bluuebunny/crossref_metadata_2025_split huggingface dataset:
Land–atmosphere coupling exacerbates the moisture-associated heterogeneous impacts of compound extreme events on maize yield in China
Authors: Li Zitong , Liu Weihang , Ye Tao , Chen Shuo , Liu Yiqing , Sun Ran , Zhan Ning 
Published: March 2024

Abstract
Compound climate events are major threats to crop production under climate change. However, the heterogeneity in the impact of compound events on crop yield and its drivers remain poorly understood. Herein, we used empirical approach to evaluate the impact of compound hot–dry (HD) and cold–wet (CW) events on maize yield in China at the county level from 1990 to 2016, with a special focus on the spatial heterogeneity. Our findings indicate comparable impact of extremely compound CW events (−12.8 ± 3.6%) on maize yield loss to extremely compound HD events (−11.3 ± 2.1%). The spatial pattern of compound HD and CW events impacts on maize yield was dominantly associated with moisture regime, followed by management practices and soil properties. Specifically, drier counties and counties with less fraction of clay soil and organic carbon tend to experience greater yield loss due to compound HD events, and wet condition, excessive fertilizer, clay soil and rich organic carbon aggravate the maize yield loss due to compound CW events. Moreover, the land–atmosphere coupling exacerbated the heterogeneous yield impact through divergent heat transfer. In drier regions, the greater proportion of sensible heat creates a positive feedback between drier land and hotter atmosphere. In contrast, the greater proportion of latent heat in wetter regions results in a positive feedback between wetter land and colder atmosphere. Our results highlighted a critical element to explore in further studies focused on the land–atmosphere coupling in agricultural risk under climate change.
Least-cost and 2 °C-compliant mitigation pathways robust to physical uncertainty, economic paradigms, and intergenerational cost distribution
Authors: Bossy Thomas , Gasser Thomas , Lecocq Franck , Bednar Johannes , Tanaka Katsumasa , Ciais Philippe 
Published: March 2024

Abstract
Each run of an integrated assessment models produces a single mitigation pathway consistent with stated objectives (e.g. maximum temperature) and optimizing some objective function (e.g. minimizing total discounted costs of mitigation). Even though models can be run thousands of times, it is unclear how built-in assumptions constrain the final set of pathways. Here we aim at broadly exploring the space of possible mitigation scenarios for a given mitigation target, and at characterizing the sets of pathways that are (near-)optimal, taking uncertainties into account. We produce an extensive set of CO2 emission pathways that stay below 2 °C of warming using a reduced-form climate-carbon model with a 1000 different physical states. We then identify 18 sets of quasi ‘least-cost’ mitigation pathways, under six assumptions about cost functions and three different cost minimization functions embarking different visions of intergenerational cost distribution. A first key outcome is that the absence or presence of inertia in the cost function plays a pivotal role in the resulting set of least-cost pathways. Second, despite inherent structural differences, we find common pathways across the 18 combinations in 96% of the physical states studied. Interpreting these common pathways as robust economically and in terms of intergenerational distribution, we shed light on some of their characteristics, even though these robust pathways differ for each physical state.
Decadence and Orientalism in England and Germany, 1880-1920
Authors: Herold-Zanker Katharina 
Published: March 2024

Abstract
Decadence and Orientalism in England and Germany, 1880–1920 examines the Orientalist portrayal of Middle Eastern cultures in decadent Literatures in England and Germany at the turn of the century. This book argues that the role of Orientalism in literary decadence uniquely exposes its paradoxical engagement with other cultures. In bringing together two fin-de-siècle European literatures, this comparative study makes a case for the transnational, if not imperial, nature of decadence. The East emerges as an ‘indispensable’ mediator between various versions of European decadences. The book examines the role of the East with specific reference to selected English and German authors: starting from Oscar Wilde’s Victorian vision of Egypt and Arthur Symons’s and Violet Fane’s acquaintance with Constantinople, it moves to Paul Scheerbart’s and Else Lasker-Schüler’s decadent Babylon and Assyria, and concludes by turning to Stefan George’s exclusion of the East from his poetic practice. The geographical reach of the East focuses on regions of the Eastern Mediterranean and Northern Africa. The cultural translation of specifically the Middle East into different European national contexts gains new—sometimes oppositional—meanings, avoiding a one-sided representation of both the East and the two national literatures that absorbed it. In arguing for a decadent cosmopolitanism as a model of heterogeneous inclusivity that reaches beyond the binaries established by Edward Said’s Orientalism, the present book brings twenty-first-century theories of cosmopolitanism into dialogue with art history and literature to uncover striking synergies and interdependences between the different manifestations of decadence in England and Germany.
‘Feeling Oriental’
Authors: Herold-Zanker Katharina 
Published: March 2024

