bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deubiquitinase PSMD7 facilitates pancreatic cancer progression through activating Nocth1 pathway via modifying SOX2 degradation
Authors: Luo Chen , Yu Yi , Zhu Jinfeng , Chen Leifeng , Li Dan , Peng Xingyu , Liu Zitao , Li Qing , Cao Qing , Huang Kai , Yuan Rongfa 
Published: March 2024

Abstract
Background
Ubiquitination is a critical post-translational modification which can be reversed with an enzyme family known as deubiquitinating enzymes (DUBs). It has been reported that dysregulation of deubiquitination leads to carcinogenesis. As a member of the DUBs family, proteasome 26 S subunit non-ATPase 7 (PSMD7) serves as an underlying tumour-promoting factor in multiple cancers. However, the clinical significance and biological functions of PSMD7 in pancreatic cancer (PC) remain unclear.

Results
In this study, we first reported frequent overexpression of PSMD7 in PC tissues, and high levels of PSMD7 were markedly linked to shorter survival and a malignant phenotype in PC patients. An array of in vitro and in vivo gain/loss-of-function tests revealed that PSMD7 facilitates the progression of PC cells. Additionally, we found that PSMD7 promotes PC cell progression by activating the Notch homolog 1 (Notch1) signalling. Interestingly, in PC cells, the inhibitory effect of PSMD7 knockdown on cellular processes was comparable to that observed upon Notch1 knockdown. Mechanistically, PSMD7 deubiquitinated and stabilised sex determining region Y (SRY)-box 2 (SOX2), a key mediator of Notch1 signalling. The stabilisation of SOX2, mediated by PSMD7, dramatically increased SOX2 protein levels, subsequently activating the Notch1 pathway. Finally, restoration of SOX2 expression abrogated the PSMD7-silenced antitumour effect.

Conclusions
Taken together, our work identifies and validates PSMD7 as a promoter of PC progression through augmentation of the Notch1 signalling pathway mediated by SOX2. This finding suggests that PSMD7 holds promise as a potential therapeutic target for the management of this refractory disease.
Predictive value of the Adult Comorbidity Evaluation 27 on adverse surgical outcomes and survival in elderly with advanced epithelial ovarian cancer undergoing cytoreductive surgery
Authors: Zhao Mengna , Gao Yang , Yang Junyuan , He Hao , Su Min , Wan Shimeng , Feng Xiaoye , Wang Hua , Cai Hongbing 
Published: March 2024

Abstract
Objective
We aimed to evaluate the ability of Adult Comorbidity Evaluation 27 (ACE-27) to predict perioperative outcomes and survival in elderly women with advanced epithelial ovarian cancer (AEOC) undergoing cytoreductive surgery.

Methods
We collected patients with AEOC in our hospital between January 1, 2012 and January 1, 2021. Patients younger than 65 years old or those with non-epithelial ovarian cancer were excluded. ACE-27 was applied retrospectively to assess comorbidities in the selected patients, who were then classified into two groups based on their ACE-27 scores: low ACE-27 score group (none to mild) and high ACE-27 score group (moderate to severe).

Results
A total of 222 elderly women with AEOC were included, of whom 164 patients accepted debulking surgery. Among those who have undergone surgery, Clavien–Dindo grade III + perioperative complications or unintended intensive care unit (ICU) admission occurred more often in patients of high ACE-27 score group, with statistically significant difference (odds ratio [OR]: 4.21, 95% confidence interval [CI], 1.28–14.35, p = 0.018). Further stratified analyses by age, BMI, FIGO stage and pathology also prove that OS of patients graded severe was shorter than patients graded none to moderate in cohort of age < 70, BMI < 25 kg/m2, FIGO III stage and pathology of serous, respectively. Kaplan–Meier survival curves analyzed by log-rank test showed that the overall survival (OS) of patients with severe comorbidities were shorter than with none to moderate (HR 3.25, 95%CI 1.55–6.79, p = 0.002).

