bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teilhabe von Menschen mit einer geistigen Beeinträchtigung in digitalisierten Lebensbereichen
Authors: Albrecht Joanna , Hüning Nadine 
Published: April 2024

ZusammenfassungDie Eingliederungshilfe ist in der fachlichen Arbeit in mehrfacher Weise mit der Mediatisierung konfrontiert. Die Lebensbereiche der Klienten wandeln sich und die sozialen Ungleichheiten werden über das Medienhandeln (re-)produziert. Zudem verändern sich mit der Digitalisierung Arbeitsprozesse sowie Erbringungsformen in der Eingliederungshilfe und folglich auch die Anforderungen an die Fachkräfte, die dazu unter anderem Medienkompetenzen und medienpädagogische Kompetenzen benötigen.
Ergebnisse
Authors: Albrecht Joanna , Hüning Nadine 
Published: April 2024

ZusammenfassungNachfolgend werden die Ergebnisse des sequenziellen Mixed-Methods-Studiendesigns entlang der angewandten Methoden aufgezeigt. Demnach werden zunächst die Erkenntnisse der literaturbasierten Definitions- und Modellentwicklung Digitaler Teilhabe von MgB (DDT1 und MDT1) dargelegt. Anschließend werden die Ergebnisse der empirischen Weiterentwicklung der Definition (DDT2) und des Modells Digitaler Teilhabe (MDT2–MDT4) dargestellt. Das Kapitel schließt mit der Erläuterung der Erkenntnisse zur Entwicklung und Prüfung des Erhebungsinstruments Digitaler Teilhabe von MgB in der Eingliederungshilfe (EIDT1–EIDT3) ab.
From conformal to confining field theories using holography
Authors: Fatemiabhari Ali , Nunez Carlos 
Published: April 2024

Abstract
We construct a new family of Type IIB backgrounds that are dual to five dimensional conformal field theories compactified and deformed by VEVs of certain operators. This generates an RG flow into a smooth background dual to non-SUSY gapped field theories in four dimensions. We study various holographic observables: a monotonic quantity associated with the number of degrees of freedom, Wilson loops that interpolate between conformal and confining behaviour with the possibility of screening, Entanglement Entropy, etc. We also give a prescription to compute the Holographic Complexity in this type of backgrounds and calculate the spectrum of spin-two glueballs of the field theories.
Normal modes of the stretched horizon: a bulk mechanism for black hole microstate level spacing
Authors: Krishnan Chethan , Pathak Pradipta S. 
Published: April 2024

Abstract
In 1984, ’t Hooft famously used a brickwall (aka stretched horizon) to compute black hole entropy up to a numerical pre-factor. This calculation is sometimes interpreted as due to the entanglement of the modes across the horizon, but more operationally, it is simply an indirect count of the semi-classical modes trapped between the stretched horizon and the angular momentum barrier. Because the calculation was indirect, it needed both the mass and the temperature of the black hole as inputs, to reproduce the area. A more conventional statistical mechanics calculation should be able to get the entropy, once the ensemble is specified (say via the energy, in a microcanonical setting). In this paper, we explicitly compute black hole normal modes in various examples, numerically as well as (in various regimes) analytically. The explicit knowledge of normal modes allows us to reproduce both the Hawking temperature as well as the entropy, once the charges are specified, making this a conventional statistical mechanics calculation. A quasi-degeneracy in the angular quantum numbers is directly responsible for the area scaling of the entropy, and is the key distinction between the Planckian black body calculation (volume scaling) and the ’t Hooftian calculation (area scaling). We discuss the (rotating) BTZ case in detail and match the thermodynamic quantities exactly. Schwarzschild and Kerr normal modes are discussed in less detail using near-horizon approximations. Our calculations reveal a new hierarchy in the angular quantum numbers, which we speculate is related to string theory.
Real time holography for higher spin theories
Authors: Hao Zezhuang 
Published: April 2024

