bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐13C‐labelled 2,4‐diamino‐6‐methylpteridine
Authors: Cheung H. T. A. , Gray P. G. 
Published: October 2006

AbstractSamples of 2,4‐diamino‐6‐methylpteridine (1), specifically labelled with 13C at one or more carbon positions, were synthesised using a combination of the appropriate unlabelled and the following 13C‐labelled starting materials (ca. 90% 13C): acetone‐2‐13C, acetone‐1,3‐13C, bromoacetic acid‐1‐13C, bromoacetic acid‐2‐13C, sodium cyanide‐13C, and guanidine‐13C. The identity and site(s) of 13C of each final product and intermediate were established by 13C‐and 1H‐NMR.
Synthesis of carbon‐14 and carbon‐13 labeled 3‐methyl‐6‐[3‐(trifluoro‐methyl)phenyl]‐1,2,4‐triazolo[4,3‐b]pyridazine
Authors: May M. K. , Lanzilotti A. E. 
Published: October 2006

Abstract3‐Methyl‐6‐[3‐(trifluoromethyl)phenyl]‐1,2,4‐triazolo[4,3‐b] pyridazine (4), currently being evaluated as a potential anxiolytic agent was synthesized, labeled with carbon‐14 in the 3‐position of the triazolo nucleus. The product was obtained in 67% radiochemical yield with specific activity of 13.5 mCi/mmol and radiopurity of greater than 99%. The carbon‐13 labeled compound was also synthesized for absorption and metabolism studies.
Synthesis of stabilized tritium‐labelled 1, 3‐dioxa‐2‐hydroxypropane derivatives for use as lymphatic absorption adjuvants
Authors: Saljoughian Manouchehr 
Published: October 2006

AbstractThe synthesis of stabilized tritium‐labelled 2‐monoglycerides which may be used as lymphatic absorption adjuvants, using [carbonyl‐3H]‐benzaldehyde is described. A simple method of analysis for the regeneration of these compounds from their stabilized forms is also proposed.
Synthesis of L‐[4,4‐2H2] and D,L‐[3,3,4,4‐2H4] methionine
Authors: Ramalingara Kondareddiar , Woodard Ronald W. 
Published: October 2006

AbstractThe syntheses of D,L‐[3,3,4,4‐2H4]methionine from [2,2,2‐2H3] acetic acid in seven steps in an overall yield of 26% and L‐[4,4‐2H2]methionine from N‐t‐BOC‐L‐aspartic acid α‐benzyl ester in five steps in an overall yield of 40% are described.
Synthesis of tritium‐labelled phosphonium choline
Authors: Sim Edith 
Published: October 2006

AbstractTritium‐labeled phosphonium choline chloride ([2‐hydroxyethyl] trimethyl phosphonium chloride) has been synthesized using base‐catalyzed hydrogen exchange of the hydrogen atoms attached to the carbon adjacent to the phosphonium phosphorus. Using 3H2O diluted in 2H2O, during the exchange reaction, it is shown by proton‐NMR that substitution of the methylene protons is almost complete when only 25% of the methyl protons have exchanged. Comparison of the measured specific activity (16.12mCi/mmol) with that calculated from the total proton exchange values shows that there is a large isotope effect favouring exchange to deuterium rather than tritium.
Labeled bile acids IV: Base‐catalyzed one‐pot synthesis of deuterium labeled bile acids
Authors: Lai Chee Kong , Byon Chang Yon , Gut Marcel , Nagahisa Atsushi 
Published: October 2006

AbstractDeuterium labeled bile acids are synthesized from their keto acid analogs by a one‐pot base‐catalyzed enolization exchange with deuterated hydroxylic solvents (OD) followed by in situ reduction of the ketone. The stereochemistry of the alcohol, especially that at C‐7, can be controlled either by steric approach reduction with sodium borodeuteride or thermodynamically by reduction with sodium in n‐butanol.
Synthesis of hexadeuterated diethylstilbestrol (E‐3,4‐DI‐(4‐hydroxyphenyl) hex‐3‐ene‐1,1,1,6,6,6‐2H6)
Authors: De Clercq P. J. , Van Peteghem C. H. , Jonckheere J. A. , De Leenheer A. P. 
Published: October 2006

