bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studi Literasi Tentang Frekuensi Langkah Dan Panjang Langkah Pada Kecepatan Lari Sprint 100 Meter
Authors: Soemaredjo Bambang sujiono 
Published: March 2024

Penelitian bertujuan untuk mengetahui frekuensi langkah dan panjang langkah terhadap kecepatan lari sprint 100 meter pada atlet-atlet top dunia. Penelitian ini secara keseluruhan dilakukan melalui studi literatur dengan data-data yang ada di artikel serta informasi di media social. Penelitian ini mengggunakan sampling atlet-atlet putera dan puteri yang telah menjuarai dibeberapa kejuaraan atletik dunia. Disain Penelitian ini menggunakan metode analisis dokumenter pada data-data yang ada di media olahraga dan juga artikel berupa profil dari atlet putera dan puteri yang telah menjuarai beberapa kejuaraan dunia atletik. Hasil dari penelitian ini didapatkan : 1). Frekuensi langkah merupakan faktor yang memberikan kontribusi lebih besar terhadap kecepatan lari Sprint dibandingkan dengan panjang langkah,2). Sprinter dengan Tinggi Badan dibawah 180 cm memiliki kecepatan lari yang lebih baik dibandingkan dengan Sprinter dengan Tinggi Badan diatas 180 cm,3). Sprinter dengan Tinggi Badan diatas 180 cm jumlahnya lebih banyak dibandingan dengan Sprinter dengan Tinggi Badan dibawah 180 cm.

Kata kunci: Frekuensi Langkah, Panjang Langkah, Lari Sprint 100 meter.

ABSTRACT
The study aims to find out the frequency of steps and the length of steps against the 100-meter sprint speed in the world's top athletes.This research was conducted in its entirety through literature studies with the data in the article as well as information on social media.This study uses sampling of male and female athletes who have won in several world athletics championships.This research design uses documentary analysis method on data in sports media and also articles in the form of profiles of male and female athletes who have won several athletics world championships.The results of this study were obtained: 1). Step frequency is a factor that contributes more to Sprint running speed compared to the length of the step,2).Sprinters under 180 cm have a better running speed compared to sprinters with a height above 180 cm,3).Sprinters with height above 180 cm are more numerous than sprinters with heights below 180 cm.

Keywords: Step Frequency, Step Length, Sprint Speed 100 Meters
Osteoporosis management in a rural community hospital in Japan: A cross-sectional study
Authors: Mabuchi Sayaka , Ohta Ryuichi , Sano Chiaki 
Published: March 2024

Abstract
Objectives: Osteoporosis is a condition characterized by decreased bone strength and an increased risk of fragility fractures. Its prevalence is increasing in developed countries, highlighting the need for appropriate diagnosis and intervention. However, in practice, adequate testing and treatment are not often provided. Therefore, in this study, we investigated the status of osteoporosis management in a rural community hospital in Japan.
Design: Cross-sectional.
Setting: Department of General Medicine from a rural community hospital, Japan.
Participants: A total of 984 women aged ≥65 years who were recommended to undergo osteoporosis screening.
Primary and secondary outcome measures: Bone mineral density (BMD) testing rate and characteristics of patients who underwent these tests, including diagnosis and treatment rates for osteoporosis.
Results: The BMD testing rate was 14%. Despite being at risk of osteoporosis, older patients and those requiring nursing care showed a lower rate of testing. The proportion of patients diagnosed withosteoporosis was 41%, and the treatment rate was 19%.
Conclusions: The management of osteoporosis in a rural Japanese community hospital was found to be inadequate. The rate of BMD testing was low, particularly among older adults and those requiring nursing care. This finding suggests that these patients may be considered to have osteoporosis without confirming the diagnosis through testing based on their age alone, raising the question of ageism and highlighting the importance of personalized healthcare that is not based solely on age. Further cohort studies and intervention strategies are required to fully investigate these issues.
Health-Related Quality of Life Questionnaire for Corneal Anesthesia Patients: A Content Validity Assessment
Authors: Dimaras Helen , Khan Farheen , Noronha Roxanne , Williams Sara , Satgunalingam Anojan , Wong-Riff Karen , Ali Asim 
Published: March 2024

