bluuebunny/crossref_metadata_2025_split huggingface dataset:
Method for calculating the strength of massive structural elements in the general case of their stress-strain state (kinematic method)
Authors: Новоселов О.Г. , Сабитов Л.С. , Сибгатуллин К.Э. , Сибгатуллин Э.С. , Клюев А.В. , Клюев С.В. , Шорстова Е.С. 
Published: March 2024

предложен вариант кинематического метода теории предельного равновесия; рассматриваются массивные элементы конструкций, материал которых, в общем случае, анизотропный. Принята жесткопластическая модель деформируемого твердого тела. Принято допущение, что массивные элементы конструкций разрушаются путем разделения на части, которые относительно мало деформируются («абсолютно жесткие конечные элементы»,АЖКЭ) и имеют 6 степенней свободы в трехмерном пространстве. Процесс разрушения материала идет по бесконечно тонким обобщенным поверхностям разрушения (ОПР), на которых учитывается работа всех действующих внутренних силовых факторов (ВСФ) – 9-ти сил и 9-ти моментов. Рассмотрены тела из однородных изотропных материалов, сопротивляющихся по-разному растяжению и сжатию. Поверхности прочности в пространстве ВСФ описываются соответствующими параметрическими уравнениями. С использованием уравнения равновесия в форме Лагранжа и принципа максимума Мизеса, а также предложенных параметрических уравнений предельной поверхности, задача определения минимального значения параметра кинематический возможной нагрузки сведена к стандартной задаче линейного программирования (ЛП), которая решается с использованием симплекс-метода.
Abstract: a variant of the kinematic method of the theory of limit equilibrium is proposed; massive structural elements are considered, the material of which, in the general case, is anisotropic. A rigid-plastic model of a deformable solid body is adopted. It is assumed that massive structural elements are destroyed by dividing into parts that deform relatively little (“absolutely rigid finite elements”, ARFE) and have 6 degrees of freedom in three-dimensional space. The process of destruction of the material goes along infinitely thin generalized destruction surfaces (GDS), on which the work of all acting internal force factors (IFF) is taken into account – 9 forces and 9 moments. Bodies made of homogeneous isotropic materials that resist tension and compression in different ways are considered. The strength surfaces in the IFF space are described by the corresponding parametric equations. Using the equilibrium equation in the Lagrange form and the Mises maximum principle, as well as the proposed parametric equations of the limiting surface, the problem of determining the minimum value of the possible kinematic parameter of the load is reduced to a standard linear programming problem (LP), which is solved using the simplex method.
Reflections
Authors: Quain David 
Published: March 2024

This issue of Reflections recognises the hardy group of peer reviewers that support and drive the publication of papers in the Journal. It’s a hackneyed expression but these folk do make a difference. They deserve our huge thanks. As the first issue of the year, it is also ‘numbers’ time looking back at the metrics for the first year of the ‘new’ JIB. The publications in 2023 came from ten countries demonstrating the global nature of research into malting, brewing and distilling. Google Analytics shows there were nigh on 5000 visitors to the Journal website, from 111 countries with 29% originating from the USA, 27% from the UK, 13% from China and 7% from Germany. Of the 16 papers, four editorials and one letter to the Editor there were > 11,000 views of abstracts and > 6,100 downloads of pdfs. Finally, there is an update on the KPIs that track the time for steps in the process and compares them with 2023.
Early outcomes of fenestrated and/or branched endovascular repair of complex aortic aneurysms (F/B-EVAR); A single-center experience
Authors: Tzimkas-Dakis Konstantinos , Matsagkas Miltiadis , Kouvelos George , Spanos Konstantinos , Bareka Metaxia , Chaidoulis Athanasios , Arnaoutoglou Eleni , Giannoukas Athanasios 
Published: March 2024

