bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Highly Efficient and Direct Approach for Synthesis of Enantiopure β‐Amino Alcohols by Reductive Cross‐Coupling of Chiral N‐tert‐Butanesulfinyl Imines with Aldehydes.
Authors: Zhong Yu‐Wu , Dong Yi‐Zhou , Fang Kai , Izumi Kenji , Xu Ming‐Hua , Lin Guo‐Qiang 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Biological Activity of Substituted Monoamides of Tetrachlorophthalic Acid.
Authors: Dolzhenko A. V. , Kolotova N. V. , Kotegov V. P. , Syropyatov B. Ya. , Vasilyuk M. V. , Rudakova G. V. , Novikova V. V. , Feshin V. P. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Catalytic Asymmetric Synthesis with Rh—Diene Complexes: 1,4‐Addition of Arylboronic Acids to Unsaturated Esters.
Authors: Paquin Jean‐Francois , Stephenson Corey R. J. , Defieber Christian , Carreira Erick M. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
An Anionic Rhodium η4‐Quinonoid Complex as a Multifunctional Catalyst for the Arylation of Aldehydes with Arylboronic Acids.
Authors: Son Seung Uk , Kim Sang Bok , Reingold Jeffrey A. , Carpenter Gene B. , Sweigart Dwight A. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
An Efficient Synthesis of Aryloxyphenyl Cyclopropyl Methanones: A New Class of Antimycobacterial Agents.
Authors: Dwivedi Namrata , Tewari Neetu , Tiwari V. K. , Chaturvedi Vinita , Manju Y. K. , Srivastava A. , Giakwad A. , Sinha S. , Tripathi R. P. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Manganese(III) Acetate Based Oxidative Cyclizations of 3‐Oxopropanenitriles with Conjugated Alkenes and Synthesis of 4,5‐Dihydrofuran‐3‐carbonitriles Containing Heterocycles.
Authors: Yilmaz Mehmet , Uzunalioglu Nese , Pekel A. Tarik 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
One‐Step Assembly of Functionalized γ‐Butyrolactones from Benzoins or Benzaldehydes via an N‐Heterocyclic Carbene Mediated Tandem Reaction.
Authors: Ye Wei , Cai Guanliang , Zhuang Zeyang , Jia Xueshun , Zhai Hongbin 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Bu3SnH‐Mediated 5‐Exo Selective Radical Cyclization of N‐Vinyl‐α,β‐unsaturated Amides Leading to γ‐Lactams.
Authors: Okitsu Takashi , Saito Miho , Tamura Osamu , Ishibashi Hiroyuki 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis, Properties and Antimicrobial Activity of 3‐Hydrazones of 1‐Aryl‐5‐methyl‐1,5‐ethoxycarbonylpyrrolidine‐2,3‐diones.
Authors: Gein V. L. , Gein L. F. , Chirkova M. V. , Mikhalev V. A. , Voronina E. V. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Heterocyclic Quinones in the Nenitzescu Reaction. Synthesis of Furo‐ and Pyrrolobenzothiazoles from 2‐Methyl‐4,7‐dioxobenzothiazole.
Authors: Mukhanova T. I. , Alekseeva L. M. , Shashkov A. S. , Granik V. G. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Three Sesquiterpenoids, Fascicularones E, F, and G Produced by the Fungus Hypholoma fasciculare
Authors: Shiono Yoshihito , Akasaka Hironari , Hiramatsu Fuminori , Sato Kozue , Murayama Tetsuya , Ikeda Michimasa 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
The Use of Zeolites and Other Acid Solids as Catalysts in the Pyrolysis of Polymers in N2 and Air
Authors: Marcilla A. , Gomez A. , Garcia A. N. , Beltran M. , Reyes‐Labarta J. A. , Menargues S. , Olaya M. M. , Hernandez F. , Giner A. , Valdes F. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
The Intramolecular Stille‐Type and the Oxidative Biaryl Coupling Strategies in the Synthesis of New Phenanthro‐Fused Heterocyclic Compounds
Authors: SanMartin Raul , Tellitu Imanol , Herrero Maite , Moreno Isabel , Olivera Roberto , Pascual Sergio , Dominguez Esther 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Molecular Requirements of Lignin—Carbohydrate Complexes for Expression of Unique Biological Activities.
Authors: Sakagami Hiroshi , Hashimoto Ken , Suzuki Fumika , Ogiwara Takako , Satoh Kazue , Ito Hideyuki , Hatano Tsutomu , Takashi Yoshida , Fujisawa Sei‐ichiro 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Phase II study of epirubicin, cisplatin, and capecitabine for advanced biliary tract adenocarcinoma
Authors: Park Se Hoon , Park Yeon Ho , Lee Jeong Nam , Bang Soo‐Mee , Cho Eun Kyung , Shin Dong Bok , Lee Jae Hoon 
Published: December 2005

