bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, molecular docking analysis, molecular dynamic simulation, ADMET, DFT, and drug likeness studies: Novel Indeno[1,2-b]pyrrol-4(1H)-one as SARS-CoV-2 main protease inhibitors
Authors: Gheidari Davood , Mehrdad Morteza , Bayat Mohammad 
Published: March 2024

Background
The COVID-19 pandemic began in 2019 as a result of the advent of a novel coronavirus, SARS-CoV-2. At present, there are a limited number of approved antiviral agents for the treatment of COVID-19. Remdesivir, Molnupiravir, and Paxlovid have been approved by the FDA to treat COVID-19 infections. Research has shown that the main protease enzyme (Mpro) of SARS-CoV-2 plays a crucial role in the enzymatic processing of viral polyproteins. This makes Mpro an interesting therapeutic target for combating infections caused by emerging coronaviruses.

Methods
The pharmacological effects of pyrroles and their derivatives have a wide range of applications. In our study, we focused on synthesizing nine novel derivatives of 2-arylamino-dihydro-indeno[1,2-b] pyrrol-4(1H)-one, with a particular emphasis on their antiviral properties. Using in silico studies involving molecular docking and DFT analyses in the gas phase using the B3LYP/6-31++G(d,p) basis set, we studied these compounds with respect to their interactions with the Mpro of SARS-CoV-2. The results of the docking analysis revealed that the synthesized compounds exhibited favorable inhibitory effects. Notably, compound 5f demonstrated the highest effectiveness against the target protein. Furthermore, the pharmacokinetic and drug-like properties of the synthesized derivatives of 2-arylamino-dihydroindeno[1,2-b] pyrrol-4(1H)-one indicated their potential as promising candidates for further development as inhibitors targeting SARS-CoV-2. However, it is imperative to determine the in vitro efficacy of these compounds through comprehensive biochemical and structural analyses.
A collostructional approach to Japanese noun-modifying clause construction use and acquisition: a learner corpus study
Authors: De Los Reyes Nicole C. , Römer-Barron Ute 
Published: March 2024

Abstract
Japanese features a general noun-modifying clause construction (NMCC) with a more versatile range of semantic and pragmatic interpretations than equivalent constructions in other languages. Motivated by the learning challenge NMCCs pose to Japanese as a foreign language (JFL) learners, this article examines speech data from the International Corpus of Japanese as a Second Language (I-JAS) to compare learner use of NMCCs against a large L1 Japanese corpus. Instances of the construction from both corpora were analyzed to identify high-frequency part-of-speech categories and subcategories in the modifying clause predicate and head noun slots. A simple collexeme analysis was then employed to identify strongly attracted and repelled lexical items among those identified in realizations of the construction. Taken together, findings from these analyses revealed an important connection between the semantic weight of head nouns in NMCCs and the idiomaticity of the construction, with learner productions demonstrating a tendency toward heavy head nouns. This study lays the groundwork for future research seeking to explore the NMCC at different levels of granularity and to improve its treatment in JFL pedagogical materials.
Does Health Insurance Boost Subjective Well-being? Examining the Link in China through a National Survey
Authors: Wang Chenyang 
Published: March 2024

Abstract
Drawing on nationwide data from the 2021 China General Social Survey, this study leverages ordered logit regression and propensity score matching to delve into the intricate relationship between commercial health insurance and subjective well-being among Chinese residents. The analysis unveils a robust, positive association between commercial health insurance and subjective well-being, with its impact most evident at intermediate levels of happiness. Notably, the study pinpoints a more pronounced effect among the middle-high income group. However, closer scrutiny of the marginal effects reveals a heightened need for commercial health insurance among low-income individuals, suggesting a potential avenue for policy intervention. In light of these findings, we recommend that the Chinese government actively foster the development of commercial health insurance, aligning it effectively with the existing system, to bolster the subjective well-being of the entire population.
Homogeneous ACM and Ulrich bundles on rational homogeneous spaces
Authors: Fang Xinyi 
Published: March 2024

Abstract
In this paper, we characterize homogeneous arithmetically Cohen–Macaulay (ACM) bundles and Ulrich bundles on rational homogeneous spaces.
From this result, we see that there are only finitely many irreducible homogeneous ACM bundles (up to twist) and Ulrich bundles on these varieties. Moreover, we give numerical criteria for some special irreducible homogeneous bundles to be ACM bundles.
Time Scales of the Low-Carbon Transition: A Data-Driven Dynamic Multi-Sector Growth Model
Authors: Vallès Codina Oriol , Semmler Willi 
Published: March 2024

