bluuebunny/crossref_metadata_2025_split huggingface dataset:
आरुको बोट कथामा शृङगार रस
Authors: भुसाल Bhusal राजु  Raju 
Published: February 2025

प्रस्तुत लेख पदमावती सिंहद्वारा रचना गरिएको ‘आरुको बोट’ कथामा अभिव्यक्त शृङगार रसको अध्ययनमा केन्द्रित छ । यसमा रसको सैद्धान्तिक परिचयका साथै रस विधायक तत्व—विभाव, अनुभाव, व्यभिचारी भाव र स्थायी भावको चर्चा गर्दै यसका आधारमा प्रस्तुत कथाको विश्लेषण गरिएको छ । यस क्रममा प्रस्तुत कथामा आएका मुख्यमुख्य सातवटा मोडहरूलाई सात उपशीर्षकमा राखेर अध्ययन गरिएको छ । जवानीको रङ्ग चढदै गएकी यस कथाकी प्रमुख पात्र रश्मिलाई केन्द्र बनाएर लेखिएको यस कथामा रजस्वलाको एघार दिन गुप्तबास बसेको बेलामा उसमा देखिएको भाव—तरङ्गहरूलाई अत्यन्त सूक्ष्मरूपमा निरीक्षण गरिएको छ । रजस्वलाभन्दा अगाडि विपरीत लिङ्गीप्रतिको आकर्षण रश्मिमा नदेखिएको र रजस्वलापछि उसमा त्यसप्रकारको भावना विकसित हँुदै गइरहेको सन्दर्भ देखाएर यस कथालाई रति स्थायी भावलाई जागृत गर्ने श्रृङ्गारमूलक कथा हो भन्ने निष्कर्ष यस लेखमा निकालिएको छ ।
Comportamiento de sobrepeso-obesidad con parámetros bioquímicos antes y durante la pandemia COVID-19 en jóvenes universitarios.
Authors: Trejo-Sánchez Blanca Estela , Sánchez-Barragan Baldómero , Romero-Vázquez Argeo , González-Garrido José Arnold 
Published: February 2025

Introducción. La obesidad es un factor de riesgo en el desarrollo de complicaciones graves por SARS-CoV-2, al igual que en enfermedades crónicas como la diabetes mellitus tipo 2 y la hipertensión. Sin embargo, el único padecimiento que puede revertirse es la obesidad, disminuyendo la inflamación y fortaleciendo el sistema inmune. Objetivo. Conocer el comportamiento de sobrepeso-obesidad con parámetros bioquímicos antes y durante la pandemia COVID-19 en jóvenes universitarios. Material y métodos. Se realizó un estudio observacional transversal analítico con datos de antes de la pandemia (2015-2017) y durante la pandemia (2021) de estudiantes universitarios (n= 5886) con edad promedio de 18 años, del Campus Chontalpa de la Universidad Juárez Autónoma de Tabasco. El IMC se calculó con base en los criterios establecidos por la OMS. Resultados. En pandemia se incrementaron la prevalencia de sobrepeso-obesidad (7.1% en hombres y 5.5% en mujeres) y la de su CA (14.4% en hombres y 4.3% en mujeres) con fuerte correlación de estas dos variables en ambos periodos, en ambos sexos y observando incremento mayor en pandemia en las mujeres (0.088) que en los hombres (0.033), comparado con los resultados de prepandemia. Se observó incremento en parámetros bioquímicos en pandemia con respecto a la prepandemia, en mujeres de glucosa (4%) y de colesterol en hombres (5.6%), sin embargo, en los triglicéridos hubo disminución en ambos sexos. Conclusión. El comportamiento de sobrepeso-obesidad indica incremento de los marcadores bioquímicos de riesgo metabólico en el periodo de pandemia respecto de la prepandemia.
PERAN LABA KOTOR, AKTIVITAS OPERASIONAL, AKTIVITAS INVESTASI, DAN AKTIVITAS PENDANAAN ARUS KAS TERHADAP RETURN SAHAM
Authors: Wardana Ditya , Fauziah Satya 
Published: February 2025

