bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brittle Deformation of Damaged Mafic and Ultramafic Rocks and Their Implications on Plate Bending
Authors: Jayawickrama Eranga , Akamatsu Yuya , Katayama Ikuo 
Published: April 2024

AbstractThe effect of damage on the brittle deformation of mafic and ultramafic rocks has been investigated by performing triaxial deformation experiments on thermally cracked and intact rock samples. The investigation was performed by recording the axial and lateral strains during deformation while simultaneously capturing the ultrasonic velocity, and electrical resistivity. While the peak strength is presumably controlled by the stiff intrinsic fractures, the crack opening mode also showed critical effects on the attained peak strength. The pore pressure distribution showed an apparent control over the dynamic Young's modulus as the ratio between the dynamic and static modulus of thermally cracked rocks is significantly higher than that of intact rocks. The compliant nature and the higher inelastic volumetric strain of the thermally cracked samples further indicated a possible explanation to the steep dipping plates and the taller topographic heights at the trench outer rise systems of old subduction zones.
Introduction to the Distributional Finite Difference Method for 3D Seismic Wave Propagation and Comparison With the Spectral Element Method
Authors: Lyu Chao , Masson Yder , Romanowicz Barbara , Zhao Liang 
Published: April 2024

AbstractWe have extended the distributional finite difference method (DFDM) to simulate the seismic‐wave propagation in 3D regional earth models. DFDM shares similarities to the discontinuous finite element method on a global scale and to the finite difference method locally. Instead of using linear staggered finite‐difference operators, we employ DFDM operators based on B‐splines and a definition of derivatives in the sense of distributions, to obtain accurate spatial derivatives. The weighted residuals method used in DFDM's locally weak formalism of spatial derivatives accurately and naturally accounts for the free surface, curvilinear meshing, and solid‐fluid coupling, for which it only requires setting the shear modulus and the continuity condition to zero. The computational efficiency of DFDM is comparable to the spectral element method (SEM) due to the more accurate mass matrix and a new band‐diagonal mass factorization. Numerical examples show that the superior accuracy of the band‐diagonal mass and stiffness matrices in DFDM enables fewer points per wavelength, approaching the spectral limit, and compensates for the increased computational burden due to four Lebedev staggered grids. Specifically, DFDM needs 2.5 points per wavelength, compared to the five points per wavelength required in SEM for 0.5% waveform error in a homogeneous model. Notably, while maintaining the same accuracy in the solid domain, DFDM demonstrates superior accuracy in the fluid domain compared to SEM. To validate its accuracy and flexibility, we present various 3D benchmarks involving homogeneous and heterogeneous regional elastic models and solid‐fluid coupling in both Cartesian and spherical settings.
Characterizing Precipitation Behaviors of H− in the Martian Atmosphere
Authors: Henderson Sarah , Halekas Jasper , Jolitz Rebecca , Mitchell David , Mazelle Christian , Eparvier Frank , Elrod Meredith 
Published: April 2024

AbstractSolar wind protons can charge exchange with the extensive hydrogen corona of Mars, resulting in a significant flux of energetic neutral atoms (ENAs). As these solar wind hydrogen ENAs precipitate into the upper atmosphere, they can experience electron attachment or detachment, resulting in populations of H− and H+, respectively, with upstream velocity. We seek to characterize the behavior of H− in the ionosphere of Mars through a combination of in situ data analysis and mathematical models. Observations indicate that measurable H− precipitation in the ionosphere of Mars is rare, occurring during only 1.8% of available observations. These events occur primarily during high energy solar wind conditions near perihelion. We also compare H− fluxes to those of H+ and find that H− fluxes are ∼4.5 times less than H+, indicating preferential conversion of hydrogen ENAs to H+. We develop a simple model describing the evolution of the charged and neutral fraction of ENAs and H− ions versus altitude. We find that 0.29%–0.78% of ENAs are converted to H− for solar wind energies 1–3 keV. We also predict that the effects of photodetachment on the H‐H− system are non‐negligible.
The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions: insights from a single-arm, phase II trial
Authors: Cheng Bo , Li Caichen , Li Jianfu , Gong Longlong , Liang Peng , Chen Ying , Zhan Shuting , Xiong Shan , Zhong Ran , Liang Hengrui , Feng Yi , Wang Runchen , Wang Haixuan , Zheng Hongbo , Liu Jun , Zhou Chengzhi , Shao Wenlong , Qiu Yuan , Sun Jiancong , Xie Zhanhong , Liang Zhu , Yang Chenglin , Cai Xiuyu , Su Chunxia , Wang Wei , He Jianxing , Liang Wenhua 
Published: April 2024

