bluuebunny/crossref_metadata_2025_split huggingface dataset:
X‐ray diffraction studies of the tophaceous deposits in gout
Authors: Howell R. Rodney , Eanes Edward D. , Seegmiller J. E. 
Published: February 2007

AbstractThe form of the uric acid present in the crystalline material of subcutaneous tophi in two gouty patients has been positively characterized as monosodium urate monohydrate by using x‐ray diffraction technics, while a urinary calculus was shown to contain free uric acid. The x‐ray diffraction powder patterns and d line values for the reference compounds uric acid, monosodium urate monohydrate, and disodium urate dihydrate are also presented.
The rheumatoid factor activity of dextran eluates of erythrocytes and platelets
Authors: Hunder Gene G. , Vaughan John H. , Jacox Ralph F. 
Published: February 2007

AbstractA material which can cause agglutination of latex particles can be eluted by dextran from erythrocytes and platelets obtained from normal humans, from patients with non‐rheumatoid diseases, and from rabbit erythrocytes. A report by others had suggested that such an eluate was a rheumatoid factor. The lack of disease specificity suggests that this agglutinating substance may differ from rheumatoid factor. A substance eluted from platelets by dextran appears to be rheumatoid factor.
Interaction of gold and penicillamine
Authors: Eyring Edward J. , Engleman Ephraim P. 
Published: February 2007

AbstractIn order to evaluate penicillamine as an agent for treatment of toxicity to gold, a laboratory and clinical experimental study has been carried out. In vitro studies show that the compound has great affinity for ionic gold (K1·K2 = 24.8). In vivo, the drug competes successfully with rat tissue for simultaneously administered gold and prevents deposition of gold in tissues, especially the kidney. Finally, in acute experiments, penicillamine has been found to enhance human urinary excretion of gold.
Ancient therapeutic arts in the gout
Authors: Rodnan Gerald P. , Benedek Thomas G. 
Published: February 2007

AbstractThis is an illustrated account of the early measures employed in the treatment of gout, comprising magical and religious cures and various forms of counter‐irritation, including cautery, moxibustion, acupuncture, setons and issues, as well as blood‐letting and galvanism. Certain of these latter practices, founded on the ancient humoral theory of disease, continue to be used in their orginal form to the present day while others have served as the foundation for some current methods of physical therapy.
The arthritis of Whipple's disease
Authors: Kelly John J. , Weisiger Benjamin B. 
Published: February 2007

AbstractDespite the well appreciated fact that arthropathy frequently occurs with Whipple's disease, this is often not considered in dealing with obscure joint problems. A review of 95 cases with typical histologic changes of Whipple's disease revealed arthropathy in 64. This usually consisted of an acute, intermittent and often migratory polyarthritis which was followed by periods of complete remission. Spondylitis, both with and without sacro‐iliac fusion, was less commonly observed.
Latex fixation test in rheumatoid arthritis III. A longitudinal study of the titer of rheumatoid factor and thermolabile inhibitor
Authors: Schubart Adalbert F. , Cohen Alan S. , Calkins Evan 
Published: February 2007

AbstractIn the latex fixation test the determination of the titer of rheumatoid factor together with the thermolabile inhibitor was shown to provide reproducible serological parameters which were used in a longitudinal study of 66 patients with rheumatoid arthritis. All 8 patients who experienced an unequivocal remission during the course of observation were found in the group of patients with relatively low titers of the latex fixation test and with varying degrees of thermolabile inhibition. No remissions occurred in the group of patients with high titers with out thermolabile inhibition.
Acromegalic arthropathy. A case report
Authors: Good Armin E. 
Published: February 2007

AbstractA case history of a patient with an eosinophilic pituitary adenoma is presented, in which joint symptoms dominated much of the course. The diagnosis of acromegaly was made 13 years after an initial, erroneous diagnosis of rheumatoid arthritis. The end result in this case has been severely disabling hypertrophic disease of the hip joints.
Studying the epidemiology of rheumatoid arthritis in Israel: Methodological considerations
Authors: Abramson J. H. , Adler E. , Hader S. Ben , Elkan Zipora , Gabriel K. R. , Wahl Miriam 
Published: February 2007

