bluuebunny/crossref_metadata_2025_split huggingface dataset:
Charting The Course; A Systematic Review On Healthcare Leadership Styles And Their Symphony With Employee Satisfaction In Saudi Arabian Health Administration
Authors: Abdulaziz Salih Alghaylani,  , Majed Ali Alsulaimani,  , Fahad Mohammad ALgethamim,  , Majed Abdullah Al Zahrani,  , Ahmed Abdullah Al Thumali,  , Majed Abdullah Altowairqi,  , Abdullah Ali Ghalib,  , Abdallah Waslallah Awad Aljrdahi,  , Mohammed Salem Althomali,  , Meshal Eid Faleh Althagfi,  , Hatem Swalih Al Themali,  , Wafi Suhail Dehaim Alotaibi  
Published: February 2024

Background; Effective leadership is essential for the success of healthcare organizations, particularly in Saudi Arabia where the healthcare sector is undergoing rapid transformation. Leadership styles within health administration roles play a significant role in shaping employee satisfaction and organizational outcomes. Understanding prevalent leadership styles and their impact on employee satisfaction is crucial for enhancing the overall performance of healthcare organizations in Saudi Arabia.
Purpose; The study aimed to evaluate prevalent healthcare leadership styles and their impact on employee satisfaction in health administration roles in Saudi Arabia's healthcare sector.
Method; A cross-sectional descriptive research design was employed, and data were collected from healthcare employees in government hospitals in Taif, Saudi Arabia. A structured questionnaire was used to assess leadership styles and employee satisfaction, and data were analyzed using descriptive statistics, correlation coefficient analysis, independent t-tests, and multiple linear regressions.
Results; The study identified three prevalent healthcare leadership styles; Autocratic, Democratic, and Laissez-Faire. Significant positive correlations were found between these leadership styles and employee satisfaction. Autocratic, Democratic, and Laissez-Faire leadership styles were all positively associated with employee satisfaction. Gender differences in leadership styles and job satisfaction were also explored, revealing variations across genders within healthcare administration roles.
Conclusion; The study underscores the importance of effective leadership in healthcare administration for promoting employee satisfaction. Healthcare organizations in Saudi Arabia should prioritize leadership development programs tailored to enhance leadership skills and foster positive leadership practices. By understanding and implementing effective leadership strategies, healthcare administrators can create supportive work environments that contribute to overall employee satisfaction and organizational success.
Efecto de las obligaciones tributarias del sector artesanal de Tornería, Portoviejo
Authors: Rezabala Castro Paul Enrique , Mera Plaza Carmen Liliana 
Published: February 2024

La presente investigacion tiene como principal objetivo el determinar el efecto que tiene las obligaciones tributarias con el sector artesanal de las tornerias en Portoviejo, teniendo una metodologia basada en una investigación descriptiva y documental, a su vez el diseño empleado fue no experimental, transaccional descriptivo y de tipo cualitativos ayudándonos a responder y analizar las distintas preguntas de la problemática, por cuanto se combinan el análisis de documentos y técnicas de campo, tales como: la encuesta y la entrevista; los datos se procesaron a través de técnicas cualitativas: análisis de los contenidos, crítico y comparativo; en la ciudad de Portoviejo existen 16 tornerías donde realizan todo tipo de piezas, en cada una de ellas existen de 3 a 9 trabajadores dependiendo el tamaño de estos establecimientos que en su gran mayoría son microempresas, la población a investigar será a los 16 dueños o gerentes de las tornerías más sus colaboradores; concluyendo así en que la mayoría de tornerías si mantienen sus obligaciones tributarias, sin embargo, se encontró que el impacto del incumplimiento en el déficit de recaudación tributaria, se debe a la falta de conocimiento adecuado de las obligaciones tributarias por parte del artesano, por lo cual resultó en retrasos e inconsistencias, y al mismo tiempo resultó en multas y sanciones.
Análisis descriptivo de las publicaciones sobre violencia en las relaciones de pareja adolescentes españoles escolarizados en educación secundaria en los últimos años
Authors: Reyes Álvarez Patricia , Soriano Díaz Andrés , Martínez-Heredia Nazaret , González-Gijón Gracia 
Published: February 2024

