bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary site management following induction chemotherapy with cis‐platinum, 5‐fluorouracil, and leucovorin
Authors: Busse Paul M. , Clark John R. , Beard Clair J. , Dreyfuss Arnon I. , Lucarini James W. , Rossi Renee , Casey Donna , Norris Charles M. 
Published: February 2007

AbstractA phase II clinical trial was initiated in 1987 to evaluate a new induction regimen of cis‐platinum, 5‐fluorouracil, and leucovorin (PFL) for patients with stages III–IV squamous cell carcinoma of the head and neck. Ninety patients were treated and followed for a median duration of 18 months. The median age was 55 and 87% of the patients had stage IV disease. The rates of complete and overall clinical response following three cycles of PFL were 57% and 80%, respectively; the rate of complete response at the primary site was 72%. Eighty‐four percent of patients were treated to the primary site with radiation alone (median dose 68 Gy in daily 1.8‐Gy fractions) irrespective of the location of the primary site or initial T‐stage. The acute tolerance to full‐course radiation following PFL was acceptable. The actuarial rate of primary site control for patients treated, with radiation was 67% at 36 months. An important prognostic indicator for primary site control was a complete clinical response to induction PFL. For patients who achieved a complete response, radiation or surgery followed by radiation controlled primary site disease equally well at 70%. Patients with a partial response did less well. For these patients, surgery and radiation appeared slightly better than radiation alone.
Cervical manifestations of fibrosing mediastinitis: A diagnostic and therapeutic dilemma
Authors: Meredith Scott D. , Madison Jennifer , Fechner Robert E. , Levine Paul A. 
Published: February 2007

AbstractFibroinflammatory and fibrosclerosing lesions involving the head and neck outside the thyroid and orbit are exceedingly rare. We present two cases of fibroinflammatory and fibrosclerosing lesions originating in the mediastinum which extended superiorly to involve soft tissues of the neck. These cases indicate that a subset of fibroinflammatory and fibrosclerosing lesions found in the head and neck originate in the mediastinum.
Tumors of the skull base: Outcome and survival analysis of 77 cases
Authors: Irish Jonathan C. , Gullane Patrick J. , Gentili Fred , Freeman Jeremy , Boyd J. Brian , Brown Dale , Rutka John 
Published: February 2007

AbstractWe reviewed our experience with combined approaches to lesions that transcend the bones of the skull base. Seventy‐seven skull base procedures were performed on 73 patients during a 10‐year period from 1982 to 1992. There were 34 patients (44%) with region I lesions (anterior), seven patients (9%) with region II lesions (anterior‐lateral), 25 patients (32%) with region III lesions (lateral‐posterior), and 11 patients (14%) with lesions that invaded more than one anatomic site. The histopathology in this series was quite variable, with 22 patients (29%) having squamous cell carcinoma and eight patients (10%) having basal cell carcinoma. Forty‐one patients had surgery by an anterior approach and 38 patients had lateral approaches, with 18 undergoing an infratemporal approach and 29 undergoing temporal bone resections. Overall, 44% of the patients had a postoperative complication. Survival of this heterogeneous group of patients is 79% at 2 years and 71% at 4 years, with those patients with region II disease having a statistically significant poorer prognosis with no survivors at 4 years. © 1994 John Wiley & Sons, Inc.
Congenital extraskeletal Ewing's sarcoma of the face: A case report
Authors: Lim Thiam Chye , Tan Walter Tiang Lee , Lee Yoke Sun 
Published: February 2007

AbstractThis is the first reported case of congenital extraskeletal Ewing's sarcoma (EES) in the head and neck region. The tumor arose from the medial aspect of the right lower eyelid and rapidly increased in size despite surgery and chemotherapy. Accurate histologic diagnosis is emphasized, and the differential diagnosis, pathology, and treatment are discussed. © 1994 John Wiley & Sons, Inc.
Benign tracheogastric fistula: A late complication of pharyngogastric anastomosis
Authors: Zitsch Robert P. , Vallery Samuel W. , Deese Lawrence 
Published: February 2007

