bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-traumatic complete cervical spine dislocation with severe fixed kyphosis: successful multidisciplinary approach to a challenging case
Authors: Lecouvet Camille , Geradon Pierre , Banse Xavier , Rausin Gauthier , Guyot Nicolas , Lecouvet Frederic E. 
Published: April 2024

Abstract
Background
To our knowledge, there is no previous report in the literature of non-traumatic neglected complete cervical spine dislocation characterized by anterior spondyloptosis of C4, extreme head drop, and irreducible cervicothoracic kyphosis.

Case presentation
We report the case of a 33-year-old Caucasian man with a 17-year history of severe immune polymyositis and regular physiotherapy who presented with severe non-reducible kyphosis of the cervicothoracic junction and progressive tetraparesia for several weeks after a physiotherapy session. Radiographs, computed tomography, and magnetic resonance imaging revealed a complete dislocation at the C4–C5 level, with C4 spondyloptosis, kyphotic angulation, spinal cord compression, and severe myelopathy. Due to recent worsening of neurological symptoms, an invasive treatment strategy was indicated. The patient’s neurological status and spinal deformity greatly complicated the anesthetic and surgical management, which was planned after extensive multidisciplinary discussion and relied on close collaboration between the orthopedic surgeon and the anesthetist. Regarding anesthesia, difficult airway access was expected due to severe cervical angulation, limited mouth opening, and thyromental distance, with high risk of difficult ventilation and intubation. Patient management was further complicated by a theoretical risk of neurogenic shock, motor and sensory deterioration, instability due to position changes during surgery, and postoperative respiratory failure. Regarding surgery, a multistage approach was carefully planned. After a failed attempt at closed reduction, a three-stage surgical procedure was performed to reduce displacement and stabilize the spine, resulting in correct spinal realignment and fixation. Progressive complete neurological recovery was observed.

Conclusion
This case illustrates the successful management of a critical situation based on a multidisciplinary collaboration involving radiologists, anesthesiologists, and spine surgeons.
Administration of adipose-derived stem cells extracellular vesicles in a murine model of spinal muscular atrophy: effects of a new potential therapeutic strategy
Authors: Virla Federica , Turano Ermanna , Scambi Ilaria , Schiaffino Lorenzo , Boido Marina , Mariotti Raffaella 
Published: April 2024

Abstract
Background
Spinal Muscular Atrophy (SMA) is an autosomal-recessive neuromuscular disease affecting children. It is caused by the mutation or deletion of the survival motor neuron 1 (SMN1) gene resulting in lower motor neuron (MN) degeneration followed by motor impairment, progressive skeletal muscle paralysis and respiratory failure. In addition to the already existing therapies, a possible combinatorial strategy could be represented by the use of adipose-derived mesenchymal stem cells (ASCs) that can be obtained easily and in large amounts from adipose tissue. Their efficacy seems to be correlated to their paracrine activity and the production of soluble factors released through extracellular vesicles (EVs). EVs are important mediators of intercellular communication with a diameter between 30 and 100 nm. Their use in other neurodegenerative disorders showed a neuroprotective effect thanks to the release of their content, especially proteins, miRNAs and mRNAs.

Methods
In this study, we evaluated the effect of EVs isolated from ASCs (ASC-EVs) in the SMNΔ7 mice, a severe SMA model. With this purpose, we performed two administrations of ASC-EVs (0.5 µg) in SMA pups via intracerebroventricular injections at post-natal day 3 (P3) and P6. We then assessed the treatment efficacy by behavioural test from P2 to P10 and histological analyses at P10.

Results
The results showed positive effects of ASC-EVs on the disease progression, with improved motor performance and a significant delay in spinal MN degeneration of treated animals. ASC-EVs could also reduce the apoptotic activation (cleaved Caspase-3) and modulate the neuroinflammation with an observed decreased glial activation in lumbar spinal cord, while at peripheral level ASC-EVs could only partially limit the muscular atrophy and fiber denervation.

Conclusions
Our results could encourage the use of ASC-EVs as a therapeutic combinatorial treatment for SMA, bypassing the controversial use of stem cells.
DeepDet: YAMNet with BottleNeck Attention Module (BAM) for TTS synthesis detection
Authors: Mahum Rabbia , Irtaza Aun , Javed Ali , Mahmoud Haitham A. , Hassan Haseeb 
Published: April 2024

