bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface Modification of Nerve Guide Conduits with ECM Coatings and Investigating Their Impact on Schwann Cell Response
Authors: Pinzon‐Herrera Luis , Magness John , Apodaca‐Reyes Hector , Sanchez Jesus , Almodovar Jorge 
Published: February 2024

AbstractIn this study, layer‐by‐layer coatings composed of heparin and collagen are proposed as an extracellular mimetic environment on nerve guide conduits (NGC) to modulate the behavior of Schwann cells (hSCs). The authors evaluated the stability, degradation over time, and bioactivity of six bilayers of heparin/collagen layer‐by‐layer coatings, denoted as (HEP/COL)6. The stability study reveals that (HEP/COL)6 is stable after incubating the coatings in cell media for up to 21 days. The impact of (HEP/COL)6 on hSCs viability, protein expression, and migration is evaluated. These assays show that hSCs cultured in (HEP/COL)6 have enhanced protein expression and migration. This condition increases the expression of neurotrophic and immunomodulatory factors up to 1.5‐fold compared to controls, and hSCs migrated 1.34 times faster than in the uncoated surfaces. Finally, (HEP/COL)6 is also applied to a commercial collagen‐based NGC, NeuraGen, and hSC viability and adhesion are studied after 6 days of culture. The morphology of NeuraGen is not altered by the presence of (HEP/COL)6 and a nearly 170% increase of the cell viability is observed in the condition where NeuraGen is used with (HEP/COL)6. Additionally, cell adhesion on the coated samples is successfully demonstrated. This work demonstrates the reparative enhancing potential of extracellular mimetic coatings.
Synergistic Brilliance: Engineered Bacteria and Nanomedicine Unite in Cancer Therapy
Authors: Zhou Yaofeng , Li Qianying , Wu Yuhao , Zhang Wan , Ding Lu , Ji Chenlin , Li Ping , Chen Tingtao , Feng Lili , Tang Ben Zhong , Huang Xiaolin 
Published: February 2024

AbstractEngineered bacteria are widely used in cancer treatment because live facultative/obligate anaerobes can selectively proliferate at tumor sites and reach hypoxic regions, thereby causing nutritional competition, enhancing immune responses, and producing anticancer microbial agents in situ to suppress tumor growth. Despite the unique advantages of bacteria‐based cancer biotherapy, the insufficient treatment efficiency limits its application in the complete ablation of malignant tumors. The combination of nanomedicine and engineered bacteria has attracted increasing attention owing to their striking synergistic effects in cancer treatment. Engineered bacteria that function as natural vehicles can effectively deliver nanomedicines to tumor sites. Moreover, bacteria provide an opportunity to enhance nanomedicines by modulating the TME and producing substrates to support nanomedicine‐mediated anticancer reactions. Nanomedicine exhibits excellent optical, magnetic, acoustic, and catalytic properties, and plays an important role in promoting bacteria‐mediated biotherapies. The synergistic anticancer effects of engineered bacteria and nanomedicines in cancer therapy are comprehensively summarized in this review. Attention is paid not only to the fabrication of nanobiohybrid composites, but also to the interpromotion mechanism between engineered bacteria and nanomedicine in cancer therapy. Additionally, recent advances in engineered bacteria‐synergized multimodal cancer therapies are highlighted.
High‐Index and Low‐Loss Topological Insulators for Mid‐Infrared Nanophotonics: Bismuth and Antimony Chalcogenides
Authors: Menabde Sergey G. , Heiden Jacob T. , Zenin Vladimir A. , Mortensen N. Asger , Jang Min Seok 
Published: February 2024

