bluuebunny/crossref_metadata_2025_split huggingface dataset:
REBOA (Resuscitative Endovascular Balloon Occlusion of the Aorta) im prähospitalen Einsatz – Präsentation zweier Fälle
Authors: Hilbert-Carius Peter , Siebenborn Tim , Bielert Marcus , Großstück Axel 
Published: April 2024

ZusammenfassungResuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) ist ein wenig
invasives Verfahren, um ein „internes“ Cross-Clamping der Aorta durchzuführen. Hierdurch
ist es entweder möglich, den Blutverlust bei nicht komprimierbaren Körperstammblutungen
zu reduzieren und den Patienten vor dem Verbluten zu retten oder im Rahmen der
Herz-Lungen-Wiederbelebung (CPR) den koronaren und zerebralen Perfusionsdruck zu erhöhen
und damit eventuell die ROSC-Rate und das neurologische Outcome zu verbessern. Aktuell
findet REBOA in Deutschland nur in einigen Traumazentren im Schockraum Anwendung und der
prähospitale Einsatz ist eher eine extrem seltene Ausnahme. Wir berichten über 2 Fälle,
in denen das Verfahren im Rahmen des RIBCAP-HEMS-Projektes (REBOA In Bleeding and
Cardiac Arrest in the Pre-hospital care by Helicopter Emergency Medical Service)
prähospital durch das Team eines Rettungshubschraubers der DRF Luftrettung jeweils bei
der CPR sowie beim Trauma angewendet wurde.
Thulium oder Holmium-Laser oder beides: wo geht die Reise hin?
Authors: Becker Benedikt , Hook Sophia , Gross Andreas J. , Rosenbaum Clemens , Filmar Simon , Herrmann Jonas , Netsch Christopher 
Published: April 2024

ZusammenfassungDer Holmium:YAG-Laser war in den letzten drei Jahrzehnten der Goldstandard für die Laserlithotripsie und seit Ende der 1990er Jahre auch für die Enukleation der Prostata. Nachdem die gepulsten Thulium-Faserlaser (TFL) ihre Wirksamkeit in in-vitro Experimenten demonstriert haben, wurden sie vor einigen Jahren auf dem Markt eingeführt. Die ersten klinischen Ergebnisse zu dem TFL für die Lithotripsie und die Enukleation sind sehr erfolgsversprechend. Neben dem TFL wurde auch ein gepulster Thulium:YAG-Festkörperlaser eingeführt, zu dem allerdings noch wenige klinische Daten vorliegen. Dieser Artikel zielt darauf ab, die wichtigsten technologischen Unterschiede zwischen dem Ho:YAG-Laser und den gepulsten Thuliumlaser zu überprüfen und die ersten klinischen Ergebnisse zur Steinlithotripsie und zur Laserenukleation gegenüberzustellen bzw. zu diskutieren.In-vitro-Studien zeigen eine technische Überlegenheit des TFL im Vergleich zum Ho:YAG-Laser. Da der TFL jedoch noch eine neue Technologie ist, stehen derzeit nur begrenzte Studien zur Verfügung und die optimalen Einstellungen für die Lithotripsie sind noch nicht festgelegt. Bei der Enukleation scheinen die Unterschiede des TFL zu einem Hochleistungs-Ho:YAG-Laser klinisch nicht relevant zu sein. Erste Studien zum gepulsten Tm:YAG-Laser zeigen zwar vielversprechende Ergebnisse, jedoch liegen noch keine vergleichenden Studien vor.Die gepulsten Thuliumlaser haben das Potenzial, eine Alternative zum Ho:YAG-Laser zu sein. Es sind jedoch noch weitere Studien erforderlich, um den optimalen Laser für die Enukleation und die Lithotripsie von Harnsteinen unter Berücksichtigung aller Parameter, einschließlich Wirksamkeit, Sicherheit und Kosten, zu bestimmen.
Vasorelaxant Activity of (2S)-Sakuranetin and Other Flavonoids Isolated from the Green Propolis of the Caatinga Mimosa tenuiflora
Authors: Son Ninh The , Gianibbi Beatrice , Panti Alice , Spiga Ottavia , Bastos Jairo Kenupp , Fusi Fabio 
Published: April 2024

