bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between fibromyalgia symptoms and Fourier-transform infrared (ATR-FTIR) spectroscopy analysis of blood combined with chemometrics
Authors: Passos João Octávio Sales , Alves Marcelo Victor dos Santos , Cavalcante Antônio Felipe , Moura Shayanne , Lima Kássio MG , Pegado Rodrigo 
Published: April 2024

Abstract

Fibromyalgia typically involves pain, fatigue, and mood disruptions, often necessitating over two years and around four medical consultations for diagnosis. The combination of spectroscopy and chemometric techniques holds promise as a cost-effective and accurate strategy for screening fibromyalgia according to the association between the symptoms and spectral data. The study aimed to explore the association between spectrochemical analysis coupled to chemometric techniques with fibromyalgia symptoms. A total of 126 controls and 126 patients with fibromyalgia participated in the study. Blood plasma was analyzed using attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy in conjunction with chemometric techniques for posterior association between pain, kinesiophobia, pain catastrophizing, impact of fibromyalgia, quality of life and anxiety. The datasets underwent multivariate classification using supervised models. Different chemometric algorithms were tested to classify the spectral data and the association between symptoms. A clear accuracy discrimination was observed to moderate and severe pain (82.1%; 100%); kinesiophobia (84.6%; 80.8%), catastrophizing (87.5%; 81.8%), impact of fibromyalgia (74.8%; 77.8%), anxiety (100%; 76.9%) and mild and regular quality of life (93.2%; 81.4%). The obtained favorable classification results validate the effectiveness of this technique as an analytical tool for fibromyalgia detection.
Activation of lysosomal iron triggers ferroptosis in cancer
Authors: Rodriguez Raphaël , Cañeque Tatiana , Baron Leeroy , Müller Sebastian , Carmona Alanis , Colombeau Ludovic , Versini Antoine , Sabatier Marie , Sampaio Julio , Mishima Eikan , Picard-Bernes Armel , Solier Stéphanie , Zheng Jiashuo , Proneth Bettina , Thoidingjam Leishemba , Gaillet Christine , Grimaud Laurence , Fraser Cameron , Szylo Krystina , Bonnet Caroline , Charafe Emmanuelle , Ginestier Christophe , Santofimia Patricia , Dusetti Nelson , Iovanna Juan , Cunha Antonio Sa , Pittau Gabriella , Hammel Pascal , Tzanis Dimitri , Bonvalot Sylvie , Watson Sarah , Stockwell Brent , Conrad Marcus , Ubellacker Jessalyn 
Published: April 2024

Abstract
Iron catalyses the oxidation of lipids in biological membranes and promotes a form of cell death referred to as ferroptosis1-3. Identifying where this chemistry takes place in the cell can inform the design of drugs capable of inducing or inhibiting ferroptosis in various disease-relevant settings. Whereas genetic approaches have revealed underlying mechanisms of lipid peroxide detoxification1,4,5, small molecules can provide unparalleled spatiotemporal control of the chemistry at work6. Here, we show that the ferroptosis inhibitor liproxstatin-1 (Lip-1) exerts a protective activity by inactivating iron in lysosomes. Based on this, we designed the bifunctional compound fentomycin that targets phospholipids at the plasma membrane and activates iron in lysosomes upon endocytosis, promoting oxidative degradation of phospholipids and ferroptosis. Fentomycin effectively kills primary sarcoma and pancreatic ductal adenocarcinoma cells. It acts as a lipolysis-targeting chimera (LIPTAC), preferentially targeting iron-rich CD44high cell-subpopulations7,8 associated with the metastatic disease and drug resistance9,10. Furthermore, we demonstrate that fentomycin also depletes CD44high cells in vivo and reduces intranodal tumour growth in an immunocompetent murine model of breast cancer metastasis. These data demonstrate that lysosomal iron triggers ferroptosis and that lysosomal iron redox chemistry can be exploited for therapeutic benefits.
The Distribution and Associated Factors of SARC-F and SARC-CalF in Community-Dwelling Older Adults of Kinmen
Authors: Ho Ching-Sung , Lee Shen-Ming , Chen Meng-Chi , Lin Chia-Ming 
Published: April 2024

