bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors influencing the fate of chemical food safety hazards in the terrestrial circular primary food production system—A comprehensive review
Authors: Huang Weixin , Focker Marlous , van Dongen Katja C. W. , van der Fels ‐ Klerx H. J. 
Published: March 2024

AbstractFood safety is recognized as a major hurdle in the transition toward circular food production systems due to the potential reintroduction and accumulation of chemical contaminants in these food systems. Effectively managing these hazardous contaminants in a risk‐based manner requires quantitative insights into the factors influencing the presence and fate of contaminants in the entire circular food chain. A systematic literature review was performed to gain an up‐to‐date overview of the known factors and their influence on the transfer and accumulation of contaminants. This review focused on the terrestrial circular primary food production system, including the pathways between waste‐ or byproduct‐based fertilizers, soil, crops, animal feed, and farmed animals. This review revealed an imbalance in research regarding the different pathways: studies on the soil‐to‐crop pathway were most abundant. The factors identified can be categorized as compound‐related (intrinsic) factors, such as hydrophobicity, molecular weight, and chain length, and extrinsic factors, such as soil organic matter and carbon, pH, milk yield of cows, crop age, and biomass. Quantitative data on the influence of the identified factors were limited. Most studies quantified the influence of individual factors, whereas only a few studies quantified the combined effect of multiple factors. By providing a holistic insight into the influential factors and the quantification of their influence on the fate of contaminants, this review contributes to the improvement of food safety management for chemical hazards when transitioning to a circular food system.
Massive continuous irrigation (MCI) and endoscopic debridement as an alternative treatment strategy for refractory abscess‐fistula complexes
Authors: Zhao Yue , Zhang Ji Yu , Ullah Saif , Zheng Qing Fen , Liu Dan , Wang Meng , Zhao Li Xia , Shi Miao , Li De Liang , Liu Bing Rong 
Published: March 2024

ObjectiveTo evaluate the feasibility, safety, and efficacy of massive continuous irrigation (MCI) and endoscopic debridement for the treatment of refractory abscess–fistula complexes.MethodsThis was a retrospective single‐center observational study involving 12 patients with refractory abscess–fistula complexes. All patients had experienced long‐term treatment failure or had failed multiple treatment modalities. We used over two catheters and inserted them via the gastrointestinal (GI) tract or percutaneously to form a circulation pathway to achieve MCI of normal saline, endoscopic debridement was then performed. The treatment success rate, irrigation volume and treatment duration, time to abscess–fistula complex closure, intra‐treatment complications, and recurrence rate were recorded.ResultsThe treatment success rates were 100%. The median time of previous treatment was 32 days (range 7–912 days). The mean time from the use of the novel treatment strategy to abscess–fistula complex healing was 18.8 ± 11.0 days. The mean volume of irrigation was 10 804 ± 1669 mL/24 h. The mean irrigation time was 16.5 ± 9.2 days, and a median of two irrigation tubes (range 2–5) were used. No complications occurred either during or after the procedure. During the follow‐up of 23.1 ± 18.1 months, no recurrence or adverse events were noted.ConclusionsMCI and endoscopic debridement may be a feasible, safe, and effective alternative treatment for refractory abscess–fistula complexes. Large prospective studies are needed to validate our results.
Using Drosophila amyloid toxicity models to study Alzheimer's disease
Authors: Tsintzas Elli , Niccoli Teresa 
Published: March 2024

AbstractAlzheimer's disease (AD) is the most prevalent form of dementia and is characterised by a progressive loss of neurons, which manifests as gradual memory decline, followed by cognitive loss. Despite the significant progress in identifying novel biomarkers and understanding the prodromal pathology and symptomatology, AD remains a significant unmet clinical need. Lecanemab and aducanumab, the only Food and Drug Administration approved drugs to exhibit some disease‐modifying clinical efficacy, target Aβ amyloid, underscoring the importance of this protein in disease aetiology. Nevertheless, in the absence of a definitive cure, the utilisation of preclinical models remains imperative for the identification of novel therapeutic targets and the evaluation of potential therapeutic agents. Drosophila melanogaster is a model system that can be used as a research tool to investigate neurodegeneration and therapeutic interventions. The short lifespan, low price and ease of husbandry/rearing make Drosophila an advantageous model organism from a practical perspective. However, it is the highly conserved genome and similarity of Drosophila and human neurobiology which make flies a powerful tool to investigate neurodegenerative mechanisms. In addition, the ease of transgenic modifications allows for early proof of principle studies for future therapeutic approaches in neurodegenerative research. This mini review will specifically focus on utilising Drosophila as an in vivo model of amyloid toxicity in AD.
“Completely Free”: How a Subsumption of Labour and Nature Framework Explains the Surprising Expressions of “Freedom” by Immigrant Worm pickers in Ontario
Authors: Steckley Joshua 
Published: March 2024

