bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel glycosylated carboranylquinazolines for boron neutron capture therapy of tumors: synthesis, characterization, and in vitro toxicity studies
Authors: Genady Afaf R. , El‐Zaria Mohamed E. 
Published: March 2008

AbstractThe synthesis of a series of N‐glycosyl caboranylquinazolines is described. The condensation reaction of nitro‐acetylanthranilic acid with aminophenylcarborane gave 3‐[(o‐carboran‐1‐yl)phenyl]‐2‐methyl‐6‐nitroquinazolin‐4(3H)‐one 1 followed by reduction with Na2S to the corresponding 6‐amino‐3‐[(o‐carboran‐1‐yl)phenyl]‐2‐methylquinazolin‐4(3H)‐one 2. Reaction of compound 2 with D‐glucose or D‐ribose in methanol in the presence of a catalytic amount of acetic acid affords boronated N‐glycosylaminoquinazolines namely: 2‐methyl‐3‐[4‐(o‐carboran‐1‐yl)phenyl]‐6‐[N‐β‐D‐glucopyranosyl)]aminoquinazolin‐4(3H)‐one 3 or 2‐methyl‐3‐[4‐(o‐carboran‐1‐yl)phenyl]‐6‐[N‐β‐D‐ribofuranosyl)]aminoquinazolin‐4(3H)‐one 4, respectively. Degradation of the o‐caborane cage of compounds 3 and 4 yielded highly water‐soluble compounds of sodium 2‐methyl‐3‐[4‐(nido‐undecarborate‐1‐yl)phenyl]‐6‐[N‐β‐D‐glucopyranosyl]aminoquinazolin‐4(3H)‐one 5 and sodium 2‐methyl‐3‐[4‐(nido‐undecarborate‐1‐yl)phenyl]‐6‐[N‐β‐D‐ribofuranosyl)]aminoquinazolin‐4(3H)‐one 6, respectively. The structures were established on the basis of elemental analysis, NMR, IR and mass spectrometry. The in vitro toxicity test using B16 melanoma cells showed that N‐glycosyl of nido‐undecaboranylquinazolines (5 and 6), with higher water solubility, is not toxic at boron concentration of 3000 µg boron ml−1, whereas, N‐glycosyl of closo‐carboranylquinazolines (3 and 4) has LD50 > 200 µg boron ml−1. The compounds described here may be considered as potential agents for BNCT. Copyright © 2008 John Wiley & Sons, Ltd.
Synthesis and biological activities of new 1H‐1,2,4‐triazole alcohol derivatives containing a ferrocenyl moiety
Authors: Liu Jianbing , Li Lichun , Dai Hong , Fang Jianxin 
Published: March 2008

AbstractFourteen new 1H‐1,2,4‐triazole alcohol derivatives containing a ferrocenyl moiety were synthesized. In addition, six unexpected compounds, the hydroxyls of the title compounds, methylated by methanol, were obtained. The structures of all these new compounds were confirmed using 1H NMR spectra, 13C NMR, MS and elemental analyses. Some compounds were also confirmed with IR spectra. The antifungal and plant growth regulatory activities of the title compounds are discussed. Copyright © 2008 John Wiley & Sons, Ltd.
Synthesis and characterization of an amphiphilic graft copolymer with a poly(acrylic acid) backbone and n‐octylphenyl polyoxyethylene side chains
Authors: Wang F. P. , Du X. Z. , Wang C. , Dong X. L. , Yuan L. 
Published: March 2008

