bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online-Training für Hörimplantatchirurgie
Authors: Rak Kristen , Kaulitz Stefan , Voelker Johannes , Müller-Graff Tassilo , Engert Jonas , Spahn Björn , Hackenberg Stephan , Grasso Peter , Hagen Rudolf 
Published: March 2024

Zusammenfassung
Ziel
Angehende Otologen stehen vor der Herausforderung, die komplexen mikrochirurgischen Techniken insbesondere im Zusammenhang mit Mittelohreingriffen und Cochleaimplantationen zu beherrschen. Traditionelle mikrochirurgische Ausbildungsmethoden beinhalten klassischerweise Präparationsübungen an Post-mortem-Präparaten und die begleitete Operation unter direkter Anleitung und Aufsicht. Dies setzt entsprechend voraus, Zugang zu Präparaten zu haben, und die Möglichkeit, von erfahrenen Chirurgen im eigenen Haus angeleitet zu werden. Da dies nicht ubiquitär umzusetzen ist, wurde ein Online-Trainingssystem für otologische Eingriffe entwickelt.

Material und Methoden
Das System besteht aus einem künstlichen Modell des Schläfenbeins und den regulären chirurgischen Instrumenten und Übungsimplantaten. Zentraler Bestandteil ist eine hochauflösende Kamera, die mit einer Video-Streaming-Plattform verbunden ist und eine Online-Supervision der chirurgischen Schritte der Auszubildenden durch erfahrene Otochirurgen ermöglicht. Darüber hinaus wurde eine Pre-Learning-Plattform entwickelt, die die Anatomie des Felsenbeins, Information zum Instrumentarium sowie aufgezeichnete Vorlesungen und Lehrvideos umfasst, die es den Auszubildenden ermöglicht, ihr Wissen vor der praktischen Übung zu überprüfen und zu vertiefen.

Ergebnisse
In den 3 bisher durchgeführten Kursen haben insgesamt 28 Teilnehmer mit unterschiedlicher chirurgischer Erfahrung an diesem Online-Fortbildungsprogramm für Otochirurgie teilgenommen. Mithilfe eines Fragebogens wurde die subjektive Bewertung des Programms durch die Teilnehmer abgefragt. So konnten auch Bereiche identifiziert werden, in denen eine Optimierung zu einer noch solideren Fortbildungserfahrung führen könnte.

Schlussfolgerung
Das vorgestellte Programm einer otochirurgischen Online-Ausbildung kann dazu beitragen, bestimmte Basisgrundsätze im „Remote-Verfahren“ zu vermitteln. Damit wird diese Möglichkeit eines otochirurgischen Trainings auch Ärztinnen und Ärzten ermöglicht, die keinen unmittelbaren Zugang zu den klassischen Vor-Ort-Trainingseinheiten haben.
A year in pharmacology: new drugs approved by the US Food and Drug Administration in 2023
Authors: Kayki-Mutlu Gizem , Aksoyalp Zinnet Sevval , Wojnowski Leszek , Michel Martin C. 
Published: March 2024

AbstractWith 54 new drugs and seven cellular and gene therapy products, the approvals by the US Food and Drug Administration (FDA) recovered 2023 from the 2022 dent back to the levels of 2020–2021. As in previous years of this annual review, we assign these new drugs to one of three levels of innovation: first drug against a condition (“first-in-indication”), first drug using a novel molecular mechanism (“first-in-class”), and “next-in-class,” i.e., a drug using an already exploited molecular mechanism. We identify four (7%) “first-in-indication,” 22 (36%) “first-in-class,” and 35 (57%) “next-in-class” drugs. By treatment area, rare diseases (54%) and cancer drugs (23%) were once again the most prevalent (and partly overlapping) therapeutic areas. Other continuing trends were the use of accelerated regulatory approval pathways and the reliance on biopharmaceuticals (biologics). 2023 marks the approval of a first therapy based on CRISPR/Cas9 gene editing.
Tip of the iceberg: unveiling the impact on back disorders from cumulative physical job exposure and evaluating bias from the healthy worker effect using a nationwide longitudinal cohort study
Authors: Wiben Amalie , Skovsgaard Christian , Søgaard Karen , Schiøttz-Christensen Berit , Olsen Kim Rose 
Published: March 2024

Abstract
Purpose
Longitudinal studies across various sectors with physically demanding jobs are notably absent in back disorder risk research. This study aimed to investigate the relationship between cumulative physical job exposure (PJE) and hospital-diagnosed back disorders among individuals in Denmark. To assess the healthy worker effect, we compared the cumulative risk estimate with results from a naive cross-sectional model ignoring PJE history.