This research aims to analyze the effects of gross profit, and cashflow activity on stock returns by taking the population of this study, namely consumer goods companies listed on the Indonesia Stock Exchange in 2018-2019. In order to find 30 organizations that fit the criteria for the research sample, a purposive sampling method was utilized in the sampling process. SPSS is used for data analysis, including multiple regression and hypothesis testing.
Based on the results of analysis and hypothesis testing, it was found that (1) gross profit did not affect stock returns, so the first hypothesis was rejected; (2) stock returns are unaffected by cash flow from operating activities, so the second hypothesis is rejected; (3) Investing activity cash flows have an impact on stock returns, so the third hypothesis is accepted; (4) sock returns are unaffected by cash flows from financing activities, so the fourth hypothesis is rejected. An rise in investment cash flow will entice more investors to participate, which will raise demand for the company and drive up stock prices.
PROPERTIES OF SURFACE WATER; ADSORPTION KINETICS AND MECHANISM OF ARSENIC AND LEAD IONS REMOVAL USING A MATRIX TECHNIQUE
Authors: Demehin Abidemi Iyewumi , Awotunde John Olugbemiga , Oke Isaiah I. 
Published: February 2025

In this article, the effectiveness of adsorption techniques in removing arsenic(As) and lead(Pb) ions from the typical heavy metals contaminated surface (Tac) of the Aponmu River at different pH values (7.2, 6.4, 3.2 and 11.5) was determined using powdered eggshell. The initial dosage of selected water characteristics (pH, dissolved Oxygen, chloride, suspended solids, turbidity, As, dissolved oxygen (DO), Pb, and chemical oxygen demand (COD)) of the raw water was determined. The findings established that the average dosages of the selected pollutants were 6.48, 88.73 mgl-1, 255.67 mgl-1, 97.44 mgl-1, 290.44 NTU, 0.79 mgl-1, 0.55 mgl-1, 3.71 mgl-1 and 188.36 mg-1, for pH, dissolved Oxygen, chloride, suspended solids, turbidity, As, Pb, DO, and COD, respectively. In the case of adsorption, Pe was able to remove 99.98 % and 99.99 % of As and Pb dosage, respectively. Adsorption kinetics were in the range of 0.12878 and 0.37051, 0.0782 and 0.31757 for As and Pb respectively. It was concluded that adsorption mechanisms for these selected toxic pollutants (As and Pb) were mainly ion exchange and precipitation.
Factores psicosociales del cuidador principal de personas con discapacidad motora
Authors: Pilamunga Peralta Ana Lucía , Mera Herrera Viviana del Rocio 
Published: February 2025

Introducción. La figura del cuidador principal en personas con discapacidad motora es vital, no solo por la asistencia directa proporcionada, sino también por su papel que desempeña en el bienestar general de la persona con esta condición. Objetivo. Analizar los factores psicosociales del cuidador principal de personas con discapacidad motora. Metodología. El presente trabajo investigativo se desarrollará aplicando la metodología observacional, descriptiva, no experimental, por medio de una revisión documental, los documentos científicos de alto impacto. Resultados. Se encontraron algunas similitudes en cuanto a la carga psicosocial experimentada por los cuidadores de personas con diversas condiciones de discapacidad o enfermedades crónicas. Un hallazgo consistente es el alto nivel de estrés y agotamiento emocional entre los cuidadores principales. Conclusión. Sintetizar y organizar de manera eficiente la evidencia científica existente en relación con los factores psicosociales del cuidador principal de personas con discapacidad motora, desde una visión integral. Área de estudio general: Salud Área de estudio específica: Salud Pública Tipo de estudio: Artículo original.
Reid on Volition and Exertion
Authors: Stuart Matthew 
Published: February 2025

Volition and exertion play key roles in Reid’s philosophy, but his handling of them has been disputed. Some claim that he identifies volition and exertion, others that he is inconsistent or unclear about this. Some claim that he quietly slides between using ‘exertion’ in two or three different senses. I aim to clarify Reid’s notions of volition and exertion, and to defend him against the charges of inconsistency and ambiguity. I argue that from 1780 to 1792 he consistently distinguishes volition and exertion. Throughout this period, he takes a volition to be a decision or intention to do something, and an exertion to be an attempt to do something. I maintain that ‘exertion’ is no more ambiguous for Reid than it is for any ordinary speaker of English.
Ups and downs of expatriate health sciences students: towards an understanding of experiences, needs, and suggested recommendations in an Emirati university
Authors: Ahmed Fatma Refaat , Awad Ramadan Ezat , Nassir Huda M. , Mostafa Shahd Tarek , Oujan Batool Ghiath , Mohamed Basem Ali , Abumukheimar Loai A. H. , Abraham Mini Sara , Al-Yateem Nabeel , Al-tamimi Muna , Mottershead Richard , Dias Jacqueline Maria , Subu Muhammad Arsyad , AbuRuz Mohannad Eid 
Published: February 2025

