bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concentrations of Saxitoxin and Tetrodotoxin in Three Species of Puffers from the Indian River Lagoon, Florida, the Location for Multiple Cases of Saxitoxin Puffer Poisoning from 2002 to 2004
Authors: Deeds Jonathan R. , White Kevin D. , Etheridge Stacey M. , Landsberg Jan H. 
Published: August 2008

AbstractIn response to multiple, unexpected cases of saxitoxin poisoning that started in January 2002, southern puffers Sphoeroides nephelus, checkered puffers S. testudineus, and bandtail puffers S. spengleri were collected from April to August 2002 from several locations in the Indian River Lagoon (IRL), Florida. Fish were analyzed for saxitoxin (STX) and tetrodotoxin (TTX) content in muscle, liver, and gonad tissues by means of the liquid chromatography‐electrospray ionization‐mass spectrometry method in multiple reactions monitoring mode. Spatial, species, and tissue‐specific differences in toxin content and composition were found among these puffer species in the IRL. Southern puffers from the northern IRL had the highest concentrations of STX, muscle being the most contaminated tissue (1,770 ± 159 μg/100 g tissue [mean ± SD]; n = 3). Southern puffers from the Banana River and central IRL had lower amounts of STX in all tissues tested. Nearly all southern puffer tissues tested had only trace amounts of TTX. Both checkered and bandtail puffers from the central and southern IRL had higher concentrations of TTX than of STX in all tissues, checkered puffer livers being the most toxic (6,075 ± 3,283 μg/100 g tissue; n = 3). For comparison, U.S. mid‐Atlantic northern puffers S. maculatus (n = 10) were tested and found to contain no detectable amounts of STX or TTX. This research confirms that STX and not TTX was responsible for 28 poisoning cases in southern puffers from the northern IRL between 2002 and 2004, and it describes for the first time the relative distribution of STX and TTX in U.S. East Coast puffers.
Boat Electrofishing Relative to Anode Arrangement
Authors: Miranda L. E. , Kratochvíl M. 
Published: August 2008

AbstractWe assessed the effect of boom (i.e., anode) arrangement (a single boom and double booms spaced 1.3, 1.9, and 3.2 m apart) on the characteristics of the electric field formed ahead of an electrofishing boat as well as on fish catch. Anode arrangement affected the lengthwise and crosswise characteristics of the field. As a general rule, rearranging the anodes from a single boom located centrally to a double‐boom system with broadly separated anodes shifted the strength of the field outward (away from the center) and forward (away from the boat). The highest voltage gradients occurred when the anodes had the greatest separation. Catch rates varied by boom arrangement, increasing as boom separation increased. Differences in species and length selectivity with respect to boom arrangement were minor. We suggest that the double‐boom arrangement with the booms placed about 1.9 m apart (but no more than about 2.5 m) is suitable for most electrofishing applications.
Effects of dietborne copper and silver on reproduction by Ceriodaphnia dubia
Authors: Kolts Jason M. , Boese Connie J. , Meyer Joseph S. 
Published: August 2008

Abstract
Recent studies have indicated the potential for dietborne metals as an important exposure pathway for metal toxicity in freshwater organisms. We conducted a study in which freshwater cladocerans (Ceriodaphnia dubia) were fed green algae (either Pseudokirchneriella subcapitata or Chlorella vulgaris) that were grown in Ag- or Cu-contaminated media. In one series of toxicity tests patterned after the U.S. Environmental Protection Agency's three-brood C. dubia chronic toxicity test, we exposed C. dubia to waterborne Ag or Cu while feeding them normal amounts of uncontaminated yeast–Cerophyll®–trout chow (YCT) slurry and either algae grown in standard media or algae grown in standard media supplemented with Ag or Cu (added as AgNO3 or CuSO4·5H2O). These parallel tests demonstrated that dietborne metal did not contribute to survival or reproduction effects beyond the effects caused by waterborne metal alone. We also conducted dietborne-only toxicity tests patterned after two other recently published experimental designs in which 1) C. dubia were fed only metal-contaminated algae for 4 h, transferred to fresh water, and fed uncontaminated algae and YCT slurry for the duration of the three-brood test or 2) C. dubia were fed standard amounts of metal-contaminated algae and uncontaminated YCT slurry for the entire three-brood test. In contrast to previous studies, we did not find consistent dietborne metal toxicity or standard concentration–response relationships in those two experiments. Instead, among-experiment variation in intracellular partitioning of metals in the algae fed to the C. dubia, among-laboratory differences in experimental procedures, selective feeding by C. dubia to avoid metal-contaminated algae, an interaction between reproductive status of the C. dubia and dietborne metal concentration, or a combination of these might help explain the apparently inconsistent results.
Whole sediment toxicity identification evaluation tools for pyrethroid insecticides: III. Temperature manipulation
Authors: Weston Donald P. , You Jing , Harwood Amanda D. , Lydy Michael J. 
Published: August 2008