AbstractWe describe the synthesis of deuterated diethylstilbestrol isotopomers, starting from commercially available ketones. Attempts to synthesize E‐3,4‐di‐(4‐hydroxyphenyl) hex‐3‐ene‐2,2,5,5‐2H4 from 4‐methoxypropiophenone were not successful. Starting from 4‐methoxyacetophenone, isotopically pure E‐3,4‐di‐(4‐hydroxyphenyl)hex‐3‐ene‐1,1,1,6,6,6‐2H6 was obtained. The 3‐steps synthesis involved alkylation of the ketone with iodomethane‐1,1,1‐2H3, reductive coupling with titanium trichloride‐lithium reagent, and demethylation with trimethylsilyliodide. The possible use of the hexadeuterated diethylstilbestrol in isotope dilution mass spectrometry is demonstrated.
Tritium labelled 2‐trifluoroacetamidobenzenesulfonyl fluoride
Authors: Wyrick Steven D. , Mitchell John A. , Ranga V. 
Published: October 2006

AbstractHere, we report the synthesis of high specific activity tritiated 2‐trifluoroacetamidobenzenesulfonyl fluoridea potent elastase inhibitor. Preparation of a ring iodinated precursor followed by palladium on CaCO3 catalyzed deiodination with deuterium and tritium gas afforded high levels of isotope incorporation in both cases.
Facile synthesis of [4‐13C] butanoic acid and [4‐13C] butanol
Authors: Van Der Laan R. , Moolenaar M. J. , De Koning H. 
Published: October 2006

AbstractAlkylation of the dianion of 3‐(phenylsulfinyl) propanol with [13C] iodomethane and subsequent reductive fission of the sulfoxides gave [4‐13C] butanol that was oxidized to give [4‐13C] butanoic acid.
Synthesis of the epimeric 2‐bromocholesterols and their conversion into (2α‐3H)cholesterol and [2ß‐3H]cholesterol
Authors: Römer J. , Wagner H. , Ponsold K. 
Published: October 2006

AbstractThe synthesis of the epimeric 2‐bromocholesterols is described. Their reductive catalyzed debromination with T2 affords [2α‐3H]‐ and [2ß‐3H]cholesterol respectively. The [2‐3H] cholesterols can be synthesised with a radiochemical purity >98% and specific activities of about 600–700 GBq/mmol. The labelling reactions proceed under retention.
An evaluation of the introduction of stable nuclides of bromine into high specific activity radiobrominations
Authors: Wilbur D. S. , Garcia S. R. , Adam M. J. , Ruth T. J. 
Published: October 2006

AbstractAn investigation has been carried out to evaluate the quantity of stable nuclides of bromine that might be introduced into the reaction mixtures of high specific activity radiobrominations from the reagents used. In the investigation neutron activation analyses were performed on the radionuclide solutions, solvents, oxidizing agents, and substrates that have been used in radiobromination reactions to determine the concentrations of bromine present. All of the reagents examined had detectable quantities of bromine. Among the reagents, a large variation in the concentrations of bromine was found. Due to the quantities of bromine found and the variability of bromine concentrations in the reagents, it is suggested that the reagents used in high specific activity radiobrominations be analyzed for bromine.
Synthesis of deuterium‐labeled 1‐aminocyclopropane‐1‐carboxylic acid
Authors: Ramalingam Kondareddiar , Kalvin Douglas , Woodard Ronald W. 
Published: October 2006

