bluuebunny/crossref_metadata_2025_split huggingface dataset:
Substitution at the α‐Carbons of α,β‐Unsaturated Carbonyl Compounds: anti‐Michael Addition.
Authors: Lewandowska Elzbieta 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Properties of Size‐Expanded DNAs: Toward Designed, Functional Genetic Systems
Authors: Krueger Andrew T. , Lu Haige , Lee Alex H. F. , Kool Eric T. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemistry of the Hexahydropyrrolo[2,3‐b]indoles: Configuration, Conformation, Reactivity, and Applications in Synthesis
Authors: Crich David , Banerjee Abhisek 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Solvothermal in situ Metal/Ligand Reactions: A New Bridge Between Coordination Chemistry and Organic Synthetic Chemistry
Authors: Chen Xiao‐Ming , Tong Ming‐Liang 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Efficient Synthesis of Heterocyclic Compounds Based on Reactivity of Trifluoroacetyl Group
Authors: Miyata Okiko , Takeda Norihiko , Naito Takeaki 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Marine Natural Products
Authors: Blunt John W. , Copp Brent R. , Hu Wan‐Ping , Munro Murray H. G. , Northcote Peter T. , Prinsep Michele R. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Bisintercalator Natural Products with Potential Therapeutic Applications: Isolation, Structure Determination, Synthetic and Biological Studies
Authors: Dawson Simon , Malkinson John P. , Paumier David , Searcey Mark 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Structures of RNA Switches: Insight into Molecular Recognition and Tertiary Structure
Authors: Schwalbe Harald , Buck Janina , Fuertig Boris , Noeske Jonas , Woehnert Jens 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Identification and Expression Regulation of Symbiotically Activated Legume Genes
Authors: Kuester Helge , Vieweg Martin F. , Manthey Katja , Baier Markus C. , Hohnjec Natalija , Perlick Andreas M. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Plant Signals and Fungal Perception During Arbuscular Mycorrhiza Establishment
Authors: Requena Natalia , Serrano Esther , Ocon Aurora , Breuninger Magdalene 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ratiometric and Near‐Infrared Molecular Probes for the Detection and Imaging of Zinc Ions
Authors: Carol Priya , Sreejith Sivaramapanicker , Ajayaghosh Ayyappanpillai 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Progress in the Studies of Oxidation of Dihydropyridines and Their Analogues
Authors: Matern A. I. , Charushin V. N. , Chupakhin O. N. 
Published: May 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rational Design, Synthesis, and Evaluation of Nanomolar Type II Dehydroquinase Inhibitors
Authors: Payne Richard J. , Peyrot Fabienne , Kerbarh Olivier , Abell Andrew D. , Abell Chris 
Published: May 2007

AbstractThe in silico design, synthesis, and biological evaluation of ten potent type II dehydroquinase inhibitors are described. These compounds contain an anhydroquinate core, incorporated as a mimic of the enolate reaction intermediate. This substructure is attached by a variety of linking units to a terminal phenyl group that binds in an adjacent pocket. Inhibitors were synthesised from (−)‐quinic acid using palladium‐catalysed Stille and carboamidation chemistry. Several inhibitors exhibited nanomolar inhibition constants against type II dehydroquinases from Streptomyces coelicolor and Mycobacterium tuberculosis. These are among the most potent inhibitors of these enzymes reported to date.
The quality of surgical pathology care for men undergoing radical prostatectomy in the U.S.
Authors: Miller David C. , Spencer Benjamin A. , Shah Rajal B. , Ritchey Jamie , Stewart Andrew K. , Gay E. Greer , Dunn Rodney L. , Wei John T. , Litwin Mark S. 
Published: May 2007

