bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiplier systems for Siegel modular groups
Authors: Freitag Eberhard , Hauffe-Waschbüsch Adrian 
Published: February 2024

Deligne proved in [Extensions centrales non résiduellement finies de groupes arithmetiques, C. R. Acad. Sci. Paris 287 (1978) 203–208] (see also 7.1 in [R. Hill, Fractional weights and non-congruence subgroups, in Automorphic Forms and Representations of Algebraic Groups Over Local Fields, eds. H. Saito and T. Takahashi, Surikenkoukyuroku Series, Vol. 1338 (2003), pp. 71–80]) that the weights of Siegel modular forms on any congruence subgroup of the Siegel modular group of genus [Formula: see text] must be integral or half integral. Actually he proved that for a system [Formula: see text] of complex numbers of absolute value 1 [Formula: see text] can be an automorphy factor only if [Formula: see text] is integral. We give a different proof for this. It uses Mennicke’s result [Zur Theorie der Siegelschen Modulgruppe, Math. Ann. 159 (1965) 115–129] that subgroups of finite index of the Siegel modular group are congruence subgroups and some techniques from [Solution of the congruence subgroup problem for [Formula: see text] and [Formula: see text], Publ. Math. Inst. Hautes Études Sci. 33 (1967) 59–137] of Bass–Milnor–Serre.
Importance Sampling BRDF Derivatives
Authors: Belhe Yash , Xu Bing , Bangaru Sai Praveen , Ramamoorthi Ravi , Li Tzu-Mao 
Published: February 2024

We propose a set of techniques to efficiently importance sample the derivatives of a wide range of Bidirectional Reflectance Distribution Function (BRDF) models. In differentiable rendering, BRDFs are replaced by their differential BRDF counterparts, which are real-valued and can have negative values. This leads to a new source of variance arising from their change in sign. Real-valued functions cannot be perfectly importance sampled by a positive-valued PDF, and the direct application of BRDF sampling leads to high variance. Previous attempts at antithetic sampling only addressed the derivative with the roughness parameter of isotropic microfacet BRDFs. Our work generalizes BRDF derivative sampling to anisotropic microfacet models, mixture BRDFs, Oren-Nayar, Hanrahan-Krueger, among other analytic BRDFs.
Our method first decomposes the real-valued differential BRDF into a sum of single-signed functions, eliminating variance from a change in sign. Next, we importance sample each of the resulting single-signed functions separately. The first decomposition, positivization, partitions the real-valued function based on its sign, and is effective at variance reduction when applicable. However, it requires analytic knowledge of the roots of the differential BRDF, and for it to be analytically integrable too. Our key insight is that the single-signed functions can have overlapping support, which significantly broadens the ways we can decompose a real-valued function. Our product and mixture decompositions exploit this property, and they allow us to support several BRDF derivatives that positivization could not handle. For a wide variety of BRDF derivatives, our method significantly reduces the variance (up to 58× in some cases) at equal computation cost and enables better recovery of spatially varying textures through gradient-descent-based inverse rendering.
PABPC1L Induces IDO1 to Promote Tryptophan Metabolism and Immune Suppression in Renal Cell Carcinoma
Authors: Shu Guannan , Chen Minyu , Liao Wuyuan , Fu Liangmin , Lin Mingjie , Gui Chengpeng , Cen Junjie , Lu Jun , Chen Zhenhua , Wei Jinhuan , Chen Wei , Wang Yinghan , Zhu Jiangquan , Zhao Tianxin , Liu Xiaonan , Jing Jiajia , Liu Guo-chang , Pan Yihui , Luo Junhang , Zhang Jiaxing 
Published: February 2024

