bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE BIGGER, THE BETTER? TWO-RING CIRCULAR FRAMES AND DURATION OF TREATMENT IN THE MANAGEMENT OF TIBIAL FRACTURES: A RETROSPECTIVE COHORT STUDY
Authors: Hodkinson Thomas , Groom William , Souroullas Panos , Moulder Elizabeth , Muir Ross , Sharma Hemant 
Published: April 2024

IntroductionFrame configuration for the management of complex tibial fractures is highly variable and is dependent not only on fracture pattern and soft tissue condition but also surgeon preference. The optimal number of rings to use when designing a frame remains uncertain. Traditionally, larger, stiffer constructs with multiple rings per segment were thought to offer optimal conditions for bone healing, however, the concept of reverse dynamisation questions this approach.Materials & MethodsWe compared clinical outcomes in 302 consecutive patients with tibial fractures treated in our unit with either a two-ring circular frame or a three-or-more-ring (3+) frame. The primary outcome measure was time spent in frame. Secondary outcomes were the incidence of malunion and the need for further surgical procedures to achieve bone union. The groups were evenly matched for age, co-morbidities, energy of injury mechanism, fracture classification, post-treatment alignment and presence of an open fracture.ResultsThe mean time in frame was 168 days for the 2-ring group and 200 days for the 3+ rings group (p=0.003). No significant difference was found in the rate of malunion (p=0.428) or the requirement for secondary surgical intervention to achieve union (p=0.363). No significant difference in time in frame was found between individual surgeons.ConclusionsThis study finds that 2-ring frame constructs are a reliable option associated with significantly shorter duration of treatment and no increase in rates of adverse outcomes compared with larger, more complex frame configurations. Although this study cannot identify the underlying cause of the difference in treatment time between frame designs, it is possible that differences in mechanical stability lead to a more favourable strain environment for fracture healing in the 2-ring group.
THE SU-PERIOSTEUM: IMPROVING BONE BIOLOGY USING NOVEL CHIMERIC FIBULA-PERIOSTEAL FLAP
Authors: Bandopadhyay Gagori , Lo Steven , Yonjan Indira , Rose Anna , Roditi Giles , Drury Colin , Maclean Angus 
Published: April 2024

IntroductionThe presence of pluripotent mesenchymal cells in the periosteum along with the growth factors produced or released following injury provides this tissue with an important role in bone healing. Utilising this property, vascularised periosteal flaps may increase the union rates in recalcitrant atrophic long bone non-union. The novel chimeric fibula-periosteal flap utilises the periosteum raised on an independent periosteal vessel, thus allowing the periosteum to be inset freely around the osteotomy site, improving bone biology.Materials & MethodsTen patients, with established non-union, underwent fibula-periosteal chimeric flaps (2016–2022) at the Canniesburn Plastic Surgery Unit, UK. Preoperative CT angiography was performed to identify the periosteal branches. A case-control approach was used. Patients acted as their own controls, which obviated patient specific risks for non-union. One osteotomy site was covered by the chimeric periosteal flap and one without. In two patients both the osteotomies were covered using a long periosteal flap.ResultsUnion rate of 100% (11/11) was noted with periosteal flap osteotomies, versus those without flaps at 28.6% (2/7) (p = 0.0025). Time to union was also reduced in the periosteal flaps at 8.5 months versus 16.75 months in the control group (p = 0.023). Survival curves with a hazard ratio of 4.1, equating to a 4 times higher chance of union with periosteal flaps (log-rank p = 0.0016) was observed.ConclusionsThe chimeric fibula-periosteal flap provides an option for atrophic recalcitrant non-unions where use of vascularised fibula graft alone may not provide an adequate biological environment for consolidation.
MIDFOOT CHARCOT ARTHROPATHY: BUTT FRAME CORRECTION FOLLOWED BY BEAMING FOR SEVERE DEFORMITY
Authors: Duguid A , Ankers T , Narayan B , Fischer B , Giotakis N. , Harrison W 
Published: April 2024

