bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFects of Exposure and Cognitive behavioral Therapy for chronic BACK pain (“EFFECT-BACK”): study protocol for a randomized controlled trial
Authors: Vogt Rabea , Haas Julia , Baumann Lukas , Sander Anja , Klose Christina , Riecke Jenny , Rief Winfried , Bingel Ulrike , Maser Dustin , Witthöft Michael , Keßler Jens , Zugaj Marco Richard , Ditzen Beate , Glombiewski Julia Anna 
Published: March 2024

Abstract
Introduction
Chronic back pain is a widespread medical condition associated with high socioeconomic costs and increasing prevalence. Despite the advanced implementation of multidisciplinary approaches, providing a satisfactory treatment offer for those affected is often not possible. Exposure therapy (EXP) promises to be an effective and economical form of treatment and in a previous pilot study showed to be superior to cognitive behavioral therapy (CBT) in reducing perceived limitations of movement. The current study aims to further compare the efficacy of both treatment methods and identify those patient groups that particularly benefit from EXP.

Methods
The general objective of this randomized multicenter clinical trial (targeted N = 380) is to improve and expand the range of treatments available to patients with chronic back pain. As the primary objective of the study, two different psychological treatments (EXP and CBT) will be compared. The primary outcome measure is a clinically significant improvement in pain-related impairment, measured by the QPBDS, from baseline to 6-month follow-up. Secondary outcome measures are absolute changes and clinically significant improvements in variables coping, psychological flexibility, depressiveness, catastrophizing, exercise avoidance and fear of exercise, and intensity of pain. Participants are recruited in five psychological and medical centers in Germany and receive ten sessions of manualized therapy by trained licensed CBT therapists or clinical psychologists, who are currently in their post-gradual CBT training. Potential predictors of each treatment’s efficacy will be explored with a focus on avoidance and coping behavior.

Conclusion
This study will be the first RCT to compare CBT and EXP in chronic back pain in a large sample, including patients from different care structures due to psychological and medical recruitment centers. By identifying and exploring potential predictors of symptom improvement in each treatment group, this study will contribute to enable a more individualized assignment to treatment modalities and thus improves the care situation for chronic back pain and helps to create a customized treatment program for subgroups of pain patients. If our findings confirm EXP to be an efficacious and efficient treatment concept, it should gain more attention and be further disseminated.

Trial registration
ClinicalTrials.gov NCT05294081. Registered on 02 March 2022.
The effect of donation frequency on donor health in blood donors donating plasma by plasmapheresis: study protocol for a randomized controlled trial
Authors: Haugen Morten , Magnussen Karin , Aarsland Tonje Eiane , Nissen-Meyer Lise Sofie Haug , Strand Tor A. 
Published: March 2024

Abstract
Background
The demand for plasma products is growing, necessitating an increase in plasma collection by plasmapheresis. While the 20th edition of the European Guidelines permits plasma donors in Europe to donate with 96-h donation intervals, the potential short- and long-term consequences of high-frequency plasma donations on donor health remain unknown. This study aims to measure the effect of plasma donation frequency on plasma protein composition, including total serum protein (TSP) and immunoglobulin G (IgG), in Norwegian male blood donors.

Methods
This randomized controlled trial (RCT) included 120 male blood donors who were randomized into two intervention groups and one control group: high-frequency plasma donors (HFPDs) who donated 650 mL of plasma 3 times every 2 weeks, whereas regular-frequency plasma donors (RFPDs) who donated 650 mL of plasma 1 time every 2 weeks. The control group consisted of whole blood donors. The primary outcomes are the concentrations of TSP and IgG.

Discussion
The findings from this study may have implications for recommendations related to donor health and plasma donation frequencies and may contribute to supporting the strategic independence of plasma products in Norway and Europe without compromising donor health.

Trial registration
ClinicalTrials.gov: NCT05179200. Registered December 20th, 2021.
Impact assessment of onchocerciasis through lymphatic filariasis transmission assessment surveys using Ov-16 rapid diagnostic tests in Sierra Leone
Authors: Kargbo-Labour Ibrahim , Bah Mohamed S. , Melchers Natalie V. S. Vinkeles , Conteh Abdulai , Redwood-Sawyerr Victoria , Stolk Wilma A. , Paye Jusufu , Sonnie Mustapha , Veinoglou Amy , Koroma Joseph B. , Hodges Mary H. , Weaver Angela M. , Zhang Yaobi 
Published: March 2024

Abstract
Background
Onchocerciasis is endemic in 14 of Sierra Leone's 16 districts with high prevalence (47–88.5%) according to skin snips at baseline. After 11 rounds of mass treatment with ivermectin with good coverage, an impact assessment was conducted in 2017 to assess the progress towards eliminating onchocerciasis in the country.

