bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Pyroglutamate Hydantoin Rearrangement.
Authors: Dieltiens Nicolai , Claeys Diederica D. , Zhdankin Viktor V. , Nemykin Victor N. , Allaert Bart , Verpoort Francis , Stevens Christian V. 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rapid Microwave‐Assisted Synthesis of 3‐Substituted 4‐Thioxo‐oxazolidin‐2‐ones.
Authors: Kurz Thomas , Khankischpur Mehdi , Widyan Khalid 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Furan‐Containing Thiacyanine Analogues and Their Antimicrobial Activity.
Authors: Kortisova I. , Foltinova P. , Halgas J. 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Biological Activity of New 1,3,4‐Thiadiazole Derivatives.
Authors: Aly A. A. , El‐Sayed R. 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Biomimetic Aromatization of Hantzsch 1,4‐Dihydropyridines with Sodium Periodate Catalyzed by a New Polystyrene‐Bound Manganese Porphyrin.
Authors: Moghadam Majid , Nasr‐Esfahani Masoud , Tangestaninejad Shahram , Mirkhani Valiollah , Zolfigol Mohammad Ali 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Difluorinated Pyridinecarboxaldehyde via Electrophilic Fluorination
Authors: Ko Yoon‐Joo , Park Kyung‐Bae , Shim Seung‐Bo , Shin Jung‐Hyu 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 1‐[N‐(Aryl)methylcarbamoyl]‐1,10‐phenanthrolinium Iodides (III) with Potential Biological Activity.
Authors: Dumitrascu Florea , Draghici Constantin , Caira Mino R. , Badoiu Andrei , Barbu Loredana 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Straightforward Synthetic Approach to Antitumoral Pyridinyl Substituted 7H‐Indeno[2,1‐c]quinoline Derivatives via Three‐Component Imino Diels—Alder Reaction.
Authors: Kouznetsov Vladimir V. , Puentes Cristian Ochoa , Bohorquez Arnold R. Romero , Zacchino Susana A. , Sortino Maximiliano , Gupta Mahabir , Vazquez Yelkaira , Bahsas Ali , Amaro‐Luis Juan 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Anxiolytic Activity of 1‐Phenyl‐2‐(4‐aryl‐1,3,4,5‐tetrahydropyrido[2,3‐b] [1,4]diazepin‐2‐ylidene)‐ethanone.
Authors: Liszkiewicz H. , Kowalska M. W. , Rutkowska M. , Gliniak H. 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Enantioselective Aerobic Oxidation of α‐Hydroxyphosphonates Catalyzed by Chiral Vanadyl(IV) Methoxides Bearing N‐Salicylidene‐α‐aminocarboxylates.
Authors: Pawar Vijay D. , Bettigeri Sampada , Weng Shiue‐Shien , Kao Jun‐Qi , Chen Chien‐Tien 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cell Permeation of a Trypanosoma brucei Aldolase Inhibitor: Evaluation of Different Enzyme‐Labile Phosphate Protecting Groups
Authors: Azema Laurent , Lherbet Christian , Baudoin Cecile , Blonski Casimir 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Sesquiterpene Glycoside from the Roots of Pteris multifida Poir
Authors: Hu Haobin , Jian Yufeng , Zheng Xudong , Liu Jianxin , Cao Hong 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Trifluoromethylated Analogues of β‐L‐Fucofuranose and β‐L‐4,6‐Dideoxyxylohexopyranose.
Authors: Wang Bing‐Lin , Yu Fei , Qiu Xiao‐Long , Jiang Zhong‐Xing , Qing Feng‐Ling 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Antioxidant Flavonoids from Pulicaria undulata
Authors: Ahmad V. U. , Rasool N. , Abbasi M. A. , Rashid M. A. , Kousar F. , Zubair M. , Ejaz A. , Choudhary M. I. , Tareen R. B. 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Isolation of New Straight Chain Compounds from Acacia nilotica.
Authors: Chaubal Rohini , Tambe Amruta , Biswas Sujata , Rojatkar Supada , Deshpande Vishnu , Deshpande Nirmala 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
First Enantioselective Synthesis of (‐)‐Talaumidin, a Neurotrophic Diaryltetrahydrofuran‐Type Lignan.
Authors: Esumi Tomoyuki , Hojyo Daisuke , Zhai Haifeng , Fukuyama Yoshiyasu 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
3‐Normeridamycin: A Potent Non‐Immunosuppressive Immunophilin Ligand is Neuroprotective in Dopaminergic Neurons.
Authors: Summers Mia Y. , Leighton Margaret , Liu Danni , Pong Kevin , Graziani Edmund I. 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New 5‐Alkenylresorcinol Sch 725681 from Aspergillus sp.
Authors: Yang Shu‐Wei , Chan Tze‐Ming , Terracciano Joseph , Loebenberg David , Patel Mahesh , Gullo Vincent , Chu Min 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
2‐(Trimethylsilyl)ethanesulfonyl (or SES) Group in Amine Protection and Activation
Authors: Ribiere Patrice , Declerck Valerie , Martinez Jean , Lamaty Frederic 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemistry of 2‐Acetyl‐1‐pyrroline, 6‐Acetyl‐1,2,3,4‐tetrahydropyridine, 2‐Acetyl‐2‐thiazoline, and 5‐Acetyl‐2,3‐dihydro‐4H‐thiazine: Extraordinary Maillard Flavor Compounds
Authors: Adams An , De Kimpe Norbert 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Melanocortin‐4 Receptor (MC4R) Agonists for the Treatment of Obesity.
Authors: Nargund Ravi P. , Strack Alison M. , Fong Tung M. 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Syntheses of Morphine and Codeine (1992‐2002): Templates for Exploration of Synthetic Tools
Authors: Mascavage L. M. , Wilson M. L. , Dalton D. R. 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Kinetics and Mechanism of Ozonized Oxidation of Ketones
Authors: Zimin Yu. S. , Monakov Yu. B. , Komissarov V. D. 
Published: September 2006

