bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of Cathepsin D in early-stage breast cancer and its prognostic and predictive value
Authors: Alhudiri Inas , Nolan Christopher , Ellis Ian , Elzagheid Adam , Green Andrew , Chapman Caroline 
Published: April 2024

Abstract
Purpose
Cathepsin D is a proteolytic enzyme that is normally localized in the lysosomes and is involved in the malignant progression of breast cancer. There are conflicting results regarding Cathepsin D significance as prognostic and predictor marker in breast cancer. This study aimed to evaluate the expression and prognostic significance of Cathepsin D in early-stage breast cancer.

Methods
Expression of Cathepsin D was assessed by immunohistochemical staining of tissue microarrays, in a large well-characterized series of early-stage operable breast cancer (n = 954) from Nottingham Primary Breast Carcinoma Series between the period of 1988 and 1998 who underwent primary surgery. Correlation of Cathepsin D expression with clinicopathological parameters and prognosis was evaluated.

Results
Cathepsin D expression was positive in 71.2% (679/954) of breast cancer tumours. Positive expression of Cathepsin D was significantly associated with high histological grade (p = 0.007), pleomorphism (p = 0.002), poor Nottingham Prognostic Index (NPI) score (p < 0.002), recurrence (p = 0.005) and distant metastasis (p < 0.0001). Kaplan–Meier analysis showed that Cathepsin D expression was significantly associated with shorter breast cancer-specific survival (p = 0.001), higher risk of recurrence (p = 0.001) and distant metastasis (p < 0.0001). ER-positive tumours expressing Cathepsin D and treated with tamoxifen demonstrated a significantly higher risk of distant metastasis.

Conclusion
Cathepsin D expression significantly predicts poor prognosis in breast cancer and is associated with variables of poor prognosis and shorter outcome. The strong association of Cathepsin D with aggressive tumour characteristics and poor outcomes warrants further research of its potential as a therapeutic target The results also suggest a possible interaction between Cathepsin D and tamoxifen therapy in ER-positive breast cancer which needs further investigation to elucidate the underlying mechanisms.
Association between parity and pregnancy-associated tumor features in high-grade serous ovarian cancer
Authors: Sköld Camilla , Corvigno Sara , Dahlstrand Hanna , Enblad Gunilla , Mezheyeuski Artur , Sundström-Poromaa Inger , Stålberg Karin , Tolf Anna , Glimelius Ingrid , Koliadi Anthoula 
Published: April 2024

Abstract
Purpose
High-grade serous ovarian cancer (HGSC) is the most common ovarian cancer subtype. Parity is an important risk-reducing factor, but the underlying mechanism behind the protective effect is unclear. Our aim was to study if the expression of hormones and proteins involved in pregnancy were affected by the woman’s parity status, and if they may be associated with tumor stage and survival.

Methods
We evaluated expression of progesterone receptor (PR), progesterone receptor membrane component 1 (PGRMC1), relaxin-2, and transforming growth factor beta 1 (TGFβ1) in tumor tissue from 92 women with HGSC parous (n = 73) and nulliparous (n = 19). Key findings were then evaluated in an independent expansion cohort of 49 patients. Survival rates by hormone/protein expression were illustrated using the Kaplan–Meier method. The independent prognostic value was tested by Cox regression, using models adjusted for established poor-prognostic factors (age at diagnosis, FIGO stage, type of surgery, and macroscopic residual tumor after surgery).

Results
HGSC tumors from parous women were PR positive (≥ 1% PR expression in tumor cells) more often than tumors from nulliparous women (42% vs. 16%; p-value 0.04), and having more children was associated with developing PR positive tumors [i.e., ≥ 3 children versus nulliparity, adjusted for age at diagnosis and stage: OR 4.31 (95% CI 1.12–19.69)]. A similar result was seen in the expansion cohort. Parity status had no impact on expression of PGRMC1, relaxin-2 and TGFβ1. No associations were seen with tumor stage or survival.

