bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penguatan Pengetahuan Kader Posbindu – PTM (Penyakit Tidak Menular) Dalam Memanfaatkan Terapi Herbal Dan Massage Di Puskesmas Martapura Barat
Authors: Pertiwiwati Endang , Wibowo Hery , Salsabila Yusyifa , Laila Nur Syifa 
Published: March 2024

Peningkatan prevelensi penyakit tidak menular (PTM) menjadi ancaman serius dalam pembangunan, karena mengancam pertumbuhan ekonomi nasional.salah satu permasalahan yang dihadapi saat ini dalam pembangunan kesehatan adalah beban ganti penyakit., Dalam menghadapi masalah tersebut perlu adanya Kader Posbindu. karena keberadaan kader kesehatan menjadi salah satu bentuk pemberdayaan masyarakat yang dapat mendorong partisipasi masyarakat dalam mewujudkan masyarakat sehat. Kader Posbindu merupakan garda terdepan pelaksanaan pencegahan dan pengendalian penyakit tidak menular. Kegiatan kader lebih mengutamakan upaya preventif dan promotif. Agar bisa menjalankan itu, kader kesehatan perlu mendapatkan penguataan pengetahuan, pelatihan dan pendampingan dalam peningkatan kesehatan masyarakat terutama lansia yang berkunjung ke posbindu. Tujuan kegiatan ini adalah untuk meningkatkan pengetahuan dan keterampilan kader Posbindu melalui pelatihan dan pendampingan memanfaatkan tanaman sirih merah, dan terapi massage untuk Meningkatkan status kesehatan para lansia yang berkunjung di Posbindu. Keberhasilan ini berupa munculnya kesadaran pentingnya meningkatkan Kesehatan dimasyarakat salah satunya peran kader posbindu selaku garda terdepan dalam penggerak Posbindu PTM yang tersebar di 16 posbindu di wilayah Martapura Barat. Setelah dilakukan kegiataan kepada kader posbindu didapatkan peningkatan pengetahuan dari 21 orang kader posbindu. Hasil akhir dari nilai pengetahuan kader posbindu mdidapatkan 89,00 sudah lebih 80% pengetahuan yang ditargetkan tercapai
Pendampingan dari Diagnosis Implementasi Green House Level Medium Sebagai Solusi Pengentasan Kemiskinan Ekstrim
Authors: Heryani Hesty , Hakim Arif Rahman , Saputra Panggih Prabowo Rona 
Published: March 2024

Kebutuhan dasar bagi masyarakat harus terpenuhi dengan pengeluaran melebihi Rp. 10.739/orang/hari. Kondisi demikian menyatakan bahwa Indonesia pada Tahun 2024 sudah bebas dari kemiskinan ekstrim, akan tetapi kondisi lahan yang dimiliki masyarakat sangat terbatas bahkan tidak ada, terjadi perubahan iklim drastis, lahan marginal yang tidak subur serta harga produk hortikultura yang murah dan mudah rusak. Tujuan Pengabdian pada Masyarakat adalah mendesiminasikan Teknologi Green House Level Medium dalam Pengembangan Komoditas Hortikultura dengan pengembangan produk hortikultura melalui pelatihan dan bimbingan sehingga dapat memasuki pasar modern seperti pasar SNI 8152: 2021 dan pasar pusat perbelanjaan modern lainnya yang berada di Mall. Metode yang dikembangkan di masyarakat dengan pelatihan mendesain green house level medium, melakukan pelatihan dan pendampingan teknik budidaya hortikultura dalam green house, pelatihan dan pendampingan dalam membuat formula nutrisi, melakukan kontrol nutrisi saat proses produksi berjalan serta penangan pasca panen hingga dapat masuk pasar modern, serta kuesioner evaluasi kegiatan. Hasil yang diperoleh dalam dua replika penanaman, Kelompok UMKM Target dapat menyerap transfer teknologi mencapai 88,3%, pemahaman konsep teknologi berkelanjutan mencapai 98%, kemampuan dalam mendesain green house level medium mencapai 99% serta sudah mampu memformula nutrisi, menyemai, menanam, memelihara hingga panen dan mempersiapkan ke Pasar Moderen. Pelatihan dan pendampingan pada masyarakat demikian merupakan solusi yang ditawarkan pada kondisi ketersediaan lahan minim, perubahan iklim drastis, kondisi tanah marginal serta produk hortikultura organik yang sulit dapat menembus pasar modern.
Item Response Theory Validation of the Forgotten Joint Score for Persons Undergoing Total Knee Replacement
Authors: Khatri Chetan , Harrison Conrad J. , Clement Nick D. , Scott Chloe E.H. , MacDonald Deborah , Metcalfe Andrew J. , Rodrigues Jeremy N. 
Published: March 2024