AbstractSince the toxicity of pyrethroid insecticides is known to increase at low temperatures, the use of temperature manipulation was explored as a whole-sediment toxicity identification evaluation (TIE) tool to help identify sediment samples in which pyrethroid insecticides are responsible for observed toxicity. The amphipod Hyalella azteca is commonly used for toxicity testing of sediments at a 23°C test temperature. However, a temperature reduction to 18°C doubled the toxicity of pyrethroids, and a further reduction to 13°C tripled their toxicity. A similar response, though less dramatic, was found for 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane (DDT), and dissimilar temperature responses were seen for cadmium and the insecticide chlorpyrifos. Tests with field-collected sediments containing pyrethroids and/or chlorpyrifos showed the expected thermal dependency in nearly all instances. The inverse relationship between temperature and toxicity provides a simple approach to help establish when pyrethroids are the principal toxicant in a sediment sample that could be used as a supplemental tool in concert with chemical analysis or other TIE manipulations. The phenomenon appears to be, in part, a consequence of a reduced ability to biotransform the toxic parent compound at cooler temperatures. The strong dependence of pyrethroid toxicity on temperature has important ramifications for predicting their environmental effects, and the standard test temperature of 23°C dramatically underestimates risk to resident fauna during the cooler months.
Effect of triclosan on microbial activity in australian soils
Authors: Waller Natasha J. , Kookana Rai S. 
Published: August 2008

Abstract
Triclosan (TCS) antimicrobial compound is used in personal care products such as shampoos and soaps. The TCS compound can survive the treatment process and is often present in the sewage effluent and biosolids. We investigated the impact of TCS upon selected microbiological and biochemical parameters in two contrasting Australian soils. Substrate-induced respiration and nitrification, plus activities of four enzymes (relevant for carbon and nitrogen turnover), were measured using Organisation for Economic Co-operation and Development protocols after exposing soils to TCS at concentrations of 0, 1, 5, 10, 50, and 100 mg/kg of soil. Respiration in the sandy soil was not affected by the addition of TCS, but in clay soil it decreased to TCS at 50 mg/kg of soil. The nitrification process was affected in both soils. In the sandy soil, TCS showed a negative effect on the nitrate and nitrite production at 5 mg/kg. In contrast, in the clay soil, the effect was noticeable only at concentrations greater than 50 mg/kg. The response of four enzymes (acid and alkali phosphatase, β-glucosidase, and chitinase) in the two soils was variable, and only β-glucosidase showed some response to TCS addition. The study demonstrated that TCS at concentrations below 10 mg/kg can disturb the nitrogen cycle in some soils. A first-tier hazard assessment highlighted the need for further work on TCS impact on soil microorganisms.
Aldose Reductase Genotypes and Cardiorenal Complications
Authors: So Wing-Yee , Wang Ying , Ng Maggie C.Y. , Yang Xilin , Ma Ronald C.W. , Lam Vincent , Kong Alice P.S. , Tong Peter C.Y. , Chan Juliana C.N. 
Published: August 2008

