bluuebunny/crossref_metadata_2025_split huggingface dataset:
Agomelatine: A novel mechanism of antidepressant action involving the melatonergic and the serotonergic system
Authors: San Luis , Arranz Belen 
Published: June 2008

AbstractThe clinical finding that depressive disorders are often associated with desynchronization of internal rhythms has encouraged the idea that resetting normal circadian rhythms may have antidepressant potential. Agomelatine, a naphthalene analog of melatonin, is both an agonist of human cloned melatonergic MT1 and MT2 receptors and a serotonin 5-HT2C receptor antagonist. Agomelatine combines zeitgeber (synchroniser of the circadian system) activity with neurotransmitter augmentation properties (enhances the levels of dopamine and noradrenaline in frontal cortex). The efficacy of agomelatine in treating depression has been shown in three short-term, pivotal, randomized, placebo–controlled studies. These studies have demonstrated agomelatine to be efficacious in Major Depressive Disorder at the standard dose of 25 mg/day, with the possibility of increasing doses to 50 mg/day in those patients with insufficient improvement. The number of adverse events during the treatment period was comparable to placebo. Four studies have shown the positive effect of agomelatine on sleep continuity and quality and shortening of sleep latency. Despite these promising data, further studies are needed to examine agomelatine's efficacy over a longer treatment period.
Specificity of the inhibitory effects of Dad on TGF‐β family type I receptors, Thickveins, Saxophone, and Baboon in Drosophila
Authors: Kamiya Yuto , Miyazono Kohei , Miyazawa Keiji 
Published: June 2008

MINT‐6596817:

Smad7 (uniprotkb:O35253) physically interacts (MI:0218) with Sax (uniprotkb:Q7JQ39) by anti tag coimmunoprecipitation (MI:0007)
MINT‐6596699:

Dad (uniprotkb:O15968) physically interacts (MI:0218) with Sax (uniprotkb:Q7JQ39) by anti tag coimmunoprecipitation (MI:0007)
MINT‐6596805:

Smad7 (uniprotkb:O35253) physically interacts (MI:0218) with Thv (uniprotkb:Q95SI0) by anti tag coimmunoprecipitation (MI:0007)
MINT‐6596829:

Smad7 (uniprotkb:O35253) physically interacts (MI:0218) with Babo (uniprotkb:A1Z7L9) by anti tag coimmunoprecipitation (MI:0007)
MINT‐6596719:

Dad (uniprotkb:O15968) physically interacts (MI:0218) with Thv (uniprotkb:Q95SI0) by anti tag coimmunoprecipitation (MI:0007)
Stathmin/Op18 is a novel mediator of vinblastine activity
Authors: Devred Francois , Tsvetkov Philipp O. , Barbier Pascale , Allegro Diane , Horwitz Susan Band , Makarov Alexander A. , Peyrot Vincent 
Published: June 2008

MINT‐6603918:

tubulin beta (uniprotkb:Q9H4B7), tubulin alpha (uniprotkb:Q71U36) and stathmin (uniprotkb:Q71U36) physically interact (MI:0218) by cosedimentation (MI:0027)
MINT‐6603930:

tubulin alpha (uniprotkb:Q71U36) physically interacts (MI:0218) with tubulin beta (uniprotkb:Q9H4B7) and stathmin (uniprotkb:P16949) by isothermal titration calorimetry (MI:0065)
Flightless‐I, a gelsolin family member and transcriptional regulator, preferentially binds directly to activated cytosolic CaMK‐II
Authors: Seward Matthew E. , Easley Charles A. , McLeod Jamie J. , Myers Alexandra L. , Tombes Robert M. 
Published: June 2008

MINT‐6603828:

delta CaMK-II (uniprotkb:Q6PHZ2) binds (MI:0407) to Flightless-I (uniprotkb:Q9JJ28) by anti bait coimmunoprecipitation (MI:0006)
MINT‐6603847:

delta CaMK-II (uniprotkb:Q6PHZ2) phosphorylates (MI:0217) MAP2 (uniprotkb:P20357) by protein kinase assay (MI:0424)
MINT‐6603768:

beta CaMK-II (uniprotkb:P28652) physically interacts (MI:0218) with Flightless-I (uniprotkb:Q9JJ28) by anti bait coimmunoprecipitation (MI:0006)
MINT‐6603759, MINT‐6603776, MINT‐6603786:

delta CaMK-II (uniprotkb:Q6PHZ2) physically interacts (MI:0218) with Flightless-I (uniprotkb:Q9JJ28) by anti bait coimmunoprecipitation (MI:0006)
MINT‐6603724:

