bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood groups and malignant melanoma
Authors: Karakousis C. P. , Evlogimenos E. , Suh O. 
Published: February 2007

AbstractThe charts of 168 patients with malignant melanoma were reviewed with regard to the incidence of the major blood groups. Blood group A was encountered in 39.9%, Group B in 7.7%, Group AB in 3%, and Group O in 49.4%. Although blood group O had a higher frequency compared to that of the general white population of various series, the difference was not significant. Patients with blood group A had a median survival of 67.7 months whereas patients with blood group O had a median survival of 46.6 months (p = 0.04). The improved survival for blood group A remained significant only in female patients, when the sexes were considered separately. However, group A had an incidence of 24% in early Clark's lesions while that incidence in group O was 9.8%. Female patients had longer median survival (86 months) than male patients (44 months).
Peritoneovenous shunt and neoplastic ascites: A 5‐year experience report
Authors: Campioni N. , Lasagni R. Pasquali , Vitucci C. , Filppetti M. , Spagnoli A. , Pompei S. , Romano P. , Pasqualetti A. , Sorvillo G. , Sega F. M. , Manfredi D. 
Published: February 2007

AbstractThe cases of 42 patients with malignant ascites treated with a peritoneal venous shunt over a 5‐year period are reviewed to establish the incidence of surgical and postsurgical complications. Although the yield of malignant cells found in the peripheral blood was increased after shunting, no new hematogenous metastases were observed after the operation. No evidence of disseminated intravascular coagulation was observed after shunt placement. While the shunt effectively relieved the discomfort due to abdominal distention and respiratory impairment, no restoration of cutaneous hypersensitivity was observed in the nine patients, who were anergic prior to surgery. The median survival of patients with breast and gynecological cancer, after surgery, was significantly longer than the survival of patients with primary gastrointestinal neoplasma. In conclusion, peritoneal venous shunt appears to be an effective and safe method to improve the quality of life of patients with malignant ascites.
Inflammatory pseudotumor of the spleen
Authors: Alpern Harlan D. , Olson John E. , Kozak Alan J. 
Published: February 2007

AbstractInflammatory pseudotumor of the spleen, an extremely rare benign inflammatory mass lesion, which clinically and radiologically mimics a neoplasm, is presented. The case is compared to the two cases previously reported in the literature. Possibilities of etiology and pathogenesis are considered.
B16 melanoma in hairless mice: A model for thermographic research
Authors: Jochimsen P. R. , Folk G. E. , Sundell M. , Loh P. M. 
Published: February 2007

AbstractLittle is understood concerning the mechanism of tumor‐induced thermographic abnormalities observed in man. An ideal animal model is lacking. In an effort to create such a model we have worked with hairless mice, subcutaneously inoculated with B16 melanoma cells. This report documents the progress of that work and the subsequent development of a totally satisfactory system for the study of such tumors in a hairless animal.
Carcinoids: The prognostic effect of primary site histologic type variations
Authors: Johnson Lewis A. , Lavin Philip T. , Moertel Charles G. , Weiland Louis H. , Dayal Yogeshwar Y. , Doos Wilhelm G. , Geller Stephen A. , Cooper Harry S. , Masse Serge R. , Engstrom Paul F. 
Published: February 2007

AbstractCarcinoids are histologically classified as insular (A), trabecular (B), glandular (C), undifferentiated (D) or mixed. These have prognostic significance, i.e. Group 1 (most favorable, A+C); 2 (favorable, A, B, A+B); 3 (relatively unfavorable, all non A+C or A+B mixed types); and 4 (unfavorable, C, D). Midgut primaries have a better prognosis than either foregut or hindgut/cloacal primaries. Carcinoids from 114 Eastern Cooperative Oncology Group patients were studied to determine if primary site prognostic differences result from histologic prognostic group occurrence rate differences across primary sites. By primary site the following rates were observed: Foregut: 1 (0%), 2 (79.2%), 3 (12.5%), 4 (8.3%); midgut: 1 (26.7%), 2(58.7%), 3 (6.6%), 4 (8.0%); hindgut/cloaca: 1 (0%), 2 (42.9%), 3 (42.9%), 4 (14.2%); nongut: 1 (0%), 2 (75.0%), 3 (12.5%), 4 (12.5%), p < 0.01. The results demonstrate that primary site prognostic differences are highly dependent upon histologic prognostic group occurrence rate variations across primary sites. In addition multivariate analysis of survivorship by both histologic type (p < 0.05) and primary site (p < 0.05) demonstrated that each variable has independent prognostic significance.
Carcinoma of the prostate with brain metastasis
Authors: Chung Tae Soo , Thannikkary C. 
Published: February 2007

