bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase 1 study combining elotuzumab with autologous stem cell transplant and lenalidomide for multiple myeloma
Authors: Coffey David G , Osman Keren , Aleman Adolfo , Bekri Selma , Kats Simone , Dhadwal Amishi , Catamero Donna , Kim-Schulze Seunghee , Gnjatic Sacha , Chari Ajai , Parekh Samir , Jagannath Sundar , Cho Hearn Jay 
Published: April 2024

BackgroundAutologous stem cell transplantation (ASCT) after induction therapy improves disease-free survival for patients with multiple myeloma (MM). While the goal of ASCT is to render a minimal disease state, it is also associated with eradication of immunosuppressive cells, and we hypothesize that early introduction of immunotherapy post-ASCT may provide a window of opportunity to boost treatment efficacy.MethodsWe conducted a phase 1 clinical trial to investigate the application of autologous lymphocyte infusion and anti-SLAMF7 monoclonal antibody, elotuzumab, after ASCT in patients with newly diagnosed MM previously treated with induction therapy. In addition to CD34+ stem cells, peripheral blood mononuclear cells were harvested prior to transplant and infused on day 3 after stem cell infusion to accelerate immune reconstitution and provide autologous natural killer (NK) cells that are essential to the mechanism of elotuzumab. Elotuzumab was administered starting on day 4 and then every 28 days after until 1 year post-ASCT. Cycles 4–12 were administered with standard-of-care lenalidomide maintenance.ResultsAll subjects were evaluated for safety, and 13 of 15 subjects completed the treatment protocol. At 1 year post-ASCT, the disease status of enrolled subjects was as follows: five stringent complete responses, one complete response, six very good partial responses, one partial response, and two progressive diseases. The treatment plan was well tolerated, with most grade 3 and 4 AEs being expected hematologic toxicities associated with ASCT. Correlative analysis of the immune microenvironment demonstrated a trend toward reduced regulatory T cells during the first 3 months post-transplant followed by an increase in NK cells and monocytes in patients achieving a complete remission.ConclusionsThis phase 1 clinical trial demonstrates that early introduction of immunotherapy after ASCT is well tolerated and shows promising disease control in patients with MM, accompanied by favorable changes in the immune microenvironment.Trial registration numberNCT02655458.
Analysis of the hidden-charm pentaquark states based on magnetic moment and transition magnetic moment
Authors: Guo Fei , Li Hao-Song 
Published: April 2024

AbstractIn this work, we calculate the magnetic moments of the $$P^{N^{0}}_{\psi }$$

P
ψ

N
0

states and $$P^{\Delta ^{0}}_{\psi }$$

P
ψ

Δ
0

states with valence quark content $${\bar{c}}cudd $$

c

¯

c
u
d
d

in molecular model, diquark–diquark–antiquark model and diquark–triquark model, as well as the transition magnetic moments in the molecular model. At the same time, we also calculate magnetic moments and transition magnetic moments of $$P^{\Delta ^{++}}_{\psi }$$

P
ψ

Δ

+
+

states and $$P^{\Delta ^{-}}_{\psi }$$

P
ψ

Δ
-

states in the molecular model as additional products. Our results show that in the diquark–diquark–antiquark model, the magnetic moments of $$ \lambda $$
λ
excitation state are usually larger than the magnetic moments of $$ \rho $$
ρ
excitation state. We find some interesting proportional relationships between the expressions of transition magnetic moments. The results provide important insights for future experimental observation of hidden-charm pentaquark states and help to distinguish their inner structures. With these efforts, our understanding of the properties for the hidden-charm pentaquark states will become more abundant.
Dossiê: “Turismo em tempos de Pandemia”
Authors: Cruz Rita de Cássia Ariza da , Todesco Carolina 
Published: April 2024

