bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards a tailored approach for patients with acute diverticulitis and abscess formation. The DivAbsc2023 multicentre case–control study
Authors: Podda Mauro , Ceresoli Marco , Di Martino Marcello , Ortenzi Monica , Pellino Gianluca , Pata Francesco , Ielpo Benedetto , Murzi Valentina , Balla Andrea , Lepiane Pasquale , Tamini Nicolo’ , De Carlo Giulia , Davolio Alessia , Di Saverio Salomone , Cardinali Luca , Botteri Emanuele , Vettoretto Nereo , Gelera Pier Paolo , De Simone Belinda , Grasso Antonella , Clementi Marco , Meloni Danilo , Poillucci Gaetano , Favi Francesco , Rizzo Roberta , Montori Giulia , Procida Giuseppa , Recchia Irene , Agresta Ferdinando , Virdis Francesco , Cioffi Stefano Piero Bernardo , Pellegrini Martina , Sartelli Massimo , Coccolini Federico , Catena Fausto , Pisanu Adolfo 
Published: April 2024

Abstract
Background
This multicentre case–control study aimed to identify risk factors associated with non-operative treatment failure for patients with CT scan Hinchey Ib-IIb and WSES Ib-IIa diverticular abscesses.

Methods
This study included a cohort of adult patients experiencing their first episode of CT-diagnosed diverticular abscess, all of whom underwent initial non-operative treatment comprising either antibiotics alone or in combination with percutaneous drainage. The cohort was stratified based on the outcome of non-operative treatment, specifically identifying those who required emergency surgical intervention as cases of treatment failure. Multivariable logistic regression analysis to identify independent risk factors associated with the failure of non-operative treatment was employed.

Results
Failure of conservative treatment occurred for 116 patients (27.04%). CT scan Hinchey classification IIb (aOR 2.54, 95%CI 1.61;4.01, P < 0.01), tobacco smoking (aOR 2.01, 95%CI 1.24;3.25, P < 0.01), and presence of air bubbles inside the abscess (aOR 1.59, 95%CI 1.00;2.52, P = 0.04) were independent predictors of failure. In the subgroup of patients with abscesses > 5 cm, percutaneous drainage was not associated with the risk of failure or success of the non-operative treatment (aOR 2.78, 95%CI − 0.66;3.70, P = 0.23).

Conclusions
Non-operative treatment is generally effective for diverticular abscesses. Tobacco smoking's role as an independent risk factor for treatment failure underscores the need for targeted behavioural interventions in diverticular disease management. IIb Hinchey diverticulitis patients, particularly young smokers, require vigilant monitoring due to increased risks of treatment failure and septic progression. Further research into the efficacy of image-guided percutaneous drainage should involve randomized, multicentre studies focussing on homogeneous patient groups.

Graphical abstract
Lasers in the management of alopecia: a review of established therapies and advances in treatment
Authors: Jean-Pierre Philippe , Pulumati Anika , Kasheri Eli , Hirsch Melanie , Nouri Keyvan 
Published: April 2024

Abstract
Alopecia, also known as hair loss, is a highly prevalent condition affecting millions of men and women in the United States and worldwide, making it one of the most common complaints by patients presenting to a dermatologist. The symptomology on the presentation of alopecia can be highly variable, ranging from diffuse thinning of hair, discrete and localized patches completely absent of hair, or noticing significant shedding when brushing and showering. Although alopecia does not have a direct negative health impact on patients, it is nonetheless a debilitating disease as it can profoundly impact an individual’s self-image and psychosocial well-being. There are multiple treatment options available to patients with alopecia, and they are typically tailored to the patient’s needs and preferences. The most common of these is the Food and Drug Administration-approved drugs for alopecia, minoxidil, and finasteride. However, both of these are known to be partially efficacious for all patients, so clinicians often use different modalities in conjunction with them, in particular laser-based therapies. This review article will provide a comprehensive assessment of lasers and other light therapies that may be used to manage the two most common types of alopecia: androgenetic alopecia and alopecia areata.
Comparison of trace elements in peripheral blood and bone marrow of newly diagnosed multiple myeloma patients
Authors: Kul Ayse Nilgun , Ozturk Kurt Bahar 
Published: April 2024

