bluuebunny/crossref_metadata_2025_split huggingface dataset:
Informed consent of the patient for medical intervention during biomedical research
Authors: Khymych N. , Korchynskyi O. 
Published: February 2024

The article reflects the concept of «informed consent of the patient», indicates the normative regulation and consolidation of this concept, examines the issues of the right to give consent for medical research and the right to refuse to carry it out, analyzes the principle of a person’s free consent in the context of international legal acts, and the relevance of this topic for today is also emphasized.
Human life is a complex and mysterious mechanism that combines physical and spiritual essence. Often, during the entire life path, a person faces various obstacles to his quality existence and comprehensive development. Some of these obstacles already exist in a person from birth, and some may arise during life. In one case, a person can overcome them on his own, in another, he needs the medical assistance of doctors, specialists in the desired direction. More serious obstacles, that is, diseases existing from birth or those that have arisen during life, require comprehensive, targeted treatment, which includes biomedical research or surgical intervention. Important in this aspect is the issue of the consent of a person - a patient to medical treatment and conducting biomedical research, as well as the normative definition and consolidation of such consent.
Having studied, analyzed and researched the issue of «informed consent of the patient for conducting biomedical research», it is possible to come to the unequivocal position that this issue is very relevant and important today. It is mentioned and constantly improved in both international and national legislation. A person repeatedly needs medical assistance during his life.
The right to life and health is guaranteed to everyone by the Constitution of Ukraine and should be unhindered for a person to exercise this right. The process of diagnosis and treatment depends only on the person himself and his free decision. Only with the patient’s consent is this or that study conducted. International legal acts indicate that a person’s failure to consent to medical intervention is considered an interference in his personal private life, a violation of his dignity and freedom.
«Informed consent» includes not only the concept of consent itself, i.e. the free decision of a person, but also an explanation of a specific case or research procedure. And it largely depends on the specialist. Will he be able to convey and explain the patient’s problem, illness, actions correctly, fully and in an accessible form? Yes, free consent is given by a person, but the doctor also influences this decision to some extent. Patients’ freedom in choosing medical care methods is somewhat limited. The patient can choose only among those methods of medical intervention recommended by the attending physician or refuse treatment.
That is why the question of «informed patient consent» will continue to be one of the most debated issues and will repeatedly be an excellent topic for research by young scientists.
Didactic Analysis of Junior High School Students Mathematical Literacy Skill on Space and Shape
Authors: Faizatunnisa  , Tayeb Thamrin , Syah Fazya Auliyah , Khaerani Fahrizah Nurul , Saraswati  
Published: February 2024

It is important for learners to have mathematical literacy skills because it can help learners utilize mathematics in real life, solve problems, assess whether the results obtained make sense, and analyze situations and make conclusions. In the Program for International Students Assessment (PISA), there are four mathematics contents: Space and Shape, Change and Relationship, Quantity, and Uncertainly and Data. The purpose of this study is to identify the learning obstacles experienced by students in the Space and Shape content. This study used a qualitative approach using dedactical design research. With 16 learners, this research was conducted at SMP PST Guppi Samata class IX. The instruments used in data collection are tests and non-tests. The test material consists of questions about mathematical literacy skills level 3, 4, and 6 using flat-sided space building material. The non-test instruments used in collecting data are observation and documentation. Based on the research results, students experience learning difficulties in space and shape content which causes them to be less able to evaluate solutions that have been interpreted. The percentage shows that out of 16 students in class IX, 10% of them have high math ability, 60% have medium math ability, and 30% have low math ability. Efforts can be made to start with the habituation of providing basic calculations so that students can answer test questions correctly. After that, motivation can be given and encourage students to be enthusiastic in understanding the concept of critical thinking in applying the context of the problem to real objects.
Analysis of Students' Learning Obstacles on PISA-based Uncertainty and Data Content
Authors: Kusumayanti Andi , Rahmi Nurfadilah , Hairunnisa Saskia , Amalya Reski Putri , Fauzirah Sri 
Published: February 2024

