bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significados que atribuyen jóvenes a malestar Social y bienestar Social
Authors: Cea-Leiva Fredy , Villagran Andrades Myriam , Denegri Coria † Marianela 
Published: March 2024

El presente artículo indaga los significados que estudiantes universitarios le otorgan a los conceptos de malestar y bienestar sociales. Para esta investigación el malestar social surge como consecuencias de la incertidumbre por la ausencia de estructuras que den sentido al actuar en sociedad; inseguridad por el aumento del riesgo de sociedades altamente fragmentadas; y desprotección por vivenciar lo social sin el otro, elementos todos, agudizados por un giro neoliberal de la sociedad.
La metodología del presente estudio fue cualitativa, transversal de tipo descriptiva/interpretativa, se usaron redes semánticas naturales, donde el estímulo fue malestar social y bienestar social. Participaron 147 estudiantes de tres universidades de Temuco-Chile, mediante un cuestionario en línea.
Los principales resultados fueron que el núcleo semántico para malestar social fue desigualdad, seguido de injusticia y para bienestar social fue tranquilidad, seguido de salud, educación y felicidad. No existen diferencias significativas entre hombres y mujeres para el significado de malestar, pero una leve diferencia para bienestar. Hay similitud en los núcleos entre aquellos estudiantes que se declararon de izquierda y aquellos que participaron de las movilizaciones y es distinto al núcleo de aquellos que se declararon de derecha y aquellos que no participaron de las movilizaciones.
Mental Health Education and Self-Reported Depressive Symptoms Among College Athletes
Authors: Lana Loken  , Anne Kelly  , Matt Moore  , Nambiro Woleson Dzimbiri Mastano , Bennett Payton 
Published: March 2024

Depression among college athletes is a subject of growing research interest. The time demands and performance-related pressures college athletes face increase the risk for possible mental health diagnoses. It is recommended college athletes receive training on mental health issues to learn about symptoms or identify early warning signs. This study investigated whether receiving or not receiving pre-sport mental health education influenced reported depressive symptoms of National Association of Intercollegiate Athletics (NAIA) college athletes. This quantitative, cross-sectional study included voluntary college athletes aged 18-years-old (n = 361). Most participants (n = 229, 63.7%) indicated they did not receive mental health training from their college or university prior to sport participation. A web-based instrument that consisted of a demographic questionnaire and Patient Health Questionnaire (PHQ-9) was used to identify college athletes who reported depressive symptoms. College athletes who did not receive pre-sport mental health training scored in a higher category of depression symptoms than college athletes who did receive mental health training. It is recommended college athletic programs explore the importance of mental health training sessions to prepare student-athletes to recognize and respond promptly and appropriately to mental health challenges.
Keywords: mental health literacy, college athletes, depression, NAIA
Skrining Kadar Glukosa Dan Edukasi Pola Makan Gizi Seimbang UntuK Pencegahan Pra Sindrom Metabolik pada Santriwati di PP Al Hidayah 2 Bangkalan
Authors: Kardina Rizki Nurmalya , Setiarsih Dini , Puspitasari Mia , Wulandari Catur , Sunaryo Merry , Na’ifah Audy , Siti Dinda 
Published: March 2024

