bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual‐Track Multifunctional Bimetallic Metal‐Organic Frameworks for Antibiotic Enrichment and Detection
Authors: Dong Yiming , Feng Niu , Liu Puyue , Wei Qiaoling , Peng Xuewen , Jiang Feng , Chen Yiping 
Published: April 2024

AbstractThe improper use and overuse of antibiotics have led to significant burdens and detrimental effects on the environment, food supply, and human health. Herein, a magnetic solid‐phase extraction program and an optical immunosensor based on bimetallic Ce/Zr‐UiO 66 for the detection of antibiotics are developed. A magnetic Fe3O4@SiO2@Ce/Zr‐UiO 66 metal‐organic framework (MOF) is prepared to extract and enrich chloramphenicol from fish, wastewater, and urine samples, and a horseradish peroxidase (HRP)‐Ce/Zr‐UiO 66@bovine serum protein‐chloramphenicol probe is used for the sensitive detection of chloramphenicol based on the dual‐effect catalysis of Ce and HRP. In this manner, the application of Ce/Zr‐UiO 66 in integrating sample pretreatment and antibiotic detection is systematically investigated and the associated mechanisms are explored. It is concluded that Ce/Zr‐UiO 66 is a versatile dual‐track material exhibiting high enrichment efficiency (6.37 mg g−1) and high sensitivity (limit of detection of 51.3 pg mL−1) for chloramphenicol detection and serving as a multifunctional MOF for safeguarding public health and hygiene.
The Nanoscale Structure and Stability of Organic Photovoltaic Blends Processed with Solvent Additives
Authors: Kilbride Rachel C. , Spooner Emma L. K. , Burg Stephanie L. , Oliveira Bárbara L. , Charas Ana , Bernardo Gabriel , Dalgliesh Robert , King Stephen , Lidzey David G. , Jones Richard A. L. , Parnell Andrew J. 
Published: April 2024

AbstractControlling the nanomorphology in bulk heterojunction photoactive blends is crucial for optimizing the performance and stability of organic photovoltaic (OPV) technologies. A promising approach is to alter the drying dynamics and consequently, the nanostructure of the blend film using solvent additives such as 1,8‐diiodooctane (DIO). Although this approach is demonstrated extensively for OPV systems incorporating fullerene‐based acceptors, it is unclear how solvent additive processing influences the morphology and stability of nonfullerene acceptor (NFA) systems. Here, small angle neutron scattering (SANS) is used to probe the nanomorphology of two model OPV systems processed with DIO: a fullerene‐based system (PBDB‐T:PC71BM) and an NFA‐based system (PBDB‐T:ITIC). To overcome the low intrinsic neutron scattering length density contrast in polymer:NFA blend films, the synthesis of a deuterated NFA analog (ITIC‐d52) is reported. Using SANS, new insights into the nanoscale evolution of fullerene and NFA‐based systems are provided by characterizing films immediately after fabrication, after thermal annealing, and after aging for 1 year. It is found that DIO processing influences fullerene and NFA‐based systems differently with NFA‐based systems characterized by more phase‐separated domains. After long‐term aging, SANS reveals both systems demonstrate some level of thermodynamic induced domain coarsening.
Deprotonated of layered double hydroxides during electrocatalytic water oxidation for multi‐cations intercalation
Authors: Jin Bowen , Gao Jianxiong , Zhang Yunqi , Shao Mingfei 
Published: April 2024

AbstractAqueous rechargeable batteries using abundant multi‐ion cations have received increasing attention in the energy storage field for their high safety and low cost. Layered double hydroxides (LDHs) possess a two‐dimensional structure and exhibit great potential as cathodes for multi‐ion intercalation. However, the insufficient active sites of LDHs result in low capacities in the discharging process. Interestingly, the LDHs after the deprotonation process exhibit favorable electrochemical performance of multi‐cation intercalation. The deprotonation process of LDHs has been widely found in the oxygen evolution reaction and energy storage field, where LDHs lose H in laminates and converts to deprotonated γ‐phase MOOHs (MOOs). Herein, we take a comprehensive overview of the dynamics structure transformation of the deprotonation process of LDHs. Furthermore, the development of advanced aqueous battery cathode and metal battery anode based on deprotonated LDHs for energy storage is explored and summarized. Finally, the perspective of deprotonated LDHs in the energy storage field is discussed.
Phosphorus recycling and loss from compost‐amended urban gardens: Results from a 7‐year study
Authors: Small Gaston E. , Shrestha Paliza , Zeiner Carolyn , Barabás György , Metson Geneviève Suzanne 
Published: April 2024

