bluuebunny/crossref_metadata_2025_split huggingface dataset:
SOSIALISASI DAN EDUKASI BAHAYA ANEMIA DAN PENGGUNAAN TABLET PENAMBAH DARAH (Fe) PADA SISWA DI SMA NEGERI 2 KENDARI
Authors: Sabarudin  , Rifa'atul Mahmudah  , Loly Subhiaty Idrus  , Sitti Raodah Nurul Jannah  , Nurull Hikmah  , Rachma Malina  , Fifi Nirmala  
Published: March 2024

SMA Negeri (SMAN) 2 Kendari merupakan salah satu Sekolah Menengah Atas Negeri yang ada di Kota Kendari Provinsi Sulawesi Tenggara, Indonesia yang terletak di Jln. Sisingamangaraja no 41, Poasia, Kota Kendari, dan telah mengantongi akreditasi A. Total keseluruhan peserta didik pada sekolah ini sebesar 1.389 siswa, 81 guru, 4 tendik dan 4 PTK. Jumlah siswa yang cukup banyak di sekolah tersebut dianggap layak mewakili remaja di kota Kendari untuk dilakukan penyuluhan mengenai bahaya anemia dan penggunaan tablet tambah darah. Terutama, karena remaja dianggap masih minim pengetahuan mengenai anemia. Anemia terjadi karena defisiensi zat besi. Kejadian paling sering dialami oleh siswi remaja dalam periode menstruasi. Pada siswa sekolah anemia dapat meyebabkan penurunan konsentrasi dan menurunnya daya tangkap terhadap Pelajaran. Gejala anemia seperti Lelah,lelah, lesu muka pucat dan penurunan konsentrasi adalah beberapa bahaya yang ditimbulkan akibat defisiensi zat besi. Selain itu, efek jangka Panjang seperti gagal jantung kongestif, penyakit infeksi kuman, thalasemia, gangguan sistem imun, dan meningitis jika tidak diobati dalam waktu yang lama. Tujuan dari program kemitraan masyarakat ini adalah untuk mengedukasi bahaya anemia dan penggunaan tablet tambah darah pada siswa SMAN 2 kendari dengan metode caramah dan pembagian leaflet. Siswa yang telah menerima materi terkat anemia dan tablet tambah darah meningalami peningakatan pengetahuan sebesar setelah diedukasi sehingga dapat meningkatkan kesehatan tubuh dan menghasilkan generasi muda yang lebih sehat.
Diabetes in spotlight: current knowledge and perspectives of photobiomodulation utilization
Authors: Perrier Quentin , Moro Cécile , Lablanche Sandrine 
Published: March 2024

IntroductionDiabetes is a global health concern characterized by chronic hyperglycemia resulting from insulinopenia and/or insulin resistance. The rising prevalence of diabetes and its associated complications (ulcers, periodontitis, healing of bone defect, neuropathy, retinopathy, cardiopathy and nephropathy) necessitate innovative therapeutic approaches. Photobiomodulation (PBM), involves exposing tissues and cells to low-energy light radiation, leading to biological effects, largely via mitochondrial activation.MethodsThis review evaluates preclinical and clinical studies exploring the potential of PBM in diabetes and its complications, as well all clinical trials, both planned and completed, available on ClinicalTrials database.ResultsThis review highlights the variability in PBM parameters across studies, hindering consensus on optimal protocols. Standardization of treatment parameters and rigorous clinical trials are needed to unlock PBM’s full therapeutic potential. 87 clinical trials were identified that investigated PBM in diabetes mellitus (with 5,837 patients planned to be treated with PBM). Clinical trials assessing PBM effects on diabetic neuropathy revealed pain reduction and potential quality of life improvement. Studies focusing on wound healing indicated encouraging results, with PBM enhancing angiogenesis, fibroblast proliferation, and collagen density. PBM’s impact on diabetic retinopathy remains inconclusive however, requiring further investigation. In glycemic control, PBM exhibits positive effects on metabolic parameters, including glucose tolerance and insulin resistance.ConclusionClinical studies have reported PBM-induced reductions in fasting and postprandial glycemia without an increased hypoglycemic risk. This impact of PBM may be related to its effects on the beta cells and islets in the pancreas. Notwithstanding challenges, PBM emerges as a promising adjunctive therapy for managing diabetic neuropathy, wound healing, and glycemic control. Further investigation into its impact on diabetic retinopathy and muscle recovery is warranted.
Exploring the bidirectional relationship between metabolic syndrome and thyroid autoimmunity: a Mendelian randomization study
Authors: Chen Kefan , Sun Wei , He Liang , Dong Wenwu , Zhang Dalin , Zhang Ting , Zhang Hao 
Published: March 2024

