bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐Performance Mg–O2 Batteries Enabled by Electrospinning PVDF‐HFP‐Based Quasi‐Solid‐State Polymer Electrolyte
Authors: Rasupillai Dharmaraj Vasantan , Maurya Dheeraj Kumar , Sarkar Ayan , Su Hsiu‐Hui , Chen Yi‐An , Chen Han‐Chen , Lin Yu‐Ping , Chung Ren‐Jei , Liu Ru‐Shi 
Published: February 2025

AbstractThis article reports a high‐performance rechargeable battery enabled by an electrospun quasi‐solid‐state electrolyte (E‐QSSE). The E‐QSSE, composed of Poly(vinylidene fluoride‐co‐hexafluoropropylene) (PVDF‐HFP), Mg(NO3)2 salt, and Pyr14TFSI ionic liquid (IL), exhibits high Mg2+ ion transport and interfacial stability. A unique sandwich structure coupling the E‐QSSE with a Ruthenium nanoparticles decorated multi‐walled carbon nanotubes (Ru/CNT) cathode catalyst on carbon paper significantly augments electrochemical reversibility. The optimized E‐QSSE with a 1:1 molar ratio of salt and IL achieves a high room temperature ionic conductivity of 6.39 mS cm−1. The E‐QSSE's electrochemical stability window extends up to 3.95 V, showcasing its potential for high‐energy‐density applications. The Mg‐O2 cell, with the optimized E‐QSSE, delivers 115 discharge/charge cycles at 100 mA g−1, one of the longest reported cycle‐lives for secondary Mg‐O2 batteries. The battery exhibits a maximum discharge capacity of 9305 mAh g−1 with 100% Coulombic efficiency. X‐ray photoelectron spectroscopy and absorption near‐edge structure analyses reveal MgO as the primary discharge product, with MgF2 contributing to stable solid electrolyte interphase. This E‐QSSE design promotes efficient Mg2+ ion migration and stable electrochemical reactions. This work advances the development of stable, high‐capacity Mg‐O2 batteries and can open up avenues for quasi‐solid‐state electrolytes in post‐lithium metal‐air battery technologies.
Comprehensive Study on Synthesis, Quantum Chemical Calculations, Molecular Modeling Studies, and Cytotoxic Activities of Metal(II) Schiff Base Complexes
Authors: Sogukomerogullari Hatice Gamze , Dede Bülent , Sahin Dicle , Akkoç Senem 
Published: February 2025

ABSTRACTIn this study, mononuclear Ni(II), Cu(II), Zn(II), and Pd(II) complexes of a diimine molecule (H2L) were synthesized, and their structures were elucidated by NMR, FT‐IR, UV–Vis, ICP‐OES, molar conductivity, magnetic susceptibility, and elemental analysis techniques. Stoichiometric and spectroscopic data revealed that the complexes have a metal:ligand ratio of 1:1 and the Schiff base coordinates with the metal(II) ion via nitrogen atoms of two imine groups and oxygen anions of two phenolate moieties and have a square planar geometry. The cytotoxic activity properties of the ligand and its metal complexes were screened in two distinct cancer cell lines: lung (A549) and colon (DLD‐1). The optimized molecular geometries, molecular electrostatic potential diagrams, total density of states plots, and frontier molecular orbitals of the H2L ligand and all metal(II) complexes at the ground level were calculated using density functional theory. The LANL2DZ basis set containing the effective core potentials for transition metals was used for quantum chemical calculations. The calculations supported the square planar geometry of the metal(II) ions in the complexes. The potential of all molecules to inhibit the MLK4 kinase domain (PDB ID: 4UYA) involved in cancer progression was examined by molecular docking study and the best inhibition activity belonged to the H2L molecule with a binding energy of −10.8 kcal/mol. The stability of the H2L–4UYA complex in physiological media was also confirmed by molecular dynamics simulation for 100 ns.
Aldh1l1‐Cre/ERT2 Drives Flox‐Mediated Recombination in Peripheral and CNS Infiltrating Immune Cells in Addition to Astrocytes During CNS Autoimmune Disease
Authors: Amatruda Mario , Turati Juan , Weiss Josh , Villavicencio Jorge , Chen Zhihong , Britton Graham , Horng Sam 
Published: February 2025

