bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical inhibition of the integrated stress response impairs the ubiquitin-proteasome system
Authors: Xu Shanshan , Gierisch Maria E. , Barchi Enrica , Poser Ina , Alberti Simon , Salomons Florian A. , Dantuma Nico P. 
Published: March 2024

AbstractThe Integrated Stress Response Inhibitor (ISRIB) is an experimental compound that has been used to explore the potential beneficial effects of reducing the activation of the integrated stress response (ISR). As the ISR is a protective response, there is, however, a risk that its inhibition may compromise the cell’s ability to restore protein homeostasis. Here, we show that ISRIB treatment impairs degradation of proteins by the ubiquitin-proteasome system (UPS) during proteotoxic stress in the cytosolic, but not nuclear, compartment. Degradation of proteins intercepted by ribosome quality control (RQC) was particularly affected as accumulation of a UPS reporter substrate for ribosome quality control (RQC) was comparable to the level observed after proteasome inhibition. Consistent with impaired RQC, ISRIB treatment caused an accumulation of polyubiquitylated and detergent insoluble defective ribosome products (DRiPs) in the presence of puromycin. As depletion of the RQC ubiquitin ligase listerin partially restored ubiquitin-dependent proteasomal degradation, these data suggest that the persistent protein translation during proteotoxic stress in ISRIB-treated cells increases the pool of newly synthesized proteins targeted by RQC, which aggravates UPS dysfunction by overloading the cytosolic UPS.
Factors influencing online health information credibility: a meta-analysis
Authors: Zhao Yuehua , Zhang Linyi , Zeng Chenxi , Chen Yidan , Lu Wenrui , Song Ningyuan 
Published: March 2024

PurposeThis study aims to address the growing importance of online health information (OHI) and the associated uncertainty. Although previous research has explored factors influencing the credibility of OHI, results have been inconsistent. Therefore, this study aims to identify the essential factors that influence the perceived credibility of OHI by conducting a meta-analysis of articles published from 2010 to 2022. The study also aims to examine the moderating effects of demographic characteristics, study design and the platforms where health information is located.Design/methodology/approachBased on the Prominence-Interpretation Theory (PIT), a meta-analysis of 25 empirical studies was conducted to explore 12 factors related to information content and source, social interaction, individual and media affordance. Moderators such as age, education level, gender of participants, sample size, platforms and research design were also examined.FindingsResults suggest that all factors, except social support, have significant effects on the credibility of OHI. Among them, argument quality had the strongest correlation with credibility and individual factors were also found to be relevant. Moderating effects indicate that social support was significantly moderated by age and education level. Different sample sizes may lead to variations in the role of social endorsement, while personal involvement was moderated by sample size, platform and study design.Originality/valueThis study enriches the application of PIT in the health domain and provides guidance for scholars to expand the scope of research on factors influencing OHI credibility.
Financialization and labor discipline in contemporary capitalism
Authors: Prata Feres Lucas , Wilhans Antonio Palludeto Alex , Oliveira Rodrigues Dias Hugo Miguel 
Published: March 2024

PurposeDrawing upon a political economy approach, this article aims to analyze the transformations in the labor market within the context of contemporary capitalism, focusing on the phenomenon of financialization.Design/methodology/approachFinancialization is defined as a distinct wealth pattern marked by a growing proportion of financial assets in capitalist wealth. Within financial markets, corporate performance is continuously assessed, in a process that disciplines management to achieve expected financial results, with consequences throughout corporate management.FindingsWe find that this phenomenon has implications for labor management, resulting in the intensification of labor processes and the adoption of insecure forms of employment, leading to the fractalization of work. These two mechanisms, added to the indebtedness of workers, constitute three elements for disciplining labor in contemporary capitalism.Originality/valueWe argue that these forms of discipline constitute a subsumption of labor to finance, resulting in an increase in labor exploitation. This formulation of the relationship between financialization and changes in the realm of labor also contributes to understanding the unrealizing potential of social free time in contemporary capitalism.
Networks, ownership and productivity does firm age play a moderating role?
Authors: Aiello Francesco , Cardamone Paola , Mannarino Lidia , Pupo Valeria 
Published: March 2024

