bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclopropyl Building Blocks in Organic Synthesis. Part 143. A Two‐Step, Three‐Component Queuing Cascade Leading to Dihydrobenzoxepine and Dihydrobenzazepine Derivatives.
Authors: Yucel Baris , Valentic Natasa , Noltemeyer Mathias , de Meijere Armin 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Triethylborane: An “Old” Reagent with New Functions. 1,2‐Hydroboration.
Authors: Wrackmeyer Bernd , Khan Ezzat , Bayer Stefan , Shahid Khadija 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Zinc‐Mediated Cleavage of Diselenides: A Novel Synthesis of Selenoformates in Aqueous Media.
Authors: Movassagh Barahman , Fazeli Azadeh 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Constituents of High Altitude Himalayan Herbs. Part 20. A C‐19 Diterpenoid Alkaloid from Aconitum balfourii.
Authors: Khetwal K. S. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient Conversion of Tomatidine into Neuritogenic Pregnane Derivative.
Authors: Matsushita Sayaka , Yanai Yoshihiro , Fusyuku Asami , Fujiwara Yukio , Ikeda Tsuyoshi , Ono Masateru , Han Chunguang , Ojika Makoto , Nohara Toshihiro 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Direct Stereocontrolled Synthesis of 3‐Amino‐3‐deoxy‐β‐Mannopyranosides: Importance of the Nitrogen Protecting Group on Stereoselectivity.
Authors: Crich David , Xu Huadong 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Host—Guest Interactions Involving Cyclodextrins: Useful Complementary Insights Achieved by Polarimetry.
Authors: Meo Paolo Lo , D'Anna Francesca , Riela Serena , Gruttadauria Michelangelo , Noto Renato 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Amphidinolactone B, a New 26‐Membered Macrolide from Dinoflagellate Amphidinium sp.
Authors: Takahashi Yohei , Kubota Takaaki , Kobayashi Jun'ichi 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Design, Synthesis, and Antiangiogenic Effects of a Series of Potent Novel Fumagillin Analogues.
Authors: Lee Hong Woo , Cho Chin Sung , Kang Sung Kwon , Yoo Yong Sang , Shin Jae Soo , Ahn Soon Kil 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Electronic, Magnetic and Transport Properties of Rare‐Earth Monopnictides
Authors: Duan Chun‐Gang , Sabirianov R. F. , Mei W. N. , Dowben P. A. , Jaswal S. S. , Tsymbal E. Y. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Epitaxial Growth and Surface Properties of Half‐Metal NiMnSb Films
Authors: Borca C. N. , Ristoiu D. , Jeong H.‐K. , Komesu Takashi , Caruso A. N. , Pierre J. , Ranno L. , Nozieres J. P. , Dowben P. A. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Zintl Ion[Pb10]2‐: a Rare Example of a Homoatomic Closo Cluster
Authors: Rose Michael J. , Mascharak Pradip K. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Liquid‐Phase Catalytic Processing of Biomass‐Derived Oxygenated Hydrocarbons to Fuels and Chemicals
Authors: Chheda Juben N. , Huber George W. , Dumesic James A. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydrogen Production Reactions from Carbon Feedstocks: Fossil Fuels and Biomass
Authors: Navarro R. M. , Pena M. A. , Fierro J. L. G. 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Determination of Relative Configuration in Organic Compounds by NMR Spectroscopy and Computational Methods
Authors: Bifulco Giuseppe , Dambruoso Paolo , Gomez‐Paloma Luigi , Riccio Raffaele 
Published: November 2007

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase IspE of the Non‐Mevalonate Pathway for Isoprenoid Biosynthesis
Authors: Crane Christine M. , Hirsch Anna K. H. , Alphey Magnus S. , Sgraja Tanja , Lauw Susan , Illarionova Victoria , Rohdich Felix , Eisenreich Wolfgang , Hunter William N. , Bacher Adelbert , Diederich François 
Published: November 2007

