bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suppression of T cell costimulator ICOS by Δ9-tetrahydrocannabinol
Authors: Lu Haitian , Kaplan Barbara L F , Ngaotepprutaram Thitirat , Kaminski Norbert E 
Published: November 2008

AbstractInducible costimulator (ICOS), a prototypic T cell costimulator, is induced on activated T cells. ICOS regulates T cell activation and Th cell differentiation and is principally involved in humoral immune responses. Previous work showed that T cell accessory function is modulated by the plant-derived cannabinoid, delta-9-tetrahydrocannabinol (Δ9-THC). In light of an emerging role by ICOS in T cell-mediated immunity, the objective of this study was to investigate the effect of Δ9-THC on ICOS in activated mouse T cells. Induction of ICOS mRNA levels by phorbol ester (PMA) plus ionomycin (Io) activation in mouse splenocytes was attenuated by Δ9-THC in a concentration-related manner. Similar results were obtained in the mouse T cell line, EL4.IL-2. Anti-CD3/CD28 induced ICOS expression on CD4+ splenic T cells, which was suppressed by Δ9-THC in a time- and concentration-related manner. The PMA/Io-induced icos promoter luciferase reporter activity was also down-regulated by Δ9-THC, suggesting that the suppression of ICOS expression by Δ9-THC occurs at the transcriptional level. Moreover, transcriptional activation of the NFAT was also down-regulated by Δ9-THC as shown by a NFAT luciferase reporter assay, which is consistent with a putative role of NFAT in regulating ICOS expression. Collectively, Δ9-THC suppresses ICOS expression in activated T cells, and this suppression may be related, in part, to its modulation of NFAT signaling. The emerging role of ICOS in a wide range of immune-related diseases also suggests that it may represent a potential therapeutic target, which could be modulated by cannabinoid compounds.
Endogenous Hepatocyte Growth Factor Is a Niche Signal for Subventricular Zone Neural Stem Cell Amplification and Self-Renewal
Authors: Nicoleau Camille , Benzakour Omar , Agasse Fabienne , Thiriet Nathalie , Petit Jérôme , Prestoz Laetitia , Roger Michel , Jaber Mohamed , Coronas Valérie 
Published: November 2008

Abstract
Neural stem cells persist in the adult mammalian brain, within the subventricular zone (SVZ). The endogenous mechanisms underpinning SVZ neural stem cell proliferation, self-renewal, and differentiation are not fully elucidated. In the present report, we describe a growth-stimulatory activity of liver explant-conditioned media on SVZ cell cultures and identify hepatocyte growth factor (HGF) as a major player in this effect. HGF exhibited a mitogenic activity on SVZ cell cultures in a mitogen-activated protein kinase (MAPK) (ERK1/2)-dependent manner as U0126, a specific MAPK inhibitor, blocked it. Combining a functional neurosphere forming assay with immunostaining for c-Met, along with markers of SVZ cells subtypes, demonstrated that HGF promotes the expansion of neural stem-like cells that form neurospheres and self-renew. Immunostaining, HGF enzyme-linked immunosorbent assay and Madin-Darby canine kidney cell scattering assay indicated that SVZ cell cultures produce and release HGF. SVZ cell-conditioned media induced proliferation on SVZ cell cultures, which was blocked by HGF-neutralizing antibodies, hence implying that endogenously produced HGF accounts for a major part in SVZ mitogenic activity. Brain sections immunostaining revealed that HGF is produced by nestin-expressing cells and c-Met is expressed within the SVZ by immature cells. HGF intracerebroventricular injection promoted SVZ cell proliferation and increased the ability of these cells exposed in vivo to HGF to form neurospheres in vitro, whereas intracerebroventricular injection of HGF-neutralizing antibodies decreased SVZ cell proliferation. The present study unravels a major role, both in vitro and in vivo, for endogenous HGF in SVZ neural stem cell growth and self-renewal.
The Epidemiology of Suicidal Behaviour in Australia
Authors: Hetzel Basil S. 
Published: November 2008

