bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymorphism in nucleotide excision repair gene XPC correlates with bleomycin‐induced chromosomal aberrations
Authors: Laczmanska Izabela , Gil Justyna , Karpinski Pawel , Stembalska Agnieszka , Trusewicz Alicja , Pesz Karolina , Ramsey David , Schlade‐Bartusiak Kamilla , Blin Nikolaus , Sasiadek Maria Malgorzata 
Published: August 2007

AbstractChromosomal aberrations (CAs) are important genetic alterations in the development and progression of the majority of human cancers. The frequency with which such alterations occur depends to a large extent on polymorphisms of DNA‐repair genes and in genes coding for xenobiotic metabolizing enzymes, which are involved in the processes of activation and inactivation of xenobiotics. The frequency of bleomycin (BLM)‐induced CAs is an indirect measure of the effectiveness of DNA repair mechanisms, and a predictor of environment‐related risk of cancer. Our study was conducted on the human peripheral blood lymphocytes of 82 healthy volunteers. The aim of the study was to elucidate whether the frequency of BLM‐induced CAs is correlated with polymorphisms of selected genes involved in different mechanisms of DNA repair such as: XRCC1 [base excision repair]; XPA, XPC, XPG, XPD, XPF, ERCC1 [nucleotide excision repair], NBS1, RAD51, XRCC2, XRCC3, RAD51, and BRCA1 [homologous recombination], as well as in genes encoding xenobiotic metabolizing enzymes, such as CYP1A, CYP2E1, NAT2, GSTT1, and EPHX (mEH). Our study indicated that, of the polymorphisms studied, only XPC (exon 15 and intron 11) is associated with BLM‐induced CAs, suggesting a role of the NER pathway in the repair of BLM‐induced chromosomal aberrations. Environ. Mol. Mutagen., 2007. © 2007 Wiley‐Liss, Inc.
On the dynamics of rocking motion of single rigid‐block structures
Authors: Peña F. , Prieto F. , Lourenço P. B. , Campos Costa A. , Lemos J. V. 
Published: August 2007

AbstractThis paper describes the behavior of single rigid‐block structures under dynamic loading. A comprehensive experimental investigation has been carried out to study the rocking response of four blue granite stones with different geometrical characteristics under free vibration, and harmonic and random motions of the base. In total, 275 tests on a shaking table were carried out in order to address the issues of repeatability of the results and stability of the rocking motion response. Two different tools for the numerical simulations of the rocking motion of rigid blocks are considered. The first tool is analytical and overcomes the usual limitations of the traditional piecewise equations of motion through a Lagrangian formalism. The second tool is based on the discrete element method (DEM), especially effective for the numerical modeling of rigid blocks. A new methodology is proposed for finding the parameters of the DEM by using the parameters of the classical theory. An extensive comparison between numerical and experimental data has been carried out to validate and define the limitations of the analytical tools under study. Copyright © 2007 John Wiley & Sons, Ltd.
Apparent damping induced by spurious pitching in shaking‐table testing
Authors: Molina F. J. , Magonette G. , Viaccoz B. , Géradin M. 
Published: August 2007

AbstractA seismic shaking‐table test performed on a one‐storey steel frame with an 8 ton RC floor slab was reproduced on a similar specimen by means of the pseudo‐dynamic (PsD) method. A satisfactory agreement of the results could only be achieved after recalibration of the theoretical mass in the PsD equation and proper inclusion in the PsD test input of the horizontal and pitching accelerations measured on the table. In the shaking‐table test, the spurious pitching motion produced a significant increase in the apparent damping that could be estimated as a function of the pitching dynamic flexibility of the system. Dynamic and PsD snap‐back tests were also performed to provide an additional check of the reliability of the PsD method. The spurious pitching motion of the shaking table should always be measured during the tests and reported as a mean to increase the reliability and
usefulness of the results. Copyright © 2007 John Wiley & Sons, Ltd.
Modeling the spatial distribution of landslide‐prone colluvium and shallow groundwater on hillslopes of Seattle, WA
Authors: Schulz William H. , Lidke David J. , Godt Jonathan W. 
Published: August 2007

