bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of core stability and feedback music on upper body mediolateral movements during cycling
Authors: Jeong Siwoo , Kim Si-hyun , Park Kyue-nam 
Published: March 2024

Abstract
Background
Asymmetry in involuntary trunk motion during voluntary movements of the lower extremities is a risk factor for musculoskeletal injuries and may be related to core stability. Core stability plays a pivotal role in maintaining postural stability during distal segment movements. Because mediolateral head motion partially represents trunk motion during rhythmic movements, controlling it can help ensure symmetric trunk motion. This study aimed to investigate the relationship between core stability and asymmetric trunk motion during rhythmic movements, and to evaluate the effects of feedback music on mediolateral head motion.

Methods
We developed a system that uses a wireless earbud and a high-resolution inertial measurement unit sensor to measure head angle and provide feedback music. When the head angle exceeds a predefined threshold, the music is muted in the earbud on the side of the head tilt. In our lab-based study, we measured head angles during cycling at 70% of maximum speed using this self-developed system, and compared them between individuals with good (Sahrmann core stability test: 2–5 level) and poor core stability (0–1 level). The amplitude of mediolateral head motion was represented by the difference between the left and right peak angles, and the symmetry in mediolateral head motion was represented by the average of left and right peak angles.

Results
Individuals with poor core stability demonstrated significantly greater amplitude of, and less symmetry in, mediolateral head motion than those with good core stability. Additionally, feedback music significantly reduced the amplitude of mediolateral head motion in both the good- and poor-core-stability groups.

Conclusion
Our findings indicate that core stability is crucial for maintaining symmetric head motion during rhythmic movements like cycling. Feedback music could serve as an effective tool for promoting symmetry in head motion and thus preventing musculoskeletal injuries.
Determinants of market outlet choices by smallholder mango farmers in Aleta Chuko District, Sidama Region, Ethiopia: a multivariate probit approach
Authors: Legesse Tibebu , Ashebir Aneteneh , Ganewo Zerhun , Alemu Abera , Samuel Andachew 
Published: March 2024

AbstractSelecting appropriate market outlets offer the opportunity for farmers to capture a bigger share of the price paid by final consumers. However, smallholder farmers in developing countries are still confronted with myriad challenges regarding selecting profitable market outlets. Thus, the main objective of this study was to analyze determinants of market outlet choices by smallholder mango farmers in Aleta Chuko District, Sidama Region, Ethiopia. The study's representative 391 sample mango producers were selected using a multi-stage sample selection technique and a cross-sectional research approach. Descriptive statistics and the multivariate probit model were used to analyze the data. The result of the study showed that the probability of mango producers to choose consumer, collector, and retailer and wholesaler market outlets was 38%, 39.4%, 41% and 25%, respectively. This shows that retailer was the most likely chosen market outlet while wholesaler was the less likely chosen market outlet. The joint probability of farmers to choose the four market outlets is (0.042%) lower than the likely of not choosing four market outlets (23.21%). The result of the multivariate probit model showed that the sex of the household head, age of the household head, educational level of the household head, the quantity of mangoes produced, size of the land allocated for mango production, use of market information, credit access, livestock holdings, and distance to the nearest market were all statistically and significantly influencing factors in the market outlet choice behavior of mango producers. Based on the results of this study, the government and other concerned organizations should take action to improve the efficient marketing of mango producers in all outlets by providing market information, expanding and following up on extension services, increasing credit access, and building roads and other marketing infrastructure in the study area.
Cluster-specific associations between the gut microbiota and behavioral outcomes in preschool-aged children
Authors: van de Wouw Marcel , Wang Yanan , Workentine Matthew L. , Vaghef-Mehrabani Elnaz , Barth Delaney , Mercer Emily M. , Dewey Deborah , Arrieta Marie-Claire , Reimer Raylene A. , Tomfohr-Madsen Lianne , Giesbrecht Gerald F. 
Published: March 2024

Abstract
Background
The gut microbiota is recognized as a regulator of brain development and behavioral outcomes during childhood. Nonetheless, associations between the gut microbiota and behavior are often inconsistent among studies in humans, perhaps because many host-microbe relationships vary widely between individuals. This study aims to stratify children based on their gut microbiota composition (i.e., clusters) and to identify novel gut microbiome cluster-specific associations between the stool metabolomic pathways and child behavioral outcomes.