AbstractCanadian nightcrawler (Lumbricus terrestris) worms, the most popular live bait for recreational freshwater anglers, are hand‐picked from Ontario dairy farmers’ fields by an immigrant labour force working in the middle of the night with limited equipment. Though no picker enjoys the arduous activity of picking worms, they do express feelings of “freedom” and “autonomy” in the job. Such expressions are surprising coming from mostly non‐English‐speaking immigrants, labouring with bent backs under dreary conditions producing profit for their employers in an unregulated industry. To understand these counterintuitive conceptions of freedom, I connect debates around “un/free labour” and “constrained agency” with the Marxist concepts of formal and real subsumption of labour and nature to reveal how the ecological conditions of commodity production shape capitalist control over labour. I argue worm‐picker agency should be understood by seeing how the subsumption of labour is related to the subsumption of nature.
Machine learning‐based nomogram to predict poor response to overnight orthokeratology in Chinese myopic children: A multicentre, retrospective study
Authors: Tang Wenting , Li Jiaqian , Fu Xuelin , Lin Quan , Zhang Li , Luo Xiangning , Zhao Wenjing , Liao Jia , Xu Xinyue , Wang Xiaoqin , Zhang Huidan , Li Jing 
Published: March 2024

AbstractPurposeTo develop and validate an effective nomogram for predicting poor response to orthokeratology.MethodsMyopic children (aged 8–15 years) treated with orthokeratology between February 2018 and January 2022 were screened in four hospitals of different tiers (i.e. municipal and provincial) in China. Potential predictors included 32 baseline clinical variables. Nomogram for the outcome (1‐year axial elongation ≥0.20 mm: poor response; <0.20 mm: good response) was computed from a logistic regression model with the least absolute shrinkage and selection operator. The data from the First Affiliated Hospital of Chengdu Medical College were randomly assigned (7:3) to the training and validation cohorts. An external cohort from three independent multicentre was used for the model test. Model performance was assessed by discrimination (the area under curve, AUC), calibration (calibration plots) and utility (decision curve analysis).ResultsBetween January 2022 and March 2023, 1183 eligible subjects were screened from the First Affiliated Hospital of Chengdu Medical College, then randomly divided into training (n = 831) and validation (n = 352) cohorts. A total of 405 eligible subjects were screened in the external cohort. Predictors included in the nomogram were baseline age, spherical equivalent, axial length, pupil diameter, surface asymmetry index and parental myopia (p < 0.05). This nomogram demonstrated excellent calibration, clinical net benefit and discrimination, with the AUC of 0.871 (95% CI 0.847–0.894), 0.863 (0.826–0.901) and 0.817 (0.777–0.857) in the training, validation and external cohorts, respectively. An online calculator was generated for free access (http://39.96.75.172:8182/#/nomogram).ConclusionThe nomogram provides accurate individual prediction of poor response to overnight orthokeratology in Chinese myopic children.
A longitudinal study of societal resilience and its predictors during the Israel‐Gaza war
Authors: Kaim Arielle , Tov Maya Siman , Kimhi Shaul , Marciano Hadas , Eshel Yohanan , Adini Bruria 
Published: March 2024

