bluuebunny/crossref_metadata_2025_split huggingface dataset:
Syllable contact effects as a diachronic precursor to mora licensing in early French /sC/ clusters
Authors: Montaño Francisco Antonio 
Published: April 2024

This paper proposes that Old French coda /s/ deletion (11th-13th centuries) forms part of a broader diachronic progression of ever-stricter requirements on the sonority contour of /sC/ clusters in syllable contact, reframing part of a well-known moraic analysis (Gess 1998a, 1999, and later work) of Old French coda loss phenomena. Given the multistage rollout of coda /s/ deletion as a function of the sonority of the following onset, an approach hinging on syllable contact constraints not only offers a more detailed and precise formalization of the diachrony of word-medial /sC/ in Old French, but also draws systemic connections with cognate processes affecting /sC/ clusters in early French such as prothesis and earlier Proto-French stop epenthesis. The Optimality-Theoretic analysis presented here formalizes these phenomenological links and the constraints on syllable-contact sonority using the Split Margin Approach to the Syllable (Baertsch 2002, Baertsch & Davis 2003). Rather than sonority-graded mora-licensing constraints causing Old French coda /s/ deletion, the present account argues that their ranking above Faith is instead the acquisitional outcome of the near-total absence of coda /s/ across the lexicon, as a culminative result of the progressive tightening of syllable contact requirements.
INFLUENCE OF WORKING CONDITIONS ON THE STATE OF HEALTH AND LABORATORY INDICATORS OF EMPLOYEES WHEN PERFORMING WELDING WORKS
Authors: Власова Наталья Викторовна , Абдрахманова Елена Рафиловна , Масягутова Ляйля Марселевна , Карамова Лена Мирзаевна , Рафикова Линара Альфировна , Музафарова Алина Риннатовна , Бояринова Наталья Владимировна 
Published: April 2024

В настоящее время профессия сварщика является одной из самых востребованных в различных отраслях промышленности. Цель работы — проанализировать условия труда, показатели здоровья и определить значимость лабораторных исследований, регламентированных в рамках периодических медицинских осмотров для своевременной диагностики изменений в состоянии здоровья электрогазосварщиков, работающих и проживающих на территории Республики Башкортостан. Проведено клинико- диагностическое обследованиеработников-электрогазосварщиков, работающих на предприятиях республики. Рассмотрено влияние вредных производственных факторов: химического, физического и тяжести трудового процесса. Выявлены заболевания костно- мышечной и нервной систем, болезни системы кровообращения, органов дыхания и нейросенсорная тугоухость с признаками воздействия шума. Диагностированы достоверные изменения лабораторных показателей в зависимости от стажа работы и длительности контакта с производственными факторами. Необходимо проведение диспансерного наблюдения данной категории рабочих с разработкой и обоснованием индивидуальных медико- профилактических мероприятий.
Currently, the profession of a welder is one of the most sought after in various industries. The purpose of the work is to analyze working conditions, health indicators anddetermine the significance of laboratory tests regulated as part of periodic medical examinations for the timely diagnosis of changes in the health status of electric and gas welders working andliving on the territory of the Republic of Bashkortostan. A clinical and diagnostic examination of workers — electric and gas welders working at the enterprises of the republic was carried out. Theinfluence of harmful production factors is considered: chemical, physical and the severity of the labor process. Diseases of the musculoskeletal and nervous systems, diseases of the circulatorysystem, respiratory organs, and sensorineural hearing loss with signs of noise exposure were identified. Reliable changes in laboratory parameters were diagnosed depending on the length ofservice and the duration of contact with production factors. It is necessary to carry out dispensary observation of this category of workers with the development and justification of individual medical and preventive measures.
Comparing the outcomes and costs of cardiac monitoring with implantable loop recorders and mobile cardiac outpatient telemetry following stroke using real-world evidence
Authors: Norlock Vincent , Vazquez Reynaldo , Dunn Alexandria , Siegfried Christian , Wadhwa Manish , Medic Goran 
Published: April 2024

