bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of edible coating containing Aloe vera extracts on the oxidative stability and quality parameters of cooked ground chicken meat
Authors: Yılmaz G. , Küçük A.İ. , Bilecen Şen D. , Kılıç B. 
Published: March 2024

This study investigated the impact of incorporating Aloe vera gel (AVG) and Aloe vera leaf skin (AVLS) extracts into edible coating (EC) on retarding lipid oxidation and enhancing the quality characteristics of cooked ground chicken meat during 14 days of storage at 4 °C. The results indicated that both AVG and AVLS extracts had a similar amount of total phenolic contents. EC application resulted in a decrease in pH values, and an increase in aw values. The addition of 2% AVG or AVLS extracts into EC formulation also decreased TBARS and ORP values. Although textural properties were not affected by EC application containing AVG or AVLS extracts, this application retarded L*, a*, and b* color values. The results indicated that Aloe vera extracts may be incorporated into EC by processors to improve lipid oxidation inhibition and maintain the quality characteristics of poultry meat products during refrigerated storage.
Potent HPIV3-neutralizing IGHV5-51 Antibodies Identified from Multiple Individuals Show L Chain and CDRH3 Promiscuity
Authors: Abu-Shmais Alexandra A , Miller Rose J , Janke Alexis K , Wolters Rachael M , Holt Clinton M , Raju Nagarajan , Carnahan Robert H , Crowe James E , Mousa Jarrod J , Georgiev Ivelin S 
Published: March 2024

Abstract
Human parainfluenza virus 3 (HPIV3) is a widespread pathogen causing severe and lethal respiratory illness in at-risk populations. Effective countermeasures are in various stages of development; however, licensed therapeutic and prophylactic options are not available. The fusion glycoprotein (HPIV3 F), responsible for facilitating viral entry into host cells, is a major target of neutralizing Abs that inhibit infection. Although several neutralizing Abs against a small number of HPIV3 F epitopes have been identified to date, relatively little is known about the Ab response to HPIV3 compared with other pathogens, such as influenza virus and SARS-CoV-2. In this study, we aimed to characterize a set of HPIV3-specific Abs identified in multiple individuals for genetic signatures, epitope specificity, neutralization potential, and publicness. We identified 12 potently neutralizing Abs targeting three nonoverlapping epitopes on HPIV3 F. Among these, six Abs identified from two different individuals used Ig heavy variable gene IGHV 5-51, with five of the six Abs targeting the same epitope. However, despite the use of the same H chain variable (VH) gene, these Abs used multiple different L chain variable genes (VL) and diverse H chain CDR 3 (CDRH3) sequences. Together, these results provide further information about the genetic and functional characteristics of HPIV3-neutralizing Abs and suggest the existence of a reproducible VH-dependent Ab response associated with VL and CDRH3 promiscuity. Understanding sites of HPIV3 F vulnerability and the genetic and molecular characteristics of Abs targeting these sites will help guide efforts for effective vaccine and therapeutic development.
Almost sure convergence of the
$L^4$
norm of Littlewood polynomials
Authors: Duan Yongjiang , Fang Xiang , Zhan Na 
Published: March 2024

AbstractThis paper concerns the
$L^4$
norm of Littlewood polynomials on the unit circle which are given by
$$ \begin{align*}q_n(z)=\sum_{k=0}^{n-1}\pm z^k;\end{align*} $$
i.e., they have random coefficients in
$\{-1,1\}$
. Let
$$ \begin{align*}||q_n||_4^4=\frac{1}{2\pi}\int_0^{2\pi}|q_n(e^{i\theta})|^4 d\theta.\end{align*} $$
We show that
$||q_n||_4/\sqrt {n}\rightarrow \sqrt [4]{2}$
almost surely as
$n\to \infty $
. This improves a result of Borwein and Lockhart (2001, Proceedings of the American Mathematical Society 129, 1463–1472), who proved the corresponding convergence in probability. Computer-generated numerical evidence for the a.s. convergence has been provided by Robinson (1997, Polynomials with plus or minus one coefficients: growth properties on the unit circle, M.Sc. thesis, Simon Fraser University). We indeed present two proofs of the main result. The second proof extends to cases where we only need to assume a fourth moment condition.
Evaluation of hybrid closed-loop insulin delivery system in type 1 diabetes in real-world clinical practice: One-year observational study
Authors: Eldib Ahmed , Dhaver Shilton , Kibaa Karim , Atakov-Castillo Astrid , Salah Tareq , Al-Badri Marwa , Khater Abdelrahman , McCarragher Ryan , Elenani Omnia , Toschi Elena , Hamdy Osama 
Published: March 2024

