bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Effect Do Goal Setting Interventions Have on Physical Activity and Psychological Outcomes in Insufficiently Active Adults? A Systematic Review and Meta-Analysis
Authors: Garstang Katie R. , Jackman Patricia C. , Healy Laura C. , Cooper Simon B. , Magistro Daniele 
Published: April 2024

Background: Goal setting is commonly used for promoting physical activity (PA) among insufficiently active individuals. Previous reviews have analyzed the effects of goal setting on PA, but the purpose of this systematic review was to examine the concurrent effects of goal setting on PA and psychological outcomes in insufficiently active individuals to support interventions aiming to produce sustained PA behavior change. Methods: In this review (PROSPERO: CRD42021243970), we identified 13 studies with 1208 insufficiently active adults that reported the effects of goal-setting interventions (range 3–24 wk) on both PA and psychological outcomes (eg, self-efficacy, motivation, and affect). We used meta-analysis and narrative synthesis to analyze these effects. Results: All goals used in the included studies were specific goals. Setting specific goals had a large, positive effect on PA (g [standard mean difference] = 1.11 [P < .001]; 95% confidence interval, 0.74–1.47), but only a small, positive effect on the combined psychological outcomes (g [standard mean difference] = 0.25 [P < .001]; 95% CI, 0.10–0.40). Moderator analyses revealed that interventions that did not reward participants had a significantly greater effect on PA than interventions that did provide rewards (g = 1.30 vs 0.60, respectively, P ≤ .003). No other significant moderators were found. Conclusion: Our review offers initial insight into the long-term effects of specific goals on PA and psychological outcomes in insufficiently active adults. Further research that examines the PA and psychological effects of goal-setting interventions and investigates a wider range of goal types could develop a stronger evidence base to inform intervention for insufficiently active individuals.
The Associations Between Parental-Reported and Device-Based Measured Outdoor Play and Health Indicators of Physical, Cognitive, and Social–Emotional Development in Preschool-Aged Children
Authors: Davenport Cody , Kuzik Nicholas , Larouche Richard , Carson Valerie 
Published: April 2024

Purpose: Examine in preschool-aged children: (1) the associations between parental-reported and device-measured outdoor play (OP) and health indicators of physical, cognitive, and social–emotional development and (2) whether associations were independent of outdoor moderate- to vigorous-intensity physical activity (MVPA). Methods: This cross-sectional study included 107 participants. Children’s OP was measured via a parental questionnaire and the lux feature of accelerometers. Children’s growth, adiposity, and motor skills were assessed as physical development indicators. Visual–spatial working memory, response inhibition, and expressive language were assessed as cognitive development indicators. Sociability, prosocial behavior, internalizing, externalizing, and self-regulation were assessed as social–emotional development indicators. Regression models were conducted that adjusted for relevant covariates. Additional models further adjusted for outdoor MVPA. Results: Parental-reported total OP, OP in summer/fall months, and OP on weekdays were negatively associated (small effect sizes) with response inhibition and working memory. After adjusting for outdoor MVPA, these associations were no longer statistically significant. OP on weekdays was negatively associated with externalizing (B = −0.04; 95% confidence interval, −0.08 to −0.00; P = .03) after adjusting for outdoor MVPA. A similar pattern was observed for device-based measured total OP (B = −0.49; 95% confidence interval, −1.05 to 0.07; P = .09). Conclusions: Future research in preschool-aged children should take into account MVPA and contextual factors when examining the association between OP and health-related indicators.
In vitro
activity of cefoxitin, imipenem, meropenem, and ceftaroline in combination with vaborbactam against
Mycobacterium abscessus
Authors: Chen Liang , Shashkina Elena , Kurepina Natalia , Calado Nogueira de Moura Vinicius , Daley Charles L. , Kreiswirth Barry N. 
Published: April 2024

ABSTRACT

Mycobacterium abscessus
(MAB) infections pose a growing public health threat. Here, we assessed the
in vitro
activity of the boronic acid-based β-lactamase inhibitor, vaborbactam, with different β-lactams against 100 clinical MAB isolates. Enhanced activity was observed with meropenem and ceftaroline with vaborbactam (1- and >4-fold MIC
50
/
90
reduction). CRISPRi-mediated
bla
MAB
gene knockdown showed a fourfold MIC reduction to ceftaroline but not the other β-lactams. Our findings demonstrate vaborbactam’s potential in combination therapy against MAB infections.
CslA and GlxA from
Streptomyces lividans
form a functional cellulose synthase complex
Authors: Zhong Xiaobo , Nicolardi Simone , Ouyang Ruochen , Wuhrer Manfred , Du Chao , van Wezel Gilles , Vijgenboom Erik , Briegel Ariane , Claessen Dennis 
Published: April 2024