AbstractImmune checkpoint inhibitors targeting the programmed cell death-1 (PD-1) protein significantly improve survival in patients with advanced non-small-cell lung cancer (NSCLC), but its impact on early-stage ground-glass opacity (GGO) lesions remains unclear. This is a single-arm, phase II trial (NCT04026841) using Simon’s optimal two-stage design, of which 4 doses of sintilimab (200 mg per 3 weeks) were administrated in 36 enrolled multiple primary lung cancer (MPLC) patients with persistent high-risk (Lung-RADS category 4 or had progressed within 6 months) GGOs. The primary endpoint was objective response rate (ORR). T/B/NK-cell subpopulations, TCR-seq, cytokines, exosomal RNA, and multiplexed immunohistochemistry (mIHC) were monitored and compared between responders and non-responders. Finally, two intent-to-treat (ITT) lesions (pure-GGO or GGO-predominant) showed responses (ORR: 5.6%, 2/36), and no patients had progressive disease (PD). No grade 3–5 TRAEs occurred. The total response rate considering two ITT lesions and three non-intent-to-treat (NITT) lesions (pure-solid or solid-predominant) was 13.9% (5/36). The proportion of CD8+ T cells, the ratio of CD8+/CD4+, and the TCR clonality value were significantly higher in the peripheral blood of responders before treatment and decreased over time. Correspondingly, the mIHC analysis showed more CD8+ T cells infiltrated in responders. Besides, responders’ cytokine concentrations of EGF and CTLA-4 increased during treatment. The exosomal expression of fatty acid metabolism and oxidative phosphorylation gene signatures were down-regulated among responders. Collectively, PD-1 inhibitor showed certain activity on high-risk pulmonary GGO lesions without safety concerns. Such effects were associated with specific T-cell re-distribution, EGF/CTLA-4 cytokine compensation, and regulation of metabolism pathways.
Development and validation of a new algorithm for improved cardiovascular risk prediction
Authors: Hippisley-Cox Julia , Coupland Carol A. C. , Bafadhel Mona , Russell Richard E. K. , Sheikh Aziz , Brindle Peter , Channon Keith M. 
Published: April 2024

AbstractQRISK algorithms use data from millions of people to help clinicians identify individuals at high risk of cardiovascular disease (CVD). Here, we derive and externally validate a new algorithm, which we have named QR4, that incorporates novel risk factors to estimate 10-year CVD risk separately for men and women. Health data from 9.98 million and 6.79 million adults from the United Kingdom were used for derivation and validation of the algorithm, respectively. Cause-specific Cox models were used to develop models to predict CVD risk, and the performance of QR4 was compared with version 3 of QRISK, Systematic Coronary Risk Evaluation 2 (SCORE2) and atherosclerotic cardiovascular disease (ASCVD) risk scores. We identified seven novel risk factors in models for both men and women (brain cancer, lung cancer, Down syndrome, blood cancer, chronic obstructive pulmonary disease, oral cancer and learning disability) and two additional novel risk factors in women (pre-eclampsia and postnatal depression). On external validation, QR4 had a higher C statistic than QRISK3 in both women (0.835 (95% confidence interval (CI), 0.833–0.837) and 0.831 (95% CI, 0.829–0.832) for QR4 and QRISK3, respectively) and men (0.814 (95% CI, 0.812–0.816) and 0.812 (95% CI, 0.810–0.814) for QR4 and QRISK3, respectively). QR4 was also more accurate than the ASCVD and SCORE2 risk scores in both men and women. The QR4 risk score identifies new risk groups and provides superior CVD risk prediction in the United Kingdom compared with other international scoring systems for CVD risk.
An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial
Authors: Saraf Amit , Gurjar Rohan , Kaviraj Swarnendu , Kulkarni Aishwarya , Kumar Durgesh , Kulkarni Ruta , Virkar Rashmi , Krishnan Jayashri , Yadav Anjali , Baranwal Ekta , Singh Ajay , Raghuwanshi Arjun , Agarwal Praveen , Savergave Laxman , Singh Sanjay ,   the GEMCOVAC-OM Study Investigators, Pophale Himanshu , Shende Prakash , Shinde Ravindra Baban , Vikhe Vikram , Karmalkar Abhishek , Deshmukh Bhaskar , Giri Krishna , Deshpande Shrikant , Bulle Ajay , Siddiqui Md. Sabah , Borthakur Swapnav , Tummuru V. Reddy , Rao A. Venkateshwar , Shukla Dhaiwat , Jain Manish Kumar , Bhardwaj Pankaj , Supe Pravin Dinkar , Das Manoja Kumar , Lahoti Manoj , Barge Vijaykumar 
Published: April 2024

