bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sheep fed sugarcane-based diets: Insights into productivity, carcass traits, longissimus muscle, and milk quality - A meta-analysis
Authors: Sadarman Sadarman , Nurfitriani Rizki Amalia , Azmi Amirul Faiz Mohd , Nurkholis Nurkholis , Nusantoro Suluh , Respati Adib Norma , Ibrahim Alek , Atmoko Bayu Andri , Sitaresmi Pradita Iustitia , Hudaya Mohammad Firdaus , Sasongko Wahidin Teguh , Baihaqi Zein Ahmad , Hakim Lukman , Jambang Nicolays , Mulianda Randi , Wahyono Teguh , Ujilestari Tri , Sholikin Mohammad Miftakhus 
Published: April 2024

Abstract
This meta-analysis summarizes the effects of incorporating sugarcane or its by-products into the diet of sheep from various aspects including productivity, carcass characteristics, meat quality of the longissimus muscle, and milk quality. Study differences were defined as random factors while fixed factors accounted for the levels of sugarcane supplementation in the sheep diet. The analysis also examined differences in categorical factors such as sugarcane form (whole, top leaves, bagasse, and residue) and pretreatment methods (untreated, hydrolyzed, and ensiled). Adding sugarcane to the sheep diet showed a significant increase in average daily weight gain (ADG) and feed conversion ratio (FCR) (P < 0.05). However, there was a significant decrease in hot carcass weight (HCW), cold carcass weight (CCW), and dressing percentage (DP) (P < 0.05). Color variables, such as redness (a*) and brightness (L*), of sheep meat were higher when fed a sugarcane-based diet provided in the form of whole plant (P< 0.05). Moreover, there was a significant decrease in lactose and protein concentrations in sheep milk (P < 0.05) after feeding a sugarcane-based diet. Overall, sugarcane supplementation showed some benefits in sheep productivity variables, but it did not yield the expected results in maintaining carcass characteristics, longissimus muscle, and milk quality.
Rurality, Cardiovascular Risk Factors, and Early Cardiovascular Disease among Childhood, Adolescent, and Young Adult Cancer Survivors
Authors: Noyd David H. , Bailey Anna , Janitz Amanda , Razzaghi Talayeh , Bouvette Sharon , Beasley William , Baker Ashley , Chen Sixia , Bard David 
Published: April 2024

Abstract
Background and Aims:
Cardiovascular risk factors (CVRFs) later in life potentiate risk for late cardiovascular disease (CVD) from cardiotoxic treatment among survivors. This study evaluated the association of baseline CVRFs and CVD in the early survivorship period.
Methods
This analysis included patients ages 0–29 at initial diagnosis and reported in the institutional cancer registry between 2010 and 2017 (n = 1228). Patients who died within five years (n = 168), those not seen in the oncology clinic (n = 312), and those with CVD within one year of diagnosis (n = 17) were excluded. CVRFs (hypertension, diabetes, dyslipidemia, and obesity) within one year of initial diagnosis, were constructed and extracted from the electronic health record based on discrete observations, ICD9/10 codes, and RxNorm codes for antihypertensives.
Results
Among survivors (n = 731), 10 incident cases (1.4%) of CVD were observed between one year and five years after the initial diagnosis. Public health insurance (p = 0.04) and late effects risk strata (p = 0.01) were positively associated with CVD. Among survivors with public insurance(n = 495), two additional cases of CVD were identified from claims data with an incidence of 2.4%. Survivors from rural areas had a 4.1 times greater risk of CVD compared with survivors from urban areas (95% CI: 1.1–15.3), despite adjustment for late effects risk strata.
Conclusions
Clinically computable phenotypes for CVRFs among survivors through informatics methods were feasible. Although CVRFs were not associated with CVD in the early survivorship period, survivors from rural areas were more likely to develop CVD.
Implications for Survivors:
Survivors from non-urban areas and those with public insurance may be particularly vulnerable to CVD.
The State of the Art Bacterial Nanocellulose: A Scientometric Analysis
Authors: Ferreira Amanda Souza , Rodrigues Heloisa Campeão , de Souza Samara Silva , Ghisi Nédia Castilhos 
Published: April 2024

