bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meaningful Work, Career Fit, and Professional Well-Being of Pediatric Academicians in the United States
Authors: Slovin Ariella , Bora Samudragupta , Barber John R. , Kloster Heidi M. , Rogers Stephen R. , Green Cori M. , Selbst Steven M. , Kemper Kathi J. , Serwint Janet R. , Garg Arvin , Lim Sylvia W. 
Published: April 2024

OBJECTIVE
Examine associations between time spent in academic activities perceived as meaningful and professional well-being among academic pediatrics faculty.

METHODS
The sample comprised 248 full-time pediatric faculty (76% female, 81% white, non-Hispanic, 41% instructor or assistant professor) across the United States who completed an online survey in November 2019. Survey items included sociodemographic and professional characteristics, professional well-being measures (Stanford Professional Fulfillment Index; Maslach Burnout Inventory; Intention to Leave Academic Medicine), perceived meaningfulness of academic activities and assigned time to those activities. We defined global career fit as total percentage time assigned to professional activities considered meaningful by individuals, and activity-specific career fit as percentage time assigned to each meaningful professional activity.

RESULTS
As global career fit scores increased, professional fulfillment increased (r = 0.45, P &lt; .001), whereas burnout (r = −0.29, P &lt; .001) and intention to leave (r = −0.22, P &lt; .001) decreased. Regarding activity-specific career fit, for individuals who considered patient care meaningful, as assigned time to patient care increased, professional fulfillment decreased (r = −0.14, P = .048) and burnout (r = 0.16, P = .02) and intention to leave (r = 0.26, P &lt; .001) increased. There was no significant correlation between assigned time for teaching, research, or advocacy and professional well-being. Faculty were less likely to intend to leave academic medicine as assigned time increased for administrative or leadership activities if considered meaningful (r = −0.24, P = .01).

CONCLUSIONS
Time assigned to meaningful work activities may relate to professional well-being of academic pediatrics faculty. More time assigned to patient care, despite being meaningful, was associated with poor self-reported professional well-being. Effort allocation among diverse academic activities needs to be optimized to improve faculty well-being.
Subjetividades. Un estudio a partir de experiencias en la práctica del deporte social comunitario
Authors: Bolívar-Silva Oscar David , Porras-Ramírez Andrea , Bajonero Rafael Antonio , Gambasica-Díaz Diana Carolina 
Published: April 2024

Cada día es más frecuente la práctica deportiva en las sociedades, puesto que se ha convertido en un fenómeno cultural con superlativa acogida en la población, inclusive en los procesos de paz realizados en el país era constituido como un pilar fundamental de la formación de la población en el posconflicto. Este posicionamiento no es para menos, puesto que el deporte social comunitario promueve acciones para mitigar problemáticas y necesidades presentes en las comunidades, por medio de la formación de sujetos y proyectos hacía le mejoramiento de la calidad de vida. Bajo este marco, se propuso descubrir las subjetividades que emergen de la práctica deportiva, a través de una investigación cualitativa de índole hermenéutico, que permitió compilar relatos de vida de deportistas comunitarios (estudiantes del Programa de Gestión Deportiva de la Universidad Nacional Abierta y a Distancia), a partir de sus experiencias, se descubren los sentimientos, relaciones y posicionamiento social que estos tienen, aproximándose al sentido subjetivo del deportista consigo mismo, con el otro y desde el papel que juega en su comunidad. De esta forma, se logra evidenciar características propias de los sujetos en sus prácticas, al igual que argumentar desde la academia la implementación del deporte como una estrategia de construcción, formación y comprensión social.
Limitations of Diagnosis of Ischemic Left Ventricular Dysfunction Using the Values of Strain, Twist and Untwist in Patients With Myocardial Infarction of Various Localization
Authors: Shvets D. A. , Povetkin S. V. 
Published: April 2024