ABSTRACTIntroductionThe transgenic murine Cre/loxP system is deployed to investigate the role of central nervous system (CNS) cell‐specific gene alterations in both healthy conditions and models of neurologic disease. The Aldh1l1‐Cre/ERT2 line is widely used to target astrocytes with high coverage and specificity within the CNS. Specificity outside the CNS, however, has not been well‐characterized, and Aldh1l1‐Cre/ERT2‐mediated recombination within the spleen has been reported. In many CNS diseases, infiltrating immune cells from the periphery drive or regulate pathogenesis. We tested whether flox‐mediated recombination from Aldh1l1‐Cre/ERT2 occurs in immune cells in addition to astrocytes and whether these cells traffic from the spleen into the spinal cord during experimental autoimmune encephalomyelitis (EAE), a model of CNS autoimmune disease.MethodsTwo astrocyte‐targeted mouse lines were generated with the red fluorescent reporter, tdTomato, by crossing the Cre‐recombinase lines, Tg(Aldh1l1‐Cre/ERT2)1Khakh and Tg(Gfap‐Cre)73.12Mvs, with the reporter line, Gt(ROSA)26Sor. Aldh1l1‐Cre/ERT2 was activated with 5 days of intraperitoneal tamoxifen, whereas Gfap‐Cre was constitutively active. EAE was induced 2 weeks after tamoxifen, and then spleens and spinal cords were harvested and processed for flow cytometry at various time points after disease onset in EAE versus healthy controls.ResultsIn EAE, Aldh1l1‐Cre/ERT2, but not Gfap‐Cre, induced multiple tdTomato+ immune cell subpopulations in the spleen and spinal cord, including macrophages, monocytes, neutrophils, eosinophils, B cells, CD4+, and CD8+ T cells.ConclusionUse of Aldh1l1‐Cre/ERT2 should therefore account for recombination in both astrocytes and immune cells in disease models involving peripheral immune cell infiltration into the CNS.
Adolescent Depression and Cognition Risk for Suicide: An Investigation of Risk Factors and Gene Environment Interactions
Authors: Pilkay Stefanie , Halevy Devorah , Femia Danielle , Holland Sage Malina , Heiland Stephanie , Carroll Andrew M , Nunes Sarah , Veerman Tara , Dudak Leah 
Published: February 2025

ABSTRACTBackgroundPrior research has been conducted to understand the connection between maternal physical health and its effects on children and adolescents. Much less research has focused on maternal mental health and gene‐environmental factors that influence children's and adolescent's development. This study investigated the risk factors and gene‐environment interactions in relation to maternal mental health and adolescent depression and cognition risk for suicide.MethodsThe data and sample utilized in this research were obtained from The Future of Families and Child Wellbeing Study. The cohort comprises a total of 4898 children and their corresponding caregivers, of which 1829 had complete data and were used in this study. To account for missing data, the list wise deletion approach was employed for all analyses. The variables were tested using Likert scales and/or other similar scales designed to specifically measure the variable. Hypotheses were tested with multiple regressions and bootstrapping. Multiple comparisons were controlled with the Benjamini Hochberg false discovery approach, and BH adjusted p‐values are reported with each statistically significant result.ResultsThe analyses revealed four significant relationships: (1) poverty status is a strong predictor of adolescent mental health, (2) toddler attachment is affected by maternal mental health but does not interact with maternal mental health to predict adolescent mental health, (3) maternal mental health affects suspected childhood sexual abuse associations with adolescent mental health, and (4) serotonin transporter alleles (SLC6A4) exert specific effects on adolescent mental health cognitions previously linked to suicide risk.ConclusionIn summary, this study concludes that the experiential factors and genetic variation have interconnected influences on the mental well‐being of children and adolescents. Therefore, interventions aimed at addressing child trauma would be enhanced by integrating a component that specifically addresses the mental well‐being of mothers.
Dietary Magnesium Intake Is Associated With Self‐Reported Short Sleep Duration but Not Self‐Reported Sleep Disorder
Authors: Zhao Shuhua , Hu Jingping , Yue Chuannan , Tian Jingling , Zhou Shaoli , Zhu Qianqian 
Published: February 2025

