bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of Life with Diabetes-associated Foot Complications: Comparison Between Lower-limb Amputation and Chronic Foot Ulceration
Authors: Boutoille David , Féraille Alexis , Maulaz Dominique , Krempf Michel 
Published: November 2008

Background: Diabetic foot complications result in huge costs for both society and individual patients. Because our team performs numerous amputations each year for complicated diabetic foot ulcers, we conducted a study comparing the quality of life of diabetic amputees with a non-amputee group experiencing a diabetic foot ulcer. The aim of this study was to get better comprehension of the influence of amputation on physical and social aspects of our patients' quality of life. Materials and Methods: This study evaluated the influence of amputation for a diabetic foot ulcer on quality of life. We compared patients having experienced an amputation for a diabetic foot ulcer at least 1 year before the study, and outpatients experiencing regular visits for a current foot ulcer with no previous history of amputation. Quality of life was reported using the Medical Outcome Study Short Form 36 item health survey (MOS SF-36). Results: Most of the chronic ulcers were neuroischemic (8/9). Except for the bodily pain, which was significantly higher in the ulcer group, no difference was found between the amputee and the ulceration-group, when considering the different items of the MOS-SF 36 scales. The ulceration-group had significantly more physical limitations and pain than the toe-or-transmetatarsal-amputation-group, whereas physical limitations were identical between the transtibial-amputation-group and the ulceration-group. Median scores were quite low in both groups, reflecting strong social and psychological consequences of diabetic foot ulcers. Global prognosis was bad with 56% of the amputees having experienced another major cardiovascular event within 20 months after amputation. Conclusion: Better understanding of the consequences of diabetic foot complications is important for the general population and especially general practitioners. Psychological evaluation and support is important before and after amputation since it is a traumatic step for patients. Level of Evidence: III, Retrospective Case Control Study
Shell Brace for Stage II Posterior Tibial Tendon Insufficiency
Authors: Krause Fabian , Bosshard Adrian , Lehmann Oliver , Weber Martin 
Published: November 2008

Background: The nonoperative treatment of posterior tibial tendon insufficiency (PTTI) can lead to unsatisfactory functional results. Short-term results are available but the impact on the evolution of the deformity is not known. To address these problems, a new brace for the flexible Stage II deformity was developed, and midterm followup was obtained. Materials and Method: In a prospective case series, eighteen patients (mean age 64.2 years; range, 31 to 82; four male, 14 female) with flexible Stage II PTTI were fitted with the new custom-molded foot orthosis. At latest followup of a mean of 61.4 (range, 20 to 87) months, functional results were assessed with the AOFAS ankle hindfoot score and clinical or radiographic progression was recorded. Results: The score improved significantly from a mean of 56 points (range, 20 to 64) to a mean of 82 points (range, 64 to 100, p < 0.001). Three patients (3/18, 16%) had a clinical progression to a fixed deformity (Stage III) and a radiographic increase of their deformity. All the other patients were satisfied with the brace's comfort and noted an improvement in their mobility. Complications were seen in three patients (3/18, 16%), and consisted of the development of calluses. Conclusion: The “shell brace” is a valuable option for nonoperative treatment of the flexible Stage II PTTI. Hindfoot flexibility was conserved throughout the observation period in all but three patients. Functional outcome and patient acceptance was above average. Problems were few, and closely associated with a progression to a fixed, Stage III deformity. Level of Evidence: II, Prospective Case Series
Modified Step-Cut Medial Malleolar Osteotomy for Osteochondral Grafting of the Talus
Authors: Lee Keun-Bae , Yang Hyun-Kee , Moon Eun-Sun , Song Eun-Kyoo 
Published: November 2008

