bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ruxolitinib plus basiliximab therapy for steroid-refractory acute graft-versus-host disease in unrelated cord blood transplantation: a large-scale study
Authors: Zhu Xiaoyu , Wu Yue , Sun Guangyu , Tang Baolin , Song Kaidi , Cheng Yaxin , Tu Meijuan 
Published: March 2024

Abstract

Steroid-refractory (SR) acute graft-versus-host disease(aGVHD) is a major cause of mortality after allogeneic stem cell transplantation (allo-HSCT). We aimed to evaluate the effectiveness and safety of ruxolitinib plus basiliximab for treating SR-aGVHD after unrelated cord blood transplantation (UCBT). Among the 1154 patients with hematological malignancies who underwent UCBTbetween February 2014 and May 2022, 198 patients with grade II to IV SR-aGVHD were enrolled, 112 of whom were treated with basiliximab alone (basiliximab group) and 86 of whom received basiliximab plus ruxolitinib (combined therapy group). The combined therapy group demonstrated a significantly higher complete response rate (CRR) on day 28 (36.0%) than did the basiliximab group (12.5%, P < 0.001). SR-aGVHD patients were further stratified into standard-risk and high-risk groups using the refined Minnesota aGVHD risk score. For standard-risk patients, combined therapy significantly improved the CRR (51.1% versus 13.6%, P < 0.001) and 3-year overall survival (74.5% versus 52.4%, P = 0.033). However, high-risk patients did not exhibit the same benefits. Compared with basiliximab monotherapy, ruxolitinib plus basiliximab therapy was an effective therapy for patients with standard-risk SR-aGVHD following UCBT. The effectiveness of combined therapy in high-risk patients was not apparent, indicating the need for other treatments.
Socio environmental determinants of cardiovascular mortality and hospitalization risk in arid and semi-arid regions – a case study for Gonabad city,Iran 2017-2022
Authors: Mohamadpour Ali , Rezaei Zahed , Parvari Arash , Rodriguez-Couto Susana , Alami Ali , khosravan Shahla , Kalankesh Laleh R. 
Published: March 2024

Abstract

Background
Since questioning regarding climate and incidents of cardiovascular rates have been debated. This study was designed to investigate the association between cardiovascular mortality hospitalization risk and demographic-meteorological factors in the arid and semi-arid zone of Iran during (1st April 2017 and 31st December 2022).
Methods
Logistic and negative binomial regression and Pearson regression were used for analysis.
Results
A mean age of 61.52 years old (49.5% female and 50.5% male) was recorded for the hospitalization. Peak numbers of daily hospitalization were observed in winter (18%), followed by autumn (16%). Cardiovascular hospitalization presented a significant positive correlation with the wind (P = 0.05) and temperature (P = 0.016) in the hot season, whereas showing a negative correlation with humidity (P = 0.013) and wind factor (P = 0.05) in the cold season. Similarly, a negative correlation between cardiovascular mortality and speed of wind (P = 0.05) was observed in summer.
Conclusion
It concluded that there were associations between demographic-meteorological factors and the occurrence of cardiovascular hospitalization-mortality in arid and semiarid region.
Genome-wide association mapping and candidate genes analysis of high-throughput image descriptors for wheat frost resistance
Authors: Wu Jianhui , Yu Rui , Liu Yixue , Yuan Meng , Jiang Pingtao , Zhao Jiwen , Zhang Chuanliang , Xu Xiaowan , Wang Qilin , Wang Yuze , Chen Tiantian , Kang Zhensheng , Zeng Qingdong , Zhao Yusheng , Su Baofeng , Han Dejun 
Published: March 2024