ABSTRACTBackgroundSleep disturbances have become increasingly prevalent in modern society. Research suggests that a deficiency in magnesium (Mg) may contribute to sleep disturbances. This study aims to investigate the association between daily Mg intake and self‐reported sleep duration and sleep disorders using data from the National Health and Nutrition Examination Survey (NHANES).MethodsThe study dataset includes participants from five cycles (2009–2018) of NHANES. The associations between Mg intake and sleep duration are analyzed using weighted logistic regression.ResultsBaseline characteristics of 21,840 participants were analyzed. Mg intake was independently associated with sleep duration (OR = 1.07, 95% CI (1.01–1.14), p = 0.024). Higher quartiles of Mg intake from food were associated with normal sleep duration. However, Mg intake from food in participants with self‐reported sleep disorders did not differ from those without sleep disorders (OR = 0.96, 95% CI (0.90–1.03), p = 0.238). Among 3923 participants with Mg supplementation data, no significant differences were found between the top and bottom 50% Mg supplementary groups regarding sleep duration or disorders.ConclusionsDietary Mg intake is independently associated with self‐reported short sleep duration but not with self‐reported sleep disorders. Mg supplementation is not associated with either self‐reported sleep duration or sleep disorders.
Vitamin C and Gallic Acid Ameliorate Motor Dysfunction, Cognitive Deficits, and Brain Oxidative Stress in a Valproic Acid‐Induced Model of Autism
Authors: Tarahomi Parnia , Arab Mina , Seyedinia Seyed Ali , Rahmani Mehrnoush , Rashidy‐Pour Ali , Vafaei Abbas Ali , Raise‐Abdullahi Payman 
Published: February 2025

ABSTRACTPurposeAutism, a developmental‐neurodegenerative disorder, often manifests as social communication difficulties and has been correlated to oxidative stress in the brain. Vitamins C and gallic acid (GA) possess potent antioxidant properties, making them potential candidates for addressing autism‐related issues. This study examined the influence of vitamin C (Vit C) and GA on behavioral, motor, and cognitive performance, along with the assessment of brain oxidative markers, using an experimental model of autism.MethodFourteen female rats were divided into saline and valproic acid (VPA) groups, and mating with mature male rats generated offspring. VPA (500 mg/kg) was injected intraperitoneally (i.p.) on gestational day (GD) 12.5. Male pups remained undisturbed for 29 days. On postnatal day (PND) 30, 48 male pups were randomly selected and administered daily injections of Vit C (30 mg/kg, i.p.) or GA (30 mg/kg, i.p.) for 4 weeks (PND 38–65). Behavioral assessments were conducted before and after treatment (PND 30–37 and 66–73). Animals were then anesthetized, and their brains were analyzed for oxidative stress markers.FindingThe prenatal VPA‐induced autism model increased nociceptive threshold, heightened anxiety‐like behaviors, impaired balance power, delayed spatial learning, elevated malondialdehyde, and decreased glutathione and catalase levels in the brains of the male offspring. Administration of Vit C and GA effectively mitigated these anomalies.ConclusionsVit C and GA could potentially alleviate anxiety‐like behaviors, motor and cognitive deficits, and brain oxidative stress markers in a prenatal rat autism model. This underscores their viability as potential pharmacological interventions for treating autistic dysfunction.
Eco‐Innovation, Corporate Governance and Nation‐Level Institutions: A Cross‐Country Evidence
Authors: Roy Arup , DasGupta Ranjan 
Published: February 2025

ABSTRACTThere is a dearth of empirical research to examine how a firm's internal corporate governance mechanisms would impact eco‐innovation practices under distinctive nation‐level institutions. Therefore, we conducted this study to examine the individual roles of board size, board diversity (i.e., female directors' presence) and board independence in motivating a firm's eco‐innovation practices in an extended cross‐country setting. Furthermore, we examine whether nation‐level institutions moderate our primary study associations. By employing the system generalized method of moment (SGMM) method for panel data of 19 countries from 2010 to 2021, we find a positive impact of board diversity and independence, whereas board size has a significant negative influence on a firm's eco‐innovation practices. However, the political and cultural systems moderate negatively, whereas the education and labour systems and financial systems strengthen our primary findings. The results remain strong even after using additional measurements for dependent variables, addressing endogeneity concerns and using multiple estimating methods to account for bias from omitted variables. Regulators and policymakers can use these findings to formulate stringent institutional policies in regard to nation‐level eco‐innovation.
Efficient fermentative production of lactodifucotetraose by controlling sequential glycosyltransferase reactions in Escherichia coli
Authors: Moriyama Shu , Sugita Tomotoshi , Yamashita Makoto 
Published: February 2025

