bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly effective decontamination in a hospital environment: An easy‐to‐operate, low‐cost prototype
Authors: de la Rocha Clarice , Caprara Carolina da Silva Canielles , Poester Vanice Rodrigues , Xavier Melissa Orzechowski , Porte Anderson Favero , Galarça Marcelo Moraes , Filgueira Daza de Moraes Vaz Batista , Votto Ana Paula de Souza , Ramos Daniela Fernandes 
Published: April 2024

AbstractHealthcare‐associated infections (HAI) are illnesses acquired during healthcare and are often the most important adverse event during healthcare. With the aim of increasing the effectiveness of disinfection/decontamination processes in the health service with safe and not promote microbial resistance, we propose the development of portable equipment associated with type C ultraviolet light (UVC). The efficiency of the irradiance emitted by the equipment (at dosages 3.5, 5.0, and 60 mJ/cm2) was determined by the action exerted after exposure against four different bacterial (Acinetobacter baumannii, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus) and three different fungi (Candida albicans, C. parapsilosis, and Aspergillus section Fumigati). It was possible to observe that all treatments were capable of inactivating the bacterial species evaluated (p < 0.05), causing the irreversible death of these microorganisms. The most effective elimination of fungal agents was at a dose of 60 mJ/cm2 of UVC radiation, with a decrease in the fungal inoculum varying between 94% and 100% in relation to the control without exposure. Thus, our study showed that the application of the portable prototype with UVC light (254 nm) at a distance of 48 mm, allowed an average irradiance of 3.5 mW/cm2, with doses of 3.5 ≈ 60 mJ/cm2 (from 1 to 60 s of exposure), which can promote the total reduction of the bacteria evaluated and significantly reduce fungal growth. Therefore, this prototype could be used safely and effectively in the hospital environment, considerably reducing contamination and contributing to the reduction of healthcare‐associated infection risk.
Perspectives from the pandemic epicenter: Sexual and reproductive health of immigrant women in New York City
Authors: Samari Goleen , Wurtz Heather M. , Desai Sheila , Coleman‐Minahan Kate 
Published: April 2024

AbstractContextThe United States' response to COVID‐19 created a policy, economic, and healthcare provision environment that had implications for the sexual and reproductive health (SRH) of racialized and minoritized communities. Perspectives from heterogenous immigrant communities in New York City, the pandemic epicenter in the United States (US), provides a glimpse into how restrictive social policy environments shape contraception, abortion, pregnancy preferences, and other aspects of SRH for marginalized immigrant communities.MethodsWe conducted in‐depth interviews in 2020 and 2021 with 44 cisgender immigrant women from different national origins and 19 direct service providers for immigrant communities in New York City to explore how immigrants were forced to adapt their SRH preferences and behaviors to the structural barriers of the COVID‐19 pandemic. We coded and analyzed the interviews using a constant comparative approach.ResultsPandemic‐related fears and structural barriers to healthcare access shaped shifts in contraceptive use and preferences among our participants. Immigrant women weighed their concerns for health and safety and the potential of facing discrimination as part of their contraceptive preferences. Immigrants also described shifts in their pregnancy preferences as rooted in concerns for their health and safety and economic constraints unique to immigrant communities.ConclusionUnderstanding how immigrant women's SRH shifted in response to the structural and policy constraints of the COVID‐19 pandemic can reveal how historically marginalized communities will be impacted by an increasingly restrictive reproductive health and immigration policy landscape.
Experiences of caring after religious disaffiliation: A qualitative study based on the DEW model
Authors: Björkmark Maria , Andtfolk Malin , Nyholm Linda 
Published: April 2024

AbstractBackground and AimLeaving a religious community may occasionally lead to suffering in a human being's life and difficult existential life issues, such as loss of social relationships, identity and well‐being. Only a few studies have been conducted on what kind of care and support human beings who are suffering need in this context. The aim of this study was to increase the understanding of what a human being perceives as caring after religious disaffiliation.MethodsIn‐depth interviews were conducted with 18 participants who had left different religious communities in Finland. The material was analysed through a deductive thematic analysis according to Braun and Clarke, based on the Dressing an existential wound model by Rehnsfeldt and Arman.Results and ConclusionThe results show that what human beings experience as caring after religious disaffiliation is encountering a care professional who understands the needs of someone in this life situation. Based on these needs, caring is described through seven themes.Care professionals need to understand the impact religious disaffiliation may have on clients' lives and respond to their needs. Understanding the suffering of a human being calls for a care professional's holistic view and caring for the whole human being, including spiritual dimensions. This new knowledge can be used by care professionals to develop caring for clients after religious disaffiliation.
Getting a grip on yourself or your environment: Creating opportunities for strategic self‐control in behavioral public policy
Authors: de Ridder Denise 
Published: April 2024

