bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin D3 among neonates born after in vitro fertilization compared with neonates from the general population
Authors: Walker Karen Christina , Pristed Sofie Gry , Thorsteinsdottir Fanney , Specht Ina Olmer , Cohen Arieh , Heitmann Berit Lilienthal , Kesmodel Ulrik Schiøler 
Published: April 2024

AbstractIntroductionSufficient levels of vitamin D have been associated with higher chances for both clinical pregnancy and live birth among women undergoing assisted reproductive techniques, whereas low levels of maternal vitamin D have been associated with preeclampsia and late miscarriage. In Denmark, subgroups at risk for low vitamin D levels, including neonates and toddlers, are recommended to use supplementation. The aim was to study the level of vitamin D3 among neonates born after in vitro fertilization compared with neonates from the general population.Material and methodsIn this cohort study a random sample of 1326 neonates representing the general population and 1200 neonates conceived by in vitro fertilization born in Denmark from 1995 to 2002 were identified from registries covering the whole Danish population. Information on use of assisted reproduction was collected from the Danish In Vitro Fertilization register, ICD‐10 code: DZ358F. 25‐Hydroxyvitamin D was measured from dried blood spots routinely collected by heel prick 48–72 h after birth and corrected according to the hematocrit fraction for capillary blood of neonates. Linear regression analysis was performed, both crude and adjusted, for predefined putative confounders, identified through directed acyclic graphs.ResultsVitamin D3 analysis could be performed from a total of 1105 neonates from the general population and 1072 neonates conceived by in vitro fertilization that were subsequently included in the study. The median vitamin D3 was 24.0 nmol/L (interquartile range [IQR] 14.1–39.3) and 33.0 nmol/L (IQR 21.3–48.8) among neonates from the general population and neonates conceived by in vitro fertilization, respectively. The adjusted mean difference between neonates from the general population and those conceived by in vitro fertilization was 6.1 nmol/L (95% confidence interval 4.1–8.1).ConclusionsIn this study, children born after in vitro fertilization have a higher vitamin D3 than a random sample of neonates in Denmark.
Phenomenology and empowerment in self‐testing apps
Authors: Kapeller Alexandra 
Published: April 2024

AbstractAlthough self‐testing apps, a form of mobile health (mHealth) apps, are often marketed as empowering, it is not obvious how exactly they can empower their users—and in which sense of the word. In this article, I discuss two conceptualisations of empowerment as polar opposites—one in health promotion/mHealth and one in feminist theory—and demonstrate how both their applications to individually used self‐testing apps run into problems. The first, prevalent in health promotion and mHealth, focuses on internal states and understands empowerment as an individual process. However, this version of empowerment has been accused of paternalism and responsibilisation. The second, feminist version considers structural conditions and foregrounds collective, political change, whose realisation is not obviously attainable for an individually used app. By pointing out the flaws of the positions that focus on either internal states or external conditions, and by engaging with theory from critical phenomenology, I argue that the interplay between them is where empowerment can take place. I propose to formulate empowerment in phenomenological terms as a shift in being‐in‐the‐world and discuss how this conceptualisation of empowerment would avoid the criticism of previous empowerment narratives while being realisable by self‐testing apps.
Efficacy of ruxolitinib in the treatment of relapsed/refractory large granular lymphocytic leukaemia
Authors: Marchand Tony , Pastoret Cédric , Damaj Gandhi , Lebouvier Angélique , Herbaux Charles , Moignet Aline , Pavlosky Miguel , Pavlosky Astrid , Blouet Anaise , Eloit Martin , Launay Vincent , Lebreton Pierre , Stamatoullas Aspasia , Nilsson Christer , Ochmann Marlène , Prola Juliette , Lamy Thierry 
Published: April 2024

SummaryLarge granular lymphocytic (LGL) leukaemia is a rare chronic lymphoproliferative disorder characterized by an expansion of cytotoxic T or NK cells. Despite a usually indolent evolution, most patients will require a treatment over the course of the disease because of cytopenia or symptomatic associated autoimmune disorders. First‐line treatment is based on immunosuppressive agents, namely cyclophosphamide, methotrexate and ciclosporin. However, relapses are frequent, and there is no consensus on the management of relapsed/refractory patients. The implication of the JAK/STAT pathway in the pathogenesis of this disease has prompted our group to propose treatment with ruxolitinib. A series of 21 patients who received this regimen is reported here. Ten patients (47.6%) were refractory to the three main immunosuppressive drugs at the time of ruxolitinib initiation. Ruxolitinib yielded an overall response rate of 86% (n = 18/21), including 3 complete responses and 15 partial responses. With a median follow‐up of 9 months, the median response duration was 4 months. One‐year event‐free survival and 1‐year overall survival were 57% and 83% respectively. Mild side effects were observed. Biological parameters, notably neutropenia and anaemia, improved significantly, and complete molecular responses were evidenced. This study supports ruxolitinib as a valid option for the treatment of relapsed/refractory LGL leukaemia.
Enhancing the SUSTAINable uptake of evidence to minimise harms from alcohol and other drugs in New South Wales, Australia
Authors: Farnbach Sara , Foley Catherine , Gates Peter , Seccull Alison , Henderson Alexandra , Zocco Andrea , Farrell Michael , Shakeshaft Anthony 
Published: April 2024

