bluuebunny/crossref_metadata_2025_split huggingface dataset:
OMI-based emission source classification in East China and its spatial redistribution in view of pollution control measures
Authors: Zara Marina , van der A Ronald , Ding Jieying , Stavrakou Trissevgeni , Boersma Folkert 
Published: February 2024

AbstractThis study aims to generate a satellite-based qualitative emission source characterization for the heavily polluted eastern part of China in the 2010–2016 time period. The applied source identification technique relies on satellite-based NOx and SO2 emission estimates by OMI, their SO2:NOx ratio, and the MIX anthropogenic emission inventory to distinguish emissions from different emission categories (urban, industrial, natural) and characterize the dominant source per 0.25° × 0.25° grid cell in East China. Overall, we find good agreement between the satellite- and emission inventory–based spatiotemporal distribution and characterization of the dominant emission sources in East China in 2010–2016. In 2010, the satellite measurements suggest an emission distribution less dominated by industrial areas, a somewhat larger role for urban/transportation areas and agricultural activities, and more natural emissions in the southern part compared to the bottom-up emission categorization. In 2016, more than half of the classified emission categories over East China have remained the same. At the same time, there is a notable increase of agricultural lands and decrease of areas dominated by industry/transportation in 2016, suggestive of an overall decrease in heavy air pollution in East China over the course of 7 years. This is likely attributed to the sustained efforts of the Chinese government to drastically improve the air quality, especially since 2013 when the National Air Pollution Prevention and Control Action Plan was enacted. However, signs of urban expansion (urbanization) and rural–urban migration (“Go West” motion) stemmed from China’s rapid economic growth and labour demand are evident; escalating industrialization (even with cleaner means) and the urban population growth in East China resulted in stronger emissions from sources representing consumption and transportation which are strongly related to NO2 and PM10 pollution (rather than SO2) and are directly influenced by the population size. This resulted to a shift of the emissions from the east mainly to the north and northwest of East China. Overall, although the effectiveness of the Chinese environmental control policies has been successful, the air pollution problem remains an important concern.
Clinical outcomes of traumatic globe rupture in corneal graft patients
Authors: Figueiredo Francisco , Sandhu Jas , Shaw Michael 
Published: February 2024

Abstract
Purpose
This study reports the mechanisms, complications and graft survival following sight-threatening traumatic globe rupture in patients having previously undergone corneal transplantation in the same eye.

Methods
A retrospective, observational, single-center consecutive cohort study at the Royal Victoria Infirmary, Newcastle upon Tyne, UK over a 20-year period. Medical records and Newcastle Corneal Transplantation Service electronic database (eNCTS) review was undertaken of all consecutive patients who underwent corneal transplantation with a history of traumatic globe rupture.
Main outcome measures include mechanism of injury, final best-corrected distance visual acuity (BCDVA), graft survival and complications.

Results
A total of 921 keratoplasties were undertaken between 1997 and 2017 with 24 (3.0%) patients identified with a history of traumatic globe rupture.
A bimodal relationship of age and mechanism of trauma was observed. The mean age (SD) of individuals reporting cause as a fall was 71.5 (14.8) years, and 45.3 (20.8) years (P < 0.05) amongst individuals reporting accidental trauma or assault.
The pre- and post-trauma mean (SD) LogMAR BCDVA was 0.6 (0.9) and 1.7 (1.0), respectively (P = 0.001). The overall graft-failure rate was 60.9% (11 grafts) during a mean (SD) follow-up period of 3.5 (4.1) years. Globe rupture with lens damage was associated with poorer final BCDVA (P < 0.05).

