bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanostructured cobalt(II) phthalocyanine modified screen‐printed electrodes for the determination of thiocyanate in human saliva
Authors: Pavelka Vit , Lazanas Alexandros Ch. , Sarigiannidou Myrto , Hrbac Jan , Prodromidis Mamas I. 
Published: April 2024

AbstractSalivary thiocyanate is a biomarker of individual health that notably allows for the discrimination between smokers and non‐smokers. Recent studies have also demonstrated its potential as a biomarker of cystic fibrosis, thus rendering the development of methods for its determination in saliva of immense importance. In response, we report on the development of graphite screen‐printed electrodes (SPE) modified with cobalt(II) phthalocyanine nanosticks (CoPcNst), as low‐cost and semi‐disposable sensors for the determination of thiocyanate ion (SCN−) in human saliva. CoPCNst were synthesized and characterized using scanning electron microscopy, x‐ray diffraction, as well as infrared and Raman spectroscopies. The results revealed a structural proximity to the recently identified J‐polymorph. Compared with the electrode modified with commercial, beta‐structure cobalt(II) phthalocyanine, the CoPc Nst/SPE provided four times better LOD and LOQ (0.49 and 1.62 μM) for thiocyanate determination by differential pulse voltammetry. The response was linear up to 20 μM SCN− (R2=0.996) and it was not affected by excess of common electro active compounds, such as ascorbic and uric acid. The analytical utility of CoPc Nst/SPE in human saliva is demonstrated.
Edible oleogels for oral delivery of berberine in dairy food: In‐vitro digestion study
Authors: Sarraf Mozhdeh , Beigbabaei Adel , Naji‐Tabasi Sara 
Published: April 2024

AbstractOleogel is a viscoelastic, spreadable and semi‐solid structure, which is used as a fat substitute and a controller the release of bioactive compounds. The aim of this study was to develop low fat dairy dessert enriched with berberine with applying oleogel system as delivery system and fat replacer. The oleogel prepared with an emulsion‐templated methods based on soluble interaction of whey protein concentrate (WPC), WPC‐basil seed gum (BSG), and WPC‐xanthan gum (XG). In the first step, berberine release kinetic in in‐vitro gastrointestinal environment was studied. The results showed that the mouth environment had the highest release rate of berberine. Cooperation of hydrocolloids in oleogel increase stability of structure in stomach condition in compared with WPC oleogel. The suitable model to fit the oleogels contain beberine was the Korsmeyer‐Papas that was the highest R2 (.98). According to release results of berberine from oleogel network, the oleogel 0.6BSG:WPC was chosen and applied in formulation of dairy dessert at different levels (0%, 25%, 50%, 75% and 100% of oleogel) instead of cream. The dessert contained uncoated berberine had the unacceptable bitterness in comparison with samples containing coated berberine with oleogel. The overall acceptance decreased with increment of oleogel due to increasing of bitter taste. Appling berberine (therapeutic compound) and oleogel (fat‐substitute) to achieve marketable consumer products showed positive effects on trend of the study, especially at low level of substitution.
Induction of labor in term pregnancies with isolated polyhydramnios: Is it beneficial or harmful?
Authors: Lerner Yael , Peled Tzuria , Priner Adler Shira , Rotem Reut , Sela Hen Y. , Grisaru‐Granovsky Sorina , Rottenstreich Misgav 
Published: April 2024

