bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanosafety: a Perspective on Nano‐Bio Interactions
Authors: Fadeel Bengt , Keller Arturo A. 
Published: April 2024

AbstractEngineered nanomaterials offer numerous benefits to society ranging from environmental remediation to biomedical applications such as drug or vaccine delivery as well as clean and cost‐effective energy production and storage, and the promise of a more sustainable way of life. However, as nanomaterials of increasing sophistication enter the market, close attention to potential adverse effects on human health and the environment is needed. Here a critical perspective on nanotoxicological research is provided; the authors argue that it is time to leverage the knowledge regarding the biological interactions of nanomaterials to achieve a more comprehensive understanding of the human health and environmental impacts of these materials. Moreover, it is posited that nanomaterials behave like biological entities and that they should be regulated as such.
Nickel Oxide Hole Injection Layers for Balanced Charge Injection in Quantum Dot Light‐Emitting Diodes
Authors: Wan Haoyue , Jung Eui Dae , Zhu Tong , Park So Min , Pina Joao M. , Xia Pan , Bertens Koen , Wang Ya‐Kun , Atan Ozan , Chen Haijie , Hou Yi , Lee Seungjin , Won Yu‐Ho , Kim Kwang‐Hee , Hoogland Sjoerd , Sargent Edward H. 
Published: April 2024

AbstractQuantum dot (QD) light‐emitting diodes (QLEDs) are promising for next‐generation displays, but suffer from carrier imbalance arising from lower hole injection compared to electron injection. A defect engineering strategy is reported to tackle transport limitations in nickel oxide‐based inorganic hole‐injection layers (HILs) and find that hole injection is able to enhance in high‐performance InP QLEDs using the newly designed material. Through optoelectronic simulations, how the electronic properties of NiOx affect hole injection efficiency into an InP QD layer, finding that efficient hole injection depends on lowering the hole injection barrier and enhancing the acceptor density of NiOx is explored. Li doping and oxygen enriching are identified as effective strategies to control intrinsic and extrinsic defects in NiOx, thereby increasing acceptor density, as evidenced by density functional theory calculations and experimental validation. With fine‐tuned inorganic HIL, InP QLEDs exhibit a luminance of 45 200 cd m−2 and an external quantum efficiency of 19.9%, surpassing previous inorganic HIL‐based QLEDs. This study provides a path to designing inorganic materials for more efficient and sustainable lighting and display technologies.
Laser‐Induced Graphene‐Based Sensors in Health Monitoring: Progress, Sensing Mechanisms, and Applications
Authors: Li Zihao , Huang Libei , Cheng Le , Guo Weihua , Ye Ruquan 
Published: April 2024

AbstractThe rising global population and improved living standards have led to an alarming increase in non‐communicable diseases, notably cardiovascular and chronic respiratory diseases, posing a severe threat to human health. Wearable sensing devices, utilizing micro‐sensing technology for real‐time monitoring, have emerged as promising tools for disease prevention. Among various sensing platforms, graphene‐based sensors have shown exceptional performance in the field of micro‐sensing. Laser‐induced graphene (LIG) technology, a cost‐effective and facile method for graphene preparation, has gained particular attention. By converting polymer films directly into patterned graphene materials at ambient temperature and pressure, LIG offers a convenient and environmentally friendly alternative to traditional methods, opening up innovative possibilities for electronic device fabrication. Integrating LIG‐based sensors into health monitoring systems holds the potential to revolutionize health management. To commemorate the tenth anniversary of the discovery of LIG, this work provides a comprehensive overview of LIG's evolution and the progress of LIG‐based sensors. Delving into the diverse sensing mechanisms of LIG‐based sensors, recent research advances in the domain of health monitoring are explored. Furthermore, the opportunities and challenges associated with LIG‐based sensors in health monitoring are briefly discussed.
Calculation of the mechanical properties of high‐performance concrete employing hybrid and ensemble‐hybrid techniques
Authors: Zhang Leilei , Zhao Yuwei 
Published: April 2024