Abstract
Bacterial nanocellulose (BNC) is a versatile biopolymer with wide-ranging applications in various areas and is responsible for a global market turnover of around US$95 million, with an expected increase to US$3.5 billion by 2026. In view of the relevance and emergence of the subject, there is a need for a systematic analysis of the current state of the art of BNC. The aim of this study is therefore to carry out the first scientometric analysis of bacterial nanocellulose between 2006 and 2024. The study was based on data obtained from the Web of Science (WoS) Main Collection in March 2024, using Topic Search (TS) = bacterial nanocellulose. A total of 1796 documents were obtained, which were refined to 959 documents and analyzed using CiteSpace (5.8.R3) and Excel (2016). As a result of this analysis, the following were obtained: English as the predominant language; the article being the most used type of document; the history of citations and publications steadily increasing from 2013 to 2024. It was possible to correlate the number of publications with investment in nanotechnology, with China and the United States being the countries responsible for the largest number of publications. It was also possible to identify the main trends in the area using keyword analysis. Therefore, with the scientometric analysis carried out, the main influences impacting on the state of the art of bacterial nanocellulose could be verified.
Identification and Description of Emotions by Current Large Language Models
Authors: Patel Suketu , Fan Jin 
Published: April 2024

Abstract

The assertion that artificial intelligence (AI) cannot grasp the complexities of human emotions has been a long-standing debate. However, recent advancements in large language models (LLMs) challenge this notion by demonstrating an increased capacity for understanding and generating human-like text. In this study, we evaluated the empathy levels and the identification and description of emotions by three current language models: Bard, GPT 3.5, and GPT 4. We used the Toronto Alexithymia Scale (TAS-20) and the 60-question Empathy Quotient (EQ-60) questions to prompt these models and score the responses. The models' performance was contrasted with human benchmarks of neurotypical controls and clinical populations. We found that the less sophisticated models (Bard and GPT 3.5) performed inferiorly on TAS-20, aligning close to alexithymia, a condition with significant difficulties in recognizing, expressing, and describing one's or others' experienced emotions. However, GPT 4 achieved performance close to the human level. These results demonstrated that LLMs are comparable in their ability to identify and describe emotions and may be able to surpass humans in their capacity for emotional intelligence. Our novel insights provide alignment research benchmarks and a methodology for aligning AI with human values, leading toward an empathetic AI that mitigates risk.
Phytocytogenotoxicity of Esters obtained from Phenols and Phenoxyacetic Acid using the Steglich reaction
Authors: Pinheiro Patrícia Fontes , Martins Geisiele Silva , Gonçalves Patrícia Martins , Vasconcelos Loren Cristina , Bergamin Aline dos Santos , Scotá Mayla Bessa , Santo Isabella Silva Resende , Pereira Ulisses Alves , Praça-Fontes Milene Miranda 
Published: April 2024

Abstract
There is a growing demand for herbicides that are more effective than conventional ones yet less harmful to ecosystems. Considering this, this study aimed to synthesize esters from phenols and phenoxyacetic acid, using compounds with known phytotoxic potential as starting materials. Phenoxyacetic acid was first synthesized and then utilized in the synthesis of seven esters through Steglich esterification, employing DCC (N,N'-dicyclohexylcarbodiimide) and DMAP (N,N-dimethylpyridin-4-amine) in the presence of phenols (thymol, vanillin, eugenol, carvacrol, guaiacol, p-cresol, and β-naphthol), yielding esters 1–7. All synthesized compounds were characterized using mass spectrometry, as well as 1H and 13C NMR. These compounds were tested for phytotoxicity to evaluate their effects on the germination and root development of sorghum (Sorghum bicolor) and lettuce (Lactuca sativa) seeds, commonly used as model plants in phytotoxicity studies and for the induction of alterations in the mitotic cycle of meristematic cells of L. sativa roots. Esters 1, 3, 4, and 5 exhibited the most significant phytotoxic activity in the initial development stages of both L. sativa and S. bicolor. These findings suggest that these compounds could serve as inspiration for the synthesis of new semi-synthetic herbicides.
Investigation of Anterior Segment and Pupillometry Changes with Sirius Corneal Topography in Chronic Smokers
Authors: Birgul Ramazan , Sakallioglu Ahmet Kursad 
Published: April 2024

