bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depressive symptoms associated with brain morphometry in Mild Cognitive Impairment stage due to Alzheimer’s and Parkinson’s disease
Authors: Tatiana-Danai Dimitriou , A Tsapanou , N Mourtzi , M Hatzopoulou , V Kamtsadeli , N Tsinia . , A Zagka , M Koustimpi , C. Tzavara , P Toulas , J Papatriantafyllou 
Published: April 2024

Objectives: Although there are studies linking depressive symptoms with psychiatric diseases, and then, with brain morphometry, scarce is the literature examining the association between depressive symptoms and brain morphometry in the prodromal stage of neurodegenerative disorders. In the current analysis, we used a fair sample of Mild Cognitive Impairment (MCI) stage due to Alzheimer’s disease (AD) and Parkinson’s disease (PD) patients, to examine the association between different depressive symptoms and a large variety of brain morphometric factors.
Methods/ Design: Our sample consisted of 352 patients. The Geriatric Depression Scale (GDS) was used for the association with brain measurements. Principal Components Analysis (PCA) and regression models were used for the analyses. Age, sex, years of education, Addenbrooke’s cognitive examination revised (ACE-R), and estimated total intracranial volume were used as covariates.
Results: Factor3 was significantly and positively correlated with GDS total, Dysthymia, Anxiety and Hopelessness. r_factor1, r_factor2 and r_factor5 were significantly and positively correlated with Anxiety, while r_factor5 was also correlated with GDS total. Concerning volumes, v_factor3 was found to be correlated with GDS total, Dysthymia, Anxiety and Hopelessness.
Conclusions: The association between depressive symptoms and upcoming neurodegenerative disorders is reflected in human brain structural alterations, suggesting specific modifications in network-like patterns and neuronal connectivity. Characterizing differences in the morphometry of brain regions among MCI patients with depressive symptoms may aid the early diagnosis and treatment of these symptoms.
Retrospective Study of Various Factors In Pediatric To Severe Dengue Infection
Authors: Hossain Chowdhury Mohammad Sazzad , Islam Md. Obaidul , Asaduzzaman Md. 
Published: April 2024

Introduction: Dengue epidemics are known to have occurred over the last three centuries in tropical, subtropical and temperate areas of the world. Annually a 100 million cases of Dengue fever and half a million cases of dengue hemorrhagic fever (DHF) occur in the world with a case fatality in Asian countries of 0.5%–3.5%. Objective: To assess the various factors in pediatric to severe dengue infection. Methods: A hospital-based Retrospective study was conducted at Department Of Paediatric, Mugda Medical College Hospital, Dhaka, Bangladesh from October to December 2023. Number of patients included in the study was 50. In children with high degree clinical suspicion of Dengue infection NS 1 antigen (who came within first 48 hours of fever) and/or Dengue antibody IgM, IgG (who came after five days of fever) were performed. Positive Dengue cases were taken written informed consent & interviewed on the risk factors of Dengue infection. Data related to patients demography, risk factors, clinical presentation, pattern of Dengue infection and outcome were documented on the pre-structured questionnaire. Results: The study was enrolled 100 patients of suspected dengue fever of whom 50 (50.0%) were serologically confirmed to have dengue infection. 30 (60%) patients were males and 20 (40%) were females. 38 (76%) patients had classic dengue fever while 12 (24%) fulfilled the criteria of dengue hemorrhagic fever. Of those patients with dengue hemorrhagic fever, 6 patients had developed dengue shock syndrome. Among the study 44 (88%) from urban and 6 (12%) rural area patients. All cases and is the most common symptom followed by headache, myalgia, vomiting etc. Hemorrhagic manifestations were seen that included petechiae, ecchymosis, gum bleeding, hematuria, malena, hematemesis and epistaxis. Most common complicationswere hepatic dysfunction, renal failure, multi organ failure, encephalopathy and ARDS. Among 50 suspected dengue cases 38 (76.0%) cases were serologically dengue positive. Among the 38 serologically dengue positive patients 17 (44.7%) were NS1 antigen positive, 13 (34.2%) IgM antibodies and 8(21.0%) both IgM and IgG antibodies positive. The distribution of the serologically dengue positive patients out of 50 clinically suspected cases. Conclusion: Dengue is one amongst the key causes of dedifferentiated fever. It presents as an extremely broad wellness and is hardly recognized as a clinical entity by primary health care physicians. This study highlights the practician the importance of break bone fever to clinicians within the areas of medical specialty, manifestations, complications and outcome of the wellness
Prispevek k poznavanju socialne zgradbe mesta na primeru naselja Lenart v Slovenskih goricah
Authors: Drozg Vladimir 
Published: April 2024

