bluuebunny/crossref_metadata_2025_split huggingface dataset:
A cognitive analytic approach for working alongside young people
Authors: Barnes Nick 
Published: March 2024

Abstract
With heightened demand for evidence-based therapeutic support for children and young people, cognitive analytic therapy (CAT) is well placed to offer ways of working, both directly and indirectly, that have significant impact on young people’s distress and difficulties. As a therapeutic model that is both integrative and transdiagnostic, CAT is fundamentally a relational approach, that allows us to think developmentally as well contextually within and around the therapeutic space. When working alongside young people, CAT embraces a culture of collaboration and co-production that many young people find respectful and accessible, where creativity is embraced and encouraged, seeking to work where the young person is at, working within their zone of proximal development (ZPD) rather than where services expect them to be at. Likewise, CAT acknowledges the complexity of young people’s lives and circumstances and does not seek to offer simplistic or reductionistic answers but engages with some of the uncertainties that they face, allowing for a more fluid, less-binary experience to be validated. CAT allows us to work alongside young people, families and/or networks, where we can offer relationally informed support and understanding, which can be impactful at an individual level through to wider service development. This chapter articulates how CAT offers a meaningful approach for young people by placing relational skills at its core. Recognizing the developing self within the context of a social and relational world opens a myriad of opportunities for where and how we might can be in dialogue with young people.
Getting the balance right
Authors: Coleby Julia , Haycock Sarah , Finnigan Jill , Roberts Hannah , Wyatt Caroline 
Published: March 2024

Abstract
Within a society that offers powerful and often stigmatizing messages about food and bodies, eating distress is frequently either normalized or medicalized, leading to the lived relational experience being lost. We would like to take the opportunity to redress this balance by offering a co-produced account of our experiences of using cognitive analytic therapy (CAT). We begin by making the case for a relational psychological understanding of eating distress, before outlining previous and current applications of CAT practice in this area. We will then consider a relational perspective of seeking help for eating distress through the lens of CAT. Following this, we shall take the reader through the key aspects of CAT with people who struggle with eating distress, including identifying target problems, and considering motivation to change. We explore the value, lived experience, and dilemmas that have arisen when reformulating using sequential diagrammatic reformulations (CAT maps) and reformulation letters. As we move forward to our discussion of the recognition and revision of problematic patterns, we consider how the core relationship-based CAT interventions are essential in scaffolding people to experiment with exits that may be more specific to addressing eating problems. Fittingly, we shall conclude our journey by thinking about the ending of the work and therapeutic relationship.
Natural soda lakes provide compatible conditions for RNA and membrane function that could have enabled the origin of life
Authors: Cohen Zachary R , Ding Dian , Zhou Lijun , DasGupta Saurja , Haas Sebastian , Sinclair Kimberly P , Todd Zoe R , Black Roy A , Szostak Jack W , Catling David C 
Published: March 2024

Abstract
The origin of life likely occurred within environments that concentrated cellular precursors and enabled their co-assembly into cells. Soda lakes (those dominated by Na+ ions and carbonate species) can concentrate precursors of RNA and membranes, such as phosphate, cyanide, and fatty acids. Subsequent assembly of RNA and membranes into cells is a long-standing problem because RNA function requires divalent cations, e.g. Mg2+, but Mg2+ disrupts fatty acid membranes. The low solubility of Mg-containing carbonates limits soda lakes to moderate Mg2+ concentrations (∼1 mM), so we investigated whether both RNAs and membranes function within these lakes. We collected water from Last Chance Lake and Goodenough Lake in Canada. Because we sampled after seasonal evaporation, the lake water contained ∼1 M Na+ and ∼1 mM Mg2+ near pH 10. In the laboratory, nonenzymatic, RNA-templated polymerization of 2-aminoimidazole-activated ribonucleotides occurred at comparable rates in lake water and standard laboratory conditions (50 mM MgCl2, pH 8). Additionally, we found that a ligase ribozyme that uses oligonucleotide substrates activated with 2-aminoimidazole was active in lake water after adjusting pH from ∼10 to 9. We also observed that decanoic acid and decanol assembled into vesicles in a dilute solution that resembled lake water after seasonal rains, and that those vesicles retained encapsulated solutes despite salt-induced flocculation when the external solution was replaced with dry-season lake water. By identifying compatible conditions for nonenzymatic and ribozyme-catalyzed RNA assembly, and for encapsulation by membranes, our results suggest that soda lakes could have enabled cellular life to emerge on Earth, and perhaps elsewhere.
Extracting intersectional stereotypes from embeddings: Developing and validating the Flexible Intersectional Stereotype Extraction procedure
Authors: Charlesworth Tessa E S , Ghate Kshitish , Caliskan Aylin , Banaji Mahzarin R 
Published: March 2024

