bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prognostic value of preoperative D-dimer to albumin ratio for overall survival and progression-free survival in colorectal cancer
Authors: Wei Lishuang , Xie Hailun , Wang Qiwen , Tang Shuangyi , Gan Jialiang 
Published: February 2024

Introduction: This study aimed to explore the predictive value of the D-dimer-to-albumin ratio (DAR) for progression-free survival (PFS) and overall survival (OS) in patients with colorectal cancer (CRC).Methods: The Kaplan-Meier method was used to plot survival curves for PFS and OS. Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive efficacy of the DAR for PFS and OS in patients with CRC. Cox proportional hazards regression analysis was used to analyze prognostic factors influencing outcomes. A nomogram based on the DAR was constructed to predict 1-, 3-, and 5-year prognoses of patients with CRC; its predictive ability was evaluated using the concordance index (C-index) and calibration curves. Additionally, the clinical utility of the DAR-based nomogram was validated using an internal randomized validation cohort.Results: A total of 1,339 patients with CRC who underwent surgery were enrolled. The optimal cut-off value for DAR was determined to be 3.320, dividing patients into low (&lt;3.320 [n = 470]) and high (≥3.320 [n = 869]) DAR groups. Compared with other composite immune inflammatory markers, DAR exhibited superior prognostic predictive efficacy. Patients with a high DAR had a significantly worse prognosis than those with a low DAR (PFS, 50.9% versus [vs.] 69.4%, p &lt; 0.001; OS, 52.9% vs. 73.8%, p &lt; 0.001). DAR also demonstrated significant prognostic stratification for most tumor subgroups, particularly in the stage III-IV subgroup and normal carcinoembryonic antigen subgroup. DAR has been identified as an independent predictive indicator of PFS/OS in patients with CRC. For every standard deviation increase in DAR, the risk for PFS/OS in patients with CRC was reduced by 9.5% (hazard ratio [HR] 1.095 [95% confidence interval (CI) 1.013–1.185]; p = 0.022) and 9.3% (HR 1.093 [95% CI 1.012–1.180]; p = 0.024), respectively. The DAR-based nomogram was confirmed to demonstrate good prognostic prediction accuracy and achieved high evaluation in the internal validation cohort.Conclusion: Preoperative DAR is a promising biomarker for predicting PFS and OS among patients with CRC. The DAR-based prognostic prediction nomogram may serve as an effective tool for the comprehensive assessment of prognosis in patients with CRC.
Epistasis in neurotransmitter receptors linked to posttraumatic stress disorder and major depressive disorder comorbidity in traumatized Chinese
Authors: Xu Ling , Zhang Jingyi , Yang Haibo , Cao Chengqi , Fang Ruojiao , Liu Ping , Luo Shu , Wang Binbin , Zhang Kunlin , Wang Li 
Published: February 2024

BackgroundPosttraumatic stress disorder (PTSD) and major depressive disorder (MDD) comorbidity occurs through exposure to trauma with genetic susceptibility. Neuropeptide-Y (NPY) and dopamine are neurotransmitters associated with anxiety and stress-related psychiatry through receptors. We attempted to explore the genetic association between two neurotransmitter receptor systems and the PTSD–MDD comorbidity.MethodsFour groups were identified using latent profile analysis (LPA) to examine the patterns of PTSD and MDD comorbidity among survivors exposed to earthquake-related trauma: low symptoms, predominantly depression, predominantly PTSD, and PTSD–MDD comorbidity. NPY2R (rs4425326), NPY5R (rs11724320), DRD2 (rs1079597), and DRD3 (rs6280) were genotyped from 1,140 Chinese participants exposed to earthquake-related trauma. Main, gene–environment interaction (G × E), and gene–gene interaction (G × G) effects for low symptoms, predominantly depression, and predominantly PTSD were tested using a multinomial logistic model with PTSD–MDD comorbidity as a reference.ResultsThe results demonstrated that compared to PTSD–MDD comorbidity, epistasis (G × G) NPY2R-DRD2 (rs4425326 × rs1079597) affects low symptoms (β = −0.66, OR = 0.52 [95% CI: 0.32–0.84], p = 0.008, pperm = 0.008) and predominantly PTSD (β = −0.56, OR = 0.57 [95% CI: 0.34–0.97], p = 0.037, pperm = 0.039), while NPY2R-DRD3 (rs4425326 × rs6280) impacts low symptoms (β = 0.82, OR = 2.27 [95% CI: 1.26–4.10], p = 0.006, pperm = 0.005) and predominantly depression (β = 1.08, R = 2.95 [95% CI: 1.55–5.62], p = 0.001, pperm = 0.001). The two G × G effects are independent.ConclusionNPY and dopamine receptor genes are related to the genetic etiology of PTSD–MDD comorbidity, whose specific mechanisms can be studied at multiple levels.
Dietary pyrroloquinoline quinone hinders aging progression in male mice and D-galactose-induced cells
Authors: Mohamad Ishak Nur Syafiqah , Kikuchi Midori , Ikemoto Kazuto 
Published: February 2024

