bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of endoscopic sinus surgery in management of odontogenic maxillary sinusitis after control of dental pathology
Authors: Aljeraisi Talal 
Published: April 2024

Abstract
Background
Odontogenic sinusitis (ODS) has clinical features like rhinogenic sinusitis. Although it is usually unilateral, diagnostic overlap could happen. However, ODS necessitates different management which includes dental intervention to eliminate the dental infection source. In some patients, ODS may persist even after management of dental pathology. The aim of this study was to assess the clinical features, and diagnostic criteria of ODS that is persistent after management of dental pathology, and to evaluate the efficacy of endoscopic sinus surgery (ESS) as a therapeutic option of the disease.

Methods
Twenty patients were included in this study. All patients were presented with ODS refractory to medical treatment after management of their dental problems. Clinical features of the patients were analyzed. Also, endoscopic nasal examination and computed tomography of paranasal sinuses (CT) were performed for all patients. ESS were used, with widening of the maxillary ostium for drainage. Follow-up was carried out for at least 6 months.

Results
All patients had unilateral disease, with 3 main complaints: malodourous nasal discharge (90%), facial pain (75%), and nasal obstruction (45%). Endoscopic nasal examination showed either middle meatal purulence (70%) or polypoid mucosa (30%). CT showed either thickened maxillary sinus mucosa (50%), or complete maxillary opacity (50%) with retained foreign body in 2 patients (10%). After ESS, all patients reported relieve of their sinonasal symptoms, and nasal endoscopy showed patent middle meatus, with one patient demonstrated adhesions between the middle turbinate and lateral nasal wall which was asymptomatic.

Conclusion
Prior dental intervention is a suspicious diagnostic landmark for ODS, and unilateral foul nasal discharge is the main prevalent complaint. Nasal endoscopy usually shows purulence or polypoid mucosa in the middle meatus, and CT is a good diagnostic tool for ODS. ESS with good widening of the maxillary ostium is an effective therapeutic option for those patients.
Clinical translation of pluripotent stem cell-based therapies: successes and challenges
Authors: Christiansen Josefine Rågård , Kirkeby Agnete 
Published: April 2024

ABSTRACT
The translational stem cell research field has progressed immensely in the past decade. Development and refinement of differentiation protocols now allows the generation of a range of cell types, such as pancreatic β-cells and dopaminergic neurons, from human pluripotent stem cells (hPSCs) in an efficient and good manufacturing practice-compliant fashion. This has led to the initiation of several clinical trials using hPSC-derived cells to replace lost or dysfunctional cells, demonstrating evidence of both safety and efficacy. Here, we highlight successes from some of the hPSC-based trials reporting early signs of efficacy and discuss common challenges in clinical translation of cell therapies.
Nuclear actin dynamics and functions at a glance
Authors: Ulferts Svenja , Lopes Massimo , Miyamoto Kei , Grosse Robert 
Published: April 2024

ABSTRACT
Actin is well known for its cytoskeletal functions, where it helps to control and maintain cell shape and architecture, as well as regulating cell migration and intracellular cargo transport, among others. However, actin is also prevalent in the nucleus, where genome-regulating roles have been described, including it being part of chromatin-remodeling complexes. More recently, with the help of advances in microscopy techniques and specialized imaging probes, direct visualization of nuclear actin filament dynamics has helped elucidate new roles for nuclear actin, such as in cell cycle regulation, DNA replication and repair, chromatin organization and transcriptional condensate formation. In this Cell Science at a Glance article, we summarize the known signaling events driving the dynamic assembly of actin into filaments of various structures within the nuclear compartment for essential genome functions. Additionally, we highlight the physiological role of nuclear F-actin in meiosis and early embryonic development.
The cultural sector in Polish economy in the regional approach
Authors: Stanowicka Agnieszka , Kobylińska Małgorzata 
Published: April 2024

