bluuebunny/crossref_metadata_2025_split huggingface dataset:
JustiLM: Few-shot Justification Generation for Explainable Fact-Checking of Real-world Claims
Authors: Zeng Fengzhu , Gao Wei 
Published: April 2024

Abstract
Justification is an explanation that supports the veracity assigned to a claim in fact-checking. However, the task of justification generation has been previously oversimplified as summarization of a fact-check article authored by fact-checkers. Therefore, we propose a realistic approach to generate justification based on retrieved evidence. We present a new benchmark dataset called ExClaim (for Explainable fact-checking of real-world Claims), and introduce JustiLM, a novel few-shot Justification generation based on retrieval-augmented Language Model by using fact-check articles as an auxiliary resource during training only. Experiments show that JustiLM achieves promising performance in justification generation compared to strong baselines, and can also enhance veracity classification with a straightforward extension.1
Code and dataset are released at https://github.com/znhy1024/JustiLM.
The Middle Belt Factor in the Nigeria-Biafra War, 1967–1975
Authors: Eze Okonkwo Christopher , Ugbudian Lucky Igohosa , Alaku Emmanuel C 
Published: April 2024

Abstract
The Middle Belt factor in the Nigeria-Biafra War is a new perspective in Nigerian historical scholarship. The intra-elite competition for power in the Middle Belt resulted in the Tiv revolts of the early 1960s which eroded the legitimacy of Nigeria’s post-independence government. This study is a knowledge-building effort to analyse how the pendulum of the Middle Belt politics from 1967–1975 factored the Zone’s participation in the Nigeria-Biafra War, its influence in the war-time policies, as well as the post-war policies. The thrust of this study, therefore, is to demonstrate how the Middle Belt politics shaped the success of the war and the formulation of war policies during, and after the war in Nigeria. The argument from this perspective is that the crises in the Zone precipitated the coup and subsequent events that snowballed into the war, and their cumulative contributions to the end of the war.
Post-stroke depression, activities of daily living, and occupational therapy intervention: An observational survey
Authors: Anello Sara , Pisaniello Diletta Maria , Battain Pier Carlo 
Published: April 2024

Introduction: Post-stroke depression is a frequent but under-diagnosed condition. Nevertheless, it impacts participation in activities of daily living (ADLs) and the rehabilitation process. The aim of this study is to analyze the influence of post-stroke depression on participation in ADLs and on occupational therapy (OT) intervention in adults. Methods: An observational study was conducted through a survey. The questionnaire covered OTs view about the influence of post-stroke depression on ADLs and occupational therapy treatment. Data collected by online questionnaire were analyzed through STATA®, using a mixed method. Quantitative data were analyzed through descriptive statistics. Qualitative data were analyzed by thematic analysis. Results: Sixty-three surveys were valid. Stroke adults manifest hopelessness toward the future, crying and nervousness (“often” / “always” >50%). They have often worse occupational performance than patients with stable mood (55.56%), especially in self-care activities (35.92%). The performance limiting factors are low volition (41%), reduced motor skills (30%), and reduced cognitive skills (19%). OT intervention with these patients aims to increase volition (21.30%), recover roles (16.61%), and improve self-care activities (14.08%). Conclusion: Mood disorders negatively affect participation in ADLs and OT intervention. This study highlights the importance of volitional factors in promoting occupational engagement and provides guidance for OT treatment. Further investigation through specific studies appears necessary.
A Comparison of Post-Operative Patient Reported Outcome Measurements Following Bunion Surgery: Modified Lapidus vs Minimally Invasive Techniques
Authors: Bhend Madeline , Gauthier Chase , Gonzalez Tyler , Jackson J. Benjamin 
Published: April 2024