AbstractObjectiveTo compare rates of adverse pregnancy outcomes in term pregnancies complicated by polyhydramnios between women who had induction of labor (IOB) versus women who had expectant management.MethodsThis multicenter retrospective study included term pregnancies complicated by isolated polyhydramnios. Patients who underwent IOB were compared with those who had expectant management. The primary outcome was defined as a composite adverse maternal outcome, and secondary outcomes were various maternal and neonatal adverse outcomes. Univariate analyses were followed by multivariate logistic regression.ResultsA total of 865 pregnancies with term isolated polyhydramnios were included: 169 patients underwent IOB (19.5%), while 696 had expectant management and developed spontaneous onset of labor (80.5%). Women who underwent IOB had significantly higher rates of composite adverse maternal outcome (23.1% vs 9.8%, P < 0.01), prolonged hospital stay, perineal tear grade 3/4, intrapartum cesarean, postpartum hemorrhage, blood products transfusion, and neonatal asphyxia compared with expectant management. While the perinatal fetal death rate was similar between the groups (0.6% vs 0.6%, P = 0.98), the timing of the loss was different. Four women in the expectant management group had a stillbirth, while in the induction group one case of intrapartum fetal death occurred due to uterine rupture. Multivariate analyses revealed that IOB was associated with a higher rate of composite adverse maternal outcome (adjusted odds ratio, 2.22 [95% CI, 1.28–3.83]; P < 0.01).ConclusionIOB in women with term isolated polyhydramnios is associated with higher rates of adverse maternal outcomes in comparison to expectant management. Further research is needed to determine the optimal approach for the management of isolated polyhydramnios at term.
Expanding horizons in conceptual density functional theory: Novel ensembles and descriptors to decipher reactivity patterns
Authors: Hoffmann Guillaume , Guégan Frédéric , Labet Vanessa , Joubert Laurent , Chermette Henry , Morell Christophe , Tognetti Vincent 
Published: April 2024

AbstractConceptual density functional theory (CDFT) and the quantum reactivity descriptors stemming from it have proven to be valuable tools for understanding the chemical behavior of molecules. This article is presented as being intrinsically of dual character. In a first part, it briefly reviews, in a deliberately didactical way, the main ensembles in CDFT, while the second half presents two additional ensembles, where the chemical hardness acts as a natural variable, and their respective reactivity descriptors. The evaluation of these reactivity descriptors on common organic chemical reagents are presented and discussed.
Making meaning of one's own life story in words and images: A narrative case report of personal recovery from personality disorder through the interventions “An Empowering Story” and art therapy
Authors: Haeyen Suzanne , Heres Hilda , Pol Silvia 
Published: April 2024

AbstractUnderstanding and processing life experiences are essential in the treatment of personality disorders to promote personal recovery and psychological wellbeing. In this qualitative case report, drafted in co‐creation between the client, clinical psychologist, and art therapist, individual treatment consisted of two psychotherapeutic interventions, “An Empowering Story” and life‐story‐focused art therapy, in 12 parallel sessions for 24 weeks. Hilda, 68 years of age, had been diagnosed with an unspecified personality disorder and various traits of borderline personality disorder. She experienced emotional exhaustion following long‐term mental health problems rooted in a traumatic early childhood. This affected her ability to manage her emotions and social relations, resulting in the sense that her life had no meaning. Hilda was invited to reconstruct her life experiences, divided into the past, turning point, and present/future, in a written and a painted life story. This allowed for the integration of traumatic as well as positive memories, enhanced self‐compassion, and meaning making. She developed self‐reflection and integration of internal conflicts leading to a better emotional balance and self‐understanding. Art therapy emphasizes bottom‐up regulatory processes, while narrative psychology supports top‐down regulatory processes. The combined approach effectively integrated bottom‐up, experiential, sensory experiences with top‐down, cognitive emotion‐regulation processes. The results suggest that psychotherapeutic interventions involving a multi‐pronged, complementary, and thus more holistic approach can support personal recovery in personality disorders.
A latent profile analysis of moral emotions following moral transgressions
Authors: Cenkner David P. , Held Philip , Zalta Alyson K. 
Published: April 2024

AbstractObjectiveMoral transgressions (MTs), events that violate one's moral code, are associated with the moral emotions of guilt and shame. However, there may be different patterns by which people experience guilt and shame that affect distress following MTs.MethodUndergraduates (N = 1371) exposed to an MT completed self‐report assessments. This study used latent profile analysis (LPA) to examine profiles based on guilt cognitions, internalized shame, and distress in relation to a reported MT. Cognitive flexibility, years since the MT, and deliberate and intrusive rumination were examined as variables to determine how these factors predicted profile membership.ResultsResults from the LPA revealed a three‐profile solution: a low moral distress profile (n = 1002), a moderate moral distress profile (n = 262), and a shame prominent profile (n = 107). Results indicated that higher levels of deliberate and intrusive rumination and lower levels of cognitive flexibility significantly increased the likelihood of belonging to the moderate moral distress or shame prominent profiles compared to the low moral distress profile. Higher levels of intrusive rumination and lower levels of cognitive flexibility also significantly increased the likelihood of belonging to the shame prominent profile over the moderate distress profile.ConclusionThree different profiles emerged, with the shame prominent profile being driven primarily by internalized shame. Results suggest that intrusive rumination and cognitive inflexibility are risk factors to experiencing adverse responses to MTs.
Deficient glycan extension and endoplasmic reticulum stresses in ALG3‐CDG
Authors: Daniel Earnest J. P. , Edmondson Andrew C. , Argon Yair , Alsharhan Hind , Lam Christina , Freeze Hudson H. , He Miao 
Published: April 2024