Abstract
This chapter shift the focus onto German decadence. This portion of the book on Paul Scheerbart’s and German-Jewish author Else Lasker-Schüler’s Decadent Oriental fiction of the 1890s and the 1910s reads their shared Nietzschean ‘Anti-Europäertum’ [Anti-Europeanness] as a form of self-Orientalization. Scheerbart’s art historic journalism and interest in Ancient Babylon and Assyria shaped his dramas and short fiction, presenting the East as stage or mirror to Western modernity’s shortcoming. Scheerbart’s architectural writing dedicated to Glasarchitektur, however, also projects a hopeful, utopian vision which, inspired by Eastern craftsmanship, would facilitate the pacifist, transparent coming-together of a global community. More so than Symons, who sought the affiliation with Romani in England and Fane’s association with the Armenians, both authors of the Berlin Bohème longed to embody the East through their fiction, and in Lasker-Schüler’s case, also in real life. The chapter traces Lasker-Schüler creating her own auto-fictional stylization in her male Arabic alter ego, prince ‘Jussuf’, in her Orientalizing prose, and in her correspondence with British Germanist Jethro Bithell. The chapter places emphasis on the role of decadent satire and queered gender performance as tools which these authors adopted to prompt critical self-reflection on Germany’s social progress and the self-inflicted degeneration of Europe at the cusp of the First World War.
The Buried Body
Authors: Portier-Young Anathea E 
Published: March 2024

Abstract
This chapter makes three main moves. First, it argues for the interdependence of prophetic word and body. To make this point, it analyzes the story of the unnamed man of God from Judah and the old prophet of Bethel in 1 Kgs 13 as a parable about prophecy that places both word and body at prophecy’s center and inseparably links the two. It then surveys recent turns to the body and religious experience in biblical studies that lay the groundwork for analysis of biblical prophecy as an embodied phenomenon. Nonetheless, a logocentric model views the prophet primarily as mouthpiece of the deity and prophecy as word or message. After considering factors within the biblical prophetic corpus that have contributed to this logocentric model, it traces the further influence of a dualistic hierarchy of mind/word and body in the West in both ancient and modern periods.
God’s Surrogate (Exodus 3–4)
Authors: Portier-Young Anathea E 
Published: March 2024

Abstract
This chapter examines the third-person call or commissioning narrative of Moses in Exod 3–4. Earlier studies have asserted the function of prophetic call narratives to legitimate or authorize prophetic mission, forge bonds of continuity between prophets and their predecessors, and introduce salient themes found elsewhere in the prophetic book. It is argued here that the embodied encounter between prophet and deity enables and shapes the prophet’s embodied mediation between deity and people. The perceptible signs given to Moses, including the sign of his own transformed body, are guarantee, precursor, and means for performing future acts of power that transform material and social realities. Coordination of body and word in the prophet’s encounter with God lays the groundwork for a correspondingly synergistic prophetic mission.
Ecstasy
Authors: Portier-Young Anathea E 
Published: March 2024