Motivation: In recent years, the impact of cultural factors on the economic development has been analysed. This research concerns the impact of culture on the labour market, the growth of innovation and creativity, participation in creating added value of GDP, stimulating exports, although the cultural sector also affects the development of tourism, entertainment and improvement in the quality of life of residents. Currently, the cultural sector is treated as a long-term economic investment affecting the development of the country.Aim: The goal of the article is to evaluate the functioning of the cultural sector in Poland. This assessment has been made on a regional basis.Results: To achieve the purpose, data of the GUS (Central Statistical Office in Poland) were analysed. The data concerned expenses allocated to culture and national heritage — they included individual types of cultural institutions and number of cultural sector entities in 2018–2021. The results of the analysis of the cultural sector have been presented in tables and diagrams. Using an agglomeration method, the Polish provinces were grouped according to values of the analysed categories of expenses allocated to culture and national heritage in the provinces in year 2021. It was noticed that the development of the cultural sector in Poland is uneven, concentrated in the country’s capital, which is typical for less developed countries. Therefore, main barriers to the development of the cultural sector in Poland were identified. The most important obstacles were: underfunding, lack of systemic solutions to support the demand for cultural goods, unfavourable legal and financial conditions for creators of culture, lack of support for cooperation between public and private cultural sector, dependence of the development of the cultural sector on politics, as well as lack of social acceptance of the cultural policy. Culture is also negatively affected by the processes of globalization, commercialization and recently the Covid 19 pandemic.
Simple and Explicit Bounds for Multiserver Queues with 11−ρ Scaling
Authors: Li Yuan , Goldberg David A. 
Published: April 2024

We consider the first-come-first-serve (FCFS) [Formula: see text] queue and prove the first simple and explicit bounds that scale as [Formula: see text] under only the assumption that interarrival times have finite second moment, and service times have finite [Formula: see text] moment for some [Formula: see text]. Here, ρ denotes the corresponding traffic intensity. Conceptually, our results can be viewed as a multiserver analogue of Kingman’s bound. Our main results are bounds for the tail of the steady-state queue length and the steady-state probability of delay. The strength of our bounds (e.g., in the form of tail decay rate) is a function of how many moments of the service distribution are assumed finite. Our bounds scale gracefully, even when the number of servers grows large and the traffic intensity converges to unity simultaneously, as in the Halfin-Whitt scaling regime. Some of our bounds scale better than [Formula: see text] in certain asymptotic regimes. In these same asymptotic regimes, we also prove bounds for the tail of the steady-state number in service. Our main proofs proceed by explicitly analyzing the bounding process that arises in the stochastic comparison bounds of Gamarnik and Goldberg for multiserver queues. Along the way, we derive several novel results for suprema of random walks and pooled renewal processes, which may be of independent interest. We also prove several additional bounds using drift arguments (which have much smaller prefactors) and point out a conjecture that would imply further related bounds and generalizations. We also show that when all moments of the service distribution are finite and satisfy a mild growth rate assumption, our bounds can be strengthened to yield explicit tail estimates decaying as [Formula: see text], with [Formula: see text], depending on the growth rate of these moments.Funding: Financial support from the National Science Foundation [Grant 1333457] is gratefully acknowledged.Supplemental Material: The supplemental appendix is available at https://doi.org/10.1287/moor.2022.0131 .
Cellular angiofibroma arising from the rectocutaneous fistula in an adult: A case report
Authors: Chen Hao-En , Lu Yu-Yang , Su Ruei-Yu , Wang Hong-Hau , Chen Chao-Yang , Hu Je-Ming , Kang Jung-Cheng , Lin Kuan-Hsun , Pu Ta-Wei 
Published: April 2024

BACKGROUND
Rectocutaneous fistulae are common. The infection originates within the anal glands and subsequently extends into adjacent regions, ultimately resulting in fistula development. Cellular angiofibroma (CAF), also known as an angiomyofibroblastoma-like tumor, is a rare benign soft tissue neoplasm predominantly observed in the scrotum, perineum, and inguinal area in males and in the vulva in females. We describe the first documented case CAF that developed within a rectocutaneous fistula and manifested as a perineal mass.
CASE SUMMARY
In the outpatient setting, a 52-year-old male patient presented with a 2-year history of a growing perineal mass, accompanied by throbbing pain and minor scrotal abrasion. Physical examination revealed a soft, well-defined, non-tender mass at the left buttock that extended towards the perineum, without a visible opening. The initial assessment identified a soft tissue tumor, and the laboratory data were within normal ranges. Abdominal and pelvic computed tomography (CT) revealed swelling of the abscess cavity that was linked to a rectal cutaneous fistula, with a track-like lesion measuring 6 cm × 0.7 cm in the left perineal region and attached to the left rectum. Rectoscope examination found no significant inner orifices. A left medial gluteal incision revealed a thick-walled mass, which was excised along with the extending tract, and curettage was performed. Histopathological examination confirmed CAF diagnosis. The patient achieved total resolution during follow-up assessments and did not require additional hospitalization.
CONCLUSION
CT imaging supports perineal lesion diagnosis and management. Perineal angiofibromas, even with a cutaneous fistula, can be excised transperineally.
Subdural effusion associated with COVID-19 encephalopathy: A case report
Authors: Xue Zhi-Yuan , Xiao Zhong-Lin , Cheng Ming , Xiang Tao , Wu Xiao-Li , Ai Qiao-Ling , Wu Yang-Ling , Yang Tao 
Published: April 2024

