bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment and Decision‐Making Preferences of Adolescents and Young Adults With Advanced Cancer and Their Parents or Trusted Persons: An Adaptive Conjoint Analysis Study
Authors: Snaman Jennifer M. , Feifer Deborah , Helton Gabrielle , Herold Benjamin , Chen Li , Mazzola Emanuele , Rosenberg Abby R. , Baker Justin N. , Wolfe Joanne 
Published: February 2025

ABSTRACTPurposeTreatment decision‐making in adolescents and young adults (AYAs) requires preference consideration and tradeoffs. Using MyPref, an adaptive conjoint analysis tool, we examined and compared the decision‐making and treatment preferences of both AYAs and their parent or other trusted person (PTP).Patients and MethodsAYAs aged 15–30 with advanced cancer independently completed MyPref, including demographic questions, the Control Preference Scale, and the adaptive conjoint analysis survey. AYAs could invite a PTP to participate. Participants received a personalized MyPref Summary Report quantifying their preference for nine treatment attributes. Preference scores were summarized and compared by participant group, AYA age, sex, cancer diagnosis, and distance from the hospital.ResultsWe enrolled 50 AYAs, 15 of whom selected a PTP to participate. Most AYAs identified as male (64%), White, non‐Hispanic (84%), and had solid tumors (48%). The majority (80%) of PTPs identified as the AYA's mother. AYAs favored participant‐led decision‐making, while PTPs preferred a shared approach. Treatment attributes with the highest preference scores included time until cancer grows, quality of life, and side effects. Compared to PTPs, AYAs had lower preference scores for quality of life. Older AYAs ( years) placed more emphasis on the time until cancer grows, whereas younger AYAs prioritized clinic visit frequency.ConclusionAYAs with advanced cancer exhibit diverse preferences for decision‐making roles and treatment factors. Despite differences, participants valued longer time until cancer progression and quality of life. Future research should explore how preferences of AYAs and their PTPs change over time and optimal strategies for initiating preference discussions earlier in the illness course.
Impact of basalt powder on the rheological, thermal, mechanical, and tribological properties of natural and polychloroprene rubber composites: A study on aging and filler interaction
Authors: Yildiz Enes , Degirmenci Talha , Esen Melih , Goksuzoglu Mert , Kuru Gozde , Eskizeybek Volkan , Sukur Emine Feyza 
Published: February 2025

AbstractThis study investigates the effects of basalt powder (BP) as a filler in natural rubber (NR) and synthetic polychloroprene rubber (CR) composites, focusing on their structural, mechanical, and thermal properties before and after aging. The NR/BP and CR/BP composites were prepared with varying basalt content levels of 0, 5, 10, 15, 50, and 100 parts per hundred rubber (phr) and characterized accordingly. Mechanical properties such as tensile strength, Young's modulus, and abrasion resistance were evaluated, alongside thermal properties, using thermogravimetric analysis. The results showed that increasing the basalt content reduced dispersion quality and weakened the filler and matrix interaction, decreasing tensile strength and Young's modulus. The reduction in tensile strength is substantial, with a decrease of 71.7% in NR/BP composites and 64.1% in CR/BP composites at maximum additive ratios. Aging significantly improved the tensile strength and modulus of the materials, which are attributed to an increased crosslink density and the transformation of polysulfide bonds into disulfide bonds. Shore A hardness increased with basalt content, reaching 60.3 for NR/BP and 74.1 for CR/BP at 100 phr, while abrasion resistance decreased, with abrasion loss rising by 130% and 88% for NR/BP and CR/BP composites, respectively. Scanning electron microscopy (SEM) analysis revealed increased surface roughness and filler aggregation at higher basalt contents, contributing to reduced mechanical performance. Fourier‐transform infrared spectroscopy (FTIR) and energy‐dispersive X‐ray spectroscopy (EDX) analyses confirmed the presence and dispersion of basalt powder within the composites.Highlights
Basalt powder was evaluated as a filler in natural and synthetic rubber composites.
Increasing basalt content reduced mechanical performance due to filler aggregation.
Aging enhances tensile strength and modulus, possibly due to increased crosslink density.
Abrasion resistance significantly worsened with increased basalt loading.
Basalt powder serves the function of a filler rather than that of reinforcement in rubber.
Motivation and Pleasure Domain Links to Social Function in College Students: A Network Analysis
Authors: Hu Hui‐xin , Wang Ling‐ling , Zhang Yi‐Jing , Yang Han‐xue , Wang Yun‐ru , Wang Yi , Lui Simon S. Y. , Chan Raymond C. K. 
Published: February 2025

