bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing androgen receptor prioritization using high-throughput assay-based activity models
Authors: Bever Ronnie Joe , Edwards Stephen W. , Antonijevic Todor , Nelms Mark D. , Ring Caroline , Harris Danni , Lynn Scott G. , Williams David , Chappell Grace , Boyles Rebecca , Borghoff Susan , Markey Kristan J. 
Published: March 2024

Introduction: Computational models using data from high-throughput screening assays have promise for prioritizing and screening chemicals for testing under the U.S. Environmental Protection Agency’s Endocrine Disruptor Screening Program (EDSP). The purpose of this work was to demonstrate a data processing method for the determination of optimal minimal assay batteries from a larger comprehensive model, to provide a uniform method of evaluating the performance of future minimal assay batteries compared with the androgen receptor (AR) pathway model, and to incorporate chemical cluster analysis into this evaluation. Although several of the assays in the AR pathway model are no longer available through the original vendor, this approach could be used for future evaluations of minimal assay models for prioritization and screening.Methods: We compared two previously published models and found that an expanded 14-assay model had higher sensitivity for antagonists, whereas the original 11-assay model had slightly higher sensitivity for agonists. We then investigated subsets of assays in the original AR pathway model to optimize overall testing strategies that minimize cost while maintaining sensitivity across a broad chemical space.Results and Discussion: Evaluation of the critical assays across subset models derived from the 14-assay model identified three critical assays for predicting antagonism and two critical assays for predicting agonism. A minimum of nine assays is required for predicting agonism and antagonism with high sensitivity (95%). However, testing workflows guided by chemical structure–based clusters can reduce the average number of assays needed per chemical by basing the assays selected for testing on the likelihood of a chemical being an AR agonist, according to its structure. Our results show that a multi-stage testing workflow can provide 95% sensitivity while requiring only 48% of the resources required for running all assays from the original full models. The resources can be reduced further by incorporating in silico activity predictions.Conclusion: This work illustrates a data-driven approach that incorporates chemical clustering and simultaneous consideration of antagonism and agonism mechanisms to more efficiently screen chemicals. This case study provides a proof of concept for prioritization and screening strategies that can be utilized in future analyses to minimize the overall number of assays needed for predicting AR activity, which will maximize the number of chemicals that can be tested and allow data-driven prioritization of chemicals for further screening under the EDSP.
Effect of diets supplemented with coated plant essential oil on the growth performance, immunity, antioxidant activity, and fecal microbiota of weaned piglets
Authors: Niu Yu , Chen Yiying , Liu Jinsong , Liu Yulan , Xiao Shiping , Yang Caimei , Yang Ting , Huan Weiwei 
Published: March 2024

IntroductionThis trial was conducted to compare the effect of diets supplemented with plant essential oil (PEO) and coated plant essential oil (CEO) on growth performance, immunity, antioxidant activity, and fecal microbiota of weaned piglets.MethodsA total of 360 21-day-old weaned piglets were randomly allocated into three groups, namely, CON, PEO, and CEO (basal diets supplemented with 0, 500 mg/kg PEO, and 500 mg/kg CEO, respectively) for a 4-week feeding trial.Results and discussionThe results showed that dietary supplementation with CEO improved the average final weight and average daily gain, decreased the diarrhea rate, increased antioxidant enzyme activities, enhanced immunoglobulin concentrations, and decreased concentrations of pro-inflammatory cytokines in the serum of weaned piglets (p &lt; 0.05). In addition, CEO addition increased the fecal concentrations of propionic acid and isovaleric acid of piglets (p &lt; 0.05). Spearman correlation analysis showed that fecal microorganisms at the genus level were closely correlated with the volatile fatty acid concentrations. The present study indicated that PEO and CEO could improve growth performance, enhance immunity, and increase antioxidant capacity by modulating the microbial flora in weaned piglets. Moreover, CEO addition seemed to offer more positive results than of PEO addition.
Genome-Wide Analysis of VILLIN Gene Family Associated with Stress Responses in Cotton (Gossypium spp.)
Authors: Deep Akash , Pandey Dhananjay K. 
Published: March 2024

