bluuebunny/crossref_metadata_2025_split huggingface dataset:
Voting and Not Voting in Early 18th‐Century English Parliamentary Elections
Authors: Dudley Chris 
Published: February 2024

AbstractThis article uses data from 28 poll books to explore voter behaviour over time in early 18th‐century English parliamentary elections (from 1710 to 1735). Voters in this period exhibited a high degree of partisan loyalty from one election to the next. But voters were also quite likely to drop out of the electorate between elections. As a case study of Sussex elections in 1734 shows, even among voters who made a definite promise to vote for a given candidate or set of candidates, there was a significant proportion who did not vote. While some non‐voting can be explained as an attempt to avoid disobliging powerful patrons, this article argues that voters needed to be motivated to appear at the polls. The electoral culture of the early 18th century – treats, balls, public appearances by the candidates, etc. – should be understood as attempts to mobilise rather than to persuade potential voters.
Tory Travails and Collegiate Confusion: The Oxford University Election of 1722*
Authors: Aston Nigel 
Published: February 2024

AbstractIn terms of the unreformed franchise operative in the early 18th century, the University of Oxford made up an unusual parliamentary constituency. Here it was the votes of non‐resident members that could be decisive to the outcome if the seat was contested. In late Stuart and early Hanoverian Oxford, Tories were almost certain to be returned but, in the general election of 1722, the Tory vote was split between rival candidates offering a possible opening for Oxford Whigs. This essay considers the varieties of electoral behaviour inside the university at this time of exceptional political flux nationally, how the candidates confronted the practical problem of getting ‘outvoters’ into Oxford, and the extent to which the heads of the colleges could rely on a sufficiently stable corporate identity to have their resident members vote in an approved way. The 1722 general election again raised questions as to who exactly was entitled to vote in a university constituancy, how much illegal voting was going on, and whether it was in a candidate's best interests either to connive or draw attention to it. The eventual choices made by the Oxford electorate would signal where the university stood in the wider political picture of the early 1720s, how far it – and the varieties of toryism it contained – was prepared to endorse the legitimacy of the new Hanoverian order.
Factors associated with diabetic foot ulcers and lower limb amputations in type 1 and type 2 diabetes supported by real‐world data from the German/Austrian DPV registry
Authors: Eckert Alexander J. , Zimny Stefan , Altmeier Marcus , Dugic Ana , Gillessen Anton , Bozkurt Latife , Götz Gabriele , Karges Wolfram , Wosch Frank J. , Kress Stephan , Holl Reinhard W. ,   for the DPV‐Wiss‐Initiative
Published: February 2024

AbstractAimsDiabetic foot ulcer (DFU) is a leading cause of lower limb amputations in people with diabetes. This study was aimed to retrospectively analyze factors affecting DFU using real‐world data from a large, prospective central‐European diabetes registry (DPV [Diabetes‐Patienten‐Verlaufsdokumentation]).Materials and MethodsWe matched adults with type 1 (T1D) or type 2 diabetes (T2D) and DFU to controls without DFU by diabetes type, age, sex, diabetes duration, and treatment year to compare possible risk factors. Cox regression was used to calculate hazard ratios for amputation among those with DFU.ResultsIn our cohort (N = 63 464), male sex, taller height, and diabetes complications such as neuropathy, peripheral artery disease, nephropathy, and retinopathy were associated with DFU (all p < .001). Glycated hemoglobin (HbA1c) was related to DFU only in T1D (mean with 95% confidence interval [CI]: 7.8 [6.9–9.0] % vs 7.5 [6.8–8.5] %, p < .001). High triglycerides and worse low‐density lipoprotein/high‐density lipoprotein ratio were also associated with DFU in T1D, whereas smoking (14.7% vs 13.1%) and alcohol abuse (6.4% vs 3.8%, both p < .001) were associated with DFU in T2D. Male sex, higher Wagner grades, and high HbA1c in both diabetes types and insulin use in T2D were associated with increased hazard ratios for amputations.ConclusionsSex, body height, and diabetes complications were associated DFU risk in adults with T1D and T2D. Improvement in glycemic control and lipid levels in T1D and reduction of smoking and drinking in T2D may be appropriate interventions to reduce the risk for DFU or amputations.image
Evidence of content validity of the nursing diagnosis risk for unstable blood pressure
Authors: Silva Gabrielle P , Mendes Ryanne C. M. G. , Lopes Camila T , Lopes Marcos VO , Perrelli Jaqueline GA , Mangueira Suzana O , Linhares Francisca MP 
Published: February 2024

