bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vohalni trening kot učinkovita podpora pri rehabilitaciji voha pacientov z vohalno disfunkcijo
Authors: Drenovec Tadeja 
Published: March 2024

Uvod: Motnje voha so pogoste pri okužbah dihal in vplivajo na kakovost življenja, saj imajo nekateri pacienti lahko moten voh vse življenje. Kot pomoč pri rehabilitaciji voha obstaja vohalni trening, ki je nefarmakološka, nekirurška in stroškovno učinkovita metoda zdravljenja pacientov z motnjami voha zaradi različnih indikacij. Namen raziskave je raziskati, kakšni so učinki vohalnega treninga pri pacientih z vohalno disfunkcijo.Metode: Uporabljen je bil pregled strokovne in znanstvene literature. Iskanje literature je potekalo po podatkovnih bazah Web of Science, CINAHL in Pubmed. Vključena je bila literatura med letoma 2019 in 2022. Pri iskanju so bile uporabljene kombinacije ključnih besed: voh, motnje voha, anozmija. Potek iskanja in izbor raziskav smo prikazali s pomočjo diagrama PRISMA. Tematska analiza je potekala na način kodiranja rezultatov.Rezultati: Iz celotnega niza smo pridobili 253 zadetkov, med katerimi smo v končno analizo uvrstili šest kvantitativnih raziskav, ki so opisovale uporabo ter učinke vohalnega treninga za zdravljenje vohalne disfunkcije. Rezultati iskanja literature so bili kritično ovrednoteni z orodji JBI (JBI, 2020). Glavni izpostavljeni vsebinski področji sta bili: izidi vohalnega treninga in lastnosti vohalnega treninga.Diskusija in zaključek: Vohalni trening pomembno vpliva na vračanje in izboljšanje vonjanja. Gre za učinkovito podporo pri rehabilitaciji voha. Za prihodnje raziskovanje področja se predlaga raziskava predvsem na področjih razločevanja in zaznavanja voha po uporabi vohalnega treninga.
k-convex solutions for multiparameter Dirichlet systems with k-Hessian operator and Lane-Emden type nonlinearities
Authors: He Xingyue , Gao Chenghua , Wang Jingjing 
Published: March 2024

Abstract
In this article, our main aim is to investigate the existence of radial

k

k

-convex solutions for the following Dirichlet system with

k

k

-Hessian operators:

S

k

(

D

2

u

)

=

λ

1

ν

1

(

∣
x
∣

)

(

−
u

)

p

1

(

−
v

)

q

1

in

ℬ

(

R

)

,

S

k

(

D

2

v

)

=

λ

2

ν

2

(

∣
x
∣

)

(

−
u

)

p

2

(

−
v

)

q

2

in

ℬ

(

R

)

,

u
=
v
=
0

on

∂
ℬ

(

R

)

.

\left\{\begin{array}{ll}{S}_{k}\left({D}^{2}u)={\lambda }_{1}{\nu }_{1}\left(| x| ){\left(-u)}^{{p}_{1}}{\left(-v)}^{{q}_{1}}& {\rm{in}}\hspace{1em}{\mathcal{ {\mathcal B} }}\left(R),\\ {S}_{k}\left({D}^{2}v)={\lambda }_{2}{\nu }_{2}\left(| x| ){\left(-u)}^{{p}_{2}}{\left(-v)}^{{q}_{2}}& {\rm{in}}\hspace{1em}{\mathcal{ {\mathcal B} }}\left(R),\\ u=v=0& {\rm{on}}\hspace{1em}\partial {\mathcal{ {\mathcal B} }}\left(R).\end{array}\right.

