bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphometric similarity differences in drug‐naive Parkinson's disease correlate with transcriptomic signatures
Authors: Wang Yajie , Xiao Yiwen , Xing Yi , Yu Miao , Wang Xiao , Ren Jingru , Liu Weiguo , Zhong Yuan 
Published: March 2024

AbstractBackgroundDifferences in cortical morphology have been reported in individuals with Parkinson's disease (PD). However, the pathophysiological mechanism of transcriptomic vulnerability in local brain regions remains unclear.ObjectiveThis study aimed to characterize the morphometric changes of brain regions in early drug‐naive PD patients and uncover the brain‐wide gene expression correlates.MethodsThe morphometric similarity (MS) network analysis was used to quantify the interregional structural similarity from multiple magnetic resonance imaging anatomical indices measured in each brain region of 170 early drug‐naive PD patients and 123 controls. Then, we applied partial least squares regression to determine the relationship between regional changes in MS and spatial transcriptional signatures from the Allen Human Brain Atlas dataset, and identified the specific genes related to MS differences in PD. We further investigated the biological processes by which the PD‐related genes were enriched and the cellular characterization of these genes.ResultsOur results showed that MS was mainly decreased in cingulate, frontal, and temporal cortical areas and increased in parietal and occipital cortical areas in early drug‐naive PD patients. In addition, genes whose expression patterns were associated with regional MS changes in PD were involved in astrocytes, excitatory, and inhibitory neurons and were functionally enriched in neuron‐specific biological processes related to trans‐synaptic signaling and nervous system development.ConclusionsThese findings advance our understanding of the microscale genetic and cellular mechanisms driving macroscale morphological abnormalities in early drug‐naive PD patients and provide potential targets for future therapeutic trials.
Radiotherapy to the neck after neck dissection for head and neck squamous cell carcinoma from an unknown primary: A narrative review
Authors: Iqbal Muhammad Shahid , Jackson Malcolm , Paterson Claire 
Published: March 2024

AbstractPurposeTo conduct a comprehensive narrative review of the evidence for radiotherapy target volumes to the neck, after neck dissection, for head and neck squamous cell carcinoma from an unknown primary (HNSCCUP). Inclusion or exclusion of mucosal irradiation is not the focus of interest for this review article.Materials and MethodsLiterature (PubMed‐Medline, EMBASE database and Cochrane library) was searched using the relevant keywords. The search results were limited to the studies published in year 2000 or after.ResultsEight studies met the inclusion criteria. All studies were retrospective in nature. The incidence of contralateral recurrence rates in the untreated neck when the involved neck only is treated remains very low (0%–10%). Survival has improved over the past two decades, most likely due to improved diagnostic techniques and the increase in incidence of HPV‐related disease.ConclusionGiven the rarity of disease, level one evidence from randomised controlled trials is lacking. Available data are retrospective but support unilateral post‐operative radiotherapy as a treatment option in selected cases.
A rare case of cutaneous granular cell tumor with unusual Melan‐A expression in a child
Authors: Cheng Nina H. , Smith David , Errickson Carla , Ashi Shaymaa 
Published: March 2024

AbstractGranular cell tumors (GCTs) are rare, indolent neoplasms classically characterized by eosinophilic granular cytoplasm, infiltrations of polygonal cells in the collagenous stroma, and pustulo‐ovoid bodies of Milian. We describe a case of a 10‐year‐old female presenting with a GCT of the upper arm, remarkable for positive Melan‐A expression without additional melanocytic features. The differentiation between granular cells versus melanocytic neoplasms carries significant implications for clinical management, and such diagnoses should be considered carefully in the setting of unusual immunophenotypes.
Predicting mean and variance in inventory order decisions
Authors: Chen Li , Davis Andrew M. , Kim Dayoung 
Published: March 2024

