bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of hyperthyroidism and hypothyroidism in liver transplant recipients and associated risk factors
Authors: Suarez-Zdunek Moises Alberto , Arentoft Nicoline Stender , Krohn Paul Suno , Lauridsen Emilie Høegholm Ernst , Afzal Shoaib , Høgh Julie , Thomsen Magda Teresa , Knudsen Andreas Dehlbæk , Nordestgaard Børge Grønne , Hillingsø Jens Georg , Villadsen Gerda Elisabeth , Holland-Fischer Peter , Rasmussen Allan , Fialla Anette Dam , Feldt-Rasmussen Ulla , Nielsen Susanne D. 
Published: April 2024

AbstractThe prevalence of hyperthyroidism and hypothyroidism and associated risk factors are unknown in liver transplant recipients. We aimed to determine the prevalence of hyperthyroidism and hypothyroidism and associated risk factors in liver transplant recipients and to compare it with controls from the general population. As part of the Danish Comorbidity in Liver Transplant Recipients (DACOLT) Study, all Danish liver transplant recipients over the age of 20 were invited for measurements of concentrations of thyrotropin and thyroid hormones. The prevalence of hyperthyroidism and hypothyroidism was compared to age- and sex-matched controls from the Copenhagen General Population Study. Using logistic regression adjusted for age, sex, smoking, and body-mass index, we investigated potential risk factors. We recruited 489 liver transplant recipients and 1808 controls. Among liver transplant recipients, 14 (2.9%) had hyperthyroidism compared with 21 (1.2%) of controls (adjusted odds ratio [aOR] 2.24, 95% confidence interval [CI] 1.05–4.75, P = 0.04), while 42 (5.7%) had hypothyroidism compared with 139 (7.7%) of controls (aOR 0.68, 95% CI 0.43–1.08, P = 0.10). Female sex, and autoimmune hepatitis and primary sclerosing cholangitis as causes of transplantation were associated with hyperthyroidism after adjustments. Age, female sex, and autoimmune liver diseases as cause of transplantation were associated with hypothyroidism after adjustments. DACOLT is registered in ClinicalTrials.gov (NCT04777032).
Neuroprotective role of lactate in a human in vitro model of the ischemic penumbra
Authors: Cerina Marta , Levers Marloes , Keller Jason M. , Frega Monica 
Published: April 2024

AbstractIn patients suffering from cerebral ischemic stroke, there is an urgent need for treatments to protect stressed yet viable brain cells. Recently, treatment strategies that induce neuronal activity have been shown to be neuroprotective. Here, we hypothesized that neuronal activation might maintain or trigger the astrocyte-to-neuron lactate shuttle (ANLS), whereby lactate is released from astrocytes to support the energy requirements of ATP-starved hypoxic neurons, and this leads to the observed neuroprotection. We tested this by using a human cell based in vitro model of the ischemic penumbra and investigating whether lactate might be neuroprotective in this setting. We found that lactate transporters are involved in the neuroprotective effect mediated by neuronal activation. Furthermore, we showed that lactate exogenously administered before hypoxia correlated with neuroprotection in our cellular model. In addition, stimulation of astrocyte with consequent endogenous production of lactate resulted in neuroprotection. To conclude, here we presented evidence that lactate transport into neurons contributes to neuroprotection during hypoxia providing a potential basis for therapeutic approaches in ischemic stroke.
Cyclic CO2 absorption/desorption property of Li3NaSiO4 under the partial pressure of CO2 for practical applications
Authors: Iwasaki Shumpei , Shido Kosuke , Fujishiro Fumito , Hashimoto Takuya 
Published: April 2024

Based on the pseudo van't Hoff plot prepared by thermogravimetry at various P(CO2) values, the cyclic CO2 absorption/desorption property of Li3NaSiO4 was observed at 650 °C under P(CO2) of 0.1 bar.
Inflammatory liver diseases and susceptibility to sepsis
Authors: Lu Hong 
Published: April 2024

