bluuebunny/crossref_metadata_2025_split huggingface dataset:
A clinical, endoscopic and pathological study of ulcer‐carcinoma: Report of 210 cases*
Authors: XU CAI‐PU , LIU FENG‐XIAN , ZHAO SHI‐MIN 
Published: March 2008

ABSTRACTA multicentre retrospective study of ulcer‐carcinoma was carried out in 16 hospitals in China, with the aim of examining the correlation between pre‐cancerous lesions and malignant change associated with benign gastric ulcer. Malignant change occurred at 2% over a variable period of 6 months to 15 years. About two‐thirds of the ulcer cancers were found to be tubular adenocarcinoma.
Induction of allogeneic tumour‐ and lymphokine‐activated lymphocytes against hepatocellular carcinoma
Authors: YASUMURA SATOSHI , HIGUCHI KIYOHIRO , HIOKI OSAMU , OKADA KAZUHIKO , TSUKISHIRO TAKASHI , TSUCHIDA TOSHIHIRO , MIYAGIWA MIKI , NAMBU SHUJI , YASUYAMA TOSHIFUMI , INOUE KYOICHI , WATANABE AKIHARU 
Published: March 2008

ABSTRACTFor clinical application of adoptive immunotherapy against hepatocellular carcinoma (HCC), it is not easy to prepare tumour specific effector cells such as cytotoxic T lymphocytes (CTL). To induce potent and broad‐spectrum effectors, allogeneic cultured hepatoma cell lines (JHH‐4 and HuH‐6) were used as stimulators of peripheral blood lymphocytes (PBL) instead of autologous HCC cells. Allogeneic tumour‐ and lymphokine‐activated killer cells (ATLAK) were generated by a mixed culture of lymphocytes and allogeneic cultured tumour cells with recombinant interleukin‐2 (rIL‐2). The tumour‐killing activity of ATLAK induced by HuH‐6 was confirmed against HuH‐6 and other different HCC cell lines (JHH‐2, HuH‐7 and PLC). These activated lymphocytes were significantly more potent than lymphokine‐activated killer cells (LAK) in [51Cr]‐releasing assay. The JHH‐4 stimulated ATLAK was reactive not only with JHH‐4 but also with JHH‐2. The lysis of allogeneic targets could be partially inhibited by anti‐CD8 and anti‐CD3 but not by anti‐CD4. Anti‐tumour cytotoxicity in these cultures might be mediated by CD3+CD56‐ and CD3+CD56+ effectors. These results imply that adoptive immunotherapy for HCC with ATLAK may be more feasible than that with LAK.
Evaluation of hepatic transport function by hepatobiliary scintigraphy
Authors: TAKIKAWA HAJIME , TOMITA JUN , SEKIYA YUSHI , MIYAKI KAZUHIKO , YAMANAKA MASAMI , NIIO YASUO , KUNIYASU YOSHIO , SUGIYAMA YUICHI 
Published: March 2008

ABSTRACTThe transport kinetics of [99mTc]‐pyridoxyl‐5‐methyltryptophan were studied by three‐compartment model analysis for hepatobiliary scintigraphy in 45 patients with chronic viral liver diseases. Three‐compartment model analysis was studied using the time‐activity curves of the regions of the heart, liver, and biliary tract and intestine (excretory compartment). The k12 (hepatic uptake rate constant), k21 (hepatic efflux rate constant), and ke1 (hepatic excretion rate constant) were calculated by the nonlinear least‐squares method. Among the three parameters obtained by model analysis, k12 values more prominently differed among diseases and correlated well with blood tests such as total bilirubin, total bile acids, or 15 min retention of ICG. In conclusion, three‐compartment model analysis of the hepatic handling of [99mTc]‐pyridoxyl‐5‐methyltryptophan is useful in evaluating hepatic transport function. k12 is the most sensitive parameter for this.
Beta‐2‐microglobulin and Helicobacter pylori infection in uraemic dialysed patients
Authors: CONZ P. A. , DANTE S. , BERNARDINI D. , BERTONCELLO V. , GRECA G. LA , BEVILACQUA P. A. 
Published: March 2008