AbstractBACKGROUND.The authors assessed adherence with the College of American Pathologists (CAP) radical prostatectomy (RP) practice protocol in a national sample of men who underwent RP for early‐stage prostate cancer.METHODS.Using the National Cancer Data Base, the authors identified a nationally representative sample of 1240 men (unweighted) who underwent RP. For each patient, local cancer registrars performed an explicit medical record review to assess patient‐level compliance with surgical pathology report documentation of 7 morphologic criteria (ie, quality indicators). Applying the CAP prognostic factor classification framework, composite measures and all‐or‐none measures of quality indicator compliance were calculated for the following analytic categories: 1) a strict subset of CAP category I prognostic factors (3 indicators), 2) a broad subset of CAP category I factors (6 indicators), and 3) the full set of 7 indicators.RESULTS.Among a weighted sample of 24,420 patients who underwent RP, compliance with documentation of the CAP category I factors varied from 54% (95% confidence interval [95% CI], 50–58%) for pathologic tumor, lymph node, metastases classification (according to the American Joint Committee on Cancer staging system) to 97% (95% CI, 96–99%) for Gleason score. In composite, RP pathology reports contained 83% (95% CI, 81–84%), 85% (95% CI, 84–87%), and 79% (95% CI, 78–80%) of the recommended data elements measured by the strict CAP category I subset, the broad CAP category I subset, and the full set of 7 indicators, respectively. In contrast to the generally higher composite scores, only 52% (95% CI, 48–56%) and 41% (95% CI, 37–45%) of men who underwent RP had complete documentation in their pathology reports for the strict and broad CAP category I subsets, respectively.CONCLUSIONS.RP surgical pathology reports contained most of the recommended data elements; however, the frequent absence of pathologic stage provides an opportunity for quality improvement. Cancer 2007. © 2007 American Cancer Society.
p53 codon 72 polymorphisms in human papillomavirus‐negative and human papillomavirus‐positive squamous cell carcinomas of the oropharynx
Authors: Perrone Federica , Mariani Luigi , Pastore Elisa , Orsenigo Marta , Suardi Simona , Marcomini Barbara , DaRiva Luca , Licitra Lisa , Carbone Antonino , Pierotti Marco A. , Pilotti Silvana 
Published: May 2007

AbstractBACKGROUND.Tobacco smoking, alcohol abuse, and high‐risk human papillomavirus (HPV) are risk factors in the etiology of oropharyngeal squamous cell carcinomas (SCCs). The TP53 polymorphism, in which an arginine (R) is changed to proline (P) at codon 72, is functionally significant and could therefore be a predisposing genetic defect.METHODS.The aim of the study was to investigate the role of codon 72 polymorphism by means of double gradient‐denaturing gel electrophoresis in 77 oropharyngeal SCC patients including 33 TP53 mutated and 16 HPV‐16‐positive cases. The controls consisted of 141 consecutive healthy blood donors.RESULTS.The cases and controls showed significantly different genotype distribution (P = .0005): the frequencies of the RR, RP, and PP genotypes among the cases were, respectively, 81.8%, 10.4%, and 7.8%, as opposed to 59.6%, 33.3%, and 7.1% among the controls, in agreement with the Hardy‐Weinberg equilibrium (P = .35). The PP genotype was significantly overrepresented among females (22.2% vs 3.4%; P = .0243) and in HPV‐16‐positive cases (25.0% vs 3.3%; P = .0152). No segregation was found between either of the codon 72 genotypes and age or TP53 mutations.CONCLUSIONS.The significantly lower frequency of the RP genotype in the patients as a whole suggests that it has a protective effect on oropharyngeal SCCs. Moreover, the PP genotype may be a risk factor for the development of oropharyngeal SCC by females and the development of HPV‐16‐related SCC, although the findings need to be validated in a larger number of tumors. Cancer 2007. © 2007 American Cancer Society.
New measure of health‐related quality of life for patients with oropharyngeal mucositis
Authors: Cheng Karis K. F. , Leung S. F. , Thompson David R. , Tai Josepha W. M. , Liang Raymond H. S. , Kan Alta S. T. , Ying Fion W. O. , Yeung Rebecca M. W. 
Published: May 2007