CaMK-II delta (uniprotkb:Q6PHZ2) physically interacts (MI:0218) with beta 5tubulin (uniprotkb:P99024), beta 2c tubulin (uniprotkb:P68372), alpha 1a tubulin (uniprotkb:P68369), b-Actin (uniprotkb:P60710), Tropomodulin-3 (uniprotkb:Q9JHJ0), Flightless-I (uniprotkb:Q9JJ28), FLAP1 (uniprotkb:Q3UZ39) and FLAP2 (uniprotkb:Q91WK0) by anti tag coimmunoprecipitation (MI:0007).
The effects of tax policy on financial markets: G3 evidence
Authors: Arin K. Peren , Mamun Abdullah , Purushothman Nanda 
Published: June 2008

AbstractWe investigate the effects of various tax policy innovations on stock market returns. By using a vector autoregressive model that controls for the mutual causality between fiscal policy and financial market performance, we test whether financial markets serve as a transmission mechanism for tax policy innovations. Our findings indicate that indirect taxes have a larger effect on market returns than do labor taxes. Further, corporate tax innovations do not have any statistically significant effect on stock returns. We consider that this finding is a result of a firm's ability to switch between equity financing and bond financing.
Role of ultrasound-guided fine needle aspiration in assessing the impalpable cervical node with increased18F-fluorodeoxyglucose uptake on positron emission tomography scanning: preliminary communication
Authors: Wang C-P , Lee C-Y , Lou P-J , Yen R-F , Hsiao J-K , Ko J-Y 
Published: June 2008

AbstractObjectives:18F-Fluorodeoxyglucose positron emission tomography can detect cervical metastases before they are palpable. However, false positive results are not uncommon. This paper reports the use of ultrasound-guided fine needle aspiration to determine the nature of impalpable cervical nodes that are positive on positron emission tomography scanning.Methods:Ultrasound-guided fine needle aspiration was performed in 10 cancer patients with suspicious cervical nodes revealed by positron emission tomography scan. Clinical data were retrospectively reviewed.Results:The underlying cancers included lung cancer (three patients), nasopharyngeal carcinoma (two), oesophageal cancer (two), buccal cancer (one), bladder cancer (one) and Langerhan's histiocytosis (one). The lymph nodes were located in the supraclavicular region in four patients, the level II region in four, the level IV region in one and the accessory chain in one. Cytological examination was positive for malignant cells in eight patients, all of whom received salvage treatment. Two of these patients died of distant metastases. Cytological examination revealed a benign or reactive lesion in two patients, who at the time of writing were alive and well, 19 and 36 months after examination.Conclusions:Ultrasound-guided fine needle aspiration is a minimally invasive procedure which enables cytological examination of suspicious cervical lymph nodes detected by positron emission tomography scanning, allowing further treatment to be planned.
Down syndrome: otolaryngological effects of rapid maxillary expansion
Authors: de Moura C Pinto , Andrade D , Cunha L M , Tavares M J , Cunha M J , Vaz P , Barros H , Pueschel S M , Pais Clemente M 
Published: June 2008

AbstractObjective:Phenotypical Down syndrome includes pharyngeal and maxillary hypoplasia and, frequently, constricted maxillary arch with nasal obstruction.Study design:This clinical trial assessed the effects of rapid maxillary expansion on ENT disorders in 24 children with Down syndrome randomly allocated to receive either rapid maxillary expansion or not. Each group received ENT and speech therapy assessments before expansion and after the device had been removed.Results:In the rapid maxillary expansion group, the yearly ENT infection rate was reduced when assessed after device removal (p < 0.01). The parents of rapid maxillary expansion children reported a reduction in respiratory obstruction symptoms. Audiological assessment revealed improvements in the rapid maxillary expansion group (p < 0.01). Cephalometry showed increased maxillary width in the rapid maxillary expansion group.Conclusions:Rapid maxillary expansion resulted in a reduction in hearing loss, yearly rate of ENT infections and parentally assessed symptoms of upper airway obstruction, compared with no treatment. These findings are probably related to expanded oronasal space, due to rapid maxillary expansion.
Analysis of oncological and functional failures following near-total laryngectomy
Authors: Thakar A , Bahadur S , Toran K C , Mohanti B K , Julka P K 
Published: June 2008