ABSTRACT

Filamentous growth of streptomycetes coincides with the synthesis and deposition of an uncharacterized protective glucan at hyphal tips. Synthesis of this glucan depends on the integral membrane protein CslA and the radical copper oxidase GlxA, which are part of a presumably large multiprotein complex operating at growing tips. Here, we show that CslA and GlxA interact by forming a protein complex that is sufficient to synthesize cellulose
in vitro
. Mass spectrometry analysis revealed that the purified complex produces cellulose chains with a degree of polymerization of at least 80 residues. Truncation analyses demonstrated that the removal of a significant extracellular segment of GlxA had no impact on complex formation, but significantly diminished activity of CslA. Altogether, our work demonstrates that CslA and GlxA form the active core of the cellulose synthase complex and provide molecular insights into a unique cellulose biosynthesis system that is conserved in streptomycetes.

IMPORTANCE

Cellulose stands out as the most abundant polysaccharide on Earth. While the synthesis of this polysaccharide has been extensively studied in plants and Gram-negative bacteria, the mechanisms in Gram-positive bacteria have remained largely unknown. Our research unveils a novel cellulose synthase complex formed by the interaction between the cellulose synthase-like protein CslA and the radical copper oxidase GlxA from
Streptomyces lividans
, a soil-dwelling Gram-positive bacterium. This discovery provides molecular insights into the distinctive cellulose biosynthesis machinery. Beyond expanding our understanding of cellulose biosynthesis, this study also opens avenues for exploring biotechnological applications and ecological roles of cellulose in Gram-positive bacteria, thereby contributing to the broader field of microbial cellulose biosynthesis and biofilm research.
Association between physical activity over a 10-year period and current insomnia symptoms, sleep duration and daytime sleepiness: a European population-based study
Authors: Bjornsdottir Erla , Thorarinsdottir Elin Helga , Lindberg Eva , Benediktsdottir Bryndis , Franklin Karl , Jarvis Debbie , Demoly Pascal , Perret Jennifer L , Garcia Aymerich Judith , Dorado-Arenas Sandra , Heinrich Joachim , Torén Kjell , Garcia Larsen Vanessa , Jögi Rain , Gislason Thorarinn , Janson Christer 
Published: April 2024

ObjectivesTo explore the relationship between physical activity over a 10-year period and current symptoms of insomnia, daytime sleepiness and estimated sleep duration in adults aged 39–67.DesignPopulation-based, multicentre cohort study.Setting21 centres in nine European countries.MethodsIncluded were 4339 participants in the third follow-up to the European Community Respiratory Health Survey (ECRHS III), who answered questions on physical activity at baseline (ECRHS II) and questions on physical activity, insomnia symptoms, sleep duration and daytime sleepiness at 10-year follow-up (ECRHS III). Participants who reported that they exercised with a frequency of at least two or more times a week, for 1 hour/week or more, were classified as being physically active. Changes in activity status were categorised into four groups: persistently non-active; became inactive; became active; and persistently active.Main outcome measuresInsomnia, sleep time and daytime sleepiness in relation to physical activity.ResultsAltogether, 37% of participants were persistently non-active, 25% were persistently active, 20% became inactive and 18% became active from baseline to follow-up. Participants who were persistently active were less likely to report difficulties initiating sleep (OR 0.60, 95% CI 0.45–0.78), a short sleep duration of ≤6 hours/night (OR 0.71, 95% CI 0.59–0.85) and a long sleep of ≥9 hours/night (OR 0.53, 95% CI 0.33–0.84) than persistently non-active subjects after adjusting for age, sex, body mass index, smoking history and study centre. Daytime sleepiness and difficulties maintaining sleep were not related to physical activity status.ConclusionPhysically active people have a lower risk of some insomnia symptoms and extreme sleep durations, both long and short.
Estimating the impact on patient safety of enabling the digital transfer of patients’ prescription information in the English NHS
Authors: Camacho Elizabeth M , Gavan Sean , Keers Richard Neil , Chuter Antony , Elliott Rachel Ann 
Published: April 2024