The VILLIN (VLN) protein plays a crucial role in regulating the actin cytoskeleton, which is involved in numerous developmental processes, and is crucial for plant responses to both biotic and abiotic factors. Although various plants have been studied to understand the VLN gene family and its potential functions, there has been limited exploration of VLN genes in Gossypium and fiber crops. In the present study, we characterized 94 VLNs from Gossypium species and 101 VLNs from related higher plants such as Oryza sativa and Zea mays and some fungal, algal, and animal species. By combining these VLN sequences with other Gossypium spp., we classified the VLN gene family into three distinct groups, based on their phylogenetic relationships. A more in-depth examination of Gossypium hirsutum VLNs revealed that 14 GhVLNs were distributed across 12 of the 26 chromosomes. These genes exhibit specific structures and protein motifs corresponding to their respective groups. GhVLN promoters are enriched with cis-elements related to abiotic stress responses, hormonal signals, and developmental processes. Notably, a significant number of cis-elements were associated with the light responses. Additionally, our analysis of gene-expression patterns indicated that most GhVLNs were expressed in various tissues, with certain members exhibiting particularly high expression levels in sepals, stems, and tori, as well as in stress responses. The present study potentially provides fundamental insights into the VLN gene family and could serve as a valuable reference for further elucidating the diverse functions of VLN genes in cotton.
Le γλεῦκος dans tous ses états. Le moût, le « vin doux », le vin nouveau et la maîtrise du processus fermentaire dans le monde égéen de l’époque classique à l’époque byzantine
Authors: Boulay Thibaut 
Published: March 2024

This article explores the winemaking practices of the Greeks in the Aegean world, from classical times to late antiquity, reading the ancient sources in the light of the latest progress in oenology. Following the process of wine-making from the harvest and its crushing to the moment of the opening of the amphoras and the consumption of wine, it shows that the winemakers used a variety of efficient techniques to supervise fermentation. Resulting from overripe harvests, the must, aged in an oxidative atmosphere, could, if necessary, receive plant or mineral inputs in different forms to correct its sugar content and acidity. These additions also had an antibacterial and antifungal action contributing, like tanning and salting, to the stability of the must. Thermoregulation permitted a long term consumption of unfermented must, especially within the context of
γλυκισμοί.
EDUCAÇÃO FINANCEIRA E A PRESENÇA DOS PILARES DO PENSAMENTO COMPUTACIONAL EM ATIVIDADES PLUGADAS: UMA REVISÃO SISTEMÁTICA DE LITERATURA
Authors: Cenci Danuza , Kist Milton 
Published: March 2024

Neste artigo apresentamos uma revisão sistemática de teses e dissertações contidas no banco de dados da Capes visando encontrar e avaliar atividades realizadas em sala de aula com estudantes da Educação Básica, explorando conceitos de Educação Financeira que utilizaram ferramentas digitais para auxiliar no processo de ensino e de aprendizagem. A avaliação buscou identificar a presença dos pilares do Pensamento Computacional nas atividades e quais foram desenvolvidos pelos estudantes durante a resolução. A pesquisa realizada em setembro de 2022, no banco de dados da Capes identificou trinta e três trabalhos que passaram pelo protocolo inicial da revisão sistemática resultando em seis trabalhos para leitura na íntegra. Desses seis trabalhos, quatro foram selecionados para análise por conterem o objeto de interesse dessa pesquisa e neles constatou-se que os pilares, os quais se baseia o Pensamento Computacional: Decomposição, Reconhecimento de Padrões, Abstração e Algoritmo, estiveram presentes e contribuíram para o fortalecimento e compreensão de conceitos de Educação Financeira.
Palavras-chave: Pensamento Computacional. Educação Financeira. Educação Básica. Tecnologias Digitais.
Dual integration design of approximate random weight generator and computation-in-memory for event-based neuromorphic computing
Authors: Misawa Naoko , Koshino Shunsuke , Liu Ruhui , Matsui Chihiro , Takeuchi Ken 
Published: March 2024

