bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous Curvature Induction in an Artificial Bilayer Membrane
Authors: Elizebath Drishya , Vedhanarayanan Balaraman , Dhiman Angat , Mishra Rakesh K. , Ramachandran C. N. , Lin Tsung‐Wu , Praveen Vakayil K. 
Published: March 2024

AbstractMaintaining lipid asymmetry across membrane leaflets is critical for functions like vesicular traffic and organelle homeostasis. However, a lack of molecular‐level understanding of the mechanisms underlying membrane fission and fusion processes in synthetic systems precludes their development as artificial analogs. Here, we report asymmetry induction of a bilayer membrane formed by an extended π‐conjugated molecule with oxyalkylene side chains bearing terminal tertiary amine moieties (BA1) in water. Autogenous protonation of the tertiary amines in the periphery of the bilayer by water induces anisotropic curvature, resulting in membrane fission to form vesicles and can be monitored using time‐dependent spectroscopy and microscopy. Interestingly, upon loss of the induced asymmetry by extensive protonation using an organic acid restored bilayer membrane. The mechanism leading to the compositional asymmetry in the leaflet and curvature induction in the membrane is validated by density functional theory (DFT) calculations. Studies extended to control molecules having changes in hydrophilic (BA2) and hydrophobic (BA3) segments provide insight into the delicate nature of molecular scale interactions in the dynamic transformation of supramolecular structures. The synergic effect of hydrophobic interaction and the hydrated state of BA1 aggregates provide dynamicity and unusual stability. Our study unveils mechanistic insight into the dynamic transformation of bilayer membranes into vesicles.
Efficient Selective Catalytic Fixation of CO2 into Epoxide to Form Cyclic Carbonates Using Sodium Aluminate Engineered Gamma Alumina Catalyst
Authors: Dhanusha Rajanna , Srinivasappa Puneethkumar M. , Alla Sarat Chandra , Hemavathi Manjunath , Prasad Divya , Chaudhari Nitin K. , Jadhav Arvind H. 
Published: March 2024

The anthropogenic carbon dioxide (CO2) fixation and various engineering strategies are gaining very significant attention because of the expansion of the net‐zero carbon environment in the atmosphere. Herein, we designed a sodium aluminate@γ‐alumina (NaAlO2@γ‐Al2O3) catalyst by a simple and facile precipitation and impregnation tactics. A series of different weight percentage NaAlO2@γ‐Al2O3 materials were successfully synthesized and well characterized by using advanced analytical and spectroscopic techniques such as TGA, XRD, FE‐SEM, TEM/HR‐TEM, FT‐IR, Raman, TPD, and XPS analysis. The NaAlO2@γ‐Al2O3 catalyst was employed as a competent catalyst for the CO2 fixation under atmospheric pressure reaction conditions. The catalytic activity results evidently revealed that the cycloaddition reaction successfully achieved 94% styrene oxide conversion and 93% selectivity, along with an 87% yield of the styrene carbonate at 120 °C for 6 h. Furthermore, we comprehensively examined the effect of different reaction parameters such as the effect of sodium aluminate amount, co‐catalyst amount, temperature, and time for CO2 fixation reaction. Additionally, different terminal and internal epoxides were tested under optimized reaction conditions and achieved moderate to excellent yield of the desired cyclic carbonate products. Interestingly, a plausible reaction mechanism was proposed for the styrene carbonate synthesis using NaAlO2@γ‐Al2O3 catalyst surface with the support of characterization and experimental results. Remarkably, the NaAlO2@γ‐Al2O3 catalyst could be easily recoverable and successfully recyclable up to six consecutive cycles without declining its initial catalytic activity along with stable structural and physicochemical properties.
Can intensive trapping to reduce the abundance of an invasive crayfish benefit an imperiled congener?
Authors: Reisinger Lindsey , Tripp Nicole , Atchia Alison , Bolds Sara , Cook David , Fralick Kasey , Ganas Danielle , Hayman Blair 
Published: March 2024

