bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addressing the gap in information security: an HR-centric and AI-driven framework for mitigating insider threats
Authors: Thite Mohan , Iyer Ramanathan 
Published: February 2024

PurposeDespite ongoing reports of insider-driven leakage of confidential data, both academic scholars and practitioners tend to focus on external threats and favour information technology (IT)-centric solutions to secure and strengthen their information security ecosystem. Unfortunately, they pay little attention to human resource management (HRM) solutions. This paper aims to address this gap and proposes an actionable human resource (HR)-centric and artificial intelligence (AI)-driven framework.Design/methodology/approachThe paper highlights the dangers posed by insider threats and presents key findings from a Leximancer-based analysis of a rapid literature review on the role, nature and contribution of HRM for information security, especially in addressing insider threats. The study also discusses the limitations of these solutions and proposes an HR-in-the-loop model, driven by AI and machine learning to mitigate these limitations.FindingsThe paper argues that AI promises to offer many HRM-centric opportunities to fortify the information security architecture if used strategically and intelligently. The HR-in-the-loop model can ensure that the human factors are considered when designing information security solutions. By combining AI and machine learning with human expertise, this model can provide an effective and comprehensive approach to addressing insider threats.Originality/valueThe paper fills the research gap on the critical role of HR in securing and strengthening information security. It makes further contribution in identifying the limitations of HRM solutions in info security and how AI and machine learning can be leveraged to address these limitations to some extent.
Developing a clamshell thoracotomy training model to support hybrid teaching in simulation‐based education
Authors: Roche Adam F , Voborsky Miroslav , Meighan Victoria , O'Connor Gerard , Eppich Walter J , Condron Claire M 
Published: February 2024

AbstractObjectiveThoracotomy is an acute, time‐sensitive procedure. Simulation‐based education provides a safe‐learning platform to learn these techniques under close supervision.MethodsWe used the spiral model and concepts of functional fidelity to guide the evolutionary design and fabrication of a hybrid thoracotomy simulator.ResultsThis model simulates a clamshell thoracotomy that physically integrates with bespoke manikins and adds a high‐fidelity technical skills element to immersive team‐based simulation training.ConclusionsWe describe the creation of a thoracotomy simulation model that allows trainees to practice these techniques in a safe‐learning environment.
Red pandas with different diets and environments exhibit different gut microbial functional composition and capacity
Authors: LU Yunwei , ZHANG Liang , LIU Xu , LAN Yue , WU Lixia , WANG Jiao , WU Kongju , YANG Chaojie , LV Ruiqing , YI Dejiao , ZHUO Guifu , LI Yan , SHEN Fujun , HOU Rong , YUE Bisong , FAN Zhenxin 
Published: February 2024

AbstractThe red panda (Ailurus fulgens) is a distinctive mammal known for its reliance on a diet primarily consisting of bamboo. The gut microbiota and overall health of animals are strongly influenced by diets and environments. Therefore, conducting research to explore the taxonomical and functional variances within the gut microbiota of red pandas exposed to various dietary and environmental conditions could shed light on the dynamic complexities of their microbial communities. In this study, normal fecal samples were obtained from red pandas residing in captive and semi‐free environments under different dietary regimes and used for metabolomic, 16S rRNA, and metagenomic sequencing analysis, with the pandas classified into four distinct cohorts according to diet and environment. In addition, metagenomic sequencing was conducted on mucus fecal samples to elucidate potential etiological agents of disease. Results revealed an increased risk of gastrointestinal diseases in red pandas consuming bamboo shoots due to the heightened presence of pathogenic bacteria, although an increased presence of microbiota‐derived tryptophan metabolites appeared to facilitate intestinal balance. The red pandas fed bamboo leaves also exhibited a decrease in gut microbial diversity, which may be attributed to the antibacterial flavonoids and lower protein levels in leaves. Notably, red pandas residing in semi‐free environments demonstrated an enriched gut microbial diversity. Moreover, the occurrence of mucus secretion may be due to an increased presence of species associated with diarrhea and a reduced level of microbiota‐derived tryptophan metabolites. In summary, our findings substantiate the influential role of diet and environment in modulating the gut microbiota of red pandas, offering potential implications for improved captive breeding practices.
Environmental DNA metabarcoding of freshwater fish in Malaysian tropical rivers using short‐read nanopore sequencing as a potential biomonitoring tool
Authors: Munian Kaviarasu , Ramli Farah Farhana , Othman Nursyuhada , Mahyudin Nur Aina Amira , Sariyati Nur Hartini , Abdullah‐Fauzi Nurfatiha Akmal Fawwazah , Haris Hidayah , Ilham‐Norhakim Mohd Lokman , Abdul‐Latiff Muhammad Abu Bakar 
Published: February 2024

