bluuebunny/crossref_metadata_2025_split huggingface dataset:
Room Temperature Crystallized Phase‐Pure α‐FAPbI3 Perovskite with In‐Situ Grain‐Boundary Passivation
Authors: Shi Zejiao , Wang Yaxin , Wang Yanyan , Li Xiaoguo , Yue Xiaofei , Wang Haoliang , Zhang Xin , Deng Liangliang , Li Chongyuan , Wang Jiao , Xie Zuoti , Yang Yinguo , Cong Chunxiao , Yu Anran , Zhan Yiqiang 
Published: March 2024

AbstractEnergy loss in perovskite grain boundaries (GBs) is a primary limitation toward high‐efficiency perovskite solar cells (PSCs). Two critical strategies to address this issue are high‐quality crystallization and passivation of GBs. However, the established methods are generally carried out discretely due to the complicated mechanisms of grain growth and defect formation. In this study, a combined method is proposed by introducing 3,4,5‐Trifluoroaniline iodide (TFAI) into the perovskite precursor. The TFAI triggers the union of nano‐sized colloids into microclusters and facilitates the complete phase transition of α‐FAPbI3 at room temperature. The controlled chemical reactivity and strong steric hindrance effect enable the fixed location of TFAI and suppress defects at GBs. This combination of well‐crystallized perovskite grains and effectively passivated GBs leads to an improvement in the open circuit voltage (Voc) of PSCs from 1.08 V to 1.17 V, which is one of the highest recorded Voc without interface modification. The TFAI‐incorporated device achieved a champion PCE of 24.81%. The device maintained a steady power output near its maximum power output point, showing almost no decay over 280 h testing without pre‐processing.
Is investing in food small and medium enterprises a viable path to improved nutrition in Sub‐Saharan Africa? A multidisciplinary perspective
Authors: Chapple Alice , Reynolds Elise , Mude Andrew , Riaz Warda , Engle‐Stone Reina 
Published: March 2024

AbstractThrough the perspectives of impact investors, and the nutrition community, this paper explores whether impact investment in food‐related small and medium enterprises (SMEs) creates a viable path to improved nutrition in Sub‐Saharan Africa. From the nutrition perspective, investment in food SMEs could help address coexisting multiple forms of malnutrition by shifting nutritional quality of available foods. From the investor perspective, attractiveness of investment in food SMEs depends on financial risks, how costs are passed on to consumers, and probability of impact. Clear nutritional objectives and investment criteria are needed, as well as research to maximize the potential of this innovative approach.
Polyhalogenated 2‐Azabicyclo[2.2.1]heptanes from Polyhaloaldimines and Cyclopentadiene via Cycloaddition and Wagner‐Meerwein Rearrangement
Authors: Chernysheva Gulnur N. , Katerinich Maxim D. , Ushakov Igor A. , Borodina Tatiana N. , Smirnov Vladimir I. , Rozentsveig Igor B. 
Published: March 2024

Abstract2‐Arylsulfonyl‐2‐azabicyclo[2.2.1]hept‐5‐enes, synthesized via the cycloaddition of chloral‐ or dichloro(phenyl)acetaldehyde N‐arylsulfonylimines to cyclopentadiene, undergo Wagner‐Meerwein rearrangement under the action of bromine or chlorine to afford 3‐polychloro‐6,7‐dyhalogenated 2‐arylsulfonylazabicyclo[2.2.1]heptanes.
Racial, ethnic, and rural disparities in distance to physicians among decedents with Alzheimer's disease and related dementias in Washington State
Authors: Amiri Solmaz , Keffeler Jonae I. , Crain Dennis R. , Denney Justin T. , Buchwald Dedra 
Published: March 2024

