bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prolene suture-assisted cystoscopic removal of double J ureteral stents in infants
Authors: Zeng Xinhao , Lian Na , Liu Tong , Wang Xiaoyong 
Published: February 2025

ObjectivesThe purpose of this study was to describe the prolene suture-assisted cystoscopic removal of double J ureteral stents in infants and summarize the safety, operability, and effectiveness of this approach.MethodsThe clinic data of patients who underwent double J ureteral stent removal by prolene suture-assisted cystoscopy were reviewed. The operation procedure was as follows: First, a folded 4-0 prolene suture was preset into the cystoscope sheath, and the telescope was placed. Second, the cystoscopy was performed by inserting the cystoscope into the urinary bladder and finding the end of the double J ureteral stent under cystoscopy. Subsequently, the folded suture was pushed out of the sheath to form a coil that was used to hook 1–2 cm of the end of the stent. Finally, the stent was caught by tightening the prolene coil while the cystoscope was retracted into the cystoscope sheath; the removal was accompanied by exiting the cystoscope. Cystoscopy was repeated to confirm no additional damage.ResultsOverall, 15 double J ureteral stents were retrieved in 15 infants, whose average age was 3.78 ± 1.2 months, average weight was 5,951 ± 797 g, average residence time of the stents in the ureter was 31.20 ± 2.14 days, and the average operation time was 3.5 ± 1.2 min. No complications, such as urethral injury, occurred during the operation.ConclusionsProlene suture-assisted cystoscopy is one of the simple, safe, and effective technique for the removal of double J ureteral stents, especially suitable for infants or patient in whom the grasping forceps cannot pass through the matching cystoscope sheath.
Low-level neurostimulation of the renal nerves as a potential therapeutic strategy for hypertension treatment
Authors: Salman Ibrahim M. , Ameer Omar Z. , Hassan Sarah F. , Sridhar Arun , Hsieh Yee-Hsee , Lewis Stephen J. 
Published: February 2025

BackgroundNeurostimulation is an emerging treatment for conditions like hypertension. The renal nerves, comprising sensory afferent and sympathetic efferent fibers, are crucial for blood pressure (BP) regulation. The inhibitory reno-renal reflex, where central integration of renal sensory input reduces sympathetic outflow and systemic BP, presents a promising target for neurostimulation interventions. We therefore investigated renal nerve stimulation (RNS) as a potential hypertension therapy.MethodsAnesthetized male spontaneously hypertensive rats (SHRs) were subjected to low-level RNS at 0.5 mA pulse amplitude and 0.5 ms pulse width for 30 s delivered to the left intact renal nerve at 2.5 and 5.0 Hz. Mean arterial pressure (MAP), heart rate (HR), hindquarter blood flow (HQF), and ipsilateral renal cortical blood flow (RCF) were recorded. Hindquarter resistance (HQR) and renal cortical resistance (RCR) were derived from MAP and flow values.ResultsRNS significantly reduced MAP, with similar depressor responses at 2.5 (27 ± 3 mmHg) and 5.0 Hz (37 ± 8 mmHg). RNS substantially increased HQF and reduced HQR, with comparable effects at both frequencies. A 5-Hz stimulus markedly reduced RCF and increased RCR of the ipsilateral kidney. When the stimulation frequency was lowered to 2.5 Hz, the changes in RCF and RCR were nearly indistinguishable from baseline.ConclusionLow-level RNS effectively lowers BP in the SHR model of hypertension and may offer a promising therapeutic alternative for hypertension treatment. Physiologically, the observed clinically relevant reductions in BP were primarily due to reductions in vascular resistance. Adjusting stimulus levels can achieve desired hypotensive responses without compromising ipsilateral renal blood supply, typically affected by direct renal sympathetic fiber stimulation.
Half of the mothers had poor delivery referral practices in public hospitals of Bahir Dar City Northwest, Ethiopia
Authors: Fenta Abebe Amare , Atnafu Desta Debalkie , Guadie Habtamu Alganeh 
Published: February 2025

