bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Ventricular Abnormalities in Children with Idiopathic Ventricular Extrasystoles
Authors: Kunigeliene Rita , Kinciniene Odeta , Marinskis Germanas , Usonis Vytautas 
Published: February 2025

Background and Objectives: Ventricular extrasystoles, which are the most common arrhythmias in healthy children and adolescents, could be a reliable factor for the prognosis of structural heart diseases. However, extrasystoles arising in hearts with primary myocardial diseases or channelopathies might cause life-threatening events or be associated with arrhythmia-induced cardiomyopathy. The relationship between ventricular extrasystoles and ventricular abnormalities in children remains controversial. The aim of this study was to evaluate prevalence of ventricular abnormalities in children with ventricular extrasystoles. Materials and Methods: This was a retrospective cohort study of pediatric outpatients in Vilnius University Hospital Santaros Clinics because of ventricular extrasystoles. The inclusion criteria were 3–18-year-old children with more than 5% extrasystoles per 24 h. The exclusion criteria were previous diagnoses of congenital heart defects, cardiomyopathies, and channelopathies. We reviewed the results of electrocardiography, cardiac imaging, and cardiogenetic tests. Results: In total, 131 patients (55.7% males) were included from a database of 915 patients, of whom 79.4% ventricular extrasystoles were found incidentally. Ventricular extrasystoles were monomorphic—95.4%, multiform—4.6%, and consecutive—29.8%. Cardiac magnetic resonance imaging was performed on 22.9% of patients with one-third of the pathological findings (ventricular dysfunction and myocardial fibrosis). Ventricular dysfunction was associated with a higher frequency of ventricular extrasystoles, with a median highest frequency of 26.5% per 24 h. Cardiogenetic testing was performed on only five (3.8%) patients, and RyR2 mutation was detected in one. Conclusions: According to our results, ventricular dysfunction was strongly associated with a higher burden of ventricular extrasystoles.
Tip-enhanced photoluminescence imaging of porphyrin tapes: exploring the nonlocality of molecular orbitals
Authors: Tomoshige Yoshitsugu , Tamura Mamoru , Ishihara Hajime 
Published: February 2025

Abstract
We have developed a theoretical framework for evaluating tip-enhanced photoluminescence (TEPL) of single molecules based on the nonlocal response theory. This framework self-consistently solves molecular polarization and electric field using a Green’s function accounting for arbitrary nanostructure geometries. Focusing on porphyrin tape molecules (two, four, and six units), our study reveals two-lobe TEPL images, where lobe separation increases with molecular size, deviating from point dipole approximations. Furthermore, TEPL images of optically forbidden transitions reflect the spatial structure of wavefunction and polarization. These calculations, clarifying mechanisms underlying experimental observations, advance understanding of nanoscale light–matter interactions and guide molecule-based photonic device design.
Identifikasi Kelainan Gen Protein Pita 3 pada Membran Sel Darah Merah Penderita Talasemia Î²
Authors: Dewajanti Anna Maria 
Published: February 2025

