bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhinoplasty Health Inventory and Nasal Outcomes (RHINO) Scale: Translation, Cross-Cultural Adaptation and Validation for Hebrew-Speaking Patients
Authors: Eisenbach Netanel , Mizrachi Matti , Dror Amiel A. , Faris Rania , Ohayon Tali Jane , Ronen Ohad , Sela Eyal 
Published: April 2024

AbstractPatient-reported outcomes questionnaires are accepted measurement tools to evaluate procedures results. The Rhinoplasty Health Inventory and Nasal Outcomes (RHINO) scale is an English-language validated and reliable quality-of-life instrument that evaluates both functional and aesthetic outcomes after rhinoplasty, and is not available in Hebrew. We followed the forward-and-back-translation method, defined by the European Organization for Research and Treatment of Cancer. Translation of the RHINO scale and merging it into one version were performed, following back-translation and validation on native Hebrew-speaking patients who underwent rhinoplasty and control healthy group. Lastly, we review and analyzed the results. The translated questionnaire had high reliability measures, demonstrating homogeneity (α value 0.800 in the rhinoplasty group and 0.896 in the control group), test–retest reproducibility with no significant difference (p = 0.5), and high agreement scores represented by the Bland–Altman plot (95% limits of agreement ranged from 8.78 to 9.80). Validity demonstrated by significant differences between the two study groups' mean questionnaire scores (p < 0.001 for rhinoplasty vs. controls, p < 0.001 for preoperative vs. postoperative, and p = 0.002 for postoperative vs. control group) and also between the aesthetic scores and functional scores of the rhinoplasty group before and after the surgery (p < 0.001). There were no reported understanding problems. The Hebrew version of the RHINO scale is a reliable and valid tool for pre- and post-rhinoplasty surgery outcomes measuring among Hebrew-speaking patients, and can improve coordination of expectations, follow-up, and quantify subjective evaluation of the surgery. Level of evidence: IV.
SFM Fetal Therapy Practice Guidelines: Fetal Cystoscopic Laser Ablation
Authors: Rudrapal Gourisankar , Makkam Adinarayan , Krishnan Vivek 
Published: April 2024

AbstractFetal lower urinary tract obstruction (LUTO) in a male fetus could cause detrimental effects to the KUB (kidney, ureter, and bladder) system from back-pressure changes as well as to the lungs from reduced amniotic fluid. In a carefully selected case where the obstruction causes progressive damage, a therapeutic intervention could be lifesaving. In utero vesico-amniotic shunting has been shown to improve perinatal pulmonary survival, but evidence on improvement of renal outcomes with this procedure is lacking. More recently, fetal cystoscopic laser fulguration has been shown to be beneficial in longer-term survival and renal outcomes. These interventions carry significant risk, and therefore patient selection and optimal timing are key. This guideline lists the intricacies of patient selection, relevant counseling points and procedural details.
Improving Outcome in Severe Myasthenia Gravis and Guillain–Barré Syndrome
Authors: Hawkes Maximiliano A. , Wijdicks Eelco F. M. 
Published: April 2024

AbstractWhen progressive and severe, myasthenia gravis and Guillain–Barré syndrome may have the potential for fatal and unfavorable clinical outcomes. Regardless of important differences in their clinical course, the development of weakness of oropharyngeal muscles and respiratory failure with requirement of mechanical ventilation is the main driver of poor prognosis in both conditions. The need for prolonged mechanical ventilation is particularly relevant because it immobilizes the patient and care becomes extraordinarily complex due to daily risks of systemic complications. Additionally, patients with myasthenia gravis often require long-term immunosuppressive treatments with associated toxicity and infectious risks. Unlike myasthenia gravis, the recovery period is prolonged in Guillain–Barré syndrome, but often favorable, even in the more severely affected patients. Outcome, for a large part, is determined by expert neurocritical care.
An incoherent Thomson scattering system for measurements near plasma boundaries
Authors: Suazo Betancourt Jean Luis , Lopez-Uricoechea Julian , Butler-Craig Naia , Steinberg Adam M. , Walker Mitchell L. R. 
Published: April 2024