AbstractIn recent years, self‐control research has shifted from a focus on effortful inhibition towards an understanding of self‐control as strategically navigating one's environment by ignoring or avoiding situations that may challenge self‐control. Yet despite increased attention to strategic self‐control, an explicit consideration of perceived control over the environment as a potentially critical driver of self‐control strategies is lacking. Recognizing the crucial role of perceived control, this article reviews research highlighting the interplay between self‐control and control over one's surroundings. We first examine research on new conceptualizations of self‐control that go beyond effortful inhibition of impulses. We then turn to research that addresses the role of perceived control over the environment, arguing that an emphasis on strategic self‐control requires a profound understanding of how perceptions of control determine options for employing self‐control strategies. We conclude with a discussion of promising new directions for behavioral public policies. These policies should better acknowledge the importance of perceived control by creating arrangements that help people in getting more control over their surroundings. This new perspective will take away concerns about an excessive individual frame that holds individuals responsible for self‐control failures in unsupportive environments.
Public sector corruption is fertile ground for conspiracy beliefs: A comparison between 26 Western and non‐Western countries
Authors: Cordonier Laurent , Cafiero Florian 
Published: April 2024

AbstractObjectiveResearch on conspiracy theories has mainly focused on psychosocial and sociodemographic factors associated with conspiracy beliefs. Little is known about factors at the nation level that provide a breeding ground for conspiracist thinking. However, an interesting finding emerges from recent international comparisons: people living in countries with a highly corrupt public sector seem to be more likely to endorse conspiracy theories. The present study aims to replicate this finding with new data.MethodsWe investigate the relationship between corruption and conspiracy beliefs across 26 Western and non‐Western countries through multiple linear regression analyses and conditional inference trees. In addition to the corruption level of these countries, our statistical models include other nation‐level factors known to be associated with the prevalence of conspiracy beliefs, namely, their levels of democracy, freedom of the press, social threat (unemployment and homicide rates), economic inequality, and human development (life expectancy, standard of living, and education).ResultsOur analyses confirm a robust link between public sector corruption and conspiracy beliefs that remains significant when controlling for these other factors.ConclusionWe suggest that public sector corruption is fertile ground for conspiracy theories because it makes them less implausible to the public.
Porcine‐derived collagen peptides promote re‐epithelialisation through activation of integrin signalling
Authors: Mistry Krishan , Richardson Grant , Vleminckx Sara , Smith Robert , Gevaert Elien , Lovat Penny E. 
Published: April 2024

AbstractChronic non‐healing cutaneous wounds represent a major burden to patients and healthcare providers worldwide, emphasising the continued unmet need for credible and efficacious therapeutic approaches for wound healing. We have recently shown the potential for collagen peptides to promote proliferation and migration during cutaneous wound healing. In the present study, we demonstrate that the application of porcine‐derived collagen peptides significantly increases keratinocyte and dermal fibroblast expression of integrin α2β1 and activation of an extracellular signal‐related kinase (ERK)‐focal adhesion kinase (FAK) signalling cascade during wound closure in vitro. SiRNA‐mediated knockdown of integrin β1 impaired porcine‐derived collagen peptide‐induced wound closure and activation of ERK‐FAK signalling in keratinocytes but did not impair ERK or FAK signalling in dermal fibroblasts, implying the activation of differing downstream signalling pathways. Studies in ex vivo human 3D skin equivalents subjected to punch biopsy‐induced wounding confirmed the ability of porcine‐derived collagen peptides to promote wound closure by enhancing re‐epithelialisation. Collectively, these data highlight the translational and clinical potential for porcine‐derived collagen peptides as a viable therapeutic approach to promote re‐epithelialisation of superficial cutaneous wounds.
BRCA
awareness and testing experience in the UK Jewish population: a qualitative study
Authors: Sarig Katrina , Oxley Samuel , Kalra Ashwin , Sobocan Monika , Fierheller Caitlin T , Sideris Michail , Gootzen Tamar , Ferris Michelle , Eeles Rosalind A , Evans D Gareth , Quaife Samantha L , Manchanda Ranjit 
Published: April 2024

Background

1 in 40 UK Jewish individuals carry a pathogenic variant in
BRCA1/BRCA2
. Traditional testing criteria miss half of carriers, and so population genetic testing is being piloted for Jewish people in England. There has been no qualitative research into the factors influencing
BRCA
awareness and testing experience in this group. This study aimed to explore these and inform improvements for the implementation of population genetic testing.

