bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chinese herbal medicines for the treatment of depression: a systematic review and network meta-analysis
Authors: Dang Chun , Wang Qinxuan , Li Qian , Xiong Ying , Lu Yaoheng 
Published: April 2024

Objectives: Amidst rising global burden of depression and the associated challenges with conventional antidepressant therapies, there is a growing interest in exploring the efficacy and safety of alternative treatments. This study uses a Bayesian network meta-analysis to rigorously evaluate the therapeutic potential of Chinese herbal medicines in the treatment of depression, focusing on their comparative efficacy and safety against standard pharmacological interventions.Methods: Five databases (PubMed, Wanfang Data, EMBASE, CNKI, and the Cochrane Library) and grey literature were searched from inception to end of July 2023 to identify studies that assessed the efficacy and safety of Chinese herbal medicines in treating depression. The response rate, Hamilton Depression Scale (HAMD) scores, and rates of adverse events were assessed through both direct and indirect comparisons. Data extraction and risk of bias assessment were meticulously performed. Statistical analysis used Markov chain Monte Carlo methods, with effect size estimates provided as odd ratios and their 95% confidence intervals.Results: A total of 198 RCTs involving 8,923 patients were analyzed, assessing 17 Chinese herbal medicines. Surface Under the Cumulative Ranking results indicated that the top three treatments with the best response rate were possibly Guipiwan, Ease Pill, and Chaihu Jia Longgu Muli Decoction; the top three treatments on the reduction of HAMD scores were Chai Hu Shu Gan San, Xingnao Jieyu Decoction, and Xiaoyao Powder; and the top three treatments with the lowest adverse effects rates were Xiaoyao Powder, Alprazolam, and Xingnao Jieyu Decoction. Interestingly, commonly used synthetic drugs such as Fluoxetine, Escitalopram, Amitriptyline, Sertraline, Flupentixol and Melitracen, and Venlafaxine, not only appeared to be less effective than specific Chinese herbal medicines (Gan Mai Da Zao Decoction, Chaihu Jia Longgu Muli Decoction, Chai Hu Shu Gan San, Danzhi-Xiaoyao-San, and Xingnao Jieyu Decoction), but they were also related to substantially higher risk of adverse events.Conclusion: Our findings elucidate the promising therapeutic potential of Chinese herbal medicines as viable alternatives in the treatment of depression, with certain herbs demonstrating enhanced efficacy and safety profiles. The outcomes of this study advocate for the integration of these alternative modalities into contemporary depression management paradigms. However, it underscores the necessity for larger, methodologically robust trials to further validate and refine these preliminary findings.Systematic review registration:https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023452109.
Association of exposure to multiple perfluoroalkyl and polyfluoroalkyl substances and glucose metabolism in National Health and Nutrition Examination Survey 2017–2018
Authors: Tian Qinghua , Yang Yutong , An Qi , Li Yang , Wang Qingyao , Zhang Ping , Zhang Yue , Zhang Yingying , Mu Lina , Lei Lijian 
Published: April 2024

ObjectiveTo investigate the relationships between perfluoroalkyl and polyfluoroalkyl substances (PFASs) exposure and glucose metabolism indices.MethodsData from the National Health and Nutrition Examination Survey (NHANES) 2017–2018 waves were used. A total of 611 participants with information on serum PFASs (perfluorononanoic acid (PFNA); perfluorooctanoic acid (PFOA); perfluoroundecanoic acid (PFUA); perfluorohexane sulfonic acid (PFHxS); perfluorooctane sulfonates acid (PFOS); perfluorodecanoic acid (PFDeA)), glucose metabolism indices (fasting plasma glucose (FPG), homeostasis model assessment for insulin resistance (HOMA-IR) and insulin) as well as selected covariates were included. We used cluster analysis to categorize the participants into three exposure subgroups and compared glucose metabolism index levels between the subgroups. Least absolute shrinkage and selection operator (LASSO), multiple linear regression analysis and Bayesian kernel machine regression (BKMR) were used to assess the effects of single and mixed PFASs exposures and glucose metabolism.ResultsThe cluster analysis results revealed overlapping exposure types among people with higher PFASs exposure. As the level of PFAS exposure increased, FPG level showed an upward linear trend (p &lt; 0.001), whereas insulin levels demonstrated a downward linear trend (p = 0.012). LASSO and multiple linear regression analysis showed that PFNA and FPG had a positive relationship (&gt;50 years-old group: β = 0.059, p &lt; 0.001). PFOA, PFUA, and PFHxS (≤50 years-old group: insulin β = −0.194, p &lt; 0.001, HOMA-IR β = −0.132, p = 0.020) showed negative correlation with HOMA-IR/insulin. PFNA (&gt;50 years-old group: insulin β = 0.191, p = 0.018, HOMA-IR β = 0.220, p = 0.013) showed positive correlation with HOMA-IR/insulin, which was essentially the same as results that obtained for the univariate exposure-response map in the BKMR model. Association of exposure to PFASs on glucose metabolism indices showed positive interactions between PFOS and PFHxS and negative interactions between PFOA and PFNA/PFOS/PFHxS.ConclusionOur study provides evidence that positive and negative correlations between PFASs and FPG and HOMA-IR/insulin levels are observed, respectively. Combined effects and interactions between PFASs. Given the higher risk of glucose metabolism associated with elevated levels of PFAS, future studies are needed to explore the potential underlying mechanisms.
In search of socially responsible investors: a Latent Profile Analysis
Authors: Robba Matteo , Sorgente Angela , Iannello Paola 
Published: April 2024