V članku je prikazan pristop k spoznavanju socialne zgradbe mesta na podlagi socialnih lastnosti uporabnikov posameznih dejavnosti v naselju Lenart. Socialna zgradba mesta se nanaša tudi na socialno diferenciranost posameznih dejavnosti, ki so namenjene zadovoljevanju potreb prebivalcev in obiskovalcev mesta. Teoretska podlaga besedila je spoznanje, da posamezniki podobnih socialnih lastnosti zadovoljujejo svoje potrebe na podobnih ali na istih krajih. V ta namen smo popisali kraje, kjer je mogoče zadovoljevati človekove potrebe in jim pripisali socialne vsebine. Izkazalo se je, da je socialna diferenciranost v Lenartu majhna. Večina krajev se razlikuje glede na starostno skupino uporabnikov.
Interdisciplinary methodological approach to the process of brownfield revitalisation of traditional industrial areas
Authors: Lorber Lučka 
Published: April 2024

Traditional industrial regions in the South-East Europe (SEE) represent an underexplored economic value. Revitalisation is delayed and hindered because of legal, financial, environmental and image problems. This weakens competitive investment position for cities and for SEE as a European region. This paper aims at presenting interdisciplinary methodological approach used in a brownfield revitalisation research project. The research work methodology applies the endogenous approach (“bottom up”) on a basis of newly defined land use category of brownfields by the local community. Geography science enjoys an advantage of complexity of understanding spatial issues. This enables geographers to coordinate and harmonize interests between the owners, stakeholders, legislation and human resources. In addition to geographical areas (economic, traffic, demographic, environmental and regional geography) directly involved in the project applicative research, this also includes collaboration of architects, lawyers and economists. The form of applicative research work presented is being developed within the international Revitalisation of Traditional Industrial Areas in South-East Europe (ReTInA) project. The project is funded in the context of the SEE European Transnational Cooperation Programme 2009/12, involving ten partners from seven countries. The main result of the project will be the new methodology and tools to boost brownfield revitalisation in the municipalities and in old industrial areas of SEE region.
Model trajnostne revitalizacije starih industrijskih območij
Authors: Kokot Krajnc Mojca 
Published: April 2024

Revitalizacija degradiranih območij, med katerimi je največ starih industrijskih območij, je velik potencial za izvajanje trajnostnega prostorskega razvoja. Njihov ponoven razvoj mora biti usmerjen vzdržno, s čimer se preprečuje onesnaženost okolja ter se spodbuja socialna vključenost in novi ekonomski izzivi. Dosedanji modeli trajnostne revitalizacije degradiranih območij v celoti ne uresničujejo zahtev vzdrženga razvoja, ker v praksi niso enakomerno vključene vse komponente, torej poleg ekonomske tudi socialna in okoljska. Zato je v članku predstavljen model trajnostne revitalizacije starih industrijskih območij, ki sloni na celovitosti in enakovrednem vključevanju vseh komponent razvoja, ker so le te vzročno in posledično povezane ter skupaj sestavljajo celoto. Holističen model trajnostne revitalizacije, kakor smo ga poimenovali, je sestavljen iz štirih komponent: naravni kapital, trajnostna družba, lokalno gospodarstvo in snovni krogotok. Model, ki smo ga razvili, pa se udejanja na primeru revitalizacije starih industrijskih območij (primer eko industrijski park).
Mednarodna prepoznavnost Oddelka za geografijo Filozofske fakultete Univerze v Mariboru
Authors: Lorber Lučka 
Published: April 2024

