bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Flow-through Free Flaps in Head and Neck Reconstruction
Authors: Maier Mark A. , Palines Patrick A. , Guidry Richard F. , Stalder Mark W. 
Published: March 2024

Background:
Reconstructive obstacles in composite head and neck defects are compounded in reoperated, traumatized, irradiated, and vessel-depleted surgical fields. In cases that require multiple free flaps, recipient vessel accessibility and inset logistics become challenging. Strategic flow-through flap configurations mitigate these issues by supplying arterial inflow and venous outflow to a second flap in a contiguous fashion. This approach (1) permits the use of a singular native recipient vessel, (2) increases the reach of the vascular pedicle, avoiding the need for arteriovenous grafting, and (3) allows for a greater three-dimensional flexibility in configuring soft tissue and bony flap inset.

Methods:
To demonstrate this technique, we conducted a retrospective review of all head and neck reconstruction patients presenting to us from March 2019 to April 2021.

Results:
We present seven oncological and two traumatic patients (N = 9) who received flow-through free flaps for head and neck reconstruction. The most common flap used as the flow-through flap was the anterolateral thigh flap (N = 7), followed by the fibula flap (N = 2). Mean follow-up time was 507 days. No flap failures occurred.

Conclusion:
In head and neck reconstruction, the use of the flow-through principle enables uninterrupted vascular flow for two distinct free flaps in single-stage reconstruction for patients with vessel-depleted, irradiated, and/or reoperated fields. We demonstrate that flow-through flaps in the head and neck may be used successfully for a variety of cases and flaps.
Amplitude and Frequency Modulation of EEG Predicts Intraventricular Haemorrhage in Preterm Infants
Authors: Arasteh Emad , Tataranno Maria Luisa , Vos Maarten De , Wang Xiaowan , Benders Manon J.N.L. , Dudink Jeroen , Alderliesten Thomas 
Published: March 2024

AbstractBackgroundIntraventricular hemorrhage (IVH) is a common and significant complication in premature infants. While cranial ultrasound is the golden standard for IVH detection, it may not identify lesions until hours or days after occurring, which limits early intervention. Predicting IVH in premature infants would be highly advantageous. Recent studies have shown that EEG data’s amplitude and frequency modulation features could offer predictive insights for neurological diseases in adults.MethodsTo investigate the association between IVH and EEG monitoring, a retrospective case-control study was conducted in preterm infants. All infants underwent amplitude integrated EEG monitoring for at least 3 days after birth. The study included 20 cases who had an IVH diagnosed on cranial ultrasound and had a negative ultrasound 24h earlier, and 20 matched controls without IVH. Amplitude and frequency modulation features were extracted from single-channel EEG data, and various machine learning algorithms were evaluated to create a predictive model.ResultsCases had an average gestational age and birth weight of 26.4 weeks and 965 grams, respectively. The best-performing algorithm was adaptive boosting. EEG data from 24 hours before IVH detection proved predictive with an area under the receiver operating characteristic curve of 93%, an accuracy of 91%, and a Kappa value of 0.85. The most informative features were the slow varying instantaneous frequency and amplitude in the Delta frequency band.ConclusionAmplitude and frequency modulation features obtained from single-channel EEG signals in extremely preterm infants show promise for predicting IVH occurrence within 24 hours before detection on cranial ultrasound.
Three-Month Interim Analyses of Repeated Low-Level Red-Light Therapy in Myopia Control in Schoolchildren: A Multi-Ethnic Randomized Controlled Trial
Authors: Deen Nellie , Zhu Zhuoting , Qi Ziyi , Aung Yuri Yin-Moe , Bulloch Gabriella , Miao Di , He Mingguang 
Published: March 2024