Background:
The Forgotten Joint Score (FJS), a commonly used patient-reported outcome measure, was developed without fully confirming assumptions such as unidimensionality (all items reflect 1 underlying factor), appropriate weighting of each item in scoring, absence of differential item functioning (in which different groups, e.g., men and women, respond differently), local dependence (pairs of items are measuring only 1 underlying factor), and monotonicity (persons with higher function have a higher score). We applied item response theory (IRT) to perform validation of the FJS according to contemporary standards, and thus support its ongoing use. We aimed to confirm that the FJS reflects a single latent trait. In addition, we aimed to determine whether an IRT model could be fitted to the FJS.

Methods:
Participants undergoing primary total knee replacement provided responses to the FJS items preoperatively and at 6 and 12 months postoperatively. An exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and Mokken analysis were conducted. A graded response model (GRM) was fitted to the data.

Results:
A total of 1,774 patient responses were analyzed. EFA indicated a 1-factor model (all 12 items reflecting 1 underlying trait). CFA demonstrated an excellent model fit. Items did not have equal weighting. The FJS demonstrated good monotonicity and no differential item functioning by sex, age, or body mass index. GRM parameters are reported in this paper.

Conclusions:
The FJS meets key validity assumptions, supporting its use in clinical practice and research. The IRT-adapted FJS has potential advantages over the traditional FJS: it provides continuous measurements with finer granularity between health states, includes individual measurement error, and can compute scores despite more missing data (with only 1 response required to estimate a score). It can be applied retrospectively to existing data sets or used to deliver individualized computerized adaptive tests.

Level of Evidence:
Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.
AOA Critical Issues Symposium: Gun Violence as a Public Health Crisis
Authors: Miller Anna N. , Strelzow Jason A. , Sakran Joseph V. , Ficke James R. 
Published: March 2024

Abstract:
Gun violence is an epidemic throughout the United States and is increasing around the world—it is a public health crisis. The impact of gun violence is not limited to the victims (our patients); it also extends to the physicians and caregivers who are taking care of these patients every day. Even more broadly, gun violence affects those living and going to work in potentially dangerous environments. The “vicarious trauma” that is experienced in these situations can have long-term effects on physicians, nurses, and communities. Importantly, socioeconomic disparities and community deprivation strongly correlate with gun violence. Systemic factors that are deeply ingrained in our society can increase concerns for these underrepresented patient populations and cause increased stressors with substantial health consequences, including delayed fracture-healing and poorer overall health outcomes. It is incumbent on us as physicians to take an active role in speaking up for our patients. The importance of advocacy efforts to change policy (not politics) and continue to push for improvement in the increasingly challenging environments in which patients and physicians find themselves cannot be overstated. Multiple national organizations, including many orthopaedic and general surgery associations, have made statements advocating for change. The American College of Surgeons, in collaboration with many other medical organizations, has supported background checks, registration, licensure, firearm education and training, safe storage practices, red flag laws, addressing mental health issues, and more research to better inform an approach going forward and to address the root causes of violence. We encourage the orthopaedic surgery community to stand together to protect each other and our patients, both physically and mentally, with agreement on these principles.
Synergistic Influence of Non-Thermal Plasma and Hydrogen Peroxide on Oxidative Desulfurization (ODS) of Model Fuel
Authors: Abdullah Noor M. , Hussien Hussien Q. , Jalil Rana R. 
Published: March 2024

