bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytologic evaluation of tumors of the orbit and ocular adnexa: An analysis of 84 cases studied by the “squash technique”
Authors: Font Ramon L. , Laucirica Rodolfo , Ramzy Ibrahim 
Published: February 2007

AbstractThe cytologic features of 84 ophthalmic lesions were evaluated using the squash technique at the time of frozen section. Of the 84 lesions, 55 were located in the orbit, 17 in the lacrimal gland, and 12 in the ocular adnexa. Lymphoid lesions comprised most of the cases (n=47). In this group, 34 cases were malignant lymphomas and 13 were lymphoid hyperplasias. Inflammatory/granulomatous lesions and mesenchymal tumors comprised eight cases each. Epithelial neoplasms of the soft tissues of the orbit, lacrimal gland and eyelid constituted 12 cases, of which eight were malignant and four were benign. A total of nine cases were due to neurogenic tumors, neuroendocrine neoplasms, and melanocytic tumors.The squash technique provides a means to evaluate the architectural and cytologic details of ophthalmic lesions, without the intrinsic problem of frozen section artifact. We believe that the squash technique is a simple, quick, and useful method for the diagnosis of orbital/adnexal lesions. © 1994 Wiley‐Liss, Inc.
Ductal adenoma of the breast: The cytological features of six cases
Authors: Jensen Marianne Lidang , Johansen Preben , Noer Hanne , Sørensen Inge Marie 
Published: February 2007

AbstractDuctal adenoma of the breast may simulate malignancy by both clinical, histological, and cytological examination. Fine‐needle aspirations from breast lesions are now daily routine and preoperative recognition of this benign lesion is desirable. This study describes the cytologic features of six additional cases of ductal adenoma. The smears from all the lesions were highly cellular with epithelial cells in sheets. Numerous large fragments of purple stroma in tight connection with epithelial cells often making finger‐like hyaline structures or globules between cells were seen. Naked oval nuclei in the background were observed in all cases indicating benignancy.We find the cytologic picture in fine‐needle aspirations from ductal adenomas sufficiently characteristic for preoperative diagnosis. The differential diagnoses toward other benign and malignant conditions are discussed. © 1994 Wiley‐Liss, Inc.
Chondroid syringoma diagnosed by fine‐needle aspiration: A case report
Authors: Gottschalk‐Sabag Shoshana , Glick Tzipporah 
Published: February 2007

AbstractWe describe a case of an 82‐yr‐old woman presenting with a thyroid nodule and axillary mass thought to be a metastasis. Fine‐needle aspiration (FNA) revealed the axillary nodule to be a chondroid syringoma. We report here the cytologic features of chondroid syringoma and recommend the use of FNA in the evaluation of cutaneous and subcutaneous lesions in general. © 1994 Wiley‐Liss, Inc.
Efficacy of the cytobrush method in aged patients
Authors: Koike Noboru , Kasamatsu Takahiro 
Published: February 2007

AbstractTo evaluate the efficacy of the Cytobrush method in aged patients, a comparative study between the Cytobrush smears and cotton swab smears from the uterine cervix was performed. Consecutive 319 cotton swab smears of the endocervix were attempted on aged patients (60‐98 yr, average 77.5 yr) from 1987 to 1988 (A group). Subsequently 391 endocervical smears were attempted by the Cytobrush on aged patients (60‐100 yr, average 76.9 yr) from 1988 to 1990 (B group). The Cytobrush method was more effective in the following two points: (1) The rate of insert‐impossible case in B group (7.2%) was lower than A group (12.5%). (2) The rate of case containing endocervical columnar cells increased in B group (64.7%) compared with A group (47.7%). In contrast, benign epithelial fragments (BFs) were observed in 6.8% of A, in 28.4% of B group. In smears positive for squamous cancer, malignant epithelial fragments (MFs) were noted in 24.5% of A, and 55.1% of B group. Consequently, the differential diagnosis of MFs from BFs is of more importance on the Cytobrush smears of aged patients. © 1994 Wiley‐Liss, Inc.
Jack fruit lectin‐specific glycoconjugate expression during the progression of cervical intraepithelial neoplasia: A study on exfoliated cells
Authors: Pillai K. Raveendran , Remani P. , Kannan S. , Mathew Aleyamma , Sujathan K. , Vijayakumar T. , Nair M. Krishnan 
Published: February 2007