Conclusions
Our findings demonstrate the ability of ACE-27 to predict grade III + perioperative complications or unintended ICU admission and survival in elderly patients with AEOC. This highlights the possibility for ACE-27 to play an instrumental role in identifying AEOC patients who are more susceptible to adverse surgical outcomes and have a poor survival rate and assisting in decisions regarding treatment.
Pathological characterization of pulmonary lesion and identification of associated bacteria and parasite infection in sheep and goat slaughtered at Dessie municipal abattoir, North-East Ethiopia
Authors: Teshale Nuredin , Amare Abadi , Feyisa Abdi , Abosse Jirata Shiferaw 
Published: March 2024

Abstract
Background
Lung is susceptible and vulnerable to many infectious and non-infectious agents. From this, a large number of specific and nonspecific diseases conditions can be diagnosed. A cross-sectional study design was conducted from December 2022 to May 2023 on major pulmonary lesion of sheep and goat slaughtered at Dessie municipal abattoir with the objective of characterizing the pulmonary pathological lesions, and isolating and identifying potential aerobic bacteria and parasite from pneumonic lung.

Materials and Methods
A total of 420 (302 sheep and 118 goats) were examined for gross lung lesions and histopathological investigation using standard techniques. Additionally, detailed pathological investigation was conducted on purposively selected lung lesions. Besides, pneumonic lesions were subjected to routine bacteriological and parasitological analysis.

Results
The overall abattoir prevalence of pulmonary abnormalities in sheep and goat was 81.2% (341/420). The common gross lesions encountered were Pneumonia (55.5%), emphysema (7.1%), atelectasis (3.3%), Hydatid cyst (4.3%), congestion (2.4%), haemorrhage (3.1%), Anthracosis (0.9%), adhesion (0.7%), and Bronchoectasis (0.7%) respectively. Pneumonia, hydatidosis, and pulmonary emphysema were significantly associated (p < 0.05) with animal age groups. Pneumonia was the most common disorder, accounting for 233 (55.5%). Dictyocaulus filaria (47.7%), Mullerius capillaries (23.2%) and Protostrongylus rufescens (17.16%) were isolated lung worm parasites; whereas E. coli (20.6%), Klebsiella Pneumoniae (12.7%), Mannheimia haemolytica (10.8%), Streptococcus species (4.9%), Staphylococcus aurous (7.8%) and Pasteurella multocida (2.9%), Pseudomonas (6.9%), Proteus (1.9%) and Cornybacterium (1%) were the isolated bacteria. Moreover, 18 (4.3%) Hydatid cysts were identified by cyst viability test. The pulmonary disorder of sheep and goats in the study are relatively high prevalent and posing great health and economic impacts.

Conclusion
Pulmonary infection with different agents is very common in the study areas. Feasible and affordable control measures and using latest diagnostic techniques like molecular detections of bacteria, viruses, and fungi, is necessary.
Persistent Opioid Use After Hospital Admission From Surgery in New Zealand: A Population-Based Study
Authors: Gong Jiayi , Jones Peter , Frampton Chris , Beyene Kebede , Chan Amy Hai Yan 
Published: March 2024

BACKGROUND:
Persistent opioid use (POU) is common after surgery and is associated with an increased risk of mortality and morbidity. There have been no population-based studies exploring POU in opioid-naïve surgical patients in New Zealand (NZ). This study aimed to determine the incidence and risk factors for POU in opioid-naïve patients undergoing surgery in all NZ hospitals.

METHOD:
We included all opioid-naïve patients who underwent surgery without a concomitant trauma diagnosis and received opioids after discharge from any NZ hospital between January 2007 and December 2019. Patients were considered opioid naïve if no opioids had been dispensed to them or if they did not have a prior diagnosis of an opioid-use disorder up to 365 days preceding the index date. The primary outcome was the incidence of POU, defined a priori as opioid use after discharge between 91 and 365 days. We used a multivariable logistic regression to identify risk factors for POU.

