bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coronary cardiovascular Disease and the Treatment of Atherosclerosis A REVIEW
Authors: Bharatia Rakesh , Kumar Shailendra , Jaiswal Abhishek , Jaiswal Hariom 
Published: March 2024

Coronary cardiovascular disease could be a disorder of the center sometimes causeby a condition known as induration of the arteries. induration of the arteries is one among the main and most frequent causes of Heart arrest. illness|arteriosclerosis|arterial sclerosis|hardening of the arteries|induration of the arteries|coronary-artery disease} is that the disease that affects the massive arteries and it's the condition during which development of plaque happens within these arteries. This causes the narrowing of arteries. Plaque is created of fatty substances, cholesterin, cellular waste product, metallic element and protein (a natural process material within the blood). medicine studies have exhibited many vital risk factors related to induration of the arteries. induration of the arteries} plaque among the coronary arteries is chargeable for arteria coronaria disease, heart muscle misdemeanour and Acute coronary syndromes. Induration of the arteries will cause serious issues, together with heart failure, stroke, or maybe death. This study in the main discusses the mechanism of development of induration of the arteries within the arteries, their risk issue and also the recent advancements to treat the induration of the arteries
To determine drug interactions between the medicines given to Dengue Patients
Authors: Sharma Babita , Sharma Prashant Kumar , Gupta Prasang 
Published: March 2024

Dengue fever is a viral disease transmitted by infected mosquitoes, primarily Aedes aegypti and Aedes albopictus. Symptoms include fever, headache, joint and muscle pain, nausea, vomiting, and a rash. In severe cases, it can lead to complications such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), which can be fatal. The pathogenesis of dengue is a complex process involving viral replication, an immune response, and the potential for excessive inflammation and plasma leakage. Understanding the pathogenesis of dengue is crucial for the development of effective prevention and treatment strategies. Dengue virus is further divided into four distinct serotypes, known as DENV-1, DENV-2, DENV-3, and DENV-4, and infection with one serotype does not provide immunity against the other serotypes. There are currently no vaccines that can protect against all four serotypes of DENV.
Sphingosomes: A Novel Vesicular Drug Delivery System
Authors: Bharatia Rakesh , Kumar Shailendra , Chaursiya Swarnima , Gautam Kundan Mishra , Bharti Sheetal , Varun Rajani 
Published: March 2024

Sphingosomes are bilayer vesicles, primarily made of natural or synthetic sphingolipids, that completely surround an aqueous volume. Sphingosomes address the main issues with vesicle systems (liposomes, niosomes), including their lack of stability, short in vivo circulation times, and poor tumour loading efficacy in cancer therapy. Sphingosomes are a promising vesicular drug delivery system that can transport therapeutic chemicals for a variety of potential applications, according to the review's findings. The development of novel medication delivery systems has received a lot of attention in recent decades (NDDS). To begin, it should administer the medication at a pace determined by the body's requirements throughout the course of therapy. Second, it must direct the active entity to the action location. None of these can be met by conventional-dose forms, including extended-release dosage forms. No existing drug delivery system now acts optimally, although genuine efforts have been made to accomplish them via different new drug delivery methods.1-5
Knowledge, Attitude and Practice Regarding Scabies Among Pharmacy Students
Authors: Kumar Selva , Shanmugarajan T S 
Published: March 2024

Scabies is a skin condition caused by infestation with the Sarcoptes scabies mite. This condition is highly contagious and easily spreads through close physical contact. Scabies affects individuals of all ages, races, and socioeconomic statuses. Typically, symptoms of scabies appear two to six weeks after infestation. The most common symptom is itching, which tends to worsen at night. This itching is usually accompanied by a rash that presents as raised, red, scaly spots, and in some cases, blisters.From the collected responses, it was observed that the students displayed a degree of uncertainty regarding the treatment of the disease. In light of this, the study suggests that additional continuous medical education activities could be beneficial. Organizing camps in hostels, conferences, and field visits are proposed as effective methods to enhance the understanding and knowledgeofpharmacystudents in managing scabies cases. This is an online cross-sectional study. The study was conducted over a six-month period. A comprehensive questionnaire-based review was conducted and the data were coded and recorded in an MS Excel spreadsheet to facilitate data analysis. The results of the study indicate that the knowledge, attitude, and practices of pharmacy students regarding scabies were generally good.
Solubility Enhancement of Poorly Water-Soluble Drugs by Solid Dispersion Techniques
Authors: Gupta Vishal , Kumar Sokindra , Agrawal Rajesh 
Published: March 2024

