bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental investigation on bi-component wall film evaporation on a hot wall
Authors: Yan Yan'an , He Yushuo , Fei Chunguang , Zhang Qifan 
Published: April 2024

Abstract

Spray-wall impingement is a widely observed phenomenon in modern internal combustion engines. The formation and evaporation of the wall film significantly impacts the fuel-air formation as well as combustion and exhaust pollutants. In this study, fuel film evaporation experiments were carried out under a constant wall temperature condition for n-decane, n-dodecane, and their blends in order to gain a better knowledge of film evaporation characteristics. Moreover, the effects of wall temperature and mass ratio of mixed fuels on wall film thickness, area, volume, and lifespan were investigated. Furthermore, it was found an unexpected phenomenon in which the lifetime of the bi-component fuel film might be shorter than that of the pure n-decane fuel film under certain operating conditions. Finally, the processed data provided solid data to validate the unsteady one-dimensional analytical models.
Optimal Control Strategies for Sustainable Energy Management in Electric Power Grids: A Hybrid Model Predictive Approach
Authors: Roudaki SeyedHamed MirMohammadAli , Yazdani Kaveh 
Published: April 2024

Abstract

Energy infrastructure development in rural and remote areas of the planet is key to sustaining human development. This study establishes an optimal control strategy that can efficiently manage an electric grid comprised of various renewable and non-renewable energy sources for a medium sized community. Simple power dynamics are modeled and used for representing the components present on the grid. A hybrid model predictive control scheme is implemented for choosing an optimal mode and set of inputs for the system for tracking both a constant and load-varying power demand profile.
Major depressive disorder, neuroticism, suicidal behaviors, and depression severity are all associated with neurotoxic immune networks and their intricate interactions with metabolic syndrome.
Authors: Maes Michael , Jirakran Ketsupar , Vasupanrajit Asara , Zhou Bo , Tunvirachaisakul Chavit , Almulla Abbas F. 
Published: April 2024

Abstract
Background
Major depressive disorder (MDD) is considered to be a neuroimmune disorder. However, there are no data regarding the association between comprehensive immune profiles and their interactions with the metabolic syndrome (MetS) in predicting neuroticism, suicidal behaviors, and severity of outpatient MDD (OMDD).
Methods
We assayed 48 serum cytokines, chemokines, and growth factors using a multiplex assay in 67 healthy controls and 66 OMDD patients. Around 50% of the OMDD and control participants had a diagnosis of MetS.
Results
Ten differentially expressed proteins (DEPs) were upregulated in OMDD (i.e., CXCL12, TNFB, PDGF, CCL11, IL9, IL4, CCL5, CCL2, CCL4, IL1RN), indicating an immune, defense and stress response. Six DEPs were downregulated (VEGFA, IL12, CCL3, CSF1, IL1B, NGF), indicating lowered neurogenesis and regulation of neuron death. Significant interactions between OMDD and MetS caused a) substantial increases in TNF signaling, and upregulation of IL4, IL17, TNF, TNFB, CCL2, CCL5, PDGF, IL1RN; and b) downregulation of VEGFA and FGF. A large part of the variance in neuroticism (26.6%), suicidal behaviors (23.6%), and the MDD phenome (31.4%) was predicted by immunological data and interactions between MetS and CCL5, TNFB or VEGFA.
Discussion
OMDD is characterized by an immunoneurotoxic profile which partly explains neuroticism, suicidal behaviors, and the phenome’s severity. Lowered IL-10 and increased neurotoxicity are characteristics of OMDD and other depression phenotypes, including severe first-episode inpatient MDD. The presence of MetS in OMDD considerably exacerbates immunoneurotoxicity. Consequently, immune studies in MDD should always be performed in subjects with and without MetS.
Surface water contamination with Acanthamoeba spp. in Ilam city, Iran
Authors: Ghadesi Azadeh , Hasanpour Hamid , Naserifar Razi , Abdi Jahangir , Mahmoudi Mohammad Reza , Turki Habibollah , Raiesi Omid , Getso Muhammad Ibrahim , Mirzaei Asad 
Published: April 2024

