bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vivo response of mouse lymphocytes to phytohemagglutinin and colchicine
Authors: Killen Duncan A. 
Published: February 2007

AbstractThe response of peripheral mononuclear leukocytes and the systemic tolerance of mice to parenterally administered phytohemagglutinin and colchicine were assessed in 200 animals. The administration of 0.5ml of a solution of purified phytohemagglutinin resulted in the appearance of seemingly immature and significantly enlarged (p<0.005) peripheral mononuclear leukocytes. The appearance of large lymphocytes in peripheral blood was interpreted as evidence for the occurrence of lymphoblastic transformation in vivo. However, no blast cells were observed in the peripheral blood smears. The concomitant administration of colchicine prevented enlargement of the circulating mononuclear lymphocytes. The phytohemagglutinin effect was apparently negated or minimized by the concomitant administration of colchicine. The significance of this observation is unknown.
Complete regression of metastases following chemotherapy
Authors: Lawton R. L. , Gulesserian H. P. 
Published: February 2007

AbstractDisseminated solid malignancies are seldom controlled for long periods by the use of chemotherapy. Far‐advanced cancer of the colon has rarely been controlled by the use of chemicals. One of the patients in this report with pulmonary metastases is free of disease at the present time and completely rehabilitated. He received multiple regimens of 5‐fluorouracil but has not received drug for the past 4 years. Long‐term control of metastatic embryonal cell carcinoma of the testicle has been reported, and this 7‐year survival without disease was treated with triple chemotherapy. The causes for these complete regressions are considered.
Pathology of common skin tumors
Authors: Lever Walter F. 
Published: February 2007

AbstractThe clinical and histologic appearance of basal cell epithelioma, squamous cell carcinoma, solar keratosis, leukoplakia, keratoacanthoma, and Bowen's disease is discussed. The association of Bowen's disease with visceral cancer is also mentioned. Several questions and answers are included at the end of the article.
Plastic surgical treatment of facial skin cancer
Authors: Murray Joseph E. , Klein Edmund 
Published: February 2007

AbstractThe principles and application of surgical treatment for skin cancer are outlined. Procedures ranging from simple excision to complex plastic repair are described. The primary aims of providing diagnosis, cure, and maximal retention of function and esthetics are illustrated. Attainment of secondary aims including minimal morbidity and pain, simplicity, and economy of time and expense is discussed. Cancers of the head and neck have been selected for illustrating the fundamentals of surgical treatment for cancer of the skin. These locations are the most common sites of skin cancer and demonstrate the need for combining adequate tumor resection with minimal tissue sacrifice. Selection of specific surgical procedures as optimal therapy is considered as compared to other modalities such as X‐ray therapy, electrocoagulation, and topical chemotherapy. The need for early diagnosis and prompt treatment in order to avoid the development of more serious clinical problems requiring correspondingly more complex procedures is indicated.
Pattern of lymphatic spread in pharyngeal cancer
Authors: Silva Norberto , Shedd Donald P. 
Published: February 2007

AbstractA survey was done on the histologic findings on cleared neck dissection specimens in a group of 42 patients who underwent resection for pharyngeal cancer. Positive nodes were found in 69% of the specimens, with upper deep jugular nodes being most frequently involved and with multiple levels of involvement being found in one quarter of the patients.
Cancer and lipid depletion
Authors: Mays E. Truman 
Published: February 2007

AbstractHyperlipemia developing in tumor‐bearing animals concomitant with depletion of carcass lipid prompted study of human cancers. Gross lipemia when liver function is normal is infrequent in human cancer. Mean serum triglycerides and unesterified fatty acids (UFA) are higher than in normal individuals, but no greater than in patients undergoing severe fat depletion from causes other than cancer. Total plasma fatty acids and cholesterol concentrations in human cancer are normal. An in vivo rat assay for fat‐mobilizing substances in the urine and plasma of cancer patients was negative. The mobilization of carcass lipid in human cancer appears to be in response to an energy deficit created by actively synthesizing tumor tissue. There is no significant difference between nonneoplastic surgery and resective surgery for cancer in regard to mobilization of fat for energy substrates. Even though humans with malignancies deplete their fat stores, they are still able to respond to surgical stress by mobilizing fat from storage depots and transiently elevating plasma UFA.
Leiomyosarcoma of the colon with metastasis to the liver: Right hepatic lobectomy in presence of variant hepatic artery
Authors: Matsuda Takayoshi , Condon Robert E. 
Published: February 2007

