bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association of LPCAT1-rs9728 polymorphism with cord blood IL-10, MIF, and VEGF levels in neonatal respiratory distress syndrome: a case–control study
Authors: Mohany Khalid M. , Sayed Ahmed Abdelrasoul , El-Asheer Osama Mahmoud , Raheem Yaser F. Abdel , Abbas Ahmed Mohamed , Fawzy Ahmed Mohamed , El-Baz Mona Abd El-Hamid Hassan 
Published: April 2024

Abstract
Background
Lysophospholipid acyltransferase (LPCAT) is crucial for surfactant biosynthesis. It is encoded by LPCAT genes. We investigated the LPCAT1-rs9728 genotypes in neonatal respiratory distress syndrome (NRDS) cases and their possible association with the cord arterial serum interleukin-10 (IL-10), macrophage migration inhibitory factor (MIF), and vascular endothelial growth factor (VEGF) levels.

Methods
The study included 160 neonates grouped into G1: 60 healthy neonates and G2: 100 NRDS cases. IL-10, MIF, and VEGF levels were measured by their corresponding kits. The Gene JETTM Whole Blood Genomic DNA Purification Mini Kit was used to extract the DNA from the newborn venous blood. The quantitative real-time polymerase chain reaction was carried out for LPCAT1-rs9728 genotyping.

Results
The IL-10 and MIF levels were significantly higher, while VEGF levels were significantly lower in G2 than in G1. The percentages of LPCAT1-rs9728 AA and LPCAT1-rs9728 AG genotypes were significantly higher in G2 than in G1. The IL-10 and MIF levels were significantly higher, while the VEGF levels, birth weight, and APGAR score at 1 and 5 min were significantly lower in neonates with LPCAT1-rs9728 AA genotype than in neonates with LPCAT1-rs9728 AG and LPCAT1-rs9728 GG genotypes and in neonates with LPCAT1-rs9728 AG genotype than in neonates with LPCAT1-rs9728 GG genotype.

Conclusion
There is an association between the LPCAT1-rs9728 AA genotype and its A allele and the NRDS development and severity. Further research may provide a better understanding of this association to help future management.
Pan-Canadian Survey of Radiation Oncology Professional Involvement in Global Oncology Initiatives in Low- and Middle-Income Countries
Authors: Beckett Matthew , Al Balushi Mustafa , Chan Jessica , Iakovenko Viktor , Roumeliotis Michael , Hanna Tim , Huang Fleur , Barkati Maroie , Rodin Danielle , Bourque Jean-Marc 
Published: April 2024

PURPOSE
Canadian radiation oncology professionals have a strong history of involvement in global oncology initiatives worldwide. This pan-Canadian survey-based study was conducted to determine the current level of engagement of Canadian radiation oncologists (ROs) and medical physicists (MPs) in global oncology initiatives and broaden the development of these activities.

MATERIALS AND METHODS
This was a cross-sectional study. The survey was designed to characterize current levels of engagement of Canadian ROs and MPs in global oncology initiatives. The survey was open from March 2019 to April 2020. It was disseminated to all Canadian Association of Radiation Oncology and Canadian Organization of Medical Physicists members with two subsequent email reminders.

RESULTS
Survey responses were received from 40 (93%) of the 43 Canadian cancer treatment centers that offer radiotherapy. At least one RO responded at 34 centers (79%) and one MP from 34 centers (79%) with some overlap. A response was received from a total of 93 participants, 47 ROs and 46 MPs. Of all survey participants, 58% reported some experience with global oncology. Nineteen percent of the participants surveyed were currently directly involved in short- or long-term projects, more than half of which have opportunity for additional staff involvement. The projects spanned 26 countries in South America, Africa, and Asia. Quality improvement and capacity building accounted for 27% and 20% of initiatives, respectively. The most common area of engagement was in direct treatment care, accounting for 56% of the projects.