Aim. To compare capabilities for diagnosing regional and global myocardial dysfunction using the values of longitudinal and circular strain, left ventricular (LV) torsion and untwisting in patients with myocardial infarction (MI) of various locations.Material and methods. Patients included in the study (n=121) were divided into three groups: patients with unstable angina (n=30), patients with anterior MI (n=45), and patients with inferior MI (n=46). Clinical, laboratory and instrumental test were performed, including echocardiography. For a quantitative analysis of LV contractility, the maximum systolic peaks of regional and global longitudinal and circular strain, systolic and diastolic rotation, LV torsion and untwisting were measured.Results. Anterior MI was characterized by injury of the LV apical segments, while inferior MI was characterized by injury of the basal segments. In anterior MI, the longitudinal strain was reduced less than 14.5% and circular strain less than 19.3% in the apical segment of the LV anteroseptal wall (ASW). In akinesia of the LV ASW apical segment, longitudinal and circular strains were reduced less than 10%. The magnitude of the circular strain of the LV ASW apical segment (diagnostic threshold 19.3%, sensitivity (Se) 87%, specificity (Sp) 90%) was superior to that of the longitudinal strain as a diagnostic marker for regional ischemic dysfunction in anterior MI. The magnitude of the circular strain of the basal segment of the LV inferior wall in inferior MI has a greater diagnostic value for identifying regional systolic dysfunction than the value of the longitudinal strain of this LV segment. The diagnostic threshold was 17.3%, Se 79%, Sp 80%.Conclusion. A decrease in the circular strain of the LV ASW less than 19.3% in the LV apical segment is more specific (Sp 90%) for diagnosing regional systolic dysfunction in anterior MI than a decrease in longitudinal strain. A circular strain value of less than 17.3% in the basal segment of the LV inferior wall is more specific (Sp 80%) than the longitudinal strain of this segment for diagnosing regional systolic dysfunction in inferior MI. Predominant injury to the LV apex in anterior MI can cause systolic and diastolic myocardial dysfunction, which is manifested by a decrease in LV circular deformation, torsion and untwisting.
Short Registry of Terminal Forms of Chronic Heart Failure in the Samara Region
Authors: Rubanenko O. A. , Skripnik I. V. , Matuchina K. V. , Rubanenko A. O. , Davydkin I. L. , Benyan A. S. , Duplyakov D. V. 
Published: April 2024

Aim. To study the clinical characteristics and prognosis of patients with functional class (FC) III-IV chronic heart failure (CHF) who meet the criteria for inclusion in the palliative care program.Material and methods. A short registry of severe CHF forms was conducted at 60 outpatient and inpatient clinics in the Samara region for one month (16.05.2022-15.06.2022). The registry included patients with FC III-IV CHF who sought medical help during that period. Lethal outcomes were assessed at 90 days after the inclusion in the registry using the Mortality Information and Analytics system.Results. 591 patients (median age, 71.0 [64.0; 80.0] years were enrolled, including 339 (57.4%) men, of which 149 (24.1%) were of working age (under 65 years). The main cause of CHF was ischemic heart disease (64.5%). 229 (38.7%) patients had left ventricular ejection fraction <40%. During the past year, 513 (86.8%) patients had at least one hospitalization for decompensated CHF. 45.7% of patients had hydrothorax, and 11.3% of patients had ascites. Low systolic blood pressure was observed in more than 25% of patients; 14.2% required in-hospital inotropic support; and 9.1% received it on the outpatient basis. 4.2% of patients received outpatient oxygen support and 0.8% required the administration of narcotic analgesics. 12 (1.9%) patients were on the waiting list for heart transplantation. In this study, there was an inconsistency in the number of patients with ventricular tachycardia and/or left bundle branch block (LBBB) who were implanted with cardiac resynchronization therapy devices (CRTD) or an implantable cardioverter defibrillator (ICD), a total of 19 patients (11 patients with CRTD and 8 patients with ICD), while 58 (9.8%) patients had indications for CRTD/ICD implantation. Within 90 days from inclusion in the registry, 59 (10.0%) patients died. According to binary logistic regression analysis, the presence of LBBB, hydrothorax, the requirement for outpatient oxygen support, and a history of cardiac surgery were associated with a high risk of death.Conclusion. Patients with severe forms of CHF require not only adequate drug therapy, but also dynamic clinical observation supplemented with palliative care aimed at improving the quality of life, including the ethical principles of shared decision-making and advance care planning to identify the priorities and goals of patients in relation to their care.
MATERNIDADES, FEMINISMOS E RELAÇÕES DE GÊNERO: CONSTRUÇÕES DO PASSADO; QUESTÕES DO PRESENTE
Authors: Soares Ana Carolina Eiras Coelho , Cardoso Vanessa Clemente 
Published: April 2024

