bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential of hospital wastewater treatment using locally isolated Chlorella sp. LH2 from cocoon wastewater
Authors: Le Tu Thi Anh , Nguyen Truong 
Published: April 2024

AbstractChlorella sp. is able to grow and transform inorganic and organic contaminants in wastewater to create biomass. In the present study, Chlorella sp. LH2 isolated from cocoon wastewater was able to thrive in hospital wastewater, then remove nutrients and eliminate E. coli ATCC 8739. The results indicated that optimal cultivation conditions of Chlorella sp. LH2 in hospital wastewater were pH of 8, light:dark cycle of 16:8 at 30oC. The inhibitory effect of chlorination on algae growth was accompanied with the chlorine concentration. BOD5:COD ratio of 0.77 indicated biodegradability of hospital wastewater. The untreated and treated wastewatee samples were collected to investigated the nutrient removal efficiency after 10 days. Untreated and treated results were192 ± 8.62 mg/l 23.91 ± 2.19 mg/l for BOD5; 245 ± 9.15 mg/l and 47.31 ± 5.71 mg/l for COD. The treated value met the required standards for hospital wastewater treatment. The removal efficiency total nitrogen and total phosphorus were 68.64% and 64.44% after 10 days, respectively. Elimination of E. coli ATCC 8739 after 7 days by Chlorella sp. LH2 was 88.92%. The results of this study suggest the nutrients and pathogens removal potential of Chlorella sp. LH2 in hospital wastewater for further practical applications.
A study protocol for a feasibility randomised controlled trial investigating videoendoscopic radical inguinal lymphadenectomy versus open radical inguinal lymphadenectomy in patients with penile cancer (VELRAD)
Authors: Tang Stanley , Akers Clare , Alnajjar Hussain , Ayres Ben , Baldini Cinzia , Embleton-Thirsk Andrew , Gurusamy Kurinchi , Hadway Paul , Kumar Vivekanandan , Lau Maurice , Nigam Raj , Pang Karl , Parnham Arie , Pizzo Elena , Ranieri Veronica , Rees Rowland , Sangar Vijay , Wadke Anvi , Williams Norman , Muneer Asif 
Published: April 2024

Abstract
Background
Penile cancer is a rare male genital malignancy. Surgical excision of the primary tumour is followed by radical inguinal lymphadenectomy if there is metastatic disease detected by biopsy, fine needle aspiration cytology (FNAC) or following sentinel lymph node biopsy in patients with impalpable disease. However, radical inguinal lymphadenectomy is associated with a high morbidity rate, and there is increasing usage of a videoendoscopic approach as an alternative.

Methods
A pragmatic, UK-wide multicentre feasibility randomised controlled trial (RCT), comparing videoendoscopic radical inguinal lymphadenectomy versus open radical inguinal lymphadenectomy. Patients will be identified and recruited from supraregional multi-disciplinary team meetings (sMDT) and must be aged 18 or over requiring inguinal lymphadenectomy, with no contraindications to surgical intervention for their cancer. Participants will be followed up for 6 months following randomisation. The primary outcome is the ability to recruit patients for randomisation across all selected sites and the rate of loss to follow-up. Other outcomes include acceptability of the trial and intervention to patients and healthcare professionals assessed by qualitative research and obtaining resource utilisation information for health economic analysis.

Discussion
There are currently no other published RCTs comparing videoendoscopic versus open radical inguinal lymphadenectomy. Ongoing study is required to determine whether randomising patients to either procedure is feasible and acceptable to patients. The results of this study may determine the design of a subsequent trial.