Abstract
Chapter 7 considers prophetic ecstasy as a transformative religious experience. Debates about the existence and nature of prophetic ecstasy in the Hebrew Bible and Old Testament owe partly to prior assumptions about the characteristics of biblical prophecy and Israelite religion and partly to the phenomenological complexity and diverse forms of religious ecstasy. Modern debates are matched by polemics, conflicting assessments, and questions within the biblical texts. But ecstasy is not a marginal feature of biblical prophecy. It enabled a prophet to bridge human and divine realities through the temporary alteration of mind and body. Biblical evidence for induction techniques such as fasting, meditation, music, or rhythmic movement is slender. Prophetic ecstasy was frequently interpreted as a form of spirit possession that could produce visions or supernatural transport. Prophetic ecstasy had the power to make the deity present, reveal hidden realities, and reshape structures of power.
The Longitudinal Reciprocal Relationships of Tooth Brushing Behaviors Between Underserved Children and Their Caregivers
Authors: Endrighi Romano , Henshaw Michelle , Adams William G , Montion Erin , Park Hannah , Borrelli Belinda 
Published: March 2024

Abstract

Background
Tooth brushing is effective in preventing early childhood caries. However, it is unclear how children’s and caregiver’s tooth brushing are reciprocally related.

Purpose
The current study investigated whether the longitudinal relationships between children and caregiver tooth brushing are moderated by a caregiver-targeted child oral health intervention and caregiver depression.

Methods
Secondary analysis of a randomized clinical trial that tested whether caregiver-targeted oral health text messages (OHT) outperformed child wellness text messages (CWT) on pediatric dental caries and oral health behaviors (n = 754, mean child age = 2.9 years, 56.2% Black, 68.3% &lt;poverty level). Tooth brushing behaviors were self-reported by caregivers using a timeline follow-back method at baseline and 4, 12, and 24 months later. Caregiver depressive symptoms were self-reported at baseline. A multigroup random intercept cross-lagged panel model examined relationships between caregiver and child tooth brushing for four post hoc groupings of condition: OHT versus CWT, and caregiver depressive symptoms: high versus low.

Results
Within-participants analyses revealed that caregiver tooth brushing at Months 4 and 12 positively predicted their child’s tooth brushing at Months 12 and 24 for caregivers in the OHT condition with low depressive symptoms (i.e., moderation by depressive symptoms and condition). Similarly, children’s tooth brushing at Month 4 positively predicted caregiver tooth brushing at Month 12 for caregivers in the OHT condition with low depressive symptoms. There were no significant associations among participants in the CWT condition, regardless of depressive symptoms.

Conclusions
Child and caregiver tooth brushing have reciprocal influences, but only for those in the OHT condition with low depressive symptoms.
Single-residue linear and conformational B cell epitopes prediction using random and ESM-2 based projections
Authors: Israeli Sapir , Louzoun Yoram 
Published: March 2024

Abstract
B cell epitope prediction methods are separated into linear sequence-based predictors and conformational epitope predictions that typically use the measured or predicted protein structure. Most linear predictions rely on the translation of the sequence to biologically based representations and the applications of machine learning on these representations. We here present CALIBER ‘Conformational And LInear B cell Epitopes pRediction’, and show that a bidirectional long short-term memory with random projection produces a more accurate prediction (test set AUC=0.789) than all current linear methods. The same predictor when combined with an Evolutionary Scale Modeling-2 projection also improves on the state of the art in conformational epitopes (AUC = 0.776). The inclusion of the graph of the 3D distances between residues did not increase the prediction accuracy. However, the long-range sequence information was essential for high accuracy. While the same model structure was applicable for linear and conformational epitopes, separate training was required for each. Combining the two slightly increased the linear accuracy (AUC 0.775 versus 0.768) and reduced the conformational accuracy (AUC = 0.769).
PANCDR: precise medicine prediction using an adversarial network for cancer drug response
Authors: Kim Juyeon , Park Sung-Hye , Lee Hyunju 
Published: March 2024

