bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyanide‐based Covalent Organic Frameworks for Enhanced Overall Photocatalytic Hydrogen Peroxide Production
Authors: Zhou Enbo , Wang Futong , Zhang Xiang , Hui Yangdan , Wang Yaobing 
Published: March 2024

AbstractPhotocatalytic oxygen reduction to produce hydrogen peroxide (H2O2) is a promising route to providing oxidants for various industrial applications. However, the lack of well‐designed photocatalysts for efficient overall H2O2 production in pure water has impeded ongoing research and practical thrusts. Here we present a cyanide‐based covalent organic framework (TBTN‐COFs) combining 2,4,6‐trimethylbenzene‐1,3,5‐tricarbonitrile (TBTN) and benzotrithiophene‐2,5,8‐tricarbaldehyde (BTT) building blocks with water‐affinity and charge‐separation. The ultrafast intramolecular electron transfer (<500 fs) and prolonged excited state lifetime (748 ps) can be realized by TBTN‐COF, resulting in a hole accumulated BTT and electron‐rich TBTN building block. Under one sun, the 11013 μmol h−1 g−1 yield rate of H2O2 can be achieved without any sacrificial agent, outperforming most previous reports. Furthermore, the DFT calculation and in situ DRIFTS spectrums suggesting a Yeager‐type absorption of *O2⋅− intermediate in the cyanide active site, which prohibits the formation of superoxide radical and revealing a favored H2O2 production pathway.
Cobalt Single‐Atom Reverse Hydrogen Spillover for Efficient Electrochemical Water Dissociation and Dechlorination
Authors: Zheng Qian , Xu Hengyue , Yao Yancai , Dai Jie , Wang Jiaxian , Hou Wei , Zhao Long , Zou Xingyue , Zhan Guangming , Wang Ruizhao , Wang Kaiyuan , Zhang Lizhi 
Published: March 2024

AbstractEfficient water dissociation to atomic hydrogen (H*) with restrained recombination of H* is crucial for improving the H* utilization for electrochemical dechlorination, but is currently limited by the lack of feasible electrodes. Herein, we developed a monolithic single‐atom electrode with Co single atoms anchored on the inherent oxide layer of titanium foam (Co1−TiOx/Ti), which can efficiently dissociate water into H* and simultaneously inhibit the recombination of H*, by taking advantage of the single‐atom reverse hydrogen spillover effect. Experimental and theoretical calculations demonstrated that H* could be rapidly generated on the oxide layer of titanium foam, and then overflowed to the adjacent Co single atom for the reductive dechlorination. Using chloramphenicol as a proof‐of‐concept verification, the resulting Co1−TiOx/Ti monolithic electrode exhibited an unprecedented performance with almost 100 % dechlorination at −1.0 V, far superior to that of traditional indirect reduction‐driven commercial Pd/C (52 %) and direct reduction‐driven Co1−N−C (44 %). Moreover, its dechlorination rate constant of 1.64 h−1 was 4.3 and 8.6 times more active than those of Pd/C (0.38 h−1) and Co1−N−C (0.19 h−1), respectively. Our research sheds light on the rational design of hydrogen spillover‐related electrocatalysts to simultaneously improve the H* generation, transfer, and utilization for environmental and energy applications.
Collective Synthesis of Highly Oxygenated (Furano)germacranolides Derived from Elephantopus mollis and Elephantopus tomentosus
Authors: Patouret Rémi , Cham Ning , Chiba Shunsuke 
Published: March 2024

