bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reporting of estimated glomerular filtration rate: Effect on physician recognition of chronic kidney disease and prescribing practices for elderly hospitalized patients
Authors: Quartarolo Jennifer M. , Thoelke Mark , Schafers Stephen J. 
Published: April 2007

AbstractBACKGROUNDPhysician recognition of chronic kidney disease (CKD) in elderly patients has been noted to be poor. These patients are at increased risk of medication dosing errors and acute renal failure.OBJECTIVETo investigate the effect of reporting estimated glomerular filtration rate (GFR) of elderly hospitalized patients on physician recognition of CKD and physician prescribing behaviors.DESIGNA retrospective combined with a prospective medical record review project.SETTINGA large academic medical center.PATIENTSPatients included were 65 years of age or older and had creatinine values within the normal laboratory range (< 1.6 mg/dL).INTERVENTIONReporting a calculated estimate of GFR to physicians.MEASUREMENTSRates of recognition of CKD were examined before and after the intervention. The effects of the intervention on prescription of renal‐dosed antibiotics and nonsteroidal anti‐inflammatory drugs (NSAIDS) and cyclooxygenase‐ 2 inhibitors (COX‐2) at hospital discharge were assessed.RESULTSA total of 260 and 198 patients were included before and after the intervention, respectively. Recognition of chronic kidney disease was low in both groups but demonstrated a significant increase following reporting of estimated GFR (3.9% to 12.6%, P < .001). Reporting of GFR was not associated with a significant decrease in prescription of NSAID/COX‐2 medications or increased rates of correct dosing of antibiotics (P = .10 and P = .81, respectively).CONCLUSIONSAlthough reporting of estimated GFR was associated with improved physician recognition of CKD in elderly hospitalized patients, it did not lead to a change in physician prescribing. More extensive interventions are necessary to increase recognition and decrease medication dosing errors. Journal of Hospital Medicine 2007;2:74–78. © 2007 of Hospital Medicine.
QSAR of multiple mutated antibodies
Authors: Mandrika Ilona , Prusis Peteris , Yahorava Sviatlana , Tars Kaspars , Wikberg Jarl E.S. 
Published: April 2007

AbstractThe aim of this study was to develop predictive quantitative structure–activity relationship (QSAR) modeling for antibody‐peptide interactions. A small single chain antibody library was designed and manufactured around the murine anti‐p24 (HIV‐1) monoclonal antibody CB4‐1 by use of statistical molecular design (SMD) principles and site directed mutagenesis, and its affinity for a p24 derived antigen was determined by fluorescence polarization. A satisfactory QSAR model (Q2 = 0.74, R2 = 0.88) was derived by correlating the affinity data to physicochemical property scales of the amino acids varied in the library. The model explains most of the antibody–antigen interactions of the studied set, and provides insights into the molecular mechanism involved in antigen binding. Copyright © 2007 John Wiley & Sons, Ltd.
Identification of discontinuous antigenic determinants on proteins based on shape complementarities
Authors: Rapberger Ronald , Lukas Arno , Mayer Bernd 
Published: April 2007

AbstractDiverse procedures for identifying antigenic determinants on proteins have been developed, including experimental as well as computational approaches. However, most of these techniques focus on continuous epitopes, whereas fast and reliable identification and verification of discontinuous epitopes remains barely amenable.In this paper, we describe a computational workflow for the detection of discontinuous epitopes on proteins. The workflow uses a given protein 3D structure as input, and combines a per residue solvent accessibility constraint with epitope to paratope shape complementarity measures and binding energies for assigning antigenic determinants in the conformational context. We have developed the procedure on a given set of 26 antigen–antibody complexes with a known structure, and have further expanded the available paratope shapes by generating a virtual paratope library in order to improve the screening for candidate residues constituting discontinuous epitopes. Applying the workflow on the 26 given antigens with known discontinuous epitopes resulted in the correct identification of the spatial proximity of 12 antigen–antibody interaction sites. Combining solvent accessibility, shape complementarity and binding energies towards the identification of discontinuous epitopes clearly outperforms approaches solely considering accessibility and residue distance constraints. Copyright © 2007 John Wiley & Sons, Ltd.
An investigation into time domain Doppler modelling using the TLM numerical method
Authors: Scott I. J. G. , de Cogan D. 
Published: April 2007

