bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined therapy with human cord blood cell transplantation and basic fibroblast growth factor delivery for treatment of myocardial infarction
Authors: Cho Seung‐Woo , Kim Il‐Kwon , Bhang Suk Ho , Joung Boyoung , Kim Young Jin , Yoo Kyung Jong , Yang Yoon‐Sun , Choi Cha Yong , Kim Byung‐Soo 
Published: August 2007

AbstractBackground:Transplanting cord blood‐derived cells has been shown to augment neovascularization in ischaemic tissue.Aim:To test whether sustained delivery of basic fibroblast growth factor (bFGF) enhances the efficacy of angiogenic cord blood mononuclear cell (CBMNC) transplantation therapy in treating myocardial infarction.Methods:Three weeks after myocardial infarction, Sprague‐Dawley rats were randomised to either injection of medium only (control), CBMNC transplantation, sustained bFGF delivery, or combined CBMNC transplantation and sustained bFGF delivery. Six weeks after treatment, tissue formation, neovascularization, and apoptotic activity in the infarct regions were evaluated by histology and immunohistochemistry. Left ventricular (LV) dimensions and function were evaluated by magnetic resonance imaging.Results:Combined bFGF delivery and CBMNC transplantation significantly enhanced neovascularization in the ischaemic myocardium, as compared with either therapy alone. The enhanced neovascularization was likely due to increased VEGF and bFGF expression. The combined therapy also exhibited a reduced infarct area and apoptosis in the ischaemic myocardium, as compared with either individual therapy. The combined therapy did not attenuate LV dilation or increase ejection fraction significantly over either individual therapy.Conclusion:This study demonstrates that sustained bFGF delivery enhances the angiogenic efficacy of CBMNC transplantation in rat myocardial infarction models.
Effect of sildenafil on ventilatory efficiency and exercise tolerance in pulmonary hypertension
Authors: Oudiz Ronald J. , Roveran Giorgio , Hansen James E. , Sun Xing‐Guo , Wasserman Karlman 
Published: August 2007

AbstractBackground:The pulmonary vasculopathy in pulmonary arterial hypertension (PAH) results in increased resistance to pulmonary blood flow, limiting the cardiac output required for the increased O2 demands of exercise.Aims:We sought to determine the physiologic basis for clinical improvement in PAH patients receiving sildenafil, hypothesizing that the key mechanisms of improvement are improved blood flow and ventilatory efficiency, leading to improved exercise capacity and O2 pulse over time.Methods:We studied 28P AH patients with (n=14) and without (n=14) sildenafil treatment. All received warfarin and diuretic therapy, and 13/14 sildenafil‐treated patients were already receiving specific PAH drugs. Cardiopulmonary exercise testing was performed before and after sildenafil.Results:Peak VO2, peak O2 pulse, VE/CO2 and PETCO2, were 0.84±0.1 L/min, 6.1±0.7 mL beat−1, 49±2 and 26±1.5 mm Hg, and improved after adding sildenafil to 0.91±0.1 L/min, 6.8±0.8 mL beat−1, 43±2, and 30±1.9, respectively, whereas control patients worsened (p=0.012, 0.008, 0.008 and 0.0002, treated vs. controls, respectively).Conclusions:Sildenafil improves PETCO2, VE/VCO2, peak O2 pulse and peak VO2 during exercise compared to controls. A prospective, placebo‐controlled study is needed to validate these findings.
The effect of hypoxia at different embryonic ages on impairment of memory ability in chicks
Authors: Rodricks Candice L. , Gibbs Marie E. , Jenkin Graham , Miller Suzanne L. 
Published: August 2007

