bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of adherence to the 2020 Surviving Sepsis Campaign guidelines for fluid resuscitation in children with suspected septic shock in paediatric emergency departments: a prospective multicentre study
Authors: San Geroteo Julian , Levy Michael , Bailhache Marion , De Jorna Claire , Privat Elodie , Gasmi Oussama , Fuentes-Lopez Maria , Laoudi Yacine , Mazeghrane Mustapha , Malterre Aline , Bories Pauline , Abdel Aal Khaled , Arjoca Iozefina , Gaschignard Jean , Tanchaleune Davy , Minodier Philippe , Audren Fabien , Mazetier Tifanny , Quagliaro Pauline , Raimond Florence , Sieng Soria , Robert Blandine , Wohrer Delphine , De Suremain Nathalie , Dauger Stéphane 
Published: March 2024

BackgroundPaediatric sepsis is the leading cause of death in children under 5 years. No studies have evaluated the application of the Surviving Sepsis Campaign 2020 (SSC-2020) guidelines in paediatric emergency departments (PEDs).ObjectiveTo assess physician adherence to the SSC-2020 fluid resuscitation guidelines in children with suspected septic shock in PEDs.MethodsThis was a prospective multicentre observational study conducted in 21 French hospitals over 5 sequential weeks, between November 2021 and March 2022. Children with suspected septic shock and who received antimicrobial therapy within 72 hours were included. Primary outcome was SSC-2020 fluid resuscitation guidelines adherence (low 0–24%; moderate 25–74%; high 75–100%) according to: bolus volume of 10–20 mL/kg each, exclusive administration of balanced crystalloids at 1 and 24 hours of management, and initiation of fluid resuscitation within 1 hour of septic shock recognition.Results63 children were included. 10 (16%) children had severe sepsis and 2 (3%) met the definition of septic shock. Compared with the SSC-2020 guidelines, 43 (68%) patients received boluses of 10–20 mL/kg; fluid resuscitation was initiated within 1 hour of septic shock recognition in 42 (76%) cases; balanced crystalloids were the only fluids administrated in 35 (56%) and 34 (55%) children at 1 and 24 hours of management, respectively. Main barriers reported by physicians were difficult intravenous access (43%), lack of team training (29%), workload constraints (28%), and absence or out-of-date protocols (24%).ConclusionsThis study found high adherence for fluid resuscitation initiation but moderate adherence for bolus volume and fluid choice.Trial registration numberNCT05066464.
Association between abnormal default mode network homogeneity and sleep disturbances in major depressive disorder
Authors: Huang Muzhi , Ou Yangpan , Li Huabing , Liu Feng , Li Ping , Zhao Jingping , Lang Bing , Guo Wenbin 
Published: March 2024

BackgroundSleep disturbance is a common comorbidity of major depressive disorder (MDD). However, network homogeneity (NH) changes of the default mode network (DMN) in MDD with sleep disturbances are unclear.AimsThe purpose of this study was to probe the abnormal NH in the DMN in MDD with sleep disturbances and to reveal the differences between MDD with or without sleep disturbances.MethodsTwenty-four patients with MDD and sleep disturbances (Pa_s), 33 patients with MDD without sleep disturbances (Pa_ns) and 32 healthy controls (HCs) were recruited in this study. Resting-state functional imaging data were analysed using NH.ResultsCompared with Pa_ns and HCs, Pa_s showed decreased NH in the left superior medial prefrontal cortex and increased NH in the right precuneus. There was a negative correlation between NH in the left superior medial prefrontal cortex and sleep disturbances (r=−0.42, p=0.001) as well as a positive correlation between NH in the right precuneus and sleep disturbances (r=0.41, p=0.002) in patients with MDD.ConclusionsMDD with sleep disturbances is associated with abnormal NH in the DMN, which could differentiate pa_s from pa_ns. The DMN may play a crucial role in the neurobiological mechanisms of MDD with sleep disturbances.
Electronic tags reveal high migratory diversity within the largest Atlantic halibut (Hippoglossus hippoglossus) stock
Authors: Ransier Krista T. , Gatti Paul , Le Bris Arnault , den Heyer Cornelia E. , Claireaux Guy , Wringe Brendan , Fisher Jonathan A. D. 
Published: March 2024

