bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymer-based drug-eluting stent treatment extends the time to reintervention for patients with symptomatic femoropopliteal artery disease: clinical evidence and potential economic value
Authors: Gray William A , Soga Yoshimitsu , Fujihara Masahiko , Iida Osamu , Babaev Anvar , Kawasaki Daizo , Zeller Thomas , O'Connor David , Jaff Michael R , Chavez Anna M , Müller-Hülsbeck Stefan 
Published: April 2024

Aim:
Use long-term follow-up data from the IMPERIAL study to determine whether drug-eluting polymer-based nitinol stent treatment can delay the time to repeat intervention for femoropopliteal artery disease and how such a delay may result in cost savings in a value-based episode of care.
Patients & methods:
The IMPERIAL randomized controlled trial was an international study of a paclitaxel-eluting polymer-coated stent (Eluvia, Boston Scientific, MA, USA) versus a polymer-free paclitaxel-coated stent (Zilver PTX, Cook Corporation, IN, USA) for treating lesions of the femoropopliteal arterial segment. Study patients (n = 465) had symptomatic lower limb ischemia. Safety and efficacy assessments were performed through 5 years. Mean time to first reintervention was calculated in post-hoc analysis for patients who underwent a clinically driven target lesion revascularization (CD-TLR) through 3 or 5 years following the index procedure. To simulate potential cost savings associated with differential CD-TLR burden over time, a cost-avoidance analysis using input parameters from IMPERIAL and US 100% Medicare standard analytical files was developed.
Results:
Among patients with a first CD-TLR through 3 years of follow-up, mean time to reintervention was 5.5 months longer (difference 166 days, 95% CI: 51, 282 days; p = 0.0058) for patients treated with Eluvia (n = 56) than for those treated with Zilver PTX (n = 30). Through the 5-year study follow-up period, CD-TLR rates were 29.3% (68/232) for Eluvia and 34.2% (39/114) for Zilver PTX (p = 0.3540) and mean time to first reintervention exceeded 2 years for patients treated with Eluvia at 737 days versus 645 days for the Zilver PTX group (difference 92 days, 95% CI: -85, 269 days; p = 0.3099). Simulated savings considering reinterventions occurring over 1 and 5 years following initial use of Eluvia over Zilver PTX were US $1,395,635 and US $1,531,795, respectively, when IMPERIAL CD-TLR rates were extrapolated to 1000 patients.
Conclusion:
IMPERIAL data suggest initial treatment with Eluvia extends the time patients spend without undergoing reintervention. This extension may be associated with cost savings in relevant time frames.
Analysis of the 50 Most Impactful Publications Pertaining to COVID-19 and Orthopaedic Surgery: What Have we Learned?
Authors: Ladehoff Lauren , Harris Andrew B. , Root Kevin T. , Criscione Jaynie , Clampitt Bryan , Becsey Alexander N. , Oni Julius K. 
Published: April 2024

Purpose There has been abundant research published regarding the impact of COVID-19 on orthopaedic surgical patients which have varying degrees of impact on clinical practice. Thus, the purpose of this study was to examine the most influential articles relating to COVID-19 and patients undergoing orthopaedic surgical procedures. Though the global pandemic is over, it is beneficial to understand how the resilience of the healthcare system adapted to guide policy development and improve patient care amidst a worldwide time of crisis. Methods The Clarivate Web of Science Core Collection was searched for ‘COVID-19 AND orthopaedic surgery’ and returned 388 articles. The most influential peer-reviewed publications were determined by citation number. Expert opinion and review articles were excluded. Article title, journal name, type of study, country of publication, and clinically relevant findings of each study were collected. Results The top-50 most influential manuscripts concluded these articles were collectively cited 1875 times. The total citations ranged from 13 to 111 citations per article with a mean of 38 (95% confidence interval [31, 44]). England (14), the United States (11), and Italy (10) had the top number of publications. The top affiliations were IRCCS Istituto Ortopedico Galeazzi (5) and the University of London (4). The most popular journals were Bone & Joint Open (10) and International Orthopaedics (10). Though the articles were largely heterogeneous, they described the necessity of orthopaedic surgeons during the pandemic as well as safety precautions to prevent COVID-19 transmission in orthopaedic patients. Conclusion This comprehensive analysis identified the 50 most influential peer-reviewed clinical publications regarding COVID-19 and orthopaedic surgery, which is a concise resource that can be used to inform patient decision-making regarding orthopaedic care and COVID-19. The top-50 articles highlighted the importance of resource utilization, increased use of telemedicine, enhanced infection control measures, patient-centered care, and the well-being of healthcare workers during the COVID-19 pandemic.
Evaluation of clinical examination and preoperative imaging in patients with right iliac fossa pain and a medium or high risk score for appendicitis (RIFT-2)
Authors: RIFT Study Group  
Published: April 2024