BackgroundObservational studies have reported a possible association between metabolic syndrome (MetS) and thyroid autoimmunity. Nevertheless, the relationship between thyroid autoimmunity and MetS remains unclear. The objective of this research was to assess the causal impact of MetS on thyroid autoimmunity through the utilization of Mendelian randomization (MR) methodology.MethodsWe performed bidirectional MR to elucidate the causal relationship between MetS and their components and thyroid autoimmunity (positivity of TPOAb). Single nucleotide polymorphisms (SNPs) of MetS and its components were obtained from the publicly available genetic variation summary database. The Thyroidomics Consortium conducted a genome-wide association analysis, which provided summary-level data pertaining to thyroid autoimmunity. The study included several statistical methods, including the inverse variance weighting method (IVW), weighted median, simple mode, weight mode, and MR-Egger methods, to assess the causal link. In addition, to ensure the stability of the results, a sensitivity analysis was conducted.ResultsIVW showed that MetS reduced the risk of developing thyroid autoimmunity (OR = 0.717, 95% CI = 0.584 - 0.88, P = 1.48E−03). The investigation into the causative association between components of MetS and thyroid autoimmune revealed a statistically significant link between triglycerides levels and the presence of thyroid autoimmunity (IVW analysis, OR = 0.603, 95%CI = 0.45 -0.807, P = 6.82E−04). The reverse analysis did not reveal any causal relationship between thyroid autoimmunity and MetS, including its five components.ConclusionsWe have presented new genetic evidence demonstrating that MetS and its triglyceride components may serve as potential protective factors against thyroid autoimmunity.
Anaerobic biodegradation of brown grease and its potential as a source of renewable energy
Authors: Heindel Amy , Lee Ross , Spracklin Dan , Duran Metin 
Published: March 2024

The purpose of the study was twofold. The first was to study the anaerobic digestibility and the biochemical methane potential (BMP) of brown grease (BG)–fats and oils collected from restaurants and similar food production facilities. The second objective was to investigate the effects of adding dry, food waste derived hydrochar to enhance the digestion process, specifically as a possible in situ agent to improve biogas quality. The BMP tests involved various BG loadings between 3 and 30 g BG/L. The results indicate that BG is highly digestible under anaerobic conditions with 354 mL CH4/g COD equivalent of BG at 1 atm and 35°C testing conditions, which translates into 28 million gasoline gallon equivalent (GGE) potential energy that could be recovered by anaerobically digesting or co-digesting BG. The particular hydrochar investigated in this study did not show any potential to increase biogas CH4 content.
“…He’s not beating me”—Socio-cultural construction of intimate partner violence and traditional birth attendants: implications for maternal & child health in rural communities in Hohoe, Ghana
Authors: Okoror Titilayo A. , Nyamuame Bless M. , Martin-Ikpe Cordelia , Gilani Yasmeen , Nyamuame Samuel Elikem 
Published: March 2024

IntroductionMost research on Intimate Partner Violence (IPV) focuses on the physical, sexual and psychological abuse, with less focus on the financial abuse. This study explores nursing mothers' experiences and perceptions of financial and material support from their significant others and traditional birth attendants' (TBA) observations of support to nursing mothers in their communities.MethodsUsing purposive sampling, focus groups and interviews were conducted primarily in Ewe language among nursing mothers and TBAs in rural communities in Hohoe, Volta region, Ghana. All discussions were audio-recorded and transcribed for analysis. Thematic analysis guided by the social constructivist framework was used in data analysis.ResultsTwenty-seven women participated in the study, ranging in ages from 19 to 82 (20 nursing mothers; 7 TBAs). Most participants were married (19) and about 65% reported working outside the home (10 nursing mothers; 7 TBAs). Two themes emerged from the data analysis: Lack of support from partners for housekeeping chores and finances; and TBAs as mediators. Nursing mothers who reported lack of financial support did not perceive it as abuse, rather as hinderance to their efforts to care for their children. TBAs act as mediators interceding on behalf of nursing mothers with their husbands and fathers of their children, while also seeking resources to support them.DiscussionUnderstanding the perceptions and socio-cultural meanings women attached to IPV experience is essential for effective intervention to reduce IPV. In addition, TBAs can be a resource in intervening to alleviate IPV in their communities, thereby improving maternal and child health.
Optimizing PEEK implant surfaces for improved stability and biocompatibility through sandblasting and the platinum coating approach
Authors: Faadhila Afrah , Taufiqurrakhman Mohamad , Katili Puspita Anggraini , Rahman Siti Fauziyah , Lestari Delly Chipta , Whulanza Yudan 
Published: March 2024

