bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase II Study of Osimertinib in Patients With Epidermal Growth Factor Receptor Mutations: Results From the NCI-MATCH ECOG-ACRIN (EAY131) Trial Subprotocol E
Authors: Chen Monica F. , Song Zihe , Yu Helena A. , Sequist Lecia V. , Lovly Christine M. , Mitchell Edith P. , Moscow Jeffrey A. , Gray Robert J. , Wang Victoria , McShane Lisa M. , Rubinstein Larry V. , Patton David R. , Williams P. Mickey , Hamilton Stanley R. , Umemura Yoshie , Tricoli James V. , Conley Barbara A. , Arteaga Carlos L. , Harris Lyndsay N. , O'Dwyer Peter J. , Chen Alice P. , Flaherty Keith T. 
Published: March 2024

PURPOSE The National Cancer Institute Molecular Analysis for Therapy Choice trial is a signal-finding genomically driven platform trial that assigns patients with any advanced refractory solid tumor, lymphoma, or myeloma to targeted therapies on the basis of next-generation sequencing results. Subprotocol E evaluated osimertinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, in patients with EGFR mutations. METHODS Eligible patients had EGFR mutations (T790M or rare activating) and received osimertinib 80 mg once daily. Patients with lung cancer with EGFR T790M were excluded. The primary end point was objective response rate (ORR), and the secondary end points were 6-month progression-free survival (PFS), overall survival, and toxicity. RESULTS A total of 19 patients were enrolled: 17 were evaluable for toxicity and 13 for efficacy. The median age of the 13 included in the efficacy analysis was 63 years, 62% had Eastern Cooperative Oncology Group performance status 1, and 31% received >three previous systemic therapies. The most common tumor type was brain cancers (54%). The ORR was 15.4% (n = 2 of 13; 90% CI, 2.8 to 41.0) and 6-month PFS was 16.7% (90% CI, 0 to 34.4). The two confirmed RECIST responses were observed in a patient with neuroendocrine carcinoma not otherwise specified ( EGFR exon 20 S768T and exon 18 G719C mutation) and a patient with low-grade epithelial carcinoma of the paranasal sinus ( EGFR D770_N771insSVD). The most common (>20%) treatment-related adverse events were diarrhea, thrombocytopenia, and maculopapular rash. CONCLUSION In this pretreated cohort, osimertinib did not meet the prespecified end point threshold for efficacy, but responses were seen in a neuroendocrine carcinoma with an EGFR exon 20 S768T and exon 18 G719C mutation and an epithelial carcinoma with an EGFR D770_N771insSVD mutation. Osimertinib was well tolerated and had a safety profile consistent with previous studies.
Débats et propositions préliminaires sur la graphie monégasque d’après un tapuscrit inédit de Lazare Sauvaigo (1926–1927)
Authors: Lusito Stefano 
Published: March 2024

By virtue of its status as a national language recognised by the princely institutions, Monegasque is the only Ligurian variety to have an officially regulated spelling system. The current writing norms, sanctioned by the Commission pour la langue monégasque, represent in essence the standardisation of the spelling choices introduced and developed in the last century by Louis Notari (1879–1961), the originator of literature in this language.
This paper aims to illustrate the first proposal for the systematisation of Monegasque spelling, formulated between 1926 and 1927 within the Comité des traditions locales (ancestor of the current Comité national des traditions monégasques), an association established a few years earlier with the aim of protecting and safeguarding the linguistic and folkloric heritage of the Principality of Monaco. The proposal, while fairly naïve in terms of its approach and content, is a striking testimony to the first steps towards the linguistic analysis and representation of a variety which, until then, had not yet been codified and had known practically no written usage.
Diagnostic accuracy of serological rk-39 test for visceral Leishmaniasis: Systematic review and meta-analysis
Authors: Getnet Mihret , Minaye Dejen Addisu , Abebaw Dessie , Fentahun Getachew Gedefaw , Birhanu Emebet 
Published: March 2024

Background
Visceral leishmaniasis (VL), or kala-azar, is a vector-borne tropical disease caused by a group of intracellular hemoflagellate protozoa belonging to the family of Trypanosomatide and the genus Leishmania. The disease is distributed around the world and transmitted via the bite of infected female Phlebotomine sandflies, and there is variation in the diagnostic accuracy. Therefore, this systematic review and meta-analysis aimed to determine the pooled global sensitivity and specificity of the rk-39 test and to evaluate if there is a difference between the different parts of the world.