AbstractThis report describes a benign tracheogastric fistula that developed 2 years after pharyngoesophagectomy, right radical neck dissection, and pharyngogastric anastomosis for recurrent peristomal squamous cell carcinoma. The fistula most likely developed as the result of inflammatory disease of the trachea, stomach, or both. We discuss the common complications of pharyngogastric anastomosis and its management, as well as the management of the tracheogastric fistula. © 1994 John Wiley & Sons, Inc.
Risk factors for complications in clean‐contaminated head and neck surgical procedures
Authors: Girod Douglas A. , McCulloch Timothy M. , Tsue Terance T. , Weymuller Ernest A. 
Published: February 2007

AbstractBackground. Contamination of a head and neck surgical wound with oropharyngeal secretions has been shown to dramatically increase the incidence of wound complications. Appropriate perioperative antibiotic prophylaxis has significantly reduced contaminated wound infection rates in several previous reports. The current study examined multiple patient parameters to determine risk factors for all perioperative complications following clean‐contaminated head and neck surgical procedures.Methods. Retrospective review of medical records from 159 patients who underwent clean‐contaminated major head and neck surgical procedures at the University of Washington between 1985 and 1991. More than 30 preoperative and operative parameters were evaluated, and all complications were recorded. The data were examined using a multivariate statistical analysis.Results. An overall complication rate of 63% included 22% with wound infections (oro/pharyngocutaneous fistula or purulent drainage), 22% with other types of infections, and 51% with noninfectious complications. The overall perioperative mortality rate was 1.2% (two patients). Prior radiotherapy, operative time, perioperative transfusion, and flap reconstruction were all associated with a significantly higher overall complication rate (p ≤ 0.05). Only prior radiotherapy therapy correlated with an increase in wound infection rate (p = 0.05).Conclusions. Prior radiotherapy significantly increases the risk of perioperative complications and wound infections following clean‐contaminated head and neck surgical procedures. Other factors reflecting the complexity of the procedure also influence the overall complication rate. © 1995 Jons Wiley & Sons, Inc.
Surgical access to tumors of the cervicothoracic junction
Authors: Kraus Dennis H. , Huo Jerry , Burt Michael 
Published: February 2007

AbstractBackground. Surgical resection of tumors of the cervicothoracic junction is often problematic due to the limitations imposed by the thoracic cage and adjacent neurovascular structures. The majority of surgical approaches to this region have been designed with the intent of providing adequate exposure for vertebrectomy with tumor resection and vertebral column stabilization. Theses approaches do not provide adequate exposure for a heterogeneous group of tumors which also involve the cervicothoracic junction. We used a combined cervicothoracic surgical approach to determine its efficacy in tumor resection.Method. Seventeen patients with a heterogeneous group of malignancies arising in a variety of soft tissues underwent combined cervicothoracic resection. The approach consisted of anterior cervical access, median sternotomy, and anterior thoracotomy.Results. Complete gross tumor resection was accomplished in all 17 patients, 15 of whom had negative microscopic margins. Extensive reconstruction was employed in 6 patients. Three patients received intraoperative brachytherapy implants and 5 patients received external‐beam postoperative radiotherapy. Local tumor control was obtained in 12 patients, and 10 patients are currently alive, free of disease (median: 12 months; range: 3–47 months). There was no inadvertent sacrifice of neurovascular structures. The sternoclavicular joint was maintained in all patients. There were 4 major complications, and no perioperative mortality associated with the surgical procedure.Conclusion. The combined “trap door” technique provides sufficient exposure for resection of cervicothoracic tumors. Surgery is performed with limited morbidity with the sparing of uninvolved neurovascular structures. The sternoclavicular joint was maintained in all patients. Preliminary results using this approach for resections of tumors of the cervicothoracic junction are encouraging. © 1995 Jons Wiley & Sons, Inc.
Cell adhesion and regulatory molecules involved in tumor formation, hemostasis, and wound healing
Authors: van Waes Carter 
Published: February 2007

