bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of histone deacetylase inhibitor trichostatin A (TSA) on the incorporation of 32P (Pi) and 3H‐palmitic acid into the phospholipids of Tetrahymena
Authors: Kovács Péter , Csaba György 
Published: December 2006

AbstractHistone deacetylases (HDACs) are able to control also the acetylation of tubulin. In the present experiments the effect of trichostatin A (TSA), a HDAC inhibitor was studied on the incorporation of 3H‐palmitic acid and 32P to the phospholipids (PI, PIP, PS, PC, PA, PE) of Tetrahymena pyriformis, considering earlier observations on the microtubular system's influence on signalling in this unicellular eukaryote. Treatment with 1, 5, or 10 µM TSA was studied. The incorporation of hydrophobic tail component, palmitic acid was inhibited in a concentration dependent manner into all the phospholipids, except for PA, where the incorporation was increased. 32P incorporation was also inhibited. The possible relation between the microtubular system and signalling is discussed. Copyright © 2006 John Wiley & Sons, Ltd.
Cellular Inhibition of Protein Tyrosine Phosphatase 1B by Uncharged Thioxothiazolidinone Derivatives
Authors: Stuible Matthew , Zhao Liang , Aubry Isabelle , Schmidt‐Arras Dirk , Böhmer Frank‐D. , Li Chao‐Jun , Tremblay Michel L. 
Published: December 2006

AbstractAs important regulators of cellular signal transduction, members of the protein tyrosine phosphatase (PTP) family are considered to be promising drug targets. However, to date, the most effective in vitro PTP inhibitors have tended to be highly charged, thus limiting cellular permeability. Here, we have identified an uncharged thioxothiazolidinone derivative (compound 1), as a competitive inhibitor of a subset of PTPs. Compound 1 effectively inhibited protein tyrosine phosphatase 1B (PTP1B) in two cell‐based systems: it sensitized wild‐type, but not PTP1B‐null fibroblasts to insulin stimulation and prevented PTP1B‐dependent dephosphorylation of the FLT3‐ITD receptor tyrosine kinase. We have also tested a series of derivatives in vitro against PTP1B and proposed a model of the PTP1B–inhibitor interaction. These compounds should be useful in the elucidation of cellular PTP function and could represent a starting point for development of therapeutic PTP inhibitors.
Repeat right transradial percutaneous coronary intervention in a patient with dextrocardia: The right approach to the right‐sided heart
Authors: Chen Jack P. 
Published: December 2006

AbstractDextrocardia (DC) is a rare cardiac condition in which the cardiac location, as well as apex, is rightwardly displaced. As the incidence of atherosclerotic disease is similar to that of the general population, there have been few reports of percutaneous coronary interventions (PCIs) in these patients. Proposed technical strategies for successful angiography and PCI in DC include counter‐directional torquing of the catheter, as well as right‐left mirror‐image inversion angiographic views. All previous reports of DC PCIs have been via transfemoral access.We present a case of successful repeat transradial PCI in a patient with DC. This is first report of transradial coronary angiography, PCI, or repeat PCI in a DC patient. A literature review of technical considerations, including our own recommendations for guide catheter selection, are discussed. We also review the anatomic variations and epidemiology of DC. Although access complications for transradial PCI is known to be lower than that of the transfemoral approach, challenges in technique and concern of repeat access have limited the popularity of the former. Our report demonstrates the safety and feasibility of transradial angiography, PCI, and even repeat PCI, in the rare patient with DC. © 2006 Wiley‐Liss, Inc.
Rescue left main coronary artery stenting for acute myocardial ischemia after coronary angiography in a 7‐year‐old girl with homozygous familial hypercholesterolemia
Authors: Tissot Cecile , Cruz Eduardo da , Aggoun Yacine 
Published: December 2006

AbstractHomozygous familial hypercholesterolemia (HFH), resulting from mutation of the low‐density lipoprotein (LDL) receptor gene with subsequent defective catabolism of the LDL cholesterol, leads to premature atherosclerosis and coronary artery disease. We report a successful urgent stent implantation in a 7‐year‐old patient with HFH and a severe left main coronary artery stenosis, who presented critical acute myocardial ischemia immediately after left coronary angiography. Percutaneous transluminal coronary angiography with stent implantation allowed for rapid coronary flow reestablishment without sequelae. Aggressive lipid‐lowering therapy with high doses statins and LDL‐apheresis was maintained, together with lifelong antiaggregant acetylsalicylic treatment with good short‐term patency of the stent at 1‐year follow‐up. In conclusion, coronary artery stent implantation may be considered as a valid rescue therapeutic alternative for pediatric patients with HFH and severe ostial coronary stenosis in case of emergency. © 2006 Wiley‐Liss, Inc.
A new quantitative analysis system for the evaluation of coronary bifurcation lesions: Comparison with current conventional methods
Authors: Goktekin Omer , Kaplan Sahin , Dimopoulos Konstantinos , Barlis Peter , Tanigawa Jun , Vatankulu Mehmet Akif , Koning Gerhard , Tuinenburg Joan C. , Mario Carlo Di 
Published: December 2006

