bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Thousand-Pulsar-Array programme on MeerKAT – XIII. Timing, flux density, rotation measure, and dispersion measure time series of 597 pulsars
Authors: Keith M J , Johnston S , Karastergiou A , Weltevrede P , Lower M E , Basu A , Posselt B , Oswald L S , Parthasarathy A , Cameron A D , Serylak M , Buchner S 
Published: April 2024

ABSTRACT
We report here on the timing of 597 pulsars over the last four years with the MeerKAT telescope. We provide times of arrival, pulsar ephemeris files, and per-epoch measurements of the flux density, dispersion measure (DM), and rotation measure (RM) for each pulsar. In addition, we use a Gaussian process to model the timing residuals to measure the spin frequency derivative at each epoch. We also report the detection of 11 glitches in nine individual pulsars. We find significant DM and RM variations in 87 and 76 pulsars, respectively. We find that the DM variations scale approximately linearly with DM, which is broadly in agreement with models of the ionized interstellar medium. The observed RM variations seem largely independent of DM, which may suggest that the RM variations are dominated by variations in the interstellar magnetic field on the line of sight, rather than varying electron density. We also find that normal pulsars have around 5 times greater amplitude of DM variability compared to millisecond pulsars, and surmise that this is due to the known difference in their velocity distributions.
[11C]-methionine positron emission tomography in the evaluation of pediatric low-grade gliomas
Authors: Kim Emily Y , Vavere Amy L , Snyder Scott E , Chiang Jason , Li Yimei , Patni Tushar , Qaddoumi Ibrahim , Merchant Thomas E , Robinson Giles W , Holtrop Joseph L , Shulkin Barry L , Bag Asim K 
Published: April 2024

Abstract

Background
[11C]-Methionine positron emission tomography (PET; [11C]-MET-PET) is principally used for the evaluation of brain tumors in adults. Although amino acid PET tracers are more commonly used in the evaluation of pediatric brain tumors, data on [11C]-MET-PET imaging of pediatric low-grade gliomas (pLGG) is scarce. This study aimed to investigate the roles of [11C]-MET-PET in the evaluation of pLGGs.

Methods
Eighteen patients with newly diagnosed pLGG and 26 previously treated pLGG patients underwent [11C]-MET-PET met the inclusion and exclusion criteria. Tumor-to-brain uptake ratio (TBR) and metabolic tumor volumes were assessed for diagnostic performances (newly diagnosed, 15; previously treated 26), change with therapy (newly diagnosed, 9; previously treated 7), and variability among different histology (n = 12) and molecular markers (n = 7) of pLGGs.

Results
The sensitivity of [11C]-MET-PET for diagnosing pLGG, newly diagnosed, and previously treated combined was 93% for both TBRmax and TBRpeak, 76% for TBRmean, and 95% for qualitative evaluation. TBRmax showed a statistically significant reduction after treatment, while other PET parameters showed a tendency to decrease. Median TBRmax, TBRpeak, and TBRmean values were slightly higher in the BRAFV600E mutated tumors compared to the BRAF fused tumors. Median TBRmax, and TBRpeak in diffuse astrocytomas were higher compared to pilocytic astrocytomas, but median TBRmean, was slightly higher in pilocytic astrocytomas. However, formal statistical analysis was not done due to the small sample size.

Conclusions
Our study shows that [11C]-MET-PET reliably characterizes new and previously treated pLGGs. Our study also shows that quantitative parameters tend to decrease with treatment, and differences may exist between various pLGG types.
Combining anodic alcohol oxidative coupling for C–C bond formation with cathodic ammonia production
Authors: Xu Leitao , Chen Wei , Wang Cairong , Wu Wenjie , Yao Yelin , Huang Zhifeng , Wu Jingcheng , Yang Ming , Wu Yandong , Xie Dianke , Zou Yuqin , Wang Shuangyin 
Published: April 2024