BackgroundPolicy makers and stakeholders may benefit from understanding maternal delivery referral practices as they develop efficient mechanisms to implement appropriate referral linkage. However, the practice of maternal delivery referral is not well known. This study aims to assess the maternal referral practices and associated factors among laboring mothers referred to public hospitals of Bahir Dar City, Northwest, Ethiopia.MethodIn the hospitals of the city of Bahir Dar, a facility-based cross-sectional survey was carried out from March 1 to March 30, 2021. A total of 358 mothers who came by referral to give birth at the public hospitals in Bahir Dar were interviewed using a pre-tested questionnaire that was presented by an interviewer. Data was coded, and inputted to Epi-data version 3.1 software, and after being transferred, analyzed using SPSS version 25. The associated factors linked to poor maternal referral practices were identified using bi-variable and multivariable logistic regressions. The p-value cutoff of 0.05 was ultimately determined to be statistically significant.ResultsA total of 353 study participants took part in the study. The level of poor maternal referral practice was 52.7% (95% CI 47%, 58%). The mean age of the respondents was 26.73 (± 5.45) years. Twenty eight percent of the mothers were illiterate. Unable to read and write (AOR = 2.38, 95%CI: 1.15, 4.94), read and write only (AOR = 6.59, 95%CI: 2.53, 17.17), monthly income &lt; 1,527 birr (AOR = 4.55, 95%CI: 1.91, 10.84), monthly income between 1,527 and 3,000 birr (AOR = 4.29, 95%CI: 1.76, 10.50), and monthly income between 3,001 and 5,305 birr (AOR = 3.73, 95%CI: 1.49, 9.33), referred from referral hospitals (AOR = 4.63, 95%CI: 1.94, 11.07), gave birth via cesarean section (AOR = 2.06, 95%CI: 1.22, 3.47), gave birth via assisted delivery (AOR = 4.77, 95%CI: 1.64, 13.91), and time spent more than 1 h to arrive to Bahir Dar City public hospitals (AOR = 2.15, 95%CI: 1.07, 4.34) were significantly associated with poor maternal referral practice.ConclusionPoor maternal referral practices were widespread. The use of maternal referrals was influenced by obstetric, social, environmental, and demographic factors. The poor maternal referral practices during labor should receive the most attention from mothers who have low monthly incomes and do not attend formal education.
Examining the dualistic model of passion in addiction recovery
Authors: Lewis Lauren E. , Mills Devin J. , Bergman Brandon G. , Kimball Thomas G. , Gerber William 
Published: February 2025

IntroductionAddiction recovery can be conceptualized as multidimensional changes to health and wellness including changes in substance use, physical and mental health, and social relationships. These outcomes are often measured through recovery capital which recognizes the various resources, both internal and external, that one may use to enhance their recovery. Internal and external resources can also be accumulated by engaging in an activity an individual is passionate about, explained by the dualistic model of passion (DMP) as enhancing mental and spiritual well-being, health, and personal growth, thereby fostering positive emotions, community involvement, deeper relationships, and heightened performance across various life domains. Evidence indicates that both RC and the DMP contribute to improved health outcomes including life satisfaction and well-being; however, the DMP has not yet been applied to addiction recovery science. The current study aimed to contribute to the growing body of research on addiction recovery by exploring the way passion may influence recovery outcomes. Further, the study investigated how the differences in passion type [e.g., harmonious (HP) and obsessive (OP)] impacted RC.MethodsParticipants for the study (N = 346; Mage = 42.1; 53.2% Male) included individuals who self-reported being in recovery from alcohol and/or drugs and completed an online survey through Amazon’s Mechanical Turk platform.ResultsA significant bivariate correlation was found between HP and RC (r = 0.42, p &lt; 0.001), and mean comparisons showed significant differences for individuals endorsing HP as they scored higher on a measure of RC (M = 4.69) than did their peers endorsing OP (M = 4.26). Finally, a regression analysis found that HP predicted RC (B = 0.19, p &lt; 0.001), even when time in recovery and mental health variables such as depression and anxiety were included in the model.DiscussionThis study offers novel evidence for an association between the DMP and recovery outcomes warranting future research.
Spatial encoding and growth-related change of sheep lung radiomic features
Authors: Collie David , Cousens Chris , Wright Steven , Chang Ziyuan , Meehan James , Brown Helen , Gray Calum D. , MacGillivray Tom J. , Griffiths David J. , Eckert Chad E. , Storer Nicole , Gray Mark 
Published: February 2025