ABSTRACTEvidence suggests that the motivation and pleasure deficit of negative symptoms determines the social functioning in patients with schizophrenia spectrum disorder. Alexithymia is defined as the diminished ability to identify and describe emotion feelings, and influences patients' social functioning. However, little is known regarding the relationship between motivation and pleasure, alexithymia, and social functioning in nonclinical populations. This network analysis study aimed to investigate the interactions between motivation and pleasure, alexithymia and social functioning in a sample of 2889 college students. The flow network and item‐level regularized partial correlation network were constructed. Centrality estimation and relative importance metrics were also estimated. The network structures between subgroups with high and low social anhedonia were compared. Our resultant networks showed that the motivation factor was closely connected with social functioning. The relative importance analysis found that, among other nodes, the motivation factor accounted for the highest proportion of variance of social functioning in the nonclinical sample. Although the two subgroups with high and low social anhedonia differed significantly in network structures, they generally shared a similar edge structure. The two subgroups only exhibited significant difference in the connection between the social pleasure factor and recreation/work pleasure factor of the motivation and pleasure. Our findings supported the important role of the motivation factor in determining social functioning in nonclinical population.
Self‐reported sleep disturbances and its determinants in people 1 year or more after stroke: A cross‐sectional study
Authors: Nilsson Hanna M. , Kähler Maria , Rosengren Lina , Jacobsson Lars , Lexell Jan 
Published: February 2025

AbstractBackgroundSurvivors of stroke commonly report sleep disturbances. Studies of sleep disturbances after stroke are mostly performed in the acute phase. An increased knowledge of sleep disturbances and its determinants a longer time after stroke is needed to improve treatment and rehabilitation.ObjectiveTo assess survivors of stroke more than 1 year after stroke onset and (1) investigate self‐reported sleep disturbances and (2) explore the association between self‐reported sleep disturbances, gender, age, time since stroke, other stroke characteristics, and sociodemographic data.DesignCross‐sectional survey.SettingCommunity setting.ParticipantsParticipants (n = 160) in the Life After Stroke In Northern Sweden Study (LASINS) (46% women, mean age 73 years, mean time since stroke 35 months).InterventionsNot applicable.Main Outcome MeasurementsPittsburgh Sleep Quality Index (PSQI), stroke characteristics (time since stroke, first time stroke, type of stroke, location of stroke, stroke treatment and comorbidities) and sociodemographic data (gender, age, marital status, vocational situation, need for home help, and use of mobility devices).ResultsA total of 84 participants (53%) rated 6 points or more on the PSQI (mean 6.5 points, SD: ±4.2, min‐max 0–18), indicating sleep disturbances. Gender (p = .002) and use of mobility devices (p = .036) explained 9.5% of the variance in PSQI.ConclusionSurvivors of stroke report sleep disturbances even several years after stroke onset. Women and those using mobility devices, indicating less recovery after stroke, report sleep disturbances to a higher degree, regardless of chronological age, time since stroke onset, other stroke characteristics, comorbidities, and sociodemographic data. Further studies with a longitudinal design are needed to gain a comprehensive understanding of how stroke‐related factors and other reasons account for poststroke sleep disturbances in order to improve treatment and rehabilitation.
Docking guidance with experimental ligand structural density improves docking pose prediction and virtual screening performance
Authors: Hansel‐Harris Althea T. , Tillack Andreas F. , Santos‐Martins Diogo , Holcomb Matthew , Forli Stefano 
Published: February 2025

