bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying Existing Guidelines, Frameworks, Checklists, and Recommendations for Implementing Patient-Reported Outcome Measures: Protocol for a Scoping Review
Authors: Jayasinghe Randi Thisakya , Ahern Susannah , Maharaj Ashika D , Romero Lorena , Ruseckaite Rasa 
Published: March 2024

Background
Implementing patient-reported outcome measures (PROMs) to measure and evaluate health outcomes is increasing worldwide. Along with this emerging trend, it is important to identify which guidelines, frameworks, checklists, and recommendations exist, and if and how they have been used in implementing PROMs, especially in clinical quality registries (CQRs).

Objective
This review aims to identify existing publications, as well as publications that discuss the application of actual guidelines, frameworks, checklists, and recommendations on PROMs’ implementation for various purposes such as clinical trials, clinical practice, and CQRs. In addition, the identified publications will be used to guide the development of a new guideline for PROMs’ implementation in CQRs, which is the aim of the broader project.

Methods
A literature search of the databases MEDLINE, Embase, CINAHL, PsycINFO, and Cochrane Central Register of Controlled Trials will be conducted since the inception of the databases, in addition to using Google Scholar and gray literature to identify literature for the scoping review. Predefined inclusion and exclusion criteria will be used for all phases of screening. Existing publications of guidelines, frameworks, checklists, recommendations, and publications discussing the application of those methodologies for implementing PROMs in clinical trials, clinical practice, and CQRs will be included in the final review. Data relating to bibliographic information, aim, the purpose of PROMs use (clinical trial, practice, or registries), name of guideline, framework, checklist and recommendations, the rationale for development, and their purpose and implications will be extracted. Additionally, for publications of actual methodologies, aspects or domains of PROMs’ implementation will be extracted. A narrative synthesis of included publications will be conducted.

Results
The electronic database searches were completed in March 2024. Title and abstract screening, full-text screening, and data extraction will be completed in May 2024. The review is expected to be completed by the end of August 2024.

Conclusions
The findings of this scoping review will provide evidence on any existing methodologies and tools for PROMs’ implementation in clinical trials, clinical practice, and CQRs. It is anticipated that the publications will help us guide the development of a new guideline for PROMs’ implementation in CQRs.

Trial Registration
PROSPERO CRD42022366085; https://tinyurl.com/bdesk98x

International Registered Report Identifier (IRRID)
DERR1-10.2196/52572
Measuring Physical Functioning Using Wearable Sensors in Parkinson Disease and Chronic Obstructive Pulmonary Disease (the Accuracy of Digital Assessment of Performance Trial Study): Protocol for a Prospective Observational Study
Authors: de Graaf Debbie , de Vries Nienke M , van de Zande Tessa , Schimmel Janneke J P , Shin Sooyoon , Kowahl Nathan , Barman Poulami , Kapur Ritu , Marks Jr William J , van 't Hul Alex , Bloem Bastiaan R 
Published: March 2024

Background
Physical capacity and physical activity are important aspects of physical functioning and quality of life in people with a chronic disease such as Parkinson disease (PD) or chronic obstructive pulmonary disease (COPD). Both physical capacity and physical activity are currently measured in the clinic using standardized questionnaires and tests, such as the 6-minute walk test (6MWT) and the Timed Up and Go test (TUG). However, relying only on in-clinic tests is suboptimal since they offer limited information on how a person functions in daily life and how functioning fluctuates throughout the day. Wearable sensor technology may offer a solution that enables us to better understand true physical functioning in daily life.

Objective
We aim to study whether device-assisted versions of 6MWT and TUG, such that the tests can be performed independently at home using a smartwatch, is a valid and reliable way to measure the performance compared to a supervised, in-clinic test.

Methods
This is a decentralized, prospective, observational study including 100 people with PD and 100 with COPD. The inclusion criteria are broad: age ≥18 years, able to walk independently, and no co-occurrence of PD and COPD. Participants are followed for 15 weeks with 4 in-clinic visits, once every 5 weeks. Outcomes include several walking tests, cognitive tests, and disease-specific questionnaires accompanied by data collection using wearable devices (the Verily Study Watch and Modus StepWatch). Additionally, during the last 10 weeks of this study, participants will follow an aerobic exercise training program aiming to increase physical capacity, creating the opportunity to study the responsiveness of the remote 6MWT.

Results
In total, 89 people with PD and 65 people with COPD were included in this study. Data analysis will start in April 2024.

Conclusions
The results of this study will provide information on the measurement properties of the device-assisted 6MWT and TUG in the clinic and at home. When reliable and valid, this can contribute to a better understanding of a person’s physical capacity in real life, which makes it possible to personalize treatment options.

