bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Forward Head Posture on Neck and Ankle Joint Position Sense: A Cross-Sectional Study
Authors: Abdel-Aziem Amr A. , Mosaad Dalia , Soliman Elsadat S. , Ibrahim Nouran A. 
Published: March 2024

Background: Forward head posture (FHP) decreases the neck position sense and creates tension in the neck muscles, which inversely affects the mechanics of the distal joints through body myofascia. Thus, this study investigated the effects of FHP on neck and ankle joint position sense, and conducted a comparison between the joint position sense of the right and left ankle.
Methods: Fifty-seven subjects were assigned according to the craniovertebral angle (CVA) into the FHP group (CVA <49°; n = 27) or the control group (CVA >49°; n = 30). Head and ankle joint repositioning accuracy was measured by using a cervical range-of-motion device and an isokinetic dynamometer, respectively.
Results: There was a significant increase in the joint position error (JPE) of the cervical flexion, extension, and right and left side bending motions of the FHP group compared to the control group (P < .05). There were significant increases in the JPE of the right and left ankle dorsiflexion and plantarflexion of the FHP group compared to the healthy group (P < .05). Moreover, the JPE of the right ankle dorsiflexion and plantarflexion of the FHP group were significantly higher than the left ankle (P < .05).
Conclusions: The FHP decreases the position sense of cervical flexion, extension, and right and left side bending motions, and the plantarflexion and dorsiflexion of both ankle joints, especially the right ankle joint.
Colon Cancer with Mediastinal Metastasis
Authors: Taleb Imad , Amine Saad Mohammed , Elmhadi Choukri , Tanz Rachid , Errihani Hassan 
Published: March 2024

Background: The patient had a CAF (complete atrial fibrillation) as a comorbidity.
Objective: The most common sites of colon cancer metastasis are the regional lymph nodes, liver, lung, bone and brain.
The patient was 65 years old and had CAF as a comorbidity. She was consulted for a recent dyspnea evolving in a context of altered general state without any digestive sign. A thoracic scan showed a medial mass measuring 53*56*60mm. The lung biopsy revealed a muscular adenocarcinoma of colorectal origin with immunohistochemical expression of cytokeratin 7 (CK7), 20 and cytokeratin (CK) AE1/AE3, CDX2.The Pet Scan confirmed the existence of a hypermetabolic left anterosuperior medial mass in addition to a focal digestive hypermetabolism of the right colonic wall.
A colonoscopy was performed and showed a tumor process in the right colon with a histological and immunohistochemical profile compatible with that of the mediastinal metastasis. The tumor was MSS (microsatellite stable), RAS (rat sarcoma) and BRAF(v-raf murine sarcoma viral oncogene homolog B1)wild type. The patient received a 3-month folfox-panitimumab combination with good tolerance and a partial response of about 50% on the metastasis.
Conclusions: This case report provide a highly unusual instance of colon adenocarcinoma with extensive mediastinal lymph nodes metastasis.
Rheumatology care: Involvement in medical decisions, received information, satisfaction with care, and unmet health care needs in patients with rheumatoid arthritis and ankylosing spondylitis
Authors: Kjeken Ingvild , Dagfinrud Hanne , Mowinckel Petter , Uhlig Till , Kvien Tore K. , Finset Arnstein 
Published: May 2006

AbstractObjectiveTo examine levels of received information, involvement in medical decisions, and satisfaction with care, to explore factors related to current involvement in medical decisions, and to assess patients' unmet health care needs related to their disease.MethodsA total of 1,193 patients with rheumatoid arthritis and ankylosing spondylitis completed self‐reported health status questionnaires, including registration of sociodemographic data and questions about rheumatology care. Separate questions addressed information received, involvement in decisions, and satisfaction with care. Aspects of unmet health were assessed by an open‐ended question.ResultsThe majority of patients reported medium to high levels of received information, involvement in medical decisions, and satisfaction with care. High involvement in medical decisions was univariately associated with high levels of perceived information and satisfaction, as well as with lower age and a good health status. In the multivariate analyses, patient satisfaction (odds ratio [OR] 4.21) and a high level of received information (OR 7.85), age (OR 0.99), and >12 years of formal education (OR 1.46) remained as significant predictors to current involvement. Nearly one‐third reported a variety of unmet health care needs, and this report was associated with poor health.ConclusionThe results indicate a need for a more flexible and patient centered care model, in which patients to a larger degree can decide which services they need and how these services should be delivered.
Electromagnetic and thermal characterization of an UHF‐applicator for concurrent irradiation and high resolution non‐perturbing optical microscopy of cells
Authors: Pickard William F. , Moros Eduardo G. , Cha Bibianna A. , Novak Petr 
Published: May 2006

