bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of Breast Cancer Diseases From Genes Using Pso and Cso Tuned Long Short-term Memory
Authors: Gini J. Godly , Padmakala S. 
Published: April 2024

Abstract
Gene data set collected from a diverse population gene expression profiles, genetic variations, and clinical attributes for earlier detection cancer. Time Series Forecasting (TSF) techniques are applied and exploits temporal dependencies within the gene data, enables the prediction of breast cancer and progression. The proposed methodology such as Particle Swarm Optimization-Long Short Term Memory (PSO & LSTM) and Cat Swarm Optimization -Long Short Term Memory (CSO & LSTM) combines with gene data augmentation and analyse the temporal patterns breast cancer genes. Receiver Operating Characteristic (ROC) curve is used for evaluation the proposed models predictive performance. The proposed methods are validated in traditional dataset and collected gene data sets, from National Center for Biotechnology Information (NCBI). The results are compared with existing classification model and evaluated the effectiveness of the TSF methods such as of CSO-LSTM and PSO-LSTM in prediction of breast cancer diseases. The proposed methods contribute to early detection by leveraging time series forecasting techniques. The proposed model improves the accuracy of and reliability of breast cancer prediction, which enables health professional with more information and potentially enhances the patient outcomes
Mouth gel containing phthalocyanine derivative attenuates TNF-α through NF-κB inhibition in experimental periodontitis
Authors: Breseghello Isadora , Bruzadelli Rafaela Franco Dias , Rosalen Pedro Luiz , Araújo Leonardo Pereira , Abdalla Henrique Ballassini , Lazarini Josy Goldoni , Paiva Isadora Marques , Bueno-Silva Bruno , Alencar Severino Matias , Vilhena Fabiano Vieira , Cunha Thiago Mattar , Ikegaki Masaharu , Fernandes Leandro Araújo , Franchin Marcelo 
Published: April 2024

Abstract
Background
Tumor necrosis factor alpha (TNF-α) is a major cytokine involved in periodontal disease pathogenesis due to its ability to modulate inflammatory cytokine production and cell influx in tooth-supporting tissues. Therefore, TNF-α is an excellent target for limiting the inflammatory process and avoiding alveolar bone resorption and tooth loss.
Objective
This study investigated the activity and action mechanism behind the anionic iron phthalocyanine (AI-PhyC) derivative on TNF-α production and the impact on experimental periodontitis.
Methods
RAW 264.7 macrophages were treated with AI-PhyC, and cell viability (MTT) was assessed. Afterward, cells were treated with AI-PhyC, primed with LPS (10ng/mL), and the TNF-α levels were measured, as well as the NF-kB activation and the gene expression of Ikkβ. Subsequently, a mouth gel containing 1% AI-PhyC was topically administered in the gingival tissue of mice with periodontitis ligature-induced. Bone loss and the gene expression of Tnfα, Ikkβ, p65 (NF-κB), and receptor-activating nuclear factor kappa B ligand (Rankl) were quantified in the gingival tissue. Lastly, the systemic toxicity of AI-PhyC was estimated in Galleria mellonella larvae.
Results
In an activated RAW 264.7 macrophage cell culture, AI-PhyC at 100µM reduced TNF-α release, nuclear factor kappa B (NF-kB) activation and mRNA expression of Ikkβ. Regarding the experimental periodontitis, topical application of mouth gel containing 1% AI-PhyC blockage alveolar bone loss. Additionally, 1% AI-PhyC reduced the mRNA expression of Tnfα, Ikkβ, p65 (NF-κB), and Rankl in the gingival tissue. Finally, administering AI-PhyC ranging from 1 to 1000mg/kg did not present acute systemic toxicity (72h) in G. mellonella.
Conclusion
Overall, we demonstrate the potential of mouth gel containing AI-PhyC as a therapeutic strategy for managing osteolytic inflammatory disorders, such as periodontitis.
Associations between plasma angiopoietin-like protein 3 (ANGPTL3) levels and severity of coronary artery disease
Authors: zhao zihao , wang yuexi 
Published: April 2024

