bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental use of heterologous stroma‐free hemoglobin solution (SFHS) as a whole blood substitute
Authors: Holdefer Wilfred F. , Dowling Edmund A. 
Published: February 2007

AbstractNormothermic extracorporeal oxygenation and oxygen‐hemoglobin dissociation characteristics of stroma‐free hemoglobin solution (SFHS) were studied. One hour of normothermic cardiopulmonary bypass, using a total SFHS prime, resulted in arterial pH 7.31 – 7.38, PaO2 120 – 140 mm Hg, SaO2 99%, and mean arterial pressure of 85 mm Hg. One hour after perfusion, the animal died with acute pulmonary edema from severe hemodilution and hypoxemia. Hypothermic (25°C) myocardial metabolism was studied. Myocardial utilization (MU) values for oxygen, lactate, pyruvate, and glucose during SFHS perfusion were 1.46 and 1.71 m1/100 gm/min, +1.01 and +0.08 mg/100 gm/min, −0.32 and −0.04 mg/100 gm/min, and −34.4 and −9.50 mg/100 gm/min. MU values during whole blood perfusion were 2.21 and 2.13 m1/100 gm/min, −5.19 and −2.99 mg/100 gm/min, −0.65 and 0.22 mg/100 gm/min, and −13.7 and −5.32 mg/100 gm/min. These data suggest the necessity of further studies to identify any usefulness of SFHS as a whole blood substitute.
Cutaneous clues to malignant disease
Authors: Helm Frederick , Klein Edmund 
Published: February 2007

AbstractThe association of internal malignancies with cutaneous lesions has long been recognized. Since the skin can be examined easily, the entire integument should be carefully inspected whenever internal malignancy is suspected. Proper interpretation of cutaneous signs may be essential to a fast and accurate diagnosis of internal disease.A brief review of the cutaneous aspects of internal malignancy is presented, followed by a discussion of skin manifestations in which malignant cells are found in the skin. Also reviewed are nonspecific lesions (vascular reactions, pigmentary changes, hormonesecreting tumors, collagen diseases, etc.) in which no malignant cells are found in the skin but cutaneous changes are frequently enough related to neoplasm to make a complete work‐up mandatory. Genodermatoses, which are associated with an increased incidence of malignancy, are also discussed.
The effect of chronic thoracic duct drainage on cell antigenicity
Authors: Mandel Mark A. 
Published: February 2007

AbstractThe surface antigenic topography of thoracic duct cells is described. The cellular population is a heterogeneous one and accounts for the great variety of immunological functions in which these cells participate. Since the lymphatic system is an important route for tumor dissemination, the identification of circulating cells in the lymph by their antigenic confirmation may prove to be a vehicle for the early detection and treatment of cancer.
Evaluation of cardiac function during adriamycin therapy
Authors: Burg John R. , Moseley H. Stephens , Lindell Thomas D. , Kremkau E. Louise , Fletcher William S. 
Published: February 2007

AbstractLeft ventricular function was assessed in 21 patients treated with adriamycin, an antineoplastic antibiotic known to produce cardiac toxicity. The adriamycin dose utilized consisted of two loading courses (0.4 mg/kg for 3 days) separated by a 4‐day interval, followed by weekly doses of 0.4 mg/kg. The mean cumulative dose was 236 mg/m2 (range 74‐715 mg/m2). No patient developed frank cardiac decompensation during the period of observation. Significant changes in serum creatine phosphokinase levels or chest X‐rays were not seen. Electrocardiographic changes during therapy consisted of premature ventricular contractions and nonspecific ST‐T abnormalities in 4 and 5 patients, respectively. Subclinical alterations in cardiac performance definitely attributable to adriamycin, as evaluated by systolic time interval determinations, were not observed. Only one patient exceeded the critical level of 600 mg/m2 described by other investigators as the point where irreversible cardiac decompensation may occur. Further studies will be necessary to determine whether cardiac toxicity can be predicted by systolic time interval analysis and aborted by early termination of therapy.
Megestrol acetate for treatment of advanced carcinoma of the prostate
Authors: Johnson Douglas E. , Kaesler Kelly E. , Ayala Alberto G. 
Published: February 2007

