bluuebunny/crossref_metadata_2025_split huggingface dataset:
PREDIKSI KEBANGKRUTAN MENGGUNAKAN METODE Z-SCORE DAN PENGARUHNYA TERHADAP HARGA SAHAM PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Ubaidillah Roykhan  
Published: March 2024

Perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia tentunya tidak bisa lepas dari dampak krisis keuangan global pada tahun 2008. Stabilitas sistem keuangan perusahaan manufaktur yang terdaftar pada Bursa Efek Indonesia sangat rentan terhadap krisis keuangan global, hal ini apabila tidak segera diantisipasi oleh manajemen akan mengakibatkan potensi kebangkrutan yang tinggi pada perusahaan terkait. Penelitian ini bertujuan untuk menguji dan mengatahui bagaimana metode Z-Score Altman yang dikembangkan pada tahun 1984 mampu memprediksi kebangkrutan yang terjadi pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia, serta mengetahui dan menguji pengaruh prediksi kebangkrutan tersebut terhadap harga saham pertusahaan terkait. Z-Score yang diterapkan dalam penelitian ini berhasil menggolongkan sampel perusahaan yang terdaftar di Bursa Efek Indonesia pada kategori tidak bangkrut, daerah rawan, dan tidak bangkrut. Uji hipotesis untuk mengetahui pengaruh terhadap harga saham dalam penelitian ini menggunakan uji t, dimana hasil uji tersebut menyatakan bahwa ada pengaruh antara prediksi kebangkrutan menggunakan Z-Score terhadap harga saham perusahaan yang terdaftar di Bursa Efek Indonesia.
PENGARUH TINGKAT SUKU BUNGA KREDIT DAN CAPITAL ADEQUACY RATIO TERHADAP PROFITABILITAS ( RETURN ON ASSET) (Studi Pada Perusahaan Perbankan Yang Terdaftar di Bursa Efek Indonesia Periode 2011-2013)
Authors: MEDHA AYOE P. TYA  , Wiwiek Kusumaning Asmoro  
Published: March 2024

The purpose of this research was to determine the effect of financial ratio analysis of the company's profitability in banking. This research is a hypothesis test, which examines the effect of variables that can affect profitability.
This research is a quantitative research using secondary data collection techniques, to conduct library research and documentation. The secondary data used in this research were obtained from the official website of the Indonesia Stock Exchange and Bank Indonesia's website. Companies sampled in this research amounted to 15, year of research period from 2011 to 2013, the sampling technique used was purposive sampling. The data used are annual financial statements. Data analysis techniques in this research using multiple regression, hypothesis testing method used is the coefficient of determination, simultaneous regression coefficient test, and test the partial regression coefficients.
The results of this research indicate that all information simultaneously Credit Interest Rateand the Capital Adequacy Ratio (CAR), effect on profitability. Partially loan interest rate has no effect on profitability, while the Capital Adequacy Ratio (CAR) that affect profitability.
PENGARUH LABA KREDIT DAN NON PERFORMING LOAN TERHADAP RETURN ON ASSETS (Studi Empiris Pada Perusahaan Pembiayaan Yang Terdaftar Di Bursa Efek Indonesia)
Authors: MUHAMMAD RAHARDYAN  , Dion Yanuarmawan  
Published: March 2024

The purpose of this study was to examine effect of credit profit and non performing loans on profitability as measured by return on assets. Research object is a Registered Finance Company in Indonesia Stock Exchange from 2008 - 2012 This study used a descriptive quantitative method that consists of three variables: Income Loans and Non-Performing Loans as independent variables and ROA as the dependent variable. The type of data used is quantitative data and data sources used are secondary data. This data collection technique is the technique of documentation and literature study. Methods of data analysis used in this study is multiple regression analysis and tested by t-test.The test results showed that the levels of credit has a significant effect on profitability.
These results can be seen in the R Square of 0.522, which means the relationship between the profitability of credit has a very strong relationship. The results of this study confirmed the hypothesis testing results through the t test showed a significance level of 0.000 and credit profit 0,046 NPL, both are below 0.05, which means the level of income and credit NPL significant effect on profitability (ROA).
PENGARUH DENDA TERHADAP TINGKAT NON PERFORMING LOAN (STUDI KASUS PADA PT. BRI (PERSERO),Tbk CABANG KEDIRI TAHUN 2012-2014)
Authors: Sherly Ayu Aprylya  
Published: March 2024