AbstractBackground:Objective conventional quantitative angiographic systems are designed to automatically follow the contours of straight vascular segments and not of bifurcations. Recently a new analysis method was specifically developed for bifurcation lesions, able to automatically divide the lesion into three separate segments. In this study, we aimed to assess whether the smaller interaction required by the analyst could reduce the analysis time and inter and intra observer variability when compared with a conventional analysis.Method:We used a dedicated system (QVA‐CMS V. 6.0 with the Bifurcation Module, MEDIS, Leiden, The Netherlands) applying a minimum cost algorithm tuned to detect the contours of the proximal main vessel (PMV), distal main vessel (DMV), and side‐branch (SB). We assessed the intra‐ and the interobserver agreement in measurements of minimal lumen diameter (MLD) and percentage diameter stenosis (%DS) of the PMV and DMV, as well as of the SB ostium in 30 angiograms of patients before and after percutaneous coronary angioplasty with stenting of both branches. The consensus between measurements by two observers and by the same observer was analyzed using the intra‐ and interclass correlation coefficient and the reliability coefficients for all measurements. Bland‐Altman plots before and after PCI were also generated to assess the relationship between variability and absolute measurements.Results:Before PCI, intra‐ and interobserver variabilities were consistently lower for the new QVA system, with a significant difference for lesion length in the SB. Post‐PCI data showed a greater variability in the assessment of diameter stenosis with both techniques. The time for analysis was significantly lower both before and after PCI for QVA compared with quantitative coronary angiography (QCA) (4.7 ± 1.1 min versus 6.2 ± 1.3 min, P < 0.0001).Conclusion:Our results demonstrate that this new quantitative bifurcation analysis system can be consistently applied to the analysis of bifurcation lesions before and after angioplasty, with an intra‐ and interobserver reproducibility equal to or better than the conventional analysis system with a significantly shorter analysis time. © 2006 Wiley‐Liss, Inc.
Predictors of restenosis after treatment of bifurcational lesions with paclitaxel eluting stents: A multicenter prospective registry of 150 consecutive patients
Authors: Mario Carlo Di , Morici Nuccia , Godino Cosmo , Goktekin Omer , Tamburino Corrado , Barbagallo Rossella , Antoniucci David , Grube Eberhard , Airoldi Flavio , Zoccai Giuseppe Biondi , Colombo Antonio , Sangiorgi Giuseppe M. 
Published: December 2006

AbstractObjectives:The aim of the study was the assessment of the clinical, angiographic and procedural characteristics correlated with freedom from adverse events at 1 year in a real life setting of consecutive bifurcation lesions. Background: Even if stent implantation has shown to be superior to conventional balloon angioplasty in most coronary lesions, bifurcation treatment with stent implantation both in main and in side branch (SB) still raises controversy. Methods: We reviewed the results obtained in a prospective multicenter registry of 150 patients with 158 bifurcation lesions involving a SB of sufficient diameter to be treated, if necessary, with a polymer based paclitaxel eluting stent (PES, TAXUS). Two stents were used in 118 lesions (74.7%). Final kissing balloon inflation was performed in 87/118 lesions (73.7%) and in 30/40 lesions (75.0%) of the 2 and 1 stent group respectively. Results: At 1‐year clinical follow‐up we observed 4 stent thromboses, all involving the SBs of the 2 stents group (2.7%). Unlike previous reports, revascularization involved the main vessel in the majority of patients (21/150, 14.0%). After an exploratory multivariable analysis the only parameter predictive of target lesion revascularization (TLR) (HR 0.52; CI 95% 0.11–0.86; p = 0.02) and target vessel revascularization (TVR) (HR 0.47; CI 95% 0.14–0.90; p = 0.03) was postprocedural main branch minimal lumen diameter (MB‐MLD). Conclusions: In a real life setting of consecutive bifurcation lesions, thrombosis rate, concentrated in the SB and the 2‐stents group, and need for target lesion revascularization remain higher than in less complex lesion subgroups treated with PES. No differences in immediate success and TLR were observed between 2 stents and 1 stent groups. The frequently observed suboptimal stent expansion and final MB‐MLD predict 1 year revascularization. © 2006 Wiley‐Liss, Inc.
Left ventricular segmental dysfunction following percutaneous transcatheter closure of a membranous ventricular septal defect
Authors: Yalonetsky Sergey , Lorber Avraham 
Published: December 2006