AbstractThe syntheses of D,L‐1‐amino[2,2‐2H2]cyclopropane‐1‐carboxylic acid; 1‐amino [c‐2,c‐3‐2H2] and 1‐amino[t‐2,t‐3‐2H2]cyclopropane‐1‐carboxylic acid (cis‐[2H2]ACC); 1‐amino[2S,3S‐2H2] and 1‐amino[2R,3R‐2H2]cyclopropane‐1‐carboxylic acid (trans‐[2H2]ACC); and 1‐amino[2,2,3,3‐2H4]cyclopropane‐1‐carboxylic acid are described. The [2,2‐2H2]and [2,2,3,3‐2H4]ACC compounds were prepared from the appropriately deuterated 2‐bromoethanol 4‐methylbenzenesulfonates by reaction with ethyl isocyanoacetate and two moles of sodium hydride. The trans‐[2H2]ACC and cis[2H2]ACC were prepared from meso and d, l‐[1,2‐2H2]‐1,2‐dibromoethane respectively, by reaction with ethyl isocyanoacetate and two moles of sodium hydride. These compounds are required for use in the study of the biosynthesis of ethylene by various plants and for use in 1H and 13C‐NMR studies of 1‐aminocyclopropane‐1‐carboxylic acid derivatives.
Comparison of tritiation efficiency using 3H3+ and 3H2+ ion beams
Authors: Richardson B. C. , Kam Chih‐Min , Powers J. C. , Moran T. F. 
Published: October 2006

AbstractA new apparatus was constructed to tritiate biological molecules using mass analysed tritium ion beams. The magnetic sector of this device was constructed of high field Sm‐Co permanent magnets. Mass analyzed ions of desired kinetic energy were impacted on an involatile solid and 3H exchanged for H. The 3H2+ ions were found to be more reactive than 3H2+ ions. The sensitive peptide aldehyde leupeptin was utilized to test the efficacy of mass analyzed ion beam tritiation and leupeptin was not decomposed by this process.
Preparation of tritium‐labelled meta‐aminolevamisole of high specific radioactivity by catalytic dehalogenation
Authors: Lewis James A. , Paterson Ian 
Published: October 2006

AbstractWe describe the synthesis of tritiated meta‐aminolevamisole (MAL) of high specific radioactivity. Unlabelled MAL was iodinated with iodine monochloride in aqueous hydrochloric acid. The major reaction product, L[‐]2,3,5,6‐tetrahydro‐6‐(5‐amino‐2‐iodophenyl)imidazo [2,1‐b]thiazole, was catalytically dehalogenated with carrier‐free tritium gas in methanolic potassium hydroxide over 10% palladium‐carbon. After extraction and chromatography, a radioactive species ([3 H]‐MAL) was identified with the same chromatographic mobility as unlabelled MAL, [3 H]‐MAL possesses the same high biological activity in contracting nematode muscle as authentic unlabelled MAL, co‐chromatographs with unlabelled MAL in three different TLC systems and is about 90% radiochemically pure. By bioassay and competitive inhibition studies, the specific radioactivity of [3 H]‐MAL appears greater than 15 Ci/mmole and is probably close to 29 Ci/mmole. [3 H]‐MAL was shown to be useful for detecting a high affinity, saturable binding activity in extracts of the nematode Caenorhabditis elegans.
Synthesis of N‐(11C) methyl, N‐(methyl‐1 propyl), (chloro‐2 phenyl)‐1 isoquinoleine carboxamide‐3 (PK 11195): A new ligand for peripheral benzodiazepine receptors
Authors: Camsonne R , Crouzel C , Comar D , Mazière M , Prenant C , Sastre J , Moulin Ma , Syrota A 
Published: October 2006

