bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a proprietary mixture of extracts from Sabal serrulata fruits and Urtica dioica roots (WS® 1541) on prostate hyperplasia and inflammation in rats and human cells
Authors: Sens-Albert Carla , Weisenburger Sabrina , König Beatrix C. , Melcher Silas F. , Scheyhing Ulrike A. M. , Rollet Karin , Lluel Philippe , Koch Egon , Lehner Martin D. , Michel Martin C. 
Published: March 2024

Introduction: Phytotherapeutics, particularly extracts from Sabal serrulata (saw palmetto) fruit or Urtica dioica (stinging nettle) root, are popular for the treatment of male lower urinary symptoms in many countries, but their mechanism of action is poorly understood. We performed in vivo and in vitro studies to obtain deeper insight into the mechanism of action of WS® 1541, a proprietary combination of a Sabal serrulata fruit and an Urtica dioica root extract (WS® 1473 and WS® 1031, respectively) and its components.Methods: We used the sulpiride model of benign prostatic hyperplasia in rats and tested three doses of WS® 1541 in comparison to finasteride, evaluating weight of prostate and its individual lobes as well as aspects of inflammation, oxidative stress, growth and hyperplasia. In human BPH-1 cells, we studied the effect of WS® 1473, WS® 1031, WS® 1541 and finasteride on apoptosis, cell cycle progression and migrative capacity of the cells.Results: WS® 1541 did not reduce prostate size in sulpiride treated rats but attenuated the sulpiride-induced changes in expression of most analyzed genes and of oxidized proteins and abrogated the epithelial thickening. In vitro, WS® 1473 and WS® 1031 showed distinct profiles of favorable effects in BPH-1 cells including anti-oxidative, anti-proliferative and pro-apoptotic effects, as well as inhibiting epithelial-mesenchymal-transition.Conclusion: This data supports a beneficial effect of the clinically used WS® 1541 for the treatment of lower urinary tract symptoms associated with mild to moderate benign prostate syndrome and provides a scientific rationale for the combination of its components WS® 1473 and WS® 1031.
Studying daily fluctuations of emotional effort among nurses of intensive care units: the establishment of latent profiles and its relationship with daily secondary traumatic stress and vitality
Authors: Moreno-Jiménez Jennifer E. , Romero Miriam , Blanco-Donoso Luis Manuel , Hernández-Hurtado Mercedes , Garrosa Eva 
Published: March 2024

IntroductionNursing professionals working in Intensive Care Units (ICU) face significant challenges that can result in secondary traumatic stress (STS). These challenges stem from witnessing patients’ suffering and managing difficult tasks (i.e. communication with patients’ relatives). Furthermore, these professionals encounter emotional demands, such as emotional effort, which is the dissonance between the emotion felt and the emotion that should be expressed to meet work expectations. Consequently, we aimed to investigate whether different profiles exist concerning nurses’ levels of emotional effort over a five-day period and whether these profiles are related to daily STS and vitality.MethodsThe sample comprised 44 nursing professionals from ICUs in Spanish hospitals. They were assessed daily, using a package of questionnaires twice per day for five working days: a) immediately after their shift and b) at a later time after working.ResultsThe findings revealed three distinct profiles based on emotional effort levels: high (Profile 1), moderate (Profile 2), and low (Profile 3). These profiles were found to be negative predictors for both daily shattered assumptions and symptomatology.DiscussionThis study underscores the importance of assessing daily emotional demands in an ICU setting. Such assessments are crucial for establishing preventive measures to help nursing professionals manage lower-level emotional demands.
Understanding suicidal ideation disparity between sexual minority and heterosexual Chinese young men: a multiple mediation model of social support sources, self-esteem, and depressive symptoms
Authors: Huang Yiting , Liu Jiayu , Huang Gang , Zhu Dejia , Zhou Yunfei , Hu Jingchu 
Published: March 2024

