bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two-Year Longitudinal Study Reveals That Long COVID Symptoms Peak and Quality of Life Nadirs at 6–12 Months Postinfection
Authors: Demko Zoe O , Yu Tong , Mullapudi Sarika K , Varela Heslin M Gabriela , Dorsey Chamia A , Payton Christine B , Tornheim Jeffrey A , Blair Paul W , Mehta Shruti H , Thomas David L , Manabe Yukari C , Antar Annukka A R 
Published: March 2024

Abstract

Background
Few longitudinal studies available characterize long COVID outcomes out to 24 months, especially in people with nonsevere acute coronavirus disease 2019 (COVID-19). This study sought to prospectively characterize incidence and duration of long COVID symptoms and their association with quality of life (QoL) from 1–24 months after mild-to-moderate COVID-19 using validated tools in a diverse cohort of unvaccinated people infected with SARS-CoV-2 in 2020.

Methods
At 1–3, 6, 12, 18, and 24 months post-COVID-19, 70 participants had orthostatic vital signs measured, provided blood, and completed surveys characterizing symptoms, QoL, and return to pre-COVID-19 health and activities using validated tools (FLU-PRO+, Fatigue Severity Scale, Insomnia Severity Index, General Practitioner Assessment of Cognition, Patient Health Questionnaire Depression 8-Item, Generalized Anxiety Disorder 7-Item, 36-Item Short-Form Health Survey, EuroQol EQ-5D-5L).

Results
During the study period, 33% of participants experienced long COVID (had not returned to pre-COVID-19 health status and reported at least 1 symptom &gt;90 days postinfection); 8% had not returned to their pre-COVID-19 health status 24 months postinfection. Long COVID symptoms peaked 6 months post-COVID-19, frequently causing activity limitations. Having long COVID was significantly associated with decreased QoL in multiple domains. Frequencies of orthostatic hypotension and tachycardia reflected levels reported in the general population. Within-person weight increased significantly between months 1 and 6. Long COVID was associated with pre-COVID-19 obesity and hyperlipidemia, but not with high-sensitivity C-reactive protein levels 1–3 months postinfection.

Conclusions
Long COVID occurs in a significant proportion of unvaccinated people, even if the acute illness was not severe. Long COVID prevalence peaked 6–12 months post-COVID-19, and a small proportion of participants still reported not returning to their pre-COVID-19 health status 24 months post-COVID-19.
All-cause and Infection-attributable Mortality Amongst Adults With Bloodstream Infection—a Population-based Study
Authors: Underwood Jonathan , Griffiths Rowena , Gillespie David , Akbari Ashley , Ahmed Haroon 
Published: March 2024

Abstract

Background
Bloodstream infections (BSIs) are common, life-threatening infections. However, it remains unclear whether deaths following BSIs are primarily from uncontrolled infection or underlying comorbidities. We aimed to determine the overall mortality, infection-attributable mortality, and causes of death for four leading BSI pathogens.

Methods
This retrospective cohort study was conducted within the Secure Anonymized Information Linkage Databank, containing anonymized population-scale electronic health record data for Wales, UK. We included adults with Escherichia coli, Klebsiella spp, Pseudomonas aeruginosa, and Staphylococcus aureus BSI between 2010 and 2022 using linked data from Public Health Wales and the Office for National Statistics. Thirty-day all-cause and sepsis-specific mortality, as a proxy for infection-attributable mortality, were compared using Cox proportional hazards and competing risk regression, respectively.

Results
We identified 35 691 adults with BSI (59.6% E coli). Adjusted analyses revealed that all organisms had a higher 30-day mortality versus E coli with Pseudomonas aeruginosa the highest (hazard ratio, 1.96 [1.76–2.17], P &lt; .001). Cancer was the leading cause of death following BSIs for all organisms, particularly deaths occurring between 30 and 90 days (35.9%). A total of 25.5% of deaths within 30 days involved sepsis. Methicillin-resistant Staphylococcus aureus was associated with the highest sepsis mortality versus E coli (hazard ratio, 2.56 [2.10–3.12], P &lt; .001). Peak C-reactive protein was positively associated with increased sepsis mortality (P &lt; .001).