Abstract
Pharmacogenomics aims to provide personalized therapy to patients based on their genetic variability. However, accurate prediction of cancer drug response (CDR) is challenging due to genetic heterogeneity. Since clinical data are limited, most studies predicting drug response use preclinical data to train models. However, such models might not be generalizable to external clinical data due to differences between the preclinical and clinical datasets. In this study, a Precision Medicine Prediction using an Adversarial Network for Cancer Drug Response (PANCDR) model is proposed. PANCDR consists of two sub-models, an adversarial model and a CDR prediction model. The adversarial model reduces the gap between the preclinical and clinical datasets, while the CDR prediction model extracts features and predicts responses. PANCDR was trained using both preclinical data and unlabeled clinical data. Subsequently, it was tested on external clinical data, including The Cancer Genome Atlas and brain tumor patients. PANCDR outperformed other machine learning models in predicting external test data. Our results demonstrate the robustness of PANCDR and its potential in precision medicine by recommending patient-specific drug candidates. The PANCDR codes and data are available at https://github.com/DMCB-GIST/PANCDR.
High-throughput prediction of enzyme promiscuity based on substrate–product pairs
Authors: Xing Huadong , Cai Pengli , Liu Dongliang , Han Mengying , Liu Juan , Le Yingying , Zhang Dachuan , Hu Qian-Nan 
Published: March 2024

Abstract
The screening of enzymes for catalyzing specific substrate–product pairs is often constrained in the realms of metabolic engineering and synthetic biology. Existing tools based on substrate and reaction similarity predominantly rely on prior knowledge, demonstrating limited extrapolative capabilities and an inability to incorporate custom candidate-enzyme libraries. Addressing these limitations, we have developed the Substrate–product Pair-based Enzyme Promiscuity Prediction (SPEPP) model. This innovative approach utilizes transfer learning and transformer architecture to predict enzyme promiscuity, thereby elucidating the intricate interplay between enzymes and substrate–product pairs. SPEPP exhibited robust predictive ability, eliminating the need for prior knowledge of reactions and allowing users to define their own candidate-enzyme libraries. It can be seamlessly integrated into various applications, including metabolic engineering, de novo pathway design, and hazardous material degradation. To better assist metabolic engineers in designing and refining biochemical pathways, particularly those without programming skills, we also designed EnzyPick, an easy-to-use web server for enzyme screening based on SPEPP. EnzyPick is accessible at http://www.biosynther.com/enzypick/.
Bias correction models for electronic health records data in the presence of non-random sampling
Authors: Kim Jiyu , Anthopolos Rebecca , Zhong Judy 
Published: March 2024

Abstract
Electronic health records (EHRs) contain rich clinical information for millions of patients and are increasingly used for public health research. However, non-random inclusion of subjects in EHRs can result in selection bias, with factors such as demographics, socioeconomic status, healthcare referral patterns, and underlying health status playing a role. While this issue has been well documented, little work has been done to develop or apply bias-correction methods, often due to the fact that most of these factors are unavailable in EHRs. To address this gap, we propose a series of Heckman type bias correction methods by incorporating social determinants of health selection covariates to model the EHR non-random sampling probability. Through simulations under various settings, we demonstrate the effectiveness of our proposed method in correcting biases in both the association coefficient and the outcome mean. Our method augments the utility of EHRs for public health inferences, as we show by estimating the prevalence of cardiovascular disease and its correlation with risk factors in the New York City network of EHRs.
Loss-of-function variants in GLMN are associated with generalized skin hyperpigmentation with or without glomuvenous malformation
Authors: Jiang Xingyuan , Yang Chao , Wang Zhaoyang , Liang Lina , Gong Zhuoqing , Huang Shimiao , Xu Zigang , Zhang Bin , Pei Xiaoping , Cai Liangqi , Wang Huijun , Lin Zhimiao 
Published: March 2024

Abstract

Background
Inherited hyperpigmented skin disorders comprise a group of entities with considerable clinical and genetic heterogenicity. The genetic basis of a majority of these disorders remains to be elucidated.

Objectives
This study aimed to identify the underlying gene for an unclarified disorder of autosomal-dominant generalized skin hyperpigmentation with or without glomuvenous malformation.

