bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paper-based Microfluidic Devices for the Analysis of Various Pathogens
from Diverse Samples
Authors: Singh Namita Ashish , Rai Nitish , Singh Ashish Kumar , Jain Vidhi , Narang Jagriti 
Published: March 2024

Abstract:
In today’s era, detection of disease is utmost important for the management of disease.
Early detection leads to early management of disease. Paper-based microfluidic devices are promising
technologies that are cost-effective, portable and easy to use over conventional methods. In addition,
paper-based microfluidics offers low reagent/sample volume, less response time and can be
used in resource-limited settings. Researchers are highly fascinated by this technology as it has a lot
of potential to convert into commercial monitoring devices. The present article covers the uses of
paper-based microfluidic technology for the swift and sensitive detection of pathogens from diverse
samples, viz. food, water and blood. In this comprehensive review, paper-based microfluidic devices
are introduced, including the basic concepts, current status and applications, along with the discussion
of the limitations of microfluidics for the detection of pathogens. Although paper-based microfluidic
devices are being developed, their commercialization requires simplification of manufacturing
processes, reduction in production costs as well as an increase in production efficiency. Nonetheless,
the integration of artificial intelligence (AI) and the Internet of Things (IoT) like smartphones, digital
cameras, webcam etc. with paper-associated diagnosis has transformed the point-of-care (POC) diagnostics.
Temporal Trends of Asthma Among Children in the Western Pacific Region From 1990 to 2045: Longitudinal Observational Study
Authors: Yang Cheng-hao , Li Xin-yu , Lv Jia-jie , Hou Meng-jie , Zhang Ru-hong , Guo Hong , Feng Chu 
Published: March 2024

Background
Asthma has become one of the most common chronic conditions worldwide, especially among children. Recent findings show that the prevalence of childhood asthma has increased by 12.6% over the past 30 years, with >262 million people currently affected globally. The reasons for the growing asthma epidemic remain complex and multifactorial.

Objective
This study aims to provide an up-to-date analysis of the changing global and regional asthma prevalence, mortality, disability, and risk factors among children aged <20 years by leveraging the latest data from the Global Burden of Disease Study 2019. Findings from this study can help inform priority areas for intervention to alleviate the rising burden of childhood asthma globally.

Methods
The study used data from the Global Burden of Disease Study 2019, concentrating on children aged 0 to 14 years with asthma. We conducted an in-depth analysis of asthma, including its age-standardized prevalence, incidence, mortality, and disability-adjusted life years (DALYs), across diverse demographics, such as region, age, sex, and sociodemographic index, spanning 1990 to 2019. We also projected the future burden of the disease.

Results
Overall, in the Western Pacific Region, the age-standardized prevalence rate of asthma among children increased slightly, from 3898.4 cases per 100,000 people in 1990 to 3924 per 100,000 in 2019. The age-standardized incidence rate of asthma also increased slightly, from 979.2 to 994.9 per 100,000. In contrast, the age-standardized death rate of asthma decreased from 0.9 to 0.4 per 100,000 and the age-standardized DALY rate decreased from 234.9 to 189.7 per 100,000. At the country level, Japan experienced a considerable decrease in the age-standardized prevalence rate of asthma among children, from 6669.1 per 100,000 in 1990 to 5071.5 per 100,000 in 2019. Regarding DALYs, Japan exhibited a notable reduction, from 300.6 to 207.6 per 100,000. Malaysia also experienced a DALY rate reduction, from 188.4 to 163.3 per 100,000 between 1990 and 2019. We project that the burden of disease in countries other than Japan and the Philippines will remain relatively stable up to 2045.

