bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in cognitive functioning in the year after hematopoietic stem cell transplantation
Authors: Jacobs Sheri R. , Small Brent J. , Booth‐Jones Margaret , Jacobsen Paul B. , Fields Karen K. 
Published: August 2007

AbstractBACKGROUND.The current study examined changes in multiple domains of cognitive functioning of hematopoietic stem cell transplantation (HSCT) candidates tested pretransplantation, 6 months posttransplantion, and 12 months posttransplantion.METHODS.Using a sequential longitudinal design, 476 patients were randomized to be tested at all 3 timepoints, at 6 and 12 months posttransplantion, or at only 12 months posttransplantion. Participants completed a comprehensive battery of neuropsychologic tests that indexed memory, psychomotor speed, attention, and executive functioning, and provided a total neuropsychologic performance score (TNP).RESULTS.The results indicate that performance on cognitive abilities, except for attention, significantly improved across the 1‐year follow‐up period after HSCT. Performance on the TNP and all cognitive domains was superior or equal to population normative values by the 12‐month measurement point. The results also indicate that repeated exposure to tests led to better performance on motor speed and the TNP and that attrition influenced the TNP, such that those who remained in the longitudinal sample exhibited greater longitudinal improvement in scores as compared with patients who left the sample.CONCLUSIONS.The findings of the current study suggest that although patients undergoing HSCT experience cognitive deficits during the period just before transplantion, cognitive functioning returns to normative values within a year after transplantion. Cancer 2007. © 2007 American Cancer Society.
Automatic capture and efficient storage of e‐Science experiment provenance
Authors: Barga Roger S. , Digiampietri Luciano A. 
Published: August 2007

AbstractFor the first provenance challenge, we introduce a layered model to represent workflow provenance that allows navigation from an abstract model of the experiment to instance data collected during a specific experiment run. We outline modest extensions to a commercial workflow engine so it will automatically capture provenance at workflow runtime. We also present an approach to store this provenance data in a relational database. Finally, we demonstrate how core provenance queries in the challenge can be expressed in SQL and discuss the merits of our layered representation. Copyright © 2007 John Wiley & Sons, Ltd.
Hypophosphorylated TCR/CD3ζ signals through a Grb2‐SOS1‐Ras pathway in Lck knockdown cells
Authors: Methi Trond , Ngai Jacob , Vang Torkel , Torgersen Knut M. , Taskén Kjetil 
Published: August 2007

AbstractDespite the loss of proximal TCR‐dependent signaling events, downstream T cell responses are paradoxically augmented in T cells with siRNA‐mediated Lck knockdown (Methi et al., J. Immunol. 2005. 175: 7398–7406). This indicates that alternative Lck‐independent pathways of T cell activation exist or that low levels of Lck elicit other signals than normal T cell activation. Here we report the recruitment of Grb2‐SOS1 to CD3ζ of the TCR complex after prolonged anti‐CD3 (OKT3) stimulation in T cells with Lck knockdown. Grb2 bound to incompletely phosphorylated ITAM1 with the pY‐Y configuration in a solid‐phase assay, but was excluded by ZAP‐70 in the doubly phosphorylated pY‐pY conformation. Ras and ERK1/2 activation was augmented after prolonged stimulation in T cells with Lck knockdown compared to control, leading to increased activation of the proximal IL‐2 promoter (NFAT‐AP‐1). Finally, the phosphorylation of Ras‐GAP was strongly suppressed in Lck knockdown cells, indicating that a Ras negative feedback mechanism is dependent on Lck.
γc cytokines provide multiple homeostatic signals to naive CD4+ T cells
Authors: Masse Guillemette X. , Corcuff Erwan , Decaluwe Hélène , Bommhardt Ursula , Lantz Olivier , Buer Jan , Di Santo James P. 
Published: August 2007