AbstractSpoofed speeches are becoming a big threat to society due to advancements in artificial intelligence techniques. Therefore, there must be an automated spoofing detector that can be integrated into automatic speaker verification (ASV) systems. In this study, we recommend a novel and robust model, named DeepDet, based on deep-layered architecture, to categorize speech into two classes: spoofed and bonafide. DeepDet is an improved model based on Yet Another Mobile Network (YAMNet) employing a customized MobileNet combined with a bottleneck attention module (BAM). First, we convert audio into mel-spectrograms that consist of time–frequency representations on mel-scale. Second, we trained our deep layered model using the extracted mel-spectrograms on a Logical Access (LA) set, including synthesized speeches and voice conversions of the ASVspoof-2019 dataset. In the end, we classified the audios, utilizing our trained binary classifier. More precisely, we utilized the power of layered architecture and guided attention that can discern the spoofed speech from bonafide samples. Our proposed improved model employs depth-wise linearly separate convolutions, which makes our model lighter weight than existing techniques. Furthermore, we implemented extensive experiments to assess the performance of the suggested model using the ASVspoof 2019 corpus. We attained an equal error rate (EER) of 0.042% on Logical Access (LA), whereas 0.43% on Physical Access (PA) attacks. Therefore, the performance of the proposed model is significant on the ASVspoof 2019 dataset and indicates the effectiveness of the DeepDet over existing spoofing detectors. Additionally, our proposed model is robust enough that can identify the unseen spoofed audios and classifies the several attacks accurately.
Spatial analysis of outdoor indecent assault risk: a study using ambient population data
Authors: Adachi Hiroki M. , Nakaya Tomoki 
Published: April 2024

AbstractSpatiotemporal data on ambient populations have recently become widely available. Although previous studies have indicated a link between the spatial patterns of crime occurrence and ambient population distribution, more detailed information, such as the population most likely to be victims by gender and age group, could better predict the risk of crime occurrence. Therefore, this study aimed to analyze the risk of indecent assault, a typical crime with a high number of young female victims, in southern Kyoto Prefecture. We utilized population distribution by gender and age group at different times of the day. After extracting daily patterns (factors) of the population using non-negative matrix factorization, we statistically modeled the risk of indecent assault using a spatial conditional autoregressive model. The results showed that the model, which considered a spatiotemporal ambient population, demonstrated superior performance during nighttime hours. Furthermore, by interpreting the factors significantly associated with the risk of crime occurrence, the findings provided valuable insights into local crime prevention measures that consider daily temporal changes in the gender and age-group composition of individuals present in a specific area.
Decoding populations in the ocean microbiome
Authors: Logares Ramiro 
Published: April 2024

AbstractUnderstanding the characteristics and structure of populations is fundamental to comprehending ecosystem processes and evolutionary adaptations. While the study of animal and plant populations has spanned a few centuries, microbial populations have been under scientific scrutiny for a considerably shorter period. In the ocean, analyzing the genetic composition of microbial populations and their adaptations to multiple niches can yield important insights into ecosystem function and the microbiome's response to global change. However, microbial populations have remained elusive to the scientific community due to the challenges associated with isolating microorganisms in the laboratory. Today, advancements in large-scale metagenomics and metatranscriptomics facilitate the investigation of populations from many uncultured microbial species directly from their habitats. The knowledge acquired thus far reveals substantial genetic diversity among various microbial species, showcasing distinct patterns of population differentiation and adaptations, and highlighting the significant role of selection in structuring populations. In the coming years, population genomics is expected to significantly increase our understanding of the architecture and functioning of the ocean microbiome, providing insights into its vulnerability or resilience in the face of ongoing global change.
Factors influencing root resorption in retained mandibular second deciduous molars with congenital absence of second premolars: a cross-sectional study
Authors: Ishizuka Keita , Kato Chiho , Fujita Akiyo , Misawa-Omori Eri , Ono Takashi 
Published: April 2024

Abstract
Background
There are currently no studies that quantitatively compare the relationship of root resorption to the patient’s systemic history or craniofacial and intraoral morphology, especially in relation to possible host factors. Thus, this study aimed to clarify the factors associated with root resorption in retained mandibular second deciduous molars with the congenital absence of second premolars and predict the prognosis of retained mandibular second deciduous molars.

Methods
A cohort of 5547 patients who visited the orthodontic clinic at Tokyo Medical and Dental University Dental Hospital between 2013 and 2022 was screened. Lateral cephalometric radiographs, panoramic radiographs, upper and lower dental models, and orthodontic treatment questionnaires were used as reference materials to apply the inclusion and exclusion criteria. Ultimately, 111 patients were included in the analyses. The patients were divided into two groups based on the root resorption levels of the retained mandibular second deciduous molars. Those with less root resorption were classified under the good condition (GC) group, whereas those with more root resorption were classified under the poor condition (PC) group. Demographic, clinical, and cephalometric parameters were compared between the groups. A multivariate logistic regression model was used to predict the probability of root resorption.