Conclusions
This study represents the first published series from England for this type of patient cohort. Overall visual outcomes were poor with a bimodal relationship of age and mechanism of trauma. Worse prognostic factors included lens and posterior segment complications. Re-grafting in these select group of patients may prove valuable.
Improvement of the photoelectrical properties of chemical bath-deposited Sb2S3 thin films with low copper doping
Authors: Salinas-Beltrán Susana , Gaitán-Arevalo Juniet R. , González Luis A. 
Published: February 2024

AbstractThe chemical bath deposition method was used to prepare Cu-doped Sb2S3 thin films from complexes of Cu and Sb with triethanolamine. The as-deposited films with orange coloration had good adherence to the substrate. After an annealing treatment at 300 °C for 30 min in an Ar atmosphere, the resulting films acquired a brown color and exhibited the orthorhombic phase of Sb2S3 with the preferential growth of [hk0] grains. The Sb2S3 films were formed by rod-shaped nanoparticles, while the insertion of Cu ions in Sb2S3 promoted the formation of ribbon-like structures. The analysis of optical properties indicated the narrowing of bandgap energy from 1.9 to 1.8 eV due to the presence of Cu ions. In addition, the photoconductivity of the films increased from 8.3 × 10–6 to 30.5 × 10–6 Ω−1cm−1, while the photosensitivity factor was enhanced by more than 3 times. The performance of photovoltaic devices based on CdS/Sb2S3 and CdS/Cu:Sb2S3 heterojunctions were investigated. Compared with the device using a Sb2S3 layer, the one using a Cu-doped Sb2S3 layer exhibited an increase in open circuit voltage from 118.2 to 205 mV, short circuit current density from 0.14 to 0.34 mA/cm2 and conversion efficiency from 0.02 to 0.12%. The best performance was obtained by a photovoltaic device with a 500 nm Cu-doped Sb2S3 layer reaching an open circuit voltage of 226 mV, a short circuit current density of 0.94 mA/cm2 and conversion efficiency of 0.32%.
Region-Specific Variation in the Electrophysiological Responses of Spodoptera frugiperda (Lepidoptera: Noctuidae) to Synthetic Sex Pheromone Compounds
Authors: Akinbuluma Mobolade D. , van Schaijk Renée A. H. , Roessingh Peter , Groot Astrid T. 
Published: February 2024

AbstractThe fall armyworm, Spodoptera frugiperda (J.E. Smith), is a global pest that feeds on  > 350 plant species and causes major yield loses. Variation in the responses of S. frugiperda males to female sex pheromone compounds affects the detection, monitoring and management of the pest. We determined geographic variation in the responses of S. frugiperda males to four different doses of synthetic sex pheromone compounds using a gas chromatography-electroantennogram detector (GC-EAD). Furthermore, we disentangled regional populations into C- and R- mitotypes via molecular analysis of the cytochrome oxidase I gene, and measured their responses to the compounds. When comparing responses of males from Florida, Benin, Nigeria and Kenya, we found some regional differences in the responses of S. frugiperda males to the major compound, Z9-14:OAc and minor component Z9-12:OAc. However, we found no differences in male responses between the different African countries. All males showed significantly higher antennal responses to Z7-12:OAc than to E7-12:OAc. When comparing the mitotypes, we found that Florida R-type males showed higher responses to Z9-14:OAc, Z7-12:OAc and Z9-12:OAc than Benin R-type males, while C-type males from both regions responded equally to Z7-12:OAc. In addition, Florida R-type males showed higher responses to E7-12:OAc than Florida C-type males. Our study thus shows some differential physiological responses of S. frugiperda males towards the known sex pheromone compounds, including E7-12:OAc, but mostly in the different mitotypes. How these differences translate to field trap catches remains to be determined.
The pharmaco-epigenetics of hypertension: a focus on microRNA
Authors: Yaacoub Serge , Boudaka Ammar , AlKhatib Ali , Pintus Gianfranco , Sahebkar Amirhossein , Kobeissy Firas , Eid Ali H. 
Published: February 2024

