bluuebunny/crossref_metadata_2025_split huggingface dataset:
REMARKS ON CONTEXT-FREE PARALLEL COMMUNICATING GRAMMAR SYSTEMS GENERATING CROSSED AGREEMENTS
Authors: TRUTHE BIANCA 
Published: August 2008

Parallel communicating grammar systems are language generating devices consisting of several grammars which derive synchronously their sentential forms and communicate with each other by sending their sentential forms to another component on request. Due to collaboration, grammar systems with context-free components are more powerful than a single context-free grammar; they even can generate all recursively enumerable languages. In natural languages, there occur constructions that cannot be modelled by context-free languages. Three important phenomena are the so-called multiple agreements, crossed agreements and replication which are represented by the three non-context-free languages K1 = { anbncn | n ≥ 1 }, K2 = { anbmcndm | m ≥ 1, n ≥ 1 }, and K3 = { ww | w ∈ { a, b }+}, respectively. In the present paper, we give parallel communicating grammar systems (PC grammar systems) that are context-free and that generate the language K2, working in different modes. In two cases, the results are optimal.
STOCHASTIC DYNAMICS OF VISCOELASTIC SKEINS: CONDENSATION WAVES AND CONTINUUM LIMITS
Authors: ALBEVERIO SERGIO , ALT WOLFGANG 
Published: August 2008

Skeins (one-dimensional queues) of migrating birds show typical fluctuations in swarm length and frequent events of "condensation waves" starting at the leading bird and traveling backward within the moving skein, similar to queuing traffic waves in car files but more smooth. These dynamical phenomena can be fairly reproduced by stochastic ordinary differential equations for a "multi-particle" system including the individual tendency of birds to attain a preferred speed as well as mutual interaction "forces" between neighbors, induced by distance-dependent attraction or repulsion as well as adjustment of velocities. Such a one-dimensional system constitutes a so-called "stochastic viscoelastic skein." For the simple case of nearest neighbor interactions we define the density between individualsu = u(t, x) as a step function inversely proportional to the neighbor distance, and the velocity function v = v(t, x) as a standard piecewise linear interpolation between individual velocities. Then, in the limit of infinitely many birds in a skein of finite length, with mean neighbor distance δ converging to zero and after a suitable scaling, we obtain continuum mass and force balance equations that constitute generalized nonlinear compressible Navier–Stokes equations. The resulting density-dependent stress functions and viscosity coefficients are directly derived from the parameter functions in the original model. We investigate two different sources of additive noise in the force balance equations: (1) independent stochastic accelerations of each bird and (2) exogenous stochastic noise arising from pressure perturbations in the interspace between them. Proper scaling of these noise terms leads, under suitable modeling assumptions, to their maintenance in the continuum limit δ → 0, where they appear as (1) uncorrelated spatiotemporal Gaussian noise or, respectively, (2) certain spatially correlated stochastic integrals. In both cases some a priori estimates are given which support convergence to the resulting stochastic Navier–Stokes system. Natural conditions at the moving swarm boundaries (along characteristics of the hyperbolic system) appear as singularly perturbed zero-tension Neumann conditions for the velocity function v. Numerical solutions of this free boundary value problem are compared to multi-particle simulations of the original discrete system. By analyzing its linearization around the constant swarm state, we can characterize several properties of swarm dynamics. In particular, we compute approximating values for the averaged speed and length of typical condensation waves.
Sensitivity of Hybrid ENSO Models to Unresolved Atmospheric Variability
Authors: Zavala-Garay J. , Zhang C. , Moore A. M. , Wittenberg A. T. , Harrison M. J. , Rosati A. , Vialard Jérôme , Kleeman R. 
Published: August 2008

