bluuebunny/crossref_metadata_2025_split huggingface dataset:
Guided internet‐based acceptance and commitment therapy for provoked vestibulodynia: A randomized controlled trial
Authors: Buhrman Monica , Hällström Hanna , Fridén Annika , Kettis Moden Emma , Grahn Gunnar , Carlfjord Maja , Hjo Camille , Gasslander Nils , Bohm‐Starke Nina , McCracken Lance M. 
Published: March 2024

AbstractBackgroundProvoked vestibulodynia (PVD) causes suffering in many women's lives due to its impact on relationships, sexual functioning and functioning in other key domains.ObjectiveHere, we report a randomized controlled trial conducted to examine whether Acceptance and Commitment Therapy (ACT) with a focus on values‐based exposure, delivered online, benefits women with PVD.MethodsParticipants (n = 88) were randomized to either guided online ACT for 10 weeks or a wait‐list control group. Outcomes were assessed at baseline, post treatment and 1 year later. Analyses were based on intention to treat using linear mixed models.ResultsThere were significant group differences on the primary outcomes, Female Sexual Index and Female Sexual Distress Scale, in favour of online ACT with moderate effect sizes. Differences were also found on several secondary outcomes and therapeutic process measures, all in favour of ACT. No differences were found at post‐treatment for depression or anxiety. At the 1‐year follow‐up, results were maintained and a difference between baseline and follow‐up was also found for depression.Conclusion/SignificanceIn summary, a relatively brief, guided, online version of ACT appears to produce benefits for women with PVD and related impacts on daily functioning. 50% to 60% of the women who participated in the treatment reliably improved in sexual functioning and distress.
Modeling and performance analysis of a lithium‐ion battery pack with an electric vehicle power‐train for different drive cycles and highway conditions
Authors: Harikrishnan Mannilputhiyaveedu RadhakrishnaPillai , Kanakasabapathy Ponnusamy 
Published: March 2024

AbstractLithium‐ion cell chemistries are favored in the automotive sector, as they enable electric vehicles (EVs) to compete with traditional gasoline‐powered vehicles in terms of performance, range, and cost. The life and performance of these packs depend upon the Battery management system which monitors and controls the pack. The modeling, simulation, and analysis of a lithium‐ion battery pack that closely resembles an actual automobile battery are the focus of this paper. Real cells that are commercially available and specifically developed for automotive applications are modeled in the simulation environment. The cell characterization and formation of pack topology with heat exchange are addressed. A commercial electric car's power train model and EV dynamics are used in the simulation environment to test the modeled battery pack over various drive cycles. The performance analysis is upscaled by considering different aspects like resistive forces while driving, ambient temperature, initial conditions while the vehicle starts, etc. The battery manufacturer can verify the battery's performance under different load conditions, with a high degree of similarity to real‐world scenarios. The simulations are conducted on MATLAB/Simulink 2021b software.
Correlation‐based tests of predictability
Authors: Brown Pablo Pincheira , Hardy Nicolás 
Published: March 2024

AbstractIn this paper, we propose a correlation‐based test for the evaluation of two competing forecasts. Under the null hypothesis of equal correlations with the target variable, we derive the asymptotic distribution of our test using the Delta method. This null hypothesis is not necessarily equivalent to the null of equal Mean Squared Prediction Errors (MSPE). Specifically, it might be the case that the forecast displaying the lowest MSPE also exhibits the lowest correlation with the target variable: this is known as “The MSPE paradox.” In this sense, our approach should be seen as complementary to traditional tests of equality in MSPE. Monte Carlo simulations indicate that our test has good size and power. Finally, we illustrate the use of our test in an empirical exercise in which we compare two different inflation forecasts for a sample of OECD economies. We find more rejections of the null of equal correlations than rejections of the null of equality in MSPE.
Effects of dopamine and opioid receptor antagonism on the neural processing of social and nonsocial rewards
Authors: Massaccesi Claudia , Korb Sebastian , Götzendorfer Sebastian , Chiappini Emilio , Willeit Matthaeus , Lundström Johan N. , Windischberger Christian , Eisenegger Christoph , Silani Giorgia 
Published: March 2024

