bluuebunny/crossref_metadata_2025_split huggingface dataset:
Queering the humanitarian principles of neutrality and impartiality: Implications for humanitarian action, IHL effectiveness and gender justice
Authors: Chernova Anna 
Published: April 2024

AbstractInstitutions are often reluctant to openly engage on controversies around the patriarchal underpinnings of the humanitarian sector, or the hard questions around implementing rights-based approaches in spaces where the dominant social norms run counter to an enabling environment for principled humanitarian and development assistance. A reluctance to engage on these issues can lead to unintended suppression of gender justice efforts under the urgency and scale of needs-based humanitarian response. Pre-crisis unequal power relations can be visible or invisible, difficult to measure and even more difficult to address through humanitarian action. Engaging on root causes and drivers of human suffering is often viewed as “political” in contexts of closing civic space and restricted humanitarian access. This article will explore tensions and synergies between the humanitarian principles and the gender justice agenda with a view to helping humanitarian actors contribute to long-term goals of transforming social norms. The article applies a critical feminist lens to the humanitarian principles of neutrality and impartiality, with a focus on the wider development agenda, the nature of the State in a State-centric global order, and the continuum of violence. Drawing on critical feminist theory and decolonization discourses, and building on gender analyses of international humanitarian law, this article looks to queer the humanitarian principles of neutrality and impartiality within the context of the shifting aid system in which they are applied. The objective is help address some of the gaps in literature, identify ways in which aid actors can reduce unintended harm to the gender justice agenda, and help contribute to the more transformative agendas of gender justice.
Radiative and Chemical Effects of Non‐Homogeneous Methane on Terrestrial Carbon Fluxes in Asia
Authors: Zhang Qian , Wang Tijian , Wu Hao , Qu Yawei , Xie Min , Li Shu , Zhuang Bingliang , Li Mengmeng , Kilifarska Natalya Andreeva 
Published: April 2024

AbstractMethane (CH4) plays a crucial role in shaping terrestrial ecosystems due to its radiative effect and atmospheric photochemical reactions. In this study, we employed an enhanced regional climate‐chemistry‐ecosystem model (RegCM‐Chem‐YIBs) to comprehensively evaluate the impacts of both radiative and chemical effects of CH4 on terrestrial carbon fluxes across the East, South, and Southeast Asia (EA, SA, SEA) during the year 2010. Our findings showed that the radiative effects of CH4 yielded a positive influence on carbon fluxes. Specifically, the EA region experienced a significant increase in the gross primary production (GPP), reaching up to 0.515 Pg C Yr−1. In comparison, the SEA region exhibited a decrease in the net ecosystem exchange (NEE) of approximately −0.066 Pg C Yr−1. Further analysis revealed that alterations in radiation and vapor pressure deficit (VPD) were dominant drivers. Conversely, the chemical effects of CH4 lead to heightened regional surface ozone (O3) concentrations (2.704–3.115 ppb) and generate a negative response in carbon fluxes. Within the SEA region, GPP observed a decrease of up to −0.144 Pg C Yr−1, while NEE displayed a significant increase of 0.022 Pg C Yr−1. Taken together, the combined radiative and chemical effects of CH4 indicated a positive impact on regional carbon fluxes, with GPP increasing by 0.632 Pg C Yr−1 and NEE decreasing by −0.09 Pg C Yr−1. This holistic perspective is crucial for comprehending the intricate interactions linking climate change, atmospheric pollution, and the global carbon cycle.
Changes in Stratospheric Dynamics Simulated by the EC‐Earth Model From CMIP5 to CMIP6
Authors: Serva F. , Christiansen B. , Davini P. , von Hardenberg J. , van den Oord G. , Reerink T. J. , Wyser K. , Yang S. 
Published: April 2024