AbstractThe approach of combining cost‐effective nanopore sequencing and emerging environmental DNA (eDNA) metabarcoding could prove to be a promising tool for biodiversity documentation, especially in Malaysia. Given the substantial funding constraints in recent years, especially in relation to the country's biodiversity, many researchers have been limited to conduct restricted research without extended monitoring periods, potentially hindering comprehensive surveys and could compromise the conservation efforts. Therefore, the present study aimed to evaluate the application of eDNA metabarcoding on freshwater fish using short reads generated through nanopore sequencing. This assessment focused on species detection in three selected rivers within the Endau Rompin Landscape in Malaysia. Additionally, the study compared levels of species detection between eDNA metabarcoding and conventional sampling methods, examined the effectiveness of primer choice, and applied both metabarcoding and shotgun sequencing to the eDNA approach. We successfully identified a total of 22 and 71 species with an identification threshold of >97% and >90%, respectively, through the MinION platform. The eDNA metabarcoding approach detected over 13% more freshwater fish species than when the conventional method was used. Notably, the distinction in freshwater fish detection between eDNA primers for 12S rRNA and cytochrome oxidase I was insignificant. The cost for eDNA metabarcoding proved to be more effective compared to conventional sampling with cost reduction at 33.4%. With favourable cost‐effectiveness and increased species detection, eDNA metabarcoding could complement existing methods, enhance holistic diversity documentation for targeted habitats and facilitate effective conservation planning.
Alterations in epidermal stem cells within the pilosebaceous unit in atrophic acne scars
Authors: Kim Dong Hyo , Yoon Ji Young , Lee Jun Hyo , Suh Dae Hun 
Published: February 2024

AbstractBackgroundAtrophic acne scarring is a common sequela of inflammatory acne, causing significant problems for affected patients. Although prolonged inflammation and subsequent aberrant tissue regeneration are considered the underlying pathogenesis, the role of epidermal stem cells, which are crucial to the regeneration of pilosebaceous units, remains unknown.ObjectivesTo examine the changes occurring in epidermal stem cells in atrophic acne scars.MethodsChanges in collagen, elastic fibre and human leukocyte antigen (HLA)‐DR expression were analysed in normal skin and inflammatory acne lesions at days 1, 3 and 7 after development. The expression of epidermal stem cell markers and proliferation markers was compared between normal skin and mature atrophic acne scar tissue.ResultsIn acne lesions, inflammation had invaded into pilosebaceous units over time. Their normal structure had been destructed and replaced with a reduced amount of collagen and elastic fibre. Expression of stem cell markers including CD34, p63, leucine‐rich repeat‐containing G protein‐coupled receptor (LGR)6 and LGR5, which are expressed in the interfollicular epidermis, isthmus and bulge of hair follicles, significantly decreased in atrophic acne scar tissue compared to normal skin. Epidermal proliferation was significantly reduced in scar tissue.ConclusionsThese findings suggest that as inflammatory acne lesions progress, inflammation gradually infiltrates the pilosebaceous unit and affects the resident stem cells. This disruption impedes the normal regeneration of the interfollicular epidermis and adnexal structures, resulting in atrophic acne scars.
Tempering senses of superiority: The virtue of magnanimity in democracies
Authors: Kim Juman 
Published: February 2024

