bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous glucose monitoring as an objective measure of meal consumption in individuals with binge‐spectrum eating disorders: A proof‐of‐concept study
Authors: Presseller Emily K. , Parker Megan N. , Zhang Fengqing , Manasse Stephanie , Juarascio Adrienne S. 
Published: April 2024

AbstractObjectiveGoing extended periods of time without eating increases risk for binge eating and is a primary target of leading interventions for binge‐spectrum eating disorders (B‐EDs). However, existing treatments for B‐EDs yield insufficient improvements in regular eating and subsequently, binge eating. These unsatisfactory clinical outcomes may result from limitations in assessment and promotion of regular eating in therapy. Detecting the absence of eating using passive sensing may improve clinical outcomes by facilitating more accurate monitoring of eating behaviours and powering just‐in‐time adaptive interventions. We developed an algorithm for detecting meal consumption (and extended periods without eating) using continuous glucose monitor (CGM) data and machine learning.MethodAdults with B‐EDs (N = 22) wore CGMs and reported eating episodes on self‐monitoring surveys for 2 weeks. Random forest models were run on CGM data to distinguish between eating and non‐eating episodes.ResultsThe optimal model distinguished eating and non‐eating episodes with high accuracy (0.82), sensitivity (0.71), and specificity (0.94).ConclusionsThese findings suggest that meal consumption and extended periods without eating can be detected from CGM data with high accuracy among individuals with B‐EDs, which may improve clinical efforts to target dietary restriction and improve the field's understanding of its antecedents and consequences.
Why don't women engage in muscle strength exercise? An integrative review
Authors: Stimson A. M. , Anderson C. , Holt A.‐M. , Henderson A. J. 
Published: April 2024

AbstractIssue AddressedWomen are ‘at‐risk’ population for failing to meet muscle strengthening guidelines. Health benefits specific to this exercise mode include maintenance of muscle mass, which is associated with reduced risk of chronic disease and falls. Of significance is the progressive decline in muscle strength exercise participation in women aged 35–54 in Australia. This period is critical for maintaining muscle strength as it establishes foundations for older women's engagement. This integrative review examined available evidence regarding factors influencing muscle strength exercise participation, specifically in women aged 35–54.MethodsSeven databases were searched. Study inclusion criteria were: (1) peer reviewed, (2) English language, (3) sample populations of healthy female adults or general adult sample population differentiating females from males, (4) mean age between 35 and 54 years, (5) focused on muscle strength exercise and measured as the primary outcome factors of participation in muscle strength exercise.FindingsFive of 1895 studies met inclusion criteria. Five key factors were associated with participation in muscle strength exercise of women aged 35–54 years: perceived time constraints; knowledge and education; modality and intensity; social support and behavioural strategies.ConclusionsFocused education on strength exercise and guidelines, plus initiatives and strategies that suit the needs of this cohort, are necessary to achieve health and wellbeing benefits. Responsive approaches by health professionals to these women's circumstances can potentially address current low participation levels.So What?Creating conditions where health professionals respect a woman's exercise preferences can positively impact these women's musculoskeletal health into older age.
Comparison of Ba‐Hao burn ointment gauze and petrolatum gauze in split graft donor site healing: A randomized, prospective, and self‐control study
Authors: Liu Wen‐Jing , Qian Han‐Ying , Zhang Yuan‐Yuan , Qiu Le , Wang Fei , Chen Xu‐Lin 
Published: April 2024

