bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased plasminogen activator inhibitor-1, decreased tissue factor pathway inhibitor, and unchanged thrombin-activatable fibrinolysis inhibitor levels in patients with primary hyperparathyroidism
Authors: Erem Cihangir , Kocak Mustafa , Nuhoglu İrfan , Yilmaz Mustafa , Ucuncu Ozge 
Published: February 2009

Background and objectivesPrimary hyperparathyroidism (PHPT) is associated with increased cardiovascular mortality and morbidity. Little is known about hemostatic features of patients with PHPT. To our knowledge, plasma tissue factor pathway inhibitor (TFPI) and thrombin-activatable fibrinolysis inhibitor (TAFI) levels in these patints have not been investigated. Therefore, the main purpose of this study was to evaluate the markers of endogenous coagulation/fibrinolysis, including TFPI and TAFI, and to investigate the relationships between serum calcium and PTH and these hemostatic parameters in patients with PHPT.Design and methodsTwenty-four patients with PHPT and 20 age-, sex-, and-weight-matched healthy controls were included in the study. Tissue plasminogen activator (t-PA), tissue plasminogen activator inhibitor-1 (PAI-1), TFPI, and TAFI were measured. The relationships between serum calcium, phosphorus, and PTH and these hemostatic parameters were examinated.ResultsCompared with the control subjects, t-PA, PAI-1, and PAI-1/t-PA ratios were significantly increased in patients with PHPT (P<0.0001), whereas TFPI levels were significantly decreased (P<0.0001). Plasma TAFI Ag levels did not significantly change in patients with PHPT compared with the controls. In patients with PHPT, serum phosphorus was negatively correlated with plasma PAI-1 Ag levels and PAI-1/t-PA ratio (r: −0.453,P<0.05;r: −0.580,P<0.01 respectively). There was a positive correlation between Cl/P ratio and plasma PAI-1 levels and PAI-1/t-PA ratio (r: 0.434,P<0.05;r: 0.528,P<0.05 respectively). iPTH was positively correlated with plasma PAI-1/t-PA ratio (r: 0.429,P<0.05).Interpretation and conclusionsIn conclusion, we found some important differences in the hemostatic parameters between the patients with PHPT and healthy controls. Increased PAI-1, PAI-1/t-PA ratios and decreased TFPI levels in these patients represent a potential hypercoagulable and hypofibrinolytic state, which might augment the risk for atherosclerotic and atherothrombotic complications. This condition may contribute to the excess mortality due to cardiovascular disease seen in patients with PHPT.
Reconfigurable Logic Gates Capable of Device‐Level Parallel Processing Through Multi‐Input Synaptic Device
Authors: Roe Dong Gue , Park Sung Hyeon , Jeong Sang Young , Choi Yoon Young , Ahn Jong‐Hyun , Woo Han Young , Cho Jeong Ho 
Published: April 2024

AbstractSynaptic devices have gained prominence as viable alternatives to conventional complementary metal‐oxide‐semiconductor‐based (CMOS) electronics in the information processing field owing to their inherent advantages in analog and parallel operations. The potential of synaptic devices has not yet been fully utilized for logic operations because only the conventional binary logic structure has been applied to analog synaptic devices, leading to the loss of advantages unique to analog signals. To resolve this issue, an innovative concept is proposed: an analog logic gate that can perform parallel operations at the device level and is coupled with logic reconfigurations, enabling comprehensive analog computation. This logic gate comprises two synaptic devices with different retention characteristics, adjusted by the side‐chain engineering of an organic polymer. The long‐term and short‐term synaptic devices serve as reconfigurable synapse for logic mode selection and parallel processable logic synapse, respectively. In this study, the reconfigurable and parallel processable synaptic logic circuit is effectively implemented in a personalized disease risk diagnostic system. This innovative approach not only allows for the simultaneous computation of analog‐formed diagnostic data, but also enhances both computing efficiency and system complexity in general synaptic systems.
Design Principles of Diketopyrrolopyrrole‐Thienopyrrolodione Acceptor1–Acceptor2 Copolymers
Authors: Erhardt Andreas , Hungenberg Julian , Chantler Paul , Kuhn Meike , Huynh Thanh Tung , Hochgesang Adrian , Goel Mahima , Müller Christian J. , Roychoudhury Subhayan , Thomsen Lars , Medhekar Nikhil V. , Herzig Eva M. , Prendergast David , Thelakkat Mukundan , McNeill Christopher R. 
Published: April 2024

