bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the 2021 AASLD Practice Guidance for Albumin Infusion in Elective Therapeutic Paracentesis: A Regression Discontinuity Design
Authors: Tanaka Tomohiro , Vander Weg Mark , Jones Michael P. , Wehby George 
Published: March 2024

INTRODUCTION:
The 2021 American Association for the Study of Liver Disease (AASLD) Practice Guidance recommends albumin infusion when removing ≥5 L of ascites to prevent post-paracentesis circulatory dysfunction. However, the optimal criteria and scenarios for initiating albumin infusion subsequent to therapeutic paracentesis (TP) have been subject to limited scientific inquiry.

METHODS:
We conducted a retrospective cohort study at a US academic healthcare center. Participants received elective, outpatient TP between July 2019 and December 2022. Patients with spontaneous bacterial peritonitis, post-TP clinical adjustments, and/or hospitalization were excluded. The institution strictly followed the AASLD Guidance. We used a sharp regression discontinuity (RD) design to estimate the effect of albumin infusion at the AASLD Guidance-recommended cutoff of 5 L on serum creatinine and sodium trajectory after TP.

RESULTS:
Over the study period, 1,457 elective TPs were performed on 235 unique patients. Albumin infusion at the threshold of 5 L of ascites removal reduced serum creatinine levels by 0.046 mg/dL/d (95% confidence interval 0.003–0.116, P = 0.037) and increased serum sodium levels by 0.35 mEq/L/d (95% confidence interval 0.15–0.55, P = 0.001) compared with those who did not receive albumin infusion. The RD plots indicated worsened serum creatine/sodium levels after draining 3 L of fluid, approaching levels similar to or worse than with albumin infusion at 5 L or more.

DISCUSSION:
Our RD models supported the 2021 AASLD Guidance with robust estimation of causal effect sizes at the cutoff level of 5 L. Nevertheless, the findings also highlight the need to further evaluate the efficacy of albumin infusion in patients who undergo elective TP and have 3–5 L of ascites removed.
Current vision on mechanism of action of bisphosphonates. The effect of long-term administration of bisphosphonates on bone tissue (preclinical studies)
Authors: Toroptsova N. V. , Baranova I. A. 
Published: March 2024

Osteoporosis (OP) is one of the common chronic diseases in the elderly, which requires long–term therapy. Bisphosphonates (BP) belong to the first-line choice medications for the treatment of OP, however, prolonged period of bisphosphonates use has been associated with increased risk of atypical femoral fractures (AFFs), medication-related osteonecrosis of the jaw (MRONJ) and the impact on fracture healing, which attracts increased attention to the current widespread use of them.The article presents the existing classes of BP according to their chemical structure and mechanism of action, differences in their antiresorptive potencies. The data of studies on animal models on the effect of BP on the mechanical properties of bone, fracture repair, as well as the development of MRONJ are presented.
The CoLab score is associated with SARS-CoV-2 viral load during admission in individuals admitted to the intensive care unit: the CoLaIC cohort study
Authors: Schoenmakers Tom , Leers Mathie P.G. , Deneer Ruben , van Rosmalen Frank , Gorissen Stefan H.M. , Verboeket-van de Venne Wilhelmine P.H.G. , Vojinovic Una , van Mook Walther N.K.A. , Wolffs Petra F.G. , van Bussel Bas C.T. , van Loo Inge H.M. 
Published: March 2024

Abstract

Objectives
The present study examines the temporal association between the changes in SARS-CoV-2 viral load during infection and whether the CoLab-score can facilitate de-isolation.

Methods
Nasal swabs and blood samples were collected from ICU-admitted SARS-CoV-2 positive patients at Maastricht UMC+ from March 25, 2020 to October 1, 2021. The CoLab-score was calculated based on 10 blood parameters and age and can range from −43 to 6. Three mixed effects analyses compared patient categories based on initial PCR Ct values (low; Ct≤20, mid; 20>Ct≤30, high; Ct>30), serial PCR Ct values to CoLab-scores over time, and the association between within-patient delta Ct values and CoLab-scores.

Results
In 324 patients, the median Ct was 33, and the median CoLab-score was −1.78. Mid (n=110) and low (n=41) Ct-categories had higher CoLab-scores over time (+0.60 points, 95 % CI; 0.04–1.17, and +0.28 points, 95 % CI −0.49 to 1.04) compared to the high Ct (n=87) category. Over time, higher serial Ct values were associated with lower serial CoLab-scores, decreasing by −0.07 points (95 % CI; −0.11 to −0.02) per day. Increasing delta Ct values were associated with a decreasing delta CoLab-score of −0.12 (95 % CI; −0.23; −0.01).