AbstractRewards are a broad category of stimuli inducing approach behavior to aid survival. Extensive evidence from animal research has shown that wanting (the motivation to pursue a reward) and liking (the pleasure associated with its consumption) are mostly regulated by dopaminergic and opioidergic activity in dedicated brain areas. However, less is known about the neuroanatomy of dopaminergic and opioidergic regulation of reward processing in humans, especially when considering different types of rewards (i.e., social and nonsocial). To fill this gap of knowledge, we combined dopaminergic and opioidergic antagonism (via amisulpride and naltrexone administration) with functional neuroimaging to investigate the neurochemical and neuroanatomical bases of wanting and liking of matched nonsocial (food) and social (interpersonal touch) rewards, using a randomized, between‐subject, placebo‐controlled, double‐blind design. While no drug effect was observed at the behavioral level, brain activity was modulated by the administered compounds. In particular, opioid antagonism, compared to placebo, reduced activity in the medial orbitofrontal cortex during consumption of the most valued social and nonsocial rewards. Dopamine antagonism, however, had no clear effects on brain activity in response to reward anticipation. These findings provide insights into the neurobiology of human reward processing and suggest a similar opioidergic regulation of the neural responses to social and nonsocial reward consumption.
Metabolomic landscape of overall and common cancers in the UK Biobank: A prospective cohort study
Authors: Hu Chanchan , Fan Yi , Lin Zhifeng , Xie Xiaoxu , Huang Shaodan , Hu Zhijian 
Published: March 2024

AbstractInformation about the NMR metabolomics landscape of overall, and common cancers is still limited. Based on a cohort of 83,290 participants from the UK Biobank, we used multivariate Cox regression to assess the associations between each of the 168 metabolites with the risks of overall cancer and 20 specific types of cancer. Then, we applied LASSO to identify important metabolites for overall cancer risk and obtained their associations using multivariate cox regression. We further conducted mediation analysis to evaluate the mediated role of metabolites in the effects of traditional factors on overall cancer risk. Finally, we included the 13 identified metabolites as predictors in prediction models, and compared the accuracies of our traditional models. We found that there were commonalities among the metabolic profiles of overall and specific types of cancer: the top 20 frequently identified metabolites for 20 specific types of cancer were all associated with overall cancer; most of the specific types of cancer had common identified metabolites. Meanwhile, the associations between the same metabolite with different types of cancer can vary based on the site of origin. We identified 13 metabolic biomarkers associated with overall cancer, and found that they mediated the effects of traditional factors. The accuracies of prediction models improved when we added 13 identified metabolites in models. This study is helpful to understand the metabolic mechanisms of overall and a wide range of cancers, and our results also indicate that NMR metabolites are potential biomarkers in cancer diagnosis and prevention.
Healthy dietary patterns and risk of prostate cancer in men at high genetic risk
Authors: Zhang Yiwen , Stopsack Konrad H. , Song Mingyang , Mucci Lorelei A. , Liu Binkai , Penney Kathryn L. , Tabung Fred K. , Giovannucci Edward , Plym Anna 
Published: March 2024

