bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catheter salvage or removal in catheter‐related bloodstream infections with Staphylococcus aureus in children with chronic intestinal failure receiving home parenteral nutrition and the use of prophylactic taurolidine catheter lock solution: A descriptive cohort study
Authors: Demirok Aysenur , Illy David H. C. , Nagelkerke Sietse Q. , Lagerweij Michiel F. , Benninga Marc A. , Tabbers Merit M. 
Published: April 2024

AbstractBackgroundChildren with chronic IF require long‐term home parenteral nutrition (HPN), administered through a central venous catheter. Catheter‐related bloodstream infection (CRBSI) with Staphylococcus aureus is known to be a serious infection with a high mortality rate and risk of complications. A standardized protocol on the management of S aureus CRBSIs in children receiving HPN is lacking. The aim of this study is to evaluate the effectiveness and safety of the current management in an HPN expertise center in the Netherlands.MethodsWe performed a retrospective descriptive cohort study between 2013 and 2022 on children 0–18 years of age with chronic IF requiring long‐term HPN. Our primary outcomes were the incidence of S aureus CRBSI per 1000 catheter days, catheter salvage attempt rate, and successful catheter salvage rate. Our secondary outcomes included complications and mortality.ResultsA total of 74 patients (39 male; 53%) were included, covering 327.8 catheter years. Twenty‐eight patients (38%) had a total of 52 S aureus CRBSIs, with an incidence rate of 0.4 per 1000 catheter days. The catheter salvage attempt rate was 44% (23/52). The successful catheter salvage rate was 100%. No relapse occurred, and no removal was needed after catheter salvage. All complications that occurred were already present at admission before the decision to remove the catheter or not. No patients died because of an S aureus CRBSI.ConclusionCatheter salvage in S aureus CRBSIs in children receiving HPN can be attempted after careful consideration by a multidisciplinary team in an HPN expertise center.
Retrospective analysis of the standardized BARD criteria for acute cholangitis in biliary atresia patients
Authors: Madadi‐Sanjani Omid , Calinescu Ana M. , Rock Nathalie , McLin Valerie A. , Uecker Marie , Kuebler Joachim F. , Petersen Claus , Wildhaber Barbara E. 
Published: April 2024

AbstractObjectivesIn 2022, the Biliary Atresia and Related Diseases (BARD) community reached a consensus for the definition of suspected and confirmed cholangitis for biliary atresia (BA) patients after hepatoportoenterostomy (HPE). This study assessed the new standardized BARD definition in a retrospective, multicenter cohort study.MethodsWe included BA cases managed between 2010 and 2020 at the Hannover Medical School and Geneva University Hospitals' Swiss Pediatric Liver Center. The standardized BARD cholangitis definition assesses four clinical items and four imaging/laboratory items to define cholangitis. The definition was retrospectively applied to all BA cases having presented, according to their physician, cholangitis within the first year after the HPE. The diagnosis defined by the standardized BARD definition was compared with the final clinical diagnosis made by physicians. The Spearman's correlation coefficient was used to test for correlation between diagnoses made by standardized and clinical appreciation.ResultsOf 185 consecutive BA patients, 59 (32%) had at least one episode of cholangitis within the first year after HPE. The correlation between the clinician's impression and the standardized BARD definition was very strong (r = 0.8). Confirmed cholangitis definition coincided with the clinician's impression (2.5 [±0.7]/4 clinical items, 2.6 [±0.5]/4 imaging/laboratory items). For suspected cholangitis, the threshold for diagnosis was lower within the standardized BARD definition (1.1 [±0.3]/4 clinical items, 2.2 [±0.8]/4 laboratory/imaging items).ConclusionsThis first retrospective application of the standardized BARD cholangitis definition reveals a very strong correlation with the physician's assessment before standardization. A prospective study is needed to further refine the standardized definition for cholangitis in BA patients.
What are the short‐ and long‐term abdominal consequences of an omentectomy? A systematic review
Authors: Smit Jan Maerten , Plat Victor D. , Panday Arvind Nannan , Daams Freek , Negenborn Vera L. 
Published: April 2024

AbstractThis review provides an overview regarding the abdominal effects of an omentectomy, with or without extra‐peritoneal reconstructions. In general, reported complication rates were low. Short‐term complications involved ileus, bowel stenosis, abdominal abscess and sepsis (range 0.0%–23%). Donor‐site hernia was mainly reported as long‐term complication (up to 32%) and negligible gastrointestinal complications were observed. However, the level of evidence and methodological quality are quite low with a maximum of 8.5 years follow‐up.
The effect of different alignment strategies on trochlear orientation after total knee arthroplasty
Authors: Klasan Antonio , Anelli‐Monti Victoria , Putnis Sven E. , Neri Thomas , Kammerlander Christian 
Published: April 2024

