bluuebunny/crossref_metadata_2025_split huggingface dataset:
BenthicNet: A global compilation of seafloor images for deep learning applications
Authors: Lowe Scott C. , Misiuk Benjamin , Xu Isaac , Abdulazizov Shakhboz , Baroi Amit R. , Bastos Alex C. , Best Merlin , Ferrini Vicki , Friedman Ariell , Hart Deborah , Hoegh-Guldberg Ove , Ierodiaconou Daniel , Mackin-McLaughlin Julia , Markey Kathryn , Menandro Pedro S. , Monk Jacquomo , Nemani Shreya , O’Brien John , Oh Elizabeth , Reshitnyk Luba Y. , Robert Katleen , Roelfsema Chris M. , Sameoto Jessica A. , Schimel Alexandre C. G. , Thomson Jordan A. , Wilson Brittany R. , Wong Melisa C. , Brown Craig J. , Trappenberg Thomas 
Published: February 2025

Abstract
Advances in underwater imaging enable collection of extensive seafloor image datasets necessary for monitoring important benthic ecosystems. The ability to collect seafloor imagery has outpaced our capacity to analyze it, hindering mobilization of this crucial environmental information. Machine learning approaches provide opportunities to increase the efficiency with which seafloor imagery is analyzed, yet large and consistent datasets to support development of such approaches are scarce. Here we present BenthicNet: a global compilation of seafloor imagery designed to support the training and evaluation of large-scale image recognition models. An initial set of over 11.4 million images was collected and curated to represent a diversity of seafloor environments using a representative subset of 1.3 million images. These are accompanied by 3.1 million annotations translated to the CATAMI scheme, which span 190,000 of the images. A large deep learning model was trained on this compilation and preliminary results suggest it has utility for automating large and small-scale image analysis tasks. The compilation and model are made openly available for reuse.
Tumor characteristics and survival rate of axillary metastatic breast cancer patients: a three decades retrospective cohort study
Authors: Mousavi-kiasary Seyed Mohamad Sadegh , Bayat Mahdis , Abbasvandi Fereshteh , Khoundabi Batoul , Mousavi Fatemeh , Akbari Atieh , Bagherian Maryam , Zandi Afsoon , Honarvar Behnam , Akbari Mohammad Esmaeil 
Published: February 2025

Abstract
Background: Lymph node (LN) involvement, as an important prognostic factor in breast cancer (BC) patients, has a crucial role in their therapeutic approach. Consequently, a great desire is to thoroughly assess the patients based on their axillary LN status. The present study evaluated the characteristics and survival rate of axillary metastatic BC patients in a Tertiary and referral center. Method: The overall survival, disease-free survival, and clinicopathological characteristics of axillary metastatic BC patients referred to the Cancer Research Center in Tehran, Iran, from 1991 to 2022 were assessed retrospectively. We obtained patients’ clinical data from prospectively maintained registries. Result: Among the total 3399 recruited patients, 49.1%, 26.3%,13.1%, and 6.4% were pN0, pN1, pN2 and pN3, respectively. The pN0 group patients showed a significantly lower Hazard Ratio (HR) for DFS and OS compared to others. Moreover, estrogen and progesterone receptors, human epidermal growth factor2, tumor pathology type and tumor grade were prognostic factors of axillary LN status. Accordingly, pN0 patients had a lower recurrence risk than the others (P = 0.01). Conclusion: The axillary lymph node status has been considered as one of the fundamental factors determining the therapeutic strategy and prognosis of BC patients, which has an association with tumor characteristics. Regarding the crucial impact of the LN status on the survival landscape of breast cancer patients, accurate detection of the involved one and close screening follow-up of patients with more metastatic LNs during the surgery have a high value.
Biological control of Schistocerca gregaria and Locusta migratoria migratorioides using Entomopathogenic bacteria
Authors: Muhammad Jihan , Fathy Zeinab , Moussa Saad 
Published: February 2025

