bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hak Dan Kewajiban Alimentasi & Hadlhanah Anak Luar Kawin Pasca Putusan Mahkamah Konstitusi No.46/PUU-VIII/2010
Authors: Nadila Manda Sari  
Published: March 2024

AbstractIn Islam, it teaches the existence of hadlhanah, which is the term given to the rights and obligations to care for a child she is carrying, which is borne by the mother. However, in the development of law in Indonesia, the Constitutional Court Decision Number 46/PUU-VIII/2010 was born which gave real legal status to illegitimate children with their fathers. In research that uses a contextual approach and a case approach through analysis of the judge's considerations in the Constitutional Court Decision Number 46/PUU-VIII/2010, it is explained that the decision confirms that there is a legal relationship between an illegitimate child and his biological father. The inherent relationship between the two of them takes the form of a civil legal relationship and obligations attached to the father towards the illegitimate child.
Keywords: Alimentation, Hadlanah, Illegitimate Children.

Abstrak
Dalam Islam mengajarkan adanya hadlhanah yang mana sebutan ini diberikan kepada hak serta kewajiban untuk memelihara seorang anak yang dikandungnya yang mana hal ini dibebankan kepada ibu. Akan tetapi, dalam perkembangan hukum di Indonesia lahirlah Putusan Mahkamah Konstitusi Nomor 46/PUU-VIII/2010 yang memberikan kedudukan hukum nyata bagi anak luar kawin dengan ayahnya. Dalam penelitian yang menggunakan pendekatan kontekstual serta pendekatan kasus melalui analisa pertimbangan hakim dalam Putusan Mahkamah Konstitusi Nomor 46/PUU-VIII/2010 ini, dijelaskan bahwa dalam keputusan tersebut menegaskan bahwa adanya hubungan hukum seorang anak luar kawin dengan ayah biologisnya. Hubungan yang melekat diantara keduanya ini berbentuk hubungan hukum keperdataan dan kewajiban yang melekat di ayah kepada anak di luar kawin tersebut.
Kata Kunci: Alimentasi, Hadlanah, Anak Luar Kawin.
Changes and Functions of CX3CL1 in Viral Infection and Associated Diseases
Authors: Zhang Chunmei , Zhang Yusi , Zhuang Ran , Yang Kun , Chen Lihua , Jin Boquan , Ma Ying , Zhang Yun , Tang Kang 
Published: March 2024

CX3CL1, also named fractalkine or neurotactin, the only known member of the CX3C chemokine family that can chemoattract several immune cells. CX3CL1 exists in both membrane-anchored and soluble forms, each mediating distinct biological activities. CX3CL1 signals are transmitted through its unique receptor, CX3CR1, primarily expressed in microglia of central nervous system (CNS). In the CNS, CX3CL1 acts as a regulator of microglia activation in response to brain disorders or inflammation. Recently, there has been a growing interest in the roles of CX3CL1 in regulating cell adhesion, chemotaxis, and host immune response in viral infection. Here, we provide a comprehensive review of the changes and function of CX3CL1 in various viral infections such as human immunodeficiency virus (HIV), SARS-CoV-2, influenza virus and cytomegalovirus (CMV) infection, to highlight the emerging roles of CX3CL1 in viral infection and the associated diseases.
Pathology revolution? No more formalin DNA abuse!
Authors: Hoogland Agnes Marije , Niemantsverdriet Maarten , Knol Ageeth , Starre-Gaal Jose van der 
Published: March 2024

Abstract

Disease diagnosis, prognosis, and therapy choice progressively rely on good-quality DNA for molecular analysis. As tissue processing is routinely performed worldwide with ancient techniques using toxic and DNA-damaging formaldehyde, the quality of DNA isolated from embedded tissues used for diagnostics is poor. We used a novel formalin-free method to process tissues and show that, after 5 years, DNA quality is superior to formalin fixation.
Predicting transcriptional responses to novel chemical perturbations using deep generative model
Authors: Zhao Yi , Qi Xiaoning , Zhao Lianhe , Tian Chenyu , Li Yueyue , Chen Runsheng , Yang Shengyong 
Published: March 2024

