bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eight‐ and Twelve‐membered Cyclosilazoxanes: Structural Investigation of Two N‐Pentafluorophenyl‐substituted Si4N3O and Si6N2O4 Rings
Authors: Blaurock Steffen , Edelmann Frank T. , Fischer Axel , Haiduc Ionel 
Published: November 2007

AbstractThe molecular structures of two N‐pentafluorophenylcyclosilazoxanes have been investigated. X‐Ray crystal structure determinations of (C6F5)3Me8Si4N3O (2) and (C6F5)2Me12Si6N2O4 (3) revealed the first structurally authenticated examples of eight‐membered Si4N3O and twelve‐membered Si6N2O4 ring systems.
Iatrogenic reflux oesophagitis
Authors: Shepperd H. W. H. 
Published: November 2007

SummaryA report on two patients with severe reflux oesophagitis caused by Emepromium Bromide (‘CETIRPIN’) prescribed for the treatment of urinary symptoms.Emepronium Bromide is a quaternary ammonium anticholinergic drug, which blocks the peripheral cholinergic nerves and ganglionic transmission. In man it increase bladder capacity, delays the first desire to void and decreases voiding pressure.In the last eighteen months two patients have been referred with severe pain on swallowing. The pain was localized behind the sternum and reached down to the epigastrium. On both occasions the symptoms came on rapidly a few days after the treatment was begun. Both patients were on a standard dose of 200 mgs. three times daily. The first patient had had some minor reflux with her last pregnancy thirteen years previously, but otherwise no symptoms suggestive of reflux. The second patient had never has any symptoms suggestive of oesophageal reflux. In both patients a major feature was the severity of their pain.
Laryngeal lupus erythematosus
Authors: Smith Geoffrey A. , Ward Paul H. , Berci George 
Published: November 2007

AbstractTwo cases with laryngeal manifestations of systemic lupus erythematosus presented demonstrate the value of serial indirect laryngeal photography and results of treatment for the mucosal and serosal effects of the disease.Systemic lupus erythematosus is an autoimmune collagen vascular disease which produces widespread damage to connective tissue, blood vessels, serosal surfaces and mucous membranes (Rodman et ah, 1973). It is no surprise that with such a widespread disorder the upper airways too may show involvement.Estimates of the number of patients with laryngeal involvement have ranged from one percent by Dubois (1966) to one-third of patients by other authors (Babich and Tranaov, 1970; Minchinaet al., 1971).Systemic lupus erythematosus may cause laryngeal symptoms referrable to an active mucosal, submucosal or serosal process. With acute flares of the disease, mucosal ulceration, edema, and submucosal hematomas may result in hoarseness and throat pain (Scarpelliet al., 1959). One case of epiglottitis caused by increased mucosal swelling has been reported (Toomeyet al., 1974). As the disease progresses, late effects of mucosal disease including corditis, mucosal thickening, laryngeal scarring with stenosis and laryngitis with dry, thickened vocal cords may appear (Babich and Tramaov, 1970; Smith and Ferguson, 1976). With serosal involvement, the patient may demonstrate perichrondritis, cricoarytenoid arthritis or actual vocal cord paralysis (Dubois, 1966; Montgomery and Lofgren, 1963).Histopathologic study of involved mucosa along with cultures of the tissue is not diagnostic of systemic lupus erythematosus but can help to rule out other disorders similar in appearance such as tuberculosis and rhinoscleroma. Klebsiella rhinoscleromata infections particularly can cause a similar early inflammatory mucosal and late scarred picture.Microscopic sections of mucosa from a patient who died of laryngeal edema secondary to systemic lupus erythematosus appeared similar to mucosa from a patient with subglottic stenosis (Smith and Ferguson, 1976) with an infiltration of histiocytes, lymphocytes, plasma and mast cells.The following two cases demonstrate the differences in the course of serosal and mucosal airways disease.
Effects of tympanic neurectomy on experimentally induced parotid fistulae
Authors: Hashash M. , state F. , Dessouky H. I. 
Published: November 2007

