bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Results for Children With High-Risk Neuroblastoma Treated on a Randomized Trial of Myeloablative Therapy Followed by 13-cis-Retinoic Acid: A Children's Oncology Group Study
Authors: Matthay Katherine K. , Reynolds C. Patrick , Seeger Robert C. , Shimada Hiroyuki , Adkins E. Stanton , Haas-Kogan Daphne , Gerbing Robert B. , London Wendy B. , Villablanca Judith G. 
Published: January 2009

Purpose We assessed the long-term outcome of patients enrolled on CCG-3891, a high-risk neuroblastoma study in which patients were randomly assigned to undergo autologous purged bone marrow transplantation (ABMT) or to receive chemotherapy, and subsequent treatment with 13-cis-retinoic acid (cis-RA). Patients and Methods Patients received the same induction chemotherapy, with random assignment (N = 379) to consolidation with myeloablative chemotherapy, total-body irradiation, and ABMT versus three cycles of intensive chemotherapy. Patients who completed consolidation without disease progression were randomly assigned to receive no further therapy or cis-RA for 6 months. Results The event-free survival (EFS) for patients randomly assigned to ABMT was significantly higher than those randomly assigned to chemotherapy; the 5-year EFS (mean ± SE) was 30% ± 4% versus 19% ± 3%, respectively (P = .04). The 5-year EFS (42% ± 5% v 31% ± 5%) from the time of second random assignment was higher for cis-RA than for no further therapy, though it was not significant. The 5-year overall survival (OS) from the second random assignment of patients who underwent both random assignments and who were assigned to ABMT/cis-RA was 59% ± 8%; for ABMT/no cis-RA, it was 41% ± 7%; for continuing chemotherapy/cis-RA, it was 38% ± 7%; and for chemotherapy/no cis-RA, it was 36% ± 7%. Conclusion Myeloablative therapy and autologous hematopoietic cell rescue result in significantly better 5-year EFS than nonmyeloablative chemotherapy; neither myeloablative therapy with autologous hematopoietic cell rescue nor cis-RA given after consolidation therapy significantly improved OS.
Overall Genomic Pattern Is a Predictor of Outcome in Neuroblastoma
Authors: Janoueix-Lerosey Isabelle , Schleiermacher Gudrun , Michels Evi , Mosseri Véronique , Ribeiro Agnès , Lequin Delphine , Vermeulen Joëlle , Couturier Jérôme , Peuchmaur Michel , Valent Alexander , Plantaz Dominique , Rubie Hervé , Valteau-Couanet Dominique , Thomas Caroline , Combaret Valérie , Rousseau Raphaël , Eggert Angelika , Michon Jean , Speleman Frank , Delattre Olivier 
Published: January 2009

Purpose For a comprehensive overview of the genetic alterations of neuroblastoma, their association and clinical significance, we conducted a whole-genome DNA copy number analysis. Patients and Methods A series of 493 neuroblastoma (NB) samples was investigated by array-based comparative genomic hybridization in two consecutive steps (224, then 269 patients). Results Genomic analysis identified several types of profiles. Tumors presenting exclusively whole-chromosome copy number variations were associated with excellent survival. No disease-related death was observed in this group. In contrast, tumors with any type of segmental chromosome alterations characterized patients with a high risk of relapse. Patients with both numerical and segmental abnormalities clearly shared the higher risk of relapse of segmental-only patients. In a multivariate analysis, taking into account the genomic profile, but also previously described individual genetic and clinical markers with prognostic significance, the presence of segmental alterations with (HR, 7.3; 95% CI, 3.7 to 14.5; P < .001) or without MYCN amplification (HR, 4.5; 95% CI, 2.4 to 8.4; P < .001) was the strongest predictor of relapse; the other significant variables were age older than 18 months (HR, 1.8; 95% CI, 1.2 to 2.8; P = .004) and stage 4 (HR, 1.8; 95% CI, 1.2 to 2.7; P = .005). Finally, within tumors showing segmental alterations, stage 4, age, MYCN amplification, 1p and 11q deletions, and 1q gain were independent predictors of decreased overall survival. Conclusion The analysis of the overall genomic pattern, which probably unravels particular genomic instability mechanisms rather than the analysis of individual markers, is essential to predict relapse in NB patients. It adds critical prognostic information to conventional markers and should be included in future treatment stratification.
Effect of Roux-en-Y Gastric Bypass Surgery on the Sex Steroids and Quality of Life in Obese Men
Authors: Hammoud Ahmad , Gibson Mark , Hunt Steven C. , Adams Ted D. , Carrell Douglass T. , Kolotkin Ronette L. , Meikle A. Wayne 
Published: January 2009