AbstractProstate cancer has high heritability. Healthy lifestyle has been associated with lower lethal prostate cancer risk among men at increased genetic susceptibility, but the role of healthy dietary patterns remains unknown. We prospectively followed 10,269 genotyped men in the Health Professionals Follow‐up Study (1993–2019). Genetic risk was quantified using an established polygenic risk score (PRS). Five dietary patterns were investigated: healthy eating index, Mediterranean, diabetes risk‐reducing, hyperinsulinemic and inflammatory diet. Overall and lethal prostate cancer rates (metastatic disease/prostate cancer‐specific death) were analyzed using multivariable Cox proportional hazards models. During 26 years of follow‐up, 2133 overall and 253 lethal prostate cancer events were documented. In the highest PRS quartile, higher adherence to a diabetes risk‐reducing diet was associated with lower rates of overall (top vs. bottom quintile HR [95% CI], 0.74 [0.58–0.94]) and lethal prostate cancer (0.43 [0.21–0.88]). A low insulinemic diet was associated with similar lower rates (overall, 0.76 [0.60–0.95]; lethal, 0.46 [0.23–0.94]). Other dietary patterns showed weaker, but similar associations. In the highest PRS quartile, men with healthy lifestyles based on body weight, physical activity, and low insulinemic diet had a substantially lower rate (0.26 [0.13–0.49]) of lethal prostate cancer compared with men with unhealthy lifestyles, translating to a lifetime risk of 3.4% (95% CI, 2.3%–5.0%) among those with healthy lifestyles and 9.5% (5.3%–16.7%) among those with unhealthy lifestyles. Our findings indicate that lifestyle modifications lowering insulin resistance and chronic hyperinsulinemia could be relevant in preventing aggressive prostate cancer among men genetically predisposed to prostate cancer.
Unraveling the cross‐talk between N6‐methyladenosine modification and non‐coding RNAs in breast cancer: Mechanisms and clinical implications
Authors: Liu Xuan , Xie Xuelong , Sui Chentao , Liu Xuexue , Song Miao , Luo Qing , Zhan Ping , Feng Jia , Liu Jinbo 
Published: March 2024

AbstractIn recent years, breast cancer (BC) has surpassed lung cancer as the most common malignant tumor worldwide and remains the leading cause of cancer death in women. The etiology of BC usually involves dysregulation of epigenetic mechanisms and aberrant expression of certain non‐coding RNAs (ncRNAs). N6‐methyladenosine (m6A), the most prevalent RNA modification in eukaryotes, widely exists in ncRNAs to affect its biosynthesis and function, and is an important regulator of tumor‐related signaling pathways. Interestingly, ncRNAs can also regulate or target m6A modification, playing a key role in cancer progression. However, the m6A‐ncRNAs regulatory network in BC has not been fully elucidated, especially the regulation of m6A modification by ncRNAs. Therefore, in this review, we comprehensively summarize the interaction mechanisms and biological significance of m6A modifications and ncRNAs in BC. Meanwhile, we also focused on the clinical application value of m6A modification in BC diagnosis and prognosis, intending to explore new biomarkers and potential therapeutic targets.
Prognostic nomogram for predicting the overall survival rate of patients with uterine clear‐cell carcinoma: Based on SEER database
Authors: Huang Ting , Lu Fan 
Published: March 2024

AbstractObjectiveTo evaluate the risk factors for uterine clear‐cell carcinoma (UCCC) and construct nomograms predicting 1‐, 3‐, and 5‐year overall survival rates of patients with UCCC.MethodsThe demographic and clinical information of 1674 patients diagnosed with UCCC between 2004 and 2015, including age, race, marital status, tumor size, American Joint Committee on Cancer (AJCC) stage, and details of surgery and radiotherapy/chemotherapy, was collected from the Surveillance, Epidemiology, and End Results (SEER) database. After excluding patients with unknown AJCC stage, race, marital status, or lymph node information, 1469 patients remained. Risk factors were determined using univariate and multivariate analyses, and nomograms were developed to predict 1‐, 3‐, and 5‐year overall survival of UCCC. Various indicators were used to evaluate the performance of the nomogram, such as the C‐index, net classification improvement (NRI) and decision curve analysis (DCA).ResultsAge, log odds of positive lymph nodes, AJCC stage, surgery status, and chemotherapy status were independent risk factors for UCCC. The C‐indexes of the training group and AJCC stage groups were 0.771 and 0.697, respectively. The results for the area under the receiver operating characteristics curve, NRI, and calibration curves indicated that the nomogram had good predictive ability. DCA revealed that the nomogram had greater clinical applicability than AJCC stage alone. Internal validation using the validation cohort also demonstrated that this nomogram had good predictive performance.ConclusionA new nomogram comprising a combination of demographic and clinical characteristics provided better survival predictions than the AJCC staging system alone, which will facilitate prognostic assessments and clinical decision‐making.
Maternal GBS vaccination for preventing group B streptococcus disease in newborns: A mini review of current evidence
Authors: Kokori Emmanuel , Olatunji Gbolahan , Komolafe Rosemary , Ogieuhi Ikponmwosa Jude , Oyebiyi Babajide , Ajayi Irene , Muogbo Ifeanyichukwu , Ukoaka Bonaventure , Samuel Owolabi , Aderinto Nicholas 
Published: March 2024