AbstractTrace elements are essential micronutrients for the human body. Their roles are indispensable, as they are involved in a wide range of vital biological processes. In this study, we aimed to evaluate alterations in trace elements in the blood and bone marrow serum of patients with newly diagnosed multiple myeloma (NMM). The levels of zinc (Zn), copper (Cu), iron (Fe), manganese (Mn), magnesium (Mg), selenium (Se), arsenic (As), boron (B), nickel (Ni), silicon (Si) and chromium (Cr) were analyzed in the venous blood samples of the patient group comprising 70 patients with NMM (41 males and 29 females) and compared to those in the control group comprising 30 individuals (18 males and 12 females). In addition, trace element levels were analyzed in bone marrow samples from the patient group. Blood and bone marrow serum levels were quantified using inductively coupled plasma optical emission spectrometry. When the blood samples of the patient and control groups were compared: Zn (p = 0.011), Fe (p = 0.008), Mn (p = 0.046), Se (p < 0.001), As (p < 0.001), Ni (p < 0.001) and Cr (p < 0.001) levels were significantly higher in the patient group than in the control group. Higher Zn, Fe, Mn, Se, As, Ni and Cr levels in the NMM patients suggest that alterations of trace elements could be predisposing factor that initiates the malignant process. The relationship between malignancies and trace elements is crucial for the development of adjuvant therapy strategies and preventive medicine and as biomarkers for cancer diagnosis. Therefore, there is a need for studies examining the relationship between hematological malignancies and trace elements.
Signifiers for conveying and exploiting affordances: from human-computer interaction to multi-agent systems
Authors: Lemée Jérémy , Vachtsevanou Danai , Mayer Simon , Ciortea Andrei 
Published: April 2024

AbstractThe ecological psychologist James J. Gibson defined the notion of affordances to refer to what action possibilities environments offer to animals. In this paper, we show how (artificial) agents can discover and exploit affordances in a Multi-Agent System (MAS) environment to achieve their goals. To indicate to agents what affordances are present in their environment and whether it is likely that these may help the agents to achieve their objectives, the environment may expose signifiers while taking into account the current situation of the environment and of the agent. On this basis, we define a Signifier Exposure Mechanism that is used by the environment to compute which signifiers should be exposed to agents in order to permit agents to only perceive information about affordances that are likely to be relevant to them, and thereby increase their interaction efficiency. If this is successful, agents can interact with partially observable environments more efficiently because the signifiers indicate the affordances they can exploit towards given purposes. Signifiers thereby facilitate the exploration and the exploitation of MAS environments. Implementations of signifiers and of the Signifier Exposure Mechanism are presented within the context of a Hypermedia Multi-Agent System, and the utility of this approach is presented through the development of a scenario.
Pyrroloquinoline quinone protects against murine hepatitis virus strain 3-induced fulminant hepatitis by inhibiting the Keap1/Nrf2 signaling
Authors: Pu Zunguo , Ge Fei , Zhou Yaqing , Liu Aiming , Yang Chao 
Published: April 2024

AbstractFulminant hepatitis (FH) is a life-threatening clinical liver syndrome characterized by substantial hepatocyte necrosis and severe liver damage. FH is typically associated with severe oxidative stress, inflammation, and mitochondrial dysfunction. Pyrroloquinoline quinone (PQQ), a naturally occurring redox cofactor, functions as an essential nutrient and antioxidant and reportedly inhibits oxidative stress and exerts potent anti-inflammatory effects. In the present study, we aimed to evaluate the therapeutic efficacy of PQQ in murine hepatitis virus strain 3 (MHV-3)-induced FH and examined the underlying mechanism. An MHV-3-induced FH mouse model was established for in vivo examination. Liver sinusoidal endothelial cells (LSECs) were used for in vitro experiments. Herein, we observed that PQQ supplementation significantly attenuated MHV-3-induced hepatic injury by suppressing inflammatory responses and reducing oxidative stress. Mechanistically, PQQ supplementation ameliorated MHV-3-induced hepatic damage by down-regulating the Keap1/Nrf2 signaling pathway in vivo and in vitro. Furthermore, Nrf2 small interfering RNA targeting LSECs abrogated the PQQ-mediated protective effects against MHV-3-related liver injury. Our results deepen our understanding of the hepatoprotective function of PQQ against MHV-3-induced liver injury and provide evidence that alleviating oxidative stress might afford a novel therapeutic strategy for treating FH.
A novel asymptotically consistent approximation for integral evaporation from a spherical cap droplet
Authors: Wray Alexander W. , Moore Madeleine R. 
Published: April 2024

