bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electronic Word Of Mouth Saat Penjualan Live Streaming Shopee Dalam Meningkatkan Impulse Buying
Authors: Purbasari Dewi Maharani , Respati Mutia Raras 
Published: April 2024

Technological developments have developed so rapidly and have influenced changes in people's lifestyles towards digital. e-commerce is the electronic trading of goods or services via the Internet and social media. The e-commerce that had the most visitors during the first quarter of 157.97 million was Shopee. Shopee not only provides infrastructure for sellers and buyers to transact but also presents various innovative features to improve the online experience. One feature that is increasingly popular on Shopee is live streaming media, where sellers can broadcast live to promote their products to potential buyers.
The purpose of this research is to determine the influence of Electronic Word of Mouth on Impulse Buying, to determine the influence of Live Streaming Sales on Impulse Buying, to determine the influence of Electronic Word of Mouth and Live Streaming Sales together on Impulse Buying. This research uses quantitative methods with a descriptive research approach. With respondents from University Pakuan students. The selection of respondents was carried out using a purposive sampling method with a total of 100 respondents based on the Slovin formula calculation. Data collection was carried out through questionnaires and the analysis method used was descriptive analysis, with multiple linear regression testing with the SPSS program. The research results show that Electronic Word of Mouth has a significant effect on Impulse Buying, live streaming has no significant effect on Impulse Buying, and Electronic Word of Mouth and Live Steaming has a significant effect on impulse buying simultaneously.
Apakah Penggunaan Teknologi Informasi Dan Kepemimpinan Transformasional Dapat Meningkatkan Perrforma Karyawan?
Authors: Sjahruddin Herman , Gumanty Rachmat , Anto Ahmad , Mochtar Hasyim 
Published: April 2024

Employee performance is an achievement achieved by employees when carrying out responsibilities in an agency as an effort to achieve the end of a company that is considered legal in the eyes of the law. The purpose of this finding is to analyze the effect of implementing information technology and transformational leadership on employee performance at PT Bank KB Bukopin Makassar Branch. The number of samples was 159 respondents and 72 data were not used because they did not match the criteria in the study. The results of regression testing show that the use of good information technology will improve employee performance. This condition is different from transformational leadership which shows that transformational leadership does not contribute to employee performance.
Keywords: Banking, information technology, transformational leadership, performance
Pengaruh Brand Image, Harga, Brand Trust Dan Kualitas Produk Terhadap Keputusan Pembelian Lipstik Wardah Di Kota Semarang
Authors: Lestari Meti , Wismantoro Yohan 
Published: April 2024

In general, people really like the cosmetics industry, one of which is lip care which is growing rapidly in Indonesia. The aim of this research is to test the influence of brand image, price, brand trust and quality of Wardah lipstick products on purchasing decisions in the city of Semarang. This study uses a quantitative approach. Sample collection used a purposive sampling method with 175 respondents by distributing questionnaires using Google from. The data analysis process uses SMARTPLS. The results of data processing show that Brand Image and Brand Trust have a significant influence on the decision to purchase Wardah lipstick in the city of Semarang, while price and product quality do not have a significant influence on the decision to purchase Wardah lipstick in the city of Semarang.
Keywords: Brand Image, Price, Brand Trust, Product Quality, Purchasing Decisions.
Revolutionizing Plant Disease Detection: A Review of Deep Learning and Machine Learning Algorithms
Authors: Ekta Kapase  , Prem Bhandari  , Atharva Bodake  , Ujwal Chaudhari  
Published: April 2024

