bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between NRS-2002 combined with GLIM criteria and preoperative sarcopenia in patients with gastrointestinal malignancies：A prospective cohort study
Authors: Xu Yeming , Shi Na , Zhao Yuqiu , Sun Qiannan , Gao Shuyang , Hua Mingbo , Wang Tianxiu , Wang Daorong 
Published: March 2024

Abstract

Background & Purpose
Since the Global Leadership Initiative on Malnutrition (GLIM) criteria are based on expert consensus recommendations, more clinical practice is needed to be validated. Currently, there is a lack of Nutritional Risk Screening 2002(NRS-2002) combined with the GLIM used in the diagnosis of muscle loss and malnutrition. The aim is to investigate the correlation between NRS-2002 in combination with The GLIM criteria in patients with gastrointestinal malignancies with muscle loss (sarcopenia).
Methods
In this study, we selected 210 patients with gastrointestinal malignant tumors from June 2022 to July 2023 from X Hospital. The nutritional status of the patients was assessed using the NRS-2002 and the GLIM diagnostic criteria. Patients were categorized as nutritionally normal, at nutritional risk, moderately malnourished, or severely malnourished based on the NRS-2002 in conjunction with the GLIM criteria.
Results
The prevalence of sarcopenia differed among various nutritional status groups( p < 0.01). In the moderately malnourished group and the severely malnourished group, the prevalence of sarcopenia was 36% and 83%, respectively. A positive correlation was observed between malnourishment and the presence of sarcopenia, as indicated by NRS-2002 (p < 0.001). Results from binary logistic regression analysis revealed that gender, height, ASMI, nutritional risk, and malnutrition were all risk factors for the development of sarcopenia (p < 0.05).
Conclusion
The prevalence of preoperative sarcopenia in patients with gastrointestinal malignancies is high, and there is a correlation between the NRS-2002 combined with GLIM criteria and sarcopenia in gastrointestinal malignancies.
Single Nucleotide Polymorphisms Related to Telomere Length Predispose for Coronary Heart Disease in Chinese Han Population
Authors: Liu Hanfang , Xian Xuemin , Li Changxi , Wu Xinquan , Zhao Xin , Zhang Xiuli , Miao Fei 
Published: March 2024

Abstract

To evaluate the single nucleotide polymorphisms (SNPs) related to leukocyte telomere length (LTL) whether cause susceptibility to coronary heart disease (CHD) in Chinese Han. We examined the difference of LTL and the alleles and genotypes of 14 SNPs related to LTL between 86 controls and 207 CHD subjects in Chinese Han, using binary logistic regression and Chi-square test. We confirmed that LTL was different from the two groups (r-T/S: Control 1.01 ± 0.3, CHD 0.82 ± 0.37, P < 0.001). The longer LTL was associated with lower risk of CHD, adjusted by age and gender, etc. (P = 0.001, OR = 0.278, 95% CI 0.132–0.588). To verify the effect of SNPs related to LTL on CHD risk, 14 SNPs were selected for association analysis with CHD. The minor alleles “T” of rs10069690, “A” of rs2242652 and “A” of rs7726159 on TERT were associated with a decreased CHD risk by Chi-square test (P = 0.046, OR = 0.628, 95% CI 0.397–0.994; P = 0.038, OR = 0.612, 95% CI 0.384–0.976; P = 0.026, OR = 0.663, 95% CI 0.462–0.952). The “AA” compared to “CC” of rs7726159 on TERT was associated with a decreased risk CHD risk in the addictive model adjusted by age and sex (P = 0.031, OR = 0.435, 95% CI 0.204–0.926). Our study shows that longer LTL is associated with a decreased CHD risk, and that the SNPs located on the TERT gene are associated with CHD susceptibility.
Cold saline irrigation, a novel approach, reduces the risk of postoperative urinary tract infection in retrograde intrarenal surgery
Authors: Kasahara Ryo , Kawahara Takashi , Ueki Teiichiro , Uemura Hiroji , Makiyama Kazuhide 
Published: March 2024