Abstract
Social group–based identities intersect. The meaning of “woman” is modulated by adding social class as in “rich woman” or “poor woman.” How does such intersectionality operate at-scale in everyday language? Which intersections dominate (are most frequent)? What qualities (positivity, competence, warmth) are ascribed to each intersection? In this study, we make it possible to address such questions by developing a stepwise procedure, Flexible Intersectional Stereotype Extraction (FISE), applied to word embeddings (GloVe; BERT) trained on billions of words of English Internet text, revealing insights into intersectional stereotypes. First, applying FISE to occupation stereotypes across intersections of gender, race, and class showed alignment with ground-truth data on occupation demographics, providing initial validation. Second, applying FISE to trait adjectives showed strong androcentrism (Men) and ethnocentrism (White) in dominating everyday English language (e.g. White + Men are associated with 59% of traits; Black + Women with 5%). Associated traits also revealed intersectional differences: advantaged intersectional groups, especially intersections involving Rich, had more common, positive, warm, competent, and dominant trait associates. Together, the empirical insights from FISE illustrate its utility for transparently and efficiently quantifying intersectional stereotypes in existing large text corpora, with potential to expand intersectionality research across unprecedented time and place. This project further sets up the infrastructure necessary to pursue new research on the emergent properties of intersectional identities.
A content analysis of medication adherence material in patient educational resources about gout
Authors: Emad Yasaman , Derksen Christina , Petrie Keith J , Dalbeth Nicola 
Published: March 2024

Abstract

Objective
This study aimed to investigate how medication adherence is addressed in online gout resources in six countries. We investigated how often adherence was referred to, the strategies suggested to improve patient adherence, and the types of nonadherence that were targeted. We also examined the readability of the adherence material.

Methods
A content analysis was conducted on 151 online gout resources from medical and health organisations in six predominantly English-speaking countries. Two reviewers coded the content of the websites into categories (kappa 0.80). The analysis involved coding the resources for reasons for nonadherence, and adherence-promoting strategies. Flesch-Kincaid Reading Ease scores and word count were also computed.

Results
Out of 151 websites examined, 77 websites discussed medication adherence (51%), with intentional nonadherence being more prevalent than unintentional nonadherence. 67 websites targeted different types of nonadherence, including drug-specific concerns (50%), misconceptions of gout curability and the necessity of medication (16%), forgetfulness (16%), and other practical challenges (5%). Strategies to promote adherence were found in one-third of the websites, with medication education being the most prevalent strategy (17%), followed by healthcare provider engagement (13%) and memory aid strategies (6%). On average, about 11% of the words (89.27, SD = 76.35) in the entire document were focused on adherence. Difficult reading comprehension was found in one-fifth of adherence-related websites.