Abstract
Management aimed at reducing the population sizes of established invasive species can be beneficial for the conservation of native species. Crayfish are some of the most widespread and impactful invasive species in freshwater ecosystems.
This study evaluated the efficacy of intensive baited trapping as a tool to reduce the abundance of an invasive crayfish (Procambarus spiculifer) in small streams and benefit an imperiled congener (Procambarus pictus). The invasive crayfish was captured and removed from a 1‐km stream reach through three rounds of intensive trapping conducted over a 16‐month period.
The abundance of the invasive species declined significantly in the trapping reach after the initial round of trapping. Throughout the year following the onset of trapping, its abundance within the trapping reach was less than half of that at control sites. The sex ratio of invasive crayfish collected in traps was approximately 1:1, and 31% of captured individuals were likely to be immature based on size class. The abundance of the imperiled species did not change significantly over the study period, but 1 year may not be long enough to detect a response.
Overall, the data suggest that periodic intensive trapping can effectively reduce the abundance of this invasive crayfish in small streams, and the extent to which this benefits the imperiled species remains an open question. Future research examining how trapping can best be applied to achieve lasting effects (including trap type, season and barriers to immigration) would be valuable for understanding the conservation potential of this management technique.
Construction and analysis of a joint diagnostic model of machine learning for cryptorchidism based on single‐cell sequencing
Authors: Chen Yuehua , Zhou Xiaomeng , Ji Linghua , Zhao Jun , Xian Hua , Xu Yunzhao , Wang Ziheng , Ge Wenliang 
Published: March 2024

AbstractBackgroundCryptorchidism is a condition in which one or both of a baby's testicles do not fully descend into the bottom of the scrotum. Newborns with cryptorchidism are at increased risk of developing infertility later in life. The aim of this study was to develop a novel diagnostic model for cryptorchidism and to identify new biomarkers associated with cryptorchidism.MethodsThe study data were obtained from RNA sequencing data of cryptorchid patients from Nantong University Hospital and the Gene Expression Omnibus (GEO) database. Differential expression analysis was used to obtain differentially expressed genes (DEGs) between the control and cryptorchid groups. These DEGs were analyzed for their functions by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment using GSEA software. Random Forest algorithm was used to screen central genes based on these DEGs. Neuralnet software package was used to develop artificial neural network models. Based on clinical data, receiver operating characteristic (ROC) was used to validate the models. Single‐cell sequencing analysis was used for the pathogenesis of cryptorchidism.ResultsWe obtained a total of 525 important DEGs related to cryptorchidism, which are mainly associated with biological functions such as supramolecular complexes and microtubule cytoskeleton. Random forest approach screening obtained eight hub genes. A neural network based on the hub genes showed a 100% success rate of the model. Finally, single‐cell sequencing analysis validated the hub genes.ConclusionWe developed a novel diagnostic model for cryptorchidism using artificial neural networks and validated its utility as an effective diagnostic tool.
Stigma in marketing and consumer research: A literature review and research agenda
Authors: Rocha Rodolfo Rodrigues , Veloso Andres Rodriguez 
Published: March 2024

AbstractStigma is a discrediting attribute that emerges in social interactions, playing different roles in different contexts. Several fields (e.g., sociology and psychology) have dedicated special attention to this phenomenon as it significantly impacts people's lives. Although there is some interest in the idiosyncrasies of stigma in marketing and consumer behavior, the literature investigating such a concept is still fragmented. This systematic literature review addresses the stigma concept in marketing and consumer behavior studies by analyzing 82 articles directly approaching stigma in empirical studies. As to the contributions of our study: (1) it synthesizes the literature on stigma in marketing and consumer research, presenting the state‐of‐the‐art in this domain; (2) our two‐step thematic analyses combine a descriptive assessment of our sample by using consolidated models from socio‐psychology and an examination of the articles from the perspective of the dynamic nature of stigma in the marketplace and the processes of stigmatization and destigmatization; (3) it put forward a future research agenda suggesting research avenues worth exploring by marketing and consumer behavior researchers to advance knowledge on marketplace stigma. We found that stigma is a topic that fits in a wide range of theories, contexts, and methods in marketing and consumer behavior literature.
Antioxidant and Antimicrobial Potential of 1,8‐Naphthyridine Based Scaffolds: Design, Synthesis and in Silico Simulation Studies within Topoisomerase II
Authors: Elkanzi Nadia A. A. , Hrichi Hajer , Muqbil Alsirhani Alaa , Bakr Rania B. 
Published: March 2024

