bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mediastinal and thoracic complications of necrotizing fasciitis of the head and neck
Authors: Lalwani Anil K. , Kaplan Michael J. 
Published: February 2007

AbstractMediastinal and thoracic extension of head and neck infections are rare but occur even in the modern antibiotic era. Early intervention is paramount to successful clinical outcome. 111Indium‐labeled white blood cell (WBC) scan, a new imaging modality, appears to play a role in complementing computed tomographic (CT) findings, demonstrating early extension of disease, and following therapeutic efficacy. Together, the CT scan and WBC scan aid in directing early intervention and extent of surgery in this disease of high‐potential mortality. We report 3 cases of deep head and neck infection complicated by mediastinal extension, including mediastinitis, pericardial effusion, and tampon‐ade, empyema, and respiratory failure. Early surgical intervention included neck drainage, tracheostomy, thoracotomy, and pericardiotomy. While usually associated with greater than 50% mortality, all of the patients in this series survived. Based on our experience, we recommend prompt aggressive surgical debride‐ment in treating mediastinal complications resulting from head and neck infections.
Head and Neck Sarcoma: Report of the Head and Neck Sarcoma Registry
Authors: Wanebo Harold J. , Koness R. James , Macfarlane John K. , Eilber Frederick R. , Byers Robert M. , Elias E. George , Spiro Ronald H. 
Published: February 2007

AbstractA Head and Neck Sarcoma Registry was established by the Society of Head and Neck Surgeons to review treatment results of a rare tumor by surgeons with special interest in this anatomic site. Two hundred fourteen patients were analyzed. There were 194 adult tumors and 20 pediatric tumors. The major sites included parotid and neck, 20%; face and forehead, 18%; maxilla and palate, 13%; scalp, 12%; mandible, 11%; paranasal sinuses, 7%; larynx, 2%; and oral cavity, 5%. Eighty‐four percent were resectable. The disease‐free survival was 56%; overall survival was 70% at 5 years. Major determinants of survival were adequacy of resection (margins free of tumor) and tumor type. Survival differed according to tumor cell type (tumor grade was not available). Patients with chondrosarcoma and dermat‐ofibrosarcoma had survival approaching 100%. Patients with malignant fibrous histiocytoma (MFH) and fibrosarcoma (FSA) had intermediate survival of 60% to 70%. The worst survival, < 50% at 5 years, occurred in patients with osteosarcoma, an‐giosarcoma, and rhabdomyosarcoma in decreasing order. This suggests a rationale for identifying high‐risk patients for prospective adjuvant protocols. This sutdy emphasizes the value of recording uncommon tumors to provide relevant information for future study and possibly therapy.
Effect of advanced age and medical disease on the outcome of microvascular reconstruction for head and neck defects
Authors: Shestak Kenneth C. , Jones Neil Ford , Wu Wayne , Johnson Jonas T. , Myers Eugene N. 
Published: February 2007

AbstractDuring the 5‐year period from July 1984 to 1988, 72 patients over the age of 50 underwent microvascular free tissue transfers for head and neck reconstruction. There were 22 patients aged 50‐59 years, 31 patients aged 60‐69 years, and 19 patients aged 70‐79 years. Seventy of these procedures (97%) were done at the time of ablative surgery utilizing a two‐team approach. There was 1 total flap loss for a flap viability rate of 99% (73/74). There were 46 complications in 40 patients: 21 surgical and 25 medical. Twelve of the surgical complications required reoperation for a major surgical complication rate of 16%. Major medical complications developed in 12 patients (16%). Medical complications more commonly were observed in patients aged 60‐69 years who had significant preoperative comorbidity and were classified as ASA class 3 or greater. There were 5 postoperative deaths for a mortality rate of 7%. Advanced chronologic age does not compromise the technical success of microsurgical free tissue transfer in the elderly patient with head and neck cancer. The risk of medical complications is significant and is directly related to concurrent illness of the individual patient rather than to age alone.
Synovial sarcoma of the head and neck
Authors: Bukachevsky Roman P. , Pincus Robert L. , Shechtman Frank G. , Sarti Edward , Chodosh Paul 
Published: February 2007

