bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Interleukin‐Related Genes Signature for Prognosis Prediction in Head and Neck Squamous Cell Carcinoma Patients
Authors: Yang Haojie , Liu Zihao , Tan Zicong , Luo Huimin , Li Qin , Liu Zhongqi , Ji Fengtao 
Published: February 2025

ABSTRACTThis study focused on identifying the interleukin (IL)‐related genes that influence the head and neck squamous cell carcinoma (HNSCC) patients' prognosis and response to anticancer therapy in patients with HNSCC. We developed a risk model that included three gene signatures, IL Enhancer Binding Factor 2 (ILF2), IL 36 alpha (IL36A), and IL10, based on differential expression analysis, survival analysis, Least Absolute Shrinkage and Selection Operator (LASSO) analysis, and Cox regression analysis. We found that the low‐risk group was scored with higher immune cell infiltration, higher expression of human leukocyte antigen (HLA) family genes and immune checkpoint genes, higher cytolytic activity (CYT), tertiary lymphoid structures (TLS), and CD8A/PD‐L1 ratio. In contrast, the high‐risk group was scored with higher tumor immune dysfunction and exclusion (TIDE), which implied worse response to immunotherapy and worse prognosis. The results above indicated that the low‐risk group had stronger antitumor immunity and better responsiveness to immunotherapy. We also observed a significantly enriched pattern of cancer‐related pathways and immune pathways in the comparison of the high‐risk and low‐risk groups. Furthermore, the high‐risk group had higher sensitivity to chemotherapy drugs, which suggested that they might benefit from chemotherapy treatment. Following the results above, we confirmed in HNSCC cell lines and clinical specimens that the level of ILF2 in tumors was significantly higher than that in adjacent tumor tissues. Besides, in vivo and in vitro results both showed that silencing ILF2 might depress tumor growth, invasion, and migration. This study not only provided novel perspectives into the immunological and molecular mechanisms of HNSCC and uncovered IL‐related gene signatures for predicting HNSCC patients' prognosis and response to chemotherapy and immunotherapy, but also preliminarily suggested that ILF2 might be an important target in the treatment of HNSCC.
Is Blockchain Really Good for E‐Platform? A Double‐Edged Sword From Consumer Trust and Channel Cannibalization
Authors: Zhu Xiaoxi , Chen Yu , Ren Minglun , Chu Wei 
Published: February 2025

ABSTRACTThe application of blockchain technology in e‐platforms makes products more reliable and traceable, especially products from third‐party retailers without brand authorization. However, this technology will also intensify the competition between authorized retailers and third‐party retailers. On the other hand, as intermediaries, e‐platforms' profits have also become elusive. We aim to investigate how blockchain technology impacts optimal pricing strategies and profit distribution in a dual‐channel supply chain composed of one manufacturer, one e‐platform, and two e‐tailers. By adopting a Stackelberg game framework, the results show that (1) the e‐platforms may not necessarily benefit from blockchain; only when the commission rate and unit usage cost are both small (or large) enough can the platform achieve higher profit. (2) The application of blockchain can yield extra reputation benefits for third‐party retailer, while the retail prices of both channels may also be higher. (3) The Pareto improvements show that when manufacturer sells products to official retailer and third‐party retailer at different prices, the possibility of successful blockchain implementation increases. (4) When the third‐party retailer shares blockchain usage cost, its optimal channel price rises and demand decreases. For the official retailer, changes in pricing depend on competitive intensity. The manufacturer tends to reduce wholesale price under the strategy, benefiting both e‐tailers and enhancing product competitiveness and supply chain efficiency.
The endocytic pathway for absorption of exogenous RNAs in Verticillium dahliae
Authors: Liu Chuanhui , Cui Chen , Zhou Guanyin , Gao Feng , Zhao Jianhua , Guo Huishan , Jin Yun 
Published: February 2025

