bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percepción de madres sobre la atención de enfermería en el servicio de crecimiento y desarrollo
Authors: Madero Zambrano Kendy Paola , Manrique Anaya Yolima Marleby , Guerrero Camargo Sergio Andrés , Lopez Correa Laura Mercedes 
Published: March 2024

Introducción: EL programa de crecimiento y desarrollo es una estrategia que permite identificar la evolución adecuada de los menores de 5 años a través de la valoración de los profesionales de enfermería. Objetivo: Determinar la Satisfacción De Madres Sobre La Calidad De La Atención Recibida Por Enfermería En El Servicio De Control De Crecimiento Y Desarrollo. Cartagena 2022. Materiales y Métodos: estudio cuantitativo descriptivo de tipo transversal. La muestra correspondió a 604 madres con hijos menores de 1 año que asisten al Control de Crecimiento y Desarrollo y que desearan participar en el estudio, para la recolección de la información se aplicó el instrumento tipo escala de Likert denominado: Satisfacción de la madre Resultados: las madres adultas jóvenes evalúan la dimensión humana como alta dada la habilidad del profesional para hacer empatía con el menor, la dimensión oportuna, continua y segura estuvo en alta a razón que logra identificar las necesidades del menor y brindar las orientaciones precisas además de mantener la seguridad durante la consulta, el porcentaje de las dimensiones estuvo por encima del 80% Conclusión: Influye el comportamiento y las habilidades del profesional en enfermería para garantizar la adherencia al programa y a las sugerencias que se puedan derivar de la valoración del menor en cada control. Palabras Claves: enfermería, satisfacción, calidad de la atención de salud, madres, crecimiento y desarrollo.
Quantized Proportional-Integral Tracking Control for Two-Stage Chemical Reactor Systems
Authors: Sakthivel R. , Priyanka S. , Shobana N. , Mohanapriya S. 
Published: March 2024

Abstract
This paper is concerned with the problem of proportional-integral tracking control of a two-stage chemical reactor system subject to time delays, disturbances, uncertainties, and input quantization. In this work, an improved equivalent-input-disturbance estimator is incorporated into the proportional-integral tracking control system to compensate for the disturbances in the addressed model. Moreover, to minimize the communication congestion in the control networks, the quantized control input signals are considered while designing the controller. Further, a robust stability condition for the addressed system is established in the form of linear matrix inequalities by employing asymmetric Lyapunov–Krasovskii functional and Jensen's integral inequalities. Moreover, in accordance with the derived conditions, the control and observer gain matrices are determined. Finally, a numerical example is provided to demonstrate the validity of the proposed control scheme.
Comprehensive evaluation of nucleic acid amplification methods widely used for generic detection of sandfly-borne phleboviruses
Authors: Polat Ceylan , Ayhan Nazli , Ergünay Koray , Charrel Remi N. 
Published: March 2024

ABSTRACT

Sandfly-borne phleboviruses (SBPs), which cause sandfly fever, aseptic meningitis, encephalitis, and meningoencephalitis, are emerging pathogens of major public health concern. Virus nucleic acid testing is essential for SBP diagnosis, especially in the early stages of infection, and for the discovery of novel SBPs. The efficacy of utilizing generic primers that target conserved nucleotide sequences for the detection of both known and novel SBPs has not been extensively evaluated. We aimed to compare and evaluate the performance of five generic primer sets, widely used to detect S- and L-segments of arthropod-borne phleboviruses and designed as singleplex (
n
= 3) and nested (
n
= 2) formats, including both well-known and recently characterized 15 Old World virus strains. Furthermore, we performed
in silico
analysis to assess the detection capabilities of these generic primer sets. The initial evaluation of previously published generic primer sets for SBP detection yielded two singleplex primer sets with the potential to be adapted for use in real-time or high-throughput detection settings. Studies are ongoing to develop and further optimize a preliminary assay and test various hosts and vectors to assess their capacity to detect known and novel viruses.

