bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative study of journal article scholarly activity: Pharmacy practice dual‐degree faculty versus single terminal‐degree faculty members
Authors: Henkels Rebecca , Tak Casey , Kim Kibum , Zhu Julia , Chao Darin , Munger Mark A. 
Published: March 2024

AbstractObjectiveThe goals of the 2005 National Institutes of Health (NIH) Roadmap of the Future of Pharmacy Colleges emphasized the importance of bidirectional information flow in translational research to enhance drug discovery and research. Many dual‐degree programs and pathways have been developed to meet this bidirectional information flow to enhance discovery and research, but limited data exists on the bibliometrics of these dual‐degree Department of Pharmacy Practice faculties. To determine whether dual‐degree programs enhance research, a four‐outcome bibliometric analysis of United States Departments of Pharmacy Practice tenure‐track (DPP‐TT) dual‐degree compared with DPP‐TT single terminal‐degree faculty was conducted over a 10‐year period.MethodsA search of PubMed of DPP‐TT single and dual‐degree faculty from January 10, 2010 to December 31, 2019 was performed. Faculty employed in DPP‐TT were determined through published rosters in the American Association of Colleges of Pharmacy (AACP) rosters or college/school internet sites. Department of Pharmacy Practice faculty members' number of publications, number of citations per publication, h‐index, and NIH iCite weighted Relative Citation Ratio (RCR) value were determined. Descriptive statistics and analysis of variance compared dual‐degree with single terminal‐degree DPP faculty data.ResultsNinety‐one institutions employed 348 DPP‐TT dual‐degree faculty that produced 7480 publications compared with 131 institutions with 1805 single terminal‐degree faculty of 12 670 publications. Dual‐degree DPP number of citations per publication (mean ± standard deviation [SD]) was 37.8 ± 86.8 with a journal impact factor (JIF) of 6.4 ± 14.3 compared to single‐degree of 24.7 ± 90.8 (p < 0.001) with a JIF of 4.7 ± 80.8 (p < 0.001). Dual‐degree faculty h‐index was 14.7 ± 12.5 with a mean iCite weighted RCR of 54.8 ± 87.6 compared to single‐degree faculty of 6.5 ± 8.9 (p < 0.001) with an RCR of 22.1 ± 65.3 (p < 0.001).ConclusionDepartment of Pharmacy Practice dual‐degree faculty have significantly higher bibliometrics compared with single‐degree DPP faculty.
Synergistic regulation of chloride anion recognition using a triple‐functional sites receptor with two different cationic effectors
Authors: Yao Qingqing , Yuan Kun , Li Mengyang , Zhao Yaoxiao , Liu Yanzhi , Zhao Xiang 
Published: March 2024

AbstractThe synergistic regulation of the multi‐functional sites on one receptor molecule with different cationic effectors for anion recognition is scarce to be well understood from the experiment and theory. In this work, a new anion receptor with three functional zones including ether hole, biurea and double bipyridine groups (EUPR) is designed expecting to enhance the chloride anion recognition together with a rational synthesis path being proposed based on four simple and mature organic reaction steps. The conformational structures of the designed receptor EUPR and the binding behaviors for three kinds of ions (Cl−, Na+, and Ag+) are deeply investigated by using density functional theoretical calculations. It is found that Cl− binding via the hydrogen bond interaction can be significantly enhanced and synergistically regulated by the two kinds of cations and the corresponding conformational changes of receptor EUPR. Especially, the conformational pre‐organization of receptor caused by the encapsulation of sodium ion into ether hole is benefit to the binding for Cl− in both thermodynamics and kinetics. Na+ binding, in turn, can ever be enhanced by chloride anion, whereas it seems that Ag+ binding cannot always be enhanced by chloride anion, reflecting an electrical complementary matching and mutual enhancement effect for different counter ions. Moreover, solvent effect calculations indicate that EUPR may be an ideal candidate structure for Cl− recognition by strategy of counter ion enhancement in water. Additionally, a visual study of intermolecular noncovalent interaction (NCI) and molecular electrostatic potential (ESP) are used for the analysis on the nature of interactions between receptor and bound ions.
Using Real‐World Data to Externally Evaluate Population Pharmacokinetic Models of Dexmedetomidine in Children and Infants
Authors: McCann Sean , Helfer Victória E. , Balevic Stephen J. , Hornik Chi D. , Goldstein Stuart L. , Autmizguine Julie , Meyer Marisa , Al‐Uzri Amira , Anderson Sarah G. , Payne Elizabeth H. , Turdalieva Sitora , Gonzalez Daniel ,   the Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee
Published: March 2024