Abstract
Patients with inflammatory liver diseases, particularly alcohol-associated liver disease and metabolic dysfunction-associated fatty liver disease (MAFLD), have higher incidence of infections and mortality rate due to sepsis. The current focus in the development of drugs for MAFLD is the resolution of non-alcoholic steatohepatitis and prevention of progression to cirrhosis. In patients with cirrhosis or alcoholic hepatitis, sepsis is a major cause of death. As the metabolic center and a key immune tissue, liver is the guardian, modifier, and target of sepsis. Septic patients with liver dysfunction have the highest mortality rate compared with other organ dysfunctions. In addition to maintaining metabolic homeostasis, the liver produces and secretes hepatokines and acute phase proteins (APPs) essential in tissue protection, immunomodulation, and coagulation. Inflammatory liver diseases cause profound metabolic disorder and impairment of energy metabolism, liver regeneration, and production/secretion of APPs and hepatokines. Herein, the author reviews the roles of (1) disorders in the metabolism of glucose, fatty acids, ketone bodies, and amino acids as well as the clearance of ammonia and lactate in the pathogenesis of inflammatory liver diseases and sepsis; (2) cytokines/chemokines in inflammatory liver diseases and sepsis; (3) APPs and hepatokines in the protection against tissue injury and infections; and (4) major nuclear receptors/signaling pathways underlying the metabolic disorders and tissue injuries as well as the major drug targets for inflammatory liver diseases and sepsis. Approaches that focus on the liver dysfunction and regeneration will not only treat inflammatory liver diseases but also prevent the development of severe infections and sepsis.
Simultaneous NICER and NuSTAR observations of the ultraluminous source NGC 4190 ULX-1
Authors: Combi Jorge A. , Fogantini Federico A. , Saavedra Enzo A. , Romero Gustavo E. , Abaroa Leandro , García Federico , Luque-Escamilla Pedro , Martí Josep , Cruz-Sanchez Nelson 
Published: April 2024

Aims. We present an X-ray analysis of three different XMM-Newton observations together with simultaneous NICER and NuSTAR observations of the ultraluminous X-ray source NGC 4190 ULX-1. Our goal is to constrain the structure of the accretion disk and the geometrical properties of the source.
Methods. We performed temporal and spectral analyses in the 0.4−30 keV energy range in which the source is significantly detected in dedicated XMM-Newton, NICER, and NuSTAR observations.
Results. The temporal analysis shows no flaring activity in the light curves. No pulsation is detected throughout. The source exhibits a typical ULX spectrum, which can be fitted with two thermal blackbody components plus a Comptonization tail at high energies. The luminosity–temperature (L − T) relation of each thermal spectral component is consistent with the L ∝ T2 relation expected from an advection-dominated supercritical disk.
Conclusions. We interpret these results as a super-Eddington accreting black hole seen almost face-on. A dense wind ejected from the disk obscures the central source, and a hot electron plasma is evacuated through the funnel formed above the hole. Geometric beaming is responsible for the ULX soft emission, whereas the hard tail is the result of the Comptonization of soft photons by the electrons ejected through the funnel.
Coupling between magnetic reconnection, energy release, and particle acceleration in the X17.2 2003 October 28 solar flare
Authors: Kurt Victoria G. , Veronig Astrid M. , Fleishman Gregory D. , Hinterreiter Jürgen , Tschernitz Johannes , Lysenko Alexandra L. 
Published: April 2024

Context.The 2003 October 28 (X17.2) eruptive flare was a unique event. The coronal electric field and theπ-decayγ-ray emission flux displayed the highest values ever inferred for solar flares.Aims.Our aim is to reveal physical links between the magnetic reconnection process, energy release, and acceleration of electrons and ions to high energies in the chain of the magnetic energy transformations in the impulsive phase of the solar flare.Methods.The global reconnection rate,φ̇(t), and the local reconnection rate (coronal electric field strength),Ec(r, t), were calculated from flare ribbon separation in Hαfiltergrams and photospheric magnetic field maps. Then, HXRs measured by CORONAS-F/SPR-N and the derivative of the GOES SXR flux,İSXR(t) were used as proxies of the flare energy release evolution. The flare early rise phase, main raise phase, and main energy release phase were defined based on temporal profiles of the above proxies. The available results of INTEGRAL and CORONAS-F/SONG observations were combined with Konus-Wind data to quantify the time behavior of electron and proton acceleration. Promptγ-ray lines and delayed 2.2 MeV line temporal profiles observed with Konus-Wind and INTEGRAL/SPI were used to detect and quantify the nuclei with energies of 10−70 MeV.Results.The magnetic-reconnection rates,φ̇(t) andEc(r, t), follow a common evolutionary pattern with the proxies of the flare energy released into high-energy electrons. The global and local reconnection rates reach their peaks at the end of the main rise phase of the flare. The spectral analysis of the high-energyγ-ray emission revealed a close association between the acceleration process efficiency and the reconnection rates. High-energy bremsstrahlung continuum and narrowγ-ray lines were observed in the main rise phase whenEc(r, t) of the positive (negative) polarity reached values of ∼120 V cm−1(∼80 V cm−1). In the main energy release phase, the upper energy of the bremsstrahlung spectrum was significantly reduced and the pion-decayγ-ray emission appeared abruptly. We discuss the reasons why the change of the acceleration regime occurred along with the large-scale magnetic field restructuration of this flare.Conclusions.The similarities between the proxies of the flare energy release withφ̇(t) andEc(r, t) in the flare’s main rise phase are in accordance with the reconnection models. We argue that the main energy release and proton acceleration up to subrelativistic energies began just when the reconnection rate was going through the maximum, that is, following a major change of the flare topology.
Gestational Age-Specific Markers Associated with Postnatal Intervention in Fetal Suspicion of Coarctation of the Aorta
Authors: Amar Sam , Moore Shiran S. , Wutthigate Punnanee , Ohayon Amanda , Martinez Daniela V. , Simoneau Jessica , Renaud Claudia , Altit Gabriel 
Published: April 2024

