bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of some tumor markers, acute phase proteins, sialic acid and lipid bound sialic acid before and after chemotherapy in stomach cancer
Authors: Cebi Aysegul , Mert Handan , Mert Nihat 
Published: February 2025

Objective: It was aimed to compare the some tumor markers, acute phase proteins, sialic acid and lipid bound sialic acid levels in patients with stomach cancer before and after chemotherapy to the healthy controls.
Material and Methods: Forty-eight patients with stomach adenocarcinoma and 20 healthy controls, totally 68 subjects were used. Blood samples were taken from all patients before and after chemotherapy and controls to analyse the levels of tumor markers (CA 125, CA 15-3, CA 19-9, CEA), acute phase proteins (CRP and fibrinogen) and SA (sialic acid), LSA (lipid bound sialic acid).
Results: Before chemotherapy the serum levels of CA 125, CA 15-3, CA 19-9, CEA SA, LSA, CRP and fibrinogen (107.30 U/ml, 65.74 U/ml, 295.86 U/ml, 108.57 ng/ml, 199.60 mg/dl, 41.89 mg/dl, 86.03 mg/l and 469.42 mg/dl ) were higher than after chemotherapy group (36.46 U/ml, 34.00 U/ml, 100.18 U/ml, 20.20 ng/ml, 87.67 mg/dl, 31.06 mg/dl, 57.04 mg/l and 379.04 mg/dl) and the controls (8.64 U/ml, 21.65 U/ml, 21.52 U/ml, 2.77 ng/ml, 73.75 mg/dl, 27.47 mg/dl, 2.37 mg/l, 303.5 mg/dl).
Conclusion: The serum levels of SA and LSA may be considered the indicators of poor/good prognosis of stomach cancer. CRP and fibrinogen are suggested as available biomarkers for diagnosis and prognosis in patients with stomach cancer.
Acute myeloid leukemia under lenalidomide therapy in a patient with multiple myeloma
Authors: Eser Ali , Tanrikulu Funda Pepedil , Tuglular Ayse Tulin Firatli 
Published: February 2025

A 53-year-old patient who had a 7 year history of multiple myeloma was diagnosed with high risk myelodysplastic syndrome while on lenalidomide treatment. Progression to acute myeloid leukemia has occurred during the following 4 months. Like our case, secondary primary malignancies (SPMs) can rarely complicate treatment of multiple myeloma. Although possible association between SPMs in patients receiving lenalidomide can be attributed to previous melphalan use, potential SPM risk with lenalidomide cannot still be ruled out safely
Factors affecting the burden on caregivers of stroke survivors in Turkey
Authors: Gorgulu Umit , Polat Ulku , Kahraman Burcu Bayrak , Ozen Sukru , Arslan Ersin 
Published: February 2025

Purpose: Caring for stroke patients leads to caregiver strain. Caregiver burden following stroke is increasingly recognised as a significant health care concern. This study was conducted to determine factors affecting the burden on caregivers of stroke survivors.
Design: This was a descriptive study.
Methods: Eighty caregivers of stroke patients hospitalized in the intensive and intermediate intensive care clinics of the Neurology Department of the Gazi University Health Research and Application Centre were included in the study. The Caregiver Introductory Form, the Barthel Index, the National Institutes of Health Stroke Scale, the Pittsburgh Sleep Quality Index and the Caregiver Burden Scale were used to collect the data.
Findings: In our study, a significant negative relationship (r=-0.854, p=0.000) was determined between the mean Barthel Index scores (24.55±7.69) and the mean Caregiver Burden Scale scores (57.52±14.35) and a significant positive relationship was determined between the mean Caregiver Burden Scale and the mean Pittsburgh Sleep Quality Index daytime dysfunction sub-component scores (1.30±1,42; r=0.223; p=0.046).
Conclusions: Our study has demonstrated that caregiver burden increased as the level of independence of stroke patients decreased and the daytime dysfunction sleep disorder became more prevalent as the caregivers’ burden increased.
Clinical Relevance: The burden of care could become as excessive as to impact. Negatively on the caregivers' sleep quality. To reduce the negative impact of burden of care influential factors should determine.
Effects of aminoguanidine treatment on endothelial nitric oxide synthase expression and nitric oxide levels in streptozotocin induced diabetic rats
Authors: Parmaksiz Ilker , Sirikci Onder , Bilsel Serpil , Akdeniz Humeyra Turan , Yavuz Dilek Gogas 
Published: February 2025

