bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENERAPAN ARSITEKTUR PERMAKULTUR PADA POLA LANSEKAP TAMAN WISATA PERTANIAN HORTIKULTURA INTAN ABATANI DI MOJOKERTO
Authors: Sutrisno Intan Nuhita Ardia , Masruchin Febby Rahmatullah 
Published: March 2024

Di Kabupaten Mojokerto, sebagian besar wilayahnya merupakan lahan pertanian. Masyarakatnya mayoritas bekerja sebagai petani. Namun, hingga saat ini masih banyak ditemukan petani yang mengalami gagal panen. Hal tersebut dikarenakan, kurangya pengetahuan tentang budidaya yang benar serta pengobatan tanaman atas serangan hama, atau cara mengatasi karena cuaca yang tidak menentu. Oleh karenanya, perlu adanya suatu fasilitas untuk mengedukasi masyarakat tentang cara pertanian yang terintegrasi. Sesuai dengan RPJMD (Rencana Pembangunan Jangka Menengah Daerah) kabupaten Mojokerto, yang telah ditetapkan suatu prioritas pengembangan sektor pertanian dan peternakan yang dikemas dalam suatu sektor pariwisata. Hal tersebut dapat diterapkan pada salah satu tempat wisata yang ada di Kabupaten Mojokerto, yaitu “Taman Wisata Intan Abatani”, taman wisata tersebut merupakan tempat wisata yang mengutamakan fungsi edukasi pertanian yang terintegrasi. Perlu tindakan untuk mengembangkannya guna memberikan fasilitas yang memadahi sebagai tempat edukasi pertanian terintegrasi. Lansekap dengan tatanan pola yang tepat dapat membuat suatu produksi pertanian berintegrasi dengan baik, sehingga akan menjadikan suatu pertanian yang berkelanjutan. Penerapan konsep permakultur akan membuat suatu desain untuk lingkungan dengan menerapkan pengembangan arsitektur yang berkelanjutan serta sistem pertanian swadaya berdasarkan ekosistem alam. Metode yang digunakan melalui literatur, survei, pengumpulan data eksisting, dan wawancara. Yang menghasilkan suatu desain tatanan pada pola lansekap wisata pertanian.
Program Kreativitas Santri dalam Pengelolaan Sampah Plastik di PP. Zainul Hasan Genggong Probolinggo
Authors: Paramita Sari  , Windi Indria Rini  , Ratna Ariesta Dwi Andriani  , Uliyatul Laili  , Nur Sophia Matin  
Published: March 2024

Plastik adalah penyumbang limbah terbesar yang menyebabkan kerusakan lingkungan. Untuk menguraikannya, diperlukan antara lima ratus hingga seribu tahun. Ketergantungan masyarakat terhadap plastik menjadi bahaya bagi lingkungan, baik jangka pendek, menengah, maupun panjang. Permasalahan plastik harus dikerjakan secara lintas sektoral, termasuk pesantren sebagai lembaga Pendidikan berbasis keagamaan. Potensi pesantren yang besar dalam menangani permasalahan plastik mendorong FK UNUSA untuk berkolaborasi dengan salah satu pesantren, yakni Pondok Pesantren Zainul Hasan Genggong, Probolinggo. Dosen dan mahasiswa FK UNUSA mengadakan penyuluhan terkait pengelolaan sampah plastik bagi para santri pondok, khususnya santri kelas X dan XI. Dalam pelaksanaan kegiatan ini dilakukan pretest sebelum materi dan posttest setelah materi. Dari hasil yang didapat, dilakukan uji paired sample T test, secara statistik diperoleh hasil terdapat perbedaan yang signifikan. Dapat diambil kesimpulan bahwa penyuluhan yang diberikan memberi pengaruh yang bermakna. Diperlukan pengabdian dan pendampingan lebih lanjut kepada para santri, khususnya terkait upaya berkelanjutan yang bisa dilakukan dalam mengelola sampah plastik di pondok pesantren.
Upaya Mengurangi Keluhan Sistem Muskuloskeletal pada Pekerja Percetakan
Authors: Ratna Ayu Ratriwardhani  , Muslikha Nourma Rhomadhoni  , Octavianus Hutapea  , Merry Sunaryo  , Rivani Risha Kurniati  
Published: March 2024

