bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE EXPEDIENCY OF INCLUDING AN INDIVIDUAL SCIENTIFIC WORK AS A MANDATORY COMPONENT IN THE EDUCATIONAL AND PROFESSIONAL PROGRAM OF MEDICINE
Authors: Akimov O.Y. , Mishchenko A.V. , Solovyova N.V. , Nazarenko S.M. , Zakolodna O.E. , Kostenko V.O. 
Published: March 2024

Among the tasks of the "Concept of Sustainable Development", it is worth highlighting tasks 3 and 4: "Good health and well-being" and "Quality education". In this way, the training of students under the educational and professional program "Medicine" at the Poltava State Medical University meets two tasks from the "Concept of Sustainable Development".
Modern specialists of the medical profile are in the conditions of the need to use a scientific approach and elements of critical thinking in their professional activities. At this stage, the educational and professional program "Medicine", which provides for the training of students at the Poltava State Medical University, does not include educational components that provide students with competencies related to scientific activity (scientific writing, critical analysis of literary sources, methods of scientific research).
The purpose of this work is to justify the feasibility of including the mandatory component "Scientific training" developed on the basis of the mandatory component "Pathophysiology" in the educational and professional program "Medicine" at the Poltava State Medical University.
The article uses general scientific theoretical research methods such as: analysis, synthesis, comparison of concepts, abstraction and generalization.
We offer the following structure of the compulsory component "Scientific training", which consists of the following modules: Module 1 "Modeling of typical pathological processes in various organs and systems", Module 2 "Methods for the study of pathological changes in organs and systems", Module 3 "Principles of pathogenetic correction of typical pathological processes" and Module 4 "Methodical approach to the analysis of obtained experimental results". The total number of credits provided for studying the compulsory component "Scientific training" is 16 credits in accordance with the European credit transfer system. Approximately 2/3 of the hours provided for the study of the mandatory component "Scientific training" are planned to be used for independent work by students of higher education. Such a number of hours for independent work is argued by the need to write an individual research paper, which is an analogue of a master's thesis in other specialties.
Modernization of the educational and professional program "Medicine" by including the mandatory component "Scientific training" is a promising way of improving the quality of education for students of the II (master's) level studying in the specialty 222 "Medicine".
purpose of cooperation, solidarity, Solidarity and Forgiveness it in stories of the prophets in the Holy Qur'an
Authors: Hussein Ahmed Oleiwi , Abdulrahman Alhassan Ali 
Published: March 2024

Islam came with legislation that urges people to do good, and prevents them and discourages them from doing evil. It is known from the religion by necessity, that all the rulings legislated in our religion are in various aspects; It is only prescribed to bring benefit to them, and repel corruption from them in religion and this world. The stories of the prophets carry great meanings and goals, which are expressed through exhortations and sermons. We draw great lessons from it. It is an applied example that tightens the buttons and sharpens the determination, when the Muslim learns about the history of the previous nations. We discussed important legal purposes from the general and comprehensive purposes of Sharia, even if the sayings of scholars differed in counting them among them. Scholars have proven that the rulings in Islamic Sharia are legislated and linked to goals, objectives and meanings that are inseparable from achieving interests and warding off evils from people in both worlds .
The research consists of two sections, and it shows various general legal purposes. We sought to extract it from the Quranic stories that tell the stories of the prophets. We worked on extracting these purposes from the jurists' deduction of the rulings mentioned in those stories. The value and importance of writing lies in the jurists’ protest and inference from some of the rulings mentioned in those stories; They deduced some of the legal rulings from them, taking into account the possibility of inferring the evidence of laws from us in terms of acceptance and rejection. And that one of the advantages of the stories of the prophets contained in the Qur’anic stories is the power of influence in the hearts of Muslims, as it represents a great ideological and educational incentive .
The Effectiveness of Baby Massage in Increasing Infant's Body Weight
Authors: Sirait Lusiana Lusia , Simatupang Gusti Seventina 
Published: March 2024