Abstract
Retrograde intrarenal surgery is a standard treatment for upper urinary tract stones. However, serious postoperative urinary tract infections are frequently experienced. In this study, we hypothesized that vasoconstriction caused by kidney cooling might reduce the risk of bleeding and infection during retrograde intrarenal surgery. We retrospectively analyzed 139 patients who underwent RIRS for the treatment of renal and ureteral stones at the Japanese Red Cross Hadano Hospital in Kanagawa Prefecture. Patients were classified into two groups: the HOT group in which intraoperative irrigation was performed using saline solution heated to 37°C, and the COLD group in which saline solution cooled to 4°C. The incidence of urinary tract infection after surgery was significantly lower in the COLD group (7.4%) than in the HOT group (19.7%). The length of hospital stay was also shorter in the COLD group than in the HOT group. Our results suggest that intraoperative irrigation with cooled saline may reduce the risk of perioperative UTI.
Size-dependent analytical model for the free vibration analysis of coated- functionally graded nanobeams via a nonlocal strain gradient theory and higher order shear deformation theory
Authors: Guerroudj Mohamed , Drai Ahmed , Daikh Ahmed Amine , Houari Mohammed Sid Ahmed , Eltaher Mohamed A. , Belarbi Mohamed-Ouejdi 
Published: March 2024

Abstract
Free vibration behavior of new advanced functionally graded (FG) nanobeam, namely the coated FG nanobeam, is presented in this work using the recently proposed nonlocal higher order shear deformation theory. In the present theory, the stress tensor can satisfy the parabolic variation of the shear stress distribution throughout the thickness direction and also fulfills the requirement that the shear stress on the top and bottom surfaces of the FG nanobeam is zero. Two common types of FG structures, namely, FG hardcore and FG softcore are considered here for the analysis with three schemes. Material properties of FG nanobeam are assumed to vary continuously both longitudinal and transversal directions according to a combined simple power-law distribution in terms of the volume fractions of the constituents. Governing equations of FG nanobeam with simply supported boundary conditions are derived using the proposed higher-order shear deformation plate theory. The nonlocal strain gradient theory is employed to capture the microstructure-dependent effect. The influence of the structure geometry, the gradient index and the nonlocal and length scale parameters on the vibration frequency is investigated. Finally, many new results are also reported in the current study, which will serve as a benchmark for future research.
A bibliometric analysis of the glymphatic system in cognition from 2009 to 2023
Authors: Ying Xiaoqi , Xu Jingyang , Yu Qintao , Wang Xinru , Lan Songsen , Hu Liwan , Zhang Ying , Han Dexiong 
Published: March 2024

Abstract
Background: Since the discovery of the glymphatic system in mice with clearance functions distributed throughout the brain, more and more scholars have begun to study the glymphatic system. However, there are a limited number of correlations between glymphatic system and cognition. Therefore, this study aimed to evaluate the research trends, hotspots, and frontiers of glymphatic system in cognition using bibliometric analysis.
Methods: Publications from the Web of Science Core Collection (WoSCC) database spanning 15 years from 1 January 2009 to 31 December 2023 were screened. All eligible publication were included based on our comprehensive search strategy. The analysis of annual publications, countries/regions, institutions, journals, authors, co-cited journals, co-cited authors, and keywords was conducted using CiteSpace and VOSviewer, and the hotspots and major ﬁndings of the glymphatic system in cognition were summarised. In addition, ArcGIS software was used to geovisualize the count of publications.
Results: A total of 625 publications were included in this study. Overall, the number of publications has been increasing steadily per year. These publications were published in 59 countries/regions and 149 institutions. Of these, American institutions had the highest number of publications, and their international inﬂuence also ranked first. The journal “Neurology” published the most publications and was considered the most co-cited journal. Wardlaw, Joanna M was the author of the most published articles and the most cited authors. The article entitled “The glymphatic pathway in neurological disorders” published in Lancet neurology had the most citations. The keywords with the highest number of occurrences were “Alzheimer disease” and “small vessel disease”, which were regarded as research hotspots. Three main clusters were shown in the keywords clustering network. Alzheimer's disease and perivascular spaces had been a hot topic for a long time and from 2017 research on GS increased. Among 19 emergent terms, “Virchow robin spaces”, “vascular dementia”, and “autosomal dominant arteriopathy” were the ﬁrst, and “white matter lesions” were the strongest.
Conclusion: Previous research has focused mainly on perivascular spaces, however, with the concept of the glymphatic system was introduced, the correlation of the glymphatic system in cognition have gradually increased. Currently, limited studies have been conducted on the glymphatic system in cognition , and we hope that this study will provide the recommendation for the future research.
Underlying Dynamics of PM2.5 Concentrations in China: Evidence Based on ARDL Approach
Authors: Akça Emrah Eray , Tosun Tayfun Tuncay 
Published: March 2024