Abstract : Thalassemia is a genetic disorder inherited as autosomal recessive. There is an imbalance Between the number of goblin chains Î± and b globin chains, so that there is an unpaired globin chains. Precipitation of unpaired globin chains in the membrane can lead to autooxidation the membrane so that it Can cause the cell membranes become rigid. Stability of red blood cell is very influenced by protein sitoskeleton function. Others the stability of red blood cells is also greatly influence by the band 3 protein, an integral transmembrane protein of red blood cells. Band 3 protein abnormalities may influence its function both as an ion exchange membraneÂ and in maintaining the stability of red blood cells. Abnormal band 3 protein found in ovalositosis, a blood di sorder caused by the loss of nine amino acids of protein band 3 due to a deletion of codons 400-408 in exon 11 band 3 protein gene. The loss of nine amino acids in the protein band 3 ovalositosis causes red blood cell membranes become rigid, thus reducing the membrane deformability. The existence of rigidity accompanied by a decreased ability of red blood cell membrane deformability thalassemia-like red blood cell membrane ovalositosis, raises the idea that the destruction of red blood cell membrane protein also thalassemia is caused by abnormalities band 3 protein-coding genes. This study aims to identify any abnormalities of band 3 protein gene in patients with thalassemia. Genomic DNA obtained from blood of healthy individuals and patients with thalassemia. Genes will be examined later propagated by PCR and visualization techniques using 2% agarose gel electrophoresis. PCR results of band 3 protein gene in healthy individuals (normal) size of 175 Â± 25 bp, whereas in patients with thallasemia found two PCR product size 175 bp and 110 Â± 25 Â± 15 bp. Presence of PCR product size 110 Â± 15 bp showed a proteinÂ band 3 gene defects in patients with thalassemia in the form of gene deletion by 65 Â± 10 bp. Genetic disorder of protein band 3 in thalassemia is not the same as genetic abnormalities in ovalositosis.Key words : thalassemia, protein band 3 gene, genetic disorders.
Pengaruh Kalsium dalam Makanan Terhadap Penurunan Tekanan Darah
Authors: Winaktu Gracia J. 
Published: February 2025

Abstrackblood pressure is determined by cardiac output (cardiac output) and peripheral resistance. The relationship between inputs of calcium (Ca) with decreased blood pressure of essential hypertensive patientsâ€™ was first proposed b Â addison in 1924. Ca is a mineral that is essential for the human body. Calcium helps in activating enzymes that stimulate many essential chemical reaction in the body also plays a role in blood coagulation. Ca can only be absorbed by the intestine about 35%, due to relatively low degree of solubility. Approximately 90% of the input Ca in the diet excreted in the feces each day. Parathyroid Â hormone is released to maintain the concentration of Ca ions, will increase the influx of extracellular to intracelluler Ca ions, so that the intracellular Ca ion concentration is very high. The inputs of Ca hypertensive patients are lower than normal people. This means that the lack of input of Ca in the diet will lead to increased blood pressure.Key words : Calcium, hypertensive essential, parathyroid hormone.
Bilirubinometri Transkutaneus
Authors: Ruslie Riska Habriel , . Darmadi 
Published: February 2025

abstrakjaundice atau hiperbilirubinemia sering terjadi pada neonatus. walaupun kebanyakan Â kasus tidak berbahaya, hiperbilirubinemia berat dapat menyebabkan kernikterus, yang dapat di cegah jika hiperbilirubinemia diindefikasikan sejak dini dan di tatalaksanakan dengan tepat. Disusun lah artikel ini yang membahas mengenai jaundice pada neonatus dan penggunaan Â bilirubinometri transkutaneus untuk deteksi neonatus yang berisiko hiperbilirubinemia berat. pemeriksa bilirubin transkutaneus (TcB) adalah pilihan untuk skrining neonatus jika ada risiko secara kelinis terjadi hiperbilirubinemia.kata kunci: bilirubinometri transkutaneus, neonatus, skrining
Nilai Diagnosis N-Terminal Prohormone Brain Natriuretic Peptide untuk Mendeteksi Gagal Jantung Kronik Diastolik pada Pasien Hemodialistis Rutin di Unit Hemodialistis RSUPN Dr. Cipto Mangunkusumo Jakarta
Authors: Silalahi Todung , Panggabean Marulam M. , Alwi Idrus , I Suzanna , . Dharmeizar 
Published: February 2025

