bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of tumour necrosis factor-α receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema
Authors: D'hulst A. I. , Bracke K. R. , Maes T. , De Bleecker J. L. , Pauwels R. A. , Joos G. F. , Brusselle G. G. 
Published: March 2006

Chronic obstructive pulmonary disease (COPD) is characterised by a local pulmonary inflammatory response to respiratory pollutants and by systemic inflammation. Tumour necrosis factor (TNF)-α has been implicated in systemic effects of COPD and operates by binding the p55 (R1) and p75 (R2) TNF-α receptors.To investigate the contribution of each TNF-α receptor in the pathogenesis of COPD, the present study examined the effects of chronic air or cigarette smoke (CS) exposure in TNF-α R1 knockout (KO) mice, TNF-α R2 KO mice and wild type (WT) mice.CS was found to significantly increase the protein levels of soluble TNF-α R1 (by four-fold) and TNF-α R2 (by 10-fold) in the bronchoalveolar lavage of WT mice. After 3 months, CS induced a prominent pulmonary inflammatory cell influx in WT and TNF-α R1 KO mice. In TNF-α R2 KO mice, CS-induced pulmonary inflammation was clearly attenuated. After 6 months, no emphysema was observed in CS-exposed TNF-α R2 KO mice in contrast to WT and TNF-α R1 KO mice. CS-exposed WT and TNF-α R1 KO mice failed to gain weight, whereas the body mass of TNF-α R2 KO mice was not affected.These current findings suggest that both tumour necrosis factor-α receptors contribute to the pathogenesis of chronic obstructive pulmonary disease, but tumour necrosis factor-α receptor-2 is the most active receptor in the development of inflammation, emphysema and systemic weight loss in this murine model of chronic obstructive pulmonary disease.
Socio-economic status is related to incidence of asthma and respiratory symptoms in adults
Authors: Hedlund U. , Eriksson K. , Rönmark E. 
Published: March 2006

The aim of the present study was to assess the association between socio-economic status and impaired respiratory health in a 10-yr follow-up of a population-based postal survey in Northern Sweden.Multiple logistic regression was used to estimate odds ratios in relation to socio-economic class, using age, sex, a family history of asthma, smoking habits, and occupational exposures to dust, gases and fumes as possible confounders.The study comprised 2,341 males and 2,413 females. Cumulative incidences were generally lowest in professionals, including executives and civil servants at intermediate and higher levels, who were chosen as reference group. Manual workers in industry showed a significantly increased risk of developing asthma, recurrent wheeze, attacks of shortness of breath or a combination of the two, and chronic productive cough. Manual workers in service showed a similar pattern for attacks of shortness of breath, recurrent wheeze, or a combination of the two, and chronic productive cough. The corresponding population attributable risks were ∼10%.Low socio-economic status was a risk factor for the development of asthma, symptoms common in asthma and chronic productive cough.
Diagnoses of chronic beryllium disease within cohorts of sarcoidosis patients
Authors: Müller-Quernheim J. , Gaede K. I. , Fireman E. , Zissel G. 
Published: March 2006

An increase in chronic beryllium disease (CBD) has been suggested due to higher industrial use of beryllium alloys. Since occupational CBD is a perfect phenocopy of sarcoidosis, it might be misdiagnosed as sarcoidosis. In the current it was hypothesised that CBD exists in cohorts of sarcoidosis patients.In a prospective case study, sarcoidosis patients were evaluated for potential beryllium exposure. In those patients in whom beryllium exposure was confirmed and beryllium hypersensitivity demonstrated, the diagnosis of sarcoidosis was rejected and corrected to CBD.In 84 patients seen for re-evaluation or making a diagnosis of sarcoidosis, beryllium exposure was recognised and a diagnosis of CBD was made in 34 out of 84 patients. The time lag between clinical diagnosis of sarcoidosis and the final diagnosis of CBD ranged 0–18 yrs (median 3 yrs) and the mean (range) age at time of diagnosis of CBD was 43.9(25–80) yrs. Beryllium-contaminated workplaces causing disease encompassed a wide spectrum of industries and technical trades in which beryllium-exposure is generally not perceived as a health hazard.In conclusion, chronic beryllium disease still belongs to the spectrum of differential diagnoses of granulomatous disorders.
CC chemokine ligand 1 is released into the airways of atopic asthmatics
Authors: Montes-Vizuet R. , Vega-Miranda A. , Valencia-Maqueda E. , Negrete-García M. C. , Velásquez J. R. , Teran L. M. 
Published: March 2006