AbstractA series of spiro β‐Lactams (4 a–c, 7 a–c) and thiazolidinones (5 a–c, 8 a–c) possessing 1,8‐naphthyridine moiety were synthesized in this study. The structure of the newly synthesized compounds has been confirmed by IR, 1H‐NMR, 13C NMR, mass spectra, and elemental analysis. The synthesized compounds were tested in vitro for their antibacterial and antifungal activity against various strains. The antimicrobial data showed that most of the compounds displayed good efficacy against both bacteria and fungi. The structure‐activity relationship (SAR) studies suggested that the presence of electron‐withdrawing chloro (3 b, 4 b, and 5 b) and nitro groups (7 b, 8 b) at the para position of the phenyl ring improved the antimicrobial activity of the compounds. The free radical scavenging assay showed that all the synthesized compounds exhibited significant antioxidant activity on DPPH. Compounds 8 b (IC50=17.68±0.76 μg/mL) and 4 c (IC50=18.53±0.52 μg/mL) showed the highest antioxidant activity compared to ascorbic acid (IC50=15.16±0.43 μg/mL). Molecular docking studies were also conducted to support the antimicrobial and SAR results.
Cells in the liver microenvironment regulate the process of liver metastasis
Authors: Wang Pei , Jie Yu , Yao Lin , Sun Yi‐meng , Jiang Da‐peng , Zhang Shi‐qi , Wang Xiao‐yan , Fan Yu 
Published: March 2024

AbstractThe research of liver metastasis is a developing field. The ability of tumor cells to invade the liver depends on the complicated interactions between metastatic cells and local subpopulations in the liver (including Kupffer cells, hepatic stellate cells, liver sinusoidal endothelial cells, and immune‐related cells). These interactions are mainly mediated by intercellular adhesion and the release of cytokines. Cell populations in the liver microenvironment can play a dual role in the progression of liver metastasis through different mechanisms. At the same time, we can see the participation of liver parenchymal cells and nonparenchymal cells in the process of liver metastasis of different tumors. Therefore, the purpose of this article is to summarize the relationship between cellular components of liver microenvironment and metastasis and emphasize the importance of different cells in the occurrence or potential regression of liver metastasis.
Rituximab‐induced psoriasis in a patient with pemphigus vulgaris: A case report and literature review
Authors: Ghadirzade Arani Leila , Moslemi Haghighi Shima , Nasiri Soheila , Dadkhahfar Sahar 
Published: March 2024

Key Clinical MessageRituximab which is established as a main treatment for pemphigus vulgaris can be a potential causative factor for development of psoriasis in some patients. It is preferred to avoid using rituximab in patients who had a history of psoriasis. Acquainting medical doctors about rituximab‐related cutaneous complications will help them in detection and management.AbstractRituximab is a human/murine monoclonal antibody targeting the CD20 antigen on B‐lymphocytes surface. Although it is used as promising treatment for pemphigus, nowadays it is also a new therapy for other autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis, and others like non‐Hodgkin's lymphoma. Although there is increasing evidence regarding the safety and effectiveness of rituximab in these diseases, many cutaneous adverse effects have been reported. Here, we describe a 48‐years‐old patient affected with pemphigus vulgaris who developed psoriatic lesions on her on scalp, trunk, and extremities, 4 months after the second course of rituximab.
Peritoneal tuberculosis masquerading as an ovarian malignancy in a young female: A case report
Authors: Oppong Bright , Gyabaah Solomon , Amponsah Gorden Manu , Quansah Ato , Darkwa Eric Amoako 
Published: March 2024

AbstractThe clinical manifestations of peritoneal tuberculosis are quite variable, nonspecific and mimic many diseases and pathological conditions such as lymphoma, and ovarian malignancy. Due to this clinical overlap and limited accuracy of diagnostic tests, more awareness of this disease is required to enable early diagnosis and prompt treatment. This is a case of a 25‐year‐old female with no known chronic illness who presented with worsening generalized abdominal pains and distension of 2 months duration. There was an associated significant weight loss of 17 kg. She was initially diagnosed with ovarian malignancy based of ultrasound findings and elevated CA‐125 levels. However, further evaluation later was consistent with peritoneal tuberculosis for which she was treated. Her symptoms resolved completely after 6 months of anti‐tuberculosis treatment. Diagnosis of abdominal TB remains challenging as it is non‐specific. Its features and clinical manifestation overlap with other conditions such as ovarian malignancy. A high index of suspicions and judicious application of the available diagnostic test is need for prompt diagnosis. No single test can effectively diagnose peritoneal TB, but a combination of history, and radiological, immunologic, molecular, and cytologic tests are important.
Hair removal laser‐induced Fox–Fordyce disease emerging on the axillary and pubic areas: Report of a case and review of literature
Authors: Sepaskhah Mozhdeh , Hamedpour Rahil , Sari Aslani Fatemeh 
Published: March 2024