AbstractBackground. Dynamic changes in cell adhesion and migration are fundamental properties of the cells that are important in hemostasis, vascularization, and wound repair. Changes in cell adhesion and migration are very important in the formation of tumors, and invasion and metastasis by neoplasms.Methods. Using immunolocalization and immunopurification techniques, expression of integrin molecules involved in cell adhesion has been characterized during tumor development and wound healing. The ability of cytokines to regulate expression and antibody and peptide inhibitors to inhibit function of integrins has been explored to better understand the role of integrins in pathogenesis.Results. Increased suprabasilar expression of the integrins α6β4, α2β1, and α3β1 accompanies development of squamous cell neoplasms of the head and neck. Integrin αllβ3 is an integrin receptor which is important in platelet aggregation in hemostasis and formation of tumor metastases. Increased expression of integrin αvβ3 has been identified in angiogenesis in response to growth factors and tumor angiogenic factors. Cytokine TGF‐β and arachadonic acid metabolite 12(S)‐HETE are important signals in regulation of integrins and affect cell aggregation and migration in these processes. Ligands and inhibitors for some of these receptors have been identified which will be useful in determining their role during tumor development and progression.Conclusions. Recent advances in understanding the functions of the integrin cell adhesion molecules may soon add new diagnostic methods and therapies to the armamentarium of the head and neck oncologic, microvascular, plastic, and reconstructive surgeon. Therapies directed at controlling integrin cell‐adhesion molecule expression and function are being explored to improve scar formation, bone synthesis, inhibition of vascular occlusion, and inhibition of tumor invasion and metastasis. © 1995 Jons Wiley & Sons, Inc.
Definitive radiotherapy for T1 and T2 squamous cell carcinoma of the tonsil
Authors: Moose B. Dawn , Kelly Maria D. , Levine Paul A. , Constable William C. , Cantrell Robert W. , Larner James M. 
Published: February 2007

AbstractBackground. To assess whether survival or local control of early squamous cell carcinoma of the tonsil has been compromised by a moderate‐dose approach.Methods. Between 1970 and 1989, 185 patients with SCCa of the tonsil were seen at our institution. Fifty‐three patients with T1 (30) and T2 (23) lesions treated with definitive radiotherapy were reviewed. Median follow‐up was 60 months. The effects of total dose and site of the primary on survival and local regional control were analyzed.Results. Three‐year determinate survival was 77%. Mean total dose was 63.1 Gy. Site of the primary significantly affected survival (86% for fossa, 54% for pillars, p < 0.025). Local control at 2 years was 81% and was independent of dose ≥ 63 Gy or site of the primary. Grade 4 complications defined by the RTOG/EORTC Acute Morbidity criteria occurred in three patients.Conclusions. Tumor doses on the order of 63 Gy or less result in excellent local control and survival rates for T1 and T2 carcinomas of the tonsil. Local control rates are better for fossa lesions than for pillar lesions. © 1995 Jons Wiley & Sons, Inc.
An application of the unfolding model to explain turnover in a sample of military officers
Authors: Holt Daniel T. , Rehg Michael T. , Lin Jeffrey H. S. , Miller Jennifer 
Published: February 2007

AbstractQuestionnaire data from 182Air Force officers who had voluntarily separated from the service were used to test Lee and Mitchell's (1994) unfolding model of voluntary turnover. Specifically, Lee and Mitchell predict five distinct paths to voluntary turnover, explaining the sequence of deliberate and impulsive decisions individuals make as they choose to leave organizations, where individuals interpret an organizational event, assess their relation to the workplace, evaluate options, and enact a response. Results indicate that 47% of the participants followed those five paths. Model modifications were made that reflect the unique nature of military service where members have preexisting plans to leave the service after a defined period or event.These modifications capture an additional 36% to explain 83% of the turnover decisions.The implications of these findings are addressed. ©2007 Wiley Periodicals, Inc.
Modulation of zinc release from bioactive sol–gel derived SiO2‐CaO‐ZnO glasses and ceramics
Authors: Jaroch D.B. , Clupper D.C. 
Published: February 2007

AbstractZinc is an essential trace element which may be effective in promoting hard tissue healing. Glasses in the SiO2‐CaO‐ZnO system were synthesized via sol–gel methods. Using a constant silica content (70 mol %), the ratio of Ca to Zn was varied (1.5, 3.5, or 6.5), as was the stabilization temperature (650, 750, or 850°C), to examine such effects on the bioactive response and zinc release in simulated body fluid (SBF). XRD revealed the development of CaSiO3 and Ca2ZnSi2O7 crystalline phases during stabilization at 850°C only. N2 adsorption analysis determined that the specific surface area (BET) varied between 14 and 179 m2/g and was dependent on composition and stabilization temperature, as was the average initial pore size (51–125 Å). The formation of hydroxycarbonate (HCA) and amorphous calcium phosphate (ACP) was observed at 14 days for samples stabilized at 650 or 750°C. Only ACP layers were observed on such samples prior to 14 day. Relative to the Ca levels at 14 day (60–485 μg/ml), Zn levels in solution were relatively low (0.06–1.18 μg/ml). EDX and ICP data suggested that released Zn was incorporated into the forming calcium phosphate reaction layer, thereby preventing concentrations of the essential trace element from reaching potentially toxic levels. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res 2007
Evaluation of a parallel plate membrane plasma exchange system
Authors: Buffaloe George W. , Erickson Ross R. , Dau Peter C. 
Published: February 2007

