bluuebunny/crossref_metadata_2025_split huggingface dataset:
5‐methyl‐cytidine as an inhibitor of spontaneous cancer in mice
Authors: Strong Leonell C. , Matsunaga Henry 
Published: February 2007

AbstractThree nucleosides, found in a specially prepared liver emulsion (Mittelman), are inhibitors of the growth of spontaneous tumors of mammary gland origin in mice. The present data demonstrate that 5 methyl cytidine when used in the same molar concentration (0.02) as it is found in the liver emulsion is a powerful inhibitor of spontaneous adenocarcinomata irrespective of age of the cancer proband. More inhibition is obtained in mice between 9 and 12 months of age than between 5 and 8 months. The later appearing tumors (at 9–12 months) grow faster in the controls than those which develop between 5 and 8 months of age. It is reasonable to conclude that 5 methly cytidine has a more inhibitory action on fast growing tumors than upon slower growing ones. However, this inhibitory difference may be mediated somehow or other by a “transmissible entity” or by some other secondary mechanism associated with the aging process. The present series of experiments suggests the possibility that by the simultaneous or tandem use of several nucleosides a broader effect of an inhibitory action on cancer in mice may be forthcoming.
An analysis of cylindroma of the head and neck
Authors: Steinhoff Neil G. , Harris Hugh S. , Hori Jose 
Published: February 2007

AbstractThere were 30 cases of cylindroma at Ellis Fischel State Cancer Hospital from 1940 to 1969. Of these 30 cases, 22 were seen initially at Ellis Fischel. Fourteen patients died of cylindroma; the average survival from diagnosis to death was 66 months. Reappearance occurred in 20 of the 30 cases, with the interval between the first reappearance of tumore being 32 months. Tumor was located in the major salivary gland in 9 cases, minor salivary gland in 8 cases, and paranasal sinuses in 3 cases. Tumor frequently invaded bone, became fixed to surrounding structures, and not infrequently metastasized widely. Treatment consisted of surgery and/or radiation therapy. Of the 22 cases seen initially at Ellis Fischel, 16 were pure cylindromas, 2 were mixed with mucoepidermoid, 1 was mixed with adenocarcinoma, and 3 were mixed with epidermoid carcinoma. Four patients were cured of their cylindormas, as determined by survival at 10 or more years. All these cures were arrived at through surgical extirpation of the tumor. Radiotherapy and infusion chemotherapy gave good palliation but no cures. Adequacy of margin around the tumor was the single most important factor in cure. It is found that biopsy of the tumor did not alter survival. Patients with parotid tumors did much better than tumors located in other areas. Fixation of the tumor mass did not alter survival and nodal involvement was an ominous sign. The study indicated the way to improve survival was by resecting the tumor re‐resecting until all margins are adequate.
The role of irradiation in breast carcinoma
Authors: Kagan A. Robert , Nussbaum Herman , Reddi P. R. 
Published: February 2007

AbstractThe literature on the role of irradiation in breast carcinoma was reviewed in detail. Routine postoperative irradiation of breast cancer has not altered the prognosis of carcinoma of the breast. Various classifications of breast cancer, including AJC, UICC, Haagensen, and M. D. Anderson, are discussed in detail and differences outlined in Table II. The clinical stages of cancer of the breast are outlined in Table III. Stage I is essentially operable; Stage III is essentially inoperable. It is in Stage II that preoperative irradiation should be considered, although at present untested. The future role of irradiation in cancer of the breast is in the preoperative treatment of operable Stage II lesions, and in the early lesion which, perhaps, can be treated with preservation of the breast. Small doses of irradiation for breast cancer are not recommended.
Erythropoietic response of the neonatal rat to hypertransfusion and erythropoietin (Ep)
Authors: Cantor Linda N. , Gordon Albert S. 
Published: February 2007

AbstractA sustained state of plethora cannot be induced in neonatal rats by intraperitoneal injections of RBC. On the other hand, erythropoiesis is markedly and rapidly suppressed by intra‐cardiac injections of RBC. The data suggest that administration of Ep to such animals results in a two‐fold action: an early release of reticulocytes followed by a true stimulation of erythropoiesis.
Effect of syngeneic tumor tRNA on MOPC 315 myeloma in BALB/cCR mouse
Authors: Brugarolas A. , Takita H. , Elias E. G. , Mittelman A. , Luch J. 
Published: February 2007