AbstractGroup B streptococcus (GBS) poses a significant threat to neonates, leading to morbidity and mortality. Intrapartum antibiotics, although effective, have limitations, prompting the exploration of maternal vaccination. This study reviews the current evidence for maternal GBS vaccination in the prevention of early‐onset GBS disease in newborns. A search on Google Scholar, PubMed, and Scopus identified studies assessing the impact of maternal GBS vaccination on early‐onset GBS disease. Inclusion criteria comprised English‐language clinical trials or observational studies. Data extraction included study details, immunogenicity profiles, effectiveness, safety outcomes, and relevant findings. Qualitative synthesis was employed for data analysis. Five studies meeting the inclusion criteria were reviewed. Maternal GBS vaccines demonstrated efficacy with sustained immunogenicity. Adverse events, although documented, were predominantly non‐severe. Variability in immune responses and maternal‐to‐infant antibody ratios show the need for tailored vaccination approaches. Long‐term follow up and surveillance are essential to assess persistence and identify unintended effects. Positive outcomes in vaccine efficacy support GBS vaccination integration into maternal health programs. Implementation challenges in diverse healthcare infrastructures require tailored approaches, especially in resource‐limited settings. Overcoming cultural barriers and ensuring healthcare provider awareness are crucial for successful vaccination.
Complete retroperitoneal cutaneous ureterostomy with robot‐assisted radical cystectomy
Authors: Tanaka Shiori , Kitano Goshi , Kato Manabu , Ogura Yuji , Kojima Takahiro 
Published: March 2024

IntroductionCutaneous ureterostomy is beneficial for older patients in a hypoalimentation state, providing less invasive options than intestinal tract reconstruction techniques. However, complications such as ileus and stoma site hernia still pose risks owing to the anatomical location of the ureter. We introduce a novel method, complete retroperitoneal cutaneous ureterostomy, performed simultaneously with robot‐assisted radical cystectomy.Case presentationOur technique involves extending the retroperitoneal space to minimize complications and achieve stent‐free outcomes. The median procedure time for complete retroperitoneal cutaneous ureterostomy was approximately 30 min. The stent‐free rates at 1 and 4 months postoperatively were 66.7% and 100%, respectively; no case of stent reinsertion after stent removal was reported.ConclusionOur approach is promising for avoiding postoperative intestinal tract complications.
Assessment of magnetic resonance imaging and histopathological changes in chordoid glioma: A retrospective analysis of 13 cases
Authors: Huang Cong , Deng Li‐hua , Wen Feng , He Peng , Zhou Xing‐shun , Yu Zhen‐ni , Zhao Zi‐lin , Luo Jun‐de 
Published: March 2024

AbstractChordoid glioma (CG) is a rare tumor, and its predominantly anterior location is in the third ventricle. However, the clinical characteristics of CG were not obvious, and there was less knowledge of CG‐related imaging. This study aimed at exploring the MRI imaging features of CG. We retrospectively analyzed the MRI data of 13 patients diagnosed with CG from January 2015 to May 2021. The pathological change of tumor tissue was observed using H&E staining and immunohistochemical. The MRI manifestations of CG often include phyllode masses in the anterior part of the third ventricle. T2WI is dominated by iso‐ and hypointensity, with internal patchy hyperintensity, marked enhancement, and peritumoral edema. The “eight‐character edema sign” runs along the optic beam and may be useful for distinguishing CG from other tumors. CG has unique MRI manifestations that can serve as a diagnostic basis. Our study may help to enhance the understanding of imaging about CG and improve the diagnosis of patients with CG.
Offline and online parental mentalizing in mothers with symptoms of postpartum depression: Examining the association between self‐reported parental reflective functioning and interactional mind‐mindedness
Authors: Wendelboe Katrine I. , Stuart Anne C. , Smith‐Nielsen Johanne , Linkhorst Thea B. , Væver Mette Skovgaard 
Published: March 2024

