bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carcinoma of the esophagus
Authors: Rambo V. Birch , O'Brien Paul H. , Miller M. Clinton , Stroud Martha Rohrer , Parker Edward F. 
Published: February 2007

AbstractLife tables were computed from the Tumor Registry at the Medical University of South Carolina on 486 patients with histologically proven squamous cell carcinoma of the esophagus. The 5‐yr follow‐up was available in only 394 patients, or 81% of the total sample. For purposes of comparison with published literature, the traditional crude 5‐yr survival percentages in the life‐table analyses figures are presented. The life‐table calculation utilizes all follow‐up information available, in that patients observed for less than 5 yr still may contribute to the estimate of the true 5‐yr survival rate in contrast to the past when all patients lost to follow‐up were presumed to have died. In this method, patients not observed for the full time of the study are assumed to have had the same risk of dying as patients followed to the end of the fifth year experienced in their fifth‐year analyses. The group with the most favorable prognosis in this series was that receiving preoperative irradiation. This operation. They were given 4,500 rads of supervoltage X ray over a period of 3 weeks prior to operation. The differences in surgical or radiation techniques employed by various reporters make comparative data difficult, if not impossible, to evaluate. Supervoltage irradiation has proved itself in some hands equal to surgery. A randomized prospective study would seem appropriate to conclude the best means of managing epidermoid carcinoma of the esophagus.
Further studies on a transmissible entity in relation to the control of cancer in mice
Authors: Strong Leonell C. , Matsunaga Henry 
Published: February 2007

AbstractTumor‐bearing mice of the C3H/ST inbreds were used in this investigation. Of the 598 mice, 290 were controls, 248 received injections of 5‐methyl cytidine dissolved in physiological salt solution, and 60 received injections of three nucleosides — adenosine, 6‐methyl adenosine, and 5‐methyl cytidine ‐ also dissolved in physiological salt solution. The mice were divided into 6 groups based upon the number of generations of descent from a mouse injected with an alcohol‐soluble liver extract. The criterion of tumor growth is the average increment of growth at the 20th observation period in the 7th week (3 per week). There is a cumulative inhibition of tumor growth, compared with controls, when 5‐methyl cytidine is added to the effect of a transmissible entity which occurs in the lineal descendants of a tumor‐bearing mouse injected with an alcohol‐soluble liver extract and when the combination of three nucleosides in the same ratio of molar concentrations as in the liver extract is added to the effect of the transmissible entity.
A predictive test for the selection of cancer chemotherapeutic agents for the treatment of human cancer
Authors: Wright Jane C. , Walker Dorothy 
Published: February 2007

AbstractThe use of animals for the screening of chemotherapeutic agents effective against cancer is not always satisfactory. In addition to the problems of cost, space, and care, the results obtained by animal screening do not always parallel those obtained by the clinical use of the agents.With the advent of more refined in vitro technics which can be applied directly to the patient's own tumor tissue, additional information may permit a more critical evaluation of the laboratory findings. The critical index of sensitivity probably lies in the combined evaluation of biochemical analysis and observed morphological damage.From this investigation it would appear that tissue culture of human tumors may serve as a valuable adjunctive method for the screening of chemicals in order to find drugs valuable in the treatment of cancer in man and to serve as a method in the selection of the most effective therapeutic agent for a given tumor in a given patient.
Vagotomy—a prospective, randomized study
Authors: Bombeck C. T. , Condon R. E. , Nyhus L. M. 
Published: February 2007

AbstractThis is a report of a prospective randomized study of 3 operations for duodenal ulcer; parietal‐cell vagotomy alone (without drainage), selective vagotomy with antrectomy, and truncal vagotomy with antrectomy. AH patients in the study have been followed for a minimum of 1 yr and despite the small number of patients (total 23 in the report), there has been a statistically significant return of gastric secretory activity to preoperative levels in the parietal cell vagotomy group, while both other groups maintained decreased acid secretion at the 1‐yr period. To date there has been one recurrent ulcer and one other suspected ulcer in the parietal cell vagotomy group, while both other groups have no ulcer recurrence even though morbidity has been higher (bile reflux gastritis, and so forth). This preliminary evaluation suggests strongly that extreme caution be used in applying parietal‐cell vagotomy alone as a definitive for duodenal ulcer, but because of the small number of patients involved no conclusions can be drawn at this time.
Phase I studies of porfiromycin (NSC—56410) in solid tumors
Authors: Grage Theodor B. , Weiss Arthur J. , Wilson William , Reynolds Vernon 
Published: February 2007