Introduction/Purpose: The modified Lapidus procedure (MLP) or a minimally invasive surgery distal transverse osteotomy (MISDTO) are acceptable surgical treatment options for hallux valgus. The current literature is evolving when comparing the effects of each procedure on patient reported outcomes and post-operative complications. The purpose of this study is to compare postoperative outcomes, time to weight bear, and patient reported outcomes using the Patient Reported Outcome Instrumentation System (PROMIS) for the MLP and MISDTO. Methods: This study retrospectively reviewed patients who underwent a MLP or MISDTO for hallux valgus correction at Prisma Health Midlands between February 2020 – February 2022. Data collected included: demographic data, postoperative outcomes, time to weight bear, and PROMIS scores, including Pain Interference (PI), Physical Function (PF), and Mobility scores. Paired Student’s T-Test and Wilcoxon Rank Sum test were used to compare continuous variables and Chi-Squared test for categorical variables. Results: A total of 81 patients undergoing MLP and 78 undergoing MISDTO were included in the study. Average follow-up for MLP and MISDTO patients was 53.7 and 43.4 weeks, respectively. MLP demonstrated significant improvement in PI (52.5 vs 56.8, P< 0.001) and Mobility (46.3 vs 43.4, P=0.044) scores, while MISDTO demonstrated a significant improvement in PI (48.8 vs 57.1, P< 0.001), PF (50.2 vs 44.9, P< 0.001), and Mobility (49 vs 42.8, P< 0.001) scores. MISDTO patients had significantly larger improvements in PI (7.6 vs 4.5, P=0.008), PF (5.3 vs 2.2, P=0.026), and Mobility (5.5 vs 2.9, P=0.02) compared to MLP patients. MISDTO patients had a significantly lower non-union rate (13.6% vs 2.6%, P=0.025), hardware failure rate (0% vs 9.9%, P=0.007), and time to weight-bear (2.2 vs 7.8 weeks, P< 0.001). Conclusion: Both MLP and MISDTO procedures are effective treatments for improving the pain and mobility issues associated with hallux valgus while maintaining patients’ function. MISDTO was found to improve patient reported outcomes significantly more than MLP, with a lower non-union rate, lower hardware failure rate, and shorter time to weight-bear. These findings suggest MISDTO is superior to MLP in improving patient reported outcomes and postoperative outcomes in the treatment of hallux valgus. Further study multicenter and long term outcome studies could be useful further evaluate these short term findings.
A Prospective Evaluation of a 3D-Printed 4th-Generation Total Ankle Prosthesis with 1-Year Follow- Up
Authors: Gross Christopher E. , Scott Daniel , Friscia David A. , Ellis Scott J. , Owens Richard F. 
Published: April 2024

Introduction/Purpose: Fixation of fourth-generation ankle replacements is evolving. Given the concern for tibial tray loosening or radiolucencies, three-dimensional (3-D) printing has been suggested as a solution. Additive manufacturing allows for the creation of an optimal implant surface for improved initial stability and bony on growth. To date, there are no reported data concerning survivorship and clinical improvement following a 3-D printed ankle replacement. Documentation of implant survivability and comparison studies of the latest generation implants are limited. The purpose of this study is report on prospectively-collected patient reported outcome measures (PROMs) in a multi-institutional study of a 3-D printed fourth-generation total ankle. Methods: Patients presenting for a total ankle replacement at 12 institutions were prospectively enrolled and implanted in both academic and private settings. Patients had demographics and PROMs recorded pre-operatively and at 6 month and 12-month intervals. The following PROMs were collected: Ankle Osteoarthritis Score (AOS), PROMIS Global Physical Health, Foot and Ankle Outcome Score (FAOS), and satisfaction scores. The preoperative and latest follow-up scores for patients with two years of follow-up were analyzed. Results: 91 of 177 subjects enrolled have reached one-year in follow-up currently. From the 177 enrolled (52.5% male) with an average age of 64.0±10.3 years old with an average BMI of 30.8±6.2. The pre-operative diagnosis for arthritis type was degenerative arthritis (27.7%), rheumatoid arthritis (1.7), post-traumatic arthritis (70.1%), and other (0.50%). There were 3 (1.69%) clinical failures:1 early infection: at 2 months, 1 tibial subsidence at 7 months, and 1 deep infection associated with trauma at 8 months post-operatively. The patients improved in all PROMs domains at one year including: Mean Total AOS (19.0. ± 17.5) p<.0001); PROMIS Global Physical Health (49.6 ± 17.1 p<.0001); Total FAOS Symptom Scores at 1 year (75.0 ± 19.5, p<.0001). The Total FAOS QOL at 1 year is 65.3 ± 25.2. Conclusion: At one-year post-implantation follow-up, the fourth generation 3D printed total ankle replacement had a low revision rate and proved to be safe and effective compared to historical ankle replacement outcomes. Patients were overwhelmingly satisfied and had statistically significant clinical improvements in each domain of their PROMs.
"I Can’t Exercise Because My Foot Hurts Me Too Much." Does BMI Change after Common Foot and Ankle Surgeries? A Retrospective Review
Authors: Weiss Samantha N. , Higgins Margaret , McKeeman Jonathan , Lachman James R. 
Published: April 2024