Abstract

Acanthamoeba, a widely distributed free-living amoeba with 20 genotypes identified through rRNA gene sequencing, exhibits varying degrees of pathogenicity influenced by its genotype. This study focuses on assessing the prevalence of Acanthamoeba species in the surface waters of Ilam, located in western Iran, utilizing morphological analysis and sequencing of the 18S rRNA gene through the PCR method. A total of 50 water samples were collected from various regions within Ilam city, situated in the southwest of Iran. To isolate Acanthamoeba parasites from the samples, a culture method was used, and all utilized culture media were scrutinized through microscopic and molecular techniques. The parasite's genotype was determined by sequencing a 500-bp fragment of the 18S rRNA gene. Using microscopic and molecular methods, 19 and 16 water samples tested positive, respectively. The 18S rRNA sequences revealed that the isolates belonged to the T4, T2, and T11 genotypes. This study emphasizes the presence and inclination for close contact with highly pathogenic genotypes of Acanthamoeba in the surface waters of Ilam City.
Evaluación de dos complejos enzimáticos en dietas de postura sobre la reproducción de la Codorniz Japonesa
Authors: Cumpa G. Marcial , Chia G. Liu 
Published: April 2024

Un experimento fue llevado a cabo con el objetivo de evaluar el efecto de la adición de dos complejos enzimáticos a dietas de codornices reproductoras. 135 codornices japonesas (90 hembras y 45 machos) fueron asignadas durante 56 días en 3 tratamientos: T-1 (Control), T-2 (con adición de celulasa y proteasa) y T-3 (con adición de amilasa, xilanasa y proteasa). Los resultados del experimento no mostraron diferencias significativas entre tratamientos en producción de huevos, masa de huevo, peso de huevo, consumo de alimento, conversión alimenticia, fertilidad, incubabilidad, natalidad y peso de codorniz BB. Al análisis de la retribución económica del alimento se determinó que la mayor eficiencia la obtuvo el tratamiento 1, sin suplementación de enzimas.
Evaluación del diámetro, longitud y rendimiento al lavado de la fibra de Vicuña en el Patronato del Parque de las Leyendas
Authors: Trejo C. Wilder , Baquerizo R. Maite , Palacios P. Gloria 
Published: April 2024

El presente trabajo se ha llevado a cabo con 35 animales, 19 machos y 16 hembras, pertenecientes al Patronato del Parque de las Leyendas en Lima - Perú. El objetivo ha sido determinar el diámetro de fibra, longitud de fibra y rendimiento al lavado de tres zonas corporales del animal (paleta, costillar y grupa). El promedio general del diámetro de fibra fue de 11.23 ± 2.25 µ; con un coeficiente de variabilidad de 20.02%. El diámetro correspondiente a las tres zonas estudiadas han reportado valores de 11.15 ± 2.25 µ para la zona de paleta, 11.25 ± 2.25 µ para la zona de costillar medio y un valor de 11.31 ± 2.22 µ para la zona de grupa, el vellón de la vicuña es homogénea pues no presenta diferencias significativas; lo cual impide encontrar una zona representativa para el muestreo del diámetro; en cuanto a la diferencia de sexo, se ha encontrado que las hembras tienen un diámetro promedio de 11.35 ± 2.32 µ, mientras que los machos tienen 11.10 ± 3.32µ. También se realizó la curva de distribución de frecuencia la cual nos indica que el 81.73% de la fibra se encuentra por debajo del promedio (11.23 µ). Para el caso de la longitud de fibra el promedio encontrado ha sido de 0.94±0.54 pulg., con un coeficiente de variabilidad de 62.12%. Para el promedio por de 62.12%. Para el promedio por zonas registró que la zona del costillar medio es la más larga con una longitud de 1.02 ± 0.56 pulgadas seguida de la zona de grupa con 0.97 ± 0.56 pulgadas y la zona de menor largo es la zona de paleta con 0.82 ± 0.45 pulg. La curva de distribución de frecuencia nos indica que el 58.47% de la fibra se encuentra por debajo de 0.94 pulgadas. En cuanto a la longitud para los sexos hay una alta diferencia significativa (P<0.01) entre las hembras con 1.19 ± 0.63 pulg., y los machos con 0.70 ± 0.44 pulg. El rendimiento al lavado nos reporta un rendimiento de 72.67%. Para el rendimiento de acuerdo al sexo se tiene que las hembras tienen un rendimiento de 77.46% y los machos 67.88% con alta diferencia significativa (P<0.01). Palabras
Problema de Valor Inicial para un Sistema Dispersivo No Lineal de Ondas Largas Regularizado
Authors: Mendoza U. Aldo 
Published: April 2024