Potensi bahaya industri percetakan terdiri dari bahaya kesehatan dan bahaya keselamatan. Contoh bahaya keselamatan seperti terjadinya kebakaran, kemudian contoh bahaya kesehatan antara lain bahaya akibat paparan bahan kimia dan bahaya akibat posisi kerja yang salah atau desain stasiun kerja yang kurang ergonomis. Dari beberapa permasalahan tersebut, maka melakukan sosialisasi ergonomi dianggap sangat penting dan efektif. Pada aktivitas kerja seringkali menimbulkan nyeri pada tulang belakang dan pinggang para pekerja, hal ini diketahui dari hasil wawancara kepada para pekerja disana. Kegiatan ini mempunyai tujuan untuk memberikan pengetahuan kepada para pekerja percetakan tentang ergonomi sehingga terhindar dari risiko penyakit MSDs. Upaya mengurangi keluhan sistem muskuloskeletal dilakukan dengan melakukan training kepada para pekerja yang meliputi memberikan pengetahuan megenai MSDs dan Ergonomi, kemudian memberikan solusi bagaimana cara mencegah risiko ergonomi. Sebelumnya diukur dahulu bagaimana tingkat pengetahuan para pekerja tentang hal-hal tersebut melalui kuesioner. Kemudian setelah dilakukan training, kegiatan dilanjutkan dengan menganalisis tingkat pengetahuan para pekerja melalui post test. Kemudian 1 bulan setelah sosialisasi dilakukan akan diadakan pengambilan data dari para pekerja untuk melihat apakah keluhan-keluhan yang berkaitan dengan sistem muskuloskeketal masih dirasakan atau tidak. Dari 30 orang pekerja percetakan yang ikut dalam kegiatan ini, sebagian besar para pekerja pernah mengalami penyakit akibat kerja berupa cidera pada tulang belakang (18 orang) dan cidera pada pinggang (5 orang). Hasil identifikasi sebanyak 4 responden (17,39%) menyatakan sudah tidak merasakan Penyakit Akibat Kerja setelah 1 bulan Kegiatan Pengabdian kepada Masyarakat dilakukan. Data ini diambil dari 23 responden yang sebelumnya menjawab pernah mengalami Penyakit Akibat Kerja. Berdasarkan hasil yang diperoleh dapat diketahui bahwa kegiatan pengabdian berhasil, karena telah meningkatkan pengetahuan pekerja tentang Pencegahan Risiko Ergonomi dan mengurangi Penyakit Akibat Kerja yang sebelumnya dialami oleh para pekerja.
Pendampingan Pengolahan Dan Manajemen Bank Sampah Desa Ploso Kerep Kecamatan Sumobito
Authors: M. Imsin  , Dina Eka Shofiana  
Published: March 2024

