bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insomnia and creativity in Chinese adolescents: mediation through need for cognition
Authors: Ren Xiaoyang , Shi Min , Si Si 
Published: March 2024

Abstract
Background
Creativity is an essential cognitive ability that plays a crucial role in advanced thinking. While previous research has demonstrated the impact of insomnia on cognitive function, its effects on creativity in Chinese adolescents remain unclear. This study explored the relationship between insomnia (specifically, daytime and nighttime disturbances) and creativity in adolescents. Additionally, it examined the potential mediating effect of the need for cognition on this relationship.

Methods
Questionnaires were administered to 302 adolescents to measure their creativity, need for cognition, and insomnia levels using the Williams Creative Tendencies Scale, Need for Cognition Scale, and Bergen Insomnia Scale, respectively. Regression analysis was conducted to examine the direct impact of insomnia on creativity. Furthermore, a mediation model was constructed to investigate the role of the need for cognition in mediating the relationship between insomnia and creativity.

Results
The findings of the present study indicated that insomnia had a direct impact on the creativity of adolescents, demonstrating a time-of-day effect. Daytime disturbances were found to have a positive correlation with overall creativity and imagination, whereas no significant direct effect was found between nighttime disturbances and creativity. Further analysis revealed that insomnia, specifically daytime disturbances, might influence creativity by affecting the individual’s need for cognition. However, no similar indirect effects were observed for the relationship between nighttime disturbances and creativity.

Conclusions
Our findings indicate that adolescents might experience improved creativity as a result of daytime disruptions, and the level of need for cognition could play a crucial role in understanding the link between insomnia and creativity in adolescents.
Hydrological constraints on the potential of enhanced geothermal systems in the ductile crust
Authors: Scott Samuel , Yapparova Alina , Weis Philipp , Houde Matthew 
Published: March 2024

AbstractContinental crust at temperatures > 400 °C and depths > 10–20 km normally deforms in a ductile manner, but can become brittle and permeable in response to changes in temperature or stress state induced by fluid injection. In this study, we quantify the theoretical power generation potential of an enhanced geothermal system (EGS) at 15–17 km depth using a numerical model considering the dynamic response of the rock to injection-induced pressurization and cooling. Our simulations suggest that an EGS circulating 80 kg s−1 of water through initially 425 ℃ hot rock can produce thermal energy at a rate of ~ 120 MWth (~ 20 MWe) for up to two decades. As the fluid temperature decreases (less than 400 ℃﻿), the corresponding thermal energy output decreases to around 40 MWth after a century of fluid circulation. However, exploiting these resources requires that temporal embrittlement of nominally ductile rock achieves bulk permeability values of ~ 10–15–10–14 m2 in a volume of rock with dimensions ~ 0.1 km3, as lower permeabilities result in unreasonably high injection pressures and higher permeabilities accelerate thermal drawdown. After cooling of the reservoir, the model assumes that the rock behaves in a brittle manner, which may lead to decreased fluid pressures due to a lowering of thresholds for failure in a critically stressed crust. However, such an evolution may also increase the risk for short-circuiting of fluid pathways, as in regular EGS systems. Although our theoretical investigation sheds light on the roles of geologic and operational parameters, realizing the potential of the ductile crust as an energy source requires cost-effective deep drilling technology as well as further research describing rock behavior at elevated temperatures and pressures.
Deformation characteristics and instability mechanism of large-scale anti-dip rock slides
Authors: Wang Xuebing , Zhang Nan , Zhang Zhihua , Wang Luqi , Yu Shu , Zhao Peng , Yan Guoqiang 
Published: March 2024

