bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coupled Ocean–Atmosphere–Ice Response to Variations in the Southern Annular Mode
Authors: Sen Gupta Alexander , England Matthew H. 
Published: September 2006

Abstract
The coupled ocean–atmosphere–ice response to variations in the Southern Annular Mode (SAM) is examined in the National Center for Atmospheric Research (NCAR) Community Coupled Climate Model (version 2). The model shows considerable skill in capturing the predominantly zonally symmetric SAM while regional deviations between model and observation SAM winds go a long way in explaining the generally small differences between simulated and observed SAM responses in the ocean and sea ice systems. Vacillations in the position and strength of the circumpolar winds and the ensuing variations in advection of heat and moisture result in a dynamic and thermodynamic forcing of the ocean and sea ice. Both meridional and zonal components of ocean circulation are modified through Ekman transport, which in turn leads to anomalous surface convergences and divergences that strongly affect the meridional overturning circulation and potentially the pathways of intermediate water ventilation. A heat budget analysis demonstrates a conspiring of oceanic meridional heat advection, surface heat fluxes, and changes in mixed layer depth, which acts in phase to imprint a strong circumpolar SAM signature onto sea surface temperatures (SSTs), while other oceanic processes, including vertical advection, are shown to play only a minor role in contrast to previous suggestions. Lagged correlations show that although the SAM is mainly controlled by internal atmospheric mechanisms, the thermal inertia of the ocean reimprints the SAM signature back onto surface air temperatures (SATs) on time scales longer than the initial atmospheric signal. Sea ice variability is well explained by a combination of atmospheric and oceanic dynamic and thermodynamic forcing, and by an albedo feedback mechanism that allows ice extent anomalies to persist for many months. Nonzonally symmetric components of the SAM winds, particularly in the region surrounding the Antarctic Peninsula, have important effects for other climate variables.
Simulated Global-Mean Sea Level Changes over the Last Half-Millennium
Authors: Gregory J. M. , Lowe J. A. , Tett S. F. B. 
Published: September 2006

AbstractSimulations of the last 500 yr carried out using the Third Hadley Centre Coupled Ocean–Atmosphere GCM (HadCM3) with anthropogenic and natural (solar and volcanic) forcings have been analyzed. Global-mean surface temperature change during the twentieth century is well reproduced. Simulated contributions to global-mean sea level rise during recent decades due to thermal expansion (the largest term) and to mass loss from glaciers and ice caps agree within uncertainties with observational estimates of these terms, but their sum falls short of the observed rate of sea level rise. This discrepancy has been discussed by previous authors; a completely satisfactory explanation of twentieth-century sea level rise is lacking. The model suggests that the apparent onset of sea level rise and glacier retreat during the first part of the nineteenth century was due to natural forcing. The rate of sea level rise was larger during the twentieth century than during the previous centuries because of anthropogenic forcing, but decreasing natural forcing during the second half of the twentieth century tended to offset the anthropogenic acceleration in the rate. Volcanic eruptions cause rapid falls in sea level, followed by recovery over several decades. The model shows substantially less decadal variability in sea level and its thermal expansion component than twentieth-century observations indicate, either because it does not generate sufficient ocean internal variability, or because the observational analyses overestimate the variability.
Bottom Layer Turbulence in the Red Sea Outflow Plume
Authors: Peters Hartmut , Johns William E. 
Published: September 2006