AbstractPrimary synovial sarcoma is an unusual tumor of the head and neck. Fewer than 75 cases have been reported in the literature. We have treated 7 additional cases; 3 in the hypopharynx, 2 in the parapharyngeal space, 1 in the oral pharynx and 1 in the posterior triangle of the neck. An enlarging cervical mass, voice change, and dysphagia were among the presenting complaints. CT revealed solitary nonhomogenous tumors from 3 to 7 cm in diameter. Microscopically, all cases showed a biphasic cellular pattern verified by immunohistochemical staining. Multimodality treatment consisted of surgery and postoperative radiation therapy with 3 patients receiving chemotherapy. Although the original pathology report was incorrect in 3 cases, clinical suspicion for synovial sarcoma ensured proper diagnosis.
Carcinoma of the uvula and midline soft palate: Indication for neck treatment
Authors: Har‐El Gady , Shaha Ashok , Chaudry Rashid , Hadar Tuvia , Krespi Yosef P. , Lucente Frank E. 
Published: February 2007

AbstractAccording to common classification and staging systems, tumors of the uvula and soft palate are included in the group of oropharyngeal cancers. As such, the same staging systems apply and therapeutic decisions are made accordingly. Our experience with small tumors of the uvula and midline soft palate has shown that these common rules may not apply in these anatomical sites. A multicenter retrospective study was performed to examine the aspects of presentation and clinical course of tumors of the uvula. Only patients with small tumors, less than 2.0 cm in diameter, were included. Twenty‐three cases were reviewed. Eleven (47.8%) patients had clinical or radiologic evidence of neck disease on presentation. Five of 12 (41.7%) patients who presented with negative neck were found eventually to have neck disease. Eight patients had cervical recurrence. Only one patient had local recurrence. We suggest that attention may need to be directed to the treatment of the neck of all tumors of the uvula and midline soft palate, regardless of size.
Primary reconstruction of head and neck cancer with anterior rib, osteomyocutaneous composite flap
Authors: Bhathena Hosi M. , Kavarana Naozer M. 
Published: February 2007

AbstractThe anterior rib, osteomyocutaneous composite flap (AROCF) incorporating both vessels, supracostal and intercostal, has been harvested for primary reconstruction in advanced head and neck cancer patients. The adequacy of the periosteal circulation alone for the successful free osseous transfer has been well proved.1,2 The available length of the internal mammary vessels is sufficient for the successful microvascular anastomosis in the neck. This same AROCF can be used as a pedicled flap based on the pectoralis major musculo‐vascular pedicle for successful primary reconstruction in cases in which it is deemed unsuitable for use as a free flap. This is possible because of the unique functional blood supply of the rib.
Sublethal damage repair in squamous cell carcinoma cell lines
Authors: Pekkola‐Heino Kirsi , Kulmala Jarmo , Grenman Reidar 
Published: February 2007

AbstractSquamous cell carcinoma (SCC) cell lines recently established from head and neck tumors were studied for their capability of repairing sublethal radiation induced damage (SLDR). Total doses of 1.25, 2.50, 5.00, and 7.50 Gy were used either as a single dose or split in two equal fractions with a 24 h interval. Cell survival was determined using a 96‐well plate clonogenic assay based on limiting dilution. Survival data was fitted by linear quadratic model, and the area under the survival curve (AUC) was obtained with numerical integration. The amount of SLDR was expressed as AUC‐ratio comparing survivals from split dose vs single dose experiments.SLDR capacity was observed to vary markedly between individual cell lines (AUC‐ratios 1.0‐1.5). The relatively radiationsensitive cell lines had a tendency toward higher SLDR proficiency (correlation coefficient 0.85). The differences in repair capacity could not be explained by the differences in doubling times of the cell lines. The inverse relationship between SLDR capacity and inherent radiosensitivity could explain the poor radiocurability of the sensitive donor tumors. Two of the most resistant cell lines were found SLDR deficient. This is a novel finding, since SLDR has been previously reported in all studied cells.
Value of clinical follow‐up for local nasopharyngeal carcinoma relapse
Authors: Sham Jonathan S. T. , Choy D. , Wei W. I. , Yau C. C. 
Published: February 2007