Conclusion
Tumors from parous women with HGSC expressed PR more often than tumors from nulliparous women, indicating that pregnancies might possibly have a long-lasting impact on ovarian cancer development.
Gamma radiation synthesis of hydroxyethyl cellulose/acrylic acid/CYANEX 471X hydrogel for silver ions capture from acidic nitrate medium
Authors: Masry B. A. , Gayed H. M. , Daoud J. A. 
Published: April 2024

AbstractThe current novelty in this study is to recover silver ion with selective extractant such as cyanex 471X (triisobutylphosphine sulfide) through a clean and green method with high efficiency. Herein, a sustainable hydrogel (HEC/AAc/CX3) was fabricated from triisobutylphosphine sulfide, hydroxyethyl cellulose (HEC), and acrylic acid (AAc) using gamma irradiation polymerization and implanted for the sorption of silver Ag (I) ions from a nitrate acidic medium. Different techniques were employed for characterization of HEC/AAc/CX3 hydrogel such as FT-IR, SEM, XRD, and EDX, before and after the sorption process of Ag(I) ions. Gel content and swelling kinetics ratio of hydrogels at different irradiation doses (10, 20, 30, 40, and 50 kGy) were studied. The Fickian diffusion model results indicate that HEC/AAc/CX3 hydrogel is non-Fickian diffusion, which confirmed that the diffusion and relaxation rates are compatible and were selected for further sorption of Ag(I). The irradiated HEC/AAc/CX3 hydrogels, which contain 0.1 g of cyanex 471X, were employed for batch sorption of 100 mg/L Ag(I) from an acidic solution, and the suggested conditions were pH = 1, time = 60, and v/m = 0.05 L/g, which gives a sorption percentage of 75%. The values of thermodynamic parameters ΔH, ΔG, and ΔS were evaluated as—62.80 kJ/mol, 5 kJ/mol, and -227 J/mol, which indicate that the sorption system was exothermic and nonspontaneous in nature. The maximum adsorption capacity of irradiated HEC/AAc/CX3 for Ag(I) was found to be 12 mg. g−1 at 298 K. Furthermore, the maximum desorption percent of Ag ions from HEC/AAc/CX3 was found to be 70% and achieved with 0.5 M NH4SCN after one desorption cycle. The prepared hydrogel proved its selectivity towards silver ions with facile desorption steps and reusability cycles.
Graphical Abstract
A note on the chemical fate of the DABCO catalyst in amine-catalyzed hypochlorite bleaching of cellulosic pulps
Authors: Lehrhofer Anna F. , Isaza Ferro Estefania , Hosoya Takashi , Hettegger Hubert , Vuorinen Tapani , Rosenau Thomas 
Published: April 2024

AbstractHypochlorous acid bleaching under amine catalysis (Hcat bleaching stage) is an optimized bleaching stage variant that is characterized by working at weakly acidic, near-neutral pH, having high bleaching efficiency, and discharging only very small amounts of chloro-organics. This study addressed the chemical fate of the used 1,4-diazabicyclo[2.2.2]octane (DABCO) catalyst. While literature proposed either homolytic or heterolytic breakage of one ethylene bridge and subsequent release of the resulting fragments as two molecules of formaldehyde, we demonstrated the degradation to proceed by ionic elimination of one ethylene bridge starting from mono-N-chlorinated DABCO. The resulting N-vinyl (enamine) derivative adds water under the release of acetaldehyde and formation of piperazine. The generation of acetaldehyde was experimentally confirmed by 2,4-dinitrophenylhydrazine trapping, directly from the processing liquid. The experimental findings agreed superbly with computations which showed the “acetaldehyde mechanism” to be much favored over the previously proposed pathways under C–C bond cleavage and release of formaldehyde. The results of this study add to a better understanding of the novel Hcat bleaching system.
Graphical abstract
Meta-analysis of Psychotherapy for Autistic Youth
Authors: Rosenau Kashia A. , Kim Junok , Cho An-Chuen Billy , Seltzer Michael , Ugueto Ana M. , Weisz John R. , Wood Jeffrey J. 
Published: April 2024

AbstractIn order to provide more individualized support, it is imperative to further understand the effectiveness of different types of psychotherapy on the clinical areas of need common in autistic youth (Wood et al. in Behav Ther 46:83–95, 2015). Randomized controlled trials of psychotherapy for autistic youth were included if published in English, included random assignment to treatment or control group, required a previous diagnosis of autism, had a mean age of 6–17 years, and provided outcome measure data from both intervention and control groups. A total of 133 measures were coded across 29 studies and included 1464 participants with a mean age of 10.39 years (1.89). A small mean effect size (0.38,95% CI [0.26, 0.47]) was found overall, with the largest effects for cognitive behavioral therapies on autism-related clinical needs (0.81) and overall mental health (0.78). The results show the significant impact of psychotherapy interventions for autistic youth. Additional research should further assess the details of the most effective psychotherapies for each area of clinical need.
Differences in Well-Being at School Between Young Students With and Without a Refugee Background
Authors: Leeuwestein Hanneke , Kupers Elisa , Boelhouwer Marieke , van Dijk Marijn 
Published: April 2024

