bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Mechanics of Elastomeric Sheet Reinforced With Bidirectional Fiber Mesh Subjected to Flexure on Boundaries
Authors: Yao Wenhao , Siddiqui Tahmid Rakin , Kim Chun IL 
Published: March 2024

AbstractWe investigate the concurrent three-dimensional deformations of fiber-reinforced composite sheets subjected to out-of-plane bending moments via a continuum model, where we invoke the neo-Hookean strain energy model for the matrix material of fiber-reinforced composite, and assimilate the strain energy of fiber reinforcements into the matrix material model by accounting for stretching, bending, and twisting kinematics of the fibers through the computations of the first-order and second-order gradient of deformation. Emphasis is placed on deriving the Euler equation and boundary conditions of bending moment within the framework of the variational principle and configuring composite surfaces using differential geometry. Significant attention has been given to illustrating the concurrent three-dimensional deformation of fiber composite, meshwork deformation, and fiber kinematics. The simulation results reveal that for a square fiber composite subjected to the out-of-plane bending moment, the maximum in-plane deformation of matrix material occurs along the diagonal direction of the domain while the center of the domain experiences weak in-plane deformation. Notably, the matrix material performs isotropic/anisotropic properties depending on the domain size/shape. In addition, the simulated unit fiber deformations reasonably validate the overall deformation of the network, underscoring that the deformations of the embedded fiber units govern the overall mechanical performance of the fiber meshwork. More importantly, the continuum model qualitatively provides reasonable predictions on the damage patterns of construction materials by demonstrating the kinematics of matrix material and meshwork deformation.
Supplemental Material: Recycling of Paleo-Tethyan oceanic crust: Geochemical record from Early-Middle Triassic igneous rocks in the East Kunlun Orogen in western China
Authors: Yedan Hu , Ma Li-Tao , et al.  
Published: March 2024

<p>Analytical methods, Figure S1-S6, and Table S1-S7. </p>
Resection Arthroplasty Is a Valuable Strategy for Humeroradial Synostosis – A Case Report
Authors: ALMEIDA Mariana , TAKAGI Takehiko , TORII Akiko , TAKAYAMA Shinichiro 
Published: March 2024

A 15-year-old girl with humeroradial synostosis since birth underwent a resection arthroplasty. A trapezoidal resection osteotomy of approximately 2 cm was performed at the anterior part of the bone flexure. This resulted at 18 months in an elbow arc of motion of 60°–110° and forearm pronation/supination of 40° and 60° without postoperative complications and improved disabilities of the arm, shoulder and hand and Hand 20 scores. Radiographic analysis revealed a humeroradial joint with a maintained pseudarthrosis and hinged motion at the humeroulnar joint. When performed by an experienced surgeon, resection arthroplasty corrects humeroradial synostosis, resulting in improvement in range of motion and quality of life. Level of Evidence: Level V (Therapeutic)
Impaired Relaxation in Induced Pluripotent Stem Cell‐Derived Cardiomyocytes with Pathogenic
TNNI3
Mutation of Pediatric Restrictive Cardiomyopathy
Authors: Wang Renjie , Hasegawa Moyu , Suginobe Hidehiro , Yoshihara Chika , Ishii Yoichiro , Ueyama Atsuko , Ueda Kazutoshi , Hashimoto Kazuhisa , Hirose Masaki , Ishii Ryo , Narita Jun , Watanabe Takuji , Kawamura Takuji , Taira Masaki , Ueno Takayoshi , Miyagawa Shigeru , Ishida Hidekazu 
Published: March 2024

Background

Restrictive cardiomyopathy (RCM) is characterized by impaired diastolic function with preserved ventricular contraction. Several pathogenic variants in sarcomere genes, including
TNNI3
, are reported to cause Ca
2+
hypersensitivity in cardiomyocytes in overexpression models; however, the pathophysiology of induced pluripotent stem cell (iPSC)‐derived cardiomyocytes specific to a patient with RCM remains unknown.