AbstractHere we conducted a multicenter open-label, randomized phase 2 and 3 study to assess the safety and immunogenicity of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron-specific (BA.1/B.1.1.529), monovalent, thermostable, self-amplifying mRNA vaccine, GEMCOVAC-OM, when administered intradermally as a booster in healthy adults who had received two doses of BBV152 or ChAdOx1 nCoV-19. GEMCOVAC-OM was well tolerated with no related serious adverse events in both phase 2 and phase 3. In phase 2, the safety and immunogenicity of GEMCOVAC-OM was compared with our prototype mRNA vaccine GEMCOVAC-19 (D614G variant-specific) in 140 participants. At day 29 after vaccination, there was a significant rise in anti-spike (BA.1) IgG antibodies with GEMCOVAC-OM (P < 0.0001) and GEMCOVAC-19 (P < 0.0001). However, the IgG titers (primary endpoint) and seroconversion were higher with GEMCOVAC-OM (P < 0.0001). In phase 3, GEMCOVAC-OM was compared with ChAdOx1 nCoV-19 in 3,140 participants (safety cohort), which included an immunogenicity cohort of 420 participants. At day 29, neutralizing antibody titers against the BA.1 variant of SARS-CoV-2 were significantly higher than baseline in the GEMCOVAC-OM arm (P < 0.0001), but not in the ChAdOx1 nCoV-19 arm (P = 0.1490). GEMCOVAC-OM was noninferior (primary endpoint) and superior to ChAdOx1 nCoV-19 in terms of neutralizing antibody titers and seroconversion rate (lower bound 95% confidence interval of least square geometric mean ratio >1 and difference in seroconversion >0% for superiority). At day 29, anti-spike IgG antibodies and seroconversion (secondary endpoints) were significantly higher with GEMCOVAC-OM (P < 0.0001). These results demonstrate that GEMCOVAC-OM is safe and boosts immune responses against the B.1.1.529 variant. Clinical Trial Registry India identifier: CTRI/2022/10/046475.
The association between gray matter volume in the hippocampal subfield and antidepressant efficacy mediated by abnormal dynamic functional connectivity
Authors: Kuai Changxiao , Pu Jiayong , Wang Donglin , Tan Zhonglin , Wang Yan , Xue Shao-Wei 
Published: April 2024

AbstractAn abnormality of structures and functions in the hippocampus may have a key role in the pathophysiology of major depressive disorder (MDD). However, it is unclear whether structure factors of the hippocampus effectively impact antidepressant responses by hippocampal functional activity in MDD patients. We collected longitudinal data from 36 MDD patients before and after a 3-month course of antidepressant pharmacotherapy. Additionally, we obtained baseline data from 43 healthy controls matched for sex and age. Using resting-state functional magnetic resonance imaging (rs-fMRI), we estimated the dynamic functional connectivity (dFC) of the hippocampal subregions using a sliding-window method. The gray matter volume was calculated using voxel-based morphometry (VBM). The results indicated that patients with MDD exhibited significantly lower dFC of the left rostral hippocampus (rHipp.L) with the right precentral gyrus, left superior temporal gyrus and left postcentral gyrus compared to healthy controls at baseline. In MDD patients, the dFC of the rHipp.L with right precentral gyrus at baseline was correlated with both the rHipp.L volume and HAMD remission rate, and also mediated the effects of the rHipp.L volume on antidepressant performance. Our findings suggested that the interaction between hippocampal structure and functional activity might affect antidepressant performance, which provided a novel insight into the hippocampus-related neurobiological mechanism of MDD.
The quasi-xgamma frailty model with survival analysis under heterogeneity problem, validation testing, and risk analysis for emergency care data
Authors: Loubna Hamami , Goual Hafida , Alghamdi Fatimah M. , Mustafa Manahil SidAhmed , Tekle Mekiso Getachew , Ali M. Masoom , Al-Nefaie Abdullah H. , Alsuhabi Hassan , Ibrahim Mohamed , Yousof Haitham M. 
Published: April 2024

