bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling Bitcoin networks in terms of anonymity and privacy in the metaverse application within Industry 5.0: Comprehensive taxonomy, unsolved issues and suggested solution
Authors: Mohammad Zainab Khalid , Bin Yousif Salman , Bin Yousif Yunus 
Published: April 2024

AbstractThe metaverse, a virtual multiuser environment, has garnered global attention for its potential to offer deeply immersive and participatory experiences. As this technology matures, it is evolving in tandem with emerging innovations such as Web 3.0, Blockchain, nonfungible tokens, and cryptocurrencies like Bitcoin, which play pivotal roles in the metaverse economy. Robust Bitcoin networks must be modelled for the metaverse environment in Industry 5.0 platforms to ensure the metaverse’s sustained growth and relevance. Industry 5.0 is poised to experience significant economic expansion, driven in large part by the transformative influence of metaverse technology. Researchers have actively explored diverse strategies and approaches to address the unique challenges and opportunities presented by current Bitcoin networks, highlighting the limitless potential for enhancing anonymity and privacy while navigating this exciting digital frontier. By addressing the diverse anonymity and privacy evaluation attributes, the lack of clarity regarding the prioritisation of these attributes and the variability in data, this modelling approach can be categorised as a form of multiple attribute decision-making (MADM). This review seeks to achieve three main objectives: firstly, to identify research gaps, obstacles, and problems within scholarly literature, which is crucial for assessing and modelling Bitcoin networks to succour the metaverse environment of Industry 5.0; secondly, to pinpoint theoretical gaps, proposed solutions, and benchmarking of Bitcoin networks; and thirdly, to offer an overview of the existing validation and evaluation methods employed in the literature. This review introduced a unique taxonomy by intersecting “Bitcoin networks based on blockchain aspects” with “anonymity and privacy development attributes aspect.” It emphasised the study’s significance and innovation. The results illustrate that employing MADM techniques is highly suitable for modelling Bitcoin networks to support the metaverse within the context of Industry 5.0. This thorough review is an invaluable resource for academics and decision-makers, offering perspectives regarding the improvements, applications, and potential directions for evaluating Bitcoin networks to bolster the metaverse environment of Industry 5.0.
The crystal structure of (Z)-4-ethyl-2-((4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3,5-dimethyl-2H-pyrrol-1-ium 2,2'-spirobi[naphtho[1,8-de][1,3,2]dioxaborinin]-2-uide, C37H37BN2O4
Authors: Alsuhaibani Amnah Mohammed , Asiri Yazeed M. , Refat Moamen S. , Usman Rabia , Khan Arshad 
Published: April 2024

Abstract
C37H37BN2O4, monoclinic, I2/a (no. 15), a = 13.8030(3) Å, b = 17.6109(2) Å, c = 14.1059(3) Å, β = 117.524(3)°, V = 3040.83(11) Å3, Z = 4, Rgt
(F) = 0.0340, wRref
(F
2) = 0.0867, T = 150 K.
Crystal structure of bis(methylammonium) hexadecaselenidopalladate(II), (CH3NH3)2PdSe16
Authors: Kim Kang-Woo , Noh Jong-Min 
Published: April 2024

Abstract
(CH3NH3)2PdSe16, tetragonal,

P

4
‾

b
2

$P\overline{4}b\mathrm{2}$

(no. 117), a = 12.7821(4) Å, c = 7.1123(2) Å, V = 1162.02(8) Å3, Z = 2, R
gt(F) = 0.0306, wR
ref(F
2) = 0.0841, T = 223 K.
The crystal structure of 1-(4-carboxybutyl)-3-methyl-1H-imidazol-3-ium hexafluoridophosphate, C9H15F6N2O2P
Authors: Mao Zhiwei , Zhang Kehua , Zhou Lian , Zou Wensheng 
Published: April 2024

Abstract
C9H15F6N2O2P, triclinic, P1̄ (no. 2), a = 8.678(8) Å, b = 9.085(9) Å, c = 10.279(8) Å, α = 84.23(2)∘, β = 79.02(2)∘, γ = 62.103(14)∘, V = 62.10(1) Å3, Z = 2, Rgt
(F) = 0.0730, wRref
(F
2) = 0.1663, T = 296 K.
Magnetized water-based hybrid nanofluid flow over an exponentially stretching sheet with thermal convective and mass flux conditions: HAM solution
Authors: Lone Showkat Ahmad , Raizah Zehba , Saeed Anwar , Bognár Gabriella 
Published: April 2024

