bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rubella antibody levels in the healthy Chinese population:a meta-analysis
Authors: Zhuo Yaning , Lu Zhaojun , Zhang Xuechao , Zhang Xiaoping , Yang Yingying , Han Jiayin , Du Jian , Xu Yuyang , Liu Yan , Fu Chuanxi 
Published: April 2024

Abstract

Objectives
To gain a comprehensive understanding of rubella antibody levels in the healthy population in China and to offer data-driven support for the goal of rubella elimination.
Methods
CNKI, Wanfang database, VIP database, CBM, PubMed, web of Science, and Embase databases were searched to collect studies reporting the positive rate of rubella antibody among the Chinese healthy populations between 2001 and 2022. We conducted a meta-analysis using R language, and data were combined using random effects model.
Results
A total of 97 studies were included, encompassing a sample size of 103,018. Meta-analysis showed that the overall prevalence of rubella antibody positivity in the Chinese healthy population was 77.29% (95% CI: 75.26-79.33). The prevalence of rubella antibody varied significantly based on age and vaccination status. Among the age groups studied, the <1-year-old group exhibited the lowest positivity rate for rubella antibody at 47.87% (95% CI: 41.53-54.21),while the ≥50 years old group showed the highest positivity rate at 85.43% (95% CI: 81.01-89.85); individuals with a history of vaccination demonstrated a higher antibody positivity rate compared to those without vaccination history.
Conclusions
The prevalence of rubella antibody in healthy Chinese population is relatively low. In order to establish a solid immune barrier, it requires conducting timely immunization programs on key groups such as middle school students and the women of childbearing age on the basis of ensuring a high level of rubella-containing-vaccines (RCV) coverage, so as to achieve the goal of eliminating rubella.
Arsenic levels in the hair of people exposed to arsenic and awareness of its risk factors
Authors: Chen Xiangping , Liu Siyu , Shi Manman , Luo Yan 
Published: April 2024

Abstract

Arsenic is widely found in nature, and because of its carcinogenic properties, it has come to be a serious threat to human health. The effects of arsenic on the human body are influenced by a variety of factors, including the level of arsenic in external environmental pollutants and individual human factors. Therefore, the aim of this study was to assess the level of arsenic in populations living in arsenic-contaminated areas and the influencing factors. Environmental media samples (water and wheat) and biological samples (hair) were selected for arsenic analysis in both arsenic-contaminated and arsenic-safe areas. Socio-demographic information and behavioral characteristics information were obtained from questionnaires to analyze factors that cause an increase in arsenic levels in the body. In study area, 89.33% of the water samples exceeded the national standard (10 μg/L) and 2.13% of the wheat samples had arsenic concentrations above the safe limit (0.5 mg/kg). In contrast, arsenic levels in drinking water and wheat in the control area were within safe limits. A presence of 29 (29.29%) respondents with levels of arsenic in hair higher than 1 mg/kg was found in arsenic-contaminated areas. The results of the analysis showed a significant difference (P<0.05) in the level of arsenic in the hair of the inhabitants of arsenic-contaminated areas and those of arsenic-safe areas, with concentrations of 0.967 mg/kg and 0.392 mg/kg, respectively. Univariate comparative analysis of factors affecting body arsenic levels showed correlations between sex, age, years of residence, smoking, disease history, wheat-based food intake, and levels of arsenic in hair. Multiple linear regression analysis identified gender, age, and wheat-based food intake as risk factors for increased arsenic levels. The study of factors influencing the level of arsenic in the body can provide a scientific basis for the precise prevention and control of health problems resulting from environmental pollution.
Dynamics and drivers of tidal flat morphology in China
Authors: Hu Zhan , Liu Shuai , Grandjean Tim , Wang Zheng Bing , Zelst Vincent T. M. , Qi Lin , Xu Tianping , Seo Jun , Bouma Tjeerd 
Published: April 2024