CONCLUSION
This study demonstrates the landscape of involvement of Canadian ROs and MPs in global oncology initiatives. The study also highlights areas of opportunity for broadening international participation and collaboration as it relates to global oncology for Canadian radiation oncology professionals.
From “Natural Institution” to Poetic Genre: Literary Testimony and the Issues of Witnessing in Verse
Authors: Dušanić Dunja 
Published: April 2024

Abstract
This article examines the relationship between poetry and testimony in order to outline a viable framework for interpreting testimonial poetry (or “poetry of witness,” in Carolyn Forché’s terms) as a literary genre in its own right. Neglected in favor of other, mimetically oriented modes of witnessing, especially those in narrative fiction and documentary prose, testimonial poetry has not been extensively studied, and when it has, the studies were often based on inadequate notions of testimony that fail to recognize witnessing as a broader social and linguistic practice. Relying on the sociological approach to eyewitness testimony developed by Renaud Dulong (notably in Le témoin oculaire [1998]), this article proposes a new understanding of poetic testimony, based neither on an overly broad notion of witnessing as living through an event or era, nor on a narrow understanding of witnessing as providing a faithful documentary account of a personal experience. Much like its prose counterpart, poetic testimony enacts a quasi-contractual relationship between authors and readers, whereby the former are committed to telling the truth about a directly experienced event of public importance and the latter, in return, are committed to considering seriously their words, approaching them in good faith. This relationship is driven by an underlying ethical imperative whereby the author acts as a moral witness in Avishai Margalit's sense of the term, and the readers assume the role of a moral community sympathetic to their plight. By referencing examples from American, Hungarian, Russian, French, Polish, and South Slavic twentieth-century poetry, the article shows how a “testimonial” reading of a poem, often very strongly favored on intuitive grounds, modifies generic expectations based on traditional poetic genres and explores its interpretative and ethical implications.
Reading and Listening to Lost Children Archive: Audiobooks as Oral History
Authors: Turner Alison 
Published: April 2024

Abstract
Valeria Luiselli's Lost Children Archive (2019) explores how to find “lost children” who are forced to migrate and interrogates relationships among works of literature, archives, and archiving. Taking place contemporaneously with its publication, the novel follows Ma, Pa, and their two children who are stepsiblings on a road trip from New York City to the US Southwest. Along the way, characters take photographs, and, more unusually, record their own voices and the sounds of the environments they pass through. This article extends explorations of how sound works in the novel to how sound works as the novel by comparing the written text with the audiobook version. After situating the novel among discussions of how literature can contribute to archive making, employing Anne Gilliland and Michelle Caswell's notion of “impossible archival imaginaries” and Erica Johnson's notion of the “neo-archive,” the article shows that readers and audiobook listeners ultimately experience a different narrative. This comparison exposes a third layer of information that prompts questions about what can — and can't — be learned from written and oral records on their own. The article concludes proposing that this third layer of information suggests new possibilities for how literature can contribute to understandings of how archives can include the experiences of marginalized communities with more nuance and complexity.
All In
Authors: Young Liam Cole 
Published: April 2024

Abstract
This article situates the recent explosion of online and app-based sports betting within longer histories of datafication and financialization in sports business and culture. The author tracks four histories in which media technologies and financial logics dissolved previously stable sporting events, athletes, and results into aggregations of data and derivatives that could be leveraged and wagered on. Photography established feelings of confidence and objectivity in horse-race results during the nineteenth and early twentieth centuries. Screen and computational technologies since the 1970s have enabled Las Vegas casino sportsbooks to overwhelm bettors with data abundance. Television and web-based play moved poker at the turn of the millennium away from surprise, chance, and reading people toward probability, risk, and reading data. Around the same time, fantasy sports and management-based video games mirrored financial markets in transforming athletes and leagues into derivatives, that is, disaggregated units that could be reassembled in new digital permutations. Each story helps position contemporary online sports betting within a longer historical arc in which gambling and speculation moved to the center of global economy and culture.
The Condemnation of Hate and the Violence of the Status Quo
Authors: Althoff Sebastian 
Published: April 2024

