bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multilingual advantages
Authors: Siemund Peter , Lorenz Eliane 
Published: March 2024

Abstract
In this contribution, we provide a critical reassessment of multilingual advantages, especially in the context of learning additional languages. Although there is widespread agreement that multilingual experience enhances language learning, a precise definition of the relevant conditions remains a challenge. After a topical overview, we discuss several case studies focusing on language learning advantages, interdependence, and cross-linguistic influence in different multilingual constellations. This discussion covers contexts of balanced bilingualism, heritage bilingualism, institutionally planned multilingualism, minority language bilingualism, as well as multilingual settings in which English is used as a Lingua Franca. In addition, we elaborate on two conditions (type of bilingualism, type of language knowledge) that impact language learning in multilingual settings. It is important to distinguish between balanced and unbalanced bilinguals as well as general language proficiencies and grammatical knowledge. On the whole, this paper is a warning against foregone conclusions and an invitation to a more thoughtful approach to a highly fascinating field.
Bilingualism matters
Authors: Peristeri Eleni , Baldimtsi Eleni , Tsimpli Ianthi M. , Durrleman Stephanie 
Published: March 2024

Abstract
This study investigated bilingualism effects on language, executive functions and Theory of Mind (ToM) in children with Autism Spectrum Disorder (ASD), and with Developmental Language Disorder (DLD). The performance of these clinical groups was compared to that of children with typical development (TD). All groups were matched on socio-economic status, IQ and chronological age (oscillating around 11 years), and were composed of a total of one hundred and twenty-two participants. Overall, children with ASD and DLD showed more difficulty than their TD peers on language tasks, and monolingual children with ASD struggled more than other groups on both EF and ToM tasks. Bilingualism boosts in executive functions and ToM emerged in bilingual children with ASD compared to their monolingual peers with ASD, however these bilingual advantages were not observed in children with DLD. More specifically, bilinguals with ASD performed better than their monolingual peers at inhibiting distracting non-verbal stimuli and at attributing false beliefs. Bilingual autistic children’s performance in the ToM task related to IQ, sentence comprehension and (marginally) to socio-economic status. Taken together, these findings highlight the selective cognitive benefits of bilingualism, which may vary depending on the children’s condition, on their individual cognitive and linguistic abilities, as well as on their socio-economic backgrounds. This work also shows that bilingualism has no negative effects on children’s development, including those with ASD or DLD.
Multimodal story-retelling
Authors: Yang Cheng-Xiang , Lin Yen-Liang 
Published: March 2024

Abstract
Cognitive load has been shown to influence speakers’ gesture production, but how it effects the duration, form, and functions of gestures is not yet well understood. This study examines how increased cognitive load influenced the production of co‑speech and co‑thought gestures by second language (L2) learners, and further looks at how different types of gestures correspond to specific functions. Twenty-four English as an L2 participants were recruited and required to watch a pre-determined cartoon and then retell the story in English. Participants were divided into two cognitive load conditions for the story retelling: one group was given a task structure for story retelling, while the other was not. The results of this study show that enhancing cognitive load significantly increased the frequency of both co‑speech and co‑thought gestures and the duration of co‑speech gestures, but not co‑thought gestures. With regard to the correspondence of gesture types and their functions for conceptualization (i.e., activation, manipulation, packaging, exploration), this study found co‑speech and co‑thought gestures serve different functions in L2 narrative tasks. Activation is dominant in every type of co‑speech gesture, especially in iconic and metaphoric gestures. Deictic gestures mostly function for packaging and exploration and co‑thought gestures for exploration and manipulation. This study provides necessary clarification on the relationship between cognitive load and gestures, including novel interactions of gesture duration and functions of gestures for conceptualization.
Heritage language education
Authors: Torres Julio 
Published: March 2024

Abstract
This chapter provides a brief overview of heritage language education and its potential role in supporting heritage language learners’ bi/multilingualism. We begin by considering the multifaceted nature of heritage language education programs and courses to address heritage language learners’ goals and needs. The chapter then outlines five major dimensions that currently contribute to the design and implementation of curricula for heritage language learners: grammar properties, pedagogical models, critical language awareness, policies, program development and institutionalization. The remainder of the discussion focuses on future directions by examining four critical areas that can help advance the effectiveness of education programs for heritage language learners. The overview of the chapter stems from scholarly perspectives, initiatives, and efforts with diverse heritage language learner populations across a number of international settings.
From Practice to Public Health: Broadening Neuropsychology’s Reach & Value—An Introduction to the National Academy of Neuropsychology’s 2022 Annual Conference Special Issue
Authors: Del Bene Victor A , Walker Keenan A 
Published: March 2024

