bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormalities of respiratory gases in synovial fluid of patients with juvenile rheumatoid arthritis
Authors: Goetzl Edward J. , Rynes Richard I. , Stillman J. Sydney 
Published: February 2007

AbstractSynovial fluids from 26 knees of patients with juvenile rheumatoid arthritis were analyzed for partial pressure of oxygen (pO2) and carbon dioxide (pCO2), pH, and for lactate. As in adult rheumatoid arthritis, a low Po2 level was associated with a high concentration of lactate (r = −0.81), and inverse relationships were demonstrated between levels of lactate and pH (r = −0.87), and pCO2 and pH (r = −0.86). These physiologic abnormalities were unrelated to the clinical severity of local joint disease or to the spread of joint involvement.
HL‐A 27 in reactive arthritis. A study of yersinia arthritis and Reiter's disease
Authors: Aho Kimmo , Ahvonen Paavo , Lassus Allan , Sievers Kai , Tiilikainen Anja 
Published: February 2007

AbstractThe histocompatibility antigen HL‐A 27 was identified in 43 of 49 patients with yersinia arthritis and in 36 of 40 patients with Reiter's disease, compared with 3 of 20 patients with yersinia infection without arthritis and 14% of the normal Finnish population. HL‐A 2 occurred in patients with reactive arthritis in the same high frequency as did HL‐A 27, but this antigen is present in 55% of Finns. HL‐A 27 negative patients usually had a mild or somewhat atypical disease.
Multicentric reticulohistiocytosis. Fine structural analysis of the synovium and synovial fluid cells
Authors: Krey Phoebe R. , Comerford Francis R. , Cohen Alan S. 
Published: February 2007

AbstractA patient with progressive multicentric reticulohistiocytosis (MR) had foamy giant cells in the synovial fluid as well as in the synovial membrane and dermis. These cells did not stain for neutral fat, but stained faintly with Sudan Black B and periodic acid‐Schiff. Electron microscopy of these unusual macrophages showed they were filled with vacuoles and inclusions that contained a flocculent material. These inclusions bore a close relationship to the Golgi apparatus and, in some cells, appeared to be developing from smooth endoplasmic reticulum. A 3‐month trial on azathioprine did not improve the patient's arthritis nor reduce the size and number of skin nodules. This is the first patient described with this disorder in whom synovial fluid analysis revealed foamy appearing giant cells and in whom intracellular inclusions were related to the endoplasmic reticuium.
Comprehensive management of patients with rheumatoid arthritis some results of the regional arthritis control program in michigan
Authors: Duff Ivan F. , Carpenter James O. , Neukom Jan E. 
Published: February 2007

AbstractThe present investigation reports on the effects of a program of comprehensive care for patients with rheumatoid arthritis. Five dependent variables representing indices of disease activity were employed in assessing the merit of comprehensive, continuing management when compared with conventional management, often episodic, provided in arthritis clinics. Over the short duration of the project, this controlled study suggests greater benefits for patients in the comprehensive program. Greater insight into the relative benefits of different management modalities may be provided for future projects of this type in which a longer period of observation is possible.
Immunoglobulin E (IgE) levels in serum and synovial fluid in rheumatoid arthritis
Authors: Hunder Gene G. , Gleich Gerald J. 
Published: February 2007

AbstractSerum and synovial fluid levels of immunoglobulin E (IgE) were significantly increased in patients with rheumatoid arthritis (RA) but were normal in degenerative arthritis (DJD) and in samples taken at autopsy in cases without joint disease. No significant correlation was found between serum IgE concentration and severity of RA nor was evidence found of the local production of IgE in synovial fluid in RA. The increased IgE in RA may be the result of a general immune response seen in this disease.
The macrophage‐lymphocyte rosette. Its increased incidence among cells from rheumatoid synovial fluid
Authors: Hepburn Bonnie , McDuffie F. C. , Ritts R. E. 
Published: February 2007

AbstractMacrophage‐lymphocyte rosettes are a prominent feature of rheumatoid synovial fluid cell cultures. They suggest the presence of antigen in or on synovial fluid leukocytes. The majority of lymphocytes found in macrophage‐lymphocyte rosettes have been identified as T cells.
A computer assisted instructional course in diagnosis and treatment of the rheumatic diseases
Authors: Diamond Herbert S. , Weiner Max , Plotz Charles M. 
Published: February 2007

