bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Helicobacter pylori infection and laryngohypopharyngeal carcinoma: A case–control study and review of the literature
Authors: Rezaii Jalal , Tavakoli Hassan , Esfandiari Khalil , Ashegh Hossein , Hasibi Mehrdad , Ghanei Gholamreza , Khosh‐Batn Mahnaz , Rashidi Armin 
Published: September 2008

AbstractBackground.Gastroesophageal reflux, by exposing the pharynx to Helicobacter pylori (H. pylori), is a potential risk factor for laryngohypopharyngeal carcinoma. Its possible association has been inconsistent. In this case–control study, we investigated the relationship between H. pylori seropositivity and laryngohypopharyngeal carcinoma in Iran.Methods.We had 105 healthy controls (group A), 70 cases of laryngeal carcinoma (group B), and 28 cases of hypopharyngeal carcinoma group (group C). Age, sex, smoking habit, alcohol use, and H. pylori serology were determined for all subjects.Results.Groups were matched in age and alcohol use. Smoking and H. pylori seropositivity were more common in groups B and C, and male sex was more common in group B (compared with group A). In multivariate regression, the effect of smoking (p <.01, odds ratio [OR] = 2.92) and H. pylori seropositivity (p <.01, OR = 11.49) remained highly significant.Conclusion.H. pylori is an independent risk factor for laryngohypopharyngeal carcinoma. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Acute kidney injury in cirrhosis
Authors: Garcia-Tsao Guadalupe , Parikh Chirag R. , Viola Antonella 
Published: September 2008

Abstract

Acute renal failure (ARF), recently renamed acute kidney injury (AKI), is a relatively frequent problem, occurring in approximately 20% of hospitalized patients with cirrhosis. Although serum creatinine may underestimate the degree of renal dysfunction in cirrhosis, measures to diagnose and treat AKI should be made in patients in whom serum creatinine rises abruptly by 0.3 mg/dL or more (≥26.4 μmol/L) or increases by 150% or more (1.5-fold) from baseline. The most common causes of ARF (the term is used interchangeably with AKI) in cirrhosis are prerenal azotemia (volume-responsive prerenal AKI), acute tubular necrosis, and hepatorenal syndrome (HRS), a functional type of prerenal AKI exclusive of cirrhosis that does not respond to volume repletion. Because of the progressive vasodilatory state of cirrhosis that leads to relative hypovolemia and decreased renal blood flow, patients with decompensated cirrhosis are very susceptible to developing AKI with events associated with a decrease in effective arterial blood volume. HRS can occur spontaneously but is more frequently precipitated by events that worsen vasodilatation, such as spontaneous bacterial peritonitis.

Conclusion:

Specific therapies of AKI depend on the most likely cause and mechanism. Vasoconstrictors are useful bridging therapies in HRS. Ultimately, liver transplantation is indicated in otherwise reasonable candidates in whom AKI does not resolve with specific therapy. (Hepatology 2008;48:2064-2077.)
Manufacturing and the new ANSI S2.70‐2006 hand–arm vibration exposure standard
Authors: Wasserman Donald E. 
Published: August 2008

AbstractSince 1918, hand–arm vibration (HAV) exposure, principally from but not limited to vibrating power tools and processes, affects some 1.5 to 2 million regularly exposed U.S. workers and many more worldwide. These HAV exposures usually lead to an irreversible disease of the fingers/hands called hand–arm vibration syndrome whose prevalence is as high as 50% in exposed worker populations. HAVS results not only in hand–arm deterioration, but invariably job loss. To help combat the mounting HAV problem, domestic and international consensus HAV exposure standards were developed and promulgated in the early 1980s; but for the first time, the European Union in 2005 passed into law exposure standards for both HAV and whole‐body vibration. In response, in 2006 in the United States, the American National Standards Institute (ANSI) developed, replaced, and promulgated its 1986 HAV exposure standard S3.34 with a completely revised HAV standard—S2.70‐2006—thus ushering in new profound implications for power tool users and tool manufacturers and countless related manufacturing operations throughout the United States. The background, salient aspects, safety and health, and manufacturing implications of this new ANSI S2.70 HAV standard are discussed. © 2008 Wiley Periodicals, Inc.
Hippocampal structural changes across the menstrual cycle
Authors: Protopopescu Xenia , Butler Tracy , Pan Hong , Root James , Altemus Margaret , Polanecsky Margaret , McEwen Bruce , Silbersweig David , Stern Emily 
Published: September 2008