AbstractThe present work was designed to determine whether or not tympanic neurectomy alone could cure parotid fistulae. In six adult dogs parotid fistulae were induced and the tympanic nerve was transected on the right, while the nerve on the left side was left intact as a control. Complete healing of the fistulae on the right side was noticed, while those on the left side persisted. The findings and their significance are discussed.
Vestibular test results related to stimulation intensity
Authors: Norré M. E. 
Published: November 2007

AbstractThe application of several stimulation intensities in vestibular testing leads us to some new considerations about the interpretation of vestibular test results. Indeed, in the ordinary testing procedures, only one stimulation intensity is used. The results thus obtained are considered to reflect the functional capacity of the system examined and are taken to be absolute. However, when we apply different intensities, we can see that in not a negligible number of cases, the results are very different and are related to the intensity applied. On the one hand, this provides some interesting supplementary information about vestibular function which can be expressed in the notions of ‘recruitment’ and ‘decruitment’, or rather of ‘labile’ and ‘stable’ function. On the other hand, as we only use one stimulation intensity in our ordinary tests, we have to be very cautious and to consider their results always in relation to the applied stimulus. We should always remember that, in some cases, the results might be different if we were to apply a different intensity. This is also very important when we compare the results of different authors, using different stimulation techniques.
Chloroquine ototoxicity—a reversible phenomenon?
Authors: Mukherjee D. K. 
Published: November 2007

SummaryA BRIEF review of cranio-facial fibro-osseous lesions is given and 15 cases of fibrous dysplasia and ossifying fibroma are presented with clinical, radiological and histomorphological findings. After histological verification of the fibro-osseous nature of the process, 5 lesions were diagnosed on a radiological basis as fibrous dysplasia exhibiting diffuse (blending) margins, while the diagnosis of ossifying fibroma was given to 10 radiologically sharply-demarcated lesions. Both groups of lesions presented the same histomorphological features, although to a varying degree. Spheroidal calcifications, however, were identified in ossifying fibroma only, but not in all of these. Thus, the differential diagnosis of fibrous dysplasia versus ossifying fibroma rests on a radiological criterion after the histopathologist has verified the fibro-osseous nature of a lesion. The observation times varied from 1 ½ to 34 years. Two cases of fibrous dysplasia and 3 cases of ossifying fibroma recurred. In one case of fibrous dysplasia an osteosarcoma developed 33 years after irradiation. Pain was a, common symptom in the present material.
Juvenile nervus intermedius otalgia
Authors: Sharan R. , Isser D. K. , Narayan H. P. 
Published: November 2007

AbstractAN unusual case of otalgia with severe, piercing, almost constant, shock-like pain localized deep in the ear of a girl of 12 years is described. Clinical examination and investigations failed to demonstrate any organic pathology in the ear, nose, para-nasal sinuses, fauces, pharynx, larynx, teeth, jaws, temporomandibular joint, salivary glands, neck or posterior cranial fossa. Medical treatment and infiltration of local analgesics around the cutaneous nerves brought no relief. The pain was relieved temporarily by chorda tympani neurectomy and permanently by section of the nervus intermedius, thus leading to a diagnosis of nervus intermedius neuralgia.Pain is a warning signal against potential or actual damage to tissue cells. The middle ear is one of those areas which is sensitive to pricking, scratching, cutting, pressure or extremes of heat and cold.Earache is a very common complaint. Pain may be felt in the ear but the cause may lie elsewhere. Such patients with referred otalgia often present to the otologist; rarely, they present with otalgia of neuralgic quality, with piercing, shock-like pain, without any demonstrable or detectable cause in the distribution of the cranial nerves supplying the ear. One such condition is the otological type of geniculate neuralgia, in which the pain is centered within the ear and may radiate to the deeper structures of the face; the attack may be paroxysmal or continuous.The following case of otalgia is reported because of its rarity, its juvenile age of onset, and the problem posed in treatment. The patient was relieved only by surgical treatment.
A double-blind comparative study of Trimethoprim-Polymyxin B versus Trimethoprim-Sulfacetamide-Polymyxin B otic solutions in the treatment of otorrhea
Authors: Gydé Maurice C. 
Published: November 2007