AbstractThis study aims to execute machine learning methods to predict the mechanical properties containing TS and CS of HPC. They are essential parameters for the durability, workability, and efficiency of concrete structures in civil engineering. In this regard, obtaining the estimation of the mechanical properties of HPC is complex energy and time‐consuming. Due to this, an observed database was compiled, including 168 datasets for CS and 120 for TS. This database trained and validated two machine learning models: SVR and RT. The models combine the prediction outputs from the meta‐heuristic algorithms to build hybrid and ensemble‐hybrid models, which include dwarf mongoose optimization, PPSO, and moth flame optimization. According to the observed outputs, the ensemble models have great potential to be a recourse to deal with the overfitting problem of civil engineering, thus leading to the development of more supportable and less polluting concrete structures. This research significantly improves the efficiency and accuracy of predicting vital mechanical properties in high‐performance concrete by integrating machine learning and metaheuristic algorithms, offering promising avenues for enhanced concrete structure design and development.
Impact of herd mobility on brucellosis seroprevalence and spread risk resulting from cross‐border transhumance
Authors: Oyetola Wilfried Délé , Daou Samba , Bonfoh Bassirou , Bada Alambedji Rianatou 
Published: April 2024

AbstractBackgroundCross‐border livestock mobility through transhumance is mainly practiced in West African countries for seasonal access to resources and market. Cross‐border herds are involved in the dynamic of transboundary animal diseases among them brucellosis taken as model. Brucellosis is a zoonotic disease causing abortion.ObjectivesThis study explores the seroprevalence of brucellosis according to mobility and infection spread between Mali and Côte d'Ivoire in the context of seasonal cross‐border transhumance.MethodsFrom February to April 2021, a transversal serological survey of brucellosis was conducted on 521 cattle from 111 transhumant herds and 283 cattle from 59 sedentary herds, all from Mali.ResultsThe global individual seroprevalence for Brucella spp. in transhumant and sedentary cattle from Mali was 8.2% (95% CI = 6.0–10.5). At herd level, seroprevalence was 21.2% with a significant variation between transhumant (11.7%) and sedentary (39.0%) herds. For herds in transhumance, cattle seropositivity was associated with a previous infection suspected by herdsmen odds ratio (OR = 4.4; 95% CI = 1.1–18.1) and unknown abortion aetiology (OR = 4.3; 95% CI = 1.0–17.3). The departure region (coming from Sikasso) and previous brucellosis infection or unexplained abortion could be used to predict Brucella infection in transhumant herds with a probability of around 60%. The risk of brucellosis introduction in host regions was high despite the individual animal seroprevalence of 3.6% and a low sale rate in transhumant cattle.ConclusionsThe findings suggest that testing transhumant during border control and survey of cattle markets and sales could improve risk control of the spread of disease at regional scale.
A mass balance approach for quantifying the role of natural decay and fate mechanisms on SARS‐CoV‐2 genetic marker removal during water reclamation
Authors: Carine Madeline R. , Pagilla Krishna R. 
Published: April 2024

