bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Immunological Study on Mucocutaneous Lymph Node Syndrome: Activation of Tg Suppressor Cells
Authors: Matsuoka Yoshiko , Yata Junichi 
Published: October 2007

AbstractWe analyzed the lymphocyte function of MCLS in pokeweed mitogen‐induced immunoglobulin production. T cell suppressor activity was activated in the acute phase adn normalized in convalescence. T cells showing suppressor activity in this system were identified to be Tg cells, and they seemed to be activated as suppressor by a certain factor in the serum. the sera of patients whose T cells showed suppressor activity could induce the suppresoor activity of normal control Tg cells. The suppressor inducing factor in sera is likely to be circulating immune complexes, since Tg cells usually show suppressor activity when they interact with immune complexes. The induction of the suppressor activity of Tg cells by immune complexes may provide a kind of negative feedback suppression mechanism feedback mechanism on the antibody formation and it may be related to the self‐limiting characteristics of MCLS. MCLS is different from collagen diseases such as rheumatoid arthritis in that Tg cells do not usually work as suppressor cells in the later diseases.
Correlation between saliva and serum valproic acid concentrations in epileptic children
Authors: Tokugawa Ken , Ueda Kohji 
Published: October 2007

AbstractThirty‐five epileptic children (13 boys, 22 girls; aged 5 6/12 years to 17 8/12 years) were studied for their saliva and setrum levels of valproic acid (VPA). No obvious correlation between the VPA saliva and serum levels was observed.
Histamine suppression of the non‐immunological release of slow reacting substances from neutrophils of asthmatics
Authors: Torii Shimpei , Kishimoto Machiko , Katagiri Masanori , Yamada Masanori 
Published: October 2007

AbstractSlow reacting substance is released from cytochalasin B treated human polymorphonuclear leukocytes by incubation with zymosan and fresh autologous serum.It is reversed by FPL 55712, a specific endorgan antagonist of SRS‐A and the process is confirmed to involve LTC4, LTD4, LTE4 by High‐Performance Liquid Chromatography.The levels of SRS from PMN by the non‐immunological stimuli are significantly higher in asthma group than in control group.SRS is inhibited with pretreatment of theophylline and histamine, and the suppressed release of SRS is recovered by adding cimetidine, H2‐brocker.Histamine appears to inhibit SRS release through H2‐receptor.The role of neutrophils in IgE mediated hypersensitivity was discussed.
Comparison of New Sustained‐Release Theophylline (E‐0686) and Theo‐Dur
Authors: Masaki Takuro , Nagakura Toshikazu , Inui Hiroyuki , Umesato Yoshihiro , Obata Toshihiko , Likura Yoji 
Published: October 2007

AbstractNew sustained‐release theophylline (E‐0686) was administered to asthmatic children to study changes in serum theophylline level and its reproducibility. Results are as follows:

t‐Max. of E‐0686 was shorter than that of Theo‐Dur, however, E‐0686 could maintain a satisfactory serum theophylline level at 12 hours on a single dose.
A steady state was reached after three days on a multiple dose of E‐0686. P‐T difference of E‐06 was 5.17 μg/ml, which could be sufficient for sustained‐release theophylline.
Changes in serum theophylline level of E‐0686 was highly reproducible.
A Survey of HBs Antigenmia among Healthy Inhabitants in Kyungpook Province, Korea
Authors: Dong Hak Shin , Jung Ju Kim , Young Choon Park , Jung Ju Yoon , Rac Kyun Ro , Jung Han Park 
Published: October 2007

