bluuebunny/crossref_metadata_2025_split huggingface dataset:
Techno-Economic Analysis of Using Reversible Turbomachinery for Pumped Thermal Energy Storage Systems
Authors: Parisi Simone , Desai Nishith B. , Haglind Fredrik 
Published: March 2024

Abstract
The objective of this paper is to assess the techno-economic performance of different cycle configurations for pumped thermal energy storage (PTES), including the effects of charging electricity costs. Reversible turbomachinery was employed to reduce the capital cost of the system. Brayton cycles with different working fluids and a subcritical Rankine cycle operating with ammonia were compared. Both liquid and packed bed thermal storages were investigated. A new cost correlation for turbomachines, initially established for the turbines of organic Rankine cycles, was developed for compressors and reversible machines. This correlation is based on the number of stages and physical size of the machine, which were estimated considering thermodynamic as well as mechanical limitations. The results indicate that for a plant size of 50 MW and a discharge duration of 8 h, the Brayton system with liquid storage and helium as a working fluid has the lowest levelized cost of storage at 0.138 $/kWh, mainly due to the high thermal conductivity of the fluid. Packed bed thermal energy storage systems were found to be more expensive than liquid storage systems due to the large cost of the pressure vessels, with cost parity reached at a discharge duration of 4 h. However, at this duration, lithium-ion batteries are likely to be cheaper. The results suggest that the levelized cost of storage for the Rankine cycle-based system is slightly higher at 0.151 $/kWh.
Complete genome sequence of
Mycobacterium smegmatis
phage Rummer, a subcluster A3 actinophage
Authors: Bailey Dondra S. , Dotson Dominique R. , Berkes Charlotte , Agbede Oluwanifemi , Augustin Marcelaine , Blackman-Murray Imani , Chambers Talaeya , Felber Nicolas , Fleming Dy'Mon , Frazier Loretta , Gray Natalie , Harrison Ayanna , Hernandez Genesis , Iwuchukwu Nina , Iwuji Chika , Jackson Taysha , Jefferson Angelic , Jordan Daya , Jordan Miracle , Nicolas Brian , Person Monae , Richardson Ga'Nayah , Roman Ashley , Stevens Christian , Suggs My'Sean , Thompson Nahshon , Timmons-Smith Summer , Wilfong Shiaishea , Wilson-Wheatley Micaela 
Published: March 2024

ABSTRACT

Bacteriophage Rummer is a siphovirus morphology actinophage isolated from
Mycobacterium smegmatis
. Rummer has a 50,908 base pair genome encoding 89 predicted protein-coding genes and three tRNAs. Based on gene content similarity to sequenced actinobacteriophages, Rummer is assigned to phage subcluster A3.
Draft genome sequences of two β-glucuronidase positive strains of
Salmonella enterica
subspecies
salamae
isolated from reptile feces in KwaZulu-Natal, South Africa
Authors: Claussen Maike , Schmidt Stefan 
Published: March 2024

ABSTRACT

Two
Salmonella enterica
isolates obtained from reptile feces displayed β-glucuronidase activity. Nearly complete genome sequences were obtained after shotgun sequencing and
de novo
genome assembly. By comparison to reference genomes, both isolates were identified as
Salmonella enterica
subspecies
salamae
with the sequence type identified as 1208 and the serotype as 42:r:-.
Landscape of IGH germline genes of Chiroptera and the pattern of
Rhinolophus affinis
bat IGH CDR3 repertoire
Authors: Ma Long , Liu Longyu , Li Jun , Zhou Hao , Xiao Jiaping , Ma Qingqing , Yao Xinsheng 
Published: March 2024

ABSTRACT

The emergence and re-emergence of abundant viruses from bats that impact human and animal health have resulted in a resurgence of interest in bat immunology. Characterizing the immune receptor repertoire is critical to understanding how bats coexist with viruses in the absence of disease and developing new therapeutics to target viruses in humans and susceptible livestock. In this study, IGH germline genes of Chiroptera including
Rhinolophus ferrumequinum
,
Phyllostomus discolor,
and
Pipistrellus pipistrellus
were annotated, and we profiled the characteristics of
Rhinolophus affinis
(RA) IGH CDR3 repertoire. The germline genes of Chiroptera are quite different from those of human, mouse, cow, and dog in evolution, but the three bat species have high homology. The CDR3 repertoire of RA is unique in many aspects including CDR3 subclass, V/J genes access and pairing, CDR3 clones, and somatic high-frequency mutation compared with that of human and mouse, which is an important point in understanding the asymptomatic nature of viral infection in bats. This study unveiled a detailed map of bat IGH germline genes on chromosome level and provided the first immune receptor repertoire of bat, which will stimulate new avenues of research that are directly relevant to human health and disease.

