bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANÁLISE ACERCA DAS MANIFESTAÇÕES DA NEFROTOXICIDADE POR AMINOGLICOSÍDEOS
Authors: Santos Pedro Arturo Bismara Carneiro , Freire Rodrigo José Bumussa , Giulianis Marco Antonio Montagner , Sabino Milla Proto de Mattos , Cabral Nailda Muniz Medeiros Domiciano , Moreira Edson Lemos , Ferreira Thauana Santos , Macedo Barbara Louiza Gomes de , Reis Felipe Hubechara do Rego , Timóteo Tamie Oliveira , Zem Bruna Suelen de Souza , Lacerda Wenddy de Lima Cavalcanti , Bueno Giulia Zoccoli , Rodrigues Henrique Gomes , Gonzalez Alejandra Susse Justiz , Martins Helman Fernando Paraguay , Menezes Filho Gilberto Vilaça de , Xavier Luigi Miguek Brenha , Laranja Mariana Menezes , Nóbrega Neto José Moreira da , Macedo Bruna Souza 
Published: April 2024

Introdução: Este artigo de revisão aborda as manifestações da nefrotoxicidade induzida por aminoglicosídeos, destacando-se como uma contribuição para a compreensão e manejo desta condição clínica relevante. Definimos a nefrotoxicidade e sua importância dentro do contexto do tratamento com aminoglicosídeos. Objetivo: Analisar as implicações da toxicidade renal pelos aminoglicosídeos e as manifestações clínicas que acometem o paciente. Metodologia: Essa revisão integrativa da literatura, foi realizada por busca em base de dados de artigos que correspondessem ao tema proposto. Incluiu-se avaliação dos artigos elegíveis na íntegra, excluindo aqueles que não se enquadram nos objetivos do estudo, teses e dissertações, sem contabilizar duplicatas. Resultados e Discussão: Enfatiza a injúria renal aguda não oligúrica, disfunção tubular distal e anormalidades eletrolíticas como manifestações principais, destacando a importância da detecção precoce e do manejo adequado destas condições para prevenir a progressão para formas mais graves de lesão renal. Conclusão: Apesar dos desafios impostos pela nefrotoxicidade aminoglicosídica, uma compreensão aprofundada dos seus mecanismos e manifestações pode contribuir significativamente para a segurança e eficácia do uso desses antibióticos, minimizando os riscos associados e melhorando os desfechos clínicos para os pacientes.
Radiomica en pacientes con adenocarcinoma y carcinoma escamoso en Tomografia computada de Pulmon con correlacion histopatológica
Authors: Noguera Eduardo , Tisera Castanie Candelaria , Orozco Santiago 
Published: April 2024

Objetivo Investigar en la imagen tomografica del cáncer de pulmón la asociación entre las texturas radiómicas (TR) y los subtipos histopatológico (adenocarcinoma y carcinoma escamoso). Materiales y métodos: Estudio retrospectivo y observacional, realizado en 43 pacientes , 29 (67%) hombres y 14 (33%) mujeres ,entre 45 y 83 años ( mediana 63 ± 16años) con cáncer de pulmón. Usando el programa Slicer 5.3.0- Pyradiomic se extrajeron del volumen tumoral tomografico segmentado , 115 TR , para analisis estadístico y aprendizaje automatico con el programa WEKA donde las TR fueron ; (a) normalizadas, los estudios balancedos con SMOTE y divididos en entrenamiento y prueba, para ser clasificados con Autoweka configurado con el árbol DecisionStumps. Resultados; El diagnóstico histopatológico fue ; adenocarcinoma en 36/43 (84%) , carcinoma escamoso 7/43 (16%) . Treinta y tres tumores (78%) tenian biomarcadores de mutaciones genéticas, positivas en 18 (54%) y negativas en 15(45%). Once TR mostraron diferencias significativas en las medias entre el adenocarcinoma vs carcinoma escamoso. Analisis univariado mostró que TR , GLCMAutocorrelation con AUC del 82%, predicen la histopatologia del adenocarcinoma vs carcinoma escamosos , y con AutoWeka y el clasificador DecisionStumps , las TR , GLSZMGrayLevelNonUniformity , HightGrayLevelZoneEmphasis, LargeAreaHightGrayLevelEmphasis , lo hacen con una precision del 90% , sensibilidad de 100% vs 78% , con coeficiente de correlacion Mathews del 0.82 , y AUC mayor al 80%, para ambos grupos. Conclusiones: Radiomica es una herramienta prometedora para la predicción no invasiva de subtipos histológicos de cáncer de pulmón en la imagen tomografica de pulmón.
Implementation of Problem Based Learning (PBL) Models to Improve Student Physics Learning Outcomes
Authors: Nainggolan Rini Siti Suleha 
Published: April 2024

