bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor-naïve pre-surgical ctDNA detection is prognostic in clinical stage I lung adenocarcinoma
Authors: Hong Tae Hee , Hwang Soohyun , Dasgupta Abhijit , Abbosh Christopher , Hung Tiffany , Bredno Jörg , Walker Jill , Shi Xiaojin , Milenkova Tsveta , Horn Leora , Choi Joon Young , Lee Ho Yun , Cho Jong Ho , Choi Yong Soo , Shim Young Mog , Chai Shoujie , Rhodes Kate , Roychowdhury-Saha Manami , Hodgson Darren , Kim Hong Kwan , Ahn Myung 
Published: April 2024

Abstract
We assessed pre-surgical diagnostic circulating tumor DNA (ctDNA) status in 895 patients with EGFR/ALK-wild-type, clinical stage I–II non-small-cell lung cancer using a tumor-naïve methylation-based cell-free DNA assay. Pre-surgical ctDNA detection was observed in 55/414 (13%) patients with clinical stage I lung adenocarcinoma (LUAD) and was associated with poor recurrence-free survival (RFS) (2-year RFS 69% versus 91%; log-rank P < 0.001), approaching that of clinical stage II LUAD. Pre-surgical ctDNA detection was not prognostic in patients with clinical stage II LUAD or non-LUAD. Within LUAD, tumor volume interacted with positron emission tomography avidity to predict pre-surgical ctDNA detection, and pre-surgical ctDNA detection correlated with high-grade pathological features, programmed death ligand-1 (PD-L1) positivity, and pathological upstaging. Our findings support pre-surgical ctDNA positivity as an adverse prognostic feature specifically in clinical stage I LUAD. This validated observation using a tumor-naïve assay will enable perioperative trial advances targeted toward patients with high-risk disease.
Computational Modeling of Regional Dynamics of Pandemic Behavior using Psychologically Valid Agents
Authors: Pirolli Peter , Teng Choh Man , Lebiere Christian , Mitsopoulos Konstantinos , Morrison Don , Orr Mark 
Published: April 2024

Abstract

Regional Psychologically Valid Agents (R-PVAs) are computational models representing cognition and behavior of regional populations. R-PVAs are developed using ACT-R—a computational implementation of the Common Model of Cognition. We developed R-PVAs to model mask-wearing behavior in the U.S. over the pre-vaccination phase of COVID-19 using regionally organized demographic, psychographic, epidemiological, information diet, and behavioral data. An R-PVA using a set of five regional predictors selected by stepwise regression, a psychological self-efficacy process, and context-awareness of the effective transmission number, Rt, yields good fits to the observed proportion of the population wearing masks in 50 U.S. states [R2 = 0.92]. An R-PVA based on regional Big 5 personality traits yields strong fits [R2 = 0.83]. R-PVAs can be probed with combinations of population traits and time-varying context to predict behavior. R-PVAs are a novel technique to understand dynamical, nonlinear relations amongst context, traits, states, and behavior based on cognitive modeling.
The Flooding of Lagash: Evidence for Urban Destruction under Lugalzagesi, the King of Uruk
Authors: Goodman Reed , Giosan Liviu , Shen Zhixiong , Lang Andreas , Zimmerman Paul , Constantinescu Stefan , Pizzimenti Sara , Alrawi Zaid , Pittman Holly 
Published: April 2024

Abstract

New research at Tell al-Hiba, ancient Lagash, has uncovered evidence of extensive flooding and sitewide destruction in the latter half of the third millennium BC. Specifically, we characterize and date a prominent water-formed feature that crosses the heart of Lagash’s former temple district. Geoarchaeological trenching and geophysical prospection indicate that the feature, consisting of a series of meander point and counterpoint bars, intercepted and overlies late Early Dynastic cultural materials, suggesting that upstream river avulsion resulted in the rapid and energetic fluvial sedimentation. Based on the site’s broader geomorphological context, this process would have played out widely across the city’s hinterland, leaving lasting consequences, including spatially extensive soil salinization and waterlogging. Additional archaeological, radiometric, and historical data allow us further to propose that this flooding likely developed during or shortly after Lagash was attacked by Lugalzagesi, a king of Uruk. In combination with the site’s surface ceramic record, our evidence indicates that much of the city’s population left in direct response. Ultimately, this work provides evidence of urban environmental devastation through warfare at an early period in time, and it also contributes to the chronometry of 3rdmillennium dynastic history in Mesopotamia.
Insilco analysis of an interaction between an endogenous peptide fragment of NUR77 receptor from human cells and USAG1 protein - may induce teeth regeneration
Authors: VAITHYANATHAN PRAKASH 
Published: April 2024

