bluuebunny/crossref_metadata_2025_split huggingface dataset:
TOXICITY TESTING OF CHITOSAN OF PAPUYU FISH SCALE (Anabas testudineus) TOWARD BHK-21 FIBROBLAST CELLS
Authors: Rohmah Siti , Ichrom Nahzi Muhammad Yanuar , Tri Putri Deby Kania 
Published: April 2024

Background: Pulp capping is a treatment that aims to maintain the viability of the pulp tissue. Calcium hydroxide (Ca(OH)2 is a material that is often used for pulp capping procedures. However, this material does not provide a good adaptation to dentin. Therefore, an alternative material that is more biocompatible is needed, one of which is by using papuyu fish scale chitosan. papuyu fish as an alternative material must be proven to have no toxic effects. Purpose: to analyze whether the chitosan of papuyu fish scales (Anabas testudineus) is toxic to BHK-21 fibroblast cells using the MTT assay method. Methods: This study was a pure experimental study with a post-test-only design with a control group design consisting of 12 groups. The group given the chitosan treatment of papuyu fish scales consisted of 10 groups with concentrations of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% and 100% with 2 control groups namely control cells. and media control. Results: The results showed that the chitosan of papuyu fish scales did not have a toxic effect on BHK-21 fibroblast cells because the percentage value of cell viability of the entire treatment group was > 60% and the IC50 value was > 0.1%, which was 5.405 %. Conclusion: There was no toxic effect after administration of papuyu fish scales chitosan (Anabas testudineus) with concentrations of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, and 100% on cells BHK-21 fibroblasts. Keywords: BHK-21 fibroblast cells, Papuyu fish scale chitosan, Toxicity test
COMPARISON OF THE ACCURACY OF MANUAL CEPHALOMETRY RADIOGRAPHIC MEASUREMENTS AND WEB-BASED DIGITAL SOFTWARE
Authors: Puspitasari Yustisia , Oemar Mattalitti Sitti Fadhilah , Novawaty Eva , Roeswahjuni Neny 
Published: April 2024

Background: Determining anatomical landmarks - in the cranium, maxilla and mandible - as well as measuring skeletal and dental angles on cephalometric radiographs are supporting examinations that determine important diagnoses in orthodontic treatment. Traditionally, cephalometric analysis has been performed by tracing radiographic landmarks on acetate overlays and measuring linear and angular variables using protractor. However, despite its widespread use in orthodontics, the technique is time consuming and has several drawbacks, including a high risk of error in tracing, landmark identification, and measurement. Objective: to evaluate the difference of cephalometric measurements using manual and digital technique. Method: pre-treatment cephalometric digital radiographs of 40 patients were traced manually and digitally using WebCeph Ver. 1.0.0 computer software program by the same investigator. A total of 8 anatomical landmarks were located and five angular measurements based on Steiner Analysis were measured. Independent t-tests and Mann-Whitney tests were used to compare the difference of manual and digital measurements. Result: the p-values for SNA, SNB, ANB, I-NA, I-NB were greater than 0.05 (p>0.05). Conclusion: There were no significant difference between manual and digital tracing cephalometric technique using WebCeph for SNA, SNB, ANB, I-NA and I-NB Keywords: Cephalometric measurement, Digital cephalometric analysis, Steiner Analysis, Tracing cephalometry, WebCeph
THE CORRELATION OF OROMOTOR DYSFUNCTION TO ORAL HEALTH-RELATED QUALITY OF LIFE IN CHILDREN WITH DOWN SYNDROME
Authors: Dewi Nurdiana , Kelana Adhytya Suryo , Utami Juliyatin Putri 
Published: April 2024

