bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluación del Complejo Convectivo a Mesoescala en el Perú, caso 14 de noviembre del 2003
Authors: Quispe G. Nelsón , García V. Jerónimo , Avalos R. Grinia 
Published: April 2024

El presente estudio tiene como objetivo describir y analizar la formación de un Complejo Convectivo de Mesoescala (CCM) en el Perú, usando las salidas del modelo regional Eta/SENAMHI. Para la formación de éste CCM se presentó una vaguada de onda corta del este en niveles medios y la Corriente en Chorro de bajos Niveles del Sur (SJ; siglas en ingles) que fue incentivado por la incursión de una Alta migratoria en continente generando vientos con escasa humedad desde las Pampas de Argentinas, desplazándose por las zonas bajas de Paraguay, selva de Bolivia e incursionando por la selva sur del Perú, que al encontrarse con las masas de aire cálido y húmedo procedentes de la Hoya Amazónica originó convergencia en bajos niveles dando lugar a la formación de nubosidad de gran desarrollo vertical en la selva Sur.
Propuesta de operación del sistema de riego regulado del proyecto Majes-Siguas
Authors: Huanca V. Leandro , Sánchez D. Miguel 
Published: April 2024

En el presente, ubicado en la Región Arequipa, es el Proyecto Especial de Irrigación más importante de la región y fue diseñado para una superficie agrícola de 57 000 ha. Es dividido en dos etapas: la Primera comprendió la construcción de la represa Condoroma y el sistema de conducción y construcción de canales de la Irrigación de las Pampas de Majes, teniendo como fin incorporar 23 000 ha. En la Segunda Etapa se ha proyectado la construcción de la represa Angostura y las centrales hidroeléctricas de Lluclla y Lluta, que permitirá la ampliación de la superficie agrícola hasta 57 000 ha. Dado el crecimiento poblacional, es necesario hacer continuamente la actualización de las ofertas y de las demandas de los recursos hídricos para diversos usos. Es así, que en el presente estudio, se determinaron las disponibilidades al 75% y 95% de persistencia en las estaciones de Condoroma, Tuti y Pitay, cuyos valores fueron 2.70, 3.79 y 2.37 m3/seg respectivamente, y, al 95% fueron de 1.56, 2.24 y 1.59 m3/seg. Respectivamente. En cuanto a las demandas, se calcularon utilizando los hidromódulos de 0.57, 0.60, 0.70 y 0.75 l/seg-ha., siendo estas de 11.930, 12.558, 14.651 y 15.697 m3/seg. respectivamente. Asimismo, se realizó la simulación de Operación del Sistema del Proyecto Majes-Siguas en su Primera Etapa con la ayuda del programa HEC-3, para un periodo de 42 años. Se han analizado diversas alternativas para cada uno de los escenarios definidos por cada hidromódulo de riego, a fin de determinar el valor de la demanda que condicione la operación del sistema de acuerdo a criterios preestablecidos. De la simulación llevada a cabo, se demuestra que los valores de las demandas de riego de las 20 930 ha para la Primera Etapa, pueden ser atendidas sin mayor problema con una persistencia en tiempo mayor al 78 %, no así al considerar los criterios de déficits del Water and Power Resources que da resultados conservadores, toda vez que de acuerdo a los hidromódulos de riego de 0.57, 0.60, 0.70 y 0.75 l/sha, se podrían irrigar 16,580; 15,750; 13,500 y 12,600 ha respectivamente en las Pampas de Majes.
Revolutionizing Wound Healing: Unleashing Nanostructured Lipid Carriers Embodied with Herbal Medicinal Plant
Authors: Jain Aditya , Yadav Shikha , Khan Javed 
Published: April 2024

