bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peran Al-Qur’an Terhadap Problematika Polusi Udara
Authors: Kamal Muchammad Hafish , Nasa Saputra Reno Aditya 
Published: February 2024

Air Pollution as a Serious Challenge: A Quranic Perspective
Air pollution poses a serious challenge faced by large cities, resulting from human activities such as production, motor vehicles, and forest fires. The escalating air pollution becomes a major contributor to climate change and significant health impacts. The Quran, as the primary guide to life in Islamic teachings, provides guidance on human responsibility as stewards of the Earth to care for and preserve the environment.
This research employs a literature study method with a qualitative approach to analyze the Quranic perspective on addressing air pollution problems. The Quran emphasizes the role of humans as stewards with significant responsibilities in safeguarding and nurturing the Earth. Relevant verses highlight prohibitions against harming nature, maintaining harmony between humans and nature, and the importance of environmental preservation.
Based on data analysis, air pollution can be defined as the presence of harmful substances in the air. Despite the negative impacts of air pollution, awareness of environmental conditions is increasing. The Quran guides the Islamic community to act wisely in addressing air pollution issues by referring to relevant verses.
The Quran provides concrete solutions by emphasizing environmental preservation, wise resource usage, and prohibiting greedy behavior. These verses lay the foundation for environmental ethics that can help address air pollution issues. Solutions involve recycling practices, forest development, industrial waste management, the use of renewable energy, clean technology adoption, vehicle emission control, and wise resource usage.
This research underscores the relevance of Quranic teachings in responding to environmental issues, particularly air pollution, and contributes to determining practical steps for environmental sustainability.
Perceived inclusion of Islamic finance: The effects of attitudes, experience, literacy, religiosity, and social influences
Authors: Khamis Fauz Moh’d , Isa Mohamad Yazid Bin , Yusuff Noraini Binti 
Published: February 2024

The existing literature lacks demand-side perception studies on Islamic finance and its determinants, especially in developing markets. This study examines the influences of attitudes towards Islamic finance (ATTIF), financial experience (FE), Islamic financial literacy (IFL), religiosity (RL), and social influences (SI) on the perceived inclusiveness of Islamic finance (PIIF). This study used purposive sampling to obtain 400 questionnaire respondents from Zanzibar, Tanzania. The Smart-PLS (4) was used for analysing the data. We discovered mixed perceptions among the respondents regarding the inclusiveness of Islamic finance. Furthermore, the findings revealed a positive and significant influence of ATTIF, FE, SI, and RL on PIIF. ATTIF mediates the effects of RL and SI. The effect of ATTIF on PIIF is mitigated by IFL. The two most significant factors that determine PIIF are SI and ATTIF. RL was high among respondents but less important in determining PIIF. Islamic financial institutions should design products that fit society’s needs by considering socio-cultural and economic dynamics. These findings have important policy implications for improving the inclusiveness of Islamic financial markets. This study provides new insight into the inclusion of Islamic finance and its determinants.
Affect of Features of a Microorganism Strain on a Scope of Exclusive Rights
Authors: Ivanov F. S. , Nasonova K. V. 
Published: February 2024

Introduction. A launch of larger number of pharmaceutical preparations based on recombinant products and biotechnologies leads to determine a strategy for protection of exclusive rights for subjects implemented into manufacturing process, including strains of microorganism-producers.Aim. To define a possibility and a protection scope of microorganism strain as intellectual property subjects at a step of research, development and launch of pharmaceutical preparations, including biotechnological products.Materials and methods. The materials of the study were available publications in peer-reviewed journals on thematic queries based on keywords of the selected topic, official websites, regulatory legal acts, regulating the procedure for patenting subjects in the Russian Federation and foreign countries.Results and discussion. A brief review of regulatory acts on registration of a strain as an intellectual property subject is presented. It was defined features of a microorganism strain for patenting and for establishing an infringement of patent rights in the territory of Russian and foreign countries. A possible scope of patent rights for strains is indicated.Conclusion. The problems raised upon protecting strains as intellectual property subjects as well as possibilities of strain registration as exclusive right subjects are defined.
Fournier’s gangrene wounds successfully healed with High pbserum enzymes: a case report
Authors: Paris Eugenia , López Berroa Jorge 
Published: February 2024

