bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of information satisfaction, psychological distress and monitoring coping style with post‐decision regret following breast reconstruction
Authors: Sheehan Joanne , Sherman Kerry A. , Lam Thomas , Boyages John 
Published: July 2006

AbstractLittle is known of the psychosocial factors associated with decision regret in the context of breast reconstruction following mastectomy for breast cancer treatment. Moreover, there is a paucity of theoretically‐based research in the area of post‐decision regret. Adopting the theoretical framework of the Monitoring Process Model (Cancer 1995;76(1):167–177), the current study assessed the role of information satisfaction, current psychological distress and the moderating effect of monitoring coping style to the experience of regret over the decision to undergo reconstructive surgery. Women (N=123) diagnosed with breast cancer who had undergone immediate or delayed breast reconstruction following mastectomy participated in the study. The majority of participants (52.8%, n=65) experienced no decision regret, 27.6% experienced mild regret and 19.5% moderate to strong regret. Bivariate analyses indicated that decision regret was associated with low satisfaction with preparatory information, depression, anxiety and stress. Multinominal logistic regression analysis showed, controlling for mood state and time since last reconstructive procedure, that lower satisfaction with information and increased depression were associated with increased likelihood of experiencing regret. Monitoring coping style moderated the association between anxiety and regret (β=−0.10, OR=0.91, p=0.01), whereby low monitors who were highly anxious had a greater likelihood of experiencing regret than highly anxious high monitors. Copyright © 2006 John Wiley & Sons, Ltd.
System development and demonstration of a UAV control architecture for information gathering missions
Authors: Cole David T. , Sukkarieh Salah , Göktoğan Ali Haydar 
Published: July 2006

AbstractThis paper presents a system architecture for unmanned aerial vehicles (UAVs) performing information gathering missions. Particular focus in this paper is on the development of the architecture from algorithms to simulation, hardware‐in‐the‐loop testing and flight demonstrations. The architecture has been developed for a team of Brumby Mk 3 fixed wing UAVs. Results from recent flight demonstrations are presented in which a single UAV validated a path‐following guidance algorithm for feature orbiting, and a utility‐based dynamic path planning algorithm applied to a feature tracking problem. The architecture has also been designed to accommodate the use of multiple UAVs, and future work on a team approach to the problem is presented. © 2006 Wiley Periodicals, Inc.
On the performance of proactive mobile IPv6 for context‐aware all‐IP wireless access networks
Authors: Pagtzis Theo , Crowcroft Jon , Clark Keith 
Published: July 2006

AbstractA major challenge in building ‘all‐IP’ wireless access networks, besides the use of IP as the unifying layer, relates to the transparency of the IP handoff process as the mobile node (MN) transits across heterogeneous wireless network domains in IPv6 mobility management. Transparency in IP handoffs, however, must be effected in two separate contexts: IP‐addressing and (re‐)connection latency. Excessive delays during an IP handoff degrades the seamlessness of IP transmission between the MN and its peers.Motivated by experimental results over heterogeneous wireless networks, we discuss why dynamic establishment of IP context‐state can help address these limitations that seem inherent in heterogeneous environments. To this end, we provide an in‐depth evaluation of Proactive Mobile IPv6 by means of simulations.Our study contrasts the efficiency of proactive context‐state establishment, between candidate points of attachment (PoAs), against reactive MIPv6 standard practices over handoff delay, jitter and associated packet loss. Departing from reactive MIPv6 standards, this study brings new insights towards seamless handoffs by investigating the influential aspects of non‐determinism in the mobility pattern of the MN. In addition, it demonstrates quantitatively the performance benefit attained by maximising MN's service utility through PoA selectivity embedded in MN IPv6 handoff decision. Copyright © 2006 John Wiley & Sons, Ltd.
A simulation study of IP‐based vertical handoff in wireless convergent networks
Authors: Song Jung Kee , Wang Wenye 
Published: July 2006