Laser Thomson scattering (LTS) is a minimally invasive measurement technique used for determining electron properties in plasma systems. Sheath model closure validation requires minimally invasive measurements of the electron properties that traverse the boundaries between the bulk plasma, the presheath, and the plasma sheath. Several studies have probed the radial properties along the surface of discharge electrodes with laser-based diagnostics and electrostatic probes. These measurements provide valuable insight into the electron properties in this dynamic region. However, sheath model calibration requires plasma property measurements perpendicular to plasma bounding surfaces, in this case, along the electrode normal vector between discharge electrodes. This work presents the development of a discharge plasma cell and laser Thomson scattering system with a measurement volume step of 1 mm normal to plasma bounding surfaces. The laser Thomson scattering measurements are made between a set of discharge electrodes separated by ∼25 mm that are used to generate a pulsed argon plasma. The spatial distribution of electron temperature and density is measured at several discharge voltages between 8 and 20 kV at a pressure of 8 Torr-Ar. It is determined that the system is statistically stationary and resembles a classic DC discharge plasma. The results are some of the first laser diagnostic-based “between electrode” measurements made along the plasma bounding electrode normal vector. A one-dimensional sheath model is applied to determine the near cathode electron properties, and it is determined that the edge of the presheath is probed in the high-voltage cases. As the lengths of the presheath and sheath decrease with decreasing voltage, the region recedes below the closest probed point to the cathode. To improve the performance of the diagnostic, the step size of the interrogation volume should decrease by an order of magnitude from 1 mm to less than 100 μm, and the data acquisition strategy should be revised to increase the signal-to-noise ratio.
Crystallographic and band structure analysis of β-(AlxGa1−x)2O3/β-(InyGa1−y)2O3 thin film grown on β-Ga2O3 substrate via mist CVD
Authors: Kaneko Masahiro , Nishinaka Hiroyuki , Yoshimoto Masahiro 
Published: April 2024

We successfully achieved the growth of a stacked layer composed of β-(AlxGa1−x)2O3/β-(InyGa1−y)2O3 on a (010) β-Ga2O3 substrate using mist chemical vapor deposition (CVD). X-ray diffraction and reciprocal space mapping analyses were conducted, elucidating that the multilayer structure of the β-(AlxGa1−x)2O3/β-(InyGa1−y)2O3 thin film exhibited excellent crystallinity and coherent growth. Scanning transmission electron microscopy further revealed a continuous atomic arrangement at the heterointerface of β-(AlxGa1−x)2O3/β-(InyGa1−y)2O3. Furthermore, the bandgap values of β-(AlxGa1−x)2O3 and β-(InyGa1−y)2O3 thin films were determined to be 5.21 and 4.62 eV, respectively, through electron energy-loss spectroscopy. Notably, a slight broadening was observed in the bandgap transition at the interface of β-(AlxGa1−x)2O3/β-(InyGa1−y)2O3. Energy dispersive x-ray spectroscopy analysis indicated that this phenomenon could be attributed to the diffusion of In into the β-(AlxGa1−x)2O3 thin film layer. These results support mist CVD as a promising growth technique for developing β-Ga2O3-based heterojunction devices.
Non-toxic orange carbon dots stimulate photosynthesis and CO2 assimilation in hydroponically cultivated green beans (Phaseolus vulgaris)
Authors: Milenković Ivana , Borišev Milan , Zhou Yiqun , Spasić Sladjana Z. , Spasić Dunja , Leblanc Roger M. , Radotić Ksenija 
Published: April 2024

Continuous increasing leaf photosynthesis may enhance plant yield. As an evolutionary property, plants use less photosynthetic capacity than is theoretically possible. Plant nanobionics is a bioengineering field that improves plant functions using nanoparticles. We applied orange carbon dots (o-CDs) onto the foliage of green beans (Phaseolus vulgaris) grown in hydroponics to improve their photosynthetic performance and CO2 assimilation. Photosynthesis parameters, photosynthetic pigments content, total phenolic content (TPC) and antioxidative activity (TAA) were measured. Results show that photosynthetic pigments remained unchanged, while photosynthesis was improved. Both o-CDs concentrations decreased TPC and TAA. The light response curve showed higher CO2 assimilation at both o-CDs concentrations, particularly at lower light intensity. Correlation analysis confirmed increased CO2 binding and assimilation at 1 mg L−1. This study demonstrated the potential of using o-CDs as a safe biostimulator through photosynthesis increase and CO2 assimilation without toxic effects on plants. This may stimulate yield increase that paves the way for their agricultural application.
Determination of the resonant parameters of
with global fit*
Authors: Li 李 Chunhua 春花 , Wang 王 Xijun 希俊 , Wu 吴 Chen 晨 
Published: April 2024