AbstractThe enzymes of the non‐mevalonate pathway for isoprenoid biosynthesis are attractive targets for the development of novel drugs against malaria and tuberculosis. This pathway is used exclusively by the corresponding pathogens, but not by humans. A series of water‐soluble, cytidine‐based inhibitors that were originally designed for the fourth enzyme in the pathway, IspD, were shown to inhibit the subsequent enzyme, the kinase IspE (from Escherichia coli). The binding mode of the inhibitors was verified by co‐crystal structure analysis, using Aquifex aeolicus IspE. The crystal structures represent the first reported example of a co‐crystal structure of IspE with a synthetic ligand and confirmed that ligand binding affinity originates mainly from the interactions of the nucleobase moiety in the cytidine binding pocket of the enzyme. In contrast, the appended benzimidazole moieties of the ligands adopt various orientations in the active site and establish only poor intermolecular contacts with the protein. Defined binding sites for sulfate ions and glycerol molecules, components in the crystallization buffer, near the well‐conserved ATP‐binding Gly‐rich loop of IspE were observed. The crystal structures of A. aeolicus IspE nicely complement the one from E. coli IspE for use in structure‐based design, namely by providing invaluable structural information for the design of inhibitors targeting IspE from Mycobacterium tuberculosis and Plasmodium falciparum. Similar to the enzymes from these pathogens, A. aeolicus IspE directs the OH group of a tyrosine residue into a pocket in the active site. In the E. coli enzyme, on the other hand, this pocket is lined by phenylalanine and has a more pronounced hydrophobic character.
Identification of a Peripheral Substitution Symmetry Effect in Self‐Assembled Architectures
Authors: Ma Xiao‐Jing , Yang Yan‐Lian , Deng Ke , Zeng Qing‐Dao , Wang Chen , Zhao Ke‐Qing , Hu Ping , Wang Bi‐Qin 
Published: November 2007

AbstractTwo complementary classes of molecules based on a triphenylene core are synthesized. The two‐dimensional (2D) assemblies of these molecules deposited on a highly oriented pyrolytic graphite (HOPG) surface are identified with scanning tunneling microscopy (STM). Structures with large cavities are formed by symmetric molecules, while uniform and closely packed stripe‐assembled structures are obtained for asymmetric molecules. X‐ray diffraction (XRD) results support the observation of an ordered hexagonal columnar mesophase for symmetric molecules and a rectangular columnar mesophase for asymmetric molecules. The study demonstrates that the substitution symmetry has significant effects on the assembly characteristics of molecular architectures and also on the three‐dimensional (3D) macroscopic properties of the molecular materials.
Ruthenium(II)‐Catalyzed [2+2] Cycloadditions of anti 7‐Substituted Norbornenes
Authors: Jordan Robert W. , Le Marquand Paul , Tam William 
Published: November 2007

AbstractThe ruthenium(II)‐catalyzed [2+2] cycloadditions of anti 7‐substituted norbornenes with an alkyne were investigated. The cycloadditions were found to proceed with a high degree of stereoselectivity, giving only the exo stereoisomers in moderate to good yields using an improved protocol. Comparative rate studies between a variety of anti 7‐substituted norbornenes and an alkyne revealed that the reactivity of the alkene component decreases dramatically as the alkene becomes more electron deficient.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Redox‐Active Catechol‐Functionalized Molecular Rods: Suitable Protection Groups and Single‐Molecule Transport Investigations
Authors: Weibel Nicolas , Błaszczyk Alfred , von Hänisch Carsten , Mayor Marcel , Pobelov Ilya , Wandlowski Thomas , Chen Fang , Tao Nongjian 
Published: November 2007

