bluuebunny/crossref_metadata_2025_split huggingface dataset:
(O-03) DORSAL VENOUS LEAK LIGATION IN PATIENTS WITH ERECTILE DYSFUNCTION. REPORT OF 60 PATIENTS WITH 12-MONTH FOLLOW-UP
Authors: Uribe J F 
Published: March 2024

Abstract

Objective
Penile dorsal venocclusive dysfunction is recognized as a cause of erectile dysfunction in some young patients with no other risk factors. The objective of this study is to report the results of a surgical technique in patients who presented ED before the age of 40, with follow-up up to 12 months after treatment.

Materials and Methods
A descriptive study was carried out in a retrospective cohort of medical records with 60 patients who met the inclusion criteria, evaluated, and underwent standardized ligature surgery by the same surgeon between 01/2014 and 04/2022. The group underwent a symptom score (International Index of Erectile Function-5), before surgery, 3, 6 and 12 months after. The results of the IIFE-5 before and after surgery were related to the different degrees of erectile dysfunction (severe, moderate, and mild); additionally they were divided into three groups according to criteria defined by the IIFE-5 as successful, moderate, and poor. The diagnosis of venous leaks was made by penile Doppler ultrasound, recording venous leaks and degree of penile fibrosis. The study protocol was approved by the Research Committee of the Pablo Tobon Uribe Hospital in Medellín.

Results
The age of onset of erectile dysfunction was between 14-39 years, mean 23.9; the mean age of the patients who consulted was 31.5 years. The time of evolution of the disease before attempting surgery varied between 2 months and 21 years (average 9.5 years). The result of the preoperative IIFE-5 was: Severe ED: n=6 (10%) and moderate ED: n=54 (90%), there were no preoperative mild ones. Postoperative outcomes at 12 months were: moderate ED n=13 (21.6%); mild ED n=25 (41.6%) and without ED n=22 (36.6%), after the intervention. Additionally, according to the internal analysis of IIFE-5: n=39 (65%) was successful; n=9 (15%) moderate and n=12 (20%) poor.

Conclusions
Ligation of penile dorsal venous leaks has good medium and long-term results in terms of erection quality and patient satisfaction.

Financing
No conflicto.
(PM-23) YOGA PRACTICE INTERVENTION AS A COMPLEMENTARY AND INTEGRATIVE TREATMENT FOR COMPULSIVE SEXUAL BEHAVIOR DISORDER: A PILOT STUDY
Authors: Costa E M , Takeda O H , Fernandes R Y , Branco W B C , Cruz MVPd , Guirado A G , Vidal RNdF , Ferreira BdO , Scanavino MdT 
Published: March 2024

Abstract

Objective
Investigate the feasibility of a Yoga Practice intervention (YPI) as an integrative treatment for adult men with compulsive sexual behavior disorder (CSBD) explored through the attendance and adherence treatment protocol, and the functionality of data collection mechanisms.

Methods
For this study, twelve men diagnosed with CSBD and that did not present substance-use, paraphilic, psychotic, current manic or hypomanic, neurocognitive disorders, gender dysphoria, physical limitations, already practiced yoga or started psychotherapy more than six months ago were randomized in a 2-arm, double-blind clinical trial, comparing a Kundalini YPI with a supervised muscle stretching 12-week program. Participants submitted their applications online on baseline, times 1 (4 weeks), 2 (8 weeks) and time 3 (12 weeks) and the proportion of treatment and protocol adherence, teacher adherence, and allocation concealment were estimated.

Results
The age range was 24 to 47 years old. 58% were single or widower, 41% married or common-law; 75% were caucasians and 25% afro-descendants. The minimum schooling was elementary, (50% finished college). Average family income was $ 1130. There was no statistically significant association between sociodemographic and intervention groups. The patient attendance was 58%, patient adherence to the protocol 30%, professors' adherence to the protocol reached 100%, and the allocation concealment for the double-blind method ensured 100%. The answers of the self-responsive online questionnaires on psychopathologic variables reached 87% of the requested answers, and the daily practices at home 45%.

