bluuebunny/crossref_metadata_2025_split huggingface dataset:
Homotherapy for heteropathy: Interleukin‐41 and its biological functions
Authors: Shi Runfeng , He Meixin , Peng Yongzheng , Xia Xu 
Published: April 2024

AbstractInterleukin‐41 (IL‐41) is a newly discovered cytokine, named Cometin, Subfatin, meteorin‐like transcription (Metrnl), and so forth. It is widely expressed in animals and can exert its biological roles through autocrine and paracrine forms. It has functions such as anti‐inflammatory, improving body metabolism, regulating immunity, regulating fat metabolism and participates in the process of autoimmune disease or inflammatory injury. It plays an important role in psoriasis, diabetes, Crohn's disease (CD), osteoarthritis, Kawasaki disease (KD), Graves' disease, autoimmune hepatitis, infertility, obesity, sepsis, cardiovascular diseases and respiratory diseases. This paper reviews the biological functions of IL‐41, the relationship between IL‐41 and diseases, the effects of IL‐41 in the cytokine network and the possible signalling pathways. In order to explore the same target or the same drug for the treatment of different diseases from the perspective of homotherapy for heteropathy, cytokine strategies based on IL‐41 have been put forward for the precise treatment of immune diseases and inflammatory diseases. It is worth noting that IL‐41 related preparations for lung protection and smoking cessation are interesting research fields.
Ultrafast discharge properties and enhanced energy density in lead‐free NaNbO3‐based relaxor ferroelectric ceramics
Authors: Yuan Liran , Fu Shuai , Hao Hua , Meng Xiangyu , Cao Minghe , Yao Zhonghua , Liu Hanxin 
Published: April 2024

AbstractNaNbO3‐based (NN) energy storage ceramics are known for exhibiting high maximum polarization (Pmax) and large recoverable energy density (Wrec). However, the huge energy loss density (Wloss) has been a limiting factor in improving energy storage performance. Therefore, a ternary system was designed to achieve both huge Wrec and efficiency (η). The combination of 0.35Bi(Zn0.5Ti0.5)O3–0.65BaTiO3 (BZTBT) was chosen to reduce grain size and disrupt the long‐range ordered domains, thereby inducing the polar‐nano‐regions to mitigate Wloss. The optimal performance was achieved with the 0.75NaNbO3–0.25(0.35Bi(Zn0.5Ti0.5)O3–0.65BaTiO3) (0.75NN–0.25BZTBT) ceramic, which exhibited a high Wrec = 2.68 J/cm3 and superior η = 82.7% under 310 kV/cm. Remarkably, the 0.75NN–0.25BZTBT ceramic displayed an exceptionally fast discharge time to 90%, t0.9 = 88 ns, coupled with a huge energy density Wd = 0.95 J/cm3. This study demonstrates the significant potential of 0.75NN–0.25BZTBT ceramic in the realm of energy storage and rapid charge–discharge applications.
Dermatological manifestations in Costello syndrome: A prospective multicentric study of 31 HRAS‐positive variant patients
Authors: Bessis Didier , Bursztejn Anne‐Claire , Morice‐Picard Fanny , Capri Yline , Barbarot Sébastien , Aubert Hélène , Bodet Damien , Bourrat Emmanuelle , Chiaverini Christine , Poujade Laura , Willems Marjolaine , Rouanet Jacques , Dompmartin‐Blanchère Anne , Geneviève David , Gerard Marion , Ginglinger Emmanuelle , Hadj‐Rabia Smaïl , Martin Ludovic , Mazereeuw‐Hautier Juliette , Bibas Nathalie , Molinari Nicolas , Herman Fanchon , Phan Alice , Rod Julien , Roger Hugues , Sigaudy Sabine , Ziegler Alban , Vial Yoann , Verloes Alain , Cavé Hélène , Lacombe Didier 
Published: April 2024