Abstract
Objective
Angiopoietin-like 3 (ANGPTL3), a member of the angiopoietin-like protein family exclusively synthesized in the liver, has been demonstrated to be a critical regulator of lipoprotein metabolism to inhibit lipoprotein lipase (LPL) activity .However, the relationship between serum ANGPTL3 level and CAD is still unclear. This study aims to explore the relationship between serum ANGPTL3 level and CAD.
Methods
In this case-control study, 236 subjects were divided into CAD group (n = 187) and control group (n = 49). The Gensini scoring system was used to assess the severity of CAD.Plasma ANGPTL3 levels were measured by an enzyme-linked immunosorbent assay kit. The associations between plasma ANGPTL3 levels and CAD were determined by multivariate logistic regression analysis. The association between ANGPTL3 levels and Gensini scores was determined by multivariate linear regression analysis.
Results
Serum ANGPTL3 levels in CAD group was significantly higher than that in control group(0.40 ± 0.06vs0.32 ± 0.06ng/ml,p < 0.001). After adjusting confounding factors, serum ANGPTL3 level was found to be an independent risk factor for CAD (OR = 5.03, 95%CI = 2.79–9.07, P < 0.001), and ANGPTL3 level was positively correlated with Gensini score(B = 5.192,95% CI 0.854–9.529, P = 0.019).
Conclusion
Compared with the control group, serum ANGPTL3 levels was significantly increased in CAD patients. Serum ANGPTL3 level is an independent risk factor for CAD and is positively correlated with the severity of CAD.
Challenges to research implementation during public health emergencies: anecdote of insights and lessons learned during the COVID-19 pandemic in Gujarat, India
Authors: Memon Farjana , Jobarteh Modou L. , Shah Komal , Sinha Anish , Patel Monali , Patil Shailee , Heffernan Claire , Saxena Deepak B 
Published: April 2024

Abstract
Background: Health emergencies, including pandemics, are not entirely new occurrences; some notable ones occurred in the past. However, the scale of the COVID-19 pandemic is unprecedented. The COVID-19 pandemic exposed the unpreparedness of national health systems in effectively managing health emergencies. During the pandemic, controlling the spread of the virus and hopes of exiting into a post-pandemic era were reliant on research to improve patient care and inform government policies. Nonetheless, research implementation during health emergencies can be challenging in low-resourced settings. This paper presents anecdotes of experiences encountered in implementing a research project during the COVID-19 pandemic in Gujarat, India, and offers insights into ways research can be supported during health emergencies.
Methods: We implemented a longitudinal study to investigate the impact of the COVID-19 pandemic, including SARS-CoV-2 infection, during pregnancy on birth outcomes, growth, and development in early childhood. The study utilises hospital records and databases to recruit women who were infected with SARS-CoV-2 during pregnancy and those with no known infection. Mother-infant pairs in the infected and uninfected group were then followed longitudinally for over 3 years.
Results: Observations of challenges encountered during implementation of the research, including those related to planning, retrieval of hospital records, tracking, recruitment, and follow-up of eligible women were recorded by study staff, and the observations produced as anecdotes. The challenges observed are group into three overarching themes: a) individual factors, b) health system challenges, and c) research operational challenges. Some notable observations include misinformation, misconception, mistrust, underdeveloped health record systems, stigma, and hesitance.
Conclusion: We believe early planning, effective communication, and community awareness are likely to be helpful in implementing a successful research project. Additionally, efforts at improving collaboration and co-creation between health practitioners, researchers and the public may benefit the implementation of research projects during a health emergency.
The Discovery and Excavation of Artefacts from Pulau Melaka Reclamation Land, Malaysia
Authors: Saiffuddin Amir Husaini , Hasni Muhammad Termizi , Arbi Ruzairy , Kee Soo Chen , Mustapa Baharim , Sharma Dionysius , Shaari Hasrizal 
Published: April 2024

