bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone-anchored prostheses for transfemoral amputation: a systematic review of outcomes, complications, patient experiences, and cost-effectiveness
Authors: Rehani Mayank , Stafinski Tania , Round Jeff , Jones C. Allyson , Hebert Jacqueline S. 
Published: April 2024

IntroductionBone-anchored prostheses (BAP) are an advanced reconstructive surgical approach for individuals who had transfemoral amputation and are unable to use the conventional socket-suspension systems for their prostheses. Access to this technology has been limited in part due to the lag between the start of a new procedure and the availability of evidence that is required before making decisions about widespread provision. This systematic review presents as a single resource up-to-date information on aspects most relevant to decision makers, i.e., clinical efficacy, safety parameters, patient experiences, and health economic outcomes of this technology.MethodsA systematic search of the literature was conducted by an information specialist in PubMed, MEDLINE, Embase, CINAHL, Cochrane Library, the Core Collection of Web of Science, CADTH's Grey Matters, and Google Scholar up until May 31, 2023. Peer-reviewed original research articles on the outcomes of clinical effectiveness (health-related quality of life, mobility, and prosthesis usage), complications and adverse events, patient experiences, and health economic outcomes were included. The quality of the studies was assessed using the Oxford Centre for Evidence-Based Medicine Levels of Evidence and ROBINS-I, as appropriate.ResultsFifty studies met the inclusion criteria, of which 12 were excluded. Thirty-eight studies were finally included in this review, of which 21 reported on clinical outcomes and complications, 9 case series and 1 cohort study focused specifically on complications and adverse events, and 2 and 5 qualitative studies reported on patient experience and health economic assessments, respectively. The most common study design is a single-arm trial (pre-/post-intervention design) with varying lengths of follow-up.DiscussionThe clinical efficacy of this technology is evident in selected populations. Overall, patients reported increased health-related quality of life, mobility, and prosthesis usage post-intervention. The most common complication is a superficial or soft-tissue infection, and more serious complications are rare. Patient-reported experiences have generally been positive. Evidence indicates that bone-anchored implants for prosthesis fixation are cost-effective for those individuals who face significant challenges in using socket-suspension systems, although they may offer no additional advantage to those who are functioning well with their socket-suspended prostheses.
A importância da escolha estratégica entre bulking e cutting na preparação do atleta de fisiculturismo
Authors: Almeida Marcos Paulo Nonato de , Silva Carla Dhuly 
Published: April 2024

A presente dissertação científica se dedica a compreender de modo amplo as principais carcteristicas inerentes ao processo de dieta preparatório na qual os atletas dedicados ao fisiculturismo competitivo aderem, em prol do aperfeiçoamento de sua musculatura. Destaca-se que essa dieta preparatória se desenvolve em duas etapas distintas nomeadas como Bulking e Cutting que respectivamente são marcadas por um período de forte ingestão calórica imediatamente seguido por uma fase de intensa restrição alimentar, tornando necessário o acompanhamento nutricional especializado a fim de evitar complicações médicas indesejadas. Para a elaboração desse estudo foi realizado um levantamento bibliográfico na qual reuniu-se um escopo documental proveniente de diversas fontes de pesquisa na qual se inclui-se textos elaborados por especialistas da área da nutrição bem como a consideração de profissionais dedicados à educação física. Em vista do estudo empreendido neste artigo foi possível expor os melhores caminhos para uma adequada maturação muscular bem como determinar os riscos inerentes de se empreender esse processo sem o devido cuidado.
Gestão das redes de atenção à saúde através da atenção básica no município de Teresópolis - potencialidades e fragilidades
Authors: Marques Claudia Cristina Dias Granito , Costa Carina da Silva Ferreira , Chaves Adriana Nunes 
Published: April 2024