AbstractThis study assesses the resilience of Israeli society during the ongoing Israel‐Gaza conflict and pinpoints factors that influence this resilience in prolonged national crises. A longitudinal study was carried out with two surveys, both using the same questionnaire to gage societal, community, and individual resilience levels, along with hope, morale, distress, perceived threats, and government support. The initial survey was administered 5 days after the war escalated and the second 1 month later. The study's results reveal a decline in societal resilience over time. The regression analysis identified four major associations at both resilience measurement points. The key variables are community resilience and hope, both contributing positively. Attitudes towards government support (specifically being a government supporter vs. an opponent) also played a role. Additionally, there was a negative association with levels of religiosity, particularly distinguishing between ultra‐orthodox and secular individuals. In the temporal analysis predicting future resilience (from data at the first time point to predict resilience at the second time point), societal resilience at the first measurement was the strongest forecaster of its resilience at the second measurement. Additionally, the main continuous variable from the previous analysis, community resilience, continued to be an influential and positive forecaster in the time‐based analysis. The research suggests that the initial unifying effect of the conflict, similar to a “Rally around the flag” phenomenon, may be short‐lived. The study underlines the importance of community strength, hope, government support, and religious considerations in shaping societal resilience in the face of conflict.
“From All, To All”: Implementing a collaborative online conference to reflect on the daily living of individuals with cerebral palsy
Authors: Vieira Beatriz S. , Airoldi Marina J. , Chalfun Deborah , Bonfim Rafael G. A. S. , Teplicky Rachel , Rosenbaum Peter , Mancini Marisa C. , Brandão Marina B. 
Published: March 2024

AbstractBackgroundTranslating knowledge to improve paediatric rehabilitation has become a research area of interest. This study describes the development and evaluation of an online conference that brought together perspectives of individuals with cerebral palsy (CP), families, health care professionals, and researchers to discuss the daily living of individuals with CP.MethodsWe anchored the development and implementation of the online conference in the action cycle of the Knowledge to Action Framework. To develop the meeting, we included representatives from each stakeholder group in the programme committee. The conference programme was designed having the lifespan perspective of individuals with CP, from birth to adulthood, as its central core, with themes related to daily living (e.g., self‐care, mobility, and continuing education). Participants' satisfaction with the conference was assessed using an anonymized online survey sent to all participants.ResultsThe conference had 1656 attendees, of whom 675 answered the online satisfaction survey. Most participants rated the structure of the conference (i.e., quality of the technical support, audio and video, and online platform) and discussed topics (i.e., relevance, content, discussion, speakers, and available time) positively.ConclusionCollaborative conferences that include stakeholders throughout the planning and implementation are a viable, effective knowledge translation strategy that allows for sharing experiences and disseminating knowledge among families and individuals with CP, health care professionals, and researchers.
The role of Afrocultural ethos in African American youth's emotion skill development
Authors: Lozada Fantasy T. 
Published: March 2024

AbstractResearch on African American youth's emotional development provides an incomplete understanding of the cultural influences that shape emotion‐related skills such as emotion expression, regulation, and understanding. In this article, I propose the multiple cultural frameworks of triple quandary theory to characterize the nature of mainstream cultural experiences and minority cultural experiences in current research on emotional development in African American youth. I also discuss Afrocultural ethos as an aspect of African American cultural experiences that shapes African American emotional development, using affect and orality as examples that can be explored and embedded within emotional development research. Finally, I describe important factors for researchers to consider in the study of Afrocultural ethos in affective developmental science.
Accuracy of robotic surgery for dental implant placement: A systematic review and meta‐analysis
Authors: Wu Xin‐Yu , Shi Jun‐Yu , Qiao Shi‐Chong , Tonetti Maurizio S. , Lai Hong‐Chang 
Published: March 2024

AbstractObjectivesTo systematically analyze the accuracy of robotic surgery for dental implant placement.Materials and MethodsPubMed, Embase, and Cochrane CENTRAL were searched on October 25, 2023. Model studies or clinical studies reporting the accuracy of robotic surgery for dental implant placement among patients with missing or hopeless teeth were included. Risks of bias in clinical studies were assessed. Meta‐analyses were undertaken.ResultsData from 8 clinical studies reporting on 109 patients and 242 implants and 13 preclinical studies were included. Positional accuracy was measured by comparing the implant plan in presurgery CBCT and the actual implant position in postsurgery CBCT. For clinical studies, the pooled (95% confidence interval) platform deviation, apex deviation, and angular deviation were 0.68 (0.57, 0.79) mm, 0.67 (0.58, 0.75) mm, and 1.69 (1.25, 2.12)°, respectively. There was no statistically significant difference between the accuracy of implants placed in partially or fully edentulous patients. For model studies, the pooled platform deviation, apex deviation, and angular deviation were 0.72 (0.58, 0.86) mm, 0.90 (0.74, 1.06) mm, and 1.46 (1.22, 1.70)°, respectively. No adverse event was reported.ConclusionWithin the limitation of the present systematic review, robotic surgery for dental implant placement showed suitable implant positional accuracy and had no reported obvious harm. Both robotic systems and clinical studies on robotic surgery for dental implant placement should be further developed.
Intracerebral hemorrhage‐induced brain injury in mice: The role of peroxiredoxin 2‐Toll‐like receptor 4 inflammatory axis
Authors: Du Yang , Wang Jinjin , Zhang Jia , Li Ning , Li Guangshuo , Liu Xinmin , Lin Yijun , Wang Dandan , Kang Kaijiang , Bian Liheng , Zhao Xingquan 
Published: March 2024

