bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimized Lithium Ion Coordination via Chlorine Substitution to Enhance Ionic Conductivity of Garnet‐Based Solid Electrolytes
Authors: Wang Shuhan , Zeng Ting , Wen Xiaojuan , Xu Haoyang , Fan Fengxia , Wang Xinxiang , Tian Guilei , Liu Sheng , Liu Pengfei , Wang Chuan , Zeng Chenrui , Shu Chaozhu 
Published: March 2024

AbstractGarnet‐type solid‐state electrolytes attract abundant attentions due to the broad electrochemical window and remarkable thermal stability while their poor ionic conductivity obstructs their widespread application in all‐solid‐state batteries. Herein, the enhanced ionic conductivity of garnet‐type solid electrolytes is achieved by partially substituting O2− sites with Cl− anions, which effectively reduce Li+ migration barriers while preserving the highly conductive cubic phase of garnet‐type solid‐state electrolytes. This substitution not only weakens the anchoring effect of anions on Li+ to widen the size of Li+ diffusion channel but also optimizes the occupancy of Li+ at different sites, resulting in a substantial reduction of the Li+ migration barrier and a notable improvement in ionic conductivity. Leveraging these advantageous properties, the developed Li6.35La3Zr1.4Ta0.6O11.85‐Cl0.15 (LLZTO‐0.15Cl) electrolyte demonstrates high Li+ conductivity of 4.21×10−6 S cm−1. When integrated with LiFePO4 (LFP) cathode and metallic lithium anode, the LLZTO‐0.15Cl electrolyte enables the solid‐state battery to operate for more than 100 cycles with a high capacity retention of 76.61% and superior Coulombic efficiency of 99.48%. This work shows a new strategy for modulating anionic framework to enhance the conductivity of garnet‐type solid‐state electrolytes.
Amino‐Acid‐Encoded Bioinspired Supramolecular Self‐Assembly of Multimorphological Nanocarriers
Authors: Huang Yifan , Yang Guokun , Yu Zian , Tong Tong , Huang Yan , Zhang Qianzijing , Hong Yajian , Jiang Jun , Zhang Guozhen , Yuan Yue 
Published: March 2024

AbstractSupramolecular self‐assembly has emerged as an efficient tool to construct well‐organized nanostructures for biomedical applications by small organic molecules. However, the physicochemical properties of self‐assembled nanoarchitectures are greatly influenced by their morphologies, mechanical properties, and working mechanisms, making it challenging to design and screen ideal building blocks. Herein, using a biocompatible firefly‐sourced click reaction between the cyano group of 2‐cyano‐benzothiazole (CBT) and the 1,2‐aminothiol group of cysteine (Cys), an amino‐acid‐encoded supramolecular self‐assembly platform Cys(SEt)‐X‐CBT (X represents any amino acid) is developed to incorporate both covalent and noncovalent interactions for building diverse morphologies of nanostructures with bioinspired response mechanism, providing a convenient and rapid strategy to construct site‐specific nanocarriers for drug delivery, cell imaging, and enzyme encapsulation. Additionally, it is worth noting that the biodegradation of Cys(SEt)‐X‐CBT generated nanocarriers can be easily tracked via bioluminescence imaging. By caging either the thiol or amino groups in Cys with other stimulus‐responsive sites and modifying X with probes or drugs, a variety of multi‐morphological and multifunctional nanomedicines can be readily prepared for a wide range of biomedical applications.
High‐Sensitivity Photoelectrochemical Ultraviolet Photodetector with Stable pH‐Universal Adaptability Based on Whole Single‐Crystal Integrated Self‐Supporting 4H‐SiC Nanoarrays
Authors: Wang Hulin , Li Weijun , Gloginjić Marko , Petrović Srdjan , Krupska Tetyana V. , Turov Vladimir V. , Zhao Jialong , Yang Weiyou , Du Zhentao , Chen Shanliang 
Published: March 2024