AbstractHypoxia during the prenatal period is a principal antecedent to cognitive impairment after birth. In this study we have investigated the duration, severity and timing of acute hypoxia during chick embryonic development to elucidate the relative importance of these factors. Our results show that 24 h of hypoxia (exposure to 14% oxygen) at embryonic day 10 (E10) results in significant impairment of intermediate and long‐term memory in the post‐hatch chick, which is the same as we observed with 4 days of hypoxia. At E14, 24 h of hypoxia, 5 min of anoxia, but not 1 h of hypoxia, resulted only in impaired long‐term memory; the same as 4 days of hypoxia from E14. Corticosterone levels, measured post‐hatch as an indicator of a stress response, were significantly elevated in response to E10 hypoxia, and E14 hypoxia (both 1 and 24 h) and anoxia. In a separate experiment we exposed embryos to 24 h of hypoxia from E6 to E16, and found that memory deficits resulted from hypoxia at E9 and E10, and E13–E15, while corticosterone concentrations at hatch were significantly raised following E10–E16 hypoxia. These results demonstrate that the developmental age when the insult occurs determines the nature of the cognitive deficit and, if the severity of the insult is sufficient, then the outcome, or deficits in memory ability, are consistent whether the insult is acute or chronic. Importantly, there are two critical stages in development, which in the chick are around E10 and E14, when acute hypoxia results in significant adverse cognitive effects after hatch. These time‐points correspond to two different stages in growth and development.
May–June precipitation reconstruction of southwestern anatolia, Turkey during the last 900 years from tree rings
Authors: Touchan Ramzi , Akkemik Ünal , Hughes Malcolm K. , Erkan Nesat 
Published: August 2007

AbstractA May–June precipitation reconstruction (AD 1097–2000) has been developed for southwestern Anatolia in Turkey, the longest reported to date in this region. The reconstruction was derived from a regional Juniperus excelsa chronology that was built from material sampled at four sites in the Antalya and Mersin Districts. The regional tree-ring chronology accounts for 51% of the variance of instrumentally observed May–June precipitation. The years AD 1518 to 1587 are the most humid period in the reconstruction, coinciding with a major shift in European climate. The driest 70-year period in the reconstruction is AD 1195 to 1264. The period AD 1591–1660 represents the third driest and was characterized by instability climatically, politically, and socially in Anatolia.
A science metrics based citation for tagging the biomedical researchers
Authors: Brandao Adeilton 
Published: August 2007

AbstractWith the thousands of scientific papers being produced every month, picking an authors name, associate it to a research field and right evaluate his or her performance is in most of times a cumbersome task. I am proposing here that science indexes as h-index, g-index, total citations and published papers could be added to biomedical bibliographic citation in order to create a unique identifier for a given researcher.
Pioneering Modern Corporate Governance: A View from London in 1900
Authors: Hannah Leslie 
Published: August 2007

Around 1900 Britain was exceptionally suited to pioneering large scale enterprises because of the precocious development of its equity markets and London's experimentation with a more eclectic range of corporate governance techniques than the world's smaller and less cosmopolitan financial centers. Information dissemination, incentives, and reputation—developed by a serendipitous mix of legal compulsions and flexible voluntarism—set the scene for the growth of large, UK-based, national and international corporations in the twentieth century.“The investment business is not with us as well developed or as well understood as it is in England.”W. H. Lyon, Capitalization (Boston, 1913), 207.
Anglerfish catchability for swept-area abundance estimates in a new survey trawl
Authors: Reid D. G. , Allen V. J. , Bova D. J. , Jones E. G. , Kynoch R. J. , Peach K. J. , Fernandes P. G. , Turrell W. R. 
Published: August 2007