Methods
A systematic review and meta-analysis have been conducted on the diagnostic accuracy of dermoscopy. After setting eligibility criteria, literature was searched in four databases and one searching engine. Articles were screened, critically appraised, and extracted independently by two reviewers, and any disagreements were resolved with the involvement of a third person. The quality of the included studies had been assessed by the Quality Assessment of Diagnostic Accuracy Studies (QUADAS 2) tool. Pooled sensitivity and specificity were determined by bivariate random effect analysis. Heterogeneity was assessed by Higgins’s I2, and when it was present, mitigation was conducted by using sensitivity analysis.

Result
A total of 409 studies were identified, and finally 18 articles were eligible for the review with a total sample size of 5, 253. The bivariate random effect meta-analysis of the 7 diagnostic accuracy studies showed a pooled sensitivity of 0.89 (0.76–0.95) and specificity of 0.86 (0.72–0.94). The +LR was 6.32 (95% CI: 2.85–14.02), the–LR was 0.13 (95% CI: 0.06–0.30), and the diagnostic odds ratio (DOR) was 47.8 (95% CI: 11.3–203.2). Abdel-Latif (2018) was both an outlier and influential for sensitivity, and Walter (2011) was both an outlier and influential for specificity, and removing them from sensitivity and specificity, respectively, was beneficial for reducing the heterogeneity.

Conclusion
Rk-39 is found to have highly accurate measures in the diagnosis of visceral leishmaniasis. Both sensitivity and specificity were found to be highly accurate in the diagnosis of leishmaniasis, with a pooled sensitivity of 0.91 (0.88–0.93) and a pooled specificity of 0.89 (0.85–0.91).

Ethical consideration
As we will use secondary data for the systematic review and meta-analysis, ethical concerns are not necessary.
A comparison of Bayesian and frequentist approaches to incorporating clinical and biological information for the prediction of response to standardized pediatric colitis therapy
Authors: Wang Zhu , Nie Jia , Song Xing , Denson Lee A. , Hyams Jeffrey S. 
Published: March 2024

Background
The prospective cohort study PROTECT is the largest study in pediatric ulcerative colitis (UC) with standardized treatments, providing valuable data for predicting clinical outcomes. PROTECT and previous studies have identified characteristics associated with clinical outcomes. In this study, we aimed to compare predictive modeling between Bayesian analysis including machine learning and frequentist analysis.

Methods
The key outcomes for this analysis were week 4, 12 and 52 corticosteroid (CS)-free remission following standardized treatment from diagnosis. We developed predictive modeling with multivariable Bayesian logistic regression (BLR), Bayesian additive regression trees (BART) and frequentist logistic regression (FLR). The effect estimate of each risk factor was estimated and compared between the BLR and FLR models. The predictive performance of the models was assessed including area under curve (AUC) of the receiver operating characteristic (ROC) curve. Ten-fold cross-validation was performed for internal validation of the models. The estimation contained 95% credible (or confidence) interval (CI).

Results
The statistically significant associations between the risk factors and early or late outcomes were consistent between all BLR and FLR models. The model performance was similar while BLR and BART models had narrower credible intervals of AUCs. To predict week 4 CS-free remission, the BLR model had AUC of 0.69 (95% CI 0.67–0.70), the BART model had AUC of 0.70 (0.67–0.72), and the FLR had AUC of 0.70 (0.65–0.76). To predict week 12 CS-free remission, the BLR model had AUC of 0.78 (0.77–0.79), the BART model had AUC of 0.78 (0.77–0.79), and the FLR model had AUC of 0.79 (0.74–0.83). To predict week 52 CS-free remission, the BLR model had AUC of 0.69 (0.68–0.70), the BART model had AUC of 0.69 (0.67–0.70), and the FLR model had AUC of 0.69 (0.64–0.74). The BART model identified nonlinear associations.

