bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Endotracheal Epinephrine on Pharmacokinetics and Survival in a Swine Pediatric Cardiac Arrest Model
Authors: Johnson Don , Hensler Julie G. , O'Sullivan Joseph , Blouin Dawn , de la Garza Melissa A. , Yauger Young 
Published: February 2024

Objectives
The aim of this study was to compare the endotracheal tube (ET) and intravenous (IV) administration of epinephrine relative to concentration maximum, time to maximum concentration, mean concentration over time (MC), area under the curve, odds, and time to return of spontaneous circulation (ROSC) in a normovolemic pediatric cardiac arrest model.

Methods
Male swine weighing 24–37 kg were assigned to 4 groups: ET (n = 8), IV (n = 7), cardiopulmonary resuscitation (CPR) + defibrillation (CPR + Defib) (n = 5), and CPR only (n = 3). Swine were placed arrest for 2 minutes, and then CPR was initiated for 2 minutes. Epinephrine (0.1 mg/kg) for the ET group or 0.01 mg/kg for the IV was administered every 4 minutes or until ROSC. Defibrillation started at 3 minutes and continued every 2 minutes for 30 minutes or until ROSC for all groups except the CPR-only group. Blood samples were collected over a period of 5 minutes.

Results
The MC of plasma epinephrine for the IV group was significantly higher at the 30- and 60-second time points (P = 0.001). The ET group had a significantly higher MC of epinephrine at the 180- and 240-second time points (P < 0.05). The concentration maximum of plasma epinephrine was significantly lower for the ET group (195 ± 32 ng/mL) than for the IV group (428 ± 38 ng/mL) (P = 0.01). The time to maximum concentration was significantly longer for the ET group (145 ± 26 seconds) than for the IV group (42 ± 16 seconds) (P = 0.01). No significant difference existed in area under the curve between the 2 groups (P = 0.62). The odds of ROSC were 7.7 times greater for the ET versus IV group. Time to ROSC was not significantly different among the IV, ET, and CPR + Defib groups (P = 0.31).

Conclusions
Based on the results of this study, the ET route of administration should be considered a first-line intervention.
Bane or boon regarding urbanicity and psychotic spectrum disorders: a scoping review of current evidence
Authors: Chew Qian Hui , Sim Kang 
Published: February 2024

Purpose of review
This review aims to provide an update on the association between urbanization and psychotic spectrum disorders, focusing on specific aspects of the urban environment that could be a bane or boon for the risk of psychosis.

Recent findings
Majority of the included studies support previous evidence suggesting that urbanization is linked to a higher risk of psychotic experiences and psychotic spectrum disorders. A small minority, however, have also found specific factors in the urban environment that could give rise to positive outcomes, such as better social functioning and lower mortality rates in psychotic spectrum disorders, or mitigate the risks associated with urbanization. The perception of the urban environment was also an important factor that increased or mitigated stress levels in patients with psychosis, which in turn affected their susceptibility to psychotic symptoms.

Summary
Specific aspects of the urban environment such as the availability and density of greenspaces are crucial for mitigating the effect of urbanization on risk of psychotic spectrum disorders, and should be incorporated into urban planning. At the same time, there is a need to further explore how modifiable risk factors of the urban environment such as air and noise pollution can be minimized to allow for more liveable cities in the context of psychotic spectrum conditions.
Current perspectives on perinatal mental health and neurobehavioral development: focus on regulation, coregulation and self-regulation
Authors: Van den Bergh Bea R.H. , Antonelli Marta C. , Stein Dan J. 
Published: February 2024

Purpose of review
Perinatal mental health research provides an important perspective on neurobehavioral development. Here, we aim to review the association of maternal perinatal health with offspring neurodevelopment, providing an update on (self-)regulation problems, hypothesized mechanistic pathways, progress and challenges, and implications for mental health.

