bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental health and suicide among youth residing in frontier and remote areas
Authors: Kreuze Elizabeth 
Published: April 2024

AbstractAimsExamine state‐level data from the National Survey of Children's Health (NSCH), Youth Risk Behavior Surveillance System (YRBSS), and frontier and remote area (FAR) codes. Compare state‐level data from the NSCH and YRBSS to state's FAR codes, to explore correlations between youth mental health/suicide and geographic remoteness.MethodsState‐level data from the NSCH, YRBSS and FAR codes were organized into tables. For each variable, states were ranked from 1 to 50 and assigned a numeric value. Using this numeric ranking system, Kendall's tau‐b was used to examine correlations between NSCH data and FAR codes, and YRBSS data and FAR codes.ResultsThere were no significant correlations between any FAR level and any NSCH variable. There were significant correlations between level 1 FAR areas and suicidal ideation, suicide planning, and suicide attempt. There were also significant correlations between FAR levels 2, 3, and 4 and suicidal ideation and suicide planning.ConclusionContinued surveillance of youth mental health is important in building the evidence base. However, because suicidal ideation and suicide planning appear higher across all FAR levels, there is opportunity to implement sustainable approaches to prevent suicidal behaviors among youth in FAR areas.
Expression of honey bee (Apis mellifera) sterol homeostasis genes in food jelly producing glands of workers
Authors: Yusuf Abdullahi A. , Pirk Christian W. W. , Buttstedt Anja 
Published: April 2024

AbstractAdult workers of Western honey bees (Apis mellifera L.) acquire sterols from their pollen diet. These food sterols are transported by the hemolymph to peripheral tissues such as the mandibular and the hypopharyngeal glands in the worker bees' heads that secrete food jelly which is fed to developing larvae. As sterols are obligatory components of biological membranes and essential precursors for molting hormone synthesis in insects, they are indispensable to normal larval development. Thus, the study of sterol delivery to larvae is important for a full understanding of honey bee larval nutrition and development. Whereas hypopharyngeal glands only require sterols for their membrane integrity, mandibular glands add sterols, primarily 24‐methylenecholesterol, to its secretion. For this, sterols must be transported through the glandular epithelial cells. We have analyzed for the first time in A. mellifera the expression of genes which are involved in intracellular movement of sterols. Mandibular and hypopharyngeal glands were dissected from newly emerged bees, 6‐day‐old nurse bees that feed larvae and 26‐day‐old forager bees. The expression of seven genes involved in intracellular sterol metabolism was measured with quantitative real‐time PCR. Relative transcript abundance of sterol metabolism genes was significantly influenced by the age of workers and specific genes but not by gland type. Newly emerged bees had significantly more transcripts for six out of seven genes than older bees indicating that the bulk of the proteins needed for sterol metabolism are produced directly after emergence.
Unusually weak signal of summer surface air temperature change over North China
Authors: Cheng Fangyuan , Zuo Zhiyan , Zhang Kaiwen , Chang Meiyu , Xiao Dong 
Published: April 2024

AbstractUnder global warming, the summer surface air temperature (SAT) change signal in the northern mid‐latitudes is generally the most significant, while the SAT change in North China (NC) shows distinct local characteristics. Using simulations from the Coupled Model Intercomparison Project Phase 6 and observation from Berkeley Earth Surface Temperature, this study reveals an unusually weak signal of summer SAT change in NC since the 1960s. This uniquely weak signal can be attributed to the small net contribution of external forcings, mainly from anthropogenic greenhouse gases (GHG) and aerosols (AA). Compared to other land regions in the same latitudinal band, the GHG‐induced warming was weaker and AA‐induced cooling was stronger in NC, resulting in the weakest SAT change signal and thus the lowest signal‐to‐noise ratio. This weaker GHG‐induced warming plays a more important role in the SAT change difference between NC and other land regions in the same latitudinal zone. Under different emission scenarios in the future, the signal‐to‐noise ratio in NC will become as large as those in the other land regions in the same latitudinal band and the northern hemisphere, which is partly due to the smaller relative differences in the SAT change signal between NC and the other two regions. The projections of SAT change indicate that climate change in NC will probably become more violent and vulnerable.
Preparation and functional properties of rice bran globulin‐chitooligosaccharide‐quercetin‐resveratrol covalent complex
Authors: Zhang Fengjiao , Liu Jinguang , Uyanga Victoria Anthony , Tang Caiyun , Qu Yanan , Qin Xu , Chen Yilun , Liu Yuqian 
Published: April 2024