تتضمن إزالة الكبريت إزالة مركبات الكبريت العضوية من زيوت الوقود. في هذه الدراسة، تم استخدام تقنية البلازما اللاحرارية وتقنية البلازما بمساعدة بيروكسيد الهيدروجين لاكسدة الوقود المحتوي على مركبات من benzothiophene و dibenzothiophene.
تم إجراء تفاعل الأكسدة باستخدام منظومة dielectric barrier discharge لتوليد بلازما غير حرارية. النتائج أظهرت ان تقنية البلازما ومزيج من البلازما مع بيروكسيد الهيدروجين معًا لأكسدة BT و DBT. تتبعان pseudo-first-order reaction وأن كفاءة الإزالة للبلازما 93.78٪ مقارنة مع مزيج البلازما وبيروكسيد الهيدروجين معًا والتي بلغت 95.12٪. هذا الاختلاف في الكفاءة لا يشكل فارقا اذا ما اخذ بنظر الاعتبار الناحية الاقتصادية (استهلاك المواد الكيميائية) ، حيث يمكن الاكتفاء بتقنية البلازما.
A New Invariant Regarding Irreversible k-Threshold Conversion Processes on Some Graphs
Authors: Kassem Ali , Mahfud Suhail , Shaheen Ramy 
Published: March 2024

تشكل عملية انتشار التحول غير العكوس ذو العتبة k في بيان ما نوعاً خاصاً من عمليات الانتشار البيانية والتي تهتم بشكل خاص بدراسة انتشار تغير في حالة رؤوس للبيان انطلاقاً من مجموعة اختيارية من رؤوسه حيث يتحقق انتشار التحول إلى الرؤوس المجاورة وفقاً لقاعدة تحول محددة مسبقاً. إن عملية انتشار التحول غير العكوس ذو العتبة k في البيان هي عملية تكرارية تدرس انتشار تغير أحادي الاتجاه (من الحالة 0 إلى الحالة 1) على . تبدأ العملية باختيار مجموعة ، ومن أجل كل خطوة فإن تنتج عن بإضافة جميع الرؤوس التي تجاور k رأسا على الأقل من إلى . تدعى بذرة عملية التحول غير العكوس ذو العتبة k وإذا تحقق أن من أجل قيمة ما ، عندئذ تسمى مجموعة تحول غير عكوس ذو عتبة انتشار k (IkCS) للبيان . عدد التحول غير العكوس ذو عتبة الانتشار k للبيان (يرمز له ) هو عدد عناصر أصغر IkCS للبيان . في هذه الورقة البحثية نقوم بتعريف معامل جديد يسمى زمن التحول غير العكوس ذو عتبة الانتشار k (نرمز له بـ ) والذي يقيس أقل عدد ممكن من الخطوات التي تحتاجها مجموعة IkCS أصغرية لنشر التحول إلى كافة رؤوس البيان. ونقوم بدراسة لبعض البيانات الخاصة البسيطة مثل المسارات والحلقات والبيان النجمي، كما نقوم أيضاً بإيجاد و للجداء المباشر لمسار وحلقة (والذي يرمز له بالرمز ) وذلك من أجل بعض قيم و و . كذلك نوجد للبيان السلمي من أجل وأي قيمة عشوائية لـ .
Fixed Point Results for Almost Contraction Mappings in Fuzzy Metric Space
Authors: Sabri Raghad I. , Ahmed Buthainah A. A. Ahmed 
Published: March 2024