Com o advento do Sistema Único de Saúde, houve uma mudança na assistência à saúde. Essa mudança requer a organização dos serviços em rede, abandonando o modelo fragmentado e verticalizado de atenção. A atenção básica desempenha um papel central na coordenação dessa rede, onde os diferentes pontos de atenção trabalham em articulação. O fluxo nessa rede é essencial para garantir que o usuário siga um itinerário contínuo, evitando a perda no caminho terapêutico e prevenindo agravos futuros à saúde. Os enfermeiros desempenham um papel de gestores e provedores de cuidados na operacionalização da rede de saúde. Para garantir um cuidado contínuo, abrangente, longitudinal e humanizado aos usuários, é imprescindível que os estes conheçam o sistema e sejam capazes de fortalecê-lo. Analisar a atuação dos enfermeiros na atenção primária, com ênfase nos indicadores de saúde e no fluxo da rede de atenção à saúde no município de Teresópolis - RJ. O estudo contou com uma linha de pesquisa de natureza básica, em abordagem qualitativa e descritiva tendo objetivo exploratório. Trata-se de uma pesquisa de campo com desenvolvimento no tempo de forma longitudinal. Foram contempladas dez das 26 unidades de atenção básica do município. contando com a participação de 10 enfermeiros, que assinaram o Termo de Consentimento Livre e Esclarecido. A referida pesquisa teve início após a aprovação da Plataforma Brasil, no dia 28/03/2023 – CAAE: 67772223.0.0000.5247 e respeitou as normas estabelecidas pelas Resoluções nº 466/2012 e nº510/2016, a realização do estudo levou em consideração os aspectos bioéticos, éticos e legais da pesquisa envolvendo seres humanos, garantindo o anonimato, sigilo, beneficência e benevolência por meio do Termo de Consentimento Livre e Esclarecido (TCLE). A partir dos questionários foi realizada uma pré-análise dos conteúdos com uma leitura flutuante do material, com base na exaustividade, representatividade, homogeneidade e pertinência do conteúdo, formulação de hipóteses e de preparo do material; bem como, exploração do material/categorização do conteúdo obtido; por fim, o tratamento dos resultados. Para compreensão de o fluxo contínuo na rede de atenção à saúde através da assistência do enfermeiro, as seguintes categorias foram definidas: Perfil Sociodemográfico dos Enfermeiros; Rede de Atenção à Saúde; e, Sistema de Atenção à Saúde do Município de Teresópolis-RJ. Conclui-se que a realização de estratégias como educação continuada e permanente potente, são capazes de promover habilidades e competências, com vistas ao aperfeiçoamento e desenvolvimento do serviço em saúde, oportunizando ações transformadoras, com objetivo de prestar um cuidado transversal, compartilhado e integral em saúde aos indivíduos e população.
Vaginose bacteriana – avaliação da atividade antimicrobiana seletiva de gel de Schinus terebinthifolia raddi
Authors: Marques Carlos Alberto Sá , Henrique Paloma de Barros , Magalhães Haliny da Silva , Melo Tahira Souza , Mourad Amouni Mohmoud , Delorenzi Jan Carlo Morais Oliveira Bertassoni 
Published: April 2024

O microbioma vaginal sofre contínua flutuação durante o ciclo menstrual e após a menopausa. Albert Döderlein foi o primeiro a descrever sobre bactérias produtoras de ácido láctico na cavidade vaginal. Tais bactérias são capazes de inibir o crescimento de microrganismos anaeróbios e patogênicos. Quando há a redução desses lactobacilos, há proliferação de bactérias oportunistas como as do gênero Gardnerella. A vaginose bacteriana (VB) é uma patologia não sexualmente transmissível, caracterizada pelo aumento do número de bactérias anaeróbias e do pH vaginal, ocasionando um corrimento vaginal acinzentado e de odor fétido. A prevalência estimada é alta, no entanto a cura efetiva e duradoura é ainda incerta. Essa falha em tratar adequadamente tem motivado a busca de alternativas terapêuticas, que consigam tratar e prevenir as possíveis recidivas da patologia1. No Brasil, a espécie Schinus terebinthifolia Raddi (aroeira-da-praia) é bem conhecida, e um ensaio clínico mostrou sua atuação de forma eficaz no tratamento da VB, bem como a recomposição da microbiota vaginal. O presente estudo tem por objetivo determinar a capacidade do gel de Schinus terebinthifolia Raddi em inibir o crescimento dos microrganismos Lactobacillus gasseri ATCC 19992 e Gardnerella vaginalis ATCC 14018. Foram usados Lactobacillus gasseri ATCC 19992 e Gardnerella vaginalis ATCC 14018. As culturas de trabalho foram produzidas com incubação a 36°±1°C por 24 horas. Foram efetuados pequenos poços nas placas com meio de cultura, onde a amostra teste foi inoculada. As placas foram incubadas por 48 horas a temperatura de 30°C. Não foi observado halo de inibição contra L. gasseri, enquanto que foi observado halo de inibição contra G. vaginalis. Tais dados, demonstram que o gel de Schinus terebinthifolia Raddi tem ação anaerobicida contra um dos principais microrganismos causadores da VB e, ao mesmo tempo, não apresenta nenhuma alteração na formação das colônias de L. gasseri, um dos lactobacilos da microbiota vaginal.
El Fortalecimiento de las Instituciones Cartográficas en América Latina en el Marco del ODS 16. Instituciones Sólidas: eficaces, responsables e inclusivas
Authors: Sandoval Jorge Lescano , Sena Lucia Emperatriz Valdéz , Valdez Lucia Emperatriz Lescano , Velásquez Miguel Alva , García José Tomas Mendoza , Reyes Juan Carlos Urcariegui , Vega Marlitt Florinda Naupay 
Published: April 2024