Dalam Hal ini P2KTD Unipdu memperoleh 2 Bidang Fokus yaitu Pertama Layanan P2KTD bidang kewirausahaan dan pengembangan ekonomi lokal disesuaikan dengan kebutuhan dan karakteristik desa dalam pendukung pengembangan Produk Unggulan Desa (Prudes) dan Produk Unggulan Kawasan Perdesaan (prukades) serta BUM Desa atau BUM Desa Bersama. Bentuk penyedia layanan teknis pengembangan ekonomi lokal dan kewirausahaan dapat berupa analisis dan identifikasi sumberdaya lokal, analisis keberlanjutan usaha, pengembangan SDM dan kelembagaan, pengembangan produksi, dan mata rantai usaha (market chain) yang dikelola secara mandiri, serta pengelolaan keuangan mikro. Wirausahawan Sosial adalah individu yang memberikan solusi inovatif untuk menyelesaikan permasalahan sosial di masyarakat Desa dengan menawarkan ide kreatif berorientasi bisnis. Misalnya: pengelolaan sampah, pengelolaan air bersih, pemanfaatan biogas, dan produk daur ulang, dan desa wisata. Bentuk kegiatan layanan teknis Pengembangan Sumber Daya Manusia dapat berupa pelatihan dan bimbingan untuk mendorong kemandirian Desa dalam memberikan pelayanan sosial dasar yang berkualitas (seperti: Posyandu Mandiri, Pengelolaan PAUD), serta menumbuhkan kewirausahaan sosial di desa Manajemen pengelolaan bank sampah menjadi utama.
Identification and quantification of flavonoids and hydroxycinnamic acids in yellow wood anemone (<i>Anemone ranunculoides</i> L.) by UHPLC-DAD-HESI/MS analysis
Authors: Luferov A. N. , Bobkova N. V. , Bokov D. O. , Rodin M. N. , Sergunova E. V. , Kovaleva T. Yu. , Rendyuk T. D. , Strelyaeva A. V. , Antsyshkina A. M. , Prostodusheva T. V. , Zaichikova S. G. , Baeva V. M. , Perova I. B. , Eller K. I. , Bessonov V. V. 
Published: March 2024

Introduction. Yellow wood anemone (Anemone ranunculoides L.) is a herbaceous perennial. This plant grows in the European parts of Russia, Ciscaucasia, Siberia, Central Europe and other regions. It has many different pharmacological activities: immunomodulatory, sedative, anti-inflammatory, antitoxic, diuretic, antibacterial, antioxidant, antitumor and antirheumatic activity. These various effects are due to their biologically active compounds, which include ephemeroids, protoanemonin, saponins, tannins, resins, ascorbic acid, ranunculin, oils lipids and triterpene glycosides. As to phenolic compounds, currently there is no sufficient information on flavonoids and hydroxycinnamic acids (HCAs) profiles in different species of genus Anemone. Because these groups of compounds are quite specific for yellow wood anemone, their detailed study seems to be relevant.Aim. The objective of this research is to identify and quantify flavonoids, HCAs, and their conjugates in Yellow wood anemone leaves, flowers and rhizomes with roots.Materials and methods. The identification was carried out by using ultra-high-performance liquid chromatography with diode array and electrospray ionization-mass spectrometric detection (UHPLC–DAD–ESI-MS) with quantification of individual compounds by external calibration method.Results and discussion. Among the 47 compounds, 30 flavonoids and 17 derivatives of HCAs were detected. Quercetin glycosides were found to be the major flavonoids in aerial parts whereas chalcone glycosides – in underground parts. The major HCA in rhizomes with roots was feruloyltartaric acid (1.18 mg/g) whereas chlorogenic acid was predominant in leaves and flowers (8.68 mg/g and 2.62 mg/g accordingly). The total content of phenolic compounds was estimated at 60 mg/g on a dry weight basis.Conclusion. As a result of the research a detailed profile of flavonoids and HCAs acids of anemon was described. The data obtained can serve to identify this species in the standardization of medicinal plant materials and taxonomic studies.
Non-medical Use of Prescription Psychostimulants and Academic Performance in Medical Students
Authors: Sümbül Şekerci Betül , Bektay Muhammed Yunus , Bildik Özlem 
Published: March 2024

Objective: It is well-known that healthy medical students use psychostimulants to improve their cognitive functions and reduce their need for sleep. The main motivation behind this cognitive enhancement is to increase academic performance. However, the literature is not clear enough to support this situation.
Methods: This cross-sectional study was conducted with an online survey and 585 students participated. The grade point average number was used to assess the student' academic performance. Additionally, the scale based on self-evaluations was used to assess levels of pharmaceutical knowledge, study performance, academic success, academic anxiety, and study performance.
Results: Out of 585 healthy students, 40 (7.3%) admitted to using psychostimulants to enhance their academic performance. However, there was no significant difference in grade point average scores and perceived academic success levels between users and non-users. Nonetheless, most of the users reported that they benefited from taking psychostimulant drugs. Risk factors for non-medical use of prescription psychostimulants included high levels of pharmacology knowledge, smoking, and poor academic performance.
Conclusion: Although non-medical use of prescription psychostimulants did not appear to affect academic performance significantly, most students reported positive subjective experiences, which could have a motivational effect. Therefore, it is crucial to investigate the benefits and side effects of psychostimulants in healthy young individuals in more detail and to provide them with up-to-date information on this issue.
The Effect of Theory-Based Care on Breastfeeding Self-Efficacy, Anxiety and Breast Milk Release
Authors: Gürel Reyyan , Şentürk Erenel Ayten 
Published: March 2024