AbstractPurposeTo analyze evidence of content validity of the nursing diagnosis (ND) Risk for Unstable Blood Pressure in incarcerated women. MethodA methodological study assessing the content validity of an ND, was performed in Brazil, between June and September 2022, with 49 nurses as experts. The label, definition, and relevance of the 19 risk factors of the ND Risk for Unstable Blood Pressure were appraised. Based on the predictive diversity model, the content validity index (CVI) and respective 95% confidence intervals were calculated for each risk factor. A CVI ≥ 0.8 was considered adequate evidence of content validity.FindingsThe label and the definition of the diagnosis was reformulated. The relevance of 19 etiological factors showed a CVI ≥ 0.8. According to the recommendation of the panel of experts, one of the etiological factors was split in two and two label of etiological factors were changed.ConclusionsA new label (Risk for Imbalanced Blood Pressure), new definition, and 20 etiological factors (11 risk factors, five associated conditions, and four at‐risk populations) of the ND Risk for Unstable Blood Pressure in incarcerated women were considered valid.Implications for nursing practiceNANDA‐I accepted the proposal for this nursing diagnosis; hence this study contributed to updating the classification based on scientific evidence. This evidence will favor diagnostic reasoning and recognition of the diagnosis during clinical assessment, and support studies assessing the clinical validity of these elements in incarcerated women.
Phenological growth stages of cardamom (Elettaria cardamomum Maton): Detailed identification and description using the extended BBCH scale
Authors: Akshitha Hosahalli Jagannathagowda , Shivakumar Mundagodu Somashekar , Ankegowda Shettahallikoppalu Javaraiah 
Published: February 2024

AbstractCardamom (Elettaria cardamomum Maton) is an important spice crop with high market value. In this study, we describe the phenological growth stages of cardamom using a three‐digit extended Biologische Bundesanstalt, Bundessortenamt und CHemische Industrie (BBCH) scale, which includes eight principal growth stages, comprising four vegetative, two reproductive and two capsule development stages. Additionally, we identified 45 secondary stages within these principal growth stages, providing a comprehensive characterisation of the crop's growth progression, including bud development, leaf emergence, tillering and shoot development, while the reproductive stages included inflorescence emergence and flowering. The capsule development stage details the maturation process of capsules. The study also highlights the parallel occurrence of tillering, shoot development and inflorescence emergence stages during specific growth phases. The knowledge of growth stages facilitates timely interventions, optimising crop management strategies and enhancing overall crop productivity. Additionally, these findings offer valuable insights for breeding programmes and the selection of superior genotypes, contributing to the sustainable cultivation and economic viability of cardamom as an important export‐oriented spice crop.Highlights
BBCH scale provides uniform coding for different growth stages of cardamom.
Identified and described eight principal growth stages (PGS).
PGS comprises of 4 vegetative, 2 reproductive and 2 capsule development stages.
45 secondary stages were identified within 8 principal growth stages.
Tillering, shoot development and inflorescence emergence occurs parallelly.
S100A8‐enriched microglia populate the brain of tau‐seeded and accelerated aging mice
Authors: Gruel Roxane , Bijnens Baukje , Van Den Daele Johanna , Thys Sofie , Willems Roland , Wuyts Dirk , Van Dam Debby , Verstraelen Peter , Verboven Rosanne , Roels Jana , Vandamme Niels , Mancuso Renzo , Pita‐Almenar Juan Diego , De Vos Winnok H. 
Published: February 2024

