bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incorporation of dendritic silica nanoparticles for the preparation of high‐performance thin‐film nanocomposite membranes
Authors: Huang Huawei , Hu Yiwen , Song Xiuduo , Kang Jian , Chen Dandan 
Published: April 2024

AbstractThe development of thin‐film nanocomposite (TFN) membranes with high performance is conducive to efficient desalination and wastewater treatment. In this work, dendritic mesoporous silica nanoparticles (DLSiO2) were synthesized by a dual‐templating strategy. Afterward, they were introduced into the aqueous phase to fabricate TFN membranes via in situ interfacial polymerization (IP) reaction. Powerful techniques as scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, Nano zetasizer‐DLS, x‐ray photoelectron microscopy, electrokinetic analyzer, and contact angle were used in the characterization of dendritic structures and nanocomposite membranes. Results revealed that DLSiO2 with special structural characteristics can effectively regulate the IP process, promoting the enhancement of the crosslinking degree, surface hydrophilicity, and surface negative charge of polyaimde (PA) selective layers. It is also beneficial for constructing extra water channels within the PA selective layer to boost the transport of water molecules. As a consequence, the prepared TFN membrane with 0.3 mg/mL DLSiO2 exhibits optimal separation performance and good pressure resistance, acid–base resistance, and anti‐fouling properties. It also exhibited a water permeability of 4.17 L m−2 h−1 bar−1 (increased by 61.7% compared with thin film composites (TFC) membrane) and a NaCl rejection of 99.0%, which were better than those of TFN membranes prepared by introducing other types of silica in other studies.
pH‐Responsive Calcium Ions and Crocetin Releasing Hydrogel for Accelerating Skin Wound Healing
Authors: Wang Li , Ma Xuemei , Pan Yanan , Ye Haoxiang , Liu Zike , Kuang Zaoyuan , Zhao Zhongxiang , Liu Aijun , Ji Yuxing 
Published: April 2024

AbstractThe ideal and highly anticipated dressing for skin wounds should provide a moist environment, possess antibacterial properties, and ensure sustained drug release. In the present work, a hyaluronic acid‐based hydrogel was formed by cross‐linking crocetin and CaCO3@polyelectrolyte materials (CaCO3@PEM) microspheres with HA hydrogels via hydrogen bond and amido bonding (CaCO3@PEM@Cro@HA hydrogel, CPC@HA hydrogel). Moreover, the CPC@HA hydrogel had the capability of sustained, controlled release of calcium ions and crocetin via pH‐sensitive and accelerated skin wound healing. The experiment results showed that the CPC@HA hydrogel exhibited porous network structures, stable physical properties, and had antibacterial properties and biocompatibility in vitro. In addition, the CPC@HA hydrogel covering on the skin wound could reduce inflammation and promote wound healing. The high expression of angiogenic cytokines (CD31) and epidermal terminal differentiation markers (Loricrin) of wound healing tissue suggested the CPC@HA hydrogel also had the function of promoting the remodeling of regenerated skin. Overall, CPC@HA hydrogel has promising potential for clinical applications in accelerating skin wound repair.
Microflow, Sequential Coupling and Cyclization Approach for Synthesis of Cyclic Phosphotriesters from PCl3
Authors: Nakabayashi Kohei , Kitamura Hiroshi , Fuse Shinichiro 
Published: April 2024

AbstractAn approach for the synthesis of cyclic phosphotriesters with various ring sizes (5‐ to 8‐membered rings) from phosphorus trichloride and diols was developed. The major challenge in developing this approach is the suppression of the undesired reactions caused by substrates containing multiple highly reactive sites. These undesired reactions were successfully suppressed by microflow technology, which can precisely control the reaction time and temperature. Two optimal conditions were developed, depending on the speed of cyclization. Fifteen cyclic phosphotriesters and their analogs were synthesized. A plausible mechanism for suppressing undesired reactions is proposed.
Robustly exponentially almost sure stabilization of uncertain discrete‐time composite switched systems
Authors: Gao Wenshuai , Song Yang 
Published: April 2024