Methods
A cluster survey was conducted, either integrated with lymphatic filariasis (LF) transmission assessment survey (TAS) or standalone with the LF TAS sampling strategy in 12 (now 14) endemic districts. Finger prick blood samples of randomly selected children in Grades 1–4 were tested in the field using SD Bioline Onchocerciasis IgG4 rapid tests.

Results
In total, 17,402 children aged 4–19 years in 177 schools were tested, and data from 17,364 children aged 4–14 years (14,230 children aged 5–9 years) were analyzed. Three hundred forty-six children were confirmed positive for Ov-16 IgG4 antibodies, a prevalence of 2.0% (95% CI 1.8–2.2%) in children aged 4–14 years with prevalence increasing with age. Prevalence in boys (2.4%; 95% CI 2.1–2.7%) was higher than in girls (1.6%; 95% CI 1.4–1.9%). There was a trend of continued reduction from baseline to 2010. Using data from children aged 5–9 years, overall prevalence was 1.7% (95% CI 1.5–1.9%). The site prevalence ranged from 0 to 33.3% (median prevalence = 0.0%): < 2% in 127 schools, 2 to < 5% in 34 schools and ≥ 5% in 16 schools. There was a significant difference in average prevalence between districts. Using spatial analysis, the Ov-16 IgG4 antibody prevalence was predicted to be < 2% in coastal areas and in large parts of Koinadugu, Bombali and Tonkolili Districts, while high prevalence (> 5%) was predicted in some focal areas, centered in Karene, Kailahun and Moyamba/Tonkolili.

Conclusions
Low Ov-16 IgG4 antibody prevalence was shown in most areas across Sierra Leone. In particular, low seroprevalence in children aged 5–9 years suggests that the infection was reduced to a low level after 11 rounds of treatment intervention. Sierra Leone has made major progress towards elimination of onchocerciasis. However, attention must be paid to those high prevalence focal areas.

Graphical Abstract
Computed tomography angiography of liver alveococcosis: a case report
Authors: Magzumova Saodatkhon , Isroilov Umidjon , Djuraeva Nigora , Khaybullina Zarina , Amirkhamzaev Aybek , Vakhidova Nargiza , Abdukhalimova Khanum , Sultanov Alisher , Abdullaev Bekhzod 
Published: March 2024

Abstract
Background
Alveococcosis, helminthiasis caused by the larvae of Alveococcus multilocularis, is characterized by the formation of parasitic nodes in the liver. This clinical case is a rare occurrence of liver alveococcosis in Uzbekistan.

Case presentation
We present a case of a 33-year-old Asian woman from Uzbekistan who complained of discomfort in the epigastric region and right hypochondrium, along with general weakness. She had been experiencing symptoms for 5 months when a routine ultrasound examination revealed a structural formation in the liver. Patient was investigated by using contrast enhanced computed tomography (CT) and diagnosed with liver alveococcosis with multiple lesions. Patient underwent diagnostic laparotomy with obtaining gross specimen, biomaterial was examined microscopically and found that there were small fragments of fibrous tissue determined together with small groups of cystic formations and walls consisted of chitin. Moreover, contrast enhanced CT allowed us to differentiate liver alveococcosis from cavernous hemangioma, hepatocellular carcinoma, and liver metastases from unknown source.