IntroductionDifferent regions of the small ruminant lung exhibit variable susceptibility to specific lung pathologies. Such susceptibility may be reflected in regional lung radiomic features extracted from computed tomography (CT) images. In this study, we investigated whether region-specific variation in radiomic features exists in ovine lungs and whether these features remain stable over time.MethodsThoracic CT image datasets from 30 young adult sheep were subject to an image segmentation protocol directed at partitioning the lung into individual lobar and sub-lobar segments for radiomic feature analysis. After identifying and removing unstable, non-reproducible, and highly correlated features, 22 features remained and were used as input for principal component (PC) analysis.ResultsThe significance of segment-related influence on PC scores was determined and visualised. For six sheep, successive CT images were acquired at monthly intervals for a period of 9 months in order to assess time-dependent variation in radiomic features. The results indicated that there was a significant difference in radiomic features derived from different lung segments. Visualisation of PC scores highlighted differences between caudodorsal and cranioventral lung, between lobar and sub-lobar segments, and suggested a bias towards one lung or the other. Significant changes in PC scores occurred over time. With few exceptions, largely similar changes occurred across all segments in this regard.DiscussionOverall, our results indicate that although sheep lung radiomic features are influenced by the lung segment of origin, their variation over time is largely consistent throughout the lung. Such influence should be borne in mind when interpreting radiomic features and their changes over time.
An Experimental Study of Dolostone Recrystallization Under Fluid Overpressure and Its Implication for Reservoir Property Improvement
Authors: Chen Senran , Liu Xinshe , Wang Rong , Wei Liubin , Liu Bo , Bao Hongping 
Published: February 2025

Recrystallization is an important diagenetic process that widely occurs in carbonate rocks as a result of increasing temperature and pressure during burial. Exploration has revealed that carbonate rocks affected by recrystallization vary in their reservoir properties. To investigate the favorable development conditions of recrystallized carbonate reservoirs, we selected the crystalline dolomite reservoir of the Majiagou Formation in the Ordos Basin as the object for experimental simulation and conducted a series of dolostone recrystallization simulation experiments under various fluid pressures at 120 °C with an axial load of 55 MPa. The fluid overpressure experiments showed extensive recrystallization growth of crystals with uniform grain size and a high degree of euhedral development, and they retained the optimal porosity and pore connectivity. However, the hydrostatic pressure group had a lower degree of recrystallization and inferior physical properties compared to the overpressure group. The results indicate that fluid overpressure is a key preservation condition for deep recrystallized carbonate reservoirs. Fluid overpressure effectively preserves the initial porosity and facilitates the euhedral growth of dolostone crystals, thereby enhancing pore connectivity. Furthermore, the Kozeny–Carman equation was employed to verify that recrystallization of dolostone under fluid overpressure significantly enhances reservoir permeability by adjusting the pore structure, specifically the pore tortuosity and the pore–throat ratio. Our study demonstrates that fluid overpressure is an important prerequisite for the development of deep recrystallized carbonate reservoirs. The search for carbonate formation units with overpressure conditions such as the presence of dense layer capping may be a new direction for deep carbonate oil and gas exploration.
Правове регулювання застосування програм з виправлення та ресоціалізації засуджених за рішенням суду
Authors: Заїка Д. Є. 
Published: February 2025