Abstract

The tumor microenvironment (TME) in renal cell carcinomas (RCC) is marked by substantial immunosuppression and immune resistance despite having extensive T-cell infiltration. Elucidation of the mechanisms underlying immune evasion could help identify therapeutic strategies to boost the efficacy of immune checkpoint blockade (ICB) in RCC. This study uncovered a mechanism wherein the polyadenylate-binding protein PABPC1L modulates indoleamine 2,3-dioxygenase 1 (IDO1), a prospective target for immunotherapy. PABPC1L was markedly upregulated in RCC, and high PABPC1L expression correlated with unfavorable prognosis and resistance to ICB. PABPC1L bolstered tryptophan metabolism by upregulating IDO1, inducing T-cell dysfunction and Treg infiltration. PABPC1L enhanced the stability of JAK2 mRNA, leading to increased JAK2-STAT1 signaling that induced IDO1 expression. Additionally, PABPC1L-induced activation of the JAK2-STAT1 axis created a positive feedback loop to promote PABPC1L transcription. Conversely, loss of PABPC1L diminished IDO1 expression, mitigated cytotoxic T-cell suppression, and enhanced responsiveness to anti-PD-1 therapy in patient-derived xenograft models. These findings reveal the crucial role of PABPC1L in facilitating immune evasion in RCC and indicate that inhibiting PABPC1L could be a potential immunotherapeutic approach in combination with ICB to improve patient outcomes.

Significance:
PABPC1L functions as a key factor in renal cell carcinoma immune evasion, enhancing IDO1 and impeding T-cell function, and represents a potential target to enhance the efficacy of immune checkpoint blockade therapy.
Lipid-Encapsulated mRNAs Encoding Complex Fusion Proteins Potentiate Antitumor Immune Responses
Authors: Shuptrine Casey W. , Chen Yuhui , Miriyala Jayalakshmi , Lenz Karen , Moffett Danielle , Nguyen Thuy-Ai , Michaux Jenn , Campbell Kristen , Smith Connor , Morra Marc , Rivera-Molina Yisel , Murr Noah , Cooper Sarah , McGuire Ashlyn , Makani Vishruti , Oien Nathan , Zugates Jeffery T. , de Silva Suresh , Schreiber Taylor H. , de Picciotto Seymour , Fromm George 
Published: February 2024

Abstract

Lipid nanoparticle (LNP)–encapsulated mRNA has been used for in vivo production of several secreted protein classes, such as IgG, and has enabled the development of personalized vaccines in oncology. Establishing the feasibility of delivering complex multispecific modalities that require higher-order structures important for their function could help expand the use of mRNA/LNP biologic formulations. Here, we evaluated whether in vivo administration of mRNA/LNP formulations of SIRPα-Fc-CD40L and TIGIT-Fc-LIGHT could achieve oligomerization and extend exposure, on-target activity, and antitumor responses comparable with that of the corresponding recombinant fusion proteins. Intravenous infusion of the formulated LNP-encapsulated mRNAs led to rapid and sustained production of functional hexameric proteins in vivo, which increased the overall exposure relative to the recombinant protein controls by ∼28 to 140 fold over 96 hours. High concentrations of the mRNA-encoded proteins were also observed in secondary lymphoid organs and within implanted tumors, with protein concentrations in tumors up to 134-fold greater than with the recombinant protein controls 24 hours after treatment. In addition, SIRPα-Fc-CD40L and TIGIT-Fc-LIGHT mRNAs induced a greater increase in antigen-specific CD8+ T cells in the tumors. These mRNA/LNP formulations were well tolerated and led to a rapid increase in serum and intratumoral IL2, delayed tumor growth, extended survival, and outperformed the activities of benchmark mAb controls. Furthermore, the mRNA/LNPs demonstrated improved efficacy in combination with anti-PD-L1 relative to the recombinant fusion proteins. These data support the delivery of complex oligomeric biologics as mRNA/LNP formulations, where high therapeutic expression and exposure could translate into improved patient outcomes.