ObjectivesAlthough sexual minorities have reported higher levels of suicidal ideation than heterosexuals across cultures, the role of various psychosocial factors underlying this disparity among young men has been understudied, particularly in China. This study examined the multiple mediating effects of psychosocial factors between sexual orientation and suicidal ideation in Chinese sexual minority and heterosexual young men.Methods302 Chinese cisgender men who identified as gay or bisexual, and 250 cisgender heterosexual men (n=552, aged 18-39 years) completed an online questionnaire measuring perceived social support, self-esteem, depressive symptoms, and suicidal ideation.ResultsYoung sexual minority men reported significantly higher suicidal ideation and lower social support than their heterosexual peers. Structural equation modelling revealed two multiple indirect pathways. One pathway indicated that sexual orientation was indirectly related to suicidal ideation via family support and depressive symptoms. Another pathway indicated that sexual orientation was indirectly related to suicidal ideation via support from friends, self-esteem, and depressive symptoms.ConclusionsThis study is among the first to examine the potentially cascading relationships between sexual orientation and psychosocial factors with suicidal ideation in a Chinese sample of young men. The findings highlight several promising psychosocial targets (i.e., improving family/friend support and increasing self-esteem) for suicide interventions among sexual minority males in China.
Case report: Environmental adjustment for visual hallucinations in dementia with Lewy bodies based on photo assessment of the living environment
Authors: Ishimaru Daiki , Kanemoto Hideki , Hotta Maki , Nagata Yuma , Koizumi Fuyuki , Satake Yuto , Taomoto Daiki , Ikeda Manabu 
Published: March 2024

BackgroundVisual hallucinations (VH) are associated with visual prediction error in patients with dementia with Lewy bodies (DLB). Given this relationship, environmental adjustments have been suggested, but detailed contents for implementing such environmental adjustments and assessments are poorly documented. This case report preliminarily demonstrates methods for improving VH through our experience with two patients with DLB. We conducted familial interviews to assess the phenomenological features of VH and reviewed photographs of patients’ homes to identify the environmental triggers of VH, known as photo assessment of the living environment (PA-LE).Case descriptionPatient 1 was a 78-year-old woman with a Mini-Mental State Examination (MMSE) score of 11/30. She experienced seeing a stranger, children, and cats at home, which frightened her. VH frequently occurred in the living room and bedroom. The PA-LE showed that several environmental features, such as cushions on a sofa, the pattern on a carpet under a table, and clothing on hangers, were suggestive triggers of VH. Patient 2 was an 88-year-old woman with a MMSE score of 5/30. She had seen strangers, children, and animals at home, some of which were linked to a theft delusion. VH frequently occurred in the living room and bedroom. The PA-LE found that several environmental features, such as clothing on hangers and dolls, were suggestive of VH triggers. Non-pharmacological approaches were tailored to the patients’ environmental and psychological states using interviews and PA-LE. This included removing environmental triggers, reducing negative mood, and providing coping strategies for VH. This improved their VH and their caregivers’ knowledge of VH.ConclusionPhenomenological assessments using photographs of the patient’s home could identify the environmental triggers associated with VH in patients with DLB and assist in environmental adjustments.
Enuresis in young offenders – a study on prevalence and mental health comorbidity
Authors: Koposov Roman A. , Stickley Andrew , Isaksson Johan , Ruchkin Vladislav 
Published: March 2024

BackgroundEnuresis is a common disorder in the school-age period, and is often associated with a variety of behavioral, psychological, and social problems. While early studies suggested an association between enuresis and delinquent behavior, there has been no recent research assessing the prevalence of enuresis and its comorbid psychopathology in young offenders. The aim of this study was to therefore assess the prevalence of enuresis and its associated psychiatric comorbidity in incarcerated young offenders.MethodsThe prevalence of past and current enuresis and comorbid psychopathology was assessed using a semi-structured psychiatric interview and self-reports from 366 incarcerated male young offenders [age 14 to 19 years (mean age = 16.4)] from Northern Russia.ResultsSeventy-three (20.0%) adolescents reported a previous history of enuresis, and in addition almost 10% of the youth reported current enuresis symptoms. Delinquent youth with enuresis did not significantly differ from other youth in the prevalence of comorbid psychiatric diagnoses when assessed by a clinical diagnostic interview, but had significantly higher levels of self-reported mental health problems, and suicidal ideation and attempts.ConclusionProblems with enuresis are common among delinquent youth and may be associated with increased mental health problems. Given the potentially increased risk for suicidal thoughts and behavior in young offenders with enuresis, comprehensive mental health screening of those who are detected with this condition should be considered in the juvenile justice system.
Prevalence and association of HIV and tuberculosis status in older adults in South Africa: an urgent need to escalate the scientific and political attention to aging and health
Authors: Akokuwebe Monica Ewomazino , Osuafor Godswill Nwabuisi , Idemudia Erhabor Sunday 
Published: March 2024

