bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of maternal respiratory infections during pregnancy on infant lung function
Authors: Putte‐Katier Nienke Van , Uiterwaal Cuno S.P.M. , De Jong Brita M. , Kimpen Jan L.L. , Verheij Theo J.M. , Van Der Ent Cornelis K. 
Published: August 2007

AbstractIntroductionWe studied whether maternal respiratory infections during pregnancy adversely influence lung growth and development of the offspring, resulting in poor early life lung function.MethodsInfants were participants of the Wheezing Illnesses Study Leidsche Rijn (WHISTLER). Lung function measurements (single occlusion technique) were performed during natural sleep. Questionnaire data were used to obtain information on maternal respiratory infections during pregnancy. Multivariate analysis was conducted to assess the relationship between maternal respiratory infections during pregnancy and resistance and compliance of the respiratory system, adjusting for potential confounding variables.ResultsLower values of compliance (Crs) were found in infants of mothers with respiratory infections during pregnancy; Crs fell by 5.5% (P = 0.031). The difference in Crs between infants of mothers with and without respiratory infections during pregnancy remained unchanged and statistically significant after adjusting for potential confounding variables. The more respiratory infections the mother experienced during pregnancy, the lower the value of Crs was in her offspring (P for trend = 0.016). Using Crs corrected for body weight the relationship with maternal infections was non‐significant, however still showing a trend.ConclusionsThe results of this study may indicate that mothers who experience respiratory infections during pregnancy have newborns with lower compliance of the respiratory system. Pediatr Pulmonol. 2007; 42:945–951. © 2007 Wiley‐Liss, Inc.
Antiplatelet and antithrombotic activity of indole‐3‐carbinol in vitro and in vivo
Authors: Park Min‐Kyu , Rhee Yun‐Hee , Lee Hyo‐Jung , Lee Eun‐Ok , Kim Kwan‐Hyun , Park Min‐Jong , Jeon Byung‐Hun , Shim Bum‐Sang , Jung Chang‐Hyun , Choi Seung‐Hoon , Ahn Kyoo‐Seok , Kim Sung‐Hoon 
Published: August 2007

AbstractIndole‐3‐carbinol, a natural compound found in cruciferous vegetables, is known to have anticancer activity. In the present study, the antiplatelet and antithrombotic activities of indole‐3‐carbinol were investigated in vitro and in vivo. Indole‐3‐carbinol significantly inhibited collagen‐induced platelet aggregation in human platelet rich plasma (PRP) in a concentration‐dependent manner. Indole‐3‐carbinol significantly inhibited fibrinogen binding to the platelet surface glycoprotein IIb/IIIa (GP IIb/IIIa) receptor by flow cytometric analysis. In addition, the levels of thromboxane B2 (TXB2) and prostaglandin E2 (PGE2) in collagen stimulated PRP were significantly inhibited in a concentration‐dependent manner by indole‐3‐carbinol. Furthermore, indole‐3‐carbinol dose‐dependently suppressed the death of mice with pulmonary thrombosis induced by intravenous injection of collagen and epinephrine. These results suggest that indole‐3‐carbinol can be a potent antithrombotic agent with antiplatelet activity through the inhibition of GP IIb/IIIa receptor and thromboxane B2 formation. Copyright © 2007 John Wiley & Sons, Ltd.
Flavonoids from Chinese Viscum coloratum produce cytoprotective effects against ischemic myocardial injuries: inhibitory effect of flavonoids on PAF‐Induced Ca2+ overload
Authors: Chu Wenfeng , Qiao Guofen , Bai Yunlong , Pan Zhenwei , Li Guoyu , Piao Xianmei , Wu Ling , Lu Yanjie , Yang Baofeng 
Published: August 2007

AbstractViscum coloratum has been used in the indigenous system of medicine for the treatment of various diseases such as myocardial ischemia and arrhythmia. Platelet‐activating factor (PAF) is an important player in cardiovascular diseases. The aim of this study was to investigate the protective effects of Viscum coloratum flavonoids (VCF) against ischemic myocardial injuries in vivo and to further investigate its regulatory effect on PAF. Studies were performed in a rat model of myocardial infarction and in isolated myocytes. It was found that VCF relieved myocardial injuries during ischemia. PAF (10−11 m) significantly increased the intracellular free Ca2+ concentration ([Ca2+]i) and VCF inhibited the changes induced by PAF in single cardiac myocytes. The results suggest that VCF can improve cardiac function and that VCF reduces ischemic myocardial injuries via blocking the signaling pathway of PAF. Therefore, PAF blockers may be candidate drugs for preventing cardiac injuries during ischemia/reperfusion, and subsequently improving cardiac function. Copyright © 2007 John Wiley & Sons, Ltd.
Antigenotoxic effect of extract from Cynara cardunculus L.
Authors: Miadokova E. , Nadova S. , Vlckova V. , Duhova V. , Kopaskova M. , Cipak L. , Rauko P. , Mucaji P. , Grancai D. 
Published: August 2007