AbstractWe develop a simple forecast‐anchoring model to explain and predict the mean and variance of observed inventory order decisions in a newsvendor problem. The model assumes that people employ a two‐step decision heuristic. In the first step, a behavioral bias may gravitate the decision maker's point forecast toward a random forecast versus a constant unbiased forecast. In the second step, a behavioral bias of the same magnitude may cause the decision maker to treat the point forecast as if it is the mean of potential demand, and then make an upward or downward adjustment depending on the underage and overage costs. We evaluate the performance of this descriptive forecast‐anchoring model across five experimental newsvendor data sets. First, we fit the model to a setting with uniform demand. We then use the corresponding estimates to generate predictions in a secondary data set with uniform demand, as an out‐of‐sample test. We proceed to fit the model to three additional newsvendor data sets, two with normal demand and one with asymmetric two‐point demand. In all cases, the model predicts the mean and variance of inventory order decisions well. We further investigate the profit implications under the forecast‐anchoring model and find that the predictions match well with the experimental data. Through improved predictions, the model can help upstream supply chain parties anticipate inventory order decisions from buyers and improve profitability.
The effect of glucagon‐like peptide‐1 receptor agonists on cardiac function and structure in patients with or without type 2 diabetes mellitus: An updated systematic review and meta‐analysis
Authors: Zhang Yu , Yang Danning , Jia Qiufeng , Yan Jie , An Fengshuang 
Published: March 2024

AbstractAimsTo conduct an updated systematic review and meta‐analysis to evaluate the efficacy of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) with regard to cardiac function and structure in people with or without type 2 diabetes mellitus (T2DM).Materials and MethodsWe conducted a systematic search using the PubMed, Embase and ClinicalTrials.gov online databases. The primary outcome of interest was changes in mitral inflow E‐velocity to tissue Doppler e' velocity (E/e') ratio. Secondary outcomes included other indicators of cardiac reverse remodelling and functional capacity comprising changes in left ventricular mass (LVM), left ventricular global longitudinal strain, left ventricular end‐diastolic volume, left ventricular end‐systolic volume, left ventricular ejection fraction (LVEF), early to atrial mitral inflow velocity ratio, left atrial volume (LAV), N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) levels and 6‐min walk test (6MWT) results.ResultsA total of 15 trials involving 898 patients were included in this analysis. GLP‐1RAs significantly improved E/e' ratio (mean difference [MD] = −0.73; 95% confidence interval [CI] −1.34, −0.13), LVM (MD = −3.86 g; 95% CI −7.60, −0.12), LAV (MD = −8.20 mL; 95% CI −12.37, −4.04), NT‐proBNP level (standardized MD = −0.27; 95% CI −0.47, −0.06), and 6MWT result (MD = +22.31 m; 95% CI 1.64, 42.99). However, GLP‐1RAs had no effect on LVEF (MD = +0.31%; 95% CI −1.02, 1.64).ConclusionsIn this systematic review and meta‐analysis, GLP‐1RAs were found to have a positive impact on left ventricle diastolic function, hypertrophy, and exercise capacity, but had no effect on systolic function.
Mitophagy modulation for the treatment of cardiovascular diseases
Authors: Forte Maurizio , D'Ambrosio Luca , Schiattarella Gabriele G. , Salerno Nadia , Perrone Marco Alfonso , Loffredo Francesco S. , Bertero Edoardo , Pilichou Kalliopi , Manno Girolamo , Valenti Valentina , Spadafora Luigi , Bernardi Marco , Simeone Beatrice , Sarto Gianmarco , Frati Giacomo , Perrino Cinzia , Sciarretta Sebastiano ,   the Italian Society of Cardiology Working Group on Cellular and Molecular Biology of the Heart
Published: March 2024

