bluuebunny/crossref_metadata_2025_split huggingface dataset:
The antiinflammatory, gastroprotective and antioxidant activities of Hieracium gymnocephalum extract
Authors: Petrović Silvana , Dobrić Silva , Mimica‐Dukić Neda , Simin Nataša , Kukić Jelena , Niketić Marjan 
Published: September 2008

AbstractThe present study investigated the antiinflammatory, gastroprotective and antioxidant activities of a CH2Cl2 extract of western Balkan endemic Hieracium gymnocephalum Griseb. ex Pant. (Compositae). The carrageenan‐induced rat paw oedema test was used as an experimental model for screening the antiinflammatory activity. The extract was administrated p.o. in doses of 25, 50, 100 and 200 mg/kg to rats and its effects compared with indomethacin, used p.o. as a reference drug. The results showed that the investigated extract reduced the oedema in a concentration‐dependent manner. The obtained antiinflammatory effect was 5.9%, 11.7%, 31.2% and 44.1% at doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 100 mg/kg. Indomethacin had a strong antiinflammatory effect of 73.4% at a dose of 8 mg/kg, but caused large gastric lesions. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the antiinflammatory effect was slightly enhanced, but the gastric lesions were significantly reduced. The antioxidant activity of the H. gymnocephalum extract, investigated using DPPH radical assay, OH‐radical assay and TBA‐test, was not substantial. Copyright © 2008 John Wiley & Sons, Ltd.
Effect of Peganum harmala or its β‐carboline alkaloids on certain antibiotic resistant strains of bacteria and protozoa from poultry
Authors: Arshad Najma , Zitterl‐Eglseer Karin , Hasnain Shahida , Hess Michael 
Published: September 2008

AbstractIn the present study the antimicrobial potential of various extracts from 12 medicinal plants has been investigated in vitro on multiple antibiotic resistant pathogens and some selected protozoa isolated from poultry. The initial examination was performed on E. coli (n = 10) using disc and agar well diffusion assays. Only two plants, Peganum harmala (seeds) and Eucalyptus globulus (leaves) showed positive responses. The active extracts were also investigated against an additional 19 bacteria and the clonal cultures of three protozoa (Histomonas meleagridis, Tetratrichomonas gallinarum and Blastocystis sp.). Only Peganum harmala was found to inhibit the growth of all bacteria and protozoa at 0.38–1.55 mg/mL and 0.63–1.65 mg/mL, respectively. To investigate the potential role of alkaloids in crude extracts of Peganum harmala, four known β‐carbolin alkaloids were quantified and their antimicrobial activity was compared using a microdilution assay. Harmaline was found to be in the highest concentration followed by harmine and harmalol, whereas harmane could not be detected. The activity of the pure alkaloids was in the order harmane > harmaline > harmalol ≥ harmine for all bacteria, while for protozoa, it was different depending on the microorganism. It is concluded that Peganum harmala or its alkaloids could probably be used for the control of antibiotic resistant isolates of bacteria as well as protozoa. Copyright © 2008 John Wiley & Sons, Ltd.
The effect of Anethum graveolens L. (dill) on corticosteroid induced diabetes mellitus: involvement of thyroid hormones
Authors: Panda Sunanda 
Published: September 2008

AbstractAn investigation was made to evaluate the role of Anethum graveolens L. (dill) leaf extract in the regulation of corticosteroid‐induced type 2 diabetes mellitus in female rats. In dexamethasone‐treated animals (1 mg/kg for 22 days) an increase in serum concentration of insulin and glucose and in hepatic lipid peroxidation (LPO) was observed. However, there was a decrease in serum concentration of thyroid hormones and in the endogenous antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) in liver. In animals treated with an equivalent amount of dexamethasone for a similar period (22 days) when received the leaf extract (100 mg/kg b.wt/d.) for last 15 days a decrease in the concentration of both serum glucose and insulin was observed, indicating the potential of the plant extract in the regulation of corticosteroid‐induced diabetes. Dexamethasone‐induced alterations in the levels of thyroid hormones as well as in hepatic LPO, SOD, CAT and GSH were also reversed by the plant extract. Copyright © 2008 John Wiley & Sons, Ltd.
Effect of traditional Chinese medicine Shu‐mai‐tang on angiogenesis, arteriogenesis and cardiac function in rats with myocardial ischemia
Authors: Yin Huiqiu , Zhang Jidong , Lin Haiqing , Qiao Yun , Wang Rong , Lu Huixia , Liang Su 
Published: September 2008