AbstractGermacranolides, secondary metabolites produced by plants, have garnered academic and industrial interest due to their diverse and complex topology as well as a wide array of pharmacological activities. Molephantin, a highly oxygenated germacranolide isolated from medicinal plants, Elephantopus mollis and Elephantopus tomentosus, has exhibited antitumor, inflammatory, and leishmanicidal activities. Its chemical structure is based on a highly strained ten‐membered macrocyclic backbone with an (E,Z)‐dienone moiety, which is fused with an α‐methylene‐γ‐butyrolactone and adorned with four successive stereogenic centers. Herein, we report the first synthesis of molephantin in 12 steps starting from readily available building blocks. The synthesis features the highly diastereoselective intermolecular Barbier allylation of the β,γ‐unsaturated aldehyde with optically active 3‐bromomethyl‐5H‐furan‐2‐one intermediate and ensuing Nozaki–Hiyama–Kishi (NHK) macrocyclization for the construction of the highly oxygenated ten‐membered macrocyclic framework. This synthetic route enabled access to another germacranolide congener, tomenphantopin F. Furthermore, cycloisomerization of molephantin into 2‐deethoxy‐2β‐hydroxyphantomolin could be facilitated by irradiation with ultraviolet A light (λmax=370 nm), which opened a versatile and concise access to the related furanogermacranolides such as EM‐2, phantomolin, 2‐O‐demethyltomenphantopin C, and tomenphantopin C.
The preparation of polypropylene microfiber yarns via vortex airflow‐assisted melt differential electrospinning
Authors: Wang Yuhang , Tan Jing , Xu Jinlong , Li Haoyi , Yang Weimin 
Published: March 2024

AbstractPolypropylene (PP) yarn possesses the advantages of low density and exceptional mechanical properties. Through electrospinning, fibers of PP yarns can be refined from 10 to 20 μm to an ultrafine level, thereby acquiring an enlarged specific surface area and more functional sites, expanding its application in high‐value areas. Herein, vortex airflow‐assisted polymer melt differential electrospinning was proposed to fabricate PP microfiber yarns. Under the influence of an electrostatic field, molten PP automatically splits into multiple jets that are further stretched and cooled into ultrafine fibers by suction airflow induced by vortex airflow. Subsequently, multiple ultrafine fibers were twisted into PP yarns using the vortex airflow. The effects of voltage, melt feed speed, and air pressure on the PP electrospun yams formation process as well as the morphology and mechanical properties of both the yarn and fibers were investigated. The results showed that the diameter of PP fibers ranged from 3 to 5 μm. The PP microfiber yams exhibited a relatively high mechanical strength of 1.6 cN/tex under conditions of 56 kV voltage, 0.22 g/min feed rate, and 0.3 MPa air pressure. Finally, the woven fabric made from electrospun PP yams demonstrated higher hydrophobicity compared with fabric woven from commercial PP filaments, suggesting potential applications in waterproof fabrics.
Study on the effect of chain extenders on aliphatic polyurethane and its application
Authors: Ding Wenhe , Liu Hongyan , Bo Yanyan , Zhan Siqi , Yu Zaiqian , Zhang Yuting , Yuan Ruize , Wang Shiwei , Zhang Mingyao 
Published: March 2024

AbstractThermoplastic polyurethane (TPU) has been applied to high‐performance laminated glass depending on its high impact strength and bonding properties. The utilization of various polyurethane molecular structures in laminated glass is scarcely reported. The selection and application of chain extenders are crucial for TPU performance. In this work, aliphatic polyurethane film with high strength has been successfully synthesized, incorporating chain extender of poly(propylene glycol) bis(2‐aminopropyl ether) (PEA230). The films with melting point above 80°C were prepared by adjusting the proportion of dimethylglyoxime (DMG), while simultaneously monitoring the thermal behavior of the samples by DMA. Results indicate that combining PEA230 and DMG in a 1:1 molar ratio yields the hydrogen bonding degree of 85.77%, toughness of 43.14 MJ m3, and shear stress of 1.8 MPa for the polyurethane film. Subsequently, laminated glasses based on the polyurethane film with different thermal properties were constructed successfully, and their super strong impact resistance was confirmed through falling ball impact experiments.
Polyacrylonitrile and polyacrylonitrile/cellulose‐based activated carbon nanofibers obtained from acrylic textile wastes for carbon dioxide capture
Authors: Töngüç Yalçınkaya Tuğçe , Çay Ahmet , Akduman Çiğdem , Akçakoca Kumbasar E. Perrin , Yanık Jale 
Published: March 2024

