bluuebunny/crossref_metadata_2025_split huggingface dataset:
Probable Non–Ventilator-Associated Hospital-Acquired Pneumonia: A Case Report
Authors: Rathbun Kimberly Paige , Bourgault Annette M. , Sole Mary Lou 
Published: April 2024

Introduction
Non–ventilator-associated hospital-acquired pneumonia is a preventable health care–associated infection accounting for 1 in 14 hospital deaths. Clinical factors influencing this condition include oral health and bacteria and oral care. This case report addresses diagnostics and clinical variables related to non–ventilator-associated hospital-acquired pneumonia and emphasizes the importance of prevention.

Clinical Findings
A 90-year-old woman was admitted to the hospital with shortness of breath and generalized weakness from new-onset atrial fibrillation and suspected heart failure exacerbation. During the hospitalization, her oral health status declined and oral bacterial colonization shifted, with Neisseria becoming the most common oral bacterial genus around the time of development of probable non–ventilator-associated hospital-acquired pneumonia.

Diagnosis
The patient had new respiratory symptoms and a chest radiograph positive for pneumonia on day 4 and was subsequently diagnosed with probable non–ventilator-associated hospital-acquired pneumonia.

Interventions
Intravenous antibiotic treatment was initiated. Oral care was completed on only 2 of 7 days. The patient received limited ambulation assistance and encouragement from staff and family members. No dysphagia screening was documented.

Outcomes
On day 6, the patient was discharged with oral antibiotics to her independent living facility with home health care.

Conclusions
Consistent oral care, early and frequent physical activity, and measures aimed to reduce aspiration risk are key interventions for all hospitalized patients to prevent non–ventilator-associated hospital-acquired pneumonia. Further research is warranted to assess shifts in oral bacteria and general oral health during hospitalization, which could provide clinically meaningful data on risk for non–ventilator-associated hospital-acquired pneumonia.
Critical Care Alarm Fatigue and Monitor Customization: Alarm Frequencies and Context Factors
Authors: Arkilic Layla Z. , Hundt Elizabeth , Quatrara Beth 
Published: April 2024

Background
Alarm fatigue among nurses working in the intensive care unit has garnered considerable attention as a national patient safety priority. A viable solution for reducing the frequency of alarms and unnecessary noise is intensive care unit alarm monitor customization.

Local Problem
A 24-bed cardiovascular and thoracic surgery intensive care unit in a large academic medical center identified a high rate of alarms and associated noise as a problem contributing to nurse alarm fatigue.

Methods
An alarm monitor quality improvement project used both alarm frequency and nurse surveys before and after implementation to determine the effectiveness of interventions. Multimodal interventions included nurse training sessions, informational flyers, organizational policies, and an alarm monitor training video. Unexpected results inspired an extensive investigation and secondary analysis, which included examining the data-capturing capabilities of the alarm monitors and the impact of context factors.

Results
Alarm frequencies unexpectedly increased after the intervention. The software data-capturing features of the alarm monitors for determining frequency did not accurately measure nurse interactions with monitors. Measured increases in patient census, nurse staffing, and data input from medical devices from before to after the intervention substantially affected project results.

Conclusions
Alarm frequencies proved an unreliable measure of nurse skills and practices in alarm customization. Documented changes in context factors provided strong anecdotal evidence of changed circumstances that clarified project results and underscored the critical importance of contemporaneous collection of context data. Designs and methods used in quality improvement projects must include reliable outcome measures to achieve meaningful results.
Does the setting for intradetrusor onabotulinumtoxinA injection for management of overactive bladder matter?
Authors: Ross James H. , Abrams Megan , Vasavada Sandip P. , Mangel Jeffrey M. , Ferrando Cecile A. 
Published: April 2024

ABSTRACT

Introduction:
Intradetrusor onabotulinumtoxinA (Botox) injections, to treat idiopathic overactive bladder (OAB), can be performed in the office setting under local analgesia alone or in the operating room (OR) under local and/or sedation. The objective of this study was to compare the symptomatic improvement in patients with OAB who underwent treatment with intradetrusor onabotulinumtoxinA injections in an in-office versus the OR setting.

Methods:
We performed a multicenter retrospective cohort study of women with the diagnosis of refractory non-neurogenic OAB who elected to undergo treatment with intradetrusor onabotulinumtoxinA injections between January 2015 and December 2020. The electronic medical records were queried for all the demographic and peri-procedural data, including the report of subjective improvement post procedure. Patients were categorized as either “in-office” versus “OR” based on the setting in which they underwent their procedure.