This research aims to know the influence of fines against the level of NPL. Fines in this study was divided into two fine daily and monthly fines as measured by nominal. NPL at this research is measured by a ratio. This research is the research hypothesis tests that test the influence of the variables that can affect the level of NPL.
This study uses secondary data collection techniques, by conducting studies, librarianship and documentation. Secondary data used in the study was obtained from the financial statements of PT BRI (Persero), Tbk branch of Kediri in 2012-2014. The sample in this research is one hundred clients with credit research period from 2012 to 2014, with a sampling technique used was purposive sampling. Technique of data analysis in this study using multiple linear regression, hypothesis testing method used is test the coefficient of determination , the keberartian test model, and the significance of the individual parameters.
Determination of coefficient of test results was 33.5%, which means that daily fines and fines affecting monthly NPL amounting to 33.5% and the rest IE 66,5% explained by causes other than the independent variable used in this research. The results of this research show that simultaneously daily fines and fines significantly influential monthly against the level of NPL. The influential daily fines partially significantly to the level of NPL, and significantly influential monthly fines against the level of NPL.
ANALISIS TINGKAT KEMANDIRIAN, EFEKTIFITAS DAN EFISIENSI TERHADAP PENDAPATAN ASLI DAERAH (PAD) PADA DINAS PENDAPATAN PENGELOLAAN KEUANGAN DAN ASET DAERAH (DPPKAD) DI PEMERINTAH KABUPATEN NGANJUK TAHUN 2011-2014
Authors: Uyik Retnaning Sayekti  
Published: March 2024

Penelitian ini merupakan studi kasus untuk menganalisis tingkat kemandiriaan, efektifitas dan efisiensi terhadap Pendapatan Asli Daerah (PAD) pada Dinas Pendapatan Pengelolaan Keuangan dan Aset Daerah Tahun 2011-2014. Variabel yang digunakan dalam penelitian ini adalah variabel dependen yaitu Dinas Pendapatan Pengelolaan Keuangan dan Aset Daerah sedangkan variabel independennya yaitu Tingkat Kemandirian, Efektifitas dan Efisiensi Pendapatan Asli Daerah (PAD)
Jenis data yang digunakan adalah data Primer dengan menggunakan data laporan keuangan Tahun 2011-2014. Sampel yang digunakan dalam penelitian ini adalah Laporan Keuangan Dinas Pendapatan Pengelolaan Keuangan dan Aset Daerah dan populasi yang digunakan adalah seluruh Dinas Pendapatan Pengelolaan Keuangan dan Aset Daerah.
Dari hasil yang dilakukan diperoleh kesimpulan bahwa Tingkat Kemandirian, efektifitas dan efisiensi dari tahun ketahun menunjukkan tingkat yang fluktuatif, sehingga berbeda darii tahun ketahun.
Case Report: Multiple types of arrhythmias in a late-confirmed Danon disease
Authors: Wang Nan , Cao Yu , Wang Jie , Zhang Qing 
Published: March 2024

IntroductionDanon disease is an X-linked disorder caused by pathogenic variants in lysosome-associated membrane protein 2 (LAMP2) gene, typically characterized by the triad of hypertrophic cardiomyopathy, myopathy, and intellectual disability. However, many patients may not present the typical presentation, especially in the early stage. Electrocardiogram (ECG) abnormalities can be found in almost all patients, with Wolff–Parkinson–White (WPW) syndrome being the most common. We reported the case of a 51-year-old woman who experienced multiple types of arrhythmias over three decades and was diagnosed with Danon disease late by genetic testing.Case summaryA 51-year-old woman with a 36-year history of intermittent palpitations was admitted due to hemodynamically stable ventricular tachycardia (VT). Her past medical history revealed multiple arrhythmias and ECG abnormalities in her 30s and 40s, including WPW syndrome with paroxysmal supraventricular tachycardia, paroxysmal atrial flutter, atrial fibrillation, ventricular tachycardia, and complete left bundle branch block. She denied any family history of cardiovascular disease or sudden death. Upon arrival, her vital signs were unremarkable. Cardiovascular magnetic resonance (CMR) imaging revealed left ventricular enlargement and late gadolinium enhancement (LGE) in the anterior, inferior, and lateral walls. Subsequent, whole-exome sequencing (WES) gene testing revealed a pathogenic heterozygous variant in LAMP2 gene (c.696T&gt;A; p.Cys232Ter), which confirmed the diagnosis of Danon disease.ConclusionGenetic testing should be considered in patients who display multiple arrhythmias with LV structural abnormalities of unknown etiology for a possible Danon disease.
Exploring deep learning radiomics for classifying osteoporotic vertebral fractures in X-ray images
Authors: Zhang Jun , Xia Liang , Liu Jiayi , Niu Xiaoying , Tang Jun , Xia Jianguo , Liu Yongkang , Zhang Weixiao , Liang Zhipeng , Zhang Xueli , Tang Guangyu , Zhang Lin 
Published: March 2024