Introduction: Clinical risk models can be used to safely stratify UK patients with suspected appendicitis with low scores to ambulatory pathways, preventing admissions and unnecessary surgery. This study aimed to examine the diagnostic pathways in patients with medium or high risk scores.
Methods: This prospective cohort study included patients admitted with suspected appendicitis in the UK. Patients aged ≥16 years were included if they had a medium or high risk score for appendicitis (Appendicitis Inflammatory Response score >2 in men, Adult Appendicitis Score >8 in women). The primary outcome measure was the normal appendicectomy rate (NAR). The AIRS and AAS risk prediction models were validated against pre-determined criteria.
Results: This UK study included 2,231 women and 1,958 men. Overall, 57.7% of patients underwent surgery. The NAR was 18.4% in women aged 16-45 years, 9.5% in men aged 16-45 years, 4.5% in women aged ≥46 years, and 2.1% in men aged ≥46 years. Risk prediction models did not achieve the pre-determined threshold to be used to identify patients with appendicitis. Ultrasound was the most common imaging modality in women aged 16-45 years, whereas CT was most common in the other subgroups. CT was performed in 12.8% women aged 16-45 years, 21.1% in men aged 16-45 years, 69.3% in women aged ≥46 years, and 74.5% in men aged ≥46 years. The overall NAR in patients who had CT imaging alone (3.6%) was lower than in patients who had no imaging (12.4%) or ultrasound imaging alone (19.0%).
Conclusion: Patients with right iliac fossa pain should be risk scored, with low-risk patients triaged to ambulatory management and medium and high-risk patients routinely CT scanned. Normal appendicectomy should become a specific therapeutic option rather than a chance finding.
Analisis Penerapan SAK-EMKM Dalam Penyusunan Laporan Keuangan (Studi Kasus Pada UMKM Ligastore Makassar)
Authors: Syah Sri Rahayu , Irmawati Ika , Alacoque Margaretha 
Published: April 2024

Penelitian ini bertujuan untuk menerapkan penerapan Standar Akuntansi Keuangan Entitas Mikro, Kecil, dan Menengah (SAK-EMKM) dalam penyusunan laporan keuangan dan juga mengetahui kendala-kendala yang dihadapi dalam proses penerapan SAK-EMKM Pada UMKM Ligastore Makassar.
Metode yang digunakan dalam penelitian yaitu metode deskriptif kualitatif. Dengan teknik pengumpulan data berupa observasi, wawancara, dan dokumentasi pada UMKM Ligastore Makassar kemudian menganalisis dan membandingkan antara Standar Akuntansi Keuangan Entitas Mikro, Kecil, dan Menengah (SAK-EMKM) dengan penyusunan laporan keuangan di UMKM Ligastore Makassar.
Hasil penelitian menunjukkan bahwa: 1) UMKM Ligastore Makassar belum menerapkan SAK-EMKM pada laporan keuangannya, dilihat dari segi pencatatan, pengikhtisaran, dan pelaporan. Pemilik Ligastore hanya membuat laporan penjualan sebagai laporan keuangan, meskipun laporan tersebut tidak memenuhi standar akuntansi yang seharusnya. 2) Terdapat kendala yang menghambat penerapan SAK-EMKM pada UMKM Ligastore Makassar, antara lain kurangnya pemahaman pemilik tentang SAK-EMKM dan tidak adanya staf khusus yang bertanggung jawab dalam menyusun laporan keuangan.
Four-Bolt Unstiffened End-Plate Moment Connections with 36-in.-Deep Beams for Intermediate Moment Frames
Authors: Mercado-Celin Maria A. , Eatherton Matthew R. , Murray Thomas M. 
Published: April 2024