Background: Understanding and promoting healthy aging has become a necessity in the modern world, where life expectancy is rising. The prospective benefits of the antioxidant pyrroloquinoline quinone (PQQ) in healthy aging are promising. However, its role in aging remains unclear. Thus, this study aimed to investigate the effect of PQQ on preventing the progression of aging and to explore its underlying molecular mechanisms.Methods: Naturally aged C57BL/6J male mice were fed a normal diet with or without PQQ (20 mg/kg/day) for 10 weeks. Body composition was measured by bioimpedance at weeks 0 and 8. The integument conditions were evaluated at weeks 0, 4, and 8. Muscle strength and function were examined at week 8. At the ninth week, computed tomography images of the mice were captured, and blood and tissue samples were collected. The levels of inflammatory cytokines in the gastrocnemius muscle were measured, and the muscle fiber cross-sectional area in the soleus muscle was examined. Additionally, a D-galactose (D-gal)-induced cell aging model was used to study the effects of PQQ intervention on cell proliferation, senescence, differentiation, ROS levels, and mitochondrial function in myoblasts (C2C12). Cell proliferation and monolayer permeability of D-gal-induced intestinal epithelial cells (IEC6) were also examined.Results: Aged mice suffered from malnutrition; however, PQQ supplementation ameliorated this effect, possibly by improving metabolic dysfunction and small intestinal performance. PQQ prevented rapid loss of body fat and body fluid accumulation, attenuated muscle atrophy and weakening, reduced chronic inflammation in skeletal muscles, and improved skin and coating conditions in aged mice. Furthermore, PQQ intervention in D-gal-treated C2C12 cells improved mitochondrial function, reduced cellular reactive oxygen species (ROS) levels and senescence, and enhanced cell differentiation, consequently preventing age-related muscle atrophy. In addition, PQQ increased cell proliferation in D-gal-treated IEC6 cells and consequently improved intestinal barrier function.Conclusion: PQQ could hinder the aging process and particularly attenuate muscle atrophy, and muscle weakness by improving mitochondrial function, leading to reduced age-related oxidative stress and inflammation in muscles. PQQ may also ameliorate malnutrition caused by intestinal barrier dysfunction by enhancing IEC proliferation. This study provides evidence for the role of PQQ in aging and suggests that PQQ may be a potential nutritional supplementation that can be included in healthy aging strategies.
Impact of the COVID-19 pandemic and COVID vaccination campaign on imaging case volumes and medicolegal aspects
Authors: Battaglia Caterina , Manti Francesco , Mazzuca Daniela , Cutruzzolà Antonio , Corte Marcello Della , Caputo Fiorella , Gratteri Santo , Laganà Domenico 
Published: February 2024

