bluuebunny/crossref_metadata_2025_split huggingface dataset:
Herpetiform Protothecosis
Authors: Goidstein Glenn D. , Bhatia Paramjit , Kalivas James 
Published: May 2007

A 61‐yerir‐old white woman with myasthenia gravis presented at the University of Kansas Medical Center with a 2‐month history of painful, grouped, blister‐like lesions on an erythematous base localized to the presternal area (Fig, 1). The patient previously had been treated with a 2% topical erythromycin solution, triamcinolone cream 0.1%, 0.25% menlhol, and camphor in Acid Mantle Creme. There was no history of previ(His trauma, infection, or foreign travel. The patient also denied the use of well water for bathing.The patient's past history included treatment with clotrimazole solution for onycholysis, secondary to Candida. The family history was unremarkable for blistering disorders.Laboratory evaluation revealed negative pemphigus and pemphigoid antibody titers. Viral culture ot the lesions showed no growth. Inoculation of a skin biopsy on Sabour‐aud's agar was negative.The skin biopsy ot an intact lesion was characterized by hyperkeratosis, focal parakeratosis, and pseudoepitheliomatous hyperplasia. A dense, chronic, inflammatory cell infiltrate of lymphocytes, histiocytes, and plasma cells was present in the upper and middle dermis, Scattered in the infiltrate were numerous giant ceils and ill‐defined granulomas without ne‐crosis (Fig, 2), Numerous algal organisms were present in the upper dermis and in the hypcrkeratotic layer of the epider‐mis. The organisms were thick‐walled, oval, or spheric al. and measured from 3 to 15 μm in diameter. Internal spore for‐mation and a distinct moriila paftern was present, consistent with prototbecosis (Fig. 3), No vesicles were present histo‐logically. The organism stained intensely with periodic acid‐Schiff and Comori's methenamine silver stains (Fig, 4), Direct immunofluorescence staining was negative for complement or immunoglobulin deposition.Treatment with topical polymyxin B, bacitracin, and neomycin four times daily for 1 month was followed by resolution of all lesions.
Chromoblastomycosis Can Mimic Keratoacanthoma
Authors: Wiss Karen , Mcneely M. Carol , Solomon Alvin R. 
Published: May 2007

A 59‐year‐old white man presented to the Dermatology Clinic at the University of Texas Medical Branch with ti verrucous nodule on the right forearm. The patient was a retired woodworker. He had polytiiyositis with pulmonary fibrosis for 5 years. Prednisone and mcthotrexate were required to control his disease.A crusted verrucous nodule 2.5 by 2.5 cm in diameter with adjacent similar‐sized atrophic scars were present on the extensor surface of the right forearm (Fig. 1). This particular nodule had been present for 2 years, and its growth was characterized by a rapid onset with progressive enlargement and intermittent partial regression. The adjacent scars represented similar lesions that had spontaneously regressed. Although the patient had not worked since his illness began, he continued to actively pursue woodworking as a hobby.Histologic sections of the excised nodule revealed massive pseudoepitheliomatous hyperplasia with prominent hyper‐keratosis. Intraepidermal microabscesses were numerous and a suppurative neutropbilic infiltrate with scattered foreign body type multinucleated giant cells was present in the dermis (Fig. 2). At higher magnification, numerous light brown yeasts, approximately 10 μm in diameter (Fig. 3) were noted both within tbe giant cells and free within the dermis. Chains of yeast cells were common. These histologic findings are diagnostic of chromoblastomycosis.3
Thesis Reviews
Authors: MAIBACH HOWARD I. 
Published: May 2007

Books reviewed in this article: AETIOLOGICAL STUDIES OF PSORIASIS: A SURVEY. Flemming Brandrup A CLINICAL AND IMMUNOLOGICAL STUDY OF EGG ALLERGY. Tor Langeland IMMUNOLOGICAL STUDIES IN PATIENTS WITH NICKEL, COBALT, AND CHROMIUM SENSITIVITY. Nabil Al‐Tawil PEMPHIGUS. Jarkko Hietanen HAND ECZEMA AND LONC‐TERM PROGNOSIS IN ATOPIC DERMATITIS. Ingela Rystedt
5‐Methoxy Psoralen, Etretinate, and UVA for Psoriasis
Authors: Lane‐Brown Malcolm 
Published: May 2007