AbstractN‐(11c) methyl, N‐(methyl‐1 propyl), (chloro‐2 phenyl)‐1 isoquinoleine carboxamide‐3 (PK 11195) or (11C) MPCI was synthetized in a short time (45 min) and high specific activity (769 Ci/mmo 1) for the positron emission tomography of peripheral benzodiazepine receptors in heart, kidney and brain. The precursor used was the N‐desmethyl MPCI (PCI). The radioactive reagent was the (11C) methyl iodide obtained from nuclear reaction 14N (p, α) 11C via 11CO2 and 11CH3OH. The chemical purity of the end‐product was checked, after HPLC purification, by chemical ionisation mass spectrometry in the parallel synthesis of cold MPCI. The methylation, reversed phase HPLC purification, evaporation times were 10, 6 min respectively so that sterile and isotonic injectable solution of (11C) MPCI ready for use may be obtained, in less than 45 min after the end of nuclear bombardment.
Synthesis of 3‐[3H]‐5‐(4′‐azobenzene arsonic acid)‐L‐tyrosine
Authors: Brundish D. E. , Wade R. 
Published: October 2006

AbstractThe title compound (ABA‐Tyr) was prepared by direct radiochemical synthesis from tritiated tert.‐butoxycarbonyl‐L‐tyrosine and diazotised arsanilic acid followed by acidolytic deprotection and isolation by preparative high pressure liquid chromatography. The product had a specific activity of 9 Ci mmol−1 and a radiochemical purity of 90–95%.
Synthesis of labelled nordihydroguaiaretic acid
Authors: Chan Carrie Y.‐C. , Leaffer M. A. , Parkhurst R. M. , Thomas D. W. , Allen L. M. , Jordan R. T. , Pardini R. S. 
Published: October 2006

AbstractMeso‐2,3‐Dimethyl‐1,4‐bis(3,4‐dihydroxyphenyl)bytane‐1‐14C, (mesonordihydroguaiaretic acid‐1‐14C, NDGA‐1‐14C), was prepared. meso‐2,3‐Dimethyl‐1‐1,4‐bis (3,4‐dihydroxy‐2,5,6‐trideuterophenyl)butane (NDGA‐d6, ring labelled) was made from acid exchange of unlabelled natural product and meso 2,3‐dimethyl‐1,4‐bis(3,4‐dihydroxyphenyl)‐1,1,2,3,4,4‐hexadeuterobutane (NDGA‐d6, chain labelled) was prepared from hydrogenation of 3,4‐dimethyl‐2,5‐bis‐(3, 4‐dimethoxyphenyl)furan using deuterium and Pd/C catalyst.
Resolution of [11C]DL‐leucine and [11C]DL‐tryptophan by high‐performance liouid chromatography
Authors: Washburn Lee C. , Sun Tan Tan , Byrd Billy L. , Callahan Alvin P. 
Published: October 2006

AbstractHigh‐performance liquid chromatographic (HPLC) resolution of [11C]DL‐leucine and [11C]DL‐tryptophan, using modifications of a previously developed technique for resolution of [11C]DL‐valine, was used to produce [11C]L‐leucine and [11C]L‐tryptophan. The technique employs commercially available reverse phase HPLC columns and chiral mobile phases containing cupric acetate and L‐proline.
Synthesis and tritium labeling of the food mutagens IQ and methyl‐IQ
Authors: Waterhouse Andrew L. , Rapoport Henry 
Published: October 2006

AbstractThe mutagens found in cooked meat, 2‐amino‐3‐methylimidazo[4,5‐f]‐quinoline (IQ) and 2‐amino‐3,4‐dimethylimidazo[4,5‐f]quinoline (Methyl ‐ IQ), have been synthesized by unambiguous methods that allow for the preparation of sufficient quantities of material for biological studies. These methods avoid difficult separations of regioisomeric mixtures of products and incorporate specific high level tritium, labeling, effected by hydrogenolysis of the appropriately substituted 5‐bromo precursors.
Generation of [75Se]dimethyl selenide and the synthesis of [75Se]dimethyleselenonium compounds
Authors: Foster Stephen J. , Kraus Richard J. , Ganther Howard E. 
Published: October 2006

