bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated Extraction of Stroke Severity from Unstructured Electronic Health Records using Natural Language Processing
Authors: Fernandes Marta , Westover M. Brandon , Singhal Aneesh B. , Zafar Sahar F. 
Published: March 2024

AbstractBACKGROUNDMulti-center electronic health records (EHR) can support quality improvement initiatives and comparative effectiveness research in stroke care. However, limitations of EHR-based research include challenges in abstracting key clinical variables from non-structured data at scale. This is further compounded by missing data. Here we develop a natural language processing (NLP) model that automatically reads EHR notes to determine the NIH stroke scale (NIHSS) score of patients with acute stroke.METHODSThe study included notes from acute stroke patients (>= 18 years) admitted to the Massachusetts General Hospital (MGH) (2015-2022). The MGH data were divided into training (70%) and hold-out test (30%) sets. A two-stage model was developed to predict the admission NIHSS. A linear model with the least absolute shrinkage and selection operator (LASSO) was trained within the training set. For notes in the test set where the NIHSS was documented, the scores were extracted using regular expressions (stage 1), for notes where NIHSS was not documented, LASSO was used for prediction (stage 2). The reference standard for NIHSS was obtained from Get With The Guidelines Stroke Registry. The two-stage model was tested on the hold-out test set and validated in the MIMIC-III dataset (Medical Information Mart for Intensive Care-MIMIC III 2001-2012) v1.4, using root mean squared error (RMSE) and Spearman correlation (SC).RESULTSWe included 4,163 patients (MGH = 3,876; MIMIC = 287); average age of 69 [SD 15] years; 53% male, and 72% white. 90% patients had ischemic stroke and 10% hemorrhagic stroke. The two-stage model achieved a RMSE [95% CI] of 3.13 [2.86-3.41] (SC = 0.90 [0.88-0. 91]) in the MGH hold-out test set and 2.01 [1.58-2.38] (SC = 0.96 [0.94-0.97]) in the MIMIC validation set.CONCLUSIONSThe automatic NLP-based model can enable large-scale stroke severity phenotyping from EHR and therefore support real-world quality improvement and comparative effectiveness studies in stroke.
Integrating single-cell transcriptomics with Artificial Intelligence reveals pan-cancer biomarkers of brain metastasis
Authors: Lusby Ryan , Carl Sarah , Tiwari Vijay K. 
Published: March 2024

ABSTRACTBrain metastasis (BrM) represents a devastating complication across various cancer types, posing as a significant contributor to global morbidity and mortality. Hence, identifying robust biomarkers for early detection across various cancer types with a propensity for BrMs and their therapeutic targeting is highly timely and critical. In this study, we leveraged single-cell RNA sequencing (scRNA-seq) data from six cancer types and combined with convolutional neural network (CNN)-based ScaiVision algorithm to identify a pan-cancer BrM signature that achieved remarkable accuracy in distinguishing BrM from primary tumour cells. Further analysis revealed that the BrM signature was not only prognostic but also detectable in bulk RNA-seq data, providing a stratification tool for patients with high or low metastatic potential. Strikingly, this signature was detected at high levels in the tumour educated platelets, showcasing its potential as a minimally invasive tool for metastasis detection. High BrM signature scores were associated with reduced patient survival, particularly in cancers prone to brain metastasis, such as renal and colorectal cancers. Further analysis uncovered VEGF signalling as a central driver of communication networks in high BrM-scored cells. Accordingly, drug repurposing analysis identified Pazopanib as a candidate for targeting highly metastatic cells that disrupts VEGF signalling networks, and potentially impedes brain metastatic progression in multiple cancer types. This study presents a comprehensive pan-cancer BrM signature with clinical implications for early detection and therapeutic intervention in brain metastasis.
Bank liquidity creation, loan concentration and liquidity risk: a comparative analysis of dual banking system
Authors: Akram Hassan , Hushmat Adnan 
Published: March 2024

Purpose
Keeping in view the robust growth of Islamic banking around the globe, this study aims to comparatively analyze the association between liquidity creation and liquidity risk for Islamic banks (IBANs) and conventional banks (CBANs) in Pakistan and Malaysia over a period of 2004–2021. The moderating role of bank loan concentration on the aforementioned relationship is also studied.

