bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eco‐friendly green synthesis of Ag@Cu bimetallic nanoparticles: Evaluation of their structural, morphological and electrochemical characterizations
Authors: Shareef Shaik Nagul , Bhavani Kalli Sai , Anusha Tummala , Priyanka Pallapati , Rao M. Subba 
Published: March 2024

AbstractThe present study focuses on the preparation of silver/copper bimetallic hybrid nanoparticles by green method from precursor solutions of silver nitrate & copper nitrate and the locally available citrus fruit (lemon) peel extract which behaves as the stabilizing and reducing agent. Initially, the formation of hybrid nanoparticles was noticed in the reaction mixture by colour change. Here, UV‐Visible spectroscopy is useful to examine the optical measurements of the prepared nanoparticles and it exhibited the maximum absorption wavelength for lemon peel extract at 440 nm. Later, the functional groups present in the synthesized nanoparticles are investigated by FT‐IR spectroscopy. In addition, the pure and crystalline nature of developed nanoparticles was evaluated by XRD measurements. The spherical shape of produced bimetallic hybrid nanoparticles was observed by SEM analysis. The elemental composition of the synthesized nanoparticles was investigated by EDX analysis. Furthermore, electrochemical evaluation of synthesized nanoparticles by usage of CV (cyclic voltammetry) exhibited that Ag@Cu bimetallic NPs were highly electroactive than other electrodes. Thus, this newly approached method is simple, rapid, inexpensive, and environmentally friendly and this green method proves an alternative to physiochemical methods for the preparation of nanoparticles.
Phenolic constituents from Elsholtzia ciliata (Thunb.) Hyland and their NO production inhibition activity
Authors: Dung Duong Thi , Thao Tran Thi Phuong , Hoang Nguyen Huy , Tai Bui Huu , Van Kiem Phan 
Published: March 2024

AbstractElsholtzia ciliata (Thunb.) Hyl. (Elsholtzia cristata (Willd.), Lamiaceae is a medicinal and spice plant widely used in Vietnam. Phytochemical study on this plant led to the isolation of eleven phenolic glycosides compounds, kaempferol‐3‐β‐D‐(6‐O‐trans‐p‐coumaroyl) glucopyranoside (tiliroside, 1), rosmarinic acid methyl ester (2), 3‐O‐β‐D‐glucopyranosyl‐1‐(3′, 5′‐dimethoxy‐4‐hydroxyphenyl‐1‐propanone) (3), β‐hydroxypropiovanillone 3‐O‐β‐D‐glucopyranoside (4), 4‐(3',4'‐dihydroxyphenyl)‐butan‐2‐one 3'‐O‐β‐D‐glucopyranoside (5), 4‐(3'‐glucopyranosyloxy‐hydroxyphenyl)‐(E)‐3‐buten‐2‐one (6), syringin (7), icariside F2 (8), methyl salicylate α‐L‐arabinopyranosyl‐(1→6)‐β‐D‐glucopyranoside (9), methyl 2‐O‐β‐D‐glucopyranosyl benzoate (10), and 1‐O‐caffeoylglycerol (11). Their chemical structures were evidenced by ESIMS, CD, and NMR spectra in comparison with those in the literature. All the isolated compounds were evaluated their NO production inhibition activity on LPS‐activated RAW264.7 cells. Compounds 2, 9, and 10 inhibited NO production with IC50 values of 19.23±1.30, 16.51±1.56, and 13.73±0.95 μM, respectively, compared to that of the positive control of NG‐monomethyl‐L‐arginine acetate (L‐NMMA) with an IC50 value of 32.51±3.70 μM. Whereas, the other compounds showed no activity with the IC50 values over 100 μM.
The chemical composition from the fruits of Pandanus tonkinensis, their NO production inhibitory and lipid peroxidation inhibitory activities
Authors: Trang Dinh Thi Huyen , Trang Pham Thu , Phuong Do Minh , Anh Duong Hong , Anh Ngo Quoc , Van Kiem Phan , Viet Pham Hung 
Published: March 2024