AbstractRecent advances in structural biology have led to the publication of a wealth of high‐resolution x‐ray crystallography (XRC) and cryo‐EM macromolecule structures, including many complexes with small molecules of interest for drug design. While it is common to incorporate information from the atomic coordinates of these complexes into docking (e.g., pharmacophore models or scaffold hopping), there are limited methods to directly leverage the underlying density information. This is desirable because it does not rely on the determination of relevant coordinates, which may require expert intervention, but instead interprets all density as indicative of regions to which a ligand may be bound. To do so, we have developed CryoXKit, a tool to incorporate experimental densities from either cryo‐EM or XRC as a biasing potential on heavy atoms during docking. Using this structural density guidance with AutoDock‐GPU, we found significant improvements in re‐docking and cross‐docking, important pose prediction tasks, compared with the unmodified AutoDock4 force field. Failures in cross‐docking tasks are additionally reflective of changes in the positioning of pharmacophores in the site, suggesting it is a fundamental limitation of transferring information between complexes. We additionally found, against a set of targets selected from the LIT‐PCBA dataset, that rescoring of these improved poses leads to better discriminatory power in virtual screenings for selected targets. Overall, CryoXKit provides a user‐friendly method for improving docking performance with experimental data while requiring no a priori pharmacophore definition and at virtually no computational expense. Map‐modification code available at: https://github.com/forlilab/CryoXKit.
Translation, Cross‐Cultural Adaptation, and Psychometric Validation of the Turkish Version of the “Expanded Prostate Cancer Index Composite (EPIC)” in Prostate Cancer Patients
Authors: Tilki Burak , Hurmuz Pervin , Yuce Deniz , Ozyigit Gokhan , Akyol Fadil 
Published: February 2025

ABSTRACTPurposeThe Expanded Prostate Cancer Index Composite (EPIC) is a symptom scale that measures health‐related quality of life (HRQoL) in prostate cancer (PCa) patients. This scale is translated into different languages and used in daily practice. This study aimed to translate the EPIC scale into Turkish and provide Turkish validation by conducting validity and reliability analyses.MethodsPatients with biopsy‐proven PCa who received definitive or postoperative radiotherapy (RT) at our department were included. All participants were evaluated using the Turkish EPIC, The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC‐QLQ) C30, and EORTC‐QLQ PR25 questionnaires at five different time points. First, the original English version of the EPIC was translated into Turkish, and then, two reliability and five validity analyses were performed.ResultsOne hundred‐five patients were included in the study. In the reliability analyses, Cronbach's alpha values of the whole scale were measured at 0.866, and the main scales' Cronbach's alpha values were measured between 0.654 and 0.969. In the test‐retest analysis, the correlation values of the main scales were measured between 0.413 and 0.861. The pilot study with 20 patients was completed, thus providing face validity. Sensitivity to change analysis, interscale correlation, criterion validity, and explanatory factor analyses were performed, and results proving the scale's validity were obtained in all analyses.ConclusionThe Turkish EPIC scale is applicable for patients in the Turkish population diagnosed with PCa who received either definitive or postoperative RT.
Quantitative Study on UAV Operational Risk Based on Specific Operation Risk Assessment Model
Authors: Zheng Bo , Zhou Wenjie , Ma Xin 
Published: February 2025

ABSTRACTThe Specific Operation Risk Assessment (SORA), developed by the Joint Authorities for Rulemaking on Unmanned Systems (JARUS), is a core methodology in unmanned aerial vehicle (UAV) safety management. While the traditional SORA model plays a critical role in UAV operational risk assessment, its evaluation processes for ground and air risks rely on discrete qualitative risk factors, leading to limitations in applicability and real‐time responsiveness. To address these shortcomings, this paper proposes an improved quantitative assessment method for ground and air risks, significantly enhancing the precision and adaptability of risk evaluation. The proposed approach employs a collision risk assessment algorithm based on dynamic path prediction and perturbation analysis to accurately estimate UAV‐to‐UAV collision probabilities. Additionally, the Expectation–Maximization (EM) algorithm is introduced to model the mixture Gaussian distribution of bird flocks, enabling a more accurate evaluation of UAV‐to‐bird collision risks. Gradient descent is utilized to optimize UAV flight paths, testing the algorithm's performance in assessing corrective measures. Experimental results demonstrate that the improved quantitative assessment method for ground and air risks not only captures subtle changes in dynamic risk environments but also significantly enhances the real‐time performance and accuracy of risk evaluations. Compared to the traditional SORA model, the proposed quantitative method exhibits higher sensitivity and reliability in risk assessment and validation of corrective measures.
H2/H∞$$ {H}_2/{H}_{\infty } $$ Control of AETSCP‐Based IT‐2 Fuzzy Networked Control Systems Under Stealthy Dos Attacks and Actuator Faults
Authors: Zhu Yunjiao , Tang Xiaoming , Wang Jun , Zhai Shidong , Yuan Jingjie , She Minghong 
Published: February 2025