Background: The genetic condition known as Down syndrome (DS) is brought on by chromosome 21 trisomy. Children with DS frequently have oromotor dysfunctiont. Oromotor dysfunction in children with Down syndrome can lead to oral health issues and lower the oral health-related quality of life. Studies on the relationship between oromotor dysfunction and quality of life related to dental health in children with Down syndrome are still lacking, nevertheless. Objective: To analyze the correlation between oromotor dysfunction and oral health-related quality of life in children with DS. Methods: Total respondents used in this research was 30 children with DS and the parents in Banjarmasin Special Schools. Oromotor dysfunction was determined using the Oral Motor Assessment Scale (OMAS) and oral health-related quality of life was determined using the Modified Parent-Caregiver Perception Questionnaire (P-CPQ). The Spearman correlation test was used to analyze the correlation between oromotor dysfunction and oral health related quality of life in Down syndrome children. Results: The Spearman correlation test showed that there was a significant correlation between oromotor dysfunction and oral health-related quality of life in children with DS with a significance value of 0.000 (p <0.05) with the correlation coefficient of 0.637. Conclusion: There was a positive and strong correlation between oromotor dysfunction and oral health-related quality of life in children with DS. The weaker the oromotor function in children with Down syndrome is, the worse the oral health-related quality of life will be.Keywords: Down syndrome, oral health-related quality of life, oromotor dysfunction.
ANTIBACTERIAL ACTIVITY TEST OF CUCUMBER PEEL EXTRACT (Cucumis sativus L.) AGAINST Streptococcus mutans BACTERIA
Authors: Dewi Rahmalia , Masyhudi Masyhudi , Alhawaris Alhawaris , Yani Sinar , Yadi Yadi 
Published: April 2024

Background: Dental caries is a process of tooth demineralization caused by acids produced from food metabolism in bacteria. One of the main etiological factors of dental caries is the microorganisms known as Streptococcus mutans bacteria. S. mutans is one of the components of human dental plaque that is associated with sucrose diet and high caries activity. Cucumber peel extract (Cucumis sativus L.) is known to have an antibacterial activity due to the presence of secondary metabolites such as flavonoids, steroids, alkaloids, saponins and phenols found in cucumber peel. Purpose: This study aimed to determine the antibacterial activity at the lowest concentration of cucumber peel extract (Cucumis sativus L.) against Streptococcus mutans bacteria. Method: This study employed the disc diffusion method with a post-test only control group design. Streptococcus mutans bacteria were cultured on Mueller Hinton Agar media, and cucumber peel extract (Cucumis sativus L.) was applied as the antibacterial agent at concentrations of 0.01 g/ml, 0.05 g/ml, 0.1 g/ml, 0.2 g/ml, 0.4 g/ml and 0.5 g/ml with seven repetitions. Results: The results of the study showed that cucumber peel extract (Cucumis sativus L.) formed inhibition zones around the paper discs against the growth of Streptococcus mutans bacteria at concentrations of 0.4 g/ml and 0.5 g/ml. Conclusion: The concentrations of 0,4 g/ml and 0,5 g/ml are the lowest concentrations of cucumber peel extract (Cucumis sativus L.) that can inhibit the growth of Streptococcus mutans bacteria. Keywords : Antibacterial, Cucumber peel, Dental Caries, Streptococcus mutans
Drug utilization of N-Acetylcysteine in COVID-19 inpatients at Santa Elisabeth Hospital, Purwokerto
Authors: Ekowati Heny , Nadzif Faradina Qorina , Suryoputri Masita Wulandari 
Published: April 2024

Background: COVID-19 is associated to an oxidant-antioxidant imbalance, which leads to inflammation and tissue damage. N-Acetylcysteine (NAC), in addition to being a mucolytic, has been shown to be an effective antioxidant in the therapy of COVID-19.
Objective: The purpose of this study is to evaluate at the NAC usage profile in COVID-19 inpatients at Santa Elisabeth Hospital in Purwokerto.
Methods: A descriptive observational design was used to perform the study. Retrospective data were obtained from medical records from July 2020 to July 2021. All patients who met the inclusion criteria were sampled using the total sampling technique.
Results: NAC was commonly administered to COVID-19 inpatients who have a mild illness of the disease. The most common symptoms were cough and fever. Patients with mild and moderate severity were given NAC orally (600 mg 3 times a day) and intravenously (5 gram/day), respectively. The duration of NAC administration was in the range of 8-14 days.
Conclusion: NAC was one of the therapies used at Santa Elisabeth Hospital Purwokerto for COVID-19 inpatients.
Optimizing effervescent granules of butterfly pea (Clitoria ternatea L) flower ethanol extract as antioxidant
Authors: Suhesti Tuti Sri , Warsinah Warsinah , Wulandari Pitra 
Published: April 2024