O presente dossiê busca trabalhos que pensem nas relações estabelecidas pelas questões das maternidades, seus discursos históricos e as atuações dos feminismos, tanto no passado, quanto em seus impactos no mundo contemporâneo. É, portanto, uma proposta de intercâmbio interdisciplinar que agrega uma extensa pauta no que tange às noções das maternidades e dos feminismos. Os diversos feminismos contemporâneos, em especial os surgidos através das mídias digitais, entendem que a “maternidade”, agora entendida como ato plural de “fazer social” – e, embora seja uma questão importante para as mulheres nem sempre recebeu a atenção reflexiva pelos feminismos – e que apresenta uma série de demandas e debates ainda em voga na sociedade ocidental, com especial atenção para a latinidade, tais como: controle de natalidade; maternidade compulsória; papel social das mulheres; atuação no mercado de trabalho; amamentação; divisão de gênero nas relações de cuidado, e diversas outras que, urgentemente, ganham força e se apresentam com pautas diversificadas e apropriações discursivas que ganham especificidades próprias em diferentes contextos.
A presença de múltiplos saberes, narrativas, linguagens e estudos acerca das questões que envolvem as relações de gênero, maternidades, discursos históricos e feminismos envolve um amplo debate sobre emoções, afetos, sexualidades, racialidades, etarismos, corpos(as), orientações sexuais, entre outros fatores, que uma vez naturalizada a função materna cada vez mais como sendo “função biológica da mulher”, foram retirados do cenário de debates públicos, obliterando lugares de fala e possibilidades de atuações políticas.
Aberto à participação de pesquisadoras/es aos diversos aspectos possíveis dessa ampla temática, esse dossiê visa compreender ações e temporalidades dos discursos e seus impactos na história e no mundo contemporâneo, com políticas e culturas ainda muito marcadas pelas desigualdades de gênero, violências e assimetrias de vida na nossa sociedade.
As novas topografias teóricas sobre maternidades e feminismos, realizadas desde final dos anos 90 que tem se aprofundado em diversas abordagens, possibilitam analisar tais temas, em especial na América Latina, através de uma série de marcadores sociais da diferença, tais como: raça, sexualidades, corpo, identidade de gênero e relações de poder, ampliando consideravelmente a potencialidade das categorias analíticas e das pesquisas realizadas, na construção de narrativas múltiplas e plurais, colaborando com a revisão de diferentes e áreas do conhecimento acadêmico e científico.
Is bone-grafting or bone-healing adjunct always necessary for the treatment of non-union ? Our experience of treating non-unio by primary osteosynthesis in chronically neglected shaft of femure fractures
Authors: Jain Mohit J , Mehta Vatsal J , Nayak Hardik J , Vadodaria Gaurav M , Shah Malkesh D , Patel Dhavalkumar J 
Published: April 2024