AbstractPercutaneous device closure of membranous ventricular septal defects is an attractive alternative for surgical treatment. A patient with left ventricular segmental dysfunction with infarct like ECG pattern following transcatheter membranous VSD closure is presented. Possible pathophysiological mechanisms of this phenomenon are discussed. © 2006 Wiley‐Liss, Inc.
Interatrial septum rupture during balloon measurement of a patent foramen ovale in a young patient presenting cryptogenic stroke
Authors: Bonvini Robert F. , Sigwart Ulrich , Verin Vitali 
Published: December 2006

AbstractWe report the case of a 36‐year‐old woman admitted for cryptogenic stroke, in whom the Patent Foramen Ovale (PFO) diameter measurement, with a purpose built sizing balloon, performed before the closure procedure, was complicated with the rupture of the inter‐atrial septum generating an Atrial Septal Defect (ASD) with a significant left‐to‐right shunt. This kind of complication may not be easy to handle, changing the initial procedural strategy from PFO to ASD closure technique requiring specific material and operator's technical skill. © 2006 Wiley‐Liss, Inc.
Detection and quantification of embolic particles during percutaneous coronary intervention to stable plaque: It correlates to coronary flow dynamics and myocardial damage
Authors: Okamura Atsunori , Ito Hiroshi , Iwakura Katsuomi , Kawano Shigeo , Kurotobi Toshiya , Date Motoo , Inoue Koichi , Ogihara Toshio , Fujii Kenshi 
Published: December 2006

AbstractObjectives: We detected embolic particles liberated from plaque during percutaneous coronary intervention (PCI) as high‐intensity transient signals (HITS) with a Doppler guidewire and studied their impact on coronary flow dynamics and the myocardium in patients with stable angina pectoris. Background: These embolic particles during PCI may cause myocardial injury. However, this was difficult to confirm because it was impossible to detect embolic particles. Methods: We performed balloon angioplasty followed by stenting in 31 patients while monitoring coronary flow velocity. After PCI, we measured average peak velocity at baseline and after infusion of adenosine 5′‐triphosphate to calculate coronary flow velocity reserve (CFVR) and coronary resistance index (CRI). In patients with PCI to the left coronary artery (n = 21), we calculated relative CFVR as the ratio of CFVR in the target vessel to that in the reference vessel. We measured cardiac troponin T (cTnT) the day after PCI. Results: HITS were detected in 27 (87%) of 31 patients and the majority were observed after stenting. The total number of HITS was correlated with CRI (r = 0.36, P = 0.049) or relative CFVR (r = 0.65, P = 0.0036) but not with CFVR (r = 0.048, P = 0.82). Thirteen patients showed elevated cTnT (range, 0.05–0.31 ng/ml) and the total number of HITS was greater in those with elevated cTnT than in those without elevated cTnT (24 ± 9 vs. 10 ± 7, P = 0.0007). Conclusions: Embolic particles are frequently observed during PCI to stable plaque and the majority are liberated after stenting. There appears to be a quantitative relationship between amounts of HITS and coronary microvessel dysfunction and minor myocardial injury. © 2006 Wiley‐Liss, Inc.
Relocation of minimal luminal diameter after bare metal and drug‐eluting stent implantation: Incidence and impact on angiographic late loss
Authors: Costa Marco A. , Sabaté Manel , Angiolillo Dominick J. , Hu Paula , Jimenez‐Quevedo Pilar , Corros Cecilia , Alfonso Fernando , Hernandez‐Antolin Rosana , Macaya Carlos , Bass Theodore A. 
Published: December 2006