AbstractExperimental tumor immunotherapy using syngeneic histiocytes and tumor tRNA was carried out on MOPC 315 transplantable myeloma of BALB/cCR mouse. Syngeneic histiocyte‐tumor tRNA complex demonstrated strong cytotoxic effects against MOPC 315 cells in vitro. Administration of this complex resulted in prolongation of survival in the tumor‐bearing mice. Injection of syngeneic tumor tRNA alone apparently caused tumor growth enhancement.
Experimental bladder carcinogenesis — using cigarette smoke condensate in the rat bladder
Authors: Wagle Datta G. , Lee Jungeon 
Published: February 2007

AbstractThe human and experimental evidence with carcinogenic polynuclear aromatic hydrocarbons and other active products in the genesis of bladder cancer nevertheless demonstrates the urgent need for an epidemiologic analysis of worker groups occupationally exposed to such chemicals. Sections of the general population may also inhale or ingest such chemicals with cigarette smoking or the drinking water polluted with industrial effluents. The present studies noted bladder tumor induction after cigarette smoke condensate exposure. However, the incidence was not great and suggests that time of exposure and other as yet unidentified tumor promoting co‐factors were not present.
Effect of halothane and cyclopropane anesthesia on the pha response of lymphocytes
Authors: Lo Gerfo P. , Hsu C. C. S. 
Published: February 2007

AbstractHalothane and Cyclopropane anesthetics had little or no effect on the immune competence of lymphocytes as measured by their response to PHA. These results again demonstrate the rapid irreversibility of the cellular effects of these anesthetics and suggest that the inhibition of the immune response seen in post operative patients is related to serum factors yet undermined.
Mesenchymoma of the mandible
Authors: Muldoon C. J. 
Published: February 2007

AbstractAn unusual mandibular tumor described by the eminent bone tumor specialist Dr. L. Lichenstein as a mesenchymoma is described in a seven year old African girl. Successful resection of the neoplasm and the eventual reconstruction of the defect six months later are described. Shortly the patient will have the splint removed and be fitted with a dental prosthesis for functional and aesthetic purposes.
Reimplantation of autogenous parathyroid tissue: An experimental study
Authors: Matsuura Hidehiro , Sako Kumao , Marchetta Frank C. 
Published: February 2007

AbstractFour different techniques of parathyroid gland reimplantation into muscle were studied in 38 dogs following total parathyroidectomy. The types of autotransplants were whole gland, minced glandular tissue, thin slices 0.3 mm or less, and thick slices 0.4 mm to 0.5 mm. The animals were followed for four months. Parathyroid function was evaluated by serum calcium and phosphorus determinations. Graft sites were extirpated two months after re‐implantation and studied histologically. The thin slice technique was found to be most successful of the four techniques studied.
Skin test in bronchogenic carcinoma: I. Correlation of the immunological status and the extent of the disease
Authors: Takita Hiroshi , Brugarolas Antonio 
Published: February 2007

AbstractDelayed hypersensitivity reaction of 58 consecutive cases of bronchogenic carcinoma was studied by skin tests. None of the patients with excellent skin reaction was found to have hematogenous metastasis. All patients with negative skin reaction had hematogenous metastasis and all but two such patients died within 2 months. Patients with localized tumors or lymph node metastases appear to maintain competent delayed hypersensitivity reaction and a move toward more aggressive approaches in treating the patients in this group is proposed. It is suggested that skin testing in bronchogenic carcinoma could provide useful information of the extent of the tumor and immunological status of the patients, and should, therefore, be included in routine work‐ups.
Cervical neuromas following extensive maxillofacial surgery
Authors: Graham William P. 
Published: February 2007

