bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zinc finger protein 639 expression is a novel prognostic determinant in breast cancer
Authors: Lee Fang , Cheng Shih-Ping , Chen Ming-Jen , Huang Wen‐Chien , Liu Yi-Min , Chang Shao-Chiang , chang yuan-ching 
Published: April 2024

Abstract

Background: ZNF639 is often contained within the overlapping amplicon of PIK3CA, and previous studies suggest that it was involved in the pathogenesis of esophageal and oral squamous cell carcinomas. However, its expression and significance in breast cancer remain uncharacterized.
Methods: Immunohistochemical analysis of ZNF639 was performed on our tissue microarrays. Functional studies including colony formation, transwell cell migration, and in vivo metastasis were performed in breast tumor cells with ZNF639 knockdown by siRNA transfection.
Results: Reduced ZNF639 immunoreactivity was observed in 82% of breast cancer samples independent of hormone receptor and HER2 status. In multivariate Cox regression analyses, ZNF639 expression was negatively associated with recurrence-free survival (hazard ratio = 0.36) and marginally with overall survival (hazard ratio = 0.42). ZNF639 knockdown increased clonogenicity, cell motility, and murine lung metastasis. Snail1, vimentin, and CCL20 expression were upregulated following ZNF639 knockdown, and ZNF639-mediated changes in cell phenotype were neutralized by CCL20 double-knockdown.
Conclusion: Low ZNF639 expression represents a novel prognostic factor for recurrence-free survival in patients with breast cancer.
Comparison of the lumbar drain and the hydroxyapatite methods for cerebrospinal fluid leakage after endoscopic skull base surgery
Authors: Yang Minho , Kim Gung Ju , Jeon Juhee , Byeon Yukyeng , Lee Chaejin , Kim Ji Heui , Song Sang Woo , Hong Chang-Ki , Kim Jeong Hoon , Kim Yong Hwy , Kong Doo-Sik , Kim Young-Hoon 
Published: April 2024

Abstract

This study aimed to compare the clinical outcomes and risk of two skull base reconstruction methods after expanded endoscopic skull base approach (EEA), viz. postoperative cerebrospinal fluid (CSF) lumbar drainage (L-method) and injectable hydroxyapatite cement without lumbar drainage (H-method).
We enrolled 211 consecutive patients with grade 2 or 3 CSF leakage after EEA. The most common preoperative diagnoses were pituitary adenoma (n=62, 29%), meningioma (n=50, 24%), and craniopharyngioma (n=28, 13%). Vascularized nasoseptal flaps were used in most cases (98%). We used the L-method and H-method in 83 (39%) and 103 patients (49%), respectively.
The overall reconstruction-related complication and CSF leakage rates were 8% (18/211) and 6% (12/211), respectively. The complications included CSF leakage (n=12), infection (n=4), postoperative compression (n=2), and brain herniation (n=1). The complication and CSF leakage rates did not differ significantly between the L-method (12% and 10%, respectively) and H-method (8% and 4%, respectively) (P=0.326 and 0.112, respectively). All infections occurred in the H-method (P=0.070). Postoperative hospital stay was significantly shorter with the H-method (6.9 days) compared to the L-method (10.0 days) (p<0.001).
Skull base reconstruction using hydroxyapatite effectively prevented CSF leakage and ensured patient comfort and shorter hospitalization without postoperative lumbar drainage, although postoperative infection requires consideration.
Optimization of influencing factors for determination of contact angle of mineral powder by column wick method
Authors: Zhang yan , Zang Wenke , Cao Shenyang , Li Bo , Yi Zhao , Sun Mengkai , Dong Yuanshuai , Zhang Ying , Zhang Guoke , Song Shanglin 
Published: April 2024