AbstractThe simulated stratospheric dynamics have been improved compared to previous generations in many climate models taking part in the Coupled Model Intercomparison Project Phase 6 (CMIP6). This was achieved by going from low to high‐top configurations, that is, increasing the atmospheric vertical resolution, raising the model lid height and including parameterization schemes, such as non‐orographic gravity wave drag (GWD), to simulate small‐scale processes. This also applies to the EC‐Earth model, for which comprehensive analysis is now possible thanks to outputs archived within the Dynamics and Variability Model Intercomparison Project (DynVarMIP). Here we analyze atmosphere‐only simulations and evaluate the stratospheric dynamics of low‐top CMIP5 and high‐top CMIP6 configurations of EC‐Earth against the MERRA‐2 and ERA5 reanalyses. This allows us to identify and interpret model biases in the atmospheric component and to highlight deficiencies needed to be addressed in future model versions. We find substantial improvements in the simulation of the stratosphere in the CMIP6 configuration, both in the tropical and extratropical regions. The zonal wind momentum budget in the tropical stratosphere is much improved in the high‐top configuration. Seasonal variability of both models is qualitatively similar to the reanalysis, but for the low‐top model this is likely due to compensating errors, as its intraseasonal variability is less realistic. The non‐orographic GWD forcing is weak in the high‐top model and this limits the realism of the tropical stratosphere variability. We point to persisting issues in the stratosphere of EC‐Earth that should be tackled to improve hemispheric‐scale circulation and variability.
Remote Sensing of Multitemporal Functional Lake‐To‐Channel Connectivity and Implications for Water Movement Through the Mackenzie River Delta, Canada
Authors: Dolan W. , Pavelsky T. M. , Piliouras A. 
Published: April 2024

AbstractThe Mackenzie River Delta in Canada is a mediator of hydrological transport between the expansive Mackenzie River watershed and the Beaufort Sea. Within the delta, lakes frequently act as water and sediment traps, limiting or delaying the movement of material to the coastal ocean. The degree to which this filtering takes place depends on the ease with which sediment‐laden water is transported from distributary channels into deltaic lakes, referred to as functional lake‐to‐channel connectivity, which varies both spatially and temporally. Tracking of connectivity has previously been limited to either small regions of the delta or has focused on a snapshot of connectivity at a single instance in time. Here we describe an algorithm that uses Landsat imagery to track summertime functional lake‐to‐channel connectivity of 10,362 lakes between 1984 and 2022 on an image‐by‐image basis. We calculate a total average connected lake area of 1400.7 km2 during the 2 weeks after peak discharge, 763.6 km2 higher than previous estimates, suggesting a larger influence of connected lakes on water movement through the delta than previously estimated. We also identify water level thresholds that lead to the initiation of high sediment river water movement into 5,989 lakes (908 lakes with uncertainty ≤±0.5 m), and identify an additional 2899 lakes whose connectivity does not vary at all. As the Arctic hydrological cycle responds to climate change, this work lays a foundation for tracking the movement of water, and the matter it carries, from the Mackenzie River watershed to the Beaufort Sea.
Mesosphere and Lower Thermosphere Temperatures Simulated by WACCM‐X With NAVGEM‐HA Meteorological Analyses and Compared to SABER Observations
Authors: Liu Guiping , Klenzing Jeffrey H. , McDonald Sarah E. , Sassi Fabrizio , Rowland Douglas E. 
Published: April 2024

AbstractRealistic modeling of the dynamics and variability in the upper mesosphere and lower thermosphere (UMLT) is critical to understand the coupling between different layers of the whole atmosphere system. Here we present simulations of the UMLT temperatures at ∼100 km altitude for one year during 2014 by the Whole Atmosphere Community Climate Model with thermosphere‐ionosphere extension (WACCM‐X) constrained below ∼90 km using meteorological analysis products of the high‐altitude version of Navy Global Environmental Model (NAVGEM‐HA). The model results are sampled at the same times and latitudes and longitudes as the satellite observations from Thermosphere Ionosphere and Mesosphere Electric Dynamics/Sounding of the Atmosphere using Broadband Emission Radiometry (TIMED/SABER). Comparisons show that the observed and modeled daily zonal mean temperatures are correlated (r ∼0.5–0.7) at most latitudes between ±50°. Both the observations and simulations show an annual variation at mid‐latitudes in two hemispheres with the temperature maximum in summer and the minimum in winter, and at lower latitudes the semiannual variation becomes stronger having the temperature maximums at equinoxes and the minimums during solstices. However, the temperatures observed are on average ∼5–10 K (3%–5%) smaller than the model and the observations show a larger variability. Moreover, migrating tidal amplitudes are mostly overestimated by the model. Though differences are noticed, the WACCM‐X simulations with NAVGEM‐HA meteorological analyses are overall consistent with the SABER observations. These results support that whole atmosphere models informed by high altitude observations would help to simulate the UMLT variability and the atmosphere and ionosphere coupling.
Metabolic reprogramming regulated by TRAF6 contributes to the leukemia progression
Authors: Matsui Shinichiro , Ri Chihiro , Bolanos Lyndsey C. , Choi Kwangmin , Shibamiya Asuka , Ishii Arata , Takaishi Koji , Oshima-Hasegawa Nagisa , Tsukamoto Shokichi , Takeda Yusuke , Mimura Naoya , Yoshimi Akihide , Yokote Koutaro , Starczynowski Daniel T. , Sakaida Emiko , Muto Tomoya 
Published: April 2024