Background: Butterfly pea (Clitoria ternatea) contains secondary metabolites, including flavonoids, saponins, terpenoids, tannins, and anthocyanins which have antioxidant activity.
Objective: This research aims to produce the effervescent granule preparations of the butterfly pea flower ethanol extract with the optimal concentrations of citric acid and tartaric acid.
Methods: Butterfly pea flower was extracted using 70% ethanol. Effervescent granules were made using the wet granulation method in eight formulas containing citric acid and tartaric acid. The physical properties of granules were evaluated, including extract quality, flow rate, dissolution time, and pH.
Results: The concentration of the mixed components of citric acid 48.65 mg and tartaric acid 576.30 mg was the most optimal combination of acid sources for effervescent granules of butterfly pea flower extract with a desirability value of 1,000.
Conclusion: The variation in the concentration of citric acid and tartaric acid affected flow rate, dissolution time, and pH of the effervescent granule preparation.
Authors: Mutiar Sri , Yusmita Lisa , Kasim Anwar 
Published: April 2024

Lead time merupakan salah satu metode yang digunakan untuk menghilangkan aktivitas-aktivitas yang tidak memberikan nilai tambah pada suatu proses produksi. Proses penyamakan kulit pada umumnya merupakan rangkaian proses yang sangat panjang dengan jumlah bahan kimia yang sangat banyak. Proses penyamakan pada umumnya dimulai dari kulit mentah, buang bulu, buang lemah, netralisasi, pikel, penyamakan mineral, penyamakan nabati, penyamakan ulang, dan finisihing. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh waktu penyamakan terhadap karakteristik kulit tersamak yang dihasilkan. Bahan yang digunakan dalam percobaan ini menggunakan kulit kambing. Percobaaan penyamakan kulit dengan berbagai waktu penyamakan 3 jam, 6 jam, 12 jam dan 24 jam. bahan penyamak mimosa, quebraco dan ektrak kulit kayu Acacia mangium melalui penyamakan tunggal. Analisis kualitas kulit tersamak ditentukan dari karakteristik kulit tersamak secara kimia, pengukuran sifat fisik dan organoleptis kulit tersamak. Analisis data menggunakan T test untuk melihat pengaruh perbedaan waktu. Hasil penelitian menunjukkan bahwa untuk menghasilkan kulit kambing tersamak yang memenuhi standar penggunaan waktu penyamakan ≥ 12 jam.
Relationship of Problematic Internet Use, Fear of Missing Out, Loneliness and Nomophobia among Filipino Nursing Students
Authors: Hoseña Megumi Ayagail , Mallorca Pamela Remle Irish , Muyot Yvanna Monique , Tan Iris Nicole , Calong Calong Kathyrine , Soriano Gil P 
Published: April 2024

The dominance of technology use has brought growing concerns regarding its influence on human living phenomena such as problematic Internet use, fear of missing out, and nomophobia. Hence, the study aimed to determine the relationship between problematic use of the Internet, fear of missing out, loneliness, and nomophobia among nursing students. A descriptive-correlational research design was conducted with 117 nursing students selected through purposive sampling. Data were collected using an online questionnaire consisting of the Generalized Problematic Internet Use Scale 2, Fear of Missing Out Scale, Nomophobia Questionnaire, and the UCLA Loneliness Scale. Data were analyzed using frequency distribution and percentages, means, standard deviations, and Pearson’s r correlation. Results showed that problematic internet use significantly correlated with fear of missing out (r=0.223, p=0.015) and loneliness (r=0.289, p=0.002). In contrast, fear of missing out was revealed to have a significant negative relationship with nomophobia (r= -0.233, p=0.011). Despite the rise in digital activities among distance learning nursing students, loneliness and fear of missing out scores are low. However, higher nomophobia scores and strong relationships between concepts necessitate being alert to potential issues, keeping an eye on things, and adopting safety measures.
Translation, Adaptation, and Psychometric Validation of the Indonesia Version of Job Diagnostic Survey: Hospital Nurse Setting
Authors: Aungsuroch Yupin , Fisher Mary L. , Juanamasta I Gede , Wati Ni Made Nopita , Lestari R. Tri Rahyuning 
Published: April 2024