Objective: The effect of nursing care provided according to Dennis’ breastfeeding self-efficacy theory on breastfeeding self-efficacy, anxiety, and breast milk secretion was evaluated.
Methods: In this quasi-experimental study, 60 mothers in the first week postpartum were examined. The mothers and their supporters in the Dennis Theory-Based Nursing Care group were trained. Before the training, mothers were given the personal information form and the breastfeeding diary form to be filled out for 15 days. The perception of breastfeeding self-efficacy of mothers was evaluated using the “Postpartum Breastfeeding Self-Efficacy Scale”. Their anxiety was determined using the “State Anxiety Scale”, and breast milk release was assessed using the “Daily Form for Baby’s Adequate Nutrition”. The parameters were measured on the first day and 15 days after the training. Routine hospital standard nursing care was provided to the mothers in the control group.
Results: The number of formulas given by mothers in the Dennis Theory-Based Nursing Care group to their babies was significantly lower than the number of formulas given by the mothers in the control group (Z=–0.90, p
A Follow-Up Study of Children Diagnosed with Delayed Speech and Language
Authors: Yurdakul Çınar Fatma , Çiprut Ayça 
Published: March 2024

Objective: The aim of our study was to examine the current health status of children with normal peripheral hearing who were referred to the audiology clinic with complaints of speech and language delay in early childhood.
Methods: The data of a retrospective file review in which the information of 105 children with normal hearing ages 12-60 months referred to the Audiology Clinic with complaints of speech and language delay were used in the study. After the initial diagnosis of delayed speech and language (approximately two years), their medical condition was assessed through semi-structured telephone interviews. The obtained data are presented with descriptive statistics.
Results: Out of 105 children, 54 (51.4%) were diagnosed with other additional diagnoses including; autism spectrum disorder:21 (20%), general developmental delay: 13 (12.3%), attention deficit and hyperactivity disorder: 9 (8.5%), epilepsy: 4 (3.8%).7 (6.6%) of children followed from endocrine, neurology, genetics, cardiology, nephrology and ophthalmology departments. 51 children (48.57%) have achieved the average level of speech and language development with interventions such as speech and language therapy and/or social support in the following period, and they do not currently have any medical follow-up.
Conclusion: The results indicated that cases where children who apply with the complaint of speech and language delay may have additional diagnoses in the future, or they can achieve the average level of speech and language development with specialist interventions. Long-term follow-up of this delay is important in terms of providing effective communication skills and the probability of being a diagnostic marker.
A DIMENSÃO CRÍTICA DO VESTIR
Authors: Oliveira Renata 
Published: March 2024

O presente artigo expõe um estudo sobre a transformação do ato de vestir emgesto crí­tico. As obras de Flávio de Carvalho, Hélio Oiticica e Laura Lima exemplificam aproblematização. Em alguns momentos de suas trajetórias, usam o vestir para mediar í relação entre o sujeito e o mundo. Eles viabilizam e expandem um olhar crí­tico para asociedade e o indiví­duo inserido nela, através do corpo, da roupa, da cultura, da arquitetura eda coletividade, dentre outros temas.PALAVRAS-CHAVE: Indiví­duo; Gesto Crí­tico; Arte; Vestir;
Mendelian randomization of chronic hepatitis B and cardiovascular disease
Authors: Wu Dongjie , Xiong Feiyang , Ran Qingzhi , Liu Jing , Wu Qingjuan , Wang Liang , Lv Wenliang 
Published: March 2024

