bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pi‐Gm LINKAGE: EVIDENCE FOR LINKAGE IN MALES BUT NOT IN FEMALES AND FOR AN EFFECT OF THE S ALLELE OF THE Pi SYSTEM
Authors: Chapuis‐Cellier C. , Verdier M. , Lepetit J. C. , Fudenberg H. H. , Arnaud P. 
Published: April 2007

SummaryLinkage between the Pi (alpha1‐antitrypsin) and Gm (immunoglobulin heavy chain) loci was studied in thirty‐four families including forty‐one informative parents and 142 children. In females, the results did not provide evidence for linkage (posterior probability of non‐linkage 0.98). In contrast, in males, there was strong evidence for linkage (peak lod 3.9 at 0= 0.18, posterior probability of linkage 0.98). The two populations appeared to be significantly different (0.001 < P < 0.01) with respect to the heterogeneity criterion of Morton. In addition, the effect of the possession of the S allele (associated with significantly decreased serum alpha1‐antitrypsin levels) was studied in fifteen informative parents and fifty‐three children of the same group. No evidence for or against linkage was found in females, but in males close linkage between Pi S and Gm was demonstrated (peak lod 7.7 at 0= 0.05, posterior probability of linkage 0.9999). These data indicate significant linkage between Pi and Gm in males but not females and close linkage between the Pi S and Gm markers in males.
GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAEMOGLOBIN: I. DEMONSTRATION OF SEPARATE GENETIC CONTROL OF THE RESPONSES TO THE α‐ AND β‐SUBUNITS BY IN VITRO LYMPHOCYTE PROLIFERATION
Authors: Krco J. , Kazim A. L. , Atassi M. Z. , David C. S. 
Published: April 2007

SummaryThese studies were undertaken to analyse the genetic control of the immune response to an oligomeric protein and the role of individual subunits in the regulation of the response. Human adult haemoglobin (Hb) was selected as a model for these studies because it is a well‐characterized protein and its antigenic structure is being determined in our laboratories. Mice of various congenic strains were immunized with Hb and the lymph node cells from Hb‐primed mice were challenged in vitro with Hb, and its α‐chain and β‐chains as well as an appropriate control antigen. Lymphocyte proliferation was determined by 3H‐thymidine incorporation. The data collected indicated that mice of the H‐2b and H‐2d haplotypes were high responders while H‐2k, H‐2s, H‐2q and H‐2j haplotype mice were low responders to Hb. Studies with H‐2 recombinant strains indicated that the immune response to Hb and its subunits is determined by genes in the I‐A subregion and the D end of the H‐2 complex. The significance of these findings in terms of control and regulation of the overall response to native Hb are discussed.
H‐2D ANTIGENS RELEASED BY THYMOCYTES AND CELL ADHESION
Authors: Curtis A. S. G. , Davies M. D. J. 
Published: April 2007

SUMMARYThe identity and complete purification of mouse Thymocyte Interaction Modulation Factor (T IMF) is described. Use of silver‐stained PAGE methods shows that previous methods of purification yield preparations containing two protein or glycoprotein bands. T IMF activity from H‐2k mice can be bound to 15.5.5 monoclonal antibody columns (anti H‐2 Dk) but not to 11.4.1 columns (anti H‐2 Kk). The activity can be recovered from 15.5.5 columns and runs on PAGE as a single band at approximately 34,000 Daltons. This evidence together with previous evidence relating the activity to H‐2 D locus argues that T IMF is a soluble H‐2 D antigen fragment equivalent to a papainized H‐2 fragment. Additional evidence is presented on an improved method of assay of T IMF activity, on its inactivation by enzymes and serine‐esterase inhibitors and of its effect on syngeneic leucocytes and macrophages. It is also shown that T IMF is not appreciably toxic for cells.
LACK OF ASSOCIATION OF THE IMMUNE RESPONSE TO RAGWEED ANTIGEN E, Ra 3 AND Ra5 WITH THE HLA SYSTEM
Authors: Blumenthal*, M. N. , Yunis, E. , Gleich, G. , Mendell, N. , Stoy*, P. , And G. Walsh* , Roitman‐Johnson* B. 
Published: April 2007