Methods

Qualitative study of UK Jewish adults who have undergone
BRCA
testing. We conducted one-to-one semistructured interviews via telephone or video call using a predefined topic guide, until sufficient information power was reached. Interviews were audio-recorded, transcribed verbatim and interpreted using applied thematic analysis.

Results
32 individuals were interviewed (28 carriers, 4 non-carriers). We interpreted five themes intersecting across six time points of the testing pathway: (1) individual differences regarding personal/family history of cancer, demographics and personal attitudes/approach; (2) healthcare professionals’ support; (3) pathway access and integration; (4) nature of family/partner relationships; and (5) Jewish community factors. Testing was largely triggered by connecting information to a personal/family history of cancer. No participants reported decision regret, although there was huge variation in satisfaction. Suggestions were given around increasing UK Jewish community awareness, making information and support services personally relevant and proactive case management of carriers.

Conclusions

There is a need to improve UK Jewish community
BRCA
awareness and to highlight personal relevance of testing for individuals without a personal/family history of cancer. Traditional testing criteria caused multiple issues regarding test access and experience. Carriers want information and support services tailored to their individual circumstances.
Phenotypic characterisation ofSMAD4variant carriers
Authors: Caillot Claire , Saurin Jean-Christophe , Hervieu Valérie , Faoucher Marie , Reversat Julie , Decullier Evelyne , Poncet Gilles , Bailly Sabine , Giraud Sophie , Dupuis-Girod Sophie 
Published: April 2024

BackgroundBoth hereditary haemorrhagic telangiectasia (HHT) and juvenile polyposis syndrome (JPS) are known to be caused bySMAD4pathogenic variants, with overlapping symptoms for both disorders in some patients. Additional connective tissue disorders have also been reported. Here, we describe carriers ofSMAD4variants followed in an HHT reference centre to further delineate the phenotype.MethodsObservational study based on data collected from the Clinical Investigation for the Rendu-Osler Cohort database.ResultsThirty-three participants from 15 families, out of 1114 patients with HHT, had anSMAD4variant (3%).Regarding HHT, 26 out of 33 participants (88%) had a definite clinical diagnosis based on Curaçao criteria. Complication frequencies were as follows: epistaxis (n=27/33, 82%), cutaneous telangiectases (n=19/33, 58%), pulmonary arteriovenous malformations (n=17/32, 53%), hepatic arteriovenous malformations (AVMs) (n=7/18, 39%), digestive angiodysplasia (n=13/22, 59%). No cerebral AVMs were diagnosed.Regarding juvenile polyposis, 25 out of 31 participants (81%) met the criteria defined by Jasset alfor juvenile polyposis syndrome. Seven patients (21%) had a prophylactic gastrectomy due to an extensive gastric polyposis incompatible with endoscopic follow-up, and four patients (13%) developed a digestive cancer.Regarding connective tissue disorders, 20 (61%) had at least one symptom, and 4 (15%) participants who underwent echocardiography had an aortic dilation.ConclusionWe describe a large cohort ofSMAD4variant carriers in the context of HHT. Digestive complications are frequent, early and diffuse, justifying endoscopy every 2 years. The HHT phenotype, associating pulmonary and hepatic AVMs, warrants systematic screening. Connective tissue disorders broaden the phenotype associated withSMAD4gene variants and justify systematic cardiac ultrasound and skeletal complications screening.
Minimum inhibitory concentrations ofNeisseria gonorrhoeaestrains in clients of the Amsterdam sexual health clinic with a Dutch versus an international sexual network
Authors: Teker Buhari , Schim van der Loeff Maarten , Hoornenborg Elske , Boyd Anders , Reedijk Sophia , van Dam Alje , Jongen Vita Willemijn , de Vries Henry 
Published: April 2024