AbstractRNAi technologies have been exploited to control viruses, pests, oomycetes, and fungal phytopathogens that cause disasters in host plants, including many agronomically significant crops. Double‐stranded RNA (dsRNA) or small interfering RNA (siRNA) has been applied as a trigger for trans‐kingdom RNAi between hosts and fungi. However, it is unclear what process mediates RNA uptake by fungi. In this study, by using live‐cell imaging, we determined that exogenously synthesized RNA or small RNA (sRNA) was indiscriminately absorbed into Verticillium dahliae, a notorious pathogenic fungus. Moreover, the application of endocytic inhibitors or deletion of endocytic‐related genes reduced RNA uptake efficiency, showing that RNA absorption by fungal cells occurs mainly through endocytosis. In addition, we found that the endocytosed fluorescence‐labeled RNAs were partly colocalized with endosome marker genes. Overall, our research concluded that exogenous RNA could be assimilated by V. dahliae through the endocytic pathway. Unraveling this cytological mechanism underlying trans‐kingdom RNAi holds significant importance, especially considering the fact that RNAi‐based strategies targeting pathogenic fungi are increasingly prevalent in the realm of crop protection.
Uniform General Stability of Piezoelectric Beams With Viscoelastic Finite Memory
Authors: Liao Menglan 
Published: February 2025

ABSTRACTThis paper aims to investigate the asymptotic stability of entirely magnetic effected piezoelectric beams equipped with viscoelastic finite memory. The well‐posedness of the system with finite memory is established by exploiting the semigroup theory. By estimating some suitable Lyapunov functionals and using differential inequality techniques, a general decay result is obtained under the assumptions that the memory kernel does not involve differential inequality.
Osteoarthritis Incidence Trends Globally, Regionally, and Nationally, 1990–2019: An Age‐Period‐Cohort Analysis
Authors: Wang Fei , Cao Yu , Lu Hao , Pan Yuehan , Tao Youping , Huang Shibo , Wang Jiaxu , Huo Litao , Wu Jigong 
Published: February 2025

ABSTRACTObjectivesOsteoarthritis (OA) contributes substantially to global disability. We analysed global and national OA incidence trends and associated factors.MethodsData obtained from the 2019 Global Burden of Disease Study were used to examine 30‐year OA incidence patterns globally and for 204 countries/territories. An age‐period‐cohort (APC) model determined annual percent changes, age‐specific changes, and period/cohort effects.ResultsFrom 1990 to 2019, global OA incidence rose by 21.3 million, with the highest cases in China, India, the United States, and Japan. Incidence was higher in women versus men and peaked at ages 20–24 years, though shifting towards middle‐aged adults. The annual increase was 0.225% (95% confidence interval [CI] 0.157, 0.293) and 0.158% (95% CI: 0.114, 0.201) in high and low socio‐demographic index countries, respectively, with most countries showing increasing incidence. Disadvantageous incidence trends over time and birth cohorts occurred in all regions except middle‐high index countries, which had the lowest increase and declining period effect after 2005.ConclusionOA represents an escalating public health burden, predominantly affecting middle‐aged and elderly populations, and more women than men. Obesity and ageing are major drivers of rising OA incidence. Swiftly implementing policies to prevent modifiable risks and ensure proper treatment access is imperative to mitigate the impact of OA.
Determinants of Healthcare Seeking Patterns in Women With Pelvic Floor Disorders
Authors: Ghandour Rachan , Shen Julia , Zerdan Morgan Bou , Aljamal Sasha , Minassian Vatche A. 
Published: February 2025

ABSTRACTObjectiveTo determine if sociodemographic and health determinants of women with pelvic floor disorders (PFDs) affect health‐seeking behavior, and whether this varies by disease subtype and severity.Materials and MethodsWe conducted a retrospective cohort study of women with PFDs at an academic urogynecology practice between January 2021 and May 2022. Groups were compared across sociodemographic and clinical variables and by pelvic organ prolapse (POP) stage and urinary incontinence (UI) subtype/severity. The primary outcomes of interest were POP stage and UI severity at initial presentation with duration of symptoms as a key determinant. Statistical significance was set at p < 0.05.ResultsThe study included 684 [307 POP (44.9%) and 377 UI (55.1%)] women. Of those with POP, 190 (61.9%) presented with stages I/II and 117 (38.1%) with stages III/IV. In women with UI, 188 (49.9%) had mild–moderate UI and 179 (47.5%) had severe UI. Approximately 76% of women reported PFD symptoms for over 6 months and 47% for 2 years or more upon presentation. Women with advanced‐stage POP had 1.27 increased odds (95% CI: 1.01–1.61) of delaying care for > 24 months, were older (1.07 adjusted OR, 95% CI: 1.03–1.11), and had fewer healthcare visits (0.95 adjusted OR, 95%: CI: 0.91–0.98) in the prior year. Women with severe UI had 1.88 increased odds (95% CI: 1.52–2.35) of delaying care > 24 months, 1.20 odds with government insurance (CI: 1.01–1.32), and 1.18 odds of other comorbidities (CI: 1.02–1.40).ConclusionMost women with PFD reported symptoms for over 6 months at presentation. Women with advanced POP or severe UI were more likely to seek care over 24 months after the onset of symptoms.
Hospital‐to‐Home Transitions for Lung Cancer Patients—A Qualitative Study of Healthcare Professionals' Experiences
Authors: Nilsen Charlotte , Oksholm Trine , Ågotnes Gudmund , Samdal Gro Beate , Ellingsen Sidsel 
Published: February 2025

