bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and clinical markers of herpes simplex virus infection in oral lesions of bullous pemphigoid
Authors: Zhang Hanmei , Yu Meiwen , Liang Guirong , Li Suo , Zhao Chenjing , Jing Ke , Feng Suying 
Published: April 2024

BackgroundThe manifestations of bullous pemphigoid (BP) and herpes simplex virus (HSV) infection are similar in oral mucosa, and the laboratory detection of HSV has some limitations, making it difficult to identify the HSV infection in oral lesions of BP. In addition, the treatments for BP and HSV infection have contradictory aspects. Thus, it is important to identify the HSV infection in BP patients in time.ObjectiveTo identify the prevalence and clinical markers of HSV infection in oral lesions of BP.MethodsThis prospective cross-sectional descriptive analytical study was conducted on 42 BP patients with oral lesions. A total of 32 BP patients without oral lesions and 41 healthy individuals were enrolled as control groups. Polymerase chain reaction was used to detect HSV. Clinical and laboratory characteristics of patients with HSV infection were compared with those without infection.ResultsA total of 19 (45.2%) BP patients with oral lesions, none (0.0%) BP patients without oral lesions, and four (9.8%) healthy individuals were positive for HSV on oral mucosa. Among BP patients with oral lesions, the inconsistent activity between oral and skin lesions (p=0.001), absence of blister/blood blister in oral lesions (p=0.020), and pain for oral lesions (p=0.014) were more often seen in HSV-positive than HSV-negative BP patients; the dosage of glucocorticoid (p=0.023) and the accumulated glucocorticoid dosage in the last 2 weeks (2-week AGC dosage) (p=0.018) were higher in HSV-positive BP patients. Combining the above five variables as test variable, the AUC was 0.898 (p&lt;0.001) with HSV infection as state variable in ROC analysis. The absence of blister/blood blister in oral lesions (p=0.030) and pain for oral lesions (p=0.038) were found to be independent predictors of HSV infection in multivariable analysis. A total of 14 (73.7%) HSV-positive BP patients were treated with 2-week famciclovir and the oral mucosa BPDAI scores significantly decreased (p&lt;0.001).ConclusionHSV infection is common in BP oral lesions. The inconsistent activity between oral and skin lesions, absence of blister in oral lesions, pain for oral lesions, higher currently used glucocorticoid dosage, and higher 2-week AGC dosage in BP patients should alert physicians to HSV infection in oral lesions and treat them with 2-week famciclovir in time.
Effectiveness of the acute stroke care map program in reducing in-hospital delay for acute ischemic stroke in a Chinese urban area: an interrupted time series analysis
Authors: Wen Rui , Wang Miaoran , Bian Wei , Zhu Haoyue , Xiao Ying , Zeng Jing , He Qian , Wang Yu , Liu Xiaoqing , Shi Yangdi , Hong Zhe , Xu Bing 
Published: April 2024

BackgroundTimely intravenous thrombolysis (IVT) is crucial for improving outcomes in acute ischemic stroke (AIS) patients. This study evaluates the effectiveness of the Acute Stroke Care Map (ASCaM) initiative in Shenyang, aimed at reducing door-to-needle times (DNT) and thus improving the timeliness of care for AIS patients.MethodsAn retrospective cohort study was conducted from April 2019 to December 2021 in 30 hospitals participating in the ASCaM initiative in Shenyang. The ASCaM bundle included strategies such as EMS prenotification, rapid stroke triage, on-call stroke neurologists, immediate neuroimaging interpretation, and the innovative Pre-hospital Emergency Call and Location Identification feature. An interrupted time series analysis (ITSA) was used to assess the impact of ASCaM on DNT, comparing 9 months pre-intervention with 24 months post-intervention.ResultsData from 9,680 IVT-treated ischemic stroke patients were analyzed, including 2,401 in the pre-intervention phase and 7,279 post-intervention. The ITSA revealed a significant reduction in monthly DNT by −1.12 min and a level change of −5.727 min post-ASCaM implementation.ConclusionThe ASCaM initiative significantly reduced in-hospital delays for AIS patients, demonstrating its effectiveness as a comprehensive stroke care improvement strategy in urban settings. These findings highlight the potential of coordinated care interventions to enhance timely access to reperfusion therapies and overall stroke prognosis.
A contemporary review of breast cancer risk factors and the role of artificial intelligence
Authors: Nicolis Orietta , De Los Angeles Denisse , Taramasco Carla 
Published: April 2024

