bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wireless, Battery‐Free, Optoelectronic Diagnostic Sensor Integrated Colorimetric Dressing for Advanced Wound Care
Authors: Cho Seokjoo , Ha Ji‐Hwan , Ahn Junseong , Han Hyeonseok , Jeong Yongrok , Jeon Sohee , Hwang Soonhyoung , Choi Jungrak , Oh Yong Suk , Kim Dahong , Park Su A , Lee Donho , Ahn Jihyeon , Kang Byeongmin , Kang Byung‐Ho , Jeong Jun‐Ho , Park Inkyu 
Published: March 2024

AbstractRecently, addressing various wounds, ranging from skin injuries to pressure and chronic ulcers, has necessitated a more detailed approach to wound condition monitoring aimed at enhancing the patient's quality of life. Although most available wound dressings offer protection and promote the regeneration of wound lesions, they fail to monitor wound progression. To meet this need, this study introduces a pioneering solution: a wireless, battery‐free, optoelectronic diagnostic sensor seamlessly integrated into a colorimetric, pH‐sensitive wound dressing, designed to significantly enhance patient quality of life through improved wound care. Curcumin‐polycaprolactone (C‐PCL) dressing protect the wounds, promote cell regeneration, and possess antimicrobial properties. In addition, the dressing exhibits colorimetric pH‐monitoring capabilities across different wound conditions, enabling individuals without specialized knowledge to assess the status of their wounds. The core innovation lies in the integration of a green light‐emitting diode (LED) and photodiode, which meticulously evaluates color changes from yellow to red of colorimetric dressing, enhance the precision of this user‐friendly colorimetric diagnosis strategy. The integration of wireless battery‐free systems facilitates quantitative and real‐time monitoring of wound data in patients without inconvenience. These innovations will pave the way for rapid wound status evaluation, ensuring timely interventions and optimized care for deteriorating wound conditions.
Scalable and Versatile Metal Ion Solidificated Alginate Hydrogel for Skin Wound Infection Therapy
Authors: Zhang Haomiao , Lu Ye , Huang Lei , Liu Ping , Ni Jun , Yang Tianqi , Li Yihong , Zhong Yu , He Xinping , Xia Xinhui , Zhou Jiancang 
Published: March 2024

AbstractBacterial infections in wounds continue to be a major challenge in clinical settings worldwide and represent a significant threat to human health. This work proposes novel expandable and versatile methods for solidifying sodium alginate (SA) with metal ions (such as Fe3+, Co2+, Ni2+, Cu2+, and Zn2+) to create Metal‐Alginate (M‐Alg) hydrogel with adjustable morphology, composition, and microstructure. It conforms to the wound site, protects against second infection, reduces inflammation, and promotes the healing of infected wounds. Among these hydrogels, Cu‐Alginate (Cu‐Alg) shows excellent sterilization effect and good efficacy against both gram‐positive and gram‐negative bacteria, including multidrug‐resistant (MDR) strains such as Methicillin‐resistant Staphylococcus aureus (MRSA) and Carbapenem‐resistant Klebsiella pneumoniae (CRKP) due to its dual antibacterial mechanisms: contact‐killing and reactive oxygen species (ROS) burst. Importantly, it exhibits low cytotoxicity and biodegradability. This simple and cost‐effective gel‐based system has the potential to introduce an innovative approach to the management of wound infection and offers promising new perspectives for the advancement of wound care practice.
Understanding the Influence of Serum Proteins Adsorption on the Mechano‐Bactericidal Efficacy and Immunomodulation of Nanostructured Titanium
Authors: Martins de Sousa Karolinne , Linklater Denver P. , Baulin Vladimir A. , Dekiwadia Chaitali , Mayes Edwin , Murdoch Billy J. , Le Phuc H. , Fluke Christopher J. , Boshkovikj Veselin , Wen Cuie , Crawford Russell J. , Ivanova Elena P. 
Published: March 2024