Abstract
This study investigates the underlying dynamics of air pollution utilizing time series data from China over the period 2000–2020. In the empirical setting, air pollution is represented by particulate matter 2.5 (PM2.5) concentrations known as the most detrimental ambient pollutant. The empirical model of the study includes several socioeconomic potential determinants of PM2.5 concentrations. The main motivation behind the study is the downward tendency of PM2.5 concentrations in China as of the second decade of the 2000s. At this point, although it is commonly accepted that the Air Pollution Prevention and Control Action Plan implemented by the Chinese State Council has been effective, the underlying specific dynamics of reducing PM2.5 concentrations are not clear. From this motivation, the study unveiled the driving forces of PM2.5 concentrations in the framework of the autoregressive distributed lag model approach. Empirical results put forward the positive impact of economic growth, industrialization, and foreign direct investment inflows on PM2.5 concentrations, while medium- and high-tech exports, and coal rents are found negatively associated with them. In this respect, overall results particularly emphasize the lowering effect of an increase in medium- and high-tech product exports on the PM2.5 concentrations. In this context, to improve the air quality further, the study suggests that China should transform its industrialization structure toward specialization in medium- and high-tech products, and promote foreign direct investment inflows specialized in these types of products. The study provides additional policy recommendations for Chinese policymakers.
Assessing the Impacts of Future Climate Extremes on Boro Rice Cultivation in the Northeastern Haor Region of Bangladesh: Insights from CMIP6 Multi-Model Ensemble Projections
Authors: Kamruzzaman Mohammad , Islam HM Touhidul , Rahman Md. Sazzadur , Ahmed Sharif , Lipi Liala Ferdousi , Khan Md. Arifur Rahman , Tran Lam-Son Phan , Hossain AMK Zakir 
Published: March 2024

Abstract

Northeastern Bangladesh is highly vulnerable to the intensifying impacts of climate change, with extreme climatic events posing a significant threat to rice production. This study examines the projected changes in five key thermal stress indices and heavy rainfall during the rice reproductive phase using 15 global climate models (GCMs) under moderate (SSP2-4.5) and high (SSP5-8.5) emission scenarios. Statistical downscaling and bias correction techniques were employed to generate daily climate data for rainfall, maximum temperature (Tmax), and minimum temperature (Tmin). The Mann–Kendall (MMK) test was applied to identify future trends in these extreme events. The results reveal a substantial decrease in cold stress indices, with three consecutive cold days (CCD3) and six consecutive cold days (CCD6) projected to decline by approximately 9 days. Notably, heat stress indices are anticipated to increase, with hot days (HD) and consecutive hot days (CHD) rising by 18 and 11, respectively. Heavy rainfall days (HR) did not exhibit significant changes. The projected rise in temperatures above 35°C during the rice reproductive phase, encompassing critical stages such as flowering, gametophyte development, anthesis, and pollination and fertilization, suggests adverse consequences for rice yields. These findings underscore the urgency of implementing specific adaptation and mitigation measures to minimize potential yield losses in a future characterized by elevated temperatures. Such measures may include cultivating heat-tolerant rice varieties, adjusting planting windows, and diversifying rice varieties with varying growth durations.
Novel genomic variants influencing methotrexate delayed excretion in pediatric patients with acute lymphoblastic leukemia
Authors: Choi Jung Yoon , Kwon Hoshik , Kim Hyery , Hong Kyung Taek , Ma Youngeun , Koh Kyung-Nam , Yun Sunmin , Yoo Keon Hee , Song Sang Hoon , Kang Hyoung Jin , Im Ho Joon , Kim Ju Han 
Published: March 2024

Abstract
Background
Methotrexate (MTX) is the primary drug used in the treatment of pediatric acute lymphoblastic leukemia (ALL). However, some patients exhibit delayed excretion of high-dose (HD) MTX, which induces severe nephrotoxicity. We sought to identify relevant mutations associated with delayed excretion of HD-MTX in pediatric patients with ALL.
Methods
Whole-exome sequencing of germline DNA was performed in 51 Korean pediatric patients with ALL. A total of 341 HD-MTX infusion data points from 51 patients were analyzed. Correlations between peak serum MTX levels at 24 h and toxicity markers were assessed. Analyses were performed to identify variants affecting delayed MTX excretion.
Results
The 24 h MTX level strongly correlated with the subsequent Cr level. Moreover, rs2229866 in CNTN2, rs200687372 in MTMR9, rs777260512 in POLI, rs16954698 in PKD1L2, rs117765468 in NSMCE1, and rs1800956 in ENG were identified as candidate variants associated with delayed MTX excretion. In particular, ENG rs1800956 was significantly associated with delayed MTX excretion in all analyses.
Conclusions
This is the first whole-exome sequencing-based analysis of delayed MTX excretion in pediatric patients with ALL. Six candidate variants were identified, and ENG rs1800956 was identified as a novel and promising variant affecting delayed MTX excretion. Therefore, further analyses and validation are required.
A protective causal relationship between morphine and colorectal cancer: a two-way Mendelian randomization study
Authors: Deng Qing , Yu Yi fan , Yu Cheng yang , Luo Hui yan , Gong Chun , Wang Xiong Wen 
Published: March 2024