Increasing body weight is an indicator for assessing baby growth. The baby's weight gain in the first year of life is based on whether the baby receives good nutrition from birth to the first six months. The weight gain per week ranges from 140-200 grams. Children 1-12 months experience rapid growth, so it is necessary to maintain the baby's weight according to age. They obtain optimal growth and development results from the interaction of several interrelated factors: genetic factors, nutrition, socio-economic status, health status, hormonal factors, environmental factors, cultural environment, parenting patterns, physical activity, and stimulation. Dietary factors play an essential role in the growth process because they influence the nutritional status of children. Stimulation factors are also critical to stimulate children's growth. Massage is a technique that combines the physical benefits of human touch with emotional benefits such as bonding and weight gain. This research aims to determine the relationship between baby massage and weight gain in babies at the Kasih Bunda Clinic in 2023. This type of research is the Shapiro-Wilk Test with a non-equivalent control group design and a pretest-posttest design. Then, measurements were taken before the pretest on both groups of respondents; then, measurements were carried out again (Posttest) to determine the difference in pretest and posttest body weight. The type of sampling uses purposive sampling. The results of the research were carried out with a confidence level of 95% (α=0.05), as proven by the p-value: 0.000 (p-value ≤ 0.05). In conclusion, a relationship exists between giving baby massages and increasing baby weight at the Kasih Bunda Clinic in 2023. It is hoped that health workers will make baby massage one of the counseling materials for mothers to support the increase in baby weight and teach them how to do proper baby massage.
María Fernanda Ampuero y la narrativa del disgusto: Pelea de gallos y Sacrificios humanos
Authors: Jossa Emanuela 
Published: March 2024

A partir de las aportaciones de las teorías de los afectos que plantean la superación del enfoque dualista sobre pasividad y agencia, afectos negativos y catárticos, este trabajo analiza uno de los afectos negativos menos estudiados, el asco. En la primera parte, se describe sintéticamente la repugnancia a partir de los estudios de Kolnai, Miller, Ahmed, Ngai. Luego el artículo se centra en las dos colecciones de cuentos de María Fernanda Ampuero, Pelea de gallos (2018) y Sacrificios humanos (2021), que presentan una marcada insistencia en la representación de la repugnancia. A través de las percepciones sensoriales, especialmente el olfato, la autora hace ostensible el asco, desafiando al lector. La intención del presente trabajo es abordar los textos tanto desde la representación como desde la recepción, para indagar la función de este afecto y averiguar si el asco implica solamente rechazo o también un antagonismo, una propuesta disyuntiva con respecto de la normatividad de los espacios íntimos y públicos de la contemporaneidad.
Guerra Fria em Gotham City
Authors: Maynard Dilton Cândido Santos , Silva Diego Leonardo Santana 
Published: March 2024

Resumo: Este artigo tem como objetivo analisar como elementos do conflito ideológico e propagandístico norte-americano da Guerra Fria aparecem na História em Quadrinho (HQ) intitulada O Cavaleiro das Trevas, de Frank Miller, lançada em 1986. À medida em que boa parte da segunda metade do século XX foi influenciada direta ou indiretamente pela Guerra Fria, torna-se previsível que manifestações culturais e artísticas também carregassem em si representações desse conflito. Nisso, filmes, séries de TV, livros e HQ contaram com estórias que ilustraram personagens e acontecimentos que remetem a eventos do conflito entre americanos e soviéticos. Acreditamos que O Cavaleiro das Trevas é uma fonte valiosa para estudos desse tipo. A trama mistura elementos tradicionais das HQ estando repleta de heróis alienígenas, vigilantes, alta tecnologia, com conflitos extremamente mascarados humanos e farpas à sociedade americana dos anos 80, sobretudo à classe política.

Palavras-chave: Batman; DC Comics; Guerra Fria; História em Quadrinhos; O Cavaleiro das Trevas.

Referências Bibliográficas
BARBROOK, Richard. Futuros imaginários-Das máquinas pensantes à aldeia global. Editora Peirópolis LTDA, 2009.
HOBSBAWM, Eric. As Artes 1914-45. Era dos Extremos: o breve século XX (1914-1991). São Paulo: Cia das Letras, 1995.
JUDT, Tony. Pós-Guerra. Uma história da Europa desde 1945. Rio de Janeiro: Objetiva, 2008.
JUDT, Tony. Quando Os Fatos Mudam: Ensaios 1995-2010. Rio de Janeiro: Objetiva, 2016.
MUNHOZ, Sidnei. Guerra Fria: um debate interpretativo. In: SILVA, Francisco C. T. (org). O Século Sombrio: uma história geral do século XX. Rio de Janeiro: Elsevier, 2004.
MUNHOZ, Sidnei. Guerra Fria: História e Historiografia. Curitiba: Editora Appris, 2020
ROBB, Brian J. A identidade secreta dos super-heróis: a história e as origens dos maiores sucessos das HQ's: do super-homem aos vingadores. Rio de Janeiro: Valentina, 2017. [Recurso Eletrônico]
WELDON, Glen. Superman: uma biografia não autorizada.

