bluuebunny/crossref_metadata_2025_split huggingface dataset:
The arthritis of sweet's syndrome
Authors: Krauser Ronald E. , Ralph Schumacher H. 
Published: February 2007

AbstractA detailed evaluation of the articular manifestations of Sweet's syndrome is described in a 24‐year‐old man. Fever, mild leukocytosis, tender cutaneous erythematous plaques or nodules with neutrophilic infiltration were accompanied by multiple painful, swollen joints. A knee effusion contained 1,575 leukocytes with many large phagocytic cells. Since it may include significant articular disease, rheumatologists should be aware that this syndrome does exist.
Rheumatoid nodulosis an unusual variant of rheumatoid disease
Authors: Ginsberg Mark H. , Genant Harry K. , Yü T'Sai Fan , Mccarty Daniel J. 
Published: February 2007

AbstractA middle‐aged man developed multiple subcutaneous nodules associated with palindromic rheumatism. There was little evidence of synovitis; however multiple cyst‐like intraosseous radiolucencies were noted. Nodules from two sites were histologically typical rheumatoid nodules. Subjective and objective improvement occurred during penicillamine therapy. This clinical presentation seems sufficiently distinctive to warrant characterization as a variant of rheumatoid disease termed by us: rheumatoid nodulosis..
Treatment of septic arthritis
Authors: Goldenberg Don L. , Brandt Kenneth D. , Cohen Alan S. , Cathcart Edgar S. 
Published: February 2007

AbstractSurgery and needle aspiration have been evaluated as initial modes of drainage in 59 patients with acute septic arthritis. Full recovery was noted in 42% treated surgically at the outset. On the other hand, 67% of those treated by needle aspiration recovered without sequelae, despite the greater prevalence in this group of adverse host factors‐eg, serious underlying illness, concommitant extraarticular infection, prior arthritis in the infected joint, and recent antibiotic or immunosuppressive therapy.
Metastatic adenocarcinoma of synovium presenting as an acute arthritis. diagnosis by closed synovial biopsy
Authors: Goldenberg Don L. , Kelley William , Gibbons Robert B. 
Published: February 2007

AbstractAn acute arthritis may accompany the onset of cancer. A case of metastatic adenocarcinoma of the synovium presenting as an acute arthritis is described. The diagnostic importance of a careful synovial fluid analysis and the use of closed synovial biopsy are emphasized.
Effect of ibuprofen dosage on patient response in rheumatoid arthritis
Authors: Godfrey Robert G. , Cruz Susano De La 
Published: February 2007

AbstractIn a 4‐week double‐blind trial in 41 patients with rheumatoid arthritis, ibuprofen (Motrin®) decreased the swollen joint count significantly at a dosage level of 2400 mg/day, but not at 1200 mg/day. Ibuprofen probably does have antiinflammatory effects in man, but only at higher dosages; antiarthritic activity at lower dosages reflects primarily analgesia and perhaps antipyretic effects. Complaints and clinical laboratory findings did not differ significantly between the dosage groups.
Pathogenic implications of age of onset in juvenile rheumatoid arthritis
Authors: Sullivan Donita B. , Cassidy James T. , Petty Ross E. 
Published: February 2007

AbstractAn analysis of age of onset in juvenile rheumatoid arthritis was performed in the last 300 children seen in our clinic. There was a peak age of onset in girls at 1 to 3 years. Distribution of age of onset in boys was bimodal with the first peak at 2 years of age and the second at 9 years. There was no accentuation of frequency in either sex in the 10‐ to 14‐year age group. The distribution of age of onset was bimodal in both monarticular and polyarticular onset of disease, but no particular modal age of onset was seen with systemic onset of disease. It is possible that these data reflect that JRA is not a homogeneous disease, or that there are age‐sex related differences in host susceptibility or pathogenoc agents.
Selective suppression of autoantibody responses in NZB/NZW MICE treated with long‐term cyclophosphamide
Authors: Walker Sara Ellen , Bole Giles G. 
Published: February 2007