AbstractAmputated branches of the cervical plexus may develop neuromas within the area of a radical neck dissection. At times these are palpable and are thought to be recurrent tumor. The distinction between recurrent tumor and neuroma cannot be made easily. Many patients who have extensive maxillofacial surgery have discomfort or neuromas within the operated area postoperatively. Five patients have been found to have palpable neuromas within their cervical operative field, but 84% (42/50) had painful neurological symptoms or unusually sensitive areas within the area of previous surgery. Only a third of this latter group had recurrent tumor.
Immunologic studies in lymphoma and leukemia, and exploration of antitumor immunotherapy
Authors: Sokal Joseph E. 
Published: February 2007

AbstractProspective studies, conducted over a period of years, have demonstrated that survival with malignant lymphoma or chronic leukemia correlates with the status of patients' cellular immune reactivity. BCG vaccination can stimulate cellular immune responses of patients with well‐controlled neoplastic disease, and repeated vaccination with BCG‐cell mixtures induces both delayed hypersensitivity to antigens of the vaccine mixtures and general stimulation of this class of immune responses. An exploratory trial of immunologic stimulation in chronic myeloctyic leukemia has yielded unequivocally favorable results, and it appears that immunotherapy may contribute significantly to the control of several types of human neoplastic disease.
Current therapy approaches of the division of cancer treatment with emphasis on pancreatic carcinoma
Authors: Carter Stephen K. 
Published: February 2007

AbstractThis paper outlines the background of the National Cancer Institute clinical drug testing program and introduces current concepts for integrating this program into disease‐oriented combined modality approaches to the primary treatment of cancer. The combined modality thrust involves chemotherapy, surgery, and/or radiotherapy and is illustrated by treatment protocols for adenocarcinoma of the pancreas developed by the Gastrointestinal Tumor Study Group organized by the NCI Division of Cancer Treatment. One study seeks a controlled evaluation of postoperative treatment with 5‐Fluorouracil and supervoltage radiation for improving disease‐free interval and survival in ductal, acinar, and undifferentiated variety of pancreatic adenocarcinoma. The other study compares the effectiveness of high‐dose radiation alone or with 5‐FU and medium‐dose radiation plus 5‐FU in localized but unresectable disease. A number of other combined modality approaches planned or in progress within the National Cancer Institute are briefly discussed.
Complete regression of metastatic tumors of the adult with antimitotic treatment
Authors: Pommatau E. , Brunat M. , Mayer H. , Dargent M. 
Published: February 2007

AbstractWe have presented 7 patients in whom metastatic carcinoma regressed by chemotherapy alone. They are well without evidence of disease for 5 to 10 years. The patients include 4 embryonal carcinoma of the testis, 1 uterine chorioepithelioma, 1 prostatic sarcoma, and 1 trabeculo‐follicular epithelioma of the thyroid. They received 1 or more courses of chemotherapy (trenimon or nitromin alone, or triple association actinomycin D, methotrexate, and cytoxan). We cannot explain why these are apparently cured and why others, treated with the same drugs, had no regression at all. No immunological studies were done.
Colorectal carcinoma in the first twenty‐five years of life
Authors: Pissiotis C. A. , Gulesserian H. P. , Condon R. E. 
Published: February 2007

AbstractA review of 17 patients under 25 years of age suffering adenocarcinoma of the colon or rectum indicates that the disease is characterized by sudden onset, short duration of symptoms, early dissemination and a high grade of malignancy. The ultimate prognosis and survival is poor.
Adenoacanthoma of the appendix
Authors: Schulte W. J. , Pintar K. , Schmahl T. 
Published: February 2007

AbstractA case report is made of a 91 year old veteran who presented with a small bowel obstruction at the ileocecal valve secondary to an adenoacanthoma at the base of the appendix. The tumor was removed with the right colon and the patient has done well to the present (one year follow‐up).A short review of the theory of the origin of the squamous component is presented. There is a brief discussion of the clinical material that suggests these tumors have a response similar to an adenocarcinoma of the colon and should be treated as such.
The intercostobrachial nerve in radical mastectomy
Authors: Assa Jacob 
Published: February 2007

AbstractPreservation of the intercostobrachial nerves during radical mastectomy for cancer of the breast was found to be rewarding. Of 46 mastectomies, 13 so treated were free of throbbing and paraesthesia sensations, while the other 33 had mild to severe complaint. The operative technique is described.
Carcinoembryonic‐like antigen in the urine of patients with carcinoma of the bladder and normal controls
Authors: Guinan Patrick , Ablin Richard J. , Sadoughi Nader , Bush Irving M. 
Published: February 2007