A job diagnostic survey is used to measure work or job characteristics. However, there is limited study exploring the psychometric properties of the Indonesian version. This study aimed to validate the Indonesian version of the Hack and Oldham Job Diagnostic Survey.
Cronbach's alpha coefficient value showed a significant value for all evaluated dimensions. As for concurrent validity, a significant correlation was discovered between all dimensions. Construct validity for job characteristics, experienced psychological states, and affective responses to the job were significant. Cronbach's alpha coefficient value was ≥0.825 for all evaluated dimensions. As for concurrent validity, a significant correlation was found between all dimensions (r = 0.357- 0.752). Construct validity for job characteristics, experienced psychological states, and affective responses to the job were significant (χ2 = 0.00, CFI = 0.99, GFI = 0.91, RMSEA = 0.06 and SRMSR = 0.05). The Job Diagnostic Survey Indonesian version (JDS-I) has been validated, exhibits good psychometric properties, and retains the original features of the instrument.
Approximate Solution to the Schrödinger Equation of Exotic Doubly Muonic Helium-like Systems Using Hydrogenic-based Matrix Mechanics
Authors: Pingak Redi Kristian , Jacob Johanes Eliaser , Bernandus Bernandus , Johannes Albert Zicko , Setiawan Ely 
Published: April 2024

The approximate solution to the Schrödinger equation of exotic doubly muonic helium-like systems has been obtained using a simple matrix method based on hydrogenic s-states. Each system considered consists of a positively charged nucleus surrounded by 2 negatively charged muons XZ+μ-μ- (2 Z 36). The present work aims to obtain approximate ground-state energies of the systems and to decompose the energies in terms of the basis states used. Here, the wave function was expressed as a linear combination of 15 eigenfunctions, each written as the product of two hydrogenic s-states. The elements of the Hamiltonian matrix were calculated and finally, the energy eigenvalue equation was numerically solved to obtain the ground-state energies of the systems with their corresponding eigenvectors. From the results, ground-state energies of all systems were in agreement with others from the literature, with percentage differences between 0.03% and 2.05%. The analysis of the probability amplitudes from the eigenvectors showed that the 1s1s state made the largest contribution to the ground state energies of the systems, approaching 90.99%, 96.98% and 98.54% for He2+μ-μ- , Li3+μ-μ- , and Be4+μ-μ- , respectively.

Keywords: Doubly muonic helium-like systems, ground state energy, hydrogenic basis states, matrix mechanics, Schrödinger equation
Bioactivity of Papua Red Fruit Extract (Pandanus conoideus L.) Against Superoxide dismutase, Malondialdehyde and Blood Glucose of Rat (Rattus norvegicus L.) Hyperglycemia
Authors: Mokosuli Yermia Semuel , Migau Natalina , Wurarah Masje 
Published: April 2024

Red fruit (Pandanus conodus L.) is a plant native to Papua, ethnomedical used as a traditional medicine with a wide spectrum of pharmacological effects. However, research on the bioactivity of red fruit is still very poorly reported. The aim of this study was to characterize the bioactive content, antioxidant bioactivity and the effect of lowering blood glucose in hyperglycemic rats. Red fruit has extracted used the maceration method with 95% ethanol. Analysis of active compound content using Gas Chromatography Mass Spectrophotometry (GC MS). Analysis of Malondialdehyde (MDA), Superoxide dismutase (SOD) and blood glucose levels was carried out using the in vivo method using white rats. The research results showed that red fruit ethanol extract contained 173 compounds from six main groups of compounds. Red fruit extract has effective in reducing MDA levels in hyperglycemic mice. K4 and K5 treatments were the best treatments for reducing MDA. Red fruit extract affects the duration of induction of increased SOD in hyperglycemic rats. Treatments K4 and K5 were the best treatments for SOD induction. Red fruit extract affects reducing blood glucose in hyperglycemic mice. Red fruit extract has antioxidant activity and lowers blood glucose. Red fruit extract has the potential to be developed as a source of bioactive antioxidants and antidiabetics.