AbstractBACKGROUND.Oropharyngeal mucositis (OM) causes profound impairment of patients' health‐related quality of life (HQoL). The aim of the article is to describe the development and preliminary validation of an HQoL instrument, OMQoL, specifically for patients with OM.METHODS.First, a qualitative phase was conducted to generate items (n = 23). Face validity was assessed by focus group interviews (n = 13). Expert content review (n = 7) was used to ensure content validity. The second step was a quantitative validation phase comprised a multicenter study (n = 210) to help identify subscales of the instrument addressing different dimensions of OM and to measure reliability.RESULTS.The qualitative interview generated 171 items. Using focus group discussion and expert content review, items were reduced to 41 items. Factor and scaling analyses of these 41 items resulted in 4 subscales, contributed by 31 items, depicting problems with symptoms, diet, social function, and swallowing. The floor effect was modest. The factorial structure was satisfactory with loading >0.40 on each subscale for all items. All corrected item‐total corrections were higher than 0.40 (r = 0.457–0.874). The internal consistency reliability of each subscale was high, with Cronbach alpha coefficients ranging from 0.906 to 0.934. The test‐retest reliability of the individual items using weighted kappa was good (kappa values 0.610–0.895). The intraclass correlation results for the subscale totals were all in excess of 0.70 (0.864–0.934).CONCLUSIONS.An initial psychometric analysis of the OMQoL was encouraging. The OMQoL could provide a valuable tool for the assessment of HQoL of patients with OM. Cancer 2007. © 2007 American Cancer Society.
Cdk5 selectively affects the migration of different populations of neurons in the developing spinal cord
Authors: Yip Yee Ping , Capriotti Christine , Drill Emily , Tsai Li‐Huei , Yip Joseph W. 
Published: May 2007

AbstractIt has been shown that cyclin‐dependent kinase 5 (Cdk5) is crucial for neuronal migration and survival in the brain. However, the role of Cdk5 in neuronal migration in the spinal cord has never been investigated. The present study is the first to show that Cdk5 affects the migration of different populations of neurons in the developing spinal cord. In the absence of Cdk5, at least four neuronal populations failed to migrate to their final destinations: sympathetic and parasympathetic preganglionic neurons, as well as dorsally originating and ventrally originating (U‐shaped group) diaphorase‐positive dorsal horn interneurons. In contrast, the migration of somatic motor neurons and various types of ventral and dorsal interneurons was unaffected by the absence of Cdk5. Moreover, our results suggest that Cdk5‐dependent migration in the developing spinal cord is axon‐ or glial fiber‐mediated. Finally, our results show that sympathetic preganglionic neurons and somatic motor neurons in Cdk5‐deficient mice continue to extend processes and project toward their normal target areas, suggesting that Cdk5 has no obvious effects on axonal outgrowth and guidance mechanisms of these two neuronal populations in spinal cord development. J. Comp. Neurol. 503:297–307, 2007. © 2007 Wiley‐Liss, Inc.
Neurochemical characterization of insulin receptor‐expressing primary sensory neurons in wild‐type and vanilloid type 1 transient receptor potential receptor knockout mice
Authors: Baiou Djalil , Santha Peter , Avelino Antonio , Charrua Ana , Bacskai Timea , Matesz Klara , Cruz Francisco , Nagy Istvan 
Published: May 2007