AbstractThis was a double-blind randomized study to compare the safety and efficacy of timethoprim-polymyxin B (TP) and trimethoprim-sulfacetamide-polymyxin B (TSP) drops in the treatment of otorrhea. The 68 cases treated suffered from external otitis, recurrent otitis, recurrent otitis media with tympanic membrance perforation, or infected mastoid cavities and post-operative tympanoplasties. The TP ototopical solution was successful in 60·6 per cent of cases compared to 88·6 per cent of cases with TSP. These rates were statistically different using the Chi Square with Yates' correction method.There were no sings of ototoxicity, fungal infection overgrowth or local sensitivity to either of the solutions.The study has shown that both drugs are equally safe and that TSP is significantly more effective in the treatment of otorrhea.
Middle-ear analysis in the nose/ear distress syndrome
Authors: McNicoll W. D. , Navy Royal 
Published: November 2007

AbstractThe Nose/Ear Distress Syndrome is defined as ‘the combination of nasal septal deformity and eustachian dysfunction in the absence of any other pathology’ (McNicoll and Scanlan, 1979).One hundred and two recruits to the Submarine, Diving and Aircrew branches of the Royal Navy, who at initial assessment had been found to have an intact, immobile tympanic membrane, when the Valsalva, Toynbee or Politzer manoeuvers were performed, were referred to the ORL Department, Royal Navy Hospital, Haslar, for further assessment as to their ability to serve in environments of primarily increased ambient pressure.Forty-two qualified members of the Submarine and Diving Branches acted as controls, and they were known to have positive eustachian function, and also clinically mobile tympanic membranes on performance of the Valsalva manoeuvre.Both groups underwent middle-ear analysis, using a Grason Stadler 1723 Middle-Ear Analyser, which has an additional facility for testing eustachian tube function.Those subjects not in the control group were subjected to an increase in ambient pressure in the compression chamber at HMS Dolphin. The ability to equilibrate an increase in ambient pressure of 10 meters of water was regarded as the ultimate criterion of positive eustachian function, those who were unable to do this were diagnosed as suffering from the Nose/Ear Distress Syndrome.
Chondrosarcoma of the nasal septum
Authors: Bailey C. M. 
Published: November 2007

SummaryThe case history is presented of a patient with a massive chondrosarcoma arising from the posterior part of the nasal septum, extending into the base of the skull to involve the right middle cranial fossa. Removal of the main bulk of the tumour was accomplished by means of a cranio-facial resection, and it is hoped that useful palliation has thus been achieved.The literature relating to this rare tumour is reviewed: only seven cases have been previously described in which the tumour is believed to have arisen from the nasal septum. It is generally accepted that chondrosarcomas are radio-insensitive, and that surgical excision is the only effective form of treatment.
The screening and epidemiology of middle-ear disease in a population of primary school entrants
Authors: Hallett Christopher P. 
Published: November 2007

AbstractThe purpose of this paper is to demonstrate that the epidemiology of middle-ear pathology in primary school entrants is such that any screening procedue based upon a ‘once and for all’ test on a single cohort of children is unlikely to identify those children most in need of intervention and likely to lead to unnecessary over referrals both to a Community Audiology Clinic or a Specialist Unit. Further evidence is produced to show the value of serial tympanometry as a screening tool generally and the use of the tympanometer 85AR specifically. Agreement is also measured between three variables in middle-ear pathology, namely clinical appearance and mobility of the tympanic memebrane and the associated Tympanogram Type. The relative merits of clinical examination as a screen are discussed. A population of children from three primary school was studies on four separate occasions during 1980. 553 five-year-old children were tested overall.
Congenital syphilitic deafness—a further review
Authors: Adams D. A. , Kerr A. G. , Smyth G. D. L. , Cinnamond M. J. 
Published: November 2007

AbstractInitial optimism about the successful outcome of treatment of congenital syphilitic deafness with ampicillin and steroids has always been tempered with an awareness of the uncertain long-term results. This paper is a review of 16 patients treated with various combinations of ampicillin and steroid; these have been followed up for periods of five to 14 years. Ampicillin alone does not prevent progressive hearing loss in the majority of patients. Ampicillin combined with prednisone, or with prednisone and ACTH, has preserved the hearing in all but two ears which had useful hearing before treatment The fact that the hearing in many of these ears, although maintained continues to fluctuate still gives cause for concern.
Severe childhood deafness in Glasgow, 1965–1979
Authors: Flint Ewen F. 
Published: November 2007