AbstractTurbulence in the Red Sea outflow plume in the western Gulf of Aden was observed with an upward-looking, five-beam, 600-kHz acoustic Doppler current profiler (ADCP). The “Bottom Lander” ADCP was deployed on the seafloor in two narrow, topographically confined outflow channels south of Bab el Mandeb for periods of 18–40 h at three locations at 376-, 496-, and 772-m depths. Two deployments were taken during the winter season of maximum outflow from the Red Sea and two in the summer season of minimum outflow. These short-term observations exhibit red velocity spectra with high-frequency fluctuations of typically a few centimeters per second RMS velocity during strong plume flow as well as strong subtidal variations. In one winter season event, the plume flow was reduced by a factor of 4 over an 18-h time span. In variance-preserving form, velocity spectra show a separation at frequencies of 0.3–3 cycles per hour between low-frequency and high-frequency signals. The latter show significant coherence between horizontal and vertical velocity components; hence they carried turbulent stress. Based on a comparison with velocity spectra from atmospheric mixed-layer observations, the authors argue that large variance at frequencies of the order of 1 cph was possibly associated with bottom-generated, upward-propagating internal waves. One coherent feature that matched such waves was observed directly. Higher frequencies correspond to turbulent motions of energy-carrying scales. The turbulent Reynolds stress at heights above the bottom between 4 and 30–40 m was computed for most of the ADCP observations. Near the bottom, the streamwise turbulent stress and the streamwise velocity followed a quadratic drag law with drag coefficients ranging from 0.002 to 0.008. There was also significant spanwise stress, hinting at the three-dimensional nature of the boundary layer flow. The time–height variations of the stress and its spectrum proved to be complex, one of its most striking features being angles of up to ∼40° between the direction of the stress and that of the low-frequency flow. The turbulent shear production and eddy viscosity were also examined. On the technical side, the paper discusses the role of the fifth, center-beam velocity measurements in correcting for instrument tilt along with the effect of beam spreading in the 30° Janus configuration of the “regular” four ADCP beams. Instrumental noise and detection limits for the stress are also established.
Kaolin and halloysite deposits of Brazil
Authors: Wilson I. R. , de Souza Santos H. , de Souza Santos P. 
Published: September 2006

AbstractBrazil is a significant producer of kaolin with almost 2.5 Mt in 2005 representing 10% of the world's total of 25.0 Mt. Brazil is now the second largest producer in the world, after the USA, having overtaken the United Kingdom in 2005. The kaolin resources are widespread throughout the country and are varied in their origin, physical and chemical properties and morphology. The kaolin industry in Brazil has shown a dramatic rise over the last 15 years with production of beneficiated kaolin increasing from 0.66 Mt in 1990 to 2.5 Mt in 2005. The reason for the growth is solely the development of large kaolin deposits in the Amazon Basin that account for 90% of Brazil's production. In 2005 there are just two companies involved in the production and sales of kaolin from the Amazon Basin, namely Imerys (RCC — Rio Capim Caulim) and Caemi (a subsidiary of CVRD — Companhia Vale do Rio Doce) with kaolin operations of CADAM (Jari River) and PPSA (Capim River operations).
A method for determining the CEC and chemical composition of clays via XRF
Authors: Battaglia S. , Leoni L. , Sartori F. 
Published: September 2006

AbstractA new method for determining the cation exchange capacity (CEC) of clays is proposed. The method is based on X-ray fluorescence analysis of natural and Ba-exchanged clays following the analytical procedure suggested by Franzini et al. (1975). This procedure, which utilizes powder pellets and is based on a full matrix correction method, is frequently applied in Earth Sciences laboratories for the routine analysis of minerals and rocks. For the analysis of Ba-exchanged clays, Franzini's procedure has been modified slightly to account for the contribution of Ba to matrix effects.The new method, which furnishes both the CEC and the chemical compositions of the whole natural clay samples, has been tested on the eight ‘Source Clays’ of The Clay Minerals Society. The results compare well with data reported in the literature and confirm the accuracy and precision of the method and make it a valid alternative to techniques based on wet chemistry, execution of which is usually more time-consuming and which often requires greater analytical skill.
Clay minerals as dynamic tracers of suspended matter dispersal in the Gulf of Cadiz (SW Spain)
Authors: Gutiérrez-Mas J. M. , López-Aguayo F. , Achab M. 
Published: September 2006