Se propone fortalecer a las organizaciones cartográficas que hacen de ente rector en los diversos países de America del Sur, ello en el marco del Objetivo de Desarrollo Sostenible (ODS) 16: Paz, Justicia e Instituciones Sólidas. El fortalecimiento de estás organizaciones les permiten ser eficaces, responsables e inclusivas con una mayor participación del personal civil en la vida institucional. 06 países aún mantienen la gestión estricta militarizad y 05 están gestionados por civiles y militares. En el marco del ODS 16, se pretende una mayor democratización y asegurar su fortalecimiento, constituyéndolas como instituciones democráticas y eficaces y respondan al desarrollo sostenible, contando con una cartografía y datos geoespaciales de calidad al servicio de la sociedad.
Gestión de residuos sólidos: Una revisión documental
Authors: Velásquez-Pita Fanny Elizabeth , Olivera-Aldana Mario Félix , Diaz-Valiente Frank Alexander , Mantilla-Sevillano Jorge Edwin 
Published: April 2024

Se tiene por objetivo analizar la gestión de residuos sólidos desde una revisión documental. Se trabajó la metodología de investigación descriptiva. Se logró identificar el limitado conocimiento que tienen las autoridades municipales sobre gestión y el manejo de los RSD y RSND. Se necesita mejorar el proceso de la gestión de los RSD y RSND, a fin de brindar beneficios a la población en las zonas rurales y dispersas en el ámbito de los Tambos. Los Equipos Territorial MIDIS, deben acompañar y brindar asistencia técnica a los gobiernos locales para la implementación de las agendas en gestión, de los residuos sólidos, en el marco de las prioridades de la PNDIS, vinculándolas a los instrumentos de gestión de los gobiernos regionales con la finalidad de promover una adecuada gestión y manejo de residuos sólidos en el ámbito de los Tambos.
CORRELATION OF STRUCTURE AND FUNCTIONAL DEFECT WITH QUALITY OF LIFE IN PATIENT WITH GLAUCOMA
Authors: Rahma An Nazzila Meta , Jati Krisna Dwi Purnomo , Ekantini Retno , Gani Tatang Talka 
Published: April 2024

Introduction: Glaucoma damage generally produces a characteristic change in the morphology of the optic nerve, runs progressively and permanently that cause visual changes, decreased vision, and blindness. Blindness will affect one’s dependence to get help in their daily activities. This paper investigate the correlation between VFI, BCVA, MD and RNFL thickness with the quality of life of people with glaucoma using Glaucoma Quality of Life-15 (GQL-15).
Methods: A cross-sectional study conducted at the Sardjito Eye Center in April 2021. Purposive sampling used to recruit glaucoma patients who had BCVA, Visual Field examination (Humphrey Field Analyzer (HFA) 3 Carl Zeiss Meditec Inc.), and OCT ONH (Cirrus HD-OCT 5000, Carl Zeiss). Glaucoma Quality of Life-15 (GQL-15) questionnaire were used to interview the patients.
Results: Eight (32%) normotension glaucoma and 17 (68%) open angle glaucoma patients were included. Fifteen (60%) patients aged 17-40 y.o, 7 (28%) aged 41-60 y.o and 3 (12%) aged > 60 y.o were included. Majority of the samples 6 of them were unemployed (24%), 5 entrepreneurs 5 (20%) and 5 students (20%). GQL-15 score was significantly correlated with respondent's BCVA r= -0.39 (p= 0.05). However, there was no correlation between GQL-15 with RNFL r= 0.01 (p=0.94), VFI r= -0.21 (p= 0.29) and MD with r=0.09 (p= 0.66) respectively. It showed that VFI and GQL-15 has negative correlation with a correlation coefficient of -0.21 (p=0.29). Subscale score related to central and near was significantly correlated with VFI (p= 0,05) and MD (p= 0,03).
Conclusion: There was a significant correlation between GQL-15 subscale score of central and near vision with VFI and MD. Subjects with lower VFI and MD tend to have worse problem with central and near vision. Total GQL-15 score has a weak negative correlation with BCVA and MD. There was no correlation between GQL-15 with VFI and RNFL.
Polityka monetarna w ujęcia Keynesa i Friedmana
Authors: Zagóra-Jonszta Urszula 
Published: April 2024

