bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adapting to discontinuous technological change from the perspective of knowledge management: a case study from the lighting industry in Lin’an, China
Authors: Li Zhengwei , Li Wenxin , Carusone Rosalinda , Profita Sofia 
Published: March 2024

Purpose
This study aims to answer the question of how incumbent firms cultivate dynamic capabilities through knowledge management so that they can efficiently adapt to the changing external environment.

Design/methodology/approach
This study adopts a case study approach and collects data through interviews and secondary public information on the lighting industry and two lighting firms in Lin'an, China. It qualitatively examines the challenges and strategic recommendations for incumbent firms in the context of discontinuous technological change from a knowledge management perspective.

Findings
Incumbent firms often face a variety of challenges when responding to discontinuous technological change. These challenges include identifying opportunities, overcoming path dependence and dealing with employee resistance to change. To overcome these difficulties, three strategies have been proposed to enhance the dynamic capabilities of incumbent firms through knowledge management: cross-border search helps firms improve their knowledge acquisition capabilities and better understand their environment to identify opportunities; building strategic leadership overcomes path dependence and improves knowledge integration capabilities; organizational learning deepens employees’ understanding of change and enhances organizational knowledge application capabilities.

Research limitations/implications
Previous research attributes a firm's ability to cope with discontinuous technological change solely to its general resources, which weakens the importance of knowledge management in this context. This study emphasizes the importance of knowledge as a crucial strategic resource in developing the essential dynamic capabilities for incumbent firms to cope with discontinuous technological change.

Practical implications
This study provides an in-depth analysis of incumbent firms' coping strategies in the new context of discontinuous technological change and further promotes cross-disciplinary research.

Originality/value
This study provides an in-depth analysis of coping strategies in the new context of discontinuous technological change, furthermore theoretically advancing the interdisciplinary research of firm transformation and knowledge management. Meanwhile, it is crucial to identify the preconditions for cultivating dynamic capabilities, especially from a knowledge-based view, which enhances the depth of knowledge management research.
The efficacy of psychoeducation to improve personal skills and well-being among health-care professionals returning to clinical practice: a pilot pre-post study
Authors: Szekely Raul , Mazreku Syrgena , Bignell Anita , Fadel Camilla , Iannelli Hannah , Vega Marta Ortega , O'Sullivan Owen P. , Tiley Claire , Attoe Chris 
Published: March 2024

Purpose
Many health-care professionals leave clinical practice temporarily or permanently. Interventions designed to facilitate the return of health-care professionals fail to consider returners’ psychosocial needs despite their importance for patient care. This study aims to evaluate the efficacy of a psychoeducational intervention in improving personal skills and well-being among UK-based health-care professionals returning to clinical practice.

Design/methodology/approach
In total, 20 health-care professionals took part in the one-day intervention and completed measures of demographics, self-efficacy, positive attitudes towards work and perceived job resources before and after the intervention. A baseline comparison group of 18 health-care professionals was also recruited.

Findings
Significant associations were detected between return-to-work stage and study group. Following the intervention, participants reported improvements in self-efficacy and, generally, perceived more job resources, whereas positive attitudes towards work decreased. While none of these changes were significant, the intervention was deemed acceptable by participants. This study provides modest but promising evidence for the role of psychoeducation as a tool in supporting the psychosocial needs of returning health-care professionals.

Research limitations/implications
Additional research is needed to clarify the reliability of intervention effects, its effectiveness compared to alternative interventions, and the impact across different subgroups of returning health-care professionals.

Practical implications
Return-to-practice interventions should address the psychosocial needs of health-care professionals in terms of their personal skills and well-being. Psychoeducation can increase self-efficacy and perceptions of job resources among returning health-care professionals.