Abstract

The contact angle is the most important parameter in the application of SFE theory (a reliable method to evaluate water damage of asphalt mixture). The column wick method is an efficient and reliable method for measuring the contact angle of mineral powders, if the measurement steps are standardized. This paper optimized the parameters that can affect the contact angle measurement by the column wick method to solve the problem of poor reproducibility of experimental results due to the non-standardization of the measurement steps. Firstly, a set of column wick method apparatus was developed to ensure the accuracy and consistency of the measurement. Secondly, there were some factors selected as the influencing factors of the contact angle measurement results, such as particle size of aggregate powder, vibration time, different polarity impregnation solution and aggregate acidity and alkalinity. The vibration time affected the density of the mineral powder, the particle size affected the effective particle size, and the capillary permeability, on the other hand, was affected by the acidity and alkalinity of the aggregate and the different polarity of the impregnating solution. Finally, the results of measuring the contact angle of the same type aggregate by column wick method and sessile drop method were compared. The results showed that when the contact angle of the aggregate was measured by the column wick method, the best contact angle was obtained when the particle size was 0.04-0.075 mm, the vibration time of the mineral powder was 6 minutes. Chloroform, diiodomethane and formamide were used as impregnating liquids, with a maximum error of only 16.97°, which is only 0.34 times that (49.26°) of the sessile drop method. Through optimization, the column wick method measured the contact angle with high accuracy and reproducibility.
Reparative Effects of Schizophyllum commune Oat Bran Fermentation Broth on UVB-induced Skin Inflammation via the JAK/STAT Pathway
Authors: Song Zixin , Geng Jiman , Wang Dongdong , Fang Jiaxuan , Wang Ziwen , Wang Changtao , Li Meng 
Published: April 2024

Abstract

Human immortal keratinocyte cells (HaCaT) are induced with UVB to establish an injury model, which is used as the basis to investigate whether oat bran fermentation broth (OBF) has reparative effect on skin inflammation and damage to the skin barrier due to UVB irradiation. The results show that compared with unfermented oat bran (OB), OBF has higher structural homogeneity, and increased molecular weight size, active substances content and in vitro antioxidant activity. OBF has a scavenging effect on excess ROS and increases the intracellular levels of antioxidant enzymes. In addition, it was found that OBF has a stronger inhibitory effect on the release of inflammatory factors than OB, and increase the synthesis of AQP3 and FLG proteins, and decrease the secretion of KLK-7. OBF can inhibit the transcription level of inflammatory factors by inhibiting the JAK/STAT signaling pathway. Safety experiments show that OBF has a high safety profile.
Evaluation of emissions and performance of a diesel engine running on graphene nanopowder and diesel-biodiesel-ethanol blends
Authors: Noorollahi Yaser , -Ardeh Ezzatollah Askari Asli , Jahanbakhshi Ahmad , Khodayari Ali , Gorjian Shiva 
Published: April 2024

Abstract

Today, there are environmental problems all over the world due to the emission of greenhouse gasses caused by the combustion of diesel fuel. The excessive consumption and drastic reduction of fossil fuels have prompted the leaders of various countries, including Iran, to put the use of alternative and clean energy sources on the agenda. In recent years, the use of biofuels and the addition of nanoparticles to diesel fuel have reduced pollutant emissions, improved the environment and enhanced the physicochemical properties of the fuel. The current research deals with the experimental evaluation of emissions and performance of a diesel engine running on graphene nanopowder together with diesel-biodiesel-ethanol blends. The engine variables studied included the engine speed (in three stages: 1800, 2200 and 2600 rpm) and three types of fuel including graphene nanoparticles (with values of 25 and 50 ppm), biodiesel (with volume percentages of 4, 6 and 8) and ethanol (with volume percentages of 2 and 4). The results showed that the power and torque of the D86 + B8 + E6 + G50 fuel increased on average by 20.26% and 28.76% at all engine speeds compared to the D100 fuel. The use of D86 + B8 + E6 + G50 fuel resulted in a significant reduction in CO (38.84%), UHC (21.24%) and NOx (19.92%) emissions compared to D100 fuel. In addition, a significant increase in CO2 emissions (23.19%) was observed. The results of this study clearly show that the use of biofuels and the addition of nanopowder to D100 fuel is a very effective method to improve combustion, performance and emission characteristics in diesel engines.
PT-symmetric KdV Solutions and Their Algebraic Extension with Zero-Width Resonances
Authors: Abhinav Kumar , Shukla Aradhya , Panigrahi Prasanta Kumar 
Published: April 2024