AbstractBackgroundPeroxiredoxin 2 (Prx2), an intracellular protein that regulates redox reactions, released from red blood cells is involved in inflammatory brain injury after intracerebral hemorrhage (ICH). Toll‐like receptor 4 (TLR4) may be crucial in this process. This study investigated the role of the Prx2‐TLR4 inflammatory axis in brain injury following experimental ICH in mice.MethodsFirst, C57BL/6 mice received an intracaudate injection of autologous arterial blood or saline and their brains were harvested on day 1 to measure Prx2 levels. Second, mice received an intracaudate injection of either recombinant mouse Prx2 or saline. Third, the mice were co‐injected with autologous arterial blood and conoidin A, a Prx2 inhibitor, or vehicle. Fourth, the mice received a Prx2 injection and were treated with TAK‐242, a TLR4 antagonist, or saline (intraperitoneally). Behavioral tests, magnetic resonance imaging, western blot, immunohistochemistry/immunofluorescence staining, and RNA sequencing (RNA‐seq) were performed.ResultsBrain Prx2 levels were elevated after autologous arterial blood injection. Intracaudate injection of Prx2 caused brain swelling, microglial activation, neutrophil infiltration, neuronal death, and neurological deficits. Co‐injection of conoidin A attenuated autologous arterial blood‐induced brain injury. TLR4 was expressed on the surface of microglia/macrophages and neutrophils and participated in Prx2‐induced inflammation. TAK‐242 treatment attenuated Prx2‐induced inflammation and neurological deficits.ConclusionsPrx2 can cause brain injury following ICH through the TLR4 pathway, revealing the Prx2‐TLR4 inflammatory axis as a potential therapeutic target.
Ischemia‐induced cardiac dysfunction is exacerbated in adiponectin‐knockout mice due to impaired autophagy flux
Authors: Sung Hye Kyoung , Tang Jialing , Jahng James Won Suk , Song Erfei , Chan Yee Kwan , Lone Abdul Hadee , Peterson Jeffrey , Abdul‐Sater Ali , Sweeney Gary 
Published: March 2024

AbstractStrategies to enhance autophagy flux have been suggested to improve outcomes in cardiac ischemic models. We explored the role of adiponectin in mediating cardiac autophagy under ischemic conditions induced by permanent coronary artery ligation. We studied the molecular mechanisms underlying adiponectin's cardio‐protective effects in adiponectin knockout (Ad‐KO) compared with wild‐type (WT) mice subjected to ischemia by coronary artery ligation and H9c2 cardiomyocyte cell line exposed to hypoxia. Systemic infusion of a cathepsin‐B activatable near‐infrared probe as a biomarker for autophagy and detection via noninvasive three‐dimensional fluorescence molecular tomography combined with computerized tomography to quantitate temporal changes, indicated increased activity in the myocardium of WT mice after myocardial infarction which was attenuated in Ad‐KO. Seven days of ischemia increased myocardial adiponectin accumulation and elevated ULK1/AMPK phosphorylation and autophagy assessed by Western blotting for LC3 and p62, an outcome not observed in Ad‐KO mice. Cell death, assessed by TUNEL analysis and the ratio of Bcl‐2:Bax, plus cardiac dysfunction, measured using echocardiography with strain analysis, were exacerbated in Ad‐KO mice. Using cellular models, we observed that adiponectin stimulated autophagy flux in isolated primary adult cardiomyocytes and increased basal and hypoxia‐induced autophagy in H9c2 cells. Real‐time temporal analysis of caspase‐3/7 activation and caspase‐3 Western blot indicated that adiponectin suppressed activation by hypoxia. Hypoxia‐induced mitochondrial reactive oxygen species production and cell death were also attenuated by adiponectin. Importantly, the ability of adiponectin to reduce caspase‐3/7 activation and cell death was not observed in autophagy‐deficient cells generated by CRISPR‐mediated deletion of Atg7. Collectively, our data indicate that adiponectin acts in an autophagy‐dependent manner to attenuate cardiomyocyte caspase‐3/7 activation and cell death in response to hypoxia in vitro and ischemia in mice.
Practical strategies to manage obesity in type 2 diabetes
Authors: Rodbard Helena W. , Barnard‐Kelly Katharine , Pfeiffer Andreas F. H. , Mauersberger Carina , Schnell Oliver , Giorgino Francesco 
Published: March 2024

