bluuebunny/crossref_metadata_2025_split huggingface dataset:
Injectable Hydrogels: A Paradigm Tailored with Design, Characterization, and Multifaceted Approaches
Authors: Singhal Rishika , Sarangi Manoj Kumar , Rath Goutam 
Published: April 2024

AbstractBiomaterials denoting self‐healing and versatile structural integrity are highly curious in the biomedicine segment. The injectable and/or printable 3D printing technology is explored in a few decades back, which can alter their dimensions temporarily under shear stress, showing potential healing/recovery tendency with patient‐specific intervention toward the development of personalized medicine. Thus, self‐healing injectable hydrogels (IHs) are stunning toward developing a paradigm for tissue regeneration. This review comprises the designing of IHs, rheological characterization and stability, several benchmark consequences for self‐healing IHs, their translation into tissue regeneration of specific types, applications of IHs in biomedical such as anticancer and immunomodulation, wound healing and tissue/bone regeneration, antimicrobial potentials, drugs, gene and vaccine delivery, ocular delivery, 3D printing, cosmeceuticals, and photothermal therapy as well as in other allied avenues like agriculture, aerospace, electronic/electrical industries, coating approaches, patents associated with therapeutic/nontherapeutic avenues, and numerous futuristic challenges and solutions.
Effect of gap size on flange face corrosion
Authors: Hakimian Soroosh , Bouzid Abdel‐Hakim , Hof Lucas A. 
Published: April 2024

AbstractBolted flanged joints play a critical role in offshore wind turbine tower structures, serving as integral components that connect various sections of the tower. This research study employs electrochemical techniques to investigate the effect of gap dimensions, which determine the crevice gap thickness and crevice depth, on corrosion behavior of 321 stainless steel flange sample plates in a 3.5 wt% NaCl solution at 50°C. Gaskets are used in this study to create gaps between two flange surfaces. A novel fixture is utilized to simulate the applied stress on the gasket, fluid flow within the fixture, and the geometric aspects of the gasket and flange. The findings reveal that increasing the gap thickness from 1.58 to 6.35 mm results in a rise in the general corrosion rate of the flange surface from 0.09 to 1.03 mm y−1, and crevice corrosion initiation time increases from 0.23 to 3.12 h. Furthermore, reducing the crevice depth (d) from 7.49 to 0 mm leads to a decrease in the general corrosion rate from 0.09 mm y−1 to 0.04 µm y−1, and cases with d = 3.81 and d = 0 mm show no observable crevice corrosion after potentiostatic tests.
Effects of Operating Mechanical Conditions and Polymer Networks of Nematic Elastomers on Photo‐Induced Mechanical Performances
Authors: Ohzono Takuya , Koyama Emiko 
Published: April 2024

AbstractPhotoresponsive liquid‐crystalline elastomers (LCEs) are promising candidates for light‐controlled soft actuators. Photoinduced stress/strain originates from the changes in mechanical properties after light irradiation. However, the correlation between the photoinduced mechanical performance and in‐use conditions such as stress/strain states and polymer network properties (such as effective crosslink density and dangling chain density) remains unexplored for practical applications. Here, isometric photo‐induced stress or isotonic strain is investigated at different operating strains or stresses, respectively, on LCEs with polymer network variations, produced by different amounts of solvent during polymerization. As the solvent volume increases, the moduli and photoinduced stresses decrease. However, the photo‐induced strain, fracture strain, fracture stress, and viscosity increase. The optical response performance initially increases with the operating strain/stress, peaks at a higher actuation strain/stress, and then, decreases depending on the polymer network. The maximum work densities, which also depend on the operating stress, are in the range of ≈200–300 kJm−3. These findings, highlighting the significant variations in the mechanical performance with the operating stress/strain ranges and amount of solvent used in the synthesis, are critical for designing LCE‐based mechanical devices.
Molecular Imaging in CANVAS: A Contribution for Differential Diagnosis?
Authors: Horowitz Tatiana , Guedj Eric , Eusebio Alexandre , Fluchère Frédérique , Azulay Jean‐Philippe , Delmont Emilien , Grimaldi Stephan 
Published: April 2024