AbstractThe extract of artichoke Cynara cardunculus L. (CCE) was investigated for its potential antigenotoxic and antioxidant effects using four experimental model systems. In the Saccharomyces cerevisiae mutagenicity/antimutagenicity assay, CCE significantly reduced the frequency of 4‐nitroquinoline‐N‐oxide‐induced revertants at the ilv1 locus and mitotic gene convertants at the trp5 locus in the diploid Saccharomyces cerevisiae tester strain D7. In the simultaneous toxicity and clastogenicity/anticlastogenicity assay, it exerted an anticlastogenic effect against N‐nitroso‐N′‐methylurea‐induced clastogenicity in the plant species Vicia sativa L. On the contrary, despite CCE not being mutagenic itself, in the preincubation Ames assay with metabolic activation, it significantly increased the mutagenic effect of 2‐aminofluorene in the bacterial strain Salmonella typhimurium TA98. In the 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) free radical scavenging assay, CCE exhibited considerable antioxidant activity. The SC50 value representing 0.0054% CCE corresponds to an antioxidant activity of 216.8 µm ascorbic acid which was used as a reference compound. Although the mechanism of CCE action still remains to be elucidated, different possible mechanisms are probably involved in the CCE antigenotoxic effects. It could be concluded that CCE is of particular interest as a suitable candidate for an effective chemopreventive agent. Copyright © 2007 John Wiley & Sons, Ltd.
Protective effect of Amomi semen extract on alloxan‐induced pancreatic β‐cell damage
Authors: Lee Ji‐Hyun , Park Jin‐Woo , Kim Jong‐Suk , Park Byung‐Hyun , Rho Hye‐Won 
Published: August 2007

AbstractThe protective effect of Amomi semen extract (ASE) on alloxan‐induced pancreatic β‐cell damage was investigated in HIT T‐15 cells, a Syrian hamster pancreatic β‐cell line. Alloxan caused pancreatic β‐cell damage through the generation of reactive oxygen species (ROS), the elevation of cytosolic free Ca2+, DNA fragmentation and the decrease of cellular NAD+ and ATP levels. All these effects of alloxan were significantly prevented by pretreatment with a water‐soluble extract of Amomi semen. Pretreatment with ASE in pancreatic islets isolated from mice, also significantly abolished the inhibition of glucose‐stimulated insulin secretion by alloxan. The results of this study provide evidence that ASE may have a protective activity on alloxan‐induced β‐cell damage, and that the protective effect is primarily due to the inhibition of ROS generation by alloxan. Copyright © 2007 John Wiley & Sons, Ltd.
The antidiabetic activity of total lignan from Fructus Arctii against alloxan‐induced diabetes in mice and rats
Authors: Xu Zhaohui , Wang Xiaoyan , Zhou Mingmei , Ma Liping , Deng Yi , Zhang Hanjie , Zhao Aihua , Zhang Yongyu , Jia Wei 
Published: August 2007

AbstractThe antidiabetic activity of the total lignan from the plant Fructus Arctii, used in China for the control of diabetes, was investigated in models of alloxan‐induced diabetic mice and hyperglycemic‐hyperlipidemic diabetic rats. The biochemical parameters studied were: blood glucose, glucose tolerance, serum insulin, serum triglycerides, total cholesterol and high density lipoprotein (HDL). Total lignan was given to mice and rats daily for 10 days at doses of 2.0, 1.0, 0.5 g/kg and 1.38, 0.69, 0.35 g/kg respectively. The alloxan‐diabetic animals showed significant reductions in plasma glucose, triglycerides and total cholesterol after treatment with the total lignan from the plant Fructus Arctii and glibenclamide (used as standard) compared with the diabetic controls, while the glucose tolerance, serum insulin level and HDL‐cholesterol were elevated without the risk of hypoglycemia. In conclusion, the total lignan from the plant Fructus Arctii has been proven to be a safer antidiabetic agent and might help to prevent diabetic complications. It can serve as a good adjuvant in the present armamentarium of antidiabetic drugs. Copyright © 2007 John Wiley & Sons, Ltd.
Antiinflammatory activities of Rubus coreanus depend on the degree of fruit ripening
Authors: Yang Hyun Mo , Oh Sun‐mee , Lim Soon Sung , Shin Hyun‐Kyung , Oh Yang‐Seok , Kim Jin‐Kyung 
Published: August 2007