AbstractThe dispersal of suspended matter in the Gulf of Cadiz (SW Spain) is related to its geographical position near the Strait of Gibraltar, and the continental margin, and to Atlantic and Mediterranean water flows and their interaction with the littoral tidal processes. The main direction for transport of suspended matter is towards the southeast, along the continental margin, from the mouths of the rivers Guadiana and Guadalquivir to the Mediterranean. This general transport pattern is perturbed by littoral processes such as those occurring in Cadiz Bay, where a portion of Atlantic suspended matter, driven by flood tide, comes into the inner bay and is deposited in the shallow waters of lagoons and salt marshes. Subsequently, because of the southeast wind and waves, these sediments are remobilized and transported to the west by the ebb tide, to deeper Atlantic waters. This dynamic interaction between Atlantic and littoral waters generates a different type of sediment layout, the origin of which is difficult to establish.In order to understand the dispersal of the suspended matter and its effects on the inner continental shelf, the distribution of the main clay minerals has been determined by means of X-ray and Q-mode and R-mode factor analysis. The suspended matter dispersal paths were established through the distribution of main clay mineral associations and from the ratios amongst these minerals. The results allow us to determine the importance of the tidal flows in the suspended matter transport system of the Gulf of Cadiz. Therefore, a record was kept of which of the outgoing tidal flows from the inner parts of Cadiz Bay reached the continental shelf. The flows intercept the clear Atlantic waters giving rise to a complex sediment distribution and to the mix of clay minerals. The study has also allowed us to establish the sediment source areas and the extent of sediment transport and the paths they follow.
Forms of K as a function of clay mineralogy and soil development
Authors: Nabiollahy K. , Khormali F. , Bazargan K. , Ayoubi SH. 
Published: September 2006

AbstractThe relationships between different pools of K, i.e. exchangeable, HN03-extractable, mineral and total, were investigated as a function of clay mineralogy and soil development in soils of Kharkeh Research Station, Kurdestan Province, western Iran. Samples from different horizons often pedons were selected and analysed for clay mineralogy and K fractionation. X-ray diffraction patterns revealed that clay minerals in the soils studied were similar in type, while their abundances were different. The smectite content was significantly greater in Vertisols than in the other soils. The results of K fractionation showed that mineral K and HN03-extractable K (exchangeable and nonexchangeable, respectively) and the clay content of the soils containing lesser illite (10–30%) were significantly different from those with more illite (30–50%). Moreover, the regression slopes between water-soluble and NE4OAc-extractable K were lower in soils with more smectite due mainly to the presence of larger specific surface areas for K sorption in smectitic soils. Based on soil evolution and different forms of K, the soils studied were grouped in two major categories: (1) Vertisols and (2) Entisols, Inceptisols and Mollisols. There were greater contents of all forms of K in Vertisols than in the other soil orders. This was mainly related to the greater clay content and the dominance of smectite in the clay fraction of Vertisols.
Diagenetic history of the Podhale-Orava Basin and the underlying Tatra sedimentary structural units (Western Carpathians): evidence from XRD and K-Ar of illite-smectite
Authors: Środoń J. , Kotarba M. , Biroň A. , Such P. , Clauer N. , Wójtowicz A. 
Published: September 2006

AbstractDiagenesis in the Podhale and Orava Paleogene flysch basins and in the underlying Mesozoic structural units was studied by XRD measurement of the percent smectite in the mixedlayer illite-smectite from shales and K-Ar dating of the illite-smectite from bentonites, supported by XRD quantitative mineral analysis, grain density, and porosity measurements of the bulk shales. The diagenetic mineral reactions identified in the flysch shales include illitization of smectite (>60 to <5%S), dissolution of K-feldspar and kaolinite, crystallization of quartz, albite and chlorite. An unusually large amount of basin history information was obtained by combining the illite-smectite data from wells and from the present erosional surface of the basin.The rocks underwent burial diagenesis at a stable geothermal gradient similar to the present-day value of 21±2°C/km. The maximum burial temperatures were reached very quickly (high sedimentation rate) close to the basin inversion time, at ∼17 Ma in the western part and 18 Ma in the eastern part.The basin floor, which included the present-day Tatra Mts., was inclined towards the East. The thickness of the sedimentary filling of the basin ranged from 3.5–4.5 km in the western Tatra (removed entirely), to 5–6 km in the western Podhale (<3–4 km removed), to 6.5–7.5 km in the eastern Podhale (>4–5 km removed), and even more in the eastern Tatra and Spisská Magura close to the Ružbachy Fault. These data imply a major subsidence followed by uplift of the Podhale plus Tatra block along the Ružbachy Fault and the deposition of a thick sequence of Lower Miocene sediments over the entire area (latter removed by erosion).The Mesozoic rocks of all the structural units underlying the flysch basin underwent advanced diagenesis (maximum palaeotemperatures of 160–270°C) during an Upper Cretaceous tectonic burial event at ∼80–90 Ma. The tectonic overload was removed before the Eocene transgression (49–42 Ma).
Microstructure and properties of stoneware clay bodies
Authors: Flynn A. J. , Stachurski Z. H. 
Published: September 2006

