bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term inhibition of lysosomal glucocerebrosidase activity promotes GPX4 stability and inhibits ferroptosis in a Parkinson’s model
Authors: Bonte Marie-Amandine , Gouel Flore , Jonneaux Aurélie , Belarbi Karim , Devos David , Devedjian Jean-Christophe 
Published: February 2024

Abstract
An increasing number of studies indicate that ferroptosis, a lethal pathway initiated by excessive iron-dependent lipid peroxidation, and pivotal to the survival of dopaminergic neurons and the progression of Parkinson’s disease (PD), may be regulated by the lysosomal pathway. Mutation and loss of function of the lysosomal enzyme, glucocerebrosidase, induce the accumulation of glycosphingolipids and alterations in lysosome activity, which have been associated with a higher risk of developing PD. Our present study showed that transient inhibition of glucocerebrosidase activity had a positive effect on lipid peroxidation and ferroptosis. In a dopaminergic cell line (LUHMES cells), it was shown that a 10-day inhibition of glucocerebrosidase activity using conduritol-beta-epoxide (CBE) specifically impeded susceptibility to RSL3-induced ferroptosis, but not to several other inducers of cell death. CBE impaired the lysosomal pathway, modified lipid membrane composition by reducing ether-linked phospholipids in phosphatidylethanolamines, and promoted an increase in glutathione peroxidase 4 (GPX4) protein levels. This phenomenon was transient and disappeared after 20 days of glucocerebrosidase inhibition, suggesting that the cells have the capacity to return to their basal homeostasis. Most of the current compounds acting on GPX4 promote its degradation, thus information on drugs leading to GPX4 stability is key in order to protect neurons against excessive lipid peroxidation occurring in neurodegenerative diseases.
SlMYB41 induced by exogenous brassinosteroids negatively regulates the cold resistance of tomato
Authors: Nie Shuming , Yang Zaijun , Zeng Qiaoyi , Wang Dan 
Published: February 2024

Abstract

Brassinosteroids regulate plant development and response to stress. This study demonstrated that exogenous brassinosteroid application can increase plant cold-stress tolerance. However, the effects of exogenous brassinosteroids on the cold resistance of tomatoes require further investigation. Our results indicated that exogenous 24-epibrassinolide application increased brassinosteroid content and cold resistance in tomato (Solanum lycopersicum cv. Micro-Tom) plants. RNA-seq results showed that the expression of most genes encoding proteins in photosystems I and II and photosynthetic characteristics were downregulated and that the degree of downregulation in brassinosteroid-treated plants was weaker than that in untreated (MT) plants. Furthermore, the net photosynthetic rate and maximum photochemical efficiency of brassinosteroid-treated plants were significantly higher than those of MT plants under chilling stress. Chilling stress also regulated the expression levels of 60 transcription factors. The expression of 34 genes was downregulated, and 26 were upregulated. The degree of regulation in the brassinosteroid-treated plants was lower than in the MT plants. RNA-seq results showed that brassinosteroids induced SlMYB41 expression and rapidly so during cold stress. In addition, the degree of wilting was more severe in SlMYB41 overexpression plants than in MT plants under chilling stress. Additionally, the relative electrolyte leakage and malondialdehyde content in SlMYB41OE plants were significantly higher than in MT plants. The contents of O2− and H2O2 in MT plants were significantly lower than those in SlMYB41OE plants after chilling stress. The activities of SOD, POD and CAT were significant higher in MT plants than in SlMYB41OE plants. Expression levels of four cold-responsive genes were significantly lower in SlMYB41OE plants than in MT plants after chilling stress. These results indicated that SlMYB41 overexpression reduced chilling tolerance. Therefore, the increase of plant cold resistance by application brassinosteroid is not achieved through SlMYB41.
Thinness and Muscularity-Oriented Eating Disorder Symptoms: Investigating Body Image Concerns and the Moderating Role of Emotion Dysregulation in Cyclists
Authors: Mazaraki Jack , Bussey Kay , Cunningham Mitchell , Jewell Tom , Trompeter Nora 
Published: February 2024

