bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optical density of high fluence autoradiographic images to study boron microdistribution: validation of the technique in tissue sections
Authors: Espain M. S. , Viglietti J. S. , Vidal C. , Martin D. , Trivillin V. A. , Monti Hughes A. , Palmieri M. A. , De Leo L. , Garabalino M. A. , Curotto P. , Thorp S. I. , Pozzi E. C. C. , Saint Martin G. , Portu A. M. 
Published: March 2024

The distribution of boron in biological samples coming from BNCT protocols can be determined by the analysis of autoradiographic images formed by nuclear tracks on polymeric detectors. The tissue section is first explored to delimit regions of interest (ROIs), and then it is removed in order to reveal nuclear tracks through an etching process. A quantitative autoradiographic technique was developed to measure the boron concentration in the sample by counting the nuclear tracks on the detector. However, under certain circumstances, rapid measurements of boron distribution are required. For that purpose, a methodology was developed, allowing a rapid and easy determination of boron concentration and distribution in a tissue section by measuring grey levels in the corresponding high fluence autoradiographic image (HFA). The grey levels are then converted to optical density values which are then correlated with boron concentration values. In order to validate the technique, consecutive sections of several tissue samples were analyzed by the conventional counting method and by HFA. The image analysis and boron concentration estimation can be carried out in under 15 min, and relative differences between zones can be easily determined.
Intelligent structure prediction and visualization analysis of non-coding RNA in osteosarcoma research
Authors: Chen Longhao , He Liuji , Liu Baijie , Zhou Yinghua , Lv Lijiang , Wang Zhiguang 
Published: March 2024

BackgroundOsteosarcoma (OS) is the most common bone malignant tumor in children and adolescents. Recent research indicates that non-coding RNAs (ncRNAs) have been associated with OS occurrence and development, with significant progress made in this field. However, there is no intelligent structure prediction and literature visualization analysis in this research field. From the perspective of intelligent knowledge structure construction and bibliometrics, this study will comprehensively review the role of countries, institutions, journals, authors, literature citation relationships and subject keywords in the field of ncRNAs in OS. Based on this analysis, we will systematically analyze the characteristics of the knowledge structure of ncRNAs in OS disease research and identify the current research hotspots and trends.MethodsThe Web of Science Core Collection (WoSCC) database was searched for articles on ncRNAs in OS between 2001 and 2023. This bibliometric analysis was performed using VOSviewers, CiteSpace, and Pajek.ResultsThis study involved 15,631 authors from 2,631 institutions across 57 countries/regions, with a total of 3,642 papers published in 553 academic journals. China has the highest number of published papers in this research field. The main research institutions include Nanjing Medical University (n = 129, 3.54%), Shanghai Jiao Tong University (n = 128, 3.51%), Zhengzhou University (n = 110, 3.02%), and China Medical University (n = 109, 2.99%). Oncology Letters (n =139, 3.82%), European Review for Medical Pharmacological Sciences (120, 3.31%), and Molecular Medicine Reports (n = 95, 2.61%) are the most popular journals in this field, with Oncotarget being the most co-cited journal (Co-Citation = 4,268). Wei Wang, Wei Liu, and Zhenfeng Duan published the most papers, with Wang Y being the most co-cited author. “miRNA”, “lncRNA” and “circRNA” are the main focuses of ncRNAs in OS studies. Key themes include “migration and invasion”, “apoptosis and proliferation”, “prognosis”, “biomarkers” and “chemoresistance”. Since 2020, hotspots and trends in ncRNA research in OS include “tumor microenvironment”, “immune” and “exosome”.ConclusionThis study represents the first comprehensive bibliometric analysis of the knowledge structure and development of ncRNAs in OS. These findings highlight current research hotspots and frontier directions, offering valuable insights for future studies on the role of ncRNAs in OS
“There is nothing that can prevent me from supporting her:” men’s perspectives on their involvement and support of women’s use of topical therapy for cervical precancer treatment in Kenya
Authors: Mungo Chemtai , Adewumi Konyin , Adoyo Everlyn , Zulu Graham , Goraya Supreet Kaur , Ogollah Cirillus , Omoto Jackton , Ferrari Renée M. , Rahangdale Lisa 
Published: March 2024