The main objective of this study is to analyse the existing scientific production in the Web of Science and Scopus databases on violence in adolescent intimate partner relationships in Spain, from 2015 to 2022. The final sample consisted of 25 documents from both databases. The study was carried out through a quantitative analysis of the selected publications. It concludes with the identification of a greater number of publications in the Web of Science database on this topic and a greater bibliographic production in the years 2020 and 2021. Violence in adolescent intimate partner relationships is a social and global health problem that requires research in order to deepen our knowledge and prevention. It is necessary to broaden the line of study on violence in adolescent relationships in Spain, since it is at this age when the way in which certain behaviours originating in relationships are interpreted will influence the way in which young people conceive their future relationships, their love for them and, more importantly, their love and respect for themselves.
El objetivo principal de este estudio es analizar la producción científica existente en las bases de datos Web of Science y Scopus sobre la violencia en las relaciones de pareja de adolescentes en España, desde 2015 a 2022. 25 documentos de ambas bases de datos han conformado la muestra final. El estudio se ha realizado mediante un análisis cuantitativo de las publicaciones seleccionadas. Se concluye con la identificación de un mayor número de publicaciones en la base de datos Web of Science sobre dicha temática y una mayor producción bibliográfica en los años 2020 y 2021. La violencia que se produce en las relaciones de pareja adolescentes es un problema social y de salud mundial que requiere de investigación para poder profundizar en su conocimiento y prevención. Es necesario ampliar la línea de estudio sobre la violencia en las relaciones de pareja de adolescentes que se dan en España, ya que es a esta edad cuando la manera de interpretar determinadas conductas que se originan en las relaciones de pareja influirá en la forma en la que los jóvenes conciben sus futuras relaciones, el amor hacia estas y más importante, el amor y respeto hacia ellos mismos.
PARTO HUMANIZADO: SIGNIFICACIÓN DE LA VALORACIÓN HUMANISTICA EN LA CALIDAD DE CUIDADO
Authors: Lisia Alfaro Ana 
Published: February 2024

El propósito de este artículo fue Generar una teoría sustantiva sobre el parto humanizado desde la significación de la valoración humanística en la calidad de cuidado en el Hospital Nacional Nuestra señora de Fátima de Cojutepeque Cuscatlán, El Salvador. Se profundizó en las temáticas Teoría del Cuidado Humano de Jean Watson (1988), La Génesis de Enfermería como semilla de la Humanidad y el Parto Humanizado: Su historia y evolución. La perspectiva metodológica fue la cualitativa, el paradigma asumido el postpositivista, con el uso del método fenomenológico-hermenéutico con enfoque interpretativo, siguiendo a Van Manen (2003) para buscar el conocimiento a partir de los elementos epistemológicos que lo definen. El escenario estuvo representado por el servicio de Ginecobstetricia del Hospital Nacional Nuestra señora de Fátima de Cojutepeque Cuscatlán, El Salvador. Las informantes fueron tres (3): Parturienta (1) y enfermeras (2), seleccionadas porque sus testimonios son portadores del conocimiento y experiencia acerca del parto humanizado. El instrumento fue la entrevista en profundidad, como técnica de análisis se utilizó la categorización y la triangulación hermenéutica. Las categorías que emergieron fueron: Conocimiento de la parturienta y de la enfermera sobre el parto humanizado, Vínculo Afectivo Parturienta enfermera, Acompañamiento a las parturientas en el Trabajo de Parto y Comunicación Enfermera-parturienta. Se generó una Teoría sustantiva con dos ejes articuladores: 1)-Parto Humanizado y 2)-Relación terapéutica de apoyo por el profesional de enfermería, destacándose que el logro de partos y nacimientos satisfactorios se basa en el principio Bioético de Autonomía. Se destaca como reflexión que el modelo de parto humanizado implica un cambio de paradigma del embarazo, parto, puerperio y de la relación con el recién nacido, que tienen un efecto determinante en la salud y bienestar físico y emocional de la mujer el bebé y la familia.
Novel diagnostic biomarkers related to necroptosis and immune infiltration landscape in acute myocardial infarction
Authors: Wu Wenfa , Fan Hongxing , Cen Junlin , Huang Pei , Li Guidong , Tan Yanping , Liu Gen , Hong Baoshan 
Published: February 2024

Background
Acute myocardial infarction (AMI) can occur suddenly, which may induce deadly outcomes, and the population suffering from AMI presents a younger trend. Necroptosis, the new cell necrosis type, is associated with the pathogenic mechanisms of diverse cardiovascular diseases (CVDs). Its diagnostic value and molecular mechanisms in AMI are still unclear. Objective: This study focused on determining key necroptosis-related genes as well as immune infiltration in AMI.

