bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neonatal and adult microglia cross‐present exogenous antigens
Authors: Beauvillain Celine , Donnou Sabrina , Jarry Ulrich , Scotet Mari , Gascan Hugues , Delneste Yves , Guermonprez Pierre , Jeannin Pascale , Couez Dominique 
Published: October 2007

AbstractSome observations have suggested that cells from the central nervous system (CNS) could present exogenous antigens on major histocompatibility complex (MHC) class I molecules to CD8+ T cells (a process called cross‐presentation). Microglia are the major myeloid immunocompetent cells of the CNS. When activated, following the injury of the nervous parenchyma, they become fully competent antigen‐presenting cells (APC) that prime CD4+ T lymphocytes. We therefore tested the cross‐presentation capacity of murine microglia. We report that a microglial cell line (C8‐B4), neonatal microglia, and interestingly adult microglia cross‐present soluble exogenous antigen (ovalbumin) to a OVA‐specific CD8+ T‐cell hybridoma and cross‐prime OVA‐specific naive OT‐1 CD8+ T cells. In both these cases, C8‐B4 and neonatal microglia cross‐present OVA as well as peritoneal macrophages. Although cross‐presentation by adult microglia is less efficient, it is increased by GM‐CSF and CpG oligodeoxynucleotide (ODN) stimulation. Using microglial cells either exposed to an inhibitor of proteasome, lactacystin, or purified from TAP−/− mice, we demonstrate that the microglia cross‐present antigen in proteasome‐ and TAP‐dependant pathways, respectively. Last, microglia purified from adult mice injected intracerebrally with OVA efficiently stimulate OVA‐specific CD8+ T cells, thereby showing that microglia take up and process exogenous antigen into MHC class I in vivo. This first demonstration of the cross‐presentation property of microglia offers novel therapeutic approaches to modulate CD8 T‐cell responses in the brain. © 2007 Wiley‐Liss, Inc.
A study of creative tension of engineering students in Korea
Authors: Chang Yoon , Kantola Jussi , Vanharanta Hannu 
Published: October 2007

AbstractThe aim of this research was to study the nature of creative tension of engineering students in South Korea. The creative tension was analyzed according to relevant competences in project managers' work role. Most of the subjects who participated in this study were part‐time students who worked as managers in manufacturing and industrial companies. The application used for collecting and analyzing data was the project managers' work‐role–based competence application, Cycloid. Data were collected on the Internet by self‐evaluation. The constructed competence model of the Cycloid application was added into the Evolute self‐evaluation system utilizing fuzzy logic. The application was able to identify students' current state and personal aims and the creative tension essential for their personal development. The Cycloid application can be utilized in developing the professional competencies of individuals, teams, and organizations. © 2007 Wiley Periodicals, Inc. Hum Factors Man 17: 511–520, 2007.
Toward the measure of organizational virtuality
Authors: Trzcieliński Stefan , Wojtkowski Wita 
Published: October 2007

AbstractIn this article we propose that organizational virtuality can be considered as a set of external as well as internal attributes. We focus on the attributes of internal virtuality, identify their possible dimensions, and refer to those as degrees of freedom. First we consider, in general terms, external and internal aspects of virtuality. Next we discuss organizational structures and introduce possible dimensions of virtuality that include the typology of the professional competencies. The dimensions of virtuality we introduce allow us to construct a multidimensional space of organizational virtuality. By means of this space we are able to convey the different degrees of organizational virtuality and offer some examples. In the final section of the article we test our constructs on real organizations and show a number of results concerning our measures of organizational virtuality. © 2007 Wiley Periodicals, Inc. Hum Factors Man 17: 575–586, 2007.
Non‐suicidal self‐injury: An introduction
Authors: Klonsky E. David 
Published: October 2007