AbstractDexmedetomidine is a sedative used in both adults and off‐label in children with considerable reported pharmacokinetic (PK) interindividual variability affecting drug exposure across populations. Several published models describe the population PKs of dexmedetomidine in neonates, infants, children, and adolescents, though very few have been externally evaluated. A prospective PK dataset of dexmedetomidine plasma concentrations in children and young adults aged 0.01‐19.9 years was collected as part of a multicenter opportunistic PK study. A PubMed search of studies reporting dexmedetomidine PK identified five population PK models developed with data from demographically similar children that were selected for external validation. A total of 168 plasma concentrations from 102 children were compared with both population (PRED) and individualized (IPRED) predicted values from each of the five published models by quantitative and visual analyses using NONMEM (v7.3) and R (v4.1.3). Mean percent prediction errors from observed values ranged from −1% to 120% for PRED, and −24% to 60% for IPRED. The model by James et al, which was developed using similar “real‐world” data, nearly met the generalizability criteria from IPRED predictions. Other models developed using clinical trial data may have been limited by inclusion/exclusion criteria and a less racially diverse population than this study's opportunistic dataset. The James model may represent a useful, but limited tool for model‐informed dosing of hospitalized children.
Contrast‐enhanced ultrasound of polyp malignant transformation with multiple metastases in a patient with Peutz‐Jeghers syndrome
Authors: Wang Xiangyu , Zhang Longfang , Qiao Huilian , Liu Xi , Fan Xiaozhou 
Published: March 2024

AbstractMulti‐systemic metastasis in patients with Peutz‐Jeghers syndrome (PJS) is very rare, and there are nearly no relevant imaging reports, especially in contrast‐enhanced ultrasound (CEUS). We present here a 40‐year‐old male patient who underwent several partial small bowel resections and endoscopic polypectomy for intestinal polyps. After reviewing the patient's clinical diagnosis and treatment process, CEUS with sulfur hexafluoride microbubbles (SonoVue, Bracco, Milan, Italy) in the liver and gastrointestinal tract was performed. We imaged multiple abnormal masses with sonographic features consistent with malignancies. Combined with other imaging examinations and 18 gauge core‐needle puncture biopsy of liver masses, multiple metastases outside the gastrointestinal tract were considered. This case report suggests CEUS may be an easy, effective, and supplementary method for evaluating PJS patients with suspected multi‐systemic malignant lesions including the gastrointestinal tract.
Student training in administering inferior alveolar nerve block anesthesia with a simple manufactured simulation model
Authors: Garcia‐Blanco Matias , Ruffini Juan M. , Salomone Lorena , Gualtieri Ariel F. , Puia Sebastian A. 
Published: March 2024

AbstractObjectiveTo compare the effectiveness of administering inferior alveolar nerve blocks (IANB) for the first time with or without a previous practical lesson using a simple manufactured simulator.MethodsThis was a study designed to compare students’ first administration of IANB anesthesia during 2022, with or without a previous practical lesson. Students were randomized into two groups. The experimental group attended both theoretical lessons and a practical lesson with a simulator device, while the control group attended only theoretical lessons. The theoretical lesson included usual contents such as anatomy, physiology, technical maneuvers for administering anesthesia, tips, and complications, and the practical lesson consisted of the administration of anesthesia using a simple manufactured simulator. After students applied their first IANB, its efficacy, and their answers to a questionnaire on a 5‐point Likert scale were recorded. Statistical analysis consisted of the Chi‐square test (p < 0.05).ResultsThe study recorded 60 anonymous surveys. The main difference observed was in instrument handing (p < 0.05), and there was a tendency in the ease of recognition of the anatomical marks used for the technique—pterygomandibular raphe and coronoid notch of the mandible (p = 0.08 and 0.11, respectively). No difference in success was observed (p > 0.05). Self‐confidence and personal feelings did not differ statistically. All students agreed strongly or partially that training with the simulator model was helpful.ConclusionStudents who used simple manufactured simulators achieved better outcomes for instrument handling, and possibly for identification of anatomical landmarks, than those who received only theoretical lessons.
Patterns of integrated growth of body parts in Rook (Corvus frugilegus) ontogeny
Authors: Shatkovska Oksana V. , Ghazali Maria , Mytiai Ivan S. , Stegney Mykola M. 
Published: March 2024

