bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROFOUND INVESTIGATION OF DUST CHEMICAL COMPONENT IN INDUSTRIAL EMISSIONS FOR CORRECT ESTIMATION OF GEOECOLOGICAL IMPACT AND MONITORING
Authors: May Irina V. , Zagorodnov Sergey Yu. 
Published: March 2024

Background. Effective management of dust emissions from industrial enterprises should be based on reliable data on emission sources and emitted components. Correct estimation of geoecological impacts exerted by dust emissions is a complicated process due to chemical diversity of the soil component in them.
Aim. The aim was to test a practical approach to identifying actual ambient air pollution with solid particles in a zone influenced by an economic entity for correct estimation of impacts and monitoring of ambient air quality.
Materials and methods. Samples of industrial dust emissions were analyzed with a scanning electronic high-resolution microscope (magnification was from x5 to x300,000; acceleration voltage varied between 0.3 to 30 kW) with S3400N HITACHI x-ray fluorescent device (the limit of detection was approximately 5–10 mass % and the minimum field of view was 100 µm). X-ray photographs were processed by using XRD 6000/7000 software, Version 5.21. The results obtained by calculating dispersion of the dust component were mapped with ArcView 3.2 and ArcGIS 9.3.1., GIS-platforms created by ESRI.
Results. Complex investigations of dust emissions were performed at a selected enterprise and this made it possible to identify a profile of the dust component in emissions from major sources. Actual composition of dusts emitted by the analyzed enterprise was established to differ fundamentally from the data declared in the inventory lists of emissions issued by the enterprise. The results of dispersion calculations gave grounds for spotting out substances that were priority (marker) ones for the analyzed production and we also estimated actual effects produced by dust emissions on ambient air.
Conclusions. The study results allow concluding that a dust emission profile is a reliable instrument for estimating actual impacts of an industrial enterprise on ambient air. It can be applied to solve tasks within setting standards, monitoring and estimating actual impacts exerted by anthropogenic dust emissions when environmental measures are being planned and developed.
PROFESSIONAL WELL-BEING AND RESILIENCE OF DOCTORS AND MEDICAL STAFF
Authors: Shmeleva Elena A. , Kislyakov Pavel A. , Karaseva Tatiana V. , Silaeva Olga A. , Prijatkin Danila A. 
Published: March 2024

Background. The well-being of doctors and medical staff is vital to their professional activities. Resilience is recognized as a key condition for well-being and is an important factor in socionomic professions. In medical practice, resilience helps doctors and medical staff cope with difficulties and overcome burnout.
Purpose. The aim is to study the relationship of well-being in the professional activities of doctors and medical personnel with resilience and conditions supporting it.
Methods. A group of 178 medical workers, including doctors, secondary and junior medical personnel, was studied. The resilience scale provided a general indicator of resilience and its components, the WHO well-being scale assessed well-being over the past two weeks. The attractiveness of the profession, the mood it evokes and the satisfaction of the individual with the need for security were evaluated. The relationships between the variables were studied using Spearman correlation coefficients, taking into account the position and multiple regression analysis.
Results. Significant positive correlations were found between well-being and general resilience (r = 0,599, p < 0,01), position (r = 0,361, p < 0,01), attractiveness of the profession (r = 0,359, p < 0,01), mood (r = 0,361, p < 0,01) and satisfaction with the need for security (r = 0,159, p < 0,05).
Conclusion. Well-being in the professional sphere of doctors and medical personnel is associated with commitment to professional activity, control and risk-taking, attractiveness of the profession, the mood that it causes, satisfaction of the need for psychological security. The results obtained confirm the consideration of resilience as a resource component of the professional well-being of doctors and medical personnel. Strategies for ensuring well-being in the profession should take into account the practices of interventions that stimulate the identified correlates.
Use of amniotic membrane in hard-to-heal wounds: a multicentre retrospective study
Authors: Ditmars Frederick S , Kay Kristen E , Broderick T Christopher , Fagg W Samuel 
Published: March 2024

