bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug survival and adherence to biologic agents in patients with inflammatory bowel disease from a large health maintenance organization
Authors: Rosenberg Vered , Chodick Gabriel , Faccin Freddy , Kariv Revital 
Published: April 2024

Abstract
Background
With the increasing use of biologic therapies for the management of inflammatory bowel disease (IBD), it is important to understand their real-world persistence and adherence rates.
Aims
To assess adherence, drug survival, and risk for discontinuation with biologics in a large cohort of patients with Crohn's disease (CD) and ulcerative colitis (UC)
Methods
Adult biologic treatment-naive and treatment-experienced patients with CD and UC who initiated treatment with a biologic drug or tofacitinib during 2015–2017 with a large, state-mandated healthcare provider in Israel were included. Adherence and discontinuation rates were recorded. Risk for discontinuation was estimated using the Cox proportional hazard model.
Results
A total of 889 patients with CD (44.2% female; mean [SD] age, 36.9 [14.2] years; 73.0% biologic-naive) and 255 patients with UC (52.9% female, mean [SD] age, 41.3 [15.6] years; 71.8% biologic-naive) were included. Among patients with CD and UC receiving their first biologic, high adherence was calculated in 75.7% and 80.3%, respectively. Over the course of one year of follow-up, 32.1% of patients with CD and 37.0% of patients with UC discontinued their biologic therapy. In UC, patients receiving vedolizumab were less likely to discontinue treatment compared with those receiving adalimumab, whereas in CD, both treatments were at similar risk for discontinuation.
Conclusions
Although drug adherence was satisfactory, persistence rates for patients with IBD receiving biologics were suboptimal and varied based on disease, treatment episode, and treatment received.
A Molecular Docking Study between Heavy Metals and Hydrophilic Hsp70 Protein to Explore Binding Pockets
Authors: Mitra Pritish , Singha Sourav , Roy Payel , Saha Deblina , Chatterjee Sabyasachi 
Published: April 2024

Abstract
Microorganisms are abundant resident of whole biosphere and exert influential activity on various numerous biological phenomena. Sources of heavy metal contaminants include refineries, effluent outfalls from factories, waste treatment facilities and different anthropogenic products. Heavy metal pollution is now getting a prime concern for whole world including India also. For example, increased levels of lead, cadmiumfound in river ecosystem of West Bengal. The non-essential minerals cadmium (Cd), lead (Pb)linkedwith damageof vital organs. Remediation of pollutant is required to clean up society. Bioremediation includes use of biological agents such as bacteria are an essential component in the removal process of the contaminants. It is demonstrated that thermophilic bacteria secrete some special protein like heat shock protein to inhale such stress condition. Microbial Hsp70 (DnaK) proteins function to degrade noxious chemicals including heavy metals. Archaeal and bacterial Hsp70 proteins were retrieved and named as BHSP70 to explore and analyze. Three-dimensional structure and quality of protein was predicted and validated. BHSP70-114 of Sulfobacillus acidophilus was selected for metal docking study to visualize their multi-metal resistance capabilities. Best docked model of Hsp70 protein with heavy metals was evaluated with PyMolto inspect the intramolecular interaction. In this in silicostudy, few recognized key amino acid residues like Asp, Asn, Glu, Gln, His, Ser, Cys, Ala were identified, involve in heavy metal (Cd, Pb) binding. Recent approach also provides an important basis to inspect protein engineering for optimum use of bacterial Hsp70 protein to reduce or remove heavy metals from biosphere.
Nutritional composition, chemical profile and antioxidant potential of black puçá fruit (Mouriri pusa) as a strategy for valuing native Brazilian fruits
Authors: Silva Romilda Ramos , Leal Gabriela Fonseca , Gomes Camila Costa , Oliveira José Eduardo Bento , Soares Camila Mariane da Silva , Morais Rômulo Alves , Martins Glêndara Aparecida de Souza 
Published: April 2024