PurposeThe coronavirus pandemic (COVID-19) significantly impacted the global economy and health. Italy was one of the first and most affected countries. The objective of our study was to assess the impact of the pandemic and the vaccination campaign on the radiological examinations performed in a radiology department of a tertiary center in Southern Italy.Materials and methodsWe analyzed weekly and retrospectively electronic medical records of case volumes performed at the Radiology Department of “Mater Domini” University Hospital of Catanzaro from March 2020 to March 2022, comparing them with the volumes in the same period of the year 2019. We considered the origin of patients (outpatient, inpatient) and the type of examinations carried out (x-ray, mammography, CT, MRI, and ultrasound). A non-parametric test (Wilcoxon Signed Rank test) was applied to evaluate the average volumes.ResultsTotal flows in the pandemic period from COVID-19 were lower than in the same pre-pandemic period with values of 552 (120) vs. 427 (149) median (IQR) (p &lt; 0.001). The vaccination campaign allowed the resumption of the pre-vaccination pandemic with total flows 563 (113) vs. 427 (149) median (IQR) p &lt; 0.001. In the post-vaccination period, the number of examinations was found to overlap with the pre-COVID period.ConclusionThe pandemic impacted the volume of radiological examinations performed, particularly with the reduction of tests in outpatients. The vaccination allowed the return to the pre-COVID period imaging case volumes.
Continuous inline monitoring of glucose in an organ-on-chip using FreeStyle™ libre glucometers
Authors: Sánchez-Salazar Mónica Gabriela , Garza-Garza Regina , Crespo-López Oliver Regina , Jerezano-Flores Valeri Sofía , Gallegos-Martínez Salvador , Ramos-Meizoso Sofía , Verduzco-Valenzuela Manuel , Trujillo-de Santiago Grissel , Alvarez Mario Moisés 
Published: February 2024

Introduction: Organ-on-chips have become an effective platform for studying the physiology of tissues and organs and for evaluating the safety and efficacy of drugs. In these systems, the inline monitoring of key parameters of biological performance (i.e., glucose, oxygen, or lactic acid concentrations) provides valuable information regarding the cell/tissue physiological state. However, significant limitations still exist when attempting to obtain inline information in these systems, and the microsensing technology of on-chip measurement of key parameters is still limited by size, cost, and availability.Methods: Here, we demonstrate the use of a commercially available glucometer (FreestleTM Libre; Abbott), normally used for continuous determination of blood glucose levels, to provide continuous inline measurements of the glucose concentration in tumor-on-chips. Here, we employed a colorectal tumor-on-chip as a first demonstration model and measured the on-chip concentration of glucose continuously for extended culture times (2 weeks).Results and Discussion: We show that inline glucose readings are reproducible and enable the accurate determination of glucose consumption rates (GCRs) by a tumor cell culture. In turn, the GCR measurements provide valuable information regarding the changes in the metabolic activity of the on-chip cultures following inlet perturbations (i.e., delivery of pulses of glucose, culture media additives, and drugs). Inline continuous glucose sensors will be useful tools in organ-on-chip research and will greatly enable cancer research in tumor-on-chip systems.
First Use of Free-Diving Photo-Identification of Porbeagle Shark (Lamna nasus) off the Brittany Coast, France
Authors: Jung Armelle , Ory Arthur , Abaut Paul , Zaccagnini Lucas 
Published: February 2024