AbstractThe advances in wireless networks and IP technologies has brought ubiquitous access to all‐IP information into reality. For wireless IP services, IP‐based handoff is a critical issue to the performance of application‐level services. Although mobile IP (MIP) and its extensions, as network layer solutions, have been proposed asde factostandard, transmission throughput degradation due to packet loss, registration delay, and transport layer blocking are unavoidable because of MIP handoff mechanisms. In this paper, we evaluate the performance of a transport layer handoff approach, mobile stream control transmission protocol (mSCTP), and compare it with that of a network layer solution, MIP. mSCTP is based on stream control transmission protocol (SCTP), which is the third general purpose transport layer protocol from IETF. We investigate the use of mSCTP forseamless vertical handoffwithout any change in IP protocol stack by its multi‐homing feature and dynamic address reconfiguration (DAR) extension. We evaluate the performance of mSCTP and MIP by introducing handoff delay, end‐to‐end transmission throughput, and packet loss, and verify our observations by a simulation study of the two protocols in UMTS/802.11b integrated networks using NS‐2 network simulator. Copyright © 2006 John Wiley & Sons, Ltd.
F‐PCM: a fragmentation‐based power control MAC protocol for IEEE 802.11 mobile ad hoc networks
Authors: Kim Dongkyun , Toh C. K. 
Published: July 2006

AbstractA great deal of research has been directed toward reducing energy consumption at the 802.11‐based MAC layer for mobile ad hoc networks (MANETs). There exists an approach that uses maximum power during the RTS‐CTS exchange and computes the required amount of power in order for DATA and ACK messages to reach the receiver and sender. It, however, does not consider the existence of an interference range (IR), or often called a carrier sensing zone. In order to address the problem, an existing approach forces nodes, located within a sender's carrier sensing zone, to defer their transmission trials in order to avoid collisions at the sender. It, however, does not consider possible collisions at the receiver, which can result in frequent retransmissions and hence greater energy consumption. Therefore, we propose an efficient protocol called Fragmentation‐based Power Control MAC (F‐PCM), which utilizes the fragmentation mechanism of the IEEE 802.11 MAC protocol so as to avoid collisions at senders as well as those at receivers. Through extensive simulations, our F‐PCM has performed better in terms of providing a higher throughput and incurring lower energy consumption. This is particularly advantageous in a dense mobile network environment where collisions are more severe. Copyright © 2006 John Wiley & Sons, Ltd.
Blood‐brain barrier transport of amino acids in healthy controls and in patients with phenylketonuria
Authors: Knudsen G. M. , Hasselbalch S. , Toft P. B. , Christensen E. , Paulson O. B. , Lou H. 
Published: July 2006

SummaryBlood‐brain barrier permeability to phenylalanine and leucine in four patients with phenylketonuria and in four volunteers was measured five times by the double‐indicator method at increasing plasma concentrations of phenylalanine. Based on the permeability‐surface area product (PS) from blood to brain (PS1) and on plasma phenylalanine levels, Vmax and the apparentKm for phenylalanine were determined.Statistically significant relationships between plasma phenylalanine and PS1 were established in three out of four volunteers, the averageVmax value being 46.7 nmol/g per min and the apparentKm 0.328 mmol/L. Owing to saturation of the carrier, such a relationship could not be established in the patients.In phenylketonuria, PS1 for phenylalanine and leucine decreased significantly by 55% and 46%, respectively. Transport from brain back to blood, PS2, decreased significantly and cerebral large neutral amino acid net uptake was generally decreased in patients with phenylketonuria.In conclusion, the transport ofl‐phenylalanine across the human blood‐brain barrier follows Michaelis‐Menten kinetics. In phenylketonuria, brain permeability to large neutral amino acids is reduced by about 50% and net uptake appears decreased.
Non‐ketotic hyperglycinaemia presenting as pachygyria
Authors: Fletcher J. M. , Bye A. M. E. , Nayanar V. , Wilcken B. 
Published: July 2006