AbstractIschemic heart disease is one of the leading causes of morbidity and mortality worldwide. Shu‐mai‐tang (SMT) is a traditional Chinese medicine for the treatment of ischemic heart disease. To better understand the underlying cardioprotection mechanisms of SMT on myocardial ischemia (MI), the effect of SMT on angiogenesis, arteriogenesis and cardiac function was investigated in a rat model of MI, as well as the potential mechanism. Rats with a ligated left anterior descending coronary artery (MI model) were randomized (24 rats/group) to receive SMT/LY294002 [phosphatidylinositol 3‐kinase (PI3K) inhibitor], SMT or no treatment. A sham‐operation group was included. It was demonstrated that 2 and 4 weeks after treatment the oral administration of SMT significantly increased capillaries and arterioles, suppressed myocardial fibrosis, as well as significantly increased cardiac phosphorylation of Akt, vascular endothelial growth factor (VEGF) and platelet‐derived growth factor (PDGF‐BB) levels and functional improvement. PI3K inhibitor down‐regulated SMT‐induced angiogenesis and arteriogenesis. These novel therapeutic properties of SMT to induce the reconstitution of stable blood supply networks, reverse LV remodeling may offer an alternative therapy for the treatment of ischemic heart disease. The potential mechanism may be that SMT promotes VEGF and PDGF‐BB‐mediated angiogenesis and arteriogenesis through the PI3K/Akt signaling pathway. Copyright © 2008 John Wiley & Sons, Ltd.
Convergence and quantum number assignment studies of rovibrational eigenstates in a model of predissociating NeICl van der Waals complex
Authors: Elander Nils , Levin Sergey B. , Yarevsky Evgeny 
Published: September 2008

AbstractThis report details extensions and further analysis of the results presented in an earlier study (Elander et al., Phys Rev A 2001, 64, 012505). Rovibrational resonances in a model of the triatomic van der Waals complex NeICl were studied with a full quantum mechanical, smooth exterior dilation technique realized in a three‐dimensional finite element code. Both exact and approximate results, where Coriolis effects are neglected, are presented, and their structures are discussed. Although the helicity is a good quantum number in a one‐equation approximation, it is here demonstrated that this is not in the case when including Coriolis coupling, that is, couplings to other helicity components. The behavior of the resonance widths and the positions together with the structure of the resonance wave functions and their dependence on the total angular momentum and its projection have been studied. The dependence of the width of a given resonance on the total angular momentum was found to be weak while the dependence on the helicity is stronger. © 2008 Wiley Periodicals, Inc. Int J Quantum Chem, 2009
Anharmonic effects on theoretical IR line shapes of medium strong H(D) bonds
Authors: Issaoui Noureddine , Rekik Najeh , Oujia Brahim , Wójcik Marek J. 
Published: September 2008

AbstractWe extend a quantum nonadiabatic treatment of damped H‐bonds involving combined effects of anharmonicities of both the fast and the slow modes, Fermi resonances and relaxation [Rekik et al., J Mol Liq (in press)] in order to account for stronger H‐bonds. For this purpose, we introduce, in the model, the quadratic modulation of both the angular frequency and the equilibrium position of theX−$\mathop H\limits^{\rightarrow}$…Ystretching mode on the intermonomer$\mathop X\limits^{\leftarrow}- H \ldots \mathop Y\limits^{\rightarrow}$motions to refine the structure of the spectrum, whereas we have considered in our previous work only the linear modulation of the angular frequency of the fast mode. In this approach, the strong anharmonic coupling theory is used through second‐order expansion in the slow‐mode coordinateQof the angular frequency and the equilibrium position of the fast mode. The relaxations of the fast mode (direct damping) and of the H‐bond bridge (indirect damping) are incorporated by aid of previous results [Rekik et al., J Mol Struct 2004, 687, 125]. The spectral density is obtained by Fourier transform of the autocorrelation function of the dipole moment of the fast stretching mode. The numerical calculation shows that the modulation of the angular frequency of the fast mode and its equilibrium position by the slow mode coordinate generate an improvement of the fine structure of the spectrum and also provide a direct evidence of the increase of the level density and the spectral broadening. © 2008 Wiley Periodicals, Inc. Int J Quantum Chem, 2009
Enabling the provision of secure web based m‐health services utilizing XML based security models
Authors: Vouyioukas Demosthenes , Kambourakis George , Maglogiannis Ilias , Rouskas Angelos , Kolias Constantinos , Gritzalis Stefanos 
Published: September 2008

