bluuebunny/crossref_metadata_2025_split huggingface dataset:
Service selection and workflow mapping for Grids: an approach exploiting quality‐of‐service information
Authors: Kyriazis Dimosthenis , Tserpes Konstantinos , Menychtas Andreas , Sarantidis Ioannis , Varvarigou Theodora 
Published: July 2008

AbstractThe advent of heterogeneous and distributed environments, such as Grid environments, made feasible the solution to computational‐intensive problems in a reliable and cost‐effective manner. In parallel, workflows with increased complexity that require specialized systems to deal with them are emerging, so as to carry out more composite and mission‐critical applications. In that rationale, quality‐of‐service (QoS) issues need to be tackled in order to ensure that each application satisfies the corresponding user requirements. Therefore, considering the quality provision aspect as fundamental for enabling Grid applications to become QoS compliant, we present an approach for service selection using QoS criteria. The latter is achieved with a suite of components that allow the different mappings of application workflow processes to Grid services that not only meet the user goals and requirements but also maximize his/her benefit in terms of the offered QoS level. We also demonstrate the operation of the aforementioned suite of components and evaluate its performance and effectiveness using a Grid scenario, based on a 3D image rendering application. Copyright © 2008 John Wiley & Sons, Ltd.
Faster, cheaper, and unused: The paradox of grievance mediation in unionized environments
Authors: Monahan Camille 
Published: July 2008

AbstractThis article investigates the paradox that grievance mediation pilot programs, despite their overwhelming successes, have failed to be adopted on a widespread basis in unionized settings. By focusing largely on the labor union perspective, this article suggests that some elements of union organizational identity act as barriers to the mediation of contract‐based labor disputes. Also, a model and a case study are presented to shed light on the factors that create contract‐based, unmediated grievances.
A narrative approach to bioethical decision making: The missing link between bioethics and conflict management?
Authors: Barton Ansley 
Published: July 2008

AbstractBeginning in the 1990s and continuing today with increasing velocity, advances in science and medicine have profoundly affected not only health and health care, but also ethical thinking as well. Physicians, researchers, patients, and families are increasingly called on to make difficult decisions between competing values, which provides fodder for serious conflict. This article discusses a narrative approach to bioethical decision making and suggests that lessons from the field of conflict management could enhance its promise.
Assessment of pediatric dysphagia and feeding disorders: Clinical and instrumental approaches
Authors: Arvedson Joan C. 
Published: July 2008

AbstractAssessment of infants and children with dysphagia (swallowing problems) and feeding disorders involves significantly more considerations than a clinical observation of a feeding. In addition to the status of feeding in the child, considerations include health status, broad environment, parent–child interactions, and parental concerns. Interdisciplinary team approaches allow for coordinated global assessment and management decisions. Underlying etiologies or diagnoses must be delineated to every extent possible because treatment will vary according to history and current status in light of all factors that are often interrelated in complex ways. A holistic approach to evaluation is stressed with a primary goal for every child to receive adequate nutrition and hydration without health complications and with no stress to child or to caregiver. Instrumental swallow examinations that aid in defining physiological swallowing status are needed for some children. Successful oral feeding must be measured in quality of meal time experiences with best possible oral sensorimotor skills and safe swallowing while not jeopardizing a child's functional health status or the parent–child relationship. © 2008 Wiley‐Liss, Inc. Dev Disabil Res Rev 2008;14:118–127.
Neuropharmacology of human appetite expression
Authors: Halford Jason C.G. , Harrold Joanne A. 
Published: July 2008

AbstractThe regulation of appetite relies on the integration of numerous episodic (meal) and tonic (energy storage) generated signals in energy regulatory centres within the central nervous system (CNS). These centers provide the pharmacological potential to modify human appetite (hunger and satiety) to increase or decrease caloric intake, or to normalize aberrant eating behavior. With regard to obesity, the satiety enhancing anti‐obesity drug sibutramine has proved effective at reducing body weight. Additionally, the endocannabinoid CB1 antagonist rimonabant has recently been approved for use in Europe (but not in the US). A 5‐HT2C agonist lorcaserin is also currently undergoing large‐scale clinical trials, but the effect of the drug on human appetite is unknown as yet. Appetite enhancing drugs such as magestrol acetate and dronabiol are currently used to promote weight gain. Finally, sibutramine, selective serotonergic reuptake inhibitors such as fluoxetine and some anti‐epileptic drugs have all been used to normalise aberrant eating behaviour. All these drugs act by modifying the expression of human appetite. An assessment of a drug's effectson caloric intake and feelings of hunger and satiety is necessary before they can be considered for clinical use. © 2008 Wiley‐Liss, Inc. Dev Disabil Res Rev 2008;14:158–164.
Grasping force control in consideration of translational and rotational slippage of an object by a flexible contact sensor
Authors: Saito Naoki , Satoh Toshiyuki , Okano Hideharu 
Published: July 2008