AbstractThe total evaporation rate due to a volatile capillarity-dominated droplet diffusively evaporating into the surrounding gas is a critically important quantity in industrial and engineering applications such as Q/OLED screen manufacturing. However, the analytical expression in terms of integrals in toroidal coordinates can be unwieldy in applications, as well as expensive to compute. Therefore, simple yet highly accurate approximate solutions are frequently used in practical settings. Herein we present a new approximate form that is both accurate and fast to compute, but also retains the correct asymptotic behaviour in the key physical regimes, namely hydrophilic and superhydrophobic substrates, and a hemispherical droplet. We illustrate this by comparison to several previous approximations and, in particular, illustrate its use in calculating droplet lifetimes, as well as approximating the local evaporative flux.
A novel time-dependent analytical model for optimizing efficiency and valve timing in Ericsson engines
Authors: Tzouganakis Panteleimon , Gakos Vasilios , Kalligeros Christos , Papalexis Christos , Spitas Vasilios 
Published: April 2024

AbstractIn this work, a novel analytical time-sensitive model for Ericsson engines was developed taking into account the heat transfer phenomena between the working gas and the cylinder walls in the compressor and the expander. For the calculation of the mass flow entering/exiting each cylinder, another dedicated flow model was developed to account for the pressure drop at the valves. From the energy equilibrium taking into consideration the time-dependent thermal response of the cylinder walls and the enthalpy entering/exiting each cylinder through the valves, an analytical solution of the working gas pressure and temperature can be obtained for every time step and consequently, the thermal efficiency of the engine can be calculated. A case study was performed where the thermal efficiency of an Ericsson engine was calculated for different rotational speeds and heat exchanger gas temperatures. It was observed that with higher temperatures thermal efficiency maintained a more stable behaviour with a weak dependence on rotational speed. The thermal efficiency of the engine in the performed case studies was found in the range of 10% to 14%. The valve timing of the Ericsson engine was optimized in order to achieve the highest thermal efficiency possible. The thermal efficiency of the engine could be increased up to 26% as a percentage after a thorough optimization of the valve timing. Finally, backflow phenomena accounting for thermal efficiency drop were studied. The developed model can also be applied to other types of external combustion engines such as Stirling engines.
Making Science Relevant: Comparing Two Science Advisory Organizations Beyond the Linear Knowledge Model
Authors: Sundqvist Göran , Linke Sebastian 
Published: April 2024

AbstractThis article compares two science advisory organizations: the Intergovernmental Panel for Climate Change (IPCC) and the International Council for the Exploration of the Seas (ICES), with a special focus on how their respective policy systems absorb the knowledge delivered for use in decision processes. The science-policy processes of these two organizations differ in important respects; ICES delivers highly specified knowledge to a specified uptake mechanism, while the IPCC produces unspecified knowledge for an unspecified uptake mechanism. Since both environmental governance areas are criticized for lack of needed action, a comparison is of interest asking how this might relate to the organization of science advice. As theoretical resources for this explorative comparison we utilize two approaches from the field of science and technology studies: the co-production approach, which focuses on the entanglements of scientific and political processes, and the systems-theory-oriented multiple-worlds model, which assumes a clear difference in institutional logics between the scientific and the political field. Since the IPCC has been critically analysed by several studies utilizing resources from the two approaches, we contribute with new insights by bringing in ICES, which is a much less studied organization exposing a different science-policy structure. One important finding is that the two theoretical approaches focus on different aspects, exposing ‘links’ and ‘integration’, both of which we argue are important for analysing and assessing science advisory organizations. Moreover, these aspects can be advantageously integrated into a single theoretical framework.
Antimicrobial Activity Classification of Imidazolium Derivatives Predicted by Artificial Neural Networks
Authors: Lorenc Andżelika , Badura Anna , Karolak Maciej , Pałkowski Łukasz , Kubik Łukasz , Buciński Adam 
Published: April 2024