AbstractAlthough alcohol and other drug use is increasingly the focus of policy and research efforts, there are challenges identifying and applying evidence‐based strategies to minimise harms for alcohol and other drugs in health care and community settings. These challenges include limited available research, variability across settings, and lack of ‘fit’ between research evidence and their intended settings. In this commentary, we describe a novel approach to develop and evaluate tailored, sustainable strategies to enhance the uptake of evidence‐based activities into health services and community settings. Our approach involves four key principles: (i) identifying evidence‐based alcohol and other drug harm minimisation strategies; (ii) partnering with local experts to identify and tailor strategies; (iii) implementing strategies into existing practice/infrastructure to build in sustainability; and (iv) using sustainable co‐designed outcome measures including value‐based health‐care principles to measure uptake, feasibility and acceptability, health outcomes and economic implications. We propose that this approach offers a way forward to enhance the relevance and suitability of research in health services and community settings and has potential to be applied in other sectors.
Alcohol screening in 22 Australian Aboriginal Community Controlled Health Organisations: Clinical context and who is screened
Authors: Weatherall Teagan J. , Conigrave James H. , Lee K. S. Kylie , Vnuk Julia , Ivers Rowena , Hayman Noel , Wilson Scott , Gray Dennis , Conigrave Katherine M. 
Published: April 2024

AbstractIntroductionAlcohol screening among Indigenous Australians is important to identify individuals needing support to reduce their drinking. Understanding clinical contexts in which clients are screened, and which clients are more or less likely to be screened, could help identify areas of services and communities that might benefit from increased screening.MethodsWe analysed routinely collected data from 22 Aboriginal Community Controlled Health Organisations Australia‐wide. Data collected between February 2016 and February 2021 were analysed using R, and aggregated to describe screening activity per client, within 2‐monthly extraction periods. Descriptive analyses were performed to identify contexts in which clients received an Alcohol Use Disorders Identification Test consumption (AUDIT‐C) screen. Multi‐level logistic regression determined demographic factors associated with receiving an AUDIT‐C screen. Three models are presented to examine if screening was predicted by: (i) age; (ii) age and gender; (iii) age, gender and service remoteness.ResultsWe observed 83,931 occasions where AUDIT‐C was performed at least once during a 2‐monthly extraction period. Most common contexts were adult health check (55.0%), followed by pre‐consult examination (18.4%) and standalone item (9.9%). For every 10 years' increase in client age, odds of being screened with AUDIT‐C slightly decreased (odds ratio 0.98; 95% confidence interval [CI] 0.98, 0.99). Women were less likely to be screened with AUDIT‐C (odds ratio 0.95; 95% CI 0.93, 0.96) than men.Discussion and ConclusionsThis study identified areas where alcohol screening can be increased (e.g., among women). Increasing AUDIT‐C screening across entire communities could help reduce or prevent alcohol‐related harms. Future Indigenous‐led research could help identify strategies to increase screening rates.
Pharmacological and neurosurgical management of cerebral palsy and dystonia: Clinical practice guideline update
Authors: Fehlings Darcy , Agnew Brenda , Gimeno Hortensia , Harvey Adrienne , Himmelmann Kate , Lin Jean‐Pierre , Mink Jonathan W. , Monbaliu Elegast , Rice James , Bohn Emma , Falck‐Ytter Yngve 
Published: April 2024

AbstractDystonia, typically characterized by slow repetitive involuntary movements, stiff abnormal postures, and hypertonia, is common among individuals with cerebral palsy (CP). Dystonia can interfere with activities and have considerable impact on motor function, pain/comfort, and ease of caregiving. Although pharmacological and neurosurgical approaches are used clinically in individuals with CP and dystonia that is causing interference, evidence to support these options is limited. This clinical practice guideline update comprises 10 evidence‐based recommendations on the use of pharmacological and neurosurgical interventions for individuals with CP and dystonia causing interference, developed by an international expert panel following the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. The recommendations are intended to help inform clinicians in their use of these management options for individuals with CP and dystonia, and to guide a shared decision‐making process in selecting a management approach that is aligned with the individual's and the family's values and preferences.
Settler aesthetics—Theorizing and contesting settler colonialism through art practice
Authors: Malot J. Zoe 
Published: April 2024