CC chemokine ligand (CCL)1/I-309 is a potent attractant for T-helper cell type 2 lymphocytes. The present study investigates whether this cytokine is released in the bronchoalveolar fluid (BALF) of asthmatic patients.Measurements of CCL1 using ELISA showed that levels of this cytokine were significantly elevated in BALF from asthmatics compared with normals (median (range) 193 (120–449) pg·mL−1versus30 (21–55) pg·mL−1). Differential cell counts in BALF showed that either lymphocyte or eosinophil numbers were elevated in asthmatic compared with normal subjects (10.8×103·mL−1versus1.0×103·mL−1and 1.7×103·mL−1versus0.2×103·mL−1, respectively). There was a trend towards a significant correlation between CCL1 levels and lymphocyte numbers in BALF. Separation of BALF using sequential CCL1 affinity column and reverse-phase high-performance liquid chromatography allowed detection of biologically active CCL1. Using immunohistochemistry, CCL1 immunoreactivity was localised predominantly to the airway epithelium.Interestingly, there was a significant correlation between CC chemokine ligand 1 levels and epithelial cell numbers in bronchoalveolar lavage fluid and between these cells and lymphocyte numbers. Moreover, interleukin-4, interleukin-13 and interferon-γ stimulated primary bronchial airway epithelial cells to release CC chemokine ligand 1. These findings suggest that CC chemokine ligand 1 may play a role in lymphocyte recruitment in bronchial asthma.
Mesothelioma environment comprises cytokines and T-regulatory cells that suppress immune responses
Authors: Hegmans J. P. J. J. , Hemmes A. , Hammad H. , Boon L. , Hoogsteden H. C. , Lambrecht B. N. 
Published: March 2006

Malignant mesothelioma is a cancer with dismal prognosis. The objective of the present study was to address the role of the immune system, tumour micro-environment and potential immunosuppression in mesothelioma.Expression profiles of 80 cytokines were determined in the supernatant of mesothelioma cell lines and the original patient's pleural effusion. Influx of immune effector cells was detected by immunohistochemistry.Angiogenin, vascular endothelial growth factor, transforming growth factor-β, epithelial neutrophil-activating protein-78 and several other proteins involved in immune suppression, angiogenesis and plasma extravasation could be detected in both supernatant and pleural effusion. Surrounding stroma and/or infiltrating cells were the most likely source of hepatocyte growth factor, macrophage inflammatory protein (MIP)-1δ, MIP-3α, neutrophil-activating peptide-2, and pulmonary and activation-regulated chemokine that can cause leukocyte infiltration and activation. There was a massive influx of CD4+ and CD8+ T-lymphocytes and macrophages, but not of dendritic cells, in human mesothelioma biopsies. It was further demonstrated that human mesothelioma tissue contained significant amounts of Foxp3+CD4+CD25+ regulatory T-cells. When these CD25+ regulatory T-cells were depleted in anin vivomouse model, survival increased.Mesothelioma is infiltrated by immune effector cells but also contains cytokines and regulatory T-cells that suppress an efficient immune response. Immunotherapy of mesothelioma might be more effective when combined with drugs that eliminate or control regulatory T-cells.
Phase I study of docetaxel and topotecan in patients with advanced malignancies
Authors: Dubey Sarita , Hutson Paul , Alberti Dona , Arzoomanian Rhoda , Binger Kim , Volkman Jennifer , Feierabend Chris , Wilding George , Schiller Joan H 
Published: March 2006

