bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole-family programmes for families living with parental mental illness: a systematic review and meta-analysis
Authors: Moltrecht B. , Lange Aurelie M. C. , Merrick H. , Radley J. 
Published: February 2024

AbstractSeveral interventions have been developed to support families living with parental mental illness (PMI). Recent evidence suggests that programmes with whole-family components may have greater positive effects for families, thereby also reducing costs to health and social care systems. This review aimed to identify whole-family interventions, their common characteristics, effectiveness and acceptability. A systematic review was conducted according to PRISMA 2020 guidelines. A literature search was conducted in ASSIA, CINAHL, Embase, Medline, and PsycINFO in January 2021 and updated in August 2022. We double screened 3914 abstracts and 212 papers according to pre-set inclusion and exclusion criteria. The Mixed Methods Appraisal Tool was used for quality assessment. Quantitative and qualitative data were extracted and synthesised. Randomised-control trial data on child and parent mental health outcomes were analysed separately in random-effects meta-analyses. The protocol, extracted data, and meta-data are accessible via the Open Science Framework (https://osf.io/9uxgp/). Data from 66 reports—based on 41 independent studies and referring to 30 different interventions—were included. Findings indicated small intervention effects for all outcomes including children’s and parents’ mental health (dc = −0.017, −027; dp = −0.14, −0.16) and family outcomes. Qualitative evidence suggested that most families experienced whole-family interventions as positive, highlighting specific components as helpful, including whole-family components, speaking about mental illness, and the benefits of group settings. Our findings highlight the lack of high-quality studies. The present review fills an important gap in the literature by summarising the evidence for whole-family interventions. There is a lack of robust evidence coupled with a great need in families affected by PMI which could be addressed by whole-family interventions. We recommend the involvement of families in the further development of these interventions and their evaluation.
Comparative plastome analysis and taxonomic classification of snow lotus species (Saussurea, Asteraceae) in Central Asia and Southern Siberia
Authors: Nyamgerel Nudkhuu , Baasanmunkh Shukherdorj , Oyuntsetseg Batlai , Tsegmed Zagarjav , Bayarmaa Gun-Aajav , Lazkov Georgy , Pyak Elizaveta , Gil Hee-Young , Park Inkyu , Choi Hyeok Jae 
Published: February 2024

AbstractFour species of Saussurea, namely S. involucrata, S. orgaadayi, S. bogedaensis, and S. dorogostaiskii, are known as the “snow lotus,” which are used as traditional medicines in China (Xinjiang), Kyrgyzstan, Mongolia, and Russia (Southern Siberia). These species are threatened globally, because of illegal harvesting and climate change. Furthermore, the taxonomic classification and identification of these threatened species remain unclear owing to limited research. The misidentification of medicinal species can sometimes be harmful to health. Therefore, the phylogenetic and genomic features of these species need to be confirmed. In this study, we sequenced five complete chloroplast genomes and seven nuclear ITS regions of four snow lotus species and other Saussurea species. We further explored their genetic variety, selective pressure at the sequence level, and phylogenetic relationships using the chloroplast genome, nuclear partial DNA sequences, and morphological features. Plastome of the snow lotus species has a conserved structure and gene content similar to most Saussurea species. Two intergenic regions (ndhJ–ndhK and ndhD-psaC) show significantly high diversity among chloroplast regions. Thus, ITS and these markers are suitable for identifying snow lotus species. In addition, we characterized 43 simple sequence repeats that may be useful in future population genetic studies. Analysis of the selection signatures identified three genes (rpoA, ndhB, and ycf2) that underwent positive selection. These genes may play important roles in the adaptation of the snow lotus species to alpine environments. S. dorogostaiskii is close to S. baicalensis and exhibits slightly different adaptation from others. The taxonomic position of the snow lotus species, confirmed by morphological and molecular evidence, is as follows: (i) S. involucrata has been excluded from the Mongolian flora due to misidentification as S. orgaadayi or S. bogedaensis for a long time; (ii) S. dorogostaiskii belongs to section Pycnocephala subgenus Saussurea, whereas other the snow lotus species belong to section Amphilaena subgenus Amphilaena; and (iii) S. krasnoborovii is synonymous of S. dorogostaiskii. This study clarified the speciation and lineage diversification of the snow lotus species in Central Asia and Southern Siberia.
Assessing supervisor versus trainee viewpoints of entrustment through cognitive and affective lenses: an artificial intelligence investigation of bias in feedback
Authors: Gin Brian C. , ten Cate Olle , O’Sullivan Patricia S. , Boscardin Christy 
Published: February 2024