SUMMARYOne hundred and sixty‐five individuals with ragweed rhinitis and asthma were studied. The associations between the HLA system and: Ra3 skin‐test response, Ra3 RAST, Ra3/antigen E skin‐test reactivity ratio, Ra5 skin‐test response, Ra5 RAST, Ra5/antigen E skin‐test reactivity ratio, serum IgE levels, antigen E skin‐test response, and antigen E RAST were studied. In addition, the influence of the serum IgE levels of these immune parameters were evaluated. No highly significant associations were noted.
GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAEMOGLOBIN:
Authors: Krco, C. J. , Kazim, A. L. , And M. Z. Atassi , David C. S. 
Published: April 2007

SUMMARYMice of independent haplotypes and several recombinant inbred strains were immunized with highly purified preparations of either the α‐chain or β‐chain subunit of human adult haemoglobin. Cells from the sensitized lymph nodes were challenged in vitro with the appropriate subunit (or in some cases both chains) and cell proliferation assessed by 3H‐thymidine incorporation. Mice of the H‐2b and H‐2d haplotypes were high responders to α‐chain while mice of the H‐2f, H‐2j, H‐2k, H‐2r, H‐2s, H‐2u, and H‐2v haplotypes were low responders. The low responsiveness of B10.A(4R) and B10.MBR and the high responsiveness of B10 indicated that the Ir gene(s) determining responsiveness to the α‐chain subunit resides in the I‐A subregion of the mouse major histocompatibility complex. Mice of the H‐2d, H‐2f, and H‐2s haplotypes were high respoders and H‐2b, H‐2f, H‐2q, and H‐2u haplotype mice were low responders to β‐chain. H‐2k, H‐2p, H‐2r, and H‐2v haplotype mice were intermediated responders to β‐chain. The low responsiveness of B10.S(8R) and B10.TL and the high responsivenes of B10.S(9R) mapped the Ir gene(s) to β‐chain to the I‐A subregion. Data collected from challenging high responder cells with both subunits indicated that α‐chain and β‐chain do not crossreact. These results are discussed in reference to earlier observations suggesting that the low responsiveness of some strains of mice to priming and challenging using the intact haemoglobin molecule might be due to a negative regulatory influence mediated by one of the subunits. In the absence of this influence these mice would respond normally.
C4 HAPLOTYPE PRODUCTS AND PARTIAL INHIBITION OF ANTI‐RODGERS SERA
Authors: Nordhagen R. , Olaisen B. , Teisberg P. , Gedde‐Dahl Jr T. , Thorsby E. 
Published: April 2007

SUMMARYElectrophoretic and serologic investigations of C4 in serum samples from a family material, showed that a weak, or partial, inhibition of anti‐Rg sera, was an inherited property of some of the C4 haplotype products. The weak Rg activity was strongly, but not absolutely associated with the C4 FI and C4 I haplotypes.
THE ASSOCIATION OF AN HLA‘ASTHMA‐ASSOCIATED’ HAPLOTYPE AND IMMEDIATE HYPERSENSITIVITY IN FAMILIAL ASTHMA
Authors: Brady R. E. , Glovsky M. M. , Opelz G. , Terasaki P. , Malish D. M. 
Published: April 2007

SUMMARYFifty‐seven members from ten families in which one parent and at least one child have asthma were studies with dilutional skin tests and RAST to grass pollens after determination of HLA haplotypes. We found no direct evidence for linkage of a hypothetical asthma locus with HLA or for a significant association of asthma with HLA haplotypes. Linkage between the HLA loci and a gene or genes which allow for the expression of clinical asthma could neither be proven nor disproven due to the small sample size. All of the asthmatic children had positive dilutional skin tests and RAST, suggesting that atopic asthma may be genetically controlled by the HLA chromosome (chromosome 6). Nonetheless, determination of the histocompatibility antigens can increase the value of predictive risk analysis for asthma. Such a determination may be important in the early identification of a child born to a family with atopic asthma.
OOCYTES REACT WITH ANTIBODY DIRECTED AGAINST H‐2 BUT NOT Ia ANTIGENS
Authors: Heyner Susan , Hunziker R. D. 
Published: April 2007

