bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuropilin-1 Binding Peptide as Fusion to Diphtheria Toxin Induces Apoptosis
in Non-small Cell Lung Cancer Cell Line
Authors: Eghtedari Sara , Behdani Mahdi , Kazemi-Lomedasht Fatemeh 
Published: April 2024

Background::
Targeted cancer therapy can be considered as a new strategy to overcome the side effects
of current cancer treatments. Neuropilin-1 (NRP-1) is a transmembrane glycoprotein that is expressed in
endothelial cells and tumor vessels to stimulate angiogenesis progression. Targeted diphtheria toxin (DT)-
based therapeutics are promising tools for cancer treatment. This study aimed to construct a novel NRP-1 binding
peptide (as three repeats) (CRGDK) as a fusion to truncated DT (DTA) (DTA-triCRGDK) for targeted delivery
of DT into NRP-1 expressing cells.

Methods::
The concept of DTA-triCRGDK was designed, synthesized and cloned into the bacterial host. Expression
of DTA-triCRGDK was induced by Isopropyl ß-D-1-thiogalactopyranoside (IPTG) and purification
was performed using Ni-NTA chromatography. Biological activity of DTA-triCRGDK was evaluated using
MTT, apoptosis, and wound healing assays. In addition, expression levels of apoptotic Bax, Bcl2, and Casp3
genes were determined by Real-time PCR.

Results::
Cytotoxicity analysis showed the IC50 values of DTA-triCRGDK for A549 and MRC5 were 0.43 nM
and 4.12 nM after 24 h, respectively. Bcl2 expression levels decreased 0.4 and 0.72 fold in A549 and MRC5,
respectively. However, Bax and Casp3 expression level increased by 6.75 and 8.19 in A549 and 2.51 and 3.6
in MRC5 cells.

Conclusion::
Taken together, DTA-triCRGDK is a promising tool for targeted therapy of NRP-1 overexpressing
cancer cells.
Fat-soluble Vitamins and Lung Cancer: Where We Are?
Authors: Lin Xue , Wang Yaxuan , Zhang Tongzuo , Pu Xiaoyan 
Published: April 2024

Abstract:
Fat-soluble vitamins (vitamins A, D, E, and K) are vital substances for maintaining normal physiological functions
in the body. In recent years, scholars have explored the relationship between fat-soluble vitamins and the
wasting disease - lung cancer. In this paper, we review recent studies on fat-soluble vitamins and lung cancer
to clarify the relevance and molecular mechanisms of various vitamins in lung cancer, and whether the levels
of fat-soluble vitamins in the body and vitamin supplementation affect the development of lung cancer. Our review
could facilitate the discovery of biomarkers, potential therapeutic targets in lung cancer, and anti-tumor
adjuvant drugs, in addition to highlighting other new ideas in the prevention and treatment of lung cancer.
Research on Cultivation Mechanism of College Managers in the Context of "Double First-class" Construction
Authors: Wu Juan 
Published: April 2024

The construction of world-class universities and first-class disciplines is a major strategic decision made by the CPC Central Committee, which is of great significance for enhancing the level of China's educational development, strengthening the core competitiveness of the country and laying the foundation for long-term development. As an important part of the university faculty, university administrators will become specific organizers and implementers of school development and discipline construction in the context of "double first-class". However, at present, the overall ability and quality of university management personnel are not yet compatible with the requirements of "double first-class" university construction. Therefore, it is urgent to cultivate and build a team of managers who are both moral and talented, who know their profession, who understand education, who are good at management, and who have a reasonable structure and are relatively stable, so as to make sure that they are compatible with the construction and development of the "double first-class" universities.
COMPUTER MODELING OF ENERGY-EFFICIENT JOINTS OF WOOD COMPOSITE PANELS
Authors: Lukin Mikhail , Roshchina Svetlana , Lukina Anastasiya , Rimshin Vladimir 
Published: April 2024