BACKGROUND
In 2016, the Food and Drug Administration approved the first hybrid closed-loop (HCL) insulin delivery system for adults with type 1 diabetes (T1D). There is limited information on the impact of using HCL systems on patient-reported outcomes (PROs) in patients with T1D in real-world clinical practice. In this independent study, we evaluated glycemic parameters and PROs over one year of continuous use of Medtronic’s 670G HCL in real-world clinical practice.
AIM
To assess the effects of hybrid closed loop system on glycemic control and quality of life in adults with T1D.
METHODS
We evaluated 71 patients with T1D (mean age: 45.5 ± 12.1 years; 59% females; body weight: 83.8 ± 18.7 kg, body mass index: 28.7 ± 5.6 kg/m2, A1C: 7.6% ± 0.8%) who were treated with HCL at Joslin Clinic from 2017 to 2019. We measured A1C and percent of glucose time-in-range (%TIR) at baseline and 12 months. We measured percent time in auto mode (%TiAM) for the last two weeks preceding the final visit and assessed PROs through several validated quality-of-life surveys related to general health and diabetes management.
RESULTS
At 12 mo, A1C decreased by 0.3% ± 0.1% (P = 0.001) and %TIR increased by 8.1% ± 2.5% (P = 0.002). The average %TiAM was only 64.3% ± 32.8% and was not associated with A1C, %TIR or PROs. PROs, provided at baseline and at the end of the study, showed that the physical functioning submodule of 36Item Short-Form Health Survey increased significantly by 22.9% (P < 0.001). Hypoglycemia fear survey/worry scale decreased significantly by 24.9% (P < 0.000); Problem Areas In Diabetes reduced significantly by -17.2% (P = 0.002). The emotional burden submodules of dietary diversity score reduced significantly by -44.7% (P = 0.001). Furthermore, analysis of Clarke questionnaire showed no increase in awareness of hypoglycemic episodes. WHO-5 showed no improvements in subject’s wellbeing among participants after starting the 670G HCL system. Finally, analysis of Pittsburgh Sleep Quality Index showed no difference in sleep quality, sleep latency, or duration of sleep from baseline to 12 mo.
CONCLUSION
The use of HCL in real-world clinical practice for one year was associated with significant improvements in A1C, %TIR, physical functioning, hypoglycemia fear, emotional distress, and emotional burden related to diabetes management. However, these changes were not associated with time in auto mode.
Diabetes and high-glucose could upregulate the expression of receptor for activated C kinase 1 in retina
Authors: Tan Jian , Xiao Ang , Yang Lin , Tao Yu-Lin , Shao Yi , Zhou Qiong 
Published: March 2024