ABSTRACTThis paper examines the dynamic output feedback control of interval type‐2 (IT‐2) fuzzy systems suffering from stealthy denial of service (DoS) attacks under the adaptive event‐triggered stochastic communication protocol (AETSCP). Considering the advantages of the AET mechanism and the SCP, a new AETSCP is proposed, whose trigger parameters can be dynamically adjusted based on the changing trend of the system state and the stealthy DoS attack probability. The signal‐to‐interference plus noise ratio (SINR)‐based DoS attacker continuously senses the channel and utilizes the trigger characteristics of the AET mechanism to cleverly launch the attack to ensure its stealthiness. A dynamic quantizer is employed to quantize the measured output, and a time‐varying fault matrix is adopted to represent actuator faults. By applying the mode‐dependent Lyapunov function, the sufficient condition to ensure the stability of the considered networked control system (NCS) is derived, and the dynamic output feedback controller satisfying the performance is designed. Lastly, a simulation example is used to verify the effectiveness of the proposed algorithm.
Green Synthesis of Silver Nanoparticles Using Carica Papaya Leaf Extract and Its Anticancer Activities through Regulation of Microtubule Dynamics in Breast Cancer
Authors: Mukherjee Rimi , Talukdar Debojit , Mukherjee Poulami , Guha Subhabrata , Mandal Gautam Kumar , Mitra Debarpan , Naskar Rahul , Mandal Sanmitra , Alam Neyaz , Sahu Sumanta Kumar , Majumder Biswanath , Das Gaurav , Murmu Nabendu 
Published: February 2025

AbstractCarica papaya (CP) is an herbaceous succulent plant extensively used in Asian folk medicine. CP leaves were utilized in the study for rapid eco‐friendly biosynthesis of silver nanoparticles (CP‐AgNP). The CP‐AgNP obtained was spherical (scanning electron microscope images) with a size of 26.5 ± 3.45 nm as evident from transmission electron microscope images with a Zeta Potential of −50 mV. TNBC cell line MDA‐MB 231 was treated with various doses of CP and CP‐AgNP to determine the IC50 values of 2.4 mg/mL and 15.13 µg/mL, respectively. Cell cycle analysis disclosed a G2/M arrest upon administration of the treatments. The tubulin depolymerization potential of the treatments affirmed perturbation of tubulin polymerization instigated the apoptosis by ROS induction. Further testing of the treatments in an in vivo and patient‐derived ex vivo culture platform elicited tumor growth reduction. The current study identified a few probable tubulin‐disrupting candidates in our crude CP extract through molecular docking. Some of the major challenges of the cancer drug delivery addressed by our nanoformulation are increased stability, higher levels of biocompatibility, and reduced toxicity. Our data supports that modifications coupled with targeted delivery of CP‐AgNP can act as a novel anticancer therapeutic.
Noncollinear Magnetism in Fe3O4 Induced via Site‐Selective Rare‐Earth Substitution Boosting Its Saturation Magnetization
Authors: Li Haining , Kobayashi Masaki , Kou Sonju , Sarker Md Shamim , Ahamed E M K Ikball , Yamagami Kohei , Fukushima Tetsuya , Ma Kaijie , Ma Shuting , Takeda Takahito , Okano Ryo , Assadi M. Hussein N. , Yamahara Hiroyasu , Katayama‐Yoshida Hiroshi , Tabata Hitoshi , Seki Munetoshi 
Published: February 2025

