bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Studies of a Super‐Structured Porphyrin Derivative – A Potential Building Block for CcO Mimic Models
Authors: Charalambidis Georgios , Ladomenou Kalliopi , Boitrel Bernard , Coutsolelos Athanassios G. 
Published: January 2009

AbstractA novel porphyrin complex that contains an Fe porphyrin linked to a tridentate ligand where a Cu ion could be coordinated was synthesized. The molecule also incorporated a tyrosine mimic attached to the porphyrin ring via a urea bond and was fully characterized. We studied the action of dioxygen on several porphyrin derivatives electrochemically with a rotating ring‐disk electrode.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
A Concise Synthesis of R‐(–)‐Cicutoxin, a Natural 17‐Carbon Polyenyne
Authors: Gung Benjamin W. , Omollo Ann O. 
Published: January 2009

AbstractA concise synthesis of the natural polyenyne R‐(–)‐cicutoxin (1) is described. After several trials, the successful synthesis commenced with three key fragments, R‐(–)‐1‐hexyn‐3‐ol (8), 1,4‐diiodo‐1,3‐butadiene (9), and THP‐protected 4,6‐heptadiyn‐1‐ol (6). Sonogashira coupling of compound 9 with acetylenes 6 and 8 gave the 17‐carbon frame, which upon regioselective reduction of a triple bond with Red‐Al and removal of the THP protecting group afforded the natural product in four linear steps. The triply convergent synthesis gave R‐(–)‐cicutoxin in 18 % overall yield. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
A Convenient Enantiospecific Route towards Bioactive Merosesquiterpenes by Cationic‐Resin‐Promoted Friedel–Crafts Alkylation with α,β‐Enones
Authors: Alvarez‐Manzaneda Enrique , Chahboun Rachid , Cabrera Eduardo , Alvarez Esteban , Haidour Ali , Ramos Jose Miguel , Alvarez‐Manzaneda Ramón , Tapia Rubén , Es‐Samti Hakima , Fernández Antonio , Barranco Inmaculada 
Published: January 2009

AbstractAn enantiospecific route towards bioactive merosesquiterpenes, based on the cationic‐resin‐promoted Friedel–Crafts alkylation of alkoxyarenes with an α,β‐unsaturated ketone, is reported. Reaction of ketone 11 with 3,4‐methylenedioxyphenol afforded the corresponding chromene. Treatment of 11 with protected phenol 20 gave aryl nordrimane ketone 21, a suitable intermediate in the synthesis of bioactive merosesquiterpenes and their 8‐epi derivatives. By utilizing this methodology, a formal synthesis of (+)‐puupehenone and other related metabolites, via triflate 25, is described. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
AlCl3‐Promoted Facile E‐to‐Z Isomerization Route to (Z)‐2‐Methyl‐1‐buten‐1,4‐ylidene Synthons for Highly Efficient and Selective (Z)‐Isoprenoid Synthesis
Authors: Wang Guangwei , Negishi Ei‐ichi 
Published: January 2009

AbstractZr‐catalyzed methylalumination of 3‐butyn‐1‐ols followed by AlCl3‐promoted stereoisomerization at 50 °C for 6 h provides 4‐iodo‐3‐methyl‐3‐buten‐1‐ols 2b and 6 (≥98 % Z configuration) in 87 and 67 % yields, respectively. (Z)‐1,4‐Diiodo‐2‐methyl‐1‐butene (1b) obtainable by iodination of 2b is a valuable synthon for efficient and selective syntheses of (Z)‐alkene‐containing isoprenoids.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
New Electrochemical Method of Determining Blood and Blood Fractions Antioxidant Activity
Authors: Brainina Kh. Z. , Alyoshina L. V. , Gerasimova E. L. , Kazakov Ya. E. , Ivanova A. V. , Beykin Ya. B. , Belyaeva S. V. , Usatova T. I. , Khodos M. Ya. 
Published: January 2009

AbstractMonitoring of oxidant/antioxidant state (antioxidant activity of blood and blood fractions) is essential for selecting and applying important therapy, to reduce and to prevent oxidative stress and irreversible changes in the body. The paper describes a new potentiometric method of determining antioxidant\oxidant activity (AOA/OA) of blood and blood fractions. The source of information is the electrode potential shift observed when the analyzed sample is introduced into the medium containing a mediator system. Mediator system, measuring electrode, method of blood hemolysis, anticoagulant are chosen. Comparison of the results obtained with the method proposed and the TAS (Randox) method confirms high self‐descriptiveness, and reliability of the results provided by potentiometric method. Relative standard deviation of analysis results, obtained with the use of MPA‐1 instrument and sensor proposed does not exceed 6–10%.
Electrochemical Renewal of Stationary Mercury Drop or Meniscus Electrodes
Authors: Polášková Petra , Novotný Ladislav , Ostatná Veronika , Paleček Emil 
Published: January 2009