Methods
We first examined the GSE66360 dataset for identifying necroptosis-related differentially expressed genes (NRDEGs). Thereafter, GO and functional annotation were performed, then a PPI network was built. In addition, “CIBERSORT” in R was applied in comparing different immune infiltration degrees in AMI compared with control groups. The receiver operating characteristic (ROC) curve was plotted to evaluate whether hub NRDEGs could be used in AMI diagnosis. Associations of immune cells with candidate NRDEGs biomarkers were examined by Spearman analysis. Finally, hub NRDEGs were validated by cell qPCR assays and another two datasets.

Results
A total of 15 NRDEGs were identified and multiple enrichment terms associated with necroptosis were discovered through GO and KEGG analysis. Upon module analysis, 10 hub NRDEGs were filtered out, and the top six hub NRDEGs were identified after ROC analysis. These top six NRDEGs might have a certain effect on modulating immune infiltrating cells, especially for mast cells activated, NK cells activated and neutrophils. Finally, two AMI datasets and qPCR assay came to identical findings.

Conclusion
Our results offer the reliable molecular biomarkers and new perspectives for necroptosis in AMI, which lay a certain foundation for developing novel anti-AMI therapeutic targets.
Emulsifying and Lipid Peroxidation Inhibitory Activities of Chicken Head Protein Hydrolysate Using a Combination of Papain and Bromelain Enzymes
Authors: Syahdan Moch. Geerhan Miraja , Andiana Pramudya , Radiati Lilik Eka 
Published: February 2024

Protein hydrolysis is a method used to produce protein hydrolysates containing simple peptides and free amino acids. The chicken head is one of the by-products that contain a high protein concentration so it can be use as a raw material for protein hydrolysate with functional properties and as a lipid peroxidation inhibitor. The aim of this research was determination to determine the emulsifying and lipid peroxidation inhibitory properties in chicken head protein hydrolysate using a combination of papain and bromelain enzymes. The method used in this research was a laboratory experiment using a completely randomized design (CRD) consisting of 4 treatments and 5 replications, consisting of T1 (without hydrolysis), T2 (75% papain enzyme and 25% bromelain enzyme), T3 (papain enzyme 50% and bromelain enzyme 50%), and T4 (papain enzyme 25% and bromelain enzyme 75%). The difference in the concentration ratio of papain enzyme and bromelain enzyme in chicken head protein hydrolysate gave a very significant difference (P<0.01) in Electrical conductivity (EC), a significant difference (P<0,05) in lipid peroxidation inhibitory activity and emulsion activity, and no significant difference (P>0,05) in emulsion stability. Chicken head protein hydrolysate shows potential as an emulsifier and lipid peroxidation inhibitor.
Awareness and Practices of Senior High School Students and Teachers on Environmental Education: Basis for Instructional Materials Development
Authors: Galorio Ian Jake N. , Naling Chennie S. 
Published: February 2024

Environmental education in the Philippines has been incorporated into different course curricula, including life and physical sciences. This study evaluated the awareness and practices of senior high school students and teachers in environmental education. The study included 125 senior high school students and 25 teachers from Montevista Stand Alone Senior High School.
The study found that 44% of the teacher-respondents were between 41-50 years old, while 51.20% of the student-respondents were between 17-18 years old. The teacher-respondents demonstrated a high level of awareness in environmental concepts and the state of the environment, with an overall mean of 4.34. The student-respondents showed a moderate level of awareness, with an overall mean of 3.18. The teacher-respondents "always" practiced taking action to solve environmental problems, with an overall mean of 4.52, while the student-respondents "often" did so, with an overall mean of 3.80.
No statistically significant difference was found in the level of awareness of environmental concepts and the state of the environment among teachers when grouped according to gender (p-value = 0.207) or grade level taught (p-value = 0.910). Similarly, for students, no statistically significant difference was found when grouped according to grade level (p-value = 0.162) or age (p-value = 0.213). The awareness of environmental concepts was significantly and positively related to the need for a high degree of commitment among both teachers (r=0.455; p=0.022) and students (r=0.885; p=0.000).
Based on the findings, the researcher recommends developing instructional materials for environmental education that aim to maintain and increase students' understanding and capacities in relation to environmental problems and environmental sustainability principles.
Effect of Organic Manures and Bio-Fertilizers on Growth, Yield and Quality of Kharif Cowpea [Vigna unguiculata (L.)]
Authors: Patel Z. B. , Chaudhari P. P. , Patel P. R. , Kumawat Laxman , Katiyar Drishty 
Published: February 2024

