bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tooth wear and dental pathology at the advent of agriculture: New evidence from the Levant
Authors: Eshed Vered , Gopher Avi , Hershkovitz Israel 
Published: December 2005

AbstractDifferences in patterns of diet and subsistence through the analysis of dental pathology and tooth wear were studied in skeletal populations of Natufian hunter‐gatherers (10,500–8300 BC) and Neolithic populations (8300–5500 BC, noncalibrated) from the southern Levant. 1,160 Natufians and 804 Neolithic teeth were examined for rate of attrition, caries, antemortem tooth loss, calculus, periapical lesions, and periodontal processes. While the Natufian people manifest a higher rate of dental attrition and periodontal disease (36.4% vs. 19%), Neolithic people show a higher rate of calculus. Both populations manifested low and similar rates of caries (6.4% in the Natufian vs. 6.7% in the Neolithic), periapical lesions (not over 1.5%), and antemortem tooth loss (3.7% vs. 4.5%, respectively). Molar wear pattern in the Neolithic is different than in the Natufian. The current study shows that the dental picture obtained from the two populations is multifactorial in nature, and not exclusively of dietary origin, i.e., the higher rate and unique pattern of attrition seen in the Natufian could result from a greater consumption of fibrous plants, the use of pestles and mortars (which introduce large quantities of stone‐dust to the food), and/or the use of teeth as a “third hand.” The two major conclusions of this study are: 1) The transition from hunting and gathering to a food‐producing economy in the Levant did not promote changes in dental health, as previously believed. This generally indicates that the Natufians and Neolithic people of the Levant may have differed in their ecosystem management (i.e., gathering vs. growing grains), but not in the type of food consumed. 2) Changes in food‐preparation techniques and nondietary usage of the teeth explain much of the variation in tooth condition in populations before and after the agricultural revolution. Am J Phys Anthropol, 2006. © 2005 Wiley‐Liss, Inc.
Low‐Temperature Activation and Deactivation of High‐Curie‐Temperature Ferromagnetism in a New Diluted Magnetic Semiconductor: Ni2+‐Doped SnO2.
Authors: Archer Paul I. , Radovanovic Pavle V. , Heald Steve M. , Gamelin Daniel R. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Preparation and Characterization of Powders and Crystals of Vn‐xTixO2n‐1 Magneli Oxides.
Authors: Calestani D. , Licci F. , Kopnin E. , Calestani G. , Gauzzi A. , Bolzoni F. , Besagni T. , Boffa V. , Marezio M. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Germanate Framework Containing 24‐Ring Channels, Ni—Ge Bonds, and Chiral [Ni@Ge14O24(OH)3] Cluster Motifs Transferred from Chiral Metal Complexes.
Authors: Lin Zhi‐En , Zhang Jie , Zhao Jing‐Tai , Zheng Shou‐Tian , Pan Chun‐Yang , Wang Guo‐Ming , Yang Guo‐Yu 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Catalytic Investigations of Carbon—Carbon Bond‐Forming Reactions by a Hydroxyapatite‐Bound Palladium Complex.
Authors: Mori Kohsuke , Hara Takayoshi , Oshiba Michitaka , Mizugaki Tomoo , Ebitani Kohki , Kaneda Kiyotomi 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Heavily Substituted 1,2‐Amino Alcohols in Enantiomerically Pure Form.
Authors: Garcia‐Delgado Noemi , Reddy Katamreddy Subba , Sola Lluis , Riera Antoni , Pericas Miquel A. , Verdaguer Xavier 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 5‐Substituted 4‐Aminoalkylpyrazol‐3‐ones (Isoxazol‐3‐ones) from 3‐Acyllactams.
Authors: Nenajdenko V. G. , Zakurdaev E. P. , Gololobov A. M. , Balenkova E. S. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Some 3‐Phenyl‐4‐methyl‐6‐(6‐styryl‐4‐arylpyridin‐2‐yl)‐, 6‐(4‐Styryl‐6‐arylpyridin‐2‐yl)‐ and 6‐(4‐Aryl‐8‐aryledine‐5,6,7,8‐tetrahydroquinolin‐2‐yl)coumarins
Authors: Brahmbhatt D. I. , Pandya V. P. , Patel C. N. , Patel M. A. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Condensed Tetrazolo‐1,3,5‐triazines. Part 1. Synthesis of 5‐Polynitromethyltetrazolo[1,5‐a]‐1,3,5‐triazin‐7‐one Salts.
Authors: Fedorov B. S. , Fadeev M. A. , Gidaspov A. A. , Kosareva E. A. , Bakharev V. V. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
First Synthesis of α‐Aminophosphonates from Natural Porphyrin Derivatives by the Kabachnik—Fields Reaction
Authors: Kabachnic M. M. , Zobnina E. V. , Pavlov V. Yu. , Konstantinov I. O. , Ponomarev G. V. , Beletskaya I. P. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
The Novel Gluconeogenesis Inhibitor FR225654 that Originates from Phoma sp. No. 00144. Part 1. Taxonomy, Fermentation, Isolation and Physico‐Chemical Properties.
Authors: Ohtsu Yoshihiro , Sasamura Hiromi , Tanaka Miho , Tsurumi Yasuhisa , Yoshimura Seiji , Takase Shigehiro , Shibata Toshihiro , Hino Motohiro , Nakajima Hidenori 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Novel Synthesis of Nanosized Cellular Iron Oxide/Oxyhydroxide Thin Films. Part 1. Electrochemical Synthesis of Green Rust Thin Films and Their Chemical Oxidation.
Authors: Chung Kyeong Woo , Kim Kwang Bum , Han Seong‐Ho , Lee Hongkee 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Hydrophilic and Hydrophobic Pd Nanoparticles with in situ Generated Reducing Agent and Their Application as Activator for Electroless Copper and Nickel Depositions.
Authors: Lee Chien‐Liang , Huang Yu‐Ching , Wan Chi‐Chao , Wang Yun‐Yung , Ju Yu‐Jen , Kuo Li‐Chen , Oung Jung‐Chou 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Monoliths as Biocatalytic Reactors: Smart Gas—Liquid Contacting for Process Intensification
Authors: Kreutzer Michiel T. , Kapteijn Freek , Moulijn Jacob A. , Ebrahimi Sirous , Kleerebezem Robbert , van Loosdrecht Mark C. M. 
Published: December 2005