IMPORTANCE
Virus nucleic acid testing is the primary diagnostic method, particularly in the early stages of illness. Virus-specific or syndromic tests are widely used for this purpose. The use of generic primers has had a considerable impact on the discovery, identification, and detection of Old World sandfly-borne phleboviruses (OWSBP). The study is significant because it is the first to carry out a comparative evaluation of all published OWSBP generic primer sets.
Learning curve of achieving competency in emergency endoscopy in upper gastrointestinal bleeding: how much experience is necessary?
Authors: Allo Gabriel , Lang Sonja , Martin Anna , Bürger Martin , Zhang Xinlian , Chon Seung-Hun , Nierhoff Dirk , Töx Ulrich , Goeser Tobias , Kasper Philipp 
Published: March 2024

ObjectivesThe management of upper gastrointestinal bleeding (UGIB) has seen rapid advancements with revolutionising innovations. However, insufficient data exist on the necessary number of emergency endoscopies needed to achieve competency in haemostatic interventions.DesignWe retrospectively analysed all oesophagogastroduodenoscopies with signs of recent haemorrhage performed between 2015 and 2022 at our university hospital. A learning curve was created by plotting the number of previously performed oesophagogastroduodenoscopies with signs of recent haemorrhage against the treatment failure rate, defined as failed haemostasis, rebleeding and necessary surgical or radiological intervention.ResultsThe study population included 787 cases with a median age of 66 years. Active bleeding was detected in 576 cases (73.2%). Treatment failure occurred in 225 (28.6%) cases. The learning curve showed a marked decline in treatment failure rates after nine oesophagogastroduodenoscopies had been performed by the respective endoscopists followed by a first plateau between 20 and 50 procedures. A second decline was observed after 51 emergency procedures followed by a second plateau. Endoscopists with experience of <10 emergency procedures had higher treatment failure rates compared with endoscopists with >51 emergency oesophagogastroduodenoscopies performed (p=0.039) or consultants (p=0.041).ConclusionsOur data suggest that a minimum number of 20 oesophagogastroduodenoscopies with signs of recent haemorrhage is necessary before endoscopists should be considered proficient to perform emergency procedures independently. Endoscopists might be considered as advanced-qualified experts in managing UGIB after a minimum of 50 haemostatic procedure performed. Implementing recommendations on minimum numbers of emergency endoscopies in education programmes of endoscopy trainees could improve their confidence and competency in managing acute UGIB.
The impact of policy and policy communication on COVID-19 vaccination inequalities among Venezuelan refugees and migrants in Colombia: a comparative cross-sectional interrupted time-series analysis
Authors: Gomez Wilson , Fernández-Niño Julián A , Guillén José Rafael , Stevenson Megan , Ortíz Jennifer , Barriga Talero Miguel Ángel , López Jhon Jairo , Núñez Ricardo Luque , Spiegel Paul , Page Kathleen R , Ramirez Correa Jhon Fredy , Porras Damary Martínez , Wirtz Andrea L 
Published: March 2024

IntroductionEquitable access to vaccines for migrants and refugees is necessary to ensure their right to health and to achieve public health goals of reducing vaccine-preventable illness. Public health policies require regulatory frameworks and communication to effect uptake of effective vaccines among the target population. In Colombia, the National COVID-19 Vaccination Plan implicitly included Venezuelan refugees and migrants; however, initial communication of the policy indicated that vaccine availability was restricted to people with regular migration status. We estimated the impact of a public announcement, which clarified access for refugees and migrants, on vaccination coverage among Venezuelans living in Colombia.MethodsBetween 30 July 2021 and 5 February 2022, 6221 adult Venezuelans participated in a cross-sectional, population-based health survey. We used a comparative cross-sectional time-series analysis to estimate the effect of the October 2021 announcement on the average biweekly change in COVID-19 vaccine coverage of Venezuelans with regular and irregular migration status.Results71% of Venezuelans had an irregular status. The baseline (preannouncement) vaccine coverage was lower among people with an irregular status but increased at similar rates as those with a regular status. After the announcement, there was a level change of 14.49% (95% CI: 1.57 to 27.42, p=0.03) in vaccination rates among individuals with irregular migration status with a 4.61% increase in vaccination rate per biweekly period (95% CI: 1.71 to 7.51, p=0.004). By February 2022, there was a 26.2% relative increase in vaccinations among individuals with irregular migration status compared with what was expected without the announcement.ConclusionWhile there was no policy change, communication clarifying the policy drastically reduced vaccination inequalities across migration status. Lessons can be translated from the COVID-19 pandemic into more effective global, regional and local public health emergency preparedness and response to displacement.
Effectiveness of shared medical appointments delivered in primary care for improving health outcomes in patients with long-term conditions: a systematic review of randomised controlled trials
Authors: Tang Mei Yee , Graham Fiona , O'Donnell Amy , Beyer Fiona , Richmond Catherine , Dhami Raenhha , Sniehotta Falko F , Kaner Eileen F S 
Published: March 2024