Abstract
The black puçá (Mouriri Pusa) is an unconventional fruit from the Cerrado region of Brazil, commonly known as jabuticaba of forest. However, data on its nutritional composition phytochemical composition are limited. In this study, the nutritional composition, physicochemical characteristics, profile of carbohydrates and organic acids, phenolics and flavonoids individual, amino acids composition, bioactive substances, and antioxidant potential were investigated in the pulp, peel, and seed fractions of puçá-preto. The results confirm that puçá-preto is an important nutritional source. The main organic acids were malic acid (187.54 − 290.50 mg g−1) followed by tartaric acid (57.89 − 134.79 mg g−1). 8 of the 9 essential amino acids were determined in black puçá, with arginine acid (0.24 – 2.03 g 100 g−1) being the majority, followed by glutamic acid (0.34 – 1.87 g 100 g−1). It presented satisfactory results for vitamin C, carotenoids, and anthocyanins, demonstrating potential for pigment extraction. The pulp and peel showed good antioxidant activity in relation to the capture of free radicals by the DPPH method and the reduction of ferric ions in the pulp. In regard to individual phenolic compounds, quercetin was the major compound in the pulp fraction (4.69 µg mL−1); on the other hand, kaempferol had greater expression in the peels (20.78 µg mL−1), while myricetin was quantified only in the seeds (10.67 µg mL−1). The results showed that buritirana is rich in nutrients and bioactive products and can be fully utilized. The products resulting from buritirana processing can be applied in the food, and pharmaceutical industries.
DFT study of electron donor-acceptor (EDA) complexes of 1H-indole and benzyl bromide derivatives: mechanism exploration and theoretical prediction
Authors: Liu Zhao , Wang Shutao , Liu Zhiqiang , Ding Yating , Hu Yansong , Liu Runzhang , Zhang Zhengze , Lei Junqiang 
Published: April 2024

Abstract
Organic synthesis methods initiated by visible light have received increasing attention from synthetic chemists. Reactions initiated by EDA complexes do not require the use of toxic or expensive photoredox catalysts compared to traditional photoreaction processes. However, this kind of reaction requires the structure of the substrate, so it is important to study the detailed and systematic reaction mechanism for its design. The EDA complexes of substituted 1 H-indole and substituted benzyl bromide derivatives were studied by density functional theory (DFT). The difference between EDA complexes with substituents of different kinds and locations were compared by theoretical study and new EDA complex was predicted.
From Thessaloniki to Selânik: the long continuity of urban ceramic production in the Balkans and the Eastern Mediterranean
Authors: Živković Jelena , Raptis Konstantinos T. , Slambeas Periklis 
Published: April 2024

Abstract

Ceramics of Late Byzantine and Ottoman Thessaloniki (the 13th-19th centuries) were studied with archaeological and scientific methods aiming to characterise the ceramic production in this major city of the Balkans and the Eastern Mediterranean. The paper explored the impact that the Ottoman conquest, migrations and socio-economic changes in the city have had on the ceramic production technology. With this aim, common pottery and tobacco pipes excavated at the site of Hamza Bey Mosque, located in the centre of historical Thessaloniki, were subjected to macroscopic, petrographic and chemical analyses. The integrated results contributed to the identification of several urban potting traditions that can be associated with distinct workshops. The production of glazed tableware is characterised by the long technological continuity, spanning between the 13th and 19th centuries, despite frequent changes of decorative styles that followed consumption trends. This continuity is visible in all production sequences, from the procurement of raw materials to the application of high-lead glazes. In addition, another two potting traditions of the Ottoman period introduced technological diversity that could reflect the socio-economic complexity of Thessaloniki between the 15th and 19th centuries.
In silico comparison of apigenin and related compounds with diverse pharmacological activities using AutoDock 4.2.6
Authors: Peanlikhit Tanat , Aryal Uma , Welsh James , Shroyer Kenneth , Rithidech Kanokporn 
Published: April 2024