AbstractThe dried unripe fruit of Rubus coreanus, which is well‐known in Korea and referred to as ‘Bok‐bun‐ja’, has been employed as a traditional medicine for centuries. This crude drug is utilized in Korea for the management of impotence, spermatorrhea, enuresis, asthma and allergic diseases. The principal objective of the present study was to conduct a comparison of the antiinflammatory effects of ethanol extracts of the unripe (URCE), half‐ripened (HRCE) and ripe fruits (RCE) of Rubus coreanus. URCE and HRCE were found to reduce the production of nitric oxide (NO) and prostaglandin E2 (PGE2) as well as pro‐inflammatory cytokines, in lipopolysaccharide (LPS)‐stimulated RAW264.7 murine macrophages. However, RCE exerted no inhibitory effects against the production of NO and IL‐6. The results of the study show that the degree of fruit ripening of Rubus coreanus affects the production of inflammatory mediators such as NO, PGE2 and inflammatory cytokines. Copyright © 2007 John Wiley & Sons, Ltd.
Inhibition of non‐enzymatic glycation by silk extracts from a Mexican land race and modern inbred lines of maize (Zea mays)
Authors: Farsi Darius Arthur , Harris Cory S. , Reid Lana , Bennett Steffany A. L. , Haddad Pierre S. , Martineau Louis C. , Arnason John Thor 
Published: August 2007

AbstractNon‐enzymatic glycation and the accumulation of advanced glycation end products (AGEs) are associated with various disease states, including complications of diabetes and aging. Secondary metabolites from several plant species are known to inhibit non‐enzymatic glycation and the formation of AGEs, including flavonoids found in the style (silk) of Zea mays (maize). Thirteen modern maize inbreds and one land race were tested for in vitro inhibition of non‐enzymatic glycation of bovine serum albumin. Many of the tested extracts exhibited inhibitory activity, in particular the newest inbreds, which were bred for resistance to gibberella ear rot (Fusarium graminearum) and common smut (Ustilago maydis). The most active maize genotype (CO441), displaying an IC50 of 9.5 µg/mL, was more effective than aminoguanidine, a known inhibitor of glycation. Zapalote chico, a land race with high maysin content, showed only moderate inhibitory activity compared with the modern maize genotypes. Antiglycation activity was highly correlated with the total phenolic content of silk extracts and mildly correlated with resistance to certain fungal infections. The results identify modern resistant and high phenolic maize inbreds as promising candidates for the development of natural AGE inhibitors for the prevention and treatment of diabetic complications and the degenerative effects of aging. Copyright © 2007 John Wiley & Sons, Ltd.
Combined effect of chill storage and modified atmosphere packaging on mussels (Mytilus galloprovincialis) preservation
Authors: Goulas Antonios E. 
Published: August 2007

AbstractChanges in biochemical indices, microbial growth, headspace and sensory quality of mussels which had been packaged in two modified atmospheres [Modified atmosphere packaging (MAP) 1: 60% CO2/20% N2/20% O2 and MAP 2: 60% CO2/40% N2] and under vacuum (VP) were studied for 14 days. The results showed better quality retention and greater shelf life of mussels packaged under MAP 1 as compared to MAP 2 and VP samples. Increase in total volatile basic nitrogen followed the order: MAP 1 < MAP 2, VP < air (control) samples while increase in trimethylamine nitrogen followed the order: MAP 1 < air < MAP 2 < VP. The 2‐thiobarbituric acid (TBA) values of MAP 1 and air samples were significantly higher (p < 0.05) than the TBA values of VP and MAP 2 samples. MAP 1 showed a greater (p < 0.05) inhibition effect on total viable count of mussel samples than all other packaging conditions. Based primarily on odour scores, the MAP 1 samples remained acceptable up to ca. 10–11 days, the MAP 2 and VP up to ca. 7–8 days while the air‐packaged samples up to ca. 5–6 days of storage. Copyright © 2007 John Wiley & Sons, Ltd.
New valley ridge inflection point associated to the bifurcation of a valley on potential energy surfaces
Authors: Palmeiro R. , Castaño O. 
Published: August 2007