AbstractLandslides in partially saturated colluvium on Seattle, WA, hillslopes have resulted in property damage and human casualties. We developed statistical models of colluvium and shallow‐groundwater distributions to aid landslide hazard assessments. The models were developed using a geographic information system, digital geologic maps, digital topography, subsurface exploration results, the groundwater flow modeling software VS2DI and regression analyses. Input to the colluvium model includes slope, distance to a hillslope–crest escarpment, and escarpment slope and height. We developed different statistical relations for thickness of colluvium on four landforms. Groundwater model input includes colluvium basal slope and distance from the Fraser aquifer. This distance was used to estimate hydraulic conductivity based on the assumption that addition of finer‐grained material from down‐section would result in lower conductivity. Colluvial groundwater is perched so we estimated its saturated thickness. We used VS2DI to establish relations between saturated thickness and the hydraulic conductivity and basal slope of the colluvium. We developed different statistical relations for three groundwater flow regimes. All model results were validated using observational data that were excluded from calibration. Eighty percent of colluvium thickness predictions were within 25% of observed values and 88% of saturated thickness predictions were within 20% of observed values. The models are based on conditions common to many areas, so our method can provide accurate results for similar regions; relations in our statistical models require calibration for new regions. Our results suggest that Seattle landslides occur in native deposits and colluvium, ultimately in response to surface‐water erosion of hillslope toes. Regional groundwater conditions do not appear to strongly affect the general distribution of Seattle landslides; historical landslides were equally dispersed within and outside of the area potentially affected by regional groundwater conditions. Published in 2007 by John Wiley & Sons, Ltd.
GIS‐based regional landslide susceptibility mapping: a case study in southern California
Authors: He Yiping , Beighley R. Edward 
Published: August 2007

AbstractLandslides threaten lives and property throughout the United States, causing in excess of $2 billion in damages and 25–50 deaths annually. In regions subjected to urban expansion caused by population growth and/or increased storm intensities caused by changing climate patterns, the economic and society costs of landslides will continue to rise. Using a geographic information system (GIS), this paper develops and implements a multivariate statistical approach for mapping landslide susceptibility. The presented susceptibility maps are intended to help in the design of hazard mitigation and land development policies at regional scales. The paper presents (a) a GIS‐based multivariate statistical approach for mapping landslide susceptibility, (b) several dimensionless landslide susceptibility indexes developed to quantify and weight the influence of individual categories for given potential risk factors on landslides and (c) a case study in southern California, which uses 11 111 seismic landslide scars collected from previous efforts and 5389 landslide scars newly digitized from local geologic maps. In the case study, seven potential risk factors were selected to map landslide susceptibility. Ground slope and event precipitation were the most important factors, followed by land cover, surface curvature, proximity to fault, elevation and proximity to coastline. The developed landslide susceptibility maps show that areas classified as having high or very high susceptibilities contained 71% of the digitized landslide scars and 90% of the seismic landslide scars while only occupying 26% of the total study area. These areas mostly have ground slopes higher than 46% and 2‐year, 6‐hour precipitation greater than 51 mm. Only 12% of digitized landslides and less than 1% of recorded seismic landslides were located in areas classified as low or very low susceptibility, while occupying 42% of the total study region. These areas mostly have slopes less than 27% and 2‐year, 6‐hour precipitation less than 41 mm. Copyright © 2007 John Wiley & Sons, Ltd.
Bibliographie der Flechten und lichenicolen Pilze Mecklenburg‐Vorpommerns von 1996 bis 2006
Authors: Schiefelbein U. , Litterski B. 
Published: August 2007

AbstractIn der Bibliographie sind aus dem Zeitraum von 1996 bis 2006 Publikationen mit Angaben zu Flechten und lichenicolen Pilzen des Bundeslandes Mecklenburg‐Vorpommern erfasst. Aufgeführt ist auch die in der Bibliographie von Litterski (1997c) nicht enthaltene Literatur. In den 63 zitierten Literaturstellen werden 646 Arten angegeben. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Quantification and correction of bias in tagging SNPs caused by insufficient sample size and marker density by means of haplotype‐dropping
Authors: Iles Mark M. 
Published: August 2007

