bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantum Random Number Generation using Quandela Photonic Quantum Computer
Authors: de Souza Muriel A. , Agostini Flávia P. , Tarelho Luiz Vicente G. 
Published: April 2024

Abstract

Quantum mechanics, characterized by its intrinsically probabilistic nature, offers a promising avenue for random number generation, which is essential for applications such as cryptography and computational simulations. With the recent advancements in quantum computing and simulation, numerous studies have emerged utilizing these methods for the generation of random numbers. This research delves into the exploration of random number generation utilizing the Ascella photonic quantum computer developed by Quandela, renowned for its implementation of single-photon-based qubits. Leveraging both the Ascella photonic simulator (SIM Ascella) and the quantum processing unit (QPU Ascella) within the Perceval framework, this investigation examines the capability to generate random sequences through the superposition of quantum states, generated using photons and beam splitters. The analysis includes a performance comparison between simulations and experimental tests with the quantum computer, subjecting the outcomes to the NIST SP 800-22 randomness tests. While initial simulations suggested a high degree of randomness, practical implementation revealed certain disparities attributed to factors such as decoherence, imperfections in beam splitters and single-photon sources, as well as quantum noise. This study contributes to the understanding of random number generation on quantum platforms, identifying challenges and limitations while providing strategies for future enhancements in this quantum technology.
Synthesis of lithium conducting titanium phosphates by the sol-gel process
Authors: Guillot A. , Giaume D. , Suvorova A. , Rager M. N. , de Lacaillerie J.-B. d’Espinose , Mir C. , Randrema X. , Barboux P. 
Published: April 2024

Abstract
The synthesis of solid electrolytes based on titanium and lithium phosphates was studied using the sol-gel method. Particular attention was paid to phosphate precursors, which were mixtures of phosphate mono- and di-esters prepared by solvolysis of P4O10 in isopropanol. Reaction of these precursors with titanium and lithium alkoxides yielded homogeneous gels, and after drying and thermal cleavage of the esters at 300°C, amorphous inorganic products. For the composition corresponding to the stoichiometric formula of a stable compound such as LiTi2(PO4)3, the phase crystallized as early as 550°C by nucleation from the amorphous mixture. Ionic conductivity measured at room temperature was of the order of 10-5 S.cm-1 which increased after heat treatment at higher temperatures. If the composition did not correspond to a stable thermodynamic phase, phase separation occurred, and ionic conductivity decreased between 500°C and 700°C.
Comparison Between Surgical and Non-Surgical Management of Primary Hyperparathyroidism During Pregnancy: A Systematic Review
Authors: Shezifi Eli , Gozlan Gal Shlomo , Adnan Zaina 
Published: April 2024

Abstract
Purpose
Primary hyperparathyroidism during pregnancy is an uncommon condition that may have consequences for either the mother, newborn, or both. Treatment options can be surgical or conservative. This study aimed to compare adverse outcomes associated with surgical versus non-surgical treatment to determine the favorable management option. Additionally, the study investigated the correlation between serum calcium values and complication rates.
Methods
A systematic review of retrospective studies, case series, and case reports. Biochemical parameters, interventions, and outcomes of each pregnancy were recorded. The study population comprised two groups: the non-surgical and surgical groups. Adverse outcomes were categorized as maternal, obstetric, or neonatal. Statistical analysis was conducted to compare outcomes between the study groups.
Results
The surgical and non-surgical groups consisted of 163 and 185 patients, respectively. Among the entire study population, gestational primary hyperparathyroidism (PHPT) led to maternal, obstetric, and neonatal complications in 19.5%, 32%, and 26.7% of cases, respectively. Although the mean serum calcium was higher in the surgical group (12.3 mg/dL compared with 11.1 mg/dL for the non-surgical group), no significant differences were observed in maternal outcomes and overall obstetric outcomes between the study groups. A positive correlation was observed between the mean maternal gestational calcium value and both maternal and obstetric complications, but not neonatal complications. Nonetheless, neonatal complications occurred at higher rates across all calcium values when patients were treated conservatively (p < 0.001).
Conclusions
Given the significant difference in neonatal adverse outcomes across all calcium values in the non-surgical group, along with non-inferior outcomes in the surgical group, the overall data of this study suggest that parathyroidectomy is favorable to non-surgical management even in cases of mild hypercalcemia.
First Real-Time Imaging of Bronchoscopic Lung Volume Reduction by Electrical Impedance Tomography
Authors: Torsani Vinicius , Cardoso Paulo Francisco Guerreiro , Borges João Batista , Gomes Susimeire , Moriya Henrique Takachi , Cruz Andrea Fonseca da , Santiago Roberta Ribeiro De Santis , Nagao Cristopher Kengo , Fitipaldi Mariana Fernandes , Beraldo Marcelo do Amaral , Junior Marcus Henrique Victor , Mlček Mikuláš , Pego-Fernandes Paulo Manuel , Amato Marcelo Britto Passos 
Published: April 2024