AbstractRecent years have witnessed growing concerns about mutual disrespect and civic enmity among democratic citizens. Ordinary people often find themselves in a particularly adversarial condition in which they shamelessly disregard their opponents and hold them in contempt, and vice versa. Each tends to assert their superiority while appearing to be impudent to one another. Instead of simply calling for mutual respect—deliberative or agonistic—this article aims to understand why people are prone to treating their opponents with disrespect in such an impassioned situation and how to temper the pleasing sense of superiority while redirecting its very motivational power toward better ends. Drawing primarily from Aristotle's Rhetoric, my account of magnanimity shows that the magnanimous can better manage to interact with their opponents, retaining their sense of superiority necessary for active political participation while at once preventing themselves from the downward spiral of the politics of impudence.
Comparative study of socially responsible consumption measurement in three Latin American countries
Authors: Villa‐Castaño Lida Esperanza , Perdomo‐Ortiz Jesús , Dueñas‐Ocampo Sebastián , Durán León William Fernando 
Published: February 2024

AbstractSocially responsible consumption reflects a consumer's political and ethical act. Its measurement is dependent on the socio‐economic and cultural context. Consequently, measurement instruments reflecting various behaviour profiles of global consumers have been developed. This study employs a Latin‐American‐specific measurement instrument to compare socially responsible consumption behaviours in Colombia, Mexico and Peru, countries with the same cultural cluster, that is they reflect a set of values shaped by religion, family, a sense of authority and a nationalist bias in their cultural pattern. The empirical test included confirmatory factorial analysis exercise, factorial invariance analysis and a contrast analysis of variance. The results for the three Latin American countries show the following. (i) The Mexican consumer, compared to the Peruvian and Colombian one, exhibits a stronger tendency to evaluate external practices of corporate social responsibility as a criterion of consumption. (ii) The rationality of the Mexican consumer is better in terms of consumption volume of products, resources and services. Finally, (iii) Peruvian and Mexican consumers (vs. Colombian consumers) exhibit a tendency to assess the responsible practices of companies in labour matters more as a consumption criterion. This study provides empirical evidence of the context‐dependent nature of measuring socially responsible consumption. For practitioners, identifying consumer profiles based on the market context enables them to customise goods and services. Moreover, policymakers should implement a sustainable consumption agenda with public policy guidelines tailored to the specific context.
Impact of elranatamab on quality of life: Patient‐reported outcomes from MagnetisMM‐3
Authors: Mohty Mohamad , Bahlis Nizar J. , Nooka Ajay K. , DiBonaventura Marco , Ren Jinma , Conte Umberto 
Published: February 2024

SummaryThe physical and emotional burden of relapsed or refractory multiple myeloma (RRMM) has been strongly correlated with declining health‐related quality of life (QOL) in the patients it affects. This analysis evaluated patient‐reported outcomes (PROs) from B‐cell maturation antigen (BCMA)‐naive (n = 123) and ‐exposed (n = 64) patients with RRMM enrolled in the MagnetisMM‐3 study (NCT04649359) and treated with the humanized, bispecific BCMA‐CD3 antibody elranatamab. Patients received two step‐up doses of elranatamab (12 mg on day 1, 32 mg on day 4) before starting the full dose of 76 mg on day 8 (each cycle = 28 days). Global health status, functioning and symptom data were collected electronically using validated and myeloma‐specific questionnaires. Improvements in PROs occurred early, with marked reductions in pain and disease symptoms and notable improvements in patients’ outlook for their future health. Additionally, 40.2% of BCMA‐naive and 52.6% of BCMA‐exposed patients perceived their disease as ‘a little better’ or ‘much better’ by Cycle 1, Day 15. The results from this analysis demonstrated that elranatamab maintained or improved symptomology and general health status, regardless of prior BCMA‐directed therapy. Thus, in addition to its clinical benefits, elranatamab therapy may sustain or improve QOL in heavily pretreated patients with RRMM.
Functional analysis and transcriptome profile of meninges and skin fibroblasts from human‐aged donors
Authors: Fantini Valentina , Ferrari Riccardo Rocco , Bordoni Matteo , Spampinato Eleonora , Pandini Cecilia , Davin Annalisa , Medici Valentina , Gagliardi Stella , Guaita Antonio , Pansarasa Orietta , Cereda Cristina , Poloni Tino Emanuele 
Published: February 2024