Trial Registration
ClinicalTrials.gov NCT05756075; https://clinicaltrials.gov/study/NCT05756075

International Registered Report Identifier (IRRID)
DERR1-10.2196/55452
AZITHROMYCIN AND OSELTAMIVIR QUANTIFICATION METHOD DEVELOPED AND VALIDATED USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY IN DRIED BLOOD SPOT
Authors: RAHMANIA TESIA AISYAH , HARAHAP YAHDIANA , SANDY KURNIA 
Published: March 2024

Objective: The development and use of bio-sampling techniques for the analysis of COVID-19 drugs oseltamivir and azithromycin using the Dried Blood Spot technique simultaneously using LC-MS/MS aims to obtain optimal conditions and validated analytical methods using LC-MS/MS according to Food and Drug Administration 2018 recommendations.
Methods: Azithromycin and oseltamivir analyses were performed using LC-MS/MS with C18 Acquity® Bridged Ethylene Hybrid (BEH) column 1.7 m, 100 x 2.1 mm. The matrix sample used is Dried Blood Spot (DBS) with azithromycin and Oseltamivir as the raw material and acyclovir as the internal standard. Optimum analytical conditions were obtained on a gradient mobile phase using 0.1% formic acid-methanol solution with a flow rate of 0.2 ml/minute. The quantification of the analysis was carried out using triple quadrupole mass spectrometry with positive electrospray ionization (ESI) mode.
Results: The calibration curve ranged from 0.5 to 160 g/ml, and the Lower Limit of Quantification (LLOQ) achieved was 25.31 and 25.37 ng/ml. Sensitivity, selectivity, linearity, precision, carry-over, accuracy, stability, and recovery were found to be within the suitable limits and fully validated by the guidelines from the Food and Drug Administration 2018.
Conclusion: The method developed successfully passed all of the FDA's 2018 full validation guidelines, with the LLOQ achieved for azithromycin and Oseltamivir was 25.31 and 25.37 ng/ml.
APPROACH TO OPTIMIZE THE SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM FOR AZILSARTAN MEDOXOMIL USING BOX BEHNKEN DESIGN AND DESIRABILITY FUNCTION
Authors: KUMARI P. V. KAMALA , LIKHITHA G. , HUSSAIN MUSTAQ SHEIK JAKIR 
Published: March 2024

Objective: Develop and optimize a novel self-micro emulsifying drug delivery system (SMEDDS) for enhancing the water solubility of Azilsartan (AZL) by employing the Box-Behnken design and the desirability function.
Methods: The formulation of AZL-SMEDDS consists of clove oil (oil component), Tween 20 (surfactant), propylene glycol (co-surfactant) as the independent variables and the active drug. Using a 3-level Design, the impact of independent variables on the formulation was examined. These variables' specified ranges are 20-40 mg, 50-80 mg, and 5-30 mg for X1, X2 and X3 respectively. Particle size (Y1), PDI (Y2), and dissolution % (Y3) were the response variables investigated in this study.
Results: The results indicated that the optimal values for Clove oil (X1), Tween 20 (X2), and Propylene glycol (X3) were determined to be 28.69, 76.45, and 24.93 (mg), respectively. Based on these optimized conditions, the predicted data points for the response variables Particle Size (Y1), Polydispersity (Y2), and dissolution % (Y3) were determined to be 59.85 nm, 0.729 and 55.406%, respectively.
Conclusion: The empirical results obtained from the optimized formulation exhibited a strong correlation with the predicted values. The optimized AZL-SMEDDS formulation demonstrated a rapid rate of drug solubility and greater bioavailability than AZL powder.
EXPLORATION OF THE ACTIVE COMPOUNDS OF MORINGA OLEIFERA LAM AS HIV-1 REVERSE TRANSCRIPTASE INHIBITOR: A NETWORK PHARMACOLOGY AND MOLECULAR DOCKING APPROACH
Authors: FITRIANA MELANDA , MUN’IM ABDUL , FIRDAYANI  , ADIKUSUMA WIRAWAN 
Published: March 2024