Originality/value
This study sheds light on a relatively understudied, but fundamental area – the psychosocial challenges of health-care professionals returning to clinical practice – and further justifies the need for tailored interventions.
The information needs of users in the metaverse communities: a grounded theory study
Authors: Guo Yajun , Ma Huifang , Zhou Jiahua , Chen Yanchen , Yuan Yiming 
Published: March 2024

PurposeThis article aims to understand users' information needs in the metaverse communities and to analyze the similarities and differences between their information needs and those of users in Internet communities.Design/methodology/approachThis study conducted semi-structured interviews with users in the metaverse communities to gather raw data. Grounded theory research methods were employed to code and analyze the collected interview data, resulting in the extraction of 40 initial concepts, 15 subcategories and 5 main categories. Based on Maslow’s hierarchy of needs theory, this paper constructs the hierarchical model of users' information needs in the metaverse communities. It compares the differences between users' information needs in the metaverse and Internet fields.FindingsThe user’s information needs in the metaverse communities are divided into two types: deficiency needs and growth needs. Deficiency needs have two levels. The first level is the demand for basic information resources. The second level is the users demand for information assistance. Growth needs have three levels. The first level is the need for information interactions. The second level is the need for community rules. The ownership information in the community rules can provide proof of user status, assets and so on. The third level is the need for users to contribute and share their own created information content.Originality/valueThis article presents the latest research data from in-depth interviews with users in the metaverse communities. It aims to help builders and managers of metaverse communities understand users' information needs and improve the design of virtual communities.
Comparison of elastic anisotropy in the Middle and Upper Wolfcamp Shale, Midland Basin
Authors: Sayers Colin M. , Dasgupta Sagnik 
Published: March 2024

AbstractOrganic‐rich shales contain large amounts of oil and gas and are anisotropic because of fine‐scale layering and the partial alignment of organic matter and anisotropic clay minerals with the bedding. An example is the Wolfcamp Shale in the Permian Basin. Elastic anisotropy needs to be accounted for in the characterization of such formations using seismic data and plays a role in hydraulic fracturing and in the evaluation of stress changes and geomechanical effects resulting from production. Using extensive well log data acquired in the Midland Basin, the eastern sub‐basin of the Permian Basin, we estimate and compare the elastic anisotropy in the Middle and Upper Wolfcamp Shale by combining data from a vertical pilot well with two lateral wells, one (6SM) drilled in the Middle Wolfcamp and one (6SU) drilled in the Upper Wolfcamp. The data used were acquired at the Hydraulic Fracture Test Site 1, located in the eastern part of the Midland Basin. Thomsen's anisotropy parameter calculated from the fast and slow shear sonic is higher on average for the 6SM lateral than for 6SU, consistent with there being less carbonate content in 6SM than in 6SU. However, the anisotropy parameter in some regions with higher carbonate content in well 6SU is higher than in well 6SM. This may indicate the influence of natural fractures. The primary set of steeply dipping fractures observed in the lateral wells at Hydraulic Fracture Test Site 1 acts to increase if the ratio of the normal‐to‐shear fracture compliance is less than about 0.5. Sub‐horizontal fractures may also increase and could affect the vertical extent of hydraulic fractures. Relations between elastic moduli C33 and C55 in the Upper and Lower Wolfcamp in a vertical pilot well allow C33 to be predicted in a lateral well using measurements of C55 in that well. Comparison of Thomsen's anisotropy parameters and , with calculated from the measured values of C55 and C66 and calculated from the measured values of C11 and predicted values of C33, show that is mostly greater than .
Evolution of the ecological niche behind the largest disjunct freshwater fish distribution in the world
Authors: Ramírez‐Álvarez Rodrigo , Peterson Townsend A. , Contreras Sergio , Górski Konrad 
Published: March 2024

Abstract

Ecological processes that are behind distributions of species that inhabit isolated localities, complex disjunct distributions, remain poorly understood. Traditionally, vicariance and dispersion have been proposed as explanatory mechanisms that drive such distributions. However, to date, our understanding of the ecological processes driving evolution of ecological niches associated with disjunct distributions remains rudimentary.

Here, we propose a framework to deconstruct drivers of such distribution using World's most widespread freshwater fish Galaxias maculatus as a model and integrating marine and freshwater environments where its life cycle may occur. Specifically, we assessed ecological and historical factors (Gondwanan vicariance, marine dispersion) and potential dispersion (niche‐tracking) that explain its distribution in the Southern Hemisphere.

Estimated distribution was consistent with previously reported distribution and mainly driven by temperature and topography in freshwater environments and by primary productivity and nitrate in marine environments. Niche dynamics of G. maculatus provided evidence of synergy between vicariance and marine dispersion as explanatory mechanisms of its disjunct distribution, suggesting that its ecological niche was conserved since approximately 30 Ma ago.