AbstractRaw clay materials manufactured for stoneware use are typically compounds of kaolins, silicas and feldspars. Two stoneware clay materials examined here were chosen because each is representative of the range of manufactured clay bodies. Samples were fired in an oxidizing atmosphere to a range of temperatures between ∼1000 and 1300°C. Sample dimensions, density, porosity and mechanical properties under compression were measured as a function of firing temperature. Thin sections, showing particles and their relationship to pore/void structures, were prepared, recorded under scanning electron microscopy (SEM), and analysed. The observed changes in microstructure can be related to previously described metamorphic and micro-eutectic reactions and a gradual sintering process. Indications of changes to apparent porosity are further amplified by measured changes of mechanical properties. The modulus of elasticity increases with reduction in porosity to a point at which porosity ceases to be the principal determining factor. The critical Griffith's crack length, calculated from fracture-strength measurement, exhibits a similar trend. The onset of these changes coincides with a significant increase in sealed porosity and with the microstructural metamorphosis as revealed by SEM.
A novel electron paramagnetic resonance-based assay for prostaglandin H synthase-1 activity
Authors: Turnbull Catriona M , McClure Danny , Rossi Adriano G , Megson Ian L 
Published: September 2006

Abstract

Background
Prostaglandin H2 synthase (PGHS) is the enzyme that catalyses the two-stage conversion of arachidonic acid to prostaglandin H2 (PGH2) prior to formation of prostanoids that are important in inflammation. PGHS isozymes (-1 and -2) are the target for nonsteroidal anti-inflammatory drugs (NSAIDs).
Given the rekindled interest in specific anti-inflammatory PGHS inhibitors with reduced unwanted side effects, it is of paramount importance that there are reliable and efficient techniques to test new inhibitors. Here, we describe a novel in vitro electron paramagnetic resonance (EPR)-based assay for measuring the activity of PGHS-1.

Methods
We validated a novel in vitro PGHS-1 activity assay based on the oxidation of spin-trap agent, 1-hydroxy-3-carboxy-pyrrolidine (CPH) to 3-carboxy-proxy (CP) under the action of the peroxidase element of PGHS-1. This quantifiable spin-adduct, CP, yields a characteristic 3-line electron paramagnetic (EPR) spectrum.

Results
The assay is simple, reproducible and facilitates rapid screening of inhibitors of PGHS-1. Aspirin (100 μM, 1 mM) caused significant inhibition of spin-adduct formation (72 ± 11 and 100 ± 16% inhibition of control respectively; P < 0.05). Indomethacin (100 μM) also abolished the signal (114 ± 10% inhibition of control; P < 0.01). SA and the PGHS-2-selective inhibitor, NS398, failed to significantly inhibit spin-adduct generation (P > 0.05).

Conclusion
We have demonstrated and validated a simple, reproducible, quick and specific assay for detecting PGHS-1 activity and inhibition. The EPR-based assay described represents a novel approach to measuring PGHS activity and provides a viable and competitive alternative to existing assays.
The influence on the immunomodulatory effects of dying and dead cells of Annexin V
Authors: Munoz Luis E , Franz Sandra , Pausch Friederike , Fürnrohr Barbara , Sheriff Ahmed , Vogt Birgit , Kern Peter M , Baum Wolfgang , Stach Christian , Von Laer Dorothee , Brachvogel Bent , Poschl Ernst , Herrmann Martin , Gaipl Udo S 
Published: September 2006