AbstractBackground and AimsTo assess patient comfort, wound healing, and scarring at the 6‐month follow‐up of split‐skin graft donor sites treated with Ba‐Hao burn ointment (BHBO) gauze, a compound preparation of traditional Chinese medicine since 1970s, compared with petrolatum gauze.MethodsThirty patients admitted to the Department of Burns of the First Affiliated Hospital of Anhui Medical University between September 2021 and September 2022 participated in this randomized, prospective, self‐control clinical study. After harvesting the split skin, donor sites were divided into two parts along the midline. BHBO gauze was applied to half of the donor wounds, and petrolatum gauze was applied to the other half. The wound healing time, pain scores on the postoperative Days 3, 6, and 9, and Vancouver Scar Scale (VSS) score at the 6‐month follow‐up were assessed.ResultsThe wound healing time was significantly shorter in the BHBO group than in the control group (10.07 ± 1.48 days vs. 11.50 ± 1.74 days, p < 0.001). On postoperative Days 3 and 6, the pain scores quantified by visual analog scores were significantly lower in the BHBO group than in the control group (5.33 ± 1.54 and 4.17 ± 1.51, respectively vs. 7.57 ± 1.41 and 5.20 ± 1.47, respectively). The difference in the visual analog scale score on postoperative Day 9 between the groups was not significant (p > 0.05). Microbiological assessment revealed the absence of bacterial contamination in both groups. At the 6‐month follow up, the VSS score was significantly lower in the BHBO group (6.67 ± 1.92) than in the control group (9.57 ± 1.55).ConclusionBHBO resulted in faster donor‐site healing, reduced postoperative pain, and improved scar quality at the 6‐month follow‐up than petrolatum gauze alone.
Assessment of TNF‐α (‐857 C/T) gene polymorphism in oral lichen planus disease: A case–control study
Authors: Marabi Mohammad Hesam , Yari Kheirollah , Mozaffari Hamid Reza , Hatami Masoud 
Published: April 2024

AbstractBackground and aimsOral lichen planus (OLP) is an inflammatory mucocutaneous disorder with an immune‐mediated pathogenesis. The tumor necrosis factor‐α (TNF‐α) level in the serum of OLP patients is significantly higher than in the control group. TNF‐α‐857 C/T polymorphism can be related to the increased TNF‐α level in blood circulation. This study investigated the relationship between TNF‐α (‐857 C/T) polymorphism and OLP patients in an Iranian population.MethodsSaliva samples were taken from 200 people, including 100 patients with OLP and 100 healthy people who did not have significant differences in age and sex. Then, DNA was extracted from them and the TNF‐α (‐857 C/T) genotype was identified using the polymerase chain reaction with confronting two‐pair primers method. Statistical Package for the Social Sciences version 16 software analyzed the results.ResultsThe frequency of C/C, C/T, and T/T genotypes of the TNF‐α‐857 C/T polymorphism in the patient group were 78%, 18%, and 4%, respectively, and in the control group were 72%, 23%, and 5%, respectively. The differences between the two groups regarding allele (χ2  =  0.97, p  = 0.32) and genotype (χ2  =  0.96, p  = 0.62) frequency among the studied population were insignificant.ConclusionThis study showed that the difference in the frequency of single nucleotide polymorphism TNF‐α‐857 C/T polymorphism in the patient and control group had no significant relationship with the increased OLP incidence. Also, no significant association was observed between allele and genotype frequency of TNF‐α (‐857 C/T) with OLP subtypes.
Compound heterozygous mutations in three Chinese patients of Segawa syndrome and their treatment outcomes
Authors: Zhang Jie , Huang Yaxin , Hu Yulei , Bai Bing 
Published: April 2024

AbstractSegawa syndrome is a rare autosomal recessive form of dopa‐responsive dystonia resulting from TH gene dysfunction. Patients typically exhibit symptoms such as generalized dystonia, rigidity, tremors, infantile Parkinsonism, and pseudo‐spastic paraplegia. Levodopa is often an effective treatment. Due to its rarity, high heterogeneity, and poorly understood pathological mutation and phenotype spectrums, as well as genotype–phenotype and genotype‐treatment outcome correlations, Segawa syndrome poses diagnostic and therapeutic challenges. In our study, through clinical and molecular analyses of three Chinese Segawa patients, we re‐evaluated the pathogenicity of a TH mutation (c.880G>C;p.G294R) previously categorized as “Conflicting classifications of pathogenicity” in ClinVar. Also, we summarized the clinical phenotypes of all reported Segawa syndrome cases until 2023 and compared them with our patients. We identified a novel phenotype, “cafe‐au‐lait macules,” not previously observed in Segawa patients. Additionally, we discussed the correlation between specific genotypes and phenotypes, as well as genotypes and treatment outcomes of our three cases. Our findings aim to enhance the understanding of Segawa syndrome, contributing to improved diagnosis and treatment approaches in the future.
Burnout in podiatrists associated with individual characteristics, workplace and job satisfaction: A national survey
Authors: Bonanno Daniel R. , Couch Anna , Haines Terry , Menz Hylton B. , O'Sullivan Belinda G. , Williams Cylie M. 
Published: April 2024