AbstractUrban vegetable gardens provide an opportunity to recycle nutrients from food waste back into the human food system through the application of compost. However, a reliance on compost for soil fertility can lead to excess phosphorus (P) inputs that can build up in garden soil and potentially be exported via leachate or runoff. We report the results of a 7‐year experiment in a campus research garden in which replicated raised‐bed garden plots received manure‐based compost or municipal compost that was applied at a higher rate targeted to meet crop nitrogen demand or a lower rate targeted to meet crop P demand. Control plots received either no soil inputs or targeted synthetic fertilizer. Higher input treatments for both types of composts showed steadily increasing concentrations of soil plant‐available P, with a corresponding increase in leachate phosphate concentration. For both higher input compost treatments, approximately 30% of P added as compost was recovered in harvested crops over the 7‐year period, compared to >88% in the lower input compost treatments. In both high‐ and low‐input manure compost treatments, export of P as leachate accounted for approximately 10% of total P input, compared to 4% for the municipal compost. Over the 7‐year study period, P exported as leachate ranged from 0.8 g P/m2 in the no‐input treatments to 6.5 g P/m2 in the higher input manure compost treatments. These results show that tradeoffs are not inevitable as targeted compost applications can lead to high yield and low leachate export.
Seasonal investigation of the macroscopic and microscopic structure of the sinus interdigitalis in Hamdani crossbred sheep (Ovis aries)
Authors: Işbilir Fatma , Özgüden Akkoç Cansel Güzin , Kirman Günsel , Özöner Özgür , Özöner Merve Pekince , Işbilir Ihsan , Gülendağ Erman , Gülaydin Ali , Arican İlker 
Published: April 2024

AbstractBackgroundThe odours of different body parts and structures, such as external genitalia, female urine, ventral tail radix, infraorbital sinus and interdigital sinus, have a strong attractiveness for rams. The sinus interdigitalis is considered an important trail gland for sexual behaviour, as its odour is included in the list of strongly attractive structures for male animals during the breeding season, being important in pheromone production.ObjectivesIn the present study, the effects of sex and breeding season on the morphological and histological structure of the interdigital gland were investigated in Hamdani crossbred sheep (Ovis aries).MethodsSinus interdigitalis glands located on the forelimbs and hind limbs were collected from 10 male and 10 female sheep during both breeding and non‐breeding seasons. The gland's position in the forelimbs and hind limbs was determined radiographically. The glands were examined macroscopically, histologically and immunohistochemically in both seasons.ResultsIn all animals, the topographic location of the gland between the digits was determined to be distal to the phalanx proximalis and at the level of the phalanx media. The mean weight of the gland in male and female animals was 1.07 ± 0.03 and 1.4 ± 0.11 g, respectively. In general, the results of morphometric measurements were higher during the breeding season, and the increase was more pronounced in female animals. In histological examinations, it was determined that both neck and body parts of the tissues consisted of a structure consisting of a connective tissue capsule at the outermost, dermis, epidermis and lumen underneath. Immunohistochemically staining revealed that oestrogen receptors showed positive immunoreactions only in the intracytoplasmic localization of apocrine sweat glands. In terms of morphological, histological and oestrogen receptors, it was thought that the gland may play a role in sexual communication.
Suspected multiple autoimmune syndrome in a Kelpie with hypoadrenocorticism
Authors: Cleary Kimberly 
Published: April 2024

