bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationships between cardiopulmonary function and dangerous cardiovascular factors in Chinese adults: A cross-sectional study
Authors: Liu Yun-qing , Zhi-jian Wu , Bao-hu Li , Kun Tang , Jia-han He , Xiao-yuan Ma , Li-qiang Su , Xiao-ming Yu , Fang-hui Li 
Published: March 2024

Abstract
Background
Cardiovascular disease (CVD) is a risk factor for mortality. Cardiopulmonary function (CRF) is a modifiable CVD risk factor, and low CRF levels are associated with an elevated CVD risk. However, few comprehensive explorations of the relationship between CRF and cardiometabolic health in CVD exist. Therefore, this study investigated the relationships between CVD risk factors and CRF.
Methods
In this cross-sectional study, CRF was measured using the peak oxygen uptake (i.e., peak VO2) and a cardiopulmonary exercise test. The participants were also assessed for body composition, blood glucose-related markers, blood lipid-related markers, blood pressure, and cardiovascular markers. Participants’ self-reported data on cigarette/snuff use and alcohol consumption were collected using a questionnaire. A multiple linear regression analysis was used to explore the cross-sectional correlations between CVD risk factors and CRF, controlling for covariates.
Results
Six hundred and fifty participants were included; the average age was 42 years (interquartile range: 35–51 years old), and the average CRF was 21.5 mL/kg/min. CRF was significantly and positively associated with body mass index (β = 0.149, p < 0.001), body fat percentage (β = 0.248, p < 0.001), waist circumference (β = 0.498, p < 0.001), hip circumference (β = 0.285, p < 0.001), waist-to-hip ratio (β = 0.02, p < 0.001), and high-density lipoprotein cholesterol (β = 0.005, p < 0.05). Significant negative correlations were observed between CRF and fasting blood glucose (β = − 0.023, p < 0.05), creatinine content (β = − 0.322, p < 0.05), C-reactive protein (β = − 0.026, p < 0.05), and lipid accumulation product (β = − 0.8824, p < 0.05). CRF was not related to glycosylated hemoglobin content, blood pressure, vascular markers, total cholesterol, triglycerides, or low-density lipoprotein cholesterol.
Conclusions
CRF was associated with several CVD risk factors, suggesting that improving CRF will benefit individuals by reducing the risk of CVD. CRF can be improved via exercise interventions.
Sandstone provenance and diagenesis as tools for the definition of lithostratigraphic units
Authors: Acebrón Laura González , Campos-Soto Sonia , Benito María Isabel , Quijada Emma , Suarez-Gonzalez Pablo 
Published: March 2024

Abstract

This study analyzes the provenance and diagenesis of the Upper Jurassic-Lower Cretaceous sandstone deposits of the NW South-Iberian Basin (Teruel and Valencia provinces, SE Spain) in order to understand the controls on their field appearance (color and friability), which conditioned the definition of formal lithostratigraphic units. Specifically, analyzed sandstone belongs to the Kimmeridgian-Tithonian Villar del Arzobispo Fm, a mixed carbonate-siliciclastic unit deposited in coastal, fluvial, deltaic and aeolian sedimentary environments. This unit was redefined by Campos-Soto et al. (2019), who included, at its uppermost part, the essentially siliciclastic, very friable and whitish deposits that were traditionally assigned to the Barremian El Collado Fm, because these authors demonstrated their Kimmeridgian-Tithonian age. Provenance study has included point-counting and K-feldspar and tourmaline analyzes. Sandstones are mainly arkoses, which have similar framework composition all along the studied sedimentary record. The absence of plagioclases in all samples indicates strong chemical weathering in source areas, which is characteristic of warm and wet climatic conditions. The source areas were mostly peraluminic granites, probably from the Central Iberian Zone (Iberian Massif), located more than 200 km away to the NW of the study area, and Paleozoic quartzites, slates and schists from the Iberian Massif plus sedimentary rocks from nearby areas. The lower and middle-upper parts of the Villar del Arzobispo Fm have sedimentary carbonate rock fragments, which produced pervasive carbonate precipitation during diagenesis, generating their competent field appearance. However, the uppermost part of this formation, traditionally assigned to the El Collado Fm, has very low carbonate rock fragments and large amount of kaolinite epimatrixes, which generated its whitish and friable appearance. Thus, the color and friability of the sandstone deposits were mainly controlled by diagenetic processes and not by changes in source areas, advising the consideration of diagenetic processes when defining sandstone stratigraphic units.
Osteocalcin and Chinese visceral adiposity index are associated with the risk of ASCVD and arterial stiffness in patients with T2DM
Authors: Gong Caixia , Chen Chongyang , Zhao Yangting , Wang Yawen , Li Kai , Lv Xiaoyu , Gao Jie , Zhao Pingping , Fu Songbo , Liu Jingfang 
Published: March 2024