Abstract:
Wound healing is crucial for maintaining skin integrity and preventing complications
from external threats. Various plants, such as Achillea millefolium, Aloe vera, Curcuma longa,
Calendula officinalis, Camellia sinensis, Azadirachta indica, and Plantago, have demonstrated
wound healing capabilities and have been used in herbal medicine for wound care. NLCs are
second-generation lipid nanoparticles, blending solid and liquid lipids to improve medication
loading and limit leakage. NLCs have been used in various applications, including cosmeceuticals,
chemotherapy, gene therapy, and brain targeting. Wound healing is divided into four stages:
hemostasis, inflammatory response, proliferation, and remodeling. Factors such as age, gender,
chronic disorders, and local agents like infections can affect recovery. These plants' antiinflammatory,
antioxidant, and antibacterial activities have demonstrated potential in wound
healing. Combining herbal medicinal plants and nanostructured lipid carriers (NLCs) can revolutionise
wound treatment and improve overall healthcare outcomes.
Evaluation and Characterization of Modified K114 Method to Localize
Plaques in Rodent and Plaques and Tangles in Human Brain Tissue
Authors: Padala Sanjana , Setti Sharay , Raymick James , Hanig Joseph , Sarkar Sumit 
Published: April 2024

Background:
A plethora of studies has shown the utility of several chemical dyes due
to their affinity to bind Aβ to enable visualization of plaques under light or fluorescence microscope,
and some of them showed affinity to bind neurofibrillary tangles (NFT) as well. However,
only a few of them have the propensity to bind both senile plaques (SP) and NFT simultaneously.

Objective:
In our current study, we aimed to modify the K114 dye and the staining procedure to
substantially improve the staining of amyloid plaques in both human and rodent brains and neurofibrillary
tangles in the human brain

Methods:
We modified the K114 solution and the staining procedure using Sudan Black as a modifier.
Additionally, to evaluate the target of the modified K114, we performed double labeling of
K114 and increased Aβ against three different epitopes. We used 5 different antibodies to detect
phosphorylated tau to understand the specific targets that modified K114 binds.

method:
We have modified the K114 solution and the staining procedure using Sudan Black as modifier. Additionally, to evaluate the target of the modified K114, we performed double labeling of K114, and Aβ raised against three different epitopes. We used 5 different antibodies to detect phosphorylated Tau to understand the potential binding targets.

Results:
Dual labeling using hyperphosphorylated antibodies against AT8, pTau, and TNT1 revealed
that more than 80% hyperphosphorylated tau colocalized with tangles that were positive
for modified K114, whereas more than 70% of the hyperphosphorylated tau colocalized with modified
K114. On the other hand, more than 80% of the plaques that were stained with Aβ MOAB-2
were colocalized with modified K114.

result:
We have found more than 80% hyperphosphorylated Tau against AT8, PTau and TNT1 colocalized with K114 labeled tangles, whereas more than 70% of the hyperphosphorylated Tau colocalized with modified K114. On the other hand, more than 80% of the plaques that were stained with amyloid beta MOAB-2 were colocalized with modified K114.

Conclusion:
Our modified method can label amyloid plaques within 5 min in the rat brain and
within 20 min in the human brain. Our results indicated that modified K114 could be used as a
valuable tool for detecting amyloid plaques and tangles with high contrast and resolution relative
to other conventional fluorescence markers.
Development and Characterization of Imatinib Mesylate Liposome: For
In-vitro Anti-cancer Activity
Authors: Patil Pravin , Choudhary Manju , Sankpal Poournima , Patil Sachinkumar , Gadad Anand 
Published: April 2024

Introduction:
According to our research, liposomes loaded with imatinib mesylate were
formulated using a rotary evaporator and the thin film hydration method. FTIR, DSC, and XRD studies
were carried out to ensure that the drug excipients in the final formulation were compatible.

Method:
The improved liposome batch (F7) was tested for particle size (353.9 nm), zeta potential (-
46.0 mV), drug release (92.8%), and entrapment efficiency (94.29%) after 72 hours. Studies using
TEM have shown that imatinib mesylate-loaded liposomes have a spherical form.

Result:
Finally, in-vitro anticancer activity was assessed through the MTT assay, which revealed an
IC50 value of 0.2959μg mL-1 for treating Human leukaemia monocytic cell lines.