ABSTRACTChronic gastritis in patients with chronic renal failure may have different causes and mechanisms. Recent observations suggest that severe gastritis often found in uraemic patients might be related to Helicobacter pylori (HP) infection. In chronic gastritis HP has been found in the mucus and on the epithelial cell surface of gastric foveolas. Significant infiltration of the subepithelial gastric layer by polymorphonuclear leucocytes has been described. Moreover, beta‐2‐microglobulin deposits have been found by immunohistochemical methods in the subepithelial layer of gastric mucosa of uraemic dialysed patients with active chronic gastritis and HP infection. Similar findings have also been demonstrated in gastric biopsies from patients with HP positive active chronic gastritis and normal renal function. Since HP infection is associated with significant leucocyte infiltration, it is hypothesized that the inflammatory process causes the release of beta‐2‐M from the surface of the leucocytes and its subsequent deposition at gastric level.
Hepatocellular carcinoma with an unusual papillary vesicular appearance
Authors: NG IRENE O. L. , LAI EDWARD C. S. 
Published: March 2008

ABSTRACTA resected hepatocellular carcinoma with grossly papillary, whitish cut surfaces and ‘vesicles’ in a noncirrhotic but hepatitis B surface antigen positive liver is described. This appearance has not previously been reported in the literature. Such an unusual appearance may lead to an erroneous diagnosis by both surgeons and pathologists. Histological features and possible mechanisms for the unusual gross appearance are discussed.
Long‐term follow‐up of hepatitis B vaccination in susceptible hospital personnel
Authors: CHAN CHO‐YU , LEE SHOU‐DONG , TSAI YANG‐TE , LO KWANG‐JUEI 
Published: March 2008

ABSTRACTTwo hundred and sixty‐seven susceptible hospital personnel who had been randomly divided into three groups to receive different doses (5 μg, 2 μg or 1 μg) of a plasma‐derived hepatitis B vaccine on a four‐dose schedule were investigated annually for 4 years. Of them, 251 were vaccine responders. The percentages of persistence of antibody to hepatitis B surface antigen (anti‐HBs) in these 3 groups were 95.5% (84/88), 92.3% (72/78) and 95.3% (81/85), respectively (P > 0.05). During the follow‐up period, 12 of 21 (57.1%) responders with low anti‐HBs titres (10–100 miu/mL) and 3 of 48 (6.3%) responders with medium anti‐HBs titres (101–1000 miu/mL) were found to be anti‐HBs seronegative, while none of the 182 candidates with high anti‐HBs levels (> 1000 miu/mL) lost their anti‐HBs. The 4 year cumulative rate of natural booster in the responders was 11.6% (29/251). None of the candidates became HBsAg positive during the follow‐up period. This study revealed that low dose hepatitis B vaccine can provide satisfactory immunogenic response and long‐term efficacy in Chinese adults and that the persistence of immunogenicity is not related to the vaccine dose but to the candidate's own initial anti‐HBs response.
Safety and feasibility of percutaneous ultrasound guided puncture of the gall‐bladder for crystal analysis
Authors: HOSKING S. W. , HACKING C. N. , HERBETKO J. , DEWBURY K. C. 
Published: March 2008

ABSTRACTThe safety and feasibility of ultrasound guided percutaneous aspiration (USPA) of bile, for bile crystal analysis was assessed critically. Forty‐four patients about to undergo elective cholecystectomy underwent intended transhepatic USPA 1 h before their operation. At laparotomy a careful inspection for bile and blood leakage was made and a further sample of gall‐bladder bile collected.Successful USPA occurred in 40 of the 44 patients. The four unsuccessful cases each had a gall‐bladder packed with stones and contained virtually no bile. Three patients developed bile leak after transperitoneal (n= 2) and transhepatic (n= 1) puncture of the gall‐bladder and another patient lost 100 mL of blood. Microscopic analysis of paired bile samples confirmed that gall‐bladder bile (as opposed to hepatic bile) had always been aspirated.Ultrasound guided percutaneous aspiration of bile offers a simple and promising alternative to duodenal intubation, but considerable experience is required before it can be recommended as its replacement.
Duplex‐Doppler ultrasonography in the evaluation of cirrhotic patients with portal hypertension and in the analysis of their response to drugs
Authors: CIONI GIORGIO , D'ALIMONTE PIERO , ZERBINATI FABIO , VENTURA PAOLO , CRISTANI ALESSANDRO , VIGNOLI ANNALISA , ROMAGNOLI RENATO , VENTURA EZIO 
Published: March 2008