Conclusions
The study found an association between lower viral load on admission and reduced CoLab-score. Additionally, a decrease in viral load over time was associated with a decrease in CoLab-score. Therefore, the CoLab-score may make patient de-isolation an option based on the CoLab-score.
Recent advancements in multinuclear early transition metal catalysts for olefin polymerization through cooperative effects
Authors: Yue Qiang , Gao Rong , Song Zhihui , Lai Jingjing , Zhang Randi , Wang Ying , Gou Qingqiang 
Published: March 2024

Abstract
The pursuit of high-performance polyolefin materials has been an objective for chemists. Recently, the development of multinuclear catalysts has significantly enabled the preparation of high-performance polyolefin materials. In this review, we mainly focus on the cooperative effects of multinuclear early transition metal catalysts and provide a comprehensive summary of the research progress in binuclear and multinuclear early transition metal catalysts over the past decade. Compared with the catalytic performance and polymer structure of these catalysts with mononuclear catalysts, we have found that various factors, such as steric hindrance effect, electronic effect, heteroatom effect, hydrogen bonding interaction, the distance between metal centers in multinuclear metal catalysts, and the use of additives, have distinctive and significant impacts on catalyst performance. These effects give rise to notable cooperative effects. This review offers crucial insights and serves as a valuable reference for shaping the future development directions of binuclear and multinuclear early transition metal catalysts.
Performance assessment, through numerical simulation and experimental evaluation, of a thin-film ultraviolet reactor for the processing of fruit juices
Authors: Solari Federico , Lysova Natalya , Martelli Francesco , Volpi Andrea , Bottari Benedetta , Montanari Roberto 
Published: March 2024

Abstract
The paper presents a numerical approach to investigate the performance of a thin-film ultraviolet reactor in treating three different fruit juices (apple, orange and pineapple) with UV-C radiation, under six flow rate conditions. Minimum, average and maximum doses were calculated for each configuration, by integrating, over time the irradiance over one thousand different streamlines. The presented approach allows for calculating the dose distribution achieved, thus assessing both the fulfilment of regulatory requirements and the uniformity of the treatment. Experimental tests were finally performed on both apple and orange juice, with a flow rate of 80 L/h. For apple juice, more than 3 Log CFU/mL reductions were obtained on Escherichia coli ATCC 11,229, while, for orange juice, a negligible reduction (0.05 Log CFU/mL) was achieved. These results, according to biodosimetry data from other studies, correspond to UV-C dose distributions that confirm those calculated.
Determination of 10B/11B in boric acid and B4C using LA-ICPMS
Authors: Ujjwal Kumar Maity , Janarthanam Namitha , Pulipaka Bavya , Kumar Ushalakshmi , Periasamy Manoravi , Sreenivasan Vijayalakshmi 
Published: March 2024

Abstract
Boron isotopic ratio measurement is very important in the nuclear industry because it is used as neutron poison (in the form of boric acid or a B4C pellet) and control rod material (B4C pellet) in nuclear power plants. Since 10B has a higher neutron absorption cross-section, enriched 10B is used in the nuclear industry and the extent of enrichment varies from 50–90 %. Therefore, it is essential to determine the 10B/11B ratio in boric acid and B4C. The prime purpose of the present study is to utilize LA-ICPMS for evaluating 10B/11B ratio both in solution (boric acid) and solid (B4C pellet) without any pre-treatment so that the difficulty in dissolution or powdering process of B4C (one of the hardest materials) can be avoided and the B4C pellet can be reused. The results obtained from LA-ICPMS for the B4C pellet are discussed and compared with the solution ICPMS, TIMS, and LIMS. The solutions of boric acid (natural abundance) and dissolved B4C (natural & ∼67 % enriched isotopic composition) were analyzed by LA-ICPMS and validated by liquid sampling ICPMS data.
Monosynaptic rabies tracing reveals sex- and age-dependent dorsal subiculum connectivity alterations in an Alzheimer's disease mouse model
Authors: Ye Qiao , Gast Gocylen , Wilfley Erik George , Huynh Hanh , Hays Chelsea , Holmes Todd C. , Xu Xiangmin 
Published: March 2024