AbstractNanostructured surfaces are effective at physically killing bacterial cells, highlighting their prospective application as biomaterials. The benefits of application of mechano‐bactericidal nanostructures as an alternative to chemical functionalisation are well documented, however, the effects of protein adsorption are not well understood. In this work, theoretical and experimental analyses are conducted by studying the adsorption of human serum proteins (HSP) to nanosheet titanium (Ti) and its subsequent effect on the mechano‐bactericidal efficacy toward Staphylococcus aureus and Pseudomonas aeruginosa cells. The nanosheet pattern exhibits enhanced antibiofouling behaviour mantaining high bactericidal efficiency toward both Gram‐negative and Gram‐positive cells in the presence of adsorbed HSP. To ascertain the immunomodulatory response, S. aureus cells are introduced to protein‐conditioned Ti nanosheet surfaces prior to introducing RAW 264.7 macrophages. On the pre‐infected nanostructured surfaces, macrophages exhibit wound healing behaviour with superior activation of M2‐like macrophage polarization and secretion of anti‐inflammatory cytokines. By contrast, macrophages attached to infected smooth surfaces activated the M1‐like polarized phenotype via the high expression of pro‐inflammatory cytokines, indicating persistent inflammation. The outcomes of this work demonstrate the suitability of Ti nanosheets as a potential biomaterial surface whereby the mechano‐bactericidal activity is not compromised by HSP adsorption and, furthermore, positively influenced an anti‐inflammatory immune response.
Emerging Cu‐Based Tandem Catalytic Systems for CO2 Electroreduction to Multi‐Carbon Products
Authors: Qin Qingqing , Suo Hongli , Chen Lijia , Wang Yun‐Xiao , Wang Jia‐Zhao , Liu Hua‐Kun , Dou Shi‐Xue , Lao Mengmeng , Lai Wei‐Hong 
Published: March 2024

AbstractConversion of carbon dioxide (CO2) to valuable chemicals and feedstocks through electrochemical reduction holds promise for achieving carbon neutrality and mitigating global warming. C2+ products are of interest due to their higher economic value. Since the CO2 to C2+ conversion process involves multiple steps, tandem catalytic strategies are commonly employed in the design of electrochemical CO2 reduction reaction (CO2RR) catalysts and systems/reactors. Among the diverse catalysts that are capable of reducing CO2 to CO, Cu stands out for more efficiently further converting CO to C2+ products. In this review, the emerging Cu‐based tandem catalysts and their impact on CO2RR performance, focusing on three positional relationships are summarized. It delves into the integration of tandem catalytic strategies into membrane electrolyzers, utilizing catalyst‐coated substrate (CCS) and catalyst‐coated membrane (CCM) technologies. Several typical examples are presented to illustrate this integration. Finally, the challenges and prospects of applying tandem strategies in the development of CO2RR catalysts/systems, as well as their device‐level implementation are indicated.
Photo‐Induced Electrical Gating with the Inserting of an Interfacial Carrier Blocking Layer for Organic/Graphene Phototransistors
Authors: Yang Weiyu , Fan Sidi , Yang Heng , Li Si , Chen Sizhe , Hu Fengrui , Wang Xiaoyong , Zhang Jing , Liu Xiaolong 
Published: March 2024

AbstractAlthough ultrahigh photoconductive gain is achieved in organic semiconductor‐sensitized graphene phototransistors, the response speed is limited by the photo‐induced carrier injection at the organic/graphene interface. In this work, an insulating hexagonal boron nitride layer is inserted between the organic heterostructure and graphene to block the interfacial carrier transport. Above theh‐BN layer, the organic heterostructure is adopted as the light‐absorbing layer, and the photoresponse of graphene is realized through electrical gating of the atoph‐BN dielectric layer, by the accumulated carriers in the organic heterostructure. Under this “photo‐induced electrical gating” mechanism, the recombination of nonequilibrium carriers takes place only within the organic heterostructure. Furthermore, monolayer perylene‐3,4,9,10‐tetracarboxylic dianhydride (PTCDA) is deposited on graphene before transfer of theh‐BN, by which the interfacial encapsulated bubbles are effectively reduced. As a step further, the trap states are pre‐filled with background light illumination, then the carrier recombination follows the band‐to‐band pathway. Finally, the response time of the organic/h‐BN/graphene phototransistor is reduced to 7.15 ms, and a high photoresponsivity is achieved even though the carrier multiplication is sacrificed, which is reconciled by the improvement of the device quantum efficiency.
Self‐Degradable Photoactive Micromotors for Inactivation of Resistant Bacteria
Authors: Yuan Xiaojiao , Suárez‐García Salvio , De Corato Marco , Muñoz Andrés Camilo , Pagonabarraga Ignacio , Ruiz‐Molina Daniel , Villa Katherine 
Published: March 2024