Significance:
Lipid nanoparticle–encapsulated mRNA can efficiently encode complex fusion proteins encompassing immune checkpoint blockers and costimulators that functionally oligomerize in vivo with extended pharmacokinetics and durable exposure to induce potent antitumor immunity.
DNA of Neutrophil Extracellular Traps Binds TMCO6 to Impair CD8+ T-cell Immunity in Hepatocellular Carcinoma
Authors: Song Mengjia , Zhang Chaoqi , Cheng Shaoyan , Ouyang Dijun , Ping Yu , Yang Jieying , Zhang YaoJun , Tang Yan , Chen Hao , Wang Qi-jing , Li Yong-qiang , He Jia , Xiang Tong , Zhang Yizhuo , Xia Jian-Chuan 
Published: February 2024

Abstract

Neutrophil extracellular traps (NET), formed by the extracellular release of decondensed chromatin and granules, have been shown to promote tumor progression and metastasis. Tumor-associated neutrophils in hepatocellular carcinoma (HCC) are prone to NET formation, highlighting the need for a more comprehensive understanding of the mechanisms of action of NETs in liver cancer. Here, we showed that DNA of NETs (NET-DNA) binds transmembrane and coiled-coil domains 6 (TMCO6) on CD8+ T cells to impair antitumor immunity and thereby promote HCC progression. TGFβ1 induced NET formation, which recruited CD8+ T cells. Binding to NET-DNA inhibited CD8+ T cells function while increasing apoptosis and TGFβ1 secretion, forming a positive feedback loop to further stimulate NET formation and immunosuppression. Mechanistically, the N-terminus of TMCO6 interacted with NET-DNA and suppressed T-cell receptor signaling and NFκB p65 nuclear translocation. Blocking NET formation by inhibiting PAD4 induced potent antitumor effects in wild-type mice but not TMCO6−/− mice. In clinical samples, CD8+ T cells expressing TMCO6 had an exhausted phenotype. TGFβ1 signaling inhibition or TMCO6 deficiency combined with anti-PD-1 abolished NET-driven HCC progression in vivo. Collectively, this study unveils the role of NET-DNA in impairing CD8+ T-cell immunity by binding TMCO6 and identifies targeting this axis as an immunotherapeutic strategy for blocking HCC progression.

Significance:
TMCO6 is a receptor for DNA of NETs that mediates CD8+ T-cell dysfunction in HCC, indicating that the NET-TMCO6 axis is a promising target for overcoming immunosuppression in liver cancer.
Exploiting Tertiary Lymphoid Structures to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy
Authors: Petroni Giulia , Pillozzi Serena , Antonuzzo Lorenzo 
Published: February 2024

Abstract
Tumor-associated tertiary lymphoid structures (TLS) have been associated with favorable clinical outcomes and response to immune checkpoint inhibitors in many cancer types, including non–small cell lung cancer. Although the detailed cellular and molecular mechanisms underlying these clinical associations have not been fully elucidated, growing preclinical and clinical studies are helping to elucidate the mechanisms at the basis of TLS formation, composition, and regulation of immune responses. However, a major challenge remains how to exploit TLS to enhance naïve and treatment-mediated antitumor immune responses. Here, we discuss the current understanding of tumor-associated TLS, preclinical models that can be used to study them, and potential therapeutic interventions to boost TLS formation, with a particular focus on lung cancer research.
Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor–positive Breast Cancer
Authors: Guarducci Cristina , Nardone Agostina , Russo Douglas , Nagy Zsuzsanna , Heraud Capucine , Grinshpun Albert , Zhang Qi , Freelander Allegra , Leventhal Mathew Joseph , Feit Avery , Cohen Feit Gabriella , Feiglin Ariel , Liu Weihan , Hermida-Prado Francisco , Kesten Nikolas , Ma Wen , De Angelis Carmine , Morlando Antonio , O'Donnell Madison , Naumenko Sergey , Huang Shixia , Nguyen Quang-Dé , Huang Ying , Malorni Luca , Bergholz Johann S. , Zhao Jean J. , Fraenkel Ernest , Lim Elgene , Schiff Rachel , Shapiro Geoffrey I. , Jeselsohn Rinath 
Published: February 2024

Abstract

Purpose:
Resistance to endocrine therapy (ET) and CDK4/6 inhibitors (CDK4/6i) is a clinical challenge in estrogen receptor (ER)-positive (ER+) breast cancer. Cyclin-dependent kinase 7 (CDK7) is a candidate target in endocrine-resistant ER+ breast cancer models and selective CDK7 inhibitors (CDK7i) are in clinical development for the treatment of ER+ breast cancer. Nonetheless, the precise mechanisms responsible for the activity of CDK7i in ER+ breast cancer remain elusive. Herein, we sought to unravel these mechanisms.