Results:
Five hundred and thirty-nine patients met the inclusion criteria: 297 (55%) in the in-office group and 242 (45%) in the OR group. A total of 30 (5.6%) patients reported retention after their procedure and it was more common in the in-office group (8.1%) versus the OR group (2.5%), (P = 0.003). The rate of urinary tract infection within 6 months of the procedure was higher in the OR group (26.0% vs. 16.8%, P = 0.009). The overall subjective improvement rate was 77% (95% confidence interval: 73%–80%). Patients in the OR group had a higher reported improvement as compared to the in-office group (81.4% vs. 73.3%, P = 0.03).

Conclusions:
In this cohort study of patients with OAB undergoing intradetrusor onabotulinumtoxinA injections, post procedural subjective improvement was high regardless of the setting in which the procedure was performed.
Translation, cross-cultural adaptation, reliability, validation of King’s Health Questionnaire in the Marathi language
Authors: Joshi Reema , Rathi Manisha 
Published: April 2024

ABSTRACT

Introduction:
Outcome measurement is a crucial component of contemporary professional practice. Many Indian rehabilitation facilities employ the King’s Health Questionnaire (KHQ), but there has never been an official Marathi translation with its reliability and validity.

Materials and Methods:
As per the recommendations for cross-cultural validation of an outcome assessment, KHQ was translated into the Marathi language at a tertiary hospital in Pune, India. A study was conducted to assess the dependability of 123 patients from tertiary hospitals in India. The reliability of the study was assessed by two competent physiotherapists. The interrater reliability of the KHQ total scores and each item was evaluated using Cronbach’s alpha coefficient. To compare the interrater dependability with the findings of other investigations, the intraclass correlation (ICC) coefficient was determined.

Results:
When evaluated by domain, the KHQ’s standardized Cronbach’s alpha ranged from 0.49–0.92. All domains had reliability that was rated as moderate to strong by ICC, and the severity rating scale varied from 0.53 to 0.81. The Pearson correlation coefficient between KHQ and short form-36 (SF-36) in the majority of related areas was found to be weak to moderate, with values ranging from −0.27 to −0.53.

Conclusions:
The Marathi version of the KHQ was translated and adapted for use in Marathi language-speaking Indian women with urinary incontinence complaints. It represents an important instrument for the evaluation of incontinent women in clinical research with good interrater reliability and validity with SF-36 quality-of-life measure.
Clinical study of steroid receptors in nonmuscle invasive bladder cancer: A domain worth revisiting
Authors: Sharma Aditya Prakash , Singh Puranjay Pratap , Chauhan Rohit , Panda Ipsita , Devana Sudheer Kumar , Bora Girdhar S. , Mavuduru Ravimohan Suryanarayan , Kakkar Nandita , Kumar Santosh , Mete Uttam 
Published: April 2024

ABSTRACT

Introduction:
The prognostic significance of steroid receptors in bladder cancer remains controversial. This study was designed to determine the expression status of androgen receptor (AR), estrogen receptors (ERα and Erβ), and its potential role in predicting survival in patients with nonmuscle invasive bladder cancer (NMIBC).

Methods:
Sixty patients of NMIBC were screened and 57 (41 males and 16 females) were included in our study. The tissue microarray slides were evaluated by pathologists blinded to the clinical information. Association of distribution of steroid receptors with stage, grade, progression, and recurrence was seen.

Results:
The mean age of the population was 60.9 ± 9.3 years. Pathologically, majority of the patients were Ta (Ta: T1 stage 61.4% vs. 38.6%). Nine (15.8%) of the tumors stained positive for AR while one (1.8%) tumor stained positive for ERα and 36 (63.2%) tumors stained for ERβ. A higher proportion of male NMIBC stained positive for AR (19.5% vs. 6.2%, P = 0.420) while ERβ positivity was higher in females (58.5% vs. and 75%,P = 0.247). AR-negative tumors showed higher recurrence (20/48%–42%) as compared to AR-positive tumors (2/9%–22%). ERβ-positive tumors showed higher recurrence (15/36%–42% vs. 7/21%–33%, P = 0.179). Progression-free survival (PFS) was found to be significantly lower for ERβ-negative group (log-rank test P = 0.035).