Background: Open surgical repair of juxta-, para- and thoracoabdominal aortic aneurysms (TAAA) has been the gold-standard for patients fit for surgery. However, endovascular repair of complex aortic aneurysms using devices implementing directional branches or fenestrations for incorporation of reno-visceral target vessels (TV) has gained widespread attention, due to its lower mortality and complication rate and its more attractive profile for high-risk patients. Nonetheless, complex endovascular technologies require meticulous abidance to protocols for successful application.
Methods: A retrospective analysis of prospectively collected data from a single, tertiary center was undertaken, including all patients undergoing complex aortic endovascular repair with fenestrated (F-EVAR) of branched devices (B-EVAR) from a 5-year time period (2018-2023). Primary outcomes included 30-day mortality, while secondary outcomes included primary TV patency, acute kidney injury (AKI), spinal cord ischemia (SCI), myocardial infarction (MI) and stroke rates.
Results: Of 74 patients (mean age: 69 ± 5.6 years-old, 98% males), 31 (42.6) and 43 (57.6%) were treated by F-EVAR and B-EVAR, respectively. Mean aneurysm diameter was 68 ± 1.8cm, with 15 (20.5%) juxtarenal AAA, 27 (35.6%) pararenal AAA, 16 (21.9%) type IV TAAA, 6 (8.2%) type III TAAA, and 10 (13.7%) type II TAAA treated. Sixteen (21.6%) patients were treated due to failed-EVAR. In total, 272 TV were successfully revascularized. Thirty-day mortality was 8.1%. Primary TV patency rate was 99.2% (270/272). Endoleak rate was 8.1% (6/74). No cases of AKI or MI were observed. One (1.3%) case of hemorrhagic stroke was observed. Three cases (4%) of SCI were observed, including one temporary paraparesis and two permanent paraplegia cases. Reintervention rate was 5.4%, including two cases of renal artery stent thrombosis revascularization procedures.
Conclusions: Endovascular repair of complex aortic aneurysms is feasible, with good perioperative outcomes. Adherence to precise protocols covering every technical aspect of patient care is warranted for satisfactory outcomes.
Evolution of Islamic Education Teachers' Competence in Indonesia
Authors: Siregar Zulfikar Ali Buto , . Jarudin 
Published: March 2024

This research aims to outline a study that examines the historical development, current status, and future direction of Islamic education teacher competency in the Indonesian context. Using a qualitative method approach from interviews with educators, policymakers, and academics. This report highlights the role of government initiatives and Islamic education institutions in improving teacher competency, focusing on areas such as pedagogical skills, subject matter expertise, and the integration of information and communications technology (ICT) in teaching. The results of the research show that teachers must reflect uswah alhasanah, teachers do good deeds, have an educational orientation to worship for Allah, have a clear mind in daily life, have a pure heart, master in-depth religious knowledge (ulumuddiniyah), have the ability to educate intellectually (tarbiatul aqliyah), have the ability to educate the heart (tarbiyatul qulubiyah), have the ability to educate character (tarbiyatul khulukiyah), have the ability to educate physically (tarbiyatul jismiyah) and have the ability to educate socially (tarbiyatul ijtimaiyah). These findings indicate that although significant progress has been made in improving the competency of Islamic education teachers in Indonesia, continued efforts are needed to address emerging challenges and to ensure that teachers are equipped to provide high-quality, relevant, and inclusive education. This research contributes to the broader discourse regarding teacher competency in Islamic education, offering relevant insights for educators, policymakers, scholars, and stakeholders involved in religious education globally.
PENGARUH TRUST TERHADAP KINERJA KARYAWAN DENGAN ETIKA KERJA ISLAM SEBAGAI VARIABEL MODERATING
Authors: Arbaan  , Manyur Addury Multazam 
Published: March 2024

