bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of bacterial contamination and medium-term oncological outcomes of intracorporeal anastomosis for colon cancer: A propensity score matching analysis
Authors: Kayano Hajime , Mamuro Nana , Kamei Yutaro , Ogimi Takashi , Miyakita Hiroshi , Nakagohri Toshio , Koyanagi Kazuo , Mori Masaki , Yamamoto Seiichiro 
Published: March 2024

BACKGROUND
Although intracorporeal anastomosis (IA) for colon cancer requires longer operative time than extracorporeal anastomosis (EA), its short-term postoperative results, such as early recovery of bowel movement, have been reported to be equal or better. As IA requires opening the intestinal tract in the abdominal cavity under pneumoperitoneum, there are concerns about intraperitoneal bacterial infection and recurrence of peritoneal dissemination due to the spread of bacteria and tumor cells. However, intraperitoneal bacterial contamination and medium-term oncological outcomes have not been clarified.
AIM
To clarify the effects of bacterial and tumor cell contamination of the intra-abdominal cavity in IA.
METHODS
Of 127 patients who underwent laparoscopic colon resection for colon cancer from April 2015 to December 2020, 75 underwent EA (EA group), and 52 underwent IA (IA group). After propensity score matching, the primary endpoint was 3-year disease-free survival rates, and secondary endpoints were 3-year overall survival rates, type of recurrence, surgical site infection (SSI) incidence, number of days on antibiotics, and postoperative biological responses.
RESULTS
Three-year disease-free survival rates did not significantly differ between the IA and EA groups (87.2% and 82.7%, respectively, P = 0.4473). The 3-year overall survival rates also did not significantly differ between the IA and EA groups (94.7% and 94.7%, respectively; P = 0.9891). There was no difference in the type of recurrence between the two groups. In addition, there were no significant differences in SSI incidence or the number of days on antibiotics; however, postoperative biological responses, such as the white blood cell count (10200 vs 8650/mm3, P = 0.0068), C-reactive protein (6.8 vs 4.5 mg/dL, P = 0.0011), and body temperature (37.7 vs 37.5 °C, P = 0.0079), were significantly higher in the IA group.
CONCLUSION
IA is an anastomotic technique that should be widely performed because its risk of intraperitoneal bacterial contamination and medium-term oncological outcomes are comparable to those of EA.
Clinical observation of extraction-site incisional hernia after laparoscopic colorectal surgery
Authors: Fan Bao-Hang , Zhong Ke-Li , Zhu Li-Jin , Chen Zhao , Li Fang , Wu Wen-Fei 
Published: March 2024

BACKGROUND
Laparoscopic colorectal cancer surgery increases the risk of incisional hernia (IH) at the tumor extraction site.
AIM
To investigate the incidence of IH at extraction sites following laparoscopic colorectal cancer surgery and identify the risk factors for IH incidence.
METHODS
This study retrospectively analyzed the data of 1614 patients who underwent laparoscopic radical colorectal cancer surgery with tumor extraction through the abdominal wall at our center between January 2017 and December 2022. Differences in the incidence of postoperative IH at different extraction sites and the risk factors for IH incidence were investigated.
RESULTS
Among the 1614 patients who underwent laparoscopic radical colorectal cancer surgery, 303 (18.8%), 923 (57.2%), 171 (10.6%), and 217 (13.4%) tumors were extracted through supraumbilical midline, infraumbilical midline, umbilical, and off-midline incisions. Of these, 52 patients developed IH in the abdominal wall, with an incidence of 3.2%. The incidence of postoperative IH was significantly higher in the off-midline incision group (8.8%) than in the middle incision groups [the supraumbilical midline (2.6%), infraumbilical midline (2.2%), and umbilical incision (2.9%) groups] (χ 2 = 24.985; P < 0.05). Univariate analysis showed that IH occurrence was associated with age, obesity, sex, chronic cough, incision infection, and combined diabetes, anemia, and hypoproteinemia (P < 0.05). Similarly, multivariate analysis showed that off-midline incision, age, sex (female), obesity, incision infection, combined chronic cough, and hypoproteinemia were independent risk factors for IH at the site of laparoscopic colorectal cancer surgery (P < 0.05).
CONCLUSION
The incidence of postoperative IH differs between extraction sites for laparoscopic colorectal cancer surgery. The infraumbilical midline incision is associated with a lower hernia rate and is thus a suitable tumor extraction site.
Reinforced tissue matrix to strengthen the abdominal wall following reversal of temporary ostomies or to treat incisional hernias
Authors: Lake Spencer P , Deeken Corey R , Agarwal Amit K 
Published: March 2024

