bluuebunny/crossref_metadata_2025_split huggingface dataset:
CSST large-scale structure analysis pipeline: I. Constructing reference mock galaxy redshift surveys
Authors: Gu Yizhou , Yang Xiaohu , Han Jiaxin , Wang Yirong , Li Qingyang , Tan Zhenlin , Jiang Wenkang , Wang Yaru , Wang Jiaqi , Katsianis Antonios , Xu Xiaoju , Xu Haojie , Hong Wensheng , Mo Houjun , Wen Run , Zheng Xianzhong , Shi Feng , Zhang Pengjie , Zhai Zhongxu , Liu Chengze , Wang Wenting , Zu Ying , Guo Hong , Zhang Youcai , Lu Yi , Zheng Yi , Han Yunkun , Zou Hu , Wang Xin , Wei Chengliang , Li Ming , Luo Yu 
Published: March 2024

ABSTRACT
In this paper, we set out to construct a set of reference mock galaxy redshift surveys (MGRSs) for the future Chinese Space-station Survey Telescope (CSST) observation, where subsequent survey selection effects can be added and evaluated. This set of MGRSs is generated using the dark matter subhaloes extracted from a high-resolution Jiutian N-body simulation of the standard lambda-cold dark matter cosmogony with Ωm = 0.3111, ΩΛ = 0.6889, and σ8 = 0.8102. The simulation has a box size of 1 h−1Gpc, and consists of 61443 particles with mass resolution $3.723 \times 10^{8} \:h^{-1}\rm M_\odot$. In order to take into account the effect of redshift evolution, we first use all 128 snapshots in the Jiutian simulation to generate a light-cone halo/subhalo catalogue. Next, galaxy luminosities are assigned to the main and subhalo populations using the subhalo abundance matching (SHAM) method with the DESI (Dark Energy Spectroscopic Instrument) z-band luminosity functions at different redshifts. Multiband photometries, as well as images, are then assigned to each mock galaxy using a 3D parameter space nearest-neighbour sampling of the DESI LS (Legacy Imaging Survey) observational galaxies and groups. Finally, the CSST and DESI LS survey geometry and magnitude limit cuts are applied to generate the required MGRSs. As we have checked, this set of MGRSs can generally reproduce the observed galaxy luminosity/mass functions within 0.1 dex for galaxies with L &gt; 108  h-2 L⊙ (or M* &gt; 108.5 h-2M⊙) and within 1σ level for galaxies with L &lt; 108 h-2 L⊙ (or M* &lt; 108.5 h-2 M⊙). Together with the CSST slitless spectra and redshifts for our DESI LS seed galaxies that are under construction, we will set out to test various slitless observational selection effects in subsequent probes.
Searching for local features in primordial power spectrum using genetic algorithms
Authors: Lodha Kushal , Pinol Lucas , Nesseris Savvas , Shafieloo Arman , Sohn Wuhyun , Fasiello Matteo 
Published: March 2024

ABSTRACTWe present a novel methodology for exploring local features directly in the primordial power spectrum using a genetic algorithm pipeline coupled with a Boltzmann solver and Cosmic Microwave Background data (CMB). After testing the robustness of our pipeline using mock data, we apply it to the latest CMB data, including Planck 2018 and CamSpec PR4. Our model-independent approach provides an analytical reconstruction of the power spectra that best fits the data, with the unsupervised machine learning algorithm exploring a functional space built off simple ‘grammar’ functions. We find significant improvements upon the simple power-law behaviour, by Δχ2 ≲ −21, consistently with more traditional model-based approaches. These best-fits always address both the low-ℓ anomaly in the TT spectrum and the residual high-ℓ oscillations in the TT, TE, and EE spectra. The proposed pipeline provides an adaptable tool for exploring features in the primordial power spectrum in a model-independent way, providing valuable hints to theorists for constructing viable inflationary models that are consistent with the current and upcoming CMB surveys.
Characterization of starspots on a young M-dwarf K2-25: multiband observations of stellar photometric variability and planetary transits
Authors: Mori Mayuko , Ikuta Kai , Fukui Akihiko , Narita Norio , de Leon Jerome P , Livingston John H , Ikoma Masahiro , Kawai Yugo , Kawauchi Kiyoe , Murgas Felipe , Palle Enric , Parviainen Hannu , Rodríguez Gareb Fernández , Terada Yuka , Watanabe Noriharu , Tamura Motohide 
Published: March 2024