Abstract
This paper comprehensively analyses dual integration of approximate random weight generator (ARWG) and computation-in-memory for event-based neuromorphic computing. ARWG can generate approximate random weights and perform multiply-accumulate (MAC) operation for reservoir computing (RC) and random weight spiking neural network (SNN). Because of using device variation to generate random weights, ARWG does not require any random number generators (RNGs). Because RC and random weight SNN allow approximate randomness, ARWG only needs to generate approximate random weights, which does not require error-correcting code to correct weights to make the randomness accurate. Moreover, ARWG has a read port for MAC operation. In this paper, the randomness of random weights generated by the proposed ARWG is evaluated by Hamming distance and Hamming weight. As a result, this paper reveals that the randomness required for ARWG is much lower than that for physically unclonable functions and RNGs, and thus the proposed ARWG achieves high recognition accuracy.
Investigation of vacancy-type defects in diamond-like carbon films using slow positron beam
Authors: Kanda Kazuhiro , Mishima Tomohiro , Akasaka Hiroki , Hori Fuminobu , Yabuuchi Atsushi , Kinomura Atsushi 
Published: March 2024

Abstract
Positron annihilation spectroscopy was used to investigate vacancy-type defects in diamond-like carbon (DLC) films. From Doppler broadening measurements of the γ-rays produced by annihilation and positron annihilation lifetime (PAL) using a slow positron beam on DLC films deposited by various deposition methods and conditions, it was found that there is a good correlation between the S parameter obtained by Doppler broadening and PAL. The result of PAL correlates well with film density and hardness, indicating that PAL measurements can be used as an indicator of these film properties. The hydrogen content in the DLC film was roughly proportional to the PAL. However, there were also cases in which PAL differed greatly even with almost the same hydrogen content, and the sp
2/(sp
2+sp
3) ratio of carbon in DLC films has no direct relationship with PAL.
A Systematic Review of Research to Determine Toxicity of Involuntary Tobacco Smoking as Compared to First Hand Smoking and if Chronic Involuntary Tobacco Smoking during Childhood Causes Skeletal Diseases Later in Life
Authors: Bobzien Michael J 
Published: March 2024

A child will breath up to 3 times the volume per body weight compared to an adult. A child’s organs and immune system are not fully developed to offer protection from airborne and residual toxins compared to an adult. A child is unable to control their environment or escape their home environment, an adult can change jobs or leave a toxic environment. Thus, children are the most susceptible to the effects of toxins in their environment. Tobacco Smoke exposure is the greatest toxic exposure risk a child faces in a home environment. Tobacco Smoke exposure starts in the womb when the embryo embeds in the mother’s uterus and connects to their mother’s blood flow. Tobacco smoke contains many osteotoxic, nephrotoxic, cytotoxic, and genotoxic chemicals that significantly alter genetic material in the developing fetus and child, which has long-term health effects leading to poor bone health and skeletal diseases later in life. Three of the many thousands of toxins in tobacco smoke which are most osteotoxic, nephrotoxic, cytotoxic, and genotoxic are lead, cadmium, and polycyclic aromatic hydrocarbons.
Pengabdian Kepada Masyarakat Optimasi Penggunaan Email Belajar.Id Sebagai Sarana Cloud Education di SMP Negeri 1 Dringu
Authors: Fajri Fathorazi Nur , Supriadi Yulius , Dani Ahmad , Zulkarnain Moh Agung , Kafila Fabio 
Published: March 2024

pengabdian kepada masyarakat yang bertujuan untuk mengoptimalkan penggunaan email Belajar.id sebagai sarana pendidikan berbasis awan di SMP Negeri 1 Dringu. Hal ini disebabkan adanya kendala dalam penerapan teknologi pendidikan di sekolah tersebut, yang menghambat proses pembelajaran. Terutama pada rendahnya pemanfaatan email Belajar.id oleh guru dan siswa, sehingga memengaruhi kualitas pendidikan di SMP Negeri 1 Dringu. Bentuk pengabdian yang dilakukan mencakup pelatihan dan pendampingan kepada guru dan siswa dalam mengoptimalkan penggunaan email Belajar.id. Solusi yang diterapkan melibatkan penyediaan panduan praktis, pelatihan interaktif penggunaan email Belajar.id yang efektif. Hasil pengabdian menunjukkan peningkatan signifikan dalam pemanfaatan email Belajar.id sebagai sarana cloud education di SMP Negeri 1 Dringu. Guru dan siswa lebih terampil dalam memanfaatkan platform ini untuk mengakses sumber belajar, tugas, dan berkomunikasi dalam konteks pendidikan. Hal ini berkontribusi pada peningkatan kualitas pembelajaran dan efisiensi dalam administrasi sekolah
Differential effects on soil water repellency of Eucalyptus and Pinus plantations replacing natural pastures
Authors: González-Sosa Maximiliano , González-Barrios Pablo , Bentancur Oscar José , Pérez-Bidegain Mario 
Published: March 2024

