bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONFLUENT AND RETICULATED PAPILLOMATOSIS: CLINICAL, LIGHT AND ELECTRON MICROSCOPIC STUDIES
Authors: JIMBOW MIHOKO , TALPASH OREST , JIMBOW KOWICHI 
Published: May 2007

AbstractA case of a 17‐year‐old Japanese‐Canadian boy with a 2‐year history of skin lesions relevant to confluent and reticulated pa‐pillomatosis (CRP) is reported with electron microscopic findings. He had scattered skin lesions of brownish‐colored, rough‐surfaced, fine‐scaled patches and plaques distributed on the nape, shoulders, and both flanks, extending to the chest and back. Importantly, they showed reticular or confluent arrangement. There was no family history of the same skin lesions. The histology showed epidermal papillomatosis and mild acanthosis with a marked hyperkeratosis. Electron microscopically, the skin lesions consisted of the following abnormal findings: (1) a marked alteration of cornified cell structures showing snake coil‐like, or triangle‐like stacks, (2) a marked increase in the number of lamellar granules in the granular layer, (3). an increased number of melanosomes in the horny layers, and (4) no significant fine structural changes of epidermal melanocytes. This is the first electron microscopic report on CRP suggesting that the pathophysiology of this disease is related to abnormal keratinocyte differentiation.
RHABDOID TUMOR OF THE SKIN
Authors: SANGUEZA OMAR P. , MESHUL CHARLES K. , SANGUEZA PASTOR , MENDOZA RAUL 
Published: May 2007

AbstractA tumor in the skin of a 42‐year‐old man was analyzed by light and electron microscopic study and immunohistochemistry. The tumor cells were large and contained eosinophilic, periodic acid‐Schiff (PAS)‐positive inclusions in the cytoplasm. Immunohistochemically, the neoplasm was positive for intermediate filaments, cytokeratin, vimentin, desmin, and alpha‐1‐antichimotrypsin, and negative for S‐100 and leukocyte common antigen (LCA). Ultrastructurally, the cytoplasm and cellular processes of the cells were inundated with intermediate filaments, some of which were tightly bundled. Junctional complexes and secretory granules were absent. These features suggest a rhabdoid tumor: a malignant tumor of uncertain origin.
JOINT COMPLAINTS IN PSORIASIS PATIENTS
Authors: ZANOLLI MICHAEL D. , WIKLE JOHN S. 
Published: May 2007

AbstractFour hundred and fifty‐nine psoriasis patients seen at the Department of Dermatology, Bowman Gray School of Medicine of Wake Forest University, responded to a questionnaire concerning current or past joint complaints. Of these, 17% reported a previous diagnosis of psoriatic arthritis, and over 53% had a current or past history of arthralgias. Additional information on those patients reporting arthralgias focused on the cutaneous sites of involvement with psoriasis and which joints were most likely to be involved in patients with various types of arthritis. Previous treatments for skin involvement with psoriasis were more aggressive in those patients with a diagnosis of psoriatic arthritis. A significant proportion of patients presenting to dermatologists for treatment of psoriasis have joint complaints, and the percentage of patients with psoriatic arthritis is greater than generally appreciated by non‐dermatologists.
SYSTEMIC KETOCONAZOLE TREATMENT FORFUSARIUMLEG ULCERS
Authors: LANDAU MARINA , SREBRNIK AVIGDOR , WOLF RONNI , BASHI EDNA , BRENNER SARAH 
Published: May 2007

AbstractFusarium oxysporumwas isolated from a large foot ulcer in an otherwise healthy 69‐year‐old man. Although tissue invasion could not be proven histologically, systemic antifun‐gal treatment was administered with satisfactory response.Fusariumspecies are common soil‐inhabiting organisms and plant pathogens. In humans,Fusariumis considered an opportunistic agent in skin ulcers, interdigital spaces, and burned skin, but can also cause mycotic keratitis, onychomycosis, and rarely deep‐seated or disseminated infections, especially in an immunocompromised host. The distinction between skin infection and saprophytic growth, as well as optimal treatment regimens for the two types of infection, have not been clearly defined.We describe a case of leg ulcers caused byFusarium oxysporumin a 69‐year‐old man treated successfully with oral ketoconazole. “Silent” immunologic disturbances were found in this apparently healthy patient. The case illustrates a relatively benign infection caused byFusariumthat responded to systemic antifungal drug treatment.
DIFFUSE CUTANEOUS LEISHMANIASIS WITH ATYPICAL ASPECTS
Authors: BITTENCOURT ACHILÉA L. , HARRAL ALDINA , COSTA JACKSON M.L. , CRISTINA SALDANHA ANA , BADARO FERNANDO , BARRAL‐NETTO MANOEL , FREITAS LUIZ A.R. 
Published: May 2007