AbstractMagnetic resonance imaging (MRI) in association with Jacobian‐modulated voxel‐based morphometry (VBM) was used to test for regional variation in gray matter over the menstrual cycle. T1‐weighted anatomical images were acquired using a spoiled gradient recalled acquisition sequence in 21 women. Each subject was scanned twice: once during the postmenstrual late‐follicular phase (Days 10–12 after onset of menses), and once during the premenstrual late‐luteal phase (1–5 days before the onset of menses). Gray matter was relatively increased in the right anterior hippocampus and relatively decreased in the right dorsal basal ganglia (globus pallidus/putamen) in the postmenstrual phase. Verbal declarative memory was increased in the postmenstrual vs. premenstrual phase. This first report of human brain structural plasticity associated with the endogenous menstrual cycle extends well‐established animal findings of hormone‐mediated hippocampal plasticity to humans, and has implications for understanding alterations in cognition and behavior across the menstrual cycle. © 2008 Wiley‐Liss, Inc.
Validation of the Learning Transfer System Inventory: A study of supervisors in the public sector in Jordan
Authors: Yaghi Abdulfattah , Goodman Doug , Holton Elwood F. , Bates Reid A. 
Published: September 2008

AbstractJordanian policymakers rely on trained supervisors to lead organizational change in public administration. The impact of training, however, remains weak unless trainees apply what they have learned (training transfer). In order to assess training transfer, the present study validates a Classic Arabic version of the Learning Transfer System Inventory (CALTSI). The instrument was administered to a random sample of 500 supervisors. Exploratory factor analysis with oblique factor rotation validates 15 of the original 16 factors of the LTSI and explains about 65% of the common variance. These findings and their implications are discussed.
A population‐based analysis of 788 cases of yolk sac tumors: A comparison of males and females
Authors: Shah Jay P. , Kumar Sanjeev , Bryant Christopher S. , Ali‐Fehmi Rouba , Malone John M. , Deppe Gunter , Morris Robert T. 
Published: September 2008

AbstractYolk sac tumors (YST) are a rare and aggressive germ cell tumor. The objective of this study is to compare the patient characteristics and survival of YST in males and females. Demographic and clinicopathologic information were obtained from the Surveillance, Epidemiology, and End Results Program from 1973 to 2003. Statistical analysis was performed using Independent‐sample t‐test, χ2 test, Kaplan‐Meier methods and Cox proportional hazards regression. Seven hundred eighty‐eight patients were identified, 451 (57%) were males and 337 (43%) were females. The mean age at diagnosis was similar in males and females. The age at diagnosis showed a bimodal distribution with an increased incidence in the first 4 years of life and during the 2nd to 4th decade of life. The most common site of the primary tumor was gonadal, namely testis 336 (42.6%) and ovary 257 (32.6%). Among the extragonadal sites, tumor site of origin differed in males and females. The 5‐year survival of extragonadal YST (66%) was worse than gonadal YST (86%) (p < 0.05). The overall median survival for the cohort was 87 months. This was similar in males (81 months) and females (91 months) (p > 0.05). As the year of diagnosis progressed from 1973 to 2003, survival of both males and females with YST consistently improved. The bimodal age distribution of YST generates the hypothesis that sex steroids may play a role in selected YST. Although the overall survival in all YST patients has improved over the past few decades, the primary sites of origin differ in males and females and impact prognosis. © 2008 Wiley‐Liss, Inc.
Incidence and geographic distribution of endemic Burkitt lymphoma in northern Uganda revisited
Authors: Ogwang Martin D. , Bhatia Kishor , Biggar Robert J. , Mbulaiteye Sam M. 
Published: September 2008

AbstractEndemic Burkitt lymphoma (BL) is etiologically associated with Epstein‐Barr virus and ecologically linked to Plasmodium falciparum malaria. However, these infections imperfectly correlate with BL epidemiology. To obtain recent epidemiological data, we studied district‐ and county‐specific BL incidence and standardized incidence ratios using data collected from 1997 to 2006 at Lacor Hospital in northern Uganda, where studies were last done more than 30 years ago. Among 500 patients, median age was 6 years (interquartile range 5–8) and male‐to‐female ratio was 1.8:1. Among those known, most presented with abdominal (56%, M:F 1.4:1) vs. only facial tumors (35%, M:F 3.0:1). Abdominal tumors occurred in older (mean age: 7.0 vs. 6.0 years; p < 0.001) and more frequently in female children (68% vs. 50%; OR 2.2, 95% CI 1.5–3.5). The age‐standardized incidence was 2.4 per 100,000, being 0.6 in 1–4 year olds, 4.1 in 5–9 year olds and 2.8 in 10–14 year olds and varied 3‐ to 4‐fold across districts. The incidence was lower in districts that were far from Lacor and higher in districts that were close to Lacor. Although districts close to Lacor were also more urbanized, the incidence was higher in the nearby perirural areas. We highlight high‐BL incidence and geographic variation in neighboring districts in northern Uganda. Although distance from Lacor clearly influenced the patterns, the incidence was lower in municipal than in surrounding rural areas. Jaw tumors were characterized by young age and male gender, but presentation has shifted away from facial to mostly abdominal. © 2008 Wiley‐Liss, Inc.
Carcinoma‐associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF‐2/FGFR‐2 axis
Authors: Giulianelli Sebastián , Cerliani Juan P. , Lamb Caroline A. , Fabris Victoria T. , Bottino María C. , Gorostiaga María A. , Novaro Virginia , Góngora Adrián , Baldi Alberto , Molinolo Alfredo , Lanari Claudia 
Published: September 2008