Abstract
Context: The effect of bariatric surgery on the reproductive function of obese men is not entirely elucidated.
Objective: The aim of the study was to define the effect of Roux-En-Y gastric bypass surgery on the reproductive hormones and sexual function in obese men.
Design and Setting: The cohort was followed for 2 yr at a clinical research center.
Patients: Sixty-four severely obese men (22 who had gastric bypass surgery and 42 controls) participated in the study.
Intervention(s): Anthropometrics [weight, body mass index (BMI), and percentage body fat] and reproductive hormones were measured. The sexual quality of life was assessed using the Impact of Weight on the Quality Of Life-Lite questionnaire.
Main Outcome Measure(s): Reproductive hormones and sexual quality of life were measured.
Results: The mean age was 48.9 ± 1.2 yr. At baseline, mean weight was 333.0 ± 7.1 lb, BMI was 46.2 ± 0.9 kg/m2, and total testosterone was 339.9 ± 21.32 ng/dl. BMI correlated positively with estradiol and negatively with total and free testosterone. Indices of dissatisfaction with sexual quality of life correlated positively with measures of obesity. Difficult sexual performance and low sexual desire correlated negatively with free and total testosterone (r = −0.273, P = 0.038; and r = −0.267, P = 0.042, respectively). After 2 yr, the gastric bypass surgery group had a significant decrease in BMI (−16.6 ± 1.2 vs. −0.46 ± 0.51 kg/m2) and estradiol (−8.1 ± 2.4 vs. 1.6 ± 1.4 pg/ml) and had an increase in total testosterone (310.8 ± 47.6 vs. 14.2 ± 15.3 ng/dl) and free testosterone (45.2 ± 5.1 vs. −0.4 ± 3.0 pg/ml). Sexual quality of life was improved after gastric bypass surgery.
Conclusion: Hormonal alterations and diminished sexual quality of life among obese men are related to degree of obesity, and both are improved after gastric bypass surgery.
Systematic Review of Early Intensive Behavioral Interventions for Children With Autism
Authors: Howlin Patricia , Magiati Iliana , Charman Tony 
Published: January 2009

Abstract
Recent reviews highlight limitations in the evidence base for early interventions for children with autism. We conducted a systematic review of controlled studies of early intensive behavioral interventions (EIBI) for young children with autism. Eleven studies met inclusion criteria (including two randomized controlled trials). At group level, EIBI resulted in improved outcomes (primarily measured by IQ) compared to comparison groups. At an individual level, however, there was considerable variability in outcome, with some evidence that initial IQ (but not age) was related to progress. This review provides evidence for the effectiveness of EIBI for some, but not all, preschool children with autism.
Gender Differences in Psychiatric Diagnoses Among Inpatients With And Without Intellectual Disabilities
Authors: Lunsky Yona , Bradley Elspeth A. , Gracey Carolyn D. , Durbin Janet , Koegl Chris 
Published: January 2009

Abstract
There are few published studies on the relationship between gender and psychiatric disorders in individuals with intellectual disabilities. Adults (N = 1,971) with and without intellectual disabilities who received inpatient services for psychiatric diagnosis and clinical issues were examined. Among individuals with intellectual disabilities, women were more likely to have a diagnosis of mood disorder and sexual abuse history; men were more likely to have a substance abuse diagnosis, legal issues, and past destructive behavior. Gender difference patterns found for individuals with intellectual disabilities were similar to those of persons without intellectual disabilities, with the exception of eating disorder and psychotic disorder diagnoses. Gender issues should receive greater attention in intellectual disabilities inpatient care.
Building the Case for Brief Psychointerventions in the Treatment of Specific Phobias in Children and Adolescents
Authors: Flatt Natalie , King Neville 
Published: January 2009

AbstractSpecific phobias are one of the most prevalent childhood anxiety disorders. Research suggests that phobias in children, such as animal or situational phobias, lead to significant impairments in peer relations, social and academic competence. Hence it is imperative to treat phobias within children and adolescents early to avoid more serious, engrained symptoms later in the lifespan. This review focuses on traditional exposure-based cognitive–behavioural therapies, and the more recent one-session exposure therapy for phobia treatment (Ost, 1987), a procedure that has only begun to be administered to children. Further, controlled trials evaluating the efficacy of 1-session exposure therapy with phobic children are urgently required. We also address challenges for researchers using psycho-education to control nonspecific treatment effects.
Cognitive Behavioural Treatment of Perfectionism: A Single Case Experimental Design Series
Authors: Egan Sarah J. , Hine Paula 
Published: January 2009