Conclusion:
The process was refined based on data concerning the rotary evaporator speed, solvent
system ratio and volume, hydration media pH, manufacturing yield, entrapment efficiency, in-vitro
release, and improved in vitro anti-cancer activity.
The Implementation of Space Vector PWM in 36-Pulse D-STATCOM for Power Quality Improvement
Authors: Bandopadhyay Subhasis , Banerjee Atanu , Mondal Ashoke 
Published: April 2024

Introduction:
This paper addresses the ongoing challenge of harmonics reduction in
power systems, particularly focusing on Flexible AC Transmission Systems (FACTS) devices.
Instead of employing a conventional multilevel converter, an alternative configuration is proposed:
a 36-pulse gate turn-off thyristor-based converter (GTO-VSC). This converter comprises
three 12-pulse Voltage Source Converters (VSCs) as fundamental units, operating collectively on
the frequency mode of GTO switching control within a Distribution Static Synchronous Compensator
(D-STATCOM). The D-STATCOM dynamically compensates reactive power in the system.
The 36-pulse configuration results in AC output voltage waveforms containing harmonics such as
the 35th, 37th, 71st, 73rd, etc., leading to higher total harmonic distortion (THD) levels.

background:
Reduced number of switches in flexible AC transmission.

Method:
In response, the paper presents a new model featuring a 3-level, 36-pulse, 25kV,
±3MVAr STATCOM configured with 12-pulse GTO-VSCs. This model incorporates PWM gate
switching and employs a PI-control methodology to optimize harmonics in simulation, specifically
targeting harmonics at the 35th, 37th, 71st, 73rd, etc., orders using Sim Power Systems toolbox in
Math Works software.

Result:
The compensator's operational performance is controlled through switching angle optimization,
which minimizes harmonics, regulates voltage, and manages reactive power in the electrical
transmission system.

Conclusion:
The simulation results demonstrate that the proposed model is acceptable for enhancing
the flexibility and performance of the FACTS device in mitigating harmonics in power systems.
Prognostic influence of fibroblast growth factor 23 on the course of coronary heart disease in patients with chronic kidney disease
Authors: Samakaev A. S. , Glova S. E. , Khaisheva L. A. , Lapushkina M. A. , Shlyk S. V. 
Published: April 2024

Objective: to study the prognostic impact of the level of fibroblast growth factors 23 on coronary heart disease depending on the stage of chronic kidney disease. Materials and methods: the study included 108 patients with coronary heart disease (CHD), stable angina (stress), functional class 1–3, chronic kidney disease (CKD) C1–C4, average age was 67,62±12,51 years (55 men and 53 women). The level of fibroblast growth factor 23 was assessed using the Biomedica FGF 23 multimatrix enzyme-linked immunosorbent assay. After 12 months of follow-up, the presence of a cumulative endpoint including the occurrence of acute coronary syndrome, stroke, transient ischemic attack, heart failure and death. Differences in data and correlations between them were considered statistically significant at p<0.05. Results: the developed prognostic model to determine the likelihood of cardiovascular complications in patients with coronary artery disease and CKD found that the FGF 23 level is equal to 27.9 with a sensitivity of 62.7% and specificity of 62.5% to distinguish patients with ischemic heart disease and CKD in whom a cumulative endpoint will occur over 12 months of follow-up. Conclusions: to identify patients at high risk of cardiovascular complications in coronary artery disease and CKD, it is advisable to use determination of FGF 23 level.
Association of iron metabolism with erythrocyte parameters, myeloid and lymphoid cells in patients with sleep disorders
Authors: Ivaschenko A. A. , Kalinkin A. L. 
Published: April 2024