AbstractThis issue of Journal of Clinical Psychology: In Session is devoted to the assessment and treatment of non‐suicidal self‐injury (henceforth self‐injury). In this introductory article, the author describes the scope of behaviors referenced by the term self‐injury, establishes the historical and current relevance of self‐injury for clinical practice, and summarizes the articles that appear in this issue. Self‐injury is the intentional destruction of body tissue without suicidal intent and for purposes not socially sanctioned. This issue addresses many aspects of self‐injury, including its prevalence, functions, assessment, and treatment. The articles feature case illustrations and treatment recommendations, and all have direct implications for clinical practice. © 2007 Wiley Periodicals, Inc. J Clin Psychol: In Session 63: 1039–1043, 2007.
Targeting emotion dysregulation in the treatment of self‐injury
Authors: Gratz Kim L. 
Published: October 2007

AbstractClinically useful definitions of emotion regulation with respect to deliberate self‐harm (referred to here as self‐injury) focus on adaptive ways of responding to emotional distress rather than on the control of emotions or dampening of emotional arousal. According to one such definition, emotion regulation is a multifaceted construct involving a) the awareness, understanding, and acceptance of emotions; b) ability to engage in goal‐directed behaviors, and inhibit impulsive behaviors, when experiencing negative emotions; c) the flexible use of situationally appropriate strategies to modulate the intensity and/or duration of emotional responses rather than to eliminate emotions entirely; and d) willingness to experience negative emotions as part of pursuing meaningful activities in life (Gratz & Roemer, 2004). This article addresses the role of emotion dysregulation in self‐injury and discusses two treatments for self‐injury that explicitly focus on increasing emotion regulation. These treatments are based on the premise that the reduction of emotion dysregulation will decrease the need for maladaptive behaviors that function to regulate emotions, such as self‐injury. A case illustration describing how one of these treatments (an acceptance‐based, emotion regulation group therapy) is used to treat self‐injury is provided. © 2007 Wiley Periodicals, Inc. J Clin Psychol: In Session 63: 1091–1103, 2007.
Psychodynamic treatments of self‐injury
Authors: Levy Kenneth N. , Yeomans Frank E. , Diamond Diana 
Published: October 2007

AbstractThe authors address psychodynamic therapies, particularly transference‐focused psychotherapy (TFP), in the treatment of patients who present with non‐suicidal self‐injury. In doing so, they briefly discuss various psychodynamic approaches with empirical evidence for their effectiveness. They describe TFP, including its treatment rationale, putative change mechanisms, and outcome research. They then present a case illustration of a patient with borderline personality disorder who engages in non‐suicidal self‐injury to demonstrate how TFP can be applied to such cases. © 2007 Wiley Periodicals, Inc. J Clin Psychol: In Session 63: 1105–1120, 2007.
The internet and self‐injury: What psychotherapists should know
Authors: Whitlock Janis , Lader Wendy , Conterio Karen 
Published: October 2007

AbstractThe Internet affords information gathering and sharing previously impossible. For individuals who practice self‐injury, this capacity allows rapid identification of others with shared history, experience, and practices. For many of those who self‐injure, the ability to find others like themselves reduces the isolation and loneliness that so often characterizes the behavior. For others, however, active participation in online communities may effectively substitute for the real work required to develop positive coping and healthy relationships. Our experience suggests that regular assessment of self‐injury Internet use is uncommon in therapeutic settings. Proliferation of self‐injury message boards, informational Web sites, blogs, and YouTube posts is a clinical challenge. In this article, we review the research on self‐injury and Internet use and then make a series of recommendations for clinicians. © 2007 Wiley Periodicals, Inc. J Clin Psychol: In Session 63: 1135–1143, 2007.
The effect of the prevailing weather on the statistics of atmospheric temperature inversions
Authors: Milionis A. E. , Davies T. D. 
Published: October 2007