Results
The prevalence of congenitally missing mandibular second premolars with persistent mandibular second deciduous molars was 2.0%. In a total of 111 patients, eighty-three teeth (53.2%) were classified into the GC group, whereas 73 teeth (46.8%) were classified into the PC group. The Frankfort-mandibular plane angle (FMA) [odds ratio (OR): 0.87], Frankfort-mandibular incisor angle (FMIA) (OR: 0.93), overbite (OR: 1.38), adjacent interdental space (OR: 1.46), distance from occlusal plane (OR: 0.80), and caries treatment (OR: 7.05) were significantly associated with the root resorption of the retained mandibular second deciduous molars.

Conclusions
Our findings suggest that skeletal morphology, oral morphological patterns, and history contribute to root resorption in retained mandibular second deciduous teeth with congenital absence of subsequent permanent teeth.
The limits of inference: reassessing causality in international assessments
Authors: Rutkowski David , Rutkowski Leslie , Thompson Greg , Canbolat Yusuf 
Published: April 2024

AbstractThis paper scrutinizes the increasing trend of using international large-scale assessment (ILSA) data for causal inferences in educational research, arguing that such inferences are often tenuous. We explore the complexities of causality within ILSAs, highlighting the methodological constraints that challenge the validity of causal claims derived from these datasets. The analysis begins with an overview of causality in relation to ILSAs, followed by an examination of randomized control trials and quasi-experimental designs. We juxtapose two quasi-experimental studies demonstrating potential against three studies using ILSA data, revealing significant limitations in causal inference. The discussion addresses the ethical and epistemological challenges in applying quasi-experimental designs to ILSAs, emphasizing the difficulty in achieving robust causal inference. The paper concludes by suggesting a framework for critically evaluating quasi-experimental designs using ILSAs, advocating for a cautious approach in employing these data for causal inferences. We call for a reevaluation of methodologies and conceptual frameworks in comparative education, underscoring the need for a multifaceted approach that combines statistical rigor with an understanding of educational contexts and theoretical foundations.
Science teacher identity research: a scoping literature review
Authors: Zhai Yanfang , Tripp Jennifer , Liu Xiufeng 
Published: April 2024

AbstractScience teacher identity significantly influences teacher professional development, practices, and attitudes, which in turn impacts student learning outcomes. With an increased number of studies on science teacher identity over the past two decades, there is a need for a scoping literature review that holistically maps the current state of science teacher identity research and identifies future research directions. This scoping literature review identified 48 empirical articles on science teacher identity, published from 2000 to 2023, in peer-reviewed journals and examined the studies’ (a) characteristics; (b) theoretical frameworks on identity; (c) definitions of science teacher identity; and (d) major findings. Specifically, there is a need for precise conceptualizations and definitions of science teacher identity; this clarity will facilitate valid, reliable, and fair instruments to capture the relatively stable facets of science teacher identity at a given moment in a given context in order to longitudinally track science teacher identity development. This scoping review identifies both progress and gaps in the current literature and future directions for synergistic, cross-cultural international research on science teacher identity.
A case of pancreatic adenosquamous cell carcinoma with a pseudocyst following curative surgery
Authors: Kitasaki Nao , Abe Tomoyuki , Inoue Masashi , Teshima Marino , Nakagawa Masataka , Kochi Masatoshi , Hotta Ryuichi , Toyota Kazuhiro 
Published: April 2024

Abstract
Background
Pancreatic adenosquamous cell carcinoma (PASC) is a relatively rare histological type of pancreatic malignancy, and preoperative diagnosis is difficult because of its rarity. PASC accounts for 1–4% of all pancreatic cancers, and even after curative surgery, its prognosis is poorer than that of ordinary pancreatic adenocarcinoma. Pathologically, it shows glandular and squamous differentiation of cells. Complete resection is the only method to achieve a good long-term prognosis, and an increasing doubling time of PASC is considered to indicate early recurrence after surgery. Here, we report a rare case of PASC with an infected pancreatic cyst that was difficult to treat, along with a review of the literature.

Case presentation
A woman in her 80s with a history of breast cancer presented with pericardial pain. Computed tomography revealed a 20-mm hypovascular tumor in the body of the pancreas and a 27-mm pseudocyst. Endoscopic retrograde cholangiopancreatography showed a severe main pancreatic duct stenosis in the body of the pancreas that made cannulation impossible, and contrast media extravasation was due to pancreatic duct disruption in the pancreatic tail. Endoscopic fine-needle aspiration revealed that the tumor was a PASC. Because the patient had an infected pancreatic cyst, central intravenous nutrition and antibiotics were administered, which stabilized her general condition. She was diagnosed with resectable PASC and underwent distal pancreatectomy with lymphadenectomy. The postoperative course was uneventful. Immunohistochemical analysis of the resected specimen confirmed T2N0M0 stage IB. Systemic adjuvant chemotherapy with S-1 is ongoing.

