bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are tumefactive lesions classified as sclerosing mesenteritis a subset of IgG4-related sclerosing disorders?
Authors: Chen T S , Montgomery E A 
Published: August 2008

Background:The relationship between tumefactive lesions classified as sclerosing mesenteritis and IgG4-related sclerosing disorders (eg, lymphoplasmacytic sclerosing pancreatitis/autoimmune pancreatitis) remains uncertain.Aims:To review lesions coded as “sclerosing mesenteritis” for findings in keeping with IgG4-related sclerosing disorders.Methods:Inclusion in the study required available paraffin blocks for IgG4 staining and documentation of a mass lesion.Results:A total of nine mesenteric lesions (3–14 cm) were identified in 6 male and 3 female patients. On H&E-stained sections, all were characterised as loosely marginated fibroinflammatory processes with variable amounts of fat necrosis. Lymphocytic venulitis/phlebitis was identified in 8 of 9 cases. IgG and IgG4 expression in lesional plasma cells was assessed by immunohistochemistry. IgG4-positive plasma cells were counted in the areas of greatest density in ⩾3 high power fields (HPFs). The highest number per HPF was recorded and a score assigned based on the following scale: <5/HPF, none/minimal; 5–10/HPF, mild; 11–30/HPF, moderate; >30/HPF, marked. The relative proportion of IgG4-reactive plasma cells to total IgG-positive plasma cells was assessed. IgG4-reactive plasma cells ranged from 0 to >100 in the most dense zones (3 cases, none/minimal; 4 cases, moderate; 2 cases, marked).Conclusions:Although this study is limited by small numbers, findings suggest that some tumefactive lesions regarded as sclerosing mesenteritis may be a subset of IgG4-related sclerosing disorders.
Hepatic giant cells in hepatitis C virus (HCV) mono-infection and HCV/HIV co-infection
Authors: Micchelli S T L , Thomas D , Boitnott J K , Torbenson M 
Published: August 2008

Background:The clinical and biological significance of syncytial giant cell change of hepatocytes in hepatitis C viral (HCV) infection is poorly understood.Aim:To investigate the clinical and histological correlates of giant cell transformation in the setting of HCV mono-infection and co-infection with HCV and HIV.Methods:The prevalence of hepatocyte giant cell transformation was determined and serological, biochemical and histological findings examined.Results:Among 856 liver biopsy specimens, 22 cases (2.6%) showed giant cell transformation, representing 18 individuals. The median serum ALT was 37 IU/l, AST 49 IU/l, and alkaline phosphatase 97 IU/l. Eleven cases had HCV RNA loads available, with a median HCV RNA of 5.52 log IU/ml. Twelve of 17 individuals with available test results were also HIV positive (71%), compared to 46% of controls (p = 0.08). Giant cell transformation was found exclusively in zone 3 hepatocytes; the accompanying histological findings were otherwise typical of chronic HCV. The hepatic giant cells typically had a cytoplasmic appearance that resembled smooth endoplasmic reticulum proliferation. Most cases had only mild inflammation and fibrosis, with a median modified hepatic activity index (MHAI) grade of 3/18 and a median MHAI stage of 1/6. Three individuals had follow-up biopsies; all continued to have giant cell change.Conclusion:Giant cell transformation occurs most commonly in the setting of HCV/HIV co-infection, but can also be seen in chronic HCV infection alone. Histologically, giant cells were located in zone 3 hepatocytes, were persistent over time, and do not appear to be a marker of aggressive hepatitis.
Cluster Analysis of North Atlantic–European Circulation Types and Links with Tropical Pacific Sea Surface Temperatures
Authors: Fereday D. R. , Knight J. R. , Scaife A. A. , Folland C. K. , Philipp A. 
Published: August 2008