SUMMARYMouse oocytes at the dictyate stage were tested for the presence of H‐2 antigens and Ia antigens, by means of indirect immunofluorescence. Oocytes reacted positively with NIH alloantisera, but were negative with anti‐Ia region alloantisera. Results with monoclonal antibodies indicate very low antigen density on oocytes.
MURINE LYMPHOCYTE ALLOANTIGENS: THE Ly‐4 LOCUS
Authors: McKenzie T. A. Potter, I. F. C. , Cherry M. C. 
Published: April 2007

SUMMARYThe murine Ly‐4 locus is further described with the definition of both Ly‐4.1 and 4.2 specificities and the demonstration of linkage of H‐3 on Chromosome 2. As has been found for several other Ly‐specificities, both Ly‐4 specificities are absent from the thymus, but are found on peripheral T and B cells, with B cells having the greatest antigen expression. The expression of both Ly‐4 specificities was influenced by an H‐2‐linked gene, mapping in or near the H‐2D locus.
PREPARATION AND PROPERTIES OF ANTISERA TO Mph‐1, THE MOUSE MACROPHAGE ALLOANTIGEN
Authors: Archer J. R. , Dewar* A. Edna 
Published: April 2007

SUMMARYMph‐1 is an alloantigen demonstrable on mouse peritoneal macrophages. Two lines, B10M.I and C.I, have been bred for use with strains I/StDa or BALB/c to produce appropriate alloantisera. Optimal immunization procedures for production of anti‐Mph‐1.2 (the common antigen) are described. Antisera against Mph‐1.1 have so far been obtained only erratically.Antisera show complement dependent cytotoxicity against normal peritoneal macrophages and cultured blood monocytes but have no obvious effect on peritoneal lymphocytes or cultured blood neutophils. Absorption studies show that cell for cell normal peritoneum has about fifteen times more antigen than lymph node, spleen, liver or bone marrow and at least eighty times more than thymus. We were unable to use the antiserum to cause passive enhancement of skin grafts in mice.
IMMUNOGLOBULIN ALLOTYPES AND IMMUNE RESPONSE TO MENINGOCOCCAL POLYSACCHARIDES A AND C
Authors: Pandey J. P. , Ambrosch F. , Fudenberg H. H. , Stanek G. , Wiedermann G. 
Published: April 2007

SummarySerum samples were collected from 113 healthy Caucasian volunteers before and after vaccination with meningococcal polysaccharides (MPS) group A and group C. Antibodies to MPS group A and group C were measured and sera were typed for several Gm and Km (1) allotypes. A significant association was found between the Gm 1,3,17; 5,13,14,21 phenotype and low immune responsiveness to MPS group A. These results suggest the possible existence of an immunoglobulin allotype‐linked immune suppression (Is) gene(s) in man.
Gm ALLOTYPES AND IgG SUBCLASS LEVELS IN IRAQI ARABS
Authors: Shakib F. , James K. , Barr D. 
Published: April 2007

SummaryThe study of the distribution of IgG subclasses in a group of Iraqi Arabs has revealed marked elevation in the levels of IgG3 associated with low levels of IgG1. Furthermore, individuals homozygous for the G3m(b) marker were found to have significantly higher levels of IgG3 than individuals heterozygous for this marker. Results are discussed in relation to other similar reports.
THE IMMUNE RESPONSE OF ALLOPHENIC MICE TO THE SYNTHETIC POLYMER GLØ*: III. ALLOTYPE ANALYSIS OF ANTI‐GLØ ANTIBODY
Authors: Gorcyca D. E. , McIvor‐Nayeri Judith L. , Maurer P. H. , Warner Carol M. 
Published: April 2007