PurposeCervical cancer disproportionately impacts women in low- and middle-income countries (LMICs). The World Health Organization’s (WHO) 90/70/90 strategy aims to eliminate cervical cancer by 2030 by increasing HPV vaccination coverage to 90%, screening 70% of eligible women, and effectively treating 90% of those with abnormal results by 2030, potentially preventing 62 million deaths in LMICs. LMICs, however, struggle with limited access to cervical precancer treatment, in part due to a lack of trained professionals and weak health systems. Effective non-surgical, self-administered, which have demonstrated efficacy in high-income countries, could bridge the treatment gap in LMICs and may be more scalable and cost-effective than provider-administered therapies. To inform feasibility studies in LMICs, data are needed on the role of male partners in influencing the acceptability and uptake of self-administered topical therapies, including their support of recommended abstinence and contraception guidelines associated with these therapies.MethodsBetween November 2022 and April 2023, we conducted five focus group discussions (FGDs) with men aged 25 to 65 years in Kenya to explore their perspective and perceived support regarding their female partners using topical self-administered therapies for cervical precancer treatment. The FGDs were moderated by local qualitative research assistants and conducted in local languages, transcribed, coded, and analyzed using qualitative description.ResultsThirty-nine male participants meeting the eligibility criteria participated in five FGDs. The mean age of participants was 42.5 years. Most participants, 79.5%, had a female partner with a history of cervical precancer treatment, 5.1% did not, and 15.4% were unsure of their female partner’s prior precancer treatment history. The study aimed to assess men’s support of their female partners’ use of topical therapies for treating cervical precancer. We find that male participants strongly express acceptance and willingness to support their wives or partners in using such therapies, if available. Reported supportive behavior included permitting the use of the therapies and support of maintaining abstinence during the recommended times. Additionally, participants desired male involvement in clinic and community-based education about topical therapies to facilitate widespread support.ConclusionThe use of self-administered topical therapies for cervical precancer treatment, if supported by efficacy studies in LMICs, may support achieving the WHO’s 2030 goal of 90% treatment access. We find that with adequate education, men express overwhelming support of their female partner’s use of topical therapies, including adherence to abstinence and contraception guidelines.
Protein hydrolysates enhance recovery from drought stress in tomato plants: phenomic and metabolomic insights
Authors: Leporino Marzia , Rouphael Youssef , Bonini Paolo , Colla Giuseppe , Cardarelli Mariateresa 
Published: March 2024

IntroductionHigh-throughput phenotyping technologies together with metabolomics analysis can speed up the development of highly efficient and effective biostimulants for enhancing crop tolerance to drought stress. The aim of this study was to examine the morphophysiological and metabolic changes in tomato plants foliarly treated with two protein hydrolysates obtained by enzymatic hydrolysis of vegetal proteins from Malvaceae (PH1) or Fabaceae (PH2) in comparison with a control treatment, as well as to investigate the mechanisms involved in the enhancement of plant resistance to repeated drought stress cycles. MethodsA phenotyping device was used for daily monitoring morphophysiological traits while untargeted metabolomics analysis was carried out in leaves of the best performing treatment based on phenotypic results.ResultsPH1 treatment was the most effective in enhancing plant resistance to water stress due to the better recovery of digital biomass and 3D leaf area after each water stress event while PH2 was effective in mitigating water stress only during the recovery period after the first drought stress event. Metabolomics data indicated that PH1 modified primary metabolism by increasing the concentration of dipeptides and fatty acids in comparison with untreated control, as well as secondary metabolism by regulating several compounds like phenols. In contrast, hormones and compounds involved in detoxification or signal molecules against reactive oxygen species were downregulated in comparison with untreated control.ConclusionThe above findings demonstrated the advantages of a combined phenomics-metabolomics approach for elucidating the relationship between metabolic and morphophysiological changes associated with a biostimulant-mediated increase of crop resistance to repeated water stress events.
Current knowledge of human Mpox viral infection among healthcare workers in Cameroon calls for capacity-strengthening for pandemic preparedness
Authors: Nka Alex Durand , Bouba Yagai , Fokam Joseph , Ka'e Aude Christelle , Gabisa Jeremiah Efakika , Mandeng Nadia , Mfonkou Delors Jacques Toumansie , Ambe Chenwi Collins , Mballa Mpouel Marie-Laure , Djikeussi Tatiana , Tchounga Boris Kevin , Ayuk Ngwese Derrick Tambe , Njume Debimeh , Mbala Nomo Sonia Emmanuelle , Ngoufack Jagni Semengue Ezechiel , Tiotsia Tsapi Armand , Fokou Bernadette Bomgning , Simo Kamdem Ingrid Koster , Tommo Tchouaket Michel Carlos , Takou Désiré , Pabo Willy , Sosso Samuel Martin , Tandi Erick , Esso Linda , Etoundi Mballa Georges Alain , Zoung-Kanyi Bissek Anne-Cecile , Gregory Edie Halle-Ekane , Ndembi Nicaise , Colizzi Vittorio , Perno Carlo-Federico , Ndjolo Alexis 
Published: March 2024

