bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sulfonate derivatives bearing an amide unit: design, synthesis and biological activity studies
Authors: Liu You-hua , Li Chang-kun , Nie Mao-yu , Wang Fa-li , Ren Xiao-li , Jin Lin-hong , Zhou Xia 
Published: March 2024

AbstractPest disasters which occurs on crops is a serious problem that not only cause crop yield loss or even crop failure but can also spread a number of plant diseases.Sulfonate derivatives have been widely used in insecticide and fungicide research in recent years. On this basis, a series of sulfonate derivatives bearing an amide unit are synthesized and the biological activities are evaluated. The bioassay results showed that compounds A8, A13, A16, B1, B3, B4, B5, B10, B12 − 20, C3, C5, C9, C10, C14, C15, C17 and C19 showed 100% activity at a concentration of 500 µg/mL against the Plutella xylostella (P. xylostella). Among them, B15 which contains a thiadiazole sulfonate structure still shows 100% activity at 50 µg/mL concentration against P. xylostella and had the lowest median lethal concentration (LC50) (7.61 µg/mL) among the target compounds. Further mechanism studies are conducted on compounds with better insecticidal activity. Molecular docking results shows that B15 formed hydrophobic interactions π-π and hydrogen bonds with the indole ring of Trp532 and the carboxyl group of Asp384, respectively, with similar interaction distances or bond lengths as those of diflubenzuron. Moreover, chitinase inhibition assays are performed to further demonstrate its mode of action. In addition, the anti-bacterial activity of the series of compounds is also tested and the results showed that the series of compounds has moderate biological activity against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas oryzae pv. oryzicola (Xoc), with inhibition rates of 91%, 92% and 92%, 88% at the concentration of 100 µg/mL, respectively. Our study indicates that B15 can be used as a novel insecticide for crop protection.
Graphical Abstract
Efficiency of fluralaner pour-on in different strategic control protocols against Rhipicephalus microplus on Brangus cattle in a tropical area
Authors: Reckziegel Guilherme Henrique , de Freitas Mariana Green , Tutija Juliane Francielle , Rodrigues Vinícius Duarte , Borges Dyego Gonçalves Lino , de Freitas Murilo Damasceno Brunet , Gallina Tiago , Lopes Welber Daniel Zanetti , de Castro Rodrigues Daniel , de Oliveira Arriero Amaral Heitor , Strydom Tom , Torres Siddhartha , de Almeida Borges Fernando 
Published: March 2024

Abstract
Background
The occurrence of higher winter temperatures in Brazilian areas with tropical and highland climates may result in a fifth peak of tick populations during winter in addition to the four generations previously described. Therefore, a strategic control protocol was developed with treatments in two seasons with the objective of controlling the generations of ticks that occur in spring/summer and those that occur in autumn/winter.

Methods
The study was conducted in Mato Grosso do Sul, Brazil, from the beginning of the rainy season, November 2020, to October 2021. In a randomized block design, 36 calves were distributed into three groups: (i) negative control; (ii) traditional strategic control in one season (SC1S), at the beginning of the rainy season; and (iii) strategic control in two seasons (SC2S), at the beginning and end of the rainy season. The SC1S strategic control group was treated on day 0, November 2020, and twice more with intervals of 42 days. The SC2S group received three more treatments beginning on day 182, May 2021, with intervals of 42 days. All treatments consisted of 5% fluralaner (Exzolt® 5%) delivered via a pour-on dose of 1 mL/20 kg body weight. Counts of semi-engorged female ticks were performed on day 3 and every 14 days thereafter, and the animals were weighed at the same time.

Results
Fluralaner showed a mean efficacy of more than 95% up to day 294. The two treated groups showed a decrease (P < 0.05) in the average number of ticks on day 3. In the SC2S group, the means were close or equal to zero throughout the study, while in the SC1S group, the means did not differ (P > 0.05) from those of the control group from day 231 onward. The final mean weight gain of each group was 76.40 kg, 98.63 kg, and 115.38 kg for the control, SC1S, and SC2S groups, respectively, differing (P < 0.05) from each other.

