bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Olefin Metathesis for the Synthesis of Constrained β‐Amino Esters from Norbornenes.
Authors: Nadany Adam E. , Mckendrick John E. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Unsaturated Organotrifluoroborates via Wittig and Horner—Wadsworth—Emmons Olefination.
Authors: Molander Gary A. , Figueroa Ruth 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Direct Preparation of (Z)‐1,3‐Enyne Systems with a TMS‐Propargylic Sulfone: Application of a One‐Pot Julia Olefination.
Authors: Bonini Carlo , Chiummiento Lucia , Videtta Valeria 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Convenient and Versatile Preparation of Unsymmetrical Bis‐metallic Isobutene Derivatives.
Authors: Driesschaert Benoit , Leroy Bernard 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Reactivity of Imide‐Derived Bisvinyl Phosphates. Reactivity of 2,6‐Disubstituted 1,4‐Dihydropyridines.
Authors: Mousset Deborah , Gillaizeau Isabelle , Sabatie Andrea , Bouyssou Pascal , Coudert Gerard 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Direct Access to Enantiomerically Enriched α‐Amino Phosphonic Acid Derivatives by Organocatalytic Asymmetric Hydrophosphonylation of Imines.
Authors: Pettersen Daniel , Marcolini Mauro , Bernardi Luca , Fini Francesco , Herrera Raquel P. , Sgarzani Valentina , Ricci Alfredo 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Microwave‐Assisted Cleavage of Phosphate, Phosphonate and Phosphoramide Esters.
Authors: Kumar G. D. Kishore , Saenz David , Lokesh G. L. , Natarajan Amarnath 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Fmoc‐Protected β‐Amino Alcohols and Peptidyl Alcohols from Fmoc‐Amino Acid/Peptide Acid Azides.
Authors: Babu Vommina V. Suresh , Kantharaju Kantharaju , Sudarshan Naremaddepalli S. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reactivity of per‐O‐Acetylated 1‐Thioglycosides and Glycosyl Sulfones Towards Chromium(II) Complexes in Aqueous Medium.
Authors: Micskei Karoly , Juhasz Zsuzsa , Ratkovic Zoran R. , Somsak Laszlo 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Convergent Stereocontrolled Synthesis of Substituted exo‐Glycals by Stille Cross‐Coupling of Halo‐exo‐glycals and Stannanes.
Authors: Gomez Ana M. , Barrio Aitor , Amurrio Inigo , Valverde Serafin , Jarosz Slawomir , Lopez J. Cristobal 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 2‐(5‐Azido‐5‐deoxy‐β‐D‐ribofuranosyl) ‐4‐methyl‐5‐nitro‐1,2,3‐triazole (X)
Authors: Banda Geetha , Srinivasulu D. , Ugandhar V. , Chakravarthy I. E. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
epi‐Aszonalenins A, B, and C from Aspergillus novofumigatus.
Authors: Rank Christian , Phipps Richard Kerry , Harris Pernille , Frisvad Jens Christian , Gotfredsen Charlotte Held , Larsen Thomas Ostenfeld 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
N‐Carboxamido‐staurosporine (I) and Selina‐4(14),7(11)‐diene‐8,9‐diol (II), New Metabolites from a Marine Streptomyces sp.
Authors: Wu Shao Jie , Fotso Serge , Li Fuchao , Qin Song , Kelter Gerhard , Fiebig Heinz H. , Laatsch Hartmut 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Stereoselective Synthesis of (‐)‐Trachelanthamidine (IV) via Palladium‐Catalyzed Intramolecular Allylation.
Authors: Craig Donald , Hyland Christopher J. T. , Ward Simon E. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Total Synthesis of (.+‐.)‐Mitorubrinic Acid.
Authors: Marsini Maurice A. , Gowin Kristoffer M. , Pettus Thomas R. R. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Total Synthesis of (‐)‐Panacene and Correction of Its Relative Configuration.
Authors: Boukouvalas John , Pouliot Martin , Robichaud Joel , MacNeil Stephen , Snieckus Victor 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemical Synthesis of ComX Pheromone and Related Peptides Containing Isoprenoidal Tryptophan Residues.
Authors: Okada Masahiro , Sato Isao , Cho Soo Jeong , Dubnau David , Sakagami Youji 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hypocrellin D, a Cytotoxic Fungal Pigment from Fruiting Bodies of the Ascomycete Shiraia bambusicola
Authors: Fang Li‐Zhen , Qing Chen , Shao Hong‐Jun , Yang Yi‐Dong , Dong Ze‐Jun , Wang Fei , Zhao Wei , Yang Wan‐Qiu , Liu Ji‐Kai 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Photorefractive Cyclometalated Complexes
Authors: Termine R. , Talarico M. , Aiello I. , Dattilo D. , Pucci D. , Ghedini M. , Golemme A. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Recent Developments in the Syntheses of the Epothilones and Related Analogues
Authors: Watkins E. Blake , Chittiboyina Amar G. , Avery Mitchell A. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Five‐Membered Ring Systems: Thiophenes and Se/Te Analogues
Authors: Seshadri Venkataramanan , Selampinar Fatma , Sotzing Gregory A. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Progress of Solid‐Phase Microextraction Coatings and Coating Techniques
Authors: Jiang Guibin , Huang Minjia , Cai Yaqi , Lv Jianxia , Zhao Zongshan 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
NMR of Conotoxins: Structural Features and Analysis of Chemical Shifts of Posttranslationally Modified Amino Acids
Authors: Marx Ute C. , Daly Norelle L. , Craik David J. 
Published: November 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Adenosine triphosphate‐binding cassette B1 (ABCB1) (multidrug resistance 1) G2677T/A gene polymorphism is associated with high risk of lung cancer
Authors: Gervasini Guillermo , Carrillo Juan Antonio , Garcia Montserrat , San Jose Carmen , Cabanillas Agustin , Benitez Julio 
Published: November 2006