Abstract
The boundary-layer flow on a shrinking/contracting sheet has abundant industrial applications, which include continuous glass casting, metal or polymer extrusions, and wire drawing. In this regard, the present analysis focuses the hybrid nanofluid flow on an exponentially extending sheet. The water-based hybrid nanofluid flow contains CoFe2O4 and TiO2 nanoparticles. Heat transfer rate analysis involves the utilization of the Cattaneo–Christov heat flux model. Moreover, the Brownian motion and thermophoresis effects are used in this novel work. The mathematical model is presented in the form of system of partial differential equations, which is then transformed into system of ordinary differential equations (ODEs) using the similarity variables. The system of ODEs is evaluated by homotopy analysis method. The variation in the flow profiles has been investigated using figures and tables. The conclusions demonstrate that the effect of magnetic parameter is 52% better for hybrid nanofluid flow than for the pure water. Conversely, the increasing magnetic parameter diminishes the thermal transfer rates for water, TiO2–H2O, CoFe2O4–H2O, and TiO2–CoFe2O4/H2O. The increasing thermophoresis parameter upsurges the thermal flow rate of nanofluids and hybrid nanofluid, while the increasing Brownian motion parameter lessens the thermal transfer rates of nanofluids and hybrid nanofluid. The increasing effect of thermophoresis parameter is 39% better for hybrid nanofluid than for the base fluid. However, the declining impression of Brownian motion factor is 48% greater for hybrid nanofluid related to pure water.
How do Financial Development and Stability Shape Human Development?
Authors: Awdeh Ali , Assaf Rima , Ghosn Fadi 
Published: April 2024

Abstract
The crucial role of financial systems in sustainable development has become the center of global and national interest and development strategies, and more developed and stable financial systems are the cornerstone for development finance and achieving the sustainable development goals. This research aims to examine the impact of financial development and stability on human development firstly in a sample of 185 countries worldwide, and secondly in a sample of 21 MENA countries, over the period 1990–2019. This study adopts the Panel Data Econometrics (Fixed Effects and Random Effects Methods) and proxy for human development by exploiting the UNDP’s Human Development Index and its three subindices (Education, Income, and Life expectancy), while it adopts broad money, credit to the domestic private sector, and banking sector deposits (all as a percentage of GDP) to proxy for financial development. Moreover, it represents financial stability by the banking sector Z-score and a dummy variable representing crises. The empirical results reveal the prevailing role of development and stability in the financial systems on human development and its three subcomponents, regardless of the country’s economic development level.
‘Reflexemes’ – a first cross-linguistic insight into how and why reflexive constructions encode emotions
Authors: Stephenson Alex , Ponsonnet Maïa , Allassonnière-Tang Marc 
Published: April 2024

Abstract
This article presents the first study on reflexive expressions having lexicalized an emotional meaning, as in the English example enjoy oneself. Such lexicalized forms, which we call ‘reflexemes’, occur in a number of genetically unrelated languages worldwide. Here we interrogate the cross-linguistic distribution and semantics of reflexemes, based on a sample of 58 languages from 6 genetic groups throughout Europe, Australia, and Asia. Reflexemes exhibit uneven distribution in this sample. Despite the presence of reflexemes across all three continents, European languages generally display much larger inventories. Based on our language sample’s contrasts, we hypothesize that these disparities could be driven by: the form of reflexive markers; their semantic range, including colexifications with anticausative constructions; and their longevity, with ancient, cognate European markers fostering accumulation of reflexemes via inheritance and borrowing. As for semantics, reflexemes target comparable emotions across languages. Specifically, categories labelled ‘Good feelings’, ‘Anger’, ‘Worry’, ‘Bad feelings’ and ‘Fear’ are consistently most prevalent. These tendencies apply across our sample, with no sign of family- or continent-specific semantic tendency. The observed semantic distribution may reflect universal lexicalization tendencies not specific to reflexemes, perhaps combined with an emphasis on self-evaluation and other social emotions imparted by reflexive semantics.
Diseño de panelería prefabricada en bambú para paredes en Costa Rica: caracterización mecánica preliminar
Authors: Sevilla Flores Kendy , Paniagua Hernández Viviana 
Published: April 2024