Methods
A nationwide longitudinal cohort study was conducted using Danish registers, encompassing individuals born between 1975 and 1978 and working in 1996. Cumulative PJE was measured with a 10-year look-back period for each year 2006–2017. PJE consisted of lower-body occupational exposures, including the total weight lifted, stand/sit ratio, and the frequency of lifting more than 20 kg per day from a job exposure matrix. Odds ratio for back disorders was estimated for each year and all years combined.

Results
The results unveiled a significant 31% increase in the risk of hospital-diagnosed back disorders after 4 years of cumulative PJE. The lowest risk (7%) was observed for incident back disorders with 1 year of exposure, suggesting a healthy worker effect. Nevertheless, this risk is still significantly elevated. This cumulative estimate is fourfold the estimate from the 2006 naive cross section model.

Conclusion
Our study clearly demonstrates an 31% increase in the risk of hospital-diagnosed back disorders with just 4 years of PJE over a 10-year period. Further, we find that cross-sectional studies strongly underestimate the risk of back disorders due to the healthy worker effect.
Inhibitory control in teleost fish: a methodological and conceptual review
Authors: Lucon-Xiccato Tyrone 
Published: March 2024

Abstract
Inhibitory control (IC) plays a central role in behaviour control allowing an individual to resist external lures and internal predispositions. While IC has been consistently investigated in humans, other mammals, and birds, research has only recently begun to explore IC in other vertebrates. This review examines current literature on teleost fish, focusing on both methodological and conceptual aspects. I describe the main paradigms adopted to study IC in fish, identifying well-established tasks that fit various research applications and highlighting their advantages and limitations. In the conceptual analysis, I identify two well-developed lines of research with fish examining IC. The first line focuses on a comparative approach aimed to describe IC at the level of species and to understand the evolution of interspecific differences in relation to ecological specialisation, brain size, and factors affecting cognitive performance. Findings suggest several similarities between fish and previously studied vertebrates. The second line of research focuses on intraspecific variability of IC. Available results indicate substantial variation in fish IC related to sex, personality, genetic, age, and phenotypic plasticity, aligning with what is observed with other vertebrates. Overall, this review suggests that although data on teleosts are still scarce compared to mammals, the contribution of this group to IC research is already substantial and can further increase in various disciplines including comparative psychology, cognitive ecology, and neurosciences, and even in applied fields such as psychiatry research.
Multidrug-resistant organism bloodstream infection and hospital acquisition among inpatients in three tertiary Greek hospitals during the COVID-19 era
Authors: Karakosta Polyxeni , Vourli Sophia , Kousouli Elisavet , Meletis Georgios , Tychala Areti , Louka Christina , Vasilakopoulou Alexandra , Protonotariou Efthymia , Mamali Vasiliki , Zarkotou Olympia , Skoura Lemonia , Pournaras Spyros 
Published: March 2024

AbstractFrom 2019 (pre-COVID-19) to 2022 (COVID-19 years), three tertiary Greek hospitals monitored MDRO bloodstream infection (BSI) and hospital acquisition relying on laboratory data. Surveillance covered carbapenem-resistant Enterobacterales (CRE), Acinetobacter baumannii (CRAB), Pseudomonas aeruginosa (CRPA), vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA), in intensive care units (ICUs) and non-ICUs. Non-ICUs experienced significant increases in CRE, CRAB and VRE during the pandemic. In ICUs, CRE increased in 2021, CRAB in 2020 and 2021, and VRE in 2021 and 2022. KPC predominated among CRE. MDRO BSI and hospital acquisition incidence rates increased, driven by CRE and CRAB.
A reliable method for data aggregation on the industrial internet of things using a hybrid optimization algorithm and density correlation degree
Authors: Heidari Arash , Shishehlou Houshang , Darbandi Mehdi , Navimipour Nima Jafari , Yalcin Senay 
Published: March 2024