BackgroundBreast cancer continues to be a significant global health issue, necessitating advancements in prevention and early detection strategies. This review aims to assess and synthesize research conducted from 2020 to the present, focusing on breast cancer risk factors, including genetic, lifestyle, and environmental aspects, as well as the innovative role of artificial intelligence (AI) in prediction and diagnostics.MethodsA comprehensive literature search, covering studies from 2020 to the present, was conducted to evaluate the diversity of breast cancer risk factors and the latest advances in Artificial Intelligence (AI) in this field. The review prioritized high-quality peer-reviewed research articles and meta-analyses.ResultsOur analysis reveals a complex interplay of genetic, lifestyle, and environmental risk factors for breast cancer, with significant variability across different populations. Furthermore, AI has emerged as a promising tool in enhancing the accuracy of breast cancer risk prediction and the personalization of prevention strategies.ConclusionThe review highlights the necessity for personalized breast cancer prevention and detection approaches that account for individual risk factor profiles. It underscores the potential of AI to revolutionize these strategies, offering clear recommendations for future research directions and clinical practice improvements.
The effects of Core Stability Exercises and Mulligan’s mobilization with movement techniques on sacroiliac joint dysfunction
Authors: Yan Huiqian , Zhao Peng , Guo Xuanhui , Zhou Xiao 
Published: April 2024

Purpose:Sacroiliac joint dysfunction (SIJD), while being the primary contributor to low back pain, is still disregarded and treated as low back pain. Mulligan’s Mobilization with Movement (MWM) Techniques and Core Stability Exercises (CSE) are often used to treat low back pain. There is not much evidence that it is effective in SIJD. To evaluate the effectiveness of CSE coupled with MWM (CSE + MWM) in the treatment of SIJD.Methods:39 patients with SIJD were recruited and randomly divided into distinct groups as follows: control group (n = 13), CSE group (n = 13) and CSE + MWM group (n = 13). The Numerical Pain Rating Scale (NPRS), the Roland Morris Disability Questionnaire (RMDQ), the Range of Motion (ROM), the Pressure Pain Threshold (PPT) and the pelvic tilt angle asymmetry ratio in the sagittal plane (PTAR) were used to gauge the intervention’s success both before (M0) and after (M1) it. All experimental data were statistically analyzed.Results:The SIJ-related pain metric significantly decreased in both the CSE + MWM group and the CSE group between M0 and M1, as determined by the NPRS and RMDQ. Between M0 and M1, The CSE group’s left axial rotation ROM and lumbar flexion ROM were significantly decreased. The CSE + MWM group’s extension ROM and left lateral flexion ROM both significantly increased between M0 and M1. In the difference variable (M1-M0), the CSE + MWM group substantially outperformed control group in the left lateral flexion ROM and outperformed the CSE group in the left axial rotation ROM.Conclusion:In individuals with SIJD, CSE + MWM is beneficial in lowering pain, disability, and function. Treatment with CSE and MWM approaches for SIJ appears to boost this efficacy.
Childhood unpredictability and sleep quality in adulthood: the mediating roles of life history strategy and perceived stress
Authors: Qi Wei , He Xiangyang , Wang Zhechen 
Published: April 2024

BackgroundEarly environmental risk have been found to be related to lifelong health. However, the impact of childhood unpredictability, a type of early environmental risk, on health, especially on sleep quality in adulthood, has not been adequately studied. The present study aimed to examine the relationship between childhood unpredictability and sleep quality in adulthood and to explore the possible mediating roles of life history strategy and perceived stress.MethodsA cross-sectional study was conducted on 472 participants from a university in Zhejiang Province, China. The questionnaire inquired about demography, childhood unpredictability, life history strategy (Mini-K), perceived stress (14-item Perceived Stress Scale), and Sleep Quality (Pittsburgh Global Sleep Quality Index).ResultsHigher childhood unpredictability was significantly associated with worse sleep quality in adulthood. Moreover, the link between higher childhood unpredictability and worse sleep quality in adulthood was explained by the chain mediation of life history strategy and perceived stress.ConclusionIn line with the life history theory, individuals who have experienced higher unpredictability in childhood tend to develop a faster life history strategy and become more sensitive to stress in adulthood, and subsequently suffer a decrease in sleep quality.
Preference of primary care patients for home-based healthcare and support services: a discrete choice experiment in China
Authors: Liu Yaqing , Du Sixian , Liu Chaojie , Xue Tianqin , Tang Yuqing 
Published: April 2024