AbstractThe aim of this study is to develop nanofibrous CO2 adsorbents by using of textile wastes as precursor materials. Therefore, polyacrylonitrile (PAN) and PAN/cell nanofibers were produced from acrylic textile wastes. Nanofibrous membranes were subjected to stabilization, carbonization, and chemical activation processes, respectively, to produce activated carbon nanofiber (ACnF) structures. Elemental analysis, scanning electron microscope, FTIR, and Braunauer, Emmett, and Teller analyses were carried out and CO2 adsorption performance was tested. It was observed that all samples, except PAN/cell nanofibers carbonized at 900°C, preserved their nanofibrous structure. PAN ACnFs had a lower surface area; on the other hand, they were shown to have higher carbon dioxide adsorption values compared with PAN/cell ACnFs. Reasonable adsorption capacities as high as 3.53 and 2.99 mmol/g (at 298 K at a relative pressure of 0.989) were achieved by PAN and PAN/cell ACnFs, respectively. As a result, it was investigated that sustainable ACnF‐based carbon dioxide adsorbents could be produced by the thermochemical processing of electrospun nanofibers obtained from textile wastes.
Synthesis and photo‐initiated radical polymerization of methacrylates derived from bio‐based ω‐hydroxycarboxylic acids
Authors: Heinz Markus , Kepkow Maximilian , Strehmel Bernd , Strehmel Veronika 
Published: March 2024

AbstractThe bio‐based methacrylates 9‐(methacryloyloxy)‐10,18‐dihydroxyoctadecanoic acid/9,18‐dihydroxy‐10‐(methacryloyloxy)octadecanoic acid isomer mixture and 22‐methacryloyloxydocosanoic acid were synthesized from 9,10‐epoxy‐18‐hydroxyoctadecanoic acid and 22‐hydroxydocosanoic acid. The white crystalline 9,10‐epoxy‐18‐hydroxyoctadecanoic acid and cream‐colored 22‐hydroxydocosanoic acid were isolated from both the bark of Betula pendula and cork of Quercus suber after extraction of the milled plant materials with methanol, treating the insoluble residues with 2‐propanole containing suspended sodium hydroxide, application of a working up procedure developed in this work for the resulting mixture, and purification of the products obtained. The new bio‐based methacrylates show higher reactivity in the photoinitiated polymerization in comparison with the commercial laurylmethacrylate as detected by photo‐differential scanning calorimetry (DSC). For comparison, traditional free radical polymerization of the new bio‐based methacrylates was carried out in dimethylsulfoxide using 2,2'‐azobis‐(2‐propionitrile) as initiator. Furthermore, the quantitative conversion of the bio‐based monomers during the photoinitiated polymerization makes these bio‐based monomers interesting for application in coatings. As expected, the photopolymer made from the 9‐(methacryloyloxy)‐10,18‐dihydroxyoctadecanoic acid/9,18‐dihydroxy‐10‐(methacryloyloxy)octadecanoic acid isomer mixture is amorphous. Interestingly, the photopolymer made from the 22‐methacryloyloxydocosanoic acid contains crystalline structures as detected by DSC investigation.
Unraveling florfenicol's effects on splenic histology, erythrocytes, and hematology of healthy Oreochromis niloticus juveniles
Authors: Bardhan Avishek , Abraham Thangapalam J. , Das Ratnapriya , Patil Prasanna K. 
Published: March 2024