AbstractBackgroundBurnout is highly prevalent among health practitioners. It negatively impacts job performance, patient care, career retention and psychological well‐being. This study aimed to identify factors associated with burnout among Australian podiatrists.MethodsData were collected from registered podiatrists via four online surveys administered annually from 2017 to 2020 as part of the Podiatrists in Australia: Investigating Graduate Employment (PAIGE) study. Information was collected about work history, job preferences, personal characteristics, health, personality, life experiences and risk‐taking behaviours. Multiple logistic regression analyses were used to determine if (i) individual characteristics, (ii) workplace factors and (iii) job satisfaction measures were associated with burnout (based on the abbreviated Maslach Burnout Inventory).ResultsA total of 848 responses were included, with 268 podiatrists (31.6%) experiencing burnout. Participants experiencing burnout were slightly younger, more recent to practice, had poorer health, greater mental distress, lower scores for resilience, extraversion, agreeableness, conscientiousness, emotional stability and openness to experiences. They were less likely to have financial and clinical risk‐taking behaviour and more likely to have career risk‐taking behaviour. Prediction accuracy of these individual characteristic variables for burnout was 72.4%. Participants experiencing burnout were also more likely to work in private practice, have more work locations, work more hours, more direct patient hours, see more patients, have shorter consultation times, more likely to bulk bill chronic disease management plans, have less access to sick leave and professional development and be more likely to intend to leave patient care and the profession within 5 years than participants not experiencing burnout. Prediction accuracy of these workplace‐related variables for burnout was 67.1%. Participants experiencing burnout were less satisfied with their job. Prediction accuracy of these variables for burnout was 78.8%.ConclusionsMany of the factors associated with burnout in Australian podiatrists are modifiable, providing opportunities to implement targeted prevention strategies. The strength of association of these factors indicates high potential for strategies to be successful.
Perceptions of foot health services from the perspective of patients with rheumatoid arthritis in Finland
Authors: Stolt Minna , Hyytiä Sasu , Suhonen Riitta 
Published: April 2024

AbstractBackgroundFoot health services for people with rheumatoid arthritis (RA) are an important part of their comprehensive care. However, little is known about the perceptions of people with RA have about foot health services. This study aimed to explore how people with RA perceive foot health services.MethodsA descriptive cross‐sectional survey design was applied. The electronic survey data were collected in April 2023 from people with RA through a national patients' association (N = 2400, response rate 24%, n = 565). The statistical data were analysed using descriptive statistics and textual data with thematic analysis.ResultsMost of the respondents (n = 322, 59%) had used foot health services provided by chiropodist or podiatrist. Those who had used services were mostly satisfied but considered patient education about foot health insufficient. One third reported no visits to foot health services at all because of personal and health service system‐related factors.ConclusionsThose people with RA who have access to foot health services value and appreciate the services. However, many people with RA do not use foot health services because they perceive availability of such services limited and thus unequal and hard to access. There is a need to develop foot health services for people with RA so that they are easy to access, correspond to their foot health needs and have seamless care paths at different levels of the health care system.
Improvement in aged liver regeneration using cell transplantation with chemically induced liver progenitors
Authors: Matsuguma Kunihito , Hara Takanobu , Miyamoto Daisuke , Soyama Akihiko , Matsushima Hajime , Fukumoto Masayuki , Imamura Hajime , Yamashita Mampei , Adachi Tomohiko , Eguchi Susumu 
Published: April 2024