AbstractFor Abstract see ChemInform Abstract in Full Text.
Hybrid‐mixed stress formulation using continuum damage models
Authors: Silva C. M. , Castro L. M. S. S. 
Published: December 2005

AbstractThis paper reports on the non‐linear static analysis of 2D concrete structures using an hybrid‐mixed stress formulation and continuum damage mechanics. The finite element model adopted is based on the direct and independent approximation of three fields: the effective stress and displacement fields in the domain of each element and the displacement field on the static boundary. The non‐linear behaviour of the material is modelled with a non‐local isotropic damage model. A set of numerical examples are presented to illustrate and validate the use of such numerical technique. The performance of the model is assessed by comparison with results obtained using other numerical schemes presented in the literature and also with experimental results. Copyright © 2005 John Wiley & Sons, Ltd.
Taverna: lessons in creating a workflow environment for the life sciences
Authors: Oinn Tom , Greenwood Mark , Addis Matthew , Alpdemir M. Nedim , Ferris Justin , Glover Kevin , Goble Carole , Goderis Antoon , Hull Duncan , Marvin Darren , Li Peter , Lord Phillip , Pocock Matthew R. , Senger Martin , Stevens Robert , Wipat Anil , Wroe Chris 
Published: December 2005

AbstractLife sciences research is based on individuals, often with diverse skills, assembled into research groups. These groups use their specialist expertise to address scientific problems. The in silico experiments undertaken by these research groups can be represented as workflows involving the co‐ordinated use of analysis programs and information repositories that may be globally distributed. With regards to Grid computing, the requirements relate to the sharing of analysis and information resources rather than sharing computational power. The myGrid project has developed the Taverna Workbench for the composition and execution of workflows for the life sciences community. This experience paper describes lessons learnt during the development of Taverna. A common theme is the importance of understanding how workflows fit into the scientists' experimental context. The lessons reflect an evolving understanding of life scientists' requirements on a workflow environment, which is relevant to other areas of data intensive and exploratory science. Copyright © 2005 John Wiley & Sons, Ltd.
Scientific workflow management and the Kepler system
Authors: Ludäscher Bertram , Altintas Ilkay , Berkley Chad , Higgins Dan , Jaeger Efrat , Jones Matthew , Lee Edward A. , Tao Jing , Zhao Yang 
Published: December 2005