Mathematical literacy ability is an ability that can be measured in PISA (Programme for International Student Assesment), one of the contents studied is uncertainty and data (Uncertainly and data). This study aims to describe the learning obstacles experienced by students in uncertainty material content and PISA-based data. This research is a type of descriptive research with a qualitative approach using didactical design (Didactical Design Research) didactic situation analysis stage before learning (prospective analysis). This research was conducted at SMP Pesantren Guppi Samata class VIII with a sample of 16 students using a test instrument in the form of 5 points of description questions and non-tests in the form of observation guidelines. Mathematical literacy indicators used in this study are Communication, Mathematising, Representation, Reasoning and argument, Devising strategies for solving problems, Using symbolic, formal , technical language and operations (Using symbolic, formal, technical and operating language), and Using mathematical tools. The results of this study include: 1) difficulties in understanding the problem; 2) Difficulty in formulating problems; 3) Difficulty in understanding the meaning of the problem; and 4) Difficulty in drawing conclusions. So that the obstacles faced by students are ontogenic obstacles and epistemological obstacles.
PENGARUH LITERASI KEUANGAN, MANAJEMEN KEUANGAN DAN PENDAPATAN TERHADAP MINAT INVESTASI EMAS MAHASISWA PENDIDIKAN AKUNTANSI UNIVERSITAS NEGERI SURABAYA
Authors: Oda Firdaus Rafi , Rohayati Suci 
Published: February 2024

Although the form of investment is a precious gold investment, gold investment is part of long-term investment, high risk, many situations, and uncertainty. This is due to the lack of literacy / understanding of gold investment. Thus, this study aims to determine the effects of financial ability, financial management, and interest in money investment. This study uses a quantitative study method. The sample used is 80 student of accounting educational at Surabaya University. Sampling by random sampling method. This survey data was obtained through the distribution of online surveys via Google Forms. The data is processed by multiple regression analysis. The results showed that financial literacy, financial management and income had a simultaneous effect on the interest in gold investment students of the Accounting Education Study Program of Surabaya State University and each variable freely affected the significant effect on the interest in gold investment students of the Accounting Education Study Program of Surabaya State University.
DEVELOPING READING SKILLS TEACHING MATERIALS BASED ON THE SCIENTIFIC APPROACH FOR STUDENT OF MANSYAUL HUDA BOJONEGORO EAST JAVA
Authors: Dessy suryawati  , Abdul Wahab Rosyidi  
Published: February 2024

In accordance with the regulation of the Minister of Education and Culture No. 81 A 2013 Appendix VI regarding aspects of the 2013 Curriculum Scientific Approach which includes: Observing, Questioning, Exploring, Reasoning and Communicating. The learning concepts offered by the 2013 curriculum can be a new hope and challenge for learning Arabic. The end result is an increase and a balance between the ability to become good human beings (soft skills) and humans who have the skills and knowledge to live properly (hard skills) from students which include aspects of attitude, knowledge, and skills competencies. Based on this, the researchers developed teaching materials to support the 2013 Scientific Approach Arabic book used in schools to improve the Reading Skills of 4th grade MI students. Mansyaul Huda.
So the researcher formulates the problem as follows: 1) How is the development of textbooks to improve reading skills with a scientific approach? 2) What is the feasibility of textbooks to improve reading skills with a scientific approach? 3) How is the validity (feasibility) of textbooks to improve reading skills with a scientific approach? . This study aims to 1) describe the process of making textbooks 2) describe the feasibility of textbooks 3) describe the validity of textbooks.
This research uses a development methodology with the ADDIE.. In collecting data the researchers used the method of observation, interviews, documents, questionnaires and tests. In analyzing the data obtained from the questionnaire, the researcher used the linkert scale.
The results of this study are: 1) The researcher applies the steps of the ADDIE method and implements the steps of the Scientific approach in the teaching materials 2) The value of the validity of the textbook is based on a material and language expert questionnaire with a percentage of 68%. design experts achieve a 100%. And the results of the validation of the Arabic language teacher reached a percentage of 92%. This shows that the developed textbook is suitable for use in learning Arabic. 3) This teaching material is said to be effective which can be proven by the t-test value of 10,146 which is greater than 2,056. With these results, it is known that the teaching materials for Arabic books to improve reading skills are good and feasible to be implemented in grade student elementary school IV
Korzyści z zastosowania telmisartanu
Authors: Galewicz Ewa , Lewandowski Jacek 
Published: February 2024