AbstractThe effects observed by a moving source and stationary receiver, or conversely stationary source and moving receiver are well known to physicists. The Doppler effect as it is commonly known is recognized as a perceived change in frequency of the incident signal upon the receiver, caused by the motion of either the source or receiver with respect to the stationary component, occurring in both electromagnetic (transverse) and acoustic (longitudinal) waves. This paper will primarily focus on the acoustic Doppler effect in the time domain, simulating a variety of scenarios using transmission line matrix (TLM) modelling in which the effect can be observed, proceeding to compare the accuracy of the various models generated. A new technique to allow arbitrary placement of boundaries of a TLM mesh will also be introduced and analysed allowing accurate placement of the moving walls within the simulation. Copyright © 2007 John Wiley & Sons, Ltd.
Effect of Camelina sativa expeller cake on performance and meat quality of broilers
Authors: Ryhänen Eeva‐Liisa , Perttilä Sini , Tupasela Tuomo , Valaja Jarmo , Eriksson Christian , Larkka Karita 
Published: April 2007

AbstractThe experiment was conducted to measure the effects of Camelina sativa expeller on the performance of broiler chickens and on the sensory quality and fatty acid composition of broiler meat. One‐day‐old broiler chickens were randomly allocated to the three dietary treatments which lasted 37 days. Experimental diets contained 0, 5 or 10% C. sativa expeller. Feed and water were offered ad libitum. The birds were weighed at the beginning, at 14 days and at the end of the trial at 37 days. Feed intake was recorded between weighings. C. sativa expeller reduced the growth of the birds linearly (P < 0.001). It also depressed their feed intake and feed conversion ratio during the starter phase (1–14 days). C. sativa did not cause any significant enlargement of the thyroid gland, nor were any liver lesions observed. Feeding of C. sativa significantly (P < 0.001) increased the omega‐3 fatty acid level in broiler meat. This was mainly due to an increase in α‐linolenic acid (18:3, n‐3). Feeding did not seem to have any adverse effect on the sensory quality of broiler meat. Meat from female broilers produced by feeding 5% C. sativa in the diet was significantly (P = 0.02) more tender than meat produced by feeding 10% C. sativa. Copyright © 2007 Society of Chemical Industry
Study of the oxidation of some catechols in the presence of 4‐amino‐3‐thio‐1,2,4‐triazole by digital simulation of cyclic voltammograms
Authors: Fotouhi Lida , Kiani Solmaz Taghavi , Nematollahi Davood , Heravi Majid M. 
Published: April 2007

AbstractElectrochemical oxidation of catechol and its derivatives (1a–d) has been studied in the presence of 4‐amino‐3‐thio‐1,2,4‐triazole (3) at various pHs. Some electrochemical techniques such as cyclic voltammetry using the diagnostic criteria derived by Nicholson and Shain for various electrode mechanisms and controlled‐potential coulometry were used. Results indicate the participation of catechols (1a–d) with 3 in an intramolecular cyclization reaction to form the corresponding 1,2,4‐triazino[5,4‐b]‐1,3,4‐thiadiazine derivatives. In various scan rates, based on an electron transfer–chemical reaction–electron transfer–chemical reaction mechanism, the observed homogeneous rate constants (kobs) for Michael addition reaction were estimated by comparing the experimental cyclic voltammetric responses with the digital simulated results. The oxidation reaction mechanism of catechols (1a–d) in the presence of 4‐amino‐3‐thio‐1,2,4‐triazole (3) was also studied. © 2007 Wiley Periodicals, Inc. Int J Chem Kinet 39: 340–345, 2007
Direct kinetics study of the product‐forming channels of the reaction of isoprene‐derived hydroxyperoxy radicals with NO
Authors: Patchen Amie K. , Pennino Michael J. , Kiep Annastassja C. , Elrod Matthew J. 
Published: April 2007