AbstractBrain metastasis from prostatic carcinoma is considered rare and usually is diagnosed at postmortem examination. The authors reviewed the tumor registry of 1314 patients with proven diagnosis of prostatic carcinoma seen at Hines VA Hospital from January 1963 to December 1978 and found that 8 of the 1314 patients (0.6%) had brain metastasis. Six of eight patients (75%) were diagnosed having brain metastasis at premortem and of these, two patients presented with brain metastasis before diagnosis of prostatic carcinoma was made. Two of four patients who received palliative whole brain irradiation survived more than 1.5 years. It is our belief that patients with prostatic carcinoma who have symptoms of brain metastasis should be worked up and given palliative whole brain irradiation.
Postoperative active specific immunotherapy with supportive measures in patients suffering from recurrent metastasized melanoma: Case reports of six patients
Authors: Tallberg T. , Kalima T. , Halttunen P. , Tykkä H. , Mahlberg K. , Matous B. , Sundell B. 
Published: February 2007

AbstractThe clinical results from postoperative active specific immunotherapy using autologous polymerized tumor material in six patients suffering from metastasized melanoma is reported. Correction of an alleged systemic deficiency leading to malignant cell transformation was attempted by administrating certain essential trace elements, amino acids, vitamins, and a diet containing lipids, extracted from the mammalian central nervous system, after heating. Vaccinations against influenza were also given as a precaution against certain viral infections sometimes seen to precede melanoma recurrence. The clinical results with this postoperative adjuvant therapy are so encouraging that we suggest that sterile tumor tissue should be saved at operation and treated to produce insoluble particles as an option for postoperative treatment of patients suffering from metastasized melanoma. Prospective randomized studies are indicated.
Thymic hyperplasia masquerading as recurrent Hodgkin's disease: Case report and review of the literature
Authors: Edincton Howard , Salwitz James , Longo Dan L. , Roth Jack A. , Pass Harvey 
Published: February 2007

AbstractWhile the appearance of a mediastinal mass in a patient in remission from Hodgkin's disease frequently indicates recurrence, a number of benign processes may present in a similar manner. Tissue confirmation of relapse should be obtained prior to initiating further chemotherapy to avoid the morbidity of unnecessary treatment. We present a case of thymic hyperplasia that developed in a patient previously treated for Hodgkin's disease. Thymic hyperplasia is a poorly understood, apparently benign process that may be confused with recurrent lymphoma. Total excision of such a mass is recommended to rule out coexistent malignancy.
Pathogenesis and characteristics of spontaneously metastasizing mammary carcinomas and the general principle of metastasis
Authors: Kim Untae 
Published: February 2007

AbstractChemical mammary carcinogenesis in immunologically attennuated W/Fu female rats, subjected to specific and nonspecific immunostimulations, yielded many spontaneously metastasizing adenocarcinomas with varying degrees of glandular differentiation, and growth rates. The pathogenesis of these tumors suggested that while carcinogens transform target cells, the host immune system endows them with metastatic potential. The metastatic pathways were recognizable as hematogenous, lymphogenous, or hematogenous‐lymphogenous combined, according to the capacity of the tumor cells to intravasate the lymphatic and/or vascular channel and traverse the pulmonary artery. The same metastatic pattern can be reproduced with cells from any of the organs involved, indicating that it is inherent in all cells within a given tumor, rather than being determined by the organs they colonize. The biological, biochemical and Immunological characteristics of these tumors resemble human breast cancer ihus becoming an effective tool in the formulation of the general principle of metastasis by malignant solid tumors.
Giant leiomyoma of esophagus
Authors: Kramer Marshall D. , Gibb S. Peter , Ellis F. Henry 
Published: February 2007