Introduction/Purpose: The World Health Organization reports that 1.9 billion people worldwide have a body mass index (BMI) that classifies them as being either overweight (BMI > 25) or obese (BMI > 30). Patients often claim, prior to orthopaedic surgery, that their physical activity and exercise is negatively impacted by their orthopaedic condition. Hip and Knee arthroplasty literature has established that patients with high preoperative BMI continue to have high BMI post-operatively, despite also reporting improvements in their joint pain. No such studies exist in foot and ankle surgery. The purpose of this study was to analyze changes in BMI after many common foot and ankle surgeries. Methods: A retrospective review of all patients undergoing bunion correction, flatfoot correction, 1st MTP arthrodesis, and midfoot arthrodesis procedures between November 2018 and December 2022 was conducted in this IRB approved, single center study. BMI data was collected from the electronic medical record for preoperative and 12 months postoperative time points. Descriptive statistics were reported for age, gender, diabetes, A1c for diabetic patients, smoking status, and overall follow up time. Repeated measures of analysis of variation were conducted with one between-groups factor being type of surgery. Results: 196 patients were included in the study. The average age was 62.1 years, 151(76.6%) patients were female. Average BMI amongst all patients preoperatively was 29.58 +/- 5.21, and postoperatively 29.79 +/- 5.33, with an overall average increase in BMI of 0.2182 +/- 2.21. Upon subgroup analysis, all surgical cohorts yielded an increase in postoperative BMI (bunion +0.2489 +/- 2.06, double arthrodesis +0.4767 +/- 1.37, 1st MTP fusion +0.2293 +/- 2.07, midfoot arthrodesis +0.0251 +/- 3.10) although these changes did not reach significance (p value 0.425). There was no significant difference observed in changes in BMI between surgical groups (p value 0.958). BMI outcomes were normally distributed with acceptable equality of error variances (Levene’s test p- values > 0.270). Conclusion: The current statistics surrounding the prevalence of overweight and obesity are staggering. The results of this study demonstrate that elective orthopaedic surgery of common foot and ankle procedures do not facilitate a change in BMI one year postoperatively, despite the goal of reducing chronic pain and increasing physical function, which is often cited as the primary restriction to exercise amongst patient populations. Additional studies are warranted to further elucidate changes in BMI to adequately council patients regarding postoperative expectations. Study Data Summary
Spatial Distribution and Characteristics of Protein Content and Composition in Japonica Rice Grains: Implications for Sake Quality
Authors: Takahashi Kei , Kohno Hiromi , Okuda Masaki 
Published: April 2024

AbstractThe quantity and composition of rice proteins play a crucial role in determining taste quality ofsake, Japanese rice wine. However, the spatial distribution of proteins within rice grains, especially in endosperm tissue, and the differences between rice varieties remain unclear. Here, we analyzed the crude protein contents and composition ratios of table (NipponbareandKoshihikari) and genuine sake rice varieties (Yamadanishiki,Gohyakumangoku,Dewasansan,Dewanosato, andYumenokaori) to elucidate their spatial distribution within the Japonica rice grain endosperm. Seven sake rice varieties were polished over five harvest years using a brewer’s rice-polishing machine. We obtained fractions at 90–70% (the outermost endosperm fraction), 70–50%, 50–30%, and 30–0% (the central region of the endosperm fraction).YamadanishikiandDewanosatoexhibited considerably lower crude protein contents than the other cultivars. After applying SDS-PAGE, the protein composition, comprising glutelin/total protein (G/TP), prolamin/TP (P/TP), and G/P ratios of these fractions was determined. In white rice (at a 90% rice-polishing ratio), the average ratio of the major protein composition was G/TP 41%, P/TP 21%, and G/P ratios of 1.97.GohyakumangokuandYamadanishikihad higher G/TP ratio, whileDewanosatohad a lower value. Despite having lower crude protein contents,YamadanishikiandDewanosatoexhibited significantly varying G/TP ratios. The G/TP ratio markedly varied among rice varieties, particularly in the rice grains’ central region. The 50–30% fraction had the highest P/TP ratio among all tested rice varieties, suggesting spatial differences in P/TP within rice grains.Koshihikarihad the lowest P/TP ratio. In addition, the 50–30% fraction had the lowest G/P ratio among all tested rice varieties, withGohyakumangokuhaving the highest G/P ratio.Dewanosatohad the lowest G/P value, and this value significantly differed from that ofYamadanishikiin the 30–0% fraction. We found substantial differences in protein composition within distinct spatial regions of rice grains, and larger differences among rice varieties were observed in the rice grain’s central region.
MultiToxPred 1.0: a novel comprehensive tool for predicting 27 classes of protein toxins using an ensemble machine learning approach
Authors: Beltrán Jorge F. , Herrera-Belén Lisandra , Parraguez-Contreras Fernanda , Farías Jorge G. , Machuca-Sepúlveda Jorge , Short Stefania 
Published: April 2024