AimTo describe the lived experiences of expatriate students enrolled in an academic institution in the UAE and explore suggested improvement strategies to address their challenges.BackgroundExploring the experiences of expatriate students is crucial for three main reasons. First, expatriate students play a key role in the UAE’s sustainable socio-economic development and diversification. Second, cultural differences among expatriate students raise personal, social, and academic challenges, including pedagogical issues concerning teaching and learning styles and effectiveness. Third, given the global importance of internationalization, expatriates’ experiences should be considered an issue of customer satisfaction.MethodA descriptive, qualitative, narrative study using indirect Colaizzi content analysis of 23 expatriate students’ reflections on their experiences and suggested recommendations.ResultsThe consistent themes cited by participants concerning their experiences centered on dormitory-study life balance, socialization and support networks, and navigating financial challenges. They identified areas for improvement in terms of professional, social, peer, and self-support.ConclusionDeveloping an effective support system is essential to ensure a smooth expatriate student experience. The study findings propose suggestions and recommendations that may help in future planning, including maximizing professional support, providing peer tutoring, boosting academic advising and consultation, encouraging student socialization, and guiding self-development as necessary.
Genetic characterization of a rare case of pheochromocytoma in a pulmonary transplant patient
Authors: Parisien-La Salle Stéfanie , Perreault Florence , Corbeil Gilles , Morisset Julie , Poirier Charles , Beauregard Catherine , Räkel Agnès , Labrecque Marjorie , Tétreault Martine , Cohade Christian , Ferraro Pasquale , Bourdeau Isabelle 
Published: February 2025

BackgroundPheochromocytomas (PCCs) and paragangliomas (PGLs) (PPGLs) are rare tumours arising from the chromaffin cells. There is evidence suggesting a link between hypoxemia and PPGLs. Chronic hypoxia can lead to gain of function somatic variants in the EPAS1 gene that encodes for hypoxia-inducible factor 2-alpha (HIF-2α), involved in PPGL tumorigenesis.ObjectiveTo describe a rare case of PCC in a pulmonary transplant patient and characterize the tumour’s genetic background.Clinical CaseA 47 year-old man underwent a lung transplant for chronic obstructive pulmonary disease associated with alpha-1 antitrypsin deficiency. He required home oxygen therapy for 3 years prior to transplant. Nineteen years after transplant, a CT-scan revealed a 5.8 cm x 3.9 cm heterogeneous right adrenal mass (HU of 7). Initial assessments indicated elevated 24-hour urinary catecholamines. Consequently, the patient underwent laparoscopic right adrenalectomy, confirming the PCC diagnosis.Genetic studies1) Germline PPGL multigene panel: After consent, the patient underwent a panel of 14 susceptibility genes for PPGLs that revealed no pathogenic variants. 2) Somatic genetic analysis for EPAS1 gene found no variants. However, tumoral RNA sequencing unveiled activation of the HIF pathway.ConclusionWe describe a rare case of PCC in a pulmonary transplant recipient, with genetic analyses showing no germline pathogenic variants and no somatic variants in the EPAS1 gene. RNA sequencing highlighted HIF pathway activation and angiogenic implications. Further research is necessary to elucidate the genetic and molecular mechanisms underlying PCCs in this specific case and determine its link with hypoxemia in the context of pulmonary disease.
Association between magnesium depletion score and prevalence of hyperuricemia in American adults: a study based on NHANES 2007-2018
Authors: Xiao Yongchun , Mou Yong , Wu Ping , Wang Ke , Chen Tianjun , Chen Zhiwan , Lin Hongsheng , Yang Hua , Ji Zhisheng 
Published: February 2025