AbstractA 16‐year‐old man had long‐standing diffuse cutaneous leishmaniasis with the following characteristics: diffuse infiltrated lesions rich in amastigotes, absence of mucosal involvement, and lack of parasite‐specific cell‐mediated immune response. In situ identification of Leishmania mexicana amazonensis was achieved by the use of monoclonal antibodies. Clinically, as an atypical finding there was deep and extensive ulceration in the lower limbs. Histologically, an atypical characteristic was the presence of a high number of eos‐inophils in the infiltrate predominantly in the ulcerated lesion. Ultrastructurally, parasitized and lysed eosinophils with dispersion of their granules were seen in the vicinity of parasitized or lysed macrophages.
PYODERMA GANGRENOSUM TREATED WITH HYPERBARIC OXYGEN THERAPY
Authors: WASSERTEIL VIVIAN , BRUCE SUZANNE , SESSOMS SANDRA L. , GUNTUPALLI KALPALATHA K. 
Published: May 2007

AbstractThe management of pyoderma gangrenosum often requires systemic drug therapy, such as corticosteroids, sulfones, or immunosuppressants, either alone or in combination. Inconsistent response to therapy is a source of frustration to both patient and physician. Several reports in the literature document the successful treatment of pyoderma gangrenosum with hyperbaric oxygen therapy. In our patient, a woman with severe rheumatoid arthritis and diabetes mellitus, hyperbaric oxygen therapy not only promoted healing of pyoderma gangrenosum but permitted reduction of systemic corticosteroids.
EXPRESSION OF T6 ANTIGEN ON KERATINOCYTES IN ALOPECIA AREATA
Authors: LOTTI TORELLO , KNOEPFEL BIRGIT , ZANGHERI MARCELLO , PANCONESI EMILIANO 
Published: May 2007

AbstractThe expression of T6 antigen within hair follicles in alopecia areata was studied using the APAAP technique (alkaline phosphatase monoclonal anti‐alkaline phosphatase method). Scalp biopsies were taken from 15 subjects with alopecia areata, nine in an active stage and 6 in a stationary stage of the disease. Six‐micrometer‐thick frozen sections were stained with OKT6 antiserum. OKT6 are monoclonal antibodies raised against human thymocytes; they cross‐react with epidermal Langerhans ceils and are a highly specific marker. Nine of the specimens displayed T6 staining on keratinocytes in the bulb matrix, and all nine were from the subjects presenting the active stage of disease. The specimens from the other six biopsies, from subjects in a stationary stage, did not show T6 staining of bulbar keratinocytes. Moreover, in four of the active‐stage cases we found T6 staining also on epidermal keratinocytes.
ERYTHROMYCIN VERSUS CEEADROXIL IN THE TREATMENT OF SKIN INFECTIONS
Authors: HESKEL NEIL S. , SIEPMAN NANCY C. , PICHOTTA PHILIP J. , GREEN ELIZABETH M. , STOLL RALPH W. 
Published: May 2007

AbstractErythromycin is often overlooked for the treatment of skin and skin structure infections. We evaluated the efficacy and safety of erythromycin particles in tablets and of cefadroxil in 164 patients with skin infections; both treatments were given as 500 mg twice daily. One hundred percent of erythromycin and 96% of cefadroxil patients were clinically cured or improved, and 98% of susceptible pathogens were eradicated in both groups. Only three erythromycin patients and one cefadroxil patient left the study early because of GI‐related adverse events. Erythromycin, therefore, was as effective and safe as cefadroxil in the treatment of mild‐to‐moderate skin infections.
ELECTROTRICHOGENESIS: FURTHER EVIDENCE OF EFFICACY AND SAFETY ON EXTENDED USE
Authors: MADDIN W. STUART , AMARA INGRID , SOLLECITO WILLIAM A. 
Published: May 2007

AbstractThese data represent a subset of data from the original 36‐week study conducted by Maddin et al.,1 which was in itself a preliminary study of a pulsed electrical stimulation device in male subjects alone. The extension phase of this study, which is summarized here, was undertaken to gather data on longer‐term efficacy and safety and to study clinical effects in control subjects who were then switched to active treatment. Thirteen subjects had active treatment for 70 weeks, and 14 subjects were included in the crossover group, which had sham treatment for 36 weeks followed by active treatment for 30 additional weeks. On average, terminal hair counts increased from 82 to 276 in the active treatment group. Among those in the crossover group, a mild increase, from 124 to 160, was observed during the sham treatment period and a more notable increase, from 160 to 249, occurred during the subsequent active treatment period. The results presented here provide evidence of the efficacy and safety of this device during extended use; however, the generalizability of these findings is limited by the small subset of subjects for whom complete data are available.
CUTIS MARMORATA TELANGIECTATICA CONGENITA
Authors: KENNEDY CORNELIS , ORANJE ARNOLD P. , KEIZER KOOS , VAN DEN HEUVEL MARY M. , CATSMAN‐BERREVOETS CORIENE E. 
Published: May 2007