Previous testing has shown that four-bolt extended, unstiffened end-plate moment connections can be used with beams up to 24 in. deep and develop sufficiently ductile performance to satisfy seismic qualification. It is desirable to extend this depth limit to allow deeper beams for intermediate moment frames. Three moment connection specimens using built-up 36-in.-deep beams with a four-bolt extended, unstiffened end-plate moment connection were tested to determine if they satisfy the intermediate moment frame qualification criteria given in AISC 341-16 (2016a). The web of the specimens satisfied the moderately ductile section criteria for web slenderness, which is required for intermediate moment frames, but not highly ductile section criteria required for special moment frames.
All three specimens passed qualification criteria for intermediate moment frames (IMFs) as given in AISC 341-16 by retaining at least 80% of the nominal plastic moment strength through 2% story drift. The observed failure modes included lateral torsional buckling of the specimen, flange local buckling, net section fracture of the beam flange, and failure of the beam flange-to-beam web fillet weld. The results of these tests support current moderately ductile limits associated with lateral bracing and cross-section slenderness, given that the associated specimens reached IMF qualification criteria but not special moment frame (SMF) criteria. It was concluded that four-bolt extended, unstiffened end-plate moment connections satisfy intermediate moment frame requirements with a beam depth of 36 in. and that a modification is needed for beam web to flange welds in built-up sections near the moment connection.
Hopf bifurcations with fluctuating gain
Authors: Triana S.A. , Kelley D.H. , Zimmerman D. , Sisan D. , Lathrop D.P. 
Published: September 2008

AbstractA Hopf bifurcation describes a transition from a steady state to an oscillatory one. This report describes how the presence of white Gaussian noise in the term driving the instability (the gain) affects the character of such a transition. We find that for small noise intensities the effective critical value of the bifurcation parameter increases linearly with the noise intensity. This result is used to quantitatively describe the onset of the magneto‐rotational instability in a laboratory experiment using liquid metal with turbulent background flow. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Metal‐Controlled Anion‐Binding Tendencies of the Thiourea Unit of Thiosemicarbazones
Authors: Amendola Valeria , Boiocchi Massimo , Fabbrizzi Luigi , Mosca Lorenzo 
Published: September 2008

AbstractThe terdentate ligand 3 (LH, 2‐formylpyridine 4‐thiosemicarbazone) forms with FeII and NiII 2:1 complexes of octahedral geometry of formula [MII(LH)2]2+. X‐ray diffraction studies have shown that in both complexes the thiourea moieties of the coordinated thiosemicarbazones are exposed to the outside and are prone to establish hydrogen‐bonding bifurcate interactions with oxoanions. However, spectrophotometric studies in CHCl3 solution have shown that only the poorly basic NO3− ion is able to form authentic hydrogen‐bond complexes with thiourea subunits, whereas all the other investigated anions (CH3COO−, NO2−, F−) induce deprotonation of the N‐H fragment. The extreme enhancement of the thiourea acidity is based on the coordinative interaction of the sulphur atom with the metal, which stabilises the thiolate form, and it is much higher than that exerted by any other covalently linked electron‐withdrawing substituent, for example, NO2.
Reliability and validity of the Childhood Cancer Survivor Study Neurocognitive Questionnaire
Authors: Krull Kevin R. , Gioia Gerard , Ness Kirsten K. , Ellenberg Leah , Recklitis Christopher , Leisenring Wendy , Huang Sujuan , Stovall Marilyn , Robison Leslie L. , Zeltzer Lonnie 
Published: September 2008

AbstractBACKGROUND.Up to 40% of childhood cancer survivors may experience neurocognitive impairment in 1 or more specific domains. As such, regular monitoring has been recommended for patients exposed to cranial irradiation and/or antimetabolite chemotherapy. This study reports the results of a questionnaire developed to identify those survivors who may be experiencing neurocognitive problems.METHODS.Participants for this study were 7121 members of the Childhood Cancer Survivor Study cohort (6739 survivors and 382 siblings). These participants completed a new neurocognitive questionnaire designed to assess functions commonly affected by cancer therapy, as well as a standard measure of emotional functioning. A measure of cognitive and emotional functioning was also completed on a subset of the patients roughly 7 years before the current questionnaire. Responses to the questionnaires among subgroups of survivors were then analyzed to examine the reliability and validity of the new neurocognitive questionnaire.RESULTS.Four reliable factors were identified that assessed task efficiency, emotional regulation, organization, and memory skills. These neurocognitive factors accurately discriminated survivors who were at “high risk” for neurocognitive dysfunction, because of neurologic abnormalities or a history of intensive focal cranial irradiation, from healthy “low‐risk” survivors and siblings.CONCLUSIONS.The questionnaire demonstrated excellent reliability, as well as construct and discriminative validity. It appears to be a practical and efficient tool for monitoring neurocognitive outcomes in adult survivors of pediatric cancer. Cancer 2008. © 2008 American Cancer Society.
Serum interleukin‐6 predicts the development of multiple symptoms at nadir of allogeneic hematopoietic stem cell transplantation
Authors: Wang Xin Shelley , Shi Qiuling , Williams Lori A. , Cleeland Charles S. , Mobley Gary M. , Reuben James M. , Lee Bang‐Ning , Giralt Sergio A. 
Published: September 2008

