bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do Economic Complexity Drivers Differ by Income Level? Insights From a Global Perspective
Authors: Şanlı Devran , Gülbay Yiğiteli Nadide , Ergün Tatar Havanur 
Published: April 2024

This study examines the drivers of economic complexity for 97 countries over the period 1995 to 2020 by income sub-groups. To investigate determinants of complexity, we develop five novel indexes. Using two-step system GMM (2SGMM) regression with the robust standard errors method, we found that institutional quality, health dimensions and macroeconomic conditions were enormously significant economic complexity drivers. However, the findings vary according to the country groups with different income levels. While the importance of openness and health dimensions are prominent in low and middle-income countries, capital stock and openness are the principal elements in the high-income group. The institutional quality is statistically significant and considerably affects on complexity in each group and across the panel. The education dimension of human capital has a positive effect only in the high-income group and across the panel, while it is negative in the middle and low-income groups, but its effect is weak. Moreover, these findings are valid in the long run. From a policy perspective, the findings suggest that macroeconomic policies focused on institutional quality, openness and healthcare as critical components of economic complexity should be crucial goals, especially for low and middle-income countries. JEL Classification: O11, O43, I15, I25.
Being a Newly Qualified Nurse: A Nordic Focus Group Study
Authors: Tast Anette , Kasén Anne , Bölenius Karin , Hilli Yvonne 
Published: April 2024

Introduction The transition to working life as a newly qualified nurse (NQN) can be challenging, leading to heightened stress levels. While NQNs are generally enthusiastic about starting their careers, they often express concerns about various responsibilities and a perceived lack of experience in independently dealing with clinical care in complex environments. Objective To acquire an in-depth understanding, from a caring science perspective, of what it means to be an NQN during the transition period of the first 18 months in the profession. Methods This study relied on an exploratory qualitative design. The methodological approach followed Gadamer's hermeneutic philosophy. Six focus group interviews were conducted in northern Norway (n = 3) and northern Sweden (n = 3) from January through May 2021. The interpretation of the data was inspired by Fleming et al. Nineteen female and seven male NQNs working in different contexts, including hospitals and municipalities, participated in the study. The consolidated criteria for qualitative research were used to report the results. Results Perspectives on NQNs are presented as three themes: a) the responsibility was perceived as a significant challenge, b) being a nurse is complex and demanding, and c) a desire for personal and professional development. Learning to be a nurse shouldering responsibility necessitates support and guidance from caring and compassionate colleagues and leaders. Conclusions This study sheds light on the importance of creating a workplace culture where NQNs’ learning is promoted and supported by designated mentors during their transition to working life. The responsibilities should be aligned with their level of knowledge. It is important that leaders hold developmental dialogues and ensure a career plan for NQNs to continuously develop their knowledge and skills. Intervention studies designed to evaluate the meaning of the support from appointed mentors within structured mentorship programs are needed.
Long-Term Outcomes of Nitrous Oxide Cryoballoon Ablation of Barrett’s Esophagus-Associated Early Adenocarcinoma After Attempted Curative Endoscopic Mucosal Resection
Authors: Almario Jose Antonio , Swei Eric , Finney Amanda Grace , Canto Marcia Irene 
Published: April 2024

Objective: Nitrous oxide cryoballoon ablation (CBA) is an effective therapy for Barrett’s esophagus (BE). Data regarding the efficacy of CBA for complete eradication of BE-associated intramucosal adenocarcinoma (ImCA) after endoscopic mucosal resection (EMR) are limited. Our aim is to determine the eradication rates of CBA for ImCA after unsuccessful attempted EMR. Methods: In this retrospective study we analyzed data from the electronic medical record of patients with ImCA who were treated with CBA as primary or rescue ablative therapy at a tertiary care academic center between July 2014 and September 2022. The primary outcome was complete eradication of ImCA (CE-CA). Secondary outcomes included eradication rate of intestinal metaplasia, recurrence rate of cancer and intestinal metaplasia, cancer-related morality, and disease-specific survival. Results: Thirty-five patients were included in the study. Group 1: 23 patients with EMR with positive margins. Group 2: 12 patients with unlocalized biopsy-proven ImCA. The median pre-CBA Prague C and M were 2 cm (SD ± 3.6) and 4.0 cm (SD ± 4). 21 (91%) patients in Group 1 achieved CE-CA within 1 year after a median 3 (IQR 2) CBA sessions. BE-CA related mortality was zero. There were no cases of recurrent intraluminal or extraluminal CA. 32 patients achieved and maintained CE-CA, while 23 (65.7%) achieved CE-IM by year 1. Conclusion: In our cohort, CBA was safe and effective for cancer and intestinal metaplasia eradication up to 5 years from initial treatment. Prospective studies are needed to assess the role of CBA in endoscopic therapy of early esophageal cancer.
Composition and paragenesis of daqingshanite from the Kamthai carbothermalite, Rajasthan, India
Authors: Mitchell Roger H. 
Published: April 2024