AbstractSeven known compounds, including two neolignans, four lignans, and one flavane were isolated from the methanol extract of Pandanus tonkinenis fruits. Their structures were determined to be ficusal (1), vladinol F (2), medioresinol (3), syringaresinol (4), lariciresinol (5), secoisolariciresinol (6), and luteoliflavan (7) by analysis of MS and NMR data as well as by comparison of their spectral data with those reported in the literature. All compounds were evaluated for NO production inhibitory and lipid peroxidative inhibitory activities. Compounds 5 and 7 showed significant NO production inhibitory with IC50 values of 5.3±0.4 and 7.1±0.4 μM, respectively. Compounds 6 and 7 showed significant lipid peroxidative inhibitory activity with IC50 values of 20.2±1.7 and 26.2±3.6 μM, respectively.
Synthesis, computational drug likeness, DFT studies and in vitro biological activity evaluation of some heteronuclear complexes of functionalized (E)‐2‐(butan‐2‐ylidene) hydrazinecarbothioamide ligand
Authors: Khan Tahmeena , Azad Iqbal , Ahmad Rumana , Raza Saman , Joshi Seema , Khan Abdul Rahman 
Published: March 2024

AbstractThe dinuclear complexes of Schiff bases possess interesting structures and activity spectrum. Five mixed metal complexes of 2‐butanone thiosemicarbazone were prepared and characterized by different spectroscopic techniques. Molecular docking studies were done with the selected proteins. Computational drug likeness prediction was done using automated softwares. Toxicity assessment and Principal Component Analysis (PCA) was done by OSIRIS 4.6.1 and used to assess the toxicity whereas bioactivity scores and physicochemical properties were predicted by Molinspiration 2016.03. Principal Component Analysis (PCA) was performed using Osiris Property Explorer 4.5.1. Molecular docking studies were performed with three proteins. The anticancer activity was tested against MCF‐7, A549 and HepG‐2 cell lines whereas antibacterial activity was tested against two bacterial strains. The melting points of the complexes were >350oC, indicating high thermal stability. Cu‐Zn‐containing complex showed the least binding energy against the three proteins. The bioactivity scores of the complexes were between ‐0.50 and 0.0. Against A549 Cu‐Zn, Co‐Zn and Fe‐Zn containing complexes showed potential activity. Against MCF‐7, Fe‐Cu containing complex had IC50 of 53.5 whereas Co‐Zn containing complex was active against HepG2. Three complexes were active against S. aureus in the tested range. The dinuclear complexes showed potential biological activity as compared to the mononuclear complexes.
Evaluation of biological activity of some pyridine derivatives on perfusion pressure and their interaction with the M2 muscarinic receptor
Authors: Lauro Figueroa‐Valverde , Maria López‐Ramos , Marcela Rosas‐Nexticapa , Magdalena Alvarez‐Ramirez , Francisco Díaz‐Cedillo , Tomas Lopez‐Gutierrez 
Published: March 2024

AbstractThe aim of this study was to evaluate the biological activity of some pyridine derivatives (compounds 1 to 15) on perfusion pressure in an isolated rat heart model. Furthermore, theoretical interaction of pyridine derivatives with the M2 muscarinic receptor was determined using acetylcholine, AF‐DX 116 and the 3uon protein as theoretical tools in a docking model. Results showed that pyridine derivatives 6, 9, and 13 decreased perfusion pressure compared to control conditions and compounds 1‐5, 7, 8, 10‐12, 14, and 15. Furthermore, theoretical data indicates that different amino acid residues are involved in the interaction of pyridine derivatives with the protein surface. Other data indicate that the inhibition constant was lower for compounds 6, 9 and 13 compared to acetylcholine and AF‐DX 116. In conclusion, all these data suggest that pyridine derivatives 6, 9 and 13 can produce changes in perfusion pressure possibly through activation of the M2 muscarinic receptor, and this phenomenon could depend on the different functional groups involved in its chemical structure.
Fabrication and characterization of polyvinyl alcohol/TiO2membrane immersed in simulated body fluid for biomedical application
Authors: Nguyen Dien Thi My , Huynh Khanh Do Gia , Nguyen Thuy Thanh Doan , Huynh Vu Tan , Nguyen Phuong Tuyet , Nguyen Linh Thuy Ba 
Published: March 2024