Abstract

Objective
A lean muscular body of low weight is often associated with performance for cyclists and can be difficult to achieve. In the pursuit of performance, eating disorder symptomatology may be experienced. Further, the training that some cyclists engage in may aid in the reduction and management of negative emotional states that arise from body dissatisfaction. While research in athlete populations has been substantial, eating disorder symptoms in cyclists remain a relatively under-explored topic. The current study examined whether shape and weight concern and drive for leanness were associated with thinness and muscularity-oriented eating disorder symptoms and whether these relations were moderated by emotion dysregulation. Interactions between these factors were also investigated.
Method
Participants were 139 Australian competitive cyclists (112 males, 27 females, aged 18–68 years) who completed a self-report questionnaire comprised of measures of shape and weight concern, drive for leanness, thinness-oriented eating, muscularity-oriented eating and emotion dysregulation variables.
Results
Shape and weight concern and drive for leanness both had a unique association with thinness-oriented and muscularity-oriented eating scores. Emotion dysregulation was found to have a unique association with thinness-oriented and muscularity-oriented eating scores when controlling for drive for leanness, but not when shape and weight concern was controlled. Additionally, emotion dysregulation moderated the association between shape and weight concern and muscularity-oriented eating scores, whereby the relationship was intensified at higher levels of emotion dysregulation.
Discussion
Our study has extended the literature by indicating that cyclists' desire to attain a lean muscular body of low weight is associated with eating disorder symptoms. Further, emotion dysregulation moderated this link, suggesting it could be a maintaining factor worth addressing.
WITHDRAWN: A Novel Approach for Intrusion Detection System based on Adaptable Variable Homomorphic Mac for Network Coding Enabled Small Cells
Authors: Nabi Faisal , Maple Carsten , Zhou Xujuan 
Published: February 2024

Abstract
For 5G networks, which can cover metropolitan regions by being installed on demand across all devices, anywhere, at any time, network coding-enabled mobile small cells are seen as a viable solution. Since intermediary nodes might alter packets while they are in route, pollution attacks present a security risk. Discovering infected packets is inevitable. Transport packets can be altered by means of the intermediary nodes. At the receiver's end, incorrect decoding will inevitably result in the detection of tainted packets. In an environment with NC enabled tiny cells, a newly proposed MAC based intrusion detection system efficiently identifies tainted packets.
Machine Learning-Based Intelligent Localization Technique for Channel Classification in Massive MIMO
Authors: Ghrabat Fadhil , Zhu Huiling , Wang Jiangzhou 
Published: February 2024

Abstract

The widespread adoption of wireless communication has led to a rapid increase in the utilization of Multiple-Input-Multiple-Output (MIMO) technology. This advancement enables the simultaneous transmission of multiple data streams through the use of multiple transmitters and receivers. MIMO leverages the radio wave phenomenon known as multipath, where transmitted signals encounter various obstacles, arriving at the antenna at different angles and times. In 5G networks, an inherent challenge in Massive MIMO Localization arises from the non-line-of-sight (NLOS) problem. This issue significantly hampers positioning accuracy, emphasizing the need for innovative solutions. This work proposes an intelligent localization technique based on NLOS identification and mitigation. To achieve this, we first propose a Convolutional Neural network (CNN) based hybrid Archimedes based Salp Swarm Algorithm (HASSA) technique to detect the NLOS and LOS and therein estimate the location accuracy. The accuracy can be analyzed by considering the angle of arrival of signals (AOA), Threshold-based Time of arrival (TOA), Time difference of arrival (TDOA) from different antennas. Henceforth, a novel Reinforcement Learning based optimization approach is used for the mitigation of NLOS in the radio wave propagation path. We use Ensemble Deep Deterministic Policy Gradient-based approach (EDDPG) based Honey Badger algorithm (HBA) for the aforementioned process. This also reduces the computational complexity. Simulation of this approach deems different scenarios and considers different parameters and compared with different state-of-art works. From the simulation results, we observed that our proposed approach can be used for the identification and detection of the LOS and NLOS components and also precisely enhance the localization than the other approaches.
Design, Development and Testing of an Ultra-Compact Antenna with Enhanced Gain for Wireless Sensor Nodes
Authors: c mohan , s esther florence 
Published: February 2024