AbstractDaqingshanite in the Kamthai REE deposit (India) occurs as two paragenetic types: primary granular coarse grained crystals coexisting with primary carbocernaite, baryte and bastnäsite; and as aligned micro-ovoid globules within clasts of Sr-bearing calcite. Carbocernaite forming trellis-type lamellae in some of these calcite clasts do not represent exsolution and are considered as replacement textures as they formed subsequent to daqingshanite. The origins of the textural relations of the microglobules of daqingshanite to their host Sr-calcite cannot be unambiguously determined, although an exsolution origin is not considered feasible. The textures are similar to those of ‘chalcopyrite disease’ and as such could be interpreted as replacement features formed in a low temperature carbothermal environment which should facilitate replacement. Given that daqingshanite is an early crystallising phase it is also possible that cotectic crystallisation with Sr-calcite occurred, followed by subsolidus re-equilibration with recrystallisation along specific crystallographic planes in the calcite. The Kamthai REE deposit is best described as a low temperature carbothermalite microbreccia consisting of a wide variety of clasts resulting from the autobrecciation of rocks formed during, and after, the magmatic to carbothermal transition of an undetermined parental calcite carbonatite-forming magma. Many clasts have been replaced by late stage La-enriched carbothermal fluids mixed with exogenous water during the final low-temperature stage of evolution of the deposit.
The burden attributable to primary headache disorders in children and adolescents in Ethiopia: estimates from a national schools-based study
Authors: Zewde Yared Zenebe , Zebenigus Mehila , Demissie Hanna , Tekle-Haimanot Redda , Uluduz Derya , Şaşmaz Tayyar , Bozdag Fatma , Steiner Timothy J 
Published: April 2024

Abstract
Background
We previously reported high prevalences of headache disorders among children (6–11 years) and adolescents (12–17 years) in Ethiopia. Here we provide data on headache-attributed burden collected contemporaneously from the same study participants. Part of the global schools-based programme within the Global Campaign against Headache, the study is the first to present such data from sub-Saharan Africa.

Methods
A cross-sectional survey following the generic protocol for the global study was conducted in six schools (urban and rural), in Addis Ababa city and three regions of Ethiopia. The child or adolescent versions of the Headache-Attributed Restriction, Disability, Social Handicap and Impaired Participation (HARDSHIP) structured questionnaires were self-completed under supervision by pupils in class. Headache diagnostic questions were based on ICHD-3 beta but for the inclusion of undifferentiated headache (UdH).

Results
Of 2,349 eligible participants, 2,344 completed the questionnaires (1,011 children [43.1%], 1,333 adolescents [56.9%]; 1,157 males [49.4%], 1,187 females [50.6%]; participating proportion 99.8%). Gender- and age-adjusted 1-year prevalence of headache, reported previously, was 72.8% (migraine: 38.6%; tension-type headache [TTH]: 19.9%; UdH: 12.3%; headache on ≥ 15 days/month (H15+): 1.2%). Mean headache frequency was 2.6 days/4 weeks but, with mean duration of 2.7 h, mean proportion of time with headache was only 1.0% (migraine: 1.4%; TTH: 0.7%; H15+: 9.1%). Mean intensity was 1.8 on a scale of 1–3. Symptomatic medication was consumed on about one third of headache days across headache types. Lost school time reportedly averaged 0.7 days over the preceding 4 weeks, representing 3.5% of school time, but was 2.4 days/4 weeks (12.0%) in the important small minority with H15+. However, actual absences with headache the day before indicated averages overall of 9.7% of school time lost, and 13.3% among those with migraine. Emotional impact and quality-of-life scores reflected other measures of burden, with clear adverse impact gradients (H15 + > migraine > TTH > UdH).