Abstract
This paper employs a dynamic multi-sector growth model with changing technology to study the relevance of the price and quantity dimensions involved in the technical substitution of carbon-intensive technology, that is, the low-carbon transition. For the framing of the transition, the stylized market dynamics by Flaschel and Semmler (1987. “Classical and Neoclassical Competitive Adjustment Processes.” The Manchester School 55 (1): 13–37) are used, who propose a cross-dual out-of-equilibrium adjustment process. The major empirical challenge to identify the adjustment speed for quantities and prices is to empirically estimate sector-specific adjustment coefficients. The transition speed is estimated for seven carbon-intensive sectors in six high-income economies (Germany, France, Italy, Netherlands, Japan, and the US) using a mixed-effects varying-slopes model on EU KLEMS data. Directed technical change is enforced by a revenue-neutral, pro-active fiscal policy of a tax–subsidy form, which has the effect to greatly accelerate the phase-out of carbon-intensive technology and the phase-in of green technology. The speed of green substitution that allows decarbonization is then evaluated analytically and computationally along four policy and time dimensions: cost advantage, a percentage tax on carbon-intensive output, a green subsidy rate, and initial investment ratios. Though the tax itself has an impact on the speed of decarbonization, it is significantly improved by green subsidies and green investments. The cost advantage of the green over the carbon technology is shown to have a negligible impact on decarbonization speed by itself. Without ambitious fiscal policy, especially in the form of green investment support, this substitution process appears to be too slow to reach decarbonization in a timely manner.
I am in the Homeless Home or I Am Always on the Way Home: Formatting Identity and Transcultural Adaptation Through Ethnic and Host Communication
Authors: Chao Chin-Chung , Xie Ming 
Published: March 2024

Abstract
This study uses a phenomenological approach and 25 in-depth interviews to better understand ethnic and host communication by Chinese international students in U.S. higher education and the impact of such communication practices on their cultural identity transformation and transcultural adaptation. The research findings reveal that their ethnic communication reflects their dynamic negotiation of cultural identities and their efforts to integrate their original cultural background and their expectations of others to redefine their own cultural identities and communicative behaviors. It also highlights that Chinese students engage in ethnic communication not only for community building and cultural identity reinforcement but also assertively to express themselves and educate others.
Mathematical analysis of a combustible viscoelastic material in a cylindrical channel taking into account induced electric field: A spectral approach
Authors: Adeosun Adeshina T. , Adesanya Samuel O. , Lebelo Ramoshweu S. , Gbadeyan Jacob A. 
Published: March 2024

Abstract
In spite of the enormous applications of heating combustible materials due to exothermic chemical reactions, scientists and engineers still face a problem with these materials’ tendency to self-ignition, which can result in significant property damage if serious precautions are not taken. Therefore, the thermal decomposition of combustible viscoelastic material in a cylindrical channel is investigated in this study. With a third-order constitutive model considered for viscoelastic flow behavior, momentum and energy-balanced governing equations are provided. The chemical reaction of the material is assumed exothermic and thus follows Arrhenius’s kinetics. A numerical solution is provided for the boundary value problem via the bivariate spectral collocation method, and the impact of kinetics parameters on the combustible viscoelastic material is investigated. Our findings show that self-ignition is delayed with higher values of activation energy parameter (

ε

\varepsilon

) and third-order parameter (

γ

\gamma

), as well as lower values of magnetic field parameter (

M

M

), current density parameter (

δ

\delta

), and electrical conductivity exponent (

m

m

).
Mind the Gap: Comparison of External Load and Load Variation Between a Reserve Team in a 1-Game Week Microcycle and Its First Team in a 2-Game Week Microcycle Within an Elite Professional Soccer Club
Authors: Carpels Thomas , Scobie Nairn , Macfarlane Niall G. , Kemi Ole J. 
Published: March 2024