The fact that newly discovered API’s (about 90%) or new molecular entity (NME) have little or poor aqueous solubility, causes a significant challenges to the initialization of development and commercialization of dosage form at the manufacturing facility. Poor aqueous solubility of API’s has critical role in drug dissolution or availability of drug at the site of actionor bioavailability, when a dosage form is administered orally. Various techniques are available for the enhancement of solubility but all individual techniques have its own limitations for commercialization. The known Solubility enhancement techniques like Solid dispersions involved the dispersion of poorly soluble drug in a suitable inert carrier at a molecular level and form amorphous and highly soluble compounds. The conversion of compound in to amorphous form or reduction of particle size to its molecular level caused enhanced solubility of poorly soluble by the application of solid dispersion techniques.
Pharmacy Exit Exam for the Upliftment of Profession of Pharmacy Practice in India: A Review
Authors: Khan Hashim , Sebu  , Gaur Praveen , Kumar Arun , Rahman Mujib ur 
Published: March 2024

The goal of implementing exit exams for Diploma in Pharmacy (D. Pharm holder) is to encourage students to put effort into their learning. Considering the growth of the healthcare sector in India, pharmacists have a lot of career opportunities if they can cope with the ever-increasing demand for innovation, research, skills, knowledge and talent required in the profession. The pharmacy profession is moving dynamically as we are heading towards becoming the pharmacy of the world. Exit exams can be a good quality indicator for academic program reviews and for educational institutes teaching standards. The compulsion of the exit exam will set into place new standards intended to increase the learning of all students. Such exams result in positive effects on student achievement. Exit exams will surely upgrade the pharmacy profession in India.
Preparation and Characterization of an Antiviral Gel
Authors: Tayal Shivam , Tiwari Pradyumn , Sahu Vinod , Sharma Shivang 
Published: March 2024

The study was to develop an antiviral gel for topical application. The topical application of drug has many advantages over the intravenous and oral administration. It prevents metabolism of drug from liver and avoid the risk of gastrointestinal disorder and inconvenience of intravenous therapy pain. When the drug is applied topically it can penetrate deeper into the skin hence show better absorption and bioavailability. The wide varieties of pharmaceutical dosage form are available for topical drug delivery system. The most used one is gel, ointment and cream. Herpes Simplex Virus (HSV) is widely spread that cause infections. There are two types of this virus, one is HSV-1 usually causes sore around the lip or inside the mouth that are sometime called fever blisters or cold sore and the second is HSV-2, it causes sore on the genitals. Acyclovir is a selective and effective antiviral agent. Acyclovir remains the gold standard in the treatment of Herpes Simplex Virus infections, mainly due to emerging new drug delivery systems which are improving the bioavailability and fewer side effects. The gel was prepared in different batches or formulation by using different types of polymers in varying concentration viz. Carbopol-934, Carbopol-940, HPMC, and Na The gel formulations were evaluated for physical and chemical characterization like visual appearance, drug content, pH, viscosity, extrudability, spread ability etc. and the results was compared.
In-vitro Antidiabetic Activity of Xanthium strumarium L. Leaves
Authors: Shipra  , Kumar Vineet , Kumar Anil , Singh Bhanoo Pratap , Sharma Akanksha 
Published: March 2024