Conclusion
Findings reveal limited medication adherence coverage and narrow strategies in online gout resources. Improved adherence portrayal is needed for effective gout management through comprehensive strategies and clear, understandable information.
Trichoderma guizhouense NJAU4742 augments morphophysiological responses, nutrient availability and photosynthetic efficacy of ornamental Ilex verticillata
Authors: Lu Huixin , Zhou Peng , Li Fei , Wang Yanjie , Gu Jiaying , Wang Ying , Sun Shubin , Zhang Min , Wang Xiaowen 
Published: March 2024

Abstract
Winterberry holly (Ilex verticillata [L.] A. Gray), a deciduous shrub producing glossy bright red berries, is a valuable ornamental and medicinal plant with good market prospects. However, the growth and development of I. verticillata are significantly affected by various stresses, and environmentally hazardous agrochemicals are often used to mitigate them. Trichoderma spp., ubiquitous soil-borne eco-friendly plant growth-promoting fungi, are potent biostimulants and biofertilizers and viable alternatives to agrochemicals for healthy and sustainable agriculture. In this study, the temporal efficacy of different dosages of the filamentous fungus Trichoderma guizhouense NJAU4742 in promoting morphophysiological responses of I. verticillata and the physicochemical properties and enzymatic activities of the substrate were investigated. Different concentrations of the strain T. guizhouense NJAU4742 spore suspension (C [0%], T1 [5%, v/m], T2 [10%, v/m] and T3 [15%, v/m]) were injected in the substrate contained in a pot in which 1-year-old I. verticillata was planted for temporal treatment (15, 45 and 75 days) under open-air conditions. The beneficial effects of T2 and/or T3 treatment for a long duration (75 days) were evident on the different root, aerial and photosynthetic traits; total contents of nitrogen (N), phosphorus (P) and potassium (K) in different tissues and the physicochemical properties of the substrate and its enzymatic activities (urease and invertase). Overall, the study revealed the potency of strain T. guizhouense NJAU4742 as a sustainable solution to improve the growth and development and ornamental value of I. verticillata.
Development of a Telehealth Simulation Using Intraprofessional Collaboration
Authors: Rumsey Kimberly , Joy Shinu , More Dwayne , Cangelosi Morgan , Feng Juan , Touw Margaret 
Published: March 2024

Abstract
Telehealth allows access to high-quality, holistic patient care, including diagnosis, interventions, treatments, monitoring, and patient education. As the use of telehealth continues to increase, faculty considered the need for entry-level nursing students to be introduced to telehealth and its services. Faculty from the medical-surgical II and mental health courses developed a learning experience for students that blends concepts from both courses, as patients often present with multiple problems. The telehealth experience helped students utilize assessment skills, learn delegation, and connect concepts from two courses to provide care for a patient remotely.
A Phase 3, Single-arm Trial to Evaluate the Safety and Immunogenicity of a 20-Valent Pneumococcal Conjugate Vaccine in Healthy Children 15 Months Through <18 Years of Age
Authors: Meyer Jay , Silas Peter , Ouedraogo G. Laïssa , McElwee Kathleen , Keep Georgina , Trammel James , Peng Yahong , Scully Ingrid L. , Gruber William C. , Scott Daniel A. , Watson Wendy 
Published: March 2024

Background:
A 20-valent pneumococcal conjugate vaccine (PCV20), containing 13-valent PCV (PCV13) components and 7 additional polysaccharide conjugates, was developed to extend protection for pneumococcal disease. This phase 3 study assessed the safety and immunogenicity of PCV20 in children.

Methods:
In this single-arm study, children (≥15 months–<18 years of age) received 1 dose of PCV20. Children <5 years of age had ≥3 prior doses of PCV13; children ≥5 years were recruited regardless of previous PCV receipt. Serotype-specific IgG concentrations and opsonophagocytic activity (OPA) titers were measured before and 1 month after PCV20. Local reactions and systemic events, adverse events (AEs), serious AEs, and newly diagnosed chronic medical conditions were collected.

Results:
Of 839 enrolled participants, 831 (>99%) were vaccinated, and 819 (>97%) completed all study visits. Local reactions and systemic events were mostly mild to moderate in severity. No serious AEs were considered PCV20-related. IgG geometric mean fold rises (GMFRs) from before to 1 month after PCV20 ranged from 27.9–1847.7 (7 additional serotypes) and 2.9–44.9 (PCV13 serotypes) in children <5 years of age, and 10.5–187.7 (7 additional serotypes) and 4.3–127.9 (PCV13 serotypes) in children ≥5 years old. OPA GMFRs from before to 1 month after PCV20 ranged from 12.4–983.6 to 2.8–52.9 in children <5 years of age and from 11.5–499.0 to 5.3–147.9 in children ≥5 years of age.