Fournier’s gangrene is an aggressive form of infective necrotizing fasciitis in the perianal and genital area. In this article we discuss the case of a 75-year-old male patient diagnosed with Fournier’s gangrene with the entire perianal region affected. Surgical washings were performed and debridement with multiple flaps were required for reconstruction. Complications in the suture wounds, cavities, and a seroma were observed after 5 weeks, and they were treated with dressings. Treatment with High pbserum recombinant enzymes was initiated after 3 weeks, to accelerate the closure of the wounds. The granulation tissue was irrigated by drip irrigation once every 3 weeks, ensuring good tissue impregnation. We observed that the epithelialization of the affected areas was achieved after the first week, and in 1 month, most of the wounds healed properly without signs of infection. High pbserum is an enzyme cocktail, composed of higher collagenase concentration, lipase, and liase. This study shows how High pbserum improves and accelerates wound healing in a patient with Fournier’s gangrene. Further investigations are needed to conclude treatment recommendations.
Analisis Pemanfaatan Teknologi Informasi dan Komunikasi (TIK) Digital untuk Pemasaran Ikan Skala Mikro : Systematic Literature Review
Authors: Leonardi Aska , Sjafri Aida Vitayala , Saleh Amiruddin , Fatchiya Ana 
Published: February 2024

Ikan adalah komoditas yang mudah rusak, sehingga dibutuhkan waktu yang cepat untuk sampai ke konsumen. Namun, banyak kendala yang dialami dalam pemasaran ikan skala mikro, semisal akses pasar, hambatan alam termasuk jarak dan waktu tempuh, hambatan kelembagaan termasuk pembatasan hukum untuk masuk, tarif, dan kuota. Kajian ini dilakukan dalam rangka menggambarkan kondisi terkini penelitian-penelitian tentang pemanfaatan TIK digital dalam pemasaran ikan skala mikro sehingga dapat merekomendasikan suatu hasil kajian tentang komunikasi pemasaran digital pada usaha perikanan skala mikro di masa mendatang. Telaah ini menggunakan metode literatur review, dengan menganalisis 22 artikel jurnal berbasis pencarian kata kunci yang relevan. Seluruh artikel kemudian dianalisis, dan dideskripsikan. Hasil menunjukkan bahwa adopsi ponsel terutama dilihat dari perspektif ekonomis, dapat berdampak pada peningkatan efisiensi pasar. Fokus utama yang menjadi peluang untuk menyumbang konsep komunikasi pemasaran ikan skala mikro adalah penelitian mengenai adopsi pemasar ikan skala mikro dalam menggunakan TIK digital.
Graduate certificate on risk analysis for the Agrifood sector at the University of Buenos Aires
Authors: Vicién Carmen , Rubinstein Clara 
Published: February 2024

Argentina has an extensive experience in the biosafety assessment of transgenic crops. The regulatory framework celebrated 30 years of existence in 2021 and has pioneered the establishment of the biosafety systems in Latin America. During this period, Argentina’s regulatory framework evolved to keep up with the advancements in plant and animal biotechnology and in risk assessment criteria, as new knowledge and experience was being gained. However, despite the country’s agricultural tradition and experience in the adoption of innovations by the productive sector, dedicated, formal academic offerings training is lacking and this is also true for most countries in the world. Responding to this perceived need and going beyond biotechnology to include other regulated inputs used along the food production chain (chemicals, biologics, food additives, etc.), we developed a program to introduce graduates from diverse disciplines to the principles and practice of Risk Analysis (Assessment, Management and Communication) with focus on the Agrifood sector. In 2020, the School for Graduate Students of the School of Agriculture—University of Buenos Aires, approved two Certificates on Risk Analysis for the Agrifood Sector: Conceptual Bases of Risk Analysis and Methodological Tools. The first edition of the certificates was completed in December 2022 and the second one is presently ongoing. The fundaments, rationale, structure and objectives of these certificates are presented.
PqsA mutation-mediated enhancement of phage-mediated combat against Pseudomonas aeruginosa
Authors: Su Qiao , Lu Di , Kong Jiuna , Lin Hong , Xuan Guanhua , Wang Jingxue 
Published: February 2024