IntroductionAn increased incidence of human Monkeypox (Mpox) cases was recently observed worldwide, including in Cameroon. To ensure efficient preparedness and interventions in the health system, we sought to assess the knowledge of Mpox's transmission, prevention, and response among healthcare workers (HCWs) in Cameroon.MethodsA cross-sectional online survey was conducted among HCWs in Cameroon using 21-item questions adapted from the United States Centers for Disease Control and Prevention (US-CDC) standard questionnaire on Mpox. The overall knowledge of Mpox was assessed by cumulative score and categorized as excellent (≥80%, 17/21) or good (≥70%, ≥15/21) knowledge. The regression analysis was used to identify the predictors of Mpox knowledge.ResultsThe survey enrolled 377 participants, but only responses from 342 participants were analyzed. Overall, 50.6% were female participants, and 59.6% aged 30 years or younger. The majority of the participants were medical doctors (50.3%); most worked in central-level hospitals (25.1%) and had 1–5 years of experience (70.7%). A total of up to 92.7% were aware of Mpox, with social media (58.7%) and radio/television (49.2%) as the main sources. The mean knowledge score was 14.0 ± 3.0 (4 to 20), with only 12.9% having excellent knowledge (≥80%) and 42.1% having good knowledge of Mpox. Younger age (26–30 years old) was associated with good knowledge, while workplace type was associated with excellent knowledge of Mpox (aOR [95% CI]: 4.01 [1.43–11.24]). Knowledge of treatment/management of Mpox was generally poor across the different professional categories.ConclusionKnowledge of Mpox among HCWs is substandard across different professionals. Thus, for optimal preparedness and immediate interventions for Mpox and similar emerging pathogens, capacity-strengthening programs should be organized for HCWs while encouraging scientific literature and organizational social media websites.
A Cybersecurity Collaborative Model: Best Practices Sharing Among South African Tourism and Hospitality Businesses
Authors: Gundu Tapiwa 
Published: March 2024

In an increasingly interconnected digital landscape, cybersecurity has emerged as a paramount concern for South African tourism and hospitality businesses, especially those mostly serving international travellers who depend on online services for bookings and payments. This abstract introduces a comprehensive research study that centres on developing a collaborative cybersecurity model. The primary objective of this model is to facilitate the exchange of best practices among South African tourism establishments, thereby fortifying their collective defences against evolving cyber threats. This research study is based on a systematic literature review that encompasses a diverse array of tourism and hospitality businesses, including hotels, travel agencies, and tour operators. The study delves into existing collaborative initiatives, explores the perceived advantages of information sharing, and examines the challenges that may hinder the effective implementation of collaborative cybersecurity practices. The literature highlighted numerous cybersecurity risks associated with these types of businesses but also revealed a common shortage of dedicated cybersecurity resources and expertise. Collaborative models are regarded as a promising avenue to address these deficits. Businesses actively participating in collaborative networks report tangible benefits, including improved threat intelligence, cost-effective cybersecurity solutions, and enhanced capabilities for incident response. The outcomes of this research endeavour aspire to offer practical insights and actionable recommendations for South African tourism and hospitality businesses, policymakers, and industry associations seeking to cultivate a culture of cybersecurity collaboration. Ultimately, the collaborative model advocated herein contributes to the creation of a more secure online environment for local and international tourists visiting South Africa. This, in turn, safeguards the reputation and long-term sustainability of the tourism and hospitality sector in the country.
Sustainability of Urban Patterns Identity; Komotini-Greece
Authors: TACHİR Gildis 
Published: March 2024