Methods and Results

We established an iPSC line from a pediatric patient with RCM and a heterozygous
TNNI3
missense variant, c.508C>T (p.Arg170Trp; R170W). We conducted genome editing via CRISPR/Cas9 technology to establish an isogenic correction line harboring wild type
TNNI3
as well as a homozygous
TNNI3
‐R170W. iPSCs were then differentiated to cardiomyocytes to compare their cellular physiological, structural, and transcriptomic features. Cardiomyocytes differentiated from heterozygous and homozygous
TNNI3
‐R170W iPSC lines demonstrated impaired diastolic function in cell motion analyses as compared with that in cardiomyocytes derived from isogenic‐corrected iPSCs and 3 independent healthy iPSC lines. The intracellular Ca
2+
oscillation and immunocytochemistry of troponin I were not significantly affected in RCM‐cardiomyocytes with either heterozygous or homozygous
TNNI3
‐R170W. Electron microscopy showed that the myofibril and mitochondrial structures appeared to be unaffected. RNA sequencing revealed that pathways associated with cardiac muscle development and contraction, extracellular matrix‐receptor interaction, and transforming growth factor‐β were altered in RCM‐iPSC‐derived cardiomyocytes.

Conclusions
Patient‐specific iPSC‐derived cardiomyocytes could effectively represent the diastolic dysfunction of RCM. Myofibril structures including troponin I remained unaffected in the monolayer culture system, although gene expression profiles associated with cardiac muscle functions were altered.
Impact of Secondary Amenorrhea on Cardiovascular Disease Risk in Physically Active Women: A Systematic Review and Meta‐Analysis
Authors: Tegg Nicole L. , Myburgh Caitlynd , O'Donnell Emma , Kennedy Megan , Norris Colleen M. 
Published: March 2024

Background
Exercise‐associated secondary amenorrhea results in estrogen deficiency, which may lead to dysfunction in estrogen's normal cardioprotective pathways. Estrogen may be essential in a woman's endothelial adaptations to exercise. The objective of this review was to assess the association between secondary amenorrhea in physically active women and cardiovascular disease (CVD) risk.

Methods and Results
A literature search was performed in January 2023 and updated in August 2023 of the Cumulative Index to Nursing and Allied Health Literature (EBSCOhost), Cochrane Library, Embase (Ovid), MEDLINE (Ovid), SPORTDiscus (EBSCOhost), and Scopus from inception to present with no date or language limitations. Citation chaining was done to screen for additional studies. Eight sources were searched for gray literature. Studies that compared physically active women with amenorrhea to physically active women with eumenorrhea aged 18 to 35 years with evidence of CVD, alterations to cardiovascular physiology, or CVD risks were included. Eighteen observational studies from 3 countries were included. Overall, the quality of evidence was good. A meta‐analysis was performed. Physically active women with secondary amenorrhea had significantly lower estradiol, flow‐mediated dilation, resting heart rate, systolic blood pressure, and diastolic blood pressure and higher total cholesterol, triglycerides, high‐density lipoprotein, and low‐density lipoprotein cholesterol.

Conclusions
Estrogen deficiency resulting from exercise‐associated secondary amenorrhea in physically active women may impact cardiovascular physiology and certain CVD risk factors. The research in this area is observational; therefore, findings should be interpreted cautiously. However, as exercise‐associated secondary amenorrhea is reversible and the primary prevention of CVD is important for public health, it may be important to treat secondary amenorrhea and restore estrogen levels.
Family-Leave Mandates and Female Labor at U.S. Firms: Evidence from a Trade Shock
Authors: Kamal Fariha , Sundaram Asha , Tello-Trillo Cristina J. 
Published: March 2024

Abstract
We examine how the 1993 Family and Medical Leave Act (FMLA) impacts the gender composition at U.S. firms experiencing a negative demand shock. Combining changes in Chinese imports across industries between 2000 and 2003 and a sharp regression discontinuity to identify FMLA status, we find that an increase in import competition decreases the share of female employment, earnings, and promotions at FMLA relative to non-FMLA firms. This effect is driven by women in prime childbearing ages and without college degrees; and is pronounced at firms with all male managers. These results suggest that job-protected leave mandates may exacerbate gender inequalities in response to adverse shocks.
Misspecified Exponential Regressions: Estimation, Interpretation, and Average Marginal Effects
Authors: Silva J.M.C. Santos , Winkelmann Rainer 
Published: March 2024