Background: Osteochondral grafting for the treatment of osteochondral lesions of the talus (OLT) usually requires a medial malleolar osteotomy (MMO) to achieve adequate intraarticular exposure. This study describes the technique used and the results obtained using a modified step-cut MMO for osteochondral grafting of talar dome lesions. Materials and Method: Eleven feet in ten patients underwent modified step-cut MMO prior to osteochondral grafting for OLT. The patients included three women and seven men with a mean age of 40 (range, 20 to 51) years. Modified step-cut MMO consisted of an oblique osteotomy, which was made at approximately 45 degrees to the transverse plane of the proposed traditional step-cut osteotomy, and a vertical osteotomy to the axilla on the medial tibial plafond. Results: In all patients, modified step-cut MMO provided better perpendicular access to lesions than traditional step-cut osteotomy. In all cases, the osteochondral graft plug was accurately set perpendicular to the defect area, and all ten patients experienced uncomplicated osteotomy healing at a mean 8 weeks postoperatively without loss of reduction or malreduction. Conclusion: Modified step-cut MMO is an excellent, reproducible method for perpendicular access to a talar dome lesion. Level of Evidence: IV, Retrospective Case Study
Effects of ethyl benzoate on performance, morphology, and erosion of PLGA implants formed in situ
Authors: Astaneh R. , Erfan M. , Barzin J. , Mobedi H. , Moghimi HR. 
Published: November 2008

AbstractAn in situ forming implant (ISFI) is a novel drug delivery system used for protein and peptide delivery, especially for cancer treatment. An ISFI based on 33% (w/w) poly(D,L‐lactide‐co‐glycolide)(PLGA; 50:50)/3% (w/w) leuprolide acetate (LA)/64% (w/w) N‐methyl‐2‐pyrrolidone (NMP) was prepared for this study. After injection of the final formulation, which is a viscous liquid to an aqueous medium, it deforms to become a semisolid or solid matrix. The performance of this matrix was investigated on the basis of peptide release from it. Erosion and morphology of ISFI were also studied. The effects of adding 12.8% (w/w) ethyl benzoate (EB) as a rate‐modifying agent on performance, erosion, and morphology of ISFI were assessed. The implant containing EB showed very low burst release (5.53% ± 0.82%) and the morphology turns to closed pore‐like structures. After adding EB, the morphology turns to closed pore‐like structures. This type of morphology has very close relation to the performance of the implant as well. Finally, the effect of EB on performance, erosion, and morphology is explained by means of solvent–nonsolvent affinity, water permeation, and the rate of phase inversion. © 2008 Wiley Periodicals, Inc. Adv Polym Techn 27:17–26, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/adv.20114
Integration of methanation into the hydrogenation process of benzoic acid
Authors: Zong Baoning , Zhang Xiaoxin , Qiao Minghua 
Published: November 2008

AbstractThe traditional industrial process for hydrogenation of benzoic acid to cyclohexanecarboxylic acid (CCA) has drawbacks of low‐activity and fast deactivation of the Pd/C catalyst due to the poisoning of CO arising from the decarboxylation of CCA. A novel rapidly quenched skeletal NiCrFe promoter (RQ NiCrFe) is developed for the methanation of CO to harmless CH4. Evaluations in bench‐scale autoclave and in traditional industrial equipment verified that RQ NiCrFe was very effective in promoting the activity of the Pd/C catalyst in the hydrogenation of benzoic acid. In order to solve the catalyst recycle and separation problem introduced by RQ NiCrFe, the industrial process was modified by incorporating a hydraulic cyclone and a magnetic separator to the separation unit. The modified process showed merits of lower costs of catalyst and operation, higher productivity, and better product purity than the traditional process. © 2008 American Institute of Chemical Engineers AIChE J, 2009
An ecosystem modelling approach to deriving viable harvest strategies for multispecies management of the Northern Gulf of California
Authors: Lercari Diego , Arreguín‐Sánchez Francisco 
Published: November 2008

Abstract
An ecosystem analysis was developed focusing on resource exploitation and biodiversity conservation for the Northern Gulf of California. The main tools employed were a trophic ecosystem model and time dynamic simulations.
The ecosystem was represented by an Ecopath model that included 34 functional groups, from primary producers to top predators. It included relevant species in the area such as commercially important shrimp (e.g. Litopenaeus stylirostris) and highly endangered species (Phocoena sinus and Totoaba macdonaldi).
Temporal simulations of changing fishing effort allowed the evaluation of fishing impact on the ecosystem components and, particularly, on protected species. Formal optimization methods were applied with the purpose of searching viable temporal patterns of fishing effort that might minimize social, economic and conservationist conflicts in the area.
The results of those simulations showed the capability of the model to represent reference temporal series of relative biomass. The search for viable fishing strategies resulted in effort allocation consistent with those proposed by other studies; that is, a decrease in the industrial shrimp fleet (35–65%), a decrease in the gillnet fishing fleet (52–57%), and an increase of the artisanal shrimp fishery (63–222%).
The main conflicts in the Northern Gulf of California seem to take place between social and conservation interests, while the economic and ecological benefits seem to be relatively independent. The next steps towards conflict resolution and ecosystem management should consider the design and operation of MPAs already established in the region.
Copyright © 2008 John Wiley & Sons, Ltd.
Domestic abuse experienced by young people living in families with alcohol problems: results from a cross‐european study
Authors: Velleman Richard , Templeton Lorna , Reuber Danielle , Klein Michael , Moesgen Diana 
Published: November 2008