AbstractStudents with a refugee background are a vulnerable group in education. Adverse experiences and unsafe circumstances that they encounter prior, during and after their flight can place a great burden on their mental health and psychological well-being. Little is known about the psychological well-being of young refugee students in kindergarten and early years of primary school. The current study examined the psychological well-being of 4- to 8-year-old students with a refugee background residing in the Netherlands (n = 136), compared to Dutch peers without a refugee background (n = 406). Primary school teachers completed three questionnaires which assessed multiple indicators of their students’ psychological well-being: Strengths and Difficulties Questionnaire (SDQ), Social-Emotional Questionnaire (SEV) and Risk and Protective factors Trauma Observation School Situations (RaPTOSS). In line with the hypothesis, results showed overall lower psychological well-being among refugee students compared to non-refugee students. Teachers observed more total difficulties in socio-emotional functioning, anxious and mood disturbing behavior, ADHD symptoms, problematic social behavior and post-traumatic stress symptoms (small effects), and less developed trauma protective factors and prosocial behavior (medium effects) among students with a refugee background compared to their non-refugee peers. However, the findings also demonstrated that half of the refugee students did not have any scores that fall in the clinical range of the psychological and behavioral problems assessed. The results underline the need to promote protective factors such as positive self-image, self-regulation skills, safety and relations in the classroom and prosocial behavior among students with a refugee background.
Associations Among Sleep, Emotional Eating, and Body Dissatisfaction in Adolescents
Authors: White Megan L. , Triplett Olivia M. , Morales Nuria , Van Dyk Tori R. 
Published: April 2024

AbstractThe literature on adolescent sleep has shown a bidirectional relationship between sleep difficulties and altered eating habits, including emotional eating. However, it is unclear if this relationship is related to preexisting body concerns, or if poor sleep is the prime contributor to emotional eating patterns. This study therefore seeks to examine body dissatisfaction as a moderator of the sleep-emotional eating relationship in an at-risk sample. Adolescents (N = 106) presenting for overnight polysomnography self-reported on time-in-bed, insomnia, body dissatisfaction, and emotional eating. Less time-in-bed was correlated with a greater desire for thinness and greater insomnia severity was related to overall emotional eating and eating in response to anxiety, anger, and frustration and in response to depression. Moderation analyses revealed that the relationships between time-in-bed and eating in response to feeling unsettled (b =  −.002, 95% CI[− .003,  − .001], p < .005) and eating in response to anxiety, anger, and frustration (b =  −.01, 95% CI[− .01,  − .001], p < .05) were exacerbated by worse body dissatisfaction. Optimizing sleep may attenuate the risk for disordered eating, particularly for adolescents with high body dissatisfaction.
Investigating Educators’ and Students’ Perspectives on Virtual Reality Enhanced Teaching in Preschool
Authors: Rapti Sophia , Sapounidis Theodosios , Tselegkaridis Sokratis 
Published: April 2024

AbstractRecent developments in technology have introduced new tools, such as virtual reality, into the learning process. Although virtual reality appears to be a promising technology for education and has been adopted by a few schools worldwide, we still do not know students’ and educators’ opinions, preferences, and challenges with it, particularly in relation to preschool education. Therefore, this study: (a) analyzes the preferences of 175 children aged 3 to 6 years regarding traditional teaching compared to enhanced teaching with virtual reality and (b) captures educators’ perspectives on virtual reality technology. This evaluation of virtual reality took place in 12 Greek preschool classrooms. A combination of quantitative and qualitative methods were used for data collection. Specifically, regarding the qualitative data collection, the study included semi-structured interviews with the participating educators, oriented by 2 axes: (a) preschoolers’ motivation and engagement in virtual reality activities, and (b) virtual reality technology prospects and difficulties as an educational tool in a real class. Regarding the quantitative data collection, specially designed questionnaires were used. Bootstrapping was utilized with 1000 samples to strengthen the statistical analysis. The analysis of the students’ responses indicated a statistically significant difference in preference in favor of virtual reality enhanced teaching compared to a traditional method. Statistically significant differences were also observed regarding gender. Furthermore, based on the educators’ answers and comments, difficulties were encountered initially but eventually, virtual reality was regarded as an effective approach for educational purposes. However, concerns arose among educators as to whether this technology could adequately promote preschoolers’ cooperative skills.
The evolution of non-financial report quality and visual content: information asymmetry and strategic signalling: a cross-cultural perspective
Authors: Di Chiacchio Laura , Vivian Ben , Cegarra-Navarro Juan , Garcia-Perez Alexeis 
Published: April 2024

