bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benchmarking online food delivery applications against menu labelling laws: a cross-sectional observational analysis
Authors: Cassano Sophia , Jia Anna , Gibson Alice A , Partridge Stephanie R , Chan Virginia , Farrell Penny , Phongsavan Philayrath , Allman-Farinelli Margaret , Jia Si Si 
Published: April 2024

Abstract

Objective:
It is unknown how well menu labelling schemes that enforce the display of kilojoule (kJ) labelling at point-of-sale have been implemented on online food delivery (OFD) services in Australia. This study aimed to examine the prevalence of kJ labelling on the online menus of large food outlets with more than twenty locations in the state or fifty locations nationally. A secondary aim was to evaluate the nutritional quality of menu items on OFD from mid-sized outlets that have fewer locations than what is specified in the current scheme.

Design:
Cross-sectional analysis. Prevalence of kJ labelling by large food outlets on OFD from August to September 2022 was examined. Proportion of discretionary (‘junk food’) items on menus from mid-sized outlets was assessed.

Setting:
Forty-three unique large food outlets on company (e.g. MyMacca’s) and third party OFD (Uber Eats, Menulog, Deliveroo) within Sydney, Australia. Ninety-two mid-sized food outlets were analysed.

Participants:
N/A.

Results:
On company OFD apps, 35 % (7/23) had complete kJ labelling for each menu item. In comparison, only 4·8 % (2/42), 5·3 % (2/38) and 3·6 % (1/28) of large outlets on Uber Eats, Menulog and Deliveroo had complete kJ labelling at all locations, respectively. Over three-quarters, 76·3 % (345/452) of menu items from mid-sized outlets were classified as discretionary.

Conclusions:
Kilojoule labelling was absent or incomplete on a high proportion of online menus. Mid-sized outlets have abundant discretionary choices and yet escape criteria for mandatory menu labelling laws. Our findings show the need to further monitor the implementation of nutrition policies on OFD.
Agendas of Reform: Continuity and Change in Australia’s National Disability Insurance Scheme (NDIS)
Authors: Hummell Eloise , Borg Samantha J. , Foster Michele , Burns Kylie , Harris Rimmer Susan 
Published: April 2024

This article used text mining processes to map continuity and change in policy principles of the National Disability Insurance Scheme (NDIS) in Australia and reflect on the underlying agendas of reform. Specifically, this research aimed to: (1) examine the substantive content of the NDIS legislative, operational and reform documentation, (2) assess changes in objects, principles and issues over time, and (3) discuss the implications of these shifting logics and agendas. To achieve this, text mining approaches were applied to ten key NDIS documents from 2011 to 2019.
The findings included a low prevalence of ‘rights’-based terminology, sustained attention to Scheme ‘costs’ but limited latterly attention to ‘sustainability’, and increasing prominence of interpersonal (e.g., ‘family’, ‘community’) and decision-making terminology (e.g., ‘decision’, ‘review’). How these shifts have influenced subsequent proposed reforms is explored and ongoing dilemmas about designing policy that ensures rights and entitlements, while balancing cost, sustainability and consistency are identified.
Three Trajectories in Nineteenth-Century Anglican Biblical Interpretation: From Narrow to Broad
Authors: Hartin Cole William 
Published: April 2024

Abstract
Contemporary studies of Anglican biblical interpretation in the nineteenth century are scant. Those that do exist tend to paint the biblical interpretation of the period as unidimensional and flat. This paper highlights diverse ways the Bible was interpreted by Anglicans in the nineteenth century by looking at the writings of Charles Simeon, Benjamin Jowett, and Christina Rossetti. Each has interesting and distinct ways of approaching the Bible. The paper analyzes their interpretive practices before tracing them to the present and drawing out significant historical themes in each.
Continued Convergence After the Occurrence of a Slab Break‐Off: The Case of the Cyprian Arc
Authors: Granot R. , Hamiel Y. , Kanari M. , Kurant S. , Katz O. 
Published: April 2024

AbstractThe detachment (i.e., break‐off) of down‐going subducting oceanic slabs is a major geodynamic event with far‐reaching consequences, one of which is the reduction of the slab pull force acting on the trailing plate. We investigate the motion of the Sinai Microplate where a recent (∼1 Myr ago) slab break‐off occurred along its sole converging plate boundary (Cyprian Arc) with the overriding Anatolia Microplate. Based on new bathymetric mapping, high‐resolution seismic reflection imaging, geodetic and earthquake data, we show that Sinai is actively moving in a northwest direction with respect to Nubia. Our results indicate that despite the recent slab break‐off, Sinai has and is still being pulled (or pushed) toward the overriding Anatolia Microplate. The continued convergence possibly occurs because of a persistent slab pull force, a suction force induced by the down‐going detached slab and/or by the upper mantle flow induced by the Afar Plume.
Exploring the Potential of Long Short‐Term Memory Networks for Predicting Net CO2 Exchange Across Various Ecosystems With Multi‐Source Data
Authors: Huang Chengcheng , He Wei , Liu Jinxiu , Nguyen Ngoc Tu , Yang Hua , Lv Yiming , Chen Hui , Zhao Mengyao 
Published: April 2024