AbstractINTRODUCTIONDistance to physicians may explain some of the disparities in Alzheimer's disease and related dementia (AD/ADRD) outcomes.METHODSWe generated round trip distance between residences of decedents with AD/ADRD and the nearest neurologist and primary care physician in Washington State.RESULTSThe overall mean distance to the nearest neurologist and primary care physician was 17 and 4 miles, respectively. Non‐Hispanic American Indian and/or Alaska Native and Hispanic decedents would have had to travel 1.12 and 1.07 times farther, respectively, to reach the nearest neurologist compared to non‐Hispanic White people. Decedents in micropolitan, small town, and rural areas would have had to travel 2.12 to 4.01 times farther to reach the nearest neurologist and 1.14 to 3.32 times farther to reach the nearest primary care physician than those in metropolitan areas.DISCUSSIONThese results underscore the critical need to identify strategies to improve access to specialists and primary care physicians to improve AD/ADRD outcomes.Highlights
Distance to neurologists and primary care physicians among decedents with AD/ADRD
American Indian and/or Alaska Native decedents lived further away from neurologists
Hispanic decedents lived further away from neurologists
Non‐metropolitan decedents lived further away from neurologists and primary care
Decrease distance to physicians to improve dementia outcomes
Age of Alzheimer's disease diagnosis in people with Down syndrome and associated factors: Results from the Horizon 21 European Down syndrome consortium
Authors: Larsen Frode Kibsgaard , Baksh R. Asaad , McGlinchey Eimear , Langballe Ellen Melbye , Benejam Bessy , Beresford‐Webb Jessica , McCarron Mary , Coppus Antonia , Falquero Segolene , Fortea Juan , Levin Johannes , Loosli Sandra V. , Mark Ruth , Rebillat Anne‐Sophie , Zaman Shahid , Strydom Andre 
Published: March 2024

AbstractINTRODUCTIONPeople with Down syndrome (DS) have high risk of developing Alzheimer's disease (AD). This study examined mean ages of AD diagnosis and associations with co‐occurring conditions among adults with DS from five European countries.METHODSData from 1335 people with DS from the Horizon 21 European DS Consortium were used for the analysis.RESULTSMean ages of AD diagnosis ranged between 51.4 (SD 7.0) years (United Kingdom) and 55.6 (SD 6.8) years (France). Sleep‐related and mental health problems were associated with earlier age of AD diagnosis. The higher number of co‐occurring conditions the more likely the person with DS is diagnosed with AD at an earlier age.DISCUSSIONMean age of AD diagnosis in DS was relatively consistent across countries. However, co‐occurring conditions varied and impacted on age of diagnosis, suggesting that improvements can be made in diagnosing and managing these conditions to delay onset of AD in DS.Highlights
Mean age of AD diagnosis was relatively consistent between countries
Sleep problems and mental health problems were associated with earlier age of AD diagnosis
APOE ε4 carriers were diagnosed with AD at an earlier age compared to non‐carriers
Number of co‐occurring conditions was associated with earlier age of AD diagnosis
No differences between level of intellectual disability and mean age of AD diagnosis
The Abca7V1613M variant reduces Aβ generation, plaque load, and neuronal damage
Authors: Butler Claire A. , Mendoza Arvilla Adrian , Milinkeviciute Giedre , Da Cunha Celia , Kawauchi Shimako , Rezaie Narges , Liang Heidi Y. , Javonillo Dominic , Thach Annie , Wang Shuling , Collins Sherilyn , Walker Amber , Shi Kai‐Xuan , Neumann Jonathan , Gomez‐Arboledas Angela , Henningfield Caden M. , Hohsfield Lindsay A. , Mapstone Mark , Tenner Andrea J. , LaFerla Frank M. , Mortazavi Ali , MacGregor Grant R. , Green Kim N. 
Published: March 2024

AbstractBACKGROUNDVariants in ABCA7, a member of the ABC transporter superfamily, have been associated with increased risk for developing late onset Alzheimer's disease (LOAD).METHODSCRISPR‐Cas9 was used to generate an Abca7V1613M variant in mice, modeling the homologous human ABCA7V1599M variant, and extensive characterization was performed.RESULTSAbca7V1613M microglia show differential gene expression profiles upon lipopolysaccharide challenge and increased phagocytic capacity. Homozygous Abca7V1613M mice display elevated circulating cholesterol and altered brain lipid composition. When crossed with 5xFAD mice, homozygous Abca7V1613M mice display fewer Thioflavin S‐positive plaques, decreased amyloid beta (Aβ) peptides, and altered amyloid precursor protein processing and trafficking. They also exhibit reduced Aβ‐associated inflammation, gliosis, and neuronal damage.DISCUSSIONOverall, homozygosity for the Abca7V1613M variant influences phagocytosis, response to inflammation, lipid metabolism, Aβ pathology, and neuronal damage in mice. This variant may confer a gain of function and offer a protective effect against Alzheimer's disease‐related pathology.Highlights
ABCA7 recognized as a top 10 risk gene for developing Alzheimer's disease.
Loss of function mutations result in increased risk for LOAD.
V1613M variant reduces amyloid beta plaque burden in 5xFAD mice.
V1613M variant modulates APP processing and trafficking in 5xFAD mice.
V1613M variant reduces amyloid beta‐associated damage in 5xFAD mice.
Feasibility study on titanium‐catalyzed polyester for the preparation of high‐strength industrial yarns
Authors: Guan Zhenyu , Sun Na , Zhang Yue , Song Minggen , Zhou Wenle , Zhang Yumei 
Published: March 2024