AbstractBackgroundDefects of mitophagy, the selective form of autophagy for mitochondria, are commonly observed in several cardiovascular diseases and represent the main cause of mitochondrial dysfunction. For this reason, mitophagy has emerged as a novel and potential therapeutic target.MethodsIn this review, we discuss current evidence about the biological significance of mitophagy in relevant preclinical models of cardiac and vascular diseases, such as heart failure, ischemia/reperfusion injury, metabolic cardiomyopathy and atherosclerosis.ResultsMultiple studies have shown that cardiac and vascular mitophagy is an adaptive mechanism in response to stress, contributing to cardiovascular homeostasis. Mitophagy defects lead to cell death, ultimately impairing cardiac and vascular function, whereas restoration of mitophagy by specific compounds delays disease progression.ConclusionsDespite previous efforts, the molecular mechanisms underlying mitophagy activation in response to stress are not fully characterized. A comprehensive understanding of different forms of mitophagy active in the cardiovascular system is extremely important for the development of new drugs targeting this process. Human studies evaluating mitophagy abnormalities in patients at high cardiovascular risk also represent a future challenge.
What do fish do after passing through a fishway? A radio‐telemetry study on patrimonial holobiotic species
Authors: Gelder Justine , Benitez Jean‐Philippe , Ovidio Michaël 
Published: March 2024

AbstractThe restoration of longitudinal connectivity in rivers allows fish to colonise new habitats. However, there is a lack of information regarding the behaviour of fish when they colonise the newly opened river stretch. We used manual radiotelemetry to tracked individuals belonging to four species (trout, nase, grayling and barbel) after their release upstream of two obstacles in the Amblève River. We observed a diversity of movement behaviours and habitats used among the studied species. All the species used potential spawning habitats with distances travelled upstream reaching 2.4 km for the grayling, 7.0 km for the barbel, 16.9 km for the nase and 18.0 km for the trout, which also use tributaries and sub‐tributaries of the Amblève River. Post‐reproduction downstream behaviours were observed in all species, but this was made difficult by the absence of downstream migration devices at dams that forced fish to seek alternative habitats. Our study suggested that allowing fish to move upstream with fishways is beneficial as the species succeeded in reaching spawning grounds, but a holistic approach combined with the installations of devices or an opening of gates to allow post‐reproduction downstream migrations would allow them to completely accomplish their biological cycle.
AXCF: Aspect‐based collaborative filtering for explainable recommendations
Authors: Kim Dongeon , Li Qinglong , Jang Dongsoo , Kim Jaekyeong 
Published: March 2024

AbstractWith the rapid growth of the e‐commerce market facilitated, users are often overwhelmed by the excessive online information, making item selection challenging. While recommendation services have significantly enhanced user experience and sales, these traditional models often overlook the complexity of user‐item interactions and user preferences based on various item aspects. The proposed AXCF framework innovatively combines graph‐based collaborative filtering (CF), which captures high‐order connectivity between users and items, with aspect‐based sentiment analysis (ABSA) to extract detailed user preferences from online reviews. This approach addresses the limitations of linear relationships in traditional CF models by incorporating deep neural networks and introduces a method to overcome the cold‐start problem using online reviews as auxiliary information. By focusing on main aspects such as food, ambiance, and service derived from restaurant reviews, AXCF provides personalized recommendations with improved accuracy and explanatory power, demonstrating its superiority over existing models through experimental results. This study not only presents a significant advancement in recommender systems but also highlights the importance of high‐order connectivity and aspect‐based preferences in understanding and catering to user needs in the e‐commerce platform.
Associations between measured masticatory function and cognitive status: A systematic review
Authors: Maekawa Kenji , Motohashi Yoshiko , Igarashi Kentaro , Mino Takuya , Kawai Yasuhiko , Kang Youngnam , Hirai Toshihiro , Kuboki Takuo 
Published: March 2024