Abstract
This special issue is centered around presentations from the National Academy of Neuropsychology 2022 Annual Conference. The theme of the conference, “From Practice to Public Health: Broadening Neuropsychology’s Reach & Value” is pivotal for the field’s future. With an ever-shifting technological landscape and recent changes in clinical practice post-COVID, we are left wondering how neuropsychology will develop. How will we use biomedical and technological advances, such as blood-based Alzheimer’s disease biomarkers or passive digital recordings, to improve clinical care and further expand our understanding of disease mechanisms? As neuropsychologists, how can we use our expertise to empirically inform public health policy? The diagnosis and treatment of post-acute sequelae of COVID-19, the identification and characterization of post-pandemic educational setbacks, and the adaptation of new technological and diagnostic advances into clinical practice workflows represent a vital set of new challenges and opportunities poised to disrupt traditional modes of practice. The articles in this special issue convey the role of neuropsychology in addressing these emerging issues and illustrate how and why neuropsychology is well positioned to be at the forefront of clinical practice and scientific advancements.
Production of docosahexaenoic acid by a novel isolated Aurantiochytrium sp. 6-2 using fermented defatted soybean as a nitrogen source for sustainable fish feed development
Authors: Ip Chi-Hei , Higuchi Hibiki , Wu Chang-Yu , Okuda Tomoyo , Katsuya Shohei , Ogawa Jun , Ando Akinori 
Published: March 2024

Abstract
We focused on the production of docosahexaenoic acid (DHA)-containing microbial lipids by Aurantiochytrium sp. using of defatted soybean (DS) as a nitrogen source. Defatted soybean is a plant biomass that could provide a sustainable supply at a low cost. Results showed that Aurantiochytrium sp. could not directly assimilate the DS as a nitrogen source but could grow well in a medium containing DS fermented with rice malt. When cultivated in a fermented DS (FDS) medium, Aurantiochytrium sp. showed vigorous growth with the addition of sufficient sulfate and chloride ions as inorganic nutrients without seawater salt. A novel isolated Aurantiochytrium sp. 6-2 showed 15.8 ± 3.4 g/L DHA productivity (in 54.8 ± 12.1 g/L total fatty acid production) in 1 L of the FDS medium. Therefore, DHA produced by Aurantiochytrium sp. using FDS enables a stable and sustainable DHA supply and could be an alternative source of natural DHA derived from fish oil.
Morphological and molecular data combined reveal inter- and intraspecific cranial shape variations in bats of Artibeus Leach, 1821 (Chiroptera: Phyllostomidae)
Authors: Mendes Samira Brito , Stefanello Fabiano , Costa Cleison Luís da Silva , Lima Amanda Cristiny da Silva , Olímpio Ana Priscila Medeiros , Pires Walna Micaelle de Morais , Fraga Elmary da Costa , Barros Maria Claudene 
Published: March 2024

Abstract
Since morphological traits may overlap among species within a complex, the integration of morphological and mitochondrial data could provide crucial insights for distinguishing species, as observed in fruit-eating bats of the genus Artibeus. Therefore, the application of geometric morphometric (GM) techniques could yield more refined and robust analyses of inter- and intraspecific variations. In this study, we generated two datasets: one with molecular delimitation data based on the barcode region (COI) and the other with cranial size and shape data using GM methods. Our aims were to investigate variations between large and small species within the genus Artibeus, as well as to explore potential factors influencing such variations. The results from species delimitation revealed molecular operational taxonomic units (MOTUs) supporting the morphological identification. Analyses using GM techniques demonstrated significant inter- and intraspecific variations in cranial size and shape among Artibeus species. The combined outcomes suggest the absence of a significant phylogenetic signal influencing skull variation. This scenario indicates that potential historical ecological factors may have directly influenced the cranial morphology of these species, acting as significant selection forces in geographical space and generating intraspecific variations in Artibeus planirostris.
Protocol for preliminary, multicenteric validation of “PoCOsteo device”: A point of care tool for proteomic and genomic study of osteoporosis
Authors: Razi Farideh , Ostovar Afshin , Fahimfar Noushin , M. Amoli Mahsa , Fana Saeed Ebrahimi , Dimai Hans Peter , Obermayer-Pietsch Barbara , Luegger Barbara , Rivadeneira Fernando , Nabipour Iraj , Larijani Bagher , Khashayar Patricia 
Published: March 2024