AbstractThe early period of ontogeny is key to understanding the patterns of body plan formation in birds. Most studies of avian development have focused on the development of individual avian characters, leaving their developmental integration understudied. We explored the dynamics and integration of relative percentage increments in body mass, lengths of head, skeletal elements of wing and leg, and primary flight feathers in the embryonic and postnatal development of the Rook (Corvus frugilegus). The relative percentage increments were calculated according to Brody's equation. Groups of similar growing traits (modules) were determined using hierarchical cluster analysis, and the degree of correlation between modules was estimated by PLS analysis. The embryonic and postnatal periods demonstrate significant consistency both in the dynamics of changes in relative percentage increments of studied traits as well as in the clustering of individual modules. The modules mainly include the body mass and head length, as well as the elements that form the fore‐ and hind limbs. Differences were revealed in the combination of modules into clusters in embryonic and postnatal periods. Hind limb elements clustered together with wing elements in the embryonic period but with body mass and the head in the postnatal period. The strongest modularity was noted for the leg in embryogenesis, and for the wing in postnatal development. The forelimb and especially the primary feathers had more distinctive growth patterns. We suggest the changes in the degree of integration between locomotor modules in ontogenesis are connected with the earlier functioning of the legs in the postnatal period and with the preparation of the wings for functioning after a chick leaves the nest.
Patients' Experience to MRI Examinations—A Systematic Qualitative Review With Meta‐Synthesis
Authors: Nieto Alvarez Isabel , Madl Janika , Becker Linda , Amft Oliver 
Published: March 2024

BackgroundPatients often mention distress, anxiety, or claustrophobia related to MRI, resulting in no‐shows, disturbances of the workflow, and lasting psychological effects. Patients' experience varies and is moderated by socio‐demographic aspects alongside the clinical condition. While qualitative studies help understand individuals' experiences, to date a systematic review and aggregation of MRI individuals' experience is lacking.PurposeTo investigate how adult patients experience MRI, and the characterizing factors.Study TypeSystematic review with meta‐aggregation and meta‐synthesis.Population220 patients' reported experience of adults undergoing clinical MRI and 144 quotes from eight qualitative studies.AssessmentSystematic search in PubMed, Scopus, Web of Science, and PsycInfo databases according to the PRISMA guidelines. For quality appraisal, the Joanna Briggs Institute (JBI) tools were used. Convergent segregated approach was undertaken.Data AnalysisParticipant recruitment, setting of exploration, type of interview, and analysis extracted through Joana Briggs Qualitative Assessment and Review Instrument (JBI QARI) tool. Meta‐synthesis was supported by a concept map. For meta‐aggregation, direct patient quotes were extracted, findings grouped, themes and characterizing factors at each stage abstracted, and categories coded in two cycles. Frequency of statements was quantified. Interviews' raw data unavailability impeded computer‐aided analysis.ResultsEight articles out of 12,755 initial studies, 220 patients, were included. Meta‐aggregation of 144 patient quotes answered: (1) experiences before, at the scanning table, during, and after an MRI, (2) differences based on clinical condition, and (3) characterizing factors, including coping strategies, look‐and‐feel of medical technology, interaction with professionals, and information. Seven publications lack participants' health literacy level, occupation, and eight studies lack developmental conditions, ethnicity, or country of origin. Six studies were conducted in university hospitals.Data ConclusionAggregation of patients' quotes provide a foundational description of adult patients' MRI experience across the stages of an MRI process. Insufficient raw data of individual quotes and limited socio‐demographic diversity may constrain the understanding of individual experience and characterizing factors.Level of Evidence1Technical EfficacyStage 5
Concentrations of per‐ and polyfluoroalkyl substances in vegetables from Sydney and Newcastle, Australia
Authors: Liu Siyuan , Duan Luchun , Shi Feng , Filippelli Gabriel M , Naidu Ravi 
Published: March 2024