AbstractThe synthesis of various [75Se]selenonium compounds of biological interest is described. [75Se]Trimethylselenonium iodide (sp. Ac. 32 mCi/mmol), prepared from commercially available [75Se]selenocystine (Foster S. J. and Ganther H. E. ‐ Anal. Biochem. 137: 205–9, 1984.) was decomposed thermally, in a stream of nitrogen, to give [75Se]dimethyl selenide, which was trapped in nitromethane at −18°C. [75Se]Dimethyl selenide was reacted, in nitromethane solution, with various alkyl halides to give dimethylselenonium compounds of the type (CH3)2Se+‐R, where R = CH2CO2H, CH2H, CH2CO2C2H5, ‐(CH2)2CO2H and ‐(CH2)2CO2C2H5. [75Se]Methyl‐selenomethionine‐selenonium iodide was synthesized from [75Se]selenomethionine and methyl iodide in a mixture of formic and acetic acids at 25°C. [75Se]Selenocystine was reduced and methylated to give [75Se]‐methylselenocysteine, which was slowly converted to [75Se]dimethyl‐selenocysteineselenonium iodide by the same reaction.
Synthesis of tritium labeled nadolol
Authors: Oatis John E. , Eller T. D. , Knapp D. R. 
Published: October 2006

AbstractTritium labeled nadolol (3) was prepared by electrophilic bromination of nadolol (1) to give 8′‐bromonadolol (2). Catalytic reductive debromination with tritium gas gave 8′‐[3H]‐nadolol (3), with a specific activity of 3.36 Ci/mmol.
Preparation of 14C‐labelled AMP, ADP AND ATP from adenine‐8‐14C by using brevibacterium ammoniagenes
Authors: Pande V. N. 
Published: October 2006

AbstractHigh radiochemical yields of 14C‐labeled adenine nucleotides (AMP, 4.6%; ADP, 15.5% and ATP, 59.5%) could be obtained by growing the cells of Brevi bacterium ammoniaqenes in the presence of 14C‐adenine. The specific radioactivity of the adenine nucleotides almost reached that of 14C‐adenine indicating negligible dilution of the label. The procedure is conveninet and especially suited for commercial preparation of the radiolabeled nucleotides directly from labeled adenine. Preliminary results indicate that the organism could also be used for the preparation of radiolabeled quanine nucleotides.
Synthesis of N‐[3‐OXO‐(4,5‐3H2)‐hexanoyl] homoserine lactone: Biologically active tritium‐labelled vibrio fischeri autinducer
Authors: Kaplan H. B. , Eberhard A. , Widrig C. , Greenberg E. P. 
Published: October 2006

AbstractN‐(3‐oxo‐4‐hexenoyl) homoserine lactone was synthesized and then reduced with Wilkinson's catalyst in the presence of tritium gas to form N‐[3‐oxo‐(4,5‐3H2)‐hexanoyl] homoserine locatone (45–55 Ci/mmol). The labelled compound was indistinguishable from the autoinducer for Vibrio fischeri luciferase [N‐(3‐oxohexanoyl) homosernine lactone] by high‐performance liquid chromatography and it was biologically active.
Production of 11C‐labeled quinidine and tamoxifen
Authors: Van Haver D. , Vandewalle T. , Slegers G. , Vandecasteele C. 
Published: October 2006

AbstractThe production of [11C] quinidine and [11C] tamoxifen for use with positron emission tomography is described. The potassium salt of O‐desmethylquinidine and N‐desmethyltamoxifen free base are treated with [11C]methyl iodide at 130°C for 10 min. After HPLC separation, the [11C‐methyl]‐labeled compounds are produced with a radiochemical yield of 60 and 70 % respectively. Injectable activities from 50 to 70 mCi are obtained 1 h after the irradiation; the specific activity is 40–60 mCi/μ mole. The entire production is controlled by a microprocessor.
Synthesis of O‐ and P‐fluoro‐α‐methylstyrenes labelled with carbon‐14 in the side chain
Authors: Ali H. M. , Barson C. A. , Coe P. L. 
Published: October 2006