Abstract

Frost risk is increasingly occurring in winter wheat. Quantitative assessment of frost risk can facilitate the analysis of key genetic factors related to wheat resistance to abiotic stress. We collected 491 wheat accessions and selected four image-based descriptors (BLUE band, RED band, NDVI, and GNDVI) to quantitatively assess their frost risk. Image descriptors can complement the visual estimation of frost risk. Combined with GWAS, a total of 107 quantitative trait loci (QTL) (r2 ranging from 0.75% to 9.48%) were identified, including the well-known frost-resistant locus Frost Resistance (Fr)-1/ Vernalization (Vrn)-1. Additionally, by utilizing published RNA-Seq data, we identified two other frost resistance candidate genes TraesCS2A03G1077800 and TraesCS5B03G1008500. Furthermore, when combined with genome selection (GS), image-based descriptors can predict frost risk with high accuracy (r≤0.84). In conclusion, our research confirms the accuracy of image-based high-throughput acquisition of frost risk, thereby supplementing the exploration of the genetic structure of frost resistance in wheat within complex field environments.
Impact of Beta Cyclodextrin-Encapsulated Zinc Oxide Nanoparticles as Heterogeneous Catalysts in Microbial Oil Production: An Investigation
Authors: . R. Janice , . A. Dayanandan , . K.Viswanathan 
Published: March 2024

Abstract

The catalytic activity of beta cyclodextrin encapsulated zinc oxide (ZnO) nanoparticles in microbial oil synthesis was investigated utilizing Streptomyces fradiae as the microbe and rice washed waste water (RWW) as the fermentation medium.Zinc oxide nanoparticles introduced during fermentation influenced growth and production. When compared to control samples, the biomass percentage was 1.5 times higher, and the fatty acid profile was improved. The induction period (IP) investigation demonstrated that zinc oxide nanoparticles provided the highest oxidation stability up to 120 days of storage while also significantly reducing autoxidation. However, the inclusion of ZnO nanoparticles increased the cetane number and calorific value. A new study found that employing β-CD encapsulated ZnO nanoparticles in microbial oil production resulted in much higher production (63.5g/L) than the control sample (42.5g/L). As a result, these nanoparticles are predicted to be useful in energy-related applications.
Cultural adaptation of the ENABLE (Educate, Nurture, Advise, Before Life Ends) as an early palliative care model among heart failure patients and caregivers in Iran: A qualitative study protocol
Authors: Mirshahi Arvin , Khanipour-Kencha Ali , Bakitas Marie , Odom J. Nicholas , Wells Rachel , Manookian Arpi 
Published: March 2024

Abstract

Introduction: ENABLE (Educate, Nurture, Advise, Before Life Ends) is a model of nurse-led, early palliative care that was originally developed for U.S. patients with advanced cancer and their family caregivers and then adapted for patients with heart failure. ENABLE coaching topics include problem-solving, communication, advance care planning, symptom management, and self-care. The purpose of this paper is to detail a qualitative study protocol to assess the cultural acceptability of ENABLE among heart failure patients and their family caregivers in Iran.
Methods and analysis: This is a qualitative study employing a thematic analysis approach. In the first phase, the translation and validation of ENABLE model contents will be conducted using the standard forward-backward method and an expert panel. In the second phase, through the purposive sampling method and by using semi-structured interviews, approximately 45 participants including heart failure patients (n≈15), their family caregivers (n≈15), and healthcare professionals involved in their care (n≈15) will be invited to participate in one-on-one semi-structured interviews exploring three main areas: (1) the primary needs and challenges faced by individuals with heart failure and their family caregivers, (2) the extent of patients’ involvement in healthcare decision-making, and (3) participants’ preferences for content and delivery method of ENABLE. Interview audio recordings will be transcribed verbatim and data will be analyzed using Clarke and Braun thematic analysis method including 1) Familiarization with the data, 2) Generating initial codes, 3) Searching for themes, 4) Reviewing themes, 5) Defining and naming themes, and 6) Preparing the report/manuscript. Study rigor will be assessed based on Lincoln and Guba’s gold standards: credibility, dependability, confirmability, and transferability.
Ethics and dissemination: Ethical approval has been granted by Institutional Review Board at Tehran University of Medical Sciences (IR.TUMS.FNM.REC.1401.133). We expect to disseminate study findings through journal articles, conference presentations, and public and social multimedia.
Female Labor Force Participation in Bangladesh and Neighboring Indian States
Authors: Chakraborty Shankha , Siddiqui Shihab 
Published: March 2024