AbstractWe show that a liquid mercury drop electrode surface can be electrochemically renewed without mechanical detachment of the drop. Voltammetric experiments with a mechanically renewed stationary (hanging) mercury drop or meniscus electrode (SME) and an electrochemically renewed SME are compared. The measurements were performed with two surface active organic depolarizers, i.e., 2‐aminoanthraquinone and dithiothreitol and surface inactive Cd(NO3)2. The results show that efficient purely electrochemical renewal of the electrode surface of SME for voltammetric purposes is possible.
The Effect of Ionic Liquid Covalent Bonding to Sol‐Gel Processed Film on Ion Accumulation and Transfer
Authors: Lesniewski Adam , Jönsson‐Niedziolka Martin , Niedziolka‐Jönsson Joanna , Rizzi Cécile , Gaillon Laurent , Opallo Marcin 
Published: January 2009

AbstractAccumulation of electroactive anions into a silicate film with covalently bonded room temperature ionic liquid film deposited on an indium tin oxide electrode was studied and compared with an electrode modified with an unconfined room temperature ionic liquid. A thin film containing imidazolium cationic groups was obtained by sol‐gel processing of the ionic liquid precursor 1‐methyl‐3‐(3‐trimethoxysilylpropyl)imidazolium bis(trifluoromethylsulfonyl)imide together with tetramethylorthosilicate on the electrode surface. Profilometry shows that the obtained film is not smooth and its approximate thickness is above 1 μm. It is to some extent permeable for a neutral redox probe – 1,1′‐ferrocene dimethanol. However, it acts as a sponge for electroactive ions like Fe(CN)63−, Fe(CN)64− and IrCl63−. This effect can be traced by cyclic voltammetry down to a concentration equal to 10−7 mol dm−3. Some accumulation of the redox active ions also occurs at the electrode modified with the ionic liquid precursor, but the voltammetric signal is significantly smaller compare with the bare electrode. The electrochemical oxidation of the redox liquid t‐butyloferrocene deposited on silicate confined ionic liquid film is followed by the expulsion of the electrogenerated cation into an aqueous solution. On the other hand, the voltammetry obtained with the electrode modified with t‐butyloferrocene solution in the ionic liquid precursor exhibits anion sensitive voltammetry. This is explained by anion insertion into the unconfined ionic liquid deposit following t‐butylferricinium cation formation.
In vitro genotoxic assessment of xenobiotic diacylglycerols in an in vitro micronucleus assay
Authors: Kayani Mahmood A. , Parry James M. , Vickery Susan , Dodds Peter F. 
Published: January 2009

AbstractXenobiotic diacylglycerols (DG) may induce pathological disorders by causing abnormal chromosomal segregation, which could be aneuploid. In this study, seven xenobiotic‐diacylglycerols (four of drug origin and three of pesticide origin) were evaluated for their ability to induce aneuploidy in mammalian cultures using in vitro cytokinesis blocked micronucleus (CBMN) assay coupled with kinetochore labeling and interphase fluorescent in situ hybridization. Out of seven xeno‐DGs, two (ibuprofen‐DG and fenbufen‐DG) induced statistically significant (P < 0.001) and dose‐dependent increase in micronucleus induction, but this apparent micronucleus induction was very weak in case of fenbufen‐DG. These MN were produced predominantly by aneugenic and clastogenic mechanisms, respectively, confirmed by immunofluorescent labeling of kinetochores. Fluorescent in situ hybridization analysis revealed that ibuprofen‐DG induced significantly higher nondisjunction for chromosomes 10, 17, and 18. Other xenobiotic diacylglycerols (indomethacin‐DG, salicylic acid‐DG, 4‐(2‐methyl‐4‐chlorophenoxy) butanoic acid‐DG (MCPB‐DG), 2‐(2‐methyl‐4‐chlorophenoxy) propanoic acid‐DG (MCPP‐DG) and 2‐(4‐dichlorophenoxy)‐butanoic acid‐DG (2,4 DB‐DG) did not induce micronuclei, but the concentrations tested did not reach levels that caused the marked growth suppression typically required for testing for regulatory testing purposes. However, the levels of growth suppression achieved were similar to that seen with ibuprofen‐DG, which was positive. This study shows that xeno‐DGs, which have been neglected in the past for their possible link to any pathological disorders, need serious assessment of their mutagenic potential. Environ. Mal. Mutagen. 2009. © 2009 Wiley‐Liss, Inc.
The functional neuroanatomy of geriatric depression
Authors: Smith Gwenn S. , Kramer Elisse , Ma Yilong , Kingsley Peter , Dhawan Vijay , Chaly Thomas , Eidelberg David 
Published: January 2009