Key Clinical MessageFox–Fordyce disease is a recognized adverse effect of depilating lasers. It should be considered among the differential diagnoses of the pruritic perifollicular papules that occur at the hair removal laser treatment site, including Alex/Diode laser.AbstractFox–Fordyce disease (FFD) is an uncommon skin disorder affecting the apocrine sweat glands and presents as pruritic skin‐colored papules, mainly on the axillary and pubic areas. Some predisposing factors are proposed, including hormonal changes. A few cases of FFD have been reported after hair removal by light‐ and laser‐assisted devices. Herein, we report FFD in some areas (axillary and pubic areas) treated with Alex/Diode hair removal laser.
Initial spinal epidural hematoma symptoms mimic artery dissection
Authors: Yabuki Shunya , Hirai Hiroyuki , Miyajima Masayuki , Moro Takatomo 
Published: March 2024

Key Clinical MessageAn elderly patient with upper back pain and hypertension was diagnosed as having spontaneous spinal epidural hematoma (SSEH) after excluding artery dissection. The initial symptoms of SSEH mimic those of artery dissection, and the symptoms of spinal damage frequently appear later. Physicians should, therefore, be mindful of SSEH.
Transhepatic approach of patent foramen ovale closure in the setting of congenital inferior vena cava anomaly
Authors: Soodi Deepa , Nwaedozie Somto , Shah Milind , Girotra Sudhakar 
Published: March 2024

Key Clinical MessagePatent foramen ovale (PFO) is the most common interatrial septal abnormality. The indications for PFO device closure are still being evaluated, with the most common reason being to prevent cerebrovascular accidents (CVA) caused by paradoxical embolism of deep vein thrombosis (DVT) in the lower extremities. This procedure is usually performed through percutaneous intervention using femoral vein access. Here, we present a case of PFO closure using a transhepatic approach, as femoral vein access was not feasible due to an interrupted inferior vena cava (IVC). The patient had a prominent left‐sided IVC, larger than the right‐sided IVC, and the left‐sided IVC served as the main draining conduit via the hemiazygous system, which then connected to the azygous vein and emptied into the right atrium (RA). Cardiac MRI confirmed these findings, including the continuation of the suprahepatic IVC to the right atrium. With the assistance of interventional radiologist, transhepatic access was achieved, and the PFO was successfully closed. Hemostasis was achieved using coil embolization, and there were no post‐procedural complications.
Distal penile pyogenic granuloma: A case report
Authors: Mwasakyalo Gideon Safiel , Bright Frank , Mbwambo Orgenes Jasper , Ngowi Bartholomeo Nicholaus , Mwakibibi Daniel , Mbwambo Jasper Saidi , Majura Musa Raymond , Sanga Evans Azina , Mremi Alex 
Published: March 2024

Key Clinical MessageThe mainstays of treatment for granuloma pyogenicum include careful evaluation of any penile growth, thorough excision of the polypoid, histological examination, and close monitoring to check relapse and management.AbstractPyogenic granuloma is an acquired noncancerous vascular proliferation that arises from the mucosa and skin, seldom subcutaneously or intravascularly. It is also referred to as telangiectasis granuloma or lobular capillary haemangioma. The risk factors include vascular abnormalities, medicines, hormones, and microtrauma. We discussed the case of a 24‐year‐old man who had a poorly managed ventral distal penile polypoid lesion at a peripheral hospital. Upon further histopathological examination, the diagnosis of pyogenic granuloma was made. Histopathologically speaking, the term “pyogenic granuloma” is misleading because the illness is not linked to the production of granulomas. Pyogenic granuloma's etiopathogenesis is still unknown; true hemangioma is thought to be a reactive hyperproliferative of the vasculature brought on by a variety of stimuli; pyogenic granuloma may be caused by uneven angiogenic factor production in response to minor local trauma or cutaneous disease. Histopathological analysis and surgical excision are the methods used for diagnosis and treatment. The mainstay of treatment for granuloma pyogenic granuloma includes careful evaluation of any penile growth, thorough excision of the polypoid, histological examination, close follow‐up to check for relapse, and early management.
Effect of cation addition on silica scale on glass surfaces
Authors: Hayashi Shogo , Hatano Shota , Kobayashi Tomoki , Saito Noritaka , Nakashima Kunihiko 
Published: March 2024