AbstractThe mechanisms by which mammary carcinomas acquire hormone independence are still unknown. To study the role of cancer‐associated fibroblasts (CAF) in the acquisition of hormone‐independence we used a hormone‐dependent (HD) mouse mammary tumor and its hormone‐independent (HI) variant, which grows in vivo without hormone supply. HI tumors express higher levels of FGFR‐2 than HD tumors. In spite of their in vivo differences, both tumors have the same hormone requirement in primary cultures. We demonstrated that CAF from HI tumors (CAF‐HI) growing in vitro, express higher levels of FGF‐2 than HD counterparts (CAF‐HD). FGF‐2 activated the progesterone receptors (PR) in the tumor cells, thus increasing cell proliferation in both HI and HD tumors. CAF‐HI induced a higher proliferative rate on the tumor cells and in PR activation than CAF‐HD. The blockage of FGF‐2 in the co‐cultures or the genetic or pharmacological inhibition of FGFR‐2 inhibited PR activation and tumor cell proliferation. Moreover, in vivo, the FGFR inhibitor decreased C4‐HI tumor growth, whereas FGF‐2 was able to stimulate C4‐HD tumor growth as MPA. T47D human breast cancer cells were also stimulated by progestins, FGF‐2 or CAF‐HI, and this stimulation was abrogated by antiprogestins, suggesting that the murine C4‐HI cells respond as the human T47D cells. In summary, this is the first study reporting differences between CAF from HD and HI tumors suggesting that CAF‐HI actively participate in driving HI tumor growth. © 2008 Wiley‐Liss, Inc.
Autocrine VEGF‐A/KDR loop protects epithelial ovarian carcinoma cells from anoikis
Authors: Sher Ifat , Adham Sirin A. , Petrik James , Coomber Brenda L. 
Published: September 2008

AbstractEpithelial ovarian carcinoma (EOC) patients are usually diagnosed at an advanced stage, characterized by interperitoneal carcinomatosis and production of large volumes of ascites. Vascular endothelial growth factor‐A (VEGF‐A) and its main signaling receptor VEGFR2 (KDR) are coexpressed in primary ovarian tumors, ascitic cells and metastases, suggesting the existence of an autocrine VEGF‐A/KDR loop in EOC cells. In the present study, we examined this possibility and explored the role of this autocrine loop in protecting EOC cells from apoptosis under anchorage free growth conditions (anoikis). We found that 3 different EOC cell lines (Caov3, OVCAR3, SKOV3) express both VEGF‐A and its receptors, including KDR. In these cells, KDR is constitutively phosphorylated and is detected both in the cell plasma membrane and in the nucleus. Treating EOC cells with specific internal inhibitors of KDR kinase activity or a VEGF‐A neutralizing antibody abolished KDR autophosphorylation and resulted in significant increase in apoptosis when cells were grown in single‐cell, anchorage‐free conditions. By contrast, these blocking reagents had no effect on cell viability when EOC cells were grown in adhesive monolayers. In summary, our results indicate that an autocrine VEGF‐A/KDR loop exists in EOC cells and that it plays a role in protecting the cells from anoikis. Our results imply that treating EOC patients with VEGF blocking agents may potentially reduce peritoneal dissemination by decreasing vascular permeability as well as inducing apoptosis of shed ovarian cancer cells in ascites. © 2008 Wiley‐Liss, Inc.
Frequent expression of the novel cancer testis antigen MAGE‐C2/CT‐10 in hepatocellular carcinoma
Authors: Riener Marc‐Oliver , Wild Peter J. , Soll Christopher , Knuth Alexander , Jin Boquan , Jungbluth Achim , Hellerbrand Claus , Clavien Pierre‐Alain , Moch Holger , Jochum Wolfram 
Published: September 2008