AbstractALG3‐CDG is a rare congenital disorder of glycosylation (CDG) with a clinical phenotype that includes neurological manifestations, transaminitis, and frequent infections. The ALG3 enzyme catalyzes the first step of endoplasmic reticulum (ER) luminal glycan extension by adding mannose from Dol‐P‐Man to Dol‐PP‐Man5GlcNAc2 (Man5) forming Dol‐PP‐Man6. Such glycan extension is the first and fastest cellular response to ER stress, which is deficient in ALG3‐CDG. In this study, we provide evidence that the unfolded protein response (UPR) and ER‐associated degradation activities are increased in ALG3‐CDG patient‐derived cultured skin fibroblasts and there is constitutive activation of UPR mediated by the IRE1‐α pathway. In addition, we show that N‐linked Man3‐4 glycans are increased in cellular glycoproteins and secreted plasma glycoproteins with hepatic or non‐hepatic origin. We found that like other CDGs such as ALG1‐ or PMM2‐CDG, in transferrin, the assembling intermediate Man5 in ALG3‐CDG, are likely further processed into a distinct glycan, NeuAc1Gal1GlcNAc1Man3GlcNAc2, probably by Golgi mannosidases and glycosyltransferases. We predict it to be a mono‐antennary glycan with the same molecular weight as the truncated glycan described in MGAT2‐CDG. In summary, this study elucidates multiple previously unrecognized biochemical consequences of the glycan extension deficiency in ALG3‐CDG which will have important implications in the pathogenesis of CDG.
How meaning in life and vitality are associated with posttrauma outcomes: A systematic review
Authors: Mutuyimana Celestin , Maercker Andreas 
Published: April 2024

AbstractWhen confronted with a traumatic event, people may suffer from adverse posttraumatic outcomes, such as posttraumatic stress disorder (PTSD) or complex PTSD (CPTSD). Positive psychology research has shown that meaning in life and vitality are potentially correlated protective factors against negative developments following trauma exposure that can lead to PTSD or CPTSD. This systematic review aimed to synthesize global empirical research findings, emphasizing the impact of meaning in life and vitality on both PTSD and CPTSD. A search of empirical studies was performed within the Embase, Scopus, and Web of Science core collection databases, as well as PsycInfo, using the PRISMA checklist. A total of 29 studies were included after a systematic exclusion process. The collective findings from 22 studies examining meaning in life and five studies focusing on vitality revealed a consistent negative association with symptoms of PTSD. No study that explored the associations among meaning in life, vitality, and CPTSD was found. In contrast to vitality, meaning in life has been extensively studied in relation to traumatic stress worldwide, and few discrepancies in results were found. This systematic review identified the need to intensify scientific efforts in capitalizing on meaning in life as a possible target for psychological interventions, especially for trauma survivors globally, and to consider vitality as a protective factor that needs more empirical attention in relation to posttraumatic stress. Furthermore, there is a need for studies that encompass diverse target samples and employ longitudinal study design to examine the associations between protective factors and CPTSD.
Dimensional approaches to studying, assessing, and treating traumatic stress: Introduction to the Special Section
Authors: Yalch Matthew M. 
Published: April 2024