AbstractAutoimmune responses were assayed in 80 cyclophosphamide‐treated and control NZB/NZW mice over a period of 1 year. Fluctuation between positive and negative immunofluorescent heterogeneous ANA tests and daily alterations of ANA titers were detected in young mice of both sexes. Although highdose cyclophosphamide therapy (8 mg/kg/day) failed to prevent the spontaneous appearance of ANA, titered ANA values were partially suppressed in highdose treated mice. This study permitted sequential comparisons between ANA titers and anti‐DNA as useful indices of cyclophosphamide‐induced suppression of autoimmune disease. ANA titers were relalively resistant to cyclophosphamide therapy. Antibodies directed specifically against DNA were suppressed in mice receiving high‐dose cyclophosphamide. In treated animals, decreased anti‐DNA levels were associated with protection from severe glomerulonephritis and renal vasculitis. Treatment with lowdose cyclophosphamide (1 mg/kg/day) appeared paradoxically to stimulate autoantibody production and renal disease/vasculitis.
Septic arthritis in sickle‐cell thalassemia
Authors: Palmer Donald W. 
Published: February 2007

AbstractThe knee of a boy with sickle‐cell thalassemia became infected with Salmonella enteritidis, sensitive to ampicillin. Doses of ampicillin that achieved antibacterial titers of 32 in synovial fluid failed to eradicate the organism. The synovial fluid exhibited severe hypoxia, hypercapnia, and lactic acidosis. Methods were developed to estimate the oxygen saturation of blood in regional venous capillaries, the degree of periarticular sickling, changes in the viscosity of local blood, and the articular ratio of blood flow to oxygen utilization. The results suggest that local vascular insufficiency associated with sickling may affect host response to infection and efficacy of antibiotics. The Salmonella C1 readily transformed to an L form on hypertonic medium, thus acquiring resistance to ampicillin and other cell‐wall inhibitors.
Thiemann' disease a brief reminder
Authors: Rubinstein Herbert M. 
Published: February 2007

AbstractTwo brothers with Thiemann' disease are described and the accumulated world literature is briefly reviewed. Thiemann' disease is considered to be a form of idiopathic avascular necrosis of the PIP joints of the hands, with occasional involvement of other joints. The characteristic deformity and x‐ray findings are reviewed. Thiemann' disease is a genetic disorder and, in families in which detail is available, is inherited as an autosomal dominant with virtual complete penetrance.
Wrist arthropathy in calcium pyrophosphate dihydrate deposition disease
Authors: Utsinger Peter D. , Resnick Donald , Zvaifler Nathan J. 
Published: February 2007

AbstractCalcium pyrophosphate dihydrate deposition disease is associated with chondrocalcinosis and a characteristic radiographic abnormality. In the wrist this abnormality consists of radiocarpal joint narrowing, sclerosis, and subchondral cystic degeneration of the carpal bones. These changes sometimes occur in the absence of chondrocalcinosis. To investigate the significance of this occurrence, 18 patients with the radiographic abnormality of radiocarpal joint narrowing, sclerosis, and subchondral cystic degeneration were examined. Six had neither local wrist nor distant chondrocalcinosis. Five of the latter had wrist arthrocentesis and 4 had calcium pyrophosphate dihydrate crystals. Calcium pyrophosphate dihydrate deposition disease can occur in the absence of chondrocalcinosis and the diagnosis is strongly suggested by a characteristic radiographic picture.
Development of antibodies to ribonucleoprotein following short‐term therapy with procainamide
Authors: Winfield John B. , Koffler David , Kunkel Henry G. 
Published: February 2007

AbstractAn autoimmune response to certain nuclear antigens frequently develops in patients receiving prolonged therapy with procainamide. In order to define events involved in the initiation of this immune response, patients with myocardial infarction were studied early after starting procainamide and at later times. Polynucleotide antibodies and circulating polynucleotide antigens were sought by sensitive assay techniques in the sera of these patients. Very high titers of antiribonucleoprotein developed selectively in the majority of these patients after short‐term therapy with procainamide. Such antibodies were infrequent in the long‐term therapy group, most of whose members exhibited anti‐single‐strand DNA and were symptomatic with overt procainamide‐induced lupus. Patients with acute myocardial infarction who did not receive procainamide did not develop anti‐polynucleotide antibodies, but rather had high levels of free ribonucleoprotein antigen in their serum. Various interpretations of these data are discussed.
Association of cold‐reactive antilymphocyte antibodies with lymphopenia in systemic lupus erythematosus
Authors: Winfield John B. , Winchester Robert J. , Kunkel Henry G. 
Published: February 2007