AbstractThis case report of a 37‐year‐old man with giant leiomyoma details some of the problems encountered in diagnosing and treating this rare form of the disease. Initial studies at another institution were interpreted as demonstrating achalasia, and thoracotomy was later undertaken because of a mistaken diagnosis of a pericardiac mass, which led to a biopsy and a resulting esophagopleural fistula. Subsequent esophagectomy and drainage of empyema space were employed to remove the tumor, which had ulcerated and bled, as well as to drain the empyema cavity. The tumor measured 20.5 cm long and weighed 540 gm. Gastrointestinal continuity was reestablished by colon interposition, and the patient has been well for the succeeding 6 years.
Fatal metastatic cystosarcoma phyllodes in an adolescent female: Case report and review of treatment approaches
Authors: Turalba Cornelius I. C. , El‐Mahdi Anas M. , Ladaga Leopoldo 
Published: February 2007

AbstractThe third reported case of fatal malignant cystosarcoma phyllodes in an adolescent female is described. The patterns of local recurrence and distant spread in this case, including the response to treatment, were similar to those reported in the first reported case in this age group. A review of the treatment recommendations for cystosarcoma phyllodes revealed that the surgical procedure of choice for the malignant variant has remained controversial, and the conclusions regarding the ineffectiveness of radiation and chemotherapy have been based on insufficient data handed down through the years. Our observations in this case and the information we have obtained from the literature have prompted us to recommend a multidisciplinary approach for malignant cystosarcoma phyllodes, particularly in young women, and we are calling for a multi‐institutional study group to further investigate this disease.
Home parenteral nutrition for patients with advanced intraperitoneal cancers and gastrointestinal dysfunction
Authors: Moley Jeffrey F. , August David , Norton Jeffrey A. , Sugarbaker Paul H. 
Published: February 2007

AbstractThe use of total parenteral nutrition (TPN) in patients with advanced, unbeatable cancer is controversial. Occasionally, however, damage to bowel by tumor, radiation, or surgery renders these patients unable to eat and TPN may be indicated to prevent premature death from starvation. We have used Home Parenteral Nutrition (HPN) to support three patients with advanced, unbeatable abdominal cancer and inability to eat. Morbidity was minimal and survival times were 24, 6 and 1.5 months. Payment was covered by third party agencies. All patients and their families were gratified by the ability to return home with nutritional support. HPN can be used to support terminal cancer patients with bowel obstruction and may afford them longer survival. Ideally, patients considered for this should be well motivated, with good support systems, and with survival estimated to be at least months.
Palliative telecobalt—60 with concentrated dose in TNM classification T4 of the breast
Authors: Patricio M. B. , Brites C. F. , Guimaraes M. F. , De Jesus E. B. , Catita J. I. , Vilhena M. 
Published: February 2007

AbstractA method is presented of rapid, palliative radiotherapy for carcinoma of the breast, composed of two sessions of 6.5 or 8.5 Gy delivered at a 48‐hour interval. The radiobiological equivalence of this unconventional technique is presented. Our preliminary results in a series of 80 patients were published in 1978. The present report is based on the analysis of 112 patients with T4 of the breast submitted to the “flash” dose, from March 1978 to December 1981. The method was used not only for relief of symptoms such as pain and hemorrhage, but also as part of intensive radiotherapy in all patients with good response and with no manifestation of distant dissemination so that they were able to resume treatment 2.5 or 3 weeks later, with conventional fractionation. Some of these patients became operable. About half of the cases had castration and/or hormone. therapy and/or chemotherapy. In the group of patients with T4M0, 59.8% were alive after more than 1 year, and of them, 43.7% had no evidence of disease. These encouraging results suggest that this method be advocated in T4 of the breast because of its rapidity and good tolerance with no significant complications.
Primary carcinoma of the fallopian tube in an adolescent
Authors: Gatto Vincent , Selim Mostafa A. , Lankerani Mohammad 
Published: February 2007

AbstractOnly three cases of adenocarcinoma of the fallopian tube in an adolescent have been reported previously in the literature, and we report the fourth such case. The main presenting symptom in those patients was lower abdominal pain. Type of therapy and outcome of these four cases is reviewed. The small number of patients precludes definitive conclusion on optimal therapy. For this reason, we urge continued reporting of cases to insure the formation of concrete therapeutic recommendations.
One‐stage plastic reconstruction of a totally amputated cancerous penis using a unilateral myocutaneous gracilis flap
Authors: Hanash Kamal A. , Tur Juan J. 
Published: February 2007