AbstractPorfiromycin was given to a group of patients with a variety of solid tumors. Of 114 patients admitted to the study, 103 yielded evaluable data. The following dosage schedules were used to determine the toxicity of porfiromycin when given in multiple doses by intravenous injection: 0.2 mg/kg × 5 days, 0.3 mg/kg × 5 days, 0.35 mg/kg × 5 days, 0.4 mg/kg × 5 days, 0.24 mg/kg × 10 days and 0.6 mg/kg weekly. Toxic effects noted were mainly leukopenia, thrombocytopenia, and, when injected paravenously, local tissue necrosis. Biological effects were noted at all dosage levels and were more severe at the higher dosages. The data suggest that profiromycin administered intravenously at a dose of 0.35 mg/kg daily for 5 days results in moderate hermatological toxicity and clinical evaluation in a Phase II study at this dosage level is indicated.
Experience in the surgical treatment of diseases of the thyroid gland
Authors: Molina J. E. , Stehling L. C. , Zauder H. L. , Aust J. B. , Cruz A. B. 
Published: February 2007

AbstractOver a 7‐yr period from January 1967 to January 1974, 141 patients underwent thyroid surgery for various pathology at the Bexar County Hospital‐University of Texas Medical School at San Antonio. Of these, 113 patients underwent subtotal thyroidectomy for benign diseases, including 28 of thyrotoxic patients who underwent subtotal thyroidectomy as definitive treatment. In this group of patients special interest and emphasis was placed in the preoperative and intraoperative management of the difficult and complicated hyperthyroid patient. Preoperative treatment was accomplished by the utilization of multiple drug combinations—including antithyroid drugs, adrenergic blocking agents, and iodine—which resulted in a significant decrease in preparation time for surgery. Furthermore, this short intensive preoperative management of complicated hyperthyroid patients allowed satisfactory correction of their problems with little or no morbidity which otherwise would have been extremely difficult if not impossible to resolve.At operation, 28 patients were diagnosed to have malignant disease; 23 underwent total thyroidectomy and the other 5 had subtotal thyroidectomy. In addition to total or subtotal thyroidectomy, 23 patients had either classical or modified radical neck dissection including 9 patients who had bilateral neck dissection. The various surgical techniques utilized, the rationale for rapid preoperative preparation of complicated hyperthyroid patients, morbidity, and long‐term follow‐up are discussed.
Medullary thyroid carcinoma
Authors: Raynor A. Clark , Sowden David 
Published: February 2007

AbstractMedullary thyroid carcinoma is an infrequent and unusual malignancy. Since its description 15 years ago, many new features have developed. Many biologically active compounds which are directly related to the different symptoms of the disease have been recovered from the tumors. A familial incidence is noted, and there is an increased association with other tumors and their behavior. The cell of origin is the parafollicular cell, which secretes calcitonin and is responsible for the unusual behavior of medullary thyroid carcinoma. Treatment is primarily surgical. Four cases are presented and the syndrome reviewed.
Treatment of chronic lymphocytic leukemia and lymphosarcoma with a new chlorambucil ester of prednisolone (Leo 1031) (NSC‐134087)
Authors: Aungst C. William , Mittelman Arnold , Murphy Gerald P. 
Published: February 2007

AbstractA new chlorambucil ester of prednisolone (LEO 1031) has been evaluated in patients with advanced lymphocytic lymphosarcoma and chronic lymphocytic leukemia. All 11 patients had been previously treated with radiotherapy and/or combination chemotherapy. Three complete remissions and one partial remission were seen in 4/7 lymphocytic lymphosarcoma patients treated with LEO 1031. In the chronic lymphocytic leukemia group, 3/4 have had benefit. This new drug is considered worthy of further trial.
Migration inhibition test in lung cancer patients
Authors: Marabella Patrick C. , Elias Linda L. , Takita Hiroshi , Minowada Jun 
Published: February 2007

AbstractTwenty patients with primary carcinoma of the lung were tested with migration inhibition test, using extract of cultured lung carcinoma of large cell type, Eight of 10 patients with localized disease had positive inhibition, while all 10 of the patients with disseminated disease had negative inhibition (x2, p < 0.005).Two cases of large cell carcinoma (localized) showed extremely positive inhibition which may suggest the presence of cell type specific lung carcinoma antigen.
Fluorescence microscopy in tumors of central nervous system: A method of recognizing malignancy with acridine orange
Authors: Banerjee Timir , Yashon David 
Published: February 2007