AbstractBACKGROUND.During the time of lowest white blood cell count (nadir) of allogeneic hematopoietic stem cell transplantation (allo‐HSCT), cancer patients suffer from tremendous symptom burden related to therapy that requires intensive patient care. However, the mechanism underlying the development of multiple symptoms has not been established.METHODS.To explore the role of inflammatory cytokines in the development of treatment‐related symptoms, we studied dynamic changes in symptoms and in serum concentrations of inflammatory cytokines (interleukin [IL]‐6, IL‐8, soluble tumor necrosis factor receptor 1 [sTNF‐R1], IL‐1 receptor antagonist, and IL‐12p40p70) from pretherapy throughout the first 30 days of allo‐HSCT in 30 patients with acute myelogenous leukemia or myelodysplastic syndrome. We measured multiple symptoms repeatedly using the M. D. Anderson Symptom Inventory. Mixed‐effects modeling was used to analyze longitudinal data.RESULTS.In response to conditioning and stem‐cell infusion, serum levels of IL‐6 and the severity of multiple symptoms increased rapidly and peaked at nadir. From baseline to nadir (approximately Day 8 post‐transplantation), increase in IL‐6 was significantly associated with worsening of the most severe symptoms (fatigue, poor appetite, pain, drowsiness, dry mouth, and disturbed sleep; P< .01). During the first 30 days after transplantation, increases in IL‐6 (P< .001) and sTNF‐R1 (P< .05) significantly predicted the increasing severity of these symptoms.CONCLUSIONS.These results suggest that release of systemic inflammatory cytokines, mainly IL‐6, corresponds to an increase in treatment‐related multiple‐symptom burden during the nadir period of allo‐HSCT. Cancer 2008. © American Cancer Society.
Circulating tumor cells in metastatic breast cancer
Authors: Dawood Shaheenah , Broglio Kristine , Valero Vicente , Reuben James , Handy Beverly , Islam Rabiul , Jackson Summer , Hortobagyi Gabriel N. , Fritsche Herbert , Cristofanilli Massimo 
Published: September 2008

AbstractBACKGROUND.The aim of the current study was to assess the prognostic value of baseline circulating tumor cells (CTCs) in a large cohort of patients with newly diagnosed metastatic breast cancer (MBC).METHODS.This retrospective study included 185 patients with newly diagnosed MBC evaluated between 2001 and 2007. CTCs were isolated and enumerated before patients started first‐line treatment using the CellSearch system. Overall survival (OS) was calculated from the date of CTC measurement, estimated by the Kaplan‐Meier product limit method, and compared between groups with the log‐rank test. Cox proportional hazards models were fitted to determine the association between CTC levels and OS after controlling for other prognostic factors.RESULTS.The median age of the patients at the time of MBC diagnosis was 49 years. Fifty‐six (30.3%) patients presented with de novo metastatic disease, and 129 (69.7%) presented with newly recurrent breast cancer. A total of 114 patients (61.6%) had CTC <5, and 71 (38.4%) had CTC ≥5. The median OS was 28.3 months and 15 months (P < .0001) for patients with CTC <5 and CTC ≥5, respectively. Superior survival among patients with CTC <5 was observed regardless of hormone receptor and HER‐2/neu status, site of first metastases, or whether the patient had recurrent or de novo metastatic disease. In the multivariate model, patients with CTC ≥5 had a hazards ratio of death of 3.64 (95% confidence interval, 2.11‐6.30) compared with patients with CTC <5.CONCLUSIONS.The results of this large retrospective study confirms that CTCs are a strong independent predictor of survival among women with either de novo or newly recurrent MBC. CTCs should be considered as a new stratification method for women with newly diagnosed MBC. Cancer 2008. © 2008 American Cancer Society.
Infrared Spectroscopy of a Wilkinson Catalyst in a Room‐Temperature Ionic Liquid
Authors: Kiefer Johannes , Obert Katharina , Himmler Simone , Schulz Peter S. , Wasserscheid Peter , Leipertz Alfred 
Published: September 2008