AbstractThe urine and plasma of 16 patients with carcinoma of the bladder, and 27 normal individudls were studied for the presence of carcinoembryonic antigen (CEA). An attempt was made to determine whether urine CEA‐like antigens are filtered by the kidney or shed directly by the bladder tumor itself. There were elevated levels of CEA in the plasma of patients with bladder tumors. The urine of patients with bladder carcinoma had significantly higher levels of CEA‐like antigen than the urine of normal individuals. These same bladder tumor patients did not have a positive correlation between their plasma CEA and the urine CEA‐like antigen levels. It appears from these findings that urinary carcinoembryonic‐like antigen is shed directly into the urine and not filtered by the kidneys.
The problem stoma
Authors: Helsper James T. 
Published: February 2007

AbstractA new method of correcting a tracheal stoma stricture is presented. It utilizes silastic tubes of rubber‐like properties. Increasing sizes are worn to dilate gradually the strictured stoma. The stoma is then maintained by the largest “stomal button” indefinitely. There was practically no irritation or inflammation in a series of 35 patients with problem stomas, and in no case was there failure to correct the microstomia.
Restoration of immunologic memory in the tumor‐bearing mouse
Authors: Humphrey Loren J. , Boehm O. Robert , Fetter David 
Published: February 2007

AbstractUsing C3H/HeHa mice and a transplanted methylcholanthrene sarcoma induced in this strain, the effect of simple and radical amputation of the tumor‐bearing leg on tumor immunity was evaluated. Radical amputation of the tumor‐bearing leg removed the protective effect upon subsequent tumor challenge while immunity was present in mice submitted to only simple amputation of the tumor‐bearing leg. However, radical amputation of the contralateral normal leg resulted in failure to demonstrate protection to subsequent challenge. These data suggest that severe stress is the cause of lack of demonstrable immunity in these mice.Restoration of immunity was attempted by injecting a tumor vaccine after radical amputation. When injected immediately after the operative stress, no immunity to tumor was seen. On the other hand, if the vaccine was injected 12 days after operation, protection once again was demonstrated.
Intravenous hyperalimentation for the onco‐surgical patient
Authors: Assa Jacob , Schramek Alfred , Barzilai Ami , Weisz George M. 
Published: February 2007

AbstractThe present paper deals with caloric and protein supply for the onco‐surgical patient. The technique of total intravenous hyperalimentation, described by Dudrick, was used in 85 patients in our surgical service. Among them were several onco‐surgical cases in which a normal life was expected following the acute hypermetabolic state.The technique of preparation and administration of the I.V.H. is presented. Two illustrative cases are described in detail and the rationale for the use in onco‐surgical cases is discussed.
Why do basal cell carcinomas recur (or not recur) following treatment?
Authors: Jackson Robert 
Published: February 2007

AbstractThere seem to be two types of recurrences of basal cell carcinoma ‐ those due to regrowth of residual tumor (residual tumor recurrence) and those due to growth of a new independent tumor (new tumor recurrence). Twelve examples of residual tumor recurrence and three of new tumor recurrence are briefly presented. Also two examples of nonrecurrence of basal cell carcinoma following incomplete surgical removal are outlined. False negative and false positive pathological reports occasionally occur, and some basal cell carcinomas may show residual tumor recurrence years after the primary treatment.These findings suggest that there is more to the treatment of certain basal cell carcinomas than wide local excision or local destruction.
The surgical management of cancers of the cheek
Authors: Bakamjian Vahram Y. 
Published: February 2007

AbstractDespite advances in radiotherapy, chemotherapy, and immunotherapy, radical surgery still remains by far the single most effective means for controlling advanced cancers of the cheek, including their local extensions and regional metastases into lymph nodes. The destructive and incapacitating nature of radical extirpative management, however, is prohibitive unless they can be neutralized by the judicious application of reconstructive techniques for effective, safe, and expeditious rehabilitation.
Prosthetic rehabilitation of the head and neck cancer patient
Authors: Schaaf Norman G. , Carl William 
Published: February 2007

