bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selenium Nanoparticles Enhance NK Cell‐Mediated Tumoricidal Activity in Malignant Pleural Effusion via the TrxR1‐IL‐18RAP‐pSTAT3 Pathway
Authors: Liu Shaowei , Li Naijian , Lai Haoqiang , Xu Ligeng , Zeng Yunxiang , Chen Xin , Huang Haoyang , Chen Tianfeng , Liu Jun , Wang Jinlin 
Published: March 2024

AbstractMalignant pleural effusion (MPE) poses a significant challenge in local treatment, primarily attributed to its intricate tumor immune microenvironment. The immunosuppression of natural killer (NK) cells within the microenvironment, exacerbated by selenium (Se) deficiency, constitutes a pivotal treatment bottleneck. Building upon prior investigations, this study delves into the impact and mechanisms of functionalized lentinan selenium nanoparticles (LET‐SeNPs) on NK cells in MPE, presenting a novel local treatment strategy for lung adenocarcinoma with malignant pleural effusion (MPE‐LA). The synergistic application of LET‐SeNPs serves to replenish Se levels in MPE, modulate NK cells, augment their quantity, restore and enhance their functionality. Additionally, LET‐SeNPs facilitate NK cells activation through the TrxR1‐IL18RAP‐pSTAT3 pathway, resulting in effective lung cancer cell eradication and reduced pleural effusion production. Furthermore, pre‐stimulation of NK cells by LET‐SeNPs, combined with CAR‐NK cell therapy, harnesses the innate immune system, exhibiting a potent anti‐tumor effect. This research introduces a compelling strategy to advance the clinical implementation of targeted nanomaterials or lead compounds with explicit targets and mechanisms, thereby enhancing NK cell therapy for comprehensive diagnosis and treatment of MPE.
Oxygen Driven Defect Engineering of Monolayer MoS2 for Tunable Electronic, Optoelectronic, and Electrochemical Devices
Authors: Abidi Irfan H. , Giridhar Sindhu Priya , Tollerud Jonathan O. , Limb Jake , Waqar Moaz , Mazumder Aishani , Mayes Edwin LH , Murdoch Billy J. , Xu Chenglong , Bhoriya Ankit , Ranjan Abhishek , Ahmed Taimur , Li Yongxiang , Davis Jeffrey A. , Bentley Cameron L. , Russo Salvy P. , Gaspera Enrico Della , Walia Sumeet 
Published: March 2024

AbstractMolybdenum disulfide (MoS2), a two‐dimensional (2D) semiconducting material harbors intrinsic defects that can be harnessed to achieve tuneable electronic, optoelectronic, and electrochemical devices. However, achieving precise control over defect formation within monolayer MoS2, remains a notable challenge. Here, an in‐situ defect engineering approach for monolayer MoS2 using a pressure‐dependent chemical vapor deposition (CVD) process is presented. Monolayer MoS2 grown in a low pressure CVD conditions (LP‐MoS2) produces sulfur vacancy (Vs) induced defect‐rich crystals primarily attributed to the oxygen‐deficient growth conditions. Conversely, atmospheric pressure CVD‐grown MoS2 (AP‐MoS2) passivates these defects with oxygen from ambient conditions. This disparity in defect profiles profoundly impacts crucial functional properties and device performance. AP‐MoS2 shows a drastically enhanced photoluminescence, which is significantly quenched in LP‐MoS2 attributed to in‐gap electron donor states induced by the Vs defects. However, the n‐doping induced in LP‐MoS2 generates enhanced photoresponsivity and detectivity in fabricated photodetectors compared to the AP‐MoS2‐based devices. Defect‐rich LP‐MoS2 outperforms AP‐MoS2 as channel layers of field‐effect transistors (FETs), as well as electrocatalytic material for hydrogen evolution reaction (HER). This work presents a single‐step CVD approach for in situ defect engineering in monolayer MoS2 and presents a pathway to control defects in other monolayer 2D materials.
Multifunctional Polyoxometalates‐Based Ionohydrogels toward Flexible Electronics
Authors: Wang Zhi‐Da , Bo Kai , Zhong Chen‐Long , Xin Yu‐Hang , Lu Guo‐Long , Sun Hang , Liang Song , Liu Zhen‐Ning , Zang Hong‐Ying 
Published: March 2024

