bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of low‐energy, partially hydrolysed enteral formula on gastrointestinal symptoms and weight in children with neurological impairment: a multicentre retrospective study
Authors: O'Connor Graeme , Van Der Linde Martha , Capriles Zoltan Hartfiel 
Published: March 2024

AbstractBackgroundNeurological impairment (NI) relates to disorders of the central nervous system. The specific aetiology of NI varies but includes genetic, congenital abnormalities or brain injury. In children with severe NI, feeding impairments can lead to undernutrition, and some children require a feeding tube. Although tube feeding improves overall nutritional status, it has also been associated with excess body fat. Commercially available enteral formulas that are low in energy, hydrolysed and nutritionally adequate for protein and micronutrients are available to mitigate gastrointestinal symptoms and obesity.MethodsThis is a retrospective multicentre study of children who attended NI clinics between January 2022 and July 2023. Data were collected before and 1 month after receiving a low‐energy, partially hydrolysed enteral formula (0.6 kcal/mL) on demographic data (age, sex, ethnicity and NI diagnosis), anthropometric measurements (weight, height, weight‐for‐age Z‐score, height‐for‐age Z‐score, body mass index [BMI] Z‐score) and feed regimen (feed volume, total fluids and type of formula/supplements).ResultsDietitians collected data on 28 children, the median age was 7 years (interquartile range [IQR] 3, 8). The most frequently recorded NI was cerebral palsy, in 13 of 28 children (48%). Before the formula switch, the most frequently reported gastrointestinal symptom was constipation, in 13 of 28 children. Within 1 month of switching to a low‐energy, hydrolysed formula, 10 of the 13 (77%) children reported an improvement in constipation. Before the formula switch, all 28 children were experiencing excessive weight gain. After the formula was switched to low‐energy, hydrolysed formula, dietitians reported that 20 of the 28 (76%) children's weight either stabilised or reduced after 1 month. There was no statistically significant difference in weight‐for‐age Z‐score or BMI Z‐scores postswitch of formula (p‐value 0.1 and 0.09, respectively). Fibre intake increased significantly from 3.3 to 8.1 g/day (p‐value < 0.01) after formula switch. The number of children whose feed regimens were simplified after switching to a low‐energy, partially hydrolysed formula was 24 of 28 (91%).ConclusionsChildren with an NI who have gastrointestinal symptoms may benefit from a low‐energy, hydrolysed enteral formula to maximise feed tolerance and promote healthy weight gain. In addition, changing to a low‐energy, hydrolysed formula may simplify feed regimens by eliminating the need for additional electrolytes, multivitamins and fluid boluses. Healthcare professionals should be knowledgeable about the effectiveness and availability of a low‐energy, hydrolysed formula.
Microplasma radio frequency technology using stationary tips on pig skin: A histological study
Authors: Feng Jiayi , Ning Jiaxin , Zhang Ling , Li Xiaodan , Huang Lvping 
Published: March 2024

AbstractObjectiveTo investigate the histological properties of microplasma radiofrequency (MPRF) using a stationary tip in different treatment strategies on porcine skin.MethodsTwo Bama miniature pigs received MPRF treatment with two types of stationary tips in eight groups of parameters (power, duration, and pass) on dorsal skin. Skin samples were collected from each treatment zone immediately, at 1 week and 1, 3, and 6 months after treatment. Hematoxylin and eosin (HE) and Masson staining were performed to assess histologic changes as well as neocollagenesis. The dynamic changes of heat shock protein 47 (HSP47) and heat shock protein 72 (HSP72) were also detected by immunohistochemistry.ResultsSkin damage increased with pulse energy, duration, and pass. Longer durations or repeated treatments may cause particularly severe skin damage. During the wound healing process, the newborn collagen of the dermis is rearranged. The distribution of HSP47 and HSP72 was consistent with the extent of collagen remodeling. It peaked 1 month after treatment.ConclusionMPRF can effectively cause epidermal ablation, dermal collagen hyperplasia, and remodeling. Increasing power should be the first choice when increasing treatment intensity. For longer durations or repeated treatments, caution should be taken to avoid excessive skin trauma.
Influence of perceived peer behavior on engagement in self‐damaging behaviors during the transition to university
Authors: Hofer Marlise K. , Robillard Christina L. , Legg Nicole K. , Turner Brianna J. 
Published: March 2024

