bluuebunny/crossref_metadata_2025_split huggingface dataset:
Periodontal vaccines via plantibodies: Bridging the gap between aspiration and achievement
Authors: Vinayaka Ambujakshi Manjunatha 
Published: April 2024

Periodontitis, a multifaceted immune-inflammatory disorder, is intricately linked to systemic conditions such as cardiovascular disease and diabetes mellitus. Recent advancements in cellular and molecular biology have catalyzed the development of innovative vaccination strategies for various viral diseases. The concept of vaccination, pioneered by Edward Jenner in the late 18th century, capitalizes on the phenomenon of acquired immunity following recovery from an illness. Jenner's groundbreaking work with cowpox virus, which conferred cross-protection against smallpox, laid the foundation for modern vaccination practices.The advent of microbial genome sequencing and bioinformatics has revolutionized our ability to explore the genetic makeup of human pathogens comprehensively. This approach holds promise for identifying novel targets for antimicrobial drugs and vaccines, providing new avenues for combating infectious diseases.Given the pervasive nature of periodontal disease, there is an imperative need for effective management and prevention strategies. In the realm of immunization, the emergence of plant-based vaccines represents a novel paradigm. This review employed various search engines, including PubMed, Embase, Web of Science, Cochrane, Medline, and Google Scholar, to identify pertinent articles in medical and dental research. The findings from these studies underscore the potential efficacy of plant-derived vaccines in addressing a diverse range of disorders, including periodontal disease.This comprehensive review sheds light on the broad spectrum of applications of plant-based vaccines in periodontal care. By harnessing the unique properties of plant-derived antigens, these vaccines hold promise for offering safe, effective, and scalable solutions for the prevention and management of periodontitis. Further research and clinical trials are warranted to explore the full potential of plant-based vaccines in revolutionizing periodontal therapeutics.
The Effects of Encapsulation and Double-layer Emulsion of Peanut Oil on in vitro Rumen Degradability Rates and Fermentation Profile in Sheep
Authors: Budiman A. , Nurhadi B. , Supratman H. , Rahman M.M. , Yanza Y.R. , Hernaman I. 
Published: April 2024

Background: Peanut oil is rich in polyunsaturated fatty acids (PUFAs) and plays an important role in human and animal health. PUFAs are generally undergo to the biohydrogenation (BH) process by the rumen microbes. The single-layer emulsion encapsulation has been used in sheep diet. However, a limited reference was found concerning double-layer techniques to protect the essential PUFAs from BH process in the rumen. Methods: EDLEPO was made with a matrix of peanut oil, whey protein isolate (WPI), microcrystalline cellulose (MCC) and maltodextrin at 40: 2.5: 7.5: 55. The first layer was the binding of WPI with peanut oil and the second layer is the binding of WPI with MCC. Moreover, the in vitro experiment was designed with 5 treatments separated by CON group (0 g/kg EDLEPO) and experimental groups which are leveled by EDLEPO inclusion (25, 50, 75 and 100 g/kg levels of EDLEPO) in the buffered sheep’s rumen. Result: Increased levels of EDLEPO inclusion reduced rumen ammonia-N concentration (P less than 0.05) by a linear response. Hence, increased levels of EDLEPO inclusion increased rumen degradability rates expressed as IVDMD and IVOMD up to 12% and 9%, respectively, by a linear response (P less than 0.05). No significant differences were found between treatments on pH value, VFAs and total gas production. However, the increased levels of EDLEPO inclusion reduced CH4 concentration expressed as CH4/IVDMD and CH4/IVOMD up to 9% and 17% (P less than 0.05). It can be concluded that the EDLEPO inclusion in the diet increased in vitro rumen degradability rates with no negative effects on the rumen fermentation profile.
Estimativa do Número da Curva (CN) e sua adaptação ao contexto das Paisagens Mineiras
Authors: Albuquerque Cláudia Campos de , Brasil Maria Carolina Oliva , Mateus Nelson Pedro Antonio , Macedo Diego Rodrigues , Ribeiro Sónia Maria Carvalho 
Published: April 2024