ObjectivesThis study examined the prevalence and sociodemographic factors among older adults with HIV and TB status in South Africa.MethodsThis data was cross-sectional and obtained from the 2019 General Household Surveys in South Africa. Adults 50 years and over with reported HIV and TB status were included (N = 9,180,047). We reported statistical analyses of the descriptive, Chi-square and Fisher’s exact tests, and binary logistic regression.ResultsThe study has found a prevalence rate of HIV to be 5.3% and TB to be 2.9% among older adults aged 50 years and above in South Africa. However, the study found HIV and TB to be highest among older adults residing in Gauteng, KwaZulu-Natal and Eastern Cape provinces. For HIV status, the female gender [AOR = 0.80*, CI 95% = 0.80–0.80] and secondary education [AOR = 0.57, CI 95% = 0.56–0.58] have lower odds of association among older adults with HIV. Regarding TB status, primary education [AOR = 1.08*, CI 95% = 1.06–1.10] and diabetes [AOR = 1.87*, CI 95% = 1.82–1.91] have lower likelihoods of associations among older adults with TB.ConclusionThere is an urgent need to escalate scientific and political attention to address the HIV/TB burden in older adults and, public health policymakers need to take cognizance of the interdependence of inequality, mobility, and behavioural modification among this high-risk population.
Preparing correctional settings for the next pandemic: a modeling study of COVID-19 outbreaks in two high-income countries
Authors: Kwon Jisoo A. , Bretaña Neil A. , Kronfli Nadine , Dussault Camille , Grant Luke , Galouzis Jennifer , Hoey Wendy , Blogg James , Lloyd Andrew R. , Gray Richard T. 
Published: March 2024

IntroductionCorrectional facilities are high-priority settings for coordinated public health responses to the COVID-19 pandemic. These facilities are at high risk of disease transmission due to close contacts between people in prison and with the wider community. People in prison are also vulnerable to severe disease given their high burden of co-morbidities.MethodsWe developed a mathematical model to evaluate the effect of various public health interventions, including vaccination, on the mitigation of COVID-19 outbreaks, applying it to prisons in Australia and Canada.ResultsWe found that, in the absence of any intervention, an outbreak would occur and infect almost 100% of people in prison within 20 days of the index case. However, the rapid rollout of vaccines with other non-pharmaceutical interventions would almost eliminate the risk of an outbreak.DiscussionOur study highlights that high vaccination coverage is required for variants with high transmission probability to completely mitigate the outbreak risk in prisons.
Dense Multi-Scale Graph Convolutional Network for Knee Joint Cartilage Segmentation
Authors: Chadoulos Christos , Tsaopoulos Dimitrios , Symeonidis Andreas , Moustakidis Serafeim , Theocharis John 
Published: March 2024