AbstractA computer‐assisted simulation of the “chart method” of teaching has been developed and used to provide instruction in clinical decisionmaking in the diagnosis and treatment of rheumatic diseases. The course requires a student to reach and defend a diagnosis and provide appropriate treatment for each of 10 simulated cases. Evaluation of performance and immediate feedback and correction of errors of commission and omission are an integral part of the course. The course provides a model for the development of additional programs in other subject areas.
Pseudogout in ochronosis
Authors: Rynes Richard I. , Leland Sosman J. , Holdsworth Donald E. 
Published: February 2007

AbstractCalcium pyrophosphate dihydrate crystals were identified in synovial fluid white blood cells during an episode of acute arthritis in a patient with ochronosis and chondrocalcinosis. Review of the histories and radiographs of 5 other patients with ochronosis demonstrated two additional instances of chondrocalcinosis. Both of these patients had episodes of arthritis consistent with pseudogout. This suggests that pseudogout, which has been found in increased incidence in some metabolic diseases, may also be more common in ochronosis.
The hyperviscosity syndrome in rheumatoid arthritis due to intermediate complexes formed by self‐association of IgG‐rheumatoid factors
Authors: Pope Richard M. , Mannik Mart , Gilliland Bruce C. , Teller David C. 
Published: February 2007

AbstractThree patients with rheumatoid arthritis and abundant circulating intermediate complexes were studied. Two of these patients presented with the hyperviscosity syndrome. All 3 patients had markedly elevated plasma and blood viscosity, and the intermediate complexes were thought to be responsible for the increased viscosity. Studies on the isolated intermediate complexes revealed that they were formed by self‐association of IgG‐rheumatoid factors.
HL‐A W27 in psoriatic arthropathy
Authors: Metzger Allan L. , Morris Robert I. , Bluestone Rodney , Terasaki Paul I. 
Published: February 2007

AbstractForty subjects with psoriatic arthritis (PA) underwent HL‐A tissue typing. HL‐A W27 was significantly increased in psoriatic spondylitis (35%), whereas statistical significance was not reached in patients with peripheral arthritis alone, although W27 was present in a frequency greater than in controls. Psoriatic spondylitis (often asymptomatic) occurred in 57% (23 of 40) of our PA patients. Of interest, psoriatic spondylitis was more often W27 negative than W27 positive; nevertheless, W27‐positive and W27‐negative spondylitis was clinically and radiographically indistinguishable except that W27‐positive disease occurred exclusively in males and the duration of the psoriasis was shorter when compared to W27‐negative spondylitis.
Effects of acute cartilaginous injury on serum and cartilage lysozyme levels
Authors: Greenwald Robert A. , Cantor Jerome O. , Schwartz Charles E. , Josephson Alan S. 
Published: February 2007

AbstractAcute cartilage degradation was produced in rabbits by the intravenous injection of crude papain. This resulted in a significant rise in serum lysozyme in 97% of the animals, as well as a fall in the residual lysozyme content of auricular and costal cartilage. The rise in serum lysozyme paralleled the rise in serum chondroitin sulfate. The source of the rise in lysozyme appeared to be the release of extracellular, nonlysosomal lysozyme from the cartilage matrix. Serum lysozyme elevation in arthritic disorders may reflect cartilage degradation.
Depression of cellular‐mediated immunity in systemic lupus erythematosus
Authors: Julian Rosenthal C. , Franklin Edward C. 
Published: February 2007

AbstractCellular‐mediated immunity was examined in 6 consecutive patients with active SLE, 6 patients with low active SLE, 6 patients with DLE, 8 patients with other collagen diseases, and 9 healthy controls. The following parameters were measured: delayed hypersensitivity, in vitro lymphocyte blast transformation, and MIF production after stimulation with five common antigens, DNA, and two nonspecific mitogens (PHA, PWM). The 6 active SLE patients were anergic and had a markedly depressed response in vitro to the specific antigens and PWM (P < 0.001). When CMI was retested in 5 patients as early as 5 days after the start of prednisone (60 mg/day), the results were significantly improved in 4 who also improved clinically, and they remained unchanged in a fifth patient who failed to improve. There was a less marked impairment of CMI among the low active SLE group, whereas the DLE and OCD patients did not differ significantly from the control subjects. DNA did not cause significant stimulation of blast transformation in any of the study groups.
Histochemical and electron microscopic comparison of tissue produced by rabbit articular chondrocytes in VIVO and in VITRO
Authors: Green William T. , Ferguson Roger J. 
Published: February 2007