Abstract
BMP-7 and WNT signaling are responsible for the development of teeth. USAG-1 (uterine sensitization associated gene-1) inhibits bone morphogenetic protein-7 protein (BMP-7) as well as WNT receptors leading to suppression of tooth development and growth. The inhibition of USAG-1 using an antibody has been shown to induce tooth regeneration in mice. Hence, USAG-1 is a drug target that is promising enough for teeth generation. In this paper, for the first time, it has been proposed that an endogenous peptide that is part of the NUR-77 receptor in human cells may inhibit USAG-1 protein to induce tooth regeneration when injected locally. The peptide FSRSLHSL of the NUR-77 receptor interacts with the usag-1 protein through enough hydrogen bonds as shown by the docking studies. BCL-2 expression determines the mineralogical composition of enamel crystals of tooth structure. The peptide FSRSLHSL doesn’t convert the character of BCL-2 to proapoptotic although the addition of an extra amino acid “L” to derive FSRSLHSLL leads to an orthogonal behavior.
Centrality-based nearest-neighbor projected-distance regression (C-NPDR) feature selection for correlation predictors with application to resting-state fMRI of major depressive disorder
Authors: Kresock Elizabeth , Luttbeg Henry , Li Jamie , Kuplicki Rayus , McKinney B. A. , McKinney Brett , Dawkins Bryan 
Published: April 2024

Abstract
Background.
Nearest-neighbor projected-distance regression (NPDR) is a metric-based machine learning feature selection algorithm that uses distances between samples and projected differences between variables to identify variables or features that may interact to affect the prediction of complex outcomes. Typical bioinformatics data consist of separate variables of interest like genes or proteins. In contrast, resting-state functional MRI (rs-fMRI) data is composed of time-series for brain Regions of Interest (ROIs) for each subject, and these within-brain time-series are typically transformed into correlations between pairs of ROIs. These pairs of variables of interest can then be used as input for feature selection or other machine learning. Straightforward feature selection would return the most significant pairs of ROIs; however, it would also be beneficial to know the importance of individual ROIs.
Results.
We extend NPDR to compute the importance of individual ROIs from correlation-based features. We present correlation-difference and centrality-based versions of NPDR. The centrality-based NPDR can be coupled with any centrality method and can be coupled with importance scores other than NPDR, such as random forest importance. We develop a new simulation method using random network theory to generate artificial correlation data predictors with variation in correlation that affects class prediction.
Conclusions.
We compare feature selection methods based on detecting functional simulated ROIs, and we apply the new centrality NPDR approach to a resting-state fMRI study of major depressive disorder (MDD) and healthy controls. We determine that the areas of the brain that are the most interactive in MDD patients include the middle temporal gyrus, the inferior temporal gyrus, and the dorsal entorhinal cortex. The resulting feature selection and simulation approaches can be applied to other domains that use correlation-based features.
Adrenomedullin level in children with congenital adrenal hyperplasia: Relationship to vascular and left ventricular functions
Authors: Farghaly Hekma , Eltayeb Azza , Metwallley Kotb Abbas , Mohammad Shimaa kamal , Kandiel Randa A. , Saied GhadaMohamed ,   Azhar arabi Mohammed1
Published: April 2024