AbstractBackgroundA decrease in the regenerative capacity of age‐damaged liver tissue has been reported. Liver progenitor cells may play an important role in the regeneration of injured livers. In the present study we aimed to investigate improvements in the regenerative capacity of age‐damaged livers using chemically induced liver progenitors (CLiPs) derived from mature hepatocytes.MethodsOld (>90 weeks) and young (<20 weeks) mice underwent 70% hepatectomy, with or without trans‐splenic CLiP administration. The residual liver/bodyweight (LW/BW) ratio was measured on postoperative days 1 and 7, and changes in liver regeneration and histology were evaluated.ResultsAt 7 days post‐hepatectomy, LW/BW ratios were significantly better in CLiP‐treated old mice than in untreated old mice (p = .02). By contrast, no effect of CLiP transplantation was observed in young mice (p = .62). Immunofluorescence staining of liver tissue after CLiP administration showed an increase in Ki67‐positive cells (p < .01). Flow cytometry analysis of green fluorescent protein‐labeled CLiPs indicated that transplanted CLiPs differentiated into mature hepatocytes and were present in the recipient liver.ConclusionsCLiP transplantation appears to ameliorate the age‐related decline in liver regeneration in mice.
miR‐129‐5p inhibits anchorage‐independent growth through silencing of ACTN1 and the ELK4/c‐FOS axis in HPV‐transformed keratinocytes
Authors: Huseinovic Angelina , Xu Mengfei , Jaspers Annelieke , Bais Brigitte , Steenbergen Renske D. M. 
Published: April 2024

AbstractA persistent infection with human papillomavirus (HPV) can induce precancerous lesions of the cervix that may ultimately develop into cancer. Cervical cancer development has been linked to altered microRNA (miRNA) expression, with miRNAs regulating anchorage‐independent growth being particularly important for the progression of precancerous lesions to cancer. In this study, we set out to identify and validate targets of miR‐129‐5p, a previously identified tumor suppressive miRNA involved in anchorage‐independent growth and HPV‐induced carcinogenesis. We predicted 26 potential miR‐129‐5p targets using online databases, followed by KEGG pathway enrichment analysis. RT‐qPCR and luciferase assays confirmed that 3'UTR regions of six genes (ACTN1, BMPR2, CAMK4, ELK4, EP300, and GNAQ) were targeted by miR‐129‐5p. Expressions of ACTN1, CAMK4, and ELK4 were inversely correlated to miR‐129‐5p expression in HPV‐transformed keratinocytes, and their silencing reduced anchorage‐independent growth. Concordantly, miR‐129‐5p overexpression decreased protein levels of ACTN1, BMPR2, CAMK4 and ELK4 in anchorage‐independent conditions. Additionally, c‐FOS, a downstream target of ELK4, was downregulated upon miR‐129‐5p overexpression, suggesting regulation through the ELK4/c‐FOS axis. ACTN1 and ELK4 expression was also upregulated in high‐grade precancerous lesions and cervical cancers, supporting their clinical relevance. In conclusion, we identified six targets of miR‐129‐5p involved in the regulation of anchorage‐independent growth, with ACTN1, BMPR2, ELK4, EP300, and GNAQ representing novel targets for miR‐129‐5p. For both ACTN1 and ELK4 functional and clinical relevance was confirmed, indicating that miR‐129‐5p‐regulated ACTN1 and ELK4 expression contributes to HPV‐induced carcinogenesis.
Long‐term dynamics of natural killer cells in response to SARS‐CoV‐2 vaccination: Persistently enhanced activity postvaccination
Authors: Mele Dalila , Ottolini Sabrina , Lombardi Andrea , Conteianni Daniela , Bandera Alessandra , Oliviero Barbara , Mantovani Stefania , Cassaniti Irene , Baldanti Fausto , Gori Andrea , Mondelli Mario U. , Varchetta Stefania 
Published: April 2024

AbstractNatural Killer (NK) cells play a significant role in the early defense against virus infections and cancer. Recent studies have demonstrated the involvement of NK cells in both the induction and effector phases of vaccine‐induced immunity in various contexts. However, their role in shaping immune responses following SARS‐CoV‐2 vaccination remains poorly understood. To address this matter, we conducted a comprehensive analysis of NK cell phenotype and function in SARS‐CoV‐2 unexposed individuals who received the BNT162b2 vaccine. We employed a longitudinal study design and utilized a panel of 53 15‐mer overlapping peptides covering the receptor binding domain (RBD) of the SARS‐CoV‐2 Spike protein to assess NK cell function at 0 and 20 days following the first vaccine, and 30 and 240 days following booster. Additionally, we evaluated the levels of total IgG anti‐Spike antibodies and their potential neutralizing ability. Our findings revealed an increased NK cell activity upon re‐exposure to RBD when combined with IL12 and IL18 several months after booster. Concurrently, we observed that the frequencies of NKG2A + NK cells declined over the course of the follow‐up period, while NKG2C increased only in CMV positive subjects. The finding that NK cell functions are inducible 9 months after vaccination upon re‐exposure to RBD and cytokines, sheds light on the role of NK cells in contributing to SARS‐CoV‐2 vaccine‐induced immune protection and pave the way to further studies in the field.
Comparing diagnostic criteria for posttraumatic stress disorder in a diverse sample of trauma‐exposed youth
Authors: Dodd Cody G. , Kirk Claire L. , Rathouz Paul J. , Custer James , Garrett Amy S. , Taylor Leslie , Rousseau Justin F. , Claasen Cynthia , Morgan Myesha M. , Newport D. Jeffrey , Wagner Karen D. , Nemeroff Charles B. 
Published: April 2024