AbstractThe growing scholarship on settler colonialism largely understudies aesthetics. Settler colonial logics work not only through the elimination, dispossession, and criminalization of Indigenous populations but also through the erasure of Indigenous narratives and aesthetics. Aesthetics communicate a particular system of knowledge and power that can either refute or perpetuate settler colonial projects. I use the term “settler aesthetics” to foreground an understanding of aesthetics as dynamic socio‐spatial practices through which state and non‐state actors assert power, construct particular visions of a city, and shape conditions of belonging. Settler aesthetics demonstrate how the logic of elimination and the work of settler memory reproduces and is reproduced through various visual modalities. I argue that as geographers, we must examine both contemporary settler colonial projects that continue codifying cities as purely settler spaces without Indigenous presence and resistance, and spaces that insist on Black, Latinx, and Indigenous presence and livingness. This paper therefore explores how scholarship on decolonizing and anti‐colonial art practice and theory can inform emerging scholarship on settler colonial urbanism that centers perspectives and practices of Black and Indigenous presence and resistance.
Impact of various aging treatments on the microhardness and surface roughness of CAD‐CAM monolithic restorative materials
Authors: Deste Gökay Gonca , Oyar Perihan , Durkan Rukiye 
Published: April 2024

AbstractPurposeDental ceramics deteriorate as a result of thermal aging and exposure to acidic solutions, which change their microhardness and surface roughness. This study assessed the resistance of several computer‐aided design and computer‐aided manufacturing (CAD‐CAM) restorative dental materials in terms of surface roughness and microhardness following exposure to acidic solutions and thermal aging.Materials and MethodsFive different monolithic CAD‐CAM restorative materials, two leucite‐reinforced glass ceramics (G‐Ceram and CEREC Blocs), a zirconia‐infiltrated lithium silicate (Celtra Duo), a resin nanoceramic (Grandio), and monolithic zirconia (inCoris TZI), were used to create 2‐mm‐thick rectangular specimens (n = 100). After being immersed in either acidic saliva (pH = 4.0) (ST) or gastric juice (pH = 1.2) (GT), each material was subjected to 10,000 cycles of thermal aging. The Vickers microhardness and average surface roughness of the specimens were assessed at baseline, following thermal aging and exposure to either gastric juice or acidic saliva. The surface properties were examined using an atomic force microscope. The Mann‒Whitney U test with Bonferroni correction and the Wilcoxon signed‐rank test was used for statistical analysis (a = 0.05).ResultsThe surface roughness of two leucite‐reinforced glass ceramics (G‐ceram and CEREC) significantly decreased with ST (p = 0.027 and p = 0.044). Only the CEREC was affected when the aging protocols were compared, and the ST group had a significant reduction in roughness (p = 0.009). The microhardness values significantly decreased after both aging protocols in all groups except for the ST subgroup of G‐Ceram. Only inCoris was affected when the aging protocols were compared, and the GT group exhibited a significant reduction in microhardness (p = 0.002).ConclusionThe surface roughness of the tested materials was not affected by the GT. Only leucite ceramics exhibited a decrease in surface roughness in the ST stage. Both aging processes produced a significant decrease in the microhardness of the tested ceramics. Leucite‐reinforced glass‐ceramic materials may be advantageous for patients with gastroesophageal reflux disease and those with a diet high in acidic foods due to their lower values for changes in microhardness and surface roughness compared to those of other CAD‐CAM materials.
Playing the political game of innovation: An integrative framework and future research directions
Authors: Schweitzer Fiona , Röth Tobias , Birkinshaw Julian , Barczak Gloria 
Published: April 2024

AbstractInnovation politics impact the development and introduction of innovations, yet knowledge about the influence of specific political behavior or behavioral patterns remains blurred. Based on a literature review and the articles in this Special Issue, we propose a three‐part framework that identifies the building blocks of political behavior in innovation: what motivates actors to be political, the different types of political actors, and the effect of various political behaviors on innovation outcomes. Emphasizing the evolving landscape of innovation politics, the framework aims to highlight research gaps and guide future studies toward improving our understanding of the functional and dysfunctional aspects of innovation politics.
Attitudes toward fraudulent behavior and the decision to file first‐party and third‐party bodily injury auto insurance claims
Authors: Kerr Dana A. 
Published: April 2024