AbstractBACKGROUND.P‐glycoprotein (P‐gp) is a transmembrane transporter that is encoded by the adenosine triphosphate‐binding cassette B1 (ABCB1) (multidrug resistance 1) gene, which plays a role in cell defense against environmental attacks, like those generated by xenobiotics. P‐gp is expressed in the lung, where it has been suggested to transport these compounds from the interstitium into the lumen.METHODS.Two functional ABCB1 polymorphisms were examined, G2677T/A (in exon 21) and C3435T (in exon 26), in a group of lung cancer patients and in a control group.RESULTS.Whereas 3435T allelic and genotype frequencies were unchanged between both study groups, lung cancer patients showed higher frequency of the 2677T variant allele compared with the control group (0.67 vs. 0.43; P < .001; odds ratio, [OR], 2.6; 95% confidence interval [95% CI], 1.7–4.0). Among the histologic tumor types that were included in the study, squamous cell carcinoma was associated most strongly with the presence of the 2677T allele (OR, 3.92; 95% CI, 2.2–6.9) and especially was associated with the 2677 TT genotype (OR, 6.75; 95% CI, 3.0–15.2). In a haplotype analysis, homozygous wild‐type alleles were classified as genotype A, heterozygous alleles were classified as genotype B, and homozygous mutant allele were classified as genotype C both in exon 21 (first letter) and in exon 26 (second letter) loci. The haplotype CB displayed the highest association with lung cancer (OR, 18.09; 95% CI, 2.4–139.2).CONCLUSIONS.The current results taken together suggest that, aside from other known causes of lung cancer, such as tobacco smoke, the existence of polymorphisms in the ABCB1 gene and, specifically, the presence of the G2677T mutation can be crucial in conferring susceptibility to lung cancer. Further studies comprising larger populations are needed to confirm these preliminary findings. Cancer 2006. © 2006 American Cancer Society.
Prolonged follow‐up after initial therapy with 2‐chlorodeoxyadenosine in patients with indolent non‐Hodgkin lymphoma
Authors: Blum Kristie A. , Johnson Jeffrey L. , Niedzwiecki Donna , Piro Lawrence D. , Saven Alan , Peterson Bruce A. , Byrd John C. , Cheson Bruce D. ,   for the Cancer and Leukemia Group B
Published: November 2006

AbstractBACKGROUND.The objective of this study was to determine the efficacy and toxicity of 2‐chlorodeoxyadenosine (2‐CdA) in patients with untreated, indolent non‐Hodgkin lymphoma (NHL).METHODS.For this multicenter, single‐arm, Phase II study, 44 patients with treatment‐naive, stage III or IV, indolent NHL (International Working Formulation subtypes A, B, and C) were enrolled. Patients received 0.14 mg/kg per day of 2‐CdA as a 2‐hour bolus infusion for 5 consecutive days every 28 days until maximal response or a total of 6 cycles.RESULTS.Thirty‐eight patients were eligible for response evaluation. The overall response rate was 100% (95% confidence interval [95% CI], 90.8–100%), and the complete response rate was 31.6% (95% CI, 17.5–48.7%). In the intent‐to‐treat population, the median failure‐free survival was 2.0 years (95% CI, 1.3–3.4 years), and the overall survival rate was 7.0 years (95% CI, 4.3–9.4 years). Six patients had sustained remissions that lasted a median of 8.7 years (range, from 5.9 years to ≥11 years). Although 68% of patients experienced at least 1 grade 3 or 4 event, consisting primarily of myelosuppression, severe infections were rare, with only 8 grade 3 infections. Four late malignancies (prostate adenocarcinoma, ductal carcinoma in situ, and myelodysplasia) and 4 patients with large cell transformation were reported.CONCLUSIONS.2‐CdA is an active, well‐tolerated therapy for patients with untreated, indolent NHL. Cancer 2006. © 2006 American Cancer Society.
Productivity and performance through components: the ASCI Sweep3D application
Authors: Yoon Young , Browne James C. , Crocker Mathew , Jain Samit , Mahmood Nasim 
Published: November 2006