Conclusions
Therefore, three applications of fluralaner, with one application every 42 days from the beginning of the rainy season in the middle spring, resulted in effective tick control for 224 days. When three additional treatments were given in autumn/winter with intervals of 42 days between applications, tick counts were reduced throughout the year. This strategic control approach may be indicated in years with climatic conditions that allow that population peaks are expected to occur in the autumn/winter period.

Graphical Abstract
A new medical device applied in a case of acute fecal impaction with overflow diarrhea: a case report
Authors: Huang Qin , Zheng Fan , Wang Hongxia , Yang Yong , Ma Chun , Zhu Likun 
Published: March 2024

Abstract
Background
Fecal impaction is a digestive system disease, that is most common in the elderly population and becomes more prevalent with increasing age. Manual removal can successfully remove the impaction in 80% of fecal impaction cases. In severe cases, endoscopy and surgery may be necessary.

Case presentation
A 78-year-old Han Chinese man living in a nursing home was diagnosed with fecal impaction; his initial symptom was overflow diarrhea, which is a rare occurrence with regard to fecal impaction. Nevertheless, we were able to effectively treat this situation by employing a new medical device that presents a novel method for addressing fecal impaction.

Conclusion
Early identification of fecal impaction with atypical symptoms is crucial to provide proper emergency management. A safe and noninvasive treatment method, especially for elderly patients with fecal impaction, should be chosen.
Relationship between fear of evaluation, ambivalence over emotional expression, and self-compassion among university students
Authors: Huang Tian , Wang Wenbo 
Published: March 2024

Abstract
Background
This study focuses on college students as research subjects, exploring the relationship between fear of evaluation, ambivalence over emotional expression, and self-care, as well as the moderating effect of self-care on the prediction of ambivalence over emotional expression by fear of evaluation.

Methods
This study selected physical education college students in Sichuan Province as the research participants. Convenience sampling was used to recruit participants through public recruitment information and questionnaire links on online platforms commonly used by college students. The questionnaire was distributed at two different time points to reduce the effect of common method bias. A total of 858 questionnaires were distributed, after excluding duplicate responses, a total of 743 valid questionnaires were obtained.

Results
The result as following: (1) College students exhibit a moderate to high level of negative fear of evaluation, ambivalence over emotional expression, and self-care, with female students having higher negative fear of evaluation; (2) There are significant correlations between fear of evaluation, ambivalence over emotional expression, and self-care; (3) Fear of evaluation and self-care can predict ambivalence over emotional expression, but self-care does not have a moderating effect on the prediction of ambivalence over emotional expression by fear of evaluation; (4) Self-care and negative self-care both have a moderating effect on the prediction of emotion rumination by positive fear of evaluation.

Conclusions
In the past, rumination has often been considered a manifestation of excessive rumination and anxiety. However, this study found that self-compassion’s modulation on fear of positive evaluation intensifies its impact on emotional rumination. Research suggests that moderate emotional rumination may not necessarily be a negative outcome and reflects a positive emotional adjustment process to some extent. Therefore, future studies can further explore the growth and decline of internal rumination processes in self-compassion or counseling, and potentially gain a better understanding of key elements of personal growth.
The impact of parenting practices and family economy on psychological wellbeing and learning patterns in higher education students
Authors: Gandarillas M. A. , Elvira-Zorzo M. N. , Rodríguez-Vera M. 
Published: March 2024

Abstract
Background
There is a large literature on the significant impact of rearing factors in the psychological development of different child’s learning patterns and wellbeing in elementary and secondary schools, but there is a scarcity of studies on to what extent those influences remain stable up to higher education.

Objective
In this study, parenting practices and family status were analyzed as predictors of the different learning styles, psychological difficulties, mental health factors, and academic performance, comprising the psychosocial diversity in learning (DinL) at the university classroom.

Methods
Using a cross-sectional design, a questionnaire was administered to a sample of 2522 students at the Complutense University of Madrid (Spain). It included a DinL scale measuring five psychological learning dimensions (coping with difficulties, effort, autonomy, Social/Physical Context, and understanding/career interest), plus several items on retrospective parenting practices, family, and sociodemographic variables. Multiple regressions and analyses of variance were conducted with the family factors as independent variables and the learning factors as dependent variables.