AbstractIn order to overcome the environmental pollution or personal injury caused by precipitation of heavy metal ions during post‐processing and application of antimony‐catalyzed polyester industrial yarns, the titanium catalyst was used to prepare polyethylene terephthalate (PET) with high molecular weight, and then the titanium‐ catalyzed PET properties related to spinning kinetics were investigated as a basis for designing the drying, melting, spinning and extrusion, cooling, hot stretching and heat‐ setting process parameters. Compared with the spinning process of antimony‐catalyzed polyester of similar molecular weight, based on the lower melting point and melt viscosity of titanium‐catalyzed PET, the spinning temperature was lowered by about 5°C to reduce the thermal degradation of PET during extrusion, and the hot stretching speed and temperature were appropriately lowered based on the characteristics of low crystallization temperature and high crystallization rate in the heating process so that a product with a breaking strength of 8.29 cN/dtex was developed on an industrial device successfully. Titanium‐catalyzed high‐strength polyester industrial yarns, the structure and properties of crystal orientation, lamellar thickness, strength and elongation at break were comparable with those of antimony‐catalyzed polyester industrial yarns.
A perovskite‐based electrochemiluminescence aptasensor for tetracycline screening
Authors: Chen Yuxin , Zhong Xinyi , Yang Qiling , Chen Huiping , Hao Nan , Hu Shanwen 
Published: March 2024

AbstractTetracyclines are currently the most commonly used class of antibiotics, and their residue issue significantly impacts public health safety. In this study, a surface modification of perovskite with cetyltrimethylammonium bromide led to the generation of stable electrochemiluminescence (ECL) emitters in aqueous systems and improved the biocompatibility of perovskite. A perovskite quantum dot‐based ECL sensing strategy was developed. Utilizing the corresponding aptamer of the antibiotics, strain displacement reactions were triggered, disrupting the ECL quenching system composed of perovskite and Ag nanoclusters (Ag NCs) on the electrode surface, generating a signal to achieve quantitative detection of several common tetracycline antibiotics. The perovskite quantum dot provided a strong and stable initial signal, while the efficient catalytic activity of the silver cluster enhanced the recognition sensitivity. Tetracycline, chlortetracycline, and oxytetracycline were used as examples to demonstrate the differentiation and quantitative detection through this method. In addition, the aptasensor exhibited analytical performance with the linear range (0.1–10 μM OTC) and good recovery rates of 94.7% to 101.6% in real samples. This approach has the potential to become a sensitive and practical approach for assessing antibiotic residues.
A tale of two platforms: A comparative analysis of language use in consumer complaints on Reddit and Spotify Community
Authors: Yin Qian , Sadowski Sebastian 
Published: March 2024

AbstractConsumer complaints play a crucial role for companies in understanding customer needs and spotting possible areas of improvement. In the digital era, online platforms have become popular venues for users to voice their concerns. According to Communication Accommodation Theory (CAT) and recipient design, consumers may have different recipients in mind when writing a complaint and tailor their language accordingly. This study aims to examine language variations in consumer complaints on an independent platform and a corporate platform, exploring how consumers adjust their language based on the intended recipients of their complaints. Comments under complaint posts from Reddit's dedicated subreddit, r/Spotify, and from the Spotify Community were extracted and analyzed using the Linguistic Inquiry and Word Count (LIWC), a text analysis tool. This comparative analysis identified and compared various linguistic categories within the consumer complaints from the perspectives of formality, emotion, and assertion. The results showed that complaints on the corporate platform (1) used more formal language, (2) contained more negative emotional tones and emotion words, and (3) exhibited more assertiveness compared to those on the independent platform. Understanding the distinct linguistic features in consumer complaints on different platforms can help companies tailor their responses and address customer concerns effectively. This research contributes to the growing field of online consumer complaining behavior by uncovering how language is employed within different online communities depending on the message recipient. Furthermore, it demonstrates the potential of LIWC as a valuable tool for analyzing unstructured consumer‐generated content across diverse digital platforms, offering insights into user sentiment and experiences.
64Cu tumor labeling with hexadentate picolinic acid‐based bispidine immunoconjugates
Authors: Kubeil Manja , Neuber Christin , Starke Miriam , Arndt Claudia , Rodrigues Loureiro Liliana , Hoffmann Lydia , Feldmann Anja , Bachmann Michael , Pietzsch Jens , Comba Peter , Stephan Holger 
Published: March 2024

