bluuebunny/crossref_metadata_2025_split huggingface dataset:
SEEKING FOR OPTIMISM IN â€œSANG PEMIMPIâ€ NOVEL :A CRITICAL BOOK REVIEW
Authors: Chairunnisa Suci , Sari Risma , Gultom Kristina 
Published: March 2024

Novel Sang Pemimpi (NSP) is the second novel written by Andrea Hirata from the Laskar Pelangi tetralogy. This research focuses to explore and understand the values of optimism in NSP using a psychological approach, based on 6 characteristics of optimism in Daniel Goleman book (1995) â€œEmotional Intelligence.â€Â Â The characteristics of optimism include: having high expectations, not easily discouraged, being able to motivate themselves, having high self-confidence, not being resigned, and seeing something as a thing that can be changed. This study found that all 6 characteristics of optimismÂ Â in NSPÂ Â using the content analysis method In a descriptive qualitative approach based on the principles designed by Meleong (2005), this study sees that this novel teaches the importance of having a dream and a strong effort to realize that dream even in a state of complete limitationsÂ
A Review of Charanjit Kaur Swaran Singh: The Mistake of Writing in Grammar Errors
Authors: Putri Wella C. , Hadita Almira , Simanullang Jessica P. , Hasanah Aprilia 
Published: March 2024

This paper aimed at reviewing the article entitled â€œThe Mistake of Writing In Grammar Errors Made by Studentsâ€ written by Charanjit Kaur Swaran Singh, et.all., (2019). It seems in this article the ignored skill is â€œwritingâ€ skill. She mentioned as a skill that most underestimated in the ESL context. The aims this study is to analyze the difficulties of grammar error committed by ESL studies in writing comprehend faced by students of Senior Lecture on department Faculty of Language and Communication Universiti.Â The errors of theÂ research findings revealed that subject-verb agreement and tenses were the most common type of errors. involving aroundgroup of Diploma students who sat for a university entrance exam.Â Interview and a set of questions was accumulated from data.Â In addition, the students are not having the skill to understood the meanings of nine types of grammatical. Moreover, the students are not able to understanding essay in writing their are have poor command of the English language. The paper sees this articles are trying to detect the ESL studentsâ€™weakness in writing. These results may help ESL teachers and boosting students writing comprehension skills. As a outcome, this present paper may say that this article can be replicable onto the same topic research, especially on the methodology section.Â Â
Perbaikan Sifat Kimia Tanah dengan Penanaman Asystasia gangetica (L.) T. Anderson sebagai Cover Crop
Authors: Asbur Yenni 
Published: March 2024

This decrease in land productivity is closely related to the reduced organic matter content in the soil, so efforts are needed to overcome it by utilizing asystasia gangetica weeds as a cover crop. The purpose of this study was to determine the benefits of A. gangetica as a cover crop in improving soil chemical properties under shaded and unshaded conditions. The research was conducted at the Experimental Garden of the Faculty of Agriculture, Islamic University of North Sumatra (UISU), Johor Building, Medan. The research method used was a split plot design in a factorial randomized block design. The first factor as the main plot is Shade (N) and the second factor as the subplot is Cover crop (C) with three replications. The results of this study showed that A. gangetica grown as a cover crop was able to improve soil chemical properties by increasing the organic C, total N, and available K content of the soil after treatment. Likewise, the combination of both shaded and unshaded treatments with cover crop A. gangetica (N1C1 and N0C1) was able to improve soil chemical properties by increasing the C-organic, total N, and available K-content of the soil after treatment.
POTENSI EKOWISATA DANAU UTER DI DISTRIK AITINYO KABUPATEN MAYBRAT-PAPUA BARAT DAYA
Authors: Fatem Sepus , Marwa Jonni , Bosawer Marlin 
Published: March 2024