AbstractThis paper is a case study of the effectiveness of component‐oriented development for enhancing both productivity and performance for parallel programs. A process for converting monolithic applications into semantically composable components is described. The supporting software, the P‐COM2 compositional compiler, is briefly described. The componentized version of Sweep3D is described. Productivity is illustrated by composing different instances of the Sweep3D code through automated composition of components using P‐COM2. These instances, each of which targets improving performance for some execution environment or problem case, are examples of a family of instances which are composable from a modest set of components. It is found that customization of componentized codes by component‐level adaptation may yield substantial performance improvement for specific execution environments. We identify and explain some of the benefits of component‐oriented development for high‐performance parallel systems. Copyright © 2006 John Wiley & Sons, Ltd.
Synthesis and Characterisation of Dinuclear Nickel(II) and Cadmium(II) Complexes of N‐Alkylated Derivatives of Hexaazadithiophenolate Macrocycles
Authors: Gressenbuch Mathias , Kersting Berthold 
Published: November 2006

AbstractThe effect of N‐alkylation on the ligating properties of the Robson‐type 24‐membered hexaazadithiophenolate macrocycle H2L1 [13,27‐bis(tert‐butyl)‐3,6,9,17,20,23‐hexaazatricyclo[23.3.111,15]triaconta‐1(28),11,13,15(30),25,26‐hexaene‐29,30‐dithiol] has been examined. Two new derivatives (H2L3 and H2L4) of H2L1 have been prepared. H2L3 is a dimethylated derivative of H2L1 and H2L4 is a tetraethylated derivative of H2L3. A series of complexes of the type [(LR)MII2(μ‐Cl)]+ [R = 1, M = Cd (10), R = 3, M = Ni (8), M = Cd (12), R = 4, M = Ni (9), M = Cd (13)] have been prepared and structurally characterised. The X‐ray crystal structure determination of these dioctahedral complexes with an N3M(S)2(μ‐Cl)MN3 core structure has revealed two conformations of the supporting ligands. In 8, 9, 10 and 12 the ligands adopt a folded Cs‐symmetric conformation of type A whereas in the cadmium complex 13 the alternative C2v‐symmetric “bowl‐shaped” conformation (type B) is present. A structural comparison has allowed us to determine the factors that determine the ligand conformations. It has been established that the ligand conformations adopted depend not only on the co‐ligand but also on the metal ion radius and the N‐alkylation grade. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Synthesis, Structures and Comparison of Neutral Complexes Formed by2‐(2′‐Pyridyl)indole and d6 Transition Metals
Authors: Neumann Bernd , Krinninger Christoph , Lorenz Ingo‐Peter 
Published: November 2006

Abstract2‐(2′‐Pyridyl)indole acts as an N,N‐bidentate ligand when deprotonated and forms (1‐amido‐4‐imine)metallacycles with ReI, RuII, RhIII and IrIII. The crystal structures of 2‐(2′‐pyridyl)indole and the complexes [Re(C13H9N2)(CO)2(PPh3)2], [Ru(C13H9N2)(η6‐C6Me6)Cl], [Rh(C13H9N2)(η5‐C5Me5)Cl] and [Ir(C13H9N2)(η5‐C5Me5)Cl] are presented and their spectra discussed. This provides a foundation for the increased use of this ligand, which is a prototype of a monoanionic, bidentate N,N‐chelating ligand. The introduction of negatively charged N,N‐bidentate ligands can increase the possibility of synthesising complexes tailored to catalysis and other applications. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Planar Chiral (Arene)chromiumcarbonyl‐Substituted Propargyl Cations – A Spectroscopic and Computational Study
Authors: Netz Astrid , Drees Markus , Strassner Thomas , Müller Thomas J. J. 
Published: November 2006

AbstractPlanar chiral (arene)Cr(CO)3‐substituted propargyl cations can be diastereoselectively generated from propargyl acetates with the use of strong Lewis acids, and they have been structurally characterized by UV/Vis and 13C NMR spectroscopy. At low temperatures (<–65 °C) the s‐cis isomer is exclusively obtained as a product of a kinetically controlled ionization. DFT studies on the structure of the propargyl cations and on the Cipso–Cα bond rotation to give the thermodynamically favored s‐trans isomer reveal that the substitution pattern at the γ‐propargyl position has a stronger impact on the height of the rotational barrier than the substituent on the complexed aryl ring. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Regioselective Base‐Promoted Nucleophilic Ring Opening of Spirocyclic 2,6‐Dioxopiperazines: Synthesis of N‐(1‐Carboxycyclohexyl)amino Acid Derivatives
Authors: González‐Vera Juan A. , García‐López M. Teresa , Herranz Rosario 
Published: November 2006