BackgroundThe Magnesium Depletion Score (MDS) is a novel indicator that integrates multiple factors to assess systemic magnesium depletion. However, its association with hyperuricemia (HUA) prevalence remains unclear. This study aims to investigate the relationship between MDS and the prevalence of HUA.MethodsA cross-sectional analysis was conducted using data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES). The MDS was derived by integrating multiple risk factors associated with magnesium depletion: the use of diuretics and proton pump inhibitors (PPI), estimated glomerular filtration rate (eGFR), and alcohol consumption exceeding recommended thresholds. Univariable and multivariable logistic regression models assessed the association between MDS and HUA. Subgroup and sensitivity analyses, including the exclusion of gout patients, further evaluated this association.ResultsAmong 18,761 participants, higher MDS were associated with an increased prevalence of HUA. Multivariable logistic regression confirmed a significant positive association between MDS and HUA (OR = 1.73, 95% CI = 1.62-1.84). Restricted cubic splines (RCS) further characterized the non-linear relationship between MDS and HUA prevalence. Subgroup analysis indicated a positive association between MDS and HUA, with significant interactions observed for sex and body mass index. Sensitivity and additional analyses reinforced the robustness of these findings.ConclusionAmong U.S. adults, higher MDS were significantly associated with an increased prevalence of HUA, suggesting that interventions targeting magnesium deficiency could be beneficial in reducing HUA prevalence within this population. However, prospective studies are needed to further confirm these findings.
The relationship between anxiety and cardiometabolic risk factors in adolescents with obesity: propensity scores
Authors: Villasis-Keever Miguel Angel , Zurita-Cruz Jessie Nallely , Pichardo-Estrada Areli Zulema , Mazón-Aguirre Wendy Alejandra 
Published: February 2025

BackgroundIt has been described that there is a relationship between metabolic health and anxiety.ObjectiveTo determine the relationship between anxiety and metabolic syndrome, as well as cardiometabolic risk factors, in adolescents with obesity.MethodsWe conducted a comparative cross-sectional study of adolescents with obesity between January 2019 and December 2022. In each patient, we recorded somatometric measurements, lipid profiles, and serum insulin levels. Anxiety was measured using the Spence Children’s Anxiety Scale. Participants were divided into those with and without anxiety. Patients with anxiety were matched to patients without anxiety using propensity scores based on z-score body mass index (zBMI). Mann–Whitney U tests and χ2 tests were used.ResultsOf the 564 adolescents, 32.6% (n = 184) suffered from anxiety. In the overall study population, no differences in biochemical and cardiometabolic parameters were observed between the adolescents with and without anxiety prior to adjusting the groups based on zBMI. After matching using their zBMI, we found that the adolescents with anxiety had higher serum uric acid levels (5.9 mg/dl vs. 5.4 mg/dl, p = 0.041), an increased incidence of metabolic syndrome (39.1% vs. 15.9%, p = 0.002), hyperglycemia (21.7% vs. 8.6%, p = 0.020), and lower HDLc (67.3% vs. 34.7%, p &lt; 0.001), than those without anxiety. Girls with anxiety had a higher proportion of cardiometabolic risk factors compared to those without anxiety.ConclusionsAdolescents with obesity and anxiety had higher cardiometabolic risk factors than those without anxiety.
An anoikis-related signature predicts prognosis and immunotherapy response in gastrointestinal cancers
Authors: Liu Ruyi , Liu Yuchen , Huang Weicheng , Chen Pengxiang , Cheng Yufeng 
Published: February 2025

BackgroundGastrointestinal (GI) cancers have high incidence rates and mortality rates. Anoikis is a special type of cell apoptosis, and anoikis resistance has been reported to be associated with tumor malignancy. We aimed to explore the roles of anoikis-related genes (ARGs) in the GI cancer prognosis.MethodsWe extracted RNA sequencing and clinical data from The Cancer Genome Atlas and Gene Expression Omnibu databases for patients with esophageal cancer, gastric cancer, colon cancer and rectal cancer and identified ARGs from GeneCards and Harmonizome. Anoikis-related patterns were identified via unsupervised clustering analysis. We constructed a prognostic signature (Anoscore) based on prognostic ARGs through univariate, LASSO, and multivariate Cox regression analyses. The model was validated and evaluated using Kaplan–Meier analysis, receiver operating characteristic curves, univariate Cox regression analysis, multivariate Cox regression analysis, column charts, and calibration curves. We also performed a single-cell sequencing analysis of candidate genes via TISCH2. A correlation analysis between the Anoscore, the tumor microenvironment and drug sensitivity was conducted in GI cancers. The expression and function of some candidate genes were validated in vitro.ResultsIn terms of prognostic ARGs, two anoikis-related patterns, ARG clusters A and B, were identified. ARG cluster B had a worse prognosis than did ARG cluster A. Subsequently, the Anoscore was developed as an independent prognostic factor. It demonstrated the robust predictive capability for the prognosis of patients with GI cancers. Notably, patients with high Anoscores exhibited poor outcomes. In addition, we established a nomogram (Ano-nomogram) based on the Anoscore and clinicopathological factors of patients to predict the 3-year and 5-year survival probabilities. Moreover, patients with high Anoscores had higher levels of immune cell infiltration and higher immune checkpoint expression. The drug sensitivity analysis revealed that patients with high or low Anoscores were sensitive to different chemotherapies and targeted drugs. S100A11 and TLR3, representative candidate genes, exhibited different expression patterns and biological functions.ConclusionThis study highlighted the significant potential of the Anoscore in predicting prognosis and guiding the selection of personalized therapeutic regimens for patients with GI cancers.
The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells
Authors: Armento Angela , Sonntag Inga , Almansa-Garcia Ana-Cristina , Sen Merve , Bolz Sylvia , Arango-Gonzalez Blanca , Kilger Ellen , Sharma Ruchi , Bharti Kapil , Fernandez-Godino Rosario , de la Cerda Berta , Clark Simon J. , Ueffing Marius 
Published: February 2025