A large number of pelagic shark species have declined significantly in recent decades due to overfishing, bycatch, and habitat degradation. Whereas porbeagle sharks have become scarce due to a reduction in their populations around the world, recent stock evaluations are giving positive signals about the evolution of the North-Eastern Atlantic stock size. The porbeagle shark (Lamna nasus), an offshore pelagic species with a wide distribution, is designated by IUCN as Globally Vulnerable and Critically Endangered for Europe and subject to various international conservation conventions. An increasing number of observations are reported off the Brittany coast of Trégor. The ecological role of this area for the species is still unknown and greater knowledge is needed to develop and apply sustainable management measures on a local and international scale. This study represents the first use of photo-identification on porbeagle sharks in order to improve the ecological knowledge of the species in the Trégor area. These results confirm the effectiveness of this method, with 19 of the 131 individuals identified being re-sighted, indicating an interesting degree of site fidelity and showing a sex ratio of 100% females. Observations of individuals over several years allowed the researchers to discuss the relevance of the different types of marks. The findings suggest that the Trégor area off the Brittany coast serves as a seasonal residence for female porbeagle sharks, especially between May and October. This study represents a successful first step in the use of photo-identification for this species. It offers technical support for the sharing of the methodology and provides some biological knowledge allowing researchers to discuss potential sustainable management measures for the conservation of porbeagle sharks in the study area and their habitats while needed.
Comprehensive Analysis of 11 Species of Euodia (Rutaceae) by Untargeted LC-IT-TOF/MS Metabolomics and In Vitro Functional Methods
Authors: Yong Xuhong , Wang Bi , Wang Mengdi , Lyu Hui , Yin Min , Jin Tong , Feng Xu , Shan Yu , Liang Yan , Wang Qizhi 
Published: February 2024

The Euodia genus comprises numerous untapped medicinal plants that warrant thorough evaluation for their potential as valuable natural sources of herbal medicine or food flavorings. In this study, untargeted metabolomics and in vitro functional methods were employed to analyze fruit extracts from 11 significant species of the Euodia genus. An investigation of the distribution of metabolites (quinolone and indole quinazoline alkaloids) in these species indicated that E. rutaecarpa (Euodia rutaecarpa) was the most widely distributed species, followed by E. compacta (Euodia compacta), E. glabrifolia (Euodia glabrifolia), E. austrosinensis (Euodia austrosinensis), and E. fargesii (Euodia fargesii). There have been reports on the close correlation between indole quinazoline alkaloids and their anti-tumor activity, especially in E. rutaecarpa fruits which exhibit effectiveness against various types of cancer, such as SGC-7901, Hela, A549, and other cancer cell lines. Additionally, the E. rutaecarpa plant contains indole quinazoline alkaloids, which possess remarkable antibacterial properties. Our results offer novel insights into the utilization of Euodia resources in the pharmaceutical industry.
Identification of compressive strain in thin ferroelectric Al1–x
Sc
x
N films by Raman spectroscopy
Authors: Tokita Yukimura , Hoshii Takuya , Wakabayashi Hitoshi , Tsutsui Kazuo , Kakushima Kuniyuki 
Published: February 2024

Abstract
Compressive strain in thin ferroelectric Al1–x
Sc
x
N films with different Sc atom concentrations (x) on sapphire substrates was identified by Raman spectroscopy measurement. Both E2
H and A1(LO) spectra showed a blue shift while thinning the Al1–x
Sc
x
N film thicknesses. The shift was enhanced with higher Sc atom concentration. A stress of the order of 200 MPa was applied from the substrate interface, resulting in a strain of the order of 10−4. The presence of the compressive strain at the bottom interface can be correlated to the increase in the coercive field for thinner Al1–x
Sc
x
N films.
Dynamic characteristics and deep reinforcement learning of proportional-integral-differential controller for quadruped stator-based ultrasonic linear motor
Authors: Jiang Yukun , Wang Fangyi , Sasamura Tatsuki , Mustafa Abdullah , Morita Takeshi 
Published: February 2024

Abstract
Ultrasonic linear motors have many advantages, such as small size, light weight, and a lack of electromagnetic interference. In our previous study, a quadruped stator-based ultrasonic linear motor that mimics the motion of an inchworm based on longitudinal and bending modes was proposed. However, our previous studies focused on voltage control, overlooking the influence of phase, which made accurate and sustainable operation difficult. This study measures the dynamic characteristics of this motor using polymer-based rods and combines deep reinforcement learning (DRL) with proportional-integral-differential (PID) algorithms for both position and speed control through phase manipulation. The proposed DRL-PID controller outperforms voltage control in both simulation and real-world experiments.
Investigation of single-particle detection of continuous-wave coherent Doppler lidar: theoretical feasibility and performance comparison with multiple-particle detection state
Authors: Kameyama Shumpei 
Published: February 2024