Abstract

This study aims to discover the association between serum osteocalcin, the Chinese visceral adiposity index (CVAI), and atherosclerotic cardiovascular disease (ASCVD) risk, and their impact on arterial stiffness in T2DM patients. We included 646 T2DM patients aged 18 and older who received the assessment of ASCVD risk using the China-PAR equation, Osteocalcin and arterial stiffness in this cross-sectional study. We found that osteocalcin and CVAI as independent risk factors for both medium-high-risk ASCVD (osteocalcin: men, OR,0.958, 95%CI 0.923, 0.99, women, OR, 0.788, 95%CI 0.645, 0.96, respectively)(CVAI: men, OR,1.010, 95%CI 1.00, 1.02, women, OR,1.084, 95%CI 1.00, 1.17, respectively) and arterial stiffness (osteocalcin: men, OR, 0.958, 95%CI 0.92, 1.00, women, OR, 0.925, 95%CI 0.86, 0.99, respectively)(CVAI: men, OR,1.011, 95%CI 1.003, 1.02, women, OR,1.0217, 95%CI 1.00, 1.03, respectively) in both men and women patients with T2DM. Combining osteocalcin levels and CVAI improved the prediction accuracy of arterial stiffness in men patients with T2DM (difference of AUC (Model 4 vs. Model 1):1.4%). All P-values were < 0.05. The results suggested that osteocalcin levels and CVAI are independent risk factors for ASCVD risk and arterial stiffness in T2DM. Combining osteocalcin and CVAI can enhance the early detection of atherosclerosis through male patients with T2DM.
Beach resilience to storm-induced erosion: a machine learning-driven approach to identify key morphometrics to recovery
Authors: Thilakarathne Salika , Suzuki Takayuki , Mäll Martin , Banno Masayuki 
Published: March 2024

Abstract
In the context of ongoing discussions about climate change, the focus on beach resilience has gained significant attention in contemporary studies. However, a comprehensive understanding of beach resilience, particularly in the short term, remains limited. This study utilizes a dataset of 104 storm events in Hasaki beach, located on the East coast of Japan, to investigate the 10-day beach recovery. The study considers four types of distinct beach profile patterns based on sandbar formations. Employing XGBoost and the SHAP explanation method, the influence of morphometric indicators on beach resilience were explored. Resilient beach profiles are anticipated to exhibit rapid recovery following erosional storm events. The results reveal that morphometrics play a crucial role in determining the short-term, 10-day, recovery of beaches, with specific morphometric features demonstrating pronounced effects based on profile patterns. The study contributes to the current knowledge of post-storm beach recovery and provides insights that could inform discussions on beach resilience.
Inclusion at Ukrainian universities: a view from the inside
Authors: Tsybuliak Natalia , Mytsyk Hanna , Suchikova Yana , Lopatina Hanna , Popova Anastasia , Hurenko Olha , Hrynkevych Olha 
Published: March 2024

Abstract

This study investigates the state of inclusivity in Ukrainian universities, focusing on the perceptions of university staff amid the country's ongoing sociopolitical transformations. By consulting 820 staff members from various professional roles, including academic, management, and support positions, this research explored inclusivity through diverse lenses, encompassing work experience, interactions with students with disabilities, and self-identification with vulnerable groups. The majority of respondents assessed a moderate to high level of inclusivity, indicating a positive overall outlook on inclusive practices within these institutions. Notably, perceptions of inclusivity vary slightly across different professional roles, with academic staff expressing a marginally lower level of perceived inclusivity than their counterparts. However, these variations are not statistically significant, suggesting a broadly uniform perception across staff categories. Furthermore, the study revealed that personal experience in working with students with disabilities does not substantially alter staff perceptions of inclusivity. Similarly, self-identification with vulnerable groups only marginally influences these perceptions. This suggests that while individual experiences and identities are factors in inclusivity perceptions, their impact is not profoundly different. This research contributes to the understanding of inclusivity in higher education, particularly within environments undergoing significant social and political changes.
Wear fault diagnosis in hydro-turbine via the incorporation of the IWSO algorithm optimized CNN-LSTM neural network
Authors: Dao Fang , Zeng Yun , Zou Yidong , Qian Jing 
Published: March 2024