Abstract
Reid, D. G., Allen, V. J., Bova, D. J., Jones, E. G., Kynoch, R. J., Peach, K. J., Fernandes, P. G., and Turrell, W. R. 2007. Anglerfish catchability for swept-area abundance estimates in a new survey trawl. – ICES Journal of Marine Science, 64: 1503–1511. In 2005, a new trawl survey was launched in Scotland to estimate anglerfish (Lophius spp.) abundance using swept-area estimates. This required an understanding of the herding of the fish by the gear, particularly in the zone between the doors and wing ends. TV observations at the wing ends and along the sweeps were used to quantify the behavioural reactions of anglerfish. These observations were analysed to develop a gear efficiency estimate. This paper details the construction of the net and the procedures for data collection on the survey. In all, 54 reliable observations of anglerfish were recorded at the groundgear, the wing ends, and along the sweep/bridle combination. Detailed analysis of the recordings showed that all fish in the path of the net were captured, whereas more than half of the fish between the wings and the doors were not. The fish did not appear to herd and many of the encounters with the wires were passive. An individual-based particle-tracking model was constructed to use the behavioural observations to simulate the capture process and generate an efficiency factor. The calculated efficiency factor, based on the behavioural observations, was 1.04, indicating that almost all fish encountering the sweeps and bridles were lost. The implications and suggestions for development of this work are discussed.
Lemierre Syndrome: Two Cases and a Review
Authors: Syed Mohammed Iqbal , Baring David , Addidle Michael , Murray Craig , Adams Calum 
Published: August 2007

AbstractObjectives: Lemierre syndrome is usually caused by an acute oropharyngeal infection in previously healthy young adults, resulting in thrombophlebitis of the internal jugular vein, leading to metastatic septic embolization and bacteraemia. The usual organism is Fusobacterium necrophorum. Lemierre syndrome, not so long ago labeled as the “forgotten disease,” is on the rise. Today with increasing antibiotic‐resistant organisms, and decreasing awareness of the syndrome, subsequent re‐emergence of this “forgotten disease” is becoming more common in clinical settings. Lemierre syndrome has significant morbidity. Cranial nerve complications associated with the condition have been increasingly diagnosed in the last few years. Looking back at literature on Lemierre syndrome, there have been review articles in medical and microbiology journals but rarely in otolaryngology journals. By presenting our cases we demonstrate the diverse presentations and severity of the illness.Methods: A review of the literature and a case report on two cases seen in our institution in the last year are presented. Each of these had varied presentations and neurologic complications—one developed 9th to 12th cranial nerve palsies and Horner syndrome, which have not been described in previous literature, and the other developed polyneuropathy and a frontal lobe infarct among other multisystem complications.Conclusions: Diagnosis of Lemierre syndrome is not always straightforward as clinical features are variable and blood cultures are often negative. Awareness of the syndrome and a high degree of suspicion are needed.
Dual Regulation Role of GH3.5 in Salicylic Acid and Auxin Signaling during Arabidopsis-Pseudomonas syringae Interaction
Authors: Zhang Zhongqin , Li Qun , Li Zhimiao , Staswick Paul E. , Wang Muyang , Zhu Ying , He Zuhua 
Published: August 2007

Abstract
Salicylic acid (SA) plays a central role in plant disease resistance, and emerging evidence indicates that auxin, an essential plant hormone in regulating plant growth and development, is involved in plant disease susceptibility. GH3.5, a member of the GH3 family of early auxin-responsive genes in Arabidopsis (Arabidopsis thaliana), encodes a protein possessing in vitro adenylation activity on both indole-3-acetic acid (IAA) and SA. Here, we show that GH3.5 acts as a bifunctional modulator in both SA and auxin signaling during pathogen infection. Overexpression of the GH3.5 gene in an activation-tagged mutant gh3.5-1D led to elevated accumulation of SA and increased expression of PR-1 in local and systemic tissues in response to avirulent pathogens. In contrast, two T-DNA insertional mutations of GH3.5 partially compromised the systemic acquired resistance associated with diminished PR-1 expression in systemic tissues. The gh3.5-1D mutant also accumulated high levels of free IAA after pathogen infection and impaired different resistance-gene-mediated resistance, which was also observed in the GH3.6 activation-tagged mutant dfl1-D that impacted the auxin pathway, indicating an important role of GH3.5/GH3.6 in disease susceptibility. Furthermore, microarray analysis showed that the SA and auxin pathways were simultaneously augmented in gh3.5-1D after infection with an avirulent pathogen. The SA pathway was amplified by GH3.5 through inducing SA-responsive genes and basal defense components, whereas the auxin pathway was derepressed through up-regulating IAA biosynthesis and down-regulating auxin repressor genes. Taken together, our data reveal novel regulatory functions of GH3.5 in the plant-pathogen interaction.
MicroRNA-Mediated Regulation of Stomatal Development inArabidopsis
Authors: Kutter Claudia , Schöb Hanspeter , Stadler Michael , Meins Frederick , Si-Ammour Azeddine 
Published: August 2007