AbstractA new parallel plate membrane plasma exchange system (Centry TPE System) has been developed and clinically evaluated. A series of 27 consecutive plasma exchanges were performed on 14 patients with autoimmune diseases. Blood access was obtained by routine means identical to centrifugal procedures. The blood flow rate was 94±20 ml/min and plasma filtration rate was 37±9 ml/min, with an average patient hematocrit of 36%. The sieving coefficients for a wide range of plasma solutes including immunoglobulins, immune complexes, and lipids, clustered about 1.00, indicating nonselective plasma filtration. The average reduction in patient plasma solutes of 60 to 70% was in close agreement with the predicted value for unhindered plasma filtration. There was no appreciable loss of blood cells, as compared to a study with a centrifugal system showing a 56% reduction in circulating platelets. Complement activation measured by C3 conversion was undetectable in patient samples and either undetectable or minimal in plasma filtrate samples. The system was convenient to operate and problems were rare. No untoward patient effects attributable to the membrane system were observed. These results show that the parallel plate membrane plasma exchange system described in this report is capable of delivering safe, efficient plasma exchange.
Leukapheresis: Increasing the granulocyte yield with the fenwal CS‐3000
Authors: Loftus T. J. , White R. F. , Huestis D. W. 
Published: February 2007

AbstractBy premedicating the donor with 60 mg prednisone in divided doses and processing more donor blood at higher flow rates than those specified by the manufacturer, one can obtain high yields of granulocytes and platelets (mean of 3.3 × 1010 and 5.9 × 1011, respectively) with the Fenwal CS‐3000 blood cell separator. The steroid effect predominates over that of processing more blood. In the case of donors who are not stimulated by steroid, processing 10 L of donor blood at flow rates of 60 to 70 ml/minute results in a significantly improved yield of granulocytes (mean of 2.2 × 1010 as opposed to 1.4 in the case of 7 L) and of platelets (6.1 × 1011 versus 4.7). The concentrates contain about 50 to 60% less lymphocytes when donors are given steroid. With these modifications, the leukapheresis can still be accomplished in less than three hours and with minimal adverse effects on the donors.
Alternate dosage regimens for high molecular weight hydroxyethyl starch
Authors: Rock G. , McCombie N. 
Published: February 2007

AbstractSix percent high molecular weight hydroxyethyl starch (HES) was used in the standard 500 nil dose and in various decreased doses to assess the efficacy of alternate dosage regimens for granulocyte procurement. When used in full strength, yields of 0.57±.15 × 1010per liter of blood processed (LBP) were obtained. When HES was used on only the first three passes, the subsequent three passes, done with Anticoagulant Citrate Dextrose Solution USP Formula A (ACD‐A); Fenwal Laboratories, Deerfield, IL), reduced the yield to 0.14 ± .06 × 1010/LBP. Reversing this procedure gave yields of 0.06 ± .05 × 1010/LBP (without HES) and 0.49 ± 0.36 × 1010/LBP when HES was added during the next three passes. When the HES dose was reduced to half‐strength on the second consecutive day of leukapheresis, the granulocyte yields were reduced from 0.57 ±.15 × 1010/LBP to 0.42 ±.07 × 1010/LBP. Use of half‐strength HES on virgin donors gave yields of only 0.35 ± .39 × 1010/LBP. Infusion of the entire 500 ml dose of HES 1/2 hour prior to the procedure produced low yields of 0.20 ± .12 × 1010/LBP, indicating that HES must be present during the centrifugation and separation procedure in order to enhance yields. The data suggest that alternate dosage regimens of this form of HES are not advisable and that optimal yields are produced when 500 ml of the six percent solution is used during the collection procedure.
Lymphocyte subpopulations of plateletapheresis products collected with the fenwal CS‐3000 cell separator
Authors: Mintz Paul D. , Normansell David E. , Innes Donald J. 
Published: February 2007