AbstractTopological insulators generally have dielectric bulk and conductive surface states. Consequently, some of these materials are shown to support polaritonic modes at visible and THz frequencies. At the same time, the optical properties of topological insulators in the mid‐infrared (mid‐IR) remain poorly investigated. Here, near‐field imaging is employed to probe the mid‐IR response from the exfoliated flakes of bismuth (Bi)/selenide (Se)/telluride (Te)/antimony (Sb) crystals with varying stoichiometry – Bi2Se3, Bi2Te2Se, and Bi1.5Sb0.5Te1.7Se1.3 – in pristine form as well as covered by thin flakes of hexagonal boron nitride (hBN) is employed. Contrary to theoretical expectations, all three materials exhibit a dielectric response with a high refractive index and with a loss below the experimental detection limit. Particularly, the near‐field mapping of propagating phonon‐polaritons in hBN demonstrates that all three van der Waals crystals with different stoichiometry act as a practically lossless dielectric substrate with an ultra‐high refractive index of up to 7.5 in Bi2Te2Se. Such a unique dielectric crystal will be of great advantage for numerous nanophotonic applications in the mid‐IR.
Ubiquitous Aluminum(III)‐TADF Complex as Sensitizer for Highly Efficient Solution‐Processed Hyperfluorescent OLEDs with Narrow Emission
Authors: Hoshi Keigo , Sasabe Hisahiro , Chiba Yudai , Yoshida Naoto , Nakamura Takeru , Nagasawa Keisuke , Sayama Yuya , Katagiri Hiroshi , Kido Junji 
Published: February 2024

AbstractAlthough Earth‐abundant, ubiquitous, metal‐based thermally activated delayed fluorescence (TADF) complexes are among the most promising candidate materials for next‐generation organic light‐emitting devices (OLEDs), few complexes are explored. Herein, a highly emissive aluminum(III)‐TADF complex—Al(MCzDBM)3—with three β‐diketone ligands is presented as a sensitizer for multiresonance (MR)‐TADF emitters. This complex exhibited green emission with suitable photophysical functions as a sensitizer, such as a high photoluminescent quantum yield (PLQY) of up to 97% with reduced aggregation‐caused quenching, a high radiative rate constant (kr) of 5.6 × 107 s−1, and a short delayed lifetime (τd) of 4.0 µs in the solid state. A solution‐processed Al(MCzDBM)3‐based OLED exhibited an external quantum efficiency (EQE) of 23.6%. This complex sensitized a yellow MR‐TADF emitter, yielding a near‐unity PLQY, and is used to fabricate a solution‐processed hyperfluorescent OLED with an EQE of 21.6% and full width at half maximum of 45 nm.
Generalized Drude–Lorentz Model Complying with the Singularity Expansion Method
Authors: Ben Soltane Isam , Dierick Félice , Stout Brian , Bonod Nicolas 
Published: February 2024

AbstractDeriving analytical expressions of dielectric permittivities is required for numerical and physical modeling of optical systems and the soar of non‐Hermitian photonics motivates their prolongation in the complex plane. Analytical models are based on the association of microscopic models to describe macroscopic effects. However, the question is to know whether the resulting Debye–Drude–Lorentz models are not too restrictive. Here, it is shown that the permittivity must be treated as a meromorphic transfer function that complies with the requirements of complex analysis. This function can be naturally expanded on a set of complex singularities. This singularity expansion of the dielectric permittivity allows to derive a generalized expression of the Debye–Drude–Lorentz model that complies with the requirements of complex analysis and the constraints of physical systems. It is shown that the complex singularities and other parameters of this generalized expression can be retrieved from experimental data acquired along the real frequency axis. The accuracy of this expression is assessed for a wide range of materials including metals, 2D materials and dielectrics, and it is shown how the distribution of the retrieved poles helps in characterizing the materials.
Defibrillated Lignocellulose Recovery Guided by Plant Chemistry and Anatomy – A Pioneering Study with Lupinus angustifolius
Authors: Schmidt Alina E.M. , Choong Ferdinand X. , Richter‐Dahlfors Agneta , Edlund Ulrica 
Published: February 2024

AbstractThe strive toward sustainability increases the demand for bio‐based material production, forcing expansion of the biorefinery feedstock supply from forest wood to non‐woody materials such as agricultural residues. As a model organism for legume crops, the aptness of agricultural lupins as a lignocellulose feedstock is investigated. Principle chemical analysis combined with optotracing, in which the fluorescent tracer molecule Carbotrace 680 generates a visual map of the native tissues’ lignocellulose anatomy at sub‐cellular resolution, enables informed design of a mild recovery process. A streamlined conversion approach is then designed, yielding lignin‐containing microfibrillated cellulose. By monitoring defibrillation and delignification throughout the extraction process, the use of optotracing for non‐destructive fiber analytics at unprecedented details across all hierarchical structures of lignocellulosic materials is demonstrated. This crop valorization is a prime illustration of a holistic use of lupin biomass, with seeds serving as plant‐based food sources, and other parts as sources for lignocellulose‐based materials, thereby expanding both the biorefinery concept and feedstock supply.
Experimental and Computational Study of Mg and Ta‐Doped Li7La3Zr2O12 Garnet‐Type Solid Electrolytes for All‐Solid‐State Lithium Batteries
Authors: Ma Kai , Chen Bowen , Li Cheng‐Xin , Thangadurai Venkataraman 
Published: February 2024