Diabetes mellitus has become a major public health and economic problem across the globe. The inadequacies, as well as serious adverse effects associated with conventional medicines, led to a determined search for alternative natural therapeutic agents. This study aimed to evaluate the in-vitro antidiabetic effects of Xanthium Strumarium L. Leaves Extracts. The % yield of acetone and ethyl acetate extract was found to be 1.9% and 2.5% respectively. Qualitative phytochemical tests confirmed the presence of alkaloids, glycosides, saponins, fats and oils, and phenols in acetone extract while alkaloids, glycosides, glycosides, saponins, steroids and phenols were present in ethyl acetate extract. The in-vitro antidiabetic and antioxidant studies of the extract revealed that the ethyl acetate extract of Xanthium strumarium L. leaves showed good antidiabetic and antioxidant potential when compared with acetone extract and significant with standard compound Acarbose.
A prospective study on the prescription pattern of Antibiotics and oral hypoglycemic drugs among Hospitalized patients with diabetic foot ulcers
Authors: Neena Kirubakaran E M , Selva Kumar k , Rishi Raaj K , Yogavigneshwaran C P 
Published: March 2024

Diabetic foot complications encompass neuropathy, ischemia, and infection-induced tissue breakdown. Individuals with diabetes carry a 20% high susceptibility to foot ulcers due to neuropathy. These ulcers, from peripheral neuropathy or arterial disease in diabetes mellitus (DM) patients, can lead to necrosis and gangrene. Importantly wound healing stands as the primary goal in treating diabetic foot ulcers (DFUs), with meticulous glucose control and suitable antibiotic administration.
“Liposomes - An Updated overview”
Authors: Sakshi  , Singh Ranjan Kumar 
Published: March 2024

Due to their great biocompatibility, biodegradability, and minimal immunogenicity, liposomes are now the most widely employed nanocarriers for a variety of hydrophobic and hydrophilic compounds that may be biologically active. Additionally, liposomes demonstrated improved drug solubility and regulated distribution. They also showed the ability to modify the surface of drugs for targeted, extended, and sustained release. Liposomes can be thought of as having developed from traditional, long-circulating, targeted, and immunological liposomes to stimuli-responsive and actively targeted liposomes based on their composition. More liposomes have advanced stages in clinical trials, and many liposomal-based drug delivery systems are currently clinically licensed to treat several disorders, including cancer, fungal infections, and viral infections. This review discusses the composition, preparation procedures, and clinical uses of liposomes.
Innovative Vesicular Drug Delivery Systems: Unleashing the Power of Nanocarriers
Authors: Garg Sarita 
Published: March 2024

"Drug delivery systems utilizing vesicular nanocarriers represent a revolutionary approach in modern pharmaceutical science. These innovative systems harness the potential of nanotechnology to enhance therapeutic efficacy, improve drug bioavailability, and mitigate adverse effects. Vesicular nanocarriers, encompassing liposomes, niosomes, ethosomes, and transfersomes among others, exhibit remarkable versatility in encapsulating diverse pharmaceutical agents, ranging from small molecules to biologics. Their unique structural properties and tunable characteristics enable precise modulation of drug release kinetics, facilitating targeted delivery and controlled release at the desired site of action. Moreover, these nanocarriers offer inherent advantages, including increased stability, reduced toxicity, and the potential to overcome biological barriers, thereby revolutionizing the landscape of drug delivery. This abstract explores the state-of-the-art advancements, promising applications, and future prospects of vesicular nanocarriers, shedding light on their transformative role in optimizing therapeutic outcomes and paving the way for personalized medicine."
Hemodynamic aspects of compensatory reactions of human cardiovascular system in conditions of postural loads
Authors: Yukhymenko Liliia , Makarchuk Mykola , Korobeynikov Georgiy , Korobeynikova Lesia , Imas Yevgeniy , Kozina Zhanneta 
Published: March 2024

IntroductionThe aim of the work was to study the features of central hemodynamic reactions and regulatory mechanisms in persons with hypo- and hyperkinetic blood circulation and different physical status under postural loads.MethodsThe parameters of central hemodynamics and spectral characteristics of the heart rhythm were applied. Healthy men aged 18–21 years with different physical status were involved.ResultsSignificant differences were established in adaptive reactions of people with different types of blood circulation and physical status in the conditions of postural loads. Adaptive reactions of central hemodynamics in individuals with the hyperkinetic compared with hypokinetic type of blood circulation in the head-up-tilt position were characterized by more intracardiac and vascular tension and less involvement of the higher vegetative centres. The surveyed persons with the hypokinetic type of blood circulation under these conditions were characterized by lower vascular activation and greater involvement of systemic extracardiac regulation mechanisms. The compensatory reactions of the cardiovascular system in the head-down-tilt position of people with the hypokinetic type of blood circulation, especially athletes, were characterized by a lower activity of the contractile function of the heart and the participation of extracardiac mechanisms of regulation, and those with the hyperkinetic type – by more prominent switching of the higher regulatory centres of the central nervous system and humoral nervous centres on the background of the tension of self-regulation processes.ConclusionsThe revealed features of compensatory reactions of the cardiovascular system may be useful in the field of clinical and sports medicine, and physical rehabilitation.
THE IMPACT OF BIG DATA ON HEALTHCARE PRODUCT DEVELOPMENT: A THEORETICAL AND ANALYTICAL REVIEW
Authors: Damilola Oluwaseun Ogundipe  
Published: March 2024