У статті досліджуються законодавчі та практичні аспекти застосування програм з виправлення та ресоціалізації засуджених в Україні. Автор акцентує увагу на тому, що основною метою покарання у кримінальному праві є не лише кара, але й виправлення правопорушників, їх повернення до самокерованої правослухняної поведінки. Аналіз чинного законодавства показує, що протягом останніх років в Україні було запроваджено низку пробаційних програм, програми для кривдників та новий вид покарання – пробаційний нагляд. Водночас законодавство все ще не містить уніфікованого підходу до визначення, класифікації та систематизації таких програм, що ускладнює їх інтеграцію в систему кримінального та кримінально-виконавчого права.
На основі аналізу чинного законодавства та судової практики за період 2018–2024 років, у статті виявлено ключові проблеми правозастосування, серед яких обмежена кількість програм, недостатня різноманітність їх видів, а також відсутність чіткого механізму їх реалізації. Автор зазначає, що відсутність комплексного підходу до ресоціалізації засуджених негативно впливає на криміногенну ситуацію в державі та знижує ефективність кримінальної юстиції.
Відмічено, що відсутність єдиного підходу до визначення та класифікації таких програм, обмежена кількість і різноманітність запропонованих заходів, а також недостатня інтеграція програм у систему кримінального та кримінально-виконавчого права негативно впливають та ефективність ресоціалізації. У статті пропонуються зміни до чинного законодавства, зокрема доповнення ст. 65 Кримінального кодексу України положенням, яке дозволить суду призначати програми з виправлення та ресоціалізації як додатковий обов’язок до основного покарання.
Нормативно-правове регулювання забезпечення безпеки учасників кримінального судочинства
Authors: Бурдоль В. В. 
Published: February 2025

Стаття присвячена дослідженню питань значення системи джерел кримінального процесуального права, якими здійснюється нормативно-правове регулювання кримінальних процесуальних відносин з приводу забезпечення безпеки учасників кримінального судочинства. Відмічено, що застосування заходів безпеки під час кримінального провадження відбувається за умови обов’язкового правового опосередкування нормами галузі кримінального процесуального права. Завдяки цьому забезпечується повнота врегулювання цих відносин та чітка визначеність правової поведінки їх учасників, що має забезпечити захист життя, житла, здоров'я та майна учасника кримінального провадження від протиправних посягань. Відмічається, що основу правового регулювання застосування заходів безпеки складає кримінальне процесуальне законодавство, яке представлено виключно актами законодавства України. Але поряд з цим важливу роль у врегулюванні організаційних відносин при застосуванні заходів безпеки відіграють підзаконні у тому числі акти рекомендаційного характеру. Звертається увага, що сучасний стан нормативно-правового регулювання забезпечення безпеки учасників кримінального судочинства не позбавлений недоліків. Насамперед це стосується необхідності взаємного узгодження норм Конституції України, Кримінального процесуального кодексу України та спеціального закону. З цією метою пропонується у Кримінальному процесуальному кодексі України на рівні його завдань, як елемент засади пріоритету людини, її права та свободи та як частину системи заходів забезпечення кримінального провадження нормативно визначити та більш чітко регламентувати питання забезпечення безпеки учасників кримінального судочинства.
Identifikasi Potentially Inappropriate Medication Pasien Geriatri Dengan Beers Criteria 2023 Dan STOPP Criteria Version 3
Authors: Putra I Wayan Rama Wijaya , Prasetya Anak Agung Ngurah Putra Riana , Ratnasari Pande Made Desy 
Published: February 2025