AbstractThe entrustment framework redirects assessment from considering only trainees’ competence to decision-making about their readiness to perform clinical tasks independently. Since trainees and supervisors both contribute to entrustment decisions, we examined the cognitive and affective factors that underly their negotiation of trust, and whether trainee demographic characteristics may bias them. Using a document analysis approach, we adapted large language models (LLMs) to examine feedback dialogs (N = 24,187, each with an associated entrustment rating) between medical student trainees and their clinical supervisors. We compared how trainees and supervisors differentially documented feedback dialogs about similar tasks by identifying qualitative themes and quantitatively assessing their correlation with entrustment ratings. Supervisors’ themes predominantly reflected skills related to patient presentations, while trainees’ themes were broader—including clinical performance and personal qualities. To examine affect, we trained an LLM to measure feedback sentiment. On average, trainees used more negative language (5.3% lower probability of positive sentiment, p < 0.05) compared to supervisors, while documenting higher entrustment ratings (+ 0.08 on a 1–4 scale, p < 0.05). We also found biases tied to demographic characteristics: trainees’ documentation reflected more positive sentiment in the case of male trainees (+ 1.3%, p < 0.05) and of trainees underrepresented in medicine (UIM) (+ 1.3%, p < 0.05). Entrustment ratings did not appear to reflect these biases, neither when documented by trainee nor supervisor. As such, bias appeared to influence the emotive language trainees used to document entrustment more than the degree of entrustment they experienced. Mitigating these biases is nonetheless important because they may affect trainees’ assimilation into their roles and formation of trusting relationships.
Study of an Enterococcus faecium strain isolated from an artisanal Mexican cheese, whole-genome sequencing, comparative genomics, and bacteriocin expression
Authors: Acero-Pimentel Daniel , Romero-Sánchez Diana I. , Fuentes-Curiel Sac Nicté , Quirasco Maricarmen 
Published: February 2024

AbstractEnterococci are ubiquitous microorganisms in almost all environments, from the soil we step on to the food we eat. They are frequently found in naturally fermented foods, contributing to ripening through protein, lipid, and sugar metabolism. On the other hand, these organisms are also leading the current antibiotic resistance crisis. In this study, we performed whole-genome sequencing and comparative genomics of an Enterococcus faecium strain isolated from an artisanal Mexican Cotija cheese, namely QD-2. We found clear genomic differences between commensal and pathogenic strains, particularly in their carbohydrate metabolic pathways, resistance to vancomycin and other antibiotics, bacteriocin production, and bacteriophage and CRISPR content. Furthermore, a bacteriocin transcription analysis performed by RT-qPCR revealed that, at the end of the log phase, besides enterocins A and X, two putative bacteriocins not reported previously are also transcribed as a bicistronic operon in E. faecium QD-2, and are expressed 1.5 times higher than enterocin A when cultured in MRS broth.
Progress of Ferroptosis in Ischemic Stroke and Therapeutic Targets
Authors: Tian Xinjuan , Li Xiang , Pan Mengtian , Yang Lele Zixin , Li Yunman , Fang Weirong 
Published: February 2024

AbstractFerroptosis is an iron-dependent form of programmed cell death (PCD) and ischemic stroke (IS) has been confirmed to be closely related to ferroptosis. The mechanisms of ferroptosis were summarized into three interrelated aspects: iron metabolism, lipid peroxide metabolism, as well as glutathione and amino acid metabolism. What’s more, the causal relationship between ferroptosis and IS has been elucidated by several processes. The disruption of the blood–brain barrier, the release of excitatory amino acids, and the inflammatory response after ischemic stroke all lead to the disorder of iron metabolism and the antioxidant system. Based on these statements, we reviewed the reported effects of compounds and drugs treating IS by modulating key molecules in ferroptosis. Through detailed analysis of the roles of these key molecules, we have also more clearly demonstrated the essential effect of ferroptosis in the occurrence of IS so as to provide new targets and ideas for the therapeutic targets of IS.
Graphical Abstract
Three abnormal cell metabolism pathways contribute to ferroptosis after ischemic stroke, and many key regulatory compounds in ferroptosis can play important therapeutic roles.
Iron Deposition in Parkinson’s Disease: A Mini-Review
Authors: Zeng Weiqi , Cai Jin , Zhang Lei , Peng Qiwei 
Published: February 2024