This study aims to determine the increase in student physics learning outcomes, teacher and student activities, the teacher's ability to manage learning, as well as student responses to the application of the Problem Based Learning (PBL) models in Newton's Law material during the learning process. This type of research is Classroom Action Research (CAR). The subjects in this study were class X students of one of senior high school in Pargodungan for the 2020/2021 academic year with a total of 29 students. Data collection instruments that researchers use in research are observation sheets, tests and questionnaires where the three data are analyzed with descriptive statistics. The results showed that (1) the percentage of individual completeness as a whole increased from cycle I to cycle III, namely 69%, 80%, and 94%, and the percentage of classical completeness as a whole also increased, namely 40%, 70%, and 80%; (2) there is an increase in teacher and student activity during the learning process; (3) there was an increase in the teacher's skills in managing learning from the fairly good category with an average of 2.59 to good with an average of 3.4; (4) student responses tended to be positive where 100% of students expressed pleasure in learning using this Constructivism-Problem Based Learning model. From this study it can be concluded that the application of the Problem Based Learning (PBL) Learning Model can improve the physics learning outcomes on Newton’s Law topic.
MENGUNGKAP KENDALA PENERAPAN SAK EMKM PADA UMKM DI KECAMATAN SANDUBAYA
Authors: Miftahatul Khairani Ulfa  , Halpiah Halpiah , Hery Astika Putra  
Published: April 2024

This research is entitled “Uncover The Obstacles In Implementing SAK EMKM At UMKM In Sandubaya Sub-District”. The purpose of this research is to find out obstacles faced by UMKM actors in Sandubaya sub-district in implementing SAK EMKM. This research is a qualitative research with a narrative approach. The type of this research is used field research. Key informants in this research were the owners of UMKM in Sandubaya sub-district, especially UMKM of Bread UMKM Babakan Village, Tofu UMKM Abiantubuh Village, and Fried Onion UMKM Mandalika Village which is the focus of research. The results of this research indicate that some of the obstacles that are the cause of not implementing SAK EMKM at UMKM in Sandubaya sub-district are, lack of accounting knowledge of UMKM actors, improper perception regarding the recording of financial statements, there is no socialization about SAK EMKM to UMKM actors, absence competent of human resources in accounting and management, lack of educational background, average age fourty years old and above, and also the absence of regulations from the government,as well as to avoid taxes.
Presentación - Leituras e releituras da violência nas literaturas de língua francesa - Lecturas y relecturas de la violencia en las literaturas en lengua francesa
Authors: Ferreri Natalia Lorena , Aiello Francisco 
Published: April 2024

A Revista REVELL convidou pesquisadores a enviar artigos, ensaios, entrevistas e resenhas para sua edição v.1, n.31 - 2022, cujo tema do dossiê é Leituras e Releituras da violência nas Literaturas de Língua Francesa - Lecturas y relecturas de la violencia en las literaturas en lengua francesa. O tema da violência em suas dimensões simbólica, física, institucional, psicológica e estrutural deve ser abordado em obras literárias escritas em língua francesa. A perspectiva como leitura e releitura da violência propõe que o âmbito das abordagens indague sobre as obras contemporâneas, bem como revisite a partir de referenciais teóricos atuais produções consagradas ou de outros períodos literários.
As reflexões teóricas sobre a violência na França estendem-se desde o período denominado “la Terreur” - cuja representação tanto mecânica quanto moderna foi a guilhotina - momento entendido como anatomopolítica, passando pela biopolítica, pelos terrorismos fundamentalistas (Maalouf), pelos terrorismos de Estado, até os dias atuais. dia à microviolência (Foucault) do cotidiano tanto em suas manifestações de controle espacial, discursivo e de vigilância, quanto no governo das emoções. Diante de perspectivas enviesadas que reconhecem a violência em suas manifestações mais ostensivas, nosso interesse por este dossiê busca reunir obras que contemplem a natureza fundadora da violência, conforme explica o filósofo francês Paul Ricœur (2000), embora reconhecendo sua capilaridade, que supõe - de acordo com os estudos da antropóloga argentina Rita Segato - sua penetração em múltiplas camadas sociais. É a partir dessas discussões teóricas que este dossiê busca os objetivos principais de identificar as elaborações retóricas e estéticas da violência na literatura de língua francesa, atualizar leituras de obras de períodos anteriores, construir um panorama sobre a temática da violência, formando uma abordagem teórica do corpo que aborda este problema multidimensional.
Marcas de Resistência na Crônica "Luto da Família Silva", de Rubem Braga
Authors: Pompeu Brasil Francisca Patrícia 
Published: April 2024