AbstractLactodifucotetraose (LDFT) is a human milk oligosaccharide (HMO) that might reduce inflammation in infants. In this study, we established a useful production process of LDFT by engineering two key enzymes, α1,2‐fucosyltransferase (α1,2‐FucT) and α1,3‐fucosyltransferase (α1,3‐FucT). First, we verified which of 2′‐fucosyllactose (2′‐FL) or 3‐fucosyllactose (3‐FL) (mostly unverified) was more useful. We searched for FucTs that functioned efficiently in vivo against the raw material lactose or the two intermediates 2′‐FL or 3‐FL by external substrate addition to culture medium. We found that α1,2‐ FucT (HMFT) from Helicobacter mustelae and the N‐terminal truncated form of α1,3‐FucT from Bacteroides fragilis (BfFucTΔN10) had high potential. 3‐FL was not efficiently converted to LDFT, which might be attributed to the low reactivity of HMFT to 3‐FL as well as the low uptake efficiency of 3‐FL by LacY, as revealed by a growth test with exogenously added FL as the sole carbon source and heterologously expressed intracellular fucosidase. Furthermore, because 3‐FL accumulation had a negative impact on cell growth, we avoided the route passing through 3‐FL. By adjusting the copy numbers of HMFT and BffucTΔN10, we produced LDFT from lactose predominantly via 2′‐FL. Finally, 17.5 g/L of LDFT (with 6.8 g/L 2′‐FL and no 3‐FL or residual lactose) accumulated in a 3‐L fed‐batch culture after 77 h. This study reports the detailed analysis of multiple pathways and shows the control of glycosyltransferases can improve the production efficiency of complex HMOs.
How Come They Know? The Effects of Social Comparison on Value Consciousness and Price Mavenism
Authors: Pillai Kishore Gopalakrishna , Jha Shweta , Sharma Piyush , Chakraborty Ratula , Dobson Paul 
Published: February 2025

ABSTRACTSocial interactions and the exchange of interpersonal information are important to consumers' shopping experiences. Social interactions can trigger social comparisons that can influence consumer's value and price perceptions. This research investigates the effects of social comparison orientation (SCO) on consumers' value consciousness (VC) and price mavenism (PM). It also examines the moderating role of general self‐efficacy (GSE) and identification. We employed a mixed‐method approach and investigated the conceptual framework using a survey (N = 229) and an experimental (N = 516) method. The findings revealed the positive effects of SCO on VC and PM. GSE negatively moderates the impact of SCO on VC. Further, when identification with the social referent is high (vs. low) and assimilation (vs. contrast) effect is observed then upward (vs. downward) comparison leads to greater levels of VC and PM. The paper concludes with implications for marketing value‐focused brands and retailers.
Cyclization of Short Peptides Designed from Late Embryogenesis Abundant Protein to Improve Stability and Functionality
Authors: Wu Yinghan , Ikeno Shinya 
Published: February 2025

AbstractLEA peptides, which are designed based on late embryogenic abundant (LEA) protein sequences, have demonstrated chaperone‐like functions, such as improving drought stress tolerance of Escherichia coli (E. coli). Previous studies have focused on the biological functions of linear LEA peptides. However, the function of cyclic LEA peptide still unknown. This study aimed to explore the cyclic LEA peptides’ bio function like enhance the drought stress tolerance of E. coli by cyclizing the LEA peptide using SICLOPPS (Split Intein Circular Ligation of Peptides and Proteins). The results indicated that cyclization significantly improved the function and extended the potential applications. At the same time, we found that peptides containing numerous lysine residues exhibited reduced performance, which may be due to the exteins’ residues affecting the SICLOPPS efficiency.
Role of the calcium‐sensing receptor in regulating vascular function
Authors: Albert Anthony P. , Greenberg Harry Z.E. 
Published: February 2025

AbstractFunctional expression of the calcium‐sensing receptor (CaSR) in calcitropic tissues, for example, parathyroid glands and kidneys, is important for maintaining Ca2+ homeostasis. It is also established that the CaSR is present in tissues previously thought to be noncalcitropic and this review discusses the role of the CaSR in vascular function, focusing mainly on contractility but also outlining its role in cell proliferation and calcification. Stimulation of the CaSR by extracellular Ca2+ concentration ([Ca2+]o) on perivascular sensory nerves and vascular endothelial cells is associated with vasodilatation through the release of vasoactive substances and stimulation of IKCa channels and nitric oxide synthesis, respectively, which mediate endothelium‐derived hyperpolarizations and activation of BKCa channels and KATP channels in vascular smooth muscle cells (VSMCs). CaSR‐induced vasoconstrictions are mediated by the CaSR expressed in VSMCs, which are coupled to the Gq/11 protein‐coupled pathway. In addition, the CaSR expressed on VSMCs also regulates proliferation and calcification. Consequently, the CaSR has been implicated in regulating systemic and pulmonary blood pressure and calcimimetics and calcilytics are potential therapeutic targets for cardiovascular diseases, such as hypertension, pulmonary artery hypertension, and atherosclerosis.
Insights into the Role of the D‐Cluster in [NiFe]‐CODH from Rhodospirillum Rubrum
Authors: Contaldo Umberto , Guigliarelli Bruno , Perard Julien , Pichon Thomas , Le Goff Alan , Cavazza Christine 
Published: February 2025