Pasien geriatri biasanya memiliki beberapa penyakit kronis dengan peresepan obat secara polifarmasi yang beresiko terjadinya Potentially Inappropriate Medication dan menyebabkan Adverse Drug Events (ADEs) pada pasien. Penelitian ini bertujuan untuk mengidentifikasi kejadian Potentially Inappropriate Medication dengan menggunakan Beers dan STOPP Criteria serta menganalisis hubungan antara faktor risiko PIM dengan kejadian PIM. Penelitian ini merupakan penelitian retrospektif observasional secara cross-sectional. Populasi yang digunakan pada penelitian ini adalah pasien geriatri. Pengambilan data menggunakan teknik simple random sampling dengan kriteria inklusi yaitu pasien yang berusia 65 tahun keatas dengan data rekam medik lengkap, dengan kriteria eksklusi yaitu pasien yang meninggal atau dirujuk ke rumah sakit lain selama periode tahun 2023. Sebanyak 373 sampel masuk dalam kriteria inklusi pada penelitian ini. Hasil penelitian ini didapatkan sebanyak 12,06% kejadian PIM di rawat jalan dengan obat paling tinggi yaitu antihistamin generasi pertama (19,58%), benzodiazepine (15,38%), dan antipsikotik (9,09%). Sedangkan kejadian PIM di rawat inap sebesar 4,48% dengan obat yang paling tinggi yaitu kortikosteroid (20,59%), dan NSAID (11,79%). Berdasarkan hasil penelitian, diketahui terdapat korelasi yang sangat lemah antara jumlah penyakit dan jumlah obat terhadap resiko kejadian PIM.
Evaluasi Morfologi Organ Pankreas Tikus Wistar Model Diabetes Melitus oleh Ekstrak Purifikasi Daun Galing (Cayratia trifolia L. Domin) Sebagai Antidiabetes
Authors: Ilyas Y Muhammad , Bambang Bambang , Apriyanto Apriyanto , Rasak Adriatman , Jabbar Asriullah , Nasrudin Nasrudin , Wahyuni Wahyuni , Malik Fadhliyah , Halik Halik , Susanty Sry , Mubarak Mubarak , Halid Zulkifli 
Published: February 2025

Diabetes mellitus (DM) merupakan kelainan sistem endokrin ditandai dengan kadar glukosa darah melebihi normal akibat kekurangan hormon insulin yang disekresi sel beta pangkreas yang mengalami kerusakan, sehingga perbaikan sel beta pangkreas menjadi alternatif penting dalam terapi penderita DM. Tumbuhan galing (Cayratia trifolia L. Domin) dilaporkan terbukti menurunkan kadar glukosa darah pada hewan coba DM tipe 2, sehingga berpotensi dalam memperbaiki fungsi dan regenerasi sel beta pancreas pada penderita DM. Penelitian ini bertujuan untuk mengevaluasi perbaikan morfologi organ pankreas tikus putih jantan galur wistar DM setelah diberi ekstrak purifikasi daun galing. Jenis penelitian ini adalah eksperimen dengan rancangan post test with control group design, sebanyak 20 ekor tikus wistar jantan dibagi dalam kelompok kontrol normal (non DM), kontrol negatif (DM+Na.CMC), kontrol positif (DM+glibenklamid 0,09 mg/gBB) dan perlakuan sampel (DM+ekstrak purifikasi daun galing 0,4 mg/g BB). Hasil penelitian menunjukan bahwa pemberian ekstrak terpurifikasi daun galing dosis 0,4 mg/g BB terbukti memiliki efek perbaikan morfologi dan regenerasi sel endokrin pulau langerhans organ pankreas tikus wistar yang mengalami DM, sehingga dapat disimpulkan bahwa tumbuhan galing berpotensi untuk dikembangkan sebagai antidiabetes oral untuk alternatif penaganan penyakit DM tipe 2.
Potensi Aktivitas Emulgel Ekstrak Kulit Manggis (Garcinia mangostana L.) yang Mengandung Xanthon Pada Bakteri Staphylococcus epidermidis dan Staphylococcus aureus
Authors: Silvyana Annysa Ellycornia , Rahayu Feronika Evma , Suripah Suripah , Febriana Veny 
Published: February 2025