Trial registration
Clinicaltrials.gov PRS registry, registration number NCT05592639. Date of registration: 13th October 2022, retrospectively registered
A comprehensive pediatric cardio-oncology program: a single institution approach to cardiovascular care for pediatric patients with cancer and childhood cancer survivors
Authors: Hernandez Nathanya Baez , Shliakhtsitsava Ksenya , Tolani Drishti , Cochran Cindy , Butts Ryan , Bonifacio Judith , Journey Elizabeth , Oppenheim Jenna N. , Pennant Sarah G. , Arnold Kimberly , McCaskill Terri , Bowers Daniel C. 
Published: April 2024

AbstractCardiovascular complications related to cancer therapies are broad and variable in onset. These complications are the leading cause of non-cancer related morbidity and mortality in childhood cancer survivors and can also impact ongoing cancer treatment. Despite this understanding, dedicated cardio-oncology programs are lacking in pediatric cardiology. In an attempt to respond to these concerns, a risk-stratified, comprehensive cardio-oncology program was established to address the cardiovascular needs including prevention, early diagnosis, and management of patients with and at risk for cardiovascular complications of cancer therapy. This manuscript describes a single institution’s experience of building and managing a multidisciplinary pediatric cardio-oncology program with close collaboration among cardiologists, oncologists, advanced cardiology and oncology practice providers, and allied health providers such as a dietitian and psychologist to provide comprehensive cardiovascular care for childhood cancer patients and survivors. In developing this program, emphasis was on the childhood cancer survivor population, as various cardiovascular complications can present many years after cancer treatment.
Emergency airway management in the prone position: an observational mannequin-based simulation study
Authors: Rajaleelan Wesley , Tuyishime Eugene , Plitman Eric , Unger Zoe , Venkataraghavan Lakshmi , Dinsmore Michael 
Published: April 2024

Abstract
Introduction
Accidental extubation during prone position can be a life-threatening emergency requiring rapid establishment of the airway. However, there is limited evidence of the best airway rescue method for this potentially catastrophic emergency. The aim of this study was to determine the most effective method to recover the airway in case of accidental extubation during prone positioning by comparing three techniques (supraglottic airway, video laryngoscopy, and fiber-optic bronchoscopy) in a simulated environment.

Methods
Eleven anesthesiologists and 12 anesthesia fellows performed the simulated airway management using 3 different techniques on a mannequin positioned prone in head pins. Time required for definitive airway management and the success rates were measured.

Results
The success rates of airway rescue were 100% with the supraglottic airway device (SAD), 69.6% with the video laryngoscope (CMAC), and 91.3% with the FOB. The mean (SD) time to insertion was 18.1 (4.8) s for the supraglottic airway, 78.3 (32.0) s for the CMAC, and 57.3 (24.6) s for the FOB. There were significant differences in the time required for definitive airway management between the SAD and FOB (t = 5.79, p < 0.001, 95% CI = 25.92–52.38), the SAD and CMAC (t = 8.90, p < 0.001, 95% CI = 46.93–73.40), and the FOB and CMAC (t = 3.11, p = 0.003, 95% CI = 7.78–34.25).

Conclusion
The results of this simulation-based study suggest that the SAD I-gel is the best technique to manage accidental extubation during prone position by establishing a temporary airway with excellent success rate and shorter procedure time. When comparing techniques for securing a definitive airway, the FOB was more successful than the CMAC.
Positive effect of lippia sidoides essential oil associated with carboxymethylcellulose in the control of anthracnose in avocado
Authors: Antonia Barbara Della , de Oliveira Jacqueline , da Silva Paula Porrelli Moreira , dos Mares Biazotto Anaíle , de Toledo Nataly Maria Viva , da Glória Eduardo Micotti , Spoto Marta Helena Fillet 
Published: April 2024