AbstractA common practice in the design of forecast models for ENSO is to couple ocean general circulation models to simple atmospheric models. Therefore, by construction these models (known as hybrid ENSO models) do not resolve various kinds of atmospheric variability [e.g., the Madden–Julian oscillation (MJO) and westerly wind bursts] that are often regarded as “unwanted noise.” In this work the sensitivity of three hybrid ENSO models to this unresolved atmospheric variability is studied. The hybrid coupled models were tuned to be asymptotically stable and the magnitude, and spatial and temporal structure of the unresolved variability was extracted from observations. The results suggest that this neglected variability can add an important piece of realism and forecast skill to the hybrid models. The models were found to respond linearly to the low-frequency part of the neglected atmospheric variability, in agreement with previous findings with intermediate models. While the wind anomalies associated with the MJO typically explain a small fraction of the unresolved variability, a large fraction of the interannual variability can be excited by this forcing. A large correlation was found between interannual anomalies of Kelvin waves forced by the intraseasonal MJO and the Kelvin waves forced by the low-frequency part of the MJO. That is, in years when the MJO tends to be more active it also produces a larger low-frequency contribution, which can then resonate with the large-scale coupled system. Other kinds of atmospheric variability not related to the MJO can also produce interannual anomalies in the hybrid models. However, when projected on the characteristics of Kelvin waves, no clear correlation between its low-frequency content and its intraseasonal activity was found. This suggests that understanding the mechanisms by which the intraseasonal MJO interacts with the ocean to modulate its low-frequency content may help to better to predict ENSO variability.
Neural Network Model to Predict a Storm Surge
Authors: de Oliveira Marilia M. F. , Ebecken Nelson Francisco F. , de Oliveira Jorge Luiz Fernandes , de Azevedo Santos Isimar 
Published: August 2008

AbstractThe southeastern coast of Brazil is frequently affected by meteorological disturbances such as cold fronts, which are sometimes associated with intense extratropical cyclones. These disturbances cause oscillations on the sea surface, generating low-frequency motions. The relationship of these meteorologically driven forces in low frequency to the storm-surge event is investigated in this work. A method to predict coastal sea level variations related to meteorological events that use a neural network model (NNM) is presented here. Pressure and wind values from NCEP–NCAR reanalysis data and tide gauge time series from the Cananéia reference station in São Paulo State, Brazil, were used to analyze the relationship between these variables and to use them as input to the model. Meteorological influences in the sea level fluctuations can be verified by filtering the astronomical tide frequencies for periods lower than tidal cycles (periods higher than 24 h). Thus, a low-pass filter was applied in the tide gauge and meteorological time series for periods lower than tides to identify more readily the interactions between coastal sea level response and atmospheric-driven forces. Statistical analyses on time and frequency domain were used. Maxima correlations and coherence between the low-frequency sea level and meteorological series could be defined using the time lag of the NNM input variables. The model was tested for 6-, 12-, 18-, and 24-hourly forecasts, and the results were compared with filtered sea level values. The results show that this model is able to capture the effects of atmospheric and oceanic interactions. It can be considered to be an efficient model for predicting the nontidal residuals and can effectively complement the standard constant harmonic analysis model. A case study of a storm that impacted coastal areas of southeastern Brazil in March 1998 was analyzed and indicates that the neural network model can be effectively utilized in the Cananéia region.
Quality of life and inflammation in exacerbations of bronchiectasis
Authors: Courtney JM , Kelly MG , Watt A , Garske L , Bradley J , Ennis M , Elborn JS 
Published: August 2008

Patients with bronchiectasis often have impaired quality of life (QoL), which deteriorates with exacerbations. The aim of this study was to investigate changes in QoL and how these were influenced by changes in airway physiology and inflammation in patients with bronchiectasis before and after resolution of an exacerbation. Sputum induction and a QoL questionnaire were undertaken on the first day, day 14, and 4 weeks after completion of intravenous antibiotics (day 42). Eighteen patients (12 female) were recruited, median (IQ range) age of 54 (47–60) years. There was a trend towards an improvement in lung function from visit 1 to visit 2, but this was not statistically significant. C-reactive protein (CRP) [mean (SEM)] reduced between visit 1 and visit 2 [55.4 (21.5) vs 9.4 (3.1) mg/L, P = 0.03] but did not increase significantly on visit 3 [44.4 (32.9) mg/L, P = 0.27]. The median (interquartile range) sputum cell count (×106 cells/g of sputum) decreased from visit 1 to visit 2 [21.6 (11.8–37.6)–13.3 (6.7–22.9) × 106 cells/g, respectively, P = 0.008] and increased from visit 2 to visit 3 [26.3 (14.1–33.6) × 106 cells/g, P = 0.03]. All soluble markers of inflammation significantly reduced from visit 1 to visit 2 but increased on visit 3 with the exception of TNF-α. Regarding QoL, three of the four domains (dyspnoea, emotional, mastery) significantly improved from visit 1 to visit 2 but did not change between visit 2 and visit 3. The improvements in QoL scores could not be explained by the improvements in lung function or inflammatory markers.
Anabolic steroids in COPD: a review and preliminary results of a randomized trial
Authors: Sharma S , Arneja A , McLean L , Duerksen D , Leslie W , Sciberras D , Lertzman M 
Published: August 2008