AbstractThe prevalence of hepatitis B surface antigen (HBs Ag) in various regions of the world is estimated to range from 0.1% to 15%. The area with high prevalence is the west Pacific region. The carrier rate of hepatitis B surface antigen among 1,310 healthy residents in Taegu city, Korea ws investigated in November 1982. Another sample of 729 pregant women and 43 neonates born to HBs Ag‐positive mothers was tested to survey the vertical transmission of HBs Ag between mother and infant from February 1982 to May 1982.Overall prevalence of HBs Ag was 5.6% in 2,039 residents composed of 1,310 inhabitants and 729 pregnant women. The occurrence of HBs Ag was higher in males than females. The correlation between HBs Ag positivity and the socio‐economic status of samples classified into residence, family numbers per room and education level of fathers indicated little of significance but the difference of the HBs AG carrier rate in the group with a surgical history was significantly higher than the group without a surgical history. Acupuncture showed no influence on the HBs Ag carrier rate.43 of 729 pregnant womenad HBs Ag in their sera but none of their neonates were carriers of HBs Ag. Follow‐up tests in 35 infants at 3 months of age and in 32 infants at 6 months of age showed seroconversion to HBs Ag positivity in one infant in each test ‐ but it was the same infant in each case. 31 husbands of HBs Ag ‐ positive women and 20 controls whose wives were HBs Ag ‐ negative were examined. Only one in the control group was a carrier of HBs Ag. These data suggest that close person to person contact transmission of HBV via sexual contact and kissing, etc., are the most probable transmitting modes of HBV if one has susceptibility.
Congenital Heart Disease in a Case with Fetal Alcohol Syndrome: Clinical And Postmortem Findings
Authors: Sonada Tohru , Ohdo Shozo , Sennari Eiichi , Madokoro Harumichi , Kunio  
Published: October 2007

AbstractClinical and autopsy findings of a male patient with fetal alcohol syndrome, centering on congenital heart disease, are reported.Major clinical findings included developmental retardation, irritability, short palpebral fissures, thinned upper‐lip vermillion, hypoplastic philtrum, anteverted nostrils, short fifth fingers, palmar transverse creases and congenital heart disease. In addition, autopsy revealed that congenital heart disease was manifested as mitral regugitation, aortic stenosis and pulmonary stenosis
Right Pulmonary Artery Measurements in Term and Preterm Neonates during the Early Newborn Period: Hemodynamic Correlation and Clinical Significance
Authors: Ortiz Edgardo E. , Oguchi Kouki , Misawa Hitoshi , Agata Youtaro , Hiraishi Satoshi , Nishida Hiroshi , Yashiro Kimio 
Published: October 2007

AbstractRight pulmonary artery (rPa) diameter was measured during the first hour of life, then during the next 23 hours, at 72 hours and at 120 hours in 62 normal term and 14 normal preterm neonates by M‐mode echocardiography via the suprasternal notch. Left atrium (LA) and aortic (Ao) diameters were likewise determined from the standard parasternal view. Comparison was also made with rPA values of 34 patients with patent ductus arteriosus (26), persistent fetal circulation (6) and cyanotic congenital heart disease (2).In normal term babies, the mean rPA size changed significantly during the 4 periods of examination with diameters of 4.6 mm, 5.5mm, 5.2mm and 4.7 mm respectively. Among preterm babies, mean rPA diameter at 24 hours was 3.8 mm, at 72 hours, 3.8 mm, and at 120 hours, 3.3 mm. unlike those in term babies, the changes in preterm babies were not significant. LA dimensions and LA/Ao ratio were more variable. Furthermore, rPA measurements reliably differentiated clinical conditions with increased or decreased pulmonary blood flow. Thus, our data confirm the significance of rPA measurement as it closely correlates with the hemodynamic changes in the early neonatal period in normal and abnormal term and preterm babies.
Incidence and Etiology of Mental Retardation in Patients with Congenital Heart Disease
Authors: Ohdo Shozo , Madokoro Harumichi , Sonoda Tohru , Matsuoka Yuji , Sennari Eiichi , Okishima Takahiro , Suzumiya Hiroko , Nishiguchi Toshihiro , Hayakawa Kunio 
Published: October 2007