AbstractTo permit trans‐illuminated, high‐resolution optical microscopy during unperturbed ultrahigh frequency (UHF) irradiation, a novel new class of applicator has been designed based upon a shielded‐pair transmission line. As constructed and tested with water‐immersion optics and air cooling, the applicator works most robustly over 700–1100 MHz and permits SARs at the cell layer as high as 50 W/kg before the steady state temperature rise at the cell‐layer exceeds 0.5 K. Bioelectromagnetics 27:593–601, 2006. © 2006 Wiley‐Liss, Inc.
Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo‐Fc expressing CHO cells cultivated in controlled batch bioreactors
Authors: Trummer Evelyn , Fauland Katharina , Seidinger Silke , Schriebl Kornelia , Lattenmayer Christine , Kunert Renate , Vorauer‐Uhl Karola , Weik Robert , Borth Nicole , Katinger Hermann , Müller Dethardt 
Published: May 2006

AbstractThe impact of process environment changes on process performance is one of the most crucial process safety issues when cultivating mammalian cells in a bioreactor. In contrast, directed shifting of process parameters can also be used as an optimization tool providing higher cell and product yields. Compared to other strategies that also aim on the regulation of cell growth and protein expression process parameter shifts can be easily performed without reagent addition or even genetic modification of the host cell line. However, a successful application of changing process conditions implies a profound understanding of the provoked physiological changes within the cells. In a systematic approach we varied the dissolved oxygen tension (DOT), pH, and temperature of CHO cultures in controlled bioreactors and investigated the impact on growth, productivity, metabolism, product quality and cell cycle distribution using a recombinant CHO cell line expressing the highly glycosylated fusion protein Epo‐Fc. We found the reduction of cultivation temperature and the reduction of (external) pH to exert the most significant effects on process performance by mainly reducing cell growth and metabolism. With respect to the cell line used we identified a set of parameters capable of affecting cell proliferation in favor of an increased specific productivity and total product yield. The well directed alteration of the process environment has emerged as a tool adequate for further process optimization applying a biphasic cultivation strategy. © 2006 Wiley Periodicals, Inc.
An Investigation of the Self‐Assembly of Neutral, Interlaced, Triple‐Stranded Molecular Braids
Authors: Luan Xin‐Jun , Cai Xue‐Hua , Wang Yao‐Yu , Li Dong‐Sheng , Wang Cui‐Juan , Liu Ping , Hu Huai‐Ming , Shi Qi‐Zhen , Peng Shie‐Ming 
Published: May 2006

AbstractThe synthesis and structures of six compounds prepared in two different systems have been explored with the purpose of isolating coordination polymers with interlaced triple‐stranded molecular braid architectures. The dinuclear paddle‐wheel units of [Cu2(maa)4⋅2 H2O] can be rationally tuned to form three classes of isomorphous compounds, namely [Cu2(maa)4(bpp)] (1) (bpp=1,3‐bis(4‐pyridyl)propane, Hmaa=2‐methylacrylic acid), [Cu3(maa)6(bpp)2] (2), and[Cu4(maa)8(bpp)4(H2O)2]⋅2 H2O (3), with a bridging bpp ligand, at controlled ligand‐to‐metal molar ratios, and lead to three coordination polymers having similar one‐dimensional characteristics but different mono‐ and dinuclear nodes. Compound 1, with a bpp:[Cu2(maa)4⋅2 H2O] stoichiometry of 1:1, contains a zigzag chain containing dinuclear nodes, whereas polymer 2, with a bpp:[Cu2(maa)4⋅2 H2O] stoichiometry of 1.5:1, also adopts the topology of a zigzag chain but with both mono‐ and dinuclear nodes. Compound 3, with a bpp:[Cu2(maa)4⋅2 H2O] stoichiometry of 2:1, contains a neutral, interlaced, triple‐stranded molecular braid, which is interwoven by three single‐stranded meso‐helical chains that contain only a mononuclear node. With the three aromatic chelating terminal ligands 2,2′:6′,2′′‐terpyridine (tpy), 1,10‐phenanthroline (phen), and di(2‐pyridyl)amine (dpa) we have also prepared three neutral complexes containing the linear, rigid bridging ligand biphenyl‐4,4′‐dicarboxylate (bpdc), namely [Cd(bpdc)(tpy)]⋅H2O (4), [Cu(bpdc)(phen)2]⋅4.25 H2O (5), and [Cu(bpdc)(dpa)] (6). An infinite meso‐helix is formed initially in 4, and then three of these chains assemble into a triple‐stranded braid similar to that of 3. Complexes 5 and 6 have a mononuclear and a looped dinuclear structure, respectively. Compounds 3 and 4 are unusual examples of triple‐stranded molecular braid coordination frameworks based on different types of co‐ligands.
Electronic and vibrational circular dichroism of aromatic amino acids by density functional theory
Authors: Tanaka Takeyuki , Kodama Takashi S. , Morita Hayato E. , Ohno Takashi 
Published: May 2006