In this paper, we propose a dense multi-scale adaptive graph convolutional network (DMA-GCN) method for automatic segmentation of the knee joint cartilage from MR images. Under the multi-atlas setting, the suggested approach exhibits several novelties, as described in the following. First, our models integrate both local-level and global-level learning simultaneously. The local learning task aggregates spatial contextual information from aligned spatial neighborhoods of nodes, at multiple scales, while global learning explores pairwise affinities between nodes, located globally at different positions in the image. We propose two different structures of building models, whereby the local and global convolutional units are combined by following an alternating or a sequential manner. Secondly, based on the previous models, we develop the DMA-GCN network, by utilizing a densely connected architecture with residual skip connections. This is a deeper GCN structure, expanded over different block layers, thus being capable of providing more expressive node feature representations. Third, all units pertaining to the overall network are equipped with their individual adaptive graph learning mechanism, which allows the graph structures to be automatically learned during training. The proposed cartilage segmentation method is evaluated on the entire publicly available Osteoarthritis Initiative (OAI) cohort. To this end, we have devised a thorough experimental setup, with the goal of investigating the effect of several factors of our approach on the classification rates. Furthermore, we present exhaustive comparative results, considering traditional existing methods, six deep learning segmentation methods, and seven graph-based convolution methods, including the currently most representative models from this field. The obtained results demonstrate that the DMA-GCN outperforms all competing methods across all evaluation measures, providing DSC=95.71% and DSC=94.02% for the segmentation of femoral and tibial cartilage, respectively.
Immunochemical Recognition of Bothrops rhombeatus Venom by Two Polyvalent Antivenoms
Authors: Sarmiento Karen , Zambrano Jorge , Galvis Carlos , Molina-Olivares Álvaro , Villadiego-Molinares Marisol Margarita , Ramírez-Martínez Johanna Alejandra , Castiblanco Ana Lucía , Aristizabal Fabio A. 
Published: March 2024

The protein profile of Bothrops rhombeatus venom was compared to Bothrops asper and Bothrops atrox, and the effectiveness of antivenoms from the National Institute of Health of Colombia (INS) and Antivipmyn-Tri (AVP-T) of Mexico were analyzed. Protein profiles were studied with sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE) and reverse-phase high-performance liquid chromatography (RP-HPLC). The neutralizing potency and the level of immunochemical recognition of the antivenoms to the venoms were determined using Western blot, affinity chromatography, and enzyme-linked immunosorbent assay (ELISA). Bands of phospholipase A2 (PLA2), metalloproteinases (svMPs) I, II, and III as well as serine proteinases (SPs) in the venom of B. rhombeatus were recognized by SDS-PAGE. With Western blot, both antivenoms showed immunochemical recognition towards PLA2 and svMP. INS showed 94% binding to B. rhombeatus venom and 92% to B. asper while AVP-T showed 90.4% binding to B. rhombeatus venom and 96.6% to B. asper. Both antivenoms showed binding to PLA2 and svMP, with greater specificity of AVP-T towards B. rhombeatus. Antivenom neutralizing capacity was calculated by species and mL of antivenom, finding the following for INS: B. asper 6.6 mgV/mL, B. atrox 5.5 mgV/mL, and B. rhombeatus 1.3 mgV/mL. Meanwhile, for AVP-T, the following neutralizing capacities were found: B. asper 2.7 mgV/mL, B. atrox 2.1 mgV/mL, and B. rhombeatus 1.4 mgV/mL. These results show that both antivenoms presented similarity between calculated neutralizing capacities in our trial, reported in a product summary for the public for the B. asper species; however, this does not apply to the other species tested in this trial.
جماليات فن البورتريه العماني بتقنيتي الاستنسل والشاشة الحريرية لدى طلاب قسم التربية الفنية بجامعة السلطان قابوس
Authors: Al Saadi نجلاء , منجي ياسر , هيبه اسلام , المعمري بدر , الحجري سلمان 
Published: March 2024