AbstractThis paper is concerned with the robustly exponentially almost sure (EAS) stabilization of uncertain discrete‐time composite switched systems (CSSs), in which the dominant signal subjects to a semi‐Markov chain, while the subordinate signals follow a family of different Markov chains. Norm‐bounded uncertainties impacting the state and input matrices of the system are taken into account. Utilizing numerical computation methods, bounds on the transient statistical properties of Markov chain are provided. Based on this, sufficient conditions for robustly EAS stabilization are established by combining an estimate of the sojourn time for modes in a semi‐Markov chain. Our result is the discrete counterpart of prior work concerning continuous‐time dual‐switching systems. Two examples are provided to validate the effectiveness of developed results.
Observer‐based adaptive event‐triggered containment control of linear multiagent systems with non‐autonomous leaders
Authors: Zhao Xiao‐Wen , Deng Dong‐Dong , Ge Ming‐Feng , Liu Zhi‐Wei 
Published: April 2024

AbstractThis paper investigates the containment control problem of linear multiagent systems (MASs) with multiple non‐autonomous leaders on a directed graph. First, an event‐triggered compensator is designed for each follower to estimate the convex combination of non‐autonomous leaders' states. The compensator is designed with the following three features: (1) It can estimate the convex combination of non‐autonomous leaders' states over directed graphs; (2) it is fully distributed; and (3) the designed event‐triggered mechanisms (ETMs) are composite dynamic ETMs, and each follower does not have to monitor the sampling errors continuously. Then, a state observer is developed for each follower based on the output feedback. Based on the designed compensator and state observer, an event‐triggered controller is developed, ensuring that each follower's state converges exponentially to an arbitrarily small neighborhood centered on the convex combination of leaders' states. Additionally, the proposed DETMs are free of Zeno behavior. Finally, the effectiveness of the developed control protocol is verified by two simulation examples.
‘I am not what you label me’: Senses of belonging in a mainland Chinese university among cross‐border Hong Kong students
Authors: Gao Fang 
Published: April 2024

AbstractChina's grand strategies (i.e., the Belt and Road Initiative and the Guangdong–Hong Kong–Macao Greater Bay Area) have expedited the popularity of full‐time degree‐bearing study in mainland China. Associated with the exponential growth of inward student populations are proliferating concerns about the capacity of non‐majority/non‐local students to ‘integrate’ and belong in their host universities/colleges. The extant literature on university/college belonging often positions non‐majority/non‐local students as being academically and culturally deficient and subsequently being otherised in the host university community. Yet, their agency in managing the prevailing image and ‘otherisation’, and constructing their own sense of belonging to university, has received scant attention. This qualitative study is a substantive and theoretical contribution to the literature on university belonging, which has been preoccupied with non‐majority/non‐local students in the classic South–North international student mobility. This study deployed the concepts of politics of belonging and place‐belongingness and canvassed the senses of belonging to university among inbound Hong Kong students in mainland higher education, which has witnessed a growing Hong Kong student population in recent years. The collected interview data indicated that these border‐crossing Hong Kong students found themselves categorised as ‘underachievers’ with ‘poor mathematics’ yet ‘proficient in English’ in the mainland campus setting, where they did not feel they fully belonged. Responding to the paradoxical identity/belonging politics, they performed three forms of place‐belongingness by dismantling, accommodating or counter‐stereotyping the ascribed classifications in order to legitimate their own participation in the mainland Chinese university.
The effects of sensory integration on stereotypy of preschool students with autism
Authors: Nuzzolo Robin , Walker Hannah 
Published: April 2024