AbstractThis research explores the presence of ex post moral hazard in auto insurance claim filing decisions by determining the relationship between attitudes toward fraudulent behavior and the decisions by those injured in auto accidents to file bodily injury auto insurance claims. Of particular interest is the effect of these attitudes on the propensity to file first‐party bodily injury auto insurance claims, which has not been specifically identified in earlier studies. A multinomial logistic regression model is used to take advantage of survey data that directly capture the first‐ and third‐party auto insurance claim filing decisions for bodily injuries suffered in auto accidents across the United States between 1995 and 1998. The results indicate that, in addition to third‐party claims, ex post moral hazard is present in first‐party bodily injury auto insurance claim filing decisions as well despite possible differences in the incentives to commit first‐party and third‐party insurance fraud.
Difficult past, cultural trauma and national identity: The commemorations of the Armenian Genocide in Istanbul
Authors: Salomoni Fabio 
Published: April 2024

AbstractIn Turkey, for at least three decades, a plurality of actors has been producing counter narratives of the Armenian Genocide. These have challenged the official discourse, revealing the old taboo that underpinned the national republican identity and reconceiving it as a contested history that interrogates the country's democratic status. Here, it is argued that this recent history of counter narratives has constituted a trauma process aimed at transforming public memory and national identity. In particular, various commemoration ceremonies were held in Istanbul between 2005 and 2023, with counter ceremonies and a revised official narrative expressed through ceremony that was developed in response. Given that these commemorations occupy a marginal space in the literature on the Armenian question and the Genocide, the first aim of this article is to reconstruct them through the perspective of cultural performance. Then, it is argued that the commemorations not only have an opaque status in the cultural trauma literature but also contribute to the trauma process through their creation of specific trauma narratives of the Genocide. Finally, the paper uses the example of commemorative performances in Istanbul to contribute to the debate on the reasons for the success or failure of a trauma process. Methodologically, an analysis of journal archives and materials produced by carrier groups is extended by ten in‐depth interviews and notes taken during participant observation in Istanbul between 2010 and 2022.
A two‐step estimation procedure for semiparametric mixture cure models
Authors: Musta Eni , Patilea Valentin , Van Keilegom Ingrid 
Published: April 2024

AbstractIn survival analysis, cure models have been developed to account for the presence of cured subjects that will never experience the event of interest. Mixture cure models with a parametric model for the incidence and a semiparametric model for the survival of the susceptibles are particularly common in practice. Because of the latent cure status, maximum likelihood estimation is performed via the iterative EM algorithm. Here, we focus on the cure probabilities and propose a two‐step procedure to improve upon the maximum likelihood estimator when the sample size is not large. The new method is based on presmoothing by first constructing a nonparametric estimator and then projecting it on the desired parametric class. We investigate the theoretical properties of the resulting estimator and show through an extensive simulation study for the logistic‐Cox model that it outperforms the existing method. Practical use of the method is illustrated through two melanoma datasets.
Ensuring a sustained workforce to combat antibiotic resistance in the 21st century: the critical need for training the next-gen of scientists at the pre-doctoral level
Authors: Shafer William M. , Conn Graeme L. 
Published: April 2024

ABSTRACT

Antibiotics revolutionized the treatment of bacterial infection and enhanced modern healthcare. While the current global antibiotic resistance crisis is widely acknowledged, the need for a highly trained cohort of scientists to continue and expand efforts to combat this threat has received less attention. We posit that training of pre-doctoral students in the antibiotic resistance field is critical for future efforts in combating this crisis and urge development of training programs that focus on this need.
Expanding the adenovirus toolbox: reporter viruses for studying the dynamics of human adenovirus replication
Authors: King Cason R. , Dodge Mackenzie J. , MacNeil Katelyn M. , Tessier Tanner M. , Mymryk Joe S. , Mehle Andrew 
Published: April 2024

ABSTRACT

To streamline standard virological assays, we developed a suite of nine fluorescent or bioluminescent replication competent human species C5 adenovirus reporter viruses that mimic their parental wild-type counterpart. These reporter viruses provide a rapid and quantitative readout of various aspects of viral infection and replication based on EGFP, mCherry, or NanoLuc measurement. Moreover, they permit real-time non-invasive measures of viral load, replication dynamics, and infection kinetics over the entire course of infection, allowing measurements that were not previously possible. This suite of replication competent reporter viruses increases the ease, speed, and adaptability of standard assays and has the potential to accelerate multiple areas of human adenovirus research.

IMPORTANCE
In this work, we developed a versatile toolbox of nine HAdV-C5 reporter viruses and validated their functions in cell culture. These reporter viruses provide a rapid and quantitative readout of various aspects of viral infection and replication based on EGFP, mCherry, or NanoLuc measurement. The utility of these reporter viruses could also be extended for use in 3D cell culture, organoids, live cell imaging, or animal models, and provides a conceptual framework for the development of new reporter viruses representing other clinically relevant HAdV species.