bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a cancer prevention‐detection clinic
Authors: Mettlin Curtis , Boyle Michele , Michalek Arthur 
Published: February 2007

AbstractControl of cancer through risk reduction and early detection has great potential. Roswell Park Memorial Institute's Prevention‐Detection Center addresses a community need for health promotion, disease prevention, and cancer detection as well as providing opportunity for research on the efficacy of such a program. The Prevention‐Detection Center offers a range of services including education, genetic counseling, risk assessment, counseling in smoking cessation and other means of risk reduction, and screening for cancer. It is also involved in evaluation of new technologies of cancer detection such as the ultrasonic examination of the breast. A community outreach program is aimed at attracting high‐risk populations. In its first eighteen months of operation; the Prevention‐Detection Center detected 24 confirmed cancers. The Center is used by approximately 60 persons each week. Interviews with persons using the clinic over a two‐week period indicate that most are motivated to attend because a relative has had cancer or because of a belief in the importance of regular checkups. Client satisfaction with the clinic is high. Although many of the activities of the Prevention‐Detection Center have a research dimension, many of its activities and services are suited to the community ambulatory health care setting.
Sarcoma of the buttock: A trend toward limb‐saving resection
Authors: Gerson Robert , Shiu Man H. , Hajdu Steven I. 
Published: February 2007

AbstractA retrospective comparison was made between soft tissue sarcomas of the buttock treated during two consecutive periods at one institution: (1) 1966‐1978, during which almost all tumors were treated by radical buttectomy with limb preservation, often in conjunction with radiation therapy, and (2) 1934‐1966, as previously reported by Wanebo et al, in which treatment by hemipelvectomy was frequently offered. Desmoid tumors were excluded. The five‐year survival rates after curative treatment were almost identical, 40% vs 39%, respectively. Distant metastases were the main cause of death. Very high local recurrence rates were recorded after therapy: 45% vs 39% for the respective periods. Local recurrences seemed prone to occur with large, deeply fixed sarcomas, particularly when inadequate or no radiation therapy had been utilized. These observations point to the need for innovative methods to prevent local tumor recurrence and a trial of adjuvant chemotherapy if long‐term cure with limb preservation is to be achieved.
Hyperthermic regional perfusion with melphalan and a combination of melphalan and actinomycin D in the treatment of locally metastasized malignant melanomas of the extremities
Authors: Martijn H. , Oldhoff J. , Koops H. Schraffordt 
Published: February 2007

AbstractFrom September 1969 through 1979, 68 patients with already locally metastasized malignant melanomas of the extremities were treated by hyperthermic regional perfusion and local excision(s). Of these, 53 patients could be evaluated after a follow‐up of at least 2 years: 31 had been perfused with melphalan and 22 with melphalan in combination with actinomycin D. Local recurrence rates were about the same in both groups: 32 versus 33%. The same applied to the symptom‐free interval between perfusion and local recurrence: about 12 versus about 13 months. Virtually all recurrences in both groups (90 versus 85%) were seen within 2 years. The interval between perfusion and systemic metastization was also roughly the same: about 25 versus about 23 months. These results indicate the need for better chemotherapeutics in order to achieve further improvement. The results of these perfusions were otherwise by no means disappointing, and hyperthermic regional perfusion is indicated in the treatment of patients with locally metastasized malignant melanomas.
Acute appendicitis as a sign of a colorectal carcinoma
Authors: Arnbjörnsson Einar 
Published: February 2007

AbstractThe relationship of acute appendicitis occurring previous to cancer in colon and rectum was studied in the consecutive records of 561 patients, of 40 years of age and older, operated upon with an appendectomy because of acute appendicitis. Sixteen (2.9%) of these patients were readmitted within three years because of a carcinoma in colon or rectum. The incidence of carcinoma in the colon and rectum in the population, of the same age, is only 0.1%, according to the Swedish Cancer Registry (1). This difference is statistically significant. Where acute appendicitis and colon carcinoma co‐exist, the danger is that the carcinoma may be missed. Therfore, any patient over the age of 40 presenting with acute appendicitis should be carefully checked for carcinoma in the colon.
Antigen specificity of squamous cancers of the head and neck based on tumor site using the slide leukocyte adherence inhibition assay
Authors: Taylor S. G. , Safford P. C. 
Published: February 2007