ABSTRACT
The change in the urban patterns of historical artifacts over time negatively affects the sustainable development of the city. In the study, urban patterns analysis of Komotini, Greece, was divided into regions and the change of historical artifacts in urban patterns development was questioned. It has been determined by transferring to the table systematic that historical artifacts have changed in the urban pattern over time. By preserving the historical buildings and transferring them to the next generations, the sustainable patterns of the cities will be changed.
Wafer reconstitution: embedded multi-die III-V and silicon co-integration platform
Authors: Karve Gauri , Li Yunlong , Motsnyi Vasyl , Wei Wei , Visker Jakob , Chancerel François , Ackaert Jan , Puybaret Renaud , Dutta Barundeb , Sabuncuoglu Tezcan Deniz , Peng Lan , Soussan Philippe , Severi Simone , Osman Haris 
Published: March 2024

Abstract
Co-integration of III-V and silicon on the same substrate can enable many applications in photonics, RF, imaging, and sensing. Wafer reconstitution (WARE) is an embedded multi-die integration platform that allows for the integration of heterogenous materials on 200/300 mm Si substrates. This paper describes an integration flow for InP dies attached to 200 mm silicon. Electrical measurements on InGaAs diodes fabricated on WARE wafers confirm that the performance is similar to devices on native InP substrates.
Developments in angle-independent velocity estimators for blood flow imaging
Authors: Hasegawa Hideyuki 
Published: March 2024

Abstract
The frame rate in ultrasonography is significantly better than those in other medical imaging modalities, such as computed tomography and magnetic resonance imaging, even under a traditional imaging scheme, i.e. line-by-line scanning with a focused transmit beam. However, a higher frame rate would provide more possibilities for the measurement of rapidly altering phenomena, such as cardiovascular dynamics. High-frame-rate imaging with unfocused transmit beams, such as plane and diverging transmit beams, enables an extremely high frame rate of over several thousand frames per second and has been shown to be effective for cardiovascular applications, including blood flow imaging. Although an extremely high temporal resolution is achieved by high-frame-rate ultrasound imaging, conventional methods for blood flow imaging are limited because a velocity component only in the direction of ultrasonic propagation is measured. In this paper, recent developments in angle-independent blood flow imaging using high-frame-rate ultrasound are presented.
Field Evaluation of Land Deterioration in Al - Mohammadi Basin Valley at Western Desert
Authors: Alani Noora Abdulateef , Gharbi Moshtaq Ahmed , Hammadi Mohammed Musa 
Published: March 2024

The recurrent study was in including lots scientific details on land deterioration for Almehmedi valley basin. This basin is represented as distinguish sites because it possesses different morphology, geological properties, climate pattern, various land resources such as soils, vegetation and water resources. Conceptualization of this study was entirely prepared then results were different to discover the range of land degradation using field evolution on this basin, which its area was 1971.49 km2. Therefore basin lands were divided into six land unites via geomorphological terms. These terms were done using optical explanation on Land sat 8 satellite image. These unites are high plateaus, flat plateaus, unbath, valleys, alluvial fans, flood plain. Moreover field investigation was applied using GLASOD physical, biological, chemical and saline deterioration. Thus, their cause was explained and measured the deterioration amounts within land units using tables maps. The research study could clouded basin field spatial differences resulted in differing the valley basin from other lands. Furthermore, it resulted in spatial relations amongst human iturimm and natural in this area.
ASSISTÊNCIA DE ENFERMAGEM À CRIANÇA COM CARDIOPATIA CONGÊNITA SUBMETIDO À TERAPIA DE OXIGENAÇÃO POR MEMBRANA EXTRACORPÓREA (ECMO)
Authors: Marcon Gumildes Carolaine das Graças , Makuch Débora Maria Vargas , Vieira Gabriela Doudat , Jesus Paola Raissa de Oliveira de 
Published: March 2024