Purpose The purpose of this study is to investigate whether and how inter-firm cooperation and firm age moderate the relationship between family ownership and productivity.Design/methodology/approachWe first estimate the total factor productivity (TFP) of a large sample of Italian firms observed over the period 2010–2018 and then apply a Poisson random effects model.FindingsTFP is, on average, higher for non-family firms (non-FFs) than for FF. Furthermore, inter-organizational cooperation and firm age mitigate the negative effect of family ownership. In detail, it is found that belonging to a network acts as a moderator in different ways according to firm age. Indeed, young FFs underperform non-FF peers, although the TFP gap decreases with age. In contrast, the benefits of a formal network are high for older FFs, suggesting that an age-related learning process is at work.Practical implicationsThe study provides evidence that FFs can outperform non-FFs when they move away from Socio-Emotional Wealth-centered reference points and exploit knowledge flows arising from high levels of social capital. In the case of mature FFs, networking is a driver of TFP, allowing them to acquire external resources. Since FFs often do not have sufficient in-house knowledge and resources, they must be aware of the value of business cooperation. While preserving the familiar identity of small companies, networks grant FFs the competitive and scale advantages of being large.Originality/valueDespite the wide but ambiguous body of research on the performance gap between FFs and non-FFs, little is known about the role of FFs’ heterogeneity. This study has proven successful in detecting age as a factor in heterogeneity, specifically to explain the network effect on the link between ownership and TFP. Based on a representative sample, the study provides a solid framework for FFs, policymakers and academic research on family-owned companies.
Unpacking product design awards: a qualitative inquiry into consumer perceptions and responses
Authors: Idemen Elif , Elmadag A. Banu 
Published: March 2024

Purpose
This paper aims to explore consumer perceptions of product design awards (PDAs) and their impact on consumer product evaluation and attitude formation about the award-winning product, the award-winning organization and the award-granting organization.

Design/methodology/approach
Based on the grounded theory approach, an exploratory qualitative study is conducted, using 16 semi-structured in-depth interviews with Turkish consumers through discussions on real-world examples.

Findings
Results show that consumers develop emotional responses to PDAs (e.g. interest, curiosity and confusion), hypothesize reasons for products receiving awards and cite rewards as confirmation of their existing judgments about products. PDAs are perceived as extrinsic cues signaling quality and price, and their impact is increased when consumers feel that the award is based on functional feature superiority. Consumer responses to PDAs are also influenced by the perceived expertise of the award-granting organization and beliefs about the award-granting process. Finally, PDAs can lead to positive brand-perception outcomes, influencing consumer perceptions of the product company as resourceful, competent and prominent.

Practical implications
This study shows that it is critical for companies to inform consumers about the specific features that resulted in a given product receiving a design award, as well as to provide information about the PDA itself.

Originality/value
To the best of the authors’ knowledge, this study is the first attempt to explore consumer perceptions of and reactions to PDAs, with significant implications for both the marketing managers of PDA-winning products and award-granting organizations.
Climate change and the European banking sector: the effect of green technology adaptation and human capital
Authors: Afzal Ayesha , Hasnaoui Jamila Abaidi , Firdousi Saba , Noor Ramsha 
Published: March 2024

Purpose
Climate change poses effect on banking sector’s risks and profitability through adaptation of green technology. This study aims to incorporates green technology adaptation in three sectors: green banking, green entrepreneurial innovation (EI) and green human resource (HR), in a model of bank’s performance. And determines the impact of climate change on bank risk and profitability.

Design/methodology/approach
An assessment of profitability and risk profile of commercial banks is done for 27 European countries for 2013–2022, employing a two-step difference system-generalized method of moments estimation technique with a moderate effect of climate change by including interaction between climate change and green technology adaptation.