AbstractA direct kinetics study of the product‐forming channels of the reaction of isoprene‐derived hydroxyalkylperoxy radicals with NO has been performed at 100 Torr pressure and 298 K using the turbulent flow technique with high‐pressure chemical ionization mass spectrometry for the detection of reactants and products. For comparative purposes, a similar study was also performed for the reaction of 1‐ and 2‐butene‐derived hydroxyalkylperoxy radicals with NO. The measured hydroxyalkylnitrate product channel branching ratios were determined to be 0.061, 0.068, and 0.070 for the 1‐butene, 2‐butene, and isoprene systems, respectively. The results are compared to previous measurements of the hydroxyalkylnitrate‐branching ratios for these systems, and the atmospheric significance of the results is discussed. © 2007 Wiley Periodicals, Inc. Int J Chem Kinet 39: 353–361, 2007
Vascular Complications After Orthotopic Liver Transplantation After Neoadjuvant Therapy for Hilar Cholangiocarcinoma
Authors: Mantel Hendrik T.J. , Rosen Charles B. , Heimbach Julie K. , Nyberg Scott L. , Ishitani Michael B. , Andrews James C. , McKusick Michael A. , Haddock Michael G. , Alberts Steven R. , Gores Gregory J. 
Published: April 2007

Abstract

Liver transplantation after neoadjuvant chemoradiotherapy has emerged as an effective treatment for patients with localized, node-negative, unresectable hilar cholangiocarcinoma (CCA) or CCA arising in the setting of primary sclerosing cholangitis (PSC). However, concern has arisen regarding the potential for vascular complications due to high-dose neoadjuvant therapy before transplantation. We reviewed our experience with specific aims to determine the incidences of arterial, portal, and hepatic venous complications in patients transplanted for CCA compared with patients who undergo transplantation for other indications, and to describe patient outcome as a result of these vascular complications. We reviewed data for all patients who underwent liver transplantation for CCA between January 1993 and April 2006 and compared the incidences of vascular complications to whole organ and living donor recipient control groups. Sixty-eight patients underwent neoadjuvant therapy and subsequent liver transplantation. Arterial complications arose in 21%; portal venous complications arose in 22%; and overall, 40% developed vascular complications. Late hepatic artery complications occurred more often in living donor recipients transplanted for CCA compared with the living donor control group (P = 0.047). Late portal vein complications occurred more often in both whole organ and living donor recipients transplanted for CCA compared with the control groups (P = 0.01 and P = 0.009). Hepatic venous complications were rare. Patient and graft survival were not different between CCA and control patients. Liver transplantation with neoadjuvant therapy is associated with far higher rates of late arterial and portal venous complications, but these complications do not adversely affect patient and graft survival. Liver Transpl, 2007. © 2007 AASLD.
An efficient co‐rotational formulation for curved triangular shell element
Authors: Li Zhongxue , Vu‐Quoc Loc 
Published: April 2007

AbstractA 6‐node curved triangular shell element formulation based on a co‐rotational framework is proposed to solve large‐displacement and large‐rotation problems, in which part of the rigid‐body translations and all rigid‐body rotations in the global co‐ordinate system are excluded in calculating the element strain energy. Thus, an element‐independent formulation is achieved. Besides three translational displacement variables, two components of the mid‐surface normal vector at each node are defined as vectorial rotational variables; these two additional variables render all nodal variables additive in an incremental solution procedure. To alleviate the membrane and shear locking phenomena, the membrane strains and the out‐of‐plane shear strains are replaced with assumed strains in calculating the element strain energy. The strategy used in the mixed interpolation of tensorial components approach is employed in defining the assumed strains. The internal force vector and the element tangent stiffness matrix are obtained from calculating directly the first derivative and second derivative of the element strain energy with respect to the nodal variables, respectively. Different from most other existing co‐rotational element formulations, all nodal variables in the present curved triangular shell formulation are commutative in calculating the second derivative of the strain energy; as a result, the element tangent stiffness matrix is symmetric and is updated by using the total values of the nodal variables in an incremental solution procedure. Such update procedure is advantageous in solving dynamic problems. Finally, several elastic plate and shell problems are solved to demonstrate the reliability, efficiency, and convergence of the present formulation. Copyright © 2007 John Wiley & Sons, Ltd.
Topology optimization of dynamics problems with Padé approximants
Authors: Jensen Jakob S. 
Published: April 2007

AbstractAn efficient procedure for topology optimization of dynamics problems is proposed. The method is based on frequency responses represented by Padé approximants and analytical sensitivity analysis derived using the adjoint method. This gives an accurate approximation of the frequency response over wide frequency ranges and a formulation that allows for design sensitivities to be computed at low computational cost also for a large number of design variables. Two examples that deal with optimization of forced vibrations are included. Copyright © 2007 John Wiley & Sons, Ltd.
Conducting polyaniline‐coated nano silica by in situ chemical oxidative grafting polymerization
Authors: Lei Xiping , Su Zhixing 
Published: April 2007