AbstractThe recent SARS‐CoV‐2 outbreak yielded substantial data regarding virus fate and prevalence at water reclamation facilities (WRFs), identifying influential factors as natural decay, adsorption, light, pH, salinity, and antagonistic microorganisms. However, no studies have quantified the impact of these factors in full scale WRFs. Utilizing a mass balance approach, we assessed the impact of natural decay and other fate mechanisms on genetic marker removal during water reclamation, through the use of sludge and wastewater genetic marker loading estimates. Results indicated negligible removal of genetic markers during P/PT (primary effluent (PE) p value: 0.267; preliminary and primary treatment (P/PT) accumulation p value: 0.904; and thickened primary sludge (TPS) p value: 0.076) indicating no contribution of natural decay and other fate mechanisms toward removal in P/PT. Comparably, adsorption and decomposition was found to be the dominant pathway for genetic marker removal (thickened waste activated sludge (TWAS) log loading 9.75 log10 GC/day); however, no estimation of log genetic marker accumulation could be carried out due to high detections in TWAS.Practitioner Points
The mass balance approach suggested that the contribution of natural decay and other fate mechanisms to virus removal during wastewater treatment are negligible compared with adsorption and decomposition in P/PT (p value: 0.904).
During (P/PT), a higher viral load remained in the (PE) (14.16 log10 GC/day) compared with TPS (13.83 log10 GC/day); however, no statistical difference was observed (p value: 0.280) indicting that adsorption/decomposition most probably did not occur.
In secondary treatment (ST), viral genetic markers in TWAS were consistently detected (13.41 log10 GC/day) compared with secondary effluent (SE), indicating that longer HRT and the potential presence of extracellular polymeric substance‐containing enriched biomass enabled adsorption/decomposition.
Estimations of total solids and volatile solids for TPS and TWAS indicated that adsorption affinity was different between solids sampling locations (p value: <0.0001).
Documentation of Engraftment and Chimerism After HCT
Authors: Bader Peter , Kreyenberg Hermann , Bacigalupo Andrea 
Published: April 2024

AbstractIt is of central interest to document that the newly developing hematopoiesis post-transplant is of donor or recipient origin. The investigations of the genotype origin of post-transplant hematopoiesis are called chimerism analysis. The term “chimerism” was first introduced into medicine in 1951. Andresen wrote that an organism with cells from two or more distinct zygote lineages is a “chimera.” Since 1956, this term was used in field of transplantation (Ford et al. Nature 177:452–4, 1956). Chimera refers itself to the Greek mythology where Homer described a fire-spitting monster with the head of a lion, a tail of a serpent, and the body of a goat terrorizing Lycia, a region in Minor Asia.
Psychological Morbidity and Care
Authors: Polomeni Alice , Scherwath Angela 
Published: April 2024

AbstractThe growing scientific knowledge in the field of allogeneic hematopoietic cell transplantation (alloHCT) has enabled a greater number of patients to access this curative therapy. However, advances in alloHCT such as the expansion of treatment indications and the age of eligible patients, new preemptive protocols and the development of haploidentical transplantation raise new ethical and clinical questions.
The HCT Unit
Authors: Rasheed Walid , Niederwieser Dietger W. , Aljurf Mahmoud 
Published: April 2024

AbstractHematopoietic cell transplantation (HCT) is an advanced therapeutic intervention that is required for a number of malignant and nonmalignant medical conditions, often for critically ill patients. The establishment of an HCT program requires the efforts of experienced and appropriately trained personnel to lead the program. Clearly, this also requires financial, legal, ethical, and other institutional support. Without the commitment of the hospital director, allocation of resources, support of the national health authorities, and politicians, an HCT program will not be successful. For newly starting programs, it would be essential to identify minimal requirements for establishing an HCT unit in order to optimize resource utilization as well as maintain safe patient care. While these minimal requirements also apply to well-established units, its structure helps to understand and implement additional steps for larger units which plan to offer additional transplant services and have access to more resources. The recent advent of more cellular therapy types, including immune effector cell therapy, has added another layer of complexity necessitating additional requirements by HCT programs to ensure patient safety.
Posttransplant Lymphoproliferative Syndromes
Authors: Styczynski Jan , Giebel Sebastian 
Published: April 2024

AbstractPosttransplant lymphoproliferative disorders (PTLD) constitute a heterogeneous group of lymphoproliferative diseases that occur in the setting of transplantation and result from the uncontrolled neoplastic proliferation of lymphoid or plasmacytic cells in the context of extrinsic immunosuppression after transplantation.
Hepatic Complications
Authors: Carreras Enric , Ruutu Tapani , Mohty Mohamad , Corbacioglu Selim , de la Cámara Rafael 
Published: April 2024

AbstractThe frequency and severity of hepatic complications during hematopoietic cell transplantation (HCT) markedly decreased in the last decade, thanks to improvements in preventive and therapeutic measures for most frequent complications, as fungal infections, hepatotropic viruses, sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD), hepatic graft-versus-host disease (GVHD), and improved management of hepatotoxic drugs and iron overload (Hockenbery et al. 2016).
JACIE Accreditation of HCT Programs
Authors: Saccardi Riccardo , Rintala Tuula , McGrath Eoin , Snowden John A. 
Published: April 2024