PurposeTo develop and validate a deep learning radiomics (DLR) model that uses X-ray images to predict the classification of osteoporotic vertebral fractures (OVFs).Material and methodsThe study encompassed a cohort of 942 patients, involving examinations of 1076 vertebrae through X-ray, CT, and MRI across three distinct hospitals. The OVFs were categorized as class 0, 1, or 2 based on the Assessment System of Thoracolumbar Osteoporotic Fracture. The dataset was divided randomly into four distinct subsets: a training set comprising 712 samples, an internal validation set with 178 samples, an external validation set containing 111 samples, and a prospective validation set consisting of 75 samples. The ResNet-50 architectural model was used to implement deep transfer learning (DTL), undergoing -pre-training separately on the RadImageNet and ImageNet datasets. Features from DTL and radiomics were extracted and integrated using X-ray images. The optimal fusion feature model was identified through least absolute shrinkage and selection operator logistic regression. Evaluation of the predictive capabilities for OVFs classification involved eight machine learning models, assessed through receiver operating characteristic curves employing the “One-vs-Rest” strategy. The Delong test was applied to compare the predictive performance of the superior RadImageNet model against the ImageNet model.ResultsFollowing pre-training separately on RadImageNet and ImageNet datasets, feature selection and fusion yielded 17 and 12 fusion features, respectively. Logistic regression emerged as the optimal machine learning algorithm for both DLR models. Across the training set, internal validation set, external validation set, and prospective validation set, the macro-average Area Under the Curve (AUC) based on the RadImageNet dataset surpassed those based on the ImageNet dataset, with statistically significant differences observed (P&lt;0.05). Utilizing the binary “One-vs-Rest” strategy, the model based on the RadImageNet dataset demonstrated superior efficacy in predicting Class 0, achieving an AUC of 0.969 and accuracy of 0.863. Predicting Class 1 yielded an AUC of 0.945 and accuracy of 0.875, while for Class 2, the AUC and accuracy were 0.809 and 0.692, respectively.ConclusionThe DLR model, based on the RadImageNet dataset, outperformed the ImageNet model in predicting the classification of OVFs, with generalizability confirmed in the prospective validation set.
Salicin alleviates periodontitis via Tas2r143/gustducin signaling in fibroblasts
Authors: Zhang Zhiying , Zhou Zhiyan , Liu Jiaxin , Zheng Liwei , Peng Xian , Zhao Lei , Zheng Xin , Xu Xin 
Published: March 2024

