bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling the Hidden Threat: Drought‐Induced Inelastic Subsidence in Expansive Soils
Authors: Welch Jennifer , Wang Guoquan , Bao Yan , Zhang Shuangcheng , Huang Guanwen , Hu Xie 
Published: March 2024

AbstractExpansive soils pose a significant challenge in geotechnical engineering, especially in coastal areas. While research has mainly focused on their elastic properties, this study explores the overlooked aspect of inelastic subsidence during prolonged droughts, utilizing decade‐long GPS datasets from the University of Houston Coastal Center. Our findings reveal substantial subsidence, approximately one to two dm, during the summer droughts of 2018, 2020, 2022, and 2023, due to compaction within the upper 4 m of expansive soils. Inelastic subsidence constitutes roughly 10% of the total subsidence, resulting in step‐like permanent land elevation loss over time. Notably, drought‐induced subsidence is prominent in open‐field areas with expansive soils but is minor in built‐up areas or in non‐expansive soil regions. The occurrence of inelastic subsidence challenges traditional assessments of relative sea‐level rise and coastal flooding, emphasizing the need to consider it in coastal infrastructure planning for enhanced resilience against climate uncertainties.
Deformation, Strength and Tectonic Evolution of Basal Ice in Taylor Glacier, Antarctica
Authors: Fitzsimons Sean , Samyn Denis , Lorrain Regi 
Published: March 2024

AbstractObservation and measurements of ice structure and deformation made in tunnels excavated into the margin of Taylor Glacier, a polythermal glacier in the McMurdo Dry Valleys of Antarctica, reveal a complex, rapidly deforming basal ice sequence. Displacement measurements in the basal ice, which is at a temperature of −18°C, together with the occurrence of cavities and slickenslides, suggest that sliding or rapid deformation in thin zones of high shear occurs at structural discontinuities within the basal zone. Strain measurements show that the highest strain rates occur in ice with average debris concentrations of 26% followed by ice with debris concentrations of around 12%. The lowest strain rates occur in clean bubbly ice that has very low debris concentrations (<0.02%). Deformation within the basal ice sequence is dominated by simple shear but disrupted by folding which results in shortening of the debris‐bearing ice followed by attenuation of the folds due to progressive simple shear which generates predominantly laminar basal ice structures. About 60% of glacier surface velocity can be attributed to deformation within the 4.5 m thick sequence of basal ice that was monitored for this study, and 15% of motion can be attributed to sliding or very localized shear. The combination of high debris concentrations and high strain rates in the debris‐bearing ice results in high rates of abrasion and the production of striated and facetted clasts typical of temperate glaciers, even though the basal ice is at a temperature of −18°C.
Geoelectric Field Estimations During Geomagnetic Storm in North China From SinoProbe Magnetotelluric Impedances
Authors: Shao Qihe , Liu Ying , Luo Yinhe , Heinson Graham , Xu Yixian , Du Jinsong , Chen Chao 
Published: March 2024

AbstractEvaluating the impact of geomagnetic disturbances on power grid infrastructure is critical to mitigate the risk posed by geomagnetically induced currents (GICs). In this paper, the geoelectric field and induced voltage distribution in North China were estimated from the SinoProbe magnetotelluric (MT) impedance data together with the geomagnetic observatory data of six INTERMAGNET stations recorded during the significant geomagnetic storm of 17th March 2015. The measured impedances from 119 SinoProbe MT sites were convolved with geomagnetic observatory data to account for the Earth's complex three‐dimensional electrical resistivity structure. The resultant geoelectric field was then used to model the induced voltage distribution across the regional power transmission network in North China. Due to the large inter‐site distances of the SinoProbe MT program, the derived geoelectric field is mostly homogeneous, except in the Ordos Basin that displays a polarization of the geoelectric field, and with higher magnitudes in the orogenic belts. The estimated geoelectric fields in Taihang‐Lvliang, Yanshan, and Luxi orogenic belts of North China were large (>1 V/km) during the storm, due to high‐resistivity lithosphere resulting in large voltage gradients in the Earth. However, in relation to locations of major power transmission lines, only the central part of North China experienced induced voltages exceeding 100 V.
Age, Kinematic and Thermal Constraints of Syn‐Orogenic Low‐Temperature Deformation Events: Insights From Thermochronology and Structural Data of the Nekézseny Thrust (Alpine‐Carpathian‐Dinaric Area)
Authors: Oravecz Éva , Benkó Zsolt , Arató Róbert , Dunkl István , Héja Gábor , Kövér Szilvia , Németh Tibor , Fodor László 
Published: March 2024