ABSTRACTThis first Australasian randomized trial of 5‐methnxy psoralen (5‐MOP) PUVA for psoriasis shows, conclusively, less acute side effects than 8‐MOP PUVA. Daily addition of oral etretinate to the PUVA regimen (Re‐PUVA) produces a valuable reduction in total joules and more so with 5‐MOP than with 8‐MOP. The clearing phase with 5‐MOP Re‐PUVA is quicker than with 8‐MOP Re‐PU VA in skin types 1, 2, and 3 (most Anglo‐Saxon‐Celtic Australians). Doses, when adapted to total body surface rather than mg/kg, allow superior control of therapy. Emollient creams, tar gels, non‐steroidal scalp applications, etc. allow more patient comfort.
Melasma in Men
Authors: Vázquez Miguel , Maldonado Héctor , Benmamán Coty , Sanchez Jorge L. 
Published: May 2007

ABSTRACT: Melasma is characterized by a facial hypermelanosis of light to dark brown color, being more common in women of Hispanic origin, in this study, 27 men with melasma were evaluated clinically and histologically to compare their features with those of previous studies. Three patterns of localization were recognized, namely, centrofacial, malar, and mandibular. On the basis of Wood's light examination, an epidermal, a dermal, and a mixed type were identified. Epidermal hyperpigmentation only and epidermal and dermal hyperpigmentation were found in histologic analysis of the cases. Significant etiologic factors included exposure to sunlight in 66.6% as well as a familial predisposition in 70.4% of the cases.This study demonstrated that melasma in men shares the same clinicohistologic characteristics as in women, but hormonal factors do not seem to play major significant role.
Primary Localized Cutaneous Lichen Amyloidosus of the vulva
Authors: Gorodeski I.G. , Cordoba M. , Shapira A. , Bahary C. M. 
Published: May 2007

A woman, age 72, gravida 5, para 5, was hospitalized for a vulvar biopsy. Her past history revealed a generally healthy woman, menopausal from the age of 53, who had a vaginal hysterectomy and repair at the age of 68 because of genital prolapse. One year before her present admission, the woman started complaining of pruritus vulvae, which progressively worsened. On admission, general physical examination revealed no outstanding pathologic findings; gynecologic examination revealed advanced atrophy of the external genitalia and the vaginal wall. The clitoris and the small labia were atrophic, scarred, and only slightly elevated off the surface (Fig. 1). The vulvar skin was shiny with scattered white patches that were not elevated and had no shiny borders. The rectal examination was normal, and inguinal lymph nodes were not palpable. Laboratory tests revealed the following: sedimentation rate 15/26, hemoglobin 15 gidl, WBC 6400/mm3 (with normal differential count), thrombocytes 150,000/mm‐3, serum alkaline phosphatase 100 mu/ml (normal 30–85), uric acid 7 mg/dl (upper normal value 6.4). Serum electrolytes, blood urea nitrogen, glucose, cholesterol, creatinine, total proteins, albumin, glutamic ox‐aloacetic transaminase, lactic dehydrogenase, creatine phosphokinase, diastase, urine analysis, chest x‐ray, and electrocardiogram were normal. Vulvar biopsy was per‐formed under general anesthesia. Histologic examination of vulvar skin was as follows: the epidermis was hyperkeratotic with granulosis and acanthosis (Fig. 2). There were enlarged blood vessels in the dermis with thickened and hyalinized walls and foci of infiltration of round cells. The papillaris and reticularis revealed amorphic areas that stained positively with Congo red (Fig. 3). The histologic diagnosis was amy‐loidosis of the vulvar skin.After the histologic report was received, further investiga‐tions were done, as follows: urine Bence Jones protein was negative, serum protein electrophoresis and immunoelec‐trophoresis were normal, and no free light chains were found in the plasma. Serum antinuclear factor and tubercu‐lin skin test were negative. The patient refused to undergo rectal biopsy. She was initially treated with local application of testosterone ointment. After 2 months of treatment, the itching worsened and we started with applications of iso‐conazole nitrate and diflucortolone valerate. This treatment was followed by prompt relief of symptoms, although the gross appearance of the lesions had not changed. One year later, the patient feels well and refuses repeat biopsy.
Urticarial Papular and Plaque Eruptions A Noneczematous Manifestation of Allergic Contact Dermatitis
Authors: M.Med. C. L Goh 
Published: May 2007

ABSTRACT:A noneczematous eruption associated with allergic contact dermatitis is described. Five patients had disseminated erythematous urticarial papular and plaque eruptions secondary to contact allergy to two substances (four to proflavine and one to a permanent waving lotion). The eruption appeared to be similar to the previously described “erythema multiforme‐like eruption” associated with allergic contact dermatitis. A review of the previous report indicated that the eruptions currently being reported do not have the typical clinical and histologic features of erythema multiforme. The term “urticarial papular and plaque eruption of contact allergy” is suggested to describe the eruption. The exact mechanism of the eruption remained speculative.
Morphea After Bromocriptine Therapy
Authors: Leshin Barry , Piette Warren W. , Caplan Richard M. 
Published: May 2007