AbstractLong considered to fluctuate between pro‐ and anti‐inflammatory states, it has now become evident that microglia occupy a variegated phenotypic landscape with relevance to aging and neurodegeneration. However, whether specific microglial subsets converge in or contribute to both processes that eventually affect brain function is less clear. To investigate this, we analyzed microglial heterogeneity in a tauopathy mouse model (K18‐seeded P301L) and an accelerated aging model (Senescence‐Accelerated Mouse‐Prone 8, SAMP8) using cellular indexing of transcriptomes and epitopes by sequencing. We found that widespread tau pathology in K18‐seeded P301L mice caused a significant change in the number and morphology of microglia, but only a mild overrepresentation of disease‐associated microglia. At the cell population‐level, we observed a marked upregulation of the calprotectin‐encoding genes S100a8 and S100a9. In 9‐month‐old SAMP8 mice, we identified a unique microglial subpopulation that showed partial similarity with the disease‐associated microglia phenotype and was additionally characterized by a high expression of the same calprotectin gene set. Immunostaining for S100A8 revealed that this population was enriched in the hippocampus, correlating with the cognitive impairment observed in this model. However, incomplete colocalization between their residence and markers of neuronal loss suggests regional specificity. Importantly, S100A8‐positive microglia were also retrieved in brain biopsies of human AD and tauopathy patients as well as in a biopsy of an aged individual without reported pathology. Thus, the emergence of S100A8‐positive microglia portrays a conspicuous commonality between accelerated aging and tauopathy progression, which may have relevance for ensuing brain dysfunction.
Dementia in Australia: Clinical recommendations post‐diagnosis
Authors: Foxe David , D'Mello Mirelle , Cheung Sau Chi , Bowen Julane , Piguet Olivier , Hwang Yun Tae 
Published: February 2024

AbstractThe delivery of a dementia diagnosis, the information provided, and the practical advice and support arranged can have a long‐lasting impact on patients and their families and deserves attention equal to that given to the assessment and investigation process. Patients and their families need a constructive yet sensitive conversation about the nature and cause of their difficulties, communicated in plain language, and tailored to their main concerns and needs. This conversation should lead to the provision of high‐quality, easily accessible information. Following this, clinicians may wish to consider broaching the following dementia topics: (1) pharmacological and non‐pharmacological interventions, (2) connection and integration with relevant organisations, (3, 4) application for formal support services and engagement with support teams, (5) safety in the home, (6, 7) financial planning, guardianship and legal matters, (8) driving eligibility, (9) support and education resources to family carers and (10) research initiatives and genetic information. Addressing these topics will contribute to improved disease management, which is likely to improve the dementia journey for the patient, their carer(s), and family.
Immune signatures predict response to house dust mite subcutaneous immunotherapy in patients with allergic rhinitis
Authors: Wang Nan , Song Jia , Sun Shi‐Ran , Zhu Ke‐Zhang , Li Jing‐Xian , Wang Zhi‐Chao , Guo Cui‐Lian , Xiang Wen‐Xuan , Tong Yun‐Long , Zeng Ming , Wang Heng , Xu Xiao‐Yan , Yao Yin , Liu Zheng 
Published: February 2024

AbstractBackgroundIdentifying predictive biomarkers for allergen immunotherapy response is crucial for enhancing clinical efficacy. This study aims to identify such biomarkers in patients with allergic rhinitis (AR) undergoing subcutaneous immunotherapy (SCIT) for house dust mite allergy.MethodsThe Tongji (discovery) cohort comprised 72 AR patients who completed 1‐year SCIT follow‐up. Circulating T and B cell subsets were characterized using multiplexed flow cytometry before SCIT. Serum immunoglobulin levels and combined symptom and medication score (CSMS) were assessed before and after 12‐month SCIT. Responders, exhibiting ≥30% CSMS improvement, were identified. The random forest algorithm and logistic regression analysis were used to select biomarkers and establish predictive models for SCIT efficacy in the Tongji cohort, which was validated in another Wisco cohort with 43 AR patients.ResultsPositive SCIT response correlated with higher baseline CSMS, allergen‐specific IgE (sIgE)/total IgE (tIgE) ratio, and frequencies of Type 2 helper T cells, Type 2 follicular helper T (TFH2) cells, and CD23+ nonswitched memory B (BNSM) and switched memory B (BSM) cells, as well as lower follicular regulatory T (TFR) cell frequency and TFR/TFH2 cell ratio. The random forest algorithm identified sIgE/tIgE ratio, TFR/TFH2 cell ratio, and BNSM frequency as the key biomarkers discriminating responders from nonresponders in the Tongji cohort. Logistic regression analysis confirmed the predictive value of a combination model, including sIgE/tIgE ratio, TFR/TFH2 cell ratio, and CD23+ BSM frequency (AUC = 0.899 in Tongji; validated AUC = 0.893 in Wisco).ConclusionsA T‐ and B‐cell signature combination efficiently identified SCIT responders before treatment, enabling personalized approaches for AR patients.
Pitch Black: How design entrepreneurs are rethinking race in post‐Katrina schools
Authors: Tompkins Christien 
Published: February 2024

