bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Theoretical Edges and Exclusionary Borders: Towards a Genealogy of “Analyzability” in Jungian Psychoanalysis1
Authors: Sierck Alex 
Published: March 2024

AbstractAn oft‐repeated and largely unexamined assumption in Jungian psychoanalysis is the notion of “analyzability”, that is, of an individual's ability or present capacity to think symbolically. It is often taught that if someone is unable to think symbolically, a depth analysis is not possible. Such an individual may be more aptly suited for supportive psychotherapy, the argument goes, an experience that may very well lead to the development of the ego's capacity for symbolic thought but is not, in and of itself, a Jungian analysis. While this sort of categorical thinking has, at times, crossed over into ontological claims about individuals and groups, the notion of analyzability encountered in psychoanalytic theory and praxis is often cloaked in facially neutral language. The impact, however, has been anything but neutral in effect. In this paper, I propose a softening of our theoretical edges through a genealogy of the category of analyzability within the broader history of psychoanalysis. Through this excavation, I explore the contingent nature of the category of analyzability, how it has constricted knowledge, perpetuated inequality, and, more broadly, obscured ways of knowing. In so doing, I recover the radically democratic potential that lies at the heart of Jungian psychoanalysis.
Greening the energy future: Role of energy innovation as policy driver
Authors: Sheng Jin , Sinha Avik , Mansoor Sadia , Zafar Muhammad Wasif 
Published: March 2024

AbstractEnergy innovation is the backbone of a sustainable future. By harnessing the power of innovation, we can accelerate the transition to a greener energy future by improving energy efficiency, integrating renewable energy sources, developing energy storage solutions, and ensuring grid flexibility. As the renewable energy is being characterized as a major driver of sustainability, the innovational endeavors need to be directed in this pursuit. Based on this objective, this study explores the impact of energy innovation and education on renewable energy use by controlling the impact of economic growth, financial development, and oil prices for the OECD countries over the period of 1995–2020. The empirical results obtained from second‐generation panel methods indicate that energy innovation and education increase renewable energy use in these countries. Similarly, economic growth, financial development, and oil prices also sure the use of renewable energy. From these results, our study offers number of contributions to the literature, policy, and practice. More specifically, we argue that energy innovation and education can play an important role to increase the use of energy produce from renewable sources. Moreover, financial development can play a key role in the production of renewable energy in the long‐term projects by providing funding. The empirical results obtained from second‐generation panel methods suggest that energy innovation and education play a crucial role in increasing renewable energy use in these countries. Effective policy support is crucial in fostering innovation, promoting clean energy adoption, and creating opportunities for economic growth. Together, we can work toward a greener and more resilient energy future.
Adherence to a restrictive red blood cell transfusion strategy in critically ill patients: An observational study
Authors: Bjurström Martin F. , Linder Ylva C. , Kjeldsen‐Kragh Jens , Bengtsson Jesper , Kander Thomas 
Published: March 2024

AbstractBackgroundRandomized controlled trials relatively consistently show that restrictive red blood cell (RBC) transfusion strategies are safe and associated with similar outcomes compared to liberal transfusion strategies in critically ill patients. Based on these data, the general threshold for RBC transfusion was changed to 70 g/L at a 9‐bed tertiary level intensive care unit in September 2020. Implementation measures included lectures, webinars and feedback during clinical practice. The aim of this study was to investigate how implementation of a restrictive transfusion strategy influenced RBC usage, haemoglobin trigger levels and adherence to prescribed trigger levels.MethodsIn this registry‐based, observational study, critically ill adult patients without massive bleeding were included and divided into a pre‐cohort, with admissions prior to the change of transfusion strategy, and a post‐cohort, with admissions following the change of transfusion strategy. These cohorts were compared regarding key RBC transfusion‐related variables.ResultsIn total 5626 admissions were included in the analyses (pre‐cohort n = 4373, post‐cohort n = 1253). The median volume (interquartile range, IQR) of RBC transfusions per 100 admission days, in the pre‐cohort was 6120 (4110–8110) mL versus 3010 (2890–4970) mL in the post‐cohort (p < .001). This corresponds to an estimated median saving of 1128 € per 100 admission days after a restrictive RBC transfusion strategy was implemented. In total, 26% of the admissions in the pre‐cohort and 19% in the post‐cohort (p < .001) received RBC transfusion(s) during days 0–10. Both median (IQR) prescribed trigger levels (determined by intensivist) and actual haemoglobin trigger levels (i.e., levels prior to actual administration of transfusion) were higher in the pre‐ versus post‐cohort (90 [80–100] vs. 80 [72–90] g/L, p < .001 and 89 [82–96] g/L vs. 83 [79–94], p < .001, respectively). Percentage of days without compliance with the prescribed transfusion trigger was higher in the pre‐cohort than in the post‐cohort (23% vs. 14%, p < .001). Sensitivity analyses, excluding patients with traumatic brain injury, ischemic heart disease and COVID‐19 demonstrated similar results.ConclusionsImplementation of a restrictive transfusion trigger in a critical care setting resulted in lasting decreased RBC transfusion use and costs, decreased prescribed and actual haemoglobin trigger levels and improved adherence to prescribed haemoglobin trigger levels.
Hypertensive disorders of pregnancy, neonatal outcomes and offspring developmental delay in Japan: The Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study
Authors: Chen Geng , Ishikuro Mami , Ohseto Hisashi , Murakami Keiko , Noda Aoi , Shinoda Genki , Orui Masatsugu , Obara Taku , Kuriyama Shinichi 
Published: March 2024

