bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estrogen sulfotransferase (SULT1E1) expression in benign and malignant human bone tumors
Authors: Svoboda Martin , Thalhammer Theresia , Aust Sylvia , Arrich Ferdi , Assadian Ojan , Toma Cyril D. 
Published: January 2007

AbstractBackground and Objectives17β‐estradiol regulates growth and differentiation in normal and malignant bone. E2 is inactivated to 17β‐estradiol‐sulfate through estrogen sulfotransferase (SULT1E1).ResultsIn an explorative study, SULT1E1 mRNA expression was assessed in a broad range of samples from benign, primary and secondary malignant bone tumors. We detected SULT1E1 mRNA in 31/50 tumor samples (10/19 malignant, 6/13 benign tumors; 15/18 metastases). Significantly more SULT1E1‐positive samples were found in metastases than in primary bone tumors (P = 0.019). Yet, there was no difference between malignant and benign primary tumors (P = 0.718). SULT1E1 mRNA levels were not related to patients' age, gender, tumor location, stage, grading, and chemotherapy pretreatment. Relative SULT1E1 mRNA levels did not correlate with that of estrogen‐receptor alpha (ERα) as assessed by quantitative TaqMan PCR (10 malignant, 8 benign tissue samples). In the latter, ERα mRNA, but not SULT1E1 mRNA levels were significantly lower than in the malignant samples (P = 0.006 and P = 0.71, respectively). Also, pronounced expression of SULT1E1 mRNA but not of ERα mRNA was observed in osteosarcoma (MG‐63, HOS) and Ewing's sarcoma (TC‐71) cells, while human osteoblasts and BMSC contained ERα but not SULT1E1 mRNA.ConclusionFrequent expression of SULT1E1 mRNA in various human bone tumors suggests that sulfonation might be important to control E2 levels and activity. J. Surg. Oncol. 2007;95:572–581. © 2007 Wiley‐Liss, Inc.
The correlation of extranodal invasion with other prognostic parameters in lymph node positive breast cancer
Authors: Altinyollar Hüseyin , Berberoğlu Uğur , Gülben Kaptan , İrkin Fikret 
Published: January 2007

AbstractBackgroundThe presence of extranodal invasion (ENI) in the metastatic lymph nodes is reported to increase the risk of locoregional recurrence while shortening disease‐free and overall survival in patients with breast cancer. In this study the relationship between ENI and other prognostic parameters and survival is investigated.MethodsOf 650 patients with breast cancer who were treated in Ankara Oncology Teaching and Research Hospital from 1996 to 2003, 368 (56.6%) had lymph node metastasis. The patients with axillary metastasis were separated into two groups as with and without invasion to lymph node capsule and the surrounding adipose tissue. Clinicopathologic features were analyzed by univariate and multivariate logistic regression.ResultsOf 368 patients with axillary metastasis, 135 (36.7%) had ENI. Based on multivariate analysis; the number of metastatic lymph nodes, lymphatic invasion, and tumor necrosis were found to be related with ENI. In the group with ENI, 5‐year overall survival rate was 74.8%, compared to 82.3% for patients without ENI which was significantly lower (P = 0.04).ConclusionsIn lymph node positive breast cancer with presence of ENI, adverse prognostic parameters are more frequently encountered and has a worse overall survival compared to group without ENI. J. Surg. Oncol. 2007;95:567–571. © 2007 Wiley‐Liss, Inc.
Influences on what consumers know and what they think they know regarding marketer pricing tactics
Authors: Carlson Jay P. , Bearden William O. , Hardesty David M. 
Published: January 2007

AbstractAlthough a considerable amount of research has investigated consumer knowledge of individual prices, consumer knowledge of marketer pricing tactics (e.g., partitioned prices, pennies a day) has received only limited attention. In the current research, a model depicting hypothesized antecedents of consumer knowledge (both accurate and self‐perceived) regarding pricing tactics marketers use is proposed and then investigated in two studies. Tests of the model provided support for the hypothesized antecedents of both objective and subjective pricing tactic knowledge and suggested that experience is a key moderator of the objective pricing tactic knowledge–subjective pricing tactic knowledge relationship. © 2007 Wiley Periodicals, Inc.
The effect of knowledge types on consumer‐perceived risk and adoption of genetically modified foods
Authors: Klerck Deon , Sweeney Jillian C. 
Published: January 2007

