bluuebunny/crossref_metadata_2025_split huggingface dataset:
HEMODYNAMICS CHANGES IN CHILDREN WITH SEPSIS
Authors: Shadrin V.O. , Yevtushenko V.V. 
Published: April 2024

Sepsis is one of the most common causes of mortality in children. The severe course of sepsis is usually associated with the development of septic shock and multiple organ failure. An important component in the comprehensive examination and evaluation of treatment effectiveness is the monitoring of hemodynamic parameters. We aimed to evaluate changes in central and peripheral hemodynamics by echocardiography and doppler ultrasound in children with sepsis.
Material and methods. A retrospective study of cases of septic shock in children aged 0 to 18 years who underwent treatment in the intensive care unit was conducted. Patients were monitored for central and peripheral hemodynamics by echocardiography and doppler ultrasound.
Results. 108 cases of sepsis were investigated. Meningococcus was an etiological factor in 53,7% patients, 0.9% – Staphylococcus, 0.9% – Pneumococcus, 0,9% – Yersinia, and in 41,7% aetiology was not been established. In 12 children from the study group fatal outcome was occurred. Septic shock development was associated with significantly higher rates of heart rate (HR) and an increase in peripheral resistance (RI) indices in the abdominal trunk and renal arteries. Fatal course of the disease was associated with a high rate of heart rate and a decrease in diastolic velocity (V min) in the abdominal trunk and renal arteries.
Conclusion. Echocardiography and ultrasound dopplerography in children with sepsis are the useful tools to evaluate the pattern and extent of cardiovascular dysfunction.
Results of regional blood flow assessment can be a diagnostic criterion for the septic shock and has prognostic value in children with sepsis.
MINI-INVASIVE (PUNCTURE-DRAINING) ECHO-CONTROLLED INTERVENTIONS IN THE PATHOLOGY OF THE ABDOMINAL CAVITY
Authors: Kolosovych A.I. , Sydorenko R.A. , Tsyganok A.M. 
Published: April 2024

Puncture-draining interventions under the ultrasound control have become an indispensable effective aid in complex treatment, and in some cases, an independent method of correcting a number of diseases of the abdominal cavity. However, some technological aspects in the execution of the procedure and the postoperative management of patients are left out of the focus of discussion.
The aim – to improve the results of the use of puncture drainages under ultrasound control in abdominal pathology.
Puncture-draining interventions are applied in 89 patients: with pancreatogenic fluid collections, intra-abdominal complications after abdominal operations, inflammatory processes in the gallbladder, tumor bile duct obstructions, liver abscesses.
An analysis of the effectiveness of the use of puncture and drainage interventions under ultrasound control in pathology of the abdominal cavity organs and retroperitoneal space was carried out.
Puncture-draining interventions under ultrasound control are an alternative to open surgical interventions, especially in patients with severe concomitant pathology, severe general condition. In this case, they can be as element (stage) of complex treatment and an independent, final method of surgical care. The choice of echo-controlled interventional technologies as a method of operational correction should be carried out with understanding their capabilities. The effectiveness of such mini-invasive methods allows us to recommend their acceptance in surgical hospitals for diseases of the abdominal cavity organs and retroperitoneal space.
THE ROLE OF THE RATIO OF TAURIN / ALANIN AS A PREDICTOR OF THE EFFICIENCY OF MEDICAMENTOUS CORRECTION OF CARDIAC RHYTHM DISORDERS IN POSTINFARCT PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Belikova J. 
Published: April 2024