Abstract

Purpose
This study aims to assess the distribution of SARC-F and SARC-CalF scores and identify associated risk factors among the elderly in Kinmen.
Methods
A community-based cross-sectional study was conducted in Kinmen in 2022 at the community care stations. The sample consisted of 305 individuals aged over 65. The outcome variable was the SARC-Ca1F score, which was categorized as normal (< 11) or abnormal ( ≧ 11). Chi-square, and binary logistic regression analysis were conducted for inferential statistical analysis.
Results
A total of 3.9% exhibited abnormal SARC-F values ( ≧ 4), and 14.4% had abnormal SARC-Ca1F values ( ≧ 11). Younger age, higher educational level, and BMI ≧ 27 were independently associated with a lower abnormal rate of SARC-Ca1F scores in older adults in Kinmen. When considering the interaction effect between MNA scores, marital status, age and educational level, it was observed that single elders showed a higher abnormal rate of SARC-Ca1F values (OR = 2.299, p = 0.023). Those using Kinmenese and Chinese or solely Kinmenese had a higher abnormal rate of SARC-Ca1F values compared to others, (OR = 5.902 and OR = 9.341, respectively). Individuals with a BMI ≧ 27 exhibited a significantly lower abnormal rate of SARC-Ca1F values compared to those with a BMI falling between 22-23.99, (OR = 0.174).
Conclusions
Among the elderly population in Kinmen, individuals with younger age, higher education levels, and BMI ≧ 27 exhibit a lower prevalence of sarcopenia. Conversely, individuals who are single or use Kinmenese as their native language show a higher likelihood of developing sarcopenia, highlighting unique demographic influences.
Investigating the Impact of Beneficial Microorganisms Inoculated Cotton Plants on Spodoptera exigua
Authors: Kızılkan Nurhan Didem , Konuş Metin , Rişvanlı Mehmet Ramazan , Yılmaz Can , Kara Hilmi , Özgökçe Mehmet Salih , Çetin Doğan , Atlıhan Remzi 
Published: April 2024

Abstract
This study discusses the knowledge obtained about the plant-mediated effects of beneficial soil-borne microorganisms on survival rates, development, reproduction, and population growth parameters of Spodoptera exigua, a major cotton pest. Specifically, we examined how beneficial microorganisms impact the oxidative stress, chlorophyll content, sugar and protein levels within the cotton plant and subsequently influence the pest's population growth performance. We also evaluated the reciprocal effects of plant-insect-microorganisms interaction on total glutathione levels, glutathione S-transferase and esterase enzyme activities in S. exigua. The findings of this study revealed that there was no evidence of oxidative stress in the treated plants. However, the treated plants exhibited enhanced chlorophyll content while demonstrating reduced levels of Protein/Carbohydrate, consequently leading to a discernible decrease in the population growth performance of S. exigua. These results highlight the intricate interplay between oxidative stress, chlorophyll content, and nutritional composition, which collectively influence the population dynamics and performance of the treated plants. The concept of "host plant quality" which encompasses characteristics like nitrogen and carbon content, trace elements, and defence chemicals, played a crucial role in shaping the success of S. exigua. Changes in plant characteristics and nutrient balance can affect the performance of insects, even if they consume more leaves, leading to an increase in midgut tissue weight in S. exigua larvae. Consequently, this decrease in pest numbers is expected to enhance the plant's ability to withstand damage. Additionally, the findings from this study provided valuable insights and pertinent information regarding the intricate three-way interactions among plants, microorganisms, and pests, thereby offering potential strategies for implementing these interactions in pest management practices.
Dexamethasone compared to dexmedetomidine as parasternal block adjunct in cardiac surgery patients: an observational study.
Authors: Sepolvere Giuseppe , Sansone Pasquale , Cristiano Loredana , Sparaco Angelo , Tedesco Mario , Gagliardi Giuseppe , Costagliola Giuseppina , Scialdone Valeria Rita , Pasquariello Maria Rosaria , Zazzo Fabrizio Di , Merola Luigi , Valle Mirco Della , Galletta Roberta , Esposito Danilo , Vitale Dino Franco , De Bellis Antonio , D'Amora Mauro , Paternoster Gianluca , Erdoes Gabor , Bottazzo Leonardo Maria , Cosenza Gianluigi , Pota Vincenzo , Pace Maria Caterina , Coppolino Francesco 
Published: April 2024