AbstractÂ Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Aims: to compare Ntpro-BNP levels in chronic kidney failure undergoing routine hemodialysis without diastolik heart failure,with chornic kidney failure patients undergoing routine hemodialysis with chronic diastolik heart failureÂ Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Methods and results: 60 chronic kindey disease in Cipto Mangunkusumo Hospital Hemodialysis unit were undergoing routine hemodialysis between june 2007 to October 2007 were chosen for the research. Their left ventricular functions, both sys tolic dan diastolik, were measured using echocardiography. Their mean NT pro-BNP values were also recorded. Mean of NT pro â€“BNP in normal LV fucition without diastolik dysfuncition in 41 pepople is 11.600,2 (sta ndard deviation 10.356,1),with minimum value of 61o,8 pg/ml and maximal vaule of 35,000 pg/ml, NT pro â€“BNP vaue of19.170 pg/dl as diagnostic test for diastolik heart failure thus shows that it haws 84% sensitivity and 80% specificity value.Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Conclusion: NT pro-BNP can be used to datect chronic diastolikÂ heart fa in patient undergoing routine hemodialysis keyÂ Â words: Echocardiography, NT pro-BNP, left ventricular funcition, chronic kidney failure, chronicÂ diastolik heart failureÂ Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â
Candidíase Vulvovaginal Recorrente
Authors: BARROS DE MACEDO RYAN RAFAEL , ROQUE DA SILVA CATARINE , DANTAS DA COSTA ISABEL BEATRIZ , SALES DE BARROS LUANA , VILA NOVA DOS SANTOS LETICIA FERNANDA , RÊGO DE MORAES MARIANA , SOUZA MARQUES VERÔNICA GABRIELA , TORRES MARCONDES MARCOS , SILVA SANTIAGO VÍVIAN , YUJRA QUELALI SONIA LORENA , FERREIRA DOS SANTOS JÚLIA , DE OLIVEIRA MOREIRA GABRIELLE 
Published: February 2025

RESUMO
A candidíase vulvovaginal recorrente (CVVR) é uma condição clínica complexa, caracterizada por múltiplos episódios sintomáticos anuais, com impacto significativo na qualidade de vida das pacientes. Este artigo analisa as estratégias terapêuticas e desafios no manejo da CVVR, destacando a resistência fúngica crescente, a diversidade de espécies de Candida e as limitações dos regimes convencionais baseados em azóis. Diretrizes internacionais recomendam terapia de indução e manutenção com fluconazol, porém até 50% das pacientes apresentam recorrência após a suspensão do tratamento, especialmente em casos envolvendo espécies não albicans (NAC) ou cepas resistentes. Alternativas como ácido bórico, nistatina e anfotericina B demonstraram eficácia em cenários específicos, embora com restrições de segurança e acesso. Inovações farmacológicas, como o oteseconazol e o ibrexafungerp, emergem como opções promissoras, com eficácia comprovada em ensaios clínicos contra cepas resistentes e NAC, enquanto a vacina NDV-3A sinaliza avanços na imunomodulação. O manejo em populações especiais, como diabéticas e mulheres vivendo com HIV, exige abordagens individualizadas, incluindo controle glicêmico rigoroso e evitando interações medicamentosas. A formação de biofilmes e a escassez de antifúngicos eficazes contra NAC destacam a necessidade de pesquisas futuras em terapias combinadas e disruptores de resistência. Conclui-se que a personalização do tratamento, aliada a investimentos em novas moléculas e estratégias preventivas, é essencial para reduzir a recorrência e melhorar os desfechos clínicos.
VENTRICULOSTOMIA ENDOSCÓPICA DO TERCEIRO VENTRÍCULO NO MANEJO DA HIDROCEFALIA PEDIÁTRICA
Authors: Guimarães ´Pedro Figueiredo , Andrade Bianca de Figueiredo Moreira , Mansur Guilherme , Carvalho Ramos Dutra Sâmela , Sousa Lucas Silva , Bastos Francisco Antônio Dias de Azeredo , Bastos Fernando Dias de Azeredo , Lopes Dionísio de Figueiredo 
Published: February 2025