Abstract
Particle

was first observed by the Belle experiment in the

invariant mass spectrum in the process

and subsequently confirmed by the BaBar experiment. Both experiments reported the resonant parameters of this particle in the processes

and

assuming

as an S-wave Breit-Wigner resonance. We performed a global fit to the distributions of invariant mass of

measured by the Belle and BaBar experiments and additionally incorporated the measurements reported by the LHCb experiment to extract the mass and width of

. We obtained

MeV/

and

MeV, which are consistent with the values from PDG within one standard deviation but with higher precision.
Power to the people: why person-generated health data are important for pharmacoepidemiology
Authors: Dreyer Nancy A , Blackburn Stella C F 
Published: March 2024

Abstract
Person-generated health data (PGHD) are valuable for studying outcomes relevant to everyday living, for obtaining information not otherwise available, for long-term follow-up, and in situations where decisions cannot wait for traditional clinical research to be completed. While there is no dispute that these data are subject to bias, insights gained may be better than having an information void, provided the biases are understood and addressed. People will share information known uniquely to them about exposures that may affect drug tolerance, safety, and effectiveness (eg, nonprescription and complementary medications, alcohol, tobacco, illicit drugs, exercise, etc). Patients may be the best source of safety information when long-term follow-up is needed (eg, the 5- to 15-year follow-up required for some gene therapies). Validation studies must be performed to evaluate what people can accurately report and when supplementary confirmation information is needed. However, PGHD has already proven valuable in quantifying and contrasting COVID-19 vaccine benefits and risks and for evaluating disease transmission and the accuracy of COVID-19 testing. Going forward, PGHD will be used for patient-measured and patient-relevant outcomes, including for regulatory purposes, and will be linked to broader health data networks using tokenization, becoming a mainstay for signals about risks and benefits for diverse populations.
This article is part of a Special Collection on Pharmacoepidemiology.
Plant kleptomaniacs: geographical genetic patterns in the amphi-apomictic Rubus ser. Glandulosi (Rosaceae) reveal complex reticulate evolution of Eurasian brambles
Authors: Sochor Michal , Šarhanová Petra , Duchoslav Martin , Konečná Michaela , Hroneš Michal , Trávníček Bohumil 
Published: March 2024

Abstract

Background and Aims
Rubus ser. Glandulosi provides a unique model of geographical parthenogenesis on a homoploid (2n = 4x) level. We aim to characterize evolutionary and phylogeographical patterns in this taxon and shed light on the geographical differentiation of apomicts and sexuals. Ultimately, we aim to evaluate the importance of phylogeography in the formation of geographical parthenogenesis.

Methods
Rubus ser. Glandulosi was sampled across its Eurasian range together with other co-occurring Rubus taxa (587 individuals in total). Double-digest restriction site-associated DNA sequencing (ddRADseq) and modelling of suitable climate were used for evolutionary inferences.

Key Results
Six ancestral species were identified that contributed to the contemporary gene pool of R. ser. Glandulosi. Sexuals were introgressed from Rubus dolichocarpus and Rubus moschus in West Asia and from Rubus ulmifolius agg., Rubus canescens and Rubus incanescens in Europe, whereas apomicts were characterized by alleles of Rubus subsect. Rubus. Gene flow between sexuals and apomicts was also detected, as was occasional hybridization with other taxa.