Aim:
Patients with ischemic stroke (IS) commonly undergo monitoring to identify atrial fibrillation with mobile cardiac outpatient telemetry (MCOT) or implantable loop recorders (ILRs). The authors compared readmission, healthcare cost and survival in patients monitored post-stroke with either MCOT or ILR.
Materials & methods:
The authors used claims data from Optum's de-identified Clinformatics
®
Data Mart Database to identify patients with IS hospitalized from January 2017 to December 2020 who were prescribed ambulatory cardiac monitoring via MCOT or ILR. They compared the costs associated with the initial inpatient visit as well as the rate and causes of readmission, survival and healthcare costs over the following 18 months. Datasets were balanced using patient baseline and hospitalization characteristics. Multivariable generalized linear gamma regression was used for cost comparisons. Cox proportional hazard regression was used for survival and readmission analysis. Sub-cohorts were analyzed based on the severity of the index IS.
Results:
In 2244 patients, readmissions were significantly lower in the MCOT monitored group (30.2%) compared with the ILR group (35.4%) (hazard ratio [HR] 1.23; 95% CI: 1.04–1.46). Average cost over 18 months starting with the index IS was $27,429 (USD) lower in the MCOT group (95% CI: $22,353–$32,633). Survival difference bordered on statistical significance and trended to lower mortality in MCOT (8.9%) versus ILR (11.3%) (HR 1.30; 95% CI: 1:00–1.69), led by significance in patients with complications or comorbidities with the index event (MCOT 7.5%, ILR 11.5%; HR 1.62; 95% CI: 1.11–2.36).
Conclusion:
The use of MCOT versus ILR as the primary monitor following IS was associated with significant decreases in readmission, lower costs for the initial IS and total care over the next 18 months, significantly lower mortality for patients with complications and comorbidities at the index stroke, and a trend toward improved survival across all patients.
Removal Efficiency of Phenolic Compounds (Bisphenol A and Pentachlorophenol) by Adsorption Using a Bentonite-CTAB
Authors: Hadoudi Nouhaila , Ahari M’hamed , Zaki Najlae , Charki Asmae , El Ouarghi Hossain , Bayoussef Ayoub , Mansori Mohammed , Fouad Mourabit , Salhi Amin , Amhamdi Hassan 
Published: April 2024

Bentonite clay modified with cetyltrimethylammonium bromide (CTAB) has been investigated as an effective adsorbent for the removal of bisphenol A (BPA) and pentachlorophenol (PCP) from aqueous solutions. The adsorption performance of Bentonite-CTAB was evaluated by conducting batch adsorption experiments under different conditions. The adsorption isotherms of BPA and PCP on Bentonite-CTAB (BT-CTAB) were analyzed using the Langmuir and Freundlich models. The Langmuir model provided a better fit to the experimental data, suggesting the presence of monolayer adsorption. The adsorption kinetics of BPA and PCP on Bentonite-CTAB were studied using pseudo-first-order and pseudo-second-order models. The results indicate that the adsorption process follows pseudo-second-order kinetics, suggesting that the adsorption is controlled principally by chemisorption. Equilibrium time for both pollutants was achieved within 30–40 min. The results of adsorption studies indicated that Bentonite-CTAB exhibited excellent adsorption capacity for bisphenol A and pentachlorophenol. The high surface area and presence of active sites on Bentonite-CTAB favored adsorption of pollutants from aqueous solution. The adsorption process adopted pseudo-second-order kinetics, indicating the involvement of chemisorption. the adsorption isotherms of BPA and PCP on Bentonite-CTAB were analyzed using the Langmuir and Freundlich models. The Langmuir model provided a better fit to the data, suggesting monolayer adsorption.
Leveraging On Corporate Governance For Supply Chain Resilience Of Sugar Manufacturing Firms In Kenya
Authors: Oloo Antony Okoth , Ochieng’ Evans Bob 
Published: April 2024