AbstractCytokines signaling through receptors sharing the common γ chain (γc), including IL‐2, IL‐4, IL‐7, IL‐9, IL‐15 and IL‐21, are critical for the generation and peripheral homeostasis of B, T and NK cells. To identify unique or redundant roles for γc cytokines in naive CD4+ T cells, we compared monoclonal populations of CD4+ T cells from TCR‐Tg mice that were γ, γ, CD127–/– or CD122–/–. We found that γ naive CD4+ T cells failed to accumulate in the peripheral lymphoid organs and the few remaining cells were characterized by small size, decreased expression of MHC class I and enhanced apoptosis. By over‐expressing human Bcl‐2, peripheral naive CD4+ T cells that lack γc could be rescued. Bcl‐2+ γ CD4+ T cells demonstrated enhanced survival characteristics in vivo and in vitro, and could proliferate normally in vitro in response to antigen. Nevertheless, Bcl‐2+ γ CD4+ T cells remained small in size, and this phenotype was not corrected by enforced expression of an activated protein kinase B. We conclude that γc cytokines (primarily but not exclusively IL‐7) provide Bcl‐2‐dependent as well as Bcl‐2‐independent signals to maintain the phenotype and homeostasis of the peripheral naive CD4+ T cell pool.See accompanying commentary: http://dx.doi.org/10.1002/eji.200737721
PD‐L2 expression extends beyond dendritic cells/macrophages to B1 cells enriched for VH11/VH12 and phosphatidylcholine binding
Authors: Zhong Xuemei , Tumang Joseph R. , Gao Wenda , Bai Chunyan , Rothstein Thomas L. 
Published: August 2007

AbstractB1 B cells are the major source of natural antibody that is essential for innate immunity. The B1 repertoire is skewed toward production of phosphatidylcholine (PtC)‐binding VH11 and VH12 immunoglobulin that plays a key role in immune defense against bacterial infection. Programmed death‐ligand 2 (PD‐L2) is a ligand for the immunosuppressive receptor programmed death‐1 (PD‐1). It has been reported that expression of PD‐L2 is restricted to dendritic cells and macrophages in mice. Here we show that 50–70% of resting peritoneal B1 cells express PD‐L2, which is not present or inducible on conventional B2 B cells or PD‐L2– B1 cells. Although PD‐L2+ and PD‐L2– B1 cells are similar in proliferative responses and spontaneous immunoglobulin secretion, PD‐L2+ B1 cells are highly enriched for expression of VH11 and VH12 genes and encompass the bulk of PtC‐binding B1 cells. These findings extend the range of known PD‐L2 expression to B cells and show that B1 cells identified by this marker express a specific repertoire associated with anti‐bacterial immunity.
Nickel Complexes with N2O Donor Ligands: Syntheses, Structures, Catalysis and Magnetic Studies
Authors: Chakraborty Jishnunil , Nandi Mahasweta , Mayer‐Figge Heike , Sheldrick William S. , Sorace Lorenzo , Bhaumik Asim , Banerjee Pradyot 
Published: August 2007

AbstractTwo new terephthalato‐bridged tetranuclear polymeric NiII complexes, namely [Ni4L41(μ‐tp‐κ4‐O)(H2O)2(μ‐tp‐κ2‐O)]·2C2H5OH·CH3OH·3H2O (1) and [Ni4L42(μ‐tp‐κ4‐O)(H2O)2(μ‐tp‐κ2‐O)]·3H2O (2) [L1 = N‐(3‐aminopropyl)‐5‐bromosalicylaldimine and L2 = N‐(3‐aminopropyl)salicylaldimine], are reported along with the syntheses and structures of the dicyanoargentate‐bridged polymeric complexes [Ni(L1)(H2O){Ag(CN)2}]α (3) and [Ni(L3)(MeOH){Ag(CN)2}]α (4) [L3 = N‐(3‐amino‐2,2‐dimethylpropyl)‐5‐bromosalicylaldimine]. All four complexes are found to be effective heterogeneous catalysts for the epoxidation of alkenes such as styrene, α‐methylstyrene and cyclohexene in the presence of tert‐butyl hydroperoxide. The variable‐temperature magnetic susceptibility measurements (300–2 K) of complex 1 show a fair degree of antiferromagnetic coupling between the NiII centers.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Facile Synthesis of Flexible Bis(pyrazol‐1‐yl)alkane and Related Ligands in a Superbasic Medium
Authors: Potapov Andrei S. , Domina Galina A. , Khlebnikov Andrei I. , Ogorodnikov Vladimir D. 
Published: August 2007

AbstractFlexible ligands 1,3‐bis(pyrazol‐1‐yl)propanes, bis[2‐(pyrazol‐1‐yl)ethyl] ethers, and bis[2‐(3,5‐dimethylpyrazol‐1‐yl)ethyl]amine were prepared by a facile procedure involving the reaction of pyrazoles with 1,3‐dibromopropane, bis(2‐chloroethyl) ether or bis(2‐chloroethyl)amine hydrochloride in a superbasic medium (dimethyl sulfoxide/potassium hydroxide). Reaction of bis(2‐chloroethyl)amine and pyrazole unexpectedly led to 1,4‐bis[2‐(pyrazol‐1‐yl)ethyl]piperazine. The corresponding 4,4′‐diiodo‐substituted bis(pyrazole) derivatives were prepared by oxidative iodination with I2/HIO3/H2SO4 in acetic acid. Vilsmeier–Haak formylation of some of the prepared compounds yielded the corresponding dialdehydes.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Basic Ionic Liquids: Facile Solvents for Carbon–Carbon Bond Formation Reactions and Ready Access to Palladium Nanoparticles
Authors: Ye Chengfeng , Xiao Ji‐Chang , Twamley Brendan , LaLonde Aaron D. , Grant Norton M. , Shreeve Jean'ne M. 
Published: August 2007