Background. Docetaxel and topotecan are drugs with different mechanisms of action and significant activity against various tumour types. Topotecan may influence docetaxel metabolism by inhibiting the CYP3A4 enzyme. We designed a phase I study to evaluate the maximum tolerated dose of this combination and to assess the impact of pharmaco-kinetic interactions of the two drugs on toxicity. Methods. Docetaxel and topotecan were administered intravenously on day 1, and days 1- 5 respectively, using a phase I dose escalation design. Plasma samples were analysed to determine docetaxel and topotecan concentration by HPLC with subsequent pharmacokinetic analysis using NONMEM. Results. Of the 17 patients enrolled in the trial, 11 had grade 3 and 4 neutropenia and 1 had grade 4 thrombocytopenia. Nonhaematological toxicities were less frequent. The maximum tolerated dose for docetaxel and topotecan were 60 mg/m2 on day 1 and 0.75 mg/m2 days 1- 5, respectively. One patient had stable disease. Subjects with grade]3 haematologic toxicity had higher plasma docetaxel or topotecan area under the curve (AUC) (docetaxel 1.0390.11 mg-hr/L versus 0.7390.13 mghr/L; topotecan 65.8914.6 mcg-hr/L versus 41.6913.9 mcg-hr/L). There was no additive effectoftheAUCofthetwodrugsonthe likelihood of grade]3 haematologic toxicity by multiple logistic regression. Conclusion. The dose-limiting toxicity seen with the combination of docetaxel and topotecan was myelosuppression. Future trials will require growth factor support if this combination is pursued.
The Influence of a Noise Barrier on Nuisance Caused by Vibrations
Authors: Ostendorf C. 
Published: March 2006

Since the construction of a noise barrier beside the motorway near their home, a family suffers from nuisance caused by vibration. Prior to the building activities of the noise barrier there had never been a problem with vibration. The family is convinced that the noise barrier in some way introduces or amplifies the vibration caused by traffic using the motorway. In order to find the cause of the vibration and the relevance of the noise barrier, vibration measurements have been done. These measurements show that the traffic using the motorway is indeed the main cause of the vibration in the building. The noise barrier, however/has no influence on the vibrations. The fact that nuisance occurred in the same period as the building activities, is mainly due to the fast decline of the road-surface influenced by the building activities. The measurements also showed that the floor (especially the bedroom floor) reacted very strongly to vibration with a dominant frequency of 17 Hz. To reduce the vibration, it has been advised that the road-surface of the motorway be renewed and the possibility of modifying the floor to reduce the 17Hz resonance be considered.
Prose Styles of Concerned Anthropology
Authors: Schmidt Nancy J. 
Published: March 2006

Adolf F. Bandelier. The Delight Makers. New York: Harcourt Brace Jovanovich, 1971. xxvii. 490 pp. $7.95 (paper) (first published 1890)Gerald D. Berreman. The Politics of Truth. Atlantic Highlands, N.J.: Humanities, 1982 xii. 298 pp. $17.25 (cloth) (first published 1980)Hugh Brody. Maps and Dreams. London: Jill Norman and Hobhouse, 1981. xix. 297 pp. £7.95 (cloth)Paul Record. Tropical Frontier. New York: Knopf, 1969. xiii. 325 pp. (OP)Dan Rose. Energy Transition and the Local Community. Philadelphia: University of Pennsylvania Press, 1981. xx. 189 pp. $21.50 (clot
A World View Without Props; Elder sisters: Learning from black carib women
Authors: Tanner Adrian , Field Karen L. 
Published: March 2006

