bluuebunny/crossref_metadata_2025_split huggingface dataset:
Type 2 diabetes mellitus and post-colonoscopy colorectal cancer: clinical and molecular characteristics and survival
Authors: Boysen Mette L. , Troelsen Frederikke S. , Sørensen Henrik T. , Erichsen Rune 
Published: March 2024

Abstract
Purpose
Studies suggest that patients with type two diabetes mellitus (T2D) may be at increased risk of post-colonoscopy colorectal cancer (PCCRC). We investigated clinical and molecular characteristics and survival of T2D patients with PCCRC to elucidate how T2D-related PCCRC may arise.

Methods
We identified T2D patients with colorectal cancer (CRC) from 1995 to 2015 and computed prevalence ratios (PRs) comparing clinical and molecular characteristics of CRC in T2D patients with PCCRC vs. in T2D patients with colonoscopy-detected CRC (dCRC). We also followed T2D patients from the diagnosis of PCCRC/dCRC until death, emigration, or study end and compared mortality using Cox-proportional hazards regression models adjusted for sex, age, year of CRC diagnosis, and CRC stage.

Results
Compared with dCRC, PCCRC was associated with a higher prevalence of proximal CRCs (54% vs. 40%; PR: 1.43, 95% confidence interval [CI] 1.27–1.62) in T2D patients. We found no difference between PCCRC vs. dCRC for CRC stage, histology, and mismatch repair status. The proportion of CRCs that could be categorized as PCCRC decreased over time. Within one year after CRC, 63% of PCCRC vs. 78% of dCRC patients were alive (hazard ratio [HR] 1.85 [95% CI 1.47–2.31]). Within five years after CRC, 44% of PCCRC vs. 54% of dCRC patients were still alive (HR 1.44 [95% CI 1.11–1.87]).

Conclusion
The increased prevalence of proximally located PCCRCs and the poorer survival may suggest overlooked colorectal lesions as a predominant explanation for T2D-related PCCRC, although altered tumor progression cannot be ruled out.
Human health risk assessment of metal-contaminated soils in Sydney estuary catchment (Australia)
Authors: Birch Gavin , Wang Xiaoyu , Liu Enfeng 
Published: March 2024

AbstractSydney estuary catchment supports the largest city in Australia and provides essential eco-social and environmental services; however, the region has been influenced by extensive anthropogenic modification. Soil metal concentrations in the catchment had been studied previously; however, the current investigation was designed to determine the risk posed by these contaminants to human health. Soil metal concentrations were higher than observed in most global capitals and increased substantially in the south and south-east of the catchment and close to the central business district. Road-side soils and road dust contained the highest concentration of metals in the catchment. Lead in catchment soils was closely related to traffic density and sourced from the historic use of Pb in petrol. A human health assessment indicated that soil Cd, Ni and Zn posed no non-carcinogenic risk (NCR), or carcinogenic risk (CR) for children, or adults in Sydney estuary catchment and that Cu and Cr may pose minor NCR for children. Vehicle-related Pb raised the greatest human health risk in catchment soils and may pose NCR at 32% and 4.3% of sites for children and adults, respectively. Inconsistent analytical techniques used in CR and NCR evaluations produce incomparable assessments and a consistent` methodology is suggested to improve interpretation. Human health risk may well be higher than commonly calculated due to pollutants present in urban soil not being included in assessments.
Stern–Gerlach, EPRB and Bell Inequalities: An Analysis Using the Quantum Hamilton Equations of Stochastic Mechanics
Authors: Beyer Michael , Paul Wolfgang 
Published: March 2024

AbstractThe discussion of the recently derived quantum Hamilton equations for a spinning particle is extended to spin measurement in a Stern–Gerlach experiment. We show that this theory predicts a continuously changing orientation of the particles magnetic moment over the course of its motion across the Stern–Gerlach apparatus. The final measurement results agree with experiment and with predictions of the Pauli equation. Furthermore, the Einstein–Podolsky–Rosen–Bohm thought experiment is investigated, and the violation of Bells’s inequalities is reproduced within this stochastic mechanics approach. The origin of the violation of Bell’s inequalities is traced to the the non-local nature of the velocity fields for an entangled state in the stochastic formalism, which is a result of a non-separable probability distribution of the considered particles.
Genetic diversity of maize resources revealed by different molecular markers
Authors: Chňapek Milan , Balážová Želmíra , Špaleková Andrea , Gálová Zdenka , Hromadová Zuzana , Číšecká Lucia , Vivodík Martin 
Published: March 2024