AbstractTNF receptor associated factor 6 (TRAF6) is an E3 ubiquitin ligase that has been implicated in myeloid malignancies. Although altered TRAF6 expression is observed in human acute myeloid leukemia (AML), its role in the AML pathogenesis remains elusive. In this study, we showed that the loss of TRAF6 in AML cells significantly impairs leukemic function in vitro and in vivo, indicating its functional importance in AML subsets. Loss of TRAF6 induces metabolic alterations, such as changes in glycolysis, TCA cycle, and nucleic acid metabolism as well as impaired mitochondrial membrane potential and respiratory capacity. In leukemic cells, TRAF6 expression shows a positive correlation with the expression of O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT), which catalyzes the addition of O-GlcNAc to target proteins involved in metabolic regulation. The restoration of growth capacity and metabolic activity in leukemic cells with TRAF6 loss, achieved through either forced expression of OGT or pharmacological inhibition of O-GlcNAcase (OGA) that removes O-GlcNAc, indicates the significant role of O-GlcNAc modification in the TRAF6-related cellular and metabolic dynamics. Our findings highlight the oncogenic function of TRAF6 in leukemia and illuminate the novel TRAF6/OGT/O-GlcNAc axis as a potential regulator of metabolic reprogramming in leukemogenesis.
Mechanically triggered on-demand degradation of polymers synthesized by radical polymerizations
Authors: Liu Peng , Jimaja Sètuhn , Immel Stefan , Thomas Christoph , Mayer Michael , Weder Christoph , Bruns Nico 
Published: April 2024

AbstractPolymers that degrade on demand have the potential to facilitate chemical recycling, reduce environmental pollution and are useful in implant immolation, drug delivery or as adhesives that debond on demand. However, polymers made by radical polymerization, which feature all carbon-bond backbones and constitute the most important class of polymers, have proven difficult to render degradable. Here we report cyclobutene-based monomers that can be co-polymerized with conventional monomers and impart the resulting polymers with mechanically triggered degradability. The cyclobutene residues act as mechanophores and can undergo a mechanically triggered ring-opening reaction, which causes a rearrangement that renders the polymer chains cleavable by hydrolysis under basic conditions. These cyclobutene-based monomers are broadly applicable in free radical and controlled radical polymerizations, introduce functional groups into the backbone of polymers and allow the mechanically gated degradation of high-molecular-weight materials or cross-linked polymer networks into low-molecular-weight species.
Cataract-1K Dataset for Deep-Learning-Assisted Analysis of Cataract Surgery Videos
Authors: Ghamsarian Negin , El-Shabrawi Yosuf , Nasirihaghighi Sahar , Putzgruber-Adamitsch Doris , Zinkernagel Martin , Wolf Sebastian , Schoeffmann Klaus , Sznitman Raphael 
Published: April 2024

AbstractIn recent years, the landscape of computer-assisted interventions and post-operative surgical video analysis has been dramatically reshaped by deep-learning techniques, resulting in significant advancements in surgeons’ skills, operation room management, and overall surgical outcomes. However, the progression of deep-learning-powered surgical technologies is profoundly reliant on large-scale datasets and annotations. In particular, surgical scene understanding and phase recognition stand as pivotal pillars within the realm of computer-assisted surgery and post-operative assessment of cataract surgery videos. In this context, we present the largest cataract surgery video dataset that addresses diverse requisites for constructing computerized surgical workflow analysis and detecting post-operative irregularities in cataract surgery. We validate the quality of annotations by benchmarking the performance of several state-of-the-art neural network architectures for phase recognition and surgical scene segmentation. Besides, we initiate the research on domain adaptation for instrument segmentation in cataract surgery by evaluating cross-domain instrument segmentation performance in cataract surgery videos. The dataset and annotations are publicly available in Synapse.
An efficient polynomial-based verifiable computation scheme on multi-source outsourced data
Authors: Zhang Yiran , Geng Huizheng , Su Li , He Shen , Lu Li 
Published: April 2024