ObjectivesTo estimate the number and burden of medication errors associated with prescription information transfer within the National Health Service (NHS) in England and the impact of implementing an interoperable prescription information system (a single digital prescribing record shared across NHS settings) in reducing these errors.MethodsWe constructed a probabilistic mathematical model. We estimated the number of transition medication errors that would be undetected by standard medicines reconciliation, based on published literature, and scaled this up based on the annual number of hospital admissions. We used published literature to estimate the proportion of errors that lead to harm and applied this to the number of errors to estimate the associated burden (healthcare resource use and deaths). Finally, we used reported effect sizes for electronic prescription information sharing interventions to estimate the impact of implementing an interoperable prescription information system on number of errors and resulting harm.ResultsAnnually, around 1.8 million (95% credibility interval (CrI) 1.3 to 2.6 million) medication errors were estimated to occur at hospital transitions in England, affecting approximately 380 000 (95% CrI 260 397 to 539 876) patient episodes. Harm from these errors affects around 31 500 (95% CrI 22 407 to 42 906) patients, with 36 500 (95% CrI 25 093 to 52 019) additional bed days of inpatient care (costing around £17.8 million (95% CrI £12.4 to £24.9 million)) and >40 (95% CrI 9 to 146) deaths. Assuming the implementation of an interoperable prescription information system could reduce errors by 10% and 50%, there could be 180 000–913 000 fewer errors, 3000–15 800 fewer people who experience harm and 4–22 lives saved annually.ConclusionsAn interoperable prescription information system could provide major benefits for patient safety. Likely additional benefits include healthcare professional time saved, improved patient experience and care quality, quicker discharge and enhanced cross-organisational medicines optimisation. Our findings provide vital safety and economic evidence for the case to adopt interoperable prescription information systems.
Precision predictions for dark matter with DM@NLO in the MSSM
Authors: Harz Julia , Herrmann Björn , Klasen Michael , Kovařík Karol , Wiggering Luca Paolo 
Published: April 2024

AbstractWe present DM@NLO, a Fortran 77 based program with a C++ interface dedicated to precision calculations of dark matter (DM) (co)annihilation cross-sections and elastic dark matter-nucleon scattering amplitudes in the minimal supersymmetric (SUSY) Standard Model (MSSM) at next-to-leading order (NLO) in perturbative (SUSY) QCD. If the annihilating initial particles carry an electric or colour charge, the Sommerfeld enhanced cross section is included as well and can be matched to the NLO cross section. We review these calculations including technical details relevant for using the code. We illustrate their impact by applying DM@NLO to an example scenario in the constrained MSSM.
Gravitational memory effects of black bounces and a traversable wormhole
Authors: Hadi Hamed , Naderi Reza 
Published: April 2024

AbstractBlack bounces are spacetimes that can be interpreted as either black holes or wormholes depending on specific parameters. In this study, we examine the Simpson–Visser and Bardeen-type solutions as black bounces and investigate the gravitational wave in the background of these solutions. We then explore the displacement and velocity memory effects by analyzing the deviation of two neighboring geodesics and their derivatives influenced by the magnetic charge parameter a. This investigation aims to trace the magnetic charge in the gravitational memory effect. Additionally, we consider another family of traversable wormhole solutions obtained from non-exotic matter sources to trace the electric charge $$Q_{e}$$

Q
e

in the gravitational memory effect, which can be determined from the far field asymptotic. Furthermore, this research aims to explore the gravitational memory effect related to the variation in Bondi mass for the Simpson–Visser and Bardeen-type black bounces. The investigation will also be conducted on a traversable wormhole solution that does not require any exotic field. This study holds importance in not only identifying compact objects such as wormholes through gravitational memory effects but also in observing the charge $$Q_{e}$$

Q
e

, which offers a tangible manifestation of Wheeler’s idea of “electric charge without charge.”
Score-based Graph Learning for Urban Flow Prediction
Authors: Wang Pengyu , Luo Xuechen , Tai Wenxin , Zhang Kunpeng , Trajcevsky Goce , Zhou Fan 
Published: April 2024