Abstract
This study investigated the potential of indigenous entomopathogenic bacterial (EPB) strains from Egypt to control the two most prevalent locust species, Schistocerca gregaria (Forsskål) (Orthoptera: Acrididae), and Locusta migratoria migratorioides (Reiche & Fairmaire) (Orthoptera: Acrididae). To assess the efficacy of the EPB strains, experiments were conducted in the laboratory, semi field, and field. The results showed that Xenorhabdus nematophila (Thomas et Poinar) BA2 (Enterobacterales: Morganellaceae) and Photorhabdus luminescens (Thomas et Poinar) EGAP3 (Enterobacterales: Morganellaceae) were the most effective strains against S. gregaria and L. migratoria migratorioides in laboratory settings. Under semi-field conditions, X. nematophila BA2 recorded nymphal mortality rates of 89.31% and 85.00% against the 2nd and 5th nymph instars of S. gregaria, respectively, and P. luminescens EGAP3 showed nymphal mortality rates of 88.00% and 80.00% against the 2nd and 5th nymph instars of S. gregaria, respectively. In field trials, X. nematophila BA2 exhibited the highest nymphal mortality rate of 88.70% at 7 days after spraying. Overall, the findings of this study suggest that X. nematophila BA2 and P. luminescens EGAP3 are promising candidates for environment-friendly, safe locust pest management. Further research is needed to explore and develop these bacteria for commercial use in agriculture.
Electrophysiologically calibrated optogenetic stimulation of dentate granule cells mitigates dendritic spine loss in denervated organotypic entorhino-hippocampal slice cultures
Authors: Hanauske Tijana , Koretz Carolin Christina , Jungenitz Tassilo , Roeper Jochen , Drakew Alexander , Deller Thomas 
Published: February 2025

Abstract
Organotypic slice cultures (OTCs) are versatile tools for studying long-term structure-function relationships of neurons within a defined network (e.g. hippocampus). We developed a method for repeated experimenter-controlled activation of hippocampal granule cells (GCs) in OTCs within the incubator. After several days of contact-free photonic stimulation, we were able to ameliorate entorhinal denervation-induced structural damage in GCs. To achieve this outcome, we had to calibrate the intensity and duration of optogenetic (light) pulses using whole-cell electrophysiological recordings and multi-cell calcium imaging. Our findings showed that ChR2-expressing cells generated action potentials (APs) or calcium transients in response to illumination but were otherwise functionally indistinguishable from non-transduced GCs within the same neural circuit. However, the threshold for AP firing in single GCs varied based on the stimulus light intensity and the expression levels of ChR2. This information allowed us to calibrate light intensity for chronic stimulations. Denervated GCs exhibited significant spine loss four days post-denervation, but this detrimental effect was mitigated when AP firing was induced at a physiological GC bursting rate. Phototoxic damage caused by chronic light exposure was significantly reduced if illuminated with longer wavelength and by adding antioxidants to the culture medium. Our study presents a versatile approach for concurrent non-invasive manipulation and observation of neural circuit activity and remodeling in vitro.
Global trends and epidemiological impact of metabolic risk factors on atrial fibrillation and atrial flutter from 1990 to 2021
Authors: Liang Junqing , Shen Jun , Guo Yankai , Rejiepu Manzeremu , Ling Xiuwen , Wang Xiaoyan , Jian Yi , Zhang Xing , Shao Shijie , Tang Baopeng , Zhang Ling 
Published: February 2025

Abstract
Atrial fibrillation (AF) and atrial flutter (AFL) are cardiac arrhythmias associated with high morbidity and mortality. This cross-sectional observational study assesses the epidemiological burden of AF/AFL concerning metabolic risk factors using the Global Burden of Disease (GBD) 2021 database. Age-standardized disability-adjusted life years rate (ASDR), mortality, and estimated annual percentage change were calculated. The Bayesian Age-Period-Cohort model was utilized to predict future trends in ASDR and age-standardized mortality rate (ASMR) for AF/AFL 2030. Between 1990 and 2021, ASDR rose from 34.22 to 34.94, whereas ASMR increased from 1.46 to 1.50 per 100,000 people. High/high–middle Socio-Demographic Index (SDI) regions showed decreasing trends in ASDR and ASMR, whereas low and middle SDI regions showed increasing trends. In 2021, the highest ASDR and ASMR were recorded in Australasia, North America, and Western Europe, with significant country-level variability. Projections indicate a declining trend in ASMR and stable ASDR through 2030. The global rise in AF/AFL attributable to metabolic risk factors necessitates comprehensive and region-specific public health strategies. Further research is warranted to develop and implement effective measures to mitigate these conditions and improve cardiovascular health outcomes worldwide.
A multipath error cancellation method based on antenna jitter
Authors: Liu Jiyang , Wang Feixue , Tang Xiaomei , Wang Sixin , Yuan Muzi 
Published: February 2025