ABSTRACT:A 57‐year‐old man developed morphea while taking bromocriptine. This drug is a semisynthetic ergot alkaloid, one of a class of drugs that is associated with fibrotic disorders. Other agents known for such association are serotonin (5‐hydroxytryptamine) and p‐adrenergic blockers. A common pathogenesis to link these agents to fibrosis remains uncertain.
Epidemiologic Characteristics of Scabies in the Israel Defense Force
Authors: Kimchi Nimrod , Green Manfred S. , Stone David 
Published: May 2007

ABSTRACT:Scabies is not a notifiable disease in most countries. As a result the data on its epidemiologic characteristics are limited. In the Israel Defense Force, compulsory reporting of individual cases has been required for years, and in this study the epidemiology of the disease is examined for the years 1968–1988. A moderate epidemic occurred between 1969 and 1973, and was followed by a return to the previous low incidence. In 1982 a massive outbreak began, and peaked from 1985–1986. From 1987 to 1988, the incidence of infestation has markedly declined. A seasonal pattern of morbidity was evident during epidemic periods only; maximum incidence occurred during the winter months. These data are compared with those described in other countries and provide a more complete picture of the epidemiology of scabies based on individually reported cases.
Double‐Blind Comparison of Itraconazole with Griseofulvin in the Treatment of Tinea Corporis and Tinea Cruris
Authors: Bourlond A. , Lachapelle J. M. , Aussems J. , Boyden B. , Campaert H. , Conincx S. , Decroix J. , Geeraerts Ch. , Ghekiere L. , Porters J. , Speelman G. , Tennstedt D. , Kint T. , Vandaele R. , Van Den Haute V. , Van Lint L. , Willocx D. 
Published: May 2007

ABSTRACTSeventy‐eight patients with tinea corporis or tinea cruris participated in a double‐blind study with either 100 mg itraconazole or 500 mg ultramicromized griseofulvin for 15 consicutive days. Clinical outcome was significantly in favor of itraconazole at completion of treatment (72% responce rate vs. 51%) and at the follow‐up visit(91% response vs. 64%). The most important difference berween both treatment was the mycologic outcome, for which itraconazole showed a cure rate oc 87% compared to 57% for griseofulvin 2 weeks after comparison of therapy. It is suggested that 100 mg of itraconazole orally daily is significantly more effective than 500 mg of griseofulvin once daily for 15 days in the treatment of glabrous skin infections. Both drugs were well tolerated.
Basal Cell and Squamous Cell Carcinoma of the Skin in Finland
Authors: Karjalainen Sakari , Salo Hannu , Teppo Lyly 
Published: May 2007

ABSTRACTLong‐term survival of patients with basal cell (BCC) and squamous cell carcinoma (SCC) of the skin and site distribution of the lesions were studied using ample nationwide cancer registry data. The material consisted of 23,975 patients with BCC and 2,927 patients with SCC diagnosed in Finland from 1967 to 1981. The proportion of patients with lesions in the head and neck region was 77.5% in men and 81.4% in women for BCC and, 75.7% in men and 75.8% in women for SCC. The 5‐ and 10‐year relative survival rates (RSRs) of patients with BCC were very close to 100%. The 5‐year RSR of patients with SCC diagnosed from 1974 to 1981 was 87.7% in men and 84.0% in women. In patients with SCC the worst prognosis was for lesions of the scalp and neck in men (80.2%) and for those of the ears in women (73.2%).
Malignant Angioendotheliomatosis
Authors: Drobacheff C. , Blanc D. , Zultak M. , Humbert P. , Carbillet J. P. , Dupond J. L. , Laurent R. 
Published: May 2007

ABSTRACTA 70‐year‐old woman with chronic edema of the lower limbs was diagnosed as having a “malignant angioendotheliomatosis,” because histologic examination showed a strict intravascular location of a malignant proliferation. Immunochemical studies actually disclosed the lymphomatous origin of malignant cells. The recent literature regarding the nosology of this rare condition is reviewed.
Plasminogen Activators and Antiplasmin Activity in Atopic Dermatitis
Authors: Lotti T. , Battini M. L. , Brunetti L. , Fabbri P. , Panconesi E. 
Published: May 2007