Conclusions
BLR and BART models had intuitive interpretation on interval estimation, better precision in estimating the AUC and can be alternatives for predicting clinical outcomes in pediatric patients with UC. BART model can estimate nonlinear nonparametric association.
Language-based EMA assessments help understand problematic alcohol consumption
Authors: Nilsson August Håkan , Schwartz Hansen Andrew , Rosenthal Richard N. , McKay James R. , Vu Huy , Cho Young-Min , Mahwish Syeda , Ganesan Adithya V. , Ungar Lyle 
Published: March 2024

BackgroundUnhealthy alcohol consumption is a severe public health problem. But low to moderate alcohol consumption is associated with high subjective well-being, possibly because alcohol is commonly consumed socially together with friends, who often are important for subjective well-being. Disentangling the health and social complexities of alcohol behavior has been difficult using traditional rating scales with cross-section designs. We aim to better understand these complexities by examining individuals’ everyday affective subjective well-being language, in addition to rating scales, and via both between- and within-person designs across multiple weeks.MethodWe used daily language and ecological momentary assessment on 908 US restaurant workers (12692 days) over two-week intervals. Participants were asked up to three times a day to “describe your current feelings”, rate their emotions, and report their alcohol behavior in the past 24 hours, including if they were drinking alone or with others.ResultsBoth between and within individuals, language-based subjective well-being predicted alcohol behavior more accurately than corresponding rating scales. Individuals self-reported being happier on days when drinking more, with language characteristic of these days predominantly describing socializing with friends. Between individuals (over several weeks), subjective well-being correlated much more negatively with drinking alone (r= -.29) than it did with total drinking (r= -.10). Aligned with this, people who drank more alone generally described their feelings assad,stressedandanxiousand drinking alone days related tonervousandannoyedlanguage as well as a lower reported subjective well-being.ConclusionsIndividuals’ daily subjective well-being, as measured via language, in part, explained the social aspects of alcohol drinking. Further, being alone explained this relationship, such that drinking alone was associated with lower subjective well-being.
Observaciones sobre IGUR III 1427
Authors: Muñoz Martínez Sandra 
Published: March 2024

En este trabajo se presenta una nueva edición del poema epigráfico bilingüe (griego-latín) que Moretti catalogó como IGUR III 1427, encontrado en Roma y ya en estado fragmentario. Las lecturas propuestas, tal como se indicará a lo largo del documento, son hipotéticas y no tienen intención de ser absolutas, pues el texto conservado no supone más de una tercera parte de la inscripción original. Asimismo, se comentarán algunos aspectos relativos al posible origen del difunto, cuyo nombre no está atestiguado en el epígrafe que ha perdurado, con base en la información que se puede desprender de esta pieza en su totalidad.
Introducción
Authors: Santamaría Álvarez Marco Antonio 
Published: March 2024

Introducción al dossier que incluye varios de los trabajos presentado en el congreso «Transformaciones de los mitos griegos: parodia y racionalización», celebrado en la Facultad de Letras/Letren Fakultatea de la Universidad del País Vasco (UPV/EHU) en Vitoria-Gasteiz el 6 y 7 de julio de 2022.
Teaching Customer Service Principles Using the Massive Open Online Course (Moocs) Platform
Authors: Yunus Noor Azlina Mohamed , Ibrahim Norzawani , Zakaria Ibhrahim , Zainuddin Ahmad Zuhairi , Salleh Mohammad Zaim Mohd , Abd Rahim Nur Najjah 
Published: March 2024

This study reviewed the effects of a developing MOOC platform for Customer Service Principles course in higher education. Essentially, the Customer Service Principles course is designed to give knowledge and exposure about the fundamental of customer service and discover how to deliver customer service efficiently across various sectors. The development of MOOC platform is believed to be a role of an interactive learning method to attract and motivates students to clearly understand and to apply this course effectively. The originality of this study is its review the MOOC platform as an interactive learning method specifically for Customer Service Principles course, something that has been unobserved by previous scholars. This study will contribute to the body of knowledge on the effect of MOOC platform and to improve the learning activities for higher education institution.
The Effect of Inflation and Interest Rate on Consumer Spending: Empirical Evidence from Malaysia
Authors: Nizam Nurin Sabrina Khairul , Safian Sharulshahida Shakrein , Jamaludin Salwaty , Osman Adibah Alawiah 
Published: March 2024