ObjectivesInternational travel combined with sex may contribute to dissemination of antimicrobial-resistant (AMR)Neisseria gonorrhoeae(Ng). To assess the role of travel in Ng strain susceptibility, we compared minimum inhibitory concentrations (MICs) for five antibiotics (ie, azithromycin, ceftriaxone, cefotaxime, cefixime and ciprofloxacin) in strains from clients with an exclusively Dutch sexual network and clients with an additional international sexual network.MethodsFrom 2013 to 2019, we recorded recent residence of sexual partners of clients (and of their partners) with Ng at the Center for Sexual Health of Amsterdam. We categorised clients as having: (1) exclusively sexual partners residing in the Netherlands (‘Dutch only’) or (2) at least one partner residing outside the Netherlands. We categorised the country of residence of sexual partners by World Bank/EuroVoc regions. We analysed the difference of log-transformed MIC of Ng strains between categories using linear or hurdle regression for each antibiotic.ResultsWe included 3367 gay and bisexual men who had sex with men (GBMSM), 516 women and 525 men who exclusively had sex with women (MSW) with Ng. Compared with GBMSM with a ‘Dutch only’ network, GBMSM with: (1) a Western European network had higher MICs for ceftriaxone (β=0.19, 95% CI=0.08 to 0.29), cefotaxime (β=0.19, 95% CI=0.08 to 0.31) and cefixime (β=0.06, 95% CI=0.001 to 0.11); (2) a Southern European network had a higher MIC for cefixime (β=0.10, 95% CI=0.02 to 0.17); and (3) a sub-Saharan African network had a lower MIC for ciprofloxacin (β=−1.79, 95% CI=−2.84 to −0.74). In women and MSW, higher MICs were found for ceftriaxone in clients with a Latin American and Caribbean network (β=0.26, 95% CI=0.02 to 0.51).ConclusionsFor three cephalosporin antibiotics, we found Ng strains with slightly higher MICs in clients with partner(s) from Europe or Latin America and the Caribbean. International travel might contribute to the spread of Ng with lower susceptibility. More understanding of the emergence of AMR Ng is needed.
Identification of potential candidate genes associated with milk protein differences in Holstein cows: a meta-analysis integrating GWAS and RNA-Seq transcriptome
Authors: Bakhshalizadeh S. , Zerehdaran S. , Hasanpur K. , Javadmanesh A. 
Published: April 2024

Despite the identification of candidate genes influencing milk protein, the connections between genes and regulatory pathways remains elusive. This study aimed integrate findings from genome-wide association studies (GWAS) and RNA sequencing (RNA-Seq) through meta-analysis to pinpoint single nucleotide polymorphisms (SNPs) and genes responsible for high and low protein yield in cows. Previous GWAS and RNA-Seq analyses had identified 663 SNPs and 1106 genes ( P < 0.05). Twenty SNPs from GWAS, 10 genes from RNA-Seq, and 49 SNP/gene associations from both datasets, were identified using meta-analysis. Meta-analysis validated several SNPs previously identified through GWAS, such as rs135549651 ( P = 2.6 × 10−256), rs109146371 ( P = 3.1 × 10−208), rs109350371 ( P = 4.0 × 10−207), and rs109774038 ( P = 8.6 × 10−587). Genes identified in RNA-Seq experiments, including NR4A1 ( P = 3.2 × 10−7), ATF3 ( P = 9.6 × 10−7), CDH16 ( P = 9.9 × 10−7), VEGFA ( P = 1.0 × 10−6), and SAA3 ( P = 7.3 × 10−11), were confirmed. The combined GWAS and RNA-Seq datasets highlighted CCND2 ( P = 8.9 × 10−111), MAPK15 ( P = 1.3 × 10−151), and CPSF1 ( P = 1.2 × 10−306) as the most significant genes. Additionally, significant gene ontology (GO) terms, including ionizing radiation ( P = 1.5 × 10−4), nuclear pore cytoplasmic filaments ( P = 9.4 × 10−5), and phenylalanine 4-monooxygenase activity ( P = 1.4 × 10−5), were identified. In conclusion, the integration of GWAS and RNA-Seq, coupled with GO enrichment, allowed identification of candidate SNPs and genes with higher accuracy. These findings improve our knowledge about genomic architecture of milk protein and enhance evaluation of Holstein cows.
Graph4IUR: Incomplete Utterance Rewriting with Semantic Graph
Authors: Gao Zipeng , Wang Jinke , Xu Tong , Wang Zhefeng , Yang Yu , Su Jia , Chen Enhong 
Published: April 2024