High air permeability and the presence of thermal bridges at the junctions of wooden frame wall panels have a significant impact on the thermal balance of the building and its operational characteristics. The importance of improving the energy efficiency of nodal interfaces of panels with a wooden frame is undeniable.
To date, there is no single generally accepted method for calculating heat losses through nodal interfaces of panels with a wooden frame. Based on the analysis carried out, it is necessary to carry out calculations and measurements that allow creating this calculation methodology. To carry out numerical studies, a list of characteristics and parameters affecting their conduct is formulated: the influence of the thickness of a li-ear-discrete inclusion on the heat-protective properties of the panel docking unit; the thermal conductivity characteristics of the material used to fill linear-discrete inclusions affecting the heat flux density of the node interface; consideration of the influence of the outdoor temperature of air depending on different climatic zones on the density of heat flow. The dependences of the heat flux density on the "inner" surface of the experimental samples on the thermal conductivity coefficient of the material of the insulating insert, the width of the insulating insert and the outside air temperature were revealed and the nature of the temperature distribution on the "inner" surface of the prototypes was established. By calculating two-dimensional temperature fields in the cross section of the node, isofields of temperature distribution inside the structure, isofields of heat flux density and its direction, lines of temperature distribution and heat flux density along the inner and outer surfaces are obtained. It was found that the heat flux density in the ribs with heat-insulating inclusions is lower in comparison with solid wood parts by an amount from 13% to 52%.
Josefa
Authors: R A Sosa Trotti 
Published: April 2024

En 1992, cuando mi país apenas se desahogaba de la hiperinflación, me dirigía a atender en una salita ubicada en una barriada muy humilde.
Llego, saludo a todos mientras recibo de la administrativa la planilla de pacientes donde registraban nombres y edades. La edad separada en dos columnas, una para cada sexo. Doy un vistazo rápido y noto que alguien tenía anotada la edad en la columna de los hombres, veinticuatro años, pero de nombre Josefa Jara. Inmediatamente me sonó un campanazo y, a velocidad luz, arremetió el recuerdo de un compañero de residencia de “tocogineco” que había consentido recetar abundantes dosis de hormonas femeninas a un travesti, con la idea de que se le desarrollen los pechos, o lo que sea. Mi recuerdo fue fugaz pero rotundo.

Atendí mis "pacientitas", algunas embarazadas y otras no. Llegó el turno del "mi caso incierto", llamé firme: “¡JosefJara!”, de un solo tirón. El inconsciente, muy puntual, ya se había metido. Y así fue que llamé con un nombre ni de hombre, ni de mujer.
ANALISIS EFEKTIVITAS PENGGUNAAN MULTIMEDIA PEMBELAJARAN DIGITAL DI SEKOLAH DASAR
Authors: Savitri Nabila Defani , Putri Peni Indriyani , Wulandari Sri , Alpian Yayan 
Published: April 2024

Abstract: This research on analysis of the use of learning multimedia aims to find out the extent to which schools implement and know about digitalization in schools. By introducing digital media to schools from elementary school level, it will also have a good impact on students' development in their efforts to utilize technology in the future. The research method used in this research is a qualitative descriptive method with interview techniques and questionnaires filled in by students regarding the use of digital learning media in their school. And the factors causing the ineffective use of digital multimedia at SDN Nagasari 4 are influenced by several external and internal factors.Keyword: multimedia, digital media, learning Abstrak: Penelitian tentang analisis pengguanaan multimedia pembelajaran ini bertujuan untuk mengatahui sejauh mana sekolah menerapakan dan mengetahui tentang digitalisasi di sekolah. Dengan mengenalkan media digital ke sekolah sejak jenjang sekolah dasar maka akan berdampak baik juga untuk perkembangan siswa dalam upaya pemanfaatan teknologi kedepannya. Metode penelitian yang di gunakan dalam penelitian ini adalah metode deskriptif kualitatif dengan Teknik wawancara dan kuisisoner yang di isi oleh siswa seputar pengguanaan media pembelajaran digital di sekolahnya. Dan faktor penyebab kurang efektifnya penggunaan multimedia digital di SDN nagasari 4 di pengaruhi oleh beberapa faktor eksternal dan internal .Kata Kunci: multimedia, media digital, pembelajaran
Seroepidemiología de Neospora caninum en caninos en Córdoba, Colombia
Authors: Daza-Rodríguez Jhon Alexander , Herrera-Benavides Yonairo Manuel , Hincapié-Márquez Sebastián 
Published: April 2024