AbstractDiscussed are two picolinate appended bispidine ligands (3,7‐diazabicyclo[3.3.1]nonane derivatives) in comparison with an earlier described bis‐pyridine derivative, which are all known to strongly bind CuII. The radiopharmacological characterization of the two isomeric bispidine complexes includes quantitative labeling with 64CuII at ambient conditions with high radiochemical purities and yields (molar activities >200 MBq/nmol). Challenge experiments in presence of EDTA, cyclam, human serum and SOD demonstrate high stability and inertness of the 64Cu‐bispidine complexes. Biodistribution studies performed in Wistar rats indicate a rapid renal elimination for both 64Cu‐labeled chelates. The bispidine ligand with the picolinate group in N7 position was selected for further biological experiments, and its backbone was therefore substituted with a benzyl‐NCS group at C9. Two tumor target modules (TMs), targeting prostate stem cell antigen (PSCA), overexpressed in prostate cancer, and the fibroblast activation protein (FAP) in fibrosarcoma, were selected for thiourea coupling with the NCS‐functionalized ligand and lysine residues of TMs. Small animal PET experiments on tumor‐bearing mice showed specific accumulation of the 64Cu‐labeled TMs in PSCA‐ and FAP‐overexpressing tumors (standardized uptake value (SUV) for PC3: 2.7±0.6 and HT1080: 7.2±1.25) with almost no uptake in wild type tumors.
Natural Distribution, Structures, Synthesis, and Bioactivity of Hasubanan Alkaloids
Authors: Wang Yingjie , Sun Fuxin , Liang Yapeng , Zhou Di , Chen Gang , Li Ning 
Published: March 2024

AbstractHasubanan alkaloids represent a distinct class of alkaloids bearing a structural resemblance to morphine, predominantly found in herbals of the Stephania genus. Their intriguing molecular architecture and potential analgesic properties have captured the interest of medicinal chemists worldwide. This review meticulously examines the natural distribution, structural characteristics, biosynthetic pathways, synthetic methodologies, and biological activities of hasubanans.
Chemical Modifications in Hyaluronic Acid‐Based Electrospun Scaffolds
Authors: Pepe Antonietta , Laezza Antonio , Armiento Francesca , Bochicchio Brigida 
Published: March 2024

AbstractHyaluronic acid (HA) is a natural, non‐sulfated glycosaminoglycan (GAG) present in ECM. It is involved in different biological functions with appealing properties in cosmetics and pharmaceutical preparations as well as in tissue engineering. Generally, HA has been electrospun in blends with natural or synthetic polymers to produce fibers having diameters in the order of nano and micro‐scale whose pores can host cells able to regenerate damaged tissues. In the last decade, a rich literature on electrospun HA‐based materials arose. Chemical modifications were generally introduced in HA scaffolds to favour crosslinking or conjugation with bioactive molecules. Considering the high solubility of HA in water, HA‐based electrospun scaffolds are cross‐linked to increase the stability in biological fluids. Crosslinking is necessary also to avoid the release of HA from the hybrid scaffold when implanted in‐vivo. Furthermore, to endow the HA based scaffolds with new chemical or biological properties, conjugation of bioactive molecules to HA was widely reported. Herein, we review the existing research classifying chemical modifications on HA and HA‐based electrospun fibers into three categories: i) in‐situ crosslinking of electrospun HA‐based scaffolds ii) off‐site crosslinking of electrospun HA‐based scaffolds; iii) conjugation of biofunctional molecules to HA with focus on peptides.
Selective Recovery of Battery‐Grade Li2CO3 from Spent NCM Cathode Materials Using a One‐Step Method of CO2 Carbonation Recovery Without Acids or Bases
Authors: Ma Wenjun , Liang Zhiyuan , Zhang Xu , Liu Yidi , Zhao Qinxin 
Published: March 2024