Accurate urban flow prediction (UFP) is crucial for a range of smart city applications such as traffic management, urban planning, and risk assessment. To capture the intrinsic characteristics of urban flow, recent efforts have utilized spatial and temporal graph neural networks to deal with the complex dependence between the traffic in adjacent areas. However, existing graph neural network based approaches suffer from several critical drawbacks, including improper graph representation of urban traffic data, lack of semantic correlation modeling among graph nodes, and coarse-grained exploitation of external factors. To address these issues, we propose
DiffUFP
, a novel probabilistic graph-based framework for UFP. DiffUFP consists of two key designs: (1) a semantic region dynamic extraction method that effectively captures the underlying traffic network topology, and (2) a conditional denoising score-based adjacency matrix generator that takes spatial, temporal, and external factors into account when constructing the adjacency matrix rather than simply concatenation in existing studies. Extensive experiments conducted on real-world datasets demonstrate the superiority of DiffUFP over the state-of-the-art UFP models and the effect of the two specific modules.
Exploring Ferroptosis-Inducing Therapies for Cancer Treatment: Challenges and Opportunities
Authors: Lei Guang , Gan Boyi 
Published: April 2024

Abstract
Conventional cancer therapies typically aim to eliminate tumor cells by inducing cell death. The emergence of resistance to these standard treatments has spurred a shift in focus toward exploring alternative cell death pathways beyond apoptosis. Ferroptosis—an iron-dependent regulated cell death triggered by lipid peroxide accumulation—has gained prominence in cancer research in recent years. Ferroptosis-inducing therapies hold promise for overcoming resistance encountered with conventional treatments. However, challenges, including the lack of distinctive ferroptosis markers and the intricate role of ferroptosis within the tumor microenvironment, currently hinder the clinical translation of these therapies. This perspective article critically outlines these hurdles and highlights unexplored opportunities in ferroptosis research, aiming to refine its therapeutic utilization in combating cancer.
The Rigidity Connection: Matrix Stiffness and Its Impact on Cancer Progression
Authors: Yui Anna , Oudin Madeleine J. 
Published: April 2024

Abstract
The extracellular matrix (ECM) has always been studied in the context of the structural support it provides tissues. However, more recently, it has become clear that ECM proteins do more to regulate biological processes relevant to cancer progression: from activating complex signaling pathways to presenting soluble growth factors. In 2009, Ulrich and colleagues provided evidence that the physical properties of the ECM could also contribute to glioblastoma tumor cell proliferation and invasion using tunable hydrogels, emphasizing a role for tumor rigidity in central nervous system cancer progression. Here, we will discuss the results of this landmark article, as well as highlight other work that has shown the importance of tissue stiffness in glioblastoma and other tumor types in the tumor microenvironment. Finally, we will discuss how this research has led to the development of novel treatments for cancer that target tumor rigidity.
See related article by Ulrich and colleagues, Cancer Res 2009;69:4167–74
Personalized Cancer Vaccines Directed against Tumor Mutations: Building Evidence from Mice to Humans
Authors: Fritsch Edward F. , Ott Patrick A. 
Published: April 2024

Abstract
Personalized vaccines directed to tumor mutations have recently gained significant momentum. On the basis of the concept of stimulating T-cell responses against neoantigens encoded by a tumor's host of personal mutations, these vaccines utilize genome or exome sequencing, mutation calling, and epitope prediction followed by manufacturing of a customized vaccine for each patient. In their 2012 Cancer Research publication, Castle and colleagues provided evidence that vaccinating with long peptide vaccines encompassing neoantigens can generate robust immune responses and induce antitumor activity in a mouse B16F10 melanoma. This approach, harnessing the exquisite specificity of mutations to the tumor and thus providing an effective target for cancer vaccines, was subsequently shown to be safe and immunogenic in a series of small first in man trials in patients with melanoma. The field has accelerated and expanded substantially over the last 5 years, propelled by increasing evidence for vaccine-mediated clinical efficacy, leading to ongoing registrational trials using personalized RNA neoantigen vaccines in patients with melanoma and several other malignancies.
See related article by Castle and colleagues, Cancer Res 2012;72:1081–91
Cancer Builds a Noxious Partnership with Psychologic Stress
Authors: Magnon Claire 
Published: April 2024