AbstractLate loss (LL) has been a fundamental angiographic end‐point in drug‐eluting stents (DES) clinical trials. However, calculation of LL may be affected by a mismatch between post‐procedure (PO) and follow‐up (FU) sites of the minimal lumen diameter (MLD). Our aims were to investigate the incidence and methodological implications of the relocation of MLD after bare metal (BMS), sirolimus‐eluting (SES), and paclitaxel‐eluting (PES) stent implantation. Data from DIABETES I and II trials, which involved diabetic patients treated with BMS, SES, and PES, were analyzed. Angiographic data with matched projections between PO and 9‐month angiographic FU were included. In‐stent, in‐lesion, and in‐segment analyses included conventional and customized sub‐segmental (5‐mm/subsegment) methodology. MLD relocation was considered when the sites of MLD shifted a distance ≫ the intrinsic variability of the method. Conventional LL, site matched LL, maximal LL (MaxLL), and average LL (AvgLL) were calculated. Relationships between various LL and 1‐year target lesion revascularization (TLR) were investigated. Post MLD was located distally, outside the stent, in ≥65% of the analyses. At FU, MLD relocation occurred in 70.5% (BMS), 40% (SES), and 35% (PES). MLD shifted ≥11 mm on average, mainly towards the stented segment. MLD relocation still occurred in 42.8% (BMS), 33.7% (SES), and 36.4% (PES), when analysis was restricted to in‐stent segment. Among LL measurements, MaxLL showed the best association with TLR rates. Relocation of the MLD is a frequent phenomenon after both BMS and DES, and should be taken into account when calculating LL. Comprehensive LL analyses, including MaxLL and AvgLL, provides a better appraisal of the biological and clinical effectiveness of DES. © 2006 Wiley‐Liss, Inc.
Percutaneous coronary intervention of a circumflex chronic total occlusion using an epicardial collateral retrograde approach
Authors: Lane Rebecca E. , Ilsley Charles D.J. , Wallis William , Dalby Miles C.D. 
Published: December 2006

AbstractAntegrade disobliteration of a chronic total coronary occlusion (CTO) may be technically difficult in spite of the use of customized equipment. Retrograde approaches via intramyocardial septal or bypass grafts have been described. We report a successful Percutaneous intervention of a proximal circumflex CTO using a retrograde approach via an epicardial collateral. © 2006 Wiley‐Liss, Inc.
Diabetes mellitus does not preclude stabilization or improvement of renal function after stent revascularization in patients with kidney insufficiency and renal artery stenosis
Authors: Silva Jose A. , Potluri Srinivas , White Christopher J. , Collins Tyrone J. , Jenkins J. Stephen , Subramanian Rajesh , Ramee Stephen R. 
Published: December 2006

AbstractObjective: To assess the impact of stent revascularization on the renal function of diabetic and nondiabetic patients with renal insufficiency. Background: Renal artery revascularization has been shown to stabilize or improve renal function in patients with significant renal artery stenosis and impaired renal function. However, some studies have suggested negligible or no benefit of renal function in diabetic patients with the same condition. Methods: We retrospectively compared data from 50 consecutive patients undergoing renal artery stent placement with renal insufficiency (serum creatinine ≥1.5–4.0 mg/dl) and global ischemia (bilateral or solitary [single] kidney renal artery stenosis) There were 17 diabetic (DM) and 33 nondiabetic (NDM) patients. The endpoints included the follow‐up measurements of renal function, blood pressure, and number of antihypertensive medications. Results: After stent placement, at a mean follow‐up of 42 ± 18 months (range: 6–62 months), 79% NDM (N = 26), and 76% DM patients (N = 13) (P = NS) had improvement in the slope of the reciprocal of creatinine (1/SCr), indicating a beneficial effect in renal function in many patients. Conclusion: Renal artery stent placement appears to be equally beneficial in preserving renal function in DM and NDM patients with ischemic nephropathy and global renal ischemia. © 2006 Wiley‐Liss, Inc.
Magnetic navigation system used successfully to cross a crushed stent in a bifurcation that failed with conventional wires
Authors: Ramcharitar Steve , Patterson Mark S. , van Geuns Robert‐Jan , Serruys Patrick W. 
Published: December 2006

AbstractBifurcation lesions can be technically demanding to manage, and even in the era of drug eluting stents, their procedural success is variable. The use of the crush technique followed by “kissing” balloon postdilatation has been shown to improve the overall outcome. However, crossing the crushed stent is essential to allow performance of a final dilatation with “kissing” balloons and is regarded as the main Achilles' heel of this technique. In this report, we describe the first reported, planned procedure to use a magnetic navigation system to steer a wire through the crushed stent to use “kissing” balloons that had previously failed with conventional wires. © 2006 Wiley‐Liss, Inc.
Coarctation of the aorta: Stenting in children and adults
Authors: Golden Alex B. , Hellenbrand William E. 
Published: December 2006