AbstractSome in vitro and in vivo evidence is consistent with the cardiovascular beneficial activity of propolis. As the single actors responsible for this effect have never been identified, an in-depth investigation of flavonoids isolated from the green propolis of the Caatinga Mimosa tenuiflora was performed and their mechanism of action was described. A comprehensive electrophysiology, functional, and molecular docking approach was applied. Most flavanones and flavones were effective CaV1.2 channel blockers with a potency order of (2S)-sakuranetin > eriodictyol-7,3′-methyl ether > quercetin 3-methyl ether > 5,4′-dihydroxy-6,7-dimethoxyflavanone > santin > axillarin > penduletin > kumatakenin, ermanin and viscosine being weak or modest stimulators. Except for eriodictyol 5-O-methyl ether, all the flavonoids were also effective spasmolytic agents of vascular rings, kumatakenin and viscosine also showing an endothelium-dependent activity.
(2S)-Sakuranetin also stimulated KCa1.1 channels both in single myocytes and vascular rings. In silico analysis provided interesting insights into the mode of action of (2S)-sakuranetin within both CaV1.2 and KCa1.1 channels. The green propolis of the Caatinga Mimosa tenuiflora is a valuable source of multi-target vasoactive flavonoids: this evidence reinforces its nutraceutical value in the cardiovascular disease prevention arena.
Kommunikative Teilhabe aus der Perspektive von Menschen mit einer palliativen Krebserkrankung aufgrund von Kopf-Hals-Tumoren
Authors: Petry Jennifer , Marotzki Ulrike , Barthel Maria 
Published: April 2024

Zusammenfassung
Ziel der Studie Die Bedeutung von kommunikativer Teilhabe und das Erleben von Kommunikationssituationen wird aus der Perspektive von Menschen mit einem palliativen Kopf-Hals-Tumor dargestellt.
Methodik Es wurden episodische Interviews mit fünf Menschen mit Kopf-Hals-Tumor geführt, die sich in ambulanter oder vorübergehend stationärer palliativer Behandlung befanden. Die Auswertung folgte der phänomenologischen Methodologie und der Grounded Theory.
Ergebnisse Menschen mit einem palliativen Kopf-Hals-Tumor erleben Kommunikationssituationen als kommunikatives Ausbalancieren auf den Ebenen „Dabei zu sein“, „Umgang mit Entscheidungen“ und „Beziehungsgestaltung“. Es wird beeinflusst von intra- und extrapersonalen Faktoren sowie der jeweiligen Situationsstruktur.
Schlussfolgerung Kommunikative Teilhabe steht für eine selbstbestimmte Gestaltung von Alltags- und Versorgungssituationen. In der Behandlung können Betroffene zu einer individuellen kommunikativen Teilhabe befähigt werden, was zu einer gesteigerten Lebensqualität führen kann.
The Quadrangular Cartilage in Rhinoplasty: A Surgically Focused CT Dimensional Analysis of Black African and Caucasian Populations
Authors: Pisapia Francesco , Cottone Giuseppe , Stutterheim James , Robotti Enrico , McIntosh Cameron 
Published: April 2024

AbstractThe apparent lack of quadrangular cartilage in Black African noses is commonly observed both from a radiological and clinical point of view. To the best of our knowledge, only a few research papers have been conducted on the facial proportions and structural anatomy of black people of Southern and Eastern Africa. The aim of this retrospective comparative study is a radiological assessment of the total amount of septal quadrangular cartilage by measuring its area in sagittal CT views, in two selected Black South African and Caucasian (CA) samples and the comparison with the literature in our hands. Statistical analysis was conducted, categorical variables are shown as frequencies and percentages, while continuous variables as means and standard deviations. Normal distribution of variables was verified using the Shapiro–Wilk test or by means of skewness and kurtosis values. Differences among unpaired groups were evaluated using the independent Student's t-test for normally distributed data (complemented by the Cohen's d to show the effect size with the following cutoff: d = 0.2, “small” effect size; d = 0.5, “medium” effect size; d = 0.8, “large” effect size) and Mann–Whitney U test in case of non-normal distribution. Statistical significance was defined as p < 0.05 setting the α-error probability at 5%. This study shows that, on average, there is 30% more cartilage available in CA compared with Black African noses and confirms the apparent lack of quadrangular cartilage and in Black African noses which is commonly observed in surgery. The need for an adequate amount of autologous septal cartilage makes cartilage availability a major concern before surgery and being able to preoperative accurately measure the amount of septal cartilage that is available to be harvested for other grafts in the surgery is essential.
Over-the-scope clip as first-line treatment of peptic ulcer bleeding: a multicenter randomized controlled trial (TOP Study)
Authors: Soriani Paola , Biancheri Paolo , Bonura Giuliano Francesco , Gabbani Tommaso , Rodriguez de Santiago Enrique , Dioscoridi Lorenzo , Andrisani Gianluca , Luigiano Carmelo , Deiana Simona , Rainer Joachim , Del Buono Mariagrazia , Amendolara Rocco , Marino Massimiliano , Hassan Cesare , Repici Alessandro , Manno Mauro 
Published: April 2024