AbstractRabbit articular chondrocytes produce a chondroid matrix in subculture. This tissue was compared to articular cartilage by histochemical and electron microscopic techniques. Although both tissues were similar, the cytology of chondrocytes and the matrix structure of chondroid tissue appeared less mature.
Surface characteristics of synovial fluid and peripheral blood lymphocytes in inflammatory arthritis
Authors: Brenner Alan I. , Scheinberg Morton A. , Cathcart Edgar S. 
Published: February 2007

AbstractIn order to characterize the T‐ and B‐cell populations of inflammatory arthritides, synovial fluid and peripheral blood lymphocytes from patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), juvenile rheumatoid arthritis (JRA), and rheumatoid variant diseases (RV) were studied. Normal peripheral blood lymphocytes were examined as controls. T cells were identified by spontaneous sheep red blood cell (E) rosette formation. B cells were determined by complement receptor lymphocyte (EAC) rosette formation and by the presence of surface immunoglobulins (SIg) utilizing fluoresceinated polyvalent antiglobulin. Synovial fluids were analyzed in terms of duration, mucin quality, white cell count, and differential. Synovial fluid and peripheral blood lymphocytes from patients with RA and RV were distributed in T‐ and B‐cell percentages similar to those found in normal peripheral blood. In contrast, significant T‐cell depression was observed in the percentage of synovial fluid and peripheral blood lymphocytes of SLE and JRA patients. This depression was apparent in comparison with normal peripheral blood and with the synovial fluid and peripheral blood from RA patients. B‐cell percentages were similar in all patient groups and in comparison to normal peripheral blood lymphocytes. No differences were noted in B‐cell percentages when the EAC and SIg techniques of identification were compared. The percentage of cells bearing neither T‐ nor B‐cell markers (null cells) was enumerated for each patient group and found to be significantly elevated in the synovial fluid and peripheral blood of SLE and JRA patients. Though the mean synovial fluid and peripheral blood null cell percentages in RA patients were similar to those in controls, a definite bimodal distribution was found in the synovial fluids. These data suggest that evaluation of T‐, B‐, and null‐cell populations may be clinically useful in differentiating patients with SLE and JRA from those with rheumatoid arthritis and variant diseases.
Immunologic characterization of the mononuclear cell infiltrates in rheumatoid synovia, in rheumatoid nodules, and in lip biopsies from patients with sjö;ugren's syndrome
Authors: Tannenbaum Hyman , Pinkus Geraldine S. , Anderson Larry G. , Schur Peter H. 
Published: February 2007

AbstractTwo subcutaneous rheumatoid nodules and 8 rheumatoid synovia from patients with rheumatoid arthritis (RA); and 2 parotid glands, 1 “pseudolymphoma,” and 6 lip biopsies from patients with Sjögren' syndrome (SS) were studied to identify mononuclear cells. The palisading mononuclear cells in subcutaneous nodules had a surface membrane receptor for complement. B lymphocytes surrounded by larger numbers of non‐B lymphocytes were found in RA synovium and between salivary ducts of SS lip biopsies. A “pseudolymphoma” obtained from a patient with SS consisted primarily of B lymphocytes. The predominant mononuclear cells in rheumatoid synovia and salivary glands in patients with RA and SS do not have surface membrane receptors for complement and are thus probably T lymphocytes or null cells.
Retardation of colony growth of in vitro bone marrow culture using sera from patients with felty' syndrome, disseminated lupus erythematosus (sle), rheumatoid arthritis, and other disease states
Authors: Duckham Dewey J. , Rhyne Robert L. , Smith Fredrica E. , Williams Ralph C. 
Published: February 2007