Abstract
Background
Bronchoscopic lung volume reduction (BLVR) with one-way endobronchial valves (EBV) has better outcomes when the target lobe has poor collateral ventilation, resulting in complete lobe atelectasis. High-inspired oxygen fraction (FIO2) promotes atelectasis through faster gas absorption after airway occlusion, but its application during BLVR with EBV has been poorly understood. We aimed to investigate the real-time effects of FIO2 on regional lung volumes and regional ventilation/perfusion by electrical impedance tomography (EIT) during BLVR with EBV.
Methods
Six piglets were submitted to left lower lobe occlusion by a balloon-catheter and EBV valves with FIO2 0.5 and 1.0. Regional end-expiratory lung impedances (EELI) and regional ventilation/perfusion were monitored. Local pocket pressure measurements were obtained (balloon occlusion method). One animal underwent simultaneous acquisitions of computed tomography (CT) and EIT. Regions-of-interest (ROIs) were right and left hemithoraces.
Results
Following balloon occlusion, a steep decrease in left ROI-EELI with FIO2 1.0 occurred, 3-fold greater than with 0.5 (p < 0.001). Higher FIO2 also enhanced the final volume reduction (ROI-EELI) achieved by each valve (p < 0.01). CT analysis confirmed the denser atelectasis and greater volume reduction achieved by higher FIO2 (1.0) during balloon occlusion or during valve placement. CT and pocket pressure data agreed well with EIT findings, indicating greater strain redistribution with higher FIO2.
Conclusions
EIT demonstrated in real-time a faster and more complete volume reduction in the occluded lung regions under high FIO2 (1.0), as compared to 0.5. Immediate changes in the ventilation and perfusion of ipsilateral non-target lung regions were also detected, providing better estimates of the full impact of each valve in place.
Trial registration: Not applicable.
Revealing the superior effect of using prepared nano additives for the reduction of the nitrogen oxides, carbon mono oxide, and smoke emissions of the diesel–biodiesel blend.
Authors: Elgharbawy Abdallah Sayed , Ali mohamed , Kasaby Mosaad , Sadek olfat , elwardany ahmed 
Published: April 2024

Abstract
The world is forced to look for alternative ways of energy production due to the depletion of fossil fuels and many critical pollution problems that harm the environment. The most important alternative source of energy is biodiesel which is a type of fuel synthesized from natural resources such as agriculture wastes, used cooking oil, animal fat, and algae. Biodiesel is eco-friendly fuel and has characterized over petrodiesel by its lower aromatics, sulphur, and carbon emissions. Therefore, many countries currently use diesel-biodiesel blends as a fuel for many applications. Although this blend has many advantages, it has a critical disadvantage that it emits nitrogen oxides (NOx) gases when burning higher than pure diesel. In our study, we prepared different nano additives with different concentrations (50 and 100 ppm) to be added to the diesel-biodiesel blend (B30), then investigate their effect on NOX, Carbon mono oxide (CO), and smoke emissions. The prepared nano additives were nano amorphous titanium dioxide (TiO2), nano Copper oxide (CuO), and nano zinc oxide (ZnO). All prepared additives achieved a remarkable reduction in emission compared with diesel-biodiesel (B30) blend. Nano amorphous TiO2 achieved a superior reduction in all emissions compared to pure diesel and neat B30 as it achieves the highest NOx emissions reduction by 43.46% compared to B30 blend emissions at load 2 Nm and a concentration of 100 ppm. Additionally, the same concentration achieved 35% reduction in NOx emissions compared to pure diesel emissions at the same load. For the other additives, ZnO and CuO when added to B30 achieves a considerable reduction in emissions compared to neat B30, but when compared with neat diesel the nano additives exhibited a varied emission reduction.
Yunchengibacter salinarum gen. nov., sp. nov., a novel bacterium of the family Kordiimonadaceae isolated from sediment in Yuncheng salt lake
Authors: Guo Hao-Ran , Wang Fan , Yu Hui-Ying , Wang Chuan-Xu , Wang Zhuo , Fang Bao-Zhu , Li Xin , Li Wen-Jun 
Published: April 2024