Abstract
Background First-line over-the-scope (OTS) clip treatment has shown higher efficacy than standard endoscopic therapy in acute nonvariceal upper gastrointestinal bleeding (NVUGIB) from different causes. We compared OTS clips with through-the-scope (TTS) clips as first-line mechanical treatment in the specific setting of peptic ulcer bleeding.
Methods We conducted an international, multicenter randomized controlled trial on consecutive patients with suspected NVUGIB. Patients with Forrest Ia–IIb gastroduodenal peptic ulcer were randomized 1:1 to OTS clip or TTS clip treatment. The primary outcome was the rate of 30-day rebleeding after successful initial hemostasis. Secondary outcomes included the rates of successful initial hemostasis and overall clinical success, defined as the composite of successful initial hemostasis and no evidence of 30-day rebleeding.
Results 251 patients were screened and 112 patients were randomized to OTS (n = 61) or TTS (n = 51) clip treatment. The 30-day rebleeding rates were 1.6% (1/61) and 3.9% (2/51) in patients treated with OTS clips and TTS clips, respectively (Kaplan–Meier log-rank, P = 0.46). Successful initial hemostasis rates were 98.4% (60/61) in the OTS clip group and 78.4% (40/51) in the TTS clip group (P = 0.001). Overall clinical success rates were 96.7% (59/61) with OTS clips and 74.5% (38/51) with TTS clips (P = 0.001).
Conclusions Low rates of 30-day rebleeding were observed after first-line endoscopic treatment of acute peptic ulcer bleeding with either OTS or TTS clips. However, OTS clips showed higher efficacy than TTS clips in achieving successful initial hemostasis and overall clinical success.
A Rare Case of Primary Sarcoma Arising Within Free Muscle Transfer
Authors: Jain Anchal , Rafique Bilal , Durrani Amer J. , Abood Ahid 
Published: April 2024

AbstractSoft tissue sarcomas are one of the rarest forms of cancer. We describe a unique case of a 35-year-old patient who sustained an open lower limb fracture requiring an intramedullary nail and free latissimus dorsi (LD) muscle flap reconstruction. He had a complex postoperative course including osteomyelitis, a refracture, and chronic pain. Eleven years following the injury, he presented with pain and localized swelling around the flap. Histological analysis confirmed a rhabdomyosarcoma within the LD muscle and he underwent a transfemoral amputation. He is now in remission and walks on a prosthesis pain-free.
Bryophyllum pinnatum Inhibits Oxytocin and Vasopressin Signaling in Myometrial Cells
Authors: Zurfluh Leonie , Duvaud Lauriane , Inci Nejla , Potterat Olivier , Simões-Wüst Ana Paula , Mosbacher Johannes 
Published: April 2024

AbstractThe medicinal plant Bryophyllum pinnatum was previously shown to block oxytocin (OT)-induced signals in myometrial cells, consistent with its tocolytic effect observed in patients. OT activates not only OT receptors but also V1A receptors, two receptors with high receptor homology that are both expressed in the myometrium and play a crucial role in myometrial contraction signaling. We aimed to study the molecular pharmacology of B. pinnatum herbal preparations using specific receptor ligands, the human myometrial cell line hTERT-C3, and cell lines expressing recombinant human OT and V1A receptors.We found that press juice from B. pinnatum (BPJ) inhibits both OT- and vasopressin (AVP)-induced intracellular calcium increases in hTERT-C3 myometrial cells. In additional assays performed with cells expressing recombinant receptors, BPJ also inhibited OT and V1A receptor-mediated signals with a similar potency (IC50 about 0.5 mg/mL). We further studied endogenous OT- and AVP-sensitive receptors in hTERT-C3 cells and found that OT and AVP stimulated those receptors with similar potency (EC50 of ~ 1 nM), suggesting expression of both receptor subtypes. This interpretation was corroborated by the antagonist potencies of atosiban and relcovaptan that we found. However, using qPCR, we almost exclusively found expression of OT receptors suggesting a pharmacological difference between recombinant OT receptors and native receptors expressed in hTERT-C3 cells.In conclusion, we show that B. pinnatum inhibits both OT and AVP signaling, which may point beyond its tocolytic effects to other indications involving a disbalance in the vasopressinergic system.
Approaches to the Management of Synkinesis: A Scoping Review
Authors: Zubler Cédric , Punreddy Ankit , Mayorga-Young Danielle , Leckenby Jonathan , Grobbelaar Adriaan O. 
Published: April 2024