AbstractIt has been generally agreed that the security of electronic patient records and generally e‐health applications must meet or exceed the standard security that should be applied to paper medical records, yet the absence of clarity on the proper goals of protection has led to confusion. The primary purpose of this study was to investigate appropriate security mechanisms, which will help clinical professionals and patients discharge their ethical and legal responsibilities by selecting suitable systems and operating them safely and in short order. Thus, in this paper we propose a security model based on XML with the intention of developing a fast security policy mostly intended for mobile healthcare information systems. The proposed schema consists of a set of principles based on XML security models through the use of partial encryption, signature and integrity services and it was implemented by means of a web‐based m‐health application in a centralized three‐tier architecture utilizing wireless networks environment. Several experiments took place with the aim of measuring the client response time implementing a number of m‐health scenarios. The results showed that the response times required for the fulfilment of a client request with the XML security model are smaller compared to those corresponding to the conventional security mechanisms such as the application of SSL. By selectively applying confidentiality and integrity services either to the medical information as a whole or to some sensitive parts of it, the obtained results clearly demonstrate that XML security mechanisms overwhelm those of SSL and they are suitable for deployment in m‐health applications. Copyright © 2008 John Wiley & Sons, Ltd.
Focused ion beam implantation of Ga in Si and Ge: fluence‐dependent retention and surface morphology
Authors: Gnaser Hubert , Brodyanski Alexander , Reuscher Bernhard 
Published: September 2008

AbstractFocused ion beam implantation of 30‐keV Ga+ ions in single‐crystalline Si and Ge was investigated by SIMS, using Cs+ primary ions for sputtering. Nine different implantation fluences ranging from 1 × 1013 to 1 × 1017 Ga+‐ions/cm2 were used, with implanted areas of 40 × 40 µm2. The Ga concentration distributions of these implants were determined by SIMS depth profiling. Such 30‐keV Ga implantations were also simulated by a dynamic Monte‐Carlo code that takes into account the gradual change of the near‐surface composition due to the Ga incorporation. In both approaches, an essentially linear increase of the Ga peak concentrations with fluence is found up to ∼1 × 1016cm−2; for higher fluences, the Ga content approaches a saturation level which is reached at about (1–2) × 1017cm−2. The measured and simulated peak concentrations of the Ga distributions are in good agreement. The most probable ranges obtained from the experiments correspond closely with the respective values from the simulations. The surface morphology caused by Ga+ implantation was investigated by atomic force microscopy (AFM). The AFM data indicate that for low fluences (<3 × 1015cm−2) the surface within the implanted areas is growing outward (i.e. is swelling). For increasingly higher fluences, sputter‐induced erosion of the surface becomes dominant and distinct craters are formed for fluences above ∼1 × 1016cm−2. At the boundary of the implanted region a wall‐like structure is found to form upon Ga implantation; its height is growing with increasing fluence, reaching a value of ∼15 nm at 1 × 1017 Ga+‐ions/cm2. Copyright © 2008 John Wiley & Sons, Ltd.
Screen of Genes Linked to High-Sugar Content in Stems by Comparative Genomics
Authors: Calviño Martín , Bruggmann Rémy , Messing Joachim 
Published: September 2008

AbstractOne of the great advantages of the fully sequenced rice genome is to serve as a reference for other cereal genomes in particular for identifying genes linked to unique traits. A trait of great interest is reduced lignocellulose in the stem of related species in favor of fermentable sugars as a source of biofuels. While sugarcane is one of the most efficient biofuel crops, little is known about the underlying gene repertoire involved in it. Here, we take advantage of the natural variation of sweet and grain sorghum to uncover genes that are conserved in rice, sorghum, and sugarcane but differently expressed in sweet versus grain sorghum by using a microarray platform and the syntenous alignment of rice and sorghum genomic regions containing these genes. Indeed, enzymes involved in carbohydrate accumulation and those that reduce lignocellulose can be identified.
Characterization of the paracrine effects of human skeletal myoblasts transplanted in infarcted myocardium
Authors: Perez‐Ilzarbe Maitane , Agbulut Onnik , Pelacho Beatriz , Ciorba Cristina , Jose‐Eneriz Edurne San , Desnos Michel , Hagège Albert A. , Aranda Pablo , Andreu Enrique J. , Menasché Philippe , Prósper Felipe 
Published: September 2008