BackgroundEvidence from observational studies suggests that chronic hepatitis B (CHB) is associated with cardiovascular disease (CVD). However, results have been inconsistent and causality remains to be established. We utilized two-sample Mendelian randomization (MR) to investigate potential causal associations between CHB and CVD, including atherosclerosis, coronary heart disease, hypertension, and ischemic stroke.MethodsThe analysis was conducted through genome-wide association studies (GWAS), considering chronic hepatitis B as the exposure and cardiovascular disease as the endpoint. The primary method for evaluating causality in this analysis was the inverse-variance weighted (IVW) technique. Additionally, we employed the weighted median, MR-Egger regression, weighted mode, and simple mode methods for supplementary analyses. Finally, heterogeneity tests, sensitivity analyses, and multiple effects analyses were conducted.ResultsIn a random-effects IVW analysis, we found that genetic susceptibility to chronic hepatitis B was associated with an increased risk of atherosclerosis [OR = 1.048, 95% CI (1.022–1.075), P = 3.08E-04], as well as an increased risk of coronary heart disease [OR = 1.039, 95% CI (1.006–1.072), P = 0.020]. However, it was found to be inversely correlated with ischemic stroke risk [OR = 0.972, 95% CI (0.957–0.988), P = 4.13E-04]. There was no evidence that chronic hepatitis B was associated with hypertension [OR = 1.021, 95% CI (0.994–1.049), P = 0.121].ConclusionOur research indicates that chronic hepatitis B has a correlation with an elevated risk of developing atherosclerosis and coronary heart disease, while it is associated with a decreased risk of experiencing an ischemic stroke.
Preoperative C-reactive protein/albumin ratio and mortality of off-pump coronary artery bypass graft
Authors: Oh Ah Ran , Kwon Ji-Hye , Park Jungchan , Min Jeong-Jin , Lee Jong-Hwan , Yoo Seung Yeon , Lee Dong Jae , Kim Wooksung , Cho Hyun Sung , Kim Chung Su , Lee Sangmin Maria 
Published: March 2024

BackgroundWe sought to investigate the prognostic value of preoperative C-reactive protein (CRP)-to-albumin ratio (CAR) for the prediction of mortality in patients undergoing off-pump coronary artery bypass grafting (OPCAB).MethodsFrom January 2010 to August 2016, adult patients undergoing OPCAB were analyzed retrospectively. In a total of 2,082 patients, preoperative inflammatory markers including CAR, CRP, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio were recorded. Receiver operating characteristic (ROC) curves were used to determine the optimal threshold and compare the predictive values of the markers. The patients were divided into two groups according to the cut-off value of CAR, and then the outcomes were compared. The primary end point was 1-year mortality.ResultsDuring the 1-year follow-up period, 25 patients (1.2%) died after OPCAB. The area under the curve of CAR for 1-year mortality was 0.767, which was significantly higher than other inflammatory markers. According to the calculated cut-off value of 1.326, the patients were divided into two groups: 1,580 (75.9%) patients were placed in the low CAR group vs. 502 (24.1%) patients in the high CAR group. After adjustment with inverse probability weighting, high CAR was significantly associated with increased risk of 1-year mortality after OPCAB (Hazard ratio, 5.01; 95% Confidence interval, 2.01–12.50; p &lt; 0.001).ConclusionsIn this study, we demonstrated that preoperative CAR was associated with 1-year mortality following OPCAB. Compared to previous inflammatory markers, CAR may offer superior predictive power for mortality in patients undergoing OPCAB. For validation of our findings, further prospective studies are needed.
The occurrence of immune-related adverse events is an independent risk factor both for serum HBsAg increase and HBV reactivation in HBsAg-positive cancer patients receiving PD-1 inhibitor combinational therapy
Authors: Zeng Yingfu , Huang Jiwei , Pang Jiahui , Pan Shufang , Wu Yuankai , Jie Yusheng , Li Xinhua , Chong Yutian 
Published: March 2024