ABSTRACTCutaneous deposits of fibrinogen, fibrinolytic activity in lesional skin, plasmatic fibrinolytic activity, and anti‐plasmin activity (α2 macroglobulin, αl antitrypsin and antithrombin III) were evaluated in a group of ten patients with atopic dermatitis and in a sex‐ and age‐matched control group. Plasma fibrinolytic activity was increased in the acute phase of the disease (p < 0.05). The levels of circulating antiplasmins appeared similar in the patients and the control group. Cutaneous fibrinolytic activity was increased in the acute phase of the disease in 5 of 5 cases, suggesting a role of the fibrinolytic system in the amplification of the inflammatory phenomenon in that phase of the disease. In the chronic lichenified phase, CFA was decreased in 3 of 5 cases leading to an excessive deposit of fibrin in the skin. This could be correlated with the abnormal vascular response (blanching phenomenon). On the basis of these data, the therapeutic use of the antifibrinolytic agents only seems rational in the acute phase of the disease.
Keratotic Melanocytic Nevus
Authors: Gurbuz Oya , Hurwitz Robert M. 
Published: May 2007

Abstract:Thirty‐five percent of 363 melanocytic nevi were found to have a keratotic epithelial architectural pattern that was mostly infundibular and not previously emphasized. Keratotic melanocytic nevi were commonly from the trunk of women, and most were associated with an intradermal melanocytic nevus. The clinical and histopathologic features as well as a review of the literature of these keratotic melanocytic nevi are presented.
The Role of Cutaneous Sensory Nerves in the Maintenance of Psoriasis
Authors: Farber Eugene M. , Lanigan Sean W. , Boer Jurr 
Published: May 2007

ABSTRACT:This is a case report of two patients with chronic plaque psoriasis in whom cutaneous nerve damage resulted in clearance of the disease at that site. In both patients reappearance of the psoriasis occurred with recovery of cutaneous sensation. The role of cutaneous sensation in the maintenance of skin disorders and, in particular, the role of neuro‐peptides in the pathogenesis of psoriasis are discussed.
Balanitis of Zoon
Authors: Nishimura Masayuki , Matsuda Tetsuo , Muto Masahiko , Hori Yoshiaki 
Published: May 2007

ABSTRACT:A patient with an eruption of clinical and histologic features typical of plasma cell orificial mucositis of the glans penis is reported. Immunohistologically, IgE and IgG are found to be major immunoglobulin classes in the plasma cellular infiltrate. Although specific allergen has not been identified yet, the present findings suggest that this condition is not‘a nonspecific inflammatory response but is related to immediate hypersensitivity.
Relationship Between Capillary and Muscle Damage in Dermatomyositis
Authors: Casademont J. , Grau J. M. , Estruch R. , Pedro‐Botet J. C. , Urbano‐Márquez A. 
Published: May 2007

ABSTRACT:To assess the pathogenetic importance of capillary damage and its relationship with degenerating muscle fibers in dermatomyositis (DM), an electron microscope study of eight muscle biopsy specimens (adult and juvenile forms) and seven muscle specimens from patients with other neuro‐muscular diseases was conducted. There was a 49% reduction of capillaries in the muscle specimens of DM patients. Capillary damage also was more frequent in the DM group than in control group (p<0.001). We found a striking relation between capillary and muscle damage in the DM group (p<0.002) but not in the control group. The diagnostic value of undulating tubules within endothelial cells is also discussed.
MICROBIOLOGY OF SECONDARILY INFECTED DIAPER DERMATITIS
Authors: BROOK ITZHAK 
Published: May 2007

AbstractSpecimens obtained from 67 infants with secondarily infected diaper dermatitis were cultured for aerobic and anaerobic bacteria. Bacteria growth was obtained in 58. Aerobic facultative bacteria or Candida sp. only were present in 28 patients (48%), anaerobic bacteria only in 11 (19%), and mixed anaerobic with aerobic, facultative, or yeast flora was present in 19 (33%). Ninety‐one bacterial or fungal isolates were recovered (1.6 per specimen), 54 (0.9 per specimen) aerobic or facultative bacteria, 8 (0.1 per specimen) Candida sp., and 31 (0.6 per specimen) strict anaerobes. The predominant aerobic and facultative bacteria were Staphylococcus aureus (23 isolates), Streptococcus sp. (16), and Escherichia coli (6). The predominant anaerobes included Bacteroides sp. (12, including 9 Bacteroides fragilis group) and Pepto‐streptococcus sp. (11). Single bacterial isolates were recovered in 32 (55%) patients, 18 of which were S. aureus. Twenty‐five beta‐lactamase‐producing bacteria were detected in 22 (51%) of the 43 tested patients. These included 16 S. aureus and 6 B. fragilis group. These data highlight the importance of anaerobic bacteria in the polymicrobial nature of secondarily infected diaper dermatitis.
TERBINAFINE: EFFICACY AND SAFETY IN THE TREATMENT OF DERMATOPHYTOSIS
Authors: TÜZÜN YALÇIN , KOTOGYAN AGOP , OGUZ OYA 
Published: May 2007