SummaryA 2‐day‐old infant with lethargy and hypoventilation had pachygyria and agenesis of the corpus callosum on CT scand. Increased concentrations of glycine in plasma and CSF, together with an increased CSF/plasma ratio, confirmed a clinical diagnosis of non‐ketotic hyperglycinaemia. This is the first report of pachygyria in this disorder, although agenesis of the corpus callosum is well recognized, and non‐specific gyral malformations have been described previously. The specific diagnosis of an inborn error of metabolism in infants with structural brain malformations is of critical importance for accurate genetic counselling.
Identification ofN‐acetyl‐S‐(3‐oxo‐3‐carboxy‐n‐propyl)cysteine in the urine of a patient with cystathioninuria using LC/APCI‐MS
Authors: Zhang J. , Masuoka N. , Ubuka T. , Sugahara K. , Kodama H. 
Published: July 2006

SummaryA new cystathionine metabolite has been identified in the urine of a patient with cystathioninuria using liquid chromatography‐mass spectrometry with an atmospheric pressure chemical ionization interface system (LC/APCI‐MS). By this method a very intense quasi‐molecular ion was observed as a base peak of syntheticN‐acetyl‐S‐(3‐oxo‐3‐carboxy‐n‐propyl)cysteine (NAc‐OCPC). The quasimolecular ion [M+H]+ of NAc‐OCPC observed in the urine of a patient with cystathioninuria was the same as that of the authentic compound (m/z 264). The retention time andRf value on paper chromatography of the synthetic compound were the same as those of the urinary compound from the patient with cystathioninuria. From these results, this new cystathionine metabolite was identified asN‐acetyl‐S‐(3‐oxo‐3‐carboxy‐n‐propyl)cysteine.
Clinical, biochemical, and molecular analysis of a maternally inherited case of Leight syndrome (MILS) associated with the mtDNA T8993G point mutation
Authors: Degoul F. , Diry M. , Rodriguez D. , Robain O. , François D. , Ponsot G. , Marsac C. , Desguerre I. 
Published: July 2006

SummaryWe report a new case of Leigh disease (subacute necrotizing encephalomyelopathy) in a girl with mitochondrial DNA (mtDNA) mutation in the ATPase6 gene at nucleotide position 8993. Sequence analysis of mtDNA revealed a T‐to‐G transversion at nucleotide position 8993 in the ATPase6 gene. Southern blot restriction analysis of patient muscle mtDNA showed only a mutant pattern for the mutation 8993. Molecular analysis of seven subjects from the family showed that except for the father they all carried the 8993 mtDNA mutation in all studied tissues, with high percentages in the two symptomatic children and even in one asymptomatic boy.
Elevated plasma chitotriosidase activity in various lysosomal storage disorders
Authors: Guo Yufeng , He Wang , Boer A. M. , Wevers R. A. , de Bruijn A. M. , Groener J. E. M. , Hollak C. E. M. , Aerts J. M. F. G. , Galjaard H. , van Diggelen O. P. 
Published: July 2006

SummaryRecently a striking elevation of the activity of chitotriosidase, an endo β‐glucosaminidase distinct from lysozyme, was found in plasma from patients with Gaucher type I disease (McKusick 230800). Plasma chitotriosidase originates from activated macrophages and this elevation is secondary to the basic defect in Gaucher disease. To investigate the specificity of this phenomenon, we have investigated 24 different lysosomal storage diseases. In 11 different diseases increased chitotriosidase activity in plasma was found (in 28% of the patients). None of these diseases showed elevations as high as in Gaucher disease. Chitotriosidase was not significantly elevated in plasma from 20 different non‐lysosomal enzymopathies or in plasma from patients with infectious diseases associated with hepatomegaly. The results show that marked elevation of chitotriosidase activity in plasma appears to be specific for Gaucher disease. The data further suggest that elevated levels of chitotriosidase activity in plasma from patients with unexplained diseases may be indicative for a lysosomal disorder.
Race and the Politics of Memory: Mark Twain and Paul Laurence Dunbar
Authors: FISHKIN SHELLEY FISHER 
Published: July 2006