Objective: to identify the relationship between the main indicators of iron metabolism and erythrocyte parameters, myeloid and lymphoid cells in patients with sleep disorders in patients with sleep disorders (obstructive sleep apnea (OSA), chronic insomnia (CI), restless legs syndrome (RLS)). Materials and methods: 118 patients, 60 men (50.8%) and 58 women (49.2%), Me age — 47 years (Q1–Q3: 35–61), Me BMI — 25.81 kg/m2 (Q1–Q3: 22.72–29.40) with obstructive sleep apnea (OSA), chronic insomnia, restless legs syndrome in their various combinations. All patients underwent a polysomnographic study, blood cell count, biochemical parameters of iron metabolism were assessed. Results: when assessing the relationship between “Ferritin” and “Hemoglobin”, “Hematocrit (%)”, “Erythrocytes”, “Lymphocytes, abs.”, a moderate direct relationship was established (p<0.001; p<0.001; p=0.001; p< 0.013, respectively).When assessing the relationship between “RDW (%)”, “Neutrophils total, %”, “Neutrophils, abs.” and “%TS”, a moderate inverse relationship was established (p=0.026; p=0.028; p =0.01, respectively).When assessing the relationship between “RDW (%)”, “Neutrophils total, %” and “Serum iron”, a moderate inverse relationship was established (p = 0.003; p = 0.012, respectively). When assessing the relationship between “Lymphocytes, %” and “Serum iron”, a weak direct relationship was established (p = 0.049). Conclusions: in patients with sleep disorders, a statistically significant relationship was revealed between the main parameters of iron metabolism and indicators of “red” blood, the content of neutrophils and lymphocytes. It was shown for the first time that in patients with sleep disorders, changes in the content of neutrophils and lymphocytes may be associated not only with changes in sleep itself, but also with the state of iron metabolism. The complex relationships of iron metabolism, the function of erythrocytes, neutrophils and lymphocytes in patients with sleep disorders can affect the development of both infectious and non-infectious diseases through the mechanisms of maintaining chronic inflammation, hypoferemia, ferroptosis, netosis and other mechanisms.
ENERGY PROPERTIES OF SYMMETRIC DEFORMABLE SYSTEMS
Authors: Stupishin Leonid , Mondrus Vladimir 
Published: April 2024

Energy methods for calculating structures, which have become popular for a century, are based on the Lagrange principle and have the meaning of equality of work of external forces and internal forces. Having proved their effectiveness in the overwhelming majority of problems of structural mechanics, they became the dominant approach in formulating the problems of studying solid deformable systems and gave rise to the main methodology for solving problems. As a result, a situation has arisen that the internal potential energy of a deformed body remains insufficiently studied.
The paper develops an approach to the study of the symmetric structure at critical levels of strain energy. The criterion of critical levels of strain energy, based on the concepts of "self-stress" ("self-balance") of a deformable body. Limiting values of the structure strain energy may get by varying the reactions and deflections in the nodal points. The extreme values of forces and displacements of the rods are calculated in matrix form from the values of nodal reactions (displacements).
Methodology for studying the energy properties of a system is shown on the examples of the study of symmetric rod systems without involving the concept of external forces. The technique is based on matrix methods of structural mechanics and the mathematical apparatus of eigenvalue problems. The comparison of structural design and structural analysis solution of structural mechanics tasks by traditional methods and with the proposed methodology is carried out.
WAYS OF INCREASING OF LOADING CAPACITY OF THE REINFORCED CONCRETE SHALLOW SHELLS WITH A FLAT RECTANGULAR CONTOUR
Authors: Seyfullayev Khanlar , Jabrayilova Gulnara 
Published: April 2024

Shallow shells with variable curvature, prestressing contour and fixed above by horizontal reinforcing of two opposite contour elements are considered in the given article. These two offered ways practically produces non-moment state and increase loading capacity of the shallow shells several times. Method of definition of loading capacity of the shallow shells with a flat rectangular contour was worked out, and it's aim consists of that initial moment state before loss of loading capacity is described by nonlinear differential equations of the theory of the shallow shells. And then accentuating the main part of the solution of equations we receive the linear system of homogeneous differential equations with variable coefficients. The solution of the linearizated equations enables to define the forms of losing of loading capacity of shallow shells.
The Specifics of Self-Body Image Perception and Self-conception in Women with Different Body Mass Indexes
Authors: Yetumyan Luiza A. , Komerova Natalia E. 
Published: April 2024