IMPORTANCE
The intricate relationship between bats and viruses has been a subject of study since the mid-20th century, with more than 100 viruses identified, including those affecting humans. While preliminary investigations have outlined the innate immune responses of bats, the role of adaptive immunity remains unclear. This study presents a pioneering contribution to bat immunology by unveiling, for the first time, a detailed map of bat IGH germline genes at the chromosome level. This breakthrough not only provides a foundation for B cell receptor research in bats but also contributes to primer design and sequencing of the CDR3 repertoire. Additionally, we offer the first comprehensive immune receptor repertoire of bats, serving as a crucial library for future comparative analyses. In summary, this research significantly advances the understanding of bats’ immune responses, providing essential resources for further investigations into viral tolerance and potential zoonotic threats.
Comprehensive seismic evidence for the inducing mechanism of extremely shallow 2019 Changning Ms 6.0 earthquake by solution salt mining, Sichuan Basin, China
Authors: Anyiam Uzonna Okenna , Qian Jiawei , Tan Yuyang , Zhang Haijiang 
Published: March 2024

Abstract
In the Changning region of the Sichuan Basin, China, which has experienced decades-long injection of freshwater for commercial salt mining, a Ms 6.0 earthquake occurred in June 2019, along with four Ms &gt;5 aftershocks. Using data from local and regional seismic stations, we determine accurate locations for this earthquake sequence, velocity structures, and excess pore fluid pressures of the source region. Our results show that the Ms 6.0 earthquake is extremely shallow (~1.6 km below mean sea level) and is associated with low Vs and high Vp/Vs values and excess fluid pressures, indicating a fluid-induced earthquake. The mainshock was likely the shallowest M &gt;6.0 induced earthquake, and it was triggered by the combined effect of pore pressure increase from the diffusion of injected fluids, differential formation subsidence from salt caverns, and highly fractured slip-prone rocks enriched in quartz and silica content. Following Coulomb stress transfer from the mainshock, the sequence ruptured in a cascading manner involving preexisting oblique faults of varying dips.
Tumor-Infiltrating Lymphocytes Refine Outcomes in Triple-Negative Breast Cancer Treated with Anthracycline-Free Neoadjuvant Chemotherapy
Authors: Martín Miguel , Yoder Rachel , Salgado Roberto , del Monte-Millán María , Álvarez Enrique L. , Echavarría Isabel , Staley Joshua M. , O'Dea Anne P. , Nye Lauren E. , Stecklein Shane R. , Bueno Coralia , Jerez Yolanda , Cebollero María , Bueno Oscar , García Saenz José Ángel , Moreno Fernando , Bohn Uriel , Gómez Henry , Massarrah Tatiana , Khan Qamar J. , Godwin Andrew K. , López-Tarruella Sara , Sharma Priyanka 
Published: March 2024

Abstract

Purpose:
Stromal tumor-infiltrating lymphocytes (sTIL) are associated with pathologic complete response (pCR) and long-term outcomes for triple-negative breast cancer (TNBC) in the setting of anthracycline-based chemotherapy. The impact of sTILs on refining outcomes beyond prognostic information provided by pCR in anthracycline-free neoadjuvant chemotherapy (NAC) is not known.

Experimental Design:
This is a pooled analysis of two studies where patients with stage I (T&gt;1 cm)–III TNBC received carboplatin (AUC 6) plus docetaxel (75 mg/m2; CbD) NAC. sTILs were evaluated centrally on pre-treatment hematoxylin and eosin slides using standard criteria. Cox regression analysis was used to examine the effect of variables on event-free survival (EFS) and overall survival (OS).

Results:
Among 474 patients, 44% had node-positive disease. Median sTILs were 5% (range, 1%–95%), and 32% of patients had ≥30% sTILs. pCR rate was 51%. On multivariable analysis, T stage (OR, 2.08; P = 0.007), nodal status (OR, 1.64; P = 0.035), and sTILs (OR, 1.10; P = 0.011) were associated with pCR. On multivariate analysis, nodal status (HR, 0.46; P = 0.008), pCR (HR, 0.20; P &lt; 0.001), and sTILs (HR, 0.95; P = 0.049) were associated with OS. At 30% cut-point, sTILs stratified outcomes in stage III disease, with 5-year OS 86% versus 57% in ≥30% versus &lt;30% sTILs (HR, 0.29; P = 0.014), and numeric trend in stage II, with 5-year OS 93% versus 89% in ≥30% versus &lt;30% sTILs (HR, 0.55; P = 0.179). Among stage II–III patients with pCR, EFS was better in those with ≥30% sTILs (HR, 0.16; P, 0.047).