O presente dossiê resulta do trabalho ininterrupto, realizado nos últimos dois anos e meio, pela Rede Internacional de Pesquisa “Turismo em tempos de pandemia: uma análise multi e transescalar”, cuja coordenação geral está abrigada no Laboratório de Estudos Regionais-LERGEO, do Departamento de Geografia da Faculdade de Filosofia, Letras e Ciências Humanas-FFLCH da Universidade de São Paulo, e a qual reúne, na atualidade, pesquisadores de 32 Instituições de Ensino e Pesquisa de Brasil, Argentina, Moçambique e Portugal. Além disso, esse dossiê se soma a outros 4 publicados em periódicos de ampla circulação no Brasil (Caderno Virtual de Turismo, Revista GEOUERJ, Revista Formação) e no exterior, como é o caso da Revista Confins Franco-Brasileira. Outros dois livros, um livro de ensaios, publicado no início de 2021 pela Editora da FFLCH/USP, e um livro com resultados de pesquisa alcançados ao longo desse período (o qual se encontra em preparação), denotam a grande capacidade de trabalho dos pesquisadores da Rede assim como seu compromisso com a produção de um conhecimento crítico sobre efeitos deletérios da crise pandêmica sobre o setor de turismo, sobre as respostas dadas pela sociedade, pelo Estado e pelos agentes de mercado diante do imponderável e sobre perspectivas para o futuro da atividade nos países estudados.
O mapeamento colaborativo e a mobilização de Conhecimentos Geográficos Poderosos na escola
Authors: GANZ TAYLENE MARCELE , Stefenon Daniel Luiz 
Published: April 2024

Esse artigo apresenta reflexões de um estudo de caso que contou com a participação de 225 estudantes de Ensino Médio de uma escola pública do interior do Paraná, com os quais foram desenvolvidas sequências didáticas com a plataforma Google My Maps. Através delas analisamos as potencialidades didáticas do mapeamento colaborativo no que diz respeito à mobilização de conhecimento geográfico poderoso na escola, por meio do balizamento teórico-metodológico oferecido na tipologia de Alaric Maude. Nessa perspectiva, o conhecimento geográfico é visto como um conjunto de referências capazes aprofundar as formas pelas quais os estudantes veem o mundo e a si mesmos e de oferecer condições para a promoção de uma maior consciência para a ação social. Concluiu-se que as técnicas de mapeamento colaborativo mobilizadas e estudadas ao longo da investigação contribuíram para a construção das diferentes dimensões do conhecimento geográfico poderoso, evidenciando o seu potencial para a promoção de diferentes saberes ligados ao pensamento geográfico na educação básica.
Evidence for Infant-directed Speech Preference Is Consistent Across
Large-scale, Multi-site Replication and Meta-analysis
Authors: Zettersten Martin , Cox Christopher , Bergmann Christina , Tsui Angeline Sin Mei , Soderstrom Melanie , Mayor Julien , Lundwall Rebecca A. , Lewis Molly , Kosie Jessica E. , Kartushina Natalia , Fusaroli Riccardo , Frank Michael C. , Byers-Heinlein Krista , Black Alexis K. , Mathur Maya B. 
Published: April 2024

Abstract
There is substantial evidence that infants prefer infant-directed speech (IDS) to adult-directed speech (ADS). The strongest evidence for this claim has come from two large-scale investigations: i) a community-augmented meta-analysis of published behavioral studies and ii) a large-scale multi-lab replication study. In this paper, we aim to improve our understanding of the IDS preference and its boundary conditions by combining and comparing these two data sources across key population and design characteristics of the underlying studies. Our analyses reveal that both the meta-analysis and multi-lab replication show moderate effect sizes (d ≈ 0.35 for each estimate) and that both of these effects persist when relevant study-level moderators are added to the models (i.e., experimental methods, infant ages, and native languages). However, while the overall effect size estimates were similar, the two sources diverged in the effects of key moderators: both infant age and experimental method predicted IDS preference in the multi-lab replication study, but showed no effect in the meta-analysis. These results demonstrate that the IDS preference generalizes across a variety of experimental conditions and sampling characteristics, while simultaneously identifying key differences in the empirical picture offered by each source individually and pinpointing areas where substantial uncertainty remains about the influence of theoretically central moderators on IDS preference. Overall, our results show how meta-analyses and multi-lab replications can be used in tandem to understand the robustness and generalizability of developmental phenomena.
EHDS and Free Movement of Patients: What EU Intervention is Needed?
Authors: van de Gronden Johan , Veenbrink Marc 
Published: April 2024