AbstractA successful right hepatic lobectomy for a large solitary liver metastasis of a leiomyosarcoma was performed 8 years after removal of the primary lesion in the right colon. An anomalous arterial supply to the medial segment of the left hepatic lobe was encountered during the dissection. Clues to the presence of the anomalous blood supply and the rationale and results of hepatectomy for metastatic neoplasms are discussed briefly. An aggressive approach to surgical therapy is advocated in selected cases.
Mast cells in the estrogen‐induced transplantable renal tumor of the hamster
Authors: Arcadi John A. 
Published: February 2007

AbstractMast cells are frequently seen in and around a variety of malignant tumors. However, mast cells have not been seen in the transplantable estrogen‐induced renal tumor of the hamster. In this study the subcutaneously transplanted renal tumor of Kirkman was examined using a variety of fixation techniques. All tissues were stained in toluidine blue (0.5% solution at a pK of 3.8). Mast cells were seen in great numbers only in tumor tissue frozen in isopentane cooled with liquid nitrogen at −155 C and cut on a cryostat at −20C. This would indicate the importance of the method of preparation of such fastidious cells. The hamster tumor provides, then, an excellent source of mast cells for study in a tumor environment.
Radionuclide imaging devices
Authors: Hardin Virgil M. , Johnston Gerald S. 
Published: February 2007

AbstractThe principal imaging devices used in clinical and research medicine are mentioned with a more detailed discussion of the instruments used in clinical practice and the modified devices presently in operation at Donner Laboratories. Radionuclide imaging techniques have become remarkably sophisticated since the first mechanical scanner was introduced 20 years ago. Today, high‐resolution scintigrams can be produced in minutes, and sequential images, each requiring only a few seconds, provide data on blood flow distribution and organ function. Tomographic imaging has further extended the capability and reliability of organ imaging.
The use of radionuclides in the detection of bone metastases
Authors: Verdon Thomas A. , Yano Yukio , Anger Hal O. 
Published: February 2007

AbstractBone imaging is a valuable procedure in the evaluation of patients suspected of having metastatic disease to bone. Its use has been well established in many clinical studies. Several radionuclides are available that can detect the presence of metastatic disease before X‐ray changes occur. Because other nonmalignant conditions may produce positive bone scans, the procedure must be used in conjunction with the appropriate X‐ray and other diagnostic studies. Fluorine‐18 approaches the ideal bone‐imaging radionuclide. As it becomes more available commercially, fluorine‐18 will probably replace strontium‐85 as the main radionuclide for bone imaging. Although fluorine‐18 bone imaging with a whole body scanner and the positron camera affords a most optimal combination, the use of strontium‐85 with conventional imaging equipment provides the physician with important clinical information that cannot be obtained by other studies.
Ovarian carcinoma in California: The California tumor registry data
Authors: Krain L. S. 
Published: February 2007

AbstractAppropriate data from the California and Alameda County Tumor Registries were analyzed with specific reference to ovarian cancer (I.C.D. No. 175). The median age for ovarian cancer cases (1942–1969) was 56.7 years. There was a direct association of the age‐adjusted death rate and average annual incidence rate of ovarian cancer patients and the presence of a high socioeconomic ranking (r = + 0.37) (p < 0.05). There was a positive association of ovarian cancer incidence with the census tract index of crowding per household. An excess of ovarian cancer deaths was noted in the Spanish surname population (p < 0.05). Further follow‐up studies are suggested for this disease which has a five‐year relative survival rate for all stages in California of 33%.
Urinary chemiluminescence in women receiving oral contraceptives
Authors: Silk Mark , Sigman Eugene 
Published: February 2007

AbstractUrinary tryptophan metabolites have been associated with the development of uroepithelial neoplasia. Tryptophan metabolites are increased in women receiving oral contraceptives (OC). Urinary chemiluminescence (CHL) may be related to the carcinogenesis of tryptophan metabolites and appear to be elevated in women receiving OC. This may theoretically impose an increased risk of developing uroepithelial neoplasia in women receiving OC.
Villous adenoma of the colon and rectum
Authors: Evans James T. , Imahori Schira , Liu Kuochin 
Published: February 2007