Results
Results showed parenting variables, parents’ education, and family economy as having a significant impact on psychological learning dimensions, academic performance, and especially on the students’ wellbeing and mental health status, being an important contributors to explain the DinL in the university classroom.

Conclusion
The results bring interesting conclusions for developmental and health psychologists when working with parents aimed at fostering wellbeing and learning strategies related to academic inclusion and achievement.
Harnessing metamaterials for efficient wireless power transfer for implantable medical devices
Authors: Mahmud Sultan , Nezaratizadeh Ali , Satriya Alfredo Bayu , Yoon Yong-Kyu , Ho John S. , Khalifa Adam 
Published: March 2024

AbstractWireless power transfer (WPT) within the human body can enable long-lasting medical devices but poses notable challenges, including absorption by biological tissues and weak coupling between the transmitter (Tx) and receiver (Rx). In pursuit of more robust and efficient wireless power, various innovative strategies have emerged to optimize power transfer efficiency (PTE). One such groundbreaking approach stems from the incorporation of metamaterials, which have shown the potential to enhance the capabilities of conventional WPT systems. In this review, we delve into recent studies focusing on WPT systems that leverage metamaterials to achieve increased efficiency for implantable medical devices (IMDs) in the electromagnetic paradigm. Alongside a comparative analysis, we also outline current challenges and envision potential avenues for future advancements.
Current knowledge and practice of post-stroke unilateral spatial neglect rehabilitation: a national survey of Nigerian physiotherapists
Authors: Umeonwuka Chuka Ifeanyi , Roos Ronel , Ntsiea Veronica 
Published: March 2024

Abstract
Background
Unilateral spatial neglect (USN) is a leading cause of disability and handicap in stroke survivors affecting functional recovery. Therapists’ knowledge and practice in post-stroke unilateral spatial neglect are key to the success of rehabilitation.

Aim
This study aimed to evaluate physiotherapists’ knowledge of USN and the current practice of USN management.

Method
A cross-sectional study was undertaken among Nigerian physiotherapists (N = 240). An online structured questionnaire that assessed respondents’ knowledge, current practice, barriers, and enablers to post-stroke USN rehabilitation was administered.

Results
The total knowledge score was 12.6 ± 4.75 on a scale of 25. Few physiotherapists (7.92%) demonstrated good knowledge of USN. Postgraduate certification (p = 0.001), clinical practice setting (p = 0.008), and working full time in neurorehabilitation (p = 0.033) were significantly associated with the therapist’s knowledge of USN. There was a nonsignificant positive correlation between the duration of practice in the neurorehabilitation setting (r = 0.02; p = 0.854) and USN knowledge. A nonsignificant minimal negative correlation between practice as a physiotherapist (r =  − 0.02; p = 0.772) and USN knowledge was also noted. The age of physiotherapists showed no linear relationship with the therapist’s knowledge of USN (r =  − 0.00; p = 0.992). Constraint-induced movement therapy (86.47%) was the most commonly used USN treatment, while Albert’s test (49.37%) was the most utilized screening tool for USN.

Conclusions
Very few physiotherapists had good knowledge of USN. Participants’ knowledge increased as they attained higher education levels relating to neurological physiotherapy. These findings emphasize the need for specialist rehabilitation training for physiotherapy practice.
Olaparib in Patients With Pancreatic Cancer With BRCA1/2 Mutations: Results From the Targeted Agent and Profiling Utilization Registry Study
Authors: Ahn Eugene R. , Rothe Michael , Mangat Pam K. , Garrett-Mayer Elizabeth , Calfa Carmen J. , Alva Ajjai S. , Suhag Vijay , Alese Olatunji B. , Dotan Efrat , Hamid Omid , Yang Eddy S. , Marr Alissa S. , Palmer Martin C. , Thompson Forrest L. , Yost Kathleen J. , Gregory Abigail , Grantham Gina N. , Hinshaw Dominique C. , Halabi Susan , Schilsky Richard L. 
Published: March 2024