Sitiografia
COMICHRON. Site especializado em número de vendas de HQ. Disponível em: https://www.comichron.com. Acesso em 04 de fev. de 2023.
REVISTA GALILEU. Revista educacional. Disponível em: https://revistagalileu.globo.com. Acesso em 04 de fev. de 2023.
THE NUMBERS, site especializado bilheteria cinematográfica. Disponível em: https://www.the-numbers.com. Acesso em 04 de fev. de 2023.

Fonte
MILLER, Frank. O Cavaleiro das Trevas. São Paulo: Editora Abril/DC Comics, 1997.
POLÍTICAS PÚBLICAS E SUSTENTABILIDADE NO BRASIL – Resenha de Governança e Sustentabilidade: um elo necessário no Brasil
Authors: Cavalcanti Maralysa Correia de Souza 
Published: March 2024

POLÍTICAS PÚBLICAS E SUSTENTABILIDADE NO BRASIL – Resenha de Governança e Sustentabilidade: um elo necessário no Brasil
Sumário do livro
Governança e sustentabilidade: por que este tema importa no Brasil?
Governança no setor público
Sustentabilidade no setor público
Relatórios de sustentabilidade: reflexões necessárias
Instrumentos de governança e de sustentabilidade
Governança e sustentabilidade: o elo necessário

REFERÊNCIAS
CADER, Renato; VILLAC, Teresa. Governança e Sustentabilidade. 1Reimp. Belo Horizonte: Fórum, 2022. 155p. ISBN 978-65-5518-395-5
EFEKTIVITAS PENYULUHAN DAN KONSELING PADA PEMILIHAN METODE KONTRASEPSI PASANGAN SUAMI-ISTRI DAN PENGARUHNYA TERHADAP TINGKAT KEPUASAN SEKSUAL
Authors: Wati Irma 
Published: March 2024

penelitian yang digunakan adalah Kuantitatif dengan metode Analitik Prospektif. Tekhnik sampling dengan konsekuatif sapling sebanyak 33 suami. Tujuan adalah mengetahui efektivitas penyuluhan dan konseling pada pemilihan metode kontrasepsi pasangan suami-istri dan pengaruhnya terhadap tingkat kepuasan seksual. Metode Penelitian : Penelitian dilaksanakan pada bulan April-Juni 2019 (16 minggu).Instrumen yang digunakan adalah kuesioner. Hasil penelitian terdapat peningkatan pengetahuan KB suami dari 60% menjadi 100%. Sebanyak 91% istri minta izin kepada suami saat berKB, sebanyak 48,5% subyek yang berKB dimana suami yang memutuskan alat KB yang digunakan sedangkan 51,5% diputuskan oleh istri, Sebanyak 25 (75,8%) suami berdiskusi dengan istri setelah menggunakan KB, Sebanyak 24 (72,7%) suami menyerahkan sepenuhnya keputusan berKB kepada istri, tidak ada gangguan hubungan seksual selama berKB pada spiral sebanyak 87,5%. Implikasi penelitian : subyek yang ada gangguan terbanyak ditemukan yaitu senggama terputus sebesar 66,7% dan kondom 50%, Jenis KB dengan presentasi tidak ada penurunan kenikmatan hubungan seksual selama berKB pada spiral 87,5%. Sedangkan yang subyek yang ada penurunan terbanyak ditemukan pada yang tidak menggunakan alat KB yaitu senggama terputus sebesar 66,6 % dan kondom 50%. Rekomendasi : untuk penelitian selanjutnya untuk bisa mengembangkan metode-metode lainnya.
Effects of 12-week gait retraining on plantar flexion torque, architecture, and behavior of the medial gastrocnemius in vivo
Authors: Zhang Chuyi , Deng Liqin , Zhang Xini , Wu Kaicheng , Zhan Jianglong , Fu Weijie , Jin Jing 
Published: March 2024