AbstractTumors of the central nervous system were stained with acridine orange. Photographs were taken during observation through ultraviolet light. Cellular detail was not recognizable but malignant tumors fluoresced more than benign tumors.
Ovarian cancer presenting as umbilical hernia
Authors: Millar Roger C. , Geelhoed Glenn W. , Ketcham Alfred S. 
Published: February 2007

AbstractSix patients are reported whose presenting symptom was umbilical herniation. Upon exploration of the umbilicus with the intent to repair the hernia, ovarian cancer and malignant ascites were encountered in each individual.Cancer at the umbilicus, both metastatic and primary, is briefly discussed. The appearance of an acquired umbilical hernia in an otherwise asymptomatic patient should raise the suspicion of intraabdominal malignancy.
Oxygen consumption by acrylamide polymerization: A method for rapid screening of anticancer agents
Authors: Tapper David , Johnson Richard , Folkman Judah 
Published: February 2007

AbstractWe have developed a rapid and sensitive method to measure oxygen consumption of tumor cells by acrylamide polymerization. This method could be used as an in vitro screen for potential chemotherapeutic‐agents. Previous techniques have lacked either the sensitivity or the speed required for use as an effective clinical tool. This method was modified from a technique previously developed in our laboratory for measuring oxygen in blood. Standard anticancer agents were tested against Walker 256 ascites tumor. Ascites was harvested from 20 rats on each of 50 days, incubated briefly with drugs, and acrylamide polymerization time was measured hourly. Individual controls were established for each drug‐treated group, and oxygen uptake measured after one hour of incubation. Actinomycin, cyclohexamide, and cytosine arabinoside inhibited tumor cell oxygen consumption by 80%, 40%, and 30%, respectively. These results correlated with the known in vivo effects of these drugs on Walker carcinosarcoma. Therefore, this sensitive method could potentially be used directly on tumor cells removed from biopsy material so that the testing of anticancer drugs could be completed on the day of biopsy.
Chemotherapy of a murine neuroblastoma model
Authors: Murphy Gerald P. , Williams Phyllis , Keogh Brian 
Published: February 2007

AbstractThe C1300 murine neuroblastoma model can be readily maintained by serial passage in A/J mice. Characteristics of the tumor, such as weight of the primary lesion, days of survival after tumor inoculation, or the number of metastatic foci at death, are relatively reproducible and permit experimental evaluation of various modes of treatment, including chemotherapy, that are not possible in man. In the present study, single‐dose adriamycin chemotherapy was of significant benefit Multiple dose treatment was too toxic and lethal. Cytosine arabinoside in various doses was without detectable merit. These results, from an animal model, are of benefit in evaluating further possible drug combinations in ongoing clinical trials seeking to improve the results from chemotherapy in children with advanced neuroblastoma.
An inverse dose response of 5‐methyl cytidine on multiple primary spontaneous tumors and their regressions in mice
Authors: Strong Leonell C. , Matsunaga Henry 
Published: February 2007

AbstractTen series mice of C3H/ST inbreds with spontaneous tumors have received 5‐methyl cytidine (total 500 mice). Graded single doses of (1) 3.86, (2) 2.57, (3) 2.06, (4) 1.54, (5) 1.03, (6) 1.54, (7) 1.03, (8) 0.51, (9) 0.26, and (10) 0.13 mg/injection (three times weekly) were used. In series 1–5 the 5‐methyl cytidine was dissolved in distilled water, and in series 6–10, the nucleoside was dissolved in physiological salt solution. In doses administered, series 4–5 overlapped with series 6–7.The number of mice that showed a regression of tumor increased in the successive series (48%–63% in series 1–5 and 25%–73% in series 6–10). As the number of mice with regressing tumors increased, the percentage of mice showing multiple primary tumors also increased. The administration of the nucleoside in physiological salt solution altered the inhibitory effect of 5‐methyl cytidine on spontaneous tumors. For example, in physiological salt solution the 0.51 mg/injection gave as much inhibitory action as 1.03 mg/injection in distilled water. An inverse dose response is thus indicated between the amount of 5‐methyl cytidine injected and the inhibition of spontaneous tumors in mice (percentage of regression and number of multiple primary spontaneous tumors are the criteria of inhibition considered).
Cystadenoma and cystadenocarcinoma of the pancreas
Authors: Barbee Charles L. , Demello Fernando B. , Grage Theodor B. 
Published: February 2007