Conclusions:
sTILs density was an independent predictor of OS beyond clinicopathologic features and pathologic response in patients with TNBC treated with anthracycline-free CbD chemotherapy. Notably, sTILs density stratified outcomes beyond tumor–node–metastasis (TNM) stage and pathologic response. These findings highlight the role of sTILs in patient selection and stratification for neo/adjuvant escalation and de-escalation strategies.
Intravenous Alteplase Versus Best Medical Therapy for Patients With Minor Stroke: A Systematic Review and Meta-Analysis
Authors: Zhang Yang , Lv Tian , Nguyen Thanh N. , Wu Simiao , Li Zhi , Bai Xue , Chen Dan , Zhao Chuansheng , Lin Wanyi , Chen Shiqin , Sui Yi 
Published: March 2024

BACKGROUND:
The efficacy of thrombolysis (IVT) in minor stroke (National Institutes of Health Stroke Scale score, 0–5) remains inconclusive. The aim of this study is to compare the effectiveness and safety of IVT with best medical therapy (BMT) by means of a systematic review and meta-analysis of randomized controlled trials and observational studies.

METHODS:
We searched the PubMed, Embase, Cochrane Library, and Web of Science databases to obtain articles related to IVT in minor stroke from inception until August 10, 2023. The primary outcome was an excellent functional outcome, defined as a modified Rankin Scale score of 0 or 1 at 90 days. The associations were calculated for the overall and preformulated subgroups by using the odds ratios (ORs). This study was registered with PROSPERO (CRD42023445856).

RESULTS:
A total of 20 high-quality studies, comprised of 13 397 patients with acute minor ischemic stroke, were included. There were no significant differences observed in the modified Rankin Scale scores of 0 to 1 (OR, 1.10 [95% CI, 0.89–1.37]) and 0 to 2 (OR, 1.16 [95% CI, 0.95–1.43]), mortality rates (OR, 0.67 [95% CI, 0.39–1.15]), recurrent stroke (OR, 0.89 [95% CI, 0.57–1.38]), and recurrent ischemic stroke (OR, 1.09 [95% CI, 0.68–1.73]) between the IVT and BMT group. There were differences between the IVT group and the BMT group in terms of early neurological deterioration (OR, 1.81 [95% CI, 1.17–2.80]), symptomatic intracranial hemorrhage (OR, 7.48 [95% CI, 3.55–15.76]), and hemorrhagic transformation (OR, 4.73 [95% CI, 2.40–9.34]). Comparison of modified Rankin Scale score of 0 to 1 remained unchanged in subgroup patients with nondisabling deficits or compared with those using antiplatelets.

CONCLUSIONS:
These findings indicate that IVT does not yield significant improvement in the functional prognosis of patients with acute minor ischemic stroke. Additionally, it is associated with an increased risk of symptomatic intracranial hemorrhage when compared with the BMT. Moreover, IVT may not have superiority over BMT in patients with nondisabling deficits or those using antiplatelets.
Relationship of Perivascular Space Markers With Incident Dementia in Cerebral Small Vessel Disease
Authors: Hong Hui , Tozer Daniel J. , Markus Hugh S. 
Published: March 2024

BACKGROUND:
Recent studies, using diffusion tensor image analysis along the perivascular space (DTI-ALPS), suggest impaired perivascular space (PVS) function in cerebral small vessel disease, but they were cross-sectional, making inferences on causality difficult. We determined associations between impaired PVS, measured using DTI-ALPS and PVS volume, and cognition and incident dementia.

METHODS:
In patients with lacunar stroke and confluent white matter hyperintensities, without dementia at baseline, recruited prospectively in a single center, magnetic resonance imaging was performed annually for 3 years, and cognitive assessments, including global, memory, executive function, and processing speed, were performed annually for 5 years. We determined associations between DTI-ALPS and PVS volume with cerebral small vessel disease imaging markers (white matter hyperintensity volume, lacunes, and microbleeds) at baseline and with changes in imaging markers. We determined whether DTI-ALPS and PVS volume at baseline and change over 3 years predicted incident dementia. Analyses were controlled for conventional diffusion tensor image metrics using 2 markers (median mean diffusivity [MD] and peak width of skeletonized MD) and adjusted for age, sex, and vascular risk factors.