Recent findings
(1) Meta-analyses confirm that maternal perinatal mental distress is associated with (self-)regulation problems which constitute cognitive, behavioral, and affective social-emotional problems, while exposure to positive parental mental health has a positive impact. However, effect sizes are small. (2) Hypothesized mechanistic pathways underlying this association are complex. Interactive and compensatory mechanisms across developmental time are neglected topics. (3) Progress has been made in multiexposure studies. However, challenges remain and these are shared by clinical, translational and public health sciences. (4) From a mental healthcare perspective, a multidisciplinary and system level approach employing developmentally-sensitive measures and timely treatment of (self-)regulation and coregulation problems in a dyadic caregiver-child and family level approach seems needed. The existing evidence-base is sparse.

Summary
During the perinatal period, addressing vulnerable contexts and building resilient systems may promote neurobehavioral development. A pluralistic approach to research, taking a multidisciplinary approach to theoretical models and empirical investigation needs to be fostered.
Identification of teleosttnnc1aenhancers for specific pan-cardiac transcription
Authors: Bai Jianhui , Wei Xiangyun 
Published: February 2024

AbstractTroponin C regulates muscle contraction by forming the troponin complex with troponin I and troponin T. Different muscle types express different troponin C genes. The mechanisms of such differential transcription are not fully understood. The Zebrafish tnnc1a gene is restrictively expressed in cardiac muscles. We here identify the enhancers and promoters of the zebrafish and medakatnnc1agenes, including intronic enhancers in zebrafish and medaka and an upstream enhancer in the medaka. The intronic and upstream enhancers are likely functionally redundant. The GFP transgenic reporter driven by these enhancers is expressed more strongly in the ventricle than in the atrium, recapitulating the expression pattern of the endogenous zebrafishtnnc1agene. Our study identifies a new set of enhancers for cardiac-specific transgenic expression in zebrafish. These enhancers can serve as tools for future identification of transcription factor networks that drive cardiac-specific gene transcription.
Neighbourhood-level burden of social risk factors on respiratory syncytial virus hospitalization in Ontario, Canada, 2016-2019
Authors: Chen Kitty Y.A. , van Ingen Trevor , Smith Brendan T. , Fitzpatrick Tiffany , Whelan Michael , Parpia Alyssa S. , Alessandrini Jenna , Buchan Sarah A. 
Published: February 2024

AbstractIntroductionBeyond clinical risk factors, little is known about the impact of social determinants on respiratory syncytial virus (RSV) burden. Our study aimed to estimate RSV-related hospitalization rates across sociodemographic and housing characteristics.MethodsWe conducted a population-based study of all RSV-related hospitalizations in Ontario, Canada between September 1, 2016 and August 31, 2019 using validated hospital discharge codes and census data. Crude and age-standardized annualized RSV incidence rates and rate ratios (RR) were estimated for a range of individual-level demographics and neighbourhood-level measures of marginalization and housing characteristics.ResultsOverall, the annual RSV-related hospitalization rate was 27 per 100,000, with the highest rates observed in children <12 months (1049 per 100,000) and 12-23 months (294 per 100,000), and adults ≥85 years (155 per 100,000). Higher RSV-related hospitalization rates were associated with increasing marginalization quintile (Q) of material resources (RR: 1.4; Q5: 33 per 100,000 versus Q1: 24 per 100,000) and household instability (RR: 1.5; Q5: 31 per 100,000 versus Q1: 22 per 100,000).ConclusionThe burden of RSV-related hospitalization was greatest in young children and older adults, with variation by sociodemographic and housing factors. Understanding the role of these social factors is crucial for informing equitable preventive program delivery.
Essential functions of Inositol hexakisphosphate (IP6) in Murine Leukemia Virus replication
Authors: Biswas Banhi , Lai Kin Kui , Bracey Harrison , Datta Siddhartha A.K. , Harvin Demetria , Sowd Gregory A. , Aiken Christopher , Rein Alan 
Published: February 2024