This integrated assessment of ecological niche in marine and freshwater environments serves as a generic framework that may be applied to understand processes underpinning complex distributions of diadromous species.
Relationships between rhizosphere microbial communities, soil abiotic properties and root trait variation within a pine species
Authors: Lin Dunmei , Shen Rong , Lin Jiani , Zhu Guangyu , Yang Yongchuan , Fanin Nicolas 
Published: March 2024

Abstract

Rhizosphere microbes play important roles in plant performance and ecosystem functioning. It is becoming increasingly clear that rhizosphere communities vary with soil properties and variation in root traits among plant species. However, less is known about whether and how variation in root traits within plant species influences the rhizosphere microbial communities.

We evaluated the intraspecific root traits variation and explored their associations with bacterial and fungal communities in rhizosphere by focusing on an ectomycorrhizal tree species, that is Pinus massoniana, in 22 sites in subtropical China.

The first dimension of the principal component analysis on root traits revealed evidence for the ‘conservation’ gradient of the root economics space. Overall, root traits explained more variation in fungal communities than in bacterial communities in the rhizosphere. Functional composition of rhizosphere microbial communities changed significantly along the ‘conservation’ gradient, with fast‐growing copiotrophic bacteria and symbiotic ectomycorrhizal fungi were significantly enriched on the ‘acquisition’ side, while slow‐growing oligotrophic bacteria were significantly enriched on the ‘conservation’ side of the gradient.

Synthesis: Our study demonstrates that intraspecific variation in plant roots significantly influence rhizosphere microbial communities, which in turn can influence plant nutrition and therefore plant performance within the community.
Prevalence and prenatal diagnosis of congenital eye anomalies: A population‐based study
Authors: Maillet Corentin , Guilbaud Lucie , Monier Isabelle , Khoshnood Babak , Quoc Emmanuel Bui , Dugas Anais , Lelong Nathalie , Jouannic Jean‐Marie 
Published: March 2024

AbstractObjectiveTo estimate the prevalence and trend of congenital eye anomalies (CEAs) and the rate of prenatal diagnosis over a 10‐year period.DesignRetrospective population‐based registry study.SettingAll maternity units in Paris, France, from 2010 to 2020.PopulationA cohort of 115 cases of CEA detected among all live births or stillbirths, after 22 weeks of gestation, and terminations of pregnancy.MethodsThe total prevalence of CEAs and prevalence of each specific CEA were calculated using 95% Poisson exact confidence intervals.Main outcome measuresThe total prevalence of CEAs and the proportion of prenatal diagnosis of CEAs, and their evolution.ResultsThe prevalence of CEAs was 4.1 (95% CI 3.4–5.0) cases, ranging between 3.1 and 5.7 cases, per 10 000 births. CEAs were prenatally diagnosed in 23.5% of cases. CEAs were bilateral in 51 cases (44.3%), unilateral in 43 cases (37.4%) and missing or unknown in 21 cases (18.3%). Of those with CEAs, 20.9% had genetic anomalies and 53.0% had at least one other extraocular anomaly. When detected prenatally, CEAs were bilateral in 15 cases (55.6%), unilateral in eight cases (29.6%) and missing in the four remaining cases. The prenatal diagnosis rate of CEAs associated with genetic anomalies, CEA cases with at least one other malformation and isolated CEA cases were 29.2%, 26.2% and 13.3%, respectively.ConclusionsIn total, 115 cases of CEAs were observed during the study period, representing a total prevalence of 4.1 cases per 10 000 births. The overall prenatal detection rate of CEAs in our population was 23.5%, which dropped to 13.3% for isolated cases of CEAs.
Has the rescheduling of modified‐release paracetamol in Australia affected the frequency of overdoses?
Authors: Ryan Michaela J , Graudins Andis , O'Shea Nicole , Noghrehchi Firouzeh , Wong Anselm 
Published: March 2024