AbstractUnraveling the age and kinematics of low temperature deformation events is crucial in understanding the late‐stage evolution of orogens. However, accurate age constraints can often be challenging to obtain due to unideal outcrop conditions, large sedimentary hiatuses or the lack of well‐defined thermal events. In this study, we show on the example of the Nekézseny Thrust, a poorly exposed late orogenic thrust in the southern Western Carpathians, that a combined approach of structural analysis and multi‐method thermochronology can provide the necessary temporal, kinematic and thermal constraints for a detailed reconstruction of the deformation history. While structural mapping revealed that the Late Cretaceous Uppony Gosau Basin in the footwall of the Nekézseny Thrust underwent a significant post‐Campanian and pre‐Miocene shortening, K/Ar dating of fault gouge samples from the main fault zone constrained the primary thrusting event to the Maastrichtian. Based on the acquired apatite fission‐track and (U‐Th)/He ages, subsequent heating of the Upper Cretaceous sediments due to tectonic burial was limited to 75–100°C, followed by deformation‐related and gradual cooling between the Eocene and Early Miocene. Considering the reconstructed deformation history, as well as the large‐scale tectonic affinity of the displaced units in its footwall and hanging wall, the Nekézseny Thrust is a far‐traveled (ca. 600 km) segment of the Late Cretaceous Alps‐Dinarides contact zone, whose development was linked to the switch from lower plate to upper plate position with respect to the Sava Zone and Alpine Tethys sutures, respectively.
The two sides of chromosomal instability: drivers and brakes in cancer
Authors: Hosea Rendy , Hillary Sharon , Naqvi Sumera , Wu Shourong , Kasim Vivi 
Published: March 2024

AbstractChromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities, including deviations from the normal chromosome number or structural changes in chromosomes. CIN arises from errors in DNA replication and chromosome segregation during cell division, leading to the formation of cells with abnormal number and/or structure of chromosomes. Errors in DNA replication result from abnormal replication licensing as well as replication stress, such as double-strand breaks and stalled replication forks; meanwhile, errors in chromosome segregation stem from defects in chromosome segregation machinery, including centrosome amplification, erroneous microtubule–kinetochore attachments, spindle assembly checkpoint, or defective sister chromatids cohesion. In normal cells, CIN is deleterious and is associated with DNA damage, proteotoxic stress, metabolic alteration, cell cycle arrest, and senescence. Paradoxically, despite these negative consequences, CIN is one of the hallmarks of cancer found in over 90% of solid tumors and in blood cancers. Furthermore, CIN could endow tumors with enhanced adaptation capabilities due to increased intratumor heterogeneity, thereby facilitating adaptive resistance to therapies; however, excessive CIN could induce tumor cells death, leading to the “just-right” model for CIN in tumors. Elucidating the complex nature of CIN is crucial for understanding the dynamics of tumorigenesis and for developing effective anti-tumor treatments. This review provides an overview of causes and consequences of CIN, as well as the paradox of CIN, a phenomenon that continues to perplex researchers. Finally, this review explores the potential of CIN-based anti-tumor therapy.
Trajectories in depressive symptoms and midlife brain health
Authors: Dintica Christina S. , Habes Mohamad , Schreiner Pamela J. , Launer Lenore J. , Yaffe Kristine 
Published: March 2024