Abstract

Purpose: To evaluate left venticular, vascular endothelial function and its association with adrenomedullin (AM) levels in children with classic CAH.
Methods: 42 children with classic CAH (mean age of 13.5±2.4 years) were compared to 42 healthy controls. Measurement of 17-hydroxy-progesterone, total testosterone, and AM levels were carried out. LV functions and cardiac dimensions were measured with traditional echocardiography. Brachial artery flow-mediated dilation (FMD%) and carotid intima-media thickness (CA-IMT) were measured via vascular ultrasonography. According to the control on medical treatment, patients were classified into poor (n = 12) and good (n = 30) controlled groups.
Results: Patients had significant higher AM levels and LVM index (LVMI), while lower brachial FMD%, a thicker CA-IMT, and a prolonged mitral deceleration time (DcT) in relation to controls. These changes were marked in children with poorly controlled on medical treatment. In multivariate analysis, AM levels were significantly correlated with systolic (OR =; 95% ) and diastolic blood pressures (OR = 2.9; 95% ), Testosterone ( OR =3.46; 95% CI = 1.55-2.13, ), LVMI (OR = 2.6; 95% CI: 1.1– 1.13), mitral DcT (OR = 2.4; 95% CI: 1.15–2.05; ), CA-IMT (OR = 1.6; 95% CI: 1.16–1.57) ,and FMD% (OR =2.6; 95%CI = 1.33-2.89) .
Conclusions: AM level was elevated in children with classic CAH, especially in those not well controlled on medical treatment, and it was correlated with LVMI, mitral DcT, CA-IMT, and FMD%. Children with CAH who are at increased risk of developing subclinical CV problems may benefit from measuring AM level.
Climate Change-Related Drivers of Migration in East Africa: An Integrative Review of the Literature
Authors: Chetto Reginald , Mdemu Makarius , Kihila Jacob 
Published: April 2024

Despite the growing academic concern and policy interest in climate change drivers of migration, scientific evidence on the topic remains contested, with divergent claims of positive and negative contributions of climate change on human migration and displacement. This review seeks to assess the climate change-related drivers of migration with a focus on three East African countries: Tanzania, Kenya, and Uganda. They are among the most vulnerable countries in Africa, with one of the most mobile populations. The study used the available literature on climate change and migration as the data source. About 22 research articles on climate change and migration were sourced from the Web of Science and Scopus databases and critically reviewed. The review generally indicates that climate change effects such as frequent drought and flood disasters, livestock pests, and crop diseases influence migration and displacement in the region. On the other hand, rising sea levels pose imminent risks that can cause migration if adaptation measures are not taken. The review has also revealed that responses to drought or livestock and crop diseases, be it localized adjustment or out-migration, are determined by households' adaptive capacity. For rapid onset climate events such as floods, the most vulnerable are the less fortunate living in poorly constructed structures in flood-prone zones. This review proposes strengthening the climate policy framework by mainstreaming climate change migration in East African nations’ adaptation plans. It also calls for promoting alternative livelihood activities as an adaptation strategy in areas prone to climate change to lessen human-forced migration and displacement.
Assessing the Level of Employees' Sustainability Awareness and its Effect on Sustainable Development Progression - A Case Study of Greater Karak Municipality/ Jordan
Authors: El-Shqeirat Sara 
Published: April 2024

The current discourse on Sustainability Awareness (SA) is mainly focused on offering employees environmental training and education that aims to increase their participation in the organization's sustainable progress. Hence, overlooking the importance of the SA policy-making phase as well as the critical role designing SA programs plays in activating employees' efficient contribution to sustainability initiatives. Therefore, the significance of this research lies in offering an alternative model that integrates both processes of measuring and raising SA with the prospect of altering the organization's culture where sustainability value is created to motivate employees' engagement. In addition, this research will justify the failure of cases where environmental education, training, and SA programs did not positively affect employees' engagement nor did they benefit the organization's sustainable progress. This research presents organizations and decision-makers with a new approach to raising SA levels aiming to increase the potential for effective employment of the newly acquired knowledge. Hence, makes sustainable achievements more tangible. This model suggests the use of a qualitative approach to measuring employees' SA levels; a model that includes collecting data on employees' insights, conceptions, sources of knowledge, and personal experiences of sustainability. This model would replace the commonly used quantitative approach to measure SA which is limited to analyzing data numerically to draw a statistical picture aiming to determine whether a pre-designed SA program should be implemented. Instead, managers could benefit from the data collected in the SA measuring process to identify the focus areas of the SA-raising program. Furthermore, such data would help organizations design SA programs that are specifically tailored to target a change in their employees' mindset and beliefs.
The 2021 extreme rainfall in Gävle, Sweden: impacts on municipal welfare services and actions towards more resilient premises and operations
Authors: Glaas Erik , Hjerpe Mattias , Storbjörk Sofie 
Published: April 2024