AbstractPolyaniline (PAni) grafted nano silica were synthesized successfully by in situ polymerization of aniline (An) using ammonium persulphate (APS) as oxidant by three procedures: Firstly, γ‐(2,3‐epoxypropoxy)propyltrimethoxysilane (EPTMS) reacted with nano silica. Secondly, the EPTMS modified nano silica reacted with An as an initiator site introduced onto the silica surface, and finally PAni grafted silica was obtained by in situ chemical oxidative An. The chemical grafting of PAni was confirmed by FTIR and UV–Vis. The percentages of grafting EPTMS and An onto nano silica were 24.5 wt% and 10.3 wt%, respectively, calculated from elemental analysis (EA), while the percentage of grafting PAni was 157.7 wt% as a mass ratio of the grafting PAni and charged nano silica, investigated by TGA. In addition, characteristic agglomerate morphology of PAni was observed in the composite by SEM. The electrical conductivity of the product was 2.6 × 10−6 S cm−1 and it manifested that the resulted product was a typical semiconductor. Copyright © 2007 John Wiley & Sons, Ltd.
Preparation and characterization of poly(acrylic acid)‐iron rich smectite superabsorbent composites
Authors: Seki Yoldaş , Torgürsül Ali , Yurdakoc Kadir 
Published: April 2007

AbstractA novel poly(acrylic acid)‐iron rich smectite (IRS) superabsorbent composite was synthesized by graft copolymerization reaction of acrylic acid (AA) in the presence of N,N‐methylenebisacrylamide (MBA) as a crosslinker. IRS was used to strengthen the hydrogel products in the polymerization process. Water absorbencies for these superabsorbent composites in water and saline solutions were investigated. IRS caused a reduced equilibrium swelling as low as 8–26%. However, grafted IRS particles resulted in improved gel strength as high as 66% compared to the IRS‐free sample. IRS modified superabsorbent hydrogel composites exhibited higher thermal stability compared to the IRS‐free sample. The pH dependent reversible swelling behavior of hydrogels was also investigated. It is found that the swelling process is pH dependent and reversible for synthesized superabsorbent. Superabsorbent hydrogel composites were characterized by thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). FTIR spectroscopy was confirmed grafting of acrylic chains onto the surface of IRS particles. From the standpoint of these results, these strengthened and thermostabilized hydrogels may be considered as good candidates for a controlled release study and agricultural applications. Copyright © 2007 John Wiley & Sons, Ltd.
Role of BRAF‐V600E in the serrated pathway of colorectal tumourigenesis
Authors: Minoo P , Moyer MP , Jass JR 
Published: April 2007

AbstractThere is increasing evidence for an alternative pathway of sporadic colorectal tumourigenesis that is associated with DNA microsatellite instability (MSI), due to methylation and loss of expression of the mismatch repair gene MLH1. Recent studies have highlighted a serrated pathway of colorectal cancer (CRC) in which serrated polyps with activating mutations in BRAF progress to CRCs with MSI following methylation and silencing of MLH1. The present study provides a novel mechanistic experimental model for these clinical observations. We investigated the role of BRAF activating mutation (BRAF‐V600E) in colorectal tumourigenesis by studying the effects of forced expression of BRAF‐V600E in the ‘normal’ colon epithelial NCM460 cell line and by targeting endogenous BRAF‐V600E in MSI‐High (MSI‐H) colon cancer cell lines. The findings indicate that BRAF mutation in colon epithelial cells contributes to a gain in resistance towards apoptotic stimuli, which is likely to be an important characteristic of pre‐malignant serrated lesions. BRAF‐V600E also plays a role in the development and maintenance of transformed and invasive phenotypes in colon epithelial cells. Our findings also suggest that BRAF mutation potentiates promoter hypermethylation of the MLH1 gene promoter. Together, these results highlight BRAF as a potential target for therapeutic intervention in sporadic MSI‐H colorectal cancers. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
β‐Thalassemia major births after National Screening Program in Taiwan
Authors: Chern Jimmy P.S. , Lin Kai‐Hsin , Lu Meng‐Yao , Lin Dong‐Tsamn , Jou Shiann‐Tarng , Yang Yung‐Li , Chang Hsiu‐Hao , Su Syi , Lin Kuo‐Sin 
Published: April 2007