AbstractTagging single nucleotide polymorphisms (tSNPs) are commonly used to capture genetic diversity cost‐effectively. It is important that the efficacy of tSNPs is correctly estimated, otherwise coverage may be inadequate and studies underpowered. Using data simulated under a coalescent model, we show that insufficient sample size can lead to overestimation of tSNP efficacy. Quantifying this we find that even when insufficient marker density is adjusted for, estimates of tSNP efficacy are up to 45% higher than the true values. Even with as many as 100 individuals, estimates of tSNP efficacy may be 9% higher than the true value. We describe a novel method for estimating tSNP efficacy accounting for limited sample size. The method is based on exclusion of haplotypes, incorporating a previous adjustment for insufficient marker density. We show that this method outperforms an existing Bootstrap approach. We compare the efficacy of multimarker and pairwise tSNP selection methods on real data. These confirm our findings with simulated data and suggest that pairwise methods are less sensitive to sample size, but more sensitive to marker density. We conclude that a combination of insufficient sample size and overfitting may cause overestimation of tSNP efficacy and underpowering of studies based on tSNPs. Our novel method corrects much of this bias and is superior to a previous method. However, sample sizes larger than previously suggested may be required for accurate estimation of tSNP efficacy. This has obvious ramifications for tSNP selection both in candidate regions and using HapMap or SNP chips for genomewide studies. Genet. Epidemiol. 31, 2007. © 2007 Wiley‐Liss, Inc.
Missing phenotype data imputation in pedigree data analysis
Authors: Fridley Brooke L. , de Andrade Mariza 
Published: August 2007

AbstractMapping complex traits or phenotypes with small genetic effects, whose phenotypes may be modulated by temporal trends in families are challenging. Detailed and accurate data must be available on families, whether or not the data were collected over time. Missing data complicate matters in pedigree analysis, especially in the case of a longitudinal pedigree analysis. Because most analytical methods developed for the analysis of longitudinal pedigree data require no missing data, the researcher is left with the option of dropping those cases (individuals) with missing data from the analysis or imputing values for the missing data. We present the use of data augmentation within Bayesian polygenic and longitudinal polygenic models to produce k complete datasets. The data augmentation, or imputation step of the Markov chain Monte Carlo, takes into account the observed familial information and the observed subject information available at other time points. These k complete datasets can then be used to fit single time point or longitudinal pedigree models. By producing a set of k complete datasets and thus k sets of parameter estimates, the total variance associated with an estimate can be partitioned into a within‐imputation and a between‐imputation component. The method is illustrated using the Genetic Analysis Workshop simulated data. Genet. Epidemiol. 2007. © 2007 Wiley‐Liss, Inc.
Preoperative radiotherapy and bevacizumab for angiosarcoma of the head and neck: Two case studies
Authors: Koontz Bridget F. , Miles Edward F. , Rubio Mary Ann D. , Madden John F. , Fisher Samuel R. , Scher Richard L. , Brizel David M. 
Published: August 2007

AbstractBackground.Angiosarcoma of the face is a vascular tumor with poor local control and short median survival despite standard treatment. Bevacizumab is a humanized monoclonal antibody to vascular endothelial growth factor (VEGF), which can inhibit tumor growth. It is synergistic with radiotherapy in gastrointestinal malignancies. Given the vascular nature of angiosarcoma and the need for better treatment of this disease, we investigated the concurrent use of bevacizumab with preoperative radiotherapy for head and neck angiosarcoma.Methods.Two patients diagnosed with angiosarcoma of the nose were treated preoperatively with bevacizumab (5–10 mg/kg) and concurrent radiotherapy (50 Gy), followed by resection of the tumor bed.Results.Both patients had a complete pathologic response with no residual disease. Neither has developed recurrence, with follow‐up of 8.5 months and 2.1 years.Conclusions.The neoadjuvant combination of bevacizumab and radiation therapy is promising and should be further studied in the setting of vascular malignancies. © 2007 Wiley Periodicals, Inc. Head Neck 2008
Pediatric mandibular reconstruction using a vascularized fibula flap
Authors: Crosby Melissa A. , Martin Jack W. , Robb Geoffrey L. , Chang David W. 
Published: August 2007

