bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ionic Liquid-promoted the Synthesis of Structurally Diverse Pyrans,
Pyran-annulated Heterocycles, and Spiropyrans
Authors: Banerjee Bubun , Kaur Manmeet , Priya Anu , Sharma Aditi , Singh Arvind 
Published: March 2024

Abstract:
During the last two decades, non-conventional solvents, especially various ionic
liquids, have been utilized as efficient reaction media as they can play a dual role as solvents
and promoters. The use of ionic liquids as a medium increases the efficiency of the
reactions due to their inherent features like high thermal stability, ability to act as a catalyst,
non-volatility, high polarity, reusability, ability to dissolve a large number of organic and
inorganic compounds, etc. Under this direction, various structurally diverse ionic liquids
have been employed as efficient reaction media for various organic transformations. On the
other hand, among many other important synthetic scaffolds, during the last two decades,
the synthesis of pyrans, pyran-annulated heterocyclic scaffolds, and spiropyrans have
gained huge attention as they possess a wide range of significant biological efficacies,
which include antibacterial, anticancer, antimycobacterial, antioxidant, xanthine oxidase inhibitory, etc. activities.
Almost every day, many new methods are being added to the literature related to synthesizing pyrans, pyran-
annulated heterocyclic scaffolds, and spiropyrans. Among many other alternatives, various ionic liquids
have also played an efficient role as promoters for synthesizing structurally diverse pyrans, pyran-annulated
heterocyclic scaffolds, and spiropyrans. In this review, we have summarized a large number of literature reported
during the last two decades related to the ionic liquid-promoted synthesis of pyrans, pyran-annulated heterocyclic
scaffolds, and spiropyran derivatives.
CXCL13-neutralizing Antibody Alleviate Chronic Skeletal Muscle Degeneration in a Mouse Model
Authors: Xie Zhongcheng , Yang Jimin , Jiao Chunmeng , Chen Hui , Ouyang Siyu , Liu Zhiyang , Hou Qin , Liu Jifeng 
Published: March 2024

Introduction:
Skeletal muscle degeneration is a common effect of chronic
muscle injuries, including fibrosis and fatty infiltration, which is the replacement of preexisting
parenchymal tissue by extracellular matrix proteins and abnormal invasive
growth of fibroblasts and adipocytes.

Method:
This remodeling limits muscle function and strength, eventually leading to
reduced quality of life for those affected. Chemokines play a major role in the
regulation of immunocyte migration, inflammation, and tissue remodeling and are
implicated in various fibrotic and degenerative diseases. In this study, we aimed to
investigate the role of the B-cell chemokine CXCL13 in the gastrocnemius muscle of
the Achilles tendon rupture model mouse. We hypothesize that CXCL13 may promote
fibrosis and aggravate skeletal muscle degeneration. We performed RNA sequencing
and bioinformatics analysis of gastrocnemius muscle from normal and model mice to
identify differentially expressed genes and signal pathways related to skeletal muscle
degeneration and fibrosis.

Results:
Our results show that CXCL13 is highly expressed in chronically
degenerating skeletal muscle. Furthermore, CXCL13-neutralising antibodies with
therapeutic potential were observed to inhibit fibrosis and adipogenesis in vivo and in
vitro.

Conclusion:
Our study reveals the underlying therapeutic implications of CXCL13
inhibition for clinical intervention in skeletal muscle degeneration, thereby improving
patient prognosis.
Another CCTA Incidental Finding: Case Report of an Idiopathic Pulmonary
Vein Pseudo-thrombosis
Authors: Bordon Abraham , Weg Noah , Miller Raphael , Leb Jay , Sokol Seth I , Guelfguat Mark 
Published: March 2024

Introduction::
While pulmonary vein filling defects on CT are typically considered diagnostic for thrombus, under certain circumstances, they can be artifactual
as a result of flow phenomena.

Case Presentation::
We report a case of a 53-year-old female with chest pain who was found to have filling defects in pulmonary vein branches on CCTA that were
initially treated as thromboses. However, follow-up cardiac MRI was negative for thrombi, and pseudo-thrombosis was therefore diagnosed.

Conclusion::
Pulmonary vein pseudo-thrombosis should be considered in the differential diagnosis of pulmonary vein filling defects.
Choc-Tadalafil Fusion: Unlocking Solubility and Taste Harmony with
β-CD-Infused Medicated Chocolate
Authors: Modi Chetna , Sinha Manobika , Thakkar Vaishali , Rana Hardik , Chavda Dipika 
Published: March 2024

Objective:
The primary limitations of tadalafil in treating erectile dysfunction are its low
solubility and unpleasant bitter taste, which ultimately result in inadequate patient adherence. The
present study aimed to develop and characterize a medicated chocolate formulation containing
Tadalafil and ß-CD (solubility enhancer) employing the concept of Design of Experiment (DoE) using
chocolate as a user-friendly excipient.