AbstractBackgroundData on dermatological manifestations of Costello syndrome (CS) remain heterogeneous and lack in validated description.ObjectivesTo describe the dermatological manifestations of CS; compare them with the literature findings; assess those discriminating CS from other RASopathies, including cardiofaciocutaneous syndrome (CFCS) and the main types of Noonan syndrome (NS); and test for dermatological phenotype–genotype correlations.MethodsWe performed a 10‐year, large, prospective, multicentric, collaborative dermatological and genetic study.ResultsThirty‐one patients were enrolled. Hair abnormalities were ubiquitous, including wavy or curly hair and excessive eyebrows, respectively in 68% and 56%. Acral excessive skin (AES), papillomas and keratotic papules (PKP), acanthosis nigricans (AN), palmoplantar hyperkeratosis (PPHK) and ‘cobblestone’ papillomatous papules of the upper lip (CPPUL), were noted respectively in 84%, 61%, 65%, 55% and 32%. Excessive eyebrows, PKP, AN, CCPUL and AES best differentiated CS from CFCS and NS. Multiple melanocytic naevi (>50) may constitute a new marker of attenuated CS associated with intragenic duplication in HRAS. Oral acitretin may be highly beneficial for therapeutic management of PPHK. No significant dermatological phenotype–genotype correlation was determined between patients with and without HRAS c.34G>A (p.G12S).Conclusions and RelevanceThis validated phenotypic characterization of a large number of patients with CS will allow future researchers to make a positive diagnosis, and to differentiate CS from CFCS and NS.
Discrepancies in hidradenitis suppurativa lesion characterization by providers and patients
Authors: Greenlund Lindsey , Herzog Claire , Wendland Zachary , Rypka Katelyn , Frew John W. , Kirby Joslyn S. , Alavi Afsaneh , Khalid Bisma , Lowes Michelle A. , Garg Amit , Marzano Angelo V. , Zouboulis Christos C. , Tzellos Thrasyvoulos , Jaleel Tarannum , Goldfarb Noah 
Published: April 2024

AbstractBackgroundThe hidradenitis suppurativa (HS) clinical response (HiSCR) has come under scrutiny as several HS clinical trials failed to meet primary endpoints with high placebo responses. This may be due to limitations of the tool and raters' ability to accurately characterize and count lesions, rather than lack of efficacy of the studied drug. Due to HS lesion complexity and potential differences in rater training, it was hypothesized that there would be discrepancies in how providers characterize and count lesions for HS clinical trials.ObjectiveTo evaluate how HS providers and patients name and count HS lesions and to identify discrepancies among providers to initiate the development of consensus‐driven guidance for HS rater training.MethodsAn online survey was distributed to the members of HIdradenitis SuppuraTiva cORe outcomes set International Collaboration (HISTORIC). Respondents were asked to classify lesion images composed of multiple and different morphology types and answer questions regarding inclusion of associated dermatological conditions.ResultsForty‐seven HISTORIC members responded (29 providers; 18 patients). There was variability in how respondents classified HS lesions. Of 12 questions containing images, four had ≥50% of respondents choosing the same answer. With an image of a lesion composed of different morphologies, 45% of providers counted it as a single lesion and 45% counted it as multiple distinct lesions. With an image of multiple interconnected draining tunnels, 7% of providers classified it as a single draining tunnel while 79% categorized it as multiple draining tunnels with the number estimated by visual inspection. There was also variability in deciding whether lesions occurring in associated conditions should be considered separately or included in HS lesion counts. Patient responses were also variable.ConclusionsThe result of the current study reaffirms the gap in how providers characterize and count HS lesions for clinical trials and the need to develop consensus‐driven rater training related to HS outcome measures.
The combined exposure of polystyrene microplastics and high‐fat feeding affects the intestinal pathology damage and microbiome in zebrafish
Authors: Huang Peng , Hu Yanqiu , Zhang Xiankai , Zhou Jingyi , Xiao Han , Du Juan 
Published: April 2024

AbstractThe pervasive utilization of plastics and their integration into ecosystems has resulted in significant environmental issues, particularly the pollution of microplastics (MPs). In aquaculture, high‐fat feed (HFD) is frequently employed to enhance the energy intake and economic fish production. This study utilized zebrafish as a model organism to investigate the impact of concurrent exposure to HFD and MPs on fish intestinal pathology damage and intestinal microbiome. The experimental design involved the division of zebrafish into two groups: one receiving a normal diet (ND) and the other receiving HFD. The zebrafish were exposed to a control group, as well as polystyrene (PS) MPs of varying sizes (5 and 50 μm). Histopathological examination revealed that the combination of 5 μm MPs and HFD resulted in the most significant damage to the zebrafish intestinal tract. Furthermore, gut microbiome assays indicated that exposure to MPs and HFD altered the composition of the gut microbiome. This study demonstrates that in aquaculture, the issue of HFD must be considered alongside concerns about MPs contamination, as both factors appear to have a combined effect on the intestinal pathology damage and intestinal microbiome. The findings of this research offer valuable insights for the improvement of fish farming practices.
Recruitment dynamics of juvenile salmonids: Comparisons among populations and with classic case studies
Authors: Matte Jean‐Michel O. , Fraser Dylan J. , Grant James W. A. 
Published: April 2024