The aim: Determine the predictor quality of the taurine / alanine ratio (Tau / Ala) in predicting the antiarrhythmic activity of taurine (TN) and meldonium (ME) in patients with post-infarction cardiosclerosis (PIC) and diabetes mellitus type 2 (T2DM).
Materials and Methods 92 patients were examined with PICS and T2DM, which were divided into two groups: main (MG), (n = 62): 34 women and 28 men, the median age of the patients was 65.4 years (interquartile interval (II) – 61 -69 years), and the control group (CG) (n = 30): 17 women and 13 men, the median age – 64.6 years (II 64-67 years). CG patients took only basic therapy (BT) preparations of PICS and T2DM. In order to study the complex and isolated effect of TN and ME, the MG was divided into 3 subgroups (SG) in accordance with the additional treatment to BT. Amino acids and the ratios between them were determined. According to the results of Holter ECG monitoring (HECM), heart rate disorders (HRD) was evaluated.
Results: It was revealed that the effectiveness of treatment depends (p <0.05 by the Chi-square criteria) on the chosen treatment method. It was established that the combined use of TN and ME in patients SG 3 leads to a pronounced decrease in ventricular arrhythmia (VE) compared with CG (p = 0.02). There were no statistically significant differences in the effectiveness of treatment in the MG subgroups between themselves, and SG 1 and SG 2 from the CG were not detected (p = 0.49, p = 0.47 and p = 0.64, respectively). Against the background of the treatment, a significant increase in Tau / Ala in all subgroups was recorded.
Conclusion The use of ME and TN for 12 weeks in patients with PICS with T2DM has a positive effect on the HRD and AMA values of the blood spectrum. The serum Tau / Ala ratio is a highly sensitive and highly specific predictor of the response to the drug correction of HRV in patients with PICS and T2DM.
HYGIENIC ASSESSMENT OF LOW-CARBOHYDRATE DIET’S INFLUENCE ON THE NUTRITIONAL STATUS OF THE STUDENT
Authors: Herasymenko S.V. , Blagaia A.V. , Zinchenko T.I. 
Published: April 2024

The effect of low-carbohydrate diets on the nutritional status of human has been studied.
The aim of the work was the hygienic assessment of the effect of low-carbohydrate diet on the student’s nutritional status.
Materials and methods. The analysis of the nutrient composition of the four diets was carried out and the dynamics of the student’s body mass over the observation period were studied.
Results. Findings indicate reduced amounts of fats and carbohydrates content in proposed diets, as well as a decrease in the level of micronutrients such as Ca, however, the amount of Mg, P, K, Fe and some vitamins were increased. The energy value of the rations was below daily needs by almost 5 times. The positive dynamics of the student’s body weight reduction for the period from 07/30/2018 to 08/22/2018 was revealed. It is determined that the fat content, incl. visceral, during the study period decreased. A decrease in chest, waist, abdomen and hips circumferences was also noted.
Conclusions. The results obtained allowed to establish that a temporary low-carbohydrate diet has a positive effect on the nutritional status of a person with an increased body mass.
Impact of changes in the vaginal microbiome and chronic endometritis on the initiation of hyperplastic processes of the endometrium in women
Authors: Khaskhachykh Dmytro, , Potapov Valentin 
Published: April 2024

the article presents a review of the literature, which examines the impact of changes inthe vaginal microbiome and chronic endometritis on the development of hyperplastic processes of the
endometrium in women. Many studies have proven the undoubted role of these factors in the develop-ment of endometrial hyperplastic processes, such as atypical hyperplasia and endometrial polyposis.
Chronic endometritis, on the background of which there was a course of endometrial hyperplasia, in95.1% of women studied was caused by an infection of viral, bacterial or fungal origin. Numerous
studies indicate the important role of chronic persistent infection in the development of hyperprolif-erative processes of the endometrium. The largest role in the pathological process is probably played
by bacteria of the genus Gardnerella viridans as well as gram-positive cocci (Streptococcus). Herpes
simplex virus, cytomegalovirus, human papilloma virus and pathogenic fungi represented by the ge-nus Candida also influence the occurrence of this process. Further studies of the pathological action
of these microorganisms will achieve greater accuracy in the diagnosis of hyperplastic processes ofthe endometrium.
POTENSI ANURA DI DESA KINJIL PESISIR KABUPATEN KETAPANG SEBAGAI SUMBER BELAJAR BIOLOGI
Authors: Dilla Khastuti  , Setiadi Anandita Eka , Qurbaniah Mahwar 
Published: April 2024