Abstract

Background/Objectives: FACE-Q Craniofacial Module (FACE-Q) is a validated patient-reported outcome measure (PROM) for appearance. This study aimed to assess the content validity of FACE-Q for use in patients treated for corneal anesthesia. Subjects/Methods: This was a prospective observational and qualitative study. Cognitive debriefing interviews were conducted with patients ≥ 8 years old who had surgical treatment for corneal anesthesia at least six months before time of study. Interviews consisted of gathering feedback on the comprehensibility, comprehensiveness, and relevance of three eye scales and checklists and four health-related quality-of-life scales. Based on the input from participants and further discussion with ophthalmologists, scientists, and patient advocates, the scales and checklists were modified, then further refined with input from additional participants. Results Feedback on the FACE-Q scales and checklists was obtained from 10 participants. Instructions for the scales were modified to enhance comprehensibility. Eleven items were revised for enhanced comprehensibility and relevance. Twelve items were added to enhance comprehensiveness. Four items were removed due to their irrelevance to corneal anesthesia. Modifications to the eye and health-related quality-of-life scales were generally condition-specific and generic respectively. A comment section was added to the end of each scale and checklist. Conclusions FACE-Q may be a suitable PROM to adapt to measure appearance-based outcomes in corneal anesthesia patients. With lived expertise, clinical, and scientific input, the content validity of FACE-Q was improved for use in corneal anesthesia patients. The modified FACE-Q is now ready for psychometric evaluation and further validation.
Evaluation of state early childhood education licensing policies with recommended sanitation and hygiene related practices: A multi-state policy evaluation
Authors: Besrat Bethlehem N. , Lynch Claire Burns , Marshall Janese , Garcia-Williams Amanda G. , Esschert Kayla Vanden , Rutt Candace 
Published: March 2024

Abstract

Objective: Each year, an estimated 12.5 million children under age 5 utilize early childhood education (ECE) facilities. States have developed licensing regulations to ensure the safe operation of facilities, including requirements related to sanitation and hygiene practices. This study aimed to evaluate sanitation- and hygiene-related practices included in ECE regulations to assess their alignment with best practices outlined in Caring for Our Children National Health and Safety Performance Standards (CFOC).
Methods: CFOC standards were reviewed, and 42 sanitation- and hygiene-related practices were identified. These recommended practices fell into five categories: toileting, diapering, cleaning, hand hygiene, and general hygiene. State regulations for all 50 US states were compared with recommended best practices from CFOC. Using a standardized codebook, two coders independently reviewed each state regulation and assessed how well it aligned with recommended best practices from CFOC using a 4-point Likert Scale (1 – Not addressed, 2 – Somewhat addressed, 3 – Mostly addressed, 4 – Fully addressed).
Results: Across all sanitation and hygiene standards evaluated, 64% of standards were scored somewhat, mostly, or fully addressed in state ECE regulations, with 7% of standards scored as fully addressed. Standards in the diapering, toileting, and cleaning category were scored somewhat, mostly, or fully addressed more often compared to standards in the general hygiene and hand hygiene category.
Conclusions: Few state ECE regulations fully addressed recommended sanitation and hygiene practices. As state regulations are updated, future studies can compare and evaluate licensing regulations alignment to recommended best practices for safe and hygienic operation of facilities.
Metabolomics combined with transcriptomics reveals the accumulation mechanism of the fruit pulp colour of Baccaurea ramiflora Lour
Authors: Huang Jianjian , Chen Jie , Zhu Hui , Zheng Yuzhong , Zheng Jiaqi , Wen Xueying , Cai Suying , Zhu Yingchun , Wu Qinghan , Chen Zikai , Wu Fengnian 
Published: March 2024

Abstract

Baccaurea ramiflora Lour., a wild fruit tree with edible, ornamental, and medicinal qualities. The mechanism behind the color accumulation in its fruit pulp, which can be either pink or milky-white, remains unclear. This study investigates the metabolome and transcriptome of two B. ramiflora pulp types—LR (milky-white at maturity) and BR (pink at maturity)—to elucidate their coloration processes. We identified 35 flavonoids, including nine involved in the anthocyanin synthesis pathway, confirming cyanidin as the pivotal pigment for the pink pulp coloration. An examination of the flavonoid and anthocyanin biosynthetic pathways in B. ramiflora pulp uncovered 38 differentially expressed genes associated with structural genes. The genes F3′5′H and UFGT exhibited high expression levels in the first two developmental stages of BR, significantly more than in LR, and were almost non-existent in later stages, signifying their crucial role in the differential color accumulation between BR and LR pulps. Additionally, the expression levels of CHI and FLS, early-stage structural genes in the anthocyanin synthesis pathway, correlated with the concentrations of naringenin and quercetin, indicating their importance in the anthocyanin biosynthesis pathway of B. ramiflora pulp. These discoveries provide new insights that could facilitate the breeding of B. ramiflora varieties with diverse pulp colors.
CircCNOT6L modulates alternative splicing of SLC7A11 via splicing factor SRSF2 to confer ferroptosis resistance and promote metastasis in prostate cancer
Authors: Yao Xudong , Liu Ji , Niraj Maskey , Zhu Xiaojun , Guo Yadong , Zhang Zhijin , Kadier Aimaitiaji , Gu Zhuoran , Wang Hong , Zou Libin , guo changcheng , Yang Bin , Zhang Junfeng , Mao Shiyu 
Published: March 2024