En este trabajo de investigación, estudiaremos el sistema de ecuaciones no lineales dispersivas bajo el efecto de disipación, es un número entero. Nuestro objetivo es demostrar que el sistema dispersivo o problema de Cauchy, esta bien formulado localmente y globalmente. Por esta razón vemos varias propiedades de las soluciones reales.
Análisis de Productividad y Costos en la Fabricación de Pisos de Shihuahuaco (Dipteryx spp.)
Authors: Vidal M. Mariana , Chuquicaja S. Carlos , Meléndez C. Miguel 
Published: April 2024

Se analiza el rendimiento y productividad, así como se determina la estructura de costos del proceso de transformación de la madera Dipteryx spp. de tablones a tablillas de piso deck en una empresa maderera de la ciudad de Pucallpa. El rendimiento de la materia prima se halla en base a una muestra de 106 tablones; el estudio de tiempos así como el análisis y cálculo de costos se realizan en base a una orden de trabajo por 20 m3 de pisos. Se encontró un rendimiento de tablón a producto de 29,12%, con un desperdicio del 58.81% luego de recuperar el 11.07% del volumen inicial de los tablones. Se determinó que para la producción de un contenedor de 20 m3 de decks considerando un turno diario, se requieren 30 días laborables: 13 turnos de trabajo y 17 días adicionales para el secado de la madera. El costo de un metro cúbico de piso tipo deck en madera shihuahuaco es de US$ 762; en caso no asignar los costos fijos dicho costo disminuye a US$ 699.
Nulidad del Acto Jurídico
Authors: Ardiles R. Grecia 
Published: April 2024

El presente trabajo de investigación fue realizado aplicando la escuela metodológica del Sincretismo de Carnelutti, el cual consiste en la ubicación histórica del tema (Nulidad del Acto Jurídico) y su evolución. Así como punto importante del planteamiento de ésta escuela metodológica, es la búsqueda del dato, la cual nosotros la hemos ubicado en la voluntad, puesto que, la voluntad es lo que direcciona el sentido de nuestros actos y desemboca por consiguiente en consecuencias jurídicas. El objeto de la presente investigación es poder establecer el avance conceptual de la nulidad del acto jurídico, puesto que, a la fecha un acto se reputa como nulo, porque encuentra un defecto en su estructura. Asimismo como principal conclusión podemos resaltar que la Legislación Civil Peruana vigente, trata como sinónimos a los términos nulidad e invalidez, teniendo cada uno de éstos definiciones distintas, dado que, la invalidez constituye el género y la nulidad una especie, por lo que, es errada la asignación de nulidad como sinónimo de invalidez en la normativa civil peruana, conllevando por lo cual a una confusión en el sistema jurídico.
Lo absurdo y lo fantástico en los cuentos de Julio Ramón Ribeyro
Authors: Vega M. Nehemías 
Published: April 2024