Abstract
One of the goals of the HORIZON 2020 project PoCOsteo was to develop a medical device, which would measure and/or quantify proteomic as well as genomic factors as present in whole blood samples collected through finger prick. After validating the tool in the clinical setting, the next step would be its clinical validation based on the existing guidelines. This article presents the protocol of a validation study to be carried out independently at two different centers (Division of Endocrinology and Diabetology at the Medical University of Graz as a clinic-based cohort, and the Endocrinology and Metabolism Research Institute at the Tehran University of Medical Sciences as a population-based cohort). It aims to assess the tool according to the Clinical & Laboratory Standards Institute guidelines, confirming if the proteomics and genomics measurements provided by the tool are accurate and reproducible compared with the existing state-of-the-art tests. This is the first time that such a detailed protocol for lab validation of a medical tool for proteomics and genomic measurement is designed based on the existing guidelines and thus could be used as a template for clinical validation of future point-of-care tools. Moreover, the multicentric cohort design will allow the study of a large number of diverse individuals, which will improve the validity and generalizability of the results for different settings.
An optimized protocol for generating appendage-bearing skin organoids from human-induced pluripotent stem cells
Authors: Ahmed Imaan , Sun Jane , Brown Jason , Khosrotehrani Kiarash , Shafiee Abbas 
Published: March 2024

Abstract
Organoid generation from pluripotent stem cells is a cutting-edge technique that has created new possibilities for modelling human organs in vitro, as well as opening avenues for regenerative medicine. Here, we present a protocol for generating skin organoids (SKOs) from human-induced pluripotent stem cells (hiPSCs) via direct embryoid body formation. This method provides a consistent start point for hiPSC differentiation, resulting in SKOs with complex skin architecture and appendages (e.g. hair follicles, sebaceous glands, etc.) across hiPSC lines from two different somatic sources.
Familialization of the ‘deviant’: a hindrance to queer community building?
Authors: Chakrabarti Pritha 
Published: March 2024

Abstract
Familial acceptance of queer relationships has long been at the centre of the same-sex marriage discourse in India. This is no coincidence since in India family as an institution represents caste, religious, class and other social privileges. Developing on Bordieu’s work on family, this paper examines three Hindi films—Ek Ladki Ko Dekha To Aisa Laga (2019), Shubh Mangal Zaada Savdhaan (2020) and Badhaai Do (2022)—to formulate the ‘ideology of familialization’ as the basis of the queer narratives in these popular film texts. Through narrative analysis of these texts, this paper argues that these narratives function at two levels: one, at the level of inducting the erstwhile subjects of developmentalist economy into the neoliberal economy; and two, they selectively transform the familial space of these subjects to make it conducive to integrate LGBTQ persons. The narratives perpetuate a consensus about the importance of selective co-option of queer individuals within the socially dominant traditional families, to keep the cycle of social privilege undisturbed by producing what Bordieu calls ‘unproblematic inheritors’. This, I argue, prevents the individual queer characters from building a modern queer community, a radical collective with intersectional politics at its heart, at the cost of alienating those who do not come from such caste/class privilege. This serves the interest of both the neoliberal market/State and the Hindu upper caste dominated social, perpetuating the Ideology of Familialization which eventually has the power to function as a governmental tool of transforming the ‘deviant’ lovers into ‘model’ queer citizens.
A Theory of Small Campaign Contributions
Authors: Bouton Laurent , Castanheira Micael , Drazen Allan 
Published: March 2024