Nadciśnienie tętnicze jest schorzeniem cywilizacyjnym szeroko rozpowszechnionym na całym świecie. Prowadzi do groźnych powikłań narządowych, a samo nadciśnienie i jego powikłania stanowią najczęstszą przyczynę hospitalizacji oraz zgonów. Zgodnie z zaleceniami Europejskiego Towarzystwa Nadciśnienia Tętniczego antagoniści receptora angiotensyny II należą do głównych grup leków wykorzystywanych w terapii nadciśnienia tętniczego.
Telmisartan jest skutecznym i dobrze tolerowanym lekiem hipotensyjnym, wykazującym szereg korzyści klinicznych. Cechuje się wyjątkowym profilem farmakokinetycznym w porównaniu z innymi sartanami. Ponadto jako jedyny lek z tej grupy ma rejestrację do stosowania w profilaktyce incydentów naczyniowo-sercowych u pacjentów z grup podwyższonego ryzyka sercowo-naczyniowego. Telmisartan stanowi ważną alternatywę dla inhibitorów konwertazy angiotensyny, z udowodnioną, podobną skutecznością przy niższym odsetku działań niepożądanych.
ANÁLISE BIBLIOMÉTRICA DA SUSTENTABILIDADE NA INDÚSTRIA 4.0: UMA REVISÃO SISTEMÁTICA
Authors: Diniz Felipe Firmino , Gadelha Abraham Augusto Barbosa , De Souza Jordan Carneiro Martins , Ramos Filho Rivaildo da Silva , Santos Jeovana Jisla das Neves , Gadelha Priscila Maria Barbosa , De Melo Márcio Camargo , Monteiro Veruschka Escarião Dessoles 
Published: February 2024

Objetivo: O estudo foi avaliado à sustentabilidade na engenharia e obrigações as principais revistas e publicações que abordaram esse tema na indústria moderna e consideraram a perspectiva da indústria 4.0.

Lacuna : A sustentabilidade é um tema de grande relevância nos dias atuais, e a indústria busca constantemente novas abordagens para alinhar suas práticas às demandas ambientais e sociais.

Material e métodos: Utilizou o banco de dados Scopus e foram realizadas duas pesquisas abrangendo o tema da sustentabilidade (termos relacionados) e indústria 4.0 (termos relacionados). Na primeira pesquisa, foram utilizados termos de pesquisa relacionados à sustentabilidade (e seus sinônimos). Na segunda pesquisa, foram utilizados termos de pesquisa relacionados à indústria 4.0 (e seus sinônimos) para não perder conteúdos relevantes.

Resultados e discussão: A fase da Indústria 4.0 baseada em tecnologias como os 'Sistemas Ciber-Físicos' e a 'Internet das Coisas'. Em 2018, o número de artigos aumentou significativamente. Em 2019, a quantidade de artigos dobrou em relação ao ano anterior, com um total de 37 artigos. Os resultados ressaltam a importância da indústria 4.0 em um contexto global e o impacto potencial das pesquisas nesse tema.