AbstractOrtho‐ and para‐fluoro‐α‐methylstyrenes specifically 14C‐labelled in all three positions of the side chain have been synthesized by a modified Wittig reaction. The appropriate acetophenones were synthesized as intermediates. The yields in all cases were good and any radiochemical impurities could be readily removed by careful fractional distillation.
Synthesis of (+) and (−) [10‐14C]‐α‐ and β‐pinenes
Authors: Njar Vincent C. O. , Banthorpe Derek V. 
Published: October 2006

Abstract[10‐14C]‐(+) and (−)‐β‐Pinenes were prepared from their corresponding non‐radioactive isomers by the Wittig reaction; and the [10‐14C]‐ (+) and (−)‐α‐isomers were obtained from the [10‐14C] ‐β‐pinenes by isomerization. After purification by gas chromatography the specific activity for each of the isomers was ca. 0.025 mCimmol−1, and all the isomers had high (>90%) optical purities. All four isomers were found to be chemically (>99.5%) and radiochemically (>99.5%) pure.
The use of boron tribromide as a catalyst for the rapid tritium labeling of aromatic compounds
Authors: Garnett John L. , Long Mervyn A. , Lukey Christopher A. 
Published: October 2006

AbstractBoron tribromide has been assessed as a catalyst for rapid tritium labeling of organic compounds using tritiated water under mild conditions. Alkyl and halogen substituted aromatics labeled rapidly, the labeling being most pronounced in the ortho and para positions. Compounds containing electrophilic deactivating groups were found to be difficult to label. Very little byproduct formation was observed.
The syntheses of no‐carrier‐added and carrier‐added 18F‐labelled haloperidol
Authors: Farrokhzad Simin , Diksic Mirko 
Published: October 2006

AbstractFluorine‐18 labelled haloperidol (18F‐HP) was synthesized by a fluorine‐fluorine exchange reaction on haloperidol, fluorine‐chlorine exchange on a chloro‐analog of haloperidol, and from 18F‐labelled p‐fluorobenzonitrile prepared by two different exchange reactions. Nucleophilic fluorine was used in the form of tetra n‐butylammonium fluoride. The overall radiochemical yield, expressed at the end of syntheses was 5% for exchange in haloperidol and about 2%‐3% for exchange in chloroanalog in a 40 min synthesis (from the end of the irradiation). Specific activity up to 1 Ci/mmol for haloperidol and up to 5000 Ci/mmol for chloro‐analog as substrates were obtained. The syntheses using p‐substituted chloro‐and nitro‐benzonitriles as starting materials for the exchange reaction gave a product with an average specific activity of about 2000 Ci/mmol and in general an overall radiochemical yield of 5%–10%. Purification of [18F]haloperidol was done by HPLC on a C‐18 column. The radiochemical purity as assessed by thin layer radiochromatography (TLRC) of the final product was at least 95%, with high chemical purity.
Synthese des Metabolites de L'Insecticide Deltamethrine : Acides Phenoxy‐3 Benzoiques (carboxyle 14C), Alcools Phenoxy‐3 Benzyiques (hydroxyméthyle 14C)
Authors: Do‐Cao‐Thang  , Nguyen‐Hoang‐Nam  , Hoellinger H. , Pichat L. 
Published: October 2006

AbstractProcedures are described for the synthesis of the following metabolites of deltamethrin, the pyrethroid insecticide: 3‐phenoxy (carboxyl‐14C) benzoic acid, 3‐(2′‐hydroxyphenoxy) (carboxyl‐14C) benzoic acid and the corresponding 3‐phenoxybenzyl alcohols, specific activity = 47–57 mCi/mmol.
The synthesis of spiromustine ‐d8. A general approach to octadeuterated nitrogen mustards
Authors: Huguenin Philipp N. , Kelley James A. 
Published: October 2006