Conclusions
The high prevalence of headache among children and adolescents in Ethiopia, who represent half its population, is associated with substantial burden. Lost school time is probably the most important consequence. Estimates suggest a quite deleterious effect, likely to be reflected in both individual prospects and the prosperity of society.
An AI-based multiphase framework for improving the mechanical ventilation availability in emergency departments during respiratory disease seasons: a case study
Authors: Ortiz-Barrios Miguel , Petrillo Antonella , Arias-Fonseca Sebastián , McClean Sally , de Felice Fabio , Nugent Chris , Uribe-López Sheyla-Ariany 
Published: April 2024

AbstractBackgroundShortages of mechanical ventilation have become a constant problem in Emergency Departments (EDs), thereby affecting the timely deployment of medical interventions that counteract the severe health complications experienced during respiratory disease seasons. It is then necessary to count on agile and robust methodological approaches predicting the expected demand loads to EDs while supporting the timely allocation of ventilators. In this paper, we propose an integration of Artificial Intelligence (AI) and Discrete-event Simulation (DES) to design effective interventions ensuring the high availability of ventilators for patients needing these devices.MethodsFirst, we applied Random Forest (RF) to estimate the mechanical ventilation probability of respiratory-affected patients entering the emergency wards. Second, we introduced the RF predictions into a DES model to diagnose the response of EDs in terms of mechanical ventilator availability. Lately, we pretested two different interventions suggested by decision-makers to address the scarcity of this resource. A case study in a European hospital group was used to validate the proposed methodology.ResultsThe number of patients in the training cohort was 734, while the test group comprised 315. The sensitivity of the AI model was 93.08% (95% confidence interval, [88.46 − 96.26%]), whilst the specificity was 85.45% [77.45 − 91.45%]. On the other hand, the positive and negative predictive values were 91.62% (86.75 − 95.13%) and 87.85% (80.12 − 93.36%). Also, the Receiver Operator Characteristic (ROC) curve plot was 95.00% (89.25 − 100%). Finally, the median waiting time for mechanical ventilation was decreased by 17.48% after implementing a new resource capacity strategy.ConclusionsCombining AI and DES helps healthcare decision-makers to elucidate interventions shortening the waiting times for mechanical ventilators in EDs during respiratory disease epidemics and pandemics.
Acetate ameliorates ovarian mitochondrial dysfunction in letrozole-induced polycystic ovarian syndrome rat model by improving mitofusin-2
Authors: Olaniyi Kehinde S. , Areloegbe Stephanie E. 
Published: April 2024

AbstractAndrogen excess and metabolic abnormality largely contribute to the pathogenesis of polycystic ovarian syndrome (PCOS), which primarily precipitates ovarian dysfunction and infertility in reproductive-age women. Impaired mitochondrial function and epigenetic alteration have been linked to the development of PCOS. However, it is unknown whether acetate would exert a therapeutic effect on ovarian mitochondrial dysfunction in PCOS. Herein, the study hypothesized that acetate reverses ovarian mitochondrial dysfunction in experimental PCOS rat model, possibly through modulation of mitofusin-2 (MFn2). Eight-week-old female Wistar rats were randomized into four groups (n = 5). Induction of PCOS was performed by 1 mg/kg letrozole (p.o.), administered for 21 days. Thereafter, the rats were treated with acetate (200 mg/kg; p.o.) for 6 weeks. The PCOS rats demonstrated androgen excess, multiple ovarian cysts, elevated anti-mullerian hormone and leptin and decreased SHBG, adiponectin and 17-β estradiol with corresponding increase in ovarian transforming growth factor-β1. Additionally, inflammation (tumor growth factor and nuclear factor-kB), elevated caspase-6, decreased hypoxia-inducible factor-1α and elevated histone deacetylase-2 (HDAC2) were observed in the ovaries of PCOS rats, while mitochondrial abnormality with evidence of decreased adenosine triphosphate synthase and MFn2 was observed in rats with PCOS. Treatment with acetate reversed the alterations. The present results collectively suggest that acetate ameliorates ovarian mitochondrial abnormality, a beneficial effect that is accompanied by MFn2 with consequent normalization of reproductive-endocrine profile and ovarian function. Perhaps, the present data provide hope for PCOS individuals that suffer infertility.
Genome-wide identification of tea plant (Camellia sinensis) BAHD acyltransferases reveals their role in response to herbivorous pests
Authors: Qiao Dahe , Yang Chun , Mi Xiaozeng , Tang Mengsha , Liang Sihui , Chen Zhengwu 
Published: April 2024