AbstractThe insulin receptor (IR) is expressed by a subpopulation of primary sensory neurons (PSN), including a proportion of cells expressing the nociceptive transducer vanilloid type 1 transient receptor potential receptor (TRPV1). Recent data suggest functional links between the IR and other receptors, including TRPV1, which could be involved in the development of PSN malfunctions in pathological insulin secretion. Here we used combined immunohistochemical labelling on sections from L4–5 dorsal root ganglia of wild‐type (WT) and TRPV1 knockout (KO) mice to examine the neurochemical properties of IR‐expressing PSN and the possible effect of deletion of TRPV1 on those characteristics. We found that antibodies raised against the high‐molecular‐weight neurofilament (NF‐200) and the neurofilament protein peripherin distinguished between small and large neurons. We also found that the IR was expressed predominantly by the small peripherin‐immunopositive cells both in the WT and in the KO animals. IR expression, however, did not show any preference between the major subpopulations of the small cells, the calcitonin gene‐related peptide (CGRP)‐expressing and Bandeiraea simplicifolia isolectin B4 (IB4)‐binding neurons, either in the WT or in the KO mice. Nevertheless, a significant proportion of the IR‐expressing cells also expressed TRPV1. Comparison of the staining pattern of these markers showed no difference between WT and KO animals. These findings indicate that the majority of the IR‐expressing PSN are small neurons, which are considered as nociceptive cells. Furthermore, these data show that deletion of the TRPV1 gene does not induce any additional changes in neurochemical phenotype of nociceptive PSN. J. Comp. Neurol. 503:334–347, 2007. © 2007 Wiley‐Liss, Inc.
On the Nature of the Surprisingly Small (Red) Shift in the Halothane⋅⋅⋅Acetone Complex
Authors: Pluháčková Kristýna , Hobza Pavel 
Published: May 2007

AbstractThe halothane⋅⋅⋅acetone and fluoroform⋅⋅⋅acetone complexes are studied using the second‐order Møller–Plesset (MP2) method with a cc‐pVTZ basis set and the density functional theory (DFT) method with a TZVP basis set. Whereas halothane exhibits a small red shift upon complexation, fluoroform shows a pronounced blue shift. To explain this difference in behavior, we perform symmetry‐adapted perturbation theory (SAPT) and natural bond orbital (NBO) analyses. Although the composition of the total stabilization energy of each complex is different, that alone does not provide a satisfactory explanation for the difference in the spectral shifts. This difference is interpreted as a result of the interplay of the hyperconjugation and rehybridization mechanisms. The small and surprising red shift of the CH stretching frequency of halothane, which resulted from the complexation of this species with acetone,is explained by the compensation of the two above‐mentioned mechanisms. On the other hand, the fluoroform⋅⋅⋅acetone complex exhibits a blue shift of the CH stretching frequency upon complexation, the most likely reason for this shift being a concerted occurrence of the hyperconjugation and rehybridization mechanisms. The calculated shift of the CH stretching vibration frequencies of halothane (+27 cm−1) agree with the experimental value of +5 cm−1.
Doping‐induced‐effects on conduction mechanisms in incommensurate ammonium zinc chloride crystals
Authors: Gaffar M. A. , Abu El‐Fadl A. , Bin Anooz S. 
Published: May 2007

AbstractThe dc conductivity (σ) along the polar b‐axis of ammonium zinc chloride (AZC) crystals in its four high‐temperature phases has been measured as a function of temperature. Doping with Mn2+ in different concentrations changed strongly both values of σ at all temperatures and the dependence of ln σdc on 1/T in the phase transition regions. The activation energy of conduction was calculated from the linear portions of this dependence in each phase. The results were discussed in the light of the decomposition of (NH4)2 in the high‐temperature normal phase, the discommensuaration (DC) formation/annihilation in the incommensurate phase and domain wall motion and stripples nucleation in the commensurate‐ and antiferroelectric‐phases. Pinning of DC's in the crystal lattice and/or by the structural defects and the possibility of dislocation formation was also discussed. The bulk‐ and the electrode‐limited conduction mechanisms were also considered. The current density‐voltage gradient relationship according to the usual Richardson‐Schottky (R‐S) equation shows disagreement between extracted parameters and experimentally measured ones. A modified equation was used to solve this difficulty which, in addition, facilitated the calculation of the electronic mobility (μ), the barrier height (φ) at the electrode‐dielectric interface and the R‐S constant (βRS). The effect of Mn2+‐content on values of μ, φ and βRS in different phases of AZC was also considered. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Studies on large uniaxially grown benzophenone single crystals
Authors: Arivanandhan M. , Sankaranarayanan K. , Ramasamy P. 
Published: May 2007

