bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilateral renal angiomyolipoma
Authors: Toncaonkar H. B. , Sampat M. B. , Dalal A. V. , Dandekar N. P. , Kulkarni J. N. , Kamat M. R. 
Published: February 2007

AbstractBilateral renal angiomyolipoma is a rare entity, usually associated with tuberous sclerosis. Five cases of bilateral renal angiomyolipoma, all females, with a mean age of 34.6 years, are reported. All patients had symptoms attributable to lesions only on one side, with flank pain and mass the commonest symptoms encountered. Only one case had clinical evidence of stigmata of tuberous sclerosis. The mean size of the lesions on the symptomatic side was 17 cm, while that on the asymptomatic side was 2 cm. Three patients were diagnosed correctly as having angiomyolipomas preoperatively with the use of ultrasonography and computed tomography (CT); two of these were treated with total nephrectomy and the third with partial nephrectomy. The other two cases were seen before the availability of CT and were only diagnosed intraoperatively. Both patients were treated with total nephrectomy. The lesions on the asymptomatic side were kept on close surveillance. Two patients developed an increase in the size of the lesions in the contralateral kidney 1 year and 3 1/2 years after the first surgery. Both patients were treated with partial nephrectomy. All patients are alive at 3—14 years (mean 6.6 years) after operation. © 1994 Wiley‐Liss, Inc.
Can the hormonal receptor status of primary breast cancer be altered by neoadjuvant chemotherapy?
Authors: Lo Su‐Shun , Wang Hwei‐Chung , Shyr Yi‐Ming , Lui Wing‐Yiu 
Published: February 2007

AbstractIn order to know whether neoadjuvant chemotherapy would change the hormonal receptor status of primary breast cancer, 10 patients with locally advanced breast cancer treated with neoadjuvant CEF (endoxan, epirubicin, 5‐fluorouracil) were studied. Tissue was obtained by incisional biopsy before chemotherapy and by mastectomy after three courses of treatment. All the specimens were subjected to histology study and the tests of estrogen (ER) and progesterone (PgR) receptors. The results revealed that the only hormonal status of one out of 10 tumors was altered. Among the 10 tumors, 2 out of 10 ER and 3 out of 10 PgR were changed after neoadjuvant CEF. From our results together with others findings, it is concluded that neoadjuvant CEF dose not significantly change the hormonal receptor status of primary breast cancer. The hormonal receptor assay is unnecessary before chemotherapy. © 1994 Wiley‐Liss, Inc.
Anticancer chemosensitivity profile of freshly separated human pancreatic cancer cells assessed by DNA synthesis inhibition assay
Authors: Masai Yoshikazu , Nio Yoshinori , Tsubono Michihiko , Tseng Chen‐Chiu , Kawabata Kazuya , Hayashi Hitoshi , Ishigami Shunichi , Imamura Masayuki 
Published: February 2007

AbstractThe chemosensitivity of 49 freshly separated human pancreatic cancers to seven kinds of anticancer agents were assessed by a DNA synthesis (3H‐thymidine incorporation) inhibition assay. DNA synthesis is higher in involved lymph nodes (n=7), malignant effusion (n=15), liver metastasis (n=7), primary cancer (n=15), and skin metastasis (n=5). Chemosensitivity assay demonstrates that etoposide, 4‐epirubicin, carboquone, and 5‐fluorouracil are more effective than cisplatin, mitomycin‐C, and Adriamycin. In general, metastatic lesions of pancreatic cancer tend to show higher chemosensitivity than primary lesions. Pathological analysis demonstrates that small primary pancreatic cancers tend to be more responsive than large primary cancers, and primary pancreatic cancers with no regional lymph node involvement also tend to be more responsive than those with nodal involvement. No significant differences are seen in terms of tumor spread, vascular involvement, sex of patient, and histological type. When chemosensitivity assay is not available, the results of the present study may be beneficial to choose the regimens. © 1994 Wiley‐Liss, Inc.
Expression of desmoglein I in squamous cell carcinoma of the esophagus
Authors: Natsugoe Shoji , Aikou Takashi , Shimada Mario , Kumanohoso Toru , Tezuka Yoshihisa , Sagara Mitsuhisa , Yoshinaka Heiji , Baba Masamichi , Fukumoto Toshitaka 
Published: February 2007