AbstractAs students transition to university, they experience significant social changes that can affect their behaviors, including self‐damaging behaviors like disordered eating, problematic alcohol/drug use, suicidal thoughts, and non‐suicidal self‐injury (NSSI). Building on prior work, we examined the associations between (1) perceptions of peers' engagement in self‐damaging behaviors predicting one's own subsequent engagement in such behaviors (i.e., socialization) and (2) one's own engagement in self‐damaging behaviors predicting perceptions of peers' subsequent engagement in such behaviors (i.e., selection). We also examined whether these associations were moderated by the source of influence (close peer/acquaintance) and degree of social disconnection experienced by the student. First‐year university students (N = 704) were asked to complete seven monthly surveys. Multilevel models indicated that when students perceived their close peers had engaged in NSSI or suicidal thinking, they had seven times greater odds of future engagement in the same behavior, implying that socialization increases the risk of these behaviors among university students. Perception of acquaintances' NSSI also predicted greater odds of a student's own NSSI the following month. Social disconnection increased the likelihood of matching own behaviors to perceptions of acquaintances' alcohol abuse, highlighting the importance of fostering connections/mentors to reduce self‐damaging behaviors on college campuses. Furthermore, when students engaged in alcohol abuse, they had almost four times greater odds of reporting that their acquaintances abused alcohol the following month, emphasizing the importance of the wider social network in alcohol use behaviors.
Considering Cuteness Enhances Smiling Responses to Infant Faces1,2
Authors: Nittono Hiroshi , Ohashi Akane 
Published: March 2024

AbstractLaboratory and field research has reported that the appearance of infants causes observers to smile. The current study examined whether this smiling response is modulated by the observer's task and evaluative dimension. Thirty‐nine young nulliparous women were asked to rate the cuteness or beauty levels of 6‐month‐old infants' faces using a 7‐point scale in different blocks. Facial electromyograms (EMGs) were recorded of participants' facial muscles related to both smiling (the zygomaticus major [ZM] and orbicularis oculi [OO]) and frowning (the corrugator supercilii [CS]). The results showed that cuteness and beauty ratings were highly correlated with each other (r = .90), indicating that these evaluations were based on similar attractiveness‐related physical features. Facial EMG responses on the smiling muscle sites, ZM and OO, increased significantly from the baseline when participants rated the faces' cuteness, and the responses were larger than when participants rated the faces' beauty. CS activity was not found to have any effect. The perceived cuteness level of the infant faces did not affect the facial EMG responses. Moreover, the magnitude of the smiling response was shown to be much smaller than that associated with voluntary smiling. These findings suggest that facial expressions while viewing infant faces do not exhibit a fixed pattern but are modulated by observers' tasks and that considering cuteness, which is based on more affective evaluations than beauty, can enhance smiling responses.
Pharmacokinetics of subcutaneous ketamine administration via the Omnipod® system in dogs
Authors: Colón Claudia , Early Peter , Muñana Karen , Olby Natasha , Mariani Christopher , Mancini Shelby , Fefer Gilad , Li Zhong , Briley Jessica , Bailey Kate , Lascelles Duncan , Messenger Kristen 
Published: March 2024

AbstractKetamine is an injectable anesthetic agent with analgesic and antidepressant effects that can prevent maladaptive pain. Ketamine is metabolized by the liver into norketamine, an active metabolite. Prior rodent studies have suggested that norketamine is thought to contribute up to 30% of ketamine's analgesic effect. Ketamine is usually administered as an intravenous (IV) bolus injection or continuous rate infusion (CRI) but can be administered subcutaneously (SC) and intramuscularly (IM). The Omnipod® is a wireless, subcutaneous insulin delivery device that adheres to the skin and delivers insulin as an SC CRI. The Omnipod® was used in dogs for postoperative administration of ketamine as a 1 mg/kg infusion bolus (IB) over 1 hour (h). Pharmacokinetics (PK) showed plasma ketamine concentrations between 42 and 326.1 ng/mL. The median peak plasma concentration was 79.5 (41.9–326.1) ng/mL with a Tmax of 60 (30–75) min. After the same infusion bolus, the corresponding norketamine PK showed plasma drug concentrations between 22.0 and 64.8 ng/mL. The median peak plasma concentration was 43.0 (26.1–71.8) ng/mL with a median Tmax of 75 min. The median peak ketamine plasma concentration exceeded 100 ng/mL in dogs for less than 1 h post infusion. The Omnipod® system successfully delivered subcutaneous ketamine to dogs in the postoperatively.
Nematodes alter the taxonomic and functional profiles of benthic bacterial communities: A metatranscriptomic approach
Authors: Guden Rodgee Mae , Haegeman Annelies , Ruttink Tom , Moens Tom , Derycke Sofie 
Published: March 2024