AbstractIn a prospective study 26 of 29 patients with systemic lupus erythematosus had cold‐reactive antilymphocyte antibodies cytotoxic for autologous lymphocytes and lymphocytes from normal subjects. The level of antilymphocyte antibodies was highly correlated, by linear regression analysis, with lymphopenia in these patients. The data suggested that both the avidity and the concentration of these antibodies were important determinants in this relationship. A clear association between increased antilymphocyte antibody activity and exacerbation of SLE was demonstrated. Apart from lymphopenia, however, neither type of clinical manifestation nor any particular serologic abnormality appeared to be related to the presence of antilymphocyte antibodies.
Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure
Authors: Bennett Robert M. , Lehr James R. , McCarty Daniel J. 
Published: February 2007

AbstractFour patients with chondrocalcinosis of the knees volunteered for joint lavage. Preliminary experiments indicated that disodium EDTA and magnesium ions were potent solubilizers of CPPD crystals. The procedure was a therapeutic failure in that insignificant amounts of CPPD were removed and all 4 subjects developed postlavage attacks of pseudogout. It is hypothesized that the acute attack of pseudogout is a result of crystal shedding and may be triggered by any factor that enhances CPPD solubility.
Coexistence of ankylosing spondylitis and rheumatoid arthritis
Authors: Luthra Harvinder S. , Ferguson Richard H. , Conn Doyt L. 
Published: February 2007

AbstractAnkylosing spondylitis and rheumatoid arthritis share many common features. However the presence of rheumatoid factor, histologically classic rheumatoid nodules, and the histocompatibility cell wall antigen (HLA‐B27) helps distinguish one from the other. Two cases are reported in which these features established the coexisting diagnoses of ankylosing spondylitis and rheumatoid arthritis.
Histocompatibility antigens in systemic lupus erythematosus
Authors: Goldberg Marc A. , Arnett Frank C. , Bias Wilma B. , Shulman Lawrence E. 
Published: February 2007

AbstractHistocompatibility (HL‐A) antigens were determined in 120 patients with systemic lupus erythematosus (SLE) and 120 matched controls. Increased frequencies of HL‐A1 and HL‐A8 were found. HL‐A1 was more strongly associated with SLE in black patients (71 patients), whereas HL‐A8 was more impressively associated with SLE in white patients (49 patients). In addition HL‐A1 appeared more frequently in those with early onset of disease in both races; and HL‐A1, HL‐A8, and the HL‐A1,8 phenotype seemed to be associated with severe SLE (renal and central nervous system involvement) in white patients. These data support the proposal that there are genetic influences in the pathogenesis and expression of SLE.
Lupus erythematosus in a patient with amyloidosis, adrenal insufficiency, and subsequent immunoblastic sarcoma. Demonstration of the le phenomenon in the lung
Authors: Schleissner L. A. , Sheehan William W. , Orselli Richard C. 
Published: February 2007

AbstractA patient with systemic lupus erythematosus of long duration developed secondary amyloidosis and finally died after the additional complication of malignant lymphoproliferative disease. Multiple system involvement, typical serologic findings, and postmortem evidence substantiated the diagnosis of lupus erythematosus. Amyloid deposition was found in several organs, but was notably extensive in the adrenal cortex. This extensive deposition resulted in adrenal insufficiency, which was diagnosed clinically and treated until the patient's death from lymphoma. The particular nature of the malignant lymphoma is emphasized; a distinctive feature was the disappearance of positive lupus erythematosus cells from the buffy coat and the reduction in titers of relevant serologic tests toward the end of the illness. In spite of this reduction, many hematoxylin bodies and abundant complete lupus erythematosus cells were found in the lungs on postmortem examination.
Effect of prophylactic colchicine therapy on leukocyte function in patients with familial mediterranean fever
Authors: Dinarello Charles A. , Chusid Michael J. , Fauci Anthony S. , Gallin John I. , Dale David C. , Wolff Sheldon M. 
Published: February 2007

AbstractPatients with familial Mediterranean fever (FMF) who were part of a double‐blind trial of daily colchicine as prophylaxis for their disease had leukocyte functions studied while receiving colchicine or placebo. Leukocytes taken from these patients while on prophylactic doses of colchicine produced normal quantities of leukocytic pyrogen, ingested bacteria normally, and migrated normally in chemotactic chambers. In addition these patients had normal numbers of circulating T and B lymphocytes as well as normal blastogenic responses of their peripheral lymphocytes to mitogenic stimuli. The patients on colchicine, however, had significantly fewer neutrophils and monocytes accumulating at skin‐window sites 24 hours after the initial abrasion. Because the early phase of the skin‐window response was normal in these patients, the decreased late response may be related to a failure to amplify the initial inflammatory reaction. The reduced capacity to generate a normal inflammatory response may account for the failure of these patients to develop full attacks while taking colchicine.
Comparison of the complement‐fixing activity of antinuclear antibodies in lupus nephritis, mixed connective tissue disease, and scleroderma
Authors: Parker Michael Dean , Turner Robert A. 
Published: February 2007