Methods
Stool samples were collected from a community sample of 248 typically developing children (3–5 years). The gut microbiota was analyzed using 16S sequencing while LC-MS/MS was used for untargeted metabolomics. Parent-reported behavioral outcomes (i.e., Adaptive Skills, Internalizing, Externalizing, Behavioral Symptoms, Developmental Social Disorders) were assessed using the Behavior Assessment System for Children (BASC-2). Children were grouped based on their gut microbiota composition using the Dirichlet multinomial method, after which differences in the metabolome and behavioral outcomes were investigated.

Results
Four different gut microbiota clusters were identified, where the cluster enriched in both Bacteroides and Bifidobacterium (Ba2) had the most distinct stool metabolome. The cluster characterized by high Bifidobacterium abundance (Bif), as well as cluster Ba2, were associated with lower Adaptive Skill scores and its subcomponent Social Skills. Cluster Ba2 also had significantly lower stool histidine to urocanate turnover, which in turn was associated with lower Social Skill scores in a cluster-dependent manner. Finally, cluster Ba2 had increased levels of compounds involved in Galactose metabolism (i.e., stachyose, raffinose, alpha-D-glucose), where alpha-D-glucose was associated with the Adaptive Skill subcomponent Daily Living scores (i.e., ability to perform basic everyday tasks) in a cluster-dependent manner.

Conclusions
These data show novel associations between the gut microbiota, its metabolites, and behavioral outcomes in typically developing preschool-aged children. Our results support the concept that cluster-based groupings could be used to develop more personalized interventions to support child behavioral outcomes.
Creating the Chinese version of the transgender attitudes and beliefs scale
Authors: Wang Zhanqiang , Liu Yang , Dong Hanwen , Zhang Yueqian , Yang Kebing , Yang Qingyan , Di Xiaolan , Niu Yajuan 
Published: March 2024

Abstract
Background
Trans persons’ physical and mental health is easily affected by the attitude of those around them. However, China currently lacks a valid psychometric instrument to investigate people’s attitudes toward trans persons. Therefore, this study modifies the English version of the Transgender Attitudes and Beliefs Scale (TABS) to suit the Chinese context. It subsequently examines the reliability and validity of the Chinese version of the TABS.

Methods
This study recruited 1164 university students, aged 18–25 years, from 7 regions of China. SPSS26.0 and AMOS24.0 were used for data statistical analysis. Critical ratio method and correlation coefficient method were used for item analysis. Exploratory factor analysis and confirmatory factor analysis were used to test the structural validity of the Chinese version of Transgender Beliefs and Attitudes Scale, and the internal consistency reliability of the scale was tested.

Results
The TABS-C contains 26 items with 3 factors. The Cronbach’s alpha was 0.957 for the total scale and 0.945, 0.888, and 0.885 for the 3 factors. The half-point reliability of the scale was 0.936, and the retest reliability was 0.877. The Pearson correlation coefficients for the 3 factors and the total scale score ranged from 0.768 to 0.946.

Conclusion
The TABS-C has reliable psychometric properties and is suitable for usage among college students in the Chinese context.
Heritagutopia: a new utopian paradigm
Authors: Donner Luca , Sorcinelli Francesca 
Published: March 2024