AbstractFrailty models are important for survival data because they allow for the possibility of unobserved heterogeneity problem. The problem of heterogeneity can be existed due to a variety of factors, such as genetic predisposition, environmental factors, or lifestyle choices. Frailty models can help to identify these factors and to better understand their impact on survival. In this study, we suggest a novel quasi xgamma frailty (QXg-F) model for the survival analysis. In this work, the test of Rao–Robson and Nikulin is employed to test the validity and suitability of the probabilistic model, we examine the distribution’s properties and evaluate its performance in comparison with many relevant cox-frailty models. To show how well the QXg-F model captures heterogeneity and enhances model fit, we use simulation studies and real data applications, including a fresh dataset gathered from an emergency hospital in Algeria. According to our research, the QXg-F model is a viable replacement for the current frailty modeling distributions and has the potential to improve the precision of survival analyses in a number of different sectors, including emergency care. Moreover, testing the ability and the importance of the new QXg-F model in insurance is investigated using simulations via different methods and application to insurance data.
Exogenous oxytocin increases gaze to humans in male cats
Authors: Hattori Madoka , Kinoshita Kodzue , Saito Atsuko , Yamamoto Shinya 
Published: April 2024

AbstractAlthough oxytocin (OT) plays a role in bonding between heterospecifics and conspecifics, the effects of OT on the formation of such interspecific social behavior have only been investigated between humans and dogs (Canis familiaris). In this study, for comparative evaluation of the effects of OT between dog–human and cat–human social interaction, we investigated the effects of exogenous OT on the behavior of domestic cats (Felis silvestris catus) toward humans. We intranasally administered OT or saline to 30 cats using a nebulizer and recorded their behavior (gaze, touch, vocalization, and proximity). The results showed an interaction between the administration condition and sex for gaze duration. Post hoc analyses revealed a significant increase in gaze in the OT condition in male cats but not in females. There were no significant differences in gaze toward owners and strangers in any condition or sex. The male-specific OT-mediated increase in gaze toward humans observed in this study differs from previous research on dogs wherein such effects were observed only in females. These findings suggest an overall effect of exogenous OT on cats’ social relationship with humans as well as the possibility of different mechanisms between cat–human and dog–human relationships.
The work to swing limbs in humans versus chimpanzees and its relation to the metabolic cost of walking
Authors: Luciano Francesco , Ruggiero Luca , Minetti Alberto E. , Pavei Gaspare 
Published: April 2024

AbstractCompared to their closest ape relatives, humans walk bipedally with lower metabolic cost (C) and less mechanical work to move their body center of mass (external mechanical work, WEXT). However, differences in WEXT are not large enough to explain the observed lower C: humans may also do less work to move limbs relative to their body center of mass (internal kinetic mechanical work, WINT,k). From published data, we estimated differences in WINT,k, total mechanical work (WTOT), and efficiency between humans and chimpanzees walking bipedally. Estimated WINT,k is ~ 60% lower in humans due to changes in limb mass distribution, lower stride frequency and duty factor. When summing WINT,k to WEXT, between-species differences in efficiency are smaller than those in C; variations in WTOT correlate with between-species, but not within-species, differences in C. These results partially support the hypothesis that the low cost of human walking is due to the concerted low WINT,k and WEXT.
Comparative transcriptional analysis identifies genes associated with the attenuation of Theileria parva infected cells after long-term in vitro culture
Authors: van der Heijden Elisabeth M. D. L. , Lefevre Lucas , Gossner Anton , Tzelos Thomas , Connelley Timothy K. , Hassan Musa A. 
Published: April 2024

AbstractAutologous administration of attenuated Theileria parva-infected cells induces immunity to T. parva in cattle. The mechanism of attenuation, however, is largely unknown. Here, we used RNA sequencing of pathogenic and attenuated T. parva-infected T-cells to elucidate the transcriptional changes underpinning attenuation. We observed differential expression of several host genes, including TRAIL, PD-1, TGF-β and granzymes that are known to regulate inflammation and proliferation of infected cells. Importantly, many genes linked with the attenuation of the related T. annulata-infected cells were not dysregulated in this study. Furthermore, known T. parva antigens were not dysregulated in attenuated relative to pathogenic cells, indicating that attenuation is not due to enhanced immunogenicity. Overall this study suggests that attenuation is driven by a decrease in proliferation and restoration of the inflammatory profile of T. parva-infected cells. Additionally, it provides a foundation for future mechanistic studies of the attenuation phenotype in Theileria-infected cells.
Electrophysiological cardiovascular MR: procedure-ready mesh model generation for interventional guidance based on non-selective excitation compressed sensing whole heart imaging
Authors: Jahnke Cosima , Darma Angeliki , Lindemann Frank , Oebel Sabrina , Hilbert Sebastian , Bode Kerstin , Stehning Christian , Smink Jouke , Paetsch Ingo 
Published: April 2024