Alfredo Bosi (2002) afirma, em seu texto “Narrativa e Resistência”, que a ideia de resistência se conjuga à narrativa a partir de duas formas de realização: como tema e como processo inerente à escrita. Cronista por excelência, Rubem Braga pode ser citado como um exemplo de escritor que realiza, em suas crônicas, essas duas formas de resistência: na forma, através do lirismo e da voz do narrador de tradição; nos temas abordados, os quais levantam questionamentos e reflexões sobre sociedade e política. Com o intuito de mostrar como a resistência se faz presente na obra de Braga, optamos por trabalhar a crônica “Luto da família Silva”, produzida em 1935 a partir de uma notícia de jornal. Nessa crônica, Braga questiona, através da ironia e do humor, a luta de classes, a condição do excluído e a invisibilidade social dos inúmeros “Joões da Silva”. Em nosso trabalho, consideramos as marcas de resistência como tema e como forma imanente ao texto. Para isso, fundamentamos nossa pesquisa na obra Literatura e Resistência de Alfredo Bosi. Também compartilhamos das ideias apresentadas por Walter Benjamin (1994), em seu texto “O narrador: considerações sobre a obra de Nikolai Leskov”. Além dos textos citados, foram consultados, como fontes de pesquisa, “La Forma Inicial”, de Ricardo Piglia (2015); e os ensaios sobre as crônicas de Rubem Braga, “Braga de novo por aqui” e “Fragmentos sobre a crônica”, de Davi Arrigucci (1987).
Caliban en el pensamiento de Roberto Fernández Retamar
Authors: Onofre Vilchis Carlos I. 
Published: April 2024

Distintas interpretaciones en literatura, historia y filosofía han problematizado el personaje y la categoría de Caliban. Perspectivas contemporáneas: Eagleton (2001), Frey (2000), Kirk (2006), Rebaza-Soraluz (2004) —sólo por mencionar algunos casos— enfrentan la cuestión de la resignificación simbólica de tal concepto. La finalidad del presente artículo es responder la siguiente interrogante: ¿ A partir de la formulación y el planteamiento que Fernández Retamar hace de lo posoccidental (como una ideología que permite comprender y superar a Occidente, es decir, como aquello con lo que América Latina, o Caliban, se ha estado “confrontando”) se puede llevar a cabo una reinterpretación del símbolo de Caliban, ahora con características posoccidentales? Con el análisis de dicha cuestión, se busca seguir adecuadamente la polémica clásica y contemporánea que al respecto, en literatura, historia y filosofía se encuentra disponible.
USO DOS INSTRUMENTOS CONSTITUCIONAIS DA DEMOCRACIA DIRETA
Authors: ALENCAR JOAQUIM CARLOS KLEIN DE 
Published: April 2024

Este artigo analisa a atual conjuntura da democracia representativa no Brasil, com foco na forma de exercício do poder político e suas premissas básicas, e mais especificamente investiga o uso/eficácia/concretização dos instrumentos postos à disposição da/o cidadã/o para a participação direta no debate político, especialmente o plebiscito e o referendo, e ainda se há viabilidade na melhoria desses mecanismos, ou, na concretização de propostas tendentes a aperfeiçoar o aparelho democrático. Utiliza-se o método dedutivo, e a pesquisa do tipo exploratória, que envolvem estudos bibliográficos, e, para tanto, dialogamos com Bobbio (2006b), Arendt (2007), Canotilho (2002), Santos (2000/2002), Barroso (2006), Dallari (2010), dentre outros/as. O objetivo geral do artigo é, portanto, analisar e compreender criticamente o complexo teórico-normativo respectivo que compõe a atual a estrutura política democrática brasileira, cujo paradigma é constitucional. Especificamente, o texto objetiva refletir sobre a participação popular direta na concretização do regime democrático, Investigar os instrumentos postos à disposição do povo na consecução dos fins democráticos e se tais mecanismos são eficazes quanto ao uso, e, finalmente sugerir estratégias para o aperfeiçoamento da democracia brasileira, especificamente quanto ao uso do plebiscito e do referendo. Defendemos, conclusivamente, que a participação popular precisa avançar no Brasil, como uma das formas que entendemos urgente e necessária para o aperfeiçoamento do Estado Democrático, com a utilização dos instrumentos da democracia direta expressos da Constituição – Plebiscito e Referendo -, como necessária e obrigatória quando o tema debatido no Congresso Nacional for referente aos Direitos e Garantias Fundamentais, eis que o destinatário dos Direitos precisa, necessariamente, se manifestar, sob pena de verdadeira fraude ao sistema garantias instituído pelo Constituinte Originário.
Methodology for Robust Revalidation of the CHERG VASA Tool to Investigate Under-5 Deaths in Karachi Slums: A Mixed Methods Approach
Authors: Siddiqui Muhammad Bilal 
Published: April 2024