AbstractIn this study, we synthesized hydroxyapatite (HA) on polyvinyl alcohol/TiO2(PVA/TiO2) in which TiO2was prepared by the sol‐gel method. HA was formed by immersing the membrane in the simulated body fluid (SBF) solution. We improved the mechanical strength of the membranes by adding glutaraldehyde (GA) combining with heat treatment to cross‐link the polymer network. In addition, the composition of TiO2crystalline phase, TiO2content in each membrane, and the duration of membrane immersion in SBF solution were investigated. The morphological structures of hydroxyapatite/polyvinyl alcohol/TiO2(HA/PVA/TiO2) membranes were characterized by IR, SEM, and XRD. We confirmed that the HA formation depended on the TiO2content and phase composition (rutile or anatase). Membranes containing TiO2rutile‐phase showed more pronounced HA formation than membranes containing TiO2anatase‐phase. The appearance of HA also depended on SBF immersion duration. Membranes soaked for 3 weeks showed significantly more HA formation than membranes soaked for 1 and 2 weeks. Furthermore, the number of cells in membranes soaked for 3 weeks was clearly higher than in other membranes. Finally, HA/PVA/TiO2membranes containing 25 wt.% of TiO2rutile‐phase are biocompatible based on the number of viable cells and thus have the potential for biomedical application.
Some epoxylignans from the Vietnamese propolis of stingless Bee Trigona minor and their bioactivities
Authors: Nguyen Hai Xuan , Nguyen Mai Thanh Thi , Nguyen Nhan Trung 
Published: March 2024

AbstractTwo new epoxylignans, trigonan A (1) and trigonan B (2), were isolated from EtOAc extract of Vietnamese stingless bee propolis Trigona minor (Meliponini, Apidae), together with 15 known compounds. Their chemical structures were determined by extensive NMR and MS spectroscopic analysis. All compounds were tested for DPPH free radical scavenging activity; as a result, methoxylariciresinol (14) showed the best significant DPPH inhibitory activity with IC50 value of 3.0 μM, and had stronger activity than that of a positive control, trolox (IC50, 8.2 μM). In the α‐glucosidase inhibitory activity, syringaresinol (10) displayed the best activity with IC50 value of 17.8 μM, and its activity was more than a positive control, acarbose (IC50, 185.2 μM). For the cytotoxic activity against the HeLa cell line, de‐4'‐O‐methyleudesmin (7) exhibited the most cytotoxicity with IC50 value of 46.3 μM and was quite weaker than that of a positive control, paclitaxel (IC50, 0.0014 μM).
Synthesis of novel nitrogen‐phosphorus flame retardants and their flameproof to flammable polymers
Authors: Nguyen Cong Tranh , Kim Jinhwan 
Published: March 2024

