bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visionary or hallucinatory workplace opportunities
Authors: Birnbaum David 
Published: October 2007

PurposeThe paper aims to discuss discrepancies between recruiting representation versus workplace reality.Design/methodology/approachThe approach is to provide a viewpoint of discrepancies between recruiting representation versus workplace reality.FindingsAll large organizations aspire to be recognized in a positive manner, but many might not truly appreciate the contrary signals broadcast by their responses to job applicants. Facing a well‐recognized global shortage of qualified individuals in most health care professions, hospital systems and public health agencies tend in job advertising to portray themselves as great places to work. However, their reply to applicants who respond can quickly dispel that illusion, driving away the sought after best and brightest who also just might tell their friends …Originality/valueThe paper provides a viewpoint of discrepancies between recruiting representation versus workplace reality.
Intuition and surprise
Authors: Powers Michael R. 
Published: October 2007

PurposeThis editorial seeks to address the importance of intuition and metaphor in the construction of logical systems of thought.Design/methodology/approachTwo unconventional approaches to probability theory are considered, one based upon the non‐intuitive law of the excluded middle, and one based upon the notion of surprise.FindingsIt is argued that formal systems based upon non‐intuitive assumptions/axioms are generally less likely to be accepted by researchers. Nevertheless, it sometimes is possible to identify unconventional systems with greater intuitive appeal than their more orthodox counterparts.Originality/valueThe editorial emphasizes an aspect of formal mathematical systems – intuition – that is often overlooked.
Calibrating risk‐neutral default correlation
Authors: Luciano Elisa 
Published: October 2007

PurposeThe implementation of credit risk models has largely relied either on the use of historical default dependence, as proxied by the correlation of equity returns, or on risk neutral equicorrelation, as extracted from CDOs. Contrary to both approaches, the purpose of this paper is to infer risk neutral dependence from CDS data, taking counterparty risk into consideration and avoiding equicorrelation. The impact of risk neutral correlation on the fees of some higher dimensional credit derivatives is also explored.Design/methodology/approachCopula functions are used in order to capture dependency. An application to market data is provided.FindingsBoth in the FtD and CDO cases, using (the correct) risk neutral measure instead of equity dependency has the same effect as the adoption of a copula with tail dependency instead of a Gaussian one. This should be important for those who resort to copulas in credit derivative pricing.Originality/valueAs far as is known, several attempts have been made in order to compare the behavior of different copulas in derivative pricing; however, no attempt has been made in order to extract risk neutral dependence without using the equicorrelation assumption. Therefore no attempt has been made to understand which copula features could proxy for risk neutrality, whenever risk neutral dependency cannot be inferred (for instance because CDS involving that name are not actively traded)
The impact of national culture on the meaning of information system success at the user level
Authors: Agourram Hafid , Ingham John 
Published: October 2007

PurposeThe purpose of this paper is to understand how people from different national cultures; France, Canada and Germany, define and perceive information systems success.Design/methodology/approachThis is exploratory research that used a grounded theory approach to analyze qualitative data that were collected using an open interview data collection technique. Grounded theory helps to develop new concepts and new theory.FindingsThe findings confirm the divergence thesis. The authors found that people from different national cultures define information systems differently. The authors developed models that groups information systems success as they are defined in France, Canada and Germany.Research limitations/implicationsThere are many limitations in this research. First, the findings concern only one single multinational organization. The authors' aim was analytical and not statistical generalization. Second, although the number of respondents was sufficient to develop a partial theory, the authors could not meet with a larger number of people to get more insights.Practical implicationsThere are many practical implications. Multinational organizations that seek to standardize their information systems need to be aware that the implementation as well as long term success of the standard system will not be homogenous. Moreover, the results of the study reveal that information quality and other systems based concepts are not defined the same way in all cultures. Finally, the study proposes a tool that would help the case organization measure IS success in these three cultures.Originality/valueThis study is unique in a sense that not only does it claim that culture does impact IS success, but it also goes a step further and defines what IS success is in different national cultures.
Information risks management in supply chains: an assessment and mitigation framework
Authors: Nishat Faisal Mohd , Banwet D.K. , Shankar Ravi 
Published: October 2007

PurposeThis paper aims to identify various information risks that could impact a supply chain, and develops a conceptual framework to quantify and mitigate them.Design/methodology/approachGraph theory has been used to quantify information risks while interpretive structural modelling (ISM) is employed to understand the interrelationships among the enablers of information risks mitigation.FindingsThe research presents a classification of the enablers of information risks mitigation according to their driving power and dependence. It also presents a risk index to quantify information risks. The research suggests that management should focus on improving the high driving power enabler variables.Practical implicationsThe proposed risk index and the hierarchy‐based model would help to develop suitable strategies to manage information risks in supply chains.Originality/valueThe major contribution of this paper lies in the development of a framework to quantify information risks and a hierarchy based model for their mitigation in context of supply chains.
Process based information systems evaluation: towards the attributes of “PRISE”
Authors: Özkan Sevgi , Hackney Ray , Bilgen Semih 
Published: October 2007