AbstractThirteen men, ranging in age from 53 to 73 years and with previously untreated metastatic carcinoma of the prostate, received megestrol acetate (a synthetic progestin) in doses of 120 mg daily. A beneficial clinical response with a mean duration of 47 weeks was achieved in 12 patients (92%). When relapse developed in 8 patients, a secondary response was readily obtained by orchiectomy. The results suggest that a staged hormonal approach, using progestin therapy initially, may offer additional palliation in treating patients with metastatic prostatic carcinoma.
Evidence of oncogenic cofactors in radiation‐induced tumors in mice
Authors: Patricio M. B. , Clode W. H. , Ricardo J. A. 
Published: February 2007

AbstractFive groups of 587 inbred female mice (WHC) were studied to determine the incidence of tumors as affected by irradiation of different areas. A dose of 400 rad of 60Co was given to all the groups. One group of 166 mice was total body irradiated, another group of 90 mice was irradiated in the upper‐third portion of the body, another group of 93 mice was irradiated in the lower two‐thirds of the body, and another group of 90 mice was half body irradiated on the right side. As control, a group of 148 nonirradiated mice was followed. The results showed a different incidence of cancer in mice, depending not only on the irradiated areas but also on the shielded ones. This suggested that other factors besides irradiation affect carcinogenesis.
The role of the spleen and immunity in the metastatic pattern of a murine reticulum cell sarcoma
Authors: Faraci Robert P. , Schour Lionel 
Published: February 2007

AbstractA reticulum cell sarcoma (RCS) which initially metastasizes selectively to the spleen in C3H/HeN mice has been studied. Previous reports indicated that removal of the spleen results in widespread metastases of this tumor. The current experiments utilized a parabiotic system to determine the effect of additional splenic tissue on the gross and microscopic metastatic pattern of this RCS. The results were that the addition of a second spleen in the parabiotic group was followed by a significant decrease in visceral metastases compared with the splenectomized group. Parabiotic animals with splenectomized partners and sham‐operated animals did not significantly differ from control (single) animals, with all three of these poups showing visceral metastatic spread intermediate between the parabiotic and splenectomized groups. The protective effect of additional spleen against visceral metastases was found not to be immunologic, since immunosuppression of mice by irradiation produced a metastatic pattern similar to that of control animals.
Radiologic diagnosis of pancreatic cancer
Authors: Rösch J. 
Published: February 2007

AbstractModern radiology makes possible an accurate diagnosis of pancreatic cancer in about 95% of cases. Conventional upper gastrointestinal study, isotopic scanning, hypotonic duodenography, and ultrasonography are suitable as screening procedures. Special methods of high accuracy — pancreatic arteriography, endoscopic pancreatography, and transhepatic cholangiography are used as needed for definitive diagnosis.
Palatal reconstruction utilizing retrieved forehead flap
Authors: Chambers Robert G. , Cohn Edward S. 
Published: February 2007

AbstractAblation of tumors involving the tonsil and retromolar trigone complex often require partial resection of the soft palate. The pharyngeal wall defect is well reconstructed with the forehead flap. We have used the distal portion of the severed inserted forehead flap to reconstruct the soft palate defect successfully in 35 cases. The nasopharyngeal surface is lined with a book‐flap from the remaining palate. This provides full palatal reconstruction with nasopharyngeal mucosa lining; thus preventing flap contracture and the unwanted sequelae of nasopharyngeal air and fluid reflux.
Malignant melanoma and carcinoma of the breast
Authors: Lokich Jacob J. 
Published: February 2007

AbstractFive patients with breast cancer and malignant melanoma are reported. Two patients had a third primary malignancy. In 4 out of 5 patients the breast tumor was the initial tumor discovered, and in 4 out of 5 the second tumor evolved metachronously. No specific carcinogenic factor could be established. The low malignancy potential of the melanoma by pathologic criteria may explain the lack of previous reports of this association.
Cervical‐pectoral flaps in the treatment of advanced oral cancer
Authors: Shons Alan R. , McQuarrie Donald G. 
Published: February 2007

AbstractTwenty‐two of 90 patients with carcinoma of the anterior oral cavity treated at the Minneapolis Veterans Administration Hospital from 1965 through 1973 had advanced lesions—tumors attached to the mandible and/or more than 3 cm in size. These patients were treated by primary radical neck dissection, en bloc excision, and segmental mandibulectomy. A cervical‐pectoral flap combination was used for reconstruction. The functional and cosmetic results were excellent. Patient survival and cure rate compare favorably with other series. We emphasize the need for wide initial resection with immediate reconstruction.
Unusual lesions of the parotid gland
Authors: Katz Alfred D. 
Published: February 2007