ObjectivesIn June 2020, modified‐release paracetamol (paracetamol‐MR) preparations were up‐scheduled from schedule‐2 (available in pharmacy) to schedule‐3 (available by request to a pharmacist only). The present study aims to ascertain whether up‐scheduling affected the frequency of paracetamol‐MR overdoses.MethodsThis is a retrospective cohort study of two data sets from 1 June 2017 to 31 May 2022. Monash Health data were extracted using the diagnosis of paracetamol overdose coding and electronic medical records data. Calls regarding paracetamol‐MR overdoses to Victorian Poisons Information Centre (VPIC) were extracted from the Poisons centre call database. We used a quasi‐experimental research design with interrupted time series analysis to evaluate the immediate impact and change in trend of poisoning‐related calls and ED presentations before and after June 2020. The change in proportion of paracetamol‐MR cases in both databases was analysed using the Χ2 test.ResultsThe proportion of paracetamol‐MR cases in both data sets did not change. From Monash Health, there was no level change in monthly paracetamol‐MR overdose‐related presentations following re‐scheduling (rate ratio [RR] = 1.08, 95% confidence interval [CI] = 0.57–2.01). There was no change in monthly paracetamol‐MR overdose‐related calls to VPIC following re‐scheduling (RR = 1.05, 95% CI = 0.96–1.14).ConclusionThe proportion of paracetamol‐MR overdoses did not decrease after the up‐scheduling to S3. Similarly, the frequency of overdoses by month remained similar. Further limitations on access to paracetamol products may need to be considered.
Pseudomonas putida as a platform for medium‐chain length α,ω‐diol production: Opportunities and challenges
Authors: Lu Chunzhe , Wijffels Rene H. , Martins dos Santos Vitor A. P. , Weusthuis Ruud A. 
Published: March 2024

AbstractMedium‐chain‐length α,ω‐diols (mcl‐diols) play an important role in polymer production, traditionally depending on energy‐intensive chemical processes. Microbial cell factories offer an alternative, but conventional strains like Escherichia coli and Saccharomyces cerevisiae face challenges in mcl‐diol production due to the toxicity of intermediates such as alcohols and acids. Metabolic engineering and synthetic biology enable the engineering of non‐model strains for such purposes with P. putida emerging as a promising microbial platform. This study reviews the advancement in diol production using P. putida and proposes a four‐module approach for the sustainable production of diols. Despite progress, challenges persist, and this study discusses current obstacles and future opportunities for leveraging P. putida as a microbial cell factory for mcl‐diol production. Furthermore, this study highlights the potential of using P. putida as an efficient chassis for diol synthesis.
Engineering the carbon and redox metabolism of Paenibacillus polymyxa for efficient isobutanol production
Authors: Meliawati Meliawati , Volke Daniel C. , Nikel Pablo I. , Schmid Jochen 
Published: March 2024

AbstractPaenibacillus polymyxa is a non‐pathogenic, Gram‐positive bacterium endowed with a rich and versatile metabolism. However interesting, this bacterium has been seldom used for bioproduction thus far. In this study, we engineered P. polymyxa for isobutanol production, a relevant bulk chemical and next‐generation biofuel. A CRISPR‐Cas9‐based genome editing tool facilitated the chromosomal integration of a synthetic operon to establish isobutanol production. The 2,3‐butanediol biosynthesis pathway, leading to the main fermentation product of P. polymyxa, was eliminated. A mutant strain harbouring the synthetic isobutanol operon (kdcA from Lactococcus lactis, and the native ilvC, ilvD and adh genes) produced 1 g L−1 isobutanol under microaerobic conditions. Improving NADPH regeneration by overexpression of the malic enzyme subsequently increased the product titre by 50%. Network‐wide proteomics provided insights into responses of P. polymyxa to isobutanol and revealed a significant metabolic shift caused by alcohol production. Glucose‐6‐phosphate 1‐dehydrogenase, the key enzyme in the pentose phosphate pathway, was identified as a bottleneck that hindered efficient NADPH regeneration through this pathway. Furthermore, we conducted culture optimization towards cultivating P. polymyxa in a synthetic minimal medium. We identified biotin (B7), pantothenate (B5) and folate (B9) to be mutual essential vitamins for P. polymyxa. Our rational metabolic engineering of P. polymyxa for the production of a heterologous chemical sheds light on the metabolism of this bacterium towards further biotechnological exploitation.
Human α‐synuclein overexpression upregulates SKOR1 in a rat model of simulated nigrostriatal ageing
Authors: Morales‐Prieto Noelia , Bevans Rebekah , O'Mahony Adam , Barron Aaron , Giles Doran Conor , McCarthy Erin , Concannon Ruth M. , Goulding Susan R. , McCarthy Cathal M. , Collins Louise M. , Sullivan Aideen M. , O'Keeffe Gerard W. 
Published: March 2024