Richard K. Nelson. Make Prayers to the Raven:. Koyukon View of the Northern Forest. Chicago: University of" Chicago Press, 1983.xvi. 292 pp. S25.OOVirginia Kerns. Woman and the Ancestors: Black Carib Kinship and Ritual. Urbana: University of Illinois, 1983.xv. 229 pp. $19.95 (cloth)
The Higher Thoughts of Sri Lanka: Seeking Purity; Notes From The Underground
Authors: Yalman Nur , Grindal Bruce 
Published: March 2006

Michael Carrithers. The Forest Monks of Sri Lanka: An Anthropological and Historical Study. Delhi: Oxford University Press, 1983‐ xii. 306 pp. $32.50 (cloth).Dan Rose. The Masks. New York: Printed Matter, Inc. n.d. unpaged.
"Kinship/Interpretation/And Culture" in India; The Anthropology of Space; Marxist Perspectives of Peasantry
Authors: Foster Stephen William , Frisbie Charlotte J. , Sandstrom Alan R. 
Published: March 2006

Akos Ostor. Lina Fruzzetti. and Steve Barnett. eds. Concepts of Person, Kinship, Caste and Marriage in India (Harvard Studies in Cultural Anthropology, 5). Cambridge, Mass.: Harvard University Press, 1982. xiv. 271 pages. $35.00 (cloth).Rik Pinxten. Ingrid van Dooren. and Frank Harvey. The Anthropology of Space. Philadelphia: University of Pennsylvania Press, 1983. xi. 240 pp. $32.50 (cloth). Social Anthropology of Peasantry. Joan P. Mencher. ed. Atlantic Highlands, N.J.: Humanities Press, 1983‐ xii. 351pp. $22.50 (cloth).
Victor Turner's Pilgrimage: The Play of Life as Performance of the Sacred; Theatre and Anthropology; Gender, Class, and Self in Norway; The Dehuman Syndrome
Authors: Johnson Norris Brock , Turnbull Colin M. , Field Karen L. , Manson William C. 
Published: March 2006

Victor Turner. From Ritual to Theatre: The Human Seriousness of Play. Performance Studies Series, No. 1. New York: Performing Arts Journal Publications. 1982. 127 pp. $6.95 (paper).Richard Schechner. The End of Humanism: Writings on Performance. Performing Arts Journal Publications, 1982, 128 pp. (paper).Marianne Gullestad. Kitchen‐Table Society. New York: Columbia University Press, 1984. 356pp. $20.00 (paper)Ashley Montagu and Floyd Matson. The Dehumanization of Man. New York: McGraw‐Hill Book Company, 1983. xxxvii. 246 pp. $14.95 (cloth)
Three Studies in Ethnicity and Adaptation
Authors: Ridington Robin 
Published: March 2006

Boehm. Christopher. Montenegrin Social Organization and Values. New York: AMS Press. 1983. + 181 pp. $21.50 (cloth).Chadney. James G. The Sikhs of Vancouver. New York: AMS Press. 1984. vii. 291 pp. $71.50 (cloth).Driben. Paul. We Are the Metis: The Ethnography of. Halfbreed Community in Northern Alberta. New York: AMS Press. 1985. iii. 176 pp. $32.50 (cloth).
Representing Religion in The Postmodern Age
Authors: Stoller Paul 
Published: March 2006

Crocker. Jon Christopher. Vital Souls: Bororo Cosmology, Natural Symbolism and Shamanism. Tuscon: University of Arizona Press, 1985. xiii. 380 pp. $29.95 (cloth).Farella. John R. The Main Stalk:. Synthesis of Navajo Philosophy. Tucson: University of Arizona Press, 1984. + 221 pp. $19.95 (cloth).Angell. J. William. and E. Pendleton Banks. eds. Images of Man: Studies in Religion and Anthropology. Macon, Ga.: Mercer Press, 1984. ix. 142 pp. $13.95 (cloth).
Missionaries, Apologists, and Anthropologists
Authors: Mosko Mark S. 
Published: March 2006