AbstractUpscaling flux tower measurements based on machine learning (ML) algorithms is an essential approach for large‐scale net ecosystem CO2 exchange (NEE) estimation, but existing ML upscaling methods face some challenges, particularly in capturing NEE interannual variations (IAVs) that may relate to lagged effects. With the capacity to characterize temporal memory effects, the Long Short‐Term Memory (LSTM) networks are expected to help solve this problem. Here we explored the potential of LSTM for predicting NEE across various ecosystems using flux tower data over 82 sites in North America. The LSTM model with differentiated plant function types (PFTs) demonstrates the capability to explain 79.19% (R2 = 0.79) of the monthly variations in NEE within the testing set, with RMSE and Mean Absolute Error values of 0.89 and 0.57 g C m−2 d−1 respectively (r = 0.89, p < 0.001). Moreover, the LSTM model performed robustly in predicting cross‐site variability, with 67.19% of the sites that can be predicted by both LSTM models with and without distinguished PFTs showing improved predictive ability. Most importantly, the IAV of predicted NEE highly correlated with that in flux observations (r = 0.81, p < 0.001), clearly outperforming that by the random forest model (r = −0.21, p = 0.011). Among all nine PFTs, solar‐induced chlorophyll fluorescence, downward shortwave radiation, and leaf area index are the most important variables for explaining NEE variations, collectively accounting for approximately 54.01% in total. This study highlights the great potential of LSTM for improving carbon flux upscaling with multi‐source remote sensing data.
Surface Resistance Controls Differences in Evapotranspiration Between Croplands and Prairies in U.S. Corn Belt Sites
Authors: Schreiner‐McGraw Adam P. , Baker John M. , Wood Jeffrey D. , Abraha Michael , Chen Jiquan , Griffis Timothy J. , Robertson G. Phillip 
Published: April 2024

AbstractWater returned to the atmosphere as evapotranspiration (ET) is approximately 1.6x global river discharge and has wide‐reaching impacts on groundwater and streamflow. In the U.S. Midwest, widespread land conversion from prairie to pasture to cropland has altered spatiotemporal patterns of ET, yet there is not consensus on the direction of change or the mechanisms controlling changes. We measured ET at three locations within the Long‐Term Agroecosystem Research network along a latitudinal gradient with paired rainfed cropland and prairie sites at each location. At the northern locations, the Upper Mississippi River Basin (UMRB) and Kellogg Biological Station (KBS), the cropland has annual ET that is 84 and 29 mm/year (22% and 5%) higher, respectively, caused primarily by higher ET during springtime when fields are fallow. At the southern location, the Central Mississippi River Basin (CMRB), the prairie has 69 mm/year (11%) higher ET, primarily due to a longer growing season. Differences in climate and that the CMRB prairie is remnant native prairie, while the UMRB and KBS prairies are restored, make it challenging to attribute differences to specific mechanisms. To accomplish this, we examine the energy balance using the Two‐Resistance Method (TRM). Results from the TRM demonstrate that higher surface conductance in croplands is the primary factor leading to higher springtime ET from croplands, relative to prairies. Results from this study provide insight into impacts of warm season grasses on the hydrology of the U.S. Corn Belt by providing a mechanistic understanding of how land use change affects the water budget.
TRIB3 promotes the progression of renal cell carcinoma by upregulating the lipid droplet-associated protein PLIN2
Authors: Li Jun , Zhang Qian , Guan Yupeng , Liao Dingzhun , Chen Huikun , Xiong Haiyun , Sheng Yiyu , Chen Xianju , Pang Jun 
Published: April 2024