Objective:This study aims to explore the effects of 12-week gait retraining (GR) on plantar flexion torque, architecture, and behavior of the medial gastrocnemius (MG) during maximal voluntary isometric contraction (MVIC).Methods:Thirty healthy male rearfoot strikers were randomly assigned to the GR group (n = 15) and the control (CON) group (n = 15). The GR group was instructed to wear minimalist shoes and run with a forefoot strike pattern for the 12-week GR (3 times per week), whereas the CON group wore their own running shoes and ran with their original foot strike pattern. Participants were required to share screenshots of running tracks each time to ensure training supervision. The architecture and behavior of MG, as well as ankle torque data, were collected before and after the intervention. The architecture of MG, including fascicle length (FL), pennation angle, and muscle thickness, was obtained by measuring muscle morphology at rest using an ultrasound device. Ankle torque data during plantar flexion MVIC were obtained using a dynamometer, from which peak torque and early rate of torque development (RTD50) were calculated. The fascicle behavior of MG was simultaneously captured using an ultrasound device to calculate fascicle shortening, fascicle rotation, and maximal fascicle shortening velocity (Vmax).Results:After 12-week GR, 1) the RTD50 increased significantly in the GR group (p = 0.038), 2) normalized FL increased significantly in the GR group (p = 0.003), and 3) Vmax increased significantly in the GR group (p = 0.018).Conclusion:Compared to running training, GR significantly enhanced the rapid strength development capacity and contraction velocity of the MG. This indicates the potential of GR as a strategy to improve muscle function and mechanical efficiency, particularly in enhancing the ability of MG to generate and transmit force as well as the rapid contraction capability. Further research is necessary to explore the effects of GR on MG behavior during running in vivo.
Development of high-efficiency superparamagnetic drug delivery system with MPI imaging capability
Authors: Bai Shi , Zhang Xiao-dan , Zou Yu-qi , Lin Yu-xi , Liu Zhi-yao , Li Ke-wen , Huang Ping , Yoshida Takashi , Liu Yi-li , Li Ming-shan , Zhang Wei , Wang Xiao-ju , Zhang Min , Du Cheng 
Published: March 2024

In this study, a high-efficiency superparamagnetic drug delivery system was developed for preclinical treatment of bladder cancer in small animals. Two types of nanoparticles with magnetic particle imaging (MPI) capability, i.e., single- and multi-core superparamagnetic iron oxide nanoparticles (SPIONs), were selected and coupled with bladder anti-tumor drugs by a covalent coupling scheme. Owing to the minimal particle size, magnetic field strengths of 270 mT with a gradient of 3.2 T/m and 260 mT with a gradient of 3.7 T/m were found to be necessary to reach an average velocity of 2 mm/s for single- and multi-core SPIONs, respectively. To achieve this, a method of constructing an in vitro magnetic field for drug delivery was developed based on hollow multi-coils arranged coaxially in close rows, and magnetic field simulation was used to study the laws of the influence of the coil structure and parameters on the magnetic field. Using this method, a magnetic drug delivery system of single-core SPIONs was developed for rabbit bladder therapy. The delivery system consisted of three coaxially and equidistantly arranged coils with an inner diameter of Φ50 mm, radial height of 85 mm, and width of 15 mm that were positioned in close proximity to each other. CCK8 experimental results showed that the three types of drug-coupled SPION killed tumor cells effectively. By adjusting the axial and radial positions of the rabbit bladder within the inner hole of the delivery coil structure, the magnetic drugs injected could undergo two-dimensional delivery motions and were delivered and aggregated to the specified target location within 12 s, with an aggregation range of about 5 mm × 5 mm. In addition, the SPION distribution before and after delivery was imaged using a home-made open-bore MPI system that could realistically reflect the physical state. This study contributes to the development of local, rapid, and precise drug delivery and the visualization of this process during cancer therapy, and further research on MPI/delivery synchronization technology is planned for the future.
Construction of recombinant pseudorabies virus expressing PCV2 Cap, PCV3 Cap, and IL-4: investigation of their biological characteristics and immunogenicity
Authors: Yang Yanting , Xu Zhiwen , Tao Qian , Xu Lei , Gu Sirui , Huang Yao , Liu Zheyan , Zhang Yang , Wen Jianhua , Lai Siyuan , Zhu Ling 
Published: March 2024