Abstract
Carpels, T, Scobie, N, Macfarlane, NG, and Kemi, OJ. Mind the gap: comparison of external load and load variation between a reserve team in a 1-game week microcycle and its first team in a 2-game week microcycle within an elite professional soccer club. J Strength Cond Res XX(X): 000–000, 2023—The aim of this study was to quantify and compare weekly external load and within-week load variation of reserve team players (RES) in a 1-game week microcycle to first team players (FT) in a 2-game week microcycle within the same professional soccer club. External load data were collected between 2017 and 2020 for the following parameters: duration, total distance (TD), total high-speed distance (THSD; >19.8 km·h−1), high-speed distance (HSD; 19.8–25.2 km·h−1), sprint distance (SD; >25.2 km·h−1), number of sprints (number of efforts >25.2 km·h−1), number of high-speed efforts (number of HS efforts >19.8 km·h−1), meters per minute (m·min−1), and high-speed meters per minute (HS m·min−1). First team players were subcategorized into starters (ST) and nonstarters (NST). Intergroup differences in cumulative weekly load and weekly load patterns were statistically analyzed, whereas training monotony (TM) was quantified to assess intragroup, within-week, load variation. Reserve team players showed similar weekly loads to ST, apart from significant differences (p < 0.005) in duration (8%), TD (21%), and HS efforts (16%). Similar to ST, RES showed greater values than NST (p < 0.0005) for duration (10%), TD (9%), THSD (30%), HSD (26%), SD (45%), sprints (40%), and HS efforts (22%). Weekly patterns in RES were different from ST and NST (p < 0.05). Training monotony was highest for NST for all parameters, apart from the number of sprints. Reserve team players need to be prepared to cope with cumulative weekly loads and the lack of recovery between games that ST face. However, when RES become NST, effective loading strategies need to be designed within the limits of 2-game week microcycles to ensure continuous development.
Modernizing Urban Food Provisioning: The 1936 Shanghai Fish Market
Authors: Wang Zhengfeng 
Published: March 2024

Abstract
The Shanghai Fish Market (1936), initiated by Republican China’s Ministry of Industry, was briefly a linchpin for producers and distributors, facilitating state intervention in the supply chain of the treaty port city. The market’s modernist design by Su, Yang & Lei Architects departed from the Beaux-Arts-inspired practices often associated with Nationalist China’s self-presentation. Influenced by foreign precedents, it incorporated rationalized trading procedures into its spatial layout. This article examines the market’s construction, which was guided by fishery expertise and aimed to harness natural resources for societal and national benefits. Technopolitical dynamics surrounding the reconfiguration of food provisioning logistics generated power struggles among stakeholders at the local and international levels. Despite the obstacles that constantly challenged the technocrats’ ambition to revolutionize the fishery industry, the Shanghai Fish Market’s historical and architectural significance lies in its efforts to integrate the built and natural environments into a national system of governance.
Presentations and Outcomes Among Infants ≤90 Days With and Without SARS-CoV-2
Authors: Burstein Brett , Sabhaney Vikram , Florin Todd A. , Xie Jianling , Kuppermann Nathan , Freedman Stephen B. ,   Pediatric Emergency Research Network and Pediatric Emergency Research Canada coronavirus disease 2019 study teams
Published: March 2024

OBJECTIVESTo compare symptoms and outcomes among infants aged ≤90 days tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a broad, international sample of emergency departments (EDs).METHODSThis was a secondary analysis of infants aged 0 to 90 days with suspected SARS-CoV-2 infections tested using molecular approaches and with 14-day follow-up. The parent studies were conducted at 41 EDs in 10 countries (the global Pediatric Emergency Research Network; March 2020–June 2021) and 14 EDs across Canada (Pediatric Emergency Research Canada network; August 2020–February 2022). Symptom profiles included presence and number of presenting symptoms. Clinical outcomes included hospitalization, ICU admission, and severe outcomes (a composite of intensive interventions, severe organ impairment, or death).RESULTSAmong 1048 infants tested for SARS-CoV-2, 1007 (96.1%) were symptomatic at presentation and 432 (41.2%) were SARS-CoV-2–positive. A systemic symptom (any of the following: Apnea, drowsiness, irritability, or lethargy) was most common and present in 646 (61.6%) infants, regardless of SARS-CoV-2 status. Although fever and upper respiratory symptoms were more common among SARS-CoV-2–positive infants, dehydration, gastrointestinal, skin, and oral symptoms, and the overall number of presenting symptoms did not differ between groups. Infants with SARS-CoV-2 infections were less likely to be hospitalized (32.9% vs 44.8%; difference −11.9% [95% confidence interval (CI) −17.9% to −6.0%]), require intensive care (1.4% vs 5.0%; difference −3.6% [95% CI −5.7% to −1.6%]), and experience severe outcomes (1.4% vs 5.4%; difference −4.0% [95% CI −6.1% to −1.9%]).CONCLUSIONSSARS-CoV-2 infections may be difficult to differentiate from similar illnesses among the youngest infants but are generally milder. SARS-CoV-2 testing can help inform clinical management.
Monismo prioritario, relaciones internas y libertad modal
Authors: Briceño Sebastián 
Published: March 2024

