bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrochemical C(sp3)−H Functionalization Using Acetic Acid as a Hydrogen Atom Transfer Reagent
Authors: Morii Yuma , Watanabe Taito , Saga Yutaka , Kambe Tetsuya , Kondo Mio , Masaoka Shigeyuki 
Published: April 2024

AbstractIn this study, we developed a novel electrochemical protocol that enables the functionalization of inherently inert C(sp3)−H bonds. In this protocol, one‐electron oxidation of acetic acid was used to successfully generate methyl radical, which cleaves the benzylic C(sp3)−H bonds of the substrates via a hydrogen atom transfer (HAT) process, and further reaction with the formed species yields the targeted C(sp3)−H functionalized products. To the best of our knowledge, this is the first example of the use of acetic acid in a HAT process. Notably the reaction has environment‐friendly and fine atom economy nature: the reaction is driven by the electrochemical conditions in the absence of expensive or hazardous reagents, producing only gaseous small molecules, hydrogen, carbon dioxide, and methane, as side products.
A Vision for LLZO Carbonate Formation: Perspectives on Surface Treatment Approaches and Characterization Techniques
Authors: Ghorbanzade Pedram , López‐Aranguren Pedro , López del Amo Juan Miguel 
Published: April 2024

AbstractLi7La3Zr2O12 garnets are among the most promising materials for solid‐state electrolytes thanks to their high electrochemical stability and ionic conductivity. However, they are unstable in air and easily undergo a Li+/H+ exchange reaction, forming a lithiophobic and poorly Li‐conducting surface layer composed of LiOH and Li2CO3 upon further reaction with CO2. Despite a simple reaction mechanism, protonation of LLZO is a complex phenomenon. The thickness and composition of the secondary phases on the surface depend on many parameters both in the LLZO properties and in the storage atmosphere. Due to this complexity, proposing a universal procedure for removing the secondary phases is not simple. However, understanding the role of different parameters and rational selection of characterization techniques makes it possible to find the optimal conditions for removing the LiOH/Li2CO3 layer and further processing each material. This work compares some of the main approaches for cleaning the LLZO surface and describes their advantages and shortcomings. Additionally, the strengths and limitations of the most common characterization techniques for analyzing the (de)protonation of LLZO (XRD, XPS, Raman, NMR, TGA) are explained to help researchers design their experiments more accurately.
Synergistic effects of graphene quantum dots nanocarriers and folic acid targeting agent on enhanced killing of breast cancer cells by tamoxifen
Authors: Ghanbari Narges , Fam Ashkan Mohammadali , Salehi Zeinab , Khodadadi Abbas Ali , Safarian Shahrokh 
Published: April 2024

AbstractIn this study, a new targeted and controlled‐release drug delivery system based on graphene quantum dots (GQDs) was fabricated. The fluorescent GQDs were synthesized via an environmentally‐friendly chemical oxidation method, using graphene oxide (GO) as a precursor and hydrogen peroxide and ammonia solution as oxidants. Folic acid (FA), as a targeting agent, was bound to GQDs through strong amide covalent bindings, and tamoxifen (TMX), as a hydrophobic anticancer drug, was non‐covalently attached to the nanocarrier via π–π stacking bonds. The as‐prepared GQDs and TMX/FA‐GQDs were characterized using field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), UV/Vis spectroscopy (UV/Vis), and photoluminescence spectroscopy (PL). The resulting TMX/GQDs demonstrated pH‐sensitive release behaviour with an overall release of 85% and 58% at pH 5.5 and 7.4, respectively, after 120 h. Also, the MTT assay test performed on MCF‐7 cells presented negligible toxicity of the nanocarriers, even at high concentrations. At the same time, the targeted nanocarrier, TMX/FA‐GQDs, showed much more toxicity towards MCF‐7 cells than the non‐targeted one and free TMX.
Controlling the Reactivity of IBA‐N3 by Switching Halogen Salts: Providing a Universal Strategy for Haloazidation of Alkenes
Authors: Xia Chen‐Xi , Sun Xin‐Lei , Zhang Jinfeng , Ren Yue , Yu Yan , Wang Kuai , Meng Ling‐Guo 
Published: April 2024