AbstractObjectivePositron Emission Tomography (PET) studies of cerebral glucose metabolism have demonstrated sensitivity in evaluating the functional neuroanatomy of treatment response variability in depression, as well as in the early detection of functional changes associated with incipient cognitive decline. The evaluation of cerebral glucose metabolism in late life depression may have implications for understanding treatment response variability, as well as evaluating the neurobiological basis of depression in late life as a risk factor for dementia.MethodsSixteen patients with geriatric depression and 13 comparison subjects underwent resting PET studies of cerebral glucose metabolism, as well as magnetic resonance (MR) imaging scans to evaluate brain structure.ResultsCerebral glucose metabolism was elevated in geriatric depressed patients relative to comparison subjects in anterior (right and left superior frontal gyrus) and posterior (precuneus, inferior parietal lobule) cortical regions. Cerebral atrophy (increased cerebrospinal fluid [CSF] and decreased grey and white matter volumes) were observed in some of these regions, as well. Regional cerebral metabolism was positively correlated with severity of depression and anxiety symptoms.ConclusionsIn contrast to decreased metabolism observed in normal aging and neurodegenerative conditions such as Alzheimer's disease, cortical glucose metabolism was increased in geriatric depressed patients relative to demographically matched controls, particularly in brain regions in which cerebral atrophy was observed, which may represent a compensatory response. Copyright © 2009 John Wiley & Sons, Ltd.
Photoinduced isomerization of allyl alcohols to carbonyl compounds using dendrimer disulfide as catalyst
Authors: Tsuboi Takaaki , Takaguchi Yutaka , Tsuboi Sadao 
Published: January 2009

AbstractAllyl alcohols were isomerized to carbonyl compounds using diphenyl disulfide derivatives upon photoirradiation. Especially, dendrimer disulfide catalyzed the isomerization of allyl alcohols. Photoinduced isomerization in water was also succeeded by the use of water‐soluble dendrimer disulfide. © 2009 Wiley Periodicals, Inc. Heteroatom Chem 20:1–11, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20504
Novel synthesis of N,N′‐dialkyl cyclic ureas using sulfur‐assisted carbonylation and oxidation
Authors: Mizuno Takumi , Nakai Takeo , Mihara Masatoshi 
Published: January 2009

AbstractThe first example of cyclic urea synthesis from secondary amines by the use of sulfur‐assisted carbonylation and oxidation was established. By combined sulfur‐assisted carbonylation of secondary α,ω‐diamines under an ambient pressure of carbon monoxide at 20°C with oxidation by molecular oxygen (0.1 MPa, 20°C), a facile synthetic method for N,N′‐dialkyl cyclic ureas including 1,3‐dimethyl‐2‐imidazolidinone was developed. © 2009 Wiley Periodicals, Inc. Heteroatom Chem 20:64–68, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20508
The comparative roles of home and host supervisors in the expatriate experience
Authors: Benson George S. , Pattie Marshall 
Published: January 2009

AbstractThis study investigates the impact of home and host supervisors on expatriate success. Using survey and archival data on 206 expatriates of a large U.S. professional services firm, we hypothesize that high‐quality leader‐member exchange (LMX) relationships with home and host supervisors have different outcomes. Relationships with host‐country supervisors have greater influence on in‐country and short‐term outcomes, including adjustment and intentions to complete the assignment. Home‐country supervisors, on the other hand, have a greater influence over expatriates' subjective fit with their jobs and longer‐term perceptions of how the overseas assignment will impact their career. Using a separate survey of home and host supervisors at the same firm, we found that one reason that home and host supervisors infl uence expatriates differently may be because home supervisors are more likely to see professional development as a goal for expatriate assignments. © 2009 Wiley Periodicals, Inc.
Expatriate practices in German, Japanese, U.K., and U.S. multinational companies: A comparative survey of changes
Authors: Tungli Zsuzsanna , Peiperl Maury 
Published: January 2009