AbstractGarnet‐type Li7La3Zr2O12 electrolytes have garnered significant attention as promising solid‐state electrolyte candidates in all‐solid‐state lithium batteries (ASSLBs). However, its susceptibility to forming Li2CO3 upon atmospheric exposure leads to performance degradation, limiting its application. This study introduces a co‐doping strategy of Mg and Ta to enhance the properties of garnet electrolytes. Pure cubic Mg and Ta‐doped LLZO electrolytes are successfully synthesized using the solid‐state reaction method. Experimental results, coupled with density functional theory (DFT) calculation, reveal that Mg2+ doping occurs primarily at the La site (24c). This substitution, given the substantial disparity in ionic radii between Mg2+ and La3+, effectively narrows the transport bottleneck for Li‐ions, resulting in a decreased ionic conductivity and an increased activation energy. Li6.6La2.8Mg0.2Zr1.4Ta0.6O12 exhibits a relative density of ≈92.6%, demonstrating outstanding performance with a room temperature ionic conductivity of 4.31 × 10−4 S cm−1 and low electronic conductivity of 2.48 × 10−8 S cm−1. Notably, after 4 months of atmospheric exposure, its ionic conductivity decreased to ≈78% of the initial value, attributable to Li2CO3 formation. Furthermore, the material demonstrated exceptional long‐term cycle stability over 1000 h at a current density of 0.1 mA cm−2 at 25 °C, indicating effective suppression of Li dendrite formation.
Intelligent Situation Awareness Based on the Fractal Dimension and Multidimensional Reconstruction
Authors: Wang Peiyuan , Yuan Zhan , Jia Li , Wang Peibing , Guan Xin 
Published: February 2024

AbstractIn order to realize autonomy and intelligence for situation awareness, this paper proposes an intelligent situation awareness model based on fractional dimension information mining and multidimensional information reconstruction. First, some new concepts are proposed, the spatial situation perception is established by 3D reconstruction of the input fusion information, 4D reconstruction completes the situation comprehension and 5D reconstruction seeks the situation prediction. The three‐level situation estimation model is optimized to a more robust flexible model. Combined with the database system, the reasoning learning mechanism, and the diversified human‐machine interface concept, a basic framework of intelligent situation awareness is constructed. Second, the basic process of intelligent situation awareness is provided. Third, based on the flexible configuration method of the situation awareness system and the concept of unmanned weight determination for the situation awareness agents, an efficiency measurement model for the intelligent situation awareness model is also constructed, and an evaluation method for the consistency of multinode intelligent situation awareness is also provided. Fourth, the paper gives a typical electromagnetic situation estimation example for a drilling platform to explain and validate the concepts. Finally, several suggestions are put forward for the next construction of an intelligent situation awareness system.
Doping‐Induced Performance Improvement in ReS2 Field Effect Transistors: Exploring a Heterostructure with In2O3 Quantum Dots
Authors: Cho Hyeran , You Seung Yeol , Kim Gyu‐Tae 
Published: February 2024

AbstractRhenium disulfide (ReS2) is a type of transition metal dichalcogenides (TMDs) that has potential electronic and photoelectrical applications. However, limited research has been conducted on improving its electrical properties and understanding the effect of doping on ReS2‐based devices. In this study, the enhanced electrical and photoelectrical performance of a 2D/0D heterostructure constructed by decorating the In2O3 quantum dots (QDs) on a multilayer ReS2 field‐effect transistor (FET) is reported. The In2O3 QDs are characterized by using a transmission electron microscope, optical absorption, and photoluminescence spectroscopy. The n‐doping effects with improved mobility are clearly observed, which is attributed to the electron transfer induced by the relatively high conduction band level of In2O3 QDs. Owing to the channel migration of ReS2 and traps at the ReS2/In2O3 QDs interface, additional performance improvements are observed, including reduced contact resistance, improved subthreshold swing, and increased photoresponsivity; however, the photoresponse speed is decreased. In summary, the findings suggest a novel mixed‐dimensional heterostructure for enhancing the performance of ReS2 transistors and provide insights into doping‐induced channel migration for 2D materials.
An analysis of tax benefits by race and ethnicity for farm households
Authors: McDonald Tia M. , Durst Ron 
Published: February 2024