La narrativa fantástica de Julio Ramón Ribeyro está integrada por un grupo pequeño de cuentos, quizás por ello ha sido poco estudiada por la crítica literaria peruana y extranjera que ha preferido analizar sus cuentos realistas. La mayoría de los estudios sobre la narrativa fantástica de Ribeyro comete errores al considerar algunos cuentos absurdos como fantásticos. El presente trabajo mostrará la diferencia entre lo fantástico y lo absurdo para así evitar la confusión entre ambas modalidades que Ribeyro trabaja en su narrativa corta. Para ello, analizaremos los cuentos “La insignia”, “Silvio en El Rosedal”, “Doblaje” y “Ridder y el pisapapeles”.
Evaluación del pardeamiento enzimático durante el almacenamiento en congelación del puré de Palta (Persea americana Mill) Var. Hass.
Authors: Hernández M. Ernesto , Briceño B. Luis 
Published: April 2024

Con la finalidad de prolongar su tiempo de conservación, pulpa refinada de palta variedad Hass fue tratada con antioxidantes ( mezcla de ácido cítrico y ácido ascórbico) y envasada al vacío y sin vacío, luego de lo cual fue almacenada en congelación (-18 ºC) durante 150 días. Al inicio y durante el almacenamiento se determinó la actividad enzimática de la polifenoloxidasa (PFO) y se evaluó el color de la pulpa en base al sistema de coordenadas de cromaticidad L, a y b. Durante el almacenamiento se evaluó también el pH y las características sensoriales. Se encontraron altas reducciones de actividad de la PFO cuando el ácido cítrico y el ácido ascórbico fueron adicionados como aditivos. El puré con alta disminución de la actividad de la PFO fue menos sensible al cambio de color, el que se manifestó por la pérdida de la luminosidad original y el verdor de la pulpa. Los aditivos utilizados fueron los factores que más evitaron las reacciones de pardeamiento.
Structural Perspectives in the Development of Novel EGFR Inhibitors for
the Treatment of NSCLC
Authors: Makhija Rahul , Sharma Anushka , Dubey Rahul , Asati Vivek 
Published: April 2024

Abstract:
Non-small cell Lung cancer (NSCLC) is the most common type of lung cancer, which is
caused by high consumption of tobacco and smoking. It is an epithelial lung cancer that affects
about 2.2 million people across the globe, according to International Agency for Research on Cancer
(IARC). Non-small cell lung cancer is a malignant tumor caused by EGFR mutation that occurs
in the in-frame deletion of exon 19 and L858R point mutation in exon 21. Presently, clinically
available inhibitors of EGFR (including erlotinib, lapatinib, gefitinib, selumetinib, etc.) are not specific
and responsible for undesirable adverse effects. Moreover, to solve this problem search for
newer EGFR inhibitors is the utmost need for the treatment and/or management of increasing lung
cancer burden. The discovery of therapeutic agents that inhibit the specific target in tumorous cells,
such as EGFR, is one of the successful strategies in treating many cancer therapies, including lung
cancer. The exhaustive literature survey (2018-2023) has shown the importance of medicinally privileged
pyrimidine derivatives together, fused and/or clubbed with other heterocyclic rings to design
and develop novel EGFR inhibitors. Pyrimidine derivatives substituted with phenylamine, indole,
pyrrole, piperazine, pyrazole, thiophene, pyridine and quinazoline derivatives substituted with phenylamine,
pyrimidine, morpholine, pyrrole, dioxane, acrylamide, indole, pyridine, furan, pyrimidine,
pyrazole etc. are privileged heterocyclic rings shown promising activity by inhibiting EGFR and
TKIs. The present review summarizes the structure-activity relationship (SAR) and enzyme inhibitory
activity, including IC50 values, percentage inhibition, and kinetic studies of potential compounds
from various literature. The review also includes various aspects of molecular docking studies
with compounds under clinical trials and patents filed on pyrimidine-based EGFR inhibitors in
treating non-small cell lung cancer. The present review may benefit the medicinal chemist for developing
novel compounds such as EGFR inhibitors.
Heteroaromatization of Coumarin Part II: Synthesis, Reactions, and Antimicrobial Activities of Novel Pyrido[2,3-d]pyrimidine Derivatives
Authors: Borik Rita M. A. , Abd El-Wahab Ashraf H. F. , Mohamed Hany M. , Ismail Khatib S. 
Published: April 2024

Background:
Condensation of 3-acetyl coumarin (1) with 2‐(4-methoxy- benzylidene)
malononitrile (2) in ammonium acetate/acetic acid or absolute ethanol/piperidine affords
pyridine (3) and chromen-2-one (4) derivatives, respectively.