AbstractPurposeWhen planning and delivering total knee arthroplasty (TKA), there are multiple coronal alignment strategies such as functional alignment (FA), kinematic alignment (KA), mechanical and adjusted mechanical alignment (MA, aMA). Recent three‐dimensional and robotic‐assisted surgery (RAS) studies have demonstrated that KA potentially better restores the trochlear anatomy than MA. The purpose of this study was to compare the restoration of the native trochlear orientation in patients undergoing RAS TKA using four different alignment strategies. It was hypothesised that FA would result in the lowest number of outliers.MethodsThis is a prospective study of 200 patients undergoing RAS‐TKA with a single implant. All patients were analysed for MA and KA prebalancing, and 157 patients received aMA and 43 patients FA with intraoperative balancing. Preoperative transverse computed tomography scans were used to determine the posterior condylar axis (PCA), lateral trochlear inclination (LTI) angle, sulcus angle (SA) and anterior trochlear line (ATL) angle. Implant measurements were obtained using a photographic analysis. Intraoperative software data combined with implant data and preoperative measurements were used to calculate the differences. Outliers were defined as ≥3° of alteration. Trochlea dysplasia was defined as LTI < 12°.ResultsNative transepicondylar PCA had a median of 2°, LTI 18°, SA 137°, ATL 4°. LTI outliers were observed in 47%–60% of cases, with KA < FA < aMA < MA. For ATL, the range of outliers was 40.5%–85%, KA < FA < aMA < MA. SA produced 81% of outliers. Of all median angle values, only LTI when using KA was not significantly altered compared to the native knee.ConclusionThere is a significant alteration of trochlear orientation after TKA, regardless of the alignment strategy used. KA produced the lowest, but a substantial, number of outliers. The uniform design of implants causes the surgeon to compromise on balance in flexion versus trochlear position. The clinical relevance of this compromise requires further clinical investigations.Level of EvidenceLevel II, prospective cohort study.
Hypomethylation‐associated LINC00987 downregulation induced lung adenocarcinoma progression by inhibiting the phosphorylation‐mediated degradation of SND1
Authors: Lai Qi , Wan Yulin , Zhang Yingqian , Huang Yingzhao , Tang Qiuyue , Chen Mei , Li Qian , Ma Ke , Xiao Ping , Luo Cheng , Zhuang Xiang 
Published: April 2024

AbstractDNA methylation, an epigenetic regulatory mechanism dictating gene transcription, plays a critical role in the occurrence and development of cancer. However, the molecular underpinnings of LINC00987 methylation in the regulation of lung adenocarcinoma (LUAD) remain elusive. This study investigated LINC00987 expression in LUAD patients through analysis of The Cancer Genome Atlas data sets. Quantitative real‐time polymerase chain reaction (RT‐qPCR) and fluorescence in situ hybridization assays were used to assess LINC00987 expression in LUAD. The bisulfite genomic sequence PCR (BSP) assay was used to determine the methylation levels of the LINC00987 promoter. The interaction between LINC00987 and SND1 was elucidated via immunoprecipitation and RNA pull‐down assays. The functional significance of LINC00987 and SND1 in Calu‐3 and NCI‐H1688 cells was evaluated in vitro through CCK‐8, EdU, Transwell, flow cytometry, and vasculogenic mimicry (VM) tube formation assays. LINC00987 expression decreased in LUAD concomitant with hypermethylation of the promoter region, while hypomethylation of the LINC00987 promoter in LUAD tissues correlated with tumor progression. Treatment with 5‐Aza‐CdR augmented LINC00987 expression and inhibited tumor growth. Mechanistically, LINC00987 overexpression impeded LUAD progression and VM through direct binding with SND1, thereby facilitating its phosphorylation and subsequent degradation. Additionally, overexpression of SND1 counteracted the adverse effects of LINC00987 downregulation on cell proliferation, apoptosis, cell migration, invasion, and VM in LUAD in vitro. In conclusion, this pioneering study focuses on the expression and function of LINC00987 and reveals that hypermethylation of the LINC00987 gene may contribute to LUAD progression. LINC00987 has emerged as a potential tumor suppressor gene in tumorigenesis through its binding with SND1 to facilitate its phosphorylation and subsequent degradation.
Causes of an extremely low visibility event in Northeast China
Authors: Cao Dianbin , Chen Xuelong , Zhang Qiang , Lin Yanluan , Zhang Qinghong , Ma Yaoming 
Published: April 2024