AbstractPurposeTo assess the efficacy and safety of repeated low-level red-light (RLRL) therapy in controlling myopia progression among multi-ethnic school-aged children. This report focuses on 3-month interim analysis.DesignMulti-ethnic, parallel controlled randomized trialParticipantsA total of 34 children aged 8-13 years with myopia of cycloplegic spherical equivalent (SE) of −0.50 to – 5.00 (inclusive) diopters (D), astigmatism of 2.50 D or less, anisometropia of 1.50 D or less, and monocular best-corrected visual acuity (BCVA) of 20/20 or better were enrolled.MethodsParticipants were randomly assigned to the RLRL group (n = 16) or the single-vision spectacles (SVS) group (n = 18). RLRL therapy was administered twice daily on weekdays for 3-minute sessions, while the SVS group continued routine activities. Assessments were scheduled at baseline and follow-up visits at 1, 3, 6, and 12 months, with compliance monitoring and safety assessments throughout.Main Outcome MeasuresThe primary outcome and a key secondary outcome included axial length (AL) change and cycloplegic spherical equivalent (SE) change.ResultsA total of 31 (91.2%) participated in the 3-month follow-up visit. The RLRL group demonstrated a significant shortening in AL (−0.07 ± 0.07 mm) compared to the SVS group (0.03 ± 0.05 mm, P<0.001). Similarly, SE progression was hyperopic shift in the RLRL group (0.26 ± 0.14 D) while the SVS group exhibited a myopic shift (−0.03 ± 0.38 D, P=0.009). No severe adverse events were reported.ConclusionsThe 3-month interim analysis shows that the efficacy of RLRL therapy in controlling myopia progression among multi-ethnic children is comparable to, or even better than, that idenfied in Chinese patients in previous trials.
Electrical Impedance Spectroscopy Quantifies Skin Barrier Function in Organotypic In Vitro Epidermis Models
Authors: van den Brink N.J.M , Pardow F. , Meesters L.D. , van Vlijmen-Willems I. , Rodijk-Olthuis D. , Niehues H. , Jansen P.A.M. , Roelofs S. H. , Brewer M.G. , van den Bogaard E.H. , Smits J.P.H. 
Published: March 2024

ABSTRACT3 D human epidermal equivalents (HEEs) are a state-of-the-art organotypic culture model in pre– clinical investigative dermatology and regulatory toxicology. Here, we investigated the utility of electrical impedance spectroscopy (EIS) for non–invasive measurement of HEE epidermal barrier function. Our setup comprised a custom–made lid fit with 12 electrode pairs aligned on the standard 24–transwell cell culture system. Serial EIS measurements for seven consecutive days did not impact epidermal morphology and readouts showed comparable trends to HEEs measured only once. We determined two frequency ranges in the resulting impedance spectra: a lower frequency range termed EISdiffcorrelated with keratinocyte terminal differentiation independent of epidermal thickness and a higher frequency range termed EISSCcorrelated withstratum corneumthickness. HEEs generated from CRISPR/Cas9 engineered keratinocytes that lack key differentiation genesFLG,TFAP2A, AHRorCLDN1confirmed that keratinocyte terminal differentiation is the major parameter defining EISdiff. Exposure to pro–inflammatory psoriasis– or atopic dermatitis–associated cytokine cocktails lowered the expression of keratinocyte differentiation markers and reduced EISdiff. This cytokine–associated decrease in EISdiffwas normalized after stimulation with therapeutic molecules. In conclusion, EIS provides a non– invasive system to consecutively and quantitatively assess HEE barrier function and to sensitively and objectively measure barrier development, defects and repair.
A meta-analytic integration of the theory of planned behavior and the value-belief-norm model to predict green consumption
Authors: Jebarajakirthy Charles , Sivapalan Achchuthan , Das Manish , Maseeh Haroon Iqbal , Ashaduzzaman Md , Strong Carolyn , Sangroya Deepak 
Published: March 2024

Purpose
This study aims to integrate the theory of planned behavior (TPB) and the value-belief-norm (VBN) theory into a meta-analytic framework to synthesize green consumption literature.

Design/methodology/approach
By integrating the findings from 173 studies, a meta-analysis was performed adopting several analytical methods: bivariate analysis, moderation analysis and path analysis.

Findings
VBN- and TPB-based psychological factors (adverse consequences, ascribed responsibility, personal norms, subjective norms, attitude and perceived behavioral control) mediate the effects of altruistic, biospheric and egoistic values on green purchase intention. Further, inconsistencies in the proposed relationships are due to cultural factors (i.e. individualism-collectivism, power distance, uncertainty avoidance, masculinity–femininity, short- vs long-term orientation and indulgence-restraint) and countries’ human development status.