Abstract
Purpose: The relationship between morphine and colorectal cancer has been controversial. To address this controversial issue, we examined the relationship between morphine and colorectal cancer.
Methods: The causal relationship between morphine and colorectal cancer was investigated through Mendelian randomization (MR). Analysis was conducted using the publicly available GWAS database. First, single nucleotide polymorphisms (SNPs) strongly associated with morphine exposure factors were screened. Then the causal relationship between morphine and colorectal cancer was analyzed using inverse variance weighted (IVW), weighted median, and MR Egger methods. Finally, tests for sensitivity, heterogeneity, and pleiotropy were performed to ensure the stability and reliability of the results.
Result: The IVW analysis revealed a protective causal relationship between morphine use and colorectal cancer (odds ratio [OR] = 0.30, 95% confidence interval [CI]: 0.10-0.87, p = 0.03).
Conclusion: We provide evidence of a possible protective causal relationship between morphine and colorectal cancer. Further validation through larger clinical randomized studies and more advanced methods is needed.
Clinical diagnostic value of tRF-24-6VR8K09LE9 and its identification as a novel tumor suppressor in gastric cancer
Authors: Tang Yelan , Qi Qianyi , Feng Wei , Ju Shaoqing , Jing Rongrong , Zong Wei 
Published: March 2024

Abstract
Background
One of the most common gastrointestinal tumors is gastric cancer (GC), which has a high lethality and a poor prognosis. Traditional markers are relatively limited in detecting the development and prognosis of GC. Recently, it was discovered that mature tRNAs, which are expressed differently in a variety of malignancies, give rise to a novel class of tRNA-derived small RNAs (tsRNAs).
Methods
In this study, we investigated the role of short RNAs produced from tRNA in GC and possible therapeutic uses. We performed the detection of three tsRNAs using the tsRFun database, and then the TCGA database and quantitative real-time PCR (qRT-PCR) were applied to validate them. Sanger sequencing, agarose gel electrophoresis, and several freeze-thaw experiments have been utilized to assess its performance at room temperature. The association between tRF-24-6VR8K09LE9 and clinicopathological features was investigated by the Chi-square test. Diagnostic effectiveness is assessed by Receiver operating characteristic curves (ROC). Furthermore, mechanistic studies were performed to verify the effects of tRF-24-6VR8K09LE9 in GC.
Results
In GC, tRF-24-6VR8K09LE9 is low expressed. The Chi-square test displayed that tRF-24-6VR8K09LE9 was highly related to differentiation grade (P = 0.029), T-stage (P = 0.036), lymph node status (P = 0.036), TNM staging (P < 0.0001), and neurological/vascular invasion (P = 0.033), and the ROC curve indicated that tRF-24-6VR8K09LE9 is more effective than the current diagnostic markers for GC. Furthermore, mechanistic studies verified that upregulation of tRF-24-6VR8K09LE9 inhibited the development of GC.
Conclusions
tRF-24-6VR8K09LE9 can serve as a molecular marker for early GC. tRF-24-6VR8K09LE9 may be a tumor suppressor, and high levels of tRF-24-6VR8K09LE9 GC inhibit the invasion and migration.
Haemodynamic Effect of Dexmedetomidine During Pediatric Kidney Transplantation: A Single-Center Retrospective Study
Authors: Monteil Matéo , Chenouard Alexis , Roussey Gwenaëlle , Bernardon Rémi , Gaultier Aurélie , Porcheret Florence 
Published: March 2024