AbstractPostparalysis facial synkinesis (PPFS) can develop in any facial palsy and is associated with significant functional and psychosocial consequences for affected patients. While the prevention of synkinesis especially after Bell's palsy has been well examined, much less evidence exists regarding the management of patients with already established synkinesis. Therefore, the purpose of this review is to summarize the available literature and to provide an overview of the current therapeutic options for facial palsy patients with established synkinesis. A systematic literature review was undertaken, following the Preferred Reporting Items of Systematic Reviews and Meta-analyses 2020 guidelines. MEDLINE via PubMed and Cochrane Library were searched using the following strategy: ([facial palsy] OR [facial paralysis] OR [facial paresis]) AND (synkinesis) AND ([management] OR [guidelines] OR [treatment]). The initial search yielded 201 articles of which 36 original papers and 2 meta-analyses met the criteria for inclusion. Overall, the included articles provided original outcome data on 1,408 patients. Articles were divided into the following treatment categories: chemodenervation (12 studies, 536 patients), facial therapy (5 studies, 206 patients), surgical (10 studies, 389 patients), and combination therapy (9 studies, 278 patients). Results are analyzed and discussed accordingly. Significant heterogeneity in study population and design, lack of control groups, differences in postoperative follow-up, as well as the use of a variety of subjective and objective assessment tools to quantify synkinesis prevent direct comparison between treatment modalities. To date, there is no consensus on how PPFS is best treated. The lack of comparative studies and standardized outcome reporting hinder our understanding of this complex condition. Until higher quality scientific evidence is available, it remains a challenge best approached in an interdisciplinary team. An individualized multimodal therapeutic concept consisting of facial therapy, chemodenervation, and surgery should be tailored to meet the specific needs of the patient.
Linking Patient Encounters across Primary and Ancillary Electronic Health Record Systems: A Comparison of Two Approaches
Authors: Davila Marcos A. , Sholle Evan T. , Fuld Xiaobo , Israel Mark L. , Cole Curtis L. , Campion Thomas R. 
Published: April 2024

Abstract
Background To achieve scientific goals, researchers often require integration of data from a primary electronic health record (EHR) system and one or more ancillary EHR systems used during the same patient care encounter. Although studies have demonstrated approaches for linking patient identity records across different EHR systems, little is known about linking patient encounter records across primary and ancillary EHR systems.
Objectives We compared a patients-first approach versus an encounters-first approach for linking patient encounter records across multiple EHR systems.
Methods We conducted a retrospective observational study of 348,904 patients with 533,283 encounters from 2010 to 2020 across our institution's primary EHR system and an ancillary EHR system used in perioperative settings. For the patients-first approach and the encounters-first approach, we measured the number of patient and encounter links created as well as runtime.
Results While the patients-first approach linked 43% of patients and 49% of encounters, the encounters-first approach linked 98% of patients and 100% of encounters. The encounters-first approach was 20 times faster than the patients-first approach for linking patients and 33% slower for linking encounters.
Conclusion Findings suggest that common patient and encounter identifiers shared among EHR systems via automated interfaces may be clinically useful but not “research-ready” and thus require an encounters-first linkage approach to enable secondary use for scientific purposes. Based on our search, this study is among the first to demonstrate approaches for linking patient encounters across multiple EHR systems. Enterprise data warehouse for research efforts elsewhere may benefit from an encounters-first approach.
The reduction of effective feedback reception due to negative emotions in appeals
Authors: Zhang Peide , Peng Binbin , Mi Zhifu , Lin Zhongguo , Du Huibin , Cheng Lu , Zhou Xiafei , Cao Guozhi 
Published: April 2024