Objective Fetal diagnosis of coarctation of the aorta (CoA) is currently associated with a high false-positive rate. Many predictive markers may be gestational age (GA)-specific. We sought to establish GA-specific traditional and speckle-tracking fetal echocardiography (STE) markers predictive of true CoA in neonates with prenatal suspicion.
Study Design This is a retrospective case–control study. We compared the fetal ventricular and arch dimensions, as well as the deformation parameters by STE, of infants who required a postnatal intervention for their CoA with those who did not. Cohort was stratified based on GA before or after 30 weeks. Data extractors were masked to the outcome. The first fetal echocardiogram available was used.
Results Seventy-five newborns with a fetal echocardiography performed between October 2013 and May 2022 for an antenatal suspicion of CoA were included, of which 59 (79%) had an aortic arch with nonsignificant obstruction upon ductal closure, and 16 (21%) underwent a neonatal intervention for a confirmed CoA. Before 30 weeks' GA, the right ventricular to left ventricular (RV/LV) end-diastolic width and end-diastolic area (EDA) ratios were most associated with postnatal CoA confirmation (area under the curve [AUCs] = 0.96 and 0.92). After 30 weeks' GA, the RV/LV end-diastolic width ratio (AUC = 0.95), the Z-score for the ascending aorta (AUC = 0.93), and the LV end-diastolic width Z-score (AUC = 0.91) performed the best. A decreased RV peak longitudinal strain was observed in those who developed true CoA and performed well by receiver operating characteristic analysis after 30 weeks (AUC = 0.85). In the overall cohort, the RV/LV EDA ratio was the most sensitive predictor of CoA and identified all cases with CoA. Indeed, a cutoff > 1.24 had a specificity of 69.5% and a sensitivity of 100% (receiver operating characteristic curve with an AUC of 0.88).
Conclusion We outlined sensitive and specific fetal markers associated with postnatal CoA based on GA at suspicion.
Key Points
Association between SARS-CoV-2 Infection and Adverse Perinatal Outcomes by Race/Ethnicity in a Large Integrated Health Care System
Authors: Mensah Nana A. , Fassett Michael J. , Lurvey Lawrence D. , Oyelese Yinka , Braun David , Sacks David A. , Shi Jiaxiao , Khadka Nehaa , Chiu Vicki Y. , Peltier Morgan R. , Getahun Darios 
Published: April 2024