Os recursos hídricos são essenciais para a manutenção da vida e da dinâmica terrestre. Para entender as dinâmicas entre recursos hídricos e uso do solo em diferentes paisagens as análises espaciais são ferramentas valiosas. Uma das metodologias amplamente utilizadas é o Soil Conservation Service (SCS), que se baseia no coeficiente do Número da Curva (CN), dentre outros parâmetros. No entanto, o método e a estimativa do coeficiente CN foi desenvolvida para um contexto de paisagem específico nos Estados Unidos, e não é necessariamente adequada para outras áreas. Adaptar o coeficiente CN para o contexto do estado de Minas Gerais, pode auxiliar no estudo e caracterização da hidrologia nas paisagens do estado, contribuindo para representar recursos hídricos no contexto da paisagem. Este trabalho estimou o CN tabulado pelo SCS e usando álgebra de mapas refinou o coeficiente para o contexto específico de Minas Gerais, com base em dados espaciais que estão diretamente relacionados à hidrodinâmica da região. Como resultado, foi criado um mapa de CN tabulado e um mapa de CN refinado adaptado para o estado de Minas Gerais, cujos dados foram validados com informações hidrológicas da bacia do Rio Doce. A estimativa de CN para valores altos indica locais de escoamento superficial alto e baixa infiltração. O CN tabelado acima de 80 representa 13 % da área total do estado de Minas Gerais. Já as estimativas para o CN refinado mostram que 40% da área total do estado possui CN acima 80. Valores do CN tabulado e refinado foram comparadas e validadas. Este estudo destaca a importância de adaptar as metodologias existentes às condições das paisagens locais contribuindo para dar subsídios para atingir metas globais como Objetivos do Desenvolvimento Sustentável ODS 6 (Garantir disponibilidade e manejo sustentável da água e saneamento para todos), ODS 11 (Tornar as cidades e os assentamentos humanos inclusivos, seguros, resilientes e sustentáveis) e ODS 15 (Proteger, recuperar e promover o uso sustentável dos ecossistemas terrestres, gerir de forma sustentável as florestas, combater a desertificação, deter e reverter a degradação da terra e deter a perda de biodiversidade.)
Pemerolehan Bahasa dan Penggunaan Bahasa Anak Usia Sekolah Dasar
Authors: Ruyatul Hilal Muhtar Tri Mahajani, 
Published: April 2024

<p>Abstract. The present study aims to examine a description of language acquisition and its usage by pupils in their daily conversations. This study employed a longitudinal case study and applieda descriptive method, while it used a content analysis for the research technique. The resultrevealed a finding upon the young learner language acquisition and its usage, the language acquisition included Bahasa Indonesia, Javanese language, Sundanese language and English language. The uses of language for a system, a personal expression, and an interpersonal expression were broad good enough and were uttered structurally, however, mistakes were founded on applying structures and making meaning to language in use. To pupils whom are at elementary school level, they have acquired a range of language structure and its use for perfection. Their parents, teachers, and their society have any real and valuable<br />influence over them in the way language is structured and is used for exemplifying examples ofthe perfect language acquisition.</p>
Upaya Peningkatan Hasil Belajar Lompat Jauh Melalui Pendekatan Bermain Lompat Tali pada Siswa Kelas IV Sekolah Dasar
Authors: Warsiyanti Y. 
Published: April 2024