AbstractObjectiveA National Thalassemia Screening Program was adopted in Taiwan in 1993. This report examined that program's results and impact.MethodsPatients with β‐thalassemia major born between 1994 and 2003 were recruited through the help of all thalassemia clinics in Taiwan. A structured questionnaire was designed to collect the reasons for affected births.ResultsThere were 97 affected births from 1994 to 2003.These births resulted after informed choice (n = 4), screening problems (n = 83), and undetermined causes (n = 10). Approximately 83% (5/6) of affected births in 2003 came from interracial marriages.ConclusionsThis report has identified several areas that might improve the thalassemia‐screening program, including carrier screening in high school rather than in early pregnancy and the involvement of genetic counselors, providing care of new female immigrants. Pediatr Blood Cancer 2008;50:58–61. © 2007 Wiley‐Liss, Inc.
Composite adrenal anaplastic neuroblastoma and virilizing adrenocortical tumor with germline TP53 R248W mutation
Authors: Rossbach Hans‐Christoph , Baschinsky Dmitry , Wynn Tung , Obzut Dana , Sutcliffe Maxine , Tebbi Cameron 
Published: April 2007

AbstractComposite tumors are extremely rare. Such tumors in adrenal glands are usually of neuroendocrine‐neural type and occur mostly in adults. Their pathogenesis remains elusive. We report a patient with composite neuroblastoma (NB), adrenocortical tumor (ACT), and Li‐Fraumeni syndrome (LFS) with germline TP53 R248W mutation. LFS predisposes to the development of leukemia, sarcomas, adrenocortical and breast carcinomas, brain tumors and, questionably, NB. A unique correlation between a single TP53 mutation (R337H) and ACT has been reported in southern Brazilian children. It remains unclear at this time whether a similar association of NB and R248W in patients with LFS exists. Pediatr Blood Cancer 2008;50:681–683. © 2007 Wiley‐Liss, Inc.
Photopolymerization kinetics of cycloaliphatic epoxide–acrylate hybrid monomer
Authors: He Yong , Xiao Ming , Wu Feipeng , Nie Jun 
Published: April 2007

AbstractAn epoxide–acrylate hybrid monomer was synthesized by the controlled reaction of a cycloaliphatic epoxide and acrylic acid. The photopolymerization kinetics was investigated using a real‐time infrared spectroscopy technique. The influences of photoinitiator concentration, free radical initiator and polymerization atmosphere on the polymerization were studied. The hybrid monomer showed unique photopolymerization kinetics in the photopolymerization process and the final conversions of epoxy groups and acrylate double bonds were improved synchronously. Dynamic mechanical analysis results demonstrated that the hybrid monomer cured film formed a more uniform polymer network than the blend of epoxy acrylate and epoxide. Copyright © 2007 Society of Chemical Industry
Studies on the kinetics and mechanism of the copolymerization of acrylonitrile with styrene in the presence of zinc chloride
Authors: Srivastava N. , Rai J. S. P. 
Published: April 2007

AbstractRadical copolymerization of acrylonitrile (AN) with styrene (Sty), using x,x′‐azobisisobutyronitrile as initiator, was carried out in the presence of zinc chloride (ZnCl2) dilatometrically at 65/pm 0.1 C for 120min. The rate of polymerization was a direct function of the concentrations of ZnCl2, AN and Sty, and polymerization temperature. The viscosity‐average molecular weight of the copolymer increased with ZnCl2 concentration. The energy of activation in the presence and absence of the complex was evaluated as 82.5 kJ mol−1 and 115.5 kJ mol−1, respectively. The copolymerization of AN with Sty proceeded via the radical‐complex mechanism.
Dielectric relaxation studies of heterogeneously substituted cellulose acetate and its plasticization by dibutyl phthalate
Authors: Doyle Stephen J. , Pethrick Richard A. 
Published: April 2007

AbstractDielectric relaxation measurements are reported on plasticized commercial and heterogeneously substituted cellulose acetate. Differences in the observed behaviour are attributed to the retention of a degree of crystallinity and microscopic structure in the original substituted cellulose samples. A comparison of dynamic mechanical and dielectric relaxation data further emphasizes the influence of the nature of the original morphology on the micro dynamics.