BACKGROUND
Diabetic retinopathy (DR) is a major ocular complication of diabetes mellitus, leading to visual impairment. Retinal pigment epithelium (RPE) injury is a key component of the outer blood retinal barrier, and its damage is an important indicator of DR. Receptor for activated C kinase 1 (RACK1) activates protein kinase C-ε (PKC-ε) to promote the generation of reactive oxygen species (ROS) in RPE cells, leading to apoptosis. Therefore, we hypothesize that the activation of RACK1 under hypoxic/high-glucose conditions may promote RPE cell apoptosis by modulating PKC-ε/ROS, thereby disrupting the barrier effect of the outer blood retinal barrier and contributing to the progression of DR.
AIM
To investigate the role and associated underlying mechanisms of RACK1 in the development of early DR.
METHODS
In this study, Sprague-Dawley rats and adult RPE cell line-19 (ARPE-19) cells were used as in vivo and in vitro models, respectively, to explore the role of RACK1 in mediating PKC-ε in early DR. Furthermore, the impact of RACK1 on apoptosis and barrier function of RPE cells was also investigated in the former model.
RESULTS
Streptozotocin-induced diabetic rats showed increased apoptosis and up-regulated expression of RACK1 and PKC-ε proteins in RPE cells following a prolonged modeling. Similarly, ARPE-19 cells exposed to high glucose and hypoxia displayed elevated mRNA and protein levels of RACK1 and PKC-ε, accompanied by an increases in ROS production, apoptosis rate, and monolayer permeability. However, silencing RACK1 significantly downregulated the expression of PKC-ε and ROS, reduced cell apoptosis and permeability, and protected barrier function.
CONCLUSION
RACK1 plays a significant role in the development of early DR and might serve as a potential therapeutic target for DR by regulating RPE apoptosis and barrier function.
Preparation, spectroscopic and anticancer investigations of metal-drug complexes associated between flumequine antibiotic drug with lanthanum(III), samarium(III) and terbium(III) chloride
Authors: A. El-Habeeb Abeer , Y. El-Sayed Mohamed , M.A. Alatawy Ibrahim , S.  Refat Moamen 
Published: March 2024

Flumequine ligand (FLQ) metal complexes of the [M(FLQ)2(Cl)(H2O)].nH2O type, where M are (La(III), Sm(III), and Tb(III)) and FLQ is flumequine have been synthesized. The FLQ metal complexes could be prepared using MCl3 : flumequine in stoichiometry of 1:2 in situ bidentate chelation. The characterization of FLQ complexes obtained have been done using elemental analyses (%C, %H and %N), molar conductivity (Ʌm), infrared spectroscopy (FTIR), electronic spectra (UV-Vis), thermal analysis (TGA), and physicochemical techniques such as X-ray powder diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive X-ray (EDX) measurements at room temperature. Accordingly, these complexes are indicative of an octahedral coordination structure. Flumequine ligand has a bidentate fashion through the oxygen atoms of carbonyl (quinolone) and carboxylic groups. The findings demonstrated the anti-cancer efficacy of these compounds against HepG-2 and MCF-7 cancer cell lines at extremely low doses of up to 58.2 mg/mL. The La(III) complex was shown to have the highest selectivity against cancer cells in comparable with both samarium and terbium(III) complexes.
KEY WORDS: Flumequine, Lanthanide metal ions, FTIR, EDX, Complexation, Anticancer activity
Bull. Chem. Soc. Ethiop. 2024, 38(3), 671-684.
DOI: https://dx.doi.org/10.4314/bcse.v38i3.10
Thermodynamic modeling of the solid-liquid equilibrium of two phenolic compounds in several solvents at temperatures ranging from 283.15 K to 323.15 K
Authors: Noubigh Adel 
Published: March 2024

The solubility of two natural phenolic compounds (vanillic acid (VA) and vanillin (V)) in four individual solvents (ethanol, butan-2-ol, ethylene glycol, and ethyl acetate) was measured using the gravimetric method from 283.15 to 323.15 K at atmospheric pressure. The optimization of the complexes between VA–solvents and V–solvents using the B3LYP theoretic technique and the 6-31+G (d, p) basis set indicated that the absolute value of interaction energy was higher, suggesting that the interaction between solute and the solvent was stronger. In addition, two excellent activity coefficient models (NRTL and Wilson) were used to correlate and evaluate the equilibrium solubility results. The highest relative average deviation and root-mean-square deviation values for VA are 4.36% and 3.09 × 10-3, respectively, and 3.35% and 5.52 × 10-3 for V. Furthermore, the excess enthalpy of the solution was determined on the basis of thermodynamic relations and the Wilson model. The findings indicate that the dissolution process was endothermic.
KEY WORDS: Solid-liquid equilibrium, Vanillin, Vanillic acid, NRTL and Wilson models, Thermodynamic parameters
Bull. Chem. Soc. Ethiop. 2024, 38(3), 799-810.
DOI: https://dx.doi.org/10.4314/bcse.v38i3.19
Experimental and rheological modelling on the stabilization of iron ore slurry using a biosurfactant extracted from Aloe barbadensis Miller
Authors: Narayan Das Subrata , K. Biswal Susanta , Behera Ajit , Belbsir Hamza , El-Hami Khalil , K. Mohapatra Ranjan 
Published: March 2024