AbstractAmino acid derived spirocyclic 2,6‐dioxopiperazines are easily and regioselectively opened by base‐promoted nucleophilic attack of hydroxide or H2O on the less crowded carbonyl group at C‐6 to give N‐(1‐carbamoylcyclohexyl)amino acid derivatives. However, the imide group of the 2,6‐dioxopiperazine ring is rather unreactive toward alcohols, alkoxides, and amines. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Construction of Highly Substituted Stereodefined Dienes by Cross‐Coupling of α‐Allenic Acetates
Authors: Schneekloth John S. , Pucheault Mathieu , Crews Craig M. 
Published: November 2006

AbstractThe assembly of highly substituted dienes remains a challenge for organic chemistry. This work represents a strategyfor the construction of highly substituted 1,3‐dienes by meansof a Tsuji–Trost cross coupling between α‐allenic acetates and organozinc reagents. The reaction is high yielding, and installs a trisubstituted olefin with E/Z selectivities up to 95:5 favoring the (E) product. A cheap, commercially available palladium precatalyst and a ligand are used to control theE/Z selectivity. Furthermore, an interesting reversal in selectivity is noted in which appropriate choice of ligand may be used to control the outcome of the reaction and favor the (Z) product. Thirteen examples are described, highlighting the substrate scope of the reaction. It is hoped that the straightforward reaction conditions and high selectivity will make this reaction of broad use in natural product chemistry. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Synthesis of Alaninyl and N‐(2‐Aminoethyl)glycinyl Amino Acid Derivatives Containing the Green Fluorescent Protein Chromophore in Their Side Chains for Incorporation into Peptides and Peptide Nucleic Acids
Authors: Stafforst Thorsten , Diederichsen Ulf 
Published: November 2006

AbstractArtificial amino acids carrying either the chromophore of the Green Fluorescent Protein (GFP) or a modification as their side chains have been synthesized: Boc‐protected alaninyl derivatives and Fmoc‐protected N‐(2‐aminoethyl)glycine‐functionalized amino acids were obtained and could be applied in solid‐phase peptide synthesis. The incorporation of the GFP chromophore into N‐(2‐aminoethyl)glycine‐PNA was achieved and fluorescence was studied as a function of hybridization with complementary DNA. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Asymmetric Synthesis of Antithrombotic Agents M58163 and M58169: Dynamic Kinetic Resolution in Amide Formation Catalyzed by La‐Linked BINOL Complex
Authors: Saitoh Fumihiko , Nishida Hidemitsu , Mukaihira Takafumi , Aikawa Kohsuke , Mikami Koichi 
Published: November 2006

AbstractThe first asymmetric syntheses of antithrombotic agents M58163 and M58169 are reported. Dynamic kinetic resolution is observed in the amide formation step. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Novel Building Blocks: 1‐Aryl‐2‐chloro‐1‐ethoxyethenes – Preparations and Transformations
Authors: Yoshimatsu Mitsuhiro , Sakai Miho , Moriura Eri 
Published: November 2006

AbstractWe described here a simple method for the preparation of 1‐aryl‐2‐chloro‐1‐ethoxyethenes 2a–u, which are prodrugs for Alzheimer's disease, by the reaction of dichloroacetaldehyde diethyl acetal with various aryl and alkenyllithium compounds in high yields. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Patterning microbeads inside poly(dimethylsiloxane) microfluidic channels and its application for immobilized microfluidic enzyme reactors
Authors: Zhang Qing , Xu Jing‐Juan , Chen Hong‐Yuan 
Published: November 2006

AbstractWe propose a convenient and reliable approach for immobilizing microbeads on poly(dimethylsiloxane) (PDMS) microchips. It is built upon a simple fabrication procedure of PDMS chip through directly printing the master with an office laser printer which was described in our previous work (J. Chromatogr. A 2005, 1089, 270–275). On the printed toners used as the positive relief of the master, microbeads were immobilized by a thermal treatment and then transferred to the surface of the microchip by direct molding of the prepolymer on the master. With this approach, the region‐selective immobilization of microbeads and the fabrication of PDMS microchips can be accomplished at the same time. Then, using these microbeads as supports, further modification with enzyme was achieved. Surface characteristics of the microbeads‐modified PDMS microchannels were investigated with scanning electron microscope, atomic force microscope, and inverse fluorescence microscope. The electrokinetic properties of the native PDMS and the modified PDMS chips were also compared. Based on this approach, an immobilized glucose oxidase (GOD) reactor was constructed and the reaction using glucose as substrate was studied. All these experiments aim to show that the proposed approach may have a good potential in the study of biochemistry and other related areas.