bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theology and the Lure of the Practical: An Overview
Authors: McClintock Fulkerson Mary 
Published: February 2007

AbstractCurrent trends in practical theology are found both within and outside of the typical divisions of theological education into the four fields of biblical studies, church history, systematic theology/ethics, and the so‐called ‘practical fields’. Although this fourth area was initially confined to ministerial/clerical practices, attention to the full complexities of lived faith have compelled developments that transcend that limiting definition, even if the constraints of that structure have not entirely disappeared. Movement from pastoral care as psychological treatment of individuals to its wider framing through contextual‐political understandings illustrates the impact of critical social theory and liberation theologies. Interest in philosophical accounts of phronesis and bodily habitus that overcome the split between belief and practice shape and expand what counts as work in systematic theology. Continuing debates include the degree to which dynamics of power through political and global forces must be factored into lived faith and the desire to protect Christian identity versus appropriating knowledges from other ‘sciences’ of the human. Developments in religious studies on lived religion expand the complexity of the category practice and challenge traditional categories in theological education.
THE GEOMETRY OF QUADRATIC DIFFERENTIAL SYSTEMS WITH A WEAK FOCUS OF SECOND ORDER
Authors: ARTÉS JOAN C. , LLIBRE JAUME , SCHLOMIUK DANA 
Published: February 2007

Planar quadratic differential systems occur in many areas of applied mathematics. Although more than one thousand papers were written on these systems, a complete understanding of this class is still missing. Classical problems, and in particular, Hilbert's 16th problem [Hilbert, 1900, 1902], are still open for this class. In this article we make an interdisciplinary global study of the subclass [Formula: see text] which is the closure within real quadratic differential systems, of the family QW2 of all such systems which have a weak focus of second order. This class [Formula: see text] also includes the family of all quadratic differential systems possessing a weak focus of third order and topological equivalents of all quadratic systems with a center.The bifurcation diagram for this class, done in the adequate parameter space which is the three-dimensional real projective space, is quite rich in its complexity and yields 373 subsets with 126 phase portraits for [Formula: see text], 95 for QW2, 20 having limit cycles but only three with the maximum number of limit cycles (two) within this class. The phase portraits are always represented in the Poincaré disc. The bifurcation set is formed by an algebraic set of bifurcations of singularities, finite or infinite and by a set of points which we suspect to be analytic corresponding to global separatrices which have connections.Algebraic invariants were needed to construct the algebraic part of the bifurcation set, symbolic computations to deal with some quite complex invariants and numerical calculations to determine the position of the analytic bifurcation set of connections.The global geometry of this class [Formula: see text] reveals interesting bifurcations phenomena; for example, all phase portraits with limit cycles in this class can be produced by perturbations of symmetric (reversible) quadratic systems with a center. Many other nonlinear phenomena displayed here form material for further studies.
Statistical Parameterization of Heterogeneous Oceanic Convection
Authors: Pasquero Claudia , Tziperman Eli 
Published: February 2007

Abstract
A statistical convective adjustment scheme is proposed that attempts to account for the effects of mesoscale and submesoscale variability of temperature and salinity typically observed in the oceanic convective regions. Temperature and salinity in each model grid box are defined in terms of their mean, variance, and mutual correlations. Subgrid-scale instabilities lead to partial mixing between different layers in the water column. This allows for a smooth transition between the only two states (convection on and convection off) allowed in standard convective adjustment schemes. The advantage of the statistical parameterization is that possible instabilities associated with the sharp transition between the two states, which are known to occasionally affect the large-scale model solution, are eliminated. The procedure also predicts the generation of correlations between temperature and salinity and the presence of convectively induced upgradient fluxes that have been obtained in numerical simulations of heterogeneous convection and that cannot be represented by standard convective adjustment schemes.
Regional Dynamic and Steric Sea Level Change in Response to the IPCC-A1B Scenario
Authors: Landerer Felix W. , Jungclaus Johann H. , Marotzke Jochem 
Published: February 2007