Implicações da pesquisa: As principais revistas identificadas incluem "Sustainability", "Economics Management and Financial Markets" e "Journal of Self-Governance and Management Economics". O campo da Indústria 4.0 e sustentabilidade é dinâmico e está se tornando cada vez mais central no contexto da pesquisa científica. ANÁLISE BIBLIOMÉTRICA DE
Dwa zakręty III RP
Authors: Piasecki Andrzej 
Published: February 2024

Artykuł jest próbą syntetycznego ukazania dwóch największych kryzysów III Rzeczypospolitej: wydarzeń i zjawisk z pierwszego roku transformacji (1990) oraz z niepokojów społecznych w okresie pandemii (2020-2022). Te tytułowe ,,zakręty’’ historii stały się inspiracją do twórczości filmowej, której egzemplifikacja została w tym tekście zaprezentowana. Autor stara się znaleźć argumenty przemawiające za podjęciem szerszych badań zarówno w kontekście wiedzy o przeszłości jak i o sztuce filmowej. Chodzi mu o trudności w przyswojeniu sobie współczesnych dziejów Polski przez młodzież. A także o to, że najlepszą drogą do wzbudzenia pożądanego zainteresowania jest kinowe arcydzieło (podręcznikowym wzorem są tu ,,Krzyżacy’’). I choć historia III RP nie przyniosła wojen i dramatycznych konfliktów na miarę tysiącletnich dziejów państwa i narodu, to jednak nadzwyczajne stany z tego okresu (np. powódź w 1997 r.) mogą stanowić ważną inspirację dla twórców.
Successful relief of central poststroke pain with BurstDR spinal cord stimulation: A case series
Authors: Busch Nisha L. , Esplin Nathan , Patterson Michael , Tomycz Nestor D. 
Published: February 2024

Background:
Central poststroke pain (CPSP) is a commonly undertreated condition that can negatively impact a patient’s quality of life. The efficacy of spinal cord stimulation (SCS) for the treatment of CPSP is not established due to limited studies.

Case Description:
Here, two patients, ages 42 and 75, sustained strokes resulting in CPSP. After failed medical management, both underwent placement of paddle-lead SCS systems utilizing BurstDR stimulation that successfully resulted in pain resolution.

Conclusion:
Two patients with CPSP were successfully treated with paddle lead SCS with BurstDR programming.
Fungal symptomatic intracranial aneurysm treated with a flow diverting stent: A case report
Authors: Fujimi Yosuke , Ozaki Tomohiko , Izutsu Nobuyuki , Nakajima Shin , Kanemura Yonehiro , Kidani Tomoki , Kawamoto Saki , Nishizawa Naoki , Kobayashi Koji , Fujinaka Toshiyuki 
Published: February 2024

Background:
Intracranial infectious aneurysms (IIAs) are very rare, and fungal aneurysms are infrequently reported. We report a case of an unruptured IIA caused by fungal rhinosinusitis and treated with a flow-diverting stent.

Case Description:
An 81-year-old woman visited the ophthalmology department with impaired eye movement and ptosis and was placed under follow-up. A week later, she also developed a headache; magnetic resonance angiography revealed an aneurysm measuring 2 mm in the C4 portion of the right internal carotid artery. A 3-week follow-up with contrast-enhanced magnetic resonance imaging showed an increase in its size to 10 mm, and a contrast lesion was observed surrounding the right cavernous sinus. The patient started treatment with voriconazole and steroids on the same day. Ten weeks later, despite improvements in inflammation, the size of the aneurysm was unchanged; we, therefore, treated the aneurysm with a flow-diverting stent. Oculomotor nerve palsy improved, and the patient was discharged to a rehabilitation hospital 28 days after the placement, with a modified Rankin Scale of 4. A 1-year follow-up angiogram showed a partial decrease in the size of the aneurysm, with an O’Kelly-Marotta grading scale of B3.