AbstractThe design principles of acceptor1–acceptor2 copolymers featuring alternating diketopyrrolopyrrole (DPP) and thienopyrrolodione (TPD) moieties are investigated. The investigated series of polymers is obtained by varying the aromatic linker between the two acceptor motifs between thiophene, thiazole, pyridine, and benzene. High electron affinities between 3.96 and 4.42 eV, facilitated by the synergy of the acceptor motifs are determined with optical gaps between 1.37 and 2.02 eV. Grazing incidence wide‐angle X‐ray scattering studies reveal a range of film morphologies after thermal annealing, including face‐on, end‐on and superstructure edge‐on‐like crystallites. Conversely, all materials form thin edge‐on layers on the polymer–air interface, as demonstrated by multi‐elemental near‐edge X‐ray absorption fine‐structure spectroscopy. The benefit of the electron‐deficient linkers thiazole and pyridine is evident: In organic field effect transistors, electron mobilities of up to 4.6 × 10−2 cm2 V−1 s−1 are obtained with outstanding on/off current ratios of 5 × 105, facilitated by the absence of detectable hole transport in these materials. Viability for all‐polymer solar cells is assessed in active layer blends with the donor polymer PM6, yielding a maximum average power conversion efficiency of 4.8% and an open circuit voltage above 1 V.
Te nanomesh/black‐Si van der Waals Heterostructure for High‐Performance Photodetector
Authors: Wei Yiyang , Lan Changyong , Zeng Ji , Meng You , Zhou Shuren , Yip SenPo , Li Chun , Yin Yi , Ho Johnny C. 
Published: April 2024

AbstractVan der Waals (vdW) heterostructures have gained significant attention in photodetectors due to their seamless integration with materials possessing diverse functionalities. In this study, the fabrication of a Te nanomesh/black‐Si vdW heterostructure is presented, and investigated its photoresponse properties. The heterostructure exhibits a pronounced rectification behavior, characterized by a rectification ratio of 2.2 × 104. Notably, the heterostructure device demonstrates commendable photoresponse properties, including a high responsivity of 350 mA W−1, an extensive linear dynamic range of 45.5 dB, a high specific detectivity of 9.6 × 1011 Jones, and a wide spectral response ranging from 400 to 1550 nm. Furthermore, the heterostructure exhibits rapid response, with a rise time and a decay time of 70 and 140 µs, respectively. These exceptional photoresponse properties can be attributed to the robust internal built‐in electrical field at the hetero‐interface and the augmented light absorption in black‐Si. The outstanding photoresponse properties of the heterostructure make it a promising candidate for multiwavelength single‐pixel imaging, enabling the collection of mask patterns under varying wavelengths of light radiation. This work provides a novel approach for fabricating mixed‐dimensional vdW heterostructures, offering promising prospects for advancements in optoelectronics.
Homogeneous and Significant Near‐Field Enhancement in All‐Dielectric Metasurfaces for Sensing Applications
Authors: Li Guangyuan , Liu Yunhui 
Published: April 2024

AbstractAll‐dielectric metasurfaces supporting high‐Q resonances have emerged as a promising platform for sensing applications. However, the greatly enhanced near‐fields are usually confined within the all‐dielectric nanostructures rather than the outside analyte region, severely limiting the bulk sensitivity and the biosensing performance. Here, a silicon metasurface formed by the hybridization of two lattices with a relative displacement is designed to support nonlocal quasi‐bound states in the continuum (q‐BICs) featuring homogeneous and significant near‐field enhancement over large volumes outside the silicon nanodisks. A high bulk sensitivity of 407 nm RIU–1 is experimentally demonstrated for the refractive index sensing applications, and a limit of detection down to 20 pg mL–1 for a protein biomarker for the early‐stage breast cancer screening, which is improved by more than an order of magnitude over the state of the art. It is expected that the nonlocal q‐BICs open new opportunities for realizing greatly enhanced light–matter interactions over large volumes in applications beyond biochemical sensing.
Fabrication of Translucent and Chemically Durable Crystal‐Glass Composite with Multicolor Persistent Luminescence
Authors: Mohamed Moushira. A. , Ali Mohamed. A. , Shaorun Guo , Liu Xiaofeng , Qiu Jianrong 
Published: April 2024