AbstractProtein toxins are defense mechanisms and adaptations found in various organisms and microorganisms, and their use in scientific research as therapeutic candidates is gaining relevance due to their effectiveness and specificity against cellular targets. However, discovering these toxins is time-consuming and expensive. In silico tools, particularly those based on machine learning and deep learning, have emerged as valuable resources to address this challenge. Existing tools primarily focus on binary classification, determining whether a protein is a toxin or not, and occasionally identifying specific types of toxins. For the first time, we propose a novel approach capable of classifying protein toxins into 27 distinct categories based on their mode of action within cells. To accomplish this, we assessed multiple machine learning techniques and found that an ensemble model incorporating the Light Gradient Boosting Machine and Quadratic Discriminant Analysis algorithms exhibited the best performance. During the tenfold cross-validation on the training dataset, our model exhibited notable metrics: 0.840 accuracy, 0.827 F1 score, 0.836 precision, 0.840 sensitivity, and 0.989 AUC. In the testing stage, using an independent dataset, the model achieved 0.846 accuracy, 0.838 F1 score, 0.847 precision, 0.849 sensitivity, and 0.991 AUC. These results present a powerful next-generation tool called MultiToxPred 1.0, accessible through a web application. We believe that MultiToxPred 1.0 has the potential to become an indispensable resource for researchers, facilitating the efficient identification of protein toxins. By leveraging this tool, scientists can accelerate their search for these toxins and advance their understanding of their therapeutic potential.
Split Pool Ligation-based Single-cell Transcriptome sequencing (SPLiT-seq) data processing pipeline comparison
Authors: Kuijpers Lucas , Hornung Bastian , van den Hout - van Vroonhoven Mirjam C. G. N. , van IJcken Wilfred F. J. , Grosveld Frank , Mulugeta Eskeatnaf 
Published: April 2024

Abstract
Background
Single-cell sequencing techniques are revolutionizing every field of biology by providing the ability to measure the abundance of biological molecules at a single-cell resolution. Although single-cell sequencing approaches have been developed for several molecular modalities, single-cell transcriptome sequencing is the most prevalent and widely applied technique. SPLiT-seq (split-pool ligation-based transcriptome sequencing) is one of these single-cell transcriptome techniques that applies a unique combinatorial-barcoding approach by splitting and pooling cells into multi-well plates containing barcodes. This unique approach required the development of dedicated computational tools to preprocess the data and extract the count matrices. Here we compare eight bioinformatic pipelines (alevin-fry splitp, LR-splitpipe, SCSit, splitpipe, splitpipeline, SPLiTseq-demultiplex, STARsolo and zUMI) that have been developed to process SPLiT-seq data. We provide an overview of the tools, their computational performance, functionality and impact on downstream processing of the single-cell data, which vary greatly depending on the tool used.

Results
We show that STARsolo, splitpipe and alevin-fry splitp can all handle large amount of data within reasonable time. In contrast, the other five pipelines are slow when handling large datasets. When using smaller dataset, cell barcode results are similar with the exception of SPLiTseq-demultiplex and splitpipeline. LR-splitpipe that is originally designed for processing long-read sequencing data is the slowest of all pipelines. Alevin-fry produced different down-stream results that are difficult to interpret. STARsolo functions nearly identical to splitpipe and produce results that are highly similar to each other. However, STARsolo lacks the function to collapse random hexamer reads for which some additional coding is required.

