bluuebunny/crossref_metadata_2025_split huggingface dataset:
The CARE System in Its Importance in Dealing with Today's Crises1
Authors: Kast Verena 
Published: March 2024

AbstractThe CARE system is a gift from Mother Nature, we have it in our biological heritage; it enables us humans—as a basic gift—to help each other in a large, life‐serving context, and thus also to counterbalance destruction. It is about a basic human ability, linked to typical behaviour, but also about a basic human need for connectedness. In this paper, I would like to show how the CARE system can be activated as a collective attitude.The CARE system is strengthened by positive emotions. We are currently being affected by many crises and this triggers fear. How can we deal with this better? Fear is countered with hope and the associated positive emotions such as joy, awe, kama muta and others. These emotions and feelings can be consciously encouraged and placed alongside the feelings of fear. But also, when we share the feelings of grief with each other, it triggers an attitude of CARE. We can grieve together for the various experiences of loss that we go through—but we can also imagine together how we envisage a future that is worth living for everyone.An attitude in the sense of CARING has been practised in friendship for thousands of years. It would therefore be possible to move away from an attitude of competing and outdoing, to an attitude not only of recognition, care, and solidarity in human interaction, but also in our connection with nature.
Unhinged: A Prospective Perspective on Being Unsafe1
Authors: Houck Tiffany N. 
Published: March 2024

AbstractGiven the unprecedented events unfolding around the globe over the past four years, psychoanalytic communities near and far have sought to ask and ventured to answer the question: What does psychoanalysis have to offer individuals, and the collective, as a way of seeing and being with the reality of what is? Taking up these questions in such a time as this, feels, perhaps inevitably, unsafe. Sometimes it can feel as if there is a silent and unspoken mandate to ensure safety at all costs when we seek to find a spirit of the depth’s response to the spirit of the times. I propose that the work of psychoanalysis is grounded in nothing but the journey through that which is unsafe. This article will take up Ann Ulanov’s notion that one’s own evil is the hinge door into collective and archetypal evil. To become unhinged means to risk well‐formulated understandings, theories, and modalities about being and becoming for the other and instead to allow the other to penetrate that which is unknown in ourselves, upending our well‐formed theories and pressing us to take up our own lives in new and unpredictable ways.
Metabolic rewiring enables ammonium assimilation via a non‐canonical fumarate‐based pathway
Authors: Mardoukhi Mohammad Saba Yousef , Rapp Johanna , Irisarri Iker , Gunka Katrin , Link Hannes , Marienhagen Jan , de Vries Jan , Stülke Jörg , Commichau Fabian M. 
Published: March 2024

AbstractGlutamate serves as the major cellular amino group donor. In Bacillus subtilis, glutamate is synthesized by the combined action of the glutamine synthetase and the glutamate synthase (GOGAT). The glutamate dehydrogenases are devoted to glutamate degradation in vivo. To keep the cellular glutamate concentration high, the genes and the encoded enzymes involved in glutamate biosynthesis and degradation need to be tightly regulated depending on the available carbon and nitrogen sources. Serendipitously, we found that the inactivation of the ansR and citG genes encoding the repressor of the ansAB genes and the fumarase, respectively, enables the GOGAT‐deficient B. subtilis mutant to synthesize glutamate via a non‐canonical fumarate‐based ammonium assimilation pathway. We also show that the de‐repression of the ansAB genes is sufficient to restore aspartate prototrophy of an aspB aspartate transaminase mutant. Moreover, in the presence of arginine, B. subtilis mutants lacking fumarase activity show a growth defect that can be relieved by aspB overexpression, by reducing arginine uptake and by decreasing the metabolic flux through the TCA cycle.
China's reaction to the Russia–Ukraine war: A test case for a global ‘Pax Sinica’?
Authors: Düben Björn Alexander 
Published: March 2024