AbstractWith the development of cloud computing, users are more inclined to outsource complex computing tasks to cloud servers with strong computing capacity, and the cloud returns the final calculation results. However, the cloud is not completely trustworthy, which may leak the data of user and even return incorrect calculations on purpose. Therefore, it is important to verify the results of computing tasks without revealing the privacy of the users. Among all the computing tasks, the polynomial calculation is widely used in information security, linear algebra, signal processing and other fields. Most existing polynomial-based verifiable computation schemes require that the input of the polynomial function must come from a single data source, which means that the data must be signed by a single user. However, the input of the polynomial may come from multiple users in the practical application. In order to solve this problem, the researchers have proposed some schemes for multi-source outsourced data, but these schemes have the common problem of low efficiency. To improve the efficiency, this paper proposes an efficient polynomial-based verifiable computation scheme on multi-source outsourced data. We optimize the polynomials using Horner’s method to increase the speed of verification, in which the addition gate and the multiplication gate can be interleaved to represent the polynomial function. In order to adapt to this structure, we design the corresponding homomorphic verification tag, so that the input of the polynomial can come from multiple data sources. We prove the correctness and rationality of the scheme, and carry out numerical analysis and evaluation research to verify the efficiency of the scheme. The experimental indicate that data contributors can sign 1000 new data in merely 2 s, while the verification of a delegated polynomial function with a power of 100 requires only 18 ms. These results confirm that the proposed scheme is better than the existing scheme.
Harnessing spin and orbital angular momentum light for optimal algae growth
Authors: He Yancong , Huang Ziling , Zeng Qiongfang , Huang Huihui 
Published: April 2024

AbstractThe present study investigated the difference in transmittance of light carrying opposite spin angular momentum (SAM) and orbital angular momentum (OAM) through chlorella algal fluid with varying concentrations and thicknesses. Our results indicate that, under specific conditions, right-handed light sources exhibit higher transmittance in the algal fluid compared to left-handed light sources. Furthermore, we observed that light with OAM also demonstrated higher transmittance than other types of light sources, leading to faster cell density growth of Chlorella. Interestingly, we also discovered that light with OAM stimulates Chlorella to synthesize more proteins. These findings provide different insights for selecting appropriate light sources for large-scale algae cultivation, and may facilitate the realization of carbon peaking and carbon neutrality in the future.
Endosymbiont diversity across native and invasive brown widow spider populations
Authors: Mowery Monica A. , Rosenwald Laura C. , Chapman Eric , Lubin Yael , Segoli Michal , Khoza Thembile , Lyle Robin , White Jennifer A. 
Published: April 2024

AbstractThe invasive brown widow spider, Latrodectus geometricus (Araneae: Theridiidae), has spread in multiple locations around the world and, along with it, brought associated organisms such as endosymbionts. We investigated endosymbiont diversity and prevalence across putative native and invasive populations of this spider, predicting lower endosymbiont diversity across the invasive range compared to the native range. First, we characterized the microbial community in the putative native (South Africa) and invasive (Israel and the United States) ranges via high throughput 16S sequencing of 103 adult females. All specimens were dominated by reads from only 1–3 amplicon sequence variants (ASV), and most individuals were infected with an apparently uniform strain of Rhabdochlamydia. We also found Rhabdochlamydia in spider eggs, indicating that it is a maternally-inherited endosymbiont. Relatively few other ASV were detected, but included two variant Rhabdochlamydia strains and several Wolbachia, Spiroplasma and Enterobacteriaceae strains. We then diagnostically screened 118 adult female spiders from native and invasive populations specifically for Rhabdochlamydia and Wolbachia. We found Rhabdochlamydia in 86% of individuals and represented in all populations, which suggests that it is a consistent and potentially important associate of L. geometricus. Wolbachia was found at lower overall prevalence (14%) and was represented in all countries, but not all populations. In addition, we found evidence for geographic variation in endosymbiont prevalence: spiders from Israel were more likely to carry Rhabdochlamydia than those from the US and South Africa, and Wolbachia was geographically clustered in both Israel and South Africa. Characterizing endosymbiont prevalence and diversity is a first step in understanding their function inside the host and may shed light on the process of spread and population variability in cosmopolitan invasive species.
Phosphoglycerate mutase 5 exacerbates liver ischemia–reperfusion injury by activating mitochondrial fission
Authors: Tang Hongwei , Yu Qiwen , Chen Xu , Zhang Jiakai , Guo Danfeng , Guo Wenzhi , Zhang Shuijun , Shi Xiaoyi 
Published: April 2024