AbstractOne hundred and four cases of villous tumors during a 19‐year period are reported, including 38 cases of villous adenoma and 40 cases of carcinoma arising in villous adenoma. These tumors are found in the rectum and rectosigmoid of patients who are mostly 50 years old or older. The majority of these tumors are malignant and the accuracy of diagnosis by biopsy is rather low. Villous tumors of the colon and rectum should be treated as cancerous growths, and radical resection is the preferred treatment.
Value of renography following radical pelvic cancer surgery
Authors: Soloway Mark S. , Larson Steven M. , Myers George H. , Johnston Gerald S. , Ketcham Alfred S. 
Published: February 2007

AbstractSeveral cases are presented to illustrate how the radioisotope renogram has become an important adjunct in the postoperative evaluation of cancer patients requiring ileal conduit urinary diversion. The use of the renogram in the immediate postoperative period is best exemplified by its ability to aid in differentiating between the causes of oliguria. The sensitivity of the renogram in detecting urinary tract obstruction makes it particularly valuable in the long term management of these patients, whose urinary tract is in constant jeopardy, since it is safer and more convenient than commonly employed radiographic procedures.
Continuous, simultaneous and instantaneous tissue gas and blood flow measurements using the mass spectrometer
Authors: Owens Guy , Roberts Melville 
Published: February 2007

AbstractUsing a membrane permeable to gases it has been demonstrated in our laboratory that partial pressures of O2, CO2 and N2 can be monitored continuously, simultaneously and instantaneously employing a mass spectrometer. Physiologic studies in experimental animals have been carried out recording tissue gases from kidney, liver, skin and brain. Responses in these organs to changes in blood flow, blood gases, surgical trauma, and isolated perfusion have been conducted. Blood flow can be calculated by adding an inert gas (Argon) to the ventilation mixture, and recording its washout time. Simultaneous pO2, pCO2 and PAr permits focal metabolic studies previously impossible to record.
A murine polycythemic virus and its possible role in the study of human leukemia etiology
Authors: Mirand E. A. 
Published: February 2007

AbstractA murine polycythemic virus (FV‐P) has been described that induces a rapid polycythemia in susceptible mice within three weeks postinfection. The hypervolemic polycythemia response is essentially spleen dependent. FV‐P also induces spleen focus formation on the surfaces of the spleens of infected mice nine days after I.V. inoculation of the virus. Recent studies have shown that FV‐P requires a helper virus in order to produce spleen focus formation and polycythemia. The helper virus was found to be indigenous in FV‐P preparations and is a lymphatic leukemia virus (LLV). The indigenous helper virus can be removed from FV‐P preparations and substituted by other RNA leukemic viruses from a number of species‐mice, birds, and cats. Helper activity was also found in tissue culture extracts of human leukemic spleens. Because these human extracts had the same helper activity as shown for RNA leukemic viruses from other species, there is good basis to believe that FV‐P could be useful in providing a biological assay system for the detection of a human leukemic virus.
Pathology of liver necrosis and regeneration after administration of dimethylnitrosamine in massive doses
Authors: Kuster Gustavo G. R. , Woods John E. , Ludwig Jurgen 
Published: February 2007

AbstractTwo groups of dogs were given dimethylnitrosamine (DMNA), a hepatotoxic drug, in a single lethal dose. Control dogs were allowed to die. Experimental dogs received life‐saving auxiliary liver transplants which were removed after recovery of the host liver or when rejection occurred. The histopathologic findings in the host livers of the two groups are presented. Remarkable variations were noted even among livers from the same group. Centrilobular and midzonal congestion and necrosis were the main findings but appeared less severe than one would expect in view of the lethality of DMNA in control dogs. In contrast to the changes noted with long‐term administration of the drug to dogs, there was nothing in this series to suggest cirrhosis.
Augmentation of immune activity by elimination of antibody and its implications in cancer
Authors: Rose Sam 
Published: February 2007