Abstract
Recent remote sensing analysis has revealed extensive loss of tidal flats, yet the mechanisms driving these large-scale changes remain enigmatic. This study traces the spatiotemporal variations of 2538 tidal flat transects across China to elucidate how their morphological features vary with external factors, including suspended sediment concentration (SSC), tidal range, and wave height. We observe a correlation between flat width and SSC distribution, and between flat slope and tidal range. A national-wide decline in flat width is observed together with SSC reduction between 2002 and 2016. Intriguingly, sediment-rich flats exhibit a more rapid response to SSC reduction compared to sediment-starving areas, but the converse is observed with SSC increase. These conditional responses stem from the morphodynamic tendency towards equilibrium, which is well explained by synthetical modeling. This finding suggests that tidal flats are resilient to sediment supply reduction, and nation-scale sediment allocation can assist in preserving valuable intertidal areas.
Evolution of flood protection levels and flood vulnerability in Europe since 1950 estimated with vine-copula models
Authors: Paprotny Dominik , Hart Cornelis Marcel Pieter 't , Napoles Oswaldo Morales 
Published: April 2024

Abstract

The magnitude of flood losses is regulated not only by hydrometeorological hazard and exposure, but also flood protection levels (primarily from structural flood defenses) and vulnerability (relative loss at given intensity of hazard). Here, we infer the variation of both factors from data on historical riverine, coastal and compound floods and their impacts in 42 European countries over the period 1950–2020 obtained from the HANZE database. We contrast actual damaging floods, which imply flood protection was locally inadequate, with modelled potential floods, i.e. events that were hydrologically extreme but did not lead to significant impacts, which imply that flood protection was sufficient to prevent losses. Further, we compare the reported magnitude of impacts (fatalities, population affected, and economic losses) with potential impacts computed with a uniform, static approach. We finally derive the spatial and temporal drivers of both flood protection and vulnerability through a multivariate statistical analysis. We apply vine-copulas to derive the best predictors out of a long list of candidate variables, including hydrological parameters of floods, exposure to floods, socioeconomic development, and governance indicators. Our results show that flood protection improved since 1950, particularly for coastal floods. However, riverine protection levels are shown to be much lower than assumed in previous pan-European studies. A strong decline in flood vulnerability over time is also observed for all three indicators of relative losses, suggesting improved flood adaptation. However, there are very large variations in both flood protection and vulnerability between subnational regions in Europe.
Spatial Distribution Characteristics and Influencing Factors of Youth Soccer Specialty Schools in China
Authors: Zhou Yujin , Chen Qiuhuan , He Dong , Cheng Yu , Peng Xiaowei 
Published: April 2024

Abstract

Youth soccer specialty schools are the primary project to strengthen the foundation of soccer talents, improve the level of soccer development, and achieve the dream of Chinese soccer. Taking 32775 soccer specialty schools in China as the research sample, ArcGIS spatial analysis technology is used to explore the spatial distribution characteristics of specialty schools and their influencing factors. The analysis shows that the overall layout of the country forms eight high-density core areas, the overall spatial distribution is aggregated, and the degree of aggregation is high, with significant differences between east and west. The influencing factors of specialty schools include nine factors within four dimensions: historical development, geographic environment, socio-economy, and educational resources. It was found that geographic environment and socio-economy provide the foundation and background for developing educational resources. However, the direct role of educational resources is more significant in a specific educational program, such as specialty schools, followed by socio-economy and geographic environment. This study provides a comprehensive analysis and interpretation of specialty schools' spatial distribution characteristics and influencing factors. These results enrich the research on the spatial layout of sports, providing necessary theoretical support and practical references for the layout and high-quality development of related industries in China and other countries or regions.
Cytotoxicity and cell migration evaluation of a strontium silicate-based root canal sealer on stem cells from rat apical papilla: An in vitro study
Authors: Zhou Guanglei , Zhao Yu , Cai Liangjing , Liu Liwei , Li Xu , Sun Lu , Deng Jiayin 
Published: April 2024