AbstractCoarctation of the aorta may present in infants, children, or adults, and it requires treatment to prevent serious morbidity and mortality. Recent advances in equipment and a growing collective experience have made placement of balloon‐expandable stents a safe and effective alternative to surgery or angioplasty in a growing range of patients. This review seeks to provide a working aid for stenting of coarctation of the aorta, based on the techniques and technical considerations in practice at our institution. Between 1989 and 2005, the Congenital Cardiovascular Interventional Study Consortium (CCISC), a consortium of 17 centers, of which our institution is the largest contributor, performed 588 stent placements for coarctation of the aorta. Of the 588 procedures, 580 (98.6%) were successful, as defined by reduction of the gradient to less than 20 mm Hg or increase of the ratio of the diameter of the coarctation area (CoA) to the diameter of the descending aorta (DAo) to at least 0.8. There were a total of 84 complications occurring in 69/588 (11.7%) cases. The most common significant complications were femoral access vessel related 15/588 (2.6%), aneurysm formation 13/588 (2.2%), aortic dissection 9/588 (1.5%), and cerebrovascular accident 6/588 (1.0%). There were two procedure‐related deaths (0.3%) recorded in the 16‐year period. Many of these significant complications occurred in the same patients. Balloon‐expandable stents should be considered a safe and very effective treatment modality in a significant subset of patients with coarctation of the aorta. © 2006 Wiley‐Liss, Inc.
Spontaneous migration of an inferior vena cava filter resulting in cardiac tamponade and percutaneous filter retrieval
Authors: Vergara Gaston R. , Wallace William F. , Bennett Kenneth R. 
Published: December 2006

AbstractThromboembolic disease accounts for thousands of hospitalizations every year in the US. Its primary management consists of anticoagulation. However, in certain instances this may be contraindicated or not sufficient. Mechanic occlusion of the inferior vena cava (IVC) becomes then a viable alternative. In this case a 35‐year‐old man presented with a saddle pulmonary embolus but was unable to be anticoagulated due to intestinal bleed. A removable IVC filter was then placed. The filter spontaneously migrated into the right atrium causing severe tricuspid regurgitation, perforation of the atrial wall, and cardiac tamponade. The device was successfully retrieved percutaneously and the patient discharged from the hospital in stable condition. This case illustrates the potentially lethal complications associated with the use of IVC filters, as well as the possibility to percutaneously recover them from within the right atrium. © 2006 Wiley‐Liss, Inc.
Impact of renal insufficiency on clinical and angiographic outcomes following percutaneous coronary intervention with sirolimus‐eluting stents
Authors: Nakazawa Gaku , Tanabe Kengo , Aoki Jiro , Yamamoto Hirosada , Higashikuni Yasutomi , Onuma Yoshinobu , Yachi Sen , Nakajima Hiroyoshi , Hara, Kazuhiro 
Published: December 2006

AbstractBackgroundBackground: Sirolimus‐eluting stents (SES) have been demonstrated to reduce restenosis. However, there have been few studies evaluating the impact of renal insufficiency on the angiographic as well as clinical outcomes after SES implantation. Methods: This study was composed of 304 consecutive patients having 361 lesions who underwent percutaneous coronary intervention with SES. The patients were divided into 3 groups according to renal function (group 1 [n = 204]; creatinine clearance (Ccr) ≥≥60ml/min, group 2 [n = 69]; Ccr <60 ml/min, group 3 [n = 31]; hemodialysis). Clinical and angiographic follow‐up were evaluated at 8 months. Results: Clinical follow‐up was obtained in all patients and angiographic follow‐up was obtained in 283 patients (93.1%). Patients in group 3 showed a higher incidence of previous coronary artery bypass graft surgery, and there were more female gender, hypertensive, and less hyperlipidemia in this group. Late lumen loss at 8 months was significantly different among the 3 groups (group 1; 0.16 ± 0.46 mm, group 2; 0.44 ± 0.62 mm, group 3; 0.81 ± 0.88 mm, P < 0.0001). Major adverse cardiac events (MACE) were documented in 22 patients (10.8%) in group 1, 13patients (18.8%) in group 2, and 12 patients (38.7%) in group 3, respectively (P = 0.0002). Conclusion: Neointimal growth following SES implantation is more pronounced in patients with renal insufficiency, especially those undergoing dialysis, compared with patients with normal renal function. Regardless of the beneficial effect of SES, the increased risk of MACE mainly due to high incidence of target vessel revascularization in the subgroup of patients with renal insufficiency should be taken into account. © 2006 Wiley‐Liss, Inc.