ImportanceThis research, utilizing discrete choice experiments, examines the preferences and willingness to pay for home-based healthcare and support services among residents in China, a country grappling with severe aging population, an area often underexplored in international scholarship.ObjectivesThis study aims to solicit the preferences of primary care patients for home-based healthcare and support services in China.Design, setting, and participantsA discrete choice experiment (DCE) was conducted on 312 primary care patients recruited from 13 community health centers in Wuhan and Kunming between January and May 2023. The experimental choice sets were generated using NGene, covering five attributes: Scope of services, health professionals, institutions, insurance reimbursements, and visiting fees.Main outcomes and measuresThe choice sets were further divided into three blocks, and each participant was asked to complete one block containing 12 choice tasks. Mixed logit models were established to estimate the relevant importance coefficients of and willingness to pay for different choices, while Latent Class Logit (LCL) modeling was conducted to capture possible preferences heterogeneity.ResultsThe relevant importance of the scope of services reached 67.33%, compared with 19.84% for service institutions and 12.42% for health professionals. Overall, respondents preferred physician-led diagnostic and treatment services. LCL categorized the respondents into three groups: Group one (60.20%) was most concerned about the scope of services, prioritizing disease diagnosis and treatment over preventive care and mental health, while group two (16.60%) was most concerned about care providers (hospitals and medical doctors were preferred), and group three (23.20%) was most concerned about financial burdens.ConclusionPrimary care patients prefer physical health and medical interventions for home-based healthcare and support services. However, heterogeneity in preferences is evident, indicating potential disparities in healthcare and support at home services in China.
A population health approach to workplace mental health: rationale, implementation and engagement
Authors: Woodard Kaylee T. , Bailey Allison M. , Esagoff Aaron I. , Fragala Maren S. , Hayward Joanna I. , Hunter Jennifer L. , Hsu Yea-Jen , Kim Paul M. , Peters Matthew E. , Carr Susan M. 
Published: April 2024

ObjectivesTo describe a population health-based program to support employee and dependent mental health and learn from engagement trends.MethodsRetrospective analysis of a program utilizing an assessment of mental health risk. For scoring “at risk,” a Care Concierge is offered to connect users with resources.ResultsParticipation was offered to 56,442 employees and dependents. Eight thousand seven hundred thirty-one completed the assessment (15%). Of those, 4,644 (53%) scored moderate or higher. A total of 418 (9%) engaged the Care Concierge. Factors that negatively influenced the decision to engage care included bodily pain, financial concerns. Positive influences were younger age, high stress, anxiety, PTSD and low social support.ConclusionProactive assessment plus access to a Care Concierge facilitates mental healthcare utilization. Several factors influence likelihood to engage in care. A better understanding of these factors may allow for more targeted outreach and improved engagement.
Retention in Junior Giants, a sport-based youth development program: what factors are associated with intentions to return?
Authors: Bolter Nicole D. , Kipp Lindsay E. , Greenwood P. Brian 
Published: April 2024