Oddelek za geografijo je mednarodno prepoznaven v ožjem regionalnem, evropskem in globalnem prostoru. Pri razvoju geografske stroke se povezuje z geografskimi oddelki drugih univerz, prav tako pa veliko pozornost namenja proučevanju obmejnih in čezmejnih prostorskih problemov. Na področju znanstvenoraziskovalnega in izobraževalnega dela ima pomembno vlogo pri razumevanju prostorske stvarnosti v širšem kontekstu proučevanja družbenih, kulturnih in političnih vidikov značilnih za posamezno obdobje v zadnjih petdesetih letih. Mednarodno delovanje študentov in profesorjev se je še posebej razmahnilo po vstopu Slovenije v Evropsko unijo. Profesorji sodelujejo na mednarodnih znanstvenih kongresih, gostujočih predavanjih in na poletnih šolah. Mednarodna aktivnost se odraža v vedno večjem številu objav znanstvenih člankov v uglednih mednarodnih revijah in prispevkih v znanstvenih monografijah. S sodelovanjem v znanstvenoraziskovalnih projektih se krepi mednarodna prepoznavnost Oddelka za geografijo Filozofske fakultete Univerze v Mariboru.
Sociological survey of the current status and nature conservation in relation to the development of tourism in the cadastral of Tatranská Lomnica
Authors: Ližbetinová Michaela 
Published: April 2024

The main part of the cadastral of Tatranská Lomnica belongs to the Tatra National Park. The activity of humans is limited there because nature is protected by law. This is the first time there will be building of new accommodation and sport facilities, especially after November 2004 when was severe wind damage in the Tatra region. In this thesis we focus on the opinions of respondents on the current state of the environment and its protection in the municipalities of the cadastral Tatranská Lomnica in relation to the present tourist business development.
Poznavanje trajnostnega razvoja na regionalni ravni na primeru Dravinjske doline
Authors: Vovk Korže Ana 
Published: April 2024

Poznavanje trajnostnega razvoja na regionalni ravni je ključ za načrtovanje takih dejavnosti, ki temeljijo na varovanju ekosistemov, na povezovanju ljudi in vključevanju vseh sektorjev. Zato je bila izvedena raziskava o poznavanju trajnostnega razvoja v Dravinjski dolini. Namreč na tem območju so bili v zadnjih sedmih letih izpeljani mnogi projekti na temelju upoštevanja trajnostnega razvoja. Raziskava je vključila 250 ljudi, anketne vprašalnike pa je vrnilo 100 ljudi. Vprašanja so bila vezana na vrednotenje pomena kulturne in naravne dediščine, večnamenske rabe podeželja, naložb v človeške vire, naložb v inovacije, naložb v kvalitetno kmetijsko proizvodnjo, na trajnostno gospodarjenje z naravnimi viri, ohranjanje kulturne pokrajine in pomembnost varovanja okolja. Osebe , ki so odgovarjale na anketni vprašalnik živijo v občinah Zreče, Slovenske Konjice, Oplotnica, Vitanje, Poljčane, Makole in Majšperk. Ugotovitve kažejo, da ljudje ne dajajo največjo težo zgolj denarju in ugodobju, ampak aktivni participaciji in ohranjeni naravi. Najvišji deleži podpore gredo ustvarjanju zelenih delovnih mest, izboljšanju življenja na podeželju in povečanju prepoznavnosti Dravinjske doline z lastno blagovno znamko.
El desarrollo de plástico biodegradable a partir del cáñamo por estímulo microbiano
Authors: Moscoso-Gama Johanna Marcela , Sanabria-Cuervo María Camila , Sánchez-Rubiano Ana María 
Published: April 2024

Actualmente varias industrias de diversa índole han apostado por el uso de Cannabis sativa con diferentes fines, en esta ocasión se resalta la capacidad que tiene la fibra del tallo de cáñamo en conjunto con la bacteria Ralstonia eutropha para la generación de plásticos biodegradables, aprovechando su potencial para la generación de PHB (Polihidroxibutirato). En este artículo de revisión se sustenta el análisis de fuentes como artículos científicos y trabajos de investigación relacionados con la manipulación artesanal e industrial de las fibras de cáñamo, así como también investigaciones previas con respecto a la producción de PHA por parte de la bacteria Ralstonia eutropha. La perspectiva es desarrollar una metodología con recursos de fácil acceso en Colombia. Los resultados arrojan que las investigaciones realizadas recientemente y la materia prima son un buen factor en cuanto economía, manejo y progreso; adicionalmente diferentes estudios evidencian que la yuca se ha reconocido como una gran fuente de carbono que permite aumentar el potencial de producción de PHB por parte de la bacteria. Se concluye que su compostaje no requiera de terceros, solamente del ambiente gracias al poder que posee la Ralstonia eutropha de producir PHB, y que bajo condiciones de estrés fisiológico es capaz de degradarse completamente permitiendo disminuir el impacto de la descomposición del material en el medio ambiente, sin contaminaciones o microplásticos residuales.
Psoas Abscess with Pott Spine: A Case Report
Authors: G Evangeline , Patel Rudra , Patel Vaishnavi , Rathod Mrudangsinh 
Published: April 2024