AbstractDepressive symptoms may either be a risk factor or prodromal to dementia. Investigating this association in midlife may help clarify the role of depression in cognitive aging. We aimed to identify trajectories in depressive symptoms in early to mid-life and related cognitive and brain outcomes in midlife. This study includes 3944 Black and White participants (ages 26−45 years at baseline) from the Coronary Artery Risk Development in Young Adults (CARDIA) study with 20 years of follow-up. Depressive symptoms were assessed using the Center for Epidemiological Studies Depression scale at five time points over 20 years. Growth mixture modeling (GMM) was used to identify depressive symptom trajectories. Participants completed a neuropsychological battery 20 years after baseline, including the Digit Symbol Substitution Test (DSST), Rey-Auditory Verbal Learning Test (RAVLT), Stroop Test, Montreal Cognitive Assessment (MoCA), and category and letter fluency tests. A sub-sample of participants (n = 662) underwent brain magnetic resonance imaging (MRI) to characterize gray matter volumes and white matter hyperintensities (WMHs). We identified four classes of depressive symptom trajectories: a “declining” class (n = 286, 7.3%) with initially high symptoms and subsequent decline, a class with consistently high symptoms (“steady high”; n = 264, 6.7%), a class with late increases in symptoms (“increasing”; n = 277, 7%), and a class with consistently low symptoms (“steady low”; n = 3117, 79.0%). The steady high and the increasing classes had poorer performance on all cognitive tests, while the declining class had poorer performance on the DSST, verbal fluency, and MoCA. Compared to the steady low symptom class, the steady high class had lower volumes in the entorhinal cortex (β: −180.80, 95% CI: −336.69 to −24.91) and the amygdala (β: −40.97, 95% CI: −74.09 to −7.85), the increasing class had more WMHs (β: 0.55, 95% CI: 0.22 to 0.89), and the declining class was not significantly different in any brain measures. Trajectories in depressive symptoms in young to mid-adulthood show distinct cognitive and brain phenotypes in midlife. Steady high depressive symptoms may represent a group that is at risk for dementia, whereas increasing symptoms in midlife may be associated with white matter damage.
Identification of MYCN non-amplified neuroblastoma subgroups points towards molecular signatures for precision prognosis and therapy stratification
Authors: Hu Xiaoxiao , Zhou Yilu , Hill Charlotte , Chen Kai , Cheng Cheng , Liu Xiaowei , Duan Peiwen , Gu Yaoyao , Wu Yeming , Ewing Rob M. , Li Zhongrong , Wu Zhixiang , Wang Yihua 
Published: March 2024

Abstract
Background
Despite the extensive study of MYCN-amplified neuroblastomas, there is a significant unmet clinical need in MYCN non-amplified cases. In particular, the extent of heterogeneity within the MYCN non-amplified population is unknown.

Methods
A total of 1566 samples from 16 datasets were identified in Gene Expression Omnibus (GEO) and ArrayExpress. Characterisation of the subtypes was analysed by ConsensusClusterPlus. Independent predictors for subgrouping were constructed from the single sample predictor based on the multiclassPairs package. Findings were verified using immunohistochemistry and CIBERSORTx analysis.

Results
We demonstrate that MYCN non-amplified neuroblastomas are heterogeneous and can be classified into 3 subgroups based on their transcriptional signatures. Within these groups, subgroup_2 has the worst prognosis and this group shows a ‘MYCN’ signature that is potentially induced by the overexpression of Aurora Kinase A (AURKA); whilst subgroup_3 is characterised by an ‘inflamed’ gene signature. The clinical implications of this subtype classification are significant, as each subtype demonstrates a unique prognosis and vulnerability to investigational therapies. A total of 420 genes were identified as independent subgroup predictors with average balanced accuracy of 0.93 and 0.84 for train and test datasets, respectively.

Conclusion
We propose that transcriptional subtyping may enhance precision prognosis and therapy stratification for patients with MYCN non-amplified neuroblastomas.
Gemcitabine elaidate and ONC201 combination therapy for inhibiting pancreatic cancer in a KRAS mutated syngeneic mouse model
Authors: Kumar Virender , Sethi Bharti , Staller Dalton W. , Shrestha Prakash , Mahato Ram I. 
Published: March 2024