AbstractThe anti-dip bedding rock slopes have threatened global infrastructure construction and urban expansion seriously. Taking the Guang'an Village rockslide as an example, this paper firstly studied the deformation characteristics of the rockslide with anti-dip bedding structure based on in-situ investigation and monitoring, and then the relevant influencing factors were summarized. On this basis, a new evolution model of continuous-pushing-section pressing locked-section and the instability mechanism of the rock slope were proposed. Finally, the applicability of the model and the deformation tendency of the rock slope were further discussed. A catastrophic sliding event has once occurred in the Guang'an Village rockslide in 2017, after which the deformation of the potential source area III (PSA-III) was accelerating. The presence of the sliding-prone geological structure provides the basic conditions for the deformation of the rock slope and the development of the sliding zone. Rainfall is the major external trigger that promotes the deformation. As the sliding zone extends forward, the overlying deformation body will keep on pushing against the preceding rock mass, which will contribute to the forward extension of the sliding zone as well. When the final locked section is crushed, the rock slope will lose balance. According to the observation in the field, the PSA-III is in the late stage of the deformation-increasing phase currently. This study can provide a reference for the analysis of failure mechanism and the design of monitoring and mitigation of other large anti-dip bedding rock slides.
ProjectDRIVE: study protocol for a randomized controlled trial to improve driving practices of high-risk teen drivers with a traffic violation
Authors: Yang Jingzhen , Peek-Asa Corinne , Zhang Ying , Hamann Cara , Zhu Motao , Wang Yang , Kaur Archana , Recker Robyn , Rose Dominique , Roth Lisa 
Published: March 2024

Abstract
Background
Teen drivers with a traffic violation are at increased risk for crashes and crash-related injuries; however, most parent-focused interventions target teen drivers with supervised learner’s permits. Very few interventions are implemented at the probationary driver's license stage or target high-risk teen drivers, such as those with traffic violations. This paper describes the protocol of ProjectDRIVE, A Randomized Controlled Trial to Improve Driving Practices of High-Risk Teen Drivers with a Traffic Violation, which targets improving parent-teen communication about safe driving practices to reduce unsafe driving behaviors and traffic violation recidivism of teen drivers cited for traffic violation.

Methods
Teen drivers (ages 16 or 17) cited for a moving violation and the parent/legal guardian most involved with the teen’s driving are recruited from juvenile traffic courts following their required court hearing. After completing informed consent/assent, enrolled dyads are randomized into one of three groups using stratified block randomization: control, device feedback only, or device feedback plus parent communication training. Participating dyads are followed for 6 months with 3 months of active intervention. Using in-vehicle device and smartphone application technology, the study provides real-time and cumulative driving feedback to intervention teens and collects continually recorded, objectively measured driving outcome data throughout the teen’s study participation. Primary outcomes include rates of risky driving events and unsafe driving behaviors per 1000 miles driven. Secondary outcomes include traffic violation recidivism up to 12 months following study completion and frequency and quality of parent-teen communication about safe driving practices.

Discussion
Through partnership with the local juvenile traffic courts, this study integrates recruitment and randomization into existing court practices. Successfully completing this study will significantly impact juvenile traffic court’s practices and policies by informing judges’ decisions regarding the driving safety programs they refer to teens to prevent motor vehicle crashes and crash-related injuries and deaths.
Trial registration The study was registered on ClinicalTrials.gov Registry (NCT04317664) on March 19, 2020, https://clinicaltrials.gov/study/NCT04317664 and updated on April 27, 2021. This protocol was developed per the SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) Checklist.
A brief review of single silicate crystal paleointensity: rock-magnetic characteristics, mineralogical backgrounds, methods and applications
Authors: Kato Chie , Usui Yoichi , Sato Masahiko 
Published: March 2024

AbstractSingle silicate crystals hosting tiny magnetic inclusions are remarkable targets to study the paleointensities of the Earth and extraterrestrial samples. Since the pioneering work done in late 1990s, paleointensity studies using various silicate minerals such as feldspar, quartz, zircon, pyroxene, and olivine with magnetic inclusions trapped during grain growth or exsolved from the host phase have been reported. It has been shown that some single crystals have the ability to record paleomagnetic information as reliable or more reliable than the whole rock, by direct comparison of the obtained paleointensity estimate from single crystal and the whole-rock sample or the magnetic observatory data. Various rock-magnetic studies also support the fidelity of these crystals. Here, we provide a brief review of the rock-magnetic characteristics of the single crystals, the mineralogical background of the hosting silicates, and experimental procedures developed to obtain reliable data from magnetically weak samples with distinctive rock-magnetic features. We also overview the studies on paleointensity and related topics on various terrestrial and extraterrestrial samples published mainly after the comprehensive reviews in late 2000s. The present review covers the advantages as well as the limitations and caveats of paleointensity studies using single crystal samples and will help readers who wish to utilize this technique in their research.
Graphical Abstract
Early Jurassic extrinsic solar system dynamics versus intrinsic Earth processes: Toarcian sedimentation and benthic life in deep-sea contourite drift facies, Cardigan Bay Basin, UK
Authors: Pieńkowski Grzegorz , Uchman Alfred , Ninard Krzysztof , Page Kevin N. , Hesselbo Stephen P. 
Published: March 2024