Phage therapy is a potential approach in the biocontrol of foodborne pathogens. However, the emergence of phage resistance and the narrow host range of most phage isolates continue to limit the antimicrobial efficacy of phages. Here, we investigated the potential of the pqsA gene, encoding the anthranilate-CoA ligase enzyme, as an adjuvant for phage therapy. The knockout of the pqsA gene significantly enhanced the bactericidal effect of phages vB_Pae_QDWS and vB_Pae_S1 against Pseudomonas aeruginosa. Under phage infection pressure, the growth of the PaΔpqsA was significantly inhibited within 8 h compared to the wild-type PAO1. Furthermore, we found that altering phage adsorption is not how PaΔpqsA responds to phage infection. Although pqsA represents a promising target for enhancing phage killing, it may not be applicable to all phages, such as types vB_Pae_W3 and vB_Pae_TR. Our findings provide new material reserves for the future design of novel phage-based therapeutic strategies.
Outcomes of COMBO therapy for severe mitral regurgitation compared with transcatheter edge-to-edge repair
Authors: Yokoyama Hiroaki , Ruf Tobias Friedrich , Gößler Theresa Ann Maria , Geyer Martin , Zirbs Julia , Schwidtal Ben Luca , Münzel Thomas , von Bardeleben Ralph Stephan 
Published: February 2024

BackgroundThere are different types of transcatheter mitral valve repair (TMVr) currently in clinical use, including leaflet approximation, annular cinching, and restoration of the chordal apparatus of the mitral valve (MV). While the concomitant combination (COMBO) therapy of mitral transcatheter edge-to-edge repair (M-TEER) with another TMVr concept has been proven feasible, potentially offering patient-tailored treatment for severe mitral regurgitation (MR), a comparison with M-TEER alone has not been made.AimsTo evaluate the procedural and clinical outcome of COMBO therapies compared with M-TEER alone.MethodsWe included consecutive patients undergoing COMBO and M-TEER between March 2015 and April 2018 at our Heart Valve Center, while excluding patients presenting a case of redo or with previous MV surgery. Procedural outcomes and all-cause mortality were compared between COMBO therapy vs. M-TEER alone.ResultsA total of 357 patients (mean age 78.9 ± 7.0 years, 53.2% male, M-TEER n = 322, COMBO n = 35; COMBO: MitraClip and the Carillon mitral contour system n = 26, MitraClip and Cardioband n = 5, and MitraClip and NeoChord n = 4) were analyzed. Patients with COMBO therapy had larger left chamber sizes, a lower left ventricular systolic ejection fraction (LVEF; COMBO: 37.4 ± 13.8%, M-TEER: 47.9 ± 14.3%, p &lt; 0.001), and a more severe MR grade (p &lt; 0.001). There were no significant differences in the prevalence of residual MR ≧2+. However, the need for re-intervention, always employing M-TEER, was more common in the COMBO group. During a mean 3.6-year long-term follow-up, there was no significant difference of all-cause mortality between both groups (Log rank p = 0.921).ConclusionsCOMBO therapy may still be a beneficial therapy option for patients with severe MR who already have a more dilated left ventricle (LV), a more severe MR, and a more pronounced LV systolic dysfunction. The higher need for re-intervention in the COMBO group may signal more complex anatomies and possibly underlines the necessity of treating significant MR earlier. Future research is required to establish the COMBO approach as a toolbox-like treatment option, thus offering a patient-tailored approach depending on the individual anatomy and pathology.
Development and validation of mortality prediction models for heart transplantation using nutrition-related indicators: a single-center study from China
Authors: Qian Shirui , Cao Bingxin , Li Ping , Dong Nianguo 
Published: February 2024