AbstractA survey was conducted of deaf children in the Glasgow area diagnosed between 1965 and 1979 to assess the relative incidences of the known aetiological factors. This took the form of a review of case records supplemented by the use of questionnaires. The results showed small variations from earlier published figures but were broadly similar. The effectiveness of rubella and anti-Rhesus immunization were also evaluated. It was found that more than half of all cases of profound deafness in childhood are acquired rather than inherited and are therefore potentially preventable
Ectopic meningioma of the maxillary sinus
Authors: Manni J. J. 
Published: November 2007

AbstractThis paper presents a rare case of meningioma arising in the right maxillary sinus of a 23-year-old Tanzanian male. It appeared as a painless swelling of the right side of the face. The diagnosis was made after histologic examination of the specimen removed by lateral rhinotomy.
Flunarizine in the treatment of vertigo
Authors: Wouters L. , Amery W. , Towse G. 
Published: November 2007

AbstractExperience with flunarizine, a selective calcium-entry blocker, in the treatment of dizziness is reviewed. Clinical efficacy was predicted in pharmacological studies both in rabbits and humans: torsion swing or caloric induced nystagmus were significantly suppressed by flunarizine. Open therapeutic findings, using clinical and electronystagmographic or audiographic assessments as well, showed that flunarizine is of benefit to patients with vertigo of labyrinthine as well as of cerebrovascular origin. These results were confirmed in double-blind controlled trials. Flunarizine, either started with a loading dose gradually decreased thereafter, or given at a fixed 10 mg. dose schedule was proven to produce rapid improvement of dizziness and unsteadiness and to be tolerated very well.
Post-irradiation sarcoma of the lower lip
Authors: Rennie J. S. , McLay A. , Tanner N. S. B. 
Published: November 2007

SummaryThis report records the occurrence of an irradiation induced fibrosarcoma of the lower lip which appears to be the first case documented in this site. The problems associated with the histopathological diagnosis of such lesions are discussed and the value of electonmicroscopical examination of spindle cell sarcomas stressed.
Phonocephalography: a simple, low-cost non-invasive diagnostic technique
Authors: Tewfik Sayed 
Published: November 2007

AbstractThis article presents the phonocephalographic data reported in one case of glomus jugulare tumour, representing local haemodynamic disturbances; and one case with an aortic lesion with pulsating tinnitus, representing systemic haemodynamic disturbances.
Prominent ears: A follow-up study
Authors: Nielsen Frede , Kristensen Søren , Crawford Michael 
Published: November 2007

SummaryFollowing a minimum observation time of 14 months, 74 patients having undergone surgical correction of prominent ears were re-examined. The applied surgical technique was modified from Stenström and Warrer utilizing the scoring technique and subcutaneous matters chrome catgut sutures for fixation. Satisfactory results were achieved in more than 95 percent of the patients. When assesed by both the patient and the surgeon. Only few complications were revealed
Telephone use by a multi-channel cochlear implant patient
Authors: Brown A. M. , Clark G. M. , Dowell R. C. , Martin L. F. A. , Seligman P. M. 
Published: November 2007

AbstractA totally deaf with a multiple-channel cochler prosthesis obtained open-set speech discrimation using the telephone. CID Everyday Sentences were presented by telephone to the patient. Who repeated an average of 21 percent when a repeat of the sentences was permitted. This result is consistent with the patient's reports of telephone usage.
Skin grafting of the anterior stomach wall following pharyngo-gastric anastomosis
Authors: Howard D. J. , Lund Valerie J. 
Published: November 2007

SummaryA simple fast reliable technique for closure of an anterior neck defect is described. The technique involves skin grafting directly onto the serosal layer of the anterior stomach wall following pharyngo-laryngo-oesphagectomy and pharyno-gastric anastomosis.
Histopathology of the stapes in osteogenesis imperfecta
Authors: Pedersen Ulrik , Melsen Flemming , Elbrønd Ole , Charles Peder 
Published: November 2007