Objective Recent studies have reported associations between severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection during pregnancy and adverse perinatal outcomes but the extent to which these associations vary by race/ethnicity remains uncertain. Therefore, we examined how the association between prenatal SARS-CoV-2 infection and adverse perinatal outcomes may be modified by race/ethnicity.
Study Design A retrospective cohort study was performed using data on 67,986 pregnant women extracted from the Kaiser Permanente Southern California electronic health records between April 6, 2020, and December 31, 2021. Upon admission to labor and delivery, all women were routinely tested for coronavirus disease 2019 (COVID-19) using real-time reverse-transcriptase polymerase chain reaction test. Adjusted odds ratios (aORs) were used to estimate associations.
Results During the study period, COVID-19 was diagnosed in 4,960 (7%) of singleton pregnancies, with the highest rates observed among Hispanics (9.4%) and non-Hispanic Blacks (6.2%). Compared with non-Hispanic Whites, Hispanics (aOR: 1.12, 95% CI: 1.03, 1.21) with SARS-CoV-2 infection had the highest odds of a pregnancy associated with nonreassuring fetal heart rate tracing. Neonates of all races/ethnicities, except for non-Hispanic Blacks, showed significantly increased odds of SARS-CoV-2 infection, with the highest risk observed among Asians/Pacific Islanders (aOR: 10.88, 95% CI: 1.33, 89.04). Non-Hispanic White mothers who tested positive were admitted to intensive care unit (ICU) at a higher rate at delivery and within 7 days of delivery (aOR: 34.77, 95% CI: 11.3, 107.04; aOR: 26.48, 95% CI: 9.55, 73.46, respectively). Hispanics were also at a significantly higher odds of admission to ICU (aOR: 4.62, 95% CI: 2.69, 7.94; aOR: 4.42, 95% CI: 2.58, 7.56, respectively). Non-Hispanic Black, Hispanic, and Asian/Pacific Islander mothers who tested positive for SARS-CoV-2 prenatally, were at increased risk for preeclampsia/eclampsia, and preterm birth as compared to non-Hispanic White mothers.
Conclusion The findings highlight racial/ethnic disparities in the association between SARS-CoV-2 infection and adverse perinatal outcomes. The risk of neonatal SARS-CoV-2 infection was highest for Asian/Pacific Islanders. We also observed a remarkably high risk of ICU admission for non-Hispanic White mothers infected with SARS-CoV-2.
Key Points
Expectant Management of a Triploid Partial Molar Pregnancy at 26 Weeks' Gestation: A Case Report
Authors: Wong Karen , Ali Mohannad , Stalder Marc , Bonin Brigitte , El-Chaâr Darine 
Published: April 2024

Abstract
Introduction Triploid partial molar pregnancies are not viable, and confer maternal risks including preeclampsia, hemorrhage, gestational trophoblastic neoplasia, and trophoblastic embolization. We report a case managed expectantly until 26 weeks' gestation in a patient requesting continuation of pregnancy.
Case Presentation This G2P1 presented with fetal anomalies indicative of triploid partial molar pregnancy. The pregnancy was complicated by anemia, hyperthyroidism, supraventricular tachycardia, and threatened preterm labor.Her care involved maternal fetal medicine collaborating with internal medicine, palliative care, anesthesia and critical care. Labor was augmented at 26 weeks' gestation, resulting in vaginal delivery. Postpartum course was notably complicated by acute respiratory distress in the immediate postpartum period, which self-resolved. Postpartum hemorrhage and retained products of conception were additional complications.
Conclusion This unique case highlights the role of multidisciplinary collaboration and shared decision making in challenging circumstances.
Clinical Impact of Dyspnea after Ticagrelor Treatment and the Effect of Switching to Clopidogrel in Patients with Myocardial Infarction
Authors: Kim Sang Hyun , Shin Sanghoon , Choo Eun Ho , Choi Ik Jun , Lim Sungmin , Moon Donggyu , Kim Chan Joon , Park Mahn-Won , Kim Min Chul , Hwang Byung-Hee , Lee Kwan Yong , Choi Yun Seok , Kim Hee-Yeol , Yoo Ki-Dong , Jeon Doo Soo , Ahn Youngkeun , Chang Kiyuk ,   on behalf of the TALOS-AMI investigators
Published: April 2024

Background Dyspnea is frequent during ticagrelor-based dual antiplatelet therapy (DAPT) for acute myocardial infarction (AMI). However, its clinical characteristics or management strategy remains uncertain.
Methods The study assessed 2,617 AMI patients from the Ticagrelor versus Clopidogrel in Stabilized Patients with AMI (TALOS-AMI) trial. Dyspnea during 1-month ticagrelor-based DAPT and following DAPT strategies with continued ticagrelor or de-escalation to clopidogrel from 1 to 12 months were evaluated for drug adherence, subsequent dyspnea, major adverse cardiovascular events (MACE), and bleeding events.
Results Dyspnea was reported by 538 patients (20.6%) during 1 month of ticagrelor-based DAPT. Adherence to allocated DAPT over the study period was lower in the continued ticagrelor arm than the de-escalation to clopidogrel, particularly among the dyspneic population (81.1% vs. 91.5%, p < 0.001). Among ticagrelor-treated patients with dyspnea, those switched to clopidogrel at 1 month had a lower frequency of dyspnea at 3 months (34.3% vs. 51.7%, p < 0.001) and 6 months (25.5% vs. 38.4%, p = 0.002) than those continued with ticagrelor. In patients with dyspnea in their 1-month ticagrelor-based DAPT, de-escalation was not associated with increased MACE (1.3% vs. 3.9%, hazard ratio [HR]: 0.31, 95% confidence interval [CI]: 0.08–1.11, p = 0.07) or clinically relevant bleeding (3.2% vs. 6.2%, HR: 0.51, 95% CI: 0.22–1.19, p = 0.12) at 1 year.
Conclusion Dyspnea is a common side effect among ticagrelor-based DAPTs in AMI patients. Switching from ticagrelor to clopidogrel after 1 month in AMI patients may provide a reasonable option to alleviate subsequent dyspnea in ticagrelor-relevant dyspneic patients, without increasing the risk of ischemic events (NCT02018055).
Laboratory-developed Droplet Digital PCR Assay for Quantification of the JAK2V617F Mutation
Authors: Liu Yupeng , Han Cong , Li Jie , Xu Shicai , Xiao Zhijian , Guo Zhiyun , Rao Shuquan , Yao Yao 
Published: April 2024