AbstractThe proper number and distribution of stomata are essential for the efficient exchange of gases between the atmosphere and the aerial parts of plants. We show that the density and development of stomatal complexes on the epidermis of Arabidopsis thaliana leaves depend, in part, on the microRNA-mediated regulation of Agamous-like16 (AGL16), which is a member of the MADS box protein family. AGL16 mRNA is targeted for sequence-specific degradation by miR824, a recently evolved microRNA conserved in the Brassicaceae and encoded at a single genetic locus. Primary stomatal complexes can give rise to higher-order complexes derived from satellite meristemoids. Expression of a miR824-resistant AGL16 mRNA, but not the wild-type AGL16 mRNA, in transgenic plants increased the incidence of stomata in higher-order complexes. By contrast, reduced expression of AGL16 mRNA in the agl16-1 deficiency mutant and in transgenic lines overexpressing miR824 decreased the incidence of stomata in higher-order complexes. These findings and the nonoverlapping patterns of AGL16 mRNA and miR824 localization led us to propose that the miR824/AGL16 pathway functions in the satellite meristemoid lineage of stomatal development.
A WD40 Domain Cyclophilin Interacts with Histone H3 and Functions in Gene Repression and Organogenesis inArabidopsis
Authors: Li Hong , He Zengyong , Lu Guihua , Lee Sung Chul , Alonso Jose , Ecker Joseph R. , Luan Sheng 
Published: August 2007

AbstractChromatin-based silencing provides a crucial mechanism for the regulation of gene expression. We have identified a WD40 domain cyclophilin, CYCLOPHILIN71 (CYP71), which functions in gene repression and organogenesis in Arabidopsis thaliana. Disruption of CYP71 resulted in ectopic activation of homeotic genes that regulate meristem development. The cyp71 mutant plants displayed dramatic defects, including reduced apical meristem activity, delayed and abnormal lateral organ formation, and arrested root growth. CYP71 was associated with the chromatin of target gene loci and physically interacted with histone H3. The cyp71 mutant showed reduced methylation of H3K27 at target loci, consistent with the derepression of these genes in the mutant. As CYP71 has close homologs in eukaryotes ranging from fission yeast to human, we propose that it serves as a highly conserved histone remodeling factor involved in chromatin-based gene silencing in eukaryotic organisms.
On the transferability of “traditional” satisfaction theory to non‐traditional employment relationships: temp agency work satisfaction
Authors: Torka Nicole , Schyns Birgit 
Published: August 2007