AbstractWhole sera and serum fractions from 24 patients with Felty' syndrome, 42 patients with systemic lupus erythematosus (SLE), and 48 paients with rheumatoid arthritis (RA), as well as 30 patients with miscellaneous acute and chronic disease states, were studied for their effect on numbers of mouse bone marrow colonies grown on soft agar in the presence of human colony stimulating factor. Significant early retardation of mouse bone marrow colony counts was recorded in 87.5% of Felty' sera, 43% of SLE sera, and 12.5% of sera from patients with uncomplicated RA. Forty percent of 30 other control patients with acute or chronic inflammatory diseases also showed this activity. No diminution was noted with any of 40 normal control sera. Degree of marrow colony retardation could be directly correlated to amounts of test serum added. No single serum fraction isolated by ion exchange chromatography, gel filtration, or electrophoresis was identified as solely responsible for marrow growth retardation; however lipoprotein fractions including chylomicrons, LDL, and HDL showed inhibiting activity in various sera.
Aspirin‐induced hepatotoxicity in juvenile rheumatoid arthritis a prospective study
Authors: Athreya Balu H. , Moser Glenda , Cecil Henry S. , Myers Allen R. 
Published: February 2007

AbstractRecent reports of and our own experience with biochemical alterations of liver function secondary to salicylate therapy stimulated this prospective study. Thirty‐four children with juvenile rheumatoid arthritis, 6 children with acute cartilagenous necrosis of the hip following slipped capital femoral epiphysis, and 2 children with ulcerative colitis and hip disease who were on salicylates were followed over a period of 1–27 months with serial determinations of serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), lactic dehydrogenase (LDH), alkaline phosphatase (AP), bilirubin, and serum salicylate. Prothrombin time was measured in 14 children. Twenty‐two of 34 children with rheumatoid arthritis and none of the 8 controls demonstrated abnormalities of various liver functions at serum salicylate levels between 7.0 and 43 mg%. Three children demonstrated severe abnormalities characterized by marked elevation of SGOT, SGPT, LDH, and AP, prolongation of prothrombin time, and epistaxis. This type of reaction occurred within 5–14 days of initiation of aspirin therapy and occurred at serum salicylate levels between 18 and 43 mg%. Moderate changes in various liver function tests were observed in 19 other children. None of those children who were tested showed prolongation of prothrombin time. The serum salicylate level in this group varied between 7.0 and 38.2 mg%. The abnormal liver function tests returned to normal in 6 children upon withdrawal of aspirin and in 12 others even when salicylates were continued. Therefore, despite the occurrence of biochemical abnormalities following chronic salicylate therapy, it does not appear to be necessary to discontinue their use except in those children who develop bleeding.
Osteoarthritis of the trapezioscaphoid joint
Authors: Patterson A. Caroline 
Published: February 2007

AbstractIsolated osteoarthritis (OA) of the trapezioscaphoid (TS) joint is little recognized. Nine cases that were examined clinically and radiologically are described. Of these 4 had isolated TS OA, 3 also had generalized OA, and 2 also had rheumatoid arthritis. Symptoms and signs, including pain in the wrist and thumb base, radial and volar swelling, and tenderness over the scaphoid, allowed distinction from other causes of pain at the thumb base. A wrist‐working splint was beneficial in relieving pain.
Bone resorption of the mandible in progressive systemic sclerosis
Authors: Seifert Martin H. , Steigerwald James C. , Cliff May M. 
Published: February 2007

AbstractFive of 16 patients with progressive systemic sclerosis were found to have bone resorption at the angle of the mandible. This finding appears to be closely related to the tightness of the skin of the face, atrophy of the masseter and pterygoid muscles, small size of the oral orifice, and a significantly high frequency in blacks. The mandible must therefore be added to the list of those bones that can be resorbed in progressive systemic sclerosis.
Electron microscopic demonstration of immunoglobulin deposition in rheumatoid cartilage
Authors: Ishikawa Hitoshi , Smiley J. Donald , Ziff Morris 
Published: February 2007

AbstractHorseradish peroxidase (HRPO) conjugated with goat antihuman IgG, goat antihuman IgM, and aggregated human IgG has been used as a enzymatic marker to stain IgG, IgM, and rheumatoid factor in rheumatoid cartilage. When HRPO‐anti IgG and HRPO‐anti IgM were used, immunoglobulin deposits were not observed in nonrheumatoid cartilage. However 7 of 8 rheumatoid cartilage specimens stained with HRPO‐anti IgG showed electron‐dense deposits. Three rheumatoid specimens stained with HRPO‐anti IgM showed similar findings. Both of 2 rheumatoid specimens also stained positively with HRPO conjugated with aggregated IgG, a finding indicating that rheumatoid factor was present. The deposits were seen between the collagen fibers of the superficial layer of the cartilage to a maximal depth of 22 m̈ from the surface (average: 7 m̈). The amorphous fibrinous material on the surface of the cartilage was also stained. The demonstration of IgG, IgM, and rheumatoid factor in the superficial zone of rheumatoid cartilage suggests that immune complexes are deposited in the cartilage in this disease.
Cutaneous vessel immune deposits in rheumatoid arthritis
Authors: Conn Doyt L. , Schroeter Arnold L. , McDuffie Frederic C. 
Published: February 2007