AbstractPutting anthropologists of design in conversation with Black studies, this article demonstrates how a group of repentant education entrepreneurs in post‐Katrina New Orleans mobilized racialized affective and narrative surplus within an information economy based on design rituals and protocols. I examine how this splinter group of education reformers established design communities through ritualized “pitches” and show how the egalitarian aspirations of designers rely on forms of empathetic erasure rooted in narratives of spectacular violence and universalist assumptions about the motivations, behaviors, and capacities of so‐called users and so‐called designers. While it is easy to laud the “empathy principles” of design thinking for taking seriously the agency and intellectual capacity of its racialized “users,” this article shares anti‐Blackness theorists’ skepticism of liberal humanization projects and is concerned with the burdens that the relationship between designers and users entails. What is the human at the center of design? Humanity here is not a shared essence, nor an egalitarian relation, but in this instance marks a process through which surplus affect and the spectacle of Blackness is instrumentalized and transmuted into racial capital.
Most recently developed polyester polymer alloy dialyzer: A new medium cut‐off membrane?
Authors: Maduell Francisco , Rodríguez‐Espinosa Diana , Rodas Lida María , Gómez Miquel , Arias‐Guillén Marta , Fontseré Néstor , Vera Manel , del Carmen Salgado Maria , Rico Nayra , Broseta José Jesús 
Published: February 2024

AbstractBackgroundNew versions of the polyester polymer alloy (PEPA) membrane have appeared over the years, with increases in both the pore size and the amount of polyvinylpyrrolidone (PVP) to optimize hydrophilicity performance. This study aimed to assess the efficacy of the most recently developed PEPA dialyzer, the FDY series, in hemodialysis (HD) modality in terms of uremic toxin removal and albumin loss and to compare it with that of several high‐flux dialyzers currently used in HD and post‐dilution hemodiafiltration (HDF) treatments.MethodsA prospective study was carried out in 21 patients. All patients underwent six dialysis sessions with the same routine dialysis parameters; only the dialyzer and/or the dialysis modality varied: FX80 in HD, FDY 180 in HD, Clearum HS17 in HDF, Elisio 19H in HDF, Vitapes 180 in HDF, and FX80 in post‐dilution HDF. The reduction ratios (RR) of urea, creatinine, ß2‐microglobulin, myoglobin, κFLC, prolactin, α1‐microglobulin, α1‐acid glycoprotein, λFLC, and albumin were compared intraindividually. Dialysate albumin loss was also measured.ResultsBoth membranes FDY and FX80 are high‐flux dialyzers and are applied here in high‐flux HD. The average RR of β2‐microglobulin was slightly lower in the two HD treatments than in the HDF treatments. Comparison of dialysis treatments revealed that the PEPA FDY dialyzer in the HD modality was more effective than the FX80 dialyzer in high‐flux HD and was as effective as post‐dilution HDF, especially in terms of myoglobin, κFLC, prolactin, α1‐microglobulin, and λFLC RRs. The FDY treatments obtained similar albumin RR in blood and slightly higher dialysate albumin loss, although the values were clinically acceptable.ConclusionsThe most recently developed PEPA dialyzers in the HD modality were as effective as all treatments in the HDF modality and were clearly superior to high‐flux helixone HD treatment. These results confirm that this dialyzer should be categorized within the medium cut‐off (MCO) membrane classification.
Skin structure of the slow worm lizard Anguis fragilis (Anguidae, Sauria, Reptilia) with emphasis on the epidermal micro‐ornamentation in relation to the animal movements
Authors: Bonfitto Antonio , Randi Maria Roberta , Alibardi Lorenzo 
Published: February 2024