PURPOSE Targeted Agent and Profiling Utilization Registry (TAPUR) is a phase II basket trial evaluating the antitumor activity of commercially available targeted agents in patients with advanced cancer and genomic alterations known to be drug targets. Results of a cohort of patients with advanced pancreatic cancer with BRCA1/ 2 mutations treated with olaparib are reported. METHODS Eligible patients had advanced pancreatic cancer, measurable disease, Eastern Cooperative Oncology Group performance status 0-2, adequate organ function, and no standard treatment options available. Genomic testing was performed in Clinical Laboratory Improvement Amendments–certified, College of American Pathologists-accredited site selected laboratories. Simon's two-stage design was used with a primary end point of disease control (DC), defined as objective response (OR) or stable disease of at least 16 weeks duration (SD16+) according to RECIST v1.1. Secondary end points included OR, progression-free survival (PFS), overall survival (OS), duration of response, duration of stable disease, and safety. RESULTS Thirty patients with BRCA1/ 2 mutations were enrolled from November 2016 to August 2019. The median number of reported previous therapies was 3 (range, 1-10). Two patients were not evaluable and excluded from efficacy analyses. Two patients with complete response, three with partial response and three with SD16+, were observed for DC and OR rates of 31% (90% CI, 18 to 40; P = .04) and 18% (95% CI, 6 to 37), respectively. The median PFS was 8 (95% CI, 8 to 15) weeks, and the median OS was 38 (95% CI, 21 to 65) weeks. Three patients had at least one drug-related grade 3 adverse event or serious adverse event of anemia, fever, or oral mucositis. CONCLUSION Olaparib showed antitumor activity in patients with advanced pancreatic cancer with BRCA1/ 2 mutations extending findings of recent studies of olaparib in patients with this disease.
Weight Loss Outcomes in a Veterans Affairs Pharmacotherapy-based Weight Management Clinic
Authors: Ni Kevin , Rogowitz Elisa , Farahmand Abtin K , Kaizer Laura K , Arbet Jaron , Cunningham Christina R , Thomas Elizabeth A , Saxon David R 
Published: March 2024

Abstract

Context
Despite a high prevalence of obesity in the veteran population, antiobesity medications (AOMs) have been underused in the Veterans Health Administration. Real-world reports on outcomes when AOMs have been used in veterans is limited.

Objective
To analyze weight loss outcomes from a local Veterans Health Administration pharmacotherapy-based weight management clinic (WMC).

Methods
This was a retrospective cohort study of veterans enrolled in a local WMC for 15 months from August 2016 through September 2018 and followed through November 2019. Patients were offered 1 of 5 available AOMs based on their comorbidities. Factors associated with weight loss (5% or more weight loss) were assessed.

Key results
A total of 159 patients were seen in a WMC, 149 (93.7%) veterans were prescribed an AOM, and 129 returned for follow-up. Overall, 61/129 (47%) patients achieved 5% or greater weight loss and 28/129 (22%) achieved 10% or greater weight loss within 15 months. Clinically significant weight loss (%) over the first 15 months was achieved with phentermine/topiramate ER (−6.3%) and liraglutide (−7.5%), but not with orlistat (−3.9%) and lorcaserin (−3.6%). Comorbid obstructive sleep apnea was negatively associated with achieving ≥5% weight loss.

Conclusion
Phentermine/topiramate ER and liraglutide were found to be effective AOMs among veterans. Further work is needed to mitigate barriers to AOM initiation given the continued rise in obesity.
Due biblioteche cracoviesi del tardo Seicento: piani di lettura incrociati fra presente e passato
Authors: Mazzei Rita 
Published: March 2024

Il saggio prende in esame due biblioteche tardo-seicentesche, di cittadini cracoviesi di origine italiana. Quella di Andrzej Kortyn, ossia Andrea Cortini, italiano di seconda generazione, con poco più di una settantina di titoli; e quella del mercante lucchese Girolamo Pinocci, con poco meno di duemila titoli. La formazione di entrambe risaliva al secolo precedente, e i dati incrociati dell’una e dell’altra ci parlano della Cracovia seicentesca, ma anche di quella che era stata l’antica capitale del Regno, e dei suoi molteplici legami con l’Italia.