AbstractComplement‐fixing antinuclear antibody (CFANA) titers were measured in 18 patients with lupus nephritis and were compared to titers in 22 patients with scleroderma and mixed connective tissue disease (MCTD) who had comparable ANA titers but lacked nephritis. CFANA titers were higher in SLE patients with nephritis than in a control group of SLE patients without nephritis but were no higher than in scleroderma or MCTD. Thus the striking differences in the prevalence of nephritis among these patients with high titer ANA cannot be explained by differences in complement fixation by these antibodies.
Carcinomatous polyarthritis. The presenting symptom of an ovarian tumor and association with a platelet activating factor
Authors: Bennett Robert M. , Ginsberg Mark H. , Thomsen Sharon 
Published: February 2007

AbstractA 59‐year‐old white female presented with an acute polyarthritis, fever, and mental confusion. Accompanying blood changes included positive tests for rheumatoid factor and antinuclear factor, anemia, leukocytosis, thrombocytosis, and a circulating factor that stimulated serotonin release from normal platelets. Exploratory laporatomy for a mobile pelvic mass revealed an adenocarcinoma of the left ovary which was completely resected. Shortly thereafter the patient's acute symptoms subsided. After 2 years of follow‐up the patient has remained free of symptoms and the serologic changes have reverted to normal.
An epidemic of oligoarticular arthritis in children and adults in three connecticut communities
Authors: Steere Allen C. , Malawista Stephen E. , Snydman David R. , Shope Robert E. , Andiman Warren A. , Ross Martin R. , Steele Francis M. 
Published: February 2007

AbstractAn epidemic form of arthritis has been occurring in eastern Connecticut at least since 1972, with the peak incidence of new cases in the summer and early fall. Its identification has been possible because of tight geographic clustering in some areas, and because of a characteristic preceding skin lesion in some patients. The authors studied 51 residents of three contiguous Connecticut communities—39 children and 12 adults—who developed an illness characterized by recurrent attacks of asymmetric swelling and pain in a few large joints, especially the knee. Attacks were usually short (median: 1 week) with much longer intervening periods of complete remission (median: 2.5 months), but some attacks lasted for months. To date the typical patient has had three recurrences, but 16 patients have had none. A median of 4 weeks (range: 1–24) before the onset of arthritis, 13 patients (25%) noted an erythematous papule that developed into an expanding, red, annular lesion, as much as 50 cm in diameter. Only 2 of 159 family members of patients had such a lesion and did not develop arthritis (P < 0.000001). The overall prevalence of the arthritis was 4.3 cases per 1,000 residents, but the prevalence among children living on four roads was 1 in 10. Six families had more than 1 affected member. Nine of 20 symptomatic patients had low serum C3 levels, compared to none of 31 asymptomatic patients (P < 0.005); no patient had iridocyclitis or a positive test for antinuclear antibodies. Neither cultures of synovium and synovial fluid nor serologic tests were positive for agents known to cause arthritis. “Lyme arthritis” is thought to be a previously unrecognized clinical entity, the epidemiology of which suggests transmission by an arthropod vector.
Stimulatory effect of metoclopramide on the esophagus and lower esophageal sphincter of patients with pss
Authors: Ramirez‐Mata Manuel , Ibanez Graciela , Alarcon‐Segovia Donato 
Published: February 2007

AbstractMetoclopramide has been shown to stimulate motility of the gastrointestinal tract, including the esophagus. The authors therefore tested the effect of intravenous injections of metoclopramide on the sphincteric pressure and esophageal motility in 14 patients with esophageal dysfunction due to progressive systemic sclerosis (PSS). Isotonic saline similarly injected in a control period in 7 of the patients showed no effect. None of the 14 patients had a detectable pressure zone at the sphincteric area in basal conditions, but following the injection of metoclopramide, one appeared in 7 patients. Metoclopramide also caused the appearance of pressure waves in 5 of 11 patients who had aperistalsis, and caused up to a threefold increase in the amplitude of the pressure waves in the 3 patients who had hypomotility of the esophagus.
Lactoferrin and lysozyme levels in synovial fluid
Authors: Bennett Robert M. , Skosey John L. 
Published: February 2007