AbstractThe unanimously accepted dependence of the static stability of the lower troposphere on the prevailing weather has, so far, not been expressed quantitatively. This work is the first systematic attempt at expressing this dependence quantitatively. Two weather classifications, an index expressing the activity of the atmospheric temperature inversion layers, and various other inversion statistics are considered for this purpose. Radiosonde data from Hemsby (UK) are used. Lamb's weather classification, which is used initially, shows clear differences in the statistics of inversions for different weather classes. The anticyclonic class is associated with the maximum activity, and the cyclonic class with the minimum activity. The weather class is also shown to affect the vertical variation of the activity of inversions. Differences in the activity of inversions due to the weather class are maximized in the layer 900–800 mb. Given that it is within this layer where the top of the atmospheric boundary layer is usually found, this result is of particular importance for air pollution modelling. An alternative weather classification is also used with the objective of associating inversion statistics not just to a particular weather type, but also to the physical reasons that are responsible for their formation. This classification shows that, in the absence of an anticyclone, the activity of inversions is rather independent of the prevailing weather pattern. However, when the anticyclonic category is also included, the differences become significant. As the results of this work express quantitatively the strong dependence of inversion statistics on the prevailing weather, they can be used for the creation of correction factors for many characteristics related to an inversion climatology (e.g. for the annual cycle of the activity of inversions). Such corrections are necessary in cases where the weather types in the study period do not reflect their frequency in the average climate. Copyright © 2007 Royal Meteorological Society
Relict rock glaciers and protalus lobes in the British Isles: implications for Late Pleistocene mountain geomorphology and palaeoclimate
Authors: Harrison Stephan , Whalley Brian , Anderson Edward 
Published: October 2007

AbstractMany relict rock glaciers and protalus lobes have been described in mountainous areas of the British Isles. This paper reviews their distribution, chronology, supposed origin and development, and places the research within current investigations and knowledge. Rock glaciers and protalus lobes are located in a number of different topographic locations and settings. They developed at the base of steep cliffs following the catastrophic failure of rock faces, at the base of scree slopes following the gradual accumulation of rock debris and in association with glaciers. Protalus lobes probably developed in response to the permafrost creep of talus material while rock glaciers formed through the deformation and sliding of large bodies of buried ice. Rock glaciers probably developed, or were last active, during the Younger Dryas, although the possibility exists that some of these landforms are Dimlington Stadial in age. The development of protalus lobes during the Younger Dryas suggests that precipitation levels were low and permafrost was widespread during this time. The lack of rock glaciers (sensu stricto) in the British Isles compared with other mountain areas is believed to be a consequence of the rock type and relative scarcity of weathered debris for their formation rather than a lack of suitable sites or appropriate environmental conditions. Copyright © 2007 John Wiley & Sons, Ltd.
Quaternary deformations along the ‘Engadine–Gruf tectonic system’, Swiss–Italian Alps
Authors: Tibaldi Alessandro , Pasquarè Federico A. 
Published: October 2007

AbstractThe Engadine Line (EL) is a seismically active fault in southeastern Switzerland. In the field we studied its western segment, presently not affected by seismicity but characterised by features suggesting neotectonic motions, and the coterminous Gruf Line. Uphill‐ and downhill‐facing scarps, offset rivers, non‐equilibrium hydrological conditions and aligned deep‐seated gravitational slope deformations are dominant in the western sector of the EL in the Inn Valley. Landform offsets and the most recent fault striations point to oblique left‐lateral strike‐slip. Close to the EL, at the Maloja Pass, a huge collapse beheaded the Inn Valley. Trench excavation with palaeoseismic analysis, stratigraphic correlations of Quaternary deposits and optically stimulated luminescence dating indicate that the collapse and faulting mostly occurred in the Late Pleistocene. In the Bregaglia Valley, the Gruf Line stretches along the southwestern extension of the EL. Six deep‐seated gravitational slope deformations developed along the Gruf Line and were dated to pre‐ and post‐Last Glacial Maximum times. We suggest that the western sector of the EL moved also in a Pleistocene time interval during which tectonic forces in the area were probably larger than at present, favouring local uplift, widespread gravity deformation, and retrogressive slope failure at the Inn Valley head. Copyright © 2007 John Wiley & Sons, Ltd.
Dissipative parabolic equations in locally uniform spaces
Authors: Arrieta J. M. , Cholewa J. W. , Dlotko Tomasz , Rodríguez–Bernal A. 
Published: October 2007