AbstractThe Internet of Things (IoT) is a new information technology sector in which each device may receive and distribute data across a network. Industrial IoT (IIoT) and related areas, such as Industrial Wireless Networks (IWNs), big data, and cloud computing, have made significant strides recently. Using IIoT requires a reliable and effective data collection system, such as a spanning tree. Many previous spanning tree algorithms ignore failure and mobility. In such cases, the spanning tree is broken, making data delivery to the base station difficult. This study proposes an algorithm to construct an optimal spanning tree by combining an artificial bee colony, genetic operators, and density correlation degree to make suitable trees. The trees’ fitness is measured using hop count distances of the devices from the base station, residual energy of the devices, and their mobility probabilities in this technique. The simulation outcomes highlight the enhanced data collection reliability achieved by the suggested algorithm when compared to established methods like the Reliable Spanning Tree (RST) construction algorithm in IIoT and the Hop Count Distance (HCD) based construction algorithm. This proposed algorithm shows improved reliability across diverse node numbers, considering key parameters including reliability, energy consumption, displacement probability, and distance.
Factors Influencing People’s Willingness to Shift Their Electricity Consumption
Authors: Hardmeier M. , Berthold A. , Siegrist M. 
Published: March 2024

AbstractAs the share of renewable energy sources, which are weather dependent and consequently volatile, continues to grow, it becomes increasingly important to explore strategies for organising both electricity production and consumption to ensure system stability. People’s flexibility in their energy consumption is one option to regulate the system. To better understand people’s willingness to align their electricity-consuming activities with a flexible pricing system, an online survey with 962 respondents was conducted. The analysis focused on the factors influencing their willingness to shift electricity-consuming activities away from peak hours, as well as the maximum shift duration of using certain devices. The results indicate that people with more flexible lifestyles and those who perceive shifting activities as taking less effort are more willing to shift their activities and indicate longer shift durations. The data also show that attitudes towards the environment, as well as financial, ecological, and motivational factors, play a role in explaining the variance in the willingness to shift and the shift duration. To conclude, increasing flexibility in everyday life could make a valuable contribution to the optimal use of electricity resources.
Harmonic expansion and nonsmooth dynamics in a circular contact region with combined slip-spin motion
Authors: Antali Mate 
Published: March 2024

AbstractWe analyse a rigid body in planar motion while touching a rough plane at a finite-sized, circular contact area. Assuming Coulomb friction between the tangential and normal pressure distributions, the resultant forces and torques can be expressed formally with a nonsmooth dependence on the kinematic variables. In the literature, the exact form of the tangential forces is available for special pressure distributions expressed by transcendent functions; recently, an approximate linear model was introduced. Now, we present a nonlinear extension of the approximation, which can be used effectively to characterise slipping-sticking transitions between the bodies.
A Compact Dual-polarized Probe-fed UWB Antenna System for Breast Cancer Detection Applications
Authors: Nawati Vanishree R , Sujatha B. K. , Karthikeya G. S. , Desai Arpan , Hsu Heng Tung , Palandoken Merih 
Published: March 2024

AbstractThis article proposes an electrically small, probe-fed Ultra-Wideband (UWB) monopole antenna on a slotted truncated ground plane for breast cancer detection. The physical footprint of the proposed antenna element is 33 mm × 35 mm × 0.5 mm. This element is designed on the low-cost FR4 Epoxy substrate with a thickness of 0.5 mm. The proposed antenna has an electrical size of 0.33λ × 0.35λ × 0.005λ at the lowest frequency of operation; the radiator offers an impedance bandwidth of 8.34 GHz, which implies a fractional bandwidth of 115.5%. A compact dual-polarized antenna topology with two orthogonally placed probe-fed monopole antennas is proposed to achieve polarization diversity. The impedance characteristics of the individual radiating elements are maintained in spite of the electrical proximity of the radiators. The numerically computed and experimentally measured results of dual-polarized electrically small UWB antenna agree quite well. The proposed dual-polarized antenna topology is investigated for its utility in breast cancer detection in simulation.
A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age
Authors: McGee Kirsty C. , Sullivan Jack , Hazeldine Jon , Schmunk Lisa J. , Martin-Herranz Daniel E. , Jackson Thomas , Lord Janet M. 
Published: March 2024