ABSTRACTSixteen patients (15 males, aged 48–70) affected by liver cirrhosis and oesophageal varices were subjected to duplex‐Doppler ultrasonographic study (DDUS). Four patients (three with a portal thrombosis and one with a hepatofugal portal flow) were excluded from the subsequent pharmacological test. The twelve remaining patients took part in a double blind cross‐over study that evaluated the variations of heart rate (HR), mean systemic arterial pressure (SAP), portal vein diameter (PVD), maximal and mean portal flow velocity (PFV) after the administration of either 40 mg of propranolol or placebo per os, on two consecutive days. Propranolol caused no significant variation in mean SAP and in PVD, whereas it reduced the HR from 67.7±8.0 to 58.4±7.0 beats/min (mean±s.d.; P<0.001); the maxPFV dropped from 18.2±5.4 to 14.0±3.7 cm/s (P<0.001) and the meanPFV dropped from 15.3±4.1 to 13.2±3.1 cm/s (P<0.005). No significant variation was observed with placebo. After propranolol administration eight patients exhibited a significant maxPFV decrease, whereas the other four patients exhibited only a drop in HR, suggesting either drug inefficacy, inappropriate dosage or inadequate duration of treatment. DDUS is the only non‐invasive method for the examination of the portal vein system. When pharmacological treatment of portal hypertension is contemplated, DDUS is of great interest: not only does it identify the patients with portal thrombosis or hepatofugal flow (in which cases beta‐blocker therapy seems potentially dangerous and porta‐ caval shunts are not always feasible), it can also evaluate the effects of the drugs proposed on portal haemodynamics.
Duodenal ulcer in China
Authors: TOVEY F. I. 
Published: March 2008

ABSTRACTThe author visited China in 1981 and 1984 and obtained data comparing the incidence of duodenal ulcer in the rice eating districts of the south with the incidence in the wheat, maize and millet eating areas of the north. The evidence suggested a higher prevalence of duodenal ulcer in the rice eating areas than in the wheat eating areas, and a low prevalence in association with millet eating. However, the differences were less marked than between similar rice and wheat eating areas of India. It is suggested that the lower prevalence of duodenal ulcer in the wheat eating areas of north India compared with the rice eating areas of south India may be due in part to the mucosal protective effect of wheat bran in the unrefined wheat that is used in making chappatis. In China white refined flour is used in the making of steamed bread with the loss of any protective effect of wheat bran.
Multiple venous thromboses and membranous obstruction of inferior vena cava in association with hereditary protein C deficiency: A case report
Authors: DHIMAN R. K. , SARASWAT V. A. , RADHAKRISHNAN S. , PARASHAR A. , AGARWAL D. K. , NAIK S. R. 
Published: March 2008

ABSTRACTA forty year old male presented with multiple dilated venous channels over the whole body involving both inferior and superior vena caval territories, along with features of chronic liver disease and portal hypertension. On investigation, he was found to have membranous obstruction of the inferior vena cava (MOIVC) as well as obstruction of both brachiocephalic and right subclavian veins and ‘hereditary protein C deficiency'. He was managed successfully by percutaneous transluminal balloon angioplasty for the inferior vena cava (IVC) obstruction and was doing well on follow‐up.
Effects of α1 and β‐adrenergic antagonists and 5‐hydroxytryptamine receptor antagonist on portal‐systemic collateral vascular resistance in conscious rats with portal hypertension
Authors: KOSHY A. , SEKIYAMA T. , HADENGUE A. , CERINI R. , BRAILLON A. , LEBREC D. 
Published: March 2008