AbstractHypertension is a major harbinger of cardiovascular morbidity and mortality. It predisposes to higher rates of myocardial infarction, chronic kidney failure, stroke, and heart failure than most other risk factors. By 2025, the prevalence of hypertension is projected to reach 1.5 billion people. The pathophysiology of this disease is multifaceted, as it involves nitric oxide and endothelin dysregulation, reactive oxygen species, vascular smooth muscle proliferation, and vessel wall calcification, among others. With the advent of new biomolecular techniques, various studies have elucidated a gaping hole in the etiology and mechanisms of hypertension. Indeed, epigenetics, DNA methylation, histone modification, and microRNA-mediated translational silencing appear to play crucial roles in altering the molecular phenotype into a hypertensive profile. Here, we critically review the experimentally determined associations between microRNA (miRNA) molecules and hypertension pharmacotherapy. Particular attention is given to the epigenetic mechanisms underlying the physiological responses to antihypertensive drugs like candesartan, and other relevant drugs like clopidogrel, aspirin, and statins among others. Furthermore, how miRNA affects the pharmaco-epigenetics of hypertension is especially highlighted.
The two faces of hierarchy: CEO power and TMT learning diversity in technology venture innovation
Authors: Wesemann Henrik , Sirén Charlotta , He Vivianna Fang , Grichnik Dietmar , Wincent Joakim 
Published: February 2024

Abstract
The relationship between top management team (TMT) members’ learning behavior and the innovation strategy of technology ventures remains unclear, especially when complicated by social hierarchies within the team. We draw on organizational learning theory to theorize that diversity in TMT members’ learning behavior has both positive and negative latent effects that produce an inverted U-shaped relationship between TMT learning diversity and a firm’s radical innovation strategy. Building on the social hierarchy literature, we also suggest that CEO power moderates this relationship by altering the latent forces: structurally powerful CEOs neutralize the benefits of TMT learning diversity, turning the link between learning diversity and radical innovation strategy predominantly negative, whereas prestigiously powerful CEOs neutralize the costs of TMT learning diversity, turning its relationship with the firm’s radical innovation strategy predominantly positive. Longitudinal, multi-source data from 77 TMTs support our model. The findings contribute to the research on learning and social hierarchies by illustrating how hierarchies rooted in different sources of power have different effects on the relationship between TMT learning diversity and innovation strategy.
Measuring science and innovation linkage using text mining of research papers and patent information
Authors: Motohashi Kazuyuki , Koshiba Hitoshi , Ikeuchi Kenta 
Published: February 2024

AbstractIn this study, the text information of academic papers published by Japanese authors (about 1.7 million papers) and patents filed with the Japan Patent Office (about 12.3 million patents) since 1991 are used for analyzing the inter-relationship between science and technology. Specifically, a distributed representation vector using the title and abstract of each document is created, then neighboring documents to each are identified using the cosine similarity. A time trend and sector specific linkages within science and technology are identified by using the count of neighbor patents (papers) for each paper (patent). It is found that the science intensity of inventions (the number of neighbor papers for patents) increases over time, particularly for university/PRI patents and university–industry collaboration patents over the 30 years studied. As for university/PRI patents, the institutional reforms for the science sector (government laboratory incorporation in 2001 and national university incorporation in 2004) contributed to the interactions between science and technology. In contrast, the technology intensity of science (the number of neighbor patents by paper) decreases over time. It is also found that the technology intensity of life science papers is rather low, although they have a significant impact on subsequent patents. However, there are some scientific fields which are affected by technological developments, so that the state of science and innovation interactions is heterogeneous across the fields.
Leuconostoc mesenteroides and Liquorilactobacillus mali strains, isolated from Algerian food products, are producers of the postbiotic compounds dextran, oligosaccharides and mannitol
Authors: Zarour Kenza , Zeid Ahmed Fouad , Mohedano Mari Luz , Prieto Alicia , Kihal Mebrouk , López Paloma 
Published: February 2024