AbstractThe expression of glycoconjugates specific to Jack fruit lectin (JFL) was studied in the exfoliated squamous cells of different grades of intraepithelial and invasive neoplasia of the uterine cervix. It was observed that while normal cells showed almost negative binding, the lectin binding percentage of squamous cells signficantly increased with increasing atypia of the epithelium. Correlation analysis between different groups revealed that mild lectin binding in cells had a negative correlation and intense binding had a positive correlation with various stages of tumor progression. These results indicate that the number of cells with aberrant expression of glycoconjugates increases as neoplastic transformation advances. The percentage of labeled and unlabeled cells also shows a continuous transition from low to severe grades of cervical intraepithelial neoplasia and invasive carcinomas. The present study therefore shows that JFL may be used as a probe for further elaboration of detection and grading of precancerous and cancerous lesions of the uterine cervix. © 1994 Wiley‐Liss, Inc.
Metastatic adamantinoma diagnosed by fine‐needle aspiration biopsy of the lung
Authors: Perez‐Ordonez Bayardo , Bedard Yvan C. 
Published: February 2007

AbstractWe report two cases of metastatic adamantinoma to the lung diagnosed by FNAB. The cytologic appearance of the smears of each case was homogenous, containing small round and spindle cells with indistinct cytoplasm. The nuclei had delicate nuclear membranes, with finely dispersed chromatin and occasional micronucleoli. No pleomorphism was noted. Immunocytochemistry exhibited positive staining for keratin and vimentin. EM examination revealed numerous tonofilaments and well formed desmosomes. The cytologic diagnosis of metastatic adamantinoma can be made with the knowledge of a previous history of adamantinoma of bone, the comparison of the metastatic tumor with the original bone tumor, and the awareness of the long latency of the metastases. Immunocytochemistry and EM are needed to substantiate the diagnosis. © 1994 Wiley‐Liss, Inc.
Fine‐needle aspiration of pancreatic extramedullary plasmacytoma: Possible confusion with islet cell tumor
Authors: Dodd Leslie G. , Evans Douglas B. , Symmans Fraser , Katz Ruth L. 
Published: February 2007

AbstractWe report two cases of extramedullary plasmacytoma (EMP) of the pancreas, diagnosed by fine‐needle aspiration (FNA). Plasmacytoma of the pancreas is a rare neoplasm with only 12 cases recorded in the literature. Because of its scarcity and the cytomorphologic similarity between plasma cells and endocrine cells, EMP of the pancreas may be confused with neuroendocrine (islet cell) tumors of the pancreas. Immunohistochemical staining for light chain and/or neuroendocrine markers will prevent diagnostic error when interpreting plasmacytoid neoplasms of any site susceptible to endocrine tumors, including the pancreas. © 1994 Wiley‐Liss, Inc.
Fine‐needle aspiration cytology of cystic ovarian lesions
Authors: Wojcik Eva M. , Selvaggi Suzanne M. 
Published: February 2007