O objetivo do artigo é avaliar os resultados clínicos e prognósticos da VETV no manejo da hidrocefalia pediátrica, comparando sua eficácia e segurança com a derivação ventriculoperitoneal (DVP). O estudo também visa identificar os principais fatores prognósticos associados ao sucesso ou falha do procedimento e discutir o impacto da VETV na qualidade de vida dos pacientes, além de destacar avanços tecnológicos recentes que podem influenciar os resultados cirúrgicos. Foi realizada uma revisão de literatura abrangente utilizando as bases de dados PubMed, LILACS e Scopus, relacionados a “Endoscopic Third Ventriculostomy”, “Hidrocefalia”, “Qualidade de Vida” e “Complicações Cirúrgicas”. Foram selecionados 10 artigos relevantes que abordam a eficácia, segurança, complicações e fatores prognósticos da VETV . A VETV mostrou-se uma alternativa eficaz à DVP, especialmente em pacientes com hidrocefalia obstrutiva. O sucesso do procedimento foi maior em crianças acima de um ano e naquelas com estenose do aqueduto de Sylvius. Fatores como idade inferior a um ano, hidrocefalia pós-hemorrágica e presença de septações ventriculares foram associados a maior risco de insuficiência precoce. As principais complicações relacionadas foram recidiva de hidrocefalia, infecção e fechamento prematuro do estoma. A VETV é uma técnica segura e eficaz no manejo da hidrocefalia pediátrica, particularmente em crianças com hidrocefalia obstrutiva e idade superior a um ano. Apesar de sua eficácia ser influenciada por múltiplos fatores prognósticos, o procedimento apresenta vantagens significativas em relação ao DVP em termos de qualidade de vida e redução de complicações a longo prazo. Estudos futuros, especialmente de longo prazo, são necessários para definir critérios mais precisos de indicação e melhorar os resultados clínicos.
PENGARUH METODE LATIHAN EL RONDO DAN CIRCLE PASSING DRILL TERHADAP KETEPATAN PASSING DALAM PERMAINAN SEPAKBOLA SSB HARIMAU BEKONANG TAHUN 2024
Authors: Pipit Fitria Yulianto  , Dwi Gunadi  , Muh. Ikhwan Iskandar  , Ronny Suryo Narbito  , Eriek Satya Haprabu  , Rayudya Cella Aprilianto  
Published: February 2025

Tujuan penelitian untuk mengetahui perbedaan pengaruh metode latihan el rondo dan circle passing drill terhadap ketepatan passing dalam permainan sepakbola pada atlet putra usia 15-17 Tahun SSB Harimau Bekonang Sukoharjo, dan jika ada perbedaan maka untuk mengetahui mana yang lebih baik antara metode latihan el rondo dan circle passing drill terhadap ketepatan passing dalam permainan sepakbola pada atlet putra usia 15-17 Tahun SSB Harimau Bekonang Sukoharjo. Sampel penelitian adalah Pada Atlet SSB Harimau Bekonang Sukoharjo dengan jumlah 30 siswa. Pengambilan sampel menggunakan teknik porpusive sampling. Variabel penelitian ini yaitu hasil ketepatan passing dengan latihan el rondo dan circle passing drill sebagai variabel bebas serta hasil ketepatan passing variabel terikat. Rancangan penelitian menggunakan pretest-posttest design. Tes untuk mengetahui ketepatan passing menggunakan tes ketepatan passing menggunakan petunjuk pelaksanaan tes dari Nur Hasan (2001: 157). Metode analisis data penelitian menggunakan rumus t-test yang diperhitungkan menggunakan rumus pendek. Hasil analisis data maka simpulan diperoleh: (1) Ada perbedaan pengaruh yang signifikan antara latihan el rondo dan circle passing drill terhadap ketepatan passing dalam permainan sepakbola pada atlet putra usia 15-17 Tahun SSB Harimau Bekonang Sukoharjo Tahun 2024. Hal ini dibuktikan dari hasil penghitungan tes akhir masing-masing kelompok yaitu thitung = 3.036 lebih kecil dari pada ttabel = 2,145 dengan taraf signifikasi 5%. (2) Latihan el rondo lebih baik pengaruhnya dari pada metode circle passing drill terhadap ketepatan passing dalam permainan sepakbola pada atlet putra usia 15-17 Tahun SSB Harimau Bekonang Sukoharjo Tahun 2024. Berdasarkan persentase peningkatan ketepatan passing dalam permainan sepak bola menunjukkan bahwa kelompok 1 (kelompok yang mendapat perlakuan dengan latihan el rondo) adalah 95.745% > kelompok 2 (kelompok yang mendapat latihan circle passing drill) adalah 58.929%.
Kata Kunci : El Rondo, Circle Passing Drill, Ketepatan Passing
Initial growth response of twelve
Saccharum
Complex genotypes to inoculation using
Nitrospirillum viridazoti
Authors: Silva Alex Paulo Lemos da , Silva Luíz Felipe Coutinho da , Alves Bruno José Rodrigues , Reis Veronica Massena 
Published: February 2025