ABSTRACTIn order to study the acute effects of pharmacological agents on the vascular resistance of portal‐systemic collaterals, a model of total portal vein occlusion with 100% portal‐systemic shunts was developed in the conscious rat. The haemodynamic effects of several vaso‐active substances were evaluated in this model and compared with those obtained after saline administration. Prazosin (0.5 mg), an α1‐adrenergic antagonist, significantly reduced mean arterial pressure by 29%, portal pressure from 13.8 ± 1.0 (mean ± s.e.m.) to 10.1 ± 0.4 mmHg and portal tributary blood flow (radioactive microspheres) from 13.6 ± 2.1 to 11.7 ± 1.2 mL/min. It also decreased portal‐systemic vascular resistance from 95 ± 16 to 73 ± 9 dyn s/cm5 x 103. Propranolol (4 mg), a β‐adrenergic antagonist, significantly reduced mean arterial pressure by 12% and portal pressure from 15.5 ± 1.2 to 13.3 ± 0.9 mmHg while reducing portal tributary blood flow from 14.6 ± 1.5 to 11.0 ± 1.7 mL/min and increasing portal systemic collateral vascular resistance from 88 ± 7 to 103 ± 8 dyn s/cm5 x 103. Ketanserin (0.25 mg/kg), a 5‐hydroxytryptamine receptor antagonist, reduced portal pressure from 15.8 ± 1.0 to 13.3 ± 0.7 mmHg at a dose that did not alter mean arterial pressure or portal tributary blood flow. It achieved this by reducing portal‐systemic collateral vascular resistance from 90 ± 14 to 74 ± 13 dyn s/cm5 x 103. Saline had no significant effect on systemic and splanchnic haemodynamics. This study shows that ketanserin decreases vascular resistance of portal‐systemic collaterals while propranolol increases it. Thus, it is suggested that collateral vascular resistance is accessible to pharmacological manipulation.
Hypercholesterolaemia in patients with hepatocellular carcinoma
Authors: HWANG S‐J. , LEE S‐D. , CHANG C‐F. , WU J‐C. , TSAY S‐H. , LUI W‐Y. , CHIANG J‐H. , LO K‐J. 
Published: March 2008

ABSTRACTNinety‐one (11.4%) subjects with hypercholesterolaemia (serum cholesterol level more than 250 mg/dL) of 792 Chinese patients with hepatocellular carcinoma (HCC) were studied in Taiwan. All 91 patients had large tumours greater than 7 cm in diameter and a tumour volume greater than 50%; 56 (61%) of these patients manifested tumour involvement in both lobes of the liver. The HCC patients with hypercholesterolaemia had significantly higher mean serum levels of albumin, triglyceride and α‐fetoprotein (AFP) compared with age‐sex‐tumour volume matched HCC patients without hypercholesterolaemia. The associated incidence of hypoglycaemia in hypercholesterolaemic HCC patients was significantly higher than in HCC patients without hypercholesterolaemia (15/90 vs 4/90; P= 0.01). There was no significant difference in the survival analysis between HCC patients with and without hypercholesterolaemia. Eight and 11 of hypercholesterolaemic HCC patients had their tumours surgically resected and received transcatheter hepatic arterial chemoembolization (TAE), respectively. Serum cholesterol levels fell to the normal range after treatment and rose to abnormal levels again when tumours recurred after surgery or progressively enlarged after TAE. The change in pattern of serum cholesterol was parallel to the change in serum AFP. Serum cholesterol levels may serve as another marker in identifying tumour recurrence and the presence of a viable tumour mass in hypercholesterolaemic HCC patients who have received surgical resection or TAE.
Hydroxyl radical formation in human gastric juice
Authors: NALINI S. , RAMAKRISHNA B. S. , MOHANTY A. , BALASUBRAMANIAN K. A. 
Published: March 2008