Abstract

Background Dexmedetomidine is increasingly used for its hemodynamic stability property during general anesthesia. However, there is no data on pediatric kidney transplant recipients (pKTR). Our study investigates the hemodynamic effect of perioperatively administered dexmedetomidine in pKTR. Methods Between 2019 and 2023, all pKTR below 18 years were studied retrospectively at Nantes University Hospital. Intraoperative hemodynamic status was compared between patients who had received dexmedetomidine during kidney transplantation (DEX group) and patients who had not (no-DEX group). Mean arterial pressure (MAP) and heart rate (HR) were monitored throughout the duration of anesthesia and compared. Graft function was assessed by creatinine levels and Glomerular Filtration Rate (GFR) at specific time points. The use of fluid and vasoactive drugs peri-operatively and within 24 hours after surgery was also studied. Results 38 patients were included, 10 in the DEX group et 28 in the no-DEX group. Intraoperative HR was similar between the two groups; however, MAP was significantly higher (mean difference 8, standard deviation [SD: 2–14] mmHg,p = 0,034) in the DEX group. No differences were found regarding the use of fluid and vasoactive drug therapy between groups. Glomerular filtration rate at one month was significantly higher in DEX group (p = 0,009). Conclusion Children receiving intraoperative dexmedetomidine during a KT presented higher perioperative MAP compare to children receiving other sedative agents. DEX group also showed better graft function at one month. The direct impact of dexmedetomidine on immediate post-operative graft function in pTKR should be studied in a prospective multicenter randomized study.
Intraoperative radiotherapy after neurosurgical resection of brain metastases as institutional standard treatment– Update of the oncological outcome form a single center cohort after 117 procedures
Authors: Kahl Klaus-Henning , Krauss Philipp E. , Neu Maria , Maurer Christoph J. , Schill-Reiner Sabine , Roushan Zoha , Laukmanis Eva , Dobner Christian , Janzen Tilman , Balagiannis Nikolaos , Sommer Björn , Stüben Georg , Shiban Ehab 
Published: March 2024

Abstract

Purpose: Stereotactic radiotherapy (SRT) is the predominant method for the irradiation of resection cavities after resection of brain metastases (BM). Intraoperative radiotherapy (IORT) with 50kV x-rays is an alternative way to irradiate the resection cavity focally. We have already reported the outcome of our first 40 IORT patients treated until 2020. Since then, IORT has become the predominant cavity treatment in our center due to patients´ choice.
Methods: We retrospectively analyzed the outcomes of all patients who underwent resection of BM and IORT between 2013 and August 2023 at Augsburg University Medical Center (UKA).
Results: We identified 105 patients with 117 resected BM treated with 50kV x-ray IORT. Median diameter of the resected metastases was 3.1cm (range 1.3 – 7.0 cm). Median applied dose was 20Gy. All patients received standardized follow-up (FU) including three-monthly MRI of the brain. Mean FU was 14 months, with a median MRI FU for patients alive of nine months. Median overall survival (OS) of all treated patients was 18.2 months (estimated 1-year OS 57.7%). The observed local control (LC) rate of the resection cavity was 90.5% (estimated 1-year LC 84.2%). Distant brain control (DC) was 61.9% (estimated 1-year DC 47.9%). Only 16.2% of all patients needed WBI in the further course of disease. The observed radio necrosis rate was 2.6%.
Conclusion: After 117 procedures IORT still appears to be a safe and appealing way to perform cavity RT after neurosurgical resection of BM with low toxicity and excellent LC.
Statistic Deviation Mode Balancer (SDMB): A novel sampling algorithm for imbalanced data
Authors: Alimoradi Mahmoud , Daliri Arman , Zabihimayvan Mahdieh , Sadeghi Reza 
Published: March 2024

Abstract

Proper grouping in classifier algorithms is a critical element of supervised learning. The first step in this is to have the correct data. Data that has a problem is worse than not having it. One of the biggest problems inherent in natural data is its imbalance. For a classifier algorithm to achieve its best performance, the first step is to fix the problem of data imbalance. To work with real datasets, the first step is to balance the data. The main problem with existing algorithms is to duplicate minority data and generate data that make outlines part of the primary data. The Statistic Deviation Mode Balancer (SDMB) algorithm solves this problem by making samples that adhere to the original data structure. Our proposed algorithm generates data that is very similar to the original data with the help of standard deviation and the amount of minor data mode and moving away from the majority part. Using these two parameters, the SDMB algorithm avoids Outlier data and generates clean data. The output of this algorithm is a balance datasheet that helps classifier algorithms learn the best way from the data. Different classifier algorithms with entirely different methods have been tested to prove this point. First, we balanced the different datasets with our method. Then, with varying classifier algorithms, we compared it with other existing algorithms. This experiment showed that our proposed algorithm is superior to other competitors and can be used in the work process of real datasets.