AbstractThe central nervous system (CNS) is surrounded by three membranes called meninges. Specialised fibroblasts, originating from the mesoderm and neural crest, primarily populate the meninges and serve as a binding agent. Our goal was to compare fibroblasts from meninges and skin obtained from the same human‐aged donors, exploring their molecular and cellular characteristics related to CNS functions. We isolated meningeal fibroblasts (MFs) from brain donors and skin fibroblasts (SFs) from the same subjects. A functional analysis was performed measuring cell appearance, metabolic activity, and cellular orientation. We examined fibronectin, serpin H1, β‐III‐tubulin, and nestin through qPCR and immunofluorescence. A whole transcriptome analysis was also performed to characterise the gene expression of MFs and SFs. MFs appeared more rapidly in the post‐tissue processing, while SFs showed an elevated cellular metabolism and a well‐defined cellular orientation. The four markers were mostly similar between the MFs and SFs, except for nestin, more expressed in MFs. Transcriptome analysis reveals significant differences, particularly in cyclic adenosine monophosphate (cAMP) metabolism and response to forskolin, both of which are upregulated in MFs. This study highlights MFs' unique characteristics, including the timing of appearance, metabolic activity, and gene expression patterns, particularly in cAMP metabolism and response to forskolin. These findings contribute to a deeper understanding of non‐neuronal cells' involvement in CNS activities and potentially open avenues for therapeutic exploration.
Stenotrophomonas maltophilia skin infection in an immunocompetent patient: Primary cutaneous CD30+ T‐cell lymphoproliferative disorder or pseudolymphoma?
Authors: Prete Monia Di , Scarabello Alessandra , Lora Viviana , Cota Carlo 
Published: February 2024

AbstractCutaneous pseudolymphomas are a wide group of diseases mimicking cutaneous lymphoma. They comprise several skin conditions with different etiopathogenesis, clinical–pathological features, and prognosis, which may occur in the absence of an identifiable trigger factor or after administration of medications or vaccinations, tattoos, infections, or arthropod bites. They present with different manifestations: from solitary to regionally clustered lesions, up to generalized distribution and, in rare cases, erythroderma. They persist variably, from weeks to years, and resolve spontaneously or after antibiotics, but may recur in some cases. CD30+ T‐cell pseudolymphomas are characterized by the presence of large, activated lymphoid cells, generally in response to viral infections, arthropod assault reactions, and drug eruptions. Stenotrophomonas maltophilia is a ubiquitous Gram‐negative bacillus responsible for opportunistic infections in immunocompromised patients. Infection of intact skin in immunocompetent patients is particularly rare. Here, we report a case of a man presenting an isolated nodule histopathologically mimicking a primary cutaneous CD30+ T‐cell lymphoproliferative disorder.
Do wages underestimate the inequality in workers' rewards? The joint distribution of job quality and wages across occupations
Authors: Clark Andrew E. , Cotofan Maria , Layard Richard 
Published: February 2024

AbstractInformation on both wages and job quality is needed in order to understand the occupational dispersion of wellbeing. We analyse subjective wellbeing in a large UK sample to construct a measure of ‘overall reward’, the sum of wages and the value of job quality, in 90 different occupations. If only wages are included, then labour market inequality is underestimated: the dispersion of overall rewards is one‐third larger than the dispersion of wages. Our findings are similar, and stronger, in data on US workers. We find a positive correlation between job quality and wages in all specifications, both between individuals in the cross‐section and within individuals in panel data. The gender and ethnic gaps in the labour market are larger than those in wages alone, and the overall rewards to education on the labour market are underestimated by earnings differentials alone.
Creation and evaluation of an educational escape room for preclinical training on 3D printing in dentistry
Authors: Caussin Élisa , Qatramiz Ahmad , Guillemot Caroline , Brukarz Yohann , Loré Vinciane , Jungo Sébastien , Gouze Hélène , Le‐goff Stéphane , Dursun Elisabeth , Attal Jean‐Pierre , François Philippe 
Published: February 2024