AbstractAn 8‐year‐old, female, spayed Kelpie cross presented with hyporexia, pica, vomiting, collapse and seizures. It was diagnosed with eunatraemic, eukalaemic hypoadrenocorticism, immune‐mediated anaemia and immune‐mediated thrombocytopenia, possibly representing an example of multiple autoimmune syndrome type 3. All abnormalities resolved and the patient was alive nearly 3 years later, maintained on physiological doses of prednisolone. This case serves as a reminder of the variable presentations of eunatraemic, eukalaemic hypoadrenocorticism and the potential for concurrent immune‐mediated disease.
Pregnancy and infertility in orthopedics: A review of the current state
Authors: Kermanshahi Nazanin , Hartman Hayden , Matzkin Elizabeth , Gianakos Arianna L. 
Published: April 2024

AbstractBackgroundOrthopedic surgery continues to have one of the lowest rates of female trainees among all medical specialties in the United States. Barriers to pursuing a surgical residency include the challenges of family planning and work–life balance during training.MethodsA systematic literature search of articles published between June 2012 and December 2022 in the MEDLINE, EMBASE, and Cochrane databases was performed in January 2023 according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analysis). Studies were included if they evaluated pregnancy and peripartum experience and/or outcomes amongst orthopedic surgeons or trainees.ResultsEighteen studies were included. Up to 67.3% of female orthopedic surgeons and trainees and 38.7% of their male counterparts delayed childbearing during residency. The most reported reasons for this delay included career choice as an orthopedic surgeon, residency training, and reputational concerns among faculty or co‐residents. Infertility ranged from 17.0% to 30.4% in female orthopedic surgeons and up to 31.2% suffered obstetric complications. Assisted Reproductive Technology (ART) resulted in 12.4%–56.3% of successful pregnancies. Maternity and paternity leaves ranged from 1 to 11 weeks for trainees with more negative attitudes associated with maternal leave.ConclusionsFemale orthopedic trainees and attending delay childbearing, experience higher rates of obstetric complications, and more stigma associated with pregnancy compared to their male colleagues. Program and institutional policies regarding maternity and paternity leave are variable across programs, and therefore, attention should be directed toward standardizing policies.
Nutritional Support
Authors: Baumgartner Annic , Schuetz Philipp 
Published: April 2024

AbstractPatients undergoing HCT, particularly allo-HCT, are at risk for malnutrition (Fuji et al., Food Nutr Sci 3:417–421, 2012).Based on “Supportive Care” in EBMT Handbook, 2009, by Tamás Masszi and Arno Mank.
Registries: A Bridge Between Donor and Recipient
Authors: Evseeva Irina , Foeken Lydia , Villa Juliana 
Published: April 2024

AbstractRegistries strive for a world where access to life-saving cellular therapies for all patients is assured and donors’ rights and safety are protected. Through the World Marrow Donor Association (WMDA), registries work together to ensure reliable provision of cells and are crucial partners for the clinical community in facilitating HCT and other cellular therapies.
Secondary Neoplasia (Other Than PTLPS)
Authors: Tichelli André , Rovó Alicia 
Published: April 2024

AbstractSecondary Neoplasia (SN) after HCT belong to the most feared long-term complications. They include any malignant disorder occurring after HCT. There are three types of SN: therapy-related myeloid neoplasms, occurring mainly after auto-HCT; donor-derived malignancies after allo-HCT; and second solid neoplasms after either auto- or allo-HCT. Many of these SN have a higher incidence compared to the general population. In this chapter, pathophysiology issues, risk factors, screening and management recommendations are discussed. Since SN can occur even decades after HCT, life-long surveillance is needed.
Endocrine Disorders, Fertility, and Sexual Health
Authors: Salooja Nina , Rovó Alicia , Dalle Jean-Hugues 
Published: April 2024

AbstractIncreasing numbers of HCT are being performed annually and outcomes continue to improve. As a result, survivorship issues are assuming increasing importance. Chemotherapy and radiotherapy remain cornerstones of HCT treatment, but, while lifesaving, they threaten endocrine function, fertility, and sexual function.
HCT in Elderly Patients
Authors: Duarte Rafael F. , Sánchez-Ortega Isabel 
Published: April 2024