AbstractAbnormal lipid metabolism and lipid accumulation are characteristic hallmarks of renal cell carcinoma (RCC). While there is prior evidence closely linking such lipid accumulation within RCC cells and consequent tumorigenesis, the mechanisms underlying this process remain incompletely understood. In this study, a series of bioinformatics analyses were initially performed by screening RCC databases and gene sets, ultimately leading to the identification of TRIB3 as an oncogene that functions as a central regulator of lipid metabolism. TRIB3 overexpression was observed in both RCC patient tumor tissues and cell lines, and this upregulation was correlated with a worse RCC patient prognosis. When TRIB3 was knocked down, this resulted in a reduction in lipid accumulation and the consequent induction of endoplasmic reticulum (ER) stress-related apoptotic cell death. At the molecular level, interactions between TRIB3 and PLIN2 were found to abrogate TEB4-mediated PLIN2 ubiquitination and consequent degradation, thus maintaining higher PLIN2 expression levels. This simultaneously helps facilitate the accumulation of lipids while preserving ER homeostasis, thus driving accelerated RCC tumor progression. This TRIB3-PLIN2 axis thus represents a promising new target for efforts to treat RCC.
Atomic reconstruction for realizing stable solar-driven reversible hydrogen storage of magnesium hydride
Authors: Zhang Xiaoyue , Ju Shunlong , Li Chaoqun , Hao Jiazheng , Sun Yahui , Hu Xuechun , Chen Wei , Chen Jie , He Lunhua , Xia Guanglin , Fang Fang , Sun Dalin , Yu Xuebin 
Published: April 2024

AbstractReversible solid-state hydrogen storage of magnesium hydride, traditionally driven by external heating, is constrained by massive energy input and low systematic energy density. Herein, a single phase of Mg2Ni(Cu) alloy is designed via atomic reconstruction to achieve the ideal integration of photothermal and catalytic effects for stable solar-driven hydrogen storage of MgH2. With the intra/inter-band transitions of Mg2Ni(Cu) and its hydrogenated state, over 85% absorption in the entire spectrum is achieved, resulting in the temperature up to 261.8 °C under 2.6 W cm−2. Moreover, the hydrogen storage reaction of Mg2Ni(Cu) is thermodynamically and kinetically favored, and the imbalanced distribution of the light-induced hot electrons within CuNi and Mg2Ni(Cu) facilitates the weakening of Mg-H bonds of MgH2, enhancing the “hydrogen pump” effect of Mg2Ni(Cu)/Mg2Ni(Cu)H4. The reversible generation of Mg2Ni(Cu) upon repeated dehydrogenation process enables the continuous integration of photothermal and catalytic roles stably, ensuring the direct action of localized heat on the catalytic sites without any heat loss, thereby achieving a 6.1 wt.% H2 reversible capacity with 95% retention under 3.5 W cm−2.
Full integration of highly stretchable inorganic transistors and circuits within molecular-tailored elastic substrates on a large scale
Authors: Kang Seung-Han , Jo Jeong-Wan , Lee Jong Min , Moon Sanghee , Shin Seung Bum , Choi Su Bin , Byeon Donghwan , Kim Jaehyun , Kim Myung-Gil , Kim Yong-Hoon , Kim Jong-Woong , Park Sung Kyu 
Published: April 2024

AbstractThe emergence of high-form-factor electronics has led to a demand for high-density integration of inorganic thin-film devices and circuits with full stretchability. However, the intrinsic stiffness and brittleness of inorganic materials have impeded their utilization in free-form electronics. Here, we demonstrate highly integrated strain-insensitive stretchable metal-oxide transistors and circuitry (442 transistors/cm2) via a photolithography-based bottom-up approach, where transistors with fluidic liquid metal interconnection are embedded in large-area molecular-tailored heterogeneous elastic substrates (5 × 5 cm2). Amorphous indium-gallium-zinc-oxide transistor arrays (7 × 7), various logic gates, and ring-oscillator circuits exhibited strain-resilient properties with performance variation less than 20% when stretched up to 50% and 30% strain (10,000 cycles) for unit transistor and circuits, respectively. The transistors operate with an average mobility of 12.7 ( ± 1.7) cm2 V−1s−1, on/off current ratio of > 107, and the inverter, NAND, NOR circuits operate quite logically. Moreover, a ring oscillator comprising 14 cross-wired transistors validated the cascading of the multiple stages and device uniformity, indicating an oscillation frequency of ~70 kHz.
Decreased Indian Ocean Dipole variability under prolonged greenhouse warming
Authors: Kim Soong-Ki , Park Hyo-Jin , An Soon-Il , Liu Chao , Cai Wenju , Santoso Agus , Kug Jong-Seong 
Published: April 2024