Abstract

PurposeChronic smoking is still one of the world’s leading health problems. In addition to the systemic effects of cigarette smoking, ocular effects are also present, as ocular structures are a mucosal surface. The aim of this study was to investigate the effects of chronic cigarette smoking on the anterior segment and pupil using Sirius corneal topography.Materials and MethodsThe study included 70 chronic smokers in the experimental group and 72 non-smokers in the control group. Central corneal thickness (CCT); corneal volume (CV); anterior chamber depth (ACD); anterior chamber angle (ACA); anterior chamber volume (ACV); first non-contact tear breakup time (NCTBUT); mean NCTBUT; meibography; scotopic, mesopic and photopic pupil sizes; and dynamic pupil sizes at 0, 1, 2, 4, 6, 8 and 10 s were measured.ResultsThere were no statistically significant differences between the chronic smoker group and the control group in terms of age; gender; CCT; CV; ACD; ACA; ACV; first NCTBUT; mean NCTBUT; or dynamic pupillometry at 2, 4, 6, 8 and 10 s. There were statistically significant differences between the groups in terms of meibography; scotopic, mesopic and photopic static pupillometry; and dynamic pupillometry at 0 and 1 s.ConclusionIn this study, only the meibomian gland was affected among the anterior segment structures. Changes in other anterior segment structures were not significant. On the pupil, chronic smoking increased the scotopic, mesopic and photopic pupil diameter and the early stages of dynamic pupillometry. This indicates that cigarette smoking results in nicotinic autonomic neuropathy on the pupil.
Green Synthesis of Co-based Nanoparticles from Bean Shell Extract and Determination of the Effect of Their Activity on Sodium Borohydride Hydrolysis
Authors: Baytar Orhan , Şahin Ömer , Genli Nasrettin , Ekinci Arzu 
Published: April 2024

Abstract
The study investigated the effect of Co(0) and Co-B NPs catalysts synthesized using the method of green synthesis on the NaBH4 hydrolysis process. The investigation of the structure and surface morphology of the catalysts was evaluated using XRD, SEM-EDX, TEM, FTIR, and XPS analyses. The effect of catalysts on NaBH4 was examined at different catalyst amounts, different NaBH4/NaOH concentrations, and different temperature values. At 30 °C solution temperature, the highest HGR and TOF values for Co(0) NPs catalyst were determined as 7326 mL.min-1.g-1cat and 8572 mL.min-1.g-1cat, respectively. Under the same conditions, HGR and TOF values for Co-B NPs catalyst were determined as 12524 mL.min-1.g-1cat and 15189 mL.min-1.g-1cat, respectively. The calculated activation energies for Co(0) and Co-B NPs catalysts are 37.68 kJmol-1 and 21.28 kJmol-1, respectively. Enthalpy and entropy values were calculated as 4.43 kJmol-1 and 44 Jmol-1K-1 for Co(0) and 23.16 kJmol-1 and 98 Jmol-1K-1 for Co-B NPs, using Eyring's equation, respectively. The catalysts showed a small decrease in activity over five cycles, indicating that they have potential for reusability.
Enhancing Clinical Spanish Proficiency through Standardized Patient Interactions: A Case Study of Medical Students' Performance
Authors: Vera Alexandra Lopez , Ahmad Joshua , Ramos Catania 
Published: April 2024