Abstract

Background: Pain after cardiac surgery sternotomy is severe and compromises the respiratory mechanism leading to a delayed extubation. The parasternal block provides a long-lasting pain relief when performed with the use of adjuvants such as dexmetedomidine or dexamethasone resulting in early extubation and reduced length of stay in intensive care unit.
Methods: At the end of surgery, a bilateral superficial ultrasound parasternal block was performed with a 30 ml (15 ml per chest side) of 0.375% levobupivacaine (112,5 mg in total) Patients were allocated into two groups: patients without diabetes (n=125) received 0.1 mg/kg of dexamethasone; patients with diabetes (n= 222) received dexmedetomidine 1 mcg/kg.
Results: Weaning time from ventilator or self-reported pain severity did not show any statistically significant differences between the 2 groups. In 45.8%, VAS score 0 or no pain, was reported as early as the baseline examination 4 hours following the end of surgery. After 12 hours, this percentage rises to 97.1% up to 24 hours.
Conclusions: No statistically significant differences in postoperative cardiac surgery pain relief between dexamethasone and dexmedetomidine groups. Both dexamethasone and dexmetedomidine were effective as adjuvants on pain relief at 4 up to 24 postoperative hours. Weaning time from ventilator did not show any statistically significant differences between the two groups.
IDFequations: an R-based tool to generate intensity-duration-frequency (IDF) equations
Authors: Costa Fagner França da , Rufino Iana Alexandra Alves , de Aragão Ricardo , de Castro Marco Aurélio Holanda , Silva Rivaildo da Silva Ramos 
Published: April 2024

Abstract

IDFequations is a tool for determining intensity-duration-frequency (IDF) equations. It was specially developed to facilitate the adjustment of different probabilistic models in the frequency analysis of historical precipitation series and the adjustment of the IDF curve model without the user requiring prior knowledge about the model parameters. The tool integrates the ten most used statistical distributions to estimate maximum 1-day precipitation values for different return periods (Tr). A fitting equation was used to estimate sub-daily rainfall. The empirical parameters (k, m, t0 and n) were defined using an algorithm developed in the R programming language. It is directly connected to two precipitation database servers. It also provides IDF equations from precipitation estimation remote-sensing and local data.
Clinical Outcomes of Surgical Treatment on Myocardial Bridging in Symptomatic Patients Running Title: Surgical treatment outcomes of myocardial bridging
Authors: Zhang Boyao , Tan Mengwei , Fan Xingli , Lu Jie , Wang Guokun , Zhang Jiajun , Han Lin , Tang Yangfeng 
Published: April 2024

Abstract

Background
There is a paucity of data regarding surgical results of myocardial bridging(MB).Our study aimed to evaluate the clinical efficacy of surgical treatment including coronary artery bypass grafting (CABG) and unroofing for MB in symptomatic patients who had chest pain refractory to medical therapy..
Methods
Among 124 adult patients diagnosed with myocardial bridging at our institution(2010–2019),85 underwent surgical intervention and 39 received medical treatment.To understand the potential benefit of surgical treatment,we excluded 21 patients with concomitant operations for other diagnoses or obstructive coronary disease.64 symptomatic patients with isolated left anterior descending(LAD) MB underwent surgical treatment,which included CABG for 56 patients and unroofing for 8 patients. All patients were followed up 1 to 10 years.We analyzed recurrent symptoms,postoperative medication use,and adverse cardiovascular events.
Results
Mean age was 60.9 ± 8.4 years(48 men [75%]).All patients underwent preoperative coronary angiography.Mean cardiopulmonary bypass and cross-clamp times were 53.5 ± 19.8 minutes and 24.0 ± 10.1 minutes,respectively.During follow-up(median, 28 months) there were no cardiac-related deaths.The reintervention rate after discharge in the operation group was lower than that in the non-operation group (14.3% vs. 35.9%, p = 0.027). The symptom improvement rate of patients in the operation group was higher than that in the non-operation group (82.8% vs 48.7%, p = 0.001). Through multivariate risk analysis, we found that antiplatelet strategies (p = 0.004, OR = 0.187, 95%CI = 0.059–0.594) were risk factors for graft restenosis in patients with CABG.
Conclusions
Surgical treatment can be performed safely and effectively in patients with chest pain and isolated LAD coronary artery myocardial bridging.However,patients should be aware of the potential for recurrent chest pain, and continued medical therapy was important.
The implications of social relationships for depressive symptoms in community-dwelling older adults: Results from the Korea Community Health Survey
Authors: Lee Ji Eun , Kim Seonji , Lee Jeehye , Hong Yun-Chul , Lee Kyung-Shin , Min Hye Sook 
Published: April 2024