Penelitian dilakukan di Danau Uter Distrik Aitinyo Kabupaten Maybrat. Tujuan penelitian ini adalah 1) mengetahui keberadaan obyek daya tarik wisata (ODTW) Danau Uter sebagai potensi ekowisata untuk mendukung perekonomian masyarakat, 2) kondisi sosial budaya masyarakat dan pemerintah dalam mendukung pengembangan ekowisata dan 3) mengkaji faktor-faktor yang mempengaruhi pengembangan ekowisata.. Metode yang digunakan adalah deskriptif dan teknik studi kasus. Variabel pengamatan meliputi keberadaan sumberdaya alam sebagai ODTW, sosial budaya masyarakat, aksesibilitas, akomodasi, sarana prasarana dan dukungan pemerintah daerah. Studi ini menunjukan bahwa Danau Uter berpotensi untuk dikembangkan sebagai obyek daya tarik wisata yang didukung oleh panorama yang indah, situs bersejarah, keanekaragaman flora dan fauna, kondisi sosial budaya masyarakat lokal dan infrastruktur pendukung. Disisi lain kapasitas pemerintah daerah sangat diharapkan oleh masyarakat dalam pengembangan ODTW Danau Uter.
Analisis dan Proyeksi Kebutuhan Beberapa Komoditas Tanaman Pangan menggunakan Pendekatan Sistem Dinamis untuk Memenuhi Kebutuhan Pangan di Kabupaten Manokwari
Authors: Faisol Arif , Rahmawati Siti Asfihana , Hutasoit Hostalige 
Published: March 2024

Pangan merupakan salah satu aspek dasar yang harus dipenuhi bagi seluruh penduduk Indonesia. Neraca Bahan Makanan (NBM) merupakan salah satu alat yang digunakan untuk menggambarkan situasi pangan suatu wilayah. Penelitian ini bertujuan untuk menganalisis serta memproyeksikan kebutuhan beberapa komoditas tanaman pangan di Kabupaten Manokwari menggunakan sistem dinamis, yaitu padi, kedelai, jagung, kacang tanah, kacang hijau, ubi kayu, dan ubi jalar. Secara umum penelitian ini terdiri atas 4 (empat) tahapan utama, yaitu; inventarisasi data, analisis data, penyusunan model, dan proyeksi kebutuhan beberapa komoditas tanaman pangan sampai tahun 2050. Hasil penelitian menunjukkan bahwa pada tahun 2022 sejumlah tanaman pangan mengalami defisit, diantaranya padi, kedelai, dan kacang hijau. Sedangkan tanaman jagung, kacang tanah, ubi kayu, dan ubi jalar mengalami surplus. Salah satu upaya yang dapat dilakukan agar kebutuhan pangan di Kabupaten Manokwari dapat tercukupi hingga tahun 2050 adalah peningkatan produksi tanaman pangan melalui perluasan lahan tanaman pangan dan penggunaan varietas unggul. Disamping itu peningkatan Indeks Pertanaman (IP) tanaman padi dari 2 kali setahun menjadi 3 kali setahun merupakan solusi alternatif yang dapat digunakan untuk meningkatkan produksi padi akibat terbatasnya lahan pertanian yang disediakan oleh pemerintah.
Pemberdayaan Masyarakat dalam Pengembangan ekosistem wilayah pesisir Pantai Malaumkarta Kabupaten Sorong
Authors: Mardliyah Uswatul , Purwanti Nanik , Nikmatul Ula Siti Nurul , Masniar Masniar 
Published: March 2024