AbstractStructures of model compounds mimicking aromatic amino acid residues in proteins are optimized by density functional theory (DFT), assuming that the main‐chain conformation was a random coil. Excitation energies and dipole and rotational strengths for the optimized structures were calculated based on time‐dependent DFT (TD‐DFT). The electronic circular dichroism (ECD) bands of the models were significantly affected by side‐chain conformations. Hydration models of the aromatic residues were also subjected to TD‐DFT calculations, and the ECD bands of these models were found to be highly perturbed by the hydration of the main‐chain amide groups. In addition to calculating the random‐coil conformation, we also performed TD‐DFT calculations of the aromatic residue models, assuming that the main‐chain conformation was an α‐helix or β‐strand. As expected, the overall feature of the ECD bands was also perturbed by the main‐chain conformations. Moreover, vibrational circular dichroism (VCD) spectra of the hydration models in a random‐coil structure were simulated by DFT, which showed that the VCD spectra are more sensitive to the side‐chain conformations than the ECD spectra. The present results show that analyses combining ECD and VCD spectroscopy and using DFT calculations can elucidate the main‐ and side‐chain conformations of aromatic residues in proteins. Chirality, 2006. © 2006 Wiley‐Liss, Inc.
Deafferentation induces novel axonal projections in the auditory brainstem after hearing onset
Authors: Hsieh Candace Y. , Cramer Karina S. 
Published: May 2006

AbstractDeafferentation of neural tissue can result in cell death, morphological changes, and/or alterations in sources of innervation. These changes often occur during a limited period of development. In the auditory brainstem, the ventral cochlear nucleus (VCN) projects to the contralateral but not ipsilateral medial nucleus of the trapezoid body (MNTB). This pathway is part of a circuit that computes interaural intensity differences used in sound localization. Previous studies have shown that, after the cochlea is removed early in postnatal development, cells in the VCN on the deafferented side die, and the intact VCN innervates MNTB on both sides of the brain. These changes after cochlea removal are limited to an early postnatal period that preceeds hearing onset. In this study, we lesioned the VCN directly to evaluate plasticity in axonal pathways after hearing onset. We found that novel projections from the intact VCN to ipsilateral MNTB emerge after lesions performed as late as postnatal day 25. The morphological sequence of events is similar to that seen during the initial development of this pathway. These data suggest that plasticity in the auditory brainstem is possible when pathways are challenged with denervation of target nuclei. The results show that the opportunity for plasticity in auditory brainstem circuitry is more prolonged than previously thought and that novel pathways can form after the normal pathways are fully mature and functional. Moreover, sensitive periods for changes in individual pathways are independently regulated. J. Comp. Neurol. 497:589–599, 2006. © 2006 Wiley‐Liss, Inc.
The Catalytic Nanodiode: Detecting Continous Electron Flow at Oxide–Metal Interfaces Generated by a Gas‐Phase Exothermic Reaction
Authors: Park Jeong Young , Somorjai Gabor A. 
Published: May 2006