Abstract
Background
With the anticipated growth of the Hispanic population in the United States to 30% by 2050, there is an urgent demand for Spanish-speaking healthcare professionals. The California University of Science and Medicine School of Medicine has addressed this need by introducing a medical Spanish curriculum that includes Spanish-speaking Standardized Patients. This innovative educational approach is designed to improve students' communication skills and enhance their ability to take medical histories, preparing them for effective clinical interactions as evaluated through the Objective Structured Clinical Examination.
Methods
This study assesses the impact of the medical Spanish curriculum, with a focus on the role of Standardized Patients in role-playing scenarios that simulate real clinical experiences. A regression analysis was conducted to examine the relationship between students’ attendance in medical Spanish classes and their performance in the Objective Structured Clinical Examination, highlighting the value of experiential learning in developing clinical skills.
Results
The findings indicate a significant positive relationship between consistent participation in medical Spanish courses, which feature Standardized Patient interactions, and higher scores in the Objective Structured Clinical Examination. This relationship emphasizes the importance of regular engagement in these interactive educational settings to improve clinical assessment capabilities.
Conclusions
The inclusion of Standardized Patients in the medical Spanish curriculum plays a critical role in enhancing students’ clinical performance, validating the importance of experiential learning in medical education. This approach confirms the effectiveness of practical, interaction-based language instruction in producing competent, culturally adept healthcare providers ready to serve an increasingly diverse patient demographic.
The implications of Brain-derived neurotrophic factor in the biological activities of platelet-rich plasma.
Authors: Malange Kaue Franco , de Souza Douglas Menezes , Lemes Julia Borges Paes , Fagundes Cecilia Costa , Oliveira Anna Lethicia Lima , Pagliusi Marco Oreste Oreste , Carvalho Nathalia Santos , Nishijima Catarine Massucato , Silva Cintia Rizoli Ruiz da , Consonni Silvio Roberto , Sartori Cesar Renato , Tambeli Claudia Herrera , Parada Carlos Amilcar 
Published: April 2024

Abstract
Platelet-rich plasma (PRP) is a biological blood-derived therapeutic that releases several proteins in injured tissue, regulating the inflammatory process and triggering tissue anabolism. Outside of the central nervous system (CNS), these platelets represent the major source of brain-derived neurotrophic factor (BDNF). The associated anti-inflammatory, antiapoptotic, and antioxidant properties of this neurotrophin could have a potential applicability applied in the pathophysiology of osteoarthritis (OA). In osteoarthritic joints, it is suggested that synovial cells release BDNF, being found higher concentrations of this protein in the patient’s synovial fluid. Thus, considering platelets as an important therapeutic source of BDNF and the potential role of this neurotrophin in regulate joint homeostasis and OA outcomes, this study aimed to evaluate the contribution of BDNF in PRP repair activities on an experimental model of osteoarthritis (EOA) induced by monoiodine acetate (MIA) insult. Initially, the characterization of the PRP was performed, obtaining a leukocyte-poor-platelet-rich plasma (LP-PRP). After, in vitro analysis indicated that platelets activated by Ca2+ release BDNF, and suppression of M1 macrophage polarization induced by LP-PRP is dependent on BDNF-TrkB receptor. The behavioral and ex-vivo analyses in EOA animals showed that functional recovery in gait parameters and mitigation on tissue damage induced by LP-PRP, such as downregulation of inflammatory cytokines (TNF-α), reduction of joint pain and tissue damage (OARSI score and neuronal injury through ATF-3 [+] cells), depends on Trk-B receptor. Thus, the results indicate that BDNF and Trk-B receptor appear to be essential in the mechanisms of joint repair induced by LP-PRP with implications on joint functional recovery as well. These findings contribute to clarifying the role of BDNF in joint homeostasis, repurposing its restricted therapeutic properties in the CNS to repair functions in non-neuronal tissues that could be an option for chronic pain management in osteoarthritis (OA).
Damages and costs of forest wildfires in New Zealand using satellite data
Authors: Blanc Elodie , Noy Ilan 
Published: March 2024