Artykuł omawia dwie biblioteki z drugiej połowy XVII w., będące własnością mieszczan krakowskich pochodzenia włoskiego. Pierwsza z nich, należąca do Andrzeja Kortyna vel Andrei Cortiniego, włoskiego migranta drugiego pokolenia, liczyła nieco ponad 70 tytułów, a druga, której właścicielem był kupiec z Lukki Girolamo Pinocci – nieco mniej niż 2 tys. tytułów. Obydwie powstały w poprzednim stuleciu, a zbiorcza analiza wypływających z nich informacji pozwala na poznanie nie tylko siedemnastowiecznego Krakowa, ale również dawniejszego miasta, niegdyś stolicy Królestwa, oraz jego wielorakich związków z Italią.
Exploring health professionals' knowledge of cancer-related pain: a scoping review
Authors: Galligan Martin , Verity Rebecca , Briggs Emma 
Published: March 2024

Background: Cancer-related pain is a complex multidimensional experience that affects all aspects of life. To support those impacted by cancer-related pain it is essential that health professionals have adequate knowledge in its assessment and management. Aims: To explore the knowledge of health professionals regarding cancer-related pain. Methods: A scoping review methodology was used to systematically search the literature published between 2010 and 2020. Databases CINAHL, Medline and PsycINFO were searched using terms ‘cancer pain’, ‘healthcare professional’, ‘knowledge’, ‘attitudes’ and ‘barriers’. Findings: The search identified 38 articles. They focused on nursing knowledge with minimal involvement of allied health professionals. Knowledge levels were variable with the majority demonstrating poor knowledge. Common knowledge gaps included around fear of addiction, principles of cancer-related pain assessment and management, and interventional techniques. Conclusion: Knowledge of cancer-related pain is variable with several knowledge gaps. More work is needed to ensure health professionals have adequate knowledge regarding the complexity of cancer-related pain.
Assessment of complementary health approaches use in pediatric oncology: Modification and preliminary validation of the "Which Health Approaches and Treatments Are You Using?" (WHAT) questionnaires
Authors: Alqudimat Mohammad R. , Toupin April Karine , Jibb Lindsay , Victor Charles , Nathan Paul C. , Stinson Jennifer 
Published: March 2024

Objective
Complementary Health Approaches (CHA) are commonly used by children with cancer; however, a few health care providers (HCPs) inquire about the use of CHA. A standardized questionnaire could facilitate such clinical discussions. We aimed to adapt and determine the face and content validity of the “Which Health Approaches and Treatments are you using?" (WHAT) child and parent-report questionnaires in pediatric oncology.

Methods
An electronic Delphi survey that included children with cancer (8–18 years), parents, and HCPs and CHA researchers was conducted to reach consensus on the content of the WHAT questionnaires in pediatric oncology. Children and parents from the Hospital for Sick Children (SickKids), and HCPs and researchers from the International Society of Pediatric Oncology and Pediatric Complementary and Alternative Medicine Research and Education Network completed the survey. To determine the face and content validity of the questionnaires, two iterative cycles of individual interviews were conducted with purposive samples of children (8–18 years), parents, and HCPs from SickKids.

Results
Consensus was reached on all domains and items of the original WHAT questionnaires after one Delphi cycle (n = 61). For face and content validity testing, the first cycle of interviews (n = 19) revealed that the questionnaires were mostly comprehensive and relevant. However, the paper-based format of the original WHAT was not user-friendly, and generic items were vague and not aimed at facilitating clinical dialogues about CHA use. The WHAT questionnaires were then modified into electronic cancer-specific self- and proxy-report questionnaires including 13 and 15 items, respectively. The second cycle (n = 21) showed no need for further changes.

Conclusions
The modified electronic cancer-specific WHAT questionnaires showed adequate face and content validity. The next step is to determine inter-rater reliability, construct validity, and feasibility of administration of the modified WHAT questionnaires in pediatric oncology.