Design/methodology/approach
Regression estimation methods such as fixed effect, random effect and generalized least square are deployed for obtaining results. Liquidity creation Burger Bouwman measure (cat fat and noncat fat) and Basel-III liquidity risk measure (liquidity coverage ratio) are also used.

Findings
The results give us insight that liquidity creation is positively and significantly related to liquidity risk in both IBANs and CBANs of Pakistan and Malaysia. This relationship has been moderated negatively (reversed) and significantly by credit concentration showing the importance of risk management and loan portfolio concentration.

Practical implications
It is analyzed that during the process of liquidity creation, IBANs in Pakistan faced more liquidity risk for both on and off-balance sheet transactions in the presence of moderation of loan concentration than IBANs in Malaysia necessitating strategic policy-making for important aspects of liquidity risk management and loan concentration while creating liquidity.

Originality/value
Such studies comparing IBANs and CBANs comparison keeping in view liquidity creation, liquidity risk and loan concentration are either limited or nonexistent.
A study on site selection of wind power plant based on prospect theory and VIKOR: a case study in China
Authors: Zhao Hui , Wang Simeng , Lu Chen 
Published: March 2024

PurposeWith the continuous development of the wind power industry, wind power plant (WPP) has become the focus of resource development within the industry. Site selection, as the initial stage of WPP development, is directly related to the feasibility of construction and the future revenue of WPP. Therefore, the purpose of this paper is to study the siting of WPP and establish a framework for siting decision-making.Design/methodology/approachFirstly, a site selection evaluation index system is constructed from four aspects of economy, geography, environment and society using the literature review method and the Delphi method, and the weights of each index are comprehensively determined by combining the Decision-making Trial and Evaluation Laboratory (DEMATEL) and the entropy weight method (EW). Then, prospect theory and the multi-criteria compromise solution ranking method (VIKOR) are introduced to rank the potential options and determine the best site.FindingsChina is used as a case study, and the robustness and reliability of the methodology are demonstrated through sensitivity analysis, comparative analysis and ablation experiment analysis. This paper aims to provide a useful reference for WPP siting research.Originality/valueIn this paper, DEMATEL and EW are used to determine the weights of indicators, which overcome the disadvantage of single assignment. Prospect theory and VIKOR are combined to construct a decision model, which also considers the attitude of the decision-maker and the compromise solution of the decision result. For the first time, this framework is applied to WPP siting research.
Do nonfinancial reporting practices matter in SDG disclosure? An exploratory study
Authors: Erin Olayinka Adedayo , Olojede Paul 
Published: March 2024

Purpose
The Agenda 2030 have drawn a lot of interest in academic studies. This necessitates accounting research on nonfinancial reporting and sustainable development goals (SDG) disclosure in an under-investigated context. The purpose of this study is to examine the contribution of nonfinancial reporting practices to SDG disclosure by 120 companies from 12 African nations for the years 2016 to 2020.

Design/methodology/approach
The study uses a content analysis to gauge how much information are disclosed on SDG by the selected firms. The authors carried out content analysis using the global reporting initiative frameworks to determine the level of SDG disclosure across the companies by examining the selected nonfinancial reports.

Findings
Sustainability reports account for 50% of such SDG disclosure making it the highest. This is followed by corporate social responsibility report which accounts for 23%, while environmental reports account for 20% and Chairman’s statement accounts for 7%. The result is expected since corporate sustainability report has been the major channel for disclosing activities relating to social and governance issues in recent times.

Practical implications
The results of this study demand that corporate entities in Africa take responsibility for their actions and exert significant effort to achieve the SDG. While the government has the main responsibility, corporate entities must support the SDG to be realized.

Originality/value
To the best of the authors’ knowledge, this study is one of the few studies that examines nonfinancial reporting practices with a focus on SDG disclosure. In addition, this study offers novel insight into how accounting research contributes to nonfinancial reporting practices and SDG disclosure.
Commentary on “Collective effort to enhance the quality of research evidence in intellectual and developmental disabilities: a case study of an academic-practice network”
Authors: Cameron Michael J. , Shahin Jenifer , Lockerman Nicole 
Published: March 2024

Purpose
This paper aims to endorse and elaborate on the recommendations put forward by the Sharland Foundation Developmental Disabilities Applied Behavioural Research and Impact Network (SF-DDARIN), emphasising their significance in the field of developmental disabilities.