Objective: Formation of advanced glycation end products (AGE) in Diabetes Mellitus contribute to endothelial dysfunction by permanent modifications of proteins and decrease NO concentration which regulate vascular tonicity and thus endothelial functions. We investigated the effects of AGE inhibitor aminoguanidine (AG) treatment on endothelial nitric oxide synthase (eNOS) expression and NO levels in streptozotocin induced diabetic rats.
Material and method: 38 male Sprague-Dawley rats were separated into 4 groups. Group 1 was healthy controls without any intervention (HC group). Group 2 received AG in drinking water (HC+AG group). Third and fourth groups received 65 mg/kg streptozotocin intraperitoneally to induce diabetes. Group 3 was followed without further intervention (DM group). Group 4 received aminoguanidine in drinking water (DM+AG group). After 12 weeks, glucose, HbA1c, NO levels an eNOS expressions were determined.
Results: NO levels were significantly lower in DM and HC+AG groups compared to HC group. There was no significant difference between the NO levels of DM and DM+AG groups. eNOS protein levels in heart tissues were significantly lower in DM group than the HC group. eNOS levels were significantly higher in DM+AG than DM group. There was no significant difference in eNOS levels in kidney tissues among the groups.
Conclusion: Decreased NO levels in DM group was consistent with the literature. eNOS expression in heart tissues were decreased in DM group, their concentration were increased with AG therapy. Further studies are needed to elaboate the effects of AG in tissues and the side effects observed in some studies.
The evaluation of diagnostic performance of some enzymes for diagnosis and detection of breast cancer by ROC curve
Authors: Demir Halit , Keskin Sıddık , Demir Canan , Gokyer Halis 
Published: February 2025

Objective: In this study, it was aimed to examine the performance of Arylesterase (ARE), Paraoxonase-1 (PON-1) and Adenosine deaminase (ADA) enzymes to identify cancer patients and their stages with ROC curve in serum samples taken from patients diagnosed as breast cancer in the Medical Oncology services at Yüzüncü Yıl University.
Material and Methods: The 25 healthy controls and 25 breast cancer patients are included in this study. 8 patients are in stage-1, 9 patients are in stage-2 and 8 patients are in stage-3. Adenosine deaminase (ADA), Paraoxonase-1 (PON-1) and Arylesterase (ARE) activities were detected in serums with Spectrophotometric method. Descriptive statistics for the traits studied were presented as median, mean, standard deviation, minimum and maximum value. In terms of these traits, Kruskal-Wallis test was performed to find out whether there are no differences between stages and control group. In addition, ROC analysis was performed to evaluate the performances of enzymes to classify patient and control group.
Results: The differences between stage-1, stage-2, stage-3 and control group for Adenosine deaminase (ADA) enzyme activities were found statistically significant (p<0.01). Besides, the difference between stage-2 and stage-3 was found insignificant for Paraoxonase-1 (PON-1) and Arylesterase (ARE) enzyme activity. Last, the difference between them and stage-1 and control group was found statistically significant.
Conclusion: It can be inferred that sensitivity and specificity values of the enzymes are favorable high and they have outstanding performance to identify tumor stage as well as patient and control group. Therefore, these enzymes should be suggested as a “diagnostic test” to classify patients with breast cancer and control group.
Effect of a carbohydrate rich diet in vas deferens contractility in rats
Authors: Akdeniz Ekrem , Bilge Suleyman Sirri , Bolat Mustafa Suat , Firat Fatih , Agri Arzu Erdal , Alici Omer , Cinar Onder , Erdemir Fikret 
Published: February 2025