AbstractFully CMR-guided electrophysiological interventions (EP-CMR) have recently been introduced but data on the optimal CMR imaging protocol are scarce. This study determined the clinical utility of 3D non-selective whole heart steady-state free precession imaging using compressed SENSE (nsWHcs) for automatic segmentation of cardiac cavities as the basis for targeted catheter navigation during EP-CMR cavo-tricuspid isthmus ablation. Fourty-two consecutive patients with isthmus-dependent right atrial flutter underwent EP-CMR radiofrequency ablations. nsWHcs succeeded in all patients (nominal scan duration, 98 ± 10 s); automatic segmentation/generation of surface meshes of right-sided cavities exhibited short computation times (16 ± 3 s) with correct delineation of right atrium, right ventricle, tricuspid annulus and coronary sinus ostium in 100%, 100%, 100% and 95%, respectively. Point-by-point ablation adhered to the predefined isthmus line in 62% of patients (26/42); activation mapping confirmed complete bidirectional isthmus block (conduction time difference, 136 ± 28 ms). nsWHcs ensured automatic and reliable 3D segmentation of targeted endoluminal cavities, multiplanar reformatting and image fusion (e.g. activation time measurements) and represented the basis for precise real-time active catheter navigation during EP-CMR ablations of isthmus-dependent right atrial flutter. Hence, nsWHcs can be considered a key component in order to advance EP-CMR towards the ultimate goal of targeted substrate-based ablation procedures.
Antibody-blocking of a tick transporter impairs Anaplasma phagocytophilum colonization in Haemaphysalis longicornis ticks
Authors: Namjoshi Prachi , Lubembe Donald M. , Sultana Hameeda , Neelakanta Girish 
Published: April 2024

AbstractThe invasive Asian longhorned tick Haemaphysalis longicornis that vectors and transmits several animal pathogens is significantly expanding in the United States. Recent studies report that these ticks also harbor human pathogens including Borrelia burgdorferi sensu lato, Babesia microti, and Anaplasma phagocytophilum. Therefore, studies that address the interactions of these ticks with human pathogens are important. In this study, we report the characterization of H. longicornis organic anion-transporting polypeptides (OATPs) in interactions of these ticks with A. phagocytophilum. Using OATP-signature sequence, we identified six OATPs in the H. longicornis genome. Bioinformatic analysis revealed that H. longicornis OATPs are closer to other tick orthologs rather than to mammalian counterparts. Quantitative real-time PCR analysis revealed that OATPs are highly expressed in immature stages when compared to mature stages of these ticks. In addition, we noted that the presence of A. phagocytophilum upregulates a specific OATP in these ticks. We also noted that exogenous treatment of H. longicornis with xanthurenic acid, a tryptophan metabolite, influenced OATP expression in these ticks. Immunoblotting analysis revealed that antibody generated against Ixodes scapularis OATP cross-reacted with H. longicornis OATP. Furthermore, treatment of H. longicornis with OATP antibody impaired colonization of A. phagocytophilum in these ticks. These results not only provide evidence that the OATP-tryptophan pathway is important for A. phagocytophilum survival in H. longicornis ticks but also indicate OATP as a promising candidate for the development of a universal anti-tick vaccine to target this bacterium and perhaps other rickettsial pathogens of medical importance.
Conspiracy beliefs and perceptual inference in times of political uncertainty
Authors: Leclercq Salomé , Szaffarczyk Sébastien , Leptourgos Pantelis , Yger Pierre , Fakhri Alexandra , Wathelet Marielle , Bouttier Vincent , Denève Sophie , Jardri Renaud 
Published: April 2024

AbstractSociopolitical crises causing uncertainty have accumulated in recent years, providing fertile ground for the emergence of conspiracy ideations. Computational models constitute valuable tools for understanding the mechanisms at play in the formation and rigidification of these unshakeable beliefs. Here, the Circular Inference model was used to capture associations between changes in perceptual inference and the dynamics of conspiracy ideations in times of uncertainty. A bistable perception task and conspiracy belief assessment focused on major sociopolitical events were administered to large populations from three polarized countries. We show that when uncertainty peaks, an overweighting of sensory information is associated with conspiracy ideations. Progressively, this exploration strategy gives way to an exploitation strategy in which increased adherence to conspiracy theories is associated with the amplification of prior information. Overall, the Circular Inference model sheds new light on the possible mechanisms underlying the progressive strengthening of conspiracy theories when individuals face highly uncertain situations.