BackgroundPrevious studies have suggested the potential of PD-1/PD-L1 inhibitors in the treatment of chronic HBV infection. However, since phase III clinical trials have not yet been announced, additional clinical insights may be obtained by observing changes in serum hepatitis B surface antigen (HBsAg) and HBV-DNA levels in cancer patients undergoing PD-1 inhibitor therapy.ObjectiveTo explore the effects of PD-1 inhibitor combinational therapy on serum HBsAg and HBV-DNA levels, investigate the incidence of HBsAg loss, HBV reactivation (HBVr), and immune-related adverse events (irAEs), and identify the risk factors associated with significant HBsAg fluctuations and HBVr. MethodsA retrospective study including 1195 HBsAg-positive cancer patients who received PD-1 inhibitors between July 2019 and June 2023 was conducted, and 180 patients were enrolled in this study. Serum HBsAg levels before and after PD-1 inhibitor administration were compared across different subgroups. The Pearson χ2 or Fisher exact test was performed to investigate the relationships between categorical variables. Univariable and multivariable analysis were performed to identify the risk factors associated with significant HBsAg fluctuations and HBVr. ResultsWith the concurrent use of antiviral agents, serum HBsAg levels decreased (Z=-3.966, P &lt; 0.0001) in 129 patients and increased (t=-2.047, P=0.043) in 51 patients. Additionally, 7 patients (3.89%) achieved serum HBsAg loss. Virus replication was suppressed in most of the enrolled patients. When divided patients into different subgroups, significant HBsAg decreases after PD-1 inhibitor administration were discovered in lower baseline HBsAg group (Z=-2.277, P=0.023), HBeAg-seronegative group (Z=-2.200, P=0.028), non-irAEs occurrence group (Z=-2.007, P=0.045) and liver cancer group (Z=-1.987, P=0.047). Of note, 11 patients and 36 patients experienced HBVr (6.11%) and irAEs (20%), respectively, which could lead to discontinuation or delayed use of PD-1 inhibitors. After multivariable analysis, HBeAg-seropositive (OR, 7.236 [95% CI, 1.757-29.793], P=0.01) and the occurrence of irAEs (OR, 4.077 [95% CI, 1.252-13.273], P=0.02) were identified as the independent risk factors for significant HBsAg increase, the occurrence of irAEs (OR, 5.560 [95% CI, 1.252-13.273], P=0.01) was identified as the only independent risk factor for HBVr. ConclusionPD-1 inhibitors combined with nucleos(t)ide analogues (NAs) may exert therapeutic potential for chronic HBV infection in cancer patients. However, attention also should be paid to the risk of significant elevation in HBsAg levels, HBVr, and irAEs associated with PD-1 inhibitor combinational therapy.
Comprehensive analysis of fibroblast activation protein expression across 23 tumor indications: insights for biomarker development in cancer immunotherapies
Authors: Dziadek Sebastian , Kraxner Anton , Cheng Wei-Yi , Ou Yang Tai-Hsien , Flores Mike , Theiss Noah , Tsao Tsu-Shuen , Andersson Emilia , Harring Suzana Vega , Bröske Ann-Marie E. , Ceppi Maurizio , Teichgräber Volker , Charo Jehad 
Published: March 2024

IntroductionFibroblast activation protein (FAP) is predominantly upregulated in various tumor microenvironments and scarcely expressed in normal tissues.MethodsWe analyzed FAP across 1216 tissue samples covering 23 tumor types and 70 subtypes.ResultsElevated FAP levels were notable in breast, pancreatic, esophageal, and lung cancers. Using immunohistochemistry and RNAseq, a correlation between FAP gene and protein expression was found. Evaluating FAP’s clinical significance, we assessed 29 cohorts from 12 clinical trials, including both mono and combination therapies with the PD-L1 inhibitor atezolizumab and chemotherapy. A trend links higher FAP expression to poorer prognosis, particularly in RCC, across both treatment arms. However, four cohorts showed improved survival with high FAP, while in four others, FAP had no apparent survival impact.ConclusionsOur results emphasize FAP’s multifaceted role in therapy response, suggesting its potential as a cancer immunotherapy biomarker.