AbstractTo prepare the efficiently flame retardants (FR) for the highly flammable polymers, the novel nitrogen‐phosphorus based FRs (P‐N FR) (PN‐3, PN‐4, PN‐5, and PN‐6) were prepared via phosphorus halides and amine derivatives with 40‐90 % in yields. The appearances of P‐N FRs are lightly white solid. All P‐N FRs are water‐insoluble and show a melting point above 40 oC. The success of the synthesis was confirmed by NMR analysis. Both 1H and 31P NMR data show clearly the same as the predicted chemical shift signals. The thermal stability behavior of these FRs was studied via TGA analysis. Thermal decomposition occurs in the range of 220‐260oC under N2 gas. The 80% of a mass loss with one step decomposition and 5‐20% of the char residues at 700oC were obtained. The UL‐94 test with self‐extinguishing behavior on ABS and EVA was realized at 20‐25wt% loadings of P‐N FRs. It was observed that the addition of 18‐20 wt% of PN‐5 acquires UL‐94 V‐0 rating for the highly flammable resins (ABS and EVA) whereas to achieve the UL‐94 V‐0 rating, 20‐30 wt% of loadings of PN‐4 and PN‐6 are needed. It was concluded that the structure moieties of P‐N FR affect its FR behaviors.
Synthesis and characterization of bimetallic Ni‐Cu‐BDC from waste plastic as a highly efficient CO2/N2 selective adsorbent
Authors: Giang Pham Thi Thu , Hoa Vu Thi , Van Ngo Thuy , Quyen Phan Thi , Quang Nguyen Ke , Manh Nguyen Ba 
Published: March 2024

AbstractIn this work, a bimetallic Ni‐Cu‐BDC metal‐organic framework system was developed via solvent thermal approach with using an organic ligand recycled from waste plastic. The physical properties of Cu‐BDC and bimetallic Ni‐Cu‐BDC were characterized by X‐ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X‐ray spectroscopy (EDX) and N2 isotherms adsorption‐desorption (BET). The results have demonstrated the formation of Ni‐Cu‐BDC crystals with a highly porous structure (surface area up to 502 m2/g and pore volume about 0.208 cm3/g) and particle size of 2‐3 μm. Importantly, the Ni‐Cu‐BDC exhibited superior CO2 adsorption capacity of 5.85 mmol/g at 20°C and 1 atm. These findings indicated the potential application of bimetallic MOFs in CO2 capture technologies to fight global warming.
Effect of enzyme – assisted extraction on total polyphenol content and antioxidant capacity from fresh tea leaves (Camellia sinensis)
Authors: Oanh Doan Thi Yen , Hien Ly Thi Minh , Duyen Nguyen Kha , Hieu Nguyen Huu , Dao Dong Thi Anh 
Published: March 2024

AbstractTea leaves contain high concentration of polyphenols, known as bioactive compounds. In order to increase the extraction yield of polyphenol and the antioxidant capacity of the extract from tea leaves, the combination of cellulase, pectinase and protease in enzyme‐assisted extraction was investigated. By using fractional factorial experimental design to study the two‐enzyme assisted extraction of cellulase and pectinase, three factors including solvent/material ratio, pH and hydrolysis time showed significant effects on the extract properties. The highest total polyphenol content obtained adopting the favorable conditions was 185.9 mg GAE/g of dry material at solvent and material ratio of 5.9, hydrolysis pH of 4.4 and hydrolysis time of 36 minutes. In addition, the antioxidant capacity of the extract was determined at 175.9 mg TE/g of dry material at those optimum experimental conditions. In our test of three‐enzyme (cellulase – pectinase – protease) assisted extraction, the extracts were spray‐dried to observe green tea powder. Results indicated that the TPC, AC and the color sensory quality of the green tea powder decreased compared to the two‐enzyme (cellulase – pectinase) assisted extraction.
Considerations for a threatened seabird: The impact of shoreline avian predators on at‐sea marbled murrelets
Authors: Pastran Sonya A. , Lank David B. 
Published: March 2024