Abstract
I was recently surprised to hear a medical doctor on a TV show refute the role of stress in cancer, assuming that “the whole population would have cancer if this was the case.” This statement illustrates a long and winding road since Hippocrates suggested the potential relationship between cancer and psychologic disturbances. The 20th and 21st centuries have finally witnessed the evidence of how physical or psychosocial stress situations contribute to the development and progression of cancer, and it is now assumed that psychologic stress does affect multiple aspects of cancer such as angiogenesis, immunologic escape, invasion, and metastasis. The 2010 publication by Sloan and colleagues in Cancer Research achieved a mechanistic step toward the understanding of how physical distress enhances metastasis through perturbation of the tumor immune system and paves the way for future cancer research in psychoneuroimmunology. This Landmark commentary places this publication in the historical context of science, discusses major advances in the field, and asks questions to be answered while drawing perspectives on the key role of the peripheral and central nervous systems in cancer.
See related article by Sloan and colleagues, Cancer Res 2010;70:7042–52
Living in Syn: T Cell Antigen Identification Based on Synapse Sequencing
Authors: Makani Venkata Krishna Kanth , Joglekar Alok V. 
Published: April 2024

AbstractThe pivotal role of T cell responses has been well studied in both protective and destructive scenarios. T cells recognize peptide epitopes presented on Human Leukocyte Antigens (HLA) through their surface T cell receptors (TCR). Advances in single-cell RNA sequencing have identified millions of TCRs, but only a minuscule fraction of them have known epitopes. Recently, cell-based T cell antigen discovery platforms have emerged onto the landscape. Here, Jin and colleagues, report a novel antigen discovery platform called Tsyn-seq that relies on sequencing TCR-peptide-HLA–induced synapses for genome-wide epitope screening.See related article by Jin et al., p. 530 (3).
CD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular Inflammation
Authors: Chen Junxiong , Ding Yingjun , Jiang Chao , Qu Rongmei , Wren Jonathan D. , Georgescu Constantin , Wang Xuejun , Reuter Darlene N. , Liu Beibei , Giles Cory B. , Mayr Christoph H. , Schiller Herbert B. , Dai Jingxing , Stipp Christopher S. , Subramaniyan Bharathiraja , Wang Jie , Zuo Houjuan , Huang Chao , Fung Kar-Ming , Rice Heather C. , Sonnenberg Arnoud , Wu David , Walters Matthew S. , Zhao You-Yang , Kanie Tomoharu , Hays Franklin A. , Papin James F. , Wang Dao Wen , Zhang Xin A. 
Published: April 2024

BACKGROUND:
Tetraspanin CD151 is highly expressed in endothelia and reinforces cell adhesion, but its role in vascular inflammation remains largely unknown.

METHODS:
In vitro molecular and cellular biological analyses on genetically modified endothelial cells, in vivo vascular biological analyses on genetically engineered mouse models, and in silico systems biology and bioinformatics analyses on CD151-related events.

RESULTS:

Endothelial ablation of
Cd151
leads to pulmonary and cardiac inflammation, severe sepsis, and perilous COVID-19, and endothelial CD151 becomes downregulated in inflammation. Mechanistically, CD151 restrains endothelial release of proinflammatory molecules for less leukocyte infiltration. At the subcellular level, CD151 determines the integrity of multivesicular bodies/lysosomes and confines the production of exosomes that carry cytokines such as ANGPT2 (angiopoietin-2) and proteases such as cathepsin-D. At the molecular level, CD151 docks VCP (valosin-containing protein)/p97, which controls protein quality via mediating deubiquitination for proteolytic degradation, onto endolysosomes to facilitate VCP/p97 function. At the endolysosome membrane, CD151 links VCP/p97 to (1) IFITM3 (interferon-induced transmembrane protein 3), which regulates multivesicular body functions, to restrain IFITM3-mediated exosomal sorting, and (2) V-ATPase, which dictates endolysosome pH, to support functional assembly of V-ATPase.

CONCLUSIONS:
Distinct from its canonical function in strengthening cell adhesion at cell surface, CD151 maintains endolysosome function by sustaining VCP/p97-mediated protein unfolding and turnover. By supporting protein quality control and protein degradation, CD151 prevents proteins from (1) buildup in endolysosomes and (2) discharge through exosomes, to limit vascular inflammation. Also, our study conceptualizes that balance between degradation and discharge of proteins in endothelial cells determines vascular information. Thus, the IFITM3/V-ATPase-tetraspanin-VCP/p97 complexes on endolysosome, as a protein quality control and inflammation-inhibitory machinery, could be beneficial for therapeutic intervention against vascular inflammation.