Objective: This study aims to predict the active compound of Moringa oleifera for the treatment of Human Immunodeficiency Virus (HIV), specifically targeting the HIV-1 reverse transcriptase (HIV-1 RT) enzyme using network pharmacology and molecular docking approach.
Methods: The active ingredients of M. oleifera, were screened from the Knapsack database. Subsequently, HIV-1 RT and its related target compounds were retrieved from the Genecard database. The analysis of common targets involved protein-protein interactions (PPI) analysis using string databases and constructing interaction IDs using Cytoscape software. Gene Ontology (GO) functional and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed. Molecular docking studies were conducted using AutoDock Vina software to validate the results of the network pharmacological analysis.
Results: A total of 63 active ingredients and 8601 targets related to HIV-1 RT were identified. The network analysis, encompassing GO and KEGG enrichment, revealed strong associations of common targets with key signaling pathways such as Tumor Necrosis Factor (TNF), Toll Like Receptor (TLR), and apoptosis. Additionally, 11 compounds of M. oleifera including apigenin, benzyl isothiocyanate, benzylamine, caffeic acid, ferulic acid, epicatechin, kaempferol, gallic acid, luteolin, syringic acid and vanillin were identified as potential vital compounds. Molecular docking analysis highlighted apigenin and kaempferol as the most promising compounds, exhibiting the lowest binding affinity to the HIV-1 RT enzyme. These compounds correlated with caspase-3(CASP3), caspase-9 (CASP9), and BCL2 Apoptosis Regulator (BAX) protein, stimulating cell apoptosis through multiple pathways.
Conclusion: The study highlighted that apigenin and kaempferol are potential compound of M. oleifera in HIV-1 treatment through inhibition activity at HIV-1 RT Enzyme.
NORMATIVE JUSTICE AND IMPLEMENTATION OF SHARIA ECONOMIC LAW DISPUTES: QUESTIONING LAW CERTAINTY AND JUSTICE
Authors: Huda Miftakhul , Sumbulah Umi , Nasrulloh  
Published: March 2024

The academic problem stems from the outcomes of decisions issued by Religious Court concerning sharia economic disputes, which fail to meet the criteria of certainty and justice, both at the normative (book in law) and implementation (law in action) levels. The losing parties can only file objections for simple cases and submit an appeal, which contradicts the principle of direct justice (speedy trial). Therefore, This research aims to analyze this issue. The theoretical frameworks employed in this research include the theories of legal certainty and justice, sulh theory, and the theory of judicial power. The findings of the research demonstrate that for the decisions of judges regarding Sharia economic disputes in Religious Courts to meet the requirements of legal certainty and justice, they must adhere to Sharia principles, including: refraining from making things difficult (‘adam al-haraj), reducing burdens (taqlil al-taklif), periodically determining laws, and in line with universal benefit and ensuring equality and justice (al-musawah wa al-ilah). Additionally, the decisions of the panel of judges in examining, deciding and resolving the case are guided by government laws/regulations, Perma, KHES, and Islamic jurisprudence (fiqh) and the judge's ijtihad
Abstrak: Problem akademik bermula dari hasil produk putusan yang dikeluarkan oleh Pengadilan Agama berkaitan dengan sengketa ekonomi syariah, belum memenuhi unsur kepastian dan keadilan, baik dari tataran hukum normatif (book in law) maupun implementatif (law in action). Para pihak yang kalah hanya dapat mengajukan keberatan untuk perkara sederhana dan mengajukan banding. Sehingga hal tersebut bertolak belakang dengan asas contante justitie (speedy trial). Sehingga tujuan penelitian ini adalah untuk menganalisis tentang hal tersebut. Teori yang digunakan dalam penelitian ini antara lain teori kepastian dan keadilan hukum, teori sulh, serta teori kekuasaan kehakiman. Hasil penelitian membuktikan bahwa hasil putusan Hakim berkaitan dengan sengketa ekonomi syariah di Pengadilan Agama agar memenuhi unsur kepastian dan keadilan hukum harus merujuk pada prinsip syariah, meliputi : tidak mempersulit (‘adam al-haraj), mengurangi beban (taqlil al-taklif), penetapan hukum secara periodik, sejalan dengan kemaslahatan universal, dan persamaan dan keadilan (al-musawah wa al-adalah). Selain itu hasil putusan majelis hakim dalam memeriksa, memutus dan menyelesaikan perkara tersebut dilakukan dengan merujuk pada Undang-undang/peraturan pemerintah, Perma, KHES, dan fiqh islam dan ijtihad hakim.
Kata Kunci: Keadilan Normatif Dan Implementatif, Sengketa Hukum Ekonomi Syariah, Kepastian dan Keadilan Hukum
INVESTIGATING THE RESILIENCE OF SALT MARSHES TO EXTERNAL DISTURBANCE
Authors: Pannozzo Natascia , Smedley Rachel K , Carnacina Iacopo , Leonardi Nicoletta 
Published: March 2024