AbstractIn this article we present expatriate management policies and practices of 136 large multinational companies (MNCs) based in four different countries: Germany, Japan, the United Kingdom, and the United States. The findings we focus on include staffing, selection, training, and success. By analyzing our own results as well as comparing them to previous findings, we examine the changes in expatriate practices over time. In the managerial and research implications sections, we share additional findings and our thoughts about future issues and trends in expatriation. © 2009 Wiley Periodicals, Inc.
Evaluation of FEM electric field analysis using the electric properties of giant unilamellar vesicles (GUV) and Jurkat cells measured by electrorotation spectroscopy: Introduction of cryo‐ and lyoprotectants by electrofusion of GUVs and living cells
Authors: Shirakashi Ryo , Reuss Randolph , Schulz Alexander , Sukhorukov Vladimir L. , Zimmermann Ulrich 
Published: January 2009

AbstractElectrofusion of giant unilamellar vesicles (GUVs) and living cells is a gentle method for delivering membrane impermeable cryo‐/lyo‐protective molecules into living cells for cryo‐/lyopreservation. In this method, an optimal length and strength of an electric pulse are required to initiate GUV‐cell fusion. Calculating the electric field by the finite element method (FEM) might be a powerful analytical method for prediction of the optimal pulse length and strength of a deformed and adhered GUV‐cell. The objective of this study is to clarify whether an FEM model of a pulsed GUV or cell could be applicable for prediction of its electric field, especially the change of membrane potential. First, electric properties of GUVs and Jurkat cells were derived from electrorotation spectra with a dipole approximation model. Secondly, the electric field and the membrane potential of a single GUV or cell after applying a stepwise electric field were calculated by an FEM model using the measured electric properties. At the first stage after applying a step electric field, the calculated membrane potential by the FEM model shows good agreement with the membrane potential derived from the dipole approximation model. After complete relaxation of the electric field, the calculated membrane potential of the FEM model is lower than that of the dipole approximation model. This might be because both models do not take into account the effects of electric double layers on both sides of the membrane. © 2009 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/htj.20242
Metazoan origins of DNA replication: Regulation through dynamic chromatin structure
Authors: Rampakakis E. , Arvanitis D.N. , Di Paola D. , Zannis‐Hadjopoulos M. 
Published: January 2009

AbstractDNA replication in eukaryotes is initiated at multiple replication origins distributed over the entire genome, which are normally activated once per cell cycle. Due to the complexity of the metazoan genome, the study of metazoan replication origins and their activity profiles has been less advanced than in simpler genome systems. DNA replication in eukaryotes involves many protein–protein and protein–DNA interactions, occurring in multiple stages. As in prokaryotes, control over the timing and frequency of initiation is exerted at the initiation site. A prerequisite for understanding the regulatory mechanisms of eukaryotic DNA replication is the identification and characterization of the cis‐acting sequences that serve as replication origins and the trans‐acting factors (proteins) that interact with them. Furthermore, in order to understand how DNA replication may become deregulated in malignant cells, the distinguishing features between normal and malignant origins of DNA replication as well as the proteins that interact with them must be determined. Based on advances that were made using simple genome model systems, several proteins involved in DNA replication have been identified. This review summarizes the current findings about metazoan origins of DNA replication and their interacting proteins as well as the role of chromatin structure in their regulation. Furthermore, progress in origin identification and isolation procedures as well as potential mechanisms to inhibit their activation in cancer development and progression are discussed. J. Cell. Biochem. 106: 512–520, 2009. © 2009 Wiley‐Liss, Inc.
Preparation and characterization of poly(lactic‐co‐glycolic acid) microparticles containing DNA molecules encoding a malaria vaccine candidate
Authors: Liu Shan , Danquah Michael K. , Ho Jenny , Ma Charles , Wang Lina , Coppel Ross , Forde Gareth M. 
Published: January 2009

