bluuebunny/crossref_metadata_2025_split huggingface dataset:
The VertiGO! Trial protocol: A prospective, single-center, patient-blinded study to evaluate efficacy and safety of prolonged daily stimulation with a multichannel vestibulocochlear implant prototype in bilateral vestibulopathy patients
Authors: Vermorken Bernd L. , Volpe Benjamin , van Boxel Stan C. J. , Stultiens Joost J. A. , van Hoof Marc , Marcellis Rik , Loos Elke , van Soest Alexander , McCrum Chris , Meijer Kenneth , Guinand Nils , Pérez Fornos Angélica , van Rompaey Vincent , Devocht Elke , van de Berg Raymond 
Published: March 2024

Background
A combined vestibular (VI) and cochlear implant (CI) device, also known as the vestibulocochlear implant (VCI), was previously developed to restore both vestibular and auditory function. A new refined prototype is currently being investigated. This prototype allows for concurrent multichannel vestibular and cochlear stimulation. Although recent studies showed that VCI stimulation enables compensatory eye, body and neck movements, the constraints in these acute study designs prevent them from creating more general statements over time. Moreover, the clinical relevance of potential VI and CI interactions is not yet studied. The VertiGO! Trial aims to investigate the safety and efficacy of prolonged daily motion modulated stimulation with a multichannel VCI prototype.

Methods
A single-center clinical trial will be carried out to evaluate prolonged VCI stimulation, assess general safety and explore interactions between the CI and VI. A single-blind randomized controlled crossover design will be implemented to evaluate the efficacy of three types of stimulation. Furthermore, this study will provide a proof-of-concept for a VI rehabilitation program. A total of minimum eight, with a maximum of 13, participants suffering from bilateral vestibulopathy and severe sensorineural hearing loss in the ear to implant will be included and followed over a five-year period. Efficacy will be evaluated by collecting functional (i.e. image stabilization) and more fundamental (i.e. vestibulo-ocular reflexes, self-motion perception) outcomes. Hearing performance with a VCI and patient-reported outcomes will be included as well.

Discussion
The proposed schedule of fitting, stimulation and outcome testing allows for a comprehensive evaluation of the feasibility and long-term safety of a multichannel VCI prototype. This design will give insights into vestibular and hearing performance during VCI stimulation. Results will also provide insights into the expected daily benefit of prolonged VCI stimulation, paving the way for cost-effectiveness analyses and a more comprehensive clinical implementation of vestibulocochlear stimulation in the future.

Trial registration
ClinicalTrials.gov: NCT04918745. Registered 28 April 2021.
Metabolomic response to acute resistance exercise in healthy older adults by 1H-NMR
Authors: Moosavi Darya , Vuckovic Ivan , Kunz Hawley E. , Lanza Ian R. 
Published: March 2024

Background
The favorable health-promoting adaptations to exercise result from cumulative responses to individual bouts of physical activity. Older adults often exhibit anabolic resistance; a phenomenon whereby the anabolic responses to exercise and nutrition are attenuated in skeletal muscle. The mechanisms contributing to age-related anabolic resistance are emerging, but our understanding of how chronological age influences responsiveness to exercise is incomplete. The objective was to determine the effects of healthy aging on peripheral blood metabolomic response to a single bout of resistance exercise and whether any metabolites in circulation are predictive of anabolic response in skeletal muscle.

Methods
Thirty young (20–35 years) and 49 older (65–85 years) men and women were studied in a cross-sectional manner. Participants completed a single bout of resistance exercise consisting of eight sets of 10 repetitions of unilateral knee extension at 70% of one-repetition maximum. Blood samples were collected before exercise, immediately post exercise, and 30-, 90-, and 180-minutes into recovery. Proton nuclear magnetic resonance spectroscopy was used to profile circulating metabolites at all timepoints. Serial muscle biopsies were collected for measuring muscle protein synthesis rates.

Results
Our analysis revealed that one bout of resistance exercise elicits significant changes in 26 of 33 measured plasma metabolites, reflecting alterations in several biological processes. Furthermore, 12 metabolites demonstrated significant interactions between exercise and age, including organic acids, amino acids, ketones, and keto-acids, which exhibited distinct responses to exercise in young and older adults. Pre-exercise histidine and sarcosine were negatively associated with muscle protein synthesis, as was the pre/post-exercise fold change in plasma histidine.