AbstractEmerging photoelectrochemical (PEC) photodetectors (PDs) have notable advantages over conventional PDs and have attracted extensive attention. However, harsh liquid environments, such as those with high corrosivity and attenuation, substantially restrict their widespread application. Moreover, most PEC PDs are constructed by assembling numerous nanostructures on current collector substrates, which inevitably contain abundant interfaces and defects, thus greatly weakening the properties of PDs. To address these challenges, a high‐performance pH‐universal PEC ultraviolet (UV) PD based on a whole single‐crystal integrated self‐supporting 4H‐SiC nanopore array photoelectrode is constructed, which is fabricated using a two‐step anodic oxidation approach. The PD exhibits excellent photodetection behavior, with high responsivity (218.77 mA W−1), detectivity (6.64 × 1013 Jones), external quantum efficiency (72.47%), and rapid rise/decay times (17/48 ms) under 375 nm light illumination with a low intensity of 0.15 mW cm−2 and a bias voltage of 0.6 V, which is fall in the state‐of‐the‐art of the wide‐bandgap semiconductor‐based PDs reported thus far. Furthermore, the SiC PEC PD exhibits excellent photoresponse and long‐term operational stability in pH‐universal liquid environments. The improved photodetection performance of the SiC PEC PD is primarily attributed to the synergistic effect of the nanopore array structure, integrated self‐supporting configuration, and single‐crystal structure of the whole photoelectrode.
Anti‐pollutant effect of oleic acid against urban particulate matter is mediated via regulation of AhR‐ and TRPV1‐mediated signaling in vitro
Authors: Choi Seoyoung , Yang Seyoung , Kim Ji Woong , Kwon Kitae , Oh Sae Woong , Yu Eunbi , Han Su Bin , Kang Soo Hyun , Lee Jung Hyun , Ha Heejun , Yoo Jeong Kyun , Kim Su Young , Kim Young Soo , Cho Jae Youl , Lee Jongsung 
Published: March 2024

AbstractUrban Particulate Matter (UPM) induces skin aging and inflammatory responses by regulating skin cells through the transient receptor potential vanilloid 1 (TRPV1). Although oleic acid, an unsaturated free fatty acid (FFA), has some functional activities, its effect on UPM‐induced skin damage has not been elucidated. Here, we investigated signaling pathways on how oleic acid is involved in attenuating UPM induced cell damage. UPM treatment increased XRE‐promoter luciferase activity and increased translocation of AhR to the nucleus, resulting in the upregulation of CYP1A1 gene. However, oleic acid treatment attenuated the UPM effects on AhR signaling. Furthermore, while UPM induced activation of TRPV1 and MAPKs signaling which activated the downstream molecules NFκB and AP‐1, these effects were reduced by cotreatment with oleic acid. UPM‐dependent generation of reactive oxygen species (ROS) and reduction of cellular proliferation were also attenuated by the treatment of oleic acid. These data reveal that cell damage induced by UPM treatment occurs through AhR signaling and TRPV1 activation which in turn activates ERK and JNK, ultimately inducing NFκB and AP‐1 activation. These effects were reduced by the cotreatment of oleic acid on HaCaT cells. These suggest that oleic acid reduces UPM‐induced cell damage through inhibiting both the AhR signaling and activation of TRPV1 and its downstream molecules, leading to a reduction of pro‐inflammatory cytokine and recovery of cell proliferation.
Emergent teaching movements in leadership development: Group relations, case‐in‐point, and intentional emergence
Authors: Weng John , Werner Linnette , Steffensmeier Tim 
Published: March 2024

