bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Impact of Prostate-Specific Antigen at 6 Months After Radiotherapy in Localized Prostate Cancer: An Individual Patient Data Analysis of Randomized Trials
Authors: Kwak Lucia , Ravi Praful , Armstrong John G. , Beckendorf Veronique , Chin Joseph L. , D'Amico Anthony V. , Dearnaley David P. , Di Stasi Savino M. , Gillessen Silke , Lukka Himanshu , Mottet Nicolas , Pommier Pascal , Seiferheld Wendy , Sydes Matthew R. , Tombal Bertrand , Zapatero Almudena , Regan Meredith M. , Xie Wanling , Sweeney Christopher J. 
Published: March 2024

PURPOSE We sought to evaluate the prognostic impact of prostate-specific antigen (PSA) at 6 months after completion of radiotherapy (RT) in patients treated with RT alone, RT plus short-term (st; 3-6 months), and RT plus long-term (lt; 24-36 months) androgen-deprivation therapy (ADT). PATIENTS AND METHODS Individual patient data were obtained from 16 randomized trials evaluating RT ± ADT for localized prostate cancer (PCa) between 1987 and 2011. The lowest PSA recorded within 6 months after RT completion was identified and categorized as < or ≥0.1 ng/mL. The primary outcomes were metastasis-free survival (MFS), PCa-specific mortality (PCSM), and overall survival (OS), from 12 months after random assignment. RESULTS Ninety-eight percent (n = 2,339/2,376) of patients allocated to RT alone, 84% (n = 4,756/5,658) allocated to RT + stADT, and 77% (n = 1,258/1,626) allocated to RT + ltADT had PSA ≥0.1 ng/mL within 6 months after completing RT. PSA ≥0.1 ng/mL was associated with lower MFS and OS and higher PCSM among patients allocated to RT ± ADT (RT – MFS: hazard ratio [HR], 2.24 [95% CI, 1.21 to 4.16]; PCSM: subdistribution hazard ratio [sHR], 1.82 [0.51 to 6.49]; OS: HR, 1.72 [0.97 to 3.05]; RT + stADT – MFS: HR, 1.27 [1.12 to 1.44]; PCSM: sHR, 2.10 [1.52 to 2.92]; OS: HR, 1.26 [1.11 to 1.44]; RT + ltADT – MFS: HR, 1.58 [1.27 to 1.96]; PCSM: sHR, 1.97 [1.11 to 3.49]; OS: HR, 1.59 [1.27 to 1.99]). Five-year MFS rates among patients allocated to RT, RT + stADT, and RT + ltADT were 91% versus 79%, 83% versus 76%, and 87% versus 74%, respectively, based on PSA < or ≥0.1 ng/mL. CONCLUSION PSA ≥0.1 ng/mL within 6 months after RT completion was prognostic for lt outcomes in patients treated with RT ± ADT for localized PCa. This can be used to counsel patients treated with RT ± ADT and in guiding clinical trial design evaluating novel systemic therapies with RT + ADT as well as (de)intensification strategies.
European Stop Tyrosine Kinase Inhibitor Trial (EURO-SKI) in Chronic Myeloid Leukemia: Final Analysis and Novel Prognostic Factors for Treatment-Free Remission
Authors: Mahon Francois-Xavier , Pfirrmann Markus , Dulucq Stéphanie , Hochhaus Andreas , Panayiotidis Panayiotis , Almeida Antonio , Mayer Jiri , Hjorth-Hansen Henrik , Janssen Jeroen J.W.M. , Mustjoki Satu , Martinez-Lopez Joaquin , Vestergaard Hanne , Ehrencrona Hans , Machová Poláková Katerina , Olsson-Strömberg Ulla , Ossenkoppele Gert , Berger Marc G. , Etienne Gabriel , Dengler Jolanta , Brümmendorf Tim H. , Burchert Andreas , Réa Delphine , Rousselot Philippe , Nicolini Franck E. , Hofmann Wolf-Karsten , Richter Johan , Saussele Susanne ,   on behalf of the EURO-SKI Investigators, Mayer Jiri , Voglová Jaroslava , Faber Edgar , Klamova Hana , Vestergaard Hanne , Koskenvesa Perttu , Mahon Francois-Xavier , Etienne Gabriel , Berger Marc G. , Rousselot Philippe , Nicolini Franck E. , Charbonnier Aude , Legros Laurence , Réa Delphine , Guilhot François , Escoffre-Barbe Martine , Huguet Françoise , Gyan Emmanuel , Brümmendorf Tim Henrik , Waller Cornelius , Dengler Jolanta , Hochhaus Andreas , Saußele Susanne , Burchert Andreas , Kunzmann Volker , Pagoni Maria N. , Panayiotidis Panayiotis , Janssen Jeroen J.W.M. , Ossenkoppele Gert , Westerweel Peter E. , de Greef Georgine E. , Gruber Franz , Hjorth-Hansen Henrik , Almeida Antonio , Martinez-Lopez Joaquin , Lotfi Kourosh , Richter Johan , Stenke Leif , Olsson-Strömberg Ulla , Söderlund Stina 
Published: March 2024