Abstract

Understanding transcriptional responses to chemical perturbations is central for drug discovery, but exhaustive experimental high-throughput screening of disease and compound combinations is unfeasible. To overcome this limitation, here we present a perturbation-conditioned deep generative model named PRnet for predicting transcriptional responses to novel chemical perturbations that were never experimentally perturbed at bulk and single-cell levels. Evaluation indicated that PRnet outperformed alternative methods in predicting responses across novel compounds, pathways, and cell lines. PRnet enables gene-level response interpretation and novel compounds screening for diseases based on gene signatures. PRnet further identified and experimentally tested novel compounds candidates against small cell lung cancer and colorectal cancer. Lastly, PRnet generated a large-scale integration atlas of perturbation profiles, covering 88 cell lines and 52 tissues perturbed by various screening compound libraries. PRnet provided a robust and scalable candidate recommendation workflow and has successfully recommended drug candidates for 233 different diseases based on the atlas. Overall, PRnet is an effective and valuable tool for cell- and gene-based therapeutics screening.
Development and validation of a novel bone metastasis-associated prognostic model for breast cancer
Authors: Huang Shilei , Cao Xiaobin , Liu Jingjing , Ji Xiang , Han Yu , Wu Xuejian 
Published: March 2024

Abstract

Background
Bone is the main location where breast cancer spreads, which can greatly impact the outlook and well-being of those affected by the disease. Novel targets are crucial in clinical practice as traditional treatment for breast cancer patients with bone metastases is mostly futile. Current therapy for bone metastases in breast cancer patients is hindered by a lack of understanding of the root causes.
Methods
We created a prognostic bone metastasis signature called PABMS. The Prognostic Analysis of Bone metastases Score (PABMS) utilised genes associated with bone metastases to forecast the overall prognosis of breast cancer patients. The clinical significance and immunological environments of the signature were exhaustively examined.
Results
Differentially expressed genes (DEGs) associated with bone metastasis were identified by utilising data from the GSE14666 database in order to distinguish disseminated tumour cells (DTCs) from metastatic tumour cells (MTCs). The bone metastasis-related signature (PABMS), comprised of four genes (ZER, SBK1, L1CAM, and CXCL1), was identified. This signature exhibited a robust correlation with the overall survival of patients diagnosed with breast cancer. This was ascertained through the analysis of transcriptome data from a specific cohort of patients. The efficacy of the four-gene signature in distinguishing bone metastases was validated through the examination of protein levels in an independent cohort. There was a significant correlation between a high-risk score and an extremely adverse patient outcome, according to the findings. Stratification analysis and multivariate Cox regression demonstrated that the PABMS functioned independently as a prognostic factor. Risk score was found to positively correlate with the antigen-presenting process, inflammatory response, and expression levels of many immunosuppressive checkpoint molecules (PD-1, B7-H4, galectin-9, and FGL-1). The findings suggested that patients at high risk exhibited inhibition of the immune response.
Conclusion
This work created a practical signature using differentially expressed genes associated with bone metastases. This attribute has the potential to function as a highly effective predictive instrument and contribute to the enhancement of the cancer therapy methodology.
Improvement of Physicochemical Properties of Refined Peanut Oil with Dried Olive Leaf: Gray Scale Optimization
Authors: GAMLI Omer Faruk , kaya Yoncagul yavas 
Published: March 2024

Abstract

Peanut is a well-known lipid and protein source for nutrition and its oil is considered to be nutritious and healthy, owing to its fatty acid composition and the presence of natural bioactive components. Olive leafs are the major by-products of oil processing and its industry. The phenolic content of peanut oil was 78.15 and varied between 271.8 and 431.6 mg GAE/kg depending on the increasing amount of olive leafs respectively (2.5-7.5%). The scavenging activity of peanut oil was as 3.8% and varied between 40.17,82.5 and 91.01% respectively. The effects of olive leaf amount and storage time on the extinction coefficients of peanut oils (K225,K232 and K270) were statistically insignificant whereas PV (meO2/kg), total and free acidities (%) of peanut oils were affected significantly. Chlorophyll a and b values of refined peanut oils varied between 0.69 and 1.238 (mg/L);0.14 and 1.195 8-(mg/L) respectively. Olive leafs caused statistically decreased L* values but increased a* and b* values.
InGaN-based Blue Resonant Cavity Micro-LED Combined with Red-Green-Yellow Quantum Dot Color Conversion Layer for Wide Color Gamut and Energy- Efficient Full-Color Displays
Authors: Lee Tzu-Yi , Huang Chien-Chi , Hung Yu-Ying , Chen Fang-Chung , Hong Yu-Heng , Kuo Hao-Chung 
Published: March 2024

