bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of internalizing and externalizing symptoms in late childhood from attention-deficit/hyperactivity disorder symptoms in early childhood
Authors: Mlodnicka Agnieszka , Mansolf Maxwell , Chandran Aruna , Aris Izzuddin M. , Calub Catrina A. , Ahmad Shaikh , Shapiro Allison , Cochran David , Restrepo Bibiana , Schmidt Rebecca , Hertz-Picciotto Irva , Bennett Deborah , Gold Diane R. , O’Shea T. Michael , Leve Leslie , Schweitzer Julie B. 
Published: March 2024

Abstract
Limited analyses based on national samples have assessed whether early attention-deficit/hyperactivity disorder (ADHD) symptoms predict later internalizing and externalizing symptoms in youth and the influence of sex and pubertal timing on subsequent psychiatric symptoms. This study analyzed data (n = 2818) from the Environmental influences on Child Health Outcomes Program national cohort. Analyses used data from early childhood (mean age = 5.3 years) utilizing parent-reported ADHD symptoms to predict rates of internalizing and externalizing symptoms from late childhood/adolescence (mean age = 11.9 years). Within a subsample age at peak height velocity (APHV) acted as a proxy to assess pubertal timing from early childhood (mean age = 5.4 years) to adolescence (mean age = 12.3 years). Early-childhood ADHD symptoms predicted later psychiatric symptoms, including anxiety, depression, aggressive behavior, conduct problems, oppositional defiant disorder, and rule-breaking behavior. Earlier APHV was associated with increased Conduct Disorder symptoms from late childhood to adolescence for females only. A stronger relation between ADHD symptoms and later aggression was observed in females with earlier APHV, whereas this same pattern with aggression, conduct problems and depression was observed in males with later APHV. Clinicians should consider that both young girls and boys with elevated ADHD symptoms, particularly with off-set pubertal timing, may be at risk for later psychiatric symptoms.
Evaluation of the Empirical Scaling Factor of Joule Heating Rates in TIE‐GCM With EISCAT Measurements
Authors: Günzkofer Florian , Liu Huixin , Stober Gunter , Pokhotelov Dimitry , Borries Claudia 
Published: March 2024

AbstractJoule heating is one of the main energy inputs into the thermosphere‐ionosphere system. Precise modeling of this process is essential for any space weather application. Existing thermosphere‐ionosphere models tend to underestimate the actual Joule heating rate quite significantly. The Thermosphere‐Ionosphere‐Electrodynamics General‐Circulation‐Model applies an empirical scaling factor of 1.5 for compensation. We calculate vertical profiles of Joule heating rates from approximately 2,220 hr of measurements with the EISCAT incoherent scatter radar and the corresponding model runs. We investigate model runs with the plasma convection driven by both the Heelis and the Weimer model. The required scaling of the Joule heating profiles is determined with respect to the Kp index, the Kan‐Lee merging electric field EKL, and the magnetic local time. Though the default scaling factor of 1.5 appears to be adequate on average, we find that the required scaling varies strongly with all three parameters ranging from 0.46 to ∼20 at geomagnetically disturbed and quiet times, respectively. Furthermore, the required scaling is significantly different in runs driven by the Heelis and Weimer model. Adjusting the scaling factor with respect to the Kp index, EKL, the magnetic local time, and the choice of convection model would reduce the difference between Joule heating rates calculated from measurement and model plasma parameters.
Assessment of the Origin of a Plasma Depletion Band Over the United States During the 8 September 2017 Geomagnetic Storm
Authors: Kil Hyosub , Sun Andrew K. , Lee Woo Kyoung , Chang Hyeyeon , Lee Jiyun 
Published: March 2024