ABSTRACT

Land-use changes from native pastures to forest plantations in humid temperate areas have raised concerns about their potential impact on the environment. This study aimed to assess the effects of such changes on soil water properties, focusing on the impact of the forest species planted and their relationship with changes in soil C content. Specifically, we aimed to identify the development of surficial soil hydrophobicity and changes in soil water holding capacity. A long-term forest experiment with variable planting densities (816, 1111, and 2066 trees ha
-1
) of Eucalyptus grandis Hill ex Maiden and Pinus taeda L. was established in 2004 on native pasture vegetation. Undisturbed soil samples (0.00-0.03 m soil layer) were extracted from the experiment and surrounding pastures and soil water repellency was determined by the water drop penetration time (WDPT) method at three soil matric potential levels (SMP). Bootstrapping was used to test if the sample size was sufficient to obtain robust results. Replacing native pastures with forest plantations significantly increased surficial soil hydrophobicity, which was more pronounced under Eucalyptus grandis than under Pinus taeda. Soil water repellency increased with decreasing SMP, particularly in land-uses that generated higher initial hydrophobicity. Additionally, the soils under forest cover had less water retention capacity than those under pastures at each SMP, with larger differences when the soil was dried to more negative SMP. More research is necessary to determine if soil alterations from converting native pastures to forest plantations in temperate climates will lead to a significant decrease in soil water holding capacity and an increase in hydrophobicity at deeper depths.
Travelling to the Secular or Journeying Inside The Self: Jurje Zaidane’s Gaze on European Modernity (Rihla Ila Oroba 1912, A Travel To Europe)
Authors: Tritha Abdelaziz 
Published: March 2024

Starting from his confrontational allegiance and parochial thesis, namely in his Essays and Lectures of William Robertson Smith(1912), William Robertson Smith discredits Arab travellers for their zealous keenness to discover Western cultural intricacies. He has examined the cultural practices and social kinships of Semite people and studied their theologies. William Robertson Smith went as far as to assume that “The Arabian traveller is quite different from ourselves. The labour of moving from place to place is a mere nuisance to him, he has no enjoyment in the effort, and grumbles at hunger or fatigue with all his might” (Smith, 1912, p: 498). My particular interest is in Jurje Zaidane’s Rihla Ila Oroba (1912) as a culturally inspired travel account to France and England. It is not only a voyage to discern the intricacies of the Western civilizational repositories but an interesting endeavour to demonstrate the long-standing tradition of Arabs’ presence in British and French cultural repertoire. His voyage shows the extent to which Arabs were inspired by Western modern logos. Jurje Zaidane minutely lingers on infinitesimal details of each country. I argue that this travel is a parallel occidentalist discourse that tries to create a counter-discursive narrative. Jurje Zaidane, from the perspective of a well-versed essayist, novelist and erudite traveller, cross-examines French and English cultural contexts. Ranging from the narration of public spaces to comments on French and English women, the journey towards the Other is vicariously shifted to Self-inquiry and discovery. Broached from a postcolonial micro-historicist approach, this paper aims at stultifying both the orientalist discourse and the occidentalist premise predicated on Hassan Hanafi’s allegiance to Occidentalism. This article concludes that Zaidane’s travel displays heterogeneous discourses that do not re-install sharp divisive between the East and the West.
Job Satisfaction and Organizational Citizenship Behavior (OCB) in Nurses
Authors: Dulahu Wirda Y , Mun'Im Abdul , Hiola Dewi Suryaningsih , Hunawa Rachmawaty D 
Published: March 2024