Abstract
Popular and academic discussions have mostly concentrated on large donors, even though small donors are a major source of financing for political campaigns. We propose a theory of small donors with a key novelty: it centres on the interactions between small donors and the parties’ fundraising strategy. In equilibrium, parties micro-target donors with a higher contribution potential (that is, richer and with more intense preferences) and increase their total fundraising effort in close races. The parties’ strategic fundraising amplifies the effect of income on contributions, and leads to closeness, underdog and bandwagon effects. We then study the welfare effects of a number of common campaign finance laws. We find that, due to equilibrium effects, those tools may produce outcomes opposite to intended objectives. Finally, we identify a tax-and-subsidy scheme that mutes the effect of income while still allowing donors to voice the intensity of their support.
Speculum self-insertion: an alternative method for gynaecological examination?
Authors: Veto Marie-Morgane , Chazalon Julie , Atallah-Seive Corinne , Charles Rodolphe , Savall Angélique 
Published: March 2024

Abstract

Background
Speculum examination is an intrusive practice in the clinical care of women. It requires privacy and patients may experience discomfort or anxiety related to the procedure, which can result in delays or avoidance of necessary healthcare. Speculum self-insertion originated in the United States in the 1970s as part of the self-help movement. However, this clinical practice is largely unknown among healthcare providers and has rarely been assessed.

Aim
This study investigates the women’s views and healthcare providers’ experiences of the self-insertion method.

Method
A qualitative study was conducted between December 2021 and October 2022, including fieldwork combining semi-structured interviews (10 women) and focus groups associated with individual interviews of 13 healthcare providers. The data collected were independently coded by 2 authors and analysed using an inductive approach and grounded theory method.

Results
Speculum self-insertion was described as a way to decrease discomfort and facilitate speculum insertion. Self-insertion was proposed as a means of allowing women to participate in the examination, reducing their vulnerability against power imbalances in the doctor–patient relationship. Both patients and healthcare providers have reported that speculum self-insertion is a method that can contribute to improving trust and communication during the examination.

Conclusion
The practice of speculum self-insertion during the consultation is an alternative to traditional practitioner insertion and may be offered to all women by any practitioner who wishes to use this technique.
Genome analysis and biogeographic distribution of the earliest divergent Frankia clade in the southern hemisphere
Authors: Berckx Fede , Wibberg Daniel , Brachmann Andreas , Morrison Ciara , Obaid Nadia B , Blom Jochen , Kalinowski Jörn , Wall Luis G , Pawlowski Katharina 
Published: March 2024

Abstract
Coriariaceae are a small plant family of 14–17 species and subspecies that currently have a global but disjunct distribution. All species can form root nodules in symbiosis with diazotrophic Frankia cluster-2 strains, which form the earliest divergent symbiotic clade within this bacterial genus. Studies on Frankia cluster-2 mostly have focused on strains occurring in the northern hemisphere. Except for one strain from Papua New Guinea, namely Candidatus Frankia meridionalis Cppng1, no complete genome of Frankia associated with Coriaria occurring in the southern hemisphere has been published thus far, yet the majority of the Coriariaceae species occur here. We present field sampling data of novel Frankia cluster-2 strains, representing two novel species, which are associated with Coriaria arborea and Coriaria sarmentosa in New Zealand, and with Coriaria ruscifolia in Patagonia (Argentina), in addition to identifying Ca. F. meridionalis present in New Zealand. The novel Frankia species were found to be closely related to both Ca. F. meridionalis, and a Frankia species occurring in the Philippines, Taiwan, and Japan. Our data suggest that the different Frankia cluster-2 species diverged early after becoming symbiotic circa 100 million years ago.
Real-world evidence: Risdiplam in a patient with spinal muscular atrophy type I with a novel splicing mutation and one SMN2 copy
Authors: Ma Kai , Zhang Kaihui , Chen Defang , Wang Chuan , Abdalla Mohnad , Zhang Haozheng , Tian Rujin , Liu Yang , Song Li , Zhang Xinyi , Liu Fangfang , Liu Guohua , Wang Dong 
Published: March 2024