AbstractPatients with a diagnosis of squamous cancer of the upper aerodigestive (UAD) system were tested with extracts of squamous cancer arising from several regions of the UAD tract and compared to various control populations, using the slide leukocyte adherence inhibition (LAI) assay. Seven tumor extracts were tested. Twenty‐five of 77 tests (32%) were positive in unselected UAD squamous cancer patients. However, matching patients with tumor extract by the site of origin within the UAD tract, 19 of 22 tests (86%) were positive when the site of origin was identical for leukocyte donor and extract. Two of four patients tested with an extract prepared from a different site within the same region of the UAD system were positive; whereas only 4 of 51 tests (8%) were positive in patients tested with an extract from a cancer arising from a different region within the UAD tract (P < 0.001). One of 33 tests using patients with either no cancer (11 tests), squamous cancer of other regions (15), or adenocarcinoma (7) reacted to the extracts of UAD tract cancers. We conclude that patients with squamous cancer of the UAD tract can recognize distinct tumor‐associated antigens that are site‐specific and are non‐cross‐reactive using the LAI technique.
Pericardial effusion as first evidence of malignancy in bronchogenic carcinoma
Authors: Sulkes Aaron , Weshler Zeev , Kopolovic Yuri 
Published: February 2007

AbstractTwo patients in whom the development of a malignant pericardial effusion lead to the diagnosis of an unsuspected bronchogenic carcinoma are presented. Pericardial involvement has rarely been described as the first manifestation of an underlying lung tumor. Histologic type in both cases was adenocarcinoma, the most commonly described pattern in this situation. In concurrence with previous reports, prognosis of patients with malignant pericardial effusion remains poor.
Primary tumors of the small bowel: A clinicopathological study of 58 cases
Authors: Gupta Saroj , Gupta Saroj 
Published: February 2007

AbstractVarious reviews documenting the rarity, diagnostic problems, and poor survival statistics prompted this retrospective clinicopathological study of 58 cases of primary small bowel tumors, periampullary and mesenteric tumors excluded, over a 14‐year period between 1966 and 1979 inclusive. Of these cases 36 were male and 22 were female, ranging in age from 13 to 65 years. Initially, the symptoms were vague and ill defined. Prominent clinical features were: intermittent abdominal pain (64%), loss of weight (62%), abdominal lump (53%), and chronic bleeding (7%). Routine barium meal examination and laboratory investigations were not helpful in preoperative diagnosis. Of these tumors 28 were benign and 30 malignant, with the commonest benign and malignant tumors being leiomyoma and lymphoma, respectively. The commonest site of involvement was the ileum both for benign and malignant lesions. None of the benign tumors was found in the duodenum. All patients with benign tumors, discovered either at laparotomy for intestinal obstruction or during surgical procedures for other diseases, had excision of the tumor through enterotomy or resection of small bowel with end‐to‐end anastomosis. Of 30 patients with malignant tumors, 12 underwent resection of the growth and end‐to‐end anastomosis. Of the remaining 18 unresectable cases, 7 had by‐pass procedures and 11 had only biopsy. All patients of benign tumors are well without any gastrointestinal symptoms. All the malignant cases, except three cases of adenocarcinoma and two of lymphoma who underwent resection, died within 5 years. The 5‐year survival of only 8.6% in malignant tumors indicates the necessity of an early exploratory laparotomy in doubtful cases with vague abdominal symptoms. A bold interventionist approach should improve the otherwise dismal outlook of malignant small bowel tumors.
The relation between the status of adaptive system and the number of postoperative complications in patients with gastrointestinal cancer: The effect of phenazepam
Authors: Ostroumova M. N. , Simonov N. N. , Kovalev V. K. , Bernstein M. I. 
Published: February 2007

AbstractThe decrease in 11‐hydroxycorticosteroids concentration caused by 0.5 mg of dexamethasone administered at 11 pm was studied in 91 primary patients suffering from gastrointestinal cancer. In dexamethasone‐resistant patients postoperative complications developed in 65% of colon cancer patients and in 42% of stomach cancer patients. In dexamethasone‐sensitive patients the complications were observed in 24% and 12% of patients, correspondingly. The elevation of hypothalamic threshold of sensitivity to the inhibiting effect of glucocorticoids, revealed by the dexamethasone suppression test, was considered to be a result of a combined action of age, the tumor itself, and pronounced emotional stress during the preparation for operation. The derivative of benzodiazepin ‐ phenazepam ‐ when administered before the operation in colon cancer patients improved the results of the dexamethasone suppression test and decreased the number of postoperative complications.
Squamous cell carcinoma arising in branchiogenic cyst branchial cleft carcinoma
Authors: Jablokow Victor R. , Kathuria Satinder , Wang Taishine 
Published: February 2007