Conclusions
This study demonstrates that while many exercise-responsive metabolites change similarly in young and older adults, several demonstrate age-dependent changes even in the absence of evidence of sarcopenia or frailty.

Trial registration
Clinical trial registry: ClinicalTrials.gov NCT03350906.
How negative self-views may interfere with building positive relationships: An experimental analogue of identity dysfunction in borderline personality disorder
Authors: van Schie Charlotte C. , Whiting Laura , Grenyer Brin F. S. 
Published: March 2024

Introduction
A disturbed, negative sense of self is associated with various interpersonal difficulties and is characteristic of disorders such as borderline personality disorder (BPD). Negative self-views may affect an individuals’ ability to build positive relationships, including a therapeutic relationship. However, it is not yet well understood how identity disturbances give rise to interpersonal difficulties. Using an experimental analogue design, we tested whether identity disturbances are associated with interpersonal difficulties.

Methods
Participants were university students (N = 43, age M = 20.51 (SD = 3.08), women N = 32 (74.4%)) who reported moderate to high levels of BPD features, with 34.9% reporting significant BPD features as measured by the Borderline scale of the Personality Assessment Inventory (PAI-BOR). In a within-subject experimental paradigm using a Social Feedback Task, participants received negative, intermediate, and positive evaluations, supposedly from a panel. Using multilevel models, we tested whether negative self-views were associated with how much the participants liked, trusted, and felt close to each of the three panel members who provided either predominantly negative, intermediate, or positive feedback.

Results
People with more negative self-views reported lower mood in response to positive feedback. In addition, where people with more positive self-views felt better when receiving feedback that was congruent with their self-views, people with more negative self-views did not report a better mood. Importantly, people with negative self-views felt lower desire to affiliate with the member who provided predominantly positive feedback. Affiliation was not affected when feedback was given by the negative member and intermediate member to those with negative self-views.

Conclusions
The findings validated that those with more negative self-views anticipated and expected more negative responses from others. Negative self-views, as relevant for BPD, may explain how people relate differently to those giving different types of feedback. Pervasive negative self-views may interfere with building new relationships including the therapeutic alliance. It may be helpful for clinicians to be aware of the potential challenges around creating a supportive therapeutic relationship for patients with negative self-views. Overly positive affirmations made by clinicians may inadvertently lower the patient’s mood and may impede alliance formation.
A high-selectivity ceramic bandpass filter with controllable transmission zeros
Authors: Fang Yingxuan , Yu Mengxia , Zhang Xiaochuan , Zhang Rou , Ma Jing 
Published: March 2024

Abstract
This paper proposes a microstrip filter with controllable transmission zeros based on the λ/4 stepped impedance resonator. This filter utilizes hybrid electric-magnetic coupling to generate transmission zeros, which can improve selectivity and stop-band performance. A fifth-order filter is designed and manufactured on a ceramic substrate with a center frequency of 26 GHz, bandwidth of 2 GHz and the signal suppression level is better than 42.51 dB from 10 to 22.8 GHz and 48.23 dB from 29.1 to 40 GHz. Furthermore, the proposed filter has a compact size of 2.074 × 1.071 mm (0.566λ

g
× 0.292λ

g
).
Exploring the Social Context of Self-directed Learning in the Contemporary Workplace
Authors: Hrabalová Veronika , Urban Kamila 
Published: March 2024

Abstract
The evolving landscape of workforce learning underscores the increasing importance of self-directed learning (SDL) within business organizations. SDL shifts the learning responsibility to learners themselves, requiring self-control, self-management, and autonomous motivation. Despite its numerous benefits for both business organizations and workers, it is challenged by the varying degrees of workers’ individual self-direction. This literature review aims to articulate the significance of social context – the support from leaders and peers – in facilitating workers’ SDL. It highlights leader autonomy support as the key factor of fostering workers’ autonomous motivation in SDL. Moreover, it examines the role of learner-peer interactions, including help, feedback, and information seeking, as specific aspects of peer support. These interactions further facilitate positive attitudes towards SDL and advance problem-solving, potentially leading to collaborative learning. The literature review is concluded by outlining possible future research directions.
Periodic analysis of scenic spot passenger flow based on combination neural network prediction model
Authors: Yin Fang 
Published: March 2024

