bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attitudes, subjective norms and perceived behavioural control factors influencing Canadian secondary school students’ milk and milk alternatives consumption
Authors: Thompson Carise M , Elliott Susan J , Meyer Samantha , Leatherdale Scott T , Majowicz Shannon E 
Published: March 2024

Abstract

Objective:
The research objectives were to evaluate factors that influence Canadian secondary school students’ milk and milk alternatives (MMA) consumption and to explore associations through age and gender lenses.

Design:
A qualitative design was used, consisting of semi-structured interviews and photo-elicitation methods. Analysis was guided by the Theory of Planned Behaviour (TPB). Deductive and inductive thematic analyses were used to generate themes, charting data based on attributes such as gender and age.

Setting:
Interviews were held virtually or via telephone.

Participants:
Participants were twenty-eight high school students from Ontario, Canada, diverse in terms of gender and age.

Results:
Both desirable and undesirable beliefs about the health outcomes of consuming MMA were commonly discussed. These included health benefits such as strong bones, muscular strength, and growth, and health consequences like unwanted skin conditions, weight gain, and diseases. While boys and girls associated MMA consumption with muscular strength, boys predominantly considered this favourable, while girls discussed outcomes like unwanted skin conditions and weight gain more often. Adolescents’ perspectives on taste/perceived enjoyment, environmentally friendly choices and animal welfare also influenced their MMA preferences. Parental influences were most cited among social factors, which appeared to be stronger during early adolescence. Factors involving cost, time and accessibility affected adolescents’ beliefs about how difficult it was to consume MMA.

Conclusions:
Recommendations for shifting attitudes towards MMA are provided to address unfavourable beliefs towards these products. Interventions to increase MMA consumption among adolescents should include parents and address cost barriers.
Rift Propagation Interacting With Pre‐Existing Microcontinental Blocks
Authors: Qing Jiarong , Liao Jie , Brune Sascha 
Published: March 2024

AbstractRift propagation is a 3D thermo‐mechanical process that often precedes continental breakup. Pre‐existing microcontinental blocks and the associated lithospheric strength heterogeneities influence the style of rift propagation. Interestingly, some rifts propagate into pre‐existing blocks and eventually cut through them (e.g., the Zhongsha Block and the Reed Bank), while others bypass these microcontinental blocks forming distinct overlapping rift branches (e.g., the East African Rift System). In this study, we use 3D numerical models to investigate the interaction between microcontinental blocks and rift propagation under different far‐field extension rates. In doing so, we assess the impact of mantle lithospheric thicknesses and lower crustal rheology on the style of rift propagation. Our models reproduce the two types of rift propagation, characterized by propagating rifts that either split or bypass the pre‐existing microcontinental blocks. We find that lithospheric thickness exerts dominant control, while lower crustal rheology of microcontinental blocks and the extension rate have less effect on rift propagation. Our model results can explain rift propagation patterns, block rotation and strong lithospheric thinning in the South China Sea, the East African Rift System, and the Woodlark Basin.
Perseverance MEDA Atmospheric Pressure Observations—Initial Results
Authors: Harri Ari‐Matti , Paton Mark , Hieta Maria , Polkko Jouni , Newman Claire , Pla‐Garcia Jorge , Leino Joonas , Mäkinen Terhi , Kauhanen Janne , Jaakonaho Iina , Sánchez‐Lavega Agustin , Hueso Ricardo , Genzer Maria , Lorenz Ralph , Lemmon Mark , Vicente‐Retortillo Alvaro , Tamppari Leslie K. , Viudez‐Moreiras Daniel , Torre‐Juarez Manuel de la , Savijärvi Hannu , Rodríguez‐Manfredi Javier A. , Martinez German 
Published: March 2024