AbstractThe development of an intense total electron content (TEC) depletion band over the United States during the 8 September 2017 geomagnetic storm was understood as the extension of an equatorial plasma bubble (EPB) to midlatitudes in previous studies. However, this study reports non‐EPB aspects within this phenomenon. First, the simultaneous emergence of the TEC depletion band at midlatitudes and EPBs in the equatorial region indicates that the midlatitude TEC depletion band is not initiated by an EPB. Second, the intensification of TEC depletion at midlatitudes during the decay of TEC depletion at intermediate latitudes is anomalous. Third, the location of the TEC depletion band at midlatitudes is inconsistent with the EPB location estimated from zonal plasma motion. Given ionospheric perturbations in North America from the beginning of the storm, it is plausible that the TEC depletion band was locally generated in association with these perturbations.
Involvement of DJ-1 in the pathogenesis of intervertebral disc degeneration via hexokinase 2-mediated mitophagy
Authors: Lin Jialiang , Wang Longjie , Wu Yuhao , Xiang Qian , Zhao Yongzhao , Zheng Xuanqi , Jiang Shuai , Sun Zhuoran , Fan Dongwei , Li Weishi 
Published: March 2024

AbstractIntervertebral disc degeneration (IDD) is an important pathological basis for degenerative spinal diseases and is involved in mitophagy dysfunction. However, the molecular mechanisms underlying mitophagy regulation in IDD remain unclear. This study aimed to clarify the role of DJ-1 in regulating mitophagy during IDD pathogenesis. Here, we showed that the mitochondrial localization of DJ-1 in nucleus pulposus cells (NPCs) first increased and then decreased in response to oxidative stress. Subsequently, loss- and gain-of-function experiments revealed that overexpression of DJ-1 in NPCs inhibited oxidative stress-induced mitochondrial dysfunction and mitochondria-dependent apoptosis, whereas knockdown of DJ-1 had the opposite effect. Mechanistically, mitochondrial translocation of DJ-1 promoted the recruitment of hexokinase 2 (HK2) to damaged mitochondria by activating Akt and subsequently Parkin-dependent mitophagy to inhibit oxidative stress-induced apoptosis in NPCs. However, silencing Parkin, reducing mitochondrial recruitment of HK2, or inhibiting Akt activation suppressed DJ-1-mediated mitophagy. Furthermore, overexpression of DJ-1 ameliorated IDD in rats through HK2-mediated mitophagy. Taken together, these findings indicate that DJ-1 promotes HK2-mediated mitophagy under oxidative stress conditions to inhibit mitochondria-dependent apoptosis in NPCs and could be a therapeutic target for IDD.
Host metabolomic responses in recurrent P. vivax malaria
Authors: Yakubu Michael N. , Mwangi Victor I. , Netto Rebeca L. A. , Alecrim Maria G. C. , Alves Jessica R. S. , Almeida Anne C. G. , Santos Gabriel F. , Lima Gesiane S. , Machado Lucas S. , Koolen Hector H. F. , Guimarães Tiago P. , Chaves Andrea R. , Vaz Boniek G. , Monteiro Wuelton M. , Costa Fabio T. M. , Lacerda Marcus V. G. , Gardinassi Luiz G. , de Melo Gisely C. 
Published: March 2024

AbstractMalaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as a promising tool for combating the disease. The study evaluated plasma metabolomic profiles of patients with recurrent and non-recurrent P. vivax malaria in the Brazilian Amazon. Metabolites extracted from the plasma of P. vivax-infected patients were subjected to LC–MS analysis. Untargeted metabolomics was applied to investigate the metabolic profile of the plasma in the two groups. Overall, 51 recurrent and 59 non-recurrent patients were included in the study. Longitudinal metabolomic analysis revealed 52 and 37 significant metabolite features from the recurrent and non-recurrent participants, respectively. Recurrence was associated with disturbances in eicosanoid metabolism. Comparison between groups suggest alterations in vitamin B6 (pyridoxine) metabolism, tyrosine metabolism, 3-oxo-10-octadecatrienoate β-oxidation, and alkaloid biosynthesis II. Integrative network analysis revealed enrichment of other metabolic pathways for the recurrent phenotype, including the butanoate metabolism, aspartate and asparagine metabolism, and N-glycan biosynthesis. The metabolites and metabolic pathways predicted in our study suggest potential biomarkers of recurrence and provide insights into targets for antimalarial development against P. vivax.
A deep inverse convolutional neural network-based semantic classification method for land cover remote sensing images
Authors: Wang Ming , She Anqi , Chang Hao , Cheng Feifei , Yang Heming 
Published: March 2024