AbstractThis paper analyzes regional sea level changes in a climate change simulation using the Max Planck Institute for Meteorology (MPI) coupled atmosphere–ocean general circulation model ECHAM5/MPI-OM. The climate change scenario builds on observed atmospheric greenhouse gas (GHG) concentrations from 1860 to 2000, followed by the International Panel on Climate Change (IPCC) A1B climate change scenario until 2100; from 2100 to 2199, GHG concentrations are fixed at the 2100 level. As compared with the unperturbed control climate, global sea level rises 0.26 m by 2100, and 0.56 m by 2199 through steric expansion; eustatic changes are not included in this simulation. The model’s sea level evolves substantially differently among ocean basins. Sea level rise is strongest in the Arctic Ocean, from enhanced freshwater input from precipitation and continental runoff, and weakest in the Southern Ocean, because of compensation of steric changes through dynamic sea surface height (SSH) adjustments. In the North Atlantic Ocean (NA), a complex tripole SSH pattern across the subtropical to subpolar gyre front evolves, which is consistent with a northward shift of the NA current. On interannual to decadal time scales, the SSH difference between Bermuda and the Labrador Sea correlates highly with the combined baroclinic gyre transport in the NA but only weakly with the meridional overturning circulation (MOC) and, thus, does not allow for estimates of the MOC on these time scales. Bottom pressure increases over shelf areas by up to 0.45 m (water column equivalent) and decreases over the Atlantic section in the Southern Ocean by up to 0.20 m. The separate evaluation of thermosteric and halosteric sea level changes shows that thermosteric anomalies are positive over most of the World Ocean. Because of increased atmospheric moisture transport from low to high latitudes, halosteric anomalies are negative in the subtropical NA and partly compensate thermosteric anomalies, but are positive in the Arctic Ocean and add to thermosteric anomalies. The vertical distribution of thermosteric and halosteric anomalies is highly nonuniform among ocean basins, reaching deeper than 3000 m in the Southern Ocean, down to 2200 m in the North Atlantic, and only to depths of 500 m in the Pacific Ocean by the end of the twenty-first century.
Identification of feigned maximal shoulder external rotation effort
Authors: Chaler Joaquim , Dvir Zeevi , Díaz Urko , Quintana Salvador , Abril Àngels , Unyó Carme , Garreta Roser 
Published: February 2007

Objective: To examine the efficiency of the difference between the isokinetic eccentric to concentric strength ratios at high and low velocities (DEC) for identifying feigned maximal shoulder external rotation effort. Background: Previous studies have indicated that the DEC is a powerful identifier of feigned maximal effort. However comparison of maximal versus feigned maximal shoulder external rotation effort has not been undertaken. Due to the high prevalence of rotational shoulder disorders and their chronic ramifications in terms of occupational disability such a study is of specific interest. Design: Maximal and feigned maximal shoulder external rotation isokinetic efforts were compared. Setting: Functional evaluation unit at an occupational rehabilitation centre. Subjects: Seventeen healthy male volunteers aged between 20 and 40 years old. Main measure: Concentric and eccentric isokinetic tests at 30°/s and 120°/s in maximal and feigned maximal experimental conditions. DEC was calculated by subtracting the 30°/s eccentric/concentric peak torque ratios from the 120°/s ones for both experimental conditions. Results: A case-by-case analysis revealed that the DEC scores derived from the feigned effort were significantly greater than their maximal counterparts in all cases, leading to a cut-off value (0.81) which could distinguish between maximal and feigned performances. Conclusions: The findings indicate that the DEC is highly effective in identifying feigned shoulder external rotation effort in normal subjects.
Perceptions of self-efficacy and rehabilitation among neurologically disabled adults
Authors: Dixon Guy , Thornton Everard W , Young Carolyn A 
Published: February 2007