Objective: We aimed to investigate the effects of a Carbohydrate-rich diet on vas deferens contractility and histology.
Materials and Methods: Twenty mature male rats were subjected into two groups. The control group received regular food and water and the study group received regular food and a carbohydrate-rich liquid diet mixture of 37–40% fructose, 30–36% sucrose and 27–30% glucose instead of water and prepared stock diet was diluted with 50% water. Animals were weighted and sacrificed after six weeks and the vas deferens has been evaluated with in vitro studies. Five rats from both the control and study groups, were separated into subgroups for dapoxetine administration 4 hours before they were sacrificed.
Results: At the beginning of this study, the mean body weights were 228.6±6.7 g (range: 205-237) and 231.4±9.6 g (range: 202-243) in control and study groups, respectively. The mean body weights were 247.1±4.8 g (236-252) in the control group and 318.8±9.3 g (314-326) in the study group (p<0.001). Weight gain was more distinct in the study group when compared to control group (p<0.001) (9% vs 27.4%). Contractile responses were recorded in each group, including the dapoxetine subgroups, to various noradrenaline concentrations; all groups had similar results (p>0.05). Responses to Adenosine Three Phosphate (ATP) were also not significant (p>0.05). The contractile responses at the same frequencies of electrical field stimulation (EFS) were similar in both groups (p>0.05). Histological examinations showed no abnormalities in either group.
Conclusion: Carbohydrate-rich diet caused no increase in fibrotic activity, and pharmacological and histological properties remained stable, but caused significant weight gain over a short time period. Furthermore, dapoxetine had no effect on the contractility of the vas deferens.
The Extent to which Patients Hospitalized in a Certain Region of Turkey are Aware of the Defined Duties of Nurses
Authors: Kockar Cigdem , Genc Fatma , Yabaci Ayse , Ugur Arif 
Published: February 2025

Objective: Aim: This study was conducted to determine the extent to which patients hospitalized in a certain region of Turkey are aware of the defined duties of nurses. Material and Methods: The population of this descriptive study consisted of inpatients who were hospitalized in Giresun State Hospital between January-May 2015. The study included 207 patients. The study data were collected using this nursing practices perception form prepared by the investigators. The data were assessed through numeric and percentage analyses.
Results: Of the patients who took part in the study, 44.4% were between 59 and 79 years of age. A large majority of the patients responded to the questions asked them regarding nursing practices stating that nurses are engaged in treatments and measure temperature-heart rate-blood pressure (99.5% and 98.1%). 85.4% of the patients stated that they saw care giving as a duty of nurses. Approximately 97.1% of the participating patients stated that they administer first aid treatment in emergency cases and 59.9% that they help patients in exercising. Some 71% of the participating patients said that nurses arrange the diets of patients.
Conclusion: Based on the data obtained from the patients included in the study, it was concluded that a large majority of the inpatients were aware of the defined duties of nurses, but they thought that the practices of other healthcare professionals were also carried out by nurses.
Chronic myeloid leukemia in a pediatric population in the Congo
Authors: Ngolet Lydie Ocini , Ova Jenny Guelongo Okouango , Dokekias Alexis Elira 
Published: February 2025

Objective: Chronic myeloid leukemia is a rare hematological malignant disorder among children and adolescents for which data are scare in Africa. The aim of the study is to report clinical, biological feature of children with chronic myeloid leukemia. Additionally, describing cytogenetic response to imatinib and adherence of children to the drug.
Patients and Methods: A retrospective study was carried out from January 2007 to December 2016 (10 years) in the department of Hematology at the Teaching Hospital in Brazzaville. Four of 52 patients admitted during the period for chronic myeloid leukemia, were children. We collected data from these children’s medical records for analysis.
Results: They were four adolescents (2 boys and 2 girls) with a median age of 13.75 years at the time of diagnosis (range 11.2 and 16 years) that presented at the chronic phase of the the chronic myeloid leukemia. Delay diagnosis was 4 months. All adolescents presented with a voluminous splenomegaly (median size: 16.75 cm) and high white blood cells count: 133.37G/L (range: 60.7 and 219 G/L). The response to imatinib was poor. None patient was adherent to the treatment.
Conclusion: Chronic myeloid leukemia in children in the Congo is rare. Abdominal pain and voluminous splenomegaly are the main finding symptoms of the malignancy. Despite the delayed diagnosis of the disease, children present at chronic phase. The response to imatinib is poor as children are not adherent to the treatment.
Evoked potentials and other guiding factors of conversion from radiologically isolated syndrome to definite multiple sclerosis
Authors: Demir Serkan , Duzgun Eyup , Kafadar Cahit , Togrol Erdem Rifat , Senol Guney Mehmet , Cakir Akin 
Published: February 2025