The pipeline transportation of iron ore slurry (IOS) is an eco-friendly alternate mode to transport the raw materials to longer distance and reduce the transportation network congestion problems. Proper selection of surfactant could modify mineral’s viscosity, dispersion and wetting characteristics effectively as may be desired, which may further be monitored. A surfactant alters surface characteristics after being adsorbed onto minerals by altering the interfacial behaviour. This work is first report of the influence of a biosurfactant sourced from Aloe barbadensis Miller on the rheological behaviour of a high-grade iron ore (IO) sample at 45–72% by mass slurry concentrations range. The observed rheological parameters confirmed the non-Newtonian flow behaviour of the slurry. The collected IO and dried IOS samples were subjected to UV-Vis, XRF, PSD, XRD, SEM and EDS analyses. Experimental rheological data at varying concentrations was tested on various models to ascertain the best-fit rheological model for IOS transport. The Bingham model was found to be the most suitable to model the rheology of IOS. Experimental rheological behaviour of IOS was found to be linear with the yield stress. The study shall help to ascertain the suitability of a biosurfactant to stabilise high grade iron ores for pipeline transportation.
KEY WORDS: Iron ore slurry, Aloe barbadensis, Rheological measurements, Rheological modelling
Bull. Chem. Soc. Ethiop. 2024, 38(3), 615-629.
DOI: https://dx.doi.org/10.4314/bcse.v38i3.6
Essai clinique d’un programme d’intervention en lecture pour les lecteurs en difficulté issus de divers milieux sociodémographiques à Ibadan, dans l’État d’Oyo, au Nigéria
Authors: Ashike Orim Matthew , Regec Vojtec , Edim Assam Andy 
Published: March 2024

Cette étude a examiné l’efficacité du programme READ (Reading for Educational Advancement and Development) en tant qu’intervention de lecture pour les lecteurs en difficulté à Ibadan, dans l’État d’Oyo. Elle a également étudié les effets modérateurs du statut socio-économique et du niveau d’éducation des parents dans les associations en raison de la diversité sociodémographique de la zone d’étude. Deux hypothèses ont été formulées et testées à un niveau de signification de 0,05. Un plan factoriel 2x2x2 pré-test post- test a été utilisé. Le statut socio-économique et le niveau d’éducation des parents, tous à 2 niveaux, ont modéré les associations. Un échantillon de 25 participants a été exposé au traitement utilisant le programme READ, tandis que les 26 autres ont été exposés au traitement placebo, le tout pendant 16 semaines. Les données recueillies ont été analysées à l’aide de l’ANCOVA. Des améliorations ont été constatées dans les résultats obtenus après le traitement au test d’aptitude à la lecture, indiquant une amélioration de la lecture orale, de la compréhension, du vocabulaire et de l’orthographe dans le groupe de traitement par rapport au groupe de comparaison, en utilisant l’ANOVA. Il a également été démontré que le statut socio-économique (F (1/16) = 0,704, p > 0,05, 2= 0,051) et le niveau d’éducation des parents (F (1/16) = 0,022, p > 0,05, 2= 0,001) modéraient les associations. Il a été conclu que READ est une intervention thérapeutique efficace pour les lecteurs en difficulté issus de divers milieux sociodémographiques. Sa formation et son utilisation sont recommandées aux écoles et aux enseignants.
Implementasi Metode Chinese Remainder Theorem Untuk Menyisipkan Citra Digital Kedalam File Video
Authors: Purba Christin Oktaria 
Published: March 2024