CEL NAUKOWY: Celem artykułu jest porównanie podejścia do polityki pieniężnej dwóch najwybitniejszych ekonomistów XX w.: Miltona Friedmana i Johna Maynarda Keynesa.
PROBLEM I METODY BADAWCZE: W artykule wykorzystano metodę analizy prac obu ekonomistów, metodę porównawczą oraz prostą metodę opisową. Oparto się na oryginalnych pracach Keynesa i Friedmana oraz publikacjach innych współczesnych autorów.
PROCES WYWODU: Friedman był liberałem, wierzącym w sprawne funkcjonowanie mechanizmu rynkowego; Keynes zwolennikiem interwencjonizmu państwowego. Argumentacja obu ekonomistów w zakresie polityki monetarnej była wynikiem priorytetów, jakie stawiali przed polityką gospodarczą. Dla Keynesa najważniejsza była walka z bezrobociem, dla Friedmana – z inflacją. Dlatego Keynes preferował politykę fiskalną, jako skuteczniejszą w wyprowadzaniu gospodarki z kryzysu, Friedman zaś politykę monetarną nastawioną na przeciwdziałanie inflacji.
WYNIKI ANALIZY NAUKOWEJ: Stanowisko obu ekonomistów do polityki monetarnej było różne. Podkreślono aktualność podejścia keynesowskiego w latach ostatniego kryzysu finansowego. Po jego zakończeniu wrócono jednak do bardziej liberalnej polityki pieniężnej.
WNIOSKI, INNOWACJE, REKOMENDACJE: Artykuł stanowi przyczynek do badań nad współczesną teorią monetarną i wynikającą z niej polityką, prezentując dwie różne koncepcje.
Virtues and institutions as the foundations of a res publica in Wawrzyniec Goślicki and Gasparo Contarini
Authors: Pietrzyk-Reeves Dorota 
Published: April 2024

RESEARCH OBJECTIVE: The aim of this article is to examine and compare two republican approaches to politics and res publica presented in the sixteenth century by Wawrzyniec Grzymala Goślicki and Gasparo Contarini.
THE RESEARCH PROBLEM AND METHODS: Both authors define the core elements of a republican scientia civilis but emphasize different aspects as being of primary importance for a well‑ordered civitas libera. Goślicki saw the best safeguards of a free and well‑ordered commonwealth in the character and virtues of the rulers and citizens, whereas Contarini believed that such safeguards could only be found in a good legal and institutional structure that kept corruption at bay. The article follows the contextual method typical for intellectual history to present different arguments that Contarini and Goślicki formulated in their understanding of scientia civilis and the best commonwealth looking at both the context of their works and their arguments.
THE PROCESS OF ARGUMENTATION: After introducing the context for the two works the next two parts focus on Goslicki’s and then Contarini’s vision of scientia civilis and the most effective ways to keep corruption and decay at bay followed by comparison and conclusion.
RESEARCH RESULTS: A comparison of these two visions should shed some light on the later development of both polities and republicanism in modern Europe more generally which largely followed Contarini and not Goślicki. It can also provide an important lesson for our own understanding of politics and political philosophy that should underpin a political order to make it resilient to corruption and backsliding.
CONCLUSIONS, INNOVATIONS, AND RECOMMENDATIONS: Examining these two authors and their prominent works helps better situate political discourses in the two countries that explain different trajectories of their constitutions and political developments, and for us today provide an interesting lesson on how we should understand politics and respublica.
Pattern of Adenoviral Conjunctivitis Reported to Tertiary Care Hospitals During Epidemic in Pakistan
Authors: Matloob Rana Afia , Yousafzai Erum , Akhter Waseem , Bano Saira 
Published: April 2024

Purpose: To determine clinical pattern of “adenoviral conjunctivitis” during its epidemic in Pakistan.
Patients and Methods: 370 patients (550eyes) diagnosed with “adenoviral conjunctivitis” were included in this descriptive study. Diagnosis was made by the combination of characteristic clinical features and a positive conjunctival swab PCR for “adenovirus”. Clinical pattern of “adenoviral conjunctivitis” was determined by documenting various patient characteristics. Data were analyzed using SPSS 22.
Results: Median age of the study participants was 28.50 (1.00 – 67.00) years. 195 (52.70%) were males and 175 (47.30%) were females. 190 (51.35%) patients had unilateral ocular involvement, while 180 (48.65%) patients had bilateral ocular involvement. Median number of family members of patients that were infected simultaneously was 1 (0-5). Frequency of patients with “adenoviral conjunctivitis” who had concomitant corneal involvement was 30 (8.1%)
Conclusion: Epidemic of “adenoviral conjunctivitis” in Pakistan, fortunately, exhibits a milder and benign clinical pattern with higher prevalence in males and mostly involving single eye. In addition, only 8.1% patients have concomitant corneal involvement.
Comparison between Myoinositol and Metformin on Biochemical Profile in Women with Polycystic Ovarian Syndrome
Authors: Nisa Zaib Un , Murtaza Faiza , Kiran Sidra , Sabir Sehrish , Anam Sidra , Khurshid Irem 
Published: April 2024