El objetivo de esta investigación fue diseñar un sistema de panelería prefabricada en bambú para paredes, partiendo de los beneficios medioambientales y socioeconómicos que se obtienen con el uso de este material. Para la validación del diseño se analizaron diversos aspectos constructivos, estructurales y socioeconómicos asociados. La metodología elegida consistió en generar matrices comparativas con indicadores, definiendo criterios para evaluar las posibilidades y parámetros de diseño y funcionamiento, valorando las implicaciones de la modulación, las articulaciones, los cerramientos y buscando optimizar la competitividad de la propuesta. Como resultados obtenidos, el sistema de paneles desarrollado es liviano, desarmable, flexible, permite diversas posibilidades de uso, es abierto a la combinación de cerramientos fijos y móviles. El agrupamiento de paneles a partir de sencillas adaptaciones en sus extremos posibilita distintas configuraciones para generar infraestructura, espacios educativos y de vivienda. Con la caracterización mecánica preliminar, realizada a partir de prototipos a escala construidos con la especie Plyllostachys aurea, se obtuvo resultados positivos que permiten confirmar la competitividad estructural y buen rendimiento del sistema. Se concluye que este trabajo no solo documenta los beneficios asociados a la toma de decisiones en diseño y a las especificaciones para la construcción, sino que se muestra la necesidad de continuar la investigación y desarrollo (I+D) del sistema prefabricado de paneles en bambú.
Bojaźń szacunkowa oraz symulacja całkowita zgody małżeńskiej w wyroku Roty Rzymskiej c. Salvatori z 26 października 2012
Authors: Góralski Wojciech 
Published: April 2024

Autor prezentuje i komentuje wyrok Trybunału Roty Rzymskiej z 26 października 2012 r., wydany w trzeciej instancji w sprawie o nieważność małżeństwa wniesionej z tytułu przymusu i bojaźni u pozwanej oraz symulacji zgody małżeńskiej u tejże kobiety (w pierwszej instancji zapadł wyrok pozytywny z tytułu przymusu i bojaźni, w drugiej natomiast zapadł wyrok negatywny). W Trybunale Roty Rzymskiej zapadł wyrok pozytywny (constare de nullitate) jedynie z tytułu przymusu i bojaźni. W dowodzeniu nieważności małżeństwa turnus rotalny wziął pod uwagę zarówno awersję pozwanej do powoda, jak i środki przymusu zastosowane wobec pozwanej przez jej rodziców.
Problem multicentryczności systemu prawa kanonicznego
Authors: Michowicz Przemyslaw 
Published: April 2024

Tematyka podjętego w pracy zagadnienia koncentruje się wokół problematyki zjawiska multicentryczności systemu prawa, także i systemu prawa kanonicznego. Punktem wyjścia dla identyfikacji kwestii jest precyzyjne określenie źródeł prawa kanoniczego oraz charakteru norm z nich wyprowadzonych przez właściwego ustawodawcę kościelnego. Czyni się to w kontekście dociekań, przedmiotem których jest rzekoma zmiana klasycznej struktury systemu prawa w porządek o charakterze cyrkularnym, który miałby być naturalnym następstwem kreowania norm prawnych w warunkach multicentryczności źródeł systemu prawa kanoniczego.
RapidAIM 2.0: a high-throughput assay to study functional response of human gut microbiome to xenobiotics
Authors: Li Leyuan , Mayne Janice , Beltran Adrian , Zhang Xu , Ning Zhibin , Figeys Daniel 
Published: April 2024