Abstract
Observed atmospheric circulation over the North Atlantic–European (NAE) region is examined using cluster analysis. A clustering algorithm incorporating a “simulated annealing” methodology is employed to improve on solutions found by the conventional k-means technique. Clustering is applied to daily mean sea level pressure (MSLP) fields to derive a set of circulation types for six 2-month seasons. A measure of the quality of this clustering is defined to reflect the average similarity of the fields in a cluster to each other. It is shown that a range of classifications can be produced for which this measure is almost identical but which partition the days quite differently. This lack of a unique set of circulation types suggests that distinct weather regimes in NAE circulation do not exist or are very weak. It is also shown that the stability of the clustering solution to removal of data is not maximized by a suitable choice of the number of clusters. Indeed, there does not appear to be any robust way of choosing an optimum number of circulation types. Despite the apparent lack of preferred circulation types, cluster analysis can usefully be applied to generate a set of patterns that fully characterize the different circulation types appearing in each season. These patterns can then be used to analyze NAE climate variability. Ten clusters per season are chosen to ensure that a range of distinct circulation types that span the variability is produced. Using this classification, the effect of forcing of NAE circulation by tropical Pacific sea surface temperature (SST) anomalies is analyzed. This shows a significant influence of SST in this region on certain circulation types in almost all seasons. A tendency for a negative correlation between El Niño and an anomaly pattern resembling the positive winter North Atlantic Oscillation (NAO) emerges in a number of seasons. A notable exception is November–December, which shows the opposite relationship, with positive NAO-like patterns correlated with El Niño.
On Scatterometer Ocean Stress
Authors: Portabella M. , Stoffelen A. 
Published: August 2008

Abstract
Scatterometers estimate the relative atmosphere–ocean motion at spatially high resolution and provide accurate inertial-scale ocean wind forcing information, which is crucial for many ocean, atmosphere, and climate applications. An empirical scatterometer ocean stress (SOS) product is estimated and validated using available statistical information. A triple collocation dataset of scatterometer, and moored buoy and numerical weather prediction (NWP) observations together with two commonly used surface layer (SL) models are used to characterize the SOS. First, a comparison between the two SL models is performed. Although their roughness length and the stability parameterizations differ somewhat, the two models show little differences in terms of stress estimation. Second, a triple collocation exercise is conducted to assess the true and error variances explained by the observations and the SL models. The results show that the uncertainty in the NWP dataset is generally larger than in the buoy and scatterometer wind/stress datasets, but it depends on the spatial scales of interest. The triple collocation analysis also shows that scatterometer winds are as close to real winds as to equivalent neutral winds, provided that the appropriate scaling is used. An explanation for this duality is that the small stability effects found in the analysis are masked by the uncertainty in SL models and their inputs. The triple collocation analysis shows that scatterometer winds can be straightforwardly and reliably transformed to wind stress. This opens the door for the development of wind stress swath (level 2) and gridded (level 3) products for the Advanced Scatterometer (ASCAT) on board Meterological Operation (MetOp) and for further geophysical development.
The Temporal Aliasing Formulas for the Tandem Mission of Jason-1 and TOPEX/Poseidon
Authors: Tai Chang-Kou 
Published: August 2008

Abstract
The temporal aliasing formulas are derived for the Tandem Mission of Jason-1 and the Ocean Topography Experiment (TOPEX)/Poseidon. Previously, aliasing formulas were derived for a single satellite or a constellation of coordinated satellites, wherein the coordination is such that the collective samplings appear as if they were carried out by a single satellite. In this vein, Jason-1 and TOPEX/Poseidon are coordinated spatially but not temporally. The problem is treated as a general problem about the temporal phasing between any two satellites that are coordinated spatially so that the Tandem Mission is just one special case, whereas the temporally coordinated case is another special case. The present results do agree with the formulas for a constellation of coordinated satellites when the temporal phasing yields temporal coordination, as they should. The benefit of temporal coordination shows itself as having a higher spatial resolution for temporally aliased features. The physical implication is twofold. First, a high-frequency and low-wavenumber feature (e.g., the barotropic Rossby waves) has a better chance of being aliased as a low-frequency and higher-wavenumber feature in a perfectly coordinated mission than it has in the Tandem Mission. Second, in a perfectly coordinated mission, a high-frequency and high-wavenumber feature could be aliased as a low-frequency and high-wavenumber feature rather than as a low-frequency and low-wavenumber feature in the Tandem Mission. Despite the extreme mathematical complexity, the physical case is rather intuitive. Namely, the two satellites need temporal coordination to work as one in fending off temporal aliasing. Without it, the two satellites behave as two independent satellites, thus each reverting to their original (i.e., lower) spatial resolution capability in dealing with temporal aliasing.
Mixing Measurements on an Equatorial Ocean Mooring
Authors: Moum J. N. , Nash J. D. 
Published: August 2008

