bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-aging effect of glycerophosphocholine in Steinernema kraussei 0657L
Authors: Li Xi-Tong , Qian Xiu-Juan , Chen Hong , Wang Xing-Duo , Wu Xia 
Published: April 2024

Glycerophosphocholine (GPC) is a water-soluble small molecule found naturally in humans and foods such as milk and soybeans. It can activate the IIS pathway by regulating the expression of daf-2, ins-18 and daf-16 genes, sek-1 and skn-1 genes of MAPK pathway, sod-3, ctl-1, gst-4 and other antioxidant genes. GPC can relieve symptoms related to aging in organisms. The aim of this study was to probe the effects of GPC on the longevity and stress resistance of the entomopathogenic nematode (EPN) Steinernema kraussei 0657L strain. The results showed that the lifespan of S. kraussei 0657L was significantly prolonged by 50 mM GPC treatment, which was 54.55% longer than that of the control (0 mM GPC). GPC significantly inhibited reactive oxygen species (ROS) and lipofuscin accumulation, but the body size and fecundity of S. kraussei 0657L had little changed. At the same time, the longevity of S. kraussei 0657L exposed to heat shock and UV-B radiation was significantly prolonged than that with no external stress. GPC supplementation increased the activity of antioxidant enzymes and corresponding gene expression. Under treatment with 50 mM GPC, the activities of superoxide dismutase and catalase were increased by 1.90- and 4.13-fold, respectively, the expression of the sod-3 and ctl-1 genes was increased by 3.60- and 0.60-fold, respectively, and harmful reactive oxygen species were removed. In addition, the expression levels of the ins-18, skn-1, sek-1 and gst-4 genes related to the insulin/IGF-1 signaling pathway were upregulated 1.04-, 1.84-, 2.21- and 1.24-fold, respectively. These results indicate that GPC is mainly involved in the lifespan regulation of S. kraussei 0657L and plays an important role in resistance to external stress by activating the insulin/IGF-1 signaling pathway and downstream PI3K/MAPK kinase, creating a new idea for improving the commercial efficacy of S. kraussei. It also laid a theoretical foundation for its further efficient development and utilization in the field of biological control.
Genome-wide expression analysis of novel heat-responsive microRNAs and their targets in contrasting wheat genotypes at reproductive stage under terminal heat stress
Authors: Saroha Monika , Arya Aditi , Singh Gyanendra , Sharma Pradeep 
Published: April 2024

IntroductionHeat stress at terminal stage of wheat is critical and leads to huge yield losses worldwide. microRNAs (miRNAs) play significant regulatory roles in gene expression associated with abiotic and biotic stress at the post-transcriptional level.MethodsIn the present study, we carried out a comparative analysis of miRNAs and their targets in flag leaves as well as developing seeds of heat tolerant (RAJ3765) and heat susceptible (HUW510) wheat genotypes under heat stress and normal conditions using small RNA and degradome sequencing.Results and discussion A total of 84 conserved miRNAs belonging to 35 miRNA families and 93 novel miRNAs were identified in the 8 libraries. Tae-miR9672a-3p, tae-miR9774, tae-miR9669-5p, and tae-miR5048-5p showed the highest expression under heat stress. Tae-miR9775, tae-miR9662b-3p, tae-miR1120a, tae-miR5084, tae-miR1122a, tae-miR5085, tae-miR1118, tae-miR1130a, tae-miR9678-3p, tae-miR7757-5p, tae-miR9668-5p, tae-miR5050, tae-miR9652-5p, and tae-miR9679-5p were expressed only in the tolerant genotype, indicating their role in heat tolerance. Comparison between heat-treated and control groups revealed that 146 known and 57 novel miRNAs were differentially expressed in the various tissues. Eight degradome libraries sequence identified 457 targets of the differentially expressed miRNAs. Functional analysis of the targets indicated their involvement in photosynthesis, spliceosome, biosynthesis of nucleotide sugars and protein processing in the endoplasmic reticulum, arginine and proline metabolism and endocytosis. ConclusionThis study increases the number of identified and novel miRNAs along with their roles involved in heat stress response in contrasting genotypes at two developing stages of wheat.
Factors influencing depressive symptoms in Chinese female breast cancer patients: a meta-analysis
Authors: Zhang Qingyuan , Wu Gen , Chen Jianfei , Fang Kui , Liu Qianqian , Zhang Pan , Zhu Hongzhen , Zhang Chunhua 
Published: April 2024