AbstractThree hundred seventy‐nine new patients with nasopharyngeal carcinoma (NPC) were followed clinically and the physical examination, including that of the nasopharynx by indirect mirror for symptoms after treatment. At the time of analysis, with a median follow‐up of 34.8 months, 47 patients had developed recurrent disease in the nasopharynx and in the immediately adjacent regions. In 31 patients the first clinical features to suggest local recurrence were progressive symptoms (group A). In another 13 patients recurrence of tumor in the nasopharynx was detected by indirect mirror examination (group B). In the remaining three patients, the diagnosis was made during investigation for neck node recurrence. The more common symptoms at diagnosis of local recurrence were headache; cranial nerve palsy involving the third, fourth, fifth, and sixth nerves; and ear and nasal symptoms. Group B patients tended to have less of these symptoms. The presence of tumor was confirmed by fiberscopic examination and biopsy in all group B patients and 14 of 31 group A patients, the tumor was submucosal in the remaining 17 group A patients. The recurrence in group B patients was diagnosed significantly earlier than the group A patients (p = 0.0294), and group A patients suffered from more invasive and extensive disease in comparison with group B patients (p = 0.0044). There were significantly less patients in group A who were amenable to curative brachytherapy (p = 0.0280). Clinical follow‐up for local NPC recurrence was found to be useful. More frequent use of fiberscopic examination in the follow‐up, especially for those not adequately examined by indirect mirror examination, will improve the detection rate. Cross‐sectional imaging techniques and the monitoring of tumor markers may supplement clinical and fiberscopic examinations. An algorithm for diagnosing recurrent NPC and possible treatment are suggested.
Embolization of the ophthalmic artery for control of epistaxis: Report of two cases
Authors: Moser Franklin G. , Rosenblatt Marjorie , De La Cruz Francisco , Silver Carl , Burde Ronald M. 
Published: February 2007

AbstractEmbolization of the internal maxillary artery, an accepted method for control of severe or recurrent posterior epistaxis, usually involves the ipsilateral artery, but occasionally the contralateral vessel and the facial arteries as well. Such endovascular treatment may fail if the vascular supply to the bleeding vessels originates in derivative branches of the ophthalmic artery. We report two unusual cases in which embolization of the ophthalmic artery was performed to control epistaxis. The first patient had a prosthetic eye. In the second, sight in one eye was sacrificed after careful consideration in order to prolong life. © 1992 John Wiley & Sons, Inc.
Association between malignancies of the upper aerodigestive tract and uterine cervix
Authors: Spitz Margaret R. , Sider Joanne G. , Schantz Stimson P. , Newell Guy R. 
Published: February 2007

AbstractCancers of the cervix and buccal cavity share histologic, epidemiologic, and exposure characteristics. In particular, cigarette smoking and human papillomavirus (HPV) have been cited as etiologic cofactors of both malignancies. Using incidence data from the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute for the years 1973 through 1984, we evaluated the incidence of second cancers of the buccal cavity following an initial cervical cancer. Standardized incidence ratios (SIR) were uniformly elevated for both white (SIR = 2.0), and black (SIR = 3.5) women. There were also elevated risks for the development of cervical cancer following an initial buccal cavity cancer (SIRs = 3.3 and 2.5, respectively). A similar pattern was evident for laryngeal cancer among white women. HPV transmission could account in part for the paired occurrence of these two anatomically distinct cancer sites. Cigarette smoking could act as a synergistic cofactor in the malignant transformation of viral genome‐harboring tissue. © 1992 John Wiley & Sons, Inc.
Sarcoidosis masquerading as a parathyroid adenoma
Authors: Nabriski Dan , Bendahan Jose , Shapiro Menachem S. , Freund Uri , Lidor Cobi 
Published: February 2007

AbstractTwo patients presented with a presumptive diagnosis of hyper‐parathyroidism. Surgically excised “parathyroid glands” were found to be, in fact, large lymph nodes with sarcoid granulomata. In one patient, the preoperative localization of the “parathyroid adenoma” was based on scintigraphy (thallium‐technetium subtraction imaging) and sonography procedures. The differential diagnosis of hypercalcemia, and positive scintigraphy‐sonography studies, must include sarcoidosis in an isolated cervical lymph nodes. © 1992 John Wiley & Sons, Inc.
Multifocal adult rhabdomyomas of the head and neck
Authors: Shemen Larry , Spiro Ronald , Tuazon Ricardo 
Published: February 2007

AbstractRhabdomyomas are usually found in the myocardium. Of the extracardiac sites, the head and neck is the most frequent region where this rare tumor arises. Multifocal head and neck lesions have only been described in 11 cases. We herein present two additional multifocal lesions. © 1992 John Wiley & Sons.
Dual free flap transfer using forearm flap for mandibular reconstruction
Authors: Nakatsuka Takashi , Harii Kiyonori , Yamada Atsushi , Ueda Kazuki , Ebihara Satoshi 
Published: February 2007