SUMMARYWe have investigated the function of inositol hexakisphosphate (IP6) and inositol pentakisphosphate (IP5) in the replication of murine leukemia virus (MLV). While IP6 is known to be critical for the life cycle of HIV-1, its significance in MLV remains unexplored. We find that IP6 is indeed important for MLV replication. It significantly enhances endogenous reverse transcription (ERT) in MLV. Additionally, a pelleting-based assay reveals that IP6 can stabilize MLV cores, thereby facilitating ERT. We find that IP5 and IP6 are packaged in MLV particles. However, unlike HIV-1, MLV depends upon the presence of IP6 and IP5 in target cells for successful infection. This IP6/5 requirement for infection is reflected in impaired reverse transcription observed in IP6/5-deficient cell lines. In summary, our findings demonstrate the importance of capsid stabilization by IP6/5 in the replication of diverse retroviruses; we suggest possible reasons for the differences from HIV-1 that we observed in MLV.
Searching for new physics at
μ→e
facilities with
μ+
and
π+
decays at rest
Authors: Hill Richard J. , Plestid Ryan , Zupan Jure 
Published: February 2024

We investigate the ability of μ→e facilities, Mu2e and COMET, to probe, or discover, new physics with their detector validation datasets. The validation of the detector response may be performed using a dedicated run with μ+, collecting data below the Michel edge, Ee≲52  MeV; an alternative strategy using π+→e+νe may also be considered. We focus primarily on a search for a monoenergetic e+ produced via two-body decays μ+→e+X or π+→e+X, with X a light new physics particle. Mu2e can potentially explore new parameter space beyond present astrophysical and laboratory constraints for a set of well motivated models including axionlike particles with flavor violating couplings (μ+→e+a), massive Z′ bosons (μ+→Z′e+), and heavy neutral leptons (π+→e+N). The projected sensitivities presented herein can be achieved in a matter of days.

Published by the American Physical Society
2024
Detecting nitrogen-vacancy-hydrogen centers on the nanoscale using nitrogen-vacancy centers in diamond
Authors: Findler Christoph , Blinder Rémi , Schüle Karolina , Balasubramanian Priyadharshini , Osterkamp Christian , Jelezko Fedor 
Published: February 2024

In diamond, nitrogen defects like the substitutional nitrogen defect (Ns) or the nitrogen-vacancy-hydrogen complex (NVH) outnumber the nitrogen-vacancy (NV) defect by at least one order of magnitude creating a dense spin bath. While neutral Ns has an impact on the coherence of the NV spin state, the atomic structure of NVH reminds of a NV center decorated with a hydrogen atom. As a consequence, the formation of NVH centers could compete with that of NV centers possibly lowering the N-to-NV conversion efficiency in diamond grown with hydrogen-plasma-assisted chemical vapor deposition (CVD). Therefore, monitoring and controlling the spin bath is essential to produce and understand engineered diamond material with high NV concentrations for quantum applications. While the incorporation of Ns in diamond has been investigated on the nano- and mesoscale for years, studies concerning the influence of CVD parameters and the crystal orientation on the NVH formation have been restricted to bulk N-doped diamond providing high-enough spin numbers for electron paramagnetic resonance and optical absorption spectroscopy techniques. Here, we investigate submicron-thick (100)-diamond layers with nitrogen contents of (13.8±1.6)ppm and (16.7±3.6)ppm, and exploiting the NV centers in the layers as local nanosensors, we demonstrate the detection of NVH− centers using double electron-electron resonance (DEER). To determine the NVH− densities, we quantitatively fit the hyperfine structure of NVH− and confirm the results with the DEER method usually used for determining Ns0 densities. With our experiments, we access the spin bath composition on the nanoscale and enable a fast feedback loop in CVD recipe optimization with thin diamond layers instead of resource- and time-intensive bulk crystals. Furthermore, the quantification of NVH− plays a very important role for understanding the dynamics of vacancies and the incorporation of hydrogen into CVD diamond optimized for quantum technologies.