AbstractThis paper presents findings from the European Union (EU) DAPHNE project ALC‐VIOL (2005–07). The project involved ten EU states (Germany, Austria, England, Finland, Hungary, Ireland, Malta, Netherlands, Poland and Spain). The research involved interviews with young people aged 12–18 from Germany, Poland, Spain, England and Malta on their experiences of living with parental alcohol misuse and parental violence. The children all had parents involved in treatment for alcohol problems. The study highlights the stressful experiences these children underwent, the effects on them, their coping strategies, and the support that they received and/or wished for, and underlines the need for a more coherent approach to help these children. Copyright © 2008 John Wiley & Sons, Ltd.
Evaluation of an intensive family preservation service for families affected by parental substance misuse
Authors: Forrester Donald , Copello Alex , Waissbein Clara , Pokhrel Subhash 
Published: November 2008

AbstractParental misuse of drugs or alcohol is recognised to be an issue for a high proportion of families to known social services, and for many children who enter care. However, there is limited research on what is effective in working with such families. This article reports on an evaluation of an Intensive Family Preservation Service (named ‘Option 2’) aimed at families in which parents misuse substances and children are considered at risk of entering care. The study used mixed methods. A quasi‐experimental element compared solely data relating to care entry (e.g. how long children spent in care and its cost) for Option 2 children (n = 279) and a comparison group of referrals not provided with the service (n = 89) on average 3.5 years after referral. It found that about 40 per cent of children in both groups entered care, however Option 2 children took longer to enter, spent less time in care and were more likely to be at home at follow‐up. As a result, Option 2 produced significant cost savings. A small‐scale qualitative element of the study involved interviews with 11 parents and seven children in eight families. The findings suggested that Option 2 was a highly professional and appreciated service. For some families it achieved permanent change. For others, particularly those with complex and long‐standing problems, significant positive changes were not sustained. The implications for services designed to prevent public care, particularly where there are substance misuse issues, are discussed and recommendations for policy and evaluation made. Copyright © 2008 John Wiley & Sons, Ltd.
Analysis of Specific Mutants in the Lasalocid Gene Cluster: Evidence for Enzymatic Catalysis of a Disfavoured Polyether Ring Closure
Authors: Smith Luke , Hong Hui , Spencer Jonathan B. , Leadlay Peter F. 
Published: November 2008

AbstractLasalocid is a highly atypical polyether ionophoric antibiotic, firstly because it contains a type of aromatic ring normally associated with fungal polyketides, and secondly because the formation of its tetrahydropyran ring appears to contravene Baldwin's rules, which predict the kinetically preferred routes for cyclisation reactions in organic chemistry. The lasalocid biosynthetic gene cluster has been cloned from Streptomyces lasaliensis, and the las locus (73 533 bp) was found to contain seven modular polyketide synthase (PKS) genes, including all the activities necessary for the synthesis of the aromatic moiety. Specific deletion from the gene cluster of the flanking lasC gene, which is predicted to encode a flavin‐linked epoxidase, abolished production both of lasalocid and of the minor cometabolite iso‐lasalocid without leading to accumulation of an identifiable intermediate; this suggests that oxidative cyclisation to form the polyether rings takes place on the PKS before release of the full‐length polyketide product. Meanwhile, a mutant in which the adjacent epoxide hydrolase lasB had been deleted produced iso‐lasalocid only. Iso‐lasalocid differs from lasalocid in the replacement of the tetrahydropyran ring by a tetrohydrofuran ring and represents the kinetically favoured product of cyclisation. The LasB epoxide hydrolase is therefore directly implicated in control of the stereochemical course of polyether ring formation during lasalocid biosynthesis.
Major 30‐day complications after radical radiotherapy
Authors: Alibhai Shabbir M. H. , Leach Marc , Warde Padraig 
Published: November 2008