AbstractA 4‐year study (January 1986 through December 1990) was performed to evaluate the cytomorphologic features of cystic ovarian lesions. Fluid from 103 cases was obtained either during surgical removal of the ovary (48 cases; mean age 50 years) or by fine needle aspiration (55 cases; mean age 32 years). Of the 48 cystic lesions with histologic correlation, 30 (62.5%) were neoplastic and 18 (37.5%) were non‐neoplastic. Ten (18%) of the 55 aspirates were unsatisfactory. The remaining 45 cases (82%) were benign, predominantly non‐neoplastic entities which included follicle, corpora luteal, and endometriotic cysts. Neoplastic cystic lesions included serous, mucinous, and Brenner tumors, germ cell neoplasms, a sex cord‐stromal tumor, and an undifferentiated carcinoma. Follicle and corpora luteal cysts were composed of loose cell clusters of granulosa cells and/or luteinized granulosa cells. Endometriotic cysts contained hemosiderin‐laden macro‐phages and endometrial cells. Serous and mucinous cystadenomas were composed of cohesive sheets and/or papillary clusters of epithelial cells. A cystic Brenner tumor showed sheets of cells with grooved nuclei, and a benign cystic teratoma contained mature squamous cells admixed with vacuolated cells of presumed sebaceous origin. Although the distinction between benign and malignant entities posed few diagnostic difficulties, borderline tumors could not be distinguished from well‐differentiated cystadenocarcinomas. The results of this study indicate that the majority of cystic ovarian lesions can be diagnosed accurately on cytology. Cytologic evaluation of non‐neoplastic ovarian cysts is important for women who want to retain their fertility and in the clinical management of women with neoplastic lesions. Diagn Cytopathol 1994; 11:9–14. © 1994 Wiley‐Liss, Inc.
Expression of proliferating cell nuclear antigen, Ki‐67 antigen, estrogen receptor protein, and tumor suppressor p53 gene in cytologic samples of breast cancer: An immunochemical study with clinical, pathobiological, and histologic correlations
Authors: Pelosi Giuseppe , Bresaola Enrica , Rodella Stefania , Manfrin Erminia , Piubello Quirino , Schiavon Ivana , Lannucci Antonio 
Published: February 2007

AbstractSixty‐six unselected breast cancers were analyzed in cytologic smears and histologic sections for the expression of Ki‐67, proliferating cell nuclear antigen (PCNA). estrogen receptor protein (ERP), and p53 protein using a standard immunochemical method. The results, expressed as both positive cases and labelling index (LI), were compared with clinical and pathobiological variables. Ki‐67 and PCNA immunostaining was seen in all cases, whereas ERP was detectable in 46/63 cases and p53 protein in 20/66 cases. The expression of these markers was generally lower in cytology than in histology, though the differences were not statistically significant. PCNA‐LI and Ki‐67‐LI were closely correlated (P < 0.001), the mean PCNA:Ki‐67 ratio being 0.92 ± 0.57. Occasional discrepancies, however, were found. PCNA and Ki‐67 expression was associated with an increase in histologic grade and a decrease in ERP content of tumors, whereas p53 was statistically associated with no clinical or pathobiological variables. The data suggest that proliferative activity and oncogene overexpression may be reliably evaluated in breast cancer by FNA cytology, though PCNA is not a suitable indicator for cell proliferation. The results do not resolve the issue as to whether immunostaining for p53 protein constitutes a dedifferentiation product of the tumor, or is a fundamental aspect of the malignant progression. Survival studies in a larger series of tumors are thus needed to elucidate this point. Diagn Cytopathol 1994; 11:131–140. © 1994 Wiley‐Liss, Inc.
Cutaneous T‐cell lymphoma diagnosed by fine‐needle aspiration: A case report with clinical, cytological, and immunophenotypic features
Authors: Basu Debdatta , Kumar Surinder , Shome Durjoy K. , Chauhan Susheela 
Published: February 2007

AbstractA case study of cutaneous T‐cell lymphoma in a 40‐yr‐old Indian male is presented. Prominent clinical features consisted of large skin tumours, lymphidenopathy, and a rapidly progressive course of development. Aspiration smears from tumours, lymph nodes, and bone marrow showed pleomorphic Sezary cells and lymphoid blasts. The neoplastic cells stained positively with anti‐HLA DR, CD1, and CD2 antibodies and showed lack of T‐cell subset antigens CD4 and CD8. Numerous proliferating cells were identified with 56% of bone marrow cells and 57% of cells in the dermis staining positively with Ki‐67 and PC10 antibodies, respectively. This case is reported in view of its uncommon features. Diagn Cytopathol 1994;11:174–177. © 1994 Wiley‐Liss, Inc.
Markers for metastatic adenocarcinoma in serous effusion specimens
Authors: Shield P. W. , Callan J. J. , Devine P. L. 
Published: February 2007