Abstract

Diagnosing hydro-turbine wear fault is crucial for the safe and stable operation of hydropower units. A hydro-turbine wear fault diagnosis method based on improved WT (wavelet threshold algorithm) preprocessing combined with IWSO (improved white shark optimizer) optimized CNN-LSTM (convolutional neural network-long-short term memory) is proposed. The improved WT algorithm is utilized for denoising the preprocessing of the original signals. The CNN-LSTM hydro-turbine wear fault diagnosis model is constructed. Aiming at the problem that the WSO algorithm quickly falls into local optimum and premature convergence, tent chaotic mapping is used to initialize the population and birds flock search behavior. The cosine elite variation strategy is introduced to improve convergence speed and accuracy. Hyperparameter tuning of CNN-LSTM model based on IWSO algorithm. The experimental results show that the accuracy of the proposed method reaches 96.2%, which is 8.9% higher than that of the IWSO-CNN-LSTM model without denoising. The study also found that the diagnostic accuracy of hydro-turbine wear faults increased with increasing sediment concentration in the water. This study can supplement the existing hydro-turbine condition monitoring and fault diagnosis system. Meanwhile, diagnosing wear faults in hydro-turbines can improve power generation efficiency and quality and minimize resource consumption.
Research on product conceptual design scheme configurations from a designer-user conflict perspective
Authors: Pan Sizhe , Shao Hongyu , Song Yufei , Li Quanfu 
Published: March 2024

Abstract
In the context of rapid product iteration, design conflicts arise from discrepancies in designers' understanding of user needs influenced by subjective preferences, behavioural stances, and other factors. This paper proposes a product conceptual design approach based on the design conflict perspective. First, user comments and design documents are collected. Natural language processing (NLP) methods, including cleaning, filtering, lexical segmentation, feature clustering, and sentiment analysis, are employed to identify design themes. The intuitionistic fuzzy sets (IFS) and term frequency-inverse document frequency (TF-IDF) algorithms are then utilized to obtain evaluation matrices for the products from both users and designers. Subsequently, design conflicts between users and designers are calculated, and an optimal configuration for product conceptual design is determined through regression analysis and planning methods. Finally, the proposed method is validated using a mobile phone as a product example, and suggestions for product improvement are presented. The results indicate that considering design conflicts as a factor in product design and synthesizing designer and user product concepts enhances the accuracy and reliability of product conceptual design generation. The findings of this study offer new insights into the conceptual design configuration for product iteration.
Validation of the Extended e-Health Literacy Scale: Structural validity, Construct validity and Measurement Invariance across Age, Gender, and Education
Authors: Petrič Gregor , Atanasova Sara 
Published: March 2024