Keywords: Glucose, hyperglycemia, malondialdehyde, superoxide dismutase
The Sesquiterpenoids from the Stem Bark of Dysoxylum excelsum and Their Cytotoxic Activities against HeLa Cancer Cell Lines
Authors: Supratman Unang , Kautsari Arsi , Naini Al Arofatus , Riyadi Sandra Amalia , Mayanti Tri , Harizon Harizon , Fajriah Sofa 
Published: April 2024

Sesquiterpenoids belong to a group of terpenoid compounds with interesting structures that are abundant in natural products especially in higher plants. Sesquiterpenoids have a wide variety of bioactivities with great potential cytotoxic activity. The species Dysoxylum excelsum belongs to the Meliaceae family known as higher plant, but only a few sesquiterpenoids have been reported particularly for their cytotoxic activity. Therefore, this research aims to isolate and elucidate the sesquiterpenoids structure from D. excelsum stem bark and examines their cytotoxicity against HeLa cervical cancer cells. Through various column chromatography separations, four known sesquiterpenes namely β-caryophyllene oxide (1), caryophyllenol II (2), humulene dioxide A (3), and guai-6-en-10β-ol (4) were acquired from the n-hexane extract. Compounds 1-4 were isolated for the first time from D. excelsum species. The sesquiterpenoid structures were elucidated according to Nuclear Magnetic Resonance, Infrared, and HR-TOF-MS analysis. The cytotoxicity compounds 1-4 was determined against HeLa cervical cancer cells by examination with the PrestoBlue method and compound 3 exhibited the most potent cytotoxicity with an IC50 value of 160.74 µM.

Keywords: cytotoxic activity, Dysoxylum excelsum, HeLa, Meliaceae, sesquiterpenoid.
Effectiveness of different treatment regimens of enhanced external counterpulsation in patients with stable coronary artery disease complicated by heart failure
Authors: Lishuta A. S. , Slepova O. A. , Nikolaeva N. A. , Khabarova N. V. , Privalova E. V. , Belenkov Yu. N. 
Published: April 2024

Aim. To study the effect of various therapy regimens with enhanced external counterpulsation (EECP) on exercise tolerance, quality of life, indices of structural and functional state of cardiovascular system in patients with stable coronary artery disease (CAD) complicated by chronic heart failure (CHF).Material and methods. The study included patients with stable CAD complicated by CHF with reduced and intermediate left ventricular ejection fraction (LVEF) from the randomized EXCEL trial (NCT05913778; n=120) and additionally patients with similar inclusion and exclusion criteria (n=90) who were randomized into groups with different EECP treatment regimens for 12 months: Group 1 (n=40): course of 35 hour-long procedures; Group 2 (n=40): course of 35 hourlong procedures every 6 months; Group 3 (n=30): course of 20 hour-long procedures then constantly 1 hour per week; Group 4 (n=30): constantly 2 hours per week; Group 5 (n=30): course of 20 hour-long procedures then constantly 2 hours per week; Group 0 (placebo ; n=40): course of 35 hour-long procedures with compression pressure 80 mm Hg. All patients at baseline and after 12 months were assessed for clinical status, quality of life (MLHFQ, SF-36), NT-proBNP levels, LVEF, as well as exercise tolerance (6-minute walk test; 6MWT) initially, after 3, 6, 9 and 12 months. Correlation analysis and risk assessment of adverse events (combined endpoint — combination of cases of adverse cardiovascular events, deaths, hospitalizations for CHF, new-onset of atrial fibrillation, diabetes, decreased renal function) was performed.Results. Treatment effectiveness had positive correlation with EECP duration (r(S)=0,670; p<0,001) and treatment regimen (r(S)=0,620; p<0,001). The maximum effect (changes in NT-proBNP levels, LVEF, clinical status, quality of life) was noted in the combined and constant regimen groups (5, 4, 2). The increase of 6WMTdistance was 6,6% in group 0, 24,9% in group 1, 44,5% in group 2, 31,8% in group 3, 49,1% in group 4, 58,6% in group 5. The proportion of patients with an increase in 6WMT-distance >20% after 12 months was 7,7%, 72,5%, 97,5%, 76,7%, 90%, 100%, respectively. Cumulative event-free survival was highest in groups 5, 4, and 2 (0,97, 0,93, and 0,86, respectively), and the risk of developing combined endpoint in these groups was minimal (0,035, 0,075, and 0,150, respectively).Conclusion. The effect of EECP treatment in patients with coronary artery disease complicated by CHF depended on the EECP hours and regimen. Alternative EECP regimens (with more treatments spread evenly over the year) in addition to optimal medical therapy may improve the management of these patients.