The subiculum (SUB), a hippocampal formation structure, is among the earliest brain regions impacted in Alzheimer's disease (AD). Towards a better understanding of AD circuit-based mechanisms, we mapped synaptic circuit inputs to dorsal SUB using monosynaptic rabies tracing in the 5xFAD mouse model by quantitatively comparing the circuit connectivity of SUB excitatory neurons in age-matched controls and 5xFAD mice at different ages for both sexes. Input-mapped brain regions include hippocampal subregions (CA1, CA2, CA3), medial septum and diagonal band (MS-DB), retrosplenial cortex (RSC), SUB, post subiculum (postSUB), visual cortex (Vis), auditory cortex (Aud), somatosensory cortex (SS), entorhinal cortex (EC), thalamus, perirhinal cortex (Prh), ectorhinal cortex (Ect) and temporal association cortex (TeA). We find sex- and age-dependent changes in connectivity strengths and patterns of SUB presynaptic inputs from hippocampal subregions and other brain regions in 5xFAD mice compared to control mice. Significant sex differences for SUB inputs are found in 5xFAD mice for CA1, CA2, CA3, postSUB, Prh, LEC, and MEC: all areas critical for learning and memory. Notably, we find significant changes at different ages for visual cortical inputs to SUB. While visual function is not ordinarily considered defective in AD, these specific connectivity changes reflect altered visual circuitry contributing to learning and memory deficits. Our work provides new insights into SUB-directed neural circuit mechanisms during AD progression and supports the idea that neural circuit disruptions are a prominent feature of AD.Significance StatementAlzheimer's disease is a major health concern in the elderly, but the underlying neural circuit mechanisms of this disease remain unclear. The SUB is a critical brain region for relaying and integrating hippocampal and cortical information. In this study, we applied monosynaptic rabies viral tracing to study the circuit connectivity changes of SUB excitatory neurons in age-matched, gender-balanced control and 5xFAD mice. We identified age-progressive alterations of connectivity strengths and patterns of SUB neurons in AD model mice. The circuit alterations are differentially impacted in different genders for specific brain regions. Our new findings are supported by human AD literature and can help to identify potential new therapeutical circuit targets for AD treatments.
The conditions for workplace learning implementation in Laotian higher education
Authors: Vannasy Vanmany , Sengsouliya Souksakhone 
Published: March 2024

AbstractWorkplace learning is a necessity for the organizational growth of all types of organizations, including higher education institutions. There are different directions proposed on how to make the implementation of workplace learning realistic, however, the best practices in one context may not apply well in another. This paper investigated the conditions required for the implementation of workplace learning in the case study of Laotian higher education. Firstly, 12 faculty members were invited to a semi-structured interview. The study employed a deductive category assignment of QCA in analyzing the data. The findings revealed that three conditions, namely, individual-related, organizational-related, and environmental-related conditions, appear to be key and are taken into account in developing favorable workplace learning. A further quantitative study in this area is strongly recommended.
Polenta or Mamaliga? British Perceptions of a South-east European Dish
Authors: Jianu Angela 
Published: March 2024

This article focuses on the historical importance of cornmeal preparations in Romania, especially among the poor during the 18th and 19th- centuries, and the consequences of over-reliance on this food which, when not properly prepared, leads to the potentially fatal disease of Pellagra, caused by a lack of the vitamin niacin (vitamin B3).
Chemoreactomic analysis of acyzole in comparison with zinc derivatives of nonsteroidal anti-inflammatory drugs
Authors: Galenko-Yaroshevsky P. A. , Torshin I. Yu. , Gromov A. N. , Gromova O. A. , Murashko R. A. , Zelenskaya A. V. , Alukhanyan L. O. , Shelemekh O. V. 
Published: March 2024

Background. Nonsteroidal anti-inflammatory drugs (NSAIDs) are characterized by ulcerogenic effects and used for effective and safe pharmacotherapy of inflammation and pain. The zinc-containing drug acyzole is a promising anti-inflammatory drug that potentially does not have this drawback. Objective: to conduct chemoreactomic modeling of the pharmacological effects of acyzole and zinc derivatives of well-known NSAIDs (diclofenac, nimesulide, ketorolac).Material and methods. The analysis of the pharmacological capabilities of NSAIDs was based on a chemoinformatic approach, i.e. comparing the chemical structure of the studied molecules with the structures of millions of other molecules with established molecular pharmacological properties. The analysis procedure was based on the latest machine learning technologies developed in the theory of topological and metric analysis of feature descriptions.Results. It was shown that acyzole might have an anti-inflammatory effect due to its impact on the activity of cytokines and, partly, on the metabolism of prostaglandins and leuktrienes. The central effects of acyzole are comparable to those of zinc-NSAIDs. The analgesic effect of acyzole may be associated with kinin receptors inhibition, and weak antihistamine and antinociceptin effects. Acizol may also exhibit a gastroprotective effect. It was established that acyzole, to a lesser extent than the reference molecules, negatively affected the metabolism of vitamins and microelements.Conclusion. Chemoreactomic profiling of acyzole indicates prospects for its use as an anti-inflammatory drug.
Evaluation of the Components Released by Wine Yeast Strains on Protein Haze Formation in White Wine
Authors: Giese Ellen Cristine , Ocaña Maria Chacón , Simancas Nuria Barrajón , Pérez Ana I. Briones , Dekker Robert F. H. , Barbosa Aneli M. 
Published: March 2024