BACKGROUND
The precise mechanism by which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) impacts the central nervous system remains unclear, with manifestations spanning from mild symptoms (e.g., olfactory and gustatory deficits, hallucinations, and headache) to severe complications (e.g., stroke, seizures, encephalitis, and neurally demyelinating lesions). The occurrence of single-pass subdural effusion, as described below, is extremely rare.
CASE SUMMARY
A 56-year-old male patient presented with left-sided limb weakness and slurred speech as predominant clinical symptoms. Through comprehensive imaging and diagnostic assessments, he was diagnosed with cerebral infarction complicated by hemorrhagic transformation affecting the right frontal, temporal, and parietal regions. In addition, an intracranial infection with SARS-CoV-2 was identified during the rehabilitation process; consequently, an idiopathic subdural effusion developed. Remarkably, the subdural effusion underwent absorption within 6 d, with no recurrence observed during the 3-month follow-up.
CONCLUSION
Subdural effusion is a potentially rare intracranial complication associated with SARS-CoV-2 infection.
Idiopathic mesenteric phlebosclerosis missed by a radiologist at initial diagnosis: A case report
Authors: Wang Min , Wan Yu-Xia , Liao Jin-Wen , Xiong Fei 
Published: April 2024

BACKGROUND
Idiopathic mesenteric phlebosclerosis (IMP) is a rare type of ischemic colitis characterized by thickening of the wall of the right hemicolon and calcification, sclerosis, and fibrosis of mesenteric veins. The diagnosis of IMP is based on typical clinical features and imaging findings. We report a case of IMP that was initially missed by the radiologist.
CASE SUMMARY
A 77-year-old woman was admitted to the hospital due to chronic diarrhea for over 2 months. She had been consuming Chinese patent medicines (CPM) containing fructus gardeniae for more than 15 years. Colonoscopy revealed an edematous mucosa, bluish-purple discoloration, erosions, and ulcerations throughout the colorectal area. Abdominal computed tomography (CT) showed diffuse mural thickening of the entire colorectum, with tortuous thread-like calcifications in the right hemicolon, left hemicolon, and rectum. Most of the calcifications were located in the mesenteric vein. The diagnosis of IMP was established based on medical history, colonoscopy, CT findings, and histopathological examination. The patient was treated conservatively with papaverine and rifaximin, and CPM was stopped. Her diarrhea symptoms improved, indicating the effectiveness of the treatment. Over the next several years, she took opium alkaloids for an extended period and did not require hospitalization for the aforementioned gastrointestinal disorder.
CONCLUSION
IMP is a rare gastrointestinal disease affecting Asian populations, possibly related to long-term herbal medicine intake. Accurate imaging analysis is crucial for diagnosis, but insufficient understanding of the disease can lead to misdiagnosis or missed diagnosis. Treatment strategies should be personalized.
Panhypopituitarism caused by a suprasellar germinoma: A case report
Authors: Roganovic Jelena , Saric Lea , Segulja Silvije , Dordevic Ana , Radosevic Mia 
Published: April 2024