Conclusion:
IIAs grow rapidly, and the risk of rupture is high due to the weakening of the aneurysmal wall. To reduce the risks of rupture and recurrence after treatment, the infection should be treated before inserting a flow-diverting stent. Flow-diverting stent placement may be an effective treatment for IIA once the original infection has been cured.
PENGARUH PENGELUARAN PERKAPITA DAN INDEKS PEMBANGUNAN MANUSIA TERHADAP PRODUK DOMESTIK REGIONAL BRUTO DI JAWA TIMUR
Authors: Fitria Desi Rohmatul , Alfiyan Nur Ahmada Muhamad Agus , Putri Imaretha Vannia , Syahrul Munir Ahmad Alfian 
Published: February 2024

Factors that affect GRDP include per capita expenditure and human development index. The purpose of the study was to determine the effect of per capita expenditure and the Human Development Index or HDI on Gross Regional Domestic Product or GRDP in the East Java region. The data used is sourced from various official sources, and the analysis used is the multiple regression method. The results of the study illustrate a positive and significant relationship between HDI and GRDP, a negative relationship between per capita expenditure and GRDP and a significant influence between HDI and per capita expenditure on GRDP in East Java. Furthermore, the results of the study also identified the dominant variables in influencing the GRDP of a region. Where these variables are HDI variables and per capita expenditure variables. This GRDP is a tool to measure economic growth in the region. When the GRDP of a region increases, it means that economic growth in the region has also increased. These findings can contribute to economic development policies and community welfare in East Java.

Faktor yang mempengaruhi PDRB diantaranya yaitu pengeluaran perkapita dan indeks pembangunan manusia. Tujuan dari penelitian adalah untuk mengetahui bagaimana pengaruh pengeluaran perkapita dan Indeks Pembangunan Manusia atau IPM terhadap Produk Domestik Regional Bruto atau PDRB di wilayah Jawa Timur. Data yang digunakan bersumber dari berbagai sumber resmi, dan analisis yang digunakan yaitu dengan metode regresi berganda. Hasil dari penelitian menggambarkan adanya hubungan positif dan signifikan antara IPM dan PDRB, hubungan negatif antara pengeluaran perkapita dan PDRB serta adanya pengaruh yang signifikan antara IPM dan pengeluaran perkapita terhadap PDRB di Jawa Timur. Selanjutnya dari hasil penelitian juga mengidentifikasi variabel yang dominan dalam mempengaruhi PDRB suatu wilayah. Dimana variabel tersebut adalah Variabel IPM dan variabel Pengeluaran Perkapita. PDRB ini merupakan alat untuk mengukur pertumbuhan ekonomi di wilayah tersebut. Ketika PDRB suatu wilayah mengalami peningkatan artinya pertumbuhan ekonomi di wilayah tersebut juga mengalami peningkatan. Temuan ini dapat memberikan kontribusi pada kebijakan pembangunan ekonomi dan kesejahteraan masyarakat di Jawa Timur.
P146 The Predictive Role of Arterial Stiffness in the Development of Acute Kidney Injury in Patients Undergoing Surgical Aortic Valve Replacement
Authors: Sigala Evangelia , Vlachopoulos Charalambos , Triantafyllou Konstantinos , Katsaros Andreas , Koumallos Nikolaos , Lozos Vasilios , Baikoussis Nikolaos , Kouerinis Ilias , Giakis Nikolaos , Michael Demosthenous , Printzios Dimitrios Terentes , Filis Konstantinos , Tousoulis Dimitrios 
Published: February 2024

Abstract
Purpose/Background/Objectives
Acute kidney injury (AKI) is a serious postoperative complication. Increased arterial stiffness has been shown to be an independent risk factor for cardiovascular events. Our aim was to investigate whether arterial stiffness is a predictor of AKI in patients following surgical aortic valve replacement (SAVR).