Abstract

A Gram-stain negative, aerobic, motile and rod-shaped bacterium, light yellow to yellow bacterium, designated YC-2023-2 T , was isolated from sediment sample of Yuncheng salt lake. Growth occurred at 15–45 ℃ (optimum 37 ℃), pH 6.0–9.0 (optimum pH 7.0–8.0) and with 0–8.0% NaCl (w/v, optimum 2.0%). The phylogenetic analysis based on 16S rRNA gene showed that strain YC-2023-2T belonged to the family Kordiimonadaceae. The closely related members were Gimibacter soli 6D33T (92.38%), Kordiimonas lipolytica M41T (91.88%), Eilatimonas milleporae DSM 25217T (91.88%) and Kordiimonas gwangyangensis JCM 12864T (91.84%). The genome of strain YC-2023-2T was 2957513 bp, and the genomic DNA G + C content was 63.91%. The main respiratory quinone was Q-10 and the major fatty acids (> 10%) were iso-C15:0, C16:0, C19:0 ω8c cyclo, Summed Feature 8 (C18:1 ω6c or C18:1 ω7c) and Summed Feature 9 (iso-C17:1 ω9c or C16:0 10-methyl). The major polar lipids consisted of phosphatidylethanolamine (PE), diphosphatidylglycerol (DPG), phosphatidylglycerol (PG), unidentified glycolipid (GL), unidentified lipid (L), and two unidentified aminolipids (AL). Based on the phylogenetic, phenotypic and chemotaxonomic characteristics, strain YC-2023-2T is proposed to represent a novel species of a novel genus named Yunchengibacter salinarum gen. nov., sp. nov., within the family Kordiimonadaceae. The type strain is YC-2023-2T (= GDMCC 1.4502T).
Evolutionary bet-hedging at the nanoscale
Authors: Kryuchkov Mikhail , Jobin Marc , Savitsky Vladimir , Smirnov Stanislav , Katanaev Vladimir L. 
Published: April 2024

Abstract
Evolutionary bet-hedging (EBT) is a theory describing a trade-off between the mean and the variance of fitness. It explains how in varying environments, lower-quality adaptations to a broader diversity of conditions (reduced mean fitness with low variances) can be evolutionary favored over an ideal adaptation to a specific narrow condition (high mean fitness with higher variances)1-5. Examples of EBT include strategies governing germination of desert annual plants, egg size variability of birds, metabolic switching in bacteria, and many more2,3,6. EBT at the nanoscale, however, has never been observed. Analyzing corneal nanocoatings7,8 across Coleoptera species (beetles), we here come across sexually dimorphic nanostructures garmenting eye surfaces of fireflies from the genera Lampyris and Luciola. While in Lampyris, as in other previously studied arthropods, corneal nanocoatings display dichotomy between the two competing functionalities – anti-reflectivity and anti-adhesion8,9, those of Luciola are surprisingly superb in both. Turing reaction-diffusion mechanism based on interactions of a protein Activator and a lipid Inhibitor governs assembly of corneal nanocoatings7,8; modeling predicts that the unique Luciola nanostructures can only form within a narrow set of parameters, suggesting the sensitivity of these insects’ vision to environmental conditions, such as temperature. Corroborating this prediction, the areal of Luciola is restricted to the mild Mediterranean, while that of Lampyris spreads across most of Eurasia. In a forward-engineering approach, artificial Turing nanocoatings can be produced8,10,11. We find that modifying the diffusion coefficient of the Turing Activator creates Luciola firefly-like nanocoatings whose parameter space is restricted as compared to the parental structures: they can form only in a narrowed range of temperatures. Our work thus describes the first example of EBT at the nanoscale; its translation to nanotechnology permits thermal control, through light interference and plasmon resonance, of surface nanopatterning for variety of applications.
Sacubitril/valsartan increased survival via inhibiting inflammation and myocardiofibrosis in Takotsubo-like cardiomyopathy
Authors: Kuang Jiangying , Jia Zhiyi , Chong Tou Kun , Chen Jian , Liu Kan , Cadeiras Martin , Li Zhaohua , Zhang Jing , Kong Yanru , Wang Xin , Sun Rong , Lu Qinghua , Liu Yusheng 
Published: April 2024