ObjectivesTo examine the effectiveness of shared medical appointments (SMAs) compared with one-to-one appointments in primary care for improving health outcomes and reducing demand on healthcare services by people with one or more long-term conditions (LTCs).DesignA systematic review of the published literature.Data sourcesSix databases, including MEDLINE and Web of Science, were searched 2013–2023. Relevant pre-2013 trials identified by forward and backward citation searches of the included trials were included.Eligibility criteriaRandomised controlled trials of SMAs delivered in a primary care setting involving adults over 18 years with one or more LTCs. Studies were excluded if the SMA did not include one-to-one patient-clinician time. All countries were eligible for inclusion.Data extraction and synthesisData were extracted and outcomes narratively synthesised, meta-analysis was undertaken where possible.ResultsTwenty-nine unique trials were included. SMA models varied in terms of components, mode of delivery and target population. Most trials recruited patients with a single LTC, most commonly diabetes (n=16). There was substantial heterogeneity in outcome measures. Meta-analysis showed that participants in SMA groups had lower diastolic blood pressure than those in usual care (d=−0.086, 95% CI=−0.16 to –0.02, n=10) (p=0.014). No statistically significant differences were found across other outcomes. Compared with usual care, SMAs had no significant effect on healthcare service use. For example, no difference between SMAs and usual care was found for admissions to emergency departments at follow-up (d=−0.094, 95% CI=−0.27 to 0.08, n=6, p=0.289).ConclusionsThere was a little difference in the effectiveness of SMAs compared with usual care in terms of health outcomes or healthcare service use in the short-term (range 12 weeks to 24 months). To strengthen the evidence base, future studies should include a wider array of LTCs, standardised outcome measures and more details on SMA components to help inform economic evaluation.PROSPERO registration numberCRD42020173084.
Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder
Authors: Wang Jie , Zhao Wenfeng , Wang Huang , Leng Haixia , Xue Qing , Peng Mao , Min Baoquan , Jin Xiukun , Tan Liucen , Gao Keming , Wang Hongxing 
Published: March 2024

BackgroundAlthough 15 mA transcranial alternating current stimulation (tACS) has a therapeutic effect on depression, the activations of brain structures in humans accounting for this tACS configuration remain largely unknown.AimsTo investigate which intracranial brain structures are engaged in the tACS at 77.5 Hz and 15 mA, delivered via the forehead and the mastoid electrodes in the human brain.MethodsActual human head models were built using the magnetic resonance imagings of eight outpatient volunteers with drug-naïve, first-episode major depressive disorder and then used to perform the electric field distributions with SimNIBS software.ResultsThe electric field distributions of the sagittal, coronal and axial planes showed that the bilateral frontal lobes, bilateral temporal lobes, hippocampus, cingulate, hypothalamus, thalamus, amygdala, cerebellum and brainstem were visibly stimulated by the 15 mA tACS procedure.ConclusionsBrain-wide activation, including the cortex, subcortical structures, cerebellum and brainstem, is involved in the 15 mA tACS intervention for first-episode major depressive disorder. Our results indicate that the simultaneous involvement of multiple brain regions is a possible mechanism for its effectiveness in reducing depressive symptoms.
PHOX2B: a diagnostic cornerstone in neurocristopathies and neuroblastomas
Authors: Windels Mei-Lan , Cordier Fleur , Van Dorpe Jo , Ferdinande Liesbeth , Creytens David 
Published: March 2024

Paired-like homeobox 2B (PHOX2B) is a gene essential in the development of the autonomic nervous system.PHOX2Bmutations are associated with neurocristopathies—Hirschsprung disease (HSCR) and congenital central hypoventilation syndrome (CCHS)—and peripheral neuroblastic tumours. PHOXB2 plays an important role in the diagnostics of these conditions.Genotyping of aPHOX2Bpathogenic variant is required to establish a diagnosis of CCHS. In HSCR patients, PHOX2B immunohistochemical staining has proven to be a valuable tool in identifying this disease. Furthermore,PHOXB2is a predisposition gene for neuroblastoma, in which PHOX2B immunohistochemical staining can be used as a highly sensitive and specific diagnostic marker. The utility of PHOX2B immunohistochemistry in pheochromocytoma and paraganglioma has also been studied but yields conflicting results.In this review, an overview is given ofPHOX2B, its associated diseases and the usefulness of PHOX2B immunohistochemistry as a diagnostic tool.
An oncolytic vaccinia virus encoding hyaluronidase reshapes the extracellular matrix to enhance cancer chemotherapy and immunotherapy
Authors: Wang Shibing , Li Yuxin , Xu Chuning , Dong Jie , Wei Jiwu 
Published: March 2024