AbstractTen unusual cases of parotid tumors are added to the literature from a series of 318 consecutive parotidectomies. These 10 cases are: 3 branchial cleft cysts; a lipoma; a lymphangioma; a hemangiopericytoma; a Boeck sarcoid; a metastasizing basal cell carcinoma; a lymphoma of the parotid; and a metastatic adenocarcinoma from the left breast to the right parotid. The lymphoma, Case 1, is also an example of some other cranial nerve taking over the function of the facial nerve when it is destroyed in early childhood. Though most tumors of the parotid gland are of the mixed type, many surprising findings are possible. The pathology report may be the first clue to a hidden systemic disease.
Appendectomy, tonsillectomy, and neoplasia
Authors: Lee Yeu‐Tsu N. 
Published: February 2007

AbstractReports in the literature that study the frequency of cancer in individuals who have had their tonsils or appendix or both removed are reviewed. Some investigators found a high incidence of solid cancers—in particular, breast and colon neoplasms—in female patients who have had appendectomy, but others disagreed. The association of tonsillectomy and/or appendectomy with the later development of malignant lymphomas is not proven.
Staging carcinoma of the penis
Authors: Baker Burton H. , Watson Frank R. 
Published: February 2007

AbstractPresently there are six clinical staging systems in use for carcinoma of the penis. We propose a method which compares these systems by means of a check list type of format. With the aid of this device, any penile carcinoma can readily be staged in terms of all six systems. Advantages of multiple system staging include comparing series of patients which have been discussed only in terms of a single staging system and selecting the appropriate therapeutic modality in terms of the stage of disease.
Rectocolic reconstruction via a modified kraske approach
Authors: Douglass H. O. , Karakousis C. , Holyoke E. D. 
Published: February 2007

AbstractIn carefully selected patients, the sacrococcygeal approach (Kraske's operation) with rectal colostomy can save a patient from abdominoperineal resection without loss of continence. This procedure is also useful in the management of rectal strictures that occasionally occur after leaks from the anastomosis of a low anterior resection of the rectosigmoid colon. Three illustrative cases are presented and discussed.
Cancer of the gastric stump following operations for benign gastric or duodenal ulcers
Authors: Gazzola L. M. , Saegesser F. 
Published: February 2007

AbstractTwenty‐seven patients who developed cancer of the stomach after undergoing gastric resection (GR), gastroenterostomy (GE), and vagotomy and pyloroplasty (VP) for benign gastric or duodenal ulcer are reported. The etiology and the pathogenesis of this type of cancer are discussed. Long‐term exposure of the gastric mucosa to bile and duodenal and pancreatic secretion reflux seems to create a premalignant potential state. Symptoms and the diagnostic methods of radiologic series, cytology, and endoscopy are discussed. We suggest a curative operative approach and discuss the poor value of palliative procedures. We emphasize the necessity of determining the prognosis with exploratory laparotomy which establishes at the same time the certitude of the diagnosis.
Skin test with tumor extract in bronchogenic carcinoma: A preliminary study
Authors: Marabella Patrick C. , Takita Hiroshi 
Published: February 2007

AbstractTumor‐specific immunity using delayed hypersensitivity skin testing with extract of undifferentiated carcinoma of the lung was evaluated in 25 consecutive patients with carcinoma of the lung. Eight out of 25 patients reacted well to intradermal injection of the tumor extract. All of the 8 patients were found to have limited disease, and their survival times were longer than those with poor reaction.
A human/mouse hybrid model for the study of human genetic factors influencing tumor cell growth
Authors: Koshman Robert W. , Koo Jarley , Thurston Olin G. 
Published: February 2007

AbstractSomatic cell hybridization (fusion) was carried out between cells of the murine lymphoma L‐5178Y(r) and peripheral human lymphocytes. The L‐5178Y(r) line is deficient in hypoxanthine‐guanine phosphorybosyl transferase (HGPRT). Using a selective medium system, it was possible to isolate hybrid cell clones having the complete complement of murine chromosomes as well as the human X chromosome on which the gene for HGPRT is located. This model system may be used to study the effect of the human X chromosome on the phenotype of the murine lymphoma.
Treatment of disseminated cancer by intravenous hydroxyurea and autogenous bone‐marrow transplants: Experience with 35 patients
Authors: Ariel Irving M. 
Published: February 2007