Objective: To explore constructs relevant to self-efficacy in neurological rehabilitation. Design: Qualitative methods using semi-structured interviews. Setting: Specialist neurological rehabilitation unit, Liverpool, UK. Subjects: Twenty-four patients (12 male) with experience of inpatient rehabilitation, aged 17-59 (mean 38.1) years at onset, with diagnoses of stroke ( n = 8), traumatic brain injury ( n = 6) or other monophasic neurological impairment ( n = 10). Results: Eleven themes emerged from the data that reflect self-efficacy beliefs: self-reliance and independence were deemed important and many patients recognized the importance of determination, making time to take an active role and working in partnership with the multidisciplinary team. Patients had complex information needs but were able to use goal setting and the vicarious experiences of other inpatients to map out the stages of their own recovery. It was important for patients to be able to recognize for themselves that they were making progress and they valued external reassurance on this from other patients, staff and visitors. A number of difficulties were identified that interfered with their developing self-efficacy in rehabilitation, such as structuring their time. Two different models for rehabilitation emerged from the data, ‘recovery’ and ‘adaptation’. Conclusions: Patients consistently identified 11 factors falling in the supraordinate themes of self, others and process, and these influenced their self-efficacy to participate in neurological rehabilitation. Patients consider rehabilitation in terms of either an ‘adaptation’ or ‘recovery’ model.
Antitumor effects of HSV-TK–engineered donor lymphocytes after allogeneic stem-cell transplantation
Authors: Ciceri Fabio , Bonini Chiara , Marktel Sarah , Zappone Elisabetta , Servida Paolo , Bernardi Massimo , Pescarollo Alessandra , Bondanza Attilio , Peccatori Jacopo , Rossini Silvano , Magnani Zulma , Salomoni Monica , Benati Claudia , Ponzoni Maurilio , Callegaro Luciano , Corradini Paolo , Bregni Marco , Traversari Catia , Bordignon Claudio 
Published: February 2007

Abstract
The extensive exploitation of the antitumor effect of donor lymphocytes infused after allogeneic hematopoietic stem-cell transplantation (allo-HSCT) is limited by the risk of graft-versus-host disease (GvHD). To overcome this limitation, we investigated the therapeutic potential of donor lymphocytes engineered with the suicide gene thymidine kinase of herpes simplex virus (TK) in 23 patients experiencing recurrence of hematologic malignancies after allo-HSCT. Long-term follow-up of infused patients included analysis of engraftment of genetically engineered lymphocytes, in vivo assessment of antitumor effect, and control of GvHD by ganciclovir. All 17 patients evaluable for engraftment and graft-versus-leukemia (GvL) had circulating TK+ cells detectable beginning at a median time of 18 days. Eleven patients (65%) experienced a substantial clinical benefit resulting in 6 (35%) complete remissions and 5 (29%) partial responses. The antitumor effect tightly correlated with the in vivo expansion of TK+ cells. Seven patients received ganciclovir, resulting in elimination of TK+ cells and effective and selective treatment of GvHD. Immunization against HSV-TK was observed in 7 patients but did not preclude an effective GvL. These data validate the feasibility, safety, and efficacy of TK+ cells in the context of allografting and represent the basis for a broader application of this technology.
CD4 cells can be more efficient at tumor rejection than CD8 cells
Authors: Perez-Diez Ainhoa , Joncker Nathalie T. , Choi Kyungho , Chan William F. N. , Anderson Colin C. , Lantz Olivier , Matzinger Polly 
Published: February 2007

AbstractResearchers designing antitumor treatments have long focused on eliciting tumor-specific CD8 cytotoxic T lymphocytes (CTL) because of their potent killing activity and their ability to reject transplanted organs. The resulting treatments, however, have generally been surprisingly poor at inducing complete tumor rejection, both in experimental models and in the clinic. Although a few scattered studies suggested that CD4 T “helper” cells might also serve as antitumor effectors, they have generally been studied mostly for their ability to enhance the activity of CTL. In this mouse study, we compared monoclonal populations of tumor-specific CD4 and CD8 T cells as effectors against several different tumors, and found that CD4 T cells eliminated tumors that were resistant to CD8-mediated rejection, even in cases where the tumors expressed major histocompatibility complex (MHC) class I molecules but not MHC class II. MHC class II expression on host tissues was critical, suggesting that the CD4 T cells act indirectly. Indeed, the CD4 T cells partnered with NK cells to obtain the maximal antitumor effect. These findings suggest that CD4 T cells can be powerful antitumor effector cells that can, in some cases, outperform CD8 T cells, which are the current “gold standard” effector cell in tumor immunotherapy.
Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist
Authors: Jenkins Julian M. , Williams Daphne , Deng Yanli , Uhl Joanne , Kitchen Valerie , Collins David , Erickson-Miller Connie L. 
Published: February 2007