Desa Kinjil Pesisir terletak di pesisir pantai yang memiliki 3 tipe habitat yang disukai Anura yaitu pemukiman, perkebunan, dan persawahan. Desa Kinjil Pesisir berdekatan dengan lingkungan sekolah sehingga dapat dimanfaatkan sebagai sumber belajar. Tujuan penelitian ini adalah mengkaji potensi anura yang ada di Desa Kinjil Pesisir kabupaten Ketapang, provinsi Kalimantan Barat, untuk dimanfaatkan sebagai sumber belajar biologi. Penenelitian dilakukan melalui 2 tahapan yaitu tahap I dilakukan inventarisasi dan identifikasi jenis anura Desa Kinjil Pesisir melalui melalui metode VES (Visual Ecounter Survey), dan tahap II melalui analisis angket potensi anura sebagai sumber belajar yang diisi oleh guru Biologi SMAN 2 Ketapang, SMAN 3 Ketapang, SMAN 4 Ketapang, SMA Muhammadiyah Ketapang, dan SMA Ma’arif Ketapang. Analisis data menggunakan metode deskriptif kualitatif. Hasil penelitian tahap I menemukan 12 individu anura dari 3 spesies yang ditemukan di 3 tipe habitat berbeda di Desa Kinjil Pesisir. Hasil penelitian tahap II menunjukan bahwa anura di desa Kinjil Pesisir berpotensi sebagai sumber belajar dan sesuai dengan submateri pokok kelas X, yaitu keanekaragaman hayati, klasifikasi mahluk hidup, ekologi,dan ruang lingkup biologi.
Recent Therapy to Treat Various Types of Cancer: An Overview
Authors: Kumar Amit , Kumar Rajesh , Pal Singh Ajeet , Singh Amar Pal 
Published: April 2024

Cancer is a fatal condition brought on by unchecked cellular growth. One of the gravest dangers to people worldwide is this. Both the incidence and mortality of cancer are rising. With their great benefits, particularly in the treatment of cancer, nanoparticles have revolutionized the globe. Conventional chemotherapy used to be the main treatment option for patients. Chemotherapeutics, however, also have several pharmacological drawbacks, including drug resistance, drug-drug interactions, water solubility, and stability. Reciprocally, dose-limiting toxicity is important, with non-specific toxicity to healthy cells, appetite loss, hair loss, peripheral neuropathy, vomiting, fatigued muscles, and diarrheal being the usual side effects. Drug delivery systems employ nanocarriers such as gold nanoparticles, high-density lipoprotein nanostructures, polymer nanoparticles, dendrimers, quantum dots, and nanodiamonds.
Keywords: Nanotechnology, Cancer, Drug delivery
The Relationship Between Work Posture and the Risk of Carpal Tunnel Syndrome in Openwork Craftsmen in the Village Mongolian
Authors: Adam Nurzihan , Febriyona Rona , Sudirman Andi Nur Aina 
Published: April 2024

Work posture is the posture of the body at the time of work. Different work attitudes will produce different strengths. When working, postures are designed to occur naturally, thereby reducing musculoskeletal injuries. The purpose of this study was to determine the relationship between work posture and the risk of carpal tunnel syndrome in openwork craftsmen in Mongolato Village, the type of research is quantitative with a cross-sectional approach, a population of 84 openwork craftsmen in Mongolato Village, a sample of 45 openwork craftsmen, which was determined by purposive sampling techniques, the statistical test used was Chi-Square, The research instrument is a questionnaire. The results showed that the work posture of the craftsmen could trigger the risk of carpal tunnel syndrome events and the results of chi-square analysis obtained p-value = 0.007>0.05. Based on the results of the analysis of 45 filigree craftsmen, it is known that craftsmen who have a work posture in the medium risk category totaled 27 respondents, with 20 respondents experiencing moderate carpal tunnel syndrome and 7 respondents experiencing high carpal tunnel syndrome. For craftsmen who have a high-risk work posture, there are 18 respondents, namely 6 respondents with moderate carpal tunnel syndrome and 12 respondents with high carpal tunnel syndrome. This study concludes that there is a relationship between work posture and the risk of carpal tunnel syndrome in filigree craftsmen. Advice for craftsmen to pay more attention to good work posture for work so that they can avoid the risk of carpal tunnel syndrome.
Analysis of the Needs and Development of Health Service Personnel at the Simalingkar Health Center in Medan City
Authors: Hasibuan Indah Doanita , Annisa Frety Salma , Ramadhani Rezeky Aulia , Aulia Cindy Monica , Sintia Dini 
Published: April 2024