AbstractDesmoglein I (DGI) is major component of the desmosomal membrane core that plays an important role in epithelial cell adhesion. The aim of this study was to explore the correlation between the expression of DGI and the clinicopathological findings of esophageal cancer. DGI expression was immunohistochemically examined using an anti‐DGI monoclonal antibody in 139 patients with squamous cell carcinoma of the esophagus. Normal squamous epithelial cells strongly expressed DGI at their cell‐cell boundaries. According to the intensity and pattern of DGI expression, the cancerous tissues were divided into three groups: DGI (++), DGI (+), and DGI (‐). Of the 139 tumors, 35 (25%) were DGI (++), 65 (47%) were DGI (+), and 39 (28%) were DGI (‐). A good inverse correlation between DGI expression and tumor invasion, lymph node metastasis, lymphatic invasion, and vessel invasion was observed. These results indicate that DGI expression may be a significant factor for invasion, metastasis, and prognosis of human esophageal cancer. © 1994 Wiley‐Liss, Inc.
Total abdominal perfusion (TAP) in the treatment of abdominal metastatic melanoma
Authors: Klein Ehud S. , Davidson Binyamin , Ben‐Ari Gur Y. , Apter Sara , Azizi Esther 
Published: February 2007

AbstractTotal abdominal perfusion (TAP) is a recently described technique in which the abdominal organs are isolated from the systemic circulation and perfused by means of an external pump. Administering chemotherapy into the circuit provides higher locoregional drug exposure with lower systemic toxicity. Two patients with melanoma metastatic to the abdomen were treated using this technique. The first patient suffered from intractable upper gastrointestinal bleeding due to unresectable melanoma metastasis of the duodenum. He underwent TAP with melphalan and cisplatinum. His bleeding stopped and the tumor regressed. This patient's response lasted for 6 months. The second patient had an unresectable liver metastasis. She underwent TAP with melphalan and DTIC, resulting in a complete response with disappearance of the liver mass, which lasted until her death in 13 months. Our conclusion is that TAP should be considered as a technique for regional chemotherapy, which may be used in the treatment of unresectable metastatic melanoma of the abdomen. © 1994 Wiley‐Liss, Inc.
Clinical outcome after neoadjuvant thermoradiotherapy in high grade soft tissue sarcomas
Authors: Scully Sean P. , Oleson James R. , Leopold Kenneth A. , Samulski Thaddeus V. , Dodge Richard , Harrelson John M. 
Published: February 2007

AbstractIn the treatment of soft tissue sarcomas, hypothermia has been demonstrated to enhance tumor necrosis from radiation therapy. The current study reports the clinical course of patients treated with this neoadjuvant therapy regimen. Forty‐four patients with deep, undisturbed, nonmetastatic, high grade soft tissue sarcomas completed a neoadjuvant treatment protocol with combined hyperthermia and radiation therapy followed by wide surgical resection. Negative surgical margins were obtained in 40 patients. There was one local recurrence, thus yielding a local control rate of 97.5%. All other failures were either through regional lymphatic spread or pulmonary metastasis. As a group, the patients at 36 months had a 72% overall and a 58% disease‐free survival. The most common pathologic diagnosis was malignant fibrous histiocytoma (MFH), which demonstrated a 36‐month survival of 52% vs. 82% for others (P=0.02). Tumor size was not prognostically significant for disease free or overall survival (P=0.13). Those patients with surgical margins <1 cm had a significantly lover disease‐free survival and overall survival in a multivariate analysis (P=0.02 andP=0.006, respectively). Overall survival did not correlate with either the number of hyperthermia treatments received or the amount of tumor necrosis. Although this neoadjuvant protocol results in excellent local control rates, overall survival rates are comparable to adjuvant therapy employing radiation alone. © 1994 Wiley‐Liss, inc.
Radiation induced sarcomas following treatment for breast cancer: Presentation of a series of 14 cases treated with an aggressive surgical approach
Authors: Rivoire M. , Delay E. , El Arini A. , Mignotte H. , Wagner P. , Zlatoff P. , Bobin J. Y. 
Published: February 2007