PurposeThe purpose of this paper is to demonstrate the importance of undertaking a systemic view of information systems evaluation that augments the frequently reported prescriptive (cost/benefit) analysis approaches.Design/methodology/approachThe paper adopts a qualitative case perspective and derives a framework for substantive information systems evaluation factors (PRISE). Three empirical formulations are considered and a comparison made to determine the content and context of the findings.FindingsThe findings support the flexibility and relevance of PRISE as a framework for information systems evaluation. It notes the objectives, relations and components for explicitly identifying the outputs required to make a valid assessment of the systems.Research limitations/implicationsThe study is limited contextually where attention should be made not to generalise the findings beyond the empirical findings within the case analysis. Further studies may usefully include the main features of PRISE but taking into account their unique research environment.Practical implicationsThe study supports a practitioner perspective through a consideration of a holistic approach to information systems evaluation. Managers may implement the notion of including people, resources and benefits in their attempts to determine the added value of these systems to the organisation that extends beyond a simple financial calculation.Originality/valueThe paper is highly original as the framework has been derived through both theoretical constructs and empirical analysis. It provides an innovative approach to information system evaluation that is intellectually sound and practically orientated.
Implementation of advanced manufacturing technology in Pakistani small and medium enterprises
Authors: Marri H.B. , Gunasekaran A. , Sohag R.A. 
Published: October 2007

PurposeThe purpose of this research is to develop a framework/model for the implementation of advanced manufacturing technologies (AMTs) in small and medium enterprises (SMEs).Design/methodology/approachA quantitative approach has been applied. This approach is subjective, as is the data collected and compared in detailed, and the outcome is only as good as the questions developed. The research methodology employed here is based on a literature survey, a model/framework and an empirical analysis using the data collection from the structured questionnaire from SMEs located in the Province of Sindh in Pakistan.FindingsThere is a lack of engineering orientation, in‐house expertise and organizations long‐term vision to accept new technologies. The surveyed companies are giving less importance to arranging training and education facilities either in‐house or out side of the companies to their employees. Also, there is a lack of incentives and rewards scheme inside the surveyed companies.Originality/valueThe framework developed in this paper and findings of the research results will provides a road‐map to the SMEs who are in a process of implementing AMT.
Immunohistochemical comparison of β‐catenin expression by human normal epidermis and epidermal tumors
Authors: FUKUMARU Keiko , YOSHII Noriko , Kanzaki Tamotsu , KANEKURA Takuro 
Published: October 2007

ABSTRACTβ‐Catenin, a cytoplasmic protein that binds directly to the intracellular domain of cadherin, controls various functions such as cell adhesion. In many human carcinomas, E‐cadherin‐mediated cell–cell adhesion is lost or disturbed and related to metastasis. The purpose of this study was to compare the expression of β‐catenin in the normal epidermal keratinocytes and samples from cutaneous benign and malignant epidermal tumors in 140 patients. Our study population consisted of 140 patients with benign or malignant epidermal tumors. Using immunohistochemical methods, we compared the expression of β‐catenin in their normal epidermal keratinocytes, and in samples from 61 benign (seborrheic keratosis, n = 33; verruca vulgaris, n = 14; keratoacanthoma, n = 14), and 79 malignant (Bowen's disease, n = 18; basal cell carcinoma, n = 33; squamous cell carcinoma, n = 28) epidermal tumors. β‐Catenin was found to be expressed in the cell membrane of normal keratinocytes. Compared to other cell components of the normal epidermis, basal cells showed the strongest β‐catenin expression in all 140 patients. While absent in three of 61 benign tumors, compared to normal basal cells, the expression of β‐catenin in the other 58 tumors was not significantly different; it was reduced in 71 of 79 malignant tumors (P < 0.0001). In Bowen's disease, the expression of β‐catenin on the tumor cell membrane was reduced, however, strong expression was seen in the nuclei and cytoplasm. Our results suggest that β‐catenin expression on the membrane of keratinocytes is associated with the differentiation of normal keratinocytes but not with their stage of differentiation, nor with the proliferation ability of epidermal tumor cells.
Case of superficial mucocele of the lower lip
Authors: OKA Masahiro , NISHIOKA Eri , MIYACHI Rieko , TERASHIMA Mina , NISHIGORI Chikako 
Published: October 2007

