bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Analysis of Bursting Pressure Prediction Methods for Steam Generator Tube With Volume Defect
Authors: Han Yile , Huang Song , Hui Hu 
Published: February 2024

Abstract
This paper compares the difference and accuracy of bursting pressure prediction based on the flow stress σf prediction method, plastic collapse prediction method, and ductile damage model prediction method in Inconel 690 steam generator tube (SGT) with volume defect. The tensile and smooth tube bursting tests determine the parameters required for the three prediction methods. The three methods predict the bursting pressures for four deep volume defects in SGT. The results are compared and analyzed with the experimental data. The results show that the ductile damage model prediction method is the best to predict the SGT bursting pressure error with volume defects simulating the structure's deformation and damage failure process.
Search for the f(R, T) gravity functional form via gaussian processes
Authors: Fortunato J. A. S. , Moraes P. H. R. S. , de Lima Júnior J. G. , Brito E. 
Published: February 2024

AbstractThe f(R, T) gravity models, for which R is the Ricci scalar and T is the trace of the energy–momentum tensor, elevate the degrees of freedom of the renowned f(R) theories, by making the Einstein field equations of the theory to also depend on T. While such a dependence can be motivated by quantum effects, the existence of imperfect or extra fluids, or even a cosmological “constant” which effectively depends on T, the formalism can truly surpass some deficiencies of f(R) gravity. As the f(R, T) function is arbitrary, several parametric models have been proposed ad hoc in the literature and posteriorly confronted with observational data. In the present article, we use gaussian process to construct an $$f(R,T)=R+f(T)$$

f
(
R
,
T
)
=
R
+
f
(
T
)

model. To apply the gaussian process we use a series of measurements of the Hubble parameter. We then analytically obtain the functional form of the function. By construction, this form, which is novel in the literature, is well-adjusted to cosmological data. In addition, by extrapolating our reconstruction to redshift $$z=0$$

z
=
0

, we were able to constrain the Hubble constant value to $$H_0=69.97\pm 4.13\ \hbox {km}\ \hbox {s}^{-1} \ \hbox {Mpc}^{-1}$$

H
0

=
69.97
±
4.13

km

s

-
1

Mpc

-
1

with $$5\%$$

5
%

precision. Lastly, we encourage the application of the functional form herewith obtained to other current problems of observational cosmology and astrophysics, such as the rotation curves of galaxies.
A Fully Test-time Training Framework for Semi-supervised Node Classification on Out-of-Distribution Graphs
Authors: Zhang Jiaxin , Wang Yiqi , Yang Xihong , Zhu En 
Published: February 2024

Graph neural networks (GNNs) have shown great potential in representation learning for various graph tasks. However, the distribution shift between the training and test sets poses a challenge to the efficiency of GNNs. To address this challenge,
HomoTTT
proposes a fully test-time training framework for GNNs to enhance the model’s generalization capabilities for node classification tasks. Specifically, our proposed
HomoTTT
designs a homophily-based and parameter-free graph contrastive learning task with adaptive augmentation to guide the model’s adaptation during the test-time training, allowing the model to adapt for specific target data. In the inference stage,
HomoTTT
proposes to integrate the original GNN model and the adapted model after TTT using a homophily-based model selection method, which prevents potential performance degradation caused by unconstrained model adaptation. Extensive experimental results on six benchmark datasets demonstrate the effectiveness of our proposed framework. Additionally, the exploratory study further validates the rationality of the homophily-based graph contrastive learning task with adaptive augmentation and the homophily-based model selection designed in
HomoTTT
.
First-in-Human Study of the Ataxia Telangiectasia and Rad3-Related (ATR) Inhibitor Tuvusertib (M1774) as Monotherapy in Patients with Solid Tumors
Authors: Yap Timothy A. , Tolcher Anthony W. , Plummer Ruth , Mukker Jatinder Kaur , Enderlin Marta , Hicking Christine , Grombacher Thomas , Locatelli Giuseppe , Szucs Zoltan , Gounaris Ioannis , de Bono Johann S. 
Published: February 2024

Abstract

Purpose:
Tuvusertib (M1774) is a potent, selective, orally administered ataxia telangiectasia and Rad3-related (ATR) protein kinase inhibitor. This first-in-human study (NCT04170153) evaluated safety, tolerability, maximum tolerated dose (MTD), recommended dose for expansion (RDE), pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of tuvusertib monotherapy.