BACKGROUND
Abdominal wall deficiencies or weakness are a common complication of temporary ostomies, and incisional hernias frequently develop after colostomy or ileostomy takedown. The use of synthetic meshes to reinforce the abdominal wall has reduced hernia occurrence. Biologic meshes have also been used to enhance healing, particularly in contaminated conditions. Reinforced tissue matrices (RTMs), which include a biologic scaffold of native extracellular matrix and a synthetic component for added strength/durability, are designed to take advantage of aspects of both synthetic and biologic materials. To date, RTMs have not been reported to reinforce the abdominal wall following stoma reversal.
AIM
To evaluate the effectiveness of using an RTM to reinforce the abdominal wall at stoma takedown sites.
METHODS
Twenty-eight patients were selected with a parastomal and/or incisional hernia who had received a temporary ileostomy or colostomy for fecal diversion after rectal cancer treatment or trauma. Following hernia repair and proximal stoma closure, RTM (OviTex® 1S permanent or OviTex® LPR) was placed to reinforce the abdominal wall using a laparoscopic, robotic, or open surgical approach. Post-operative follow-up was performed at 1 month and 1 year. Hernia recurrence was determined by physical examination and, when necessary, via computed tomography scan. Secondary endpoints included length of hospital stay, time to return to work, and hospital readmissions. Evaluated complications of the wound/repair site included presence of surgical site infection, seroma, hematoma, wound dehiscence, or fistula formation.
RESULTS
The observational study cohort included 16 male and 12 female patients with average age of 58.5 years ± 16.3 years and average body mass index of 26.2 kg/m2 ± 4.1 kg/m2. Patients presented with a parastomal hernia (75.0%), incisional hernia (14.3%), or combined parastomal/incisional hernia (10.7%). Using a laparoscopic (53.6%), robotic (35.7%), or open (10.7%) technique, RTMs (OviTex® LPR: 82.1%, OviTex® 1S: 17.9%) were placed using sublay (82.1%) or intraperitoneal onlay (IPOM; 17.9%) mesh positioning. At 1-month and 1-year follow-ups, there were no hernia recurrences (0%). Average hospital stays were 2.1 d ± 1.2 d and return to work occurred at 8.3 post-operative days ± 3.0 post-operative days. Three patients (10.7%) were readmitted before the 1-month follow up due to mesh infection and/or gastrointestinal issues. Fistula and mesh infection were observed in two patients each (7.1%), leading to partial mesh removal in one patient (3.6%). There were no complications between 1 month and 1 year (0%).
CONCLUSION
RTMs were used successfully to treat parastomal and incisional hernias at ileostomy reversal, with no hernia recurrences and favorable outcomes after 1-month and 1-year.
Influence of different magnetic forces on the effect of colonic anastomosis in rats
Authors: Tian Bo-Yan , Zhang Miao-Miao , Ma Jia , Lyu Yi , Yan Xiao-Peng 
Published: March 2024

BACKGROUND
Despite much work having been conducted on magnetic compression anastomosis (MCA) in the digestive tract, there are no reports on the influence of magnetic force on the anastomosis.
AIM
To investigate the effect of different magnetic force magnets on the MCA of the digestive tract.
METHODS
Two groups of magnets of the same sizes but different magnetic forces were designed and produced. A total of 24 Sprague-Dawley rats were randomly assigned into two groups (powerful magnet group and common magnet group), with 12 rats in each group. Two types of magnets were used to complete the colonic side-to-side anastomosis of the rats. The operation time and magnet discharge time were recorded. The anastomotic specimens were obtained 4 wk after the operation and then the burst pressure and diameter of the anastomosis were measured, and the anastomosis was observed via the naked eye and subjected to histological examination.
RESULTS
The magnetic forces of the powerful and common magnet groups at zero distance were 8.26 N and 4.10 N, respectively. The colonic side-to-side anastomosis was completed in all 24 rats, and the operation success rate and postoperative survival rate were 100%. No significant difference was noted in the operation time between the two groups. The magnet discharge time of the powerful magnet group was slightly longer than that of the common magnet group, but the difference was not statistically significant (P = 0.513). Furthermore, there was no statistical difference in the burst pressure (P = 0.266) or diameter of magnetic anastomosis (P = 0.095) between the two groups. The gross specimens of the two groups showed good anastomotic healing, and histological observation indicated good mucosal continuity without differences on healing.
CONCLUSION
In the rat colonic side-to-side MCA model, both the powerful magnet with 8.26 N and the common magnet with 4.10 N showed no significant impact on the anastomosis establishment process or its effect.
Clinical efficacy and safety of erlotinib combined with chemotherapy in the treatment of advanced pancreatic cancer: A meta-analysis
Authors: Liu Xiao-Yan , Pan Hong-Nian , Yu Yue 
Published: March 2024