AbstractA 36‐year‐old Saudi underwent a total penectomy for cancer involving the penile shaft with no corporeal invasion or distant metastases. One year postoperatively and in the absence of tumor recurrence or metastasis, a penile reconstruction using a right myocutaneous gracilis flap was performed. The result two years later was satisfactory, with preservation of deep penile sensation and successful weekly sexual intercourse. To our knowledge, no similar case has been reported previously.
Postchemotherapy esophagitis: The endoscopic diagnosis and its impact on survival
Authors: Auguste Louis Joseph , Nava Hector 
Published: February 2007

AbstractEighteen cancer patients receiving intensive chemotherapy developed leukopenia, fever, dysphagia, and oropharyngeal soreness. Superficial esophageal ulceration suggestive of esophagitis was demonstrated by radiographic examination in 33% of the patients (5/15). Upper gastrointestinal endoscopy revealed superficial ulceration and white mucosal patches in all patients. There was no morbidity associated with the endoscopic procedures. Sixty‐one percent of the patients (11/18) had monilia albicans cultured from the oropharyngeal cavity, and 50% (9/18) had monilia cultured from the esophageal lesions. The evolution of the esophagitis correlated well with the survival of the patients. The monilial esophagitis persisted in six patients who all died within 24 days of systemic moniliasis. After initial improvement five additional patients succumbed; three of them from severe fungal infection. There was resolution of the esophagitis in the remaining seven patients who survived longer. However, two of them had recurrent monilial esophagitis and succumbed to systemic candidiasis. The other five have remained free of esophagitis, their underlying malignancies have remained under control, and so far they have survived an average of one and a half years.Endoscopy is more accurate than radiography in detecting postchemotherapy esophagitis. This complication can be fatal, since it is often followed by systemic candidiasis.
Primary teratocarcinoma of the lung
Authors: Stair J. Michael , Stevenson D. Richard , Schaefer Robert F. , Fullenwider John P. , Campbell Gilbert S. 
Published: February 2007

AbstractPresented is the ninth reported case of teratocarcinoma arising from the parenchyma of the lung. Treatment should include wide surgical resection and adjuvant chemotherapy. Postoperative radiation therapy should be utilized if there is residual disease or nodal metastasis. Preoperative radiation therapy should be considered if there is evidence of chest wall involvement.
An alternative method for repair of a leaking arterial chemotherapy infusion catheter
Authors: Burkhalter James L , Morano James U. 
Published: February 2007

AbstractRegional chemotherapy infusion via selective arterial catheterization is frequently complicated by the development of cracks or leaks within the catheter. This frequently necessitates a catheter exchange. Herein, we report an alternative, simpler method for dealing with a defect within an infusion catheter.
Primary leiomyosarcoma of the inferior vena cava: A case report and review of the literature
Authors: Griffin Andrew S. , Sterchi J. Michael 
Published: February 2007

AbstractSixty‐six cases of leiomyosarcoma of the inferior vena cava (TVC) have been reported. We present another case and review the characteristics and treatment of this rare tumor. IVC leiomyosarcomas spread by extension into adjacent tissue planes. Direct extension into the heart is known, but not into the kidneys, adrenals, or bowel. IVC leiomyosarcomas arising below the renal vein cause pain in the right‐lower quadrant, back, and flank, and varying degrees of lower extremity edema; those arising in the middle caval segment cause right‐upper‐quadrant pain and sometimes renovascular hypertension; those arising above the hepatic vein cause varying manifestations of the Budd‐Chiari syndrome. A reasonable approach to early diagnosis involves oral and intravenous contrast studies followed by computed tomography, angiography, and vena cavography. Aggressive surgical treatment is optimal in light of the tumor's slow growth pattern and relatively low malignant potential. (Metastases have been reported in fewer than 50% of cases.) Tumors involving the lower IVC are most amenable to surgery; extensive collateral venous drainage of the left kidney preserves renal function during resection of middle caval tumors. Upper caval leiomyosarcomas are the least amenable to complete removal. Postoperative survival of all patients has ranged from a few weeks to eight years.
Primary malignant melanoma of the lung
Authors: Alghanem A. A. , Mehan J. , Hassan A. A. 
Published: February 2007