Conclusion
Contrast enhanced CT plays a major role in differentially diagnosing liver alveococcosis and makes it the first line method of choice for the consideration of the future treatment and surgical interventions.
Painting on the margins: investigating the pigments, media, and techniques of Séraphine Louis
Authors: Haddad Abed , Sutherland Ken , Centeno Silvia A. , Kavich Gwénaëlle M. , Kokkori Maria , Hoover Caroline , Hartman-Drumm Diana , Balcar Nathalie , Barabant Gilles 
Published: March 2024

Abstract
The richly decorative and imaginative works by French artist Séraphine Louis (1864–1942) have long elicited fascination, and her working methods have often eluded art historians and conservators alike. Working in secret and outside established art circles, Séraphine employed materials such as natural resin varnishes and was said to have used household paints in addition to traditional artists' oil paints. In this study of six works in the collections of the Musée d'Art et d'Archéologie, Senlis (MAA), The Museum of Modern Art, New York (MoMA), and The Metropolitan Museum of Art, New York (MMA), attention was given to Séraphine's choice of colors and paints, in addition to identifying possible additions to or manipulations of painting media by the artist. Technical imaging was carried out using UVF to visualize the extent of Séraphine's use of natural resins. Analysis of the palette relied on XRF techniques and limited sampling for analysis by Raman and µ-FTIR spectroscopies. Overall, the following pigments were identified: lead white, zinc white, carbon-based black, red and brown ochres, umber, vermilion, alizarin lake, rhodamine B lake, Prussian blue, cobalt blue, ultramarine blue, chrome green, emerald green, viridian, cadmium yellow, and lead chromates, including chrome yellow deep and light, zinc yellow, and chrome orange. THM-Py-GCMS analysis of selected samples supported the documentary evidence of Séraphine's use of household oil paints; a single instance of a cellulose nitrate enamel paint was additionally determined by µ-FTIR. The chromatographic analysis also indicated a natural plant resin in her varnishes, probably dammar in combination with pine resin. Overall, this material investigation, accompanied by the art historical record, better reveals the techniques of an experimental painter whose works have come to epitomize French outsider artists of the early twentieth century.
Microbiome changes through the ontogeny of the marine sponge Crambe crambe
Authors: Turon Marta , Ford Madeline , Maldonado Manuel , Sitjà Cèlia , Riesgo Ana , Díez-Vives Cristina 
Published: March 2024

Abstract
Background
Poriferans (sponges) are highly adaptable organisms that can thrive in diverse marine and freshwater environments due, in part, to their close associations with internal microbial communities. This sponge microbiome can be acquired from the surrounding environment (horizontal acquisition) or obtained from the parents during the reproductive process through a variety of mechanisms (vertical transfer), typically resulting in the presence of symbiotic microbes throughout all stages of sponge development. How and to what extent the different components of the microbiome are transferred to the developmental stages remain poorly understood. Here, we investigated the microbiome composition of a common, low-microbial-abundance, Atlantic-Mediterranean sponge, Crambe crambe, throughout its ontogeny, including adult individuals, brooded larvae, lecithotrophic free-swimming larvae, newly settled juveniles still lacking osculum, and juveniles with a functional osculum for filter feeding.

Results
Using 16S rRNA gene analysis, we detected distinct microbiome compositions in each ontogenetic stage, with variations in composition, relative abundance, and diversity of microbial species. However, a particular dominant symbiont, Candidatus Beroebacter blanensis, previously described as the main symbiont of C. crambe, consistently occurred throughout all stages, an omnipresence that suggests vertical transmission from parents to offspring. This symbiont fluctuated in relative abundance across developmental stages, with pronounced prevalence in lecithotrophic stages. A major shift in microbial composition occurred as new settlers completed osculum formation and acquired filter-feeding capacity. Candidatus Beroebacter blanensis decreased significatively at this point. Microbial diversity peaked in filter-feeding stages, contrasting with the lower diversity of lecithotrophic stages. Furthermore, individual specific transmission patterns were detected, with greater microbial similarity between larvae and their respective parents compared to non-parental conspecifics.

Conclusions
These findings suggest a putative vertical transmission of the dominant symbiont, which could provide some metabolic advantage to non-filtering developmental stages of C. crambe. The increase in microbiome diversity with the onset of filter-feeding stages likely reflects enhanced interaction with environmental microbes, facilitating horizontal transmission. Conversely, lower microbiome diversity in lecithotrophic stages, prior to filter feeding, suggests incomplete symbiont transfer or potential symbiont digestion. This research provides novel information on the dynamics of the microbiome through sponge ontogeny, on the strategies for symbiont acquisition at each ontogenetic stage, and on the potential importance of symbionts during larval development.
Knowledge, attitude and practice towards intestinal schistosomiasis among school-aged children and adults in Amhara Regional State, northwest Ethiopia. A cross-sectional study
Authors: Alemu Getaneh , Nibret Endalkachew , Amor Arancha , Munshea Abaineh , Anegagrie Melaku 
Published: March 2024

Abstract
Background
Schistosoma mansoni causes intestinal schistosomiasis (SCH) in all regions of Ethiopia. Despite many years of mass treatment, the prevalence has not dropped significantly. The reduction of SCH transmission demands the integration of deworming with safe water, sanitation, and hygiene (WASH) activities. Adequate knowledge and a positive attitude towards SCH are critical to practicing those interventions. However, data on the knowledge, attitude, and practice (KAP) level in school and community settings is limited in Ethiopia.