Selama masa remaja seseorang akan mengalami pertumbuhan fisik yang sangat cepat yang sangat berpengaruh terhadap status gizi dan kesehatan. Salah satu pertumbuhan fisik pada remaja yaitu mengalami perubahan bentuk tubuh seperti ukuran tubuh yang diatas normal atau berlebih. Berdasarkan data prevalensi obesitas sentral di Indonesia semakin mengalami meningkat dari tahun ke tahun. . Obesitas merupakan merupakan salah satu penyakit tidak menular, dimana penyakit tidak menular ini bisa mengakibatkan sindrom metabolik. Untuk mencegah terjadinya sindrom metabolik maka pengabdian kepada masyarakat ini dilakukan untuk mencegah sindrom metabolik dengan melakukan skrining kadar glukosa darah. Pra sindrom metabolik ini untuk mencegah para responden bisa mengontrol kadar glukosa darahnya. Disamping skrining kadar glukosa darah dilakukan juga edukasi terkait dengan pola makan gizi seimbang. Pola makan dengan gizi seimbang akan disampaikan dengan media bookleat yang akan diberikan oleh responden, serta poster yang akan diletakkan di ruang kesehatan yang ada di pondok pesantrenMetode yang dilakukan adalah mengumpulkan responden diAula PP Al Hidayah 2 Bangkalan untuk dilakukan skrining kadar glukosa pengecekan kadar gula darah dan diberikan edukasi makanan gizi seimbang untuk mencegah terjadinya Pra sindrom metabolic. Edukasi disampaikan dengan cara pertemuan langsung pada responden dan di tempel di ruang UKS pondok pesantren dengan media yang digunakan untuk meningkatkatkan pemahaman dan pengetahuan terkait makanan gizi seimbang untuk mencegah penyakit pra sindrom metabolik adalah poster dan bookleat. Pengukuran pemahaman dan pengetahuan responden digunakan dengan menggunakan metode pre test dan post test. Hasil dari kegiatan pengabdian kepada masyarakat dengan responden santriwati 5 responden memiliki kadar glulkosa tinggi atau sering disebut diabetes (> 200 mg/dl) sedangkan 15 responden memiliki kadar glukosa pre diabetes (< 200 mg/dl). Pada responden yang memiliki kadar glukosa darah dibawah (< 200 mg/dl) memiliki pola makan yang cenderung mengkonsumsi makanan yang apa adanya yang di dapat di pondok pesantren. Responden yang memiliki glukosa darah dibawah rata rata sering mengkonsumsi sayuran saja Hasil penelitian menunjukkan rata-rata skor pretest sebesar 30,5. Nilai tersebut meningkat menjadi rata-rata 91,9 pada saat post-test
Pengembangan Potensi Lokal Daerah Melalui Pendaftaran Indikasi Geografis Untuk Memperkuat Potensi Ekonomi Masyarakat di DI Yogyakarta
Authors: Asri Dyah Permata Budi , Sriyono Edy 
Published: March 2024

Potensi lokal di Yogyakarta cukup berlimpah dan perlu pengelolaan yang serius guna menghasilkan manfaat ekonomi bagi masyarakat maupun daerah setempat. Salah satu bentuk pengelolaan potensi lokal adalah dengan pendaftaran Indikasi Geografis. Secara hukum, jika untuk produk dan kekayaan alam yang telah terdaftar secara resmi dan dikeluarkan sertifikat Indikasi Geografis oleh Direktorat Jenderal Kekayaan Intelektual Kementerian Hukum dan HAM RI, maka negara akan memberikan perlindungan atas Indikasi Geografis dari pelanggaran dan penyalahgunaan hak. Selama ini perlindungan hukum Hak Kekayaan Intelektual hanya sebatas membahas mengenai merek, untuk Indikasi Geografis belum banyak dibahas, sehingga perlu ada pemahaman sekaligus pendampingan bagi pemerintah daerah maupun masyarakat MPIG.Metode yang dipakai adalah dengan melakukan edukasi dan sosialisasi dan pendampingan dalam pendaftaran Indikasi Geografis. Khusus untuk IG Kopi Robusta Merapi Sleman juga diberikan edukasi dan sosialiasi mengenai irigasi yang efektif dan optimal lahan kopi melalui sistem irigasi tetes untuk keberlangsungkan perkebunan kopi di daerah tersebut karena disebabkan oleh minimnya ketersediaan air. Hasil yang diharapkan adalah terbangunnya kesadaran masyarakat dan pemerintah daerah akan arti pentingnya perlindungan IG dan pembuatan 2 buah buku Dokumen Deskripsi IG. Hasil pengabdian adalah dengan melakukan kegiatan sosialisasi pada dua wilayah yaitu Kabupaten Sleman dan Kabupaten Bantul serta pembuatan buku Dokumen Deskripsi IG. Kesimpulan dalam pengabdian ini adalah masyarakat dan pemerintah daerah telah memahami arti penting IG dan melakukan pendaftaran Indikasi Geografis Kopi Robusta Merapi dan Indikasi Geografis Gerabah Kasongan Bantul.
Identifikasi Dan Pengenalan Bahaya Di Lingkungan Kerja Pada Bengkel Las
Authors: Merry Sunaryo  , Moch. Sahri  , Ratna Ayu Ratriwardhani  , Farid Willy Kurnia  
Published: March 2024