AbstractBackground.The purpose of this study was to address questions concerning the functional outcome following mandibular reconstruction with vascularized fibula flap in skeletally immature childrenMethods.Eleven patients 14 years old or younger who underwent mandibular reconstruction using a free fibula flap were evaluated.Results.The mean follow‐up was 3.4 years. One flap loss occurred and required a second fibula flap. Panorex radiographs showed good bone union and growth in all patients. Functional outcomes were normal according to age in all patients. Two patients had long‐term malocclusion. No patients had to undergo corrective orthognathic surgery. Donor‐site morbidities consisted of great toe flexion contracture (n = 4) and a valgus deformity (n = 1). All patients had a normal gait, and there were no discrepancies in leg lengthConclusion.A mandible reconstructed using a vascularized fibula flap appears to grow accordingly as the child grows, with minimal disturbance to the growth pattern of the midface. © 2007 Wiley Periodicals, Inc. Head Neck 2008
Medical images compression for remote diagnosis using modified SPIHT data organization and fidelity enhancement filter
Authors: Chen Yen‐Yu 
Published: August 2007

AbstractIn this work, an 8 × 8 Discrete Cosine Transform (DCT) approach is adopted to perform DCT shrinkage, followed by modified set partitioning in hierarchical trees (SPIHT) data organization and fidelity enhancement filter for reducing the memory required to store a remote diagnosis and rapidly transmit it. The DCT shrinkage has the ability to retain the detailed characteristics of an image. By means of a simple transformation to gather the DCT spectrum data with the same frequency domain, the DCT shrinkage exploits all the characteristics of individual blocks to a global framework. In this scheme, insignificant DCT coefficients that correspond to the same spatial location in the high‐frequency sub‐bands can be used to reduce the redundancy by a combined function proposed in association with the modified SPIHT. Meanwhile, quad‐tree decomposition and a set of morphological filters for reducing the artifacts are presented. This set of filters employs 8 predefined morphological operations, namely 4 structuring elements (SE), each of which includes both dilation and erosion operations. The voting strategy is used to select the most suitable morphological filter for each block. Simulation results show that the image compression reduced the computational complexity to only a half of the wavelet based sub‐band decomposition and improved the quality of the reconstructed medical image in terms of both the peak signal‐to‐noise ratio (PSNR) and the perceptual results close to JPEG2000 and the original SPIHT at the same bit rate. © 2007 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 17, 49–61, 2007
Binocular imaging of a laser stripe and approximation networks for shape detection
Authors: Muñoz‐Rodríguez J. Apolinar 
Published: August 2007

AbstractA technique for shape detection based on binocular imaging of a laser stripe is presented. In this technique, the object shape is recovered by means of laser stripe projection and binocular imaging. The approach of the binocular imaging in this technique is to avoid stripe occlusions, which appear due to the variation to the object surface. Based on the behavior of the stripe displacement, the object topography is computed by a Bezier approximation network. By means of this network, the measurements of the binocular geometry are avoided. The parameters of the binocular imaging are computed based on the Bezier approximation network. To reconstruct the topography, the object is scanned by a laser stripe. From the scanning, a set of binocular images of the stripe are processed to compute the object dimensions by means of the network. By applying Bezier approximation networks, the performance of the binocular imaging and the accuracy are improved. It is because the errors of the measurement are not added to the computational procedure, which performs the shape reconstruction. This procedure represents a contribution for the stripe projection methods and the binocular imaging. To describe the accuracy a root mean square of error is calculated. This technique is tested with real objects and its experimental results are presented. Also, the time processing is described. © 2007 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 17, 62–74, 2007
Mechanisms of DNA breaks induction in vivo by 5‐azacytidine: paths of micronucleus induction by azaC
Authors: Morales‐Ramírez P. , Vallarino‐Kelly T. , Cruz‐Vallejo V. L. 
Published: August 2007