Here,

u

p

1

v

q

1

{u}^{{p}_{1}}{v}^{{q}_{1}}

is called a Lane-Emden type nonlinearity. The weight functions

ν

1

,

ν

2

∈
C

(

[

0
,
R

]

,

[

0
,
∞

)

)

{\nu }_{1},{\nu }_{2}\in C\left(\left[0,R],\left[0,\infty ))

with

ν

1

(

r

)

>
0
<

ν

2

(

r

)

{\nu }_{1}\left(r)\gt 0\lt {\nu }_{2}\left(r)

for all

r
∈

(

0
,
R

]

r\in \left(0,R]

,

p

1

,

q

2

{p}_{1},{q}_{2}

are nonnegative and

q

1

,

p

2

{q}_{1},{p}_{2}

are positive exponents,

ℬ

(

R

)

=

{

x
∈

R

N

:
∣
x
∣
<
R

}

{\mathcal{ {\mathcal B} }}\left(R)=\left\{x\in {{\mathbb{R}}}^{N}:| x| \lt R\right\}

,

N
≥
2

N\ge 2

is an integer,

N

2

≤
k
≤
N

\frac{N}{2}\le k\le N

. In order to achieve our main goal, we first study the existence of radial

k

k

-convex solutions of the above-mentioned systems with general nonlinear terms by using the upper and lower solution method and Leray-Schauder degree. Based on this, by constructing a continuous curve, which divides the first quadrant into two disjoint sets, we obtain the existence and multiplicity of radial

k

k

-convex solutions for the system depending on the parameters

λ

1

{\lambda }_{1}

,

λ

2

{\lambda }_{2}

and the continuous curve.
Unlocking the potential of oncology biomarkers: advancements in clinical theranostics
Authors: Dubey Ankit Kumar , Kaur Ishnoor , Madaan Reecha , Raheja Shikha , Bala Rajni , Garg Manoj , Kumar Suresh , Lather Viney , Mittal Vineet , Pandita Deepti , Gundamaraju Rohit , Singla Rajeev K. , Sharma Rohit 
Published: March 2024

Abstract

Introduction
Cancer biomarkers have revolutionized the field of oncology by providing valuable insights into tumor changes and aiding in screening, diagnosis, prognosis, treatment prediction, and risk assessment. The emergence of “omic” technologies has enabled biomarkers to become reliable and accurate predictors of outcomes during cancer treatment.

Content
In this review, we highlight the clinical utility of biomarkers in cancer identification and motivate researchers to establish a personalized/precision approach in oncology. By extending a multidisciplinary technology-based approach, biomarkers offer an alternative to traditional techniques, fulfilling the goal of cancer therapeutics to find a needle in a haystack.

Summary and Outlook
We target different forms of cancer to establish a dynamic role of biomarkers in understanding the spectrum of malignancies and their biochemical and molecular characterization, emphasizing their prospective contribution to cancer screening. Biomarkers offer a promising avenue for the early detection of human cancers and the exploration of novel technologies to predict disease severity, facilitating maximum survival and minimum mortality rates. This review provides a comprehensive overview of the potential of biomarkers in oncology and highlights their prospects in advancing cancer diagnosis and treatment.
A calibration method for vector network analyzers using a line and three or more offset-reflect standards
Authors: Liu Yujie , Wan Guobin , Wu Changying , Yashchyshyn Yevhen , Wang Yingfan , Tu Limin 
Published: March 2024

Abstract
This article proposes a method for two-port vector network analyzer (VNA) calibration that uses a line standard and three or more offset-reflect standards (LnΓ, where n is the number of offset-reflect standards and n ≥ 3). The reflection coefficient of the highly reflecting offset-reflect standards and the propagation constant of the transmission line are unknown for this calibration method, but they can be obtained in the process of calculating the VNA calibration error coefficients. In the LnΓ calibration method, the calibration fixtures are all equal in mechanical length. Therefore, compared with the thru-reflect-line (TRL) method, this calibration method is convenient when the test fixtures of both sides of the VNA are fixed or difficult to move during the measurement. To further simplify the experimental operation, a corrugated reflector is also designed. In this calibration method, only one corrugated reflector used as the offset-reflect standard is needed. Different offset-reflect standards are realized easily by changing the position on the microstrip line. The proposed LnΓ calibration method is accurate, which is proven by theoretical analysis, simulations, and measurements.
Rhizomatic Healthcare: The Digital Transformation of France’s Medical Landscape
Authors: Wagner Anne 
Published: March 2024