AbstractThe Mars2020 Perseverance Rover landed successfully on the Martian surface on the Jezero Crater floor (18.44°N, 77.45°E) at Martian solar longitude, Ls, ∼5° in February 2021. Since then, it has produced highly valuable environmental measurements with a versatile scientific payload including the MEDA (Mars Environmental Dynamics Analyzer) suite of environmental sensors. One of the MEDA systems is the PS pressure sensor system, which weighs 40 g and has an estimated absolute accuracy of better than 3.5 Pa and a resolution of 0.13 Pa. We present initial results from the first 414 sols of Martian atmospheric surface pressure observations by the PS, whose performance was found to meet its specifications. Observed sol‐averaged atmospheric pressures follow an anticipated pattern of pressure variation in the course of the advancing season and are consistent with data from other landing missions. The observed daily pressure amplitude varies by ∼2%–5 % of the sol‐averaged pressure, with absolute amplitude 10–35 Pa in an approximately direct relationship with airborne dust. During a regional dust storm, which began at Ls ∼ 135°, the daily pressure amplitude roughly doubled. The daily pressure variations were found to be remarkably sensitive to the seasonal evolution of the atmosphere. In particular, analysis of the daily pressure signature revealed diagnostic information likely related to the regional scale structure of the atmosphere. Comparison of Perseverance pressure observations with data from other landers reveals the global scale seasonal behavior of Mars' atmosphere.
Finite barrier bound state
Authors: Liu Tao , Bai Kai , Zhang Yicheng , Wan Duanduan , Lai Yun , Chan C. T. , Xiao Meng 
Published: March 2024

AbstractA boundary mode localized on one side of a finite-size lattice can tunnel to the opposite side which results in unwanted couplings. Conventional wisdom tells that the tunneling probability decays exponentially with the size of the system which thus requires many lattice sites before eventually becoming negligibly small. Here we show that the tunneling probability for some boundary modes can apparently vanish at specific wavevectors. Thus, similar to bound states in the continuum, a boundary mode can be completely trapped within very few lattice sites where the bulk bandgap is not even well-defined. More intriguingly, the number of trapped states equals the number of lattice sites along the normal direction of the boundary. We provide two configurations and validate the existence of this peculiar finite barrier-bound state experimentally in a dielectric photonic crystal at microwave frequencies. Our work offers extreme flexibility in tuning the coupling between localized states and channels as well as a new mechanism that facilitates unprecedented manipulation of light.
Cavity-agnostic acoustofluidic manipulations enabled by guided flexural waves on a membrane acoustic waveguide actuator
Authors: Vachon Philippe , Merugu Srinivas , Sharma Jaibir , Lal Amit , Ng Eldwin J. , Koh Yul , Lee Joshua E.-Y. , Lee Chengkuo 
Published: March 2024

AbstractThis article presents an in-depth exploration of the acoustofluidic capabilities of guided flexural waves (GFWs) generated by a membrane acoustic waveguide actuator (MAWA). By harnessing the potential of GFWs, cavity-agnostic advanced particle manipulation functions are achieved, unlocking new avenues for microfluidic systems and lab-on-a-chip development. The localized acoustofluidic effects of GFWs arising from the evanescent nature of the acoustic fields they induce inside a liquid medium are numerically investigated to highlight their unique and promising characteristics. Unlike traditional acoustofluidic technologies, the GFWs propagating on the MAWA’s membrane waveguide allow for cavity-agnostic particle manipulation, irrespective of the resonant properties of the fluidic chamber. Moreover, the acoustofluidic functions enabled by the device depend on the flexural mode populating the active region of the membrane waveguide. Experimental demonstrations using two types of particles include in-sessile-droplet particle transport, mixing, and spatial separation based on particle diameter, along with streaming-induced counter-flow virtual channel generation in microfluidic PDMS channels. These experiments emphasize the versatility and potential applications of the MAWA as a microfluidic platform targeted at lab-on-a-chip development and showcase the MAWA’s compatibility with existing microfluidic systems.
Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies
Authors: Zhou Qian , Meng Yu , Li Daishi , Yao Lei , Le Jiayuan , Liu Yihuang , Sun Yuming , Zeng Furong , Chen Xiang , Deng Guangtong 
Published: March 2024