Conclusions
Although the YPI evaluated for CSBD was acceptable and functional, this pilot indicates changes in procedures to improve attendance and adherence of patients.

Financing
No conflict.
More than a photoreceptor: aureochromes are intrinsic to the diatom light-regulated transcriptional network
Authors: Coesel Sacha N 
Published: March 2024

This article comments on:
Im SH, Lepetit B, Mosesso N, Shrestha S, Weiss L, Nymark M, Roellig R, Wilhelm C, Isono E, Kroth PG. 2024. Identification of promoter targets by Aureochrome 1a in the diatom Phaeodactylum tricornutum. Journal of Experimental Botany 75, 1834–1851.
NEATmap: a high-efficiency deep learning approach for whole mouse brain neuronal activity trace mapping
Authors: Zheng Weijie , Mu Huawei , Chen Zhiyi , Liu Jiajun , Xia Debin , Cheng Yuxiao , Jing Qi , Lau Pak-Ming , Tang Jin , Bi Guo-Qiang , Wu Feng , Wang Hao 
Published: March 2024

ABSTRACT
Quantitative analysis of activated neurons in mouse brains by a specific stimulation is usually a primary step to locate the responsive neurons throughout the brain. However, it is challenging to comprehensively and consistently analyze the neuronal activity trace in whole brains of a large cohort of mice from many terabytes of volumetric imaging data. Here, we introduce NEATmap, a deep learning–based high-efficiency, high-precision and user-friendly software for whole-brain neuronal activity trace mapping by automated segmentation and quantitative analysis of immunofluorescence labeled c-Fos+ neurons. We applied NEATmap to study the brain-wide differentiated neuronal activation in response to physical and psychological stressors in cohorts of mice.
A panel discussion on AI for science: the opportunities, challenges and reflections
Authors: Zhao Weijie 
Published: March 2024

ABSTRACT
Artificial intelligence (AI) tools are changing the way we do science. AlphaFold basically solved the conundrum of protein structure prediction; DeepMD greatly improved the efficiency and accuracy of molecular simulations; and the emerging large language models such as ChatGPT are opening up more possibilities for scientific applications. In this panel, five experts from China and the US discussed the concept, development, bottlenecks and opportunities of AI for Science (AI4S), as well as their understanding of the relationship between AI and science.

Roberto Car
Professor at Department of Chemistry, Princeton University, USA

Weinan E
Professor at School of Mathematical Sciences, Peking University, China; AI for Science Institute, Beijing, China

David Srolovitz
Professor at Department of Mechanical Engineering, University of Hong Kong, China

Han Wang
Professor at the Institute of Applied Physics and Computational Mathematics, Chinese Academy of Sciences, China

Linfeng Zhang (Chair)
Chief scientific officer of DP Technology, China; AI for Science Institute, Beijing, China
Structural constraints of pyocin S2 import through the ferripyoverdine receptor FpvAI
Authors: Goult Jonathan D , Van Daniel C L , Taylor Yasmin V , Inns Patrick G , Kaminska Renata , Vesely Martin , Kleanthous Colin , Paci Emanuele 
Published: March 2024

Abstract
TonB-dependent transporters (TBDTs) mediate energized transport of essential nutrients into gram-negative bacteria. TBDTs are increasingly being exploited for the delivery of antibiotics to drug-resistant bacteria. While much is known about ground state complexes of TBDTs, few details have emerged about the transport process itself. In this study, we exploit bacteriocin parasitization of a TBDT to probe the mechanics of transport. Previous work has shown that the N-terminal domain of Pseudomonas aeruginosa–specific bacteriocin pyocin S2 (PyoS2NTD) is imported through the pyoverdine receptor FpvAI. PyoS2NTD transport follows the opening of a proton-motive force-dependent pore through FpvAI and the delivery of its own TonB box that engages TonB. We use molecular models and simulations to formulate a complete translocation pathway for PyoS2NTD that we validate using protein engineering and cytotoxicity measurements. We show that following partial removal of the FpvAI plug domain which occludes the channel, the pyocin's N-terminus enters the channel by electrostatic steering and ratchets to the periplasm. Application of force, mimicking that exerted by TonB, leads to unraveling of PyoS2NTD as it squeezes through the channel. Remarkably, while some parts of PyoS2NTD must unfold, complete unfolding is not required for transport, a result we confirmed by disulfide bond engineering. Moreover, the section of the FpvAI plug that remains embedded in the channel appears to serve as a buttress against which PyoS2NTD is pushed to destabilize the domain. Our study reveals the limits of structural deformation that accompanies import through a TBDT and the role the TBDT itself plays in accommodating transport.
Nonlinear social evolution and the emergence of collective action
Authors: Allen Benjamin , Khwaja Abdur-Rahman , Donahue James L , Kelly Theodore J , Hyacinthe Sasha R , Proulx Jacob , Lattanzio Cassidy , Dementieva Yulia A , Sample Christine 
Published: March 2024