ABSTRACTSuperficial mucocele is a relatively rare bullous disease that develops in the oral mucosa. Although the number of reported cases is limited, it seems that the superficial mucocele has been recognized as an independent disease belonging to a single entity. We report a 48‐year‐old woman who repeatedly developed superficial mucocele in the oral mucosa. When she was admitted to our hospital she had a tense vesicle on her lower lip. A skin biopsy was taken from the vesicle. A blister containing neutrophils and erythrocytes was present in the mucous epithelium. There was a dermal infiltrate comprising neutrophils, mononuclear lymphocytic cells and eosinophils. Dilated salivary gland excretory ducts were seen in the lamina propria mucosae. Eosinophilic and amorphous materials, which were periodic acid‐Schiff positive after digestion with diastase, and alcian blue positive, were deposited in the blister. Direct immunofluorescence was negative for immunoglobulin (Ig)G, IgM, IgA, C1q, C3 and C4. These histological findings led us to make a diagnosis of superficial mucoceles.
Localized Darier's disease in a Blaschkoid distribution: Two cases of phenotypic mosaicism and a review of mosaic Darier's disease
Authors: SANDERSON Elisabeth A. , KILLORAN Christina E. , ANITA Pedvis‐Leftick , WILKEL Caroline S. 
Published: October 2007

ABSTRACTDarier's disease is a rare autosomal dominant genodermatosis. Characteristic skin and nail changes consist of bilateral crusted red‐brown papules and plaques in a seborrheic distribution, and V‐shaped nicking or longitudinal ridging of the nails. In limited cases, a segmental distribution of this disease may be present in which localized lesions, found along the lines of Blaschko, are otherwise indistinguishable from those of generalized Darier's disease. Genomic mosaicism in localized lesions of Darier's disease is a new concept that was recently demonstrated in individuals of mosaic phenotypes. Both type 1 and type 2 mosaic phenotypes have been reported. We report two cases of type 1 localized Darier's disease in a Blaschkoid distribution and review the genetic implications of phenotypic mosaicism within the field of Darier's disease.
Linear and whorled nevoid hypermelanosis complicated with inflammatory linear verrucous epidermal nevus and ichthyosis vulgaris
Authors: LU Yan , ZHU Wen‐Yuan 
Published: October 2007

ABSTRACTWe report a 17‐year‐old girl who presented with linear and whorled melanosis following Blaschko lines mainly on her trunk. Ichthyosiform lesions and linear scaling erythemas were observed respectively on her lower limbs and the dorsa of her hands, left knee, ankle and foot. No abnormality was found in systemic examination and blood tests. A biopsy specimen of pigmentation of her back showed there was increased pigmentation within the basal keratinocytes, with focal incontinentia pigmenti. Notable lymphangiectasis could also be seen in the mid part of dermis, which had never previously been described. The biopsy of scaling erythemas of her hand showed dominant hyperkeratosis with focal parakeratosis, acanthosis and papillomatous hyperplasia in the epidermis. The diagnosis of linear and whorled nevoid hypermelanosis (LWNH) complicated with inflammatory linear verrucous epidermal nevus and ichthyosis vulgaris was made in accordance with clinical and pathological manifestations. LWNH ought to be differentiated from incontinentia pigmenti and hypomelanosis of Ito.
Spontaneous regression of recurrent and metastatic Merkel cell carcinoma
Authors: KUBO Hidemichi , MATSUSHITA Shigeto , FUKUSHIGE Tomoko , KANZAKI Tamotsu , KANEKURA Takuro 
Published: October 2007

ABSTRACTMerkel cell carcinoma (MCC) is a malignant neuroendocrine tumor with a high rate of recurrence and metastasis. Despite its high degree of malignancy, spontaneous regression has been documented. We report an 87‐year‐old woman who presented with recurrent MCC on her left cheek and regional lymph node metastasis. Although she received no treatment due to her poor condition, the recurrent metastatic lesion regressed spontaneously within 2 months.
Bowen's disease with high telomerase activity
Authors: NORO Sachiko , MITSUISHI Tsuyoshi , UENO Takashi , KANEKO Takehiko , NAKATAKE Mayuka , YAMADA Osamu , KAWANA Seiji 
Published: October 2007