Abstract
The European Commission issued a proposal for a Regulation on the European Health and Data Space to improve patient mobility. This EHDS Regulation lays down rules for the exchange of digital health data for primary use (treatment) and for secondary use (i.e. research, policymaking). This proposal has far-reaching implications for national healthcare systems. The question arises whether, with this draft, the Commission in fact proposes to overstep the powers of the European Union, as the delivery and organization of healthcare belongs to the competences of the Member States. Furthermore, the (lack of) exchange of digital health data is not the only hinderance for the free movement of patients. The current set-up of the Patient Directive and the Social Security Coordination Regulation also discourages patients from seeking treatment abroad. Therefore, a more integrated approach in the form of a new Patient Regulation is, in our view, needed.
Historical Consciousness and the Uses of the Past: The Nineteenth-Century Parthenon Replicas
Authors: Tuori Kaius 
Published: April 2024

Abstract
The idea of making a replica of an ancient building such as the Parthenon involves a complex set of emotions, historical thought processes and usages of memory. This article explores the historical process and the politics of memory involved in building replicas of the Parthenon through a set of nineteenth-century examples that illustrate crucial changes in the approaches to history. These processes are juxtaposed and compared with the restoration works on the original Parthenon itself. In doing so, it maintains that the aspects of historical consciousness that the reconstructions both relied upon and sought to manipulate should be seen through the lens of the uses of the past. Arguing against a simplistic notion of the replicas of Parthenon being simply manifestations of the nationalism and classicism of the day, it maintains that they should be seen as works of historical self-definition and the generation of meanings through historical identification.
Canteen waste as food for black soldier fly larvae: risk of heavy metals accumulation? Variability during one year of rearing
Authors: Grosso F. , Calà E. , Regalli N. , Meneguz M. 
Published: April 2024

Abstract
Worldwide, about 244 million t/yr of waste are produced by canteens and restaurant, of which 4.7 million t/yr are generated at the Italian level. Canteen waste (CW) could be used for feeding larvae of insect to obtain new marketable products (e.g. protein meal, frass and chitin). Black Soldier Fly Larvae (BSFL) are voracious and polyphagous species, and CW is a complete food for them. Furthermore, BSFL are capable to bioaccumulate some heavy metals thus allowing to obtain safe organic frass, but the bioaccumulation in larvae intended for feed purpose needs to be evaluated. The CW was sampled once a month and the sampling was carried out for a year from a local canteen, located in the northern part of Italy. The feeding was conducted in quadruplicate in plastic containers (12 l) and 2,000 g of CW and 2,000 5 days-old larvae were allocated in each box. Each trial ended after 7 days and growth performances were evaluated. The results reported an average dry matter final larval biomass, along the year, of 83.8 ± 46.05 g and an average dry matter frass quantity equal to 199.9 ± 140.32 g. The percentage of dry matter for initial diet was 21.7 ± 14.10, for final larval biomass was 34.3 ± 7.39%, and for the residue of 62.2 ± 17.01%. The initial diet, BSFL before and after feeding, and the residue were sampled and oven dried. Elemental analyses were performed with a mass spectrometer in triplicate for evaluating arsenic, lead, cadmium, and mercury quantities within CW, residues and BSFL before and after feeding. This trial certifies the ability of BSFL to accumulate (BAF > 1) arsenic (average of 0.165 ± 0.1480 ppm), lead (average of 0.238 ± 0.1562 ppm), cadmium (average of 0.077 ± 0.0367 ppm), and mercury (average of 0.008 ± 0.0043 ppm) during feeding, and it proves that the bioaccumulation complies with European legal limits on the amount of heavy metals in larvae.
Analyzing the Impact of Concomitant COVID-19 Infection on Outcomes in Trauma Patients
Authors: Rafaqat Wardah , Abiad May , Lagazzi Emanuele , Argandykov Dias , Proaño-Zamudio Jefferson A. , Velmahos George C. , Hwabejire John O. , Parks Jonathan J. , Luckhurst Casey M. , DeWane Michael P. 
Published: April 2024