AbstractMultifunctional flexible electronics present tremendous opportunities in the rapidly evolving digital age. One potential avenue to realize this goal is the integration of polyoxometalates (POMs) and ionic liquid‐based gels (ILGs), but the challenge of macrophase separation due to poor compatibility, especially caused by repulsion between like‐charged units, poses a significant hurdle. Herein, the possibilities of producing diverse and homogenous POMs‐containing ionohydrogels by nanoconfining POMs and ionic liquids (ILs) within an elastomer‐like polyzwitterionic hydrogel using a simple one‐step random copolymerization method, are expanded vastly. The incorporation of polyzwitterions provides a nanoconfined microenvironment and effectively modulates excessive electrostatic interactions in POMs/ILs/H2O blending system, facilitating a phase transition from macrophase separation to a submillimeter scale worm‐like microphase‐separation system. Moreover, combining POMs‐reinforced ionohydrogels with a developed integrated self‐powered sensing system utilizing strain sensors and Zn‐ion hybrid supercapacitors has enabled efficient energy storage and detection of external strain changes with high precision. This work not only provides guidelines for manipulating morphology within phase‐separation gelation systems, but also paves the way for developing versatile POMs‐based ionohydrogels for state‐of‐the‐art smart flexible electronics.
Space‐Efficient 3D Microalgae Farming with Optimized Resource Utilization for Regenerative Food
Authors: Liu Hai , Yu Siqin , Liu Bin , Xiang Shuhong , Jiang Minwen , Yang Fan , Tan Weiwei , Zhou Jianfei , Xiao Ming , Li Xiaojie , Richardson Joseph J , Lin Wei , Zhou Jiajing 
Published: March 2024

AbstractPhotosynthetic microalgae produce valuable metabolites and are a source of sustainable food that supports life without compromising arable land. However, the light self‐shading, excessive water supply, and insufficient space utilization in microalgae farming have limited its potential in the inland areas most in need of regenerative food solutions. Herein, this work develops a 3D polysaccharide‐based hydrogel scaffold for vertically farming microalgae without needing liquid media. This liquid‐free strategy is compatible with diverse microalgal species and enables the design of living microalgal frameworks with customizable architectures that enhance light and water utilization. This approach significantly increases microalgae yield per unit water consumption, with an 8.8‐fold increase compared to traditional methods. Furthermore, the dehydrated hydrogels demonstrate a reduced size and weight (≈70% reduction), but readily recover their vitality upon rehydration. Importantly, valuable natural products can be produced in this system including proteins, carbohydrates, lipids, and carotenoids. This study streamlines microalgae regenerative farming for low‐carbon biomanufacturing by minimizing light self‐shading, relieving water supply, and reducing physical footprints, and democratizing access to efficient aquatic food production.
Mimicking Emotional Chinese Calligraphy Using a Variable Stiffness Flexible Gripper
Authors: Han Yubing , Li Wanqing , Shi Bori , Zhang Ying , Xue Chang , Zhang Mengying , Guo Zhansheng , Wen Weijia , Zhang Xingcai , Zhang Tongyi , Wu Jinbo 
Published: March 2024

AbstractFlexible grippers require appropriate stiffness to ensure stability and efficiency in unpredictable environments. While combining materials with variable stiffness and elastomers holds significant promise in this regard, concurrently achieving actuation and stiffness modulation typically results in heightened structural complexity and responsiveness issues. In this study, a giant electrorheological dielectric elastomer (GERDE) with high dielectric and high electrorheological (ER) properties is obtained by introducing giant electrorheological particles into silicone elastomers, further substantiating the ability to functionally couple actuation and stiffness‐tuning, as well as application of a flexible gripper in mimicking emotive calligraphy. Specifically, GERDE exhibits better actuating (area strain rate of 33%) and ER performance (storage modulus increment of 1.5 MP) than existing conventional dielectric elastomer (DE) actuators (such as PDMS and VHB4910) under a low electric field. Compared to reported flexible grippers, bionic flexible grippers based on GERDE actuator have enhanced actuation, stiffness adjustment capability (i.e., stiffness is increased by 2.4 times), fast response (≈180 ms), and coupling effect, and can write Chinese calligraphy of different emotions by the same trajectory. This work provides ideas and methods for achieving the integration of actuator‐variable stiffness and emotional transmission in robots.
Pitch‐Switchable Metalens Array for Wavefront Profiling at Multiwavelength
Authors: Hu Yueqiang , Cai Yihao , Wei Wenzhi , Li Ling , Wang Hanbin , Wang Shuai , Yang Ping , Jia Honghui , Duan Huigao 
Published: March 2024