AbstractBACKGROUND:Radiotherapy (RT) is used commonly to treat localized prostate cancer, particularly among older men and men with comorbid illnesses. Few population‐based studies have reported on the rates of major short‐term complications that lead to hospitalization after radiotherapy.METHODS:In this study, the authors identified all men with nonmetastatic prostate cancer who received RT between 1990 and 1999 in Ontario, Canada. Patients who underwent a prior prostate‐directed surgery were excluded. Mortality and complications after RT were examined by using administrative data. A comprehensive list of 7 categories of complications was developed by combining published lists from radical prostatectomy series with input from experts. Logistic regression was used to analyze the relations between complications (that occurred within 30 days of RT) and clinical factors. A similar analysis was performed among men who underwent radical prostatectomy during the same period.RESULTS:There were 7661 men (mean age, 69 years) identified who received RT. Nine patients (0.1%) died within 30 days of RT. Any complication within 30 days of RT was experienced by 6.5% of patients. In analyses that were adjusted for year of treatment, increasing age was associated with any, respiratory, bleeding, genitourinary, and miscellaneous medical complications (P<.02) but not with cardiac, vascular, or bowel complications. Over time, any, cardiac, vascular, and genitourinary complications decreased, but the other 4 categories of complications did not decrease. Despite being older and having more comorbidity, men who received RT had lower complication rates in each category compared with 11,010 men who underwent radical prostatectomy.CONCLUSIONS:Short‐term complications that required hospital‐based management were relatively uncommon after RT, commonly increased with patient age, and generally declined over time. Cancer 2009. © 2009 American Cancer Society.
Limited prognostic value of the 2004 International Union Against Cancer staging classification for adrenocortical carcinoma
Authors: Fassnacht Martin , Johanssen Sarah , Quinkler Marcus , Bucsky Peter , Willenberg Holger S. , Beuschlein Felix , Terzolo Massimo , Mueller Hans‐Helge , Hahner Stefanie , Allolio Bruno ,   for the German Adrenocortical Carcinoma Registry Group and the European Network for the Study of Adrenal Tumors
Published: November 2008

AbstractBACKGROUND:Adrenocortical carcinoma (ACC) is a rare malignancy, and it was only in 2004 that the International Union Against Cancer (UICC) defined TNM criteria and published the first staging classification. However, to date, the prognostic value of the proposed classification has not been evaluated.METHODS:The German ACC Registry comprising 492 patients was searched for patients who were diagnosed between 1986 and 2007 with detailed information on primary diagnosis and a minimum follow‐up of 6 months. Patients were assigned to UICC tumor stage, and disease‐specific survival (DSS) was assessed. In addition, the contribution of potential risk factors for DSS was evaluated.RESULTS:In total, 416 patients with a mean follow‐up of 36 months met the inclusion criteria (stage I, n = 23 patients; stage II, n = 176 patients; stage III, n = 67 patients; stage IV, n = 150 patients). Kaplan‐Meier analysis revealed a stage‐dependent DSS. However, DSS in patients with stage II ACC did not differ significantly from DSS in patients with stage III ACC (hazard ratio, 1.38; 95% confidence interval, 0.89‐2.16). Furthermore, patients who had stage IV ACC without distant metastases had an improved DSS compared with patients who had metastatic disease (P = .004). An analysis of different potential risk factors for defining stage III ACC revealed important roles in DSS for tumor infiltration in surrounding tissue, venous tumor thrombus (VTT), and positive lymph nodes; whereas tumor invasion in adjacent organs carried a prognosis similar to that of infiltration in surrounding tissue only.CONCLUSIONS:The 2004 UICC staging classification for ACC has significant limitations. On the basis of the current analysis, a revised classification with superior prognostic accuracy is proposed (the European Network for the Study of Adrenal Tumors classification). In this system, stage III ACC is defined by the presence of positive lymph nodes, infiltration of surrounding tissue, or VTT; and stage IV ACC is restricted to patients with distant metastasis. Cancer 2009. © 2009 American Cancer Society.
Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways
Authors: Long Jason E. , Swan Christo , Liang Winnie S. , Cobos Inma , Potter Gregory B. , Rubenstein John L.R. 
Published: November 2008

