association between current respirable dust exposure and cross‐shift changes in PEFR. There was a non‐significant protective effect of cumulative dust exposure on the outcome, suggesting the presence of a “healthy worker survivor effect” in this data. Am. J. Ind. Med. 50:992–998, 2007. © 2007 Wiley‐Liss, Inc.
From lead to manganese through mercury: Mythology, science, and lessons for prevention
Authors: Alessio Lorenzo , Campagna Marcello , Lucchini Roberto 
Published: October 2007

AbstractBackgroundLead (Pb), mercury (Hg), and manganese (Mn) are well‐known neurotoxic metals. The knowledge of toxicity was developed through an extensive amount of research, starting with lead and mercury and proceeding today with manganese. Unfortunately, the consequent implementation of preventive measures was generally delayed, causing important negative effects to the exposed populations.MethodsA review and historical reconstruction of the research development that yielded modern understanding of lead and mercury neurotoxicity was conducted to derive useful lessons for the prevention of manganese neurotoxicity.ResultsMedieval alchemists named planets and metals from gods since they were already aware of the toxicity and the adverse effects caused by lead and mercury. Historical lessons learned from these two metals may help to avoid the repetition of further mistakes regarding other neurotoxic metals like manganese. The knowledge and experience on the toxicokinetics and toxikodinamics of lead and mercury is useful and valuable to identify a proper approach to “safe” exposure levels for manganese.ConclusionsFurther information is still needed on the early neurotoxic and neurobehavioral effects after prolonged exposure to very low doses of lead, mercury, and manganese. Nevertheless, according to the precautionary principle, effective preventive measures should be already undertaken to prevent the onset of more severe health effects in the population. This is the most important lesson to be learned and applied from more than 30 years of occupational and environmental neurotoxicology of metals. Am. J. Ind. Med. 50:779–787, 2007. © 2007 Wiley‐Liss, Inc.
ADH7 variation modulates extraversion and conscientiousness in substance‐dependent subjects
Authors: Luo Xingguang , Kranzler Henry R. , Zuo Lingjun , Zhang Huiping , Wang Shuang , Gelernter Joel 
Published: October 2007

AbstractHuman personality traits have been closely linked to substance dependence (SD), and are partially genetically determined. Recently, associations between alcohol dehydrogenase 7 (ADH7) and SD have been reported, which led us to investigate the relationship between ADH7 variation and personality traits. We assessed dimensions of the five‐factor model of personality and genotyped 4 ADH7 markers and 38 unlinked ancestry‐informative markers in 244 subjects with SD [178 European‐Americans (EAs) and 66 African‐Americans (AAs)] and 293 healthy subjects (253 EAs and 40 AAs). The relationships between ADH7 markers and personality traits were comprehensively examined using multivariate analysis of covariance (MANCOVA), and then decomposed by Roy Bargmann Stepdown analysis of covariance (ANCOVA). Generally, older individuals, AAs, and males had significantly lower personality scores (4.7 × 10−5 ≤ P ≤ 0.032), as reported previously. In SD subjects, Extraversion was most significantly associated with ADH7 haplotypes (3.7 × 10−4 ≤ P ≤ 0.001), diplotypes (0.007 ≤ P ≤ 0.012), and genotypes (P = 0.001), followed by Conscientiousness (0.005 ≤ P ≤ 0.033). The contributory haplotype and diplotypes contained the alleles and genotypes of rs284786 (SNP1) and rs1154470 (SNP4). In healthy subjects, other personality factors (except Extraversion) were associated with ADH7 diplotypes (0.005 ≤ P ≤ 0.016) and genotypes (0.002 ≤ P ≤ 0.052). Some of the gene effects on personality factors were modified by sex. The present study demonstrated that the ADH7 variation may contribute to the genetic component of variation in personality traits, with the risk for SD and personality traits being partially shared. © 2007 Wiley‐Liss, Inc.
The functional polymorphism of the hemoglobin‐binding protein haptoglobin influences susceptibility to idiopathic Parkinson's disease
Authors: Costa‐Mallen Paola , Checkoway Harvey , Zabeti Aram , Edenfield Michael J. , Swanson Phillip D. , Longstreth W.T. , Franklin Gary M. , Smith‐Weller Terri , Sadrzadeh Sayed M.H. 
Published: October 2007