<p>Abstract. The students' long jump learning outcomes still do not meet the KKM. This study aims to describe the process of improving long jump learning outcomes through the rope jumping approach to fourth grade students of Katekan 2 Elementary School in Gantiwarno District, Klaten Regency. This research is a classroom action research. The subjects in this study were grade IV students of SDN 2 Katekan in Gantiwarno District, Klaten Regency with a total of 20 students. The instrument used was a long jump performance test. The data analysis<br />technique used in this study is descriptive qualitative and quantitative. Based on the results of the study, it can be concluded that the effort to increase the results of the long jump through rope jumping in the fourth grade students of Katekan Elementary School 2 of Gantiwarno Subdistrict, Klaten Regency was successfully marked by an increase in the average value of students. The average value of students in pre-action activities was 55.94 with a percentage of completeness of 40%. This condition experienced an increase in the average value of students<br />in the first cycle, namely to be equal to 65.63 and the percentage of completeness by 60%. However, this increase has not yet reached the target set previously. Then after proceeding to the second cycle the students' long jump average value increased to 70.50 with the percentage of completeness of 90%. This shows that the previously set target has been reached so that the research is stopped in cycle II. The long jump learning process using the play approach takes place dynamically and pleasantly. Students actively carry out the task and observe the movement of the long jump technique and discuss each other with friends. All aspects of<br />assessment are mastered by students. The students' long jump ability increases with the markedby all KKM complete students (Minimum Completion Criteria), namely 67.</p>
Bilateral Femoral Neck Pseudarthrosis in an Adolescent Girl With Congenital Spondyloepiphyseal Dysplasia. The Treatment Journey
Authors: Stergiadou Styliani , Rigopoulos Nikolaos , Hantes Michael , Malizos Konstantinos N. 
Published: April 2024

Case:
We describe the surgical management of a girl with dwarfism and congenital spondyloepiphyseal dysplasia, who presented in adolescence with coxa vara and bilateral pseudarthrosis between the femoral neck and the diaphysis, with asymmetric distal migration at both sites and leg length discrepancy. The patient at 16 years underwent valgus osteotomy in situ and femoral neck fixation in the left hip. The right hip was operated 19 months later.

Conclusion:
Hip dysplasia is common in spondyloepiphyseal dysplasia, but a debilitating nontraumatic bilateral pseudarthrosis at the base of the femoral neck has not been previously reported. Valgus corrective osteotomies of the femur in situ led to union and allowed the patient to walk.
The impact of elder abuse training on subacute health providers and older adults: Study protocol for a randomized control trial
Authors: Cavuoto Marina G. , Markusevska Simona , Stevens Catriona , Reyes Patricia , Renshaw Gianna , Peters Micah DJ , Dow Briony , Feldman Peter , Gilbert Andrew , Manias Elizabeth , Mortimer Duncan , Enticott Joanne , Cooper Claudia , Antoniades Josefine , Appleton Brenda , Nakrem Sigrid , O’Brien Meghan , Ostaszkiewicz Joan , Eckert Marion , Durston Cheryl , Brijnath Bianca 
Published: April 2024

Abstract
Introduction: Elder abuse often goes unreported and undetected. Older people may be ashamed, fearful or otherwise reticent to disclose abuse; and many health providers are not confident in asking about it. In the No More Shame study, we will evaluate a co-designed, multi-component intervention that aims to improve health providers’ recognition, response, and referral of elder abuse.
Methods: This is a single-blinded, pragmatic, cluster randomised controlled trial. Ten subacute hospital sites (i.e., clusters) across Australia will be allocated 1:1, stratified by state to a multi-component intervention comprising a training program for health providers, implementation of a screening tool and use of site champions, or no additional training or support. Outcomes will be collected at baseline, 4 and 9 months. Our co-primary outcomes are health providers’ knowledge of responding to elder abuse; and older people’s quality of life. We will include all inpatients at participating sites, aged 65+ (or aged 50+ if Aboriginal or Torres Strait Islander), who are able to provide informed consent and all unit staff who provide direct care to older people; a sample size of at least 92 health providers and 612 older people will provide sufficient power for primary analyses.
Results: Recruitment will commence in October 2023.
Discussion: This will be one of the first trials in the world to evaluate a multi-component elder abuse intervention. If successful, it will provide the most robust evidence base to date for health providers to draw on to create a safe environment for reporting, response, and referral.
Trial registration: ANZCTR, ACTRN12623000676617p. Registered 22 June 2023, https://www.anzctr.org.au/ACTRN12623000676617p.aspx
Influence of land use type and rainfall on the water quality of North Canal basin in Beijing, China
Authors: Zhang Xueyu , Yu Jingshan , Wang Qianyang , Sun Juan , lv Boyu , Wang Qixin 
Published: April 2024