AbstractAccording to the criteria established by Cahan et al., we report 14 radiation induced sarcomas occurring in the treated volume after radiation therapy for adenocarcinoma of the breast. All these sarcomas were treated by wide surgical resection. In spite of a macroscopic free margin, only patients who underwent major amputation could hope to be cured. All the centrally located sarcomas recurred. © 1994 Wiley‐Liss, Inc.
Metachronous bladder tumors in patients with upper urinary tract transitional cell carcinoma
Authors: Mukamel Eliahu , Simon Dan , Servadio Ciro , Konichezky Myriam , Hadar Herzlia , Edelman Abraham 
Published: February 2007

AbstractSixty‐nine patients who underwent nephroureterectomy for upper urinary tract transitional cell carcinoma were included in the study. The following data were collected for each patient: grade and stage of renal/ureteral tumor, tumor location, timing of tumor appearance and recurrence in the bladder, grade and stage of each of the recurrent tumors, and number of recurrences. Follow‐up ranged between 2 and 15 years. Thirty‐three patients (47.8%) developed metachronous bladder tumors. The appearance of the bladder tumors was related to tumor grade and multifocality of the upper urinary tract TCC. Of the 33 patients, 19 had 1 tumor appearance in the bladder, 6 had 2 recurrences, and 8 had 3 recurrences. The 5‐year survival rate for patients with no subsequent bladder tumors was 57% compared to 22% for those who had subsequent tumors. It is concluded that the appearance of bladder tumors following nephroureterectomy characterizes a group of patients with biologically more active disease with unfavorable prognosis. © 1994 Wiley‐Liss, inc.
Clinicopathological study of primary malignant tumors of the lung: An analysis of 993 tumors resected at the Kanazawa university hospital between 1979‐1993
Authors: Nonomura Akitaka , Mizukami Yuji , Shimizu Junzo , Oda Makoto , Murakami Shinya , Watanabe Yoh , Kobayashi Takeshi , Kamimura Ryoichi , Takashima Tsutomu , Kitagawa Masanobu 
Published: February 2007

AbstractA retrospective study was conducted of 993 malignant tumors of the lung in 977 patients. The male‐female sex ratio was 2.6:1. The age distribution of the males did not differ from that of the females and the overall mean age was 64.3 ± 9.5 years (range, 13–85 years). Forty‐three percent of the patients were in their seventh decade. The location was peripheral in 81% of the tumors and central in 19%. Of the central tumors, 85% were squamous cell (epidermoid) carcinoma (SCC), while 58% of the peripheral tumors were adenocarcinoma (ADENO). In males, 49% of all tumors were SCC and 36% ADENO, while in females 76% were ADENO. The incidence of positive lymph node metastasis increased in parallel with the pT status in both central and peripheral carcinomas. However, it was noted that, of peripheral lung carcinomas, no SCC with a diameter of 15 mm or less had lymph node metastasis, whereas 18.9% of the ADENO of this size were positive for lymph node metastasis. These results indicate that lymph node metastasis can occur even in small‐sized peripheral ADENO less than 15 mm. Thus, early detection and surgery together with mediastinal lymph node dissection are necessary even for small‐sized tumors to improve the prognosis in patients with peripheral ADENO of the lung. © 1995 Wiley‐Liss, Inc.
Duodenal leiomyosarcoma
Authors: Fishbein T. , Carroll M. , Beazley R. M. 
Published: February 2007