AbstractA double‐blind study with terbinafine was performed in 39 patients with dermatophyte infection, between 1987 and 1989, to compare the safety and efficacy of two dosage schedules of 125 mg twice daily versus 250 mg once daily. Mycologic assessments were negative by microscopic examination and Sabouraud's culture in 59% and 100% of patients in the first and the fourth weeks of treatment, respectively. There was no statistically significant difference between the two groups of patients receiving 125 mg b.i.d. and 250 mg q.d. with respect to the safety and efficacy of the treatment; however, the differences between the sums of clinical scores before and after the treatment were statistically significant. There were no adverse effects, and the drug was well tolerated.
SAPERCONAZOLE IN THE TREATMENT OF SYSTEMIC AND SUBCUTANEOUS MYCOSES
Authors: FRANCO LILIANA , GOMEZ IVAN , RESTREPO ANGELA 
Published: May 2007

AbstractIn a 2‐year period, 30 patients with culture‐proven mycoses (chromoblastomycosis, sporotrichosis, and paracoccid‐ioidomycosis) were treated with the new orally administered triazole, saperconazole (SPZ) (R66905). The daily dose varied from 100 to 200 mg. All patients responded to treatment; the mean time required to heal the lesions and convert the cultures to negative was 3.5 months for sporotrichosis, 4.6 for paracoccidioidomycosis, and 9.0 for chromoblastomycosis. Evaluation by a scoring system indicated that 36.6% of the patients achieved complete resolution of the pretherapy abnormalities, while the remaining (63.3%) experienced major improvement. No colateral effects were reported; there were no bone‐marrow or liver toxicities. SPZ is an effective drug for the treatment of the above‐mentioned mycoses and appears to be suitable for the control of chromoblastomycosis.
LIVER BIOPSY VERSUS ULTRASOUND IN METHOTREXATE‐TREATED PSORIASIS: A DECISION ANALYSIS
Authors: VERSCHUUR ARNAUD C. , VAN EVERDINGEN JANNES J.E. , COHEN ERNST B. , CHAMULEAU ROB A.F.M. 
Published: May 2007

AbstractBefore starting methotrexate therapy for cases of recalcitrant psoriasis, a liver biopsy has been usual in order to exclude cirrhosis and moderate or severe fibrosis, which are contraindications for methotrexate treatment. As mortality and morbidity of liver biopsy are not negligible, and as this invasive procedure is unpleasant for the patient and urges clinical admission, we evaluated the possibility of ruling out severe liver pathology by means of ultrasonography, which we compared to liver biopsy. We made this comparison by means of a decision tree. The advantages of this analysis are the clear definition of the decision problem and its alternatives, and the possibility of calculating the risk of each alternative, thus being able to choose the best diagnostic method. In this study, the results of various research groups are discussed, in which liver biopsy and liver ultrasound were compared. In our decision tree we used some of these results and other assumptions, based on comparable studies. We varied the biopsy mortality and the sensitivity of ultrasound to show the change in the risk of each alternative. Our analysis shows that the differences of expected values between the liver biopsy branch and the ultrasonography branch are relatively small. Therefore, we advise each center, which has at its disposal a specialist in liver ultrasonography, to re‐evaluate its guidelines with regard to the detection of severe liver pathology before starting methotrexate for the treatment of psoriasis.
PORPHYRIA CUTANEA TARDA AND HUMAN IMMUNODEFICIENCY VIRUS INFECTION
Authors: BLAUVELT ANDREW , ROSS HARRIS H. , HOGAN DANIEL J. , JIMENEZ‐ACOSTA FRANCISCO , PONCE ISMAEL , PARDO RUBE J. 
Published: May 2007

AbstractPorphyria cutanea tarda (PCT), a relatively uncommon disease, has recently been reported in patients infected with the human immunodeficiency virus (HIV). Although PCT and HIV infection may co‐exist by chance, the increasing number of reported cases suggest that HIV or an associated factor triggers the development of PCT in predisposed individuals. We report four additional cases of PCT in HIV seropositive patients and review the previously reported cases. The possible links between PCT and HIV are discussed. We believe the diagnosis of PCT should prompt investigation for HIV infection in all patients.