SUMMARYAllophenic mice were produced by aggregating 8‐cell embryos from a low responder (CBA) and a high responder (DBA/1) strain to the synthetic amino acid polymer GLø. In some strains of mice, the immune response to this polymer is controlled by two genes, α and β, which map to the IE/C and IA subregions of the H‐2 complex, respectively. The CBA strain is α+β ‐ whereas the DBA/1 strain can be considered to be α+β+. These two strains also differ in immunoglobulin allotype: CBA is allotype a and DBA/1 is allotype c. Eight CBA DBA/1 allophenic mice were immunized with GLø. Four of the mice gave a high secondary response to the polymer. The alloptype of the angibody from these mice was determined by affinity chromatography, and it was found that only allotype c was present. This means that all of the antibody was produced by high responder DBA/1 cells. Thus, there is no evidence for the cooperation of histoincompatible cells in the mounting of an immune response by allophenic mice.
ASSOCIATION OF THE C2‐DEFICIENCY GENE (C2*QO) WITH THE C4A*4, C4B*2 GENES
Authors: Hauptmann, G. , Tongio, M. M. , Goetz, J. , Mayer, Simone , Fauchet, R. , Sobel, A. , Griscel, C. , Berthoux, F. , Rivat, C. , Rother Urusula 
Published: April 2007

SUMMARYC4 typing in thirteen homozygous C2‐deficient patients and in a family with heterozygous C2 deficiency showed a strong association of the C2‐deficiency gene (C2*QO) with the relatively rare C4A* C4B*2 haplotype.
INHIBITORY ACTIVITIES OF SUBSTANCES PRESENT IN PLANT SEEDS AND FRUITS AGAINS ANTI‐LEWIS AGGLUTININS
Authors: Yamamoto S. 
Published: April 2007

SUMMARYThirty‐six species of higher plants were found to contain substances in their fruit or seed extracts, which were heat stable and inhibitory for anti‐Lea agglutinin. Both preparations partially fractionated from Sophora japonica and Euonymus Sieboldiana were also slightly inhibitory for anti‐Leb agglutinin.
BASILEA KAPPA LIGHT CHAINS OF RABBIT IMMUNOGLOBULINS
Authors: Dubiski S. , Charpentier L. , D'Agostaro G. 
Published: April 2007

SUMMARYImmunogenetics of the Basilea allotype were investigated. It was shown that the Basilea gene is controlled at a locus identical with, or closely linked to, the Ab kappa allotypic locus. Basilea‐positive molecules have been physically separated by immunoabsorption from molecules carrying the λ chain markers, c7 and c21. Injection of newborn Basilea homozygotes with anti‐Basilea immune serum results in suppression of the synthesis of Basilea‐positive molecules, but does not affect the synthesis of the λ chain, or of the heavy chain allotypic markers. Allotype‐suppressed Basilea homozygotes do not recognize either the Basilea allotype or the kappa isotype as ‘self’ and make anti‐Basilea and anti‐kappa antibody upon immunization with Basilea antigen. The specificity of this antibody was identical with that of a heterologous anti‐kappa immune serum raised in a goat and made specific by absorption with purified lambda material. These results prove that Basilea gene products are of kappa isotype and are controlled at the Ab allotypic locus.
THE DETECTION OF PUBLIC Ia ANTIGENS ON THE SURFACE OF B6‐C.H‐2b m 1 2 BLAST CELLS
Authors: Michaelides Mary , McKenzie I. F. C. 
Published: April 2007

SUMMARYThe B6‐C.H‐2bm12 (bm12) strain has previously been described as a spontaneously occurring mutant wherein the parental C57BL/6 Iab specificities (Ia.3, 8, 9, 15 and 20) are absent or reduced in amount. To further characterize the bm12 mutant the antigenic phenotype of LPS‐activated bm12 blast cells was determined with monoclonal and conventional anti‐Ia antibodies. By direct testing and absorption the public Ia.8, 9 and 15 specificities were readily detected on both parental C57BL/6 and mutant bm12 blast cells, and the amounts of these antigens on activated bm12 cells were similar to or less than those found on C57BL/6 blast cells. The findings demonstrate that the Ia‐1 mutation has not resulted in an absolute loss of these specificities, but has altered their expression, or their accessibility to antibody on resting cells. By contrast, the private Ia. 20 specificity and another specificity (designated Iab) could not be detected on bm12 blast cells.
ANOTHER EXAMPLE OF HAEMOPOIETIC (TWIN) CHIMAERISM IN A SUBJECT UNAWARE OF BEING A TWIN
Authors: Bird G. W. G. , Wingham June , Nicholson G. S. , Battey Diana A. , Koster H. G. , Webb Tessa 
Published: April 2007