AbstractThis paper addresses the issue of translational and rotational slippage that occurs when a robot hand grasps an object. To grasp an object against each directional slippage is an important task. In this study, to deal with rotational slippage, a contact area between a flexible contact sensor which is mounted on the robot hand and the object is considered. A sufficient condition for grasping an object against translational/rotational slippage is derived on the condition that no additional sensors, such as tactile sensors, are required.Effectiveness of the condition is confirmed by a grasping experiment with the use of a translational gripper where the flexible contact sensor is mounted. © 2008 Wiley Periodicals, Inc. Electr Eng Jpn, 165(3): 51–57, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20579
A magnetic yoke probe for in situ magnetic measurements
Authors: Kikuchi Hiroaki , Liu Tong , Ara Katsuyuki , Kamada Yasuhiro , Kobayashi Satoru , Takahashi Seiki 
Published: July 2008

AbstractA probe with a magnetic yoke for nondestructive evaluation of mechanical properties was developed. This probe can evaluate the magnetic properties of ferromagnetic materials without machining them to a ring core or frame core shape, that is, it can perform in situ measurements. In this paper, the magnetic properties measured by the magnetic yoke probe are compared with the mechanical properties and a good correlation is found, suggesting a potential use of the probe for nondestructive evaluation of mechanical properties in ferromagnetic materials. The effect of an air gap between the probe and the specimen was also investigated in order to address possible contact problems in industrial applications. © 2008 Wiley Periodicals, Inc. Electr Eng Jpn, 165(3): 1– 7, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20588
Performance analysis of PSO‐based parallel interference canceller for MC‐CDMA communication systems
Authors: Lee Shu‐Hong , Hung Ho‐Lung , Huang Yung‐Fa , Wen Jyh‐Horng 
Published: July 2008

AbstractThis work analyses the performance of particle swarm optimisation (PSO) algorithm‐based parallel interference cancellation (PIC) multiuser detectors exploited in multicarrier direct‐sequence code‐division multiple‐access (MC‐DS‐CDMA) communication systems over frequency‐selective fading channels. The PSO, which attempts to reduce the complexity in optimal detection caused by the greedy exhausted searching, achieves adequate sub‐optimal multiuser detection in CDMA systems. Simulation results reveal that with a lower generation ofGn = 5, 10, the constant weight PIC (CWPIC) scheme outperform the conventional PIC (CPIC) particularly at heavy load. However, with higher generationGn = 20 in PSO, the CPIC schemes contrarily outperform the CWPIC for all system loads. Copyright © 2008 John Wiley & Sons, Ltd.
Minocycline reduces engraftment and activation of bone marrow‐derived cells but sustains their phagocytic activity in a mouse model of Alzheimer's disease
Authors: Malm Tarja M. , Magga Johanna , Kuh Georges Ful , Vatanen Tero , Koistinaho Milla , Koistinaho Jari 
Published: July 2008