Conclusion:
AR and ERβ positivity is found in NMIBC patients while ERα shows minimal staining in NMIBC patients. Although it did not reach a statistical significance, a higher proportion of AR-negative and ERβ-positive tumors recurred as compared to AR-positive and ERβ-negative patients. PFS was significantly lower in ERβ-negative group. Further exploratory studies on larger sample sizes are required to validate these findings in NMIBC patients.
ANALISIS MODEL ALTMAN Z-SCORE TERHADAP INDIKASI FINANCIAL DISTRESS PADA PERUSAHAAN MANUFAKTUR SUB SEKTOR KOSMETIK DAN KEPERLUAN RUMAH TANGGA YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Putri Putri , Munawaroh Munawaroh , Rustandi Tata 
Published: April 2024

This study aims to determine the indication of financial distress using the calculation of the Altman Z-Score model in manufacturing companies in the cosmetics and household utilities sub-sector listed on the Indonesia Stock Exchange for the 2018-2022 period. This study will use descriptive research methods with a qualitative approach using research objects, namely as many as 6 manufacturing companies in the cosmetics and household utilities sub-sector listed on the Indonesia Stock Exchange. The results showed that PT. Martina Berto Tbk with an average Z-Score obtained in 2018-2022 of 0.338 (Distress Zone), which means that the company is in a condition of financial distress. Companies with the category of being in standard financial condition (Grey Zone) with an average Z-Score value , namely PT. Mustika Ratu Tbk amounted to (2,642), and PT. Kino Indonesia Tbk amounted to (1,898). While PT. Unilever Indonesia Tbk (3,259), PT. Akasha Wira International Tbk (3,981), and PT. Mandom Indonesia (4,896) shows the average Z-Score in a healthy financial condition (Safe Zone). The conclusion in this study is that the Altman Z-Score model can be used to calculate an indication of the level of financial distress in a company. The results of the calculation analysis of the Altman Z-Score model of companies that are indicated to have financial difficulties are PT. Martina Berto Tbk. Policy carried out by PT. Martina Berto Tbk is business transformation, increasing marketing and promotion, expanding distribution cooperation, and divesting assets. The impact of this policy is that in 2021 the company recorded positive performance improvements
ERCP SONRASI PANKREATİT İLE PREOPERATİF DÖNEMDE BAKILAN LABORATUAR PARAMETRELERİNİN İLİŞKİSİ
Authors: Önem Soner , Dolu Süleyman , Camcı Mehmet , Yüksel Arif 
Published: April 2024

Amaç: ERCP öncesinde bakılan laboratuar tetkikleri ile post-ERCP pankreatit ilişkisinin araştırılması
Araçlar ve Yöntem: İzmir Bozyaka Eğitim Araştırma Hastanesinde Mart 2015- Haziran 2016 tarihleri arasında yapılan ERCP işlemleri retrospektif olarak incelendi. ERCP yapılan hastaların yaşı, cinsiyeti, ERCP endikasyonları, ERCP sırasında yapılan işlemler, işlem sonrası oluşan komplikasyonlar belirlendi. Hastaların işlem öncesinde bulunan hastaların beyaz küre, nötrofil, lenfosit, hemoglobin, trombosit, INR, AST, ALT, ALP, GGT, total bilirubin, albumin, LDH değerleriyle post-ERCP pankreatit ilişkisi araştırıldı.
Bulgular: Hastaların işlem öncesi bakılan laboratuar parametrelerinden GGT ve AST seviyesi ise pankreatit geçiren hastalarda, geçirmeyenlere oranla düşüktü. (GGT p=0.001, AST p=0.006). Diğer parametrelerde ise anlamlı fark saptanılmadı.
Sonuç: Post-ERCP pankreatit ERCP’nin en sık görülen komplikasyonudur. Pankreatit gelişimi açısından risk faktörleri bulunan hastaların tespiti erken tanı ve tedavi açısından önem taşımaktadır. AST düzeyinin normal üst sınırından 1.5 kat ve GGT düzeyinin 4 kattan düşük olması pre-operatif pankreatit risk değerlendirmesinde kullanılabilir.
Pharmacophore-based virtual screening of bioactive peptides as dipeptidyl peptidase 4 inhibitor for type 2 diabetes mellitus drug candidates
Authors: Muttaqin Fauzan Zein , Rhamadianto Muhamad Iqbal , Jafar Garnadi , Ruswanto  , Patonah  
Published: April 2024