ABSTRACT
Electrocatalytic oxidation of alcohols using heterogeneous catalysts is a promising aqueous, energy-efficient and environmentally friendly approach, especially for coupling different alcohols to prolong the carbon chain via co-oxidation. Precisely regulating critical steps to tailor electrode materials and electrolyte composition is key to selectively coupling alcohols for targeted synthesis. However, selectively coupling different alcohols remains challenging due to the lack of effective catalyst and electrolyte design promoting specific pathways. Herein, we demonstrate a paired electrolysis strategy for combining anodic oxidative coupling of ethanol (EtOH) and benzyl alcohol (PhCH2OH) to synthesize cinnamaldehyde (CAL) and cathodic ammonia production. The strategies involve: (i) utilizing the salt-out effect to balance selective oxidation and coupling rates; (ii) developing platinum-loaded nickel hydroxide electrocatalysts to accelerate intermediate coupling kinetics; (iii) introducing thermodynamically favorable nitrate reduction at the cathode to improve coupling selectivity by avoiding hydrogenation of products while generating valuable ammonia instead of hydrogen. We achieved 85% coupling selectivity and 278 μmol/h NH3 productive rate at 100 mA/cm2 with a low energy input (∼1.63 V). The membrane-free, low energy, scalable approach with a wide substrate scope highlights promising applications of this methodology. This work advances heterogeneous electrocatalytic synthesis through rational design principles that integrate anodic oxidative coupling with cathodic nitrate reduction reactions, having synergistic effects on efficiency and selectivity.
Minimizing the ratio of ionizable lipid in lipid nanoparticles for in vivo base editing
Authors: Chen Qiubing , Wang Xuebin , Zhang Yizhou , Tian Ming , Duan Junyi , Zhang Ying , Yin Hao 
Published: April 2024

ABSTRACT
Lipid nanoparticles (LNPs) have gained clinical approval as carriers for both siRNA and mRNA. Among the crucial components of LNPs, ionizable lipids play a pivotal role in determining the efficiency of RNA delivery. In this study, we synthesized a series of ionizable lipids, denoted as HTO, with a higher count of hydroxyl groups compared to SM-102. Remarkably, LNPs based on HTO12 lipid demonstrated comparable mRNA delivery efficiency and biosafety to those based on SM-102. However, the former reduced the ratio of ionizable lipid/total lipids to mRNA in LNPs by 2.5 times compared to SM-102. The HTO12 LNP efficiently encapsulated adenine base editor mRNA and sgRNA targeting Pcsk9, leading to substantial gene editing within the liver of mice and effective reduction of the target protein. Our study underscores that ionizable lipids with multiple hydroxyl groups may facilitate an improved lipid-to-mRNA ratio to minimize the dosage of ionizable lipids for in vivo delivery.
Arc Foundations and Subduction Initiation: Insights into the Magmatic Evolution of the Lower Crust/Upper Mantle of the Izu–Bonin Forearc during Subduction Initiation
Authors: Loocke Matthew P , Snow Jonathan E 
Published: April 2024

Abstract
Our understanding of the processes at work in the lower crust/upper mantle transition zone during subduction initiation and early arc development has suffered from a general lack of in situ samples. Here, we present the results of petrographic and geochemical analysis of 34 samples (9 harzburgites, 13 dunites, 2 orthopyroxenites, 3 olivine-gabbros, and 7 wehrlites) collected from the inner trench wall of the Bonin Ridge, Izu–Bonin forearc. The sample suite records three main melt–rock reaction events involving melts with forearc basalt (FAB)-like, boninitic, and transitional compositions. The wehrlitic and gabbroic rocks trend towards more transitional to FAB compositions and the rest towards more boninitic compositions. The crosscutting occurrence of all three events in a single sample (wehrlite D31–106) establishes a relative timing of the events like that reported for the volcanic edifice of the Bonin Ridge, which transitioned from forearc basalt volcanism at subduction initiation (c.a., 51–52 Ma) to boninitic volcanism (c.a., 50–51 Ma) as the subduction system matured. We therefore suggest that the lower crust/upper mantle transition of the Bonin Ridge preserves a record of the transition from FAB melts created by decompression melting at subduction initiation to arc-type flux melting and boninitic volcanism thereafter. Orthopyroxenites and two anomalously fresh harzburgites from the sample suite are suggested to represent the later boninitic melts and possibly the result of hybridization between such melts and residual peridotites, respectively. Diffuse melt–rock reaction between the later boninites and/or subduction-related fluids and the earlier-formed FAB-related crust is recorded by enrichments in fluid mobile elements and depletions in first row transition metals in clinopyroxenes from a metasomatic vein in wehrlite sample D31–106. The chemistry of the wehrlitic and gabbroic clinopyroxenes suggests that they crystallized from hydrous, highly depleted melts which lack a slab fluid signature. We thus suggest that highly depleted melt fractions might be created early on during subduction initiation by the introduction of seawater into the proto-mantle wedge. The overall FAB-like nature of the crustal wehrlites and gabbros would suggest that most of the lower arc crust was created by forearc extension during/following subduction initiation and that later, mature arc volcanism may have contributed little or no material to the lower crust/upper mantle record in the outer forearc.
Advances in the study of microparticles in diabetic retinopathy
Authors: Hou Yifeng , Tang Yun , Cai Shanjun 
Published: April 2024