Tempat kerja yaitu suatu tempat yang di dalamnya terdapat tenaga kerja yang bekerja atau linkungan yang sering dimasuki oleh tenaga kerja yang banyak pula bersinggungan dengan sumber-sumber bahaya. Tingginya kasus kecelakaan kerja menunjukkan bahwa masih kurangnya kesadaran tenaga kerja maupun perusahaan dalam penanganan masalah keselamatan kerja. Bengkel las merupakan salah satu tempat kerja di industri informal yang perlu perhatian dalam pelaksanaan K3 di tempat kerja. Oleh sebab itu perlunya di lakukan Identifikasi Dan Pengenalan Bahaya Di Lingkungan Kerja yang di lakukan Bengkel Las. Pelaksanaan Identifikasi Dan Pengenalan Bahaya Di Lingkungan Kerja yang di lakukan Bengkel Las di laksanakan di bengel las Jl. Jemur Ngawingan, kota Surabaya. Kegiatan memiliki sasaran utama adalah pekerja. Jumlah pekerja yang menjadi responden adalah dengan total 8 orang. Metode pelaksanaan yang dilakukan adalah identifikasi dan sosialisasi terkait risiko bahaya di tempat kerja, dengan menggunakan media poster. Pemahaman yang di berikan pada pekerja adalah Pengetahuan Mengenai K3, Pengetahuan Tentang risiko bahaya di tempat kerja, dan Pentingnya Pengguanaan APD (Alat Pelindung Diri). Terdapat peningkatan pengetahuan pekerja berdasarkan hasil pretest dan post test yang di lakukan. Sehingga Sebagian besar para pekerja memahami pentingnya penerapan K3, bahaya di lingkungan kerja, hingga pentingnya menggunakan APD (alat pelindung diri) yang sesuai. Untuk selanjutanya perlu dilakukan pememahaman lebih dalam mengenai K3 terutama dalam Kesehatan kerja. Para pekerja perlu lebih banyak mengetahui tentang faktor bahaya apa yang ada di lingkungan mereka bekerja dan bagaimana cara menanggulangi nya.
Pemberdayaan Kader Kesehatan dan Tutor sebaya stunting sebagai Upaya pencegahan stunting dan Pengelola Stunting Center
Authors: Elly Dwi Masita  , Uke Maharani Dewi  , Annif Munjidah  , Hinda Noviyanti  , Pratiwi hariyani Putri  , Heni Agustina  
Published: March 2024

Sampai saat ini, stunting pada anak usia 3 – 5 tahun merupakan masalah kesehatan anak terbesar yang dialami oleh sebagian besar negara berkembang termasuk Indonesia. Survey yang telah dilakukan pada bulan Januari 2023 bersama petugas kesehatan setempat bahwa dari 170 balita 30 mengalami gizi yang buruk berupa berat badan kurang sejumlah 18 balita dan 12 balita terindikasi stunting dengan orang tua yang memiliki status ekonomi rendah. Tujuan umum kegiatan ini terfokus pada pencapaian kemandirian kesehatan melalui mendirikan pusat informasi dan fasilitas tata laksana stunting yang dikelola oleh kader kesehatan sebagai upaya mencegah peningkatan prevalensi stunting sekaligus sebagai fasilitas peningkatan pendapatan keluarga yang memiliki anak dengan resiko masalah gizi, keluarga yang terindikasi stunting melalui stunting center. Metode kegiatan menggunakan pendekatan assasement based community development melalui seminar, pelatihan dan pendampingan. Instrumen menggunakan kuesioner dan cek list. Indikator ketercapaian adalah tingkat pengetahuan, tingakat ketrampilan dan pendapatan keluarga yang memiliki bayi dan balita beresiko terjadina gizi buruk dan stunting. Sasaran mitra adalah 55 kader kesehatan dan 55 ibu yang memiliki bayi dan balita yang berusia 5 tahun di wilayah Sidoarjo. Hasil dari kegiatan ini didapatkan adanya perbedaan mean pada masing- masing indikator capaian tingkat pengetahuan sebesar 66.6. ketrampilan pengelolaan bahan makanan sebesar 66.2, ketrampilan kewirausahaan berbasis kesehatan 64.3 serta pada indikator pendapatan keluarga sebesar 1.63 dan hasil uji mean whitney dengan sig= 0.001. Metode pendekatan assasement based community development melalui seminar, pelatihan dan pendampingan efektif dalam mengubah tingkat pengetahuan,persepsi dan perilaku kader kesehtan dan ibu- ibu yang memiliki bayi dan balita dalam pemenuhan gizi serta peningkatan ekonomi keluarga sebagai bentuk dukungan pada program penurunan stunting, ketahanan pangan keluarga sekaligus ketahanan ekonomi keluarga
Orbital shaking conditions augment human nasoseptal cartilage formation in 3D culture
Authors: Jovic Thomas Harry , Zhao Feihu , Jia Henry , Doak Shareen Heather , Whitaker Iain Stuart 
Published: March 2024