AbstractCancer testis (CT) antigens are attractive targets for immunotherapy in cancer patients. Immunohistochemistry was used to study the expression of the CT antigens MAGE‐C2/CT‐10, MAGE‐C1/CT‐7, GAGE, MAGE‐A4 and NY‐ESO‐1 in 146 hepatocellular carcinomas, 13 intrahepatic cholangiocarcinomas, 37 extrahepatic cholangiocarcinomas and 32 gallbladder carcinomas. Immunopositivity was correlated with clinicopathological parameters, MHC Class 1 expression, intratumoral CD4+, CD8+ and FOXP3+ T cells and CD163+ antigen‐presenting cells. Of the 146 hepatocellular carcinomas, 34% were positive for MAGE‐C2/CT‐10, 12% for MAGE‐C1/CT‐7, 11% for GAGE and 2% for NY‐ESO‐1, respectively. MHC Class 1 coexpression was identified in almost all CT antigen‐positive tumors. The number of intratumoral FOXP3+ regulatory T cells was increased in CT antigen‐positive hepatocellular carcinomas (p < 0.004), suggesting inhibition of immune response in such tumors. Furthermore, MAGE‐C1/CT‐7 and GAGE positivity was correlated with reduced overall survival in patients with hepatocellular carcinoma (p = 0.03 and 0.01, respectively). Four (13%) gallbladder carcinomas stained positive for MAGE‐C2/CT‐10, of which 1 tumor (3%) was also positive for NY‐ESO‐1 and GAGE. CT antigens were not expressed in intra‐ and extrahepatic cholangiocarcinomas. Our results suggest that MAGE‐C2/CT‐10 may be a good candidate for peptide vaccination in patients with hepatocellular carcinoma. © 2008 Wiley‐Liss, Inc.
P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma development
Authors: van Veelen Wendy , Klompmaker Rob , Gloerich Martijn , van Gasteren Carola J.R. , Kalkhoven Eric , Berger Ruud , Lips Cornelis J.M. , Medema Rene H. , Höppener Jo W.M. , Acton Dennis S. 
Published: September 2008

AbstractIn multiple endocrine neoplasia syndrome Type 2 (MEN2), medullary thyroid carcinoma (MTC) and pheochromocytoma (PC) are associated with hereditary activating germ‐line mutations in the RET proto‐oncogene. Also in a large percentage of sporadic MTCs and PCs, somatic RET mutations appear to be involved in tumor formation. In one single MEN2 family an extensive variety in disease expression may be observed, indicating that additional genetic events are responsible for progression of the disease towards a more aggressive phenotype. However, these additional mutations in both hereditary and sporadic MTC and PC development are largely unknown. Here, we show for the first time the presence of somatic mutations in the cell cycle regulator P18 in human RET‐associated MTCs and PCs. Each of these mutations causes an amino acid substitution in the cyclin dependent kinase‐interacting region of P18INK4C. Since these mutations partly inhibited P18INK4C function and reduced its stability, our findings implicate P18 as a tumor suppressor gene involved in human MTC and PC development. © 2008 Wiley‐Liss, Inc.
Unraveling the mysteries of protein folding and misfolding
Authors: Ecroyd Heath , Carver John A. 
Published: September 2008

AbstractThis mini‐review focuses on the processes and consequences of protein folding and misfolding. The latter process often leads to protein aggregation and precipitation with the aggregates adopting either highly ordered (amyloid fibril) or disordered (amorphous) forms. In particular, the amyloid fibril is discussed because this form has gained considerable notoriety due to its close links to a variety of debilitating diseases including Alzheimer's, Parkinson's, Huntington's, and Creutzfeldt‐Jakob diseases, and type‐II diabetes. In each of these diseases a different protein forms fibrils, yet the fibrils formed have a very similar structure. The mechanism by which fibrils form, fibril structure, and the cytotoxicity associated with fibril formation are discussed. The generic nature of amyloid fibril structure suggests that a common target may be accessible to treat amyloid fibril‐associated diseases. As such, the ability of some molecules, for example, the small heat‐shock family of molecular chaperone proteins, to inhibit fibril formation is of interest due to their therapeutic potential. © 2008 IUBMB IUBMB Life, 60(12): 769–774, 2008
Rotterdam model versus almost ideal demand system: will the best specification please stand up?
Authors: Barnett William A. , Seck Ousmane 
Published: September 2008