Aim: Our gut microbiome has its own functionalities which can be modulated by various xenobiotic and biotic components. The development and application of a high-throughput functional screening approach of individual gut microbiomes accelerates drug discovery and our understanding of microbiome-drug interactions. We previously developed the rapid assay of individual microbiome (RapidAIM), which combined an optimized culturing model with metaproteomics to study gut microbiome responses to xenobiotics. In this study, we aim to incorporate automation and multiplexing techniques into RapidAIM to develop a high-throughput protocol.
Methods: To develop a 2.0 version of RapidAIM, we automated the protein analysis protocol, and introduced a tandem mass tag (TMT) multiplexing technique. To demonstrate the typical outcome of the protocol, we used RapidAIM 2.0 to evaluate the effect of prebiotic kestose on ex vivo individual human gut microbiomes biobanked with five different workflows.
Results: We describe the protocol of RapidAIM 2.0 with extensive details on stool sample collection, biobanking, in vitro culturing and stimulation, sample processing, metaproteomics measurement, and data analysis. The analysis depth of 5,014 ± 142 protein groups per multiplexed sample was achieved. A test on five biobanking methods using RapidAIM 2.0 showed the minimal effect of sample processing on live microbiota functional responses to kestose.
Conclusions: Depth and reproducibility of RapidAIM 2.0 are comparable to previous manual label-free metaproteomic analyses. In the meantime, the protocol realizes culturing and sample preparation of 320 samples in six days, opening the door to extensively understanding the effects of xenobiotic and biotic factors on our internal ecology.
Deep Learning Method for Improving Rate of Penetration Prediction in Drilling
Authors: Urdaneta Carlos , Jeong Cheolkyun , Wu Xuqing , Chen Jiefu 
Published: April 2024

Summary
The urgent global need to reduce CO2 emissions necessitates the development of sustainable power generation sources. Geothermal power emerges as a renewable and dependable energy option, harnessing the Earth’s natural heat sources for electricity generation. Unlike other renewables, geothermal energy offers uninterrupted power, immune to weather conditions. However, its efficiency hinges on technological innovation, particularly in the challenging realm of geothermal drilling. Rate of penetration (ROP) is a crucial drilling performance metric, and this study explores how deep learning models, particularly transformers, can optimize ROP prediction. Leveraging data from Utah Frontier Observatory for Research in Geothermal Energy (FORGE), we analyze the relationship between drilling parameters and ROP. Traditional drilling optimization methods face limitations, as drilling dysfunctions can disrupt the linear relationship between ROP and weight on bit (WOB). We propose a dynamic approach that allows adapting drilling parameters in real time to optimize ROP. Our experiments investigate optimal sampling intervals and forecast horizons for ROP prediction. We find that a 60-second sampling interval maximizes the transformer model’s forecasting accuracy. Additionally, we explore retraining to fine-tune models for specific wells, improving forecasting performance. Our transformer-based ROP forecaster outperforms deep learning models, achieving a low overall 5.22% symmetrical mean average percentage error (SMAPE) over a forecast horizon of 10 minutes. This model offers opportunities for cost-effective drilling optimization, with real-time accuracy, speed, and scalability. Future work will focus on larger data sets and integration with drilling automation systems to further enhance the model’s practicality and effectiveness in the field.
The effectiveness of vitrectomy co-adjuvant intravitreal dexamethasone implant on visual outcome in patients with proliferative diabetic retinopathy: study protocol for a prospective randomized controlled trail
Authors: 赵 萌 , Chandra Aman , Xu Jun , Liu Lin , Li Jipeng 
Published: April 2024

Abstract

Background: Proliferative diabetic retinopathy (PDR) often leads to tractional retinal detachment and vitreous hemorrhage, requiring vitrectomy. Poor visual outcomes are commonly caused by macular edema and proliferative vitreous retinopathy after vitrectomy. Intravitreal dexamethasone implant has shown promise in improving visual function after vitrectomy for diabetic macular edema, but its role in vitrectomy in PDR treatment remains unexplored. This study aims to assess the effectiveness of vitrectomy combined with intravitreal dexamethasone implant for PDR patients.
Methods: We designed a single-blind, randomized controlled trial with 100 participants diagnosed with PDR requiring vitrectomy. Participants were randomly assigned to either the dexamethasone implant group or the control group. The dexamethasone implant group underwent vitrectomy combined with intravitreal dexamethasone implant, while the control group underwent vitrectomy alone. The single surgeon performed all the vitrectomy surgeries, the choice of intravitreal dexamethasone implant treatment was disclosed before the closure of scleral wounds. Primary and secondary outcomes were assessed at baseline, 4 weeks, and 8 weeks post-vitrectomy. Primary outcome measures included corrected visual acuity (Snellen visual chart) and central retinal thickness (optical coherence tomography OCT). Secondary outcomes included elevated intraocular pressure, post-vitrectomy hemorrhage, retinal detachment, and systemic complications requiring hospitalization.
Discussion: This protocol seeks to enhance our understanding of the effects of combined intravitreal dexamethasone implant with vitrectomy on visual outcomes and macular morphology changes in treating late complications of PDR.
The trail was registered at Chinese Clinical Trial Registry at May 11th 2022 with registration number ChiCTR2200059760.
Successful rechallenge twice with different EGFR-TKIs in a patient with lung adenocarcinoma after EGFR- TKI-induced grade 3 stomatitis and interstitial lung disease: a case report
Authors: Liu Xueni , Zhu Kejun , Xie Yanru , Huang Jianhui 
Published: April 2024