AbstractScientists have asserted that genetically modified (GM) food offers financial, environmental, health, and quality benefits to society, but the realization of such benefits depends on consumer acceptance of this new technology. Consumer concerns about GM food raise questions about what consumers know about GM food and to what extent this knowledge translates into their evaluations of GM products. The present research empirically examines the effect of both objective and subjective knowledge on perceived risk and, in turn, key consumer behaviors associated with GM food. The results reveal that objective knowledge about GM food significantly reduces performance and psychological risks, whereas subjective knowledge influences only physical risk, and the valence of that impact depends on the level of the consumer's objective knowledge. Furthermore, different risk types enhance consumers' information search and reduce their propensity to buy GM food. The overall findings thus suggest the need for cooperation among government, scientific institutions, and the food industry to foster effective communication strategies that increase consumers' objective knowledge, reduce their risk perceptions, and encourage consumer adoptions of GM technology. © 2007 Wiley Periodicals, Inc.
How to assess motor impairment in writer's cramp
Authors: Zeuner Kirsten E. , Peller Martin , Knutzen Arne , Holler Iris , Münchau Alexander , Hallett Mark , Deuschl Günther , Siebner Hartwig R. 
Published: January 2007

AbstractWriter's cramp is a task‐specific hand dystonia affecting handwriting. Clinical scores such as the Arm Dystonia Disability Scale (ADDS) or Writer's Cramp Rating Scale (WCRS) as well as kinematic analysis of handwriting movements have been used to assess functional impairment in affected patients. In 21 patients with writer's cramp and healthy controls, we analyzed the kinematics of writing and cyclic drawing movements. We rated the severity of dystonia using the ADDS and WCRS and correlated the clinical scores with movement kinematics. Mean stroke frequency was significantly reduced in dystonic patients. Drawing movements showed more frequently a decrease in stroke frequency than handwriting movements. During circle drawing, mean vertical peak velocity was more variable in patients relative to controls, indicating an impaired ability to reproduce the same kinematic pattern over time. An increase in vertical writing pressure was only observed during handwriting but not during circle drawing and may reflect a compensatory effort to stabilize the pencil. Kinematic measures and individual ADDS and WCRS scores did not correlate with each other. The lack of correlation is not surprising as ADDS, WCRS, and kinematic analysis probe different aspects of motor impairment. The ADDS characterizes how dystonia affects a set of fine manual tasks, whereas the WCRS scores the manifestation of dystonia during handwriting. Therefore, the clinical scores and kinematic analysis of handwriting provide complementary insights into motor impairment. Future studies need to address which combination of clinical scores and kinematic measures are most appropriate to quantify impairment in writer's cramp. © 2006 Movement Disorder Society
Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease
Authors: Nakamura Ken , Christine Chadwick W. , Starr Philip A. , Marks William J. 
Published: January 2007

AbstractDeep brain stimulation (DBS) is an effective treatment for selected patients with disabling Parkinson's disease (PD). The two main targets are the subthalamic nucleus (STN) and the globus pallidus internus (GPi), although it has not been established whether stimulation at one target is superior to the other. This prospective randomized study assessed the effects of unilateral DBS of the STN versus GPi on fine motor skills in 33 patients with advanced PD. Stimulation of either the STN (18 subjects) or GPi (15 subjects) in the off medication state significantly improved movement time and dexterity, but had little or no effect on reaction time. Overall, the extent of improvement did not differ between the two targets. The degree of improvement in movement time, but not dexterity, was correlated with the extent of preoperative medication responsiveness. Our findings suggest that DBS of the STN or GPi results in a similar improvement in hand movements at short‐term follow‐up. Preoperative medication responsiveness predicts improvement in some but not other motor tasks. © 2006 Movement Disorder Society
Proteasome inhibitor model of Parkinson's disease in mice is confounded by neurotoxicity of the ethanol vehicle
Authors: Landau Anne M. , Kouassi Edouard , Siegrist‐Johnstone Rosmarie , Desbarats Julie 
Published: January 2007