AbstractBACKGROUNDThis study investigated per‐ and polyfluoroalkyl substances (PFASs) in 53 fruit and vegetable samples collected from a local wholesale and retail market in Sydney and a local supermarket in Newcastle. As there is limited information about PFAS levels in vegetables on the market, this study aimed to fill this gap and assess potential risks for humans through consumption of these vegetables.METHODSQuEChERS extraction – a solid‐phase extraction method, a portmanteau word formed from ‘quick, easy, cheap, effective, rugged and safe’ – followed by enhanced matrix removal–lipid cleaning and liquid chromatography–tandem mass spectrometry analysis were used to detect 30 PFASs in vegetables.RESULTSPFOA was detected in 7 out of the 53 samples, with concentrations of 0.038–1.996 ng g−1 fresh weight; PFOS was detected in 2 samples only, with concentrations ranging from 0.132 to 0.911 ng g−1 fresh weight. PFHxS was not detected in any sample in this study. PFOA and PFOS concentrations measured in vegetables in this study constituted daily intake of 2.03 ng kg−1 body weight (BW) and 1.98 ng kg−1 BW, respectively, according to recommended daily vegetable intake and BW data from the Australian Bureau of Statistics. The most sensitive population group is girls of 4–8 years of age. These estimated exposure levels represent up to 1.3% of the tolerable daily intake for PFOA (160 ng kg−1 BW) and 9.9% for PFOS (20 ng kg−1 BW) according to Food Standards Australia New Zealand. Consumption of the vegetables from the study locations poses a marginal risk to human health. © 2024 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Research progress on natural preservatives of meat and meat products: classifications, mechanisms and applications
Authors: Wen Lei , He Hongjun , Liu Yaobo , Wang Weiting , Du Pengfei , Hu Peng , Cao Jianfang , Ma Yanli 
Published: March 2024

AbstractMeat and meat products are highly susceptible to contamination by microorganisms and foodborne pathogens, which cause serious economic losses and health hazards. The large consumption and waste of meat and meat products means that there is a need for safe and effective preservation methods. Furthermore, toxicological aspects of chemical preservation techniques related to major health problems have sparked controversies and have prompted consumers and producers to turn to natural preservatives. Consequently, natural preservatives are being increasingly used to ensure the safety and quality of meat products as a result of customer preferences and biological efficacy. However, information on the current status of these preservatives is scattered and a comprehensive review is lacking. Here, we review current knowledge on the classification, mechanisms of natural preservatives and their applications in the preservation of meat and meat products, and also discuss the potential of natural preservatives to improve the safety of meat and meat products. The current status and the current research gaps in the extraction, application and controlled‐release of natural antibacterial agents for meat preservation are also discussed in detail. This review may be useful to the development of efficient food preservation techniques in the meat industry. © 2024 Society of Chemical Industry.
Application of a Novel 3D‐Printed Nasal Plug as a Conservative Treatment for Empty Nose Syndrome
Authors: Gwak Jang Wook , Kim Don‐Han , Jang Yong Ju 
Published: March 2024