Abstract

Background:
Rechallenge with EGFR tyrosine kinase inhibitors (TKIs) can be successful as a result of different TKI adverse event profiles. Grade 3 stomatitis seriously affects a patient’s life and leads to drug discontinuation, which can affect survival. Serious adverse effects caused by EGFR-TKIs, such as interstitial lung disease (ILD), can be fatal. This study provides new treatment options for patients who develop grade 3 stomatitis or ILD following EGFR-TKI therapy.
Case Description:
We present the case of a 67-year-old female patient with stage IV adenocarcinoma involving an EGFR exon 19 deletion mutation who received gefitinib for three months and then discontinued treatment due to grade 3 stomatitis. Icotinib was readministered without any adverse events (AEs). After stable control for 14 months, new liver metastases appeared, and three cycles of pemetrexed and carboplatin plus bevacizumab were administered. Subsequent next-generation sequencing of plasma indicated an EGFR T790M mutation, and the patient subsequently received osimertinib for three months. However, as the patient developed osimertinib-induced grade 3 ILD, the TKIs were discontinued, and high-dose methylprednisolone was administered. After symptomatic remission, half-dose aumolertinib and steroid protection were administered. As there was no ILD recurrence, aumolertinib was increased to the standard dose in 1 month, and the tumor achieved a partial response (PR) .The progression-free survival (PFS) with aumolertinib was more than 17 months without obvious AEs.
Conclusions:
We report a case of successful rechallenge with two different EGFR-TKIs. Faced with serious adverse effects such as ILD, the rechallenge can be attempted after a thorough assessment of clinical benefits and potential risks.
Prediction of potential biomarkers and therapeutic targets of copper death in osteoarthritis
Authors: Jurat Jessore , Liu Xiao , Liang Pengfei , Cheng Long , Xia Jing , Wang Jialu , Qian Ping , Zhang Dongfang , Li Wenxuan 
Published: April 2024

Abstract
Osteoarthritis (OA) is a common degenerative joint disease characterized by articular cartilage destruction and synovial damage. The immune system has an impact on the development of OA. The infiltration of immune cells will cause the autoimmune reaction of osteoarthritis and disrupt the immune equilibrium in bone tissue. Recent studies have demonstrated that copper is crucial in regulating the immune system. Copper can also mediate cell death through a new cell death program by targeting the tricarboxylic acid cycle (TCA) circulating protein. However, no research has been conducted on the copper death gene regulation of OA immune response.The gene expression profiles—GSE55235, GSE82107, and GSE206848—were obtained from the GEO database. A total of 24 healthy and 27 OA joint synovial samples were screened for differentially expressed genes (DEGs) in combination with copper death-related genes and immune-related genes to conduct subsequent analyses.We have selected seven genes—NAMPT, EGFR, ADM, APOD, CD28, CXCL12, and MMP9—as potentially essential marker genes to regulate copper death. These marker genes are enriched in autophagy, lysosome, apoptosis, immune response, polysaccharide synthesis and metabolism, and signaling pathways of related diseases. The proportion of NKT cells in OA samples was significantly higher than that in the control group, whereas neutrophil expression was significantly lower than that in the healthy group. Finally, RT-PCR confirmed that the expressions of NAMPT and EGFR in the disease group were lower than those in the control group.We developed and validated the immune copper death DEGs model, which can accurately diagnose and characterize the biological changes of OA. Seven marker genes may also be potential targets of immunomodulatory therapy, including NAMPT and EGFR, which play an essential role in bone and joint, thereby providing prediction and theoretical support for the regulatory mechanism of copper death in osteoarthritis.