Objective: Radiologically Isolated Syndrome (RIS) has become a popular subject recently with quite a number of follow-up and other clinical studies being done. A consensus on the approach to the patient with RIS is being tried to be established. The aim of our study was to assess the role of visual evoked potential (VEP) and somatosensory evoked potential (SEP) as a guiding factor for the conversion from Radiologically Isolated Syndrome (RIS) to definite Multiple Sclerosis (MS).
Material and methods: 49 RIS patients who were referred to GATA Haydarpasa Training Hospital Neurology Department between 2011-2015. All of the patients fullfillied the 2009 Okuda criteria for RIS and other differential diagnosis were excluded accordingly. VEP and SEP examinations made during the pre-MS RIS period were scanned retrospectively. For the VEP examination, the P100 latency and amplitudes, for the SEP examination, the P40 latency and amplitude was analysed.
Results: 49 patients were included in this study, the mean time of follow-up was 21,8 months. 63% of patients were female, while 37% were male. The mean age was 31,2 years. Among the four patients with abnormal SEPs, MS developed in three of them (75%) over time. This is statistically significant (p = 0.011). VEP and/or SEP was abnormal in 8 patients and MS developed in 4 (50%) of those (p=0.017). The following factors have a positive statistically significant correlation with conversion to MS: Presence of active plaques (r=0.461, p<0.001), presence of more than 9 plaques (r=0.287, p=0.046), VEP and/or SEP pathologies (r=0.402, p=0.004) and number of plaques (r=0.309, p=0.031). The most important factor for the transformation is the presence of active plaque which increases the risk 8.1-fold. The second important factor seems to be the presence of VEP and/or SEP abnormality, but this factor does not reach statistical significance.
Conclusion: In the conversion to MS risk from RIS, VEP- SEP examinations are important and should take its place in the follow-up of these patients.
Examination of Clinical and Demographic Characteristics of 14 Cases with Frontal Fibrosing Alopecia
Authors: Akbas Ayse , Kilinc Fadime 
Published: February 2025

Objective: Frontal fibrosing alopecia (FFA) is a rare type of cicatricial alopecia seen in postmenopausal women characterized with band-type frontal/frontotemporal hair traction and/or significant or complete loss of the eyebrows. We aimed to present the demographic, clinical and laboratory characteristics of female patients diagnosed and followed-up with FFA in our clinic by comparing these with the literature data.
Method: A total of 14 patients who admitted to our outpatient clinic with alopecia on the frontotemporal/frontal hairline and were clinically and/or histopathologically diagnosed with FFA between 2011 and 2016 were evaluated in a retrospective manner. The patients were reviewed in terms of the age of lesion onset, localization, accompanying symptom or disease, and treatment options.
Results: The ages of the patients who were followed-up in our outpatient clinic with FFA were between 52 and 73 (mean 2 years). Eight patients (57%) had total eyebrow loss,. Laboratory tests were in normal limits or negative. Comorbidities included thyroid disease, hypertension and coronary artery disease diabetes mellitus. For treatment, all patients were given systemic, intralesional and topical steroid, and topical minoxidil at various times. Four patients received hydroxychloroquine, 2 patients acitretin, 2 patients Vitamin E, 1 patient itraconazole, and 1 patient topical tacrolimus.
Conclusion: FFA should be considered in middle aged and elderly postmenopausal women presenting with hair loss complaints and were detected to have frontal hairline traction and cicatricial alopecia, and the diagnosis should be supported by biopsy. Thereby, the disease progression may be prevented or delayed with early diagnosis and proper treatment..
Compensation of MRI findings in asymptomatic patients with chronic low back pain
Authors: Levent Adiyeke  , Suavi Aydogmus  , Ozge Yapici Ugurlar  , Tahir Mutlu Duymus  
Published: February 2025