AbstractA basic ionic liquid was selected to serve as both the solvent and base for Heck, “copper‐free” Sonogashira reactions, and for homocoupling reactions of terminal alkynes. The ionic liquids with tertiary aliphatic amines are effective solvents for these reactions. Under reflux conditions, eight equivalent basic ionic liquids and Pd(OAc)2 in THF or acetone produced palladium colloids with diameters of (2.6 ± 0.3) or (3.7 ± 0.5) nm, respectively. Preliminary results for Knoevenagel condensations are also reported.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Cytogenetic effects of commercial formulations of deltamethrin and/or isoproturon on human peripheral lymphocytes and mouse bone marrow cells
Authors: Chauhan Lalit K.S. , Kumar Munish , Paul Bhola N. , Goel Sudhir K. , Gupta Shrawan K. 
Published: August 2007

AbstractThe cytogenetic effects of deltamethrin (DEL) and/or isoproturon (ISO) were examined in human lymphocytes and mouse bone marrow cells. Peripheral lymphocytes were exposed to DEL (2.5, 5, 10, or 20 μM), ISO (25, 50, 100, or 200μM), or DEL + ISO (2.5 + 25, 5 + 50, 10 + 100, or 20 + 200 μM) and cytogenic effects were evaluated via chromosomal aberrations (CA) and the cytokinesis‐block micronucleus assay (CBMN). Mice were orally gavaged to single dose of DEL (6.6 mg/kg), ISO (670 mg/kg), or DEL+ISO (6.6 + 670 mg/kg) for 24 hr or to DEL (3.3 mg/kg/day), ISO (330 mg/kg/day), or DEL + ISO (3.3 + 330 mg/kg/day) for 30 days and analyzed for CA. DEL induced a significant frequency of CA at 10 μM whereas ISO (25–100μM) alone, or in combination with DEL, did not show any significant effect. Micronucleus (MN) induction was observed to be concentration‐dependent though significant frequencies were observed at 5 μM DEL, 100 μM ISO, or 5 + 50 μM DEL + ISO. In mice, DEL inhibited the mitotic index (MI) significantly (P < 0.001) at 24 hr while ISO alone, or in combination with DEL, did not cause any statistically significant effect. Following a 24 hr exposure, DEL and ISO alone induced significant (P < 0.01) frequencies of CA, whereas DEL + ISO in combination did not. Furthermore, 30 days exposure of ISO significantly inhibited the MI (P < 0.02 or < 0.01) and induced CA while DEL alone, or in combination with ISO, resulted in no significant effect on CA or the MI. The present findings indicate that the in vitro and in vivo exposure of a commercial formulation of DEL can cause genotoxic effects in mammals. However, the coexposure of DEL and ISO did not show additive effects, but instead demonstrated somewhat reduced genotoxicity. Environ. Mol. Mutagen., 2007. © 2007 Wiley‐Liss, Inc.
Dynamics of soil erosion rates and controlling factors in the Northern Ethiopian Highlands – towards a sediment budget
Authors: Nyssen Jan , Poesen Jean , Moeyersons Jan , Haile Mitiku , Deckers Jozef 
Published: August 2007

AbstractThis paper analyses the factors that control rates and extent of soil erosion processes in the 199 ha May Zegzeg catchment near Hagere Selam in the Tigray Highlands (Northern Ethiopia). This catchment, characterized by high elevations (2100–2650 m a.s.l.) and a subhorizontal structural relief, is typical for the Northern Ethiopian Highlands. Soil loss rates due to various erosion processes, as well as sediment yield rates and rates of sediment deposition within the catchment (essentially induced by recent soil conservation activities), were measured using a range of geomorphological methods. The area‐weighted average rate of soil erosion by water in the catchment, measured over four years (1998–2001), is 14·8 t ha−1 y−1, which accounts for 98% of the change in potential energy of the landscape. Considering these soil loss rates by water, 28% is due to gully erosion. Other geomorphic processes, such as tillage erosion and rock fragment displacement by gravity and livestock trampling, are also important, either within certain land units, or for their impact on agricultural productivity. Estimated mean sediment deposition rate within the catchment equals 9·2 t ha−1 y−1. Calculated sediment yield (5·6 t ha−1 y−1) is similar to sediment yield measured in nearby catchments. Seventy‐four percent of total soil loss by sheet and rill erosion is trapped in exclosures and behind stone bunds. The anthropogenic factor is dominant in controlling present‐day erosion processes in the Northern Ethiopian Highlands. Human activities have led to an overall increase in erosion process intensities, but, through targeted interventions, rural society is now well on the way to control and reverse the degradation processes, as can be demonstrated through the sediment budget. Copyright © 2007 John Wiley & Sons, Ltd.
Investigating parabolic and nebkha dune formation using a cellular automaton modelling approach
Authors: Nield Joanna M. , Baas Andreas C. W. 
Published: August 2007