Introduction: This study aimed to determine whether a dynamic orbital shaking culture system could enhance the cartilage production and viability of bioengineered nasoseptal cartilage.Methods: Human nasal chondrocytes were seeded onto nanocellulose-alginate biomaterials and cultured in static or dynamic conditions for 14 days. Quantitative polymerase chain reaction for chondrogenic gene expression (type 2 collagen, aggrecan and SOX9) was performed, demonstrating a transient rise in SOX9 expression at 1 and 7 days of culture, followed by a rise at 7 and 14 days in Aggrecan (184.5-fold increase, p &lt; 0.0001) and Type 2 Collagen (226.3-fold increase, p = 0.049) expression. Samples were analysed histologically for glycosaminoglycan content using Alcian blue staining and demonstrated increased matrix formation in dynamic culture.Results: Superior cell viability was identified in the dynamic conditions through live-dead and alamarBlue assays. Computational analysis was used to determine the shear stress experienced by cells in the biomaterial in the dynamic conditions and found that the mechanical stimulation exerted was minimal (fluid shear stress &lt;0.02 mPa, fluid pressure &lt;48 Pa).Conclusion: We conclude that the use of an orbital shaking system exerts biologically relevant effects on bioengineered nasoseptal cartilage independently of the expected thresholds of mechanical stimulation, with implications for optimising future cartilage tissue engineering efforts.
The causal relationship between gut microbiota and biliary tract cancer: comprehensive bidirectional Mendelian randomization analysis
Authors: Wang Kui , Wang Suijian , Qin Xianzheng , Chen Yifei , Chen Yuhua , Wang Jiawei , Zhang Yao , Guo Qiang , Zhou Chunhua , Zou Duowu 
Published: March 2024

BackgroundGrowing evidence has shown that gut microbiome composition is associated with Biliary tract cancer (BTC), but the causality remains unknown. This study aimed to explore the causal relationship between gut microbiota and BTC, conduct an appraisal of the gut microbiome’s utility in facilitating the early diagnosis of BTC.MethodsWe acquired the summary data for Genome-wide Association Studies (GWAS) pertaining to BTC (418 cases and 159,201 controls) from the Biobank Japan (BBJ) database. Additionally, the GWAS summary data relevant to gut microbiota (N = 18,340) were sourced from the MiBioGen consortium. The primary methodology employed for the analysis consisted of Inverse Variance Weighting (IVW). Evaluations for sensitivity were carried out through the utilization of multiple statistical techniques, encompassing Cochrane’s Q test, the MR-Egger intercept evaluation, the global test of MR-PRESSO, and a leave-one-out methodological analysis. Ultimately, a reverse Mendelian Randomization analysis was conducted to assess the potential for reciprocal causality.ResultsThe outcomes derived from IVW substantiated that the presence of Family Streptococcaceae (OR = 0.44, P = 0.034), Family Veillonellaceae (OR = 0.46, P = 0.018), and Genus Dorea (OR = 0.29, P = 0.041) exerted a protective influence against BTC. Conversely, Class Lentisphaeria (OR = 2.21, P = 0.017), Genus Lachnospiraceae FCS020 Group (OR = 2.30, P = 0.013), and Order Victivallales (OR = 2.21, P = 0.017) were associated with an adverse impact. To assess any reverse causal effect, we used BTC as the exposure and the gut microbiota as the outcome, and this analysis revealed associations between BTC and five different types of gut microbiota. The sensitivity analysis disclosed an absence of empirical indicators for either heterogeneity or pleiotropy.ConclusionThis investigation represents the inaugural identification of indicative data supporting either beneficial or detrimental causal relationships between gut microbiota and the risk of BTC, as determined through the utilization of MR methodologies. These outcomes could hold significance for the formulation of individualized therapeutic strategies aimed at BTC prevention and survival enhancement.
Frozen elephant trunk versus conventional proximal repair of acute aortic dissection type I
Authors: Göbel Nora , Holder Simone , Hüther Franziska , Anguelov Yasemin , Bail Dorothee , Franke Ulrich 
Published: March 2024