A field experiment was conducted at Agronomy Instructional Farm of SDAU, Sardarkrushinagar, Gujarat, India during kharif season of 2020-2021. The experiment consisting nine treatments viz., T1-Absolute control, T2-100% RDF (20 kg N + 40 kg P2O5 ha-1), T3- FYM @ 5.0 t ha-1, T4-FYM @ 2.5 t ha-1 + Rhizobium + PSB, T5-vermicompost @ 2.0 t ha-1, T6-vermicompost @ 1.0 t ha-1 + Rhizobium + PSB, T7-castor cake @ 2.0 t ha-1, T8-castor cake @ 1.0 t ha-1 + Rhizobium + PSB, T9-Ghan Jeevamrut @ 250 kg ha-1 at sowing time + Seed treatment with Beejamrut @ 200 ml kg-1 seed+ Jeevamrut @ 500 lit ha-1 with irrigation at sowing and 30 DAS were tested in randomized block design with four replications. The result revealed that the application of T8-castor cake @ 1.0 t ha-1 + Rhizobium + PSB showed significant improvement on plant height, number of branches per plant, dry matter accumulation, number of pods per plant, number of seeds per pod, length of pod and seed yield per plant whereas, application of T4-FYM @ 2.5 t ha-1 + Rhizobium + PSB gave significantly higher number of root nodules per plant, fresh and dry weight of root nodules. it is concluded that higher yield from kharif cowpea could be obtained by applying either castor cake @ 1.0 t ha-1 or FYM @ 2.5 t ha-1 along with Rhizobium + PSB in loamy sand soils of North Gujarat.
Design Through Making: An Introduction
Authors: Sheil Bob 
Published: January 2006

AbstractShould a sound understanding and experience of making underpin design skills? In an age of design data, what does the architect still have to gain from the physical and tacit? Bob Sheil, guest‐editor of Design through Making, outlines the ideas behind the issue and how they have prompted intriguing and impassioned responses from a diverse array of contributors. Copyright © 2005 John Wiley & Sons, Ltd.
A novel homeobox mutation in thePITX2gene in a family with Axenfeld‐Rieger syndrome associated with brain, ocular, and dental phenotypes
Authors: Idrees Faisal , Bloch‐Zupan Agnes , Free Samantha L. , Vaideanu Daniela , Thompson Pamela J. , Ashley Paul , Brice Glen , Rutland Paul , Bitner‐Glindzicz Maria , Khaw Peng T. , Fraser Scott , Sisodiya Sanjay M. , Sowden Jane C. 
Published: January 2006

AbstractAxenfeld‐Rieger Syndrome (ARS) is a genetically heterogeneous birth defect characterized by malformation of the anterior segment of the eye associated with glaucoma. Mutation of thePITX2homeobox gene has been identified as a cause of ARS. We report a novel Arg5Trp missense mutation in thePITX2homeodomain, which is associated with brain abnormalities. One patient had a small sella turcica likely to reflect hypoplasia of the pituitary gland and consistent with the critical role identified forPitx2in pituitary development in mice. Two patients had an enlarged cisterna magna, one with a malformed cerebellum, and two had executive skills deficits one in isolation and one in association with a below average intellectual capacity. The mutation caused a typical ARS ocular phenotype. All affected had iris hypoplasia, anterior iris to corneal adhesions, and corectopia. The ocular phenotype varied significantly in severity and showed some asymmetry. All affected also had redundant peri‐umbilical skin, a hypoplastic maxilla, microdontia, and hypodontia missing between 20 and 27 teeth with an unusual pattern of tooth loss. Dental phenotypes were documented as they are often poorly characterized in ARS patients. All affected individuals showed an absence of first permanent molars with variable absence of other rarely absent teeth: the permanent upper central incisors, maxillary and mandibular first and second molars, and the mandibular canines. Based on the distinctive dental anomalies, we suggest that the dental phenotype can assist in predicting the presence of aPITX2mutation and the possibility of brain abnormalities. © 2006 Wiley‐Liss, Inc.
A genome‐wide linkage analysis of dementia in the Amish
Authors: Hahs Daniel W. , McCauley Jacob L. , Crunk Amy E. , McFarland Lynne L. , Gaskell Perry C. , Jiang Lan , Slifer Susan H. , Vance Jeffery M. , Scott William K. , Welsh‐Bohmer Kathleen A. , Johnson Stephanie R. , Jackson Charles E. , Pericak‐Vance Margaret A. , Haines Jonathan L. 
Published: January 2006