AbstractFerroptosis is a non-apoptotic form of regulated cell death characterized by the lethal accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate tumor suppressor mechanism and participates in the biological processes of tumors. Intriguingly, mesenchymal and dedifferentiated cancer cells, which are usually resistant to apoptosis and traditional therapies, are exquisitely vulnerable to ferroptosis, further underscoring its potential as a treatment approach for cancers, especially for refractory cancers. However, the impact of ferroptosis on cancer extends beyond its direct cytotoxic effect on tumor cells. Ferroptosis induction not only inhibits cancer but also promotes cancer development due to its potential negative impact on anticancer immunity. Thus, a comprehensive understanding of the role of ferroptosis in cancer is crucial for the successful translation of ferroptosis therapy from the laboratory to clinical applications. In this review, we provide an overview of the recent advancements in understanding ferroptosis in cancer, covering molecular mechanisms, biological functions, regulatory pathways, and interactions with the tumor microenvironment. We also summarize the potential applications of ferroptosis induction in immunotherapy, radiotherapy, and systemic therapy, as well as ferroptosis inhibition for cancer treatment in various conditions. We finally discuss ferroptosis markers, the current challenges and future directions of ferroptosis in the treatment of cancer.
p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence
Authors: Potes Yaiza , Bermejo-Millo Juan C. , Mendes Catarina , Castelão-Baptista José P. , Díaz-Luis Andrea , Pérez-Martínez Zulema , Solano Juan J. , Sardão Vilma A. , Oliveira Paulo J. , Caballero Beatriz , Coto-Montes Ana , Vega-Naredo Ignacio 
Published: March 2024

AbstractDuring aging, muscle regenerative capacities decline, which is concomitant with the loss of satellite cells that enter in a state of irreversible senescence. However, what mechanisms are involved in myogenic senescence and differentiation are largely unknown. Here, we showed that early-passage or “young” C2C12 myoblasts activated the redox-sensitive p66Shc signaling pathway, exhibited a strong antioxidant protection and a bioenergetic profile relying predominantly on OXPHOS, responses that decrease progressively during differentiation. Furthermore, autophagy was increased in myotubes. Otherwise, late-passage or “senescent” myoblasts led to a highly metabolic profile, relying on both OXPHOS and glycolysis, that may be influenced by the loss of SQSTM1/p62 which tightly regulates the metabolic shift from aerobic glycolysis to OXPHOS. Furthermore, during differentiation of late-passage C2C12 cells, both p66Shc signaling and autophagy were impaired and this coincides with reduced myogenic capacity. Our findings recognized that the lack of p66Shc compromises the proliferation and the onset of the differentiation of C2C12 myoblasts. Moreover, the Atg7 silencing favored myoblasts growth, whereas interfered in the viability of differentiated myotubes. Then, our work demonstrates that the p66Shc signaling pathway, which highly influences cellular metabolic status and oxidative environment, is critical for the myogenic commitment and differentiation of C2C12 cells. Our findings also support that autophagy is essential for the metabolic switch observed during the differentiation of C2C12 myoblasts, confirming how its regulation determines cell fate. The regulatory roles of p66Shc and autophagy mechanisms on myogenesis require future attention as possible tools that could predict and measure the aging-related state of frailty and disability.
Metabolism-regulated ferroptosis in cancer progression and therapy
Authors: Ye Lvlan , Wen Xiangqiong , Qin Jiale , Zhang Xiang , Wang Youpeng , Wang Ziyang , Zhou Ti , Di Yuqin , He Weiling 
Published: March 2024

AbstractCancer metabolism mainly includes carbohydrate, amino acid and lipid metabolism, each of which can be reprogrammed. These processes interact with each other to adapt to the complicated microenvironment. Ferroptosis is a regulated cell death induced by iron-dependent lipid peroxidation, which is morphologically different from apoptosis, necrosis, necroptosis, pyroptosis, autophagy-dependent cell death and cuprotosis. Cancer metabolism plays opposite roles in ferroptosis. On the one hand, carbohydrate metabolism can produce NADPH to maintain GPX4 and FSP1 function, and amino acid metabolism can provide substrates for synthesizing GPX4; on the other hand, lipid metabolism might synthesize PUFAs to trigger ferroptosis. The mechanisms through which cancer metabolism affects ferroptosis have been investigated extensively for a long time; however, some mechanisms have not yet been elucidated. In this review, we summarize the interaction between cancer metabolism and ferroptosis. Importantly, we were most concerned with how these targets can be utilized in cancer therapy.
Histone lactylation promotes malignant progression by facilitating USP39 expression to target PI3K/AKT/HIF-1α signal pathway in endometrial carcinoma
Authors: Wei Sitian , Zhang Jun , Zhao Rong , Shi Rui , An Lanfen , Yu Zhicheng , Zhang Qi , Zhang Jiarui , Yao Yuwei , Li Haojia , Wang Hongbo 
Published: March 2024