AbstractMineral components in tap water generally contaminate sanitary ware. In this study, various cations (Mg, Ca, and Al) were added to an aqueous solution containing silica to prevent water stains on sanitary ware. The particle size in the aqueous solution was measured and observed to increase for all cations. To create artificial water stains, a solution containing the cations and silica was dropped onto glass and allowed to dry. When these water stains were removed by sliding, the removal rate was higher for the water stains that contained the cations. This trend was attributed to the formation of precipitates owing to the reaction of silica with the added cations in the aqueous solution. The formation of these precipitates possibly increased the particle size and brittleness of water stains owing to their sparse structure. These findings provide insights into silica‐scale removal, which can improve the cleanliness of sanitary ware and reduce the frequency of maintenance.
On the Specificity of Nanozymes: A Perspective
Authors: Wei Gen , Liu Shujie , Peng Yung‐Kang , Wei Hui 
Published: March 2024

Comprehensive SummaryWe have compiled eight promising strategies for enhancing the specificity and selectivity of nanozymes, as depicted in the comprehensive summary above. Enzymes exhibit intricate and sophisticated structures, including substrate channels and active sites, which can inform the design of nanozymes. Replication of these structural features and the application of facet engineering/doping techniques can significantly enhance the catalytic specificity of nanozymes. Alternatively, the use of Molecularly Imprinted Polymers (MIPs) to coat nanozymes represents an effective approach to impart substrate specificity. Furthermore, several straightforward stopgap strategies have been devised to improve nanozyme specificity for analytical applications, such as the integration of biorecognition elements and nanozyme sensor arrays through surface modification.imageKey Scientistsimage
Targeted Redox Balancing through Pulmonary Nanomedicine Delivery Reverses Oxidative Stress Induced Lung Inflammation
Authors: Ghosh Ria , Das Monojit , Mondal Susmita , Banerjee Amrita , Roy Lopamudra , Das Anjan Kumar , Pal Debasish , Bhattacharya Siddhartha Sankar , Bhattacharyya Maitree , Pal Samir Kumar 
Published: March 2024

AbstractNon‐invasive delivery of drugs is important for the reversal of respiratory diseases essentially by‐passing metabolic pathways and targeting large surface area of drug absorption. Here, we study the inhalation of a redox nano medicine namely citrate functionalized Mn3O4 (C−Mn3O4) duly encapsulated in droplet evaporated aerosols for the balancing of oxidative stress generated by the exposure of Chromium (VI) ion, a potential lung carcinogenic agent. Our optical spectroscopic in‐vitro experiments demonstrates the efficacy of redox balancing of the encapsulated nanoparticles (NP) for the maintenance of a homeostatic condition. The formation of Cr‐NP complex as an excretion of the heavy metal is also demonstrated through optical spectroscopic and high resolution transmission optical microscopy (HRTEM). Our studies confirm the oxidative stress mitigation activity of the Cr‐NP complex. A detailed immunological assay followed by histopathological studies and assessment of mitochondrial parameters in pre‐clinical mice model with chromium (Cr) induced lung inflammation establishes the mechanism of drug action to be redox‐buffering. Thus, localised delivery of C−Mn3O4 NPs in the respiratory tract via aerosols can act as an effective nanotherapeutic agent against oxidative stress induced lung inflammation.
Strain Engineering for Electrocatalytic Overall Water Splitting
Authors: Guo Wenxin , Chai Dong‐Feng , Li Jinlong , Yang Xue , Fu Shanshan , Sui Guozhe , Zhuang Yan , Guo Dongxuan 
Published: March 2024

AbstractStrain engineering is a novel method that can achieve superior performance for different applications. The lattice strain can affect the performance of electrochemical catalysts by changing the binding energy between the surface‐active sites and intermediates and can be affected by the thickness, surface defects and composition of the materials. In this review, we summarized the basic principle, characterization method, introduction strategy and application direction of lattice strain. The reactions on hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) are focused. Finally, the present challenges are summarized, and suggestions for the future development of lattice strain in electrocatalytic overall water splitting are put forward.