ABSTRACTThe hydroxyl radical is the most potent free radical derived from oxygen, and has been implicated in damage caused to the gastroduodenal mucosa. The ability of human gastric juice to generate hydroxyl radicals has been investigated in 54 adults with endoscopically normal gastroduodenal mucosa and in 39 patients with chronic duodenal ulcer. Hydroxyl radical production was measured by the formation of formaldehyde from dimethylsulfoxide. Unlike other body fluids, this reaction could proceed without the extraneous addition of catalysts such as hydrogen peroxide (H2O2), ascorbate and iron. Measurement of H2O2, iron and ascorbate showed that these catalysts are already present in the gastric juice. There was no significant difference in the concentration of these components in gastric juice between normal subjects and patients with duodenal ulcer, except that H2O2 levels were slightly higher in duodenal ulcer patients. Although generation of free radicals has been investigated in other body fluids, this is the first reported case regarding the production of these active species in normal human gastric juice. Since hydroxyl production is not significantly enhanced in duodenal ulcer, we suggest that attention may be turned to mucosal antioxidant defences in this disease.
Correlation between CA19‐9 production in vitro and histological grades of differentiation in vivo in clones isolated from a human pancreatic cancer cell line (SUIT‐2)
Authors: IWAMURA T. , TANIGUCHI S. , KITAMURA N. , YAMANARI H. , KOJIMA A. , HIDAKA K. , SETOGUCHI T. , KATSUKI T. 
Published: March 2008

ABSTRACTThe production of carcino‐embryonic antigen (CEA) and carbohydrate antigen 19‐9 (CA19‐9) were investigated in 28 clones isolated from a human pancreatic cancer cell line (SUIT‐2) and related to in vitro morphology of the clones and in vivo tumorigenicity. Clones of fusiform and polygonal cells could be morphologically distinguished in confluent cultures. There was no significant difference in CEA production between fusiform‐cell clones (2.10 ± 2.70 ng/L x 106 per 24 h) and polygonal‐cell clones (6.01 ± 7.30 ng/L x 106 per 24 h), but polygonal‐cell clones had higher production of CA19‐9 (1176.1 ± 1628.4 U/L x 106 per 24 h) than fusiform (6.0 ± 7.3 U/L x 106 per 24 h; P < 0.01). Production of CA19‐9 in vitro correlated with the histological grade of differentiation in vivo in nude mice (r= 0.73, P < 0.001), but CEA production did not. The polygonal‐cell clones developed well‐differentiated carcinomas in vivo and produced significantly more CA19‐9 (P < 0.001) than fusiform‐cell clones, which generally developed into poorly differentiated tubular adenocarcinomas in vivo. This cell line may provide an appropriate system for further studies of the biology and therapy of pancreatic cancer.
Long‐term follow‐up of dilatation treatment of oesophageal strictures
Authors: FRASER A. G. , NICHOLSON G. I. 
Published: March 2008

ABSTRACTA review of the endoscopy records of 100 consecutive patients with oesophageal strictures was undertaken to determine the effectiveness of endoscopic dilatation therapy. The follow‐up period from presentation ranged from 6 to 72 (mean 39 months) and the symptom‐free period after the last dilatation ranged from 3 to 66 months (mean 29 months). Three hundred and fifty procedures were performed with no perforations and minimal morbidity. Eighty‐one patients who had been followed for at least 12 months since their last dilatation were free of significant dysphagia. Of these 81 patients, 77% became symptom‐free within 1 year, and 88% within 2 years. Only 35 patients required more than three dilatations; 30 patients required one dilatation and 35 required two to three dilatations. Age, sex, the presence of Barrett's oesophagus, or the oesophageal lumen diameter at presentation was not significantly correlated with outcome.
Biliary bile acids in the gall‐bladder and the common bile duct of patients with anomalous pancreaticobiliary ductal junction
Authors: SHIMADA KAZUO , CHIJIIWA KAZUO , YANAGISAWA JIRO , NAKAYAMA FUMIO 
Published: March 2008