SummaryConventional histological studies of stapes footplates from patients with osteogenesis imperfecta revealed, in nine out of 15 stapes examined, an otospongiotic-like lesion. Although the morphology of the stapedial lesion was comparable to the early otosclerotic focus, a greater structural disorganization and larger resorption spaces in osteogenesis imperfecta distinguished the two conditions. The histopathology of the stapes was related to the morphology of cortical and trabecular bone from the iliac crest. Various degrees of immature, osteogenic bony tissue were found in the iliac crest, showing no resemblance to the otospongiotic-like focus in the footplate. Even though the histologic appearance of the stapes footplates differed from the findings in peripheral bone, the present study indicates that the stapedial lesion in osteogenesis imperfecta is most likely a manifestation of the generalized bone and connective tissue disorder. The study further supports the view that osteogenesis imperfecta and otosclerosis are of different aetiology.
Near-total laryngectomy with myo-mucosal valved neoglottis
Authors: Singh Waryam , Hardcastle P. 
Published: November 2007

The entire larynx is usually sacrificed in the process of surgical treatment of T3 glottic carcinoma, trans-glottic carcinoma and pyriform sinus carcinoma, with consequent loss of speech. Most of the uninvolved, cancer-free part of the larynx is discarded for no good reason.According to the surgical principles of oncology, a tumour should be removed with clear margins, but this does not necessarily mean that the whole organ has to be extirpated. In a recently applied surgical procedure, the small tumour-free part of the larynx is fashioned into an innervated myo-mucosal valved shunt joining trachea and pharynx. This neoglottis allows expiration into the pharynx in speech production but it also contracts during swallowing to avoid aspiration. The first four consecutive cases in which this procedure has been carried out with complete success are presented.
Transdermal scopolamine for peripheral vertigo (A double-blind study)
Authors: Rahko T. , Karma P. 
Published: November 2007

AbstractTransdermal scopolamine medication has been evaluated in 30 cases of acute peripheral vertigo. The double blind study revealed favourable effects, e.g. in Menière's disease. The best compromise between effect and side-effects was one active medication patch. The side-effects were those described for scopolamine, such as blurred vision and dryness of the mouth. Transdermal scopolamine seems to offer an alternative form of medication in acute peripheral vertigo.
Fibre optic guided nasal intubation—shouldn'st we be the experts?
Authors: Gleeson M. J. , Stodlak M. Z. , Wengarf C. L. 
Published: November 2007

AbstractDifficult intubations are more common in otolaryngological practice than any other branch of medicine or surgery. The majority of these are predictable. It is the unexpected intubational failure, usually in a patient undergoing treatment for an unrelated problem, that results in tragedy. In this paper the indications for fibre optic guided intubation are discussed, and the technique described and illustrated in a case of pharyngeal obstruction secondary to an epiglottic cyst. It is suggested that our expertise to operate within the upper airway should be exploited to the advantage of our patients, and of our anaesthetic and surgical colleagues.
The role of fibreoptic oesophagogastroscopy in E. N. T. Practice
Authors: Batch A. J. G. 
Published: November 2007

AbstractFibreoptic endoscopy has only recently become used as a diagnostic tool for the E.N.T. surgeon but it has not been widely used in the investigation of pharyngeal disease. During a two-year period at Warwick Hospital 53 patients have undergone flexible fibreoptic endoscopy using a gastroscope, with visualization of the pharynx. larynx and upper G.I. tract as far as the duodenum. This report describes the technique employed, details the endoscopic findings in 53 patients, and discusses the indications for the technique and the advantages that it holds for the E.N.T. surgeon in the diagnosis and management of pharyngeal disease.
Failure of intubation in acute inflammatory airway obstruction in childhood
Authors: Robb Peter J. 
Published: November 2007

SummaryAt the present time, viral laryngotracheobronchitis. (LTB), and bacterial epiglottitis account for the majority of cases of acute infectious upper airway obstruction in children. This airway obstruction may become life-threatening and require relief either by tracheotomy or by nasotracheal intubation. Recently the trend has been away from tracheotomy and towards intubation. Three cases are reported in this paper, in which intubation by experienced anaesthetists proved impossible, and a life-saving tracheotomy was immediately performed by the otolaryngologist in attondance.It is recommended that an experienced otolaryngologist should always be present at the time of intubation, should it prove impossible, and the child require emergency tracheotomy to secure the airway.