Abstract
Single-particle detection with a continuous-wave coherent Doppler lidar (CW-CDL) is an interesting event. Even though some experimental results have been shown in previous literature as evidence of single-particle detection, these results have not been verified from a theoretical point of view. Here, the performance of a CW-CDL with single-particle detection is investigated. Examples of single-particle detection that have been reported in previous literature are verified using theoretical simulation. Furthermore, comparison of signal detection ability between single- and multiple-particle cases is also performed theoretically.
Significant reduction in sidewall damage related external quantum efficiency (EQE) drop in red InGaN microLEDs (∼625 nm at 1 A cm−2) with device sizes down to 3 μm
Authors: Sanyal Surjava , Lin Qinchen , Shih Timothy , Zhang Shijie , Wang Guangying , Mukhopadhyay Swarnav , Vigen Jonathan , Zhang Wentao , Pasayat Shubhra S. , Gupta Chirag 
Published: February 2024

Abstract
Ultra-small (10 μm) InGaN-based red microLEDs (625 nm at 1 A cm−2) are necessary for modern displays. However, an increase in surface-area-to-volume ratio with a decrease in the micro-LED size resulting in higher surface recombination causes a drop in efficiency with device size. In this letter, we demonstrate microLEDs from 60 μm down to 3 μm with significantly reduced sidewall-related efficiency reduction using a two-step passivation technique using Al2O3 and Si3N4. The peak on-wafer EQE changes from 0.21% to 0.35% as the device size reduces from 60 to 3 μm, possibly due to improved light extraction efficiency for smaller mesa-widths.
Russian fishing in the Atlantic and Southeastern Pacific Oceans in 2000–2020
Authors: Bandurin Konstantin V. , Khlivnoy Vladimir  N. , Grekov A. A. , Prozorkevich Dmitry V. , Maslyankin Grigoriy E. , Timoshenko Nikolay M. , Kasatkina Svetlana M. , Nesterov Alexander  A. , Gulyugin Sergey Y. , Leontiev Sergej Yu. 
Published: February 2024

The aim: to analyze the development of domestic fisheries in the Atlantic and Southeastern Pacific Oceans in 2000–2020, to assess the state of stocks and catch of the most important types of aquatic biological resources.Methods: conducting trawl-a coustic, ichthyological and hydrological accounting studies in 2000–2020. Analysis of domestic and foreign literature.Novelty: the article presents an up-to-date analysis of the development of Russian fishing, the intensity of fishing and the state of exploited stocks of commercial fish species.Results: Information is provided on the status and dynamics of stocks and catch of commercial aquatic organisms in various areas of the Atlantic and southeastern Pacific Ocean. During the period under review, the highest biomass of stocks and catch are observed in pelagic fish species in the North-East Atlantic. The state of stocks and catch of bottom fish species in the far North Atlantic regions are at an average or low level. In general, in the first two decades of the XXI century, favorable conditions for conducting domestic fishing were noted. For the Central-Eastern Atlantic area (EEZ of Morocco and Mauritania), information is provided on the status of the main commercial fish stocks. Particular attention was paid to the possibility of resuming the domestic tuna and mackerel fishery in the south-e astern Pacific Ocean.Practical significance: the results of the analysis can be used to make management decisions on the development and regulation of fishing.
Hubungan Kelekatan Teman Sebaya Dengan Kematangan Sosial pada Remaja Akhir
Authors: Ramida U  , Sakti Pratiwi 
Published: February 2024