AbstractBACKGROUNDAs the major protein (approximately 36%) in rice bran, globulin exhibits excellent foaming and emulsifying properties, endowing its useful application as a foaming and emulsifying agent in the food industry. However, the low water solubility restricts its commercial potential in industrial applications. The present study aimed to improve this protein's processing and functional properties.RESULTSA novel covalent complex was fabricated by a combination of the Maillard reaction and alkaline oxidation using rice bran globulin (RBG), chitooligosaccharide (C), quercetin (Que) and resveratrol (Res). The Maillard reaction improved the solubility, emulsifying and foaming properties of RBG. The resultant glycosylated protein was covalently bonded with quercetin and resveratrol to form a (RBG‐C)‐Que‐Res complex. (RBG‐C)‐Que‐Res exhibited higher thermal stability and antioxidant ability than the native protein, binary globulin‐chitooligosaccharide or ternary globulin‐chitooligosaccharide‐polyphenol (only containing quercetin or resveratrol) conjugates. (RBG‐C)‐Que‐Res exerted better cytoprotection against the generation of malondialdehyde and reactive oxygen species in HepG2 cells, which was associated with increased activities of antioxidative enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH‐Px) through upregulated genes SOD1, CAT, GPX1 (i.e. gene for glutathione peroxidase‐1), GCLM (i.e. gene for glutamate cysteine ligase modifier subunit), SLC1A11 (i.e. gene for solute carrier family 7, member 11) and SRXN1 (i.e. gene for sulfiredoxin‐1). The anti‐apoptotic effect of (RBG‐C)‐Que‐Res was confirmed by the downregulation of caspase‐3 and p53 and the upregulation of B‐cell lymphoma‐2 gene expression.CONCLUSIONThe present study highlights the potential of (RBG‐C)‐Que‐Res conjugates as functional ingredients in healthy foods. © 2024 Society of Chemical Industry.
Histological analysis of nucleus pulposus tissue from patients with lumbar disc herniation after condoliase administration
Authors: Minamisawa Yuka , Shirogane Taiichi , Watanabe Ippei , Dezawa Akira 
Published: April 2024

AbstractBackgroundCondoliase is an enzyme used as a treatment for lumbar disc herniation (LDH). This enzyme degrades chondroitin sulfate (CS) in the nucleus pulposus of the intervertebral disc (IVD). However, there are cases in which symptoms do not improve, despite condoliase administration. This study reports histological analysis of lumbar disc tissue of LDH patients who underwent surgery because condoliase had no therapeutic effect.MethodsBetween March 2019 and August 2019, 12 LDH patients who underwent full endoscopic spine surgery (FESS) discectomy at the Dezawa Akira PED Clinic were the subjects of the study. There are two study groups: six cases underwent FESS after condoliase administration, while six underwent FESS without condoliase administration. The average duration from drug administration to surgery was 152 days. Herniated disc removed at surgery was evaluated by histological staining including immunohistochemistry by anti‐CS antibodies.ResultsMultiple large clusters (40–120 μm in diameter) were observed in the nucleus pulposus of those who received condoliase, but no clusters were observed in those who did not. The lumbar disc tissues, including the nucleus pulposus of recipients, were stained with anti‐CS antibodies that recognize the CS unsaturated disaccharide, but non‐administration tissue was not stained. These findings suggest that the enzyme acted on the nucleus pulposus, even in cases where symptoms were not improved by condoliase administration. Furthermore, there was no histological difference between stained images of the extracellular matrix in those who did or did not receive condoliase, suggesting that condoliase acted specifically on CS in the nucleus pulposus.ConclusionsWe demonstrated that CS in the nucleus pulposus was degraded in patients in whom condoliase did not have a therapeutic effect. Moreover, condoliase acts in human IVD without causing necrosis of chondrocytes and surrounding tissues.
Comparison of Left Ventricular Stroke Volume in 2nd‐ and 3rd‐Trimester Fetuses Measured by the Product of VTI and Aortic Annular Area With That Assessed by Simpson's Single‐Plane Rule Using the STE Technique
Authors: Serafin Krzysztof , Nocun Agnieszka A. , Zawisza Katarzyna , Dudzik Magdalena M. , Wiechec Marcin T. 
Published: April 2024