Abstract

BACKGROUND
Bioceramic materials,a new biomaterial formulation in which strontium is introduced into a bioceramic sealer,have been widely used as root canal sealers in the clinic.
OBJECTIVE
This study aimed to evaluate the cytotoxicity and cell migration effects of a novel strontium silicate-based bioceramic material (CRoot SP) in comparison with those of a calcium silicate-based sealer (iRoot SP) and epoxide amine resin sealer (AH Plus) on stem cells from rat apical papilla(rSCAPs).
METHODS
The rSCAPs were isolated and characterized in vitro, then cultured with various concentrations of CRoot SP, iRoot SP and AH Plus extract. Cytotoxicity was assessed by CCK-8 assay and wound healing assays were performed to evaluate cell-migration capacity.
RESULTS
No significant differences in cell viability were observed among the 0.02 mg/mL; and 0.2 mg/mL sealer groups.The cell viability of CRoot SP was consistently greater than that of iRoot SP at concentrations of 5 mg/mL and 10 mg/mL across all time points. The maximum cytotoxic effect was noted on day 5 with 10 mg/mL AH Plus.The scratch has been partly healed with cell migration in all groups at 24 h, the 0.02 mg/mL, and 0.2 mg/mL CRoot SP have beneficial effects on rSCAPs migration.
CONCLUSIONS
CRoot SP is less cytotoxic than the iRoot SP and AH Plus extracts after setting. A lower concentration of CRoot SP enhances the cell migration capacity of rSCAPs, and CRoot SP may achieve better tissue repair during root canal treatment.
Radioprotective properties of the kombucha-derived bacterial cellulose
Authors: Kołodziejczyk Agata Maria , Silarski Michał , Kaczmarek Mateusz , Harasymczuk Matt , Dziedzic-Kocurek Katarzyna , Uhl Tadeusz 
Published: April 2024

Abstract

Living organisms are constantly exposed to cosmic, terrestrial, and internal sources of radiation. As a result, they have developed natural radioprotective mechanisms. However, in some cases, these mechanisms may not be sufficient. Elevated doses and prolonged exposure to radiation, such as during radiotherapy or in extreme environments like spaceflight, can cause damage to DNA and reactive oxygen species, which can affect biological processes. In contrast to synthetic ingredients, naturally produced radioprotective materials have good biocompatibility and are easy to recycle. This work investigates the radioprotective properties of the hydrogel biofilm produced by the kombucha microbial consortium. The main product, cellulose, is synthesized by acidic bacteria. The radiation protection properties of kombucha's bacterial cellulose (KBC) were examined using gamma quanta with energies ranging from 122 to 1408 keV and an AmBe neutron source. The native form of KBC contains more than 80% water content. To enhance the radioprotection of kombucha's biofilm, metallic components (K, Fe, Mxenes) and biological additives were tested. Rhodobacter sphaeroides and Synechocystis sp. PCC6803, which are resistant to oxidative stress, were added to the cultivation media. The chemical composition of the resulting KBC films was measured using the FTIR method. Physical properties were characterized using microscopy, ion leaching, and contact angle measurements. Post-processed dried KBC wristbands were analyzed for absorption parameters to enhance protective shielding. Possible levels of radioprotection for various types of bacterial cellulose thickness and forms were computed based on the obtained results. The findings encourage the use of bacterial cellulose in a circular economy for future bioregenerative processes.
Mid-Facial Skeletal and Soft Tissue Changes After Maxillary Skeletal Expander Application: A CBCT Study
Authors: ALAN Arzu , KAYA Yeşim , SANCAK Kevser 
Published: April 2024