AbstractVegetation plays an important role in shaping the morphology of aeolian dune landscapes in coastal and semi‐arid environments, where ecogeomorphic interactions are complex and not well quantified. We present a Discrete ECogeomorphic Aeolian Landscape model (DECAL) capable of simulating realistic looking vegetated dune forms, permitting exploration of relationships between ecological and morphological processes at different temporal and spatial scales. The cellular automaton algorithm applies three simple rules that lead to self‐organization of complex dune environments, including nebkhas with distinctive deposition tails that form in association with mesquite‐type shrubs, and hairpin (long‐walled) parabolic dunes with trailing ridges that evolve from blowouts in association with vegetation succession. Changing the conditions of simulations produces differing landscapes that conform qualitatively to observations of real‐world dunes. The model mimics the response of the morphology to changes in sediment supply, vegetation distribution, density and growth characteristics, as well as initial disturbances. The introduction of vegetation into the model links spatial and temporal scales, previously dimensionless in bare‐sand cellular automata. Grid resolutions coarser than the representative size of the modelled vegetation elements yield similar morphologies, but when cell size is reduced to much smaller dimensions, the resultant landscape evolution is dramatically different. The model furthermore demonstrates that the relative response characteristics of the multiple vegetation types and their mutual feedback with geomorphological processes impart a significant influence on landscape equilibria, suggesting that vegetation induces a characteristic length scale in aeolian environments. This simple vegetated dune model illustrates the power and versatility of a cellular automaton approach for exploring the effects of interactions between ecology and geomorphology in complex earth surface systems. Copyright © 2007 John Wiley & Sons, Ltd.
Secotioid Agaricales (Basidiomycetes) from Mongolia
Authors: Dörfelt H. , Gube M. 
Published: August 2007

AbstractA recapitulation of all findings of Mongolian secotioid Agaricales is given. Four species are known: Montagnea arenaria, Montagnea haussknechtii, Endoptychum agaricoides and Gyrophragmium dunalii. Two out of them, M. haussknechtii and E. agaricoides, are reported for the first time in Mongolia. An overview of distribution and systematic relationships of the taxa is given. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Beiträge zur Pilzflora von Mecklenburg‐Vorpommern (Deutschland), 6. Folge
Authors: Kreisel H. 
Published: August 2007

AbstractAus der Region Mecklenburg‐Vorpommern (Nordostdeutschland) werden Funde von 89 Arten Macromyceten und phytoparasitischen Pilzen mitgeteilt. Einige Taxa werden erstmals für die Region nachgewiesen, einige andere nach Jahrzehnten wiedergefunden. Die Verbreitung von neun dieser Arten wird auf Rasterkarten dargestellt. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
E‐cadherin abnormalities resulting from CPG methylation promoter in metastatic and nonmetastatic oral cancer
Authors: de Moraes Renato Vieira , Oliveira Denise Tostes , Landman Gilles , de Carvalho Fabrício , Caballero Otávia , Nonogaki Suely , Nishimoto Inês , Kowalski Luis Paulo 
Published: August 2007

AbstractBackground.This study aims to compare the alterations in the methylation profiles of E‐cadherin in oral cancer, especially in tumors with lowest metatastic potential.Methods.Nine oral verrucous carcinomas (VCs), 20 oral well‐differentiated squamous cell carcinomas without lymph node involvement (SCC‐pN0), and 17 with lymph node involvement (SCC‐pN+) were analyzed using methylation‐specific polymerase chain reaction and immunohistochemical expression of E‐cadherin gene.Results.The immunohistochemical expression of E‐cadherin in VC was significantly higher (p = .016) when compared with SCC‐pN0 and SCC‐pN+ groups. The E‐cadherin gene methylation was not correlated with its abnormal immunohistochemical expression in VC and SCC‐pN0. All tumors of the SCC‐pN+ group with unmethylated E‐cadherin gene showed significant loss of E‐cadherin immunoexpression (p = .044).Conclusions.The E‐cadherin gene methylation presence in tumors with lowest invasive and metastatic potential, such as VC, suggests the early involvement of this epigenetic event in the multistep progression of the oral carcinogenesis. © 2007 Wiley Periodicals, Inc. Head Neck, 2008
Space–time rainfall variability in the Paute basin, Ecuadorian Andes
Authors: Celleri Rolando , Willems Patrick , Buytaert Wouter , Feyen Jan 
Published: August 2007