AbstractMany scientific disciplines are now data and information driven, and new scientific knowledge is often gained by scientists putting together data analysis and knowledge discovery ‘pipelines’. A related trend is that more and more scientific communities realize the benefits of sharing their data and computational services, and are thus contributing to a distributed data and computational community infrastructure (a.k.a. ‘the Grid’). However, this infrastructure is only a means to an end and ideally scientists should not be too concerned with its existence. The goal is for scientists to focus on development and use of what we callscientific workflows. These are networks of analytical steps that may involve, e.g., database access and querying steps, data analysis and mining steps, and many other steps including computationally intensive jobs on high‐performance cluster computers. In this paper we describe characteristics of and requirements for scientific workflows as identified in a number of our application projects. We then elaborate on Kepler, a particular scientific workflow system, currently under development across a number of scientific data management projects. We describe some key features of Kepler and its underlying Ptolemy II system, planned extensions, and areas of future research. Kepler is a community‐driven, open source project, and we always welcome related projects and new contributors to join. Copyright © 2005 John Wiley & Sons, Ltd.
Enumeration of peripheral lymphocyte subsets using 6 vs. 4 color staining: A clinical evaluation of a new flowcytometer
Authors: Lambert Claude , Cristina Iobagiu , Christian Genin 
Published: December 2005

AbstractTechnological advances in instruments allow the evaluation of many lymphocyte subsets in one step. The aim of this study was to evaluate the new FACSCanto flowcytometer in routine conditions, using a 6 color combination, single platform, whole blood, lysis, no wash protocol.MethodsTwo systems were simultaneously compared on 67 blood samples and external quality controls, using CD3,CD4, CD8, CD19, CD16/56, and CD45 in one tube TRUCOUNT beads™ (BD Biosciences) or two tubes (TetraChrome™ and Flowcount™, Beckman‐Coulter and DakoCytomation).ResultsThe day‐to‐day instrument detection but automatic compensations were stable. Manual compensation settings were satisfactory using available facilities. Commercial and UK NEQAS quality control results were acceptable. The intra‐experiment reproducibility was good (coefficient of variation (CV) <3%) but highly operator‐dependant (CD4+ T cell count CVs from 1.2 to 9.7, six operators). Storage of samples was acceptable, but storage of stained samples altered absolute count reliability. Serial dilutions show a good count accuracy. The FACScanto T subsets and B cell data were highly correlated with our reference values (r2 > 0.87) and absolutes values were very close (slopes > 0.89).The gating strategy, fluorochrome choice, and compensation setting are discussed. A few improvements are expected (sample loader, data management, auto‐gating, acquisition parameters, sample mixing, absolute values calculation, etc).In conclusions, despite its complexity, 6 color staining is a reliable, stable, and highly informative technique for lymphocyte subset monitoring but remains to be optimized. © 2005 Wiley‐Liss, Inc.
Report on the second Latin American consensus conference for flow cytometric immunophenotyping of hematological malignancies
Authors: Ruiz‐Argüelles Alejandro , Rivadeneyra‐Espinoza Liliana , Duque Ricardo E. , Orfao Alberto 
Published: December 2005

AbstractOn May 3 and 4, 2005, the Second Latin American Consensus Conference for the Immunophenotyping of Hematological Malignancies took place in Queretaro, México, with representatives from 10 countries of the region and two external consultants. This document summarizes the major conclusions for which consensus were achieved. Major differences regarding the recommendations from the first conference, which took place 9 years ago, concern the medical indications and the antibody panels for immunophenotyping. The aim of disseminating these guidelines to the international community is based on the potential interest for other countries with similar socioeconomic conditions. © 2005 Wiley‐Liss, Inc.
Synthesis and Properties of Cryptands with a Thioether Bridge and π‐Donors – Silver(I) and Copper(I)‐Complexes
Authors: Koschabek René , Gleiter Rolf , Rominger Frank 
Published: December 2005

AbstractThe syntheses of seven bridgehead diazabicycloalkanes are reported. The bridges are represented by either a thioether chain and two 3‐hexyne units (4 and 6–8), one selenoether chain and two 3‐hexyne units (5), or one dithioether chain and two 4,4′‐diethylbiphenyl units (9, 10). X‐ray investigations reveal for 4–10 the in/in conformation at the bridgehead nitrogen atoms. Reactions with CuI triflate yield the endohedral CuI complexes of 4–6. Endohedral complexes of 6, 7, and 10 were isolated with silver triflate. X‐ray investigations and spectroscopic studies on the metal complexes reveal interactions between the metal ion and the nitrogen‐, chalcogen‐, and π‐units. In addition to the bicyclic systems 4–10 we synthesized the tripodal systems 28–33 in a one‐pot reaction. In the cases of 28 and 33 we were able to isolate the corresponding AgI complexes. X‐ray studies show an interaction between the metal ion and the nitrogen atom and one double bond of each of the three adjacent phenyl rings. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
The Design and Synthesis of Bis(thiourea) Ligands and Their Application in Pd‐Catalyzed Heck and Suzuki Reactions Under Aerobic Conditions
Authors: Chen Wei , Li Rui , Han Bo , Li Bang‐Jing , Chen Ying‐Chun , Wu Yong , Ding Li‐Sheng , Yang Dan 
Published: December 2005