ObjectiveWe sought to develop and validate a mortality prediction model for heart transplantation (HT) using nutrition-related indicators, which clinicians could use to identify patients at high risk of death after HT.MethodThe model was developed for and validated in adult participants in China who received HT between 1 January 2015 and 31 December 2020. 428 subjects were enrolled in the study and randomly divided into derivation and validation cohorts at a ratio of 7:3. The likelihood-ratio test based on Akaike information was used to select indicators and develop the prediction model. The performance of models was assessed and validated by area under the curve (AUC), C-index, calibration curves, net reclassification index, and integrated discrimination improvement.ResultThe mean (SD) age was 48.67 (12.33) years and mean (SD) nutritional risk index (NRI) was 100.47 (11.89) in the derivation cohort. Mortality after HT developed in 66 of 299 patients in the derivation cohort and 28 of 129 in the validation cohort. Age, NRI, serum creatine, and triglyceride were included in the full model. The AUC of this model was 0.76 and the C statistics was 0.72 (95% CI, 0.67–0.78) in the derivation cohort and 0.71 (95% CI, 0.62–0.81) in the validation cohort. The multivariable model improved integrated discrimination compared with the reduced model that included age and NRI (6.9%; 95% CI, 1.8%–15.1%) and the model which only included variable NRI (14.7%; 95% CI, 7.4%–26.2%) in the derivation cohort. Compared with the model that only included variable NRI, the full model improved categorical net reclassification index both in the derivation cohort (41.8%; 95% CI, 9.9%–58.8%) and validation cohort (60.7%; 95% CI, 9.0%–100.5%).ConclusionThe proposed model was able to predict mortality after HT and estimate individualized risk of postoperative death. Clinicians could use this model to identify patients at high risk of postoperative death before HT surgery, which would help with targeted preventative therapy to reduce the mortality risk.
Identifying major phases in the use of land, energy and changing landscapes by agrarian societies (7,000 cal BP-Present) in Cantabrian Spain, based on cultural changes and anthropogenic signals
Authors: Martinez Alexandre , Zapolska Anhelina , Arthur Frank , Verhagen Philip , Kluiving Sjoerd , Muñoz-Rojas José , Borja Barrera César , Fraile Jurado Pablo 
Published: February 2024

IntroductionEnacting transitions toward more sustainable management and use of land, energy, and natural resources poses multiple challenges for human societies. Such transitions have been a constant throughout human history and therefore there is a need to learn from them and apply that knowledge to current land-use policies and management. Significant human impact on landscape and environment in Cantabrian Spain has been documented in alignment with the Neolithization (ca. 7,000 cal BP). While the classic approach of identifying cultural phases based on historical and archaeological data has been extensively studied, much less is understood on how such phases are dependent upon increasing anthropogenic influence on the environment.MethodsCantabrian Spain is well-known for its long mining history. Key processes historically shaping landscapes in the region include the implementation of mining/metallurgy industries and extraction of forest resources. These historical processes were characterized, respectively using heavy metal pollution contents (Hg, Zn, Cd, As, Ni, REE, Pb, and 206 Pb/207 Pb) and total arboreal pollen percentages in peat bogs, providing global trends of human impact on the environment. These trends were then compared to climate (temperature and precipitation) and natural vegetation evolution modeling through time.ResultsResults show seven phases of major human impact on the environment: (1) the Copper phase ca. 4,400–4,100 cal BP, (2) the Middle Bronze phase ca. 3,500–3,150 cal BP, (3) the Iron phase ca. 2,800–2,500 cal BP, (4) the Roman phase ca. 2,200–1,750 cal BP, (5) the Medieval phase ca. 1,250–1,000 cal BP, (6) the Colonial phase ca. 650–400 cal BP, and (7) the Industrial phase ca. 150 cal BP-Present.DiscussionFour phases are tightly related to substantial changes in land use and subsistence strategies: (1) Production, with the appearance of productive economies during the Neolithic, (2) Specialization, with the appearance of specialized activities and trade during the Middle Bronze phase, (3) Urbanization, with the first urban centers during the Roman phase, and (4) Globalization, with worldwide colonialism and capitalism economies during the Colonial phase.
Serum fetuin-a and risk of thoracic aortic aneurysms: a two-sample mendelian randomization study
Authors: Chen Yang , Zhu Jiayi , Guo Xin , Cao Chenghui , Xiao Xuan , Zhu Botao , Weng Shuwei , Hu Die , Luo Yonghong , Wang Shuai , Wu Sha , He Jia , Yang Yang , Peng Daoquan 
Published: February 2024