AbstractAn extreme haze‐fog event occurred during October 20–22, 2013, in Harbin, Northeast China, which lasted for nearly 60 h with local visibility as low as 20 m. However, causes of the extreme haze‐fog formation remain unclear. Through the analysis of in situ data and objective weather circulation classification, it is revealed that high pollutant emissions from biomass burning played a very important role in the extreme event. Stable weather conditions under the circulation type 8 (CT8), marked by weak high‐pressure control, strong inversion (6.55°C), shallow boundary layer depth (<300 m), and high relative humidity (>90%), aided in the accumulation of pollutants and hygroscopic aerosol growth. All of these factors collectively contributed to the extreme haze‐fog formation. The insights derived from this study can improve the predictability of extreme haze‐fog events, and indicate that pollution emissions should be tightly controlled in the adverse meteorological circulation type in Northeast China.
Electroencephalography‐based investigation of the effects of oral desmopressin on improving slow‐wave sleep time in nocturnal polyuria patients (the DISTINCT study): A single‐arm, open‐label, single‐assignment trial
Authors: Torimoto Kazumasa , Gotoh Daisuke , Nakai Yasushi , Miyake Makito , Fujimoto Kiyohide 
Published: April 2024

AbstractAimsTo investigate changes in subjective and objective sleep quality after desmopressin administration in patients with nocturia due to nocturnal polyuria (NP) using electroencephalography (EEG) and the Pittsburgh sleep quality index (PSQI).MethodsTwenty male patients (≥65 years old) with NP participated in this study. The inclusion criteria were nocturnal frequency ≥ 2, NP index (NPi) ≥ 0.33, first uninterrupted sleep period (FUSP) ≤ 2.5 h, serum sodium concentration ≥ 135 mEq/L, and estimated glomerular filtration rate ≥ 50 mL/min/1.73 m2. Participants were given 50 μg of desmopressin to be taken orally once daily before bed. The primary endpoint was the change in the duration of slow‐wave sleep (nonrapid eye movement sleep stages 3 and 4), as evaluated by EEG 28 days from the baseline. The visual analog scale (VAS) was used as an additional indicator of sleep quality.ResultsAnalysis of data from 15 participants (median age: 74.0 [70.5, 76.0] years) revealed that from before to after desmopressin administration, significant decreases occurred in the median nocturnal frequency (3.0 [2.0, 4.0] to 1.5 [1.0, 2.0]) and NPi (0.445 [0.380, 0.475] to 0.360 [0.250, 0.430]). Furthermore, FUSP was significantly prolonged from 120.0 (94.0, 150.0) min to 210.0 (203.8, 311.3) min. Although the VAS scores improved, slow‐wave sleep duration and the PSQI global score showed no significant differences (68.50 [47.50, 75.50] and 48.00 [38.00, 66.50]; 5.0 [5.0, 10.0] and 7.0 [5.0, 9.0] min, respectively).ConclusionOral administration of 50 μg desmopressin improved nocturnal frequency and FUSP in older individuals with NP but did not significantly enhance sleep quality. In older adults, decreased nighttime urinary frequency may enhance quality of life; however, its influence on objective sleep quality may be limited.
A cognitive task analysis of final year nursing students' situation awareness in simulated deteriorating patient events: A mixed methods study
Authors: Walshe Nuala , Drennan Jonathan , Hegarty Josephine , O'brien Sinéad , Crowley Clare , Ryng Stephanie , O'Connor Paul 
Published: April 2024

AbstractAimThe aim of this study was to: (1) use cognitive task analysis to describe final year nursing students situation awareness in recognising, responding and escalating care of deteriorating patients in ward settings; and (2) make recommendations for training and practice.DesignA mixed methods cognitive task analysis with a convergent triangulation design.MethodData collection involved observations of 33 final year nursing students in simulated deteriorating patient scenarios and retrospective cognitive interviews. A process tracing technique was applied to identify the cues to deterioration participants perceived; how cue perception altered as situational demands increased; the extent that participants made connections between perceived cues and reached a situational understanding; and the factors that influenced and constrained participants situation awareness. Qualitative and quantitative findings are woven together and presented using descriptive statistics, illustrative quotations and timeline extractions.ResultsThe median cue perception was 65.4% and 57.6% in the medical and surgical scenarios, respectively. Perception was negatively influenced by incomplete vital sign monitoring as situations escalated; limited physical assessments; passive scanning behaviours; poor task automaticity; and excessive cognitive demands. Incomplete perception, poor cue integration and underdeveloped mental models influenced situational understanding. Escalation calls did not always accurately reflect situations and a reporting mindset was evident. Clinical exposure to deteriorating patients was described as variable and opportunistic.Reporting MethodThe study is reported in accordance with the Good Reporting of a Mixed Methods Study (GRAMMS) checklist.Patient or Public ContributionPatients and public were not involved in this research.
Psychosocial intervention programme based on the needs of women undergoing termination of pregnancy for foetal anomalies: A modified Delphi study
Authors: Wang Ying , Huang Chi , Xie Jiaying , Zeng Lihong , Wang Yaohan , He Yanjuan , Li Ying , Qin Chunxiang 
Published: April 2024