AbstractIron deposition is crucial pathological changes observed in patients with Parkinson's disease (PD). Recently, scientists have actively explored therapeutic approaches targeting iron deposition in PD. However, several clinical studies have failed to yield consistent results. In this review, we provide an overview of iron deposition in PD, from both basic research and clinical perspectives. PD patients exhibit abnormalities in various iron metabolism-related proteins, leading to disruptions in iron distribution, transport, storage, and circulation, ultimately resulting in iron deposition. Excess iron can induce oxidative stress and iron-related cell death, and exacerbate mitochondrial dysfunction, contributing to the progression of PD pathology. Magnetic resonance imaging studies have indicated that the characteristics of iron deposition in the brains of PD patients vary. Iron deposition correlates with the clinical symptoms of PD, and patients with different disease courses and clinical presentations display distinct patterns of iron deposition. These iron deposition patterns may contribute to PD diagnosis. Iron deposition is a promising target for PD treatment. However, further research is required to elucidate the underlying mechanisms and their impacts on PD.
Graphical Abstract
Iron deposition in the Substantia nigra (SN) is a crucial pathological alteration in Parkinson's disease (PD). This article provides a review of the mechanisms and effects of iron deposition, as well as research on brain iron deposition in PD patients using magnetic resonance imaging (MRI). These findings elucidate the role of iron deposition in PD.
Readiness, resilience, and engagement:
Analyzing the core building blocks of online education
Authors: Polat Mustafa 
Published: February 2024

AbstractContemporary educational research has increasingly highlighted the
necessity and significance of online education and its effects on student engagement
and academic success. However, it’s noteworthy that there is still a gap in the
growing literature regarding the student-related factors that influence individuals’
engagement and achievement in online education. This study sought to investigate the
effects of students’ online learning readiness in online learning engagement with
the mediating role of academic resilience in this relationship. A cross-sectional
survey design was employed based on the data from a total of 3550 undergraduates
studying at state universities in six provinces across the eastern, central, and
western regions of Türkiye. Structural equation modeling was conducted to estimate
the complex relationships proposed in the model through AMOS 26. The findings
demonstrated that students’ online learning readiness has a moderate but
statistically significant direct effect on engagement in online learning, as well as
had a significant and moderate effect on academic resilience. Furthermore, the
results indicated that academic resilience plays a crucial role as a significant
mediator in the relationship between students’ online learning readiness and online
learning engagement. The current study also confirmed the conceptual model built on
the variables that have notable impacts on students’ academic achievement. This
research, one of the first in its field, furnishes empirical evidence on a
conceptualized set of relationships and offers insights for policy makers,
curriculum developers and practitioners to consider the significant student-related
factors in terms of design, development, and delivery of online courses.
Facilitating learning and interaction in K-12 remote teaching contexts
Authors: Skog Simon , Pettersson Fanny , From Jörgen 
Published: February 2024

AbstractThe use of a facilitator is a growing phenomenon in K-12 remote teaching contexts. The aim of this study is to analyse aspects of facilitating students’ learning and interaction, with a special focus on the role of the facilitator. Frame factor theory was used as an analytical framework, including different educational conditions. The following research questions were posed: (1) How do different frame factors condition remote teaching? (2) How do these frame factors influence the role of the facilitator in remote teaching? Data were generated from observations (12 h) and interviews with remote teachers and facilitators (N = 18). Results show that frame factors seem to create two types of classroom context that condition the role, task, and responsibility of the facilitator. In the larger classroom context, the facilitator was a threefold resource - practical, pedagogical, and social in an ongoing collaboration with the teacher, whereas in the small classroom context, the facilitator mainly was a practical resource when needed.
A Longitudinal Study of Children’s Digital Play Addiction Tendencies and Parental Guidance Strategies
Authors: Işıkoğlu Nesrin , Budak Kadriye Selin , Guzen Müzeyyen 
Published: February 2024