AbstractPathogenic bacteria pose a significant threat to human health, and their removal from food and water supplies is crucial in preventing the spread of waterborne and foodborne diseases. Recently, silver‐based photocatalytic micromotors have emerged as promising candidates for inactivating pathogenic microbes due to their high antibacterial activity. In this study, the synthesis of photoactive Ag3PO4 micromotors with a well‐defined tetrapod‐like structure (TAMs) is presented using a simple precipitation method. These TAMs autonomously move and release Ag ions/nanoparticles (NPs) through a photodegradation process when exposed to light, which enhances their antimicrobial activity against Gram‐negative (Escherichia coli) and Gram‐positive (Staphylococcus aureus) bacterial strains. Interestingly, different motion modes are observed under different manipulated light wavelengths and fuels. Furthermore, the self‐degradation of TAMs is accelerated in the presence of negatively charged bacteria, which results in higher removal rates of both bacteria, E. Coli and S. aureus. The findings introduce a new concept of self‐degradable micromotors based on photocatalytic components, which hold great potential for their use in antimicrobial applications. This work offers significant implications for materials chemistry, especially in designing and developing the next generation of light‐driven antimicrobial agents.
Alkyl Chain Length Dependent Luminescence and Single‐Component White‐Light Emission from Gemini Aliphatic Quaternary Ammonium Salts
Authors: Li Anze , Tang Saixing , Zhao Zihao , Zhang Qiang , Cai Yusong , Yuan Wang Zhang 
Published: March 2024

AbstractAliphatic quaternary ammonium salts (QASs) with intrinsic photoluminescence (PL) have drawn increasing attention due to the importance of exploring the mechanism of ionic emissive clusters, whereas it remains challenging to clarify structure–property relationships. Here, the effective modulation of photophysical properties of gemini aliphatic QASs (n‐BTADB) is managed by altering the alkyl chain length. Boosted quantum yields (up to 24.6%), prolonged phosphorescence lifetimes (up to 515.2 ms), and varied PL colors are achieved by manipulating the aggregation states of the compounds. Interlaced herringbone packing patterns and strong ionic interactions facilitate the intersystem crossing process and stabilize the triplets. The confluence of varied hydrophobic interactions and chain flexibility results in the fluctuation of phosphorescence lifetimes as the alkyl chain lengthens. Furthermore, the single‐component white‐light emission is obtained in 12‐HBTADB crystals by introducing electron‐rich hydroxyls. These results shed new light on the structure–property relationships of ionic emissive clusters and the rational design of nonconventional ionic luminophores.
An Optimized Human Erythroblast Differentiation System Reveals Cholesterol‐Dependency of Robust Production of Cultured Red Blood Cells Ex Vivo
Authors: Wang Enyu , Liu Senquan , Zhang Xinye , Peng Qingyou , Yu Huijuan , Gao Lei , Xie An , Ma Ding , Zhao Gang , Cheng Linzhao 
Published: March 2024

AbstractThe generation of cultured red blood cells (cRBCs) ex vivo represents a potentially unlimited source for RBC transfusion and other cell therapies. Human cRBCs can be generated from the terminal differentiation of proliferating erythroblasts derived from hematopoietic stem/progenitor cells or erythroid precursors in peripheral blood mononuclear cells. Efficient differentiation and maturation into cRBCs highly depend on replenishing human plasma, which exhibits variable potency across donors or batches and complicates the consistent cRBC production required for clinical translation. Hence, the role of human plasma in erythroblast terminal maturation is investigated and uncovered that 1) a newly developed cell culture basal medium mimicking the metabolic profile of human plasma enhances cell growth and increases cRBC yield upon erythroblast terminal differentiation and 2) LDL‐carried cholesterol, as a substitute for human plasma, is sufficient to support erythroid survival and terminal differentiation ex vivo. Consequently, a chemically‐defined optimized medium (COM) is developed, enabling robust generation of cRBCs from erythroblasts of multiple origins, with improved enucleation efficiency and higher reticulocyte yield, without the need for supplementing human plasma or serum. In addition, the results reveal the crucial role of lipid metabolism during human terminal erythropoiesis.
Design and Development of Transient Sensing Devices for Healthcare Applications
Authors: Janićijević Željko , Huang Tao , Bojórquez Diana Isabel Sandoval , Tonmoy Taufhik Hossain , Pané Salvador , Makarov Denys , Baraban Larysa 
Published: March 2024