Polyether–ether–ketone (PEEK) is a commonly employed biomaterial for spinal, cranial, and dental implant applications due to its mechanical properties, bio-stability, and radiolucency, especially when compared to metal alloys. However, its biologically inert behavior poses a substantial challenge in osseointegration between host bone and PEEK implants, resulting in implant loosening. Previous studies identified PEEK surface modification methods that prove beneficial in enhancing implant stability and supporting cell growth, but simultaneously, those modifications have the potential to promote bacterial attachment. In this study, sandblasting and sputter coating are performed to address the aforementioned issues as preclinical work. The aim is to investigate the effects of surface roughness through alumina sandblasting and a platinum (Pt) sputtered coating on the surface friction, cell viability, and bacterial adhesion rates of PEEK material. This study reveals that a higher average surface roughness of the PEEK sample (the highest was 1.2 μm obtained after sandblasting) increases the coefficient of friction, which was 0.25 compared to the untreated PEEK of 0.14, indicating better stability performance but also increased bacterial adhesion. A novelty of this study is that the method of Pt coating after alumina sandblasting is seen to significantly reduce the bacterial adhesion by 67% when compared to the sandblasted PEEK sample after 24 h immersion, implying better biocompatibility without changing the cell viability performance.
Case report: A rare case of bilateral Leber’s idiopathic stellate neuroretinitis
Authors: He Wei , Tang Panli , Lv Hongbin , Qiao Lifeng 
Published: March 2024

BackgroundLeber’s idiopathic stellate neuroretinitis (LISN) is a rare disease characterized by disk edema, peripapillary and macular hard exudates, and often, the presence of vitreous cells. To enhance clinical understanding of the disease, a retrospective analysis was conducted on a patient diagnosed with LISN at our hospital, and discussions were held regarding its diagnosis and treatment.MethodsWe reviewed the medical records of a 26-year-old male patient whose main complaint was a decrease in visual acuity of both eyes for 4 days, which had worsened over the last day. After systemic examination, fundus fluorescein angiography, and indocyanine green angiography, the patient was diagnosed with LISN in both eyes. After treatment with glucocorticoids, the patient’s vision showed a significant improvement.ResultsUpon admission, the visual acuity of both eyes was: VOD 0.05, VOS 0.25. After 5 days of treatment, the visual acuity of both eyes was: VOD 0.25, VOS 0.4. After 1 month of follow-up, the visual acuity of both eyes was: VOD 0.4, VOS 0.6. After 5 months of follow-up, the patient’s vision improved to VOD 0.6, VOS 0.8.ConclusionThe cause of LISN remains unidentified. It is essential to rule out diseases exhibiting similar clinical signs but possessing a clear etiology. The primary treatment approach involves glucocorticoid-based anti-inflammatory therapy, potentially supplemented with antibiotics, antivirals, vasodilators, and traditional Chinese medicine. This disease is usually self-limiting and generally carries a favorable prognosis.
Global research trends and hotspots in patellofemoral pain syndrome from 2000 to 2023: a bibliometric and visualization study
Authors: Xu Jie , Cai Zijuan , Chen Meng , Wang Xin , Luo Xiaobing , Wang Yanjie 
Published: March 2024