AbstractApproximately 90% of pancreatic cancer (PC) contain KRAS mutations. Mutated KRAS activates the downstream oncogenic PI3K/AKT and MEK signaling pathways and induces drug resistance. However, targeting both pathways with different drugs can also lead to excessive toxicity. ONC201 is a dual PI3K/AKT and MEK pathway inhibitor with an excellent safety profile that targets death receptor 5 (DR5) to induce apoptosis. Gemcitabine (GEM) is a first-line chemotherapy in PC, but it is metabolically unstable and can be stabilized by a prodrug approach. In this study, phospho-Akt, phospho-mTOR, and phospho-ERK protein expressions were evaluated in patient PDAC-tissues (n = 10). We used lipid-gemcitabine (L_GEM) conjugate, which is more stable and enters the cells by passive diffusion. Further, we evaluated the efficacy of L_GEM and ONC201 in PC cells and “KrasLSL-G12D; p53LoxP; Pdx1-CreER (KPC) triple mutant xenograft tumor-bearing mice. PDAC patient tissues showed significantly higher levels of p-AKT (Ser473), p-ERK (T202/T204), and p-mTOR compared to surrounding non-cancerous tissues. ONC201 in combination with L_GEM, showed a superior inhibitory effect on the growth of MIA PaCa-2 cells. In our in-vivo study, we found that ONC201 and L_GEM combination prevented neoplastic proliferation via AKT/ERK blockade to overcome chemoresistance and increased T-cell tumor surveillance. Simultaneous inhibition of the PI3K/AKT and MEK pathways with ONC201 is an attractive approach to potentiate the effect of GEM. Our findings provide insight into rational-directed precision chemo and immunotherapy therapy in PDAC.
Bayesian optimization-driven enhancement of the thermoelectric properties of polycrystalline III-V semiconductor thin films
Authors: Ishiyama Takamitsu , Nozawa Koki , Nishida Takeshi , Suemasu Takashi , Toko Kaoru 
Published: March 2024

Abstract
Studying the properties of thermoelectric materials needs substantial effort owing to the interplay of the trade-off relationships among the influential parameters. In view of this issue, artificial intelligence has recently been used to investigate and optimize thermoelectric materials. Here, we used Bayesian optimization to improve the thermoelectric properties of multicomponent III–V materials; this domain warrants comprehensive investigation due to the need to simultaneously control multiple parameters. We designated the figure of merit ZT as the objective function to improve and search for a five-dimensional space comprising the composition of InGaAsSb thin films, dopant concentration, and film-deposition temperatures. After six Bayesian optimization cycles, ZT exhibited an approximately threefold improvement compared to its values obtained in the random initial experimental trials. Additional analysis employing Gaussian process regression elucidated that a high In composition and low substrate temperature were particularly effective at increasing ZT. The optimal substrate temperature (205 °C) demonstrated the potential for depositing InGaAsSb thermoelectric thin films onto plastic substrates. These findings not only promote the development of thermoelectric devices based on III–V semiconductors but also highlight the effectiveness of using Bayesian optimization for multicomponent materials.
Microinterfaces in biopolymer-based bicontinuous hydrogels guide rapid 3D cell migration
Authors: Xu Karen L. , Di Caprio Nikolas , Fallahi Hooman , Dehghany Mohammad , Davidson Matthew D. , Laforest Lorielle , Cheung Brian C. H. , Zhang Yuqi , Wu Mingming , Shenoy Vivek , Han Lin , Mauck Robert L. , Burdick Jason A. 
Published: March 2024

AbstractCell migration is critical for tissue development and regeneration but requires extracellular environments that are conducive to motion. Cells may actively generate migratory routes in vivo by degrading or remodeling their environments or instead utilize existing extracellular matrix microstructures or microtracks as innate pathways for migration. While hydrogels in general are valuable tools for probing the extracellular regulators of 3-dimensional migration, few recapitulate these natural migration paths. Here, we develop a biopolymer-based bicontinuous hydrogel system that comprises a covalent hydrogel of enzymatically crosslinked gelatin and a physical hydrogel of guest and host moieties bonded to hyaluronic acid. Bicontinuous hydrogels form through controlled solution immiscibility, and their continuous subdomains and high micro-interfacial surface area enable rapid 3D migration, particularly when compared to homogeneous hydrogels. Migratory behavior is mesenchymal in nature and regulated by biochemical and biophysical signals from the hydrogel, which is shown across various cell types and physiologically relevant contexts (e.g., cell spheroids, ex vivo tissues, in vivo tissues). Our findings introduce a design that leverages important local interfaces to guide rapid cell migration.
Transient expression of the neuropeptide galanin modulates peripheral‑to‑central connectivity in the somatosensory thalamus during whisker development in mice
Authors: Hevesi Zsofia , Bakker Joanne , Tretiakov Evgenii O. , Adori Csaba , Raabgrund Anika , Barde Swapnali S. , Caramia Martino , Krausgruber Thomas , Ladstätter Sabrina , Bock Christoph , Hökfelt Tomas , Harkany Tibor 
Published: March 2024