BACKGROUND
Suprasellar germinomas are rare intracranial tumors frequently associated with permanent endocrine disorders. We present the clinical picture, treatment, and complications of suprasellar germinoma at pediatric age which, besides being life-threatening, has lifelong endocrinological consequences.
CASE SUMMARY
A 12-year-old female patient was presented having had intensive headaches for three weeks and visual disturbances for six months. An ophthalmological examination revealed bilateral papilledema and a marked loss of vision. Emergency brain magnetic resonance imaging (MRI) showed a suprasellar tumor, involving the infundibulum and the optic chiasm, extending to the third ventricle. Laboratory tests confirmed decreased levels of thyroxine, cortisol, gonadotropins, and insulin-like growth factor 1. Maximal tumor reduction was performed, and immunohistopathology established the diagnosis of suprasellar germinoma. MRI of the spine and cerebrospinal fluid cytology confirmed the localized disease. Adjuvant chemotherapy and radiotherapy were performed according to the SIOP CNS GCT II protocol. A post-treatment MRI showed no residual tumor, but pituitary function had not recovered. Three and a half years after the end of the treatment, the patient is in a complete remission, requiring hormonal replacement therapy, continuous education, and psychological support.
CONCLUSION
This complex case highlights the importance of timely diagnosis, a multidisciplinary approach, and close follow-up in children with suprasellar germinomas.
Effectiveness of telerehabilitation based on real-time intervention between therapist and participants for improving physical function, activities of daily living and quality of life in people with stroke: A systematic review protocol
Authors: Fujii Ren , Miki Takahiro , Nonaka Yuki , Tanaka Shinichiro 
Published: April 2024

Background
There is a call for gathering more evidence on the effectiveness of telerehabilitation in stroke. In particular, a previous systematic review reported substantial variability in the types of technologies used in telerehabilitation interventions. The purpose of this study will be to summarize and synthesize findings on the effects of telerehabilitation based on real-time intervention between therapist and participants for patients with stroke.

Methods and analysis
This systematic review will follow the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) statement. This systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) on 25 May 2023 (registration number: CRD420234265527). Electronic searches will be performed in the following databases: MEDLINE, Pubmed, Web of Science, PsycINFO and CINAHL electronic databases, using a date range from inception to November 2023. We will include only randomized controlled trials for patients diagnosed with stroke who received telerehabilitation based on real-time interaction between therapist and patients. The exploration will be restricted to publications in the English language. Physical function, activities of daily living and quality of life are the outcomes. We will examine the changes of the outcomes at baseline, at the end of the intervention, and at specific time points during the follow-up after the intervention.

Discussion
This systematic review will provide evidence regarding telerehabilitation for people with stroke.
EFEKTIVITAS PEMBERIAN SOAL TIPE HOTS TERHADAP KEMAMPUAN PEMECAHAN MASALAH SISWA
Authors: Istiqlal Muhammad , Habib Muhamad Nur 
Published: April 2024

Tujuan penelitian ini adalah untuk mengetahui efektivitas pemberian soal tipe HOTS terhadap kemampuan pemecahan masalah pada siswa kelas VII MTs SA Al-Idrus Repaking Wonosamodro Boyolali Tahun Pelajaran 2020/2021. Penelitian ini menggunakan metode penelitian Kuantitatif. Populasi dalam penelitian ini ada 2 yaitu siswa kelas VII A dan kelas VII B yang berjumlah masing-masing 20 siswa. Sampel dalam penelitian ini adalah 20 siswa kelas VII A sebagai kelas Eksperimen dan 20 siswa kelas VII B sebagai kelas kontrol. Teknik pemilihan sampel dengan menggunakan metode sampel jenuh. Uji prasyarat terdiri dari Uji Homogenitas dan Uji Normalitas. Teknik analisis yang digunakan dalam penelitian ini adalah uji-t untuk menguji secara parsial dan uji-F untuk menguji variabel secara Bersama-sama. Hasil analsis dari penelitian ini diperoleh thitung = 3,564 dan ttabel = 2,025. Hal ini menunjukkan bahwa thitung > ttabel, maka H0 ditolak dan H1 diterima yang berarti bahwa terdapat perbedaan yang signifikan antara kemampuan pemecahan masalah siswa kelas eksperimen dengan siswa kelas kontrol, dengan kata lain pemberian soal tipe HOTS efektif digunakan dalam pembelajaran matematika pokok himpunan. Hal ini juga dapat dilihat dari nilai rata-rata post tes siswa kelas eksperimen yaitu sebesar 78,75 lebih besar dari nilai siswa kelas kontrol yang hanya memperoleh nilai rata-rata 66,75.
Hubungan Antara Kemandirian Belajar dengan Disposisi Matematis Peserta Didik Kelas X Sekolah Menengah Atas (SMA)
Authors: Maghfiroh Az Zahra Sayidatul , Izzah Aqidatul 
Published: April 2024