AbstractSkin structure of the slow worm lizard Anguis fragilis (Anguidae, Sauria, Reptilia) with emphasis on the epidermal micro‐ornamentation in relation to the animal movements (Acta Zoologica, Stockholm). The structure of the skin and superficial micro‐ornamentation in the slow worm Anguis fragilis, a limbless lizard with a fossorial activity, was examined using histology, immunofluorescence, scanning and transmission electron microscopy. The scales, with a triangular to trapezoidal shape, are very overlapped and interlocked to form a smooth surface and are reinforced by osteoderms. The epidermis shows a thin Oberhautchen layer merged with a thicker beta‐layer that contains corneous beta‐proteins. The SEM survey detects a smooth surface made of tile‐like patterned Oberhautchen cells with irregular perimeters that form an interlocking surface. Disk‐like sensory organs of 15–20 μm diameter are observed only on the head scales, the first to sense the environment and contact the ground. Numerous Oberhautchen denticles, namely corneous thorns of about 0.2–0.3 μm, adorn the caudally directed perimeter of Oberhautchen cells in the ventral scales of the trunk and tail. This microstructure may determine gripping and increased friction with the substrate during the lateral undulating and forward movements of the slow worm. TEM observations reveal sparse short serrated protrusions of Oberhautchen cells that are largely merged with the underlying beta‐cells. Altogether, the scale surface of the slow worm efficiently suites this limbless lizard to its environment and lifestyle.
Media exposure and preschoolers' social‐cognitive development
Authors: Lenhart Jan , Richter Tobias 
Published: February 2024

AbstractExposure to narratives may have beneficial effects on children's social‐cognitive development because narratives provide information about the social world and often require social understanding for story comprehension. In the current study, we examined the influence of narratives presented via different media (books, audiobooks, TV/films) on theory‐of‐mind performance and mental verb comprehension in a sample of 114 three‐ to six‐year‐old preschool children. Parents' reports on the number of (children's) books at home, the overall duration of TV/film and audio media exposure, the frequency of shared book reading, watching children's TV/films and audiobook listening, and parent–child discussions about media content were collected. Children's theory‐of‐mind performance and mental verb comprehension were measured as dependent variables. When gender, age, language skills and parental education were controlled, only the number of children's books, shared book reading frequency, audio‐media exposure and audiobook usage significantly predicted children's theory‐of‐mind scores. None of the media exposure or the parent–child discussion variables had significant incremental effects above the family and child characteristics on mental verb comprehension.
Lamin A K97E leads to NF‐κB‐mediated dysfunction of inflammatory responses in dilated cardiomyopathy
Authors: Sengupta Duhita , Sengupta Kaushik 
Published: February 2024

AbstractBackground InformationLamins are type V intermediate filament proteins underlying the inner nuclear membrane which provide structural rigidity to the nucleus, tether the chromosomes, maintain nuclear homeostasis, and remain dynamically associated with developmentally regulated regions of the genome. A large number of mutations particularly in the LMNA gene encoding lamin A/C results in a wide array of human diseases, collectively termed as laminopathies. Dilated Cardiomyopathy (DCM) is one such laminopathic cardiovascular disease which is associated with systolic dysfunction of left or both ventricles leading to cardiac arrhythmia which ultimately culminates into myocardial infarction.ResultsIn this work, we have unraveled the epigenetic landscape to address the regulation of gene expression in mouse myoblast cell line in the context of the missense mutation LMNA 289A<G (Lys97Glu) that is found in DCM‐afflicted patient with severe symptoms. Significant changes in H3‐specific epigenetic modifications indicated a dysregulation in transcription machinery which was investigated by RNA sequencing analysis. The major pathways involved in IL‐17 signaling, cellular response to interferon‐beta and gamma, cytokine production, and related pathways are found to be downregulated. Analysis of the promoter sequences of the genes in the abovementioned pathways led us to the master regulator NF‐κB and its regulatory network.ConclusionsWe report here for the first time that there is a significant downregulation of the NF‐κB pathway, which has been implicated in cardio‐protection elsewhere.SignificanceThis provides a new pathophysiological explanation that correlates an LMNA mutation and dilated cardiomyopathy.