ABSTRACTAims and ObjectivesTo explore the professional practice of transferring patients with lung cancer from hospitals to their homes through the experiences of healthcare professionals (HCPs) working in hospitals.BackgroundHospital‐to‐home transitions are particularly challenging for vulnerable patients, including lung cancer patients, and could threaten patient safety. There is a need to improve coordination between specialised and community care and to develop knowledge on the practice of transferring patients with lung cancer.DesignA descriptive qualitative design was used. Consolidated criteria for reporting qualitative research (COREQ) were followed for reporting.MethodsSix focus group interviews with nurses and two focus group interviews with physicians at pulmonary medicine units in two hospitals in Norway were conducted. Qualitative content analysis was used to analyse the focus group interviews.ResultsPatients' vulnerability and gratitude motivated HCPs to ensure that patients experienced the best hospital‐to‐home transition. The following obstacles made it challenging to plan for a good hospital‐to‐home transition and to transfer the responsibility for the patient to the municipality: lack of time and routines to attend to the patient's individual needs, lack of established standards for patient information, absence of resources and predictability, and inadequate communication tools for collaborating with the primary healthcare services.ConclusionThe healthcare system does not provide hospital units and HCPs with adequate resources to accommodate the individual needs of lung cancer patients in hospital‐to‐home transitions. HCPs compensate with supplementary initiatives to secure patient safety, but the additional responsibility and tasks leave them overworked.Relevance to Clinical PracticeThe study provides knowledge on lung cancer patients' needs in hospital‐to‐home transitions and how HCPs try to ensure patient safety by compensating for the healthcare system's deficiencies.Public ContributionA reference group comprising one patient representative from the Norwegian Cancer Society and five HCPs with varied relevant backgrounds contributed to the overall design, recruited participants, and provided feedback on the interview guide.
Comprehensive characterization of micropapillary colorectal adenocarcinoma
Authors: Äijälä Ville K , Härkönen Jouni , Mantere Tuomo , Elomaa Hanna , Sirniö Päivi , Pohjanen Vesa‐Matti , Sirkiä Onni , Karjalainen Henna , Kastinen Meeri , Tapiainen Vilja V , Väyrynen Sara A , Pölönen Petri , Ahtiainen Maarit , Helminen Olli , Wirta Erkki‐Ville , Rintala Jukka , Meriläinen Sanna , Saarnio Juha , Rautio Tero , Pylkäs Katri , Seppälä Toni T , Böhm Jan , Mecklin Jukka‐Pekka , Tuomisto Anne , Mäkinen Markus J , Väyrynen Juha P 
Published: February 2025