The quality of service in hospitals can be improved if individuals, in this case nurses, have Organizational Citizenship Behavior (OCB). OCB is a form of behavior that is a choice of individual initiative and is not related to the organization's formal reward system but in aggregate increases organizational effectiveness. Objective: This research aims to determine the relationship between the level of job satisfaction and the OCB of nurses in Dr. RSUD. M.M Dunda Limboto inpatient ward. Method: Quantitative research method, Analytical Survey research design with a Cross-Sectional approach. The population in this study was 215 nurses and the sample used was 121 inpatient nurses, with a sampling technique using purposive sampling. This research uses the Spearman Rank Test. Results: the research results obtained a correlation coefficient of r= 0.342 (p-value = 0.000 or < 0.005), meaning that there is a relationship between job satisfaction and the level of OCB of nurses in the inpatient room at Dr. M.M Dunda Limboto. Conclusions: It is expected that hospital institutions can pay attention to the factors that influence job satisfaction in nurses so that they have a positive impact on the level of Organizational Citizenship Behavior in nurses.
Prácticas de retroalimentación y su alineamiento con el nuevo Marco para la Buena Enseñanza 2021: un estudio de caso
Authors: Mancilla Salinas Milytza , Álvarez Mancilla Bárbara , Díaz Rosas Joselyn 
Published: March 2024

Uno de los recientes cambios en educación corresponde a la implementación de los nuevos Estándares de la Profesión Docente: Marco para la Buena Enseñanza, documento que tiene foco específico en la retroalimentación. La presente investigación busca identificar las prácticas de retroalimentación de los docentes de un Liceo Técnico Profesional de Puerto Montt y su alineamiento con las nuevas demandas del dominio C de los Estándares de la Profesión Docente MBE 2021. A través de un diseño cualitativo, se realizaron entrevistas estructuradas; luego, la transcripción se llevó a cabo mediante un análisis temático que permitió identificar cuatro temas principales, cada uno compuesto por dos códigos, los cuales implican comprensiones diversas y profundas sobre el tema estudiado. A través de los resultados se busca aportar con información actualizada, pertinente y contextualizada acerca de las prácticas docentes y la mejora de los aprendizajes de las estudiantes. A su vez, se pretende aportar a la teoría investigativa con una reconceptualización de la retroalimentación en evaluación.
Long-term Evolution of Relativistic Unmagnetized Collisionless Shocks
Authors: Grošelj Daniel , Sironi Lorenzo , Spitkovsky Anatoly 
Published: March 2024

Abstract
We study a relativistic collisionless electron–positron shock propagating into an unmagnetized ambient medium using 2D particle-in-cell simulations of unprecedented duration and size. The shock generates intermittent magnetic structures of increasingly larger size as the simulation progresses. Toward the end of our simulation, at around 26,000 plasma times, the magnetic coherence scale approaches λ ∼ 100 plasma skin depths, both ahead and behind the shock front. We anticipate a continued growth of λ beyond the time span of our simulation, as long as the shock accelerates particles to increasingly higher energies. The post-shock field is concentrated in localized patches, which maintain a local magnetic energy fraction ε

B
∼ 0.1. Particles randomly sampling the downstream fields spend most of their time in low field regions (ε

B
≪ 0.1) but emit a large fraction of the synchrotron power in the localized patches with strong fields (ε

B
∼ 0.1). Our results have important implications for models of gamma-ray burst afterglows.
Fermi Resonance and the Quantum Mechanical Basis of Global Warming
Authors: Wordsworth R. , Seeley J. T. , Shine K. P. 
Published: March 2024

Abstract
Although the scientific principles of anthropogenic climate change are well-established, existing calculations of the warming effect of carbon dioxide rely on spectral absorption databases, which obscures the physical foundations of the climate problem. Here, we show how CO2 radiative forcing can be expressed via a first-principles description of the molecule’s key vibrational-rotational transitions. Our analysis elucidates the dependence of carbon dioxide’s effectiveness as a greenhouse gas on the Fermi resonance between the symmetric stretch mode ν
1 and bending mode ν
2. It is remarkable that an apparently accidental quantum resonance in an otherwise ordinary three-atom molecule has had such a large impact on our planet’s climate over geologic time, and will also help determine its future warming due to human activity. In addition to providing a simple explanation of CO2 radiative forcing on Earth, our results may have implications for understanding radiation and climate on other planets.