AbstractThe purpose of the current study was to systematically replicate the independent variable used in Moore et al.'s (2015) experiment using sensory integration therapy (SIT) as a treatment for automatically maintained stereotypy. According to sensory integration theory, providing certain sensory experiences to individuals with autism can change their repetitive behavior. Despite the lack of research supporting SIT as a valid treatment to reduce episodes of stereotypy in individuals with autism spectrum disorder (ASD), it remains a common treatment in most schools and centers designed for these individuals. The study was conducted with three preschool students with ASD using a multiple baseline design across participants to test for a functional relation between the independent variable, the participants' individualized, prescribed sensory diets and the dependent variable, their episodes of stereotypy in morning and afternoon sessions. The results do not support the use of a sensory diet as a treatment for stereotypy.
LC–MS/MS method for quick detection of vonoprazan fumarate in human plasma: Development, validation and its application to a bioequivalence study
Authors: Chen Xinyan , Chen Tao , Huang Yunzhe , Wang Minhui , Wang Yaqin , Wu Ping , Xia Xiaocui , Du Pengfei , Wu Jianbang , Shen Jie , Jia Yuanwei 
Published: April 2024

AbstractA liquid chromatography–tandem mass spectrometry method with vonoprazan fumarate‐d4 as a stable isotope‐labeled internal standard was developed and validated aiming at quantification of vonoprazan fumarate in human plasma for a bioequivalence study. Chromatographic separation was achieved by acetonitrile one‐step protein precipitation using a gradient elution of 0.1% formic acid aqueous solution and acetonitrile with a run time of 3.65 min. Detection was carried out on a tandem mass spectrometer in multiple reaction monitoring mode via a positive electrospray ionization interface. The multiple reaction monitoring mode of precursor–product ion transitions for vonoprazan fumarate and vonoprazan fumarate‐d4 were m/z 346.0 → 315.1 and 350.0 → 316.0, respectively. The linear range was 0.150–60.000 ng/ml. This method was fully validated with acceptable results in terms of selectivity, carryover, lower limit of quantification, calibration curve, accuracy, precision, dilution effect, matrix effect, stability, recovery and incurred sample reanalysis. A successful application of this method was realized in the bioequivalence study of vonoprazan fumarate tablet (20 mg) among healthy Chinese volunteers.
Digital application for drug product potency target evaluation in biopharmaceutical manufacturing
Authors: Shen Darrick , Panjwani Shyam , Spetsieris Konstantinos 
Published: April 2024

AbstractBiopharmaceutical manufacturing entails a series of highly regulated steps. The manufacturing of safe and efficacious drug product (DP) requires testing of critical quality attributes (CQAs) against specification limits. DP potency concentration, which measures the dosage strength of a particular DP, is a CQA of great interest. In order to minimize the DP potency out‐of‐specification (OOS) risk, sterile fill finish (SFF) process adjustments may be needed. Varying the potency targets can be one such process adjustment. To facilitate such evaluation, data acquisition and statistical calculations are required. Regularly conducting the OOS risk assessment manually using commercial statistical software can be tedious, error‐prone, and impractical, especially when several alternate potency targets are under consideration. In this work, the development of a novel framework for OOS risk assessment and deployment of cloud‐based statistical software application to facilitate the risk assessment are presented. This application is intended to streamline the assessment of alternate potency targets for DP in biologics manufacturing. The major aspects of this potency targeting application development are presented in detail. Specifically, data sources, pipeline, application architecture, back‐end and front‐end development as well as application verification are discussed. Finally, several use cases are presented to highlight the application's utility in biologics manufacturing.
Metal‐Organic Framework‐Based Composites for Rapid and Sensitive Virus Detection: Current Status and Future Prospective
Authors: ElGazar Aya , Sabouni Rana , Ghommem Mehdi 
Published: April 2024