Abstract
In this paper, a highly miniaturized monopole-like patch antenna for wireless sensor nodes with an enhanced gain is proposed. To mitigate the issue of low gain while designing a low-profile antenna for sensor nodes, the designed square shape planar antenna is employed with the symmetric modified Swastika-shaped Electromagnetic Bandgap (EBG) structure. The overall size of the proposed antenna is 0.116 𝜆 0 × 0.116𝜆0. Miniaturization of the antenna is obtained by introducing the partial ground and the slots in the radiating patch. The simulation result indicates the proposed antenna has a gain of -3.62 dB at 2.4 GHz. Further, on employing the proposed EBG reflector beneath the antenna, the peak gain is increased by 4.7 dB. The combinational structure of the EBG reflector is a 6 × 4 array and the antenna operates with a peak gain of 1.54 dB. The measurements show that the fabricated antenna has good radiation performance, high gain, and good matching with simulated results. To validate the proposed antenna, a fabricated prototype is tested and analyzed using the sensor node in a real-time environment. Based on this analysis, the proposed antenna is found to be a good candidate for sensor node applications.
Two out of five babies are born through c-section in Bangladesh: an urgent call for healthcare policy reforms
Authors: Hossain Md. Jubayer , Shahjahan Muhibullah , Hassan Md. Mahadi 
Published: February 2024

Abstract
Background
Caesarean delivery plays a significant role in reducing both maternal and child mortality rates. However, overuse of this method can have negative health consequences. This study aimed to provide evidence-based recommendations for healthcare policy reform using the Bangladesh Sample Vital Statistics 2022 report from the Bangladesh Bureau of Statistics (BBS).
Methods
This study utilized secondary data from the Sample Vital Registration System (SVRS) 2022 obtained from the Bangladesh Bureau of Statistics (BBS). The SVRS, established in 1980, collects data on vital events, such as births, deaths, marriages, and migrations, providing crucial demographic indicators for policy and research. Access to SVRS 2022 data was obtained from the official BBS website, focusing specifically on cesarean deliveries recorded in Bangladesh in 2022. The statistical analysis employed Descriptive statistics, including frequencies and percentages, were used to summarize cesarean delivery rates, geographic location, healthcare facility type, education level, and wealth quintile.
Results
Two out of five babies are currently born through cesarean section in Bangladesh, posing significant maternal and child health concerns. Most of the c-section cases (85%) occurred in private health facilities. The findings of this study revealed variations in delivery methods across different regions and settings. While rural areas predominantly see normal deliveries, city corporation areas exhibit a higher prevalence of cesarean section. The study also highlights disparities in delivery methods based on factors such as geographic location, healthcare facility type, education level, and the wealth quintile.
Conclusion
In conclusion, the Bangladesh Sample Vital Statistics 2022 report underscores the diverse landscape of childbirth practices across different regions and socioeconomic strata within the country. The significant prevalence of cesarean sections in urban areas, particularly in private healthcare facilities, suggests potential overutilization of this intervention. Addressing these disparities and ensuring appropriate access to obstetric care aligned with evidence-based practices are crucial for promoting maternal and infant health outcomes in Bangladesh, and future research, capacity building, collaboration with NGS, and other private sectors are crucial for tailored interventions and sustainable solutions.
The Development of Space-Time Interferences in the child’s mind: Memory capacities as the core mechanism of interference
Authors: Hallez Quentin , Balci Fuat 
Published: February 2024

Abstract

This study investigated the development of spatiotemporal perceptual interactions in 5-to-7 years old children. Participants reproduced the temporal and spatial interval between sequentially presented visual stimuli. The time and spacing between stimuli were experimentally manipulated. In addition, cognitive capacities were assessed using neuropsychological tests. Results revealed that starting at 5 years old, children exhibited spatial biases in their time estimations and temporal biases in their spatial estimations, pointing at space-time interference. In line with developmental improvement of temporal and spatial abilities, these spatiotemporal biases decreased with age. Importantly, short-term memory capacity was a predictor of space-time interference pointing to shared cognitive mechanisms between time and space processing. Our results support the symmetrical hypothesis that proposes a common neurocognitive mechanism for processing time and space.
Chimera of fossil biomolecules found in Pleistocene fossil in tropical cave: Fossil biofilm characterization by micro Raman spectroscopy
Authors: de Sousa Daniel Vieira , Maia Paulo Victor Sciammarella , Eltink Estevan , Guimarães Luciano de Moura 
Published: February 2024