Abstract
Real time holography is studied in the context of the embedding space formalism. In the first part of this paper, we present matching conditions for on-shell integer spin fields when going from Euclidean to Lorentzian signature on AdS background. Using the BTZ black hole as an example, we discuss various ways of lifting the physical solution from the AdS surface to the whole embedding space. The BTZ propagator for higher spin field is expressed elegantly in terms of the embedding coordinates. In the second part of the paper, we develop the proposed duality between higher spin theory and vector models. We obtain a specific map between the field configurations of these two theories in real time, so called Lorentzian AdS/CFT map. We conclude by exploring the matching conditions for higher spin fields satisfying the proposed bulk quadratic action. The physical and ghost modes can be treated independently during the Wick rotation; only physical modes are considered to be external modes.
Drag force and heavy quark potential in a rotating background
Authors: Chen Jun-Xia , Hou De-Fu , Ren Hai-Cang 
Published: April 2024

Abstract
We explored the gravity dual of a rotating quark-gluon plasma by transforming the boundary coordinates of the large black hole limit of Schwarchild-AdS5 metric. The Euler-Lagrange equation of the Nambu-Goto action and its solution become more complex than those without rotation. For small angular velocity, we obtained an analytical form of the drag force acting on a quark moving in the direction of the rotation axis and found it stronger than that without rotation. We also calculated the heavy quark potential under the same approximation. For the quarkonium symmetric with respect to the rotation axis, the depth of the potential is reduced by the rotation. For the quarkonium oriented in parallel to the rotation axis, the binding force is weakened and the force range becomes longer. We also compared our holographic formulation with others in the literature.
Impact of the timing of metformin administration on glycaemic and glucagon-like peptide-1 responses to intraduodenal glucose infusion in type 2 diabetes: a double-blind, randomised, placebo-controlled, crossover study
Authors: Xie Cong , Iroga Peter , Bound Michelle J. , Grivell Jacqueline , Huang Weikun , Jones Karen L. , Horowitz Michael , Rayner Christopher K. , Wu Tongzhi 
Published: April 2024

Abstract
Aims/hypothesis
Metformin lowers postprandial glycaemic excursions in individuals with type 2 diabetes by modulating gastrointestinal function, including the stimulation of glucagon-like peptide-1 (GLP-1). The impact of varying the timing of metformin administration on postprandial glucose metabolism is poorly defined. We evaluated the effects of metformin, administered at different intervals before an intraduodenal glucose infusion, on the subsequent glycaemic, insulinaemic and GLP-1 responses in metformin-treated type 2 diabetes.

Methods
Sixteen participants with type 2 diabetes that was relatively well-controlled by metformin monotherapy were studied on four separate days in a crossover design. On each day, participants were randomised to receive a bolus infusion of metformin (1000 mg in 50 ml 0.9% saline) via a nasoduodenal catheter at t = −60, −30 or 0 min (and saline at the other timepoints) or saline at all timepoints (control), followed by an intraduodenal glucose infusion of 12.56 kJ/min (3 kcal/min) at t = 0–60 min. The treatments were blinded to both participants and investigators involved in the study procedures. Plasma glucose, insulin and total GLP-1 levels were measured every 30 min between t = −60 min and t = 120 min.

Results
There was a treatment-by-time interaction for metformin in reducing plasma glucose levels and increasing plasma GLP-1 and insulin levels (p<0.05 for each). The reduction in plasma glucose levels was greater when metformin was administered at t = −60 or −30 min vs t = 0 min (p<0.05 for each), and the increases in plasma GLP-1 levels were evident only when metformin was administered at t = −60 or −30 min (p<0.05 for each). Although metformin did not influence insulin sensitivity, it enhanced glucose-induced insulin secretion (p<0.05), and the increases in plasma insulin levels were comparable on the 3 days when metformin was given.

Conclusions/interpretation
In well-controlled metformin-treated type 2 diabetes, glucose-lowering by metformin is greater when it is given before, rather than with, enteral glucose, and this is associated with a greater GLP-1 response. These observations suggest that administration of metformin before meals may optimise its effect in improving postprandial glycaemic control.

Trial registration
www.anzctr.org.au ACTRN12621000878875

Funding
The study was not funded by a specific research grant.