AbstractThe wavefront sensor is a crucial component in the adaptive optics system (AOS), responsible for detecting aberrated wavefronts. However, The Shack–Hartmann wavefront sensor with single‐pitch microlens array is limited in its adaptability to different observing conditions, affecting wavefront reconstruction accuracy. And conventional microlens arrays are wavelength‐specific. Here, a polarization‐dependent pitch‐switchable metalens array based on non‐interleaved silicon metasurfaces is proposed, capable of working at multiple wavelengths. By controlling the incident and outgoing light polarization, three metalens arrays with customized pitches can be switched at will. Furthermore, achromatic performance is achieved in the 950 nm and 1030 nm wavelengths through structural dispersion engineering. Finally, wavefront detection experiments are finally conducted to demonstrate the phase reconstruction with variable spatial resolution. The metalens array with high flexibility in wavefront sensor can further enhance the adaptability of AOS and has great potential for applications in light‐field imaging, and machine vision, etc.
Controllable Modulation of Third‐Order NLO Properties by Polymer‐Modified MOFs Core@Shell Nanoarchitecture
Authors: Huang Jing , Zhou Jiachao , Cui Yang , Geng Kangshuai , Zhao Yujie , Sun Yupei , Hou Hongwei 
Published: March 2024

AbstractThe delocalization and rearrangement of π electron clouds in space is the crucial source of regulating nonlinear optical (NLO) performance. Herein, a core‐shell metal organic framework (MOF)‐heterojunction is constructed to achieve the effect of tuning NLO properties by promoting charge transfer through multiple interactions between heterogeneous interfaces. [Cd(L)(4,4′‐bpy)(H2O)]n (Cd‐MOF) is selected to coat on polyaniline (PANI) surface to form PANI@Cd‐MOF. The constructed heterojunction displays an enhanced reverse saturation absorption (RSA) signal compared with Cd‐MOF, and it should be noted that the third‐order NLO refractive behavior changes from the self‐defocusing of Cd‐MOF to the self‐focusing of PANI@Cd‐MOF. It is proposed that high‐speed electronic communication bridges established via the rich hydrogen bond network (O… H‐N) and π–π interactions between heterogeneous interfaces can effectively modify the π electron cloud density that finally regulates the NLO properties. This work is believed to provide new avenues and insights for the design of third‐order NLO materials.
Luminophore with Multiple Emission Centers for Fluorescence/ Phosphorescence Dual Ratiometric Chemical Sensing in Aqueous Solution
Authors: Zhou Qian , Liu Yanxiong , Ma Xiurong , Fan Wenwen , Cheng Yi , He Runying , Meng Xian , Shi Yonggang , Cao Qiue , Zheng Liyan 
Published: March 2024

AbstractLuminescent materials with multiple emission centers are attracting more and more attentions due to their potential applications in multicolor displays, polychromatic imaging, information encryption, and ratiometric chemical sensing. Organic molecules with phosphorescence behavior at room temperature (RTP) provide idea candidate for constructing luminescent materials with multiple emission centers, which show great potentials for application in ratiometric chemical sensing owing to its long‐lived emission and high signal‐to‐noise ratio. However, developing RTP materials with multiple emission centers and their application in aqueous solutions remains a huge challenge. Herein, two chromophore isomers (p‐N‐DPC·(PF6)2 and m‐N‐DPC·(PF6)2) based on carbazole and naphthalene units are prepared by using pyridine quaternary ammonium salt as link to improve their solubility in water and form electron deficient centers to facilitate charge transfer (CT). p‐N‐DPC·(PF6)2 displayed multiple emissions behavior, including monomer fluorescence, dimer fluorescence, monomer phosphorescence, dimer phosphorescence, and CT phosphorescence. Especially, p‐N‐DPC·(PF6)2 exhibits monomer fluorescence, dimer fluorescence, and CT phosphorescence in an aqueous solution, which is successfully applied as self‐calibrated dual ratio luminescent sensor for phosphate detection. This study not only provides a strategy to construct luminophore with multiple emissions but also develops a fluorescence/ phosphorescence dual ratio luminescent sensor in an aqueous solution.
Highly Efficient Copper(I) Emitters Supported by Secondary Metal‐Ligand Interactions
Authors: Ying Ao , Tan Yao , Gong Shaolong 
Published: March 2024