Objective: Hard-to-heal (chronic) wounds negatively impact patients and are a source of significant strain on the healthcare system and economy. These wounds are often resistant to standard of care (SoC) wound healing approaches due to a diversity of underlying pathologies. Cellular, acellular, and matrix-like products, such as amniotic membranes (AM), are a potential solution to these challenges. A growing body of evidence suggests that AM may be useful for treatment-resistant wounds; however, limited information is available regarding the efficacy of dehydrated amniotic membrane (DHAM) on multi-aetiology, hard-to-heal wounds. Therefore, we analysed the efficacy of DHAM treatment in reducing the size of hard-to-heal diabetic and venous leg ulcers (VLUs) that had failed to improve after SoC-based treatments. Method: In this multicentre retrospective study, we analysed wound size during clinic visits for patients being treated for either diabetic or VLUs. During each visit, the treatment consisted of debridement followed by application of DHAM. Each wound was measured after debridement and prior to DHAM application, and wound volumes over time or number of DHAM applications were compared. Results: A total of 18 wounds in 11 patients were analysed as part of this study. Wounds showed a significant reduction in volume after a single DHAM application, and a 50% reduction in wound size was observed after approximately two DHAM applications. These findings are consistent with reports investigating DHAM treatment of diabetic ulcers that were not necessarily resistant to treatment. Conclusion: To our knowledge, this study is the first to directly compare the efficacy of standalone DHAM application to hard-to-heal diabetic and venous leg ulcers, and our findings indicate that DHAM is an effective intervention for resolving these types of wounds. This suggests that implementing this approach could lead to fewer clinic visits, cost savings and improved patient quality of life. Declaration of interest: This research was supported in part by Merakris Therapeutics, US, and facilitated access to deidentified patient datasets, which may represent a perceived conflict of interest; however, the primary data analysis was performed by FSB who is unaffiliated with Merakris Therapeutics. TCB is a founder, employee of and shareholder in Merakris Therapeutics; WSF is a co-founder of, consultant for, and shareholder in Merakris Therapeutics, and was also supported by the National Institutes of Health National Center for Advancing Translational Sciences Clinical and Translational Science Awards Grant KL2 Scholars Program (KL2TR001441). The research was also supported through endowments to WSF from the University of Texas Medical Branch Mimmie and Hallie Smith Endowed Chair of Transplant Research and the John L Hern University Chair in Transplant Surgery.
Data encryption with chaotic light in the long wavelength infrared atmospheric window
Authors: Didier Pierre , Zaminga Sara , Spitz Olivier , Wu Jiagui , Awwad Elie , Maisons Gregory , Grillot Frederic 
Published: March 2024

In environments where traditional fiber optic cables are impractical, free-space optical communications offer a promising solution for transmitting large amounts of data, especially in the mid-infrared wavelength range. Despite the advantages of minimal atmospheric interference and stable signals, the vulnerability of wireless optical communications to eavesdropping poses a significant challenge. This study addresses this challenge by demonstrating a method for privately transmitting optical data using photonic chaos from distributed feedback quantum cascade lasers operating at 9.3 µm. Signal processing techniques are applied to enhance the quality of the transmission over distances exceeding 30 m, accompanied by a comprehensive analysis of the photonic chaos complexity to ensure data confidentiality. These findings mark a significant advancement in developing private communications systems within the thermal atmospheric window, with a substantially reduced risk of interception by adversaries. The research not only contributes to secure communications but also has potential implications for enhancing security of data transmission in challenging environments, impacting various industries and applications.
Long-read sequencing for fast and robust identification of correct genome-edited alleles: PCR-based and Cas9 capture methods
Authors: McCabe Christopher V. , Price Peter D. , Codner Gemma F. , Allan Alasdair J. , Caulder Adam , Christou Skevoulla , Loeffler Jorik , Mackenzie Matthew , Malzer Elke , Mianné Joffrey , Nowicki Krystian J. , O’Neill Edward J. , Pike Fran J. , Hutchison Marie , Petit-Demoulière Benoit , Stewart Michelle E. , Gates Hilary , Wells Sara , Sanderson Nicholas D. , Teboul Lydia 
Published: March 2024