Abstract
Vaned, internally recording instruments that measure temperature fluctuations using FP07 thermistors, including fluctuations in the turbulence wavenumber band, have been built, tested, and deployed on a Tropical Atmosphere Ocean (TAO) mooring at 0°, 140°W. These were supplemented with motion packages that measure linear accelerations, from which an assessment of cable displacement and speed was made. Motions due to vortex-induced vibrations caused by interaction of the mean flow with the cable are small (rms &lt; 0.15 cable diameters) and unlikely to affect estimates of the temperature variance dissipation rate χT. Surface wave–induced cable motions are significant, commonly resulting in vertical displacements of ±1 m and vertical speeds of ±0.5 m s−1 on 2–10-s periods. These motions produce an enhancement to the measurement of temperature gradient in the surface wave band herein that is equal to the product of the vertical cable speed and the vertical temperature gradient (i.e., dT/dt ∼ wcdT/dz). However, the temperature gradient spectrum is largely unaltered at higher and lower frequencies; in particular, there exists a clear scale separation between frequencies contaminated by surface waves and the turbulence subrange. The effect of cable motions on spectral estimates of χT is evaluated and determined to result in acceptably small uncertainties (&lt; a factor of two 95% of the time, based on 60-s averages). Time series of χT and the inferred turbulent kinetic energy dissipation rate ε are consistent with historical data from the same equatorial location.
Effect of melatonin, curcumin, quercetin, and resveratrol on acute ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative damage in rats
Authors: Eybl V , Kotyzová D , Černá P , Koutenský J 
Published: August 2008

The influence of melatonin, curcumin, quercetin, and resveratrol pretreatment on ferric nitrilotriacetate (Fe-NTA)-induced oxidative renal damage was studied. Male Wistar rats were treated orally once daily for 3 days with melatonin (10 mg/kg), curcumin (50 mg/kg), quercetin (15 mg/kg), and resveratrol (10 mg/kg). One hour after the last dose of antioxidants, a single dose of Fe-NTA was administered (8 mg of Fe/kg body weight, i.p.) to pre-treated animals. Twenty-four hours after Fe-NTA administration, the lipid peroxidation (LP), reduced glutathione (GSH), catalase (CAT), and glutathione peroxidase (GSH-Px) were estimated in kidney homogenates. Iron, zinc, and copper concentrations were estimated in kidney tissue. Administration of Fe-NTA to rats induced renal LP (170%, P < 0.001) and inhibited catalase (78%, P < 0.05) in the kidney. The oral pretreatment with melatonin, curcumin, quercetin, and resveratrol each one was effective in decreasing the Fe-NTA-induced LP ( P < 0.001); however, it did not influence the FeNTA-induced inhibition of renal CAT activity. No changes were found in renal GSH level and GSH-Px activity compared to control animals. The pretreatment with antioxidants did not affect the increase in renal iron content, blood urea nitrogen/creatinine ratio, and relative kidney weight of FeNTA-intoxicated rats. The results indicate that the pretreatment with natural antioxidants, curcumin, melatonin, quercetin, and resveratrol, significantly and equally suppressed lipid peroxidation induced by Fe-NTA but had no effect on other markers of FeNTA nephrotoxicity and iron deposition in kidneys.
Pulmonary rehabilitation and follow-on services: a Northern Ireland survey
Authors: O’Neill B , Elborn JS , MacMahon J , Bradley JM 
Published: August 2008