Abstract

The female labor force participation rate in South Asia, already among the lowest in the world, has been falling in several countries. In an attempt to understand the sources of this pattern, we use a decomposition method to compare the experience of Bangladesh during 1991-2011 with that of neighboring Indian states during 1987-2009. The results point to the role of structure change: changes in women's employment rate in the neighboring Indian states was driven more by changes in opportunities in the agricultural sector relative to Bangladesh. At the same time, changes beyond economic opportunity alone may have played a significant role: women's education led to increased labor force participation in Bangladesh, while the opposite was true in the Indian states.
JEL CODES: J21, J24, O35 I12, I15, Z1
Update on the taxonomy of Clavulina in China Ⅰ: description of three new species and one newly recorded species
Authors: Liu Xiangfen , Deng Peng Tao , Yan Jun , Zhang Ping 
Published: March 2024

Abstract

Specimens of three newly discovered species of Clavulina, and the previously described species C. thindii, were collected during field surveys in southwestern China. The specimens were used for examination of morphological characters and DNA extraction for molecular phylogenetic analyses. Phylogenetic analysis of concatenated sequences for the nuclear ribosomal DNA internal transcribed spacer region, nuclear ribosomal RNA large subunit, and the RNA polymerase II subunit B gene revealed that the three new species each formed a distinct lineage in the Clavulina clade. The samples of C. thindii from China and India formed a monophyletic lineage. The three new species are formally described here. Clavulina curva has noticeably distorted basidiomata, C. spina has uniform spines on the basidioma surface, and C. yunnanensis has brownish gray to dark black-brown stipes, with rare longitudinal corrugations and bristles. A key to known Clavulina species in China, descriptions of the macromorphology, micromorphology, and habitat for the four Clavulina species are provided.
Effects of inulin on intestinal flora and metabolism-related indicators in obese polycystic ovary syndrome patients
Authors: Gao Ting , Jiang Bo , Nian Yan , Bai Xing , Zhong Jiawen , Qin Ling , Gao Zhengzheng , Wang Hao , Li Xiaorong 
Published: March 2024

Abstract
Context:
Polycystic ovary syndrome (PCOS), a common endocrine disorder in women of reproductive age, is closely associated with chronic low-grade inflammation and metabolic disturbances. In PCOS mice, dietary inulin has been demonstrated to regulate intestinal flora and inflammation. However, the efficacy of dietary inulin in clinical PCOS remains unclear.
Objective
The intestinal flora and related metabolic indexes of obese patients with polycystic ovary syndrome (PCOS) after 3 months of inulin treatment were analyzed.
Setting and design:
To analyze the intestinal flora and related metabolic indexes in healthy controls and obese patients with polycystic ovary syndrome after 3 months of inulin treatment.
Results
The results showed that dietary inulin improved sex hormone disorders, reduced BMI and WHR levels in obese women with PCOS. In addition, the inulin intervention reduced plasma TNF-α, IL-1β, IL-6, and MCP-1levels. Inulin intervention increased the abundance of Actinobacteria, Fusobacteria, Lachnospira, and Bifidobacterium, as well as decreased the ratio of F/B and the abundance of proteobacteria, Sutterella, and Enterobacter.Correlation analyses showed a strong relationship among plasma inflammatory factors, sex steroid hormones, and the intestinal flora of patients.
Conclusions
Dietary inulin may improve obese PCOS women disease through the gut flora-inflammation-steroid hormone pathway.
Role of metabolites in mediating the effect of lipidomes on rheumatoid arthritis
Authors: wu Chengjiang , Cai Xiaojie 
Published: March 2024

Abstract
Background
Evidence from observational studies and clinical trials suggests that lipidomes are associated with an increased risk of rheumatoid arthritis (RA). However, considering inherent confounding factors and the challenge of reverse causality in observational studies, the direct causal relationship between lipidomes and RA remains unknown. Therefore, we conducted mendelian randomization (MR) as well as mediation analysis to elucidate the causal relationship among lipidomes, RA, and metabolites as a mediator.
Methods
The bidirectional MR analysis was performed to evaluate the relationship of lipidomes and RA, with a focus on the role of metabolites. Instrumental variables (IVs) were used as the central methodological technique, supplemented by MR-Egger, weighted median, simple mode, as well as weighted mode methods.
Results
Findings from this study revealed that six lipidomes had a positive correlation with RA, while one showed a negative association. Furthermore, mediation MR analysis results revealed that undecenoylcarnitine (C11:1) served as a mediator for the effect of sterol ester (27:1/20:4) on RA and the mediation effect was calculated to be 7.98%.
Conclusions
Our study demonstrated the genetic causal effect of lipidomes on RA, emphasizing the potential mediating role of undecenoylcarnitine (C11:1) and providing insights for the clinical intervention of RA.
Spatio-Temporal Variations in Groundwater Quality of Upland Area, West Godavari District, Andhra Pradesh Using Interpolation Techniques
Authors: Rambabu T. , Kumar L. V. Ravi , Suribabu G. , Raghuram P. , Raju PARK 
Published: March 2024