Conclusions
This population-level study challenges the assumption that most deaths following BSIs are directly attributable to uncontrolled infection, particularly subacutely more than 30 days from BSI. Our findings underscore the need for reevaluating clinical trial design and developing better preventive strategies for BSIs.
Peak energy–isotropic luminosity correlation and jet opening angle evolution in Swift-BAT short GRBs with soft-tail emission
Authors: Ogino Naoki , Yonetoku Daisuke , Arimoto Makoto , Sawano Tatsuya , Hamidani Hamid 
Published: March 2024

Abstract
Some short gamma-ray bursts (SGRBs) exhibit a short-duration and spectral hard emission (referred to as a “hard spike”) followed by a slightly longer soft emission (known as a “soft tail”). We identified nine SGRBs with the known redshift in the Swift/BAT gamma-ray burst catalog by specifically searching for the soft tail. We found that the spectra of these SGRBs can be described as a cutoff power-law model for the hard spike and the soft tail, and both show a time variation keeping the Epeak–Liso correlation. This suggests that the emission mechanisms of both phenomena are identical. Furthermore, we found a trend of luminosity evolution as a function of redshift. This phenomenon suggests that these bursts originate from sources that are intrinsically bright and/or energy-density-concentrated within a narrower jet at higher redshift. We demonstrate that the average jet opening angle, derived from the jet break, can be explained by considering a model based on a strongly redshift-dependent jet opening angle.
Glucose-G protein signaling plays a crucial role in tomato resilience to high temperature and elevated CO2
Authors: Wang Jiao , Luo Qian , Liang Xiao , Liu Hua , Wu Changqi , Fang Hanmo , Zhang Xuanbo , Ding Shuting , Yu Jingquan , Shi Kai 
Published: March 2024

Abstract
Global climate change is accompanied by carbon dioxide (CO2) enrichment and high temperature (HT) stress; however, how plants adapt to the combined environments and the underlying mechanisms remain largely unclear. In this study, we show that elevated CO2 alleviated plant sensitivity to HT stress, with significantly increased apoplastic glucose (Glc) levels in tomato (Solanum lycopersicum) leaves. Exogenous Glc treatment enhanced tomato resilience to HT stress under ambient CO2 conditions. Cell-based biolayer interferometry, subcellular localization, and Split-luciferase assays revealed that Glc bound to the tomato regulator of G protein signaling 1 (RGS1) and induced RGS1 endocytosis and thereby RGS1-G protein α subunit (GPA1) dissociation in a concentration-dependent manner. Using rgs1 and gpa1 mutants, we found that RGS1 negatively regulated thermotolerance and was required for elevated CO2-Glc-induced thermotolerance. GPA1 positively regulated the elevated CO2-Glc-induced thermotolerance. A combined transcriptome and chlorophyll fluorescence parameter analysis further revealed that GPA1 integrated photosynthesis- and photoprotection-related mechanisms to regulate thermotolerance. These results demonstrate that Glc–RGS1–GPA1 signaling plays a crucial role in the elevated CO2-induced thermotolerance in tomato. This information enhances our understanding of the Glc-G protein signaling function in stress resilience in response to global climate change and will be helpful for genetic engineering approaches to improve plant resilience.
Measuring Policy Learning: Challenges and Good Practices
Authors: Zaki Bishoy Louis , Radaelli Claudio M 
Published: March 2024

Abstract
How can we empirically identify and measure policy learning? Through a problematized review, we develop a novel perspective to identifying, explaining, and addressing interconnected ontological, theoretical-contextual, and consequently, methodological challenges in the measurement of policy learning. We de-compose measurement as a three-fold endeavor, concerning: conceptual foundations, the design of measurement instruments, and their deployment in empirical research. Then, we synthesize exemplars of good practice across these three stages and offer a set of recommendations for the refinement of policy learning measurement, while maintaining theoretical and methodological pluralism.
Anti-Asian Racism and the Rise of Hawkish Mass Opinion in China
Authors: Kim D G 
Published: March 2024