IntroductionCharcot neuroarthropathy is a limb threatening condition and the optimal surgical strategy for limb salvage in gross foot deformity remains unclear. We present our experience of using fine wire frames to correct severe midfoot deformity, followed by internal beaming to maintain the correction.Materials and MethodsNine patients underwent this treatment between 2020–2023. Initial deformity correction by Ilizarov or hexapod butt frame was followed by internal beaming with a mean follow up of 11 months. A retrospective analysis of radiographs and electronic records was performed. Meary's angle, calcaneal pitch, cuboid height, hindfoot midfoot angle and AP Meary's angle were compared throughout treatment. Complications, length of stay and the number of operations are also described.ResultsMean age was 53 years (range:40–59). Mean frame duration was 3.3 months before conversion to beaming. Prior frame-assisted deformity correction resulted in consistently improved radiological parameters. Varying degrees of subsequent collapse were universal, but 5 patients still regained mobility and a stable, plantargrade, ulcer-free foot. Complications were common, including hardware migration (N=6,66%), breakage (N=2,22%), loosening (N=3,33%), infection (N=4,44%), 1 amputation and an unscheduled reoperation rate of 55%. Mean cumulative length of stay was 42 days.ConclusionsAggressive deformity correction and internal fixation for Charcot arthropathy requires strategic and individualised care plans. Complications are expected for each patient. Patients must understand this is a limb salvage scenario. This management strategy is resource heavy and requires timely interventions at each stage with a well-structured MDT delivering care. The departmental learning points are to be discussed.
Flat flow solution to the mean curvature flow with volume constraint
Authors: Julin Vesa 
Published: April 2024

Abstract
In this paper I will revisit the construction of a global weak solution to the volume preserving mean curvature flow via discrete minimizing movement scheme by Mugnai, Seis and Spadaro [L. Mugnai, C. Seis and E. Spadaro,
Global solutions to the volume-preserving mean-curvature flow,
Calc. Var. Partial Differential Equations 55 2016, 1, Article ID 18]. This method is based on the gradient flow approach due to Almgren, Taylor and Wang [F. Almgren, J. E. Taylor and L. Wang,
Curvature-driven flows: a variational approach,
SIAM J. Control Optim. 31 1993, 2, 387–438] and Luckhaus and Sturzenhecker [S. Luckhaus and T. Sturzenhecker,
Implicit time discretization for the mean curvature flow equation,
Calc. Var. Partial Differential Equations 3 1995, 2, 253–271] and my aim is to replace the volume penalization with the volume constraint directly in the discrete scheme, which from practical point of view is perhaps more natural. A technical novelty is the proof of the density estimate which is based on second variation argument.
Jenseits der Forderung nach Gewaltfreiheit: Würdige Wut und emanzipatorisches Handeln
Authors: Quintana Laura 
Published: April 2024

Abstract
In this article, Laura Quintana elaborates on a conceptual distinction between violence and rage. Along with this distinction, she recognises that while rage may possess a destructive potential, it can also be politicised in emancipatory practices that confront conditions of injustice and structural violence. Her analysis centers on contemporary political movements in Latin America, which she views as collective manifestations of rage. Within these movements, the manifestation of rage is intertwined with forms of care and communal labor. Quintana characterises such movements as embodying a “dignified rage” (digna rabia) that calls for an emancipatory transformation of the status quo. She contends that these practices can be understood in terms of the notion of “anti-violence,” as it has been coined by Étienne Balibar. In this she diverges from Judith Butler, since, according to Quintana’s analysis, such practices challenge the demand for non-violence that has often served to neutralise the disruptive force of such manifestations and movements.
Idempotent decomposition of regularity and characterization for the accumulation of associated spectrum
Authors: Liu Ying , Jiang Lining 
Published: April 2024

Abstract
Let

𝒜

{\mathcal{A}}

be a complex unital Banach algebra and let

R
⊆
𝒜

{R\subseteq\mathcal{A}}

be a non-empty set. This paper defines the property such that R is closed for idempotent decomposition (in short, (CID) property) to explore the spectral decomposition relation. Further, for an upper semiregularity R with (CID) property,

R
D

{R^{D}}

is constructed as an extension of R to axiomatically study the accumulation of

σ
R

⁢

(
a
)

{\sigma_{R}(a)}

for any

a
∈
𝒜

{a\in\mathcal{A}}

. At last, several illustrative examples on Banach algebra and operator algebra are provided.
Square-integrable representations and the coadjoint action of solvable Lie groups
Authors: Beltiţă Ingrid , Beltiţă Daniel 
Published: April 2024