AbstractThe study aimed to investigate the impact of administering the antibiotic florfenicol (FFC) through dietary means on Oreochromis niloticus. The experiment involved exposing the fish to FFC at doses 0–10 times the therapeutic dose of 15 mg/kg biomass per day for 10 consecutive days. The group receiving the therapeutic dose showed 100% survival on the 10th day of dosing. Histological analysis revealed dose‐dependent changes in the spleen, including an increase in sinusoidal space, splenic necrosis, white pulp proliferation, splenitis, and red pulp hemorrhages. Additionally, there was an exponential rise in leukocyte counts accompanied by a significant decrease in erythrocyte counts, indicating the development of anemia due to FFC. The observed splenic histological damage, along with increased erythrophagia, erythro‐membrane breakage, and poikilocytosis, highlighted the splenotoxic and hemotoxic effects of FFC at higher doses. Importantly, these toxic effects showed considerable reduction upon discontinuation of FFC dosing. The study emphasized the need to consider FFC‐induced splenotoxic and hemotoxic outcomes in O. niloticus during its application in aquaculture.
Doing more with less: Realistic stereoscopic three‐dimensional anatomical modeling from smartphone photogrammetry
Authors: Morichon Alex , Dannhoff Guillaume , Barantin Laurent , Destrieux Christophe , Maldonado Igor Lima 
Published: March 2024

AbstractTraditional teaching methods struggle to convey three‐dimensional concepts effectively. While 3D virtual models and virtual reality platforms offer a promising approach to teaching anatomy, their cost and specialized equipment pose limitations, especially in disadvantaged areas. A simpler alternative is to use virtual 3D models displayed on regular screens, but they lack immersion, realism, and stereoscopic vision. To address these challenges, we developed an affordable method utilizing smartphone‐based 360° photogrammetry, virtual camera recording, and stereoscopic display (anaglyph or side‐by‐side technique). In this study, we assessed the feasibility of this method by subjecting it to various specimen types: osteological, soft organ, neuroanatomical, regional dissection, and a dedicated 3D‐printed testing phantom. The results demonstrate that the 3D models obtained feature a complete mesh with a high level of detail and a realistic texture. Mesh and texture resolutions were estimated to be approximately 1 and 0.2 mm, respectively. Additionally, stereoscopic animations were both feasible and effective in enhancing depth perception. The simplicity and affordability of this method position it as a technique of choice for creating easily photorealistic anatomical models combined with stereoscopic depth visualization.
A pilot study on gamified and conventional e‐quizzes reinforcing human histology among first‐year medical and physiotherapy students
Authors: Romero‐Alemán María‐del‐Mar 
Published: March 2024

AbstractThe present retrospective, descriptive, and quasi‐experimental study aimed to explore students' perceptions of traditional teaching combined with gamified and nongamified e‐tests for postlecture reinforcement. Midterm knowledge retention and academic performance were also analyzed. The study was conducted from February 2021 to May 2022, involving a single group of first‐year medical and physiotherapy students enrolled in equivalent core subjects on human histology at the University of Las Palmas de Gran Canaria (ULPGC). Lectures were supplemented with gamified Quizizz (QQ) or nongamified Moodle questionnaires (MQ) after lecture (t0) and 30 days later (t30). From 171 attendees, 162 volunteers were surveyed on their perceptions on the experience. Furthermore, 97 volunteers participated in the DOCENTIA‐ULPGC survey on the students' satisfaction, and 123 participants individually answered 20 QQ and 20 MQ. Data were analyzed using the program Jamovi 2.3.24. The survey on volunteers' perception comprised 11 Likert items and 3 numerical scale items. The former showed acceptable internal consistency (ω‐McDonald, 0.70) and validity (KMO, 0.58). Both types of e‐questionnaires facilitated learning and motivated pre‐reading contents but QQs were preferred. Reinforced lectures were rated higher than those unreinforced. Volunteers expressed higher overall satisfaction though DOCENTIA‐ULPGC survey than the prepandemic control group. Average scores peaked at t0 with higher MQ rates. At t30, MQ and QQ scores were acceptable and similar. Participants' outcomes in the final exam tended to improve compared to the prepandemic control group, but without statistical significance. In summary, gamified and nongamified e‐quizzes enhanced the student satisfaction and motivation and facilitated midterm knowledge retention.
An observer‐based composite identifier for online estimation of the Thévenin equivalent parameters of a power system
Authors: Zonetti Daniele , Ortega Romeo , Cisneros Rafael , Bobtsov Alexey , Mancilla‐David Fernando , Gomis‐Bellmunt Oriol 
Published: March 2024