BackgroundPatellofemoral pain syndrome (PFPS) is a prevalent condition in sports medicine, and as sports competitions become more popular, the incidence of sports injuries is on the rise. Despite the increasing research on PFPS, there remains a lack of bibliometric analyses on this topic. The aim of this study was to identify the research hotspots and trends in the field of PFPS by reviewing 23 years of literature in this field.MethodsBy analyzing the literature on PFPS research from 2000 to 2023 in the core dataset of the Web of Science database and utilizing bibliometric tools like CiteSpace 6.1, VOSviewer 1.6.18, R-bibliometrix 4.6.1, Pajek 5.16, and Scimago Graphica 1.0.26, our aim was to gain insights into the current status and key areas of PFPS research. The study examined various aspects including the number of publications, countries, institutions, journals, authors, collaborative networks, keywords, and more. Through the visualization of relevant data, we also attempted to forecast future trends in the field.ResultsThere were 2,444 publications were included in this visualization study, published in 322 journals by 1,247 authors from 818 institutions in 67 countries. The Journal of Orthopaedic and Sports Physical Therapy had the highest number of publications, with the USA leading in article count. La Trobe University contributed the most articles, while Rathleff MS and Barton CJ emerged as the most prolific authors. Hip and knee strength and core strength, lower extremity kinematics and biomechanics, females (runners), muscle activation, risk factors, gait retraining, clinical practice guidelines, and rehabilitation were research hotspot keywords.ConclusionCurrent research suggests that there is still significant potential for the development of PFPS research. Key areas of focus include the clinical effectiveness of combined hip and knee strengthening to address PFPS, characterization of lower limb kinematics and biomechanics, gait retraining, risk factors, and clinical practice guidelines. Future research could explore the effectiveness of innovative exercise therapies such as blood flow restricting training, gait retraining, and neuromuscular control training for PFPS improvement. Further investigation into gait retraining for runners, particularly females, and clinical efficacy study of a novel PRP formulation for the treatment of PFPS.
Different fat-to-fiber ratios by changing wheat inclusion level impact energy metabolism and microbial structure of broilers
Authors: Jiang Qiuyu , Zhao Lihua , Ban Zhibin , Zhang Bingkun 
Published: March 2024

IntroductionDietary nutrient content is crucial for energy metabolism and development of gut microbiota. Herein, this study aimed to explore the effects of fat-to-fiber ratios on nutrient transporter, energy metabolism and gut microbiota when ingredients composition was altered.MethodsA total of 240 as-hatched broiler chickens were randomly assigned into three groups including low fat-high dietary fiber (LF-HD), medium fat-medium dietary fiber (MF-MD) and high fat-low dietary fiber (HF-LD), with diets being iso-protein, and broilers were offered the same commercial diets from 21 to 42 d. The data were analyzed using one-way ANOVA of SPSS.Results and DiscussionResults showed that HF-LD diet significantly increased glucose content and decreased triglyceride in serum of broilers (p &lt; 0.05). The mRNA abundance of jejunal gene involved in glucose transporter and tricarboxylic acid (TCA) cycle was significantly increased in broilers fed with HF-LD diets. Compared with LF-HD, HF-LD had a lower abundance of Anaerofilum and CHKCI001, and an increased proportion of beneficial bacteria such as Alistipes, Catenibacillus, Intestinimonas, Lactobacillus, and Peptococcus (p &lt; 0.05). Functional prediction of these microbial changes indicated that HF-LD diet drove caecal microbiota to participate in carbohydrate metabolism and TCA cycle (p &lt; 0.05). Dietary HF-LD-induced microbiota changes were positively correlated with growth performance of broilers (p &lt; 0.05). Therefore, HF-LD diet increased glucose transporters and energy metabolism in intestine and shaped microbial structure and metabolic pathways, which may benefit the growth performance of broilers.
Exploring an innovative decellularization protocol for porcine nerve grafts: a translational approach to peripheral nerve repair
Authors: Muratori Luisa , Crosio Alessandro , Ronchi Giulia , Molinaro Debora , Tos Pierluigi , Lovati Arianna B. , Raimondo Stefania 
Published: March 2024

IntroductionPeripheral nerves are frequently affected by lesions caused by traumatic or iatrogenic damages, resulting in loss of motor and sensory function, crucial in orthopedic outcomes and with a significant impact on patients’ quality of life. Many strategies have been proposed over years to repair nerve injuries with substance loss, to achieve musculoskeletal reinnervation and functional recovery. Allograft have been tested as an alternative to the gold standard, the autograft technique, but nerves from donors frequently cause immunogenic response. For this reason, several studies are focusing to find the best way to decellularize nerves preserving either the extracellular matrix, either the basal lamina, as the key elements used by Schwann cells and axons during the regenerative process.MethodsThis study focuses on a novel decellularization protocol for porcine nerves, aimed at reducing immunogenicity while preserving essential elements like the extracellular matrix and basal lamina, vital for nerve regeneration. To investigate the efficacy of the decellularization protocol to remove immunogenic cellular components of the nerve tissue and to preserve the basal lamina and extracellular matrix, morphological analysis was performed through Masson’s Trichrome staining, immunofluorescence, high resolution light microscopy and transmission electron microscopy. Decellularized porcine nerve graft were then employed in vivo to repair a rat median nerve lesion. Morphological analysis was also used to study the ability of the porcine decellularized graft to support the nerve regeneration.Results and DiscussionThe decellularization method was effective in preparing porcine superficial peroneal nerves for grafting as evidenced by the removal of immunogenic components and preservation of the ECM. Morphological analysis demonstrated that four weeks after injury, regenerating fibers colonized the graft suggesting a promising use to repair severe nerve lesions. The idea of using a porcine nerve graft arises from a translational perspective. This approach offers a promising direction in the orthopedic field for nerve repair, especially in severe cases where conventional methods are limited.
Prediction of tissue outcome in acute ischemic stroke based on single-phase CT angiography at admission
Authors: Palsson Frosti , Forkert Nils D. , Meyer Lukas , Broocks Gabriel , Flottmann Fabian , Maros Máté E. , Bechstein Matthias , Winkelmeier Laurens , Schlemm Eckhard , Fiehler Jens , Gellißen Susanne , Kniep Helge C. 
Published: March 2024