Methods:
In this study, the reaction of 3 with an electrophilic reagent, namely, formic acid,
acetic anhydride and formamide afforded the pyridopyrimidinone and pyridine derivatives (6-
9). Also, treatment of 3 with different aromatic aldehydes, carbon disulfide, NaN3/NH4Cl, 2-
(4-methoxybenzylidene)malononitrile and acetophenone afforded pyridopyrimidinone, carbamodithioic
acid, tetrazol-5-yl-chromen-2-one, 2H-chromen-2-one, and pyridine derivatives
(10-14), respectively.

Results:
This study synthesized coumarins with antimicrobial activity and verified the structure
and purity of the synthesized compounds using spectral data.

Conclusion:
The new compounds were evaluated in vitro for their antimicrobial activity
against gram-positive bacteria (Staphylococcus aureus, Methicillin-resistant Staphylococcus
aureus) and gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), in addition
to fungus (Candida albicans). The investigated substances 3 and 14 presented good activity
against MRSA, E. coli, P. aeruginosa and C. albicans, while compounds 9, 10a-c, 11, 12 and
13 exhibited good to moderate activity.
Filtration of Natural Derivatives as MAO Inhibitors by Virtual Screening: A Potential Lead for Neurodegenerative Disorders
Authors: Malik Neelam , Agnihotri Supriya , Dhiman Priyanka 
Published: April 2024

Aim:
The purpose of the current study was to explore the virtual library for the
screening against Monoamine oxidase (MAO) isoforms. An in-house library of natural based
ligands was docked within the active sites of MAO isoforms and their in vitro study was also
conducted.

Objective:
The prime objective of the current study was to screen and validate the natural-based
derivatives for MAO inhibitory action with the least adverse effects and get molecular aspects
about further structural modifications on the most active leads.

Background:
The importance of MAOs in controlling the activity of the central nervous system
has been extensively studied. Our goal in this work is to identify a prospective natural lead molecule
that has a stronger affinity for the MAO enzyme in order to produce a more effective natural
candidate for a neurological agent.

Methods and Results:
In order to get insight into how different categories of natural compounds
interact with the targeted protein, we virtually screened the numerous natural compound categories
in the current study. Rhamnetin, quercetin, piperine, eugenol, and umbelliferone showed the
highest dock scores in the case of MAO-B, with scores of -10.57, -9.938, -9.445, and 7.821, respectively.
For MAO-A, umbelliferone, curcumin, caffeic acid, and quercetin, the corresponding
dock scores were -8.001, -7.941, -7.357, and -6.658. Additionally, an in vitro MAO inhibitory
experiment was utilized to assess the top-ranked compounds with the best docking scores.
The most potent Human Monoamine oxidase (hMAO-A) inhibitor, with an IC50 of 10.98±0.006
M and a selectivity index (SI) of 0.607, was discovered to be the compound umbelliferone.
Rhamnetin, the lead chemical, has demonstrated hMAO-B activity with a value of 10.32±0.044
M (SI value of 3.096).