Methods
Whole-exome sequencing was performed in five unrelated families with autosomal-dominant generalized skin hyperpigmentation. Variants were confirmed using Sanger sequencing and a minigene assay was employed to evaluate the splicing alteration. Immunofluorescence and transmission electron microscopy (TEM) were used to determine the quantity of melanocytes and melanosomes in hyperpigmented skin lesions. GLMN knockdown by small interfering RNA assays was performed in human MNT-1 cells to examine melanin concentration and the underlying molecular mechanism.

Results
We identified five variants in GLMN in five unrelated families, including c.995_996insAACA(p.Ser333Thrfs*11), c.632 + 4delA, c.1470_1473dup(p.Thr492fs*12), c.1319G &gt; A(p.Trp440*) and c.1613_1614insTA(Thr540*). The minigene assay confirmed that the c.632 + 4delA mutant resulted in abolishment of the canonical donor splice site. Although the number of melanocytes remained unchanged in skin lesions, as demonstrated by immunofluorescent staining of tyrosinase and premelanosome protein, TEM revealed an increased number of melanosomes in the skin lesion of a patient. The GLMN knockdown MNT-1 cells demonstrated a higher melanin concentration, a higher proportion of stage III and IV melanosomes, upregulation of microphthalmia-associated transcription factor and tyrosinase, and downregulation of phosphorylated p70S6 K vs. mock-transfected cells.

Conclusions
We found that loss-of-function variants in GLMN are associated with generalized skin hyperpigmentation with or without glomuvenous malformation. Our study implicates a potential role of glomulin in human skin melanogenesis, in addition to vascular morphogenesis.
Real-world practice and outcomes in pilonidal surgery: Pilonidal Sinus Treatment Studying The Options (PITSTOP) cohort
Authors: Brown Steven R , Hind Daniel , Strong Emily , Bradburn Mike , Din Farhat , Lee Ellen , Lund Jon , Moffatt Christine , Morton Jonathan , Senapati Asha , Jones Helen , Lee Matthew J ,   PITSTOP Management Group, Ali K , Brady R , Branagan G , Chaudri S , Di Fabio F , Dennison G , Donnelly D , Evans M , Gerald F , Gonzalez S , Grainger J , Hardy A , Husain N , Kapur S , Keogh K , Lim M , Mackey P , Maeda Y , Mangam S , Mazarelo F , Muhammad K , Pawa N , Pearce L , Pitt J , Rajaganeshan R , Shackley P , Simmonds R , Stevenson R , Torkington J , Vaughan-Shaw P , Dale Vimalachandran , Wilson J 
Published: March 2024

Abstract

Background
Numerous surgical approaches exist for the treatment of pilonidal disease. Current literature on treatment is of poor quality, limiting the ability to define optimal intervention. The aim of this study was to provide real-world data on current surgical practice and report patient and risk-adjusted outcomes, informing future trial design.

Methods
This UK-wide multicentre prospective cohort study, including patients (aged over 16 years) who had definitive treatment for symptomatic pilonidal disease, was conducted between May 2019 and March 2022. Patient and disease characteristics, and intervention details were analysed. Data on patient-reported outcomes, including pain, complications, treatment failure, wound issues, and quality of life, were gathered at various time points up to 6 months after surgery. Strategies were implemented to adjust for risk influencing different treatment choices and outcomes.

Results
Of the 667 participants consenting, 574 (86.1%) were followed up to the study end. Twelve interventions were observed. Broadly, 59.5% underwent major excisional surgery and 40.5% minimally invasive surgery. Complications occurred in 45.1% of the cohort. Those who had minimally invasive procedures had better quality of life and, after risk adjustment, less pain (score on day 1: mean difference 1.58, 95% c.i. 1.14 to 2.01), fewer complications (difference 17.5 (95% c.i. 9.1 to 25.9)%), more rapid return to normal activities (mean difference 25.9 (18.4 to 33.4) days) but a rate of higher treatment failure (difference 9.6 (95% c.i. 17.3 to 1.9)%). At study end, 25% reported an unhealed wound and 10% had not returned to normal activities.

Conclusion
The burden after surgery for pilonidal disease is high and treatment failure is common. Minimally invasive techniques may improve outcomes at the expense of a 10% higher risk of treatment failure.