IntroductionWhile evaluation research shows that physical activity-based youth development (PA-PYD) programs can have a positive impact on social and emotional growth, less is known about which participants return year after year and what factors are associated with their continued participation. The Junior Giants is a sport-based youth development program for 5–18-year-old boys and girls that is non-competitive and free to participate. The 8-week program uses baseball and softball as platforms for teaching life skills and fostering social emotional competencies. This mixed-methods study evaluated quantitative factors associated with intentions to return to the program the following year and qualitative reasons why parents/caregivers intended not to re-enroll their child.MethodParents/caregivers of Junior Giants participants (N = 8,495) completed online surveys about their child's demographics, social emotional climate and learning, character development, and intentions to return the following year.ResultsDescriptive data illustrated that parents/caregivers reported quite positive outcomes and experiences for their child. Chi-square and t-test analyses revealed significant differences (p &lt; .001) between intended returners (n = 7,179, 84.5%) and those who reported no/undecided on returning (n = 1,316, 15.5%). Intended returners were significantly more likely to be identified as Latino and be in their second year of participation. Significant predictors of a binomial logistic regression [χ2 (df = 22) = 1,463.25, p &lt; .001] included age, race/ethnicity, years played, character development, reading, league experiences, physical activity, and perceived support, with small to medium effect sizes. Using responses from a subset of 217 parents/caregivers who reported their child would not return to the program, a thematic analysis resulted in seven themes: Lack of Organization and Communication; Dissatisfied with Coaching, Didn't Learn Baseball/Softball, Not Competitive Enough, Skill Levels Not Matched, Aged Out, and Non-Program Related Reasons.DiscussionQuantitative results contribute to the literature on predictors of retention in youth development programs, while qualitative findings echo common motives cited for dropout in youth sport. Both provide opportunities for reflection and potential changes to future programming.
Investigating the stretch-shortening cycle fatigue response to a high-intensity stressful phase of training in collegiate men's basketball
Authors: Philipp Nicolas M. , Nijem Ramsey M. , Cabarkapa Dimitrije , Hollwedel Charles M. , Fry Andrew C. 
Published: April 2024

IntroductionWhile using force-plate derived measures of vertical jump performance, reflective of stretch-shortening-cycle (SSC) efficiency is common practice in sport science, there is limited evidence as to which tests and measures may be most sensitive toward neuromuscular fatigue. The aim of this study was to explore the SSC fatigue response to a one-week high-intensity fatiguing phase of training in National Collegiate Athletic Association (NCAA) Division-I basketball players.MethodsThe study timeline consisted of three weeks of baseline measures, one week of high-intensity training, and two weeks of follow-up testing. Countermovement jumps (CMJ) and 10-5 hop tests were performed at baseline, as well as at two time-points during, and three time-points following the fatiguing training period, allowing for performance-comparisons with baseline.ResultsCompared to the weekly training sum at baseline, during the high intensity training phase, athletes were exposed to very large increases in selected external load metrics (ES = 1.44–3.16), suggesting that athletes experienced fatigue acutely, as well as potential longer lasting reductions in performance. Vertical jump data suggested that in the CMJ, traditional metrics such as jump height, as well as metrics reflecting kinetic outputs and movement strategies, were sensitive to the stark increase in high-intensity training exposure. The 10-5 hop test suggested a fatigue-induced loss of tolerance to ground impact reflected by performance reductions in metrics related to jump height and reactive strength qualities.DiscussionThese findings emphasize that when monitoring neuromuscular fatigue, variables and assessments may not be looked at individually, but rather as part of a more global monitoring approach.
Social Support among Mothers with Spouse Postpartum Depression
Authors: Nurhidayati Evi , Dwiarini Muafiqoh , Imamah Nur Fithriyanti 
Published: April 2024

Introduction: Social support is one of the important things that affect factor for postpartum depression. Social support after childbirth is essential to reduce postpartum depression. Support from a spouse reduces psychological disorders among mothers. Objective: This study was to determine the social support among mothers with postpartum depression. Method: This study used a survey design. This research was conducted at Community Health Centers in Yogyakarta with 102 sample postpartum women. The study used the Edinburg Postpartum Depression Scale (EPDS), social support questionnaire, and demographic data questionnaires. The descriptive statistic uses percentage, mean, and standard deviation. Results: The results revealed that the mean score on the EPDS was 15.89 (SD ± 2.47). Generally, postpartum mothers showed moderate postpartum depression. Postpartum mother got high social support from their partner on average for the four subscales were respectively: emotional support 56.9%, household support 52%, babysitting support 51%, and help support 52.9%. Recommendation: Social support has an essential role in minimizing postpartum depression. Strategies to decrease postpartum depression should focus on increasing social support for postpartum mothers. The indicators of postpartum depression should be screened for and closely monitored by healthcare professionals. Additionally, healthcare professionals should provide sufficient assistance that is customized to the mother's needs through her spouse and family
Comparison of Preoperative Pregabalin Versus Dexamethasone for Postoperative Analgesia in Patients Undergoing Inguinal Hernia Repair
Authors: Umer Naseem  , Shah Dr Ammar Ali , Dr Farah Naz  , Awan Muhammad Nazir , Zaheer Jawad 
Published: April 2024