AbstractThe increasing stakeholders’ scrutiny requires firms to communicate their non-financial performance to signal their commitment to sustainability. Building on the intention-based view and signalling, legitimacy and institutional theories, this study investigates whether corporate efforts to reduce information asymmetry and enhance their legitimacy led to higher quality and more transparent non-financial reporting practices. This study analyses reports from German, UK and Chinese companies over 14 years. It carries out quantitative and qualitative analysis of textual and visual content to evaluate disclosure density and accuracy of non-financial reports. The findings show limited progress in terms of the density and accuracy of the information disclosed by businesses since 2005. Also, they reveal cultural specificities in the reporting and approach to corporate social responsibility, along with a tendency to “create an appearance of legitimacy” by organisations. This study adds to the literature by studying the use of visual elements in non-financial reports. Moreover, it calls for strict policies and guidelines for the reporting of environmental and social issues by organisations. In particular, the inappropriate use of visual contents, the failure to provide quantitative information and managerial orientations show the need for completeness, transparency, and balance of information in reporting guidelines and regulations. The lack of authenticity and quality of the reports jeopardises the very purpose of non-financial reporting eroding trust in the system by all relevant social and economic stakeholders.
The Relational Analysis of Belief Ascriptions and Schiffer’s Puzzle
Authors: Rinner Stefan 
Published: April 2024

AbstractUsing a variant of Schiffer’s puzzle regarding de re belief, I recently presented a new argument against the so-called Naive Russellian theory, consisting of the following theses: ($$NR_{1}$$

N

R
1

) The propositions we say and believe are Russellian propositions, i.e., structured propositions consisting of the objects, properties, and relations our thoughts and speech acts are about; ($$NR_{2}$$

N

R
2

) Names (and other singular terms) are directly referential terms, i.e., the propositional content of a name is just its referent; ($$NR_{3}$$

N

R
3

) A sentence of the form ‘A believes/disbelieves that S’ is true in a context c if and only if the referent of A in c believes/disbelieves the proposition expressed by S in c. In this paper, I will argue that my variant of Schiffer’s puzzle is not only a problem for the Naive Russellian theory, but for every theory of belief ascriptions entailing ($$NR_{3}$$

N

R
3

). Such theories are also called relational analyses of belief ascriptions. Here the main alternative to a Neo-Russellian theory, consisting of ($$NR_{1}$$

N

R
1

) and ($$NR_{2}$$

N

R
2

), is a Fregean theory, according to which the propositions we say and believe are Fregean propositions, i.e., structured propositions consisting of ways the objects, properties, and relations our thoughts and speech acts are about are presented to the speaker or agent. I will argue that such variants of the relational analysis are committed to principles very similar to the principles used by my Schiffer puzzle. Concluding, I will discuss Fregean and Neo-Russellian alternatives to the relational analysis, and I will argue that, although there are Neo-Russellian alternatives to the relational analysis which provide a solution to my variant of Schiffer’s puzzle, there seem to be no such Fregean alternatives.
When massified higher education meets shrinking birth rates: the case of South Korea
Authors: Jung Jisun 
Published: April 2024