AbstractBACKGROUNDAdvanced biliary tract carcinomas (BTCs) are associated with a very poor prognosis. New therapeutic strategies therefore are needed to improve efficacy and survival, and the current study was designed with a new, effective drug combination.METHODSPatients with recurrent or metastatic BTC received a combination of epirubicin at a dose of 50 mg/m2, cisplatin at a dose of 60 mg/m2 on Day 1, and capecitabine at a dose of 1000 mg/m2 twice daily for 2 weeks. Treatment was repeated every 3 weeks.RESULTSA total of 43 patients (22 with extrahepatic cholangiocarcinoma, 15 with intrahepatic cholangiocarcinoma, and 6 with gallbladder carcinoma) were treated. The median age was 53 years (range, 36–69 yrs) and 5 patients had a Zubrod performance status of 2. Seventeen patients achieved a partial response (40%; 95% confidence interval [95% CI], 21–49%) and 10 had stable disease. With a follow‐up duration of 18 months, the median survival time was 8 months (95% CI, 6–10 mos). In total, 187 chemotherapy cycles were delivered, with a median of 5 cycles per patient (range, 1–9 cycles). Toxicity was mainly myelosuppression and mucositis, but no patients died of toxicity.CONCLUSIONSThis combination chemotherapy with epirubicin, cisplatin, and capecitabine offered promising antitumor activity in patients with advanced BTC. Cancer 2006. © 2005 American Cancer Society.
Video‐assisted management of malignant pleural effusion in breast carcinoma
Authors: Gasparri Roberto , Leo Francesco , Veronesi Giulia , DePas Tommaso , Colleoni Marco , Maisonneuve Patrick , Pelosi Giuseppe , Galimberti Viviana , Spaggiari Lorenzo 
Published: December 2005

AbstractBACKGROUNDAdvanced breast carcinoma almost always leads to a malignant pleural effusion, conditioning the performance status of patients and consequently quality of life. The treatment of malignant pleural effusion should be a priority in the management of such patients. The results of videothoracoscopic approach (VATS) chemical pleurodesis was analyzed in patients with recurrent pleural effusion from breast carcinoma.METHODSFrom October 1998 to June 2004, 71 consecutive patients with breast carcinoma‐related pleural effusion were treated by the same thoracic‐surgeon team with intracavitary nebulization of 8 g of asbestos‐free sterilized talc via VATS. Multiple pleural biopsies were performed to determine biologic characteristics of recurrent disease.RESULTSTalc pleurodesis was performed in all cases, with no intraoperative or postoperative complications. Median length of hospital stay was 5 days (range, 5–8). The overall success rate of the surgical procedure was 89% (confidence interval [CI], 79–95%) with a mean follow‐up of 22 months (range, 2–81 mos). The overall survival time was 17 months (range, 2–80). Biopsies showed a switch on receptor status and c‐erB‐2 status from negative (primary tumor) to positive (pleural metastasis) in 11 (15%) patients. In another 7 (9.8%) patients, we obtained completely new information that was hitherto unknown.CONCLUSIONTalc pleurodesis via VATS is an effective and safe procedure that yields a high rate of success at the first attempt and achieves long‐term control of malignant pleural effusion due to breast carcinoma. Concomitant biopsies performed during the VATS procedure were a determining factor in the subsequent decision‐making process. Cancer 2006. © 2005 American Cancer Society.
Electron‐Transfer Mediator Microbiosensor Fabrication Based on Immobilizing HRP‐Labeled Au Colloids on Gold Electrode Surface by 11‐Mercaptoundecanoic Acid Monolayer
Authors: Tang Dianping , Yuan Ruo , Chai Yaqin 
Published: December 2005