ObjectiveTo systematically evaluate and explore the factors influencing depressive symptoms in female breast cancer patients in China through meta-analysis.MethodsRelevant data were retrieved from cross-sectional studies or cohort studies on depressive symptoms of Chinese breast cancer within the following databases: PubMed, Embase, Cohrane Library, Web of 105 Science, Database of Medical Literature (CBM), Wan Fang Data, CNKI, and VIP databases. The literature screening, data extraction and literature quality evaluation were performed by two researchers by carefully reading the title, abstract and full text, and meta-analysis was performed using Stata 1.5 software after extracting relevant data.ResultsFourteen papers were finally included, with a cumulative total of 3,071 people surveyed, and a total of 1,298 breast cancer patients were detected with depression, with a detection rate of depressive symptoms of 42.26%; meta analysis showed that age less than 40 years old, unmarried, less than undergraduate education, monthly income &lt;5,000 yuan, advanced breast cancer, radical breast cancer surgery, family history, living in rural areas, underlying disease stage and chemotherapy were associated with an increased incidence of depression in breast cancer patients.ConclusionThe detection rate of depressive symptoms in female breast cancer patients is high, and there is a need to strengthen depression-related psychological screening of breast cancer patients and provide them with individualized interventions to reduce the incidence of depression in breast cancer patients and to lower the level of depression already present in the patients.
The impact of environmental accidents on the green apparel purchase behavior of Generation Z
Authors: Liu Lixian , Zhang Wenwen , Li Hao , Zheng Zeyu 
Published: April 2024

IntroductionThis study examines the impact of environmental accidents on Generation Z’s purchase behavior towards green apparel, integrating the Theory of Planned Behavior and the Norm Activation Theory to conceptualize how different dimensions of environmental accidents influence consumer behavior.MethodsEmploying focus groups and questionnaires, this research captures data on Generation Z’s perceptions and behaviors towards green apparel in the context of environmental accidents. The collected data were analyzed using SPSS software, with structural equation modeling employed to test the research hypotheses.ResultsThe findings indicate that the scale (H12  = 0.545), the degree of suddenness (H18  = 0.357), nature of the effect (H14  = 0.295), and duration (H17  = 0.289) of environmental accidents significantly influence Generation Z’s awareness of consequences, behavioral attitudes, subjective norms, and perceived behavioral control regarding the purchase of green clothing. Notably, the scale of environmental accidents has a significant impact on perceived behavioral control, which in turn significantly affects Generation Z’s intention to purchase green apparel (H3  = 0.5).DiscussionThis study elucidates the impact of environmental accidents on Generation Z’s green apparel purchase intentions. The findings highlight Generation Z’s environmental awareness and social responsibility, influencing their purchasing decisions. This research offers practical insights for brands to enhance green marketing strategies, focusing on product quality, transparency, and consumer education to align with Generation Z’s values and expectations. Future research should explore additional factors affecting purchase behavior and strategies to bridge the intention-behavior gap.
A proven reoffending study of individuals managed under the multi-agency public protection arrangements (MAPPA) in England and Wales
Authors: Lundrigan Samantha , Mann Natalie , Specht David , Kamitz Lea C. 
Published: April 2024

IntroductionPast research into the effectiveness of multi-agency public protection arrangements (MAPPA) in reducing reoffending it limited. Thus, the current study aimed to evaluate proven reoffending patterns for MAPPA managed individuals.MethodsProven reoffending for 39,501 MAPPA managed individuals was investigated by (1) examining patterns in the timing and frequency of proven reoffending for MAPPA managed individuals; (2) examining 1-, 3-, and 5-year proven reoffending patterns of MAPPA managed individuals by MAPPA category, age, and gender; and (3) comparing crime harm levels and recall to custody for MAPPA managed individuals pre- and post-MAPPA adoption.ResultsTaken together, our findings show that proven reoffending rates for individuals managed under MAPPA are substantially lower than those reported in proven reoffending statistics for England and Wales.DiscussionOur results suggest that MAPPA is making a positive contribution to a managing individuals convicted of sexual and violent offenses. Additionally, our findings provide the best evidence to date that MAPPA management may also be effective at reducing less serious offenses which do not typically involve immediate removal from society. These findings are considered in light of their theoretical and practical implications while potential limitations and avenues for future research are outlined.
Exploring depressive symptom trajectories in COVID-19 patients with clinically mild condition in South Korea using remote patient monitoring: longitudinal data analysis
Authors: Sung Sumi , Kim Su Hwan , Kim Youlim , Bae Ye Seul , Chie Eui Kyu 
Published: April 2024