Cultures of 23 indigenous yeast strains (22 Saccharomyces cerevisiae and a non-Saccharomyces, Torulaspora delbrueckii), isolated from fermentation tanks at wineries in Castilla-La Mancha (Spain), and were performed under winemaking conditions using a synthetic must. Polysaccharide analysis and turbidity assays were conducted so as to observe the capacity of the released mannoproteins against protein haze formation in white wine, and 3 strains (2 Saccharomyces cerevisiae and T. delbrueckii) were chosen for further experiments. The action of a commercial b-glucanolytic enzyme preparation (Lallzyme BETA®), and a β-(1→3)-glucanase preparation from Trichoderma harzianum Rifai were evaluated to release polysaccharides from the different yeast strains’ cell walls. Protection against protein haze formation was strain dependent, and only two strains (Sc2 and Sc4) presented >50% stabilization in comparison to controls. Addition of β-glucanases did not increase the concentrations of polysaccharides in the fermentation musts; however, a significant increase of polymeric mannose (mannoproteins) was detected using an enzymatic assay following total acid hydrolysis of the soluble polysaccharides. Enzymatic treatment presented positive effects and decreased protein haze formation in white wine.
DOI http://dx.doi.org/10.17807/orbital.v8i6.869
Self-Efficacy, Independensi, Kompleksitas Tugas dan Perannya pada Audit Judgement
Authors: Prayudatama Happy Bayu 
Published: March 2024

Tujuan penelitian ini secara umum adalah untuk mendapatkan bukti empiris dan menganalisis pengaruh self-efficacy dan indepedensi yang berpengaruh terhadap audit judgment yang dimoderasi oleh kompleksitas tugas. Auditor BPKP Perwakilan Provinsi Jawa Timur menjadi responden dalam memperoleh data primer penelitian. Pengukuran atas jawaban pertanyaan kuesioner menggunakan skala likert 1-7 dengan model Partial Least Square (PLS)-Structural Equation Modelling (SEM) serta penggunaan aplikasi SmartPLS. Hasil penelitian berdasarkan 76 auditor menunjukkan bahwa Self-Efficacy dan Independensi berpengaruh positif signifikan terhadap audit judgment. Variabel moderasi berupa kompleksitas tugas menunjukkan bahwa tidak dapat memoderasi pengaruh self-efficacy dan independensi terhadap audit judgment. Hasil penelitian ini diharapkan memberikan masukan kepada pada pemegang kepentingan untuk memutuskan kebijakan terutama untuk bidang pengawasan/audit.
Oblicza Siedmiogrodu Kazimiery Iłłakowiczówny albo topografia kontradykcyjna
Authors: Niewiadomski Andrzej 
Published: March 2024

W twórczości Kazimiery Iłłakowiczówny, inspirowanej w dużej mierze licznymi podróżami i przemieszczeniami, istotną rolę odgrywa wyobraźnia topograficzna i eksponowanie różnego rodzaju związków z konkretnymi miejscami. Ośmioletni pobyt poetki w Siedmiogrodzie w latach wojny i utwory związane z tą krainą dobrze ilustrują specyficzny sposób postrzegania przestrzeni, co dotyczy także pozostałej części twórczości Iłłakowiczówny. Miejsce widziane jest tu jako rzeczywistość sprzeczności: pomiędzy obcością wygnania i tęsknotą do kraju rodzinnego, pomiędzy ignorowaniem nowej rzeczywistości a próbami zakorzenienia, pomiędzy węgierskimi i rumuńskimi elementami kultury Siedmiogrodu, pomiędzy jego peryferyjnością w obrębie kultury węgierskiej i centralną pozycją Budapesztu, pomiędzy Północą i Południem. Sprzeczności te rządzą postrzeganiem miejsc, porządkują miejsce i przestrzeń i pozwalają mówić o pięciu koniecznych elementach tworzących obraz topografii kontradykcyjnej obecnej w tej twórczości. Topografia ta jest formą mediacji w procesie poznawania świata, a jednocześnie przeciwstawiona została przez poetkę metafizycznemu wymiarowi doświadczenia.
Estimating The Exploration And Production (E&P) Industry's Rig Contract Business Owner
Authors: Radjagoekgoek Robert Pangihutan , Awwal Muhammad Shafiu  
Published: March 2024