AbstractWith the ever‐growing requirements in the healthcare sector aimed at personalized diagnostics and treatment, continuous and real‐time monitoring of relevant parameters is gaining significant traction. In many applications, health status monitoring may be carried out by dedicated wearable or implantable sensing devices only within a defined period and followed by sensor removal without additional risks for the patient. At the same time, disposal of the increasing number of conventional portable electronic devices with short life cycles raises serious environmental concerns due to the dangerous accumulation of electronic and chemical waste. An attractive solution to address these complex and contradictory demands is offered by biodegradable sensing devices. Such devices may be able to perform required tests within a programmed period and then disappear by safe resorption in the body or harmless degradation in the environment. This work critically assesses the design and development concepts related to biodegradable and bioresorbable sensors for healthcare applications. Different aspects are comprehensively addressed, from fundamental material properties and sensing principles to application‐tailored designs, fabrication techniques, and device implementations. The emerging approaches spanning the last 5 years are emphasized and a broad insight into the most important challenges and future perspectives of biodegradable sensors in healthcare are provided.
Inflammatory Microenvironment‐Responsive Hydrogels Enclosed with Quorum Sensing Inhibitor for Treating Post‐Traumatic Osteomyelitis
Authors: Zhang Wenting , Lu Huidan , Zhang Wanying , Hu Jiahao , Zeng Yifei , Hu Huiqun , Shi Liyun , Xia Jingyan , Xu Feng 
Published: March 2024

AbstractNon‐antibiotic strategies are desperately needed to treat post‐traumatic osteomyelitis (PTO) due to the emergence of superbugs, complex inflammatory microenvironments, and greatly enriched biofilms. Previously, growing evidence indicated that quorum sensing (QS), a chemical communication signal among bacterial cells, can accelerate resistance under evolutionary pressure. This study aims to develop a medical dressing to treat PTO by inhibiting QS and regulating the inflammatory microenvironment, which includes severe oxidative stress and acid abscesses, through a reactive oxygen species (ROS)‐responsive bond between N1‐ (4‐borobenzoyl)‐N3‐(4‐borobenzoyl)‐the N1, the N1, N3, N3‐tetramethylpropane‐1,3‐diamine (TSPBA) and polyvinyl alcohol (PVA), and the amino side chain of hyperbranched polylysine (HBPL). Physically enclosed QS inhibitors subsequently exerted the antibacterial effects. This hydrogel can scavenge hydrogen peroxide (H2O2), superoxide anion free radical (·O2−), hydroxyl radicals (·OH) and 2,2‐di(4‐tert‐octylphenyl)‐1‐picryl‐hydrazyl (DPPH) to reduce oxidative stress and inhibit “bacteria‐to‐bacteria communication”, thus clearing planktonic bacteria and biofilms, accelerating bacterial plasmolysis, reducing bacterial virulence and interfering with membrane transport. After in vivo treatment with hydrogel, nearly all bacteria are eliminated, inflammation is effectively inhibited, and osteogenesis and bone repair are promoted to facilitate recovery from PTO. The work demonstrates the clinical translational potential of the hydrogel in the treatment of drug‐resistant bacteria induced PTO.
Complex‐Amplitude Programmable Versatile Metasurface Platform Driven by Guided Wave
Authors: Han Jian‐Qiao , Meng Fan‐Yi , Guan Chunsheng , Wang Cong , Jin Tao , Cai Tong , Ding Chang , Burokur Shah Nawaz , Wu Qun , Ding Xumin 
Published: March 2024