Experimental Design:
We conducted multi-omic analyses in ER+ breast cancer models in vitro and in vivo, including models with different genetic backgrounds. We also performed genome-wide CRISPR/Cas9 knockout screens to identify potential therapeutic vulnerabilities in CDK4/6i-resistant models.

Results:
We found that the on-target antitumor effects of CDK7 inhibition in ER+ breast cancer are in part p53 dependent, and involve cell cycle inhibition and suppression of c-Myc. Moreover, CDK7 inhibition exhibited cytotoxic effects, distinctive from the cytostatic nature of ET and CDK4/6i. CDK7 inhibition resulted in suppression of ER phosphorylation at S118; however, long-term CDK7 inhibition resulted in increased ER signaling, supporting the combination of ET with a CDK7i. Finally, genome-wide CRISPR/Cas9 knockout screens identified CDK7 and MYC signaling as putative vulnerabilities in CDK4/6i resistance, and CDK7 inhibition effectively inhibited CDK4/6i-resistant models.

Conclusions:
Taken together, these findings support the clinical investigation of selective CDK7 inhibition combined with ET to overcome treatment resistance in ER+ breast cancer. In addition, our study highlights the potential of increased c-Myc activity and intact p53 as predictors of sensitivity to CDK7i-based treatments.
Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
Authors: Li Tao , Wei Lei , Zhang Xin , Fu Bin , Zhou Yunjiang , Yang Mengdi , Cao Mengran , Chen Yaxin , Tan Yingying , Shi Yongwei , Wu Leyin , Xuan Chenyuan , Du Qianming , Hu Rong 
Published: February 2024

Abstract

A number of neurotransmitters have been detected in tumor microenvironment and proved to modulate cancer oncogenesis and progression. We previously found that biosynthesis and secretion of neurotransmitter 5-hydroxytryptamine (5-HT) was elevated in colorectal cancer cells. In this study, we discovered that the HTR2B receptor of 5-HT was highly expressed in colorectal cancer tumor tissues, which was further identified as a strong risk factor for colorectal cancer prognostic outcomes. Both pharmacological blocking and genetic knocking down HTR2B impaired migration of colorectal cancer cell, as well as the epithelial–mesenchymal transition (EMT) process. Mechanistically, HTR2B signaling induced ribosomal protein S6 kinase B1 (S6K1) activation via the Akt/mTOR pathway, which triggered cAMP-responsive element-binding protein 1 (CREB1) phosphorylation (Ser 133) and translocation into the nucleus, then the phosphorylated CREB1 acts as an activator for ZEB1 transcription after binding to CREB1 half-site (GTCA) at ZEB1 promoter. As a key regulator of EMT, ZEB1, therefore, enhances migration and EMT process in colorectal cancer cells. We also found that HTR2B-specific antagonist (RS127445) treatment significantly ameliorated metastasis and reversed EMT process in both HCT116 cell tail-vein–injected pulmonary metastasis and CT26 cell intrasplenic-injected hepatic metastasis mouse models.

Implications:
These findings uncover a novel regulatory role of HTR2B signaling on colorectal cancer metastasis, which provide experimental evidences for potential HTR2B-targeted anti-colorectal cancer metastasis therapy.
Indigenous Clockmakers, Schedules, and Quantitative Time in the Spanish Colonies (16th Century)
Authors: Uribe Ricardo 
Published: February 2024