AbstractThe fungus Colletotrichum gloeosporioides, which is the causal agent of anthracnose disease in green-skinned avocados, is responsible for significant postharvest fruit losses. In this context, strategies should be considered to avoid this problem. The use of essential oil (EO) can represent an alternative to contribute to antifungal activity, avoiding the use of chemical products, as their indiscriminate use can have harmful effects on human health. It is known that essential oil (EO) may exhibit antifungal activity and can be used as an alternative to chemical products. Therefore, the potential of using Lippia sidoides EO to control this fungus was investigated through in vitro evaluation (MIC and EC50) on C. gloeosporioides isolated from avocados. Furthermore, the potential of incorporating this oil with carboxymethylcellulose (CMC) for postharvest treatment in avocados was assessed in vivo to control anthracnose and maintain their physicochemical and sensory quality. The EO from L. sidoides demonstrated a MIC of 125 μl L−1 and an EC50 of 46.83 μl L−1 against this pathogen. The results indicated that the CMC edible coating associated with L. sidoides EO exhibited a positive effect on fruit quality during cold storage. In terms of sensory aspects, avocados treated with L. sidoides EO associated with CMC showed improved appearance compared to the control treatment. These findings suggest that L. sidoides EO has potential in the postharvest treatment of avocados. Additionally, these results are significant and unprecedented for this crop, as research on the postharvest effects of incorporating this EO with edible coatings in avocados is still limited.
Graphical Abstract
Endoscopic Endonasal Transsphenoidal Resection of Pituitary Adenomas in Patients Presenting With Monocular Blindness
Authors: Gomez David , Cheok Stephanie , Feng Jeffrey J. , Chung Ryan , Pangal Dhiraj J. , Ruzevick Jacob J , Gokoffski Kimberly K. , Shiroishi Mark S. , Wrobel Bozena B. , Carmichael John D. , Zada Gabriel 
Published: April 2024

BACKGROUND AND OBJECTIVES:
Suprasellar tumors, particularly pituitary adenomas (PAs), commonly present with visual decline, and the endoscopic endonasal transsphenoidal approach (EETA) is the primary management for optic apparatus decompression. Patients presenting with complete preoperative monocular blindness comprise a high-risk subgroup, given concern for complete blindness. This retrospective cohort study evaluates outcomes after EETA for patients with PA presenting with monocular blindness.

METHODS:
Retrospective analysis of all EETA cases at our institution from June 2012 to August 2023 was performed. Inclusion criteria included adults with confirmed PA and complete monocular blindness, defined as no light perception, and a relative afferent pupillary defect secondary to tumor mass effect.

RESULTS:
Our cohort includes 15 patients (9 males, 6 females), comprising 2.4% of the overall PA cohort screened. The mean tumor diameter was 3.8 cm, with 6 being giant PAs (>4 cm). The mean duration of preoperative monocular blindness was 568 days. Additional symptoms included contralateral visual field defects (n = 11) and headaches (n = 10). Two patients presented with subacute PA apoplexy. Gross total resection was achieved in 46% of patients, reflecting tumor size and invasiveness. Postoperatively, 2 patients experienced improvement in their effectively blind eye and 2 had improved visual fields of the contralateral eye. Those with improvements were operated within 10 days of presentation, and no patients experienced worsened vision.

CONCLUSION:
This is the first series of EETA outcomes in patients with higher-risk PA with monocular blindness on presentation. In these extensive lesions, vision remained stable for most without further decline and improvement from monocular blindness was observed in a small subset of patients with no light perception and relative afferent pupillary defect. Timing from vision loss to surgical intervention seemed to be associated with improvement. From a surgical perspective, caution is warranted to protect remaining vision and we conclude that EETA is safe in the management of these patients.
Gestational diabetes mellitus as a risk factor for future Type-2 diabetes mellitus: An experience from a tertiary care diabetes hospital, Karachi - Pakistan
Authors: Riaz Musarrat , Waris Nazish , Saadat Akifa , Fawwad Asher , Basit Abdul 
Published: April 2024