AbstractBackgroundPhenotypes of CANVAS are increasingly diversified, including bradykinesia and dysautonomia, so that its primary differential diagnoses are multiple system atrophy‐cerebellar type (MSA‐c), and spinocerebellar ataxia type 3 (SCA3). This case series aims to highlight key molecular imaging findings in CANVAS.CasesWe report a case series of six patients with CANVAS who underwent nuclear medicine examinations in our center and 13 patients from the literature. These include 18F‐FDG brain positron emission tomography (PET), single photon emission computed tomography (SPECT) of dopamine transporter (DaT) activity, and 123I‐MIBG cardiac scintigraphy of noradrenergic transmission.ConclusionsIn CANVAS, 18F‐FDG brain PET mainly shows cerebellar hypometabolism, with preserved brainstem and striatum metabolism, contrasting with SCA3 and MSA‐c. Dopaminergic denervation on scintigraphy seems to be associated with clinical parkinsonism, ranging from normal to severely impaired DaT SPECT. Additionally, 123I‐MIBG cardiac scintigraphy might show denervation in CANVAS, similar to SCA3, but not in most MSA‐c patients.
Detection of early pulmonary emphysema by multi‐contrast x‐ray Talbot‐Lau interferometer
Authors: Lin Qisi , Wu Zhao , Huang Meng , Dang Zheng , Tian Lijiao , Guan Yong , Liu Gang , Lu Yalin , Tian Yangchao 
Published: April 2024

AbstractBackgroundPulmonary emphysema is a part of chronic obstructive pulmonary disease, which is an irreversible chronic respiratory disease. In order to avoid further damage to lung tissue, early diagnosis and treatment of pulmonary emphysema is essential.PurposeEarly pulmonary emphysema diagnosis is difficult with conventional radiographic imaging. Recently, x‐ray phase contrast imaging has proved to be an effective and promising imaging strategy for soft tissue, due to its high sensitivity and multi‐contrast. The aim of this study is to diagnose pulmonary emphysema early utilizing an x‐ray Talbot‐Lau interferometer (TLI).MethodsWe successfully established the mouse model of emphysema by porcine pancreatic elastase treatment, and then used the established x‐ray TLI to perform imaging experiments on the mice with different treatment time. The traditional absorption CT and phase contrast CT were obtained simultaneously through TLI. The CT results and histopathology of mice lung in different treatment time were quantitatively analyzed.ResultsBy imaging mice lungs, it can be found that phase contrast has higher sensitivity than absorption contrast in early pulmonary emphysema. The results show that the phase contrast signal could distinguish the pulmonary emphysema earlier than the conventional attenuation signal, which can be consistent with histological images. Through the quantitative analysis of pathological section and phase contrast CT, it can be found that there is a strong linear correlation.ConclusionsIn this study, we quantitatively analyze mean linear intercept of histological sections and CT values of mice. The results show that the phase contrast signal has higher imaging sensitivity than the attenuation signal. X‐ray TLI multi‐contrast imaging is proved as a potential diagnostic method for early pulmonary emphysema in mice.
Does self‐organizing policy network provide effective waste services? An empirical evaluation of institutional collective action and transaction cost dilemmas
Authors: Abreu Mônica Cavalcanti Sá de , da Silva Lucineide Alves , Consciência Silvestre Hugo , Emmendoerfer Magnus Luiz 
Published: April 2024