AbstractDefects in the ubiquitin‐proteasome system have been implicated in Parkinson's Disease (PD). Recently, a rat model of PD was developed using a synthetic proteasome inhibitor (PSI), (Z‐lle‐Glu(OtBu)‐Ala‐Leu‐al). We attempted to transfer this model to mouse studies, where genetics can be more readily investigated due to the availability of genetically modified mice. We treated C57BL/6 (B6) mice with six intraperitoneal injections of 6 mg/kg PSI in 50 μl of 70% ethanol over a 2‐week‐period. We found significant decreases in nigrostriatal dopamine in PSI‐treated mice compared with saline‐treated mice. However, we observed similar decreases in the ethanol‐treated vehicle control group. Administration of ethanol alone led to significant long‐term alterations in dopamine levels. Ethanol significantly eclipses the effects of PSI in the dopamine system, and therefore is a confounding vehicle for this model. © 2006 Movement Disorder Society
Validity of Hamilton depression inventory in Parkinson's disease
Authors: Dissanayaka Nadeeka N.W. , Sellbach Anna , Matheson Sally , Marsh Rodney , Silburn Peter A. , O'Sullivan John D. , Byrne Gerard J. , Mellick George D. 
Published: January 2007

AbstractStudies investigating the assessment of depression in Parkinson's disease (PD) are limited. We examined the concurrent validity and the internal consistency of the Hamilton Depression Inventory (HDI) and compared it to the Hamilton and Geriatric Depression Scales. PD patients (n = 79) were recruited from neurology clinics. Diagnosis of depressive disorder was made according to DSM‐IV criteria. Receiver operating characteristic curves were used to calculate sensitivity, specificity, and positive and negative predictive values. The HDI exhibited an optimal cutoff for discriminating between depressed and nondepressed PD patients of 13.5/14.0 and is a valid instrument to use in the setting of PD. © 2006 Movement Disorder Society
Pattern of subclinical pulmonary dysfunctions in Parkinson's disease and the effect of levodopa
Authors: Pal Pramod Kumar , Sathyaprabha Talakad N. , Tuhina Prasad , Thennarasu Kandavel 
Published: January 2007

AbstractWe performed a detailed evaluation of pulmonary function in 53 patients with idiopathic Parkinson's disease (PD) who did not have symptoms of pulmonary or cardiac dysfunction. There was a significant pulmonary dysfunction of restrictive type which partially responded to levodopa. Compared to men, women were more severely affected. Pulmonary function assessment is recommended in PD, irrespective of severity of disease. © 2007 Movement Disorder Society
ELAVL4, PARK10, and the Celts
Authors: Haugarvoll Kristoffer , Toft Mathias , Ross Owen A. , Stone Jeremy T. , Heckman Michael G. , White Linda R. , Lynch Timothy , Gibson John Mark , Wszolek Zbigniew K. , Uitti Ryan J. , Aasly Jan O. , Farrer Matthew J. 
Published: January 2007

AbstractGenetic variability in ELAVL4 located in the PARK10 locus was recently associated with age‐at‐onset (AAO) in a series of Parkinson's disease (PD) patients originating from the United States. We examined five markers spanning ELAVL4 in Norwegian, United States, and Irish PD case–control samples. No association was found between the examined markers and AAO or PD in Norwegian or US samples. However, ELAVL4 markers (rs967582 and rs3902720) were significantly associated with susceptibility to PD in our Irish series. Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic‐founder effect. © 2007 Movement Disorder Society
Apolipoprotein E ε4 allele is associated with Parkinson disease risk in a Mexican Mestizo population
Authors: López Marisol , Guerrero Jorge , Yescas Petra , Boll Marie‐Catherine , Familiar Itziar , Ochoa Adriana , Rasmussen Astrid , Alonso María Elisa 
Published: January 2007

AbstractWe investigated the association between apolipoprotein E (APOE) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE‐ε4 allele and APOE ε4/ε3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025). © 2006 Movement Disorder Society
G2019S mutation in the leucine‐rich repeat kinase 2 gene is not associated with multiple system atrophy
Authors: Ozelius Laurie J. , Foroud Tatiana , May Susanne , Senthil Geetha , Sandroni Paola , Low Phillip A. , Reich Stephen , Colcher Amy , Stern Matthew B. , Ondo William G. , Jankovic Joseph , Huang Neng , Tanner Caroline M. , Novak Peter , Gilman Sid , Marshall Frederick J. , Wooten G. Frederick , Chelimsky Thomas C. , Shults Clifford W. ,   The North American Multiple System Atrophy Study Group
Published: January 2007