BACKGROUND
Advanced pancreatic cancer is resistant to chemotherapeutic drugs, resulting in limited treatment efficacy and poor prognosis. Combined administration of the chemotherapeutic gemcitabine and erlotinib is considered a potential first-line treatment for advanced pancreatic cancer. However, their comparative benefits and potential risks remain unclear.
AIM
To assess the clinical efficacy and safety of erlotinib combined with other chemotherapy regimens for the treatment of advanced pancreatic cancer.
METHODS
Literature on the clinical efficacy and safety of erlotinib combined with chemotherapy for advanced pancreatic cancer was retrieved through an online search. The retrieved literature was subjected to a methodological qualitative assessment and was analyzed using the RevMan 5.3 software. Ten randomized controlled trials involving 2444 patients with advanced pancreatic cancer were included in the meta-analysis.
RESULTS
Compared with chemotherapeutic treatment, erlotinib combined with chemotherapy significantly prolonged the progression-free survival time of pancreatic cancer patients [hazard ratio (HR) = 0.78, 95%CI: 0.66–0.92, P = 0.003]. Meanwhile, the overall survival (HR= 0.99, 95%CI: 0.72–1.37, and P = 0.95) and disease control rate (OR = 0.93, 95%CI: 0.45–0.91, P = 0.84) were not significantly favorable. In terms of safety, the erlotinib and chemotherapy combination was associated with a significantly higher risk of diarrhea (OR = 3.59, 95%CI: 1.63–7.90, P < 0.05) and rash (OR = 3.63, 95%CI: 1.64–8.01, P < 0.05) compared with single-agent chemotherapy. Moreover, the risk of vomiting (OR = 1.27, 95%CI: 0.62–2.59, P = 0.51), regurgitation/anorexia (OR = 1.61, 95%CI: 0.25–10.31, P = 0.62), and infection (OR = 0.72, 95%CI: 0.28-1.87, P = 0.50) were not significant in either group.
CONCLUSION
Compared with a single chemotherapeutic modality, erlotinib combined with gemcitabine can prolong progression-free survival in pancreatic cancer, but does not improve survival benefit or disease control rate, and can increase the risk of diarrhea and rash.
Endoscopic ultrasound-guided lauromacrogol injection for treatment of colorectal cavernous hemangioma: Two case reports
Authors: Zhu Hua-Tuo , Chen Wen-Guo , Wang Jing-Jie , Guo Jia-Nan , Zhang Fen-Ming , Xu Guo-Qiang , Chen Hong-Tan 
Published: March 2024

BACKGROUND
Colorectal cavernous hemangioma is a rare vascular malformation resulting in recurrent lower gastrointestinal hemorrhage, and can be misinterpreted as colitis. Surgical resection is currently the mainstay of treatment, with an emphasis on sphincter preservation.
CASE SUMMARY
We present details of two young patients with a history of persistent hematochezia diagnosed with colorectal cavernous hemangioma by endoscopic ultrasound (EUS). Cavernous hemangioma was relieved by several EUS-guided lauromacrogol injections and the patients achieved favorable clinical prognosis.
CONCLUSION
Multiple sequential EUS-guided injections of lauromacrogol is a safe, effective, cost-efficient, and minimally invasive alternative for colorectal cavernous hemangioma.
Survey of Natural Radioactivity of Soil and Rock Samples and their Radiological Implications to Human Health in Ugwuele Quarry Mining Site, Uturu, Abia State, Nigeria
Authors: Echeweozo E. O. , Agwu K. K. , Ogada J.  C. , Ike P. O. 
Published: March 2024