Abstract
Climate-related risks, vulnerabilities, and impacts are increasing in cities, illustrated by precipitation-driven pluvial floods. Post-event analyses can aid in reducing urban flood risks, but knowledge gaps exist regarding how welfare services and premises are impacted and can be adapted. This study analyses an extreme precipitation-driven event generating extensive flooding in Gävle, Sweden, in 2021. The objective is to increase knowledge about how municipal welfare services are vulnerable to pluvial floods, and of appropriate actions towards improving the response capacity and building more resilient welfare premises and operations. The study shows that the Swedish weather warning system generally worked well, but the analysed property companies lacked strategies and equipment to evade flooding in their properties. Flood damages in 60 analysed buildings were generated by different causes, demonstrating the importance of contemplating the vulnerability of welfare buildings when conducting flood risk assessments. Although the flood event did not cause deaths or serious personal injuries, the study identified impacts on welfare service operations in both the short and long terms. The event increased learning on climate adaptation but did not trigger adaptive action. Identified keys for adaptation include prioritizing premises to protect, knowledge of flood protection equipment, insurance company requirements, and updated emergency plans.
STRATEGI KOMUNIKASI TEPAS TANDHA YEKTI DALAM MENGELOLA CITRA POSITIF KRATON YOGYAKARTA MELALUI MEDIA SOSIAL INSTAGRAM
Authors: Putri Alvita Dewi , Hastasari Chatia 
Published: April 2024

Penelitian ini bertujuan untuk mendeskripsikan; 1) strategi komunikasi Tepas Tandha Yekti dalam mengelola citra positif Kraton Yogyakarta melalui media sosial Instagram dengan model komunikasi Lasswell; 2) Hambatan dan tantangan strategi komunikasi yang dilakukan Tepas Tandha Yekti dalam mengelola citra positif Kraton Yogyakarta melalui media sosial Instagram. Penelitian yang dilaksanakan di Kraton Yogyakarta ini menggunakan pendekatan kualitatif. Pengumpulan data dilakukan dengan wawancara, informan ditentukan menggunakan teknik purposive sampling. Pemeriksaan keabsahan data dengan triangulasi sumber. Analisis data melalui tahap pengumpulan data, reduksi data, sajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan; 1) Strategi komunikasi Tepas Tandha Yekti mengelola citra positif kraton Yogyakarta melalui media sosial Instagram meliputi seluruh elemen yang ada dalam komunikasi, a) Komunikator yaitu Penghageng/ pemimpin Tepas Tandha Yekti Project Manager; b) Pesan yang disampaikan informatif, edukatif persuasif melalui pengelolaan konten digital; c) Media sosial yang digunakan adalah Instagram; d) Komunikan yaitu masyarakat diaspora; masyarakat menganggap negatif dan generasi muda yang mulai acuh terhadap kebudayaan Jawa dan adat istiadat kraton Yogyakarta; e) Umpan balik atau feedback yang diterima adalah feedback positif dan negatif; dan 2) Dua hambatan implementasi strategi komunikasi yaitu hambatan proses produksi konten dan hambatan semantik; Tantangan yang dihadapi adalah permintaan topik bahasan di Instagram dari followers yang memerlukan pengkajian ulang serta riset yang lebih mendalam.Kata kunci: Strategi Komunikasi, Tepas Tandha Yekti, Citra Positif Kraton, Media Sosial Instagram
PENGARUH TERPAAN TAYANGAN DRAMA KOREA TERHADAP KEPUTUSAN PEMBELIAN PRODUK KULINER KOREA
Authors: HAQ Shafir WALIDA , Suranto Suranto 
Published: April 2024

Penelitian ini bertujuan untuk untuk mengetahui pengaruh terpaan tayangan drama Korea terhadap keputusan pembelian produk kuliner Korea. Penelitian ini menggunakan pendekatan kuantitatif, dengan jenis penelitiannya adalah penelitian survei. Data yang digunakan merupakan data hasil pengisian kuesioner oleh para responden yang termasuk dalam kategori mahasiswi K-popers dalam rentang umur 21 sampai 24 tahun. Pengolahan data hasil kuesioner menggunakan perangkat lunak SPSS versi 25. Populasi dalam penelitian ini adalah perempuan berusia 20-24 tahun di Sleman, Yogyakarta dengan jumlah 18.082 orang. Pengambilan sampling dalam penelitian ini menggunakan teknik Multistage Random Sampling, dan ditentukan sebanyak 100 sampel. Hasil penelitian ini adalah terdapat pengaruh positif dan signifikan antara terpaan tayangan drama Korea terhadap keputusan pembelian produk kuliner Korea dimana 𝑟ℎ𝑖𝑡𝑢𝑛𝑔 lebih besar dari 𝑟𝑡𝑎𝑏𝑒𝑙 (0,588 0,163). Hasil dari uji signifikansi menggunakan korelasi Product Moment menunjukkan jika hipotesis diterima sehingga terdapat pengaruh positif dan signifikan antara terpaan tayangan drama Korea terhadap keputusan pembelian produk kuliner Korea. Kata kunci: terpaan media, keputusan pembelian, K-Pop, kuliner Korea, drama Korea
STRATEGI KOMUNIKASI PEMASARAN OBJEK WISATA GEREJA AYAM BUKIT RHEMA (WISATA ALAM, RELIGI, KULINER DAN EDUKASI)
Authors: Rizaldi Naufal Rezky , Machmiyah Siti 
Published: April 2024