Objective: Chronic low back pain can originate from a number of constructs. It has a range of pathologies depending on multifactorial causes. In this study, we aimed to investigate in asymptomatic patients who compensation complaint of chronic low back pain in our outpatient clinic and demonstrate its for functionality in treatment planning.
Material and Methods: Magnetic Resonance Imaging (MRI) results of 78 asymptomatic patients (46 males, 32 females) who complained of low back pain for at least 12 weeks atMarch 2016 - January 2017 were examined. During MRI assessments, T1 and T2 weighted sagittal plane and transaxial images of the lumbar region (L1-S1) and radiology reports of these images were obtained for all patients. Degenerative disc disease, Bulging protrusion, Spinal canal stenosis and Nerve root compression re-evaluated and patient findings were assessed.
Results: There was no abnormality in the MRI results of 16 patients (20%) examined within the study criteria. Nerve root compression was detected in 17 patients (22%), spinal stenosis in 24 patients (30%) and disc degeneration or bulging in 57 patients (78%). There was no statistically significant difference in the incidence of pathologies by asymptomatic patient findings.
Conclusion: Chronic back pain is a disease that involves a wide range of pathologies. MRI scan provides detailed images to the clinician, it is difficult to make a specific diagnosis in the majority of patients with low back pain. Difficulty should be taken into account that the findings obtained by the clinician during assessment can also be seen in asymptomatic individuals
Thoracoabdominal asynchrony correlates with peripheral vascular resistance changes in a cohort of obese children
Authors: Marco Zaffanello  , Franco Antoniazzi  , Laura Tenero  , Michele Piazza  , Giuseppe Lippi  , Emma Gasperi  , Giorgio Piacentini  
Published: February 2025

Objective: The purpose of this study was to assess the relationship between the thoracoabdominal asynchrony (phase angle), as an index of inspiratory airflow resistance, pulse transit time arousal index (PTT Ar/I), as changes in peripheral vascular resistance and intrathoracic pressure, and obstructive apnea index (OA), Oxygen Desaturation Index (ODI), snoring (% estimated Total Sleep Time - eTST) and apnea-hypopnea index (AHI) in a cohort of exogenous obese children.
Material and Methods: Body mass index (BMI) and BMI z-scores were calculated according to age and sex in 36 consecutive obese children. Nasal patency, tonsil size, Friedman palate position scoring were also recorded. An overnight sleep respiratory recording was performed using an polygraphic ambulatory device.
Results: Subjects studies had normal to mild sleep respiratory involvement (assessed by respiratory polysomnographic scoring). Phase angle correlated significantly with PTT Ar/I, but not with AHI (n/hr), OA (n/hr), ODI (n/hr) and snoring (% eTST), even adjusting for nasal patency, tonsil hypertrophy, palate position and BMI (z-score).
Conclusion: Thoracoabdominal asynchrony (phase angle) is correlated with peripheral vascular resistance changes (PTT Ar/I), suggesting a subclinical upper respiratory airflow anomaly with autonomic activation in obese subjects
A rare cause of ptosis in emergency medicine practice: acute sinusitis case report
Authors: Eraybar Suna , Atmaca Serhat , Nennicioglu Yasemin , Sir Nazli , Kaya Halil 
Published: February 2025

Objective: Paranasal sinus infections are one of the most frequent causes of emergency service admissions. With increased incidence, complications are often local and classified according to the effecting side. Early identification of complication leads to reduce mortality and morbidity.
Case: A 22 year old male patient was admitted to our emergency department with ptosis on his right eyelid. Firstly he was admitted to the family doctor and received oral cephalosporin treatment for upper respiratory tract infection. Within three days, the ptosis was progressively occurred. No additional systemic sign was detected. The eyelid has slightly edema, not have redness, conjunctival hyperemia and loss of brow not observed. Eye movements were naturally, display pain in the outward view. For differential diagnosis central nervous system imaging was performed. Patient referred to otorhinolaryngology surgeon with prediagnosis of orbital cellulite and acute sinusitis. The patient was admitted to the otorhinolaryngology clinic for operation because of complicated sinusitis.
Conclusion: In the presence of acute sinusitis, infections may enter the orbital periosteum and spread to neighboring tissues. Computed tomography is a highly effective imaging modality for the evaluation of both paranasal infections and their complications. Patients with orbital complications must be hospitalized and immediate intravenous antibiotic therapy should be started.