AbstractSquamous cell carcinoma that developed in branchial cleft cyst in a 53‐year‐old male is described. The tumor was focally invasive. The tumor fulfilled criteria advocated by Martin for substantiating carcinoma as primary in the branchial cleft cyst.The patient has survived for 4.5 years after radical neck dissection and radiation without manifesting primary or recurrent tumor locally or elsewhere.One of the major critera in diagnosing squamous cell carcinoma as primary tumor in the branchiogenic cyst is to prove that it has arisen in normal epithelial lining [2, 3].In our case there is transition of the tumor from normal squamous epithelial lining of the cyst to malignancy.
Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: A southwest oncology group study
Authors: Cruz Anatolio B. , Perkins Matilda , Aust J. Bradley , Coltman Charles A. , Pollard Ester B. , Fletcher William S. , Kennedy Peter , Lehane Daniel E. , Mira Joaquin , McCracken Joseph D. , Sorgen Stephen D. , Page Carey P. , Pendleton Olga J. , Reddy Eashwer , Sapp Joan , Smith Frank 
Published: February 2007

AbstractForty‐three patients with Stage III or IV squamous cell carcinoma of the head and neck were treated with simultaneous hydroxyurea and bleomycin in four treatment levels and with full‐dose radiotherapy. Complete responses ranged from 28 to 50% (P = .47), and complete plus partial responses ranged from 57 to 84% (P = .50), in a total of 33 patients. The primary toxicity was moderate to severe mucositis and minimal leukopenia. Despite good initial response, long‐term survival duration was not greater than was that for historical controls.
Malignant pleural mesothelioma with a 14‐year survival: A case report and electronmicroscopic study
Authors: Klima Marcella , Spjut Harlan J. , Bossart Mattie I. , Frazier O. Howard , Cooley Denton H. 
Published: February 2007

AbstractA patient with malignant pleural mesothelioma and surviving 15 years is presented. During this time she has had 15 thoractomies for removal of persistent tumor. The histological sections were reviewed from 1967–1981, and it was found that the tumor had remained essentially unchanged. Ten different specimens were examined electronmicroscopically; no ultrastructural changes were detected.
Malignant duodenocolic fistulas: A case report and review of the literature
Authors: Chang Alfred E. , Rhoads Jonathan E. 
Published: February 2007

AbstractA case of primary malignant duodenocolic fistula is presented. Colonic carcinoma is the most common etiology of this entity. Clinical features include diarrhea, weight loss, anemia, and feculent vomiting. Review of the literature indicates that the treatment of choice is a right hemicolectomy with a pancreaticoduodenectomy or segmental duodenectomy if the disease is localized. Forty‐six percent of patients undergoing this procedure have been reported to be alive more than 2.5 years later. If the disease is disseminated, the best palliative procedure appears to be a right hemicolectomy with a partial duodenectomy. The early morbidity and mortality associated with this latter procedure have been attributed most often to dehiscence of the duodenal closure.
Hexamethylmelamine and melphalan as salvage therapy in advanced ovarian carcinoma
Authors: Tempero Margaret A. , Kessinger Anne 
Published: February 2007

AbstractTen patients with advanced ovarian carcinoma were treated with hexa‐methylmelamine and melphalan after failing first‐line combination chemotherapy. In eight patients residual disease was evident only at second‐look laparotomy. Surgical debulking was accomplished in four patients but only two patients had residual disease of less than 2 cm. Two of these four patients are alive without evidence of disease at 20 and 24 months. The remaining patients have expired (median survival 6 months). The combination of hexamethylmelamine and melphalan after surgical debulking at second‐look operation may improve the salvage of patients with advanced ovarian carcinoma.
Adjuvant Chemotherapy of Adult High‐Grade Soft Tissue Sarcoma
Authors: Mills E. E. D. 
Published: February 2007