AbstractA novel, well‐defined, amphiphilic graft copolymer was synthesized by the free‐radical copolymerization of acrylic acid and an amphiphilic macromonomer, n‐octylphenyl polyoxyethylene acrylate. This acrylic copolymer was characterized by IR and 1H‐NMR. The number‐average molecular weight was determined by gel permeation chromatography to be 4.37 × 104 (weight‐average molecular weight/number‐average molecular weight = 1.23). The graft copolymer exhibited good solubility in water and high surface activity at much lower concentrations. The molecules of the AA–C8PhEO10Ac copolymer formed polymolecular micelles at 3.0 × 10−4 g/mL. The aggregation of the copolymer was examined in aqueous solution by measurement of the fluorescence of 2‐p‐ toluidinylnaphthalene 6‐sulfonate as a fluorescent probe. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Effects of operation conditions, solvent and gelation bath on morphology and performance of PPESK asymmetric ultrafiltration membrane
Authors: Sun Weina , Li Lei , Chen Cuixian , Li Jiding 
Published: March 2008

AbstractThe effect of gelation temperature, evaporation time, solvent and gelation bath on the structure and performance of poly(phthalazinone ether sulfone ketone) (PPESK) asymmetric ultrafiltration membrane via phase inversion are investigated; the relationship between gelation thickness of dope solutions (X) and time for several polymer solutions with different solvents and gelation bath by online optical microscope–CCD camera experimental system (OM–CC system) are obtained. The results show that gelation temperature has much stronger influence on aperture opening ratio of membrane surface (AOR) and average diameter of membrane surface (AD) than evaporation time, whereas evaporation time has greater effect on the structure factor of membrane cross‐section (S). Bovine serum albumin rejection (R) is mainly determined by surface structure; however, pure water flux (J) is controlled not only by the structure of surface and cross‐section, but also the connectivity of the pores. PPESK membranes with fine performance can be fabricated under appropriate gelation temperature and evaporation time. In addition, the membrane structure and performance vary widely when various solvents and gelation bath are employed. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Atom transfer radical polymerization of methyl methacrylate in a novel ionic liquid and recycling of the catalyst
Authors: Xiao Guilin , Zhang Haibo , Hong Xinlin , Zhang Gaoyong , Zhou Xiaohai , Xia Bilai 
Published: March 2008

AbstractWith 2,2′‐bipyridine as the ligand and methyl 2‐bromopropionate as the initiator, the copper‐mediated atom transfer radical polymerization of methyl methacrylate was first conducted in a novel ionic liquid, N‐butyl‐N‐methyl morpholinium tetrafluoroborate. The polymerization kinetics were confirmed to agree with the features of living/controlled free‐radical polymerization. The results showed that the dosage of catalyst for well‐controlled polymerization could be reduced obviously in N‐butyl‐N‐methyl morpholinium tetrafluoroborate versus the normal organic solvent. The obtained polymers could be separated easily from the catalyst solution in the ionic liquid. Significantly, the recycled N‐butyl‐N‐methyl morpholinium tetrafluoroborate solution of catalysts had catalytic activity similar to that of the fresh catalyst. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Magnetic composite based on vinylic template
Authors: Tudorachi N. , Chiriac A. P. 
Published: March 2008

AbstractThis article presents the achievement of a magnetic composite having a vinylic polymeric structure as matrix based on a styrene/methyl methacrylate/2,3‐epoxypropyl methacrylate. The synthesis of the copolymers performed through an emulsion polymerization process was realized in the presence of potassium persulfate as radical initiator and sodium lauryl sulfate as anionic tensioactive agent. To have a network capable for a better coupling of the ferrite, the vinylic polymeric structure was crosslinked with a diamino‐compound. The magnetic composite obtainment was confirmed by the IR, DSC, and thermogravimetric analysis, as well as by optic and electronic microscopy, and also by the determination of the magnetic susceptibility of the products. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Mit Schrauben Bewehren
Authors: Trautz Martin , Koj Christoph 
Published: March 2008

