bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary adrenal adult T‐cell leukemia/lymphoma: A case report and review of the literature
Authors: Tomoyose Takeaki , Nagasaki Akitoshi , Uchihara Jun‐Nosuke , Kinjo Shigeko , Sugaya Kimio , Onaga Tomohiro , Ohshima Kouichi , Masuda Masato , Takasu Nobuyuki 
Published: March 2007

AbstractPrimary adrenal lymphoma (PAL) is very rare; the majority of cases reported previously were of B‐cell origin. We report a rare case of primary adrenal adult T‐cell leukemia/lymphoma (primary adrenal ATLL). ATLL is a highly aggressive T‐cell type non‐Hodgkin's lymphoma and etiologically associated with human T‐cell lymphotropic virus 1 (HTLV‐1). Most ATLL patients present with leukemia and widespread lymphadenopathy. A 37‐year‐old Japanese woman presented with back pain in January 2004. Examination showed no peripheral lymphadenopathy, circulating lymphoma cells, hepatosplenomegaly, and skin lesions. Imaging studies demonstrated large adrenal masses bilaterally. Subsequently, she underwent open adrenal biopsy and pathological diagnosis was confirmed as T‐cell lymphoma. The serum antibody to HTLV‐1 was positive. Southern blot analysis detected monoclonal integration of proviral DNA of HTLV‐1 into host genome in the biopsy specimen. The diagnosis of ATLL arising in adrenal glands was established. Despite repeated systemic chemotherapy, the patient died of progressive disease in December 2004. ATLL could primarily involve the adrenal gland and this disease entity should be included in the differential diagnosis of adrenal mass lesions. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.
Cytokine gene polymorphisms in acquired bone marrow failure
Authors: Gidvani Vinod , Ramkissoon Shakti , Sloand Elaine M. , Young Neal S. 
Published: March 2007

AbstractSome acquired aplastic anemia (AA) results from immune‐mediated destruction of hematopoietic stem cells. Cytokine gene polymorphisms are implicated in controlling cytokine production and increasing the susceptibility to some autoimmune diseases. We characterized the IL‐6/‐174, TNF‐α/−308, IL‐10/−1082, IFN‐γ/+874, TGFβ1/−509 single nucleotide polymorphisms (SNP's) and the IL1‐RA second intron variable number tandem repeat (VNTR) alleles in 73 patients with AA and compared the frequency of genotypes to established control populations. We found that some patients with acquired AA have polymorphisms which are linked to high production of proinflammatory cytokines, particularly TNF‐α and IFN‐γ. Am. J. Hematol., 2007. Published 2007 Wiley‐Liss, Inc.
Response to lithium prophylaxis: Interaction between serotonin transporter and BDNF genes
Authors: Rybakowski Janusz K. , Suwalska Aleksandra , Skibinska Maria , Dmitrzak‐Weglarz Monika , Leszczynska‐Rodziewicz Anna , Hauser Joanna 
Published: March 2007