AbstractThe recovery of spent lithium‐ion batteries by traditional acid leaching is limited by serious pollution, complicated technology, and the low purity of Li2CO3. To address the problems of the traditional acid leaching process and increasing demand for decarbonization, a technique for the selective carbonation leaching of Li and the recovery of battery‐grade Li2CO3 by a simple concentration precipitation process without acids or bases was developed. The coupling of CO2 and reducing agents could effectively promote the precipitation of MCO3 (M=Ni/Co/Mn) and the selective leaching of Li by decreasing the reducing capability needed for transition metals and decreasing the pH of the solution. The optimal selective leaching process of Li was obtained under 1 MPa CO2 with 20 g/L Na2S2O3 at an L/S ratio of 30 mL/g for 1.5 h. FT‐IR, XRD, ICP‐MS and other methods were used to reveal the multiphase interfacial reaction mechanism of the carbonation reduction of layered cathode materials, which indicated that the reducing agent Na2S2O3 could promote lattice distortion of the cathode materials and effective separation of Li. In summary, a green and economical method for the selective recovery of battery‐grade Li2CO3 using a one‐step method of CO2 carbonation recovery in a near‐neutral environment was proposed.
Embracing the impact from instrumented mouthguards (iMGs): A survey of iMG managers' perceptions of staff and player interest into the technology, data and barriers to use
Authors: Roe Gregory , Whitehead Sarah , Starling Lindsay , Allan David , Cross Matt , Falvey Éanna , Kemp Simon , Owen Cameron , Readhead Clint , Salmon Danielle , Scantlebury Sean , Stokes Keith , Tierney Greg , Tooby James , Tucker Ross , Jones Ben 
Published: March 2024

AbstractInstrumented mouthguards (iMGs) are a novel technology being used within rugby to quantify head acceleration events. Understanding practitioners' perceptions of the barriers and facilitators to their use is important to support implementation and adoption. This study assessed men's and women's rugby union and league iMG managers' perceptions of staff and player interest in the technology, data and barriers to use. Forty‐six iMG managers (men's rugby union and league n = 20 and n = 9 and women's rugby union and league n = 7 and n = 10) completed an 18‐question survey. Perceived interest in data varied across staff roles with medical staff being reported as having the most interest. The iMG devices were perceived as easy to use but uncomfortable. Several uses of data were identified, including medical applications, player monitoring and player welfare. The comfort, size and fit of the iMG were reported as the major barriers to player use. Time constraints and a lack of understanding of data were barriers to engagement with the data. Continued education on how iMG data can be used is required to increase player and staff buy‐in, alongside improving comfort of the devices. Studies undertaken with iMGs investigating player performance and welfare outcomes will make data more useful and increase engagement.
Innovative multiobjective optimization of a curved‐blade vertical axis wind turbine modeled by modified double multiple streamtube method
Authors: Sanaye Sepehr , Hosseinkhani Abolfazl 
Published: March 2024

AbstractThe attractive specifications of vertical axis wind turbine (VAWT) are its operating with low noise and wind in various directions. To achieve a higher performance of these turbines, modeling of a curved‐blade VAWT by the modified double multiple streamtube (DMST) method and optimizing this wind turbine are performed. The power coefficient and the total normal force acting on blades were selected as two objective functions. Minimizing the normal force acting on turbine blades as the second objective function was not observed in the open literature. The amount of normal force is crucial in the structural design of VAWT because it generates both the bending moment on blades and forces on supporting arms of VAWT. Another innovation of this study is to consider the shape coefficient parameter that determines the shape of the rotor geometry as a design variable in optimization procedure. A 3 m height curved‐blade VAWT type was optimized by this multi‐objective optimization technique. The optimum values of the design variables obtained by the Genetic Algorithm were selecting an elliptical rotor geometry, pitch angle −1.4°, diameter/height 1.3, blade aspect ratio 19.8, tip speed ratio 4.3 and selecting three blades which could provide a power coefficient of 0.49 and a normal force of 158.7 N.
Effect of freeze–thaw cycles on membrane electrode assembly of proton exchange membrane fuel cells and its fault diagnosis method
Authors: Zhang Ruixuan , Chen Tao , Zhang Rufeng , Gan Zhongyu 
Published: March 2024

AbstractIn low‐temperature environment, the residual water in the membrane electrode assembly (MEA) will freeze after the operation of proton exchange membrane fuel cells, which will cause damage to the MEA. In this paper, the effect of freeze–thaw cycles on MEA was studied. Six sets of MEA samples with 0, 20, 40, 60, 80, and 100 times freeze–thaw cycles were set up, and the damage on MEAs is analyzed by polarization curves, electrochemical impedance spectra, cyclic voltammetry curves, and scanning electron microscope. It was found that the freeze–thaw cycles caused degradation on MEA, and the ohmic resistance of MEA increases with the number of cycles increases before the 60 freeze–thaw cycles, and after 60 freeze–thaw cycles, a gap appeared between the proton exchange membrane (PEM) and the catalyst layer, which led to more water entering the PEM and the ohmic resistance of MEA decreased. Besides, according to the data analysis, the experimental samples are divided into three categories (normal MEA, lightly damaged MEA, and seriously damaged MEA). A classifier model combining inception network and light gradient boosting machine (LGBM) was established, and it was found that the combined model was better than inception–dense and LGBM for classification, reaching 96.89%.