Abstract
In recent years, molecular docking has been used to predict the binding affinity and interaction between flavonoids (ligands) and specific protein targets (receptors). However, existing studies have focused on a limited number of flavonoids with a small number of targeted proteins. In this study, on the other hand, we used the AutoDock 4.2.6 molecular docking software to compare the binding energy values and interactions of apigenin and 15 flavonoids with 24 different proteins known to be associated with oxidative stress, inflammation, carcinogenesis, and bacterial infections. This comparison will be important for the development of flavonoid-based drugs, allowing for the optimization of flavonoid drugs to better interact with their target proteins alone or in combination with conventional drugs. We used three-dimensional crystal structures of the receptors to identify the amino acids in the active site for docking purposes. Our goal was to identify potential inhibitors of these proteins and understand the structural configurations of flavonoids that affect their binding energy (binding affinity or inhibitory effects). We found that apigenin was a highly effective inhibitor for all tested proteins, with the highest binding energy of -8.21 kcal/mol with p38 mitogen-activated protein kinases and the lowest binding energy of -5.34 kcal/mol with cyclin-dependent kinase 4. In fact, apigenin and most of the tested flavonoids were better inhibitors for xanthine oxidase or DNA methyltransferase than known inhibitors. Our results also suggest that apigenin and selected flavonoids could be used to inhibit the oncogenic activity of KRAS mutations at codon 12 (i.e., G12C, G12D, and G12V) frequently found in solid tumors since they possess high binding energies with these mutated proteins. This finding offers an advantage over targeted therapy drugs that focus on specific KRAS mutations. Furthermore, most flavonoids have good safety profiles, so our resulting data are crucial for developing flavonoid-based drugs and present new insights into developing effective treatments that can attenuate the resistance and side effects of chemotherapy.
The simplified quantum circuits for implementing quantum teleportation
Authors: Zhang Wen-Xiu , Song Guo-Zhu , Wei Hai-Rui 
Published: April 2024

Abstract

It is crucial to design quantum circuits as small as possible and as shallow as possible for quantum information processing tasks. We design quantum circuits with simplified gate-count, cost, and depth for implementing quantum teleportation among various entangled channels. Here the gate-count/cost/depth of the Greenberger-Horne-Zeilinger-based quantum teleportation is reduced from 10/6/8 to 9/4/6, the two-qubit-cluster-based quantum teleportation is reduced from 9/4/5 to 6/3/5, the three-qubit-cluster-based quantum teleportation is reduced from 12/6/7 to 8/4/5, the Brown-based quantum teleportation is reduced from 25/15/17 to 18/8/7, the Borras-based quantum teleportation is reduced from 36/25/20 to 15/8/11, and the entanglement-swapping-based quantum teleportation is reduced from 13/8/8 to 10/5/5. Note that, no feed-forward recover operation is required in the simplified schemes. Moreover, the experimentally demonstrations on IBM quantum computer indicate that our simplified and compressed schemes can be realized with good fidelity.
Assessment of Human Resource for Eye Health Services in Southern Ethiopia.
Authors: MEHARI ZELALEM , Nariani Ashiyana 
Published: April 2024

Abstract
Background
Human resources in eye health are critical to significant reductions in blindness and low vision on a global and regional scale. Blindness and visual impairment affect the quality of life, poverty rates, and employment and educational opportunities of people with visual impairment. This study aimed to assess the availability and distribution of human resources for eye care to determine gaps in eliminating preventable and treatable blindness.
Methods
The study was a descriptive cross-sectional study. Data was collected on the type and number of eye care professionals and their distribution from all government, private, and NGO/Mission eye care facilities in the two regions.
Result
Out of the 77 public hospitals and 642 public health centers, only 39 (5.4%) have been provided eye care services. A total of 48 facilities were provided with eye care services, each of which served 388,765 populations in two regions. Thirty-nine (81.3%) were government-owned, 5 (10.4%) were private for-profit, and 4 (8.3%) were NGO/Mission owned. In these facilities, a total of 217 eye care professionals were practicing: of these, 30 were ophthalmologists, 10 cataract surgeons, 93 optometrists, 62 ophthalmic nurses, 6 ophthalmic officers, one low vision specialist, and 15 optical technicians. The mean number of cataract operations performed per unit was 860 (Range: 30–2,800). The CSR of the SNNPR and Sidama regions was 1086 operations/ million population/year in 2022. From all level eye care centers in the study area, 50% provided cataract surgery services, 19% provided glaucoma surgery services, and 90% provided refraction services. Only one facility had pan-retinal photocoagulation (PRP) and Intravitreal injection services. However, none of the facilities provided a vitro-retinal surgery service.
Conclusion
The human resource for eye care in southern Ethiopia must be improved, falling far below the numbers required by the World Health Organization (WHO) and the IAPB Africa Strategic Plan. Eye care professionals need to be better distributed, as there is a severe shortage of ophthalmic professionals in rural regions. Most of the human resources for the eye health workforce in the area are located in urban cities.
Production of chloroauric acid from electronic waste in salt solution by AC electrolysis
Authors: Yoshizawa Miku , Suda Chihiro , Mori Yuika , Ueda Masaki , Aoshika Kei , Oya Kei , Takami Tomohide 
Published: April 2024