AbstractTo reconstruct a composite mandibular defect, we have simultaneously transferred a vascularized bone graft or osteocutaneous flap together with a forearm flap. The radial forearm flap, being thin, pliable, and having a long vascular stalk, served as mucosal lining and/or an interpositional flap acting as a vascular bridge. Between 1982 and 1989, we used this procedure in 17 patients with a mandibular defect or deformity which developed following treatment of oral cancer. Our clinical experience has demonstrated that this dual free tissue transfer has many advantages. It is useful for obtaining a good alveolar ridge in patients with a composite mandibular defect. It is applicable in cases where only a single pair of recipient vessels are present and may be useful when the recipient vessels are positioned some distance from the defect. © 1992 John Wiley & Sons, Inc.
Sister chromatid exchange frequencies in carcinoma of the human oral cavity: Effect of treatment
Authors: Ankathil Ravindran , Vijayakumar T. , Bhattathiri V. N. , Nair M. Krishnan 
Published: February 2007

AbstractSpontaneous and mitomycin‐C‐induced sister chromatid exchange frequencies were studied in the lymphocytes of 25 oral cancer patients. For these patients, the mean spontaneous SCE value was 8.31 (±SD), which was significantly higher than the value of 6.60 (±SD) obtained for the controls (p < 0.001). But there was no significant difference between the Mitomycin C induced mean SCE values of oral cancer patients and controls. Seven of these 25 oral cancer patients were selected for second sampling after surgical removal of the tumor. Six of these seven patients showed a decrease in mean SCE/cell value following surgery, which was almost equal to the SCE values obtained for the controls. This indicates that the increased spontaneous SCE rates in oral cancer patients might be due to the metabolic stress imposed by the tumor on the host body or by some clastogenic product of the malignant cells. Surgical removal of the tumour might have resulted in normalization of the lymphocytic SCE rates in postoperatively studied patients. © John Wiley & Sons, Inc.
Management of squamous cell carcinoma of the floor of mouth
Authors: Rodgers Lawrence W. , Stringer Scott P. , Mendenhall William M. , Parsons James T. , Cassisi Nicholas J. , Million Rodney R. 
Published: February 2007

AbstractBetween 1964 and 1987, 194 patients with previously untreated squamous cell carcinoma of the floor of mouth were managed at the University of Florida. A retrospective analysis was undertaken in order to evaluate the treatment results and associated complication rates. Surgery or irradiation alone was found to result in similar local control rates for stage I and II lesions, whereas more advanced tumors had better local control rates with a combination of surgery and irradiation. Radiotherapy had a higher incidence of minor and moderate complications, whereas a greater number of severe complications occurred after surgery. We recommend surgery for early lesions due to the lower overall incidence of associated complications. Despite a higher risk of severe complications, combination therapy is recommended for more advanced lesions due to improved local control as compared to single modality therapy.
Surgery for parathyroid adenoma and hyperplasia: Relationship of histology to outcome
Authors: Hosking Shorland W. , Jones Hugh , Du Boulay Claire E. H. , McGinn Frances P. 
Published: February 2007

AbstractRecent histopathologic evidence challenges the teaching that enlargement of a solitary parathyroid gland is invariably caused by an adenoma, whereas multiple gland enlargement results from hyperplasia. We have re‐examined the parathyroid tissue obtained from 152 consecutive patients undergoing surgery for primary hyperparathyroidism and compared it with their clinical outcome. Our approach was to excise enlarged glands and biopsy the remainder. In 124 patients (82%) at least three glands were biopsied or removed. The ratio of adenoma to hyperplasia was reversed by our histologic re‐examination; adenomas were found in only 27 patients (25 single, two double), whereas hyperplasia was found in 117 patients (one gland, 87 patients; two glands, 16 patients; three glands, five patients; four glands, nine patients). Normal tissue only was reported in eight patients. During a 2‐year follow‐up, five patients (3%) developed hypocalcemia and none developed recurrent hypercalcemia. Our results indicate that a full neck exploration with removal of all enlarged glands is more important than the histologic diagnosis in planning a successful surgical strategy for primary hyperparathyroidism.
Phase II trial of recombinant interferon gamma in refractory undifferentiated carcinoma of the nasopharynx
Authors: Mahjoubi Raoudha , Bachouchi Mounir , Munck Jean‐Nicolas , Busson Pierre , Gasmi Jamel , Azli Nacer , Brandely Mande , Tursz Thomas , Cvitkovic Esteban , Armand Jean‐Pierre 
Published: February 2007