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. The European Stop Kinase Inhibitors (EURO-SKI) study is the largest clinical trial for investigating the cessation of tyrosine kinase inhibitors (TKIs) in patients with chronic myeloid leukemia in stable deep molecular remission (DMR). Among 728 patients, 434 patients (61%; 95% CI, 57 to 64) remained in major molecular response (MMR) at 6 months and 309 patients of 678 (46%; 95% CI, 42 to 49) at 36 months. Duration of TKI treatment and DMR before TKI stop were confirmed as significant factors for the prediction of MMR loss at 6 months. In addition, the type of BCR::ABL1 transcript was identified as a prognostic factor. For late MMR losses after 6 months, TKI treatment duration, percentage of blasts in peripheral blood, and platelet count at diagnosis were significant factors in multivariate analysis. For the entire study period of 36 months, multiple logistic regression models confirmed duration of treatment, blasts, and transcript type as independent factors for MMR maintenance. In addition to the duration of treatment, transcript type as well as blasts in peripheral blood at diagnosis should be considered as important factors to predict treatment-free remission.
Lower Prevalence of Diabetic Ketoacidosis at Diagnosis in Research Participants Monitored for Hyperglycemia
Authors: Sooy Morgan , Pyle Laura , Alonso Guy Todd , Broncucia Hali C , Rewers Arleta , Gottlieb Peter A , Simmons Kimber M , Rewers Marian J , Steck Andrea K 
Published: March 2024

Abstract

Context
In Colorado children, the prevalence of diabetic ketoacidosis (DKA) at diagnosis of type 1 diabetes has been increasing over time.

Objective
To evaluate the prevalence of and factors involved in DKA at type 1 diabetes diagnosis among participants followed in monitoring research studies before diagnosis compared to patients from the community.

Methods
We studied patients &lt; 18 years diagnosed with type 1 diabetes between 2005 and 2021 at the Barbara Davis Center for Diabetes and compared the prevalence of and factors associated with DKA at diagnosis among participants in preclinical monitoring studies vs those diagnosed in the community.

Results
Of 5049 subjects, 164 were active study participants, 42 inactive study participants, and 4843 were community patients. Active study participants, compared to community patients, had lower HbA1c (7.3% vs 11.9%; P &lt; .001) and less frequently experienced DKA (4.9% vs 48.5%; P &lt; .001), including severe DKA (1.2% vs 16.2%; P &lt; .001). Inactive study participants had intermediate levels for both prevalence and severity of DKA. DKA prevalence increased in community patients, from 44.0% to 55%, with less evidence for a temporal trend in study participants. DKA prevalence was highest in children &lt; 2 years (13% in active study participants vs 83% in community patients). In community patients, younger age (P = .0038), public insurance (P &lt; .0001), rural residence (P &lt; .0076), higher HbA1c (P &lt; .0001), and ethnicity minority status (P &lt; .0001) were associated with DKA at diagnosis.