Abstract
We characterize the square-integrable representations of (connected, simply connected) solvable Lie groups in terms of the generalized orbits of the coadjoint action.
We prove that the normal representations corresponding, via the Pukánszky correspondence, to open coadjoint orbits are type I, not necessarily square-integrable representations.
We show that the quasi-equivalence classes of type I square-integrable representations are in bijection with the simply connected open coadjoint orbits, and the existence of an open coadjoint orbit guarantees the existence of a compact open subset of the space of primitive ideals of the group.
When the nilradical has codimension 1, we prove that the isolated points of the primitive ideal space are always of type I.
This is not always true for codimension greater than 2, as shown by specific examples of solvable Lie groups that have dense, but not locally closed, coadjoint orbits.
Integrated machine learning and multimodal data fusion for patho-phenotypic feature recognition in iPSC models of dilated cardiomyopathy
Authors: Wali Ruheen , Xu Hang , Cheruiyot Cleophas , Saleem Hafiza Nosheen , Janshoff Andreas , Habeck Michael , Ebert Antje 
Published: April 2024

Abstract
Integration of multiple data sources presents a challenge for accurate prediction of molecular patho-phenotypic features in automated analysis of data from human model systems. Here, we applied a machine learning-based data integration to distinguish patho-phenotypic features at the subcellular level for dilated cardiomyopathy (DCM). We employed a human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model of a DCM mutation in the sarcomere protein troponin T (TnT), TnT-R141W, compared to isogenic healthy (WT) control iPSC-CMs. We established a multimodal data fusion (MDF)-based analysis to integrate source datasets for Ca2+ transients, force measurements, and contractility recordings. Data were acquired for three additional layer types, single cells, cell monolayers, and 3D spheroid iPSC-CM models. For data analysis, numerical conversion as well as fusion of data from Ca2+ transients, force measurements, and contractility recordings, a non-negative blind deconvolution (NNBD)-based method was applied. Using an XGBoost algorithm, we found a high prediction accuracy for fused single cell, monolayer, and 3D spheroid iPSC-CM models (≥92 ± 0.08 %), as well as for fused Ca2+ transient, beating force, and contractility models (>96 ± 0.04 %). Integrating MDF and XGBoost provides a highly effective analysis tool for prediction of patho-phenotypic features in complex human disease models such as DCM iPSC-CMs.
Infinitely many solutions for a p(x)-triharmonic equation with Navier boundary conditions
Authors: Belakhdar Adnane , Belaouidel Hassan , Filali Mohammed , Tsouli Najib 
Published: April 2024

Abstract
In this work, we will study the existence of an infinity of solutions of a Navier problem governed by the

p
⁢

(
x
)

{p(x)}

-triharmonic operator using the theory of Ljusternick–Shrilemann and the theory of the variable exponent Sobolev spaces.
Effect of pH in the bismuth vanadate nanorods for their supercapacitor applications
Authors: Suganya Palani , Shankar Veerasamy Uma , Mona Yuttana , Chaichana Chatchawan , Vignesh Shanmugam , Sundramurthy Venkatesa Prabhu , Untisso Tarikayehu Amanuel , Oh Tae Hwan 
Published: April 2024

Abstract
The different pH-varied bismuth vanadate nanorods have been synthesized through a solvothermal method and utilized for XRD, HRTEM, SEM and electrochemical studies. The XRD spectra of BV-5 and BV-7 samples show the monoclinic structure. Both electrodes show rod-like morphology. Also, when the pH 7 the bismuth oxide shows large size nanorods compared with pH 5. The interspacing distance of the samples were reduced while the pH was increased. The electrochemical performance of the prepared BV-5 and BV-7 shows higher capacitance values of 235 and 167 F/g for BV-5 and BV-7 electrodes, also these electrodes show a maximum energy density value of 13.4 and 18.8 Wh/kg and related power density values are 720 and 867 W/kg, respectively. The power density value of the BV-7 electrode was increased without affecting the energy density value. Moreover, the cyclic retention of BV-7 shows 93 % at the 1000th cycle. Also, the capacitance and Rct values of BV-7 electrode are comparatively higher than pure BV-5 electrode.
FORMATION OF ORAL SPEECH SKILLS IN FUTURE PRIMARY LANGUAGE TEACHERS OF PRIMARY SCHOOL IN ENGLISH LANGUAGE CLASSES
Authors: Martyn Natalia 
Published: April 2024