AbstractWe consider a Thévenin equivalent circuit capturing the dynamics of a power grid as seen from the point of common coupling with a power electronic converter and propose a solution to the problem of online identification of the corresponding circuit parameters. For this purpose, we first derive a linear regression model in the conventional abc coordinates that, unfortunately, suffers from severe lack of identifiability properties. In spite of this fact, we design a bounded observer‐based composite identifier that, requiring only local measurements and knowledge of the grid frequency, ensures global boundedness of the parameters estimation error and convergence to a practically small residual set. An extension that guarantees exponential convergence of these errors to zero, in the case that the grid is dominantly inductive, is further provided. The performance of the proposed identifier, which subsumes a conventional gradient descent algorithm, is illustrated via detailed computer simulations.
Managing Drinking Water Aesthetics With Water Safety Planning
Authors: Burlingame Gary A. , Dietrich Andrea M. , Adams Hunter , Bartrand Timothy A. 
Published: March 2024

Key TakeawaysAesthetic water quality is an important but sometimes inadequately addressed aspect of providing a safe and reliable drinking water supply.In the United States, federal regulations provide a starting point for maintaining aesthetic water quality; however, this framework falls short of providing the tools needed to effectively implement the standards.A water safety planning approach can complement regulatory frameworks or be used as an industry standard for better management of aesthetic water quality.
What's New With Old Galvanized Iron Pipe? A Toolbox for Utilities
Authors: Arnold Roger B. , Parks Jeffrey , Edwards Marc A. , Rosenfeldt Becki 
Published: March 2024

Key TakeawaysBecause it can accumulate lead in its scale, galvanized iron pipe (GIP) poses compliance challenges in the Lead and Copper Rule Revisions (LCRR) and proposed Lead and Copper Rule Improvements (LCRI).To prepare for the LCRR/LCRI, utilities can use the GIP corrosion control toolbox outlined here, including targeted sampling, scale analysis, and corrosion control treatment testing.GIP investigation and management can improve water quality, protect public health, and minimize aesthetic discoloration issues.The proposed LCRR/LCRI tap sampling changes mean that GIP could contribute to Action Level exceedances for the first time.
Characterization of AST‐001 non‐clinical pharmacokinetics: A novel selective AKR1C3‐activated prodrug in mice, rats, and cynomolgus monkeys
Authors: Meng Teng , Jung Donald , Cai Xiao‐Hong , Lu Zhao‐Qiang , Yu Ji‐Bing , Qi Tian‐Yang , Meng Fan‐Ying , Ruan Mei‐Zhen , Duan Jian‐Xin 
Published: March 2024