AbstractThere are currently two definitions of valley ridge inflection point on an adiabatic potential energy surface (PES), one introduced by Basilevsky and the other by Valtazanos and Ruedenberg. Here, we investigate the validity of both definitions on bidimensional surfaces without symmetry constraints, with neither producing completely satisfactory results. Hence, we propose new conditions which must obey a valley bifurcation point (VBP) locally and demonstrate that such conditions are necessary when a valley splits into two, finishing at two energy minima. Finally, we localize such VBPs on the bidimensional surfaces and check the certainty of our previous deductions. © 2007 Wiley Periodicals, Inc. Int J Quantum Chem, 2007
On the effect of large deflection on nonlinear behavior of an eccentric bracing system
Authors: Rasekh Ali , Mofid Massood , Khezrzadeh Hamed 
Published: August 2007

AbstractIn this article, a particular off‐center bracing system is introduced. In this system, the tensile diagonal strut is not straight. When the load is applied, the original geometry changes and thus causes the system to harden. Based on this behavior, a step‐by‐step analytical method is developed. Using this method, a Geometrically Nonlinear Analysis Program (GNAP) is designed to analyze the elastic force–displacement relation. Extension of this program to dynamic analysis led to a Dynamic Nonlinear Analysis Program (DNAP). The object of this article is to show that such bracing systems will lead to less seismic force on such structures compared to classic concentric bracing systems. On the other hand, it will be shown that the bracing system causes semi‐uncoupling of structure, and that the probable excursions in the nonlinear range during severe earthquakes will not cause significant deterioration in its strength and stiffness. Copyright © 2007 John Wiley & Sons, Ltd.
Reward oriented packet filtering algorithm for wireless sensor networks
Authors: Shu Lei , Yang Jie , Zhang Lin , Xu Hui , Wu Xiaoling , Hauswirth Manfred 
Published: August 2007

AbstractPacket filtering used in query process is an important approach to reduce energy consumption in sensor networks.Interestis used as a constraint to filter uninterested data when users query information. Within interested data some are more important because they have more valuable information than that of others. We hope to process these more important data first. In this paper, we firstly definerewardto denote the importance level of data, and then we present a two tiers buffer model as the platform for our ETRI packet filtering algorithm. We especially present two packet filtering algorithms for real time and non‐real time transmissions. Based on simulation result, we find out that both packet filtering algorithms can substantially improve the quality of information and reduce energy consumption. Copyright © 2007 John Wiley & Sons, Ltd.
Isolines: efficient spatio‐temporal data aggregation in sensor networks
Authors: Solis Ignacio , Obraczka Katia 
Published: August 2007

AbstractThis paper introduces an energy‐efficient data collection technique that takes advantage of spatial and temporal data correlation for monitoring continuously changing conditions such as temperature, humidity, rain fall, radiation, substance concentrations, etc. The proposed technique, isoline aggregation, generates contour maps representing the condition being monitored. The resulting contour map consist of isolines which delimit regions within which the monitored condition is within a certain value range. Energy efficiency is achieved by taking advantage of the spatial and temporal correlation of the data field. Simulation results show that isoline aggregation can reduce the amount of bytes transmitted considerably. At the same time, we are able to keep high data accuracy. Copyright © 2007 John Wiley & Sons, Ltd.
X‐ray absorption spectroscopy analysis of Ru in La2RuO5
Authors: Arčon Iztok , Benčan Andreja , Kodre Alojz , Kosec Marija 
Published: August 2007

AbstractThe compound La2RuO5 was examined by the x‐ray absorption spectroscopy (XAS) methods, x‐ray absorption near edge structure (XANES) and extended x‐ray absorption fine structure (EXAFS). XANES technique was used to probe directly the average valence of Ru atoms in the compound. The energy shift of the Ru K‐edge in the XANES signal gave the average Ru valence state as 4.0 ± 0.1. EXAFS analysis provided, by yielding directly the interatomic distances and coordination numbers, the first information on the Ru atom neighborhood, on which the model for the Rietveld refinement of the unit cell of the new compound was devised. Finally, the local structure around the Ru atoms from the refinement was used in the FEFF6 code for a model EXAFS spectrum. The very good quantitative agreement with the measured spectrum proves that the refined crystal structure contains no systematic defects in the vicinity of Ru atoms. This result, together with the valence obtained from XANES, strongly confirms the proposed La2RuO5 stoichiometry. Copyright © 2007 John Wiley & Sons, Ltd.
Functional genomics of commercial baker's yeasts that have different abilities for sugar utilization and high‐sucrose tolerance under different sugar conditions
Authors: Tanaka‐Tsuno Fumiko , Mizukami‐Murata Satomi , Murata Yoshinori , Nakamura Toshihide , Ando Akira , Takagi Hiroshi , Shima Jun 
Published: August 2007