Abstract
Background
BAHD acyltransferases are among the largest metabolic protein domain families in the genomes of terrestrial plants and play important roles in plant growth and development, aroma formation, and biotic and abiotic stress responses. Little is known about the BAHDs in the tea plant, a cash crop rich in secondary metabolites.

Results
In this study, 112 BAHD genes (CsBAHD01-CsBAHD112) were identified from the tea plant genome, with 85% (98/112) unevenly distributed across the 15 chromosomes. The number of BAHD gene family members has significantly expanded from wild tea plants to the assamica type to the sinensis type. Phylogenetic analysis showed that they could be classified into seven subgroups. Promoter cis-acting element analysis revealed that they contain a large number of light, phytohormones, and stress-responsive elements. Many members displayed tissue-specific expression patterns. CsBAHD05 was expressed at more than 500-fold higher levels in purple tea leaves than in green tea leaves. The genes exhibiting the most significant response to MeJA treatment and feeding by herbivorous pests were primarily concentrated in subgroups 5 and 6. The expression of 23 members of these two subgroups at different time points after feeding by tea green leafhoppers and tea geometrids was examined via qPCR, and the results revealed that the expression of CsBAHD93, CsBAHD94 and CsBAHD95 was significantly induced after the tea plants were subjected to feeding by both pricking and chewing pests. Moreover, based on the transcriptome data for tea plants being fed on by these two pests, a transcriptional regulatory network of different transcription factor genes coexpressed with these 23 members was constructed.

Conclusions
Our study provides new insights into the role of BAHDs in the defense response of tea plants, and will facilitate in-depth studies of the molecular function of BAHDs in resistance to herbivorous pests.
Systemic immune-inflammation index as a novel predictor of major adverse cardiovascular events in patients undergoing percutaneous coronary intervention: a meta-analysis of cohort studies
Authors: Zhang Chunyu , Li Minghao , Liu Lin , Deng Li , Yulei Xie , Zhong Yi , Liao Bin , Yu Lu , Feng Jian 
Published: April 2024

Abstract
Background
The Systemic Immune-Inflammation Index (SII), a novel marker of inflammation based on neutrophil, platelet, and lymphocyte counts, has demonstrated potential prognostic value in patients undergoing percutaneous coronary intervention (PCI). Our aim was to assess the correlation between the SII and major adverse cardiovascular events following percutaneous coronary intervention.

Methods
We searched PubMed, Web of Science, Embase, and The Cochrane Library from inception to November 20, 2023, for cohort studies investigating the association between SII and the occurrence of MACEs after PCI. Statistical analysis was performed using Revman 5.3, with risk ratios (RRs) and 95% confidence intervals (CIs) as relevant parameters.

Results
In our analysis, we incorporated a total of 8 studies involving 11,117 participants. Our findings revealed that a high SII is independently linked to a increased risk of MACEs in PCI patients (RR: 2.08,95%CI: 1.87–2.32, I2 = 42%, p < 0.00001). Additionally, we demonstrated the prognostic value of SII in all-cause mortality, heart failure, and non-fatal myocardial infarction.

Conclusions
Elevated SII may serve as a potential predictor for subsequent occurrence of MACEs in patients undergoing PCI.