Methods
Eighty-four patients (mean age 72 ± 8 years, 34 females) with moderate to severe aortic stenosis undergoing SAVR were included. As indicators of arterial stiffness aortic hemodynamics, carotid-femoral pulse wave velocity (cfPWV) and brachial-ankle pulse wave velocity (baPWV) were assessed prior to surgery. Renal dysfunction was defined when eGFR was below 60 ml/min (n = 28, 33%). AKI was defined using KDIQO criteria.

Results
Twelve patients (14%) developed AKI. There was no significant difference in aortic hemodynamics and cfPWV between the two groups. baPWV significantly correlated with AKI (r = 0.313, p = 0.004). In logistic regression analysis, increase of baPWV per 1 Standard Deviation (Odds Ratio [OR] = 2.76, 95% Confidence intervals [CI]: 1.25–6.11, p = 0.012) and presence of renal dysfunction (OR = 14.93, 95% CI: 2.55–87.32, p = 0.003) were associated with higher risk for AKI even after adjustment for age, gender, systolic blood pressure and diabetes. baPWV was a stronger predictor of AKI than baseline creatinine (Area under the curve [AUC] 0.68, 95% CI: 0.52–0.84, p = 0.05 vs AUC 0.61, 95% CI: 0.46–0.77, p = 0.21; p < 0.05).

Conclusion
baPWV could be considered as a useful predictive biomarker for AKI after SAVR, especially in patients with renal dysfunction prior to surgery.
P149 The Relationship Between Insulin Resistance Scores Parameters and Chemerin in Diabetic and Obese Patients
Authors: Cozma Angela , Fodor Adriana , Negrean Vasile , Sampelean Dorel , Minciuna Ionut , Oltean Monica , Popovici Ionela , Coste Sorina , Dadarlat Alexandra , Pop Dana , Orasan Olga Hilda , Sitar-Taut Adela-Viviana 
Published: February 2024

Abstract
Background
Chemerin represents a recently discovered chemokine influencing adipocyte function, lipolysis, apparently positively associated with insulin resistance.

Purpose
To evaluate the relationship between chemerin-insulin resistance scores in obese/diabetic patients.

Methods
88 patients (66 women), mean age 61.96 ± 10.15. Cardiovascular risk factors (body weight, waist circumference, lipid fractions, smoking, diabetes, hypertension) and chemerin were assessed. Insulin resistance scores were calculated: Homeostatic model assessment (HOMA) = insulin (μU/mL)* glicemia (mg/dl)/405 and Quantitative insulin sensitivity check index (QUICKI = 1/[lg10 (insulin (μU/mL)) + lg10 (glicemia)]. Patients were categorized in obese only (20.5%), diabetics only (12.5%), obese and diabetics (14.8%) and non-diabetics-non obese (52.3%).

Results
35.3% patients were obese, 27.3% diabetics, 79.5% hypertensive, 17% current smokers, 67% dyslipidaemic. The values of chemerin registered in the four groups were as follows: in diabetic + obese patients 7.98 ± 7.22 pg/ml (median 5.2), diabetics only 7.27 ± 5.24 pg/ml (5.6), obese only 8.42 ± 7.56 pg/ml (median 5.8), non-obese-non-diabetics 9.15 ± 7.64 pg/ml (median 7.15). Globally chemerin did not correlate with waist circumference, HDL-cholesterol, LDL-cholesterol, glicemia, insulin, HOMA index or QUICKI index. Going further with analysis, no significant correlations were found between chemerin and HOMA index and QUICKI index in diabetic + obese patients, obese only patients, diabetics only. But, in non-obese-non-diabetics significant correlations were found — between chemerin and glicemia (r = 0.3), HOMA index (r = 0.3, p = 0.03), QUICKI index (r = -0.310, p = 0.037), but not with waist circumference (r = 0.224, p = NS), HDL (r = 0.08, p = NS) or LDL (r = -0.06, p = NS).

Conclusion
Although many things need to be elucidated regarding the chemerin mechanism, it seems very probable to be involved in early insulin resistance.