Conclusion
While DKA prevalence increases in community patients over time, it stayed &lt; 5% in active research participants, who have a 10 times lower prevalence of DKA at diagnosis, including among minorities.
Research Note: New Evidence on the Motherhood Wage Penalty
Authors: Yu Wei-hsin , Kuo Janet Chen-Lan 
Published: March 2024

Abstract
U.S. women's age at first birth has increased substantially. Yet, little research has considered how this changing behavior may have affected the motherhood pay penalty, or the wage decrease with a child's arrival, experienced by the current generation. Using Rounds 1–19 of the National Longitudinal Survey of Youth 1997 (NLSY97), in this research note we examine shifts in hourly pay with childbirth for a cohort of women who became mothers mostly in the 2000s and 2010s. Results from fixed-effects models indicate that the motherhood pay penalty for NLSY97 women who had their first child before their late 20s is generally similar to that of previous cohorts. Those who became mothers near or after age 30, however, encounter a parenthood premium, as men do. The growing proportion of women delaying motherhood, coupled with the rising heterogeneity in motherhood wage outcomes by childbearing timing, contributes to a comparatively small motherhood penalty for this recent cohort. The pay advantage of “late mothers” cannot be explained by factors such as their labor market locations, number of children, stage of childrearing, marital status, or ethnoracial composition. Instead, the hourly gain stems from such mothers’ tendency to reduce working hours more than other mothers without experiencing a commensurate decrease in total pay. Unlike the fatherhood premium, the premium for late mothers does not lead to a real boost in income.
Higher Postoperative Mortality and Inferior Survival After Right-Sided Liver Resection for Perihilar Cholangiocarcinoma: Left-Sided Resection is Preferred When Possible
Authors: Olthof Pim B. , Erdmann Joris I. , Alikhanov Ruslan , Charco Ramón , Guglielmi Alfredo , Hagendoorn Jeroen , Hakeem Abdul , Hoogwater Frederik J. H. , Jarnagin William R. , Kazemier Geert , Lang Hauke , Maithel Shishir K. , Malago Massimo , Malik Hassan Z. , Nadalin Silvio , Neumann Ulf , Olde Damink Steven W. M. , Pratschke Johann , Ratti Francesca , Ravaioli Matteo , Roberts Keith J. , Schadde Erik , Schnitzbauer Andreas A. , Sparrelid Ernesto , Topal Baki , Troisi Roberto I. , Groot Koerkamp Bas ,   Perihilar Cholangiocarcinoma Collaboration Group, Aldrighetti L. , Bartsch F. , Bechstein W. O. , Bednarsch J. , de BenzingBoer C. M. A. , Bouwense S. A. , Capobianco I. , Cescon M. , D’Angelica M. I. , Dewulf M. , de Reuver P. , de Savornin Lohman E. , Efanov M. , Franken L. C. , Geers J. , Giglio M. C. , Gilg S. , Gomez-Gavara C. , van Gulik T. M. , Heil J. , IJzermans J. N. M. , Jansson H. , Kingham T. P. , Lodge P. , Margies R. , Marino R. , Molenaar Q. I. , Nguyen T. A. , Nooijen L. E. , Nota C. L. M. , Poletto E. , Porte R. J. , Prasad R. , Quinn L. M. , Rolinger J. , Ruzzenente A. , Schmelzle M. , Serenari M. , Sultana A. , van Laarhoven S. , Zonderhuis B. M. 
Published: March 2024

Abstract
Background
A right- or left-sided liver resection can be considered in about half of patients with perihilar cholangiocarcinoma (pCCA), depending on tumor location and vascular involvement. This study compared postoperative mortality and long-term survival of right- versus left-sided liver resections for pCCA.