AbstractThe Indian Ocean Dipole (IOD) is a major climate variability mode that substantially influences weather extremes and climate patterns worldwide. However, the response of IOD variability to anthropogenic global warming remains highly uncertain. The latest IPCC Sixth Assessment Report concluded that human influences on IOD variability are not robustly detected in observations and twenty-first century climate-model projections. Here, using millennial-length climate simulations, we disentangle forced response and internal variability in IOD change and show that greenhouse warming robustly suppresses IOD variability. On a century time scale, internal variability overwhelms the forced change in IOD, leading to a widespread response in IOD variability. This masking effect is mainly caused by a remote influence of the El Niño–Southern Oscillation. However, on a millennial time scale, nearly all climate models show a long-term weakening trend in IOD variability by greenhouse warming. Our results provide compelling evidence for a human influence on the IOD.
Comparison of efficacy and safety of equivalent doses of remimazolam versus propofol for gastroscopy anesthesia in elderly patients
Authors: Chen Di , Liao Min , Wu Xiao-ru , Zhao Tang-yuan-meng , Sun Hu 
Published: April 2024

AbstractRemimazolam, a novel intravenous anesthetic, has been proven to be safe and efficacious in the gastroscopy setting among the elderly. However, reports comparing the effectiveness and safety of using equivalent doses of remimazolam with propofol have not been seen. The aim of this study was to compare the sedation efficacy and safety of the 95% effective doses (ED95) of remimazolam versus propofol combined with sufentanil in the gastroscopy setting among the elderly. In the first step of this two-step study, a modified up-and-down method was used to calculate the ED95 of remimazolam and propofol when combined with 0.1 µg/kg sufentanil in inhibiting body movement of elderly patients undergoing gastroscopy. In the second step, ED95 of both agents calculated in the first step were administered, endpoints of efficacy, safety, and incidence of adverse events were compared. A total of 46 individuals completed the first step. The ED95 of remimazolam was 0.163 mg/kg (95% CI 0.160–0.170 mg/kg), and that of propofol was 1.042 mg/kg (95% CI 1.007–1.112 mg/kg). In the second step, 240 patients completed the trial. The anesthetic effective rates of the remimazolam group and the propofol group were 78% and 83%, respectively, with no statistical difference (P = 0.312). Patients in the remimazolam group had more stable circulatory functions (P < 0.0001) and a lower incidence of pain on injection (3.3% vs. 19.5%, P < 0.0001). The incidence of hypotension was low in the remimazolam versus propofol group (15.6% vs. 39.0%, P < 0.0001). Overall adverse event was low in the remimazolam versus propofol group (21.3% vs. 62.7%, P < 0.0001).In this study, we found that when anesthesia was administered to elderly gastroscopy patients based on 95% effective doses of remimazolam and propofol, remimazolam was as effective as propofol, but was safer with a lower incidence of adverse events.Study registration: Chinese Clinical Trial Registry, ChiCTR2000034234. Registered 29/06/2020, https://www.chictr.org.cn.
Exploring bi-carbazole-linked triazoles as inhibitors of prolyl endo peptidase via integrated in vitro and in silico study
Authors: Ullah Saeed , Mansoor Farheen , Khan Salman Ali , Jabeen Uzma , Almars Amany I. , Almohaimeed Hailah M. , Basri Ahmed M. , Alshabrmi Fahad M. 
Published: April 2024

AbstractA serine protease called prolyl endopeptidase (PEP) hydrolyses the peptide bonds on the carboxy side of the proline ring. The excessive PEP expression in brain results in neurodegenerative illnesses like dementia, Alzheimer’s disease, and Parkinson's disease. Results of the prior studies on antioxidant activity, and the non-cytotoxic effect of bi-carbazole-linked triazoles, encouraged us to extend our studies towards its anti-diabetic potential. Hence, for this purpose all compounds 1–9 were evaluated to reveal their anti-prolyl endo peptidase activity. Fortunately, seven compounds resulted into significant inhibitory capability ranging from 26 to 63 µM. Among them six compounds 4–9 exhibited more potent inhibitory activity with IC50 values 46.10 ± 1.16, 42.30 ± 1.18, 37.14 ± 1.21, 26.29 ± 0.76, 28.31 ± 0.64 and 31.11 ± 0.84 µM respectively, while compound 3 was the least active compound in the series with IC50 value 63.10 ± 1.58 µM comparing with standard PEP inhibitor bacitracin (IC50 = 125 ± 1.50 µM). Moreover, mechanistic study was performed for the most active compounds 7 and 8 with Ki values 24.10 ± 0.0076 and 23.67 ± 0.0084 µM respectively. Further, the in silico studies suggested that the compounds exhibited potential interactions and significant molecular conformations, thereby elucidating the structural basis for their inhibitory effects.
Associations of dietary patterns with brain health from behavioral, neuroimaging, biochemical and genetic analyses
Authors: Zhang Ruohan , Zhang Bei , Shen Chun , Sahakian Barbara J. , Li Zeyu , Zhang Wei , Zhao Yujie , Li Yuzhu , Feng Jianfeng , Cheng Wei 
Published: April 2024