Abstract
To prevent in a short time the rapid increase of tourists and corresponding traffic restriction measures’ lack in scenic areas, this study established a prediction model based on an improved convolutional neural network (CNN) and long- and short-term memory (LSTM) combined neural network. The study used this to predict the inflow and outflow of tourists in scenic areas. The model uses a residual unit, batch normalization, and principal component analysis to improve the CNN. The experimental results show that the model works best when batches’ quantity is 10, neurons’ quantity in the LSTM layer is 50, and the number of iterations is 50 on a workday; on non-working days, it is best to choose 10, 100, or 50. Using root mean square error (RMSE), normalized root mean square error (NRMSE), mean absolute percentage error (MAPE), and mean absolute error (MAE) as evaluation indicators, the inflow and outflow RMSEs of this study model are 82.51 and 89.80, MAEs are 26.92 and 30.91, NRMSEs are 3.99 and 3.94, and MAPEs are 1.55 and 1.53. Among the various models, this research model possesses the best prediction function. This provides a more accurate prediction method for the prediction of visitors’ flow rate in scenic spots. Meanwhile, the research model is also conducive to making corresponding flow-limiting measures to protect the ecology of the scenic area.
Medulloblastoma in a child with osteoma cutis – a rare association due to loss of GNAS expression
Authors: Suntharesan Jananie , Lyulcheva-Bennett Ekaterina , Hart Rachel , Pizer Barry , Hayden James , Ramakrishnan Renuka 
Published: March 2024

Abstract

Objectives
Inactivating GNAS mutations result in varied phenotypes depending on parental origin. Maternally inherited mutations typically lead to hormone resistance and Albright's hereditary osteodystrophy (AHO), characterised by short stature, round facies, brachydactyly and subcutaneous ossifications. Paternal inheritance presents with features of AHO or ectopic ossification without hormone resistance. This report describes the case of a child with osteoma cutis and medulloblastoma. The objective of this report is to highlight the emerging association between inactivating germline GNAS mutations and medulloblastoma, aiming to shed light on its implications for tumor biology and promote future development of targeted surveillance strategies to improve outcomes in paediatric patients with these mutations.

Case presentation
A 12-month-old boy presented with multiple plaque-like skin lesions. Biopsy confirmed osteoma cutis, prompting genetic testing which confirmed a heterozygous inactivating GNAS mutation. At 2.5 years of age, he developed neurological symptoms and was diagnosed with a desmoplastic nodular medulloblastoma, SHH molecular group, confirmed by MRI and histology. Further analysis indicated a biallelic loss of GNAS in the tumor.

Conclusions
This case provides important insights into the role of GNAS as a tumor suppressor and the emerging association between inactivating GNAS variants and the development of medulloblastoma. The case underscores the importance of careful neurological assessment and ongoing vigilance in children with known inactivating GNAS variants or associated phenotypes. Further work to establish genotype–phenotype correlations is needed to inform optimal management of these patients.
Tackling access and payer barriers for growth hormone therapy in Saudi Arabia: a consensus statement for the Saudi Working Group for Pediatric Endocrinology
Authors: Attia Najya , Moussa Khairya , Altwaim Abdulaziz , Al-Agha Abdulmoein Eid , Amir Ashraf A. , Almuhareb Aseel 
Published: March 2024

Abstract
Prompt diagnosis and early treatment are key goals to optimize the outcomes of children with growth hormone deficiency (GHD) and attain the genetically expected adult height. Nonetheless, several barriers can hinder prompt diagnosis and treatment of GHD, including payer-related issues. In Saudi Arabia, moderate-to-severe short stature was reported in 13.1 and 11.7 % of healthy boys and girls, respectively. Several access and payer barriers can face pediatric endocrinologists during the diagnosis and treatment of GHD in Saudi Arabia. Insurance coverage policies can restrict access to diagnostic tests for GHD and recombinant human growth hormone (rhGH) due to their high costs and lack of gold-standard criteria. Some insurance policies may limit the duration of treatment with rhGH or the amount of medication covered per month. This consensus article gathered the insights of pediatric endocrinologists from Saudi Arabia to reflect the access and payer barriers to the diagnostic tests and treatment options of children with short stature. We also discussed the current payer-related challenges endocrinologists face during the investigations of children with short stature. The consensus identified potential strategies to overcome these challenges and optimize patient management.
Crystal structure of (E)-N′-(4-((E)-3-(dimethylamino)acryloyl)-3-hydroxyphenyl)-N, N-dimethylformimidamide, C14H19N3O2
Authors: Li Wei-Zhong , Xu Lian-Hua , Liang Chun-Bo , Wang Hua-Bin 
Published: March 2024