Abstract

Background
Epidemiological findings have established a strong link between social relationships and mental health in older populations. However, a comprehensive exploration within diverse social contexts is warranted. This study aimed to identify the connections between social relationship and depressive symptoms among older adults in South Korea.
Methods
The 2017 and 2019 Korea Community Health Surveys were used to analyze 85,861 adults aged 65 years and older. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9). A single question was used to measure gloom. Social contact, social activity, and perception of neighborhood served as variables related to social relationships. Associations were analyzed using hierarchical logistic regression.
Results
Among the participants, 5,632 (6.5%) experienced gloom and 3,770 (4.3%) had depressive symptoms. In the multivariate analyses, older adults with good social contact, social activity, and perception of neighborhood were less likely to be depressive. Additionally, participants were less likely to be depressed if they had a higher income, worked, slept longer hours, had higher education, consumed alcohol, and were physically active. Good social contact was robustly associated with fewer depressive symptoms in the lowest income subgroup.
Discussion
This study showed a close link between social relationships and depressive symptoms in older adults, highlighting the significance of social contact in low-income groups. A social context-based approach should be considered to prevent depression in older adults.
Experimental and parametric analysis of friction stir welding on AA 8011-H14 using multi-objective Taguchi-based grey relational analysis for structural applications
Authors: Radj B. Magamai , Natarajan Sendhil Kumar , Vasudevan Gopi 
Published: April 2024

Abstract

In this study, Taguchi grey relational analysis (GRA) is employed to optimize process parameters in a multi-objective fashion, aiming to maximize the mechanical characteristics of a 2-mm-thick friction stir-welded AA 8011-H14 aluminum alloy sheet. The experimental design utilized Taguchi's L9 factorial design, varying tool penetration depth, feed speed, and tool rotational speed. The study evaluated output responses, including ultimate tensile strength, yield strength, percentage elongation, and microhardness in the welded region. Macro and microstructure analyses were conducted on the optimized joints at different locations within the welded region. The impact of process parameters on GRA was investigated through analysis of variance. Results indicated that tool rotational speed exerted the most significant influence, followed by tool penetration depth and feed speed, in terms of enhancing output responses. The study also quantified the percentage contribution of each process parameter to friction stir welding.
Doubly Reflected Backward SDEs Driven by G-Brownian Motions and Fully Nonlinear PDEs with Double Obstacles
Authors: Li Hanwu , Ning Ning 
Published: April 2024

Abstract
In this paper, we introduce a new method to study the doubly reflected backward stochastic differential equation driven by G-Brownian motion (G-BSDE). Our approach involves approximating the solution through a family of penalized reflected G-BSDEs with a lower obstacle that are monotone decreasing. By employing this approach, we establish the well-posedness of the solution of the doubly reflected G-BSDE with the weakest known conditions, and uncover its relationship with the fully nonlinear partial differential equation with double obstacles for the first time.
Family member and service provider experiences and perspectives of a digital surveillance and service navigation approach: A qualitative study with a culturally diverse community
Authors: Barr Karlen R. , Hawker Patrick , Winata Teresa , Wang Si , Smead Melissa , Ignatius Hilda , Kohlhoff Jane , Schmied Virginia , Jalaludin Bin , Lawson Kenny , Liaw Siaw-Teng , Lingam Raghu , Page Andrew , Lam-Cassettari Christa , Boydell Katherine , Lin Daniel P. , Katz Ilan , Dadich Ann , Raman Shanti , Grace Rebecca , Doyle Aunty Kerrie , McClean Tom , Mento Blaise Di , Preddy John , Woolfenden Susan , Eapen Valsamma 
Published: April 2024