IntroductionIn acute ischemic stroke, prediction of the tissue outcome after reperfusion can be used to identify patients that might benefit from mechanical thrombectomy (MT). The aim of this work was to develop a deep learning model that can predict the follow-up infarct location and extent exclusively based on acute single-phase computed tomography angiography (CTA) datasets. In comparison to CT perfusion (CTP), CTA imaging is more widely available, less prone to artifacts, and the established standard of care in acute stroke imaging protocols. Furthermore, recent RCTs have shown that also patients with large established infarctions benefit from MT, which might not have been selected for MT based on CTP core/penumbra mismatch analysis.MethodsAll patients with acute large vessel occlusion of the anterior circulation treated at our institution between 12/2015 and 12/2020 were screened (N = 404) and 238 patients undergoing MT with successful reperfusion were included for final analysis. Ground truth infarct lesions were segmented on 24 h follow-up CT scans. Pre-processed CTA images were used as input for a U-Net-based convolutional neural network trained for lesion prediction, enhanced with a spatial and channel-wise squeeze-and-excitation block. Post-processing was applied to remove small predicted lesion components. The model was evaluated using a 5-fold cross-validation and a separate test set with Dice similarity coefficient (DSC) as the primary metric and average volume error as the secondary metric.ResultsThe mean ± standard deviation test set DSC over all folds after post-processing was 0.35 ± 0.2 and the mean test set average volume error was 11.5 mL. The performance was relatively uniform across models with the best model according to the DSC achieved a score of 0.37 ± 0.2 after post-processing and the best model in terms of average volume error yielded 3.9 mL.Conclusion24 h follow-up infarct prediction using acute CTA imaging exclusively is feasible with DSC measures comparable to results of CTP-based algorithms reported in other studies. The proposed method might pave the way to a wider acceptance, feasibility, and applicability of follow-up infarct prediction based on artificial intelligence.
Guideline for standardized approach in the treatment of the Mal de Debarquement syndrome
Authors: Schoenmaekers Catho , Jillings Steven , De Laet Chloë , Zarowski Andrzej , Wuyts Floris L. 
Published: March 2024

IntroductionMal de Debarquement Syndrome (MdDS) is a debilitating neuro-otological disorder. Patients experience almost continuously a perception of self-motion. This syndrome can be motion-triggered (MT-MdDS), such as on a boat, or occur spontaneously or have other triggers (SO-MdDS) in the absence of such motion. Because the pathophysiological mechanism is unknown, treatment options and symptom management strategies are limited. One available treatment protocol involves a readaptation of the vestibular ocular reflex (VOR). This study assesses the effectiveness of vestibulo-ocular reflex (VOR) readaptation in 131 consecutive patients with a fixed protocol.MethodsWe administered 131 treatments involving optokinetic stimulation (OKS) paired with a fixed head roll at 0.167 Hz over two to five consecutive days. Each day, four-minute treatment blocks were scheduled twice in the morning and afternoon. Treatment effectiveness was evaluated through questionnaires and posturography.ResultsWe observed significant improvements in the visual analog scale (VAS), MdDS symptom questionnaire, and posturography measures from pre- to post-treatment. No significant differences were found in outcome variables between MT- and SO-MdDS onsets.ConclusionSymptoms improved subjectively and objectively in patients’ post-treatment. The overall success rate was 64.1%, with no significant difference between MT (64.2%) and SO (63.3%). This study supports the conclusion that VOR readaptation treatment provides relief for two-thirds of MdDS patients, irrespective of the onset type. Based on consistency in the findings, we propose a standardized method for treatment of MdDS based on the OKS with head roll paradigm.