في بعض المسائل الرياضية والحاسوبية والاقتصادية والنمذجة، يكون وجود حل لمشكلة نظرية أو مشكلة في العالم الحقيقي مرادفًا لوجود نقطة صامدة (Fp) لدالة مناسبة. وبالتالي، فأن نظرية النقطة الصامدة Fp تلعب دورًا أساسيًا في مجموعة واسعة من السياقات الرياضية والعلمية. تعتبر نظرية النقطة الصامدة Fp في حد ذاتها مزيجًا مذهلاً مكون من التحليل (التحليل الصرف والتحليل التطبيقي)، والهندسة، والطوبولوجيا. لقد أظهرت السنوات الأخيرة أن نظرية النقطة الصامدة Fp هي أداة قوية ومفيدة للغاية في دراسة الحالات غير الخطية. تهتم نظريات النقطة الصامدة Fp بدالة f من المجموعة X الى المجموعة X نفسها والتي في ظل ظروف معينة، فأنها تسمح بوجود نقطة صامدة Fp ، بعبارة اخرى انه بمعنى لكل نقطة x موجودة في المجموعة X (x∈X) بحيث أن f(x)=x . يقدم هذا العمل ويثبت نظرية النقطة الصامدة Fp لأنواع مختلفة من دوال الانكماش في الفضاء المتري الضبابي (FM-space) والتي تسمى بدالة الانكماش القريبة ودالة الانكماش الضعيفة القريبة ( Ψ̃ ,Φ̃). في البداية، تم التذكير بمفهوم الفضاء المتري الضبابي(FM-space) وبعض المصطلحات المستخدمة في الإطار الضبابي. ثم بعد ذلك تم اعطاء مفهوم دالة المحاكاة. يتم استخدام مفهوم دالة المحاكاة هذا لتقديم تعريف دالة الانكماش Z̃ القريبة في إطار الفضاء المتري الضبابي. بالإضافة إلى ذلك، لقد تم استخدام هذا المفهوم(دالة الانكماش Z̃ القريبة) لبرهان وجود النقطة الصامدة ووحدانية النقطة الصامدة لهذا النوع من الدوال.ثم بعد ذلك تم تقديم فكرة دالة الانكماش الضعيفة القريبة ( Ψ̃ ,Φ̃) في إطار الفضاء المتري الضبابي(FM-space) ، بالإضافة إلى تقديم نظرية النقطة الصامدة Fp لهذا النوع من من الدوال. وفي نهاية البحث تم تقديم بعض الأمثلة لدعم النتائج.
In vitro and in vivo experimental investigation Of TSRP reverses imatinib resistance through the PI3K / Akt pathway in chronic myeloid leukemia
Authors: He Ying , Ding Jiyuan , Liu Liqin , Chen Jiajun , Zhong Hong , Li Changyu , XU Xiaofeng 
Published: March 2024

Abstract
Chronic myelogenous leukemia (CML) is a malignant tumor of the blood system, so far there is no effective cure. Imatinib (IM), as the first-line drug for the clinical targeted treatment of CML, has some limiting factors such as drug resistance and relapse, and drug resistance has also emerged in combination with other drugs. At present, traditional Chinese medicine combined with targeted drugs in the treatment of tumor is a research hotspot. The total saponin (TSRP) of the Chinese herb Citraria sinensis has an effective anti-tumor activity. Our previous in vitro experiments showed that TSRP can effectively inhibit the proliferation and promote apoptosis of CML cells K562, suggesting that TSRP can effectively reverse the drug resistance of IM, but the mechanism of drug resistance remains unclear. Studies have shown that the PI3K/AKT pathway is the main activation pathway of IM secondary resistance, and is considered to be an innovative therapeutic strategy for targeted cancer treatment, which may be an important mechanism of IM resistance. This project aims to reveal the possible mechanism of TSRP reversing IM resistance through PI3K/AKT signaling pathway through both in vitro and in vivo experiments, providing experimental basis for TSRP combined with IM treatment of CML.
Prognostic value and immune status of AIM2 in skin cutaneous melanoma
Authors: Long Yong Sheng , Xu Jing , Wang Yu Mao , Chen Wan Qian 
Published: March 2024