Abstract

Background
Children and families from priority populations experienced significant psychosocial and mental health issues to the COVID-19 pandemic. Yet they also faced significant barriers to service access, particularly families from culturally and linguistically diverse (CALD) backgrounds. With most child and family health nurse clinics ceasing in-person consultations due to the pandemic, many children missed out on health and developmental checks. The aim of this study was to investigate the perspectives and experiences of family members and service providers from an urban, CALD community regarding the implementation of a digital, developmental surveillance, Watch Me Grow-Electronic (WMG-E) program.
Methods
Semi-structured interviews were conducted with 17 family members, service navigators, and service providers in a multicultural community in South Western Sydney, Australia. This qualitative study formed part of a larger, two-site, randomised controlled trial of the WMG-E program. A reflexive thematic analysis approach was adopted to analyse the data.
Results
Participants highlighted the comprehensive and personalised support offered by existing child and family health services. The WMG-E was deemed beneficial because the weblink was easy and quick to use and it enabled access to a service navigator who support family access to relevant services. However, the WMG-E was problematic because of technology or language barriers, and it did not facilitate immediate clinician involvement when families completed the weblink.
Conclusions
Families and service providers found that using WMG-E empowered parents and caregivers to access developmental screening and learn more about their child’s development and engage with relevant services. This beds down a new and innovative solution to the current service delivery gap and create mechanisms that can engage families currently not accessing services, and develops and increases knowledge around navigating the health and social care services.
Trial registration:
The study is part of a large randomised controlled trial (Protocol No. 1.0, Version 3.1) was registered with ANZCTR (registration number: ACTRN12621000766819) on July 21st, 2021 and reporting of the trial results will be according to recommendations in the CONSORT Statement.
Creating subject competence translation tests with GPT-4: A case study in English-to-Turkish translations in the engineering domain
Authors: Sánchez-Torrón Marina , Ipek Egemen , Raído Vanessa Enríquez 
Published: April 2024

Abstract

As Machine Translation (MT) technologies become more advanced, the translation errors they generate are often increasingly subtle. When MT is integrated in ‘Human-in-the-Loop’ (HITL) translation workflows for specialized domains, successful Post-Editing (PE) hinges on the humans involved having in-depth subject competence, as knowledge of the specific terminology and conventions are essential to produce accurate translations. One way of assessing an individual’s expertise is through manual translation tests, a method traditionally used by Language Service Providers (LSPs) and translator educators alike. While manual evaluation can provide the most comprehensive overview of a translator’s abilities, they have the disadvantage of being time-consuming and costly, especially when large numbers of subjects and language pairs are involved. In this work, we report on the experience of creating automated tests with GPT-4 for subject competence assessment in the translation of English-to-Turkish engineering texts in HITL translation workflows. While there may be a level of usefulness in the resulting tests, they are not fit for direct implementation without further refinement.
An inertial self-adaptive algorithm for solving split feasibility problems and fixed point problems in the class of demicontractive mappings
Authors: Berinde Vasile 
Published: April 2024

Abstract
We propose a hybrid inertial self-adaptive algorithm for solving the split feasibility problem and fixed point problem in the class of demicontractive mappings. Our results are very general and extend several related results existing in literature from the class of nonexpansive or quasi-nonexpansive mappings to the larger class of demicontractive mappings. Examples to illustrate numerically the effectiveness of the new analytical results are presented.
Evaluation of the seismic susceptibility in the north of morocco considering the soil-structure interaction
Authors: janous soumaya el , Ghoulbzouri Abdelouafi El 
Published: April 2024

Abstract
Due to its geographical location, Morocco is situated on the northwest edge of the African plate, which is continuously moving towards and colliding with the Eurasian plate. This movement makes Morocco a country with moderate seismic activity, occasionally resulting in destructive earthquakes reaching a magnitude close to 6.5 (2004 Al Hoceima earthquake). The application of seismic building codes to new constructions has been mandatory in Morocco since 2002 for nearly all buildings located in areas other than Zone 0. However, there is no obligation for preventive strengthening concerning existing buildings. Yet, the seismic vulnerability of these structures can be quite high, and in the most exposed areas, significant loss of human life could be caused by high-intensity earthquakes. Seismic prevention must naturally be complemented by methods to determine the damage to a structure and, consequently, its vulnerability. Therefore, the objective of this contribution is to study the seismic performance and identify the levels of damage in reinforced concrete structures in the city of Al Hoceima, taking into account the nonlinear behavior of the structures and considering soil-structure interaction.