AbstractLong persistent luminescence materials (LPLMs) are promising candidates for various photonic applications, owing to their ability to store light. In spite of advancements in exploring of new LPLMs, the fabrication of transparent centimeter‐sized LPLMs with pre‐designed shapes, high productivity, long afterglow multicolor luminescence, and high chemical stability, is still challenging. Here, high‐throughput manufacture of translucent crystal‐glass composites via a classical injection molding (IM) technique is demonstrated, in which persistent phosphors (PPs)‐amorphous silica nanoparticles‐polymer composites are molded into different shapes then thermally treated at elevated temperatures to obtain glass composites with embedded PP particles and customized shapes. The structural characterizations endorse that the PP particles are preserved during high temperature sintering, and the resultant crystal‐glass composites combine the unique benefits of both PPs and silica glass. Remarkably, the total production time to manufacture 100 pieces of centimeter‐sized crystal‐glass composites is 35 h, thus enabling high‐throughput production of glass composite articles by the IM method. In addition, the injection molded crystal‐glass composites demonstrate long afterglow multicolor luminescence and ultrahigh chemical durability. This study provides a massive production strategy for the fabrication of translucent and stable multicolor persistent luminescent objects with customized shapes, which can be used in numerous applications.
Access to Benzyl Oxindoles via Electron Donor‐Acceptor Complex Photoactivation Using Thianthrenium Salts and Potassium Carbonate
Authors: Sarró Pau , Gallego‐Gamo Albert , Pleixats Roser , Vallribera Adelina , Gimbert‐Suriñach Carolina , Granados Albert 
Published: April 2024

AbstractA photochemical synthesis of biologically relevant benzyl oxindoles is presented via electron‐donor acceptor (EDA) complex strategy. This exogenous photocatalyst‐free method describes the formation of a new electron donor‐acceptor complex based on potassium carbonate and thianthrenium salts for C(sp2)−C(sp3) bond formation. This transition‐metal free reaction allows a rapid increase in oxindoles molecular complexity chemical space, tolerating different functional groups as well as sophisticated biomolecules. The scalability and sustainability of this method is highlighted by an important waste recovery protocol. Mechanistic investigations support the formation of an EDA complex that induces a radical chain, and the applicability of this method is showcased by straightforward derivatization reactions.
NIR‐II Fluorescence Sensor Based on Steric Hindrance Regulated Molecular Packing for In Vivo Epilepsy Visualization
Authors: Zhao Mengyao , Lai Weiping , Li Benhao , Bai Tianwen , Liu Chunyan , Lin Yanfei , An Shixuan , Guo Longhua , Li Lei , Wang Jianbo , Zhang Fan 
Published: April 2024

AbstractFluorescence sensing is crucial to studying biological processes and diagnosing diseases, especially in the second near‐infrared (NIR‐II) window with reduced background signals. However, it's still a great challenge to construct “off‐on” sensors when the sensing wavelength extends into the NIR‐II region to obtain higher imaging contrast, mainly due to the difficult synthesis of spectral overlapped quencher. Here, we present a new fluorescence quenching strategy, which utilizes steric hindrance quencher (SHQ) to tune the molecular packing state of fluorophores and suppress the emission signal. Density functional theory (DFT) calculations further reveal that large SHQs can competitively pack with fluorophores and prevent their self‐aggregation. Based on this quenching mechanism, a novel activatable “off‐on” sensing method is achieved via bio‐analyte responsive invalidation of SHQ, namely the Steric Hindrance Invalidation geNerated Emission (SHINE) strategy. As a proof of concept, the ClO−‐sensitive SHQ lead to the bright NIR‐II signal release in epileptic mouse hippocampus under the skull and high photon scattering brain tissue, providing the real‐time visualization of ClO− generation process in living epileptic mice.
Reaction Environment Regulation for Electrocatalytic CO2 Reduction in Acids
Authors: Zeng Min , Fang Wensheng , Cen Yiren , Zhang Xinyi , Hu Yongming , Xia Bao Yu 
Published: April 2024