In an 1899 essay Mark Twain wrote,It would not be possible for a humane and intelligent person to invent a rational excuse for slavery; yet you will remember that in the early days of the emancipation agitation in the North the agitators got but small help or countenance from any one. Argue and plead and pray as they might, they could not break the universal stillness that reigned, from pulpit and press all the way down to the bottom of society – the clammy stillness created and maintained by the lie of silent assertion – the silent assertion … that nothing is going on which fair and intelligent men are aware of and are engaged by their duty to try to stop.
Guantánamo, Eatonville, Accompong: Barbecue and the Diaspora in the Writings of Zora Neale Hurston
Authors: WARNES ANDREW 
Published: July 2006

African American writers often express great affection for barbecue, a food many describe as “scrumptious” – to use a term that recurs throughout Bobby Seale's cookbook, Barbeque'n with Bobby (1988) – and invest with a particular capacity to lend shape and coherence to the idea of the African Diaspora. In the writings of Ntozake Shange, Albert Murray, Alice Walker, and others, barbecue seems able to reunite black communities, to gather together people dispersed across the USA or even the world. This literary use of barbecue is epitomized by Alice Walker's The Color Purple (1982), the concluding pages of which make the food central to a rejuvenating Diasporic optimism that stands in sharp contrast to the novel's desolate opening description of Celie's sexual abuse. Having grown up in West Africa, Adam, offspring of Celie's rape, finally meets his mother at a barbecue held in the American South. The food provides a conversation opener, a point of contact that the estranged family badly need:Everybody make a lot of miration over Tashi. People look at her and Adam's scars like that's they business. Say they never suspect African ladies could look so good. They make a fine couple. Speak a little funny, but us gitting use to it.
Reading comprehension in children with specific language impairment: an examination of two subgroups
Authors: Kelso Katrina , Fletcher Janet , Lee Penny 
Published: July 2006

AbstractBackground: In reading research, children with specific language impairment (SLI) have tended to be included in groups of children expected to have difficulties with both decoding and reading comprehension (generally poor readers). This is because generally children with specific language impairment display difficulties with phonology as well as syntax and/or semantics. However, children with specific language impairment are a heterogeneous group. Many children with specific language impairment have oral comprehension difficulties that are likely to limit reading comprehension. A subgroup of these children may exhibit intact phonological and decoding skills. If so, they would resemble the children with specific reading comprehension difficulties (poor comprehenders) reported in the literature.Aims: This study sought to identify a group of children with a poor comprehender reading profile amongst children with specific language impairment. It then compared the phonological and oral comprehension skills of the group of 15 poor comprehenders with a group of 15 generally poor readers with specific language impairment, to identify any differences in language skills. Secondarily, the study wanted to determine which of the language tasks best predicted group membership.Methods & Procedures: The study was carried out in two phases. In Phase 1, children with specific language impairment were assessed on the Woodcock Word Attack to identify a group with adequate decoding skills. These children had poor reading comprehension on the Neale Analysis of Reading Ability. From the poor decoders on the Word Attack, a second group of children, matched for age and gender, was selected to form the generally poor reader group. In Phase 2, the participants were assessed on a battery of phonological and oral comprehension tasks.Outcomes & Results: A group of children exhibiting a poor comprehender reading profile was found to exist amongst children with specific language impairment. As expected, the poor comprehenders performed significantly better than the generally poor readers on phonological awareness tasks. On the oral comprehension tasks, the two groups did not differ at the word and sentence level; however, the poor comprehenders had significantly weaker oral comprehension skills at the paragraph level.Conclusions: This study found that children with specific language impairment, who have equally poor reading comprehension but which differ in their decoding ability, differ not only in their performance on phonological tasks, but also on oral comprehension at the paragraph level. This indicates a need for paragraph‐level oral comprehension to be included in assessment. In addition, educational and clinical intervention programmes for children with specific language impairment should ensure that they are meeting individual needs.
Inferring Functional Pathways from Multi-Perturbation Data
Authors: Yosef Nir , Kaufman Alon , Ruppin Eytan 
Published: July 2006