Patients with severe chronic obstructive pulmonary disease (COPD) commonly develop weight loss, muscle wasting, and consequently poor survival. Nutritional supplementation and anabolic steroids increase lean body mass, improve muscle strength, and survival in patients enrolled in comprehensive rehabilitation programs. Whether anabolic steroids are effective outside an intensive rehabilitation program is not known. We conducted a prospective, double-blind, placebo-controlled, 16-week trial to study the benefits of anabolic steroids in patients with severe COPD who did not participate in a structured rehabilitation program. Biweekly intramuscular injections of either the drug (nandrolone decanoate) or placebo were administered. Sixteen patients with severe COPD were randomized to either placebo or nandrolone decanoate. The placebo group weighed 55.32 ± 11.33 kg at baseline and 54.15 ± 10.80 kg at 16 weeks; the treatment group weighed 68.80 ± 6.58 at baseline and 67.92 ± 6.73 at 16 weeks. Lean body mass remained unchanged, 71 ± 6 vs. 71 ± 7 kg in placebo group and 67 ± 7 vs. 67 ± 7 in treatment group, at baseline and 16 weeks respectively. The distance walked on 6 min was unchanged at baseline, 8 weeks, and 16 weeks in placebo (291.17 ± 134.83, 282.42 ± 115.39, 286.00 ± 82.63 m) and treatment groups (336.13 ± 127.59, 364.83 ± 146.99, 327.00 ± 173.73 m). No improvement occurred in forced expiratory volume in one second, forced vital capacity, maximal inspiratory pressure, maximal expiratory pressure, VO2 max or 6-min walk distance or health related quality of life. Administration of anabolic steroids (nandrolone decanoate) outside a dedicated rehabilitation program did not lead to either weight gain, improvement in physiological function, or better quality of life in patients with severe COPD.
When FAST is a FAFF: is FAST Scanning Useful in Non-Trauma Patients?
Authors: Maitra Sohom , Jarman Robert D. , Halford Neil W. , Richards Simon P. 
Published: August 2008

Aim/Background: Focused Assessment with Sonography for Trauma (FAST) has evolved into a common point-of-care diagnostic investigation in UK Emergency Departments (ED). Its role in the management of blunt abdominal trauma is well recognised. The aim of this study was to determine if the FAST scan can play a role in the management of non-traumatic patients. Method: A literature review was performed with the emphasis on the use of FAST scanning in the non-trauma setting. Results: In the acutely ill, undifferentiated, septic or decompensated patient, a Focused Assessment for Free Fluid (FAFF) scan may be of benefit, as a goal-directed investigation, to search for free fluid as an indicator of underlying disease source. The presence of free fluid in the non traumatised peritoneum implies primary or secondary intra-abdominal pathology requiring urgent specialist review and management. A FAFF scan can also play a role in the management of patients with abdominal aortic aneurysm, ectopic pregnancy and some thoracic conditions. Conclusion: There is mounting evidence to support the efficacy of using such focused ultrasound, with its 'rule-in' high specificity, for helping reduce the potential differential diagnoses, at an early stage, in critically ill patients. We advocate the use of the term FAFF and not FAST, when emergency ultrasound is applied to non-traumatic clinical cases. We advise its liberal use by accredited clinicians, as part of a structured approach to the assessment of the undifferentiated, unwell patient presenting to emergency departments - especially those in shock or critically ill.
Mast cells and mastocytosis
Authors: Metcalfe Dean D. 
Published: August 2008