AbstractMaize (Zea mays L.) is the third most important cereal crop in the world because of its nutritional value and industrial benefits. Molecular markers are used mainly by the breeders to study the genetic variability of genotypes and its application in the breeding process. Two types of molecular markers, 10 random amplified polymorphic DNA (RAPD) primers and 10 start codon target (SCoT) primers, were assayed to determine the genetic diversity of 25 Slovak maize lines and 25 maize cultivars. A high level of polymorphism was found with both RAPD and SCoT markers, which was confirmed by high average polymorphism information content (PIC) values using both techniques. The efficiency of individual marker techniques in the detection of genotype diversity can be compared by calculating the marker index (MI), detecting diversity index (DDI), discriminating power, resolving power (RP) and other indices. A higher MI (11.788), DDI (2.358) and RP (53.08) value was achieved by the SCoT technique compared to the RAPD method. Three joint dendrograms and PCoA plots constructed based on RAPD, SCoT and both methods combined confirmed the unambiguous separation of maize lines and cultivars from each other. The results obtained from the RAPD and SCoT analysis can be used for the selection of potentially suitable biological sources for further marker-assisted breeding.
High-speed electrolyte jet 3D printing of ultrasmooth and robust Cu microelectrodes
Authors: Gu Wending , Marianov Aleksei , Jiang Yijiao 
Published: March 2024

AbstractElectrochemical 3D printing technology built on computer numerical control platforms has enabled multi-dimensional and multi-scale manufacturing of various metal materials through layered electrochemical deposition. Compared to thermal 3D printing technology, electrolyte meniscus-confined 3D printing can manufacture Cu microstructures with fewer defects and smoother surfaces. In the meantime, it is still susceptible to unstable liquid–solid-air interfaces, low deposition rates, and limited printing geometry. This work combined jet electrochemical deposition with a portable 3-axis platform to develop a cyclic high-speed electrolyte jet (HSEJ) 3D printer. It offers a faster deposition rate of 53.4 µm/h when printing ultrasmooth Cu microelectrodes with surface average roughness down to 1.1 nm and microhardness of 3.3 GPa which is much higher than the best result of 2.4 GPa obtained by the other ECD methods. It is identified that the fluctuation of cathode current density plays a crucial role in defining the nucleation morphology on the Cu surface, while the cathode current efficiency is a reliable indicator to assess the deposition localization by reflecting the variation of diffusion percentage. HSEJ 3D printing provides a sustainable pathway for the facile recycling of waste cables into high-grade metal microelectronics with controllable surface morphology and 3D dimensions.
Graphical Abstract
Values and National Identification in Minority and Majority Youth: Longitudinal Multi-Study Findings
Authors: Benish-Weisman Maya , Daniel Ella , Elizarov Einat , Sverdlik Noga , Titzmann Peter F. 
Published: March 2024

AbstractCollective identification is vital for adolescents, fostering well-being and connection, but scant attention has been given to drivers of national identification and their contextual variations in youth. To address this, two longitudinal studies examined how values, as guiding goals defining what individuals consider important in their lives, relate to the trajectory of national identification in majority and minority youth. Study 1 (N = 568; Mage = 16.24, SD = 0.71) and Study 2 (N = 678; Mage = 13.78, SD = 0.73) focused on majority youth (Jewish-Israelis), while Study 2 also included minority (Arab citizens of Israel). The findings highlight values as important motivators of national identification over time. Conservation values, emphasizing the preservation of the status quo and a preference for stability, were prominent motivators for the majority of adolescents. In contrast, power values, which center around climbing the social ladder and accumulating wealth, held greater significance among their minority counterparts; however, both sets of values correlated with increased national identification. The discussion touches on motivations underlying national identification, their contextual diversity, and implications for future studies.
Influence of a changing wave climate on the quality and morphometry of the stalked barnacle Pollicipes pollicipes (Gmelin, 1789), along the coasts of NW Iberia
Authors: Peñas-Torramilans Raquel , Outeiral Raquel , Santiago José , Vázquez Elsa , Weidberg Nicolas 
Published: March 2024