Abstract

Finding biomolecules in fossils is a challenging task as they tend to degrade over time due to physical, chemical, and biological factors. The primary hypothesis explaining the presence of biomolecules in fossilized bone suggests that they were preserved during the fossilization process. Some studies posit that these biomolecules may result from contamination by bacteria biofilm formed during fossilization, or they could be artifacts arising from measurement procedures. Several studies on the fossilization process, covering diverse fossil ages and environmental conditions, have used Raman spectroscopy. They report the detection of multiple bands between 1200 to 1800 cm-1 associated with organic compounds, yet a complete understanding of the significance of these bands remains elusive. Our aim is to address this issue through Raman spectroscopy investigations on Pleistocene teeth from Tayassu and Smilodon populator. These fossils were obtained from a well-preserved stratigraphic sequence in Toca de Cima do Pilão cave, near the National Park of Serra da Capivara in semiarid Brazil. We propose two hypotheses to explain the presence of organic compounds in fossil bones: i) these compounds serve as biological signatures related to preserved fossil biomolecules, or ii) they are biological signatures associated with the formation of bacterial biofilm. Our results align with the second hypothesis, showing that these organic signatures are linked to biofilm formation, with a high likelihood of biofilm degradation. However, the specific mechanisms involved in the natural degradation of biofilm in fossil records remain unexplored in this study. In our case, the formation of biofilm on fossil bones is attributed to the oligotrophic conditions of the cave sediment matrix. We present a comprehensive model to elucidate the existence of biofilm on fossil bones, emphasizing the pivotal role of post-depositional processes, especially water action, in the cave environment. As the fossils were discovered in a cave setting, post-depositional processes significantly contribute to the formation of the biofilm matrix. Although our study provides insights into biofilm formation, further research is needed to delve into the specific mechanisms driving natural biofilm degradation in fossil records.
Smartphone addiction may reduce prefrontal cortex activity: an assessment using cerebral blood flow
Authors: Suzuki Takuya , Waki Hideaki , Hisajima Tatsuya 
Published: February 2024

Abstract

Previous studies have reported that increased smartphone use is associated with cognitive function decline. To date, the hemodynamics in the prefrontal cortex (PFC) due to smartphone addiction have not been elucidated. This study aimed to examine the relationship between smartphone addiction and PFC activity. After measuring the smartphone usage time using an application, we evaluated smartphone addiction, depression, and sleep quality using questionnaires. In addition, to assess PFC activity, which is responsible for working memory, we measured cerebral blood flow in the PFC during verbal and spatial working memory tasks (VWM and SWM, respectively). Cerebral blood flow was measured in terms of the oxygenated hemoglobin levels using a 16-channel (Ch) near-infrared spectrometer. Data from 79 participants were analyzed. First, we found that smartphone addiction was positively correlated with depression, but not with the smartphone usage time and sleep quality. Second, after excluding the influence of depression, we found that smartphone addiction was negatively correlated with cerebral blood flow in Ch10 during VWM and in Ch6, 7, and 10 during SWM. These Chs correspond to the frontopolar cortex (FPC), which is part of the PFC, suggesting that smartphone addiction may reduce FPC activity.
Genomic Regions Influencing the Hyperspectral Phenome of Deoxynivalenol Infected Wheat
Authors: Concepcion Jonathan S. , Noble Amanda D. , Thompson Addie M. , Dong Yanhong , Olson Eric L. 
Published: February 2024