ABSTRACT
Sugar and alcohol production in Brazil comes from planting hybrids from the crossing of species belonging to the Saccharum Complex. However, little is known about the growth response of these genera to inoculation using a diazotrophic bacteria Nitrospirillum viridazoti strain BR11145, currently recommended in Brazil as an inoculant for sugarcane growth promotion. This study aimed to evaluate the initial growth of 12 sugarcane genotypes inoculated or not with the strain BR11145. After 109 days, plant growth, biomass and macronutrient accumulation were evaluated. Fresh and dry mass at the end of the trial showed a positive response to inoculation for the genotypes US72-1319, CPDAU 849678, and NG77-122 of S. spontaneum and for Fiji 10 of Miscanthus. A negative response was observed for Q45416 of Saccharum sp. The growth of S. spontaneum US72-1319 is significantly improved by the inoculation with BR11145, which leads to a high accumulation of nutrients, especially N, standing out among the genotypes tested.
Automatic measurement of surface runoff at the plot scale
Authors: Rauber Lucas Raimundo , Reinert Dalvan José , Gubiani Paulo Ivonir , Nunes Kelvin Salbego , Mallman Micael Stolben 
Published: February 2025

ABSTRACT

Although the hydrological importance of water infiltration into the soil and surface runoff is well known, manual measurement of these processes, especially at the plot and hillslope scales, is laborious and requires a trained team. This study aimed to develop prototypes with the tipping bucket principle for the automatic monitoring of surface runoff at a plot scale (14.5 × 3 m). In total, 18 prototypes were built and installed in an experiment with different soil covers. Aspects of the construction, calibration, operation and maintenance of the prototypes were reported in this study. Prototypes showed a satisfactory ability to monitor surface runoff with flow rates up to ~80 L min
-1
. The devices have an adjustable resolution of up to 5 L pulse
-1
, and they are inexpensive, easy to construct and simple to maintain. Although designed for a specific plot size (43.5 m
2
), the equipment can be adapted to smaller or larger plots by adjusting the volume of the tipping chambers. The proposed systems allow greater practicality in conducting experiments to monitor water loss through surface runoff at the plot scale and provide more detailed recordings of information.
Drugie życie psychodelików
Authors: Gołembiowska Krystyna , Kamińska Katarzyna 
Published: February 2025