AbstractThe Cauchy problem for a semilinear second order parabolic equation ut = Δu + f (x, u,∇u), (t, x) ∈ ℝ+ × ℝN , is considered within the semigroup approach in locally uniform spaces $ {\dot W}^{s,p}_U $ (ℝN ). Global solvability, dissipativeness and the existence of an attractor are established under the same assumptions as for problems in bounded domains. In particular, the condition sf (s, 0) < 0, |s | > s0 > 0, together with gradient's “subquadratic” growth restriction, are shown to guarantee the existence of an attractor for the above mentioned equation. This result cannot be located in the previous references devoted to reaction‐diffusion equations in the whole of ℝN . (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A limit theorem for randomly stopped independent increment processes on separable metrizable groups
Authors: Becker–Kern Peter , Pap Gyula 
Published: October 2007

AbstractIn the spirit of the classical random central limit theorem a general limit theorem for random stopping in the scheme of infinitesimal triangular arrays on a separable metrizable group is presented. The approach incorporates and generalizes earlier results for normalized sequences of independent random variables on both separable Banach spaces and simply connected nilpotent Lie groups originated by Siegel and Hazod, respectively. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
On certain character sums over p ‐adic rings and their L ‐functions
Authors: Blache Régis 
Published: October 2007

AbstractIn this paper we present a new method for evaluating exponential sums associated to a restricted power series in one variable modulo pl , a power of a prime. We show that for sufficiently large l, these sums can be expressed in terms of Gauss sums. Moreover, we study the associated L ‐functions; we show that they are rational, then we determine their degrees and the weights as Weil numbers of their reciprocal roots and poles. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A Sturm–Liouville problem depending rationally on the eigenvalue parameter
Authors: Jonas Peter , Trunk Carsten 
Published: October 2007

AbstractWe consider the Sturm–Liouville problem (1.1) and (1.2) with a potential depending rationally on the eigenvalue parameter. With these equations a λ ‐linear eigenvalue problem is associated in such a way that L2‐solutions of (1.1), (1.2) correspond to eigenvectors of a linear operator. If the functions q and u are real and satisfy some additional conditions, the corresponding linear operator is a definitizable self‐adjoint operator in some Krein space. Moreover we consider the problem (1.1) and (1.3) on the positive half‐axis. Here we use results on the absense of positive eigenvalues for Sturm–Liouville operators to exclude critical points of the associated definitizable operator. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Global convoluted semigroups
Authors: Kostić M. , Pilipović S. 
Published: October 2007

AbstractGlobal exponentially bounded convoluted semigroups in Banach spaces are systematically treated with the help of Laplace transform. A perturbation theorem in this context is proved and some characterizations of the introduced class of analytic convoluted semigroups are obtained. Illustrative examples of generators of convoluted semigroups, including differential operators, are presented. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
p107 acts as a tumor suppressor in pRb‐deficient epidermis
Authors: Lara M. Fernanda , Santos Mirentxu , Ruiz Sergio , Segrelles Carmen , Moral Marta , Martínez‐Cruz Ana Belén , Hernández Pilar , Martínez‐Palacio Jesús , Lorz Corina , García‐Escudero Ramón , Paramio Jesús M. 
Published: October 2007

AbstractThe specific deletion of Rb gene in epidermis leads to altered proliferation and differentiation, but not to the development of spontaneous tumors. Our previous data have demonstrated the existence of a functional compensation of Rb loss by Rbl1 (p107) in as the phenotypic differences with respect to controls are intensified. However, the possible evolution of this aggravated phenotype, in particular in relationship with tumorigenesis, has not been evaluated due to the premature death of the double deficient mice. We have now investigated whether p107 can also act as a tumor suppressor in pRb‐deficient epidermis using different experimental approaches. We found spontaneous tumor development in doubly‐deficient skin grafts. Moreover, Rb‐deficient keratinocytes are susceptible to Ha‐ras‐induced transformation, and this susceptibility is enhanced by p107 loss. Further functional analyses, including microarray gene expression profiling, indicated that the loss of p107, in the absence of pRb, produces the reduction of p53‐dependent pro‐apoptotic signals. Overall, our data demonstrate that p107 behaves as a tumor suppressor in epidermis in the absence of pRb and suggest novel tumor‐suppressive roles for p107 in the context of functional p53 and activated Ras. © 2007 Wiley‐Liss, Inc.
Erratum: Deficiency in recapitulation of stage‐specific embryonic gene transcription in two‐cell stage cloned mouse embryos
Authors: Vassena Rita , Han Zhiming , Gao Shaorong , Latham Keith E. 
Published: October 2007