AbstractIn the modern baking industry, high‐sucrose‐tolerant (HS) and maltose‐utilizing (LS) yeast were developed using breeding techniques and are now used commercially. Sugar utilization and high‐sucrose tolerance differ significantly between HS and LS yeasts. We analysed the gene expression profiles of HS and LS yeasts under different sucrose conditions in order to determine their basic physiology. Two‐way hierarchical clustering was performed to obtain the overall patterns of gene expression. The clustering clearly showed that the gene expression patterns of LS yeast differed from those of HS yeast. Quality threshold clustering was used to identify the gene clusters containing upregulated genes (cluster 1) and downregulated genes (cluster 2) under high‐sucrose conditions. Clusters 1 and 2 contained numerous genes involved in carbon and nitrogen metabolism, respectively. The expression level of the genes involved in the metabolism of glycerol and trehalose, which are known to be osmoprotectants, in LS yeast was higher than that in HS yeast under sucrose concentrations of 5–40%. No clear correlation was found between the expression level of the genes involved in the biosynthesis of the osmoprotectants and the intracellular contents of the osmoprotectants. The present gene expression data were compared with data previously reported in a comprehensive analysis of a gene deletion strain collection. Welch's t‐test for this comparison showed that the relative growth rates of the deletion strains whose deletion occurred in genes belonging to cluster 1 were significantly higher than the average growth rates of all deletion strains. Copyright © 2007 John Wiley & Sons, Ltd.
Surgical treatment of missed Monteggia lesions in children
Authors: Lädermann Alexandre , Ceroni Dimitri , Lefèvre Yan , De Rosa Vincenzo , De Coulon Geraldo , Kaelin André 
Published: August 2007

Purpose The treatment of an unrecognized Monteggia lesion continues to pose a therapeutic challenge, as evidenced by the variety of surgical techniques described. Moreover, there are high complication and redislocation rates following surgery. This report concerns a surgical technique to reduce a chronic dislocation of the radial head utilizing an ulnar osteotomy and internal fixation. Methods Six consecutive cases of missed Monteggia lesions were treated in our institution between August 2001 and September 2003. Patient mean age was 6.5 (range 4–8) years, and the mean interval between injury and surgical procedure was 17 (range 1–49) months. Surgery consisted of an ulnar osteotomy with angulation and lengthening, bone grafting at the osteotomy site, and internal fixation. Open reduction of the radial head, repair or reconstruction of the annular ligament or temporary fixation of the radial head with a transarticular wire was not undertaken. Cast immobilization with the forearm in neutral rotation was maintained for 2 weeks. Results There was one case of nonunion. At an average follow-up of 3 (range 1.5–4.4) years, all patients had regained painless function of the forearm, good range of elbow and forearm motion, and maintenance of the radial head reduction. Conclusions Both angulation and elongation of the ulna are required to allow for reduction of the radial head. We do not see any indication for procedures directed at the radio-capitellar joint.
PEPYS IN THE HISTORY OF READING
Authors: JAJDELSKA ELSPETH 
Published: August 2007

ABSTRACTThe history of reading is a comparatively recent field. Work to date has been diverse both in period and methodology, ranging from case studies of individuals to statistical analyses of populations. This diversity means that it can be hard to discern either a broadly agreed narrative of reading practices or a clear set of debates. However, a range of scholars have emphasized contrasts between intensive and extensive reading, oral and silent reading, utilitarian and recreational reading, and public and private reading. These contrasts have been aligned with historical periods, with oral reading, for example, being associated with early modern reading in contrast to later periods. This article analyses the reading practices of Samuel Pepys and concludes that his example supports a contrast between a more intensive, oral, utilitarian, and public reading in the seventeenth century and that of later periods. Pepys's reading practices are also shown to have profound effects on his interpretation of texts. He sees texts of all genres as scripts to be performed by particular individuals, and judges them according to their suitability for this performance in a specific context.