AbstractWe tested the influence of on‐shore avian predators on the at‐sea distribution and abundance of marbled murrelets (Brachyramphus marmoratus) during their breeding season in Haida Gwaii, British Columbia, Canada. We conducted a field experiment using deterrent predator decoy kites that mimicked flying bald eagles (Haliaeetus leucocephalus). In the summers of 2018 and 2019, we conducted at‐sea surveys of murrelet distributions along inshore and offshore transects with and without kites flying, and tallied real eagles along the shoreline and fish schools encountered. Kites negatively influenced overall murrelet counts (estimate = −1.19, 95% CI = −1.88 to −0.51), but we did not detect inshore to offshore movements within the study site. Our results indicate murrelet movement out of the study area in response to the kites. Overall murrelet counts were also lower when real eagle counts were higher (estimate = −0.22, 95% CI = −0.35 to −0.09). When kites were flying, a higher proportion of the murrelets remaining along inshore transects were found between rather than adjacent to kite locations (estimate = −1.61, 95% CI = −2.67 to −0.54), indicating avoidance of kites. Since avian predator populations have steadily increased in the past 30 years throughout the murrelet's breeding range, these avoidance effects could create a negative bias in long‐term shoreline count trends. Our findings highlight the importance of considering non‐lethal predator effects on murrelets when conducting at‐sea censuses and constructing conservation plans.
A Review on Binary Alkaline‐Earth Trielides: an Overview of Compositions and Structures, of their Stabilities and Energetics and of Criteria for the Validity of the Zintl‐Concept
Authors: Beck Horst P. 
Published: March 2024

AbstractOmitting alloys with a compositional range we present a compilation of binary alkaline earth trielides AExTRy together with results of DFT calculations to estimate total energies and energies of formation in comparison and to analyse the distribution of charges at the atomic positions in a Bader analysis of the electron density. In a comparison of many structures, we furthermore analyse the effect of bonding on this charge distribution and reflect on the real bonding patterns in comparison with our expectations according to the Zintl concept, and we find mechanisms blocking an electron transfer as favoured by the electronegativity differences. We have subjected a variety of structural parameters together with the DFT results to a Principal Component Analysis to explore their relationship which we describe in the form of correlation matrices and biplots. The Zintl rules turn out to be a very slack guideline in rationalizing the structures of these compounds.
Lipid homeostasis is essential for oogenesis and embryogenesis in the silkworm, Bombyx mori
Authors: Yang Fangying , Xu Xiaoyan , Hu Bo , Zhang Zhongjie , Chen Kai , Yu Ye , Bai Hua , Tan Anjiang 
Published: March 2024

AbstractReproduction, a fundamental feature of all known life, closely correlates with energy homeostasis. The control of synthesizing and mobilizing lipids are dynamic and well-organized processes to distribute lipid resources across tissues or generations. However, how lipid homeostasis is precisely coordinated during insect reproductive development is poorly understood. Here we describe the relations between energy metabolism and reproduction in the silkworm, Bombyx mori, a lepidopteran model insect, by using CRISPR/Cas9-mediated mutation analysis and comprehensively functional investigation on two major lipid lipases of Brummer (BmBmm) and hormone-sensitive lipase (BmHsl), and the sterol regulatory element binding protein (BmSrebp). BmBmm is a crucial regulator of lipolysis to maintain female fecundity by regulating the triglyceride (TG) storage among the midgut, the fat body, and the ovary. Lipidomics analysis reveals that defective lipolysis of females influences the composition of TG and other membrane lipids in the BmBmm mutant embryos. In contrast, BmHsl mediates embryonic development by controlling sterol metabolism rather than TG metabolism. Transcriptome analysis unveils that BmBmm deficiency significantly improves the expression of lipid synthesis-related genes including BmSrebp in the fat body. Subsequently, we identify BmSrebp as a key regulator of lipid accumulation in oocytes, which promotes oogenesis and cooperates with BmBmm to support the metabolic requirements of oocyte production. In summary, lipid homeostasis plays a vital role in supporting female reproductive success in silkworms.
Xanthogranulomatöse Adrenalitis
Authors: Saeger Wolfgang , Luebke Andreas M. , Mekoula S. T. , Pahnke Jörg-Michael 
Published: March 2024