ObjectiveThe extent of surgery and the role of the frozen elephant trunk (FET) for surgical repair of acute aortic dissection type I are still subjects of debate. The aim of the study is to evaluate the short- and long-term results of acute surgical repair of aortic dissection type I using the FET compared to standard proximal aortic repair.MethodsBetween October 2009 and December 2016, 172 patients underwent emergent surgery for acute type I aortic dissection at our center. Of these, n = 72 received a FET procedure, while the other 100 patients received a conventional proximal aortic repair. Results were compared between the two surgery groups. The primary endpoints included 30-day rates of mortality and neurologic deficit and follow-up rates of mortality and aortic-related reintervention.ResultsDemographic data were comparable between the groups, except for a higher proportion of men in the FET group (76.4% vs. 60.0%, p = 0.03). The median age was 62 years [IQR (20), p = 0.17], and the median log EuroSCORE was 38.6% [IQR (31.4), p = 0.21]. The mean follow-up time was 68.3 ± 33.8 months. Neither early (FET group 15.3% vs. proximal group 23.0%, p = 0.25) nor late (FET group 26.2% vs. proximal group 23.0%, p = 0.69) mortality showed significant differences between the groups. There were fewer strokes in the FET patients (FET group 2.8% vs. proximal group 11.0%, p = 0.04), and the rates of spinal cord injury were similar between the groups (FET group 4.2% vs. proximal group 2.0%, p = 0.41). Aortic-related reintervention rates did not differ between the groups (FET group 12.1% vs. proximal group 9.8%, p = 0.77).ConclusionEmergent FET repair for acute aortic dissection type I is safe and feasible when performed by experienced surgeons. The benefits of the FET procedure in the long term remain unclear. Prolonged follow-up data are needed.
Mulberry and Hippophae-based solid beverage promotes weight loss in rats by antagonizing white adipose tissue PPARγ and FGFR1 signaling
Authors: Zhou Xiao-Ting , Zhu An-Qi , Li Xiao-Min , Sun Ling-Yue , Yan Jian-Gang , Luo Nin , Chen Shi-Sheng , Huang Zebo , Mao Xin-Liang , Li Kun-Ping 
Published: March 2024

Obesity, a multifactorial disease with many complications, has become a global epidemic. Weight management, including dietary supplementation, has been confirmed to provide relevant health benefits. However, experimental evidence and mechanistic elucidation of dietary supplements in this regard are limited. Here, the weight loss efficacy of MHP, a commercial solid beverage consisting of mulberry leaf aqueous extract and Hippophae protein peptides, was evaluated in a high-fat high-fructose (HFF) diet-induced rat model of obesity. Body component analysis and histopathologic examination confirmed that MHP was effective to facilitate weight loss and adiposity decrease. Pathway enrichment analysis with differential metabolites generated by serum metabolomic profiling suggests that PPAR signal pathway was significantly altered when the rats were challenged by HFF diet but it was rectified after MHP intervention. RNA-Seq based transcriptome data also indicates that MHP intervention rectified the alterations of white adipose tissue mRNA expressions in HFF-induced obese rats. Integrated omics reveals that the efficacy of MHP against obesogenic adipogenesis was potentially associated with its regulation of PPARγ and FGFR1 signaling pathway. Collectively, our findings suggest that MHP could improve obesity, providing an insight into the use of MHP in body weight management.
Untranslated regions (UTRs) are a potential novel source of neoantigens for personalised immunotherapy
Authors: Sng Christopher C. T. , Kallor Ashwin Adrian , Simpson Benjamin S. , Bedran Georges , Alfaro Javier , Litchfield Kevin 
Published: March 2024