BackgroundRecent studies have revealed a significant decrease in serum fetuin-A levels in atherosclerotic aneurysms, indicating that fetuin-A may play a protective role in the progression of arterial calcification. However, the specific mechanism behind this phenomenon remains unclear. We aimed to examine the association between fetuin-A levels in thoracic aortic aneurysms (TAAs) and risk of TAAs and to evaluate whether this association was causal.MethodsA total of 26 SNPs were selected as instrumental variables for fetuin-A in 9,055 participants of European ancestry from the CHARGE consortium, and their effects on thoracic aortic aneurysm and decreased descending thoracic aortic diameter were separately estimated in 353,049 and 39,688 individuals from FinnGen consortium. We used two-sample Mendelian randomization (MR) analysis to examine the causal association. At the same time, we employed various methods, including random-effects inverse variance weighting, weighted median, MR Egger regression, and MR PRESSO, to ensure the robustness of causal effects. We assessed heterogeneity using Cochran’s Q value and examined horizontal pleiotropy through MR Egger regression and retention analysis.ResultsFetuin-A level was associated with a significantly decreasing risk of thoracic aortic aneurysm (odds ratio (OR) 0.64, 95% CI 0.47 - 0.87, P = 0.0044). Genetically predicted fetuin-A was also correlated with the decreased descending thoracic aortic diameter (β = -0.086, standard error (SE) 0.036, P = 0.017).ConclusionsSerum fetuin-A level was negatively associated with risk of TTAs and correlated with the decreased descending thoracic aortic diameter. Mendelian randomization provides support for the potential causal relationship between fetuin-A and thoracic aortic aneurysm.
Comprehensive evaluation of inactivated SARS-CoV-2 vaccination on sperm parameters and sex hormones
Authors: Dong Yehao , Ba Zaihua , Qin Yining , Ma Jiao , Li Yuqi , Zhang Yingze , Yang Aijun , Chen Fei 
Published: February 2024

BackgroundThe inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine has made significant contributions to fighting the epidemic in the past three years. However, the rapid development and application raised concerns about its safety in reproductive health, especially after several studies had observed a decrease in semen parameters following two doses of mRNA SARS-CoV-2 vaccination. Thus, it is necessary to comprehensively evaluate the effect of inactivated SARS-CoV-2 vaccine on male fertility.MethodsA retrospective cohort study was conducted in the Center for Reproductive Medicine of the Affiliated Hospital of Jining Medical University between July 2021 and March 2023. A total of 409 men with different vaccination status and no history of SARS-CoV-2 infection were included in this study. Their sex hormone levels and semen parameters were evaluated and compared separately.ResultsThe levels of FSH and PRL in one-dose vaccinated group were higher than other groups, while there were no significant changes in other sex hormone levels between the control and inactivated SARS-CoV-2 vaccinated groups. Most semen parameters such as volume, sperm concentration, total sperm count, progressive motility and normal forms were similar before and after vaccination with any single dose or combination of doses (all P &gt; 0.05). Nevertheless, the total motility was significantly decreased after receiving the 1 + 2 doses of vaccine compared to before vaccination (46.90 ± 2.40% vs. 58.62 ± 2.51%; P = 0.001). Fortunately, this parameter was still within the normal range.ConclusionOur study demonstrated that any single dose or different combined doses of inactivated SARS-CoV-2 vaccination was not detrimental to male fertility. This information could reassure men who want to conceive after vaccination and be incorporated into future fertility recommendations.