Objectives: This methodology paper outlines a mixed-methods study design to: (i) further validate the Child Health Epidemiology Reference Group (CHERG) Verbal-Social Autopsy (VASA) tool quantitatively on a larger representative sample in Karachi, (ii) gather qualitative feedback from users, and (iii) refine the tool accordingly to optimize its use investigating under-5 mortality in urban Pakistan.
Methods: An explanatory sequential mixed methods design will be applied to revalidate the CHERG VASA tool in 7 districts of Karachi. The quantitative arm will validate the tool through analysis of data from under-5 deaths identified via stratified random sampling. Validation techniques will include assessment of criterion validity against hospital records, content validity, construct validity, reliability analysis. This will be followed by a qualitative component with cognitive interviews and focus group discussions with respondents to illicit feedback on user experiences with the tool. Qualitative data will undergo framework analysis. Tool refinement will occur integrating both quantitative and qualitative findings.
Discussion: Combining robust statistical validation from a substantial representative sample with in-depth qualitative insights on tool design and functionality will lead to an enhanced context-specific instrument to reliably investigate determinants of under-5 mortality in the slums of Karachi, Pakistan’s largest city.
Keywords: verbal autopsy, social autopsy, validity, reliability, scale validation, mixed-methods
Addressing the Silent Threat: Enhancing Resilience in a Dynamic Climate - Safeguarding Women and Children's Health through Affordable, Sustainable Measures
Authors: Mumtaz Seema N. 
Published: April 2024

The purpose of this letter to the editor is to demand rapid action and provide solutions that are both inexpensive and sustainable in order to address the severe health dangers that are presented by climate change, especially for particularly vulnerable women and children. In order to improve food security, cultural preservation, and disease prevention, these solutions focus the empowerment of women via programs such as community seed banks and knowledge networks. Additionally, they revive traditional knowledge such as the use of medicinal plants. Additionally, the letter places an emphasis on community-driven solutions such as early warning systems and disaster preparation training. Additionally, the letter addresses the gender component of climate change by addressing initiatives that empower women and enhance their well-being. In conclusion, it urges all parties involved, including governments, organizations, and people, to work together to emphasize the empowerment of women, climate-smart agriculture, and resilient healthcare systems in order to construct a future that is more fair and robust for everyone.
Keywords: Climate change, women, children, health, resilience
Cross-sectional association between 24-hour movement guidelines and depressive symptoms in Chinese university students
Authors: Zhang Yanqing , Chi Xinli , Huang Liuyue , Yang Xingyi , Chen Sitong 
Published: April 2024

Background
The world’s first 24-h movement guidelines for adults were released on 15 October 2020 in Canada, though evidence of their associations with health indicators in young adults is sparse. This study aimed to report the prevalence of meeting the 24-h movement guidelines and associations with depressive symptoms in a sample of Chinese university students.

Methods
Cross-sectional data from 1,793 Chinese university students (mean age = 20.7 years, 63.6% female) were used. Sociodemographic information, movement behaviors (physical activity, sedentary behavior, and sleep duration), and depressive symptoms were collected using a self-reported questionnaire.

Results
The prevalence of meeting the 24-h movement guidelines was 27.8% in Chinese university students. Logistic regression results show that compared to those who met the 24-h movement guidelines, odds ratio (OR) for depressive symptoms in those who met fewer recommendations contained in the 24-h movement guidelines were significantly higher (OR for none = 3.4, 95% CI [2.1–5.5], p < 0.001; OR for one = 2.7, 95% CI [2.0–3.8], p < 0.001; OR for two = 1.5, 95% CI [1.1–2.1], p = 0.013).