AbstractOf 12 adult patients with high‐grade soft tissue sarcoma receiving adjuvant chemotherapy and at risk for 36–84 months, 9 (75%) remain metastasis free and 10 (83%) have adequate local disease control with limb preservation. This is significantly better (P > 0.015) than a comparable “historic” control of 48 previously treated patients. The results correlate well with the few similar studies reported.
Carcinoma of the gallbladder–a natural history type of study
Authors: Jönsson Per‐Ebbe , Pettersson Bo Adrian 
Published: February 2007

AbstractA retrospective analysis of the natural history of 63 consecutive patients with gallbladder cancer during 30 years at a county hospital in Sweden is presented. Dominating symptoms were pain, jaundice, weight loss, and a palpable mass. Fifty patients were subjected to surgery. Forty‐one patients had an extensive tumor spread in the abdominal cavity. Twenty‐six patients were cholecystectomized and in 24 patients biopsy from the tumor was the only measure taken. The gallbladder cancer was occult in four patients. The median survival time was 1 month in patients who underwent autopsy, 2 months in patients who were biopsied and 4 months in patients who were cholecystectomized. The overall 6‐month and 1‐year crude survival rates were 16% and 8%, respectively. Comparison with previous reports regardless of treatment reveals that the prognosis of gallbladder cancer is still dismal and unchanged.
Local skin flaps in reconstruction following excision of basal cell carcinomas of the cheek and temple
Authors: Abdel‐Fattah A. M. A. 
Published: February 2007

AbstractTwenty‐seven male patients had been treated surgically for basal cell carcinomas of the temple and cheek. Eighteen tumors were classically nodular, seven cystic, and two cicatricial. A safety margin of 0.5–1.0 cm in nodular and cystic tumors, and 1.0–1.5 cm in cicatricial variety has proven satisfactory. Reconstruction has been achieved by local skin flap: Limberg rhomboid flap for the temple, cheek transposition flap for the anterior portion of the cheek, combined pre‐ and postauricular transposition flaps for the middle part of the cheek and advancement flap(s) with Bürow's triangles for tumours of the preauricular region. Principles and practical points of each flap have been discussed. The proposed safety margins have been enough to clear the lesions as proved by histopathological examination. Cosmetic result has been satisfactory, and there has been no recurrence over a period of 6 months to 3 years.
Sensitivity of proliferating human breast epithelial cells to hypotonic treatment
Authors: Goldstone Stephen E. , Stanyon Roscoe , Lan Sam 
Published: February 2007

AbstractAn assay for colony‐forming cells of breast epithelia derived from normal and malignant surgical specimens is described using an IMR 90 fibroblast feeder layer. Their radiosensitivity (Do: 120–172) is consistent with the proliferative origin of the colonies. Distilled water inhibits proliferation of a proportion of the colony‐forming cells after a 1‐minute exposure. Continued detection of colonies after 10 minutes of exposure indicates that it is an inefficient way of completely eradicating proliferating epithelial cells of normal and malignant origin.
Chemotherapeutic treatment of the NB rat adenocarcinoma androgen‐insensitive tumor III
Authors: Drago Joseph R. 
Published: February 2007

AbstractSingle and combination chemotherapy were evaluated in the treatment of these Nb rat prostate adenocarcinomas. Single‐agent treatment consisted of 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea (BCNU), cyclophosphamide, adriamycin, and cis‐platinum; the combination therapy included BCNU and adriamycin; BCNU, adriamycin, and 5‐fluorouracil; cyclophosphamide and cis‐platinum; adriamycin and cis‐platinum; and adriamycin, cis‐platinum, and cyclophosphamide. Controls had a metastatic incidence of 46%. The best results as measured by tumor volume and low incidence of metastasis were achieved with triple drug therapy utilizing adriamycin, cis‐platinum, and cyclophosphamide; and cis‐platinum and cyclophosphamide. This tumor, Nb Pr A.I. III, has proven to be the most unresponsive tumor in the Noble prostatic adenocarcinoma prostate model. No animal treated with any of the above regimes had complete tumor regression.
Hepatomas in young women on oral contraceptives: Report of two cases and review of the literature
Authors: Gala Kirit V. , Griffin Thomas W. 
Published: February 2007

