bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations Between Healthy Behaviors and Persistently Favorable Self-Rated Health in a Longitudinal Population-Based Study in Switzerland
Authors: Nehme Mayssam , Schrempft Stephanie , Baysson Helene , Pullen Nick , Rouzinov Serguei , Stringhini Silvia ,   Speccio Study Group, Bal Antoine , Bouhet Aminata Rosalie , D’ippolito Paola , Dumont Roxane , Merjani Nacira El , Francioli Natalie , Harnal Severine , Joost Stephane , Kathari Gabriel , Lamour Julien , Loizeau Andrea Jutta , Lorthe Elsa , Martinez Chantal , Mecoullam Shannon , Pugin Caroline , Richard Viviane , Uppal Anshu , Villers Jennifer , Zaballa María-Eugenia , Guessous Idris 
Published: March 2024

Abstract
Background
Self-rated health is a subjective yet valuable indicator of overall health status, influenced by various factors including physical, psychological, and socio-economic elements. Self-rated health could be telling and used by primary care physicians to evaluate overall present and predictive health.

Design
This study investigates the longitudinal evolution of self-rated health in Switzerland during the COVID-19 pandemic, focusing on the association of persistently favorable self-rated health with various predictors.

Participants
This study based on the Specchio cohort, a population-based digital study in Geneva Switzerland, involved participants completing questionnaires from 2021 to 2023.

Main Measures
Self-rated health was assessed alongside factors like physical and mental health, socio-economic status, and lifestyle behaviors.

Key Results
The study included 7006 participants in 2021, and 3888 participants who answered all three follow-ups (2021, 2022, and 2023). At baseline, 34.9% of individuals reported very good, 54.6% reported good, 9.6% reported average, and 1.0% reported poor to very poor self-rated health. Overall, 29.1% had a worsening in their self-rated health between 2021 and 2023. A subset of participants (12.1%) maintained very good self-rated health throughout, demonstrating persistently favorable self-rated health during the COVID-19 pandemic. Positive health behaviors were associated with persistently favorable self-rated health (exercise aOR 1.13 [1.03–1.24]; healthy diet aOR 2.14 [1.70–2.68]; less screen time aOR 1.28 [1.03–1.58]; and better sleep quality aOR 2.48 [2.02–3.04]). Mental health and social support also played significant roles.

Conclusion
The study underscores the significance of healthy lifestyle choices and social support in maintaining favorable self-rated health, particularly during challenging times like the COVID-19 pandemic. Primary care physicians should focus on promoting these factors, integrating these actions in their routine consultations, and advising patients to undertake in socially engaging activities to improve overall health perceptions and outcomes.
Diet, exercise, and supplements: what is their role in the management of the metabolic dysfunction-associated steatotic liver disease in children?
Authors: Serbis Anastasios , Polyzos Stergios A. , Paschou Stavroula A. , Siomou Ekaterini , Kiortsis Dimitrios N. 
Published: March 2024

AbstractMetabolic dysfunction-associated steatotic liver disease (MASLD), previously known as nonalcoholic fatty liver disease (NAFLD), is the main cause of chronic liver disease in children and adolescents. Indeed, epidemiological studies have shown that MASLD affects up to 40% of children with obesity. Despite the recent approval of medications that target weight loss in adolescents that could have benefits on pediatric MASLD, lifestyle interventions, such as diet and exercise, remain the mainstay of our therapeutic approach. More specifically, studies on diet alone have focused on the possible role of carbohydrate or fat restriction, albeit without a definite answer on the best approach. Weight loss after dietary intervention in children with obesity and MASLD has a beneficial effect, regardless of the diet used. In relation to the role of exercise in MASLD reversal, indirect evidence comes from studies showing that a sedentary lifestyle leading to poor fitness, and low muscle mass is associated with MASLD. However, research on the direct effect of exercise on MASLD in children is scarce. A combination of diet and exercise seems to be beneficial with several studies showing improvement in surrogate markers of MASLD, such as serum alanine aminotransferase and hepatic fat fraction, the latter evaluated with imaging studies. Several dietary supplements, such as vitamin E, probiotics, and omega-3 fatty acid supplements have also been studied in children and adolescents with MASLD, but with equivocal results. This review aims to critically present available data on the effects of lifestyle interventions, including diet, exercise, and dietary supplements, on pediatric MASLD, thus suggesting a frame for future research that could enhance our knowledge on pediatric MASLD management and optimize clinicians’ approach to this vexing medical condition.
Perception–Intention–Action Cycle in Human–Robot Collaborative Tasks: The Collaborative Lightweight Object Transportation Use-Case
Authors: Domínguez-Vidal J. E. , Rodríguez Nicolás , Sanfeliu Alberto 
Published: March 2024