يُعَدُّ فن الصور الشخصية (البورتريه) Portrait من أبرز فروع الفنون البصرية الثرية بالإبداعات التعبيرية، ومن أكثرها دلالةً على ملامح الهوية القومية، سواء من خلال تعبيرات الوجوه، أو من خلال ارتباط بعض القَسَمات ذات الصفات العِرقيّة المميزة بالموروث الثقافي والشعبي لتركيبة حضارية معينة، فضلًا عن أنماط الزينة، وطُرُز الأزياء المكملة للبورتريه. وبالإضافة لأثر الاعتبارات السابق ذكرُها في إثراء أفكار فناني البورتريه، ورفدهم بذخيرة بصرية قابلة لمعالجات لا تُحصى، وصياغات قابلة للانفتاح على كافة الاتجاهات والأساليب الفنية، والأداءات التقنية، في مختلف مجالات الفن، فإنها تمثل كذلك مصادر مهمة لإعادة البحث في ملامح الهوية البيئية، والثقافية، والعرقية، بما يرتبط بها من رموز ودلالات. لذا، كان تناول فن البورتريه من هذه الزاوية مبحثًا قابلًا للكشف عن بعض أهم الدوافع التي تؤدي لاستلهام الفنانين موضوعات وأفكار ذات صلة وثيقة بفن الصورة الشخصية، وكذا لتوضيح الكيفيات التي من شأنها أن تتضمن تلك الأعمال في طياتها قِيَمًا تتجاوز المستوى الجمالي الظاهري، إلى مستوىً أعمق يرتبط بمفهوم هوية كإطار عام لكل ثقافة ذات خصوصية. ويركز هذا البحث بصفةٍ أساسية على أعمال الصورة الشخصية المنفذة عن طريق بعض وسائط فن الحفر والطباعة (الجرافيك) Printmaking؛ إذ يهدف إلى مُقاربة بعض أبرز الخصائص الجمالية لفن الصورة الشخصية المعاصر في سلطنة عُمان – والذي يستعمل الباحثون تعبير (البورتريه العماني) للإشارة لها في البحث – وذلك من خلال تحليل مجموعة من الأعمال الفنية الطباعية، التي أنتجها عددٌ من طلاب قسم التربية الفنية بجامعة السلطان قابوس، في مقرر الحفر (الجرافيك).
Programa “DGΤul”: habilidades del aprendizaje del idioma inglés en estudiantes de Educación Superior
Authors: Valera Yataco Patricia , Camasca Macedo Charles Dummar , Valera Yataco Jessica del Pilar , Lescano López Galia Susana 
Published: March 2024

La incorporación de las nuevas tecnologías en la enseñanza se ha convertido en una excelente vía para integrar procesos altamente demandados por la sociedad contemporánea, y para que los involucrados posean habilidades en el logro de tales fines. El objetivo de la investigación fue determinar la influencia de la aplicación del programa “DGTul” sobre habilidades del aprendizaje del idioma inglés en estudiantes de un instituto de Educación Superior de Lima, Perú. Se aplicó un enfoque cuantitativo de nivel explicativo basado en el método hipotético deductivo con un diseño cuasi experimental. Los resultados demostraron que al aplicar el programa “DGTul” al grupo experimental influyó sobre las habilidades del aprendizaje del idioma inglés frente al grupo control, a quienes no se le aplicó el programa. El uso del programa “DGTul” logró una mejora significativa en las habilidades de aprendizaje del inglés en los estudiantes del instituto superior. Esta herramienta abre las puertas para el propio docente logre reinventarse con las nuevas estrategias de enseñanza, y representa, a grandes rasgos, una importante ventaja ya que son programas que pueden hallarse de forma libre generando economía en los involucrados.
فعل الترجمة بین المرامزة والتأویل
Authors: اعرجي فاطمة 
Published: March 2024