Abstract
Background: Recently, a conceptually new approach for analyzing gene networks, the Functional Influence Network (FIN) was presented. The FIN approach uses the measured performance of a given cellular function under different multi-perturbations, to identify the main functional pathways and interactions underlying its processing. Here we present and study an iterative, extended version of FIN, the Functional Influence Network Extractor (FINE), which is specifically geared towards the accurate analysis of sparse cellular systems. We employ it to study a conceptually fundamental question of practical importance—how well should we know the system studied (such that we can predict its performance) so that we can understand its workings (i.e., chart its underlying functional network)?
Results and Conclusions: The performance of FINE is studied in both simulated and biological sparse systems. It successfully obtains an accurate and compact description of the underlying functional network even with limited data, and outperforms FIN. We show that prior estimates of a system's functional complexity are instrumental in determining how much predictive knowledge is required to accurately chart its underlying functional network.
Availability: The FINE software is available for download at
Contact: niryosef@post.tau.ac.il
ZPRED: Predicting the distance to the membrane center for residues in α-helical membrane proteins
Authors: Granseth Erik , Viklund Håkan , Elofsson Arne 
Published: July 2006

Abstract
Motivation: Prediction methods are of great importance for membrane proteins as experimental information is harder to obtain than for globular proteins. As more membrane protein structures are solved it is clear that topology information only provides a simplified picture of a membrane protein.
Here, we describe a novel challenge for the prediction of α-helical membrane proteins: to predict the distance between a residue and the center of the membrane, a measure we define as the Z–coordinate.
Even though the traditional way of depicting membrane protein topology is useful, it is advantageous to have a measure that is based on a more “physical” property such as the Z–coordinate, since it implicitly contains information about re-entrant helices, interfacial helices, the tilt of a transmembrane helix and loop lengths.
Results: We show that the Z–coordinate can be predicted using either artificial neural networks, hidden Markov models or combinations of both. The best method, ZPRED, uses the output from a hidden Markov model together with a neural network. The average error of ZPRED is 2.55Å and 68.6% of the residues are predicted within 3Å of the target Z–coordinate in the 5–25Å region. ZPRED is also able to predict the maximum protrusion of a loop to within 3Å for 78% of the loops in the dataset.
Availability: Supplementary information and training data is available at
Contact: arne@bioinfo.se
Protein classification using ontology classification
Authors: Wolstencroft K. , Lord P. , Tabernero L. , Brass A. , Stevens R. 
Published: July 2006

Abstract
Motivation: The classification of proteins expressed by an organism is an important step in understanding the molecular biology of that organism. Traditionally, this classification has been performed by human experts. Human knowledge can recognise the functional properties that are sufficient to place an individual gene product into a particular protein family group. Automation of this task usually fails to meet the ‘gold standard’ of the human annotator because of the difficult recognition stage. The growing number of genomes, the rapid changes in knowledge and the central role of classification in the annotation process, however, motivates the need to automate this process.
Results: We capture human understanding of how to recognise members of the protein phosphatases family by domain architecture as an ontology. By describing protein instances in terms of the domains they contain, it is possible to use description logic reasoners and our ontology to assign those proteins to a protein family class.
We have tested our system on classifying the protein phosphatases of the human and Aspergillus fumigatus genomes and found that our knowledge-based, automatic classification matches, and sometimes surpasses, that of the human annotators. We have made the classification process fast and reproducible and, where appropriate knowledge is available, the method can potentially be generalised for use with any protein family.
Availability: All components described in this paper are freely available.
OWL ontology
myGrid
Instance Store
Contact: KWolstencroft@cs.man.ac.uk