Abstract

Background
Absent in melanoma 2 (AIM2) is an important developmental regulator for innate immune responses, and recent studies on AIM2 have reported its vital role in cancer development and progression. However, AIM2 in skin cutaneous melanoma (SKCM) tumor immune microenvironment has not been extensively studied.
Methods
We explored the expression and prognostic value of AIM2 at the pan-cancer level based on multiple public databases. We analyzed the SKCM transcriptome sequencing data and clinical information, available on various public databases, using differential analysis, prognostic analysis, machine learning, and various immune infiltration algorithms. We used online visualization databases to explore AIM2 expression in SKCM to determine its prognostic impact. Furthermore, we constructed a risk signature based on AIM2-related genes.
Results
Based on the pan-cancer analysis, AIM2 was found to be an independent prognostic factor for SKCM. AIM2 expression notably differed in SKCM and was associated with an improved survival rate among patients. Increased AIM2 expression promoted the immune response of patients with SKCM, inducing pyroptosis, apoptosis, and necroptosis. In vitro transwell assay and scratch test showed that the knockdown of AIM2 expression increased its invasiveness and metastasis of the SKCM cell line, A875. Knockdown of AIM2 expression revealed decreased expression of ZBP1 and MEFV, the important genes in the PANoptosis complex. Simultaneously, the expression of pyroptosis, apoptosis, and CD8+ T cell marker genes (GSDMD, CASP-8, and CD8A) also decreased. The infiltration levels of various antitumor immune cells positively correlated with AIM2 expression, and the infiltration levels notably differed between patients with high and low levels of AIM2 expression. The Tumor Immune Dysfunction and Exclusion framework analysis revealed that AIM2 expression accurately facilitated the prediction of the efficacy of SKCM immunotherapy. Mechanistic analysis revealed an association between AIM2 overexpression and PANoptosis signaling upregulation, thereby affecting the patterns of chemokines and cytokines in TIME. Furthermore, the prediction and prediction performance of the prognostic model was found to be accurate.
Conclusion
AIM2 is associated with an increased abundance of effector CD8+ T cells, positive responses to immune checkpoint blockade treatment, and improved SKCM prognoses. Therefore, it could be used as a putative enhancer and prognostic biomarker for SKCM treatment.
Anti-inflammatory effects of quercetin, rutin, and troxerutin result from the inhibition of NO production and the reduction of COX-2 levels in RAW 264.7 cells treated with LPS
Authors: Lee Gi Baek , Kim Yohan , Lee Kyung Eun , Vinayagam Ramachandran , Singh Mahendra , Kang Sang Gu 
Published: March 2024

Abstract

Flavonols effectively scavenge the reactive nitrogen species (RNS) and reactive oxygen species (ROS) and act as immune-enhancing, anti-inflammatory, anti-diabetic, and anti-carcinogenic agents. Here, we explored the comparative antioxidant and anti-inflammatory properties of plant-originating flavonols, like quercetin, rutin, and troxerutin against acetylsalicylic acid. Quercetin and rutin showed a high ability to remove active ROS, but troxerutin and acetylsalicylic acid exhibited little such function. In RAW 264.7 cells, quercetin, rutin, and troxerutin did not exhibit cellular toxicity at low concentrations. In addition, quercetin, rutin, and troxerutin considerably (p < 0.05) lowered the protein expression of cyclooxygenase 2 (COX-2) as compared to acetylsalicylic acid in cells inflamed with lipopolysaccharides (LPS). Additionally, in inflamed cells, quercetin and rutin significantly down-regulated the nitrogen oxide (NO) level (p < 0.05) at higher concentrations, whereas Troxerutin did not reduce the NO level. In addition, Troxerutin down-regulated the pro-inflammatory protein markers, such as TNF-α, COX-2, NF-κB, and IL-1β better than quercetin, rutin, and acetylsalicylic acid. We observed that troxerutin exhibited a significantly greater anti-inflammatory effect than acetylsalicylic acid did. Acetylsalicylic acid did not significantly down-regulated the expression of COX-2 and TNF-α (p < 0.05) compared to troxerutin. Hence, it can be concluded that the down-regulation of NO levels and the expression of COX-2 and TNF-α proteins could be mechanisms of action for the natural compounds quercetin, rutin, and troxerutin in preventing inflammation.
Microfacies and diagenesis of Setul Formation, Langkawi, Malaysia: Implications for the depositional environment
Authors: Rahman Aqillah Abdul , Teoh Ying Jia , Abir Ismail Ahmad , Mustafa Fatin , Zolkifli Nurul Hayati Hamizah , Halim Nur Balqis , Badlysham Nurul Syafira , Jaya Ramadhansyah Putra , Ulfa Yuniarti 
Published: March 2024