AbstractMarine sediments cover 70% of the Earth's surface, and harbour diverse bacterial communities critical for marine biogeochemical processes, which affect climate change, biodiversity and ecosystem functioning. Nematodes, the most abundant and species‐rich metazoan organisms in marine sediments, in turn, affect benthic bacterial communities and bacterial‐mediated ecological processes, but the underlying mechanisms by which they affect biogeochemical cycles remain poorly understood. Here, we demonstrate using a metatranscriptomic approach that nematodes alter the taxonomic and functional profiles of benthic bacterial communities. We found particularly strong stimulation of nitrogen‐fixing and methane‐oxidizing bacteria in the presence of nematodes, as well as increased functional activity associated with methane metabolism and degradation of various carbon compounds. This study provides empirical evidence that the presence of nematodes results in taxonomic and functional shifts in active bacterial communities, indicating that nematodes may play an important role in benthic ecosystem processes.
Adaptation and validation of the Physical Restraint‐Theory of Planned Behaviour Questionnaire to the paediatric context
Authors: Bosch Alcaraz Alejandro , Piqueras Rodríguez Pedro , Corrionero Alegre Jesús , García Piñero José Miguel , Belda Hofheinz Sylvia , Gil Domínguez Sonia , Zuriguel Pérez Esperanza , Luna Castaño Patricia , Saz Roy M. Ángeles , Martínez Oliva Marta , González Rivas Susana , Añaños Montoto Nerea , Espildora González María José , Martín‐Peñasco Osorio Elena , Carracedo Muñoz Eva , López Fernández Eduardo , Lozano Almendral Gema , Gomez Merino Alicia , Morales Cervera David , Fernández Lorenzo Rocío , Mata Ferro María , Martín Gómez Ainhoa , Serradell Orea Marta , Esquinas López Cristina , Via Clavero Gemma 
Published: March 2024

AbstractBackgroundPhysical restraint is applied in pediatric intensive care units to carry out certain painful procedures and to ensure the maintenance and continuity of life support devices. There is a need to analyse the factors that influence the behaviour or intention to use physical restraint.AimTo create and test psychometrically a paediatric version of the Physical Restraint‐Theory of Planned Behaviour Questionnaire to assess paediatric critical care nurses' intention to use physical restraint.Study DesignA psychometric study. Five medical‐surgical Paeditric Intensive care Units from five hospitals in Spain. The study took place in three phases. In phase 1, the questionnaire was adapted. In phase 2, the content validity of each item was determined, and a pilot test was conducted. In phase 3, we administered the questionnaire and determined its psychometric properties.ResultsThe assessment of the intention to use physical restraint was extended to all critical paediatric patients, two items were eliminated from the initial questionnaire, four new items were included, and the clinical scenarios of the intention subscale were expanded from three to six. Overall content validity index for the full instrument of 0.96 out of 1. The Paediatric Physical Restraint‐Theory of Planned Behaviour Questionnaire is made up of four subscales (attitude, subjective norms (SN), perceived behavioural control (PBC), and intention) subdivided into 7 factors and 51 items. The internal consistency for the attitude subscale obtained a Cronbach's Alpha of 0.80 to 0.73, for the SN it was 0.72 to 0.89, for the PBC it was from 0.80 to 0.73 and for the intention subscale it was 0.75.ConclusionsThe Paediatric Physical Restraint‐Theory of Planned Behaviour Questionnaire is an instrument composed of seven factors and 51 items that validly and reliably assesses the intention of paediatric nurses to apply PR in PICUs.Relevance for Clinical PracticeHaving this instrument will help health centres move towards restraint‐free care by allowing managers to assess professionals' attitudes, beliefs, and intentions around the use of PR in PICUs.
A phosphatase gene is linked to nectar dihydroxyacetone accumulation in mānuka (Leptospermum scoparium)
Authors: Grierson Ella R. P. , Thrimawithana Amali H. , van Klink John W. , Lewis David H. , Carvajal Ignacio , Shiller Jason , Miller Poppy , Deroles Simon C. , Clearwater Michael J. , Davies Kevin M. , Chagné David , Schwinn Kathy E. 
Published: March 2024

Summary

Floral nectar composition beyond common sugars shows great diversity but contributing genetic factors are generally unknown. Mānuka (Leptospermum scoparium) is renowned for the antimicrobial compound methylglyoxal in its derived honey, which originates from the precursor, dihydroxyacetone (DHA), accumulating in the nectar. Although this nectar trait is highly variable, genetic contribution to the trait is unclear. Therefore, we investigated key gene(s) and genomic regions underpinning this trait.