AbstractAimTo construct a psychosocial intervention programme for women diagnosed with foetal anomalies based on their needs in China.DesignA three round‐modified Delphi survey from September to November 2020.MethodsIn Round 1, based on literature review and qualitative interviews, a face‐to‐face meeting with eight taskforce members was conducted to generate the initial intervention indicators. In Round 2 and 3, 15 experts and three stakeholders (women undergoing termination of pregnancy for foetal anomalies) were invited by email to evaluate the importance of the indicators and built the final psychosocial intervention programme.ResultsThe response rate for both two rounds is 100%. The experts' authority coefficient was 0.86. The Kendall W value of the two rounds ranged between 0.191 and 0.339. A needs‐based psychosocial intervention programme was established, including four periods (denial, confirmation, decision‐making and recovery), three needs‐based supports (information, social and acceptance commitment therapy) and 27 intervention indicators. The mean value of the importance of each index was 4.00–5.00. Further research is required to evaluate whether this programme is realistic and effective for the target audiences.
Insurance Status and Access to Otolaryngology Care: National Mystery Caller Study in the United States
Authors: Corbisiero Michaele Francesco , Muffly Tyler M. , Gottman Drew C. , Olson Madeline , Hachicha Yasmine , Garcia‐Creighton Elizabeth , Gallego Natalie , Elsayed Maryam , Ahmed Sophia , Cabrera‐Muffly Cristina 
Published: April 2024

AbstractObjectiveTo investigate potential differences in new patient appointment wait times for otolaryngology care based on insurance types and explore factors influencing these wait times.Study DesignA cross‐sectional audit study, using a “mystery caller” approach, analyzed with a linear mixed Poisson model to adjust for confounding factors.SettingA total of 612 physicians across 49 states and the District of Columbia, representing 6 otolaryngology subspecialties, were included.MethodsOtolaryngology physicians were contacted by mystery callers via telephone with scripted clinical vignettes as patients with either Medicaid or Blue Cross/Blue Shield (BCBS) insurance. Callers requested next available appointment. Wait times for new patient appointments were recorded and analyzed in R using a generalized linear mixed Poisson model.ResultsA total of 1183 of 1224 calls reached a representative. Medicaid patients waited 5.73% longer (P < .001) compared to BCBS patients (IRR: 1.06; confidence interval [CI]: 1.03‐1.09;P < .001), with respective mean wait times of 36.8 days (SE ± 1.6) and 32.4 days (SE ± 1.6). Longer waiting times were also associated with physicians affiliated with universities (P = .001) and certain subspecialties, such as pediatric otolaryngology (P < .001) and neurotology (P = .008). Regional differences were also observed, with specific AAO‐HNS regions showing shorter wait times. The model achieved a conditional R‐squared value of 0.947.ConclusionThis study reveals disparities in wait times for otolaryngology care based on insurance type, with extended wait times for Medicaid beneficiaries. The findings highlight a potential access to care disparity, which begets the need for strategies that ensure equitable access to otolaryngology care and further research to understand the underlying reasons for these potential disparities.
Identifying Opportunities to Deliver High‐Quality Cancer Care Across a Health System: A Clinical Responsibility
Authors: Shah Hemali P. , Cohen Oded , Bourdillon Alexandra T. , Burtness Barbara A. , Boffa Daniel J. , Young Melissa , Judson Benjamin L. , Mehra Saral 
Published: April 2024