AbstractThe progress of humanity has always, and sometimes even unconsciously, been confronted with the concept of utopia at the social, economic, political, and urban level. The strength of every utopian vision lies in the disruptive factor inherent in the idea of metamorphosis of the status quo. In the urban context, it represents the pillar on which the vision of modern society and its city are based and understood as potential and progress for mankind. Authors such as Bauman, Bloch, Calvino, More, Mumford, Tafuri, and others, have formed the theoretical framework of the dialectic on which this study is based. As we know, the history of architecture and urban planning provides multiple models of utopia that have alternated over time, such as the ones proposed in the 60 and 70 s by Archigram, Superstudio, Yona Friedman or the Japanese Metabolist movement, just to name a few. Starting from these experiences at the urban scale, and supported by contributions from disciplines such as philosophy, literature, and sociology, this research defines a new model of utopia called “Heritagutopia”. It is a new utopian paradigm, and not dystopian as it will be demonstrated, which is based on the symbiosis between urban historical heritage and abandoned industrial areas or run-down infrastructures. The first one, due to the centripetal economic dynamics, leaves its current location to find exile in the second one, through parasitic urban tactics. It is a migration, or an exile in some ways. However, in both cases this new condition allows the two contexts not to vanish and to regain possession of their lost identity, or rather to regenerate themselves, acquiring a new life. It allows to break into custom with a vision that undermines the state of affairs, subverts its factors, by proposing an alternative vision, sometimes dreamlike, but deliberately provocative as every utopia wants to be.
Evolution of cultural landscape heritage layers and value assessment in urban countryside historic districts: the case of Jiufeng Sheshan, Shanghai, China
Authors: Li Xufang , Zhou Xiangpin , Weng Feifan , Ding Fanzhuo , Wu Yijing , Yi Zhenxin 
Published: March 2024

Abstract
The heritage value of the historic urban countryside, as a remnant in the transition between the urban boundary and the natural environment, is a consequence of the spatial and temporal evolution of the city. However, through repeated social transformations, the conflicts between urban construction and cultural landscape heritage preservation have increased, resulting in the gradual disappearance of their cultural landscape heritage. This study takes the Sheshan Urban Countryside Historic District in Shanghai and interprets the layers of Sheshan's cultural landscape heritage into five periods, Emergence, Development and Exploration, Diversity and Prosperity, Turbulence and Change, and Stability and Precipitation. It analyzes the evolution of the layers of the cultural landscape heritage by applying Historic Urban Landscape Historic Land use Assessment (HUL) and interpreting the layers of the cultural heritage of Sheshan using Historical Landscape Assessment (HLA) to identify the characteristics and values of Sheshan's layers of heritage. The study indicates that the cultural landscape heritage of Jiufeng Sheshan exhibits four types of stratigraphic relationships: accretion, juxtaposition, overlay, and decline. This findings suggest a continuous evolutionary feature of superposition of multiple stratigraphic patterns. Moreover, the heritage value of the cultural landscape layers of Jiufeng Sheshan has shown a higher growth rate in the modern period. The integrity and survival status of modern religious and scientific buildings are more complete compared to the literati gardens and Buddhist relics. Based on the knowledge and value assessment of its cultural landscape heritage, it is necessary to intervene in the concept of living conservation and renewal of landscape heritage. This involves devising a conservation and renewal strategy for cultural landscape heritage that conforms to the law of historical stratification and connect the scattered historical and cultural relics. This study provides a reference for the conservation and inheritance of cultural landscape heritage in urban countryside historical areas and the organic renewal of urban and rural heritage.
Determinants of acute kidney injury during high-power mechanical ventilation: secondary analysis from experimental data
Authors: Gattarello Simone , Lombardo Fabio , Romitti Federica , D’Albo Rosanna , Velati Mara , Fratti Isabella , Pozzi Tommaso , Nicolardi Rosmery , Fioccola Antonio , Busana Mattia , Collino Francesca , Herrmann Peter , Camporota Luigi , Quintel Michael , Moerer Onnen , Saager Leif , Meissner Konrad , Gattinoni Luciano 
Published: March 2024

Abstract
Background
The individual components of mechanical ventilation may have distinct effects on kidney perfusion and on the risk of developing acute kidney injury; we aimed to explore ventilatory predictors of acute kidney failure and the hemodynamic changes consequent to experimental high-power mechanical ventilation.

Methods
Secondary analysis of two animal studies focused on the outcomes of different mechanical power settings, including 78 pigs mechanically ventilated with high mechanical power for 48 h. The animals were categorized in four groups in accordance with the RIFLE criteria for acute kidney injury (AKI), using the end-experimental creatinine: (1) NO AKI: no increase in creatinine; (2) RIFLE 1-Risk: increase of creatinine of > 50%; (3) RIFLE 2-Injury: two-fold increase of creatinine; (4) RIFLE 3-Failure: three-fold increase of creatinine;

Results
The main ventilatory parameter associated with AKI was the positive end-expiratory pressure (PEEP) component of mechanical power. At 30 min from the initiation of high mechanical power ventilation, the heart rate and the pulmonary artery pressure progressively increased from group NO AKI to group RIFLE 3. At 48 h, the hemodynamic variables associated with AKI were the heart rate, cardiac output, mean perfusion pressure (the difference between mean arterial and central venous pressures) and central venous pressure. Linear regression and receiving operator characteristic analyses showed that PEEP-induced changes in mean perfusion pressure (mainly due to an increase in CVP) had the strongest association with AKI.

