bluuebunny/crossref_metadata_2025_split huggingface dataset:
Die Kastanie im Engadin – oder was halten Baumarten von modellierten Potenzialgebieten? Chestnut in the Engadine – what do tree species think about model predictions?
Authors: Zimmermann Niklaus E. , Bugmann Harald 
Published: October 2008

New IPCC climate projections suggest drastic changes in future climate. We discuss two commonly used modeling approaches, statistical distribution models and dynamic forest succession models, as they are suitable for assessing expected effects of climate change on the tree species distribution in Switzerland and for assisting management decisions in forestry. We discuss the basic assumptions and the strengths and weaknesses of the two approaches, without an understanding of which it is impossible to fully judge the outcome of modeling exercises. We give an overview of results from applying these two modeling approaches in Switzerland and in the Alps and discuss their appropriate use.
We believe that these models are an important basis for decision making in the face of highly uncertain development of future climate. Nonetheless, models do not represent an exact copy of reality. Plausibility analyses are necessary in order to assess the results' usefulness and precision. Sensitivity analyses and a critical comparison of model results with expert knowledge of current forests, long measurement time series and other data are important. Also, dialog with practitioners and managers is not only important for checking the plausibility of model predictions under current conditions, but may also serve to improve the evaluation of future projections. We propose to apply models to the whole of Switzerland and to many tree species. Such a concerted national analysis may serve the adaptive management of forests and may strengthen dialog between researchers and practitioners.
Effekte des Klimawandels auf Windwurf, Waldbrand und Walddynamik im Schweizer Wald | Effects of climate change on windthrow, forest fire and forest dynamics in Swiss forests
Authors: Wohlgemuth Thomas , Conedera Marco , Albisetti Andrea Kupferschmid , Moser Barbara , Usbeck Tilo , Brang Peter , Dobbertin Matthias 
Published: October 2008

Most natural disturbances to Swiss forests are caused by climatically induced extreme events: winter storms, foehn and thunderstorms predominate in the North of the Alps, and forest fires in the Southern Alps. Many studies predict a general increase of these extreme events under continued climatic change. How resistant are Swiss forests against wind and fire disturbance, and how resilient are they after disturbance? Because in Switzerland most of the severe winds happen in the wintertime, conifers such as Norway spruce and silver fir are the most vulnerable species. Beyond gust speeds of more than 40 m/s, all tree species are damaged. The fire resistance of forests depends on the flammability, which will increase due to increasing drought frequency. Forests in the Ticino will be most affected by this development, and to a lesser extent also forests in the Central Alps and those north of the Alps. After wind and fire disturbance, forest has re-established in almost all regions of Switzerland. Results from various studies in disturbed forests show that the amount of tree regeneration decreases with increasing elevation (R2 = 0.31). After fire, the speed of regeneration depends on various factors such as tree species, drought and the transient absence of mycorrhiza.
The natural regeneration process after severe forest disturbances reflects a first step towards a forest more adapted to the future. Trees that establish in big gaps and under repeated drought may resist the future climate.
Forstliche Schadorganismen im Zeichen des Klimawandels | Effects of climate change on forest pests and diseases
Authors: Engesser Roland , Forster Beat , Meier Franz , Wermelinger Beat 
Published: October 2008

The predicted increase in temperature, dry summers, and extreme meteorological events will affect many harmful species both by directly accelerating their propagation rates as well as by weakening their host plants. There might also be shifts in the interrelations in species communities that can hardly be predicted. Some fungal species, that had previously been inconspicuous, caused notable damages in the drought periods of the last two decades. Higher winter temperatures often increase the survival rates of many fungal and insect species. Because hot and dry summers are likely to become more frequent and heavy storms tend to occur more often, an increase in massive outbreaks of bark beetles with corresponding damage is to be expected. As a result of global trade, more invasive alien fungi and insects are introduced into Europe where the climatic conditions become more favorable for them to establish themselves on native or introduced host trees.
Insects and diseases can have a profound impact on forest dynamics. Therefore, these disturbances must be included in the discussion of future tree species composition and of forest development scenarios.
Ocyropsis‐Inspired Fast‐Swimming Transparent Soft Robots
Authors: Ye Zhiqiu , Yang Geng , Dai Huaixuan , Gan Yinliang , Jian Yihui , Xu Kaichen , Deen M. Jamal , Xia Jiaxu , Tian Nichen , Yang Yihong , Yang Huayong , Zhang Chao 
Published: February 2025