Non-union of bone is a frightening consequence of fracture management. This condition usually occurs when the body's natural healing process cannot bridge the gap and restore the continuity of the bone. Non-infected non-union can be classified into two main types: Hypertrophic and Atrophic. Our research aims to determine the results after primary osteosynthesis without bone graft or adjuvant in neglected shaft femur fracture aseptic non-unions.We performed a retrospective chart review to include consequative series of neglected shaft of femur fracture non-unions treated by primary osteosynthesis surgery during a span of 3 years from 2020-2022. We excluded cases with partial union, identifiable systemic or external causes of non-union and those belonging to pediatric & elder age groups.We included 13 neglected cases of shaft femur fractures. Out of 13 patients, 7 (53.8%) were males. The mean age was 43 (range 23-55) years, and the mean injury presentation interval was 9 (range 4-18) months. Nine had hypertrophic, 2 had atrophic and 1 had undefinable non-union. At one year follow-up, 12 out of 13 showed completely united fractures with no functional limitation. Only one patient showed delayed union and eventually united Discussion: Treating non-union requires a comprehensive approach tailored to the fracture personality. The original AO principles (1960) of fracture healing remain the mainstay of fracture healing. Besides the gold standard autologus bone graft, many biological agents like BMP are currently available to augment bone healing. However, most of them have failed to provide consistent and promising results when there is an absence of innate osteogenic potential.In our experience, an excellent union rate can be achieved without the use of bone-grafting or bone-healing adjuvants in chronically neglected long bone fractures where no previous surgical attempt was made in absence of systemic and exteral risk factors for non-union.
Assessing Representativeness of Seriously Ill Patient Survey Responders in a Pragmatic Clinical Trial
Authors: Chau Aaron J. , Hays Ron , Walling Anne M. , Gibbs Lisa , Rahimi Maryam , Sudore Rebecca L. , Wenger Neil S. ,   UC Health Care Planning Study Investigators
Published: April 2024

Objective
Pragmatic trials often implement an intervention across a population of patients but require information unavailable at the population level that must be reported by a subset of patients. In this pragmatic clinical trial, we compared characteristics of seriously ill patients with those who completed a survey evaluating advance care planning across 3 academic health systems.

Methods
A deliberate process including health system and external stakeholders and patients was used to design materials for and the approach to seriously ill patients. We developed a survey and conducted a multistep process to identify seriously ill primary care patients. We evaluated the relationships of age, gender, race and ethnicity, and vulnerability using the social vulnerability index in this population, and explored the representativeness of survey respondents compared with the underlying seriously ill population in terms of age, race and ethnicity, and vulnerability measured.

Results
About 5% (8707 patients) of the primary care population was classified as seriously ill, 5351 were mailed a survey and 1100 provided survey responses. Hispanic and Black patients were younger than White patients, and Black and Hispanic patients were more vulnerable than White and Asian patients and patients of other races. Representativeness was high across age and race and ethnicity, although White and Hispanic patients were more likely to respond than Black and Asian patients and patients of other races. Vulnerability in the surveyed sample was nearly identical to the population.

Conclusions
A tailored survey and recruitment strategy yielded a representative sample of seriously ill, largely older, primary care respondents in the context of a pragmatic clinical trial.
Design of Lipid Nanoparticles of mRNA Vaccine against Respiratory Syncytial Virus by Bioinformatics in Egypt
Authors: Kassab Mohammed 
Published: April 2024