Pemberdayaan masyarakat dalam pengembangan ekosistem wilayah pesisir pantai Malaumkarta Distrik Makbon Kabupaten Sorong melalui kegiatan pengabdian kepada masyarakat menunjukkan masyarakat di kampung malaumkarta belum terlalu memahami manfaat dan juga peluang mengembangkan ekosistem wilayah pesisir pantai yang merupakan salah satu objek pariwisata, dan tentu ini berpengaruh pada kondisi perekonomian masyarakatnya yang masih sangat rendah. Metode yang digunakan adalah ceramah dan diskusi. pengabdian kepada masyarakat ini merupakan bagian dari tri dharma perguruan tinggi sebagai implementasi ilmu pengetahuan yang bertujuan meningkatkan kemampuan masyarakat dalam hal ini bagaimana memberdayakan masyarakat dalam pengembangan ekosistem wilayah pesisir pantai.
Talkshow Gen Z Undercover: Memahami Dunia dari Sisi Remaja di Madrasah Aliyah (MA) Darussalam Barandasi Kab. Maros
Authors: Suryaningsih Ita , Kasmawati  , Aryanti  , Ince Nasrullah  , Nurhikmah Amalia  , Muh. Kiswa  
Published: March 2024

Masa remaja merupakan masa transisi dari masa anak-anak menuju masa dewasa. Satu tahapan perkembangan manusia yang cukup penting dalam membentuk identitas diri, pembentukan nilai-nilai baru menuju pribadi yang matang. Identifikasi dan imitasi role model yang disenangi adalah salah satu cara yang dilakukan remaja dalam membentuk nilai-nilai tersebut. Dalam proses pencarian jati diri tersebut ada banyak permasalahan yang dihadapi oleh remaja. Permasalahan pada remaja sangat beragam dan lingkungan sangat berpengaruh dalam ini. Faktor teman sebaya merupakan salah satu faktor yang memiliki pengaruh besar terhadap kecenderungan remaja melakukan kenakalan. Di masa ini, remaja memilih teman sesuai dengan jenis kelamin, kegemaran, minat atau perasaan senasib. Pihak sekolah telah melakukan banyak hal dalam meminimalisir tindakan-tindakan siswa nya yang mengarah pada kenakalan remaja. Talkshow genZ: memahami dunia dari sisi remaja merupakan kegiatan tim pengabdian untuk siswa-siswi di MA Darussalam Barandasi Kab. Maros. Kegiatan talkshow adalah salah satu program pengabdian kepada masyarakat yang dilaksanakan oleh tim mahasiswa Kemahiran Mengajar Aplikasi Lapangan (KEMAL) Universitas Muslim Maros. Tujuan dari kegiatan ini difokuskan pada (a) Pengenalan dunia remaja generasi Z; (b) Memberikan gambaran tahapan perkembangan pada remaja; (c) Memotivasi remaja generasi Z untuk mengembangkan diri sesuai dengan perkembangan jaman mereka yang serba digital. Metode yang digunakan adalah melalui talkshow agar lebih interaktif antara peserta dan narasumber. Peserta talkshow terdiri dari anggotas Organisasi Siswa Sekolah (OSIS) dan perwakilan masing-masing kelas. Hasil kegiatan menunjukkan peserta sangat antusias dengan penyajian materi yang diberikan. Hal tersebut ditunjukkan dengan beberapa pertanyaan yang diajukan kepada narasumber. Pihak sekolah dalam hal ini kepala MA Darussalam Barandasi sangat menerima dengan baik kegiatan pengabdian ini.
Objective sleep characteristics and hypertension: a community-based cohort study
Authors: Chen Chunyong , Zhang Bo , Huang Jingjing 
Published: March 2024