Patients and Methods:
Ascending tuvusertib doses were evaluated in 55 patients with metastatic or locally advanced unresectable solid tumors. A safety monitoring committee determined dose escalation based on PK, PD, and safety data guided by a Bayesian 2-parameter logistic regression model. Molecular responses (MR) were assessed in circulating tumor DNA samples.

Results:
Most common grade ≥3 treatment-emergent adverse events were anemia (36%), neutropenia, and lymphopenia (both 7%). Eleven patients experienced dose-limiting toxicities, most commonly grade 2 (n = 2) or 3 (n = 8) anemia. No persistent effects on blood immune cell populations were observed. The RDE was 180 mg tuvusertib QD (once daily), 2 weeks on/1 week off treatment, which was better tolerated than the MTD (180 mg QD continuously). Tuvusertib median time to peak plasma concentration ranged from 0.5 to 3.5 hours and mean elimination half-life from 1.2 to 5.6 hours. Exposure-related PD analysis suggested maximum target engagement at ≥130 mg tuvusertib QD. Tuvusertib induced frequent MRs in the predicted efficacious dose range; MRs were enriched in patients with radiological disease stabilization, and complete MRs were detected for mutations in ARID1A, ATRX, and DAXX. One patient with platinum- and PARP inhibitor–resistant BRCA wild-type ovarian cancer achieved an unconfirmed RECIST v1.1 partial response.

Conclusions:
Tuvusertib demonstrated manageable safety and exposure-related target engagement. Further clinical evaluation of tuvusertib is ongoing.
Systematic Human Learning and Generalization From a Brief Tutorial With Explanatory Feedback
Authors: Nam Andrew J. , McClelland James L. 
Published: February 2024

Abstract
We investigate human adults’ ability to learn an abstract reasoning task quickly and to generalize outside of the range of training examples. Using a task based on a solution strategy in Sudoku, we provide Sudoku-naive participants with a brief instructional tutorial with explanatory feedback using a narrow range of training examples. We find that most participants who master the task do so within 10 practice trials and generalize well to puzzles outside of the training range. We also find that most of those who master the task can describe a valid solution strategy, and such participants perform better on transfer puzzles than those whose strategy descriptions are vague or incomplete. Interestingly, fewer than half of our human participants were successful in acquiring a valid solution strategy, and this ability was associated with completion of high school algebra and geometry. We consider the implications of these findings for understanding human systematic reasoning, as well as the challenges these findings pose for building computational models that capture all aspects of our findings, and we point toward a role for learning from instructions and explanations to support rapid learning and generalization.
“No Avenging Gibbet”: The 1860 Pemberton Mill Collapse
Authors: Forrant Robert 
Published: February 2024

Abstract
This article examines a New England industrial disaster, the January 10, 1860, collapse in Lawrence, Massachusetts, of the Pemberton Mill. In under five minutes the building caved in and 98, mostly immigrant workers, lost their lives. An inquest assigned blame to one individual. The question remains: Was justice done?
Investigating Possible Urban-Induced Precipitation Variations around Louisville, Kentucky
Authors: Kingsberry Isaiah , Naylor Jason 
Published: February 2024

Abstract
This study examines ground-based precipitation observations recorded by a high-density gauge network located within approximately 40 km of the urban center of Louisville, Kentucky. An analysis of April–October events reveals that precipitation is significantly greater on the downwind side of Louisville than on the upwind side, particularly when precipitation systems have a westerly component to their motion. The mean difference between downwind and upwind precipitation across all events is 20%. This value is smaller for widespread precipitation events (i.e., most or all gauges detect precipitation) and is larger for isolated events (i.e., rain detected by one-half of the gauges or fewer). The largest and most significant differences between upwind and downwind precipitation amounts occur in association with moist moderate, moist tropical, and transitional air masses.
Theranostics: a multifaceted approach utilizing nano-biomaterials
Authors: Yasir Mohammad , Mishra Ratnakar , Tripathi Alok Shiomurti , Maurya Rahul K. , shahi Ashutosh , Zaki Magdi E. A. , Al Hussain Sami A. , Masand Vijay H. 
Published: February 2024