Abstract
Background: Takotsubo syndrome mostly manifests as stress-induced cardiomyopathy after physical or emotional stress. However, the exact pathological mechanism of TTS remains unclear, and specific therapies are still lacking. Therefore, we investigated the potential therapeutic effect and mechanism of sacubitril/valsartan (sac/val) on preventing myocarditis and fibrosis in patients with TTS. This study detected inflammatory responses, myocardial edema, fibrosis, etc., in TTS individuals and investigated whether sac/val increased the survival of TTS patients and reversed the remodeling of TTS animal hearts in vivo and investigated the effects of anti-myocardial inflammation and fibrosis in vitro.
Methods: Based on the Chinese Takotsubo syndrome (ChiTTS) registry, clinical cases were enrolled to investigate survival. Isoprenaline-induced Takotsubo-like animal models were established, and the animals were pretreated with sac/val. In addition, the effects of isoprenaline on cardiomyocyte and myocardial fibroblasts and protection from rhBNP were studied in detail.
Results: In the TTS group diagnosed with an LVEF ≤ 0.45, hyperglycemia, emotional stress and inflammation were found to be independent risk factors. Moreover, the baseline characteristics of the TTS patients, heart rate, emotional triggers, female sex (%), WBC count, IL-6 concentration, PCT, ALT, AST and TG were significantly associated with decreasing left ventricular ejection fraction. Sac/val decreased inflammation, as indicated by white blood cells and interleukin-6, in TTS patients compared with that in patients not receiving sac/val on day 30. During the follow-up, the percentage of surviving patients increased significantly in the TTS group treated with sac/val compared with the group not treated with sac/val at 30 days and 1 year. In animal models, Sac/val improved cardiac dysfunction in ISO-induced TTS-like cardiomyopathy and decreased myocardial inflammatory responses (IL-18 and Mac-3) by inhibiting the TLR4/NF-κB pathway and fibrosis through the inhibition of the TGFβ1/Smad pathway.
Conclusions: This study revealed that sac/val decreased inflammatory responses, myocardial edema, fibrosis, etc., resulting in an increase in the percentage of surviving TTS patients. Like in vivo and in vitro experiments, Sac/val exerted cardioprotective effects by decreasing the inflammatory response and reversing myocardial remodeling. Overall, these findings demonstrate the anti-inflammatory and antifibrotic effects of sac/val in individuals with TTS.
Study of Sargassum muticum impact on the surrounding algae in the Moroccan Atlantic coast
Authors: HANIF Noura 
Published: April 2024

Abstract

The study carried out in two sites of the Moroccan Atlantic coasts (El-Jadida and Lahdida) to evaluate the effect of the invasive speciesSargassum muticum(brown algae), shows that it has negative effects on the distribution of the surrounding algae. It has been noted that there is a higher abundance of this species in the El-Jadida area as it is a more polluted site than Lahdida. This promotes its rapid proliferation in this area and has negative effects on other naturally occurring species in the same area.Sargassum muticumhas very high resistance to abrupt changes in environmental parameters and deprives other species of mineral salts and light due to the lengthening of its thalli which can reach more than 2.5 meters in March in El Jadida area. It is therefore concluded that the presence of the invasive speciesSargassum muticumhas caused an imbalance in its growth media because it has physiological characteristics of resistance and rapid regeneration that allow it to proliferate at the expense of other species.
Revolutionizing Cancer Therapy: Artificial Intelligence-Controlled Nanorobots for Precise and Non-Invasive Tumor Eradication
Authors: S Subasree , R Deepa , P Soundarya , P Nidhishkumar 
Published: April 2024