AbstractThe most prominent way of tuning optoelectronic properties of copper(I) emitters is primary‐sphere ligand engineering, but little attention is placed on noncovalent interactions. Here, an effective strategy is demonstrated to introduce secondary metal‐ligand interactions into two‐coordinate Cu(I) emitters with the goals of optimizing conformations and improving optical properties. As a proof of concept, a panel of Cu(I) complexes is developed via chalcogen‐heterocyclic engineering on the 1,2‐positions of carbazole ligand. The S‐embedded complexes have distinct noncovalent metal‐ligand interactions originating from S···Cu orbital contacts, verified by single‐crystal structure and theoretical simulation. Thanks to the flattened conformations stabilized by secondary metal‐ligand interactions, the optimized Cu(I) emitters afford high emission quantum yields of up to 93% and short radiative lifetimes of down to 0.8 µs. Cu‐12BT and Cu‐12BF support the resultant organic light‐emitting diodes (OLEDs) delivering outstanding maximum external quantum efficiencies (EQEs) of 24.3% and 28.6%, respectively, among the best performance for Cu(I) emitters. The optimal devices based on Cu‐12BF also achieve 18.7% EQE at the practical luminance of 100 nits. This work unlocks the large potential of noncovalent interactions in developing excellent Cu(I) emitters for cost‐effective and high‐efficiency OLEDs.
Boosting Reverse Intersystem Crossing of TADF Emitter through Molecular Geometry Adaptation to Crystalline Host
Authors: Kreiza Gediminas , Javorskis Tomas , Orentas Edvinas , Kazlauskas Karolis 
Published: March 2024

AbstractRapid reverse intersystem crossing (RISC) is one of the prime concerns for blue thermally activated delayed fluorescence (TADF) emitters, as it reduces triplet exciton population, the root cause of detrimental triplet‐mediated annihilation processes that accelerate device efficiency roll‐off and degradation. This work introduces a new concept to tailor the RISC of TADF emitters through their molecular geometry adaptation to crystalline hosts bearing a similar donor‐acceptor structure. A meticulously designed crystalline host comprising isophthalonitrile acceptor (A) and carbazole‐derived donor (D) units, characterized by nearly orthogonal D‐A arrangement, has been demonstrated to alleviate singlet‐triplet energy gap (ΔEST) of the TADF dopant by forcing it to adopt a more twisted D‐A configuration, as corroborated by X‐ray diffraction (XRD) measurements. The approach not only significantly reduces the RISC activation energy, resulting in a remarkable tenfold boost of the RISC rate (above 107 s−1) and fourfold shortening of delayed FL lifetime (down to 1.5 µs), but also offers the additional benefit of suppressing conformational disorder of TADF dopant, producing a narrower emission bandwidth. The presented concept, based on crystalline host‐driven RISC engineering, is anticipated to have a profound impact on the development of high‐performance, stable blue‐emitting TADF organic light‐emitting diodes (OLEDs).
Designing Photochromic Materials La2MgSnO6:Er,Fe with Dynamic Luminescence Modulation for Dual‐mode Optical Information Reading
Authors: Kuang Rongyi , Lian Huiwang , Zhu Yunfei , Gu Simin , Huang Lin , Liu Bo‐Mei , Wang Jing 
Published: March 2024

AbstractInorganic photochromic luminescent materials hold immense promise as potential candidates for optical information storage applications. Unfortunately, static and single reading mode of photochromic luminescent materials in bright and dark environments pose a security threat to the stored information. Here, a novel material La2MgSnO6:Er3+,Fe3+ is developed, possessing both reversible photochromic and adjustable upconversion/downconversion photoluminescent (PL) properties. Upon exposure to 275 nm ultraviolet (UV) light, the sample changes in color from white to brown. And this transformation rapidly reverses when exposed to 365 nm UV light, resulting in a corresponding alteration in luminescence intensity. Notably, when combined with photochromic, the 980 nm excited upconversion PL maintains stable luminescence, while the 365 nm excited downconversion PL exhibits significant intensity changes. Inspired by this unique feature, a dark‐field selective dual‐mode reading is proposed that depends on the excitation wavelength, including static decrypt in long‐time cases and dynamic reading in time‐limited situations. These findings have the potential to revolutionize high‐security data storage applications and drive advancements in the field.
Recent Advances in 1D Photonic Crystals: Diverse Morphologies and Distinctive Structural Colors for Multifaceted Applications
Authors: Kou Donghui , Zhang Shufen , Ma Wei 
Published: March 2024