AbstractThis study proposes to improve the reliability, robustness and human-like nature of Human–Robot Collaboration (HRC). For that, the classical Perception–Action cycle is extended to a Perception–Intention–Action (PIA) cycle, which includes an Intention stage at the same level as the Perception one, being in charge of obtaining both the implicit and the explicit intention of the human, opposing to classical approaches based on inferring everything from perception. This complete cycle is exposed theoretically including its use of the concept of Situation Awareness, which is shown as a key element for the correct understanding of the current situation and future action prediction. This enables the assignment of roles to the agents involved in a collaborative task and the building of collaborative plans. To visualize the cycle, a collaborative transportation task is used as a use-case. A force-based model is designed to combine the robot’s perception of its environment with the force exerted by the human and other factors in an illustrative way. Finally, a total of 58 volunteers participate in two rounds of experiments. In these, it is shown that the human agrees to explicitly state their intention without undue extra effort and that the human understands that this helps to minimize robot errors or misunderstandings. It is also shown that a system that correctly combines inference with explicit elicitation of the human’s intention is the best rated by the human on multiple parameters related to effective Human–Robot Interaction (HRI), such as perceived safety or trust in the robot.
Pre-operative assessment of living liver donors’ liver anatomy and volumes
Authors: Goldaracena Nicolas , Vargas Paola A. , McCormack Lucas 
Published: March 2024

AbstractDecades of experience supports LDLT as a favorable strategy to reduce waitlist mortality. The multiple regenerative pathways of hepatocytes and other hepatic cells justify the rationale behind it. Nonetheless, living liver donation is still underused and its broader implementation is challenging, mostly due to variability in practices leading to concerns related to donor safety. A non-systematic literature search was conducted for peer-reviewed original articles related to pre-operative evaluation of living liver donor candidates. Eligible studies were synthesized upon consensus for discussion in this up-to-date review. Review of the literature demonstrate that the importance of preoperative assessment of vascular, biliary and liver volume to ensure donor safety and adequate surgical planning for graft procurement is widely recognized. Moreover, data indicates that anatomic variants in vascular and biliary systems in healthy donors are common, present in up to 50% of the population. Therefore, comprehensive mapping and visualizations of each component is needed. Different imaging modalities are reported across practices and are discussed in detail. Lastly, assessment of liver volume must take into account several technical and donor factors that increase the chances of errors in volume estimation, which occurs in up to 10% of the cases. Experience suggests that maximizing donor safety and lessening their risks is a result of integrated experience between hepatobiliary and transplant surgery, along with multidisciplinary efforts in performing a comprehensive pre-operative donor assessment. Although technical advances have increased the accuracy of volume estimation, over- or under-estimation remains a challenge that needs further attention.
A mathematical description of the Weber nucleus as a classical and quantum mechanical system
Authors: Frauenfelder Urs , Weber Joa 
Published: March 2024

AbstractWilhelm Weber’s electrodynamics is an action-at-a-distance theory which has the property that equal charges inside a critical radius become attractive. Weber’s electrodynamics inside the critical radius can be interpreted as a classical Hamiltonian system whose kinetic energy is, however, expressed with respect to a Lorentzian metric. In this article we study the Schrödinger equation associated with this Hamiltonian system, and relate it to Weyl’s theory of singular Sturm–Liouville problems.
Effects of Therapy at a Community Based Trauma Therapy Service Treating Child Abuse and Neglect: A Pre-Post Study Using Administrative Data
Authors: Herbert James Leslie , Paton Amanda 
Published: March 2024