AbstractMetasurfaces have shown unparalleled controllability of electromagnetic (EM) waves. However, most of the metasurfaces need external spatial feeding sources, which renders practical implementation quite challenging. Here, a low‐profile programmable metasurface with 0.05λ0 thickness driven by guided waves is proposed to achieve dynamic control of both amplitude and phase simultaneously. The metasurface is fed by a guided wave traveling in a substrate‐integrated waveguide, avoiding external spatial sources and complex power divider networks. By manipulating the state of the p‐i‐n diodes embedded in each meta‐atom, the proposed metasurface enables 1‐bit amplitude switching between radiating and nonradiating states, as well as a 1‐bit phase switching between 0° and 180°. As a proof of concept, two advanced functionalities, namely, low sidelobe‐level beam scanning and Airy beam generation, are experimentally demonstrated with a single platform operating in the far‐ and near‐field respectively. Such complex‐amplitude, programmable, and low‐profile metasurfaces can overcome integration limitations of traditional metasurfaces, and open up new avenues for more accurate and advanced EM wave control within an unprecedented degree of freedom.
Pressure‐Induced Volumetric Negative Thermal Expansion in CoZr2 Superconductor
Authors: Watanabe Yuto , Arima Hiroto , Kawaguchi‐Imada Saori , Kadobayashi Hirokazu , Oka Kenta , Usui Hidetomo , Matsumoto Ryo , Takano Yoshihiko , Kawahata Takeshi , Kawashima Chizuru , Takahashi Hiroki , Yamashita Aichi , Mizuguchi Yoshikazu 
Published: March 2024

AbstractThe study investigates the thermal expansion and superconducting properties of a CuAl2‐type (tetragonal) superconductor CoZr2 under high pressures. High‐pressure synchrotron X‐ray diffraction is performed in a pressure range of 2.9 GPa < P < 10.4 GPa, and it is discovered that CoZr2 exhibits volumetric negative thermal expansion (NTE) under high pressures. Although uniaxial positive thermal expansion (PTE) along the a‐axis is observed under ambient pressure, it is suppressed by pressure, whereas a large uniaxial NTE along the c‐axis is maintained under the pressure regime. Because of the combination of the suppressed uniaxial PTE along the a‐axis and uniaxial NTE along the c‐axis, volumetric NTE is achieved under high pressure in CoZr2. The volumetric NTE mechanism is based on the flexible crystal structure caused by the soft Co–Co bond, as observed in the isostructural compound FeZr2, which exhibits a uniaxial NTE along the c‐axis. High‐pressure electrical resistance measurements of CoZr2 are performed and confirm superconductivity at 0.03 GPa < P < 41.9 GPa. Because of the coexistence of the two phenomena, volumetric NTE and superconductivity, in CoZr2 under high pressure, coexistence can be achieved under ambient pressure by tuning the chemical composition after the present observation.
Basic Farmland Construction in China: A cost‐effective investment for agricultural productivity and disaster resistance
Authors: Huang Kaixing , Wang Yang , Yan Wenshou , Dong Shuhui 
Published: March 2024

AbstractStarting in 2006, China launched a project to carry out Basic Farmland Construction in 116 representative counties. The objective of this project was to enhance agricultural productivity. China invested 30 billion yuan in this project from 2006 to 2013. Using a difference‐in‐differences approach, this study estimates that Basic Farmland Construction increased per capita agricultural output by 6.3%, crop sown area by 5%, and agricultural mechanization by 7.3%. The total benefits of the project far exceeded the total investments. By incorporating with rainfall shocks, this study finds that the project could mitigate most of the damage from droughts and floods.
Population assessment of the Endangered Kashmir Gray Langur (Semnopithecus ajax, Pocock 1928) using the double‐observer method
Authors: Hameed Shahid , Bashir Tawqir , Ali Mohammad N. , Khanyari Munib , Kumar Ajith 
Published: March 2024

AbstractPrimates are among the most threatened taxa globally, therefore, there is a need to estimate and monitor their populations. Kashmir Gray Langur Semnopithecus ajax is an endangered species for which there is no population estimate. We used double‐observer method to estimate its population size in the Kashmir region of North‐Western Himalaya. We walked 1284 km across 31 survey blocks spanning all three divisions of Kashmir viz., North, Central, and South Kashmir, covering an area of 411 km2. We counted a minimum of 1367 individual langurs from 27 groups. The detection probability for observer 1 (0.719) and observer 2 (0.656) resulted in a population estimate of 1496 (95% confidence interval [CI] 1367–1899) across 30 groups (with a mean group size of 51), giving a density estimate of 3.64 (3.33–4.62) langurs/km². We found double‐observer surveys to be suitable for the population estimation of langurs, and we make recommendations on how to effectively conduct primate surveys, especially in mountainous ecosystems. Our records extend the species distribution range beyond stated by the International Union for Conservation of Nature. Our findings also highlight that the Kashmir Himalaya is a stronghold of the species, where conservation efforts should focus.