Methods
School and community-based cross-sectional studies were conducted from February to June 2023 among 634 school-aged children (SAC) and 558 adults. A pre-tested questionnaire was used to collect socio-demographic and KAP data. Records were entered and analyzed using SPSS software version 21. Correct responses for each of the KAP questions were scored as one, while incorrect or ‘I don’t know’ responses were scored as zero. Good knowledge, a positive attitude and good practice were declared if percentage scores were ≥ 80%, ≥ 90% and ≥ 75%, respectively.

Results
Only 229 (19.2%) respondents, comprising 91 (14.4%) SAC and 138 (24.7%) adults, had ever heard of SCH. Adults, males, and urban residents had higher awareness level compared to their respective counterparts (p < 0.05). Only 28.4% of aware respondents knew that swimming or bathing in freshwater is a risk factor for schistosoma infection; 10.9% knew the etiologic agent; and 14.4% mentioned at least one sign and symptom associated with SCH. The majority (97.8%) of the respondents were willing to take therapeutic drugs, but only 37.6% believed that SCH is a serious disease. Regarding risky practices, 89.5% practiced swimming or bathing in freshwater, and 25.3% had no access to piped water. Among the aware respondents, only 18 (7.9%) had good knowledge, while 30 (13.1%) had a positive attitude towards SCH. Ninety-nine (43.2%) respondents had good Schistosoma infection prevention practices.

Conclusions
The knowledge, attitude, and preventive practice level towards schistosomiasis are low in the study area. Therefore, strengthening school and community-based health education, along with mass drug administration (MDA), WASH, and a vector control program, is recommended for preventing SCH.
In vitro study of the embolic characteristics of imipenem/cilastatin particles
Authors: Nakamura Hiroki , Yamamoto Akira , Fukunaga Takeshi , Watanabe Hiroyuki , Ito Kosuke , Higaki Atushi , Kanki Akihiko , Fukukura Yoshihiko , Tamada Tsutomu 
Published: March 2024

Abstract
Background
Imipenem/cilastatin (IPM/CS) has long been administered intravenously as a carbapenem antibiotic. However, since this agent is poorly soluble in liquid, occasional reports have described its use as a short-acting, temporary embolic agent. The purpose of this study was to elucidate the characteristics of IPM/CS particles, which are thought to have pain-relieving effects against osteoarthritis-related pain, as an embolic agent.

Methods
Three aspects of IPM/CS as an embolic agent were evaluated in vitro: particle size; particle shape; and change in particle size over time. For particle size, the long diameter was measured.

Results
Mean particle size (n=244) was 29.2±12.0 µm (range, 1–60 µm). Shape (n=109) was round in 18.35%, elliptical in 11.93%, and polygonal in 69.72%, showing that most particles were polygonal. In observations of changes in particle size over time (n=9), particles had decreased to 75% of their original size at 82±10.7 min, 50% at 89.3±9.14 min, 25% at 91.3±8.74 min, complete dissolved at 91.8±9.02 min. A rapid shrinkage in diameter was seen in the final period.

Conclusions
IPM/CS particles are ultrafine and the majority display a polygonal shape. This substance shows ultra-short embolic activity. This study revealed the characteristics of a substance that demonstrates an embolic effect not found in existing embolic materials.
Postoperative breast cancer surveillance: Can contrast-enhanced spectral mammography solve the diagnostic dilemma?
Authors: El-nasr Safaa Ibrahim Saif , Ali Neveen Gamal Fathy , Hegazy Rania Mohamed Abbas , Safwat Yehia Mohamed , Onsy Marwa Mohamed Mohamed 
Published: March 2024

Abstract
Background
For women worldwide, breast cancer is considered a significant public health concern. The development of enormous changes caused by surgery and irradiation makes diagnosing the postoperative breast a complicated procedure. The current study aimed to detect the additive role of contrast-enhanced spectral mammogram (CESM) to digital mammogram and US in the surveillance of postoperative breast cancer patients.