AbstractBackground:The discrepancy between the functional improvements yielded experimentally by skeletal myoblasts (SM) transplanted in infarcted myocardium and the paucity of their long‐term engraftment has raised the hypothesis of cell‐mediated paracrine mechanisms.Methods and results:We analyzed gene expression and growth factors released by undifferentiated human SM (CD56+), myotubes (SM cultured until confluence) and fibroblasts‐like cells (CD56−). Gene expression revealed up‐regulation of pro‐angiogenic (PGF), antiapoptotics (BAG‐1, BCL‐2), heart development (TNNT2, TNNC1) and extracellular matrix remodelling (MMP‐2, MMP‐7) genes in SM. In line with the gene expression profile, the analysis of culture supernatants of SM by ELISA identified the release of growth factors involved in angiogenesis (VEGF, PIGF, angiogenin, angiopoietin, HGF and PDGF‐BB) as well as proteases involved in matrix remodelling (MMP2, MMP9 and MMP10) and their inhibitors (TIMPs). Culture of smooth muscle cells (SMC), cardiomyocytes (HL‐1) and human umbilical vein endothelial cells (HUVECs) with SM‐released conditioned media demonstrated an increased proliferation of HUVEC, SMC and cardiomyocytes (p<0.05) and a decrease in apoptosis of cardiomyocytes (p<0.05). Analysis of nude rats transplanted with human SM demonstrated expression of human‐specific MMP‐2, TNNI3, CNN3, PGF, TNNT2, PAX7, TGF‐β, and IGF‐1 1 month after transplant.Conclusions:Our data support the paracrine hypothesis whereby myoblast‐secreted factors may contribute to the beneficial effects of myogenic cell transplantation in infarcted myocardium.
Hierarchy in the zone-block lithospheric structure of Central and Eastern Asia
Authors: Seminskii K.Zh. 
Published: September 2008

Abstract
The lithospheric structure in Asia has been analyzed in terms of sizes of blocks and mobile zones between them on local (northeastern Olkhon area in western Baikal region), regional (Baikal region), and global (Central and Eastern Asia) scales. A single approach to reference mapping was used to update Sadovskii’s hierarchy of blocks and to rank the mobile zones. According to the updated model, the 1ithospheric structure of Central and Eastern Asia includes eleven hierarchic levels.
Structure of terranes in a Jurassic accretionary prism in the Sikhote-Alin-Amur area: implications for the Jurassic geodynamic history of the Asian eastern margin
Authors: Kemkin I.V. 
Published: September 2008

Abstract
A Jurassic accretionary prism in the Sikhote-Alin-Amur area is an assembly of terranes, which are tectonic-sedimentary complexes consisting of multiple strongly deformed fragments of an oceanic plate. The stack of tectonic-stratigraphic units (complexes) in the prism section records its geodynamic history, each unit being signature of a geologic event on the Paleoasian eastern margin. The succession of accretion events brought together fragments of a Paleozoic oceanic plateau in the Early Jurassic and abyssal plain fragments of different ages in Middle and Late Jurassic time.
The age and origin of volcanics in the Riphean section of the Siberian craton (western Baikal area)
Authors: Gladkochub D.P. , Mazukabzov A.M. , Donskaya T.V. , De Waele B. , Stanevich A.M. , Pisarevsky S.A. 
Published: September 2008

Abstract
In the western Baikal area, the structural position, composition, and age of volcanic rocks in the section of the Riphean margin of the Siberian craton were studied. The age of these rocks, earlier assigned to the Khotskaya Formation, is estimated at 274±3 Ma (concordia constructed over 11 zircon grains, SHRIMP-II). The geochemical and isotope compositions of volcanics evidence that they resulted from the melting of mantle source of EM-I type contaminated by crustal material. The intrusion of volcanics into the upper crustal horizons might have been caused by the evolution of the Permian active margin of the Siberian continent, which took place on the background of the closure of the Mongolo-Okhotsk ocean. Based on the results of studies, a new subvolcanic complex of Early Permian age has been recognized in the region, which includes the above-mentioned volcanics and earlier described porphyrite dikes of close age in the Sharyzhalgai uplift. The data obtained disprove the concept that the studied volcanics are of Riphean age; therefore, the available stratigraphic charts of the Siberian Precambrian must be revised.
A NOTE ON SPACES Cp(X)K-ANALYTIC-FRAMED IN ℝX
Authors: FERRANDO J. C. , KĄKOL J. 
Published: September 2008