Comprehensive SummaryAlthough various routes have been reported for haloazidation, unavoidable problems exist, such as environmentally unfriendly monomer halogen, the need for in situ generation of unstable halogen azides (XN3), applicability to one type of haloazidation and inability to precisely control selectivity. Herein, we developed a universal strategy for haloazidation of alkenes through controlling the reactivity of IBA‐N3 by switching halogen salts, allowing for the synthesis of a diversity of halogen azide products. Mechanistic studies have shown that by tuning the reactivity of IBA‐N3 via switching halogen salts, different intermediates can be controllably produced to achieve regioselectivity and chemoselectivity in the haloazidation of alkenes.
Family characteristics and childcare patterns associated with early social functioning in cancer‐bereaved parents
Authors: Snaman Jennifer M. , Chen Li , Mazzola Emanuele , Helton Gabrielle , Feifer Deborah , Broden Elizabeth , McCarthy Sarah , Rosenberg Abby R. , Baker Justin N. , Wolfe Joanne 
Published: April 2024

AbstractBackgroundBereaved parents experience life‐long grief after the death of their child from cancer. Parents who can integrate their grief and maintain their social functioning early in bereavement, even in the setting of concurrent psychosocial distress, have improved outcomes. Identifying the factors associated with bereaved parents' early social functioning can guide future supportive interventions.MethodsThe authors surveyed parents of children who died from cancer at two large centers 6–24 months after death, assessing bereavement experiences using validated and pilot tested tools. Univariable and multivariable logistical regression models were used to examine which family and child demographic, treatment, and end‐of‐life (EOL) factors were associated with maintained parental social functioning (T scores ≥40 on the Patient‐Reported Outcomes Measurement Information System Ability to Participate in Social Roles and Activities‐Short Form questionnaire).ResultsOne hundred twenty‐eight parents of 88 children participated (38% household response rate); most parents identified as female (63%) and White (88%). Parents' median age was 47 years (interquartile range, 10 years); and the median time from the child's death to survey completion was 13 months (interquartile range, 10 months). In multivariate modeling, parents without household material hardship and those who felt prepared for EOL circumstances had increased odds of maintained social functioning (odds ratio, 4.7 [95% confidence interval, 1.6–13.7; p < .004] and 5.5 [95% confidence interval, 1.9–15.9; p < .002], respectively).ConclusionsParents who felt prepared for their child's EOL and those without household material hardship were more likely to have maintained social functioning in the first 2 years after their child’s death. Interventions targeting EOL preparedness and alleviating household material hardship may improve bereavement outcomes.
Justice in the balance: The crucial role of disclosure in ensuring justice in Jordanian arbitration
Authors: Tarawneh Mosleh A. , Alhasan Tariq K. 
Published: April 2024

AbstractAs an alternative to traditional court litigation, arbitration has gained prominence in Jordan's legal landscape for its distinct attributes like speediness, confidentiality, autonomy, and efficiency. Central to the sanctity of this mechanism is the arbitrator's duty of disclosure, ensuring that the arbitration process remains impartial, transparent, and devoid of any potential bias. This paper explores the profound significance of the duty of disclosure in Jordan by analyzing the latest Jordanian Court of Cassation Decision No. 1479 of 2023, where nondisclosure by the Arbitral Tribunal led to the annulment of the arbitral award. Through juxtaposing international arbitration norms and thoroughly examining Jordanian legislation, this study underscores the consequences of nondisclosure and the paramount importance of transparency in arbitration. The insights drawn from this case reaffirm that the foundation of arbitration's credibility and trustworthiness rests on the rigorous adherence of arbitrators to disclosure, ensuring that justice is not only served but is transparently perceived.
Extending the phenotypic spectrum assessed by the CDR plus NACC FTLD in genetic frontotemporal dementia
Authors: Samra Kiran , Peakman Georgia , MacDougall Amy M. , Bouzigues Arabella , Greaves Caroline V. , Convery Rhian S. , van Swieten John C. , Jiskoot Lize , Seelaar Harro , Moreno Fermin , Sanchez‐Valle Raquel , Laforce Robert , Graff Caroline , Masellis Mario , Tartaglia Maria Carmela , Rowe James B. , Borroni Barbara , Finger Elizabeth , Synofzik Matthis , Galimberti Daniela , Vandenberghe Rik , de Mendonça Alexandre , Butler Chris R. , Gerhard Alexander , Ducharme Simon , Ber Isabelle Le , Tiraboschi Pietro , Santana Isabel , Pasquier Florence , Levin Johannes , Otto Markus , Sorbi Sandro , Rohrer Jonathan D. , Russell Lucy L. ,    Genetic FTD Initiative (GENFI)
Published: April 2024