ObjectiveThe link between sleep quality and hypertension risk is well-established. However, research on the specific dose-relationship between objective sleep characteristics and hypertension incidence remains limited. This study aims to explore the dose-relationship association between objective sleep characteristics and hypertension incidence.MethodsA community-based prospective cohort study design was employed using data from the Sleep Heart Health Study (SHHS). A total of 2,460 individuals were included in the study, of which 780 had hypertension. Baseline personal characteristics and medical history were collected. Objective sleep characteristics were obtained through polysomnography (PSG). Multivariate logistic regression models were utilized for analysis. Restricted cubic splines (RCS) were used to examine dose-relationship associations.ResultsAfter adjusting for covariates, the percentage of total sleep duration in stage 2 (N2%) was positively associated with hypertension incidence, while the N3% was negatively associated with hypertension incidence Odds ratio (OR) = 1.009, 95% confidence interval (CI) [1.001, 1.018], P = 0.037; OR = 0.987, 95% CI: [0.979, 0.995], P = 0.028, respectively. For every 10% increase in N2 sleep, the risk of developing hypertension increases by 9%, while a 3% decrease in N3 sleep corresponds to a 0.1% increase in the incidence of hypertension. In the subgroup of non-depression, a positive association between N2% and hypertension was significant statistically (OR = 1.012, 95%CI, 1.002, 1.021, P = 0.013, Pinteraction = 0.013). RCS demonstrated that the risk of developing hypertension was lower when N2% ranged from 38% to 58% and rapidly increased thereafter (P = 0.002, non-linear P = 0.040). The lowest risk for hypertension incidence risk of N3% occurring at 25%, and a significant increase below 15% or above 40% (P = 0.001, non-linear P = 0.008).ConclusionsThere's a negative association between N3% and the incidence of hypertension, and a positive association between N2% and the incidence of hypertension, particularly among non-depression individuals. These associations exhibit strong non-linear dose-response relationships.
The effect of β-cell dysfunction on reproductive outcomes of PCOS undergoing IVF or ICSI embryo transfer cycles: a retrospective cohort study
Authors: Huang Wenle , Liu Chang , Ding Lin , Li Yan , Zhou Haisu , Wang Shuwei , Yang Haiyan 
Published: March 2024

ObjectiveTo investigate the effects of β-cell dysfunction on IVF outcomes in women with PCOS.MethodsThis retrospective cohort study includes 1,212 women with PCOS undergoing their first IVF cycle between September 2010 and December 2019. Beta-cell dysfunction was measured by homeostasis model assessment of β-cell function (HOMA-β) index.ResultsIn quartiles of HOMA-β, the incidence of miscarriage dramatically increased from 10.2% (Q1) to 31.1% (Q4) (Pfor trend &lt;0.001). Likewise, the incidence of miscarriage in quartiles of HOMA-β also showed a similar trend (Pfor trend &lt;0.001). After adjusting for confounding factors, logistic regression analyses showed that high HOMA-IR values were independently associated with a high risk of miscarriage, with the odds ratios (OR) and 95% confidence intervals for quartiles 2–4 versus quartile 1 were 1.30 (0.69-2.46), 1.82 (0.97-3.43), and 3.57 (1.86-6.85), respectively (Pfor trend &lt;0.001). When analyzed jointly, women in the highest HOMA-IR and highest HOMA-β group exhibited the highest risk for miscarriage compared with all other groups. Furthermore, higher HOMA-IR values were associated with higher risks of miscarriage among PCOS women regardless of HOMA-β values.Conclusionsβ-cell dysfunction is independently associated with increased miscarriage rate and decreased live birth rate in women with PCOS. It also plays a synergistic role with IR in terms of the reproductive outcomes, while the influence of IR overweighs that of β-cell dysfunction.
Drivers of CO2-carbonate system variability in the coastal ocean south of Honolulu, Hawai’i
Authors: Knor Lucie A. C. M. , Meléndez Melissa , Sabine Christopher L. , Sutton Adrienne J. 
Published: March 2024