Abstract

The technology of RGBY micro resonant cavity light emitting diodes (micro RCLEDs) based on quantum dots (QDs) is considered one of the most promising approaches for full-color displays. In this work, we propose a novel structure combining a high color conversion efficiency (CCE) QD photoresist (QDPR) color conversion layer (CCL) with blue light micro RCLEDs, incorporating an ultra-thin yellow color filter. The additional TiO2 particles inside the QDPR CCL can scatter light and disperse QDs, thus reducing the self-aggregation phenomenon and enhancing the eventual illumination uniformity. Considering the blue light leakage, the influences of adding different color filters are investigated by LightTools(8.6) illumination design software. Finally, the introduction of low-temperature atomic layer deposition (ALD) passivation protection technology at the top of the CCL can enhance the device reliability. The introduction of RGBY four-color subpixels provides a viable path for developing low-energy consumption, high uniformity, and efficient color conversion displays.
Techno-economic evaluation of soap production from waste cooking oil with additives derived from citrus peel waste.
Authors: Mwamba Beatrice Walelu , Brobbey Mensah Sarpong , Leodolff Bianke , Peters Shaun , Teke George Mbella , Mapholi Zwonaka 
Published: March 2024

Abstract

In the pursuit of sustainable waste management practices, this study explores the technical and economic feasibility of soap production using waste cooking oil (WCO) combined with citrus peel waste (CPW), with a specific focus on extracting limonene as soap additives. The preliminary experimental investigations indicated that soaps produced from WCO have similar qualities if properly treated, compared to those produced from virgin oils. Also, including limonene effectively addresses WCO odours and demonstrates a promise of anti-microbial properties against E.coli. From the comprehensive techno-economic evaluation of WCO-based soap production, a focus on industrial symbiosis by integrating CPW-derived limonene is necessary. Results show that soap production with WCO and on-site additive in limonene (scenario 3) was competitive, with an IRR of 19% compared to 16% when the soap was produced using WCO and the additives were purchased (scenario 4). Also, the minimum selling prices of soaps were comparable for scenarios 3 (R 160.53/kg) and 4 (R 159.87/kg), further building on the economic viability of on-site limonene production. Hence, the environmental potential and economic viability of integrating WCO and CPW into soap production seem to be a profitable approach should on-site production be implemented.
Optimization of traction parameters for lumbar scoliosis
Authors: He Wei , Li Jialong , Wang Jiayu , He Da , Song Kai 
Published: March 2024

Abstract

Background Scoliosis is a high incidence disease that endangers the physical and mental health of adolescents. Traction therapy, as a conservative treatment plan, is helpful to improve the recovery speed of patients by studying the influence of different traction factors on the therapeutic effect.
Methods Based on the thin layer CT data of the lumbar spine of a 16-year-old patient with scoliosis, Mimics21.0 was used to extract the 3D digital model, and Geomagic Wrap2021 was used to perform the smooth surface. After that, SolidWorks was used to manually construct the structures, such as the intervertebral disc, and Ansys17.0 was used to add constraints, ligaments, and other features. Three-factor ANOVA was carried out after an orthogonal experiment that considered traction mode, traction angle, and traction force was finished.
Results ① A three-dimensional biomechanical model of lumbar scoliosis was created.② The model's correctness was confirmed by comparing it to the corpse and other finite element models, as well as by verifying it under a range of working settings.③Traction force (P=0.000), traction angle (P=0.000), the interaction between traction force and traction angle (P=0.000), and the interaction between traction mode and traction angle (P=0.045) were all significant.④The interaction between traction force and traction angle has the most significant effect on Cobb, and traction with a certain angle is better than traditional axial traction.⑤ Traction mode is not significant, but the interaction between traction mode and traction angle is significant.
Conclusions A certain angle of traction can aid in improving outcomes and the traction force can be suitably decreased in the clinical formulation of the traction plan. The uniformity of correcting effect is more favorable when higher fixation techniques like positive suspension or traction bed traction are used, as opposed to overhanging traction.
Analysis of integrating PIK3CA and NF1 mutations into Glioblastoma multiforme prognostication and immunotherapy treatment strategy
Authors: Chen Qinbiao , Lu Huijiao , Zhong Cheng 
Published: March 2024