Hal yang paling penting pada media teknologi saat ini adalah keamanan data atau informasi. Citra digital adalah salah satunya data yang visual yang banyak disalahgunakan oleh pihak yang tidak bertanggungjawab. Oleh karean itu dibutuhkan suatu wadah tempat citra digital tersebut disisipkan agar dapat terhindar dari orang yang akan menyalahgunakan citra tersebut. Seni untuk dapat menyisipkan data atau informasi ke dalam suatu media penampung seperti gambar, video, audio, dan teks adalah teknik steganografi yang akan membuat orang yang melihat atau menerima data atau informasi tidak menyadari ada informasi penting di dalamnya. Oleh karena itu diperlukan perangkat lunak untuk menyisipkan sebuah informasi penting yaitu citra digital ke dalam wadah penampung yaitu file video. Pemilihan file video sebagai wadah penampung dalam penyisipan citra membutuhkan metode yang tepat. Metode yang digunakan dalam proses penyisipan adalah chinese remainder theorem. Meningkatkan keamanan serta kompleksitas komputasi rendah adlah keuntungan dari metode chinese remaninder theorem
Perbandingan Metode Dematel Dan Edas Pada Pemilihan Karyawan Kerok Terbaik
Authors: Zai Winda Ningsi 
Published: March 2024

Swallow is one of the local products that are in great demand by entrepreneurs in the city of Medan for cultivation of PT. Efyanto walet as a limited company engaged in the trade and services of Swallow distributors has a very important role in meeting the needs of consumer demand for the availability of swallow nests. Common problems that often occur when selecting the best employees are often there is a lack of transparency, undocumented exposure to the criteria value used by both selectors, and there is still a lot of discrimination found. With the decision support system to get the best alterntif results from problems that often occur. Therefore, the method used is the Dematel and Edas methods thus carried out the establishment of both methods for the right solution to solve the problem.
DEPURACIÓN DE AGUA CONTAMINADA CON HIDROCARBUROS EN EL RÍO RUMIYACU, MEDIANTE HUMEDALES ARTIFICIALES EN LA PROVINCIA DE FRANCISCO DE ORELLANA
Authors: Heredia Moyano Sandra , Gavilanes Montoya Alex , Heredia Moyano María Fernanda 
Published: March 2024

La construcción de humedales artificiales para el tratamiento de aguas provenientes de cuerpos hídricos como el Río Rumiyacu, tiene como propósito disminuir la cantidad de contaminantes orgánicos e inorgánicos de ecosistemas lóticos mediante procesos primarios, tales como la sedimentación, degradación enzimática, absorción y volatilización de compuestos. En este proceso de biorremediación se emplearon especies vegetales (gramíneas) de la zona como: Echynochloa polystachya, Pennisetum purpureum, Panicum máximum, y Arvenses sp. Se determinó el caudal hídrico (0,58 m3/s) por el método del flotador, y mediante un muestreo compuesto (alícuotas) se diseñaron los humedales. Se aplicó la prueba estadística de análisis de varianzas (ANOVA) para determinar las especies de mayor remoción de contaminantes como: níquel, hierro, demanda química de oxígeno, demanda bioquímica de oxígeno, coliformes totales e hidrocarburos totales de petróleo. En su conjunto, la remoción de cargas contaminantes representa el 44,53%, en dependencia de las diferentes eficiencias de cada especie en cada parámetro, por lo que, se recomienda monitorear y evaluar ambientalmente a los tributarios del río.
The Enhanced Recovery After Surgery (ERAS) for Patients Undergoing Planned Abdomino-Pelvic Surgery: Recovering Bowel Motility and Reducing Length of Stay
Authors: Shagufta Parveen  , Rubaba Abid Naqvi  , Mahwash Jamil  , Nabila Irum  
Published: March 2024