Abstract
Exponential regressions are frequently used when outcomes are non-negative. They are attractive because they are easy to interpret and to estimate, using pseudo maximum likelihood (PML). However, the validity of these methods depends on the correct specification of the conditional expectation, and little is known regarding their properties when the conditional expectation is misspecified. We show that PML estimators of misspecified exponential models provide optimal approximations to the conditional expectation, in a weighted mean squared error sense, and we give conditions under which their Poisson PML estimator identifies average marginal effects.
A chronological catalog of the New World species of Scolopendra L., 1758 (Chilopoda: Scolopendromorpha: Scolopendridae)
Authors: SHELLEY ROWLAND M. 
Published: March 2024

Since 1758, 140 names have been erected for, transferred into, or assigned to species of Scolopendra occurring in the New World. One hundred sixteen are from definite, though sometimes vague, type localities; 18 are for nominal species without type localities; three lack standing in nomenclature and are invalid; and three are nomina nuda. To facilitate future studies and determining synonymies, these names are cataloged in chronological order in four listings plus a summary roster of senior names and junior subjective synonyms. Additional rosters cite primary homonyms needing rectification and species needing neotypes — ones with revisitable type localities, ones with unknown or overly generalized type localities that cannot be rechecked, and ones whose type specimens may still exist. The Mexican species, S. robusta Kraepelin, 1903, inadvertently reduced to subspecific status under S. gigantea L., 1758, in a popularized booklet, is returned to full specific status and deleted from Colombia, and S. punctiscuta Wood, 1861, is placed in synonymy under S. heros Girard, 1853, which is deleted from India. Scolopendra sumichrasti Saussure, 1860, & S. olmeca Humbert & Saussure, 1969, are possible synonyms of S. pomacea C. L. Koch, 1847. The synonymy of S. viridilimbata Daday, 1891, under S. polymorpha Wood, 1861, is accepted, and the following established synonymies are confirmed: under S. alternans Leach, 1815 — S. sagraea Gervais, 1837, S. cubensis Saussure, 1860, S. complanata, S. multispinata, & S. grayi, all by Newport, 1844, and S. torquata & S. testacea, both by Wood, 1861; under S. subspinipes Leach, 1815 — S. sexspinosa Newport, 1844, and S. placea & S. lutea, both by Newport, 1845; under S. morsitans L., 1758, S. brandtiana Gervais, 1837, and S. pella Wood, 1861; and under S. viridicornis Newport, 1844, S. punctidens Newport, 1844. The following generic assignments are confirmed: S. lobidens Newport, 1844, in Cormocephalus Newport, 1845; and S. cormocephalina Kohlrausch, 1878, S. longipleura Silvestri, 1895, and S. chilensis & S. pallida, both by Gervais, 1847, in Hemiscolopendra Kraepelin, 1903. Scolopendra viridicornis Newport, 1844, a plausible inhabitant of Guyana, is deleted from Cuba and the Lesser Antilles. The publication date of S. alternans Leach, previously thought to be 1813, is corrected to 1815, and that of S. arthrorhabdoides Ribaut, previously cited as both 1912 and 1914, is established as 1913.
Two new and exceptional poison dart frogs of the genus Dendrobates (Anura: Dendrobatidae) from the Northeastern Flank of the cordillera Central of Colombia
Authors: RUEDA-ALMONACID JOSÉ VICENTE , RADA MARCO , SÁNCHEZ-PACHECO SANTIAGO J. , VELÁSQUEZ-ÁLVAREZ ÁLVARO ANDRÉS , QUEVEDO ALONSO 
Published: March 2024

We name and describe two new species of poison dart frogs of the genus Dendrobates, from the northeastern flank of the cordillera Central in the departamentos de Tolima and Caldas. Those frogs share an exceptional synapomorphy within the family, which consists of a first toe reduced and fused with the second toe, allowing only four toes to be seen externally. Perhaps this unusual characteristic is reason to create a new genus within the Dendrobatidae, however, this must await a period of further investigation of the phylogeny of these two species, including a molecular and anatomic analysis. Elucidating the taxonomic position of these species and the naming a new genus, if found to be appropriate and applicable, will be the subject of a future manuscript.
A proposal for reducing maximum target doses of drugs for psychosis: Reviewing dose–response literature
Authors: O’Neill James R. , Jameson Adam , McLean Samantha L. , Dixon Michael , Cardno Alastair G. , Lawrence Christopher 
Published: March 2024