AbstractDespite the importance of mountain ranges as water providers, knowledge of their climate variability is still limited, mostly due to a combination of data scarcity and heterogeneous orography. The tropical Andes share many of the main features of mountain ranges in general, and are subject to several climatic influences that have an effect on rainfall variability. Although studies have addressed the large‐scale variation, the basin scale has received little attention. Thus, the purpose of this study was to obtain a better understanding of rainfall variability in the tropical Andes at the basin scal, utilizing the Paute River basin of southern Ecuador as a case study. Analysis of 23 rainfall stations revealed a high spatial variability in terms of: (i) large variations of mean annual precipitation in the range 660–3400 mm; (ii) the presence of a non‐monotonic relation between annual precipitation and elevation; and (iii) the existence of four, sometimes contrasting, rainfall regimes. Data from seven stations for the period 1964–1998 was used to study seasonality and trends in annual, seasonal and monthly precipitation. Seasonality is less pronounced at higher elevations, confirming that in the páramo region, the main water source for Andean basins, rainfall is well distributed year round. Additionally, during the period of record, no station has experienced extreme concentrations of annual rainfall during the wet season, which supports the concept of mountains as reliable water providers. Although no regional or basin‐wide trends are found for annual precipitation, positive (negative) trends during the wet (dry) season found at four stations raises the likelihood of both water shortages and the risk of precipitation‐triggered disasters. The study demonstrates how variable the precipitation patterns of the Andean mountain range are, and illustrates the need for improved monitoring. Copyright © 2007 John Wiley & Sons, Ltd.
Stream network modelling using lidar and photogrammetric digital elevation models: a comparison and field verification
Authors: Murphy Paul N. C. , Ogilvie Jae , Meng Fan‐Rui , Arp Paul 
Published: August 2007

AbstractA conventional, photogrammetrically derived digital elevation model (DEM; 10 m resolution) and a light detection and ranging (lidar)‐derived DEM (1 m resolution) were used to model the stream network of a 193 ha watershed in the Swan Hills of Alberta, Canada. Stream networks, modelled using both hydrologically corrected and uncorrected versions of the DEMs and derived from aerial photographs, were compared. The actual network, mapped in the field, was used as verification. The lidar DEM‐derived network was the most accurate representation of the field‐mapped network, being more accurate even than the photo‐derived network. This was likely due to the greater initial point density, accuracy and resolution of the lidar DEM compared with the conventional DEM. Lidar DEMs have great potential for application in land‐use planning and management and hydrologic modelling. The network derived from the hydrologically corrected conventional DEM was more accurate than that derived from the uncorrected one, but this was not the case with the lidar DEM. Copyright © 2007 John Wiley & Sons, Ltd.
Effects of postnatal ethanol exposure on neurotrophic factors and signal transduction pathways in rat brain
Authors: Fattori Vittorio , Abe Shin‐ichi , Kobayashi Kumiko , Costa Lucio G. , Tsuji Ryozo 
Published: August 2007

AbstractExposure to ethanol during development induces severe brain damage, resulting in a number of CNS dysfunctions including microencephaly and mental retardation. Potential targets of ethanol‐induced neurotoxicity include neurotrophic factors and their signal transduction pathways. In the present study, rat pups were given ethanol at the dose of 5 g kg−1 via gavage from postnatal day (PND) 5 to 8, and mRNA expression of nerve growth‐factor (NGF), brain‐derived neurotrophic factor (BDNF), and neurotrophic factor‐3 (NT‐3) in the cerebral cortex was examined, with attention to signal transduction, on PND 8. The mRNA level of BDNF was decreased by ethanol while those of NGF or NT‐3 were not changed. Brain weights were decreased and the levels of phospho‐MAPK, phospho‐p70S6K and phospho Akt were decreased while phosphor‐PKCζ and phospho‐CREB remained unchanged. These results suggest that BDNF and its related signal pathways involving Akt, MAPK and p70S6K are potential targets of ethanol‐induced developmental neurotoxicity. Copyright © 2007 John Wiley & Sons, Ltd.