Methods:
An inclusion complex was formulated by incorporating the drug into ß-CD using the
kneading method for solubility improvement and also as a taste masker for Tadalafil. The ratio of
drug: ß-CD inclusion complex was selected based on a phase solubility study. The inclusion complex
was molded into a chocolate base and optimized using the DoE approach. Further, drug excipient
interaction was evaluated by DSC and FTIR study.

Results:
Phase solubility study suggested a 1:1 ratio of Tadalafil: β-CD for better solubility. DSC
spectra suggested the conversion of crystalline structure into an amorphous state which indicates
improvement of the drug solubility. DSC and FTIR studies revealed that there was no significant
interaction between drug and excipients. Next, %CDR (cumulative drug release) at 30 min revealed
the immediate effect of Tadalafil from chocolate formulation and free drug analysis (an unbound
drug with ß-CD) proved reduced bitterness of the drug in the complex. Additionally, the medicated
chocolate was found to be stable at room temperature as per stability study.

Conclusion:
β-CD was found to be a promising multifunctional excipient as a solubility enhancement
carrier and taste masker for bitter-tasting drugs.
Shanxi Local Opera and Malaysian Chinese Opera Clothing Fabrics
Authors: Xing Furong , Azian Tahir  , Syed Alwi Syed Abu Bakar  , Ge Shuqian 
Published: March 2024

This paper, literature research, and comparative research were used to systematically study the costumes and fabrics. The paper finds that the clothing fabrics of Shanxi local opera have the magnificence of ancient Chinese costumes, and the process technology is mainly color embroidery, gold embroidery, and mixed embroidery. The fabrics of Malaysian Cantonese opera costumes are relatively more luxurious, with a very obvious Lingnan style. In the end, the article argues that historical and cultural changes have dominated the differentiation of fabrics. The research can further promote the theoretical and practical exploration of the intrinsic value of theatrical costumes.
PENERAPAN MODEL PEMBELAJARAN KONTEKSTUAL MELALUI VIDEO PEMBELAJARAN UNTUK MENINGKATKAN HASIL BELAJAR IPAS
Authors: E.A.R. Putri  , A.T. Widiansyah  
Published: March 2024

Penelitian ini bertujuan untuk meningkatkan hasil belajar IPAS siswa dengan menerapkan model pembelajaran kontekstual melalui video pembelajaran. Penelitian ini dilakukan di kelas X APHP SMK Negeri 2 Bagor Tahun Ajaran 2023/2024, dengan jumlah responden 32 siswa. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK). Objek penelitian adalah hasil belajar siswa. Teknik pengumpulan data menggunakan observasi, test dan dokumentasi. Penelitian dinyatakan tuntas manakala hasil belajar mencapai 80% dari keseluruhan siswa, artinya apabila 26 dari 32 siswa mendapatkan hasil belajar sama dengan atau di atas KKM 70, maka penelitian dianggap berhasil. Hasil penelitian menunjukkan bahwa melalui video pembelajaran: 1) pada pretest, siswa tuntas sebanyak 31,25% dengan nilai rata-rata 64, 2) pada postest sebanyak 84,37% siswa tuntas dengan nilai rata-rata 74. Hal ini menunjukkan bahwa penerapan video pembelajaran dapat meningkatkan hasil belajar IPAS kelas X SMKN 2 Bagor.
DESAIN DAN UJI COBA E-LKPD BERBASIS INTRODUCTION CONNECT APPLY REFLECT EXTEND (ICARE) PADA MATERI LARUTAN ELEKTROLIT DAN NON ELEKTROLIT
Authors: Arwina Tika , Okmarisa Heppy 
Published: March 2024

This research was instigated by the lack of available teaching material that was appropriate with student need—a teaching material connected the concept implementation to daily life. This research aimed at designing valid ICARE based electronic student workbook on Electrolyte and non-Electrolyte Solution lesson based on the validation by media and material experts, the teacher and student practicality tests. It was Research and Development (R&D) with Borg and Gall development design, and the steps were (1) researching and collecting information, (2) planning, (3) developing the initial form of the product, and 4) preliminary field testing, and (5) revising the product. Preliminary field testing was conducted to the eleventh-grade students of MIPA at State Senior High School located in Kampar district. The validation result by media and material experts showed that the score was 94.13% with very valid criterion. Teacher practicality test showed that the result was 93.63% with very practical category, and student practicality test showed that the result was 84.54% with very practical category.
Persepsi Mahasiswa Pendidikan Kimia UNIKS Terhadap Efektivitas Pembelajaran Online di Era Pandemi Covid-19
Authors: Murwindra Rosa 
Published: March 2024