According to Article 33 of the 1945 Structure, oil and gas have the potential to greatly influence state and revenue generation sources, thereby realizing societal welfare and economic prosperity. For this reason, oil and gas have a crucial and strategic position among natural resources. As a result, a specialized work group for exploration and production (E&P) was established through the enactment of Oil and Gas Law Number 22, 2001. This organization is in charge of supervising all exploration and production-related operations. In accordance with Presidential Regulation No. 12, 2021, Procedural Instruction 007, 2017, exploration and production builders carry out the rig procurement procedure to rig providers builders with their proposal Owner Estimate's worth. There are conflicting interpretations and discrepancies in the Owner Estimate instruction problem for upstream exploration and production (E&P). Concerns pertaining to areas of law positivism that Owner Estimate provides may or may not be secret in the process. It allows for collusion during the purchasing procedure. Normative juridical analysis is used in the research to make Owner Estimates of Value and to cover regulation. Therefore, in order to achieve conformity with the agreement principle and legal certainty, it is required to alter the President's Regulation and the Summary of Procedural Instruction. In order for the specialized work group for exploration and production (E&P), the E&P builders, and the rig providers to execute upstream business flawlessly and optimally to support communal welfare, the regulation's evaluation will support legal clarity, ability, and persuasiveness.
Manajemen Usaha Budidaya Ikan Papuyu: Pengolahan Pakan Mandiri Untuk Menekan Biaya Produksi
Authors: Sofia Leila Ariyani , Zain Muhammad Adnan , Baturante Elmiwia Rani 
Published: March 2024

Pengabdian Kepada Masyarakat ini bertujuan untuk memberikan pembaruan pengetahuan dan keterampilan pengolahan pakan ikan secara mandiri bagi kelompok pembudidaya ikan papuyu. Metode yang diterapkan terdiri dari penyuluhan, pelatihan, dan evaluasi. Pelaksanaan pengabdian telah memberikan perubahan Penyuluhan dan pelatihan yang diberikan kepada kelompok mitra (Pokdakan Papuyu Sakti Banjar) telah menimbulkan perubahan pengetahuan dan sikap peserta suluh dari yang tidak tahu (26,11%) menjadi tahu (71,11%) mengenai pengolahan pakan ikan mandiri. Peserta suluh rata-rata mampu mengolah pakan ikan dengan baik. Pengolahan pakan ikan mandiri yang diajarkan diharapkan dapat meningkatkan kemampuan produksi serta profitabilitas usaha yang dijalankan pokdakan di Desa Karang Intan Kabupaten Banjar.
Pelatihan Pengelolaan Sampah Berbasis 3r Sebagai Upaya Mitigasi Banjir Pada Masyarakat Di Kampung Sasirangan Kelurahan Seberang Masjid Kota Banjarmasin
Authors: Heriyani Farida , Skripsiana Nika Sterina , Nursantari Widya 
Published: March 2024

Kampung Sasirangan Kelurahan Seberang Mesjid berada di wilayah Kota Banjarmasin. Letak wilayahnya yang berada di bantaran Sungai rentan banjir dengan penduduk yang padat menyebabkan banyak sampah yang dihasilkan, dibuang sembarangan di sekitar rumah, selokan dan sungai, sehingga dapat menyebabkan banjir di daerah tersebut. Tujuan kegiatan ini untuk menambah pengetahuan dengan pelatihan kepada masyarakat untuk pengelolaan sampah sebagai salah satu upaya mitigasi banjir. Metode kegiatan ini berupa pelatihan kepada masyarakat, terdiri dari pemberian edukasi dengan metode ceramah dan diskusi serta pelatihan pengelolaan sampah berbasis 3R (reduce, reuse, dan recycle). Target dari kegiatan ini adalah terdapat pengurangan jumlah sampah yang dibuang ke TPS dan tidak ada yang dibuang ke sungai atau selokan sehingga dapat mencegah terjadinya banjir. Evaluasi jangka pendek dilakukan melalui pemberian pretest dan post-test pengetahuan peserta. Hasil kegiatan didapatkan nilai rerata pretest sebesar 5,93, posttest sebesar 9,00 dan uji Wilcoxon nilai p 0,000. Kesimpulan yang didapat adalah terdapatnya peningkatan pengetahuan dan keterampilan peserta tentang pengelolaan sampah tepat guna dan mampu mendaur ulang sampah sebagai upaya mitigasi banjir.