AbstractAST‐001 is a chemically synthesized inactive nitrogen mustard prodrug that is selectively cleaved to a cytotoxic aziridine (AST‐2660) via aldo‐keto reductase family 1 member C3 (AKR1C3). The purpose of this study was to investigate the pharmacokinetics and tissue distribution of the prodrug, AST‐001, and its active metabolite, AST‐2660, in mice, rats, and monkeys. After single and once daily intravenous bolus doses of 1.5, 4.5, and 13.5 mg/kg AST‐001 to Sprague‐Dawley rats and once daily 1 h intravenous infusions of 0.5, 1.5, and 4.5 mg/kg AST‐001 to cynomolgus monkeys, AST‐001 exhibited dose‐dependent pharmacokinetics and reached peak plasma levels at the end of the infusion. No significant accumulation and gender differences were observed after 7 days of repeated dosing. In rats, the half‐life of AST‐001 was dose independent and ranged from 4.89 to 5.75 h. In cynomolgus monkeys, the half‐life of AST‐001 was from 1.66 to 5.56 h and increased with dose. In tissue distribution studies conducted in Sprague‐Dawley rats and in liver cancer PDX models in female athymic nude mice implanted with LI6643 or LI6280 HepG2‐GFP tumor fragments, AST‐001 was extensively distributed to selected tissues. Following a single intravenous dose, AST‐001 was not excreted primarily as the prodrug, AST‐001 or the metabolite AST‐2660 in the urine, feces, and bile. A comprehensive analysis of the preclinical data and inter‐species allometric scaling were used to estimate the pharmacokinetic parameters of AST‐001 in humans and led to the recommendation of a starting dose of 5 mg/m2 in the first‐in‐human dose escalation study.
Aging and brain free cholesterol concentration on amyloid‐β peptide accumulation in guinea pigs
Authors: Pang K. Sandy , Peng H. Benson , Li Betty P. , Wen Binyu , Noh Keumhan , Xia Runyu , Toscan Anja , Serson Sylvia , Fraser Paul E. , Tirona Rommel G. , de Lannoy Inès A. M. 
Published: March 2024

AbstractAlzheimer’s disease is a complex multifactorial neurodegenerative disorder wherein age is a major risk factor. The appropriateness of the Hartley guinea pig (GP), which displays high sequence homologies of its amyloid‐β (Aβ40 and Aβ42) peptides, Mdr1 and APP (amyloid precursor protein) and similarity in lipid handling to humans, was appraised among 9–40 weeks old guinea pigs. Protein expression levels of P‐gp (Abcb1) and Cyp46a1 (24(S)‐hydroxylase) for Aβ40, and Aβ42 efflux and cholesterol metabolism, respectively, were decreased with age, whereas those for Lrp1 (low‐density lipoprotein receptor related protein 1), Rage (receptor for advanced glycation endproducts) for Aβ efflux and influx, respectively, and Abca1 (the ATP binding cassette subfamily A member 1) for cholesterol efflux, were unchanged among the ages examined. There was a strong, negative correlation of the brain Aβ peptide concentrations and Abca1 protein expression levels with free cholesterol. The correlation of Aβ peptide concentrations with Cyp46a1 was, however, not significant, and concentrations of the 24(S)‐hydroxycholesterol metabolite revealed a decreasing trend from 20 weeks old toward 40 weeks old guinea pigs. The composite data suggest a role for free cholesterol on brain Aβ accumulation. The decreases in P‐gp and Lrp1 protein levels should further exacerbate the accumulation of Aβ peptides in guinea pig brain.
MYRF: A unique transmembrane transcription factor‐ from proteolytic self‐processing to its multifaceted roles in animal development
Authors: Qi Yingchuan B. , Xu Zhimin , Shen Shiqian , Wang Zhao , Wang Zhizhi 
Published: March 2024

AbstractThe Myelin Regulator Factor (MYRF) is a master regulator governing myelin formation and maintenance in the central nervous system. The conservation of MYRF across metazoans and its broad tissue expression suggest it has functions extending beyond the well‐established role in myelination. Loss of MYRF results in developmental lethality in both invertebrates and vertebrates, andMYRFhaploinsufficiency in humans causesMYRF‐related Cardiac Urogenital Syndrome, underscoring its importance in animal development; however, these mechanisms are largely unexplored. MYRF, an unconventional transcription factor, begins embedded in the membrane and undergoes intramolecular chaperone mediated trimerization, which triggers self‐cleavage, allowing its N‐terminal segment with an Ig‐fold DNA‐binding domain to enter the nucleus for transcriptional regulation. Recent research suggests developmental regulation of cleavage, yet the mechanisms remain enigmatic. While some parts of MYRF's structure have been elucidated, others remain obscure, leaving questions about how these motifs are linked to its intricate processing and function.