IntroductionSocially responsible investments (SRI) increased their popularity among investors over the last two decades. However, there is still a lack of knowledge on socially responsible investors' characteristics and motivations behind the decision to invest in SRI. The present paper aims at filling this gap by profiling current and potential sustainable investors.MethodCross-sectional data from a representative sample of Italian consumers (N = 1,002) was used to perform a Latent Profile Analysis (LPA), a clustering technique, and identify various sub-groups within the respondents. Subsequently, chi-square test and one-way ANOVA were performed to determine which profile(s) was mostly associated with current and potential socially responsible investing.Results and discussionFive profiles of consumers were identified through the LPA, each one differently associated with the likelihood of investing in socially responsible products. The profile that best describes sustainable investors is characterized by high levels of knowledge toward SRI, risk appetite, positive attitudes on SRI, personal norms, perceived behavioral control, environmental concerns, and connectedness to nature. These findings suggest that non-financial aspects, namely psychological characteristics such as attitudes and personal values, play a key role in the decision to invest responsibly as well.
Recurrent gastric antral vascular ectasia: a single center experience
Authors: Cavallaro Andrea , Zanghì Antonio , Di Vita Maria , Catania Vito Emanuele , Longo Giovanni , Lo Menzo Emanuele , Granata Roberta , Valenti Maria Rosaria , Cappellani Alessandro , Di Majo Simone 
Published: April 2024

IntroductionGastric antral vascular ectasia (GAVE) is a rare cause of chronic or acute gastrointestinal bleeding. This condition accounts for ∼4% of upper gastrointestinal bleeding cases. This disease is often associated with systemic diseases, such as liver cirrhosis, chronic kidney failure, autoimmune conditions, diabetes mellitus, hypothyroidism, and cardiovascular diseases. However, its etiopathogenesis remains controversial.Materials and methodWe retrospectively reviewed the cases of GAVE treated at our digestive surgery unit. A total of nine patients were identified with a male/female ratio of 1.25:1 and an average age of 75.51 years (SD ± 9.85). All patients underwent endoscopic argon plasma coagulation (APC) treatment. At the time of the review, data on eight patients were available after 36 months of follow-up.ResultsAPC appears to be safe and effective for hemostasis of bleeding vascular ectasia. Only one (11.1%) patient required surgical intervention due to hemodynamic instability after multiple unsuccessful endoscopic treatments. No intraoperative and postoperative complication or bleeding relapse was experienced.DiscussionBased on our findings, we concluded that endoscopic APC is technically simple, but requires multiple re-interventions due to the incidence of relapses. Furthermore, larger randomized studies should be conducted to assess the role of elective surgery as the first intervention in stable patients with severe pathology and the timing of surgery after failed endoscopic treatment.
Motilin, a Novel Orexigenic Factor, Involved in Feeding Regulation in Yangtze Sturgeon (Acipenser dabryanus)
Authors: Tang Ni , Li Ya , Li Yingzi , Xu Shaoqi , Wang Mei , Wang Bin , Liu Yanling , Zhang Shupeng , Wu Hongwei , Zhang Xin , Zhou Bo , Li Zhiqiong 
Published: April 2024