Abstract
Objective
The potential mechanisms of PIK3CA and NF1 expressions in GBM have been poorly elucidated. Risk-score analysis combined with clinicopathological characteristics to assess the prognostic value and immunotherapy efficacy of 6-genes signature.
Methods
We performed the whole exosome sequencing profiling on samples form patients with GBM. The association of PIK3CA and NF1 expression within the GBM have received cross-validations by MR methods and the risk-score analysis of 6-gene signature. The construction of 6 genes prognostic signature based on The Cancer Genome Atlas (TCGA) GBM cohort, the Gene Expression Omnibus (GEO), and IMvigor210 cohort.
Results
MR study demonstrated that PIK3CA and NF1 expressions were closely related with the risk of GBM patients by the IVW method. And then the construction of 6-gene signature was classified into high-risk and low-risk groups through the median risk-score of regression formula to predict prognosis of GBM patients. Kaplan-Meier survival showed the overall survival of distinct high- and low-risk groups. Receiver operating characteristic (ROC) curve analysis indicated the value of predictive performance of two different risk groups. In line with our WES reporters, our findings showed that the mutation of PIK3CA and NF1 was significantly associated with prognostic signature of GBM. Importantly, the individual altered gene took effect on response or resistance to ICB, such as PIK3CA. Consistent with our analysis about study individual mutations and their role in cancer immunotherapy, which might provide a novel insight on the mechanism of PIK3CA and NF1 mutation in the GBM.
Conclusions
Taken together, our MR analysis indicated the correlation between PIK3CA and NF1 expression and GBM disease, which provided a key basis for the precise prevention of the genetic mutation in the occurrence and development of GBM. The established PIK3CA and NF1 alteration-related prognostic signature was involved well in prognosis prediction as well as closely linked with immunotherapy responses. which also provided a novel and great potential in future clinical applications.
Harnessing Ligno Cellulose and Cellulose Derivative Residues for Sustainable Biomethanation With Effect of Different Transformation in Rsm Optimization
Authors: Kanakasabai p , Mahri Ahmed Said Salim Qahoor Al , Sivamani S , Qahoor Noor Mohammed Said , Banerjee Saikat 
Published: March 2024

Abstract
Biogas technology stands out as a viable energy alternative in rural areas, acclaimed for being an exemplary appropriate technology that addresses the fundamental need for fuel. By utilizing discarded and lingo cellulose derivatives such as potato peel waste sourced from vegetable markets, this technology harnesses energy in the form of biogas enriched with a high methane content. The anaerobic bacteria play a pivotal role in converting and peel wastes into biogas through a synergistic process. Crucial considerations for the biomethanation process encompass process parameters like substrate concentration, substrate and cell mass concentration. Simultaneously, kinetic parameters such as maximum specific growth rate, kinetic constant, and ultimate methane yield take precedence in the anaerobic digestion process for efficient biogas production. This study endeavors to explore the anaerobic reactions of potato and potato peel wastes within a semi-batch digester. Variations in substrate concentrations and different substrates significantly impact biogas production, leading to the development of a mathematical interpretation of the biomethanation process. Between 33.16 and 38.68 MJ/Nm3 of biogas is the energy yield obtained from this procedure. Through a meticulous mathematical analysis of experimental data, model equations correlating ultimate methane yield with diverse substrate concentrations and loading have been formulated.
Convexity non-aneurysmal subarachnoid hemorrhage caused by cerebral sinus thrombosis: a case report and literature review
Authors: Abasi Ali , Moradkhani Asra , Rahimi Shiva , Magrouni Hannah 
Published: March 2024