ObjectivesThe aim of the study was to compare left ventricle stroke volume in healthy, eutrophic fetuses in the 2nd and 3rd trimesters evaluated using the velocity time integral and aortic annulus area with left ventricular stroke volume measured using Simpson's single‐plane rule and to determine the discrepancy equation.MethodsThe study included 354 fetuses. In each fetus, during the same examination, simultaneous assessment of stroke volume was performed by pulsed‐wave Doppler using the product of the velocity time integral and aortic annulus area and by the fetalHQ® software using Simpson's single‐plane rule. The Mann–Whitney U test was used to compare the “product‐derived” stroke volume and stroke volume using fetalHQ® software values in the 2nd and 3rd trimesters separately. The agreement between the two methods were verified using Bland–Altman analysis. A linear regression model was used to obtain the discrepancy equation.ResultsIn the 2nd trimester, the mean percentage difference between both the techniques showed that the stroke volume values determined using pulsed‐wave Doppler were, on average, 88% higher than the stroke volume values determined using fetalHQ®. The upper limit of agreement between the compared techniques was approximately 146% and the lower limit of agreement was equal to 29.6%. In the 3rd trimester, the results indicated that the stroke volume values determined using pulsed‐wave Doppler were, on average, 76% higher than the stroke volume values determined using fetalHQ®. The upper limit of agreement between the compared techniques was approximately 129% and the lower limit of agreement was 23%. Based on the results of the linear regression models, discrepancy formulas of the stroke volume values were obtained. The equations to calculate the predicted mean and standard deviations were used to compute the reference intervals for the mean, 5th and 95th centiles.ConclusionThe calculation of left ventricular stroke volume using pulsed Doppler has higher result in relation to stroke volume determined using Simpson's rule significantly. The aortic annulus area showed a higher correlation regarding stroke volume than the velocity time integral in both the 2nd and 3rd trimesters. Stroke volume increased with the increase in aortic annulus area, whereas the velocity time integral remained relatively constant. The retrospective analysis of the collected material enabled the determination of the discrepancy equation.
Sociodemographic and Healthcare System Barriers to PAP Alternatives for Adult OSA: A Scoping Review
Authors: Singh Amritpal , Bhat Amrita , Saroya Jasmeet , Chang Jolie , Durr Megan L. 
Published: April 2024

ObjectiveTo investigate sociodemographic and healthcare system barriers to access and utilization of alternative treatments to positive airway pressure (PAP) in the management of adult obstructive sleep apnea (OSA).Data SourcesPubMed, Embase, and Web of Science databases were searched from 2003 to 2023 for English‐language studies containing original data on sociodemographic and healthcare system barriers to PAP‐alternative treatments for adult OSA.Review MethodsStudies were assessed using the Preferred Reporting Items for Systematic Reviews and Meta‐analyses Extension for Scoping Reviews (PRISMA‐ScR) guidelines. Title and abstract screening, full‐text review, and data collection were conducted by two investigators independently.ResultsOut of 1,615 studies screened, 13 studies met inclusion criteria and reported on a total of 1,206,115 patients who received PAP alternative treatments, including surgery (n = 9 studies), and oral appliances (OAs) (n = 3 studies). The chance of receiving a PAP‐alternative treatment such as surgery was greater among patients aged 39 years or younger, had body mass index below 30 kg/m2, fewer comorbidities, private insurance, and a higher occupational and income status. The decision of individuals to receive PAP alternative treatments was influenced by increased patient education from providers, as well as improvements in daytime sleepiness and partner perception of snoring and apnea.ConclusionCumulative evidence suggests that several sociodemographic and healthcare system factors are associated with decreased use of PAP alternatives when PAP therapy fails. Investigation of interventions to eliminate these potential barriers may improve access and treatment outcomes. Laryngoscope, 134:3903–3909, 2024
Peptoid‐Cross‐Linked Hydrogel Stiffness Modulates Human Mesenchymal Stromal Cell Immunoregulatory Potential in the Presence of Interferon‐Gamma
Authors: Castilla‐Casadiego David A. , Morton Logan D. , Loh Darren H. , Pineda‐Hernandez Aldaly , Chavda Ajay P. , Garcia Francis , Rosales Adrianne M. 
Published: April 2024