Abstract
A class of complex breather and soliton solutions to both KdV and mKdV equations are identified with a Pöschl-Teller type PT-symmetric potential. However, these solutions represent only the unbroken-PT phase owing to their isospectrality to an infinite potential well in the complex plane having real spectra. To obtain the broken-PT phase, an extension of the potential satisfying the sl (2,ℝ) potential algebra is mandatory that additionally supports non-trivial zero-width resonances.
Surgical Patients’ Views on Physicians’ Communication Skills in Building Trust: A Cross-sectional Descriptive Study
Authors: Aslan Ahmet , Işık Meryem Türkan , Özdemir Rana Can , Ayaz Merih 
Published: April 2024

Abstract

The objective of the study is to determine the hospitalized surgical patients’ opinions about the communication skills of the physicians in building trust and the factors affecting them. 201 patients staying at the surgical unit constituted the sample of study. The data collection form consisted of demographic data and the Scale of Trust Communication in the Patient-Physician Relationship. Descriptive statistics, Mann-Whitney U, Kruskal-Wallis, Bonferroni correction and Spearman correlation coefficient have been used to analyze the data. The Scale of Trust Communication in the Patient-Physician Relationship total point average was 86.15 ± 10.34. A meaningful relationship was found between the total score and trust in the physician health care attitude, trust in the physician decisions and the patient’s behavior regarding the payment status. The trust communication average score of the patients was high, and the total scale point average increased as the sub-scale averages increased.
Hemagglutinin and neuraminidase of an H7N7 non-pathogenic avian influenza virus coevolved during the acquisition of intranasal pathogenicity in chickens
Authors: Ichikawa Takaya , Hiono Takahiro , Okamatsu Masatoshi , Maruyama Junki , Kobayashi Daiki , Matsuno Keita , Kida Hiroshi , Sakoda Yoshihiro 
Published: April 2024

Abstract

Polybasic amino acid residues at the hemagglutinin (HA) cleavage site are insufficient to induce the highly pathogenic phenotype of avian influenza viruses in chickens. In our previous study, an H7N7 avian influenza virus named Vac2sub-P0, which is non-pathogenic despite carrying polybasic amino acids at the HA cleavage site, was passaged in chick air sacs and a virus with high intravenous pathogenicity, namely, Vac2sub-P3, was obtained. Intranasal infection with Vac2sub-P3 is only partially lethal in chickens; therefore, in this study, this virus was further passaged in chicken lungs, and the passaged virus, Vac2sub-P3L4, acquired high intranasal pathogenicity. Experimental infection of chickens with recombinant viruses demonstrated that mutations in HA and neuraminidase (NA) found in consecutive passages are responsible for increased pathogenicity. The HA and NA functions of Vac2sub-P3L4 were compared with the parental virus in vitro; the virus growth at 40°C was higher, the binding affinity to a sialic acid receptor was lower, and the release activity by NA from the cell surface was lower, suggesting that these changes enabled the virus to replicate efficiently in chickens with high intranasal pathogenicity. This study critically demonstrated that additional adaptations were required for the highly pathogenic virus via intravenous administration in chickens for increased pathogenicity via intranasal administration.
Fast recovery of North Atlantic sea level in response to atmospheric CO2 removal
Authors: Oh Ji-Hoon , Wang Sunhee , Shin Yechul , Kug Jong-Seong 
Published: April 2024

Abstract

Sea level rise (SLR) due to anthropogenic warming poses substantial threats to coastal environments and human societies. Despite successful climate mitigation efforts, regional reversibility of SLR in response to stabilization or reduction of atmospheric carbon dioxide (CO2) remains unclear. Here, we investigate sea level fluctuations in Subpolar North Atlantic (SPNA) using idealized CO2 ramp-up and -down experiments. We found that during ramp-up period, the SPNA experiences a faster SLR than the global mean, followed by a more rapid decline with decreasing CO2. These dramatic sea level fluctuations are mainly driven by the response of Atlantic Meridional Overturning Circulation (AMOC) to CO2 forcing. The enhanced meridional salinity transport triggered by the rapid AMOC recovery plays a crucial role in the recovery of the SPNA sea level. Our study highlights the potential for abrupt sea level changes in the SPNA and surrounding coastal areas under climate mitigation scenarios.
Influence of social media on intent to undergo cosmetic facial injections among Lebanese university students
Authors: Salameh Rami , Murr Elio El , Ghadban Elie , Hanna Charlie 
Published: April 2024