Abstract
The dramatic increase in anti-Asian racial violence in the United States during the pandemic has sparked debates on issues of domestic racial justice and deep-seated racism against Asian Americans. Political scientists, however, have paid relatively little attention to how growing anti-Asian racism might affect contemporary U.S.-China relations, especially by shaping foreign policy discourses and public opinion in China. In this article, I investigate the way the Chinese state media discuss the issue and how such top-down discourses shape mass political attitudes and foreign policy preferences in China. Analyzing the Chinese state media coverage of anti-Asian racial violence, I first find that Chinese official narratives frame the issue as a manifestation of both racially motivated American foreign policy and problems with American democracy. By conducting a nationwide survey experiment in China, I then examine the impact of such top-down political rhetoric on public support for hawkish foreign policies. I find that these political narratives significantly boost racialized and nationalist sentiments among the Chinese masses, which, in turn, garner greater public support for hawkish foreign policy. This article contributes to understanding the foreign policy implications of anti-Asian racism after the global pandemic and the potential racialization of Sino-American great-power competition.
One-step biofabrication of liquid core—GelMa shell microbeads for in situ hollow cell ball self-assembly
Authors: Chen Jianwei , Liu Zeyang , Wang Zixian , Zhang Xiuxiu , Zhang Yi , Zhan Zhen , Gong Xiaohua , Xu Tao 
Published: March 2024

Abstract
There are many instances of hollow-structure morphogenesis in the development of tissues. Thus, the fabrication of hollow structures in a simple, high-throughput and homogeneous manner with proper natural biomaterial combination is valuable for developmental studies and tissue engineering, while it is a significant challenge in biofabrication field. We present a novel method for the fabrication of a hollow cell module using a coaxial co-flow capillary microfluidic device. Sacrificial gelatin laden with cells in the inner layer and GelMa in the outer layer are used via a coaxial co-flow capillary microfluidic device to produce homogenous micro-beads. The overall and core sizes of core–shell microbeads were well controlled. When using human vein vascular endothelial cells to demonstrate how cells line the inner surface of core–shell beads, as the core liquifies, a hollow cell ball with asymmetric features is fabricated. After release from the GelMa shell, individual cell balls are obtained and deformed cell balls can self-recover. This platform paves way for complex hollow tissue modeling in vitro, and further modulation of matrix stiffness, curvature and biochemical composition to mimic in vivo microenvironments.
Plaintiff S99: Rewriting Refugee Law Through a Trauma-Informed Lens
Authors: Hambly Jessica , Sanmuhanathan Neeraja 
Published: March 2024

Abstract
Plaintiff S99/2016 v. Minister for Immigration and Border Protection [2016] FCA 483 was a decision of the Australian Federal Court concerning a woman (referred to in the decision as “Plaintiff S99”) who had been recognised as a refugee in the Republic of Nauru, having been transferred there by Australia under an offshore processing agreement. The decision in Plaintiff S99 established an important precedent that many refugees and asylum-seekers in Australia’s offshore processing centres on Manus and Nauru, including children with severe health problems, subsequently relied upon to be transferred to Australia for critical medical care. Drawing on the recent turn towards trauma-informed practice across other areas of law and policy, we ask: what does this mean for refugees, and, more specifically, what does this mean for judgment writing in refugee law? We use our rewrite of Plaintiff S99 to highlight aspects of the decision and its legacy that continue to silence and erase the experiences of refugees, especially refugee women, and frequently contribute to compounding their trauma. Our contribution calls for a reorientation towards “do no harm” principles, which lie at the heart of trauma and violence-informed practice. In particular, our approach to rewriting S99 aims at foregrounding dignity and safety, promoting respect for physical and mental health, and centring the voice, experience, and longer-term protection needs of refugees.
Prospective evaluation of sexual health following radical cystectomy due to bladder cancer
Authors: Nolting Julia , Nitzsche Romy , Kiss Bernhard , Hakenberg Oliver W , Schneidewind Laila 
Published: March 2024

Abstract

Background
There is a lack of data concerning sexual health following open radical cystectomy (RC), especially in elderly patients and women.

Aim
To describe sexual health and its impact on general health as well as survival in patients undergoing standard open RC for the treatment of bladder cancer (BC). Due to limited data, subgroup analysis for elderly patients and women was performed.

Methods
A prospective noninterventional clinical study was performed evaluating sexual health in RC with any kind of urinary diversion due to BC with a follow-up of 12 months after RC. The study was approved by the local ethics review board (A 2021-0175) and was registered at the German Clinical Trial Register (DRKS00026255). Assessment of sexual health was done with the following validated questionnaires: EORTC QLQ-C30 (for quality of life; European Organisation for Research and Treatment of Cancer), EORTC SH22 (for sexual health), and IIEF-5 (5-item International Index of Erectile Function).

Outcomes
The standard measurements of EORTC QLQ-C30, EORTC SH22, and IIEF-5 as well as overall survival.