AbstractMultiple system atrophy (MSA) is characterized clinically by Parkinsonism, cerebellar dysfunction, and autonomic impairment. Multiple mutations in the LRRK2 gene are associated with parkinsonian disorders, and the most common one, the G2019S mutation, has been found in ∼1% of sporadic cases of Parkinsonism. In a well‐characterized cohort of 136 subjects with probable MSA and 110 neurologically evaluated control subjects, none carried the G2019S mutation. We conclude that the G2019S mutation in the LRRK2 gene is unlikely to be associated with MSA. © 2007 Movement Disorder Society
Characteristics of sensory trick‐like manoeuvres in jaw‐opening dystonia
Authors: Schramm Axel , Classen Joseph , Reiners Karlheinz , Naumann Markus 
Published: January 2007

AbstractWe evaluated the effect of different manipulations on the performance of a standardized counting task in 7 patients with idiopathic jaw‐opening dystonia. Patients used a small stick as sensory stimulus. Following conditions were examined: stick placed between teeth and cheek (CHEEK), biting on stick (TEETH), voluntary jaw occlusion without stick (OCCLUSION). Articulation was rated by patients and experimenters and surface electromyographic activity (EMG) was recorded. Patient‐rating (CHEEK ‐ 36.6%, TEETH ‐ 48.1%) and EMG (−18.1%; −17.3%) were significantly improved for conditions using the stick, whereas experimenter‐rating showed a trend for TEETH (−16.2%). Although jaw occlusion during speaking deteriorates articulation in healthy subjects, there was no further deterioration in patients and EMG was even significantly reduced (−18.6%). Comparable results were obtained in 1 patient using a special dental device. We conclude that sensory tricks significantly improve subjective and objective parameters. Besides tactile stimulation, altered proprioceptive feedback and antagonist activation may modulate hyperactive dystonic networks. © 2007 Movement Disorder Society
Postural responses to continuous unilateral neck muscle vibration in standing patients with cervical dystonia
Authors: Bove Marco , Brichetto Giampaolo , Abbruzzese Giovanni , Marchese Roberta , Schieppati Marco 
Published: January 2007

AbstractSeveral observations support the notion that integration of neck proprioceptive input is impaired in cervical dystonia (CD). An example is the inconsistent or opposite to normal effect of lateral neck muscle vibration on body rotation during stepping. We hypothesized that lateral neck vibration produces abnormal responses also in a static task. Normal subjects and patients with CD stood quietly with eyes closed, without or with vibration applied to the sternocleidomastoid muscle, and center of foot pressure and body sway were recorded by a dynamometric platform. Patients had a larger than normal sway under control condition. They showed little or no postural responses to vibration. When body tilt occurred, it was rarely in the frontal plane as in normal subjects, but in the sagittal plane. No relationship existed between vibration‐induced tilt during stance and body rotation during stepping. Therefore, in CD, proprioceptive neck input is less used for the construction of the postural vertical during quiet stance than it is used for the definition of the subjective straight ahead during a dynamic task. © 2007 Movement Disorder Society
Asymptotic analysis of flow in wavy tubes and simulation of the extrusion process
Authors: Ainser A. , Dupuy D. , Panasenko G. P. , Sirakov I. 
Published: January 2007

AbstractThe paper is devoted to the mathematical modelling of an extrusion process. Usually, an extruder has a very complicated geometry. This generates a lot of difficulties for computations of three‐dimensional flows. In the present paper, we develop and justify the asymptotic domain decomposition strategy in order to parallelize the computational process and reduce the memory. The error estimates are proved for the Stokes steady‐state equation in the two‐dimensional and three‐dimensional cases. Then, the asymptotic domain decomposition procedure is applied for numerical testing and computations of the non‐Newtonian fluid simulating a real process of the polymer extrusion. Copyright © 2007 John Wiley & Sons, Ltd.
Central core disease due to recessive mutations in RYR1 gene: Is it more common than described?
Authors: Kossugue Patrícia M. , Paim Júlia F. , Navarro Monica M. , Silva Helga C. , Pavanello Rita C. M. , Gurgel‐Giannetti Juliana , Zatz Mayana , Vainzof Mariz 
Published: January 2007