Design/methodology/approach
This paper outlines a specific point of view. The first section focuses on integrating developmental theory and advanced technology in interventions for developmental disabilities. Subsequently, the commentary explores virtual reality (VR) and generative artificial intelligence (AI) for enhancing social skills and personalising support. Finally, the piece highlights innovations like SocialWise VR and Custom Generative Pre-Trained Transformers in aligning interventions with developmental stages.

Findings
Technologies like VR and generative AI hold vast potential to revolutionise how clinicians provide timely and relevant knowledge to individuals with developmental disabilities.

Research limitations/implications
This is strictly a commentary.

Practical implications
Availability of technology.

Social implications
Both VR and generative AI will impact service delivery in a meaningful way.

Originality/value
The paper advocates for incorporating these technologies into SF-DDARIN's approach, emphasising their potential to revolutionise evidence-based interventions in developmental disabilities.
Understanding digital consumer culture in Indonesia: a case study on youth community in Jakarta using an actor-network theory approach
Authors: Ekklesia Jan Mealino 
Published: March 2024

Purpose
This study aims to examine digital consumer culture and behavior in the community, namely, 180° Movement Digital Training Center (DTC), in Jakarta, Indonesia. It aims to describe the dynamics of digital consumer culture in contemporary society, particularly as experienced by the youth community in Jakarta in the context of socio-technology relations and incorporates it into the diagram of digital consumer culture network.

Design/methodology/approach
This research uses a constructivist qualitative approach and socio-technical relation analysis through actor-network theory and digital consumer culture.

Findings
The study finds that the individual model of digital consumption is constructed through the process of problematization, interessement, enrollment and mobilization of individuals. It generates a culture in which consumers are constantly up to date with high-intensity information, but within increasingly shorter timeframes, while also considering principles of affordability, needs, desires and satisfaction. The network of digital consumer culture construction among informants is peculiar and unstable.

Research limitations/implications
The study of digital consumer culture within the 180° Movement DTC community highlights how consumer behaviors of its members are facilitated and interconnected within a digital cultural network. However, this research is constrained by the dialectical interplay between Christian principles and the emerging values of consumer culture, a result of the scarcity of theoretical resources and information. This study also provides a specific contribution as a foundation for mapping the volatile digital consumer culture for researchers.

Practical implications
Understanding the socio-technological relationships and consumption behavior of the youth community could help digital platforms tailor their services more effectively. It could also guide the 180° Movement DTC in developing programs that resonate with the youth, bridging the gap between the physical and virtual realms. Ultimately, this could lead to a more engaged and digitally literate society.

Social implications
This study contributes to a broader societal understanding of how digital technology is shaping consumer behavior and identity within youth communities, which can influence social dynamics and interactions. It provides insights into the potential social impacts of digital technology, such as changes in relationships, communication patterns and self-perception, informing societal discourse on digital culture.

Originality/value
In addition to presenting socio-technological analysis on Indonesian consumer culture using actor-network theory, some also show that studies on digital connectivity ambivalence that concern the relationship between humans as actors and non-humans as actors have become one of the popular sociology studies at present.
Interferon inducible guanylate‐binding protein 1 modulates the lipopolysaccharide‐induced cytokines/chemokines and mitogen‐activated protein kinases in macrophages
Authors: Kumar Ravindra , Kushawaha Pramod Kumar 
Published: March 2024