We used RNAseq analysis to identify nectary‐associated genes differentially expressed between high and low nectar DHA genotypes. We also used a mānuka high‐density linkage map and quantitative trait loci (QTL) mapping population, supported by an improved genome assembly, to reveal genetic regions associated with nectar DHA content.

Expression and QTL analyses both pointed to the involvement of a phosphatase gene, LsSgpp2. The expression pattern of LsSgpp2 correlated with nectar DHA accumulation, and it co‐located with a QTL on chromosome 4. The identification of three QTLs, some of the first reported for a plant nectar trait, indicates polygenic control of DHA content.

We have established plant genetics as a key influence on DHA accumulation. The data suggest the hypothesis of LsSGPP2 releasing DHA from DHA‐phosphate and variability in LsSgpp2 gene expression contributing to the trait variability.
Accommodative response and visual fatigue following a non‐congruent visual task in non‐asthenopic and asthenopic individuals
Authors: Coq Rémi , Neveu Pascaline , Plantier Justin , Legras Richard 
Published: March 2024

AbstractPurposeAsthenopia is related to near vision activities or visual tasks that dissociate accommodation from vergence. Since the results of previous studies using objective measures to diagnose asthenopia are inconsistent, this study compared optometric tests and objective metrics of accommodation in non‐asthenopic and asthenopic young adults before and after a visual fatigue task.MethodsThe accommodative response was recorded objectively for 6 min at a 3.33 D accommodative demand using an autorefractor, before and after a 5‐min non‐congruent visual task. Accommodation was disassociated from vergence with a ±2.00 D accommodative flipper while reading at the same distance. Optometric tests and subjective evaluations of asthenopia were performed before and after the task. Twenty‐six non‐presbyopic adults (23.15 ± 2.56 years) were included and identified as asthenopic (n = 14) or non‐asthenopic (n = 12) based on their score on the Computer Vision Syndrome Questionnaire.ResultsA mixed ANOVA found no significant difference between the groups for objective (accommodative response) or subjective metrics (feeling of fatigue, optometric tests), although all participants reported greater visual fatigue after the task. A significant effect of time (before and after the non‐congruent task) was identified for the overall sample for mean accommodative lag (+0.10 D, p = 0.01), subjective visual fatigue (+1.18, p < 0.01), negative relative accommodation (−0.20 D, p = 0.02) and near negative fusional reserve (blur: +2.46Δ, p < 0.01; break: +1.89Δ, p < 0.01; recovery: +3.34Δ, p = 0.02).ConclusionsThe task‐induced asthenopia, measured both objectively and subjectively, was accompanied by a change in accommodative lag, greater visual fatigue and a decrease in negative relative accommodation. Conversely, near negative fusional reserves seem to adapt to the task. No significant differences were found between the two groups with respect to accommodative metrics (objective) or subjective and optometric tests.
Comparison of red and green light for treating non‐muscle invasive bladder cancer in rats using singlet oxygen‐cleavable prodrugs with PPIX‐PDT
Authors: Rahman Kazi Md Mahabubur , Kumbham Soniya , Bist Ganesh , Woo Sukyung , Foster Barbara A. , You Youngjae 
Published: March 2024