AbstractThe Cardigan Bay Basin (UK) may have functioned as a deep and narrow strait, and thereby influenced Early Jurassic oceanic circulation through the northern and southern Laurasian Seaway, and between Boreal and Peri-Tethys domains. Toarcian hemipelagic deposits of the basin in the Mochras borehole show strongly bioturbated contourite facies. Trace fossils are strongly dominated by Phycosiphon incertum (represented by four morphotypes), which was produced by opportunistic colonizers. Thalassinoides, Schaubcylindrichnus and Trichichnus are common (the latter is a deep-tier trace fossil produced by filamentous sulfide-oxidizing bacteria with a high tolerance for dysoxia), accompanied by less common Zoophycos, Planolites, Palaeophycus, Teichichnus, Rhizocorallium, Chondrites, and dwelling and resting structures, such as cf. Polykladichnus, Siphonichnus, Skolithos, Arenicolites, Monocraterion and Lockeia. Ichnological and lithological signals suggest repetitive fluctuations in benthic conditions attributed to a hierarchy of orbital cycles (precession and obliquity [4th order], short eccentricity [3rd order], long eccentricity [2nd order] and Earth–Mars secular resonance [1st order]). The Pliensbachian–Toarcian transition appears to be a significant palaeoceanographic turning point in the Cardigan Bay Basin, starting a CaCO3 decline, and with the most severe oxygen crisis of the Tenuicostatum Zone (here dysoxic but not anoxic) ending at the onset, in the early Serpentinum Zone (Exaratum Subzone), of the Toarcian negative carbon isotope excursion (To-CIE—linked with the Toarcian Oceanic Anoxic Event occurring in the lower part in the Serpentinum Zone). This trend contrasts with the prevalence of anoxia synchronous with the To-CIE in many other settings. Minor dysoxia returned to the Mochras setting in the latest Thouarsense to Dispansum zone interval. Extreme climate warming during the To-CIE may have enhanced and caused a reversal in the direction of deep marine circulation, improving oxygenation of the sea floor. Spectral analysis of binary data on ichnotaxa appearances gives high confidence in orbital signals and allows refined estimation of ammonite zones and the duration of the Toarcian (minimum ~ 9.4 Myr).
Immune cells: potential carriers or agents for drug delivery to the central nervous system
Authors: Zhang Shan-Shan , Li Ruo-Qi , Chen Zhong , Wang Xiao-Ying , Dumont Aaron S. , Fan Xiang 
Published: March 2024

AbstractDrug delivery systems (DDS) have recently emerged as a promising approach for the unique advantages of drug protection and targeted delivery. However, the access of nanoparticles/drugs to the central nervous system (CNS) remains a challenge mainly due to the obstruction from brain barriers. Immune cells infiltrating the CNS in the pathological state have inspired the development of strategies for CNS foundation drug delivery. Herein, we outline the three major brain barriers in the CNS and the mechanisms by which immune cells migrate across the blood–brain barrier. We subsequently review biomimetic strategies utilizing immune cell-based nanoparticles for the delivery of nanoparticles/drugs to the CNS, as well as recent progress in rationally engineering immune cell-based DDS for CNS diseases. Finally, we discuss the challenges and opportunities of immune cell-based DDS in CNS diseases to promote their clinical development.
Mesenteric root pseudocyst: finding in an asymptomatic patient—a case report
Authors: Suldrup F. , Uad P. , Vaccaro A. , Mazza M. , Santino J. , Mazza O. 
Published: March 2024

Abstract
Background
Mesenteric cysts are one of the rarest abdominal tumor masses, representing a little-studied pathology. In turn, the variability and non-specificity of clinical manifestations make diagnosis difficult, as it can be reached by imaging findings due to another cause or by non-specific abdominal pain.