Background: Diabetes is a chronic disease characterised by high blood sugar levels. Glucose that accumulates in the blood without being properly absorbed by the body's cells can cause various organ problems. If diabetes is not properly controlled, various complications can occur that endanger the life of the affected person.
Objective: To find bioactive peptides that have the potential to inhibit di-peptidyl peptidase 4 (DPP-4) enzyme as anti-diabetes drug candidates.
Method: This research was carried out using pharmacophore-based virtual screening.
Result: The validation of the pharmacophore-based virtual screening method showed that model III, which had five pharmacophore features consisting of three Pi interactions, one hydrogen bond donor, and three hydrogen acceptors, was the best pharmacophore model with the values of AUC 0.59; EF 1.2; Se 0.69; Sp 0.94; ACC 0.84; Ya 0.06; and GH 0.2. The screening of the 168,400 short-chain peptides using validated pharmacophore model III gave 51 tetrapeptides as the hits compounds with a pharmacophore fit score of more than 50.0%.
Conclusion: In total, 51 tetrapeptides were enlisted as potential as anti-diabetes mellitus drug candidates.
Adherence of HIV/AIDS patients to clinical outcome in Semarang City
Authors: Sabiti Farroh Bintang , Arief Thendi Abdul , Sofa Nada Aini , Saputra Rendi Adi , Aryani Iga Citra , Nastiti Nindita Sari , Faizatun Arvin 
Published: April 2024

Background: The success of HIV therapy can be measured by clinical, immunological, and virological monitoring. Meanwhile, low adherence to antiretroviral therapy (ART) contributes significantly to the disease progression and emergence of drug-resistant HIV.
Objective: This study aimed to determine the correlation between the adherence of HIV/AIDS patients to clinical outcomes in Semarang.
Method: This was an observational and cross-sectional approach. The instrument used the Simple Medication Adherence Questionnaire (SMAQ), which was validated and distributed to 50 respondents. The data were analyzed using chi-square (p < 0.05), and the results showed a statistically significant relationship.
Result: Respondents were male (96%), aged 26-45 years (76%), high school graduates (24%), working (88%), single (86%), without comorbidity (86%), length of treatment more than 12 months (80%), and general treatment (50%). A total of 31 respondents (62%) adhered to treatment with the combination regimen of Tenofovir/Lamivudine/Efavirenz (20%). There was a significant relationship (p = 0.006) between the length of treatment and patient adherence. The adherence results were not significantly related (p > 0.05) to virological outcomes.
Conclusion: There is no significant relationship between the adherence of HIV/AIDS patients and clinical outcomes.
Formulation and effectiveness of solid soap preparations from citronella grass (Cymbopogon nardus L.) essential oil extract against Listeria monocytogenes
Authors: Jayadi Lukky , Kesuma Sandry , Wattiheluw Muhammad Hasan , Widayanti Elok , Sabila Nurma , Widwiastuti Hanandayu , Asworo Riska Yudhistia , Ikayanti Retno 
Published: April 2024

Background: The components of essential oils, such as citronellol, citronellal, and geraniol have been reported to possess the ability to inhibit bacteria. Furthermore, Listeria monocytogenes is a bacteria that often affects humans and its infections can cause meningitis and bacteremia. In pregnant women, Listeria monocytogenes can cause flu-like syndrome with complications of miscarriage, infant death, and meningitis in infants.
Objective: This study evaluated the suitability of solid soap preparations from Citronella grass essential oil, based on its physical properties, such as organoleptic tests, as well as assessments of chemical tests and the effectiveness of the sample produced against bacteria.
Method: The soap-making process was initiated by mixing the fat fraction (stearic acid and coconut oil) with an alkali, namely 30% NaOH. The soap stock was then added to the other ingredients and stirred until it became homogeneous for testing.
Results: The test showed a pH value, water content, total fat, ethanol insoluble material, free fatty acids, chloride content, and unsaponificable fat of 10.8, 14.26, 74.84, 2.4, 0.26, 0.48, and 85.8, respectively. Furthermore, the sample showed a high level of inhibition against Listeria monocytogenes.
Conclusion: Evaluation of citronella essential oil extract soap met the requirements, except for its unsaponifiable fat.
Analysis of total flavonoid and antioxidant activity of coconut shell liquid smoke (Cocos nucifera L.) as an antibacterial
Authors: Masfria  , Syahputra Hafid , Wahyuni Henny Sri , Zebua Nilsya Febrika , Elizabeth  , Marcelynn  
Published: April 2024