AbstractBoth serotonin transporter and brain‐derived neurotrophic factor (BDNF) genes have been previously implicated in the efficacy of lithium prophylaxis. The aim of the present study was to assess a possible interaction between serotonin transporter genotype (5HTTLPR) and BDNF Val66Met polymorphism, and the prophylactic response to lithium. The study was performed on 111 patients with bipolar mood disorders (43 male, 68 female), aged 30–77 (mean 54 years) who have been treated with lithium carbonate for at least 5 years (5–27 years, mean 15 years). In the group studied, 31 patients (28%) were classified as excellent responders (ER), 54 (49%) as partial responders (PR), and 26 (23%) as non‐responders (NR) to lithium prophylaxis. Age at onset of the illness, duration of illness before treatment introduction and on lithium as well as number of affective episodes before lithium treatment did not differ between these three subgroups of patients. A significant interaction between BDNF and 5HTTLPR polymorphism and lithium response was found. S individuals (patients with s/s or s/l genotype) having Val/Val genotype were significantly more frequent in NR compared with ER or/and PR. Also, S individuals showed extreme differences in response to lithium prophylaxis depending on having either Val/Val or (Val/Met + Met/Met) genotypes of BDNF polymorphism: 9/48 (19%) of ER and 18/48 (37%) of NR in the first group, and 12/30 (40%) and 1/30 (3%) in the second group, respectively. The results obtained may show a significant epistatic interaction between 5‐HTTLPR and BDNF polymorphism, and response to lithium prophylaxis. © 2007 Wiley‐Liss, Inc.
Human Kappa opioid receptor gene (OPRK1) polymorphism is associated with opiate addiction
Authors: Gerra G. , Leonardi C. , Cortese E. , D'Amore A. , Lucchini A. , Strepparola G. , Serio G. , Farina G. , Magnelli F. , Zaimovic A. , Mancini A. , Turci M. , Manfredini M. , Donnini C. 
Published: March 2007

AbstractVariants of the opioid receptors are the obvious candidates underlying addiction. The kappa opioid receptor (KOR) system seems to play a role in stress responsivity, opiate withdrawal and responses to psycho‐stimulants, inhibiting mesolimbic dopamine. KOR gene polymorphisms have been reported to contribute to predisposition to voluntary alcohol‐drinking behavior in experimental animals. In humans, the 36G > T single nucleotide polymorphism (SNP) on KOR gene, that was recently identified, has been found associate with substance dependence, with inconclusive findings. In the present study, 106 heroin addicts (West European, Caucasians) and 70 healthy control subjects matched for race and gender, with no history of substance use disorder, have been genotyped. The frequency of KOR 36G > T SNP was significantly higher among heroin‐dependent individuals compared with control subjects (Fisher's exact = 0.044; Pearsonχ2 = 4.2734,P = 0.039; likelihood ratioχ2tests = 4.6156,P = 0.032). Although KOR silent polymorphisms may apparently have no consequences on mRNA transcription, post‐transcriptional mechanisms, such as mRNA stability, translation efficiency, and regulability may impair the function of kappa receptors system, with increased risk for substance use disorders. In specific, the neurobiological changes induced by mu‐kappa opioid imbalance could underlie vulnerable personality traits and risk behavior. © 2007 Wiley‐Liss, Inc.
Impact of preservation solution on the extent of blood‐air barrier damage and edema formation in experimental lung transplantation
Authors: Mühlfeld Christian , Müller Katharina , Pallesen Lars‐Peder , Sandhaus Tim , Madershahian Navis , Richter Joachim , Wahlers Thorsten , Wittwer Thorsten , Ochs Matthias 
Published: March 2007

AbstractA major aim in lung transplantation is to prevent the loss of structural integrity due to ischemia and reperfusion (I/R) injury. Preservation solutions protect the lung against I/R injury to a variable extent. We compared the influence of two extracellular‐type preservation solutions (Perfadex, or PX, and Celsior, or CE) on the morphological alterations induced by I/R. Pigs were randomly assigned to sham (n = 4), PX (n = 5), or CE (n = 2) group. After flush perfusion with PX or CE, donor lungs were excised and stored for 27 hr at 4°C. The left donor lung was implanted into the recipient, reperfused for 6 hr, and, afterward, prepared for light and electron microscopy. Intra‐alveolar, septal, and peribronchovascular edema as well as the integrity of the blood‐air barrier were determined stereologically. Intra‐alveolar edema was more pronounced in CE (219.80 ± 207.55 ml) than in PX (31.46 ± 15.75 ml). Peribronchovascular (sham: 13.20 ± 4.99 ml; PX: 15.57 ± 5.53 ml; CE: 31.56 ± 5.78 ml) and septal edema (thickness of alveolar septal interstitium, sham: 98 ± 33 nm; PX: 84 ± 8 nm; CE: 249 ± 85 nm) were only found in CE. The blood‐air barrier was similarly well preserved in sham and PX but showed larger areas of swollen and fragmented epithelium or endothelium in CE. The present study shows that Perfadex effectively prevents intra‐alveolar, septal, and peribronchovascular edema formation as well as injury of the blood‐air barrier during I/R. Celsior was not effective in preserving the lung from morphological I/R injury. Anat Rec, 2007. © 2007 Wiley‐Liss, Inc.
Influence of rabeprazole and lansoprazole on the pharmacokinetics of tacrolimus in relation to CYP2C19, CYP3A5 and MDR1 polymorphisms in renal transplant recipients
Authors: Miura Masatomo , Inoue Kazuyuki , Kagaya Hideaki , Satoh Shigeru , Tada Hitoshi , Sagae Yoshinori , Habuchi Tomonori , Suzuki Toshio 
Published: March 2007