Published by the American Physical Society
2024
How do projects decouple from coercive pressures? A study of decoupling in construction projects
Authors: Zomer Thayla , Neely Andy , Savaget Paulo 
Published: February 2024

PurposeHow organisations interact with and respond to environmental pressures has been a long-term interest of organisational scholars. Still, it remains an under-theorised phenomenon from a project perspective. So far, there is limited understanding of how projects, which are composed by a constellation of organisations, “respond” to institutional pressures that are exerted on them. This research takes the perspective of projects as adopters/implementers of institutional pressures and analyses how they interact with, and respond to, such pressures. More specifically, this research explores how construction projects respond to the pressure of a Building Information Modelling (BIM) mandate.Design/methodology/approachMultiple in-depth case studies were conducted to explore the practical implementation of a BIM mandate in the UK and understand how the construction projects responded to the coercive pressures to implement a new policy mandate for process digitalisation. Multiple sources were employed for data collection and the data were analysed inductively. The findings identify a hybrid response comprising four distinct ways that projects might respond to an institutional pressure.FindingsWe find that projects decouple both from the content and from the intended purpose of a policy, i.e. there are two variance of a policy-practice decoupling phenomenon in projects. The findings also reveal the underlying conditions leading to decoupling.Originality/valueWe advance decoupling literature so that it better applies to the temporary, distributed and interdependent work conducted via projects. Second, we define decoupling in projects as a provisional and fragmented process of wayfinding through heterogeneous institutional spaces, and discuss the potential policy-practice assemblages in projects, influenced by how, if and when project members' activities decouple from the many and often contradicting institutional pressures they face. Third, we discuss how the qualitatively different forms of decoupling that we identified in our work may act as part of a legitimation process in ambiguous situations whereby projects might share a resemblance of conformity with institutional pressures when they are de facto only partially conforming to them.
The effect of gender diversity on the disclosure of key audit matters: examination of dual-signature environment
Authors: He Li Jen , Rivai Faradillah Amalia 
Published: February 2024

Purpose
This paper aims to investigate the impact of gender diversity in the composition of engagement auditors on the disclosure of key audit matters (KAMs) in a dual-signature environment.

Design/methodology/approach
The authors used the unique institutional setup of Taiwan, where the law requires that audit reports be signed by two audit partners. The authors examined the effect of gender diversity composition among engagement auditors on KAM disclosure, considering behavioral differences between female and male auditors.

Findings
The empirical results indicate that gender diversity composition in the dual-signature environment is associated with the number of disclosed KAM items (KAMIT) and the length of the explanations for each KAMIT. Furthermore, the authors found that gender diversity composition, particularly when led by female audit partners, has a more pronounced impact on the explanation of each KAMIT rather than on the disclosure of KAMIT. The authors also noted that the moderating effect of audit firm specialization does not influence the gender diversity composition of audit partners in disclosing KAMs.

Originality/value
This study’s empirical findings demonstrate that the interaction between different gender compositions in a dual-signature environment influences KAM disclosure.
Evaluating the effectiveness of trauma-informed care training delivered to staff in community Older Adult Mental Health Services
Authors: Russell Katie , Moghaddam Nima , Tickle Anna , Campion Gina , Cobley Christine , Page Stephanie , Langthorne Paul 
Published: February 2024

Purpose
By older adulthood, the majority of individuals will have experienced at least one traumatic event. Trauma-informed care (TIC) is proposed to improve effectivity of health-care provision and to reduce likelihood of services causing retraumatisation. This study aims to assess the effectiveness of staff training in TIC in older adult services.

Design/methodology/approach
TIC training was delivered across eight Older Adult Community Mental Health Teams in the same UK organisation. Questionnaires were administered before and after training: a psychometrically robust measure, the Attitudes Related to Trauma-Informed Care, was used to assess TIC-related attitudes, and a service-developed scale was used to measure changes in TIC competence. Data was analysed using linear mixed effects modelling (LMM). Qualitative data regarding the impact of training was gathered one month after training through a free-text questionnaire.

Findings
There were 45 participants, all of whom were white British. LMM on pre- and post-data revealed that staff training significantly increased competencies across all measured TIC domains. Overall, staff attitudes were also significantly more trauma-informed after training. Qualitatively, staff identified time as the only additional resource required to deliver the skills and knowledge gained from training.