AbstractThe synthesis of molecular rod 1 comprising a central redox‐active unit and two terminal acetyl‐protected sulfur groups is reported. Various protecting groups for the catechol moiety were investigated and protected precursors 14–18 were synthesized. In particular, ethyl orthoformate 17 can be easily and selectively deprotected in mild acidic conditions ruling out the need for a strong Lewis acid like boron tribromide. The redox activity of 1 was confirmed by cyclic voltammetric investigations. Gold–molecule–gold junctions were formed with the dimethyl‐protected rod 18. Single‐molecule transport investigations using this molecular rod revealed a set of three single‐junction conductance values varying over two orders of magnitude.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Colorectal cancer screening: A comparison of 35 initiatives in 17 countries
Authors: Benson Victoria S. , Patnick Julietta , Davies Anna K. , Nadel Marion R. , Smith Robert A. , Atkin Wendy S. 
Published: November 2007

AbstractAlthough in its infancy, organized screening for colorectal cancer (CRC) in the general population is increasing at regional and national levels. Documenting and describing these initiatives is critical to identifying, sharing and promoting best practice in the delivery of CRC screening. Subsequently, the International Colorectal Cancer Screening Network (ICRCSN) was established in 2003 to promote best practice in the delivery of organized screening programs. The initial aim was to identify and document organized screening initiatives that commenced before May 2004. Each identified initiative was sent 1 questionnaire per screening modality: fecal occult blood test, flexible sigmoidoscopy or total colonoscopy. Information was collected on screening methodology, testing details and initiative status. In total, 35 organized initiatives were identified in 17 countries, including 10 routine population‐based screening programs, 9 pilots and 16 research projects. Fecal occult blood tests were the most frequently used screening modality, and total colonoscopy was seldom used as a primary screening test. The eligible age for screening ranged from 40 years old to no upper limit; most initiatives included participants aged 50 to 64. Recruitment was usually done by a mailed invitation or during a visit to a family physician. In conclusion, this is the first investigation describing the delivery of CRC screening protocols to various populations. The work of the ICRCSN is enabling valuable information to be shared and a common nomenclature to be established. © 2007 Wiley‐Liss, Inc.
On H‐immersions
Authors: Ferrara Michael , Gould Ronald J. , Tansey Gerard , Whalen Thor 
Published: November 2007

AbstractFor a fixed multigraph H, possibly containing loops, with V(H) = {h1,…, hk}, we say a graph G is H‐linked if for every choice of k vertices v1,…,vk in G, there exists a subdivision of H in G such that vi represents hi (for all i). An H‐immersion in G is similar except that the paths in G, playing the role of the edges of H, are only required to be edge disjoint. In this article, we extend the notion of an H‐linked graph by determining minimum degree conditions for a graph G to contain an H‐immersion with a bounded number of vertex repetitions on any choice of k vertices. In particular, we extend results found in [2,3,5]. © 2007 Wiley Periodicals, Inc. J Graph Theory 57: 245–254, 2008
Method development validation for corticoids in animal feed samples by liquid chromatography using a monolithic column
Authors: Muñiz‐Valencia Roberto , Gonzalo‐Lumbreras Raquel , Santos‐Montes Ana , Izquierdo‐Hornillos Roberto 
Published: November 2007

AbstractA LC method for corticosteroids (CC) determination in poultry feed using a Chromolith column and UV detection has been developed and validated. The method development involved the optimization of different hydro‐organic mobile phases using methanol or ACN as organic modifiers, flow rate, and temperature. The optimum separation was achieved at 40°C using ACN/water (21:79 v/v) as mobile phase and 3 mL/min flow rate, allowing the separation to baseline of four out of seven CC in about 10 min. Prior to LC, a sample preparation procedure previously assayed for anabolics was used. It includes a leaching process, saponification of the esters from fatty acids, and SPE. Method validation was carried out according to the EU criteria established for quantitative screening methods. The extraction efficiencies, decision limits (CCα), and detection capabilities (CCβ) for these compounds were in the ranges of 86–92%, 27–36 μg/kg, and 33–43 μg/kg, respectively. The repeatability and the within‐laboratory reproducibility at 1, 1.5, and 2 CCβ concentration levels were smaller than 9.0, 5.0, and 4.2% and 9.4, 6.4, and 4.9%, respectively. The CV values of the robustness test were less than 3.8% and the accuracy was in the range of 98–103%. The proposed method was applied to other feed with satisfactory results.
Monolith‐based immobilized enzyme reactors: Recent developments and applications for proteome analysis
Authors: Ma Junfeng , Zhang Lihua , Liang Zhen , Zhang Weibing , Zhang Yukui 
Published: November 2007