Abstract
Prostate cancer (PCa) metastasis has emerged as a leading cause of mortality globally. Due to the distinctive looping structure, circRNA has become an ideal biological tumor marker. This study aimed to investigate the mechanism and function of CircRNA, specifically circCNOT6L, on PCa metastasis. A loss-of-function assay was conducted in vitro to assess the impact of circCNOT6L on cancer cell proliferation, migration, invasion, and ferroptosis. Additionally, a xenograft mouse model was employed to elucidate circCNOT6L’s influence on subcutaneous tumor xenograft and lung metastasis. Biochemical experiments elucidated the molecular mechanism by which circCNOT6L promotes malignant progression in PCa cells by modulating ferroptosis. Additionally, the combination of CircCNOT6L-si and a ferroptosis activator was tested in organoids to evaluate their potential as suppressors of tumorigenesis. The novel circular RNA, circCNOT6L, was highly expressed in both PCa metastatic tissues and cells. circCNOT6L suppression resulted in a notable inhibition in PCa cell migration, invasion, and ferroptosis in vitro. Furthermore, circCNOT6L inhibition hindered the growth and metastasis of mouse xenografts. Mechanistically, circCNOT6L, generated by the RNA-binding protein EIF4A3, competes with miR-143-5p for binding, thereby facilitating SRSF2-dependent splicing of SLC7A11 pre-RNA. This process inhibited ferroptosis in PCa cells and promoted PCa progression. Finally, inhibiting circCNOT6L overexpression in combination with theferroptosis activator (Erastin) significantly suppressed the viability of prostate-derived organoids. In conclusion, in the present study, we found that circCNOT6L induced by EIF4A3 through the SRSF2/SLC7A11 axis effectively inhibits ferroptosis, which in turn promotes malignant progression of prostate cancer.
Ni-catalysed acceptorless dehydrogenative aromatisation of cyclohexanones enabled by concerted catalysis specific to supported nanoparticles
Authors: Yamaguchi Kazuya , Yatabe Takafumi , Matsuyama Takehiro , Yabe Tomohiro 
Published: March 2024

Abstract

The dehydrogenative aromatisation of cyclohexanone derivatives has had a transformative influence on the synthesis of aromatic compounds because functional groups can be easily introduced at desired positions via classic organic reactions without being limited by ortho-, meta- or para-orientations. However, research is still limited on acceptorless dehydrogenative aromatisation, especially with regard to nonprecious-metal catalysts. Ni is a promising candidate catalyst as a congener of Pd, but thermally Ni-catalysed dehydrogenative aromatisation has not been reported even in an oxidative manner because of the difficulty of b-hydride elimination and the fast re-insertion of Ni–H species. Here, we report a CeO2-supported Ni(0) nanoparticle catalyst for acceptorless dehydrogenative aromatisation of cyclohexanone derivatives. This catalyst is widely applicable to various compounds such as cyclohexanols, cyclohexylamines, N-heterocycles, enamines and N-alkyl piperidones. Through various experiments, we demonstrate that the present reaction was achieved by the concerted catalysis utilizing metal ensembles unique to supported metal nanoparticle catalysts.
Physicians' Views and Knowledge on the Antibiotic Treatment of Pneumonia in Advanced Dementia
Authors: Harpaz Itai , Punchik Boris , Freud Tamar , Press Yan 
Published: March 2024