SUMMARYA fourth human blood group chimaera studied in Birmingham is an example of haemopoietic (twin) chimaerism in which the subject was unaware of being a twin. Chimarerism was discovered during routine antenatal serological investigation in which it was shown that the proposita has two red cell populations, one of the rhesus genotype rr, and the other R1r. Further studies showed that she has two populations of lymphocytes, one with the female karyotye, 46XX, and the other with the male karyotype, 46XY. Skin fibroblasts were all 46XX.
H‐2 INFLUENCE ON THE SEVERITY OF MOUSE HEPATITIS VIRUS TYPE 3‐INDUCED ACUTE DISEASE
Authors: Sabolovic Nicole , Wellman‐Bednawska Maria , Oth D. 
Published: April 2007

SUMMARYSusceptibility to the acute disease induced by MHV3 injection has been found to be quantitatively influenced by the H‐2 haplotype of semi‐susceptible mouse strains. Seric levels of cobalt‐activated acylase, which correlates with clinical status, were also under H‐2 influence.
RATS HIGHLY SUSCEPTIBLE TO EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS OBTAINED BY CROSSING RATS FROM STRAINS WITH LOW SUSCEPTIBILITY
Authors: Källén Bengt 
Published: April 2007

SUMMARYBy crossing and back‐crossing three strains of rats, Brown‐Norway, Fischer, and PVG, none of which is definitely susceptible to experimental autoimmune encephalomyelitis (EAE), it is possible to obtain fully susceptible animals. Genetic analysis indicates the presence of Ir‐genes in at least two of the strains (Fisher and PVG) related to the AgB complex, and genes of ‘resistance’ located on another chromosome. The latter appear to be different in the three strains; also the BN strain, which perhaps does not carry an Ir‐EAE gene, apparently carries effective genes of resistance.
GENETIC CONTROL OF THE IMMUNE RESPONSE TO MYOGLOBIN: IX. OVERCOMING GENETIC CONTROL OF ANTIBODY RESPONSE TO ANTIGENIC SITES BY INCREASING THE DOSE OF ANTIGEN USED IN IMMUNIZATION
Authors: Young C. R. , Atassi M. Z. 
Published: April 2007

SUMMARYPreviously, it was reported that the immune response to myoglobin (Mb) was under genetic control, with the response to each site being under separate Ir‐gene control. Here we have investigated the effect of antigen dose on the control of the antibody response to the five antigenic sites of sperm‐whale Mb to determine whether or not the overcoming of genetic control by antigen dose has a uniform effect on all five antigenic sites.The antibody response to sperm whale myoglobin (Mb) and its five antigenic was measured in the following inbred strains of mice, C57BL/6J, AKR and SWR/J. These strains of mice are low responders to Mb following immunization with 50 μg, responding only to site 4. After immunization with 200 μg Mb:C57BL/6J mice are high responders to Mb and respond to antigenic sites 1, 3,4 and 5; AKR mice are high responders to Mb and respond to antigenic sites 1 and 4; SWR/J mice are high responders to Mb and respond to all five antigenic sites. It was concluded that the genetic control of the immune response to Mb and its synthetic antigenic sites is dependent on antigen dose. Also, these studies have enabled us for the first time to separate the response to site 1 from the response to site 2 and thus have conclusively established that sites 1 and 2 are controlled by separate Ir‐genes.
TWO MONOCLONAL ANTIBODIES DETECTING HIGH FREQUENCY ANTIGENS ABSENT FROM RED CELLS OF THE DOMINANT TYPE OF Lu (a‐b‐) Lu:‐3
Authors: Knowles R. W. , Bai Y. , Lomas, C. , Green C. , Tippett P. 
Published: April 2007