ObjectiveThis systematic review aimed to provide an overview of the most recent evidence on the association between measured masticatory function and cognitive status.Materials and MethodsLiterature and manual searches were conducted using three electronic databases (PubMed, Web of Science and CINAHL). Observational studies published between 2011 and 2021 investigating the association between masticatory function, dementia and cognitive status in adult humans were abstracted and reviewed by three reviewers. Studies that assessed participants' masticatory function using objective and subjective measurements and that individually examined its association with cognitive function were included. The included studies were divided into cross‐sectional and cohort studies, and the quality of each study was analysed using critical appraisal skills checklists. Additionally, the main conclusions and strength of the evidence were assessed for each article.ResultsA total of 21 studies (11 cross‐sectional studies that objectively evaluated masticatory function, 9 cross‐sectional studies that subjectively evaluated masticatory function and 1 prospective cohort study) were evaluated. The poorer masticatory function was associated with lower cognitive status even after adjusting for potential risk factors of dementia in four of 11 and six of nine cross‐sectional studies where the masticatory function was respectively evaluated objectively and subjectively. One prospective cohort study also demonstrated that masticatory function, as evaluated based on measurements of occlusal force, predicted cognitive decline during the follow‐up period.ConclusionSeveral studies demonstrated a positive association between masticatory function and cognitive status. However, further studies, particularly longitudinal studies, are required to determine whether the association is causal.
X‐Ray Fluorescence Determination of FeII/Fetotal Ratios in Sediments and Soils
Authors: Pleßow Alexander , Mehne Marcel , Kureti Sven 
Published: March 2024

The two most common oxidation states of iron can be determined by wavelength‐dispersive X‐ray fluorescence spectrometry relatively fast with an accuracy comparable to that of alternative methods. Main advantages for the analysis of sediments and soils are that organic matter does not interfere and solid samples can be analysed directly with minimal preparation effort. The limited availability of appropriate reference materials with certified data on their ferrous iron content turned out to be the major obstacle to implementing the method. For this reason and because no influence of the analysed geological materials on the intensity ratios of the closely adjacent Fe Kβ5 / Fe Kβ1,3 lines became evident, several rock types were selected in addition to sediments and soils to broaden and improve the calibration. Nevertheless, most reference data for calibration had to be determined by 57Fe Mössbauer spectroscopy. Plotting Fe Kβ5/Fe Kβ1,3 intensity ratios versus w FeO/w Fe2O3total ratios resulted in a correlation with R2 = 0.962 for the linear regression of all calibration data.
Middle‐aged migrants: Expanding an understanding of lifecourses and linked lives
Authors: Lulle Aija 
Published: March 2024

AbstractThis paper explores a new perspective on middle‐aged migrant women. Midlife has long been presumed to be the most networked stage of life for sedentary populations, but it has not been examined critically in the context of migration. This is an empty space that warrants research attention, because middle‐aged migrants often have lives that are temporally and spatially distinctive. Drawing on ethnographic fieldwork in Latvia and the United Kingdom (2018–2023), I argue that the lifecourses of middle‐aged migrant women resemble the transitions that young people go through for work but differ in terms of care. Although strong ties relatives and friends have long been thought to be key for transnational care relations, weak ties also become instrumental through shared notions of self‐actualization in midlife. I provide a novel understanding of how the concepts of linked lives and networks can be applied to processes that are pertinent to middle‐aged women.
Changes in brain proteasome dynamics associated with aging
Authors: Nago Nodoka , Murata Shigeo , Tanaka Keiji , Tanahashi Nobuyuki 
Published: March 2024

AbstractIn the nervous system, proteasomes are important for proteolysis and cellular homeostasis of neurons and glial cells and for brain health. Proteasome function declines with age in many tissues, including the nervous system, and this decline affects many of the nervous system processes important to brain health and may be related to age‐related cognitive decline. Therefore, we analyzed the factors that contribute to this decline in function using the brain of mice from different months of life. Peptidase activity of proteasomes in crude extracts decreased with aging, while ubiquitinated proteins increased with aging. Additionally, there was a tendency for the number of subunits that form proteasomes to decrease slightly with age. On the other hand, ump1, which is required for proteasome formation, accumulated with age. Therefore, analysis of proteasome dynamics in each month revealed that proteasome formation decreased with aging. This study suggests that with aging, not only 20S proteasome function but also 26 proteasome function decreases, the decline in proteasome function is due to the lack of proteasome formation, the PA28‐20S‐PA700 complex, which is involved in immunity, increases in the brain, and one factor in this lack of proteasome formation is that the proteins called UMP1.
Current and emerging gene therapies for haemophilia A and B
Authors: Kaczmarek Radoslaw , Miesbach Wolfgang , Ozelo Margareth C. , Chowdary Pratima 
Published: March 2024