Conclusions:
Among children ≥15 months through <18 years of age, PCV20 was well tolerated and induced robust responses to all 20 serotypes, supporting the use of PCV20 in children.
An integrated proteomics and metabolomics approach to assess graft quality and predict early allograft dysfunction after liver transplantation: a retrospective cohort study
Authors: Lin Yimou , Huang Haitao , Cao Jiaying , Zhang Ke , Chen Ruihan , Jiang Jingyu , Yi Xuewen , Feng Shi , Liu Jimin , Zheng Shusen , Ling Qi 
Published: March 2024

Background:
Early allograft dysfunction (EAD) is a common complication after liver transplantation (LT) and is associated with poor prognosis. Graft itself plays a major role in the development of EAD. We aimed to reveal the EAD-specific molecular profiles to assess graft quality and establish EAD predictive models.

Methods:
A total of 223 patients who underwent LT were enrolled and divided into training (n=73) and validation (n=150) sets. In the training set, proteomics was performed on graft biopsies, together with metabolomics on paired perfusates. Differential expression, enrichment analysis, and protein–protein interaction network were used to identify the key molecules and pathways involved. EAD predictive models were constructed using machine learning and verified in the validation set.

Results:
A total of 335 proteins were differentially expressed between the EAD and non-EAD groups. These proteins were significantly enriched in triglyceride and glycerophospholipid metabolism, neutrophil degranulation, and the MET-related signaling pathway. The top 12 graft proteins involved in the aforementioned processes were identified, including GPAT1, LPIN3, TGFB1, CD59, and SOS1. Moreover, downstream metabolic products, such as lactate dehydrogenase, interleukin-8, triglycerides, and the phosphatidylcholine/phosphorylethanolamine ratio in the paired perfusate displayed a close relationship with the graft proteins. To predict the occurrence of EAD, an integrated model using perfusate metabolic products and clinical parameters showed areas under the curve of 0.915 and 0.833 for the training and validation sets, respectively. It displayed superior predictive efficacy than that of currently existing models, including donor risk index and D-MELD scores.

Conclusions:
We identified novel biomarkers in both grafts and perfusates that could be used to assess graft quality and provide new insights into the etiology of EAD. Herein, we also offer a valid tool for the early prediction of EAD.
Cost-effectiveness analysis of endovascular versus open repair in patients with abdominal aortic aneurysm in Iran: a cross-sectional study
Authors: Nargesi Shahin , Abutorabi Ali , Mohamadi Yousef , Salimi Javad , Tajdini Masih , Alipour Vahid 
Published: March 2024

Objectives:
Abdominal aortic aneurysm (AAA) is one of the most important cardiovascular diseases, especially in the elderly. People with this disease are at risk of rupture of the abdominal aorta and death. The present study was conducted with the aim of analyzing the cost-effectiveness of endovascular repair compared to open surgery in AAA patients in Iran.

Methods:
A Markov chain model was developed based on the use of endovascular repair and open surgery. The base-case patient was defined as a 65-year-old man presenting with AAA diameter greater than 5 cm. The determination of costs was from the perspective of the public sector provider. QALY was used to calculate the effectiveness. Incremental cost-effectiveness ratio (ICER) and TreeAge software were used for cost-effectiveness analysis. The follow-up period was 10 years and the willingness to pay (WTP) was determined as three times the Gross domestic product (GDP) per capita.

Result:
At the end of year 10, the endovascular aneurysm repair (EVAR) strategy gained 1 318 313 559 Iranian Rial (IRR) (67 885.29$) in cost and 3.57 QALYs in effectiveness. In contrast, the use of the open surgery repair (OSR) strategy gained 1 186 761 858 IRR (61 111.16$) in cost and 3·32 QALYs in effectiveness. The incremental cost-effectiveness ratio, comparing EVAR versus OSR, was 53, 346, 3757 IRR (178.36$) per QALYs, which is lower than the proposed WTP, indicating that EVAR is more expensive and more effective. Based on the Monte Carlo simulation test, EVAR is the preferred strategy in 58.6% of the population.