Conclusions
In an experimental setting of ventilation with high mechanical power, higher PEEP had the strongest association with AKI. The most likely physiological determinant of AKI was an increase of pleural pressure and CVP with reduced mean perfusion pressure. These changes resulted from PEEP per se and from increase in fluid administration to compensate for hemodynamic impairment consequent to high PEEP;
An operative case of gastric cancer with ectopic bile duct drainage in the lesser curvature of the stomach
Authors: Hashimoto Kazuaki , Ihara Tsukasa , Maruyama Yuichiro , Tomisaki Shinichi , Harada Hiroshi 
Published: March 2024

Abstract
Background
Among the various anomalies of the biliary system, a double common bile duct with ectopic drainage in the stomach is rare. Furthermore, ectopic bile ducts are extremely rare in gastric cancers.

Case presentation
A 67-year-old man was admitted to our hospital with gastric cancer and ectopic left extrahepatic bile duct drainage in the stomach. Pre-operative testing revealed no communication between the intrahepatic bile ducts. Distal gastrectomy and bile duct jejunostomy were performed. The post-operative course was uneventful, and the patient did not exhibit recurrence for 39 mo.

Conclusions
Although it is uncertain whether sustained bile exposure from an ectopic bile duct is related to gastric cancer, short-term follow-up might be necessary because of the possibility of gastric cancer.
Adaptation and establishment of Habrobracon hebetor Say in the population of stored moths pests of date, Ephestia kuehniella Zeller and Plodia interpunctella Hübner
Authors: Latifian Masoud , Bahmani Negar 
Published: March 2024

Abstract
Background
Habrobracon hebetor (Hymenoptera: Braconidae) is a larval ectoparasitoid, mainly of pyralid moths of the stored pests of date, Plodia interpunctella Hübner and Ephestia kuehniella Zeller. It has some suitable characteristics for use in biological control of stored moth pests. The aim of this study was to compare the ability of H. hebetor establishment in the population of two important date storage moth pests P. interpunctella and E. kuehniella, and its role in their population fluctuations.

Results
The population growth trends of two host species increased in the first 6 weeks and in the 17th to 22nd weeks of the 6-month period of conducting tests. The peaks of larval population of the two species were in the 10th and 21st weeks under temperature of 25 ± 2 °C, RH of 60 ± 5% and a photoperiod of 12:12, D:L. The pattern of fluctuation in the parasitism percentage in the larval population of the two moth species host was inconsistent with each other. The parasitism percentage was higher on the larval population of E. kuehniella than larval population of P. interpunctella. In E. kuehniella, the host population change rates were − 0.1 in the 10th and 15th weeks, while the highest rates were 0.1 and 0.8 in the 12th and 3rd weeks. The lowest level of parasitoid balance in the larval population of E. kuehniella and P. interpunctella was recorded in the 11th and 15th weeks, and the highest levels were recorded in the 20th and 24th weeks, respectively. The maximum probability rate of parasitoid non-establishment in E. kuehniella larval population was zero during the entire period and for P. interpunctella until the 22nd week.

Conclusion
In fact, there was a strong correlation between establishment success and the severity of host and parasitoid populations. Only in the larval population of P. interpunctella, the maximum probability of failure of establishment was 11.5%, due to the occurrence of the maximum population of parasitized larvae and the minimum ratio of non-parasitic and parasitic larvae.
What do adults living with obesity want from a chatbot for physical activity? – a qualitative study
Authors: Larbi Dillys , Wynn Rolf , Trondsen Marianne Vibeke , Årsand Eirik , Zanaboni Paolo , Denecke Kerstin , Gabarron Elia 
Published: March 2024

Abstract
Background
Regular physical activity helps to reduce weight and improve the general well-being of individuals living with obesity. Chatbots have shown the potential to increase physical activity among their users. We aimed to explore the preferences of individuals living with obesity for the features and functionalities of a modern chatbot based on social media, Artificial intelligence (AI) and other recent and relevant technologies.