Abstract
Influence of land use type and rainfall on the water quality of North Canal basin in Beijing was evaluated.The monthly monitoring data of 63 water quality stations from 2015 to 2021, the land use type data from 1980 to 2020, the rainfall and runoff data of the North Canal basin in Beijing from 1919 to 2021 were analyzed. Results showed that the water quality of the North Canal basin in Beijing was getting better year by year, and showed temporal and spatial variations. In general, water quality in flood season was better than that in non-flood season, and better in upstream than that in downstream.Cluster analysis showed that the 63 water quality stations were divided into three types. Spearman correlation analysis results clarified that the concentration of water quality indexes were significant negatively correlated with forest land, and a positive relationship between cultivated land and water quality indexes in flood season or non-flood season.In addition, the concentration of CODMn, NH3 and TP were significantly positively correlated with rainfall in flood season, and the concentration of TN was negatively related to rainfall in non-flood season.This study provided important support for scientific and reasonable promotion of urban water environment management at the basin scale.
"Missed Prenatal Ultrasounds" unspoken issue of women having Antenatal care at Primary health care settings: A qualitative exploratory study in District Hazro, Pakistan
Authors: Khan Bushra Asif Ali , Ahmed Jawaria Mukhtar , Jabeen Rawshan , Mahmood Humaira , Khan Muhammad Arif , Rabbani Unaib , Muhammad Ameer 
Published: April 2024

Abstract
Background This qualitative study aimed to explore women's experiences and perceptions regarding barriers to accessing ultrasound scans at primary healthcare level.Method Altogether, four focus group discussions (FGDs) involving 36 pregnant women who had received prenatal care at facilities between February and September 2021 were conducted. Using a purposive sampling technique participants provided informed consent before data collection during guided FGDs.Result Thematic analysis of the data using NVivo 12 revealed recurring themes explaining underutilization of ultrasound scans at this level of healthcare. The study highlighted challenges faced by women at primary health care facilities, emphasizing the potential gaps in caregivers' ability to provide comprehensive counseling about the importance and safety of ultrasound scans in fetal growth monitoring. Addressing staff training and accountability emerged as essential areas requiring attention. Additionally, allocating more resources to alleviate financial burdens associated with accessing ultrasound services was a key recommendation.Conclusion In conclusion, this study revealed diverse barriers hindering women's access to ultrasound services at primary healthcare. It suggests targeted interventions focusing on staff training, improving facility support, and addressing financial constraints to enhance accessibility and utilization of ultrasound scans among pregnant women attending Primary Health Care facilities.
The feasibility and acceptability of engaging older adults living with multiple long-term conditions, frailty, and a recent deterioration in health in research: findings from the Lifestyle in Later Life – Older People’s Medicine (LiLL-OPM) study
Authors: Hurst Christopher , Dismore Lorelle , Granic Antoneta , Noble Jane M. , Hillman Susan J. , Witham Miles D. , Sayer Avan A. , Robinson Sian M. 
Published: April 2024

Abstract

Background Older adults living with multiple long-term conditions (MLTC, also known as multimorbidity) and frailty are more likely to experience a deterioration in their health requiring specialist referral or hospital admission than individuals without these syndromes. However, this group of older people are underserved by research meaning that there is a limited evidence base for their care. This study therefore aimed 1) to determine if it is feasible to recruit and collect quantitative data to describe the health and lifestyle of older adults living with MLTC, frailty and a recent deterioration in health and 2) to assess if taking part in research is acceptable to this group of older adults.Methods Participants were approached and recruited for this study via an Older People’s Medicine Day Unit in Newcastle upon Tyne, UK. The study took a mixed methods approach, involving quantitative and qualitative data collection. To determine the feasibility of carrying out research in this group, we quantified recruitment rate and collected data on the health and lifestyle, including diet and physical activity, of the participants. Qualitative semi-structured interviews were undertaken to assess acceptability. Two separate interviews were carried out focusing on involving older adults in research and the participants’ experiences of taking part in the research. Interviews were analysed using thematic analysis.Results Fifty patients were approached to participate in the study with twenty-nine (58%) successfully recruited. It was feasible to collect information to describe the health and lifestyle of these older adults who demonstrated very low levels of physical activity. Participants reported that taking part in the research was acceptable to them with interview analysis generating three themes 1) developing a meaningful partnership, 2) enabling factors to participation: research at home with flexible delivery and 3) social and psychological benefits of research participation.Conclusions It is feasible and acceptable to recruit and carry out research with this underserved group of older adults. Participants found taking part in this research to be acceptable and reported overall positive experiences of their involvement in the study and indicated that they would be willing to contribute to further research in the future.
The collective dynamics of frustrated biological neuron networks
Authors: Sun Bo , Li Guanyu , Starman Alia , Chappell Patrick , LeFebre Ryan , Mugler Andrew 
Published: April 2024