AbstractIn the current proteome study, protein digestion is indispensable before proteins could be identified by MS/MS, no matter based on top–down or bottom–up strategies. Compared to the traditional digestion performed in free solution, immobilized enzyme shows great advantages in digestion speed, stability, and longevity, especially with monolithic materials as the supports. Besides the improved digestion capacity, the immobilized enzyme reactors (IMERs) could be further coupled with the separation and detection systems, enabling high‐throughput protein identification. In this paper, the latest advances in the monolith‐based IMERs and their applications in proteomic study are briefly summarized. By reviewing these achievements, it could be seen that monilith‐based IMERs have very bright future in proteome analysis.
Determination of fluoroquinolone antibiotics in surface waters from Mondego River by high performance liquid chromatography using a monolithic column
Authors: Pena Angelina , Chmielova Daniela , Lino Celeste M. , Solich Petr 
Published: November 2007

AbstractA novel LC–fluorescence detection method based on the use of a monolithic column for the determination of norfloxacin, ciprofloxacin, and enrofloxacin antibiotic residues in environmental waters was developed. Fluoroquinolones (FQs) were isocratically eluted using a mobile phase consisting of 0.025 M phosphoric acid solution at pH 3.0 with tetrabutylammonium and methanol (960:40, v/v) through a Chromolith Performance RP‐18e column (100×4.6 mm) at a flow rate of 2.5 mL/min and detected at excitation and emission wavelengths of 278 and 450 nm, respectively. After acidification and addition of EDTA, water samples were extracted using an Oasis HLB cartridge. Linearity was evaluated in the range of 0.05 to 1 μg/mL and correlation coefficients of 0.9945 for norfloxacin, 0.9974 for ciprofloxacin, and 0.9982 for enrofloxacin were found. The limit of quantification was 25 ng/L for the three FQs. The recovery of FQs spiked into river water samples at 25, 50, and 100 ng/L fortification levels ranged from 76.5 to 91.0% for norfloxacin, 78.5 to 97.2% for ciprofloxacin, and 79.4 to 93.6% for enrofloxacin. This method was successfully applied to the analysis of water samples from the Mondego River, and ciprofloxacin and enrofloxacin residues were detected in eight water samples.
Mass spectrometry analysis of new chemical entities for pharmaceutical discovery
Authors: Fang Annette S. , Miao Xiusheng , Tidswell Peter W. , Towle Marc H. , Goetzinger Wolfgang K. , Kyranos James N. 
Published: November 2007

AbstractIn this Section, we review the applications of mass spectrometry for the analysis and purification of new chemical entities (NCEs) for pharmaceutical discovery. Since the speed of synthesis of NCEs has dramatically increased over the last few years, new high throughput analytical techniques have been developed to keep pace with the synthetic developments. In this Section, we review both novel, as well as modifications of commonly used mass spectrometry techniques that have helped increase the speed of the analytical process. Part of the review is devoted to the purification of NCEs, which has undergone significant development in recent years, and the close integral association between characterization and purification to drive high throughput operations. At the end of the Section, we review potential future directions based on promising and exciting new developments. © 2007 Wiley Periodicals, Inc., Mass Spec Rev 27:20–34, 2008
Insulin‐like growth factor‐1 (IGF‐1) and leucine activate pig myogenic satellite cells through mammalian target of rapamycin (mTOR) pathway
Authors: Han Bing , Tong Junfeng , Zhu Mei J. , Ma Changwei , Du Min 
Published: November 2007