AbstractDue to a mathematical error, the cpm bound values for Figure 2 were calculated incorrectly. The correct figure is presented here.The original article to which this erratum refers was published in Molecular Reproduction and Development 2007;74(12):1548–1556.
Complete fatty degeneration of lumbar erector spinae muscles caused by a primary dysferlinopathy
Authors: Seror P. , Krahn M. , Laforet P. , Leturcq F. , Maisonobe T. 
Published: October 2007

AbstractMagnetic resonance imaging of the thoracolumbar spine showed complete fatty degeneration of the lumbar erector spinae muscles in a woman who had complained of chronic lower back pain for 5 years and of progressive weakness of the lower limbs for 1 year. Neuromuscular examination of the lower limbs showed no obvious anomaly, and there was no camptocormia. Serum creatine kinase levels were increased (six‐ to ninefold); electrodiagnostic examination revealed no activity at rest or during effort in the erector spinae muscles and was normal in proximal and distal muscles of the limbs. Muscle computed tomography revealed mild fatty degeneration of thigh and gastrocnemius muscles, and histopathology of the deltoid muscle showed dystrophic features and complete lack of dysferlin. Molecular analysis identified a homozygous disease‐causing mutation in the gene encoding dysferlin. Because there were no similar cases in the family, the final diagnosis was sporadic limb‐girdle muscular dystrophy type 2B. Overall, this case report shows that the lumbar and lower thoracic of erector spinae muscles may display complete fatty degeneration without the occurrence of camptocormia, with primary dysferlin deficiency as a possible cause. Muscle Nerve, 2007
On stabilized finite element methods for the Reissner–Mindlin plate model
Authors: Kouhia Reijo 
Published: October 2007

AbstractStabilized finite element formulation for the Reissner–Mindlin plate model is considered. Physical interpretation for the stabilization procedure for low‐order elements is established. Explicit interpolation functions for linear and bilinear stabilized MITC elements are derived. Some numerical examples including buckling and frequency analyses are presented. Copyright © 2007 John Wiley & Sons, Ltd.
Nursing staff attitudes towards patients with personality disorder
Authors: Webb Daniel , McMurran Mary 
Published: October 2007

AbstractBackground The Gwylfa Therapy Service is a specialist outpatient personality disorder (PD) service within Gwent Healthcare NHS trust. Among its key functions, the service is required to develop training procedures that improve the attitudes and capabilities of mental health staff working with patients with PD.Aim The aim was to assess Community Mental Health Team (CMHT) nurses' attitudes to patients with PD, using the Attitude to Personality Disorder Questionnaire (APDQ), and to compare their scores with published APDQ data for nurses and prison officers working with patients with PDs.Method Participants were nurses recruited from CMHTs (n = 88) and those who volunteered to attend a PD awareness workshop (n = 29). They completed the APDQ.Results CMHT nurses reported lower feelings of security, acceptance and purpose compared with all other groups, although at the same time they also reported higher levels of enjoyment in working with PD patients. CMHT nurses who volunteered to participate in an awareness workshop reported higher levels of enjoyment, security, acceptance and purpose when working with patients with PD compared to those who did not volunteer.Discussion CMHT nursing staff require help to feel safer, more accepting and more purposeful when working with patients with PD. Some of these issues may be addressed through the formulation of policies and good practice procedures, but staff also need to be trained for working with people with PD. The next step is to design suitable training and evaluate its effectiveness with respect to how it changes knowledge, attitudes and skills, and, eventually, how this benefits patients. Copyright © 2007 John Wiley & Sons, Ltd.