AbstractHuman mesenchymal stromal cell (hMSC) manufacturing requires the production of large numbers of therapeutically potent cells. Licensing with soluble cytokines improves hMSC therapeutic potency by enhancing secretion of immunoactive factors but typically decreases proliferative ability. Soft hydrogels, however, have shown promise for boosting immunomodulatory potential, which may compensate for decreased proliferation. Here, hydrogels are cross‐linked with peptoids of different secondary structures to generate substrates of various bulk stiffnesses but fixed network connectivity. Secretions of interleukin 6, monocyte chemoattractive protein‐1, macrophage colony‐stimulating factor, and vascular endothelial growth factor are shown to depend on hydrogel stiffness in the presence of interferon gamma (IFN‐γ) supplementation, with soft substrates further improving secretion. The immunological function of these secreted cytokines is then investigated via coculture of hMSCs seeded on hydrogels with primary peripheral blood mononuclear cells (PBMCs) in the presence and absence of IFN‐γ. Cocultures with hMSCs seeded on softer hydrogels show decreased PBMC proliferation with IFN‐γ. To probe possible signaling pathways, immunofluorescent studies probe the nuclear factor kappa B pathway and demonstrate that IFN‐γ supplementation and softer hydrogel mechanics lead to higher activation of this pathway. Overall, these studies may allow for production of more efficacious therapeutic hMSCs in the presence of IFN‐γ.
Reconfigurable Cellulose Acetate‐Based Thermosets Cross‐Linked with Diboronic Acid
Authors: Fu Yangkang , Wang Hao , Xu Mengli , Wen Peng , Zheng Han , Xie Jiao , Chen Mao 
Published: April 2024

AbstractCellulose acetate (CA) has found broad applications for many years. However, the development of mechanically strengthened CA materials without losing the processibility in solution remains quite difficult. In this work, novel CA thermosets are reported that can be readily constructed by employing alkyl diboronic acid as a crosslinking agent, which has allowed convenient reconfiguration of CA networks without demanding catalysts or harsh processing conditions. Various properties including thermal stability, creeping resistance, rheological and mechanical strength have been successfully improved by using small amounts (1–5 wt%) of diboronic acid. The dynamic cross‐linked network based on boron chemistry has facilitated solution processing during three times of recycling. Control experiments have shown that alkyl diboronic acid can deliver superior mechanical strength to CA as compared to aryl diboronic acid or single‐arm alkyl boronic acid. Based on the importance of CA materials, this work should be attractive to the design of reprocessible CA thermosets with high performance.
Polylactic‐Acid Having MoS2 Particles for Reversible Bilayer Actuators
Authors: Nolasco Cristobal , Flores Loreto , Palza Humberto 
Published: April 2024

AbstractPolylactic acid (PLA) composites having 1 wt% of MoS2 particles are prepared by solvent (SM) and melt mixing (MM) methods and their main thermal and mechanical properties are characterized. Coated films from SM samples and 3D‐printed filaments from MM samples are tested as active layers in reversible bilayer actuators using a paper sheet as a passive layer. The thermal properties depend on the method used to prepare the composites with MM samples presenting a cold crystallization and a glass transition during the first and second heating and SM samples displaying a standard melt process during the first heating and a small cold crystallization and a glass transition during second heating. Regarding the stiffness, MoS2 increases this property confirming its reinforcement effect. Both kinds of bilayers show reversible actuation under heating either by putting the actuator on a hot plate or by remotely irradiating the sample with near‐infrared light (NIR). Under NIR, the 3D printed composites present a much higher actuation. The higher remote actuation in composited bilayers is explained by the NIR light absorption of the MoS2 photoactive particles. This actuator can be used for the design of a smart façade or blind that closes under NIR stimulus.
Investigation of Mechanical Properties of Nonwoven Recycled Cotton/PET Fiber‐Reinforced Polyester Hybrid Composites
Authors: Dev Barshan , Rahman Md Ashikur , Tazrin Tasnima , Islam Md Shahinul , Datta Anirban , Rahman Md Zillur 
Published: April 2024