AbstractPerfectionism can maintain depression, anxiety and eating disorders, yet few studies have evaluated treatments for perfectionism. This study examined the effectiveness of individual cognitive behaviour therapy (CBT) in treating perfectionism in four adults with a diagnosis of either an anxiety disorder or depression. The study used an A-B single case experimental design series with follow-up, and a 3-week pre- and postbaseline phase. Treatment involved 8 sessions and a 2-week follow-up session. Visual inspection of data revealed downward trends in overall perfectionism and clinically significant decreases in perfectionism for two participants. No clinically significant reductions were observed in depressive or anxious symptomatology. CBT for perfectionism warrants further investigation.
Atherosclerotic risk factors and complications in patients with non-functioning adrenal adenomas treated with or without adrenalectomy: a long-term follow-up study
Authors: Sereg Márta , Szappanos Ágnes , Tőke Judit , Karlinger Kinga , Feldman Karolina , Kaszper Éva , Varga Ibolya , Gláz Edit , Rácz Károly , Tóth Miklós 
Published: January 2009

ObjectiveDespite the increased prevalences of hypertension, type 2 diabetes mellitus (T2DM), hyperlipidemy, and obesity in patients with non-functioning adrenal adenomas (NFAAs), there is a paucity of data on long-term atherosclerotic morbidity as well as the long-term cardiovascular effects of adrenalectomy in these patients.Design, patients, and methodsThis retrospective study includes the results of baseline and follow-up investigations of 125 patients (29 males and 96 females; mean age 60.1 years) with NFAAs referred for endocrine evaluation between 1990 and 2001. Of the 125 patients, 47 underwent unilateral adrenalectomy, while 78 patients were followed conservatively. These patients were reinvestigated after a mean follow-up time of 9.1 (5–16) years in 2006, with special emphasis on laboratory and other atherosclerotic risk factors (ARF), vascular events, and interventions.ResultsThe prevalences of hypertension, impaired glucose tolerance or T2DM, hyperlipidemy, and obesity were 82, 43, 58, and 50%, and 89, 58, 82, and 50% at baseline and follow-up, respectively. None of the investigated ARF prevalences were different between patients treated and not treated with adrenalectomy, and between patients with and without subclinical Cushing's syndrome. The prevalences of angina pectoris, acute myocardial infarction, coronary, and peripheral arterial interventions or cerebrovascular stroke did not differ significantly between patients treated and not treated with adrenalectomy.ConclusionOur study confirms previous investigations reporting markedly increased prevalences of various ARF in patients with NFAAs. Adrenalectomy performed in these patients failed to decrease the prevalence of ARF and atherosclerotic morbidity.
Presence of pituitary adenylate cyclase activating polypeptide-38 in human plasma and milk
Authors: Borzsei Rita , Mark Laszlo , Tamas Andrea , Bagoly Terez , Bay Csaba , Csanaky Katalin , Banki Eszter , Kiss Peter , Vaczy Alexandra , Horvath Gabriella , Nemeth Jozsef , Szauer Edit , Helyes Zsuzsanna , Reglodi Dora 
Published: January 2009

ObjectivePituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic and multifunctional neuropeptide widely distributed throughout the body. It is involved in the regulation of various physiological and pathophysiological processes, such as reproduction, thermoregulation, motor activity, brain development, neuronal survival, inflammation and pain. Since little is known about its distribution in humans, our aim was to examine PACAP-38 in human plasma. Furthermore, based on the presence of vasoactive intestinal peptide, structurally the closest to PACAP, in milk and PACAP and its receptors in the mammary gland, our aim was to study PACAP-38 in human milk.Design and methodsThe presence of PACAP-38 was determined by mass spectrometry in plasma samples from healthy male and female volunteers (age: 20–40), as well as in plasma and milk samples from lactating women (age: 20–35). PACAP concentration was measured with a specific and sensitive RIA.ResultsOur results revealed that PACAP-38 is present in human plasma, its concentration is relatively stable in healthy volunteers and it is not significantly altered by gender, age, food intake or hormonal cycle in females. However, PACAP-38 plasma levels significantly increased in lactating women having 1–6 month-old babies. Moreover, this study is the first which provides evidence for the presence of PACAP-38 in the human milk with levels 5–20-fold greater in the milk whey than in the respective plasma samples.ConclusionsWe found PACAP-38 in human plasma and its increase during the first 6 months of the lactation period. A prominent, nearly 10-fold higher concentration of this peptide was detected in human milk. Based on the literature, several important actions of milk-derived PACAP-38 can be suggested such as mammary gland proliferation, nutrient transfer as well as regulation of growth/differentiation of certain tissues of the neonates. The novelty of the present descriptive data provides a basis for further investigations on the mechanism of PACAP-38 secretion in human milk and its functional significance.
Effect of testosterone replacement therapy on arterial stiffness in older hypogonadal men
Authors: Yaron Marianna , Greenman Yona , Rosenfeld Joseph B , Izkhakov Elena , Limor Rona , Osher Etty , Shenkerman Galina , Tordjman Karen , Stern Naftali 
Published: January 2009