Abstract

The water quality is a basic necessity in upland areas for all anthropogenic and livestock activities. At present, there is increasing pressure on groundwater for supplying treated drinking water to the public in all villages and urban areas. Increasing number of bore wells also mounting pressure on the ground water due to intensive agriculture and horticulture practices. Human interferences in water resources causes deterioration of water quality which is detrimental to human and livestock health. The present study evaluates the physico-chemical and biological parameters of groundwater in upland area of West Godavari district. A total of thirty samples from thirty villages in pre and post monsoon seasons of 2017 were collected and analyzed for pH, Electrical Conductivity, Total Dissolved Solids, Total Hardness, Calcium, Total Alkalinity, Magnesium, Chloride, Sulphate, Dissolved Oxygen and Biochemical Oxygen Demand. GIS based Inverse distance weighted (IDW) interpolation techniques are used for spatio-temporal correlation. Water Quality Index (WQI) was calculated by using all physico-chemical and biological parameters to assess the quality of groundwater. WQI of 47.91 during the pre-monsoon period approves the overall quality groundwater is fit for human consumption whereas WQI of 57.67 in post monsoon season indicates the poor quality of ground water. As per the WQI ratings, 49.99% (≈ 50%) of samples during pre-monsoon and 66.66% of samples during post monsoon seasons were ranging from excellent to good in quality. GIS based interpolation techniques approve that North-West (NW) and South-East (SE) portions during pre-monsoon, South-West (SW) portions during post monsoon are in excellent (WQI is < 25) to good (WQI is in between 26–50) range. IDW discloses the spatial distribution of quality groundwater and WQI approves the potability of the groundwater. The two proven methods allow the users for informed decisions in accessing the water for several uses.
Identification of glycolysis related genes for prognosis prediction in patients with breast cancer
Authors: Chao Shuai , Liu Shiqiang , Wang Kun , Xie Mingming , Liu Beibei 
Published: March 2024

Abstract
Objective
Breast cancer (BC) is a malignant tumor that threatens women’s health. Studies have found that glycolysis is related to the occurrence of BC. However, there is no systematic screening of glycolysis related genes affecting the prognosis of BC.
Methods
BC-related data were downloaded, and analyzed to identify glycolysis related genes that regulate BC. The glycolysis related genes associated with BC prognosis was screened by using Cox regression analysis, and a predictive model was established. The relevant clinical data and model risk scores were analyzed. The correlation graph of the model with tumor characteristics data and survival rate was obtained.
Results
A total of seven glycolysis related genes (AK3, PGK1, SDC3, NUP43, CACNA1H, SDC1, and IL13RA1) that affect BC patients’ prognosis were authenticated, and they were divided into high-risk and low-risk groups. For overall survival rate, patients with low-risk score were higher than patients with high-risk score. The correlation analysis of risk scores and clinical data showed that the constructed model could be used to predict the prognosis of BC patients.
Conclusion
The seven glycolysis related genes can predict BC prognosis, and may provide new targets for the treatment of BC.
The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome
Authors: hamidi hediyeh , Kheirollahi Asma , Vatannejad Akram 
Published: March 2024