As cardiopatias congênitas possuem uma incidência de 1 a cada 100 nascidos vivos, a maioria já com diagnóstico intra-útero, desse modo torna-se necessário um planejamento de cuidados ao recém-nascido acometido pela patologia. Pesquisa transversal, descritiva do tipo documental, realizada em Unidade de Terapia Intensiva Cardíaca de um hospital pediátrico de grande porte no estado do Paraná, com o objetivo de analisar a indicação da terapia de oxigenação por membrana extracorpórea, seus benefícios e principalmente evidenciar a assistência de Enfermagem ao recém-nascido submetido a terapia de oxigenação por membrana extracorpórea em Unidade de Terapia Intensiva Cardíaca. Diante da realização desta pesquisa os principais resultados destacam a importância de prestar uma assistência integral e complexa ao paciente submetido à ECMO, bem como à capacitação adequada do enfermeiro e de sua equipe para o manejo desta terapia e suas peculiaridades, com o intuito de prestar cuidados específicos, visando como resultado final à recuperação do paciente. Conclui-se então, que o paciente submetido à ECMO é um paciente crítico que requer assistência individualizada, tornando-se crucial a realização de um plano de cuidados em sincronia com a equipe multidisciplinar atuante.
Vacuum Ultraviolet Single Photon Ionization and Decomposition of 2-Aminopropionitrile in Astrophysical Objects
Authors: Hrodmarsson Helgi Rafn , Schwell Martin , Fray Nicolas , Guillemin Jean-Claude , Hochlaf Majdi , Zins Emilie-Laure 
Published: March 2024

Abstract
The molecule 2-aminopropionitrile (2-APN; H3CCH(NH2)CN) is a chiral precursor of the amino acid alanine and could play an important role in the emergence of the homochirality of life. To date, 2-APN has not yet been detected in the interstellar medium. To address the question of its absence, possibly through destruction by vacuum ultraviolet radiation in astrophysical media, we studied its photoionization and dissociative photoionization in the 9–14 eV (89–137 nm) energy range using photoelectron–photoion coincidence spectroscopy with velocity map imaging. Density functional theory calculations were performed at the PBE0/aug-cc-pVTZ level to determine structures for the various cationic fragments identified experimentally. Their appearance energies were calculated. The adiabatic ionization energy (AIE) of 2-APN is AIE = (9.85±0.01) eV and the appearance energy (AE) of the major fragment ion N≡CC(H)NH2
+ is AE = (10.57±0.01) eV. Both ions, 2-APN+ and N≡CC(H)NH2
+, make up more than 90% of the formed ions. N≡CC(H)NH2
+, an isomer of the protonated HCN dimer, is also formed with high yield in the dissociative photoionization of aminoacetonitrile (NH2CH2CN), another α-aminonitrile observed in Sgr B2(N). Photoion yield spectra have been calibrated to absolute ionization cross sections. From these, we derive photoionization rates in several typical radiation fields relevant to different astrophysical objects. The rates show that, under almost all explored radiation fields, dissociative ionization is the dominant pathway for photoionization, leading to the loss of a methyl group (CH3) to form the planar thermodynamically stable amino cyano methylidynium ion N≡CC(H)NH2
+. The observed absence of 2-APN in Sgr B2 could thus be due to dominant dissociative photoionization.
A New Route to Massive Hot Subdwarfs: Common Envelope Ejection from Asymptotic Giant Branch Stars
Authors: Li Zhenwei , Zhang Yangyang , Chen Hailiang , Ge Hongwei , Jiang Dengkai , Li Jiangdan , Chen Xuefei , Han Zhanwen 
Published: March 2024

Abstract
The hot subdwarf O/B stars (sdO/Bs) are known as extreme horizontal branch stars, which is of great importance in stellar evolution theory. The sdO/Bs are generally thought to have a helium-burning core and a thin hydrogen envelope (M
env < 0.02 M
⊙). In the canonical binary evolution scenario, sdO/Bs are considered to be the stripped cores of red giants. However, such a scenario cannot explain the recently discovered sdO/B binary SMSS J1920, where the strong Ca H and K lines in the spectrum are found. It suggests that this binary likely originated from the recent ejection of the common envelope (CE). In this work, we propose a new formation channel of massive sdO/Bs, namely, sdO/Bs produced from a CE ejection process with an asymptotic giant branch (AGB) star (hereafter the AGB CE channel). We constructed the evolutionary model of sdO/Bs and successfully explained most of the important observed parameters of the sdO/B star in SMSS J1920, including the evolutionary age, sdO/B mass, effective temperature, surface gravity, and surface helium abundance. The minimum sdO/B mass produced from the AGB CE channel is about 0.48 M
⊙. The evolutionary tracks in the

log

T

eff

–
log
g

plane may explain a fraction of the observational samples with high

log

T

eff

and low

log
g

. Considering the wind mass loss of sdO/Bs, the model could produce helium-rich hot subdwarfs with

log
(

n

He

/

n

H

)
≳
−
1

.