AbstractThis study investigates the mechanical properties of nonwoven hybrid composites made from recycled cotton/polyethylene terephthalate (PET) with various fiber weight percentages (100/0, 0/100, 75/25, 60/40, 50/70, 60/40, and 25/75). The multilayered nonwoven carded webs are manufactured by the carding machine, while the manual lay‐up technique is used to fabricate nonwoven‐reinforced composites. Their tensile, flexural, and impact properties and microstructure are then examined. It is found that the tensile modulus and strength increase with the increase in cotton, while the impact strength improves with the increase in PET. The composite of 75% cotton/25% PET offers 92.13% and 67.87% higher tensile modulus and strength than the composite of 25% cotton/75% PET; however, the composite of 25% cotton/75% PET shows 83.09% and 36.22% higher flexural modulus and strength, and 187% more impact strength, respectively, than the composite of 75% cotton/25% PET. The outcome of this study indicates that nonwoven composites with higher contents of recycled cotton can potentially be applied in building and construction sectors where substantial tensile strength is necessary, while composites with comparatively higher contents of recycled PET may be used for various potential applications (e.g., helmets, surfboards, and automotive interiors) where significant flexural and impact strengths are required.
Artiruno: A free‐software tool for multi‐criteria decision‐making with verbal decision analysis
Authors: Arfer Kodi B. 
Published: April 2024

AbstractVerbal decision analysis (VDA) is a family of methods for multi‐criteria decision analysis that require no numerical judgements from the agent. Although many such methods have been developed, they share the potential issue of asking the agent many more questions than necessary, particularly under multilevel approaches. Furthermore, whether VDA improves decisions, compared to no intervention, has yet to be investigated empirically. I introduce a new VDA method, Artiruno, with a freely licensed implementation in Python. Artiruno makes inferences mid‐interview so as to require minimal input from the agent, while using a multilevel scheme that allows it to ask complex questions when necessary. Inferences are facilitated by an axiom allowing comparisons to be partitioned across groups of criteria. Artiruno's performance in a variety of simple and complex scenarios can be verified with automated software tests. For an empirical test, I conducted an experiment in which 107 people from an Internet subject pool considered an important decision they faced in their own lives, and were randomly assigned to use Artiruno or to receive no intervention. These subjects proved mostly able to use Artiruno, and they found it helpful, but Artiruno seemed to have little influence on their decisions or outcomes.
Percutaneous left atrial appendage occlusion and risk of stroke, hospitalized bleeding and death in Medicare beneficiaries
Authors: Wang Wendy , Chen Lin Yee , Walker Rob F. , Alonso Alvaro , Norby Faye L. , Lakshminarayan Kamakshi , Lutsey Pamela L. 
Published: April 2024

AbstractPurposeAmong patients with atrial fibrillation (AF), a nonpharmacologic option (e.g., percutaneous left atrial appendage occlusion [LAAO]) is needed for patients with oral anticoagulant (OAC) contraindications. Among beneficiaries in the Medicare fee‐for‐service coverage 20% sample databases (2015–18) who had AF and an elevated CHA2DS2‐VASc score, we assessed the association between percutaneous LAAO versus OAC use and risk of stroke, hospitalized bleeding, and death.MethodsPatients undergoing percutaneous LAAO were matched to up to five OAC users by sex, age, date of enrollment, index date, CHA2DS2‐VASc score, and HAS‐BLED score. Overall, 17 156 patients with AF (2905 with percutaneous LAAO) were matched (average ± SD 78 ± 6 years, 44% female). Cox proportional hazards model were used.ResultsMedian follow‐up was 10.3 months. After multivariable adjustments, no significant difference for risk of stroke or death was noted when patients with percutaneous LAAO were compared with OAC users (HRs [95% CIs]: 1.14 [0.86–1.52], 0.98 [0.86–1.10]). There was a 2.94‐fold (95% CI: 2.50–3.45) increased risk for hospitalized bleeding for percutaneous LAAO compared with OAC use. Among patients 65 to <78 years old, those undergoing percutaneous LAAO had higher risk of stroke compared with OAC users. No association was present in those ≥78 years.ConclusionIn this analysis of real‐world AF patients, percutaneous LAAO versus OAC use was associated with similar risk of death, nonsignificantly elevated risk of stroke, and an elevated risk of bleeding in the post‐procedural period. Overall, these results support results of randomized trials that percutaneous LAAO may be an alternative to OAC use for patients with contraindications.