Abstract
This paper presents a paradigm-shifting approach to cancer treatment, leveraging the synergistic potential of artificial intelligence (AI) and nanotechnology leading to precise and efficient tumor eradication. Cancer, a complex disease characterized by uncontrolled cellular growth and tumor formation, presents a formidable challenge to conventional therapies such as surgery, chemotherapy, and radiation therapy. These treatments often have debilitating side effects and long recovery periods, emphasizing the urgent need for innovative solutions. Our proposed solution represents a ground-breaking advancement in the field, centered around the development of nanorobots equipped with sophisticated AI algorithms. These nanorobots are carefully engineered to autonomously navigate the complex landscape of the human body, selectively identifying and removing cancerous cells while protecting healthy tissue from collateral damage. This novel therapeutic approach offers a paradigm shift from invasive interventions, reducing patient side effects and speeding recovery time. At the heart of this transformative technology lies the Nanobot prototype, which integrates sophisticated software enabling real-time detection and precise deployment of therapeutic agents tailored to the specific tumor type and location. Harnessing the power of AI, these nanorobots have unparalleled adaptability and responsiveness, ensuring optimal therapeutic outcomes while minimizing the risk of adverse effects. This innovative approach represents a significant leap forward in cancer treatment, providing a more targeted, efficient and patient-centered alternative to conventional methods. While the concept presented is currently conceptual, it serves as a visionary blueprint for the future integration of nanotechnology and AI in cancer therapy. Through collaborative efforts and continued advances in research and development, this transformative technology holds the promise of reshaping the landscape of cancer treatment, ushering in a new era of precision medicine and improving patient outcomes.
Imatinib-resistant Chronic Myeloid Leukaemia Patients' BCR-ABL1 Kinase Domain Mutations in the Eastern Indian Population
Authors: Kumar Ajeet , Tilak Vijai , Kumar Nilesh , Ali Akhtar 
Published: April 2024

Abstract
Chronic myeloid leukemia is a bone marrow cancer that spreads slowly. Platelets (thrombocytes), which aid in blood clotting, white blood cells (leukocytes), which protect the body from infection, and red blood cells (erythrocytes), which supply oxygen, are all produced by normal bone marrow. In chronic myeloid leukemia, the bone marrow produces an abnormally large amount of white blood cells. At first, these cells appear to function correctly. However, as the disease progresses, the blood and bone marrow become overpopulated with immature white blood cells known as myeloblasts, also known as blasts. Overgrowth of myeloblasts hinders the generation of other blood cells, resulting in anemia (low red blood cell count) and platelet shortage. In twelve CML patients who either lost their response or did not obtain it within the allotted timeframes, we examined the pattern of kinase domain mutations. The most frequent reason to request a mutation investigation was loss of molecular responsiveness. It was discovered that four patients had identifiable mutations. We identified four mutations: E255V, L387M, T315I, and F359S in our cohort.
Fischer-tropsch synthesis: effect of temperature and iron-cobalt ratio in Fe-Co/meso-HZSM-5 catalyst on liquid product distribution
Authors: Jimmy Jimmy , Rastini Endah Kusuma , Santoso Aman 
Published: April 2024

The Fischer-Tropsch synthesis converted hydrogen and carbon monoxide into linear hydrocarbons as liquid fuel. Iron and cobalt were used as polymerization catalyst, that impregnated on HZSM-5. The Fe-Co/HZSM-5 could be applied as bifunction catalyst which combined polymerizing synthesis gas and long chain hydrocarbon cracking for making biofuel. The objective of this study is observing the effect of temperature and composition of iron and cobalt combination, supported by HSZM-5 (Fe-Co/HZSM-5) catalyst on fuel product composition. The results obtained from this study would be used to find optimum condition for various iron and cobalt ratio in the catalyst. The mesoHZSM-5 was prepared from ammonium ZSM-5 over calcination, desilication, and dispersion. The mixed solution consisted of Co(NO3)2.6H2O and Fe(NO3)3.9H2O were used as precursor for incipient wetness impregnation on HZSM-5. The catalyst performance was observed in a continuous fixed bed reactor using Fe-Co/meso-HZSM-5 catalyst with synthesis gas at various composition iron and cobalt ratio (10–40 % wt. Fe in Co), various temperature (225–275 °C) at 20 bars. All catalysts were reduced in situ in the reactor. The 10Fe-90Co/mesoHZSM-5 catalyst was more suitable for FTS at 250 °C with alkane (20.49 %) as the main product and alcohol as the by-product (79.51 %). The others catalysts composition of 20–40 % Fe (by weight) in Fe-Co were more suitable for FTS at 225–250°C because under these conditions, alkanes as the main product were obtained in relatively higher compositions compared to other compounds. The mechanism of paraffins, olefins, aldehydes and alcohols formation in this FTS reaction followed the hydrogen assisted CO dissociation with CO-insertion mechanism