AbstractGuanylate‐binding proteins (GBPs) are a family of interferon (IFN)‐inducible GTPases and play a pivotal role in the host immune response to microbial infections. These are upregulated in immune cells after recognizing the lipopolysaccharides (LPS), the major membrane component of Gram‐negative bacteria. In the present study, the expression pattern of GBP1–7 was initially mapped in phorbol 12‐myristate 13‐acetate‐differentiated human monocytes THP‐1 and mouse macrophages RAW 264.7 cell lines stimulated with LPS. A time‐dependent significant expression of GBP1–7 was observed in these cells. Moreover, among the various GBPs, GBP1 has emerged as a central player in regulating innate immunity and inflammation. Therefore, to study the specific role of GBP1 in LPS‐induced inflammation, knockdown of the Gbp1 gene was carried out in both cells using small interfering RNA interference. Altered levels of different cytokines (interleukin [IL]‐4, IL‐10, IL‐12β, IFN‐γ, tumor necrosis factor‐α), inducible nitric oxide synthase, histocompatibility 2, class II antigen A, protein kinase R, and chemokines (chemokine (C‐X‐C motif) ligand 9 [CXCL9], CXCL10, and CXCL11) in GBP1 knockdown cells were reported compared to control cells. Interestingly, the extracellular‐signal‐regulated kinase 1/2 mitogen‐activated protein (MAP) kinases and signal transducer and activator of transcription 1 (STAT1) transcription factor levels were considerably induced in knockdown cells compared to the control cells. However, no change in the level of phosphorylated nuclear factor‐kB, c‐Jun, and p38 transcription factors was observed in GBP1 knockdown cells compared to the control cells. This study concludes that GBP1 may alter the expression of cytokines, chemokines, and effector molecules mediated by MAP kinases and STAT1 transcription factors.
Macroinvertebrate and environmental responses to dredging and submerged macrophytes transplantation
Authors: Fu Hong , Xu Jun , García Molinos Jorge , Zhang Huan , Wang Huan , Zhang Min , Klaar Megan , Brown Lee E. 
Published: March 2024

AbstractEutrophication of freshwater ecosystems is a global problem, but restoration can be difficult due to ongoing problems relating to water pollution, sedimentary nutrient stores and altered aquatic biodiversity. Mitigation of Eutrophication is often conducted alongside transplantation of submerged macrophytes and dredging, but knowledge of ecosystem response to post‐dredging transplantation of submerged macrophytes is limited.We report a long‐term (2008–2018) in situ monitoring study to evaluate the effects of different restoration measures: dredging only (Dredged) and dredged with post‐transplantation of submerged macrophytes (Dredged with macrophytes) conducted in five subtropical eutrophic lakes, Taihu basin. Water and sediment nutrients, bloom‐forming algaeMicrocystisand macroinvertebrate were monitored every 2 years for each treatment and compared with reference areas (Control) established in unrestored parts of the same lake.Dredging only decreased sediment nutrients (e.g. carbon, phosphorus) significantly; however, this effect diminished about 5 years later. Dredged with macrophytes had a stronger, longer lasting positive effect on water quality than dredged alone. Disturbance caused by dredging (without macrophytes transplantation) decreased the biomass ofMicrocystis, while transplantation of macrophytes shortly after dredging did not contribute to the decreasing ofMicrocystisbiomass. The biomass ofMicrocystisin Dredged with macrophytes areas was always similar to Control over the period of our monitoring.A positive effect of submerged macrophytes transplantation post‐dredging was found for macroinvertebrate abundance and diversity: Dredged with macrophytes areas had significantly higher macroinvertebrate biomass and richness than Dredged areas after 9 years' recovery. Macroinvertebrate richness in Dredged with macrophytes areas nearly doubled compared to Control, while Dredged areas were just restored to Control levels.Synthesis and applications: Our study provides an long‐term field monitoring with new findings about the benefits and caution of submerged macrophytes transplantation post‐dredging and the effect of partial restoration, which could inform eutrophic waterbody restoration schemes.
Replicable Patent Indicators Using the Google Patents Public Datasets
Authors: Abi Younes George , de Rassenfosse Gaétan 
Published: March 2024

AbstractRecognising the increasing accessibility and importance of patent data, the article underscores the need for standardised and transparent data analysis methods. We illustrate the construction and relevance of commonly used patent indicators derived from Google Patents Public Datasets. The indicators range from citation counts to more advanced metrics like patent text similarity. The BigQuery code is available in an open Kaggle notebook, explaining operational intricacies and potential data issues. By providing clear, adaptable queries and emphasising transparent methods, this article hopes to contribute to the standardisation and accessibility of patent analysis, offering a valuable resource for researchers and practitioners alike.
The Limits of ‘Opportunity’: Is There a Clear Labour or Conservative View of Social Mobility?
Authors: Maslen Joseph 
Published: March 2024