BackgroundDuring the height of the COVID-19 pandemic, the Korean government temporarily allowed full scale telehealth care for safety and usability. However, limited studies have evaluated the impact of telehealth by analyzing the physical and/or mental health data of patients with COVID-19 diagnosis collected through telehealth targeting Korean population.ObjectiveThis study aimed to identify subgroup of depressive symptom trajectories in patients with clinically mild COVID-19 using collected longitudinal data from a telehealth-based contactless clinical trial.MethodsA total of 199 patients with COVID-19 were accrued for contactless clinical trial using telehealth from March 23 to July 20, 2022. Depressive symptoms were measured using the patient health questionnaire-9 on the start day of quarantine, on the final day of quarantine, and 1 month after release from quarantine. Additionally, acute COVID-19 symptoms were assessed every day during quarantine. This study used a latent class mixed model to differentiate subgroups of depressive symptom trajectories and a logistic regression model with Firth’s correction to identify associations between acute COVID-19 symptoms and the subgroups.ResultsTwo latent classes were identified: class 1 with declining linearity at a slow rate and class 2 with increasing linearity. Among COVID-19 symptoms, fever, chest pain, and brain fog 1 month after release from quarantine showed strong associations with class 2 (fever: OR, 19.43, 95% CI, 2.30–165.42; chest pain: OR, 6.55, 95% CI, 1.15–34.61; brain fog: OR, 7.03, 95% CI 2.57–20.95). Sleeping difficulty and gastrointestinal symptoms were also associated with class 2 (gastrointestinal symptoms: OR, 4.76, 95% CI, 1.71–14.21; sleeping difficulty: OR, 3.12, 95% CI, 1.71–14.21).ConclusionThese findings emphasize the need for the early detection of depressive symptoms in patients in the acute phase of COVID-19 using telemedicine. Active intervention, including digital therapeutics, may help patients with aggravated depressive symptoms.
The predictors of voluntary participation in pulmonary tuberculosis screening program: a study in a suburban community of southern Thailand
Authors: Kongkamol Chanon , Chintrakul Apinya , Horsiritham Kanakorn , Kiranantawat Nantaka , Nirattisaikul Sitang , Sungsiri Jitpreedee , Sathirapanya Pornchai , Sathirapanya Chutarat , Boonma Koontidar , Chowwanapoonpohn Tuck , Nuiman Paradon , Supunthuchaikul Jekita , Chokthamangoon Nuttartham , Chintana Chalanthon , Suktaneekul Trithep , Watcharanimit Chananyu 
Published: April 2024

BackgroundThe health belief model (HBM), baseline health condition, and sociocultural factors impact the decision to participate in a tuberculosis screening program.MethodsThis cross-sectional and descriptive study was carried out among the “Kao Taew” community dwellers aged 18 years and above, who voluntarily underwent the provided pulmonary tuberculosis (PTB) screening by chest radiographs (CXRs). The level of individual HBM domain perception, attitudes toward PTB prevention, and regularity of PTB prevention practices by the participants were evaluated. The significantly associated or correlated factors such as demographic characteristics, individual HBM domain perception, and attitudes toward PTB prevention with the regularity of PTB prevention practices from the univariate analysis were further analyzed by multiple linear regression (p &lt; 0.05) to determine the independent significant predictors of PTB prevention practices.ResultsAmong 311 participants comprising 65% women, 57.9% aged ≥ 65 years and 67.2% had an underlying disease. The study participants had a high level of perception of HBM domains but a low level of perception of the barrier. In addition, a high level of attitudes toward PTB prevention and a high regularity of PTB prevention practices were found. A multiple linear regression analysis revealed that the perceived benefits of PTB screening [Beta = 0.20 (0.04, 0.36) p = 0.016] and acquiring underlying diseases [Beta = 1.06 (0.38, 1.73), p = 0.002] were significant predictors for PTB prevention practices, while belief in Islam was a reverse predictor [Beta = −0.84 (−1.47, −0.21), p = 0.010].ConclusionsThe level of perception of the individual domain of HBM, health status, and religious belief significantly predicted voluntary participation in PTB screening programs. Careful consideration by integration of the relevant health psychology, physical, and sociocultural factors is crucial for planning a health screening program.
Health care expenses impact on the disability-adjusted life years in non-communicable diseases in the European Union
Authors: Torres Margarida , Nunes Alcina , Martins João P. , Ferreira Pedro L. , Pimenta Rui 
Published: April 2024