Psychedelics known for mankind from millennia are class of compounds that alter consciousness, affect perception and produce hallucinations. Classic psychedelics such as psilocybin, mescaline, dimethyltryptamine (DMT) and lysergic acid diethylamide (LSD) have pharmacodynamic serotonergic effects. They are known to exert profound effects on neuroplasticity i.e. alteration of neuronal structure and function. The psychoplastogenic properties led to their potential in treatment of depression, neurodegenerative disorders such as Alzheimer’s Disease, recovery after stroke and in schizophrenia. The role of microdosing regarded as 10% of the dose that elicits psychedelic effects needs extensive investigation.
A Candidate High-velocity Exoplanet System in the Galactic Bulge
Authors: Terry Sean K. , Beaulieu Jean-Philippe , Bennett David P. , Bhattacharya Aparna , Hulberg Jon , Huston Macy J. , Koshimoto Naoki , Blackman Joshua W. , Bond Ian A. , Cole Andrew A. , Lu Jessica R. , Ranc Clément , Rektsini Natalia E. , Vandorou Aikaterini 
Published: February 2025

Abstract
We present an analysis of adaptive optics images from the Keck I telescope of the microlensing event MOA-2011-BLG-262. The original discovery paper by Bennett et al. reports two possibilities for the lens system: a nearby gas giant lens with an exomoon companion or a very low-mass star with a planetary companion in the Galactic bulge. The ∼10 yr baseline between the microlensing event and the Keck follow-up observations allows us to detect the faint candidate lens host (star) at K = 22.3 mag and confirm the distant lens system interpretation. The combination of the host star brightness and light curve parameters yields host star and planet masses of M
host = 0.19 ± 0.03 M
⊙ and m
p = 28.92 ± 4.75 M
⊕ at a distance of D
L = 7.49 ± 0.91 kpc. We perform a multiepoch cross reference to Gaia Data Release 3 and measure a transverse velocity for the candidate lens system of v
L = 541.31 ± 65.75 km s−1. We conclude this event consists of the highest-velocity exoplanet system detected to date, and also the lowest-mass microlensing host star with a confirmed mass measurement. The high-velocity nature of the lens system can be definitively confirmed with an additional epoch of high-resolution imaging at any time now. The methods outlined in this work demonstrate that the Roman Galactic Exoplanet Survey will be able to securely measure low-mass host stars in the bulge.
Innovating Nursing Education Through Partnership With Individuals With Intellectual and Developmental Disabilities
Authors: Fisher Mark J. , Graff J. Carolyn , Hill Cindy , LaMothe Julie , Nelson Serge' R. , Kent Kathleen A. , Betz Cecily L. 
Published: February 2025

Background
Health disparities of individuals with intellectual and developmental disabilities (IDD) have been a longstanding public health concern. Unlike the engagement of service sectors and governmental entities in advocating for human rights and health equity, the nursing profession remains absent from these discussions. Transformational changes are needed to promote systemic changes that will improve health outcomes of individuals with IDD.

Method
Strategic planning is needed to effect transformational changes in nursing education. Innovation in nursing education involves an informed understanding of health care barriers that individuals with IDD experience and the necessary processes to effectively engage in partnerships with this population.

Results
An approach for change in nursing education is proposed based on IDD concepts in federal legislation and initiatives, social policies, and the self-advocacy movement, and its application in nursing education is described.

Conclusion

Integrating IDD concepts into nursing curricula can improve health care equity and health outcomes of individuals with IDD.

[
J Nurs Educ
. 2025;64(2):75–80.]
Une industrie discrète cachée dans un paysage banal ? Réflexion à partir de la périphérie d’une petite ville lorraine, Pont-à-Mousson
Authors: Calenge Pierric 
Published: February 2025

Dans le cadre d’un paysage périphérique d’une petite ville, l’industrie peut par sa discrétion être ignorée. En effet, les espaces industriels discrets situés en périphérie des villes petites et moyennes passent facilement inaperçus : ne relevant pas toujours d’une spécialisation locale forte ou de chaînes de productions mondialisées stratégiques, ces espaces industriels se confondent par leur aspect avec les activités logistiques, artisanales et commerciales dans un paysage banal de hangars fonctionnalistes. En périphérie de l’agglomération de Pont-à-Mousson (Meurthe-et-Moselle), une zone d’activité sera l’objet d’une analyse paysagère portant sur le niveau d’insertion spatiale de l’industrie.