The food industry has led the agricultural economy of the state all India to prosperity. India has historically been the largest producing nation having identity of Agricultural Land. Grains , fruits , Vegetables , such as potatoes, oranges, Tomato ,sugarcane and other specially grains and cottons are the chief crops of the India. Citrus and cotton industries have been a driving force behind Maharashtra's impressive economic growth.. The situation has created job opportunities for many people, boosting the state's economic potential. To maintain the prosperity of citrus and cotton industries, Government has been concerned about disease control, labour cost, and global market.
During the recent past, citrus canker and citrus greening, Black spot-n cotton has become serious threats to citrus in Maharashtra. Infection by these diseases weakens trees, leading to decline, mortality, lower yields, and decreased commercial value. Likewise, the farmers are concerned about costs from tree loss, scouting, and chemicals used in an attempt to control the disease. An automated detection system may help in prevention and, thus reduce the serious loss to the industries, farmers and Economy of country.
This research aims to the development of disease detection with pattern recognition approaches for these diseases in crop. The detection approach consists of three major sub-systems, namely, image acquisition, image processing and pattern recognition. The imaging processing sub-system includes image preprocessing for background noise removal, leaf boundary detection and image feature extraction. Pattern recognition approaches will be use to classify samples among several different conditions on crops.
In order to evaluate the classification approaches, results will be compared between classification methods for the different induvial fruits, vegetable, grains disease detection. Obtained results will help in demonstration of classification accuracy which is targeted as better than existing for proposed model as high as 97.00%. This study aimed to assess the potential of identifying plant diseases by examining visible signs on fruits and leaves. These data collection and initial knowledge acquisition is plan in offline approaches. By implementing this simple model, we can achieve a more favourable cost-to-production ratio compared to complex solutions.
Airway epithelium respiratory illnesses and allergy (AERIAL) birth cohort: study protocol
Authors: Kicic-Starcevich Elizabeth , Hancock David G. , Iosifidis Thomas , Agudelo-Romero Patricia , Caparros-Martin Jose A. , Karpievitch Yuliya V. , Silva Desiree , Turkovic Lidija , Le Souef Peter N. , Bosco Anthony , Martino David J. , Kicic Anthony , Prescott Susan L. , Stick Stephen M. 
Published: April 2024

IntroductionRecurrent wheezing disorders including asthma are complex and heterogeneous diseases that affect up to 30% of all children, contributing to a major burden on children, their families, and global healthcare systems. It is now recognized that a dysfunctional airway epithelium plays a central role in the pathogenesis of recurrent wheeze, although the underlying mechanisms are still not fully understood. This prospective birth cohort aims to bridge this knowledge gap by investigating the influence of intrinsic epithelial dysfunction on the risk for developing respiratory disorders and the modulation of this risk by maternal morbidities, in utero exposures, and respiratory exposures in the first year of life.MethodsThe Airway Epithelium Respiratory Illnesses and Allergy (AERIAL) study is nested within the ORIGINS Project and will monitor 400 infants from birth to 5 years. The primary outcome of the AERIAL study will be the identification of epithelial endotypes and exposure variables that influence the development of recurrent wheezing, asthma, and allergic sensitisation. Nasal respiratory epithelium at birth to 6 weeks, 1, 3, and 5 years will be analysed by bulk RNA-seq and DNA methylation sequencing. Maternal morbidities and in utero exposures will be identified on maternal history and their effects measured through transcriptomic and epigenetic analyses of the amnion and newborn epithelium. Exposures within the first year of life will be identified based on infant medical history as well as on background and symptomatic nasal sampling for viral PCR and microbiome analysis. Daily temperatures and symptoms recorded in a study-specific Smartphone App will be used to identify symptomatic respiratory illnesses.DiscussionThe AERIAL study will provide a comprehensive longitudinal assessment of factors influencing the association between epithelial dysfunction and respiratory morbidity in early life, and hopefully identify novel targets for diagnosis and early intervention.
Prognosis and therapeutic significance of IGF-1R-related signaling pathway gene signature in glioma
Authors: Liu Zhen , Yang Liangwang , Wu Wenqi , Chen Zejun , Xie Zhengxing , Shi Daoming , Cai Ning , Zhuo Shenghua 
Published: April 2024