AbstractOxidative stress and iron have been widely implicated in the etiology of Parkinson's disease (PD). Hemoglobin is the richest source of iron in the body. The human Haptoglobin (Hp) protein is a plasma alpha‐2 glycoprotein that removes free Hemoglobin from the circulation and tissues and is important in protection from oxidative stress, in immune system regulation, and angiogenesis. A common genetic polymorphism of Hp exists in the population, where the Hp 1‐1, Hp 2‐1, and Hp 2‐2 forms exhibit profound functional differences. In this study, the Hp genotype corresponding to phenotypes Hp 1‐1, 2‐1 and 2‐2 was determined in 312 idiopathic PD patients and 420 normal control subjects. A significant increase in the number of subjects carrying the Hp 2‐1 genotype was present among PD patients. The distribution of Hp genotypes among PD patients (16.0% Hp 1‐1, 56.4% Hp 2‐1, 27.6% Hp 2‐2) was significantly different from the distribution in controls (15.2% Hp 1‐1, 48.1% Hp 2‐1, 36.7% Hp 2‐2) (χ2 = 6.99, P = 0.030). The odds ratios for PD risk for Hp 2‐1 and Hp 1‐1 versus Hp 2‐2 genotype were 1.51 (1.07–2.12) and 1.36 (0.86–2.15), respectively. Overall, the association of Hp‐1 allele with PD resulted stronger among subjects who were never‐smokers as compared to ever‐smokers. Also, among ever‐smokers, Hp genotypes were significantly associated with PD only among women, but not men, indicating the presence of a gene × gender × smoking interaction. To our knowledge, this is the first study that investigates the association of Hp genotypes with the risk of PD. © 2007 Wiley‐Liss, Inc.
Genetic Association of Neurotrophic Tyrosine Kinase Receptor Type 2 (NTRK2) With Alzheimer's Disease
Authors: Chen Zuomin , Simmons Micah S. , Perry Rodney T. , Wiener Howard W. , Harrell Lindy E. , Go Rodney C.P. 
Published: October 2007

AbstractBrain‐derived neurotrophic factor (BDNF)/tyrosine receptor kinase (TRK) signaling pathway activates a wide range of downstream intracellular cascades, regulating neuronal development and plasticity, long‐term potentiation, and apoptosis. The NTRK family encodes the receptors TRKA, TRKB, and TRKC, to which the neurotrophins, nerve growth factor (NGF), BDNF and neurotrophin‐3 (NT‐3) bind, respectively, with high affinity. Signaling through these receptors appears to be compromised in Alzheimer's disease (AD). This study is the most comprehensive investigation of genetic variants of NTRK2, and the first to show significant association between NTRK2 with AD. Fourteen single nucleotide polymorphisms (SNPs), located in 8 of 18 linkage disequilibrium (LD) blocks, were genotyped in 203 families with at least two AD affected siblings with mean age of onset (MAO) of 70.9 ± 7.4 years and one unaffected sibling from the NIMH‐ADGJ dataset. Family based association testing found no single SNP association, however, significant associations were found for two and three locus haplotypes (P = 0.012, P = 0.009, respectively) containing SNPs rsl624327, rsl443445, and rs378645. These SNPs are located in areas of the gene containing sequences that could be involved in alternative splicing and/or regulation of NTRK2. Our results suggest that NTRK2 may be a genetic susceptibility gene contributing to AD pathology. © 2007 Wiley‐Liss, Inc.
Multigram Solution‐Phase Synthesis of Three Diastereomeric Tripeptidic Second‐Generation Dendrons Based on (2S,4S)‐, (2S,4R)‐, and (2R,4S)‐4‐Aminoprolines
Authors: Zhang Afang , Schlüter A. Dieter 
Published: October 2007

AbstractThree diastereomeric second‐generation (G2) dendrons were prepared by using (2S,4S)‐, (2S,4R)‐, and (2R,4S)‐4‐aminoprolines on the multigram scale with highly optimized and fully reproducible solution‐phase methods. The peripheral 4‐aminoproline branching units of all the dendrons have the 2S,4S configuration throughout, whereas those units at the focal point have the 2S,4S, 2S,4R, and 2R,4S configurations. These latter configurations led to the dendrons being named (2S,4S)‐1, (2S,4R)‐1, and (2R,4S)‐1, respectively. The 4‐aminoproline derivatives used in this study are new, although many closely related compounds exist. Their syntheses were optimized. The dendron assembly involved amide coupling, the efficiency of which was also optimized by employing the following well‐known reagents: EDC/HOBt, DCC/HOSu, TBTA/HOBt, TBTU/HOBt, BOP/HOBt, pentafluorophenol, and PyBOP/HOBt. It was found that the use of PyBOP is by far the best for dendrons (2S,4S)‐1 and (2R,4S)‐1, and pentafluorophenol active ester is best for (2S,4R)‐1. Because of their multigram scale, all couplings were done in solution instead of by solid‐phase procedures. Purifications were, nevertheless, easy. The optical purities of the key intermediates as well as the three G2 dendrons were analyzed by chiral HPLC analysis. These novel, diastereomeric second‐generation dendrons have a rather compact and conformationally highly rigid structure that makes them interesting candidates for applications, for example, in the field of dendronized polymers and in organocatalysis.
Alternate PNA‐DNA chimeras (PNA‐DNA)n: Synthesis, binding properties and biological activity
Authors: Moggio Loredana , Romanelli Alessandra , Gambari Roberto , Bianchi Nicoletta , Borgatti Monica , Fabbri Enrica , Mancini Irene , di Blasio Benedetto , Pedone Carlo , Messere Anna 
Published: October 2007