Growing evidence suggests that complex spatial structure occurs within the Scotian Shelf and southern Grand Banks (SSGB) Atlantic halibut stock, yet large knowledge gaps remain about diversity of migratory and spawning behaviors. Here, 71 pop-up satellite archival tags were deployed on large Atlantic halibut (FL: 87–166 cm) between 2012 and 2020. Migration tracks were successfully reconstructed for 43 fish using a hidden Markov geolocation model, and temperature and depth time series were available for an additional nine fish (total n = 52). Five migratory behavior categories were identified: shelf residency, slope residency, shelf-channel migration, shelf-slope migration, and dispersal. High-resolution data for four of 20 physically recovered tags provided evidence of putative spawning behavior in deep channels on the continental shelf and along the continental slope between January and February. Additionally, four halibut displayed previously undocumented periods of sustained, oscillatory vertical movements along the continental slope between November and February. The high migratory diversity observed in this study provides support for the existence of multiple resident and migratory contingents in the SSGB stock in the apparent absence of significant genetic structure.
Revisiting the gravitomagnetic clock effect
Authors: Iorio Lorenzo 
Published: March 2024

AbstractTo the first post-Newtonian order, if two test particles revolve in opposite directions about a massive, spinning body along two circular and equatorial orbits with the same radius, they take different times to return to the reference direction relative to which their motion is measured: it is the so-called gravitomagnetic clock effect. The satellite moving in the same sense of the rotation of the primary is slower, and experiences a retardation with respect to the case when the latter does not spin, while the one circling in the opposite sense of the rotation of the source is faster, and its orbital period is shorter than it would be in the static case. The resulting time difference due to the stationary gravitomagnetic field of the central spinning body is proportional to the angular momentum per unit mass of the latter through a numerical factor which so far has been found to be $$4\pi $$

4
π

. A numerical integration of the equations of motion of a fictitious test particle moving along a circular path lying in the equatorial plane of a hypothetical rotating object by including the gravitomagnetic acceleration to the first post-Newtonian order shows that, actually, the gravitomagnetic corrections to the orbital periods are larger by a factor of 4 in both the prograde and retrograde cases. Such an outcome, which makes the proportionality coefficient of the gravitomagnetic difference in the orbital periods of the two counter-revolving orbiters equal to $$16\pi $$

16
π

, confirms an analytical calculation recently published in the literature by the present author. It is an important result in view of the astrophysical implications of the gravitomagnetic clock effect around Kerr black holes.
Helical separation effect and helical heat transport for Dirac fermions
Authors: Ambruş Victor E. , Chernodub Maxim N. 
Published: March 2024

AbstractAn ensemble of massless fermions can be characterized by its total helicity charge given by the sum of axial charges of particles minus the sum of axial charges of antiparticles. We show that charged massless fermions develop a dissipationless flow of helicity along the background magnetic field. We dub this transport phenomenon as the Helical Separation Effect (HSE). Contrary to its chiral cousin, the Chiral Separation Effect, the HSE produces the helical current in a neutral plasma in which all chemical potentials vanish. In addition, we uncover the Helical Magnetic Heat Effect which generates a heat flux of Dirac fermions along the magnetic field in the presence of non-vanishing helical charge density. We also discuss possible hydrodynamic modes associated with the HSE in neutral plasma.
A Novel Operation Technique for Forearm Deformities in Patients with Brachial Plexus Birth Injury: Retrospective Analysis of 14 Patients
Authors: ALTAŞ Okyar , BAYRAM Serkan , ÖZKAN Safiye , DURMAZ Hayati , AYDIN Atakan 
Published: March 2024