Abstract
Organisms from microbes to humans engage in a variety of social behaviors, which affect fitness in complex, often nonlinear ways. The question of how these behaviors evolve has consequences ranging from antibiotic resistance to human origins. However, evolution with nonlinear social interactions is challenging to model mathematically, especially in combination with spatial, group, and/or kin assortment. We derive a mathematical condition for natural selection with synergistic interactions among any number of individuals. This result applies to populations with arbitrary (but fixed) spatial or network structure, group subdivision, and/or mating patterns. In this condition, nonlinear fitness effects are ascribed to collectives, and weighted by a new measure of collective relatedness. For weak selection, this condition can be systematically evaluated by computing branch lengths of ancestral trees. We apply this condition to pairwise games between diploid relatives, and to dilemmas of collective help or harm among siblings and on spatial networks. Our work provides a rigorous basis for extending the notion of “actor”, in the study of social evolution, from individuals to collectives.
Charged Spherical Solution in Torsion and Matter Coupling Gravity and Influence of Torsion Parameter and Electric Charge on Compact Stars in Lower Mass Gap
Authors: Maurya S K , Errehymy Abdelghani , Mustafa G , Donmez Orhan , Nisar Kottakkaran Sooppy , Abdel-Aty Abdel-Haleem 
Published: March 2024

Abstract
In this study, we explore a new exact solution for a charged spherical model as well as the astrophysical implications of the torsion parameter χ1 and electric charge Q on compact stars in lower mass gaps in the $f(\mathcal {T})$ gravity framework. Commencing with the field equations that describe anisotropic matter distributions, we select a well-behaved ansatz for the radial component of the metric function, along with an appropriate formulation for the electric field. The resulting model undergoes rigorous testing to ensure its qualification as a physically viable compact object within the $f(\mathcal {T})$ gravity background. We extensively investigate two factors: χ1 and Q, carefully analyzing their impacts on the mass, radius, and stability of the star. Our analyses demonstrate that our models exhibit well-behaved behavior, free from singularities, and can successfully explain the existence of a wide range of observed compact objects. These objects have masses ranging from $0.85^{+0.15}_{-0.15}$ to 2.67 M⊙, with the upper value falling within the mass gap regime observed in gravitational events like GW190814. A notable finding of this study has two aspects: we observe significant effects on the maximum mass (Mmax) and the corresponding radii of these objects. Increasing values of χ1 lead to higher Mmax (approximately $2.64^{+0.13}_{-0.14}$) and smaller radii (approximately $10.40^{+0.16}_{-0.60}$), suggesting the possibility of the existence of massive neutron stars within the system. Conversely, increasing values of Q result in a decrease in Mmax (approximately $1.70^{+0.05}_{-0.03}$) and larger radii (approximately $13.71^{+0.19}_{-0.20}$). Furthermore, an intriguing observation arises from comparing the results: for all values of χ1, nonrotating stars possess higher masses compared to slow-rotating stars, whereas this trend is reversed when adjusting Q.
Boundaries and Disgust in The Duchess of Malfi
Authors: Irish Bradley J 
Published: March 2024