Salt marshes are valuable ecosystems that provide numerous services and
act as natural coastal defences by buffering storm waves and stabilising
sediments. However, it is not clear whether they will be able to retain
their resilience with accelerating rate in sea-level rise, possible
increases in storm intensity and increasing land reclamation. The
current paradigm is that a positive sediment budget supports the
survival and accretion of salt marshes while a negative sediment budget
causes marsh degradation. Here we present the results of a series of
studies that used an integration of modelling and paleoenvironmental
analysis and a sediment budget approach to investigate the resilience of
estuaries and salt marshes to projected rise in sea-level, possible
increases in storm activity and existing anthropogenic disturbance. The
studies were conducted using the Ribble Estuary-NorthWest England-as a
test case, the hydrodynamic model Delft3D to simulate the estuary
morpho-dynamics under selected scenarios, and optically stimulated
luminescence (OSL), geochemistry and particle size distribution analysis
to reconstruct the past evolution and adaptation of the estuary
morphology. Results showed that sea-level rise threatens estuary and
marsh stability by promoting ebb dominance and triggering a net export
of sediment. Conversely, storm surges aid the resilience of the system
by promoting flood dominance and triggering a net import of sediment and
have the potential to counteract the negative impact of sea-level rise
by masking its effects on the sediment budget. The addition of
embankments, on the other hand, can further promote ebb dominance in the
system and intensify sediment export, further threatening marsh
stability.

References

Leonardi, N., Ganju, N.K. and Fagherazzi, S. (2016). A linear
relationship between wave power and erosion determines salt-marsh
resilience to violent storms and hurricanes. Proceedings of the National
Academy of Sciences 113(1), 64-68.
Ganju, N.K., Kirwan, M.L., Dickhudt, P.J., Guntenspergen, G.R., Cahoon,
D.R. and Kroeger, K.D. (2015). Sediment transport-based metrics of
wetland stability. Geophysical Research Letters, 42(19), 7992-8000.
Evaluation of nasal septal deviation and maxillary bone and nasal airway dimensions and volumes using cone-beam computed tomography in patients with unilateral palatal canine displacement: a retrospective study
Authors: Osman Safa A. Azim , Abu Alhaija Elham , AlWahadni Ahed M. , Al Maaitah Emad , Daher Saba , Daher Hasan , AlTal Hamza 
Published: March 2024

ABSTRACT

Objectives
To detect any association between palatally displaced canine (PDC) and nasal septal deviation (NSD), palatal bone thickness and volume, and nasal airway dimensions and volume.

Materials and Methods
A total of 92 patients were included and subdivided into two groups: group 1, unilateral PDCs (44 patients), and group 2, normally erupted canines (NDCs) (48 subjects). The following variables were measured using cone-beam computed tomography: presence and type of NSD, nasal width, inferior conchae, hard palate and nasal septum thickness, maxillary bone and nasal airway volumes.

Results
NSD was detected in 77% and 50% of PDC and NDC subjects, respectively. Within the PDC subjects, significant differences between the displaced and nondisplaced sides were detected. Palate thickness was increased in the canine region and reduced in the molar region. Compared with the control group, PDC subjects had reduced palate thickness and lower nasal airway volume. Two predictors were significant for predicting the odds of PDC occurrence: NSD and maxillary bone volume.

Conclusions
NSD is more frequent in PDC subjects. PDC subjects have reduced palate thickness and decreased nasal airway volume. In the presence of NSD, the odds of developing PDC increase by 3.35 times, and for each one-unit increase in the maxillary bone volume, the odds of developing PDC decrease by 20%.
Ten years of Poland in the European Space Agency: perspectives for increased use of Earth observation satellite data
Authors: Zieliński Hubert , Lewiński Stanisław , Ryzenko Jakub 
Published: March 2024

Abstract
The article presents an assessment of Poland's participation in Earth observation programmes within its 10 years of membership in the European Space Agency (ESA). A diagnosis of the current state of affairs makes it possible to assess the actions taken to date by policy-makers and to indicate the directions which should be taken in the future so that satellite data on the Earth's surface is more widely utilised and available.
Changes in biothermal conditions in the Sudetes Mountains and their foreland in relation to the circulation conditions
Authors: Miszuk Bartłomiej , Furdak Agnieszka 
Published: March 2024