AbstractThe electrocatalytic CO2 reduction reaction (CO2RR) is a sustainable route for converting CO2 into value‐added fuels and feedstocks, advancing a carbon‐neutral economy. The electrolyte critically influences CO2 utilization, reaction rate and product selectivity. While typically conducted in neutral/alkaline aqueous electrolytes, the CO2RR faces challenges due to (bi)carbonate formation and its crossover to the anolyte, reducing efficiency and stability. Acidic media offer promise by suppressing these processes, but the low Faradaic efficiency, especially for multicarbon (C2+) products, and poor electrocatalyst stability persist. The effective regulation of the reaction environment at the cathode is essential to favor the CO2RR over the competitive hydrogen evolution reaction (HER) and improve long‐term stability. This review examines progress in the acidic CO2RR, focusing on reaction environment regulation strategies such as electrocatalyst design, electrode modification and electrolyte engineering to promote the CO2RR. Insights into the reaction mechanisms via in situ/operando techniques and theoretical calculations are discussed, along with critical challenges and future directions in acidic CO2RR technology, offering guidance for developing practical systems for the carbon‐neutral community.
Synthesis and evaluation of PVC‐Cu/Al2O3 nanocomposite membranes for removing of natural organic matter from the wastewater
Authors: Sajjadi Seyed Mehdi , Etemadi Habib , Zaremanesh Masoumeh 
Published: April 2024

AbstractThe synthesis of Cu/Al2O3 nanoparticles (NPs) was conducted by the citric acid sol–gel technique. We used the synthesized NPs to enhance PVC membranes and create PVC‐Cu/Al2O3 nanocomposite membranes. The quantities of NPs utilized were 0, 0.5, 1, 1.5, and 2 wt.% of solid phase. The point of this study was to look into how PVC‐Cu/Al2O3 membranes can be used to remove natural organic matter (NOM) from polluted water in submerged membrane systems. The membranes treated with NPs exhibited increased porosity, improved hydrophilicity, and smoother surface. Results revealed that the incorporation of 1 wt.% NPs into PVC (PVC‐CA1) demonstrated the highest degree of hydrophilicity and porosity. Moreover, PVC‐CA1 exhibited an increased number of pores, with larger pores present on the top surface and larger macrovoids on the cross‐sectional surface. The PVC‐CA1 exhibited the highest flux recovery ratio (FRR) and highest rejection rate for HA, with values of 82.6% and 92.6%, respectively. PVC‐CA1, which had an irreversible fouling ratio (IFR) of 17.3%, demonstrated the greatest resistance to fouling. Generally, incorporation of NPs into PVC resulted in increased hydrophilicity, enhanced porosity, uniform dispersion, smoother surface characteristics, and consequently improved antifouling properties. Furthermore, among the fabricated membranes, PVC‐CA1 had the most favorable antifouling performance.
Sea turtle bycatch in Argentina: A qualitative assessment in commercial vessels
Authors: Jones Sofía , Calvo Rodrigo , Rolón Melisa Celia Jazmin , Tettamanti Germán , Vera David Gustavo , Prosdocimi Laura 
Published: April 2024

Abstract1. The Northern Argentine continental shelf is a sea turtle feeding ground that overlaps with important fisheries. Few studies assessed bycatch impact, especially on commercial vessels. 2. This work documents sea turtles' bycatch, fishery involved, species captured and crew actions. 3. Bycatch in four fisheries were registered at the 107 interviews to fishers conducted between 2021 and 2023, showing the urgency to research bottom trawling for demersal multi‐species. Fishers frequently recognize Caretta caretta, and positive and negative practices towards animals have been documented on‐board. 4. These results will help focus researches on fisheries with the greatest impact on sea turtles in the region. They also underscore the necessity for implementing commercial vessel monitoring programmes and improving on‐board handling practices.
Ehren und Erinnern (re‐)konstruieren – ein Kommentar.
Authors: Pinwinkler Alexander 
Published: April 2024

AbstractThe commentary interprets the practices of remembering and the creation of memory as an attempt at academic and public‐media self‐understanding, which exhibit past‐political, present‐oriented and future‐oriented perspectives and intentions. Academic politics of history and remembrance can hardly be imagined without reference to and interaction with the public and politics. The contributions in this special issue make it clear that a large number of public and private actors and interest groups are usually involved in memory policy controversies surrounding academics. When discussing prizes, street names or school names named after academics, for example, very different logics and ideas about remembering and memory often clash. This fundamental dilemma is particularly evident in debates about controversial academics who worked before, during and after the Nazi era.
Meeting the closed‐loop challenge: The “Who‐What‐How” strategic choices for a successful remanufacturing approach
Authors: Pesce Danilo , Franzè Claudia , Paolucci Emilio 
Published: April 2024