AbstractThis repeated-measures study examined the effects of a hybrid of Trauma-Focused Cognitive Behavioural Therapy (TF-CBT) with other therapeutic approaches at a community-based clinic in Perth Western Australia among a sample of children and young people overwhelmingly experiencing multiple forms of maltreatment and with complex family situations (i.e., family and domestic violence, parental mental health, parental substance abuse). Drawing on 1713 individual client records from between 2017 and 2020, the researchers identified 113 children and young people with viable pre-post treatment assessments including 78 on the TSCC, 36 on the TSCYC, and 12 on the CBCL. Significant improvements on most clinical scales were identified on the TSCC and TSCYC. Sub-analysis of the TSCC results found no differences across gender, age, care status, therapy funding source, and the presence of sexual abuse in the rate of improvement on trauma symptoms. Overall, the study highlights that integrating different therapy approaches for populations with multiple and complex trauma symptoms accessing community-based services can be useful for supporting the delivery of TF-CBT for difficult to treat populations.
Impact of ecological migration village construction on vector mosquito and mosquito-borne disease in the southern Yunnan Province, China
Authors: Liu Mei-De , Li Chun-Xiao , Wang Xue-Zhong , Dong Yan-De , Zhao Tong-Yan 
Published: March 2024

AbstractTo evaluate the influence of ecological migration village construction on mosquito vector populations and mosquito-borne diseases in southern Yunnan Province. Two vicinal villages in Mengla County, the southern part of Yunnan Province, a native village, and a newly built village, were selected as study sites. Malaria and Japanese Encephalitis vector mosquito population divergence between the two villages were studied. Malaria and Japanese Encephalitis (JE) cases in the two villages were also compared. Anopheles minimus was the dominant population in houses in the newly built village, and An. jeyporiensis dominated the native village. Accordingly, there were nine malaria cases in the new village compared with zero cases in the native village. Culex tritaeniorhynchus, the chief JE vector in the study area, displayed no difference between the two villages; however, there was a higher density of the local secondary JE vector (Cx. pseudovishnui) in the native village than in the new one. The JE cases in the villages corresponded to zero. From the vector-borne disease perspective, our results suggest that local community should pay more attention to malaria and An. minimus during the construction of an ecological migration village in the new Chinese Western Developing Plan (CWDP) in southern Yunnan Province.
Biochar-induced alterations in Acidithiobacillus ferrooxidans activity and its impact on Cd(II) and As(III) adsorption from acid mine drainage
Authors: Fu Peng , Chang Fangling , Yuan Dongxu , Wang Yanyan , Fan Yingxuan , Kang Yufan , Zhou Lixiang , Yang Chen , Bi Wenlong , Qin Junmei , Yang Hong , Liu Fenwu 
Published: March 2024

AbstractDue to continuing mining activities, Cd(II) and As(III) contamination in acid mine drainage (AMD) has become a major environmental challenge. Currently, there is increasing focus on the use of biochar to mitigate AMD pollution. However, the impact of biochar on the process of Fe(II) oxidation by Acidithiobacillus ferrooxidans (A. ferrooxidans) in AMD systems has not been determined. In this study, we investigated the effects of introducing biochar and biochar-leachate on Fe(II) biooxidation by A. ferrooxidans and on the removal of Cd(II) and As(III) from an AMD system. The results showed that the biochar-leachate had a promoting effect on Fe(II) biooxidation by A. ferrooxidans. Conversely, biochar inhibited this process, and the inhibition increased with increasing biochar dose. Under both conditions (c(A. ferrooxidans) = 1.4 × 107 copies mL–1, m(FeSO4·7H2O):m(biochar) = 20:1; c(A. ferrooxidans) = 7.0 × 107 copies mL–1, m(FeSO4·7H2O):m(biochar) = 5:1), the biooxidation capacity of A. ferrooxidans was severely inhibited, with Fe(II) oxidation efficiency reaching a value of only ~ 20% after 84 h. The results confirmed that this inhibition might have occurred because a large fraction of the A. ferrooxidans present in the system adsorbed to the biochar, which weakened bacterial activity. In addition, mineral characterization analysis showed that the introduction of biochar changed the A. ferrooxidans biooxidation products from schwertmannite to jarosite, and the specific surface area increased after the minerals combined with biochar. Coprecipitation experiments of As(III) and Cd(II) showed that Cd(II) was adsorbed by the biochar over the first 12 h of reaction, with a removal efficiency of ~ 26%. As(III) was adsorbed by the generated schwertmannite over 24 h, with a removal efficiency of ~ 100%. These findings have positive implications for the removal of As(III) and Cd(II) from AMD.
Graphical Abstract
Protease hydrolysed brewers’ spent grain bioactive extracts for applications in human health
Authors: Naik Azza Silotry , Brugiere Mila , Dunne Kevin , Sorohan Michael , Grasa Laura , Javed Bilal 
Published: March 2024