AbstractThe imbalance of land cover categories is a common problem. Some categories appear less frequently in the image, while others may occupy the vast majority of the proportion. This imbalance can lead the classifier to tend to predict categories with higher frequency of occurrence, while the recognition effect on minority categories is poor. In view of the difficulty of land cover remote sensing image multi-target semantic classification, a semantic classification method of land cover remote sensing image based on depth deconvolution neural network is proposed. In this method, the land cover remote sensing image semantic segmentation algorithm based on depth deconvolution neural network is used to segment the land cover remote sensing image with multi-target semantic segmentation; Four semantic features of color, texture, shape and size in land cover remote sensing image are extracted by using the semantic feature extraction method of remote sensing image based on improved sequential clustering algorithm; The classification and recognition method of remote sensing image semantic features based on random forest algorithm is adopted to classify and identify four semantic feature types of land cover remote sensing image, and realize the semantic classification of land cover remote sensing image. The experimental results show that after this method classifies the multi-target semantic types of land cover remote sensing images, the average values of Dice similarity coefficient and Hausdorff distance are 0.9877 and 0.9911 respectively, which can accurately classify the multi-target semantic types of land cover remote sensing images.
Mutations overlying the miR172 target site of TOE-type genes are prime candidate variants for the double-flower trait in mei
Authors: Gattolin Stefano , Calastri Elisa , Tassone Maria Rosaria , Cirilli Marco 
Published: March 2024

AbstractMutations affecting flower shape in many plants have been favored by human selection, and various fruit trees are also grown for ornamental purposes. Mei (Prunus mume) is a dual purpose tree originated in China well known in the Western world for its generous early blooms, often bearing double flowers. Building on the knowledge of its genomic location, a candidate gene approach was used to identify a 49 bp deletion encompassing the miR172 target site of the euAP2 gene pmTOE (PmuVar_Ch1_3490) as a prime variant linked to flower doubleness. Searching within a large dataset of genome sequencing data from Eastern germplasm collections demonstrated a tight variant-trait association, further confirmed in a panel of commercial and non-commercial varieties available in Italy. Moreover, two SNP mutations in the miR172 target site of pmPET (PmuVar_Ch1_1333) were identified in some double flower accessions. The mei orthologue of PETALOSA genes already found responsible for the phenotype in other plants suggests that independent variants may have been selected throughout mei domestication history.
Application and configuration analysis of electric muck transfer equipment in plateau railway tunnel: a case study in southwest China
Authors: Yang Xiaoxu , Liu Yuming , Liu Kai , Wei Jianying , Hu Guangzhong , Pei Shifan 
Published: March 2024

AbstractThe burgeoning development of railway construction in plateau regions of southwest China necessitates innovative and environmentally sustainable approaches, particularly in the realm of tunnel construction, where the transfer of muck poses significant operational and environmental challenges. This research, pivoting around the application and configuration of electric muck transfer equipment in plateau railway tunnels, seeks to dissect the potentialities and impediments of transitioning from conventional diesel-powered machinery to electric alternatives, with a spotlight on mitigating environmental impacts and enhancing operational efficiency. Through an analytical lens, the study employs a case study methodology, leveraging data and insights from existing electric equipment models and their applications, provided by major manufacturers in China, to weave a comprehensive narrative around the practicalities, specifications, and challenges embedded in the adoption of electric machinery in plateau environments. The findings unveil a nuanced landscape, where the environmental and operational advantages of electric equipment are juxtaposed against a backdrop of technological, financial, and infrastructural hurdles, thereby crafting a complex tapestry of opportunities and challenges. The research further extrapolates policy recommendations and practical guidelines, advocating for a harmonized amalgamation of governmental policies, technological advancements, and strategic planning to navigate through the identified challenges and optimize the integration of electric equipment in tunnel construction practices. Envisaging future research pathways, the study underscores the criticality of perpetuating technological innovations, policy adaptations, and interdisciplinary research to further refine and enhance the application of electric muck transfer equipment in plateau railway tunnel projects, thereby contributing to the broader narrative of sustainable construction practices in challenging terrains.
Comparative metabolomics reveals serum metabolites changes in goats during different developmental stages
Authors: Li Qing , Chao Tianle , Wang Yanyan , Xuan Rong , Guo Yanfei , He Peipei , Zhang Lu , Wang Jianmin 
Published: March 2024