Findings
The results indicate that green banking increases profitability, reduces credit risk and increases liquidity risk. The results also show that green human resource increases profitability and becomes a source of credit and liquidity risks for the banks. Green EI increases credit risk and liquidity risk, while the effects of green EI on profitability vary with the use of two proxies: Green patents increase profitability and environment, social and corporate governance (ESG) scores decrease profitability.

Practical implications
Supportive government initiatives, including subsidies and tax rebates to green borrowers, may take the burden of green transition off the banking sector.

Originality/value
This paper observes the impact of green technology adaptation in three sectors: banks, EI and HR, moderated by climate change, adding substantially to the existing literature in conceptual framework and methodology.
Tackling Climate Change with End‐of‐Life Circular Fashion Practices—Remade in Italy with Amore
Authors: Colucci Mariachiara , Vecchi Alessandra 
Published: March 2024

AbstractThe fashion industry makes a sizeable contribution to climate change. Research on grand challenges has now gained momentum in the management literature, given the vast array of grand challenges that are now globally affecting industries, societies and governments, such as the COVID‐19 pandemic, the war in Ukraine and global warming. By coupling paradox theory with the literature on circular economy, this paper investigates the end‐of‐life circular practices implemented by ‘born‐circular’ Italian fashion companies. The paper focuses on upcycling and remanufacturing, which have been neglected in the literature and whose widespread implementation has been deemed suitable to tackle climate change. The analysis of several in‐depth interviews with companies and industry experts results in the development of a process model. The model provides granular insights into the environmental value created by the implementation of end‐of‐life circular practices by fashion firms in their quest to tackle climate change. The study both suggests that paradox theory is likely to have broader applicability to reconcile a wide set of managerial and societal issues and also supports the argument that overcoming an intrinsic paradox could lead to a strategic pivoting within an industry that might yield a paradigm shift.
Holistically bridging the gap between education and healthcare: A case study model of assessment
Authors: Hannant Penelope 
Published: March 2024

AbstractIn today's special educational needs and disability system, children spend an incomprehensible amount of time on waiting lists to see specialists, and teachers and parents spend an inordinate amount of time trying to target support when a child's needs are unidentified and unclear. This case study looks at the current pathway to support for children with neurodiversities in UK mainstream schools, considering in detail the role of the professionals around the child, in particular the SENCo. In this case study, three children are discussed; in these cases, an additional layer of assessment was included in the referral system, using Frith's causal modelling. This resulted in a more accurate and timely diagnosis of neurodiversities, whether singular or co‐occurring, in each case. The additional assessment level was undertaken by a developmental psychologist (DP) who acted as a catalyst for the assessment process and an advisor to target intervention. Following a holistic assessment by the DP, one child was diagnosed with autism on the NHS within three months of the assessment, one child was diagnosed with attention deficit/hyperactivity disorder on the NHS within six months of the assessment, and one child had a dual diagnosis of dyslexia and dyspraxia. Moreover, importantly, only one child's outcomes matched the SENCo's initial diagnostic hypothesis. Two possible, and probably controversial, assessment models are proposed, that take the guesswork out of the referral process for the SENCo, saving time and money across all sectors, while considering a child's needs holistically and wholly.
Travel distance and outcomes after surgical aortic valve among veterans
Authors: Beaulieu‐Jones Brendin R. , Siegel Noah , Collado Loreski , Mull Hillary J. , Quin Jacquelyn A. 
Published: March 2024