AbstractOf 1,235 patients (609 male; 626 female) with congenital heart disease for whom types, etiology and associated congenital anomalies were determinable, 129 patients (10.4%) had mental retardatin. Patients with congenital heart disease complicated by mental retardation included 70 (54.3%) with chromosome aberrations, three(2.3%) with single gene disorders, two (1.6%) caused by environmental insult, and two (1.6%) with other recognized syndromes. Among the remaining 52 patients, asphyxia at birt was noted in 16, including 12 complicated by multiple malformations, and 4 in whom mental retardedation was presumed to be due to the asphyxia. In the remaining 36 patients, the incidence of the complication of mental retardation in cyanotic congenital heart disese was significantly higher than that in acyanotic congenital heart disease was signicantly higher than that in acyanotic congenital heart disease. Patients with congenital heart disease of unknown etiology associated with mental retardation included those from two families considered to have new pedigree syndromes.
Leukemic Cell Lysis by Autologous Lymphocytes in Childhood ALL: Generation of Cytolysis by Lymphocytes Activated With Cultured Non T Non B Leukemic Cell Lines
Authors: Yamamoto Masuji 
Published: October 2007

AbstractThe lysis of leukemic cells by autologous lymphocytes was studied in the common type of acute lymphoblastic leukemia (ALL) in childhood using the 10‐hour51Cr release assay. Peripheral blood lymphocytes (PBL) from common ALL patients lysed autologous leukemic cells (% lysis: 19–45%), when co‐cultivated in vitro with cultured non T non B leukemic cell lines (NALM 16, Reh and NALL 1). The effector cells were cytotoxic T lymphocytes (CTL) possessing Leu‐1 and Leu‐2a antigens. The effector CTL were cytotoxic not only for autologous leukemic cells but for cultured non T non B leukemic cell lines, whereas they did not lyse human T cell (CCRF‐CEM), B cell (Daudi) and natural killer cell lines (SPI‐802). Cold target competition assays demonstrated that leukemic cells from childhood common ALL and several non T non B leukemic cell lines shared an antigenic determinant(s) recognized by CTL.
Childhood Leukemia and Lymphoma: Long‐Term Sequelae in Visual, Auditory and Vestibular Function
Authors: Hara Toshiro , Ishii Eiichi , Ueda Kohji , Nishida Yukiaki , Kiyosawa Reiko , Sanui Hiroki , Inomata Hajime , Miyazaki Sumio 
Published: October 2007

AbstractTwenty‐six children in continuous complete remission from leukemia or lymphoma and no longer receiving chemotherapy were studied to determine the long‐term sequelae in visual, auditory and vestibular function. Ophthalmologic examination revealed cataracts in five patients and an abnormality in the retina in one patient. These abnormalities were not associated with any disturbance of visual acuity. By otorhinolaryngologic examination, slight hearing loss was observed in five patients and an abnoormal righting reflex in one patient. The etiologies of these abnormal findings in visual, auditory and vestibular function were discussed.
Natural History of Hepatitis B Virus Carriers Born to Hepatitis B Virus Carrier Mothers
Authors: Eto Takashi , Shiraki Kazuo 
Published: October 2007

AbstractNinety‐five infants born to hepatitis B virus (HBV) carrier women were followed without hepatitis B immune globulin injections over five months. Twenty‐one infants (22%) became HBV carriers. These 21 HBV carrier children were followed and the mean follow‐up period is six years and nine months. Eighteen mothers (85.7%) of these HBV carrier children were HBeAg positive in perinatal period. One was both HBeAg and anti‐HBe negative and the status of the other two was unknown. The mean appearance time of HBsAg is 2.0 ± 1.2 months. Nine carrier children (42.9%) became HBeAg negative in the observation period. In seven cases (33.3%), seroconversion from HBeAg to anti‐HBe was observed. In six of seven seroconverted cases, liver dysfunction was observed from the HBeAg positive phase and the liver function normalized within one year after the appearance of anti‐HBe except in one case. The mean values of AST (Aspartate aminotransferase or SGOT) and ALT (Alanine aminotransferase or SGPT) of the seroconverted group during the whole observation period were significantly higher than those of the persistent HBeAg positive group. The HBeAg positive rate decreases year by year and inversely the anti‐HBe positive rate increases. At 8 years old, the former rate is 55.6%, and the latter rate is 33.3%. The mean annual disappearance rate of HBeAg under eight years is 10.1 ± 5.8% and the mean annual appearance rate of anti‐HBe under eight years is 6.1 ± 5.8%. The higher the mean annual disappearance rate of HBeAg, the lower the positive rate of HBeAg in pregnant women. This may contribute to the decrease in the appearance of new HBV carriers.
Pre‐B Cells and B Lymphocytes in Human Cord Blood and Adult Peripheral Blood
Authors: Okino Fumiko 
Published: October 2007