Abstract

Background
Given the rapid proliferation and use of online health resources, many of which may be of dubious quality, there is an increasing need to develop e-health literacy skills among the population of internet users. E-health literacy encompasses the skills and abilities needed to access, understand, validate, evaluate, interpret, and apply online health-related information. Measuring e-health literacy has become crucial for developing targeted interventions, assessing their impact, and producing high-quality research findings that can inform health policy and practice. The measurement tools need to be valid and reliable so that decisions are based on high-quality data. In this regard, the issue of the measurement equivalence of scales across different demographic groups has been neglected. This is critical, as assessments should be valid across different sociodemographic groups to avoid bias when comparing them. The authors of this study aimed to revise and validate the Extended e-health literacy scale (eHEALS-E); assess its structural, discriminant, and convergent validity; and examine its measurement equivalence across gender, age, and education.
Methods
The data were collected as a part of a national health literacy survey conducted by the Slovenian National Institute of Public Health. Based on a nationally representative sample, the final sample for the analysis comprised 1,944 individuals who at least occasionally used one of the various internet services to obtain health-related information. Multiple group confirmatory factor analysis was used to examine the measurement invariance of the scale.
Results
With some adjustments, the measurement model of the revised 6-dimensional eHEALS-E scale demonstrated a good fit to the data (χ2 = 2508, df = 282, RMSEA = 0.064, SRMR = 0.070, CFI = 0.90). The scale had good internal consistency (alpha = .89). Although evidence of the scale’s convergent and discriminant validity was partially provided, the analysis revealed robust measurement invariance across sociodemographic groups.
Conclusions
With a minor limitation, the instrument ensures an unbiased e-health literacy assessment across different social groups, which is crucial for interventions that aim to reduce health-related social inequalities. This ensures that the interventions derived from the assessment of reality are equally valid and effective for everyone, regardless of their sociodemographic background.
Pan-Arctic Methanesulfonic Acid Aerosol: Source regions, atmospheric drivers, and future projections
Authors: Pernov Jakob Boyd , Harris Eliza , Volpi Michele , Baumgartner Tamara , Hohermuth Benjamin , Henne Stephan , Aeberhard William H. , Becagli Silvia , Quinn Patricia K. , Traversi Rita , Upchurch Lucia M. , Schmale Julia 
Published: March 2024

Abstract

Natural aerosols are an important, yet understudied, part of the Arctic climate system. Natural marine biogenic aerosol components (e.g., methanesulfonic acid, MSA) are becoming increasingly important due to changing environmental conditions. In this study, we combine in situ aerosol observations with atmospheric transport modeling and meteorological reanalysis data in a data-driven framework with the aim to (1) identify the seasonal cycles and source regions of MSA, (2) elucidate the relationships between MSA and atmospheric variables, and (3) project the response of MSA based on trends extrapolated from reanalysis variables and determine which variables are contributing to these projected changes.
We have identified the main source areas of MSA to be the Atlantic and Pacific sectors of the Arctic. Using gradient-boosted trees, we were able to explain 84 % of the variance and find that the most important variables for MSA are indirectly related to either the gas- or aqueous-phase oxidation of dimethyl sulfide (DMS): shortwave and longwave downwelling radiation, temperature, and low cloud cover. We project MSA to undergo a seasonal shift, with non-monotonic decreases in April/May and increases in June-September, over the next 50 years. Different variables in different months are driving these changes, highlighting the complexity of influences on this natural aerosol component. Although the response of MSA due to changing oceanic variables (sea surface temperature, DMS emissions, and sea ice) and precipitation remains to be seen, here we are able to show that MSA will likely undergo a seasonal shift solely due to changes in atmospheric variables.
Twist2 contributes to skin regeneration and hair follicle formation in mouse fetuses
Authors: Takaya Kento , Sunohara Ayano , Sakai Shigeki , Aramaki-Hattori Noriko , Okabe Keisuke , Kishi Kazuo 
Published: March 2024

Abstract
Unlike adult mammalian wounds, early embryonic mouse skin wounds completely regenerate and heal without scars. Analysis of the underlying molecular mechanism will provide insights into scarless wound healing. Twist2 is an important regulator of hair follicle formation and biological patterning; however, whether it plays a role in skin or skin appendage regeneration remains unclear. We aimed to elucidate Twist2 expression and role in fetal wound healing. ICR mouse fetuses were surgically wounded at embryonic days 13 (E13), E15, and E17, and Twist2 expression in tissue samples from these fetuses was evaluated via in situ hybridization, immunohistochemical staining, and reverse transcription-quantitative polymerase chain reaction. Twist2 was upregulated in the dermis of E13 wound margins but downregulated in E15 and E17 wounds. Twist2 knockdown at E13 left visible marks at the wound site, inhibited regeneration, and resulted in defective follicle formation. Twist2-knockdown dermal fibroblasts lacked the ability to undifferentiate. Furthermore, twist2 hetero knockout mice (Twist+/-) formed visible scars, even at E13, where all skin structures, including texture, should regenerate. Thus, Twist2 expression correlated with skin texture formation and hair follicle defects in late mouse embryos. These findings may help develop a therapeutic strategy to reduce scarring and promote hair follicle regeneration.
A Multi-marker Genomic Approach to Decipher the Divergence and Diversity in Selected Allium sativum L. cultivars
Authors: Lekshmi Narayana Chellaiya Johnson Packia , Mahamuni Duraisamy , Brindha Johnson Raja , Rajesh Ramasamy 
Published: March 2024