Conclusion:
Endovascular repair has a relative superiority compared to open surgery, and the probability of the effectiveness of endovascular repair compared to open surgery does not change with increasing willingness to pay.
Determination of Maximum Tolerable Cold Ischemia Time in a Mouse Model of Cervical Heterotopic Uterus Transplantation
Authors: Luo Xin , Yu Shengnan , Liu Bing , Zheng Qisheng , Zhou Xin , An Ke , Zhong Jiaying , Wu Licheng , Dai Helong , Qi Zhongquan , Xia Junjie 
Published: March 2024

Background.
Uterus transplantation (UTx) is an emerging treatment for uterine factor infertility. Determining the maximum tolerable cold ischemia time is crucial for successful UTx. However, the limit for cold ischemia in the uterus is unclear. This study aimed to examine cold ischemia’s effects on mouse uteri and identify the maximum cold ischemia duration that uteri can endure.

Methods.
We systematically assessed the tolerance of mouse uteri to extended cold ischemia, 24 h, 36 h, and 48 h, using the cervical heterotopic UTx model. Multiple indicators were used to evaluate ischemia-reperfusion injury, including reperfusion duration, macroscopic examination, oxidative stress, inflammation, and histopathology. The function of transplants was evaluated through estrous cycle monitoring and embryo transfer.

Results.
Mouse uteri subjected to 48 h of cold ischemia exhibited significant delays and insufficiencies in reperfusion, substantial tissue necrosis, and loss of the estrous cycle. Conversely, uteri that underwent cold ischemia within 36 h showed long survival, regular estrous cycles, and fertility.

Conclusions.
Our study demonstrated that mouse uteri can endure at least 36 h of cold ischemia, extending the known limits for cold ischemia and providing a pivotal reference for research on the prevention and treatment of cold ischemic injury in UTx.
Developing Guidance for Donor Intervention Randomized Controlled Trials: Initial Discussions From the Canada-United Kingdom 2022 Workshop
Authors: Slessarev Marat , Bain Katie L. , Basmaji John , Blydt-Hansen Tom D. , Cooper Jessie , D’Aragon Frédérick , Del Sorbo Lorenzo , Evans Amy , Gordon Anthony C. , Klein Gail , Meade Maureen O. , Murphy Nicholas , Thomas Helen L. , Weiss Matthew J. , Weijer Charles , Harvey Dan 
Published: March 2024

Background.
Donor interventions, including medications, protocols, and medical devices administered to donors, can enhance transplantable organ quality and quantity and maximize transplantation success. However, there is paucity of high-quality evidence about their effectiveness, in part because of ethical, practical, and regulatory challenges, and lack of guidance about conduct of donor intervention randomized controlled trials (RCTs).

Methods.
With the vision to develop authoritative guidance for conduct of donor intervention RCTs, we convened a workshop of Canadian-United Kingdom experts in organ donation and transplantation ethics, research, and policy to identify stakeholders, explore unique challenges, and develop research agenda to inform future work in this promising field.

Results.
Donor intervention trials should consider perspectives of broad group of stakeholders including donors, transplant recipients, and their families; researchers in donation and transplantation; research ethics boards; and healthcare providers and administrators involved in donation and transplantation. Unique challenges include (1) research ethics (living versus deceased status of the donor at the time of intervention, intervention versus outcomes assessment in different individuals, harm-benefit analysis in donors versus recipients, consent, and impact on research bystanders); (2) outcome data standardization and linkage; and (3) regulatory and governance considerations.

Conclusions.
Donor intervention RCTs hold potential to benefit organ transplantation outcomes but face unique research ethics, outcome data, and regulatory challenges. By developing research agenda to address these challenges, our workshop was an important first step toward developing Canada-United Kingdom guidance for donor intervention RCTs that are poised to improve the quality and availability of transplantable organs.