AbstractA case of primary malignant melanoma of the lung in a 42‐year‐old white female is presented. A 6 cm localized mass in the left lower pulmonary lobe was discovered on a thoracic spine X‐ray done for unrelated chronic back pain. The patient underwent left lower lobectomy for cure. Multiple detailed physical examinations did not disclose any primary lesions. Other cases from the English literature are reviewed briefly.
Changes in survival with clinical stage I malignant melanoma
Authors: Karakousis C. P. , Kachrimanidis S. , Rao U. , Emrich L. J. 
Published: February 2007

AbstractInclusion of patients referred to our cancer center following recurrence, by retracing the history and characteristics of these patients back to when they were in stage I, produced a bias that lowered the estimated disease‐free survival rates. However, taking into consideration only patients referred and managed in our center when they had clinical stage I melanoma, significant differences in disease‐free survival over time were revealed <P = 0.03). Thus, the estimated five‐year disease‐free survival rate for 86 patients treated in the period 1971‐75 was 65%, whereas that from 115 patients treated in the period 1976‐80 was 81%. There was no significant increase in disease‐free survival for patients who had an elective node dissection in addition to wide excision.
Intracaval extension of pheochromocytoma simulating pulmonary embolism
Authors: Dicke Timothy E. , Henry Mitchell L , Minton John P. 
Published: February 2007

AbstractPheochromocytoma, a chromaffin tumor of the sympathoadrenal nervous system, rarely exhibits direct extension into the inferior vena cava. We report a patient with a right adrenal pheochromocytoma that caused symptoms of recurrent pulmonary emboli. Intracaval extension of the tumor was detected during investigations for the source of the emboli by abdominal CT scan, ultrasonography, and venocavagraphy. The biochemical diagnosis of pheochromocytoma was confirmed by sharply elevated catecholamine, metanephrine, and VMA urinary levels, which returned to normal upon resection of the rumor. The patient had no evidence of metastatic disease.
Response of advanced breast cancer to total endocrine ablation after exacerbation on tamoxifen: Results in seven patients and possible mechanism of action
Authors: Hartley Jack W. , Wong Jan , Fletcher William S. 
Published: February 2007

AbstractUsage of tamoxifen in the treatment of advanced breast cancer is increasing and is advocated by some authors as primary therapy in all estrogen receptor positive cancer patients. Tamoxifen is an incomplete estrogen antagonist with partial estrogen agonist activity as well. Tamoxifen‐in‐duced exacerbation of breast cancer (“tamoxifen flare”) is reported to occur in 4‐20% or more of treated patients. Management of this condition has varied from stopping treatment to continued administration or reinstitution of tamoxifen after flare symptoms subside. Responses have occurred in some patients so treated, although the remissions do not appear durable. The seven patients with advanced breast cancer in this report experienced disease exacerbation with tamoxifen therapy. Endocrine ablation afforded all patients excellent pain relief and disease control with prolonged survival in six of the seven. There have been no studies directly examining the disease course in flare patients continuing on tamoxifen. Persistence in treating these patients with an incomplete antagonist‐agonist may deprive them of full survival benefit possible through ablative procedures when used in sequential treatment.
Granulomatous reactions in mycosis fungoides
Authors: Dabski Krzysztof , Stoll Howard L. 
Published: February 2007

AbstractGranulomatous reaction characterized by the formation of noncaseating accumulations of epithelioid histiocytes and multinucleated giant cells of the foreign‐body type is a rare, poorly understood, and generally ignored phenomenon seen in various types of lymphoma. Its presence in cutaneous infiltrates of mycosis fungoides is equally unusual, but some favorable prognostic significance has been ascribed to it previously. In this paper, four patients with typical mycosis fungoides and granulomas demonstrated histologically in their cutaneous infiltrates are presented. All four died of disseminated disease with evidence of central nervous system involvement in three of them. These clinical histories lend no support to the notion that granulomatous mycosis fungoides is a benign variant of this lymphoma. Relevant literature is reviewed and discussed.