This study examines carbonate chemistry variability from 2008 to 2021 in subtropical coastal waters adjacent to Honolulu, Hawai’i. We use surface seawater carbon dioxide partial pressure (pCO2sw) measurements obtained every three hours from two buoys located along the south shore of O’ahu near anthropogenically impacted fringing reefs. The Ala Wai buoy was located 200 m offshore of a canal draining most of Honolulu, while the Kilo Nalu buoy was 1.3 miles (2 km) to the northwest, at a similar distance from shore with fewer terrestrial inputs. We compare pCO2sw variability from diurnal to interannual time scales. A trend analysis reveals a statistically significant increase in pCO2sw of +1.84 ± 0.27 µatm per year over the 11-year period. This rate is slightly lower than the average atmospheric growth rate observed during the same timeframe. In contrast to a nearby open-ocean site, the coastal sites experience amplified shorter-term variability, while seasonal to inter-annual variability is comparable to the open ocean. Ala Wai exhibits greater ranges than Kilo Nalu in all carbonate system variables due to its proximity to the Ala Wai Canal outflow. We examine the drivers that may explain both the similarities and contrasts in carbon dynamics observed between the two locations. Drivers of aragonite saturation state (ΩAr), an important variable for quantifying ocean acidification, are isolated from the in-situ time-series. Interannual salinity variations both due to freshwater pulses and large-scale regional salinity changes have a larger impact on ΩAr than temperature changes, which mostly have an effect seasonally. A large biological contribution to ΩAr is suspected, and further investigated using TA/DIC ratios normalized to median salinity and their slopes. Observed ratios at the south shore sites are evaluated relative to expected ratios derived from an open-ocean reference. Results suggest that dissolution and respiration are the primary biogeochemical processes occurring at these coastal sites. This highlights the significance of carbonate dissolution in anthropogenically impacted coastal waters, which is likely buffering acidification due to anthropogenic CO2 and freshwater inputs at these sites.
The role of age in ocular toxoplasmosis: clinical signs of immunosenescence and inflammaging
Authors: Eraghi Armin Taghavi , Garweg Justus G. , Pleyer Uwe 
Published: March 2024

PurposeThis study aimed to investigate the association between age, immune response, and clinical presentation of ocular toxoplasmosis (OT).DesignThis was a monocentric, retrospective, observational cohort study.MethodsA review of the medical records of patients with active OT at the Uveitis Center, Charité Universitätsmedizin, was conducted. Baseline parameters included age at presentation, visual acuity, intraocular pressure (IOP), size and location of active lesions, inflammatory activity, antibody index (AI), and complications of intraocular inflammation. The data were presented as the mean ± standard deviation (SD). The level of significance was set at a p-value of &lt;0.05.ResultsBetween 1998 and 2019, 290 patients with active OT were diagnosed at our tertiary reference center. The mean age of the participants was 37.7 ± 17.1 years, 53.8% of them were female individuals, and 195 patients (70.9%) showed recurrent disease. Older age was associated with lower baseline visual acuity (p = 0.043), poor visual outcome (p = 0.019), increased inflammatory activity (p &lt; 0.005), and larger retinal lesions (p &lt; 0.005). Older patients presented a lower AI (&lt;35 years: 45.1 ± 82.7, median: 12.1; ≥35 years: 18.6 ± 50.5, median: 5.8; p = 0.046), confirmed by a decrease in AI with increasing age (R2 = 0.045; p = 0.024). Finally, AI was correlated with lesion size (multiple linear regression analysis: p = 0.043). Macular involvement (24.3% of patients) was positively correlated with complications (macular/peripapillary edema and retinal detachment, p &lt; 0.005) and poor visual outcome (p &lt; 0.005) and was negatively correlated with inflammatory activity (p &lt; 0.005).ConclusionWe found a strong and clinically relevant impact of age on the clinical presentation and course of OT. While an unspecific inflammatory response increased with age, the specific, local humoral immune response declined. These findings are well in line with the concept of immunosenescence and inflammaging in uveitis.
A phase I clinical trial assessing the safety, tolerability, and pharmacokinetics of inhaled ethanol in humans as a potential treatment for respiratory tract infections
Authors: Hancock David G. , Ditcham William , Ferguson Eleanor , Karpievitch Yuliya V. , Stick Stephen M. , Waterer Grant W. , Clements Barry S. 
Published: March 2024