AbstractIn a post‐pandemic context, the need for leadership students to navigate ambiguous conditions and examine their automatic responses to authority has increased. Yet, common approaches to teaching leadership, such as group discussions and simulations, overlook the potential for using development spaces as living laboratories. This article explores three emergent‐based pedagogies (group relations, case‐in‐point, and intentional emergence) that de‐center the instructor, prioritize co‐creation and emergence, and provide living laboratories for students to examine their assumptions and default behaviors related to leadership.
The classroom as laboratory: A theoretical grounding of the intentional emergence framework for leadership development
Authors: Werner Linnette , Fink Alexander 
Published: March 2024

AbstractLeadership development, like other professional areas such as medicine, teaching, and law, requires students to become as adept at practicing leadership as they are at understanding the theory behind it. For example, K‐12 teachers have student teaching, medical students have residencies, cadavers, and virtual reality‐but where is the learning laboratory for leadership? The intentional emergence (IE) pedagogy provides a framework for instructors and learners that both honors the role of the instructor as a goal/outcome‐setter while also embracing the complexities of the leadership development space as a living laboratory and practice field for leadership. Additionally, IE attempts to bring unconscious and default behaviors to the foreground so that critical components of leadership development such as power, privilege, and identities can be seen and included.
A Microcosm of the outside world: Intentional emergence around current events, factions, and polarization
Authors: Hellstrom David , Steiner Jenny P. 
Published: March 2024

AbstractTeaching leadership in today's world requires a combination of introducing theory and best practices, as well as allowing moments that are happening in real‐time, both current events and interactions from the “laboratory” of the classroom, to affect the teaching agenda. Instructors can lean into the model of Intentional Emergence (IE) to help guide them toward welcoming these “real‐life moment” as vital parts of the curriculum. The authors review inside events, outside events, and Temporary Authority Skills Challenges (or TASCs) as examples of IE pedagogy.
Attending to the complexities of leadership learning and practice: Emergent‐based assessment and evaluation strategies
Authors: Soria Krista M. , Kliewer Brandon W. 
Published: March 2024

AbstractIn emergence‐based leadership education, the knowledge and experiences co‐created in the classroom may violate some of the assumptions behind traditional teaching and learning assessment methods. Thus, traditional assessment, evaluation, and outcomes for courses utilizing emergence‐based methods, such as intentional emergence, case‐in‐point, dialogic group process consultations, and group relations/dynamics, are counterintuitive and must be reconsidered. We provide recommendations regarding how to conduct assessment when utilizing emergence‐based teaching methods in leadership education. We review the use of inductive forms of assessment and provide recommendations for broadening learning outcomes and engaging in learning outcomes beyond the knowledge domain.
PRMT5-mediated homologous recombination repair is essential to maintain genomic integrity of neural progenitor cells
Authors: Wang Ya-Jun , Cao Jian-Bo , Yang Jing , Liu Tong , Yu Hua-Li , He Zi-Xuan , Bao Shi-Lai , He Xiao-Xiao , Zhu Xiao-Juan 
Published: March 2024

AbstractMaintaining genomic stability is a prerequisite for proliferating NPCs to ensure genetic fidelity. Though histone arginine methylation has been shown to play important roles in safeguarding genomic stability, the underlying mechanism during brain development is not fully understood. Protein arginine N-methyltransferase 5 (PRMT5) is a type II protein arginine methyltransferase that plays a role in transcriptional regulation. Here, we identify PRMT5 as a key regulator of DNA repair in response to double-strand breaks (DSBs) during NPC proliferation. Prmt5F/F; Emx1-Cre (cKO-Emx1) mice show a distinctive microcephaly phenotype, with partial loss of the dorsal medial cerebral cortex and complete loss of the corpus callosum and hippocampus. This phenotype is resulted from DSBs accumulation in the medial dorsal cortex followed by cell apoptosis. Both RNA sequencing and in vitro DNA repair analyses reveal that PRMT5 is required for DNA homologous recombination (HR) repair. PRMT5 specifically catalyzes H3R2me2s in proliferating NPCs in the developing mouse brain to enhance HR-related gene expression during DNA repair. Finally, overexpression of BRCA1 significantly rescues DSBs accumulation and cell apoptosis in PRMT5-deficient NSCs. Taken together, our results show that PRMT5 maintains genomic stability by regulating histone arginine methylation in proliferating NPCs.
MR Imaging Characteristics of Solitary Fibrous Tumors of the Orbit
Authors: Ziegenfuß Christoph , van Landeghem Natalie , Meier Chiara , Pförtner Roman , Eckstein Anja , Dammann Philipp , Haubold Patrizia , Haubold Johannes , Forsting Michael , Deuschl Cornelius , Wanke Isabel , Li Yan 
Published: March 2024