Conclusion
Our comprehensive comparative analysis aids users in selecting the most suitable analysis tool for efficient SPLiT-seq data processing, while also detailing the specific prerequisites for each of these pipelines. From the available pipelines, we recommend splitpipe or STARSolo for SPLiT-seq data analysis.
Changes in temperature in preheated crystalloids at ambient temperatures relevant to a prehospital setting: an experimental simulation study with the application of prehospital treatment of trauma patients suffering from accidental hypothermia
Authors: Jensen Emil , Rentzhog Helena , Herlitz Johan , Axelsson Christer , Lundgren Peter 
Published: April 2024

Abstract
Background
Accidental hypothermia is common in all trauma patients and contributes to the lethal diamond, increasing both morbidity and mortality. In hypotensive shock, fluid resuscitation is recommended using fluids with a temperature of 37–42°, as fluid temperature can decrease the patient’s body temperature. In Sweden, virtually all prehospital services use preheated fluids. The aim of the present study was to investigate how the temperature of preheated infusion fluids is affected by the ambient temperatures and flow rates relevant for prehospital emergency care.

Methods
In this experimental simulation study, temperature changes in crystalloids preheated to 39 °C were evaluated. The fluid temperature changes were measured both in the infusion bag and at the patient end of the infusion system. Measurements were conducted in conditions relevant to prehospital emergency care, with ambient temperatures varying between − 4 and 28 °C and flow rates of 1000 ml/h and 6000 ml/h, through an uninsulated infusion set at a length of 175 cm.

Results
The flow rate and ambient temperature affected the temperature in the infusion fluid both in the infusion bag and at the patient end of the system. A lower ambient temperature and lower flow rate were both associated with a greater temperature loss in the infusion fluid.

Conclusion
This study shows that both a high infusion rate and a high ambient temperature are needed if an infusion fluid preheated to 39 °C is to remain above 37 °C when it reaches the patient using a 175-cm-long uninsulated infusion set. It is apparent that the lower the ambient temperature, the higher the flow rate needs to be to limit temperature loss of the fluid.
Successful therapy with tenofovir disoproxil fumarate (TDF) in patients with chronic hepatitis B (CHB) does not guarantee amelioration of liver damage assessing by transient elastography. A retrospective - prospective multicenter study
Authors: Kranidioti Hariklia , Zisimopoulos Konstantinos , Oikonomou Theodora , Voulgaris Theodoros , Siakavellas Spyros , Agorastou Polixeni , Deutsch Melanie , Triantos Christos , Goulis Ioannis , Papatheodoridis George , Manolakopoulos Spilios 
Published: April 2024

Abstract
Background
Preventing disease progression and viral suppression are the main goals of antiviral therapy in chronic hepatitis B (CHB). Liver stiffness measurement (LSM) by transient elastography is a reliable non-invasive method to assess liver fibrosis in patients with CHB. Our aim was to explore factors that may affect changes in LSMs during long term tenofovir (TDF) monotherapy in a well characterized cohort of patients with compensated CHB.

Methods
We analyzed serial LSMs in 103 adult patients with CHB who were on TDF monotherapy and had at least three LSMs over a period of 90 months.

Results
Twenty-five (24%) patients had advanced fibrosis at baseline. A significant decline in mean LSM between baseline and last visit (8.7 ± 6.2 kPa vs. 6.7 ± 3.3, p = 10− 3) was observed. Twenty-four (23%) patients had progression of liver fibrosis with mean increase in liver stiffness of 2.8 kPa (range: 0.2–10.2 kPa). Multivariate analysis showed that BMI ≥ 25 (OR, 0.014; 95% CI, 0.001–0.157; p = 0.001) and advanced fibrosis (OR, 5.169; 95% CI, 1.240–21.540; p = 0.024) were independently associated with a fibrosis regression of > 30% of liver stiffness compared to baseline value.

Conclusions
In CHB patients TDF monotherapy resulted in liver fibrosis regression, especially in patients with advanced fibrosis. Despite the successful antiviral effect of TDF, 1 out of 4 patients had liver fibrosis progression. Obesity and advanced fibrosis at baseline were independently associated with significant liver fibrosis regression.