There has been a striking rise in the suicide rate in Australia over the past 20 years. Between 1955 and 1965, the rate has risen from 15.1 per 100,000 in men to 18.8 and from 5.4 per 100,000 in women to 10.8 (W.H.O.). This rise is largely due to increase in self-poisoning. Studies of Victorian data from the last 20 years reveal that the rise is particularly evident in men between the ages of 25 and 44 and in women under the age of 35 and over the age of 55. It is much more evident in the metropolis of Melbourne, suggesting the importance of social factors. There has also been a two to three times increase in cases of attempted suicide due to self-poisoning with various commonly prescribed drugs presenting in casualty departments of general hospitals since 1955. Detailed study of 150 cases seen at the Alfred Hospital in 1969 reveals the predominance of women, the importance of interpersonal, marital and family difficulties, and of social isolation, as well as past parental deprivation. These findings indicate the desirability of restricting sedative drug prescriptions, the need for befriending services in the city, a knowledge of social services available, and education for married and family life. Better training in developmental and social psychology for medical practitioners, nurses, ministers of religion and the police will also help in prevention.
Efficacy and safety of motor cortex stimulation for chronic neuropathic pain: critical review of the literature
Authors: Fontaine Denys , Hamani Clement , Lozano Andres 
Published: November 2008

Object
The authors systematically reviewed the published literature to evaluate the efficacy of and adverse effects after motor cortex stimulation (MCS) for chronic neuropathic pain.

Methods
A search of the PubMed database (1991–2006) using the key words “motor cortex,” “stimulation,” and “pain” yielded 244 articles. Only original nonduplicated articles were selected for further analysis; 14 studies were identified for critical review. All were series of cases and none was controlled. The outcomes in 210 patients were assessed and expressed as the percentage of patients that improved with the procedure.

Results
A good response to MCS (pain relief ≥ 40–50%) was observed in ~ 55% of patients who underwent surgery and in 45% of the 152 patients with a postoperative follow-up ≥ 1 year. Visual analog scale scores were provided in 76 patients, revealing an average 57% improvement in the 41 responders. A good response was achieved in 54% of the 117 patients with central pain and 68% of the 44 patients with trigeminal neuropathic pain. Adverse effects were reported in 10 studies, including 157 patients. Infections (5.7%) and hardware-related problems (5.1%) were relatively common complications. Seizures occurred in 19 patients (12%) in the early postoperative period, but no chronic epilepsy was reported.

Conclusions
The results of the authors' review of the literature suggest that MCS is safe and effective in the treatment of chronic neuropathic pain. Results must be considered with caution, however, as none of the trials were blinded or controlled. Studies with a better design are mandatory to confirm the efficacy of MCS for chronic neuropathic pain.
Aβ amyloid and glucose metabolism in three variants of primary progressive aphasia
Authors: Rabinovici Gil D. , Jagust William J. , Furst Ansgar J. , Ogar Jennifer M. , Racine Caroline A. , Mormino Elizabeth C. , O'Neil James P. , Lal Rayhan A. , Dronkers Nina F. , Miller Bruce L. , Gorno‐Tempini Maria Luisa 
Published: November 2008