AbstractApoptotic and necrotic cells expose phosphatidylserine (PS). This membrane modification ensures a swift recognition and uptake by phagocytes of the dying and dead cells. Annexin V (AxV) preferentially binds to anionic phospholipids and thereby, modulates the clearance process. First, we analyzed the influence of AxV on the immunogenicity of apoptotic cells. The addition to apoptotic cells of AxV prior to their injection into mice increased their immunogenicity significantly. Next, we studied the influence of endogenous AxV on the allogeneic reaction against apoptotic and necrotic cells. To preserve heat-labile, short-lived “danger signals,” we induced necrosis by mechanical stress. Wild-type mice showed a strong, allogeneic delayed-type hypersensitivity (DTH) reaction. In contrast, AxV-deficient animals showed almost no allogeneic DTH reaction, indicating that endogenous AxV increases the immune response against dead cells. Furthermore, AxV-deficient macrophages had a higher immunosuppressive potential in vitro. Next, we analyzed the influence of AxV on chronic macrophage infection with HIV-1, known to expose PS on its surface. The infectivity in human macrophages of HIV-1 was reduced significantly in the presence of AxV. Finally, we show that AxV also blocked the in vitro uptake by macrophages of primary necrotic cells. Similar to apoptotic cells, necrotic cells generated by heat treatment displayed an anti-inflammatory activity. In contrast, mechanical stress-induced necrotic cells led to a decreased secretion of IL-10, indicating a more inflammatory potent-ial. From the experiments presented above, we conclude that AxV influences the clearance of several PS-exposing particles such as viruses, dying, and dead cells.
Acridone-labeled Base-discriminating Fluorescence (BDF) Nucleoside: Synthesis and Their Photophysical Properties
Authors: Saito Yoshio , Hanawa Kazuo , Kawasaki Naomi , Bag Subhendu Sekhar , Saito Isao 
Published: September 2006

Abstract
Acridone-labeled BDF bases AcA and AcU were incorporated into oligonucleotides (ODNs) and their photophysical properties were evaluated. The BDF probe containing AcA is extremely powerful in recognizing opposite base T via enhancement of the fluorescence intensity. Furthermore, they emit strong fluorescence at a longer wavelength than previously reported pyrene-labeled BDF probes and thus can be used for the detection of SNPs.
What is 'continuity of care'?
Authors: Gulliford Martin , Naithani Smriti , Morgan Myfanwy 
Published: September 2006

Continuity of care is concerned with the quality of care over time. There are two important perspectives on this. Traditionally, continuity of care is idealized in the patient's experience of a 'continuous caring relationship' with an identified health care professional. For providers in vertically integrated systems of care, the contrasting ideal is the delivery of a 'seamless service' through integration, coordination and the sharing of information between different providers. As patients' health care needs can now only rarely be met by a single professional, multidimensional models of continuity have had to be developed to accommodate the possibility of achieving both ideals simultaneously. Continuity of care may, therefore, be viewed from the perspective of either patient or provider. Continuity in the experience of care relates conceptually to patients' satisfaction with both the interpersonal aspects of care and the coordination of that care. Experienced continuity may be valued in its own right. In contrast, continuity in the delivery of care cannot be evaluated solely through patients' experiences, and is related to important aspects of services such as 'case-management' and 'multidisciplinary team working'. From a provider perspective, the focus is on new models of service delivery and improved patient outcomes. A full consideration of continuity of care should therefore cover both of these distinct perspectives, exploring how these come together to enhance the patient-centredness of care.
Is self-care a cost-effective use of resources? Evidence from a randomized trial in inflammatory bowel disease
Authors: Richardson Gerald , Sculpher Mark , Kennedy Anne , Nelson Elizabeth , Reeves David , Roberts Chris , Robinson Andrew , Rogers Anne , Thompson David 
Published: September 2006

Objectives: To determine if a whole-system approach to self-management in inflammatory bowel disease (IBD), using a guidebook developed with patients and physicians trained in patient-centred care, leads to cost-effective use of health system resources. Methods: Cost-effectiveness analysis over a one-year time horizon comparing the whole systems self-management approach to treatment with usual treatment. Nineteen hospitals in the northwest England were randomized to the intervention or to be controls; 651 patients (285 at intervention sites and 366 at control sites) with established IBD were included. The economic evaluation related differential health service costs, from a UK NHS perspective, to differences in quality-adjusted life years (QALYs) based on patients' responses to the EQ-5D. Results: The intervention was associated with a mean reduction in costs of £148 per patient and a small mean reduction in QALYs of 0.00022 per patient compared with the control group. This resulted in an incremental cost per QALY gained of £676,417 for treatment as usual and a probability of around 63% that the whole-system approach to self-management is cost-effective, assuming a willingness to pay up to £30,000 for an additional QALY. Conclusions: Although there is uncertainty associated with these estimates, more widespread use of this method in chronic disease management seems likely to reduce health care costs without evidence of adverse effect on patient outcomes.