Conclusions
We hypothesize that sexuals survived the last glacial period in several large southern refugia, whereas apomicts were mostly restricted to southern France, whence they quickly recolonized Central and Western Europe. The secondary contact of sexuals and apomicts was probably the principal factor that established geographical parthenogenesis in R. ser. Glandulosi. Sexual populations are not impoverished in genetic diversity along their borderline with apomicts, and maladaptive population genetic processes probably did not shape the geographical patterns.
Managing the Risk of Living: Life Imprisonment, the Medical Gaze and the Construction of the Paroled Body
Authors: Dagan Netanel , Vannier Marion 
Published: March 2024

Abstract
Drawing on Israeli life-sentence parole hearings, we argue that release decisions are centred on the body, not the soul. The board employs a ‘medical gaze’ that dissects the paroled body by magnifying the applicant’s dying body and narrowing the gaze to evaluate the days left to live. A new risk emerges: the risk of living upon release rather than dying. The board is ambivalent when managing this risk: the body is treated with suspicion, the applicant is criticized for their bodily state and risk and populist discourses are recalled to back parole decisions. Contrary to the conventional wisdom that portrays parole as focussing on rehabilitation and risk, the construction of the paroled body to manage the risk of living amounts to denying any moral worth or possibility of personal growth.
CacyBP promotes the development of lung adenocarcinoma by regulating OTUD5
Authors: Bai Mixue , Lu Kun , Che Yingying , Fu Lin 
Published: April 2024

Abstract
Lung cancer is the most common and lethal malignancy, with lung adenocarcinoma accounting for approximately 40% of all cases. Despite some progress in understanding the pathogenesis of this disease and developing new therapeutic approaches, the current treatments for lung adenocarcinoma remain ineffective due to factors such as high tumour heterogeneity and drug resistance. Therefore, there is an urgent need to identify novel therapeutic targets. Calcyclin-binding protein (CacyBP) can regulate a variety of physiological processes by binding to different proteins, but its function in lung adenocarcinoma is unknown. Here, we show that CacyBP is highly expressed in lung adenocarcinoma tissues, and high CacyBP expression correlates with poorer patient survival. Moreover, overexpression of CacyBP promoted the proliferation, migration and invasion of lung adenocarcinoma cell lines. Further mechanistic studies revealed that CacyBP interacts with the tumour suppressor ovarian tumour (OTU) deubiquitinase 5 (OTUD5), enhances the ubiquitination and proteasomal degradation of OTUD5 and regulates tumourigenesis via OTUD5. In conclusion, our study reveals a novel mechanism by which CacyBP promotes tumourigenesis by increasing the ubiquitination level and proteasome-dependent degradation of OTUD5, providing a potential target for the treatment of lung adenocarcinoma.
Photophysical properties of 1-Aza-2-boraacenaphthene synthesized by a reduction of base-stabilized aminodibromoborane
Authors: Kumada Haruki , Nakano Ryo , Yamashita Makoto 
Published: March 2024

Abstract
Among heteroaromatics, the chemistry of boron/nitrogen-incorporated (BN)-heteroaromatic compounds is relatively old, but it is not well explored. Here, we report the synthesized new member of BN-heteroaromatics, 1-aza-2-boraacenaphthene 4. Structural characterization of 4 by using x-ray crystallography indicated the strong interaction between B and O atoms through the pπ-pπ interaction. Formation of 4 can be explained by involving a radical intermediate according to our previous report. The absorption and emission properties of 4 were compared with reference compounds to reveal the character of oxygen-substituted 1-aza-2-boraacenaphthene. Density functional theory calculations also support the similarity between 4 and the parent compound.
Synthesis of O–N–S self-doped carbon quantum dots from a discarded football for Fe3+ detection
Authors: Shi Jiangnian 
Published: April 2024

Abstract
A discarded-waste football was served as a carbon precursor to build O–N–S self-doped carbon quantum dots (CQDs) by a hydrothermal route. The CQDs have strong cyan luminescence, excellent stability, and their excitation is wavelength-dependent. The CQDs were acted as a fluorescent probe for the detection of Fe3+, exhibiting sensitivity and selectivity, which is of great significance for the effective monitoring of human health.
Enhancing cardiac pacing strategies: a review of conduction system pacing compared with right and biventricular pacing and their influence on myocardial function
Authors: Mirmaksudov Mirakhmadjon , Ross Stian , Kongsgård Erik , Edvardsen Thor 
Published: April 2024