AbstractBiomaterials play a vital role in targeting therapeutics. Over the years, several biomaterials have gained wide attention in the treatment and diagnosis of diseases. Scientists are trying to make more personalized treatments for different diseases, as well as discovering novel single agents that can be used for prognosis, medication administration, and keeping track of how a treatment works. Theranostics based on nano-biomaterials have higher sensitivity and specificity for disease management than conventional techniques. This review provides a concise overview of various biomaterials, including carbon-based materials like fullerenes, graphene, carbon nanotubes (CNTs), and carbon nanofibers, and their involvement in theranostics of different diseases. In addition, the involvement of imaging techniques for theranostics applications was overviewed. Theranostics is an emerging strategy that has great potential for enhancing the accuracy and efficacy of medicinal interventions. Despite the presence of obstacles such as disease heterogeneity, toxicity, reproducibility, uniformity, upscaling production, and regulatory hurdles, the field of medical research and development has great promise due to its ability to provide patients with personalised care, facilitate early identification, and enable focused treatment.
Mechanisms of the TGF-β1/Smad3-signaling pathway in gender differences in alcoholic liver fibrosis
Authors: Hong Xiaomin , Li Sanqiang , Luo Renli , Yang Mengli , Wu Junfei , Chen Shuning , Zhu Siyu 
Published: February 2024

AbstractThe TGF-β1/Smad3-signaling pathway and gender differences were investigated in alcoholic liver fibrosis. Mice were divided into female normal, female model, male normal, and male model groups. Liver injury and fibrosis were assessed using histopathology and serology. Western blotting was performed to analyze the expression of relevant factors. HSC-T6 cells were divided into estradiol + saline, estradiol + ethanol, testosterone + saline, and testosterone + ethanol groups, and similar assessments were conducted in vitro. Compared with the female model group, the male model group exhibited significantly increased GPT, GOT, TNF-α, IL-6, and testosterone levels, fibrosis rate, and TGF-β1, Smad3, and PCNA expression, and significantly decreased estradiol levels and Caspase-3 expression. The apoptosis rate was higher in the estradiol + ethanol group than in the testosterone + ethanol group, although the testosterone + ethanol group exhibited significantly increased TNF-α, IL-6, Collagen-I, α-SMA, TGF-β1, Smad3, and PCNA expression, and significantly decreased Caspase-3 expression. Alcoholic liver fibrosis showed significant gender differences associated with the TGF-β1/Smad3-signaling pathway.
Social associations and cardiovascular mortality in the United States counties, 2016 to 2020
Authors: Kumar Ashish , Iqbal Kinza , Shariff Mariam , Majmundar Monil , Kalra Ankur 
Published: February 2024

Abstract
Background
The positive aspects of social interaction on health have been described often, with considerably less attention to their negative aspect. This study aimed to assess the impact of social associations on cardiovascular mortality in the United States.

Methods
The Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) data sets from 2016 to 2020 were used to identify death records due to cardiovascular disease in the United States population aged 15 years and older. The social association rate defined as membership associations per 10,000 population, accessed from the 2020 County Health Rankings data was used as a surrogate for social participation. All United States counties were grouped into quartiles based on their social association rate; Q1 being the lowest quartile of social association, and Q4 the highest quartile. Age-adjusted mortality rate (AAMR) was calculated for each quartile. County health factor rankings for the state of Texas were used to adjust the AAMR for baseline comorbidities of county population, using Gaussian distribution linear regression.

Results
Overall, the AAMR was highest in the 4th social association rate quartile (306.73 [95% CI, 305.72-307.74]) and lowest in the 1st social association rate quartile (266.80 [95% CI, 266.41–267.20]). The mortality rates increased in a linear pattern from lowest to highest social association rate quartiles. After adjustment for the county health factor ranks of Texas, higher social association rate remained associated with a significantly higher AAMR (coefficient 15.84 [95% CI, 12.78–18.89]).