AbstractINTRODUCTIONWe aimed to expand the range of the frontotemporal dementia (FTD) phenotypes assessed by the Clinical Dementia Rating Dementia Staging Instrument plus National Alzheimer's Coordinating Center Behavior and Language Domains (CDR plus NACC FTLD).METHODSNeuropsychiatric and motor domains were added to the standard CDR plus NACC FTLD generating a new CDR plus NACC FTLD‐NM scale. This was assessed in 522 mutation carriers and 310 mutation‐negative controls from the Genetic Frontotemporal dementia Initiative (GENFI).RESULTSThe new scale led to higher global severity scores than the CDR plus NACC FTLD: 1.4% of participants were now considered prodromal rather than asymptomatic, while 1.3% were now considered symptomatic rather than asymptomatic or prodromal. No participants with a clinical diagnosis of an FTD spectrum disorder were classified as asymptomatic using the new scales.DISCUSSIONAdding new domains to the CDR plus NACC FTLD leads to a scale that encompasses the wider phenotypic spectrum of FTD with further work needed to validate its use more widely.Highlights
The new Clinical Dementia Rating Dementia Staging Instrument plus National Alzheimer's Coordinating Center Behavior and Language Domains neuropsychiatric and motor (CDR plus NACC FTLD‐NM) rating scale was significantly positively correlated with the original CDR plus NACC FTLD and negatively correlated with the FTD Rating Scale (FRS).
No participants with a clinical diagnosis in the frontotemporal dementia spectrum were classified as asymptomatic with the new CDR plus NACC FTLD‐NM rating scale.
Individuals had higher global severity scores with the addition of the neuropsychiatric and motor domains.
A receiver operating characteristic analysis of symptomatic diagnosis showed nominally higher areas under the curve for the new scales.
The unique multidisciplinarity of diabetes‐related foot disease
Authors: van Netten Jaap J. , Apelqvist Jan , Bus Sicco A. , Fitridge Robert , Game Fran , Monteiro‐Soares Matilde , Senneville Eric , Schaper Nicolaas C. 
Published: April 2024

AbstractFew diseases globally require treatment from so many different disciplines as diabetes‐related foot disease. At least 25 different professionals may be involved: casting technicians, dermatologists, diabetes (educator) nurses, diabetologists, dieticians, endocrinologists, general practitioners, human movement scientists, infectious diseases experts, microbiologists, nuclear medicine physicians, orthopaedic surgeons, orthotists, pedorthists, physical therapists, plastic surgeons, podiatric surgeons, podiatrists, prosthetists, psychologists, radiologists, social workers, tissue viability physicians, vascular surgeons, and wound care nurses. A shared vocabulary and shared treatment goals and recommendations are then essential. The International Working Group on the Diabetic Foot (IWGDF) has produced guidelines and supporting documents to stimulate and support shared and multidisciplinary evidence‐based treatment in diabetes‐related foot disease. In this special virtual issue of Diabetes/Metabolism Research and Reviews, all 21 documents of the 2023 update of the IWGDF Guidelines are bundled, added with a further 6 reviews from multidisciplinary experts to drive future research and clinical innovations, based on their contributions to the International Symposium on the Diabetic Foot. We hope the readers will enjoy this special virtual issue, and widely implement the knowledge shared here in their daily clinical practice and research endeavours with the goal to improve the care for people with diabetes‐related foot disease.
Adaptive design trials in eating disorder research: A scoping review
Authors: Edney Laura C. , Pellizzer Mia L. 
Published: April 2024