Objective: To compare the efficacy of pregabalin versus dexamethasone for post-operative analgesia in patients undergoing inguinal hernia repair.
This randomized trial was carried out in the Department of Anaesthesia at Holy Family Hospital, Rawalpindi after the approval of the Ethical review board, from February 2019 to November 2019.
Methodology: A total of 120 patients were equally divided into two equal groups using lottery method. Group A received pregabalin and group B received dexamethasone. Patients were observed for 24 hours for post operative pain control. Visual Analogue Scale was used to grade pain at 6, 12 and 24 hours
Results: The mean age in Group-A was 43.38+15.80 years and 42.85+14.52 years in Group-B, comparison of the effect of single dose preoperative Pregabalin and IV dexamethasone on mean post-operative pain in patients undergoing hernia surgery under spinal anesthesia shows that at 6 hrs 2.83+1.10 in Group-A and 3.98+1.41 in Group-B, p value 0.0001, at 12 hrs 2.22+1.28 in Group-A and 3.33+1.49 in Group-B, p value was 0.0001 and at 24 hrs it was calculated as 1.0+0.75 in Group-A and 1.6+1.0 in Group-B, p value was 0.0005.
Conclusion: Pregabalin is superior to dexamethasone for post-operative pain control in patients undergoing hernia repair under spinal anesthesia.
Keywords: Dexamethasone, pregabalin, Inguinal hernia, post-operative pain.
Relationship between Customer Management Micro, Small and Medium Enterprises (MSMEs) and Marketing Performance in Banten
Authors: Suherna Suherna , Nasiatin Titin 
Published: April 2024

Introduction: The current economic crisis in Indonesia, micro, small, and medium-sized enterprises (MSMEs) have proven to be very resilient. When expanding a nation's economy, micro, small, and medium-sized businesses (MSMEs) play a crucial and vital role, so that’s why the researcher want to know about The aim of this research is to see the influence of customer relationship quality on the marketing performance of MSMEs. Materials and Methods: Sampling from food and beverage MSMEs in Banten province. The sample size was 209 respondents. Data collection using a questionnaire with direct interviews with respondents. Secondary data was obtained from BPS Banten Province. analysis technique using the SEM method Results: There is a relationship between Micro, Small and Medium Enterprises (MSME) Customer Management and Marketing Performance with a p value above 0.05.
Pieśń nad Pieśniami na tle powieści greckich
Authors: Wojciechowski Michał 
Published: April 2024

Zauważono już rozmaite analogie między Pieśnią nad Pieśniami a literaturą hellenistyczną. Obejmuje to tematykę miłosną, podobieństwo motywów lirycznych i sielankowych, analogie do dramatów. Przydatne byłoby też porównanie do wcześniejszych powieści hellenistycznych z I wieku, Charitona „Kallirhoe” oraz Ksenofonta „Opowieści efeskich”, z którymi Pieśń mogłaby mieć wspólny wcześniejszy wzór. Byłoby to argumentem za stosunkowo późnym datowaniem Pieśni, może około I wieku przed Chr. Mimo pewnych różnic (forma poetycka, brak przygodowej akcji i przemocy w Pieśni nad Pieśniami oraz ważnej w powieściach warstwy religijnej), zauważyć też można zespół podobieństw. Tu i tam w centrum stoi zakochana para, uroda obojga jest wyjątkowa, miłość napotyka na przeszkody i zagrażają jej rywale, kobieta jest w miłości aktywna i samodzielna, podejmuje decyzje paralelnie i symetrycznie do mężczyzny, akcja zmierza do szczęśliwego zakończenia. Drobniejsze analogie to podobieństwo miłości do choroby oraz wysoka cena płacona za kobietę.