AbstractThe rising phenomenon of obesity, a major risk factor for the development and progression of type 2 diabetes, is a complex and multifaceted issue that requires a comprehensive and coordinated approach to be prevented and managed. Although novel pharmacological measures to combat obesity have achieved unprecedented efficacy, a healthy lifestyle remains essential for the long‐term success of any therapeutic intervention. However, this requires a high level of intrinsic motivation and continued behavioural changes in the face of multiple metabolic, psychological and environmental factors promoting weight gain, particularly in the context of type 2 diabetes. This review is intended to provide practical recommendations in the context of a holistic, person‐centred approach to weight management, including evidence‐based and expert recommendations addressing supportive communication, shared decision‐making, as well as nutritional and pharmacological therapeutic approaches to achieve sustained weight loss.
Chronic kidney disease and outcomes in hospitalized sickle cell disease patients: A National Inpatient Sample analysis
Authors: Ajibawo Temitope , Okunowo Oluwatimilehin 
Published: March 2024

AbstractObjectivesTo examine the association between chronic kidney disease (CKD) and outcomes in sickle cell disease (SCD) patients.MethodsPatients ≥18 years with SCD in the National Inpatient Sample database between 2016 and 2018 were identified using ICD‐10‐CM diagnosis codes. A 1:1 propensity‐score matched analysis was performed to compare in‐hospital outcomes of patients with and without CKD.ResultsOf the 366 240 SCD admissions, 19 365 (5.3%) had CKD. The CKD group had higher odds of in‐hospital mortality (odds ratio [OR] 2.59, 95% confidence interval [CI]: 1.63–4.12, p = <.01), blood transfusion (OR 1.67, 95% CI: 1.47–1.90, p < .01), mechanical ventilation (OR 2.20, 95% CI: 1.56–3.12, p = <.01), sepsis (OR 1.75, 95% CI: 1.46–2.10, p < .01), incurred higher costs ($53 255 vs. $47 294, p < .001), but had lower odds of acute chest syndrome (OR 0.71, 95% CI: 0.54–0.95, p = 0.02) and pulmonary embolism (OR 0.45, 95% CI: 0.31–0.67, p < .01).ConclusionsCKD was associated with higher mortality, higher costs, blood transfusion, sepsis, and mechanical ventilation in SCD patients. Further studies are needed to explore the reasons for the reduced odds of pulmonary embolism and acute chest syndrome.
The plant root economics space in relation to nutrient limitation in Eurasian herbaceous plant communities
Authors: Scheifes Daniil J. P. , te Beest Mariska , Olde Venterink Harry , Jansen André , Kinsbergen Daan T. P. , Wassen Martin J. 
Published: March 2024

AbstractPlant species occupy distinct niches along a nitrogen‐to‐phosphorus (N:P) gradient, yet there is no general framework for belowground nutrient acquisition traits in relation to N or P limitation. We retrieved several belowground traits from databases, placed them in the “root economics space” framework, and linked these to a dataset of 991 plots in Eurasian herbaceous plant communities, containing plant species composition, aboveground community biomass and tissue N and P concentrations. Our results support that under increasing N:P ratio, belowground nutrient acquisition strategies shift from “fast” to “slow” and from “do‐it‐yourself” to “outsourcing”, with alternative “do‐it‐yourself” to “outsourcing” strategies at both ends of the spectrum. Species' mycorrhizal capacity patterns conflicted with root economics space predictions based on root diameter, suggesting evolutionary development of alternative strategies under P limitation. Further insight into belowground strategies along nutrient stoichiometry is crucial for understanding the high abundance of threatened plant species under P limitation.