Kemandirian belajar merupakan inisiatif peserta didik secara mandiri dalam belajar yang menjadi aspek penting untuk menunjang keberhasilan peserta didik dalam proses pembelajaran. Selain kemandirian belajar, disposisi matematis juga perlu dimiliki oleh peserta didik agar mampu bertanggung jawab dalam belajar dan menerapkan kebiasaan bekerja dengan baik dalam matematika, serta menyelesaikan persoalan dengan sistematis. Penelitian ini bertujuan untuk mengetahui hubungan antara kemandirian belajar dengan disposisi matematis peserta didik kelas X di salah satu SMA negeri di Kota Serang. Metode penelitian yang digunakan yaitu metode penelitian kuantitatif dengan teknik penelitian keterkaitan atau korelasi. Sampel pada penelitian ini berjumlah 31 peserta didik kelas X. Teknik pengambilan data menggunakan instrumen nontes berupa kuisioner kemandirian belajar dan disposisi matematis yang telah diuji validitas dan reliabilitasnya serta disebarkan melalui google formulir. Hasil penelitian menunjukkan bahwa nilai korelasi antara kemandirian belajar dengan disposisi matematis dalam tingkat kategori sangat rendah yaitu sebesar 0.091. Adapun nilai signifikansi yang dihitung dengan SPSS versi 25.0 sebesar 0.626 0.05 yang berarti tidak terdapat hubungan secara signifikan antara kemandirian belajar dengan dipsosisi matematis peserta didik. Hal tersebut dikarenakan banyak faktor lain yang berpengaruh dalam aspek disposisi matematis.
PENGARUH TAMBAHAN SERAT SABUT KELAPA TERHADAP KUAT TEKAN DAN KUAT TARIK BELAH BETON
Authors: Prayogi Galih 
Published: April 2024

Beton ternyata memiliki kelemahan terhadap gaya tarik. Salah satu cara untuk memperbaiki kelemahan beton dalam kuat tarik adalah dengan penambahan serat pada adukan beton yang disebut beton serat. Penelitian ini adalah untuk mengetahui kuat tekan dan kuat tarik belah beton normal dengan penambahan serat sabut kelapa umur 7 hari, 14 hari dan 28 hari. Besarnya persentase penambahan serat sabut kelapa adalah 0,5%; 2,5%; 4,5%; 6,5%; dan 8,5% terhadap volume total beton. Pengujian kuat tekan dan kuat tarik belah beton menggunakan sampel silinder dengan diameter 10 cm dan tinggi 20 cm. Serat berupa sabut kelapa yang digunakan dengan panjang 30 mm. Nilai kuat tekan beton tanpa penambahan serat pada umur 28 hari sebesar 31,33 MPa, sedangkan beton dengan penambahan 0,5%; 2,5%; 4,5%; 6,5%; dan 8,5% serat sabut kelapa memperoleh nilai kuat tekan berturut-turut sebesar 33,05 MPa; 33,72 MPa; 24,46 MPa; 16,47 MPa; dan 9,23 MPa. Nilai kuat tarik belah beton tanpa penambahan serat pada umur 28 hari sebesar 2,835 MPa, sedangkan beton dengan penambahan 0,5%; 2,5%; 4,5%; 6,5%; dan 8,5% serat sabut kelapa memperoleh nilai kuat tarik belah berturut-turut sebesar 3,497 MPa; 3,754 MPa; 4,029 MPa; 3,345 MPa; dan 3,039 MPa, sedangkan nilai kuat tekan maksimum terjadi pada beton variasi 2,5% dengan penambahan serat sabut kelapa yaitu sebesar 33,05 MPa, sedangkan nilai kuat tarik belah maksimum terjadi pada beton variasi 4,5% dengan penambahan serat sabut kelapa yaitu sebesar 4,029 MPa. Hasil persamaan kuat tarik belah berdasarkan nilai kuat tekan beton pada persentase 0% mendapat 0,507√f'c sedangkan pada beton penambahan serat serabut kelapa pada 0,5%; 2,5%; 4,5%; 6,5%; dan 8,5% bertutur-turut sebesar 0,608√f'c; 0,646√f'c; 0,815√f'c 0,824√f'c 1,0004√f'c Kata kunci: beton serat, serat sabut kelapa, kuat tekan, kuat tarik belah