AbstractFood preferences significantly influence dietary choices, yet understanding natural dietary patterns in populations remains limited. Here we identifiy four dietary subtypes by applying data-driven approaches to food-liking data from 181,990 UK Biobank participants: ‘starch-free or reduced-starch’ (subtype 1), ‘vegetarian’ (subtype 2), ‘high protein and low fiber’ (subtype 3) and ‘balanced’ (subtype 4). These subtypes varied in diverse brain health domains. The individuals with a balanced diet demonstrated better mental health and superior cognitive functions relative to other three subtypes. Compared with subtype 4, subtype 3 displayed lower gray matter volumes in regions such as the postcentral gyrus, while subtype 2 showed higher volumes in thalamus and precuneus. Genome-wide association analyses identified 16 genes different between subtype 3 and subtype 4, enriched in biological processes related to mental health and cognition. These findings provide new insights into naturally developed dietary patterns, highlighting the importance of a balanced diet for brain health.
Whole-brain dynamics across the menstrual cycle: the role of hormonal fluctuations and age in healthy women
Authors: Avila-Varela Daniela S. , Hidalgo-Lopez Esmeralda , Dagnino Paulina Clara , Acero-Pousa Irene , del Agua Elvira , Deco Gustavo , Pletzer Belinda , Escrichs Anira 
Published: April 2024

AbstractRecent neuroimaging research suggests that female sex hormone fluctuations modulate brain activity. Nevertheless, how brain network dynamics change across the female menstrual cycle remains largely unknown. Here, we investigated the dynamical complexity underlying three menstrual cycle phases (i.e., early follicular, pre-ovulatory, and mid-luteal) in 60 healthy naturally-cycling women scanned using resting-state fMRI. Our results revealed that the pre-ovulatory phase exhibited the highest dynamical complexity (variability over time) across the whole-brain functional network compared to the early follicular and mid-luteal phases, while the early follicular showed the lowest. Furthermore, we found that large-scale resting-state networks reconfigure along menstrual cycle phases. Multilevel mixed-effects models revealed age-related changes in the whole-brain, control, and dorsal attention networks, while estradiol and progesterone influenced the whole-brain, DMN, limbic, dorsal attention, somatomotor, and subcortical networks. Overall, these findings evidence that age and ovarian hormones modulate brain network dynamics along the menstrual cycle.
Nondestructive, longitudinal, 3D oxygen imaging of cells in a multi-well plate using pulse electron paramagnetic resonance imaging
Authors: Hameed Safa , Viswakarma Navin , Babakhanova Greta , Simon Carl G. , Epel Boris , Kotecha Mrignayani 
Published: April 2024

AbstractThe use of oxygen by cells is an essential aspect of cell metabolism and a reliable indicator of viable and functional cells. Here, we report partial pressure oxygen (pO2) mapping of live cells as a reliable indicator of viable and metabolically active cells. For pO2 imaging, we utilized trityl OX071-based pulse electron paramagnetic resonance oxygen imaging (EPROI), in combination with a 25 mT EPROI instrument, JIVA-25™, that provides 3D oxygen maps with high spatial, temporal, and pO2 resolution. To perform oxygen imaging in an environment-controlled apparatus, we developed a novel multi-well-plate incubator-resonator (MWIR) system that could accommodate 3 strips from a 96-well strip-well plate and image the middle 12 wells noninvasively and simultaneously. The MWIR system was able to keep a controlled environment (temperature at 37 °C, relative humidity between 70%–100%, and a controlled gas flow) during oxygen imaging and could keep cells alive for up to 24 h of measurement, providing a rare previously unseen longitudinal perspective of 3D cell metabolic activities. The robustness of MWIR was tested using an adherent cell line (HEK-293 cells), a nonadherent cell line (Jurkat cells), a cell-biomaterial construct (Jurkat cells seeded in a hydrogel), and a negative control (dead HEK-293 cells). For the first time, we demonstrated that oxygen concentration in a multi-well plate seeded with live cells reduces exponentially with the increase in cell seeding density, even if the cells are exposed to incubator-like gas conditions. For the first time, we demonstrate that 3D, longitudinal oxygen imaging can be used to assess cells seeded in a hydrogel. These results demonstrate that MWIR-based EPROI is a versatile and robust method that can be utilized to observe the cell metabolic activity nondestructively, longitudinally, and in 3D. This approach may be useful for characterizing cell therapies, tissue-engineered medical products, and other advanced therapeutics.