Objetivo. Estimar la seroprevalencia de la Neospora caninum en caninos de áreas rurales del departamento de Córdoba, Colombia. Materiales y métodos. Se realizó un estudio de tipo descriptivo exploratorio de corte transversal a conveniencia en 180 perros de 5 municipios del departamento de Córdoba. Las muestras tomadas fueron de sueros sanguíneos y analizados mediante la técnica de ELISA competitiva utilizando para ello el kit comercial ID Screen® Neospora caninum Competition (LMV S.A.S.). Resultados. La seropositividad general de anticuerpos contra N. caninum fue de 1,61% (3/180). En cuanto a la variable sexo, se obtuvo una frecuencia en machos del 1.92% (2/104) y hembras del 1.31% (1/76). En cuanto al grupo etario se obtuvo que la seropositividad a N. caninum únicamente en el grupo de adultos 3.61% (3/83), en la variable estado reproductivo y raza se evidenció que los individuos seropositivos fueron mestizos (3/173) y enteros (3/177), el grupo de talla grande fueron los únicos con seropositividad 7,69% (3/39). Conclusión. A pesar de ser una seropositividad muy baja con relación a otros estudios nacionales, permite evidenciar la presencia de N. caninum en el departamento de Córdoba y región Caribe, al ser el primer estudio en caninos.
Construcción del sentido de vida y responsabilidad social.
Authors: Correa Arias César , Caro Beltrán Amelia Guadalupe 
Published: April 2024

El sentido de vida y la responsabilidad social son trascendentales en el coexistir con la humanidad, ya que posibilitan experiencias dotadas de conciencia para la comprensión y la toma de decisiones acerca de nuestra existencia. Con referencia a jóvenes universitarios representa un proceso decisivo de sus vidas, debido a que es una etapa de múltiples cambios físicos, emocionales, intelectuales y sociales.
El objetivo de esta investigación es analizar cómo los jóvenes universitarios construyen su sentido de vida en una universidad pública en México y, a la vez, identificar sus capacidades y potencialidades que les permita contribuir en el fortalecimiento de sus proyectos de vida para una mayor conciencia de sí mismo y la necesaria responsabilidad con la otredad.
El estudio utiliza una metodología mixta, con un enfoque hermenéutico-fenomenológico y una perspectiva psico-sociológica centrado en las experiencias de percepción que los estudiantes tienen de sí mismos y de otras personas que son significativas en sus vidas. La investigación utiliza el cuestionario LOGOTEST y PIL, además de entrevistas semiestructuradas.
La pregunta central se refirió a, ¿Qué significados brindan los estudiantes a sus existencias y de qué manera los utilizan como medio para comprender el sentido y proyecto de vida que construyen dentro de sus trayectos de vida y formación?
Se concluyó que los estudiantes reportan serias dificultades en la construcción de la identidad personal, el reconocimiento y aceptación de sus potencialidades con un claro detrimento de su autoestima, lo que dificulta la construcción de un sentido de vida que permita el profundo desarrollo de la subjetividad e intersubjetividad. Así, los estudiantes construyen su sentido de vida en función de establecer lazos familiares que les permitan avanzar en sus vidas y contar con metas y propósitos claros para el desarrollo profesional y para ubicarse en el mercado laboral.
protección social a través de la “reforma” de los subsidios de desempleo para una transición justa climática
Authors: Álvarez Cuesta Henar 
Published: April 2024

La reforma llevada a cabo por el no convalidado RD-Ley 7/2023 en los subsidios por desempleo tiene como objetivos los siguientes: simplificar su percepción, extender su ámbito subjetivo de personas beneficiarias y, al tiempo, pretende impulsar una activación para el empleo más intensa de las personas subsidiadas a través de la compatibilidad entre trabajo y prestación. A la luz de los cambios mencionados, se trata de comprobar si la reducción del puzle del subsidio por desempleo sirve para proteger realmente a quien más necesita una red de supervivencia frente a las consecuencias de las medidas de adaptación o mitigación frente al cambio climático y si se cumplen los requisitos que una transición justa frente al cambio climático precisa, esto es, la formación y recualificación de las personas trabajadoras dentro de la economía verde o circular y la protección de las personas que han perdido su puesto de trabajo o ven impedida su actividad productiva.
Navigating Around Conflict: The Indonesia Way to Initiating Peace Talk in the South China Sea Dispute
Authors: Pedrason Rodon , Haryanto Agus , Yusuf Muhamad , Setyoko Paulus Israwan 
Published: April 2024

Objective: This paper aims to unravel the pattern of Indonesia's diplomatic maneuver in the South China Sea dispute over the years.