Motilin is a gastrointestinal hormone that is mainly produced in the duodenum of mammals, and it is responsible for regulating appetite. However, the role and expression of motilin are poorly understood during starvation and the weaning stage, which is of great importance in the seeding cultivation of fish. In this study, the sequences of Yangtze sturgeon (Acipenser dabryanus Motilin (AdMotilin)) motilin receptor (AdMotilinR) were cloned and characterized. The results of tissue expression showed that by contrast with mammals, AdMotilin mRNA was richly expressed in the brain, whereas AdMotilinR was highly expressed in the stomach, duodenum, and brain. Weaning from a natural diet of T. Limnodrilus to commercial feed significantly promoted the expression of AdMotilin in the brain during the period from day 1 to day 10, and after re-feeding with T. Limnodrilus the change in expression of AdMotilin was partially reversed. Similarly, it was revealed that fasting increased the expression of AdMotilin in the brain (3 h, 6 h) and duodenum (3 h), and the expression of AdMotilinR in the brain (1 h) in a time-dependent manner. Furthermore, it was observed that peripheral injection of motilin-NH2 increased food intake and the filling index of the digestive tract in the Yangtze sturgeon, which was accompanied by the changes of AdMotilinR and appetite factors expression in the brain (POMC, CART, AGRP, NPY and CCK) and stomach (CCK). These results indicate that motilin acts as an indicator of nutritional status, and also serves as a novel orexigenic factor that stimulates food intake in Acipenser dabryanus. This study lays a strong foundation for the application of motilin as a biomarker in the estimation of hunger in juvenile Acipenser dabryanu during the weaning phase, and enhances the understanding of the role of motilin as a novel regulator of feeding in fish.
Armenian Cochineal and the Red Color of Armenia in Russian Literature
Authors: Keshfidinov Shevket , Shafranskaya Eleonora 
Published: April 2024

The article examines the genesis of the red color, which acts as a pattern of the «Armenian text of Russian literature» on the basis of Russian poetic texts (B. Pasternak, F. Sologub, O. Mandelstam, N. Konchalovskaya, P. Antokolsky, I. Snegova, P. Pyanykh, L. Shahverdyan) and prose (B. Kuzin, O. Mandelstam,
Yu. Karabchievsky, M. Saryan, V. Grossman). The subject of the article is the connection of the insect code presented in the discourse with the color red. Analytics is based on biographical, quantitative methods, linguistic analysis of the text and is carried out on the basis of a historical and cultural approach. The
recent works that reveal the patterns of the «Armenian text» do not mention the connection between cochineal and red color metaphors found in this article. The conclusions obtained enrich the cultural and philological concept contained in the framework of the «Armenian text» and expand the poetic context of the biological organism mentioned in the poems of Russian poets. The article presents an additional (to the already existing) perspective in the analysis of O. Mandelstam's poem «Inside the mountain, an idol is inactive...»: the image of the idol is
embedded in an ekphrastic sculptural row with the mythological Golem.
Somnambulistic
(A Wreath of Sonnets by M.A. Voloshin «Lunaria»)
Authors: Linnik Yury 
Published: April 2024

Shortly before his death, the outstanding stephanist and stephanologist from Petrozavodsk, Yuri Vladimirovich Linnik, sent me, as the Chairman of the International Scientific and Creative Seminar School of the Sonnet, two of his poetological essays for publication in the next issue of the almanac «Wreath of
Sonnetologists and Sonnetists». The received grant makes it possible to publish both the essays themselves and the comments adequate to them. Both of them are devoted to the pioneering experiments of Maximilian Voloshin, the author of two wreaths –«Corona Astralis», 1909, and «Lunaria», 1913, in which a new unheard-of genre-strophic form was first tested in relation to the philosophy of cosmism. This issue, in resonance with the predilection for stephanistics, most of all occupied Linnik himself. Linnik's metapoetic interpretation of two masterpieces
of his predecessor will be of undoubted interest both for researchers of sonnet wreaths and for poets who cultivate them in their work. This time we bring to the attention of readers the second essay «Somnambulistic». The first one, we hope,
will be published by our Kazakh colleagues.
Sublines of Omicron Genovariant of SARS-CoV-2 Virus as Potential Dominant Agents of New Rises of COVID-19 Morbidity in Russia
Authors: Sizikova T. E. , Karulina N. V. , Petrov A. A. , Lebedev V. N. , Borisevich S. V. 
Published: April 2024