This study seeks to determine the exact impact of inflation, interest rate and disposable income on consumer spending in Malaysia. Although there have been few studies which explored the issue of inflation, interest rate, disposable income and consumer spending, their method, time scope and geographical location had been different. This study aims to examine the relationship of inflation (CPI), interest rate, disposable income (GDP per capita) with consumer spending in Malaysia using annual time series data from the period 1980 to 2022 and employing Ordinary Least Square (OLS) and Granger Causality to test causality relationship amongst variables. The result revealed that there is a significant negative relationship between interest rate and consumer spending. However, inflation rate has an insignificant positive effect with consumer spending. Disposable income (GDP) shows a significant positive relationship on consumer spending. In addition, the findings supported Keynesian Absolute Income Hypothesis which stated that consumption positively correlates with disposable income. The study recommends the employers of labour should make an effort to periodically raise workers' wages to reflect shifts in the macroeconomic and microeconomic conditions impacting the country. Only when wages are raised in line with the nation's economic conditions will consumers be able to improve their consumption expenditures through an increase in disposable income. Policies that lower taxes should also be developed to increase consumers' disposable income.
Practitioners’ Perspectives on B40 Takaful Protection
Authors: Senawi Azhan Rashid , Kamarudin Mohd Faizal , Ariffin Azitadoly Mohd , Mokhtar Mohammad Zulfakhairi , Putriani Diyah 
Published: March 2024

Takaful is a form of insurance that adheres to shariah principles and has been established in Malaysia since 1984. With takaful, Muslims are protected from any ambiguous activities or transactions that are not aligned with shariah. However, participation in takaful reveals that only affluent individuals have the means to protect themselves against risks, whereas the impoverished, particularly the B40, cannot do so. The B40 refers to a specific socio-economic group in a given population in the lower-income category with an annual income below RM 4,850. No other takaful and insurance business has demonstrated a willingness to provide a system specifically designed to safeguard the B40, as observed. They have been excluded from any form of protection. Consequently, the question arose: do they possess a favorable outlook for Takaful? Hence, the SWOT analysis was employed to assess the competitiveness of the B40 market. Eleven takaful operator agency participants were randomly selected for semi-structured interviews. All the answers will be tabulated from these interviews according to the SWOT categories. This study aims to analyze the B40 market for takaful goods, identify the obstacles takaful operators face, and propose ways to increase the takaful penetration rate, focusing on the family takaful product.
Investigating the Correlation Among Social Media Marketing, Electronic Word-Of-Mouth, Celebrity Endorsements, and Consumer’s Purchase Intention of Cosmetic Products
Authors: Halid Nur Farrah Mohammad , Tajuddin Nur Akmal Ahmad , Abas Zahidatun Najah Md , Yusof Yuslina Liza Mohd 
Published: March 2024

Instagram is one of the most popular and fastest-growing social commerce platforms among Gen Y, as it allows users to browse online shops by using visual interface on a mobile device. They are also used to shopping online using this platform. Most cosmetic products company adapting social media marketing by promoting products using social commerce such as and Instagram. Thus, the purpose of this study is to empirically investigate the relationship between social media marketing, electronic word of mouth, celebrity endorsement, and purchase intention on social commerce of cosmetic products in Malaysia. The unit of analysis is individual that was more likely to buy when they were exposed to social media marketing, electronic word-of-mouth, and celebrity endorsement on social commerce which was Instagram. The descriptive statistics analysis was applied to describe the different characteristics of the respondents. The study's outcomes demonstrated a noteworthy and affirmative connection between consumers' purchase intention and social media marketing, electronic word of mouth, along with celebrity endorsement. This research centers around three pivotal variables: social media marketing, electronic word of mouth, and celebrity endorsement. The conclusions drawn from this study can serve as valuable pointers for enhancing the realm of social commerce among cosmetic product marketers. This study holds significance in its exploration of the determinants impacting consumers' purchase intent for cosmetic products. Furthermore, it furnishes cosmetic product marketers with a set of four strategic recommendations to enhance their social commerce endeavor. The recommendations encompass the utilization of customer testimonials/reviews sharing, collaboration with celebrities or influencers of diverse backgrounds, staying abreast of developments in social media, augmented reality (AR), and artificial intelligence (AI).
Innovation in the Malaysian Traditional Food Industry: A Conceptual Paper
Authors: Abdullah Khairunnisa Mohamad , Putit Lennora , Yulia Cica 
Published: March 2024