Tujuan penelitian ini adalah untuk melihat persepsi mahasiswa pendidikan kimia Univesitas Islam Kuantan Singingi (UNIKS) terhadap efektivitas pembelajaran online di Era Pandemi Covid-19. Penelitian ini merupakan jenis penelitian kombinasi (Mixed Methods) kualitatif dan kuantitatif. Data dan informasi dikumpulkan melalui kuisioner (angket). Populasi pada penelitian ini adalah mahasiswa Prodi Pendidikan Kimia semester 2, 4 dan 6 Tahun Akademik 2021/2022. Adapun teknik pengambilan sampel menggunakan teknik random sampling. Data dianalisisis secara deskriptif dari kuisioner dengan menyusun tabel distribusi dan menampilkan data dalam bentuk diagram. Teknik analisis data menggunakan milik Milles dan Huberman. Hasil penelitian menunjukkan bahwa 48% setuju (S) dilakukan pembelajaran online karena dosen menggunakan metode pembelajaran yang bervariasi, 48% setuju (S) pembelajaran online dapat memperluas pengetahuan karena memanfaatkan internet untuk mencari informasi tentang pembelajaran, 48% setuju (S) pembelajaran online dilakukan saat adanya pandemi covid-19, 48% setuju (S) dalam pembelajaran online mahasiswa tetap mengerjakan tugas secara mandiri, 39% Setuju (S) pembelajaran online membutuhkan biaya yang banyak untuk membeli kuota, sehingga dapat disimpulkan bahwa persepsi mahasiswa terhadap pembelajaran online di era pandemic covid-19 sangat bervariasi dan mendapat respon positif dari mahasiswa. Keywords: Pandemi Covid-19, Pembelajaran online, Persepsi mahasiswa
Pengembangan Media Pembelajaran Berbasis Web Google Sites Pada Materi Reaksi Redoks Terintegrasi Nilai Islam
Authors: Fah Selly 
Published: March 2024

This research was instigated with the aim of education that is to form students who are devout, knowledgeable, independent, and who have religious morals. Apart from that, there is a lack of learning media use utilizing digital technology so that learning is less varied. This research aimed at developing Web Google Sites based learning media focusing on Islamic Values Integrated Redox Reactions lesson and linking two sciences into one complete unit. DDR (Design and Development Research) model was used in this research. Feasibility test was done by distributing validation sheet to media experts, material experts, and integration experts, conducting practicality test by Chemistry subject teachers, and distributing student response questionnaire. The result of Web Google Sites based learning media was stated feasible, if it was valid and practical, a) the validity percentages obtained were 92.5% (very valid) by media expert validators, 90% (very valid) by material expert validators, and 90.6% (very valid) by integration expert validators; b) practicality percentage of Chemistry subject teacher assessment through practicality test was 100% (very practical); and c) the percentage of student response to the media was 87.33% with very good criteria. Based on these results, it could be identified that Islamic Values integrated Web Google Sites based learning media on Redox Reactions lesson was valid and practical, so it could be used in the learning.
Karakteristik Pasien Adenomiosis dengan Gambaran Ultrasonografi di Rumah Sakit Dr. Hasan Sadikin Bandung Periode 2015-2016
Authors: Fitrina Meice , Bayuaji Hartanto , Madjid Tita Husnitawati , Armawan Edwin 
Published: March 2024