Research limitations/implications
The authors selected papers published in English; hence, other relevant papers in this domain published in other languages might have been missed.

Practical implications
The findings are useful to marketers of green offerings in designing strategies, i.e. specific messages, targeting different customers based on countries’ cultural score and human development index, to harvest positive customer responses.

Originality/value
This study is the pioneering attempt to synthesize the TPB- and VBN-based quantitative literature on green consumer behavior to resolve the reported inconsistent findings.
Health care use experiences of ethnoculturally diverse immigrant older adults: a meta-ethnography
Authors: de Witt Lorna , Pfaff Kathryn A. , Reka Roger , Mirza Noeman Ahmad 
Published: March 2024

Purpose
Current and predicted continued dramatic increases in international migration and ethnocultural diversity of older adult cohorts pose challenges for health care services. Review studies on ethnoculturally diverse older adults and health care show a lack of focus on their service use experiences. This study aims to report a meta-ethnography that addresses this knowledge gap through answering the review question: How do ethnoculturally diverse older adults who are immigrants experience health careservices?

Design/methodology/approach
The authors applied a seven-phase method of meta-ethnography to guide the review. The authors conducted two literature searches (April 2018 and June 2020) in MEDLINE, CINAHL, Embase, Sociological Abstracts and Abstracts in Social Gerontology that yielded 17 papers eligible for review.

Findings
“There’s always something positive and something negative” is the overarching metaphor for answering the review question. Findings highlight positive and negative tensions within ethnoculturally diverse older adults’ health care use experiences of understanding and being understood, having trust in providers and the health care system, having needs, preferences and resources met and desire for self-care over dependency. The majority of experiences were negative. Tipping points towards negative experiences included language, fear, provider attitudes and behaviours, service flexibility, attitudes towards Western and traditional health care and having knowledge and resources.

Originality/value
The authors propose concrete actions to mitigate the tipping points. The authors discuss policy recommendations for health care system changes at the micro, meso and macro service levels to promote positive experiences and address mainstream service policy inequities.
Impacts of land use changes on discharge and water quality in rivers and streams: Case study of the continental United States
Authors: Gunawardana Charitha , McDonald Walter 
Published: March 2024

AbstractWater quality trends in streams and rivers are impacted by several factors including land use of the watershed; however, it is unclear what influence changes in the land use of a watershed subsequently have on changes in discharge and water quality in streams and rivers. This study seeks to fill this gap by evaluating the relationship between changes in land use and changes in discharge and water quality at United States Geological Survey (USGS) stream gages over the period of 2008–2016. Using land cover data and discharge and water quality data from 60 USGS gages, regression methods were applied to determine the strength of relationship between land use changes and changes in water quality and quantity. Trends in discharge and water quality were mixed, with a majority of watersheds demonstrating a decrease in dissolved oxygen and turbidity, no overall trend for discharge, and increases in specific conductance. A regression analysis revealed that discharge, turbidity, and specific conductance were correlated with changes in individual land use types with an R2 between 0.12 and 0.25. Combining the influences of multiple land uses in multivariate regression improved the predictions for discharge (R2 0.58) and specific conductance (R2 0.47), highlighting the magnitude for which land cover changes influence trends in water quality. Overall, this study demonstrates the impact that large‐scale land use changes have on surface water quality.
Utility of 30‐day mortality as a quality metric for palliative radiation treatment: A population‐based analysis from Queensland, Australia
Authors: Guan Tracey L , Kutzko Justin H , Lunn Dominic P , Dunn Nathan AM , Burmeister Bryan H , Dadwal Parvati , Tran Nancy , Holt Tanya R 
Published: March 2024