AbstractObjectiveTo investigate the association between travel distance and postoperative length of stay (LOS) and discharge disposition among veterans undergoing surgical aortic valve replacement (SAVR).Data Sources/Study SettingWe performed a retrospective cohort study of patients undergoing SAVR, with or without coronary artery bypass grafting (CABG) at VA Boston Healthcare (January 1, 2005–December 31, 2015).Study DesignPostoperative LOS and discharge disposition were compared for SAVR patients based on travel distance to the facility: <100 miles or ≥100 miles. Multivariable regression was performed to ascertain factors associated with LOS and home discharge.Data Collection/Extraction MethodsData were collected via chart review. All patients undergoing SAVR at our institution who primarily resided within the defined region were included.Principal FindingsOf 597 patients studied, 327 patients underwent isolated SAVR; 270 patients underwent SAVR/CABG. Overall median (IQR) distance between the patient's residence and the hospital was 49.95 miles (27.41–129.94 miles); 190 patients (32%) resided further than 100 miles away. There were no differences in the proportion of patients with diabetes, hypertension, chronic obstructive pulmonary disease (COPD), cerebrovascular disease, atrial fibrillation, or prior myocardial infarction between groups. Overall LOS (IQR) was 9 (7–13) days and did not differ between groups (p = 0.18). The proportion of patients discharged home was higher among patients who resided more than 100 miles from the hospital (71% vs. 58%, p = 0.01). On multivariable analysis, residing further than 100 miles from the hospital was independently associated with home discharge (OR = 1.64, 95% CI: 1.09–2.48). Travel distance was not associated with LOS.ConclusionsBased on our institutional experience, potential concerns of longer hospital stay or discharge to other inpatient facilities for geographically distanced patients undergoing SAVR do not appear supported. Continued examination of the drivers underlying the marked shift of veterans to the private sector appears warranted.
Identification of lymph node adulteration in minced pork by comprehensive metabolomics and lipidomics approach based on UPLC/LTQ‐Orbitrap MS
Authors: Wang Wei , Jiang Feng , Wu Wan‐Qin , Zhu Xiao‐Ling , Wang Hui‐xia , Zhang Li , Fan Zhi‐yong 
Published: March 2024

AbstractThe deliberate pork adulteration with lymph nodes is a common adulteration phenomenon, and it poses a serious threat to public health and food safety. An untargeted metabolomics and lipidomics approach based on ultrahigh performance liquid chromatography coupled with linear ion trap quadrupole‐Orbitrap high resolution mass spectrometry (MS) was used to distinguish lymph nodes from minced pork. The principal component analysis and orthogonal projection to latent structures discriminant analysis models were established with the good of fitness and predictivity. The results showed that there were significant differences in metabolites and lipids between lymph nodes and pork. A total of 16 significantly differentiated metabolites were identified, of which 1‐palmitoylglycerophosphocholine, 12,13‐dihydroxy‐9‐octadecenoic acid, and prostaglandin E2 (PGE2) were positively correlated with lymph node content and were identified as potential markers of lymph nodes. These three markers were combined to create a binary logistic regression model, and a combined‐factor exceeding 0.75 was ultimately identified as a marker for pork adulteration with lymph nodes. The desorption electrospray ionization‐MS images showed that PGE2 had a higher relative abundance in the lymph node region than in adjacent non‐lymph node regions, indicating that PGE2 was a marker that contributed significantly for identifying lymph nodes adulteration into pork. Our results provide a theoretical basis for identifying lymph node adulteration, which will contribute to combating fraud in the meat industry.
Accounting and silence: The unspeakable, the unsaid, and the inaudible
Authors: Drujon d'Astros Caecilia , Morales Jérémy , Leca Bernard 
Published: March 2024

AbstractThis paper studies accounting and silence. Building on studies of accounting talk and introducing theories of “silencing,” we highlight the role of accounting silences in the production of engaging organizational conversations. Through a qualitative case study, we identify three forms of silence—the unspeakable, the unsaid, and the inaudible—and their links to accounting. Silences create motivations to engage in further accounting talk, but they also deny certain groups a voice in those conversations. An impression of participation, openness, and transparency emerges despite unequal access and the silencing of certain groups. Accounting itself can be silenced to avoid uncomfortable topics, potential problems, and anxiety‐inducing uncertainties. This silencing may serve to preserve a useful ignorance, avoid being in the know, and build alluring narratives and engaging conversations. Accounting silences sustain such conversations by protecting them from alternative voices, unsettling knowledge, and narratives that are incompatible with the organization's preferred story.
Shareholder perceptions of external tax advisors in corporate tax planning
Authors: Donohoe Michael P. , Gale Brian T. , Mayberry Michael A. 
Published: March 2024