Penelitian ini bertujuan untuk meneliti pengaruh trust terhadap kinerja karyawan menggunakan etika kerja islami sebagai variabel moderator. Penelitian ini dilakukan pada karyawan lembaga keuangan syariah di Yogyakarta. Sampel dalam penelitian ini adalah karyawan yang bekerja pada lembaga keuangan syariah di Daerah Istimewa Yogyakarta dengan jumlah 70 orang responden. Teknik analisis data untuk mengetahui pengaruh trust terhadap kinerja dengan etika kerja Islam sebagai variabel moderasi adalah dengan menggunakan analisis hipotesis dengan metode MRA (Moderate Regrestion Analysis) yang kemudian akan diketahui hasilnya. Berdasarkan analisis hipotesis dengan metode MRA (Moderate Regrestion Analysis) dalam penelitian ini, telah diperoleh hasil bahwa variabel trust memiliki pengaruh sebesar 70,9% terhadap variabel kinerja sebelum dimoderasi variabel etika kerja Islam dan sisanya atau sebesar 29,1% dipengaruhi oleh variabel lain. Setelah dimoderasi oleh variabel etika kerja Islam, pengaruh hubungan variabel trust terhadap variabel kinerja meningkat menjadi 74,2% dan bernilai positif dengan signifikansi sebesar 0,034, sisanya sebesar 25,8% dipengaruhi oleh variabel lain. Dengan demikian, maka dapat disimpulkan bahwa variabel moderasi pada penelitian ini (etika kerja Islam) berperan sebagai penguat hubungan antara variabel independen (trust) dengan variabel dependen (kinerja).
Pemberdayaan Petani Melalui Program Reboisasi Penanaman Tanaman Keras. di Desa Giricahyo, Panggang, Gunung Kidul Yogyakarta
Authors: Istiqomawati Rina , Widiyastuti Andriyani , Priyono Susilo 
Published: March 2024

Perbukitan daearah gunung kidul adalah kawasan yang rawan longsor. Hal ini perlu di adakan upaya dalam penanggulangan tanah longsor tersebut, diantaranya adalah reboisasi/ penghijauan dengan tanaman keras. Tanaman keras selain untuk penghijauan juga bisa untuk keindahan dan bisa untuk mengurangi terjadinya tanah longsor. Tanaman keras itu diantaranya adalah : akasia , sengon laut, jambu mete, alpukat. Program penghijauan yang dilakukan di Gunung Kidul itu melibatkann bergabai pihak diantaranya adalah, pemerintah, STEI Yogyakarta dan warga sekitar khususnya petani. Penghijauan yang dilaksanakan itu selain menambah keindahan, penanggulangan tanah longsor juga bisa memberikan manfaat peningkatan ekonomis bagi warga sekitar khususnya petani. Potensi masyarakat dan sumberdaya petani di desa Giri cahyo, Kecamatan Panggang , kabupaten Gunung Kidul perlu disikapi dengan suatu pelatihan yang melibatkan Petani dalam memanfaatkan dan mengelola lingkungan sekitar melalui budidaya aneka jenis tanaman . Pelatihan dalam kegiatan pengabdian pada masyarakat ini ini bertujuan untuk: (1) Meningkatkan pengetahuan Petani di desa Giri cahyo tentang Tanaman keras yang bermanfaat dbagi peningkatan ekonomi, dan (2) Memberdayakan petani dalam pemanfaatan sumberdaya perdesaan berupa budidaya Tanaman Keras dan tanaman lainnya.
Kegiatan pengabdian dilakukan dengan metode ceramah dan demonstrasi. Metode ceramah untuk menjelaskan tentang kajian sumberdaya perdesaan, pemanfaatan sumberdaya perdesaan berupa tanaman Keras dan Tanaman lain. Pemberdayaan petani dalam budidaya Tanaman keras dan yang dapat mencegah erosi dan tanah longsor dan mempunyai nilai jual ekonomis. Metode demonstrasi juga dilakukan untuk mempraktekkan tata cara bertanam, memelihara, dan mengelola Tanaman Keras.
Kegiatan pengabdian masyarakat ini secara keseluruhan dapat dikatakan baik dan berhasil, dilihat dari keberhasilan target jumlah peserta pelatihan (100 persen), ketercapaian tujuan pelatihan (75 persen), ketercapaian target materi yang telah direncanakan (80 persen), dan kemampuan peserta dalam penguasaan materi (75 persen).
Proses Pembuatan Pupuk Organik Padat (POP) Kotoran Kambing dengan metode Fermentasi di desa Giriasih, Purwosari Gunung Kidul
Authors: Widianti Emma 
Published: March 2024