AbstractObjectiveWe examined process‐related quality metrics for oral squamous cell carcinoma (OSCC) depending on treating facility type across a health system and region.Study DesignRetrospective in accordance with Strengthening the Reporting of Observational Studies in Epidemiology guidelines.SettingSingle health system and region.MethodsPatients with OSCC diagnosed between 2012 and 2018 were identified from tumor registries of 6 hospitals (1 academic and 5 community) within a single health system. Patients were categorized into 3 care groups: (1) solely at the academic center, (2) solely at community facilities, and (3) combined care at academic and community facilities. Primary outcome measures were process‐related quality metrics: positive surgical margin rate, lymph node yield (LNY), adjuvant treatment initiation ≤6 weeks, National Comprehensive Cancer Network (NCCN)‐guideline adherence.ResultsA total of 499 patients were included: 307 (61.5%) patients in the academic‐only group, 101 (20.2%) in the community‐only group, and 91 (18.2%) in the combined group. Surgery at community hospitals was associated with increased odds of positive surgical margins (11.9% vs 2.5%, odds ratio [OR]: 47.73, 95% confidence interval [CI]: 11.2‐275.86, P < .001) and lower odds of LNY ≥ 18 (52.8% vs 85.9%, OR: 0.15, 95% CI: 0.07‐0.33, P < .001) relative to the academic center. Compared with the academic‐only group, odds of adjuvant treatment initiation ≤6 weeks were lower for the combined group (OR: 0.30, 95% CI: 0.13‐0.64, P = .002) and odds of NCCN guideline‐adherent treatment were lower in the community only group (OR: 0.35, 95% CI: 0.18‐0.70, P = .003).ConclusionQuality of oral cancer care across the health system and region is comparable to or better‐than national standards, indicating good baseline quality of care. Differences by facility type and fragmentation of care present an opportunity for bringing best in‐class cancer care across an entire region.
Psychometric Properties and Concurrent Validity of a 10‐Item Questionnaire for Patients With Vestibular Disorders
Authors: Knapstad Mari Kalland , Heggdal Peder O. , Berge Jan Erik , Nordahl Stein Helge Glad , Goplen Frederik Kragerud 
Published: April 2024

AbstractObjectiveThis study aimed to investigate the psychometric properties and concurrent validity of the Haukeland Dizziness Questionnaire (HDQ‐10), a 10‐item questionnaire designed for simplified assessment of symptom severity and emotional effects in patients with vestibular disorders.Study DesignCross‐sectional study.SettingSecondary referral hospital.MethodsOut of 238 consecutive patients examined for suspected vestibular disease at an otolaryngology clinic, 201 completed the questionnaire. The psychometric properties of the HDQ‐10 were examined by exploratory factor analysis and analysis of internal consistency. Concurrent validity was determined in comparison with the Dizziness Handicap Inventory (DHI), Vertigo Symptom Scale‐Short Form (VSS‐SF), and the Hospital Anxiety and Depression Scale.ResultsThe factor analysis revealed 3 subscales of the questionnaire covering “function,” “unsteadiness,” and “emotion.” The examination of the total scale (α = .866) and its subscales indicated satisfactory psychometric properties. The HDQ‐10 correlated highly with both DHI (r = .732. P < .001) and VSS‐SF (r = .720. P < .001) indicating good concurrent validity.ConclusionThe HDQ‐10 is a 10‐item questionnaire designed for simplified assessment of symptom severity and emotional effects in patients with vestibular disorders. It has satisfactory psychometric properties and good concurrent validity compared to existing dizziness questionnaires.
Study on tensile properties of ultra‐thin‐ply carbon fiber‐reinforced composite laminates under static load
Authors: Ren Mingfa , Liu Yanpeng , Han Yuze , Ren Zhongjie 
Published: April 2024

AbstractThe thinning of carbon fiber‐reinforced composites has been shown to enhance their strength and damage resistance. In this study, cross‐ply and quasi‐isotropic laminate tensile experiments are conducted using composites with ply thicknesses of 24, 55, 75, and 100 μm to investigate the relationship between the strength of laminates and ply thickness. By analyzing the acoustic emission amplitude and energy signals during the loading process of the specimens, the damage evolution of each ply thickness composite under two different stacking methods is studied, revealing the failure mechanisms of the materials. The results show that under both cross‐ply and quasi‐isotropic stacking methods, the ultra‐thin‐ply composites exhibited higher strength. The thickness of ply has a significant influence on the fracture mode of the quasi‐isotropic laminates and the mechanical properties of quasi‐isotropic laminates are more affected by ply thickness than those of cross‐ply laminates.Highlights
Quasi‐isotropic laminate strength is affected more by ply thickness than cross‐ply.
Reduced ply thickness changes fracture mode in quasi‐isotropic laminates.
Ultra‐thin‐ply composites exhibit flat fractures resulting in higher strength.