Trial registration
Our protocol was registered in PROSPERO (registration number: CRD42024499676).
16S rRNA seq-identified Corynebacterium promotes pyroptosis to aggravate diabetic foot ulcer
Authors: Zheng Hailong , Na Han , Yao Jiangling , Su Sheng , Han Feng , Li Xiaoyan , Chen Xiaopan 
Published: April 2024

AbstractBackgroundDiabetic foot ulcer (DFU) is one of the main chronic complications caused by diabetes, leading to amputation in severe cases. Bacterial infection affects the wound healing in DFU.MethodsDFU patients who met the criteria were selected, and the clinical data were recorded in detail. The pus exudate from the patient’s foot wound and venous blood were collected for biochemical analysis. The distribution of bacterial flora in pus exudates of patients was analyzed by 16S rRNA sequencing, and the correlation between DFU and pathogenic variables, pyroptosis and immunity was analyzed by statistical analysis. Then, the effects of key bacteria on the inflammation, proliferation, apoptosis, and pyroptosis of polymorphonuclear leukocytes were investigated by ELISA, CCK-8, flow cytometry, RT-qPCR and western blot.ResultsClinical data analysis showed that Wagner score was positively correlated with the level of inflammatory factors, and there was high CD3+, CD4+, and low CD8+levels in DFU patients with high Wagner score. Through alpha, beta diversity analysis and species composition analysis, Corynebacterium accounted for a large proportion in DFU. Logistics regression model and Person correlation analysis demonstrated that mixed bacterial infections could aggravate foot ulcer, and the number of bacteria was closely related to inflammatory factors PCT, PRT, immune cells CD8+, and pyroptosis-related proteins GSDMD and NLRP3. Through in vitro experiments, Corynebacterium inhibited cell proliferation, promoted inflammation (TNF-α, PCT, CRP), apoptosis and pyroptosis (IL-1β, LDH, IL-18, GSDMD, NLRP3, and caspase-3).ConclusionMixed bacterial infections exacerbate DFU progression with a high predominance of Corynebacterium, and Corynebacterium promotes inflammation, apoptosis and pyroptosis to inhibit DFU healing.
Acute kidney injury in hospitalized patients with nonmalignant pleural effusions: a retrospective cohort study
Authors: Wang Danni , Niu Yue , Chen Dinghua , Li Chaofan , Liu Fei , Feng Zhe , Cao Xueying , Zhang Li , Cai Guangyan , Chen Xiangmei , Li Ping 
Published: April 2024

Abstract
Background
Nonmalignant pleural effusion (NMPE) is common and remains a definite health care problem. Pleural effusion was supposed to be a risk factor for acute kidney injury (AKI). Incidence of AKI in NMPE patients and whether there is correlation between the size of effusions and AKI is unknown.

Objective
To assess the incidence of AKI in NMPE inpatients and its association with effusion size.

Study design and method
We conducted a retrospective cohort study of inpatients admitted to the Chinese PLA General Hospital with pleural effusion from 2018-2021. All patients with pleural effusions confirmed by chest radiography (CT or X-ray) were included, excluding patients with diagnosis of malignancy, chronic dialysis, end-stage renal disease (ESRD), community-acquired AKI, hospital-acquired AKI before chest radiography, and fewer than two serum creatinine tests during hospitalization. Multivariate logistic regression and LASSO logistic regression models were used to identify risk factors associated with AKI. Subgroup analyses and interaction tests for effusion volume were performed adjusted for the variables selected by LASSO. Causal mediation analysis was used to estimate the mediating effect of heart failure, pneumonia, and eGFR < 60 ml/min/1.73m2 on AKI through effusion volume.

Results
NMPE was present in 7.8% of internal medicine inpatients. Of the 3047 patients included, 360 (11.8%) developed AKI during hospitalization. After adjustment by covariates selected by LASSO, moderate and large effusions increased the risk of AKI compared with small effusions (moderate: OR 1.47, 95%CI 1.11-1.94 p = 0.006; large: OR 1.86, 95%CI 1.05-3.20 p = 0.028). No significant modification effect was observed among age, gender, diabetes, bilateral effusions, and eGFR. Volume of effusions mediated 6.8% (p = 0.005), 4.0% (p = 0.046) and 4.6% (p < 0.001) of the effect of heart failure, pneumonia and low eGFR on the development of AKI respectively.

Conclusion
The incidence of AKI is high among NMPE patients. Moderate and large effusion volume is independently associated with AKI compared to small size. The effusion size acts as a mediator in heart failure, pneumonia, and eGFR.