ObjectiveTo assess arterial stiffness in a cohort of hypogonadal males and to investigate the effect of testosterone replacement therapy on arterial properties in this specific group.DesignEighteen male patients with untreated acquired hypogonadism due to either adult-onset idiopathic hypogonadotropic hypogonadism (n=9) or pituitary tumor (n=9) and 12 age-, sex, and weight-matched eugonadal healthy controls were recruited for the study. Arterial properties, plasma glucose, lipid profile, total, and bioavailable testosterone (BT) levels were measured in fasting state. In the hypogonadal subjects, the effect of transdermal testosterone replacement therapy on arterial properties was studied by repeat noninvasive measurements at baseline, as well as 48 h and 90 days following the initiation of treatment.MethodsArterial stiffness was evaluated using applanation tonometry and pulse wave analysis by three different standard devices that assess various measures of arterial stiffness: pulse wave velocity (PWV), augmentation index (AIx), and large/small artery compliance (C1 and C2).ResultsAge- and blood pressure-adjusted PWV was significantly higher in hypogonadal men (8.90±2.29 vs 6.78±1.16 m/s in the control group;P=0.025). Testosterone therapy increased BT level from 2.01±1.04 to 4.68±2.43 and 7.83±6.2 nmol/l after 48 h and 3 months respectively (P=0.001). PWV decreased from 8.9±2.29 to 8.24±1.39 and 8.25±1.82 m/s after 48 h and 3 months of treatment respectively (P=0.03).ConclusionsMale hypogonadism is associated with increased PWV, which is rapidly but incompletely ameliorated by normalization of circulating testosterone levels.
65.4:Invited Paper: Key Human Visual System Components as Applied to Display Algorithms
Authors: Daly Scott 
Published: January 2009

AbstractIn most display applications, the final step is the viewing by human observers, so it is only logical to use current quantitative knowledge of the visual system in the design of imaging and display algorithms. This talk will cover key human visual system attributes, their modeling as separate components, and how they have been used in our labs to design new display algorithms and fine‐tune existing approaches. Some of the resulting algorithms described will include: motion‐adaptive backlight flashing, skin‐cognizant color mapping, two‐spatial channel architecture for color mapping and decontouring, bit‐depth extension, subpixel subsampling, and wavelet compression. The talk will also cover the new challenges that arise in very large (>100″) and bright (>500 cd/m∧2) displays, in terms of peripheral sensitivity and improved smooth pursuit eye movement capability.
66.4: Effects of Surface Treatment and Reflectance on Legibility and Visual Fatigue in Reflective‐type Displays
Authors: Lin Yu‐Ting , Lin Po‐Hung , Hwang Sheue‐Ling , Jeng Shie‐Chang , Lin Yan‐Rung 
Published: January 2009

AbstractInfluences of surface treatment and reflectance of reflective‐type displays on legibility and visual fatigue were studied. The results showed that the compound surface treatment of anti‐reflection and anti‐glare (ARC) exhibited better visual performance. The results also validated that a higher reflectance could improve legibility and reduce users' visual fatigue.
67.1: Active Matrix Electronic Paper with Silver Electrodeposition
Authors: Kokeguchi Noriyuki , Hakii Takeshi , Kishinami Katsuya , Hashimoto Kiyofumi , Okada Masakazu , Izumi Tomoo , Masazumi Naoki , Miyai Mitsuyoshi , Yoneda Shuji 
Published: January 2009

AbstractElectronic paper (3.5 inch & 113 ppi) driven by active‐matrix using silver electrodeposition has been developed. It has a reflectivity of at least 60%, and a contrast ratio of at least 20, resulting in realizing visibility equivalent to paper. By discovering a new halogen‐free silver salt electrolyte composition, driving stability, a gray color tone, and bi‐stability have been considerably improved.
67.4: Defect Loops in the Zenithal Bistable Display
Authors: Day Sally E. , Willman Eero , James Richard , Fernández F. Aníbal 
Published: January 2009