AbstractThe authors describe ten cases of cutis marmorata telangiectatica congenita (CMTC). All of these cases were sporadic. The incidence of associated anomalies was relatively low, and three patients had skin manifestations (cutaneous atrophy and nevus telangiectaticus). In two patients, the right leg was shorter and thinner. Another two showed neurologic symptoms without lasting neurologic damage. New associated anomalies, such as tendinitis stenosans and bowing of the lower legs, did not provide additional information regarding the cause of CMTC. The authors suggest that Happle's lethal gene hypothesis for Klippel‐Trenaunay and Sturge‐Weber syndromes also could be applied to CMTC.
OCCUPATIONAL OR EXTRINSIC STIMULATION FACTORS AND INITIAL SIGNS OF PROGRESSIVE SYSTEMIC SCLEROSIS
Authors: MAEDA MANABU , MORI SHUNJI 
Published: May 2007

AbstractForty‐eight patients with progressive systemic sclerosis (PSS) (man‐woman ratio, 7:41) were studied, and detailed questionnaires were used to clarify the relationship between occupational stresses and the initial signs of PSS. All of the patients were right‐handed. Raynaud sign was seen in 37 of the 48 patients (77.1%) as the predominant initial sign of PSS, and it first was noticed on the right index and middle fingers. Three sets of extrinsic aggravating factors, vibration stress, fine hand work with mental stress, and exposure to cold, were believed to be related closely to the development of the initial signs because the initial signs appeared after long‐term exposure to the extrinsic factors.
ULTRASTRUCTURAL CHANGES IN ACQUIRED PERFORATING DERMATOSIS
Authors: PATTERSON JAMES W. , BROWN PATRICIA C. 
Published: May 2007

AbstractWe performed ultrastructural studies of skin lesions in seven adults with acquired perforating dermatosis. Three of the patients had diabetes mellitus and two were undergoing hemodialysis. Lesions in an early stage showed exocytosis of inflammatory cells and alteration of elastic fibers. Lesions in an intermediate stage featured discontinuities of the basement membrane and aggregates of electron‐dense material lateral to the perforated focus, together with dermal edema, scattered macrophages, and densely aggregated collagen fibers that focally filled the papillary dermis. Later‐stage lesions showed fibroblasts in the dermis and degenerated elastic fibers within transepidermal channels. In most cases there was a single large epidermal channel lined by flattened epithelial cells, and containing a variety of cellular and extracellular materials. Small “secondary” channels without abnormal keratinization were also observed within the epidermis. The findings suggest that altered keratinization is limited to the immediate vicinity of well‐formed transepidermal channels, and that exocytosis of inflammatory cells and alterations of elastica are early and possibly key changes in lesion development. The unexpected discovery of hair fragments in one case suggests that curled hairs may play a role in the pathogenesis of some cases of acquired perforating dermatosis.
SUBSTANCE P PROVOKES CUTANEOUS ERYTHEMA AND EDEMA THROUGH A HISTAMINE‐INDEPENDENT PATHWAY
Authors: CAPPUGI PIETRO , TSAMPAU DIONIGI , LOTTI TORELLO 
Published: May 2007

AbstractSubstance P is a neuropeptide (contained in/and released from the Aδ and C nerve fibers of the skin), which provokes erythema, edema, and pruritus after intradermal injection. Local pretreatment with capsaicin produces decreased substance P‐dependent erythema, with edema similar to that observed before pretreatment with capsaicin. We injected histamine and, in a parallel experiment, substance P in five volunteers before and after local treatment with capsaicin, with 48/80, after 5 days of hydroxyzine. The injection of sp provoked erythema centered by a wheal. After treatment with 48/80, sp provoked increased erythema and a wheal. After hydroxyzine treatment, the injection of histamine produced no erythema or edema in four of the five subjects, while sp provoked erythema in all five subjects and edema similar to that observed before treatment with hydroxyzine. These data support the hypothesis that substance P provokes erythema and edema both with histamine‐dependent and histamine‐independent pathways.
VITILIGO IN CHILDREN
Authors: JAISANKAR TELANSERI JAYAKAR , BARUAH MANIK CHANDRA , GARG BHAGAT RAM. 
Published: May 2007