AbstractObjective:To improve case selection for near-total laryngectomy by identifying the causes of poor oncological and functional outcomes.Methods:Analysis of prospectively accrued data for 28 consecutive cases of near-total laryngectomy undertaken between 1996 and 2005 at a tertiary care centre. We analysed the impact of tumour extent and location, patient physiological status, and surgical technique on disease-free survival and on functional outcome.Results:Patients' average four-year Kaplan–Meier disease-free survival was 74 per cent (95 per cent confidence intervals, 46–89 per cent). Eighty-two per cent of patients had good to excellent functional outcomes. Pre-operative tumour extension to the ipsilateral arytenoid significantly compromised disease-free survival (patients with this development had a two-year survival of 40 per cent;p = 0.001). Internal communicating fistula formation (i.e. a fistula between the neopharynx and myomucosal shunt lumens) occurred in five of 28 cases and was uniformly associated with a poor functional outcome (i.e. lack of phonation with or without aspiration). Fistula formation was significantly more likely in cases with tumour involving the ipsilateral arytenoid and the ipsilateral subglottis.Conclusions:Significant disparity exists for the functional outcome of near-total laryngectomy in patients who develop post-surgical internal fistula, compared with those with uneventful healing. Tumour involvement of the ipsilateral arytenoid compromises the oncological and functional results. Tumour extension to the subglottis may compromise functional outcome. Near-total laryngectomy should be avoided in cases with ipsilateral arytenoid involvement, and undertaken with caution in cases with subglottic extension.
Electron microscopy study of peripheral nerves in the uvulae of snorers and obstructive sleep apnoea patients
Authors: Bassiouny A , Nasr S , Mashaly M , Ayad E , Qotb M , Atef A 
Published: June 2008

AbstractHypothesis:The pathophysiology of snoring and obstructive sleep apnoea is still unclear. Two theories are proposed. The first is the obstructive theory, which postulates palatopharyngeal muscle hypertrophy leading to airway narrowing; there is no neural role. The second is the neurogenic theory, which postulates neural degeneration due to vibratory stretch trauma, leading to muscle atrophy and collapse. As identification of nerve fibres in the uvula and palate is difficult and time-consuming, all previous studies aiming to differentiate between these two theories have been based on indirect observation of the muscles, rather than direct study of the nerves.Methods:We conducted a prospective study to directly observe and study nerve fibres in uvular specimens from 10 cases of obstructive sleep apnoea, compared with specimens from 10 cases of simple snoring, using transmission electron microscopy. Five autopsy cases served as controls.Results:Obstructive sleep apnoea was associated with definite degenerative changes in myelinated and unmyelinated nerve endings. These degenerative changes were present to a lesser degree and in a smaller proportion of cases of simple snoring.Conclusion:The events postulated by the neurogenic theory of obstructive sleep apnoea appear to play an important role in the pathophysiology of snoring and obstructive sleep apnoea.
Infection rates after tympanostomy tube insertion, comparing Aboriginal and non-Aboriginal children in the Northern Territory, Australia: a retrospective, comparative study
Authors: Jassar P , Sibtain A , Marco D , Jose J , Hunter G 
Published: June 2008

AbstractObjective:To determine if there is a difference in infection rates between Aboriginal and non-Aboriginal children, following tympanostomy and ventilation tube placement, in the Northern Territory, Australia.Materials and methods:A cohort of 213 patients aged zero to 10 years who had undergone tympanostomy and ventilation tube placement at the Royal Darwin Hospital between 1996 and 2004 were identified. Patients were divided into Aboriginal or non-Aboriginal groups, from their medical record. Factors such as age, sex, dwelling (remote or urban) and season were compared for each group, in order to ascertain if they contributed to infection rates. A retrospective analysis of cases was conducted for the two-year post-operative period.Results:There was no statistically significant difference in infection rates between the two groups (37 vs 35 per cent). There was no statistically significant difference when comparing the two groups for age, sex, season, or remote vs urban dwelling.Conclusion:Aboriginal children were not prone to more infections following tympanostomy tube placement when compared with non-Aboriginal children.
Maxillary haemangioma successfully resected by endoscopic approach
Authors: Kanazawa T , Inoue R , Ohta Y , Watanabe Y , Iino Y 
Published: June 2008

AbstractObjective:We report an extremely rare case of maxillary haemangioma.Method:Case report and review of the literature concerning haemangioma arising from the nasal cavity and paranasal sinuses.Results:Maxillary haemangioma is rare and sometimes requires wider resection than nasal haemangioma if a large tumour is found. We present a case of maxillary haemangioma in a 37-year-old Japanese woman, which was completely resected by pre-operative embolisation and endoscopic sinus surgery.Conclusion:Our findings suggest that if a large maxillary haemangioma is diagnosed pre-operatively, the treatment of choice is pre-operative embolisation followed by endoscopic sinus surgery, in order to avoid the surgical complications associated with wide resection.
Case of thyroid hemiagenesis and ectopic lingual thyroid presenting as goitre
Authors: Yang Y S , Hong K H 
Published: June 2008