AbstractThe outline of the epidemiological study of rheumatoid arthritis in the Western region of Jerusalem (population about 14,000, interview sample about 8,000, examination sample about 2,000), is given. The semantic difficulties, reliability of diagnostic criteria, evaluation of x‐ray pictures, validity of Rh. A. index with regard to cultural, social and ethnical background, and its special significance within the population of Israel, influence of non‐response to interview and/or examination on statistical results, and repeated examinations of a part of the sample in a remittant chronic disease like rheumatoid arthritis, are discussed. The relatively large number of the sample in this present study may render possible to overcome the many pitfalls involved.
Experimentally induced arthritis using intra‐articular papain
Authors: Murray David G. 
Published: February 2007

AbstractDaily injection of a crude papain solution into the knee joint of young rabbits continued over a six day period resulted in a degeneration of the articular cartilage within two weeks. The initial findings were elevation and loosening of the cartilage in the weight bearing area followed by thinning and fibrillation of the remaining surface. Microscopic changes consisted of disruption of the cartilage adjacent to the subchondral bone and loss of the superficial layers. Changes in the articular cartilage were similar to changes seen in clinical forms of degenerative arthritis.
Relationships between genitourinary infection and complicating arthritis
Authors: Ford Denys K. , Rasmussen George 
Published: February 2007

AbstractSixty‐nine episodes of arthritis associated with urethritis or cystitis were studied in 58 heterosexual Caucasian males and 7 episodes in 2 North American Indians, the observations being made in Vancouver, British Columbia. The arthritis following gonorrhea was similar to that following non‐gonococcal urethritis and in both groups extramarital venereal exposure was the usual initiating event. No evidence could be found that mycoplasmal or viral agents were responsible for the arthritis.
Polymyositis and aplastic anemia a report of a case
Authors: Healey L. A. , Pearson Carl M. , Engleman Ephraim P. , Engleman Ephraim P. , Gardner Frank H. 
Published: February 2007

AbstractThe appearance of aplastic anemia in a seventy‐one year old man with polymyositis is described. The pancytopenia was unrelated to drugs and was fatal. Autopsy confirmed both diagnoses and disclosed no occult neoplasm. Although its association with visceral malignancy is well known, the occurence of polymyositis and aplastic anemia in the same patient has been reported but once before.
An isohemagglutinin deficiency in relatives of rheumatoid patients
Authors: Rawson Arnold J. , Abelson Neva M. 
Published: February 2007

AbstractPatients with rheumatoid arthritis belonging to blood group 0 have deficient activity of anti‐A and anti‐B isohemagglutinins in chromatographic fractions containing γss, γ1A and γ1M globulins. Asymptomatic close relatives of these patients, if they too belong to blood group 0 have deficient isohemagglutinin activity only in an intermediate fraction containing y1A and yss globulins. Evidence is presented which suggests that the latter deficiency is attributable to the γ1A globulin, and is not the result of complexing with rheumatoid factor.
Patients' attitudes and knowledge concerning arthritis
Authors: Edwards Margaret H. , Calabro John J. , Wied Marion E. 
Published: February 2007

AbstractA 27‐item questionnaire dealing with attitudes and information concerning arthritis was administered to 100 patients attending an arthritis out‐patient clinic, and responses were compared with information obtained from their physicians. Several discrepancies between patients' and physicians' concepts of clinical status and therapy were apparent, as well as differences in attitudes and beliefs related to factors of age, education, and type of arthritis. One‐hundred and eighty forms of treatment had been recommended to the patients by non‐professional persons.
Erythrocyte survival in rheumatoid arthritis
Authors: Mongan Edward S. , Jacox Ralph F. 
Published: February 2007

AbstractThirty patients with active rheumatoid arthritis were transfused with chromium‐51 labeled erythrocytes from either normal or rheumatoid donors. Three sets of identical twins discordant for rheumatoid arthritis had a cross transfusion from a healthy donor to the affected recipient. In no instance was there any significant shortening of erythrocyte survival which could not be attributed to minor blood group incompatibility. The presence of rheumatoid factor in either the donor, the recipient, or both did not effect erythrocyte survival.
Lactic dehydrogenase (LDH) and transaminase (GOT) activity of synovial fluid and serum in rheumatic disease states, with a note on synovial fluid LDH isozymes
Authors: Cohen Alan S. 
Published: February 2007