Methods
In this study, we used qualitative methods. Focusing on individuals’ preferences for a chatbot to increase physical activity, we conducted both individual interviews and focus groups with nine adult patients staying at Evjeklinikken, a Norwegian rehabilitation clinic for individuals living with morbid obesity. The interviews were fully transcribed and then analysed inductively using thematic analysis.

Results
Participants preferred motivational features such as social support, goal setting, physical activity illustrations, monitoring of physical activity behaviour and outcomes, and feedback, prompts and reminders. They also preferred features for connecting and synchronising with smartwatches and training device apps. Participants wanted a chatbot that is easy to use and allows for human assistance when needed. Regarding personalising the chatbot, the participants wanted to choose the language, number of messages, and turn functionalities on and off.

Conclusions
Co-designing chatbots with potential users is essential to understand their specific needs and preferences. We gained valuable insight into a diverse set of features and functionalities relevant to designing physical activity chatbots for individuals living with obesity. Behaviour change techniques are equally important as personalisation features and the option for synchronising with third-party devices. In future work, we will consider the collected needs in the development of a physical activity chatbot to ensure acceptance and adherence to the digital health intervention.
PACE: A Randomized Phase II Study of Fulvestrant, Palbociclib, and Avelumab After Progression on Cyclin-Dependent Kinase 4/6 Inhibitor and Aromatase Inhibitor for Hormone Receptor–Positive/Human Epidermal Growth Factor Receptor–Negative Metastatic Breast Cancer
Authors: Mayer Erica L. , Ren Yue , Wagle Nikhil , Mahtani Reshma , Ma Cynthia , DeMichele Angela , Cristofanilli Massimo , Meisel Jane , Miller Kathy D. , Abdou Yara , Riley Elizabeth C. , Qamar Rubina , Sharma Priyanka , Reid Sonya , Sinclair Natalie , Faggen Meredith , Block Caroline C. , Ko Naomi , Partridge Ann H. , Chen Wendy Y. , DeMeo Michelle , Attaya Victoria , Okpoebo Amanda , Alberti Jillian , Liu Yuan , Gauthier Eric , Burstein Harold J. , Regan Meredith M. , Tolaney Sara M. 
Published: March 2024

PURPOSE Cyclin-dependent kinase (CDK) 4/6 inhibitors (CDK4/6is) are an important component of treatment for hormone receptor–positive/human epidermal growth factor receptor 2–negative (HER2–) metastatic breast cancer (MBC), but it is not known if patients might derive benefit from continuation of CDK4/6i with endocrine therapy beyond initial tumor progression or if the addition of checkpoint inhibitor therapy has value in this setting. METHODS The randomized multicenter phase II PACE trial enrolled patients with hormone receptor–positive/HER2– MBC whose disease had progressed on previous CDK4/6i and aromatase inhibitor (AI) therapy. Patients were randomly assigned 1:2:1 to receive fulvestrant (F), fulvestrant plus palbociclib (F + P), or fulvestrant plus palbociclib and avelumab (F + P + A). The primary end point was investigator-assessed progression-free survival (PFS) in patients treated with F versus F + P. RESULTS Overall, 220 patients were randomly assigned between September 2017 and February 2022. The median age was 57 years (range, 25-83 years). Most patients were postmenopausal (80.9%), and 40% were originally diagnosed with de novo MBC. Palbociclib was the most common previous CDK4/6i (90.9%). The median PFS was 4.8 months on F and 4.6 months on F + P (hazard ratio [HR], 1.11 [90% CI, 0.79 to 1.55]; P = .62). The median PFS on F + P + A was 8.1 months (HR v F, 0.75 [90% CI, 0.50 to 1.12]; P = .23). The difference in PFS with F + P and F + P + A versus F was greater among patients with baseline ESR1 and PIK3CA alterations. CONCLUSION The addition of palbociclib to fulvestrant did not improve PFS versus fulvestrant alone among patients with hormone receptor–positive/HER2– MBC whose disease had progressed on a previous CDK4/6i plus AI. The increased PFS seen with the addition of avelumab warrants further investigation in this patient population.