PurposeThe main purpose of this paper is to identify sources of temp agency work satisfaction and discuss whether or not these sources differ from those well‐known to traditional satisfaction research (i.e. those appropriate for employees with a permanent contract).Design/methodology/approachThe paper is a qualitative study (semi‐structured interviews and fieldwork) among low and medium skilled metalworkers (welders and fitters) in two Dutch companies. The authors were able to identify sources for temp agency work satisfaction: organizational conditions, central personality constructs, labour market experiences, and layoff experiences.FindingsThe findings in the paper conclude that satisfaction theory is transferable to temp agency workers, but that future satisfaction research should include less studied factors such as labour market and layoff experiences, as well.Research limitations/implicationsThe paper is a qualitative case study research within two Dutch companies and involved a certain occupational group: metalworkers. Consequently, the external transferability of the results (i.e. country, occupational group, industries) may be limited. Furthermore, the research approach used does not allow for the making of casual assumptions. For example, it was not possible to address the question as to whether “perceived alternatives” influences “sensation seeking” or vice versa. Longitudinal questionnaire research could help to clarify such issues. Job satisfaction theory in general is helpful in creating a framework for agency work satisfaction when it comes to Human Resource Management policies and practices. However, in order to explain agency workers' satisfaction, there is a need to broaden the traditional psychologically‐orientated theories and include aspects related to history and (occupational) sociology such as work experience in sectors where non‐permanent employment relationships are common.Practical implicationsThe paper shows that hiring‐in companies can contribute to agency workers' satisfaction and, it is believed, other non‐permanent workers such as freelancers and collegial loan‐in, by means of equal treatment policies and practices with respect to job characteristics, development and mobility policies, working conditions, direct employee influence, and (fringe‐) benefits.Originality/valueIn this paper the focus has been on a relatively seldom‐discussed phenomenon in employee attitude research: temp agency work satisfaction. The authors focus on sources that can explain the preference for a ménage à trois employment relationship over life‐time employment arrangements with one employer, i.e. a traditional permanent labour contract between two parties.
Maximising women's potential in the UK's retail sector
Authors: Harris Lynette , Foster Carley , Whysall Paul 
Published: August 2007

PurposeThe purpose of the paper is to show that a defining characteristic of the UK retail sector is the high number of women it employs but there remains an enduring under‐representation of women in its management positions. The majority of women in the industry work part‐time and this paper aims to explore the factors that impact upon the career progression.Design/methodology/approachIn the paper, 1,000 questionnaires were completed by store staff in three leading retailers, supported by interviews with store staff and SME retailers in the UK's East Midlands region.FindingsThe paper finds continuing barriers to career progression for women working part‐time in retailing. Despite family friendly employment policies becoming an increasingly important feature of modern work organisations, career progression was informed by a traditional concept of a career based on full‐time working.Research limitations/implicationsThe paper was limited to one sector. There is a need for further studies into women's career progression in other sectors reliant on female employment.Practical implicationsThe findings in the paper have implications for promotion policies, training and development provision and line management practices if retailers are to maximise the potential of the women they employ.Originality/valueThe paper suggests that retailing is an industry where a significant number of women are working below their potential despite organisational policies supportive of diversity and equality of opportunity.
The labour dispute arbitration system in China
Authors: Shen Jie 
Published: August 2007

PurposeThe purpose of the paper is to analyse the characteristics, development and implementation of the Chinese labour arbitration system and its role in settling labour disputes.Design/methodology/approachThe paper analyses official statistics and the arbitral cases published on the web sites of government labour and social security departments.FindingsThe paper finds that labour arbitration has become the most important mechanism for settling labour disputes in China since the middle 1990s. This trend indicates the fading of traditional political and administrative means due to the decreasing influence of governmental labour administration and the subordinate status of trade unions, and the emergence of the rule of law in setting labour terms. The effectiveness and fairness of labour arbitration is to a certain extent constrained by its limitations and workers' weak position in employment relations that prohibit it from fully upholding the Labour Law.Research limitationsThe paper shows that there is a paucity of literature devoted to labour arbitration in China. Further research is necessary to study labour arbitration, particularly the issues concerning: the frequency and reasons for workers to compromise in demands when claims, especially unfair dismissal cases; the process and the way in which arbitrators handle cases and make decisions; the fairness of arbitration awards; and the ways for improving competency and neutrality of arbitrators and arbitration committees.Practical implicationsThe paper shows that the party‐appointed method is necessary to improve the two parties' control of arbitration process. The public should be allowed to access to case and arbitrator related information in order to increase the transparency of arbitration.Originality/valueThis is the first paper that introduces the labour arbitration system in China and analyzes its role in setting labour disputes and its potential for improvement.