Abstract
Spinal muscular atrophy (SMA), which results from the deletion or/and mutation in the SMN1 gene, is an autosomal recessive neuromuscular disorder that leads to weakness and muscle atrophy. SMN2 is a paralogous gene of SMN1. SMN2 copy number affects the severity of SMA, but its role in patients treated with disease modifying therapies is unclear. The most appropriate individualized treatment for SMA has not yet been determined. Here, we reported a case of SMA type I with normal breathing and swallowing function. We genetically confirmed that this patient had a compound heterozygous variant: one deleted SMN1 allele and a novel splice mutation c.628-3T&gt;G in the retained allele, with one SMN2 copy. Patient-derived sequencing of 4 SMN1 cDNA clones showed that this intronic single transversion mutation results in an alternative exon (e)5 3′ splice site, which leads to an additional 2 nucleotides (AG) at the 5′ end of e5, thereby explaining why the patient with only one copy of SMN2 had a mild clinical phenotype. Additionally, a minigene assay of wild type and mutant SMN1 in HEK293T cells also demonstrated that this transversion mutation induced e5 skipping. Considering treatment cost and goals of avoiding pain caused by injections and starting treatment as early as possible, risdiplam was prescribed for this patient. However, the patient showed remarkable clinical improvements after treatment with risdiplam for 7 months despite carrying only one copy of SMN2. This study is the first report on the treatment of risdiplam in a patient with one SMN2 copy in a real-world setting. These findings expand the mutation spectrum of SMA and provide accurate genetic counseling information, as well as clarify the molecular mechanism of careful genotype–phenotype correlation of the patient.
Continuous Monitoring of CRP, IL-6, and Calprotectin in Inflammatory Bowel Disease Using a Perspiration-Based Wearable Device
Authors: Shahub Sarah , Kumar Ruchita Mahesh , Lin Kai-Chun , Banga Ivneet , Choi Natalie K , Garcia Nicole M , Muthukumar Sriram , Rubin David T , Prasad Shalini 
Published: March 2024

Abstract

Background
Wearable sensor devices represent a noninvasive technology to continuously track biomarkers linked to inflammatory bowel disease (IBD). We assessed the inflammatory markers associated with IBD in human perspiration.

Methods
Participants with IBD were monitored for 40 to 130 minutes with a proprietary wearable sensor device used to measure C-reactive protein, interleukin-6, and calprotectin. Sensor response using electrochemical impedance spectroscopy and serum samples were measured on the same day. The Mann-Whitney test was used to analyze the relationship between active and remission IBD in serum and perspiration, classified according to endoscopic reports and serum biomarker levels. Asynchronously collected fecal calprotectin from a subset of the population was similarly analyzed.

Results
A total of 33 subjects were enrolled. Expression of calprotectin was significantly elevated in the active cohort compared with the remission cohort in perspiration (P &lt; .05; median = 906.69 ng/mL; active 95% confidence interval [CI], 466.0-1833 ng/mL; remission 95% CI, 328.4-950.8 ng/mL), serum (median = 1860.82 ng/mL; active 95% CI, 1705-2985 ng/mL; remission 95% CI, 870.2-1786 ng/mL), and stool (P &lt; .05; median = 126.74 µg/g; active 95% CI, 77.08-347.1 µg/g; remission 95% CI, 5.038-190.4 µg/g). Expression of CRP in perspiration and serum was comparable between the active and remission cohorts (perspiration: P &gt; .05; median = 970.83 pg/mL; active 95% CI, 908.7-992 pg/mL; remission 95% CI, 903.3-991.9 pg/mL; serum: median = 2.34 µg/mL; active 95% CI, 1.267-4.492 µg/mL; remission 95% CI, 1.648-4.287 µg/mL). Expression of interleukin-6 in perspiration was nonsignificant in the active cohort compared with the remission cohort and was significantly elevated in serum (perspiration: P &lt; .05; median = 2.13 pg/mL; active 95% CI, 2.124-2.44 pg/mL; remission 95% CI, 1.661-2.451 pg/mL; serum: median = 1.15 pg/mL; active 95% CI, 1.549-3.964 pg/mL; remission 95% CI, 0.4301-1.257 pg/mL). Analysis of the linear relationship between perspiration and serum calprotectin (R2 = 0.7195), C-reactive protein (R2 = 0.615), and interleukin-6 (R2 = 0.5411) demonstrated a strong to moderate relationship across mediums.

Conclusions
We demonstrate the clinical utility of perspiration as a noninvasive medium for continuous measurement of inflammatory markers in IBD and find that the measures correlate with serum and stool markers across a range of disease activity.