Schaffer ha argumentado que la prioridad ontológica del cosmos puede ser inferida a partir de la ausencia de la libertad modal de sus partes. En este artículo ofrezco razones en contra de las siguientes premisas de su argumento: (i) el supuesto según el cual los objetos fundamentales gozan de libertad modal, y (ii) el supuesto según el cual los objetos que están en la relación de ser compañeros de mundo, dada la teoría de contrapartidas, carecen de libertad modal.
Hegel, pensador de la escisión: "Principio de apercepción"﻿ como clave de lectura de la introducción a la "Fenomenología del espíritu"
Authors: Castillo Vallez Javier 
Published: March 2024

El presente artículo propone una clave de lectura para entender el rol estructural de saber y verdad, expuesto por Hegel en la introducción de la Fenomenología del espíritu, a partir del principio de apercepción kantiano y la noción de múltiple sin más. Se verá que esto desemboca en una escisión originaria que Hegel primeramente rechaza en el escrito sobre la Diferencia, pero que luego debe suponer en la introducción de la Fenomenología para que este proyecto cobre consistencia.
La dialéctica durante los "años rojos": La matriz de la escisión y la politicidad de la teoría en Alain Badiou
Authors: Filloy Constanza 
Published: March 2024

Este trabajo se centra en la construcción badiouana de la dialéctica y su politicidad durante los llamados “años rojos” (1966-1976). Procuro destacar el carácter político de la dialéctica a partir de una doble hipótesis. En primer lugar, sostendré que la construcción badiouana de la dialéctica otorga una respuesta inmanente y localista al problema de la relación entre la estructura y la historia. En este sentido, organizaré la respuesta de Badiou a dicha problemática a partir de su adopción del principio de la escisión en Teoría del sujeto [1982], para mostrar en qué medida dicha respuesta condensa una serie de desplazamientos inherentes a la dialéctica estructural y la dialéctica histórica en la teoría del sujeto. La segunda hipótesis que desarrollaré es que la propuesta de Badiou permanece en un plano politizante que a su vez restringe la discusión estratégico-política a un ámbito especulativo. Argumentaré que la dialéctica badiouana elabora la relación entre estructura e historia a favor de una subjetividad militante afirmativa, que sería complementada de manera provechosa por un intercambio con la historia efectiva y por un estudio de las luchas emancipadoras.
La estrategia especulativa. Sobre la cuestión ontológica y meta-ontológica en la filosofía de Badiou
Authors: Grasset B. Jean-Paul 
Published: March 2024

Este artículo aborda la reciente actualización de la propuesta filosófica general de Badiou a partir del planteamiento específico de una “estrategia especulativa” en el reciente libro La inmanencia de las verdades. Sostengo la hipótesis de que la idea de una “estrategia especulativa” es un tercer estadio en el proyecto de Badiou denominado “filosofía del acontecimiento”, que cumple y radicaliza los anteriores estadios de “platonismo de lo múltiple” y “comunismo de la Idea”, cuya continuidad descansa en la unidad interna de su proyecto a partir de la ligazón entre su apuesta ontológica y meta-ontológica como filosofía necesariamente sistemática. En primer lugar, mostraré los elementos generales de la filosofía de Badiou explicitando sus etapas y la emergencia de lo que denominaré “filosofía del acontecimiento y del ser múltiple”. En segundo lugar, profundizaré específicamente a partir de la convergencia de la tesis ontológica y meta-ontológica, para caracterizar la apuesta del autor como proyecto sistemático desligado de la ontoteología mediante el recurso especulativo a la matemática para pensar la infinitud. A partir de esto, finalmente, sostendré que la “estrategia” de la obra reciente del autor implica, en términos generales, una especificación del rol de la matemática dentro de su ontología especulativa.
El concepto simondoniano de percepción etológica y el influjo del "apeiron" preplatónico
Authors: Bórquez Zeto 
Published: March 2024