AbstractSubstituting rare‐earth Eu ions with a large atomic number into 3d transition metal oxides can precisely control their magnetic properties through significant spin‐orbit coupling, leading to noncollinear magnetism. Experimental investigations are combined with density functional theory to explore site‐selective Eu3+ substitution as a strategy to enhance the magnetic properties of Fe3O4 thin films. The substitution location of Eu3+, that is, octahedral versus tetrahedral, is confirmed by electrical resistivities and valence band photoemission measurements. Tetrahedrally Eu‐substituted Fe3O4 exhibited an exceptionally enhanced saturation magnetization MS of up to 4.4 μB/f.u. because of noncollinearity, whereas octahedrally Eu‐substituted Fe3O4 showed significantly reduced MS. X‐ray absorption spectroscopy and X‐ray magnetic circular dichroism measurements clearly revealed that in the tetrahedrally Eu‐substituted Fe3O4, the Eu3+ magnetic moment positively contributed to the orbital magnetic moment that exhibited strong magnetic anisotropy. The deviation of the observed MS from the lower value predicted by Néel's theory of collinear ferrimagnetism further supported the role of noncollinearity. These results provide empirical evidence for the spin configuration of tetrahedrally Eu‐substituted Fe3O4 and a new perspective for designing practical ferrimagnetic 4f compounds with exceptional MS.
Halide‐Directed Ligand Engineering Enables Expedient, Controlled and Divergent Syntheses of Diphosphine‐Protected Au Nanoclusters
Authors: Li Ying‐Zhou , Liu Zhi‐Shuai , Liu Wen‐Yan , Yuan Zhi‐Rui , Yang Peng‐Fei , Xu Jing , Hao Fei , Wang Jin‐Gui , Wang Nian‐Xing , Azam Mohammad , Sun Di 
Published: February 2025

AbstractDespite substantial progress in ligand engineering, the efforts in the field of Au nanoclusters have been concentrated almost exclusively on organic ligands. Halides, the most typical auxiliary inorganic ligands widely present in Au clusters, remain virtually unexplored, particularly regarding their effects on cluster construction. Herein, diphosphine Ph2P(CH2)nPPh2 (Ln, n = 1–6) is chosen as the co‐protecting organic ligands and a comparative analysis on the influential roles of halide ions (Cl−, Br−, I−) in guiding Au cluster synthesis is conducted. A simple yet efficient halide‐directed synthetic approach has been developed and a series of Au nanoclusters, including the known [Au18(L1)6Br4]2+, [Au13(L2)5Cl2]3+ and [Au8(L3)4Cl2]2+ that however crystallized in new polymorphic forms, as well as the new reduction‐active [Au18(L1)6Cl4]2+, luminescence‐enhanced [Au14(L3)5Br4]2+ and core‐isomeric [Au11(Ln)4X2]+ (n = 4–6; X = Cl, Br, I), are obtained in a more expedient and controllable manner. This work clearly demonstrates the non‐negligible roles of halide ions in directing cluster synthesis, and provides an easier access to diverse diphosphine‐protected Au nanoclusters. This approach, promising in gram‐scale synthesis, is expected to further extend the ligand scope and holds promise for advancing the diversified syntheses of a broader range of ligand‐protected metal nanoclusters.
Moral Judgments Around Experiences of Health Risks
Authors: Burton-Jeangros Claudine 
Published: February 2025

Abstract
In dealing with risk, institutions and individuals elaborate different forms of social control. The distinction between proper and inadequate attitudes and actions toward risks generates moral judgments. Some individuals or groups are typically blamed for not acting according to the dominant definitions of risk. These social mechanisms reproduce or make explicit the power relationships between different categories entitled to define appropriate ways to deal with danger. Such blaming mechanisms are particularly common when new threats emerge, such as infectious diseases but also during times of social change, since they unsettle the established social order. Prevention campaigns providing information on different health risks contribute to setting boundaries between others who are dangerous—because they are infected or because they smoke, for example—and the virtuous self. Efforts to control risks thus generate stigmatization and discrimination. Considering that risk surveillance introduces suspicion in social relationships, this chapter shows how interpretations of risk and uncertainty exacerbate preexisting social and cultural divisions when making sense of emerging threats.
Recognition and Calculation of Fish Rafts in Mariculture on the Basis of Artificial Intelligence
Authors: Zhang Weibo , Zhang Li , Zhong Yaozhao , Lin Peitu , Zhang Feng 
Published: February 2025

Abstract
Mariculture is crucial for grain security and sustainable development, but identifying and counting for the different types of mariculture remains a challenge. In this research, the data of satellite remote sensing, unmanned aerial vehicle (UAV) and shore-based camera is adopted to collect high-definition pictures, and the deep learning algorithm is adopted to detect and position the marine aquaculture areas. Then the classification model of convolutional neural network is adopted to identify the aquaculture species, and the OpenCV model is adopted to assess the area of aquaculture area. The approach obviously improves the efficiency and accuracy of marine aquaculture type identification and area assessment, reduces the subjectivity and error rate of manual statistics, has higher robustness and applicability, can further optimize the algorithm in the future, and is expanded to be applied to the scope on ocean environment monitoring, fishery management and the like.