ZusammenfassungEin radiologisch festgestellter Tumor einer 29-jährigen Frau mit Fieber um 39 °C wurde unter dem Verdacht einer Cholezystitis oder eines Leberabszesses operiert, dabei ein solider Tumor in der Nebennierenloge gefunden und reseziert. Die Schnellschnittbefundung ergab keine klare Diagnose bezüglich der Dignität und der Zuordnung. Histologisch zeigte sich, dass der Tumor aus dicht gelagerten großen histiozytenartigen Zellen mit Expression von Vimentin, CD68 und CD163 sowie Negativität für Keratin, Langerin und SMA aufgebaut ist. Wir diagnostizierten eine xanthogranulomatöse Adrenalitis und diskutierten die Differentialdiagnosen (Langerhans-Zellhistiozytose, Rosai-Dorfman-Krankheit, Malakoplakie, Erdheim-Chester-Krankheit).
Barriers and facilitators in diagnosing axial spondyloarthritis: a qualitative study
Authors: Hay Charles A. , Packham Jon , Prior James A. , Mallen Christian D. , Ryan Sarah 
Published: March 2024

Abstract
Introduction
Diagnosis of axial spondyloarthritis (axSpA) is frequently delayed for years after symptom onset. However, little is known about patient and healthcare professional (HCP) perspectives on barriers and facilitators in axSpA diagnosis. This study explored the experiences and perceptions of both groups regarding the factors affecting the timely diagnosis of axSpA.

Method
Semi-structured interviews with patients with axSpA and axSpA-interested HCPs from the United Kingdom (UK) were performed by telephone or Microsoft Teams and focussed on the individuals’ perspective of the diagnostic journey for axSpA. Interview transcripts were thematically analysed.

Results
Fourteen patients with axSpA (10 female, 4 male) and 14 UK based HCPs were recruited, the latter comprising of 5 physiotherapists, 4 General Practitioners, 3 rheumatologists, a nurse, and an occupational therapist. Barriers to diagnosis identified by patients and HCPs were: difficult to diagnose, a lack of awareness, unclear referral pathways, patient behaviour and patient/HCP communication. Patient-identified facilitators of diagnosis were patient advocacy, clear referral processes and pathways, increased awareness, and serendipity. HCPs identified promoting awareness as a facilitator of diagnosis, along with symptom recognition, improvements to healthcare practice and patient/HCP communications.

Conclusion
Poor communication and a lack of understanding of axSpA in the professional and public spheres undermine progress towards timely diagnosis of axSpA. Improving communication and awareness for patients and HCPs, along with systemic changes in healthcare (such as improved referral pathways) could reduce diagnostic delay.
Species-Dependent Impacts on the Nutritional Profile of Tomato (Solanum lycopersicum L.) and Rocket (Eruca sativa L.) Plants Following to Foliar Application of Yeast Suspensions
Authors: Tóbiás Andrea , Ladányi Márta , Koren Dániel , Csambalik László 
Published: March 2024

AbstractThe foliar application of yeast (Saccharomyces cerevisiae) suspensions is a widely used small-scale horticultural practice against stress impacts and to boost vegetative and nutritional characteristics. In this study, the impact of two strains of S. cerevisiae was investigated on tomato (Solanum lycopersicum L.) and rocket (Eruca sativa L.) plants in terms of vegetative growth and nutritional content, focusing on antioxidant properties (FRAP, DPPH, TPC, lycopene) and chlorophyll content. The treatments were applied in two dilutions (0.1 and 1% v/v) and two frequencies (once and three times). When the type strain solutions were applied, DPPH values of both tomato and rocket samples were elevated up to 7.18 and 17.98 i%, respectively, compared to control values of 6.26 and 14.11 i%, respectively. While the other investigated antioxidant traits (FRAP, TPC, lycopene) were identical or slightly lower, than the control values, total chlorophyll content was significantly increased for tomato, up to 61.18 g/100 g, from the control value of 53.46 g/100 g, and for rocket, reaching 43.14 g/100 g, from the control value of 39.13 g/100 g, after using instant yeast solutions. Among the combinations, the double-sprayed 1% suspension and the single-sprayed 0.1% suspension had the most favorable impact on the investigated nutritional traits. Species-level application technology details are still open for refinements.