Conclusions
The study indicates an increase in the prevalence and incidence of pediatric asthma, coupled with a decrease in mortality and DALYs in the Western Pacific Region between 1990 and 2019. These intricate phenomena appear to result from a combination of lifestyle shifts, environmental influences, and barriers to health care access. The findings highlight that nations such as Japan have achieved notable success in managing asthma. Overall, the study identified areas of improvement in view of persistent disease burden, underscoring the need for comprehensive collaborative efforts to mitigate the impact of pediatric asthma throughout the region.
Differences in maternal role attainment in stunting prevention in rural and urban areas of Jember regency
Authors: Ayesie Natasa Zulka  , Dwi Indah Lestari  , Muhammad Zainullah  
Published: March 2024

Introduction: The sociodemographic conditions of Jember Regency can shaped the role attainment of mothers in preventing stunting. The Maternal Role Attainment theory, explains that the mother's role attainment was influenced by 3 factors, namely the macrosystem, mesosystem and microsystem. Objectives: The purpose of this study was to analyze differences in maternal role attainment in rural and urban areas of Jember Regency. Methods: The research design used was descriptive analytical with a cross sectional approach. Total sample of 215 mothers who met the inclusion criteria was selected using the multistage random sampling technique. Data were analyzed using Mann Withney U Test with α = 0.05. Results: there was a difference between the role attainment of mothers in rural and urban areas (0.032<0.05). Conclusions: Based on the theory of maternal role attainment, differences in maternal role attainment in rural and urban areas were influenced by macrosystems, mesosystems, and microsystems as well as components of the mother's self. Further research can analyze the determinant factors in the differences in role attainment.
Farm diversification through agritourism: innovation synergies
Authors: Wu Tsung-Chiung (Emily) , Chen Chiu-Pin , Hsu Alex Yang-chan , Wall Geoffrey 
Published: March 2024

Abstract
Agritourism is considered an effective strategy for revitalizing traditional agriculture, enhancing rural economics, and achieving sustainable livelihoods. While the processes of how the conventional agrarian industry has taken up diversified management and affiliated with the creative supply of tourist services remain unclear, the theoretical interpretations of the diversification processes have yet to be articulated. This study explores agritourism innovation and proposes a conceptual framework of agritourism diversification built upon the connotations of integration of production sectors and the multi-functionality of rural and land resources. Different styles of agritourism innovation detail the progress of agritourism diversification and how various functions of farm resources are initiated and capitalized upon. Results show that diversification through agritourism has brought considerable economic returns to farms, and increased their resilience in the face of possible business challenges.
Health-related quality of life, needs, and concerns among cancer survivors referred to rehabilitation in primary healthcare setting
Authors: Sandager Mette T. , Rossen Sine , Hofland Dorte T. , Nielsen Claus V. , Maribo Thomas 
Published: March 2024

Background and purpose: There is a growing need for rehabilitation services beyond hospitals. This study aims to describe challenges faced by cancer survivors (CSs) referred for rehabilitation in primary healthcare, employing standardized scales measuring health-related quality of life (HRQOL) and open-ended questions. Furthermore, the study explores the applicability of patient-reported outcomes (PROs) in comprehensively understanding challenges encountered by CSs.
Material and methods: This cross-sectional study involves CSs referred for cancer rehabilitation in a primary healthcare setting, including those participating in PROs as a part of routine practice. HRQOL was assessed using the Functional Assessment of Cancer Therapy-General (FACT-G). The International Classification of Functioning, Disability and Health (ICF) framed the analysis of responses to open-ended questions ‘what concerns you the most?’ and ‘what matters to you?’
Results: FACT-G showed the lowest scores for functional well-being (14.4) and emotional well-being (16.6), with higher scores for physical well-being (18.9) and social/family well-being (21.1). Responses to open-ended questions unveiled worries about everyday life and how cancer will impact family well-being presently and in the future. Furthermore, CSs reported a need to maintain normality and proactively address the challenges posed by the disease.
Interpretation: CSs referred for rehabilitation in primary healthcare experience comprehensive challenges necessitating a holistic rehabilitation approach. This includes interventions supporting CSs in dealing with uncertainty, regaining a sense of control, and addressing family well-being concerns. When using PROs for need assessment, the combination of validated HRQOL scales and open-ended questions is crucial for an in-depth understanding of CSs’ challenges.
The Performance of a Solar Panel with Maximum Power Point Tracking (MPPT) System
Authors: Haque Mohammad Asadul , Rashid Mamun Ur 
Published: March 2024