Abstract
Extraction of gold from electronic waste were commonly conducted using aqua regia. Here, we have shown a method to produce chloroauric acid in salt solution by bipolar AC electrolysis. The developed bipolar AC electrolysis method provides an environment-friendly process to extract gold from electronic waste containing gold without using any strong acids such as aqua regia.
Relationship between internal and external training load metrics on neuromuscular performance
Authors: Collins James J. , Malone Shane , Collins Kieran D. 
Published: April 2024

Abstract
The study investigates the association between internal and external training load on neuromuscular performance (NMP) on elite soccer players. Thirty-five professional soccer players from a single squad participated in the study. Players performed a countermovement jump as a surrogate measure of NMP. Tests were conducted the day prior to a game. Internal load was measured using session rating of perceived exertion, with external load analysed through 10 Hz GPS units. Measures of external load included total distance, high-speed running, sprint distance, accelerations and decelerations. Measures of NMP were RSI-mod, time to take off (TTTO) and jump height (JH). Within a 7-day training window, total distance (ES = 0.03) and acceleration (ES = 0.04) had a significant interaction with NMP. Within a 14-day training window, RSI-mod and TTTO had a significant interaction with internal load (ES = 0.01; ES = 1.54) and high-speed running (ES = 0.02; ES = 1.44), JH and total distance had a significant interaction (ES = 1.867). For the 28-day training window, JH and sprint distance had a significant interaction (ES = 1.86). Practitioners should use a multi-metric approach with measures of NMP and loading to gain a greater understanding of their athletes.
Isoliquiritigenin induced endoplasmic reticulum stress in zebrafish embryos
Authors: Hu Deliang , Xia Yang , Zhang Chun , Fan Shijie , Lin Ling , Luo Puying , Xiong Yuanhuan , Su Yufang 
Published: April 2024

Abstract
Isoliquiritigenin (ISL), a natural flavonoid compound from the root of licorice, has antioxidant, anticancer, anti-inflammatory, and anti-allergic effects, and is commonly detected in both environmental and human samples. Our previous studies have demonstrated that exposure to ISL can result in developmental deformities and abnormal immune responses. However, the molecular mechanism underlying the toxicity of ISL towards zebrafish embryos remains incompletely understood. Therefore, this study aimed to investigate the effects of ISL exposure on endoplasmic reticulum (ER) stress in zebrafish embryos by examining the expression levels of ER stress markers HSPA5 and CHOP as well as related apoptosis factor under different concentrations of ISL, using Tm as a positive control group. Additionally, we performed targeted analysis of ER stress-related pathways via RNA transcriptome sequencing. The results showed that exposure to ISL induced high expression levels of HSPA5 and CHOP while activating ER stress pPERK-PEIF2a-ATF4 and ATF6 pathways in zebrafish embryos. These findings suggest that activation of endoplasmic reticulum stress signaling pathway may contribute to the developmental deformities observed following exposure to ISL in zebrafish embryos, highlighting potential ecological risks associated with its use.
The burden of skin diseases in China: Global Burden of Disease Study 2019
Authors: Kong Yaoyao , Xing Peiye , Huai Pengcheng , Zhang Furen 
Published: April 2024