Abstract
This paper explores the implications of the digital advancements on patient empowerment and the role of healthcare professionals. It examines the challenges and opportunities presented by this digital shift, including data privacy concerns, the need for continuous technological adaptation, and the potential for increased healthcare accessibility. The paper underscores the critical importance of legal and ethical considerations in shaping a sustainable and equitable digital healthcare landscape. Through this exploration, the paper aims to provide a comprehensive overview of the ongoing digital revolution in French healthcare and its broader implications for the global healthcare sector.
Maternal separation influences hepatic drug-metabolizing CYP450 gene expression without pathological changes in adult mice
Authors: Jarrar Yazun Bashir , Ashour Walaa’ , Madani Abdalla , Jarrar Qais , Abulebdah Dina , Jamous Yahya F. , Labban Samah Y. , Tazkarji Mariam 
Published: March 2024

Abstract

Objectives
The principal motive of this study is to explore the influence maternal separation (MS) exhibits on the mRNA expression of major drug metabolizing-cyp450s in parallel with the assessment of pathological changes that can be induced by MS in the livers of experimental mice.

Methods
Eighteen Balb/c mouse pups, comprising of both males and females, were separated from their mothers after birth. Following a six-week period during when the pups became adults, the mice were sacrificed and their livers were isolated for analysis of weight, pathohistological alterations, and the mRNA expression of drug metabolizing cyp450 genes: cyp1a1, cyp3a11, cyp2d9, and cyp2c29.

Results
The study demonstrated that MS markedly downregulated (p<0.05) the mRNA expression of all tested drug-metabolizing cyp450s in livers of female and male mice. Furthermore, the mRNA levels of major drug-metabolizing cyp450s were notably lower (p<0.05) in livers of female MS mice as compared with male MS mice. It was found that values of the total body weight and liver weight of MS mice did not vary significantly (p>0.05) from those of the control groups. Additionally, histological examination revealed that the hepatic tissue of MS mice was normal, similar to that of the control mice.

Conclusions
In summary, MS downregulates the gene expression of major hepatic drug-metabolizing cyp450s without inducing pathological alterations in the livers of mice. These findings provide an explanation for the heterogeneity in pharmacokinetics and drug response of patients with early life stress.
Subjective transformation in poeticized language and the formation of poeticness
Authors: Yang Hui 
Published: March 2024

Abstract
As one locus of extraordinary collocations, poeticized language features expressions that depart from the physical reality, involving the subjective transformation of objects in the mental space. Increasing subjectivity renders extraordinary collocations resistant to rational readings, resulting in two types of constructions: “innovative” collocations and “self-created” collocations. The meaning construction in the former is easier to achieve than in the latter; the former entails the “rational evaluation” and the latter the “speculative evaluation” processes in metalanguage. With its rule-breaking defiance caused by meaning obscurity compensated for by rich implied meaning and positive aesthetic feedback, the “self-created” collocations are regarded as poetic and re-accepted by the system. Therefore, the so-termed “poeticness” is derived from the positive feedback during the speculative evaluation process and constitutes the main substance of aesthetic interpretation.
Downregulation of lncRNA XLOC_032768 in diabetic patients predicts the occurrence of diabetic nephropathy
Authors: Li Baohua , Wu ZhiLe , Xu Haofeng , Ye HuiLing , Yang Xin 
Published: March 2024