AbstractIntroductionDevelopmental delay at an early age indicates the probability of continued problems after school age. Hypertensive disorders of pregnancy (HDP) are associated with developmental delays in offspring, with inconsistent outcomes. Neonatal outcomes vary according to HDP exposure and are relevant to development in later years. Here we aimed to clarify the relationship between HDP and developmental delay in offspring and whether neonatal outcomes mediate this association.Material and methodsWe used data from 5934 mother–child pairs from the Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study, a prospective cohort study conducted in Japan between July 2013 and March 2017. The Ages and Stages Questionnaires, third edition, at 24 and 42 months of age, measured developmental delay in five areas. We performed multivariate quasi‐Poisson regression and causal mediation analysis by neonatal outcomes.ResultsAt 24 months of age, compared to offspring born from normotensive mothers, offspring born from HDP‐affected mothers were more likely to experience developmental delay (risk ratio [RR] 1.29, 95% confidence interval [CI]: 1.09–1.52) in the areas of communication (RR 1.21, 95% CI: 1.00–1.45) and personal‐social (RR 1.15, 95% CI: 1.03–1.28). This association was mediated by neonatal outcomes: preterm birth, neonatal asphyxia, NICU admission, and neonatal small head circumference. No association was observed between HDP and developmental delay at 42 months of age.ConclusionsExposure to HDP during fetal life is associated with offspring developmental delay. This association is partly mediated by neonatal outcomes.
Mindset profiles of secondary school students: Associations with academic achievement, motivation and school burnout symptoms
Authors: Altikulaç Sibel , Janssen Tieme W. P. , Yu Junlin , Nieuwenhuis Smiddy , Van Atteveldt Nienke M. 
Published: March 2024

AbstractBackgroundAccording to Dweck's mindset theory, implicit beliefs (a.k.a. mindset) have an organizing function, bringing together mindset, achievement goals and effort beliefs in a broader meaning system. Two commonly described meaning systems are a growth‐mindset meaning system with mastery goals and positive effort beliefs, and a fixed‐mindset meaning system with performance goals and negative effort beliefs.AimsBecause of assumed heterogeneity within these two meaning systems, we aim to (1) examine multiple‐mindset profiles based on mindset, achievement goals and effort beliefs, by using a data‐driven person‐oriented approach, and (2) relate these different profiles to several outcome measures (academic achievement, motivation and school burnout symptoms).SampleSelf‐report questionnaire data were collected from 724 students (11.0–14.7 y.o.; 46.7% girl; 53.3% boy; Mage = 12.8 y.o.).MethodsLatent profile analysis was conducted using mindset, achievement goals and effort beliefs.ResultsFour profiles were revealed: one fixed‐mindset profile and three growth‐mindset profiles, which differed in their performance goal levels (low, moderate and high). Growth‐mindset students with low‐ or moderate‐performance goals had more advantageous outcomes, for example, higher math grades and lower school burnout symptoms, compared to growth‐mindset students with high‐performance goals. Fixed‐mindset students had the least advantageous outcomes, for example, lower grades, less intrinsic motivation and more school burnout symptoms.ConclusionsOur study emphasizes the importance of taking a holistic approach when examining mindset meaning systems, revealing the importance of the level of performance goals and including multiple academic outcomes.
What do platform workers in the UK gig economy want?
Authors: Martindale Nicholas , Wood Alex J. , Burchell Brendan J. 
Published: March 2024