AbstractThe complexity of HCT as a medical technology and the frequent need for close interaction and interdependence between different services, teams, and external providers (donor registries, typing laboratories, etc.) distinguish it from many other medical fields. This complexity led to efforts by transplantation professionals to standardize processes based on consensus as a way to better manage inherent risks of this treatment. HCT was, and continues to be, a pioneer in the area of quality and standards.
Gastrointestinal Complications
Authors: Basak Grzegorz W. 
Published: April 2024

AbstractThe gastrointestinal (GI) tract is one of the systems most commonly affected by transplant complications. It is due to the high vulnerability of the gut mucosa composed of dividing cells, which are susceptible to chemotherapy-induced damage, rich vasculature, constant contact with intestinal microflora, and high content of immune-competent cells.
Cardiovascular Diseases and Metabolic Syndrome
Authors: Galvan Elisa Roldan , Snowden John A. , Greenfield Diana M. 
Published: April 2024

AbstractAn increased incidence of cardiovascular disease (CVD) has been shown after HCT, either autologous or allogeneic, compared with the normal population, with a cumulative incidence of cardiovascular events 15 years after HCT up to 6%. Screening of all patients who undergone an HCT is recommended in the international consensus guidelines. Knowing the risk factors and management of these complications and working with a multidisciplinary approach is essential to ensure the appropriate care of these patients.
Biological Properties of Hematopoietic Stem Cells: Scientific Basis for Hematopoietic Cell Transplantation
Authors: Aiuti Alessandro , Scala Serena , Chabannon Christian 
Published: April 2024

AbstractHematopoiesis—from the Greek term for “blood making”—is the adaptive process by which mature and functional blood cells are continuously replaced over the entire lifetime of an individual. Erythrocytes, platelets, and the various subsets of leukocytes all have finite although different life spans. As a consequence, the daily production of red blood cells, platelets, and neutrophils under homeostatic conditions amounts to more than 300 billion cells.
AML in Adults
Authors: Versluis Jurjen , Cornelissen Jan J. , Craddock Charles , Sanz Miguel Á. , Nagler Arnon 
Published: April 2024

AbstractAML is a malignancy of hematopoietic immature precursors (myeloblasts) that accumulate in the BM at the expense of their normal counterparts. AML is increasingly being recognized as a heterogenous malignancy based on distinct disease biology and underlying cytogenetic and molecular profiles. These profiles and measurable residual disease after induction therapy direct post-remission strategies in a risk-adapated approach, which also includes the assessment of the risk of treatment-related mortality. In primary refractory AML, allo-HSCT remains a curative treatment option in fit patients. Allo-HSCT in acute promyelocytic leukemia is only recommended for specific cases, particularly when not in moleculair remission after treatment for first relapse.
Biological Properties of Cells Other Than HSCs
Authors: Bondanza Attilio , Koehl Ulrike , Hoffmann Andrea , Toubert Antoine 
Published: April 2024

AbstractThe array of cellular players involved in the biology of hematopoietic cell transplantation (HCT) clearly extends beyond hematopoietic stem cells (HSCs) themselves and, in the case of transplantation from allogeneic sources, importantly includes cells of the innate and adaptive immune systems. Historically, the discovery of the human leukocyte antigen (HLA) system and the functional characterization of the different immune cell types had a transformational impact on our current understanding of the pathobiological “sequelae” of allo-HCT (rejection, graft-versus-host disease (GVHD), graft-versus-leukemia (GVL) effect). This body of knowledge coupled to the most recent “exploitation” of biotechnology has allowed us to design strategies for in vivo stimulation or adoptive transfer of specific immune cell types with the potential to dramatically improve transplantation outcome.
Introduction
Authors: Sawer Marian , Maley Maria 
Published: April 2024