ObjectiveEmpty nose syndrome (ENS) is commonly treated by surgery, albeit with limited success. Herein, we introduce our experience of applying a newly developed “3D‐printed nasal plug” as an alternative conservative treatment modality.MethodsThis retrospective study included 20 patients (14 males, 6 females; mean age 46.5 ± 13.5 years) with ENS who underwent the application of the 3D‐printed nasal plug at Asan Medical Center between June 2022 and May 2023. Symptom improvement was assessed by Empty Nose Syndrome 6‐Item Questionnaire (ENS6Q) before and after applying the nasal plug. Clinical results, such as duration and frequency of plug use, discomfort, and level of satisfaction, were investigated.ResultsThe mean follow‐up duration was 40.3 ± 24.2 weeks. The average duration of nasal plug usage was 10.8 h per day and 5.3 days a week. The ENS6Q scores improved from 19.6 ± 4.6 to 6.8 ± 5.1 (mean reduction 12.8 ± 5.9) after 30 minutes of wearing. Symptom “nose feelings too open” was improved most by a score of 3.0 ± 1.5 (p < 0.001). Thirteen patients (65.0%) reported that the effectiveness of the plug, initially confirmed at the first wearing, was well maintained during the entire follow‐up. Four patients (20.0%) wore the nasal plug uninterruptedly throughout the week, whereas nine patients (45.0%) wore it intermittently as needed. Frequently reported complaints with plug usage were ‘displacement of the plug’ and ‘cosmetic concerns’ about the visible hook portion.ConclusionA 3D‐designed nasal plug can be a useful conservative treatment option for ENS patients.Level of Evidence4 Laryngoscope, 134:3935–3940, 2024
An improved method to quantify bulk carbohydrate in marine planktonic samples
Authors: Hu Ying‐Yu , Irwin Andrew J. , Finkel Zoe V. 
Published: March 2024

AbstractThe TPTZ (2,4,6‐tripyridyl‐s‐triazine) method is used to detect monosaccharides from seawater and particulate matter samples because it is sensitive, precise, rapid and easy to perform. Contrary to mechanisms proposed in the literature, we provide evidence that the TPTZ method detects hydroxyl as well as aldehyde groups in monosaccharides when all reducing groups are fully deprotonated in alkaline medium. We use this insight to develop an optimized hydrolysis protocol to increase yields from polysaccharides while minimizing the dehydration of monosaccharides. Compared to the TPTZ method with commonly used hydrolysis protocols and the often‐used phenol–sulfuric acid method, our new optimized method detects a wider range of carbohydrates with a more consistent yield relative to glucose and much lower coefficient of variation. When applied to phytoplankton cultures and marine particulate samples, our new method achieves significantly higher bulk carbohydrate yields.
Suitability of using simulated porous‐like solutions to evaluate the steel corrosion in carbonated concrete
Authors: Carricondo Juan , Duffó Gustavo S. , Farina Silvia B. 
Published: March 2024

AbstractThe use of simulated solutions is a common practice in corrosion studies to assess easily and quickly the corrosion behaviour of materials in real situations. In this context, it is frequent to substitute tests performed in concrete or mortar with tests performed in porous‐like solutions. Particularly, to simulate carbonated concrete, different carbonated porous‐like solutions (CPS) are found in the literature. However, it is not known whether the use of these solutions accurately predicts the behaviour of steel bars embedded in carbonated concrete. In the present work, a comparison between the corrosion behaviour of carbon steel in carbonated mortar and in different CPS was performed. It was found that none of the CPS studied in the present work adequately simulate the corrosion behaviour of the steel in carbonated mortar, but the CPS containing high concentrations of carbonates/bicarbonates is the only one that provides corrosion rates close to those obtained in carbonated concrete.
Flow Behavior of Entangled Polymer Nanoparticle Composites in a Nanotube: Insights into Jamming State
Authors: Liu Hu , An Lijia , Ruan Yongjin , Lu Yuyuan 
Published: March 2024

AbstractUsing molecular dynamics simulations, this study investigates the equilibrium properties and flow behaviors of entangled polymer nanoparticle composites (PNCs) within a nanotube. The results show that the density distribution of nanoparticles (NPs), displacement of polymer chains and NPs, and the moduli of PNCs remain relatively unaffected when NP volume fractions (ΦN) ≤0.10. However, the flow behavior of entangled PNCs deviates from the ideal parabolic profile seen in unentangled PNCs, displaying plug‐like flow characteristics with a significant platform region, indicating the presence of shear bands. Interestingly, entangled PNCs at intermediate ΦN values undergo a significant alteration in NP distribution under steady flow, resulting in notable NP aggregation. At ΦN = 0.30, a distinct change in the static structure of PNCs occurs, reducing the equilibrium distance between neighboring NPs. Consequently, the motion of both polymer chains and NPs becomes restricted, leading to an increase in the moduli of PNCs resembling solid‐like behavior. Additionally, the entangled PNCs experience a complete absence of flow, indicating the entry into a jamming state. This study contributes to the understanding of PNCs flow behavior and provides insights into fundamental aspects and practical implications of PNCs.