AbstractThis research simulates the impact on tax liabilities of five tax provisions that provide benefits to farm households by race and ethnicity. Using pooled data from the Agricultural Resource Management Survey (2017–2021), we find that, relative to White non‐Hispanic principal operator farm households, certain business tax benefits are less prevalent and of lower value for Hispanic, African American, and Native American principal operator farm households due to differences in income and investment levels. Household tax credits are significantly higher for Hispanic and Native American principal operator farm households and Asian principal operator farm households have significantly higher total tax benefits from the five provisions examined.
Safety and long‐term survival results of the addition of inotuzumab ozogamicin to the conditioning regimen of allogeneic stem cell transplantation: A single‐center phase 1,2 trial
Authors: Khouri Issa F. , Alzahrani Kamal , Kantarjian Hagop , Milton Denái R. , Gulbis Alison M. , Sasaki Koji , Jain Nitin , Short Nicholas J. , Kadia Tapan , Daher May , Rafei Hind , Im Jin S. , Marin David , Olson Amanda L. , Popat Uday , Qazilbash Muzaffar , Ramdial Jeremy , Rondon Gabriela , Srour Samer , Kebriaei Partow , Shpall Elizabeth , Champlin Richard , Jabbour Elias J. 
Published: February 2024

AbstractHere we report on the first prospective study evaluating the safety and long‐term survival when an escalating dose of inotuzumab ozogamicin (INO) (0.6, 1.2, or 1.8 mg/m2 on day 13) was added to one alkylator‐containing conditioning regimen in patients with relapsed CD22 (+) lymphoid malignancies who were candidates for hematopoietic stem cell transplantation (HSCT). Twenty‐six patients were enrolled. Six (23%) of these patients entered the phase 1 study: four were treated at an INO dose of 0.6 mg/m2 and two at dose of 1.2 mg/m2. None of these patients experienced dose‐limiting toxicities. The remaining 20 (77%) patients entered the phase 2 part of the study at the maximum dose of 1.8 mg/m2. One patient developed VOD; this patient had received nivolumab immediately before HSCT while simultaneously experiencing hyperacute graft‐vs‐host disease (GVHD). Treatment‐related mortality (TRM) at 5 years was 12%. With a median follow‐up of 48.7 months, the 5‐year overall survival (OS) and progression‐free survival (PFS) rates were 84% and 80%, respectively. Compared with a historical cohort who received same conditioning for HSCT but without INO (n = 56), the INO group showed no significant differences in incidence of liver toxicity, engraftment time, TRM, or risk of acute GVHD. Patients with lymphoma who received INO had a trend for a better 5‐year OS (93% versus 68%) and PFS (93% versus 58%) than those in the control group. In conclusion, our results showed that INO is safe with no increased risk of VOD when combined with one alkylator‐containing regimen of HSCT.
Iron restriction in sickle cell disease: When less is more
Authors: Castro Oswaldo L. , De Franceschi Lucia , Ganz Tomas , Kanter Julie , Kato Gregory J. , Pasricha Sant‐Rayn , Rivella Stefano , Wood John C. 
Published: February 2024

AbstractPrimum non nocere! Can iron deficiency, an abnormality that causes anemia, benefit people with sickle cell disease (SCD) who already have an anemia? The published literature we review appears to answer this question in the affirmative: basic science considerations, animal model experiments, and noncontrolled clinical observations all suggest a therapeutic potential of iron restriction in SCD. This is because SCD's clinical manifestations are ultimately attributable to the polymerization of hemoglobin S (HbS), a process strongly influenced by intracellular HbS concentration. Even small decrements in HbS concentration greatly reduce polymerization, and iron deficiency lowers erythrocyte hemoglobin concentration. Thus, iron deficiency could improve SCD by changing its clinical features to those of a more benign anemia (i.e., a condition with fewer or no vaso‐occlusive events). We propose that well‐designed clinical studies be implemented to definitively determine whether iron restriction is a safe and effective option in SCD. These investigations are particularly timely now that pharmacologic agents are being developed, which may directly reduce red cell hemoglobin concentrations without the need for phlebotomies to deplete total body iron.
Cortical bone architecture of hominid intermediate phalanges reveals functional signals of locomotion and manipulation
Authors: Syeda Samar M. , Tsegai Zewdi J. , Cazenave Marine , Skinner Matthew M. , Kivell Tracy L. 
Published: February 2024