AbstractGoats can provide meat, milk and skins for humans and are livestock with high economic benefits. However, despite their economic significance, the comprehensive analysis of goats’ serum metabolic profile and its intricate alterations throughout their developmental journey remains conspicuously absent. To investigate the stage-specificity and dynamic change characteristics of metabolites during the growth and development of goats, this study compared the alterations in serum hormone levels and serum biochemical markers across different developmental stages of female goats (1, 60, 120 and 180 days old; n = 5). Additionally, a serum untargeted LC–MS metabolomics analysis was conducted. A total of 504 DAMs were identified with age. The results indicated that PE, PC, Lyso-PE, Lyso-PC and FAFHA may play important roles in lipid metabolism in goats after birth. Weighted gene co-expression network analysis (WGCNA) identified two metabolite modules (Turquoise and Yellow) and key metabolites within these modules that were significantly associated with phenotypic features. l-carnitine may be a metabolite related to muscle development in goats. The findings of this study demonstrate notable variations in serum metabolites across distinct developmental phases in goats. Lipids and organic acids play important roles in different developmental stages of goats.
Cellular electrophysiological effects of the citrus flavonoid hesperetin in dog and rabbit cardiac ventricular preparations
Authors: Mohammed Aiman Saleh A. , Mohácsi Gábor , Naveed Muhammad , Prorok János , Jost Norbert , Virág László , Baczkó István , Topal Leila , Varró András 
Published: March 2024

AbstractRecent experimental data shows that hesperetin, a citrus flavonoid, affects potassium channels and can prolong the QTc interval in humans. Therefore, in the present study we investigated the effects of hesperetin on various transmembrane ionic currents and on ventricular action potentials. Transmembrane current measurements and action potential recordings were performed by patch-clamp and the conventional microelectrode techniques in dog and rabbit ventricular preparations. At 10 µM concentration hesperetin did not, however, at 30 µM significantly decreased the amplitude of the IK1, Ito, IKr potassium currents. Hesperetin at 3–30 µM significantly and in a concentration-dependent manner reduced the amplitude of the IKs current. The drug significantly decreased the amplitudes of the INaL and ICaL currents at 30 µM. Hesperetin (10 and 30 µM) did not change the action potential duration in normal preparations, however, in preparations where the repolarization reserve had been previously attenuated by 100 nM dofetilide and 1 µg/ml veratrine, caused a moderate but significant prolongation of repolarization. These results suggest that hesperetin at close to relevant concentrations inhibits the IKs outward potassium current and thereby reduces repolarization reserve. This effect in certain specific situations may prolong the QT interval and consequently may enhance proarrhythmic risk.
Use of the Tubridge flow diverter in the treatment of intracranial aneurysms: a single center experience
Authors: Li Li , Gao Bu-Lang , Wu Qiao-Wei , Shao Qiu-Ji , Wang Zi-Liang , Zhang Kun , Li Tian-Xiao 
Published: March 2024