Case presentation
This article describes the case report of an asymptomatic 28-year-old patient who presented a 6-cm abdominal cystic mass with mixed density, which was found incidentally by computed tomography. Exploratory laparoscopy was performed followed by conversion to conventional surgery to extract the tumor mass. The anatomical pathology diagnosis was pseudocyst of the mesentery root. Mesenteric cysts are one of the rarest abdominal tumor masses, representing a little-studied pathology. In turn, the variability and non-specificity of clinical manifestations make diagnosis difficult, as it can be reached by imaging findings due to another cause or by non-specific abdominal pain.

Conclusions
Mesenteric cysts are rare, and their nonspecific symptoms often lead to diagnosis based on imaging findings. Complete laparoscopic enucleation is the standard treatment.
In vivo evaluation of tumor uptake and bio-distribution of 99mTc-labeled 1-thio-β-D-glucose and 5-thio-D-glucose in mice model
Authors: Muehlberg Fabian , Mohnike Konrad , Grosser Oliver S. , Pech Maciej , Goldschmidt Juergen , Smalla Karl-Heinz , Seidensticker Ricarda , Ümütlü Muzaffer Reha , Deniz Sinan , Ricke Jens , Steffen Ingo G. , Öcal Osman , Seidensticker Max 
Published: March 2024

Abstract
Background
To investigate the capacity of 99mTc-labeled 1-thio-β-D-glucose (1-TG) and 5-thio-D-glucose (5-TG) to act as a marker for glucose consumption in tumor cells in vivo as well as to evaluate the biodistribution of 1-TG and 5-TG. We investigated the biodistribution, including tumor uptake, of 1-TG and 5-TG at various time points after injection (0.5, 2 and 4 h) in human colorectal carcinoma (HCT-116) and human lung adenocarcinoma (A549) xenograft bearing nude mice (N = 4 per tracer and time point).

Results
Ex vivo biodistribution studies revealed a moderate uptake with a maximum tumor-to-muscle ratio of 4.22 ± 2.7 and 2.2 ± 1.3 (HCT-116) and of 3.2 ± 1.1 and 4.1 ± 1.3 (A549) for 1-TG and 5-TG, respectively, with a peak at 4 h for 1-TG and 5-TG. Biodistribution revealed a significantly higher uptake compared to blood in kidneys (12.18 ± 8.77 and 12.69 ± 8.93%ID/g at 30 min) and liver (2.6 ± 2.8%ID/g) for 1-TG and in the lung (7.24 ± 4.1%ID/g), liver (6.38 ± 2.94%ID/g), and kidneys (4.71 ± 1.97 and 4.81 ± 1.91%ID/g) for 5-TG.

Conclusions
1-TG and 5-TG showed an insufficient tumor uptake with a moderate tumor-to-muscle ratio, not reaching the levels of commonly used tracer, for diagnostic use in human colorectal carcinoma and human lung adenocarcinoma xenograft model.
Predictors of serious infections in rheumatoid arthritis—a prospective Brazilian cohort
Authors: de Almeida Ana Luisa Bagno , Guimarães Maria Fernanda B. Resende , da Costa Pinto Maria Raquel , Pereira Leticia Rocha , Reis Ana Paula Monteiro Gomides , Bonfiglioli Karina Rossi , Louzada-Junior Paulo , Giorgi Rina Dalva Neubarth , de Castro Gláucio Ricardo Werner , Radominski Sebastião Cezar , Brenol Claiton Viegas , Pugliesi Alisson , da Mota Licia Maria Henrique , da Rocha Castelar-Pinheiro Geraldo 
Published: March 2024

Abstract
Background
Infections increase mortality and morbidity and often limit immunosuppressive treatment in rheumatoid arthritis patients.

Objective
To analyze the occurrence of serious infections and the associated factors in a cohort of rheumatoid arthritis patients under real-life conditions.

Methods
We analyzed data from the REAL, a prospective observational study, that evaluated Brazilian RA patients, with clinical and laboratory data collected over a year. Univariate and multivariate analyses were performed from the adjustment of the logistic regression model Generalized Estimating Equations (GEE), with the primary outcome being the occurrence of serious infection, defined as need for hospitalization or use of intravenous antibiotics for its treatment.

Results
841 patients were included with an average follow-up time of 11.2 months (SD 2.4). Eighty-nine serious infections occurred, corresponding to 13 infections per 100 patient-years. Pulmonary fibrosis, chronic kidney disease (CKD) and central nervous system disease increased the chances of serious infection by 3.2 times (95% CI: 1.5–6.9), 3.6 times (95% CI: 1.2–10.4) and 2.4 times (95% CI: 1.2–5.0), respectively. The use of corticosteroids in moderate doses increased the chances by 5.4 times (95% CI: 2.3–12.4), and for each increase of 1 unit in the health assessment questionnaire (HAQ), the chance increased 60% (95% CI: 20–120%).