AbstractIn this paper, a new strategy for constructing a mediator‐type amperometric hydrogen peroxide (H2O2) microbiosensor was described. An electropolymerized thionine film (PTH) was deposited directly onto a gold electrode surface. The resulting redox film was extremely thin, adhered well onto a substrate (electrode), and had a highly cross‐linked network structure. Consequently, horseradish peroxidase (HRP) was successfully immobilized on nanometer‐sized Au colloids, which were supported by thiol‐tailed groups of 11‐mercaptoundecanoic acid (11‐MUA) monolayer covalently bound onto PTH film. With the aid of the PTH mediator, HRP‐labeled Au colloids microbiosensor displayed excellent electrocatalytical response to the reduction of H2O2. This matrix showed a biocompatible microenvironment for retaining the native activity of the covalent HRP and a very low mass transport barrier to the substrate, which provided a fast amperometric response to H2O2. The proposed H2O2 microbiosensor exhibited linear range of 3.5 μM–0.7 mM with a detection limit of 0.05 μM (S/N=3). The response showed a Michaelis‐Menten behavior at larger H2O2 concentrations. The KMapp value for the biosensors based on 24 nm Au colloids was found to be 47 μM, which demonstrated that HRP immobilized on Au colloids exhibited a high affinity to H2O2 with no loss of enzymatic activity. This microbiosensor possessed good analytical performance and storage stability.
Polydivinylbenzene/Ethylvinylbenzene Composite Membranes for the Optimization of a Whole Blood Glucose Sensor
Authors: Bridge Kerry , Davis Frank , Collyer Stuart , Higson Séamus P. J. 
Published: December 2005

AbstractA novel ultra thin polydivinylbenzene/ethylvinylbenzene composite membrane has been developed for use as the outer covering barrier in a model amperometric glucose oxidase enzyme electrode. The composite membrane was formed via the cathodic electropolymerization of divinylbenzene/ethylvinylbenzene at the surface of gold sputter coated host alumina membranes, (serving solely as a mechanical support for the thin polymer film). Permeability coefficients were determined for the enzyme substrates, O2 and glucose, across composite membranes formed with a range of polymer thicknesses. Due to the highly substrate diffusion limiting nature of the composite membrane, it was found that anionic interferents present in blood (such as ascorbate), were effectively screened from the working electrode via a charge exclusion mechanism, in a manner similar to previous findings within our laboratory. The enzyme electrode showed an initial 32% signal drift when first exposed to whole human blood over a period of 2 hours, after which time enzyme electrode responses remained essentially stable. Whole blood patient glucose determinations yielded a correlation coefficient of r2=0.97 in comparison to standard hospital analyses.
EVI1 is consistently expressed as principal transcript in common and rare recurrent 3q26 rearrangements
Authors: Poppe Bruce , Dastugue Nicole , Vandesompele Jo , Cauwelier Barbara , De Smet Betty , Yigit Nurten , De Paepe Anne , Cervera Jose , Recher Christian , De Mas Véronique , Hagemeijer Anne , Speleman Frank 
Published: December 2005