AbstractLysozyme and lactoferrin levels were measured in 71 synovial fluids (SF) of patients with traumatic effusions, osteoarthritis, rheumatoid arthritis, pseudogout, septic arthritis, and gout, as well as in 91 synovial fluids graded according to their neutrophil count. Elevated lysozyme levels were found in all the inflammatory arthritides and also in osteoarthritis. Lactoferrin levels were not increased in osteoarthritis but displayed a close correlation to the extent of the inflammatory response as judged by SF neutrophilia. The ratio of lysozyme to lactoferrin decreased progressively with increasing SF neutrophilia. In vitro experiments showed that lactoferrin is released from neutrophils isochronously with lysozyme and β‐glucuronidase. Lactoferrin was not found in hyaline cartilage, a tissue known to contain lysozyme. These results are consistent with the belief that SF lysozyme has a major derivation from both cartilage and neutrophils, and that lactoferrin arises only from neutrophils. These findings indicate that the simultaneous measurement of lysozyme and lactoferrin provides a potentially useful index of both joint inflammation and cartilage degradation.
Chronic arthropathy associated with rubella vaccination
Authors: Spruance Spotswood L. , Metcalf Robert , Smith Charles B. , Griffiths Marie M. , Ward John R. 
Published: February 2007

AbstractEleven children suffered recurrent episodes of knee stiffness (“catcher's crouch syndrome”) after receiving HPV‐77DK12 rubella vaccine. One was evaluated by arthroscopy and the synovium was found to be hypertrophied posteriorly and to protrude in folds into the intercondylar notch and lateral joint space. Culture for rubella virus was unsuccessful. The authors' observations provide evidence that “catcher's crouch syndrome” is a synovial disease and that chronic joint disease can be a sequela of rubella immunization.
Spontaneous rupture of the liver
Authors: Levitin Peter M. , Sweet Donald , Brunner Carolyn M. , Katholi Richard E. , Bolton W. Kline 
Published: February 2007

AbstractA patient with systemic lupus erythematosus developed an acute surgical abdomen secondary to spontaneous rupture of the liver and died. Postmortem examination revealed an arteritis of the liver, pancreas, adrenal gland, skeletal muscle, and spleen. It appeared that an arteritis of the liver produced areas of infarction that ruptured and caused the clinical findings.
Homozygosity For HLA‐B27
Authors: Arnett Frank C. , Schacter Bernice Z. , Hochberg Marc C. , Hsu Susan H. , Bias Wilma B. 
Published: February 2007

AbstractThe effect of homozygosity for HLA‐B27 on the clinical expression of rheumatic disease was studied in two families. The 1 homozygous patient in each of two families demonstrated extraordinarily severe peripheral and axial arthritis compared to other affected heterozygous relatives. In addition, predominant peripheral or axial disease appeared to segregate with different B27 haplotypes. The 2 homozygous patients were not homozygous at the HLA‐A, C, or D loci.
Central nervous system involvement in sle
Authors: Small Peter , Mass M. F. , Kohler Peter F. , Harbeck Ronald J. 
Published: February 2007

AbstractThe clinical course and diagnostic profile of 13 patients with central nervous system involvement and systemic lupus erythematosus (CNS‐SLE) are presented. The diagnostic yield for each procedure was measured as the percent abnormal: CSF total protein was 38%; increased CSF IgG 69%; decreased CSF hemolytic C4 10%; increased CSF anti‐DNA 64%; electroencephalogram 80%; flow brain scan 50%; and static brain scan 0%. No single procedure was consistently abnormal, but the battery of tests provided a useful and specific CNS‐SLE diagnostic profile.
Preliminary criteria for the classification of the acute arthritis of primary gout
Authors: Wallace Stanley L. , Robinson Harry , Masi Alfonse T. , Decker John L. , Mccarty Daniel J. , Yü T'sai‐fan 
Published: February 2007

AbstractThe American Rheumatism Association subcommittee on classification criteria for gout analyzed data from more than 700 patients with gout, pseudogout, rheumatoid arthritis, or septic arthritis. Criteria for classifying a patient as having gout were a) the presence of characteristic urate crystals in the joint fluid, and/or b) a tophus proved to contain urate crystals by chemical or polarized light microscopic means, and/or c) the presence of six of the twelve clinical, laboratory, and X‐ray phenomena listed in Table 5.