The analysis of existing information about invasion of COVID-19 in Russia shows that that one of leading reason of existing of new rises of covid-19 morbidity is distribution of new genovariants of SARS-CoV-2 virus. The omicron genovariant of SARS-CoV-2 virus was a dominant agent of fifth and subsequent rises of COVID-19 morbidity in Russia. The aim of this work – the estimation of sublines of omicron genovariant of SARS-CoV-2 virus as potential dominant agents of new rises of COVID-19 morbidity in Russia. The source base of the study. Data published in Russian and English-language scientific publications available via the Internet (RSCI, PubMed, Google Scholar). The research method is analytical. Results. The basic properties of omicron genovariant of SARS-CoV-2 virus, epidemical characteristics of the rises of COVID-19 morbidity in Russia, caused by new sublines of omicron variant, estimation ofsublines of omicron genovariant as potential dominant agent of new rises of COVID-19 morbidity in Russia are viewed. It is shown that basic direction of SARS-CoV-2 virus evolution is existing of sublines of omicron genovariant, which are characterized by increased transmissivity but with less severity of the disease caused compared to previously circulated variants of COVID-19agent. The main distinguishing feature of the new subvariants («Kraken», «Czerber», «Centaur», «Arktur», «Pirola») are multiple amino acid exchanges in structural glycoprotein S. The maximum level of variability of this structural protein compared to the original variant of SARS-CoV-2 virus is marked for Pirola subvariant. Onle Kraken subvariant was dominant agent of rise of COVID-19 morbidity in Russia. Conclusion. New rises of COVID-19 morbidity in Russia will not be connected with existing of new subvariants of omicron genovariant, but only with season factor.
Approbation of the Technology for Constructing Means of Express Indication of New Especially Dangerous
Authors: Petrov A. A. , Kazantsev A. V. , Panferov K. A. , Chislov A. A. , Kovalchuk E. A. , Kutaev D. A. , Borisevich S. V. 
Published: April 2024

Catastrophic pandemic of the particularly dangerous coronavirus SARS-CoV-2 in 2020–2022 and the unexpected spread of the monkeypox pathogen from Africa in 2022, demonstrate the need for an adequate response to biological threats that have exotic infections as their source, overcome the interspecies barrier between animals and humans and have high rates of virulence and contagiousness in relation to the latter. The purpose of the article is to create a technology for constructing means for the express indication of new especially dangerous and exotic infections, which makes it possible to quickly develop a gene diagnostic tool, evaluate its characteristics and launch large-scale production. Materials and methods. The authors used technologies for constructing means for express indication of new especially dangerous and exotic infections based on real-time polymerase chain reaction (RT-PCR-RT-Flu/ Coronavirus) methods, suitable for multiplex identification of coronavirus RNA. The discussion of the results. The developed technology for constructing means for express indication of new especially dangerous and exotic infections was successfully tested at the laboratory base of the FSBЕ «48 Central Research Institute» of the Ministry of Defense of the Russian Federation using the example of designing a «Set of reagents for detecting the RNA of coronaviruses SARS-CoV, MERS-CoV, SARS-CoV-2 and virus influenza A by real-time polymerase chain reaction (RT-PCR-RT-Flu/Coronavirus)», suitable for multiplex identification of coronavirus RNA. Conclusion. As a result of the research carried out to evaluate the equipment available at the laboratory base of the FSBЕ «48 Central Research Institute» of the Ministry of Defense of the Russian Federation, the adaptation and implementation of key production processes, the development and production of express-indication reagents, as well as testing the technology for constructing express-indication means for new especially dangerous and exotic infections, using the example of designing a set of RT-PCR-RV-Flu/Coronavirus reagents, a gene diagnostic platform was created for the development of reagents for the express indication of new especially dangerous and exotic infections.
KONSEP KEBAHAGIAAN SEJATI DARI PERSPEKTIF STOISISME DALAM FILM SEPATU DAHLAN
Authors: Septiani Rifanny Zahra , Syihabuddin Syihabuddin 
Published: April 2024