AbstractEltrombopag (SB-497 115) is a first-in-class, oral, small-molecule, nonpeptide agonist of the thrombopoietin receptor (TpoR), being developed as a treatment for thrombocytopenia of various etiologies. In this phase 1 placebo-controlled clinical trial in 73 healthy male subjects, eltrombopag was administered as once-daily oral capsules for 10 days at doses of 5, 10, 25, 30, 50, and 75 mg. The pharmacokinetics of eltrombopag were dose dependent and linear, and eltrombopag increased platelet counts in a dose-dependent manner. There were no apparent differences in the incidence or severity of adverse events in subjects receiving active or placebo study medication. These observations indicate that eltrombopag is a once-daily, oral TpoR agonist with demonstrated thrombopoietic activity in human subjects, encouraging further studies in patients with thrombocytopenia.
Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival
Authors: Cerhan James R. , Wang Sophia , Maurer Matthew J. , Ansell Stephen M. , Geyer Susan M. , Cozen Wendy , Morton Lindsay M. , Davis Scott , Severson Richard K. , Rothman Nathaniel , Lynch Charles F. , Wacholder Sholom , Chanock Stephen J. , Habermann Thomas M. , Hartge Patricia 
Published: February 2007

AbstractRecent gene-expression data have suggested that host immune genetic signatures may predict outcomes in patients with follicular lymphoma. We evaluated the hypothesis that germ line common variation in candidate immune genes is associated with survival. Cox models were used to estimate hazard ratios (HR) and corresponding 95% confidence intervals for individual SNPs after accounting for age, clinical, and other demographic factors. The median age at diagnosis of the 278 patients was 57 years, and 59 (21%) of the patients died during follow-up, with a median follow-up of 59 months (range, 27-78 months) for surviving patients. SNPs in IL8 (rs4073; HRTT = 2.14, 1.26-3.63), IL2 (rs2069762; HRGT/TT = 1.80, 1.06-3.05), IL12B (rs3212227; HRAC/CC = 1.83, 1.06-3.06), and IL1RN (rs454078; HRAA = 1.93, 1.11-3.34) were the most robust predictors of survival. A summary score of the number of deleterious genotypes from these genes was strongly associated with survival (P = .001). A risk score that combined the 4 SNPs with the clinical and demographic factors was even more strongly associated with survival (P < .001); the 5-year Kaplan-Meier survival estimates were 96% (93%-100%), 72% (62%-83%), and 58% (48%-72%) for groups at low, intermediate, and high risk, respectively. Common variation in host immune genes warrants further evaluation as a promising class of prognostic factors in follicular lymphoma.
Dynamic regulation of Gata factor levels is more important than their identity
Authors: Ferreira Rita , Wai Albert , Shimizu Ritsuko , Gillemans Nynke , Rottier Robbert , von Lindern Marieke , Ohneda Kinuko , Grosveld Frank , Yamamoto Masayuki , Philipsen Sjaak 
Published: February 2007

AbstractThree Gata transcription factors (Gata1, -2, and -3) are essential for hematopoiesis. These factors are thought to play distinct roles because they do not functionally replace each other. For instance, Gata2 messenger RNA (mRNA) expression is highly elevated in Gata1-null erythroid cells, yet this does not rescue the defect. Here, we test whether Gata2 and -3 transgenes rescue the erythroid defect of Gata1-null mice, if expressed in the appropriate spatiotemporal pattern. Gata1, -2, and -3 transgenes driven by β-globin regulatory elements, directing expression to late stages of differentiation, fail to rescue erythropoiesis in Gata1-null mutants. In contrast, when controlled by Gata1 regulatory elements, directing expression to the early stages of differentiation, Gata1, -2, and -3 do rescue the Gata1-null phenotype. The dramatic increase of endogenous Gata2 mRNA in Gata1-null progenitors is not reflected in Gata2 protein levels, invoking translational regulation. Our data show that the dynamic spatiotemporal regulation of Gata factor levels is more important than their identity and provide a paradigm for developmental control mechanisms that are hard-wired in cis-regulatory elements.
In vivo vasculogenic potential of human blood-derived endothelial progenitor cells
Authors: Melero-Martin Juan M. , Khan Zia A. , Picard Arnaud , Wu Xiao , Paruchuri Sailaja , Bischoff Joyce 
Published: February 2007