Results
Thirty-two patients participated in the study with a mean age of 71.5 years (SD, 9.7): 25 (78.1%) were male and 7 (21.9%) were female. Overall there is a heterogenic picture for sexual health in the study population, but sexual satisfaction is significantly higher prior to surgery while the importance of a sex life stays high and stable. Interestingly, the general health score is significantly correlated to sexual satisfaction (Pearson’s correlation; r = 0.522, P = .002) preoperatively but not following surgery: r = 0.103 (P = .665) after 3 months, r = 0.478 (P = .052) after 6 months, r = 0.276 (P = .302) after 9 months, and r = 0.337 (P = .202) after 12 months. The importance of a sex life is still essential for the patients, especially when recovering from RC; nearly the same can be reported for elderly patients. Unfortunately, the data for women are too limited to report robust results.

Clinical Implications
Evaluation, advice, and monitoring of sexual health must be integrated into clinical practice, particularly in women.

Strengths and Limitations
At least to our knowledge, this is the first systematic prospective evaluation of sexual health in patients with BC receiving RC. Due to the small sample size, there is a risk of selection bias.

Conclusion
Sexual health is important for patients with BC receiving RC, and it is an essential part of quality of life, especially in elderly patients.
Sleep-slow oscillation-spindle coupling precedes spindle-ripple coupling during development
Authors: Fechner Julia , Contreras María P , Zorzo Candela , Shan Xia , Born Jan , Inostroza Marion 
Published: March 2024

Abstract

Study Objectives
Sleep supports systems memory consolidation through the precise temporal coordination of specific oscillatory events during slow-wave sleep, i.e. the neocortical slow oscillations (SOs), thalamic spindles, and hippocampal ripples. Beneficial effects of sleep on memory are also observed in infants, although the contributing regions, especially hippocampus and frontal cortex, are immature. Here, we examined in rats the development of these oscillatory events and their coupling during early life.

Methods
EEG and hippocampal local field potentials were recorded during sleep in male rats at postnatal days (PD)26 and 32, roughly corresponding to early (1–2 years) and late (9–10 years) human childhood, and in a group of adult rats (14–18 weeks, corresponding to ~22–29 years in humans).

Results
SO and spindle amplitudes generally increased from PD26 to PD32. In parallel, frontocortical EEG spindles increased in density and frequency, while changes in hippocampal ripples remained nonsignificant. The proportion of SOs co-occurring with spindles also increased from PD26 to PD32. Whereas parietal cortical spindles were phase-locked to the depolarizing SO-upstate already at PD26, over frontal cortex SO-spindle phase-locking emerged not until PD32. Co-occurrence of hippocampal ripples with spindles was higher during childhood than in adult rats, but significant phase-locking of ripples to the excitable spindle troughs was observed only in adult rats.

Conclusions
Results indicate a protracted development of synchronized thalamocortical processing specifically in frontocortical networks (i.e. frontal SO-spindle coupling). However, synchronization within thalamocortical networks generally precedes synchronization of thalamocortical with hippocampal processing as reflected by the delayed occurrence of spindle-ripple phase-coupling.
Moringa oleifera leaves ethanolic extract counteracts cortical neurodegeneration induced by aluminum chloride in rats
Authors: Hindawy Rabab Fawzy , Manawy Samia M , Nafea Ola Elsayed , Abdelhameed Abeer A , Hendawi Fatma Fawzi 
Published: March 2024

Abstract

Background
Aluminum, a well-recognized neurotoxin, is implicated in various neurodegenerative disorders. Moringa oleifera (M. oleifera), known as a miracle tree, is utilized as a functional food and nutritional supplement. This study investigates the potential preventive effects of M. oleifera extract on aluminum chloride (AlCl3)-induced cortical neurodegeneration in rats.

Materials and methods
Therefore, 24 adult male Wistar rats were randomly divided into four distinct groups: negative control, M. oleifera extract (MOE), AlCl3, and AlCl3 + MOE. Treatments were administered orally for 28 consecutive days. Cognitive performance, brain oxidative/nitrosative stress, neuroinflammation, apoptotic-cell death, and associated histopathological alterations were assessed.

Results
Our results showed that MOE improved spatial learning and memory, enhanced antioxidant superoxide dismutase enzyme activity, antagonized nitrosative stress, reduced inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6), decreased caspase-3, increased Bcl-2, and facilitated repair of cortical and hippocampal structures.