AbstractObjectiveAlzheimer's disease (AD) is found at autopsy in up to one third of patients with primary progressive aphasia (PPA), but clinical features that predict AD pathology in PPA are not well defined. We studied the relationships between language presentation, Aβ amyloidosis, and glucose metabolism in three PPA variants using [11C]‐Pittsburgh compound B ([11C]PIB) and [18F]‐labeled fluorodeoxyglucose positron emission tomography ([18F]FDG‐PET).MethodsPatients meeting PPA criteria (N = 15) were classified as logopenic aphasia (LPA), progressive nonfluent aphasia (PNFA), or semantic dementia (SD) based on language testing. [11C]PIB distribution volume ratios were calculated using Logan graphical analysis (cerebellar reference). [18F]FDG images were normalized to pons. Partial volume correction was applied.ResultsElevated cortical PIB (by visual inspection) was more common in LPA (4/4 patients) than in PNFA (1/6) and SD (1/5) (p < 0.02). In PIB‐positive PPA, PIB uptake was diffuse and indistinguishable from the pattern in matched AD patients (n = 10). FDG patterns were focal and varied by PPA subtype, with left temporoparietal hypometabolism in LPA, left frontal hypometabolism in PNFA, and left anterior temporal hypometabolism in SD. FDG uptake was significant asymmetric (favoring left hypometabolism) in PPA (p < 0.005) but not in AD.InterpretationLPA is associated with Aβ amyloidosis, suggesting that subclassification of PPA based on language features can help predict the likelihood of AD pathology. Language phenotype in PPA is closely related to metabolic changes that are focal and anatomically distinct between subtypes, but not to amyloid deposition patterns that are diffuse and similar to AD. Ann Neurol 2008
DIN 1052:2004 – Neue Grundlagen für Entwurf, Berechnung und Bemessung von Holzbauwerken – Teil 4 (1): Bemessung von Verbindungen und stiftförmigen und sonstigen mechanischen Verbindungsmitteln
Authors: Lißner Karin , Rug Wolfgang , Steinmetz Dieter 
Published: November 2008