Abstract
Global Navigation Satellite System signals are often affected by multipath errors, which impact the accuracy of positioning measurements. Traditional methods frequently fail to effectively mitigate multipath errors across different environments, primarily due to their inherent sensitivity to varying conditions. Here, we propose a multipath error cancellation method that utilizes antenna jitter, which mitigates multipath errors by rapidly changing the relative phases of direct and multipath signals without requiring changes to the receiver structure. The model that combines theoretical analysis with experimental verification is conducted to identify the minimum jitter amplitude required for effective error reduction in straight-line jitter scenarios. Moreover, extensive satellite data collection and verification were performed in Changsha, China, from December 2023 to August 2024. The results indicate that the proposed method enhances robustness and applicability across various environments compared to traditional approaches. Notably, it enables a vehicle-mounted antenna, priced at just a few dollars, to achieve positioning accuracy comparable to that of high-precision antennas costing thousands of dollars, making advanced positioning technology more accessible.
Haploinsufficient phenotypes promote selection of PTEN and ARID1A-deficient clones in human colon
Authors: Skoufou-Papoutsaki Nefeli , Adler Sam , Mehmed Shenay , Tume Claire , Olpe Cora , Morrissey Edward , Kemp Richard , Girard Anne-Claire , Moutin Elisa B , Chilamakuri Chandra Sekhar Reddy , Miller Jodi L , Lindskog Cecilia , Werle Fabian , Marks Kate , Perrone Francesca , Zilbauer Matthias , Tourigny David S , Winton Douglas J 
Published: February 2025

Abstract
Cancer driver mutations are defined by their high prevalence in cancers and presumed rarity in normal tissues. However, recent studies show that positive selection in normal epithelia can increase the prevalence of some cancer drivers. To determine their true cancer-driving potential, it is essential to evaluate how frequent these mutations are in normal tissues and what are their phenotypes. Here, we explore the bioavailability of somatic variants by quantifying age-related mutational burdens in normal human colonic epithelium using immunodetection in FFPE samples (N = 181 patients). Positive selection of variants of tumour suppressor genes PTEN and ARID1A associates with monoallelic gene loss as confirmed by CRISPR/Cas9 mutagenesis and changes in their downstream effectors. Comparison of the mutational burden in normal tissue and colorectal cancers allows quantification of cancer driver potency based on relative representation. Additionally, immune exclusion, a cancer hallmark feature, is observed within ARID1A-deficient clones in histologically normal tissue. The behaviour resulting from haploinsufficiency of PTEN and ARID1A demonstrates how somatic mosaicism of tumour suppressors arises and can predispose to cancer initiation.
Disruption of fibrillar assemblies of l-phenylalanine using polyphenol-passivated nanocarbon as a potential therapeutic strategy against phenylketonuria
Authors: Chatterjee Subir , Kumar Krishan , Kumar Piyush , Thakur Ashwani K. , Misra Santosh K. 
Published: February 2025

Polyphenol passivated nanocarbon system with potential to disrupt and inhibit the fibrillar assemblies of aromatic amino acid l-phenylalanine at pathological concentrations.
BH3·SMe2 addition enables molar mass control via chain stabilization in phosphine–borane dehydropolymerization
Authors: Wiebe Matthew A. , Watson Jade E. T. , Killeen Charles , McIndoe J. Scott , Staubitz Anne , Manners Ian 
Published: February 2025

BH3·SMe2 enables control over the molecular weight of [PhPH–BH2]n, resulting in high molecular weight, low dispersity polyphosphinoboranes. A new mechanism is proposed, highlighting the role of Lewis acid–base equilibria in regulating chain growth.
Drop splitting on hydrophobic wedge-shaped tips after central impact: effect of sharpness and wetting properties
Authors: Zhou Xiaoteng , Diaz Diego , Ni Zhongyuan , Shumaly Sajjad , Liu Jie , Kappl Michael , Butt Hans-Jürgen 
Published: February 2025

Does a knife-like wedge-shaped tips always split a centrally impacting water drop? Here, we combine experiments and volume of fluid (VOF) simulations to investigate this process. The answer might surprise you—find out in this manuscript.
Accentuation Affects the Planning Scope and Focus–Accentuation Consistency Modulates Sentence Production: Evidence From Eye Movements
Authors: Zhang Zhenghua , Zhang Qingfang 
Published: February 2025