Abstract

We estimate wildfire impacts on Aotearoa New Zealand forests, focusing specifically on impacts in terms of vegetation recovery and costs. To this end, we use satellite-derived imagery of fire intensity and a vegetation index to measure burn severity and vegetation recovery. We then calculate profitability costs and post-fire remediation and clearing costs, estimated under various wildfire intensity scenarios, to determine the total cost of wildfires. We conclude, maybe unsurprisingly, that forests subject to high-intensity fires take longer to recover than those suffering medium- and low-intensity fires. The economic cost is also higher for higher-intensity fires, averaging 18,000 $/Ha, but due to the small relative share of high-intensity fires, it is the medium-intensity fires that cause the most economic damages in New Zealand.
JEL Codes: Q23, Q54
The Development of Indoor Natural Elements Had Relaxing Psychophysiological Effects on Older Adults in Taiwan During the COVID-19 Pandemic
Authors: Chung Ya-Hui , Chen Shiu-Jen , Lee Ching-Lung , Chang Yu-Sen 
Published: March 2024

Abstract

While the COVID-19 pandemic has affected all types of people, older adults have been disproportionately affected. Therefore, during this period we developed an indoor program inspired by art and natural elements (plant essential oils [EOs]) intended to create a relaxing effect akin to a forest atmosphere to enhance their psychophysiological health. There are for 30 Taiwanese older adults (range, 59-79 years) participated in the study. We combined art activity (still-life painting of vegetables) with breathing Pseudotsuga menziesii and Lavandula angustifolia EOs during a 100-minute experiment involving still-life painting and the inhalation of 2.5% diffused EOs. The research shows physiological measures (heart rate, normalized low-frequency heart oscillations, ratio of low- to high-frequency heart oscillations, high-beta waves, and gamma waves) decreased;correspondingly, an increased standard deviation of normal-to-normal intervals, normalized high-frequency heart oscillations, and high-alpha waves were observed, indicating relaxation physiological state. Subjective psychological assessments using the State-Trait Anxiety Inventory–Stateyielded lower post-test scores, further supporting relaxation effects. The psychophysiological data from this study provide important scientific evidence for the physical and mental health benefits of indoor nature-based activity programs for older adults, thereby improving their quality of life.
The natural history and longitudinal outcomes of patients with mild-to-moderate ulcerative proctitis or ulcerative proctosigmoiditis: a single-center, retrospective study
Authors: Ye Kexin , Jin Zhenhe , Chen Qichen , Cen Li , Pan Jiaqi , Zhou Tianyu , Jiang Wenxi , Liu Zhaoxue , Luo Linwen , Shen Zhe 
Published: March 2024

Abstract

Background
Ulcerative proctitis (UP) and ulcerative proctosigmoiditis (UPS) are special forms of ulcerative colitis. The disease burdens of UP and UPS are increasing. However, the natural history and prognosis of patients with mild-to-moderate UP or UPS have been poorly studied.
Aims
The aim of this study is to evaluate the characteristics, short-term and long-term outcomes of patients with mild-to-moderate UP or UPS followed at a single center over a period of 3 years.
Methods
A retrospective study of patients with UP and UPS followed at a single center from 2021 to 2023 was performed. After scanning for inclusion and exclusion criteria, patient demographics and clinical data were collected. Disease severity was accessed by Myao endoscopy scores and ulcerative colitis endoscopic index of severity. Endoscopic improvement was defined as decreased scores at the last follow-up. Disease extension was defined as endoscopic evidence of a greater extent of disease at the last follow-up.
Results
A total of 414 patients were included for evaluation, of which 292 patients (70.53%) were at mild disease stage, and 122 patients (29.47%) had moderate diseases. At the last follow-up, 315 patients (76.09%) showed endoscopic improvement, and 247 patients (59.66%) showed endoscopic remission. An overall extension rate of 11.11% was observed at the last follow-up. Subgroup analysis revealed a better prognosis in younger patients. The disease extension rate was higher in moderate group and symptomatic patients.
Conclusions
Promising outcomes were observed in patients with mild-to-moderate ulcerative proctitis or ulcerative proctosigmoiditis. Disease severity and symptoms are correlated with the risk of extension.