There should be a clear pathway through pulmonary rehabilitation and follow-on services. The aim of this survey was to determine the characteristics of the different components of the patient pathway, that is, pulmonary rehabilitation programs, ongoing exercise facilities, and support networks in Northern Ireland. Questionnaires were sent to current providers of pulmonary rehabilitation, providers of ongoing exercise, and support groups in Northern Ireland. Findings relating to the current status of pulmonary rehabilitation in Northern Ireland up to January 2007 are reported. There are currently 23 pulmonary rehabilitation programs in Northern Ireland. There appears to be a pathway through the short-term pulmonary rehabilitation program (6–8 weeks). Programs met standards for structure and format, except for the frequency of supervised exercise. Not all programs have links for the provision of ongoing exercise, but a range of exercise programs are available in leisure centers in Northern Ireland that include people with respiratory disease. There are 13 support groups for patients with respiratory disease in Northern Ireland and their function is diverse. Pulmonary rehabilitation is established in Northern Ireland, although not all patients are able to access these. Facilities for ongoing exercise and support groups are less developed. Improvements could be facilitated by better communication within the patient pathway and a strategic coordinated approach.
Male and Female Adult Population Health Status in China: A Cross-Sectional National Survey
Authors: Shi Jing , Liu Meina , Zhang Qiuju , Lu Mingshan , Quan Hude 
Published: August 2008

Abstract

Background
With rapid economic growth and globalization, lifestyle in China has been changing dramatically. This study aimed to describe the male and female adult Chinese population health status.

Methods
The Chinese Third National Health Services Survey was conducted in 2003 to collect information about health status and quality of life from randomly selected residents. Of the 193,689 respondents to the survey (response rate 77.8%), 139,831 (69,748 male and 70,083 female) respondents who were 18 years of age or older were analyzed.

Results
Among the respondents, fewer males than females rated their overall wellbeing as being poor or very poor (4.8% versus 6.2%), reported illness in the last 2 weeks (14.1% versus 17.4%), presence of physician diagnosed chronic disease (15.0% versus 17.7%) and at least one functional problem in seven items of the quality of life (26.9% versus 32.8%). More males than females were currently smoking (52.4% versus 3.4%) and drank alcohol more than three times per week (16.5% versus 1.1%). Physically inactive rate was similar between males and females (85.8% versus 87.0%). Fewer rural respondents reported chronic disease than urban respondents (13.0% versus 19.9% for males and 15.5% versus 22.8% for females). In all seven items of the quality of life measured, rural respondents reported less problems than urban respondents (26.2% versus 28.7% for males and 32.0% versus 34.7% for females).

Conclusion
Males had better health status than females in terms of self-perceived wellbeing, presence of illness, chronic disease, and quality of life. However, smoking and frequent alcohol drinking was more prevalent among males than that among females. In contrast with the social-economic gradient in health commonly found in the literature, the wealthier urban population in China was not found to be healthier than the rural population in terms of physician diagnosed chronic disease.
The Cervical Dystonia Impact Profile (CDIP-58): Can a Rasch developed patient reported outcome measure satisfy traditional psychometric criteria?
Authors: Cano Stefan J , Warner Thomas T , Thompson Alan J , Bhatia Kailash P , Fitzpatrick Ray , Hobart Jeremy C 
Published: August 2008

Abstract

Background
The United States Food and Drug Administration (FDA) are currently producing guidelines for the scientific adequacy of patient reported outcome measures (PROMs) in clinical trials, which will have implications for the selection of scales used in future clinical trials. In this study, we examine how the Cervical Dystonia Impact Profile (CDIP-58), a rigorous Rasch measurement developed neurologic PROM, stands up to traditional psychometric criteria for three reasons: 1) provide traditional psychometric evidence for the CDIP-58 in line with proposed FDA guidelines; 2) enable researchers and clinicians to compare it with existing dystonia PROMs; and 3) help researchers and clinicians bridge the knowledge gap between old and new methods of reliability and validity testing.

Methods
We evaluated traditional psychometric properties of data quality, scaling assumptions, targeting, reliability and validity in a group of 391 people with CD. The main outcome measures used were the CDIP-58, Medical Outcome Study Short Form-36, the 28-item General Health Questionnaire, and Hospital and Anxiety and Depression Scale.

Results
A total of 391 people returned completed questionnaires (corrected response rate 87%). Analyses showed: 1) data quality was high (low missing data ≤ 4%, subscale scores could be computed for > 96% of the sample); 2) item groupings passed tests for scaling assumptions; 3) good targeting (except for the Sleep subscale, ceiling effect = 27%); 4) good reliability (Cronbach's alpha ≥ 0.92, test-retest intraclass correlations ≥ 0.83); and 5) validity was supported.