Abstract1D photonic crystals (1DPCs) with hierarchically structured lamellar periodic frameworks that enable precise control of light‐matter interactions and contribute robust structural colors represent a groundbreaking advancement in optical materials. The microstructural characteristics and the constituent material properties of these photonic materials play pivotal roles in determining their optical performance and functionality. In recent years, a diverse array of novel 1D photonic structures crafted from various materials emerged, showcasing their tremendous potential in advanced applications. This article provides an in‐depth review of the recent developments in 1DPCs, emphasizing their morphological designs, fabrication strategies, and optical applications. In detail, 1DPCs featuring distinct geometrical morphologies, including lamellar, helical, fibrous, spherical, and nanochained structures are systematically introduced, highlighting the unique optical properties arising from their periodic microstructures. Then, various fabrication methods, involving some innovative techniques utilizing standing‐wave optics, UV dual photopolymerization, and inkjet printing, are succinctly summarized for constructing different photonic structures by using diverse building materials. Subsequently, some typical application examples of 1D photonic materials are listed and discussed involving visual sensing, intelligent displays, anti‐counterfeiting technology, photonic pigments, and optical devices. Finally, the passage addresses the current challenges and presents a forward‐looking perspective on the future fabrication and application of 1DPCs.
A2Pb3[H2N(CH2COO)2]3Cl5 (A = K, Rb): Porous Crystals Constructed on [Pb3Cl5O6] Clusters with Comprehensive Nonlinear Optical Performance
Authors: Zhu Yahui , Ma Zuju , Li Shuangcheng , Geng Zilong , Fu Ruibiao 
Published: March 2024

AbstractNonlinear optical (NLO) crystals that can extend the frequency range of coherent light have significant applications in laser technology, semiconductor manufacturing, and lithography. Herein, two interesting NLO crystals, A2Pb3[H2N(CH2COO)2]3Cl5 (A = K, Rb), are rationally obtained. Their porous structures are constructed on [Pb3Cl5O6] clusters that possess large hyperpolarizability and polarizability anisotropy, and are arranged in a parallel manner. Remarkably, A2Pb3[H2N(CH2COO)2]3Cl5 (A = K, Rb) exhibits comprehensive NLO performance, including strong phase‐matching second‐harmonic generation (SHG) response, the widest bandgap among lead oxychloride NLO crystals, larger laser damage threshold than 127 MW cm−2, suitable birefringence of 0.11@1064 nm, high thermal stability, non‐deliquescence, as well as facile crystal growth. Theoretical calculations and structural analysis demonstrate that their strong SHG response is predominantly originated from the [Pb3Cl5O6] cluster. This study will provide a unique method for the discovery of new interesting NLO crystals in future.
Aspirin‐Mediated Acetylation of SIRT1 Maintains Intestinal Immune Homeostasis
Authors: Xie Liangguo , Li Chaoqun , Wang Chao , Wu Zhen , Wang Changchun , Chen Chunyu , Chen Xiaojian , Zhou Dejian , Zhou Qiang , Lu Ping , Ding Chen , Liu Chen‐Ying , Lin Jinzhong , Zhang Xumin , Yu Xiaofei , Yu Wei 
Published: March 2024

AbstractAspirin, also named acetylsalicylate, can directly acetylate the side‐chain of lysine in protein, which leads to the possibility of unexplained drug effects. Here, the study used isotopic‐labeling aspirin‐d3 with mass spectrometry analysis to discover that aspirin directly acetylates 10 HDACs proteins, including SIRT1, the most studied NAD+‐dependent deacetylase. SIRT1 is also acetylated by aspirin in vitro. It is also identified that aspirin directly acetylates lysine 408 of SIRT1, which abolishes SIRT1 deacetylation activity by impairing the substrates binding affinity. Interestingly, the lysine 408 of SIRT1 can be acetylated by CBP acetyltransferase in cells without aspirin supplement. Aspirin can inhibit SIRT1 to increase the levels of acetylated p53 and promote p53‐dependent apoptosis. Moreover, the knock‐in mice of the acetylation‐mimic mutant of SIRT1 show the decreased production of pro‐inflammatory cytokines and maintain intestinal immune homeostasis. The study indicates the importance of the acetylated internal functional site of SIRT1 in maintaining intestinal immune homeostasis.