The intersection of big data and healthcare product development has catalyzed transformative shifts in the industry, revolutionizing how medical solutions are conceptualized, designed, and deployed. This theoretical and analytical review explores the profound impact of big data on healthcare product development, elucidating its implications across various facets of the healthcare landscape. Utilizing big data analytics, healthcare stakeholders can harness vast volumes of structured and unstructured data to derive actionable insights. These insights inform evidence-based decision-making processes, driving innovation in product development pipelines. By analyzing real-time patient data, trends, and treatment outcomes, developers gain invaluable insights into disease progression, treatment efficacy, and patient preferences, thus facilitating the creation of tailored, patient-centric solutions. Moreover, big data analytics play a pivotal role in improving patient outcomes and quality of care. Through predictive analytics and machine learning algorithms, healthcare providers can identify at-risk populations, predict disease outbreaks, and personalize treatment plans. This proactive approach enhances preventive care strategies and minimizes healthcare costs by averting complications and hospital readmissions. However, the integration of big data into healthcare product development is not without challenges. Data privacy and security concerns necessitate robust frameworks to safeguard sensitive patient information. Moreover, regulatory compliance frameworks must evolve to accommodate the complexities of big data analytics while ensuring patient safety and data integrity. Despite these challenges, the potential of big data in healthcare product development is vast. By leveraging big data analytics, stakeholders can bridge gaps in healthcare access and equity, tailor interventions to underserved populations, and optimize resource allocation. In conclusion, this review underscores the transformative impact of big data on healthcare product development. By embracing data-driven approaches, stakeholders can drive innovation, enhance patient outcomes, and navigate the evolving healthcare landscape with agility and efficacy.
Keywords: Big Data, Healthcare Product Development, Innovation, Patient Outcomes, Data Analytics, Regulatory Compliance.
Loss of nitrogen via anaerobic ammonium oxidation (anammox) in the California Current system during the late Quaternary
Authors: van Kemenade Zoë Rebecca , Erdem Zeynep , Hopmans Ellen Christine , Sinninghe Damsté Jaap Smede , Rush Darci 
Published: March 2024

Abstract. The California Current system (CCS) hosts one of the largest oxygen minimum zones (OMZs) in the world: the eastern North Pacific (ENP) OMZ, which is dissociated into subtropical and tropical regions (i.e. the ESTNP and ETNP). In the modern ENP OMZ, bioavailable nitrogen (N) is lost via denitrification and anaerobic ammonium oxidation (anammox). Even so, paleo-reconstructions of N loss have focused solely on denitrification. Fluctuations in bulk sedimentary δ15N over glacial–interglacial cycles have been interpreted to reflect variations in denitrification rates in response to ETNP OMZ intensity changes. This δ15N signal is thought to be transported northwards to the ESTNP OMZ. Here, we present the first CCS sedimentary record of ladderane lipids, biomarkers for anammox, located within the ESTNP OMZ (32° N, 118° W). Over the last two glacial terminations (∼ 160 kyr cal BP), ladderane concentrations were analysed in combination with the index of ladderanes with five cyclobutane moieties (NL5), short-chain (SC) ladderane degradation products, and productivity proxies. This shows that (1) ladderanes were derived from anammox bacteria living within the ESTNP OMZ water column; (2) ladderanes were continuously present, with relatively high concentrations during both glacial and interglacial periods, showcasing that the ESTNP OMZ must have retained an anoxic core in which N loss occurred; and (3) anammox abundance appears to have been driven by both organic matter (OM) remineralization and advection changes, which regulated nutrient and oxygen levels. Our study shows that anammox was an important feature in the CCS, and it provides a more holistic picture of N-loss dynamics and the development of the ESTNP OMZ over glacial–interglacial cycles. Lastly, ladderanes and their SC products were also detected in 160–500 kyr cal BP sediments (15.7–37.5 m b.s.f., metres below sea floor; analysed at a low temporal resolution), highlighting their potential as anammox biomarkers in relatively deeper buried sediments for future studies.
Personal Growth and Psychological Well-Being of Dementia Caregivers
Authors: Ateeq Aisha , Attique Zainab , Huda Noor ul 
Published: March 2024