Conclusion
The use of corticosteroids at moderate doses increased the risk of serious infection in RA patients. Reduced functionality assessed by the HAQ and comorbidities were other important factors associated with serious infection in this cohort.
Effects of intra-articular injection of platelet-rich plasma on the inflammatory process and histopathological characteristics of cartilage and synovium in animals with osteoarthritis: a systematic review with meta-analysis
Authors: Garcia-Motta Homero , Carvalho Cristiano , Guilherme Evelyn Maria , de Oliveira Marcos Paulo Braz , Rossi Karina Nogueira Zambone Pinto 
Published: March 2024

Abstract
Background
Osteoarthritis (OA) affects the entire joint, causing structural changes in articular cartilage, subchondral bone, ligaments, capsule, synovial membrane, and periarticular muscles that afflicts millions of people globally, leading to persistent pain and diminished quality of life. The intra-articular use of platelet-rich plasma (PRP) is gaining recognition as a secure therapeutic approach due to its potential regenerative capabilities. However, there is controversial clinical data regarding efficacy of PRP for OA treatment. In this context, gathering scientific evidence on the effects of PRP in treating OA in animal models could provide valuable insights into understanding its impact on aspects like cartilage health, synovial tissue integrity, and the inflammatory process in affected joints. Thus, the objective of this study was to assess the effects of PRP injections on inflammation and histopathological aspects of cartilage and synovium in animal models of OA through a comprehensive systematic review with meta-analysis.

Methods
A electronic search was conducted on Medline, Embase, Web of Science, The Cochrane Library, LILACS, and SciELO databases for relevant articles published until June 2022. A random-effects meta-analysis was employed to synthesize evidence on the histological characteristics of cartilage and synovium, as well as the inflammatory process. The GRADE approach was utilized to categorize the quality of evidence, and methodological quality was assessed using SYRCLE’s RoB tool.

Results
Twenty-one studies were included in the review, with twelve of them incorporated into the meta-analysis. PRP treatment demonstrated superior outcomes compared to the control group in terms of cartilage histology (very low quality; p = 0.0002), synovium histology (very low quality; p < 0.0001), and reductions in proinflammatory markers, including IL-1 (low quality; p = 0.002), IL-6 (very low quality; p < 0.00001), and TNF-α (very low; p < 0.00001). However, PRP treatment did not yield a significant impact on PDGF-A levels (very low quality; p = 0.81).

Conclusion
PRP appears capable of reducing proinflammatory markers (IL-1, IL-6, TNF-α) and mitigating cartilage and synovium damage in animals with OA. However, the levels of evidence of these findings are low to very low. Therefore, more rigorous studies with larger samples are needed to improve the quality of evidence.

PROSPERO registration
CRD42022250314
Inflammatory myofibroblastic tumor in pediatric patients: challenges in diagnosis, multidisciplinary management, and surgical strategies
Authors: García Izchel Valdez , Gutierrez Alejandro Solano , Guzmán Sofia Brenes , Viveros Brenda Aguilar 
Published: March 2024

Abstract
Background
Inflammatory myofibroblastic tumor is a rare yet profoundly impactful condition, particularly within the pediatric population. This case report illuminates the intricate challenges of diagnosing and managing inflammatory myofibroblastic tumors in children, underscoring the importance of interdisciplinary collaboration in formulating effective treatment strategies. Notably, the choice of surgical approach holds a paramount influence on the risk of recurrence and metastasis, with wide resection with bronchotomy, lobectomy, and pneumonectomy demonstrating significantly diminished recurrence rates compared to wedge resection in bronchoscopic removal.

Case presentation
We present the case of a 3-year-old girl with a progressive, nonproductive cough, occasionally accompanied by episodes of hemoptysis and pneumonia for a year, secondary to an inflammatory myofibroblastic tumor that was removed by bronchotomy with excellent results.

Conclusion
Given the extraordinary rarity of this disease in pediatric patients, ongoing research endeavors and the accumulation of collective expertise are paramount.