AbstractThe significance of transient neuropeptide expression during postnatal brain development is unknown. Here, we show that galanin expression in the ventrobasal thalamus of infant mice coincides with whisker map development and modulates subcortical circuit wiring. Time-resolved neuroanatomy and single-nucleus RNA-seq identified complementary galanin (Gal) and galanin receptor 1 (Galr1) expression in the ventrobasal thalamus and the principal sensory nucleus of the trigeminal nerve (Pr5), respectively. Somatodendritic galanin release from the ventrobasal thalamus was time-locked to the first postnatal week, when Gal1R+ Pr5 afferents form glutamatergic (Slc17a6+) synapses for the topographical whisker map to emerge. RNAi-mediated silencing of galanin expression disrupted glutamatergic synaptogenesis, which manifested as impaired whisker-dependent exploratory behaviors in infant mice, with behavioral abnormalities enduring into adulthood. Pharmacological probing of receptor selectivity in vivo corroborated that target recognition and synaptogenesis in the thalamus, at least in part, are reliant on agonist-induced Gal1R activation in inbound excitatory axons. Overall, we suggest a neuropeptide-dependent developmental mechanism to contribute to the topographical specification of a fundamental sensory neurocircuit in mice.
Secondary bone marrow graft loss after third-party virus-specific T cell infusion: Case report of a rare complication
Authors: Keller Michael D. , Schattgen Stefan A. , Chandrakasan Shanmuganathan , Allen E. Kaitlynn , Jensen-Wachspress Mariah A. , Lazarski Christopher A. , Qayed Muna , Lang Haili , Hanley Patrick J. , Tanna Jay , Pai Sung-Yun , Parikh Suhag , Berger Seth I. , Gottschalk Stephen , Pulsipher Michael A. , Thomas Paul G. , Bollard Catherine M. 
Published: March 2024

AbstractVirus-specific T cells (VST) from partially-HLA matched donors have been effective for treatment of refractory viral infections in immunocompromised patients in prior studies with a good safety profile, but rare adverse events have been described. Here we describe a unique and severe adverse event of VST therapy in an infant with severe combined immunodeficiency, who receives, as part of a clinical trial (NCT03475212), third party VSTs for treating cytomegalovirus viremia following bone marrow transplantation. At one-month post-VST infusion, rejection of graft and reversal of chimerism is observed, as is an expansion of T cells exclusively from the VST donor. Single-cell gene expression and T cell receptor profiling demonstrate a narrow repertoire of predominantly activated CD4+ T cells in the recipient at the time of rejection, with the repertoire overlapping more with that of peripheral blood from VST donor than the infused VST product. This case thus demonstrates a rare but serious side effect of VST therapy.
Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation
Authors: Speaks Samuel , McFadden Matthew I. , Zani Ashley , Solstad Abigail , Leumi Steve , Roettger Jack E. , Kenney Adam D. , Bone Hannah , Zhang Lizhi , Denz Parker J. , Eddy Adrian C. , Amer Amal O. , Robinson Richard T. , Cai Chuanxi , Ma Jianjie , Hemann Emily A. , Forero Adriana , Yount Jacob S. 
Published: March 2024

AbstractInfluenza virus activates cellular inflammasome pathways, which can be both beneficial and detrimental to infection outcomes. Here, we investigate the function of the inflammasome-activated, pore-forming protein gasdermin D (GSDMD) during infection. Ablation of GSDMD in knockout (KO) mice (Gsdmd−/−) significantly attenuates influenza virus-induced weight loss, lung dysfunction, lung histopathology, and mortality compared with wild type (WT) mice, despite similar viral loads. Infected Gsdmd−/− mice exhibit decreased inflammatory gene signatures shown by lung transcriptomics. Among these, diminished neutrophil gene activation signatures are corroborated by decreased detection of neutrophil elastase and myeloperoxidase in KO mouse lungs. Indeed, directly infected neutrophils are observed in vivo and infection of neutrophils in vitro induces release of DNA and tissue-damaging enzymes that is largely dependent on GSDMD. Neutrophil depletion in infected WT mice recapitulates the reductions in mortality, lung inflammation, and lung dysfunction observed in Gsdmd−/− animals, while depletion does not have additive protective effects in Gsdmd−/− mice. These findings implicate a function for GSDMD in promoting lung neutrophil responses that amplify influenza virus-induced inflammation and pathogenesis. Targeting the GSDMD/neutrophil axis may provide a therapeutic avenue for treating severe influenza.