Background
Recent developments in CRISPR/Cas9 genome-editing tools have facilitated the introduction of precise alleles, including genetic intervals spanning several kilobases, directly into the embryo. However, the introduction of donor templates, via homology directed repair, can be erroneous or incomplete and these techniques often produce mosaic founder animals. Thus, newly generated alleles must be verified at the sequence level across the targeted locus. Screening for the presence of the desired mutant allele using traditional sequencing methods can be challenging due to the size of the interval to be sequenced, together with the mosaic nature of founders.

Methodology/Principal findings
In order to help disentangle the genetic complexity of these animals, we tested the application of Oxford Nanopore Technologies long-read sequencing at the targeted locus and found that the achievable depth of sequencing is sufficient to offset the sequencing error rate associated with the technology used to validate targeted regions of interest. We have assembled an analysis workflow that facilitates interrogating the entire length of a targeted segment in a single read, to confirm that the intended mutant sequence is present in both heterozygous animals and mosaic founders. We used this workflow to compare the output of PCR-based and Cas9 capture-based targeted sequencing for validation of edited alleles.

Conclusion
Targeted long-read sequencing supports in-depth characterisation of all experimental models that aim to produce knock-in or conditional alleles, including those that contain a mix of genome-edited alleles. PCR- or Cas9 capture-based modalities bring different advantages to the analysis.
Barriers to implementing patient safety incident reporting and learning guidelines in specialised care units, KwaZulu-Natal: A qualitative study
Authors: Gqaleni T. M. H. , Mkhize Sipho W. 
Published: March 2024

Background
Globally, increased occurrences of patient safety incidents have become a public concern. The implementation of Patient safety incidents reporting and learning guidelines is fundamental to reducing preventable patient harm. To improve the implementation of these guidelines in specialised care units in KwaZulu-Natal, the views of healthcare professionals were unearthed.

Aim
This study explores the healthcare professionals’ views toward the implementation of Patient safety incident reporting and learning guidelines in specialised care units.

Methods
A descriptive, explorative qualitative approach was used to collect qualitative data from healthcare professionals working in specialised care units. The study was conducted in specialised care units of three purposely selected public hospitals in two districts of KwaZulu-Natal. Group discussions and semi-structured interviews were conducted from August to October 2021. Content data analysis was performed using Tesch’s method of analysis process.

Results
The main themes that emerged during data analysis were; ineffective reporting system affecting the communication of Patient safety incident guidelines, inadequate institutional and management support for the healthcare professionals, insufficient education and training of healthcare professionals, and poor human resources affecting the implementation of Patient Safety Incident guidelines. The findings highlighted that there were more major barriers to the implementation of the Patient safety incident reporting and learning guidelines.

Conclusion
This study confirmed that the Patient safety incident reporting and learning guidelines are still not successfully implemented in the specialised care units and the barriers to implementation were highlighted. For rigorous implementation in South Africa, the study recommends revised Patient safety incident reporting and learning guidelines, designed in consultation with the frontline healthcare professionals. These must consist of standardised, simple- user-friendly reporting process as well as a better implementation strategy to guide the healthcare professionals. Continuous professional development programmes may play an important role in the facilitation of the implementation process.
Parental decision making about safer sleep practices: A qualitative study of the perspectives of families with additional health and social care needs
Authors: Barrett Simon , Barlow Jane , Cann Hannah , Pease Anna , Shiells Kate , Woodman Jenny , McGovern Ruth 
Published: March 2024

Introduction
Despite a decline in Sudden Unexpected Death in Infancy in the UK since 2004, inequalities have widened with higher rates among families from deprived backgrounds and those known to child protection services. Almost all cases involve parents who had engaged in unsafe sleeping practices despite awareness of safer sleeping advice.