AbstractSix lactic acid bacteria (LAB) isolated from Algerian sheep’s milk, traditional butter, date palm sap and barley, which produce dextran, mannitol, oligosaccharides and vitamin B2 have been characterized. They were identified as Leuconostoc mesenteroides (A4X, Z36P, B12 and O9) and Liquorilactobacillus mali (BR201 and FR123). Their exopolysaccharides synthesized from sucrose by dextransucrase (Dsr) were characterized as dextrans with (1,6)-d-glucopyranose units in the main backbone and branched at positions O-4, O-2 and/or O-3, with d-glucopyranose units in the side chain. A4X was the best dextran producer (4.5 g/L), while the other strains synthesized 2.1–2.7 g/L. Zymograms revealed that L. mali strains have a single Dsr with a molecular weight (Mw) of ~ 145 kDa, while the Lc. mesenteroides possess one or two enzymes with 170–211 kDa Mw. As far as we know, this is the first detection of L. mali Dsr. Analysis of metabolic fluxes from sucrose revealed that the six LAB produced mannitol (~ 12 g/L). The co-addition of maltose–sucrose resulted in the production of panose (up to 37.53 mM), an oligosaccharide known for its prebiotic effect. A4X, Z36P and B12 showed dextranase hydrolytic enzymatic activity and were able to produce another trisaccharide, maltotriose, which is the first instance of a dextranase activity encoded by Lc. mesenteroides strains. Furthermore, B12 and O9 grew in the absence of riboflavin (vitamin B2) and synthesized this vitamin, in a defined medium at the level of ~ 220 μg/L. Therefore, these LAB, especially Lc. mesenteroides B12, are good candidates for the development of new fermented food biofortified with functional compounds.
Disrupted Tuzzerella abundance and impaired l-glutamine levels induce Treg accumulation in ovarian endometriosis: a comprehensive multi-omics analysis
Authors: Chen Yichen , Ye Lingfang , Zhu Jue , Chen Liang , Chen Huan , Sun Yuhui , Rong Yishen , Zhang Jing 
Published: February 2024

Abstract
Introduction
The microbial community plays a crucial role in the pathological microenvironment. However, the structure of the microbial community within endometriotic lesions and its impact on the microenvironment is still limited.

Methods
All 55 tissue samples, including ovarian ectopic (OEMs) and normal (NE) endometrium, were subjected to 16S rRNA sequencing, metabolomic and proteomic analysis.

Results
We found the abundance of Tuzzerella is significantly lower in OEMs compared to NE tissue (p < 0.01). We selected samples from these two groups that exhibited the most pronounced difference in Tuzzerella abundance for further metabolomic and proteomic analysis. Our findings indicated that endometriotic lesions were associated with a decrease in l-Glutamine levels. However, proteomic analysis revealed a significant upregulation of proteins related to the complement pathway, including C3, C7, C1S, CLU, and A2M. Subsequent metabolic and protein correlation predictions demonstrated a negative regulation between l-Glutamine and C7. In vitro experiments further confirmed that high concentrations of Glutamine significantly inhibit C7 protein expression. Additionally, immune cell infiltration analysis, multiplex immunofluorescence, and multifactorial testing demonstrated a positive correlation between C7 expression and the infiltration of regulatory T cells (Tregs) in ectopic lesions, while l-Glutamine was found to negatively regulate the expression of chemotactic factors for Tregs.

Conclusion
In this study, we found a clear multi-omics pathway alteration, “Tuzzerella (microbe)—l-Glutamine (metabolite)—C7 (protein),” which affects the infiltration of Tregs in endometriotic lesions. Our findings provide insights into endometriosis classification and personalized treatment strategies based on microbial structures.