Conclusion
Appropriate preoperative management and preoperative accurate staging (T2N0M0 stage IB) of PASC with curative surgery can ensure predictable outcomes.
The credit card-augmented Divisia monetary aggregates: an analysis based on recurrence plots and visual boundary recurrence plots
Authors: Andreadis Ioannis , Fragkou Athanasios D. , Karakasidis Theodoros E. , Serletis Apostolos 
Published: April 2024

AbstractIn this paper, we compare the dynamics of the growth rates of the original Divisia monetary aggregates, the credit card-augmented Divisia monetary aggregates, and the credit card-augmented Divisia inside monetary aggregates. This analysis is based on the methods of recurrence plots, recurrence quantification analysis, and visual boundary recurrence plots which are phase space methods designed to depict the underlying dynamics of the system under study. We identify the events that affected Divisia money growth and point out the differences among the different Divisia monetary aggregates based on the recurrence and visual boundary recurrence plots. We argue that the broad Divisia monetary aggregates could be used for monetary policy and business cycle analysis as they are exhibiting less fluctuation compared to the narrow Divisia monetary aggregates. They could positively affect policy decisions regarding environmental choices and sustainability. We also point out the changes in the monetary dynamics locating the 2008 global financial crisis and the Covid-19 pandemic.
When and how to use ambulatory blood pressure monitoring and home blood pressure monitoring for managing hypertension
Authors: Lee Eun Mi 
Published: April 2024

AbstractMany individuals have different blood pressure (BP) values in the office setting compared to that outside the office setting. Therefore, confirming hypertension based on office BP (OBP) measurement alone can lead to misdiagnosis and mistreatment. The limitations of OBP measurement have led to the complementary use of out-of-office BP measurements, including 24-hour ambulatory blood pressure monitoring (ABPM) and home blood pressure monitoring (HBPM). This review aims to describe when and how ABPM or HBPM can be used to accurately diagnose and treat hypertension. Both methods should be performed using validated automated oscillometric devices. To minimize user errors, ABPM should be performed using standard techniques, whereas HBPM requires patient education regarding proper BP measurements. ABPM provides short-term comprehensive information on BP, including daytime, nighttime, morning, and 24-h BP. Therefore, ABPM is recommended for the initial diagnosis of hypertension, assessment of BP phenotypes and circadian patterns, and detection of nocturnal hypertension, Furthermore, ABPM plays a critical role in confirming true resistant hypertension thereby excluding pseudo-resistant hypertension. However, it is not suitable for long-term follow-up of patients with hypertension. In contrast, HBPM involves multiple BP readings taken at specific times during the day and evening over a long period. Therefore, HBPM is recommended for diagnosing hypertension and assessing BP phenotypes. However, this method has limitations in measuring nocturnal BP and circadian BP patterns. HBPM is preferred over ABPM for the long-term follow-up of patients with hypertension. This approach improves patient adherence to treatment and ultimately enhances the rate of control of hypertension. Additionally, both methods play an important role in diagnosing and treating white coat hypertension during pregnancy. Consequently, out-of-office BP measurement is essential to prevent the misdiagnosis and mistreatment of hypertension. However, these two methods offer different information regarding the BP status of an individual, and they indeed show discrepancies in the diagnosis of hypertensive phenotypes. Therefore, it is crucial to understand the advantages and limitations of both ABPM and HBPM to ensure their appropriate use in clinical practice.
Graphical Abstract
Biodegradability of leather: a crucial indicator to evaluate sustainability of leather
Authors: Wang Ya-nan , Zhang Yuxin , Wang Zhen 
Published: April 2024

AbstractBiodegradability is a crucial indicator to evaluate the sustainability of leather. Herein, a rapid method for biodegradation test in an aqueous medium by measuring biochemical oxygen demand was used to determine the biodegradability of leather from different tanning methods, tanning conditions and process stages. In addition, the difference in biodegradability between leather and leather-like synthetic materials were investigated. Chrome-free tanned leather showed higher degree of biodegradation and faster biodegradation rate than chrome tanned leather. Among them, leathers tanned with biomass-based tanning agents were much easier to biodegrade because the crosslinking network of tanned leather constructed with biomass was more susceptible to microbial attack. The enhancement of tanning effects through changing tanning methods and conditions (such as tanning agent dosage, pH and temperature) resulted in the decline of leather biodegradability. Future development of novel chrome-free tanning technologies should balance between these two aspects. The biodegradability of leather from tanning to post-tanning to finishing showed a stepwise decrease because various chemicals were applied and bound to leather during processing. Even so, finished leather still possessed significantly higher biodegradability compared to leather-like PU and microfiber synthetic materials, demonstrating superior environmental sustainability of natural leather. The results are expected to provide support for the evaluation of the ecological properties of leather and green upgrade of the leather industry.
Graphical abstract