AbstractThe frequencies of pre‐B cells and B lymphocytes subpopulations were studied in 43 cord blood and 21 adult peripheral blood samples using a direct immunofluorescence double staining method.We found pre‐B cells in 40 out of 43 cord blood samples studied, a rate of 93%, and in 16 of 21 adult blood samples, a rate of 76%. The mean frequency of pre‐B cells in cord blood lymphocytes was 0.7%, while that in adult blood lymphocytes was 0.2%. The pre‐B cells in both groups were all small pre‐B cells.The mean frequency of B lymphocytes in cord blood was 11.4%, higher than that in adult blood (5.4%). The difference in B lymphocyte frequency between cord blood and adult blood was exclusively due to high frequency of surface IgM‐positive and IgD‐positive B lymphocytes in the cord blood.
The Study of HLA, ICA and Autoantibodies in Japanese Type 1 Diabetes Mellitus
Authors: Kida Kaichi , Mimura Goto , Kobayashi Tetsuro , Nakamura Koichi , Sonoda Shunro , Inoue Hiroo , Tsuji Kimiyoshi 
Published: October 2007

AbstractHLA, ICA (islet cell antibody) and autoantibodies were studied in 65 Japanese patients with type 1 diabetes mellitus to elucidate the existence of immuno‐genetic heterogeneity. Patients with autoantibodies had increased frequencies of HLA DRw9 antigen and of HLA haplotype of Bw61‐DRw9, and a slow decay of ICA, while patients without autoantibodies had increased frequencies of HLA DR4 antigen and of HLA haplotype of Bw54‐DR4, and a rapid decay of ICA. These findings support the concept of immunogenetic heterogeneity in Japanese type 1 diabetes mellitus.
Release of High Molecular Weight Neutrophil Chemotactic Activity from Human Cultured Basophilic Cells
Authors: Nagakura Toshikazu , Shichijo Kozaburo , Likura Yoji , Kobayashi Miyuki , Saito Hirohisa , Otani Takeshi 
Published: October 2007

AbstractWe have shown that cultured basophilic cells, derived from human cord blood cells, release histamine and high molecular weight neutrophil chemotactic activity (HMW‐NCA), in a dose‐dependent manner following calcium ionophore and anti‐IgE challenge. The HMW‐NCA detected from human cultured basophilic cells had a similar molecular weight to that of human chopped lung challenged by anti‐IgE as determined by gel filtration chromatography. These results suggest that cultured basophilic cells might be employed for research into the chemical mediators involved in immediate hypersensitivity.
Analysis of Proteins in Unconcentrated Urine
Authors: Miyata Hiroshi , Yamamoto Takashi , Murata Ryogo , Kinoshita Tomohiro , Maki Sunao 
Published: October 2007