AbstractMentalizing is, to a certain extent, considered context specific. However, research on the association between parents’ abilities to reflect upon their infant's mental states outside social interaction (offline) versus during ongoing parent‐infant interaction (online) is currently limited. This study investigated the association between self‐reported offline and online mentalizing in a sample of primarily ethnically Danish mothers (N = 142), with symptoms of postpartum depression, and their 1–11‐month‐old infants. Offline mentalizing was assessed with the Parental Reflective Functioning Questionnaire—Infant Version (PRFQ‐I) and online mentalizing was assessed with interactional mind‐mindedness. Ordinal logistic regressions showed that a higher score on the PRFQ‐I prementalizing subscale was negatively related to number of overall mind‐related comments and appropriate mind‐related comments produced by mothers during interaction with their infant. Our results indicate partial overlaps between self‐reported parental reflective functioning and mind‐mindedness, that is, that particularly offline maladaptive mentalizing is associated with lower levels of mentalizing during interaction in mothers with symptoms of depression. Post‐hoc examination of the interaction effect of postpartum depression showed that this association was only evident in mothers with medium to high levels of depression. Findings and implications are discussed.
Real‐time breast lesion classification combining diffuse optical tomography frequency domain data and BI‐RADS assessment
Authors: Li Shuying , Zhang Menghao , Xue Minghao , Zhu Quing 
Published: March 2024

AbstractUltrasound (US)‐guided diffuse optical tomography (DOT) has demonstrated potential for breast cancer diagnosis, in which real‐time or near real‐time diagnosis with high accuracy is desired. However, DOT's relatively slow data processing and image reconstruction speeds have hindered real‐time diagnosis. Here, we propose a real‐time classification scheme that combines US breast imaging reporting and data system (BI‐RADS) readings and DOT frequency domain measurements. A convolutional neural network is trained to generate malignancy probability scores from DOT measurements. Subsequently, these scores are integrated with BI‐RADS assessments using a support vector machine classifier, which then provides the final diagnostic output. An area under the receiver operating characteristic curve of 0.978 is achieved in distinguishing between benign and malignant breast lesions in patient data without image reconstruction.
Improving the spatial resolution and signal‐to‐noise ratio of ultrasound switchable fluorescence imaging
Authors: Yu Shuai , Yuan Baohong 
Published: March 2024

AbstractUltrasound switchable fluorescence (USF) imaging, a hybrid imaging technology that combines the advantages of both fluorescence sensitivity and acoustic resolution in centimeter‐deep tissue, has great potential for biomedical different applications. A camera‐based USF imaging system reveals its capability of capturing both spatial and temporal dynamics of the USF signal in tissue. In this study, various algorithms were explored to enhance the spatial resolution and signal‐to‐noise ratio (SNR) of USF images, utilizing temporal and spatial information from a camera‐based time‐domain USF imaging system. The correlation method proved effective in boosting SNR, while the ascending‐slope‐weighted method enhanced spatial resolution. Additionally, the spatially back‐projection method significantly improved spatial resolution in silicone phantoms. The results underscore the advantages of incorporating temporal and spatial information from USF signals.
Effect of S doping on structural and photoelectrochemical properties of LaFeO3 nanocomposites
Authors: Li Shudan , Zhu Xinyue , Gao Kun 
Published: March 2024

AbstractS‐doped LaFeO3 nanocomposites were successfully synthesized for the first time using a hydrothermal method coupled with a low‐temperature solid phase method. Characterization results revealed that S atoms were successfully incorporated into LaFeO3 and existed predominantly in the form of S6+ within the LaFeO3 lattice. The sulfur doping enhanced the textural and photoelectrochemical characteristics of LaFeO3.