AbstractBone marrow (BM)‐derived monocytes contribute to the development of microglial reaction around β‐amyloid (Aβ) plaques in Alzheimer's disease (AD) and possibly clear Aβ. Therefore, it is of great importance to separate the proinflammatory actions of monocytic cells from Aβ phagocytic effects. We used minocycline (mino) to systemically downregulate microglial activation and studied proliferation, expression of markers for activated microglia, and Aβ removal in vitro and in vivo. Mino did not affect proliferation or phagocytic activity of BM‐derived cells toward Aβ in vitro. Intrahippocampal LPS injection used to induce inflammation and increase recruitment of BM cells from periphery, reduced Aβ burden in BM‐transplanted AD transgenic mice. All engrafted cells expressed CD45, ∼50% expressed Iba‐1, and <0.5% of these cells expressed CD3e. About 40% of the engrafted cells were mitotically active. LPS increased immunoreactivity for Iba‐1, MHC II, a marker of antigen presenting cells, and CD68, a marker of lysosomal activity. The endogenous microglia largely contributed to these LPS‐induced immunoreactivities. Mino reduced the engraftment of BM‐derived cells and blocked the LPS‐induced MHC II and Iba‐1 immunoreactivities, but did not prevent the increased CD68‐immunoreactivity or the reduced Aβ burden. Importantly, mino did not block the association of eGFP‐positive cells with Aβ deposits and the percentage of mitotically active BM‐derived cells. In conclusion, mino reduces overall inflammatory potential of BM‐derived monocytic cells without preventing their phagocytic activity. The separation of harmful activation of microglia/monocytic cells from their Aβ clearing mechanism may hold important therapeutic potential. © 2008 Wiley‐Liss, Inc.
Vitamin E increases S100B‐mediated microglial activation in an S100B‐overexpressing mouse model of pathological aging
Authors: Bialowas‐McGoey Lynn A. , Lesicka Agnieszka , Whitaker‐Azmitia Patricia M. 
Published: July 2008

AbstractS100B is a calcium‐binding protein released by astroglial cells of the brain capable of producing numerous extracellular effects. Although the direct molecular mechanism remains unknown, these effects can be trophic including differentiation, growth, recovery, and survival of neurons when the S100B protein is mainly oxidized and neurotoxic including apoptosis and neuroinflammatory processes marked by microglial activation when in a reduced state. S100B and its receptor RAGE (receptor for advanced glycation end products) have been found to be increased in Alzheimer's disease, Down syndrome, with tissue trauma and ischemia. In the current study, we examined the binding of the S100B receptor (RAGE) on microglial cells and the developmental effects of the antioxidant vitamin E on microglial activation and the upregulation of RAGE in an S100B over‐expressing mouse model of pathological aging. We report that RAGE is co‐localized on activated microglial cells and vitamin E induced dramatic increases in microglial activation as well as total microglial relative optical density that was accompanied by upregulation of the RAGE receptor, particularly in the CA1 region of the hippocampus. Our findings suggest further investigation into the potential role of vitamin E in reducing the oxidation state of the S100B protein and its influence on neuroinflammatory processes marked by microglial activation in vivo. © 2008 Wiley‐Liss, Inc.
Adhesive properties of connexin hemichannels
Authors: Cotrina M. L. , Lin J. H.‐C. , Nedergaard M. 
Published: July 2008

AbstractGap junctions are intercellular channels formed by hemichannels (or connexons) from two neighboring cells. Hemichannels, which are composed of proteins called connexins, can function as conduits of ATP and glutamate, and interact with adhesion molecules and other signaling elements. As a result, their functional repertoire is expanding into other roles, such as control of cell growth or cell migration. Here we further elucidate the involvement of hemichannels in cell–cell adhesion by analyzing how connexins regulate cell adhesion without the need of gap junction formation. Using a short‐term aggregation assay with C6‐glioma and HeLa cells stably transfected with connexin (Cx) 43 or Cx32, we found that the connexin type dictates the ability of these cells to aggregate, even though these two cell types do not usually adhere to each other. We have also found that high expression of Cx43, but not Cx32 hemichannels, can drive adhesion of cells expressing low levels of Cx43. Aggregation was not dependent on high levels of extracellular Ca2+, as Ca2+ removal did not change the aggregation of Cx43‐expressing cells. Our data confirm that connexin hemichannels can establish adhesive interactions without the need for functional gap junctions, and support the concept that connexins act as adhesion molecules independently of channel formation. © 2008 Wiley‐Liss, Inc.
Clusterin is epigenetically regulated in prostate cancer
Authors: Rauhala Hanna E. , Porkka Kati P. , Saramäki Outi R. , Tammela Teuvo L.J. , Visakorpi Tapio 
Published: July 2008