Rastreamos un concepto de “percepción etológica” en Gilbert Simondon asociado a una “etología metaestable” que podría desarticular la diferenciación entre los regímenes de individuación físico y viviente establecida claramente por el filósofo francés en La individuación a la luz de las nociones de forma e información. Nos situamos en el curso El hombre y el objeto (1974-1975), donde aparece una idea de “objeto-organismo” que desencadena dicha problemática. En un segundo momento, indagamos sobre el fundamento preplatónico de lo “preindividual” en La individuación y el énfasis en la noción de apeiron (lo “ilimitado”), pues ello le permite a Simondon plantear una “carga de naturaleza” que se mantiene en las entidades individuadas como resto potencial, lo cual proponemos como clave para interpretar la dimensión “etológica” mencionada en relación con la percepción. Concluimos con algunas proyecciones que profundizan en esta posibilidad a propósito de Protágoras y del “materialismo especulativo” de Quentin Meillassoux.
Terra Incognita. Critical Notes on the Anthropocene
Authors: Doust Dariush 
Published: March 2024

The concept of the Anthropocene, originally proposed by Paul Crutzen and Eugene Stoermer in 2000, denotes the human-dominated geological epoch that follows the earlier Holocene. This article critically investigates productive potentials, ambiguities, and implications of this concept. It starts with the recent past postmodernist notions as a contrasting background and relates the idea of a pending disaster to the scalar differences between earth systems and human literary and artistic practices. Poiesis is the key concept discussed and explained throughout the article. This proposed concept is based on Marx’s idea of the deployment of productive powers (natural or human) as an end in itself. The discussions encompass arts and literature as well as ontological and ethical issues. The main conclusion, presented in the last section, connects the critique of the concept of Anthropocene to the urgency of a collective project based on what I call the principle of sharing.
Le corps vécu n'est pas un corps propre: Beauvoir et l'apparition du corps dans "Le deuxième sexe"
Authors: Lorelle Paula 
Published: March 2024

Dans Le deuxième sexe, Beauvoir affirme que « la femme, comme l’homme, est son corps : mais [que] son corps est autre chose qu’elle ». Apparaît dans cette phrase, comme dans l’histoire de la phénoménologie, l’espace d’une déhiscence au sein du corps vécu. Être son corps n’impliquerait pas que le corps soit entièrement soi – et le corps vécu, dès lors, ne serait plus un corps propre. D’où la question que nous tâcherons ici de déployer : l’aliénation au sein du corps vécu n’est-elle pas la condition même de sa manifestation comme corps matériel ? Nous tâcherons, dans un premier temps, de remonter à la source du concept de « corps propre » (Leib) chez les postkantiens, afin de montrer que le corps n’apparaît comme « propre », dans l’histoire de la philosophie, qu’en disparaissant comme « corps ». Ce qui nous conduira, dans un second temps, à interroger la (ré-) apparition du corps dans Le deuxième sexe, et plus précisément dans la description que Beauvoir fait du cycle menstruel.
Richir, Tarkowskij und die Zone der Affektivität
Authors: Flock Philip 
Published: March 2024

Untersuchungsgegenstand ist ein systematischer Vergleich zwischen Marc Richirs Phänomenologie der Affectivität und Andrej Tarkowskijs Konzeption des Films als lebendiges Zeitbild, illustriert am Beispiel des Werks „Stalker“. Als tertium comparationis dient der Gedanke einer „archaischen“ oder „elementaren“ Affectivität. Eine solche philosophisch-ästhetische Reflexion eröffnet die Möglickkeit, den architektonischen Status klassische Ideen der Philosophie zu prüfen und umzugestalten. Beide Theoretiker behandeln den Gegensatz von Immanenz und Tranzendenz auf eine Weise, die metaphysische Grundstellung von Ich, Welt und Gott unterwandert und durch ein Denken der Schwelle, der Transition oder Transposition ersetzen. Mithilfe Richirs lässt sich die Struktur der „Zone“ als hyperbolisches Phanomen lesen. Erst inmitten seiner Simulacren un Instabilitäten kommt die Humanität al Rätsel zur Erscheinung, d.h., als Selbstreflexivität eines sich bildenden Sinns. Diese Reflexivität phänomenalisiert sich, so die weitere These, diesseits der Unterscheidung von Denken und Fühlen. Der Aufsatz versucht einen Beitrag zur phänomenologischen Ästhetik zu liefern. Mittels Konstellationsanalyse werden in einer ersten Annäherung allgemein-architektonische Isomorphien und Kohärenzen beider Ansätze herausgestellt.