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Selective use of sentinel lymph node surgery during prophylactic mastectomy
Authors: Boughey Judy C. , Khakpour Nazanin , Meric‐Bernstam Funda , Ross Merrick I. , Kuerer Henry M. , Singletary Sonja E. , Babiera Gildy V. , Arun Banu , Hunt Kelly K. , Bedrosian Isabelle 
Published: September 2006

AbstractBACKGROUND.Patients with invasive cancer identified at the time of prophylactic mastectomy (PM) will require axillary lymph node dissection for staging; therefore, many surgeons advocate sentinel lymph node (SLN) surgery at the time of PM. The current study investigates the invasive cancer rate in PM and evaluates factors associated with invasive cancer to guide SLN surgery use.METHODS.Patients undergoing PM at the M. D. Anderson Cancer Center between January 2000 and July 2005 were identified from a prospective database. Clinical, radiographic, and pathologic data were collected.RESULTS.A total of 409 patients (436 PM cases) were identified; 382 underwent contralateral PM (CPM) and 27 underwent bilateral PM (BPM). Cancer was identified in 22 of 436 PM cases (5%). Of these, 14 patients (64%) had ductal carcinoma in situ (DCIS). Only 8 patients (1.8%) had invasive cancer, with a mean tumor size of 5 mm (range, 2–9 mm). There was no difference in the occult cancer rate between CPM and BPM. No cases of invasive cancer were identified in the 23 patients with BRCA mutations. Significantly increased risk of invasive cancer in the PM breast was seen in postmenopausal patients (3.7%; P = .007), patients age >60 years (7.5%; P = .008), and patients with history of invasive lobular carcinoma (9.7%; P = .0002) or lobular carcinoma in situ (LCIS) (7.7%; P = .008).CONCLUSIONS.The frequency of cancer in PM is very low and the majority represents DCIS. Therefore, routine use of SLN surgery in all patients undergoing PM is not warranted. However, patients at higher risk for whom SLN surgery should be considered include older women and patients with a history of lobular cancer or LCIS. Cancer 2006. © 2006 American Cancer Society.
Activity of 9‐nitro‐camptothecin, an oral topoisomerase I inhibitor, in myelodysplastic syndrome and chronic myelomonocytic leukemia
Authors: Quintas‐Cardama Alfonso , Kantarjian Hagop , O'Brien Susan , Jabbour Elias , Giles Francis , Ravandi Farhad , Faderl Stefan , Pierce Sherry , Shan Jenny , Verstovsek Srdan , Cortes Jorge 
Published: September 2006