AbstractSelbstbohrende Vollgewindeschrauben (VGS) sind moderne Verbindungsmittel des Holzbaus, die aufgrund ihrer hohen Festigkeit und ihrer günstigen Verbundeigenschaften zunehmend als Verstärkungselemente oder als Verbindungsmittel für Fügungen von Holzbauteilen zum Einsatz kommen. Um die konstruktiven Vorzüge, die vergleichbar mit den Eigenschaften einer Bewehrung im Stahlbetonbau sind, systematisch zu nutzen, wurden Bauteile aus Brettschichtholz mit Schrauben verstärkt, deren Konfiguration u.a. mit Hilfe von Fachwerkmodellen auf den inneren Kräfteverlauf abgestimmt waren.Im Rahmen von Sondierungsversuchen an Serien gleich bewehrter Bauteile wurden die Veränderungen und Verbesserungen des Tragverhaltens der auf diese Weise verstärkten Bauteile untersucht.
Rapid Cooling Experiments and Use of an Anionic Nuclear Probe to Sense the Spin Transition of the 1D Coordination Polymers [Fe(NH2trz)3]SnF6⋅n H2O (NH2trz=4‐amino‐1,2,4‐triazole)
Authors: Garcia Yann , Ksenofontov Vadim , Mentior Sophie , Dîrtu Marinela M. , Gieck Christine , Bhatthacharjee Ashis , Gütlich Philipp 
Published: March 2008

Abstract[Fe(NH2trz)3]SnF6⋅n H2O (NH2trz=4‐amino‐1,2,4‐triazole; n=1 (1), n=0.5 (2)) are new 1D spin‐crossover coordination polymers. Compound 2 exhibits an incomplete spin transition centred at around 210 K with a thermal hysteresis loop approximately 16 K wide. The spin transition of 2 was detected by the Mössbauer resonance of the 119Sn atom in the SnF62− anion primarily on the basis of the evolution of its local distortion. Rapid‐cooling 57Fe Mössbauer and superconducting quantum interference device experiments allow dramatic widening of the hysteresis width of 2 from 16 K up to 82 K and also shift the spin‐transition curve into the room temperature region. This unusual behaviour of quenched samples on warming is attributed to activation of the molecular motion of the anions from a frozen distorted form towards a regular form at temperatures well above approximately 210 K. Potential applications of this new family of materials are discussed.
Thermolysis Product Distribution of Solid Waste Obtained From Olive Oil Production
Authors: Mehmetli Ebru , Dogan Özgür , Tiris Mustafa , Kiran Nilgün Ciliz , Matuschek Georg 
Published: March 2008

AbstractPyrolysis and direct combustion processes were applied to pomace obtained from olive oil production in Bayer/ICI/Shell (BIS) and Verbant der Chemische Industrie (VCI) furnaces. The volatile and semi‐volatile products derived from both processes taking place in each furnace were captured on XAD resins at selected temperature and non‐volatiles were obtained after extraction of the resins with acetone. The qualitative and quantitative determinations were carried out by using a gas chromatograph coupled with mass spectrometry. It was found that the compound distribution at different temperatures in the combustion process were wider than for the pyrolysis in the BIS furnace. The compounds obtained at lower temperatures during pyrolysis and combustion in the VCI furnace showed similarities, although a larger number of compounds were obtained at 800°C in the combustion process than in the pyrolysis process.
Pilot study of combination chemotherapy of S‐1, a novel oral DPD inhibitor, and interferon‐α for advanced hepatocellular carcinoma with extrahepatic metastasis
Authors: Nakamura Masato , Nagano Hiroaki , Marubashi Shigeru , Miyamoto Atsushi , Takeda Yutaka , Kobayashi Shogo , Wada Hiroshi , Noda Takehiro , Dono Keizo , Umeshita Koji , Monden Morito 
Published: March 2008