RESULTS:
We identified 1789,407 patients undergoing surgery with no concomitant diagnosis of trauma; 377,144 (21.1%) were dispensed opioids and 260,726 patients were eligible and included in the analysis. Of those included in the final sample, 23,656 (9.1%; 95% confidence interval [CI], 9.0%–9.2%) developed POU. Risk factors related to how opioids were prescribed included: changing to different opioid(s) after discharge (adjusted odds ratio [aOR], 3.21; 95% CI, 3.04–3.38), receiving multiple opioids on discharge (aOR, 1.37; 95% CI, 1.29–1.45), and higher total oral morphine equivalents (>400 mg) (aOR, 1.23; 95% CI, 1.23–1.45). Conversely, patients who were coprescribed nonopioid analgesics on discharge had lower odds of POU (aOR, 0.91; 95% CI, 0.87–0.95). Only small differences were observed between different ethnicities. Other risk factors associated with increased risk of POU included undergoing neurosurgery (aOR, 2.02; 95% CI, 1.83–2.24), higher comorbidity burden (aOR, 1.90; 95% CI, 1.75–2.07), preoperative nonopioid analgesic use (aOR, 1.65; 95% CI, 1.60–1.71), smoking (aOR, 1.44; 95% CI, 1.35–1.54), and preoperative hypnotics use (aOR, 1.35; 95% CI, 1.28–1.42).

CONCLUSIONS:
Approximately 1 in 11 opioid-naïve patients who were dispensed opioids on surgical discharge, developed POU. Potentially modifiable risk factors for POU, related to how opioids were prescribed included changing opioids after discharge, receiving multiple opioids, and higher total dose of opioids given on discharge. Clinicians should discuss the possibility of developing POU with patients before and after surgery and consider potentially modifiable risk factors for POU when prescribing analgesia on discharge after surgery.
Leg Lymphoedema After Inguinal and Ilio-Inguinal Lymphadenectomy for Melanoma: Results from a Prospective, Randomised Trial
Authors: Lee T. S. , Li I. , Peric B. , Saw R. P. M. , Duprat J. P. , Bertolli E. , Spillane J. B. , van Leeuwen B. L. , Moncrieff M. , Sommariva A. , Allan C. P. , de Wilt J. H. W. , Jones R. Pritchard- , Geh J. L. C. , Howle J. R. , Spillane A. J. 
Published: March 2024

Abstract
Background
The Evaluation of Groin Lymphadenectomy Extent for Melanoma (EAGLE FM) study sought to address the question of whether to perform inguinal (IL) or ilio-inguinal lymphadenectomy (I-IL) for patients with inguinal nodal metastatic melanoma who have no clinical or imaging evidence of pelvic disease. Primary outcome measure was disease-free survival at 5 years, and secondary endpoints included lymphoedema.

Methods
EAGLE FM was designed to recruit 634 patients but closed with 88 patients randomised because of slow recruitment and changes in melanoma management. Lymphoedema assessments occurred preoperatively and at 6, 12, 18, and 24 months postoperatively. Lymphoedema was defined as Inter-Limb Volume Difference (ILVD) > 10%, Lymphoedema Index (L-Dex®) > 10 or change of L-Dex® > 10 from baseline.

Results
Prevalence of leg lymphoedema between the two groups was similar but numerically higher for I-IL at all time points in the first 24 months of follow-up; highest at 6 months (45.9% IL [CI 29.9–62.0%], 54.1% I-IL [CI 38.0–70.1%]) and lowest at 18 months (18.8% IL [CI 5.2–32.3%], 41.4% I-IL [CI 23.5–59.3%]). Median ILVD at 24 months for those affected by lymphoedema was 14.5% (IQR 10.6–18.7%) and L-Dex® was 12.6 (IQR 9.0–17.2). There was not enough statistical evidence to support associations between lymphoedema and extent of surgery, radiotherapy, or wound infection.