AbstractBACKGROUND.Topoisomerase I inhibitors, like topotecan, have activity in myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML). 9‐Nitro‐camptothecin (9‐NC) is a new oral topoisomerase inhibitor with a good safety profile. The aims of the current study were to evaluate the activity and safety of 9‐NC in MDS and CMML.METHODS.Adults with a diagnosis of MDS (n = 12) and CMML (n = 32) received 9‐NC 2 mg/m2 orally daily 5 days a week, every 4 to 6 weeks.RESULTS.Overall, 5 (11%) patients achieved complete response (CR), 7 (16%) had a partial response (PR), and 6 (14%) had hematologic improvement (HI), for an overall response rate of 41%. The response rate was similar in MDS and CMML. Severe (Grade 3–4) side effects included nausea and vomiting (7%), diarrhea (18%), other gastrointestinal toxicities (5%), and genitourinary toxicities (12%).CONCLUSIONS.9‐NC is active in MDS and CMML. The paucity of available therapies in CMML makes 9‐NC a good candidate for further studies as a single agent, or in combination with decitabine, 5‐azacitidine or cytarabine. Cancer 2006. © 2006 American Cancer Society.
Treatment of metastatic sarcoma to the liver with bland embolization
Authors: Maluccio Mary A. , Covey Anne M. , Schubert Johanna , Brody Lynn A. , Sofocleous Constantinos T. , Getrajdman George I. , DeMatteo Ronald , Brown Karen T. 
Published: September 2006

AbstractBACKGROUND.The authors evaluated the impact of bland particle embolization on survival in patients with metastatic sarcoma to the liver.METHODS.Twenty‐four patients with liver‐dominant metastases from sarcoma were treated with particle embolization from 1996 to 2002. Primary tumors included 16 gastrointestinal stromal tumors (GISTs), 7 intestinal leiomyosarcomas, and 1 liposarcoma. Thirteen patients had known extrahepatic disease. Embolization was performed by using polyvinyl alcohol or trisacryl microspheres to effect stasis in the target vessel(s). Follow‐up images to assess response were obtained 4 weeks after the procedure. Decrease in the size of the target lesion by >25% or development of >50% necrosis on follow‐up imaging was considered a treatment response.RESULTS.Nineteen patients had metachronous liver metastases, and the median disease‐free interval was 22 months (range 10–156 months) from resection of the primary tumor. Ten patients underwent prior liver resection for metastatic disease. Of 15 evaluable patients, 9 patients (60%) had a radiographic response. The median follow‐up for all patients was 21 months. The median follow‐up for surviving patients was 59 months. Overall survival from the time of initial embolization was 62% at 1 year, 41% at 2 years, and 29% at 3 years. Patients who had radiographic evidence of response survived significantly longer than patients who did not respond (63 months vs. 19 months; P < .007). Patients with GIST survived significantly longer than patients with visceral leiomyosarcoma (median, 36 months vs. 18 months; P < .03).CONCLUSIONS.Bland embolization was efficacious in some patients with metastatic sarcoma to the liver. Radiographic evidence of response was correlated with improved survival. This regional therapy may enter the treatment algorithm for patients who have unresectable disease or disease that has failed conventional therapies. Cancer 2006. © 2006 American Cancer Society.
Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase
Authors: Ceppi Paolo , Volante Marco , Saviozzi Silvia , Rapa Ida , Novello Silvia , Cambieri Alberto , Lo Iacono Marco , Cappia Susanna , Papotti Mauro , Scagliotti Giorgio V. 
Published: September 2006