SummaryWe investigated methods for measurement of β2‐microglobulin, lysozyme, IgG and other globulin fragments such as Fc, F(ab')2, K‐and Δ‐chains in unconcentrated urine. A log‐log correlation was observed between the percent transferrin clearances and the molecular weights of β2‐microglobulin, lysozyme, transferrin and IgG in normal children by quantitative analysis. Glomerular damage was suggested in patients who excreted urinary protein in excess of 1 g/m2/ day. The selectivity patterns showed persistence of glomerular disorders in patients with membranoproliferative glomerulonephritis, crescentric glomerulonephritis, glomerulonephritis due to Henoch‐Schonlein purpura and lupus nephritis, in spite of decrease in urinary protein excretion after treatment.Scanty globulin fragments were found in urine. The ratio of dimer‐ and monomer‐light chains found varied depending on the pathogenesis.Electrophoretic figures seen by the Western blot method were able to differentiate urinary proteins using unconcentrated urine.A combination of the procedures in this report could be useful to evaluate the severity and to monitor the progress of nephropathy.
Anticoagulant Combination Therapy of Gabexate Mesilate and Urokinase in Purpura Fulminans
Authors: Mimura Shunji , Kutsuna Tomoko , Tsukidate Kouichi , Iwase Katsuhiko 
Published: October 2007

AbstractAn attempt was made to combine anticoagulant therapy with gabexate mesilate and urokinase in a case of purpura fulminans developing after varicella infection. One week after the initiation of the treatment, the gangrenous extremities fully recovered without significant tissue necrosis. This is probably the first case of treatment of the disease that brought an immediate result.
Growth Response to Daily Subcutaneous Administration of Growth Hormone
Authors: Kikuchi Kiyoshi , Sudo Masakatsu , Miyarnoto Atsuko , Ohie Takaharu , Mori Chuzo , Mikawa Haruki 
Published: October 2007

AbstractThe effect on growth rate of daily subcutaneous (sc) administration of growth hormone (GH) was studied in seven GH‐deficient children. All patients had been receiving conventional GH treatment (intramuscularly, twice or thrice weekly) for three to six years. The growth‐promoting effect of conventional treatment gradually decreased in these seven patients [4.0 ± 0.3 (mean ± SD) cm%sol;year during the last preceding year of conventional treatment]. Following transfer to daily sc GH treatment without increase in weekly dosage, all seven patients showed an increase in growth rate (7.5 ±1.1 cm%sol;year, P>0.001). During the period of daily sc GH treatment, the pubertal stage did not advance in six of the seven patients. An increase in Δheight age%sol;Δbone age ratio was observed in six patients. None of the patients developed antibodies against GH. Local reactions were not observed at the injection site. Daily sc GH injections were tolerated without complaint. In conclusion, daily sc GH treatment is recommended for patients whose growth response to conventional GH treatment is poor.
Nasal Application of Inactivated Influenza Vaccine
Authors: Kimura Mikio , Kuno‐Sakai Harumi , Takesue Ryozo , Ozaki Kazuyo 
Published: October 2007

AbstractIntranasally‐ rpplied inactivated influenza vaccines, which have been made for subcutaneous use, induced local production of specific IgA antibodies. There is a good prospect of practical use of inactivated influenza vaccines applied intranasally.
Relation between Urinary Dopamine and Sodium Output in Term Infants
Authors: Igarashi Noboru , Okuda Norihiko , Sato Tamotsu 
Published: October 2007

AbstractThe present study was designed to investigate the relation between endogenous dopamine and natriuresis during the early postnatal days in term infants. Urinary dopamine levels were measured by high‐performance liquid chromatography in the initial urines of 61 full‐term male infants and in serial collected urines at 3‐hour intervals during the first three days in five full‐term male. infants. Dopamine excretion rate (ng/mgCr or ng/hr) correlated significantly with sodium excretion rate in both the initial urines (mEq/mgCr) and serial collected urines (mEq/hr). In the initial urines, dopamine excretion rate (ng/mgCr) did not correlate with aldosterone excretion rate (ng/mgCr), which showed an inverse relation with sodium excretion rate (mEq/mgCr), but with cyclic AMP values (nmol/mgCr). In addition, dopamine excretion rate (ng/hr) significantly correlated with cyclic AMP excretion rate (nmol/hr) in one infant.Although the significance of the direct relation between urinary dopamine and sodium output needs to be further investigated, it is possible that endo‐genously produced dopamine may play a role in natriuresis, via the cyclic AMP producing system, during the early neonatal period.
The Murphy‐Bowman Protocol in the Treatment of Childhood Non‐Hodgkin's Lymphoma
Authors: Armata Jerzy , Cyklis Romana , Dhiniewska Agnieszka 
Published: October 2007