AbstractThe aim of the present study was to correlate the time‐response curves of micronucleated polychromatic erythrocyte (MN‐PCE) induction by 5‐azacytidine (azaC) with the possible processes involved in DNA break production; this is based on the results previously published by other authors. The MN‐PCE induction at two different doses of azaC was determined by sampling blood from the tails of mice before the acute treatment and over nine periods of 8 h each afterwards. Both doses caused two peaks of MN‐PCE induction, one at 32 h and another at 48 h, approximately; a shoulder was detected that remained high from 56 h up to the end of the study (72 h). These results suggest that azaC induced DNA breaks and subsequently MN (micronucleus) by three different mechanisms, and in agreement with data in the literature, these could be successively the following: (i) during excision of the large adduct comprising the DNA methyl transferase covalently linked to DNA; (ii) failure of recombination repair or mismatch repair; and (iii) persistent chromosome fragility in G‐C rich sites due to DNA demethylation and chromatin decondensation. Copyright © 2007 John Wiley & Sons, Ltd.
Atrazine‐induced changes in aromatase activity in estrogen sensitive target tissues
Authors: Holloway A. C. , Anger D. A. , Crankshaw D. J. , Wu M. , Foster W. G. 
Published: August 2007

AbstractAtrazine (ATR) is a pesticide used widely throughout North America. Although not directly estrogenic, ATR treatment has been shown to increase aromatase activity in tumor cell lines. Thus, it is suggested that ATR can increase local tissue estrogen levels in estrogen sensitive target tissues through increased aromatase activity. Therefore the effect of ATR on aromatase activity was measured in human granulosa‐lutein cell cultures, cells that abundantly express aromatase, and endometrial stromal cell (ESC) cultures, cells that do not express aromatase. Aromatase activity was quantified by the tritiated water method and the specificity of the assay was confirmed by co‐incubation with 4‐hydroxyandrostenedione, an irreversible inhibitor of the catalytic activity of aromatase. Aromatase activity in ATR treated (1–10 µm) granulosa‐lutein cells was increased more than 2‐fold compared with control cultures. There were no treatment related changes in cellular protein and thus it is suggested that the ATR‐induced change in aromatase activity was not due to an increase in cell number. ATR‐treatment had no effect on ESC aromatase activity at any concentration tested. Similarly, there was no effect of ATR treatment on human recombinant aromatase activity in our cell‐free test system. Therefore it is concluded that µm concentrations of ATR can increase aromatase activity of human granulosa cells but not ESC and this effect is not elicited at the enzyme level. Copyright © 2007 John Wiley & Sons, Ltd.
Time course of the change and amelioration of nedaplatin‐induced nephrotoxicity in rats
Authors: Uehara Takeki , Tsuchiya Noriko , Masuda Aki , Torii Mikinori , Nakamura Masuhisa , Yamate Jyoji , Maruyama Toshiyuki 
Published: August 2007

AbstractNedaplatin (NDP) is a second‐generation antineoplastic platinum complex, with reduced nephrotoxicity. Two experiments were conducted to characterize the time course of changes of its nephrotoxicity and to further evaluate whether hydration is useful for amelioration of nephrotoxicity. In the first experiment, 8‐week‐old male rats treated with 6 or 9 mg kg−1 NDP at a single intravenous dose were killed 2, 4, 7 and 14 days after dosing. In the second experiment, nonhydrated (Nhyd) or hydrated (Hyd) rats, treated with a single intravenous dose of 20 mg kg−1 NDP, were killed 7 days after dosing. Besides renal function and histopathological examinations, the urinary excretion of platinum was measured. Histopathologically, NDP‐induced nephrotoxicity was initially characterized by single cell and/or focal necrosis in the epithelium of distal tubules and collecting ducts as well as proximal tubules. In the later stage, subsequent cystic dilatation and regeneration occurred in these affected tubules, but incomplete tissue repair was still observed in the kidney 14 days after dosing. However, NDP‐induced nephrotoxicity was dramatically reduced by hydration, while it had no clear effects on myelotoxicity. Measurement of urinary platinum excretion revealed that the total amount of platinum excretion was significantly higher in Hyd‐NDP rats than that in Nhyd‐NDP rats. In terms of urinary concentration, Hyd‐NDP rats showed a lower concentration compared with that in Nhyd‐NDP rats. The current results suggest that NDP has the potential risk to cause nephrotoxicity at a human therapeutic dose without hydration and that pre‐ and post‐hydration at dosing can ameliorate this nephrotoxicity. Copyright © 2007 John Wiley & Sons, Ltd.