AbstractIntroductionAfter decades of stumbling clinical development, the first gene therapies for haemophilia A and B have been commercialized and have normalized factor (F)VIII and factor (F)IX levels in some individuals in the long term. Several other clinical programs testing adeno‐associated viral (AAV) vector gene therapy are at various stages of clinical testing.DiscussionMultiyear follow‐up in phase 1/2 and 3 studies showed long‐term and sometimes curative but widely variable and unpredictable efficacy. Liver toxicities, mostly low‐grade, occur in the 1st year in at least some individuals in all haemophilia A and B trials and are poorly understood. Wide variability and unpredictability of outcome and slow decline of FVIII levels are a major disadvantage because immune responses to AAV vectors preclude repeat dosing, which otherwise could improve suboptimal or restore declining expression, while overexpression may predispose to thrombosis. Long‐term safety outcomes will need lifelong monitoring because AAV vectors infused at high doses integrate into chromosomes at rates that raise questions about potential oncogenicity and necessitate vigilance. Alternative gene transfer systems employing gene editing and/or non‐viral vectors are under development and promise to overcome some limitations of the current state of the art for both haemophilia A and B.ConclusionsAAV gene therapies for haemophilia have now become new treatment options but not universal cures. AAV is a powerful but imperfect gene transfer platform. Biobetter FVIII transgenes may help solve some problems plaguing gene therapy for haemophilia A. Addressing variability and unpredictability of efficacy, and delivery of gene therapy to ineligible patient subgroups may require different gene transfer systems, most of which are not ready for clinical translation yet but bring innovations needed to overcome the current limitations of gene therapy.
Laboratory workflow for optimizing leukocyte count and differential in synovial fluids on Sysmex XN‐1000
Authors: Vanrenterghem Marthe , Dom Julie , Boeckx Nancy , Depypere Melissa , Frans Glynis , Vles Georges , Van Laer Christine 
Published: March 2024

AbstractIntroductionFalsely elevated synovial white blood cell (WBC) counts using automated hematology analyzers have been reported particularly in the setting of joint arthroplasty. We evaluated the implementation of a laboratory workflow based on Sysmex XN‐1000‐automated cell counting and scattergram interpretation.MethodsWBC and differential were measured for 76 synovial fluid samples (29 native joints and 47 with joint arthroplasties) with Sysmex XN‐1000 and manual methods. All scattergrams were evaluated for possible incorrect WBC and/or differential according to our implemented workflow. A specific finding was the “banana‐shape” scattergram, which indicates possible interferences. The European Bone & Joint Infection Society (EBJIS) criteria were applied to identify possible prosthetic joint infections (PJIs) in patients with joint arthroplasties.ResultsCorrelation between automated and manual WBC counts, calculated for samples with WBC count <50 000/μL, was higher for native joints (r = 0.938) compared with patients known with arthroplasty (r = 0.906). Scattergrams classified as OK showed overall a higher correlation compared with scattergrams, which were interpreted as NOT OK. “Banana‐shape” scattergrams (n = 19) showed falsely elevated automated WBC count, and the patterns were mainly seen in prosthesis patients (17/19 [89%]). Six of 47 (13%) patients with joint arthroplasties were reclassified from “confirmed” to “unlikely” PJI according to the EBJIS criteria.ConclusionOur workflow based on scattergram interpretation resulted in accurate WBC counts in synovial fluid using automated/and or manual methods. It is important to identify the presence of “banana‐shape” scattergrams to avoid overestimated automated WBC counts. Overall, automated synovial WBC count can be used, even for patients with arthroplasty, but after visual inspection of the scattergram to exclude possible interferences.