AbstractBACKGROUND.In patients with cancer, one of the main mechanism of resistance to antimetabolite drugs is related to higher levels of thymidylate synthase (TS) activity.METHODS.To investigate the association between TS expression and histopathologic data, 56 resection specimens from patients with nonsmall cell lung carcinoma (NSCLC) were collected consecutively. TS messenger RNA (mRNA) was evaluated in tumor specimens by using real‐time polymerase chain reaction (PCR) analysis; protein expression was evaluated by using immunohistochemistry (IHC) in formalin‐fixed, paraffin‐embedded (FFPE) specimens; and the analysis of TS transcriptional regulation activity was performed by using real‐time PCR analysis in snap‐frozen normal and tumor specimens.RESULTS.The amplification of the TS gene from FFPE tissues was obtained from all samples, with a median level (unit‐less ratio) of 1.45 (range, 0.34–5.24); whereas positive TS status at IHC (>10% positive cells) was detected in 56% of samples. It is noteworthy that TS expression was significantly higher in squamous cell carcinoma compared with adenocarcinoma when both mRNA levels (2.17 vs. 1.16; P < .0001) and protein levels (P = .0269) were considered in FFPE specimens, and a strong association was observed between mRNA and protein expression (P = .00017). Moreover, higher TS levels were observed in high‐grade tumors (P = .0389 and P = .0068 for mRNA and protein quantification, respectively). The analysis in snap‐frozen samples revealed that the TS gene was up‐regulated strongly in tumors (P = 3.8 × 10−12), and an 8‐fold increase (as a cut‐off value) in the TS mRNA ratio between tumor and corresponding normal tissue was detected in 32 of 56 patients (57%) bearing preferentially squamous cell tumors (P = .0022) and high‐grade tumors (P < .001).CONCLUSIONS.Data from the current study consistently indicated higher TS expression levels in squamous cell and in high‐grade carcinomas. This information may be useful in selecting which patients with NSCLC should receive treatment with TS‐inhibiting agents. Cancer 2006. © 2006 American Cancer Society.
Gliomatosis cerebri: 20 Years of experience at the Children's Hospital of Philadelphia
Authors: Armstrong Gregory T. , Phillips Peter C. , Rorke‐Adams Lucy B. , Judkins Alexander R. , Localio A. Russell , Fisher Michael J. 
Published: September 2006

AbstractBACKGROUND.Gliomatosis cerebri (GC) is a rare and typically fatal glial neoplasm of the central nervous system. In this report, the authors describe the largest cohort of children to date with GC and explore relations between potential prognostic factors, treatment, and survival.METHODS.Imaging, pathologic, and outcome data were reviewed from 13 patients who were diagnosed with GC and were treated at the Children's Hospital of Philadelphia (CHOP) between 1982 and 2005. All patients had GC confirmed by biopsy. Twelve patients received cranial irradiation, and 8 of those patients received adjuvant chemotherapy. A single patient age 1 year received chemotherapy alone. A review of the literature identified 51 pediatric patients with GC.RESULTS.The progression‐free survival rate in this study was 13% (range, 1.5–43 months), and the overall survival (OS) rate was 64% (range, 6.5–67 months) at 2 years. OS was significantly shorter for patients who presented in the first decade of life (P = .04). The time to progression was prolonged significantly for patients who had no evidence of tumor enhancement on imaging studies (P = .03). When survival data from patients reported in the literature were combined with the CHOP cohort, treatment prolonged OS significantly (P = .003).CONCLUSIONS.The outcome of pediatric patients with GC was extremely poor; however, the current results indicated that treatment may prolong OS. Age < 10 years and contrast enhancement on magnetic resonance imaging studies at diagnosis may be risk factors for shorter survival in pediatric patients with GC. Cancer 2006. © 2006 American Cancer Society.
Asymmetry Induction by Cooperative Intermolecular Hydrogen Bonds in Surface‐Anchored Layers of Achiral Molecules
Authors: Dmitriev Alexandre , Spillmann Hannes , Stepanow Sebastian , Strunskus Thomas , Wöll Christof , Seitsonen Ari P. , Lingenfelder Magali , Lin Nian , Barth Johannes V. , Kern Klaus 
Published: September 2006