Abstract
The accidental discovery of wood fragments in a reclaimed area near Pulau Melaka by a group of independent researchers at the end of 2020 caught the attention of the National Heritage Department (JWN) and Melaka Museum Corporation (PERZIM). This is the first discovery ever where the wood fragments were found in a reclaimed land in Malaysia. Furthermore, these wood fragments were expected to be part of the ancient shipwreck structure, which was supposed to be the transitional period between the Melaka Malay Sultanate and Portuguese occupation between the late 15th to early 16th centuries. However, since these findings were discovered on reclaimed land, it is highly questionable whether the integrity of its original context is still preserved. Thus, several aspects have been considered such as suitable preliminary surveying methods, effective excavation procedures and subsequently the analysis of the recovered artefacts and wood fragments. This article discusses the discovery and process of surveying and initial excavation of the Pulau Melaka archaeological site. The outcomes of this study provide a guideline for future archaeological excavation on reclaimed land or any other disturbed environment in Malaysia.
Factors associated with Change in Quality of Life and Family Functioning Scores of Parental Caregivers of Children and Young People with Primary Brain Tumour in Karachi, Pakistan: A Prospective Cohort Study
Authors: Zahid Nida , Enam Syed Ather , Mårtensson Thomas , Azam Iqbal , Mushtaq Naureen , Moochhala Mariya , Kausar Faiza , Hassan Aneesa , Bakhshi Saqib , Javed Farrukh , Rehman Lal , Mughal Muhammad Nouman , Altaf Sadaf , Kirmani Salman , Brown Nick 
Published: April 2024

Abstract
Background
There are limited data available, particularly in low- and middle-income countries (LMICs), on long-term quality of life (QoL) and family functioning of parental caregivers to children and young people (CYP) affected by primary brain tumours (PBTs). This study aimed to assess the factors associated with mean change in QoL and family functioning scores of parental caregivers of CYP with PBTs 12 months post-treatment.
Methods
This prospective cohort study enrolled CYP aged 5–21 years with newly diagnosed PBTs and their parental caregivers. The study was carried out between November 2020 and July 2023. The responding parental caregivers (mothers) were recruited from the two major tertiary care centers in Karachi, Pakistan. The parental QoL was assessed by the Pediatric Quality of Life Inventory (PedsQL) Family Impact Module. The assessment was undertaken by a psychologist at the time of the diagnosis and 12 months post-treatment. The data were analyzed by STATA version 12.
Results
Forty-eight CYP with newly diagnosed PBTs and their mothers were enrolled. At 12-month post-treatment 25 (52%) of CYP and their mothers were reassessed and 23 (48%) were lost to follow-up. On multivariable analysis, a significant decline in mothers’ mean 12-month post-treatment QoL and family functioning scores were associated with CYP having post-treatment seizures (beta= -10.2; 95% CI: -18.4 to -2.0) and financial burden associated with the CYP’s illness (beta= -0.3; 95% CI: -0.4 to -0.1). However, in those cases where CYP had higher post-treatment quality of life scores (beta = 0.4; 95% CI: 0.1, 0.6) and post-treatment higher verbal intelligence scores (beta = 0.1; 95% CI: 0.01, 0.3), the QoL and family functioning scores of the mothers were significantly increased.
Conclusion
We found a significant decline in maternal QoL where there was a high financial burden and whose CYP had post-treatment seizures. However, those who’s CYP had higher post-treatment verbal intelligence scores and quality of life scores had a significant increase in their QoL scores. Identification of the factors that influence parental QoL has the potential to enable the development of targeted strategies to alleviate stressors and improve the overall quality of life for mothers and their children who are at high risk.
Selecting the Most Suitable Material for Punch Dies

Using CES EduPack
Authors: Athil  
Published: April 2024

Abstract
The purpose of this paper is to perform a material’s selection for punch dies using CES EduPack. This study is an initial statement of a problem showing how designers can select a small subset of most promising materials from a huge list of options. It identifies the objectives and constraints related to the given functional component and clarifies how that can be used to make the material’s selection. The results revealed that high-speed tool steel is the most suitable material that meets the performance requirements of punch dies.
Estimation of the Weibull Extension Model Parameters Based on Adams’s Method
Authors: Maswadah M. 
Published: April 2024

Abstract
In parameter estimation techniques, the Bayes method is the most commonly used technique in social sciences and psychology, despite its subjectivity to prior information other than data. Thus, the main objective of this paper is to introduce a numerical estimation method, which is the Adams’ method for deriving the estimators for the Weibull extension model parameters and compared to the Bayes method based on different priors via Monte Carlo simulations. The simulation results are strongly favorable to Adams’ method, which provides better estimates and outperforms Bayes’ method. Finally, numerical examples are given to demonstrate the efficiencies of the proposed methods based on the generalized progressive hybrid censoring data.
The rate of deaths from heart diseases in Damascus Hospital and its relationship to the type of disease, gender, age and risk factors
Authors:   Mohammad Jaidouri 1 , Ibrahem Alshhada 1 ,Marwan Shamia 1, 2
Published: April 2024