Purpose:
Previous studies have shown that the planning scope of sentence production is flexible and influenced by a range of linguistic and extralinguistic factors. However, one important aspect that remains underexplored is the role of prosody, a key component of language, in shaping the planning scope. While it has been established that both conceptual and grammatical information influence sentence production and conceptual information is closely linked with prosodic cues, it remains unclear whether and how prosody, particularly accentuation, affects the planning process. Additionally, there is limited understanding of how conceptual (focus) and prosodic (accentuation) information interact to influence sentence production. Therefore, this study aims to investigate whether prosody (specifically, sentence accentuation) influences the planning scope and how the interaction between conceptual focus and prosodic accentuation jointly shapes sentence production.

Method:
Question–answer pairs were used to create focus, and a red dot was added in scenarios as a cue for accentuation. Participants were asked to complete a picture description task and accent the entity with a red dot. We manipulated the accentuation position (initial vs. medial) and focus–accentuation consistency (consistent vs. inconsistent).

Results:
Speech latencies with initial accentuation were shorter than with medial accentuation. Eye-tracking data indicated that speakers preferred to fixate on accented pictures before articulation in initial accentuation, whereas in medial accentuation, speakers first preferred to fixate on deaccented pictures before shifting to accented ones. Both speech and first fixation latencies on accented pictures were shorter in the consistent condition. In the initial accentuation, accented−deaccented advantage scores were higher in the consistent condition from scenario onset to speech onset, while in the medial accentuation, this difference emerged after 220 ms. In addition, a focus inconsistent with the accentuation position slightly increases the acoustic prominence of deaccented information.

Conclusions:
Accentuation positions affect planning scope, with a larger scope for medial accentuation. Additionally, the consistency between focus and accentuation influences sentence production, broadly affecting the processing of accented information and impacting external acoustic prominence. This influence on accented information processing occurs during the conceptualization and linguistic encoding phases, with processing starting more quickly and taking priority when focus and accentuation are consistent. This study provides a more comprehensive understanding of how various linguistic components interact to shape sentence production.

Supplemental Material:

https://doi.org/10.23641/asha.28306436
Exploring the capability of the HH 80-81 protostellar jet to accelerate relativistic particles
Authors: Méndez-Gallego J. , López-Coto R. , de Oña Wilhelmi E. , Fedriani R. , Otero-Santos J. , Cantürk Y. 
Published: February 2025

Context. Protostellar jets driven by massive protostars are collimated outflows producing high-speed shocks through dense interstellar medium. Fast shocks can accelerate particles up to relativistic energies via diffusive shock acceleration, producing non-thermal emission that can generate γ-ray photons. HH 80-81 is one of the most powerful collimated protostellar jets in our Galaxy, with non-thermal emission detected in radio, X-ray, and γ-ray bands. Characterizing the γ-ray emission that originates in the accelerated particles of the region is crucial for demonstrating the capability of protostars to accelerate cosmic rays.
Aims. Our goal is to determine the particle distribution that is producing the γ-ray spectrum of HH 80-81 in order to ascertain the leptonic or hadronic origin of the γ-ray emission. We aim to associate the high-energy emission in the region with the HH 80-81 system, characterize its spectrum, and elaborate emission models based on what we expect from the diffusive shock acceleration.
Methods. We use the 15 yr database provided by the Fermi-LAT satellite to study the high-energy emission of the jet, spanning from 300 MeV to 100 GeV. In addition, we perform a source association based on positional arguments. Then, we employ the naima and Gamera softwares to analyze the possible mechanisms that are producing γ-rays, considering the ambient conditions. We perform a radiative fitting and study the nature of the particles behind the γ-ray emission.
Results. By analyzing all the candidates to produce the γ-ray emission that we detect, we conclude that HH 80-81 is the most probable candidate to explain the γ-ray emission in the region. The detected spectrum can be explained by both hadronic and leptonic particle components.
Die Beziehung zwischen Symptomschwere und dem Einfluss traumatischer
Kindheitserfahrungen bei Patienten mit Onlinesexsucht und Patienten mit
Computerspielsucht
Authors: Wölfling Klaus , Beutel Manfred E. , Dominick Nanne , Zumbansen Greta , Müller Kai W. 
Published: February 2025