Abstract
During the 16th century, the term “Cemilhuitlapohualtepoztli” meant “clock” to the indigenous peoples of Mexico. They had formed this neologism out of three words from the Nahual language: “cemilhui” (the passing of a day); “tlapoaliztli” (to count); and “tepoztli” (bell or iron). This linguistic evidence, in conjunction with other documents found in Spanish and Latin American archives, show that autochthonous people came into early contact with these mechanisms and promptly assimilated quantified time. Historiography often claims that the Catholic Church imposed this kind of time among indigenous societies, however, this paper demonstrates that indigenous peoples appropriated a more precise and quantified time in the offices of the colonial administration, either by working as clockmakers or by producing “timetables” and calendars. This process allowed, on the one hand, the global synchrony between the Old and the New World, and on the other hand, the coordination of collective temporalities and local calendars.
Time Experiencing in Men Serving the Term of Imprisonment – a Semantic Differential Study
Authors: Tucholska Kinga , Gulla Bożena , Wysocka-Pleczyk Małgorzata , Piotrowski Przemysław , Florek Stefan , Sekulak Martyna , Głomb Kaja 
Published: February 2024

Abstract
This paper proposes a semantic differential-based research method called Prison Time. The study with this tool was conducted on a group (N = 161) of men serving time in Polish prisons. The analysis revealed a two-factor structure accounting for 49.1% of the variance, with Cronbach’s alpha greater than 0.74. The Perceptual-Formal factor reflects formal aspects of perceiving time – pace, dynamics, and changeability. The Emotional-Valence factor captures both the emotional load and assessment related to experiencing imprisonment time. The measure is likely to be used by both academics and practitioners interested in assessing the subjective attitude to time as experienced in prison.
A revision of the Trioserica species from continental southeast Asia (Coleoptera: Scarabaeidae: Sericinae: Sericini)1
Authors: Ahrens Dirk , Lukic Daniel , Wipfler Benedict , Pham Phu 
Published: February 2024

Abstract
The current paper gives an overview of the species so far assigned to the genus Trioserica Moser, 1922 which occur in continental southeast Asia. The types of the known species are revised and 42 new species are described: Trioserica achterbergi Ahrens, Lukic & Pham, sp. n., T. bachma Ahrens, Lukic & Pham, sp. n., T. bansongcha Ahrens, Lukic & Pham, sp. n., T. bresseeli Ahrens, Lukic & Pham, sp. n., T. chaudoc Ahrens, Lukic & Pham, sp. n., T. chaweewanae Ahrens, Lukic & Pham, sp. n., T. chumomray Ahrens, Lukic & Pham, sp. n., T. chuyangsin Ahrens, Lukic & Pham, sp. n., T. csorbai Ahrens, Lukic & Pham, sp. n., T. dalat Ahrens, Lukic & Pham, sp. n., T. dongnai Ahrens, Lukic & Pham, sp. n., T. geiseri Ahrens, Lukic & Pham, sp. n., T. guerlaechi Ahrens, Lukic & Pham, sp. n., T. hartmanni Ahrens, Lukic & Pham, sp. n., T. huaypok Ahrens, Lukic & Pham, sp. n., T. khaoyai Ahrens, Lukic & Pham, sp. n., T. konplongensis Ahrens, Lukic & Pham, sp. n., T. lamdongensis Ahrens, Lukic & Pham, sp. n., T. namphak Ahrens, Lukic & Pham, sp. n., T. nongfa Ahrens, Lukic & Pham, sp. n., T. pahinngam Ahrens, Lukic & Pham, sp. n., T. pakse Ahrens, Lukic & Pham, sp. n., T. paulseni Ahrens, Lukic & Pham, sp. n., T. phataem Ahrens, Lukic & Pham, sp. n., T. phetchabun Ahrens, Lukic & Pham, sp. n., T. phnomkulen Ahrens, Lukic & Pham, sp. n., T. phuphan Ahrens, Lukic & Pham, sp. n., T. pongpitaki Ahrens, Lukic & Pham, sp. n., T. preahkhan Ahrens, Lukic & Pham, sp. n., T. prome Ahrens, Lukic & Pham, sp. n., T. samoeng Ahrens, Lukic & Pham, sp. n., T. sanogae Ahrens, Lukic & Pham, sp. n., T. seideli Ahrens, Lukic & Pham, sp. n., T. sekongensis Ahrens, Lukic & Pham, sp. n., T. skalei Ahrens, Lukic & Pham, sp. n., T. tadfaek Ahrens, Lukic & Pham, sp. n., T. tenasserim Ahrens, Lukic & Pham, sp. n., T. theinzek Ahrens, Lukic & Pham, sp. n., T. tongbiguan Ahrens, Lukic & Pham, sp. n., T. vientiane Ahrens, Lukic & Pham, sp. n., T. vriesi Ahrens, Lukic & Pham, sp. n., T. vuquang Ahrens, Lukic & Pham, sp. n. The revision resulted also in three new combinations: Trioserica rugosa (Brenske, 1899) comb. n., T. maculata (Frey, 1972) comb. n. and T. minima (Frey, 1972) comb. n. A key to the species of continental SE Asia is given. The diagnostic characters of the newly revised taxa and their distribution are illustrated.
Becoming Europeanized Muslims
Authors: Musahadi Musahadi , Junaidi Akhmad Arif 
Published: February 2024