AbstractNew, bulky N,N‐disubstituted acyclic and cyclic bis(thiourea) ligands have been designed and synthesized. Their palladium(0) complexes are very stable and are active catalysts for Heck and Suzuki coupling reactions of aryl iodides and bromides under aerobic conditions. Good TONs and TOFs were achieved in the coupling reactions [for PhI, TONs up to 1000000 and TOFs up to 200000 (h–1); for activated aryl bromide, TONs up to 89000]. In addition, further studies were conducted to know more about the nature of these catalysts. The active catalyst was found to be the chelate complex containing the bis(thiourea) and Pd in a 1:1 ratio. However, unlike a monothiourea, further coordination can occur to give a coordinatively saturated complex when bis(thiourea) and Pd are combined in a 2:1 ratio; this complex is catalytically inactive in coupling reactions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
One‐Pot Addition/Reduction Procedure for the Synthesis of ‐Amino Alcohols from ‐Enamino Ketones
Authors: Cimarelli Cristina , Giuli Sandra , Palmieri Gianni 
Published: December 2005

Abstractγ‐Amino alcohols 3 have been synthesized by the addition of organolithium reagents to β‐enamino ketones 1 followed by one‐pot reduction with sodium triacetoxyborohydride. The method allows the stereoselective synthesis of γ‐amino alcohols in which the hydroxy group is bonded to a fully substituted carbon atom. The relative configuration of the chiral product was determined by 1H NMR spectroscopy. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Switch to full‐length of XAF1 mRNA expression in prostate cancer cells by the DNA methylation inhibitor
Authors: Fang Xiaolei , Liu Zhaoxu , Fan Yidong , Zheng Chengyun , Nilson Sten , Egevad Lars , Ekman Peter , Xu Dawei 
Published: December 2005

AbstractX‐linked inhibitor of apoptosis protein (XIAP) suppresses apoptotic cell death by binding to caspases and inhibiting their functions, while the XIAP‐associated factor1 (XAF1), a zinc finger protein, antagonizes XIAP activities, thereby promoting apoptosis. The aberrant silence of the XAF1 gene has recently been found in various types of cancer cells, which is suggested to be one of the potential mechanisms underlying survival advantages of malignant cells. In the present study, we investigated the XAF1 expression in prostate cancer cells. Compared with normal tissues where a full‐length of XAF1 mRNA is predominant, LNCaP and DU145 prostate cancer cell lines only expressed a short form of XAF1 transcripts, whereas PC3 cells exhibited a complete silence of the XAF1 gene. Inhibition of DNA methylation led to a switch to the full length of XAF1 mRNA expression in LNCaP and DU145 cells. The down‐regulation of XAF1 expression was also observed in 6/8 tumor samples derived from patients with prostate cancer. Our findings suggest that splicing alterations or downregulation of the XAF1 transcript may occur during the development of prostate cancers due to the aberrant DNA methylation. The alternative splicing of XAF1 mRNA leads to formation of a truncated XAF1 protein with 19 amino acid deletion in its zinc finger domain, which likely affects its functional interaction with XIAP, and consequently, contributes to the pathogenesis of prostate cancers by disrupting balance of the apoptosis machinery. © 2005 Wiley‐Liss, Inc.
Cytogenetic damage and genetic variants in the individuals susceptible to arsenic‐induced cancer through drinking water
Authors: Ghosh Pritha , Basu Anamika , Mahata Julie , Basu Sreemanti , Sengupta Mainak , Das Jayanta K. , Mukherjee Angshuman , Sarkar Ajoy K. , Mondal Lakshmikanta , Ray Kunal , Giri Ashok K. 
Published: December 2005