Methods
Patients who underwent major liver resection for pCCA at 25 Western centers were stratified according to the type of hepatectomy—left, extended left, right, and extended right. The primary outcomes were 90-day mortality and overall survival (OS).

Results
Between 2000 and 2022, 1701 patients underwent major liver resection for pCCA. The 90-day mortality was 9% after left-sided and 18% after right-sided liver resection (p < 0.001). The 90-day mortality rates were 8% (44/540) after left, 11% (29/276) after extended left, 17% (51/309) after right, and 19% (108/576) after extended right hepatectomy (p < 0.001). Median OS was 30 months (95% confidence interval [CI] 27–34) after left and 23 months (95% CI 20–25) after right liver resection (p < 0.001), and 33 months (95% CI 28–38), 27 months (95% CI 23–32), 25 months (95% CI 21–30), and 21 months (95% CI 18–24) after left, extended left, right, and extended right hepatectomy, respectively (p < 0.001). A left-sided resection was an independent favorable prognostic factor for both 90-day mortality and OS compared with right-sided resection, with similar results after excluding 90-day fatalities.

Conclusions
A left or extended left hepatectomy is associated with a lower 90-day mortality and superior OS compared with an (extended) right hepatectomy for pCCA. When both a left and right liver resection are feasible, a left-sided liver resection is preferred.
The Power of Knowing a Woman Is in Charge: Lessons from a Randomized Experiment
Authors: Dobrescu Loretti , Motta Alberto , Shanker Akshay 
Published: March 2024

As part of a term-long anonymous assessment, thousands of undergraduate university students were divided into groups, each led by a randomly selected peer. The leader’s gender had no effect on the assessment’s outcomes, but female students led by a female peer achieved 0.26 standard deviations (SD) higher course grades when the gender of the leader was revealed. They also outperformed by 0.22 SD their counterparts in groups in which the leader’s gender was revealed to be male. The mechanism involved attempting more difficult practice questions. Our structural estimates suggest this operated via a stereotype threat reversal that reduced anxiety. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.00325 .
Designing Service Menus for Bipartite Queueing Systems
Authors: Caldentey René , Hillas Lisa Aoki , Gupta Varun 
Published: March 2024

Designing Fair and Incentive-Compatible Matching Systems Many service systems face the challenge of dynamically matching customers who have heterogeneous preferences with an available pool of service providers in a fair and equitable manner. The first come, first served (FCFS) service discipline offers a straightforward and fair approach to allocate arriving customers to available servers and manage congestion. However, FCFS may limit the ability of service providers to reach an efficient allocation based on the individual preferences of customers and the characteristics of servers. In “Designing Service Menus for Bipartite Queuing Systems,” Caldentey, Hillas, and Gupta develop a queueing framework to address this dynamic matching problem. Their proposed methodology enables service providers to offer a menu of different service classes, each served by a distinct pool of servers. By thoughtfully designing this menu, a service provider can encourage self-interested customers to select service classes in a way that optimizes the trade-off between quality of matching and waiting time delays.
Finding Creativity in Predictability: Seizing Kairos in Chronos Through Temporal Work in Complex Innovation Processes
Authors: Otto Birke D. , Schuessler Elke S. , Sydow Jörg , Vogelgsang Lukas 
Published: March 2024