IntroductionAge-related macular degeneration (AMD), a degenerative disease of the macula, is caused by an interplay of diverse risk factors (genetic predisposition, age and lifestyle habits). One of the main genetic risks includes the Y402H polymorphism in complement Factor H (FH), an inhibitor of complement system activation. There has been, and continues to be, much discussion around the functional consequences of this Y402H polymorphism, whether the soluble FH protein confers its risk association, or if the cells expressing the protein themselves are affected by the genetic alteration. In our study, we examined the cell characteristics of the retinal pigment epithelium (RPE) cells, which play a major role in retinal homeostasis and stability and which are synonymously linked to AMD.MethodsHere, we employ RPE cells derived from induced pluripotent stem cells (iPSC) generated from donors, carrying either homozygous 402Y (low risk) or 402H (high risk) variants of the CFH gene. RPE cells were treated with Hydroquinone (HQ), a component of cigarette smoke, to induce oxidative damage. ResultsIntriguingly, RPE cells carrying high genetic risk proved more vulnerable to oxidative insult when exposed to HQ, as demonstrated by increased cytotoxicity and caspase activation, compared to the low-risk RPE cells. The exposure of RPE cells to RPE conditioned medium, normal human serum (NHS) and inactivated NHS (iNHS) had minimal impact on cell cytotoxicity and caspase activation, nor did the presence of purified soluble FH rescue the observed effects. Considering the known connection of oxidative stress to proteotoxic stress and degrading processes, we investigated the unfolded protein response (UPR) and autophagy. When exposed to HQ, RPE cells showed an increase in autophagy markers; however, iPSC-RPE cells carrying high genetic risk showed an overall reduced autophagic flux. DiscussionOur findings suggest that the degree of cellular susceptibility to oxidative stress is not conferred by soluble FH protein and other complement sources, but intercellularly because of the corresponding genetic risk predisposition. Our data support the hypothesis that RPE cells carrying high genetic risk are less resilient to oxidative stress.
Endocrine and metabolic comorbidities in juvenile-onset systemic lupus erythematosus
Authors: Park Su Jin , Ahn Moon Bae , Jeong Dae Chul 
Published: February 2025

Background and aimsJuvenile-onset systemic lupus erythematosus (JSLE) is a chronic autoimmune disease affecting individuals under 18, causing multi-system impairment. Patients with JSLE exhibit more severe disease when compared to patients with adult-onset SLE. This study aimed to evaluate the prevalence of endocrine and metabolic comorbidities in patients with JSLE, and analyze the factors associated with each comorbidity.MethodsAnthropometric, clinical, laboratory data, and the details of glucocorticoids and disease-modifying anti-rheumatic drugs use were collected.ResultsA total of 57 patients with JSLE (48 girls and 9 boys) were included in this study. Endocrine and metabolic comorbidities were observed in 64.9% of the patients. The most prevalent comorbidities were dyslipidemia (40.4%), being overweight or obese (26.3%), subclinical hypothyroidism (24.6%), autoimmune thyroid disease (AITD) (21.1%), and low bone mass (20.9%). The risk of dyslipidemia and AITD increased in patients who were overweight or obese. The risk of being overweight or obese was associated with skin involvement at diagnosis and rheumatoid factor positivity. Younger age at diagnosis and longer duration of glucocorticoid exposure increased the risk of low bone mass. The overall prevalence of endocrine and metabolic comorbidities was associated with short stature at diagnosis, being overweight or obese at follow-up, skin involvement at diagnosis, and rheumatoid factor positivity.ConclusionPatients with JSLE have higher burdens of endocrine and metabolic comorbidities and should be routinely monitored. Prevention of obesity may be helpful in lowering the risk of comorbidities.