Background The impact of COVID-19 infection at the time of traumatic injury remains understudied. Previous studies demonstrate that the rate of COVID-19 vaccination among trauma patients remains lower than in the general population. This study aims to understand the impact of concomitant COVID-19 infection on outcomes in trauma patients. Methods We conducted a retrospective cohort study of patients ≥18 years old admitted to a level I trauma center from March 2020 to December 2022. Patients tested for COVID-19 infection using a rapid antigen/PCR test were included. We matched patients using 2:1 propensity accounting for age, gender, race, comorbidities, vaccination status, injury severity score (ISS), type and mechanism of injury, and GCS at arrival. The primary outcome was inpatient mortality. Secondary outcomes included hospital length of stay (LOS), Intensive Care Unit (ICU) LOS, 30-day readmission, and major complications. Results Of the 4448 patients included, 168 (3.8%) were positive (COV+). Compared with COVID-19-negative (COV-) patients, COV+ patients were similar in age, sex, BMI, ISS, type of injury, and regional AIS. The proportion of White and non-Hispanic patients was higher in COV- patients. Following matching, 154 COV+ and 308 COV- patients were identified. COVID-19-positive patients had a higher rate of mortality (7.8% vs 2.6%; P = .010), major complications (15.6% vs 8.4%; P = .020), and thrombotic complications (3.9% vs .6%; P = .012). Patients also had a longer hospital LOS (median, 9 vs 5 days; P < .001) and ICU LOS (median, 5 vs 3 days; P = .025). Conclusions Trauma patients with concomitant COVID-19 infection have higher mortality and morbidity in the matched population. Focused interventions aimed at recognizing this high-risk group and preventing COVID-19 infection within it should be undertaken.
Clinical Implications of Over- and Under-Triage Using Need for Trauma Intervention and Cribari Indices
Authors: Lenart Emily K. , Byerly Saskya E. , Gross Megan G. , Ali Yasmin M. , Evans Cory R. , Easterday Thomas S. , Howley Isaac W. , Kerwin Andy J. , Fischer Peter E. , Filiberto Dina M. 
Published: April 2024

Background Need for Trauma Intervention (NFTI) score was proposed to help identify injured trauma patients while minimizing under (UT) and over triage (OT). Using a national database, we aimed to describe UT and OT of NFTI vs standard Cribari method (CM) and hypothesized triage sensitivity remains poor. Methods The 2021 Trauma Quality Improvement Program (TQIP) database was queried. Demographics, mechanism, verification level, interfacility transfer (IF), and level of activation were collected. Patients were stratified by both NFTI [+ vs -] and CM [Injury severity score (ISS) < 15 vs > 15]. UT was defined as NFTI + or ISS >15 without full trauma activation. Results 1,030,526 patients were identified in TQIP. 84,969 were UT and 97,262 were OT using NFTI while 94,020 were UT and 108,823 were OT using CM. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of NFTI is 49%, 89%, 45%, and 90%, respectively vs 43%, 87%, 39%, and 89% of CM, respectively. Age was higher in the UT group using both scores (52 vs 42, P < .0001 and 54 vs 42, P < .0001, respectively). Using MLR, level 2 and 3 verification, blunt mechanism, female, IF, and older age were associated with UT in both NFTI and CM. Level 1 verification, penetrating mechanism, male, no IF, and younger age were associated with OT. Conclusions Current prehospital triage criteria have poor sensitivity for identifying severely injured trauma patients by both NFTI and CM. UT increases as age of the patient increases. Further studies are needed to improve triage.
Acute Knee Crutch Use Provokes Changes to Postural Strategy
Authors: Maron Christian , Jendre Aron , Goble Daniel , Marks Charles , Haworth Joshua 
Published: April 2024

Single-leg knee crutches are a relatively new, hands-free mobility assistive device with benefits over standard axillary crutches. Our main goal in this study was to evaluate balance ability in a healthy population upon first exposure to the knee crutch device. We had 20 healthy individuals ( M age = 21.1; SD = 1.5 years ) complete baseline static and dynamic balance tests on a force plate, followed by knee crutch fitting, a self-selected duration of ambulation practice, and another round of balance testing while wearing the knee crutch. We used the BTrackS Balance Test (BBT) to measure static balance, and the BTrackS Limits of Stability (BLOS) test to measure dynamic balance, and we created a custom lateral bias score from the BLOS results. On average, participants self-selected 3.1 minutes of ambulation practice. Wearing the knee crutch caused a near doubling of static balance path length and a large reduction in percentile ranking on the BBT. Dynamic balance area was more than halved ( p < .001), with lateral bias scores during the BLOS, indicating that participants heavily favored their non-crutched leg ( p < .001). Our results indicate that static and dynamic balance were significantly altered when wearing the knee crutch, and participants seemed to switch to a single leg stance strategy. Despite these balance changes, participants were quickly ready and willing to complete independent ambulation and balance testing procedures using the single-leg knee crutch.
The effectiveness and safety of centralized early rehabilitation care for critically ill children with severe acquired brain injury: A retrospective cohort and implementation study
Authors: Zhang Ting , Duan Xiao-ling , Chen Yu-xia , Feng Ying , Huang Qin-rong , Tang Xiang , Lin Li , Xiao Nong 
Published: April 2024