The need and development of health service personnel as an integral part of health development is directed to meet the needs of the number and type of qualified health workers in providing all kinds of health service needs. This study aims to determine the needs of health workers both quantity and quality at the Simalingkar Health Center in Medan City. This research includes Descriptive Research with a qualitative approach, to find and obtain information about the analysis of energy needs at the Simalingkar Health Center in Medan City. The data and information obtained are then compared with the capabilities currently possessed with those expected for planning managers in the preparation of labor analysis of each work unit associated with the description and specifications of work at the Simalingkar Health Center in Medan City. The types of data used in this study are primary data and secondary data. Primary data are obtained through interviews and observations, while secondary data are obtained through tracing official records (documentation). The results showed that the preparation of health worker planning has been carried out so that the analysis of energy needs both in quantity and quality has been well planned. The number of health workers for the implementation of health services is quite sufficient at the Simalingkar Health Center in Medan City. Where health service personnel at Puskesmas have met the standards, or by the Minister of Health Regulation Number 75 of 2014. That way, the needs and development of health workers are well implemented.
Literary-social Interpretations of the ‘Stagnation’ Period in 20th Century Uzbek Literature
Authors: Inomovna Mirzaeva Zulkhumor 
Published: April 2024

The period from the 1960s to the 1980s under Brezhnev is stamped in history, both Soviet and Uzbek, as “stagnation.” Particularly for Uzbekistan, this period is known for such stigmatized events as the “cotton” or “Uzbek” scandal – the investigation into Uzbek First Party Secretary Sharaf Rashidov (1917-1983) for misrepresenting cotton harvest results during his twenty-four-year tenure – and the Afghan war (1979-1989). The experience of striving to save the nation from the aggressive system and stereotypes of society, from the "values" of slavery and subordination, is reflected in some examples of 20th-century Uzbek literature. The most prominent figures in XX Century’s Uzbek literary history, Said Ahmad (1920-2007) in his novel Silence (Jimjitlik, 1988) and O‘tkir Hoshimov (1941-2013) in Lives Passed in Dream (Tushda kechgan umrlar, 1992) fell apart from the literature written as the Soviet Union describes the events of this period through a prism of moral monikers. Their understanding of their place in the world has always been through their connection to the nation. Social anxiety for them is inextricably linked to artistic anxiety and vice versa. Writers took it upon themselves to unmask the sins associated with this period, such as “two-facedness” (qiyofasizlik), bribery, fraud, cruelty, and bloodthirstiness (in reference to the Afghan war). The novels focusing on the “stagnation” period played an important role in transforming these moral criticisms of Soviet rule into criticisms of Soviet rule as colonial exploitation and serve as an attempt to unmask the horrors and misdeeds behind Soviet officialdom that have long gone unnoticed. In this paper, I will examine some of those moral constructions and how they framed the period in the minds of post-Soviet Uzbeks. The literary interpretations of the problems in stagnation will be analyzed in the historical, cultural, political and literary context. I hope this paper contributes to the research carried out on Central Asian studies, including Uzbek Literature Literary history, which is known very little worldwide.
Studying the acids and amino acid composition of horse chestnut flowers
Authors: Chistyakova A. S. , Dunilin A. D. , Trineeva O. V. , Bolgov A. S. , Gudkova A. A. , Slivkin A. I. 
Published: April 2024