AbstractIn contrast to the well‐documented involvement of EVI1 in various 3q26 aberrations, the transcriptional status of EVI1 in rare recurrent or sporadic 3q26 chromosomal defects has remained largely unexplored. Moreover, in a recent report, the association between 3q26 alterations in myeloid proliferations and ectopic EVI1 expression was questioned. Therefore, we performed a detailed physical mapping of 3q26 breakpoints using a 1.3‐Mb tiling path BAC contig covering the EVI1 locus and a carefully designed quantification of both EVI1 and MDS/EVI1 transcripts in 30 hematological malignancies displaying 3q26 aberrations. Cases included well‐known rare, recurring chromosomal aberrations such as t(3;17)(q26;q22), t(2;3)(p21–22;q26), and t(3;6)(q26;q25), as well as 10 new sporadic cases. Extensive 3q26 breakpoint mapping allowed unequivocal and sensitive FISH detection of EVI1 rearrangements on both metaphases and interphase nuclei. Real‐time quantitative PCR analyses indicated that typically both MDS1/EVI1 and EVI1, but not MDS1, were expressed in these malignancies, with EVI1 the primary transcript. In conclusion, we have demonstrated EVI1 involvement in numerous novel sporadic and recurrent 3q26 rearrangements. Our results underscore the feasibility of FISH as an adjunct to PCR for the identification of EVI1 deranged leukemias and identified EVI1 as the principal transcript expressed in these malignancies. © 2005 Wiley‐Liss, Inc.
Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis
Authors: Chen Jun , Kang Liang , Zhang Nian 
Published: December 2005

AbstractRecent studies show that the cyclic expression of Lfng in the presomitic mesoderm (PSM) is controlled at the transcription level by Notch signal through the CBF1 binding site for activation and periodic repression on the Lfng promoter. Here we provide genetic evidence that the oscillatory expression is controlled by a negative feedback mechanism. We also show that Hes7, another cyclically expressed protein, can bind to the N‐boxes on both Lfng and its own promoters and repress their activity. In addition, we demonstrate that the 3′ untranslated region (3′‐UTR) is important for rapid degradation of Lfng mRNA. genesis 43:196–204, 2005. © 2005 Wiley‐Liss, Inc.
Immunocytochemical analysis of D‐serine distribution in the mammalian brain reveals novel anatomical compartmentalizations in glia and neurons
Authors: Williams Susan M. , Diaz Claudia M. , Macnab Lauren T. , Sullivan Robert K.P. , Pow David V. 
Published: December 2005

AbstractD‐Serine is a co‐agonist at the NMDA receptor glycine‐binding site. Early studies have emphasized a glial localization for D‐serine. However the nature of the glial cells has not been fully resolved, because previous D‐serine antibodies needed glutaraldehyde‐fixation, precluding co‐localization with fixation‐sensitive antigens. We have raised a new D‐serine antibody optimized for formaldehyde‐fixation. Light and electron microscopic observations indicated that D‐serine was concentrated into vesicle‐like compartments in astrocytes and radial glial cells, rather than being distributed uniformly in the cytoplasm. In aged animals, patches of cortex and hippocampus were devoid of immunolabeling for D‐serine, suggesting that impaired glial modulation of forebrain glutamatergic signaling might occur. Dual immunofluorescence labeling for glutamate and D‐serine revealed D‐serine in a subset of glutamatergic neurons, particularly in brainstem regions and in the olfactory bulbs. Microglia also contain D‐serine. We suggest that some D‐serine may be derived from the periphery. Collectively, our data suggest that the cellular compartmentation and distribution of D‐serine may be more complex and extensive than previously thought and may have significant implications for our understanding of the role of D‐serine in disease states including hypoxia and schizophrenia. © 2005 Wiley‐Liss, Inc.
Clinician to frontline soldier: A look at the roles and challenges of army clinical psychologists in Iraq
Authors: Moore Bret A. , Reger Greg M. 
Published: December 2005