Abstract
Introduction Psoas abscess is the accumulation of fluid around the iliopsoas muscle. Potts spine also called spinal tuberculosis occurs due to extra pulmonary tuberculosis. The most common etiology is staphylococcus aureus. Common clinical manifestations include high grade fever, back pain, weight loss and lump in groin. Condition can be treated by anti-tubercular therapy and sensitive Anti-microbials with analgesics for symptomatic relief. Drainage and surgical procedures can be carried out to remove the accumulated fluid based on inter individual severity. In this case study, we report a rare case of Psoas Abscess with Pott Spine.
Case Presentation A 28-year female presented with complaints of lump pain in groin, abdominal pain, flank pain, fever and weight loss. Medical history showed untreated tuberculosis since 5-6 months. MRI Pelvis showed right psoas abscess measuring approximately 7cm x 6.5cm x 14cm while MRI Dorso-lumbar Spine showed Potts spine. The drainage clearance procedure was performed, and patient was prescribed with anti-tuberculous and anti-microbial drugs during hospitalisation. On discharge patient’s condition was improved.
Conclusion The condition is rare. Potts spine, if not diagnosed early may delay the prognosis and cause psoas abscess so it must be treated in time to reduce morbidity and mortality. Follow-up is essential to prevent the relapse of Extra-pulmonary tuberculosis.
Genetic determinants of centenarian longevity, as quantified by the 'CentPGS' score, are associated with a lower risk of multiple age-related diseases and a longer healthspan.
Authors: Sasaki Takashi , Tadaka Shu , Hirata Takumi , Nishimoto Yoshinori , Shikimoto Ryo , Abe Yukiko , Shiohama Aiko , Shirota Matsuyuki , Motoike Ikuko , Tamiya Gen , Kinoshita Kengo , Yamamoto Masayuki , Latysheva Natasha , Ledsam Joseph , Kayama Hiroshi , Momozawa Yukihide , Kubo Michiaki , Inoue Ituro , Ikeuchi Takeshi , Mori Hiroshi , Takebayashi Toru , Okano Hideyuki , Suematsu Makoto , Kosaki Kenjiro , Hirose Nobuyoshi , Arai Yasumichi 
Published: April 2024

Abstract
Centenarians exhibit remarkable longevity, and exploring the genetic determinants of that longevity is crucial for understanding the mechanisms of human ageing. Although APOE4 is the most common implicated negative factor in longevity, other genetic factors and their associated phenotypes are not fully understood. We conducted a genome-wide association study (GWAS) of 964 Japanese centenarians (including 173 supercentenarians) and 7,306 controls to identify the genetic components of longevity and the correlated phenotypes. GWAS summary statistics revealed that the genetic components of longevity were negatively associated with the risk of multiple age-related diseases and biometrics. Survival analysis indicated that a polygenic score derived from these summary statistics, called CentPGS, was correlated with healthspan in a cohort of healthy older people. This association was independent of APOE4 genotype and sex, suggesting that CentPGS is a promising genetic indicator of healthspan and may be used in future investigations into healthy longevity.
A tailored small-group instruction intervention in mathematics benefits low achievers – evidence from two stratified randomized trials
Authors: Rosholm Michael , Tonnesen Pia , Rasmussen Klaus , Overgaard Steffen , Færch Julie , Malm Signe , Harder Jimmy 
Published: April 2024

Abstract
Running two separate two-stage randomized trials, we implement and test three variants of a small group instruction intervention aimed at improving mathematics competencies for the 20% lowest achievers in mathematics in grades 2 and 8 in Danish public schools. We calculate immediate impacts on math competencies as well as impacts in the medium term and conduct cost-effectiveness analyses of the different intervention arms. The context is the Scandinavian welfare state with an already high quality public school system. Nevertheless, we find very large positive and cost-effective impacts of several intervention variants, some of which persist in the medium term. In particular, interventions in grade 2 tend to persist, while 8th grade interventions tend to fade out in the medium term.
Winners, losers or ties? What game theory contributes to analysing a care network for patients with amyothrophic lateral sclerosis. A pilot project with a mixed-method approach.
Authors: Ates Gülay , Jaspers Birgit , Weydt Patrick , Mücke Martin , Radbruch Lukas 
Published: April 2024