Introduction. Currently, there is an increasing trend towards assessing the full spectrum of chemical compounds in plant materials. One of the first steps in the formation of secondary metabolites of complex structure, participating in biochemical processes in the plant body, which have their own effect on the human and animal body, are organic acids (OA) and amino acids (AA). However, due attention is not always given to these compounds when studying the component composition of plant raw materials.Aim. The purpose of the work was to study the profile and quantitative assessment of the content of organic acids and amino acids of Aesculus hippocastanum L. flowers.Materials and methods. The object of the study were horse chestnut flowers, collected during flowering in the Voronezh region in 2021 and dried by air-shade method. Quantitative assessment of the amount of TC in terms of malic acid and ascorbic acid was carried out titrimetrically according to the methods presented in the State Pharmacopoeia of the Russian Federation, XIV edition. The composition of the OA and AA profiles of horse chestnut flowers was determined using the capillary electrophoresis method ("Kapel®-105/105M", Group of Companies "Lumex", Russia).Results and discussion. The method of capillary electrophoresis revealed the presence of 12 compounds of the OA group in a total amount of 4.7 % (in terms of absolutely dry raw materials). The rationality of recalculating the content of the sum of OA to the major component – citric acid, which amounted to 1.65 ± 0.04 %, was shown. The content of ascorbic acid was low (0.033 ± 0.007) %. Using the TLC method, the presence of 5 zones of compounds belonging to the AA class was established in the aqueous extract of horse chestnut flowers. The quantitative content of the sum of free AA in terms of glutamine, determined by the spectrophotometric method, was 2.25 ± 0.07 % (n = 5). The presence of 17 AA was determined by capillary electrophoresis, which amounted to 7.13 %. Glutamic acid is present in the greatest quantity in horse chestnut flowers (1.19 %). Essential amino acids amounted to 2.27 %; leucine was present in the predominant amount (0.58 %).Conclusion. A study was carried out of the qualitative composition and quantitative content of organic acids and amino acids of horse chestnut flowers. The composition of the profile and the quantitative content of organic acids and amino acids have been established. It was revealed that citric acid prevails in the total organic acids; glutamic, aspartic acid, arginine and proline are found in greater quantities in the total amino acids.
ANALISIS UNSUR CITRAAN PUISI â€œDI NEGERI AMPLOPâ€ KARYA KH. A. MUSTOFA BISRI
Authors: Nada Anwar , Hairunisa Hairunisa 
Published: April 2024

This research was conducted with the aim of explaining the elements of the poetry imageryâ€Di Negeri Amplopâ€ karya KH. A. Mustofa Bisri. The method used in this research is descriptive qualitative method. The data used are primary data and secondary data, data sources related to where the data obtained by the subject of this study are poetry texts. The data collection techniques used were observation and dokumentation. The data analysis tecnique used was data reduction, and conclusion. Based on the results of data analysis, it can be concluded that there are 7 images, namely; (1) visual images is an image generated by the sense of sight (eye), (2) auditory image is an image produced by mentioning or deciphering sound, (3) touch image is an image that chan be self by the sense of touch (skin), (4) olfactory imagery is an imagery related to the impression or image produced by the sense of smell, (5) tasting image is an image related to the impression or image produced by the sense of taste, and (6) feeling image is an expression of the poets by KH. A. Mustofa Bisri, there were 4 images obtained during the 5 days of the study, namely, (1) visual images, images created by the sense of sight (eyes), are explained about the conditions in this country which are made as materialistic countries or people who are concerned with power, property, money, etc. (2) hearing images produced by mentioning or describes the sound of a voice, which explains how cruel the ruler is who silences the mouths of people who want to convey the truth (3) motion images of something that seems to be moving, which explains the envelopeÂ referred to here is not containng a letter containing envelopes containing money, envelopes can move anywhere and for anyone (4) imagery of feelings, expression of feelings of the poet to express these feelings, explain the poet to express his frustation by using a subtle satire tone to a ruler who is greedy for power, what is right can be wong and wrong can be right with an envelope.
ENGLISH TEACHER’S STRATEGIES IN TEACHING STUDENTS WITH HEARING IMPAIRMENT AT SMP LUAR BIASA YPAC
Authors: Tambunal Mulkiah F.H. , Ismail Anwar 
Published: April 2024

This research aimed to identify English teachers’ strategies in teaching students with hearing impairment and the challenges which the teacher faced in classroom practices. The research method used is qualitative with a case study approach, The subject of this research was an English teacher at SMPLB YPAC. The data were collected by using observation checklist and interview. The result of research showed that there are two strategies used by teacher at SMPLB YPAC grade 8th, namely the manual method which has two basic components, namely sign language and finger spelling and the oral method, namely lip reading or speech reading. Implementing the strategy, there are challenges faced by teachers. The challenges are that first, students sometimes have difficulty understanding words and teachers sometimes need to repeat words or write them down. Second, the limited vocabulary of students and how to overcome them with the teacher needing to explain the definition and provide examples with the media. Third, the teacher did not push students to do exactly what the teacher says. Last, the need for repetition in delivering material with a long duration compared to regular students and the ability of the teacher to remain patient with students is very necessary in answering the last challenge.