AbstractBACKGROUND: A novel ultrasonic atomization approach for the formulation of biodegradable poly(lactic‐co‐glycolic acid) (PLGA) microparticles of a malaria DNA vaccine is presented. A 40 kHz ultrasonic atomization device was used to create the microparticles from a feedstock containing 5 volumes of 0.5% w/v PLGA in acetone and 1 volume of condensed DNA which was fed at a flow rate of 18 ml h−1. The plasmid DNA vectors encoding a malaria protein were condensed with a cationic polymer before atomization.RESULTS: High levels of gene expression in vitro were observed in COS‐7 cells transfected with condensed DNA at a nitrogen to phosphate (N/P) ratio of 10. At this N/P ratio, the condensed DNA exhibited a monodispersed nanoparticle size (Z‐average diameter of 60.8 nm) and a highly positive zeta potential of 38.8 mV. The microparticle formulations of malaria DNA vaccine were quality assessed and it was shown that the microparticles displayed high encapsulation efficiencies between 82–96% and a narrow size distribution in the range of 0.8–1.9 µm. In vitro release profile revealed that approximately 82% of the DNA was released within 30 days via a predominantly diffusion controlled mass transfer system.CONCLUSIONS: This ultrasonic atomization technique showed excellent particle size reproducibility and displayed potential as an industrially viable approach for the formulation of controlled release particles. Copyright © 2009 Society of Chemical Industry
Pseudoaneurysm of the posterior circumflex humeral artery diagnosed by sonography
Authors: Damgaard Bodil , Court‐Payen Michel , Larsen Lone , Lausten Gunnar 
Published: January 2009

AbstractWe report a rare case of a pseudoaneurysm of the posterior circumflex humeral artery, probably related to a steroid injection in the shoulder 3 months earlier. The clinical presentation was atypical and the location not previously described in the literature. The patient was referred with a painless, nonpulsatile mass in the posterior shoulder region and was suspected of a malignant soft‐tissue tumor. Sonography, including power Doppler imaging, demonstrated a pseudoaneurysm, with the intralesional blood‐filled cavity developed from the posterior circumflex humeral artery. The diagnosis was confirmed by pathologic examination of the surgical specimen. © 2009 Wiley Periodicals, Inc. J Clin Ultrasound, 2009
Cardiac amyloidosis in a patient with multiple myeloma: A case report and review of literature
Authors: Sedaghat David , Zakir Ramzan M. , Choe Jin , Klapholz Marc , Saric Muhamed 
Published: January 2009

AbstractWe report a case of a 52‐year‐old man with multiple myeloma and rapidly progressive heart failure who died unexpectedly from a probable arrhythmia. Postmortem examination revealed infiltrative amyloid cardiomyopathy, a rare cause of predominantly diastolic myocardial disease. Cardiac amyloidosis should be considered in any patient presenting with congestive heart failure, preserved systolic function, and a discrepancy between a low QRS voltage on electrocardiography and an apparent left ventricular hypertrophy on sonogram. The pattern of left ventricular diastolic dysfunction changes during the course of amyloidosis and the classically described restrictive physiology occurs only in advanced stages of the disease. © 2009 Wiley Periodicals, Inc. J Clin Ultrasound, 2009
Reduction of type IIb myosin and IIB fibers in tibialis anterior muscle of mini‐muscle mice from high‐activity lines
Authors: Bilodeau Geneviève M. , Guderley Helga , Joanisse Denis R. , Garland Theodore 
Published: January 2009

AbstractSelective breeding of laboratory house mice (Mus domesticus) for high voluntary wheel running has generated four replicate lines that show an almost threefold increase in daily wheel‐running distances as compared with four nonselected control lines. An unusual hindlimb “mini‐muscle” phenotype (small muscles, increased mitochondrial enzyme levels, disorganized fiber distribution) has increased in frequency in two of the four replicate selected lines. The gene of major effect that accounts for this phenotype is an autosomal recessive that has been mapped to a 2.6335 Mb interval on MMU11, but not yet identified. This study examined the tibialis anterior muscle to determine whether changes in muscle fiber types could explain such modifications in muscle size and properties. Although selected and control lines did not exhibit systematic differences in the fiber types present in the tibialis anterior muscle, as assessed by electrophoresis of myosin heavy chains (MHC) and by histochemistry, mini‐muscle mice lacked type IIB fibers and the corresponding MHCs. Mini‐muscle tibialis show increased activities of hexokinase and citrate synthase compared with the normally sized muscles, likely the result of the modified fiber types in the muscle. The mini‐muscle phenotype is the major means through which selective breeding for high wheel running has modified the functional capacities of the hindlimb muscles, as normally sized tibialis anterior muscles from control and selected lines did not show general differences in their enzymatic capacities, MHC profiles or fiber type composition, with the exception of an elevated hexokinase activity and a reduced GPa activity in the selected lines. J. Exp. Zool. 311A:189–198, 2009. © 2009 Wiley‐Liss, Inc.