AbstractA “procedure” consisting of thoracic duct fistula, intravenous return of cells, wasting lymph fluid, and administration of replacement therapy was performed on rats immunized with SRBC or nucleated cells from histo‐incompatible donors. The “procedure” resulted in a large augmentation of the homoral immune response described by the following parameters. The number of 19S antibody‐producing cells in spleen and lumph nodes increased up to twenty‐fold. The daily antibody content in the lymph increased exponentially, doubling every 10 to 18 hours, and reached peak values of 100 times the antibody content in the whole animal prior to fistula. The peak antibody production rate of experimental animals was 1000 times the pre‐fistula level—this latter rate being the antibody production level in animals with a stable immunity. The immune augmentation which was achieved in these experimentds does not represent the therorectical or practical limit attainable. When the “procedure” was performed in nonsplenectomized animals without raised venous pressure, the blood liter fell and then rose to pre‐fistula levels or higher, and the daily antibody content of the lymph samples reached a platueau. When the “procedure” was performed in splenectomized animals with raised venous pressure the blood liter fell and remained low and there was a continuing exponential increase in antibody contenl of progressive lymph samples throughout the duration of the fistula procedure. The “procedure” and results are discussed in relation to aspects of immune regulation and practical advantages for antibody production. The implications of the “procedure” as a means of manipulating components important in tumor‐host immune relationship are discussed with respect to possible immunotherapy of cancer. The “procedure” caused regression of M. S. V. induced tumors growing in syngeneic rats. It is suggested that the effect on the tumors was due to the mechanisms discussed.
Some biochemical and histochemical aspects in hyperplasia and carcinoma of the human prostate
Authors: Nilsson T. , Müntzing J. 
Published: February 2007

AbstractA study of histochemical and biochemical enzyme activity determination in hyperplastic and untreated carcinomatous prostatic tissue is presented. The histochemical results are in agreement with earlier investigations and the biochemical findings corroborate grossly the histochemical findings. A comparison of conventional estrogen therapy to Estramustine phosphate, (EstracytR), therapy is discussed from both the histochemical and biochemical points of view. The enzyme activity quotient, acid phosphatase to β‐glucuronidase, is pointed out as a possible indicator in following the therapeutic response, and in determination of the origin of metastases. Lipofuscin pigment is demonstrated to a much higher frequency after Estracyt treatment than after conventional estrogen treatment. This indicates that this substance might have an intracellular effect which is different and more pronounced that than of estrogen.
Differential uptake of 125i− and 99mtco4− in a histologically unusual metastatic thyroid carcinoma
Authors: Schall Gerald L. , Roth Joel A. , Temple Robert 
Published: February 2007

AbstractA case is presented of a histologically unique thyroid carcinoma metastatic to cervical lymph nodes which concentrated 99mTcO4− to a significantly greater degree than 125I−. This phenomenon may be related to 1. a decreased ability of the tumor to organify iodine, 2. an increased rate of turnover of the iodine‐labeled hormone by the tumor, or 3. the unusual “angiomatoid” pattern of the tumor and the difference in the blood levels of the two tracers at the time of the scans. Hot pertechnetate nodules must be rescanned with radioiodine.
Total laryngectomy and autogenous reconstruction observations in an experimental series in canines
Authors: Lapidot Abraham , Catalfumo Frank , Gelot Raghuvir , Liskow Arthur 
Published: February 2007

AbstractTwenty‐six dogs underwent total laryngectomy and autogenous reconstruction of the pharynx for the purpose of construction of a pseudolarynx. This simplified larynx demonstrated that it subserved the three major functions of the larynx; respiration, deglutition, and phonation in six of our 26 dogs which survived long enough for meaningful evaluation. Our surgical endeavors involve one of the most critical of areas in the body “the crossroads for air and food.” Despite some aspiration which we are still encountering with our present technique, the innervated tongue flap holds promise as a possible solution to this problem, and a detailed report will be submitted in due course.
Erythroplasia of queyrat (Bowen's disease of the glans penis)
Authors: Kaplan Carl , Katoh Arthur 
Published: February 2007