AbstractTwenty‐two consecutive previously untreated children with stage III and IV non‐lymphoblastic non‐Hodgkin's lymphoma (NHL) and with B‐acute lymphoblastic leukemia (B‐ALL) were treated according to the Murphy‐Bowman protocol. The remission rate was 82%. The estimated long‐term survival rate was 49% and the event‐free survival 41% (in stage III 57% and 53% and in stage IV and B‐ALL 20% and 0%, respectively). The protocol is effective in stage III but fails in stage IV and B‐ALL, which corresponds to the results obtained by other investigators using this or similar protocols.(Acta Paediatr Jpn 1988; 30: 204–208)
Outcome of the Treatment of Inborn Errors of Metabolism
Authors: Watts R. W. E. 
Published: October 2007

AbstractThe use of specific dietary restrictions, cofactor administration, mobilisation of insoluble substances, environmental modifications, product replacement and selective enzyme inhibition are now established for the treatment of some inborn errors of metabolism. There is no generally accepted application for enzyme administration, cytopharmacology (manipulation of the cytoskeleton) or for cell transplantation except for bone marrow transplantation in disorders where the bone marrow is primarily at fault. The other uses of bone marrow transplantation which have been proposed require further evaluation. Results of recent research suggest that the scope of this approach is gradually being widened. There is also scope for development in the field of organ transplantation taking advantage of recent technical1 and immunological progress. The treatment of inborn errors of metabolism by genetic modification is not yet on a practical clinical level; more laboratory and animal studies are needed before this can be attempted in man. Adenosine deaminase deficiency appears to be the disease in which this will be first attempted using a retroviral vector to insert the gene into the genome of pluripotential bone marrow cells.
PKU and NON‐PKU Hyperphenylalaninemia: Differentiation, Indication for Therapy and Therapeutic Results
Authors: Trefz Friedrich K. , Lichter‐Konecki Uta , Konecki David. S. , Schlotter Magdalena , Bickel Horst 
Published: October 2007

AbstractThe differential diagnosis of phenylalanine hydroxylase deficiency (PAHD) by biochemical methods is difficult. Using standardized oral protein loading or the intravenous deuterated phenylalanine (phe) load in 46 patients with PAHD, three groups could be distinguished: 1) Phenylketonuria (PKU) with plasma phe levels over 20 mg% under the protein load and with residual activities of less than 1% of normal; 2) mild PKU with plasma phe of 10–20 mg% and residual enzyme activities of 1–3%; 3) Non‐PKU hyperphenylalaninemia with plasma phe levels of less than 10 mg% and residual enzyme activities of more than 3%. Psychomotor development in 32 untreated patients with PAHD showed that there is a high risk of brain damage for all patients with in vivo residual activities of less than 3% of normal. Restriction fragment length polymorphism (RFLP) haplotypes at the phenylalanine hydroxylase (PAH) locus in 60 German patients with PAHD showed that 90% of the mutant alleles are confined to four distinct haplotypes. Using an oligonucleotide probe for the splicing mutation associated with mutant haplotype 3 a close association between the mutation and the haplotype 3 has been observed. There is also an association between haplotypes 2 and 3 and PKU patients with residual enzyme activities of less than 1%. However, in only 37% of our patients with PAHD could a direct diagnosis of the mutations in the PAH gene be made. More knowledge of other mutations in the PAH gene is necessary to differentiate patients with PAHD on the DNA level.