AbstractThis article examines the Chinese government's stance on the Russia–Ukraine war, including the recent development of China's economic relations with Russia. It assesses the factors that have influenced Beijing's position and the narrative it has used to explain it. Considering China's outsized importance for global events, the article also explores what implications its positioning regarding the war can have for the future of the global order. Since Russia's invasion began, China's government has presented itself as a neutral party, but it has de facto adopted a pro‐Russian position in the conflict. Beijing has primarily framed its stance on Ukraine in security terms, embedded in what is essentially a Realist narrative interlinked with pre‐existing ideological worldviews among China's political elites. It has condoned Russia's invasion on the grounds that Moscow is defending its ‘legitimate security interests’, which is an implicit appeal to respect a great power's sphere of influence, even at the expense of smaller states' sovereignty. While this raises questions about the compatibility of Beijing's vision of global order with the broader interests of most other states of the Global South, China (alongside Russia) has intensified its efforts to court these states in the context of the Russia–Ukraine war.
An investigation into the utility of eastern barn owl pellet content as a tool to monitor small mammal diversity in an arid ecosystem
Authors: Schoenefuss Pia , Kutt Alex S. , Kern Pippa L. , Moffatt Kate A. , Bon Joshua , Wardle Glenda M. , Dickman Chris R. , Hurwood David A. , Baker Andrew M. 
Published: March 2024

AbstractConsidering several logistical limitations associated with live trapping in arid environments, owl pellet analysis provides a potentially useful alternative to estimate small mammal diversity. Owl pellet analysis has been used to estimate local small mammal diversity under the assumption that the method can reliably reflect the composition of local small mammal assemblages. However, the validity of owl pellet contents for use in ecological assessments has not been established. Thus, the present study aimed to determine the potential for eastern barn owl (Tyto delicatula) pellet analysis to improve the monitoring of small mammals in arid Australia. We analysed two ecological datasets from Pilungah Reserve on the northern boundary of the Simpson Desert in central Australia to assess their effectiveness for detecting expected small mammal species: 250 owl pellets collected from a known roosting site and 5 years of small mammal records from historical, long‐term trapping surveys. Species composition and detection probability of mammals varied depending on the method used. Owl pellet analysis returned higher species richness overall, while traditional trapping methods indicated a higher probability of detecting certain mammal species (e.g., the wongai ningaui Ningaui ridei, brush‐tailed mulgara Dasycercus blythi and the hairy‐footed dunnart Sminthopsis hirtipes). Importantly, analysis of owl pellets revealed two mammal species that had never been detected at the study site (dusky hopping mouse Notomys fuscus and Carpentarian false antechinus Pseudantechinus cf. mimulus). We suggest that owl pellet analysis could be particularly valuable when used as a precursor or in concert with traditional trapping to monitor and assist in the conservation of small mammal species in arid environments.
Breastmilk calcium concentrations in Palestinian lactating women
Authors: Shawahna Ramzi , Abdi Aya , Bani‐Odeh Diana , Saleh Rana , Owiwi Lina , Maqboul Iyad , Hijaz Hatim , Jaber Mohammad 
Published: March 2024

AbstractAimBreastmilk calcium concentrations can vary between lactating women and over the lactation period. This study assessed breastmilk calcium concentrations among Palestinian lactating women.MethodsThe demographic and dietary variables of the lactating women were collected using a questionnaire. The women provided a sample of about 5 mL of breastmilk using hand expression. Breastmilk calcium concentrations were quantified using an inductively coupled plasma‐mass spectrometric method.ResultsBreastmilk samples were taken from 240 lactating women. The mean breastmilk calcium concentration was 285.4 ± 115.1 mg/L. Lower breastmilk calcium concentrations were associated with age, lactating period, unemployment, dissatisfaction with income and insufficient consumption of vitamins and minerals.ConclusionBreastmilk calcium concentrations were affected by demographic variables of the lactating women and insufficient consumption of vitamins and minerals. The findings reported in this study are informative to healthcare providers and decision makers who might be interested in improving the health of lactating women and their infants.
Von Willebrand factor for outcome prediction within different clinical stages of advanced chronic liver disease
Authors: Dominik Nina , Scheiner Bernhard , Zanetto Alberto , Balcar Lorenz , Semmler Georg , Campello Elena , Schwarz Michael , Paternostro Rafael , Simbrunner Benedikt , Hofer Benedikt S. , Stättermayer Albert Friedrich , Pinter Matthias , Trauner Michael , Quehenberger Peter , Simioni Paolo , Reiberger Thomas , Mandorfer Mattias 
Published: March 2024