AbstractMicropapillary colorectal adenocarcinoma is a morphologic subtype of colorectal cancer (CRC) with insufficiently characterized prognostic significance and biological features. We analyzed the histopathological, immunological, and prognostic features of micropapillary adenocarcinoma in two independent CRC cohorts (N = 1,876). We found that micropapillary adenocarcinomas accounted for 4.9% and 6.4% of CRCs in the two cohorts. A micropapillary growth pattern was associated with advanced stage and lymphovascular invasion (p < 0.001), but also with shorter overall survival independent of these factors and other prognostic parameters (Cohort 1: hazard ratio [HR] 1.76, 95% confidence interval [CI] 1.08–2.87; Cohort 2: HR 1.47, 95% CI 1.08–2.00). Multiplex immunohistochemistry and machine learning‐assisted image analysis showed that the micropapillary growth pattern was associated with decreased CD3+ T‐cell and CD14+HLA‐DR+ monocytic cell densities. Molecular features of micropapillary adenocarcinoma were studied using bioinformatic analyses in The Cancer Genome Atlas (TCGA) cohort (N = 629) and validated with optical genome mapping and immunohistochemistry. These analyses revealed that micropapillary adenocarcinomas frequently present with chromosome region 8q24 copy number gain, TP53 mutation, and overexpression of UPK2, MUC16, and epithelial‐mesenchymal transition involved genes, such as L1CAM. These results indicate that micropapillary colorectal adenocarcinoma is an aggressive morphologic subtype of CRC characterized by shorter overall survival, decreased antitumorigenic immune response, and unique molecular features. Our findings support the classification of micropapillary adenocarcinoma as a distinct, high‐risk subtype of CRC, which should be systematically evaluated in patient care. © 2025 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Video Clip Extraction From Fetal Ultrasound Scans Using Artificial Intelligence to Allow Remote Second Expert Review for Congenital Heart Disease
Authors: Day Thomas G. , Venturini Lorenzo , Budd Samuel F. , Farruggia Alfonso , Wright Robert , Matthew Jackie , Zidere Vita , Vigneswaran Trisha , Bo Ilaria , Savis Alex , Wolfenden Jo , Simpson John , Hajnal Jo , Kainz Bernhard , Razavi Reza 
Published: February 2025

ABSTRACTObjectiveTo use artificial intelligence (AI) to automatically extract video clips of the fetal heart from a stream of ultrasound video, and to assess the performance of these when used for remote second review.MethodsUsing a dataset from a previous clinical trial of AI to assist in fetal ultrasound scanning, AI was used to automatically extract video clips of the fetal heart from ultrasound scans of 48 fetuses in which the diagnosis was known: 24 normal and 24 with congenital heart disease (CHD). These, and manually still saved images, were shown in a random order to expert clinicians, who were asked to detect cardiac abnormalities.ResultsThe initial manual scan had a sensitivity of 0.792 and specificity of 0.917 for detecting CHD in this cohort. The addition of second review improved the sensitivity to 0.975 using video clips, which was significantly higher than using still images (0.892, p = 0.002). There was a significant drop in specificity to 0.767 and 0.833 (p < 0.001) for the video and still method, respectively, which were statistically similar to each other (p = 0.117). The median review time was 1.0 min (IQR 0.71) for the still images, and 3.75 min (IQR 3.12) for the AI‐generated video clips.ConclusionAI can be used to automatically extract fetal cardiac video clips, and these can be used for remote second review to improve detection rates. Video clips are superior to still images, but both methods result in a significant drop in specificity.
Compressive behavior and shape memory performance of 4D‐printed metamaterial structures with different Poisson's ratio combinations
Authors: Wei Yuanyuan , Yuan Shaoqing , Shen Xing , Gong Junjie , Hao Wenfeng 
Published: February 2025

AbstractThis paper explores the potential applications of 4D printing technology in the aerospace field, with a focus on the mechanical properties and reusability of honeycomb metamaterials with shape memory characteristics fabricated using shape memory polymers (SMPs). Currently, research on the reusability of SMP‐based metamaterials is limited, particularly regarding the influence of cellular unit geometries on their recovery performance, which remains unclear. To address this gap, this study combines typical cellular units with positive, negative, and zero Poisson's ratio properties into various structures. Through quasi‐static compression experiments, complemented by three‐dimensional digital image correlation (DIC) technology and finite element analysis, the mechanical compression performance and deformation mechanisms of the three structures are compared in detail. The deformation patterns under compression are elucidated, and the influence of geometric shapes on deformation behavior and mechanical response is analyzed. Shape memory recovery experiments, including single‐cycle and multi‐cycle tests, are designed to evaluate the 4D smart recovery performance of the three structures in terms of key metrics such as recovery rate and restoring force. This study systematically characterizes the compressive mechanical properties and shape memory recovery characteristics of honeycomb structures with different Poisson's ratio combinations, providing significant guidance for the research and development of 4D‐printed mechanical metamaterials.Highlights
Metamaterial structures combining unit cells with different Poisson's ratios.
DIC and FEM are used to assess the effects of unit cells on deformation and failure.
ZAZ structure shows superior stiffness and energy absorption in compression.
Evaluate the shape memory performance of SMP under loading conditions.
ZAP structure exhibits more stable cyclic recovery behavior under loading.
Research Progress of Noninvasive Evaluation of Portal Hypertension by Blood‐Based Tests
Authors: Chen Wei , Li Zhi , Zhang Xinjie , Chen Yanan , Hao Shirui , Wang Xiaojuan , Liang Kuopeng , Zhang Jian , Liu Dengxiang , Chen Shubo , Li Jinlong 
Published: February 2025