Background: The most common endocrine disorder in women during their reproductive years is polycystic ovary syndrome. Metformin is one of the effective oral insulin sensitizing agent it is also considered first line agent in the treatment of this syndrome. Myoinositol is a new emerging agent in the treatment of polycystic, evidences are showing myoinositol is the good addition for the treatment of polycystic syndrome.
Objectives: To compare the outcome of myoinositol and metformin on biochemical profile in women with polycystic ovarian disease.
Methods: This comparative randomized controlled trial was carried out at the Gynecology and Obstetrics Department of Benazir Bhutto Hospital Rawalpindi, from October 2022 to April 2023. The study involved 100 female patients aged 18 to 35 diagnosed with polycystic ovarian syndrome. The participants randomly were assigned to two groups: Group-I received myoinositol (1 gram twice daily) for 24 weeks, and Group-II received metformin (500mg thrice daily) for the same duration. Hormonal parameters, including FSH, LH, LH/FSH ratio, and fasting blood glucose (measured after 8 hours of overnight fasting), were assessed at baseline and after 24 weeks.
Results: The patients mean age was 28.12±4.84 years. The metformin-treated group exhibited mean baseline values of 7.65±2.79, 5.19±1.79, 1.54±0.68, and 90.82±10.72 for LH, FSH, LH/FSH ratio, and fasting blood sugar, respectively. After 24 weeks of treatment, these values decreased to 6.16±2.57, 4.34±1.65, 1.50±0.68, and 85.96±5.72 (p ≤ 0.05). In the myoinositol-treated group, the mean baseline values were 6.37±3.90, 4.66±1.37, 1.51±1.29, and 88.52±11.13 for LH, FSH, LH/FSH ratio, and fasting blood sugar, respectively. After 24 weeks of treatment, these values decreased to 4.54±2.56, 3.71±1.39, 1.37±1.05, and 88.10±4.43 (p ≤ 0.05).
Conclusion: This study concluded that myoinositol demonstrates superior efficacy compared to metformin in enhancing the biochemical profile of individuals with polycystic ovarian syndrome.
Frequency and Clinical Implications of Atrial Fibrillation in Patients with Accessory Pathways
Authors: Hameed Ullah  , Nasir Ali  , Talia Mansoor  , Romana  , Muhammad Idrees Khan  , Zahoor Ahmad Khan  
Published: April 2024

Abstract:
Atrial fibrillation (AF) is a common arrhythmia associated with various cardiac conditions. This study investigates the frequency of AF in patients with accessory pathways, anomalous electrical connections that can lead to supraventricular tachycardia.
Objective:
The primary objectives are to determine the prevalence of AF in patients with accessory pathways, identify associated factors, and assess the impact on clinical outcomes. A comprehensive dataset of 400 patients undergoing supraventricular tachycardia ablation at Hayatabad Medical Complex from 2020 to 2022 was analyzed.
Method:
A retrospective study design was employed, utilizing patient records with documented accessory pathway(s) and complete clinical-electrophysiological data. Demographic information, clinical presentation, electrocardiographic and electrophysiological data, ablation procedures, and clinical outcomes were systematically collected. Analytical approaches included frequency calculation, comparative analysis, regression analysis, and outcome assessment.
Result:
Out of 400 patients, 3.5% presented with AF at the time of accessory pathway ablation. Age was identified as a significant predictor of AF occurrence, with a mean age of 63.2 years in AF cases compared to 55.8 years in non-AF cases. Recurrence of arrhythmias was observed in 57.1% of patients with AF, emphasizing the need for ongoing monitoring and management.
Conclusion:
This study contributes valuable insights into the relatively low prevalence of AF in patients with accessory pathways. While certain factors, including age, may be associated with AF, they do not serve as definitive predictors. Tailored management and adherence to guidelines are crucial for optimizing outcomes in this unique patient population. Future research may explore genetic factors and refine risk stratification models for a deeper understanding of AF in patients with accessory pathways.