AbstractIntroductionPalliative radiotherapy (PRT) is frequently used to treat symptoms of advanced cancer, however benefits are questionable when life expectancy is limited. The 30‐day mortality rate after PRT is a potential quality indicator, and results from a recent meta‐analysis suggest a benchmark of 16% as an upper limit. In this population‐based study from Queensland, Australia, we examined 30‐day mortality rates following PRT and factors associated with decreased life expectancy.MethodsRetrospective population data from Queensland Oncology Repository was used. Study population data included 22,501 patients diagnosed with an invasive cancer who died from any cause between 2008 and 2017 and had received PRT. Thirty‐day mortality rates were determined from the date of last PRT fraction to date of death. Cox proportional hazards models were used to identify factors independently associated with risk of death within 30 days of PRT.ResultsOverall 30‐day mortality after PRT was 22.2% with decreasing trend in more recent years (P = 0.001). Male (HR = 1.20, 95% CI = 1.13–1.27); receiving 5 or less radiotherapy fractions (HR = 2.97, 95% CI = 2.74–3.22 and HR = 2.17, 95% CI = 2.03–2.32, respectively) and receiving PRT in a private compared to public facility (HR = 1.61, 95% CI = 1.51–1.71) was associated with decreased survival.ConclusionThe 30‐day mortality rate in Queensland following PRT is higher than expected and there is scope to reduce unnecessarily protracted treatment schedules. We encourage other Australian and New Zealand centres to examine and report their own 30‐day mortality rate following PRT and would support collaboration for 30‐day mortality to become a national and international quality metric for radiation oncology centres.
Waxy papules, infiltrated alopecic plaques, and shin ichthyosis
Authors: Bhat Kriti , Madhudiya Rinkal , Elhence Poonam A. , Singh Saurabh 
Published: March 2024

AbstractA 38‐year‐old male presented with waxy papules, plaques over the neck and extremities, and ichthyotic scales over the lower limbs. Skin biopsy revealed a dense medium‐sized lymphocytic infiltrate in the dermis, with perifollicular accentuation and focal exocytosis into the follicular epithelium with strong positivity for CD 3, 4, and 5. Considering the clinicopathological correlation, a diagnosis of follicular mycosis fungoides (FMF) was made. It is a variant of classic mycosis fungoides (MF) where atypical cells invade the follicular epithelium.
The γδ T Cell Club: bringing a global scientific community together in the age of Zoom
Authors: Damani‐Yokota Payal , Eberl Matthias 
Published: March 2024

AbstractImmunologists are very social people—they love to meet other immunologists and talk about immunology (and immunologists). Constantly! γδ T‐cell researchers are no exception. On the contrary, as there are not so many of them compared to, say, researchers working on dendritic cells, they especially crave frequent interactions with like‐minded scientists. This is where the technological solutions being developed during the coronavirus disease 2019 (COVID‐19) pandemic come into play that have, almost overnight, allowed researchers to hold meetings and lectures online. We here describe how we set up the virtual ‘γδ T Cell Club’, a monthly webinar series that aims to bring the field closer together, and present our musings about what we have learned from this experience, which we hope is useful for other researchers interested in connecting online.
Determinants of left atrial local impedance: Relationships with contact force, atrial fibrosis, and rhythm
Authors: Bates Alexander P. , Paisey John , Yue Arthur , Banks Phil , Roberts Paul R. , Ullah Waqas 
Published: March 2024

AbstractIntroductionThe relationships between baseline tissue local impedance (LI), contact force (CF), atrial fibrosis, and atrial rhythm are uninvestigated in a clinical setting. We compared the relationship of LI and CF between atrial fibrillation (AF) and sinus rhythm (SR) accounting for the effects of atrial fibrosis as assessed by bipolar voltage and LI.MethodsPatients undergoing persistent AF ablation were recruited. LI was recorded referenced to patient blood pool (LIr) and concurrent to changes in CF, with data collected at the same locations in AF and SR.ResultsTwenty patients were recruited. 109 locations were sampled obtaining 1903 data points (SR: 966, AF: 937). CF correlated strongly with LI (repeated measures correlation = 0.64). The relationship between CF and LIr was logarithmic. Rhythm and CF had a significant main (both p < .0005) and interaction effect (p = .022) on tissue LI: AF demonstrated higher LIr values than SR for similar CF. Bipolar voltage had no effect on the relationship of CF to LIr in either rhythm. Assessing fibrosis using LIr showed an interaction effect with CF for LIr in SR and AF, (SR: p < .0005, AF: p = .01), with increased fibrosis showing lesser change in LIr per gram of CF.ConclusionsCF and rhythm significantly affect the measured LIr of LA myocardium. Optimal catheter‐tissue coupling may be better achieved with higher levels of CF and in AF rather than SR. Atrial fibrosis, as assessed by LIr but not bipolar voltage, affected the CF–LI relationship.
Nurse and midwife involvement in task‐sharing and telehealth service delivery models in primary care: A scoping review
Authors: Moulton Jessica E. , Botfield Jessica R. , Subasinghe Asvini K. , Withanage Nishadi Nethmini , Mazza Danielle 
Published: March 2024