Conclusions
Despite a trend for patients who had I-IL to have greater lymphoedema prevalence than IL in the first 24 months after surgery, our study’s small sample did not have the statistical evidence to support an overall difference between the surgical groups.
Multilevel Langevin Pathwise Average for Gibbs Approximation
Authors: Egéa Maxime , Panloup Fabien 
Published: March 2024

We propose and study a new multilevel method for the numerical approximation of a Gibbs distribution π on [Formula: see text], based on (overdamped) Langevin diffusions. This method relies on a multilevel occupation measure, that is, on an appropriate combination of R occupation measures of (constant-step) Euler schemes with respective steps [Formula: see text]. We first state a quantitative result under general assumptions that guarantees an ε-approximation (in an L2-sense) with a cost of the order [Formula: see text] or [Formula: see text] under less contractive assumptions. We then apply it to overdamped Langevin diffusions with strongly convex potential [Formula: see text] and obtain an ε-complexity of the order [Formula: see text] or [Formula: see text] under additional assumptions on U. More precisely, up to universal constants, an appropriate choice of the parameters leads to a cost controlled by [Formula: see text] (where [Formula: see text] and [Formula: see text] respectively denote the supremum and the infimum of the largest and lowest eigenvalue of [Formula: see text]). We finally complete these theoretical results with some numerical illustrations, including comparisons to other algorithms in Bayesian learning and opening to the non–strongly convex setting. Funding: The authors are grateful to the SIRIC ILIAD Nantes-Angers program, supported by the French National Cancer Institute [INCA-DGOS-Inserm Grant 12558].
Preventive central neck lymph node dissection as a stage in the treatment of papillary thyroid cancer
Authors: Tigrov М. S. , Yakovleva L. P. , Kropotov М. А. , Menshikova S. S. 
Published: March 2024

Relevance: The need of prophylactic cervical lymph node dissection for the detection of low grade thyroid cancer remains debatable since preoperative examination does not always allow determining the involvement of a group VI regional lymph collector.Objective: to evaluate the frequency of group VI nodes involvement with clinical N0–Nx based on the results of a morphological examination after performing a preventive central neck lymph node dissection.Materials and methods: the study included 295 patients who underwent surgery from 2016 to 2022 for papillary thyroid cancer with cT1–T2, N0–Nx. There were 11.5 % of men included (n = 34) and 88.5 % of women (n = 261). Of these, 40.7 % (n = 120) were less than 55 years old. All patients underwent surgical treatment which included thyroidectomy or hemithyroidectomy with cervical lymph node dissection.Results: The study included 295 patients with cT1 — 247 (83.7 %) and cT2 — 48 (16.3 %). Pathomorphological examination changed the T index in some patients: pT1 was found in 80.3 % of cases (n = 237); рТ2 — in 9.2 % (n = 27); рТ3 — in 10.5 % (n = 31). Central neck lymph nodes involvement was detected in 77 (26.1 %) out of 295 patients. There was a correlation between the frequency of metastases detection and the size of the primary tumor: 22.8 % (n = 54) of metastases with pT1, 33.3 % (n = 9) with pT2, and 45.2 % (n = 14) with pT3. Transient hypocalcemia was found in 32 % of patients with pT1, 69 % with pT2, and 84 % with pT3. Two patients had unilateral transient paresis of the larynx.Conclusions: Our analysis demonstrates that the preventive central neck lymph node dissection in patients with low grade thyroid cancer is an important component of surgical treatment, which allows to improve the treatment results with a possible subsequent reduction in the risk of distant progression. In this study 77 (26.1 %) of 295 patients had metastases in the lymph nodes of the central neck. The number of postoperative complications affecting the quality of life of patients was acceptable with 0.67 % of paresis of the larynx and 39 % of mild hypocalcemia.
Preserving the World Trade Organization’s Role Amid the Proliferation of Essential Security Interest
Authors: Nivia  
Published: March 2024