SummaryBackground and AimsThe prognostic performance of von Willebrand factor (VWF) may vary across clinical stages of advanced chronic liver disease (ACLD). Therefore, we investigated the evolution of VWF and other biomarkers throughout the full ACLD spectrum and evaluated their stage‐specific prognostic utility.MethodsWe retrospectively included Viennese ACLD patients with available information on hepatic venous pressure gradient (HVPG), C‐reactive protein (CRP)/VWF levels and outcomes. ACLD stages were defined according to D'Amico et al. We included an external validation cohort from Padua.ResultsWe observed gradual increases in VWF throughout ACLD stages. In contrast, HVPG levelled off in decompensated ACLD (dACLD), whereas MELD showed only minor changes in the early stages and CRP did not increase until stage 3. VWF was associated with hepatic decompensation/liver‐related death in compensated ACLD (cACLD) in a fully adjusted model, while it was not independently predictive of ACLF/liver‐related death in dACLD. After backward selection, HVPG/CRP/VWF remained the main predictors of hepatic decompensation/liver‐related death in cACLD. Notably, the performance of the non‐invasive CRP/VWF‐based model was comparable to invasive HVPG‐based models (C‐index:0.765 ± 0.034 vs. 0.756 ± 0.040). The discriminative ability of the CRP/VWF‐based model was confirmed in an external validation cohort using another VWF assay which yielded systematically lower values.ConclusionVWF is the only biomarker that gradually increases across all ACLD stages. It is of particular prognostic value in cACLD, where a CRP/VWF‐based model is equivalent to an invasive HVPG‐based model. Systematic differences in VWF underline the importance of interlaboratory surveys. Moreover, our findings reinforce the notion that, already in cACLD, inflammation is a key disease‐driving mechanism.
Technology‐supported cooperative learning as a universal mental health intervention in middle and high school
Authors: Zagni Benedetta , Van Ryzin Mark J. 
Published: March 2024

AbstractBackgroundAdolescent mental health issues are a major public health concern, highlighted by the US Surgeon General as a crisis. Traditional school‐based interventions show inconsistent success, creating a demand for effective solutions.AimsThis study evaluates the impact of technology‐supported cooperative learning (CL) on adolescent mental health, focusing on positive peer relations and peer victimization.Materials and MethodsParticipants included 813 adolescents (50.2% female; 70.7% White) from 12 middle and high schools in the Pacific Northwest. The study used hierarchical linear modelling (HLM) to assess the effectiveness of CL facilitated via PeerLearning.net.ResultsImplementing CL led to significant improvements in peer relations and reductions in victimization and mental health problems, with moderate‐to‐large effect sizes observed across different demographics. Positive peer relations significantly predicted lower victimization and improved mental health.DiscussionThe findings highlight the potential of technology‐supported CL in addressing adolescent mental health by enhancing protective factors and reducing risks. Such interventions offer a scalable and sustainable approach for schools to address mental health challenges.ConclusionTechnology‐supported cooperative learning offers a promising strategy for improving adolescent mental health, demonstrating significant benefits in peer relations and reducing victimization. This approach provides schools with an accessible and effective tool to tackle the mental health crisis among students.
Mapping the self in self‐regulation using complex dynamic systems approach
Authors: Saqr Mohammed , López‐Pernas Sonsoles 
Published: March 2024