AbstractObjectiveThis scoping review sought to map the breadth of literature on the use of adaptive design trials in eating disorder research.MethodA systematic literature search was conducted in Medline, Scopus, PsycInfo, Emcare, Econlit, CINAHL and ProQuest Dissertations and Theses. Articles were included if they reported on an intervention targeting any type of eating disorder (including anorexia nervosa, bulimia nervosa, binge‐eating disorder, and other specified feeding or eating disorders), and employed the use of an adaptive design trial to evaluate the intervention. Two independent reviewers screened citations for inclusion, and data abstraction was performed by one reviewer and verified by a second.ResultsWe identified five adaptive design trials targeting anorexia nervosa, bulimia nervosa and binge‐eating disorder conducted in the USA and Australia. All employed adaptive treatment arm switching based on early response to treatment and identified a priori stopping rules. None of the studies included value of information analysis to guide adaptive design decisions and none included lived experience perspectives.DiscussionThe limited use of adaptive designs in eating disorder trials represents a missed opportunity to improve enrolment targets, attrition rates, treatment outcomes and trial efficiency. We outline the range of adaptive methodologies, how they could be applied to eating disorder research, and the specific operational and statistical considerations relevant to adaptive design trials.Public significanceAdaptive design trials are increasingly employed as flexible, efficient alternatives to fixed trial designs, but they are not often used in eating disorder research. This first scoping review identified five adaptive design trials targeting anorexia nervosa, bulimia nervosa and binge‐eating disorder that employed treatment arm switching adaptive methodology. We make recommendations on the use of adaptive design trials for future eating disorder trials.
Habitat modifies the relationship between grass and herbivore species richness in a South African savanna
Authors: Čuda Jan , Pyšková Klára , Hejda Martin , Foxcroft Llewellyn C. , MacFadyen Sandra , Storch David , Tropek Robert , Zambatis Guin , Pyšek Petr 
Published: April 2024

AbstractThe savanna ecosystem is dominated by grasses, which are a key food source for many species of grazing animals. This relationship creates a diverse mosaic of habitats and contributes to the high grass species richness of savannas. However, how grazing interacts with environmental conditions in determining grass species richness and abundance in savannas is still insufficiently understood. In the Kruger National Park, South Africa, we recorded grass species and estimated their covers in 60 plots 50 × 50 m in size, accounting for varying proximity to water and different bedrocks. To achieve this, we located plots (i) near perennial rivers, near seasonal rivers, and on crests that are distant from all water sources and (ii) on nutrient‐rich basaltic and nutrient‐poor granitic bedrock. The presence and abundance of large herbivores were recorded by 60 camera traps located in the same plots. Grass cover was higher at crests and seasonal rivers than at perennial rivers and on basalts than on granites. The relationship between grass species richness and herbivore abundance or species richness was positive at crests, while that between grass species richness and herbivore species richness was negative at seasonal rivers. We found no support for controlling the dominance of grasses by herbivores in crests, but herbivore‐induced microsite heterogeneity may account for high grass species richness there. In contrast, the decrease in grass species richness with herbivore species richness at seasonal rivers indicates that the strong grazing pressure over‐rides the resistance of some species to grazing and trampling. We suggest that the relationships between grasses and herbivores may work in both directions, but the relationship is habitat‐dependent, so that in less productive environments, the effect of herbivores on vegetation prevails, while in more productive environments along rivers the effect of vegetation and water supply on herbivores is more important.
Climate and habitat type interact to influence contemporary dispersal potential in Prairie Smoke (Geum triflorum)
Authors: Sullivan Lauren L. , Portlas Zoe M. , Jaeger Kelsey M. , Hoffner Mercedes , Hamilton Jill A. 
Published: April 2024