IntroductionCells expressing taste signaling elements in non-gustatory tissues have been described as solitary chemosensory cells (SCCs) or tuft cells. These “taste-like” cells play a critical role in the maintenance of tissue homeostasis. Although the expression of SCC markers and taste signaling constituents has been identified in mouse gingivae, their role in periodontal homeostasis is still unclear. MethodsPublic RNA sequencing datasets were re-analyzed and further validated with RT-PCR/qRT-PCR and immunofluorescent staining to explore the expression of TAS2Rs and downstream signaling constituents in mouse gingival fibroblasts (MGFs). The specific action of salicin on MGFs via Tas2r143 was validated with RNA silence, heterologous expression of taste receptor/Gα-gustducin and calcium imaging. The anti-inflammatory effects of salicin against LPS-induced MGFs were investigated in cell cultures, and were further validated with a ligature-induced periodontitis mouse model using Ga-gustducin-null (Gnat3−/−) mice. ResultsThe expression of Tas2r143, Gnat3, Plcb2, and TrpM5 was detected in MGFs. Moreover, salicin could activate Tas2r143, elicited taste signaling and thus inhibited LPS-induced chemokines expression (CXCL1, CXCL2, and CXCL5) in MGFs. Consistently, salicin-treatment inhibited periodontal bone loss, inflammatory/chemotactic factors expression, and neutrophil infiltration in periodontitis mice, while these effects were abolished in Gnat3−/− mice. DiscussionGingival fibroblasts play a critical role in the maintenance of periodontal homeostasis via “SCC-like” activity. Salicin can activate Tas2r143-mediated bitter taste signaling and thus alleviate periodontitis in mouse, indicating a promising approach to the resolution of periodontal inflammation via stimulating the “SCC-like” function of gingival fibroblasts.
Effects of general and spinal anesthesia on postoperative rehabilitation in older adults after lower limb surgery: a retrospective cohort study
Authors: Li Guifei , Ma Qingjing , Li Yizhen , Tan Furong , Li Xuan , Chen Jie 
Published: March 2024

ObjectiveTo investigate the effects of perioperative general anesthesia (GA) and spinal anesthesia (SA) on postoperative rehabilitation in elderly patients with lower limb surgery.MethodsThis retrospective propensity score-matched cohort study included patients aged 65 years or older who underwent lower limb surgery between January 1, 2020, and May 31, 2023. The GA and SA were selected at the request of the orthopedic surgeon, patient, and their family members. The main outcomes included the incidence of the patient’s inability to self-care at discharge, postoperative complications including pulmonary infection, thrombus of lower extremity veins, infection of incisional wound and delirium, length of hospital stay, and incidence of severe pain in the first 2 days postoperatively.ResultsIn total, 697 patients met the inclusion criteria, and 456 were included in the final analysis after propensity score matching. In the GA and SA groups, 27 (11.84%) and 26 (11.40%) patients, respectively, could not care for themselves at discharge. The incidence rates did not differ between the groups (p = 0.884). In contrast, the incidence of postoperative complications (GA: 10.53% and SA: 4.39%; p = 0.013) and the length of hospital stay (GA: 16.92 ± 10.65 days and SA: 12.75 ± 9.15 days; p &lt; 0.001) significantly differed between the groups.ConclusionThe choice of anesthesia is independent of the loss of postoperative self-care ability in older patients (&gt;65 years) and is not a key factor affecting postoperative rehabilitation after lower limb surgery. However, compared with GA, SA reduces the incidence of postoperative complications and a prolonged hospital stay. Thus, SA as the primary anesthetic method is a protective factor against a prolonged hospital stay.
Altered volume of the amygdala subregions in patients with chronic low back pain
Authors: Gu Si-Yu , Shi Feng-Chao , Wang Shu , Wang Cheng-Yu , Yao Xin-Xin , Sun Yi-Fan , Hu Jian-Bin , Chen Fei , Pan Ping-Lei , Li Wen-Hui 
Published: March 2024

BackgroundNeuroimaging studies have suggested a pivotal role for the amygdala involvement in chronic low back pain (CLBP). However, the relationship between the amygdala subregions and CLBP has not yet been delineated. This study aimed to analyze whether the amygdala subregions were linked to the development of CLBP.MethodsA total of 45 patients with CLBP and 45 healthy controls (HCs) were included in this study. All subjects were asked to complete a three-dimensional T1-weighted magnetic resonance imaging (3D-T1 MRI) scan. FreeSurfer 7.3.2 was applied to preprocess the structural MRI images and segment the amygdala into nine subregions. Afterwards, comparisons were made between the two groups in terms of the volumes of the amygdala subregions. Correlation analysis is utilized to examine the relationship between the amygdala subregion and the scale scores, as well as the pain duration in patients with CLBP. Additionally, logistic regression was used to explore the risk of the amygdala and its subregions for CLBP.ResultsIn comparison to HCs, patients with CLBP exhibited a significant enlargement of the left central nucleus (Ce) and left cortical nucleus (Co). Furthermore, the increased volume of the left Ce was associated with a higher risk of CLBP.ConclusionOur study suggests that the left Ce and left Co may be involved in the pathophysiological processes of CLBP. Moreover, the volume of the left Ce may be a biomarker for detecting the risk of CLBP.
Attentional state-synchronous peripheral electrical stimulation during action observation induced distinct modulation of corticospinal plasticity after stroke
Authors: Jeong Chang Hyeon , Lim Hyunmi , Lee Jiye , Lee Hye Sun , Ku Jeonghun , Kang Youn Joo 
Published: March 2024