BackgroundNeoantigens, mutated tumour-specific antigens, are key targets of anti-tumour immunity during checkpoint inhibitor (CPI) treatment. Their identification is fundamental to designing neoantigen-directed therapy. Non-canonical neoantigens arising from the untranslated regions (UTR) of the genome are an overlooked source of immunogenic neoantigens. Here, we describe the landscape of UTR-derived neoantigens and release a computational tool, PrimeCUTR, to predict UTR neoantigens generated by start-gain and stop-loss mutations.MethodsWe applied PrimeCUTR to a whole genome sequencing dataset of pre-treatment tumour samples from CPI-treated patients (n = 341). Cancer immunopeptidomic datasets were interrogated to identify MHC class I presentation of UTR neoantigens.ResultsStart-gain neoantigens were predicted in 72.7% of patients, while stop-loss mutations were found in 19.3% of patients. While UTR neoantigens only accounted 2.6% of total predicted neoantigen burden, they contributed 12.4% of neoantigens with high dissimilarity to self-proteome. More start-gain neoantigens were found in CPI responders, but this relationship was not significant when correcting for tumour mutational burden. While most UTR neoantigens are private, we identified two recurrent start-gain mutations in melanoma. Using immunopeptidomic datasets, we identify two distinct MHC class I-presented UTR neoantigens: one from a recurrent start-gain mutation in melanoma, and one private to Jurkat cells.ConclusionPrimeCUTR is a novel tool which complements existing neoantigen discovery approaches and has potential to increase the detection yield of neoantigens in personalised therapeutics, particularly for neoantigens with high dissimilarity to self. Further studies are warranted to confirm the expression and immunogenicity of UTR neoantigens.
Heterozygous mutations in factor H aggravate pathological damage in a stable IgA deposition model induced by Lactobacillus casei cell wall extract
Authors: Li Jingyi , Dong Yaping , Chen Feifei , Yang Hongyu , Chen Pei , Li Hongyu , Shi Sufang , Zhou Xujie , Zhu Li , Zhang Yuemiao , Liu Lijun , Xie Xinfang , Yu Feng , Jin Jing , Lv Jicheng , Zhang Hong 
Published: March 2024

IntroductionActivation of complement through the alternative pathway (AP) has a key role in the pathogenesis of IgA nephropathy (IgAN). We previously showed, by intraperitoneal injection of Lactobacillus casei cell wall extract (LCWE), C57BL/6 mice develop mild kidney damage in association with glomerular IgA deposition. To further address complement activity in causing glomerular histological alterations as suggested in the pathogenesis of IgAN, here we used mice with factor H mutation (FHW/R) to render AP overactivation in conjunction with LCWE injection to stimulate intestinal production of IgA.MethodsDose response to LCWE were examined between two groups of FHW/R mice. Wild type (FHW/W) mice stimulated with LCWE were used as model control.ResultsThe FHW/R mice primed with high dose LCWE showed elevated IgA and IgA-IgG complex levels in serum. In addition to 100% positive rate of IgA and C3, they display elevated biomarkers of kidney dysfunction, coincided with severe pathological lesions, resembling those of IgAN. As compared to wild type controls stimulated by the same high dose LCWE, these FHW/R mice exhibited stronger complement activation in the kidney and in circulation.DiscussionThe new mouse model shares many disease features with IgAN. The severity of glomerular lesions and the decline of kidney functions are further aggravated through complement overactivation. The model may be a useful tool for preclinical evaluation of treatment response to complement-inhibitors.