Sugar manufacturing firms in Kenya have faced a myriad of challenges with regard to cost control, production inefficiencies, incompetent management and lack of information technology integration in production issues which are directly controlled by management. The influence of corporate governance on supply chain resilience of sugar manufacturing firms in Kenya thus cannot be underrated. The specific objective of the study was; to assess the effect of Corporate Governance on Supply chain Resilience of Sugar Manufacturing firms in Kenya. The research study methodology followed a descriptive approach with a target population of the study of 240 respondents, covering various departments within the Sugar firms. A census survey was conducted on all the 15 registered sugar manufacturing firms in Kenya. Data collected was analyzed by both descriptive and inferential statistics using statistical package for social sciences (SPSS Version 28). Descriptive statistics involved calculation of means, frequencies, percentages and standard deviation. Inferential statistics on the other hand included the use of Pearson correlation coefficient to determine the extent of relationship among the independent study variables, while multiple regression analysis was used to establish the relationship between corporate governance and supply chain resilience. Findings from data analysis in the study indicated that corporate governance was significantly responsible for the supply chain resilience of sugar manufacturing firms in Kenya. Consequently, yielding a positive relationship in the regression model. The findings from the regression model indicated that corporate governance, significantly and positively affected supply chain resilience of sugar manufacturing firms in Kenya. The study therefore recommended that the management of sugar manufacturing firms in Kenya in collaboration with the appointing authorities should embrace good practices when appointing managing directors in-charge of the sugar firms to achieve supply chain resilience through, continuous production, resource optimization, quality output and general bottom line improvement.
Clinico-morphological characteristics of SMARCA4-deficient lung cancer
Authors: Orlova R.  V. , Raskin G. A. , Morozova A. S. , Fedorova A. V. 
Published: April 2024

Background. Mutations in the SMARCA4 gene of the SWI/SNF chromatin remodeling complex occur in 10% of nonsmall cell lung cancer (NMRL). SMARCA4-deficient lung tumors are aggressive neoplasm with poor outcome. Morphological, immunohistochemical and clinical description of this tumor type is lacking.The aim of the study was to investigate clinical and morphological characteristics and frequency of SMARCA4 expression loss in patients with lung tumors.Material and methods. Specimens from a total 100 non-small cell lung cancer cases were immunohistochemically examined for expression of SMARCA4 and SMARCA2. EGFR, BRAF mutations and gene rearrangement of ALK or ROS1 were tested by immunohistochemical, PCR-based or FISH techniques among cases with loss of SMARCA4 expression.Results. Loss of SMARCA4 expression was detected in 14 (14%) cases. Most of them are men — 93%. The average age was 63 years. In most cases (64%) SMARCA4-deficient tumors have been diagnosed as adenocarcinoma. The mutation was significantly associated with smoking history (p-value 0.009). Mutations in EGFR, BRAF genes and rearrangement of ALK or ROS1 in the SMARCA4-deficient tumor group have not been detected.Conclusion. SMARCA4-deficient tumors are subgroup of NMRL, prevalent in smoking men and diagnosed as lung adenocarcinoma without activating mutations.
Efficacy of propolis extract and eye drop solutions to suppress encystation and excystation of Acanthamoeba triangularis WU19001-T4 genotype
Authors: Sangkanu Suthinee , Siyadatpanah Abolghasem , Norouzi Roghayeh , Chuprom Julalak , Mitsuwan Watcharapong , Surinkaew Sirirat , Boonhok Rachasak , Paul Alok K. , Mahboob Tooba , Sama-ae Imran , Oliveira Sonia M. R. , Jimoh Tajudeen O. , Pereira Maria de Lourdes , Wilairatana Polrat , Wiart Christophe , Rahmatullah Mohammed , Sakolnapa Monvaris , Nissapatorn Veeranoot 
Published: April 2024

Background
Propolis is a natural resinous product from a variety of plants and combines it with beeswax and salivary enzymes to create bee glue. Its potentials have been employed in the treatment of many diseases and conditions for centuries. This study, therefore, aims to determine the anti-Acanthamoeba properties of the propolis extract, eye drops coupled to some mechanisms such as inhibition of encystation and excystation.

Methods
The minimum inhibitory concentrations (MICs) of the most active propolis extract were assessed in trophozoites and cysts of Acanthamoeba triangularis (A. triangularis) at 0.256 and 1 mg/mL, respectively.