Abstract
LncRNA XLOC_032768 is reported to prevent renal tubular epithelial cells from cisplatin-induced apoptosis, suggesting its involvement in the development of kidney injury. The present study aimed to explore the role of XLOC_032768 in diabetic nephropathy (DN). The present study enrolled a total of 140 healthy controls (Control group) and 140 patients with type 2 diabetes (Diabetes group). Expression of XLOC_032768 in plasma from these participants was analyzed by performing RT-qPCR. The 140 diabetic patients were followed up for 5 years to monitor the occurrence of diabetic complications. The role of XLOC_032768 in predicting the occurrence of diabetic complications, including DN, diabetic cardiomyopathy (DC), diabetic retinopathy (DR), and diabetic foot (DF) were analyzed by plotting receiver operating characteristic curves and complication-free curves. On the day of admission, plasma levels of XLOC_032768 were not significantly different between Control and Diabetes groups. During follow-up, a total of 22, 15, 13, and 15 cases were diagnosed as DN, DC, DR, and DF, respectively. On the day of diagnosis, plasma levels of XLOC_032768 were only decreased in DN group, but not in other groups, compared to plasma levels of XLOC_032768 on the day of admission. Using plasma levels of XLOC_032768 on the day of admission as a biomarker, potential DN patients were effectively separated from patients with other potential complications and diabetic patients without complications. The 140 diabetic patients were grouped into high and low XLOC_032768 level groups. It was observed that low XLOC_032768 level group showed increased occurrence of DN, but not other complications, compared to high XLOC_032768 level group. Therefore, the downregulation of lncRNA XLOC_032768 in diabetic patients may predict the occurrence of DN.
Menopausal transition alters female skeletal muscle transcriptome
Authors: Juppi Hanna-Kaarina , Korhonen Tia-Marje , Sievänen Tero , Kovanen Vuokko , Kujala Urho M. , Aukee Pauliina , Cronin Neil , Sipilä Sarianna , Karvinen Sira , Laakkonen Eija K. 
Published: March 2024

Abstract

Objectives
Although skeletal muscle is a target of hormonal regulation, the muscle transcriptome, including messenger-RNA (mRNA), long non-coding RNAs (lncRNAs), and microRNAs (miRNAs) has not previously been studied across the menopausal transition. Thus, we took a multi-RNA-omics approach to get insight into transcriptome-wide events of menopause.

Methods
We included baseline and follow-up muscle samples from seven early (EarlyMT) and 17 late perimenopausal (LateMT) women transitioning to early postmenopause during the study. Total RNA was sequenced and differential expression (DE) of the transcriptome was investigated. Gene functions were investigated with pathway analyses and protein level expression with Western Blot.

Results
We found 30 DE mRNA genes in EarlyMT and 19 in LateMT participating in pathways controlling cell death, growth, and interactions with the external environment. Lack of protein level changes may indicate a specific role of the regulatory RNAs during menopause. 10 DE lncRNA transcripts but no DE lncRNA genes were identified. No DE miRNAs were found. We identified putative regulatory networks likely to be affected by estradiol availability. Changes in gene expression were correlated with changes in body composition variables, indicating that muscularity and adiposity regulators are affected by menopausal transition. We also found correlations between gene expression and physical activity levels.

Conclusions
The observed DE genes and their regulatory networks offer novel mechanistic insights into factors affecting body composition during and after menopause. Our results imply that physiological deteriorations orchestrated by the muscle transcriptome likely depend on the magnitude of hormonal change and are influenced by physical activity.
Design of Human Posture Recognition System Based on Internet of Things Technology and Image Segmentation Algorithm
Authors: Zhao Xinbo , Ding Wei 
Published: March 2024