Dementia is a neurological condition that impacts mental processes such as reasoning or the ability to think. Caregiving for such individuals is a strenuous process that leads to both positive and negative changes in the caregiver’s life. Thus, the purpose of this research was to investigate the correlation between the personal growth and psychological well-being of caregivers. With the aid of pre-existing literature, two hypotheses were formed: (i) there is a positive correlation between personal growth and psychological well-being of a dementia caregiver, (ii) having significant social support positively correlates with improved personal growth and psychological well-being of the caregiver. Using convenient sampling, a sample of 102 participants from Pakistan above the age of 18 was selected, and two scales were administered to the participants. The first scale was ‘the role of caregivers' skills in caregivers' syndrome and caregivers' burden’, which assessed the extent of changes in psychological well-being and personal growth that the severity of dementia within patients had on the patient’s caregiver. The second was the ‘Caregiver Appraisal Scale’ which measured the caregiver’s burden, satisfaction, mastery, demands and the impact experienced by them. No deception was involved, and confidentiality of participants was maintained. Their participation was completely voluntary and their rights as research participants were protected at all times. Results were analyzed using the correlation coefficient. No significant correlation was found for either of the hypotheses. This research aimed to create awareness regarding the significance of being a caregiver and what it entails.
Tacit Knowledge, Audit Quality, and Talent Identification
Authors: Künneke Judith 
Published: March 2024

The auditing literature has recently transitioned from the focus on client- or audit firm-level characteristics and their relation with audit quality to the inclusion of audit partner and team effects in audit quality. We extend this literature by studying whether tacit knowledge is a relevant factor in achieving high audit quality. Using survey measures and unique proprietary data of a Big 4 firm, we find evidence that the engagement partners’ level of tacit knowledge explains variation in audit quality as defined by the firm’s internal assessment of audit quality. Given its value-creating character, we subsequently examine whether tacit knowledge is a criterion that is incorporated in the talent identification process. We find that tacit knowledge is largely ignored or even negatively correlated with the firm’s assessment of potential, which likely provides an explanation for the loss of talent in professional audit firms.Paper available via this [Tresorit link](https://web.tresorit.com/l/4A8ET#z1xFuLOrKx5sc7ovbISJEw).
“Life in death”: Decolonizing Trauma in Sinan Antoon’s The Corpse Washer
Authors: Salam Wael J. , Abu-Shomar Ayman 
Published: March 2024

ABSTRACT
This article examines the poetics of death in the Iraqi American writer Sinan Antoon’s novel The Corpse Washer. The novel depicts death as a leitmotif while emphasizing the perils of wars and violence on the Iraqi people. Throughout the novel, death is omnipresent, looming over the lives of the characters, particularly the protagonist Jawad who endures nightmares, hallucinations, and split personality. These conditions are engendered by prolonged wars and cycles of violence, including the Iran–Iraq War (1980–1988), the Gulf War (1990–1991), and the invasion of Iraq in 2003. In addition to these wars, characters in The Corpse Washer are victimized by foreign sanctions, suicide bombings, sectarianism, and political corruption. In analyzing the tropes of death and violence in The Corpse Washer, this article extends classical trauma theory informed by Western assumptions and championed by Cathy Caruth, Shoshana Felman, Dori Laub, and others. It decolonizes trauma theory by tracing cases of tragedy, violence, and occupation in the global South, an analysis that will render the theory cross-cultural and inclusive of non-Western traumata.