Darrell L. Whiteman, ed. Missionaries, Anthropologists, and Culture Change (Part I.). Studies in Third World Societies, no. 25. Williamsburg, VA: College of William and Mary, 1985. xii plus 424 pp. no price listed (paper).Frank A. Salamone, ed. Anthropologists and Missionaries (Part II). Studies in Third World Societies, no. 26. Williamsburg, VA: College of William and Mary, 1986. vii plus 306 pp. no price listed (paper).
Pursuing Lives and History
Authors: Langness L. L. 
Published: March 2006

Lawrence C. Watson and Maria‐Barbara Watson‐Franke. Interpreting Life Histories. New Brunswick, N.J.: Rutgers University Press, 1985. + 228 pp. $25.00 (cloth).Ronald J. Grele. Envelopes of Sound (second edition). Chicago: Precedent Publishing, Inc., 1985. xii. 283 pp. $20.95 (cloth).Arnold Krupat. For Those Who Come After. Berkeley: University of California Press, 1985. xv. 187 pp. $14.95 (cloth).Henry Munson. Jr. The House of Si Abd Allah. New Haven: Yale University Press, 1984. xvi. 280 pp. $19.95 (cloth).
Poetry and Culture: The "Bottom Line"
Authors: Cervantes Linda LeValley 
Published: March 2006

Lila Abu‐Lughod. Veiled Sentiments: Honor and Poetry in. Bedouin Society. Berkeley and Los Angeles: University of California Press. 1986. xix. 317 pp. $35.00 (cloth); $10.95 (paper).Stanley Diamond. Going West. Northampton: Hermes House Press. 1986. 80 pp. $5.50 (paper).
Inside, Outside African Lives
Authors: Shanklin Eugenia 
Published: March 2006

Marianne Alverson. Under African Sun. Chicago: University of Chicago Press, 1987. xvi. 233 pp. $19.95 (cloth).Francis Mading Deng. The Man Called Deng Majok. New Haven: Yale University Press, 1986. xvi. 294 pp. $26.00 (cloth).Edith Turner. The Spirit and the Drum. Tucson: University of Arizona Press, 1987. xii. 165 pp. $18.95 (cloth).
Ginseng and Aspirin: Health Care Alternatives for Aging Chinese in New York; The Culture of Health: Asian Communities in the United States; Health and Medicine under Capitalism: Korean Immigrants in Australia
Authors: Min Pyong Gap 
Published: March 2006

Ginseng and Aspirin: Health Care Alternatives for Aging Chinese in New York. Zibin Guo. Ithaca, NY: Cornell University Press, 2000. xii. 173 pp.The Culture of Health: Asian Communities in the United States. Grace Xueqin Ma. Westport, CT: Bergin and Garvey, 1999. + 165 pp.Health and Medicine under Capitalism: Korean Immigrants in Australia. Gil Soo Han. Madison, NJ: Fairleigh Dickinson University Press, 2000.292 pp.
The Book Review Section (Commentary, Reviews, Recent Publications)
Authors: Murray Stephen O. , Kennedy Matthew , Grube John , Paloma Luis , Fitzgerald Tom 
Published: March 2006

Life is Hard: Machismo. Danger, and the Intimacy of Power in Nicaragua by Roger N. Lancaster. Berkeley: University of California Press, 1992. 340 pp. $25 hb.Arresting Images: Impolitic Art and Uncivil Actions, by Steven C. Dubin. (New York: Routledge Press 1992). 374 pages.Homosexuality and Male Bonding in Pre‐Nazi Germany, edited and introduced by Harry Oosterhuis. translations by Hubert Kennedy. (Special issue of the Journal of Homosexuality. Volume 22, Numbers 1/2, 1991).Making Trouble: Essays on Gav History. Politics, and the University by John D'Emilio. (New York: Routledge 1992.) 274 pages, $15.95 paperback.Men Who Beat the Men Who Love Them, by David Island & Patrick Letellier. (New York: Harrington Park Press 1991.) 301 pages.
The Book Review Section (Commentary, Reviews, Recent Publications)
Authors: Amory Deb , Page J. Bryan , Brodsky Joel I. , Murray Stephen O. 
Published: March 2006