Abstract

Background: Convexity subarachnoid hemorrhage (cSAH) is an uncommon presentation of subarachnoid bleeding, referring to bleeding more localized to the convexities of the brain. The diagnosis of cerebral venous sinus thrombosis (CVST) can be difficult especially when patients initially present with cSAH. The authors present a case and then discuss the pathophysiology and management.
Case presentation: A 56-year-old woman with a previous history of hypertension and ischemic heart disease presented to the emergency department after experiencing it. two seizures following a severe headache. The patient’s history was negative for recent illnesses, head trauma, history of migraines, smoking, alcohol consumption, or intravenous drug use. The patient was diagnosed with CVST based on magnetic resonance venography (MRV). Genetic studies further identified homozygous mutations in the Prothrombin and MTHFR genes. Anticoagulant therapy was initiated with 60 mg of Enoxaparin twice daily and subsequently transitioned to Warfarin after 48 hours continued for 3 months, and then replaced by rivaroxaban.
Conclusions: CVST should be considered in the differential diagnosis of patients presenting with cSAH. Considering this point emphasizes the necessity of concurrent diagnosis and management.
A Price Too High: Injury and Assault Among Delivery Gig Workers in New York City
Authors: Laskaris Zoey , Hussein Mustafa , Stimpson Jim P , Vignola Emilia F , Shahn Zach , Cohen Nevin , Baron Sherry 
Published: March 2024

Abstract

The occupational health burden and mechanisms that link gig work to health are understudied. We described injury and assault prevalence among food delivery gig workers in New York City (NYC) and assessed the effect of job dependence on injury and assault through work-related mechanisms and across transportation modes (electric-bike and moped versus car). Data was collected through a 2022 survey commissioned by the NYC Department of Consumer and Worker Protection among delivery gig workers between October and December 2021 in NYC. We used modified Poisson regression models to estimate the adjusted prevalence rate ratio associations between job dependence and injury and assault. Of 1,650 respondents, 66.9% reported that food delivery gig work was their main or only job (i.e., fully dependent). About 21.9% and 20.8% of respondents reported being injured and assaulted, respectively. Injury and assault were more than twice as prevalent among two-wheeled drivers in comparison to car users. Fully dependent respondents had a 1.61 (95% confidence interval (CI): 1.20, 2.16) and a 1.36 (95%CI: 1.03, 1.80) times greater prevalence of injury and assault, respectively, than partially dependent respondents after adjusting for age, sex, race and ethnicity, language, employment length, transportation mode, and weekly work hours. These findings suggest that fully dependent food delivery gig workers, especially two-wheeled riders, are highly vulnerable to the negative consequences of working conditions under algorithmic management by the platforms. Improvements to food delivery gig worker health and safety are urgently needed and company narratives surrounding worker autonomy and flexibility need to be revisited.
Assessment of Functional Outcomes and Quality of Life after Thoracic and Lumbar Spinal Metastasis Surgery
Authors: Abousayed Mahmoud , Taha Hossam Salah , Elsayed Raafat , Salem Mostafa Salahdin , Ebeid Walid 
Published: March 2024

Abstract
BACKGROUND
Spinal metastases are being diagnosed more frequently because of increasing life expectancies and advances in the diagnosis and treatment of primary tumors.
OBJECTIVE
The aim of this study was to assess functional outcome and quality of life after surgical management for patients with spinal metastases.
METHODS
A total of thirty-three patients with thoracic and lumbar spine metastases underwent surgical management at Kasr Al Ainy Hospital, Cairo University, between November 2021 and August 2023, with one year of follow-up or until death in a prospective cohort study. For the functional outcome, the Eastern Cooperative Oncology Group Performance Status (ECOG-PS) was analyzed.
RESULTS
The mean age was 52.12 ± 13.4 years (range 23–70 years), 22 (66.7%) were females, and 11 were males (33.3%). Patients were divided into 3 groups according to the revised Katagiri score: 12 patients (36.4%) were at low risk (0 to 3), 18 patients (54.5%) were at intermediate risk (4 to 6), and 3 patients (9.1%) were at high risk (7 to 10). The mean survival was 5.44 ± 3.46 months (range 1–13), and there was no perioperative death (within one month postoperative). Sixteen patients (48.5%) survived for more than one year, and 17 patients (51.5%) died from different causes related to the natural history of tumor metastasis.
CONCLUSION
We concluded that with proper patient selection and appropriate planning and care for patients with spinal metastases, surgical intervention can improve quality of life and function. However, the clinical course of patients who survive there after surgery remains unclear. Therefore, additional long-term studies are needed.