AbstractThis paper examines institutional collective action and transaction cost (TC) dilemmas in a self‐organizing policy network involving federal, state, and municipal agencies for waste services in a port and industrial park. A thematic analysis revealed dilemmas in: (a) vertical levels, which lack leadership in industrial waste management due to unclear responsibility delegation across government levels; (b) horizontal levels, reluctant to take responsibilities and define jurisdiction boundaries for efficient waste services; and (c) functional levels, which exhibit fragmented and unaligned action scopes. Transaction costs, stemming from a deficiency in expertise, infrastructure, and organized information regarding companies' waste management, hinder effective programs and policies. Without tackling these challenges and TCs through a governance framework that includes implementation strategies, monitoring, and institutional controls, the self‐organizing policy network is likely to remain stuck in collective institutional inertia.
An assessment of the role of nanosilica in thermal/thermo‐oxidative degradation mechanism of poly(lactic acid)/polybutylene adipate terephthalate blend nanocomposites
Authors: Khonakdar Hanieh , Khasraghi Samaneh Salkhi , Yazdanbakhsh Amir Hossein , Mousavi Seyed Rasoul , Ahmadi Shervin , Arabi Hasan , Nobre Marcos A. L. , Khonakdar Hossein Ali 
Published: April 2024

AbstractAs a packaging materials candidate, based on a polylactic acid/ polybutylene adipate terephthalate (PLA/PBAT) blends (90/10 and 75/25 wt/wt) containing 1, 3, and 5 phr hydrophilic (HPL) and hydrophobic (HPB) nanosilica (NS) particles in the presence of a multifunctional epoxide compatibilizer were prepared by melt mixing, in a twin‐screw extruder. Scanning electron microscopic studies confirmed a matrix‐droplet morphology with finer dispersed domains at higher NS content. Energy dispersive spectroscopy mapping also indicated uniform dispersion of NS in blends, with some agglomerates at higher content of nanoparticles. Moreover, transmission electron microscope was applied to study the impact of nanofillers' localization on the systems' morphology. It was observed that NS particles localized at the PLA‐PBAT interface. In addition, thermogravimetric analysis (TGA) was used to investigate thermal stability and thermal degradation kinetics. Data indicates that hydrophobic NS improved thermal stability. The activation energy of degradation was calculated using several techniques of data modeling, including Friedman, Flynn‐Ozawa‐Wall, and Kissinger‐Akahira‐Sunose models. Among blend nanocomposites, 75/25 blend containing 5 phr HPB NS had the maximum degradation activation energy, suggesting that this sample had the most resistance to heat degradation. The intensity of the TGA/FTIR peaks of the evolved products was found to be correlated with the activation energy. The Criado's technique was also used to investigate the changes in the thermal degradation mechanism.
Magnetorheological response of Permalloy@ styrene‐b‐(ethylene‐co‐butylene)‐b‐styrene elastomers as a function of filler concentration
Authors: Díez Ander García , Tubio Carmen Rial , Gómez Ainara , Berasategi Joanes , San Miguel‐Gutiérrez M. , Notario B. , Mounir Bou‐Ali M. , Etxebarria Jon Gutiérrez , Lanceros‐Mendez Senentxu 
Published: April 2024