Abstract

Introduction:
The increased resistance of midpalatal, zygomaticomaxillary and pterygopalatine sutures overtime, reduces the dentofacial orthopedic effect of conventional expanders. To adress this, mini-screw-assisted rapid palatal expanders have been created. The aim of this study was to investigate the mid-facial soft tissue changes along with rotational movements of zygomaticomaxillary complex after maxillary skeletal expander(MSE) application.
Materials and Methods
Pre- and post-expansion CBCT images of 17 patients(10 female,7 male) with transversal maxillary deficiency and treated with MSE 2, were enrolled in this retrospective study. Eight skeletal angular measurements were performed in the coronal and axial zygomatic sections. Besides, nineteen linear and 3 angular soft tissue measurements were investigated in the midsagittal plane. All the measuments were performed using OnDemand3D software(CyberMed Inc,Seoul,Korea). Paired-t test was used to compare the pre- and post-expansion outcomes.
Results
In the coronal zygomatic section, the decrease in frontoethmoidal angle and increases in frontozygomatic and zygomaticomaxillary angles revealed the outward rotation of zygomaticomaxillary comples. The increase in maxillary inclination showed the downward rotation of zygomaticomaxillary complex. The increases in frontozygomatic, frontoalveolar and frontodental angles represented greater skeletal expansion and minimal alveolar bone bending and dental tipping. The soft tissue measurements revelaed significant increase in the upper and lower face heights, alar nasal width, nasal tip protrusion, vertical filtrum height, and nasal width angle and a decrease in the facial profile angle.
Conclusion
Downward and outward rotation of the zygomaticomaxillary complex around the fulcrum area above the superior aspect of the frontozygomatic suture caused significant soft tissue changes in the paranal and nasal area.
Experimental investigation on the macro- and micromechanical properties of water-cooled granite at different high temperatures
Authors: Wang Tianzuo , Wang Jisha , Zhang Xin , Cheng Peifeng , Xue Fei , Xue Mengya , Li Zheng 
Published: April 2024

Abstract

To investigate the influence of high-temperature and water-cooling treatments on the macro and micro-mechanical properties of granite, uniaxial compression tests were conducted on the treated samples using the MTS815.04 testing system. Simultaneously, acoustic emission signals were collected, and micro-mechanical experiments were performed using a nanoindenter for further analysis. The results revealed that (1) with increasing temperature, the peak strength and elastic modulus of granite decreased, leading to a deterioration in mechanical properties, with a pronounced degradation trend observed after 400–500 ℃. (2) The ringing count of acoustic emission exhibited a similar trend over time within the range of 25–400 ℃, with an increasing proportion of active period I and a decreasing quiet period. The quiet period disappeared at 500 ℃, indicating a significant increase in the influence of high temperature and rapid cooling on internal rock damage beyond 500 ℃. (3) When the temperature is below 500 ℃, the slow decline in the macroscopic mechanical properties of granite is attributed to the differences in the thermophysical properties and content of minerals. However, the rapid decline in the microscopic mechanical properties of the minerals and the generation and propagation of microcracks may be the primary factors contributing to the deterioration of the macroscopic mechanical properties of granite above 500 ℃. (4) The water-cooled granite's uniaxial damage mode changed from tensile damage to tensile‒shear composite damage at 400 ℃ and finally to shear damage at 800 ℃.
Characterizing the linkage of systemic hypoxia and angiogenesis in high grade glioma to define the changes in tumor microenvironment for predicting prognosis
Authors: Shrivastava Richa , Gandhi Puneet , Sorte Sandeep K , Shrivastava Adesh 
Published: April 2024

Abstract

Background
High-grade gliomas (HGG) comprising WHO-grades 3and4 have a poor overall-survival (OS) that has not improved in the past decade. Herein, markers representing four-components of the tumor-microenvironment(TME) were identified to define their linked expression in TME and predict the prognosis in HGG, namely, Interleukin6(IL6,inflammation), inducible nitrous-synthase(iNOS), heat-shock protein-70(HSP70,hypoxia), vascular-endothelial growth-receptor(VEGF) and Endothelin1(ET1)(angiogenesis) and Matrix metalloprotease-14(MMP14) and intercellular-adhesion molecule1(ICAM1,extracellular-matrix).
Objective
To establish a non invasive panel of biomarkers for precise prognostication in HGG
Material and methods
86 therapy-naive HGG patients with 45 controls were analysed for the defined panel. Systemic-expression of extracellular/secretory biomarkers was screened dot-immune-assay(DIA), quantified by ELISA and validated by Immunocytochemistry(ICC).
Results
Expression of iNOS, HSP70, IL-6, VEGF, ET1, MMP14, ICAM1 was found to be positively associated with grade. Quantification of circulating levels of the markers by ELISA and ICC presented a similar result. The biomarkers were observed to negatively correlate with OS (p < 0.0001). Cox-regression analysis yielded all biomarkers as good prognostic-indicators; independent of confounders. On applying combination-statistics, the biomarker-panel achieved higher sensitivity than single markers to define survival. The intra-association of all seven-biomarkers was significant, hinting of a crosstalk between the TME components and a hypoxia driven systemic inflammation up-regulating the expression of other components.
Conclusion
This is a first-ever experimental-study of a marker-panel that can distinguish between histopathological-grades, and also delineate differential-survival using liquid-biopsy, suggesting that markers of hypoxia can be a cornerstone for personalized-therapy. The panel of biomarkers of iNOS, HSP70, IL-6, VEGF, ET1, MMP14 and ICAM1 holds promise for prognostication in HGG.
Protection of Guizhou Miao Batik Culture Based on Knowledge Graph and Deep Learning
Authors: Quan Huafeng , Li Yiting , Liu Dashuai , Zhou Yue 
Published: April 2024