ABSTRACT
Detailed atmospheric characterization of exoplanets by transmission spectroscopy requires careful consideration of stellar surface inhomogeneities induced by star-spots. This effect is particularly problematic for planetary systems around M-dwarfs, and their spot properties are not fully understood. We investigated the stellar activity of the young M-dwarf K2-25 and its effect on transit observations of the sub-Neptune K2-25 b. From multiband monitoring observations of stellar brightness variability using ground-based telescopes and Transiting Exoplanets Survey Satellite, we found that the temperature difference between the spots and photosphere is &lt;190 K and the spot covering fraction is &lt;61 per cent (2σ). We also investigated the effect of starspot activity using multiepoch, multiband transit observations. We rule out cases with extremely low spot temperatures and large spot covering fractions. The results suggest that spots could distort the transmission spectrum of K2-25 b by as much as ∼100 ppm amplitude, corresponding to the precision of JWST/NIRSPEC of the target. Our study demonstrates that simultaneous multiband observations with current instruments can constrain the spot properties of M-dwarfs with good enough precision to support atmospheric studies of young M-dwarf planets via transmission spectroscopy.
S-phase checkpoint prevents leading strand degradation from strand-associated nicks at stalled replication forks
Authors: Bugallo Alberto , Sánchez Mar , Fernández-García María , Segurado Mónica 
Published: March 2024

Abstract
The S-phase checkpoint is involved in coupling DNA unwinding with nascent strand synthesis and is critical to maintain replication fork stability in conditions of replicative stress. However, its role in the specific regulation of leading and lagging strands at stalled forks is unclear. By conditionally depleting RNaseH2 and analyzing polymerase usage genome-wide, we examine the enzymology of DNA replication during a single S-phase in the presence of replicative stress and show that there is a differential regulation of lagging and leading strands. In checkpoint proficient cells, lagging strand replication is down-regulated through an Elg1-dependent mechanism. Nevertheless, when checkpoint function is impaired we observe a defect specifically at the leading strand, which was partially dependent on Exo1 activity. Further, our genome-wide mapping of DNA single-strand breaks reveals that strand discontinuities highly accumulate at the leading strand in HU-treated cells, whose dynamics are affected by checkpoint function and Exo1 activity. Our data reveal an unexpected role of Exo1 at the leading strand and support a model of fork stabilization through prevention of unrestrained Exo1-dependent resection of leading strand-associated nicks after fork stalling.
Sex-Dependent Occlusive Cardiovascular Disease Effects of Short-Term Thirdhand Smoke Exposure
Authors: Qadri Shahnaz , Maia Ana Carolina R G , Ali Hamdy E A , Alarabi Ahmed B , Alshbool Fatima Z , Khasawneh Fadi T 
Published: March 2024

Abstract

Introduction
Thirdhand smoke (THS) is associated with many public health and disease concerns, such as respiratory illness, cancer, lipidemia, and cardiovascular disease (CVD). We have previously shown that a moderate to long-term exposure to THS increases the risk of thrombosis. However, whether short-term exposure to THS would produce any effects remains to be discovered. Therefore, this study investigated the impact of 1-month THS exposure on platelet function, in vivo and in vitro, and on cytokine response, in a sex-dependent manner.

Aims and Methods
Secondhand smoke or clean air (CA) exposed upholstery materials for 1 week were kept in cages housed with 5–6 mice, and the procedure was repeated for 4 weeks. These THS-exposed mice were evaluated for thrombogenesis and platelet function assays. In addition, cytokines expression was evaluated from pooled serum.

Results
Compared to the CA group, THS exposure significantly shortened the tail bleeding time and carotid artery thrombus formation. Moreover, the female mice appeared more sensitive to THS exposure than males. Furthermore, platelet aggregation, dense granule secretion, and P-selectin activation markers were significantly elevated due to THS exposure. In addition, high-throughput screening showed at least 30 cytokines differentially modulated by THS in females relative to 26 in male mice.

Conclusions
Collectively, these results demonstrate that 1 month of THS exposure represents a high health risk, in part, by triggering a prothrombotic phenotype that appears to be more significant in females, who are at a much higher risk for occlusive CVD. Additionally, changes in cytokine levels mediate some of the THS-induced occlusive effects.