Background Most children with neurocritical illness are at risk of physical, neurocognitive, and psychosocial sequelae and need centralized early rehabilitation care. Objective To identify the effectiveness and safety of centralized early rehabilitation care for children with severe acquired brain injury. Methods This is a mixed methods study—an implementation study and single-center retrospective cohort study with historical control. All children with severe acquired brain injury hospitalized in a specialized rehabilitation center in a comprehensive tertiary pediatric hospital between September 2016 and August 2020 were included. Patients treated in the centralized early rehabilitation unit were compared to historical controls dispersed in the normal inpatient rehabilitation ward. The effectiveness outcomes were measured by the Pediatric Cerebral Performance Category (PCPC) scale and the incidence of newly onset comorbidities. The safety outcomes were indicated by the mortality rate and the incidence of unexpected referrals. Results One hundred seventy-five patients were included. The delta PCPC scores of the first 4 weeks of inpatient rehabilitation in the intervention group were significantly lower than the control group ( Z = −2.395, p = 0.017). The PCPC scores at 1 year in the intervention group were significantly reduced as compared to the control group ( Z = −3.337, p = 0.001). The incidence of newly onset pneumonia/bronchitis was also decreased in the intervention group ( χ2 = 4.517, p = 0.034). No death of patients was recorded, and there was no significant difference in unexpected referral rate between the two groups ( χ2 = 0.374, p = 0.541). Conclusions The centralized pediatrics early rehabilitation unit is effective and safe for children with severe acquired brain injury. Further multicenter prospective implementation studies on effectiveness, safety, and economic evaluation are needed.
A Political Ecology of Resistance: Actions and Reactions of Agrarian Socio-territorial Movements in Latin America
Authors: Moura Joana Tereza Vaz de , Cavalcante Leandro Vieira , Jara Cristian Emanuel , Saettone Julieta , Fernandes Bernardo Mancano , Villalba Ana Eliza , Bitencourt Silmara Olveira Moreira , Bolañez Claurdia Yesica Fonzo 
Published: April 2024

Territorial disputes have intensified in Latin America due to the advance of neo-extractivism, while agrarian socio-territorial movements have created strategies of resistance and reinvention of their territorialities. In dialogue with political ecology perspectives, we seek to understand the dynamics of these movements in Argentina and Brazil. We analyzed the information systematized in the DataLuta Network database on the actions and reactions of socio-territorial movements based on published news reports in 2021. We noted that, even with different political contexts, the socio-territorial movements of Argentina and Brazil have included environmental issues in their agendas, demonstrated by their commitment to the fight against pesticides, agro-industry, and mining, and in defense of agroecology and the production of healthy food. La disputa territorial se ha intensificado en América Latina por el avance del neoextractivismo, mientras que los movimientos socioterritoriales agrarios han creado estrategias de resistencia y reinvención de sus territorialidades. Dialogando con las perspectivas de la ecología política, buscamos comprender la dinámica de estos movimientos en Argentina y Brasil. Analizamos la información sistematizada en la base de datos de la Red DataLuta sobre las acciones y reacciones de los movimientos socioterritoriales a partir de las noticias publicadas en 2021. Notamos que, aún con diferentes contextos políticos, los movimientos socioterritoriales de Argentina y Brasil han incluido la cuestión ambiental en sus agendas, que se manifiesta en su compromiso con la lucha contra los plaguicidas, la agroindustria y la minería, en la defensa de la agroecología y la producción de alimentos saludables.