AbstractPsychologists have a long and respected history of service during wartime that dates back to World War I. From the early days of scientific personnel selection, clinical psychologists have made a number of wartime contributions. Today, Army clinical psychologists serving in Iraq are providing behavioral health services as both clinicians and prevention specialists in order to meet the psychological and emotional needs of service members abroad. They are also performing as Army officers and soldiers contributing to the success of military operations as a whole. The authors, two clinical psychologists and Army officers currently deployed to Iraq, provide a small glimpse into the clinical and personal opportunities and challenges faced by wartime Army clinical psychologists. © 2005 Wiley Periodicals, Inc. J Clin Psychol 62: 395–403, 2006.
Construction of the perceived parental acculturation behaviors scale
Authors: Henry Hani M. , Biran Mia W. , Stiles William B. 
Published: December 2005

AbstractThis article reports preliminary development of the Perceived Parental Acculturation Behaviors Scale (PPABS) based on a sample of 44 college students whose parents immigrated to America from Arab countries. The PPABS proposes two independent scales, whose contents characterize the respondents' perceptions of how much their parents evidence (a) openness to the American culture and (b) preservation of Arab culture. © 2005 Wiley Periodicals, Inc. J Clin Psychol 62: 293–297, 2006.
Molecular characterization and expression of maternally expressed gene 3 (Meg3/Gtl2) RNA in the mouse inner ear
Authors: Manji Shehnaaz S.M. , Sørensen Brita S. , Klockars Tuomas , Lam Timothy , Hutchison Wendy , Dahl Hans‐Henrik M. 
Published: December 2005

AbstractThe pathways responsible for sound perception in the cochlea involve the coordinated and regulated expression of hundreds of genes. By using microarray analysis, we identified several transcripts enriched in the inner ear, including the maternally expressed gene 3 (Meg3/Gtl2), an imprinted noncoding RNA. Real‐time PCR analysis demonstrated that Meg3/Gtl2 was highly expressed in the cochlea, brain, and eye. Molecular studies revealed the presence of several Meg3/Gtl2 RNA splice variants in the mouse cochlea, brain, and eye. In situ hybridizations showed intense Meg3/Gtl2 RNA staining in the nuclei of type I spiral ganglion cells and in cerebellum near the dorsal vestibular region of the cochlea. In embryonic mouse head sections, Meg3/Gtl2 RNA expression was observed in the otocyst, brain, eye, cartilage, connective tissue, and muscle. Meg3/Gtl2 RNA expression increased in the developing otocyst and localized to the spiral ganglion, stria vascularis, Reissner's membrane, and greater epithelial ridge (GER) in the cochlear duct. RT‐PCR analysis performed on cell lines derived from the organ of Corti, representing neural, supporting, and hair cells, showed significantly elevated levels of Meg3/Gtl2 expression in differentiated neural cells. We propose that Meg3/Gtl2 RNA functions as a noncoding regulatory RNA in the inner ear and that it plays a role in pattern specification and differentiation of cells during otocyst development, as well as in the maintenance of a number of terminally differentiated cochlear cell types. © 2005 Wiley‐Liss, Inc.
Micro‐Raman spectroscopy in white portland cement hydration: long‐term study at room temperature
Authors: Martinez‐Ramirez Sagrario , Frías Moisés , Domingo Concepción 
Published: December 2005

AbstractThe long‐term hydration of white portland cement has been followed through micro‐Raman spectroscopy, choosing for excitation the most adequate laser wavelength as deduced from a critical analysis of the previously reported Raman data. The bands of the corresponding spectra were attributed to the various anhydrous and hydrated phases, with full hydration of the anhydrous phases taking place after 180 days. Sulphoaluminates were seen to form in two different local environments, at 3 and 180 days respectively. Carbonates, as a secondary reaction product, were found in three different local environments. Copyright © 2005 John Wiley & Sons, Ltd.
Preparation of a monolithic column for weak cation exchange chromatography and its application in the separation of biopolymers
Authors: Wei Yinmao , Huang Xiaodong , Liu Ruixian , Shen Yehua , Geng Xindu 
Published: December 2005