AbstractContinuous flow of ballistic charge carriers is generated by an exothermic chemical reaction and detected using the catalytic metal–semiconductor Schottky diode. We obtained a hot electron current for several hours using two types of catalytic nanodiodes, Pt/TiO2 or Pt/GaN, during carbon monoxide oxidation at pressures of 100 Torr of O2 and 40 Torr of CO at 413–573 K. This result reveals that the chemical energy of an exothermic catalytic reaction is directly converted into hot electrons flux in the catalytic nanodiode. By heating the nanodiodes in He, we could measure the thermoelectric current which is in the opposite direction to the flow of the hot electron current. The chemicurrent is well correlated with the turnover rate of CO oxidation, which is separately measured with gas chromatography. The influence of the flow of hot charge carriers on the chemistry at the oxide–metal interface, and the turnover rate in the chemical reaction are discussed.
Factors affecting stiffness properties in impacted morsellized bone used in revision hip surgery: An experimental in vitro study
Authors: Fosse Lars , Rønningen Helge , Benum Pål , Lydersen Stian , Sandven Rolf B 
Published: May 2006

AbstractWhen revising loosened joint prosthesis, impacted morsellized bone is frequently used as organic scaffolding. We studied the relative influence that different bone particle size, impaction energy, and liquid content had on impacted bone stiffness. Bovine bone was morsellized in a bone mill by three grinding drums to produce bone with different chip size distribution. Next, portions of bone chips of controlled sizes were produced by a five‐leveled sieve. Layer by layer of bone are constructed into pellets by our experimental impaction method. This method allows us to vary one independent factor at a time in a controlled manner while keeping the other factors constant. Stiffness for all bone pellets were measured during impaction and loading. In earlier studies, we focused on how impaction force, number of impaction strokes, and bone liquid contents influence mechanical behavior. Here, we compare the outcome of all studies using general linear models. All five factors significantly contribute to stiffness of impacted morsellized bone. Changing bone moisture has major, while increasing the number of impaction strokes beyond five per layer has minor effect. Low water content is the main contributor to highest load stiffness. Optimal stability of impacted morsellized bone is achieved with dried and well‐graded particles. The number of heavy impaction strokes can be restricted. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006
Multiple copies of coding as well as pseudogene c‐mos sequence exist in three lacertid species
Authors: Pavlicev Mihaela , Mayer Werner 
Published: May 2006

AbstractThe analysis of a 581 bp section of the nuclear gene c‐mos revealed multiple copies of putative functional sequences as well as pseudogenes in three closely related lacertid species Lacerta laevis, L. kulzeri and L. cyanisparsa. A phylogenetic analysis of c‐mos in comparison with a molecular phylogeny based on the mitochondrial cytochrome b gene supports our findings. The study also provides new insights into the phylogenetic relationships of L. cyanisparsa and L. laevis.Pseudogenes of the three species share 11 single‐nucleotide substitutions, a 1 bp deletion and a premature stop codon but differ by group‐specific mutations. This result suggests that the c‐mos gene has become duplicated and subsequently silenced already in the common ancestor of the three species. Sequence divergence suggests that the duplication and the loss of function occurred in the late Miocene/early Pliocene, i.e., about 5 million years ago. Indications of gene conversion are discussed.We suggest that future studies using c‐mos for phylogenetic studies should provide evidence for the orthology of the sequences compared. J. Exp. Zool. (Mol. Dev. Evol.) 306B, 2006. © 2006 Wiley‐Liss, Inc.
Chromotropic acid‐functionalized polyurethane foam: A new sorbent for on‐line preconcentration and determination of cobalt and nickel in lettuce samples
Authors: Azevedo Lemos Valfredo , Novaes Santos Luana , Oliveira Alves Ana Paula , David Graciete Teixeira 
Published: May 2006

AbstractA chromotropic acid‐functionalized polyurethane foam has been developed for use in an on‐line preconcentration system for cobalt and nickel determination. The packing material was prepared by covalent coupling of chromotropic acid with the polyurethane foam through an azo group. Co and Ni ions were sorbed in the minicolumn, from which they could be eluted directly to the nebulizer‐burner system of a flame atomic absorption spectrometer. Elution of cobalt and nickel from the minicolumn can be accomplished with 0.50 and 0.75 M HCl solutions, respectively. The enrichment factors obtained were 22 (Co) and 27 (Ni), for 60 s preconcentration time, and 57 (Co) and 59 (Ni), if a preconcentration time of 180 s was used. Under the optimum conditions, the proposed procedure allowed the determination of metals with detection limits of 0.43 (cobalt) and 0.52 μg/L (nickel), respectively, on using preconcentration periods of 180 s. The accuracy of the developed procedure was evaluated by analysis of the certified reference materials NIST 1515 Apple Leaves and NIST 1570a Spinach Leaves. The method was applied to the analysis of lettuce samples. The contents of cobalt in the samples analyzed varied from 0.75 to 0.98 μg/g. Nickel was not detected in the lettuce samples.
Four decades of joy in mass spectrometry
Authors: Nibbering Nico M.M. 
Published: May 2006