AbstractAbout 39 million tons of Brewer’s spent grain (BSG), the main by-product of beer manufacturing, are produced annually and is used for low value applications. To valorise this rich bioresource, the present work entails bioprocessing of BSG with various proteases (Novozymes) at two different concentrations (4% and 9%) to solubilise protein, carbohydrate and polyphenols from the grain and evaluate its effect on gut and brain health. The results show the highest (p < 0.05) FRAP (Ferric Reducing Antioxidant Power) based antioxidant activity was obtained for Pro 5 (4%: 108.10 ± 4.17 µmole Trolox Equivalence (TE)/g protein, 18.06 ± 0.70 µmole TE/g d.w., which was 3.6 times higher than untreated control extracts. The highest DPPH (1,1-diphenyl-2-picrylhydrazyl) scavenging activity was obtained for the same extract (Pro 5 at 4%: 0.118 ± 0.006 µg AAE/mg d.w., 9%: 0.110 ± 0.006 µg AAE/mg d.w). Proximate composition showed this extract to contain the highest concentration of proteins at 21.66% ± 2.71, and color analysis showed the same Pro 5 (4%) extract to be the darkest (L*53.73) indicating the possible presence of dark polyphenols. Anticancer screening showed Control and Pro 1 to possess cytotoxic effect against colon cancer cells with IC50 of 3.2 and 13.91 mg/mL, respectively. No significant activity was noted against the brain cancer cell line. Thus anti-colon cancer activity of BSG extracts highlights its potential in gut health. The observed bioactivity resulted from a combination of peptides, carbohydrates and polyphenolic compounds in the extract and warrants further characterisation for targeted nutraceutical applications.
Graphical abstract
Removal of rhodamine B and methylene blue using residual Onecarpus bacaba Mart fibers as biosorbent: kinetic and thermodynamic parameters
Authors: Rolim Eberlanny Moraes , da Silva Andreza Miranda Barata , dos Santos Batista Joel , Serrão Naiany Oliveira , Laier Leticia Oliveira , de Freitas Flávio Augusto , Perotti Gustavo Frigi , de Moura do Carmo Dominique Fernandes , de Gusmão Celestino Gustavo , Maia Paulo José Sousa 
Published: March 2024

AbstractAmong the most common water contaminants, dyes are responsible for polluting rivers and other water bodies as well as contributing to other environmental problems, thus posing serious health hazards to humans and animals. In order to minimize these environmental impacts, this study proposes the use of Onecarpus bacaba Mart fiber residues, in natura (OBMi) and NaOH-modified (OBMm), to bioadsorb rhodamine b (RhB) and methylene blue (MB) dyes. The biosorbents OBMi and OBMm were characterized by means of infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, Boehm titration, PZC, and scanning electron microscopy. This study also analyzed the influence of pH, contact time, absorbent mass, temperature, and contaminant concentrations by means of batch equilibrium assays. It was observed that the OBMi absorbent showed a low dye removal capacity. Maximum OBMm adsorption capacity for RhB and MB at 25 °C was 26.60 mg g−1 and 407.98 mg g−1, respectively. In both systems, OBMm:RhB and OBMm:MB, adsorption kinetics followed a pseudo-second-order model, and the Langmuir and Freundlich models constituted the best fit for isothermal curves. Lastly, thermodynamic parameters indicated that adsorption of both RhB and MB onto OBMm is spontaneous.
Explaining long-term trends in adolescent emotional problems: what we know from population-based studies
Authors: Armitage J. M. , Collishaw S. , Sellers R. 
Published: March 2024