AbstractTo investigate the safety and effect of Tubridge flow diverter deployment for the treatment of intracranial aneurysms, 85 patients with intracranial aneurysms treated with the Tubridge flow diverter were retrospectively enrolled. The clinical data including the baseline data, aneurysm parameters before and after treatment, and follow-up outcomes were assessed. Among 85 patients, there were 35 (41.2%) males and 50 females (58.8%) aged 17–77 (mean 56.7 ± 11.1) years with 110 aneurysms. Five (5.9%) patients initially presented with subarachnoid hemorrhage from aneurysm rupture. The aneurysm size was 2–30 (mean 8.6) mm, and the aneurysm neck was 2–10.6 (mean 5.7 ± 2.3) mm. Ninety-three Tubridge stents were deployed. Twenty-five (29.4%) patients experienced adjunctive loose coiling. Blood flow was significantly reduced from entering the aneurysm after stent deployment. Periprocedural complications occurred in three (3.5%) patients, including in-stent thrombosis during embolization in one patient (1.2%), conjunctiva edema on the right in one patient (1.2%), and acute multiple cerebral infarctions in one patient (1.2%). Angiographic follow-up was conducted in 67 (78.8%) patients 3–36 (mean 15.3 ± 5.6) months later. In 11 (16.4% or 11/67) patients, blood flow still entered the aneurysm with the O’Kelly-Marotta (OKM) grade B in two (3.0%) patients and grade C in nine (13.4%), whereas complete occlusion (OKM grade D) was achieved in the other 56 (83.6% or 56/67) aneurysms. In-stent stenosis was present in five (7.5%) patients with approximately 25% stenosis in three (4.5%) patients and 50% in two (3.0%). In conclusion, the Tubridge flow diverter can be safely and efficiently applied in the treatment of small and large intracranial aneurysms, with a low periprocedural complication rate, a high occlusion degree, and a low in-stent stenosis rate at follow-up even though large aneurysms may necessitate a longer surgical time and adjunctive coiling.
Variable plate kinematics promotes changes in back-arc deformation regime along the north-eastern Eurasia plate boundary
Authors: Ficini Eleonora , Cuffaro Marco , Doglioni Carlo , Gerya Taras 
Published: March 2024

AbstractThe stretching of the lithosphere leading to back-arc basins formation generally develops behind arc-trench systems and is considered the consequence of slab retreat relative to the upper plate. Here, we examine the deformation regime evolution within the overriding plate due to subduction processes, using thermo-mechanical numerical simulations. We explore the north-eastern Eurasia plate boundary and the mechanisms of subducting Pacific plate since 57 Ma. During this time interval, several extensional basins formed along the Eurasia margin, such as the East China Sea, the Japan Sea, and the Kuril basin. Here, we increased the simulation complexity, with the inclusion of (i) the kinematic variability of the Pacific plate over the geological past with respect to a fixed Eurasia, incorporating time-dependent (i.e., temporally evolving) velocities computed from plate motion reconstructions; (ii) a Low-Velocity Zone within the asthenosphere, and (iii) a horizontal eastward mantle flow. Our results show a crucial role of the mantle flow for the development of lithospheric extension and back-arc basin opening, and a main kinematic control of the subduction trench position, which advances and retreats, into distance intervals in the order of $$\sim$$
∼
100 km, and providing stages of compression and extension in a back-arc basin.
Combination of S100A12/TLR2 signaling molecules and clinical indicators in a new predictive model for IVIG-resistant Kawasaki disease
Authors: Wu Yali , Liu Pan , Zhou Yang , Yang Youjun , Li Shiyu , Yin Wei , Liu Fan , Ding Yan 
Published: March 2024

AbstractAlthough intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) presents with persistent inflammatory stimulation of the blood vessels and an increased risk of coronary artery dilatation. However, the pathogenesis of this disease is unclear, with no established biomarkers to predict its occurrence. This study intends to explore the utility of S100A12/TLR2-related signaling molecules and clinical indicators in the predictive modeling of IVIG-resistant KD. The subjects were classified according to IVIG treatment response: 206 patients in an IVIG-sensitive KD group and 49 in an IVIG-resistant KD group. Real-time PCR was used to measure the expression of S100A12, TLR2, MYD88, and NF-κB in peripheral blood mononuclear cells of patients, while collecting demographic characteristics, clinical manifestations, and laboratory test results of KD children. Multi-factor binary logistic regression analysis identified procalcitonin (PCT) level (≥ 0.845 ng/mL), Na level (≤ 136.55 mmol/L), and the relative expression level of S100A12 (≥ 10.224) as independent risk factors for IVIG-resistant KD and developed a new scoring model with good predictive ability to predict the occurrence of IVIG-resistant KD.