AbstractUnderstanding recruitment, the process by which individuals are added to a population or to a fishery, is critical for understanding population dynamics and facilitating sustainable fisheries management. Important variation in recruitment dynamics is observed among populations, wherein some populations exhibit asymptotic productivity and others exhibit overcompensation (i.e., compensatory density‐dependence in recruitment). Our ability to understand this interpopulation variability in recruitment patterns is limited by a poor understanding of the underlying mechanisms, such as the complex interactions between density dependence, recruitment, and environment. Furthermore, most studies on recruitment are conducted using an observational design with long time series that are seldom replicated across populations in an experimentally controlled fashion. Without proper replication, extrapolations between populations are tenuous, and the underlying environmental trends are challenging to quantify. To address these issues, we conducted a field experiment manipulating stocking densities of juvenile brook trout Salvelinus fontinalis in three wild populations to show that these neighboring populations—which exhibit divergent patterns of density dependence due to environmental conditions—also have important differences in recruitment dynamics. Testing against four stock‐recruitment models (density independent, linear, Beverton‐Holt, and Ricker), populations exhibited ~twofold variation in asymptotic productivity, with no overcompensation following a Beverton‐Holt model. Although environmental variables (e.g., temperature, pH, depth, substrate) correlated with population differences in recruitment, they did not improve the predictive power in individual populations. Comparing our patterns of recruitment with classic salmonid case studies revealed that despite differences in the shape and parameters of the curves (i.e., Ricker vs. Beverton‐Holt), a maximum stocking density of about five YOY fish/m2 emerged. Higher densities resulted in very marginal increases in recruitment (Beverton‐Holt) or reduced recruitment due to overcompensation (Ricker).
Using interoperable nursing care data to improve outcomes for multiple traumas patients with Impaired Physical Mobility
Authors: Camilo Ferreira Raisa , Dunn‐Lopez Karen , Moorhead Sue , Zuchatti Bruna Valentina , Pereira Paula Cristina , M Duran Erika Christianne 
Published: April 2024

AbstractAim(s)To demonstrate how interoperable nursing care data can be used by nurses to create a more holistic understanding of the healthcare needs of multiple traumas patients with Impaired Physical Mobility. By proposing and validating linkages for the nursing diagnosis of Impaired Physical Mobility in multiple trauma patients by mapping to the Nursing Outcomes Classification (NOC) and Nursing Interventions Classification (NIC) equivalent terms using free‐text nursing documentation.DesignA descriptive cross‐sectional design, combining quantitative analysis of interoperable data sets and the Kappa's coefficient score with qualitative insights from cross‐mapping methodology and nursing professionals' consensus.MethodsCross‐mapping methodology was conducted in a Brazilian Level 1 Trauma Center using de‐identified records of adult patients with a confirmed medical diagnosis of multiple traumas and Impaired Physical Mobility (a nursing diagnosis). The hospital nursing free‐text records were mapped to NANDA‐I, NIC, NOC and NNN linkages were identified. The data records were retrieved for admissions from September to October 2020 and involved medical and nursing records. Three expert nurses evaluated the cross‐mapping and linkage results using a 4‐point Likert‐type scale and Kappa's coefficient.ResultsThe de‐identified records of 44 patients were evaluated and then were mapped to three NOCs related to nurses care planning: (0001) Endurance; (0204) Immobility Consequences: Physiological, and (0208) Mobility and 13 interventions and 32 interrelated activities: (6486) Environmental Management: Safety; (0840) Positioning; (3200) Aspiration Precautions; (1400) Pain Management; (0940) Traction/Immobilization Care; (3540) Pressure Ulcer Prevention; (3584) Skincare: Topical Treatment; (1100) Nutrition Management; (3660) Wound Care; (1804) Self‐Care Assistance: Toileting; (1801) Self‐Care Assistance: Bathing/Hygiene; (4130) Fluid Monitoring; and (4200) Intravenous Therapy. The final version of the constructed NNN Linkages identified 37 NOCs and 41 NICs.ConclusionThese valid NNN linkages for patients with multiple traumas can serve as a valuable resource that enables nurses, who face multiple time constraints, to make informed decisions efficiently. This approach of using evidence‐based linkages like the one developed in this research holds high potential for improving patient's safety and outcomes.No Patient or Public ContributionIn this study, there was no direct involvement of patients, service users, caregivers or public members in the design, conduct, analysis and interpretation of data or preparation of the manuscript. The study focused solely on analysing existing de‐identified medical and nursing records to propose and validate linkages for nursing diagnoses.
Reducing unwarranted chest x‐rays in bronchiolitis: Importance of a robust analysis
Authors: Lawrence Joanna , Hiscock Harriet , Voskoboynik Alice , Walpola Ramesh , Sharma Anurag 
Published: April 2024