BackgroundCurrent treatments for respiratory infections are severely limited. Ethanol’s unique properties including antimicrobial, immunomodulatory, and surfactant-like activity make it a promising candidate treatment for respiratory infections if it can be delivered safely to the airway by inhalation. Here, we explore the safety, tolerability, and pharmacokinetics of inhaled ethanol in a phase I clinical trial.MethodsThe study was conducted as a single-centre, open-label clinical trial in 18 healthy adult volunteers, six with no significant medical comorbidities, four with stable asthma, four with stable cystic fibrosis, and four active smokers. A dose-escalating design was used, with participants receiving three dosing cycles of 40, 60%, and then 80% ethanol v/v in water, 2 h apart, in a single visit. Ethanol was nebulised using a standard jet nebuliser, delivered through a novel closed-circuit reservoir system, and inhaled nasally for 10 min, then orally for 30 min. Safety assessments included adverse events and vital sign monitoring, blood alcohol concentrations, clinical examination, spirometry, electrocardiogram, and blood tests.ResultsNo serious adverse events were recorded. The maximum blood alcohol concentration observed was 0.011% immediately following 80% ethanol dosing. Breath alcohol concentrations were high (median 0.26%) following dosing suggesting high tissue levels were achieved. Small transient increases in heart rate, blood pressure, and blood neutrophil levels were observed, with these normalising after dosing, with no other significant safety concerns. Of 18 participants, 15 completed all dosing cycles with three not completing all cycles due to tolerability. The closed-circuit reservoir system significantly reduced fugitive aerosol loss during dosing.ConclusionThese data support the safety of inhaled ethanol at concentrations up to 80%, supporting its further investigation as a treatment for respiratory infections.Clinical trial registration: identifier ACTRN12621000067875.
Post-operative sepsis-induced acute respiratory distress syndrome: risk factors for a life-threatening complication
Authors: Bardají-Carrillo Miguel , Martín-Fernández Marta , López-Herrero Rocío , Priede-Vimbela Juan Manuel , Heredia-Rodríguez María , Gómez-Sánchez Esther , Gómez-Pesquera Estefanía , Lorenzo-López Mario , Jorge-Monjas Pablo , Poves-Álvarez Rodrigo , Villar Jesús , Tamayo Eduardo 
Published: March 2024

IntroductionPrevalence and mortality of the acute respiratory distress syndrome (ARDS) in intensive care units (ICU) are unacceptably high. There is scarce literature on post-operative sepsis-induced ARDS despite that sepsis and major surgery are conditions associated with ARDS. We aimed to examine the impact of post-operative sepsis-induced ARDS on 60-day mortality.MethodsWe performed a secondary analysis of a prospective observational study in 454 patients who underwent major surgery admitted into a single ICU. Patients were stratified in two groups depending on whether they met criteria for ARDS. Primary outcome was 60-day mortality of post-operative sepsis-induced ARDS. Secondary outcome measures were potential risk factors for post-operative sepsis-induced ARDS, and for 60-day mortality.ResultsHigher SOFA score (OR 1.1, 95% CI 1.0–1.3, p = 0.020) and higher lactate (OR 1.9, 95% CI 1.2–2.7, p = 0.004) at study inclusion were independently associated with ARDS. ARDS patients (n = 45) had higher ICU stay [14 (18) vs. 5 (11) days, p &lt; 0.001] and longer need for mechanical ventilation [6 (14) vs. 1 (5) days, p &lt; 0.001] than non-ARDS patients (n = 409). Sixty-day mortality was higher in ARDS patients (OR 2.7, 95% CI 1.1–6.3, p = 0.024). Chronic renal failure (OR 4.0, 95% CI 1.2–13.7, p = 0.026), elevated lactate dehydrogenase (OR 1.7, 95% CI 1.1–2.7, p = 0.015) and higher APACHE II score (OR 2.7, 95% CI 1.3–5.4, p = 0.006) were independently associated with 60-day mortality.ConclusionPost-operative sepsis-induced ARDS is associated with higher 60-day mortality compared to non-ARDS post-operative septic patients. Post-operative septic patients with higher severity of illness have a greater risk of ARDS and worse outcomes. Further investigation is needed in post-operative sepsis-induced ARDS to prevent ARDS.