Background:
Respiratory syncytial virus[ RSV] is a lethal overwhelming defectiveness that influences people all over the world. The infection gets down in the lower respiratory tract and does not disperse to the remainder of the body.
The objective of the study:
Bioinformatics was used to create an mRNA vaccine against the Respiratory syncytial virus( RSV).
Methodology:
Lipid nanoparticle vaccines containing the Respiratory syncytial virus&#039;s surface fusion protein&#039;s mRNA were created for the current screening experimental investigation. Lipid nanoparticles[ LNP] with a particle size of around 90 nanometres that were created using the hot micro-emulsion process comprise the current vaccine delivery system. In stages 1 and 2 of clinical trials, the immunogenicity of the current mRNA RSV vaccine was evaluated.
Results:
The current vaccine demonstrated 81% immunogenicity in animal testing, but only 69% in stages 1 and 2 of clinical trials. Its side effects were manageable. The results persisted for a while. In the current trial, the vaccination proved effective as a preventative measure against RSV infection. The current immunization lacks antibody-dependent enhancement, which causes non-protective antibodies to develop. These non-neutralizing antibodies worsen infection by enhancing viral entrance and replication in the host cells, activating cytokines and the complement cascade through the production of immunological complexes, or both. However, the current LPN-RSV mRNA vaccine of the surface fusion protein resulted in the formation of potent neutralizing antibodies with persistent protection, especially for newborns and elderly individuals who get the ideal dose regimen.
Conclusion:
The invention of the LNP-mRNA RSV vaccine, which might prevent RSV-caused bronchiolitis and fatal pneumonia, made the current study promising
Weighted Gene Coexpression Network Analysis Identifies an Immunogenic Cell Death Signature for Predicting Prognosis and Therapeutic Responses in Glioblastoma
Authors: Chen Lei , Zhang Runze , Jin Qiu , Wang Xiuyu , Zhang Bingjie , Feng Xuequan 
Published: April 2024

Abstract
Background: Studies have shown that inducing immunogenic cell death (ICD) breaks down the immunosuppressive tumor microenvironment and controls tumor progression, but the relationship between ICD and glioblastoma (GBM) was unclear. Therefore, this study was designed to investigate the potential prognostic value of ICD-related genes in GBM.
Methods: A total of 34 ICD-related genes were collected from various sources. Utilizing public databases, relevant data about GBM were extracted and analyzed by the weighted gene co-expression network analysis (WGCNA) to section prognosis-related ICD gene modules. A risk model was developed using the Lasso algorithm, and its accuracy was confirmed by including an independent Gene Expression Omnibus (GEO) dataset. Enrichment analysis was employed to analyze the biological functions and pathways associated with these signals, and the tumor immune infiltration capacity was evaluated. The R package oncoPredict was used to infer the drug sensitivity of patients in different risk groups using the GDSC2 database with expression profiling data.
Results: Thirty-four ICD-related genes were differentially expressed in GBM samples and two gene modules significantly associated with prognosis were identified. Base on the two modules, VDR and CIDEB were identified as two signature genes for the prognostic prediction of GBM. Multivariate Cox analysis demonstrated that this signature was an independent factor for evaluating overall survival of GBM, and ROC curves also supported an effective prediction of the signature (1-year AUC: 0.667; 3-year AUC:0.727; 5-year AUC: 0.762). We observed that the high-risk group had higher immune cell infiltration and sensitivity to some drugs.
Conclusion: This work developed a novel ICD-related prognostic model for GBM patients. Our findings highlighted the potential of using ICD as a promising prognostic indicator in GBM, contributing to the current understanding of the intricate interplay between ICD and tumor microenvironment.
CNN and LSTM Approach for Soil Nutrient analysis for Sugarcane Crop
Authors: J Kavitha K , K Krishna Prasad 
Published: April 2024

Abstract

A new paradigm has been adopted in agricultural techniques, tools, and technology. To guarantee the implementation of site-specific crop management, which includes soil nutrient treatments according to crop requirements, precision agriculture is crucial. Soil nutrients are a major component in determining the growth of precision agriculture, which has gained global attention. One of the main challenges is more effective nutrient content detection as it guides well-planned nutrient-level-boosting routines. Many approaches, such using research labs and additional mobile labs, haven't shown to be very useful in helping farmers control their soil fertility. Taking advantage of the breakthroughs is severely hampered by factors like lack of knowledge and distance from research centers. In the work proposed, LSTM based RNN is employed to predict the Ph and nutrient values of the soil measured through microcontroller using sensor from the agricultural field. At the same time, RELU-CNN approach is applied to the soil images for measuring the same values. The values obtained from both the approaches are compared against each other so that the method may be made directly available to the farmers for evaluating the nutrient level of the soil and take necessary action. The approaches are measured in terms of quality parameters Recall, F1-Score, Accuracy, Precision and RMS value.