AbstractCitizens’ daily appeals are generally accompanied by negative sentiment, yet little is known about the impact of negative emotions on official response behaviors in a closed online environment. This study analyzed over 2.6 million environmental appeals and their handling records from China’s closed complaint platform to explore how individual negative emotions affect department response behaviors. The results showed that negative emotions could cause departments to respond more rapidly and decrease the likelihood of the citizens receiving department assistance. Whether the appeal can be handled efficiently also depends on the oversight of the department and the respondent’s implementation. Negative emotion towards the department is more likely to lead to a failed handling of the appeal. In addition, when citizens face serious hazards, such as health risks, negative emotions are understandable. Negative emotional appeals concerning health risks receive more time and effective intervention by departments. This paper sheds light on the role of negative emotions in shaping feedback and provides suggestions for improving individual appeal expression and departmental response behavior.
A bibliometric analysis of knowledge mapping in Chinese education digitalization research from 2012 to 2022
Authors: Shi Rui , Wan XiuLan 
Published: April 2024

AbstractThe digital transformation of education should be continuously promoted to guarantee its sustainable development. Extensive research has been conducted in this field but has not comprehensively addressed Chinese education digitalization. To fill this research gap, discover the gaps between Chinese and international research on the digitization of education and provide well-founded, innovative ideas for future research, we perform a bibliometric analysis of knowledge mapping in Chinese education digitalization. WOS and CNKI databases were used to gather literature on Chinese education digitalization research from 2012 to 2022. CiteSpace was used to draw a knowledge map of Chinese education digitalization research through co-occurrence analysis of core authors, issuing institutions and regions and cluster analysis and burst terms analysis of keywords, combined with intensive manual studying of the literature. The results show the research status and hot spots of Chinese education digitalization research are divided into four dimensions: studies of lifelong education research in digital open universities and the online teaching transformation in higher education; studies of digital educational publications, the development and application of digital learning resources in vocational colleges and universities, and the equity of basic education resources in the digital context; studies on artificial intelligence technology empowering the digital transformation of education in China; and studies of digital integration of production and teaching in rural revitalization and improvement of digital literacy of university students and faculty. Future digital education research trends in China are likely to focus on the normalization of online education; the development of online education resources in the context of new infrastructure; “new technology plus education”; the impact of digital games on education; a more diversified digital divide in education; and digital rights, digital ethics, digital maturity and the Global Digital Education Development Index.
Design of optical telescopes for laser field wavefront reconstruction in gravitational-wave detectors
Authors: Allocca A , Genin E , Mantovani M , Chiummo A 
Published: April 2024

Abstract
Pick-off beams in Interferometric Gravitational Wave Detectors are often used to derive information on the field circulating in the interferometer. In order to retrieve the wavefront of the field at some chosen location, an optical system has to be deployed so to image the desired field characteristics to an optical bench and ultimately to suitable sensors. In this paper, we detail the requirements in terms of Gouy Phase and ABCD matrix for such an optical system to provide the correct information. We show also that by designing the optical system with adequate Gouy Phase evolution, the same kind of transformation holds true not only for the fundamental Gaussian mode, but also for both even and odd Higher Order Modes (HOMs) of the main interferometer beam. This is important because these HOMs are excited by the aberrations of the optical elements in the interferometer, and carry the information one is interested to. Simulations with two tools (Finesse and Zemax OpticsStudio®) are provided to confirm the analytical results obtained using Gaussian modes expansion of a generic field.
Symmetry and instability of marginally outer trapped surfaces
Authors: Booth Ivan , Cox Graham , Margalef-Bentabol Juan 
Published: April 2024

Abstract
We consider an initial data set having a continuous symmetry and a marginally outer trapped surface (MOTS) that is not preserved by this symmetry. We show that such a MOTS is unstable except in an exceptional case. In non-rotating cases we provide a Courant-type lower bound on the number of unstable eigenvalues. These results are then used to prove the instability of a large class of exotic MOTSs that were recently observed in the Schwarzschild spacetime. We also discuss the implications for the apparent horizon in data sets with translational symmetry.
Faster than a speeding bullet—the 2023 Physics Nobel Prize
Authors: Vrakking Marc 
Published: April 2024

Abstract
Attosecond physics is a novel research field that pursues a better understanding of electron dynamics in atoms, molecules and condensed matter by means of pump-probe experiments where the motion of electrons are tracked with attosecond (1 as = 10−18 s) time resolution. The 2023 Physics Nobel Prize was awarded to three experimental pioneers of the field, who developed the key methods to generate and characterize attosecond pulses.