Results
Active eye drops inhibited trophozoites and cysts with a MIC value of 100%. At concentrations lower than their MICs values (1/2–1/16 MIC), propolis and eye drops revealed inhibition of encystation. In addition, at 1/2 MIC, both the propolis extract and eye drops showed potential inhibition of excystation. In combined sets of propolis extract and eye drops, they showed slightly increasing inhibition of encystation and excystation. Surprisingly, the MIC of chlorhexidine decreased when combined with the propolis and eye drops. SEM and TEM images displayed morphological changes in A. triangularis treated with combined sets of propolis extract and eye drops.

Conclusion
From this study, a new combined eye drop solution with propolis extract was found to be helpful in reducing encystation and excystation in A. triangularis. Therefore, this combination is an alternative for the treatment of eye diseases in early stages along with reducing the entry into the cyst stage of Acanthamoeba. The results of this study revealed new anti-Acanthamoeba inhibitors with promising combined alternative therapeutic potential for the treatment of Acanthamoeba keratitis.
Riverbank Filtration for Drinking Water Supply
Authors: Ray Chittaranjan , Grischek Thomas , Hubbs Stephen , Drewes Jorg , Haas David , Darnault Christophe 
Published: October 2008

AbstractRiverbank filtration (RBF) is a low‐cost water treatment/pretreatment technology that is used in many countries around the world for water supply. When wells are situated close to rivers or lakes and pumped, the surface water is induced to flow to these wells. During soil and aquifer passage, chemical, biological, and particulate contaminants are removed. Many European cities have been using RBF as the primary source of drinking water production for over a century. In the United States, RBF is gaining popularity owing to favorable regulatory provisions. In siting and designing RBF systems, the river hydrology and site hydrogeology must be carefully considered so that scouring and clogging are avoided and the aquifer is conductive to produce the desired amount of water. The source water should be of reasonably high quality to avoid the development of anoxic conditions, which ultimately may lead to the reduction of iron, manganese, and other redox‐sensitive species. Three‐dimensional computer models are increasingly being used for the placement and operation of RBF systems. The collection system can be vertical wells, horizontal collector wells, infiltration galleries, or combinations of any two or all three. Site‐specific conditions, pumping needs, and the availability of treatment plants for further treatment of the filtrate dictate the type of collection system. The capital cost is tied to the type of collection system, conveyance system, and land acquisition. Numerous studies have pointed out the benefits of RBF in removing turbidity, pathogens, dissolved chemicals, natural organics (which are regarded as precursors for disinfection by‐products for systems using chlorine as the disinfectant), and a whole host of micropollutants.
Contaminated Sediments: Inorganic Constituents
Authors: Horowitz Arthur J 
Published: October 2008

AbstractOwing to a variety of physical and chemical factors, in conjunction with aquatic physicochemical conditions, fluvial/lacustrine suspended and bed sediments can act as both sources and carriers of a wide variety of inorganic constituents and nutrients. Many of these constituents reflect local environmental conditions and are derived from both point and nonpoint sources. When sources have an anthropogenic origin, and chemical levels exceed the typical range of local baseline concentrations, sediments can be described as contaminated. Most land‐use categories (e.g. agriculture, forested, and rangeland) do not appear to exert a substantial effect on sediment‐associated inorganic chemical levels. On the other hand, mining and/or mining‐related activities are a major exception, and although this land use can be geographically limited, it can cause extensive local and downstream sediment contamination. Urban centers and urbanization (increasing amounts of impervious surfaces), as a result of industrial and wastewater discharges, power generation, and transportation‐related activities, also can cause extensive sediment contamination. Population density can be related to urbanization and, at levels ≥27 people (p) km−2, also appears to exercise a substantive effect on sediment chemistry. In fact, population density appears to be a more consistent influence than urban percentage, and displays stronger positive correlations with sediment contamination. The most common sediment‐associated inorganic/nutrient contaminants appear to be Pb, Hg, Ag, Zn, Cd, Cu, Sb, S, Ni, Sn, Cr, As, TC (total carbon), Co, Fe, P, and TOC (total organic carbon).
Cardiomyopathic Syrian Hamster as a Model of Congestive Heart Failure
Authors: Goineau Sonia , Picard Sandra , Hervé Stéphane , Lacroix Pierre 
Published: October 2008