BackgroundThe redundant extracellular matrix (ECM) within tumor microenvironment (TME) such as hyaluronic acid (HA) often impairs intratumoral dissemination of antitumor drugs. Oncolytic viruses (OVs) are being studied extensively for cancer therapy either alone or in conjunction with chemotherapy and immunotherapy. Here, we designed a novel recombinant vaccinia virus encoding a soluble version of hyaluronidase Hyal1 (OVV-Hyal1) to degrade the HA and investigated its antitumor effects in combination with chemo drugs, polypeptide, immune cells, and antibodies.MethodsWe constructed a recombinant oncolytic vaccinia virus encoding the hyaluronidase, and investigated its function in remodeling the ECM of the TME, the antitumor efficacy both in vitro and in several murine solid tumors either alone, or in combination with chemo drugs including doxorubicin and gemcitabine, with polypeptide liraglutide, with immune therapeutics such as PD-L1/PD-1 blockade, CD47 antibody, and with CAR-T cells.ResultsCompared with control OVV, intratumoral injection of OVV-Hyal1 showed superior antitumor efficacies in a series of mouse subcutaneous tumor models. Moreover, HA degradation by OVV-Hyal1 resulted in increased intratumoral dissemination of chemo drugs, infiltration of T cells, NK cells, macrophages, and activation of CD8+T cells. When OVV-Hyal1 was combined with some antitumor therapeutics, for example, doxorubicin, gemcitabine, liraglutide, anti-PD-1, anti-CD47 blockade, or CAR-T cells, more profound therapeutic outcomes were obtained.ConclusionsOVV-Hyal1 effectively degrades HA to reshape the TME, therefore overcoming some major hurdles in current cancer therapy, such as limited OVs spread, unfavored dissemination of chemo drugs, polypeptides, antibodies, and insufficient infiltration of effector immune cells. OVV-Hyal1 holds the promise to improve the antitumor outcomes of current cancer therapeutics.
The complex hyperbolic form as a Weil–Petersson form
Authors: Wang Xiangsheng 
Published: March 2024

For the moduli space of the punctured spheres, we find a new equality between two symplectic forms defined on it. Namely, by treating the elements of this moduli space as the singular Euclidean metrics on a sphere, we give an interpretation of the complex hyperbolic form, i.e. the Kähler form of the complex hyperbolic structure on the moduli space, as a kind of Weil–Petersson form.
MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
Authors: Ito Koichi , Harada Ibuki , Martinez Criseyda , Sato Katsutoshi , Lee EunJee , Port Elisa , Byerly Jessica H. , Nayak Anupma , Tripathi Ekta , Zhu Jun , Irie Hanna Y. 
Published: March 2024

Abstract

Epithelial–mesenchymal transition (EMT) in cancer promotes metastasis and chemotherapy resistance. A subset of triple-negative breast cancer (TNBC) exhibits a mesenchymal gene signature that is associated with poor patient outcomes. We previously identified PTK6 tyrosine kinase as an oncogenic driver of EMT in a subset of TNBC. PTK6 induces EMT by stabilizing SNAIL, a key EMT-initiating transcriptional factor. Inhibition of PTK6 activity reverses mesenchymal features of TNBC cells and suppresses their metastases by promoting SNAIL degradation via a novel mechanism. In the current study, we identify membrane-associated RING-CH2 (MARCH2) as a novel PTK6-regulated E3 ligase that promotes the ubiquitination and degradation of SNAIL protein. The MARCH2 RING domain is critical for SNAIL ubiquitination and subsequent degradation. PTK6 inhibition promotes the interaction of MARCH2 with SNAIL. Overexpression of MARCH2 exhibits tumor suppressive properties and phenocopies the effects of SNAIL downregulation and PTK6 inhibition in TNBC cells, such as inhibition of migration, anoikis resistance, and metastasis. Consistent with this, higher levels of MARCH2 expression in breast and other cancers are associated with better prognosis. We have identified MARCH2 as a novel SNAIL E3 ligase that regulates EMT and metastases of mesenchymal TNBC.