Objective: To evaluate the history of gestational diabetes mellitus and other risk factors in women presenting with Type-2 diabetes mellitus at a tertiary care hospital.
Methods: This cross-sectional study was carried out at Baqai Institute of Diabetology & Endocrinology (BIDE), Baqai Medical University (BMU), Karachi-Pakistan from July 2019 to May 2022. Women with Type-2 diabetes mellitus (T2DM) visiting outpatient department of BIDE with a previous history of GDM were recruited. Details were obtained on pre-designed questionnaire after taking informed written consent.
Results: A total of 378 women who had a prior history of GDM were included. Mean age (years) was 43.53±10.17. Mostly women were obese (BMI = 30.53±6.08) and have sedentary lifestyle. Mean HbA1c (%) was 9.08±2.24. This study found family history of T2DM and hypertension were common risk factors in women with GDM history. Mostly, women were diagnosed as GDM during 2nd trimester 153(42%) and was mainly seen in multiparous women (occur in 4th and above pregnancy). We found hypertension as common complication during pregnancy. Around 46% women developed T2DM within one year of GDM diagnosis, and 29.6% between one to five years.
Conclusion: Majority of women with GDM developed T2DM within five years of diagnosis. The potential associated risk factors were age, family history of diabetes, insulin use during pregnancy, trimester of GDM diagnosis, and hypertension during pregnancy. Awareness and life style modifications along with regular post-partum follow up with screening for T2DM should be part of GDM management to prevent or delay the occurrence of this serious complication.
doi: https://doi.org/10.12669/pjms.40.5.7507
How to cite this: Riaz M, Waris N, Saadat A, Fawwad A, Basit A. Gestational diabetes mellitus as a risk factor for future Type-2 diabetes mellitus: An experience from a tertiary care diabetes hospital, Karachi - Pakistan. Pak J Med Sci. 2024;40(5):---------. doi: https://doi.org/10.12669/pjms.40.5.7507
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Eugène Rodolphe Faribault: Nova Scotia Gold Icon
Authors: Mossman David 
Published: April 2024

Eugène Rodolphe Faribault proved to be a very good choice as a geologist for the Geological Survey of Canada, after his appointment on July 1, 1883. His career spanned fifty years, time mostly committed to mapping the southwestern half of Nova Scotia, concentrated on the slate and quartzite of the Meguma Supergroup in which gold mining was taking place. In his words, he was, “a specialist on geological maps and structural geology of gold mines in Nova Scotia”. Dozens of his meticulously prepared maps of over sixty gold districts have stood the test of time for accuracy. A popular figure in the field, Faribault made frequent trips to operating mines. He early recognized the existence, in some districts, of extensive bodies of low-grade ore. He emphasized too, the similarities between the ‘saddle reef’ deposits mined in the Bendigo fields of Australia and the auriferous veins of the Meguma formations. His ‘pay-zone’ theory held that near-surface mineable ore in Nova Scotia gold mines should continue at depth, provided the same structural conditions persisted. However, for various reasons his theory received a mixed reception. Back in Ottawa at the GSC offices, Faribault was a highly respected figure among fellow workers and supervisors alike, and across all departments. His quiet charisma and friendly nature, complemented by professional expertise, won him accolades as an ambassador well beyond the workplace. For his excellence in a young developing science, Faribault thoroughly earned the epithet, “The Grand Old Man of Nova Scotian Geology”.
Nd:YAG water mist laser treatment for giant gestational gingival tumor: A case report
Authors: Chen Hong-Yu , Xu Jun-Ji , Chang Xiu-Lin , Wu Pei 
Published: April 2024