Objective
To understand the perspectives surrounding safer sleep of families supported by statutory child protection agencies, and use behavior change theory to inform how approaches to providing safer sleep advice to these families may be modified.

Participants and setting
We interviewed 14 mothers, 2 fathers and one grandmother, who had recent contact with child protection services in northeast England.

Methods
In-depth, semi-structured interviews, with purposive sampling. The COM-B model (Capability, Opportunity, and Motivation) structured our analysis.

Results
Parents described how anxiety, sleep deprivation, settling infants, illness, and a desire to bond with infants influence their decision making about sleep. Parents valued credible, trusted sources and understanding how safer sleep practices protect infants. Responses to questions about ‘out of routine’ situations suggested social pressures surrounding routines and ‘good parenting’ may preclude parents from acknowledging risks and planning for these situations.

Conclusion
Open conversations tailored to the needs of families, focused upon understanding why and when parent(s) do or do not follow safer sleep guidance seem a promising way of promoting safer sleep practices. Safer sleep discussions with these families are likely to be best delivered as part of wider infant care by professionals who have an established and continuing trusting relationship with parents. While advice and information should be provided by any professional in contact with the family with the necessary expertise, sensitive conversations around sleeping practices, particularly co-sleeping, may be more easily facilitated by professionals where the statutory responsibility for safeguarding is less apparent.
The primary ciliary dyskinesia-related genetic risk score is associated with susceptibility to adult-onset asthma
Authors: Shigemasa Rie , Masuko Hironori , Oshima Hisayuki , Hyodo Kentaro , Kitazawa Haruna , Kanazawa Jun , Yatagai Yohei , Iijima Hiroaki , Naito Takashi , Saito Takefumi , Konno Satoshi , Hirota Tomomitsu , Tamari Mayumi , Sakamoto Tohru , Hizawa Nobuyuki 
Published: March 2024

Background
Disturbance of mucociliary clearance is an important factor in the pathogenesis of asthma. We hypothesized that common variants in genes responsible for ciliary function may contribute to the development of asthma with certain phenotypes.

Methods
Three independent adult Japanese populations (including a total of 1,158 patients with asthma and 2,203 non-asthmatic healthy participants) were studied. First, based on the ClinVar database (https://www.ncbi.nlm.nih.gov/clinvar/), we selected 12 common single-nucleotide polymorphisms (SNPs) with molecular consequences (missense, nonsense, and 3’-untranslated region mutation) in 5 primary ciliary dyskinesia (PCD)-related genes and calculated a PCD-genetic risk score (GRS) as a cumulative effect of these PCD-related genes. Second, we performed a two-step cluster analysis using 3 variables, including PCD-GRS, forced expiratory volume in 1 second (%predicted FEV1), and age of asthma onset.

Results
Compared to adult asthma clusters with an average PCD-GRS, clusters with high and low PCD-GRS had similar overall characteristics: adult-onset, female predominance, preserved lung function, and fewer features of type 2 immunity as determined by IgE reactivity and blood eosinophil counts. The allele frequency of rs1530496, a SNP representing an expression quantitative trait locus (eQTL) of DNAH5 in the lung, showed the largest statistically significant difference between the PCD-GRS-High and PCD-GRS-Low asthma clusters (p = 1.4 x 10−15).

Conclusion
Genes associated with PCD, particularly the common SNPs associated with abnormal expression of DNAH5, may have a certain influence on the development of adult-onset asthma, perhaps through impaired mucociliary clearance.
Trends in mental health problems among Swedish adolescents: Do school-related factors play a role?
Authors: Buli Benti Geleta , Larm Peter , Nilsson Kent W. , Hellström-Olsson Charlotta , Giannotta Fabrizia 
Published: March 2024

Aim
The aim of this study is to investigate the extent to which school-related factors, such as school liking, participation in decision-making, school-related parental support, teachers’ support, and school physical environment, explain trends in mental health problems. The problems considered are psychosomatic symptoms (PSS), depressive symptoms (DS), suicidal ideations (SI), and suicide attempts (SA) among Swedish adolescents of varying socioeconomic status (SES) from 2004 to 2020.