Conclusions
Our study reported higher cardiovascular AAMR with higher social associations in the United States, with similar results after adjustment for County Health Rankings in the state of Texas.
Association between freedom of movement and health of nursing home residents with dementia: an exploratory longitudinal study
Authors: van Liempd Suzan , Bolt Sascha , Verbiest Marjolein , Luijkx Katrien 
Published: February 2024

Abstract
Background
Locked doors remain a common feature of dementia units in nursing homes (NHs) worldwide, despite the growing body of knowledge on the negative effects of restricted freedom on residents. To date, no previous studies have explored the health effects of opening locked NH units, which would allow residents to move freely within the building and enclosed garden. This study examines the association between increased freedom of movement and the health of NH residents with dementia.

Methods
This longitudinal, pre-post study involved a natural experiment in which NH residents with dementia (N = 46) moved from a closed to a semi-open location. Data on dimensions of positive health were collected at baseline (T0; one month before the relocation), at one (T1), four (T2) and nine (T3) months after the relocation. Linear mixed models were used to examine changes in positive health over time.

Results
Cognition, quality of life and agitation scores improved significantly at T1 and T2 compared to the baseline, while mobility scores decreased. At T3, improvements in agitation and quality of life remained significant compared to the baseline. Activities of daily living (ADL) and depression scores were stable over time.

Conclusions
Increasing freedom of movement for NH residents with dementia is associated with improved health outcomes, both immediately and over time. These findings add to the growing evidence supporting the benefits of freedom of movement for the overall health of NH residents with dementia.
Comprehensive machine learning-based preoperative blood features predict the prognosis for ovarian cancer
Authors: Wu Meixuan , Gu Sijia , Yang Jiani , Zhao Yaqian , Sheng Jindan , Cheng Shanshan , Xu Shilin , Wu Yongsong , Ma Mingjun , Luo Xiaomei , Zhang Hao , Wang Yu , Zhao Aimin 
Published: February 2024

Abstract
Purpose
Significant advancements in improving ovarian cancer (OC) outcomes have been limited over the past decade. To predict prognosis and improve outcomes of OC, we plan to develop and validate a robust prognosis signature based on blood features.

Methods
We screened age and 33 blood features from 331 OC patients. Using ten machine learning algorithms, 88 combinations were generated, from which one was selected to construct a blood risk score (BRS) according to the highest C-index in the test dataset.

Results
Stepcox (both) and Enet (alpha = 0.7) performed the best in the test dataset with a C-index of 0.711. Meanwhile, the low RBS group possessed observably prolonged survival in this model. Compared to traditional prognostic-related features such as age, stage, grade, and CA125, our combined model had the highest AUC values at 3, 5, and 7 years. According to the results of the model, BRS can provide accurate predictions of OC prognosis. BRS was also capable of identifying various prognostic stratifications in different stages and grades. Importantly, developing the nomogram may improve performance by combining BRS and stage.

Conclusion
This study provides a valuable combined machine-learning model that can be used for predicting the individualized prognosis of OC patients.
Protect the recurrent laryngeal nerves in US-guided microwave ablation of thyroid nodules at Zuckerkandl tubercle: a pilot study
Authors: Hu Ziyue , Wang Lu , Lu Man , Yang Wei , Wu Xiaobo , Xu Jinshun , Zhuang Min , Wang Shishi 
Published: February 2024

Abstract
Background
To evaluate the safety and efficacy of US-guided microwave ablation in patients with thyroid nodules at Zuckerkandl tubercle.

Methods
103 consecutive patients with thyroid nodules at Zuckerkandl tubercle (ZTTN) were enrolled in this study from November 2017 to August 2021. Prior to the surgery or US-guided microwave ablation (MWA), preoperative ultrasound visualization of the recurrent laryngeal nerve (RLN) and ZTTN was performed, the size and the position relationship between them were observed. Patients were followed up at 1, 3, 6, and 12 months after MWA and the volume reduction rates (VRR) of the thyroid nodules were analyzed.