AbstractThe current spread of various viruses has negatively affected human life and health. Developing enhanced virus diagnostic techniques to mitigate future outbreaks is becoming vital. Metal‐organic frameworks (MOFs) have gained significant attention for their potential applications in virus detection because of their outstanding features, including high surface area, tunable properties, and adjustable pore size. Integrating nanomaterials with MOFs can also further enhance these properties, creating a new class of materials referred to as MOF‐based nanocomposites. This review paper provides an overview of the MOF‐based nanocomposites' status and future prospects for enhanced virus detection. The recent advances in the synthesis and functionalization of MOF and MOF‐based nanocomposites for virus detection are discussed. The paper describes the different types of detection platforms, including nucleic acid and immunological detection, as well as the mechanisms of MOF‐based sensors and the techniques used to synthesize MOFs and MOF‐based nanocomposites for virus detection. Additionally, the review paper explores the potential of integrating MOFs into real sensing devices and their prospects in real‐life applications. Finally, the paper examines the current challenges of these biosensing platforms. Overall, the review paper highlights the capability of MOFs and MOF‐based nanocomposites as versatile and practical platforms for virus detection and provides a comprehensive overview of the latest advancements in this area of research.
Subcutaneous fibroblastoma resembling hemangioma: A case of benign tumor of the chest wall
Authors: Zubair Rabbia , Zulfi Muhammad Hassan , Yaqoob Úzair , Lee Ka Yiu 
Published: April 2024

Key Clinical MessageDesmoplastic fibroma presents similar to other soft tissue tumors to such an extent that even a gold standard investigation can miss.AbstractThis is to report a mass in a 47‐year‐old male arising from the chest wall, which was first thought to be a hemangioma but was later diagnosed as a case of desmoplastic fibroblastoma with the help of a biopsy.
A case of secondary pseudohypoaldosteronism that presented as poor weight gain
Authors: Goshima Keisuke , Tamura Hiroshi , Hidaka Yuko , Furuie Keishiro , Kuraoka Shohei 
Published: April 2024

Key clinical messagePseudohypoaldosteronism (PHA) carries a good prognosis if treated early and appropriately, but some cases can have life‐threatening events. We underscored the need to consider secondary PHA as one of the differential diagnoses of hyponatremia and hyperkalemia in infancy.AbstractPseudohypoaldosteronism (PHA) type 1 has two classifications; the primary type, caused by genetic abnormalities that develop during neonatal and infancy periods, and the secondary type, caused by urinary tract malformation and urinary tract infection. Secondary PHA, if treated early and appropriately, has a good prognosis; however, some cases can present life‐threatening events. Therefore, early diagnosis is crucial. We present a case of early infancy secondary PHA presented with marked hyponatremia and poor weight gain. The patient's growth and development improved with secondary PHA treatment. Here, were demonstrated the value of prompt action against infection and electrolyte imbalance and the importance of imaging for diagnosis, and underscore the need to consider secondary PHA as a differential diagnoses of hyponatremia and hyperkalemia in infancy. However further studies, including basic research, to elucidate the diseases pathology is warranted.
Successful treatment of a high‐risk diabetic foot ulcer by ozone therapy and collagen powder: A case report
Authors: Talebi Hooman Mohammad , Javaheri Javad , Fakhari Mohammad Sadegh 
Published: April 2024

Key Clinical MessageA high risk diabetic foot ulcer is treated by ozone therapy and collagen powder. The goal of this study was to report a high risk case, treated by ozone therapy, and collagen powder. Ozone therapy and collagen powder can improve healing process of diabetic foot ulcers.AbstractThis case report presents a successful nonsurgical outpatient approach for managing a high‐risk diabetic foot ulcer with tendon exposure in an older adult with uncontrolled diabetes mellitus and severe heart failure. Due to the patient's comorbidities, surgical intervention was not an option, leading to the utilization of ozone therapy, collagen powder, and Phenytoin ointment. The significance of this case lies in the treatment of a high‐risk foot ulcer through a nonsurgical approach, considering the patient's uncontrolled diabetes and severe heart failure. Diabetic foot ulcers (DFUs) are debilitating and life‐threatening complications, often resulting in amputations, socio‐psychological burdens, and lifestyle changes. Conventional treatment methods have shown limited success, necessitating the exploration of new and innovative approaches. The use of ozone therapy has emerged as a potential treatment, but its safety and efficacy in DFUs require further investigation. The positive outcomes observed in this case report suggest that ozone therapy may be a viable option for treating DFUs, and further studies are recommended to evaluate its effectiveness.
Removal of Metal Ions from Wastewater Using Co‐integrated Superparamagnetic Nanoparticles
Authors: Vishnu Dhanya , Dhandapani Balaji , Vijayasimhan Sivapriya , Rajendran Arasi , Mukunthan Madhav , Pandiyan Mohan , Shankar Aadithya , Senthilkumar K. 
Published: April 2024