Background: Presently, there is limited guidance on the maximal dosing of psychosis drugs that is based on effectiveness rather than safety or toxicity. Current maximum dosing recommendations may far exceed the necessary degree of dopamine D2 receptor blockade required to treat psychosis. This may lead to excess harm through cognitive impairment and side effects. Aims: This analysis aimed to establish guidance for prescribers by optimally dosing drugs for psychosis based on efficacy and benefit. Methods: We used data from two dose–response meta-analyses and reviewed seven of the most prescribed drugs for psychosis in the UK. Where data were not available, we used appropriate comparison techniques based on D2 receptor occupancy to extrapolate our recommendations. Results: We found that the likely threshold dose for achieving remission of psychotic symptoms was often significantly below the currently licensed dose for these drugs. We therefore recommend that clinicians are cautious about exceeding our recommended doses. Individual factors, however, should be accounted for. We outline potentially relevant factors including age, ethnicity, sex, smoking status and pharmacogenetics. Additionally, we recommend therapeutic drug monitoring as a tool to determine individual pharmacokinetic variation. Conclusions: In summary, we propose a new set of maximum target doses for psychosis drugs based on efficacy. Further research through randomised controlled trials should be undertaken to evaluate the effect of reducing doses from current licensing maximums or from doses that are above our recommendations. However, dose reductions should be implemented in a manner that accounts for and reduces the effects of drug withdrawal.
Immunogenicity and adverse events of the COVID-19 vaccines in healthy and individuals with autoimmune diseases in an Iranian population
Authors: Moradi Hasan-Abad Amin , Arbabi Mohsen , Gilasi Hamidreza , Motedayyen Hossein 
Published: March 2024

Introduction: Recent studies have proposed various COVID-19 vaccines to control the disease and protect susceptible individuals. However, immunogenicity and safety of COVID-19 vaccines in various populations are not well identified yet. Therefore, this study aimed to elucidate the efficacy and safety of the BBIBP-CorV (Sinopharm) and ChAdOx1 nCoV-19 (Oxford-AstraZeneca) vaccines in healthy subjects and patients with autoimmune diseases. Methods: Study population included 121 healthy subjects and 100 patients with autoimmune diseases. Immunization was performed based on the national vaccination protocols. Of the 221 volunteers, 201 subjects received Sinopharm and 20 cases were vaccinated with Oxford-AstraZeneca. During a 1-year follow-up, the immunogenicity was measured by ELISA before primary vaccination and 1 to 3 months after secondary immunization. Side effects were studied before entering the study and 1 week after the second dose. Results: Vaccination had a positive impact on the induction of immunogenic response ( p < .0001). The rates of seropositive vaccine responses were 80% and 75% in subjects vaccinated with the Sinopharm and Oxford-AstraZeneca, respectively. The neutralizing antibody values were significantly higher in subjects with autoimmune diseases than those without autoimmunity ( p < .05). The rate of adverse events were 38% and 42% in subjects vaccinated with the Sinopharm and Oxford-AstraZeneca, respectively. The rates of immunogenic responses induced with the Sinopharm and Oxford-AstraZeneca were, respectively, 76% and 81.5% in seropositive subjects, while they were 63.8% and 79.1% in seronegative subjects vaccinated with the Sinopharm and Oxford-AstraZeneca, respectively. Individuals previously infected with SARS-CoV-2 showed a significant reduction in the value of SARS-CoV-2 neutralizing antibodies compared with seronegative subjects ( p < .01–.05). Seropositive individuals vaccinated with the Sinopharm had significantly higher the percentages of vaccine-related adverse events than seronegative persons ( p < .05). There was no significant difference between seronegative and seropositive individuals vaccinated with the Oxford-AstraZeneca. Conclusion: Our findings revealed that the Sinopharm and Oxford-AstraZeneca vaccines are effective in the production of neutralizing antibodies in healthy subjects and patients with autoimmune disorders undergoing immunosuppressive therapies without considerable reactogenicity.
Addressing infection prevention and control in Alabama through the long-term care strike team
Authors: Fifolt Matthew , Baker Natalie , Menefee R Wade , Kidd Elena , McCormick Lisa C 
Published: March 2024