OBJECTIVE—We report the independent risk association of type 2 diabetic nephropathy with the z−2 allele of the 5′-(CA)n microsatellite and C-106T promoter polymorphisms of the aldose reductase gene (ALR2) using a case-control design. In this expanded cohort, we examined their predictive roles on new onset of cardiorenal complications using a prospective design.
RESEARCH DESIGN AND METHODS—In this 8-year prospective cohort of 1,074 type 2 diabetic patients (59% male, median age 61 years; disease duration 7 years) with an observation period of 8,592 person-years, none had clinical evidence of coronary heart disease (CHD) or chronic kidney disease at recruitment. The renal end point was defined as new onset of estimated glomerular filtration rate &lt;60 ml/min per 1.72 m2 or hospitalizations with dialysis or death due to renal disease, and CHD was defined as hospitalizations with myocardial infarction, ischemic heart disease, or related deaths.
RESULTS—After controlling for baseline risk factors and use of medications, we found that the ALR2 z−2 allele of (CA)n microsatellite carriers had increased risk of renal (hazard ratio 1.53 [95% CI 1.14–2.05], P = 0.005) or combined cardiorenal (1.31 [1.01–1.72], P = 0.047) end points. Carriers of the ALR2 C-106T polymorphism also had increased risk of renal (1.54 [1.15–2.07], P = 0.004) and cardiorenal (1.49 [1.14–1.95], P = 0.004) end points. Compared with noncarriers, patients with two risk-conferring genotypes had a twofold increased risk of renal (2.41 [1.57–3.70], P &lt; 0.001) and cardiorenal (1.94 [1.29–2.91], P = 0.002) end points.
CONCLUSIONS—In Chinese type 2 diabetic patients, genetic polymorphisms of ALR2 independently predicted new onset of renal and cardiorenal end points, with the latter being largely mediated through renal disease.
Analysis of auditory and neurologic effects associated with ventral bulla osteotomy for removal of inflammatory polyps or nasopharyngeal masses in cats
Authors: Anders Brendan B. , Hoelzler Michael G. , Scavelli Thomas D. , Fulcher Ryan P. , Bastian Richard P. 
Published: August 2008

Abstract
Objective—To determine whether cats undergoing ventral bulla osteotomy (VBO) for removal of inflammatory polyps or nasopharyngeal masses have altered ability to hear and whether polyp or mass removal affects auditory function as measured via air-conducted brainstem auditory evoked response (BAER).
Design—Prospective case series.
Animals—21 cats.
Procedures—Cats were sedated and had otic-oral examinations to confirm presence of nasopharyngeal masses; BAER testing was done immediately prior to and following the completion of a VBO and polyp or mass removal. Recheck examination, including otic examination and BAER in sedated cats, was performed when possible.
Results—17 cats met final inclusion criteria, and long-term follow-up was available for 15. Six of 17 had deafness as measured via air-conducted BAER prior to surgery. Mean followup time was 161 days, and there was no change from presurgical status in auditory ability in any cat. Eleven of 17 developed ipsilateral Horner syndrome in the immediate postoperative period, and 1 of 16 had polyp regrowth.
Conclusions and Clinical Relevance—Results suggested that in cats, VBO for removal of inflammatory polyps or masses is unlikely to affect hearing as measured via air-conducted BAER. Most cats developed short-term Horner syndrome. Cats with deafness prior to surgery did not regain auditory function. Ventral bulla osteotomy to remove nasopharyngeal polyps or masses provided no functional advantage with regard to restoration of hearing, compared with other surgical techniques. Polyp recurrence and long-term adverse effects were uncommon.
Failure to identify an association between serologic or molecular evidence of Bartonella infection and idiopathic rhinitis in dogs
Authors: Hawkins Eleanor C. , Johnson Lynelle R. , Guptill Lynn , Marr Henry S. , Breitschwerdt Edward B. , Birkenheuer Adam J. 
Published: August 2008

Abstract
Objective—To determine whether infection with or exposure to Bartonella spp was associated with idiopathic rhinitis in dogs.
Design—Case-control study.
Animals—44 dogs with idiopathic nasal discharge and 63 age- and weight-matched control dogs without nasal discharge and no clinical signs of bartonellosis.
Procedures—Serum was tested for antibodies against Bartonella henselae and Bartonella vinsonii subsp berkhoffii with indirect fluorescent antibody assays. Blood was tested for Bartonella DNA with a PCR assay.
Results—Results of the antibody and PCR assays were negative for all 44 dogs with idiopathic nasal discharge. One control dog had antibodies against B henselae; a second control dog had positive PCR assay results. We did not detect a significant association between assay results and group designation.
Conclusions and Clinical Relevance—The present study failed to confirm an association between idiopathic rhinitis and exposure to or infection with Bartonella spp in dogs. Findings do not rule out the possibility that Bartonella infection may cause nasal discharge in some dogs, but the failure to find any evidence of exposure to or infection with Bartonella spp in dogs with idiopathic nasal discharge suggested that Bartonella infection was not a common cause of the disease.
Evaluation of use of human albumin in critically ill dogs: 73 cases (2003–2006)
Authors: Trow Amy V. , Rozanski Elizabeth A. , deLaforcade Armelle M. , Chan Daniel L. 
Published: August 2008