AbstractDeveloping advanced magnetorheological elastomers (MREs) with a range of specific characteristics is essential for matching the growing demands from a wide spectrum of applications such as automotive, healthcare, sensors, and actuators. However, the compatibility problems between constituents and the low magnetorheological (MR) effect have limited their performance and integration into actual applications. Here, a novel MRE consisting of styrene‐b‐(ethylene‐co‐butylene)‐b‐styrene (SEBS) and Ni‐rich Permalloy (Ni80Fe17Mo3) has been developed with remarkable functional properties. The correlation between the filler concentration and microstructural, mechanical, thermal, magnetic, and MR properties is reported. The incorporation of Ni‐rich Permalloy has a reinforcement effect in the polymer matrix and leads to an improvement of the thermal stability. Further, the saturation magnetization and remanence of the composites increase with increasing filler content. In particular, the saturation magnetization increases from 14.3 to 41.9 A m2/kg, and the remanence from 1.2 to 4.0 A m2/kg when the concentration increases from 20 to 60 wt%. Finally, the MR effect of composites with 20, 40, and 60 wt% filler content is 8%, 15%, and 35%, respectively. A magnetic dipole interaction model is used to discuss the MR effect and a relation between the MR effect and the main parameters affecting it is proposed. Importantly, the obtained MR values are higher when compared with related composites for the same magnetic content, and for the same or similar polymeric matrices, demonstrating the suitability of the developed materials for the fabrication of high‐response functional MR devices.
A nationwide phase II study of delayed local treatment for children with high‐risk neuroblastoma: The Japan Children's Cancer Group Neuroblastoma Committee Trial JN‐H‐11
Authors: Yoneda Akihiro , Shichino Hiroyuki , Hishiki Tomoro , Matsumoto Kimikazu , Ohira Miki , Kamijo Takehiko , Kuroda Tatsuo , Soejima Toshinori , Nakazawa Atsuko , Takimoto Tetsuya , Yokota Isao , Teramukai Satoshi , Takahashi Hideto , Fukushima Takashi , Hara Junichi , Kaneko Michio , Ikeda Hitoshi , Tajiri Tatsuro , Mugishima Hideo , Nakagawara Akira 
Published: April 2024

AbstractPurposeSurvival rates of patients with high‐risk neuroblastoma are unacceptable. A time‐intensified treatment strategy with delayed local treatment to control systemic diseases has been developed in Japan. We conducted a nationwide, prospective, single‐arm clinical trial with delayed local treatment. This study evaluated the safety and efficacy of delayed surgery to increase treatment intensity.Patients and methodsSeventy‐five patients with high‐risk neuroblastoma were enrolled in this study between May 2011 and September 2015. Delayed local treatment consisted of five courses of induction chemotherapy (cisplatin, pirarubicin, vincristine, and cyclophosphamide) and myeloablative high‐dose chemotherapy (melphalan, etoposide, and carboplatin), followed by local tumor extirpation with surgery and irradiation. The primary endpoint was progression‐free survival (PFS). The secondary endpoints were overall survival (OS), response rate, adverse events, and surgical complications.ResultsSeventy‐five patients were enrolled, and 64 were evaluable (stage 3, n = 8; stage 4, n = 56). The estimated 3‐year PFS and OS rates (95% confidence interval [CI]) were 44.4% [31.8%–56.3%] and 80.7% [68.5%–88.5%], resspectively. The response rate of INRC after completion of the treatment protocol was 66% (42/64; 95% CI: 53%–77%; 23 CR [complete response], 10 VGPR [very good partial response], and nine PR [partial response]). None of the patients died during the protocol treatment or within 30 days of completion. Grade 4 adverse effects, excluding hematological adverse effects, occurred in 48% of patients [31/64; 95% CI: 36%–61%]. Major Surgical complications were observed in 25% of patients [13/51; 95% CI: 14%–40%].ConclusionThis study indicates that delayed local treatment is feasible and shows promising efficacy, suggesting that this treatment should be considered further in a comparative study of high‐risk neuroblastoma.
Improved disease tolerance, higher seed yield and shape in dark red kidney bean: Registration of ‘ND Redbarn’
Authors: Osorno Juan M. , Erfatpour Mohammad , Simons Kristin J. , Maisonneuve Makenson , Posch John , Vander Wal Albert J. 
Published: April 2024