AbstractIn our study the relative incidence of vitiligo among new patients was 2.6%. Twenty percent were children and 74% were adults. Of the 90 children, 38.9% were boys, and 61.1% were girls. This sex difference was statistically highly significant. The adult sex‐ratio was not statistically significant. The relative incidence of the clinical subtypes in children and adults was compared, and the difference was found to be statistically highly significant only in the case of vitiligo vulgaris and segmental vitiligo. On the basis of the difference in the sex‐ratio and in the relative incidence of the subtypes of vitiligo vulgaris and segmental vitiligo, we feel that childhood vitiligo is a distinct subtype of vitiligo.
MULTIPLE BASAL CELL CARCINOMA IN TROPICAL AUSTRALIA
Authors: CZARNECKI D. , COLLINS N. , CHOW P. , NICHOLSON I. , TAIT B. 
Published: May 2007

AbstractNo association between HLA DP1 and the development of multiple basal cell carcinomas (BCC) was found among patients who had lived at least two‐thirds of their lives in the tropics. The percentage of patients with multiple BCCS increased with age; this was different from what has been found in people living in the temperate zone of Australia.
NEW APPROACHES TO ASSESS TOPICAL CORTICOSTEROID BIOEQUIVALENCE: PHARMACOKINETIC EVALUATION
Authors: PERSHING LYNN K. 
Published: May 2007

AbstractAn ideal method for measuring the bioavailability of topical corticosteroids should be simple, accurate, and adaptable to a variety of settings and should not require extensive special training to perform. Drug uptake into the stratum corneum, measured by tapestripping, is correlated with the pharmacodynamic response of skin blanching, observed in the vasoconstrictor assay. Differences in stratum corneum drug uptake can be objectively quantitated as a function of time, occlusion, dose applied, and vehicle. Tapestripping measurements are reproducible within individual subjects, but large interindividual variabilities may exist. The chromameter, a new technology, objectively quantitates color numerically and can be used to measure skin blanching as part of the pharmacodynamic response to topical corticosteroids. The chromameter offers an easy, objective method with which to quantitate the pharmacodynamic response of topical corticosteroids. Both methods allow a more mechanistic approach than currently used methods to investigate topical drug pharmacokinetics and pharmacodynamics.
HEMOSTASIS AND PLATELET AGGREGATION IN I'URPURIC PIGMENTED ANGIODERMATITIS ERUPTIONS
Authors: VIGNALF RAUL , RIZZO MARGARITA GARCIA 
Published: May 2007

AbstractTen patients with chronic purpuric and pigmented angiodermatitis in the extremities and two patients with acute and disseminated eczematoid‐like purpura angiodermatitis were studied with current hemostasis parameters: (I) platelet aggregation, (2) platelet circulating aggregates, (3) clotting factor measurements and high molecular weight kininogen (HMWK) in their coagulation fraction. The results showed: (I) reactional thrombocytosis with morphologic changes; (2) increased levels of platelet circulating aggregates; (3) increased response of platelet aggregation to different agonists, especially at very low doses, and also when we used washed platelets resuspended in normal plasma; (4) delayed activation of the contact system; (5) decrease of the activity of the fibrinolysis activators; and (6) diminished function activity of the HMWK coagulation fraction. As a physiopathogenic hypothesis In these patients, there is a cutaneous pathology that could be entailed to these hematologic alterations of the platelet‐HMWK‐endothelial cellskinins‐coagulation‐fibrinolysis system.
ITRACONAZOLE IN THE TREAMENT OF CHROMOBLASTOMYCOSIS DUE TO FONSECAEA PEDROSOI
Authors: QUEIROZ‐TELLES FLÁVIO , PURIM KHATIA S. , FILLUS JOSE N. , BORDIGNON GISELE F. , LAMEIRA ROSÁNGELA P. , VAN CUTSEM JAN , CAUWENBERGH GERT 
Published: May 2007