AbstractThe [NiFe]‐CODH from Rhodospirillum rubrum contains [4Fe4S] clusters that allow electron transfer from the buried active sites to the protein surface. Among them, the role of the D‐cluster, located at the dimer interface is still not fully understood. In this study, the removal of the D‐cluster by site‐directed mutagenesis revealed remarkable features in the behavior of the enzyme. Quantitative analysis and spectroscopic studies unveiled the suppression of D‐cluster in the mutants and the influence on other metal cofactors. Furthermore, the CO oxidation activity in solution measured in the presence of methylviologen is almost completely abolished in the mutants. Conversely, direct electrochemistry at a functionalized carbon nanotube electrode shows that the mutants are still catalytically active reaching reduced but significant current densities of 0.7 mA cm−2. Moreover, the electroenzymatic activity towards oxygen is not affected by the removal of the D cluster. EPR studies reveal a remarkable change in the magnetic coupling between FeS clusters upon removal of the D‐cluster, highlighting the effect of the location of this D‐cluster at the dimer interface. It is noteworthy that in addition to its role as electron relay, the D‐cluster appears to play an important role in the biosynthesis of the active site.
COBALT DOPED IRON BASED PEROVSKITE CATALYSTS FOR EFFICIENT REDUCTION OF NITRATE TO AMMONIA
Authors: Syoum Wahid Meles , Zhang Kai , Wang Yasen , Peng Hongbo , Guo Haoran , Chen Jun Song , Li Tingshuai 
Published: February 2025

Electrochemical nitrate reduction reaction (NO3RR) has received universal attention to synthesize value‐added ammonia, which requires high‐efficiency catalysts to reduce the reaction barrier. Herein, cobalt doped SrFeO3 nanofibers (SCFO) with abundant oxygen vacancies via electrospinning technique is proposed to convert nitrate to ammonia. Such catalyst achieves an optimum Faradaic efficiency of 81.5% and a high NH₃ yield of 16.1 mg h⁻¹ mg‐1cat. in a 0.1 M PBS + 0.1 M NaNO₃ solution at ‐0.9 V reversible hydrogen electrode (RHE). Moreover, the in‐situ electrochemical test and DFT calculations confirm the potential‐determining step (PDS) for SCFO is *NO‐*N with an energy barrier of only 1.28 eV.
A First Principle Study to Understand the Importance of Edge‐exposed and Basal Plane Defective MoS2 Towards Nitrogen Reduction Reaction
Authors: Xiao Yuan-Hui , Wu Xin-Wei , Chen Lai-Ke , Ma Zi-Wei , Lin Jian-De , Rajkumar Devasenathipathy , Wu De-Yin , Tian Zhong-Qun , Devasenathipathy Rajkumar 
Published: February 2025

Nitrogen reduction reaction (NRR) as a promising approach to ammonia synthesis has received much attention in recent years. Herein, by using density functional theory (DFT) calculations, we constructed edge‐exposed MoS2 and different kinds of basal plane defects, including anti‐site, sulfur vacancy and pore defects, to systematically investigate their influence on the NRR performance. The thermodynamically calculated results revealed that the NRR on edge‐exposed MoS2, anti‐site defects, sulfur vacancy with three sulfur atoms missing (S3V) and porous defect (D) exhibit great catalytic activity with low limiting potentials. The calculated limiting potentials are ‐0.43 and ‐0.47 V at armchair and zigzag edge MoS2, ‐0.42 and ‐0.44 V at anti‐site defects, ‐0.49 and ‐0.67 V at S3V and D. However, by inspecting the thermodynamic properties of the hydrogen evolution reaction, we proposed that the zigzag‐end MoS2 and anti‐site defects exhibit a better NRR selectivity compared to armchair‐end MoS2, S3V and D. Electronic structure calculations reveals that the edge‐exposed and basal plane defective MoS2 can improve the conductivity of the material by reducing the band gap. Donation‐backdonation mechanism can effectively promote the activation of nitrogen molecule.