Abstrak Tujuan: Karakteristik pasien dan hasil pemeriksaan ultrasonografi penting untuk menegakkan diagnosis adenomiosis, dapat diketahui terkait dari usia, gejala dan paritas serta pemeriksaan patologi anatomi. Metode: Deskriptif retrospektif menganalisis gejala klinis dan ultrasonografi adenomiosis. Data demografi (usia dan paritas), gejala klinis, hasil pemeriksaan ultrasonografi, dan hasil pemeriksaan patologi anatomi.Hasil: Dari 116 kasus, rata-rata usia adalah 39 tahun, paritas 1 - 4 (51,7%), infertilitas sekunder (35,3%), dengan gejala klinis yang terbanyak adalah massa pada abdomen (45,7%). Hasil pemeriksaan ultrasonografi yang terutama adalah miometrium heterogen (63,8%), kista miometrium (59,5%), dan subendometrial linear striae (56,0%). Diskusi: Hasil pemeriksaan USG transvaginal yang paling banyak ditemukan gambaran miometrium heterogen (63,8%) dan kista miometrium (59,5%). Kesimpulan: Adenomiosis umum terjadi pada usia reproduktif dan multiparitas dengan gejala utama massa pada abdomen dan hasil ultrasonografi yang terutama ditemukan adalah miometrium heterogen. Characteristics Overview of Adenomyosis Patients with Ultrasonographic at Dr. Hasan Sadikin Bandung General Hospital during 2015–2016Abstract Objective: Characteristic patient and ultrasonography findings are important to make a diagnosis of adenomyosis. To describe common and uncommon characteristics patients which is include age, symptoms, and parity with ultrasonographic findings and histopatolgic examination of adenomyosis.Method: This study was a descriptive restrospective study in adenomyosis cases. Patients with clinical symptoms and confirmed with ultrasonographic was an adenomyosis were analyzed. Results: Out of 116 cases, mean age was >35 years old (70,7%), parity was 1 - 4 (51,7%), related to secondary infertility (35,3%), with most common symptom is abdominal mass (45,7%). Most common findings of ultrasonographic were heterogenous myometrium (63,8%), myometrium cyst (59,5%), and subendometrial linear striae / shadowing (56,5%).Discussion: Sign transvaginal ultrasound were the heterogeneous myometrium (63.8%) and myometrial cyst (59.5%). Conclusion: Adenomyosis usually happen in reproductive age, multiparity with main symptoms is abdominal mass and the most common sonographic findings is heterogenous myometrium.Key words: adenomyosis, ultrasonographic, transvaginal ultrasonography.
Personalized Medicine dalam Pelayanan Kesehatan Reproduksi
Authors: Martaadisoebrata Djamhoer 
Published: March 2024

AbstrakTujuan: Untuk mencoba mencari kejelasan kelemahan dan keunggulan berbagai paradigma dan mencoba membuktikan bahwa Personalized Medicine itu adalah paradigma yang terbaik, sampai saat ini.Metode: Studi PustakaHasil: Dengan seiring waktu Clinical Medicine juga mendapatkan tambahan pengembangan dari Evidence Based Medicine dan Genome Medicine. Personalized Medicine lebih mengembangkan ilmu kedokteran sesuai dengan individu masing-masing sehingga menjadi lebih baik.Kesimpulan: Walaupun terbukti bahwa Clinical Medicine, Evidence Based Medicine dan Genome Medicine mempunyai kelemahan di samping keunggulannya masing-masing, tetapi ketiga paradigma tersebut masih bisa digunakan, pada kondisi dan dan situasi tertentu. Personalized Medicine, sampai saat ini, masih yang terbaik, karena dalam pelaksanaannya terungkap sifat yang Holistik, Humanistik dan penuh Empati. Dengan perkataan lain, dokter yang melaksanakan pelayanan ini telah menjalankan kewajibannya dengan baik, berupa CURE dan CARE secara proporsional, suatu sifat yang bisa membuktikan keprofesionalannya.Kata kunci: Personalized medicine, pelayanan kesehatan dan kesehatan reproduksi. Personalized Medicine in Reproductive Health ServiceAbstractsObjectives: To look for any weakness and superiority for each of those paradigms and try to prove that Personalized Medicine is the best method in health service, until today.Method: Literature reviewResult: Developing clinical medicine also followed by Evidence Based Medicine and Genome Medicine other wise personalize medicine developing medical practice individuality to be better.Conclusion: Although we know Clinical Medicine, Evidence Based Medicine and Genome Medicine have some weaknesses, we also believe that those paradigms still can be used in certain conditions and situations. Mean while Personalized Medicine, until present time, is still the best method, because during its implementation, it describes its characteristic of Holistic, Humanism and full of Empathy. In other words, a physician who acts this way, is performing his obligation in the form of CURE and CARE, proportionally, an effort that can be considered as a sign of his professionalism.Key word: Personalized Medicine, health service and reproductive health.
Severe Preeclampsia at 26 weeks gestation on Nulliparous with complication of Bilateral Serous Retinal Detachment
Authors: Septiani Winty , Defri Defri , Emputri Obdes Maharani 
Published: March 2024