AbstractHistone lactylation has been reported to involve in tumorigenesis and development. However, its biological regulatory mechanism in endometrial carcinoma (EC) is yet to be reported in detail. In the present study, we evaluated the modification levels of global lactylation in EC tissues by immunohistochemistry and western blot, and it was elevated. The non-metabolizable glucose analog 2-deoxy-d-glucose (2-DG) and oxamate treatment could decrease the level of lactylation so as to inhibit the proliferation and migration ability, induce apoptosis significantly, and arrest the cell cycle of EC cells. Mechanically, histone lactylation stimulated USP39 expression to promote tumor progression. Moreover, USP39 activated PI3K/AKT/HIF-1α signaling pathway via interacting with and stabilizing PGK1 to stimulate glycolysis. The results of present study suggest that histone lactylation plays an important role in the progression of EC by promoting the malignant biological behavior of EC cells, thus providing insights into potential therapeutic strategies for endometrial cancer.
The role of interdecadal climate oscillations in driving Arctic atmospheric river trends
Authors: Ma Weiming , Wang Hailong , Chen Gang , Leung L. Ruby , Lu Jian , Rasch Philip J. , Fu Qiang , Kravitz Ben , Zou Yufei , Cassano John J. , Maslowski Wieslaw 
Published: March 2024

AbstractAtmospheric rivers (ARs), intrusions of warm and moist air, can effectively drive weather extremes over the Arctic and trigger subsequent impact on sea ice and climate. What controls the observed multi-decadal Arctic AR trends remains unclear. Here, using multiple sources of observations and model experiments, we find that, contrary to the uniform positive trend in climate simulations, the observed Arctic AR frequency increases by twice as much over the Atlantic sector compared to the Pacific sector in 1981-2021. This discrepancy can be reconciled by the observed positive-to-negative phase shift of Interdecadal Pacific Oscillation (IPO) and the negative-to-positive phase shift of Atlantic Multidecadal Oscillation (AMO), which increase and reduce Arctic ARs over the Atlantic and Pacific sectors, respectively. Removing the influence of the IPO and AMO can reduce the projection uncertainties in near-future Arctic AR trends by about 24%, which is important for constraining projection of Arctic warming and the timing of an ice-free Arctic.
A molecular T-pentomino for separating BTEX hydrocarbons
Authors: Hartwick Christopher J. , Reinheimer Eric W. , MacGillivray Leonard R. 
Published: March 2024

AbstractMethods to separate molecules (e.g., petrochemicals) are exceedingly important industrially. A common approach for separations is to crystallize a host molecule that either provides an enforced covalent cavity (intrinsic cavity) or packs inefficiently (extrinsic cavity). Here we report a self-assembled molecule with a shape highly biased to completely enclose space and, thereby, pack efficiently yet hosts and allows for the separation of BTEX hydrocarbons (i.e., benzene, toluene, ethylbenzene, xylenes). The host is held together by N → B bonds and forms a diboron assembly with a shape that conforms to a T-shaped pentomino. A T-pentomino is a polyomino, which is a plane figure that tiles a plane without cavities and holes, and we show the molecule to crystallize into one of six polymorphic structures for T-pentomino tiling. The separations occur at mild conditions while rejecting similarly shaped aromatics such as xylene isomers, thiophene, and styrene. Our observation on the structure and tiling of the molecular T-pentomino allows us to develop a theory on how novel synthetic molecules that mimic the structures and packing of polyominoes can be synthesized and—quite counterintuitively—developed into a system of hosts with cavities used for selective and useful separations.
Abnormal thermally-stimulated dynamic organic phosphorescence
Authors: Wang He , Ma Huili , Gan Nan , Qin Kai , Song Zhicheng , Lv Anqi , Wang Kai , Ye Wenpeng , Yao Xiaokang , Zhou Chifeng , Wang Xiao , Zhou Zixing , Yang Shilin , Yang Lirong , Bo Cuimei , Shi Huifang , Huo Fengwei , Li Gongqiang , Huang Wei , An Zhongfu 
Published: March 2024