AbstractIt has been 30 years since Photofrin‐PDT was approved for the treatment of bladder cancer in Canada. However, Photofrin‐PDT failed to gain popularity due to bladder complications. The PDT with red light and IV‐administered Photofrin could permanently damage the bladder muscle. We have been developing a new combination strategy of PpIX‐PDT with singlet oxygen‐cleavable prodrugs for NMIBC with minimal side effects, avoiding damage to the bladder muscle layer. PpIX can be excited by either green (532 nm) or red (635 nm) light. Red light could be more efficacious in vivo due to its deeper tissue penetration than green light. Since HAL preferentially produces PpIX in tumors, we hypothesized that illuminating PpIX with red light might spare the muscle layer. PpIX‐PDT was used to compare green and red laser efficacy in vitro and in vivo. The IC50 of in vitro PpIX‐PDT was 18 mW/cm2 with the red laser and 22 mW/cm2 with the green laser. The in vivo efficacy of the red laser with 50, 75, and 100 mW total dose was similar to the same dose of green laser in reducing tumor volume. Combining PpIX‐PDT with prodrugs methyl‐linked mitomycin C (Mt‐L‐MMC) and rhodamine‐linked SN‐38 (Rh‐L‐SN‐38) significantly improved efficacy (tumor volume comparison). PpIX‐PDT or PpIX‐PDT + prodrug combination did not cause muscle damage in histological analysis. Overall, a combination of PpIX‐PDT and prodrug with 635 nm laser is promising for non‐muscle invasive bladder cancer treatment.
Episodic imagining, temporal experience, and beliefs about time
Authors: Bigg Anthony , Latham Andrew J. , Miller Kristie , Yechimovitz Shira 
Published: March 2024

AbstractWe explore the role of episodic imagining in explaining why people both differentially report that it seems to them in experience as though time robustly passes, and why they differentially report that they believe that time does in fact robustly pass. We empirically investigate two hypotheses, the differential vividness hypothesis, and the mental time travel hypothesis. According to each of these, the degree to which people vividly episodically imagine past/future states of affairs influences their tendency to report that it seems to them as though time robustly passes and to judge that time does robustly pass. According to the former, a greater degree of vividness will tend to increase the extent to which people make such reports, while according to the latter, it will tend to decrease the extent to which people make such reports. We found weak evidence in favour of the former hypothesis. We reflect on the implications of this finding for theorising about such reports.
Keeping the magic alive: The multiple functions of magic concepts
Authors: Bentzen Tina Øllgaard , Siverbo Sven , Winsvold Marte 
Published: March 2024

AbstractDespite scholarly fascination with magic concepts, empirical research on how they fare in practice is scarce. This study explores how magic concepts retain their magic when used in public organizations. Using survey data and case studies, we identify “trust” as a magic concept in Scandinavian municipalities and develop a typology of its four central functions. We find that the concept of trust is used to confirm and confront old organizational practices, as well as to calibrate and catalyze new ones. We suggest that the multivocal character of magic concepts enables them to fit multiple agendas simultaneously, strengthening their ability to stay magic.
Groin injuries in women's premier league football in Norway: A two‐season prospective cohort study describing clinical and imaging characteristics
Authors: Thorarinsdottir Solveig , Amundsen Roar , Larmo Arne , Pedersen Roar , Andersen Thor Einar , Bahr Roald , Møller Merete 
Published: March 2024

AbstractObjectiveTo describe the prevalence, incidence, and burden of groin injuries in the Norwegian women's premier football league and to describe their clinical and imaging characteristics.MethodsDuring the 2020 and 2021 seasons, players in the Norwegian women's premier league reported groin injuries weekly, using the Oslo Sports Trauma Research Centre Questionnaire on Health Problems (OSTRC‐H2). We calculated weekly prevalence, incidence, and burden of groin injuries. The team physical therapists classified the player‐reported injuries based on the Doha classification system. Injuries with more than 3 days' time loss or reported in 2 consecutive weeks were eligible for magnetic resonance imaging (MRI).ResultsOn average, 3.9% (95% CI: 3.4–4.4) of players reported a groin injury at any time; of which 78% caused time loss. The incidence rate was 1.6 injuries/1000 h (95% CI: 1.3–2.0) and their burden was 11 days lost/1000 h. The physical therapists examined 67 of 124 player‐reported groin injuries (53%). Adductor‐related injury was most common (55%) followed by iliopsoas (15%) and rectus femoris‐related (12%). Pubic‐related injuries caused most time loss (median: 24 days, IQR: 5–133). In this study, 42 injuries were investigated with MRI; 8 (19%) showed no changes, 6 (14%) an acute musculotendinous lesion, and 32 (76%) a nonacute finding (e.g., central symphyseal disc protrusion, tendinopathies).ConclusionThe incidence rate and burden of groin injuries were high. Adductor‐related injuries were most common, but pubic‐related injuries caused most time loss. Most MRI examinations demonstrated nonacute findings.