AbstractMast cells have been recognized for well over 100 years. With time, human mast cells have been documented to originate from CD34+ cells, and have been implicated in host responses in both innate and acquired immunity. In clinical immunology, they are recognized for their central role in IgE-mediated degranulation and allergic inflammation by virtue of their expression of the high-affinity receptor for IgE and release of potent proinflammatory mediators. In hematology, the clinical disease of mastocytosis is characterized by a pathologic increase of mast cells in tissues, often associated with mutations in KIT, the receptor for stem cell factor. More recently, and with increased understanding of how human mast cells are activated through receptors including the high-affinity receptor for IgE and KIT, specific tyrosine kinase inhibitors have been identified with the potential to interrupt signaling pathways and thus limit the proliferation of mast cells as well as their activation through immunoglobulin receptors.
The phagocytes: neutrophils and monocytes
Authors: Dale David C. , Boxer Laurence , Liles W. Conrad 
Published: August 2008

AbstractThe production and deployment of phagocytes are central functions of the hematopoietic system. In the 1950s, radioisotopic studies demonstrated the high prodution rate and short lifespan of neutrophils and allowed researchers to follow the monocytes as they moved from the marrow through the blood to become tissue macrophages, histiocytes, and dendritic cells. Subsequently, the discovery of the colony-stimulating factors greatly improved understanding the regulation of phagocyte production. The discovery of the microbicidal myeloperoxidase-H2O2-halide system and the importance of NADPH oxidase to the generation of H2O2 also stimulated intense interest in phagocyte disorders. More recent research has focused on membrane receptors and the dynamics of the responses of phagocytes to external factors including immunoglobulins, complement proteins, cytokines, chemokines, integrins, and selectins. Phagocytes express toll-like receptors that aid in the clearance of a wide range of microbial pathogens and their products. Phagocytes are also important sources of pro- and anti-inflammatory cytokines, thus participating in host defenses through a variety of mechanisms. Over the last 50 years, many genetic and molecular disorders of phagocytes have been identified, leading to improved diagnosis and treatment of conditions which predispose patients to the risk of recurrent fevers and infectious diseases.
Transcriptional responses of Arabidopsis thaliana plants to As (V) stress
Authors: Abercrombie Jason M , Halfhill Matthew D , Ranjan Priya , Rao Murali R , Saxton Arnold M , Yuan Joshua S , Stewart C Neal 
Published: August 2008

AbstractBackgroundArsenic is toxic to plants and a common environmental pollutant. There is a strong chemical similarity between arsenate [As (V)] and phosphate (Pi). Whole genome oligonucleotide microarrays were employed to investigate the transcriptional responses ofArabidopsis thalianaplants to As (V) stress.ResultsAntioxidant-related genes (i.e. coding for superoxide dismutases and peroxidases) play prominent roles in response to arsenate. The microarray experiment revealed induction of chloroplast Cu/Zn superoxide dismutase (SOD) (at2g28190), Cu/Zn SOD (at1g08830), as well as an SOD copper chaperone (at1g12520). On the other hand, Fe SODs were strongly repressed in response to As (V) stress. Non-parametric rank product statistics were used to detect differentially expressed genes. Arsenate stress resulted in the repression of numerous genes known to be induced by phosphate starvation. These observations were confirmed with qRT-PCR and SOD activity assays.ConclusionMicroarray data suggest that As (V) induces genes involved in response to oxidative stress and represses transcription of genes induced by phosphate starvation. This study implicates As (V) as a phosphate mimic in the cell by repressing genes normally induced when available phosphate is scarce. Most importantly, these data reveal that arsenate stress affects the expression of several genes with little or unknown biological functions, thereby providing new putative gene targets for future research.
Effect of infant feeding on maternal body composition
Authors: Hatsu Irene E , McDougald Dawn M , Anderson Alex K 
Published: August 2008