AbstractMost discussions of higher education research in the last four decades have focused on expanding higher education, including increasing access, equity, and quality. However, the growth of higher education enrolment has slowed in many advanced higher education systems since the achievement of massification, with enrolment declining more dramatically in some systems than in others. South Korea (hereafter Korea), which has experienced one of the most dynamic evolutions in higher education, was recently reported to have the lowest birth rate among OECD countries, and its drastic demographic changes are significantly affecting all aspects of higher education. This paper describes Korea’s shrinking youth population and its impact on different stakeholders in Korean higher education. It also reviews and evaluates Korea’s policies in reaction to the declining population in higher education. The findings of this paper provide policy implications for countries that will experience similar challenges associated with declining enrolment in the years to come, including institutional closures, mergers, and strategies to maintain competitiveness.
Assessing the potential of C-phycocyanin as a natural colorant for non-alcoholic carbonated beverages
Authors: Ghosh Tonmoy , Rawat Ismail , Bala Kiran , Mishra Sandhya , Bux Faizal 
Published: April 2024

AbstractThe multibillion-dollar carbonated beverage industry is currently facing questions from health-conscious consumers over negative health effects of such beverages. Decreasing consumption trends have forced companies to look for healthier choices for their products. C-phycocyanin CPC, a bright blue cyanobacterial pigment with anti-oxidant and other health benefits has been proposed as a candidate in edible drinks. We found that CPC is stable in a wide pH and temperature regime. Reaction kinetics for 12 weeks at 4 °C in non-alcoholic carbonated beverages (B1-B4) showed that B3 (sweetened, ~30 % degradation) best preserved CPC integrity while B1 (non-sweetened, ~87 % degradation) was ineffective. Other beverages (sweetened) could preserve ~ 49 % CPC integrity. Behnajady-Modirshahla-Ghanbary and first order kinetic models explained CPC degradation with and without preservative (sucrose), respectively. The ’consume-by’ times suggest possible refrigeration from ~ 13 hours to 27 days for various CPC-containing beverages. Results suggest CPC could be filter-sterilized and added to non-alcoholic beverages before being packaged in cans or tetra packs to avoid light exposure.
Graphical abstract
Kinetic Inductance Traveling Wave Amplifier Designs for Practical Microwave Readout Applications
Authors: Giachero A. , Vissers M. , Wheeler J. , Howe L. , Gao J. , Austermann J. , Hubmayr J. , Nucciotti A. , Ullom J. 
Published: April 2024

AbstractA Kinetic Inductance Traveling Wave Amplifier (KIT) utilizes the nonlinear kinetic inductance of superconducting films, particularly niobium titanium nitride (NbTiN), for parametric amplification. These amplifiers achieve remarkable performance in terms of gain, bandwidth, and compression power and frequently approach the quantum limit for noise. However, most KIT demonstrations have been isolated from practical device readout systems. Using a KIT as the first amplifier in the readout chain of an unoptimized microwave SQUID multiplexer coupled to a transition-edge sensor microcalorimeter, we see an initial improvement in the flux noise [1]. One challenge in KIT integration is the considerable microwave pump power required to drive the non-linearity. To address this, we have initiated efforts to reduce the pump power by using thinner NbTiN films and an inverted microstrip transmission line design. In this article, we present the new transmission line design, fabrication procedure, and initial device characterization—including gain and added noise. These devices exhibit over 10 dB of gain with a 3 dB bandwidth of approximately 5.5–7.25 GHz, a maximum practical gain of 12 dB, and typical gain ripple under 4 dB peak to peak. We observe an appreciable impedance mismatch in the NbTiN transmission line, which is likely the source of the majority of the gain ripple. Finally, we perform an initial noise characterization and demonstrate system-added noise of three quanta or less over nearly the entire 3 dB bandwidth.
A Psychoneuroimmunological Reading of Jane Austen’s Persuasion in the Context of Bodily Aging
Authors: Riestra-Camacho Rocío , Enamorado Miguel Ángel Jordán 
Published: April 2024

AbstractJane Austen normally avoids discussing appearance throughout her works. Persuasion constitutes the exception to the rule, as the story focuses on the premature aging experienced by her protagonist, Anne Elliot, seemingly due to disappointed love. Much has been written about Anne’s “loss of bloom,” but never from the perspective of psychoneuroimmunology, the field that researches the interrelation between psychological processes and the nervous and immune systems. In this paper, we adopt a perspective of psychoneuroimmunology to argue that Austen established a connection between psychological distress, specifically lovesickness, and the development of early senescence signs, and vice versa, since the recovery of love is associated with happiness and physical glow. From a gender perspective, we discuss how Austen brightly reflected these interrelationships through the story of Anne, when the latest psychoneuroimmunological research has actually shown that women age earlier than men as a consequence of psychological turmoil.