This work measured the activity concentration of natural radionuclides 238U, 232Th and 40K in soil and rock samples collected in Ugwuele mining site and it surrounding communities in Uturu, Abia state, Nigeria. Fifteen different samples collected were analyzed. A NaI (Tl) spectrometry detector system was adopted for this research. The results obtained were used to estimate the radiological implication of the quarry mining in the study area. The average gamma activity obtained for 238U, 232Th and 40K in soil were 53.39 ± 3.08, 76.79 ± 9.66 and 1061.02 ± 15.72 Bq/kg respectively and 55.09 ± 5.71, 90.96 ± 16.10 and 1281.78 ± 6.38 Bq/kg respectively for rock samples. The calculated radiological hazard indices from Absorbed dose rate, Annual effective dose, Radium equivalent, internal hazard index and External hazard index gave 120.25 nGy/h, 0.147 msv/yr, 247.5 Bq/kg, 0.833 and 0.687 respectively. The average dose rate was higher than the recommended limit. Therefore, soil and rock materials found in Ugwuele could increase the radiological hazards on miners and residents of the area due to long time cumulative exposure.
Severe hypoxemia after radiofrequency ablation for atrial fibrillation in palliatively repaired tetralogy of Fallot: A case report
Authors: Li Zhi-Hang , Lou Lian , Chen Yu-Xiao , Shi Wen , Zhang Xuan , Yang Jian 
Published: March 2024

BACKGROUND
Patients with tetralogy of Fallot (TOF) often have arrhythmias, commonly being atrial fibrillation (AF). Radiofrequency ablation is an effective treatment for AF and does not usually cause severe postoperative hypoxemia, but the risk of complications may increase in patients with conditions such as TOF.
CASE SUMMARY
We report a young male patient with a history of TOF repair who developed severe hypoxemia after radiofrequency ablation for AF and was ultimately confirmed to have a new right-to-left shunt. The patient subsequently underwent atrial septal occlusion and eventually recovered.
CONCLUSION
Radiofrequency ablation may cause iatrogenic atrial septal injury; thus possible complications should be predicted in order to ensure successful treatment and patient safety.
Incapacidad permanente derivada de enfermedades encuadradas en el síndrome del espectro de desregulación: criterios de los equipos de valoración versus judiciales
Authors: Catalán Mejía Gema 
Published: March 2024

En los últimos años se han incrementado las enfermedades relacionadas con las patologías encuadradas dentro del síndrome del espectro de desregulación, o enfermedades de sensibilización central, no conociéndose las causas de estos padecimientos.
Este artículo analiza el tratamiento jurídico de estas patologías a efectos de su reconocimiento como situación incapacitante permanente en la seguridad social. Para ello es necesario adentrarse en el conocimiento nosológico de estas enfermedades, analizando las peculiaridades de aquellas que generan un mayor impacto a nivel incapacitante, centrando este análisis en tres enfermedades encuadradas en este síndrome, fibromialgia, síndrome de fatiga crónica y síndrome de hipersensibilidad electromagnética, por ser las enfermedades que presentan un mayor número de personas afectadas y un mayor impacto en el ámbito laboral. Se incidirá en las características fundamentales de este tipo de enfermedades que, en los casos en los que la afectación patológica refiera una especial gravedad, podrán ser susceptibles de reconocimiento incapacitante permanente, a través del tratamiento con el que se abordan estas situaciones en el ámbito administrativo de gestión de la seguridad social y posteriormente por parte de jueces y tribunales.
Enhancing the Science Process Skills through Phet Simulation
Authors: Parthiban J  , Dr. Leo Stanly S  
Published: March 2024

The aim of this study was to understand the science process skills among IX standard students with respect to Phet simulation. Science education is much important to understand day to day life concepts and develops problem solving skills of the students. The single group design was adopted during the experiment. The investigator adopted purposive sampling technique for this study. The sample consists of 30 Students. Generally, science process skills are essential to understand science concepts. The science process skills are classified basic and integrated process skills. The concept of chemical bonding in class IX is little complex to understand. To teach the concept, teacher needs an effective method. So, the investigator has adopted Phet simulation to understand the science process skills. Science process skills are the competencies and techniques of scientific methods which is necessary and sufficient condition to discover scientific knowledge. Phet simulations are interactive simulations that may scaffold the students to understand the concepts in terms of science process skills. This proposed study helped the science teacher to modify his or her instructional strategies with technical support and also for enhancing the performance of students in science subject.
Skica za biografiju Salima Ćarića / Sketches for Salim Ćarić’s Biography
Authors: Filandra Šaćir 
Published: March 2024