Abstract

The quantitative nature of Fusarium Head Blight (FHB) resistance requires further exploration of the wheat genome to identify regions conferring resistance. In this study, we explored the application of hyperspectral imaging of Fusarium-infected wheat kernels and identify regions of the wheat genome contributing significantly to the accumulation of Deoxynivalenol (DON) mycotoxin. Strong correlations were identified between hyperspectral reflectance values for 204 wavebands in the 397 nm to 673 nm range and DON mycotoxin. Dimensionality reduction using principal components was performed for all 204 wavebands and 38 sliding windows across the range of wavebands. PC1 of all 204 wavebands explained 70% of the total variation in waveband reflectance values and was highly correlated with DON mycotoxin. PC1 was used as a phenotype in GWAS and a large effect QTL on chromosome 2D was identified for PC1 of all wavebands as well as nearly all 38 sliding windows. The allele contributing variation in PC1 values also led to a substantial reduction in DON. The 2D polymorphism affecting DON levels localized to the exon of TraesCS2D02G524600 which is upregulated in wheat spike and rachis tissues during FHB infection. This work demonstrates the value of hyperspectral imaging as a correlated trait for investigating the genetic basis of resistance and developing wheat varieties with enhanced resistance to FHB.
FFF print defect characterization through in-situ electrical resistance monitoring
Authors: Jonkers Heime , Dijkshoorn Alexander , Stramigioli Stefano , Krijnen Gijs 
Published: February 2024

Abstract

Fused Filament Fabrication is a popular fabrication technique. Currently there is a need for in-situ monitoring modalities to gather real-time information on prints, both for quality control and closed-loop control. Despite current advancements, effective and affordable in-situ monitoring techniques for non-destructive defect detection of voids and bonding quality are still limited. This work demonstrates in-situ monitoring of Fused Filament Fabrication through electrical resistance measurements as an alternative to thermal and optical methods. A new, easy-to-implement setup is demonstrated which measures the electrical resistance of a conductively doped filament between the nozzle and single or multi-electrodes on the bed. Defects can be located in an unprecedented way with the use of encoded axes in combination with the observed resistance variations throughout the part. A model of the anisotropic electrical conduction is used to interpret the measurements, which matches well with the data. Warping, inter-layer adhesion, under-extrusion and overhang sagging print defects can be observed in the measurements of parts with a complex geometry, which would be difficult to measure otherwise. Altogether in-situ electrical resistance monitoring offers a tool for optimising prints by online studying the influence of the print parameters for quality assessment and it opens up possibilities for closed-loop control.
Determination of Serum Immunoglobulin G Concentration in Lamb and Goat Kid, Awash Fentale, Afar Nations Regional State, Ethiopia
Authors: Desta Negash , Legesse Kibeb , Jackson Wendi , Kebede Nigatu , Smith Watrina 
Published: February 2024

Abstract

In this study, a total of 143 heads (97 lambs and 46 goats) were randomly selected from 3 villages in Awash Fentale district, Afar Regional State, Ethiopia. To determine the serum IgG concentration of lamb and goat kids in the study area and to determine the effect of parity, age, birth type, sex, and dam body condition on the transfer of passive immunoglobulin concentration in the study area. A lamb and goat kid blood sample was taken at 2–7 days of age. 4 ml of blood was collected from a jugular vein puncture in a sterile plain tube, and serum was collected by centrifugation. The species-specific sheep and goat radial immuno diffusion kit-analyzed serum results after 24 hours showed a range of 47.64 to 6071.632 mg/dl serum IgG concentration in lamb and goat kids, ranging from 169.577 to 3559.875 mg/dl serum IgG concentration. The radial immuno diffusion result showed that 21.6% of newborn lambs in the study area had a failure of passive immunoglobulin concentration, 78.4% had adequate passive immunity, 83.4% of goat kids had an adequate passive immunoglobulin concentration, and 16.6% of kids had a failure of passive immunoglobulin concentration from their dams. The result showed that failure of passive immunity was important in the study area. Among the considered risk factors evaluated by simple and multiple logistic regression, the age of the lamb and type of delivery had a statistically significant P value (P < 0.05) on the lamb. Generally, passive immunity transfer is increased by colostrum feeding and animal husbandry management interventions, which is significant for pastoralists whose livelihoods are dependent on livestock.