Conclusion
The prevalence of meeting the 24-h movement guidelines in Chinese university students was relatively low and should be enhanced through multiple strategies. Meeting the 24-h movement guidelines was associated with lower risk for depression in Chinese young adults. It is suggested that moving more, sitting less and sleeping well in this population may reduce the occurrence of depression.
Soil organic nitrogen variation shaped by diverse agroecosystems in a typical karst area: evidence from isotopic geochemistry
Authors: Han Ruiyin , Zhang Qian , Xu Zhifang 
Published: April 2024

Background
Soil organic nitrogen (SON) levels can respond effectively to crop metabolism and are directly related to soil productivity. However, simultaneous comparisons of SON dynamics using isotopic tracing in diverse agroecosystems are lacking, especially in karst areas with fragile ecology.

Methods
To better understand the response of SON dynamics to environmental changes under the coupling of natural and anthropogenic disturbances, SON contents and their stable N isotope (δ15NSON) compositions were determined in abandoned cropland (AC, n = 16), grazing shrubland (GS, n = 11), and secondary forest land (SF, n = 20) from a typical karst area in southwest China.

Results
The SON contents in the SF (mean: 0.09%) and AC (mean: 0.10%) profiles were obviously lower than those in the GS profile (mean: 0.31%). The δ15NSON values ranged from 4.35‰–7.59‰, 3.79‰–7.23‰, and 1.87‰–7.08‰ for the SF, AC, and GS profiles, respectively. Decomposition of organic matter controlled the SON variations in the secondary forest land by the covered vegetation, and that in the grazing shrubland by goat excreta. δ15NSON ranges were controlled by the covered vegetation, and the δ15NSON fractionations during SON transformation were influenced by microorganisms in all surface soil.

Conclusions
The excreta of goats that contained 15N-enriched SON induced a heavier δ15NSON composition in the grazed shrubland. Long-term cultivation consumes SON, whereas moderate grazing increases SON content to reduce the risk of soil degradation. This study suggests that optimized crop-livestock production may benefit the sustainable development of agroecosystems in karst regions.
Petroleum Products Pricing and Price Stability in Nigeria: An ARDL Investigation
Authors: Abdullahi Ibrahim Alhaji , Alwell Nteegah, , Ijeoma Kalu, 
Published: April 2024

This study employed the Autoregressive Distributed lag (ARDL) technique to investigate the effect of petroleum products pricing on price level in Nigeria over the period 1990 – 2022. In order to achieve the purpose of the study, data on inflation rate, price of premium motor spirit, price of automotive gas oil, price of household kerosene, price of compressed natural gas and price of crude oil were sourced from secondary source. The results of our analysis revealed that: in the long run, prices of Premium motor spirit and compressed natural gas retarded inflation level marginally while prices of automotive gas oil, dual purpose kerosene and crude oil spurred general price level marginally. Prices of premium motor spirit and compressed natural gas fueled inflation in the short run significantly while prices of automotive gas oil and crude retarded general price level. Price of dual-purpose kerosene had mixed but significant effect on price level. The study also found that a long run nexus existed between petroleum product prices and price level in Nigeria. Petroleum product prices had serious implications on the Nigeria’s economy in the short run than long run. Based on this conclusion, the study recommended Increase investment in the downstream petroleum sector and strengthening existing policies in the oil and gas sector as possible measures towards stabilizing price level in Nigeria.
Histopathological and Biochemical Assessment of Annona muricata and Allium sativum Pooled Extract on Testosterone Induced Prostate Hyperplasia in Albino Rats
Authors: Bernardine Okpukpara O. , Peter Achukwu U. , Bernard Kafor N. 
Published: April 2024

Aims: To investigate the effect of pooled extract of Annona muricata (A. muricata) and Allium sativum (A. sativum) on testosterone-induced prostate hyperplasia in male albino rats.
Experimental Procedure: Male albino rats for the study were divided into seven groups identified as A-G groups. Group A and G were used as negative and positive controls with 12 and 5 rats respectively. Male rats in group B-G were induced with 3mg/kg body weight of testosterone propionate injection subcutaneously for 28 days. Animals in group B and C received 100mg/kg body weight of individual Annona muricata and Allium sativum extract respectively, while animals in group D-F received 100mg/kg, 300mg/kg and 600mg/kg body weight of the pooled extracts. We evaluated relative prostate weight(PI),serum prostate specific antigen(PSA),interleukins-6(IL-6), total protein, and histological changes including KI 67 and BCL2 expressions.
Results and Conclusion: The study revealed that pooled extracts of A. muricata and A. sativum significantly inhibited prostatic hyperplasia; decreased PI,serum PSA,IL-6, total protein, and expression of KI 67, far better than the any of the single plant extract in this study. This suggests that pooled extract of A, muricata and A, sativum may be used as a therapeutic agent for prostatic hyperplasia, as a result of the influence of the phytochemical constituents.