Pertanian organik merupakan sistem pertanian yang pada mulanya digalakkan setelah terdapat dampak-dampak negatif yang timbul akibat pelaksanaan revolusi hijau dengan memanfaatkan masukan (input) berbahan kimia yang menimbulkan beberapa dampak negatif yaitu kerusakan lingkungan, cemaran residu kimia, penurunan keanekaragaman hayati, penurunan produktivitas, dan kemunduran kesuburan lahan. Pupuk organik merupakan pupuk yang berasal dari berbagai bahan pembuat pupuk alami seperti kotoran hewan, bagian tubuh hewan, tumbuhan, yang kaya akan mineral serta baik untuk pemanfaatan penyuburan tanah.
Hasil dari kegiatan pelatihan pembuatan pupuk organik padat yaitu edukasi petani tentang proses fermentasi pada pupuk kotoran kambing dalam menguraikan bahan-bahan organik yang terkandung dalam kotoran kambing untuk dijadikan sebagai sumber unsur-unsur hara yang stabil dan lebih mudah diserap oleh tanaman daripada pupuk organik yang tidak difermentasi, dapat menjadikan tanaman tumbuh lebih subur serta proses partumbuhan dan perkembangannya juga lebih cepat serta menambah nilai manfaat ekonomis bagi masyarakat setempat
Pembinaan dan Pemberdayaan Pembatik Desa Girirejo Imogiri Bantul, Membangun Kembali Industri Batik Desa Girirejo Imogiri Bantul D.I. Yogyakarta
Authors: Baskoro Windu , Widiastuti Andriyani 
Published: March 2024

Desa Girirejo, Imogiri, Bantul merupakan sebuah desa yang dulunya merupakan sentra industri Batik di Yogyakarta (1960 – 1980), namun masih memiliki pembatik dan peralatan yang masih berpotensi untuk dihidupkan dan kembangkan kembali. Tujuan pengabdian masyarakat ini adalah menghidupkan kembali industri batik di desa Girirejo. Program Pengabdian menggunakan pendekatan atau Metoda PRA (Participatory Rural Appraisal). Beberapa teknik dan kegiatan dalam PRA antara lain, FGD (Focus Discussion Group), pemetaan sumber daya, workshop pembatikan serta evaluasi kinerja. Hasil dari Pengabdian masyarakat 1) Kesepakatan tim pengabdian, pembatik dan pemerintah desa untuk menghidupkan kembali industri batik , 2) Mendokumentasikan 45 alat cap batik dan merehabilitasi 3) Mendokumentasikan 25 motif batik tulis klasik dan merekonstruksi 4 motif batk tulis, 4) Workshop pembatikan selama 2 hari, tentang design motif batik tulis dan cap dan pewarnaan alami dan sintetis. Hasil program pengabdian ini telah memberikan pondasi awal untuk menghidupkan kembali industri batik di desa Girirejo, Imogiri Bantul yang perlu ditindaklanjuti dengan program penguatan
Anti-ENO1 antibody combined with metformin against tumor resistance: a novel antibody-based platform
Authors: Shu Xiong , Zhang Hui Wen , Liu Shi Ya , Sun Li Xin , Zhang Tao , Ran Yu Liang 
Published: March 2024

Background
Antibody-based platforms (i.e., ADC) have emerged as one of the most encouraging tools for the cancer resistance caused by cancer stem cells (CSCs) enrichment. Our study might provide a promising therapeutic direction against drug resistance and serve as a potential precursor platform for screening ADC.

Methods
The cell migration, invasion, drug resistance, and self-renewal were assessed by the cell invasion and migration assay, wound healing assay, CCK-8 assay, colony formation assay, and sphere formation assay, respectively. The expression profiles of CSCs (ALDH+ and CD44+) subpopulations were screened by flow cytometry. The western blot and cell immunofluorescence assay were used to evaluate pathway-related protein expression in both anti-ENO1 antibody, MET combined with DPP/CTX-treated CSCs.