AbstractPeptide nucleic acids (PNAs) are oligonucleotide mimics in which the sugar‐phosphate backbone has been replaced by a pseudo‐peptide backbone. Among PNA‐based molecules, PNA‐DNA conjugates characterized by tracts of DNA bound to N and/or C terminus of PNA are very soluble in aqueous media, are able to recognize exclusively single strands of DNA and RNA in antiparallel fashion, activate RNAse H, bind to transcription factors and are more stable than DNA to nucleases degradation. Very little information is available on chimeras constituted of alternating monomers of PNA and DNA. In this article, we describe a simple fully automated strategy for the synthesis of 6‐mer and 10‐mer alternate PNA‐DNA chimeras consisting of polythymine oligomers, stability assays in fetal calf serum, UV and CD studies of the single strand alternate chimeras and of alternate chimera/DNA and alternate chimera/RNA duplexes. Evidences supporting the formation of duplex hybrids were found. Furthermore, the ability of forming Hoogsteen base pairing with duplex DNA was investigated. Finally, we tested the ability of the PNA‐DNA alternates in (a) interfering with reverse transcription of eukaryotic mRNA and (b) inhibiting DNA‐protein interactions. © 2007 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 88: 815–822, 2007.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Effect of oleic and linoleic acids on the inflammatory phase of wound healing in rats
Authors: Pereira Leonardo M. , Hatanaka Elaine , Martins Edgair F. , Oliveira Flávia , Liberti Edson A. , Farsky Sandra H. , Curi Rui , Pithon‐Curi Tania C. 
Published: October 2007

AbstractInflammation is a crucial step for the wound healing process. The effect of linoleic and oleic acids on the inflammatory response of the skin during the healing process and on the release of pro‐inflammatory cytokines by rat neutrophils in vitro was investigated. A wound in the dorsal surface of adult rats was performed and fatty acids were then topically administered. Both oleic and linoleic acids increased the wound healing tissue mass. The total protein and DNA contents of the wounds were increased by the treatment with linoleic acid. The treatments with oleic and linoleic acids did not affect vascular permeability. However, the number of neutrophils in the wounded area and air pouches was increased and the thickness of the necrotic cell layer edge around the wound was decreased. A dose‐dependent increase in vascular endothelial growth factor‐alpha (VEGF‐α) and interleukin‐1beta (IL‐1β) by neutrophils incubated in the presence of oleic and linoleic acid was observed. Oleic acid was able to stimulate also the production of cytokine‐induced neutrophil chemoattractant in inflammation 2 alpha/beta (CINC‐2α/β). This pro‐inflammatory effect of oleic and linoleic acids may speed up the wound healing process. Copyright © 2007 John Wiley & Sons, Ltd.
Highly Improved Electroluminescence from a Series of Novel EuIII Complexes with Functional Single‐Coordinate Phosphine Oxide Ligands: Tuning the Intramolecular Energy Transfer, Morphology, and Carrier Injection Ability of the Complexes
Authors: Xu Hui , Yin Kun , Huang Wei 
Published: October 2007