Today, the content of teaching foreign languages in secondary schools of Ukraine is being significantly updated, which is primarily due to the implementation of the Concept of the New Ukrainian School. Among the 10 key competences, the strategic educational document distinguishes communication in foreign languages. Thus, the formation of communicativeskills of the future primary school teacher in the system of higher education is one of the priority tasks.The aim of the article is to substantiate the communicative aspect of the formation of oral skills, training of future primary school teacher of English as a component of his language competence.The content of English language teaching of students is based on the following main characteristics: it corresponds to the actual communicative and cognitive interests of future teachers of English, reflects the real needs of the use of language as a means of communication, is as close as possible to the conditions and goals of real intercultural communication; stimulates the development of interests and positive attitude to the English language, influences their motivational sphere; based on the experience of mastering the native language; takes into account the general educational experience of students which has been acquired during the mastering of the school foreign language course, as well as other subjects(interdisciplinary links); stimulates students’ independent activity, encourages reflection on the quality of their own academic achievements and thedesire to improve them.In order to develop the skills of oral speech(speaking) in future teachers of English, the teacher, first of all needs to create preconditions for the organization of an active educational process, to prepare the appropriate educational and didactic base, to choose the optimal educational and methodological materials etc. It will be appropriate to use innovative educational technologies, for example, the use of video materials, which will significantly intensify the learning process, to increase the level of language competence of future teachers of English, to expand the range of use of methodological tools in teaching.
Influence of blood electrolyte levels on the risk of atrial fibrillation after cardiac surgery
Authors: Tatarintseva Z. G. , Kosmacheva E. D. , Babicheva O. V. 
Published: April 2024

Aim. To analyze the relationship of low blood potassium concentration before surgery with the risk of postoperative atrial fibrillation (POAF).Material and methods. Data were collected and analyzed from patients admitted to the intensive care unit after cardiac surgery between January 2023 and June 2023. During the study period, 691 patients were operated on. Of these, 96 (13,9%) patients developed POAF, which made up group A (mean age 68,3±10,0). Control group B of patients with sinus rhythm was formed using a random generator and consisted of 96 patients with a mean age of 63,5±8,3.Results. The median time to onset of arrhythmia was 39,0 (29,2-51,0) hours. The blood potassium concentration one hour before surgery was significantly reduced in patients who developed arrhythmia compared with the control group (p<0,001) and averaged 3,4±0,4 mmol/L. To determine the sensitivity and specificity of the association of hypokalemia with POAF, we used a confirmatory statistical method, namely constructing ROC curves (AUC 0,640 (95% confidence interval: 0,562-0,718; p<0,001)).Conclusion. This study demonstrated the association of low preoperative blood potassium concentrations with the risk of POAF. Electrolyte concentrations alone cannot fully explain the risk of arrhythmia. However, optimizing electrolyte balance and, in particular, maintaining potassium concentrations >4,5 mmol/L may prevent the atrial fibrillation in some patients.
Lipid profile changes after the acute COVID-19 period. Sub-analysis of the International Registry "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors" (AKTIV SARS-CoV-2)" (12-month follow-up)
Authors: Arutyunov G. P. , Tarlovskaya E. I. , Arutyunov A. G. , Polyakov D. S. , Grigorieva N. Yu. , Gubareva I. V. , Kamilova U. K. , Kim Z. F. , Kuznetsova A. S. , Kuznetsova T. Yu. , Ruzanov D. Yu. , Svarovskaya A. V. , Smirnova E. А. , Sugraliev A. B. , Frolova I. A. , Aimakhanova G. T. , Batluk T. I. , Bashkinov R. A. , Bikushova I. V. , Gordeychuk E. D. , Gubareva E. Yu. , Evdokimov D. S. , Zakirova G. A. , Loginova A. O. , Melnikov E. S. , Moiseenko N. B. , Trubnikova M. A. , Shcherbakov S. Yu. 
Published: April 2024