Abstract

Skin diseases continue to affect human health and cause a significant disease burden on the healthcare system.We aimed to report the changing trends in the burden of skin disease in China from 1990–2019, Which has an important role in developing targeted prevention strategies. We applied Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2019 analytical tools to calculate the age-standardized Prevalence and Incidence rates in 2019, number of YLDs and agestandardized YLD rate from 1990 to 2019 of skin and subcutaneous diseases, notifiable infectious skin diseases and skin tumors in China. Among the skin and subcutaneous diseases in China in 2019, dermatitis contributed to the greatest years lived with disability (YLD) (2.17 million, 95% uncertainty interval[UI]: 1.28–3.36). Age-standardized YLD rates for leprosy decreased from 0.09 (95%UI: 0.06–0.13) in 1990 to 0.04 (95%UI: 0.03–0.06) in 2019; the proportional decrease was 55.56% over 30 years. Age-standardized YLD rates for HIV and sexually transmitted infections increased by 26% during the same time period. Age-standardized YLD rates for non-melanoma skin cancer increased at a much higher rate than melanoma between 1990 and 2019. Dermatitis and scabies continue to have an important role in the burden of skin and subcutaneous disease burden in China. The burden of non-melanoma cell cancer has increased most significantly over the past three decades.
A case analysis of intracranial infection of Porphyromonas gingivalis
Authors: yuqiwang  
Published: April 2024

Abstract
OBJECTIVE A case of intracranial infection caused by Porphyromonas gingivalis was analyzed to provide evidence for clinical treatment.
METHODS In one patient with intracranial infection, the results of multiple blood culture and cerebrospinal fluid culture were negative, and no pathogenic bacteria were found. Porphyromonas gingivalis in cerebrospinal fluid was determined by macrogene detection method, and the empirical selection of vancomycin combined with ceftriaxone anti-infection treatment was converted to metronidazole target treatment.
RESULTS After 4 weeks of treatment, the patients recovered completely, and the laboratory examination indexes were normal. The results of brain CT and cerebrospinal fluid metagene test were negative.
CONCLUSION For intracranial infection caused by rare microorganisms, under the premise of negative results of classical bacterial culture, advanced macrogene sequencing method can be used to determine pathogens, providing rapid and accurate detection results for clinical treatment.
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Investigating the carcinogenic and non-carcinogenic health hazards of heavy metal ions in Spinacia oleracea grown in agricultural soil treated with biochar and humic acid
Authors: Moradi-Choghamarani Farzad , Ghorbani Farshid 
Published: April 2024

Abstract

This study addressed the bioaccumulation and human health risk among consumption of Spinacia oleracea grown in agricultural soil treated with humic acid and biochars. The biochars came from two local feedstocks of rice husk (RH) and sugar beet pulp (SBP) pyrolyzed at temperatures 300 and 600°C. The effect of soil treatment with biomass/biochar and humic acid in the accumulation of Heavy metals (HMs) in spinach leaves was considered under the controlled laboratory conditions. Optimum conditions for minimum accumulation of HMs were evaluated according to a central composite design (CCD) under the response surface method (RSM) by Design Expert software. Total concentrations of Cu, Cd, and Ni in soil and biomass/biochar were beyond acceptable standards worldwide. The concentrations of Zn, Cd, Pb, and Ni in spinach exceeded the safety threshold limit, and its consumption is not recommended. Results of the desirability test suggested the minimum values of biomass/biochar application rate due to their metal-contaminated nature. The minimum concentration of humic acid also was suggested due to its role in promoting pollutant bioavailability. Results showed that the treatment of metal-contaminated soil with HMs polluted-biochars fails to stabilize pollution. Also, polluted biochars increased the hazard indices for non-carcinogenic and carcinogenic diseases beyond the permissible levels.
Dynamic simulation optimization of hydrogen liquefaction process
Authors: Fu Juntao , Tang Jiahao , Zhu Jianlu , Wang Guocong , Li Yuxing , Han Hui 
Published: April 2024

Abstract
Aiming at the parameter optimization of hydrogen liquefaction process, this paper uses process simulation software Aspen HYSYS to simulate the hydrogen liquefaction process. By establishing the dynamic model of the unit module, this study carried out dynamic simulation optimization based on the steady-state process and process parameters of the hydrogen liquefaction process, and analyzed the dynamic characteristics of the process. Based on the pressure drop characteristic experiment, the pressure drop equation in the heat exchanger is proposed. The heat transfer of hydrogen conversion was simulated and analyzed, and its accuracy was verified by comparing with the literature results. The dynamic simulation of plate-fin heat exchanger was carried out by coupling heat transfer simulation and pressure drop experiment. This study eliminates the influence of the fluctuation of each parameter in the liquefaction process with time, which is of great significance to improve the operation efficiency of the refrigeration cycle and guide the actual production.