BackgroundGlioma is the most common cancer of the central nervous system with poor therapeutic response and clinical prognosis. Insulin-like growth factor 1 receptor (IGF-1R) signaling is implicated in tumor development and progression and induces apoptosis of cancer cells following functional inhibition. However, the relationship between the IGF-1R-related signaling pathway genes and glioma prognosis or immunotherapy/chemotherapy is poorly understood.MethodsLASSO–Cox regression was employed to develop a 16-gene risk signature in the TCGA-GBMLGG cohort, and all patients with glioma were divided into low-risk and high-risk subgroups. The relationships between the risk signature and the tumor immune microenvironment (TIME), immunotherapy response, and chemotherapy response were then analyzed. Immunohistochemistry was used to evaluate the HSP90B1 level in clinical glioma tissue.ResultsThe gene risk signature yielded superior predictive efficacy in prognosis (5-year area under the curve: 0.875) and can therefore serve as an independent prognostic indicator in patients with glioma. The high-risk subgroup exhibited abundant immune infltration and elevated immune checkpoint gene expression within the TIME. Subsequent analysis revealed that patients in the high-risk subgroup benefited more from chemotherapy. Immunohistochemical analysis confirmed that HSP90B1 was overexpressed in glioma, with significantly higher levels observed in glioblastoma than in astrocytoma or oligodendrocytoma.ConclusionThe newly identified 16-gene risk signature demonstrates a robust predictive capacity for glioma prognosis and plays a pivotal role in the TIME, thereby offering valuable insights for the exploration of novel biomarkers and targeted therapeutics.
A telehealth application for adequate hospital visit advice by physicians affected users’ subsequent hospital visit behavior: a historical cohort study with machine learning
Authors: Kobashi Yurie , Oguni Masaki , Nakamura Naotoshi , Tsubokura Masaharu , Ito Shunichiro 
Published: April 2024

IntroductionThe effectiveness of telehealth strategies toward support for adequate hospital visits is vital. We examined whether individuals who received advice from a physician via an online application subsequently visited hospitals. Further, we examined the background factors associated with their hospital visit behavior.MethodsWe used machine learning to examine whether chief complaint, medical advice, and user background characteristics could be used to predict their subsequent hospital visit.ResultsAmong 7,152 participants, those in their 30s were the most frequent users. The proportion of each medical advice was significantly different between the group that did and the one that did not follow physicians’ advice. We further performed supervised machine learning using random forest modeling to categorize those who (1) followed physicians’ advice or (2) did not follow physicians’ advice. The area under the receiver operating characteristic curve was 0.677. Consequently, the aforementioned model soundly categorized whether users followed physicians’ advice. Chief complaint and medical advice were the most important variables to predict whether users followed the advice.DiscussionThe telehealth system to provide support for adequate hospital visits influenced patients’ subsequent hospital visit behavior. Patients’ chief complaint was the most important variable in discriminating whether users followed physicians’ advice.
A causal association between amyotrophic lateral sclerosis and atrial fibrillation: a two-sample Mendelian randomization study
Authors: Yao Yiren , Liu Hongyang , Gu Yang , Xu Xiaojin , Zhang Xiwen 
Published: April 2024

ObjectivesTo look into the connection between amyotrophic lateral sclerosis (ALS) and atrial fibrillation (AF) using Mendelian randomization (MR).MethodsTwo-sample MR was performed using genetic information from genome-wide association studies (GWAS). Genetic variants robustly associated with ALS and AF were used as instrumental variables. GWAS genetic data for ALS (n = 138,086, ncase = 27,205) and AF (n = 1,030,836, ncase = 60,620), publicly available from IEU Open. The specific MR protocols were Inverse variance-weighted (IVW), Simple mode, MR Egger, Weighted mode, and Weight median estimator (WME). Subsequently, the MR-Egger intercept and Cochran Q examine were used to evaluate instrumental variables (IVs)' heterogeneity and multiplicative effects (IVs). In addition, MR-PRESSO analysis was conducted to exclude any potential pleiotropy.ResultsThe IVW method demonstrated that ALS positively affected AF [OR: 1.062, 95% CI (1.004–1.122); P = 0.035]. Indeed, other MR methods were in accordance with the tendency of the IVW method (all OR &gt; 1), and sensitivity testing verified the reliability of this MR result.ConclusionsThis MR study proves a positive causal connection between ALS and atrial fibrillation. Further studies are warranted to elucidate the mechanisms linking ALS and AF.
A case report of successful rescue using veno-arterial extracorporeal membrane oxygenation: managing cerebral-cardiac syndrome
Authors: Wang Zheng , Zhang Qi-Feng , Guo Miao , Qi Xiao-Xia , Xing Xiao-Hui , Li Gang , Zhang Shuang-Long 
Published: April 2024