AbstractAlmost 100 years after the arrival of women in the masculine domain of parliament they began breaking the silence about sexual harassment and bullying they experienced. This chapter introduces concepts relating to this experience, including toxic parliaments, sexual and sex-based harassment and bullying, as well as the broader concept of violence against women in politics and its disproportionate impact on those from minority backgrounds. Characteristics particularly associated with Westminster parliaments such as adversarialism and conventions of parliamentary privilege are briefly introduced, along with the distinctive nature of the parliamentary workforce. Feminist institutionalism provides the theoretical framework for the overall argument—that in Australia parliamentary reform took longer than in other Westminster parliaments but that a combination of timing and local mobilisation created a critical juncture and powerful momentum. The chapter ends with an overview of the rest of the book.
When a Phenomenon-Based University Course Went Online: Students’ Experiences and Reflections After Sauna Bathing
Authors: Wolff Lili-Ann , Heikkilä Emma , Wallinheimo Kirsi , Blomberg Wilhelm 
Published: April 2024

AbstractThis chapter presents and discusses results from data in form of learning diaries that a group of Finnish students wrote on a distance university course arranged during the COVID-19 lockdown. Initially, the course was planned to take place at a World Heritage site, but because of the pandemic, it had to be released online, and in the students’ own outdoor surroundings with limited physical interaction between the students. The first version of the course was run before the COVID-19pandemic, but it had to be totally modified first to an online version, and then to a hybrid version during the pandemic restrictions. For this reason, the World Heritage site as learning environment and focus had to quickly incorporate a current Finnish Cultural Heritage, the sauna bathing culture, in the course. The students were instructed to write or record their diaries in the form of stream of consciousness after their sauna bathing or other bathing, and these diaries were used as data in our study. The theoretical approach of the study is phenomenology, and we analysed the diaries employing hermeneutic/interpretative phenomenology. The result shows that the sauna diaries were a successful course element that made it possible for the students to express themselves and reflect on their daily lives in a critical situation, but also to reflect deeply on the course, and their own role in that context.
Changes in treatment of intracranial aneurysms during the last decade in a large European neurovascular center
Authors: Calvanese Francesco , Auricchio Anna Maria , Pohjola Anni , Hafez Ahmad , Nurminen Ville , Korja Miikka , Numminen Jussi , Lehecka Martin , Raj Rahul , Niemelä Mika 
Published: April 2024

Abstract

Objective
Treatment modality for ruptured and unruptured intracranial aneurysms has shifted during the last two decades from microsurgical treatment towards endovascular treatment. We present how this transition happened in a large European neurovascular center.

Methods
We conducted a retrospective observational study consecutive patients treated for an unruptured or ruptured intracranial aneurysm at Helsinki University Hospital during 2012–2022. We used Poisson regression analysis to report age-adjusted treatment trends by aneurysm location and rupture status.

Results
A total of 2491 patients with intracranial aneurysms were treated (44% ruptured, 56% unruptured): 1421 (57%) surgically and 1070 (43%) endovascularly. A general trend towards fewer treated aneurysms was noted. The proportion of patients treated surgically decreased from 90% in 2012 to 20% in 2022. The age-adjusted decrease of surgical versus endovascular treatment was 6.9%/year for all aneurysms, 6.8% for ruptured aneurysms, and 6.8% for unruptured aneurysms. The decrease of surgical treatment was most evident in unruptured vertebrobasilar aneurysms (10.8%/year), unruptured communicating artery aneurysms (10.1%/year), ruptured communicating artery aneurysms (10.0%/year), and ruptured internal carotid aneurysms (9.0%/year). There was no change in treatment modality for middle cerebral artery aneurysms, of which 85% were still surgically treated in 2022. A trend towards an increasing size for treated ruptured aneurysms was found (p = 0.033).

Conclusion
A significant shift of the treatment modality from surgical to endovascular treatment occurred for all aneurysm locations except for middle cerebral artery aneurysms. Whether this shift has affected long-term safety and patient outcomes should be assessed in the future.