Abstract
This article aims to provide insight into the formation of religious identity among the millennial generation of the Indonesian Muslim diaspora in the Netherlands, identifying its main influencing factors. Our empirical study identified a dynamic and diverse process regarding the formation of the millennial group’s religious identity, expressed dynamically in various aspects of Islamic teachings at the level of religious beliefs, morals or ethics, and practices. The negotiation process between their Islamic and Western identities produced various identity statuses, namely diffusion, foreclosure, moratorium, and achievement. The process shifts between exploration and commitment. The study concludes that religious identities formed through exploration are more established and more adaptable to environmental changes than those based on commitment with no exploration. Second, the formation of the Indonesian Muslim millennial diaspora’s religious identity is influenced by three key factors, namely social environment, reference groups, and role models.
Semantic Derivation Strategies of Verbs of Smell Emission in the Polish and Ukrainian Languages
Authors: Demenchuk Oleh 
Published: February 2024

Semantic Derivation Strategies of Verbs of Smell Emission in the Polish and Ukrainian Languages
The article focuses on the strategies of semantic derivation of verbs of smell emission – a semantic class of words that denote a situation of smell emission and its perception. The study reveals the features of verbs of smell emission and characterizes their semantic shifts in the Polish and Ukrainian languages. We posit that a linguistic item’s semantic paradigm development aligns with situation concept extensions, which are supposed to be determined by the changes participants undergo within source-to-target-situation shifts. The semantic shifts construed by Polish and Ukrainian verbs of smell emission suggest the regular direction of concept extensions – from an internal domain (a situation of smell emission and its perception) via an adjacent one (smell identification) towards an external (smell interpretation) domain.

Strategie derywacji semantycznej czasowników emisji zapachu w języku polskim i ukraińskim
W artykule skupiono się na strategiach derywacji semantycznej czasowników emisji zapachu – słów oznaczających sytuację wydzielania zapachu i jego percepcji. W pracy ukazano cechy czasowników emisji zapachu oraz scharakteryzowano ich zmiany semantyczne w języku polskim i ukraińskim. Rozszerzenia pojęcia sytuacji emisji zapachu są zdeterminowane przez zmiany charakterystyk uczestników sytuacji. Przesunięcia semantyczne sugerują regularny kierunek rozszerzeń – od domeny wewnętrznej (sytuacja emisji zapachu i jego percepcji) przez dziedzinę przyległą (identyfikacja zapachu) w kierunku domeny zewnętrznej (interpretacja zapachu).
Areal Clustering of the Slavic Phonetics
Authors: Sawicka Irena 
Published: February 2024

Areal Clustering of Slavic Phonetics
The article succinctly discusses the most important phonetic features of Slavic languages and indicates their geographical distribution. It briefly presents an area-typological view of the contemporary phonetics of Slavic languages and suggests a different division than the one resulting from historical facts (into eastern, western, and southern groups).

Arealno-typologiczne rozczłonkowanie słowiańskiej fonetyki
Artykuł krótko omawia najistotniejsze cechy fonetyczne słowiańskiego obszaru językowego i ich dystrybucję arealną. Prezentuje arealno-typologiczne podejście do tematu, sugerując w konkluzji inne współczesne podziały niż te, jakie wynikają z faktów historycznych (tj. podział na grupę zachodnio-, wschodnio- i południowosłowiańską).