Abstract
International economic regime has been interrupted by recent disputes involving national security exception under Article XXI GATT. Along with the spirit of trade liberalization behind WTO’s establishment, the Panel conclude that it has jurisdiction on the matter. Nonetheless, this decision is opposed by several countries. This research aims to consider whether this approach is in line with GATT 1994’s purpose, namely to preserve the balance between trade liberalization and security interest of its Member States.Even though the answer is positive, the issue of compliance arises because of politically sensitive nature of security interest. Some States has expressed its refusal to comply with WTO’s decision on security interest exception. Hence, there is urgency to consider alternative forum to prevent all cases directly brought to litigation process. This research shows that WTO Panel’s approach to exercise its jurisdiction regarding the invocation of article XXI is indeed the best approach to maintain delicate balance between trade liberalization and security interest. However, aside of this adjudicative mechanism, there is proposal to establish National Security Committee to deal with states’ interest issue that may affect international trade system.
Keywords: essential security exception; World Trade Organization; dispute settlement mechanism.

Abstrak
Rezim ekonomi internasional terusik oleh beberapa kasus terakhir yang melibatkan pengecualian keamanan nasional di bawah artikel XXI GATT. Bersamaan dengan semangat pembentukan WTO, Panel menyimpulkan bahwa WTO memiliki yurisdiksi dan kasus tersebut dapat diperkarakan. Meskipun demikian, keputusan ini ditentang oleh beberapa negara. Penelitian ini bertujuan untuk menganalisis apakah pendekatan demikian selaras dengan tujuan GATT 1994, yakni menjaga keseimbangan antara liberalisasi dagang dan kepentingan keamanan negara anggotanya. Walaupun jawaban atas pertanyaan tersebut positif, isu kepatuhan muncul karena sensitivitas politis dari isu keamanan. Beberapa negara telah menunjukkan penolakannya untuk patuh pada kepputusan WTO dalam konteks kepentingan keamanan. Maka dari itu, terdapat urensi untuk menimbang alternatif forum lain untuk mencegah semua kasus dibawa ke dalam proses litigasi. Hasil penelitian menunjukkan bahwa pendekatan yang dilakukan WTO dengan menyatakan kewenangan mengadilinya atas artikel XXI memang merupakan pendekatan terbaik untuk menjaga keseimbangan antara liberalisasi perdagangan dan kepentingan keamanan negara anggota. Namun, di samping forum adjudikatif ini, terdapat proposal untuk membentuk National Security Committee untuk menangani isu keamanan negara yang mungkin memengaruhi sistem perdagangan internasional.

Kata Kunci: pengecualian keamanan esensial; World Trade Organization; mekanisme penyelesaian sengketa.
Analisis Legalitas Transaksional Binary Option di Indonesia
Authors: Nola Alfiona Kumala  
Published: March 2024

Abstract
The development of financial technology has given birth to a new financial transaction, namely Binary Options. Binary Options market their products as an investment that promises fixed profits, giving rise to public misconceptions as an investment. The Commodity Futures Trading Supervisory Agency has stated that Binary Options do not comply with the provisions of Indonesian laws and regulations. The aim of this research is to analyze the legality of Binary Option transactions. This research is legal research that uses a statutory approach and a conceptual approach. Binary Options have high risks because they are not registered on an exchange and are vulnerable to fraud. There is a need for comprehensive regulations relating to Binary Option transactions in Indonesia. This article will explain that Binary Options cannot be categorized as a form of investment. Furthermore, this article will explain that from a criminal law perspective, speculative Binary Option transactions can be categorized as a form of gambling.

Keywords: Binary Option, Commodity Future Exchange, Legality.