AbstractThe interested general dentist does have an opportunity at times to provide prosthetic rehabilitation services for the head and neck cancer patient who arises in his practice. Also if the dentist is associated with a hospital that does head and neck cancer surgery, he will find that his services will be requested more frequently. Although the scope of maxillofacial prosthetics encompasses many complicated types of prostheses for the head and neck area, the general dentist using equipment and supplies readily available in his office can prepare many kinds of simple oral prostheses. These prostheses can return a patient who is unable to speak, eat, or swallow appropriately back to full function. In addition to providing routine general dental care for these patients it is the responsibility of the dentist to provide these prosthetic rehabilitative prostheses to the head and neck cancer patient in his practice or see to it that the patient is referred to a nearby maxillofacial prosthetic center.
Oral neoplasia: Its significance and behavior
Authors: Natiella Joseph R. 
Published: February 2007

AbstractAn understanding of the behavior of oral malignancy is necessary to insure early detection of this disease by the dentist. Alterations in oral mucosa such as keratotic plaque, erythematous granular erosions, and foci of pigmentation'often demonstrate a microscopic spectrum of epithelial atypia. Of primary concern to the dentist is the fact that carcinoma may mimic periodontal disease and often occurs in inaccessible areas of the mouth such as the base of the tongue. Metastasis occurs more often in lesions over 2 cm in size and studies suggest that a large percentage of patients have positive nodes at the time of initial examination. The dentist's approach to oral malignancy must include adequate examination, proper use of biopsy and cytology techniques, and expeditious referral.
Recurrence patterns in squamous cell carcinoma of the oral cavity, pharynx, and larynx
Authors: Gilbert Harvey , Kagan A. Robert 
Published: February 2007

AbstractThe purpose of this review is to document patterns of failure with the existing modalities of therapy in carcinomas of the upper aerodigestive tract. Most attention is given to regional failure, which is separately divided into primary site and metastatic cervical adenopathy. Survival, stage of the lesion, conversion of the clinically negative neck, and salvage of treatment failure is discussed.Either with surgery, radiations or combination, the commonest regional failure still remains in the primary site.Of additional importance is the unexpectedly poor salvage rate of previous treatment failures (16%).Histologically involved lymph nodes appears to portend a poor prognosis with a high failure rate seen not only in the neck but also in the primary site with or without distant metastases. Nodal involvement indicates mostly the aggressive biological nature of the primary lesion. The most common failing by authors, whose reports had to be excluded from this review, was a preoccupation with survival statistics and a general inattention paid to documenting the specific failure site.
Glycogen metabolism in epidermal wound healing
Authors: Hoopes John E. , Im Michael J. C. 
Published: February 2007

AbstractEnzymatic cycling methods have been applied to the quantitative measurement of glycogen content during wound healing and utilized for an estimation of the contribution of glycogen to metabolism in association with ischemia. Tissue glycogen accumulated in regenerating epithelium during the fnst 7 days of wound healing. Increasing gradients of glycogen concentration were demonstrated from the marginal epithelium to the distal portions of the migrating epithelium. Glycogen content was increased to 13 times normal in the distal portion of migrating epithelium on day 3 post‐injury. A study of ischemia revealed that the accumulated glycogen appeared to constitute an emergency ration for repairing epithelium and contributed considerably to energy production.
CEA Levels and prognosis in colon carcinoma
Authors: Bivins B. A. , Boyd Carl R. , Meeker William R. , Griffen Ward O. 
Published: February 2007

AbstractThis is a report of the post‐operative follow‐up of CEA titers in 16 patients with carcinoma of the colon and rectum. Our results differ from those previously reported in several respects. First, we rarely observed the return of elevated pre‐operative CEA levels to normal within 14 days of curative resection. Second, we have found that CEA levels may be elevated for as long as 3 months in patients clinically free of disease before returning to normal. Third, some patients may maintain elevated CEA titers for 6 months following potentially curative resection without clinical evidence of disease. Finally, we have advanced a tentative hypothesis based on immunologic suppression of residual tumor growth to explain the discrepancy between our findings and those reported by others. These data suggest that failure to detect an early decline in CEA levels to normal may not imply a poor prognosis.