AbstractTo determine whether any lymphocyte subset is preferentially harvested and transfused as a consequence of plateletapheresis with the Fenwal CS‐3000 Blood Cell Separator, the proportions of lymphocyte subpopulations in platelet concentrates were compared to their proportions in the donors' peripheral venous blood immediately prior to platelet collection. There was no difference in the proportion of B cells (surface immunoglobulin positive), T cells (OKT3 positive), helper/inducer T cells (OKT4 positive), suppressor/cytotoxic T cells (OKT8 positive), and natural killer cells (Leu 7 positive) in the donors' peripheral venous blood and the plateletapheresis product. Thus, although previous studies have demonstrated the ability to separate lymphocyte subpopulations by density centrifugation and velocity sedimentation, plateletapheresis with the CS‐3000 harvests the lymphocyte subpopulations studied in the same proportions in which they circulate in donors' peripheral venous blood.
Multiple plasma exchanges successfully maintain a young adult patient with crigler‐najjar syndrome type I
Authors: Ahmed P. , Pratt A. , Land V. J. , Flye M. W. , Chaplin H. 
Published: February 2007

AbstractPlasmapheresis has been shown to reduce total and free bilirubin levels in acute exacerbations of Crigler‐Najjar syndrome, type 1 (CNS‐TI), but its effectiveness in long‐term management has not been reported. An 18‐year‐old (yo) male with CNS‐TI, who required prolonged daily high‐intensity phototherapy to prevent cerebral nervous system symptoms, developed increasingly frequent bouts of confusion, nausea, and vomiting associated with free bilirubin concentrations (fbcs) >10–15 nmol/L. Pending consideration of orthotopic liver transplantation, plasma exchange (∼3 liters per procedure) was begun in 12/84 using the IBM/COBE 2997 with 5% albumin as replacement fluid. Frequency of treatments was guided by twice weekly fbcs, with plasma exchange for fbc >10–15 nmol/L. Pre‐exchange and postexchange fbcs ranged from 27.5 to 11 nmol/L and 9.2 to 2 nmol/L, respectively. Seventy‐two exchanges were performed over a 28 month period. Irreversible CNS damage did not occur, and the patient underwent successful liver transplantation in April of 1987, with complete correction of his metabolic disorder. He remains well 18 months following transplantation.
Minimal toxicity during protein a immunoadsorption treatment of malignant disease: An outpatient therapy
Authors: Snyder Harry W. , Henry David H. , Messerschmidt Gerald L. , Mittelman Abraham , Bertram Juergen , Ambinder Edward , Kiprov Dobri , Balint Joseph P. , MacKintosh F. Roy , Hamburger Max , Viola Michael V. , Fiore John , Louie James , Higby Donald J. , O'Brien Paul , Ainsworth Sterling , Fisher Lloyd D. , Perkins William , Jones Frank R. 
Published: February 2007

AbstractExtracorporeal removal or modulation of circulating immune complexes (CIC) from plasma of animals and humans with malignant disease may be associated with induction of immune‐mediated anti‐tumor responses. Immunoadsorption columns containing heat‐killed and formalin‐fixed Staphylococcus aureus or staphylococcal protein A have been used for this purpose but treatments have often been associated with cardiopulmonary toxicity. Recently, an immunoadsorption device containing highly purified protein A covalently attached to a silica matrix (PROSORBA© column) was used to treat 142 patients with refractory malignancies and 22 of 104 patients evaluated for anti‐tumor response had objectively measurable reduction in tumor burden. In contrast to earlier experience with other devices, the procedures used in this trial were well tolerated and could be performed on an outpatient basis. The most common side effects observed among 1,306 treatments were chills (28% of treatments), low grade fever (28%), and musculoskeletal pain (16%). Side effects were mild to moderate and required no treatment or only symptomatic treatment. Treatment schedules were interrupted due to side effects for only six patients and there were no treatment‐related deaths. Of 64 patients available for long‐term follow‐up evaluation (mean of 11 months), none exhibited evidence of long‐term treatment‐related side effects. None of the patient deaths in that period were associated with short or long‐term treatment‐related side effects. Protein A‐lica (PROSORBA© columns) can be used safely for development of further experimental treatments of malignant disease.