Abstract
Progressing climate change is often reflected in changing biometeorological conditions. The Sudetes Mountains, located in the Polish–Czech border area, are concerned by this phenomenon. The goal of this paper is to evaluate the influence of atmospheric circulation on multiannual changes in biothermal conditions using the UTCI index. In the analysis, data for 1991–2020, from both Polish and Czech meteorological stations, was considered, while the circulation factor was evaluated using the Lityński classification. The research indicated a positive tendency of UTCI values for the majority of circulation types, which consequently contributed to a decrease in the frequency of cold stress categories. In the summits, a decline in the number of days with extreme cold stress was the most characteristic feature, especially under anticyclonic and northern circulation. Tendencies of heat stress occurrence were in most cases statistically insignificant, except for cyclonic and transitional circulation.
RIQUEZA DE EUGLENOPHYTA EN LA LAGUNA YARINACOCHA PUCALLPA, UCAYALI), INCLUYENDO NUEVOS REGISTROS PARA EL PERÚ
Authors: MENDOZA-CARBAJAL Leonardo Humberto , ROJAS-BAEZ Elian , CASAS-OCHOA Jose , PUCAMACAJIA Maria Angela , MORALES Luz , SULCA Angela , GARCÍA Dana , GALLOSO-SANCHEZ Nataly , CÓRDOVA Antuane , ALVAREZ Josselyn 
Published: March 2024

El presente estudio tuvo como objetivo describir la riqueza del Phylum Euglenophyta asociado al período de vaciante en la Laguna Yarinacocha, Pucallpa, Perú, durante el año 2022. La investigación fue llevada a cabo en 8 estaciones de muestreo ubicadas dentro de la laguna. Los métodos de colecta, identificación y análisis de la comunidad biológica en estudio fueron realizados en base a lo establecido por Ortega et al. (2014). Se presentan 22 taxa como nuevos reportes para el país. La comunidad de euglenoides estuvo compuesta principalmente por 1 orden (Euglenales), 2 familias (Euglenaceae y Phacaceae) y 6 géneros (Euglena, Euglenaformis, Strombomonas, Trachelomonas, Lepocinclis y Phacus). La mayor riqueza específica se encontró en la estación cerca al caserío “Nueva luz de Fátima", mientras que la menor fue registrada frente al restaurante “La Jungla Ecolodge” y puerto San Juan. Se brinda información para poder ser utilizada como línea base para futuros estudios sobre el fitoplancton de Yarinacocha y su potencial utilidad como indicador de contaminación.
O Exercício de Como Fazer uma Relação Instigante com a Educação em Saúde
Authors: Canuto Angela Maria Moreira 
Published: March 2024

O livro trata da biografia de Rubem Alves, como autor profícuo que escreveu mais de cem obras. Cursou doutorado, mas foi um crítico das publicações científicas, onde a opinião pessoal não tinha valor, e apenas as de outrem, citando a maneira impessoal com que os verbos eram postos. Foi um sonhador que sempre soube recomeçar, sem temer as vicissitudes da vida. Tornou-se um orador que encantava as plateias. O autor Gonçalo Júnior, jornalista , conseguiu construir um retrato de uma história de vida onde de tudo houve, desde dramas pessoais e relações de casamento desfeitas, até a descoberta de um novo amor, mas também de doenças que, irremediavelmente, comprometeram uma vida que teimava em viver.
Características gerais dos egressos de um programa de residência de enfermagem
Authors: VERÇOSA ROSA CAROLINE MATA , Lima Lucy Vieira da Silva 
Published: March 2024

Objetivo: descrever as características gerais dos egressos de um programa de residência em enfermagem. Método: estudo quantitativo, descritivo, transversal. A pesquisa envolveu egressos de um programa de residência de enfermagem que concluíram o curso entre os anos de 2007 a 2019. Para coleta dos dados foi utilizado um questionário misto com perguntas de múltipla escolha. Os dados foram submetidos a análise descritiva por porcentagem simples. Resultados: 96% dos egressos são do sexo feminino e 4% do sexo masculino. A faixa etária predominante é entre 20-30 anos (56%). A maioria dos egressos (90%) concluiu a graduação em instituições públicas de ensino superior. Quanto ao ano de conclusão da graduação, 18% concluiu em 2012, seguido dos anos de 2013, 2014 e 2015 com 14% cada. Quanto a conclusão da residência, 22% concluiu em 2017, seguido por 2016 (14%). Dos egressos, 88% estão empregados, desses, 78% atuam na área que se especializou. Quanto ao caráter do trabalho, 50% são enfermeiros assistenciais, 20% enfermeiros docentes e 18% enfermeiros assistenciais e docentes. Ao concluir a residência, 36% ingressaram em especializações stricto sensu. Conclusão: a residência em enfermagem é uma modalidade de ensino que proporciona uma extensa formação teórica e prática, além de despertar no egresso o desejo de continuar sua formação. Dessa forma, pensar no processo de formação dos enfermeiros contribui para a melhoria da assistência à saúde da população em geral ao formar profissionais de enfermagem capacitados para atuar nas atividades assistenciais e gerenciais, além das áreas de ensino e pesquisa.