إنّ أهم ركائز قراءة النص والذي یحرّك عنصر القراءة هو "اللاتحدید". اللاتحدید هو العنصر الذي ركّز علیه رواد نظریة التلقي في رهانات بناء المعنی علی أساس الاختلاف والتنوع. وإنّ التنوع هو الذي یحمل المتلقي علی رد الفعل، وذلك في إطار تواصلي تفاعلي بین الأنا الباثة والأنا المتلقیة. إنّ الترجمة من هذا المنظور هي تفكیك وبناء، ونحن نفكك النص ونبنیه من جدید حین نروم فهمه، ونصوغه صیاغة فنیة أخری، علی أنّ الترجمة ممارسة تواصلیة في الدرجة الأولی لانتماءها القوي إلی السیاق الثقافي.
هناك رؤیتین للترجمة، وهما الترجمة الحرفیة والترجمة التأویلیة، الترجمة التأویلیة تدعو إلی الاستئناس مع القارئ، والترجمة الحرفیة تدعو إلی الأمانة، حتی وإن أدّت هذه الأمانة إلی استغراب القارئ. فربما الترجمة التأویلیة هي التي تولد فیها التعددیات، وإنها القراءة التي تحثّ علی الانفتاح وتكثر المدلول. ومن هذا المنظور، الترجمة التأویلیة هي المسؤولة عن التعددیة والاختلاف بالدرجة الأولی، حیث لا یوجد أصل مطلق للمعنی وأن الترجمة هي بنفسها، ذلك "الاختلاف" الذي یفتح ظهور الدلالات.
بناءً علی نظریة "أصالة المختلف"، سعینا في دراستنا هذه إلی البحث عن الاستراتیجیات والأسالیب النّاجعة في ترجمة عناوین الروایات العربیة إلی الفارسیة، وذلك في ضوء استراتیجیتي المرامزة والتأویل. ورأینا من خلال النماذج التي انتخبناها من ضمن أخری، أنّ الترجمة التأویلیة لا تبحث عن المكافئ المعجمي، بل عما یُسمّی"المكافئ الخطابي"، فنحن لا نترجم اللغة بل نترجم الخطاب. ووفق مبدأ الاختلاف لاحظنا أنّ الترجمة متبوعة بعناصر التلقي، لیس بإمكان المترجم أن یسیطر علیها كلها. فلاحظنا بأن یجب علی الترجمة أن تسمح بالتنوع الثقافي
التحليل المكاني للأنشطة التجارية الترفيهية في بلدية المنصور ( حي المتنبي)
Authors: احمد اريج بهجت 
Published: March 2024

المستخلص :-
ان من اهم ما يريح الانسان هو الترويح عن النفس وهو ما يحصل عليه بالترفيه منذ القدم، فسعى دائما لتطوير ابسط الخدمات والأنشطة لتصل الى مرحله التطور التي هي عليه الان بما تسمى بالخدمات التجارية الترفيهية للتمتع بخدمه الترفيه والشراب والطعام في آن واحد، وتأتي أهمية الدراسة من الصلة المباشرة بين الانشطة التجارية الترفيهية وراحة الانسان اذ تؤدي هذه الأنشطة الى تخفيف ضغوطات الحياة فضلا عن توفير العديد من احتياجات سكان المدن من المأكولات والمشروبات، لذا فان دراستها ومعرفة مدى كفاءة أدائها الوظيفي تعد هدفا مهما للدراسة ، ومن هنا جاءت اهم مشكلات الدراسة وهي التباين المكاني للتوزيع الجغرافي للأنشطة التجارية الترفيهية وتباين أدائها الوظيفي ومستوى كفاءتها، اما الإجراءات التي استخدمها الدراسة للإجابة على اهم تساؤلات الدراسة جاءت من خلال الدراسة الميدانية واستخدام استمارة استبيان لعينة مكونة من (1439) استمارة وزعت على مرتادين الأنشطة التجارية الترفيهية ، ومن اهم ما توصلت له الدراسة انتشار الأنشطة التجارية الترفيهية وتوسعها في مدينه بغداد خاصة مناطقها وشوارعها التجارية ومنها شوارع حي المتنبي التي شهدت تطوراً في تلك الانشطة وبلغ عددها (34) نشاطاً موزعاً على جانبي شوارعها التجارية يرتادها (158230) شخصاً / اسبوع وبمعدل (٢٢٦٠٤) شخصاً / يوم من مختلف مناطق محافظه بغداد واقضيتها وبنسبة قليله من المحافظات القريبة منها لما لهذا الحي من أهمية كبيرة اكتسبها من تواجد تلك الأنشطة على جانبي شوارعه التجارية ،خاصة مع تقديمها لأفضل الخدمات وبأسعار مناسبه نوعا ما ،ما يتطلب ايجاد افضل السبل لتطويرها ومحاوله التغلب على المشكلات التي يواجها السكان عند وصولهم لتلك المراكز بهدف الحصول على خدمه تجاريه ترفيهيه متكاملة ،وتنوع وتركز الأنشطة على جانبي الشوارع التجارية في حي المتنبي أدى الى ارتفاع اعداد المرتادين لهذه المراكز بسبب تميز الخدمات التي تقدمها ولكن ارتفاع اعداد المرتادين أدى الى ظهور العديد من المشكلات التي حاولت الدراسة القاء الضوء عليها ووضع العديد من الحلول لها.