AbstractThe synthesis of deuterium labelled spiromustine, a potential new antitumor agent designed specifically for neoplasms of the central nervous system, is described. Eight deuterium atoms have been incorporated specifically into the nitrogen mustard moiety to provide a deuterated internal standard suitable for selected ion monitoring by GC/MS. Starting with ethylene glycol‐d6, diethanolamine‐d8 is produced efficiently in good yield with no deuterium exchange via a 2‐imino‐1,3‐oxazolidine intermediate. The resultant diethanolamine‐d8 may then be used to synthesize spiromustine‐d8 or other octadeuterated nitrogen mustards.
Synthesis of 13C single and double labelled retinals, precursors for NMR studies of visual pigments and related systems
Authors: Iqbal M. , Copan W. G. , Muccio D. D. , Mateescu G. D. 
Published: October 2006

AbstractThe synthesis of retinals enriched with 13C at positions 11, 13, 14, 15, 12&20, 13&14, and 14&15 in high isomeric purity is reported. The importance of these retinals in studying the structure and properties of rhodopsin and bacteriorhodopsin by 13C NMR spectroscopy is briefly described.
Synthesis of a new class of retinoid, 3H‐labelled TTNPB, 1 with a high specific activity
Authors: Rhee Sung W. , Degraw Joseph I. , Kaegi Heinz H. 
Published: October 2006

AbstractSynthetic procedures for tritiation of a retinodal benzoic acid derivative, (E)‐4‐[2‐(5,6,7,8‐tetrahydro‐5,5,8,8‐tetramethyl‐2‐naphthalenyl‐6,7‐ 3H2)‐1‐propenyl]‐benzoic acid, (TTNPB), are described. Tritium was introduced by catalytic hydrogenation. The final product, TTNPB‐3H2 (9), had a specific activity of 24.1 Ci/mmole and a radiochemical purity of 95.6%.
Utilisation de L'Ethanolamine14C Comme Precurseur 1ère Partie : Marquage de la N'‐(Chloro‐2 Ethyl) N‐[(Methyl Sulfinyl)‐2 Ethyl] N'‐Nitrosouree et de la N'‐(Chloro‐2 Ethyl) N‐[(Methyl Sulfonyl)‐2 Ethyl] N'‐Nitrosouree Par 14C
Authors: Madelmont J. C. , Parry D. , Godeneche D. , Duprat J. 
Published: October 2006

AbstractDeux nouvelles chloro 2 ethyl nitrosourées ont été marquées en deux positions par le 14C ` partir de Nal14CN en utilisant l'éthanolanine 14C comméinter:

‐ sur le carbone 2 du groupe chloro 2 ethyl
‐ sur le carbone 2 de la partie cystéarnine.
Synthesis of nedocromil sodium labelled with tritium, deuterium and carbon‐14
Authors: Wilkinson D J , Lockley W J S 
Published: October 2006

AbstractNedocromil sodium labelled with carbon‐14 has been prepared by a Claisen reaction between diethyl [1,2‐14C]‐ethanedioate and methyl 6‐ethanoyl‐1‐ethyl‐1,4‐dihydro‐7‐hydroxy‐4‐oxo‐8‐propylquinoline‐2‐carboxylate. The 2H‐ and 3H‐labelled materials are readily prepared by rhodium(III) chloride catalysed exchange with the appropriate isotopically labelled water.
Synthesis of specifically‐labelled tritiated benzimidazole carbamates
Authors: Lacey E. 
Published: October 2006

AbstractBenzimidazole carbamates are thought to exert their biological activity as anthelmintics by binding to helminth tubulin. To investigate this hypothesis, the synthesis of two specifically‐labeled tritiated benzimidazoles, parbendazole and oxibendazole, has been accomplished. These labels were prepared by debromination of the appropriate 5‐bromo analogue using sodium borotritide in the presence of palladium chloride. The brominated derivatives were synthesized by the bromination of the benzimidazole using bromine in glacial acetic acid.