Methods
This research was conducted on 74 female patients with a prior history of surgery for the treatment of previous breast cancer. All patients had undergone sonomammography and CESM. Benign lesions were followed up, while suspicious lesions were biopsied.

Results
The current study revealed that CESM can enhance the sensitivity, specificity our overall accuracy of sonomammography in the surveillance of breast cancer patients after surgery.

Conclusion
Adding CESM to properly selected patients in the surveillance of breast cancer patients after surgical treatment can enhance the diagnostic performance of conventional imaging modalities.
A case series of co-infection in Mycobacterium tuberculosis and other pathogens: insights from nanopore sequencing
Authors: Shu Wei , Chen Wenlong , Yao Lin , Sun Ming , Gao Min , Wan Zanyan , Xie Wei , Lei Yanjuan , Wang Tao 
Published: March 2024

Abstract
Background
Tuberculosis (TB) continues to be a major global health burden, and co-infection with other pathogens further complicates the diagnosis and treatment of this infectious disease. The present retrospective study aimed to evaluate the clinical utility of nanopore sequencing in identifying co-infection caused by Mycobacterium tuberculosis (M.tb) and other pathogens.

Methods
Patients with M.tb co-infection from December 2021 to March 2023 at the Jiangxi Provincial Chest Hospital were retrospectively studied. Data were collected including demographics, symptoms, imaging findings, pathogen diagnosis tests, and treatment history. Pathogen tests involved culture, AFB smear, Xpert MTB/RIF, and nanopore sequencing.

Results
The enrolled patients included 20 M.tb cases and three nontuberculous mycobacteria (NTM) cases co-infected with other pathogens. Common clinical symptoms included cough (47.83%), expectoration (34.78%), and asthma (17.39%). Radiological examinations showed typical features of pulmonary tuberculosis, including nodules (73.91%), cord-like shadows (34.78%), cavities (34.78%), and destroyed lung manifestations (17.39%). Nanopore sequencing identified M.tb in a significant majority of the cases (86.96%), outperforming traditional culture tests (39.13%), acid-fast bacilli (AFB) tests (27.27%), and Xpert MTB/RIF (53.84%) tests. Notably, nanopore sequencing revealed that M.tb was frequently co-infected with Candida albicans, Klebsiella pneumoniae, and Mycobacterium abscessus. Three specific cases of co-infection with distinct diagnosis and treatment characteristics were presented in detail. They illustrated the complexity of TB co-infection management and the potential of nanopore sequencing for accurate diagnosis and informing the tailored therapeutic approaches.

Conclusion
Nanopore sequencing-based metagenomics method can help clinicians to identify TB co-infection patterns and formulate a rational drug regimen in time.
Assessing the performance of urban heritage conservation projects – influencing factors, aspects and priority weights
Authors: Abdul Huq Sunena , Puthuvayi Bimal 
Published: March 2024

AbstractHeritage conservation in urban areas involves complex systems often faced with the dilemmas of maintaining the built form’s historical character, improving infrastructure, and managing development through stakeholder cooperation. At present, the performance of any conservation project is solely vested in conserving the built fabric. Evaluation tools for urban heritage conservation projects do not have provisions for measuring the subjective value of stakeholders who are part of the heritage setting. This study tries to identify and prioritise the factors that need to be considered when developing a conservation project performance assessment model for an urban heritage conservation project from the perspective of experts that can be further evaluated from the perspective of stakeholders. As these complex systems can be better viewed in the context of developing countries, the case of India is adopted. From a literature review, factors that contribute to the outcome of an urban heritage conservation project were identified and categorised into six aspects: the physical, social, economic, cultural, political, and continuity aspects. Through an expert survey, the factors that constituted each aspect were filtered using the feature selection method of correlation to avoid factors that may seem related. The factors under each aspect were ranked using a weighted average ranking method to identify the most prioritised factors determining the outcome of an urban heritage conservation project. The priority weights of the aspects were calculated using Saaty’s analytic hierarchy process. The results show that the cultural aspect was the most important aspect, followed by the continuity aspect. The social and physical aspects were prioritised similarly, followed by the economic and political aspects. This study is distinctive because it identifies the influential factors that can help develop a conservation project performance assessment model for an urban heritage conservation project.