AbstractLack of good models has complicated investigations on the mechanisms of prostate cancer. By far, the most commonly used transgenic mouse model of prostate cancer is TRAMP, which, however, has not been fully characterized for genetic and epigenetic aberrations. Here, we screened TRAMP‐derived C2 cell line for the alterations using different microarray approaches, and compared it to human prostate cancer. TRAMP‐C2 had relatively few genomic copy number alterations according to array comparative genomic hybridization (aCGH). However, the gene copy number and expression were significantly correlated (p < 0.001). Screening genes for promoter hypermethylation using demethylation treatment with 5‐aza‐2′‐deoxycytidine and subsequent expression profiling indicated 43 putatively epigenetically silenced genes. Further studies revealed that clusterin is methylated in the TRAMP‐C2 cell line, as well as in the human prostate cancer cell line LNCaP. Its expression was found to be significantly reduced (p < 0.01) in untreated and hormone‐refractory human prostate carcinomas. Together with known function of clusterin, the data suggest an epigenetic component in the regulation of clusterin in prostate cancer. © 2008 Wiley‐Liss, Inc.
Toward an early diagnosis of lung cancer: An autoantibody signature for squamous cell lung carcinoma
Authors: Leidinger Petra , Keller Andreas , Ludwig Nicole , Rheinheimer Stefanie , Hamacher Jürg , Huwer Hanno , Stehle Ingo , Lenhof Hans‐Peter , Meese Eckart 
Published: July 2008

AbstractSerum‐based diagnosis offers the prospect of early lung carcinoma detection and of differentiation between benign and malignant nodules identified by CT. One major challenge toward a future blood‐based diagnostic consists in showing that seroreactivity patterns allow for discriminating lung cancer patients not only from normal controls but also from patients with non‐tumor lung pathologies. We addressed this question for squamous cell lung cancer, one of the most common lung tumor types. Using a panel of 82 phage‐peptide clones, which express potential autoantigens, we performed serological spot assay. We screened 108 sera, including 39 sera from squamous cell lung cancer patients, 29 sera from patients with other non‐tumor lung pathologies, and 40 sera from volunteers without known disease. To classify the serum groups, we employed the standard Naïve Bayesian method combined with a subset selection approach. We were able to separate squamous cell lung carcinoma and normal sera with an accuracy of 93%. Low‐grade squamous cell lung carcinoma were separated from normal sera with an accuracy of 92.9%. We were able to distinguish squamous cell lung carcinoma from non‐tumor lung pathologies with an accuracy of 83%. Three phage‐peptide clones with sequence homology to ROCK1, PRKCB1 and KIAA0376 reacted with more than 15% of the cancer sera, but neither with normal nor with non‐tumor lung pathology sera. Our study demonstrates that seroreactivity profiles combined with statistical classification methods have great potential for discriminating patients with squamous cell lung carcinoma not only from normal controls but also from patients with non‐tumor lung pathologies. © 2008 Wiley‐Liss, Inc.
Replication of a genome‐wide case–control study of esophageal squamous cell carcinoma
Authors: Ng David , Hu Nan , Hu Ying , Wang Chaoyu , Giffen Carol , Tang Ze‐Zhong , Han Xiao‐You , Yang Howard H. , Lee Maxwell P. , Goldstein Alisa M. , Taylor Philip R. 
Published: July 2008

AbstractIn a previous pilot case–control study of individuals diagnosed with esophageal squamous cell carcinoma (ESCC) and matched controls from a high‐risk area in China, we identified 38 single nucleotide polymorphisms (SNPs) associated with ESCC located in or near one of 33 genes. In our study, we attempted to replicate the results of these 38 gene‐related SNPs in a new sample of 300 ESCC cases and 300 matched controls from the same study conducted in Shanxi Province, China. Among 36 evaluable SNPs, 4 were significant in one or more analyses, including SNPs located in EPHB1, PGLYRP2, PIK3C3 and SLC9A9, although the odds ratios (ORs) for these genotypes were modest. Associations were found with EPHB1/rs1515366 (OR 0.92, 95% CI 0.86–0.99; p = 0.019), PIK3C3/rs52911 (OR 0.93, 95% CI 0.88–0.99; p = 0.02) and PGLYRP2/rs959117 (OR 0.93, 95% CI, 0.86–1.01; p = 0.061) in general linear models (additive mode); and the genotype distribution differed between cases and controls for SLC9A9/rs956062 (p = 0.024). To examine these 4 genes in more detail, 40 HapMap‐based tag SNPs from these 4 genes were evaluated in the same subjects and 7 additional SNPs associated with ESCC were identified. Further confirmation of these findings in other populations and other studies are needed to determine if the signals from these SNPs are indirectly associated due to linkage disequilibrium, or are directly related to biologic function and the development of ESCC. Published 2008 Wiley‐Liss, Inc.
The human Y‐encoded testis‐specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein
Authors: Kido Tatsuo , Lau Yun‐Fai Chris 
Published: July 2008