AbstractCentral core disease (CCD) is an autosomal‐dominant congenital myopathy, with muscle weakness and malignant hyperthermia (MH) susceptibility. We identified two of nine Brazilian CCD families carrying two mutations in the RYR1 gene. The heterozygous parents were clinically asymptomatic, and patients were mildly affected, differing from the few autosomal‐recessive cases described previously. Recessive inheritance in CCD may therefore be more common than previously appreciated, which has important implications for genetic counseling and MH prevention in affected families. Muscle Nerve, 2007
Material Simulation and Damage Analysis at Thermal Shock Conditions
Authors: Gockel Franz‐Barthold , Mahnken Rolf 
Published: January 2007

AbstractThermal shock is an extreme form of thermo‐mechanical loading. This detailed investigation close to reality is necessary in industrial engineering in order to get a good prediction of life expectancy for high quality and safety relevant machine components. This paper addresses on experimental investigations of deformation and damage at thermal shocked cylinders. Additionally the parameters for the Chaboche model are identified on the basis of uniaxial cyclic experiments. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Modelling crack initiation by means of finite fracture mechanics
Authors: Hebel Jochen , Becker Wilfried 
Published: January 2007

AbstractIn this study, a generally applicable hybrid criterion for brittle crack initiation overcoming deficiencies of classical approaches is applied to regular and singular stress concentrations. Possible formulations of the resulting optimisation problem for the failure load are discussed. Examples demonstrate the capability of the model to cover relevant effects as well as a versatile finite element analysis procedure for notch problems. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Evolution of Elastic T‐stresses of Growing Mixed‐Mode Cracks
Authors: M.‐Abbasi Kianoush , Schütte Henning 
Published: January 2007

AbstractFinite element simulations of growing mixed‐mode central line‐cracks (2‐D case) and internal penny‐shaped cracks (3‐D case) have been performed to address the evolution of the elastic T‐stresses acting at the crack‐tip (the non‐singular stress terms in the stress expansion formula at the crack‐front). (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Formulation of the Material Force Approach for Finite Inelasticity
Authors: Näser Bastian , Kaliske Michael , Müller Ralf , Meiners Christian 
Published: January 2007

AbstractThe material forces represent the thermodynamically driving forces on any kind of inhomogeneity and discontinuity. For comprehensive investigations, the balance of the inverse motion problem has to be formulated and evaluated to separate different portions of the material forces arising from different inhomogeneities and discontinuities. This paper presents a general approach for inelastic material models based on the multiplicative split of the deformation gradient in order to calculate the J ‐integral of an inelastic crack tip. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Numerical modeling of brittle fracture in porous CFC‐materials
Authors: Piat Romana 
Published: January 2007

AbstractBoth energy and stress criteria are necessary conditions for fracture but neither the one nor the other is sufficient. A combination of these criteria is proposed in [1]. This combined criterion is used for numerical simulation of crack propagation by the 4‐point bending test in porous materials. Examples of such materials are carbon‐carbon composites (CFC) [2, 3]. Micrographs of the cross‐sections of these materials are used for FEM modeling of the crack propagation on the basis of the proposed criterion. Results of the numerical modeling are compared with experimental results. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
On the elastic symmetries of growing mixed‐mode cracks
Authors: Schütte Henning , M.‐Abbasi Kianoush 
Published: January 2007

AbstractMany continuum damage mechanics models for quasi‐brittle materials are based on the reduction of stiffness due to elliptical crack or penny‐shaped microcracks in the material. Because of this a numerical study of growing elliptical cracks in a unit cube is undertaken with the help of an FEM simulation.The propagation of the crack is governed by the principle of maximum driving force [1]. For each propagation step the tensor of elasticity is calculated and its symmetries are analyzed. It will be shown that the elastic symmetry in each step is close to orthotropy and can be approximated by an elliptical crack. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)