Graphical abstract
Preclinical assessments of safety and tumorigenicity of very high doses of allogeneic human umbilical cord mesenchymal stem cells
Authors: Chin Sze-Piaw , Saffery Nik Syazana , Then Kong-Yong , Cheong Soon-Keng 
Published: February 2024

AbstractHuman umbilical cord-mesenchymal stem cells (hUC-MSCs) have been widely investigated as a new therapeutic agent to treat injuries and inflammatory-mediated and autoimmune diseases. Previous studies have reported on the safety of low-dose infusion of hUC-MSCs, but information on the cell behaviour at higher doses and frequency of injection of the cells remains uncertain. The aim of the present study was to demonstrate the safety and efficacy of hUC-MSCs by Cytopeutics® (Selangor, Malaysia) from low to an extremely high dose in different monitoring periods in healthy BALB/c mice as well as assessing the tumorigenicity of the cells in B-NDG SCID immunocompromised mice. Umbilical cord from two healthy human newborns was obtained and the isolation of the hUC-MSCs was performed based on previous established method. Assessment of the cells at different doses of single or multiple administrations was performed on healthy BALB/c mice in dose range finding, sub-acute (7 d and 28 d) and sub-chronic periods (90 d). Tumorigenicity potential of Cytopeutics® hUC-MSCs was also evaluated on B-NDG immunocompromised mice for 26 wk. Single or multiple administrations of Cytopeutics® hUC-MSCs up to 40 × 106 cells per kilogramme of body weight (kg BW) were found to have no adverse effect in terms of clinical symptoms, haematology and other laboratory parameters, and histology examination in healthy BALB/c mice. hUC-MSCs were also found to reduce pro-inflammatory cytokines (IL-6 and TNF-α) in a dose-dependent manner. No sign of tumor formation was observed in B-NDG mice in the 26-wk tumorigenicity assessment. Single or multiple administration of allogenic Cytopeutics® hUC-MSCs was safe even at very high doses, is non-tumorigenic and did not cause adverse effects in mice throughout the evaluation periods. In addition, Cytopeutics® hUC-MSCs exhibited immunomodulatory effect in a dose-dependent manner.
From Integration Policies to Belonging: Local Integration Workers’ Boundary Construction Concerning Immigrants in Rural Areas
Authors: Enbuska Marja 
Published: February 2024

AbstractThe concept of integration implies an imbalance between people, where immigrants are those who are obligated to integrate into the society of a new country. Thus, I suggest that alongside of integration, the focus should be the process of belonging and to how different local actors participate in the belonging process. In this study, I examine how people who try to promote immigrants’ integration, namely local migration coordinators, project employees and volunteers, create immigrants’ belonging in rural Finland. The data consist of fourteen semi-structured interviews. My research questions are (1) What symbolic boundaries do local integration workers construct when they speak about immigrants and their integration? and (2) What kind of belonging do they (re)produce for immigrants through these boundaries? I argue that local integration workers establish a notion of belonging that follows the official, national integration policy on language, employment, active membership, and individual immigrants’ adaptation. However, they simultaneously expand the boundaries of belonging by highlighting the responsibility of the local community in the process, and by emphasising immigrants’ personal desires, individuality and experiences of a sense of being at home.
Maximizing ollie height by optimizing control strategy and skateboard geometry using direct collocation
Authors: Heinen Jan T. , Brockie Samuel G. , ten Broek Raymund , van der Kruk Eline , Moore Jason K. 
Published: February 2024

AbstractThe ollie is the base aerial human–board maneuver, foundational to most modern skateboarding tricks. We formulate and solve an optimal control problem of a two-dimensional simplified human model and a rigid body skateboard with the objective of maximizing the height of the ollie. Our solution simultaneously discovers realistic human-applied force trajectories and optimal board geometry. We accomplish this with a direct collocation formulation using a null seed initial guess by carefully modeling the discontinuous aspects of board–ground impact and foot–board friction. This leads to efficient and robust solutions that are 10 times more computationally efficient than prior work on similar problems. The solutions show that ollie height can increase 3% by decreasing the wheelbase and that a smaller board with a back-foot-dominated force strategy can give 12% higher ollies. Our model can be used to inform jump strategy and the effects of changes to the essential board geometry.