Background: We aimed to evaluate the effectiveness of our novel operation technique that included radial shaft shortening plus supination producing osteotomy and transfer of the biceps brachii tendon to the brachialis tendon in patients with chronic radial head dislocation secondary to brachial plexus birth injury (BPBI). Methods: Fourteen patients with chronic radial head dislocation resulting from BPBI were included in this study, with a minimum 1-year postoperative follow-up period. All patients underwent the same surgical procedure. The range of motion of affected elbow was measured with a standard goniometer. The Mayo Elbow Performance Score (MEPS) was used to measure for evaluation of functional result of these patients. The affected elbow radiograph also obtained in the last visit for evaluation of compatibility of the radiocapitellar joint. Results: Fourteen patients (10 males and 4 females) were included in the study. The average age at the time of surgery was 7.2 (5–8) years and average follow-up was 73.2 ± 19 (36–131) months. Although the forearm active–passive pronation decreased, active–passive supination significantly improved postoperatively (p < 0.001). Ten patients had excellent MEPS results (90 and above), two patients with good results (75 and 80), one patient with fair (65) and one patient with poor result (55). Radiocapitellar reduction was achieved in 78.5% (11/14) of the patients. Conclusions: The novel surgical techniques that included radial shaft shortening plus supination producing osteotomy and transfer of the biceps brachii tendon to the brachialis tendon improved the functional outcomes of patients with chronic radial head dislocation secondary to BPBI. Level of Evidence: Level IV (Therapeutic)
High-resolution Diffusion-weighted Imaging to Detect Changes in Tumor Size and ADC, and Predict Adverse Biopsy Histology during Prostate Cancer Active Surveillance
Authors: Saouaf Rola , Xie Yibin , Kim Sungjin , Raphael Yaniv , Nguyen Christopher , Luthringer Daniel , Daskivich Timothy J. , Lo Eric , Tighiouart Mourad , Li Debiao , Kim Hyung L. 
Published: March 2024

Abstract

Purpose:
Majority of men with low-risk prostate cancer can be managed with active surveillance (AS). This study evaluates a high-resolution diffusion-weighted imaging (HR-DWI) technique to predict adverse biopsy histology (AH), defined as Gleason score ≥7 on any biopsy or ≥3 increase in number of positive biopsy cores on systematic biopsies. We test the hypothesis that high-grade disease and progressing disease undergo subtle changes during even short intervals that can be detected by HR-DWI.

Experimental Design:
In a prospective clinical trial, serial multiparametric MRIs, incorporating HR-DWI and standard DWI (S-DWI) were performed approximately 12 months apart prior to prostate biopsy (n = 59). HR-DWI, which uses reduced field-of-view and motion compensation techniques, was compared with S-DWI.

Results:
HR-DWI had a 3-fold improvement in spacial resolution compared with S-DWI as confirmed using imaging phantoms. For detecting AH, multiparametric MRI using HR-DWI had a sensitivity of 75% and specificity of 83.9%, and MRI using S-DWI had a sensitivity of 71.4% and specificity of 54.8%. The AUC for HR-DWI was significantly higher (0.794 vs. 0.631, P = 0.014). Secondary analyses of univariable predictors of AH showed tumor size increase [OR 16.8; 95% confidence interval (CI): 4.06–69.48; P &lt; 0.001] and apparent diffusion coefficient (ADC) decrease (OR 5.06; 95% CI: 1.39–18.38; P = 0.014) on HR-DWI were significant predictors of AH.

Conclusion:
HR-DWI outperforms S-DWI in predicting AH. Patient with AH have tumors that change in size and ADC that could be detected using HR-DWI. Future studies with longer follow-up should assess HR-DWI for predicting disease progression during AS.

Significance:
We report on a prospective clinical trial using a MRI that has three times the resolution of standard MRI. During AS for prostate cancer, two high-resolution MRIs performed approximately a year apart can detect tumor changes that predict the presence of aggressive cancers that should be considered for curative therapy such as prostatectomy or radiation.
Associations of Circulating Vascular Cell Adhesion Molecule‐1 and Intercellular Adhesion Molecule‐1 With Long‐Term Cardiac Function
Authors: Mathew Daniel T. , Peigh Graham , Lima Joao A.C. , Bielinski Suzette J. , Larson Nicholas B. , Allison Matthew A. , Shah Sanjiv J. , Patel Ravi B. 
Published: March 2024

Background
Although VCAM‐1 (vascular cell adhesion molecule‐1) and ICAM‐1 (intercellular adhesion molecule‐1) have been associated with incident heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF), the associations of VCAM‐1 and ICAM‐1 with sensitive measures of cardiac structure/function are unclear. The objective of this study is to evaluate associations between VCAM‐1, ICAM‐1, and measures of cardiac structure and function as potential pathways through which cellular adhesion molecules promote HFpEF and AF risk.