RESULTS:

A total of 120 patients, mean age 70.0 years and 65.0% male, were included. DTI-ALPS declined over 3 years, while no change in PVS volume was found. Neither DTI-ALPS nor PVS volume was associated with cerebral small vessel disease imaging marker progression. Baseline DTI-ALPS was associated with changes in global cognition (β=0.142,
P
=0.032), executive function (β=0.287,
P
=0.027), and long-term memory (β=0.228,
P
=0.027). Higher DTI-ALPS at baseline predicted a lower risk of dementia (hazard ratio, 0.328 [0.183–0.588];
P
<0.001), and this remained significant after including median MD as a covariate (hazard ratio, 0.290 [0.139–0.602];
P
<0.001). Change in DTI-ALPS predicted dementia conversion (hazard ratio, 0.630 [0.428–0.964];
P
=0.048), but when peak width of skeletonized MD and median MD were entered as covariates, the association was not significant. There was no association between baseline PVS volume, or PVS change over 3 years, and conversion to dementia.

CONCLUSIONS:
DTI-ALPS predicts future dementia risk in patients with lacunar strokes and confluent white matter hyperintensities. However, the weakening of the association between change in DTI-ALPS and incident dementia after controlling for peak width of skeletonized MD and median MD suggests part of the signal may represent conventional diffusion tensor image metrics. PVS volume is not a predictor of future dementia risk.
Price Mechanism, Government Constraints and Carbon Trading Pilot Policy for Emission Reduction
Authors: Wei Huang , Haili Xue , Qin Zhang , Xiao Lan , Haoguang Liang 
Published: March 2024

ABSTRACT
Based on the data of 247 cities at the prefecture level in China from 2007 to 2019, this paper analyzes the impact of the carbon emissions trading CET pilot policy on carbon emission reduction from the perspective of the price mechanism and government constraints. The results show that the carbon emissions and carbon intensity in the pilot areas are significantly reduced by adjusting the industrial structure and promoting green technology innovation. In terms of regions, the emission reduction effect of the pilot policy in regions with a high proportion of industry is obviously weaker than that in other regions. The aim of the carbon emission trading policy in China that achieve carbon emission reduction is by coordinating the carbon emission trading price that fail to fulfill this aim independently and the degree of government punishment for enterprises.
Exploring Human-Like Translation Strategy with Large Language
Models
Authors: He Zhiwei , Liang Tian , Jiao Wenxiang , Zhang Zhuosheng , Yang Yujiu , Wang Rui , Tu Zhaopeng , Shi Shuming , Wang Xing 
Published: March 2024

Abstract
Large language models (LLMs) have demonstrated impressive capabilities in general scenarios, exhibiting a level of aptitude that approaches, in some aspects even surpasses, human-level intelligence. Among their numerous skills, the translation abilities of LLMs have received considerable attention. Compared to typical machine translation that focuses solely on source-to-target mapping, LLM-based translation can potentially mimic the human translation process, which might take preparatory steps to ensure high-quality translation. This work explores this possibility by proposing the MAPS framework, which stands for Multi-Aspect Prompting and Selection. Specifically, we enable LLMs first to analyze the given source sentence and induce three aspects of translation-related knowledge (keywords, topics, and relevant demonstrations) to guide the final translation process. Moreover, we employ a selection mechanism based on quality estimation to filter out noisy and unhelpful knowledge. Both automatic (3 LLMs × 11 directions × 2 automatic metrics) and human evaluation (preference study and MQM) demonstrate the effectiveness of MAPS. Further analysis shows that by mimicking the human translation process, MAPS reduces various translation errors such as hallucination, ambiguity, mistranslation, awkward style, untranslated text, and omission. Source code is available at https://github.com/zwhe99/MAPS-mt.
The Unthought of Modernity
Authors: Delport Khegan M. 
Published: March 2024

Abstract
The modernity of the West has generally tended to construct the relation between magic and religion according to a developmentalist schema, chiefly as a movement from the primitive to the modern, from superstition to enlightenment. However, recent developments in the study of religion, intellectual history, critical theory, as well as theology demonstrate that such a dualism might be unsustainable. The persistence of the magical into the discourses of modernity (e.g., science, philosophy, and theology) undermines any framing narrative of this sort. In this essay, which serves as an introduction to a special section in Religion & Theology on magic, science, philosophy, and theology, I put forward both a descriptive and constructive account as to why the construct of “magic,” in the words of Randall Styers, may be considered “the unthought of modernity.”
The Frontispiece as Patron’s Statement
Authors: Ritter Markus 
Published: March 2024