AbstractBACKGROUND.To the authors' knowledge, there is no effective therapy for extrahepatic metastasis of hepatocellular carcinoma (HCC). In a pilot study, the results of combination therapy of S‐1, a novel oral dehydropyrimidine dehydrogenase (DPD) inhibitor, and interferon‐alpha (IFN‐α) are reported for HCC patients with extrahepatic metastasis.METHODS.Twelve patients with extrahepatic metastasis of HCC were enrolled in the pilot study. S‐1 was administered orally at a dose based on body surface area, twice daily after a meal, for 4 weeks. IFN‐α was injected subcutaneously on Days 1, 3, and 5 of each week. One course consisted of consecutive administration for 28 days followed by 14 days rest.RESULTS.An objective response was observed in 3 (25%) of 12 patients. The overall 1‐year survival rate was 61.7%. Grade 3 leukocytopenia was observed in 1 patient (8.3%). No severe toxicity or treatment‐related deaths were observed.CONCLUSIONS.The combination therapy of S‐1 and IFN‐α appears to be highly efficacious, with low toxicity in patients with extrahepatic metastases of HCC. The combination chemotherapy of oral S‐1 and subcutaneous IFN‐α is a potentially promising treatment strategy for advanced HCC with extrahepatic metastasis. Cancer 2008. ©2008 American Cancer Society.
Role of resection margins in patients treated with breast conservation surgery
Authors: Zavagno Giorgio , Goldin Elena , Mencarelli Roberto , Capitanio Giovanni , Bianco Paola Del , Marconato Renato , Mocellin Simone , Marconato Giorgia , Belardinelli Valentina , Marcon Francesca , Nitti Donato 
Published: March 2008

AbstractBACKGROUNDAfter breast conservation therapy (BCT), margin status is routinely evaluated to select patients who need reexcision. The aim of this study was to investigate how margin status and other clinicopathologic factors correlate with the presence of residual tumor at reexcision.METHODSA series of 431 breast cancer patients who underwent BCT followed by reexcision were considered because they had positive or close (≤3 mm) margins. At univariate and multivariate analysis the frequency of residual tumor in the reexcision specimens was associated with the status and width of resection margins and with a series of other clinicopathologic factors.RESULTSOf the 382 evaluable patients, 253 had positive and 129 close margins. Residual tumor was found at reexcision in 51.8% positive‐margin patients and 34.1% close‐margin patients (P = .001). In the latter group tumor‐margin distance (range, 0.08 to 3 mm) was not associated with the incidence of residual tumor (P = .134). On univariate analysis age ≤45 years (P = .006), intraductal histotype (P = .005), size > 2 cm (P = .010), positive axillary nodes (P = .031), and timing of reexcision (P = .044) were significantly associated with a higher frequency of residual tumor. All these factors, except tumor size, maintained a significant predictive value on multivariate analysis.CONCLUSIONSIn the presence of positive margins, relevant residual disease cannot be ruled out and further surgery is indicated. Close margins do not mandate reexcision because they may indicate either that the tumor has been radically excised or the presence of residual foci of a multifocal tumor, which are usually effectively treated by radiotherapy. Cancer 2008. © 2008 American Cancer Society.
Dietary flavonoid intake and lung cancer—A population‐based case‐control study
Authors: Cui Yan , Morgenstern Hal , Greenland Sander , Tashkin Donald P. , Mao Jenny T. , Cai Lin , Cozen Wendy , Mack Thomas M. , Lu Qing‐Yi , Zhang Zuo‐Feng 
Published: March 2008