AbstractTwo cases of duodenal leiomyosarcoma were encountered, both of which appeared benign by gross and histologic criteria. Both patients suffered recurrences with poor outcomes. We reviewed the literature and found four other such cases and examined the outcomes in the world literature with respect to tumor size and extent of surgical resection. Large size, limited resections, and local recurrence were associated with poor outcomes. A 6% rate of lymphatic metastases was found, and the bearing this has on the extent of resection is discussed. © 1995 Wiley‐Liss, Inc.
Aneuploidy of tumor cells in cases of gastric cancer with esophageal invasion: Another indicator of poor prognosis
Authors: Ikeguchi Masahide , Ohfuji Satoshi , Oka Atsuo , Tsujitani Shunichi , Maeta Michio , Kaibara Nobuaki 
Published: February 2007

AbstractThe prognosis of patients with gastric cancer with esophageal invasion is extremely poor. To evaluate factors related to this poor prognosis, we analyzed 200 patients with gastric cancer located in the upper third of the stomach. These patients underwent gastrectomy and were divided into two groups in terms of the presence (E[+] group; n=62) or absence (E[‐] group; n=138) of histological evidence of esophageal invasion. Even when apparently curative surgery was performed, the 5‐year survival rate of patients with E[+] gastric cancer (45.8%) was significantly lower than of patients with E[‐] gastric cancer (71.6%). In the E[+] group, the 5‐year survival rate of patients who had tumors with infiltrative growth and DNA aneuploidy was only 10.0%. These patients had a high frequency of peritoneal metastasis at operation (5/16; 31.3%); even when apparently curative operations were performed, 50% of these patients died from peritoneal metastatic recurrence within 2 years after surgery. Gastric adenocarcinoma with esophageal invasion accompanied by infiltrative growth and DNA aneuploidy had a high potential for peritoneal metastasis. This combination is associated with the most pessimistic prognosis for patients with gastric cancer with esophageal invasion. © 1995 Wiley‐Liss, Inc.
Effect of dibutyryl cyclic AMP on the cell cycle of human pancreatic cancer inoculated in nude mice
Authors: Umezawa A. , Koyama K. , Tanaka J. , Sato Y. , Asanuma Y. 
Published: February 2007

AbstractThe prognosis of pancreatic cancer is very poor because of its high malignant potential. To improve the prognosis of pancreatic cancer, a decrease in the grade of maligancy by dibutyryl cyclic AMP (db‐cAMP), a differentiation inducer, was attempted using human pancreatic cancer cell line inoculated to nude mice.In this study, 0.1 or 5.0 μmol/animal/day of db‐cAMP was administered for 7 consecutive days in short‐term group animals and for 28 consecutive days in long‐term group animals. Animals in both groups are sacrificed 28 days after first administration of db‐cAMP, and tumor size, histology, and cell cycle analysis using flow cytometry (FCM) were studied.Tumor size and histology showed no significant changes by db‐cAMP. However, in cell cycle analysis, 5.0 μmol/animal/day of db‐cAMP brought significant block of the cell cycle phases between G1 and S in the short‐term group and the phase between S and G2/M in the long‐term group, indicating a decrease in cell cycle speed and, consequently, a decrease in the proliferation of tumor cell.The results show that db‐cAMP may be useful in decreasing the grade of malignancy of pancreatic cancer. © 1995 Wiley‐Liss, Inc.
Surgical management of adrenal metastasis from bronchogenic carcinoma
Authors: Ayabe Hiroyoshi , Tsuji Hiroharu , Hara Shinsuke , Tagawa Yutaka , Kawahara Katsunobu , Tomita Masao 
Published: February 2007