AbstractOver the past four decades, rates of emotional problems in adolescents have increased in many countries, and outcomes for those with mental health problems have worsened. In this review we explore existing population-based studies to evaluate possible explanations for these trends. We include population-based studies that examine both trends in adolescent emotional problems, as well as risk or protective factors previously hypothesised to be associated with trends in youth depression and anxiety. The available evidence on risk or protective factors trends related to family life, young people’s health behaviours and lifestyle, school environment, peer relationships, as well as poverty. Studies reviewed suggest that trends in emotional problems are associated with increases in parental emotional problems, youth weight-control behaviours and eating disorders, school-related stress, as well as a rise in family poverty and social inequality in the 21st Century. One of the biggest changes in young people’s lives over the last few decades has been the rise of digital media to access information and interact with others, but implications for trends in mental health remain unclear. Other trends are likely to have mitigated against even steeper increases in youth emotional problems, for example improvements in youth substance use and a possible long-term reduction in child maltreatment. Epidemiological studies of unselected cohorts testing explanations for secular trends in mental health are scarce and an urgent priority for future research. Such studies will need to prioritise collection of comparable data in repeated population cohorts. Improving young people’s mental health is a major societal challenge, but considerably more needs to be done to understand the connections between social change and trends in youth mental health.
Modelling neurodegeneration and inflammation in early diabetic retinopathy using 3D human retinal organoids
Authors: de Lemos Luisa , Antas Pedro , Ferreira Inês S. , Santos Inês Paz , Felgueiras Beatriz , Gomes Catarina M. , Brito Catarina , Seabra Miguel C. , Tenreiro Sandra 
Published: March 2024

Abstract
Purpose
Diabetic retinopathy (DR) is a complication of diabetes and a primary cause of visual impairment amongst working-age individuals. DR is a degenerative condition in which hyperglycaemia results in morphological and functional changes in certain retinal cells. Existing treatments mainly address the advanced stages of the disease, which involve vascular defects or neovascularization. However, it is now known that retinal neurodegeneration and inflammation precede these vascular changes as early events of DR. Therefore, there is a pressing need to develop a reliable human in vitro model that mimics the early stage of DR to identify new therapeutic approaches to prevent and delay its progression.

Methods
Here, we used human-induced pluripotent stem cells (hiPSCs) differentiated into three-dimensional (3D) retinal organoids, which resemble the complexity of the retinal tissue. Retinal organoids were subjected to high-glucose conditions to generate a model of early DR.

Results
Our model showed well-established molecular and cellular features of early DR, such as (i) loss of retinal ganglion and amacrine cells; (ii) glial reactivity and inflammation, with increased expression of the vascular endothelial-derived growth factor (VEGF) and interleukin-1β (IL-1β), and monocyte chemoattractant protein-1 (MCP-1) secretion; and (iii) increased levels of reactive oxygen species accompanied by activation of key enzymes involved in antioxidative stress response.

Conclusion
The data provided highlight the utility of retinal organoid technology in modelling early-stage DR. This offers new avenues for the development of targeted therapeutic interventions on neurodegeneration and inflammation in the initial phase of DR, potentially slowing the disease’s progression.
Perioperative taurine or taurolidine supplementation on clinical outcomes: A systematic review with meta-analysis
Authors: Ho Kwok M. , Harahsheh Yusra 
Published: March 2024

AbstractTaurine is a conditionally essential amino acid that has been reported to have antioxidative and immunomodulatory effects either directly or through its interactions with gut microbiome. Although taurine has been widely used as a health supplement and also for treatment of congestive heart failure in Japan, its roles in the perioperative setting have not been well characterized. The purpose of this systematic review and meta-analysis was to assess whether oral or intravenous taurine, or its derivatives such as taurolidine, can offer benefits compared to placebo in the perioperative setting. Non-randomized studies, trials assessed topical taurine or taurolidine, or trials did not report clinical outcomes were excluded. Six randomized-controlled-trials (RCTs) involving a total of 596 adult surgical patients, in PubMed, MEDLINE and EMBASE databases on September 14, 2023 were identified and meta-analyzed using a fixed-effect model. Biases were assessed by reporting individual trial elements. Taurine or taurolidine (which is readily metabolized by hydrolysis to taurine) supplementation was associated with a reduction in all-cause infection (5 trials: pooled odds ratio (OR) 0.59; 95% confidence interval (CI) 0.38–0.92; p = 0.020) but not delirium (2 trials: OR 0.63, 95% CI 0.38–1.04; p = 0.071) or mortality (4 trials: OR 0.82, 95% CI 0.43–1.58; p = 0.557) compared to placebo. Using the ‘trim and fill’ technique to adjust for publication bias did not change the favorable effect of taurine on risk of infection (OR 0.61, 95% CI 0.40–0.95). Because the number of studies included was small, the promising benefits of taurine on risks of perioperative infection should be confirmed by adequately-powered RCTs.