Utterance rewriting aims to identify and supply the omitted information in human conversation, which further enables the downstream task to understand conversations more comprehensively. Recently, sequence edit methods, which leverage the overlap between two sentences, have been widely applied to narrow the search space confronted by the previous linear generation methods. However, these methods ignore the relationship between linguistic elements in the conversation, which reflects how the knowledge and thoughts are organized in human communication. In this case, although most of the content in rewritten sentences can be found in the context, we found that some connecting words expressing relationships are often missing, which results in the out-of-context problem for the previous sentence edit method. To that end, in this paper, we propose a new semantic Graph-based Incomplete Utterance Rewriting (Graph4IUR) framework, which takes the semantic graph to depict the relationship between linguistic elements and captures out-of-context words. Specifically, we adopt the Abstract Meaning Representation (AMR) [4] graph as the basic sentence-to-graph method to depict the dialogue from the graph perspective, which could well represent the high-level semantics relationships of sentences. Along this line, we further adapt the sentence editing models to rewrite without changing the sentence architecture, which brings a restriction to exploring the overlap part of the current and rewritten sentences in the IUR task. Extensive experimental results indicate that our Graph4IUR framework can effectively alleviate the out-of-context problem and improve the performance of the previous edit-based methods in the IUR task.
Jorge O. Caron, um acervo e muitas histórias
Authors: Ruggiero Amanda Saba , Migliati Yasmin Natália 
Published: April 2024

The article tells the story about the personal collection of the architect and professor Jorge Caron, since its formation to its donation to the library of the Institute of Architecture and Urbanism of the University of São Paulo in 2006. It argues about the difficulties and challenges faced in safeguarding, handling and organizing it. The second part of it, relates through the unfolding of the research called: Planning, design, production and assembly of the Exhibition: The trajectory of Jorge Caron, financed by Program of Unified Scholarship (PUB-USP), it was possible to carry out the digitization and partial publication. Throughout these activities, a debate was developed on the role of public universities in the preservation and safeguarding of architects' collections. Other variables were also added, such as the use of digital media for its dissemination, the potential of this nature of collections to encourage new research and historiographical reviews, contemplating the production of knowledge, as well as the incorporation of new collections.
SPECTRA Phase 2b Study: Impact of Sotatercept on Exercise Tolerance and Right Ventricular Function in Pulmonary Arterial Hypertension
Authors: Waxman Aaron B. , Systrom David M. , Manimaran Solaiappan , de Oliveira Pena Janethe , Lu Jonathan , Rischard Franz P. 
Published: April 2024

BACKGROUND:
This study aims to assess the impact of sotatercept on exercise tolerance, exercise capacity, and right ventricular function in pulmonary arterial hypertension.

METHODS:
SPECTRA (Sotatercept Phase 2 Exploratory Clinical Trial in PAH) was a phase 2a, single-arm, open-label, multicenter exploratory study that evaluated the effects of sotatercept by invasive cardiopulmonary exercise testing in participants with pulmonary arterial hypertension and World Health Organization functional class III on combination background therapy. The primary end point was the change in peak oxygen uptake from baseline to week 24. Cardiac magnetic resonance imaging was performed to assess right ventricular function.

RESULTS:

Among the 21 participants completing 24 weeks of treatment, there was a significant improvement from baseline in peak oxygen uptake, with a mean change of 102.74 mL/min ([95% CIs, 27.72–177.76];
P
=0.0097). Sotatercept demonstrated improvements in secondary end points, including resting and peak exercise hemodynamics, and 6-minute walk distance versus baseline measures. Cardiac magnetic resonance imaging showed improvements from baseline at week 24 in right ventricular function.

CONCLUSIONS:
The clinical efficacy and safety of sotatercept demonstrated in the SPECTRA study emphasize the potential of this therapy as a new treatment option for patients with pulmonary arterial hypertension. Improvements in right ventricular structure and function underscore the potential for sotatercept as a disease-modifying agent with reverse-remodeling capabilities.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03738150.