AbstractAimTo synthesise and map current evidence on nurse and midwife involvement in task‐sharing service delivery, including both face‐to‐face and telehealth models, in primary care.DesignThis scoping review was informed by the Joanna Briggs Institute (JBI) Methodology for Scoping Reviews.Data Source/Review MethodsFive databases (Ovid MEDLINE, Embase, PubMed, CINAHL and Cochrane Library) were searched from inception to 16 January 2024, and articles were screened for inclusion in Covidence by three authors. Findings were mapped according to the research questions and review outcomes such as characteristics of models, health and economic outcomes, and the feasibility and acceptability of nurse‐led models.ResultsOne hundred peer‐reviewed articles (as 99 studies) were deemed eligible for inclusion. Task‐sharing models existed for a range of conditions, particularly diabetes and hypertension. Nurse‐led models allowed nurses to work to the extent of their practice scope, were acceptable to patients and providers, and improved health outcomes. Models can be cost‐effective, and increase system efficiencies with supportive training, clinical set‐up and regulatory systems. Some limitations to telehealth models are described, including technological issues, time burden and concerns around accessibility for patients with lower technological literacy.ConclusionNurse‐led models can improve health, economic and service delivery outcomes in primary care and are acceptable to patients and providers. Appropriate training, funding and regulatory systems are essential for task‐sharing models with nurses to be feasible and effective.ImpactNurse‐led models are one strategy to improve health equity and access; however, there is a scarcity of literature on what these models look like and how they work in the primary care setting. Evidence suggests these models can also improve health outcomes, are perceived to be feasible and acceptable, and can be cost‐effective. Increased utilisation of nurse‐led models should be considered to address health system challenges and improve access to essential primary healthcare services globally.Reporting MethodThis review is reported against the PRISMA‐ScR criteria.Patient or Public ContributionNo patient or public contribution.Protocol registrationThe study protocol is published in BJGP Open (Moulton et al., 2022).
Impact of COPD stage on self management with COPD patients: The mediating role of symptoms management
Authors: Ceyhan Yasemin , Aydin Cihan 
Published: March 2024

AbstractAimsIt is extremely important to determine the relationship between COPD and self‐management (SM) in the disease process. However, the impact of symptom management (SpM) on this relationship is still unclear. The study aimed to examine the mediating role of SpM in the effect of the COPD stage on SM.DesignA predictive correlational study was reported following the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines.MethodsThis study was conducted between 15 February 2023 and 15 June 15 2023, with 306 patients. Data were collected using the Symptom Management Scale for Self‐Efficacy and the Chronic Disease Self‐Management Scale. Descriptive statistics and Process Macro Model 4 in the SPSS program were used for data analysis.ResultsMost of the patients were in the moderate stage of COPD; their SM scores were at low levels; SpM scores were at moderate levels. The model was significant, and the variables explained 65% of the model. The COPD stage was significantly positively correlated with SpM and negatively correlated with SM. There was a significant positive impact between SpM and SM. The positive and significant standardised indirect effect of SpM on SM evidenced a full mediating effect.ConclusionsSymptom management has a full mediating role in the effect of the COPD stage on SM. It was revealed that the level of SM can be increased by achieving SpM.Implications for the Profession and/or Patient CareSymptoms are vital in COPD. Progression of COPD increases symptom severity. Being successful in SpM greatly contributes to the achievement of self‐management. Therefore, nurses should definitely consider symptom control in strengthening self‐management in the care of patients with COPD.Patient or Public ContributionPatients' COPD stage was determined by a pulmonologist involved in the study. Voluntary patients with COPD hospitalised in the pulmonology clinic were included in the study.