AbstractDimensional models of psychopathology are gaining empirical support and are, thus, increasingly common in research and clinical practice. This is true for traumatic stress studies, although the movement toward dimensional conceptualizations of traumatic stress may be somewhat slower, perhaps due at least in part to how trauma is diagnosed. The purpose of this special section is to collect and showcase cutting‐edge basic, applied, and conceptual work on dimensional models of traumatic stress. Its goal is to highlight the utility of such models and to facilitate greater connection between traumatic stress studies and the broader dimensional movement in psychopathology.
Investigation on structure, evaporation, and desiccation cracking of soil with straw biochar
Authors: Yang Binbin , Chen Yang , Yuan Shichong 
Published: April 2024

AbstractTo investigate the cracking behavior in the evaporation process of the soil surface with biochar as an additive, five experimental groups were established in the natural environment with 0, 12, 60, 120, and 170 g·kg−1 biochar. The results of an investigation on organic matter and aggregations indicate that a high content of biochar can significantly improve the content of organic matter and the amount of soil aggregates. After adding 60 and 170 g·kg−1 biochar, the content of organic matter increased by 19.47% and 84.12%, respectively, and the content of soil aggregates with an average diameter greater than 0.25 mm increased by 16.43% and 38.20%, respectively. The investigation also examines the evaporation and cracking characteristics of soils that contain biochar. The rate of evaporation is approximately a “step” type function with time. The rate of evaporation is observed in three stages: the rapid, decelerating, and final evaporation stages. In the rapid evaporation stage, the initial evaporation rate of the sample that contains biochar is increased on average by 46%. The fractal dimension and cracks rate are decreased by 22.95% and 20.99% with 120 g·kg−1 biochar addition. This means that the increase of soil organic matter after adding biochar plays a crucial role in the stability of aggregates. As a soil conditioner, biochar has the ability to enhance soil water retention capacity and is a sustainable strategy to improve soil properties.
Clinical and Molecular Spectrum of Autosomal Recessive CA8‐Related Cerebellar Ataxia
Authors: Kaiyrzhanov Rauan , Ortigoza‐Escobar Juan Darío , Stringer Brett W. , Ganieva Manizha , Gowda Vykuntaraju K. , Srinivasan Varunvenkat M. , Macaya Alfons , Laner Andreas , Onbool Enas , Al‐Shammari Randa , Al‐Owain Mohammed , Deconinck Nicolas , Vilain Catheline , Dontaine Pauline , Self Eleanor , Akram Rabia , Hussain Ghulam , Baig Shahid Mahmood , Iqbal Javed , Salpietro Vincenzo , Neshatdoust Maedeh , Kasiri Mahboubeh , Yesil Gozde , Uygur Turkan , Pysden Karen , Berry Ian R. , Alves Cesar Augusto , Giacomotto Jean , Houlden Henry , Maroofian Reza 
Published: April 2024

AbstractBackgroundBased on a limited number of reported families, biallelic CA8 variants have currently been associated with a recessive neurological disorder named, cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CAMRQ‐3).ObjectivesWe aim to comprehensively investigate CA8‐related disorders (CA8‐RD) by reviewing existing literature and exploring neurological, neuroradiological, and molecular observations in a cohort of newly identified patients.MethodsWe analyzed the phenotype of 27 affected individuals from 14 families with biallelic CA8 variants (including data from 15 newly identified patients from eight families), ages 4 to 35 years. Clinical, genetic, and radiological assessments were performed, and zebrafish models with ca8 knockout were used for functional analysis.ResultsPatients exhibited varying degrees of neurodevelopmental disorders (NDD), along with predominantly progressive cerebellar ataxia and pyramidal signs and variable bradykinesia, dystonia, and sensory impairment. Quadrupedal gait was present in only 10 of 27 patients. Progressive selective cerebellar atrophy, predominantly affecting the superior vermis, was a key diagnostic finding in all patients. Seven novel homozygous CA8 variants were identified. Zebrafish models demonstrated impaired early neurodevelopment and motor behavior on ca8 knockout.ConclusionOur comprehensive analysis of phenotypic features indicates that CA8‐RD exhibits a wide range of clinical manifestations, setting it apart from other subtypes within the category of CAMRQ. CA8‐RD is characterized by cerebellar atrophy and should be recognized as part of the autosomal‐recessive cerebellar ataxias associated with NDD. Notably, the presence of progressive superior vermis atrophy serves as a valuable diagnostic indicator. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Autism spectrum disorder profiles in RASopathies: A systematic review
Authors: Debbaut Edward , Steyaert Jean , El Bakkali Mouna 
Published: April 2024