AbstractThe hematological malignancies, which are the most common indications for auto- and allo-HCT (e.g., AML/MDS, NHL, MM, and others), are diagnosed at a median age greater than 65 years. Thus, if classical chronological age exclusion criteria were followed, a majority of patients with these malignancies would not be offered a HCT, despite it being their treatment of choice and in many cases their only curative option (Snowden et al. 2022). While elderly patients are more likely to face toxic effects from HCT, this risk must be considered and balanced against the poor outcome of transplant candidates with these malignancies who do not proceed to HCT (Dohner et al. 2022).
Myeloproliferative Neoplasms
Authors: Kröger Nicolaus , McLornan Donal P. , Chalandon Yves 
Published: April 2024

AbstractPolycythemia vera (PV) and essential thrombocythemia (ET) have a favorable outcome without need for allo-HCT unless the disease has progressed to post-ET/PV myelofibrosis or secondary AML (Lussana et al. 2014).
Fanconi Anemia and Other Hereditary Bone Marrow Failure Syndromes
Authors: Diaz-de-Heredia Cristina , Bierings Marc , Dalle Jean-Hugues , Fioredda Francesca , Strahm Brigitte 
Published: April 2024

AbstractInherited bone marrow failure syndromes (IBMFS) are a heterogeneous group of rare blood disorders due to hematopoiesis impairment, with different clinical presentations and pathogenic mechanisms. Some patients present with congenital malformations, may progress through clonal evolution (myelodisplasia, MDS and acute leukemia, AL) and are at risk for solid tumors at early ages. With the rapid evolution of diagnostic accuracy, the number of identified genetic defects rises annually. HCT is a curative treatment for these congenital disorders. However, it should be well understood that it will only correct the hematopoietic deficiency and will not cure the congenital malformations or reduce the risk of solid tumors. Moreover, HCT per se may increase this risk additionally. Consequently, the decision to transplant a patient should be taken by a multidisciplinary team. HCT must be performed at specialized centers owing to patient susceptibilities to toxicity and the need for specific management during and after the procedure. The general recommendations for management of IBMFS are included in the key points at the end of the chapter.
Systemic Light Chain Amyloidosis
Authors: Minnema Monique , Schönland Stefan 
Published: April 2024

AbstractSystemic light chain (AL) amyloidosis is a rare protein misfolding and deposition disorder. Clonal plasma cells or rarely B cells produce immunoglobulin light chains with the potential to misfold. Treatment is clone directed with the goal to achieve a complete or at least very good hematological remission. AutoHCT is an option in a selected group of patients. Results from cellular therapies are encouraging and will play an important role in the future.
Hydrodynamization in hybrid Bjorken flow attractors
Authors: Mitra Toshali , Mondkar Sukrut , Mukhopadhyay Ayan , Rebhan Anton , Soloviev Alexander 
Published: April 2024

Abstract
Hybrid fluid models, consisting of two sectors with more weakly and more strongly self-interacting degrees of freedom coupled consistently as in the semi-holographic framework, have been shown to exhibit an attractor surface for Bjorken flow. Retaining only the simple viscid fluid descriptions of both sectors, we find that, on the attractor surface, the hydrodynamization times of both subsectors decrease with increasing total energy density at the respective point of hydrodynamization following a conformal scaling, reach their minimum values, and subsequently rise rapidly. The minimum values are obtained when the respective energy densities are of the order of the inverse of the dimensionful inter-system coupling. Restricting to attractor curves which can be matched to glasma models at a time set by the saturation scale for both p-p and Pb-Pb collisions, we find that the more weakly coupled sector hydrodynamizes much later, and the strongly coupled sector hydrodynamizes earlier in p-p collisions, since the total energy densities at the respective hydrodynamization times of these sectors fall inside and outside of the conformal window. This holds true also for phenomenologically relevant solutions that are significantly away from the attractor surface at the time we match to glasma models.
Elliptic deformations of the AdS3 × S3 × T4 string
Authors: Hoare Ben , Retore Ana L. , Seibold Fiona K. 
Published: April 2024