Methods
We analyzed data collected through repeated cross-sectional surveys from 19,873 15-year-old students at schools in a county in Sweden. Boys and girls each constituted 50% of the participants. We fitted linear and logistic regression models to investigate associations between the school-related factors and trends in mental health problems.

Results
Increased school-related parental support and school liking were cross-sectionally associated with decreased PSS, DS and SI, with school liking also associated with decreased SA. Conducive school physical environment was also found to be cross-sectionally associated with lower PSS and DS scores. Over time, mental health problems have shown a general increase among adolescents in the low SES group and a decrease among those in the high SES group. While school-related factors explained the improvement in mental health in the high SES group, we found such association only between parental support trends in PSS and DS, along with participation and trends in SA over time among adolescents in the low SES group.

Conclusions
The results show that school-related factors play significant roles in influencing adolescent mental health. The influence, however, varied across SES gradients over time. This suggests that working against inequities in school-related factors would help address inequities in mental health.
Hydrochemical Characterisation of Groundwaters in a Crystalline Basement Environment: The Case of Fractured Aquifers in the Poni Watershed in the South-West Region of Burkina Faso, West Africa
Authors: Hebie Adama , Kafando Sayoba , Nakolendousse Samuel 
Published: March 2024

The Poni watershed is located in the south-west of Burkina Faso. Its geology is made up of fractured crystalline and crystallophyllian basement, where fractured aquifers are the most exploited for water needs. The aim of this study is to determine the physico-chemical characteristics of the groundwater in the fractured aquifers of the Poni watershed in order to gain a better understanding of the mineralisation processes and hydrochemical properties of the groundwater in these aquifers. To do this, approaches based on the determination of Calcite Saturation Indices (CSI) and Dolomite Saturation Indices (DSI), Principal Component Analysis (PCA) and hydrochemical properties show that the majority of groundwater in the basin is undersaturated with respect to carbonates (79.37%) and divided into three families in relation to circulation speed: very slow circulation water (20.63%), slow circulation water (55.56%) and fast circulation water (23.81%). The approaches also show that the mineralisation of groundwater in the basin is governed by the acid hydrolysis of minerals in the surrounding rocks, residence time and surface inputs. They are characterised by calcic and magnesian bicarbonate facies (85.7%), calcic bicarbonate facies (6.35%), sodium and potassium bicarbonate facies (1.59%) and calcic and magnesian sulphate chlorides (6.35%).
Prior acute exercise restores postprandial fat oxidation in active cannabis users
Authors: Schubert Matthew M. , Terauds Samantha , Plant Maren , Handler Grace , Atkins Colin , Mendez Casandra 
Published: March 2024

AbstractData suggest cannabis users have similar or lower levels of blood lipids compared to nonusers. However, the extent to which cannabis users experience postprandial lipemia is not known. Eleven cannabis users and 11 nonusers completed either rest or 1 h of exercise at their ventilatory threshold the evening before a meal tolerance test (MTT). Substrate oxidation, blood pressure, and capillary blood were obtained before and every 30–60 min post‐meal for 3 h. Linear mixed models were utilized to examine differences in variables between groups, conditions, across time, and their interactions. Exercise led to increased fat oxidation post‐MTT (p < 0.05), with cannabis users exhibiting higher AUC compared to the control trial (p < 0.05). Exercise also caused significantly lower levels of triglycerides (p < 0.05). Metabolic flexibility was improved in cannabis users in the exercise trial only (p < 0.05). No effect of group, trial, or interactions were detected for other variables of interest (all p > 0.05). This study indicated that prior exercise improves lipid metabolism in cannabis users and nonusers after a high‐fat meal test. Cannabis users appear sensitive to the effects of exercise. Future studies should incorporate additional meals and variables related to cardiovascular health and metabolism.