Penelitian ini menganalisis konsep kebahagiaan sejati pada film "Sepatu Dahlan" yang dilihat dari kacamata filosofi stoisisme. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana film ini mendefinisikan kebahagiaan sejati dan menganalisis penggambaran tindakan tokoh-tokoh dalam film untuk mencapai kebahagiaan sejati. Penelitian ini menggunakan metode kualitatif dengan analisis semiotika dari Ferdinand De Saussure. Untuk menganalisis data, penelitian ini menggunakan teori filosofi stoisisme dalam buku Filosofi Teras oleh Henry Manampiring yang dilandasi pemikiran filsuf-filsuf stoisisme seperti Seneca, Epictetus, dan Kaisar Marcus Aurelius. Temuan penelitian menunjukkan bahwa film ini mendefinisikan kebahagiaan sejati melalui tindakan tokoh-tokoh dalam film yang didorong oleh dikotomi kendali yaitu aspek-aspek yang bisa kita kendalikan untuk mencapai kebahagiaan sejati antara lain:hidup bebas dari emosi negatif dan hidup penuh kebajikan: kebijaksanaan, keadilan, keberanian, menahan diri. Hidup bebas dari emosi negatif digambarkan ketika karakter bisa mengendalikan diri untuk tidak merasa sedih, marah, khawatir dan kecewa saat menghadapi kejadian-kejadian yang menimpa di kehidupannya. Hidup penuh kebajikan digambarkan ketika karakter bisa menggunakan nalar atau rasionalitasnya dengan baik.
Entomocomplex of Radish in Open-field Cultivation in the Central Part of the Right-Bank Forest-Steppe of Ukraine
Authors: Shchetina S. , Mostoviak I. , Fedorenko V. 
Published: April 2024

Goal. To specify the species composition of insect pests affecting radish (Raphanus sativus (L.) convar. radicula (Pers) Sazon.) in open-field cultivation conditions in the central part of the Right-Bank Forest-Steppe of Ukraine.
Methods. The study was conducted following commonly accepted methods in entomology and vegetable growing. From 2008 to 2022, we investigated the species diversity of insects, dominant species, their abundance, and the structure of the harmful entomocomplex in radish crops grown in open-field conditions on household plots and farms in the Cherkasy region.
Results. In the entomological complex of radish, 59 species of phytophagous insects from 20 families and 8 orders were identified: Coleoptera — 29%, Lepidoptera — 27%, Homoptera — 15%, Diptera — 10%, Orthoptera — 9%, Thysanoptera — 5%, Hemiptera — 3%, Hymenoptera — 2%. Sixteen dominant species of phytophagous insects were found in radish crops, including diamondback moth (Plutella maculipennis Curt.), crucifer flea beetles (Phyllotreta cruciferae Goeze), striped flea beetle (Phyllotreta undulata Kutsch.), cabbage white butterfly (Pieris brassicae L.), turnip moth (Agrotis segetum Denis&Schiff.) and owlet moth (Lacanobia oleracea L.), crucifer shield bug (Eurydema ventralis Kol.), cabbage aphid (Brevicoryne brassicae L.), spring root maggot (Delia brassicae Bouche) and summer root maggot (Delia floralis Fallen), seedcorn maggot (Delia platura Mg.), sawfly (Athalia rosae L.), stem weevil (Ceutorrhynchus quadridens Panz.), tobacco thrips (Thrips tabaci Lindeman), turnip sawfly (Entomoscelis adonidis Pallas), and crucifer webworm (Evergestis extimalis Scop.). Through multi-year studies, the periods of insect damage corresponding to radish developmental stages were determined. The most critical damage to radish plants by harmful insects occurred during the initial stages of development (ВВСН 0—9) and from emergence to the growth and formation of the root crop (BBCH 42—48).
Conclusions. It was found that among the identified phytophagous insects in radish crops, the most economically significant damage was caused by the cabbage aphid, crucifer flea beetles, striped flea beetle, spring cabbage fly, and seedcorn maggot. On average over the research period (2008—2022), the largest areas of radish crops were infested by the diamondback moth, crucifer flea beetles, and striped flea beetle, cabbage white butterfly, winter and owlet moths, cabbage shield bug, and cabbage aphid, ranging from 5% to 80%, reaching a maximum in some years up to 60—100% of the area.