Graphical Abstract
Using rhetorical strategies to design prompts: a human-in-the-loop approach to make AI useful
Authors: Ranade Nupoor , Saravia Marly , Johri Aditya 
Published: April 2024

AbstractThe growing capabilities of artificial intelligence (AI) word processing models have demonstrated exceptional potential to impact language related tasks and functions. Their fast pace of adoption and probable effect has also given rise to controversy within certain fields. Models, such as GPT-3, are a particular concern for professionals engaged in writing, particularly as their engagement with these technologies is limited due to lack of ability to control their output. Most efforts to maximize and control output rely on a process known as prompt engineering, the construction and modification of the inputted prompt with expectation for certain outputted or desired text. Consequently, prompt engineering has emerged as an important consideration for research and practice. Previous conceptions of prompt engineering have largely focused on technical and logistic modifications to the back-end processing, remaining inaccessible and, still, limited for most users. In this paper, we look to the technical communication field and its methods of text generation—the rhetorical situation—to conceptualize prompt engineering in a more comprehensible way for its users by considering the context and rhetoric. We introduce a framework, consisting of a formula, to prompt engineering, which demands all components of the rhetorical situation be present in the inputted prompt. We present discussions on the future of AI writing models and their use in both professional and educational settings. Ultimately, this discussion and its findings aim to provide a means of integrating agency and writer-centric methods to AI writing tools to advance a more human-in-the-loop approach. As the use of generative AI and especially NLP-based technologies become common across societal functions, the use of prompt engineering will play a crucial role not just in adoption of the technology, but also its productive and responsible use.
Effects of the nerve agent VX on hiPSC-derived motor neurons
Authors: Schaefers Catherine , Schmeißer Wolfgang , John Harald , Worek Franz , Rein Theo , Rothmiller Simone , Schmidt Annette 
Published: March 2024

AbstractPoisoning with the organophosphorus nerve agent VX can be life-threatening due to limitations of the standard therapy with atropine and oximes. To date, the underlying pathomechanism of VX affecting the neuromuscular junction has not been fully elucidated structurally. Results of recent studies investigating the effects of VX were obtained from cells of animal origin or immortalized cell lines limiting their translation to humans. To overcome this limitation, motor neurons (MN) of this study were differentiated from in-house feeder- and integration-free-derived human-induced pluripotent stem cells (hiPSC) by application of standardized and antibiotic-free differentiation media with the aim to mimic human embryogenesis as closely as possible. For testing VX sensitivity, MN were initially exposed once to 400 µM, 600 µM, 800 µM, or 1000 µM VX and cultured for 5 days followed by analysis of changes in viability and neurite outgrowth as well as at the gene and protein level using µLC-ESI MS/HR MS, XTT, IncuCyte, qRT-PCR, and Western Blot. For the first time, VX was shown to trigger neuronal cell death and decline in neurite outgrowth in hiPSC-derived MN in a time- and concentration-dependent manner involving the activation of the intrinsic as well as the extrinsic pathway of apoptosis. Consistent with this, MN morphology and neurite network were altered time and concentration-dependently. Thus, MN represent a valuable tool for further investigation of the pathomechanism after VX exposure. These findings might set the course for the development of a promising human neuromuscular test model and patient-specific therapies in the future.
Unconditional uniqueness and non-uniqueness for Hardy–Hénon parabolic equations
Authors: Chikami Noboru , Ikeda Masahiro , Taniguchi Koichi , Tayachi Slim 
Published: April 2024

AbstractWe study the problems of uniqueness for Hardy–Hénon parabolic equations, which are semilinear heat equations with the singular potential (Hardy type) or the increasing potential (Hénon type) in the nonlinear term. To deal with the Hardy–Hénon type nonlinearities, we employ weighted Lorentz spaces as solution spaces. We prove unconditional uniqueness and non-uniqueness, and we establish uniqueness criterion for Hardy–Hénon parabolic equations in the weighted Lorentz spaces. The results extend the previous works on the Fujita equation and Hardy equations in Lebesgue spaces.
Efficacy of flexible ureterorenoscopy with holmium laser in the management of calyceal diverticular calculi
Authors: Zeng Shi-Ping , Sun Yi-Fei , Yu Han-Yang , Yang Jian , Deng Ke-Fei 
Published: March 2024