AbstractA procedure for the preparation of a monolithic column for weak cation exchange chromatography was presented. The structure of the monolithic column was evaluated by mercury intrusion. The hydrodynamic and chromatographic properties of the monolithic column – such as back pressures at different flow rates, effects of pH on protein retention, dynamic loading capacity, recovery, and stability – were determined under conditions typical for ion‐exchange chromatography. The prepared monolithic column might be used in a relatively broad pH range from 4.0 to 12.0 and exhibited an excellent separation to five proteins at the flow rates of both 1.0 and 8.0 mL/min, respectively. In addition, the prepared column was first used in the purification and simultaneous renaturation of recombinant human interferon gamma (rhIFN‐γ) in the extract solution with 7.0 mol/L guanidine hydrochloride. The purity and specific bioactivity of the purified rhIFN‐γ in only one chromatographic step were obtained to be 93% and 7.8×107 IU/mg, respectively.
Allyl End‐Functionalized Poly(ethylene oxide)‐block‐poly(methylidene malonate 2.1.2) Block Copolymers: Synthesis, Characterization, and Chemical Modification
Authors: Studer Peggy , Breton Pascal , Riess Gérard 
Published: December 2005

AbstractSummary: Poly(ethylene oxide)‐block‐poly(methylidene malonate 2.1.2) block copolymer (PEO‐b‐PMM 2.1.2) bearing an allyl moiety at the poly(ethylene oxide) chain end was synthesized by sequential anionic polymerization of ethylene oxide (EO) and methylidene malonate 2.1.2 (MM 2.1.2). This allyl functional group was subsequently modified by reaction with thiol‐bearing functional groups to generate carboxyl and amino functionalized biodegradable block copolymers. These end‐group reactions, performed in good yields both in organic media and in aqueous micellar solutions, lead to functionalized PEO‐b‐PMM 2.1.2 copolymers which are of interest for cell targeting purposes.Synthetic route to α‐allyl functionalized PEO‐b‐PMM 2.1.2 copolymers.magnified imageSynthetic route to α‐allyl functionalized PEO‐b‐PMM 2.1.2 copolymers.
Combination of 2D sensitivity encoding and 2D partial fourier techniques for improved acceleration in 3D contrast‐enhanced MR angiography
Authors: Hu Houchun H. , Madhuranthakam Ananth J. , Kruger David G. , Glockner James F. , Riederer Stephen J. 
Published: December 2005

AbstractSensitivity encoding (SENSE) and partial Fourier (PF) techniques both reduce MRI acquisition time. Two‐dimensional SENSE uses coil sensitivities to unfold aliasing in the phase/slice‐encoding plane. One‐dimensional PF and homodyne reconstruction are routinely applied in the frequency/phase‐encoding plane to compensate for nonsampled k‐space of the presumed real magnetization. Recently, a modified 3D elliptical centric acquisition was proposed to facilitate 2D‐PF and homodyne reconstruction on an undersampled phase/slice‐encoding plane. In this work we hypothesized that this 2D‐PF technique can be combined with 2D‐SENSE to achieve a greater acceleration factor than what each method can provide separately. Reconstruction of data whereby SENSE and PF are applied along the same axes is described. Contrast‐enhanced MR angiography (CE‐MRA) results from experiments using four receiver coils in phantom and volunteer studies are shown. In 11 volunteer studies, the SENSE‐PF‐homodyne technique using sevenfold acceleration (4× SENSE, 1.7× PF) consistently provided high‐diagnostic‐quality images with near 1‐mm isotropic resolution in acquisition times of <20 s. Magn Reson Med, 2006. © 2005 Wiley‐Liss, Inc.