AbstractThis paper characterizes the K-analyticity-framedness in ℝX for Cp(X) (the space of real-valued continuous functions on X with pointwise topology) in terms of Cp(X). This is used to extend Tkachuk’s result about the K-analyticity of spaces Cp(X) and to supplement the Arkhangel ′skiĭ–Calbrix characterization of σ-compact cosmic spaces. A partial answer to an Arkhangel ′skiĭ–Calbrix problem is also provided.
Role of sphingosine 1-phosphate receptor expression in eosinophils of patients with allergic rhinitis, and effect of topical nasal steroid treatment on this receptor expression
Authors: Mackle T , Gendy S S , Walsh M , McConn-Walsh R , Costello R W , Walsh M-T 
Published: September 2008

AbstractObjective:Recent research has indicated that sphingosine 1-phosphate plays a role in allergy. This study examined the effect of allergen challenge on the expression of sphingosine 1-phosphate receptors on the eosinophils of allergic rhinitis patients, and the effect of steroid treatment on this expression.Study design:A prospective, non-randomised study.Methods:The study had three parts. Firstly, sphingosine 1-phosphate receptor expression on the eosinophils of allergic rhinitis patients and control patients was determined. Secondly, sphingosine 1-phosphate receptor expression was quantified pre- and post-allergen challenge, before and after a short course of fluticasone propionate; all patients underwent symptom scoring and peak nasal inspiratory flow measurement pre- and post-allergen challenge, both before and after steroid or saline treatment. Thirdly, the effect of sphingosine 1-phosphate on eosinophil migration was examined.Results:The eosinophils of both allergic rhinitis patients and controls expressed sphingosine 1-phosphate1, 3, 4, and 5. Eosinophils from all allergic rhinitis patients demonstrated up-regulation in sphingosine 1-phosphate expression after allergen challenge. These changes were statistically very significant for sphingosine 1-phosphate1, 4, and 5, and moderately significant for sphingosine 1-phosphate3. Sphingosine 1-phosphate receptor expression up-regulation was abolished in the steroid-treated group after allergen challenge; however, the saline-treated group showed no change in sphingosine 1-phosphate receptor expression after allergen challenge. Peak nasal inspiratory flow scores were significantly diminished after allergen challenge prior to treatment, but not after a course of topical nasal steroids. Sphingosine 1-phosphate induced eosinophil chemotaxis was increased following allergen challenge in allergic rhinitis subjects.Conclusions:Local intranasal steroid therapy acts directly to block allergen-induced up-regulation of sphingosine 1-phosphate receptors on the peripheral eosinophils of allergic rhinitis patients, and this is coincident with post-challenge peak nasal inspiratory flow measurement improvements. These observations support the idea that such an increase in sphingosine 1-phosphate receptor expression is clinically relevant in allergic rhinitis, with potential consequences for eosinophil migration and survival.
The structure and nature of phonological neighbourhoods in children's early lexicons
Authors: ZAMUNER TANIA S. 
Published: September 2008

ABSTRACTThis research examines phonological neighbourhoods in the lexicons of children acquiring English. Analyses of neighbourhood densities were done on children's earliest words and on a corpus of spontaneous speech, used to measure neighbours in the target language. Neighbourhood densities were analyzed for words created by changing segments in word-onset position (rhyme neighbours as in pin/bin), vowel position (consonant neighbours as in pin/pan/) and word-offset position (lead neighbours as in pin/pit). Results indicated that neighbours in children's early lexicons are significantly more often distinguished in word-onset position (rhyme neighbours) and significantly less often distinguished in word-offset position (lead neighbours). Moreover, patterns in child language are more extreme than in the target language. Findings are discussed within the PRIMIR framework (Processing Rich Information from Multidimensional Interaction Representations; Werker & Curtin, 2005). It is argued that early perceptual sensitivity aids lexical acquisition, supporting continuity across speech perception and lexical acquisition.