AbstractThe Rotterdam model and the Almost Ideal Demand System (AIDS) are often applied in consumer demand systems modeling. Using Monte Carlo techniques, we determine which model performs best in recovering the true elasticities of demand. The AIDS model is usually used in linearized form. Since the Rotterdam model is also linear in a very similar form, comparison of the Rotterdam model and the AIDS model has been the subject of much speculation in the literature. We not only compare the linearized AIDS model with the Rotterdam model, but also with the full nonlinear AIDS. Copyright © 2008 John Wiley & Sons, Ltd.
Hours per capita and productivity: evidence from correlated unobserved components models
Authors: Basistha Arabinda 
Published: September 2008

AbstractRecent studies debate the effect of a permanent productivity shock on hours per capita within a structural VAR context. This paper examines the issue using a correlated unobserved components (UC) framework. The estimates show that permanent shocks to productivity are negatively correlated with transitory shocks to hours. This result is robust for non‐stationary or levels stationary specifications of hours. Model comparisons indicate that the data do not favor imposing VAR‐type restrictions on the UC models. Copyright © 2008 John Wiley & Sons, Ltd.
Semiparametric Bayesian inference for dynamic Tobit panel data models with unobserved heterogeneity
Authors: Li Tong , Zheng Xiaoyong 
Published: September 2008

AbstractThis paper develops semiparametric Bayesian methods for inference of dynamic Tobit panel data models. Our approach requires that the conditional mean dependence of the unobserved heterogeneity on the initial conditions and the strictly exogenous variables be specified. Important quantities of economic interest such as the average partial effect and average transition probabilities can be readily obtained as a by‐product of the Markov chain Monte Carlo run. We apply our method to study female labor supply using a panel data set from the National Longitudinal Survey of Youth 1979. Copyright © 2008 John Wiley & Sons, Ltd.
Efficiency and productivity of the US banking industry, 1998–2005: evidence from the Fourier cost function satisfying global regularity conditions
Authors: Feng Guohua , Serletis Apostolos 
Published: September 2008

AbstractThis paper provides estimates of bank efficiency and productivity in the United States, over the period from 1998 to 2005, using (for the first time) the globally flexible Fourier cost functional form, as originally proposed by Gallant (1982), and estimated subject to global theoretical regularity conditions, using procedures suggested by Gallant and Golub (1984). We find that failure to incorporate monotonicity and curvature into the estimation results in mismeasured magnitudes of cost efficiency and misleading rankings of individual banks in terms of cost efficiency. We also find that the largest two subgroups (with assets greater than 1 billion in 1998 dollars) are less efficient than the other subgroups and that the largest four bank subgroups (with assets greater than $ 400 million) experienced significant productivity gains and the smallest eight subgroups experienced insignificant productivity gains or even productivity losses. Copyright © 2008 John Wiley & Sons, Ltd.
Histological reaction of sintered nanohydroxyapatite‐coated cuff and its fibroblast‐like cell hybrid for an indwelling catheter
Authors: Furuzono Tsutomu , Ueki Mitsuki , Kitamura Harumi , Oka Kazumasa , Imai Enyu 
Published: September 2008

AbstractRapid tissue‐ingrowth of a sintered hydroxyapatite(HAp)‐coated and cell‐hybrid subcutaneous cuff equipped with an indwelling catheter was developed. The rod‐like HAp nanoparticles were coated by covalent bonding on the surface of the silk fibroin (SF) fibers for about 100 μm of the length. The fibers were transplanted three‐dimensionally on a cuff substrate made of silicone elastomer with an adhesive. The fibroblast‐like cells, explanted and proliferated from skin tissue containing the epidermis, dermis, and subcutaneous tissue of Japanese white rabbits, were incubated on the three‐dimensional cuff for three days. Three types of cuff—polyester, HAp‐coated, and cell‐hybrid cuffs—were percutaneously implanted into the backs of the same animals for 3 and 7 days. The subcutaneous tissues around the cuffs were stained with hematoxylin‐eosin. Immunohistochemical staining to identify macrophages and α‐smooth muscle actin (α‐SMA) was also done and examined by light microscopy. The α‐SMA‐positive area was very limited in the polyester cuff group even after 7 days, although many macrophages infiltrated into the fibers. In the cell‐hybrid cuff group, on the other hand, an α‐SMA‐positive area was formed extensively after 3 and 7 days, causing severe inflammation. In the HAp‐coated cuff group, an α‐SMA‐positive area was formed among the fibers with little inflammation. The extent order of the α‐SMA‐positive area was cell‐hybrid cuff ≫ HAp‐coated cuff ≫ polyester cuff, while the degree of inflammatory cells order was cell‐hybrid cuff ≫ polyester cuff ≫ HAp‐coated cuff. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009