AbstractIntroductionThe benefit of pedagogical escape rooms for dental students' stimulation, interest and knowledge strengthening has been suggested by several studies. However, in previous studies, only a few students were evaluated. This study aims to confirm the purpose of this innovative pedagogical tool in terms of learning consolidation and team building from students' perceptions. We directly incorporated an educational escape game into the fundamental academic formation as a practical‐work course for fifth‐year dental students.Materials and MethodsThe present escape game focused on 3D printing, whose implementation fit the different steps of an escape game well. This study was conducted in March 2022. All fifth‐year dental students (n = 212) were divided into 5–6 student groups to match the conditions of an escape game. Before entering the room, each student had to complete a cross‐sectional knowledge true/false test of 8 questions to assess their general level. Additionally, an 18‐question appreciation survey was completed when leaving the room.ResultsThe students perceived the 3D‐printing escape game to be relevant and especially expressed the benefit of being part of a team to exchange and build knowledge. These results suggest knowledge strengthening. The instructional benefit of this process seemed to exceed its mere fun and appealing aspect.ConclusionOur results with a large number of students showed that, from the students' perception, the educational escape game significantly improved knowledge and team‐building. It created a supportive learning environment and increased students' motivation. It can provide a fun and effective way to diversify instruction.
Geographical and cognitive proximity effects on innovation performance: Which types of proximity for which types of innovation?
Authors: Garcia Martinez Marian , Zouaghi Ferdaous , Sánchez García Mercedes 
Published: February 2024

AbstractThe purpose of the paper is to explore the multi‐dimensional and intersecting nature of proximity to drive innovation performance. Applying a multi‐dimensional proximity framework, the study provides a deeper understanding of the importance of substitution and overlap mechanisms in the relation between geographical and cognitive proximity dimensions in innovation performance. The paper further analyses the moderation effect of organisational innovation in this relationship. Multivariate analysis proves the interaction effects between geographical and cognitive proximity, where cognitive proximity both substitutes and complements geographical proximity. However, external knowledge search for innovation along proximity dimensions differs depending on the type of innovation. Our findings corroborate the proximity paradox caused by lock‐in effects with the optimal level of proximity influenced by the interdependencies between proximity dimensions. This inverse U‐shaped relationship is flatter for firms that have adopted organisational innovation. External knowledge linkages should be tailored to the favourable characteristic of proximity to enhance firm innovation performance.
Testing models of increasing complexity to develop ecosystem‐informed fisheries advice
Authors: Robertson Matthew D. , Cadigan Noel G. , Regular Paul M. , Koen‐Alonso Mariano , Cyr Frédéric , Zhang Fan , Eddy Tyler D. 
Published: February 2024

AbstractDespite continued calls for the application of ecosystem‐based fisheries management, tactical fisheries management continues to be heavily reliant on single‐species stock assessments. These stock assessments rarely quantitatively integrate the effects of ecosystem processes on fish stock productivity. This lack of integration is ultimately driven by the complexity of interactions between populations, ecosystems and fisheries, which produces uncertainty when defining which processes to include and how to include them. Models developed using a structured hypothesis testing framework would allow formalizing uncertainties while underscoring the importance of incorporating different population and ecosystem processes to explain non‐stationary stock productivity. Here, we develop a conceptual framework for extending and comparing population dynamics models of increasing complexity. We illustrate the utility of the framework by investigating the population and ecosystem processes that most likely affected the differential recovery of two flatfish populations (American plaice and yellowtail flounder) on the Newfoundland Grand Banks over the past three decades. We found that yellowtail flounder population dynamics were primarily driven by recruitment variability, which was negatively affected by warmer climatological conditions, as indicated by an integrated regional climate index. Meanwhile, American plaice population dynamics were affected by a combination of temporal variability in recruitment and natural mortality, where natural mortality increased during colder than average conditions. By exploring hypotheses about the effects of population and ecosystem processes on population dynamics, this modelling framework will improve understanding about the drivers of shifts in population productivity while serving as a transparent and robust approach to support ecosystem‐based fisheries management.