Background: Coconut shell is often used for cooking or treated as waste. Liquid smoke is a by-product of coconut shell processing, which results from condensation of combustion steam. It is divided into grades one, two, and three based on the characteristics and utilisation. It contains phenolic, carbonyl acids and other compounds which act as antioxidants, antibacterials, and antifungals.
Objective: To determine the total content of flavonoids, antioxidants and antibacterial activity in liquid smoke.
Method: Liquid smoke was produced by a pyrolysator and distilled to produce grades one, two and three. It was then tested for antibacterial activity using the minimal inhibitory concentration (MIC) method against S. aureus and E. coli. The AlCl3 reagent and DPPH method were used to determine the total flavonoid and antioxidant levels, respectively.
Results: The MIC of grade one, two, and three coconut shell liquid smoke was 10%; 10%; 5% against S. aureus; and 10%, 5%, and 5% against E. coli. The total flavonoid yields from grades one, two and three were 0.0041, 0.0174, and 0.2741 mg QE/ml, respectively. Test results for antioxidant grades with IC50 values were 142.82, 121.64, and 90.80 µg/mL.
Conclusion: Coconut shell liquid smoke has antibacterial activity, contains a certain amount of flavonoids, and also possesses antioxidant activity.
The implementation of the CDS-quiz, a novel educational method, in augmenting the knowledge and competence of pharmaceutical technical personnel
Authors: Widyaningrum Naniek , Sofa Nada Aini , Winarsih Serina Salmathifa , Oktasari Masita 
Published: April 2024

Background: Pharmaceutical personnel are crucial to therapy implementation within healthcare facilities. The predicament lies in optimising the role of pharmaceutical technical staff within clinical pharmacy services, acting as a support system for pharmacists. The impediment to achieving higher satisfaction is attributable to pharmaceutical personnel's inadequate knowledge and skills. Therefore, a need arises for an efficient educational method to enhance their knowledge and proficiency.
Objective: To examine the implementation of the CDS-Quiz for enhancing patient knowledge and satisfaction.
Method: Over 90 day-research was conducted employing ceramah-, discussion-, and skill-quiz (CDS-Quiz). The respondents consisted of ten PTPs in healthcare facilities. The assessment of patient contentment was undertaken before and following the intervention.
Result: After implementing the CDS-Quiz, there was a statistically significant enhancement in PTPs’ knowledge and proficiency (p < 0.001). These include a substantial upswing in patient contentment levels concerning reliability (68.8% to 89.6%), responsiveness (71.1% to 88.8%), and empathy (81.2% to 92.6%) in the provision of pharmaceutical services within the healthcare facility. There was also an increase in assurance (88.2% to 95.5%) and tangible (86% to 91.7%).
Conclusion: The CDS-Quiz method proved the enhancement of the knowledge and skills of PTPs in healthcare services and can be applied to maximise pharmaceutical services.
Synthesis, and molecular docking of thiourea derivatives as antibacterial agents targeting enzymes involved in biosynthesis of bacterial cell wall
Authors: Suzana  , Diyah Nuzul Wahyuning , Susanti Rini , Najati Fika Amalia , Ekowati Juni , Budiati Tutuk 
Published: April 2024

Background: New antibacterials are needed due to the increasing resistance of bacteria to existing antibiotics. Thiourea derivative compounds (benzoylthiourea and 1,3-dibenzoylthiourea) contain aromatic groups, thio groups (C=S), and amide groups (H2N-C=O), which are commonly found in the class of antibacterial drugs. Molecular docking can be used to predict their antibacterial activity.
Objective: This study aimed to synthesise thiourea derivatives and predict their antibacterial activity by in silico method.
Methods: Synthesis was performed using nucleophilic substitution reactions. The synthesised compounds were identified using UV-Vis, FT-IR, and 1H-NMR. Molecular docking was conducted using the MOE program ver 2022.02.
Results: Benzoylthiourea (BTU) and 1,3-dibenzoylthiourea (DBTU) compounds were obtained with yields of 36.55% and 12.68%, respectively. The melting point 171-173°C for BTU and 202-204°C for DBTU. Molecular docking results showed higher binding affinity of DBTU against PBP2a (docking score < -5.75 kcal/mol) and FaBH (docking score <-4.7935 kcal/mol) compared to the corresponding native ligands, while the two compounds had lower affinity for the muramyl ligase.
Conclusion: BTU and DBTU can be synthesised by nucleophilic substitution reactions. DBTU is predicted to exhibit antibacterial activity against Methicilin Resistant Staphylococcus aureus (MRSA) and Mycobacterium tuberculosis.