AbstractDespite the considerable debate concerning the gig economy, research has yet to investigate what platform workers themselves want. In part, this is due to the difficulty of undertaking traditional social surveys in this sector. Therefore, this article makes use of a novel research design that generates a strategic non‐probability sample of 510 platform workers with which to investigate workers’ preferences regarding labour rights, representation and voice. Findings suggest strong support for labour rights, trade unions and co‐determination. The low pay, insecurity, risk and lack of organizational voice that we find provides a rationale for these preferences. Moreover, platform workers’ preferences are seemingly influenced by wider inequalities, with significant differences according to gender and country of birth.
Synthesis, in silico screening, and biological evaluation of novel pyridine congeners as anti‐epileptic agents targeting AMPA (α‐amino‐3‐hydroxy‐5‐methylisoxazole) receptors
Authors: Tyagi Shivani , Mishra Rakhi , Mazumder Avijit , Mazumder Rupa , Singh Gurvinder , Pandey Pratibha 
Published: March 2024

AbstractThe research involves the synthesis of a series of new pyridine analogs 5(i‐x) and their evaluation for anti‐epileptic potential using in silico and in vivo models. Synthesis of the compounds was accomplished by using the Vilsmeier‐Haack reaction principle. AutoDock 4.2 was used for their in silico screening against AMPA (‐amino‐3‐hydroxy‐5‐methylisoxazole) receptor (PDB ID:3m3f). For in vivo testing, the maximal electroshock seizure (MES) model was used. The physicochemical, pharmacokinetic, drug‐like, and drug‐score features of all synthesized compounds were assessed using the online Swiss ADME and Protein Plus software. The in silico results showed that all the synthesized compounds 5(i‐x) had 1–3 interactions and affinities ranging from −6.5 to −8.0 kJ/mol with the targeted receptor compared to the binding affinities of the standard drug phenytoin and the original ligand of the target (P99), which were −7.6 and −6.8 kJ/mol, respectively. In vivo study results showed that the compound 5‐Carbamoyl‐2‐formyl‐1‐[2‐(4‐nitrophenyl)‐2‐oxo‐ethyl]‐pyridinium gave 60% protection against epileptic seizures compared to 59% protection afforded by regular phenytoin. All of them met Lipinski's rule of five and had drug‐likeness and drug score values of 0.55 and 0.8, respectively, making them chemically and functionally like phenytoin. According to the findings of the studies, the synthesized derivatives have the potential to be employed as a stepping stone in the development of novel anti‐epileptic drugs.
Implications of drug intoxication on donor utilization and outcomes in liver transplantation
Authors: Adjei Michie , Wisel Steven A. , Yang Ju Dong , Nissen Nicholas N. , Kim Irene K. , Steggerda Justin A. 
Published: March 2024

AbstractIntroductionThis study evaluates the implications of drug intoxication (DI) on donor utilization and outcomes in liver transplantation (LT).MethodsThe UNOS STAR database was evaluated for all potential donors and adult, first‐time, whole LT between 2005 and 2019. Logistic regression analyses evaluated liver utilization; proportional hazards modeling assessed risk of 1‐year graft loss.ResultsA total of 132 783 potential donors (10 205, 7.7% from DI), and 90 612 adult LT were identified (7490, 8.3% from DI). DI donors had median age 32 years (IQR 26–40 years, p < .001), were 42.6% female (n = 4346), and 15.5% were DCD donors (n = 1583). Utilization of DI donors changed over time, such that by 2015–2019 they were the most likely donor cause of death (COD) to be utilized. Among LT recipients, there were insignificant differences (<2% variance) in age, gender, ethnicity, and etiology of liver disease according to donor COD. Recipients with MELD scores >30 more frequently received grafts from donors with trauma (23.8%) and DI (21.8%) versus cardiovascular (20.0%) and CVA/stroke (19.9%, p < .001). Among DBD donors, DI‐COD was associated with superior 1‐year graft survival compared to donors from trauma (HR 1.172, 95% CI 1.057–1.300) and CVA/stroke (HR 1.404, 95% CI 1.264–1.561, p < .001). Donor COD was not significantly associated with 1‐year graft loss among DCD donors.ConclusionsThere is an increased likelihood of donor utilization when COD is drug overdose and an increased likelihood of 1‐year graft survival compared to donors from trauma, CVA/stroke, and other COD.
Navigating the spectrum of double‐outlet right ventricle presentations: Outcomes from a contemporary cohort based on subtypes
Authors: Öcal Aydın , Demirci Oya , Kahramanoğlu Özge , Ayhan Işıl , Erol Nurdan , Yücel İlker Kemal 
Published: March 2024