Abstract
This article interrogates the tension between the way that the condemnation of hate performatively establishes and reinforces discursive and affective boundaries for public debates and the embrace of hate by anti-racist, abolitionist, feminist, and queer activists, that is, their claim that hatred is a valid response to the existential violence inflicted by borders or the police. The cases of activists embracing hate indicate that the boundaries set by the condemnation of hate are too limited to appropriately account for the violence of the status quo. The condemnation of hate, rather, appears to veil this violence, that is, as a way to curb the means to critique and overcome the status quo. The article offers a critical engagement with studies on hate that pathologize the hateful subject, juxtaposing these studies with cases of activists affirming their hatred for politicians, straight people, or San Francisco tech workers. It thereby broadens understandings of hate by proposing that hate as a response to harm can be part of anti-racist, abolitionist, feminist, and queer struggles and provide valuable epistemic effects grounded in theory rather than conspiracies. The article consequently challenges the condemnation of hate by contesting that hate is necessarily illegitimate.
Timolol in the treatment of hard-to-heal wounds: a comprehensive review
Authors: Cornwell David , Goldstein Zachary , Chrea Bopha , McLafferty Robert 
Published: April 2024

Objective: The aims of this study were to ascertain the effectiveness and safety of the off-label use of topical timolol as an adjunct treatment for hard-to-heal (chronic) wounds. Furthermore, to review and analyse the existing literature regarding the use of topical timolol on wounds of varying aetiologies. Method: A systematic review of literature in the English language published between May 1961–May 2021 on the application of topical timolol for hard-to-heal wounds in adults was performed. Each research study was evaluated by two reviewers independently. Studies eligible for inclusion in the review were randomised controlled trials (RCTs), clinical trials, observational studies of at least 4 weeks' duration, case series and case studies. Search strategies were performed according to PRISMA guidelines and included MeSH terms and keyword searches. Results: An initial 878 articles were identified from a search of PubMed, Ovid Medline, Embase, Cochrane, and SCOPUS. Of these, 699 were reviewed for eligibility, 19 were read in full-text, and 12 were selected for inclusion in the review. In total, two RCTs and 10 observational studies, including five case studies, were analysed. All studies demonstrated efficacy and safety of topical timolol; however, statistical analysis remained limited by lack of blinding and small sample sizes. Conclusion: This review concludes with all currently available evidence that topical timolol may be considered as an effective and safe adjunct treatment for refractory wounds, primarily venous leg ulcers and diabetic foot ulcers. Given the overall safety, low cost and ease of application of topical timolol, this review provides evidence in favour of off-label use and should prompt further, more rigorous studies.
Hospital-acquired pressure injury: our seven years of experience
Authors: Oztas Pinar , Demirci Emine Karabulut , Aksakal F Nur Baran , Yildiz Mucahit 
Published: April 2024

Objective: A pressure injury (PI) happens on the skin and in deeper tissues. Generally, it occurs due to prolonged compression over bony structures. A PI, when occurring during a hospital stay, is regarded as a hospital-acquired pressure injury (HAPI), and is considered as a marker for patient care quality. It might cause medical, legal or economic problems, and could be a burden on health systems. In this study we evaluate the factors contributing to HAPI formation. Method: Between June 2014–June 2021, we retrospectively investigated the files of patients who were hospitalised with different medical conditions in Bayindir Sögütözü Hospital, Ankara, Turkey, for patients' age, sex, Waterlow scale score, mobilisation status, application of zinc-containing and/or barrier creams (ZnBC), airbed usage, hospitalisation period, and the day of wound opening. Results: The study cohort comprised 2327 hospitalised patients: 303 (13%) developed Stage 2 and deeper PIs; 2024 patients were hospitalised and discharged without wound opening. We found an increased risk in male patients and a lack of efficacy of ZnBC in protection from HAPI in our study population. However, we observed that ZnBC helped to delay wound opening and that the most protective treatment was the use of airbeds. Conclusion: Health professionals should be more aware of HAPI formation with prolonged hospitalisation periods. Only the use of an airbed for a patient hospitalised for a long period appears to be protective against PI formation. On the other hand, use of ZnBC delays wound opening. However, further research is needed to demonstrate the protective effect of ZnBC, due to the lack of randomisation in our study and the lack of some nursing records.
Mild aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL)-type reactions also present in patients with failed knee prostheses
Authors: Rajamäki Anni , Lehtovirta Lari , Niemeläinen Mika , Reito Aleksi , Parkkinen Jyrki , Peräniemi Sirpa , Vepsäläinen Jouko , Eskelinen Antti 
Published: April 2024