AbstractA variety of stains have been proposed as useful adjuncts to the morphologic diagnosis of serous effusion specimens. This study evaluates the sensitivity and specificity of nine stains for the detection of metastatic adenocarcinoma in effusions.Mucin cytochemistry with the Periodic acid‐Schiff reaction after diastase digestion (PASd) and the mucicarmine method, as well as immunochemical staining for five glycoprotein antigens, was undertaken on 153 effusion specimens with histological and/ or clinically confirmed diagnoses. Immunochemical stains included three antibodies to CEA (Dako polyclonal, 4E7 and A5 B7) and antibodies to HEA (Ber‐EP4), TAG 72 (B 72.3), CD15 (LeuMl) and Epithelial membrane antigen (EMA) were evaluated.The sensitivity of the stains for adenocarcinoma (102 cases) was: PASd 37%; mucicarmine 24%; polyclonal anti‐CEA 69%; 4E7 52%; A5B7 21%; EMA 91%; B72.3 44%; Ber‐EP4 32%; LeuMl 24%. With the exception of EMA, none of the stains reacted with any cases of benign mesothelial cells (11 cases), reactive mesothelial cells (34 cases), or with six cases of mesothelioma. However, EMA staining was present in two cases (6%) of reactive mesothelial cells and all cases of mesothelioma. The optimal combination of stains for use in a panel was polyclonal anti‐CEA/B72.3/PASd. Combined results from these three stains yielded a sensitivity of 83% for adenocarcinoma with no false positive results. It is concluded that special staining may provide valuable information to assist in the classification of difficult effusion cases. Diagn Cytopathol 1994;ll:237–245. © 1994 Wiley‐Liss, Inc.
Metastatic medullary thyroid carcinoma in liver diagnosis by aspiration cytology
Authors: Gomez‐Fernandez Carmen , Kraemer H. John , Ganjei Parvin 
Published: February 2007

AbstractA case of metastatic medullary thyroid carcinoma (MTC) to the liver of a patient with multiple endocrine neoplasia (MEN) Type IIb was suggested by percutaneous fine‐needle aspiration cytology and confirmed by histology and immunohistochemistry. The cytologic presentation of this unusual thyroid cancer in liver has not been previously reported. We report such a case and discuss its differential diagnosis from other metastatic tumors of the liver. Diagn Cytopathol 1994; 11:277–280. © 1994 Wiley‐Liss, Inc.
Ultrasonically guided fine‐needle aspiration biopsy of portal vein thrombosis: A cytomorphological study of 14 patients
Authors: Adeyanju Moses O. , Dodd Gerald D. , Madariaga Juan R. , Dekker Andrew 
Published: February 2007

AbstractPortal vein tumor thrombosis is an important and consistent prognostic indicator in hepatocellular carcinoma. We reviewed 14 cases of ultrasonically guided fine‐needle aspiration biopsy (FNAB) of the portal vein. All the patients had clinical evidence of portal vein thrombosis (PVT). Twelve of these patients had a preliminary diagnosis of hepatocellular carcinoma while the remaining two, initially, had a clinical diagnosis of end‐stage liver disease. The mean age of the patients was 60 years. An average of 1.7 passes per case was made. No clinical complications were encountered. The cytomorphologic features of the aspirated materials were reviewed. Twelve of the 14 cases (85.7%) were judged neoplastic or thought to have probable neoplastic involvement of the portal vein while two were clearly benign. The cell block was found to be the most useful in diagnosis. We conclude that FNAB of the portal vein is a feasible method in evaluating PVT, especially in patients already known to have hepatocellular carcinoma. Diagn Cytopathol 1994; 11:281–285. © 1994 Wiley‐Liss, Inc.
Fine‐needle aspiration cytology of hepatic leiomyosarcoma
Authors: Smith Michael B. , Silverman Jan F. , Raab Stephen S. , Towell Brian D. , Geisinger Kim R. 
Published: February 2007