AbstractMassive doses of hydroxyurea (Hydrea) were given to 35 patients suffering from different cancers. Protection to the hematopoietic system was obtained by autogenous marrow transfusions.The clinical response obtained was not considered superior to the results obtained by administering the drug orally over a prolonged period.The described technique is safe and relatively atraumatic, and it may be advisable to administer a large priming dose by this technique to be followed by smaller maintenance doses of a given anticancer chemotherapeutic agent.
Offsetting toxicity of antineoplastic agents
Authors: Cook Elton S. , Nutini Leo G. , Fardon John C. , Bernadette Proudfoot M. Agnes , Poydock M. Eymard 
Published: February 2007

AbstractPCO, a yeast extract, offsets at least in part the mitotic inhibitory effect of methotrexate and fluorouracil on bone marrow cells in vitro but increases the antimitotic activity of the drugs on ascites Krebs‐2 carcinoma under similar conditions. In vivo, PCO enhances the action of methotrexate against the L‐1210 lymphoid leukemia and does not interfere with the effectiveness of fluorouracil against the ascites Krebs‐2 tumor.
A computerized tumor‐registry system for persons who do not love computers
Authors: Johnson Ileana C. , Blumenson Leslie E. , Bross Irwin D. J. 
Published: February 2007

AbstractA new simplified system for updating a cancer registry has been developed in the Biostatistics Department of Roswell Park Memorial Institute. It was designed to serve the needs of maintaining a registry for a cooperative cancer research group. The Data‐Update Procedure at a Remote Terminal (DUPART) system has general value for registry applications.
Colorectal cancer—prognostic signs in “local disease”
Authors: Lerner Harvey J. 
Published: February 2007

AbstractThis detailed review of the clinical and pathologic signs which effect the prognosis of patients with colorectal cancer. The following are reviewed: (1) the degree of cellular anaplasia, (2) local penetration of the bowel wall, (3) lymph‐node spread, (4) venous invasion, (5) perineural invasion, (6) obstruction and perforation, and (7) the number of cm the lesion is located from the anal verge.
Inhibition of melanoma growth in hamsters by type‐2 adenovirus
Authors: Khoobyarian Newton , Barone Frank , Sabet Tawfik , El‐Domeiri Ali A. , Gupta Tapas K. Das 
Published: February 2007

AbstractType‐2 adenovirus was shown to inhibit the growth of transplantable hamster melanoma in 70% of Syrian hamsters without any injurious effect to the host. Greatest inhibition of tumor formation was seen when animals were injected with 106 TCD50 of adenovirus and 2.5 × 105 tumor cells, or 106 TCD50 of virus and 5.0 × 105 tumor cells followed either 1 or 7 days later by a second injection of a similar dose of virus. Significant inhibition in tumor growth was also noted when 2 injections of virus (106.2 TCD50/injection) were given on 2 separate occasions as late as 7 and 10 days after the inoculation of tumor cells. The mechanism of tumor inhibition is not known but it could be due to a combination of factors such as viral toxicity, viral oncolysis, and antitumor immunity.
A single moment roentgen contrast study of superior cava and its tributaries
Authors: Shumakov A. G. , Pozmogov A. I. 
Published: February 2007

AbstractThe method of single moment roentgen study of the superior vena cava and its tributaries is presented. The roentgen anatomic data concerning occurring variants of normal mediastinal venous vessel branches and their layout are given. Some examples show the diagnostic value of the mediastinal phlebography using the method described above.
Fibrous dysplasia of the sphenoid sinus in an adolescent male
Authors: Faraci Robert P. , Ketcham Alfred S. 
Published: February 2007

AbstractFibrous dysplasia involving the sphenoid sinus and the entire left sphenoid bone, manifested clinically by left proptosis and frontal headaches, was disagnosed in a 13‐year‐old black male. The case is unusual since it is only the third reported instance of fibrous dysplasia of the sphenoid sinus, and because the disease became clinically apparent at the onset of puberty in the patient. Since previous reporters have suggested that fibrous dysplasia remains stable or progresses slightly after the onset of puberty, the patient was not treated with radical surgery, but instead was observed closely. At this point, one year following admission, the patient's proptosis has disappeared and his symptoms are markedly improved.
Estrogen and estrogen receptors of breast cancer
Authors: Sahadevan Velayudan , Perlia Charles P. , Economou Steven G. , Sky‐Peck Howard 
Published: February 2007