Abstract

Background With the emergence of social media platforms and accounts advertising for noninvasive cosmetic procedures, obsession with beauty and conforming to certain appearance standards is increasing among adolescents and young adults. The current study aimed to determine whether social media content exposure and other related factors, influence the decision of Lebanese university students to undergo facial cosmetic injections such as dermal fillers and Botox.Methods A cross sectional study was conducted between the first and 20th of august 2023, using an online questionnaire platform on Lebanese university students between the age of 18 and 30. The survey included questions regarding demographic features, facial cosmetic injections, social media use, facial appearance and related psychological distress. A bivariate followed by a multivariate analysis were done. A p-value < 0.05 was considered to be significant.Results A total of 600 responses were collected. Most of who responded were women (N: 398, 66.3%) with a mean age of 22.22+/- 3. Of the participants, 185 (30.8%) considered undergoing facial fillers or Botox injections whereas 31 (5.2%) have already undergone such procedures. Instagram was the platform used the most (N: 466, 77.7%). When considering the multivariate analysis model: being a female, following medical doctors on social media, following cosmetic pages, a personal, family or friend history of undergoing cosmetic facial injections and a bigger engagement on social media platforms as well as low satisfaction with facial appearance were significantly correlated with the intent of undergoing facial dermal fillers and Botox injections. (p = 0.001 < 0.05, OR = 0.393; p = 0.000 < 0.05, OR = 2.847; p = 0.008 < 0.05, OR = 2.034; p = 0.000 < 0.05, OR = 21.066; p = 0.001 < 0.05, OR = 2.371; p = 0.012, OR = 1.419; p = 0.029, OR :0.628 respectively).Conclusion Our study gave a dynamic comprehension about the persuasive effect of social media platforms on Lebanese university students to consider cosmetic facial injections. The significant predictors in our model were related to specific social media behaviors. The study also highlighted the psychological dimension involved in the process, that practitioners should be aware of in their practice.
Artemisinin ameliorates the thyroid function and the complications in adult male hypothyroid rats via upregulating L1 cell adhesion molecule
Authors: Li Lingling , Xu Haifan , Hu Zecheng , Li Li 
Published: April 2024

Abstract

Hypothyroidism, a common worldwide syndrome caused by in sufficient thyroid hormone secretion, affects a good deal of people at different ages. Artemisinin (ART), a well-known effective agent in the treatment of malaria, also owns anti-oxidative stress functions in various diseases. L1 cell adhesion molecule also exerts multiple protective roles in diseased systems. Hence, the aim of this study is to evaluate the role of ART in the in adult male hypothyroid rats and the underlying mechanisms. In the current study, we revealed that, ART can amelioratethe thyroid function, mitigate the depression and anxiety symptoms, attenuate the cognition impairments, improve the liver, kidney and heart functions, and inhibit the oxidative stress, whereas, theses conducive effects exerted by ART cannot be observed when L1 was silenced by L1 siRNA.These combined results indicated that ART can upregulate L1 cell adhesion molecule to ameliorate the thyroid function and the complications in adult male hypothyroid rats, laying the foundation for ART to be a novel strategy for the treatment of hypothyroidism.
Global Research Cooperation Patterns in the Secondary Battery Industry
Authors: AN HOJIN , Cho Keuntae 
Published: April 2024