AimsMetal particles detached from metal-on-metal hip prostheses (MoM-THA) have been shown to cause inflammation and destruction of tissues. To further explore this, we investigated the histopathology (aseptic lymphocyte-dominated vasculitis-associated lesions (ALVAL) score) and metal concentrations of the periprosthetic tissues obtained from patients who underwent revision knee arthroplasty. We also aimed to investigate whether accumulated metal debris was associated with ALVAL-type reactions in the synovium.MethodsPeriprosthetic metal concentrations in the synovia and histopathological samples were analyzed from 230 patients from our institution from October 2016 to December 2019. An ordinal regression model was calculated to investigate the effect of the accumulated metals on the histopathological reaction of the synovia.ResultsMedian metal concentrations were as follows: cobalt: 0.69 μg/g (interquartile range (IQR) 0.10 to 6.10); chromium: 1.1 μg/g (IQR 0.27 to 4.10); and titanium: 1.6 μg/g (IQR 0.90 to 4.07). Moderate ALVAL scores were found in 30% (n = 39) of the revised knees. There were ten patients with an ALVAL score of 6 or more who were revised for suspected periprosthetic joint infection (PJI), aseptic loosening, or osteolysis. R2 varied between 0.269 and 0.369 for the ordinal regression models. The most important variables were model type, indication for revision, and cobalt and chromium in the ordinal regression models.ConclusionWe found that metal particles released from the knee prosthesis can accumulate in the periprosthetic tissues. Several patients revised for suspected culture-negative PJI had features of an ALVAL reaction, which is a novel finding. Therefore, ALVAL-type reactions can also be found around knee prostheses, but they are mostly mild and less common than those found around metal-on-metal prostheses.Cite this article: Bone Joint Res 2024;13(4):149–156.
Selection, engineering, and in vivo testing of a human leukocyte antigen–independent T-cell receptor recognizing human mesothelin
Authors: Hiscox Martyn J. , Wasmuth Alexandra , Williams Chris L. , Foot Jaelle N. , Wiedermann Guy E. , Fadda Valeria , Boiani Sara , Cornforth Terri V. , Wikiert Karolina A. , Bruton Shaun , Cartwright Neil , Anderson Victoria Elizabeth , Barnes Christopher S. , Vieira Joao V. , Birch-Machin Ian , Gerry Andrew B. , Miller Karen , Pumphrey Nicholas J. 
Published: April 2024

Background
Canonical α/β T-cell receptors (TCRs) bind to human leukocyte antigen (HLA) displaying antigenic peptides to elicit T cell−mediated cytotoxicity. TCR-engineered T-cell immunotherapies targeting cancer-specific peptide-HLA complexes (pHLA) are generating exciting clinical responses, but owing to HLA restriction they are only able to target a subset of antigen-positive patients. More recently, evidence has been published indicating that naturally occurring α/β TCRs can target cell surface proteins other than pHLA, which would address the challenges of HLA restriction. In this proof-of-concept study, we sought to identify and engineer so-called HLA-independent TCRs (HiTs) against the tumor-associated antigen mesothelin.

Methods
Using phage display, we identified a HiT that bound well to mesothelin, which when expressed in primary T cells, caused activation and cytotoxicity. We subsequently engineered this HiT to modulate the T-cell response to varying levels of mesothelin on the cell surface.

Results
The isolated HiT shows cytotoxic activity and demonstrates killing of both mesothelin-expressing cell lines and patient-derived xenograft models. Additionally, we demonstrated that HiT-transduced T cells do not require CD4 or CD8 co-receptors and, unlike a TCR fusion construct, are not inhibited by soluble mesothelin. Finally, we showed that HiT-transduced T cells are highly efficacious in vivo, completely eradicating xenografted human solid tumors.