AbstractSurgical treatment for metastatic lesions from lung cancer is seldom performed. We have treated three patients with a unilateral adrenal metastasis with adrenalectomy. Simultaneous resection of primary lung cancer and adrenal metastasis was performed in two cases. This is the first report of such surgical management. Adrenalectomy after lung resection was done in the third case. Two of the patients are alive and well more than 5 years after adrenalectomy. These cases are presented, and the literature is reviewed. © 1995 Wiley‐Liss, Inc.
A national quality improvement effort: Cancer registry data
Authors: Kamell Lucy , Hoyler Suzanna S. , Seiffert Jennifer E. , Young John L. , Henson Donald E. , Winchester David P. , Osteen Robert T. , Clive Rosemarie E. , Ocwieja Kathleen M. , Menck Herman R. , Fremgen Amy 
Published: February 2007

AbstractCancer registries are sources of epidemiological, patterns‐of‐care, and outcome data for local, regional, state, and national studies of patients with cancer. Since 1976, these registries have formed a voluntary network of contributors to annual patient care studies under the aegis of the National Cancer Data Committee of the Commission on Cancer. These annual studies provide timely clinical information that is widely disseminated to physicians, allied health personnel, administrators, health care planners, and public and private agencies. The use of the data has grown exponentially and has been the basis for more than 90 publications. Merging this activity with the National Cancer Data Base has further expanded the demand and use of registry data. This study was undertaken to respond to inquiries as to the validity of the data and the qualifications and competency of cancer registrars. It provides the baseline for cancer registry data quality and serves as a quality management tool to identify opportunities to enhance data quality. © 1995 Wiley‐Liss, Inc.
Mucinous carcinoma of the breast: A pathologic study of 82 cases
Authors: André Saudade , Cunha Fernando , Soares Jorge , Bernardo Mário , E Sousa J. Meneses , Cortez Fernando 
Published: February 2007

AbstractA series of 82 consecutive cases of mucinous carcinomas of the female breast was investigated for their clinical, morphological, and histochemical features and for the influence of some tumor characteristics on its prognosis. Two groups, a “pure” subtype (n=58) and a “mixed” subtype (n=24), were considered, according to the absence or the presence of concomitant areas with typical infiltrating ductal carcinoma. Eighty patients were followed with an average of 7.4 years. The actuarial survival was 58.5% at 10 years. The group of pure mucinous carcinomas showed a statistically significant better prognosis (P=0.0007) than that of the group of mixed tumors, as well as a lower percentage of axillary nodal metastasis. Tumor dimension of both pure and mixed mucinous carcinomas influenced the prognosis, since patients with T1 tumors had longer survival than those with T2 tumors (P=0.05) and the latter showed less mortality than T3 tumor cases (P=0.036). Node‐negative patients also had a more favorable outcome with lower mortality than node positive patients (P=0.007). None of the T1 pure mucinous carcinomas had axillary metastasis, which may have implications for the surgical protocols. The evaluation of quantitative and qualitative content in mucosubstances did not correlate with the prognosis. However, sulfomucins were demonstrated in 30.5% of cases; this fact points to add breast carcinoma to the group of neoplasms that may present as a metastatic sulfomucin‐producing adenocarcinoma. © 1995 Wiley‐Liss, Inc.
Significance of estrogen receptors and cathepsin D tissue detection in gastric adenocarcinoma
Authors: Theodoropoulos George E. , Panoussopoulos Dimitris , Golematis Basil Ch. , Lazaris Andreas Ch. , Davaris Panagiotis 
Published: February 2007