Abstract
To address the problem of the traditional human posture recognition system being easily affected by environmental factors such as noise, a human posture recognition system based on Internet of Things technology and an image segmentation algorithm was designed. To do this, we selected the attitude sensor, designed the attitude sensor structure based on micro electro mechanical system technology, and had a variety of selectable data output modes. A 36 V power supply was selected as the circuit design index to provide sufficient power for the system. The main control chip was designed, and its state information description and external output were installed in a single chip or the same component. The denoising process based on image segmentation algorithm was designed, the error correction model was constructed, the measured values were normalized, and the image segmentation model was constructed. We extracted the node features of human body posture, used the image segmentation algorithm to construct the structure diagram of human body posture nodes, located the local recognition area of the node structure map, and designed the human body posture recognition system. The experimental results show that the designed human gesture recognition system has better effect and better recognition performance.
Endotracheal Tube Size Adjustments Within Seven Days of Neonatal Intubation
Authors: Peebles Patrick J. , Jensen Erik A. , Herrick Heidi M. , Wildenhain Paul J. , Rumpel Jennifer , Moussa Ahmed , Singh Neetu , Abou Mehrem Ayman , Quek Bin Huey , Wagner Michael , Pouppirt Nicole R. , Glass Kristen M. , Tingay David G. , Hodgson Kate A. , O’Shea Joyce E. , Sawyer Taylor , Brei Brianna K. , Jung Philipp , Unrau Jennifer , Kim Jae H. , Barry James , DeMeo Stephen , Johnston Lindsay C. , Nishisaki Akira , Foglia Elizabeth E. 
Published: March 2024

BACKGROUND AND OBJECTIVES
Neonatal endotracheal tube (ETT) size recommendations are based on limited evidence. We sought to determine data-driven weight-based ETT sizes for infants undergoing tracheal intubation and to compare these with Neonatal Resuscitation Program (NRP) recommendations.

METHODS
Retrospective multicenter cohort study from an international airway registry. We evaluated ETT size changes (downsizing to a smaller ETT during the procedure or upsizing to a larger ETT within 7 days) and risk of procedural adverse outcomes associated with first-attempt ETT size selection when stratifying the cohort into 200 g subgroups.

RESULTS
Of 7293 intubations assessed, the initial ETT was downsized in 5.0% of encounters and upsized within 7 days in 1.5%. ETT downsizing was most common when NRP-recommended sizes were attempted in the following weight subgroups: 1000 to 1199 g with a 3.0 mm (12.6%) and 2000 to 2199 g with a 3.5 mm (17.1%). For infants in these 2 weight subgroups, selection of ETTs 0.5 mm smaller than NRP recommendations was independently associated with lower odds of adverse outcomes compared with NRP-recommended sizes. Among infants weighing 1000 to 1199 g: any tracheal intubation associated event, 20.8% with 2.5 mm versus 21.9% with 3.0 mm (adjusted OR [aOR] 0.62, 95% confidence interval [CI] 0.41–0.94); severe oxygen desaturation, 35.2% with 2.5 mm vs 52.9% with 3.0 mm (aOR 0.53, 95% CI 0.38–0.75). Among infants weighing 2000 to 2199 g: severe oxygen desaturation, 41% with 3.0 mm versus 56% with 3.5mm (aOR 0.55, 95% CI 0.34–0.89).

CONCLUSIONS
For infants weighing 1000 to 1199 g and 2000 to 2199 g, the recommended ETT size was frequently downsized during the procedure, whereas 0.5 mm smaller ETT sizes were associated with fewer adverse events and were rarely upsized.
Şiirsel Bir Arayış Anlatısı Olarak Murathan Mungan'ın Çador'u: “Bir İmaya Dönüşüyor Her Şey”
Authors: Can Gülşen 
Published: March 2024