Managing temporal complexity is a fundamental challenge in complex innovation processes, yet the temporal work whereby actors seize opportune moments (kairos) in an environment dominated by clock-time structures (chronos) remains elusive. Temporal tensions can partly be resolved through entrainment, that is, by aligning activities with dominant temporal structures. However, although entrainment ensures the exploitation of a predefined path, it is unable to harness unexpected developments as opportunities for exploration. Thus, navigating the competing temporal demands of chronos and kairos requires not just ambidextrous but also ambitemporal organizing. Collecting and analyzing in-depth interview and observational data from pharmaceutical drug discovery and development, we find that actors sometimes resolve temporal tensions through entrainment to ensure coordination and predictability. In other instances, however, actors abductively transform temporal tensions into novel interpretations and new courses of action. As such, temporal tensions become more than a bothersome deviation from the planned schedule, but an opportunity for creative agency. This understanding of kairos—as a process unfolding through temporal work—relies not only on detraining from chronos (i.e., momentarily detaching from the dominant temporal structure to question underlying assumptions), but also on its reframing and reconfiguration. We contribute to the literature on complex innovation and temporality by theorizing a transformative perspective on ambitemporal organizing, which relies less on paradoxical notions and instead emphasizes how kairos is enacted and seized within and from chronos. Funding: This work was supported by German Research Foundation (DFG) funding for the Research Unit “Organized Creativity” [Grant FOR 2161] as well as by the Austrian Science Fund (FWF) [10.55776/I4884].
The relationship between caregiver contribution to self-care and patient quality of life in heart failure: A longitudinal mediation analysis
Authors: Caggianelli Gabriele , Alivernini Fabio , Chirico Andrea , Iovino Paolo , Lucidi Fabio , Uchmanowicz Izabella , Rasero Laura , Alvaro Rosaria , Vellone Ercole 
Published: March 2024

Background
Patients with heart failure may experience poor quality of life due to a variety of physical and psychological symptoms. Quality of life can improve if patients adhere to consistent self-care behaviors. Patient outcomes (i.e., quality of life) are thought to improve as a result of caregiver contribution to self-care. However, uncertainty exists on whether these outcomes improve as a direct result of caregiver contribution to self-care or whether this improvement occurs indirectly through the improvement of patient heart failure self-care behaviors.

Aims
To investigate the influence of caregiver contribution to self-care on quality of life of heart failure people and explore whether patient self-care behaviors mediate such a relationship.

Methods
This is a secondary analysis of the MOTIVATE-HF randomized controlled trial (Clinicaltrials.gov registration number: NCT02894502). Data were collected at baseline and 3 months. An autoregressive longitudinal path analysis model was conducted to test our hypotheses.

Results
We enrolled a sample of 510 caregivers [mean age = 54 (±15.44), 24% males)] and 510 patients [mean age = 72.4 (±12.28), 58% males)]. Patient self-care had a significant and direct effect on quality of life at three months (β = 0.20, p < .01). Caregiver contribution to self-care showed a significant direct effect on patient self-care (β = 0.32, p < .01), and an indirect effect on patient quality of life through the mediation of patient self-care (β = 0.07, p < .001).

Conclusion
Patient quality of life is influenced by self-care both directly and indirectly, through the mediation of caregiver contribution to self-care. These findings improve our understanding on how caregiver contribution to self-care improves patient outcomes.
Influence of Moringa Leaf Meal As a Feed Additive on Antibody and Bursa Histomorphometry of Hybrid Ducklings
Authors: Febriana Wisca , Suprihatin Teguh , Kasiyati Kasiyati 
Published: March 2024

Moringa leaf meal contains various phytonutrients that benefit animal and human health.Â This research is designed to evaluate Moringa leaf meal as a feed additive on antibody response and histomorphometry of the bursa Fabricius of hybrid duck administrated by ND vaccine.Â The experimental design used is a Completely Randomized Design (CRD) using thirty-two male hybrid ducks of three days old.Â They were divided into four treatment groups and eight replicates of each.Â The first group was standard commercial fed without adding ofÂ Moringa leaf meal (0%), while the second until the fourth group was a standard commercial fed with 2.5%, 5%, and 7.5% adding of Moringa leaf meal.Â All groups were vaccinated by ND1 and ND2, respectively, at the age of seventh and fourteenth days.Â The results showed that Moringa leaf meal as a feed additive had no significant effect on antibody titer, leukocyte count, lymphocytes (L), heterophils (H), H:L ratio, bursa weight, cortex, and medulla thickness of bursa.Â The concentration of serum MDA, the diameter of plica, and follicles bursa were significantly influenced (P0.05) by adding Moringa leaf meal.Â In conclusion, the Moringa leaf meal additive could stimulate the proliferation of bursa follicles and have no adverse effect on the immune response of hybrid ducks post-ND vaccine.
MİMARİ TASARIMIN ERKEN TASARIM EVRESİNDE ESKİZİN YARATICI DÜŞÜNMEYE ETKİSİ
Authors: TAPKI Sinem 
Published: March 2024