Jerawat timbul dikarenakan adanya sumbatan pada kelenjar minyak kulit, maka pelepasan minyak pada kulit tersumbat, bengkak, dan mengering menjadi isi jerawat. Jerawat pada kulit ini bisa disebabkan adanya bakteri P. acnes, S. epidermidis, S. aureus. Manggis adalah buah tropis yang mempunyai banyak keunggulan dibandingkan dengan buah lainnya. Kandungan yang terdapat di dalam kulit manggis yaitu xanton, antosianin, dan tannin. Senyawa xanton pada tanaman memiliki efek antioksidan, atimikroba, antikanker, antiinflamasi, dan aktivitas sitotoksin. Emulgel bersifat hydrofobic memiliki kemampuan tinggi menembus kulit. Emulgel yang digunakan pada kulit luar terdapat beberapa sifat yang menguntungkan seperti menjadi tiksotropik, mudah menyebar, mudah dilepas, emolient, larut dalam air, umur simpan tahan lama, ramah lingkungan, dan penampilan menarik. Penelitian aktivitas emulgel ekstrak kulit manggis (Garcinia mangostana L) yang mengandung xanton pada bakteri staphylococcus epidermidis dan staphylococcus aureus telah dilakukan. Tujuan penelitian ini untuk mengetahui apakah terdapat pengaruh formulasi emulgel ekstrak kulit manggis yang ditambah pengawet dengan formulasi tanpa penambahan pengawet. Jerawat terjadi karena adanya peradangan kelenjar minyak pada kulit, sehingga pelepasan minyak pada kulit tersumbat, bengkak serta mengering menjadi isi jerawat. Xanton merupakan senyawa yang memiliki aktivitas sebagai antibakteri sehingga pada penelitian ini dilakukan pengujian emulgel terhadap bakteri staphylococcus epidermidis dan staphylococcus aureus yang termasuk bakteri penyebab terjadi jerawat. Hasil penelitian menunjukkan bahwa emulgel xanthon tanpa penambahan memiliki aktivitas antibakteri dengan zona hambat 25 mm sedangkan pada emulgel yang ditambahkan menunjukkan zona hambat 15 mm. Hal ini diketahui bahwa emulgel ekstrak kulit manggis memiliki aktivitas antibakteri.
Formulasi dan Aktivitas Antibakteri Sediaan Tisu Basah Ekstrak Etanol Bonggol Nanas (Ananas comosus L.)
Authors: Hikma Nurul , Yusuf Muhammad , Ikhsan Mifta Kaherati 
Published: February 2025

Sumber daya alam Indonesia memiliki manfaat yang sangat besar dan beragam, salah satunya adalah bermanfaat terhadap pembuatan bahan baku kosmetik untuk kecantikan. Ada berbagai macam produk kecantikan yang telah dihasilkan dari bahan alam salah satunya adalah Tisu basah yang berfungsi sebagai antibakteri serta dapat melembabkan kulit. Penelitian ini bertujuan untuk memformulasikan ekstrak bonggol nanas (Ananas comosus L.) menjadi sediaan Tisu Basah, mengetahui stabilitas mutu fisik serta mengetahui daya terima sediaan Tisu Basah melalui uji hedonik. Sediaan Tisu Basah dibuat 4 formulasi dengan memvariasikan konsentrasi ekstrak sebanyak 3%, 4%, 5% serta tanpa ekstrak selanjutnya dilakukan pengujian seperti uji organoleptik, uji pH, uji homogenitas, uji kestabilan berat, uji antibakteri, uji iritasi kulit serta uji hedonik. Hasil penelitian menunjukkan sediaan Tisu Basah sebelum dan setelah Cycling test memiliki bau yang khas dengan warna putih gading dan tekstur yang berserat, pH 4,74-5,44, kestabilan berat 1,14%-2,70%, dapat menghambat bakteri Staphylococcus aureus pada konsentrasi 3%-5%, serta tidak mengiritasi kulit. Pada uji hedonik sebelum dan setelah Cycling test formula 2 memiliki daya terima yang baik. Ekstrak bonggol Nanas dapat diformulasikan menjadi sediaan Tisu Basah yang stabil secara fisik dan kimia serta memberikan efek antibakteri dan tidak mengiritasi kulit hewan uji.