Abstract
C14H19N3O2, monoclinic, P21/c (no. 14), a = 8.62239(12) Å, b = 15.3515(3) Å, c = 10.86408(16) Å, β = 99.5170(14)°, V = 1418.25(4) Å3, Z = 4, Rgt
(F) = 0.0452, wRref
(F
2) = 0.1354, T = 295.52(10) K.
Synthesis and crystal structure of 4-(4-cyclopropylnaphthalen-1-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione, C15H13N3S
Authors: Hui-lei Zeng , Ying He , Ding-Wa Zhang , Xiu-Guang Yi , Zhi-Qiang Yi 
Published: March 2024

Abstract
C15H13N3S, monoclinic, P21/c (no. 14), a = 9.9017(6) Å, b = 11.7665(6) Å, c = 11.6065(8) Å, β = 96.262(6)°, V = 1344.19(14) Å3, Z = 4, R
gt(F) = 0.0443, wR
ref(F
2) = 0.1204, T = 296(2) K.
The crystal structure of (E)-2-chloro-5-((2-(nitromethylene)imidazolidin-1-yl)methyl)pyridine, C10H11ClN4O2
Authors: Chen Zhen , Guo Kang , Sun Yanwen , Liu Chang , Li Sijun 
Published: March 2024

Abstract
C10H11ClN4O2, monoclinic, P21/c (no. 14), a = 12.7802(17) Å, b = 7.6211(12) Å, c = 12.0486(17) Å, β = 95.551(4)°, V = 1168.0(3) Å3, Z = 4, R

gt
(F) = 0.0562, wR

ref
(F
2) = 0.1172, T = 273(2) K.
Biodegradability and mechanical behavior of novel hybrid green composites fabricated with cashew shell particle, sisal fiber and corn starch resin
Authors: Musthafa Abdul Kareem , Arulraj Arockia Julias , Rajamanickam Sathish Kumar , Manoharan Mohanraj , Sattanathan Sivakumar , Jeyakumar P.D.  
Published: March 2024

Abstract
Increased use of synthetic non-biodegradable polymeric matrices for composite manufacturing, poses a serious threat to the environment. This necessitates the development of 100 % biodegradable green composites using natural plant-based fibers and biodegradable natural polymers. This study focuses on the biodegradability and mechanical characteristics of biodegradable green hybrid composites fabricated with particles of agricultural waste cashew shell, sisal fibers, and corn starch resin using hand layup followed by compression molding. Mechanical characteristics such as tensile, flexural, impact strength, shore D hardness, and soil burial biodegradation characteristics were studied experimentally. The microstructures of the fractured surfaces were also analyzed through SEM images. Composite sample fabricated with an optimum cashew shell particle proportion of 10 wt %, three sisal fiber mat layers and corn starch resin has recorded the highest mechanical strengths such as 11.4 MPa, 10.9 MPa and 310.15 J/m in tensile, flexural and impact strengths respectively. Thus, the green hybrid composite made with agricultural waste cashew shell particles, sisal fibers, and corn starch resin is a potential and eco-friendly modern material for light load and short-life applications.
Impact of gamma irradiation on phytochemical composition, and biological activities of Lepidium sativum seeds extract
Authors: Hadj Rabia Samia , Debib Aicha , Eddaikra Atika , Aberkane-Mchebbek Lila , Nouri Ramy , Benmoussa Fatima , Mokhtari Amine , Medjber Sarah , Mansouri Belkacem , Messaoudi Mohammed 
Published: March 2024