AbstractMarine creatures achieve effective survival in unstructured ocean environments via fast swimming or transparent camouflage. Aqueous soft robots, capable of reproducing soft features of marine creatures, have the advantages of safe biological interaction, high environmental adaptation, and noise‐free when compared with traditional rigid robots. Yet, there exists a persistent challenge to develop both fast and energy‐efficient aqueous soft robots that can achieve better underwater operation or exploration. Enlightened by the morphology and swimming strategy of Ocyropsis — a jellyfish‐like creature, Ocyropsis‐inspired robots (i.e., Ocyrobots) that merge electro‐hydraulic actuation and Ocyropsis‐type rowing mechanisms to achieve high‐performance underwater locomotion are developed. Ocyrobots demonstrate a record‐high speed of 1.1 body length/s, which is approximately three times of previously reported fastest jellyfish‐like robots while maintaining a low power consumption of 37 mW. Ocyrobots also exhibit an impressive turning speed of 34° s−1, enabling dexterous locomotion and effective obstacle avoidance in confined underwater scenarios. Attributed to the self‐developed highly reliable polymer‐based ionic gel, Ocyrobots possess remarkable advantages of full transparency and high durability, which improves their lifetime and reduces potential disturbances to underwater ecosystems. The unprecedented biomimetic idea in this study is essential in enlightening the prototyping of future aqueous soft robotics.
The Defects of Single Atom Co1‐N‐C Regulate the H‐Binding Energy to Achieve Divergent Hydrogen Evolution or Transfer Hydrogenation with HCOOH
Authors: Lv Shanshan , Zhou Yan , Yang Wenjuan , Song Manman , Li Feng , Feng Mengmeng , Chen Chen , Chen Zheng 
Published: February 2025

AbstractHCOOH can be used as a hydrogen donor in catalytic transfer hydrogenation (CTH) or a hydrogen storage molecule. The desorption‐combination of H* species from H‐binding sites after dissociation of HCOOH is necessary for hydrogen evolution reaction (HER) but undesired for CTH. In this work, it is found that the process of high‐temperature calcination can cause defects in the nitrogen‐doped carbon anchored single atom Co catalyst (Co1‐N‐C) and adjust the electronic state of Co, thereby affecting the H‐binding energy on single atom Co sites. The three‐coordinated single atom Co with the most abundant defects (def‐CoN3) has best catalytic activity in CTH of nitrobenzene using FA as hydrogen donor in reductive formylation reaction. While the single atom Co with minimal defects (CoN3) shows optimal HER efficiency of HCOOH than def‐CoN3 and four‐coordinated single atom Co. Through density functional theory calculation, the defective sites promoted the dissociation of HCOOH and H* absorption but inhibited the H* desorption, which is conducive to CTH. The H* is moderately absorbed on defect‐free CoN3 and easily desorbed to generate H2 molecule. The regulation on defect structures of single atom Co will provide new avenue for designing catalysts in catalytic processes involving H‐atom transfer.
Regulation of Ion Transport Behavior in Layer‐by‐Layer Assembled Polymer/MXene Heterostructure Anodes for Metal‐Free Aqueous Zinc Ion Batteries
Authors: Zhang Ruanye , Xu Hai , Li Zhemin , Dou Hui , Zhang Xiaogang 
Published: February 2025

AbstractRecently, the development of Zn‐host materials in metal‐free aqueous Zinc ion batteries (AZIBs) has emerged as an effective strategy to address the challenges of uncontrollable dendrite growth and severe corrosion in Zn anodes. Herein, the layer‐by‐layer assembly conjugated polyimide nanocomposite (PTN‐MXene) through in situ polymerization is proposed to realize high energy density and stability metal‐free AZIBs. Specifically, the unique layered structure and abundant redox centers of conjugated diketone‐based polyimide (PTN), combined with its high structural compatibility with MXene, enable the formation of a layer‐by‐layer assembled 2D/2D heterostructure. This design ensures sufficient contact and expands the interlayer spacing of MXene, facilitating faster electron/ion transport kinetics and providing better access to redox centers. Importantly, the regulation of ion transport behavior from H+ or Zn2+ to H+/Zn2+ coinsertion in PTN‐MXene is achieved and verified by different characterization techniques. Thus, PTN‐MXene anode exhibits high specific capacity (283.4 mAh g−1 at 0.1 A g−1), excellent rate performance and outstanding cycling performance. As a proof‐of‐concept, the full batteries fabricated by Prussian blue analogs cathode and PTN‐MXene anode deliver a high energy density of 72.4 Wh kg−1 and exceptional cycling stability over 2000 cycles.
TiO2 Anchored Cu Single Atoms Catalysts Boost Nitrite Electroreduction to Ammonia for Water Remediation
Authors: Sun Mingming , Wan Wenrui , Zhao Xiao , Shao Chunfeng , Liu Ning , Fan Maohong , Wang Jianji 
Published: February 2025