Result and conclusion: We conclude that Indonesia has repeatedly shown a tendency to take the initiative and lead the talks to promote a peaceful settlement. The proposed zero drafts in 2012 indicate Indonesia's strategy to lead the conversation toward peaceful agenda. In order to execute its diplomatic maneuver, Indonesia repeatedly exploited ASEAN Forum to achieve milestones in the South China Sea peaceful settlement.

Research implication: The South China Sea has been diplomatic for Indonesia's Foreign Policy for ages. In response to the matters, Indonesia has been persistently implementing two diplomatic alternatives by enforcing formal diplomatic ways utilizing the ASEAN forum and executing an informal path through Managing Potential Conflict in the South China Sea.

Originality/value: The two ways have been a fundamental Indonesian foreign policy landscape towards South China Sea dispute since the 1990s until arguably 2014. Various scholarly manuscripts conclude that the approach proved unsuccessful in effectively bringing a settlement to the South China Sea disputes.
Production and sale of handicraft toys by Russian Zemstvos
Authors: Ugryumova Mariya Viktorovna , Fomenko Marina Viktorovna 
Published: April 2024

The activities of the zemstvo self-government bodies to support handicrafts occupied a special place in many territories of pre-revolutionary Russia. Through the creation of workshops for the production of handicrafts, special schools, creative associations, museums and connections with individual handicrafts, the zemstvo productively established the production of artisanal domestic toys. Individual zemstvos were actively engaged in advertising the toy, its sale both domestically and abroad through regional, Russian and European exhibitions. The organization of sales outlets and a specialized Moscow store, coordination of packaging and shipment of individual toys or their batches were also included in the scope of activity of the zemstvos. The subject of this study is the activity of Russian zemstvos in organizing the production and sale of handicraft toys in the second half of the XIX – early XX centuries. The main methodological foundations of this research are the principles of scientific objectivity, consistency and historicism. The center, of course, is the method of searching for archival documents, and a retrospective method of studying the activities of individual zemstvos in organizing training in the art of creating toys, its production and sale on domestic and foreign sites. During the research, the author discovered, analyzed and for the first time introduced into scientific circulation documents containing data on the organization of production and sale of handicraft toys by the zemstvo authorities, which were deposited in the fund of the Moscow Provincial Zemstvo (both in the cases of structural divisions of the zemstvo, the Handicraft Museum, and in individual cases of the county zemstvos of the Moscow province) and are stored in The Central State Historical Archive of Moscow (TSGIA of Moscow), various reports and indexes of handicraft, industrial and art exhibitions. Of course, the main centers of the appearance of handicraft toys, in the production and marketing of which the zemstvo participated, were the Moscow province with handicrafts from Sergiev Posad and S. Bogorodsky, Nizhny Novgorod, Vyatka, Tambov, Perm and Kazan provinces.
Etiology and outcome of hypoglycemia in young children: A retrospective cohort study
Authors: Chai Xin Yean , Shaikh M. Guftar , McNeilly Jane D. 
Published: April 2024

Objectives:
Hypoglycemia is one of the most common presenting complaints at a pediatric emergency department. There are many distinct causes of hypoglycemia, ranging from nutritional insufficiency to infectious origins to metabolic disorders. Full clinical assessment and appropriate investigations can help differentiate the cause of hypoglycemia with subsequent tailored management. All patients with hypoglycemia should have a full clinical assessment together with a hypoglycemia screen if appropriate. This clinical review aims to determine the investigation of hypoglycemia in young children (<6 years) and whether these patients received a subsequent diagnosis and adequate follow-up plans.

Material and Methods:
The laboratory database searched for all children from 0 to 6 years old, with hypoglycemia defined as plasma glucose (PG) <54.0 mg/dL (or <3.0 mmol/L) from 2013 to 2021 at the Royal Hospital of Children, Glasgow. Cases were reviewed for the biochemistry investigations to determine if they had hypoglycemia screening requested and/or performed the presenting complaint, clinical diagnosis, and subsequent follow-up arrangements.

Results:
Five hundred and one children were identified with hypoglycemia (PG <54.0 mg/dL) over a 9-year period. Of these patients, 28% (142/501) had a full hypoglycemia screen, 38% had a partial screen, and 34% (166/501) had no additional blood tests related to hypoglycemia screening other than a PG. The cause of hypoglycemia was identified in 15% (77/501), with gastroenteritis being the most common cause. Of those who were hypoglycemic, 48% (240/501) had an ongoing follow-up. Among those with severe hypoglycemia (PG ≤27.0 mg/dL) (86/501), causes were identified in 72% (62/86) and 63% (54/86) of this cohort which was followed up after the first presentation.