Due to the rotation of the earth and its spherical shape the availability of sunlight at a certain place is not same. At normal sky condition at a place sunlight is minimum at morning that gradually increase upto 2-3 pm then again tends to minimum. Usually, solar panels are fixed type and can’t absorb the sunlight whole day properly. In that sense, to increase the efficiency of a solar panel with its necessary accessories has been developed where maximum power point tracking (MPPT) system adopted. In this system the panel can easily move to get the maximum sunlight. The electric charges are then store in a battery that are being supplied to the electric appliances. The experimental work has been done at the roof-top of science faculty building of Chittagong University. This experimental study shows that the efficiency of the solar panel starts increasing from morning 9 am with efficiency of 16.64% and found maximum with efficiencies at 12 noon (24.92%); 1 pm (25.94%); and at 2 pm (24.68%) then again starts decreasing with the values of (22.3%) & (18.7%) at 3 and 4 pm respectively. Another, It has also been found that the peak value of average efficiency on July is (24.44%). The achieved efficiencies are more than the efficiency of (15.7%) studied on May-2017 with a fixed-type solar panel at the same place [M. A. Haque et al. 2018].
Impact of Cardiorenal Anaemia Syndrome on Clinical Features in Elderly Outpatients with Chronic Heart Failure: A Japanese Community Hospital Experience
Authors: Ito Shigenori , Kato Shinji 
Published: March 2024

Background: Cardiorenal anaemia syndrome (CRAS) has been reported to be associated with all-cause mortality and cardiovascular events in outpatients with heart failure (HF).
Objective: To evaluate the clinical situation of CRAS including NYHA class and care status in elderly outpatients with HF.
Methods: A total of 41 elderly (>65 years) outpatients with HF attending our hospital were analysed retrospectively and cross-sectionally. Clinical variables included lifestyle diseases, atrial fibrillation, valvular heart disease, HFpEF, chronic kidney disease (CKD), cardiac function (LVEF, E/e’, LADI, BNP), anaemia (Hb, Fe/TIBC (%), ferritin), medications (diuretics, MRA, ACEI/ARB, β-blockers, SGLT2i, ARNI, tolvaptan), NYHA class (I/II/III/IV). The nursing variables analysed were Japanese nursing certification class, which assesses active daily living (ADL), instrumental ADL, cognitive function, mental function, physical function, communication, and need for support/care (from least to most intensive, independence 0/support(S)1/S2/care(C)1/C2/C3/C4/C5) and frailty. Subjects were divided into two groups (CRAS+group and CRAS−group) according to the presence of CRAS, defined as HF associated with CKD (eGFR < 60 mL/min/1.73 m2) and anaemia (Hb < 13 g/dL, men and Hb < 12 g/dL, women). All variables were compared between the two groups.
Results: Mean age was 83.7 ± 7.1 years (67∼100). Female gender was 63.4% (26/41). The incidence of HFpEF was 33/41 (80.5%). The incidence of CRAS was 53.7% (22/41). The incidence of lifestyle diseases was not different between the two groups. Cardiac function was not significantly different between the two groups (CRAS+ vs. CRAS−): LVEF (59.1 ± 8.3 vs. 61.3 ± 7.2); E/e (15.1 ± 5.8 vs. 15.0 ± 7.0); LAVI (50.6 ± 16.6 vs. 54.3 ± 30.9); BNP (347.0 ± 234.4 vs. 291.3 ± 197.0). Hb was significantly lower in the CRAS+ group than in the CRAS group (10.4 ± 1.4 vs. 13.4 ± 1.7, P < 0.0001). Fe/TIBC and ferritin were not significantly different between the two groups. Regarding medications, tolvaptan tended to be used more frequently in the CRAS+ group than in the CRSA− group (4/22 vs. 0/18, P = 0.111). The other drugs were used with similar frequency. Meanwhile, the NYHA class tended to be higher in the CRAS+ group than in the CRAS− group: NYHA (8/9/5/0 vs. 8/11/0/0, P = 0.082). Nursing class showed more intensive care in the CRAS+ group than in the CRAS−group (4/3/3/2/4/1/3/2 vs. 11/0/6/1/0/1/0/0, P = 0.021).
Conclusions: The association of CRAS with HF was associated with more intensive support/care status but not with cardiac function/BNP and other factors. Prevention and active treatment of CRAS may improve the independence of elderly outpatients with HF.
AGE CHARACTERISTICS OF CHANGES IN THE LYMPHOID POPULATION STRUCTURE OF THE RATS’ THYMUS AFTER ACUTE DISTURBANCE OF CEREBRAL BLOOD FLOW IN THE BASIN OF CAROTID ARTERIES
Authors: Tkachuk Svitlana , Tkachuk Oleksii , Denysenko Olga 
Published: March 2024