Results
All patients successfully had the RLN and ZTTN detected using ultrasound before surgery or ablation with a detection rate of 100%. For the 103 patients, the majority of ZTTN grades were categorized as grade 2, with the distance from the farthest outside of ZTTN to the outer edge of thyroid ranging between 6.0 and 10.0 mm. The position relationship between ZTTN and RLN was predominantly type A in 98 cases, with type D observed in 5 cases. After MWA, the median nodule volume had significantly decreased from 4.61 (2.34, 8.70) ml to 0.42 (0.15, 1.41) ml and the VRR achieved 84.36 ± 13.87% at 12 months. No nodules regrew throughout the 12-month follow-up period. Of the 11 patients experienced hoarseness due to RLN entrapment before ablation, 7 recovered immediately after separation of the RLN and ZTTN during MWA, 2 recovered after one week, and the other 2 recovered after two months.

Conclusions
The RLN is closely related to ZTTN and mainly located at the back of ZTTN. The RLN can be separated from ZTTN by hydrodissection during MWA. US-guided MWA is a safe and effective treatment for ZTTN.
Differences in anterior chamber depth in keratoconus patients with binocular very asymmetry ectasia
Authors: Wang Zizhen , Ma Haowen , Zhang Yu , Yuan Yifei , Liu Yan , Chen Yueguo 
Published: February 2024

Abstract
Background
To evaluate the difference in anterior chamber depth (ACD) between two eyes among keratoconus patients with binocular very asymmetric ectasia (VAE) and to explore the influencing factors.

Methods
The corneal curvature and ACD in both eyes of patients with VAE were measured by Sirius (version 3.2, CSO, Italy) at the following points: corneal vertex, maximum curvature (apex), and the 1.5 mm, 2.5 mm, and 3.5 mm superior-, inferior-, nasal-, temporal-paracentral from center. The mean pupil power (MPP) and corneal morphology parameters were also measured. Correlations between ACD and curvature and morphology parameters were analyzed by linear regression.

Results
172 eyes of 86 patients (9 to 45 years) were classified into the VAE-N (n = 86) group and the VAE-E group (n = 86) based on the corneal morphology. The central (3.32 ± 0.27 mm versus 3.43 ± 0.29 mm, P < 0.001) and paracentral ACDs increased significantly in the VAE-E group, and the corneal morphology parameters were also significantly higher. The central ACD was significantly correlated with the MPP (r = 0.465), KVf/b (Keratoconus Vertex front/back) (r = 0.306, r = 0.327), and BCVf/b (Baiocchi Calossi Versaci front/back) (r = 0.356, r = 0.416). Linear regression showed good relationships between △ACD and △MPP (R2 = 0.429) and △KVf/b (R2 = 0.504, R2 = 0.536).

Conclusions
The ACD was larger in the VAE-E group. The difference in ACD between the VAE-E and VAE-N groups was significantly correlated with corneal curvature and the extent of corneal elevation, indicating the influences of both the corneal magnification effect and corneal ectasia on ACD.
Increasing trend in hypertension prevalence among Korean adolescents from 2007 to 2020
Authors: Park Peong Gang , Park Eujin , Kang Hee Gyung 
Published: February 2024

Abstract
Background
The purpose of this study was to examine the prevalence of hypertension in Korean adolescents, its long-term trends, and factors associated with the development of hypertension.

Methods
Data of the Korea National Health and Nutrition Examination Survey (KNHANES) from 2007 to 2020 were combined into three time periods (2007–2011, 2012–2016, and 2017–2020). A total of 11,146 Korean adolescents aged 10–18 were included in the analysis. The definition of hypertension was based on the 2017 American Academy of Pediatrics guidelines for hypertension.

Results
The age-adjusted prevalence of hypertension was 5.47%, 7.85%, and 9.92% in 2007–2011, 2012–2016, and 2017–2020, respectively. Long-term trend analysis using Joinpoint analysis over the observation period showed a significantly increasing trend in hypertension prevalence with a mean annual percentage change of 6.4%. Boys, those aged 13–15, those aged 16–18, overweight/obese, and those living in urban areas were more likely to develop hypertension (OR 1.980, 1.492, 3.180, 2.943, and 1.330, respectively).

Conclusion
The prevalence of hypertension in Korean adolescents was higher than the global prevalence of hypertension and showed an increase over a 13–year period. Targeted strategies for prevention and early detection of hypertension are needed in this population.