Conclusion:
These natural potential ligands have been found remarkable to the standard compounds
against MAO-A and MAO-B, and they could be used as a lead chemical in the development
of novel therapeutic candidates. The in silico screening results and in vitro hMAO inhibitory
efficacy exhibited strong correlations.
TOUT EST « ETHIQUE » … MAIS C’EST UNE ETHIQUE A ETIQUETER ?
Authors: DANKOVA Klara 
Published: April 2024

Everything Is “Ethical” ... but Do We Label Ethics? During the 20th century, science and technology have developed remarkably, improving the quality of life for many people. However, this development, characterised by the excessive exploitation of natural and human resources, has also had negative consequences. In the 21st century, the spread of alarming news has prompted reflection on the ethical standards to be adopted in different areas of human activity, leading to the development of new practices as well as new terminology. These considerations bring us to the quest for the meaning of « éthique » in today’s time. The aim of this study is to examine the meaning of the adjective « éthique », which is often used to describe new concepts in this context. The analysis, carried out on a sample of N + éthique combinations extracted from the French Web 2020 corpus (frTenTen20) revealed that the meanings of « éthique » depend largely on the specialised field concerned. In some cases, the adjective can also be used to emphasise the absence of dishonest practices or with the intention of concealing the nature of an activity whose basic principles are often contested.
Totul este "etic"... dar este etic să etichetezi? De-a lungul secolului XX, știința și tehnologia s-au dezvoltat în mod remarcabil, făcând posibilă ameliorarea calității vieții unui mare număr de persoane. Cu toate acestea, această dezvoltare, marcată de exploatarea masivă a resurselor naturale și umane, a avut și consecințe negative. Astfel, în secolul XXI, răspândirea unor informații alarmante a stârnit o reflecție asupra criteriilor etice care trebuie să fie adoptate în diferitele domenii ale activității umane, ceea ce a dus la dezvoltarea unor noi practici și a unei noi terminologii. Aceste considerente ne împing să ne întrebăm ce înseamnă astăzi "etica". Finalitatea acestui studiu este aceea de a analiza semnificația adjectivului "etic", utilizat adesea pentru a desemna noi concepte în acest context. Analiza, efectuată pe un eșantion de combinații N + etică extrase din corpus-ul francez Web 2020 (frTenTen20), a demonstrat că semnificația termenului "etică" depinde, în mare măsură, de domeniul de specialitate vizat. În unele cazuri, adjectivul "etic" poate fi utilizat și pentru a pune în evidență absența practicilor incorecte sau cu intenția de a ascunde natura unei activități ale cărei principii de bază sunt deseori contestate.
Cuvinte-cheie: limbaj de specialitate, terminologie, neologism, etică, limba franceză
Article history: Received 14 September 2023; Revised 15 December 2023; Accepted 31 January 2024; Available online 27 March 2024; Available print 27 March 2024
Decoding the Magic Formula: Navigating the Complex World of Stock Trading
Authors: Wicaksono Soetam Rizky , Setiawan Rudy 
Published: April 2024

Stock trading is complicated and risky. Investors' conditions, aspirations, and viewpoints shape their journeys. This article examines stock trading and investing, focusing on Joel Greenblatt's "The Little Book That Beats the Market" and "Magic Formula" investment technique. Greenblatt's book argues that stock trading is better than saving. The "Magic Formula" focuses on return on capital and earnings yield and is simple but effective. The Magic Formula helps investors find cheap, high-quality firms by evaluating them by these two ratios. The Magic Formula, like every investment approach, has limitations. Its success depends on the investor's goals, risk tolerance, and situation. The Magic Formula works for some investors but not others. This emphasizes the need of personalizing one's financial approach and knowing that one size does not fit all. Greenblatt also stresses the significance of knowing and believing in the Magic Formula, even when it seems to be failing. He believes that effective investing requires both picking the correct companies and sticking to your strategy, even when it's hard. This emphasizes the significance of patience and discipline in investing, which are often neglected but essential for long-term success. The Magic Formula is one of several investment techniques and theories, each with its own assumptions, methods, and risk profiles. From buy-and-hold to complicated quantitative models, these methods cover it all. Investors' goals, risk tolerance, and circumstances should determine their strategy. In conclusion, stock trading demands cautious navigation and intelligent decision-making. Joel Greenblatt's Magic Formula helps guide investors. Its effectiveness depends on the investor and is not a one-size-fits-all solution. Thus, each individual must establish their own stock trading success route with the correct knowledge, method, and mindset.