AbstractThe electrochemical conversion of harmful pollutant nitrite (NO2−) in wastewater to NH3 is an effective strategy for water remediation and production of value‐added chemicals. However, achieving high NH3 yield and selectivity is challenging due to the low catalyst activity and competitive H2 and N2H4 byproducts. Herein, for the first time, Cu single‐atom electrocatalysts on TiO2 (Cu1/TiO2) are designed for nitrite reduction to NH3 in a neutral aqueous electrolyte. The optimal Cu1/TiO2 exhibits an exceptional NH3 production rate of 21.2 mg h−1 mgcat−1 and a high NH3 Faradaic efficiency of 96.0% at −1.0 V (vs RHE), representing one of the best electrocatalytic performance ever achieved. Impressively, the NO2− (0.1 mol L−1) can be completely conversed in 8 h electrolysis. The experimental studies and theoretical calculations uncover that the single atoms Cu narrows the bandgap of TiO2 and improves the electron transfer in Cu1/TiO2, and the single‐atom Cu and TiO2 synergistically activate NO2−, stabilize the *NO intermediate, and reduce the energy barrier of the rate‐determining step (*NH3→NH3), thus resulting in remarkable electrocatalytic activity and selectivity for the reduction of nitrite to NH3. This study provides a new strategy for simultaneous NH3 production and water remediation at ambient conditions by using single‐atom catalysis.
Breathable, Moisturizing Biomimetic Wound Dressing with Broad‐Spectrum Antimicrobial Properties
Authors: Liu Yunge , Chen Xiao , Zhang Chengzhi , Li Saiya , Zheng Hui , Tang Wanting , Wang Qiannan , Liu Jinbo , Fang Kefan , Zhao Yingmin , Zhang Jing , Wang Dianyu 
Published: February 2025

AbstractMaintaining wound breathability and preventing infection are crucial for moist wound healing. However, existing hydrogel dressings suffer from poor breathability and clinically used antimicrobial agents such as antibiotics, metal nanoparticles, and natural antimicrobial substances face challenges including resistance, toxicity, and high extraction costs, respectively. Inspired by the antimicrobial properties of airway surface liquid (ASL), a biomimetic moisturizing and antibacterial hydrogel dressing (BMAHD) is designed. It combines polyvinyl alcohol (PVA) hydrogel with ordinary gauze to achieve high breathability, while also secreting a water‐glycerol mixture to moisturize the wound. Interestingly, Na2CO3 secreted by dressing achieves broad‐spectrum bactericidal effects, with up to 99% sterilization rates within 24 h. Furthermore, co‐cultivation experiments with mouse embryonic fibroblasts (L929) and sheep red blood cells (SRBC) demonstrate excellent cellular compatibility of the dressing. To prove of concept, the animal model confirms that BMAHD significantly promotes wound healing. The BMAHD provides a valuable reference for the design of novel medical dressings.
Blue Multiple‐Resonance Thermally Activated Delayed Fluorescence Materials
Authors: Cui Boyao , Zhou Jianqiao , Duan Chunbo , Xu Hui 
Published: February 2025

AbstractOrganic light‐emitting diodes (OLEDs) exhibit significant advantages in the fields of ultra‐high‐definition (UHD) displays and wearable devices. However, developing low‐cost, high‐efficiency, and high‐purity blue emission materials remains a significant challenge for academia and industry. While thermally activated delayed fluorescence (TADF) materials meet low‐cost manufacturing needs and achieve 100% internal quantum efficiency, their charge‐transfer excited states lead to broad emission spectra that don't meet the BT.2020 standard. Fortunately, the multiple resonance (MR) strategy offers an effective solution for creating blue TADF materials with high color purity. Through careful structural design and precise tuning of excited state energy levels, blue MR‐TADF materials can easily achieve a full‐width at half‐maximum (FWHM) of less than 30 nm. Nevertheless, it still faces significant challenges, such as severe aggregation‐induced quenching and efficiency roll‐off. Herein, this work overviews the recent progress of blue MR‐TADF materials and devices, and introduce representative molecular design strategies aimed at suppressing concentration quenching, enhancing reverse intersystem crossing rates, and achieving deep blue emission, which will aid future endeavors to develop more efficient, stable blue MR‐TADF materials and devices suitable for UHD display applications.
hnRNPC Functions with HuR to Regulate Alternative Splicing in an m6A‐Dependent Manner and is Essential for Meiosis
Authors: Xiong Xinxin , Feng Shenglei , Ma Xixiang , Liu Kuan , Gui Yiqian , Chen Bei , Fan Xu , Wang Fengli , Wang Xiaoli , Yuan Shuiqiao 
Published: February 2025