AbstractThe objective of this study was to evaluate whether genetic polymorphisms of CYP2C19, CYP3A5 and MDR1 significantly impact the interaction between tacrolimus and rabeprazole or lansoprazole. Seventy‐three recipients were randomly assigned after renal transplantation to receive repeated doses of tacrolimus for 28 days with a regimen of either 20 mg of rabeprazole or 30 mg of lansoprazole. Blood concentrations of tacrolimus were measured by microparticle enzyme immunoassay. The mean daily dose and the dose‐adjusted area under the plasma concentration‐time curves from 0 to 12 h (AUC0–12) of tacrolimus coadministered with rabeprazole or lansoprazole were the lowest and highest, respectively, in CYP2C19 poor metabolizers (PMs) having the CYP3A5*3/*3 genotype (0.084 and 0.112 mg/kg/day and 1.269 and 1.033 ng·h/ml/mg/kg, respectively). On the other hand, the mean dose‐adjusted AUC0−12 of tacrolimus coadministered with rabeprazole or lansoprazole were the highest in CYP2C19 PMs having the MDR13435CC+CT genotype, but not significantly.The present study indicates that there are significant interactions between tacrolimus and rabeprazole or lansoprazole in CYP2C19 PM renal transplant recipients bearing the CYP3A5*3/*3 genotypes. For recipients having these genetic polymorphisms, lower dosages of tacrolimus are required to achieve the target therapeutic index. Copyright © 2007 John Wiley & Sons, Ltd.
Pharmacokinetics of L‐FMAUS, a new antiviral agent, after intravenous and oral administration to rats: contribution of gastrointestinal first‐pass effect to low bioavailability
Authors: Chung Hye J. , Lee Joo H. , Woo Sung J. , Park Hee K. , Koo Chang H. , Lee Myung G. 
Published: March 2007

AbstractThe pharmacokinetics of L‐FMAUS after intravenous and oral administration (20, 50 and 100 mg/kg) to rats, gastrointestinal first‐pass effect of L‐FMAUS (50 mg/kg) in rats, in vitro stability of L‐FMAUS, blood partition of L‐FMAUS between plasma and blood cells of rat blood, and protein binding of L‐FMAUS to 4% human serum albumin were evaluated. L‐FMAUS is being evaluated in a preclinical study as a novel antiviral agent. Although the dose‐normalized AUC values of L‐FMAUS were not significantly different among the three doses after intravenous and oral administration, no trend was apparent between the dose and dose‐normalized AUC. After oral administration of L‐FMAUS (50 mg/kg), approximately 2.37% of the oral dose was not absorbed, and the extent of absolute oral bioavailability (F) was approximately 11.5%. The gastrointestinal first‐pass effect was approximately 85% of the oral dose. The first‐pass effects of L‐FMAUS in the lung, heart and liver were almost negligible, if any, in rats. Hence, the small F of L‐FMAUS in rats was mainly due to the considerable gastrointestinal first‐pass effect. L‐FMAUS was stable in rat gastric juices. The plasma‐to‐blood cells partition ratio of L‐FMAUS was 2.17 in rat blood. The plasma protein binding of L‐FMAUS in rats was 98.6%. Copyright © 2007 John Wiley & Sons, Ltd.
Feasibility of minimally invasive approaches in patients with infected necrotizing pancreatitis
Authors: Besselink M G , van Santvoort H C , Schaapherder A F , van Ramshorst B , van Goor H , Gooszen H G 
Published: March 2007