Abstract
This study aimed to analyze how global research cooperation patterns in the secondary battery industry have changed over recent years and identify the evolution of the research focus in the field. To this end, network analysis was performed using the nationality information of the authors of multinational joint studies related to lithium-ion batteries in the 10-year period 2013–2022. Furthermore, keyword analysis and topic modeling were performed using the studies’ abstract data. According to the results, some countries that are not well-known in the field, such as Australia, Spain, and France, showed high centrality relative to their cooperation levels. Additionally, six research topics were identified. A comparison spanning the first half of the examined decade revealed no differences in the appearance of keywords indicating high energy density and conductivity with lithium, a key mineral. Keyword distribution in the first 5-year period was high for topics such as battery charging and discharging, whereas, in the second half, next-generation battery materials such as solid electrolytes, lithium metal anodes, and lithium-sulfur batteries were frequently occurring. These results provide insights for countries regarding the establishment of research and development cooperation strategies, as well as for companies in the battery industry engaging in pre-planning.
Data-driven identification of a left anterior hippocampus’ morphological network associated with self-regulation
Authors: Balajoo Somayeh Maleki , Plachti Anna , Nicolaisen-Sobesky Eliana , Dong Debo , Hoffstaedter Felix , Meuth Sven , Melzer Nico , Eickhoff Simon , Genon Sarah 
Published: April 2024

Abstract

The human hippocampus is a key region in cognitive and emotional processing, but also a vulnerable and plastic region. Accordingly, there is a great interest in understanding how variability in hippocampus’ structure relates to variability in behavior in healthy and clinical populations. In this study, we aimed to link interindividual variability in subregional hippocampal networks (i.e. the brain grey matter networks of hippocampal subregions) to variability in behavioral phenotype. To do so, we used a multi-block multivariate approach mapping association between grey matter volume in hippocampal subregions, grey matter volume in the whole brain regions and behavioral variables in healthy adults. Implementing this approach in a machine learning framework enabled us to identify stable patterns (latent dimensions) and its application to two large adult datasets further enabled us to focus on a replicable latent dimension that thus captures a general aspect of hippocampal-brain-behavior phenotype in the population. Our results highlighted a left anterior hippocampal morphological network including the left amygdala and the posterior midline structures whose expression relates to higher self-regulation, life satisfaction and better performance at standard neuropsychological tests. Future studies should investigate the structural development of this morphological network across childhood, the genetic and exposome factors influencing it and its relationship to neurocognitive phenotypes in different brain diseases.
Surface Area Outcomes in EUS-Guided Liver Biopsy: A Comparative Study of Franseen and Fork-tip Needles
Authors: Matsumoto Kotaro , Doi Shinpei , Adachi Takako , Watanabe Ayako , Katsukura Nobuhiro , Tsujikawa Takayuki , Aso Tatsuya , Takahashi Mikiko , Kikuchi Kentaro 
Published: April 2024

Abstract

Background/Aims:
The practice of endoscopic ultrasound-guided liver biopsy (EUS-LB) is becoming more common due to its proven safety and effectiveness. For accurate diagnosis, it is vital to secure ample tissue specimens. However, gauging the volume of tissue specimens accurately poses a challenge with existing methods. Additionally, determining the most suitable fine-needle biopsy (FNB) needle requires further study. Our aim was to contrast the tissue surface areas obtained using Franseen and Fork-tip needles and to identify factors affecting tissue volume.
Methods
This retrospective study analyzed liver tissue samples collected through EUS-LB using 19-gauge Franseen and Fork-tip needles from patients suffering from diffuse liver diseases, conducted in our hospital from April 2019 to April 2022. We primarily focused on measuring hepatic tissue surface area and portal tract count, alongside examining patient-related factors that could influence tissue surface area.
Results
The study involved 20 cases for each type of needle. The comparison revealed no significant disparities in the total liver tissue surface area (22.0 mm2 vs. 22.6 mm2, P = 0.45) or in the portal tract counts (30 vs. 20, P = 0.16). No adverse incidents were noted in either group. Both univariate and multivariate analyses highlighted that fibrosis and NAFLD presence were significant determinants of the total hepatic tissue area (P = 0.04, P < 0.05; and P = 0.02, P = 0.03, respectively).
Conclusions
The capabilities of both needles in acquiring liver tissue were comparably effective. The volume of tissue was affected by the severity of fibrosis and the occurrence of NAFLD.