Tujuan dalam penelitian ini yaitu untuk mengetahui “hubungan kelekatan teman sebaya dengan kematangan sosial pada remaja akhir di Asrama Universitas Teknologi Sumbawa. Penelitian ini menggunakan pendekatan kuantitatif deskriptif. Teknik Pengambilan sampel penelitian menggunakan karakteristik dengan penentuan jumlah sampel menggunakan tabel krejcie. Sampel dalam penelitian ini berjumlah 73 remaja akhir putri. Data penelitian diperoleh dengan menggunakan instrumen penelitian berupa dua skala yaitu skala kelekatan teman sebaya dan kematangan sosial. Hasil penelitian ini menunjukan bahwa adanya hubungan (korelasi) positif dan signifikan antara kelekatan aman dan kematangan sosial dengan nilai koefisien korelasi sebesar 0,112 dengan nilai p hitung = 0,345 / p< 0,05 yang berarti semakin tinggi kelekatan teman sebaya remaja akhir, maka kematangan sosial remaja akhir, begitupun sebaliknya. Semakin rendah kelekatan teman sebaya remaja akhir, maka semakin rendah kematangan sosial remaja akhir.
Hubungan Antara Sensation Seeking Dengan Konformitas Pada Pendaki Gunung Di Kota X
Authors: Insan Imammul , Chaeru Jihad Moh , Hakim Lukmanul 
Published: February 2024

Tujuan penelitian yakni untuk mengetahui hubungan antara sensation seeking dengan konformitas pada pendaki gunung di kota X. Penelitian ini menggunakan pendekatan kuantitatif korelasional. Teknik pengambilan sampel penelitian menggunakan total sampling sebanyak 73 sampel. Instrumen penelitian yakni dua skala psikologi yaitu skala sensation seeking dan konformitas. Hasil penelitian menunjukkan bahwa adanya hubungan positif antara sensation seeking dengan konformitas, variabel sensation seeking dapat memberikan hubungan yang signifikan dengan variabel konformitas pada pendaki gunung di kota X, dengan nilai p hitung = 0,045/ (p<0,05). Hubungan positif menunjukkan bahwa hubungan yang terjadi bersifat searah, yang berarti semakin tinggi sensation seeking seorang pendaki gunung, maka semakin tinggi pula konformitas yang dimiliki seorang pendaki gunung. Dan sebaliknya, semakin rendah sensation seeking seorang pendaki gunung, maka semakin rendah konformitas yang dimiliki seorang pendaki gunung. Tetapi nilai koefisien korelasi sebesar 0,236 masuk kategori rendah, artinya variabel sensation seeking belum menjadi variabel inti yang berkorelasi kuat dengan variabel konformitas.
Hubungan Hubungan Kecanduan Penggunaan Media Sosial Dengan Kualitas Tidur Pada Mahasiswa Keperawatan Magelang Poltekkes Kemenkes Semarang
Authors: Firdaus Naufal , Sunarko  , Sugiarto Angga , Suharsono  
Published: February 2024

Penelitian ini bertujuan untuk mengetahui hubungan antara kecanduan penggunaan media sosial dengan kualitas tidur. Penelitian ini menggunakan desain penelitian observasional analitik dengan pendekatan cross-sectional. Teknik pengambilan sampel menggunakan simple random sampling dengan jumlah responden 185 mahasiswa yang memenuhi kriteria inklusi dan eksklusi. Alat ukur penelitian ini menggunakan bergen social media addiction scale dan pittsburgh sleep quality index. Hasil penelitian menunjukkan sebanyak 73% responden mengalami kecanduan penggunaan media sosial tingkat sedang dan 75,7% responden mengalami kualitas tidur buruk. Hasil analisis bivariat dengan menggunakan somers’d menunjukkan bahwa nilai signifikansi (p) = 0.001 (p<0,05) yang berarti terdapat hubungan antara kecanduan penggunaan media sosial dengan kualitas tidur. Hubungan positif manandakan bahwa semakin tinggi tingkat kecanduan penggunaan media sosial maka semakin buruk kualitas tidur pada mahasiswa. Sebaliknya, semakin rendah tingkat kecanduan penggunaan media sosial, maka semakin baik kualitas tidur mahasiswa.