Abstract
Developing recent research on emotion in early modern literature, this essay argues that disgust is the primary emotional mode of Webster’s classic tragedy The Duchess of Malfi. According to modern affective science, disgust is the emotion designed to protect the physical body from material contaminants and protect the social body from symbolic contaminants; as such, it is intimately concerned with the preservation of boundaries. I argue that Malfi stages the thematic collapse of key existential boundaries of the human experiences—boundaries of social class, boundaries of kinship, boundaries between species, and boundaries between life and death—and the result is a compensatory atmosphere of disgust that pervades the play.
Antipsychotic Use and Psychiatric Hospitalization in First-Episode Non-affective Psychosis and Cannabis Use Disorder: A Swedish Nationwide Cohort Study
Authors: Denissoff Alexander , Taipale Heidi , Tiihonen Jari , Di Forti Marta , Mittendorfer-Rutz Ellenor , Tanskanen Antti , Mustonen Antti , Niemelä Solja 
Published: March 2024

Abstract

Background and Hypothesis
There is a paucity of research on treatment outcomes of patients with psychosis and cannabis use disorder (CUD). We aimed to compare the effectiveness of antipsychotics in reducing the risk of hospitalization in patients with first-episode psychosis (FEP) and co-occurring CUD.

Study Design
We utilized a nationwide Swedish cohort of patients with longitudinal register data from the year 2006 to 2021. Participants were patients with FEP and co-occurring CUD (n = 1820, 84.73% men, mean age 26.80 years, SD 8.25 years). The main outcome was hospitalization due to psychotic relapse. Hospitalization due to any psychiatric disorder or substance use disorder (SUD) were examined as secondary outcomes. Within-individual Cox regression models were used to study these associations.

Study Results
Use of any antipsychotic was associated with a 33% risk reduction of psychotic relapse (aHR = 0.67; 95% CI 0.60–0.75). Clozapine (0.43; 0.29–0.64), long-acting injectable (LAI) formulations of risperidone (0.40; 0.22–0.71), aripiprazole (0.42; 0.27–0.65), and paliperidone (0.46; 0.30–0.69) were associated with the lowest risk of relapse. The association between the LAI formulation of olanzapine and hospitalization due to psychosis was statistically non-significant (0.61; 0.35–1.05). Clozapine was associated with an 86% risk reduction of hospitalization due to SUD (0.14; 0.05–0.44). Of oral non-clozapine antipsychotics, aripiprazole was associated with the lowest risk of hospitalization due to psychotic relapse (0.61; 0.45–0.83).

Conclusions
These findings support the use of clozapine, LAI formulations of second-generation antipsychotics other than olanzapine, or oral aripiprazole to prevent hospitalization in FEP and co-occurring CUD.
Systematic Review of the Link Between Social Cognition and Suicidal Ideation and Behavior in People With Serious Mental Illness
Authors: Parrish Emma M , Steenkamp Lisa , Chalker Samantha A , Moore Raeanne C , Pinkham Amy , Depp Colin A 
Published: March 2024

Abstract

Background and Hypothesis
People with serious mental illness (SMI; psychotic and affective disorders with psychosis) are at an increased risk of suicide, yet there is limited research on the correlates of suicide in SMI. Social cognitive impairments are common among people with SMI and several studies have examined social cognition and suicidal ideation (SI) and behavior. This systematic review aims to evaluate the links between various domains of social cognition, SI, and suicidal behavior in SMI.

Study Design
Electronic databases (PubMed and PsycInfo) were searched through June 2023. Records obtained through this search (N = 618) were screened by 2 independent reviewers according to inclusion criteria. Relevant data were extracted, and study quality was assessed.

Study Results
Studies (N = 16) from 12 independent samples were included in the systematic review (N = 2631, sample sizes ranged from N = 20 to N = 593). Assessments of social cognition and SI and behavior varied widely between studies. Broadly, effects were mixed. Better emotion recognition of negative affect was linked to SI and a history of suicide attempts, though there is little consistent evidence for the relationship of emotion recognition and SI or behavior. On the other hand, better theory of mind ability was linked to SI and a history of suicide attempts. Furthermore, negative attributional bias was linked to current SI, but not a history of SI or attempt.