IntroductionThe presence of cerebral-cardiac syndrome, wherein brain diseases coincide with heart dysfunction, significantly impacts patient prognosis. In severe instances, circulatory failure may ensue, posing a life-threatening scenario necessitating immediate life support measures, particularly effective circulatory support methods. The application of extracorporeal membrane oxygenation (ECMO) is extensively employed as a valuable modality for delivering circulatory and respiratory support in the care of individuals experiencing life-threatening circulatory and respiratory failure. This approach facilitates a critical temporal window for subsequent interventions. Consequently, ECMO has emerged as a potentially effective life support modality for patients experiencing severe circulatory failure in the context of cerebral-cardiac syndrome. However, the existing literature on this field of study remains limited.Case descriptionIn this paper, we present a case study of a patient experiencing a critical cerebral-cardiac syndrome. The individual successfully underwent veno-arterial-ECMO (VA-ECMO) therapy, and the patient not only survived, but also received rehabilitation treatment, demonstrating its efficacy as a life support intervention.ConclusionVA-ECMO could potentially serve as an efficacious life support modality for individuals experiencing severe circulatory failure attributable to cerebral-cardiac syndrome.
Vascular complications in craniopharyngioma-resected paediatric patients: a single-center experience
Authors: Castelli Barbara , Scagnet Mirko , Mussa Federico , Genitori Lorenzo , Sardi Iacopo , Stagi Stefano 
Published: April 2024

BackgroundCraniopharyngioma (CP), although slow growing and histologically benign, has high morbidity, mostly related to hypothalamus-pituitary dysfunction and electrolyte imbalance. Increased risk of vascular complications has been described. However, data are still poor, especially in the paediatric population. The aim of our study was to evaluate the occurrence, timing, and predisposing factors of deep venous thrombosis (DVT) and other vascular alterations in neurosurgical paediatric CP patients.Materials and MethodsIn a single-centre, retrospective study, we investigated 19 CP patients (11 males, 8 females, mean age 10.5 ± 4.3 years), who underwent neurosurgery between December 2016 and August 2022, referred to Meyer Children’s Hospital IRCCS in Florence.ResultsFive patients (26.3%) presented vascular events, which all occurred in connection with sodium imbalances. Three DVT (two with associated pulmonary embolism, in one case leading to death) developed in the post-operative period, most frequently at 7-10 days. Elevated D-dimers, a reduced partial activated thrombin time and a prolonged C-reactive protein increase were highly related to thrombotic vascular events. One case of posterior cerebral artery pseudoaneurysm was described soon after neurosurgery, requiring vascular stenting. Superficial vein thrombophlebitis was a late complication in one patient with other predisposing factors.ConclusionCP patients undergoing neurosurgery are at risk of developing DVT and vascular alterations, thus careful follow-up is mandatory. In our study, we found that the phase of transition from central diabetes insipidus to a syndrome of inappropriate antidiuretic hormone secretion may be a period of significant risk for DVT occurrence. Careful vascular follow-up is mandatory in CP-operated patients.
The maintenance of long-term weight loss after semaglutide withdrawal in obese women with PCOS treated with metformin: a 2-year observational study
Authors: Jensterle Mojca , Ferjan Simona , Janez Andrej 
Published: April 2024

BackgroundWithdrawal of semaglutide is frequently followed by weight regain due to compensatory biological changes that prevent the maintenance of long-term weight loss. There are some studies implying that metformin might attenuate weight regain. The weight trajectory after discontinuation of short-term semaglutide treatment in obese women with PCOS who continued metformin treatment has not yet been evaluated.AimsWe explored changes in body weight, cardiometabolic and endocrine parameters in obese women with PCOS who continued treatment with metformin 2 years after discontinuation of short-term intervention with semaglutide.Methods25 women with PCOS and obesity, aged 33.7 ± 5.3 years (mean ± SD), were treated with once-weekly subcutaneous semaglutide 1.0 mg as an adjunct to metformin 2000 mg/day and lifestyle intervention for 16 weeks. At week 16, semaglutide was discontinued. Treatment with metformin 2000 mg/day and promotion of lifestyle intervention were continued during the 2-year follow-up period. Weight change, cardiometabolic, and endocrine parameters were assessed 2 years after semaglutide discontinuation.ResultsDuring semaglutide treatment phase, weight decreased from 101 (90-106.8) kg to 92 (83.3-100.8) kg. Two years after semaglutide withdrawal, weight was 95 (77-104) kg. The net weight loss 2 years after discontinuation of semaglutide remained significant when compared to baseline (p=0.003). At the end of the study, 21 out of 25 subjects had lower body weight compared to baseline. Improvements in cardiometabolic parameters including decrease in total and LDL cholesterol, fasting glucose, and glucose after OGTT that had been seen during semaglutide-treatment phase reverted towards baseline two years after semaglutide cessation. Free testosterone levels significantly decreased during semaglutide treatment from 6.16 (4.07-9.71) to 4.12 (2.98-6.93) nmol/l, (p= 0.012) and did not significantly deteriorate after semaglutide discontinuation.ConclusionTwo years after semaglutide withdrawal, women with PCOS who continued with metformin regained about one-third of the semaglutide-induced weight loss. At the end of the follow up, 84% of women had a lower body weight than at baseline.
Concomitant use of interleukin-2 and tacrolimus suppresses follicular helper T cell proportion and exerts therapeutic effect against lupus nephritis in systemic lupus erythematosus-like chronic graft versus host disease
Authors: Nasa Yutaro , Satake Atsushi , Tsuji Ryohei , Saito Ryo , Tsubokura Yukie , Yoshimura Hideaki , Ito Tomoki 
Published: April 2024