AbstractParkinson's disease (PD) is characterised by progressive loss of dopaminergic (DA) neurons from the substantia nigra (SN) and α‐synuclein (αSyn) accumulation. Age is the biggest risk factor for PD and may create a vulnerable pre‐parkinsonian state, but the drivers of this association are unclear. It is known that ageing increases αSyn expression in DA neurons and that this may alter molecular processes that are central to maintaining nigrostriatal integrity. To model this, adult female Sprague–Dawley rats received a unilateral intranigral injection of adeno‐associated viral (AAV) vector carrying wild‐type human αSyn (AAV‐αSyn) or control vector (AAV‐Null). AAV‐αSyn induced no detrimental effects on motor behaviour, but there was expression of human wild‐type αSyn throughout the midbrain and ipsilateral striatum at 20 weeks post‐surgery. Microarray analysis revealed that the gene most‐upregulated in the ipsilateral SN of the AAV‐αSyn group was the SKI Family Transcriptional Corepressor 1 (SKOR1). Bioenergetic state analysis of mitochondrial function found that SKOR1 overexpression reduced the maximum rate of cellular respiration in SH‐SY5Y cells. Furthermore, experiments in SH‐SY5Y cells revealed that SKOR1 overexpression impaired neurite growth to the same extent as αSyn, and inhibited BMP‐SMAD‐dependent transcription, a pathway that promotes DA neuronal survival and growth. Given the normal influence of ageing on DA neuron loss in human SN, the extent of αSyn‐induced SKOR1 expression may influence whether an individual undergoes normal nigrostriatal ageing or reaches a threshold for prodromal PD. This provides new insight into mechanisms through which ageing‐related increases in αSyn may influence molecular mechanisms important for the maintenance of neuronal integrity.
Telehealth and delivery of alcohol use disorder treatment in the Veterans Health Administration
Authors: Perumalswami Ponni V. , Adams Megan A. , Frost Madeline C. , Holleman Rob , Kim Hyungjin Myra , Zhang Lan , Lin Lewei (Allison) 
Published: March 2024

AbstractBackgroundThe use of telehealth treatment of alcohol use disorder (AUD) has increased since the start of the COVID‐19 pandemic. However, it is unclear which patients are using telehealth and how telehealth visits are associated with treatment duration. This study examined characteristics associated with telehealth use among Veterans Health Administration patients receiving AUD treatment.MethodsUsing a national retrospective cohort study, we examined data from March 01, 2020 to February 28, 2021 to: First, identify patient characteristics associated with (a) any telehealth versus only in‐person care for AUD treatment, and (b) video (≥1 video visit) versus only telephone visits for AUD treatment (≥1 telephone visit, no video) among any telehealth users. This analysis used mixed‐effects logistic regression models to adjust for potential correlation across patients treated at the same facility. Second, we assessed whether visit modality was associated with the amount of AUD treatment received (number of AUD psychotherapy visits or medication coverage days). This analysis used mixed‐effects negative binomial regression models.ResultsAmong 138,619 patients who received AUD treatment, 52.8% had ≥1 video visit, 38.1% had ≥1 telephone but no video visits, and 9.1% had only in‐person visits. In the regression analyses, patients who were male or had an opioid or stimulant use disorder (compared to having no non‐AUD substance use disorder) were less likely to receive any telehealth‐delivered AUD treatment compared to only in‐person AUD treatment. Among patients who received any telehealth‐delivered AUD treatment, those who were ≥45 years old (compared to 18–29 years old), Black (compared to White), diagnosed with a cannabis or stimulant use disorder, or diagnosed with a serious mental illness were less likely to receive a video visit than only telephone visits. Receiving any AUD telehealth was associated with receiving more psychotherapy visits and medication coverage days than only in‐person care.ConclusionsTelehealth, a common modality for AUD treatment, supported a greater number of psychotherapy visits and a longer duration of medication treatment for AUD. However, some groups were less likely to receive any video telehealth than telephone visits, suggesting that multiple treatment modalities should remain available to ensure treatment access.