AbstractCystadenoma and cystadenocarcinoma comprise the majority of the true neoplastic cysts of the pancreas. Five cystadenomas and two cystadenocarcinomas of the pancreas were found in a review of the clinical records of the University of Minnesota Hospitals and the Minneapolis Veterans Administration Hospital. The report of these cases serves to review the clinical and pathological features of these neoplasms. These rare neoplastic cysts occur predominantly in women and are not associated with a history of trauma, alcoholism, or pancreatitis. They produce symptoms by compression of neighboring organs and are slow growing, often attaining large size. With complete excision the results of surgical treatment are usually good.
Desmoid tumor associated with cystosarcoma phyllodes of the breast
Authors: Abadir Rushdy 
Published: February 2007

AbstractA case of desmoid tumor of 17 years' duration associated with cystosarcoma phyllodes of 17 months' duration is presented. Good initial response to radiation therapy of the desmoid tumor was shown. Poor response of cystosarcoma phyllodes to radiation therapy was noted. A comparison between the similarities and differences of the two tumors is presented.
Impaired cytotoxicity of lymphocytes from patients with cancer
Authors: Suciu‐Foca Nicole , Buda Joseph A. , Herter Frederic , Molinaro Anthony , Broell John , Reemtsma Keith 
Published: February 2007

AbstractWe have investigated the ability of peripheral blood lymphocytes from 57 cancer patients and from 54 normal controls to exert cytotoxic activity in vitro on allogeneic target cells by using a residual tritiated proline assay. Phytohemagglutin was added to the cultures for potentiating the reaction. The cytotoxic potential of lymphocytes from cancer patients was significantly lower than that of healthy controls. Increased survival of target cells was found in numerous reactions with patients' lymphocytes, probably reflecting a “feeder” effect. The source of plasma used for testing, i.e., autologous or pooled normal homologous plasma, did not affect the strength of cytotoxicity reactions displayed by lymphocytes from either normal or cancer patients. A lower reactivity was generally seen in patients with metastatic disease than in patients with no evidence of distant spread.
Splenectomy or radiation and splenectomy for hypersplenism in lymphosarcoma
Authors: Shukla Satish K. , Evans James T. , Mittelman Arnold 
Published: February 2007

AbstractThis is a retrospective study of 14 patients with lymphosarcoma with hypersplenism. Eight patients received radiation to the spleen followed by splenectomy for recurrence of hypersplenism. Six patients underwent primary splenectomy for hypersplenism.Radiation decreases the size of the spleen but recurrence of hypersplenism is seen in an average of 8 mo. Splenectomy in these cases improves the hematological picture. Average postsplenectomy survival is 27.6 mo.Splenectomy alone in hypersplenism also improves the hematological picture. Postsplenectomy survival in this group is 13 mo.One case of primary lymphosarcoma of the spleen is reported.
Reticulum cell sarcoma of the cecum and macroglobulinemia: A case report
Authors: Levy Mitchell , Stone Alex M. , Platt Norbert 
Published: February 2007

AbstractA case report is presented of an 81‐yr old male who developed a reticulum cell sarcoma of the cecum while on immunosuppressive therapy for 13 yr for a primary diagnosis of macroglobulinemia. The considerable overlap between immunoproliferative disorders and the increased incidence of malignancies in patients receiving immunosuppressive therapy are discussed.
Analysis of variance and covariance for colorectal adenocarcinomas in man as a logical prelude to “staging”
Authors: Watson Francis R. , Spratt John S. , Leduc Richard J. 
Published: February 2007

AbstractThis study reports initial experience at the Ellis Fischel State Cancer Hospital (EFSCH), Columbia, Missouri, with the analysis of variance and covariance as applied to the ability to predict the lethality associated with colorectat neoplasms as influenced by tumor, host, and treatment variables considered individually and as multivariate clusters.The application of the methods to the clinical setting is based on the fact that each patient has one survival time. However, in the mathematical sense, each patient is composed of many different variables interacting simultaneously in highly complex ways to determine this uniqueness.The feasibility of determining the prognostic score or weight of many variables is illustrated. The combinatory effect of these scores can provide prognostic scores for clusters of variables providing a tool of much greater specificity than is provided by traditional staging systems such as the TNM.
Tritiated thymidine labeling index of benign and malignant human breast epithelium
Authors: Meyer John S. , Bauer Walter C. 
Published: February 2007