AbstractPrecise quantification of the JAK2V617F mutation using highly sensitive assays is crucial for diagnosis, treatment process monitoring, and prognostic prediction in myeloproliferative neoplasms' (MPNs) patients. Digital droplet polymerase chain reaction (ddPCR) enables precise quantification of low-level mutations amidst a high percentage of wild type alleles without the need for external calibrators or endogenous controls. The objective of this study was to optimize a ddPCR assay for detecting the JAK2V617F mutation and establish it as a laboratory-developed ddPCR assay in our center. The optimization process involved fine-tuning five key parameters: primer/probe sequences and concentrations, annealing temperature, template amount, and PCR cycles. Our ddPCR assay demonstrated exceptional sensitivity, and the limit of quantification (LoQ) was 0.01% variant allele frequency with a coefficient of variation of approximately 76%. A comparative analysis with quantitative PCR on 39 samples showed excellent consistency (r = 0.988).In summary, through rigorous optimization process and comprehensive analytic performance validation, we have established a highly sensitive and discriminative laboratory-developed ddPCR platform for JAK2V617F detection. This optimized assay holds promise for early detection of minimal residual disease, personalized risk stratification, and potentially more effective treatment strategies in MPN patients and non-MPN populations.
“Because We Are Afraid”: voices of the undocumented in a new immigrant destination in the United States
Authors: Metcalf Madeline , Comey Danika , Hines Deborah , Chavez-Reyes Genesis , Moyce Sally 
Published: April 2024

AbstractThe purpose of this study is to explore immigrants’ perceptions of their daily lives in a state with anti-immigrant policies in the United States. Using snowball sampling, researchers recruited a sample of 30 Latino immigrants in southwest Montana. The research team conducted semi-structured interviews in Spanish and analyzed the data using thematic analysis. We identified four themes: difficulty accessing healthcare, frustration over the inability to obtain driver’s licenses, challenges related to employment, and desire to make a life in Montana. Fear permeated all topics. Lack of documentation presents complex economic, health, and social challenges that prevent immigrants from fully integrating into their communities. These are exacerbated in states that employ anti-immigrant policies. As Western states continue to experience growth in immigrant populations, it is critical to develop policies to support integration and equitable access to health and social services.
Alkali hydroxide (LiOH, NaOH, KOH) in water: Structural and vibrational properties, including neutron scattering results
Authors: Ma Ruru , Baradwaj Nitish , Nomura Ken-ichi , Krishnamoorthy Aravind , Kalia Rajiv K. , Nakano Aiichiro , Vashishta Priya 
Published: April 2024

Structural and vibrational properties of aqueous solutions of alkali hydroxides (LiOH, NaOH, and KOH) are computed using quantum molecular dynamics simulations for solute concentrations ranging between 1 and 10M. Element-resolved partial radial distribution functions, neutron and x-ray structure factors, and angular distribution functions are computed for the three hydroxide solutions as a function of concentration. The vibrational spectra and frequency-dependent conductivity are computed from the Fourier transforms of velocity autocorrelation and current autocorrelation functions. Our results for the structure are validated with the available neutron data for 17M concentration of NaOH in water [Semrouni et al., Phys. Chem. Chem. Phys. 21, 6828 (2019)]. We found that the larger ionic radius [rLi+&lt;rNa+&lt;rK+] and higher concentration disturb the hydrogen-bond network of water, resulting in more disordered cationic hydration shell. Our ab initio simulation data for solute concentrations ranging between 1 and 10M can be used to guide future elastic and inelastic neutron-scattering experiments.