AbstractEstrogen receptors (ERs) have recently been reported to be present in carcinomas of stomach, an organ that has so far been considered as nontarget for sex hormones. Cathepsin D is an estrogen‐regulated lysosomal protease that has been overexpressed in breast cancer. ER and cathepsin D immunohistochemical expression were studied in this research in order to estimate their association to known histopathological and clinical parameters and their possible prognostic significance as well.Sixty‐two patients with gastric adenocarcinomas were included in this study. The cancers were studied immunohistochemically concerning ER positivity in tumor cell nuclei and cathepsin D cytoplasmic expression.Nuclear ER staining was detected in tumor cells of 25% of male and 27% of female patients. ER positivity was demonstrated mainly in the well and moderately differentiated carcinomas; 87.5% of ER(+) tumors were also characterized as cathepsin D positive and a significant correlation between ER and cathepsin D positive expression was demonstrated (P < 0.05). Cytoplasmic cathepsin D expression was observed in carcinomatous cells of 70.9% of gastric tumors. Early tumor stage and good differentiation were significantly associated with increased cathepsin D expression (P < 0.05, P < 0.001). Histologic type, degree of differentiation and tumor stage were significantly correlated to survival (P < 0.05, P < 0.001 and P < 0.001). The patients who were cathepsin D(+) had a significant prognostic advantage over the cathepsin D(‐) patients (P < 0.001).The presence of ER and estrogen‐regulated cathepsin D indicates the involvement of sex hormonal factors in these tumors and cathepsin D positive expression in tumor cells seems to be related to better prognosis. Their biological, clinical, and prognostic roles remain to be further elucidated. © 1995 Wiley‐Liss, Inc.
Sclerosing mucoepidermoid carcinoma of the esophagus with intraepithelial carcinoma or dysplastic epithelium
Authors: Mafune Ken‐Ichi , Tanaka Yoichi , Fujita Kichishiro , Takubo Kaiyo 
Published: February 2007

AbstractMucoepidermoid carcinoma of the esophagus is a particularly rare lesion, and only 24 cases have been reported in the English literature. Using histochemical methods, we identified four (3.1%) of 135 resected primary esophageal cancers as mucoepidermoid carcinomas. Gross examination of these four tumors disclosed sclerosing submucosal infiltration with shallow surface ulceration, which had appeared as a funnel‐shaped constriction on esophagram. The intraepithelial spread of the tumor in two cases and the close relationship between foci of invading carcinoma and regions of dysplastic epithelium in the remaining two cases suggest that esophageal mucoepidermoid carcinoma may originate in the squamous epithelium. Although mucoepidermoid carcinoma should theoretically offer a fair prognosis, the outcome for patients with this lesion has generally been as poor as patients with typical squamous cell carcinoma. This further implies that mucoepidermoid carcinomas may arise from the squamous epithelium. © 1995 Wiley‐Liss, Inc.
Reexcision operations in nonpalpable breast cancer
Authors: Mokbel Kefah , Ahmed Mansoor , Nash Anthony , Sacks Nigel 
Published: February 2007

AbstractWe retrospectively reviewed the records of 317 needle‐localization (NL) biopsies performed at the Royal Marsden Hospital during 1989–1992. The malignancy yield in our centre, where there is an emphasis on cooperation with an experienced radiologist and breast pathologist, was 48% (151/317), with benign to malignant biopsy ratio of 1:1:1. Analysis of the histopathological findings of the malignant lesions revealed a 45% (68/51) incidence of positive microscopic margins. Of these 68 patients, 50 had re‐excisions, including nine patients who required mastectomy. Twentyeight of the re‐excisions (56%) contained residual tumour, of which five (18%) were invasive carcinoma > 3 mm (size range 1–19 mm) and 13 (46%) were residual DCIS > 1 mm (size range 1– 40 mm). Our findings suggest a significant incidence of residual disease associated with positive microscopic margins in NL‐detected nonpalpable cancers. Therefore, our current practice of performing a wider re‐excision for positive margins is justified. Stereotactic fine‐needle aspiration cytology was not performed by the radiologist referring these cases, but it should be performed preop‐eratively and if the test is positive, definitive treatment in the form of wide local excision or quadrantectomy is carried out in the first instance in order to avoid a second surgical procedure. © 1995 Wiley‐Liss, Inc.