Abstract

In the globalization trend, China's cultural heritage is in danger of gradually disappearing. The protection and inheritance of these precious cultural resources has become a critical task. This paper focuses on the Miao batik culture in Guizhou Province, China, and explores the application of knowledge graphs, natural language processing, and deep learning techniques in the promotion and protection of batik culture. We propose a dual-channel mechanism that integrates semantic and visual information, aiming to connect batik pattern features with cultural connotations. First, we use natural language processing techniques to automatically extract batik-related entities and relationships from the literature, and construct and visualize a structured batik pattern knowledge graph. Based on this knowledge graph, users can textually search and understand the images, meanings, taboos, and other cultural information of specific patterns. Second, for the batik pattern classification, we propose an improved ResNet34 model. By embedding average pooling and convolutional operations into the residual blocks and introducing long-range residual connections, the classification performance is enhanced. By inputting pattern images into this model, their subjects can be accurately identified, and then the underlying cultural connotations can be understood. Experimental results show that our model outperforms other mainstream models in evaluation metrics such as accuracy, precision, recall, and F1-score, achieving 99.0%, 99.0%, 98.9%, and 99.0%, respectively. This research provides new ideas for the digital protection of batik culture and demonstrates the great potential of artificial intelligence technology in cultural heritage protection.
Different impact of anastomotic leak on long-term recurrence after surgery for rectal vs colonic cancer A systemic review and meta-analysis
Authors: Zhu Feng , Feng Dengyu , Yu Zeqian , Gong Jianfeng 
Published: April 2024

Abstract

Background
Long-term recurrence after resection for colorectal cancer (CRC) might be influenced by anastomotic leak (AL). Recent studies investigating this topic have reported discrepant findings.
Materials:
Studies investigating the impact of AL on long-term oncological outcomes after CRC resection were identified from the electronic databases to perform meta-analysis. Meta-regression and subgroup analyses were performed to identify and adjust for cofounders.
Results
Seventy-two studies comprising 153,828 subjects were enrolled. Meta-analysis showed AL was associated with an increased local recurrence (LR) in rectal cancer (HR 1.63 95% CI 1.26–2.11, p = 0.002) but not colonic cancer (HR 1.61 95% CI 0.34–7.57, p = 0.271). In contrast, AL was associated with an increased distant recurrence (DR) in colonic cancer (HR 1.45 95% CI 1.16–1.81, p = 0.005) but not rectal cancer (HR 1.03 95% CI 0.74–1.43, p = 0.374). Subgroup analysis of studies with > 50% of patients receiving neoadjuvant chemoradiotherapy (CRT) (LR: p = 0.055, DR: p = 0.127) showed no significant relationship between AL and recurrence. Re-operated (OR 1.73 95% CI 1.03–2.92, p = 0.038) but not conservatively treated AL (OR 1.05 95% CI 0.54–2.06, p = 0.886) increased LR. AL was associated with decreased survival in CRC patients.
Conclusion
After AL, rectal cancer had distinct recurrence pattern than colonic cancer while long-term survival rate was generally decreased. The impact of AL on oncological outcome tends to be influenced by the severity of AL and the application of neoadjuvant chemoradiotherapy.