Abstract
Objectives—To evaluate the use of human albumin in critically ill dogs.
Design—Retrospective case series.
Animals—73 client-owned hospitalized dogs.
Procedures—Medical records of dogs that received human albumin were reviewed to assess effects of the use of human albumin on serum albumin concentration, colloid osmotic pressure, and total protein concentration; determine the relationships between these variables and outcome; and assess its safety. Data for signalment, diagnoses, physiologic variables, dosage, amount of crystalloid fluid administered prior to human albumin administration, complications, and outcome were reviewed. Additionally, pre- and postadministration values for serum albumin, colloid osmotic pressure, and total protein were recorded.
Results—Administration of human albumin resulted in significant changes in serum albumin, colloid osmotic pressure, and total protein. The serum albumin, total protein, degree of improvement in serum albumin, colloid osmotic pressure, and dosage of human albumin were significantly greater in survivors. Seventeen of 73 (23%) dogs had at least 1 complication that could be potentially associated with the administration of human albumin that occurred during or immediately following administration of human albumin. Three of 73 (4%) dogs had severe delayed complications.
Conclusions and Clinical Relevance—Administration of human albumin significantly increased serum albumin, and total protein concentrations and colloid osmotic pressure, especially in survivors. Because of the high mortality rate of the study population and other confounding factors, it was uncertain whether complications were associated with the underlying disease or with human albumin administration. Acute and delayed complications may have been under-recognized.
Outbreak of Salmonella enterica serotype Newport in a beef cow-calf herd associated with exposure to bovine viral diarrhea virus
Authors: Daly Russell F. , Neiger Regg D. 
Published: August 2008

Abstract
Case Description—Severe disease and death in cows and calves affected 1 of 3 separate groups (A, B, and C) of cattle on a commercial cow-calf operation.
Clinical Findings—Clinical illness consisting of severe watery and bloody diarrhea, dehydration, weakness, and death affected adult cows and calves in 1 group (group B). Salmonella enterica serotype Newport was recovered from tissues of cows and calves from group B.
Treatment and Outcome—Despite supportive and antimicrobial treatment of cattle in group B, cow mortality rate attributable to salmonellosis in that group was 7.9% (32/407); calf mortality rate was 14.4% (52/361). None of the cows in Groups A or C died, and the calf mortality rate in those groups was low. Salmonella enterica serotype Newport was recovered from pooled fecal samples subsequently collected from each group of cows. Bovine viral diarrhea virus (BVDV) antigen was identified in an ear notch sample collected from a necropsied calf from group B. Subsequently, ear notch specimens from cattle in all 3 groups were tested for BVDV antigen. A significantly higher proportion of calves persistently infected with BVDV was identified in group B (8/295 [2.7%]), compared with the proportion in groups A and C combined (1/287 [0.3%]).
Clinical Relevance—Outbreaks of disease attributable to Salmonella Newport infection in beef cattle are unusual. Because of the immunosuppressive nature of BVDV, the possibility of animals persistently infected with BVDV within the herd should be considered during investigation of unusual outbreaks of infectious diseases.
Sibling history of asthma is a risk factor for pain in children with sickle cell anemia
Authors: Field Joshua J. , Macklin Eric A. , Yan Yan , Strunk Robert C. , DeBaun Michael R. 
Published: August 2008

AbstractThe basis of the association between asthma and an increased rate of pain among children with sickle cell anemia (SCA) is unclear. To provide evidence for a familial contribution to this observation, we tested the hypothesis that a family history of asthma is associated with an increased pain rate. Using data from the Cooperative Study for Sickle Cell Disease (CSSCD), we identified 211 children with SCA with asthma history of the parents and siblings. A sibling history of asthma was associated with a greater rate of pain (mean rate ratio = 2.48, 95% CI = 1.6–4.0; P < 0.001) when compared with children without a sibling history of asthma. Parental history of asthma was not associated an increase rate of pain (mean ratio = 1.51, 95% CI= 0.92–2.62; P = 0.12). Further studies are needed to examine genetic and/or environmental risks for asthma as potential contributors to pain in children with SCA. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.
Hemostatic complications of angiogenesis inhibitors in cancer patients
Authors: Elice Francesca , Jacoub Jack , Rickles Frederick R. , Falanga Anna , Rodeghiero Francesco 
Published: August 2008