Abstract
To maintain normal functionality, it is necessary for a multicellular organism to generate robust responses to external temporal signals. However, the underlying mechanisms to coordinate the collective dynamics of cells remain poorly understood. Here we study the calcium activity of micropatterned biological neuron networks excited by periodic ATP stimuli. Combining quantitative experiments, physical and biological manipulation of cells, as well as mathematical modeling, we show that isolated cells in a network become more synchronized at longer period of stimuli through noise cancellation. However, slowly varying external signal also increases gap junction coupling between connected nodes in the network; and gap junction mediated communication may destroy network synchronization due to special nonlinear bifurcations exhibited by the excitable dynamics of neuronal cells. Based on our results, we propose that a biological neuron network supported by gap junctional communication encodes external temporal signals in its network dynamics. A sparely connected network approaches synchronization as input signal slows down, whereas a highly connected network enters dynamic frustration in the same situation.
Genome-wide Association Studies for Immune Response and Resilience to Aleutian Disease in Mink
Authors: Hu Guoyu , Do Duy Ngoc , Manafiazar Ghader , Kelvin Alyson A. , Plastow Graham , Sargolzaei Mehdi , Wang Zhiquan , Miar Younes 
Published: April 2024

Abstract

Background
Aleutian disease (AD), caused by the Aleutian mink disease virus, is a significant health concern for mink, resulting in substantial economic losses for the mink industry. Although phenotypic selection of AD-resilient mink based on immune response and/or indicator traits is practiced by some mink farms, the genetic architecture of immune response and resilience to AD has not been widely explored. Thus, the objective of this study was to conduct the first genome-wide association studies (GWAS) analyses to identify genomic regions and genes associated with immune response and feed-intake-related resilience to AD in mink.
Methods
The genotypes and phenotypes, including two immune response traits measured by antigen-based enzyme-linked immunosorbent assay (ELISA-G) and iodine agglutination test (IAT) and two feed-intake-related resilience traits measured by the daily variation in feed intake (Varf) and proportion of off-feed days (DOF), of 1,411 mink from an AD-positive farm was used in this study. The de-regressed breeding values were derived from the estimated breeding values for each trait and utilized as pseudo-phenotypes in the analyses.
Results
A total of 17, eight, and seven significant (false-discovery-rate-adjusted-p-value (q) <0.01) single nucleotide polymorphisms (SNP) were detected to be associated with ELISA-G, IAT, and DOF, respectively, but no significant SNP was detected for Varf. A total of 141 genes were annotated from the significant SNPs for ELISA-G, and three of them, MPIG6B, RUNX2, and C4A, might have important roles in immune-mediated responses to AD. Two (TNFRSF11Aand C4A) of the 44 genes annotated in IAT were found to be involved in the immune system process. In addition, 42 genes were annotated in DOF, and two of them, ADCY7 and CNDP2, were related to feed intake or appetite. A total of five significant (q<0.05) overrepresented gene ontology enrichment terms, which play important roles in the adaptive immune response or complement system, were detected for ELISA-G.
Conclusions
The significant SNPs and genes detected in this study help provide a better understanding of the genetic architecture underlying the immune response and resilience of mink to AD and the potential for improving the resilience of mink to AD using marker-assisted/genomic selection.