AbstractHomogeneous catalysis in room‐temperature ionic liquids (ILs) constitutes a most interesting field of research with high potential in technical applications. As concerns the hydrogenation of unsaturated hydrocarbons, Wilkinson’s compound RhCl(PPh3)3 represents a catalyst that provides high selectivity and activity. Herein, we demonstrate the application of infrared spectroscopy to the quantitative analysis of the Wilkinson catalyst in the IL 1‐ethyl‐3‐methylimidazolium acetate ([EMIM][OAc]). Our study demonstrates for the first time the quantitative, accurate and reproducible determination of the concentration of a rhodium catalyst by means of IR spectroscopy and, moreover, allows the investigation of intermolecular interactions. Spectral features, located mainly in the fingerprint region of the IR spectrum, are identified revealing the influence of the dissolved catalyst on the IL’s vibrational structure. In particular, the ring‐bending mode of the imidazolium ring shows a frequency shift as a function of catalyst concentration, probably due to hydrogen‐bond formation between the IL cation and the Rh complex. The results show the potential of IR spectroscopy both for application as a quick process control technology in catalytic processes and as a tool for better understanding of IL–catalyst interactions.
Phenotype and function of human T lymphocyte subsets: Consensus and issues
Authors: Appay Victor , van Lier Rene A. W. , Sallusto Federica , Roederer Mario 
Published: September 2008

AbstractIn recent years, a tremendous effort has been devoted to the detailed characterization of the phenotype and function of distinct T cell subpopulations in humans, as well as to their pathway(s) of differentiation and role in immune responses. But these studies seem to have generated more questions than definitive answers. To clarify issues related to the function and differentiation of T cell subsets, one session of the MASIR 2008 conference was dedicated to this topic. Several points of consensus and discord were highlighted in the work presented during this session. We provide here an account of these points, including the relative heterogeneity of T cell subpopulations during infections with distinct pathogens, the relationship between phenotypic and functional T cell attributes, and the pathway(s) of T cell differentiation. Finally, we discuss the problems which still limit general agreement. Published 2008 Wiley‐Liss, Inc.
Influence of a Pyrazyl Linker on the Physicochemical Properties of Homodinuclear Bis(cyclen) and Bis(cyclam) Complexes
Authors: El Ghachtouli Sanae , Cadiou Cyril , Déchamps‐Olivier Isabelle , Chuburu Françoise , Aplincourt Michel , Roisnel Thierry , Turcry Véronique , Patinec Véronique , Le Baccon Michel , Handel Henri 
Published: September 2008

AbstractCuII and NiII complexes of bis(cyclen)pyrazine and bis(cyclam)pyrazine, [Cu2L1]4+, [Ni2L1]4+, [Cu2L2]4+, [Ni2L2]4+, have been isolated and characterised by UV/Vis and EPR spectroscopy. Complex [Cu2L1]4+ was characterised by X‐ray diffraction. The crystallographic structure indicated that the two metal cations are held in a square‐pyramidal geometry, the central nitrogen pyrazine atoms occupying the apical position of each metal centre. In solution, the EPR spectrum of [Cu2L1]4+ revealed the presence of two isomers, one of which was the previous crystallised complex. For [Ni2L2]4+, the electrochemical studies have highlighted the presence of two distinct geometries for the complex (type III and type V). From the electronic point of view, EPR and electrochemical measurements indicated that in these complexes the pyrazine bridge behaves as a poorly efficient exchange bridging ligand between the two metal centres. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Mutual liking and meta‐perception accuracy
Authors: Ohtsubo Yohsuke , Takezawa Masanori , Fukuno Mitsuteru 
Published: September 2008

AbstractThe present study investigated the underlying mechanism yielding a positive correlation between dyad members' mutual liking and meta‐accuracy (i.e., dyad members who like each other tend to be accurate in judging how their partner sees them). Two pilot studies were first conducted to confirm the presence of the positive correlation. The main study was conducted to test several possible explanations for the observed positive correlation. In the main study, each participant took part in a series of brief interactions with an unacquainted opposite‐sex partner three times. In each interaction, participants rated their liking for the partner, evaluated their impression of the partner on 15 items, and finally inferred the partner's impression of them on the same 15 items. The meta‐accuracy was operationally defined as the correlation between the partner's impression and the participant's inference. Neither of the two types of unilateral liking (i.e., participant's liking for the partner nor the partner's liking for the participant) predicted meta‐accuracy. However, when both members found the partner likeable (i.e., mutual liking was present), the within‐dyad average meta‐accuracy tended to be high. The implications of these results for meta‐perception research are discussed on the basis of Brunswik's lens model framework. Copyright © 2008 John Wiley & Sons, Ltd.