AbstractThe presence of Epstein–Barr virus (EBV) genomes in the DNA of tumor cells of undifferentiated carcinoma of nasopharyngeal type (UCNT), associated with significant lymphocytic infiltration of tumor led to therapeutic trials with interferon (IFN) because of its antiviral, antiproliferative, and immunomodulatory properties. Fourteen patients with histologically proven UCNT (2 had locoregional disease alone and 12 metastatic disease) who were refractory to conventional chemotherapy, were treated with IFN gamma 20 × 106 U twice a week. Treatment was well tolerated. No objective response were achieved in the 13 evaluated patients, and all patients progressed after a median treatment duration of 10 weeks (6–32). IFN gamma seems unable to induce antitumor activity alone in such heavily pretreated patients. Its possible place in the management of UCNT is probably earlier in the natural history of this disease.
Cancer of the larynx in Mexico: Review of 357 cases
Authors: Rodriguez‐Cuevas Sergio A. , Labastida Sonia 
Published: February 2007

AbstractDescriptions of the patients population suffering from carcinoma of the larynx are not common in Mexico. This article deals with the clinical features, treatment, and results of 357 cases of cancer of the larynx treated at the Hospital de Oncologia, Centro Medico Nacional, IMSS, during a 10‐year period. In this series, 68% of the patients were in advanced stage (T3–T4) at the time of diagnosis; nevertheless, a combination of surgery and radiotherapy achieved an actuarial 5‐year survival for the entire group of 77.5%. Metastatic cervical nodes and tracheotomy previous to the treatment were factors that influenced a poor prognosis (p = 0.01). The survival of cases in the early stages (T1–T2) of 95.2% is comparable to that reported by most authors. In 87.5% of the cases that develop recurrence, it appears during the first 24 months of control.
Immediate free flap mandibular reconstruction: Significance of adequate surgical margins
Authors: Schusterman Mark A. , Harris Scott W. , Raymond A. Kevin , Goepfert Helmuth 
Published: February 2007

AbstractThe pathologic records of 182 consecutive patients who had mandible resections were reviewed to determine the incidence of positive margins in the bone specimens and the risk factors associated with positive margins. Of the 182 cases reviewed, 82 (45%) were found to have involvement of the mandible at the time of resection and four (2%) were found to have positive margins. The predominant tumor histology was squamous cell carcinoma, 148 of 182 (81%), followed in frequency by osteosarcoma 12 of 182 (7%), salivary gland tumors 13 of 182 (7%), and miscellaneous other tumors nine of 182 (5%). Of the four tumors with positive margins, two (50%) were squamous cell carcinomas, one (25%) was an osteosarcoma, and one (25%) was a salivary gland tumor. All four tumors were large tumors that had failed to respond to previous therapy. All obviously involved the mandible at the time of presentation. This study demonstrates that the incidence of bone margin involvement after mandibulectomy is rare and predictable and that clinical selection of candidates for immediate reconstruction is reliable in preventing inappropriate use of free bone flaps in patients at risk for positive bone margins.
Radiotherapy for adenoid cystic carcinoma of the palate
Authors: Regine William F. , Mendenhall William M. , Parsons James T. , Stringer Scott P. , Cassisi Nicholas J. , Million Rodney R. 
Published: February 2007

AbstractThis is an analysis of 16 patients with adenoid cystic carcinoma of the palate who were treated with curative intent by radiotherapy alone (9) or surgery and radiotherapy (7). No patient received adjuvant chemotherapy. Follow‐up ranged from 3 years to 19 years with 69% of the patients having follow‐up of more than 5 years. Two patients in the radiotherapy alone group developed local recurrences, and both have had long‐term surgical salvage. No local failures were seen in the combined therapy group. Twelve patients (75%) are alive and disease‐free. Two patients died with distant disease, one within each treatment group. One patient in the combined therapy group is alive at 8 years with distant metastases, while one in the radiotherapy alone group died of intercurrent disease at 12 years. No significant complications were seen in either treatment group. The role of radiotherapy in the treatment of adenoid cystic carcinoma of the palate is reviewed.