AbstractBackgroundWomen gain total body weight and accrue body fat during pregnancy. Breastfeeding has been suggested as an efficient means of promoting postpartum weight loss due to its high energy cost. We investigated the effect of infant feeding mode on maternal body composition.MethodsThis study evaluated maternal weight and percent body fat changes in exclusively breastfeeding versus mixed feeding mothers during the first 12 weeks postpartum using the BOD POD. Twenty four mothers aged 19 – 42 years were studied. Participants were recruited from Athens-Clarke County and surrounding areas of the State of Georgia, USA. The study was conducted between November 2005 and December 2006.ResultsPrepregnancy weight was higher in mixed feeding mothers than in exclusively breastfeeding mothers (68.4 kg vs. 61.4 kg) but the difference was not statistically significant. At 12 weeks postpartum, exclusively breastfeeding mothers had lost more total body weight than mixed feeding mothers (4.41 ± 4.10 kg versus 2.79 ± 3.09 kg; p = 0.072). There was no significant difference in fat weight change between the two groups (4.38 ± 2.06 kg versus 4.17 ± 2.63 kg). However, mixed feeding mothers lost slightly more percent body fat than exclusively breastfeeding mothers (1.90 ± 4.18 kg versus 1.71 ± 3.48 kg), but the difference was not statistically significant. The trend in percent body fat loss was significant among exclusively breastfeeding mothers (p = 0.034) but not mixed feeding mothers (p = 0.081). Exclusively breastfeeding mothers consumed more calories than mixed feeding mothers (1980 ± 618 kcal versus 1541 ± 196 kcal p = 0.08). Physical activity levels were, however, higher in mixed feeding mothers than exclusively breastfeeding mothers.ConclusionOur results provide further evidence that exclusive breastfeeding promotes greater weight loss than mixed feeding among mothers even in the early postpartum period. This suggests that there is the need to encourage mothers to exclusively breastfeed as a means of overweight and obesity prevention.
MicroRNAs can regulate human APP levels
Authors: Patel Neha , Hoang David , Miller Nathan , Ansaloni Sara , Huang Qihong , Rogers Jack T , Lee Jeremy C , Saunders Aleister J 
Published: August 2008

Abstract
A number of studies have shown that increased APP levels, resulting from either a genomic locus duplication or alteration in APP regulatory sequences, can lead to development of early-onset dementias, including Alzheimer's disease (AD). Therefore, understanding how APP levels are regulated could provide valuable insight into the genetic basis of AD and illuminate novel therapeutic avenues for AD. Here we test the hypothesis that APP protein levels can be regulated by miRNAs, evolutionarily conserved small noncoding RNA molecules that play an important role in regulating gene expression. Utilizing human cell lines, we demonstrate that miRNAs hsa-mir-106a and hsa-mir-520c bind to their predicted target sequences in the APP 3'UTR and negatively regulate reporter gene expression. Over-expression of these miRNAs, but not control miRNAs, results in translational repression of APP mRNA and significantly reduces APP protein levels. These results are the first to demonstrate that levels of human APP can be regulated by miRNAs.
Sodium Amytal and Eyelid Conditioning
Authors: Franks C. M. , Laverty S. G. 
Published: August 2008

Sodium amytal has long been regarded as a physiologically inhibiting drug. It is widely used in clinical practice as a sedative and sleep-producing drug, although all of its precise pharmacological effects are not definitely established. It has also been suggested that sodium amytal produces an increase in extra-version, as manifest by an increase in communicativeness, etc. Thus Lindemann (1932) found that after receiving amytal, normal subjects report feeling of increased well-being, co-operativeness, serenity and friendship. Sodium amytal is also used for the reduction of manifest anxiety. Sargant and Slater (1954) cite many examples of its use for this purpose with neurotic subjects; they describe it as useful for “deconditioning to situations likely to produce anxiety”. Masserman (1938) reports that amytal apparently reduces the sympathetic activity in cats which normally results from faradic stimulation from the hypothalamus. It has also been shown to abolish conditioned fear responses in kittens (Bailey and Miller, 1952).The literature related to conditioning is enormous. Hilgard and Marquis (1940) alone have a 973 item reference list at the end of their book. It has been established that anxiety neurotics or anxious subjects condition better than normals (e.g. Welch and Kubis, 1947a, 1947b; Taylor, 1951; Spence and Taylor, 1953; Spence and Farber, 1953). In the terminology of Eysenck (1952, 1953), in which introversion–extraversion and neuroticism are two orthogonal dimensions, anxiety neurotics are part of the groups known as Dysthymics, i.e. they have high scores on both the introversion end of the introversion–extraversion dimension and on the dimension of neuroticism. On the other hand hysterics and psychopaths have been shown to have high scores on the extraversion end of the introversion–extraversion dimension and on the dimension of neuroticism. Figure 1 will make this clear.