Abstract‘ND Redbarn’ (PVP. no. 202300271; Reg. no. CV‐357, PI 703021) is a new dark red kidney bean (Phaseolus vulgaris L.) cultivar developed by the Dry Edible Bean Breeding Program at North Dakota State University and released in 2023 by the North Dakota Agricultural Experiment Station. Compared to other market classes, kidney beans usually command higher prices. However, kidney beans are less productive than other market classes. Minnesota is the largest dark red kidney bean producer in the United States, accounting for ∼90% of the total production in 2022. ND Redbarn was released based on its good adaptation to this region, higher seed yield, large seed size, and desirable seed shape characteristics. Between 2012 and 2021, ND Redbarn was tested across 16 environments in Minnesota, where seed yield was significantly higher than commercial checks ‘Montcalm’, ‘Red Hawk’, and ‘Talon’ (14%, 27%, and 9%, respectively) and comparable with ‘Dynasty’. ND Redbarn is resistant to Bean common mosaic virus and has intermediate resistance to common bacterial blight. ND Redbarn exhibits higher field tolerance to the root rot fungal complex infection compared to Montcalm, Red Hawk, and Talon, and is similar to Dynasty. ND Redbarn has shown higher levels of tolerance to white mold than Montcalm and Red Hawk. Under Minnesota environments, ND Redbarn shows an average plant height of 51 cm, has a 100‐seed weight of 50.4 g, and matures in approximately 99 days. The canning quality for Redbarn is within acceptable commercial ranges.
Seed yield improvements in slow‐darkening pinto bean: Registration of ‘ND Rodeo’
Authors: Osorno Juan M. , Erfatpour Mohammad , Simons Kristin J. , Maisonneuve Makenson , Posch John , Vander Wal Albert J. 
Published: April 2024

Abstract‘ND Rodeo’ (PVP no. 202300270; Reg. no. CV‐356, PI 703020) is a new slow‐darkening (SD) pinto bean (Phaseolus vulgaris L.) cultivar developed by the Dry Edible Bean Breeding Program at North Dakota State University and released by the North Dakota Agricultural Experiment Station. Pinto bean is the largest market class grown in the United States, representing over 47% of the total US production for dry beans, and more than 70% is produced in North Dakota. SD pinto beans offer a good alternative to commercial cultivars of regular darkening (RD) pinto beans, which are typically subject to the risk of economic losses due to seed coat darkening. However, reaching seed yields comparable to RD pintos has been challenging. Between 2017 and 2022, ND Rodeo was tested across 25 environments in North Dakota, where seed yield was significantly higher than the SD pinto cultivars ‘ND Palomino’ and ‘Vibrant’ (18% and 22%, respectively), and comparable with RD pinto cultivars ‘La Paz’ and ‘Monterrey’. ND Rodeo is resistant to Bean common mosaic virus and has intermediate resistance to common bacterial blight, but similar to the commercial checks, it is susceptible to local races/strains of white mold, anthracnose, and rust pathogens. ND Rodeo has an average height of 56 cm which is significantly higher than the average of ND Palomino, Vibrant, and La Paz, and exhibits a desirable upright architecture to facilitate direct harvest. It has a 100‐seed weight of 36.2 g and matures in 102 days. Canning quality was rated as acceptable.
The measurement of one‐electron redox potentials of free radicals
Authors: Khudyakov Igor V. 
Published: April 2024

AbstractThe paper is devoted to the measurements of one‐electron redox potentials of transient free radicals Eo. These values can be measured in the reversible redox reactions of radicals under investigation with a reference pair, which Eo is known. Several Eo of transient radicals are presented. The convenient and important objects for Eo measurement are quinone/semiquinone radical‐anions. A general problem of measurement of thermodynamic properties of short‐lived transients is discussed.
Modulation of atherosclerosis‐related signaling pathways by Chinese herbal extracts: Recent evidence and perspectives
Authors: Liu Changxing , Guo Xinyi , Zhang Xulong 
Published: April 2024