AbstractHuman breast cancer can be divided into a group that contains specific receptor sites for estrogen and a group without such specific estrogen‐binding sites. The presence of specific estrogen receptors in some tumors indicating hormonal dependency has been shown to be of predictive value for endocrine treatment. This would greatly improve therapeutic planning for patients with breast cancer.Tumor tissue from 52 patients was investigated for content of both cytosol estrogen and estrogen receptor. In addition, the total tumor estrogen was also determined in 14 of these tumors. The results of this investigation show two distinct groups: one group containing both estrogen receptor and estrogen and a second group with no receptor but with measurable amount of estrogen. Tumors with estrogen receptors have higher tissue levels of estrogen than tumors without specific estrogen receptor. Even in the absence of estrogen receptor, however, most tumor tissue examined contained a measurable amount of estrogen.
Cytotoxicity reactions during immunotherapy of melanoma with neuraminidase altered autologous tumor cells
Authors: Miller Elizabeth E. , Rosato Francis E. , Brown Arthur S. , Moskovitz Anne , Johnson Joan 
Published: February 2007

AbstractLymphocyte cytotoxicity, serum cytotoxicity, and the ability of the serum to inhibit lymphocyte cytotoxicity (blocking effect) were studied in a melanoma patient treated with six monthly injections of her own (autologous) tumor cells incubated with neuraminidase to increase their antigenicity. The same tumor cells grown in tissue culture were used as target cells for the cytotoxicity test. Large fluctuations of blocking effect in the serum were found, which correlated with the clinical course of tumor removal, recurrence, and regression. After the fifth injection of autologous tumor cells, the blocking effect disappeared from the serum (unblocking). In general, changes in serum cytotoxicity corresponded with changes in the amount of blocking effect produced by the serum. The results suggest that active immunotherapy may play a role in the prevention of metastases and, that when used within the autologous system, the cytotoxicity test is valuable in studying response to this type of therapy.
A randomized pilot study comparing two regimens in the treatment of squamous cell carcinoma
Authors: Moseley H. Stephens , Sasaki Truman , McConnell Donald B. , Merhoff G. Craig , Wilson William L. , Grage Theodor B. , Wiess Arthur J. , Fletcher William S. 
Published: February 2007

AbstractThirty‐five patients with epithelial carcinomas not considered to be surgically resectable were randomized to receive two different chemotherapy regimens. Regimen 1 was CCNU followed by bleomycin, and Regimen 2 was a combination of CCNU, bleomycin, methotrexate, and vinblastine. Five of 14 patients treated with CCNU‐bleomycin had partial responses. Three of 15 patients treated with the four‐drug combination had a partial response.The toxicity of the four‐drug regimen was significantly greater than that of the two‐drug regimen, while the response rate was greater among those patients treated with two drugs. No significant clinical infections occurred despite the fact that leukopenia and thrombocytopenia were more severe and frequent with the four‐drug regimen.Most importantly, the two‐drug regimen is well tolerated as an outpatient procedure. Two of the two‐drug and one of the four‐drug recipients were converted from an inoperable to an operable state. In view of the fact that there has not heretofore been an effective chemotherapeutic regimen for Stage III and IV squamous carcinoma, this is a significant observation. It is of note that patients with squamous cell carcinoma of the head and neck were those who responded best to this treatment, although the treatment is worthy of consideration for advanced squamous carcinoma in other areas.
A survey of epithelial inclusions in the ovarian cortex of 470 patients
Authors: Mulligan R. M. 
Published: February 2007

AbstractThe ovaries of 470 patients obtained for various indications at operation revealed 178 with 193 ovarian cysts and tumors ‐ including 63 serous, 23 endometrial, and 27 mucinous ‐ as well as 103 with tubal (serous), 35 with endometrial, and 2 with cervical (mucinous) epithelial inclusions. A very high frequency of transformation of mucinous epithelial inclusions into cysts and tumors contrasted with about 40% similar transformation of serous and endometrial inclusions into cysts and tumors.