AbstractThe efficacy and tolerability of itraconazole in chromoblastomycosis due to Fonsecaea pedrosoi were evaluated in a non‐comparative open clinical trial in 19 Brazilian patients with histopathologically and mycologically proven active chromoblastomycosis. Patients were classified in terms of severity and received itraconazole at the dosage of 200 to 400 mg per day until previously described criteria of cure have been reached. Clinical, mycologic, histopathologic, and laboratory evaluations were performed before, during, and after therapy. The plasma levels of itraconazole and the in vitro susceptibility of the isolates were determined in 15 cases. Clinical and biologic cure were achieved by eight patients (42%) having mild to moderate disease, after a mean duration of therapy of 7.2 months (3.2–29.6 months). Sterile scarred lesions were observed in a post‐therapy follow‐up lasting on average 9.6 months that was carried out in this subgroup. Clinical cure alone occurred after a mean period of 25.1 months of treatment (16–30.5 months) in seven patients (36%) with moderate to severe disease. Finally, clinical improvement was obtained in four patients (21%) with severe lesions after a mean treatment time of 17.6 months (10.7–22.5 months). All patients responded favorably to itraconazole therapy. No significant side effects nor biochemical alteration during this trial were important enough to interrupt the treatment. Our results support those of previous trials, suggesting that itraconazole is an effective compound against chromoblastomycosis due to Fonsecaea pedrosoi.
URINARY RETENTION ASSOCIATED WITH HERPES ZOSTER INFECTION
Authors: COHEN LISA M. , FOWLER JOSEPH F. , OWEN LAFAYETTE G. , CALLEN JEFFREY P. 
Published: May 2007

Abstract Background. Herpes zoster infection particularly involving the sacral dermatomes has been associated with bladder and bowel dysfunction, most commonly urinary retention. Case Reports. We report two patients who developed acute urinary retention, one of whom also had constipation, within days of herpes zoster skin lesions of the S2‐S4 dermatomes. Conclusions. Herpes zoster is a reversible cause of neuro‐genic bladder and bowel dysfunction and should be considered in a patient that presents with acute urinary retention and/or constipation. Sensory abnormalities and flaccid detrusor paralysis are most likely involved in the pathogenesis.
CLINICAL AND LABORATORY EVALUATION OF AIDS TRICHOPATHY
Authors: SADICK NEIL S. 
Published: May 2007

Abstract Background. The present study reports the incidence of trichocutaneous disorders studied in 500 patients infected with HIV I in a large university‐based setting. Correlation of these findings with immunologic function at the time of diagnosis is presented. Unusual presentations and therapeutic interventions are discussed. Prognosis as related to various trichocutaneous disorders is elaborated. Methods. All patients in this study were hivi positive by Western blot assay. T‐cell subsets were evaluated by monoclonal antibodies against T‐cell surface markers. Hair disorders were analyzed by means of light hair pull test, hair mount, polarizing microscopy, trichogram, scalp biophsy, and cultures for bacteria, fungi, and mycobacteria as indicated. Trichologic manifestations were classified based upon immunologic correlation of absolute level of helper T cells/mm3. Results. The majority of hair disorders in the study population occurred with helper T cell numbers of less than 150/mm3. Papulosquamous problems including seborrheic dermatitis and psoriasis were most commonly noted followed by disorders of cell growth cycle regulation and trichokeratinization, i.e., telogen effluvium and loose anagen syndrome. Conclusions. Multiple trichocutaneous disorders occur in the setting of retroviral infection. Most of these disorders occur in the setting of progressive immunoincompetence. The awareness of the disorders described here will aid the clinician in both the recognition and management of pilar aberrations in the appropriate clinical setting.
MALIGNANT MELANOMA IN CHILDREN
Authors: CHUN KEVIN , VÁZQUEZ MIGUEL , SANCHEZ JORGE L. 
Published: May 2007

Abstract Background. While significant risk factors for malignant melanoma may initially develop or are first seen in childhood, the actual occurrence of this neoplasm in prepubertal children is uncommon. Methods. A retrospective study of malignant melanoma in Puerto Ricans up to 16 years of age occurring from 1973 to 1990 was carried out by identifying those cases in the Puerto Rico Cancer Registry. Results. A total of seven cases were found consisting of three boys and four girls with ages ranging from 22 months to 16 years and comprising 0.94% of the total melanomas. In three of the seven cases, there was a history of a previously existent small congenital melanocytic nevus on the area. Three cases were Clark's level I, two level II, and in two cases with proved metastatic disease, Clark's level of invasion were not reported. Those cases with Clark's level I and II had a 100% 5‐year survival. Conclusions. Although rare, malignant melanoma in children can be as aggressive as in adults. Among the known factors predisposing to malignant melanoma, three out of seven cases developed within a small congenital nevus, two of which occurred during the first decade of life. Due to the rarity of this event in our population, it appears unreasonable to excise all small congenital nevi during the first decade of life. Even for those who advocate excision of all small congenital nevi, the evidence at present suggests that such small nevi very rarely undergo malignant change before puberty and therefore a policy of observation in childhood and offering excision around the time of puberty is perfectly logical.