Abstract

Background Polycystic ovarian syndrome (PCOS) stands as the most prevalent endocrine disorder among women of reproductive age. Vitamin D binding protein (VDBP) is a polymorphic protein with a crucial role in vitamin D metabolism. This study aimed to examine the association of rs7041 polymorphism with PCOS, as well as infertility and recurrent pregnancy loss (RPL) in PCOS patients. Methods A total of 200 women diagnosed with PCOS, including 100 infertile and 100 with a history of recurrent pregnancy loss, and 100 fertile women were enrolled in this study. Blood samples were taken from these individuals, and their biochemical and hormonal profiles were assessed. Genotyping for the rs7041 polymorphism was carried out in the study population using the PCR-RFLP method. Results Genotype analysis showed that the GT genotype and the T allele of the rs7041 polymorphism were associated with an elevated risk of PCOS (OR: 2.8 95% CI [1.48–5.33], p = 0.002, and OR: 2.27 95% CI [1.2–4.28], p = 0.01, respectively). Furthermore, the GT genotype and T allele of the rs7041 polymorphism were associated with an increased risk of infertility in PCOS women (OR: 40.55 95% CI [5.34–307.7], p < 0.0001, and OR: 30.667 95% CI [4.05-232.19], p = 0.001, respectively). Conversely, no significant association was observed between genotypes and RPL in women with PCOS. LH levels were significantly higher in individuals with the T allele compared to those with the G allele. Conclusion The study results highlight a significant correlation between the rs7041 polymorphism in the VDBP gene and the risk of PCOS and infertility.
Surgical Procedures Predicting Postoperative Outcomes in Elderly Patients with non-Emergency Colorectal Cancer Surgery
Authors: Chen Guanchi , Liang Zhonglin , Cui Long 
Published: March 2024

Abstract

Backgroud:
Elderly patients are at an increased risk for morbidity and prolonged hospital stay with non-emergency colorectal cancer surgery. We aimed to determine which surgical procedures would be associated with postoperative morbidity or shorter postoperative hospital stay in elderly colorectal patients.
Methods:
We performed an observational study of elderly patients, older than 75 years old, treated at a single institution in Shanghai.The postoperative outcomes of our study were incidence of all complications. Odds ratios were estimated by logistic regression models. Postoperative hospital stay was evaluated by negative binomial regression model. Post-estimations were calculated.
Results:
The cohort consisted of 442 patients. Incidence of postoperative complication was 44.34%. Anastomosis ( OR 0.465; 95%CI 0.241 to 0.897; P = 0.022) was associated with lower incidence of postoperative complications. Patients with laparoscopy had decreased surgery related complications (Adjusted OR, 0.567; 95% CI, 0.331 to 0.972; P = 0.039). Patients with stoma had prolonded hospital stay (IRR 1.172; 95%CI 1.023 to 1.344; P = 0.023).
Conclusion:
Surgical procedures predict improved postoperative outcomes. Further studies would be warranted.
Investigating Safety Incidents with High-Risk Medications: Insights from the National Reporting and Learning System (NRLS) on Opioids, Insulins, and Anticoagulants
Authors: Alrowily Abdulrhman , Alfaraidy Khalid , Almutairi Saleh , Alamri Abdullah , Alrowily Wejdan , Abutaleb Mohammed , Zaitoun Mohammad , Sarawi Wedad , Aljead Mashael 
Published: March 2024

Abstract
Background
Ensuring patient safety is paramount in any healthcare system. Rising concerns about medical errors in the UK have necessitated greater focus to be placed on studying the nature of such errors, particularly those involving high-risk medications. This research aims to conduct a retrospective analysis of incidents related to patient safety in the UK, based on data from the NRLS.
Methods
This research was conducted based on the review of NRLS patient safety reports published during the period January 1st, 2015 to December 31st, 2015. NHS Improvement provided details regarding the incidents, following approval using a data-sharing agreement. In total, 1,500 incidents were analyzed, equally divided among three categories of high-risk drugs; opioids, insulin and anticoagulants. Excel features and deductive reasoning (thematic analysis) were used in the data analysis.
Results
The results showed that the insulin category had both the highest risk and the most errors compared to anticoagulants and opioids. These errors primarily resulted from issues in administering, prescribing, and dispensing drugs. Inadequate drug checks, communication difficulties among staff and with patients, and high staff workload were often linked to these errors.
Conclusion
This study confirms that the NRLS database is a valuable source of data, while the suggestions put forth, based on these results, could contribute to the formulation of measures that diminish the occurrence of errors related to high-risk drugs in healthcare settings. Information technology should enhance medication safety by tracking the processing of medication use.