Implications
This study revealed that THS exposure for 1 month is detrimental to the cardiovascular health of both sexes; however, females could be more aggressively affected than males. In addition, interleukins and chemokines could be critical factors for initiating prothrombotic activity due to THS exposure.
Osimertinib in Patients With Treatment-Naive EGFR-Mutant Non-small Cell Lung Cancer: Overall Survival, Post-progression Management and Budget Impact Analysis in Real-World
Authors: Pasello Giulia , Lorenzi Martina , Scattolin Daniela , Del Conte Alessandro , Cecere Fabiana , Pavan Alberto , Macerelli Marianna , Polo Valentina , Pilotto Sara , Santarpia Mariacarmela , Cumerlato Enrico , Da Ros Valentina , Targato Giada , Bortolami Alberto , Bonanno Laura , Ferro Alessandra , Dal Maso Alessandro , Frega Stefano , Guarneri Valentina 
Published: March 2024

Abstract

Introduction
The observational multicenter prospective FLOWER study (NCT04965701) confirmed effectiveness and safety of osimertinib in the real-world (RW) management of untreated EGFR-mutant advanced non-small cell lung cancer (aNSCLC) patients.

Methods
Herein, we report updated survival data, post-progression management, cost/effectiveness and budget impact (BI) of osimertinib compared with a RW population receiving gefitinib or erlotinib.

Results
Overall, 189 Caucasian patients receiving first-line osimertinib were included. After a follow-up of 20.7 months, 74(39.2%) patients discontinued osimertinib, median time-to-treatment discontinuation (mTTD) was 27.9 months, overall survival 36.8 months. At progression, tissue biopsy was performed in 29 (56.9%), liquid biopsy in 15 (29.4%) and both in 7 (13.7%) cases. The most frequent resistant mechanism was MET amplification (N = 14, 29.8%). At data cutoff, 13 (6.9%) patients were continuing osimertinib beyond progression; 52 (67.5%) received second-line treatment; no further treatments were administered in 25 (32.5%) cases. Thirty-three (63.4%) patients received chemotherapy, 12(23.1%) TKIs combination. Cost–effectiveness analysis showed a total cost per patient based on RW mTTD of 98,957.34€, 21,726.28€ and 19,637.83€ for osimertinib, erlotinib and gefitinib, respectively. The incremental cost-effectiveness ratio (ICER)/month for osimertinib was 359,806.0€/life-year-gained (LYG) and 197,789.77€/LYG compared to erlotinib and gefitinib. For osimertinib, the BI-gap between RW-TTD and theoretical-TTD was 16,501.0€ per patient.

Conclusions
This updated analysis confirms the effectiveness of osimertinib in RW. Although the ICER of osimertinib seems not cost-effective, additional costs for the management of disease progression to old generation TKIs were not considered in this study. The BI-gap suggests RW mTTD as a more reliable measure for expense estimation.
Crisis, corruption and state-led development in the making of the Mexican drug trade
Authors: Morris Nathaniel 
Published: March 2024

Abstract
The state of Durango has long been a centre of Mexican heroin production and an important node in transnational drug trafficking networks. As early as 1944, it was the site of one of the biggest drug busts in Mexican history, when an opium poppy plantation the size of 325 football pitches, irrigated by a purpose-built aqueduct, was discovered in the state’s northern mountains. By the mid 1970s, a combination of kinship ties and concrete connected these poppy fields directly with the US drug market hub of Chicago, Illinois, along a route known as the ‘heroin highway’, which helped Mexico become the supplier of 90 per cent of US heroin. But how did a poor, underpopulated and overwhelmingly rural state become a major player in the billion-dollar US–Mexican drug trade? This article shows that in Durango, the rise of heroin production and trafficking were integral aspects of local processes of social, political and economic modernization. Stimulated by the Mexican and US governments’ promotion of infrastructural improvements and mass migration, and protected by representatives of Mexico’s post-revolutionary political system, the drug trade in turn fuelled further ‘licit’ economic development, making it part of the very foundation of Mexico as we know it today.
Panel Conditioning Biases in the Current Population Survey’s Food Security Supplement
Authors: Warren John Robert , Himmelstern Jessie , Halpern-Manners Andrew 
Published: March 2024