AbstractThe liquid crystal structure in the Zenithal Bistable Display contains defect loops that stabilise the two states. Three‐dimensional modeling of the Zenithal Bistable Display has been performed using a realistic representation of the grating surface profile. Stabilization of the defects loops provided by “slips” in the grating surface is investigated.
69.2: New R2PAT Printing Method for Fabricating TFT Electrodes
Authors: Tanaka Masanobu , Ishihara Hirotsugu , Shimamura Toshiki , Machida Akio , Kamei Takahiro , Ogawa Masataka 
Published: January 2009

AbstractWe have developed a low contact pressure Residual ink Removed Pattern Transfer (R2PAT) printing method which allows fully additive, vacuum‐free TFT electrode fabrication. A 900nm resolution and ±1um alignment accuracy has been achieved. A TFT fabricated using this method had demonstrated 33.9 cm2/Vs mobility and a 108 Ion/Ioff ratio.
69.4: Invited Paper: SELAX Technology for Poly‐Si TFTs Integrated with Amorphous‐Si TFTs
Authors: Kaitoh Takuo , Miyazawa Toshio , Miyake Hidekazu , Noda Takeshi , Sakai Takeshi , Owaku Yoshiharu , Saitoh Terunori 
Published: January 2009

AbstractWe developed an advanced LTPS (A‐LTPS) manufacturing process, which enables production of LTPS‐TFTs by utilizing the conventional a‐Si TFT production line. The a‐Si TFT process was combined with selectively enlarging laser crystallization (SELAX) technology to improve the carrier mobility in the region where the peripheral circuits are to be fabricated. A 2.4‐inch IPS‐LCD panel for personal digital assistant use was successfully fabricated using the developed technology.
70.1: LED‐Illuminated Pico Projector Architectures
Authors: Darmon Denis , McNeil John R. , Handschy Mark A. 
Published: January 2009

AbstractOptical architecture choices optimize pico‐projection engines for battery‐powered embedded applications and wall‐plug‐powered stand‐alone applications. Embedded engines offer power efficiencies above 6 lm/W, while stand‐alone systems offer luminous outputs up to 110 lm.
70.4: Invited Talk: Light Engine Design and Manufacturing Development in Projection System
Authors: Chen Sung‐Nan , Chen Mei‐Ling , Chen S‐Wei , Chen Chao‐Shun 
Published: January 2009

AbstractThe development of projection system in terms of various light sources during past years accumulated a progressive achievement, which may broaden the projection application and bridge a new era of effective manufacturing process.By categorize the light sources and innovative illumination design respectively; this Article will digest (i) traditional UHP type lamp to solid state light source in relation to various integrator design in illumination, (ii) LED, focus on lighting efficiency utilization in LED light engine development and (iii) the evolutional de‐speckle and cooling methods are the core challenges and accomplishment in laser illumination design.
10.1: Distinguished Paper: Evaluation of Moving‐Line Contrast Degradation without Motion
Authors: Becker Michael E. 
Published: January 2009

AbstractThis paper introduces a method for evaluation of the contrast of a moving lattice (grille) pattern without imaging data acquisition and image analysis. We characterize the dynamic performance of the display under test in terms of periodic responses followed by evaluation of the dynamic contrast from the temporal variation of luminance. It thus becomes possible to simulate moving grille patterns with any pitch, arbitrary gray‐levels and speed of translation by measuring the corresponding temporal luminance variations at a fixed location. This approach is attractive due to reduced instrumental efforts and the transparent evaluation based on suitable spatial contrast sensitivities.
71.4: High Efficiency and/or Low Cost LED Backlight System for Color Sequential Technique in Color Filter‐Less LCD System
Authors: Hsieh Chun‐Yu , Wang Shih‐Jung , Lee Yu‐Huei , Chen Ke‐Horng , Ho Ming‐Tsung 
Published: January 2009

AbstractThis paper proposes a design methodology for implementing a high efficiency and/or a low cost RGB backlight module in color sequential notebook computers' display. A RGB LED driver composed of an asynchronous 1.5MHz DC/DC boost converter with dual loop control is fabricated by TSMC 0.25 μm BCD 40V to generate 17V or 21V output voltage to turn on more than 6 series‐red, 6 series‐green, or series‐blue LEDs at the same time for the notebooks' backlight. Besides, charge‐recycling technique is used to restore extra energy at the output node when switching to different forwarding light emitting diodes (LEDs) and release the energy next time. The total power consumption of a 15.4′ LCD panel of a notebook computer can be reduced from 5W to about 2–3W.