AbstractWave climate is shifting over the last decades along the Atlantic coasts of Europe ultimately driven by large-scale patterns of atmospheric variability forced by anthropogenic global warming. Changes in wave height and surf zone orbital currents are hypothesized to drive marked shifts in the shape of intertidal organisms such as the stalked barnacle Pollicipes pollicipes, whose quality and market price are known to decrease non linearly with the peduncle length: width ratio S. This study evaluates wave trends in NW Iberian Peninsula, using the Spanish Port System 2006–2020 SIMAR wave hindcast. On the other hand, trends in stalked barnacle morphology and quality are estimated from 26 sites at the management regions of Baiona and A Guarda between 2011 and 2020. Results show evidence of temporal changes in barnacle quality and, especially, morphometry caused by simultaneous shifts in winter wave induced orbital currents. Because of the non linear relationship between S and the high quality threshold, large increases in S are usually translated to small reductions in quality. However, we identified a tipping point around S = 2.4 that if surpassed can lead to great drops in barnacle quality. In addition, changes in wave forcing will have different effects at each extraction site, as trends in wave climate are decoupled from barnacle morphometry at steeper sites sheltered from the predominant wave direction. In conclusion, this knowledge could be applied to develop site specific barnacle harvesting strategies based on annual wave climate forecasts.
Graphical abstract
Quantile ratio regression
Authors: Farcomeni Alessio , Geraci Marco 
Published: March 2024

AbstractWe introduce quantile ratio regression. Our proposed model assumes that the ratio of two arbitrary quantiles of a continuous response distribution is a function of a linear predictor. Thanks to basic quantile properties, estimation can be carried out on the scale of either the response or the link function. The advantage of using the latter becomes tangible when implementing fast optimizers for linear regression in the presence of large datasets. We show the theoretical properties of the estimator and derive an efficient method to obtain standard errors. The good performance and merit of our methods are illustrated by means of a simulation study and a real data analysis; where we investigate income inequality in the European Union (EU) using data from a sample of about two million households. We find a significant association between inequality, as measured by quantile ratios, and certain macroeconomic indicators; and we identify countries with outlying income inequality relative to the rest of the EU. An implementation of the proposed methods is freely available.
Effect of exercise-based rehabilitation on functional capacity and renal function in type 2 diabetes mellitus with nephropathy: a randomized controlled trial
Authors: Nataraj Megha , Maiya G. Arun , Nagaraju Shankar Prasad , Shastry B. A. , Shivashankara K. N. , Shetty Sahana , Mayya Shreemathi S. 
Published: March 2024

Abstract
Introduction
Diabetic nephropathy is a growing public health challenge with implications on health. Renal function decline impacts the functional ability and overall health and well-being of individuals with diabetic nephropathy due to development of several renal manifestations. The objective of the study was to determine the effect of an exercise-based rehabilitation program on functional capacity and renal function among individuals with type 2 diabetic nephropathy.

Methods
A total of 283 individuals were screened and 60 eligible participants aged 45–70 years with diabetic nephropathy were randomly allocated (n = 30 each) to the intervention group (IG) and control group (CG), respectively. The study outcome measures comprised of functional capacity (6-min walk test) and renal function assessed at baseline, 12th week and 24th week. Participants allocated to IG received 12 weeks of exercise based rehabilitation (comprising of supervised + home-based exercises) along with standard care and followed-up till 24th week.

Results
The repeated measures ANOVA with Greenhouse–Geisser correction indicated significant timepoint*group interaction effect for 6-min walk distance F (1.71, 90.59) = 619, p < 0.001, serum creatinine F (1.23, 65.14) = 174.8, p < 0.001, estimated glomerular filtration rate F(1.15, 60.88) = 105.2, p < 0.001, serum urea F(1.48, 78.45) = 261.4, p < 0.001 and urine protein F (1.13, 59.82) = 4.58, p < 0.328.