Abstract

Background
Antibiotic treatment (AT) for patients with advanced dementia and pneumonia is a complex issue. AT can prolong life, but it can also prolong suffering for the patient and the family. In this study we evaluated physicians’ attitudes to this issue.
Methods
A vignette-based survey among community-based physicians (CBP) and hospital-based physicians (HBP) who work in southern Israel. The physicians were asked to complete a questionnaire on their knowledge and attitudes to AT, based on a case description of a patient with advanced dementia and pneumonia.
Results
211 physicians participated in the study including 134 CBP (63.5%) and 77 HBP (36.5%). 177 physicians chose the AT option for the patient presented in the case, with 59.7% of the HBP and 32.8% of the CBP choosing intravenous (IV) AT (p = 0.017). In contrast, in the same case, but with themselves as the patient, 68.8% of HBP and 32.8% of CBP chose the option of palliative care without AT, with only 14.3% of HBP and 10.4% of CBP choosing the option of hospitalization with IV AT. In two logistic regression models, physicians who chose IV AT for themselves were fourfold more likely to make a similar choice for their patients. Over 75% of the physicians were not knowledgeable about the administration of AT in accordance with the Dying Patient Act.
Conclusions
The results of this study indicate the need for an educational intervention among physicians to expand their knowledge and expertise on end-of-life treatment for patients with advanced dementia. In addition, we invite policy makers to convene a discussion on the possibility of changing the law to facilitate the conduct of studies of patients with advanced dementia. Such studies would make it possible to develop an evidence-based treatment strategy.
Metastatic cancer patients hospitalized at initial diagnosis: when does rescue systemic therapy make sense?
Authors: Vercueil Colin , Varnier Romain , Seban Romain , Ciaptacz Lisa , Pavillet Julien , Fraisse Cléa , Darbas Tiffany , Abdallahoui Safa , Cox David , Martin Sophie , Trensz Philippe , Kurtz Jean-Emmanuel , Gantzer Justine , Amé Shanti , Bouleuc Carole , Chvetzoff Gisèle , Eberst Lauriane 
Published: March 2024

Abstract

Purpose Therapeutic management of metastatic cancer patients who are hospitalized at the time of initial diagnosis because of impaired performance status and/or severe symptoms is challenging for clinicians. This study describes their outcome and the effect of systemic anti-neoplastic treatment (SANT) initiation on survival.Methods In this prospective multicentric study, we included all adult, inpatients with newly diagnosed metastatic solid tumors. Our primary objective was to describe overall survival (OS). Secondary objectives included assessing SANT effectiveness, identifying factors influencing initiation of SANT, and assessing usual prognostic tools and factors associated with response.Results 107 patients were included over a six-month period. Seventy-four (69%) initiated a SANT. Among them, 39 patients were alive at 3 months. Median overall survival was 1.7 months for the entire cohort. Thirty-seven patients (55%) died in the unit where they were first admitted. Patients with chemo-sensitive tumors or targeted therapy for specific molecular alterations showed better outcomes. Factors associated with the initiation of a SANT were young age (OR = 0,94 [0,90; 0,98]), low Charlson Comorbidity Index (OR = 0,56 [0,42; 0,73]), and patient’s or caregiver’s request for treatment (OR = 0,07 [0,02; 0,17] and 0,17 [0,06; 0,42], respectively).Conclusion Metastatic cancer patients hospitalized at the time of diagnosis share a similar poor survival. With the notable exception of chemosensitive tumors and specific molecular alterations, initiation of SANT seems to have a limited impact on their outcomes. Best supportive care can be reasonably considered for these patients. The benefit of SANT in this altered population should be assessed in larger prospective studies.
The Silent Contributors: A Qualitative Study to Bridge the Gap between Driver Behavior and Systemic Issues Interactions to Crashes
Authors: Mortazavi Seyed Meysam , Sadeghi-Bazargani Homayoun , Charkhabi Soheyla Ahmadi , Rasoulzadeh Yahya , Nadrian Haidar 
Published: March 2024