AbstractPurposeOur aim in this study was to investigate the prenatal and postnatal prognosis of double outlet right ventricle (DORV) cases diagnosed prenatally by analyzing the outcomes based on the subtype.MethodsThis study is a retrospective chart review. Cases diagnosed with fetal DORV by prenatal ultrasound in the maternal–fetal medicine department of our hospital between 2014 and 2022 were included. Data on maternal characteristics, fetal echocardiographic features (type of DORV), pregnancy and neonatal outcomes (termination of pregnancy [TOP], intrauterine fetal death [IUD], neonatal death [NND], death in infancy (IND), survival) were collected and analyzed.ResultsNinety‐nine cases of prenatally diagnosed cases of DORV were included. The prenatal diagnosis was right in 97% of the liveborn fetuses. The cases were classified into subtypes, including transposition of great arteries (TGA), Fallot, ventricular septal defect (VSD), remote, and heterotaxy types. The cohort consisted of 32.3% TGA type, 19.1% fallot type, 11.1% VSD type, 2% remote type, and 35.3% heterotaxy type of DORV. An additional cardiac anomaly was observed in 87% and an extra‐cardiac anomaly was observed in 54% of the cases. When we excluded the cases with heterotaxy type but without any chromosomal abnormality, additional genetic abnormalities were detected in 42% of the remaining cases. Outcome of pregnancy was livebirth in 68/99 (68.7%), IUFD in 5/99 (5.1%), and TOP in 26/99 (26.3%). Postnatal cardiac surgical repair was performed in 48 cases. Survival among livebirths was 39/68 (57.3%). Twenty‐nine neonates or infants who had additional cardiac anomalies and/or genetic abnormalities died before any surgical intervention. The postoperative survival rate was 39/48 (81.2%).ConclusionThe prognosis in DORV depends on the anatomical subtype, the presence, and severity of associated anomalies. Survival increases in isolated cases without any additional structural or genetic anomalies.
Transient postictal dysphagia in older adults with focal structural epilepsy
Authors: Lapa Sriramya , Schwingshackl Anna , Frank Ulrike , Rosenow Felix , Mann Catrin , Strzelczyk Adam 
Published: March 2024

AbstractObjectiveSeizures can cause transient neurological symptoms, such as hemiparesis and aphasia. However, temporary swallowing changes leading to postictal dysphagia have not been previously described. Therefore, this study evaluated the presence of swallowing disorders following seizure. In addition, dysphagia severity and duration of any recovery from dysphagic symptoms were investigated.MethodsThe local clinical database of all fiberoptic endoscopic evaluation of swallowing (FEES) examinations performed from 2008 to 2019 was screened for patients diagnosed with seizures, but excluding patients with intensive care unit admission or intubation >24 h. Patient charts were evaluated to identify preexisting dysphagia or potential concurrent medical causes for dysphagia, including hyponatremia, increased intracranial pressure, sepsis, or other encephalopathies associated with infections, or other possible causes at the time of admission. Patients receiving >.5 defined daily doses of benzodiazepines or neuroleptics were also excluded. Age, sex, seizure semiology and etiology, comorbidities, concurrent pneumonia, and dysphagia course during hospitalization were evaluated as predictors of the occurrence of dysphagia or its potential duration.ResultsWe identified 41 patients with dysphagia following a seizure, without evidence of any concurrent cause of swallowing dysfunction. These patients all presented with focal structural epilepsy, they had a mean age of 79 ± 11.3 years (range = 44–95 years), and 21 were women. The mean Elixhauser Comorbidity Score was 4.8. Hospital‐acquired pneumonia was detected in 21 patients (51.2%). FEES diagnosed mild and severe dysphagia in 21 (51.2%) and 20 (48.8%) patients, respectively. Dysphagia improved significantly (p = .001) during hospitalization, persisting for an average of 3.9 days (median = 3 days, SD = 2.07 days, range = 1–8 days).SignificanceDysphagia is a potential transient neurological deficit following seizure. Our findings suggest that older patients, with focal structural epilepsy, are at risk for postictal dysphagia. Further studies are needed to ascertain the prevalence, complications, and predictors of postictal dysphagia. Dysphagia screening may improve early detection in patients with relevant risk factors, as well as reduce the occurrence of aspiration pneumonia.
RETRACTED: Effects of predictive nursing interventions on pressure ulcer in elderly bedridden patients
Authors: Deng Gui‐Liu , Lei Yu‐Ling , Tan Hui , Geng Bing‐Chao , Liu Zhen 
Published: March 2024