AbstractThe functional single‐coordinate phosphine oxide ligands (4‐diphenylaminophenyl)diphenylphosphine oxide (TAPO), (4‐naphthalen‐1‐yl‐phenylaminophenyl)diphenylphosphine oxide (NaDAPO), and 9‐[4‐(diphenylphosphinoyl)phenyl]‐9H‐carbazole (CPPO), as the direct combinations of hole‐transporting moieties, and electron‐transporting triphenylphosphine oxide (TPPO) were designed and synthesized (amines or carbazole), together with their EuIII complexes [Eu(tapo)2(tta)3] (1), [Eu(nadapo)2(tta)3] (2), and [Eu(cppo)2(tta)3] (3; TTA: 2‐thenoyltrifluoroacetonate). The investigation indicated that by taking advantage of the modification inertia of the phosphine oxide ligands, the direct introduction of the hole‐transport groups as chromophore made TAPO, NaDAPO, and CPPO obtain the most compact structure and mezzo S1 and T1 energy levels, which improved the intramolecular energy transfer in their EuIII complexes. The amorphous phase of 1–3 proved the weak intermolecular interaction, which resulted in extraordinarily low self‐quenching of the complexes. The excellent double‐carrier transport ability of the ligands was studied with Gaussian calculations, and the bipolar structure of TAPO and CPPO was proved. The great improvement of the double‐carrier transport ability of 1–3 was shown by cyclic voltammetry. Their HOMO and LUMO energy levels of around 5.3 and 3.0 eV, respectively, are the best results for EuIII complexes reported so far. A single‐layer organic light‐emitting diode of 2 had the impressive brightness of 59 cd m−2 which, to the best of our knowledge, is the highest reported so far. Both of the four‐layer devices based on pure 1 and 2 had a maximum brightness of more than 1000 cd m−2, turn‐on voltages lower than 5 V, maximum external quantum yields of more than 3 % and excellent spectral stability.
Occupation Waves the Way You Have Never Seen Them: The Orthorhombic Quasicrystal Approximants RE13Zn58+δ (RE: Ho, Er, Tm and Lu).
Authors: Piao Shu Ying , Lidin Sven 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Thermal Properties of a Nd:LuVO4 Crystal.
Authors: Ran Donggang , Xia Hairui , Sun Shangqian , Liu Fengqin , Ling Zongcheng , Ge Wenwei , Zhang Huaijin , Wang Jiyang 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Noble Gases Influence the Conductance of Cetineite‐Type Nanoporous Semiconductors.
Authors: Sendor Dorota , Fokwa Boniface P. T. , Dronskowski Richard , Simon Ulrich 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Theoretical Study on the Substitution Reactions of Silylenoid H2SiLiF with CH4, NH3, H2O, HF, SiH4, PH3, H2S, and HCl
Authors: Xie Ju , Feng Dacheng , Feng Shengyu 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Crystal Structure of the New Layer Silicate RUB‐39 and Its Topotactic Condensation to a Microporous Zeolite with Framework Type RRO.
Authors: Wang Y. X. , Gies H. , Lin J. H. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Trioctylphosphine: A General Phosphorus Source for the Low‐Temperature Conversion of Metals into Metal Phosphides.
Authors: Henkes Amanda E. , Schaak Raymond E. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
M(bipyridine)V4O10 (M: Cu, Ag): Hybrid Analogues of Low‐Dimensional Reduced Vanadates.
Authors: Yan Bangbo , Maggard Paul A. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ni3(Mo2O8)(XO3) (X: Se, Te): The First Nickel Selenite and Tellurite‐Containing Mo4 Clusters.
Authors: Jiang Hai‐Long , Xie Zhi , Mao Jiang‐Gao 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Olefin Isomerization Leading to Asymmetric Quaternary Carbon Construction.
Authors: Wang Kan , Bungard Christopher J. , Nelson Scott G. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Aminophosphine—Oxazoline and Phosphoramidite—Oxazoline Ligands and Their Application in Asymmetric Catalysis.
Authors: Bronger Raymond P. J. , Guiry Patrick J. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Enantioselective Synthesis of cis‐α‐Substituted Cycloalkanols and trans‐Cycloalkyl Amines Thereof.
Authors: Fernandez Rosario , Ros Abel , Magriz Antonio , Dietrich Hansjoerg , Lassaletta Jose M. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Enantioselective Organocatalytic Direct Aldol Reaction in an Aqueous Medium.
Authors: Maya Vishnu , Raj Monika , Singh Vinod K. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Organocatalytic Enantioselective Aza‐Michael Reaction of Nitrogen Heterocycles and α,β‐Unsaturated Aldehydes.
Authors: Uria Uxue , Vicario Jose L. , Badia Dolores , Carrillo Luisa 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ruthenium‐Catalyzed Reduction of Allylic Alcohols: An Efficient Isomerization/Transfer Hydrogenation Tandem Process.
Authors: Cadierno Victorio , Francos Javier , Gimeno Jose , Nebra Noel 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Iridium‐Catalyzed, Asymmetric Amination of Allylic Alcohols Activated by Lewis Acids.
Authors: Yamashita Yasuhiro , Gopalarathnam Apsara , Hartwig John F. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Silylation—Desilylation of Propargyl Amides: Rapid Synthesis of Functionalized Aldehydes and β‐Lactams.
Authors: Aronica Laura Antonella , Valentini Giulia , Caporusso Anna Maria , Salvadori Piero 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Palladium‐Containing Nanostructured Silica Functionalized with Pyridine Sites: A Versatile Heterogeneous Catalyst for Heck, Sonogashira, and Cyanation Reactions.
Authors: Polshettiwar Vivek , Hesemann Peter , Moreau Joel J. E. 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reactivity of Aldehydes with Semi‐Stabilized Arsonium Ylide Anions: Synthesis of Terminal (E)‐1,3‐Dienes.
Authors: Habrant Damien , Stengel Bruno , Meunier Stephane , Mioskowski Charles 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Efficient Route to Benzene and Phenol Derivatives via Ring‐Closing Olefin Metathesis.
Authors: Yoshida Kazuhiro , Horiuchi Shingo , Iwadate Noriyuki , Kawagoe Fumihiro , Imamoto Tsuneo 
Published: October 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.