BACKGROUND
This case of gestational gingival tumor is huge and extremely rare in clinical practice. As the growth location of this gingival tumor is in the upper anterior tooth area, it seriously affects the pregnant woman's speech and food, causing great pain to the patient. The use of Nd:YGA water mist laser to remove the gingival tumor resulted in minimal intraoperative bleeding, minimal adverse reactions, and good postoperative healing, which is worthy of clinical promotion and application.
CASE SUMMARY
The patient, a pregnant woman, reported a large lump in her mouth on the first day of postpartum treatment. Based on medical history and clinical examination, the diagnosis was diagnosed as gestational gingival tumor. Postoperative pathological biopsy also confirmed this diagnosis. The use of Nd:YAG water mist laser to remove the tumor resulted in minimal intraoperative bleeding, clear surgical field of view, short surgical time, and good postoperative healing.
CONCLUSION
In comparison to traditional surgery, Nd:YAG water mist laser surgery is minimally invasive, minimizes cell damage, reduces bleeding, ensures a clear field of vision, and virtually eliminates postoperative edema, carbonization, and the risk of cross infection. It has unique advantages in oral soft tissue surgery for pregnant patients. Therefore, the clinical application of Nd:YAG water mist laser for the treatment of gestational gingival tumors is an ideal choice.
Emotional Intelligence and Success in Initial Vocational Education and Training: A Study Among Healthcare Assistants and Social Care Workers
Authors: Tremonte-Freydefont Laure , Wenger Matilde , Fiori Marina 
Published: April 2024

Context: Research on emotional intelligence (EI) shows this concept's decades-long positive influence on well-being, self-efficacy, employability, and academic and professional achievement. Indeed, several studies have demonstrated that students with high EI have better grades and quality of life, as well as are more employable than students with low EI. By considering the two conceptualizations of EI as either an ability or personality trait, the present study investigates EI's influence on training achievement in initial vocational education and training (IVET). We posited that the two types of EI positively influence training achievement in a complementary way: Ability EI relates to achievement in theoretical training, while trait EI relates to achievement in practical training. Furthermore, these links are mediated by apprentices' engagement at school and in learning.
Method: To test our hypotheses, 92 dual IVET health and social care apprentices in their last year of vocational school completed an online survey composed of validated scales measuring EI as an ability, EI as a personality trait, personality traits, and school engagement. The apprentices' grades were also obtained with their permission.
Results: The findings confirmed our hypotheses and reflected EI's positive influence on training achievement. We observed that participants with high EI (as an ability and personality trait) obtained better grades than participants with lower EI. Moreover, our results showed that ability EI has a direct influence on achievement in theoretical health and social care training, while the link between trait EI and practical training is indirect and mediated by engagement in learning.
Conclusion: The present study confirms EI's positive influence on school achievement in the VET context and further corroborates the important role that EI can play in dual IVET apprentices' achievement, particularly in the health and social sectors. This original study contributes to research on the VET system by placing EI among the skills necessary to ensure professional success.
Engaging Young People in Occupations Served by Vocational Education: Case Study From Healthcare
Authors: Billett Stephen , Le Anh Hai 
Published: April 2024

Purpose: Globally, countries with both developed and developing economies are struggling to secure sufficient participation in vocational education to generate the range and quantum of skills required for their communities and realising national social and economic goals. In an era of high aspiration, vocational education and the occupations it serves are increasingly seen as being a less than desirable outcome by young people and their parents. Hence, there is a need to identify means by which to inform and engage young people in considering vocational education and the occupations it serves. The case study discussed in this paper is contextualised within the Australian state of Queensland, which, like many other countries is struggling to have a workforce sufficient to meet communities' healthcare needs as its population both grows and ages.
Methods: The study data were collected from 1) interviews with healthcare-related stakeholders including health industry representatives, teachers or practitioners, and healthcare providers, 2) focus groups with senior secondary students, and 3) surveys with these participant groups. It provides a descriptive analysis of efforts to secure greater participation by young people in allied health roles, and, in particular, young Australian Indigenous people.
Findings: The study participants included those from regional and metropolitan centres and from state and independent schools, and in all of which the focus on engagement was central. Findings indicated that engagement was necessary to advise young people about these occupations, the effective preparation for them, and likely retention in the workforce.
Conclusion: This study highlights the need for intentional strategies to engage young people, their parents/guardians and with those efforts likely needing to be organised and enacted at the local level. This requires collaboration and engagement from education, industry, and local communities. Essentially, a systemic approach is required, specifying roles for government, employers, educational systems, and teachers and parents who engage directly with young people. In all, engagement, advice and opportunities locally are all emphasised in the study reported here.