Abstract
The main objective of this research is to assess how gamma radiation influences the chemical composition and activities such as antioxidant, antimicrobial and anticancer activities of Lepidium sativum (L. sativum) seeds. Methanolic extracts were obtained through a 24 h maceration process from L. sativum seeds exposed to various doses of gamma irradiation. Phytochemical screening involved precipitation and staining reactions, with the antioxidant potential assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Antimicrobial activity was evaluated through a diffusion test on agar medium, while the cytotoxic potential on the lung cancer line “A-549 cells” was examined using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Qualitative analysis of the extracts identified preserved bioactive constituents after irradiation. Additionally, quantitative analysis indicated a significant rise in the total content of polyphenols and flavonoids under radiation, accompanied by an enhanced reducing power compared to the control. The antimicrobial and cytotoxic capabilities also improved, evident in increased growth inhibition zones for certain microbial strains and reduced viability rates of A549 cells. These results show promise and warrant further investigation into the potential of gamma radiation to enhance additional biological effects of plants.
Are Individual Care Investments Affected by Past Accident Experiences?
Authors: Guerra Alice , Parisi Francesco 
Published: March 2024

Abstract
In this paper, we analyze the impact of past accident experiences on individual care choices. By relying on standard economic theory and evidence of behavioral economics and psychology, we posit that individuals’ care investments should be affected by their past accidents as injurers or victims (accident-history effect hypothesis), or by their prior exposure to accident risks in the opposite role (role-reversal effect hypothesis). We test these two hypotheses using experimental data. We find that individuals’ accident history has no statistically significant effect on their care investments, but that care decisions vary with changes in the parties’ roles. Specifically, injurers with prior experience as victims invest statistically more in care than injurers without prior victim experience. By contrast, care investments are not sensitive to victims’ prior experience as injurers. Our research can be regarded as a preliminary study toward the understanding of the role of past accident experiences on individuals’ care behavior, and calls for both replication efforts and reconsideration of traditional economic models of torts.
Cone-Opponent Ganglion Cells in the Primate Fovea Tuned to Non-Cardinal Color Directions
Authors: Godat Tyler , Kohout Kendall , Parkins Keith , Yang Qiang , McGregor Juliette E. , Merigan William H. , Williams David R. , Patterson Sara S. 
Published: March 2024

A long-standing question in vision science is how the three cone photoreceptor types – long (L), medium (M) and short (S) wavelength sensitive – combine to generate our perception of color. Hue perception can be described along two opponent axes: red-green and blue-yellow. Psychophysical measurements of color appearance indicate that the cone inputs to the red-green and blue-yellow opponent axes are M vs. L+S and L vs. M+S, respectively. However, the “cardinal directions of color space” revealed by psychophysical measurements of color detection thresholds following adaptation are L vs. M and S vs. L+M. These cardinal directions match the most common cone-opponent retinal ganglion cells (RGCs) in the primate retina. Accordingly, the cone opponency necessary for color appearance is thought to be established in cortex. However, small populations with the appropriate M vs. L+S and L vs. M+S cone-opponency have been reported in large surveys of cone inputs to primate RGCs and their projections to the lateral geniculate nucleus (LGN), yet their existence continues to be debated. Resolving this long-standing open question is necessary because a complete account of the cone-opponency in the retinal output is critical for efforts to understand how downstream neural circuits process color. Here, we performed adaptive optics calcium imaging to longitudinally, noninvasively measure foveal RGC light responses in the living macaque (Macaca fascicularis) eye. We confirm the presence of L vs. M+S and M vs. L+S neurons with non-cardinal cone-opponency and demonstrate that cone-opponent signals in the retinal output are more diverse than classically thought.Significance StatementRetinal ganglion cells (RGCs) provide the only source of visual information to the brain and thus make up the building blocks for downstream visual processing. Accordingly, a complete account of how RGCs compare the cone photoreceptors is critical for understanding color vision. The cone inputs to the most common primate RGCs establish “cardinal directions” in color space that can explain color detection, but not color appearance. We identified foveal RGCs with non-cardinal cone opponency matching the signed cone inputs to red, green, blue and yellow. While this correlation does not imply causation, it opens new directions for understanding the neural processing of color. Our results indicate that the spectral information in the retinal output is more diverse than classically thought.