AbstractLactic acid dehydrogenase (LDH) and glutamic‐oxalacetic transaminase determinations were carried out on the serums and synovial fluids of patients with a variety of rheumatic diseases. The LDH activity of the synovial fluid was elevated in patients with rheumatoid degenerative joint disease. Transaminase activity was normal in both serum and synovial fluid in all cases. Starch gel zymograms of LDH showed qualitatively increased amounts of the isozyme LDH 5 in the pathological synovial fluids.
Studies on adjuvant‐induced polyarthritis in rats. III. The effect of “immunosuppressive agents” on arthritis and tuberculin hypersensitivity
Authors: Ward John R. , Clovd R. Sidney , Krawitt Edward L. , Jones Russell S. 
Published: February 2007

AbstractMethotrexate, 6‐mercaptopurine and total body x‐irradiation, given to rats injected with mycobacterial adjuvant, suppressed the development of polyarthritis without altering hypersensitivity to old tuberculin. Mechlorethamine hydrochloride was without effect. This dissociation of arthritis and tuberculin hypersensitivity suggests that sensitization to tuberculoprotein plays no direct role in producing the arthritis. Methotrexate and 6‐mercaptopurine also suppressed the early inflammation at the site of adjuvant injection indicating an antiinflammatory action which is independent of their effects on immunologic mechanisms.
Osmotic pressure gradients and joint effusions
Authors: Lipson Richard L. , Baldes Edward J. , Anderson Joseph A. , Polley Howard F. 
Published: February 2007

AbstractThis study reveals that in rheumatoid joint disease the total osmotic pressure of synovial fluid tends to be lower than, or equal to, that of plasma. With local articular or general systemic improvement the total osmotic pressures of synovial fluid and plasma tend to increase, and that of synovial fluid may exceed that of plasma. The colloid osmotic pressure of synovial fluid from joints of patients with rheumatoid arthritis was lower than that of plasma.
A study of rheumatoid factor titers in patients receiving plasma and gamma globulin
Authors: Waller Marion , Mullinax Franklin , Toone Elam C. , Thurman Lee 
Published: February 2007

AbstractRheumatoid factor activity in four patients was not inhibited by infusions of large volumes of plasma and gamma globulin as measured by the Hyland latex, SHC, and SSC tests. There were also no demonstrable changes in the erythrocyte sedimentation rates, total serum proteins, electrophoretic patterns, and ultracentrifuge patterns. In vitro estimations showed that very large amounts of gamma globulin would be needed to achieve in vivo inhibition of rheumatoid factor activity.
The effect of hydralazine (apresoline) on collagen synthesis in carrageenin granulomas
Authors: Meilman Edward , Urivetsky Morton , Rapoport Claire 
Published: February 2007

AbstractHydralazine causes an increase in the various collagen fractions, neutral‐salt, acid, and insoluble in carrageenin granulomas in guinea pigs. It is of interest that hydralazine, diphenyl hydantoin and isonicotinic acid hydrazide, all of which may be associated with SLE are capable of stimulating collagen formation.
The progressive nature of gout with inadequate therapy
Authors: Lipson Richard L. , Slocumb Charles H. 
Published: February 2007

AbstractInadequate therapy does not stop the progression of gout. A case report is presented to emphasize the progressive nature of gout and importance of adequate therapy if progression is to be prevented. The patient described developed gout at an early age and progressed through the entire spectrum of uncontrolled gouty arthritis while receiving treatment for his condition. In addition, the patient illustrates the unusual complication of sacroiliac joint involvement demonstrated by x‐ray and biopsy.
Total hemolytic complement (CH50) and second component of complement (C′2hu) activity in serum and synovial fluid
Authors: Fostiropoulos George , Austen K. Frank , Bloch Kurt J. 
Published: February 2007

AbstractThe presence of the second component of human complement in synovial fluid was demonstrated by a stoichiometric titration using EAC′lagp4gp cells; fourth component and a moiety of third component were identified by immunoelectrophoresis using specific antiserum. The concentration of total hemolytic complement, C′2, and C′4 was strikingly diminished in synovial fluid from patients with rheumatoid arthritis compared to their concentration in synovial fluid from patients with traumatic, degenerative or gouty effusions. These findings suggest that reduction in total complement activity was due to activation of C′1 with subsequent utilization of its substrates, C′2 and C′4.
Rheumatoid arthritis and constrictive pericarditis a patient benefited by pericardectomy
Authors: Lange Richard K. , Weiss Thomas E. , Ochsner John L. 
Published: February 2007