AbstractHepatic leiomyosarcoma is a rare malignancy to involve the liver, occurring as a primary liver sarcoma in patients without an underlying medical disorder, as a metastatic malignancy, and with increasing incidence, as a primary tumor in AIDS patients. A series of hepatic leiomyosarcomas diagnosed by FNA biopsy, including the first reported case in an adult AIDS patient, were reviewed with respect to cytomorphologic features. The series consisted of five men and two women ranging from 24 to 72 years of age. One case was a primary hepatic lesion in a 24‐yr‐old man with AIDS and six were metastatic from a number of sites (stomach, small bowel, retroperitoneum, vena cava, and seminal vesicle). Two cytologic patterns were identified. Aspirates of spindle‐cell leiomyosarcomas (six cases) generally produced hypocellular smears composed primarily of small irregular clusters of cells with blunt‐ended, uniform, overlapping nuclei. The differential diagnosis included benign reactive processes and other benign and malignant spindle‐cell neoplasms. The aspirate of an epithelioid leiomyosarcoma (one case) revealed a second pattern characterized by highly cellular smears with many single polygonal cells having eccentric, malignant nuclei and a characteristic clear quality to the cytoplasm in Papanicolaou‐stained material. This epithelial appearance generated a differential diagnosis that included hepatocellular carcinoma, metastatic carcinoma, and melanoma. Careful integration of clinical information, cytomorphologic features, and ancillary studies will allow specific FNA diagnosis of hepatic leiomyosarcoma in most cases. Diagn Cytopathol 1994;11:321–327. © 1994 wiley‐Liss, Inc.
Lacrimal gland lymphoma: A cytomorphologic and immunophenotypic study
Authors: Brian Jeffrey P. , Cartwright David , Atwater Susan K. , Char Devron H. , Miller Theodore R. 
Published: February 2007

AbstractThe cytomorphology of lacrimal gland lymphoma has not been specifically described. Herein we present six cases of histologically proven lacrimal gland lymphoma which we analyzed using fine‐needle aspiration cytology, cell suspension immunophenotype analysis, and immunoglobulin gene rearrangement studies. Fine‐needle aspiration cytology revealed atypical populations of cells comprised of either monomorphic small round lymphocytes with or without plasmacytoid features (4 cases), a mixed population of small and large irregular lymphocytes (1 case), or a population of large irregular lymphocytes (1 case). the initial cytologic diagnosis was malignant lymphoma in all six cases. Cell suspension immunophenotype analysis demonstrated that the lesions were composed predominantly of B‐cells that expressed monotypic surface immunoglobulin. Three cases demonstrated an immunoglobulin heavy chain gene rearrangement. the atypical cytologic features and the abnormal immunophenotype were consistently predictive of malignant lymphoma. Given that these lesions are small and biopsy material is often limited, fine‐needle aspiration offers the advantage of providing tissue that is ideal for cytologic and cell suspension immunophenotype evaluation, obviating the need to provide surgical biopsy material for this purpose. We conclude that fine‐needle aspiration can identify malignant lymphoid lesions of the lacrimal gland and may serve as a valuable adjunct in the assessment of these lesions. Additional study is warranted to determine whether fine‐needle aspiration can reliably distinguish between benign and malignant lymphoid proliferations of the lacrimal gland. © Wiley‐Liss, Inc.
Growth fraction in non‐Hodgkin's lymphomas and reactive lymphadenitis determined by ki‐67 monoclonal antibody in fine‐needle aspirates
Authors: Linder James , Skoog Lambert , Tani Edneia , Svedmyr Erik , Johansson Bo 
Published: February 2007