Abstract. Today, the most common causes of disability and mortality on the planet include acute disorders of cerebral blood circulation, the spectrum of which is dominated by ischemic lesions. Advances in neuroimmunology and neuroimmunopathology have made it possible to attribute cerebral blood circulation disorders to immune- dependent diseases of the nervous system, therefore, the emphasis in the search of new approaches to the eﬀ ectiveness increase of stroke therapy has shifted from the correction of local changes in the brain itself to the reaction of the immune system organs, as a possible target of pharmacological eﬀ ects, that will make it possible to reduce the secondary death of neurons as a result of inﬂ ammation.The purpose of the work. to investigate the age-speciﬁ c changes in the structure of the lymphoid population of the thymus after acute disruption of cerebral blood ﬂ ow in the basin of the carotid arteries in six- and ninemonth-old rats.Material and methods. Acute cerebrovascular accident was simulated in 6- and 9-month-old white nonlinear laboratory rats by bilateral carotid artery clamping for 20 min. followed by reperfusion. The thymus was taken on the 12th day of the postischemic period, it was ﬁ xed in Buen’s solution, after standard histological processing, serial sections with a thickness of 5 μm were made, stained with hematoxylin- eosin. In the subcapsular, deep cortical zones, intralobular perivascular spaces and the medullary zone of the thymus, the structure of the lymphoid population (density of diﬀ erent classes of thymocytes per 1 mm2) was studied in the digital image analysis system VIDAS-386 (Kontron Electronik, Germany) with a ﬂ uorescent microscope AXIOSKOP (Zeiss, Germany) in automatic mode.The results. In the structure of the lymphoid population of all structural and functional zones of the thymus, small lymphocytes predominate. Age-related diﬀ erences in the structure of the lymphoid population of the thymus of the control groups consist of lower indicators of the density of medium and small thymocytes in all investigated zones of the gland of animals of the older age group, with the exception of the subcapsular, in which the density of small thymocytes is higher in nine-month-old rats. On the 12th day after simulation of ischemia- reperfusion of the brain injury the number of destructive thymocytes and thymocytes with the signs of apoptosis increases in the subcapsular and deep cortical zones of the thymus of six-month-old rats, but in nine-month-old rats in all zones of the gland, except the brain, the density of destructive and apoptotic cells decreases.Conclusions. Ischemic- reperfusion injury of the brain modiﬁ es the structure of the lymphoid population of the thymus of rats, and the nature of these modiﬁ cations is determined by age and structural and functional zones of the gland.
Equine gamma herpesvirus presence and viral load are not associated with equine glandular gastric disease
Authors: Thompson Rachelle N. , Pearson Erin , McDonough Sean P. , Iannitti Helenrose , Van de Walle Gerlinde R. , Banse Heidi , Perkins Gillian A. , Tomlinson Joy E. 
Published: March 2024

Abstract

OBJECTIVE
To investigate the role of equine herpesvirus-2 (EHV-2) and equine herpesvirus-5 (EHV-5) in equine glandular gastric disease (EGGD) by visualizing and quantifying these gamma herpesviruses in EGGD-affected and normal glandular gastric mucosa of horses. A secondary objective was to describe the histopathological abnormalities in the equine gastric glandular mucosa in horses with EGGD.

ANIMALS
29 horses (n = 21 postmortem and 8 gastroscopy) categorized as normal (11), EGGD (12), or both EGGD and equine squamous gastric disease (6).

METHODS
Glandular gastric mucosal samples were collected from horses by gastroscopy or postmortem. Histopathology and in situ hybridization targeting EHV-2 and EHV-5 were performed on grossly normal and abnormal glandular gastric mucosa. The number of in situ hybridization-positive cells per millimeter squared of tissue was calculated. Evaluators were blinded to groups.