Abstract
Purpose
Solitary fibrous tumor (SFT) of the orbit is a rare tumor that was first described in 1994. We aimed to investigate its imaging characteristics that may facilitate the differential diagnosis between SFT and other types of orbital tumors.

Material and Methods
Magnetic resonance imaging (MRI) data of patients with immunohistochemically confirmed orbital SFT from 2002 to 2022 at a tertiary care center were retrospectively analyzed. Tumor location, size, morphological characteristics, and contrast enhancement features were evaluated.

Results
Of the 18 eligible patients 10 were female (56%) with a mean age of 52 years. Most of the SFTs were oval-shaped (67%) with a sharp margin (83%). The most frequent locations were the laterocranial quadrant (44%), the extraconal space (67%) and the dorsal half of the orbit (67%). A flow void phenomenon was observed in nearly all cases (94%). On the T1-weighted imaging, tumor signal intensity (SI) was significantly lower than that of the retrobulbar fat and appeared predominantly equivalent (82%) to the temporomesial brain cortex, while on T2-weighted imaging its SI remained equivalent (50%) or slightly hyperintense to that of brain cortex. More than half of the lesions showed a homogeneous contrast enhancement pattern with a median SI increase of 2.2-fold compared to baseline precontrast imaging.

Conclusion
The SFT represents a rare orbital tumor with several characteristic imaging features. It was mostly oval-shaped with a sharp margin and frequently localized in the extraconal space and dorsal half of the orbit. Flow voids indicating hypervascularization were the most common findings.
Angst und Depression bei Jugendlichen
Authors: Resch Franz , Parzer Peter 
Published: March 2024

ZusammenfassungÄngste und Depressionen bei Jugendlichen haben schon in den Jahren vor der COVID-19-Pandemie zugenommen und dann im Pandemiegeschehen noch einmal eine deutliche Steigerung erfahren. In diesem Artikel werden die unterschiedlichen klinischen Ausdrucksformen dieser emotionalen Syndrome detailliert dargestellt und auch die Entwicklungswege einer Kombination beider Störungen expliziert. Auch subklinische Formen von Angst und Depression haben schon deutliche klinische Auswirkungen und beeinträchtigen die Entwicklungsaufgaben der Adoleszenz. Die „avolitionale Depression“ (Depression mit schweren Antriebsstörungen) wird als Sonderform erwähnt. Pathogenetische Bausteine – von einer genetischen Vulnerabilität bis zu psychosozialen Belastungsfaktoren – kommen im Licht der Tatsache zur Diskussion, dass Ängste und Depressionen beim weiblichen Geschlecht im Jugendalter etwa doppelt so häufig auftreten wie beim männlichen. Die Einbettung der Störungen in das aktuelle Zeitgeschehen zeigt die besondere Bedeutung der selbstreflexiven Emotion „Scham“ im jugendlichen Entwicklungsprozess. Vor einer Verknappung und Dysfunktionalität des emotionalen Dialogs zwischen wichtigen Bezugspersonen und Kindern muss gewarnt werden. Dessen Rolle für die Selbst- und Affektregulation der Jugendlichen ist nicht zu unterschätzen. Den Abschluss bildet eine Übersicht über die wichtigsten therapeutischen Maßnahmen bei Ängsten und Depressionen im Jugendalter.
A novel numerical modeling of microsecond laser beam percussion micro-drilling of Hastelloy X: experimental validation and multi-objective optimization
Authors: Aghaei Attar Milad , Razmkhah Omid , Ghoreishi Majid , Moradi Mahmoud 
Published: March 2024