AimBronchiolitis is the commonest reason for hospitalisation amongst infants and is often a target for low‐value care (LVC) reduction. We aimed to assess the impact of a multifaceted intervention (clinician education, parent engagement, audit‐feedback) on rates of chest x‐rays (CXR) in bronchiolitis.MethodsLongitudinal study of CXRs ordered in infants (1–12 months) diagnosed with bronchiolitis in the Emergency Department (ED) of an Australian paediatric hospital between May 2016 and February 2023. We used logistic regression to measure the impact of the intervention on unwarranted CXR orders, controlling for other potential impacting variables such as time, patient characteristics (age/sex), clinical variables (fever, hypoxia, tachypnoea), seasonal factors (month, day of the week, business hours) and time passed since intervention.ResultsTen thousand one hundred and nine infants were diagnosed with bronchiolitis in the ED over the study period, with 939 (9.3%) receiving a CXR, of which 69% (n = 651) were considered unwarranted. Rates of unwarranted CXRs reduced from 7.9% to 5.4% post‐intervention (P < 0.0001). Logistic regression showed the intervention had no significant effect (OR 0.89, 95% CI 0.65–1.23) once other variables and underlying time‐based trends were accounted for.ConclusionsAlthough pre‐post rates appeared significantly improved, a robust analysis demonstrated that our multi‐faceted intervention was not effective in reducing CXRs in bronchiolitis. The decision to order CXR was associated with clinical features that overlap with pneumonia suggesting ongoing misconceptions regarding the role of CXR for this indication. Our study highlights the value of large electronic medical record datasets and robust methodology to avoid falsely attributing underlying trends to the LVC intervention.
The impact of incorporating dried cafeteria leftover food on growing APRI rabbits productivity, profitability and meat quality
Authors: Hassanein Hanan A. M. , Morsy Shama H. , Phillip Youssef L. , Abdelmagid Marwa A. , Komonna Osama F. , Mohamed Rehab A. , Fouda Doaa A. S. , Hegazy Nahed M. , Hussein Ahmed M. , Radwan Mohamed A. 
Published: April 2024

AbstractThis study was conducted to investigate the effect of dried cafeteria leftover food (DCLF) incorporation in growing APRI rabbit diets on nutrient digestibility, live body weight, body weight gain, carcass traits, meat quality, blood parameters, and economic efficiency. Thirty‐six APRI rabbits (6 weeks of age), after weaning, were randomly divided into three groups (12 rabbits/group, 613 ± 5 g). During the experiment, rabbits aged 6–14 weeks participated in the experiment. An approximate isocaloric and isonitrogenous composition was achieved in three pelleted experimental diets. For the rabbit groups D1 (as the control), D2, and D3, DCLF was added at doses of 0%, 17.5%, and 35%, respectively. Digestibility trails were carried out at the end of the feeding experiment to evaluate the nutritional and feeding values of the experimental diets. To examine the characteristics of the carcasses, the quality of the meat, the histopathological analysis, and the blood plasma parameters, three rabbits were slaughtered from each group. The results showed that the feeding values (TDN and DE), which had the greatest values, as well as the digesting coefficients for dry matter, organic matter, crude fiber, and ether extract between the D1 and D3 groups were significantly different (p < 0.05). On the contrary, the curde protein, nitrogen‐free extract, and digestible crude protein of the examined diets showed no signifcant differences compared with the control diet. The level of DCLF incorporation in diets significantly (p < 0.05) increased the live body weight at 14 weeks; with D3 recording the highest values (2130.9 g) when compared to the D1 and D2 groups. A similar pattern was observed for both daily increase and total body gain (6–14 weeks). Feed conversion recorded insignificant differences among the experimental diets respecting the period 6–14 weeks of age. DCLF levels had a significant effect on dressing and giblet percentages. The chemical composition and color parameters of rabbit meat were similar (p > 0.05), except for fat%, which had the highest value in the D3 group (p < 0.05) compared to the D1 and D2 groups. Economic efficiency was improved by using DLCF up to 35% in terms of gross margin and feed cost/kg gain. In conclusion, using DCLF in the feeding system of rabbits could enhance productive performance, carcass traits, meat quality, and physiological function, as well as improve economic efficiency.
A new approach for vertical bone augmentation: Reconstructing bony peaks before GBR with a customized titanium mesh
Authors: Yu Xinbo , Wang Haowei , Wang Feng , Wu Yiqun 
Published: April 2024