Preeclampsia is still one of the leading causes of death and severe maternal morbidity. The rate of incidences range from 5 to 10 % in all pregnancies. Clinical condition in Preeclampsia is increasing blood pressure and proteinuria. Preeclampsia can cause multisystem disorders including visual disruptions. The incidence rate of visual system disruptions is 25 % of patients with severe preeclampsia and 30% of patients with eclampsia. The most common visual complication is hypertensive retinopathy, serous retinal detachment, and cortical blindness. The incidences of serous retinal detachment are approximately 1% in severe preeclampsia and 10% in eclampsia. We report a case of 28 years old nulliparous with severe preeclampsia at 26 weeks gestation, who complained blurred vision, we ran several examinations and bilateral serous retinal detachment was diagnosed. Her visual has significant improvement a few weeks after pregnancy termination.Abstrak Preeklampsia masih menjadi salah satu penyebab utama kematian dan morbiditas maternal.[1] Tingkat insiden preeklampsia berkisar dari 5 hingga 10% pada semua kehamilan.[2] Kondisi klinis Preeklampsia adalah meningkatnya tekanan darah dan proteinuria. Preeklamsia dapat menyebabkan gangguan multisistem termasuk gangguan penglihatan.[3] Tingkat kejadian gangguan sistem penglihatan adalah 25% pada pasien dengan preeklampsia berat dan 50% pada pasien dengan eklampsia.[3] Komplikasi visual yang paling umum terjadi adalah retinopati hipertensi, serous retinal detachment, dan kebutaan kortikal.[4] Insidensi serous retinal detachment sekitar 1% pada preeklampsia berat dan 10% pada eklampsia.[5] Kami melaporkan kasus nulipara berusia 28 tahun dengan preeklamsia berat pada usia kehamilan 26 minggu, yang mengeluhkan penglihatan kabur, dilakukan beberapa pemeriksaan dan bilateral serous retinal detachment ditegakkan. Penglihatan pasien mengalami perbaikan yang signifikan minggu ke-lima setelah terminasi kehamilan.
Pelvic Inflammatory Disease (PID) Management in Corona Virus Disease 2019 (COVID-19) Pandemic Era
Authors: Winata I Gde Sastra , Taufiq Musa 
Published: March 2024

Objective: This article aims to review pelvic inflammatory disease management during the coronavirus disease 2019 pandemicMethod: We conducted a search for scientific articles through PubMed and Google Scholar, using the terminologies of “PID AND COVID-19”, “Pelvic Inflammatory Disease”; “Pelvic Inflammatory Disease AND COVID-19”, “PID Management AND COVID-19”, “Pelvic Inflammatory Disease Management AND COVID-19”, and “PID AND Pandemic” in English and Indonesian from 2019-2020.Result: There were a total of 25 scientific articles from PubMed and Google Scholar within 2019-2020 that were included as the source of this reviewConclusion: There is no difference between the management of pelvic inflammatory disease during and before the pandemic. The mode of medical services and follow up tends to be conducted virtually. Technology-based services for pelvic inflammatory disease during the corona virus disease 2019 pandemic are promising and have been proven to be an effective method, therefore virtual-based pelvic inflammatory disease services may be safely applied. However, if there is any indication of emergency found during the telemedicine services, a face-to-face consultation or emergency room visit should be recommended.Key words : COVID-19, Pelvic Inflammatory Disease, SARS-CoV-2Tatalaksana Radang Panggul selama Era Pandemi Virus Corona 2019 (COVID-19)AbstrakTujuan: Melakukan kajian mengenai tatalaksana dari penyakit radang panggul selama pandemi penyakit coronavirus 2019Metode: Kami melakukan pencarian artikel ilmiah melalui PubMed dan Google Scholar menggunakan terminologi “PID AND COVID-19”, “Pelvic Inflammatory Disease”; “Pelvic Inflammatory Disease AND COVID-19”, “PID Management AND COVID-19”, “Pelvic Inflammatory Disease Management AND COVID-19”, and “PID AND Pandemic” dalam Bahasa Inggris dan Indonesia dari tahun 2019-2020. Hasil: Ditemukan sebanyak 25 publikasi ilmiah dari pencarian di PubMed dan Google Scholar pada tahun 2019- 2020 yang digunakan sebagai sumber kajian ilmiah ini.Kesimpulan: Tatalaksana penyakit radang panggul sebelum dan selama pandemi tidak berubah. Metode pelayanan kesehatan dan follow up cenderung dilakukan secara virtual. Pelayanan kesehatan berbasis tekonologi untuk penyakit radang panggul selama pandemi penyakit coronavirus 2019 menjanjikan dan telah terbukti sebagai metode yang efektif, sehingga pelayanan kesehatan untuk penyakit radang panggul secara virtual dapat diaplikasikan secara aman. Jika ditemukan adanya indikasi kegawatdaruratan selama pelayanan telemedicine, pasien sebaiknya melakukan konsultasi tatap muka atau mengunjungi instalasi gawat darurat. Kata kunci: COVID-19, penyakit radang panggul, SARS-CoV-2