Conclusion
HiTs can be isolated from fully human TCR–displaying phage libraries against cell surface-expressed antigens. HiTs are able to fully activate primary T cells both in vivo and in vitro. HiTs may enable the efficacy seen with pHLA-targeting TCRs in solid tumors to be translated to cell surface antigens.
The role of advanced practice nurses in improving healthcare outcomes for patients with chronic kidney disease: A scoping review protocol
Authors: Nozu Hanako , Tamura Haruka , Kudo Takemi , Araki Tomoko , Sato Hidetaka , Watanabe Takao , Sasagawa Isoji 
Published: April 2024

Introduction
The number of patients with chronic kidney disease is increasing worldwide; previous studies have suggested that advanced practice nurses, including nurse practitioners and clinical nurse specialists, with expert practice skills can provide high-quality care and solve complex healthcare problems. In general, nurse practitioners are generalist nurses who work as autonomous clinicians with whole personal care. Clinical nurse specialists, in contrast, are nurses with advanced nursing knowledge and skills for individuals or specific populations. Their roles are independent and different; however, similarities exist in their role in potentially improving healthcare outcomes. Although two previous studies described the role of nephrology nurse practitioners, they were systematic reviews, and their outcomes were limited. To clarify the overall aspect of advanced practice nurses’ role, it is necessary to extract the studies illustrating advanced practice nurses’ practices for patients with chronic kidney disease.

Objective
This study aims to map the literature describing the role of advanced practice nurses in improving healthcare outcomes for patients with chronic kidney disease.

Materials and methods
This scoping review will be conducted using the Joanna Briggs Institute methodology for scoping review. Online databases will be searched across MEDLINE (PubMed), CINAHL (EBSCOhost), Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and Web of Science. Only studies published in English will be included, and no date limit will be set. Chronic kidney disease, renal replacement therapy, and advanced practice nurses as keywords and related search terms will be used. Two independent reviewers will screen the title and abstract/full-text; in case of discrepancy, a third reviewer will make the final decision. The results will be extracted and presented following the review question concerning the study characteristics, patients’ characteristics, condition of chronic kidney disease, and role of advanced practice nurses.
Incentives of the Mind: Kant and Baumgarten on the Impelling Causes of Desire
Authors: Walschots Michael 
Published: April 2024

Abstract
In this paper I propose to shed new light on the role of feeling in Kant’s psychology of moral motivation by focusing on his concept of an incentive (Triebfeder), which he borrowed from one of his most important rationalist predecessors, Alexander Gottlieb Baumgarten. I argue that, similar to Baumgarten, Kant understands an incentive to refer to the ground of desire, and that feelings function as a specific kind of ground within Kant’s psychology of moral action, namely as the ‘impelling cause’ of desire. I claim that this interpretation has several advantages over the alternatives currently on offer in the literature.
Classification and logging identification of reservoir space near the upper Ordovician pinch-out line in Tahe Oilfield
Authors: Yang Debin , Jin Yanlin , Zhang Juan , Xie Runcheng , Chen Huaxin , Yin Shuai , Cai Wenli 
Published: April 2024

Abstract
Real drilling near the upper Ordovician pinch-out line in the Tahe Oilfield shows that the drilling encountered karst reservoir. However, due to the transitional position between the denudation area and the overlying area and the special karst geological background, the existing drilling and completion data show that the reservoir space types in this area are complex and diverse. In this article, the classification of reservoir space near the Upper Ordovician pinch-out line and the extraction of logging response characteristics have been carried out based on drilling, logging, core, and crude oil quality data. Through this study, the classification scheme of karst reservoir space in the study area is proposed. The reservoir space types of karst reservoirs include fracture–cave, fracture–pore (light and low resistivity), fracture–pore (heavy and high resistivity), dissolved pore–pore (light and low resistivity), dissolved pore–pore (heavy and high resistivity), isolated pore (relatively isolated distribution of pores and fractures, weakly connected), and cave-type reservoir (sand and gravel filled or semi-unfilled). Furthermore, conventional logging parameters and five parameters sensitive to reservoir properties are extracted. The intersection maps based on the combination forms, fluid properties, and reservoir space effectiveness of different types of reservoir spaces are effective in distinguishing seven types of reservoir spaces and two types of stratified karst reservoirs. In this study, the reservoir space types and logging response characteristics of reservoirs near the Upper Ordovician pinch-out line are defined, which can provide a reliable geological basis for the quantitative identification and distribution evaluation of karst reservoirs.