Abstract〈110〉, 〈010〉 and 〈100〉 oriented uniaxial benzophenone crystals were grown by uniaxially solution‐crystallization method of Sankaranarayanan ‐ Ramasamy (SR). The experimental parameters involved in the present study were investigated in detail and a constant growth rate was achieved by compensating the loss of growth units in the solution. A transparent uniaxial benzophenone crystal having dimension of 500 mm length and 55 mm diameter was grown at room temperature for the first time in the literature. In contrast to the conventional solution growth method, the growth rate along each direction was measured at ease during the respective growth experiment by monitoring the elevation of the solid‐liquid interface and found to be 2, 4 and 6 mm/day along the 〈110〉, 〈010〉 and 〈100〉 directions respectively for a chosen supersaturation. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Synthesis and characterization of cadmium tartrate single crystals
Authors: Arora S. K. , Kothari A. , Amin B. , Chudasama B. 
Published: May 2007

AbstractEfforts have been successful to crystallize the electroceramic compound of cadmium tartrate through silica hydrogel. Analysis of thermograms reveals decomposition of the crystals to take place within the temperature range 65 to 442°C in air atmosphere. Some important characteristic data, i.e., valance electron plasma energy, Penn gap, Fermi energy, interionic distance, electronic polarizability have been obtained. The DC conductivity of the crystal typically lies between the conductivities of metal and insulator and we derived several pertinent parameters such as hopping energy, hopping distance, coulomb gap, etc. The micromechanical indentation of the crystal shows nonlinear variation of the impact microhardness as a function of the applied load. The estimation of fracture toughness, fragility coefficient and yield strength has too been made for the synthesized crystal. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Growth and characterization of doped hippuric acid crystals for NLO devices
Authors: Suresh Kumar B. , Rajendra Babu K. 
Published: May 2007

AbstractModified hippuric acid (HA) single crystals have been grown from aqueous solution of acetone by doping with NaCl and KCl using slow evaporation technique at constant temperature, with the vision to improve the physicochemical properties of the sample. The characterisation of grown crystals was made by X‐ray powder diffraction, density and melting point measurements. TGA/DTA studies indicate that doped crystals are more stable than pure crystals. The optical transmission study and Kurtz powder SHG measurement shows the suitability of doped crystals for NLO applications. Dopant concentration is identified with ICP atomic emission spectrometer system. The Vicker's hardness studies at room temperature, carried out on (111) crystallographic plane shows increased hardness of the doped crystals. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Estimation of spontaneous antipolarization of ADP based on magnitude of fourth‐order electrooptic effect
Authors: Górski P. , Ledzion R. , Kucharczyk W. 
Published: May 2007

AbstractApplying the relationship between the spontaneous birefringence of ADP appearing in the low‐temperature antiferroelectric phase with the spontaneous antipolarization, and taking into consideration the known experimental values for the quadratic and fourth‐order electrooptic effects, an estimate is made of the lower limit of the spontaneous antipolarization. The estimation, which employs the fourth‐order electrooptic effect, gives the antipolarization P = 1.2 · 10‐2 Cm‐2, a value comparable in magnitude to the spontaneous polarization observed in ferroelectrics belonging to the KDP family of crystals. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Specific features of the optical spectra in Tl2In2S3Se layered single crystals
Authors: Gasanly N. M. , Guler I. , Goksen K. 
Published: May 2007

AbstractThe optical properties of Tl2In2S3Se layered single crystals have been studied by means of transmission and reflection measurements in the wavelength range of 450‐1100 nm. The analysis of the absorption data revealed the presence of both optical indirect and direct transitions with energy band gaps of 2.16 and 2.42 eV, respectively. The observed coexistence of indirect and direct energy band gaps is related to the anisotropy of the Tl‐containing layered crystals. The dispersion of the refractive index is discussed in terms of the Wemple‐DiDomenico single‐effective‐oscillator model. The refractive index dispersion parameters: oscillator energy, dispersion energy, oscillator strength and zero‐frequency refractive index were found to be 4.78 eV, 43.58 eV, 13.18 × 1013 m–2 and 3.18, respectively. From X‐ray powder diffraction study, the parameters of monoclinic unit cell were determined. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)