AbstractThe mesoscale induction of two‐dimensional supramolecular chirality (formation of 2D organic domains with a single handedness) was achieved by self‐assembly of 1,2,4‐benzenetricarboxylic (trimellitic) acid on a Cu(100) surface at elevated temperatures. The combination of spectroscopic [X‐ray photoelectron spectroscopy (XPS) and near‐edge X‐ray absorption fine structure (NEXAFS)], real‐space‐probe [scanning tunneling microscopy (STM)], and computational [density functional theory (DFT)] methods allows a comprehensive characterization of the obtained organic adlayers, where details of molecular adsorption geometry, intermolecular coupling, and surface chemical bonding are elucidated. The trimellitic acid species, comprising three functional carboxylic groups, form distinct stable mirror‐symmetric hydrogen‐bonded domains. The chiral ordering is associated with conformational restriction in the domains: molecules anchor to the substrate with an ortho carboxylate group, providing two para carboxylic acid moieties for collective lateral interweaving through H bonding, which induces a specific tilt of the molecular plane. The ease of molecular symmetry switching in domain formation makes homochiral‐signature propagation solely limited by the terrace width. The molecular layer modifies the morphology of the underlying copper substrate and induces μm‐sized strictly homochiral terraces.
Intravenous iron requirement in adult hemodialysis patients
Authors: Nguyen Timothy V. 
Published: September 2006

AbstractObjective.Chronic hemodialysis patients often require maintenance intravenous iron, as iron is an essential component of effective erythropoiesis. The Anemia Work Group (NKF‐K/DOQI) anemia guidelines suggest a maintenance intravenous iron dose of 25–125 mg, but the optimal maintenance dose regimen remains difficult to determine. K/DOQI recommends these iron parameters: TSAT ≥ 20% and < 50%, ferritin ≥ 100 and < 800 ng/mL. An assessment of the maintenance dose regimen used in the present study is presented in this article.Patients and Methods.Data were collected retrospectively to evaluate clinical response in 40 adult chronic hemodialysis patients who received regular maintenance intravenous iron sucrose of 100 mg either every other week or every fourth week based on their ferritin and transferrin saturation (TSAT) levels. If ferritin level was between 100 and 500 ng/mL and TSAT level was 20% and 30%, then iron sucrose was administered every other week; if ferritin was 500–700 ng/mL or TSAT was 30%–45%, then iron sucrose was administered every fourth week. Ferritin and TSAT levels were monitored quarterly.Results.After the first quarter, 15 (38%) of the patients (n=15) remained on their original dosing regimen; 21 (53%) patients required adjustment to their regimen, either by discontinuing the regimen (n = 18) or decreasing the dosing interval (n = 3), 45% and 7.5% respectively; and 4 (10%) patients required additional intravenous iron supplementation.Conclusion.Iron sucrose administered at a dosage of 100 mg on a maintenance regimen either every other week or every fourth week exceeded most patients' requirements. Maximum intravenous iron maintenance doses for adult chronic hemodialysis patients remain difficult to determine, and the maintenance iron requirement varies from patient to patient.
Dialysis facility design—part II: Minimize costly plan changes
Authors: Bower Steven B. 
Published: September 2006

AbstractDuring the development and construction of a dialysis clinic, there are decisions that influence the cost, building quality, and completion date of the project. Change orders—changes to the project after bidding and a contractor has been awarded—are often unavoidable. The owner, architect, and contractor, as well as outside agencies, will at times desire to make changes due to whim or necessity. Often, how you approach these changes has a larger impact on cost and schedule than the change itself. This article, the second of four installments focusing on dialysis clinic design, will review many of the issues that arise in successful project initiation and development from concept through construction, and will address several types of challenges that traditionally occur during the process.