AbstractThe study explores the impact of predictive nursing interventions on pressure ulcers (PUs) in elderly bedridden patients. A total of 120 elderly bedridden patients from the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture between August 2019 and August 2023 were selected as the subjects of the study and were randomly divided into an observation group and a control group using a random number table method. The control group received conventional nursing care, while the observation group received predictive nursing interventions. The study compared the incidence of PUs, Braden scale scores, the onset time of PUs, self‐rating anxiety scale (SAS) scores, self‐rating depression scale (SDS) scores, and nursing satisfaction between the two groups. In elderly bedridden patients, the application of predictive nursing interventions significantly reduced the incidence of PUs (p < 0.001), significantly lowered the SAS and SDS scores (p < 0.001), and also significantly increased Braden scale scores (p < 0.001) and delayed the onset time of PUs (p < 0.001). Additionally, it improved patients' nursing satisfaction (p = 0.008). Predictive nursing interventions in elderly bedridden patients have good application effects, reducing the occurrence of PUs, delaying the time of onset in patients, improving patients' negative emotions and enhancing nursing satisfaction rates. It is worthy of widespread use.
SGLT2i improves kidney senescence by down‐regulating the expression of LTBP2 in SAMP8 mice
Authors: Zeng Lu , Li Jie , Gao Fanfan , Song Yangyang , Wei Limin , Qu Ning , Chen Shengnan , Zhao Xue , Lei Zitong , Cao Wenya , Chen Lei , Jiang Hongli 
Published: March 2024

AbstractSenescent kidney can lead to the maladaptive repairment and predispose age‐related kidney diseases. Here, we explore the renal anti‐senescence effect of a known kind of drug, sodium‐dependent glucose transporters 2 inhibitor (SGLT2i). After 4 months intragastrically administration with dapagliflozin on senescence‐accelerated mouse prone 8 (SAMP8) strain mice, the physiologically effects (lowering urine protein, enhancing glomerular blood perfusion, inhibiting expression of senescence‐related biomarkers) and structural changes (improving kidney atrophy, alleviating fibrosis, decreasing glomerular mesangial proliferation) indicate the potential value of delaying kidney senescence of SGLT2i. Senescent human proximal tubular epithelial (HK‐2) cells induced by H2O2 also exhibit lower senescent markers after dapagliflozin treatment. Further mechanism exploration suggests LTBP2 have the great possibility to be the target for SGLT2i to exert its renal anti‐senescence role. Dapagliflozin down‐regulate the LTBP2 expression in kidney tissues and HK‐2 cells with senescent phenotypes. Immunofluorescence staining show SGLT2 and LTBP2 exist colocalization, and protein‐docking analysis implies there is salt‐bridge formation between them; these all indicate the possibility of weak‐interaction between the two proteins. Apart from reducing LTBP2 expression in intracellular area induced by H2O2, dapagliflozin also decrease the concentration of LTBP2 in cell culture medium. Together, these results reveal dapagliflozin can delay natural kidney senescence in non‐diabetes environment; the mechanism may be through regulating the role of LTBP2.
First evidence of prickly shark, Echinorhinus cookei Pietschmann 1928, aggregation on seamounts in the eastern Pacific, Panama
Authors: Guzman Hector M. , Real Candy K. , Kaiser Stefanie 
Published: March 2024

AbstractIn May 2022, twelve prickly sharks, Echinorhinus cookei Pietschmann 1928, were sighted at 151–350 m depth in the Cordillera de Coiba seamounts, Pacific Panama. This discovery expands our knowledge of the distribution and habitat use of this rare deep‐sea species. It underscores the potential significance of the Cordillera de Coiba seamounts, an offshore marine protected area, as a critical habitat for E. cookei, a species threatened by commercial fishing. Although unverified reports exist on its presence in the tropical eastern Pacific, this publication represents the first documented record of live specimens of E. cookei in Panama.