SUMMARYTwo monoclonal antibodies, M447 and H86, were produced which recognize previously unidentified red cell antigens whose expression is inhibited by the In(Lu) geen. M447 and H86 react with all red cell samples from adults except those from the dominant type of Lu(a‐b‐) Lu:‐3; they also fail to rect with cord red cell samples.
HLA, AND THE RESPONSE TO TREATMENT WITH γ‐TYPE ENDORPHINS IN SCHIZOPHRENIA
Authors: Jongh B. M. De , Verhoeven W. M. A. , van Ree J. M. , Wied D. De , van Rood J. J. 
Published: April 2007

SUMMARYIn order to investigate whether genetic factors are involved in the response of schizophrenic patients to treatment with γ‐type endorphins, we typed 32 Dutch schizophrenic patients for the HLA‐A, ‐B, ‐C and ‐DR antigens. The total patient group showed an increase of HLA‐Bw4 and HLA‐Cw1. A subgroup of 20 paranoid patients showed an increase of HLA‐Cw1 and a significant heterogeneity for the HLA‐C locus. In 16 patients who responded moderately or markedly to treatment with γ‐type endorphins, an increase of HLA‐B15/Cw3 and a decrease of HLA‐B17 were found as compared to 16 patients with no or a slight response. Moreover, HLA‐B15 was particularly increased in those patients who responded markedly and remained free of psychotic symptoms for a period of at least 6 months after treatment with γ‐type endorphins (RR = 24.6, Puncorr.= 0.0015).Our results suggest that genetic factors coded for within the HLA region are associated with paranoid schizophrenia, and that HLA‐B15/Cw3 is associated with a marked and prolonged response to treatment with γ‐type endorphins.
PRECISE MAPPING OF THE GENE FOR Ly ‐21. 2 ON THE 7th CHROMOSOME
Authors: Kennard Janis , Meruelo D. 
Published: April 2007

SUMMARYWe have recently described a murine lymphocyte alloantigen, Ly‐21.2, and showed that the gene which controls Ly‐21.2 expression is linked to albinism on the 7th chromosome. In order to map the gene more precisely, we have studied the linkage of Ly‐21.2 with two other genetic markers on the 7th chromosome, the electrophoretic variant of the β chain of haemoglobin and glucose phosphate isomerase, in (A/J × C57BL/10)F2 mice. The results of these 3‐point cross studies show that the gene encoding Ly‐21.2 maps 27 units distal to albinism.
FURTHER ANALYSIS OF THE Ly‐6 GENETIC REGION : ISOLATION AND CHARACTERIZATION OF CELL LINES WITH ALTERED EXPRESSION OF Ly‐6 ANTIGENS
Authors: Horton M. A. , O'Brien H. A. W. , Takei F. 
Published: April 2007

SUMMARYThe identity, or close linkage, or a series of murine alloantigens encoded by the Ly‐6 genetic region has been well documented. We have investigated the relationship between two component antigens, Ly‐6.2 and H9/25, by generating and characterizing a number of variant cell lines which have altered antigen expression, isolated by chemical mutagenesis and immunoselection of BW5147 lymphoid cells. Cloned cell lines, selected by either antiserum, show loss of both antigens and also fail to express Thy‐1, a further genetically linked, but unrelated determinant. The relevance of these findings to furthering understanding of the structure of the Ly‐6 region and regulation of antigen expression is discussed.
NATURAL AGGLUTININS TO HIDDEN MEMBRANE COMPONENTS IN THE BOVINE ERYTHROCYTES
Authors: Sellei J. 
Published: April 2007

SUMMARYDigestion of bovine erythrocytes (BE) with trypsin (Tr) or chymotrypsin (CTr) revealed Tr and CTr specific' receptor respectively. These receptor reacted with all the isologous, including the autologous, sera. The titres of agglutinability varied for the Tr‐digested BE from 1:2 to 1:64 and from zero to 1:128 for the CTr‐digested BE. However, the variation between the members of nomozygous twin pairs (MZ) in no case exceeded ±2 score units, the error limits. Agglutination of the CTr‐digested BE gave with the PHA lection very similar, (r= 0.964) results to that which was ontained with the isologous sera.The titre of agglutinins showed concordance in all the sera of MZ pairs when tested against the neuraminidas‐digested human erythrocytes and the Tr or CTr‐digested BE. Their variance due to differences varied between MZ pairs from 60.4 to 74.3%.