Methods and Results
In MESA (Multi‐Ethnic Study of Atherosclerosis), we evaluated the associations of circulating VCAM‐1 and ICAM‐1 at examination 2 (2002–2004) with measures of cardiac structure/function on cardiac magnetic resonance imaging at examination 5 (2010–2011) after multivariable adjustment. Mediation analysis of left atrial (LA) strain on the association between VCAM‐1 or ICAM‐1 and AF or HFpEF was also performed. Overall, 2304 individuals (63±10 years; 47% men) with VCAM‐1 or ICAM‐1, cardiac magnetic resonance imaging, and covariate data were included in analysis. Higher VCAM‐1 and ICAM‐1 were associated with lower LA peak longitudinal strain and worse global circumferential left ventricular strain but were not associated with left ventricular myocardial scar or interstitial fibrosis. Lower LA peak longitudinal strain mediated 8% (95% CI, 2–30) of the relationship between VCAM‐1 and HFpEF and 9% (95% CI, 2–21) of the relationship between VCAM‐1 and AF.

Conclusions
Higher VCAM‐1 and ICAM‐1 were associated with lower LA function and left ventricular systolic function but were not associated with myocardial scar or interstitial fibrosis. VCAM‐1 and ICAM‐1 may promote HFpEF and AF risk through impaired LA reservoir function.
Urban Transit Infrastructure and Inequality
Authors: Lee Kwok Hao , Tan Brandon Joel 
Published: March 2024

Abstract
We propose a quantitative spatial model featuring heterogeneous worker groups and their travel to consume non-tradable goods and services. We consider the opening of the Downtown Line (DTL) in Singapore, which connected regions where high-income households have residential amenities to where non-traded sectors are productive. Leveraging transit farecard data, we show that high-income workers saw large welfare gains but low-income workers gained little. Everyone enjoyed improved access to consumption opportunities, but low-income jobs in non-tradables moved to less attractive workplaces. Abstracting from consumption travel understates the disparate impact across worker groups three-fold.
A novel approach to retrograde autologous priming for infant, pediatric and adult populations undergoing congenital heart surgery
Authors: Deptula Joseph , Olshove Vincent , Oldeen Molly , Kozik Deborah , Alsoufi Bahaaldin 
Published: March 2024

Introduction Retrograde Autologous Priming (RAP) of cardiopulmonary bypass (CPB) circuits is an effective way to reduce prime volume, commonly through the transfer of prime into separate reservoirs or circuit manipulation. We describe a simple and safe technique for RAP without the need for any circuit modifications or manipulations. Methods For this technique, a separate roller pump for ultrafiltration (UF) is used. After adequate heparinization and arterial cannulation, the UF pump is initiated slowly, removing prime through the effluent of the UF, replacing with the patient’s blood from the aortic cannula. Once the arterial line and UF circuit are autologous primed, the arterial head displaces reservoir crystalloid toward the UF circuit at a flow rate equal to the UF pump, displacing the crystalloid prime with blood from the UF circuit, autologous priming the boot and oxygenator with blood, crystalloid again being removed by the effluent. After venous cannulation, the venous line prime is replaced with autologous blood, the crystalloid removed by the effluent of the UF circuit via the arterial head. During RAP, if the patient becomes hypovolemic, either autologous volume is transfused back to the patient, or CPB is initiated, without the need for circuitry modifications. Results The patient population in this sample consisted of 63 patients ranging between 6.1 kg and 115.6 kg. The smaller the patient, the less blood volume available for RAP and therefore the less prime volume able to be removed. Overall percent removal increases as our patients size increases compared to total circuit volume. Conclusion This RAP technique is a safe and effective way to achieve a standardized asanguinous prime for many regardless of patient or circuit size in the absence of contraindications such as low starting hematocrit, emergency surgery or physiologic instability. Most importantly, this potentially reduces the amount of hemodilution patients see from CPB initiation and therefore the lowest nadir hematocrit and consequently the amount of required homologous blood products needed during surgery.
Proportion of Antipsychotics with CYP2D6 Pharmacogenetic (PGx) Associations Prescribed in an Early Intervention in Psychosis (EIP) Cohort: A Cross-Sectional Study
Authors: Jameson Adam , Faisal Muhammad , Fylan Beth , Bristow Greg C , Sohal Jaspreet , Dalton Caroline , Sagoo Gurdeep S , Cardno Alastair G , McLean Samantha L 
Published: March 2024