Abstract
We estimate the extent to which the methodological problem called panel conditioning biases the federal government’s estimates of the prevalence of food insecurity in the United States. To do so, we use 2002 through 2020 data from the Current Population Survey’s Food Security Supplement—the same data used to produce the federal government’s annual statistics about food insecurity. We take advantage of the CPS’s rotating panel design feature to estimate the effects of panel conditioning. By comparing CPS respondents who participated in the Food Security Supplement in each of two consecutive years but who—strictly by chance—were selected to begin the CPS one year apart, we both approximate an experimental design and derive estimates of panel conditioning that are purged of biases from panel attrition. For the 200,000+ unique households in our sample, the treatment is having previously participated in the Food Security Supplement; the outcome is participants’ subsequent responses to survey questions about food security. We find that in nearly every year people in the treatment group—that is, the group of people who have previously responded to the Food Security Supplement—are less likely to be food insecure than people responding for the first time. These differences are statistically significant and large in magnitude. We conclude that the federal government’s estimates of the prevalence of food insecurity in America are substantially biased; depending on the mechanism underlying panel conditioning, the true prevalence of food insecurity may be substantially higher or lower than officially reported.
Thermal Larmor Radiation
Authors: Ievlev Evgenii , Good Michael R R 
Published: March 2024

Abstract
Thermal radiation is found from a moving point charge along a special, globally defined, continuous accelerated trajectory. The calculation is entirely classical (despite the appearance of ℏ) but is shown to have an immediate connection to quantum field theory via the moving mirror model. A precise recipe is given for the functional mathematical identity of the electron–mirror duality that allows one to map between (1) the classical radiation of an ordinary accelerating point charge in 3+1 Minkowski spacetime and (2) the quantum radiation of a moving mirror in 1+1 flat spacetime, for a given rectilinear trajectory.
Toward a cultural sociology of taxation
Authors: Braunstein Ruth 
Published: March 2024

Abstract
This article advances calls for a cultural sociology of taxation by arguing that Zelizer’s theory of how monetary exchanges perform ‘relational work’ can be applied to taxpaying. Based on a review of research on taxpaying in the USA, I show this approach offers insight into a disparate set of puzzles about taxation including: why the USA continues to require income tax returns; why anti-tax sentiment persists even at low tax rates; why anti-government conservatives support some social spending; and whether linking taxpaying to citizenship promotes solidarity or racialized hierarchies. Recognizing that taxpaying involves relational work also reveals continuities with other forms of monetary exchange; and supplies evidence that relational work is performed at higher levels of relational abstraction than previously understood. While this article only gestures toward these possibilities, I hope it stimulates future research that fulfills the new fiscal sociology’s aspirations for a cultural sociology of taxation.
Electroencephalography connectome changes in chronic insomnia disorder are correlated with neurochemical signatures
Authors: Yu Liyong , Peng Wei , Lin Wenting , Luo Yucai , Hu Daijie , Zhao Guangli , Xu Hao , Dou Zeyang , Zhang Qi , Hong Xiaojuan , Yu Siyi 
Published: March 2024

Abstract

Study Objectives
This study aimed to investigate the alterations in resting-state electroencephalography (EEG) global brain connectivity (GBC) in patients with chronic insomnia disorder (CID) and to explore the correlation between macroscale connectomic variances and microscale neurotransmitter distributions.

Methods
We acquired 64-channel EEG from 35 female CID patients and 34 healthy females. EEG signals were source-localized using individual brain anatomy and orthogonalized to mitigate volume conduction. Correlation coefficients between band-limited source-space power envelopes of the DK 68 atlas were computed and averaged across regions to determine specific GBC values. A support vector machine (SVM) classifier utilizing GBC features was employed to differentiate CID patients from controls. We further used Neurosynth and a 3D atlas of neurotransmitter receptors/transporters to assess the cognitive functions and neurotransmitter landscape associated with CID cortical abnormality maps, respectively.

Results
CID patients exhibited elevated GBC within the medial prefrontal cortex and limbic cortex, particularly at the gamma carrier frequency, compared to controls (pFDR &lt; .05). GBC patterns were found to effectively distinguish CID patients from controls with a precision of 90.8% in the SVM model. The cortical abnormality maps were significantly correlated with meta-analytic terms like “cognitive control” and “emotion regulation.” Notably, GBC patterns were associated with neurotransmitter profiles (pspin &lt; .05), with neurotransmitter systems such as norepinephrine, dopamine, and serotonin making significant contributions.