AbstractRemanufacturing is a life‐cycle renewal process recognised as one of the most effective circular strategies that can be adopted to achieve sustainable production. However, its potential has been hindered by the absence of an integrated perspective across various business domains to catalyse successful remanufacturing efforts. This paper aims to explore how such an integrated perspective can facilitate the creation of sustainable value within remanufacturing business models. To fill this gap, an in‐depth longitudinal case study was conducted on how remanufacturing practices can be effectively implemented in the white goods sector. The research identifies four fundamental mechanisms that, when used synergistically, pave the way for a successful remanufacturing approach yielding triple‐bottom‐line benefits. The study contributes to the remanufacturing literature by illustrating how (i) moving from products to solutions that fulfil customer priorities, (ii) resequencing business processes according to customer‐oriented logic, (iii) enhancing the clock‐speed of decision‐making and (iv) sharing risks within the supply chain, can unveil new strategic positioning for sustainable value creation. From a practical perspective, it advocates for the adept management of remanufacturing uncertainties through continuous, active questioning of “Who‐What‐How” choices and the cultivation of circular and organic interdependencies.
Role of extracellular vesicles in insulin resistance: Signaling pathways, bioactive substances, miRNAs, and therapeutic potential
Authors: Zhang Wang , Song Mengdi , Fang Zhou , Chen Feng , Yuan Hui , Gao Xinran , Liu Kehai 
Published: April 2024

AbstractExtracellular vesicles are small lipid bilayer particles that resemble the structure of cells and range in size from 30 to 1000 nm. They transport a variety of physiologically active molecules, such as proteins, lipids, and miRNAs. Insulin resistance (IR) is a pathological disease in which insulin‐responsive organs or components become less sensitive to insulin's physiological effects, resulting in decreased glucose metabolism in target organs such as the liver, muscle, and adipose tissue. Extracellular vesicles have received a lot of attention as essential intercellular communication mediators in the setting of IR. This review looks at extracellular vesicles' role in IR from three angles: signaling pathways, bioactive compounds, and miRNAs. Relevant publications are gathered to investigate the induction, inhibition, and bidirectional regulation of extracellular vesicles in IR, as well as their role in insulin‐related illnesses. Furthermore, considering the critical function of extracellular vesicles in regulating IR, the study analyzes the practicality of employing extracellular vesicles for medication delivery and the promise of combination therapy for IR.
A Platinum‐Aluminum Bimetallic Salen Complex for Pro‐senescence Cancer Therapy
Authors: Tang Juan , Yang Yahui , Yin Hao‐Yan , Ma Bin , Zhu Mengliang , Yang Zi‐Shu , Peng Xin‐Xin , Jia Feifei , Zhao Yao , Wang Fuyi , Chen Tianfeng , Zhang Jun‐Long 
Published: April 2024

AbstractCell senescence is defined as irreversible cell cycle arrest, which can be triggered by telomere shortening or by various types of genotoxic stress. Induction of senescence is emerging as a new strategy for the treatment of cancer, especially when sequentially combined with a second senolytic drug capable of killing the resulting senescent cells, however severely suffering from the undesired off‐target side effects from the senolytic drugs. Here, we prepare a bimetalic platinum‐aluminum salen complex (Alumiplatin) for cancer therapy‐a combination of pro‐senesence chemotherapy with in situ senotherapy to avoid the side effects. The aluminum salen moiety, as a G‐quadruplex stabilizer, enhances the salen's ability to induce cancer cell senescence and this phenotype is in turn sensitive to the cytotoxic activity of the monofunctional platinum moiety. It exhibits an excellent capability for inducing senescence, a potent cytotoxic activity against cancer cells both in vitro and in vivo, and an improved safety profile compared to cisplatin. Therefore, Alumiplatin may be a good candidate to be further developed into safe and effective anticancer agents. This novel combination of cell senescence inducers with genotoxic drugs revolutionizes the therapy options of designing multi‐targeting anticancer agents to improve the efficacy of anticancer therapies.