AbstractObjective:We report an extremely rare case of thyroid hemiagenesis with ectopic lingual thyroid.Method:Case report and review of the world literature concerning thyroid hemiagenesis with ectopic lingual thyroid and heredity.Results:Ectopic thyroid is an uncommon embryological aberration characterised by the presence of thyroid tissue in a site other than its usual, pretracheal location. The lingual thyroid is the most common manifestation of benign ectopic thyroid tissue, but is still a rare clinical entity. Thyroid hemiagenesis is also a very rare abnormality, in which one thyroid lobe fails to develop. We report a case of left thyroid hemiagenesis and goitre in the right lobe in a 26-year-old woman with an ectopic lingual thyroid.Conclusion:To our knowledge, this is the first report in the world literature of thyroid hemiagenesis with ectopic lingual thyroid.
Paediatric tonsillectomy: parental experience and outcomes
Authors: Robb P J , Gowrinath K , Agyeman K , Joseph J 
Published: June 2008

AbstractObjective:To evaluate parental experience, satisfaction and outcomes following their child's tonsillectomy surgery.Design:Structured postal questionnaire sent to the parents or guardians of 77 sequential children undergoing elective day-case tonsillectomy.Subjects:Seventy-seven children with a mean age of 6.25 years (range three to 17 years) undergoing day-case tonsillectomy predominantly for recurrent acute tonsillitis, upper airway obstruction or a combination of these symptoms; 63.6 per cent of the parents or guardians of these children responded to the questionnaire.Results:There was overall satisfaction with the operation, and positive health outcomes.Conclusions:Despite the current public health agenda to limit access to routine high volume operations such as childhood tonsillectomy on economic grounds, the users of this service rated the outcomes and benefits of the procedure highly.
Anorexia nervosa trios: behavioral profiles of individuals with anorexia nervosa and their parents
Authors: Jacobs M. J. , Roesch S. , Wonderlich S. A. , Crosby R. , Thornton L. , Wilfley D. E. , Berrettini W. H. , Brandt H. , Crawford S. , Fichter M. M. , Halmi K. A. , Johnson C. , Kaplan A. S. , LaVia M. , Mitchell J. E. , Rotondo A. , Strober M. , Woodside D. B. , Kaye W. H. , Bulik C. M. 
Published: June 2008

BackgroundAnorexia nervosa (AN) is associated with behavioral traits that predate the onset of AN and persist after recovery. We identified patterns of behavioral traits in AN trios (proband plus two biological parents).MethodA total of 433 complete trios were collected in the Price Foundation Genetic Study of AN using standardized instruments for eating disorder (ED) symptoms, anxiety, perfectionism, and temperament. We used latent profile analysis and ANOVA to identify and validate patterns of behavioral traits.ResultsWe distinguished three classes with medium to large effect sizes by mothers' and probands' drive for thinness, body dissatisfaction, perfectionism, neuroticism, trait anxiety, and harm avoidance. Fathers did not differ significantly across classes. Classes were distinguished by degree of symptomatology rather than qualitative differences. Class 1 (~33%) comprised low symptom probands and mothers with scores in the healthy range. Class 2 (~43%) included probands with marked elevations in drive for thinness, body dissatisfaction, neuroticism, trait anxiety, and harm avoidance and mothers with mild anxious/perfectionistic traits. Class 3 (~24%) included probands and mothers with elevations on ED and anxious/perfectionistic traits. Mother–daughter symptom severity was related in classes 1 and 3 only. Trio profiles did not differ significantly by proband clinical status or subtype.ConclusionsA key finding is the importance of mother and daughter traits in the identification of temperament and personality patterns in families affected by AN. Mother–daughter pairs with severe ED and anxious/perfectionistic traits may represent a more homogeneous and familial variant of AN that could be of value in genetic studies.
A developmental twin study of symptoms of anxiety and depression: evidence for genetic innovation and attenuation
Authors: Kendler K. S. , Gardner C. O. , Lichtenstein P. 
Published: June 2008