AbstractN6‐methyladenosine (m6A) and its reader proteins are involved in pre‐mRNA processing and play a variety of roles in numerous biological processes. However, much remains to be understood about the regulation of m6A and the function of its specific readers during meiotic processes. Here, this study shows that the potential m6A reader protein hnRNPC is essential for both male and female meiosis in mice. Germ cell‐specific knockout of Hnrnpc causes meiotic arrest at pachynema in male mice. Specifically, hnRNPC‐deficient males show abnormal meiosis initiation and defective meiotic progression, ultimately leading to meiotic arrest at the pachytene stage. Interestingly, hnRNPC‐null females show similar meiotic defects to males. Mechanistically, this study discovers that in male germ cells, hnRNPC works with HuR to directly bind and modulate alternative splicing of meiotic‐related genes (e.g., Sycp1, Brca1, and Smc5) in an m6A‐dependent manner during spermatogenesis. Collectively, these findings reveal hnRNPC as a critical factor for meiosis and contribute to a mechanistic understanding of the hnRNPC‐HuR interaction in alternative splicing of mRNAs during germ cell development.
HUWE1‐Mediated Degradation of MUTYH Facilitates DNA Damage and Mitochondrial Dysfunction to Promote Acute Kidney Injury
Authors: Yang Yunwen , Wang Peipei , Zhou Kaiqian , Zhang Wen , Liu Suwen , Ouyang Jing , Bai Mi , Ding Guixia , Huang Songming , Jia Zhanjun , Zhang Aihua 
Published: February 2025

AbstractThe role of MUTYH, a DNA repair glycosylase in the pathogenesis of acute kidney injury (AKI) is unclear. In this study, it is found that MUTYH protein levels are significantly decreased in the kidneys of cisplatin‐ or folic acid (FA)‐induced mouse AKI models and patients with AKI. MUTYH deficiency aggravates renal dysfunction and tubular injury following cisplatin and FA treatment, along with the accumulation of 7, 8‐dihydro‐8‐oxoguanine (8‐oxoG) and impairs mitochondrial function. Importantly, the overexpression of type 2 MUTYH (nuclear) significantly ameliorates cisplatin‐induced apoptosis, oxidative stress, mitochondrial dysfunction, and DNA damage in vivo and in vitro. In contrast, overexpression of type 1 MUTYH (mitochondrial) shows a marginal effect against cisplatin‐induced injury, indicating the chief role of type 2 MUTYH in antagonizing AKI. Interestingly, the results also indicate that the upregulation of the E3 ligase HUWE1 causes the ubiquitination and degradation of MUTYH in tubular epithelial cells. HUWE1 knockout or treatment with the HUWE1 inhibitor BI8622 significantly protect against cisplatin‐induced AKI. Taken together, these results suggest that the ubiquitin E3 ligase HUWE1‐mediates ubiquitination and degradation of MUTYH can aggravate DNA damage in the nucleus and mitochondria and promote AKI. Targeting the HUWE1/MUTYH pathway may be a potential strategy for AKI treatment.
A Spleen‐Targeted Tolerogenic mRNA‐LNPs Vaccine for the Treatment of Experimental Asthma
Authors: Wang Fazhan , Lou Jia , Lou Xiaohan , Wu Fang , Gao Xiaoke , Yao Xiaohan , Wan Jiajia , Duan Xixi , Deng Wenjing , Ma Lixia , Zhang Lijing , He Guangjie , Wang Ming , Ni Chen , Lei Ningjing , Qin Zhihai 
Published: February 2025