AbstractThe column performance of silica‐coated, amino‐functionalized, superparamagnetic nanoparticles co‐integrated with Cynodon dactylon and Murraya koenigii plant extracts for the removal of CuII ions was evaluated. The co‐integrated nanoparticles were used as sorbent materials in fixed‐bed column studies, and the effects of inlet concentration, adsorbent bed depth, and flow rate were analyzed. Breakthrough time was calculated for various CuII inlet concentrations, depths of the adsorbent bed, and volumetric flow rates. Models such as Thomas, Yoon‐Nelson, and the bed depth model were evaluated to determine the experimental fit. The maximum breakthrough time for CuII ions of 1200 min was attained for a CuII inlet concentration of 100 mg L–1, sorbent bed depth of 3 cm, and volumetric flow rate of 1 mL min–1.
Source Apportionment and Pollution Assessment of Heavy Metals in an Urban Waterbody
Authors: Priya Lakshmi , Siddik A Muhammed , Varghese George K. 
Published: April 2024

AbstractWith increasing contamination of waterbodies, access to clean drinking water has become a challenge. Preventing further contamination and cleaning up of existing contamination are the immediate steps to address this challenge. For this, the sources of contamination and their relative contributions need to be ascertained. The bottom sediments from an urban waterbody named “Conolly Canal” was analyzed for heavy metal contamination. The level of contamination of the waterbody was assessed using Pollution Load Index. A Monte Carlo analysis (MCA) was performed on the heavy metals concentrations measured to apportion the contribution among the identified sources. The results of MCA were used to proportion the concentration of chemicals among the responsible parties based on the concentration of the contaminants in the waterbody. The study presents a robust procedure for source apportionment, which can be adopted in similar situations.
Emergent Properties in Chemistry ‐ Relating Molecular Properties to Bulk Behavior
Authors: Sieroka Norman , Lossau Tammo , Neudecker Tim 
Published: April 2024

AbstractCertain properties of an object only emerge when a sufficient number of those objects are present in a definite arrangement. For example, one or two water molecules cannot said to be in a liquid state, but a drop of water can be. This concept of emergence has been studied extensively, but only occasionally discussed explicitly in the context of chemistry. In this paper, we aim to show the fruitfulness of the concept of emergence for chemical inquiry by considering four case studies of emergent chemical properties, i. e., the liquidity and freezing of water, structural properties of crystals, thermodynamical phase transitions and quantum mechanical phenomena. We show that some of these properties emerge gradually, some at discrete points, and some should be taken to emerge only when the number of constituents tends to infinity. We argue that studying the way in which chemical properties emerge presents a useful avenue for research that promises greater insight into the nature of those properties.
Electron Donor‐Acceptor Complex Driven Photocatalyst‐Free Trifluoromethylation of Heterocycles
Authors: Li Yufei , Hou Jie , Zhang Pei , Dai Peng , Gu Yu‐Cheng , Xia Qing , Zhang Weihua 
Published: April 2024

AbstractHeterocyclic trifluoromethylation is efficiently initiated through a photochemical reaction utilizing an electron donor–acceptor (EDA) complex, proceeding smoothly without the use of photocatalysts, transition‐metal catalysts, or additional oxidants. This method has been optimized through extensive experimentation, demonstrating its versatility and efficacy across various substrates, including quinoxalinones, coumarins, and indolones. Notably, this approach enables the practical synthesis of trifluoromethylated quinoxalinones on a gram scale. Mechanistic investigations that incorporate radical trapping and ultraviolet/visible spectroscopy, confirmed the formation of the an EDA complex and elucidated the reaction pathways. This study highlights the crucial role of EDA photoactivation in trifluoromethylation, significantly expanding the application scope of EDA complexes in chemical synthesis.