Penelitian ini bertujuan untuk mendeskripsikan; 1) strategi komunikasi pemasaran objek wisata Gereja Ayam Bukit Rhema 2) usaha pengelola objek wisata Gereja Ayam Bukit Rhema dalam menyebarkan edukasi dan toleransi umat beragama. Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif. Hasil penelitian ini sesuai dengan langkah-langkah strategi komunikasi pemasaran dalam kajian Agus Hermawan yaitu a) khalayak sasaran objek wisata Gereja Ayam Bukit Rhema yaitu wisatawan domestik; b) tujuannya meningkatkan jumlah kunjungan wisatawan dan mengenalkan konsep empat wisata (alam, religi, kuliner dan edukasi); c) pesan dilakukan secara intensif dengan mengunggah post dan story di media sosial; d) saluran personal yang digunakan adalah melalui pameran dan tim yang disediakan di pintu masuk sedangakan saluran non personal adalah melalui media online seperti website dan sosial media dan juga melalui media siaran e) anggaran promosi ditetapkan dengan metode tujuan dan tugas; f) bauran promosi yang digunakan yaitu periklanan, promosi penjualan, acara, humas publisitas, pemasaran langsung, pemasaran dari mulut ke mulut dan penjualan personal; g) mengukur hasil promosi dilakukan dengan melihat data penjualan; h) mengoordinasi proses komunikasi yang terintegrasi, dilakukan oleh bagian pemasaran. Kata kunci: komunikasi pemasaran, strategi komunikasi pemasaran, toleransi, pariwisata, gereja ayam bukit rhema
AKTIVITAS MEDIA RELATIONS BIDANG HUMAS POLDA D.I. YOGYAKARTA DALAM MEMBANGUN CITRA POSITIF
Authors: Astuti Alfi Yuni , Suranto Suranto 
Published: April 2024

Penelitian ini bertujuan untuk mendeskripsikan 1)aktivitas media relations Bidhumas Polda D.I. Yogyakarta dalam membangun citra positif 2) faktor pendukung dan penghambat aktivitas media relations yang dilaksanakan Bidhumas Polda D.I. Yogyakarta. Penelitian ini menggunakan pendekatan kualitatif dengan metode deskriptif. Hasil penelitian menunjukkan; 1) arti penting media relations bagi Bidhumas Polda D.I. Yogyakarta adalah a)sebagai sarana untuk pubikasi informasi ke khalayak luas; b) sebagai transparasi kegiatan kepada masyarakat; c) sebagai sarana penghubung antara kepolisian, media dan masyarakat; d) sebagai sarana pembelajaran dalam pengelolaan informasi; 2) Bidhumas Polda D.I. Yogyakarta melaksanakan aktivitas media relations antara lain konferensi pers, press briefing, press release, press luncheon, press tour, wawancara pers dan media visit; 3) Bidhumas Polda D.I. Yogyakarta meningkatkan citra positif melalui media relations dengan langkah memproduksi konten positif.Konten positif tersebut berupa prestasi yang diraih anggota Polda D.I. Yogyakarta dan berbagai kegiatan yang diadakan Polda D.I. Yogyakarta untuk masyarakat. 4) Faktor pendukung aktivitas media relations yang diadakan meliputi a) perencanaan yang baik b) komunikasi yang baik c) materi. Sedangkan faktor penghambat aktivitas media relations mencakup a) miss komunikasi b) anggaran dana c) terbatasnya slot pemberitaan pada media cetak dan elektronik d) tuntutan berita online yang cepat terkadang menghasilkan berita yang kurang akurat. Kata kunci: media relations, Bidhumas Polda D.I. Yogyakarta, citra positif