AbstractThis article considers the relationship between views of social mobility in British politics, identifying four competing views in government statements, political news stories and opinion pieces. The two established views are the Blairite liberal view, which seeks to widen entry into the ‘playing field’ of educational ‘opportunity’, and its companion bourgeois view, protecting the acclaim given to elite educational experiences. Against these established views are two insurgent views: a (politically ignored) socialist view and a ‘postliberal’ view introduced into the Social Mobility Commission under the chairship of the loosely Conservative‐aligned Katharine Birbalsingh. On the right, the postliberal and bourgeois views explicitly clash. On the left, with the socialist view dormant, the postliberal view is assimilated by Labour almost as a socialism substitute, appearing in turn with the Blairite liberal view in Labour rhetoric. The result is, respectively on right and left, disharmony and incoherence in the meaning of social mobility.
Shrinking in the dark: Parallel endosymbiont genome erosions are associated with repeated host transitions to an underground life
Authors: Beasley‐Hall Perry G. , Kinjo Yukihiro , Rose Harley A. , Walker James , Foster Charles S. P. , Kovacs Toby G. L. , Bourguignon Thomas , Ho Simon Y. W. , Lo Nathan 
Published: March 2024

AbstractMicrobial symbioses have had profound impacts on the evolution of animals. Conversely, changes in host biology may impact the evolutionary trajectory of symbionts themselves. Blattabacterium cuenoti is present in almost all cockroach species and enables hosts to subsist on a nutrient‐poor diet. To investigate if host biology has impacted Blattabacterium at the genomic level, we sequenced and analyzed 25 genomes from Australian soil‐burrowing cockroaches (Blaberidae: Panesthiinae), which have undergone at least seven separate subterranean, subsocial transitions from above‐ground, wood‐feeding ancestors. We find at least three independent instances of genome erosion have occurred in Blattabacterium strains exclusive to Australian soil‐burrowing cockroaches. These shrinkages have involved the repeated inactivation of genes involved in amino acid biosynthesis and nitrogen recycling, the core role of Blattabacterium in the host‐symbiont relationship. The most drastic of these erosions have occurred in hosts thought to have transitioned underground the earliest relative to other lineages, further suggestive of a link between gene loss in Blattabacterium and the burrowing behavior of hosts. As Blattabacterium is unable to fulfill its core function in certain host lineages, these findings suggest soil‐burrowing cockroaches must acquire these nutrients from novel sources. Our study represents one of the first cases, to our knowledge, of parallel host adaptations leading to concomitant parallelism in their mutualistic symbionts, further underscoring the intimate relationship between these two partners.
A global assessment of hemostatic function of healthy allogeneic stem cell donors undergoing apheresis by rotational thromboelastometry
Authors: Cilek Neslihan , Ugurel Elif , Eren Ozgur Can , Yalcin Ozlem , Akay Olga Meltem 
Published: March 2024

AbstractIntroductionPeripheral blood stem cell (PBSC) collection via apheresis requires the administration of granulocyte colony‐stimulating factor (filgrastim) to stem cell donors. Several reports have shown that filgrastim administration and apheresis procedure induce a hypercoagulable state across PBSC collection, which might predispose certain donors to thrombotic complications.MethodsWe evaluated the hemostatic functions of healthy allogeneic stem cell donors by rotational thromboelastometry (ROTEM). Blood samples from healthy donors (n = 30) were collected at defined time points: before filgrastim (baseline), on the day of apheresis before and after the procedure, and 1 week after apheresis.ResultsThe results indicated that hemostatic changes are temporary since all parameters in both EXTEM and INTEM assays are restored to their initial values 1 week after the apheresis.ConclusionWe concluded that stem cell apheresis does not induce a hypercoagulable state in healthy donors. This is the first study evaluating the hemostatic functions of stem cell donors by ROTEM.