ABSTRACTWe describe an 81‐year‐old Japanese woman who had a palm‐sized, erythematous plaque with a nodular lesion on the lateral abdomen. The biopsy specimens taken from the erythematous plaque and reddish nodule show that bowenoid changes were present in the epidermis and epidermis to dermis, respectively. A sentinel lymph node biopsy (SNB) was performed with blue dye and radioisotope in her right groin region and two lymph nodes were found to be occupied by many atypical cells. The erythematous plaque with nodular lesion was completely removed with a 3‐cm margin under general anesthesia, and complete regional lymph node dissection was also performed. In addition, high telomerase activity was seen in the erythema plaque while using a telomeric repeat amplification protocol assay. In conclusion, some instances of Bowen's disease might have high telomerase activity in the atypical cells and can progress to Bowen's carcinoma. The SNB was regarded as a useful method to detect early lymph node metastases in this case.
Sonodynamically‐induced apoptosis, necrosis, and active oxygen generation by mono‐l‐aspartyl chlorin e6
Authors: Yumita Nagahiko , Han Qing‐Song , Kitazumi Ikuko , Umemura Shin‐ichiro 
Published: October 2007

In this study, we investigated the induction of apoptosis by ultrasound in the presence of a photochemically active chlorine, mono‐l‐aspartyl chlorin e6 (NPe6). HL‐60 cells were exposed to ultrasound for up to 3 min in the presence and absence of NPe6, and the induction of apoptosis was examined by analyzing cell morphology, DNA fragmentation, and caspase‐3 activity. Cells treated with 80 µM NPe6 and ultrasound clearly showed membrane blebbing and cell shrinkage, whereas significant morphologic changes were not observed in cells exposed to either ultrasound alone, at the same intensity, or NPe6 alone. Also, DNA ladder formation and caspase‐3 activation were observed in cells treated with both ultrasound and NPe6 but not in cells treated with ultrasound or NPe6 alone. In addition, NPe6 substantially enhanced nitroxide generation by ultrasound in the same acoustical arrangement. Sonodynamically‐induced apoptosis, caspase‐3 activation, and nitroxide generation were significantly suppressed by histidine. These results suggest that the combination of ultrasound and NPe6 sonochemically induces apoptosis as well as necrosis in HL‐60 cells. They further suggest that some ultrasonically‐generated active species, deactivatable by histidine, are the major mediators to induce the observed apoptosis. (Cancer Sci 2008; 99: 166–172)
Use of linked loci as individuals or haplotypes for marker‐assisted breed assignment
Authors: Stella A. , Panzitta F. , Gandini G. , Boettcher P. J. 
Published: October 2007

SummaryThe objective of this study was to use simulation to evaluate the benefits of considering haplotypes of loci when linked single nucleotide polymorphisms are used for breed assignment. Three breeds of 10 000 females each were simulated under eight scenarios that differed according to the number of generations separating the breeds, size of breed founder populations and recombination rate between linked loci. Molecular genotypes consisted of 20 groups of three linked loci each. Breed assignment was performed in the final generation and was based on the frequency method. Haplotypes were reconstructed using the expectation–maximization algorithm. Accuracy of breed assignment was based on the frequency of correct breed assignment. Assignment accuracy increased as more genotypes (loci or haplotypes) were considered and more animals were used to estimate genotypic frequencies within breed. For most scenarios, use of haplotypes yielded equal or greater accuracies than when loci were considered independent. The advantage of haplotypes tended to increase as linkage disequilibrium between adjacent loci increased. The greatest advantage for using haplotypes was observed when recombination rate was low (0.001), breeds were separated by few generations (100), and a relatively large number of founder animals (110) was used to form new breeds. In this situation, 90% accuracy of breed assignment was achieved using nine to 14 haplotypes (i.e. 27–42 loci) depending on breed, vs. 39–57 individual loci.
New classification system for mass transport complexes in offshore Trinidad
Authors: Moscardelli Lorena , Wood Lesli 
Published: October 2007

ABSTRACTThis paper delineates our use of 10 708 km2 of three‐dimensional (3D) seismic data from the continental margin of Trinidad and Tobago West Indies to describe a series of mass transport complexes (MTCs) that were deposited during the Plio‐Pleistocene. This area, situated along the obliquely converging boundary of the Caribbean/South American plates and proximal to the Orinoco Delta, is characterized by catastrophic shelf‐margin processes, intrusive/extrusive mobile shales and active tectonism. Extensive mapping of different stratigraphic intervals of the 3D seismic survey reveals several MTCs that range in area from 11.3 to 2017 km2. Three types of MTCs are identified: (1) shelf‐attached systems that were fed by shelf‐edge deltas whose sediment input is controlled by sea‐level fluctuations and sedimentation rates; (2) slope‐attached systems, which occur when upper‐slope sediments catastrophically fail owing to gas‐hydrate disruptions and/or earthquakes and (3) locally detached systems, formed when local instabilities in the seafloor trigger relatively small collapses. Such classification of the relationship between slope mass failures and sourcing regions enables a better understanding of the nature of initiation, length of development history and petrography of such MTCs. 3D seismic enables more accurate calculation of deposit volumes, improves deposit imaging, and, thus, increases the accuracy of physical and computer simulations of mass failure processes.