AbstractAtherosclerotic cardiovascular disease remains a preeminent cause of morbidity and mortality globally. The onset of atherosclerosis underpins the emergence of ischemic cardiovascular diseases, including coronary heart disease (CHD). Its pathogenesis entails multiple factors such as inflammation, oxidative stress, apoptosis, vascular endothelial damage, foam cell formation, and platelet activation. Furthermore, it triggers the activation of diverse signaling pathways including Phosphatidylinositol 3‐kinase/protein kinase B (PI3K/Akt), NF‐E2‐related factor 2/antioxidant response element (Nrf2/ARE), the Notch signaling pathway, peroxisome proliferator‐activated receptor (PPAR), nucleotide oligo‐structural domain‐like receptor thermoprotein structural domain‐associated protein 3 (NLRP3), silencing information regulator 2‐associated enzyme 1 (Sirt1), nuclear transcription factor‐κB (NF‐κB), Circular RNA (Circ RNA), MicroRNA (mi RNA), Transforming growth factor‐β (TGF‐β), and Janus kinase‐signal transducer and activator of transcription (JAK/STAT). Over recent decades, therapeutic approaches for atherosclerosis have been dominated by the utilization of high‐intensity statins to reduce lipid levels, despite significant adverse effects. Consequently, there is a growing interest in the development of safer and more efficacious drugs and therapeutic modalities. Traditional Chinese medicine (TCM) offers a vital strategy for the prevention and treatment of cardiovascular diseases. Numerous studies have detailed the mechanisms through which TCM active ingredients modulate signaling molecules and influence the atherosclerotic process. This article reviews the signaling pathways implicated in the pathogenesis of atherosclerosis and the advancements in research on TCM extracts for prevention and treatment, drawing on original articles from various databases including Google Scholar, Medline, CNKI, Scopus, and Pubmed. The objective is to furnish a reference for the clinical management of cardiovascular diseases.
NF‐κB affected the serum levels of TNF‐α and IL‐1β via activation of the MAPK/NF‐κB signaling pathway in rat model of acute pulmonary microthromboembolism
Authors: Zhong Yanfen , Liang Binbin , Zhang Xiaofeng , Li Jingtao , Zeng Decai , Huang Tongtong , Wu Ji 
Published: April 2024

AbstractPulmonary thromboembolism caused by thrombi blocking major pulmonary artery and its branches, is a frequently encountered phenomenon and an important cause of high morbidity and mortality in lung diseases and may develop into persistent pulmonary hypertension (PH). Nuclear factor‐κB (NF‐κB) signaling pathway had been reported participated in the formation and development of PH by promoting inflammatory response. The aim of this study was to investigate the effects of NF‐κB activation on the serum levels of tumor necrosis factor α (TNF‐α) and interleukin‐1β (IL‐1β) in acute pulmonary microthromboembolism (APMTE) rats. Rats were randomized into five groups. APMTE group received jugular vein injection of autologous thrombus, while control group rats received normal saline injection. Pulmonary hemodynamic parameters were measured through ECHO‐guided transthoracic puncture. Pulmonary vascular morphological changes were analyzed by HE. The expression changes of NF‐κB and serum TNF‐α、IL‐1β levels were detected by enzyme‐linked immunosorbent assay. Protein expression of the MAPK/NF‐κB signaling pathway including p‐IκBα, p‐p38 MAPK, p‐NF‐κB p65, IκBα, p38 MAPK, and NF‐κB p65 was determined using western blot analysis. Compared with control group, the expression of NF‐κB in lung tissue and the levels of serum TNF‐α and IL‐1β rats were higher, a significant reduction in IκBα and elevation in the phosphorylation of IκBα, p38 MAPK, and NF‐κB p65 were found in APMTE group rats. And UK administration reversed the APMTE‐induced increase in TNF‐α, IL‐1β, p‐IκBα, p‐MAPK, and p‐NF‐κB protein. Furthermore, the levels of NF‐κB, TNF‐α, and IL‐1β were positively correlated with mean pulmonary artery. And the levels of TNF‐α and IL‐1β were positively correlated with NF‐κB. These findings suggest that the activation of MAPK/NF‐κB pathway as a critical driver of increasing TNF‐α and IL‐1β level in APMTE rats and UK exerted protective effects against APMTE‐induced PH may be related to the downregulation of the MAPK/NF‐κB signaling pathway.