Abstract
Vascularization of tissues is a major challenge of tissue engineering (TE). We hypothesize that blood-derived endothelial progenitor cells (EPCs) have the required proliferative and vasculogenic activity to create vascular networks in vivo. To test this, EPCs isolated from human umbilical cord blood or from adult peripheral blood, and human saphenous vein smooth muscle cells (HSVSMCs) as a source of perivascular cells, were combined in Matrigel and implanted subcutaneously into immunodeficient mice. Evaluation of implants at one week revealed an extensive network of human-specific lumenal structures containing erythrocytes, indicating formation of functional anastomoses with the host vasculature. Quantitative analyses showed the microvessel density was significantly superior to that generated by human dermal microvascular endothelial cells (HDMECs) but similar to that generated by human umbilical vein endothelial cells (HUVECs). We also found that as EPCs were expanded in culture, their morphology, growth kinetics, and proliferative responses toward angiogenic factors progressively resembled those of HDMECs, indicating a process of in vitro maturation. This maturation correlated with a decrease in the degree of vascularization in vivo, which could be compensated for by increasing the number of EPCs seeded into the implants. Our findings strongly support the use of human EPCs to form vascular networks in engineered organs and tissues.
Tools used to measure airway remodelling in research
Authors: Bergeron C. , Tulic M. K. , Hamid Q. 
Published: February 2007

Airway remodelling refers to changes in the airway structure and includes subepithelial fibrosis, increased smooth muscle mass, submucosal gland enlargement, neovascularisation and epithelial alterations. Remodelling is observed in response to chronic injury and is seen not only in asthma but in all airway diseases.Remodelling is associated with more severe airflow obstruction and airway hyperresponsiveness in asthma; however, the clinical significance of this is still a matter of debate. Research should be pursued to better understand the accurate implication of airway remodelling in disease and its therapeutic modulation.To allow research in this field, accurate and standardised methods should be utilised to measure airway alterations in disease and following therapy. The standard detection of structural alterations is through direct analyses of airway tissues obtained during apost mortem, surgically or by flexible bronchoscopy. To avoid invasive techniques, other tools have been developed to indirectly measure remodelling, including induced sputum, bronchoalveolar lavage fluid, blood and urine analyses, physiological and radiological assessments, as well asin vitrotechniques.Although of great interest, the exact significance of airway remodelling measurements gained through such indirect techniques is uncertain and further research is needed. Despite their invasive nature, direct methods should be favoured to adequately measure airway remodelling in disease and its modulation by therapy.
1α,25-Dihydroxycholecalciferol activates binding of CREB to a CRE site in theCD14promoter and drives promoter activity in a phosphatidylinositol-3 kinase-dependent manner
Authors: Moeenrezakhanlou Alireza , Nandan Devki , Shephard Lindsay , Reiner Neil E 
Published: February 2007

Abstract1,25-Dihydroxycholecalciferol, also known as 1α,25-dihydroxyvitamin D3 or calcitriol, regulates the differentiation and functional properties of mononuclear phagocytes. Many of these effects involve nongenomic signaling pathways, which are not fully understood. Activation of CD14 expression, a monocyte differentiation marker and coreceptor with TLR-2 for bacterial LPS, by calcitriol was shown previously to be PI-3K-dependent [1]; however, the mechanism of gene activation remained undefined. Using a transcription factor-binding array screen coupled with EMSA, we found evidence for PI-3K-dependent activation of CREB in THP-1 cells incubated with calcitriol. Furthermore, analysis of the proximal promoter of human CD14 identified regions that contained up to seven sequences, which showed significant similarity to a canonical CRE sequence, 5′-TGACGTCA-3′. Treatment of THP-1 cells with calcitriol activated CREB binding to one of these regions at Positions −37 to −55, relative to the transcription start site in a PI-3K-dependent manner. This 19-mer region also became transcriptionally active in a reporter assay in response to calcitriol, again dependent on PI-3K. Mutation of the CRE within the 19-mer abolished this activity. Taken together, these results show that calcitriol signaling, leading to activation of the CD14 promoter, involves CREB activation downstream of PI-3K.