Mimari tasarım sürecinin erken tasarım evresinde tasarımcılar, fikirlerini somut olarak aktarabilmek için görsel ifade tekniklerinden eskizi kullanmaktadırlar. Tasarım dünyasında eskizlerin, tasarım bilgisinin oluşmasında ve tasarım düşüncesinin geliştirilmesinde bir aktarım aracından daha fazla rolü bulunmaktadır. Eskizler sahip oldukları özgür, yaratıcı ve esnek yapılarından dolayı görsel düşünmeye veriler sağlamaktadır. Görsel düşünme, bilgi ve zihindeki düşüncenin eskiz, diyagram, şema vb. yöntemlerle görselleştirmenin öğrenilmesidir. Tasarım- tasarımcı- eskiz arasında sürekli döngüsel ve sınırları belirsiz bir ilişki bulunmaktadır.
Mimari tasarım sürecinde yaratıcılık, hayal gücü, görsel düşünme ve eskizin önemli yeri olduğu bilinmektedir. Bu tasarım sürecinin sonunda, yaratıcı ve özgün ürünlerin ortaya çıkmasında görsel düşünme ile eskiz baskın rol oynamaktadır. Eskiz; tasarımcının düşünme, düşünceyi aktarma ve bilgi türetme eylemlerini zihinde kurguladığından öteye taşır. Eskiz çalışmaları, beyindeki soyut düşünceyi somutlaştırarak düşünceyi geliştirecek yaratıcı katkılar sağlamaktadır. Zihindeki düşüncelerin somutlaşması ile yeni bilgiler oluşur ve bu yeni bilgiler tekrar zihinde yorumlanarak somutlaştırılır. Böylece yeni bilgiler gelişir ve başka bilgilerin oluşmasını sağlar. Çalışma; bu sistematik süreç içerisinde eskizi, eskizin rolünü, işleyişini araştırmaktadır.
Mimari tasarım sürecinde, hayal gücü, yaratıcı düşünce ve yaratıcı düşünceyi geliştirmenin eskiz ile arasındaki ilişkinin araştırıldığı bu çalışmanın amacı; tasarım sürecinin erken tasarım evresinde eskiz sürecinin analiz edilmesidir. Tasarım sürecinde problem tanımlanıp çözülürken, proje geliştirilirken yararlanılan araçlardan biri olan eskiz çalışmaları, tasarımcıların bilişsel davranışlarını da etkileyebileceği hipotezi çalışmada öne sürülmüştür. Erken tasarım evresinde eskiz uygulamalarının süreci nasıl etkilediği, tasarımcıların bilişsel durumlarındaki etkilerin neler olduğu sorularına cevaplar aranmaktadır. Bu amaçla araştırmada bir deney gerçekleştirilmiştir. Yüz yüze ortamda iki aşamalı uygulama oluşturulmuştur. Süreçte üç adet Mimarlık Bölümü 2. Sınıf öğrencisi ile çalışılmıştır. Katılımcılardan, sınırlı süre içerisinde verilen tasarım problemine ait geleneksel ortamda eskiz yapmaları istenmiştir. Eskizlerin analizinde protokol analiz yöntemi kullanılmıştır. Eskizler içerik, biçim, sorgulama-çözümleme ilişkilerine göre değerlendirilmiştir. Yapılan analizler ve değerlendirmeler sonucunda eskizlerin tasarımcıların bilişsel durumlarını nasıl etkilediği incelenmiştir.