AbstractAn increase in systemic inflammation (inflammaging) is one of the hallmarks of aging. Epigenetic (DNA methylation) clocks can quantify the degree of biological aging and this can be reversed by lifestyle and pharmacological intervention. We aimed to investigate whether a multi-component nutritional supplement could reduce systemic inflammation and epigenetic age in healthy older adults.We recruited 80 healthy older participants (mean age ± SD: 71.85 ± 6.23; males = 31, females = 49). Blood and saliva were obtained pre and post a 12-week course of a multi-component supplement, containing: Vitamin B3, Vitamin C, Vitamin D, Omega 3 fish oils, Resveratrol, Olive fruit phenols and Astaxanthin. Plasma GDF-15 and C-reactive protein (CRP) concentrations were quantified as markers of biological aging and inflammation respectively. DNA methylation was assessed in whole blood and saliva and used to derive epigenetic age using various clock algorithms.No difference between the epigenetic and chronological ages of participants was observed pre- and post-treatment by the blood-based Horvath or Hannum clocks, or the saliva-based InflammAge clock. However, in those with epigenetic age acceleration of ≥ 2 years at baseline, a significant reduction in epigenetic age (p = 0.015) and epigenetic age acceleration (p = 0.0058) was observed post-treatment using the saliva-based InflammAge clock. No differences were observed pre- and post-treatment in plasma GDF-15 and CRP, though participants with CRP indicative of an elevated cardiovascular disease risk (hsCRP ≥ 3µg/ml), had a reduction in CRP post-supplementation (p = 0.0195).Our data suggest a possible benefit of combined nutritional supplementation in individuals with an accelerated epigenetic age and inflammaging.
Spontaneous imbibition of modified salinity brine into different lithologies: an improvement of comprehensive scaling used for fractured reservoir simulation
Authors: Bassir Seyed Mojtaba , Shokrollahzadeh Behbahani Hassan , Shahbazi Khalil , Kord Shahin 
Published: March 2024

AbstractSpontaneous water imbibition into matrix blocks can be a significant oil recovery mechanism in fractured reservoirs. Many enhanced oil recovery methods, such as injection of modified salinity brine, are proposed for improving spontaneous imbibition efficacy. Many scaling equations are developed in the literature to predict spontaneous imbibition oil recovery. However, almost none of them included the impact of the diversity in ionic composition of injected and connate brines and the blending/interaction of a low salinity imbibing brine with a higher salinity connate brine. In this research, these two issues are included to propose new scaling equations for the scaling of spontaneous imbibition oil recovery by modified salinity imbibing brines. This study uses experimental data of the spontaneous imbibition of modified salinity brines into oil-saturated rock samples with different lithologies containing an irreducible high salinity connate brine. The collected tests from the literature were performed at high temperatures and on aged altered wettability cores. The results of 110 available spontaneous imbibition laboratory experiments (85, 12 and 13 tests on chalks, dolomites and sandstones, respectively) are gathered. This research initially shows the poor ability of three selected convenient scaling equations from the literature to scale imbibition recovery by modified salinity brine. Then, our newly proposed technique to find the scaling equation for spontaneous imbibition recovery by modified salinity brine, during the abovementioned conditions in limestones (Bassir et al. in J Pet Explor Prod Technol 13(1): 79–99, 2023. https://doi.org/10.1007/s13202-022-01537-7) is used in chalks, dolomites and sandstones to develop the three new scaling equations. Finally, a new general equation to scale imbibition recovery by modified salinity brine for all four lithologies is presented. Moreover, for each of the four datasets (chalk, dolomite, sandstone and all the four lithologies), the scaled data by the new equations is matched by two mathematical expressions based on the Aronofsky et al. model and the Fries and Dreyer model. These mathematical expressions can be used to develop transfer functions in reservoir simulators for a more accurate prediction of oil recovery by spontaneous imbibition of modified salinity brine in fractured reservoirs.
Preference for Immediate Rewards in Attention-Deficit/Hyperactivity Disorder and Substance Use Disorder: A Shared Intermediate Phenotype?
Authors: Scheres Anouk , Balan Martina , Paraskevopoulou Maria , Schellekens Arnt 
Published: March 2024

Abstract
Purpose of Review
This brief review explores to what extent ADHD and SUD are both associated with reward-related impulsivity, operationalized as steep delay discounting (DD). However, an integrated view on DD as a potentially shared intermediate phenotype for these frequently co-occurring conditions is lacking.