Abstract

Background
Minimally invasive procedures to treat infected necrotizing pancreatitis (INP) are gaining popularity. The proportion of patients suitable for this approach remains unknown.

Methods
Preoperative computed tomography (CT) scans were reviewed from 106 consecutive patients who had surgery for INP between 2000 and 2003 in 11 Dutch hospitals. Collections related to the pancreas were classified according to their distance from the left abdominal wall. Five radiologists judged ‘accessibility’ for drain placement and the likelihood that there was a fluid component that would drain (‘drainability’). Agreement between radiologists was determined.

Results
CT scans of 80 (75 per cent) patients were available (59 men; age range 29–80 years). The median interval between hospital admission and preoperative CT scan was 20 days. In 55 (69 per cent) patients, the lateral border of the collection was less than 5 cm from the left abdominal wall. Placement of a drain was deemed feasible in 67 (84 (range 77–89) per cent) patients; mean(s.d.) kappa 0·428(0·096). In 45 (56 per cent) patients, a drain could be placed through the left retroperitoneum. In 43 (54 (range 49–82) per cent) patients, collections were judged to contain a drainable fluid component. Interobserver agreement on ‘drainability’ was poor, mean(s.d.) kappa 0·289(0·101).

Conclusion
Most peripancreatic collections in INP were considered accessible to a minimally invasive approach.
Comparison of breast cancer mortality rates with those of ovarian and colorectal carcinoma
Authors: Stearns A T , Hole D , George W D , Kingsmore D B 
Published: March 2007

Abstract

Background
Traditional survival curves cannot easily be used to predict outcome for an individual patient on a year-to-year basis. This difficulty is partly overcome by yearly mortality analysis. This method was employed to analyse long-term follow-up of three cancers: colorectal, ovarian and breast cancer.

Methods
The study used prospectively collected cancer registry data from geographically defined regions in Scotland. Cohort sizes were 7196 patients with breast cancer, 3200 with colorectal cancer and 1866 with ovarian cancer. Follow-up extended to 23 years.

Results
Two distinct patterns of mortality emerged. Mortality rates for ovarian and colorectal cancer were initially high (41 and 21 per cent) but decreased rapidly; by 10 years patients had either died or were cured. The influence of stage diminished with follow-up. Breast cancer mortality was lower than that of colorectal or ovarian cancer, but remained raised in comparison to the general population throughout follow-up. The influence of breast cancer size reduced with follow-up, whereas that of nodal status persisted.

Conclusion
Patients with breast cancer live at increased risk of death to the end of follow-up, supporting the concept of dormancy in breast cancer biology. This was not observed with colorectal or ovarian cancer.
Anatomical and radiological evidence for the iliolumbar vein as an inferior lumbar venous system
Authors: Hamid M. , Toussaint P.J. , Delmas V. , Gillot C. , Coutaux A. , Plaisant O. 
Published: March 2007