AbstractUnderstanding dispersal potential, or the probability a species will move a given distance, under different environmental conditions is essential to predicting species' ability to move across the landscape and track shifting ecological niches. Two important drivers of dispersal ability are climatic differences and variations in local habitat type. Despite the likelihood these global drivers act simultaneously on plant populations, and thus dispersal potential is likely to change as a result, their combined effects on dispersal are rarely examined. To understand the effect of climate and varying habitat types on dispersal potential, we studiedGeum triflorum—a perennial grassland species that spans a wide range of environments, including both prairie and alvar habitats. We explored how the climate of the growing season and habitat type (prairie vs. alvar) interact to alter dispersal potential. We found a consistent interactive effect of climate and habitat type on dispersal potential. Across prairie populations, an increased number of growing degree days favored traits that increase dispersal potential or the probability of dispersing farther distances. However, for alvar populations, dispersal potential tended to decrease as the number of growing degree days increased. Our findings suggest that under continued warming, populations in prairie habitats will benefit from increased gene flow, while alvar populations will become increasingly segregated, with reduced potential to track shifting fitness optima.
Inspiring basic and applied research in genome integrity mechanisms: Dedication to Samuel H. Wilson
Authors: Yan Shan , Gaddameedhi Shobhan , Sobol Robert W. 
Published: April 2024

AbstractThis Special Issue (SI) of Environmental and Molecular Mutagenesis (EMM), entitled “Inspiring Basic and Applied Research in Genome Integrity Mechanisms,” is to update the community on recent findings and advances on genome integrity mechanisms with emphasis on their importance for basic and environmental health sciences. This SI includes two research articles, one brief research communication, and four reviews that highlight cutting edge research findings and perspectives, from both established leaders and junior trainees, on DNA repair mechanisms. In particular, the authors provided an updated understanding on several distinct enzymes (e.g., DNA polymerase beta, DNA polymerase theta, DNA glycosylase NEIL2) and the associated molecular mechanisms in base excision repair, nucleotide excision repair, and microhomology‐mediated end joining of double‐strand breaks. In addition, genome‐wide sequencing analysis or site‐specific mutational signature analysis of DNA lesions from environmental mutagens (e.g., UV light and aflatoxin) provide further characterization and sequence context impact of DNA damage and mutations. This SI is dedicated to the legacy of Dr. Samuel H. Wilson from the U.S. National Institute of Environmental Health Sciences at the National Institutes of Health.
Bayesian detection with feedback for cooperative spectrum sensing in cognitive UAV networks
Authors: Wu Jun , Su Mingkun , Qiao Lei , Cao Weiwei 
Published: April 2024

AbstractUnmanned aerial vehicles (UAVs) are becoming a popular research topic in applications that do not require human intervention. A variety of applications and devices coexist in the environment where UAVs operate, resulting in a serious spectrum shortage. Therefore, cognitive radio (CR) is a promising solution for opportunistic access to underutilized spectrum bands by the primary user (PU) through cooperative spectrum sensing (CSS) technique. However, the flexible location of UAVs makes CSS inefficient and even difficult to be implemented. In view of this, a cognitive UAV network model consisting of a pair of UAVs which follows a circular flight trajectory to participate in CSS is proposed in a spectrum sensing frame structure. According to the local energy detection, we further propose an optimization problem about the stopping time in a quickest detection paradigm and conduct out Bayesian detection method with feedback to minimize the sensing delay and the false alarm probability by optimizing the stopping time. Moreover, we theoretically derive the optimal threshold pair and prove the optimal stopping time by means of Markov process. At last, a series of numerical simulations are shown to corroborate the proposed Bayesian detection method with feedback, in terms of the false alarm probability, the sensing delay, and achievable throughput. In contrast to the classic Neyman‐Pearson and Bayesian detection methods, the advantage of Bayesian detection method with feedback sensing is presented.