Abstract
Traditional right ventricular pacing (RVP) has been linked to the deterioration of both left ventricular diastolic and systolic function. This worsening often culminates in elevated rates of hospitalization due to heart failure, an increased risk of atrial fibrillation, and increased morbidity. While biventricular pacing (BVP) has demonstrated clinical and echocardiographic improvements in patients afflicted with heart failure and left bundle branch block, it has also encountered significant challenges such as a notable portion of non-responders and procedural failures attributed to anatomical complexities. In recent times, the interest has shifted towards conduction system pacing, initially, His bundle pacing, and more recently, left bundle branch area pacing, which are seen as promising alternatives to established methods. In contrast to other approaches, conduction system pacing offers the advantage of fostering more physiological and harmonized ventricular activation by directly stimulating the His–Purkinje network. This direct pacing results in a more synchronized systolic and diastolic function of the left ventricle compared with RVP and BVP. Of particular note is the capacity of conduction system pacing to yield a shorter QRS, conserve left ventricular ejection fraction, and reduce rates of mitral and tricuspid regurgitation when compared with RVP. The efficacy of conduction system pacing has also been found to have better clinical and echocardiographic improvement than BVP in patients requiring cardiac resynchronization. This review will delve into myocardial function in conduction system pacing compared with that in RVP and BVP.
The impact of natural constraints in linear regression of log transformed response variables
Authors: Fortin Mathieu 
Published: April 2024

AbstractIn linear regression, log transforming the response variable is the usual workaround regarding departures from the assumption of normality. However, the response variable is often subject to natural constraints, which can result in a truncated distribution of the residual errors on the log scale. In forestry, allometric relationships and tree growth are two typical examples a natural constraint; the response variable cannot be negative. Traditional least squares estimators do not account for constrained response variables. For this study, a modified maximum likelihood (MML) estimator that takes natural constraints into account was developed. This estimator was tested through a simulation study and showcased with black spruce tree diameter increment data. Results show that the ordinary least squares estimator underestimated large conditional expectations of the response variable on the original scale. In contrast, the MML estimator showed no evidence of bias for large sample sizes. Departures from distributional assumptions cannot be overlooked when the model is used for predictive purposes. Both Monte Carlo error propagation and prediction intervals rely on these assumptions. In this context, the MML estimator developed for this study can be used to properly propagate the errors and produce reliable prediction intervals.
Modulators of MAPK pathway activity during filamentous growth in Saccharomyces cerevisiae
Authors: Pujari Atindra N , Cullen Paul J 
Published: April 2024

Abstract
Mitogen-activated protein kinase (MAPK) pathways control the response to intrinsic and extrinsic stimuli. In the budding yeast Saccharomyces cerevisiae, cells undergo filamentous growth, which is regulated by the fMAPK pathway. To better understand the regulation of the fMAPK pathway, a genetic screen was performed to identify spontaneous mutants with elevated activity of an fMAPK pathway–dependent growth reporter (ste4 FUS1-HIS3). In total, 159 mutants were isolated and analyzed by secondary screens for invasive growth by the plate-washing assay and filament formation by microscopy. Thirty-two mutants were selected for whole-genome sequencing, which identified new alleles in genes encoding known regulators of the fMAPK pathway. These included gain-of-function alleles in STE11, which encodes the MAPKKK, as well as loss-of-function alleles in KSS1, which encodes the MAP kinase, and loss-of-function alleles in RGA1, which encodes a GTPase-activating protein (GAP) for CDC42. New alleles in previously identified pathway modulators were also uncovered in ALY1, AIM44, RCK2, IRA2, REG1, and in genes that regulate protein folding (KAR2), glycosylation (MNN4), and turnover (BLM10). Mutations leading to C-terminal truncations in the transcription factor Ste12p were also uncovered that resulted in elevated reporter activity, identifying an inhibitory domain of the protein from residues 491 to 688. We also find that a diversity of filamentous growth phenotypes can result from combinatorial effects of multiple mutations and by loss of different regulators of the response. The alleles identified here expand the connections surrounding MAPK pathway regulation and reveal new features of proteins that function in the signaling cascade.