RESULTS
Glandular gastric tissues from horses without EGGD had higher viral loads in the mucosa than normal or abnormal tissues from EGGD horses. There was no difference in viral loads for EHV-2 or EHV-5 between grossly or endoscopically normal to abnormal gastric tissues within horses with EGGD. Lymphocytic plasmacytic gastritis was the most common histopathological abnormality, with only 3 horses having mucosal disruption (glandular ulcer or erosion).

CLINICAL RELEVANCE
Equine gamma herpesviruses are unlikely to play a role in the pathophysiology of EGGD. EGGD is frequently inflammatory with occasional mucosal disruption (ulcer or erosion).
Mobile Application for Understanding Nutritional Labeling Focused on The Consumer
Authors: Gómez-Mohedano Gisela Yamin , Escorza-Sánchez Yolanda Marysol , Mendoza-Espinoza Héctor Eduardo 
Published: March 2024

Objective: In this multidisciplinary study, a mobile application was designed as a technological tool that contributes to the training of informed consumers capable of interpreting the nutritional characteristics of the products they purchase.

Theoretical Framework: Mobile applications that allow to display the sodium, sugar and fat content of a product in a way that is understandable to the consumer. Additionally, an area of opportunity is evident in the way of presenting this information and in the calculation of daily energy content.

Design/Methodology/Approach: The agile Scrum methodology was used. The requirements of the mobile application were obtained through user stories, which allowed two sprints to be done. The application was subjected to unit and integration testing, connectivity and functionality type.

Findings: Mobile application for users of the Android operating system that allows you to read, through a smartphone, the barcode of a product on the front labeling and display the sugar, sodium and fat content; Moreover, it issues recommendations for their consumption in accordance with the FAO, WHO, UNU.

Research, Practical & Social Implications: Contributes to the training of informed consumers capable of having a better interpretation of the nutritional characteristics of the products they purchase.

Originality/Value: Mobile application that to scan the barcode of a product and graphically display, through teaspoons, the content in grams of sodium, sugar and calories it contains. Moreover, it calculates the daily energy content according to some variables: sex, age, weight and level of physical activity.
Confirmatory Factor Analysis Applied to The Business Model of The Artisan Sector, Case of Tenango de Doria, Hidalgo, Mexico
Authors: Cordero Gabriela Ortiz , Mohedano Gisela Yamin Gómez , Alonso Maria Teresa Sarabia 
Published: March 2024

Purpose: The purpose of this study is to examine the applicability and effectiveness of the Canvas Model in the artisan sector, specifically focusing on microenterprises in Tenango de Doria, Hidalgo, Mexico. The goal is to understand how the various components of the Canvas Model influence the success of local handicrafts, identifying key factors for their development and sustainability.

Theoretical Framework: The study is based on the theoretical foundations of the Canvas Model, which includes nine key elements crucial for business success. Recent literature highlights the need for tailored business strategies in artisan sectors, recognizing the unique challenges and opportunities they present.

Design/Methodology/Approach: A cross-sectional and correlational quantitative research design is adopted. Surveys are conducted with 401 potential customers of "Tenango" handicrafts, followed by a confirmatory factor analysis to evaluate the nine key elements of the Canvas Model.

Findings: The findings underscore the importance of 'sales', 'distribution channels', and 'innovation' in the Canvas Model within the artisan sector, while 'key partners' emerge as less significant. These findings suggest the need to adapt the Canvas Model to the artisanal context, focusing on effective sales and distribution strategies and strengthening the unique value proposition of the crafts.

Research, Practical & Social Implications: This pioneering study provides a solid foundation for future research in the artisan sector and offers valuable insights for the development of business strategies. The findings have significant implications not only for the artisans of Tenango de Doria but also for other artisan contexts, potentially guiding the development and sustainability of micro-enterprises in various cultures and regions.

Originality/Value: The study marks a novel approach by applying a quantitative analysis to assess the Canvas Model in the artisan sector, highlighting the complexities of formulating a successful business model in this field and contributing valuable perceptions for its development and sustainability.