AbstractHere we define the expression of ≈100 transcription factors in progenitors and neurons of the developing basal ganglia. We have begun to elucidate the transcriptional hierarchy of these genes with respect to the Dlx homeodomain genes, which are essential for differentiation of most GABAergic projection neurons of the basal ganglia. This analysis identified Dlx‐dependent and Dlx‐independent pathways. The Dlx‐independent pathway depends in part on the function of the Mash1 b‐HLH transcription factor. These analyses define core transcriptional components that differentially specify the identity and differentiation of the striatum, nucleus accumbens, and septum. J. Comp. Neurol. 512:556–572, 2009. © 2008 Wiley‐Liss, Inc.
Tyramine as an independent transmitter and a precursor of octopamine in the locust central nervous system: An immunocytochemical study
Authors: Kononenko Natalia L. , Wolfenberg Heike , Pflüger Hans‐Joachim 
Published: November 2008

AbstractOctopamine and its precursor tyramine are biogenic amines that are found ubiquitously in insects, playing independent but opposite neuromodulatory roles in a wide spectrum of behaviors, ranging from locomotion and aggression to learning and memory. We used recently available antibodies to octopamine and tyramine to label the distribution of immunoreactive profiles in the brain and ventral nerve cord of the locust. In the brain and all ventral cord ganglia all known octopaminergic neurons were labeled with both the tyramine and octopamine antisera. In the brain the subesophageal ganglion and all fused abdominal ganglia we found somata that were only labeled by the tyramine antibody. Some prominent architectural features of the brain, like the protocerebral bridge, the central body, and associated neuropils, also contain intensely labeled tyramine‐immunoreactive fibers. In addition, tyraminergic fibers occur in all ganglia of the ventral cord. For known octopaminergic neurons of the thoracic ganglia, octopamine‐immunoreactivity was confined to the cell body and to the varicosities or boutons, whereas fiber processes always expressed tyramine‐immunoreactivity. The distribution of the tyramine and octopamine content within these neurons turned out to be dependent on how the animal was handled before fixation for immunocytochemistry. We conclude that tyramine is an independent transmitter in locusts, and that in octopaminergic neurons the ratio between octopamine and its precursor tyramine is highly dynamic. J. Comp. Neurol. 512:433–452, 2009. © 2008 Wiley‐Liss, Inc.
Distribution of organic cation transporter 3, a corticosterone‐sensitive monoamine transporter, in the rat brain
Authors: Gasser Paul J. , Orchinik Miles , Raju Ilangovan , Lowry Christopher A. 
Published: November 2008

AbstractOrganic cation transporter 3 (OCT3) is a high‐capacity, low‐affinity transporter that mediates bidirectional, sodium‐independent transport of dopamine, norepinephrine, epinephrine, serotonin, and histamine. OCT3‐mediated transport is directly inhibited by corticosterone, suggesting a potential role for the transporter in mediating some of the effects of stress and glucocorticoids on monoaminergic neurotransmission. To elucidate the importance of OCT3 in clearance of extracellular monoamines in the brain, we used immunohistochemical techniques to describe the distribution of OCT3‐like‐immunoreactive (OCT3‐ir) cells throughout the rostrocaudal extent of adult male rat brains. OCT3‐ir cell bodies were widely distributed throughout the brain, with the highest densities observed in the superior and inferior colliculi, islands of Calleja, subiculum, lateral septum, lateral and dorsomedial hypothalamic nuclei, and granule cell layers of the main and accessory olfactory bulbs, the cerebellum, and the retrosplenial granular cortex. OCT3‐ir cells and/or fibers were also observed in circumventricular organs, and OCT3‐ir ependymal cells were observed in the linings of all cerebral ventricles. The widespread distribution of OCT3‐ir cell bodies, including regions receiving dense monoaminergic projections, suggests an important role for this transporter in regulating extracellular concentrations of monoamines in the rat brain and is consistent with the hypothesis that corticosterone‐induced inhibition of OCT3‐mediated transport may contribute to effects of acute stress or corticosterone on monoaminergic neurotransmission. J. Comp. Neurol. 512:529–555, 2009. © 2008 Wiley‐Liss, Inc.