Conclusions
This review suggests mixed associations between social cognition, SI, and behavior in SMI. Future research should evaluate additional mediators and moderators of social cognition and suicide, employing prospective designs.
Circadian photoentrainment varies by season and depressed state: associations between light sensitivity and sleep and circadian timing
Authors: Wescott Delainey L , Hasler Brant P , Franzen Peter L , Taylor Maddison L , Klevens Alison M , Gamlin Paul , Siegle Greg J , Roecklein Kathryn A 
Published: March 2024

Abstract

Study Objectives
Altered light sensitivity may be an underlying vulnerability for disrupted circadian photoentrainment. The photic information necessary for circadian photoentrainment is sent to the circadian clock from melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs). The current study tested whether the responsivity of ipRGCs measured using the post-illumination pupil response (PIPR) was associated with circadian phase, sleep timing, and circadian alignment, and if these relationships varied by season or depression severity.

Methods
Adult participants (N = 323, agem = 40.5, agesd = 13.5) with varying depression severity were recruited during the summer (n = 154) and winter (n = 169) months. Light sensitivity was measured using the PIPR. Circadian phase was assessed using Dim Light Melatonin Onset (DLMO) on Friday evenings. Midsleep was measured using actigraphy. Circadian alignment was calculated as the DLMO-midsleep phase angle. Multilevel regression models covaried for age, gender, and time since wake of PIPR assessment.

Results
Greater light sensitivity was associated with later circadian phase in summer but not in winter (β = 0.23; p = 0.03). Greater light sensitivity was associated with shorter DLMO-midsleep phase angles (β = 0.20; p = 0.03) in minimal depression but not in moderate depression (SIGHSAD &lt; 6.6; Johnson-Neyman region of significance).

Conclusions
Light sensitivity measured by the PIPR was associated with circadian phase during the summer but not in winter, suggesting ipRGC functioning in humans may affect circadian entrainment when external zeitgebers are robust. Light sensitivity was associated with circadian alignment only in participants with minimal depression, suggesting circadian photoentrainment, a possible driver of mood, may be decreased in depression year-round, similar to decreased photoentrainment in winter.
Automated detection and classification of polioviruses from nanopore sequencing reads using piranha
Authors: O’Toole Áine , Colquhoun Rachel , Ansley Corey , Troman Catherine , Maloney Daniel , Vance Zoe , Akello Joyce , Bujaki Erika , Majumdar Manasi , Khurshid Adnan , Arshad Yasir , Alam Muhammad Masroor , Martin Javier , Shaw Alexander G , Grassly Nicholas C , Rambaut Andrew 
Published: March 2024

Abstract
Widespread surveillance, rapid detection, and appropriate intervention will be critical for successful eradication of poliovirus. Using deployable next-generation sequencing (NGS) approaches, such as Oxford Nanopore Technologies’ MinION, the time from sample to result can be significantly reduced compared to cell culture and Sanger sequencing. We developed piranha (poliovirus investigation resource automating nanopore haplotype analysis), a ‘sequencing reads-to-report’ solution to aid routine poliovirus testing of both stool and environmental samples and alleviate the bioinformatic bottleneck that often exists for laboratories adopting novel NGS approaches. Piranha can be used for efficient intratypic differentiation of poliovirus serotypes, for classification of Sabin-like polioviruses, and for detection of wild-type and vaccine-derived polioviruses. It produces interactive, distributable reports, as well as summary comma-separated values files and consensus poliovirus FASTA sequences. Piranha optionally provides phylogenetic analysis, with the ability to incorporate a local database, processing from raw sequencing reads to an interactive, annotated phylogeny in a single step. The reports describe each nanopore sequencing run with interpretable plots, enabling researchers to easily detect the presence of poliovirus in samples and quickly disseminate their results. Poliovirus eradication efforts are hindered by the lack of real-time detection and reporting, and piranha can be used to complement direct detection sequencing approaches.