Abstract

Road Traffic Crashes (RTCs) disproportionately impact Low and Middle-Income Countries (LMICs). Current interventions in LMICs primarily target road user behavior, neglecting systemic issues and casting drivers as mere contributors. Given the unique cultural, financial, and social intricacies in LMICs, this study aims to explore the latent causes of RTCs, prioritizing drivers' experiences and encompassing insights from various traffic system components. Applying a qualitative approach, data were collected through 46 semi-structured interviews with 38 participants, including drivers and experts from traffic-related organizations. Content analysis identified ten themes as contributing to driving errors. Direct factors included fatigue influenced by economic and occupational conditions, distraction from internal and external sources, reckless behaviors influenced by traffic culture and environment, and Inadequate driving skills due to training. Macro-scale challenges in road infrastructure, vehicle quality, education, and accident investigations were highlighted. The lack of a centralized traffic safety authority and a predominant focus on penalizing drivers overshadowed systemic issues. The study offers valuable insights into the complex interplay of factors contributing to driving errors in LMICs, advocating for a paradigm shift towards holistic, systemic interventions beyond individual driver behavior and challenging the conventional blame-centric view associated with driving errors.
Biosynthesized silver nanoparticles mediated by Ammi visnaga extract enhanced systemic resistance and triggered multiple defense-related genes, including SbWRKY transcription factors, against tobacco mosaic virus infection
Authors: Aseel Dalia G. , Ibrahim Omar M. , Abdelkhalek Ahmed 
Published: March 2024

Abstract

Background
Tobacco mosaic virus (TMV) is a highly infectious plant virus that impacts a broad variety of plants and reduces crop yield around the world. Here, we assessed the effectiveness of using Ammi visnaga aqueous extract to synthesize silver nanoparticles (Ag-NPs) and their potential to combat TMV. Different techniques were used to characterize Ag-NPs, such as scanning and transmission electron microscopy (SEM, TEM), energy-dispersive X-ray spectroscopy (EDS), fourier transform infrared spectroscopy (FTIR), and dynamic light scattering (DLS).
Results
TEM demonstrated that the biosynthesized Ag-NPs had a spherical form with an average size of 25 nm. The zeta potential indicated the high stability of Ag-NPs, with a value of -15.9 mV. FTIR revealed various functional groups involved in the stability and capping of Ag-NPs. Interestingly, the Pre-treatment of tobacco plants (protective treatment) with Ag-NPs at 100 or 500 µg/mL significantly suppressed viral symptoms, while the Post-treatment (curative treatment) delayed their appearance. Furthermore, protective and curative treatments significantly increased chlorophyll a and b, total flavonoids, total soluble carbohydrates, and antioxidant enzymes activity. At the same time, it caused a drop in oxidative stress markers. The RT-qPCR results and volcano plots analysis showed that the Ag-NPs treatments triggers and regulates transcriptional of ten defense-related genes (SbWRKY-1, SbWRKY-2, JERF-3, GST-1, POD, PR-1, PR-2, PR-12, PAL-1, HQT-1). The heatmap revealed that GST-1, the primary gene involved in anthocyanidin production, was consistently the most expressed gene across all treatments throughout the study. Analysis of the gene co-expression network revealed that SbWRKY-19 was the most central gene among the studied genes, followed by PR-12 and PR-2.
Conclusions
Overall, the reported antiviral properties (protective and/or curative) of biosynthesized Ag-NPs against TMV lead us to recommend using Ag-NPs as a simple, stable, and eco-friendly agent in developing pest management programs against plant viral infections.
Development of a novel rodent model for dog heartworm microfilaremia using the severe-combined immunodeficiency mouse
Authors: Mizuseki Mihoko , Ikeda Nao , Shirozu Takahiro , Ymagishi Maki , Oshiro Sugao , Fukumoto Shinya 
Published: March 2024

Abstract

Dirofilaria immitis is a mosquito-borne parasitic nematode that causes fatal heartworm disease in canids. The fine microfilariae are essential for research, including drug screening and mosquito-parasite interactions. However, no reliable methods for maintaining fine microfilaria long-term are currently available. Therefore, we used severe combined immunodeficiency (SCID) mice to develop a reliable method for maintaining D. immitis microfilaria. SCID mice were injected intravenously with microfilariae isolated from a D. immitis-infected dog. Microfilariae were detected in blood collected from the tail vein 218 days post-inoculation (dpi) and via cardiac puncture 296 dpi. Microfilariae maintained in and extracted from SCID mice showed infectivity and matured into third-stage larvae (L3s) in the vector mosquito Aedes aegypti. L3s can develop into the fourth stage larvae in vitro. Microfilariae from SCID mice respond normally to ivermectin in vitro. The microfilariae in SCID mice displayed periodicity in the peripheral circulation. The SCID mouse model aided in the separation of superior microfilariae from cryopreserved specimens. The use of SCID mice enabled the isolation and sustained cultivation of microfilariae from clinical samples. These findings highlight the usefulness of the SCID mouse model for studying D. immitis microfilaremia in canine heartworm research.