Abstract

The genus Allium comprises plants of significant economic and medical importance, including onion, garlic, and leek plants. The genetic diversity of garlic plants (Allium sativum) is vital for improving agricultural practices, developing resilient crops, preserving genetic resources, and exploring the full range of culinary and medicinal potential within this important plant species. In this research, we investigated the results of genetic barcoding, focusing on the internal transcribed spacer (ITS) region; four distinct barcoding regions, matK, rbcL, and trnH-psbA; and the trnL and Inter Simple Sequence Repeats (ISSR) regions of Allium sativum L. (Amaryllidaceae), which were collected from three diverse cultivation sites. Our findings revealed significant interspecific diversity and intraspecific divergence among the three cultivars examined. Interestingly, the results from different genetic markers were consistent, with BDUT 1451 and 1452 consistently grouping together, while BDUT 1450 diverged. These findings emphasize the effectiveness of the multi-marker approach for exploring intricate genetic landscapes. Furthermore, they highlight the importance of genetic studies in understanding the diversity of breeding and the potential utility of this economically and medicinally important nutraceutical crop.
The Efficacy of L-glutamine in Osteoarthritis:a comparative analysis with celecoxib and glucosamine sulfate.
Authors: Cheng Wendan , Hu Zhongyao , Wang Changming , wang chen , He Junyan , Yan Yiqun , xu Zelin , yu Yangmang , Zhang Chun , Yu Haoran , Jing Juehua , Yu Ya , Cheng Huan , Liu Lei , Tang Miao 
Published: March 2024

Abstract
Objective: to explore the therapeutic efficacy of L-glutamine (L-Gln) in osteoarthritis(OA), and compare with glucosamine sulfate (GS), and celecoxib (CXB).
Methods: Male SD rats were administered sodium chloride, L-Gln, GS, or CXB via gavage for eight weeks starting in the fifth week after operation. Then the severity of knee OA in rats was evaluated by serological analysis, histological examination and imaging examination. Patients with mild OA were administered L-Gln, GS, or CXB orally for 12 weeks in accordance with the randomization principle. Efficacy end points were the change from baseline to week 24 in the pain and physical function subscale scores of the Western Ontario and McMaster Universities OA Index (WOMAC), and Lequesne score.
Results: The treatment with L-Gln and two other drugs alleviated the increased concentration of serum cartilage degradation markers, cartilage destruction, osteophyte formation, and loss of subchondral bone mass caused by OA in rats. During follow-up, the WOMAC pain and physical function subscale scores and Lequesne score of all three groups of patients decreased from baseline and exceeded the minimum clinical difference. The results indicate that the therapeutic effect of L-Gln is comparable to the other two drugs, and in some indicators, it may even be superior to them.
Conclusion: Our research indicates that L-Gln is comparable to GS and CXB in improving the pathological progression and clinical efficacy of OA. However, L-Gln has a lower occurrence of gastrointestinal adverse reactions and effectively alleviates knee joint pain in OA patients who are unresponsive to NSAIDs and GS. This makes it a promising drug for the treatment of osteoarthritis.
Improving the Function of Thrombosed Aortic Bioprosthetic Valves through Anticoagulation
Authors: Inagaki Masahiro , Ozoe Satoki , Koyama Yutaka , Tomita Shinji 
Published: March 2024

Abstract

Hypoattenuated leaflet thickening (HALT), a potential aftereffect of both surgical and transcatheter bioprosthetic aortic valve procedures, may affect valve performance and clinical outcomes. Here, we describe an elderly patient who, underwent surgical aortic valve replacement with a bioprosthetic valve for aortic stenosis (SAVR), was hospitalized due to heart failure, and complained of worsening dyspnea. The patient’s echocardiography showed an elevated pressure gradient in the aortic valve, while CT revealed HALT on the right coronary cusp of the aortic bioprosthetic valve. Following the diagnosis of a thrombosed bioprosthetic valve, anticoagulation therapy with Coumadin was initiated. The patient's dyspnea symptoms improved, and echocardiography revealed a decreased pressure gradient in the aortic valve three months after starting anticoagulation therapy. This case highlights the significance of considering anticoagulation as the primary treatment option for patients with HALT of a bioprosthetic aortic valve.