Abstract
The Rasāʾil Ikhwān al-ṣafāʾ wa-khullān al-wafāʾ (Epistles of the Brethren of Purity and Loyal Friends), copied in Baghdad in 686/1287 and kept in the Süleymaniye Library in Istanbul, is known for its double page frontispiece, headed by the names of the authors and the book title, and painted with an image of debating scholars surrounded by luxurious architecture [Fig. 1]. The copy features diagrams and tables and is of interest for the study of medieval manuscript traditions of the Rasāʾil. This article re-examines the codex, expanding observations and insights into its history. It discusses the function of the frontispiece, which has been perceived as an authors’ portrait in the succession of pre-Mongol Arab book painting, but is unique among known Rasāʾil copies. Reviewing the text on the double page and considering that the Rasāʾil was an anonymous book, we argue that the frontispiece advertised a particular opinion and reference regarding the authorship, visualized and emphasised through the medium of the figural image. Situating the copy in the scholarly book production of early Ilkhanid Baghdad under the Persian Juwaynī governors from early Ilkhanid Iran, the article examines how that time and place are referenced in the painting. Extending the question to the unknown patron and his milieu, it discusses figures with portrait-like faces presenting a book as possible references to the Juwaynīs. We suggest to see the novelty of the painting not only in its style and close text-image relation, but in its function as editorial statement and in the layered references. These evidence a concept of visual commentary on both history and present, that has been argued for Ilkhanid painting of northwest Iran, but was used here several decades earlier in Baghdad.
Do 3–8 Years Old Children Benefit From Computational Thinking Development? A Meta-Analysis
Authors: Wang Xiaowen , Chan Kan Kan , Li Qianru , Leung Shing On 
Published: March 2024

The interest in Computational Thinking (CT) development among young learners increases with the number of studies located in literature. In this study, a meta-analysis was conducted to address two main objectives: (a) the effectiveness of empirical interventions on the development of CT in children aged of 3–8 years; and (b) the variables that influence the effectiveness of the interventions. Following PRISMA procedures, we identified 17 empirical studies with 34 effect sizes and 1665 participants meeting the inclusion criteria from Web of Science database. Overall, we found a statistically significant large effect size (d = .83 [95% CI: 730, .890]; p < .001) on the CT development of 3–8 years old children, which provides empirical support for having young children to engage in CT experiences. The effect size was significantly influenced by moderating variables including gender, scaffolding, and education level. Intervention length showed a marginally significant effect. Therefore, educators could refer to the significant moderators when designing tailored interventions for CT development in early childhood education while a call for more empirical studies of CT development in young children is proposed.
Structured, Creative Dance Classes for Children with Developmental Disabilities: A Pilot Study of Feasibility and Preliminary Effect on Motor Function
Authors: Kempner Kelsey , Dixon Melanye White , Failla Michelle D. , Hadley Susan , Worthen-Chaudhari Lise 
Published: March 2024

Introduction: Promoting physical wellness for preschool-aged children with developmental disorders (DD) is a known challenge. Interventions are more likely to succeed when physical activity opportunities are available to children within the context of their typical environments. We evaluated the feasibility and preliminary effect of 1 potential solution: structured creative dance classes delivered within a preschool environment. Methods: Using a non-randomized feasibility study design, we offered physical activity in the form of creative dance classes for children with and without DD within an inclusive preschool. Classes lasted 30 minutes and were held once a week or 7 weeks. We measured attendance (primary), observed active participation (% of class duration), and balance (Pediatric Balance Scale). Non-parametric descriptive statistics are expressed as median (interquartile range). Balance was evaluated regarding (a) difference between groups at baseline (Mann-Whitney statistic) and (b) intervention effect for children with DD (1-tailed, paired t-test). Results: Twelve preschoolers (age range = 3-5 years) participated: 4 with DD and 8 with neurotypical development. Attendance was 93% (79%-100%) for children with and 100% for children without DD. Per class, rate of active participation in dance activity was 33% (28%-45%) for children with and 80% (71%-82%) for children without DD. Starting balance scores were lower ( P = .014) for children with DD (42 (39-45)) compared to those without (51 (50-52)). Post-intervention, balance scores improved for the children with DD to 50 (50-51) (df = 3, p = .014, t-statistic = 2.35); each child with DD surpassed minimal detectable change for balance. Conclusion: Creative dance classes, delivered within an inclusive preschool environment, are feasible for some preschool-aged children with DD to participate in and efficacious as a physical training challenge at low activity doses. More study is warranted of this potential solution to meet the need for physical wellness promotion among young children with DD.