Conclusion
The study found that exercise based rehabilitation improved both functional capacity and renal function among individuals with type 2 diabetic nephropathy.
Rhododendron poisoning in alpacas (Vicugna pacos) in Northern Germany
Authors: Schregel Johannes , Zdora Isabel , Gerhauser Ingo , Punsmann Teresa Maria , Aboling Sabine , Ganter Martin , Wagener Matthias Gerhard 
Published: March 2024

AbstractPoisoning is often suspected to be the origin of disease in South American camelids (SACs) by owners, but only in a few cases this assumption can be confirmed. In small ruminants, rhododendron poisoning is a common emergency for livestock veterinarians. However, this condition has rarely been reported in SACs so far. This paper provides information regarding clinical findings, hematology, clinical chemistry, and treatment of four alpacas after presumed intake of rhododendron leaves including pathological findings of one of the animals. Rhododendron leaves contain grayanatoxins that lead to hyperpolarization of excitable cells. Clinical signs that were observed in the presented alpacas comprised: salivation, dehydration, decreased motility of compartment 1, uncoordinated regurgitation, and cardiac arrhythmia. Clinical chemistry revealed that rhododendron poisoning was associated with metabolic acidosis and azotaemia, hyponatremia and hyperkalemia. Most striking macroscopic and histopathological findings included gastric ulceration, and renal infarcts along with inflammatory changes. Leaves of Rhododendron spp. were identified in the forestomach content of this animal. Affected animals were treated symptomatically as there is no specific antidote in rhododendron poisoning. This included parenteral rehydration, treatment of metabolic acidosis (infusion of sodium bicarbonate solution), and oral administration of activated charcoal to bind potential toxins. In addition, antibiotic treatment might be necessary to prevent aspiration pneumonia in case of uncoordinated regurgitation. Of the four animals, the worst affected alpaca was euthanized, one had minimal signs and two responded to supportive care and recovered. In conclusion, rhododendron poisoning might be fatal for alpacas in individual cases and therefore rhododendron bushes should not be placed in the habitat of SACs.
Volunteering Legacies from the Olympic Games: Missed Opportunities
Authors: Holmes Kirsten , Smith Karen A. , Lockstone-Binney Leonie , Shipway Richard , Ong Faith 
Published: March 2024

AbstractThis paper examines how far a post-event volunteering legacy is facilitated by event organising committees leveraging existing volunteering infrastructure in host communities. The paper uses the lens of regulatory capitalism to examine how the organising committees of the Sydney 2000 and London 2012 Olympic Games engaged with the third sector, and specifically the volunteering infrastructure of the host nations, in the planning, delivery and post-event phases to create a volunteering legacy for the host community. The two case studies involved 27 in-depth interviews with key stakeholders representing the organising committees and the volunteering infrastructure in the host cities. While the Sydney Olympics had no specific remit for legacy planning, the third sector led legacy efforts in Australia. At the London Olympics, there was a failure to engage with the third sector, which limited government-led legacy planning and implementation. In the latter case, the framework of regulatory capitalism prioritised contracts with the private sector over meaningful engagement with the third sector.
In-vitro selection of lactic acid bacteria to combat Salmonella enterica and Campylobacter jejuni in broiler chickens
Authors: Wishna-Kadawarage Ramesha N. , Hickey Rita M. , Siwek Maria 
Published: March 2024