AbstractRheumatoid arthritis is a systemic disease involving, in addition to joints, many organs in variable degrees. A case is presented of early rheumatoid arthritis complicated by constrictive pericarditis necessitating pericardectomy. This case is presented to emphasize a potential problem of cardiac involvement in evaluating the condition of a patient with rheumatoid disease and because few cases have been reported requiring surgical treatment.
The effects of intra‐articular thiotepa on synovial fluids
Authors: Howes Ronald G. , Jarvis Basil 
Published: February 2007

AbstractStudy of the synovial fluids of nine patients suffering from rheumatoid arthritis before and four weeks after the injection of thiotepa, showed a significant drop in the total white cell count, a reversion to a more normal differential count and significant reduction in the synovial fluid/serum protein ratio, total proteins and gammaglobulin levels.
Treatment of primary gout: The present status (The W. Paul Holbrook Memorial Lecture)
Authors: Gutman Alexander B. 
Published: February 2007

AbstractThe following article was delivered by Dr. Gutman as the W. Paul Holbrook Memorial Lecture at the annual meeting of the Arthritis and Rheumatism Association, in June, 1965, a variation in lay terms having been presented at the annual meeting of The Arthritis Foundation in October, 1964. It is one of two memorial lectureships established by The Arthritis Foundation to honor physicians who have made outstanding contributions to the field of rheumatology with the objective, as well, of encouraging interest among all physicians and scientists in the field of rheumatic diseases. The other lecture, in honor of Walter Bauer, was delivered by Halstead R. Holman at the interim meeting of the ARA in December, 1964. The lectureship awards are part of the National Scientific Awards Program of The Arthritis Foundation.
The osteoporosis of rheumatoid arthritis
Authors: Duncan Howard , Frost Harold M. , Villanueva Antonio R. , Sigler John W. 
Published: February 2007

AbstractA metabolic bone disturbance has been demonstrated in all of seven patients with classical rheumatoid arthritis of six months to twenty years duration. All patients were receiving salicylate therapy alone while two had received corticosteroids four years before this study. A new quantitative and qualitative histological study of the cytodynamics of bone was used. The evidence suggests that an active diffuse demineralization was present in all patients, and was related directly to the disease process itself or to its therapy.
Hyperuricemia, acute gout, renal insufficiency and urate nephrolithiasis due to starvation
Authors: Drenick Ernst J. 
Published: February 2007

AbstractThe levels of uric acid in the serum and the excretion in the urine was measured in a group of 43 obese individuals who starved for prolonged periods and were then fed low calorie diets. Many obese patients were noted to have abnormally high serum uric acid levels initially. With starvation, marked hyperuricemia occurred due to impaired renal clearance. Four patients developed gout. Renal clearance was improved with the administration of probenecid and gout did not occur in the treated patients. The sudden excretion of large amounts of uric acid when hyperuricemic patients were given probenecid led to the development of uric acid calculi in one subject. Feeding of protein or carbohydrate resulted in a reduction of starvation ketosis and serum uric acid levels while improving renal uric acid clearance.
The nature of phospholipids in normal and rachitic costochondral plates
Authors: Howell David S. , Marquez Juan F. , Pita Julio C. 
Published: February 2007

AbstractInterest in fundamental biochemical processes of mineralization in osteoid led to a study of rachitic calf costal junctions in respect to a profile of phospholipids. Currently, chloroformmethanol extracts of rachitic and normal costochondral junctions were applied to thin‐layer silica gel chromatograms, and the phospholipids thereby separated were quantitated in terms of phosphorus content of the eluted spots. Striking differences between normal and rachitic tissues were found in respect to this profile of phospholipids.
Psychological factors in juvenile rheumatoid arthritis
Authors: Cleveland Sidney E. , Rezitman E. Edward , Brewer Earl J. 
Published: February 2007

AbstractThe results of this study offer hypotheses concerning the interplay of psychological factors and chronic somatic illness. Leads for further research include examination of the psychological effects of prolonged immobilization and the differential response of arthritic children to immobilization. Another avenue for study involved the attitudes of the children and their families to chronic illness and the relationship of these attitudes to treatment response. These and other leads emerging from this pilot study will now be pursued in a larger and more systematic research program employing an appropriate control group.
The Distribution of Rheumatoid Factor and Rheumatoid Arthritis in the Families of Blackfeet and Pima Indians
Authors: Bennett P. H. , Burch T. A. 
Published: February 2007