Abstract
Purpose
This study assesses the Multilayer Perceptron (MLP) neural network, complemented by other Machine Learning techniques (CART, PCA), in predicting the antimicrobial activity of 140 newly designed imidazolium chlorides against Klebsiella pneumoniae before synthesis. Emphasis is on leveraging molecular properties for predictive analysis.

Methods
Classification and regression decision trees (CART) identified the top 200 predictive molecular descriptors. Principal Component Analysis (PCA) reduced these descriptors to 5 components, retaining 99.57% of raw data information. Antimicrobial activity, categorized as high or low, was based on experimentally proven minimal inhibitory concentration (MIC), with a cut-point at MIC = 0.856 mol/L. A 12-fold cross-validation trained the MLP (architecture 5-12-2 with 5 Principal Components).

Results
The MLP exhibited commendable performance, achieving almost 90% correct classifications across learning, validation, and test sets, outperforming models without PCA dimension reduction. Key metrics, including accuracy (0.907), sensitivity (0.905), specificity (0.909), and precision (0.891), were notably high. These results highlight the MLP model's efficacy with PCA as a high-quality classifier for determining antimicrobial activity.

Conclusions
The study concludes that the MLP neural network, along with CART and PCA, is a robust tool for predicting the antimicrobial activity class of imidazolium chlorides against Klebsiella pneumoniae. CART and PCA, used in this study, allowed input variable reduction without significant information loss. High classification accuracy and associated metrics affirm the method’s potential utility in pre-synthesis assessments, offering valuable insights for antimicrobial compound design.
Spatial biases in processing mirror letters by literate subjects
Authors: Patro Katarzyna , Gross Antonia , Friedrich Claudia 
Published: April 2024

AbstractPreschool children often confuse letters with their mirror images when they try to read and write. Mirror confusion seems to occur more often in line with the direction of script (e.g., left-to-right for the Latin alphabetic script), suggesting that the processing of letter orientation and text directionality may be interrelated in preliterate age. When children go to school, mirror mistakes in writing/reading letters disappear. Here we ask whether the processing of letter shapes and text direction are still related in readers at different proficiency levels. Literate subjects – school children from the 1st and 4th grades and adults – decided under time pressure whether a displayed letter was oriented correctly or incorrectly (mirrored). We observed that reaction times were faster when a letter was oriented rightward, i.e. in line with the cultural text direction (left-to-right), but we did not find any differences between the groups. We conclude that, even if mirror mistakes disappear during primary school years, letter shapes are still processed in a close relation to the left-to-right reading direction in the Latin script.
Exploring the writing attainment gap: profiling writing challenges and predictors for children with English as an additional language
Authors: Booton Sophie A. , Menon Prerna , Kyriacou Maria , Murphy Victoria A. 
Published: April 2024

AbstractWhile there is some evidence of a gap in English writing achievement between children with English as an additional language (EAL) compared to their monolingual English-speaking (EL1) peers, the source of this gap remains unclear. This study examines whether writing presents a specific challenge for children with EAL beyond their oral language and reading skills, and whether the factors affecting writing skills differ between EAL and EL1 groups. In a longitudinal design, 100 children aged 9 to 10 years completed a fiction writing task and single-word spelling task twice over a school year. They also completed a non-fiction writing task, and measures of nonverbal intelligence, receptive vocabulary, expressive and receptive oral language, decoding, and reading comprehension. Children with EAL demonstrated lower general writing performance than monolinguals, commensurate with their other language and reading skills, but a relative strength in single-word spelling. Predictors were similar for children with EAL and monolinguals, with decoding skill predicting spelling and writing, and expressive oral language predicting writing. Effects of genre and specific writing sub-skills are also discussed, as well as implications for closing the writing attainment gap.
The Egyptian national HPC grid (EN-HPCG): open-source Slurm implementation from cluster to grid approach
Authors: Elshambakey Mohammed , Maiyza Aya I. , Kashkoush Mona S. , Fathy Ghada M. , Hassan Hanan A. 
Published: April 2024