AbstractA study to determine the presence of immune deposits in the cutaneous vessels of normal‐appearing skin was made in 39 patients with rheumatoid arthritis. Immune deposits in skin vessels were found in 20 of the 32 patients with seropositive rheumatoid arthritis. The frequency of such immune deposits was only slightly higher in patients with clinical vasculitis than in those without such vasculitis. There was an association among the presence of immune deposits in skin vessels, presence of antinuclear antibodies, and elevated serum levels of IgM and IgA. The major immunoreactants detected were IgM and C3. The presence of immune deposits in skin vessels does not differentiate seropositive rheumatoid patients who have clinical vasculitis from those who do not have clinical vasculitis.
Treatment of psoriatic arthritis with azaribine
Authors: Levine Seymour , Paulus Harold E. 
Published: February 2007

AbstractThirty‐two patients with psoriatic arthritis unresponsive to conventional therapy were treated with the antipyrimidine azaribine. For the group, improvement was highly significant (P < 0.01) when average painful joint count, ring size, grip strength, pain, and morning gel were compared with baseline measurements. The spectrum of response of individual patients varied from total remission of arthritis in 5 patients to no improvement in 7. Dermatitis improved more than 50% in 26 patients. Reduction in hematocrit, gastrointestinal irritation, and occasional central nervous system toxicity were readily reversed by decreasing or discontinuing dosage. Azaribine appears to be a useful agent for trial in the treatment of refractory psoriatic arthritis.
Lymphocyte responsiveness in systemic lupus erythematosus
Authors: Utsinger Peter D. 
Published: February 2007

AbstractLymphocyte transformation to various mitogens and antigens was studied in selected patients with systemic lupus erythematosus. These patients were selected because they had taken no drug other than low‐dose aspirin for 2 months prior to presentation. An impaired transformation response to the mitogens phytohemagglutinin and pokeweed was found. There was no impairment in the response to PPD and Candida. The impaired mitogen response, which could not be corrected using purified, warm‐washed, and warm‐cultured T lymphocytes, seemed to be a corollary of disease activity.
Serum and synovial fluid inhibitors of antibody‐mediated lymphocytotoxicity in rheumatoid arthritis and systemic lupus erythematosus
Authors: Diaz‐Jouanen Efrain , Bankhurst Arthur D. , Messner Ronald P. , Williams Ralph C. 
Published: February 2007

AbstractMany sera from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) inhibit lymphocyte‐dependent antibody cytotoxicity (LDAC). RA synovial fluids also inhibit LDAC. RA serum inhibition was present in high molecular weight and 5S serum fractions, whereas in SLE it was confined to 7S fractions. A correlation between rheumatoid factor activity and LDAC inhibition was noted, and there was some evidence for inhibition of SLE serum acting on effector cells. Inhibition in RA synovial fluid was found in both high molecular weight and very low molecular weight fractions (<4S).
Intraarticular activation of the complement system in patients with juvenile rheumatoid arthritis
Authors: Rynes Richard I. , Ruddy Shaun , Spragg Jocelyn , Sydney Stillman J. , Frank Austen K. 
Published: February 2007

AbstractAnalyses of CH50, complement components, properdin factors, and kininogen in synovial fluid of patients with juvenile rheumatoid arthritis revealed evidence of activation of the classic complement pathway in all clinical subgroups. Juveniles with the adult pattern of disease had the greatest incidence of complement abnormalities. Evaluation of individual components by both activity determination and protein measurement showed decreased synovial fluid specific functional activity (activity per microgram protein) to be more marked in synovial fluids with profound depressions of complement activity. These findings provide further evidence that nonfunctional, antigenically intact component protein may remain after complement activation. Radial immunodiffusion measurements of properdin factors and kininogen failed to support their involvement in joint inflammation. Serum complement component measurements by activity but not protein concentration correlated with other parameters of inflammation. Four patients had isolated depressions of serum C2 activity. Immunoglobulin levels, particularly IgA, correlated with some complement measurements and with the sedimentation rate.