AbstractAn analysis of the distribution of RF and RA among the families of the Pima and Blackfeet Indians has shown evidence of familial aggregation of positive bentonite flocculation tests and RA within a single generation in the Pima tribe. No evidence could be found that these characteristics were determined by hereditary factors. The data suggest that RF (BFT) and possibly RA were determined by environmental factors in the Pima Indians, but no direct evidence of this could be found in the Blackfeet tribe. It is postulated that RF and RA may be determined by environmental factors operating maximally during the period of infancy, childhood or adolescence.
Skeletal muscle involvement in progressive systemic sclerosis (scleroderma)
Authors: Medsger Thomas A. , Rodnan Gerald P. , Moossy John , Vester John W. 
Published: February 2007

Abstract53 patients with typical PSS were examined for evidence of muscle weakness, abnormal serum enzymes, disturbances in urinary creatine and creatinine, and histopathologic alterations in skeletal muscle tissue. The majority was found to have clinical and biochemical features of primary myopathy. Microscopic involvement of muscle fibers or interstitium was present in 14 of 36 cases; the most consistent abnormality was interstitial fibrosis. This muscle involvement is considered an important feature in the course of PSS.
Infected synovial cysts arising as a complication of septic arthritis in a patient with rheumatoid arthritis
Authors: Hall Anthony P. , Healey L. A. 
Published: February 2007

AbstractAn elderly man with rheumatoid arthritis developed a streptococcal septicemia and arthritis following excision of an elbow nodule. His left calf became swollen; thrombophlebitis was initially diagnosed, but pus was aspirated from the calf and elbow and arthrograms showed large synovial cysts in both locations. The importance of aspirating any unusual calf swelling is emphasized.
Bertram M. Gesner, 1931–1968
Authors: Weissmann Gerald , Franklin Edward C. , Uhr Jonathan W. 
Published: February 2007

Abstract‘Medicine does not end in hospitals, as is often believed, but merely begins there. In leaving the hospital, a physician, jealous of his title in its scientific sense, must go into the laboratory; and there by experiments on animals he will seek to account for what he has observed in his patient. There, in a word, he will achieve true medical science.”—Claude Bernard, 1865
The Glycosaminoglycans of the Human Joint Capsule: Isolation and Characterization
Authors: Heinegård D. , Hernborg J. , Lundberg B. J. 
Published: February 2007

AbstractIn human osteoarthritic knee joint capsules the total concentration of hexosamine and the concentration as hexosamine of the glycosaminoglycans was found to be 1.1 per cent and 0.2 per cent of tissue dry weight respectively. The cetylpyridinium chloride fractionation pattern indicated no major differences in comparison with normal capsules. When identified on a small level the results correlated rather well with the macro‐level analysis. Hyaluronic acid, chondroitin‐6 sulfate and dermatan sulfate could be identified whereas keratan sulfate was a minor component in the capsular digest. Another minor component which could not be conclusively identified might be heparan sulfate. Data suggestive of DS‐CS hybrids were present.
Vasculitis of the Breasts
Authors: Mccarty Daniel J. , Imbrigia Joseph , Hung Jean K. 
Published: February 2007

AbstractA unique case of a 66‐year‐old white woman with multiple tender lumps in both breasts due to vasculitis has been presented. The features differentiating this case from giant cell arteritis and superficial thrombophlebitis of the chest wall (Mondor's Disease) are reviewed.
Resorption of the terminal phalanges in scleroderma
Authors: Scharer Lawrence , Smith Donald W. , Rodan Gerald P. , Holling H. Edward , Scharer Lawrece , Smith Donald W. 
Published: February 2007

AbstractA case of Raynaud's phenomenon and scleroderma in a 54‐year‐old woman is reported. One of the patient's fingers had been reattached surgically after being partially amputated in a childhood accident. When sensitivity to cold and scleroderma began in later life, this finger was not affected. The circulation in all fingers was impaired, and all but the “amputated” finger showed roentgenographic evidence of severe resorption of terminal phalangeal bone.