AbstractCardiomyopathic Syrian hamsters (Bio TO‐2 dilated strain) constitute an animal model of congestive heart failure, which progressively develops an alteration of cardiac function leading to decreased arterial blood pressure and musculo‐cutaneous blood flow associated with a complex process of cardiac remodeling including left ventricle dilation, wall thinning, and greater collagen density. The protocols described in this unit are designed to assess the pharmacological effects of new therapeutic strategies on cardiac and systemic hemodynamics, morphometry (body and target organs weight), cardiac remodeling (left ventricle dilation and collagen density), and survival in this model of dilated cardiomyopathy. Examples of results obtained with enalapril, an angiotensin I converting enzyme inhibitor, are provided for illustrative purposes.Curr. Protoc. Pharmacol. 42:5.50.1‐5.50.12. © 2008 by John Wiley & Sons, Inc.
The IND Application
Authors: Ferkany John W. , Williams Michael 
Published: October 2008

AbstractTranslational biomedical research is often directed to the introduction of a new drug or biologic intended to treat unmet medical need in humans. This unit describes the timing and content of the investigational new drug (IND) application, the primary document required by the U.S. FDA for the initiation of clinical trials in humans with any new chemical entity (NCE) or biologic. The IND application contains all the information necessary for the FDA to make an assessment of the risks and benefits of the proposed clinical trials for the NCE/biologic, containing a detailed but succinct description of the biology, safety, toxicology, chemistry and manufacturing process, and the proposed clinical plan. This unit is geared for those with little or no experience with the IND process and is intended as a global introduction to this, the initial stage of the drug development process for drugs used in humans. Curr. Protoc. Pharmacol. 42:9.10.1‐9.10.23. © 2008 by John Wiley & Sons, Inc.
Thin‐Layer Chromatography
Authors: Meyers C.L.F. , Meyers D.J. 
Published: October 2008

AbstractTLC is used extensively in nucleic acid chemistry to monitor the progress of chemical reactions, to assay fractions collected from a larger chromatographic separation (e.g., column chromatography), and to determine optimal conditions prior to column chromatography. This unit describes methods for spotting test compounds onto a TLC plate, developing the plate in a suitable solvent system, visualizing the results, and calculating the retention factor (Rf). Candidate compounds can be co‐spotted for identification without relying on Rf values. Curr. Protoc. Nucleic Acid Chem. 34:A.3D.1‐A.3D.13. © 2008 by John Wiley & Sons, Inc.
Identifying Protein Domains with the Pfam Database
Authors: Coggill Penny , Finn Robert D. , Bateman Alex 
Published: October 2008

AbstractPfam is a database of protein domain families, with each family represented by multiple sequence alignments and profile hidden Markov models (HMMs). In addition, each family has associated annotation, literature references, and links to other databases. The entries in Pfam are available via the World Wide Web and in flatfile format. This unit contains detailed information on how to access and utilize the information present in the Pfam database, namely the families, multiple alignments, and annotation. Details on running Pfam, both remotely and locally are presented. Curr. Protoc. Bioinform. 23:2.5.1‐2.5.17. © 2008 by John Wiley & Sons, Inc.
Data Storage and Analysis in ArrayExpress and Expression Profiler
Authors: Rustici Gabriella , Kapushesky Misha , Kolesnikov Nikolay , Parkinson Helen , Sarkans Ugis , Brazma Alvis 
Published: October 2008

AbstractArrayExpress at the European Bioinformatics Institute is a public database for MIAME‐compliant microarray and transcriptomics data. It consists of two parts: the ArrayExpress Repository, which is a public archive of microarray data, and the ArrayExpress Warehouse of Gene Expression Profiles, which contains additionally curated subsets of data from the Repository. Archived experiments can be queried by experimental attributes, such as keywords, species, array platform, publication details, or accession numbers. Gene expression profiles can be queried by gene names and properties, such as Gene Ontology terms, allowing expression profiles visualization. The data can be exported and analyzed using the online data analysis tool named Expression Profiler. Data analysis components, such as data preprocessing, filtering, differentially expressed gene finding, clustering methods, and ordination‐based techniques, as well as other statistical tools are all available in Expression Profiler, via integration with the statistical package R. Curr. Protoc. Bioinform. 23:7.13.1‐7.13.27. © 2008 by John Wiley & Sons, Inc.