Conclusion:
Screening was not consistently performed for all patients presenting with hypoglycemia. A great portion of patients were not fully investigated or followed up. This could be a result of clinical judgment in the assessment of further investigation for hypoglycemia. However, moderate and severe hypoglycemia still require further investigations, which can potentially lead to long-term consequences if not managed appropriately.
Comparing equiosmolar hypertonic saline and mannitol for achieving brain relaxation in elective craniotomy patients: A systematic review and meta-analysis
Authors: Rangwala Burhanuddin Sohail , Noor Tooba , Shakil Areej , Mustafa Muhammad Saqlain , Shafique Muhammad Ashir , Manan Sadia , Qamber Amna , Zaidi Syeda Dua E Zehra , Obaid Muhammad Adil , Munawar Irja , Rizvi Sabah , Rangwala Hussain Sohail 
Published: April 2024

Background:
This study strives to provide a current and thorough assessment of the comparative efficacy and safety between equiosmolar quantities of hypertonic saline (HS) and mannitol in facilitating brain relaxation for patients undergoing elective craniotomies.

Methods:
This systematic review and meta-analysis, following preferred reporting items for systematic reviews and meta-analyses guidelines, compared the efficacy and safety of equiosmolar concentrations of mannitol and HS in elective craniotomies. PubMed, Scopus, Cochrane Library, ScienceDirect, and Proquest databases were searched using keywords related to mannitol, HS, and craniotomy. Results were analyzed through a random-effects model using Mantel–Haenszel risk ratio and standard mean difference. P < 0.05 was considered significant.

Results:
Thirteen randomized controlled trials encompassing 965 patients (516 in the HS group and 448 in the mannitol group) were analyzed. The quality of studies was moderate-to-high, and no significant publication bias was observed. The primary outcome, brain relaxation, favored HS over mannitol without significant heterogeneity. Mannitol was associated with increased urine output compared to HS, irrespective of dose, with high heterogeneity. HS was linked to significantly reduced fluid input, confirmed by subgroup analysis with lower heterogeneity. No significant difference was found in serum osmolality between the two agents. Serum sodium (Na+) levels favored HS, whereas arterial blood Na+ levels also favored HS despite considerable heterogeneity. Maximum mean arterial pressure was higher with HS, but it displayed significant heterogeneity. Maximum central venous pressure showed no significant difference between the two agents, with moderate heterogeneity.

Conclusion:
HS appears more effective than mannitol in achieving brain relaxation, and it may offer advantages in fluid management and Na+ balance. Clinicians should consider these findings when selecting hyperosmotic agents for neurosurgical procedures. Further research is needed to address heterogeneity in certain outcomes and guide clinical practice.
Аdvertisement of European multiculturalism and its impact on interfaith relations in Ukraine
Authors: Kobetiak A. 
Published: April 2024

The article proposes a study of state-church and inter-religious relations in Ukraine during the period of independence in the context of political processes in modern Europe. The modern vectors of state policy in the sphere of religion and freedom of conscience are revealed. The insult in interfaith relations is largely caused by the ill-conceived and inconsistent policy of the government in this area. It has been established that the current political situation in Ukraine indicates a deep crisis in relations in many spheres of social life. Russia's open aggression caused a new wave of aggravation of national self-identification and the church vector in Ukraine. The purpose of the article is to highlight the problem of the political and spiritual influence of Europe on modern Orthodoxy in Ukraine, which is in a state of division into different jurisdictions. It has been proven that the unification of the divided branches of Ukrainian Orthodoxy will contribute to the consolidation of Ukrainian society, especially in conditions of open war. The formation of the United Church should take place on the basis of a constructive dialogue between the authorities, denominations and society.
The research shows that the branches of the divided Ukrainian Orthodoxy are under the active political influence of the geopolitical confrontation of the European scale. Advertising and promotion of multiculturalism and polytheism, which are characteristic of the countries of Western Europe, require corresponding freedom of religion and the presence of a multi-religious component in Ukraine, which openly demonstrates the chosen vector of European integration.
On the other hand, it was established that the status of the United Independent Church affects issues of national security, international recognition, geopolitical influence, consolidation of Ukrainian society, unification of self-identification of Ukrainian citizens and is an important conflict-causing factor. Therefore, the issue of establishing the United Independent Ukrainian Church remains topical today.