AbstractThe purpose of this study was to evaluate the efficacy and safety of flexible ureteroscopy with holmium laser lithotripsy in the management of calyceal diverticular calculi. In this study, we retrospectively analyzed the clinical data of 27 patients with calyceal diverticular calculi admitted to the Department of Urology of the Zigong First People’s Hospital from May 2018 to May 2021. Intraoperatively, the diverticular neck was found in all 27 patients, but flexible ureterorenoscopy lithotripsy was not performed in 2 cases because of the slender diverticular neck, and the success rate of the operation was 92.6%. Of the 25 patients with successful lithotripsy, the mean operative time was 76.9 ± 35.5 (43–200) min. There were no serious intraoperative complications such as ureteral perforation, mucosal avulsion, or hemorrhage. Postoperative minor complications (Clavien classification I-II) occurred in 4 (16%) patients. The mean hospital stay was 4.4 ± 1.7 (3–12) days. The stone-free rate was 80% at the 1-month postoperative follow-up. After the second-stage treatment, the stone-free rate was 88%. In 22 cases with complete stone clearance, no stone recurrence was observed at 5.3 ± 2.6 (3–12) months follow-up. This retrospective study demonstrated that flexible ureterorenoscopy with holmium laser is a safe and effective choice for the treatment of calyceal diverticular calculi, because it utilizes the natural lumen of the human body and has the advantages of less trauma, fewer complications, and a higher stone-free rate.
The radiomics nomogram predicts the prognosis of pancreatic cancer patients with hepatic metastasis after chemoimmunotherapy
Authors: Lu Wenxin , Wu Guangyu , Miao Xianyuan , Ma Jingyu , Wang Yanling , Xu Haiyan , Shentu Daiyuan , Xue Shengbai , Xia Qing , Wang Yu , Wang Liwei 
Published: March 2024

Abstract
Objective
To construct a prognostic model based on MR features and clinical data to evaluate the progression free survival (PFS), overall survival (OS) and objective response rate (ORR) of pancreatic cancer patients with hepatic metastases who received chemoimmunotherapy.

Methods
105 pancreatic cancer patients with hepatic metastases who received chemoimmunotherapy were assigned to the training set (n = 52), validation set (n = 22), and testing set (n = 31). Multi-lesion volume of interest were delineated, multi-sequence radiomics features were extracted, and the radiomics models for predicting PFS, OS and ORR were constructed, respectively. Clinical variables were extracted, and the clinical models for predicting PFS, OS and ORR were constructed, respectively. The nomogram was jointly constructed by radiomics model and clinical model.

Result
The ORR exhibits no significant correlation with either PFS or OS. The area under the curve (AUC) of nomogram for predicting 6-month PFS reached 0.847 (0.737–0.957), 0.786 (0.566–1.000) and 0.864 (0.735–0.994) in the training set, validation set and testing set, respectively. The AUC of nomogram for predicting 1-year OS reached 0.770 (0.635–0.906), 0.743 (0.479–1.000) and 0.818 (0.630–1.000), respectively. The AUC of nomogram for predicting ORR reached 0.914 (0.828–1.00), 0.938 (0.840–1.00) and 0.846 (0.689–1.00), respectively.

Conclusion
The prognostic models based on MR imaging features and clinical data are effective in predicting the PFS, OS and ORR of chemoimmunotherapy in pancreatic cancer patients with hepatic metastasis, and can be used to evaluate the prognosis of patients.
Prenatal inflammation exposure accelerates lung cancer tumorigenesis in offspring mouse: possible links to IRE1α/XBP1-mediated M2-like polarization of TAMs and PD-L1 up-expression
Authors: Ma Jingbo , Tan Jian , Zhang Weiqiang , Bai Miaochun , Liu Keqiang 
Published: March 2024

Abstract
Background
Prenatal inflammation exposure (PIE) can increase the disease susceptibility in offspring such as lung cancer. Our purpose was to investigate the mechanisms of PIE on lung cancer.

Methods
Prenatal BALB/c mice were exposed to lipopolysaccharide (LPS), and then, their offspring were intraperitoneally instilled with urethane to establish the two-stage lung cancer carcinogenesis model. At the 48 weeks of age, the offspring mice were killed and lung tissues were collected for HE, immunohistochemistry, immunofluorescence, and Luminex MAGPIX®-based assays. CD11b + F4/80 + tumor-associated macrophages (TAMs) were sorted out from lung tumor tissues by cell sorting technique. Flow cytometry was employed to evaluate the extent of M2-like polarization of TAMs and PD-L1 expression.