Abstract
Diabetic retinopathy (DR) is one of the common diabetic microangiopathies, which severely impairs vision in diabetic population. The underlying mechanisms regarding the development of DR are not fully understood, and there is a lack of biomarkers to guide clinical, assessment of disease progression. Recently researchers have found that microparticles (MP) and its bioactive molecules are involved in the development of DR. MP is widely distributed in the circulation and can exert autocrine and paracrine benefits in intercellular signalling, provide a catalytic platform for the thrombospondin complex to promote coagulation, and promote the accumulation of reactive oxygen species to cause endothelial damage. MP interacts with advanced glycosylation end products (AGE) and AGE receptor (RAGE) to activate inflammatory pathways. MP carries a variety of miRNAs that regulate the vascular endothelial growth factor generation pathway. MP has also been applied to the exploration of mesenchymal stromal cell replacement therapy to treat DR. In a word, MP provides new ideas for the study of DR. MP has emerged as a marker to assess the progression of DR. As a potential therapeutic target, MP also has considerable research value.
The Excess-Path-Length Distribution of Electrons in Electromagnetic Cascade Showers
Authors: Nakatsuka Takao , Okei Kazuhide 
Published: April 2024

Abstract
The excess-path-length distribution of cascade-shower particles due to the multiple Coulomb scattering of shower electrons is investigated analytically. A diffusion equation for the distribution under the Landau approximation is proposed and solved under the conditions of neglecting and including the ionization loss. Contributions of the Rutherford single scattering on the distribution are also investigated and found to dominate in very large excess regions of path length. The excess-path-length distribution of shower electrons is observed as an arrival-time distribution at a given thickness of traverse. The present results will be valuable for qualitative and quantitative analyses of cascade showers observed by the arrival-time distribution.
Appealing to Americans’ altruism is not enough to nudge them to accept novel vaccines
Authors: Drabo Emmanuel F , Kelley Marcella A , Gong Cynthia L 
Published: April 2024

Abstract

Background
The role of altruism in the acceptance of novel preventive healthcare technologies like vaccines has not been thoroughly elucidated.

Methods
We 1:1 randomized n = 2004 Amazon Mechanical Turk (MTurk) participants residing in the USA into a control or treatment arm with vaccination decisions framed altruistically, to elicit their preferences for COVID-19 vaccination using web-based discrete choice experiments. We used conditional and mixed logit models to estimate the impact of framing decisions in terms of altruism on vaccination acceptance.

Results
Valid responses were provided by 1674 participants (control, n = 848; treatment, n = 826). Framing vaccination decisions altruistically had no significant effect on vaccination acceptance. Further, respondents’ degree of altruism had no association with vaccination acceptance.

Limitations
The MTurk sample may not be representative of the American population. We were unable to ascertain concordance between stated and revealed preferences.

Conclusions and Implications
Framing vaccination decisions in terms of altruism does not appear to significantly influence vaccination acceptance and may not be an effective nudging mechanism to increase the uptake of novel vaccines. Instead, a favorable vaccination profile appears to be the primary driver of uptake.
Same-Day Versus Staged Spinal Fusion: A Meta-analysis of Clinical Outcomes
Authors: Daher Mohammad , Nassar Joseph E. , Balmaceno-Criss Mariah , Diebo Bassel G. , Daniels Alan H. 
Published: April 2024

Study Design.
Meta-analysis.