The COVID-19 pandemic exposed the lack of infection prevention and control (IPC) infrastructure among long-term care facilities (LTCFs) in the United States; the situation in Alabama is particularly dire with LTCFs receiving some of the lowest quality ratings in the country. Alabama’s LTCFs continue to be challenged by frequent staff turnover, vaccine hesitancy, and reluctance to embrace new Centers for Disease Control and Prevention (CDC) recommendations such as enhanced barrier precautions. However, the American Rescue Plan of 2021 made funds available to states through a CDC Epidemiology and Laboratory (ELC) Cooperative Agreement to promote IPC system improvement, including the creation of the Alabama Nursing Home and Long-Term Care Strike Team (LTC Strike Team). In this article, we reviewed preliminary data from Alabama for the first year of the 2-year cooperative agreement cycle (2022––2023). Data included activity tracking by Infection Preventionists (IPs) and evaluations submitted voluntarily by LTCFs upon completion of trainings and/or direct services provided by the LTC Strike Team. Results indicated a significant need for IPC training among LTCFs and a high level of satisfaction with the services provided by IPs. Despite successes, it is unclear if future funding will be available to support long-term sustainability efforts.
Cost-Effectiveness of Closed-Loop Automated Insulin Delivery Using the Cambridge Hybrid Algorithm in Children and Adolescents with Type 1 Diabetes: Results from a Multicenter 6-Month Randomized Trial
Authors: Fox D. Steven , Ware Julia , Boughton Charlotte K , Allen Janet M. , Wilinska Malgorzata E , Tauschmann Martin , Denvir Louise , Thankamony Ajay , Campbell Fiona , Wadwa R. Paul , Buckingham Bruce A. , Davis Nikki , DiMeglio Linda A. , Mauras Nelly , Besser Rachel E. J. , Ghatak Atrayee , Weinzimer Stuart A. , Kanapka Lauren , Kollman Craig , Sibayan Judy , Beck Roy W. , Hood Korey K. , Hovorka Roman 
Published: March 2024

Background/Objective: The main objective of this study is to evaluate the incremental cost-effectiveness (ICER) of the Cambridge hybrid closed-loop automated insulin delivery (AID) algorithm versus usual care for children and adolescents with type 1 diabetes (T1D). Methods: This multicenter, binational, parallel-controlled trial randomized 133 insulin pump using participants aged 6 to 18 years to either AID (n = 65) or usual care (n = 68) for 6 months. Both within-trial and lifetime cost-effectiveness were analyzed. Analysis focused on the treatment subgroup (n = 21) who received the much more reliable CamAPS FX hardware iteration and their contemporaneous control group (n = 24). Lifetime complications and costs were simulated via an updated Sheffield T1D policy model. Results: Within-trial, both groups had indistinguishable and statistically unchanged health-related quality of life, and statistically similar hypoglycemia, severe hypoglycemia, and diabetic ketoacidosis (DKA) event rates. Total health care utilization was higher in the treatment group. Both the overall treatment group and CamAPS FX subgroup exhibited improved HbA1C (−0.32%, 95% CI: −0.59 to −0.04; P = .02, and −1.05%, 95% CI: −1.43 to −0.67; P < .001, respectively). Modeling projected increased expected lifespan of 5.36 years and discounted quality-adjusted life years (QALYs) of 1.16 (U.K. tariffs) and 1.52 (U.S. tariffs) in the CamAPS FX subgroup. Estimated ICERs for the subgroup were £19 324/QALY (United Kingdom) and −$3917/QALY (United States). For subgroup patients already using continuous glucose monitors (CGM), ICERs were £10 096/QALY (United Kingdom) and −$33 616/QALY (United States). Probabilistic sensitivity analysis generated mean ICERs of £19 342/QALY (95% CI: £15 903/QALY to £22 929/QALY) (United Kingdom) and −$28 283/QALY (95% CI: −$59 607/QALY to $1858/QALY) (United States). Conclusions: For children and adolescents with T1D on insulin pump therapy, AID using the Cambridge algorithm appears cost-effective below a £20 000/QALY threshold (United Kingdom) and cost saving (United States).