Practical implications
Training was found to be effective in increasing TIC-related skills and attitudes. Organisations aiming to become trauma-informed should consider staff training as one aspect of a wider development plan.

Originality/value
To the best of the authors’ knowledge, this paper is the first to examine TIC training for staff working in Older Adults Mental Health Services. Recommendations for services aiming to develop a trauma-informed culture have been provided.
Priority and non-priority sector GNPAS in Indian commercial banks: a comparison between sub-sectors
Authors: Kanyan Kavita , Singh Shveta 
Published: February 2024

Purpose
This study aims to examine the impact and contribution of priority and non-priority sectors, as well as their sub-sectors, on the gross non-performing assets of public, private and foreign sector banks.

Design/methodology/approach
The Reserve Bank of India's database on the Indian economy is used to retrieve data over 13 years (2008–2021). Public sector (12), private sector (22) and foreign sector (44) banks are represented in the sample. Two-way ANOVA, multiple regression and panel regression statistical techniques are used in SPSS and EViews to examine the data. Further, the results are also validated by using robustness testing by applying the fully modified ordinary least square (FMOLS) and dynamic least square (DOLS) regression.

Findings
The results showed that, for private and foreign banks, the non-priority sector makes up the majority of the total gross non-performing assets, although both the priority and non-priority sectors are substantial for public sector banks. The largest contributors to the total gross non-performing assets in public, private and foreign banks are industries, agriculture and micro and small businesses. The FMOLS displays robustness results that are qualitatively similar to the baseline result.

Practical implications
Based on the study's findings about the patterns of non-performing assets originating from these specific industries, banks might improve the way in which these advanced loans are managed.

Originality/value
There has not been much research done on the subject of sub-sector-specific non-performing assets and how they affect total gross non-performing assets across the three sector banks. The study's primary focus will be on the issue of non-performing assets in the priority’s and non-priority’s sub-sectors, namely, agricultural, micro and small businesses, food credit, industries, services, retail loans and other priority and non-priority sectors.
Association between filaggrin gene mutations and the clinical features of molluscum contagiosum: The Yamanashi Adjunct Study of the Japan Environment and Children's Study
Authors: Kojima Reiji , Miyake Kunio , Shinohara Ryoji , Kushima Megumi , Yui Hideki , Otawa Sanae , Horiuchi Sayaka , Yokomichi Hiroshi , Akiyama Yuka , Ooka Tadao , Yamagata Zentaro ,   the Yamanashi Adjunct Study of the Japan Environment and Children's Study Group
Published: February 2024

AbstractPrevious studies have reported swimming, atopic dermatitis, and filaggrin (FLG) gene mutations as risk factors for molluscum contagiosum (MC) infection. FLG gene mutations impair skin barrier function. The aim of this study was to determine the impact of FLG mutations on the incidence and clinical features of MC. We used data from 2036 children who participated in the Yamanashi Adjunct Study of the Japan Environment and Children's Study, a prospective, birth cohort study. A questionnaire for caregivers (when children were 4 and 8 years of age) asked about clinical features including previous MC incidence and treatment, number of MC lesions at first visit, and time to resolution. Participants underwent genotyping to detect six FLG mutations that are common in the Japanese population. A logistic regression model was used to analyze the association between MC incidence and FLG mutations, adjusted for potential confounders. The cumulative incidence of MC at age 8 years was 47.1%. Among participants with a history of MC, 67.6% had undergone curettage. FLG mutation was a significant risk factor for MC incidence (adjusted odds ratio [aOR] 1.69, 95% confidence interval [CI] 1.18–2.42). Swimming and atopic dermatitis were also significant risk factors for MC. There was no significant association between FLG mutation and the number of MC lesions at the first visit or the time to resolution of lesions. FLG mutation is a risk factor for MC incidence; however, FLG mutations do not affect the number of MC lesions at presentation or the time to resolution.