Aim. To analyze the lipid profile changes during the acute phase of coronavirus disease 2019 (COVID-19) and within 12 months after discharge from the hospital (post-Covid period) in comparison with the lipid profile of patients before COVID-19.Material and methods. The subanalysis of the registry was carried out as follows: clinical investigators in each of the centers included patients in the AKTIV registry selected from the database patients who met three following criteria: (1) availability of lipid profile test no more than 60 days before COVID-19; (2) availability of lipid profile test during the acute period; (3) availability of lipid profile test within 6-12 months after discharge from the hospital.Results. In patients after COVID-19, a decrease in the levels of all lipid profile parameters in the acute COVID-19 phase and their subsequent increase were found.In the post-COVID-19 period, 25,7% of patients experienced an increase in lipid profile parameters (increased levels of total cholesterol (TC) and/or cholesterol, low-density lipoproteins and/or triglycerides and/or cholesterol excluding high-density lipoproteins by ≥0,5 mmol/l) despite the fact that lipid-lowering therapy in these patients was at least no worse than in patients without lipid profile changes.Multivariate analysis found that such variables as age (direct relationship), body mass index (direct relationship), estimated glomerular filtration rate in the acute phase (inverse relationship) and cholesterol level excluding high-density lipoproteins in the acute period (inverse relationship), as well as heart failure, obesity and cytokine storm in the acute COVID-19 phase are independent predictors of an increase in one or more lipid parameters by ≥0,5 mmol/l over 6-12 months of post-COVID-19 period.Conclusion. COVID-19 likely contributes to the onset and/or progression of lipid metabolism disorders in COVID-19 survivors (Eurasian population).
Association of Integrated Proteomic and Metabolomic Modules with Risk of Kidney Disease Progression
Authors: Schlosser Pascal , Surapaneni Aditya L. , Borisov Oleg , Schmidt Insa M. , Zhou Linda , Anderson Amanda , Deo Rajat , Dubin Ruth , Ganz Peter , He Jiang , Kimmel Paul L. , Li Hongzhe , Nelson Robert G. , Porter Anna C. , Rahman Mahboob , Rincon-Choles Hernan , Shah Vallabh , Unruh Mark L. , Vasan Ramachandran S. , Zheng Zihe , Feldman Harold I. , Waikar Sushrut S. , Köttgen Anna , Rhee Eugene P. , Coresh Josef , Grams Morgan E. ,   on behalf of the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators and the CKD Biomarkers Consortium
Published: April 2024

Key Points

Integrated analysis of proteome and metabolome identifies modules associated with CKD progression and kidney failure.Ephrin transmembrane proteins and podocyte-expressed CRIM1 and NPNT emerged as central components and warrant experimental and clinical investigation.

Background
Proteins and metabolites play crucial roles in various biological functions and are frequently interconnected through enzymatic or transport processes.

Methods
We present an integrated analysis of 4091 proteins and 630 metabolites in the Chronic Renal Insufficiency Cohort study (N=1708; average follow-up for kidney failure, 9.5 years, with 537 events). Proteins and metabolites were integrated using an unsupervised clustering method, and we assessed associations between clusters and CKD progression and kidney failure using Cox proportional hazards models. Analyses were adjusted for demographics and risk factors, including the eGFR and urine protein–creatinine ratio. Associations were identified in a discovery sample (random two thirds, n=1139) and then evaluated in a replication sample (one third, n=569).

Results
We identified 139 modules of correlated proteins and metabolites, which were represented by their principal components. Modules and principal component loadings were projected onto the replication sample, which demonstrated a consistent network structure. Two modules, representing a total of 236 proteins and 82 metabolites, were robustly associated with both CKD progression and kidney failure in both discovery and validation samples. Using gene set enrichment, several transmembrane-related terms were identified as overrepresented in these modules. Transmembrane–ephrin receptor activity displayed the largest odds (odds ratio=13.2, P value = 5.5×10−5). A module containing CRIM1 and NPNT expressed in podocytes demonstrated particularly strong associations with kidney failure (P value = 2.6×10−5).

Conclusions
This study demonstrates that integration of the proteome and metabolome can identify functions of pathophysiologic importance in kidney disease.