AbstractThe paper investigates the characteristics of the laser beam percussion micro-drilling (LBPMD) process in aerospace nickel-based superalloy Hastelloy X using microsecond pulses. The quality of the drilled hole is crucial in laser beam micromachining, and selecting appropriate process parameters significantly impacts the hole’s quality. The objective is to achieve predefined hole dimensions with minimal taper angles. Additionally, the study focuses on the alteration of pulse width, which is a combination of laser pulse frequency and duty cycle. Laser power (P), duty cycle % (D), focal plane position (FPP), and laser frequency (f) are considered input parameters, while geometric features such as inlet and outlet diameters, hole taper angle, and inlet circularity are examined as process responses. ANOVA is employed to establish significant relationships between process parameters and response variations based on experimental tests. Creating a precise simulation model that accurately accounts for the moving boundary of the target material’s receding surface is a crucial and challenging task in formulating the laser heat conduction problem. It is necessary to simultaneously capture the material’s dynamic front movement and update the boundary conditions of the laser source. To model the micro-drilled hole with LBPMD, the UMESHMOTION and DFLUX subroutines, along with the arbitrary Lagrangian-Eulerian (ALE) adaptive remesh algorithm in the Abaqus™ software, are utilized. Notably, no previous numerical study has predicted the geometry of micro-drilled holes using this technique. The proposed procedure is validated through the predictions of inlet and outlet hole diameters. Special emphasis is placed on the validation of models. Consequently, the numerical model and statistical model are compared as well as the need to define model applicability. The study demonstrates that all input parameters significantly influence the inlet hole diameter, while the pulse width notably affects the taper angle and circularity. The interaction between high laser frequency and low duty cycle results in reduced pulse duration. Multi-objective optimization is performed to determine the optimal process parameter settings for desired quality characteristics, considering minimum hole taper angle, precise inlet diameter, and maximum inlet circularity of the hole as optimization criteria. The findings show that with the optimized predicted results obtained from the optimal input variables, a composite desirability of 92% can be achieved.
Single-dose Tadalafil Reduces Opening Urethral Pressure: A Randomized, Double-blind, Placebo-controlled, Crossover Trial in Healthy Women
Authors: Christoffersen Thea , Riis Troels , Sonne David P. , Klarskov Niels 
Published: March 2024

Abstract
Introduction and Hypothesis
Phosphodiesterase enzymes are widely distributed in female urogenital tissues. Yet, the understanding of their physiological roles and the impact of phosphodiesterase inhibitors on lower urinary tract symptoms in women remains limited. Current hypotheses are conflicting: one suggests that vasodilation might expand the periurethral vascular plexus, leading to increased urethral pressure, whereas the other proposes a relaxation of urethral musculature, resulting in decreased pressure. To further clarify this, we investigated the effect of tadalafil on the opening urethral pressure and voiding function in healthy women.

Methods
We conducted a randomized, double-blind, placebo-controlled crossover trial involving 24 healthy women. Participants were randomly assigned to receive a single dose of tadalafil (40 mg) or placebo during their initial visit and then switched to the alternative treatment during their second visit. Opening urethral pressure was measured with urethral pressure reflectometry during both resting and squeezing conditions of the pelvic floor. Subsequently, voiding parameters were recorded.

Results
Compared with placebo, a single dose of tadalafil significantly reduced opening urethral pressure during both resting (-6.8 cmH20; 95% confidence interval [CI], -11.8 to -1.9; p = 0.009) and squeezing conditions (-8.8 cmH20; 95% CI, -14.6 to -3.1; p = 0.005). Voiding parameters did not show significant differences (average flow rate: -0.8 ml/s [95% CI, -2.0 to 0.4; p = 0.2]; maximum flow rate: -1.7 ml/s [95% CI, -4.8 to 1.5; p = 0.3]).