Objective: To evaluate the effectiveness of chewing gum in improving paralytic ileus, shortening hospital stays, and enhancing satisfaction in patients undergoing planned abdomino-pelvic surgery.
Methodology: A quasi-experimental study with a non-equivalent groups design was conducted in the Obstetrics and Gynecology department of Rawalpindi Teaching Hospital from January 15, 2023, to July 15, 2023. One hundred and fifty eight patients were randomly assigned to two groups: Group A (gum chewing) and Group B (control), each containing 79 patients. Group A was instructed to chew gum for 15 minutes three times a day starting 6 hours after surgery. Group B received conservative management, commencing clear oral fluids after the passage of gas and transitioning to a soft diet after passing stool. The primary outcome measures included the time to first bowel sounds, passage of flatus, passage of stool, and length of hospital stay, while secondary outcome measures comprised nausea, vomiting, patient satisfaction, and abdominal distension.
Results: The average age in Group A was 48.6 ± 10.9, and in Group B it was 50.2 ± 13.7. The mean post-operative time (in hours) to audible bowel sounds in Group A and B was 49 (43-63) versus 61 (46-72), respectively (P=0.03); passage of flatus was 70 (50-83) versus 80 (67-110) (P=0.01); stool passage was (38.1 ± 29.8 versus 58.25 ± 18.6) (P=0.002); and hospital stay was 71 (56-89) versus 93 (75-118) (P<0.001).
Conclusion: Gum chewing after elective abdomino-pelvic surgery enhances post-operative recovery by promoting early bowel function and thereby reducing hospital stays.
ABORDAGEM DO HTLV-2 EM POVOS ORIGINÁRIOS DA REGIÃO AMAZÔNICA: UMA REVISÃO NARRATIVA
Authors: Silva Klayrê Martins Araujo e , Tasca Nayara Fernanda Nazareno , Santos Ana Cristina Doria dos 
Published: March 2024

Os vírus linfotrópicos de células T humanas (HTLV), também conhecidos como Human T-cell lymphotropic viruses, formam um conjunto de retrovírus inseridos na família Retroviridae, subfamília Orthoretrovirinae e gênero Deltaretrovirus. Esta classe de vírus pode ser classificada em quatro tipos principais: HTLV-1, HTLV-2, HTLV-3 e HTLV-4. O HTLV 2 resulta da transmissão de linfócitos infectados que estão presentes em uma variedade de fluidos corporais, abrangendo sangue, sêmen, secreção vaginal e leite materno. A presença da infecção por HTLV-1/2 é global e se concentram em áreas geográficas delimitadas por regiões que não são endêmicas. Estima-se que a quantidade de indivíduos infectados pelo HTLV-1 no mundo seja de aproximadamente de dez a 20 milhões; foi constatado que o HTLV-2 é endêmico em populações Ameríndias e, especificamente, entre os grupos originários da Amazônia brasileira, que é a região com maior prevalência para esse vírus. Uma preocupação notável é a insuficiência no rastreamento, subnotificação e a falta de abrangência em estudos sobre os impactos do HTLV- 2 na saúde das populações originárias, especialmente nas comunidades indígenas localizadas na região da Amazônia brasileira.
MARSUPIALIZAÇÃO DE RÂNULA: UM RELATO DE CASO CLÍNICO
Authors: Santiago  Arthur Mariano de Oliveira , Pereira Ana Giselly Soares , Ferreira Isabella Gaio , Silva Maria Carollyne Santos , Ugarte Rodrigo Gonzalo Valdivia , Araújo Fábio Andrey da Costa 
Published: March 2024

Introdução: As rânulas são mucoceles que ocorrem na região submandibular, sua etiologia geralmente é um trauma no local do aparecimento da lesão ou obstrução do canal de uma glândula, é comum ocorrer um extravasamento de mucina para os tecidos moles circundantes. Objetivo: Este trabalho tem como objetivo relatar um caso de rânula no assoalho de boca em paciente de 27 anos de idade, que compareceu ao departamento de cirurgia do Hospital Universitário Oswaldo Cruz relatando uma lesão que aumentava de volume e estourava, com recorrência. Conclusão: A marsupialização da rânula foi o tratamento de escolha para o caso. Após o procedimento, é fundamental que o paciente seja acompanhado para garantir a efetividade do tratamento e proporcionar um melhor prognóstico.
Palavras-chave: Mucocele, Rânula, Patologia bucal.