BackgroundLittle is known about the pattern of genetic and environmental influences on symptoms of anxiety and depression (SxAnxDep) from childhood to early adulthood.MethodParental- and self-reported levels of SxAnxDep were assessed at ages 8–9, 13–14, 16–17 and 19–20 years in 2508 twins from the Swedish Twin Study of Child and Adolescent Development (TCHAD). Analysis conducted using the Mx program included SxAnxDep by parental and self-report.ResultsThe best-fit model revealed one genetic risk factor for SxAnxDep acting at ages 8–9, 13–14, 16–17 and 19–20, and new sets of genetic risk factors ‘coming on line’ in early adolescence, late adolescence and early adulthood. Together, these genetic factors were very strong influences on the levels of SxAnxDep reported in common by parents and twins with heritability estimates, correcting for rater- and time-specific effects, ranging from 72% to 89%. The first genetic factor, which accounted for 72% of the variance in SxAnxDep at ages 8–9, attenuated sharply in influence, accounting for only 12% of the variance by ages 19–20. No evidence was found for shared environmental influences. Although not statistically significant, the correlation between genetic risk factors for SxAnxDep in males and females declined with advancing age.ConclusionsGenetic effects on SxAnxDep are developmentally dynamic from middle childhood to young adulthood, demonstrating both genetic innovation and genetic attenuation. The attenuation might explain the low levels of continuity observed for anxiety and depressive disorders from childhood to adulthood. Differences in genetic risk factors for SxAnxDep in males and females may increase during development.
Précis ofNeuroconstructivism: How the Brain Constructs Cognition
Authors: Sirois Sylvain , Spratling Michael , Thomas Michael S. C. , Westermann Gert , Mareschal Denis , Johnson Mark H. 
Published: June 2008

AbstractNeuroconstructivism: How the Brain Constructs Cognitionproposes a unifying framework for the study of cognitive development that brings together (1) constructivism (which views development as the progressive elaboration of increasingly complex structures), (2) cognitive neuroscience (which aims to understand the neural mechanisms underlying behavior), and (3) computational modeling (which proposes formal and explicit specifications of information processing). The guiding principle of our approach iscontext dependence, within and (in contrast to Marr [1982]) between levels of organization. We propose that three mechanisms guide the emergence of representations: competition, cooperation, and chronotopy; which themselves allow for two central processes: proactivity and progressive specialization. We suggest that the main outcome of development is partial representations, distributed across distinct functional circuits. This framework is derived by examining development at the level of single neurons, brain systems, and whole organisms. We use the termsencellment,embrainment, andembodimentto describe the higher-level contextual influences that act at each of these levels of organization. To illustrate these mechanisms in operation we provide case studies in early visual perception, infant habituation, phonological development, and object representations in infancy. Three further case studies are concerned with interactions between levels of explanation: social development, atypical development and within that, developmental dyslexia. We conclude that cognitive development arises from a dynamic, contextual change in embodied neural structures leading to partial representations across multiple brain regions and timescales, in response to proactively specified physical and social environment.
Are interactive specialization and massive redeployment compatible?
Authors: Anderson Michael L. 
Published: June 2008

AbstractI offer a simple method for further investigating the Interactive Specialization framework, and some data that may or may not be compatible with the approach, depending on the precise meaning of “specialization.” Findings from my lab indicate that, while networks of brain areas cooperate in specialized ways to support cognitive functions, individual brain areas participate in many such networks, in different cognitive domains.
Neuroconstructivism: Evidence for later maturation of prefrontally mediated executive functioning
Authors: Foster Jonathan , van Eekelen Anke , Mattes Eugen 
Published: June 2008

AbstractThe authors of this commentary concur with the viewpoint presented by Mareschal et al. (2007a; 2007b) concerning the relevance of neurological data when theorizing about cognitive development. However, we argue here that Mareschal et al. fail to consider adequately the relevance of reorganizational brain events occurring through adolescence and early adulthood, especially regarding the prefrontal cortex and the ontogeny of executive functioning. In addition, evidence from the lifespan neurodevelopmental literature indicates that increased activity of neural networks may signify less efficient processing. This observation is of potential relevance when considering the neurological changes associated with cognitive development during childhood and adolescence.
Beyond mechanism and constructivism
Authors: Kotchoubey Boris 
Published: June 2008

AbstractNeuroconstructivism is a hybrid of two incompatible philosophical traditions: a radical idealism insisting upon the free activity of the Subject; and a radical materialistic anthropomorphism, which ascribes inherent properties of humans (e.g., the ability to construct) to nonhuman objects or body parts (e.g., the brain). The two traditions can be combined only by obscuring or confusing the basic notions.