AbstractHepatocellular carcinoma (HCC) developed in two women who had ingested oral contraceptives for prolonged duration. One of the patients had hepatoma restricted to the liver, and it was successfully resected. The other patient presented with metastatic HCC to the sacrum and lung, and she died after an initial response to chemotherapy in 12 months. Review of literature showed 23 previously reported cases of HCC associated with “pill” use since 1973. Although the reported instances of HCC in pill users are few in number, the majority of affected females were in their 20s and early 30s, without any preexisting liver disease. Even though the risk of developing HCC on oral contraceptives is low, this association adds to the list of complications induced by oral contraceptives in premenopausal women. Two cases are reported and literature reviewed.
Synchronous bilateral primary germ cell tumors of the testis: A case report and review of the literature
Authors: Hoekstra H. J. , Mehta D. M. , Koops H. Schraffordt 
Published: February 2007

AbstractSynchronous bilateral primary germ cell tumors of the testis are exceedingly rare. The most common synchronous testicular tumors are seminomas, followed by embryonal carcinomas, teratocarcinomas, and choriocarcinomas. In a series of 385 patients we found nine with bilateral primary germ cell tumors of the testis (2.3%), including one with synchronous involvement of both testes. The treatment of synchronous bilateral primary germ cell tumors of the testis is in principle the same as that of solitary testicular primary germ cell tumors, and is based on tumor histology and tumor metastasis.
Gastroscopic cytology and biopsies in diagnosis of gastric malignancies
Authors: Gupta J. P. , Jain A. K. , Agrawal B. K. , Gupta Saroj 
Published: February 2007

AbstractThe outcome in gastric malignancy has changed in recent years owing to its early and accurate diagnosis employing fiber‐optic endoscopy and histocytology. One hundred and two subjects with endoscopic demonstration of various gastric lesions were subjected for brush cytology and multiple biopsies. Observing a high degree of specificity, the accuracy of brush cytology was 81% and histology 72% with cumulative diagnostic yield of 91%. There was no false‐positive report with cytology; histology, however, gave three false‐positive results. The present study thus confirms the high diagnostic accuracy of brush cytology combined with multiple biopsies in gastric malignancies.
Central venous access in oncology patients: The “peel‐away” sheath for rapid insertion
Authors: Aitken Delmar R. , Catalano Richard , Minton John P. 
Published: February 2007

AbstractA safe, fluoroscopically controlled method of rapid silastic catheter introduction in oncology patients provides long‐term access to a high blood flow area near the right atrium. A “peel‐away” disposable sheath and introducer have been adapted for the rapid introduction of the catheter. Benefits of the use of this technique are that (1) it can be easily adapted from the widely known technique of central venous line placement, (2) catheter position is easily confirmed by fluoroscopy, and (3) the procedure can be performed under local anesthesia, minimizing anesthetic risks and expense.
Alternating multiagent chemotherapy for advanced ovarian cancer
Authors: Hernandez Enrique , Rosenshein Neil B. , Villar Jose , Dillon Michael B. , Ettinger David S. , Order Stanley E. 
Published: February 2007

AbstractA chemotherapy regimen consisting of hexamethylmelamine (H) 150 mg/ m2 orally days 1–14, cyclophosphamide (C) 500 mg/m2 IV day 1 of a 28‐day cycle with Adriamycin (A) 40 mg/m2 IV day 1 alternating with cisdiamminechloroplatinum (C‐P) 50 mg/m2 IV day 1 every other cycle was administered to 29 patients with advanced epithelial ovarian cancer. Toxicity to this regimen included alopecia, nausea, and vomiting in all patients. Mild paresthesias occurred in four patients. Hematologic toxicity required only minimal dose modification. There was no cardiac, renal, or auditory toxicity. The clinical response rate of 55% and median survival of 14 months compare favorably with that of other reported series. This chemotherapy regimen seems to be well tolerated without jeopardizing the patients' response.
Ewing's sarcoma of the phalangeal bone
Authors: Chen KARL T. K. , McGann Peter D. , Flam Marshall S. 
Published: February 2007

AbstractA rare case of Ewing's sarcoma of the toe bone is described and compared with three reported cases of phalangeal Ewing's sarcoma. The lesion in two cases was initially treated as infection and the diagnosis was delayed for several months. Roentgenographic and aspiration cytology examinations in cases with clinically unresolving infection of the hands and feet may prevent delayed diagnosis. Radical surgery alone may be curative if no metastases are found preoperatively in careful clinical investigations.