AbstractThis image article presents a single patient receiving a reconstructed fibular bony peak (BP) for guided bone regeneration (GBR) with a customized titanium mesh. The patient was informed and understood the objectives and signed a written informed consent document before surgery.
Two doses of subcutaneous methadone for postoperative analgesia in dogs undergoing tibial plateau levelling osteotomies
Authors: Upchurch D. , Lin K. T. T. , KuKanich B. 
Published: April 2024

ObjectivesTo evaluate analgesia, sedation and adverse effects of two doses of subcutaneous methadone in dogs undergoing tibial plateau levelling osteotomy.Materials and MethodsSeventeen client‐owned dogs undergoing unilateral tibial plateau levelling osteotomy were randomly allocated to receive either 0.25 mg/kg methadone (eight dogs) or 0.5 mg/kg methadone (nine dogs). All dogs were premedicated with methadone and 2 to 6 mcg/kg dexmedetomidine subcutaneously. They were induced and maintained on a standard protocol. All animals received a second dose of methadone subcutaneously 4 hours after premedication and a 4.4 mg/kg dose of carprofen subcutaneously at 8 hours after premedication. During surgery, blood pressure, heart rate and temperature were assessed every 5 minutes. Postoperatively, sedation scores, temperature, heart rate and Glasgow composite modified pain score – short form were assessed for 12 hours postoperatively.ResultsOne of 17 (5.9%) dogs had intraoperative hypotension, nine of 17 dogs had intra‐operative bradyarrhythmias and 17 of 17 dogs had intra‐operative hypothermia. No dogs required intra‐operative rescue. Composite modified pain score – short form scores were below the threshold for intervention in 16 of 17 (94.1%) animals. Only one of 17 (5.9%) dogs required rescue analgesia. Median sedation score was 0 by the T8 time point. Adverse events were rare in both groups with only vocalisation and hypothermia reported commonly postoperatively.Clinical SignificanceTwo doses of methadone at either 0.25 or 0.5 mg/kg administered via subcutaneous injections pre‐operatively and 4 hours later, along with 4.4 mg/kg carprofen subcutaneously 8 hours after the first methadone dose appear to provide sufficient pain control for up to 12 hours in dogs undergoing tibial plateau levelling osteotomy.
Pharmacokinetics of tilmicosin in plasma, urine and feces after a single intragastric administration in donkey (Equus asinus)
Authors: Yang Bowen , Liu Shijie , Guo Yanxin , Qu Honglei , Feng Yulong , Wang Yantao , Dong Boying , Dong Yanjie , Zhao Shancang , Huang Shimeng , Zhao Lihong , Zhang Jianyun , Ji Cheng , Ma Qiugang 
Published: April 2024

AbstractTilmicosin, a macrolide antibiotic, has the potential to treat bacterial infections in donkeys. However, the pharmacokinetics of tilmicosin in donkeys have not been reported. The aim of this study was to investigate the pharmacokinetics of tilmicosin in donkey plasma, urine, and feces after a single intragastric administration to determine the suitability of tilmicosin for donkeys. A total of 5 healthy male donkeys with similar body weights were selected. The donkeys were administered a single dose of 10 mg · kg−1 body weight (BW) tilmicosin by gavage. The concentrations of tilmicosin in plasma, urine, and feces were determined. The results showed that after a single intragastric administration of 10 mg · kg−1 body weight, tilmicosin in donkey plasma reached a maximum concentration of 11.23 ± 5.37 mg · L−1 at 0.80 ± 0.10 h, with a half‐life of 14.49 ± 7.13 h, a mean residence time of 28.05 ± 3.05 h, a Cl/F of 0.48 ± 0.18 L · kg−1 · h−1, and a Vd/F of 9.28 ± 2.63 Lkg−1. The percentage of tilmicosin excreted through the urine of donkeys is 2.47%, and the percentage excreted through the feces is 66.43%. Our study provides data to inform the use of tilmicosin in donkeys.