Abstract38 specimens of benign breast tissue from young women and 92 primary breast carcinomas were evaluated for tritiated thymidine ([3H] TdR) labeling index (TLI) by in vitro pulse labeling. The TLI on non‐neoplastic, terminal breast ducts was significantly higher during the latter half than during the first half of the menstrual cycle (P < 0.001), and a geometric mean TLI of 1.5 during the latter half of the cycle is consistent with approximately 47% turnover of these cells during the menstrual cycle. Ducts of fibroadenomas showed similar menstrual variation TLI. The range of TLI observed in the carcinomas was 0.04‐18.6, arithmetic mean 3.7, geometric mean 2.1. The TLI of carcinomas was not significantly correlated with size of the tumor, but tended to be higher in women less than 50 yr old than in women older than 50 yr (P < 0.05), and in the presence of two or more metastatic axillary lymph nodes than when fewer than two nodes were involved (P < 0.02).
Immunocompetence and spontaneous regression of metastatic renal cell carcinoma
Authors: Boasberg Peter D. , Eilber Frederick R. , Morton Donald L. 
Published: February 2007

AbstractSpontaneous remission of pulmonary metastases from renal cell carcinoma was correlated with a positive response to dinitrochlorobenzene (DNCB). When first seen, the patient was DNCB negative and a chest radiograph showed nodular densities in the right lung and left midlung. Six months after sensitization, the patient had a positive response to DNCB and no evidence of lung metastases. Three mo later, the patient developed brain metastases although X‐ray examination showed no pulmonary nodules. A diminished response to DNCB was noted over the next several months and chest X ray verified the return of pulmonary metastases.
Possible factors in remote metastases in female breast cancer
Authors: Shanta V. , Krishnamurthi S. 
Published: February 2007

AbstractThe association of metastases (M) with age of patient, stage of disease, the gross and microscopic characteristics of the primary tumor, its physical location, the postradiational status of the breast, the extent and level of histological nodal involvement, the type of surgery practiced, and the host's biological environment are analysed.The authors conclude that the critical factor in systemic dissemination in female breast cancer is the extent and level of metastatic nodal involvement. Though the association between stage of disease, character of tumor (T), and histology are significant, the crucial factor seems to be the nodal involvement. Systemic metastases are significantly higher in inner quadrant tumors. Possible methods of circumventing this dissemination are discussed.
Carcinoma distantly metastatic at diagnosis: Improvement in survival, 1945‐1974
Authors: Holmes Frederick F. , Olson Suzanne , Lash Chip , Henry J. Mitchell 
Published: February 2007

AbstractSurvival rates for 3,842 Kansas and Missouri patients with carcinoma metastatic at diagnosis who were registered between the years 1945 and 1974 were examined. While there was no improvement in survival comparing the 1945‐1954 and 1955‐1964 decades, there was significant recent improvement in survival when the 1,805 patients diagnosed from 1945 to 1964 were compared to 2,037 patients diagnosed from 1965 to 1974. It was concluded that even in this particularly unfavorable presentation of cancer, there has been definite improvement in survival in the past decade.
Diffusion chamber hematopoiesis in marrow and spleen cells from mice infected with rauscher leukemia virus (RLV‐A)
Authors: Koltun Leonard A. , Lobue Joseph , Fredrickson Torgny N. , Gordon Albert S. 
Published: February 2007

AbstractPreleukemic and terminal phase marrow cells from RLV‐A‐infected mice placed within diffusion chambers and implanted into normal mice, maintained elevated levels of both erythroid and myeloid precursor cells, whereas normal control marrow cells grown within diffusion chambers in normal hosts did not. Splenic tissue from preleukemic and terminal mice when placed as a cellular suspension into diffusion chambers and implanted into normal recipients also maintained high erythroblast numbers. However, while some transient growth of myeloid precursor elements occurred in preleukemic spleen cultures, terminal spleen cultures displayed essentially no granulocytic precursor cell growth. In control spleen cultures, erythropoiesis and granulocytic precursor cell numbers were reduced to non‐detectable levels after 4 days of culture.