AbstractDynamic luminescence behavior by external stimuli, such as light, thermal field, electricity, mechanical force, etc., endows the materials with great promise in optoelectronic applications. Upon thermal stimulus, the emission is inevitably quenched due to intensive non-radiative transition, especially for phosphorescence at high temperature. Herein, we report an abnormal thermally-stimulated phosphorescence behavior in a series of organic phosphors. As temperature changes from 198 to 343 K, the phosphorescence at around 479 nm gradually enhances for the model phosphor, of which the phosphorescent colors are tuned from yellow to cyan-blue. Furthermore, we demonstrate the potential applications of such dynamic emission for smart dyes and colorful afterglow displays. Our results would initiate the exploration of dynamic high-temperature phosphorescence for applications in smart optoelectronics. This finding not only contributes to an in-depth understanding of the thermally-stimulated phosphorescence, but also paves the way toward the development of smart materials for applications in optoelectronics.
Retinal photoisomerization versus counterion protonation in light and dark-adapted bacteriorhodopsin and its primary photoproduct
Authors: Malakar Partha , Gholami Samira , Aarabi Mohammad , Rivalta Ivan , Sheves Mordechai , Garavelli Marco , Ruhman Sanford 
Published: March 2024

AbstractDiscovered over 50 years ago, bacteriorhodopsin is the first recognized and most widely studied microbial retinal protein. Serving as a light-activated proton pump, it represents the archetypal ion-pumping system. Here we compare the photochemical dynamics of bacteriorhodopsin light and dark-adapted forms with that of the first metastable photocycle intermediate known as “K”. We observe that following thermal double isomerization of retinal in the dark from bio-active all-trans 15-anti to 13-cis, 15-syn, photochemistry proceeds even faster than the ~0.5 ps decay of the former, exhibiting ballistic wave packet curve crossing to the ground state. In contrast, photoexcitation of K containing a 13-cis, 15-anti chromophore leads to markedly multi-exponential excited state decay including much slower stages. QM/MM calculations, aimed to interpret these results, highlight the crucial role of protonation, showing that the classic quadrupole counterion model poorly reproduces spectral data and dynamics. Single protonation of ASP212 rectifies discrepancies and predicts triple ground state structural heterogeneity aligning with experimental observations. These findings prompt a reevaluation of counter ion protonation in bacteriorhodopsin and contribute to the broader understanding of its photochemical dynamics.
Deficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress
Authors: Zhang Zhe , Leng Xiang Kai , Zhai Yuan Yuan , Zhang Xiao , Sun Zhi Wei , Xiao Jun Ying , Lu Jun Feng , Liu Kun , Xia Bo , Gao Qi , Jia Miao , Xu Cheng Qi , Jiang Yi Na , Zhang Xiao Gang , Tao Kai Shan , Wu Jiang Wei 
Published: March 2024

AbstractLiver injury is a core pathological process in the majority of liver diseases, yet the genetic factors predisposing individuals to its initiation and progression remain poorly understood. Here we show that asialoglycoprotein receptor 1 (ASGR1), a lectin specifically expressed in the liver, is downregulated in patients with liver fibrosis or cirrhosis and male mice with liver injury. ASGR1 deficiency exacerbates while its overexpression mitigates acetaminophen-induced acute and CCl4-induced chronic liver injuries in male mice. Mechanistically, ASGR1 binds to an endoplasmic reticulum stress mediator GP73 and facilitates its lysosomal degradation. ASGR1 depletion increases circulating GP73 levels and promotes the interaction between GP73 and BIP to activate endoplasmic reticulum stress, leading to liver injury. Neutralization of GP73 not only attenuates ASGR1 deficiency-induced liver injuries but also improves survival in mice received a lethal dose of acetaminophen. Collectively, these findings identify ASGR1 as a potential genetic determinant of susceptibility to liver injury and propose it as a therapeutic target for the treatment of liver injury.