AbstractTestis‐specific protein Y‐encoded (TSPY) is the putative gene for the gonadoblastoma locus on the Y chromosome. TSPY is expressed in normal germ cells of fetal and adult testis and ectopically in tumor germ cells, including gonadoblastoma in intersex patients, testicular germ cell tumors, prostate cancer and other somatic cancers. It is a member of the TSPY/SET/NAP1 superfamily and harbors a highly conserved domain, termed SET/NAP domain. To explore its possible role(s) in tumorigenesis, we had performed a yeast two‐hybrid screen of a fetal gonadal cDNA library and identified the translation elongation factor eEF1A as a binding partner for TSPY at the SET/NAP domain. TSPY and eEF1A were highly expressed and colocalized in tumor germ cells of human seminoma specimens, suggesting their possible interaction in germ cell tumors. They were colocalized in the cytoplasm and could be co‐immunoprecipitated from transfected COS7 cells. Significantly, both eEF1A1 and eEF1A2 have postulated to be involved in various types of human cancer, including breast and prostate cancers. TSPY enhanced protein synthesis of a reporter gene, which was augmented by an overexpression of eEF1A. TSPY also increased the nuclear redistribution of eEF1A, resulting in a parallel increase in reporter gene transcripts. Our results suggest that TSPY could exert its oncogenic function(s) by interacting with eEF1As and stimulating gene expression via its enhancements in protein synthesis and gene transcription. Published 2008 Wiley‐Liss, Inc.
Application of local and global particle swarm optimization algorithms to optimal design and operation of irrigation pumping systems
Authors: Afshar M. H. , Rajabpour R. 
Published: July 2008

AbstractA particle swarm optimization (PSO) algorithm is used in this paper for optimal design and operation of irrigation pumping systems. An irrigation pumping systems design and management model is first introduced and subsequently solved with the newly introduced PSO algorithm. The solution of the model is carried out in two steps. In the first step an exhaustive enumeration is carried out to find all feasible sets of pump combinations able to cope with a given demand curve over the required period. The PSO algorithm is then called in to search for optimal operation of each set. Having solved the operation problem of all feasible sets, the total cost of operation and depreciation of initial investment is calculated for all the sets and the optimal set and the corresponding optimal operating policy is determined. The proposed model is applied to the design and operation of a real‐world irrigation pumping system and the results are presented and compared with those of a genetic algorithm. Two global and local versions of the PSO algorithm are used and their efficiencies are compared to each other and that of a genetic algorithm (GA) model. The results indicate that the proposed model in conjunction with the PSO algorithm is a versatile management model for the design and operation of real‐world irrigation pumping systems. Copyright © 2008 John Wiley & Sons, Ltd.
Performance assessment of irrigation management transfer from government‐managed to farmer‐managed irrigation system: a case study
Authors: Latif Muhammad , Tariq Javaid A. 
Published: July 2008

AbstractThe government of NWFP, Pakistan, established an autonomous body, the Frontier Irrigation and Drainage Authority (FIDA), in 1997 to effectively cope with the emerging challenges in irrigation management. Six distributaries were recently transferred to farmers' organizations under the irrigation management transfer (IMT) for their operation and management. Results of the study revealed that the irrigation supplies are adequate to meet the crop water requirements. The relative water supply (RWS) index varies from 1.66 to 2.02 during summer, whereas in winter it varies from 2.22 to 2.55. The delivery performance ratio (DPR) during summer varies from 0.78 to 0.83 and in winter from 0.73 to 0.63. Irrigation supplies were reliable during both summer and winter seasons. Due to improved irrigation supply, annual irrigation intensity has increased by 25%. There is a prominent increase in yield of maize (40%), sugarcane (55%) and wheat (43%). The irrigation service fee collected was approximately 60% of the fee assessed. Hydraulic committees at each distributary should be established to operate the distributary according to crop demand. Awareness of the farmers should be created regarding the farm irrigation application methods to avoid over‐irrigation and wastage of water. Copyright © 2008 John Wiley & Sons, Ltd.