AbstractTremendous developments in mass spectrometry have taken place in the last 40 years. This holds for both the science and the instrumental revolutions in this field. In chemistry the research was heavily focused on organic molecules that upon electron ionization fragmented via complex mechanistic pathways as shown by isotopic labeling experiments. These studies, including ion structure determinations, were performed with use of double focusing mass spectrometers of both conventional and reversed geometry, and equipped with various types of metastable ion scanning and collision‐induced dissociation techniques developed by physical and analytical chemists. Time‐resolved mass spectrometry by use of the field ionization kinetics method, developed by physical chemists, was another powerful way to unravel details of unimolecular gas phase ion dissociations. Then the development of new ionization methods, such as desorption chemical ionization, field desorption, and fast atom bombardment permitted not only to analyze unvolatile, thermally labile and higher molecular weight compounds, but also to study their chemical behavior in the gas phase, initially with use of double focusing instruments and later on with multisector and hybrid mass spectrometers. These ionization methods also enabled to study organometallic compounds and increasingly the field of medium‐sized to large biomolecules, the latter being exploded in the last decade by the development of electrospray‐ and matrix‐assisted laser desorption ionization/time‐of‐flight mass spectrometry. Another area of research concerned the bimolecular chemistry of organic ions with organic molecules in the gas phase. Initially this was performed with use of among others drift‐cell ion cyclotron resonance spectroscopy, that later on was replaced by the developed method of ion trapping and Fourier transform ion cyclotron resonance. Combination of the latter with the afore‐mentioned ionization methods has shifted also in this case the research on organic molecules to organometallic/inorganic systems, and predominantly to biomolecules in the last decade. This invited review will describe the research efforts made by the author's group over the last 40 years together with some personal experiences during his career. © 2006 Wiley Periodicals, Inc.
Exact boundary observability for 1‐D quasilinear wave equations
Authors: Li (Daqian Li) Tatsien 
Published: May 2006

AbstractBy means of a direct and constructive method based on the theory of semi‐global C2 solution, the local exact boundary observability and an implicit duality between the exact boundary controllability and the exact boundary observability are shown for 1‐D quasilinear wave equations with various boundary conditions. Copyright © 2006 John Wiley & Sons, Ltd.
Characterization of the phosphorylation sites of Mycobacterium tuberculosis serine/threonine protein kinases, PknA, PknD, PknE, and PknH by mass spectrometry
Authors: Molle Virginie , Zanella‐Cleon Isabelle , Robin Jean‐Philippe , Mallejac Souen , Cozzone Alain J. , Becchi Michel 
Published: May 2006

AbstractIn Mycobacterium tuberculosis (Mtb), regulatory phosphorylation of proteins at serine and/or threonine residues by serine/threonine protein kinases (STPKs) is an emerging theme connected with the involvement of these enzymes in virulence mechanisms. The identification of phosphorylation sites in proteins provides a powerful tool to study signal transduction pathways and to identify the corresponding interaction networks. Detection of phosphorylated proteins as well as assignment of the phosphorylated sites in STPKs is a major challenge in proteomics since some of these enzymes might be interesting therapeutical targets. Using different strategies to identify phosphorylated residues, we report, in the present work, MS studies of the entire intracellular regions of recombinant protein kinases PknA, PknD, PknE, and PknH from Mtb. The on‐target dephosphorylation/MALDI‐TOF for identification of phosphorylated peptides was used in combination with LC‐ESI/MS/MS for localization of phosphorylation sites. By doing so, seven and nine phosphorylated serine and/or threonine residues were identified as phosphorylation sites in the recombinant intracellular regions of PknA and PknH, respectively. The same technique led also to the identification of seven phosphorylation sites in each of the two recombinant kinases, PknD and PknE.