Chic Thrills:. Fashion Reader, edited by Juliet Ash and Elizabeth Wilson. (Berkeley: University of California Press.) 1992. 250 pages.Hombres Que Aman Hombres (Men Who Love Men) by Jacobo Schifter and Johnny Madrigal Pana.Bearing Witness: Gay Men's Health Crisis and the Politics of AIDS by Philip M. Kayal. Boulder: westview Press. 1993. 275 pp. (paper).
Reviews
Authors: Iianusa‐Cestero Renee , Bolton Ralph 
Published: March 2006

HOMOTEENS, directed by Joan Jubela and Michele Forsten. Jubela Productions, New York, 1993. Distributed by Frameline, 346 9th Street, San Francisco, CA. TEL: 415‐703‐8560, FAX: 415‐861‐1404.Good Sex: Real Stories from Real People, by Julia Hutton. (Pittsburgh: Cleis Press, Inc., 1992). 225 pages, $12.95 paperback.
In VitroAntioxidant andIn VivoPhotoprotective Effects of an Association of Bioflavonoids with Liposoluble Vitamins
Authors: Campos Patrícia M. B. G. Maia , Gianeti Mirela D. , Kanashiro Alexandre , Lucisano‐Valim Yara M. , Gaspar Lorena R. 
Published: March 2006

ABSTRACTA new tendency in cosmetic formulations is the association of botanical extracts and vitamins to improve skin conditions by synergic effects. The objective of this study was to determine the antioxidant activity of associated bioflavonoids, retinyl palmitate (RP), tocopheryl acetate (TA) and ascorbyl tetra‐isopalmitate (ATIP), as well as their photoprotective effects in preventing increased erythema, transepidermal water loss (TEWL) and sunburn cell formation in hairless mouse skin. The antioxidant activity of solutions containing the association or each substance separately was evaluatedin vitroby a chemiluminescence assay. The photoprotective effect was evaluated by means ofin vivotests. Dorsal skin of hairless mice was treated daily by topical applications for 5 days with formulations containing or not containing (vehicle) the flavonoid‐vitamins association (5%). The skin was irradiated (UVA/B) 15 minutes after the last application. The results showed that bioflavonoids hadin vitroantioxidant properties and also that when they were associated with vitamins their antioxidant activity was more pronounced. On the other hand, erythema and UV damage to the permeability barrier function (TEWL) was not significantly reduced by previous treatment with the flavonoid‐vitamin‐association formulations, when compared to the irradiated vehicle‐treated area. However, the treatment protected the skin from UV damage because it reduced the number of sunburn cells, when compared to the vehicle‐treated area. Finally, the association of vitamins and bioflavonoids added to a dermocosmetic formulation showed a relevant biological activity in terms of photoprotection, because the association of bioflavonoids and vitamins acted by different mechanisms, such as antioxidation and absorption of UV radiation, which suggests its use in antiaging and photoprotective products.
Microspectroscopy of the Photosynthetic Compartment of Algae
Authors: Evangelista Valtere , Frassanito Anna Maria , Passarelli Vincenzo , Barsanti Laura , Gualtieri Paolo 
Published: March 2006

ABSTRACTWe performed microspectroscopic evaluation of the pigment composition of the photosynthetic compartments of algae belonging to different taxonomic divisions and higher plants. The feasibility of microspectroscopy for discriminating among species and/or phylogenetic groups was tested on laboratory cultures. Gaussian bands decompositions and a fitting algorithm, together with fourth‐derivative transformation of absorbance spectra, provided a reliable discrimination among chlorophylls a, b and c, phycobiliproteins and carotenoids. Comparative analysis of absorption spectra highlighted the evolutionary grouping of the algae into three main lineages in accordance with the most recent endosymbiotic theories.