Abstract
Background
Heart attacks occur as a result of blockage of the coronary artery, which leads to insufficient blood supply to the heart muscle, and the heart will strain to obtain oxygen nutrients.
if this condition is not treated early , the heart muscle can be affected and suffer significant damage , leading to irreversible heart failure and to death. This paper reviews the assessment of the rate of deaths from heart diseases and its relevance with risk factors and examines the importance of an interprofessional team approach to its management.
Materials and Methods
A cross-sectional study was conducted in Damascus Hospital in Damascus by returning to the archives of deaths who had a heart disease and had one or more risk factors to obtain other information from and finally the statistical analysis was performed using the SPSS-25 program.
Results
The sample included in our study 200 patients , and by studying the relationships between mortality in types of heart disease and Age/ Family history / Smoking/ Alcohol/ High cholesterol and triglycerides/ Obesity/ hypertension / diabetes / we found a statistically significant relationship (P<0.05) but on the other hand, we did not find a statistical relationship(P>0.05) between mortality in types of heart disease and Gender .
Conclusion
Age/ Family history / Smoking/ Alcohol/ High cholesterol and triglycerides/ Obesity/ hypertension /diabetes / could be considered as risk factors leads to death in types of heart disease in our study study.
Ausschreibungsverfahren bei Gebietskonzessionen für thermische Netze am Beispiel der Stadt Zürich
Authors: Abegg Andreas , Seferovic Goran 
Published: April 2024

Die Schweiz strebt die Dekarbonisierung der Wärmeversorgung an, wobei thermische Netze eine wichtige Rolle spielen. Gemeinden betreiben oder fördern diese Netze zunehmend, um klimaschonende Effekte zu erzielen und die Abhängigkeit von Erdgasimporten zu verringern. Am Beispiel der Stadt Zürich, welche die Erschliessung bestimmter Gebiete mittels der Vergabe von exklusiven Gebietskonzessionen vorsieht, untersucht der Beitrag die Anforderungen, welche das Beschaffungsrecht und das Binnenmarktgesetz an die Verleihung solcher Konzessionen stellt. Während die Kantone solche Verfahren zwar vom Anwendungsbereich des Beschaffungsrechts ausnehmen können, bleiben sie an die Vorgaben des Binnenmarktgesetzes gebunden. Es ist den Kantonen zu empfehlen, ihre Vergabeverfahren auch in diesen Fällen an den Grundsätzen des Beschaffungsrechts zu orientieren, um sicherzustellen, dass die Verfahren transparent, objektiv und diskriminierungsfrei durchgeführt werden.
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La Suisse vise à réduire l'empreinte carbone de son approvisionnement en chaleur. Dans ce contexte, les réseaux thermiques jouent un rôle important. De plus en plus de communes exploitent ou promeuvent de tels réseaux afin d'avoir un impact positif sur le climat et de réduire leur dépendance au gaz naturel importé. La ville de Zurich, par exemple, prévoit d'approvisionner certaines zones par l'octroi de concessions territoriales exclusives; cet article examine les exigences imposées par le droit des marchés publics et le droit du marché intérieur pour l'adjudication de telles concessions. Si les cantons peuvent exclure ce type de procédures du champ d'application du droit des marchés publics, elles restent soumises aux règles du droit du marché intérieur. Il est toutefois recommandé aux cantons de fonder ces procédures d'adjudication sur les principes du droit des marchés publics, afin de s'assurer qu'elles sont transparentes, objectives et non discriminatoires.
The synthesis of MgO/Zein nanocomposites to improve anti-bacteria characteristics of mouthwash
Authors: Rohmawati Lydia , Muadhif Fariz Irkham , Putri Nugrahani Primary , Kusumawati Diah Hari , Munasir  , Darminto  
Published: April 2024