BackgroundNon-communicable diseases are a global health problem. The metric Disability-Adjusted Life Years was developed to measure its impact on health systems. This metric makes it possible to understand a disease’s burden, towards defining healthcare policies. This research analysed the effect of healthcare expenditures in the evolution of disability-adjusted life years for non-communicable diseases in the European Union between 2000 and 2019.MethodsData were collected for all 27 European Union countries from Global Burden of Disease 2019, Global Health Expenditure, and EUROSTAT databases. Econometric panel data models were used to assess the impact of healthcare expenses on the disability-adjusted life years. Only models with a coefficient of determination equal to or higher than 10% were analysed.ResultsThere was a decrease in the non-communicable diseases with the highest disability-adjusted life years: cardiovascular diseases (−2,952 years/105 inhabitants) and neoplasms (−618 years/105 inhabitants). Health expenditure significantly decreased disability-adjusted life years for all analysed diseases (p &lt; 0.01) unless for musculoskeletal disorders. Private health expenditure did not show a significant effect on neurological and musculoskeletal disorders (p &gt; 0.05) whereas public health expenditure did not significantly influence skin and subcutaneous diseases (p &gt; 0.05).ConclusionHealth expenditure have proved to be effective in the reduction of several diseases. However, some categories such as musculoskeletal and mental disorders must be a priority for health policies in the future since, despite their low mortality, they can present high morbidity and disability.
Short-term side effects of BNT162b2 vaccine in primary care settings in Qatar: a retrospective study
Authors: Abdeen Sami , Abed Alah Muna , Al-Zaidan Manal , Mohamed Ibrahim Mohamed Izham , Abdulmajeed Jazeel , Al-Nuaimi Asma Ali , Al-Kuwari Mohamed Ghaith 
Published: April 2024

BackgroundDespite the established effectiveness of the BNT162b2 Vaccine, the novel technology demands careful safety monitoring. While global studies have explored its safety, local data remains limited and exhibits some variability. This study investigated short-term side effects among BNT162b2 vaccinated individuals in Qatar.MethodsA retrospective analysis was conducted using data extracted from the electronic health records of individuals aged 18 or older across 8 primary health centers who received either the first or second dose of the BNT162b2 vaccine during the period from December 23, 2020, to April 24, 2021. The proportions of individuals experiencing short-term side effects after each dose were calculated. Logistic regression and log binomial regression analyses were used to explore associations with the side effects.ResultsAmong 7,764 participants, 5,489 received the first dose and 2,275 the second, with similar demographics between the groups. After the first dose, 5.5% reported at least one local side effect, compared to 3.9% after the second, with a 1.4 times higher incidence after the first dose (RR 1.4, 95% CI 1.14–1.75) compared to the second. Systemic side effects after the second dose were 2.6 times more common than after the first (RR 2.6, 95% CI 2.15–3.14). Gender, nationality, history of prior COVID-19 infection, and obesity were significantly associated with side effects after the first dose, while age, gender, and nationality, were significant factors after the second dose.ConclusionThe rates of side effects following the BNT162b2 vaccine in Qatar were relatively low, with age, gender, nationality, previous infection, and obesity identified as significant predictors. These results emphasize the need for tailored vaccination strategies and contributes valuable insights for evidence-based decision-making in ongoing and future vaccination campaigns.
Outdoor artificial light at night exposure and gestational diabetes mellitus: a case–control study
Authors: Sun Qi , Ye Fang , Liu Jing , Yang Yang , Hui Qin , Chen Yuanmei , Liu Die , Guo Jianning , Wang Chao , Lv Di , Tang Lijuan , Zhang Qi 
Published: April 2024