AbstractDivergent conceptualization of posttraumatic stress disorder (PTSD) within the Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM‐5) and International Statistical Classification of Diseases and Related Health Problems (11th ed..; ICD‐11) significantly confounds both research and practice. Using a diverse sample of trauma‐exposed youth (N = 1,542, age range: 8–20 years), we compared these two diagnostic approaches along with an expanded version of the ICD‐11 PTSD criteria that included three additional reexperiencing symptoms (ICD‐11+). Within the sample, PTSD was more prevalent using the DSM‐5 criteria (25.7%) compared to the ICD‐11 criteria (16.0%), with moderate agreement between these diagnostic systems, κ = .57. The inclusion of additional reexperiencing symptoms (i.e., ICD‐11+) reduced this discrepancy in prevalence (24.7%) and increased concordance with DSM‐5 criteria, κ = .73. All three PTSD classification systems exhibited similar comorbidity rates with major depressive episode (MDE) or generalized anxiety disorder (GAD; 78.0%–83.6%). Most youths who met the DSM‐5 PTSD criteria also met the criteria for ICD‐11 PTSD, MDE, or GAD (88.4%), and this proportion increased when applying the ICD‐11+ criteria (95.5%). Symptom‐level analyses identified reexperiencing/intrusions and negative alterations in cognition and mood symptoms as primary sources of discrepancy between the DSM‐5 and ICD‐11 PTSD diagnostic systems. Overall, these results challenge assertions that nonspecific distress and diagnostically overlapping symptoms within DSM‐5 PTSD inflate comorbidity with depressive and anxiety disorders. Further, they support the argument that the DSM‐5 PTSD criteria can be refined and simplified without reducing the overall prevalence of psychiatric diagnoses in youth.
Dynamic interactions and mechanisms between high‐quality urbanization and ecosystem service value in Shandong Province: Trends, coordination, and implications for sustainable development
Authors: Liu Dandan , Ren Qiran 
Published: April 2024

AbstractAn extensive and profound investigation into the dynamic interactions between High‐Quality Urbanization (HQU) and Ecosystem Service Value are of utmost importance for the coordinated development of the region. Diverging from traditional macro‐level analysis, this study is grounded on county‐scale data, measuring HQU and ecosystem service value from a multidimensional perspective. On the basis of the research framework of “phenomena‐relationships‐mechanisms”, we expect to delve deeper into the spatio‐temporal evolutionary characteristics of ecosystem service value and HQU and their integrated interactions. Additionally, we utilize econometric models to rigorously evaluate the impact of HQU on ecosystem service value, with the goal of filling the current research gaps. The research results are as follows: (1) From 2000 to 2020, the ecosystem service value in Shandong Province exhibit an overall decreasing and then increasing trend, and shows a spatial posture of high east and low west. HQU generally maintains a steady upward trend, and its spatio‐temporal evolution has apparent heterogeneity. (2) The Coupled Coordination Degree (CCD) between HQU and ecosystem service value has a gradual rising trend, and there is an increasing level of consistency between them. (3) HQU has a negative effect on ecosystem service value, and the direction and degree of the effect on segmented ecosystem service value types vary greatly. (4) The effect of HQU on ecosystem service value is heterogenous, and the attenuating effect is mainly found in grain‐producing counties, inland counties, and counties with a lower index of high‐quality urbanization. In conclusion, our results are expected to provide targeted recommendations for sustainable development and ecological balance in Shandong Province.