Abstract
With the aim of investigating the existence of an integrable elliptic deformation of strings on AdS3 × S3 × T4, we compute the tree-level worldsheet S-matrix of the elliptically-deformed bosonic sigma model on AdS3 × S3 in uniform light-cone gauge. The resulting tree-level S-matrix is compatible with the integrability of the model and has interesting features, including a hidden U(1) symmetry not manifest in the Lagrangian. We find that it cannot be embedded in the known exact integrable R-matrices describing deformations of the undeformed AdS3 × S3 × T4 light-cone gauge S-matrix including fermions. Therefore, we construct embeddings of the deformed 6-d metric in type II supergravity with constant dilaton and homogeneous fluxes. The simplicity of these solutions suggests they are promising candidates to lead to an integrable string sigma model including fermions.
Function-guided differences of arcuate fascicle and inferior fronto-occipital fascicle tractography as diagnostic indicators for surgical risk stratification
Authors: Kram Leonie , Schroeder Axel , Meyer Bernhard , Krieg Sandro M. , Ille Sebastian 
Published: April 2024

Abstract
Background
Several patients with language-eloquent gliomas face language deterioration postoperatively. Persistent aphasia is frequently associated with damage to subcortical language pathways. Underlying mechanisms still need to be better understood, complicating preoperative risk assessment. This study compared qualitative and quantitative functionally relevant subcortical differences pre- and directly postoperatively in glioma patients with and without aphasia.

Methods
Language-relevant cortical sites were defined using navigated transcranial magnetic stimulation (nTMS) language mapping in 74 patients between 07/2016 and 07/2019. Post-hoc nTMS-based diffusion tensor imaging tractography was used to compare a tract’s pre- and postoperative visualization, volume and fractional anisotropy (FA), and the preoperative distance between tract and lesion and postoperative overlap with the resection cavity between the following groups: no aphasia (NoA), tumor- or previous resection induced aphasia persistent pre- and postoperatively (TIA_P), and surgery-induced transient or permanent aphasia (SIA_T or SIA_P).

Results
Patients with NoA, TIA_P, SIA_T, and SIA_P showed distinct fasciculus arcuatus (AF) and inferior-fronto-occipital fasciculus (IFOF) properties. The AF was more frequently reconstructable, and the FA of IFOF was higher in NoA than TIA_P cases (all p ≤ 0.03). Simultaneously, SIA_T cases showed higher IFOF fractional anisotropy than TIA_P cases (p < 0.001) and the most considerable AF volume loss overall. While not statistically significant, the four SIA_P cases showed complete loss of ventral language streams postoperatively, the highest resection-cavity-AF-overlap, and the shortest AF to tumor distance.

Conclusion
Functionally relevant qualitative and quantitative differences in AF and IFOF provide a pre- and postoperative pathophysiological and clinically relevant diagnostic indicator that supports surgical risk stratification.
Economic evaluation of intensive home treatment in comparison to care as usual alongside a randomised controlled trial
Authors: Barakat Ansam , Cornelis Jurgen E. , Dekker Jack J. M. , Lommerse Nick M. , Beekman Aartjan T. F. , Blankers Matthijs 
Published: April 2024

Abstract

Background
There is a dearth of research on the cost-effectiveness of intensive home treatment (IHT), an alternative to psychiatric hospitalisation for patients experiencing psychiatric crises. We therefore present a health economic evaluation alongside a pre-randomised controlled trial of IHT compared to care as usual (CAU).

Method
Patients were pre-randomised to IHT or CAU using a double-consent open-label Zelen design. For the cost-utility analysis, the EuroQol 5-dimensional instrument was used. The cost-effectiveness was assessed using the Brief Psychiatric Rating Scale (BPRS).

Results
Data of 198 patients showed that each additional QALY gained from offering IHT instead of CAU was on average associated with an extra cost of €48,003. There is a 38% likelihood that IHT will lead to more QALYs at lower costs compared to CAU. An improvement of one additional point on the BPRS by offering IHT instead of CAU was associated with an extra cost of €19,203. There is a 38% likelihood that IHT will lead to higher BPRS score improvements at lower costs. Based on the NICE willingness-to-pay threshold of £30,000 (€35,000) per QALY, IHT could potentially be considered cost-effective with a likelihood of 55–60% when viewed from a societal perspective, and > 75% from a health care perspective.

Conclusions
IHT appears slightly more attractive in terms of cost-utility and cost-effectiveness than CAU, although differences in both costs and effects are small especially when viewed from the societal costs perspective. From the health care sector costs perspective, IHT has a higher probability of being cost-effective compared to CAU.

Trials registration
Netherlands Trial Register: NTR6151.