Background: Prescribing drugs for psychosis (antipsychotics) is challenging due to high rates of poor treatment outcomes, which are in part explained by an individual’s genetics. Pharmacogenomic (PGx) testing can help clinicians tailor the choice or dose of psychosis drugs to an individual’s genetics, particularly psychosis drugs with known variable response due to CYP2D6 gene variants (‘CYP2D6-PGx antipsychotics’). Aims: This study aims to investigate differences between demographic groups prescribed ‘CYP2D6-PGx antipsychotics’ and estimate the proportion of patients eligible for PGx testing based on current pharmacogenomics guidance. Methods: A cross-sectional study took place extracting data from 243 patients’ medical records to explore psychosis drug prescribing, including drug transitions. Demographic data such as age, sex, ethnicity, and clinical sub-team were collected and summarised. Descriptive statistics explored the proportion of ‘CYP2D6-PGx antipsychotic’ prescribing and the nature of transitions. We used logistic regression analysis to investigate associations between demographic variables and prescription of ‘CYP2D6-PGx antipsychotic’ versus ‘non-CYP2D6-PGx antipsychotic’. Results: Two-thirds (164) of patients had been prescribed a ‘CYP2D6-PGx antipsychotic’ (aripiprazole, risperidone, haloperidol or zuclopenthixol). Over a fifth (23%) of patients would have met the suggested criteria for PGx testing, following two psychosis drug trials. There were no statistically significant differences between age, sex, or ethnicity in the likelihood of being prescribed a ‘CYP2D6-PGx antipsychotic’. Conclusions: This study demonstrated high rates of prescribing ‘CYP2D6-PGx-antipsychotics’ in an EIP cohort, providing a rationale for further exploration of how PGx testing can be implemented in EIP services to personalise the prescribing of drugs for psychosis.
Novel percutaneous technique for creation of porcine model of tricuspid regurgitation via two routes
Authors: Oh Ji Soo , Kim Ga Yun , Kim Seok Hyun , Lee Sang Hyun , Park Yong Hyun , Kim June Hong , Chon Min Ku 
Published: March 2024

Objective To develop an experimental porcine model of tricuspid regurgitation using two induction routes: the inferior vena cava and superior vena cava. Methods Tricuspid regurgitation was generated using the loop wire cutting method. The tricuspid regurgitation jet direction was controlled by accessing the valve through the inferior (n = 7) or superior (n = 6) vena cava. The occurrence, direction, and progression of tricuspid regurgitation were assessed postoperatively, and echocardiography was performed at 4 to 6 weeks. Right heart dilatation was assessed using computed tomography after 6 weeks. Results Moderate to severe or torrential tricuspid regurgitation occurred immediately after the procedure in 12 of 13 animals. The jet was directed toward the septum in five of seven animals in the inferior vena cava group and toward the posterolateral side in four of six animals in the superior vena cava group. The dimensions of the right heart (right atrium, ventricle, and tricuspid valve annulus) were significantly enlarged at the 4- to 6-week follow-up echocardiographic examination and confirmed to be enlarged by computed tomography, independent of the route used. Conclusion The loop wire cutting method successfully induced a disease model of tricuspid regurgitation while controlling the regurgitation jet direction via two procedural routes.
Degree of awareness and practices on urinary tract infections: A study of Sri Lankan school teachers selected from a chronic kidney disease high-prevalent setting
Authors: Safwan Mohomed , Dias Bhavantha , Dilhari Ayomi 
Published: March 2024

Objective: As key stakeholders in educational settings, teachers’ awareness on Urinary Tract Infections (UTI) will ultimately enhance its management in schools and community. This study aimed to assess the level of knowledge, attitudes, and practices (KAP) on UTIs among teachers in Sri Lanka. Materials and methods: Conveniently selected 373 school teachers were assessed using a pre-tested questionnaire. Each of the individual was scored and categorized as either satisfactory or poor. Descriptive statistics and chi-square tests were performed to describe the outcomes. Results: Around 80% of respondents demonstrated awareness regarding the microbial origin of UTIs, while 42% possessed knowledge of women’s increased susceptibility to UTIs. Over 90% of participants had favorable attitudes toward drinking adequate amounts of water, personal hygiene, and consulting doctors for UTI symptoms. Each inquiry demonstrated significant disparities between individuals with satisfactory and poor attitudes ( p = 0.000), with over 95% adhered to effective hygiene practices as a preventive measure against UTIs. The demographics of the participants did not show any significance over the KAP results of the study ( p < 0.05). Conclusions: The study revealed satisfactory levels of awareness and favorable attitudes among respondents on UTIs. However, there is a further need for increased awareness, specifically regarding the risk factors associated with UTIs.