Conclusion
This study has shown that new psychometric methods can produce a PROM that stands up to traditional criteria and supports the clinical advantages of Rasch analysis.
Correction: RNA interference-mediated gene silencing in murine T cells: in vitro and in vivo validation of proinflammatory target genes
Authors: Gust Tatjana C , Neubrandt Luisa , Merz Claudia , Asadullah Khusru , Zügel Ulrich , von Bonin Arne 
Published: August 2008

Abstract
T cells play a central role in many inflammatory diseases, hence the identification and validation of T cell-specific target genes will increase the understanding of T cell function in pathologic inflammatory situations. RNA interference (RNAi), with its ability to induce specific gene silencing in mammalian cells, represents a powerful technology to investigate and validate the function of pharmaceutical target genes in vitro and in vivo. The aim of the present study was to systematically explore RNAi-mediated gene-silencing of known T cell-specific model signaling molecules in primary murine T cells in vitro and in vivo. We demonstrate that siRNA delivery and subsequent silencing of T cell specific genes is substantially increased, if murine T cells were activated prior siRNA transfection. Silencing of ZAP70, p56Lck as well as PLC-γ1 protein expression resulted in impaired function of T cells in vitro. Furthermore, delayed type hypersensitivity (DTH) was ameliorated in vivo after adoptive transfer of ZAP70-silenced T cells. The combination of RNAi-mediated gene silencing and adoptive transfer of gene-silenced T cells, thus, may allow the identification and analysis of T cell-specific targets for therapeutic intervention. Additionally, this model system may represent an alternative to conventional time consuming and cost intensive gene targeting approaches.
Increased susceptibility to collagen-induced arthritis in female mice carrying congenic Cia40/Pregq2fragments
Authors: Liljander Maria , Andersson Åsa , Holmdahl Rikard , Mattsson Ragnar 
Published: August 2008

Abstract
Introduction
Collagen-induced arthritis (CIA) in mice is a commonly used experimental model for rheumatoid arthritis (RA). We have previously identified a significant quantitative trait locus denoted Cia40 on chromosome 11 that affects CIA in older female mice. This locus colocalizes with another locus, denoted Pregq2, known to affect reproductive success. The present study was performed to evaluate the role of the Cia40 locus in congenic B10.Q mice and to identify possible polymorphic candidate genes, which may also be relevant in the context of RA.

Methods
Congenic B10.Q mice carrying an NFR/N fragment surrounding the Cia40/Pregq2 loci were created by 10 generations of backcrossing (N10). The congenic mice were investigated in the CIA model, and the incidence and severity of arthritis as well as the serum levels of anti-collagen II (CII) antibodies were recorded.

Results
Significant effects on onset, incidence, severity, and anti-CII antibody titers were observed in female mice carrying a heterozygous congenic Cia40/Pregq2 fragment of NFR/N origin, containing one or more polymorphic genes. Congenic male mice did not show increased incidence of CIA, but males carrying a heterozygous fragment showed a significant increase in severity in comparison with wildtype B10.Q males (littermates).

Conclusion
The Cia40/Pregq2 locus at chromosome 11 contains one or more polymorphic genes of NFR/N origin that significantly influence both incidence and severity of CIA in heterozygous congenic mice of the B10.Q strain. The major polymorphic candidate genes for the effects on CIA are Cd79b, Abca8a, and Map2k6. The congenic fragment also contains polymorphic genes that affect reproductive behavior and reproductive success. The Sox9 gene, known to influence sex reversal, is a candidate gene for the reproductive phenotype.
Factors Involved in Drug-Produced Model Psychoses
Authors: Fischer Roland 
Published: August 2008

The use of fibrous wool protein as a model of the structural surface of receptors, possibly involved in the mechanism producing a model psychosis by drugs, was suggested by three lines of evidence.First, the strong affinity (sorption) of certain basic compounds to keratins of low sulphur content as exemplified by the Gram-positiveness of epidermal (Fischer, 1953c) and nervous (Bailey, 1950) tissue.Second, the accumulating evidence indicating the similarity in behaviour between keratins of high sulphur content (e.g. wool) and the protein component of certain cell membranes (Fischer, 1951; Fischer and Larose, l952a;idem, 1952b; Larose and Fischer, 1952;idem, l953a and 1953b).Third, some preliminary experiments confirming the role of wool protein as a useful model to simulate some of those receptors for which certain drugs appear to compete.