BackgroundPorcine circovirus type 2 (PCV2) is a globally prevalent and recurrent pathogen that primarily causes slow growth and immunosuppression in pigs. Porcine circovirus type 3 (PCV3), a recently discovered virus, commonly leads to reproductive disorders in pigs and has been extensively disseminated worldwide. Infection with a single PCV subtype alone does not induce severe porcine circovirus-associated diseases (PCVD), whereas concurrent co-infection with PCV2 and PCV3 exacerbates the clinical manifestations. Pseudorabies (PR), a highly contagious disease in pigs, pose a significant threat to the swine industry in China.MethodsIn this study, recombinant strains named rPRV-2Cap/3Cap and rPRV-2Cap/3Cap/IL4 was constructed by using a variant strain XJ of pseudorabies virus (PRV) as the parental strain, with the TK/gE/gI genes deleted and simultaneous expression of PCV2 Cap, PCV3 Cap, and IL-4. The two recombinant strains obtained by CRISPR/Cas gE gene editing technology and homologous recombination technology has genetic stability in baby hamster Syrian kidney-21 (BHK-21) cells and is safe to mice.ResultsrPRV-2Cap/3Cap and rPRV-2Cap/3Cap/IL4 exhibited good safety and immunogenicity in mice, inducing high levels of antibodies, demonstrated 100% protection against the PRV challenge in mice, reduced viral loads and mitigated pathological changes in the heart, lungs, spleen, and lymph nodes during PCV2 challenge. Moreover, the recombinant viruses with the addition of IL-4 as a molecular adjuvant outperformed the non-addition group in most indicators.ConclusionrPRV-2Cap/3Cap and rPRV-2Cap/3Cap/IL4 hold promise as recombinant vaccines for the simultaneous prevention of PCV2, PCV3, and PRV, while IL-4, as a vaccine molecular adjuvant, effectively enhances the immune response of the vaccine.
Identification of germline population variants misclassified as cancer-associated somatic variants
Authors: Pollard Rebecca D. , Wilkerson Matthew D. , Rajagopal Padma Sheila 
Published: March 2024

IntroductionDatabases used for clinical interpretation in oncology rely on genetic data derived primarily from patients of European ancestry, leading to biases in cancer genetics research and clinical practice. One practical issue that arises in this context is the potential misclassification of multi-ancestral population variants as tumor-associated because they are not represented in reference genomes against which tumor sequencing data is aligned.MethodsTo systematically find misclassified variants, we compared somatic variants in census genes from the Catalogue of Somatic Mutations in Cancer (COSMIC) V99 with multi-ancestral population variants from the Genome Aggregation Databases’ Linkage Disequilibrium (GnomAD). By comparing genomic coordinates, reference, and alternate alleles, we could identify misclassified variants in genes associated with cancer.ResultsWe found 192 of 208 genes in COSMIC’s cancer-associated census genes (92.31%) to be associated with variant misclassifications. Among the 1,906,732 variants in COSMIC, 6,957 variants (0.36%) aligned with normal population variants in GnomAD, concerning for misclassification. The African / African American ancestral population included the greatest number of misclassified variants and also had the greatest number of unique misclassified variants.ConclusionThe direct, systematic comparison of variants from COSMIC for co-occurrence in GnomAD supports a more accurate interpretation of tumor sequencing data and reduces bias related to genomic ancestry.
A poor prognostic male choriocarcinoma with multiple systemic metastases: a case report and the literature review
Authors: Huang Wenpeng , Zheng Zuohuan , Bao Zheng , Xiao Xiaoyan , Li Liming , Sun Zhaonan , Kang Lei 
Published: March 2024

BackgroundNon-gestational choriocarcinoma, also known as primary choriocarcinoma, is extremely rare in men, manifesting with specific signs such as breast feminization, testicular atrophy, and loss of libido. The presentation typically includes elevated serum β-hCG levels, widespread metastatic disease, and a rapid progression of the condition.Case reportWe present a rare case of a 41-year-old man diagnosed with choriocarcinoma, exhibiting a unique combination of multiple metastases, including lung, brain, bone, and retroperitoneal lymph node metastases, as confirmed by 18F-FDG PET/CT imaging. The patient was treated with aggressive chemotherapy and pembrolizumab, and the prognosis remained poor. The patient’s overall survival was a mere 5 months following diagnosis.ConclusionNon-gestational choriocarcinoma represents a rare entity in clinical practice and should be considered in young men presenting with gynaecomastia and elevated β-hCG levels alongside normal gonads. Thus, we advocate for a more comprehensive inquiry into medical history and a systematic examination. The 18F-FDG PET/CT examination not only visually delineates the lesion’s location and extent but also serves as a cornerstone for clinical tumor staging, providing valuable support for treatment monitoring and subsequent follow-up.