AbstractCampylobacter and Salmonella are the two most prominent foodborne zoonotic pathogens reported in the European Union. As poultry is one of the major sources of these pathogens, it is imperative to mitigate the colonization of these pathogens in poultry. Many strains of lactic acid bacteria (LAB) have demonstrated anti-Salmonella and anti-Campylobacter characteristics to varying degrees and spectrums which are attributed to the production of various metabolites. However, the production of these compounds and consequent antimicrobial properties are highly strain dependent. Therefore, the current study was performed to select a potent LAB and determine its causal attribute in inhibiting Salmonella enterica and Campylobacter jejuni, in-vitro. Six LAB (Lactiplantibacillus plantarum (LP), Lacticaseibacillus casei (LC), Limosilactobacillus reuteri (LR), Lacticaseibacillus rhamnosus (LRh), Leuconostoc mesenteroides (LM) and Pediococcus pentosaceus (PP)) and three serovars of Salmonella enterica (Typhimurium, Enterica and Braenderup) and Campylobacter jejuni were used in the current study. Spot overlays, well diffusion, co-culture and co-aggregation assays against Salmonella and well diffusion assays against Campylobacter jejuni were performed. Organic acid profiling of culture supernatants was performed using HPLC. The results indicated that LRh, LM and PP had the most significant anti-Salmonella effects while LP, LC, LM and PP displayed the most significant anti-Campylobacter effects. Lactic acid and formic acid detected in the culture supernatants seem the most likely source of the anti-Salmonella and anti-Campylobacter effects exhibited by these LAB. In conclusion, Leuconostoc mesenteroides displayed the most significant overall anti-pathogenic effects when compared to the other LAB strains studied, indicating its potential application in-vivo.
Is ‘hybrid work’ the new high-flying policy? insights from the aviation industry
Authors: Shao Sandra , Martensen Malte , Martensen Hannah , Reindl Cornelia 
Published: March 2024

AbstractThe return to working at the office after two years of remote work due to the COVID-19 pandemic entails challenges for employees and organizations alike. Organizations strive to create a pull towards working at the office—first and foremost to strengthen organizational culture, cohesiveness, and related outcomes. Employees do not want to give up on working from home (WFH) to maintain the newly gained autonomy and flexibility. The answer to unite organizational and individual needs seems to be a hybrid work policy, i.e., a fixed weekly or monthly ratio of working at the office and WFH. However, we know little about two things so far: the effects of a hybrid work model and how it should be designed to achieve its goals. This study takes a qualitative approach to investigate individual and organizational outcomes of a 50/50 hybrid work policy in an aviation industry IT company. Results indicate that while employees generally appreciate the policy, individual WFH desires also depend on the task structure of employees. The fixed 50% ratio also raised resistance among employees not being considered flexible enough to meet the needs of individual teams and team members. Primary recommendations for the design of hybrid work policies are given that underline the persisting importance of employee autonomy and flexibility concerns and the rising role of creating the office as a ‘social hub’.
A Novel Peptide Driving Neurodegeneration Appears Exclusively Linked to the α7 Nicotinic Acetylcholine Receptor
Authors: Ranglani Sanskar , Hasan Sibah , Komorowska Joanna , Medina Nathalia Mayag , Mahfooz Kashif , Ashton Anna , Garcia-Ratés Sara , Greenfield Susan 
Published: March 2024

AbstractT14, a 14mer peptide, is significantly increased in the pre-symptomatic Alzheimer’s disease brain, and growing evidence implies its pivotal role in neurodegeneration. Here, we explore the subsequent intracellular events following binding of T14 to its target α7 nicotinic acetylcholine receptor (nAChR). Specifically, we test how various experimental manipulations of PC12 cells impact T14-induced functional outcomes. Three preparations were compared: (i) undifferentiated vs. NGF-differentiated cells; (ii) cells transfected with an overexpression of the target α7 nAChR vs. wild type cells; (iii) cells transfected with a mutant α7 nAChR containing a mutation in the G protein-binding cluster, vs. cells transfected with an overexpression of the target α7 nAChR, in three functional assays – calcium influx, cell viability, and acetylcholinesterase release. NGF-differentiated PC12 cells were less sensitive than undifferentiated cells to the concentration-dependent T14 treatment, in all the functional assays performed. The overexpression of α7 nAChR in PC12 cells promoted enhanced calcium influx when compared with the wild type PC12 cells. The α7345–348 A mutation effectively abolished the T14-triggered responses across all the readouts observed. The close relationship between T14 and the α7 nAChR was further evidenced in the more physiological preparation of ex vivo rat brain, where T30 increased α7 nAChR mRNA, and finally in human brain post-mortem, where levels of T14 and α7 nAChR exhibited a strong correlation, reflecting the progression of neurodegeneration. Taken together these data would make it hard to account for T14 binding to any other receptor, and thus interception at this binding site would make a very attractive and remarkably specific therapeutic strategy.