Results
The offspring of PIE mice revealed more lung lesion changes, including atypical hyperplasia and intrapulmonary metastases. The number of lung nodules, lung organ index, and PCNA, MMP-9 and Vimentin positive cells in lung tissue of PIE group were higher than those of Control group. The increases of mRNA encoding M2 macrophage markers and cytokines in offspring of prenatal LPS-treated mice confirmed the induced effect of PIE on macrophage polarization. Additionally, PIE treatment increased the percentage of CD163 + CD206 + cells in the sorted TAMs. Importantly, endoplasmic reticulum (ER) stress-markers like GRP78/BIP and CHOP, p-IRE1α and XBP1s, and PD-L1 were up-regulated in TAMs from PIE group. Besides, we also observed that IRE1α inhibitor (KIRA6) reversed the M2-like TAMs polarization and metastasis induced by PIE.

Conclusions
IRE1α/XBP1-mediated M2-like TAMs polarization releases the pro-tumorigenic cytokines and PD-L1 expression, which may be the regulatory mechanism of accelerating lung cancer in offspring of mice undergoing PIE.
Is it possible to achieve multiplanar correction of complex deformities around the knee in children and adolescents using a monolateral external fixator?
Authors: Elbarbary Hassan , Abdelmohsen Ahmed , Zein Abo-Bakr , Arafa Amr , Hegazy Mohamed , Yaseen Ahmed , Afifi Ahmed 
Published: April 2024

Abstract
Purpose
To present the technique of correction of multiplanar deformities around the knee in children and adolescents using the monolateral external fixator. Also, to evaluate the results of the technique regarding radiological correction, time to union, and possible complications.

Methods
A total of 29 patients (47 limbs) were prospectively included in the study (14 males and 15 females). Their median age was 13 years (range, 7–17). All patients had at least a 2-plane deformity around the knee which was corrected using a monolateral external fixator. The primary outcome measure was deformity correction (correction of mechanical axis deviation (MAD) in both the coronal and sagittal planes with correction of rotational deformities). The secondary outcome measures included bony union, radiographic, and functional results (assessed by using the Association for the Study and Application of the Method of Ilizarov (ASAMI) score).

Results
The median pre-operative MAD improved from 6.3 to 0.4 cm post-operatively. According to the ASAMI scoring system, the radiographic scoring was excellent in all cases (100%), and the functional scoring was excellent in 22 cases (89.7%) and good in three cases (10.3%).

Conclusion
The simple monolateral fixator can be an effective tool for multiplanar correction of complex deformities around the knee without limb length discrepancy.
Relaxed notions of Condorcet-consistency and efficiency for strategyproof social decision schemes
Authors: Brandt Felix , Lederer Patrick , Romen René 
Published: April 2024

AbstractSocial decision schemes (SDSs) map the preferences of a group of voters over some set of m alternatives to a probability distribution over the alternatives. A seminal characterization of strategyproof SDSs by Gibbard (Econometrica 45(3):665–681, 1977) implies that there are no strategyproof Condorcet extensions and that only random dictatorships satisfy ex post efficiency and strategyproofness. The latter is known as the random dictatorship theorem. We relax Condorcet-consistency and ex post efficiency by introducing a lower bound on the probability of Condorcet winners and an upper bound on the probability of Pareto-dominated alternatives, respectively. We then show that the randomized Copeland rule is the only anonymous, neutral, and strategyproof SDS that guarantees the Condorcet winner a probability of at least 2/m. Secondly, we prove a continuous strengthening of Gibbard’s random dictatorship theorem: the less probability we put on Pareto-dominated alternatives, the closer to a random dictatorship is the resulting SDS. Finally, we show that the only anonymous, neutral, and strategyproof SDSs that maximize the probability of Condorcet winners while minimizing the probability of Pareto-dominated alternatives are mixtures of the uniform random dictatorship and the randomized Copeland rule.