Conclusions
This work characterizes the EEG connectomic profile of CID, facilitating the cost-effective clinical translation of EEG-derived markers. Additionally, the linkage between GBC patterns and neurotransmitter distribution offers promising avenues for developing targeted treatment strategies for CID.
Italian resident individuals with interests in Liechtenstein entities: notes on Italian income taxes—Part 2
Authors: Quartana Claudio , Bolis Lodovico 
Published: March 2024

Abstract
It is not uncommon for Italian resident taxpayers to resort to Liechtenstein entities for taking advantage of the benefits that they can offer, like asset protection, confidentiality and favorable taxation. After having dealt, inter alia, with Liechtenstein foundations and establishments in Part 1, Part 2 focuses on the holding of participations in Liechtenstein limited companies by Italian resident individuals. In this regard, the tax treatment of dividends, capital gains and “the Italian Controlled Foreign Companies regime” are addressed. Finally, a few remarks are made on some income tax planning opportunities and criticalities in light of the Italian tax legislative framework described in Part 1 and Part 2.
Loudness Balancing Optimization for Better Speech Intelligibility, Music Perception, and Spectral Temporal Resolution in Cochlear Implant Users
Authors: Deniz Burcu , Deniz Rişvan , Ataş Ahmet 
Published: March 2024

Hypothesis
The behaviorally based programming with loudness balancing (LB) would result in better speech understanding, spectral–temporal resolution, and music perception scores, and there would be a relationship between these scores.

Background
Loudness imbalances at upper stimulation levels may cause sounds to be perceived as irregular, gravelly, or overly echoed and may negatively affect the listening performance of the cochlear implant (CI) user. LB should be performed after fitting to overcome these problems.

Methods
The study included 26 unilateral Med-EL CI users. Two different CI programs based on the objective electrically evoked stapedial reflex threshold (P1) and the behaviorally program with LB (P2) were recorded for each participant. The Turkish Matrix Sentence Test (TMS) was applied to evaluate speech perception; the Random Gap Detection Test (RGDT) and Spectral-Temporally Modulated Ripple Test (SMRT) were applied to evaluate spectral temporal resolution skills; the Mini Profile of Music Perception Skills (mini-PROMS) and Melodic Contour Identification (MCI) tests were applied to evaluate music perception, and the results were compared.

Results
Significantly better scores were obtained with P2 in TMS tests performed in noise and quiet. SMRT scores were significantly correlated with TMS in quiet and noise, and mini-PROMS sound perception results. Although better scores were obtained with P2 in the mini-PROMS total score and MCI, a significant difference was found only for MCI.

Conclusion
The data from the current study showed that equalization of loudness across CI electrodes leads to better perceptual acuity. It also revealed the relationship between speech perception, spectral–temporal resolution, and music perception.
Both major xanthophyll cycles present in nature can provide Non-Photochemical Quenching in the model diatomPhaeodactylum tricornutum
Authors: Giossi Chiara E. , Wünsch Marie A. , Dautermann Oliver , Schober Alexander F. , Buck Jochen M. , Kroth Peter G. , Lohr Martin , Lepetit Bernard 
Published: March 2024

AbstractXanthophyll cycling contributes to photoprotection by regulating Non-Photochemical Quenching (NPQ). While most photosynthetic eukaryotes including land plants use the violaxanthin cycle, some algae like diatoms and haptophytes rely on the diadinoxanthin cycle for photoprotection. These algae also contain minor amounts of violaxanthin cycle pigments, serving as precursors in xanthophylls biosynthesis. Both cycles are catalyzed by the enzymes violaxanthin de-epoxidase (VDE) and zeaxanthin epoxidase (ZEP). Here, we characterized the role ofVDEand different ZEP-encoding paralogs (ZEP2andZEP3) in the model diatomPhaeodactylum tricornutum. While knockout ofVDEandZEP3significantly impaired the diadinoxanthin cycle, lack ofZEP2led to sustained accumulation of the violaxanthin cycle instead of diadinoxanthin cycle pigments under high irradiance, with no negative effect on NPQ capacity. We demonstrate that both major xanthophyll cycles present in nature can function with comparable efficiency within the same species, offering a new perspective on the evolution of xanthophyll-mediated photoprotection.