Abstract

The expansion of palliative care for patients with amyotrophic lateral sclerosis (ALS) developed in a region of North Rhine-Westphalia rather by chance. A specialist palliative home care team was taken aback by the numerous challenges and significant needs of patients, their caregivers and healthcare professional. A pilot study using mixed methods and a theory-based data analysis helped to comprehend the underlying mechanisms in care networks. Semi-structured expert interviews (n = 15), an assessment of 50 ALS patients and a quantitative survey of 196 hospice and palliative care services were conducted to differentiate and refine the patients’ needs. ALS patients have multifaceted needs, including physical symptoms, psychosocial and financial issues and/or spiritual needs. Addressing these comprehensive needs requires complex solutions. Healthcare professionals demonstrated a greater willingness to provide additional support and allocate more time for appointments with ALS patients compared to patients with other diseases. Sociologically, a network's effectiveness is based on jointly agreed goals. So, social networks and game theories demonstrate that shared network goals are associated with knowledge, network size, heterogeneity, interrelations, and communication. Therefore, it is possible to develop a comprehensive care concept and a regional care network for ALS.
Integrating policy measures into the assessment of household livelihood resilience to climate change in the Pumqu River Basin, Tibetan Plateau
Authors: Wang Yutong , Yan Jianzhong , Wu Ya , Xiong Sihong 
Published: April 2024

Abstract
In the context of climate change, improving household livelihood resilience (HLR) especially in developing areas, has become an important agenda. However, previous studies of assessing HLR have ignored the behaviors of government authorities. Therefore, this study established an HLR evaluation index system based on household endowment and government behaviour from the dimensions of buffer capacity, self-organizing capacity, learning capacity and policy measures. Based on 701 questionnaires from the Pumqu River Basin (PRB), the level of local HLR was assessed and the key indicators that hinder the HLR were identified. The preliminary results indicate that the average HLR value in the PRB was 0.242, with Nyalam county > Dinggye county > Tingri county. In each dimension, the value of policy measures far outweighed the others, indicating policy measures should be integrated into assessing HLR. However, the implementation of policy measures, such as the promotion of new crops and skills training, are still insufficient. Household endowment aspects that hinder the development of HLR are mainly savings, leadership, education level of householders and relationship resources. The research results can provide a reliable basis for local governments to improve policies. In addition, we introduce the implementation experience of certain policies in the research area, providing a reference for other developing countries.
Automating Prostate Volume Acquisition Using Abdominal Ultrasound Scans for Prostate-Specific Antigen Density Calculations
Authors: Bennett Rory Douglas , Barrett Tristan , Sushentsev Nikita , Sanmugalingam Nimalan , Lee Kang-Lung , Gnanapragasam Vincent J. , Tse Zion Tsz Ho 
Published: April 2024

Abstract

Proposed methods for prostate cancer screening are currently prohibitively expensive, inadequate in their detection rates, require highly trained specialists, and/or are invasive, resulting in patient discomfort. These limitations make population-wide screening for prostate cancer challenging. Machine learning techniques applied to abdominal ultrasound scanning may help alleviate some of these disadvantages. Abdominal ultrasound scans are comparatively low cost and exhibit minimal patient discomfort, and machine learning can be applied to mitigate against the high operator-dependent variability of ultrasound scanning. In this study, a state-of-the-art machine learning model was compared to an expert radiologist and trainee radiologist registrars of varying experience when estimating prostate volume from abdominal ultrasound images, a crucial step in detecting prostate cancer using prostate-specific antigen density. The machine learning model calculated prostatic volume by marking out dimensions of the prolate ellipsoid formula from two orthogonal images of the prostate acquired with abdominal ultrasound scans (which could be conducted by operators with minimal experience in a primary care setting). While both the algorithm and the registrars showed high correlation with the expert (r ≥ 0.8) it was found that the model outperformed the trainees in both accuracy (lowest average volume error of 15%) and consistency (lowest IQR of 19% and lowest average volume standard deviation of 13%). The results are promising for the future development of an automated prostate cancer screening workflow using machine learning and abdominal ultrasound scans.