Conclusions
We concluded that MOE exhibits protective effects against cortical neurodegeneration, making it a promising supplement to counteract aluminum-induced neurotoxic effects.
Tannic acid ameliorates the hazards effect of beryllium induced neuro-alterations and oxidative stress in adult male rats
Authors: Rezk Mohamed M 
Published: March 2024

Abstract

Background
Tannic acid (TA) is one of the most consumed and famous polyphenols with a widespread attention in the medical field according to its unique structural, pharmaceutical, physicochemical, antioxidant and other biological features. A rare study was conducted on the hazard effect of beryllium (Be) on the central nervous system.

Aims
This study aims to show the ability of beryllium to cross the blood brain barrier. Demonstrate the effect of beryllium and tannic acid separately or with each other on brain ions (Na+, K+, Ca++) and on norepinephrine, dopamine, serotonin, finally on the glutathione and malondialdehyde.

Animals grouping
Seventy-two rats were divided into four groups as control, Be, TA, and Be+TA where Be was injected intraperitoneally as 1 mg/Kg b. wt, TA was orally administrated as 5% in aquas solution.

Results
The administration of beryllium showed its ability to cross the blood brain barrier and accumulated in cortex &gt; cerebellum&gt;hypothalamus also, a significant increase in Na+, Ca++ cooperated with a significant decrease in K+ ions content was observed. Norepinephrine, dopamine, and serotonin showed a general significant decrease in their content joined with a significant decrease in glutathione (GSH) and elevation in malondialdehydes (MDA) because of Be intoxication. On the other hands the daily oral administration of tannic acid showed a general significant decrease in Na+, Ca++ ions content parallel with a significant increase K+ also, a non-significant change in the three measured neurotransmitters was noticed.

Conclusion
Tannic acid showed a mitigation effect against Be intoxication which may regarded to the tannic acid antioxidant, chelating effect.
Effects of the Reynolds number on train aerodynamics considering air compressibility: a wind tunnel study
Authors: Huang Zhixiang , Li Wenhui , Chen Li 
Published: March 2024

Abstract
The study of Reynolds number (Re) effects is crucial for optimizing train aerodynamics, enhancing safety and reducing energy consumption of high-speed trains. In this paper, a wind tunnel test was carried out to investigate the influence of Re on the train aerodynamic performance considering the shift of the air compressibility, which has not yet been explored to date. The test was conducted in a low-speed and large-scale tunnel with a stationary floor and the vehicle model was based on a 1/8th scaled train with three units. The Re ranges from 0.75 × 106∼3.12 × 106 by accelerating the uniform wind speed from U = 27.8 m/s to U = 115 m/s with zero-yaw. The Mach number (Ma) of the maximum speed scenario has exceeded 0.3, indicating that the airflow can be considered as being in the compressible range. The results show that the aerodynamic characteristics of high-speed trains exhibit a self-similarity region of Re, which is dependent on the flow velocity. The aerodynamic loads change little when Re ≥ 1.51 × 106, which corresponds to U ≥ 55.6 m/s. Therefore, the compressibility of the airflow within the range up to U = 115 m/s has a negligible effect on aerodynamic loads, and can thus be disregarded. However, the surface pressure significantly decreases when the incoming flow surpasses 0.3 Ma and transitions into a compressible state. While the compressibility has a relatively minor impact on macroscopic aerodynamics, it cannot be overlooked when considering detailed flow field, such as surface pressure.
Too Hard, Too Easy, or Just Right: The Productivity of Schooling and the Match between Child Skill and School Complexity
Authors: Castro Juan F , Villacorta Lucciano 
Published: March 2024

Abstract
This study proposes a novel way of modeling the heterogeneous effects of schooling based on the notion that learning is maximized when the skill of the child matches the complexity of the learning experiences at school. It offers direct evidence about the importance of this match using longitudinal information on test scores and schooling attained by children from Peru, India, and Vietnam. Using data from Peru, it also finds that the relation between the effect of schooling and early childhood skill can follow an inverted-U shape. Increasing early childhood skill will raise the productivity of the school up to the point where it matches school complexity. Further increases in child skill, however, will reduce the productivity of schooling as they will widen the mismatch. If one relates the quality of schools to the amount of learning they produce, this framework predicts that quality gains can be achieved by reducing these mismatches.