AbstractIt is suggested that the designation of erythroplasia of Queyrat should be restricted to cases of Bowen's disease or intraepithelial carcinoma of the glans penis in order to exclude more clearly the benign erythroplasias of the penis. Therapeutic measures should be directed at cure but also the maintenance of sexual and urethral function and sensation when possible. Traditionally, both invasive carcinoma and carcinoma‐in‐situ have been treated by amputation, electrosurgical dessication, or radiation therapy, and more recently topical chemotherapy for the superficial lesions. A mold technique with accurate dosimetry is described for use in an extensive case of erythroplasia of Queyrat involving the glans, prepuce and two‐thirds of the shaft with a successful early result and preservation of function and sensation to date.
The effect of a yeast extract (PCO) on the mitotic activity of neoplastic and normal cells in vitro
Authors: Fardon John C. , Poydock Sister M. Eymard , Tsuchiya Yoshiki 
Published: February 2007

AbstractAn aqueous‐alcoholic extract of yeast (PCO) was found to inhibit mitoses in Sarcoma 180, Krebs‐2 ascites carcinoma, and the L–1210 leukemia in vitro. Contrariwise, PCO did not inhibit, and in some experiments even stimulated, the mitoses in the following normal cells in vitro: L‐929 fibroblasts; two established lines of mouse corneal cells; and mouse bone marrow cells.
Pseudomonas meningitis complicating radical resection for radiorecurrent cancer of the paranasal sinuses: Report of two patients successfully treated with intrathecal polymyxin
Authors: Geelhoed Glenn W. , Ketcham Alfred S. 
Published: February 2007

AbstractPseudomonas meningitis is a grave complication of craniofacial surgery and radiotherapy. The management of this complication is reviewed and illustrated by the course of two patients who were successfully treated after radical resection for radiorecurrent cancer of the paranasal sinuses was complicated by pseudomonas meningitis.
Acute pulmonary oil embolism and lethal dose study of an oily contrast medium following portal vein administration into dogs
Authors: Lee Yeu‐Tsu N. , Donegan William L. 
Published: February 2007

AbstractIn the search for a simple, objective, reliable and sequential diagnostic hepatography, an oily contrast medium, Ethiodol {ethiodized oil), was purposely injected into the portal vein system of dogs. In the absence of a porto‐systemic shunt, the smallest amount of Ethiodol which produced faint roentgenographic visualization of pulmonary oil embolization was about 2.50 ml/kg. The average “trapping capacity” of the livers of six dogs was 2.89 ml/kg. The average acute lethal dose was 5.10 ml/kg. It was not possible to extrapolate the lethal dose of intraportal Ethiodol in humans. Also, the consideration of a threshold dose level (corresponding to the trapping capacity of the liver), near or above which the problem of pulmonary oil embolism will become significant, is only a rough concept. However, the results of this study serve to emphasize that the potential hazards of using intraportal oil contrast media for clinical purposes should be kept in mind.
Treatment of hodgkin's disease and other malignant lymphomas
Authors: Aungst C. W. 
Published: February 2007

AbstractConsiderable progress has been made in the treatment of Hodgkin's disease and the other lymphomas during the past 15 years. The present paper summarizes, in part, studies which our department has conducted or in which we have participated during this period. Studies of chlorambucil, prednisone, mitorgen mustard, vinblastine, cytoxan, and vincristine used as single agents have shown the efficacy of these drugs in the treatment of particular lymphomas. Our patients with late stage Hodgkin's disease have been treated in protocols of the Acute Leukemia Group B in which various types of combination chemotherapy, with or without maintenance therapy, have been and are being explored. In our studies, combination chemotherapy has shown no better results than single agent induction followed by oral maintenance therapy with chlorambucil or cytoxan in treating lymphosarcoma. Treatment of reticulum cell sarcoma remains discouraging.
Enhancement of the thymolytic effect of cortisone acetate by SCH 13521
Authors: Müuntzing J. , Stoliar J. B. 
Published: February 2007

AbstractSCH 13521 (4′‐nitro‐3′‐trifluoromethylisobutyranilide) given daily for 3 days to juvenile, adrenalectomized male rats did not affect the thymus weight even in toxic doses, nor did it enhance the thymolytic effect of simultaneously injected cortisone acetate (CA). However, the thymolytic effect of CA was doubled when injected simultaneously with SCH 13521 in adrenalectomized rats pretreated for 18 days with SCH 13521. In such rats also the CA‐induced liver weight increase was enhanced. The weights of the ventral prostate and the seminal vesicles were decreased by SCH 13521, which also decreased the testes weight, indicating an antigonadotropic effect of the drug.