Abstract
The current study aims to identify changing trends in digital play addiction tendencies among young children and parental guidance strategies before, during, and after the COVID-19 pandemic. In light of the bioecological model of development, it was hypothesized that the pandemic would have a significant impact on the addiction to digital play among young children. The participants of this longitudinal trend study were 1552 parents with children from 4 to 6 years of age who attended public preschools or kindergartens in Denizli, Turkey—data was collected through the Digital Play Addiction Tendency and Digital Play Parental Mediation Scale. The results revealed that children’s digital play addiction increased during the pandemic and declined post-pandemic. Moreover, both significant changes and stability were observed in parental digital play guidance strategies. Specifically, parental control over their children’s digital activities has decreased over time. Results are discussed in relation to the literature, with implications explored for future research and parents.
Residential exposure to mold, dampness, and indoor air pollution and risk of respiratory tract infections: a study among children ages 11 and 12 in the Danish National Birth Cohort
Authors: Groot Jonathan , Keller Amélie , Sigsgaard Torben , Loft Steffen , Nybo Andersen Anne-Marie 
Published: February 2024

Abstract
Background
The burden of respiratory tract infections (RTIs) is high in childhood. Several residential exposures may affect relative rates.

Objectives
To determine risk of RTIs in children ages 11 and 12 by residential exposures.

Methods
We included children in the Danish National Birth Cohort (DNBC) at ages 11 and 12. We estimated incidence risk ratios (IRR) and 95% confidence intervals (CI) for counts of RTIs within the last year by exposure to mold/dampness, gas stove usage, summer and winter candle-burning, fireplace usage, cats and dogs indoors, and farmhouse living. We also estimated IRR and 95% CI for RTIs for predicted scores of four extracted factors (‘owned house’, ‘mold and dampness’, ‘candles’, and ‘density’) from exploratory factor analyses (EFA).

Results
We included 42 720 children with complete data. Mold/dampness was associated with all RTIs (common cold: IRRadj 1.09[1.07, 1.12]; influenza: IRRadj 1.10 [1.05, 1.15]; tonsillitis: IRRadj 1.19 [1.10, 1.28]; conjunctivitis: IRRadj 1.16 [1.02, 1.32]; and doctor-diagnosed pneumonia: IRRadj 1.05 [0.90, 1.21]), as was the EFA factor ‘mold/dampness’ for several outcomes. Gas stove usage was associated with conjunctivitis (IRRadj 1.25 [1.05, 1.49]) and with doctor-diagnosed pneumonia (IRRadj 1.14 [0.93, 1.39]). Candle-burning during summer, but not winter, was associated with several RTIs, for tonsillitis in a dose-dependent fashion (increasing weekly frequencies vs. none: [IRRadj 1.06 [0.98, 1.14], IRRadj 1.16 [1.04, 1.30], IRRadj 1.23 [1.06, 1.43], IRRadj 1.29 [1.00, 1.67], and IRRadj 1.41 [1.12, 1.78]).

Conclusion
Residential exposures, in particular to mold and dampness and to a lesser degree to indoor combustion sources, are related to the occurrence of RTIs in children.
CMB, Hawking, Planck, and Hubble Scale Relations Consistent with Recent Quantization of General Relativity Theory
Authors: Haug Espen Gaarder 
Published: February 2024

AbstractWe are demonstrating new relationships among the Hawking temperature, the Cosmic Microwave Background (CMB) temperature, and the Planck scale. When understood deeply, these are in line with recent advancements in cosmological quantization and its connection to the Planck scale. This is also completely consistent with a recently published method for quantizing Einstein’s general theory of relativity.
A note on “Largest independent sets of certain regular subgraphs of the derangement graph”
Authors: Filmus Yuval , Lindzey Nathan 
Published: February 2024