AbstractBackgroundRASopathies are associated with an increased risk of autism spectrum disorder (ASD). For neurofibromatosis type 1 (NF1) there is ample evidence for this increased risk, while for other RASopathies this association has been studied less. No specific ASD profile has been delineated so far for RASopathies or a specific RASopathy individually.MethodsWe conducted a systematic review to investigate whether a specific RASopathy is associated with a specific ASD profile, or if RASopathies altogether have a distinct ASD profile compared to idiopathic ASD (iASD). We searched PubMed, Web of Science, and Open Grey for data about ASD features in RASopathies and potential modifiers.ResultsWe included 41 articles on ASD features in NF1, Noonan syndrome (NS), Costello syndrome (CS), and cardio‐facio‐cutaneous syndrome (CFC). Individuals with NF1, NS, CS, and CFC on average have higher ASD symptomatology than healthy controls and unaffected siblings, though less than people with iASD. There is insufficient evidence for a distinct ASD phenotype in RASopathies compared to iASD or when RASopathies are compared with each other. We identified several potentially modifying factors of ASD symptoms in RASopathies.ConclusionsOur systematic review found no convincing evidence for a specific ASD profile in RASopathies compared to iASD, or in a specific RASopathy compared to other RASopathies. However, we identified important limitations in the research literature which may also account for this result. These limitations are discussed and recommendations for future research are formulated.
Extracellular vesicle‐based biomarker in head and neck cancer: prospects and challenges
Authors: Wang Linlin , Li Ling , Zhu Guiquan 
Published: April 2024

AbstractHead and neck squamous cell carcinoma (HNSCC) represents the sixth most common malignancy worldwide. However, very few established diagnostic biomarkers for HNSCC have been universally applied in clinical practice. Recently, much attention has been paid to extracellular vesicles (EVs) regarding their roles as cancer biomarkers because EVs carry plentiful cargoes, including lipids, proteins, nucleic acids, and metabolites. In HNSCC, several molecules carried by EVs, which are derived from peripheral blood and saliva, have been implicated to be effective in cancer detection, staging, treatment planning, response monitoring, and prognosis prediction. Although several EV molecules have been identified to be significantly correlated with a set of clinical‐pathological parameters of HNSCC, several key limitations need to be resolved before the clinical application of EVs as carriers of biomarkers in HNSCC. In this review, we discuss current knowledge in the literature regarding EV‐based biomarkers in HNSCC, emphasizing current limitations of their clinical applications.
Establishment of Bull Trout in a previously fishless subalpine lake by translocation
Authors: Kissinger Benjamin C. , Sullivan Michael G. , Paul Andrew J. , Meinke Adrian , Post John 
Published: April 2024

Abstract

Objective
Translocations have increased in recent years to aid in species recovery efforts. This includes translocations outside of species' historical distribution, where threats are less severe. One candidate species for translocation is the Bull Trout Salvelinus confluentus, but few examples of successful translocations (re-establishment or range expansion) have been documented. Here, we describe an example in which 63 Bull Trout were translocated in 1987 to establish a population in fishless Marie Lake, Alberta.

Methods
The translocation was monitored through multiple sampling events over the course of 33 years. Sampling techniques included backpack electrofishing, angling, and water quality and habitat assessments.

Result
A population estimate suggested that Bull Trout increased by at least fourfold over the first 12 years; fish reached large sizes (692 mm fork length) and old ages (13 years), and the population had multiple age- and length-classes, including juveniles. Bull Trout also had become established within at least 13 km of river outside of Marie Lake by 2019.

Conclusion
Although a naturally reproducing population of this at-risk species was established, numerous factors were not considered within this translocation initiative. Most importantly, nonadfluvial Bull Trout from a disparate source population located about 4000 river kilometers away were used for the translocation. Our case study represents a rare example of a successful Bull Trout translocation and highlights considerations that should occur prior to future translocations that are intended to aid in species recovery and preservation.