Mouthwash is an alternative to address problems in the oral cavity, such as caries, periodontal inflammation, and microbial abscesses generally caused by pathogens. However, chlorhexidine contained in the mouthwash was limited concentration, i.e., 0.2 %, due to the side effects caused by these ingredients. Even though chlorhexidine has bactericidal and bacteriostatic properties against various bacteria found in plaque, for this reason, to increase the antibacterial activity of these mouthwashes, it is necessary to add other ingredients to the mouthwash formula, namely MgO/Zein nanocomposites with a composition of 1:4 and 1:5. The method used in this study was the preparation of MgO nanoparticles from dolomite using a solid acid solvent, the results of which were then composited with Zein using alcohol and NaOH. Synthesized samples were characterized using XRD, FTIR, SEM, and TEM. The antibacterial activity of S. aureus and mushrooms C. albicans in mouthwash with a concentration of 0.5 to 2.5 % can be determined by conducting a diffusion test. The results showed that the MgO/Zein nanocomposite fabrication had been successfully carried out and had the following characteristics: having a MgO phase with a polycrystalline cubic structure, having a zein phase with α-helix and β-sheet structures of proteins shows that Zein has an amorphous structure. The results of the antibacterial activity test showed that mouthwash with adding MgO/Zein nanocomposites more effectively inhibited bacterial growth of S. aureus and mushrooms C. albicans. It is known that the MgO/Zein nanocomposite composition 1:4 has the largest inhibition zone in S. aureus bacteria with a concentration of 1.5 % mouthwash and C. albicans fungi with a concentration of 0.5 %, namely 40.17 mm and 8.42 mm
Study of the influence of lateral forces and velocity on the lateral dynamics of automobile
Authors: Nguyen Tuan Xuan , Bui Hai Van 
Published: April 2024

Stability of a car's trajectory of motion is the ability of a car to retain its required state of motion, under different conditions of motion. Depending on different states of motion, cars can lose direction of motion instability when there is a lateral force, due to vehicle speed, due to turning or braking the road with different grip coefficients on the sides of the wheel. In such complex moving conditions, cars need to keep a stable trajectory of movement under the driver's control. The paper examines the stability of the car's trajectory in linear motion conditions with the influence of lateral forces and the velocity of the vehicle, these two factors act to change the state of movement of the vehicle, which significantly affects the safety of the vehicle's movement. The authors looked at the effect of vehicle velocity and lateral forces on vehicle transverse dynamics: lateral forces caused by horizontal winds, inclination of the road surface, speed of movement of the vehicle acting on the entire body create centrifugal inertial forces; this force acts to cause the tires to deform. At this point the vehicle is shifted from its original trajectory. In the research content, the authors built a lateral Dynamics Model, in which the influencing factors are set as inputs to the model including vehicle velocity and transverse wind forces, output is the rotation angle of the body, transverse acceleration and horizontal displacement of the vehicle. The simulation results showed that the effect of vehicle speed was relatively large: lateral displacement increased by 228 % at a speed of 120 km/h. Therefore, when driving on the highway, there should always be driver control to ensure that the car does not deviate from the lane
Development of a method for predicting barrel wear resistance when using ammunition with a long storage life
Authors: Anipko Oleg , Baulin Dmitro , Horielyshev Stanislav , Boikov Igor , Medvid Mykhailo , Babkov Yurii , Nakonechnyi Aleksandr , Kolomiitsev Oleksandr , Gleizer Natalia 
Published: April 2024

Despite the fact that a large amount of small arms ammunition has been used up over the past two years, their stocks in warehouses and arsenals in various countries are quite large. And their shelf life is 20 years or more. In addition, over time, the number of such ammunition will increase.
Among the large number of requirements for modern small arms, one can highlight the provision of the necessary survivability of its parts and mechanisms. The problem of barrel survivability is especially important.
One of the factors affecting barrel survivability is changes in internal ballistics parameters. In turn, these parameters change when using ammunition whose service life exceeds the warranty.
In this regard, the task of studying the survivability indicators of small arms barrels when using post-warranty ammunition seems relevant.
The requirements for barrel systems and factors affecting the wear of the barrel bore of powder charges during long-term storage have been determined.
An analysis of changes in the ballistic characteristics of powder charges was carried out, which allows to state increased wear of barrels when using ammunition with long storage periods.
The dependencies for determining the limit number of shots from a weapon sample are analyzed.
A method for predicting barrel survivability when using long-term storage ammunition is proposed.
Data are presented on an experimental study to determine changes in barrel survivability as a result of the use of long-term storage ammunition by estimating changes in the initial velocity of the projectile.
Based on the results obtained, ways for further research are proposed in the direction of expanding the range of ammunition and weapons