AbstractSusceptibility genes for Alzheimer's disease are proving to be highly challenging to detect and verify. Population heterogeneity may be a significant confounding factor contributing to this difficulty. To increase the power for disease susceptibility gene detection, we conducted a genome‐wide genetic linkage screen using individuals from the relatively isolated, genetically homogeneous, Amish population. Our genome linkage analysis used a 407‐microsatellite‐marker map (average density 7 cM) to search for autosomal genes linked to dementia in five Amish families from four Midwestern U.S. counties. Our highest two‐point lod score (3.01) was observed at marker D4S1548 on chromosome 4q31. Five other regions (10q22, 3q28, 11p13, 4q28, 19p13) also demonstrated suggestive linkage with markers having two‐point lod scores >2.0. While two of these regions are novel (4q31 and 11p13), the other regions lie close to regions identified in previous genome scans in other populations. Our results identify regions of the genome that may harbor genes involved in a subset of dementia patients, in particular the North American Amish community. © 2006 Wiley‐Liss, Inc.
Possible association of the alpha‐2A adrenergic receptor gene (ADRA2A) with symptoms of attention‐deficit/hyperactivity disorder
Authors: Wang Bing , Wang Yufeng , Zhou Rulun , Li Jun , Qian Qiujin , Yang Li , Guan Lili , Faraone Stephen V. 
Published: January 2006

AbstractA dysfunction of the central noradrenergic system has long been suggested to be involved in attention‐deficit/hyperactivity disorder (ADHD). Pharmacological evidence from animal studies and clinical practice has identified the alpha‐2A adrenergic receptor gene (ADRA2A) as a candidate gene in ADHD. Some findings from Caucasian populations seem to support a role for this gene in ADHD. The current study first examined the association of the ADRA2A MspI and DraI polymorphisms with ADHD in the Han Chinese population, which differs quite substantially from the Caucasian population in the frequencies of alleles at these polymorphisms. No biased transmission of alleles of either polymorphism was observed using transmission disequilibrium test (TDT) analysis in a sample of 268 nuclear families with an ADHD proband; however, haplotype analysis only identified a trend toward over‐transmission of the M/C haplotype to probands with the combined subtype of ADHD (χ2 = 3.233, P = 0.072). The mm genotype of the MspI polymorphism was also marginally related (P = 0.051) to lower ADHD symptom scores in a sample of 559 Chinese children with ADHD, which is inconsistent with data from Caucasian samples. Our results provide weak evidence for a possible role of ADRA2A in ADHD symptom expression. © 2006 Wiley‐Liss, Inc.
Association between tryptophan hydroxylase gene polymorphisms and attention deficit hyperactivity disorder in Chinese Han population
Authors: Li Jun , Wang Yufeng , Zhou Rulun , Zhang Haobo , Yang Li , Wang Bing , Faraone Stephen V. 
Published: January 2006

AbstractAttention deficit hyperactivity disorder (ADHD) is a severe behavioral disorder in children known to have a substantial genetic component. Prior studies have implicated serotonin genes in the etiology of ADHD but have not examined tryptophan hydroxylase (TPH), which is a rate‐limiting enzyme in serotonin biosynthesis. The current study examined the relationship between the A218C and A‐6526G polymorphisms of the TPH gene and ADHD. Three hundred sixty‐two unrelated ADHD probands and their biological parents were recruited to participate in this study. No biased transmission of any allele of the two polymorphisms was observed using TDT analysis. However, haplotype analyses found that the rare 218A/‐6526G haplotype was significantly not transmitted to probands with ADHD (χ2 = 4.4995, P = 0.034), regardless of subtype. Although this finding for ADHD in the Chinese Han population. © 2006 Wiley‐Liss, Inc.
Hyperprolinemia is not associated with childhood onset schizophrenia
Authors: Jacquet Hélène , Rapoport Judith L. , Hecketsweiler Bernadette , Bobb Aaron , Thibaut Florence , Frébourg Thierry , Campion Dominique 
Published: January 2006

AbstractIn a previous report [Jacquet et al., 2005] we have shown that mild to moderate hyperprolinemia resulting from several alterations (either a complete deletion or missense mutations) of the proline dehydrogenase (PRODH) gene located on chromosome 22q11 is a risk factor for schizoaffective disorder but not for DSM3 R schizophrenia or bipolar disorder. We now report that hyperprolinemia is not associated with childhood onset schizophrenia (COS). © 2006 Wiley‐Liss, Inc.