Abstract

The ongoing investigation into the microfacies and diagenesis of the Setul limestone reveals a considerable expanse of the formation that remains relatively unexplored. The comprehension of microfacies and diagenetic processes within sedimentary rocks holds paramount significance in predicting their viability as hydrocarbon reservoirs, decoding the geological history and depositional environment of a given region, reconstructing past climatic conditions, and understanding the fossil record. To meet the stipulated research objectives, which encompass the identification of microfacies and diagenesis within the Setul limestone, and the discourse on the diagenetic mechanisms operative within the limestone from the Gua Cherita outcrop, a multifaceted approach has been undertaken. This encompasses field observations, acid tests, thin section analyses, and X-ray Diffraction (XRD) analyses. The distinguished microfacies within the Setul limestone encompass packstone, wackestone, grainstone, and mudstone. Among the discerned minerals and grain constituents are dolomite, calcite, calcite veins, ooids, micrite, peloids, pellets, and vestiges of biota like ostracods and brachiopods. This variety of microfacies signifies a shallow marine depositional environment characterized by varying energy levels. Simultaneously, the diagenetic processes analysed in this study include dolomitization, cementation as well as compaction or stylolitization. The validity of this assertion is supported by the occurrence of dolomite, cemented grains, micrites, and the obvious presence of stylolitic structures observed in the samples. In essence, the prevailing expectation is that the results of this study will provide important and valuable insights for the geological community, with a specific emphasis on explaining the complex relationship between facies characteristics and the effectiveness of limestone reservoirs. Furthermore, this research is set to offer comprehensive insights into the physical properties of carbonate rocks, thereby establishing a strong basis to support future efforts within the realm of oil and gas exploration. The implications extend across both economic and industrial domains, highlighted by the inherent potential for the practical use of these findings.
Endothelial SHANK3 Controls Tight Junction of Neonatal Blood-Brain Barrier
Authors: Kim Il Hwan , Kim Yong-Eun , Kim Minseong , Kim Sunwhi , Lee Raham , Ujihara Yusuke , Marquez-Wilkins Esther Magdalena , Jiang Yong-hui , Lee Changhoon , Park Changwon 
Published: March 2024

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disability condition arising from the combination of genetic and environmental factors. Despite the blood-brain barrier (BBB) serving as a crucial gatekeeper, conveying environmental influences into the brain parenchyma, the contributions of BBB in ASD pathogenesis remain largely uncharted. Here we report that a novel form of SHANK3, a gene strongly associated with Phelan-McDermid syndrome and ASD2, expresses in the BBB-forming brain endothelial cells (BECs) and regulates tight junctional (TJ) integrity essential for maintaining the BBB’s barrier function. Loss of Shank3 disrupts the TJ of BECs, leading to increased paracellular passage through endothelial linings. Neonates with endothelium-specific SHANK3 knockout exhibit increased BBB permeability, reduced neuronal excitability, and impaired ultra-sonic communications. Surprisingly, while BBB permeability is restored during adult age, the mutant mice continue to display reduced neuronal excitability, impaired sociability, and repetitive responses. Further investigation reveals that the hyperpermeability resulting from TJ disruption is attributed to the β-Catenin imbalance triggered by SHANK3 knockout, which is rescued by normalizing β-Catenin signaling in vitro and in vivo. These findings highlight a previously unknown pathogenic mechanism stemming from the ASD-risk SHANK3, emphasizing the significance of neonatal BECs in the BBB as a potential therapeutic target of ASD