AbstractBACKGROUNDLaboratory studies suggest that flavonoids are antimutagenic and anticarcinogenic. To investigate the associations between commonly consumed flavonoid compounds and lung cancer, the authors conducted a population‐based case–control study of 558 lung cancer cases and a group of 837 controls.METHODSDietary intakes of flavonoids were estimated by combining the intake frequency (collected by a food frequency questionnaire), portion size, and food composition data. Unconditional logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence limits (95% CLs) with an adjustment for potential confounders, including age, sex, race‐ethnicity, years of schooling, smoking status, pack‐years of tobacco smoking, and daily energy intake.RESULTSLung cancer was associated inversely with the consumption of epicatechin (in 10 mg per day increment: OR, 0.64; 95% CL, 0.46–0.88), catechin (4 mg per day increment: OR, 0.49; 95% CL, 0.35–0.70), quercetin (9 mg per day increment: OR, 0.65; 95% CL, 0.44–0.95), and kaempferol (2 mg per day increment: OR, 0.68; 95% CL, 0.51–0.90) among tobacco smokers. There was little association between lung cancer and the flavonoid compounds mentioned above among nonsmokers. Regardless of smoking status, there was little association with total flavonoids: thearubigins, hesperetin, naringenin, and myricetin. In addition, consumption of vegetables, tea, and wine, all of which are rich sources of flavonoids, was associated inversely with lung cancer among tobacco smokers.CONCLUSIONSCertain flavonoid compounds, including epicatechin, catechin, quercetin, and kaempferol, were associated inversely with lung cancer among tobacco smokers, but not among nonsmokers. Further studies of these associations may be warranted. Cancer 2008. © 2008 American Cancer Society.
Predicting NMR Relaxation Rates in Anisotropically Tumbling Proteins through Networks of Coupled Rotators
Authors: Nodet Gabrielle , Abergel Daniel , Bodenhausen Geoffrey 
Published: March 2008

AbstractWe show that the prediction of 15N relaxation rates in proteins can be extended to systems with anisotropic global rotational diffusion by using a network of coupled rotators (NCR), starting from a three‐dimensional structure. The relaxation rates predicted by this method are confronted in several examples with experiments performed by other groups. The NCR spectral density functions are compared with the results obtained from reduced spectral density mapping. The consequence of the timescales of internal motions on the predicted relaxation rates and the effects of the predicted local anisotropy—present only in the case of anisotropic overall tumbling—on dynamic parameters, are discussed.
Electron microscopic 3D‐reconstruction of dendritic spines in cultured hippocampal neurons undergoing synaptic plasticity
Authors: Ovtscharoff Wladimir , Segal Menahem , Goldin Miri , Helmeke Carina , Kreher Ute , Greenberger Varda , Herzog Andreas , Michaelis Bernd , Braun Katharina 
Published: March 2008

AbstractDendritic spines are assumed to constitute the locus of neuronal plasticity, and considerable effort has been focused on attempts to demonstrate that new memories are associated with the formation of new spines. However, few studies that have documented the appearance of spines after exposure to plasticity‐producing paradigms could demonstrate that a new spine is touched by a bona fida presynaptic terminal. Thus, the functional significance of plastic dendritic spine changes is not clearly understood. We have used quantitative time lapse confocal imaging of cultured hippocampal neurons before and after their exposure to a conditioning medium which activates synaptic NMDA receptors. Following the experiment the cultures were prepared for 3D electron microscopic reconstruction of visually identified dendritic spines. We found that a majority of new, 1‐ to 2‐h‐old spines was touched by presynaptic terminals. Furthermore, when spines disappeared, the parent dendrites were sometime touched by a presynaptic bouton at the site where the previously identified spine had been located. We conclude that new spines are most likely to be functional and that pruned spines can be transformed into shaft synapses and thus maintain their functionality within the neuronal network. © 2008 Wiley Periodicals, Inc. Develop Neurobiol, 2008.
Semaphorin 3A inhibits ERM protein phosphorylation in growth cone filopodia through inactivation of PI3K
Authors: Gallo Gianluca 
Published: March 2008