AbstractThe high incidence of biliary tract carcinoma in patients with anomalous pancreaticobiliary ductal junction (APBDJ) with or without choledochal cyst (CC) has been well documented. Twenty‐two patients with APBDJ were divided into three groups: Group A, four patients not associated with CC and biliary tract carcinoma; Group B, 13 patients with CC but without biliary tract carcinoma; and Group C, five patients with biliary tract carcinoma (four with and one without CC). Profiles of bile acids in the gall‐bladder and/or common bile duct were analysed in these patients and compared with those in the control patients with cholecystlithiasis to examine the hypothesis that the levels of deoxycholic acid (DCA) and lithocholic acid (LCA) are elevated in patients with APBDJ because these secondary bile acids are mutagenic. Bile acids were quantified by gas—liquid chromatography. Total bile acid concentration in the gall‐bladder bile was significantly lower in any group with APBDJ than that of controls. In the gall‐bladder, increased proportion of chenodeoxycholic acid (CDCA) in Groups A and B, decreased proportion of DCA in Group B and increased proportion of cholic acid (CA) in Group C were found in bile. In the bile duct, total bile acid concentration and proportion of DCA were significantly low in bile from Group C and decreased proportion of DCA and increased proportion of CDCA were found in bile from Group B. In both the gall‐bladder and hepatic bile, proportion of LCA was not significantly different between any intergroups. Thus no increase of DCA and LCA was found in either the bile from the gall‐bladder and the bile duct of APBDJ patients. It is concluded that bile acid plays little role, if any, in the pathogenesis of biliary tract carcinoma in patients with APBDJ.
Subcutaneous seeding of small hepatocellular carcinoma after fine needle aspiration biopsy
Authors: YAMADA NOBUO , SHINZAWA HARUHIDE , UKAI KATSUAKI , WAKABAYASHI HIROTO , TOGASHI HITOSHI , TAKAHASHI TSUNEO , SEO NOBUO , ISHIYAMA SHUICHI , TSUKAMOTO MASARU , FUYAMA SHIGEMI 
Published: March 2008

AbstractUltrasonically guided fine needle (21 gauge) aspiration biopsy (FNAB) was performed on a patient with a hepatocellular carcinoma (HCC) measuring 1.5 × 1.5 cm in segment VI of the liver. The tumour was located just beneath the liver surface. Subsegmentectomy of segment VI was performed. Twelve months after the biopsy and 10 months after the operation, levels of alpha‐fetoprotein (AFP) and protein induced by Vitamin K absence or antagonist‐II (PIVKA‐II) increased gradually without any evidence of recurrence of HCC in the liver. Thirteen months after the biopsy, the patient palpated a hard subcutaneous nodule 1.5 cm in diameter in the right lower anterior chest wall at the insertion site of the biopsy needle. A subcutaneous tumour was excised and histological examination revealed moderately differentiated HCC. The levels of AFP and PIVKA‐II normalized thereafter. These tumour markers were therefore useful for diagnosing the subcutaneous nodule as a metastatic HCC. The patient is currently doing well without further recurrence of HCC or needle‐tract seeding 23 months after subsegmentectomy and 11 months after excision of the subcutaneous tumour.
Hepatocellular carcinoma in a cirrhotic liver becoming detectable within a month
Authors: EZAKI TAKAHIRO , YOSHIDA YASUNORI , OKAMURA TAKESHI , SHIRAKUSA TAKAYUKI 
Published: March 2008

AbstractA case of hepatocellular carcinoma (HCC) in a cirrhotic liver which became detectable within a month is reported here. The patient was admitted for treatment of oesophageal varices due to Child's C grade liver cirrhosis. A hepatic angiogram was performed before the treatment and showed no neovasculature. After undergoing variceal treatment by injection sclerotherapy, the patient underwent another angiogram 28 days later in order to measure the efficacy of the treatment. The second angiogram revealed the emergence of small multiple neovasculatures throughout the entire liver. From the angiographic findings, those tumours were considered to be HCC. The present report suggests that small HCC latent in a cirrhotic liver can thus acquire neovasculature within a short period of time.