AbstractRecently, Egypt has recognized the pivotal role of High Performance Computing in advancing science and innovation. Additionally, Egypt realizes the importance of collaboration between different institutions and universities to consolidate their own computational and data resources into a unified platform to serve different disciplines (e.g., scientific, industrial, governmental). Otherwise, additional resources would be needed to be purchased with the associated cost, effort, and time difficulties (e.g., setup, administration, maintenance, etc.). Thus, this paper delves into the architecture and capabilities of the EN-HPCG grid using two different workload management systems: (i) Slurm (Open-Source) and (ii) PBS Pro (Licensed). This paper compares the performance of the grid between Slurm and PBS Pro in specific high-throughput computing (HTC) applications using the NAS Grid parallel benchmark (NGB) to determine which workload manager is more suitable for EN-HPCG. The evaluation includes grid-level performance metrics such as throughput, and the number of tasks completed as a function of time. Also, the presented methodology aims to assist potential partners in their decision-making process to join the EN-HPCG grid, with a focus on the site speed-up metric. Our results showed that, unless an open-source solution without cost and license problems is an obligation (in which case, Slurm is the viable solution), then it is not advisable to integrate a cluster with high-speed hardware with a cluster possessing outdated hardware when using the Slurm scheduler. In contrast, the PBS Pro scheduler takes into account online decision-making in a dynamic environment using a unified grid.
Exploring raw data transformations on inertial sensor data to model user expertise when learning psychomotor skills
Authors: Portaz Miguel , Corbi Alberto , Casas-Ortiz Alberto , Santos Olga C. 
Published: April 2024

AbstractThis paper introduces a novel approach for leveraging inertial data to discern expertise levels in motor skill execution, specifically distinguishing between experts and beginners. By implementing inertial data transformation and fusion techniques, we conduct a comprehensive analysis of motor behaviour. Our approach goes beyond conventional assessments, providing nuanced insights into the underlying patterns of movement. Additionally, we explore the potential for utilising this data-driven methodology to aid novice practitioners in enhancing their performance. The findings showcase the efficacy of this approach in accurately identifying proficiency levels and lay the groundwork for personalised interventions to support skill refinement and mastery. This research contributes to the field of motor skill assessment and intervention strategies, with broad implications for sports training, physical rehabilitation, and performance optimisation across various domains.
A case report of acute claudication due to vena cava thromboembolism in a dog naturally infected with Leishmania Infantum
Authors: Calvo-Sánchez Natalia , Gómez Álex , Pérez Estela , Borobia María , Luján Lluís , Fernández Antonio , Villanueva-Saz Sergio , Verde Maite , Marteles Diana 
Published: April 2024

AbstractCanine leishmaniosis is a vector-borne disease caused byLeishmania infantum, and clinical manifestations of infection range from absent or severe to fatal and result from immune-mediated mechanisms. In dogs, the most common clinical signs of leishmaniosis include skin lesions and lymphadenomegaly. However, the presence of other nontypical signs has been described, and diagnosing these cases can be challenging. The aim of the present short communication was to describe the impact of the formation of circulating immunocomplexes due toL. infantumin a dog with leishmaniosis affected by a massive venous thrombus of the caudal vena cava and external iliac veins. On admission, the dog presented bilateral cutaneous vasculopathy of the thigh and renal disease due toL. infantuminfection. Two weeks after starting anti-Leishmaniatreatment based on meglumine antimoniate and allopurinol administration, the animal developed acute claudication of the hind limbs with the presence of a thrombus in the caudal vena cava and the external iliac veins and a high level of circulating immunocomplexes detected by enzyme-linked immunosorbent assay. Exacerbation of the humoral immune response, along with deposition of circulating immune complexes in the tissues and the concurrent presence of kidney and liver damage, might have contributed to an imbalance in haemostasis in this patient. Future studies should evaluate and analyse the pathological mechanisms contributing to thrombosis in dogs with leishmaniosis.