AbstractLet $$D_{n,k}$$

D

n
,
k

be the set of all permutations of the symmetric group $$S_n$$

S
n

that have no cycles of length i for all $$1 \le i \le k$$

1
≤
i
≤
k

. In the paper mentioned above, Ku, Lau, and Wong prove that the set of all the largest independent sets of the Cayley graph $$\text {Cay}(S_n,D_{n,k})$$

Cay
(

S
n

,

D

n
,
k

)

is equal to the set of all the largest independent sets in the derangement graph $$\text {Cay}(S_n,D_{n,1})$$

Cay
(

S
n

,

D

n
,
1

)

, provided n is sufficiently large in terms of k. We give a simpler proof that holds for all n, k and also applies to the alternating group.
Examining the Process and Impact of Social Problem Solving in Autistic Children
Authors: McNair Morgan L. , Mondejar Victoria , Libsack Erin J. , Mordekai Nicole H. , McKown Clark , Russo-Ponsaran Nicole M. , Lerner Matthew D. 
Published: February 2024

Abstract
Social problem solving (SPS) represents a social cognitive reasoning process that gives way to behavior when individuals are navigating challenging social situations. Autistic individuals have been shown to struggle with specific aspects of SPS, which, in turn, has been related to social difficulties in children. However, no previous work has measured how SPS components not only relate to one another but also discretely and conjointly predict autism-related symptoms and social difficulties in autistic children, specifically. Fifty-eight autistic children (44 male; 6–10 years old, M

age
=8.67, SD

age
=1.31) completed a self-administered, computerized assessment of SPS. To elucidate how SPS components discretely, and combined, contribute to autism-related symptoms and social difficulties, commonality analyses were conducted for each measure assessing autism-related symptoms and social difficulties. Socially normative problem identification, goal preference, and solution preference were related to fewer parent-reported autism-related social difficulties. Measures related to autism symptomatology, social perspective taking, and emotion recognition were not significantly associated with discrete SPS components in this sample. The problem identification aspect of SPS contributed the most unique variance to parent-reported autism-related social difficulties, while shared variance across all SPS components accounted for substantial variance in both parent-reported autism-related social difficulties models. Results suggest that SPS components are interrelated, but distinct, constructs in the autistic population. These findings not only further clarify the impact of SPS components on autism-related symptoms and social difficulties, but also have implications for refining SPS-focused interventions in the autistic population.
Schizophrenia in Autistic People with Intellectual Disabilities. Treatment and Interventions
Authors: Bakken Trine Lise , Askeland Hellerud Jane Margrete , Kildahl Arvid Nikolai , Solheim-Inderberg Ann Magritt , Hove Oddbjørn , Berge Helverschou Sissel 
Published: February 2024

AbstractAutistic people with intellectual disabilities appear to be at increased risk of schizophrenia. While current recommendations emphasize adapting interventions used for people with schizophrenia in general, few studies to date have investigated treatment of co-occurring schizophrenia in this specific population. To explore what interventions are provided to autistic people with intellectual disabilities and co-occurring schizophrenia in specialized mental health services, and to investigate whether changes in mental health symptoms and challenging behavior occurred during treatment. Using data from a longitudinal, national multicenter study, interventions provided to 26 autistic individuals with intellectual disabilities and co-occurring schizophrenia were explored. Symptoms were measured using the Psychopathology in Autism Checklist (PAC) and the Aberrant Behavior Checklist ABC) at referral (T1), at the end of treatment (T2), and at follow-up 12 months after T2 (T3). A broad range of interventions were provided to the participants, including inpatient admission, psychopharmacological treatment, various psychosocial interventions, and supportive interventions. Scores on the PAC and ABC were significantly lower at T2 than T1 for most scales, and no significant change was found from T2 to T3.Treatment of co-occurring schizophrenia appears feasible and effective in autistic people with intellectual disabilities.
Joke economics: the low profile of comedy in the economics of arts and culture
Authors: Collins Alan 
Published: February 2024

AbstractDespite being a globally significant form of art and culture, the performance of comedy has seemingly maintained a very low profile in cultural economics. The case for greater research scrutiny of this art form is advanced alongside some possible reasons for the relatively low academic attention devoted to comedy. The scope for considering comedy in economic terms is also considered, and a range of research questions are raised to stimulate debate and further enquiry on the topic.