Significance:
EMT is a process directly linked to drug resistance and metastasis of cancer cells. We identified MARCH2 as a novel regulator of SNAIL, a key EMT driver, that promotes SNAIL ubiquitination and degradation in TNBC cells. MARCH2 is oncogene regulated and inhibits growth and metastasis of TNBC. These insights could contribute to novel strategies to therapeutically target TNBC.
Impact of Advanced Therapy Centers on Characteristics and Outcomes of Heart Failure Admissions
Authors: Lu Daniel Y. , Kanduri Jaya , Yeo Ilhwan , Goyal Parag , Krishnan Udhay , Horn Evelyn M. , Karas Maria G. , Sobol Irina , Majure David T. , Naka Yoshifumi , Minutello Robert M. , Cheung Jim W. , Uriel Nir , Kim Luke K. 
Published: March 2024

BACKGROUND:
Although much attention has been paid to admission and transfer patterns for cardiogenic shock, contemporary data are lacking on decompensated heart failure (HF) admissions and transfers and the impact of advanced therapy centers (ATCs) on outcomes.

METHODS:
HF hospitalizations were obtained from the Nationwide Readmissions Database 2016 to 2019. Centers performing at least 1 heart transplant or left ventricular assist device were classified as ATCs. Patient characteristics, outcomes, and procedural volume were compared among 3 cohorts: admissions to non-ATCs, admissions to ATCs, and transfers to ATCs. A secondary analysis evaluated outcomes for severe HF hospitalizations (cardiogenic shock, cardiac arrest, and mechanical ventilation). Multivariable logistic regression was performed to adjust for the presence of HF decompensations and significant clinical variables during univariate analysis.

RESULTS:

A total of 2 331 690 hospitalizations (81.2%) were admissions to non-ATCs (94.5% of centers), 525 037 (18.3%) were admissions to ATCs (5.5% of centers), and 15 541 (0.5%) were transferred to ATCs. Patients treated at ATCs (especially those transferred) had higher rates of HF decompensations, procedural frequency, lengths of stay, and costs. Unadjusted mortality was 2.6% at non-ATCs and was higher at ATCs, both for directly admitted (2.9%,
P
<0.001) and transferred (11.2%,
P
<0.001) patients. However, multivariable-adjusted mortality was significantly lower at ATCs, both for directly admitted (odds ratio, 0.82 [95% CI, 0.78–0.87];
P
<0.001) and transferred (odds ratio, 0.66 [95% CI, 0.57–0.78];
P
<0.001) patients. For severe HF admissions, unadjusted mortality was 37.2% at non-ATCs and was lower at ATCs, both for directly admitted (25.3%,
P
<0.001) and transferred (25.2%,
P
<0.001) patients, with similarly lower multivariable-adjusted mortality.

CONCLUSIONS:
Patients with HF treated at ATCs were sicker but associated with higher procedural volume and lower adjusted mortality.
Object-Centric Scene Representations Using Active Inference
Authors: Van de Maele Toon , Verbelen Tim , Mazzaglia Pietro , Ferraro Stefano , Dhoedt Bart 
Published: March 2024

Abstract
Representing a scene and its constituent objects from raw sensory data is a core ability for enabling robots to interact with their environment. In this letter, we propose a novel approach for scene understanding, leveraging an object-centric generative model that enables an agent to infer object category and pose in an allocentric reference frame using active inference, a neuro-inspired framework for action and perception. For evaluating the behavior of an active vision agent, we also propose a new benchmark where, given a target viewpoint of a particular object, the agent needs to find the best matching viewpoint given a workspace with randomly positioned objects in 3D. We demonstrate that our active inference agent is able to balance epistemic foraging and goal-driven behavior, and quantitatively outperforms both supervised and reinforcement learning baselines by more than a factor of two in terms of success rate.
The Myth of the Theons
Authors: Heehs Peter 
Published: March 2024

Abstract
The reputations of Eliezer Mordechai Bimstein and Mary Ware (aka Theon and Madame Theon) as master occultists took shape during their lifetimes in the absence of accurate biographical information. Best known as leaders of the Cosmic Movement, which attracted a number of adherents during the first decade of the twentieth century, they each had an interesting backstory, Bimstein as a worker in the tobacco trade, then co-founder of the Hermetic Brotherhood of Luxor, Ware as Mother Superior of a convent, then poet, actress, and lecturer on occult themes. Their teachings, published in the Revue Cosmique and Tradition Cosmique, influenced such people as Louis Thémanlys and Mirra Alfassa, later the Mother of the Sri Aurobindo Ashram. Biographical material on Bimstein and Ware, brought to light by recent scholars, has led to a deconstruction of the myth of the Theons but this does not necessarily detract from the interest of their writings.