Complex dynamic systems offer a rich platform for understanding the individual or the person‐specific mechanisms. Yet, in learning analytics research and education at large, a complex dynamic system has rarely been framed, developed, or used to understand the individual student where the learning process takes place. Individual (or person‐specific) methods can accurately and precisely model the individual person, create person‐specific models, and devise unique parameters for each individual. Our study used the latest advances in complex systems dynamics to study the differences between group‐based and individual self‐regulated learning (SRL) dynamics. The findings show that SRL is a complex, dynamic system where different sub‐processes influence each other resulting in the emergence of non‐trivial patterns that vary across individuals and time scales, and as such far from the uniform picture commonly theorized. We found that the average SRL process does not reflect the individual SRL processes of different people. Therefore, interventions derived from the group‐based SRL insights are unlikely to be effective in personalization. We posit that, if personalized interventions are needed, modelling the person with person‐specific methods should be the guiding principle. Our study offered a reliable solution to model the person‐specific self‐regulation processes which can serve as a ground for understanding and improving individual learning and open the door for precision education.Practitioner notesWhat is already known about this topicSelf‐regulation is a catalyst for effective learning and achievement.Our understanding of SRL personalization comes from insights based on aggregate group‐based data.What this paper addsEvery student has their own unique SRL process that varies from the average in non‐trivial ways.We offer a credible method for mapping the individualized SRL process.SRL dynamics vary across time scales. That is, the trait dynamics are different from the state dynamics, and they should be supported differently.Implications for practice and/or policyPersonalization can best be achieved if based on unique person‐specific idiographic methods.Supporting learning and SRL in particular can be more efficient when we understand the differences across time scales and persons and apply insights accordingly.The general SRL average should not be expected to work for everyone.
Refining risk stratification in paediatric B‐acute lymphoblastic leukaemia: Combining IKZF1plus and Day 15 MRD positivity
Authors: Liu Hsi‐Che , Huang Ying‐Jung , Jaing Tang‐Her , Wu Kang‐Hsi , Chen Shih‐Hsiang , Wang Shih‐Chung , Yeh Ting‐Chi , Hsiao Chih‐Cheng , Chang Te‐Kau , Yen Hsiu‐Ju , Huang Fang‐Liang , Lin Pei‐Chin , Hou Jen‐Yin , Sheen Jiunn‐Ming , Liao Yu‐Mei , Chang Tsung‐Yen , Chen Yu‐Chieh , Chiou Shyh‐Shin , Yang Chao‐Ping , Pui Ching‐Hon , Liang Der‐Cherng , Shih Lee‐Yung 
Published: March 2024

SummaryThis study investigates the potential utility of IKZF1 deletion as an additional high‐risk marker for paediatric acute lymphoblastic leukaemia (ALL). The prognostic impact of IKZF1 status, in conjunction with minimal/measurable residual disease (MRD), was evaluated within the MRD‐guided TPOG‐ALL‐2013 protocol using 412 newly diagnosed B‐ALL patients aged 1–18. IKZF1 status was determined using multiplex ligation‐dependent probe amplification. IKZF1 deletions, when co‐occurring with CDKN2A, CDKN2B, PAX5 or PAR1 region deletions in the absence of ERG deletions, were termed IKZF1plus. Both IKZF1 deletion (14.6%) and IKZF1plus (7.8%) independently predicted poorer outcomes in B‐ALL. IKZF1plus was observed in 4.1% of Philadelphia‐negative ALL, with a significantly lower 5‐year event‐free survival (53.9%) compared to IKZF1 deletion alone (83.8%) and wild‐type IKZF1 (91.3%) (p < 0.0001). Among patients with Day 15 MRD ≥0.01%, provisional high‐risk patients with IKZF1plus exhibited the worst outcomes in event‐free survival (42.0%), relapse‐free survival (48.0%) and overall survival (72.7%) compared to other groups (p < 0.0001). Integration of IKZF1plus and positive Day 15 MRD identified a subgroup of Philadelphia‐negative B‐ALL with a 50% risk of relapse. This study highlights the importance of assessing IKZF1plus alongside Day 15 MRD positivity to identify patients at increased risk of adverse outcomes, potentially minimizing overtreatment.
Do unions increase participation in further education?
Authors: Kostøl Fredrik B. 
Published: March 2024

AbstractThe race between education and technology is a key issue for trade unions. Unions often include skill upgrading and training in collective bargains, which might be an important tool to facilitate lifelong learning. In this article, I investigate how trade unions influence workers’ participation in further education using Norwegian‐matched employer–employee panel data on full‐time workers and a fixed‐effects framework. In contrast to most existing studies, which rely on more or less representative surveys, our data comprise the entire working population over a period of 16 years, allowing us to control for unobserved individual heterogeneity. An increase in the workplace union density is estimated to raise the individual propensity to participate in tertiary vocational education. I also find that workers in unionized establishments enjoy higher salaries during further education but at the expense of lower post‐training wage premiums. In addition, unions are found to lower employee turnover. Together, these findings give empirical support to the theoretical prediction of Acemoglu and Pischke (1999), where firms may optimally choose to sponsor investments in workers’ skills in the absence of perfect competition in the labour market.
Addition of neoadjuvant chemotherapy to a ‘quadrifecta’ composite in radical cystectomy
Authors: D’Andrea David , Soria Francesco , Moschini Marco , Laukhtina Ekaterina , Hurle Rodolfo , Mancon Stefano , Antonelli Alessandro , Teoh Jeremy Yuen‐Chun , Shariat Shahrokh F. , Pradere Benjamin 
Published: March 2024