AbstractWe examine shareholders' perceptions about how external tax advisors contribute to corporate tax planning. As residual claimants of corporate tax planning, shareholders benefit from lower corporate taxes, but also bear the financial and reputational costs of subsequent tax enforcement. Despite the influential advisory role of external tax advisors in corporate tax planning, existing research on how shareholders perceive this role is limited. Using event study methods and exploiting the heightened regulation of tax advice through the covered opinion rules as a setting, we observe average and cross‐sectional stock returns consistent with shareholders perceiving external tax advisors as contributing unfavorably to tax planning by promoting excessively risky strategies. We further find that risky and overall tax planning declined across firms after the enactment of the rules, consistent with shareholders' perceptions about tax advisors' contributions to firms' tax planning. Overall, our findings contribute to research on shareholder perceptions and valuation of tax planning, and have important implications for practice, where regulatory oversight of external tax advisors remains a significant concern.
Decreased oxytocin levels related to social cognition impairment in borderline personality disorder
Authors: Galvez‐Merlin Alejandra , López‐Villatoro José M. , de la Higuera‐González Pilar , de la Torre‐Luque Alejandro , McDowell Karina , Díaz‐Marsá Marina , Leza Juan C. , Carrasco José L. 
Published: March 2024

AbstractIntroductionDysfunctions in the oxytocin system have been reported in patients with borderline personality disorder (BPD). Deficits could be related to interpersonal hypersensitivity, which has been previously associated with failures in social cognition (SC) in this disorder, especially in Theory of Mind (ToM) skills. The aim of this work is to study the links between the oxytocin system and SC impairments in patients with BPD.MethodPlasma oxytocin levels (OXT) and protein expression of oxytocin receptors in blood mononuclear cells (OXTR) were examined in 33 patients with a diagnosis of BPD (age: M 28.85, DT = 8.83). Social cognition was assessed using the Movie for the Assessment of Social Cognition (MASC). Statistical associations between biochemical factors and different response errors in MASC were analyzed through generalized linear regression controlling for relevant clinical factors.ResultsGeneralized linear regression showed a significant relationship between lower OXTR and overmentalization in BPD patients (OR = 0.90).ConclusionsThis work supports the relationship between alterations in the oxytocin system and ToM impairments observed in BPD patients, enhancing the search for endophenotypes related to the phenotypic features of the disorder to improve current clinical knowledge and address more specific therapeutic targets.
The direct and indirect effects of cash transfer program on the consumption of nutrients: Evidence from Kenya
Authors: Ongudi Silas , Thiam Djiby , Miranda Mario J. , Abdoul Sam 
Published: March 2024

AbstractHow does the receipt of a cash transfer impact consumption of nutrients, vitamins, and minerals in households? To answer this question, we use a randomized controlled trial dataset from Hunger Safety Net Program (HSNP) with 9,246 households spread across the four districts (Turkana, Marsabit, Wajir, and Mandera) of Kenya. In the experiment, HSNP treated households received a bi‐monthly cash transfer of about United States of America Dollar (USD) 20 relative to households in control sub‐locations. Using difference in‐difference specification, we find that HSNP poor beneficiary households in treated households increased (by approximately 96%, 50%, and 61%) the consumption of vitamins A, C, and beta carotene, respectively compared to those in control sub‐locations. Moreover, HSNP non‐poor, non‐beneficiary households residing in treated sub‐locations increased (by about 70% and 46%) the consumption of vitamin A and Beta carotene, respectively compared to those in control sub‐locations. In addition, HSNP‐poor beneficiary households in treated sub‐locations sourced most of their nutrients, vitamins, and minerals from the market. We rule out alternative pathways that could potentially increase consumption and conclude that a rise in consumption amongst HSNP non‐poor, non‐beneficiary households is due to sharing of HSNP transfer amongst social network members.