AbstractAlthough the death of hepatocytes is a crucial trigger of liver ischemia–reperfusion (I/R) injury, the regulation of liver I/R-induced hepatocyte death is still poorly understood. Phosphoglycerate mutase 5 (PGAM5), a mitochondrial Serine/Threonine protein phosphatase, regulates mitochondrial dynamics and is involved in the process of both apoptosis and necrotic. However, it is still unclear what role PGAM5 plays in the death of hepatocytes induced by I/R. Using a PGAM5-silence mice model, we investigated the role of PGAM5 in liver I/R injury and its relevant molecular mechanisms. Our data showed that PGAM5 was highly expressed in mice with liver I/R injury. Silence of PGAM5 could decrease I/R-induced hepatocyte death in mice. In subcellular levels, the silence of PGAM5 could restore mitochondrial membrane potential, increase mitochondrial DNA copy number and transcription levels, inhibit ROS generation, and prevent I/R-induced opening of abnormal mPTP. As for the molecular mechanisms, we indicated that the silence of PGAM5 could inhibit Drp1(S616) phosphorylation, leading to a partial reduction of mitochondrial fission. In addition, Mdivi-1 could inhibit mitochondrial fission, decrease hepatocyte death, and attenuate liver I/R injury in mice. In conclusion, our data reveal the molecular mechanism of PGAM5 in driving hepatocyte death through activating mitochondrial fission in liver I/R injury.
Comparable long‑term survival outcomes of endoscopic treatment versus surgical treatment for gastrointestinal stromal tumors with a diameter of 5–10 cm
Authors: Liu Zide , Tao Qing , Wu Yonghui , Zeng Chunyan , Chen Youxiang 
Published: April 2024

AbstractCurrently, endoscopic treatment for small gastrointestinal stromal tumors (GIST) has been widely accepted. However, for tumors larger than 5 cm, endoscopic treatment has not been recognized by national guidelines as the standard therapy due to concerns about safety and adverse tumor outcomes. Therefore, this study compares the long-term survival outcomes of endoscopic treatment and surgical treatment for GIST in the range of 5–10 cm. We selected patients with GIST from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2015. Kaplan–Meier analysis and the log-rank test were employed to compare the long-term survival outcomes between endoscopic treatment and surgical treatment. A multivariate Cox proportional hazards model was used for analysis to identify risk factors influencing patient prognosis. To balance baseline data, we performed 1:1 propensity score matching (PSM). A total of 1223 GIST patients were included, with 144 patients (11.8%) received endoscopic treatment and 1079 patients (88.2%) received surgical treatment. Before PSM, there was no significant difference in the long-term survival rates between the two groups [5-year OS (86.5% vs. 83.5%, P = 0.42), 10-year OS (70.4% vs. 66.7%, P = 0.42)]. After adjusting for covariates, we found that the overall survival (HR = 1.26, 95% CI 0.89–1.77, P = 0.19) and cancer-specific survival (HR = 1.69, 95% CI 0.99–2.89, P = 0.053) risks were comparable between the endoscopic treatment group and the surgical treatment group. In the analysis after PSM, there was no significant difference between the endoscopic treatment group and the surgical treatment group. Our study found that for GIST patients with tumor sizes between 5 and 10 cm, the long-term OS and CSS outcomes were similar between the endoscopic treatment group and the surgical treatment group.