Tekst predstavlja prilagođeno izlaganje sa naučne konferencije ZAVNOBiH u retrospektivi: evaluacija historijske važnosti i savremene relevantnosti za društvo i državu koja je organizirana povodom 80. godišnjice od Prvog zasjedanja ZAVNOBiH-a. Konferencija je održana 20. novembra 2023. godine na Univerzitetu u Sarajevu - Fakultetu političkih nauka.
The text represents an adapted presentation delivered at the scientific conference ZAVNOBiH in Retrospect – Evaluating Its Historical Importance and Contemporary Relevance for Society and the State, organized on the occasion of marking the 80th Anniversary of the First Session of ZAVNOBiH. The conference was held at the University of Sarajevo - Faculty of Political Sciences, on 20 November 2023.
80 godina ZAVNOBiH-a (1943–2023) – Bosna je bosanska / The 80th Anniversary of ZAVNOBiH (1943–2023) – Bosnia is Bosnian
Authors: Lavić Senadin 
Published: March 2024

Tekst predstavlja prilagođeno izlaganje sa naučne konferencije ZAVNOBiH u retrospektivi: evaluacija historijske važnosti i savremene relevantnosti za društvo i državu koja je organizirana povodom 80. godišnjice od Prvog zasjedanja ZAVNOBiH-a. Konferencija je održana 20. novembra 2023. godine na Univerzitetu u Sarajevu - Fakultetu političkih nauka.
The text represents an adapted presentation delivered at the scientific conference ZAVNOBiH in Retrospect – Evaluating Its Historical Importance and Contemporary Relevance for Society and the State, organized on the occasion of marking the 80th Anniversary of the First Session of ZAVNOBiH. The conference was held at the University of Sarajevo - Faculty of Political Sciences, on 20 November 2023.
Research on Pitting Corrosion of Microalloyed High-Strength Steel Bars
Authors: Wu QingLong , Gu Shangjun , Wang Jie , Wei Fulong , Li Zhiying , Yang Hui , Li Changrong 
Published: March 2024

In this study, a series of soaking experiments were conducted in a simulated marine environment solution to explore the pitting corrosion behavior induced by four types of inclusions in microalloyed steel bars: Al2O3, MnS, Al2O3-(Ti, V, Nb)N, and Al2O3-MnS-(Ti, V, Nb)N. In the early stage of corrosion, due to the high-density lattice distortion zone around the MnS and Al2O3 inclusions, along with the fact that these inclusions are not closely connected with the steel matrix, microcracks can occur leading to the initial corrosion of MnS in the Cl− environment. The corrosion rate of Al2O3 is the second highest after MnS, and clusters of Al2O3 can further accelerate the corrosion rate. The lattice distortion density around (Ti, V, Nb)N precipitates is significantly lower than that around MnS and Al2O3 inclusions. Additionally, (Ti, V, Nb)N is closely connected with the steel matrix without any microvoids. Therefore, (Ti, V, Nb)N is not sufficient to induce pitting corrosion of the matrix. The trend of pitting corrosion induced by the four types of inclusions, Al2O3, MnS, Al2O3-(Ti, V, Nb)N, and Al2O3-MnS-(Ti, V, Nb)N, is as follows: MnS &gt; Al2O3 &gt; Al2O3-MnS-(Ti, V, Nb)N &gt; Al2O3-(Ti, V, Nb)N.
Impact of physical activity on postural stability in pregnant and postpartum women
Authors: Roshko Julia , Stefańska Małgorzata , Skrzek Anna 
Published: March 2024

PurposeRegular physical activity is recommended by the WHO for women in the perinatal period as one of the basic factors determining the physiological course of pregnancy, childbirth and the postpartum period. The study aimed to identify the relationship between regular physical training of pregnant women, carried out in the second and third trimesters of pregnancy, and postural stability during the perinatal period.Methods58 women in the first trimester of pregnancy took part in the study and were divided into two groups according to their own choice. The exercise group participated in physical training three times a week during the second and third trimesters of pregnancy. The non-exercise group did not engage in additional physical activity. All subjects underwent three postural stability tests using a stabilograph.ResultsIn assessing posture stability parameters, significant differences were found only in body coordination in the active group of women. The exercise group showed statistically significantly lower values of the stabilogram parameters (better postural stability) obtained postpartum compared to those taken during pregnancy. There were no significant differences between the results taken during pregnancy. In the group of non-exercising women, no significant differences were observed between the second measurement during pregnancy and the measurement made postpartum.ConclusionsIt has been shown that physical activity has a significant impact on improving the coordination of women during pregnancy and postpartum. Women participating in regular physical training were characterised by smaller stabilogram deflections and better postural control compared to the control group.