AbstractThe fraction of proliferation cells was analysed in fine needle aspirates from a series of 448 non‐Hodgkin's lymphomas and 199 reactive hyperplasias using an immunoperoxidase staining with monoclonal antibody Ki‐67. There was a good correlation between proliferation fraction and cytologic assignment to high and low grade lymphomas. Thus high grade lymphomas had a high median percentage of Ki‐67 positive cells with a figure of 82.1 for lymphoblastic, 60.0 for immunoblastic, and 59.7 for centroblastic lymphomas. For low grade lymphomas the figures were 17.1 and 11.1 percent for centroblastic/centrocytic and CLL/immunocytoma, respectively. the fraction of proliferation cells in reactive lymphadenitis varied between 1–50% with a median of 11.5%. Analysis of Ki‐67 positivity can accordingly not be used to differentiate benign from neoplastic proliferations. Within all lymphoma subgroups but lymphoblastic lymphoma, there was a marked variation in fraction of Ki‐67 positive cells, which resulted in a certain overlap between high and low grade lymphomas. the results show that cells procured through fine‐needle aspiration can be used to analyse the fraction of proliferating cells which contributes information about the growth rate of the individual tumours that can not be obtained through cytologic classification. © Wiley‐Liss, Inc.
Adenomyoepithelioma of the breast: Fine‐needle aspiration biopsy and histologic findings
Authors: Niemann Theodore H. , Benda Jo Ann , Cohen Michael B. 
Published: February 2007

AbstractAdenomyoepithelioma is an uncommon tumor of the breast which clinically presents as a discrete nodule and histologically is composed of lumenal spaces lined by a mixture of epithelial and myoepithelial cells. It has a spectrum of histologic appearances which are gradually gaining wider recognition. There are, however, only a few descriptions of the fine‐needle aspiration biopsy (FNAB) findings in adenomyoepithelioma. We report the FNAB and histologic features of a mammary adenomyoepithelioma which contained a prominent epithelial component including a focus of marked epithelial atypia. This expands the spectrum of FNAB findings which have been reported in adenomyoepithelioma. © Wiley‐Liss, Inc.
Neonatal adenovirus infection: A case report with in situ hybridization confirmation of ascending intrauterine infection
Authors: Montone Kathleen T. , Furth Emma E. , Pietra Giuseppe G. , Gupta Prabodh K. 
Published: February 2007

AbstractAdenovirus infection is a rare, but serious infection, during the neonatal period. the actual mode of infection at birth is currently unknown, however several mechanisms have been proposed. We describe a case of fatal neonatal adenovirus pneumonia in a 25‐wk gestational age infant. Adenovirus was confirmed by electron microscopy and by in situ hybridization. the maternal cervical/endocervical smear taken prior to the delivery contained epithelial cells with changes suggestive of adenovirus, which was confirmed by in situ hybridization on the smear. These findings suggest that ascending viral infection is a factor in the pathogenesis of neonatal adenovirus infection. the identification and reporting of adenovirus may be important during pregnancy in order to avoid delay in delivery of the fetus once membranes have ruptured. © 1995 Willey‐ Liss, Inc.
Molluscum contagiosum presenting as cellulitis in an AIDS patient: Cytologic and ultrastructural features
Authors: Freeman Cathy L. , Moriarty Ann T. 
Published: February 2007

AbstractThis report describes the cytologic features of molluscum contagiosum presenting clinically as a left thigh abscess in a 29‐yr‐old male with AIDS. the fine‐needle aspiration findings are correlated with the histologic and ultrastructural findings. Molluscum contagiosum's clinical presentation, natural course, and induction of host immune responses in immunocompetent and immunosuppressed individuals as identified by light microscopy, immunocytochemically and ultrastructurally are reviewed. Molluscum contagiosum presenting clinically and cytologically as an abscess is unusual. in this report, we emphasize the inclusion of molluscum contagiosum in a differential diagnosis of an abscess, particularly in immunosuppressed patients, and discuss the cytologic differential diagnoses. © 1995 Willey‐ Liss, Inc.