ABSTRACTPortal hypertension (PH) is a collection of clinical conditions that occur due to an enduring elevation of pressure within the portal venous system, and it is closely linked to the prognosis of liver disease patients. The hepatic venous pressure gradient (HVPG) is considered the diagnostic standard for PH, but its use is limited due to its invasive, costly, and radiological nature. As such, the search for noninvasive diagnostic methods is the focus of researchers worldwide. This review article provides an overview of routine and novel blood test indicators, as well as diagnostic models composed of multiple indicators, in the diagnosis of PH, which was generally diagnosed by HVPG, and also insights into the development of more accurate and simpler diagnostic methods for PH.
Investigation of the Influence of Fiber Stretching on N2‐Pretreated PAN‐Fibers and Development of a Shortened Stabilization Process Meeting the Requirements of the Carbon Fiber Industry
Authors: Liu Ziwen , Akbas Muhsin Mert , Gries Thomas , Kaußen Daniel , Henzler Thomas 
Published: February 2025

ABSTRACTCarbon fibers (CF) are characterized by their excellent mechanical properties and low specific weight. However, due to the high production costs of CF, the application areas of this material are highly limited. A more cost‐effective production of CF through the use of N2‐pretreatment can further increase the spread in mass markets. In the research presented, the influence of fiber stretching on the properties of pretreated Polyacrylonitrile (PAN)‐fibers as well as the resulting carbon fibers is investigated on continuous scale. The investigations show that the fibers can be stretched much more (> 10%) during N2‐pretreatment than in air atmosphere without impairing the mechanical properties of resulting CF. With increasing stretching ratio, the E‐modulus and tensile strength of the pretreated fibers are increasing while the elongation remains on a similar level as the reference carbon fibers. Using this effect, a more efficient stabilization process has been developed in which the first of four stabilizations zones has been skipped. This method ensures high acceptance by the industry, as the process parameters of the other three remaining stabilization zones are untouched. As a result, the thermal conversion time of CF has been reduced by 20% while the mechanical properties of the CF are maintained.
Additive‐Promoted Grignard Reagent Mediated Polymerization With Increased Radical Characteristic Yielding Polystyrene With Narrow Molecular Weight Distribution
Authors: Qiu Can‐Ye , Lai Jia‐Rong , Wang Xin‐Hui , Ye Shi‐Xuan , Sun Xiao‐Li , Wan Wen‐Ming 
Published: February 2025

ABSTRACTGaining polymer with narrow molecular weight distribution (Đ) by efficient living polymerization methods is fundamental and essential in polymer science. Grignard reagent mediated anionic polymerization is capable of low Đ, however, is not suitable for the polymerization of nonpolar monomers like styrene (St). Here, several kinds of additives like lithium chloride (LiCl) and N,N,N′,N′′,N′′‐Pentamethyldiethylenetriamine (PMDETA) are demonstrated as efficient additives that can promote Grignard reagent mediated polymerization of St. Through LiCl‐promoted Grignard reagent mediated polymerization, polystyrene (PS) with manipulated low Đ is successfully achieved under mild conditions with full monomer conversion, by using a series of Grignard reagents (RMgX) in the presence of LiCl. In comparison, no PS can be prepared for Grignard reagents in the absence of additive. Electron paramagnetic resonance reveals that radical characteristic of Grignard reagent is increased in the presence of additive, which eventually enables the successful polymerization of St under mild conditions with full monomer conversion. This work therefore opens a simple additive strategy to promote current living polymerization method and expands the monomer library of Grignard reagent mediated living polymerization, which might cause inspirations to current living polymerization and polymer chemistry.