Yazınsal eserler için türlere ait kuralların esnekleştiği ve eser sahibinin söyleminin önem kazandığı günümüzde, yapıtları belli tür sınıflandırmalarına tabi tutmak, yazınsal türleri kesin çizgilerle ayırmak zorlaşmıştır. Roman, hikâye, şiir gibi türlerin birleşimi konumundaki “mutant metin”ler çoğalmış, yazınsal söylemi belirli bir türe ait çerçeve ile tanımlama gayreti gereklilik olmaktan çıkmıştır. Murathan Mungan’ın Çador eseri de şiir, hikâye, roman, anlatı, mensur şiir şeklinde birbirinden farklı türlerle tanımlanabilir konumdadır. Çador’un tür olarak yaşadığı tanım sorununu aşmak, esere belli bir plan dâhilinde bakabilmek için Mungan’ın eserini konusu, kurgusu, dil ve üslubu ve diğer teknik özellikleriyle “imgesel bir anlatı” olarak tanımlamak mümkündür.
Bu araştırmada, dil bilimi ve gösterge bilimi metotlarından yararlanılarak içerik analizi yöntemi ile Çador anlatısı çözümlenmiş; anlatıların açıklayıcı unsurları olarak özet, konu ve izlek, anlatıcı ve bakış açısı, anlatı kişileri, olay, zaman, mekân, dil ve üslup başlıkları ile metin açımlanmaya çalışılmıştır. Çalışma sonunda, yapıta dair her türlü olgunun sembolik özellik taşıdığı ve ancak zihindeki tasarımlarla anlatı atmosferinin yakalanabileceği görülmüş; şiirsel bir anlatı olan Çador’un başlı başına bir metafor, bir sembol olarak okuyucunun önüne sunulmuş kurmaca bir dünya olduğu ortaya çıkmıştır. Çador, “sıkıştırılmış” ve “ortak-sözceleyen”inin imgesel tasarımına-tamamlamasına sunulmuş kısa sözlerle açılan-derinleşen “yoğun bir anlatı”dır. Murathan Mungan, içerisinde bir “örtü”yü ördüğü ve zihinde açımlanmayınca görülemeyecek-keşfedilemeyecek olan eserinin her bir perdesini aralamayı okuyucusunun ellerine bırakmış durumdadır. İmgelerle örülü bir anlatı olan Çador’un yazınsal olarak incelenmesi, bu örtülü dünyanın az da olsa aydınlatılması amacını taşımaktadır.
Applying Digital Rapid Response Ranking and Event Detection System in Oriente Basin
Authors: Yanez Jorge , Fuenmayor Roberto , Srivastava Prasoon , Sadek Nael , Vivas Pedro 
Published: March 2024

Abstract
During times of uncertainty, upstream producers focus on cost optimization and maximizing net profit bound by the highest safety and environmental impact. They seek the ability to decrease system failure rates, consequently minimizing downtime and lifting costs by extending equipment running life and optimizing operating costs. This paper's main objective is to showcase field results for electric submersible pump (ESP) optimization, ranking, and automatic event detection.
The Oriente Basin is the largest brownfield in Ecuador, from approximately 100 producer wells. Production is achieved from different reservoirs with a high water cut. The artificial lift method selected for these wells is solely ESP. There are several operational challenges; however, the main challenge is to rank the wells that need attention to act upon, to successfully improve the efficiency of operations to maximize productivity and reduce the ESP failure event.
A smart digital system was installed and equipped with trained artificial intelligence and machine learning (AI/ML) to predict a catalog of undesired and critical events and suggest potential actions, to reduce the time of action and avoid production losses and improve the ESPs’ performance indexes; specifically, mean time before failure (MTBF) and failure index (FI).
To achieve these goals, it is necessary to create a digital ecosystem that enables the integration of tools, surveillance, and knowledge. This integration must coincide with the process of going through a digital transformation. The framework includes gathering ESP data frequently, creating a fingerprint for the key ESP problems, understanding how operations conditions vary, and automatically updating the threshold. Opportunities are identified by implementing well thresholds, severity ranking systems, and AI/ML with advanced detection of undesired operating conditions.
Integrating the digital solution, in addition to continuous well review and diagnostics by specialist staff, detected critical ESP events, generated key alarms, and provided communication with the field in the appropriate time and way. Together these resulted in enhancing the ESP run life from 247 days to almost fourfold which is 950 days (about 2 and a half years).
The capacity to combine field knowledge and real-time data enabled with a rapid response AI/ML customized catalog of workflows created the possibility of intelligent actions in the digital field operations by detecting and ranking operational events, creating a focused list of potential failure threats and providing insights of required actions to change course. In conclusion, it reduced the number of ESPs to be shut in every year.