AbstractIn West Bengal, India, more than 300,000 arsenic‐exposed people are showing symptoms of arsenic toxicity, which include cancers of skin and different internal organs. Since only 15–20% of the exposed population manifest arsenic‐induced skin lesions, it is thought that genetic variation might play an important role in arsenic toxicity and carcinogenicity. A total of 422 unrelated arsenic‐exposed subjects (244 skin‐symptomatic and 178 asymptomatic) were recruited for this study. Cytogenetic damage, as measured by chromosomal aberrations in lymphocytes and micronuclei formation in oral mucosa cells, urothelial cells and binucleated lymphocytes, was studied in unexposed, skin‐symptomatic and asymptomatic individuals with similar socioeconomic status. Identification of null mutations in GSTT1 and GSTM1 genes were carried out by PCR amplification. GSTP1 SNPs, implicated in susceptibility to various cancers, were assessed by PCR‐RFLP method. Symptomatic individuals had higher level of cytogenetic damage compared to asymptomatic individuals and asymptomatic individuals had significantly higher genotoxicity than unexposed individuals. No difference in allelic variants in GSTT1 and GSTP1 was observed between these 2 groups. Incidence of GSTM1 null gene frequencies was significantly higher in the asymptomatic group. Individuals with GSTM1‐positive (at least one allele) had significantly higher risk of arsenic‐induced skin lesions (odds ratio, 1.73; 95% confidence interval, 1.24–2.22). These results show a protective role of GSTM1 null in arsenic toxicity. This study also indicates that asymptomatic individuals are sub clinically affected and are also significantly susceptible to arsenic‐induced genotoxicity. © 2005 Wiley‐Liss, Inc.
Inhibition of bone‐derived insulin‐like growth factors by a ligand‐specific antibody suppresses the growth of human multiple myeloma in the human adult bone explanted in NOD/SCID mouse
Authors: Araki Kazuhiro , Sangai Takafumi , Miyamoto Shin'ichi , Maeda Hiroyuki , Zhang Shi‐Chuan , Nakamura Michio , Ishii Genichiro , Hasebe Takahiro , Kusaka Hideaki , Akiyama Tadakazu , Tokuda Yoshimi , Nagai Kanji , Minami Hironobu , Ochiai Atsushi 
Published: December 2005

AbstractMultiple myeloma (MM) is a fatal disease that affects plasma cells. Patients with MM have 1 or more osteolytic lesions in their bone tissues, where insulin‐like growth factors (IGFs; IGF‐I and IGF‐II) are mainly stored. The role of bone‐derived IGFs in the development of MM has not been extensively studied because reliable animal models are lacking. We established an animal model using a human MM cell line, RPMI8226, in nonobese diabetic/severe‐combined immunodeficient (NOD/SCID) mice implanted with human adult bone (HAB) fragments. Treatment with an anti‐human IGF‐neutralizing monoclonal antibody, KM1468, inhibited the IGF‐I‐stimulated phosphorylation of type‐I IGF receptors (IGF‐IR) in RPMI8226 cells and the activation of the downstream PI3‐K/Akt signaling pathway in vitro. KM1468 inhibited IGF‐I‐mediated RPMI8226 cell growth in a dose‐dependent manner. In the NOD/SCID‐HAB model, treatment with KM1468 significantly inhibited the growth of RPMI8226 cells (p < 0.02). These results indicated that the growth of MM cells was predominantly stimulated not by serum‐derived IGFs, but by bone‐derived IGFs. Furthermore, the targeting of bone‐derived IGFs, using a neutralizing antibody, may offer a new therapeutic strategy for MM. © 2005 Wiley‐Liss, Inc.
Induction of strong and persistent MelanA/MART‐1‐specific immune responses by adjuvant dendritic cell‐based vaccination of stage II melanoma patients
Authors: Tuettenberg Andrea , Becker Christian , Huter Eva , Knop Jürgen , Enk Alexander H. , Jonuleit Helmut 
Published: December 2005

AbstractA significant percentage of stage II melanoma patients (tumor thickness >1 mm) remain at risk of tumor recurrence after primary tumor excision. In this study, we used tumor antigen‐pulsed dendritic cells as an adjuvant for immunization of these “high‐risk” melanoma patients after resection of the primary tumor. A total of 13 patients were included and vaccinated 6 times every 14 days with autologous dendritic cells pulsed with a MelanA/MART‐1 peptide in combination with a recall antigen. Antigen‐specific immune responses were monitored before, during and up to 1 year after the last vaccination. The majority of patients exhibited increased recall antigen‐specific CD4+ T cell responses upon vaccination. MelanA/MART‐1‐specific CD8+ T cells were expanded in 9/13 patients resulting in increased frequencies of memory cells in these patients. CD8+ T cells acquired the capacity to secrete IFN‐γ, to proliferate in culture in response to the tumor antigen used for vaccination and postvaccine samples contained MelanA/MART‐1‐specific T cells that recognized also the natural MelanA/MART‐1‐antigen expressed by tumor cells. Moreover, vaccination induced a long‐lived tumor antigen‐specific DTH‐reactivity in the majority of the patients, detectable even 12 months after the last immunization. These data demonstrate for the first time that vaccination with tumor antigen‐pulsed dendritic cells in a clinically adjuvant setting induces strong and persistent antigen‐specific T‐cell responses in tumor‐free stage II melanoma patients, suggesting that tumor protective T cell immunity can be achieved. © 2005 Wiley‐Liss, Inc.