Results
In the present study, western blot and flow cytometry verified that anti-ENO1 antibody target the CD44+ subpopulation by inhibiting the PI3K/AKT pathway, while metformin might target the ALDH+ subpopulation through activation of the AMPK pathway and thus reverse drug resistance to varying degrees. Subsequently, in vitro investigation indicated that anti-ENO1 antibody, metformin combined with cisplatin/cetuximab could simultaneously target ALDH+ and CD44+ subpopulations. The combination also inhibited the CSCs proliferation, migration, invasion, and sphere formation; which may result in overcoming the drug resistance. Then, molecular mechanism exploration verified that the anti-ENO1 antibody, metformin combined with cisplatin/cetuximab inhibited the Wnt/β-catenin signaling.

Conclusions
The study preliminarily revealed anti-ENO1 antibody combined with metformin could overcome drug resistance against CSCs by inhibiting the Wnt//β-catenin pathway and might serve as a potential precursor platform for screening ADC. More importantly, it is reasonably believed that antibody-based drug combination therapy might function as an encouraging tool for oncotherapy.
Occupation and adult‐onset asthma among chinese women in a population‐based cohort
Authors: Krstev Srmena , Ji Bu‐Tian , Shu Xiao‐Ou , Blair Aaron , Zheng Wei , Lubin Jay , Vermeulen Roel , Hauptmann Michael , Rothman Nathaniel , Gao Yu‐Tang , Mustafa Dosemeci , Chow Wong‐Ho 
Published: February 2007

AbstractBackgroundExposure to industrial irritants is believed to have contributed to the increasing prevalence of asthma worldwide. We examined the associations between occupation and asthma among women in a case‐control study nested in the population‐based Shanghai Women's Health Study cohort in China.MethodsCases were 1,050 women who reported a physician‐diagnosed asthma as adults. Controls were 4,200 women matched to the cases by year of birth and age at diagnosis. Lifetime occupational histories were obtained. Logistic regression was applied to estimate odds ratios (ORs) adjusting for smoking, education, family income, and concurrent chronic bronchitis.ResultsAsthma is more prevalent in production industries for metal tools (OR = 2.4; 1.3–4.7), metal products for everyday use (OR = 1.6; 1.1–2.4), ships (OR = 2.6; 1.0–6.8), and clocks (OR = 1.9; 1.0–3.4), and in occupations as farm workers (OR = 4.0; 1.2–13.0), laboratory technicians and analyzers (OR = 2.2; 1.2‐3.9), and installation and maintenance workers for weaving and knitting machineries (OR = 2.4; 1.1–5.4). Other associations less commonly reported were identified for electricians (OR = 2.1; 1.1–4.1), performers (OR = 3.2; 1.4–7.4), administrative workers in organizations and enterprises (OR = 1.8; 1.1–2.8), and postal and telecommunication workers (OR = 3.5; 1.6–7.6).ConclusionsOur findings suggest that occupational exposures contribute to the development of asthma in women. Am. J. Ind. Med. 2007. © 2007 Wiley‐Liss, Inc.
Survivin expression is associated with bladder cancer presence, stage, progression, and mortality
Authors: Shariat Shahrokh F. , Ashfaq Raheela , Karakiewicz Pierre I. , Saeedi Osamah , Sagalowsky Arthur I. , Lotan Yair 
Published: February 2007

AbstractBACKGROUNDThe purpose was to compare the differential expression of Survivin in normal bladder tissue, bladder transitional cell carcinoma (TCC) of different stages, and to determine whether expression of Survivin is associated with TCC clinical outcomes.METHODSImmunohistochemical staining for Survivin was carried out on archival bladder specimens from 9 normal controls and 222 consecutive patients who underwent radical cystectomy and bilateral lymphadenectomy. Lymph node tissue involved with TCC from 50 of the 222 cystectomy patients was also evaluated.RESULTSSurvivin was expressed in none of the normal bladder specimens, 64% of the cystectomy specimens, and 94% of the malignant lymph nodes. Multivariable analyses performed in the cystectomy patients revealed that Survivin expression was associated with disease recurrence (P = .040), disease‐specific mortality (P = .037), and all‐cause mortality (P = .044).CONCLUSIONSThe findings of the study provide a rationale for further evaluation of Survivin and its downstream signaling pathways in bladder cancer and raise the potential for Survivin‐targeted therapy for bladder cancer. Cancer 2007. © 2007 American Cancer Society.
Obesity is associated with increased risks of prostate cancer metastasis and death after initial cancer diagnosis in middle‐aged men
Authors: Gong Zhihong , Agalliu Ilir , Lin Daniel W. , Stanford Janet L. , Kristal Alan R. 
Published: February 2007