Recent Findings
Though mostly studied in separate conditions, some studies have investigated DD specifically in patients with co-occurring conditions of SUD and ADHD. In addition to reviewing literature that has documented the associations between ADHD and relatively steep DD and between SUD and relatively steep DD, we also reviewed more recent literature in which steep DD has been examined as a transdiagnostic mechanism.

Summary
Overall, literature on DD in SUD suggests a dose-response relation between SUD severity and DD. The literature suggests that relatively steep DD is a mechanism associated to (ab)use of a range of substances. As for the link between DD and ADHD, several meta-analyses reported steeper DD in individuals with ADHD than controls (medium effect sizes). Because these bodies of literature are based on studies in which the influence of comorbidity was not assessed, it is hard to conclude that relatively steep DD is directly related to the ADHD symptoms per se, or to the SUD per se. Therefore, a close inspection of more recent literature in which comorbidity was taken into account, and DD was treated as a transdiagnostic mechanism, was included here. Based on this reviewed recent work, we propose a model about the nature of the co-occurrence of ADHD, SUD, and DD. Implications of the nature of co-occurring ADHD, SUD, and relatively steep DD for prevention and intervention strategies are discussed.
Speculative Practicescapes of Learning Design and Dreaming
Authors: Costello Eamon , McDonald Jason , Macgilchrist Felicitas , Jandrić Petar , Carbonel Henrietta , Crighton Sally , Buch Anders , Peters Michael A. 
Published: March 2024

AbstractThis article addresses a serious issue that besets learning design: its over-reliance on frameworks that promise particular outcomes for individual learners that accord with pre-defined metrics. This is partly a function of the nature of learning design and development itself which is commonly seen as outcome-oriented activity that should benefit individual learners in specific ways. An alternative approach is adopted here which calls attention to other happenings at the heart of education, including positive emotions we experience that are made known through less measurable and more fleeting points of reference. Hence, we draw on sources such as poems and personal reflections in order not just to design learning but to dream it. The concept of a practicescape is invoked which serves not just to situate learning but to remind the learner that their learning experience only happens within the context of their finite lifetime. Seven practicescapes are presented and reflected on by the authors as a conversation framework for interrogating ideas of learning that owe more to dreams, poems, and possibilities than aims, objectives, or outcomes. Drawing on early Buddhist philosophy, the practicescapes attempt to honour particular affective states and conjure a heart-centred framework on which to hang speculative questions and provocations for learning design that are focused on cultivating and sustaining the most positive forms of human experience. These practicescapes are offered as a speculative learning design climbing frame that could take us from dreams of possibility to enlivened and embodied presents.
Enhanced editing efficiency in Arabidopsis with a LbCas12a variant harboring D156R and E795L mutations
Authors: Xin Cuiping , Qiao Dexin , Wang Junya , Sun Wei , Cao Zhenghong , Lu Yu , Jiang Yuanyuan , Chai Yiping , Wang Xue-Chen , Chen Qi-jun 
Published: March 2024

AbstractCas12a (Cpf1), a Class 2 Type V CRISPR/Cas nuclease, has several unique attributes for genome editing and may provide a valuable alternative to Cas9. However, a low editing efficiency due to temperature sensitivity and insufficient cleavage activity of the Cas12a nuclease are major obstacles to its broad application. In this report, we generated two variants, ttAsCas12 Ultra and ttLbCas12a Ultra harboring three (E174R, M537R, and F870L) or two (D156R and E795L) mutations, respectively, by combining the mutations from the temperature-tolerant variants ttAsCas12a (E174R) and ttLbCas12a (D156R), and those from the highly active variants AsCas12a Ultra (M537R and F870L) and LbCas12a Ultra (E795L). We compared editing efficiencies of the five resulting Cas12a variants (LbCas12a, ttLbCas12a, ttLbCas12a Ultra, AsCas12a Ultra, and ttAsCas12 Ultra) at six target sites of four genes in Arabidopsis (Arabidopsis thaliana). The variant ttLbCas12a Ultra, harboring the D156R and E795L mutations, exhibited the highest editing efficiency of all variants tested in Arabidopsis and can be used to generate homozygous or biallelic mutants in a single generation in Arabidopsis plants grown at 22 °C. In addition, optimization of ttLbCas12a Ultra, by varying nuclear localization signal sequences and codon usage, further greatly improved editing efficiency. Collectively, our results indicate that ttLbCas12a Ultra is a valuable alternative to Cas9 for editing genes or promoters in Arabidopsis.