Introduction. Currently, a relevant object of research is the identification of differences in women’s perception of their actual weight and subjective assessment of their body image and self-conception in relation to weight. Since the perception of body image is greatly influenced by fashion trends and beauty standards broadcast in society, women may exhibit different cognitive and behavioral patterns depending on their body mass index.Objective. To study the relationship between the features of perception of body image and self-esteem in women with different body mass indexesMaterials and methods. The following methods were used in the study: author’s questionnaire-questionnaire of Yetumyan L. A. and Komerova N. A. and Komerova N. E.; Thomas Cash’s Multimodal Body Self-Relationship Questionnaire (MBSRQ, Thomas F. Cash) adapted by Baranskaya L. T. and Tataurova S. T. and Tataurova S. С. The Mann-Whitney U statistic for two independent samples and the r-Spearman rank correlation coefficient were used for mathematical processing of the data.Results. The study included 137 women with different BMI values ranging from 17 to 72 years of age. The mean age of the respondents was 35 years. According to our questionnaire survey, more than 40 % of respondents had overweight or obesity of the 1st, 2nd or 3rd degree. The results are presented by five scales reflecting the following parameters of attitude to one’s own body: evaluation of appearance, appearance orientation, satisfaction with body parameters, concern about being overweight, self-assessment of weight. The results of comparative analysis in two groups have been described – women with low and normal BMI and women with excessive BMI.Discussion. Women in groups with different body mass index have differences in their orientation to appearance. Thus, the higher the weight of women with high BMI, the lower they evaluate the level of their attractiveness and the less effort they put into improving their appearance. They are also more indifferent to appearance. No such correlation was found in women with low and normal BMI. The high importance of appearance for women from both subgroups is directly correlated with a high level of concern about excess weight, which indicates an attitude to one’s own weight as one of the factors determining external attractiveness.
Identification of Predictors of a Meaningful Avoidance Strategy
Authors: Godunov Mikhail V. , Portnov Evgeny A. 
Published: April 2024

Introduction. In this section the authors present the relevance of the study of the semantic avoidance strategy which is maladaptive when coping with crisis and uncertain situations. We consider the assumption of the presence of predictors of a sense-forming avoidance strategy as a hypothesis that has significant correlations with the scales of the questionnaire for the study of avoidance.Objective. Presentation of the results of empirical identification of predictors of a meaningful avoidance strategy.Materials and methods. The author’s verbal questionnaire is presented and applied to study the avoidance strategy. It consists of 9 semantic scales of personality traits to study the specifics of avoidance. To identify its predictors, the battery of tests includes proven methods from the related fields of semantic regulation: the test of life orientations (D. A. Leontiev), the “New Questionnaire of tolerance-tolerance to uncertainty” (T. V. Kornilova).Results. The indicators for verifying the normality of the distribution of empirical indicators are presented as well as data from the correlation analysis of the battery of tests in the sample n = 282. Empirically established values of the Shapiro-Wilk coefficient have values higher than the required level of statistical significance ,05 for indicators of all scales of this battery of tests. Correlation analysis has established that there are three indicators of the scales of the tested tests, which have values of statistically significant empirical Pearson correlation coefficients with the scales of the author’s questionnaire.Discussion. Empirically calculated values of the Shapiro-Wilk criterion with respect was based on the satisfaction to a specified level of statistical significance ,05 it was found that all the studied indicators have a normal distribution character. This confirms the representative nature of the sample. According to the results of the correlation analysis conducted at the significance level ,05, the scales “process” and “locus of control – I” of the test “Life orientations” (D. A. Leontiev) were adopted as the main predictors of avoidance, and the scale “tolerance to uncertainty” according to the “New questionnaire of tolerance to uncertainty” was used as an auxiliary predictor (T. V. Kornilova). The stated hypothesis has been confirmed. Limitations of the study – testing did not affect respondents under the age of 18, as well as over the age of 47, and was conducted only for the types of profession “human – human” and “human – sign”. It is possible to conduct low-cost testing and build multifactorial personal avoidance profiles with the help of the identified predictors.