Conclusions
A single dose of 40 mg tadalafil moderately reduced urethral pressure in healthy women, without affecting voiding parameters. The clinical implications of this are yet to be determined.
Validation of a Stenotrophomonas maltophilia bloodstream infection prediction score in the hematologic malignancy population
Authors: Gill Emily L. , Gill Christian M. , McEvoy Colleen 
Published: March 2024

AbstractStenotrophomonas maltophilia (SM) bloodstream infections (BSIs) contribute to significant mortality in hematologic malignancy (HM) and hematopoietic stem cell transplantation (HSCT) patients. A risk score to predict SM BSI could reduce time to appropriate antimicrobial therapy (TTAT) and improve patient outcomes. A single center cohort study of hospitalized adults with HM/HSCT was conducted. Patients had ≥ 1 blood culture with a Gram-negative (GN) organism. A StenoSCORE was calculated for each patient. The StenoSCORE2 was developed using risk factors for SM BSI identified via logistic regression. Receiver operating characteristic (ROC) curves were plotted. Sensitivity and specificity for the StenoSCORE and StenoSCORE2 were calculated. Thirty-six SM patients and 534 non-SM patients were assessed. A StenoSCORE ≥ 33 points was 80% sensitive, 68% specific, and accurately classified 69% of GN BSIs. StenoSCORE2 variables included acute leukemia, prolonged neutropenia, mucositis, ICU admission, recent meropenem and/or cefepime exposure. The StenoSCORE2 performed better than the StenoSCORE (ROC AUC 0.84 vs. 0.77). A StenoSCORE2 ≥ 4 points was 86% sensitive, 76% specific, and accurately classified 77% of GN BSIs. TTAT was significantly longer for patients with SM BSI compared with non-SM BSI (45.16 h vs. 0.57 h; p < 0.0001). In-hospital and 28-day mortality were significantly higher for patients with SM BSI compared to non-SM BSI (58.3% vs. 18.5% and 66.7% vs. 26.4%; p-value < 0.0001). The StenoSCORE and StenoSCORE2 performed well in predicting SM BSIs in patients with HM/HSCT and GN BSI. Clinical studies evaluating whether StenoSCORE and/or StenoSCORE2 implementation improves TTAT and clinical outcomes are warranted.
Leaving trusted paths: Estimating corneal keratometric index in cataract surgery eyes with zero-power implants
Authors: Gatinel Damien , Hoffmann Peter C. , Cooke David L. , Chingan Alexandre , Debellemanière Guillaume , Langenbucher Achim , Wendelstein Jascha A. 
Published: March 2024

Abstract
Purpose
This study aimed to estimate the corneal keratometric index in the eyes of cataract surgery patients who received zero-power intraocular lenses (IOLs).

Methodology
This retrospective study analyzed postoperative equivalent spherical refraction and axial length, mean anterior curvature radius and aqueous humor refractive index to calculate the theoretical corneal keratometric index value (nk). Data was collected from 2 centers located in France and Germany.

Results
Thirty-six eyes were analyzed. The results revealed a mean corneal keratometric index of 1.329 ± 0.005 for traditional axial length (AL) and 1.331 ± 0.005 for Cooke modified axial length (CMAL). Results ranged from minimum values of 1.318/1.320 to maximum values of 1.340/1.340.

Conclusion
The corneal keratometric index is a crucial parameter for ophthalmic procedures and calculations, particularly for IOL power calculation. Notably, the estimated corneal keratometric index value of 1.329/1.331 in this study is lower than the commonly used 1.3375 index. These findings align with recent research demonstrating that the theoretical corneal keratometric index should be approximately 1.329 using traditional AL and 1.331 using CMAL, based on the ratio between the mean anterior and posterior corneal curvature radii (1.22).