AbstractEzrin–radixin–moesin (ERM) proteins are involved in the linkage of membranes to theactin filament (F‐actin) cytoskeleton. Phosphorylation of the C‐terminus activates the F‐actin binding domain of ERM proteins by preventing the action of an autoinhibitory domain. In this study, we investigated whether a growth cone collapsing signal, semaphorin 3A (Sema3A), alters the state of ERM C‐terminus phosphorylation. In the growth cones of dorsal root ganglion axons, phosphorylated ERM proteins localize to filopodia. We report that Sema3A inhibits ERM protein phosphorylation in growth cone filopodia. Significantly, Sema3A decreased ERM phosphorylation prior to the onset of growth cone collapse. Over‐expression of the F‐actin binding fragment of ERM proteins, which competes with endogenous ERM proteins for binding to F‐actin, inhibited filopodial initiation and dynamics. Sema3A has been previously shown to inhibit phosphoinositide 3‐kinase (PI3K) activity. Inhibition of PI3K resulted in the loss of phosphorylated ERM proteins from growth cone filopodia, and treatment with a PI3K activating peptide blocked the effects of Sema3A on ERM phosphorylation. Collectively, these observations demonstrate that inactivation of PI3K in response to Sema3A results in decreased phosphorylation of ERM proteins in filopodia thereby contributing to growth cone collapse. © 2008 Wiley Periodicals, Inc. Develop Neurobiol, 2008.
Generation and characterization of alpha‐chymase‐Cre transgenic mice
Authors: Müsch Werner , Wege Anja K. , Männel Daniela N. , Hehlgans Thomas 
Published: March 2008

AbstractThe Cre‐loxP technology allows the introduction of somatic gene alterations in a tissue and/or cell type specific manner. The development of transgenes that target Cre expression to specific cell types is a critical component in this system. Here, we describe the generation and characterization of transgenic mouse lines expressing Cre recombinase under the control of the baboon α‐chymase promoter, designated Chm:Cre, in order to direct Cre expression specifically to mouse mast cells. Chm:Cre expression was detected in mast cells in lung and colon tissue. Cre‐mediated recombination in these mice identified a population of mature tissue resident mast cells using ROSA26R reporter mice. No Cre‐expression and Cre‐mediated recombination was induced in in vitro generated bone marrow derived mast cells or mast cells isolated from the peritoneal cavity indicating that Cre‐expression under the control of the α‐chymase promoter is solely activated in tissue resident mast cells. These Chm:Cre transgenic mice represent a useful tool to specifically inactivate genes of interest in mast cells of these tissues. genesis 46:163–166, 2008. © 2008 Wiley‐Liss, Inc.
Generation and characterization of Csrp1 enhancer‐driven tissue‐restricted Cre‐recombinase mice
Authors: Snider Paige , Fix Jana L. , Rogers Rhonda , Peabody‐Dowling Goldie , Ingram David , Lilly Brenda , Conway Simon J. 
Published: March 2008

AbstractCell type‐specific genetic modification using the LoxP/Cre system is a powerful tool for genetic analysis of distinct cell lineages. Because of the unique arterial smooth muscle‐restricted expression of a 5.0 kb cysteine‐rich protein (Csrp1) enhancer (Lilly et al.,2001, Dev Biol 240:531–547), we hypothesized that a transgenic Cre line would prove useful for the smooth muscle lineage‐specific genetic manipulation. Here we describe a transgenic mouse line, ECsrp1Cre, where Cre is initially specifically expressed in arterial smooth muscle cells. Use of the ROSA26R reporter allele confirmed that Cre‐mediated recombination in vascular smooth muscle cells began at ∼E10.0 and was highly proficient. Subsequently, Cre is expressed in restricted skeletal and nonvascular smooth muscle lineages. This lineage tracing data is important for future conditional knockout studies to understand where and when Cre‐mediated deletion occurs and where Cre‐expressing daughter cells finally localize. Additionally, we crossed the ECsrp1Cre mice to the ROSA26‐eGFP‐DTA diphtheria toxin A‐expressing mice to genetically ablate ECsrp1Cre expressing cells. This ECsrp1Cre transgenic line should thus prove useful for genetic analysis of diverse aspects of cardiovascular morphogenesis and as a general smooth muscle lineage deletor line. genesis 46:167–176, 2008. © 2008 Wiley‐Liss, Inc.