AbstractMyogenic satellite cells are adult stem cells and have important roles in skeletal muscle growth, repair, and regeneration. Both insulin‐like growth factor‐1 (IGF‐1) and leucine stimulate skeletal muscle growth, which link to the activation and proliferation of myogenic satellite cells in skeletal muscle. Mammalian target of rapamycin (mTOR) signaling is one of the main signaling pathways controlling protein synthesis and cell proliferation. Thus, IGF‐1 and leucine may stimulate activation of myogenic satellite cells through mTOR signaling. In this study, myogenic satellite cells were isolated from 6‐month‐old pigs and subjected to IGF‐1 and leucine treatments. Both IGF‐1 and leucine upregulated mTOR signaling in myogenic satellite cells. The phosphorylation of mTOR at Ser2448increased 83.8 ± 7.7% by IGF‐1 (P < 0.05) and 83.4 ± 5.7% by leucine (P < 0.05). The downstream targets of mTOR, S6 kinase, and 4E‐binding protein 1 (4EBP1) were also phosphorylated due to IGF‐1 and leucine treatments. Treatment with IGF‐1 and leucine induced the phosphorylation of tuburin (TSC2), a key mediator upstream of mTOR signaling, by 272.8 ± 26.4% and 94.2 ± 28.7%, respectively. Treatment of cells with both IGF‐1 and leucine did not show synergistic effect on mTOR signaling. Inhibition of mTOR by rapamycin abolished the protein synthesis and cell proliferation stimulated by both IGF‐1 and leucine. In summary, our data showed that in preliminary cultured myogenic satellite cells mTOR signaling was activated due to IGF‐1 and leucine treatments, and this mTOR activation is necessary for the activation of myogenic satellite cells. Mol. Reprod. Dev. 75: 810–817, 2008. © 2007 Wiley‐Liss, Inc.
Five azacytidine, a DNA methyltransferase inhibitor, specifically inhibits testicular cord formation and Sertoli cell differentiation in vitro
Authors: Mizukami Takuo , Kanai Yoshiakira , Fujisawa Masahiko , Kanai‐Azuma Masami , Kurohmaru Masamichi , Hayashi Yoshihiro 
Published: November 2007

AbstractIn mammals, Sry, Sox9, and M33 act as regulators at a chromatin level and promote the maturation of embryonic gonads into testes. Recently, it was shown that transcriptional regulation by DNA methylation plays crucial roles in gene expression during the differentiation and development of various cell types. To determine the involvement of DNA methylation in sex determination of the gonad, we developed and performed organ culture of gonad with the DNA methyltransferase inhibitor 5‐azacytidine to induce global DNA methylation status changes. In vitro treatment with 5‐azacytidine specifically inhibited testicular cord formation in a dose‐dependent manner; however, no appreciable defect was observed in ovarian explants. Inhibition of testicular cord was observed only in gonads from11.5 days post‐coitus embryos. These effects were not observed in 5‐azacytidine‐treated gonads from 12.0 days post‐coitus embryos. To determine the effect of 5‐azacytidine on Sertoli and Leydig cell differentiation in the testis, we performed whole mount in situ hybridization analysis. The Leydig and stromal cell marker genes Lhx9, Mfge8, and 3β‐Hsd were normally induced in 5‐azaytidine‐treated testicular explants. Sertoli cell marker genes, Sox9 and MIS were normally induced, but Col9a3, encoding an extracellular matrix component, was inhibited in 5‐azacytidine‐treated testicular explants. Thus, our data show that DNA methylation is involved in testicular cord formation and Sertoli cell differentiation, acting directly on the gonad at 11.5 days post‐coitus. Mol. Reprod. Dev. 75: 1002–1010, 2007. © 2007 Wiley‐Liss, Inc.