IntroductionBrain computer interface-based action observation (BCI-AO) is a promising technique in detecting the user's cortical state of visual attention and providing feedback to assist rehabilitation. Peripheral nerve electrical stimulation (PES) is a conventional method used to enhance outcomes in upper extremity function by increasing activation in the motor cortex. In this study, we examined the effects of different pairings of peripheral nerve electrical stimulation (PES) during BCI-AO tasks and their impact on corticospinal plasticity.Materials and methodsOur innovative BCI-AO interventions decoded user's attentive watching during task completion. This process involved providing rewarding visual cues while simultaneously activating afferent pathways through PES. Fifteen stroke patients were included in the analysis. All patients underwent a 15 min BCI-AO program under four different experimental conditions: BCI-AO without PES, BCI-AO with continuous PES, BCI-AO with triggered PES, and BCI-AO with reverse PES application. PES was applied at the ulnar nerve of the wrist at an intensity equivalent to 120% of the sensory threshold and a frequency of 50 Hz. The experiment was conducted randomly at least 3 days apart. To assess corticospinal and peripheral nerve excitability, we compared pre and post-task (post 0, post 20 min) parameters of motor evoked potential and F waves under the four conditions in the muscle of the affected hand.ResultsThe findings indicated that corticospinal excitability in the affected hemisphere was higher when PES was synchronously applied with AO training, using BCI during a state of attentive watching. In contrast, there was no effect on corticospinal activation when PES was applied continuously or in the reverse manner. This paradigm promoted corticospinal plasticity for up to 20 min after task completion. Importantly, the effect was more evident in patients over 65 years of age.ConclusionThe results showed that task-driven corticospinal plasticity was higher when PES was applied synchronously with a highly attentive brain state during the action observation task, compared to continuous or asynchronous application. This study provides insight into how optimized BCI technologies dependent on brain state used in conjunction with other rehabilitation training could enhance treatment-induced neural plasticity.
Differences in time–intensity sensory profiles of sweet taste intensity of glucose between older and young adults
Authors: Wada Hirotaka , Matsumoto Hideki , Takagiwa Mutsumi , Sato Hitomi , Ishiguchi Kyoko , Inoue Aya , Goto Tazuko K. 
Published: March 2024

BackgroundTo understand age-related changes in sweet taste perception in daily life, it is important to understand taste intensity at the suprathreshold level. Previous studies have attempted to characterize the temporal aspects of human taste perception in terms of time–intensity evaluations. The perception of dynamic taste intensity in older adults increases slowly for salty taste; however, there have been no previous studies on time–intensity sensory evaluation of sweet taste in older adults. We hypothesized that older adults perceive sweet taste intensity more slowly than young adults.MethodsFifty young and 40 older adults participated in the study and glucose solutions of 0.6 M and 1.5 M were used as stimuli. The study comprised two experiments: (1) a cup tasting test (static taste perception in the mouth), and (2) a time–intensity sensory evaluation, in which the solutions were presented using a custom-made delivery system. The intra-oral device was made to fit each participant’s dentition. Further, the level of gag reflex was taken into consideration for each participant in the design of the intra-oral device. A suction tube was placed across the posterior tongue near the throat to remove solution and saliva. The solution delivery system was controlled by an original computer program.ResultsOlder adults presented significantly different maximum intensity timing and slope for both concentrations compared with young adults (slope for 1.5 M, p &lt; 0.01; others, p &lt; 0.05). No significant differences were found between the older and young adults for reaction timing and maximum intensity.ConclusionWe conclude that older adults perceived sweetness more slowly than young adults, and ultimately perceived almost the same intensity as young adults. This is the first reported characterization of the time–intensity profile of sweet taste intensity of glucose in older adults. Using a standardized system enabled us to assess and compare feedback on taste intensities among different age groups in real-time. Based on this, we recommend older adults “savor” to perceive sweet tastes at the same level experienced by young adults.