IntroductionDefective interleukin-2 (IL-2) production contributes to immune system imbalance in patients with systemic erythematosus lupus (SLE). Recent clinical studies suggested that low-dose IL-2 treatment is beneficial for SLE and the therapeutic effect is associated with regulatory T cell (Treg) expansion. Pharmacological calcineurin inhibition induces a reduction in the number of Tregs because they require stimulation of T cell receptor signaling and IL-2 for optimal proliferation. However, the activation of T cell receptor signaling is partially dispensable for the expansion of Tregs, but not for that of conventional T cells if IL-2 is present.AimWe examined whether addition of IL-2 restores the Treg proportion even with concurrent use of a calcineurin inhibitor and if the follicular helper T cell (Tfh) proportion is reduced in an SLE-like murine chronic graft versus host disease model.MethodsUsing a parent-into-F1 model, we investigated the effect of IL-2 plus tacrolimus on Treg and Tfh proportions and the therapeutic effect.ResultsTreatment with a combination of IL-2 and tacrolimus significantly delayed the initiation of proteinuria and decreased the urinary protein concentration, whereas tacrolimus or IL-2 monotherapy did not significantly attenuate proteinuria. Phosphorylation of signal transducer and activator of transcription 3, a positive regulator of Tfh differentiation, was reduced by combination treatment, whereas phosphorylation of signal transducer and activator of transcription 5, a negative regulator, was not reduced.ConclusionAddition of calcineurin inhibitors as adjunct agents may be beneficial for IL-2-based treatment of lupus nephritis.
Case report: Atypical case of autoimmune glial fibrillary acidic protein astrocytopathy following COVID-19 vaccination refractory to immunosuppressive treatments
Authors: Morishima Yuto , Hata Takanori , Nakajima Sho , Shindo Kazumasa , Tsuchiya Mai , Watanabe Tsubasa , Tahara Ippei , Kondo Tetsuo , Kimura Akio , Shimohata Takayoshi , Ueno Yuji 
Published: April 2024

A 54-year-old Japanese man presented with headache and fever the day after SARS-CoV-2 vaccination. He became deeply unconscious within a week. Brain MRI showed periventricular linear enhancements and a few spotty lesions in the cerebral white matter. Cerebrospinal fluid (CSF) testing showed mild pleocytosis. He was treated with intravenous methylprednisolone and plasma exchange. However, the white matter lesions enlarged to involve the brainstem and cerebellum, and long cord spinal lesions appeared. Anti-glial fibrillary acidic protein (GFAP) antibody was positive in the CSF and serum, and he was therefore diagnosed as autoimmune GFAP-astrocytopathy (GFAP-A). In addition, high-dose immunoglobulin therapy was administered twice, but his symptoms did not improve; the white matter lesions enlarged further, and modified Rankin Scale score increased to 5. A brain biopsy specimen showed infiltration of macrophages and CD4+ lymphocytes together with neuron and oligodendrocytic injuries and glial scar. Although GFAP-A generally responds well to steroids, the present case developed GFAP-A following SARS-CoV-2 vaccination, with refractory to intensive immunosuppressive therapy and atypical pathologic findings of infiltration of CD4+ lymphocytes and demyelination.