AbstractThe purpose of this work was to study an inferior lumbar venous system, which turned out to be the vertical component of the iliolumbar vein as defined in early works by Bourgery and Jacob, though there is a terminological ambiguity between the iliolumbar vein and the ascending lumbar vein in the literature. However, the iliolumbar vein is most commonly defined as a vein draining the fourth and fifth lumbar vertebral segments. Cadaver studies, including one injection‐corrosion, and in vivo venograms were analyzed by visual inspection and measurements. Whether the injection was made via the axillary or the saphenous veins, the inferior lumbar vein was always filled, demonstrating that it is part of the vertebral venous system. An interruption or a plexiform shape of the venous system at the level of the third lumbar vertebra, and an increase in caliber as this vein runs downwards, allowed differentiating the inferior lumbar vein from the ascending lumbar vein. The inferior lumbar vein and the superior iliac vein drained into the iliac veins, either external or internal iliac vein, but typically into the common iliac vein, separately or with a single common trunk. This common trunk was observed in 92% of the dissected cases on the right side and in 46% on the left, whereas it was seen in 50% of the radiological studies on the right side and 52% on the left. Consequently, the inferior lumbar vein was the main component of the iliolumbar vein, and as such should be differentiated from the ascending lumbar vein. Clin. Anat. 20:545–552, 2007. © 2007 Wiley‐Liss, Inc.
Intensive treatment of hypertension decreases the risk of hyperperfusion and intracerebral hemorrhage following carotid artery stenting
Authors: Abou‐Chebl Alex , Reginelli Joel , Bajzer Chris T. , Yadav Jay S. 
Published: March 2007

AbstractObjectives: To assess the efficacy of a comprehensive blood pressure (BP) management protocol in reducing intracerebral hemorrhage (ICH) following carotid artery stenting (CAS). Background: Following CAS hyperperfusion syndrome (HPS) can lead to significant morbidity and mortality. Hypertension plays an essential role in its development. Methods:We instituted a comprehensive BP protocol following the last case of ICH complicating a CAS procedure. All patients received comprehensive monitoring of BP and treatment to a BP < 140/90 mm Hg; those with a treated stenosis ≥90%, contralateral stenosis ≥80%, and hypertension (i.e., risk factors for HPS) were treated to a BP < 120/80 mm Hg. Patients who developed HPS received parenteral β‐blockers or nitrates titrated to resolution of symptoms and discharged when asymptomatic and normotensive. Patients and families were instructed to measure BP twice daily for 2 weeks and to call if hypertension or headache developed. Results: A total of 836 patients had CAS, 266 prior to the comprehensive BP management program and 570 subsequently. The incidence of HPS/ICH was 5/266 (1.9%) patients prior to comprehensive BP management and 3/570 (0.5%) patients afterwards, P = 0.12. The incidence of ICH was 3/266 (1.1%) and 0/570, respectively, P = 0.032. In high‐risk patients both HPS and ICH were significantly reduced from 29.4 to 4.2% (P = 0.006) and 17.6–0% (P = 0.006), respectively. There were no complications attributable to the comprehensive program and lengths of hospitalization were similar (2.6 vs. 2.1 days, P = 0.18). Conclusions: Comprehensive management of arterial hypertension can lower the incidence of ICH and HPS in high‐risk patients following CAS, without additional complications or prolonged hospitalizations. © 2007 Wiley‐Liss, Inc.
Bifurcation stenting with a dedicated biolimus‐eluting stent: X‐ray visual enhancement of the final angiographic result with “stentboost subtract”
Authors: Agostoni Pierfrancesco , Verheye Stefan 
Published: March 2007

AbstractA 51 year‐old man underwent percutaneous coronary intervention of a significant “true” bifurcation lesion involving the proximal left anterior descendens (LAD) artery and an important first diagonal branch with a dedicated bifurcation stent, which is a conical self‐expandable biolimus‐eluting stent with a “flared” distal part allowing for optimal scaffolding of the carina of the bifurcation, and two additional sirolimus‐eluting stents, deployed with the V‐stenting technique, one in the LAD and one in the diagonal branch, in overlap with the distal part of the “flared” biolimus‐eluting stent. An X‐ray enhancing visualization technique, “StentBoost Subtract,” was used to obtain an improved visualization of the stent in relation to the corresponding vessel lumen and revealed good expansion of all the stents and good apposition to the vessel wall. © 2007 Wiley‐Liss, Inc.
Computed tomography coronary angiographic demonstration of a single coronary artery with the right coronary artery arising as a continuation from the left circumflex coronary artery
Authors: Berbarie Rafic F. , Anderson Amy S. , Schussler Jeffrey M. 
Published: March 2007