ObjectivesTo evaluate the impact of incorporating neoadjuvant chemotherapy (NAC) into the ‘quadrifecta’ outcomes composite for reporting outcomes of radical cystectomy (RC) creating a pentafecta score.Patients and MethodsThis is a retrospective multicentre analysis of patients treated with RC, with or without NAC, for bladder cancer between 2002 and 2023. The primary outcome was the effect of adding NAC to a quadrifecta outcomes composite on cancer‐specific (CSS) and overall survival (OS). The quadrifecta outcomes composite included a yield of ≥16 lymph nodes, negative soft tissue surgical margin, absence of major complication within 30 days from surgery, and no delay in RC.ResultsA total of 590 patients were included in the analyses. A total of 233 (39.5%) patients achieved all quadrifecta outcomes and 82 (13.9%) patients were additionally treated with NAC, achieving the pentafecta. Achieving the quadrifecta outcomes composite was significantly associated with better CSS (hazard ratio [HR] 0.49, 95% confidence interval [CI] 0.32–0.75; P = 0.001) and OS (HR 0.48, 95% CI 0.34–0.69; P < 0.01). The addition of NAC to the quadrifecta composite outcomes significantly improved the discrimination of patients more likely to have better CSS (HR 0.21, 95% CI 0.08–0.57; P = 0.002) and OS (HR 0.26, 95% CI 0.12–0.55; P < 0.01).ConclusionWe propose a new pentafecta that may serve as a tool for standardising outcomes reporting and measuring the quality of RC.
Flubendazole suppresses VEGF‐induced angiogenesis in HUVECs and exerts antitumor effects in PC‐3 cells
Authors: Zhang Baoyue , Zhao Jun , Kang De , Wang Zhe , Xu Lvjie , Zheng RuiFang , Liu Ailin 
Published: March 2024

AbstractFlubendazole, an FDA‐approved anthelmintic, has been predicted to show strong VEGFR2 inhibitory activity in silico screening combined with in vitro experimental validation, and it has shown anti‐cancer effects on some human cancer cell lines, but little is known about the anti‐angiogenesis effects and anti‐prostate cancer effects. In this study, we analyzed the binding modes and kinetic analysis of flubendazole with VEGFR2 and first demonstrated that flubendazole suppressed VEGF‐stimulated cell proliferation, wound‐healing migration, cell invasion and tube formation of HUVEC cells, and decreased the phosphorylation of extracellular signal‐regulated kinase and serine/threonine kinase Akt, which are the downstream proteins of VEGFR2 that are important for cell growth. What's more, our results showed that flubendazole decreased PC‐3 cell viability and proliferation ability, and suppressed PC‐3 cell wound healing migration and invasion across a Matrigel‐coated Transwell membrane in a concentration‐dependent manner. The antiproliferative effects of flubendazole were due to induction of G2‐M phase cell cycle arrest in PC‐3 cells with decreasing expression of the Cyclin D1 and induction of cell apoptosis with the number of apoptotic cells increased after flubendazole treatment. These results indicated that flubendazole could exert anti‐angiogenic and anticancer effects by inhibiting cell cycle and inducing cell apoptosis.
If not angioedema, what is it? Diagnostic approach to facial edema
Authors: Velasco‐Amador Juan Pablo , Prados‐Carmona Álvaro , Navarro‐Triviño Francisco José 
Published: March 2024

SummaryFacial edema is a relatively frequent clinical presentation encountered in patients seen in allergology and dermatology clinics. The differential diagnosis is broad, and sometimes the definitive diagnosis can be a challenge for the clinician. Facial angioedema itself encompasses different etiopathologies (histaminergic, bradykinergic, etc.) that must be distinguished from other causes of facial edema, such as allergic contact dermatitis, granulomatous conditions, inflammatory causes, infections, neoplasms or paraneoplastic syndromes, autoimmune diseases, among other entities hereby referred as miscellanea. A proper diagnostic approach is essential to order the appropriate tests, as well as to prescribe a targeted treatment. This review focuses on entities that present with facial edema and summarize their characteristic clinical features.