ZusammenfassungDie Onlinesexsucht gewinnt in der digitalen Welt zunehmend an Relevanz, da
einfacher Zugang zu sexuellen Inhalten die Befriedigung sexueller
Bedürfnisse jederzeit ermöglicht und dies oft mit sozialer Isolation und
realweltlichen Intimitätsproblemen einhergeht. Ziel der vorliegenden Studie
ist es, den Zusammenhang zwischen traumatischen Kindheitserfahrungen und der
Schwere der Symptome bei Patienten mit Onlinesexsucht im Vergleich zu
Patienten mit Computerspielsucht zu untersuchen, wobei angenommen wird, dass
spezifische Traumata die Symptomschwere bei beiden Störungen
beeinflussen.Die Studie untersuchte Daten von 260 männlichen Patienten, die sich wegen
einer vermuteten Onlinesexsucht oder einer Computerspielsucht in einer
Spezialambulanz für Verhaltenssüchte vorstellten. Nachdem eine klinische
Diagnostik die Störungen identifizierte, wurde mithilfe von Fragebögen
Symptomschwere und traumatische Kindheitserfahrungen erfasst. Nachfolgend
wurden die Beziehungen zwischen traumatischen Erlebnissen und der Schwere
der jeweiligen Suchtstörung analysiert.Die Ergebnisse zeigen, dass zwischen den Patientengruppen keine signifikanten
Unterschiede in der Symptomschwere der spezifischen Abhängigkeit bestanden.
Traumatische Kindheitserfahrungen, wie emotionale Vernachlässigung,
korrelieren stärker mit der Computerspielsucht, während in der Kindheit
erlebter sexueller Missbrauch signifikant häufiger bei Betroffenen mit
Onlinesexsucht auftritt und nur in dieser Gruppe die Symptomschwere der
spezifischen Abhängigkeit vorhersagen kann.Sowohl die Entwicklung der Onlinesexsucht als auch der Computerspielsucht
kann durch spezifische traumatische Kindheitserfahrungen determiniert sein,
wobei sexueller Missbrauch signifikant mit der Symptomschwere der
Onlinesexsucht korreliert und emotionale Vernachlässigung stärker mit der
Computerspielsucht in Verbindung steht. Die Ergebnisse legen nahe, dass
unterschiedliche Verhaltenssüchte unterschiedliche Behandlungsansätze
erfordern, um gezielt auf die individuellen Erfahrungen und Bedürfnisse der
Betroffenen einzugehen.
Post COVID-19 Condition Patients with Dyspnea Show Diaphragm
Dysfunction in Sonographic Imaging – a Prospective Observational
Study
Authors: Reißhauer Anett , Lerchbaumer Markus Herbert , Drebinger Daniel Andreas , Liebl Max Emanuel , Münch Sebastian , Fischer Thomas 
Published: February 2025

AbstractAround 6.2% of patients report symptoms as
fatigue, muscle pain and dyspnea more than three months after SARS-CoV-2
infection, defined as post COVID-19 condition (PCC). Non-hospitalized
patients with PCC often show normal pulmonary functioning tests and imaging
but suffer from respiratory symptoms. On clinical examination, PCC with
dyspnea show signs of diaphragmatic dysfunction. The study aimed to
objectively visualize and quantify the diaphragmatic function using
sonographic parameters in PCC patients with and without dyspnea.Adult PCC patients were prospectively
assessed for dysfunctional breathing and diaphragmatic stiffness using
sonographic imaging. Multiparametric sonography evaluated diaphragm
thickness, mobility, stiffness and elasticity in different breathing cycles
using B-mode imaging, M-mode and quantitative shear wave elastography. PCC
patients were stratified into two groups with and without dyspnea.Fifty-four post-COVID patients were assessed, of
whom n=24 (44.4%) reported dyspnea and presented dysfunctional breathing,
while 30 PCC without dyspnea served as control. PCC with dyspnea compared to
PCC without dyspnea showed a less deep first breath (5.8 mm vs. 6.5 mm,
p=0.044), reduced diaphragm thickness on inspiration (3.4 mm vs. 3.9 mm,
p=0.030), as well as less increase of diaphragmatic elasticity (108% vs.
146%; p=0.027) and diaphragmatic stiffness (40% vs. 53%; p=0.022) during
inspiration.Diaphragm dysfunction as a possible origin of
dyspnea in PCC can be assessed and objectively quantified using
multiparametric sonography and may help evaluate therapeutic interventions
that are otherwise overlooked.