AbstractBACKGROUNDCurrent research is inconclusive regarding the effect of obesity on outcomes after a prostate cancer diagnosis. The objective of this study was to examine associations between obesity and the risks of developing metastasis or prostate cancer‐specific mortality in a population‐based cohort of men with prostate cancer.METHODSSeven hundred fifty‐two middle‐aged men with prostate cancer who were enrolled in a case‐control study and remain under long‐term follow‐up for disease progression and mortality formed the study cohort. Body mass index (BMI) in the year before diagnosis was obtained at the time of initial interview. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) of prostate cancer metastasis and mortality associated with obesity, controlling for age, race, smoking status, Gleason score, stage at diagnosis, diagnostic prostate‐specific antigen level, and primary treatment.RESULTSObesity (BMI ≥30 kg/m2) was associated with a significant increase in prostate cancer mortality (HR, 2.64; 95% CI, 1.18–5.92). Among men who were diagnosed with local‐ or regional‐stage disease, obesity also was associated with an increased risk of developing metastasis (HR, 3.61; 95% CI, 1.73–7.51). Associations generally were consistent across strata defined by Gleason score (2–6 or 7 [3 + 4] vs 7 [4 + 3] or 8–10), stage (local vs regional/distant for mortality), and primary treatment (androgen‐deprivation therapy use: yes vs no).CONCLUSIONSObesity at the time of diagnosis was associated with increased risks of prostate cancer metastasis and death. The increased risk of prostate cancer death or metastasis associated with obesity largely was independent of key clinical prognostic factors at diagnosis. Cancer 2007. © 2007 American Cancer Society.
Neurotrophic effects of GM1 ganglioside and electrical stimulation on cochlear spiral ganglion neurons in cats deafened as neonates
Authors: Leake Patricia A. , Hradek Gary T. , Vollmer Maike , Rebscher Stephen J. 
Published: February 2007

AbstractPrevious studies have shown that electrical stimulation of the cochlea by a cochlear implant promotes increased survival of spiral ganglion (SG) neurons in animals deafened early in life (Leake et al. [1999] J Comp Neurol 412:543–562). However, electrical stimulation only partially prevents SG degeneration after deafening and other neurotrophic agents that may be used along with an implant are of great interest. GM1 ganglioside is a glycosphingolipid that has been reported to be beneficial in treating stroke, spinal cord injuries, and Alzheimer's disease. GM1 activates trkB signaling and potentiates neurotrophins, and exogenous administration of GM1 has been shown to reduce SG degeneration after hearing loss. In the present study, animals were deafened as neonates and received daily injections of GM1, beginning either at birth or after animals were deafened and continuing until the time of cochlear implantation. GM1‐treated and deafened control groups were examined at 7–8 weeks of age; additional GM1 and no‐GM1 deafened control groups received a cochlear implant at 7–8 weeks of age and at least 6 months of unilateral electrical stimulation. Electrical stimulation elicited a significant trophic effect in both the GM1 group and the no‐GM1 group as compared to the contralateral, nonstimulated ears. The results also demonstrated a modest initial improvement in SG density with GM1 treatment, which was maintained by and additive with the trophic effect of subsequent electrical stimulation. However, in the deafened ears contralateral to the implant SG soma size was severely reduced several months after withdrawal of GM1 in the absence of electrical activation. J. Comp. Neurol. 501:837–853, 2007. © 2007 Wiley‐Liss, Inc.