Nowadays, Malaysia ‘s sub-sector of the agricultural commodity industry, particularly the innovative and convenient traditional food products, is expanding in tandem with increasing urbanisation and women workforce, reduction in household size and current lifestyle changes respectively. There are a variety of products in the Malaysian market that have been created by incorporating innovation into traditional Malaysian foods. As such, this situation has led to intense competition and oversupply of products in the market, and it requires food companies to develop critical strategies for introducing innovations in traditional foods so as to be sustainable and more competitive. The aim of this paper is two-fold: firstly, to provide an overview of innovation development in the Malaysian traditional food industry. This paper reveals that, studies on innovation in Malaysian traditional food industry remains under-researched and scarce until to date. The present study also reveals that a clear understanding of consumer perceptions, needs, and preferences, as well as a product's quality attributes, is critical when making even minor changes to traditional foods, thus leading to successful introduction of innovation in traditional foods. Besides that, sustaining consumer continuance behaviour beyond initial purchase and consumption is crucial for innovative food product success and sustained market.
The Acceptance of Augmented Reality's Role in Elevating Customer Attitude within Malaysia's Local Fashion Merchandising
Authors: Ibrahim Nadhrathul Ain , Chen Tan Yi , Ahmad Nur Hidayah , Antara Purnomo M. , Beta Mayang Delima Mohd , Musa Rosidah 
Published: March 2024

The adoption of augmented reality has recently developed as a popular approach for conducting digital business via virtual try-ons, virtual fitting rooms, online shopping apps, and digital wardrobes. Retailers are switching from traditional online shopping to a more interactive strategy, drawn by the usefulness of augmented reality. This research intends to investigate the impact of attributes such as interaction, vividness, and novelty on perceived usefulness and perceived ease of use, impacting customer attitudes towards using augmented reality in online fashion buying. Using the Technology Acceptance Model (TAM) framework, the study demonstrates that all of these features have a significant effect on perceived usefulness and perceived ease of use, influencing buyers to accept augmented reality on virtual try-ons, virtual fitting rooms, online shopping apps and digital wardrobe in their online fashion shopping experiences.
Aristotle on Non-substantial Particulars, Fundamentality, and Change
Authors: Shatalov Keren Wilson 
Published: March 2024

Abstract
There is a debate about whether particular properties are for Aristotle non-recurrent and trope-like individuals or recurrent universals. I argue that Physics I.7 provides evidence that he took non-substantial particulars to be neither; they are instead non-recurrent modes. Physics I.7 also helps show why this matters. Particular properties must be individual modes in order for Aristotle to preserve three key philosophical commitments: that objects of ordinary experience are primary substances, that primary substances undergo genuine change, and that primary substances are ontologically fundamental.
Application of the integrated airway humidification device enhances the humidification effect of the rabbit tracheotomy model
Authors: Sheng Honglan , Ni Jie , Zhao Feng , Tian Mi , Zhao Yuhang , Dai Longmei , Li Ting , Xue Yun , Song Zongze , Yu Qiong 
Published: March 2024

Abstract
Long-term mechanical ventilation after tracheotomy is a common treatment in intensive care unit patients. This study investigated the differences among the effects of different wetting states on the airway, lung, and serum inflammatory factors. New Zealand rabbits (n = 36) were selected to construct tracheotomy models and then divided into four groups: Model, Mask, YTH, and Sham groups. Lung tissue dry/wet ratio was used to evaluate the humidification effect; cytokines, including tumor necrosis factor-α, interleukin (IL)-6, IL-8, and IL-10, were used to evaluate the inflammatory response; hematoxylin and eosin staining was used to evaluate the histopathology. Post hoc analysis based on the Dunnett t-test was applied. A self-developed integrated wetting device could increase the utilization of wetting solution, enhance the effect of wetting to protect tissue integrity, and suppress airway inflammation, reducing the expression of pro-inflammatory factors while promoting the expression of anti-inflammatory factor IL-10 to inhibit the inflammatory response, compared to other methods. The integrated humidification device provided a new method for clinical nursing practice, improving clinical efficiency and reducing nursing workload. Further clinical trials are required to test its effectiveness and safety in the clinic.