AbstractTumor vasculature and tumor‐associated neo‐angiogenesis have recently become major targets for rational drug design of antineoplastic agents. Five such agents with angiogenesis inhibiting activity (thalidomide, lenalidomide, bevacizumab, sunitinib, sorafenib) have already obtained US Food and Drug Administration approval for clinical use and many others have entered clinical trials. Vascular complications, including venous or arterial thromboembolism and hemorrhage, have emerged as relevant toxicities in several clinical trials with angiogenesis inhibitors. Given the well‐known interplay between the blood clotting system, angiogenesis, and tumor growth, a better understanding of the impact of these new drugs on overall hemostatic balance is required. In this brief overview, we discuss the incidence of hemostatic complications, the likely pathogenetic mechanisms involved, and the critical need to establish in randomized clinical trials the usefulness of thrombosis prophylaxis to prevent these complications. Careful documentation of hemostatic complications during treatment with each of the new antiangiogenic drugs is warranted. Further studies are urgently required to better define the causal association of these new agents with hemostatic complications and to establish the best prophylactic strategy. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.
Fabrication and characterization of a novel polypropylene/poly(vinyl alcohol)/aluminum hybrid layered assembly for high‐performance fibrous insulation
Authors: Wu Huijun , Fan Jintu , Qin Xiaohong , Mo Sam , Hinestroza Juan P. 
Published: August 2008

AbstractA novel hybrid layered assembly based on aluminum‐coated poly(vinyl alcohol) (PVA) nanofibers supported on a polypropylene (PP) web was fabricated via electrospinning and physical vapor deposition. The PVA nanofibers and coated aluminum were characterized by field emission scanning electron microscopy and transmission electron microscopy. The results indicate that PVA nanofibers approximately 430 nm in diameter and an aluminum coating approximately 37 nm in thickness were successfully embedded on the supporting PP web. Fourier transform infrared spectra and the water vapor transmission rate were used to determine the IR spectral transmission and water vapor transmission through the materials with or without the nanofiber or metal coating, respectively. Compared to the uncoated PP web, the novel hybrid layered assembly showed a significant increase in thermal radiation extinction due to both the radiation reflection of the metal coating and the radiation absorption of the nanofibers without noticeable weight gain or water vapor permeable deterioration. This method represents a simple and practical approach for the production of a lightweight hybrid layered assembly that is highly beneficial in the efficient reduction of heat loss in low‐density fibrous insulations without a noticeable deterioration in the water vapor permeability and that could be used for wide applications such as protective clothing, sleeping bags, building construction, and aircraft. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Prospective study of colonic irrigation for the treatment of defaecation disorders
Authors: Koch S M P , Melenhorst J , van Gemert W G , Baeten C G M I 
Published: August 2008

Abstract

Background
Retrograde colonic irrigation is a possible treatment for defaecation disorders when conservative treatment or surgery has failed. The aim of this prospective study was to investigate its effectiveness.

Methods
Patients were divided into three groups: those with faecal incontinence (A), constipation (B) or both (C). The Biotrol® Irrimatic pump or the irrigation bag was used for colonic irrigation. Patients completed a questionnaire at baseline and after 3, 6 and 12 months, as well as a Short Form 36 health survey and an American Society of Colon and Rectal Surgery quality of life questionnaire at baseline and after 6 months.

Results
The study included 39 patients (26 women; mean age 58·0 years). In group A, 11 of 18 patients were pseudocontinent for faeces at 3 months (P &lt; 0·001). Parks' incontinence scores decreased for all patients in this group at 3 months (P &lt; 0·001), 6 months (P = 0·036) and 1 year (P = 0·005). In group B, three of ten patients reported a major improvement. The mean score for the feeling of incomplete evacuation decreased at 3 months (P = 0·007), 6 months (P = 0·013) and 1 year (P = 0·036). In group C, six of ten patients became pseudocontinent for faeces (P = 0·009) and three reported improvement in constipation. The overall quality of life scores improved (P = 0·012).

Conclusion
Retrograde colonic irrigation is an undervalued but effective alternative treatment for intractable defaecation disorders.