ObjectiveThis study aims to explore the association between outdoor artificial light at night (ALAN) exposure and gestational diabetes mellitus (GDM).MethodsThis study is a retrospective case–control study. According with quantiles, ALAN has been classified into three categories (Q1-Q3). GDM was diagnosed through oral glucose tolerance tests. Conditional logistic regression models were used to evaluate the association between ALAN exposure and GDM risk. The odds ratio (OR) with 95% confidence interval (CI) was used to assess the association. Restricted cubic spline analysis (RCS) was utilized to investigate the no liner association between ALAN and GDM.ResultsA total of 5,720 participants were included, comprising 1,430 individuals with GDM and 4,290 matched controls. Pregnant women exposed to higher levels of ALAN during the first trimester exhibited an elevated risk of GDM compared to those with lower exposure levels (Q2 OR = 1.39, 95% CI 1.20–1.63, p &lt; 0.001); (Q3 OR = 1.70, 95% CI 1.44–2.00, p &lt; 0.001). Similarly, elevated ALAN exposure during the second trimester also conferred an increased risk of GDM (second trimester: Q2 OR = 1.70, 95% CI 1.45–1.98, p &lt; 0.001; Q3 OR = 2.08, 95% CI 1.77–2.44, p &lt; 0.001). RCS showed a nonlinear association between ALAN exposure and GDM risk in second trimester pregnancy, with a threshold value of 4.235.ConclusionOutdoor ALAN exposure during pregnancy is associated with an increased risk of GDM.
Recognition and inequalities in older adults' sexuality in Chile
Authors: Gómez-Urrutia Verónica , Gartenlaub Andrea , Tello-Navarro Felipe 
Published: April 2024

IntroductionThis paper explores older adults' perceptions on sexuality and affectivity in Chile, according to class and sex.MethodsThe study is based on computer-assisted telephonic interviews with people aged 60 and over, men and women (n = 481). Data were analyzed using chi-squared tests and binary logistic regressions.Results and discussionMaintaining an active sex life is important for older adults of both sexes, contradicting the commonsense view according to which the relevance allocated to sex decreases significantly with age. However, the data show significant differences in perceptions by sex, suggesting that gendered conceptions regarding sexuality are influential along the entire life cycle. There are also relevant differences according to class, revealing the inequalities present in the expression of sexuality in Chile.
Localized nitrogen supply facilitates rice yield and nitrogen use efficiency by enabling root-zone nitrogen distribution and root growth
Authors: Hu Ren , Ding Zijuan , Tian Yingbing , Cao Yuxian , Hou Jun , Wang Xuexia 
Published: April 2024

IntroductionLocalized nitrogen (N) supply affects rice N uptake by influencing N release, and few studies have examined the effects of root zone N distribution and root growth on rice yield under localized N supply (LNS).MethodsA two-year field experiment was conducted with six treatments: no N application, farmers’ fertilizer practice (FFP), and four LNS treatments, including two types of N fertilizer with urea (U) and controlled release urea (CRU) were mechanically side deep fertilized (SDF) or root zone fertilized (RZF) at 10  cm soil depth (US, UR, CRUS and CRUR treatments, respectively).ResultsCompared with FFP, the dry matter accumulation, N uptake, and yield of LNS increased by 27%, 21%, and 17%, respectively. For N fertilizer type, compared with U, the NH4+-N concentration, total root surface area, volume, average diameter, and root biomass of CRU were significantly increased by 50%, 43%, 53%, and 23%, respectively, which resulted in a significant increase in yield by 12%. Regarding the N application methods, the total surface area, volume, average diameter, and root biomass of SDF were significantly increased by 32%, 24%, 10%, and 25% compared with RZF, respectively. However, the NH4+-N under RZF was more stable and lasted longer, with a significant increase in NH4+-N concentration of 21% compared to the SDF. Moreover, CRUR increased yield, N agronomic use efficiency, and gross return by 3.15%, 5.62%, and 2.81%, respectively, compared to CRUS.ConclusionCRU should be selected as the recommended N fertilizer types, and the combination of CRU and RZF was the most effective choice for rice production.