Abstrak
Perkembangan teknologi finansial dan instrumen keuangan telah melahirkan suatu transaksi keuangan baru yaitu Binary Option. Binary Option memasarkan produknya sebagai suatu investasi yang menjanjikan keuntungan tetap, sehingga menimbulkan miskonsepsi masyarakat sebagai investasi. Badan Pengawasan Perdagangan Berjangka Komoditi telah menyatakan bahwa Binary Option tidak sesuai dengan ketentuan peraturan perundang-undangan di Indonesia. Tujuan dari penelitian ini adalah menganalisis legalitas transaksional Binary Option. Penelitian ini merupakan penelitian hukum yang menggunakan pendekatan perundang-undangan dan pendekatan konseptual. Binary Option memiliki risiko yang tinggi karena tidak terdaftar di bursa dan rentan akan penipuan, perlu adanya regulasi yang komprehensif berkaitan dengan transaksi Binary Option di Indonesia. Artikel ini akan menjelaskan bahwa Binary Option tidak dapat dikategorikan sebagai suatu bentuk investasi baik dalam pasar modal maupun pasar perdagangan berjangka. Terlebih lanjut, artikel ini akan menjelaskan dalam perspektif hukum pidana, transaksi Binary Option yang spekulatif dapat dikategorikan sebagai suatu bentuk perjudian.

Kata Kunci: Binary Option, Perdagangan Berjangka Komoditas, Legalitas.
Hubungan Kadar D-dimer pada Ibu Hamil COVID-19 terhadap Kejadian Intrauterine Fetal Death (IUFD) di RSUD Dr. Moewardi
Authors: Sania Ainin Nuzula  , Prakosa Teguh , Setyawan Sigit , Abdurahman Laqif  
Published: March 2024

Pendahuluan: Pada kehamilan umumnya terdapat peningkatan aktivitas koagulasi secara fisiologis. Tingkat keparahan COVID-19 juga sejalan dengan aktivasi jalur koagulasi. Salah satu parameter koagulasi adalah D-dimer. Peningkatan kadar D-dimer pada ibu hamil COVID-19 berhubungan dengan terjadinya hiperkoagulabilitas. Perubahan koagulasi tersebut dapat berisiko terhadap kejadian Intrauterine Fetal Death (IUFD) karena terganggunya supply nutrisi dan oksigen dari ibu ke janin. Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan antara kadar D-dimer pada ibu hamil COVID-19 dengan kejadian Intrauterine Fetal Death (IUFD) di RSUD dr. Moewardi.
Metode: Penelitian ini dilaksanakan di RSUD dr. Moewardi dengan menggunakan pendekatan cross-sectional. Jumlah sampel yang diperlukan adalah 67 sampel yang terdapat dalam rekam medis sejak Maret 2020 sampai Maret 2023. Analisis data menggunakan SPSS dengan uji Chi Square.
Hasil: Hasil analisis bivariat pada 67 sampel ibu hamil COVID-19 yang terdiri dari 41 ibu hamil non IUFD dan 26 ibu hamil IUFD dengan menggunakan Chi Square didapatkan P-value sebesar 0,000 (P<0,05) dengan nilai Odds-Ratio 15,111.
Kesimpulan: Terdapat hubungan antara kadar D-dimer pada ibu hamil COVID-19 terhadap kejadian Intrauterine Fetal Death (IUFD).
In Search of Bracing’s New Crystal Ball
Authors: Pahys Joshua M. 
Published: March 2024

Update
This article was updated on May 14, 2024, because of a previous error. On page e17(1), the sentence that had read “Only those patients with optimal compliance with bracing (≥18 hours/day) were included, as opposed to those with ≥13 hours/day in the BrAIST study” now reads “Only those patients with optimal compliance with bracing (≥18 hours/day) were included, as opposed to those with an average of 12 hours/day in the BrAIST study.”
An erratum has been published: J Bone Joint Surg Am. 2024 Jun 19;106(12):e25(1).