Objective.
This meta-analysis aims to compare same-day versus staged spine surgery, assessing their effects on patient care and health care system efficiency.

Background.
In spinal surgery, the debate between whether same-day and staged surgeries are better for patients continues, as the decision may impact patient-related outcomes, health care resources, and overall costs. While some surgeons advocate for staged surgeries, citing reduced risks of complications, others proclaim same-day surgeries may minimize costs and length of hospital stays.

Methods.
PubMed, Cochrane, and Google Scholar (pages 1–20) were searched up until February 2024. The studied outcomes were operative room (OR) time, estimated blood loss (EBL), length of hospital stay (LOS), overall complications, venous thromboembolism (VTE), death, operations, and nonhome discharge.

Results.
Sixteen retrospective studies were included in this meta-analysis, representing a total of 2346 patients, of which 644 underwent staged spinal fusion surgeries and 1702 same-day surgeries. No statistically significant difference was observed in EBL between staged and same-day surgery groups. However, the staged group exhibited a statistically significant longer OR time (P=0.05) and LOS (P=0.004). A higher rate of overall complications (P=0.002) and VTE (P=0.0008) was significantly associated with the staged group. No significant differences were found in the rates of death, reoperations, and nonhome discharge between the 2 groups.

Conclusions.
Both staged and same-day spinal fusion surgeries showed comparable rates of death, operations, and nonhome discharges for patients undergoing spinal surgeries. However, given the increased OR time, LOS, and complications associated with staged spinal surgeries, this study supports same-day surgeries when possible to minimize the burden on healthcare resources and enhance efficiency.
Corneal Transplantation in a Patient With Nonperforating Ocular Contusion Caused by a High-Pressure Washer: A Case Report
Authors: Miyata Mana , Ono Takashi , Mori Yosai , Sakisaka Toshihiro , Nejima Ryohei , Iwasaki Takuya , Miyai Takashi , Miyata Kazunori 
Published: April 2024

Purpose:
This report details a rare case of a high-pressure washer injury that caused ocular contusion, vitreous hemorrhage, and irreversible corneal edema without perforation necessitating corneal transplantation.

Methods:
The medical chart of a patient with a high-pressure washer injury at Miyata Eye Hospital (Miyazaki, Japan) was retrospectively reviewed.

Results:
A 57-year-old man presented to our hospital with a contusion in the left eye caused by a high-pressure washer 1 day prior to the visit. The visual acuity in the left eye was hand motion. Slit-lamp examination of the left eye revealed the presence of corneal epithelial defects, conjunctival lacerations, hyphema, and lacerated iris. Mild clouding of the lens was observed in the anterior chambers, suggestive of cataract. Anterior segment optical coherence tomography revealed the presence of blood in the anterior chamber and a thickened and edematous cornea. Ultrasound examination revealed the presence of vitreous hemorrhage. Therefore, vitreous surgery and traumatic cataract removal were performed under general anesthesia. Postoperatively, the corneal edema and marked opacity persisted, accompanied by glaucoma, and the visual acuity was measured at 0.01. Penetrating keratoplasty was performed 1 year and 2 months after the injury, and scleral fixation of the intraocular lens was performed under local anesthesia 2 years after the injury. The final visual acuity was 0.1 under rigid gas-permeable contact lens usage 3.5 years after sustaining the injury, and the patient required anti-glaucoma drugs.