AbstractEs werden Holzbau‐Verbindungsmittel beschrieben und die Regeln für die Bemessung erklärt.
ChemInform Abstract: Electronic Structure of the Iron‐Based Superconductor LaOFeP.
Authors: Lu D. H. , et al. et al. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Intriguing Formal [2 + 3] Cycloaddition Promoted by a hypervalent Iodine Reagent.
Authors: Berard Didier , Giroux Marc‐Andre , Racicot Leanne , Sabot Cyrille , Canesi Sylvain 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Metal Carbene Dimerization: Versatile Approach to Polyalkynylethenes.
Authors: Barluenga Jose , de Saa Diana , Gomez Aranzazu , Ballesteros Alfredo , Santamaria Javier , de Prado Ana , Tomas Miguel , Suarez‐Sobrino Angel L. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Claisen Rearrangements with a Hydrogen‐Bond Donor Catalyst.
Authors: Uyeda Christopher , Jacobsen Eric N. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Construction of Aryliridium—Salen Complexes: Enantio‐ and Cis‐Selective Cyclopropanation of Conjugated and Nonconjugated Olefins.
Authors: Suematsu Hidehiro , Kanchiku Shigefumi , Uchida Tatsuya , Katsuki Tsutomu 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Cyclopentenones via Intramolecular HWE and the Palladium‐Catalyzed Reactions of Allylic Hydroxy Phosphonate Derivatives.
Authors: Yan Bingli , Spilling Christopher D. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Baylis—Hillman Reaction of Cyclic Enones with Arenecarbaldehydes and N‐Arylidene‐4‐methylbenzenesulfonamides by Using NAP‐MgO.
Authors: Kantam M. Lakshmi , Chakrapani L. , Choudary B. M. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Preparation and Processing of the 4‐Methoxybenzyl (PMB) Group for Phenolic Protection Using Ultrasound.
Authors: Luzzio Frederick A. , Chen Juan 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Palladium‐Catalyzed Atom‐Efficient Cross‐Coupling Reactivity of Triarylbismuths with α,β‐Unsaturated Acyl Chlorides.
Authors: Rao Maddali L. N. , Venkatesh Varadhachari , Jadhav Deepak N. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ligand‐Free Sonogashira Coupling Reactions with Heterogeneous Pd/C as the Catalyst.
Authors: Mori Shigeki , Yanase Takayoshi , Aoyagi Satoka , Monguchi Yasunari , Maegawa Tomohiro , Sajiki Hironao 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 5‐(Adamantan‐1‐yl)‐4,4‐dimethyl‐1‐(3‐oxyphenyl)‐2,6,7‐trioxabicyclo [3.2.0]heptanes and Their Base‐Induced Chemiluminescent Decomposition in Liquid/Solid Phase.
Authors: Matsumoto Masakatsu , Tanimura Masatoshi , Tachi Masahiko , Watanabe Nobuko 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Mandelic Acid Derived Phthalimides as a New Class of Antiinflammatory and Antimicrobial Agents.
Authors: Varala Ravi , Kotra Vijay , Alam M. Mujahid , Kumar N. Ramesh , Ganapaty S. , Adapa Srinivas R. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of a 2‐Aminoimidazole Library for Antibiofilm Screening Utilizing the Sonogashira Reaction.
Authors: Richards Justin J. , Melander Christian 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and in vitro Study of Novel Isoxazolyl Benzoimidazolyl Benzamides (V), Acrylamides (VIII) and Propionamides (XI) as Antimicrobial Agents.
Authors: Rajanarendar E. , Ramu K. , Reddy S. Siva Rami , Shaik Firoz Pasha 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Characterization and Pharmacological Studies on Some Triazolothiadiazines and Triazolothiadiazoles Containing Naphtho[2,1‐b]furan.
Authors: Ravindra K. C. , Vagdevi H. M. , Vaidya V. P. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Various Heterocycles Using Coumarinyl Isothiocyanates.
Authors: Mayekar Sagar A. , Mulwad Vinata V. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1,3‐Dipolar Cycloaddition of Difluoro(methylene)cyclopropanes with Nitrones: Efficient Synthesis of 3,3‐Difluorinated Tetrahydropyridinols.
Authors: Hang Xiao‐Chun , Chen Qing‐Yun , Xiao Ji‐Chang 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Aluminum‐Catalyzed Asymmetric Alkylations of Pyridyl‐Substituted Alkynyl Ketones with Dialkylzinc Reagents.
Authors: Friel Donna K. , Snapper Marc L. , Hoveyda Amir H. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cerium(IV) Ammonium Nitrate Catalyzed Facile and Efficient Synthesis of Polyhydroquinoline Derivatives Through Hantzsch Multicomponent Condensation.
Authors: Reddy Cherkupally Sanjeeva , Raghu Mekala 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Indium(III)‐Catalyzed Tandem Reaction with Alkynylbenzaldehydes and Alkynylanilines to Heteroaromatic Compounds.
Authors: Yanada Reiko , Hashimoto Kana , Tokizane Rie , Miwa Yoshihisa , Minami Hideki , Yanada Kazuo , Ishikura Minoru , Takemoto Yoshiji 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cobalt‐Mediated [2 + 2 + 2] Cycloaddition of Alkynyl Boronates to Indole and Pyrrole Double Bonds.
Authors: Amslinger Sabine , Aubert Corinne , Gandon Vincent , Malacria Max , Paredes Elisa , Vollhardt K. Peter C. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Structure and Biological Activities of Some Novel N‐(4,6‐Disubstituted‐pyrimidin‐2‐yl)‐N′‐ (trifluoromethylphenyl)guanidine Derivatives.
Authors: He Feng‐Qi , Liu Xing‐Hai , Wang Bao‐Lei , Li Yong‐Hong , Li Zheng‐Ming 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Synthesis of 6‐Halomethyl‐5,6‐dihydro‐4H‐1,2‐oxazines Based on Cyclizations of Arylalkenyl‐Oximes.
Authors: Karapetyan Vahuni , Mkrtchyan Satenik , Dang Tung T. , Villinger Alexander , Reinke Helmut , Langer Peter 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Novel N‐Substituted 6‐Chlorothieno[2,3‐e]‐1,4,2‐dithiazin‐3‐amine 1,1‐Dioxides.
Authors: Abu‐El‐Halawa Rajab , Al‐Refai Mahmoud H. , El‐Abadelah Mustafa M. , Tabba Hani D. 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Azepines by a Gold‐Catalyzed Intermolecular [4 + 3]‐Annulation.
Authors: Shapiro Nathan D. , Toste F. Dean 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dehydrogenative Cyclocondensation of Aldehydes, Alkynes, and Dialkylsilanes.
Authors: Baxter Ryan D. , Montgomery John 
Published: November 2008

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.