AbstractObjectivesReconstruction of fossil hominin manual behaviors often relies on comparative analyses of extant hominid hands to understand the relationship between hand use and skeletal morphology. In this context, the intermediate phalanges remain understudied. Thus, here we investigate cortical bone morphology of the intermediate phalanges of extant hominids and compare it to the cortical structure of the proximal phalanges, to investigate the relationship between cortical bone structure and inferred loading during manual behaviors.Materials and MethodsUsing micro‐CT data, we analyze cortical bone structure of the intermediate phalangeal shaft of digits 2–5 in Pongo pygmaeus (n = 6 individuals), Gorilla gorilla (n = 22), Pan spp. (n = 23), and Homo sapiens (n = 23). The R package morphomap is used to study cortical bone distribution, cortical thickness and cross‐sectional properties within and across taxa.ResultsNon‐human great apes generally have thick cortical bone on the palmar shaft, with Pongo only having thick cortex on the peaks of the flexor sheath ridges, while African apes have thick cortex along the entire flexor sheath ridge and proximal to the trochlea. Humans are distinct in having thicker dorsal shaft cortex as well as thick cortex at the disto‐palmar region of the shaft.DiscussionVariation in cortical bone distribution and properties of the intermediate phalanges is consistent with differences in locomotor and manipulative behaviors in extant great apes. Comparisons between the intermediate and proximal phalanges reveals similar patterns of cortical bone distribution within each taxon but with potentially greater load experienced by the proximal phalanges, even in knuckle‐walking African apes. This study provides a comparative context for the reconstruction of habitual hand use in fossil hominins and hominids.
Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer's disease
Authors: Wang Guoqiao , Li Yan , Xiong Chengjie , Benzinger Tammie L. S. , Gordon Brian A. , Hassenstab Jason , Aschenbrenner Andrew J. , McDade Eric , Clifford David B. , Libre‐Guerra Jorge J. , Shi Xinyu , Mummery Catherine J. , van Dyck Christopher H. , Lah James J. , Honig Lawrence S. , Day Gregg , Ringman John M. , Brooks William S. , Fox Nick C. , Suzuki Kazushi , Levin Johannes , Jucker Mathias , Delmar Paul , Bittner Tobias , Bateman Randall J. ,   for the DIAN‐TU Study Team
Published: February 2024

AbstractINTRODUCTIONIncreasing evidence suggests that amyloid reduction could serve as a plausible surrogate endpoint for clinical and cognitive efficacy. The double‐blind phase 3 DIAN‐TU‐001 trial tested clinical and cognitive declines with increasing doses of solanezumab or gantenerumab.METHODSWe used latent class (LC) analysis on data from the Dominantly Inherited Alzheimer Network Trials Unit 001 trial to test amyloid positron emission tomography (PET) reduction as a potential surrogate biomarker.RESULTSLC analysis categorized participants into three classes: amyloid no change, amyloid reduction, and amyloid growth, based on longitudinal amyloid Pittsburgh compound B PET standardized uptake value ratio data. The amyloid‐no‐change class was at an earlier disease stage for amyloid amounts and dementia. Despite similar baseline characteristics, the amyloid‐reduction class exhibited reductions in the annual decline rates compared to the amyloid‐growth class across multiple biomarker, clinical, and cognitive outcomes.DISCUSSIONLC analysis indicates that amyloid reduction is associated with improved clinical outcomes and supports its use as a surrogate biomarker in clinical trials.Highlights
We used latent class (LC) analysis to test amyloid reduction as a surrogate biomarker.
Despite similar baseline characteristics, the amyloid‐reduction class exhibited remarkably better outcomes compared to the amyloid‐growth class across multiple measures.
LC analysis proves valuable in testing amyloid reduction as a surrogate biomarker in clinical trials lacking significant treatment effects.