Conclusions:
Our patient presented with ocular trauma caused by a high-pressure washer. Corneal transplantation was required although no ocular lacerations were detected. Sufficient instructions must be provided on the usage of heavy machinery to develop a safe working environment.
Embryology with precision: effective quality control in the in vitro fertilization laboratory
Authors: Basar Murat , Unsal Evrim , Ergun Yagmur 
Published: April 2024

The purpose of this review is to address the critical need for standardization and clarity in the use of key performance indicators (KPIs) within the realm of in vitro fertilization (IVF), particularly emphasizing the integration of preimplantation genetic testing (PGT) processes. This review is timely and relevant given the persistently modest success rates of IVF treatments, which stand at approximately 30%, and the growing complexity of IVF procedures, including PGT practices. The review synthesizes recent findings across studies focusing on technical and clinical KPIs in embryology and genetic laboratories, identifying gaps in current research and practice, particularly the lack of standardized KPIs and terminology.Recent findings highlighted include the critical evaluation of technical KPIs such as Intracytoplasmic Sperm Injection (ICSI) fertilization rates, embryo development rates, and laboratory performance metrics, alongside clinical KPIs like the proportion of mature oocytes and clinical pregnancy rates. Notably, the review uncovers a significant gap in integrating and standardizing KPIs for PGT applications, which is essential for improving IVF outcomes and genetic diagnostic accuracy.The implications of these findings are profound for both clinical practice and research. For clinical practice, establishing a standardized set of KPIs, especially for PGT, could significantly enhance the success rates of IVF treatments by providing clearer benchmarks for quality and performance. For research, this review underscores the necessity for further studies to close the identified gaps, promoting a more integrated and standardized approach to KPIs in IVF and PGT processes. This comprehensive approach will not only aid in improving clinical outcomes but also in advancing the field of reproductive medicine.
Missed Opportunities in Screening for Glaucoma
Authors: Tuulonen Anja , Leinonen Sanna , Jóhannesson Gauti 
Published: April 2024

Purpose:
To create a holistic and realistic view regarding current knowledge, understanding, and challenges of screening in general and in glaucoma.

Methods/Results:
Based upon available literature, all systems suffer from the same challenges: huge variability of care practices (despite guidelines), simultaneous under care and over care, as well as the unsustainable increase of costs. While the magnitude of these challenges differs immoderately between well-off and developing countries, the Western world has already demonstrated that simply doing more than what we currently do is not the solution. System outcomes also matter in screening, that is, its benefits should outweigh any harms (over-care, false positives/negatives, uncertain findings, etc.) and be cost-effective. However, even when the evidence does not support screening (as is currently the case in glaucoma), it may feel justified as “at least we are doing something.” Strong commercial interests, lobbying and politics star as well and will influence the control arm even in high-quality randomized screening trials (RCT).

Conclusions:
As resources will never be sufficient for all health care activities that providers wish to deliver and what people wish to receive, we need to ask big questions and adopt a public health perspective in glaucoma and eye care. How can we create and maintain a sustainable balance between finding and treating underserved high-risk patients without burdening the broader patient population and societies with over-diagnostics and treatments? Considering numerous biases related to screening, including the variability in care practices, a high-quality RCT for the screening of glaucoma would be very challenging to organize and evaluate its universal usefulness.
The Impact of an Online Educational Intervention on Attitudes of Primary Care Clinicians Toward Managing Patients With Substance Use Disorders
Authors: PhengPhal Miadette , Knight Margaret 
Published: April 2024

AbstractBackgroundNegative attitudes of primary care clinicians toward patients with substance use disorders affect the quality and delivery of care in this highly marginalized patient population.PurposeThis project aimed to improve negative attitudes of primary care clinicians toward managing patients with substance use disorders.MethodsA pretest-and-posttest design, employing multidimensional online educational interventions, was implemented from June to August 2020. The participants (n= 18) were recruited from a pool of 70 primary care clinicians at two community primary care agencies. The Affect Scale for Substance Users and 15-item Opening Minds Scale for Health Care Providers were administered before, immediately after, and 30 days after the intervention.ResultsThere were statistically significant reductions in the immediate postintervention and 30-day postintervention mean scores in the Affect Scale for Substance Users and the disclosure and help-seeking subscale when compared with those of preintervention. The change in attitudes was maintained at 30-day postintervention.ConclusionsThe project findings support conducting and evaluating future educational programs for substance use disorder management among primary care clinicians. Because of the heterogeneity of the participants and the small sample size, the project results have limited generalizability. Overall, this project is among one of the few aimed at substance use disorder management among primary care clinicians.