AbstractWe present the case of a 31‐year‐old man undergoing a chest pain evaluation. This report illustrates how 64‐slice computed tomographic coronary angiography (CTCA) can aid in the management of patients with equivocal stress test results. It also describes how CTCA can accurately determine the origin and course of an anomalous coronary artery. © 2007 Wiley‐Liss, Inc.
Radiofrequency perforation of the right ventricular outflow tract as a palliative strategy for pulmonary atresia with ventricular septal defect
Authors: Walsh Mark A. , Lee Kyong‐Jin , Chaturvedi Rajiv , Van Arsdell Glen S. , Benson Lee N. 
Published: March 2007

AbstractBackground:Radiofrequency perforation (RF) of the right ventricular outflow tract (RVOT), while an effective management strategy in children with an intact ventricular septum, has not been fully detailed in those presenting with a ventricular septal defect.Objective:To determine whether transcatheter perforation of the atretic pulmonary valve is an acceptable management strategy prior to surgical repair.Results:Valve perforation was attempted in eight children seen between May 2000 and March 2006, five being infants between 1 and 9 days of age. In five children, this was the first of two procedures, the second a planned surgical correction. The RF was successful in six children with one child requiring additional stenting of the RVOT. Of these children, three attained a biventricular repair within the next year without additional palliative surgical procedures. Of the remaining three patients, one is awaiting surgical correction, one did not require further surgery, and one had this procedure as the only planned palliation. The two children in whom RF was not possible were referred for surgical augmentation of pulmonary blood flow.Conclusion:A treatment strategy that includes pulmonary valve perforation as initial palliation to increase pulmonary blood flow may be effective. Additional experience to better define those children who would benefit from this treatment algorithm is required. © 2007 Wiley‐Liss, Inc.
Selective Hydrogenation of Citral in an Organic Solvent, in a Ionic Liquid, and in Substance
Authors: Steffan M. , Lucas M. , Brandner A. , Wollny M. , Oldenburg N. , Claus P. 
Published: March 2007

AbstractIt is investigated whether the catalyst system Ag‐In/SiO2 can be applied in the selective hydrogenation of citral, with the aim of synthesizing the acyclic, allylic terpene alcohols geraniol/nerol with high selectivity and space‐time yield. In addition, as liquid‐phase hydrogenations are often also influenced by the choice of solvent, it is of interest to know how the solvent, in particular in terms of its polarity and hydrogen solubility, affects the activity and the selectivity of catalysts during hydrogenation of the α,β‐unsaturated aldehyde citral.
Macrokinetic Study of the Electrochemical Synthesis Process of Sodium Dichromate
Authors: Li C. W. , Qi T. , Wang F. A. , Zhang Y. , Chen G. S. , Zhang P. 
Published: March 2007

AbstractIn order to address the problems existing in the traditional production techniques for sodium dichromate, a new green technology for producing sodium dichromate using an electrochemical synthesis method was studied. Using a self‐made electrosynthesis reactor composed of pure titanium and stainless steel, with a multiple‐unit metal oxide combination anode, a stainless steel cathode, and a reinforcing combination cation exchange membrane, the kinetic experiments were carried out on the direct electrochemical synthesis reaction of sodium dichromate from sodium chromate. The kinetic data were experimentally measured at different temperatures and different initial sodium chromate concentrations of anolyte. The results show that the electrochemical synthesis process presents complicated zero‐order reaction kinetic characteristics, with the reaction rate constant depending on the initial sodium chromate concentration. The macrokinetic equation of the electrochemical synthesis reaction was established, and some kinetic parameters were calculated. The apparent activation energy is less than that of the ordinary chemical reaction, and this shows that the electrochemical synthesis of sodium dichromate has great development potential.