AbstractLipid nanoparticles (LNPs)‐based mRNA vaccines have witnessed their great advantages in the fight against infectious diseases. However, the pro‐inflammatory properties of mRNA‐LNPs vaccines may hinder the induction of antigen‐specific tolerogenic immune responses. Here, it is demonstrated that stearic acid‐doped LNPs co‐loaded with nucleoside‐modified mRNA and celastrol selectively target spleen, convert their adjuvanticity and promote a tolerogenic rather than immunogenic DCs phenotype. Furthermore, the tolerogenic mRNA vaccine also invokes the generation of antigen‐specific regulatory T cells (Tregs) in the spleen and migration of the induced Tregs to the lung. In a mouse model of allergic asthma, immunization with the tolerogenic mRNA vaccine significantly alleviated symptom induction, reducing eosinophilic granulocyte accumulation and mucus secretion. In conclusion, this spleen‐targeted mRNA‐LNPs vaccine platform induces tolerogenic immune responses, offering promise for the development of therapeutics against allergic asthma and other conditions requiring immune tolerance modulation.
GhLPF1 Associated Network Is Involved with Cotton Lint Percentage Regulation Revealed by the Integrative Analysis of Spatial Transcriptome
Authors: Wu Hongyu , Wang Luyao , Zhao Shengjun , Gao Mengtao , Cao Junfeng , Hao Yupeng , Yu Li , Zhao Ting , Wang Siyuan , Han Jin , Zhu Yumeng , Zhao Yongyan , Li Jie , Nie Ke , Lu Kening , Ding Linyun , Zhang Zhiyuan , Zhang Tianzhen , Guan Xueying 
Published: February 2025

AbstractCotton fibers, derived from the epidermis of the ovule, provide a sustainable natural fiber source for the textile industry. Traits related to fiber yield are predominantly determined by molecular regulations in the epidermis of the outer integument (OI) region of the cotton ovule. Here, we identify an R2R3 MYB transcription factor coding gene GhLPF1 within the QTL‐LP‐ChrA06 locus for lint percentage (LP, percentage of lint to seed cotton) through constructing the 1‐Day Post Anthesis Cotton Ovule Spatial Transcriptome Atlas. GhLPF1 is subjected as a downstream target of miR828 during fiber development. The direct downstream genes (DDGs) of GhLPF1 are biased to increased expression in GhLPF1‐CR, and are preferentially expressed in OI, so that GhLPF1 is primarily a transcriptional repressor to its DDGs. Population‐wide transcriptome analysis confirms that expression variation of GhLPF1‐DDGs is significantly biased to negative correlation with LP, among which a type I homeobox protein‐coding gene GhHB6 is further validated to be the directly downstream gene of GhLPF1. Given these data, it is demonstrated that GhLPF1 mediates a regulation network in LP as a transcriptional repressor, which makes it a valuable functional marker for fiber‐trait improvement application from QTL‐LP‐ChrA06.
LIMA1 O‐GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β‐catenin‐Regulated FASn Expression in Metabolic Dysfunction‐Associated Steatotic Liver Disease
Authors: Yang Fuji , Chen Yifei , Zheng Guojun , Gu Kefeng , Fan Lin , Li Tingfen , Zhu Ling , Yan Yongmin 
Published: February 2025

AbstractHepatic lipid deposition is a key factor in progressing metabolic dysfunction‐associated steatotic liver disease (MASLD). This study investigates the impact of the LIM domain and actin‐binding protein 1 (LIMA1) on hepatic steatotic in MASLD and explore the underlying mechanisms. Increased levels of LIMA1 is observed in both serum and serum sEV of metabolic dysfunction‐associated steatohepatitis (MASH) patients compared to healthy controls, with AUROC values of 0.76 and 0.86, respectively. Furthermore, increased LIMA1 O‐GlcNAcylation is observed in mouse models of MASLD, and steatotic hepatocytes. Mechanistic studies revealed that steatosis upregulated Host cell factor 1 (HCF1) and O‐GlcNAc transferase (OGT) expression, leading to catalyzed O‐GlcNAcylation at the T662 site of LIMA1 and subsequent inhibition of its ubiquitin‐dependent degradation. O‐GlcNAcylation of LIMA1 enhances hepatocyte lipid deposition by activating β‐catenin/FASn‐associated signaling. Additionally, compared with their AAV8‐TBG‐LIMA1‐WT counterparts, AAV8‐TBG‐LIMA1ΔT662 injection exhibited decreases in systemic insulin resistance, steatosis severity, inflammation and fibrosis in HFD‐fed and CDAHFD‐fed LIMA1 HKO (hepatocyte‐specific knockout) mice. Moreover, LTH‐sEV‐mediated delivery of LIMA1 promoted MASLD progression by promoting hepatic stellate cell (HSC) activation. The findings suggest that serum sEV LIMA1 may be a potential noninvasive biomarker and therapeutic target for individuals with MASH.