bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis of artificial hypoglycemia due to oral hypoglycemic drugs by high-performance liquid chromatography with tandem mass spectrometric detection
Authors: Yukina M. Y. , Troshina E. A. , Nuralieva N. F. , Ioutsi V. A. , Rebrova O. Y. , Mel’nichenko G. A. , Mokrysheva N. G. 
Published: March 2024

BACKGROUND: Artificial hypoglycemia (ArH) is a decrease of blood glucose levels less than 3 mmol/l due to the deliberate use of hypoglycemic drugs by a patient outside of medical appointments. Timely diagnosis of this kind of hypoglycemia avoids unnecessary numerous examinations and hospitalizations. However, the detection of ArH still remains an extremely difficult task for both the healthcare facility and the attending physician. The foreign literature describes cases of successful detection of deliberate intake of oral hypoglycemic drugs (OHD) using high-performance liquid chromatography with tandem mass spectrometric detection (HPLC-MS/MS). Thus, it is relevant to develop and validate a method for determining OHD using HPLC-MS/MS.AIM: To optimize the diagnosis of ArH due to the use of OHD.MATERIALS AND METHODS: A total of 92 patients were examined. The development of the HPLC-MS/MS method for the detection of the studied OHD (sOHD; n=1-glibenclamide, n=1-gliquidone, n=1-gliclazide, n=1-glimepiride, n=1-glipizide, n=1-nateglinide and n=1-repaglinide) in the blood was carried out in a group of patients with diabetes mellitus type 2 (n=7) who received sOHD, and a group of conditionally healthy people who did not receive any medications (n= 7). To validate the method, the determination of sOHD substances was carried out on groups of patients with hyperinsulinemic nondiabetic hypoglycemia (NDH) of unknown origin (n=11) and with insulinoma (n=67).RESULTS: In the study of blood samples by HPLC-MS/MS in the group of patients with diabetes mellitus type 2, was confirmed in 100% of the cases the use of the drug that the patient received, in the group of conditionally healthy — sOHD were not detected. A false positive result was not obtained in any conditionally healthy and in any patient with insulinoma. ArH was diagnosed in 5 out of 11 patients in the group with hyperinsulinemic NDH of unknown origin, the method identified sOHD glibenclamide and gliclazide in the patients’ blood samples. In the remaining 6 patients of this group, examinations were continued and other causes of NDH were diagnosed. The sensitivity of the method was 100% [74%; 100%], specificity — 100% [95%; 100%].CONCLUSION: The HPLC-MS/MS method has high diagnostic accuracy in the detection and identification of sOHD (glibenclamide, gliquidone, gliclazide, glimepiride, glipizide, nateglinide and repaglinide) in blood samples of patients receiving these drugs. Currently, due to the low availability of the method, this study is advisable to use in patients with hyperinsulinemic hypoglycemia with negative results of first-line insulinoma imaging methods (computed tomography with contrast enhancement, ultrasound and magnetic resonance imaging of the abdominal cavity).
The diachrony of the Basque marker bait-: from a manner expression to subordinator
Authors: Krajewska Dorota 
Published: March 2024

Abstract
This article analyzes the diachrony of the Basque marker bait-, which is a verbal prefix in subordinate clauses, but also has other functions: for example, it appears in independent clauses and indefinite pronouns. In subordinate clauses, it is used in two ways. First, it co-occurs with clause-initial conjunctions in reason, manner or result clauses or with pronouns in relative clauses. Secondly, it is used on its own, in relative, reason, result and complement clauses (with a limited group of verbs, such as emotive factive predicates or predicates of happening). The article combines evidence from a corpus study (6822 examples from 16th- to 20th-century texts) and internal reconstruction to (1) determine if and in what way the subordinator bait- and the affirmative bai ‘yes’ can be diachronically related, and (2) try to establish diachronic relations between the functions of bait-. It is proposed that the missing link between the subordinator and the affirmative particle might be a manner expression bai which had anaphoric functions. The marker bait- emerged as a reanalyzed form of the manner expression, which then gradually and through various pathways spread to different types of subordinate clauses and was reanalyzed as a subordinator.
Coupling of Sharp Wave Events between Zebrafish Hippocampal and Amygdala Homologues
Authors: Blanco Ismary , Caccavano Adam , Wu Jian-Young , Vicini Stefano , Glasgow Eric , Conant Katherine 
Published: March 2024

The mammalian hippocampus exhibits spontaneous sharp wave events (1-30 Hz) with an often-present superimposed fast ripple oscillation (120-220 Hz) to form a sharp wave ripple (SWR) complex. During slow-wave sleep or quiet restfulness, SWRs result from the sequential spiking of hippocampal cell assemblies initially activated during learned or imagined experiences. Additional cortical/subcortical areas exhibit SWR events that are coupled to hippocampal SWRs, and studies in mammals suggest that coupling may be critical for the consolidation and recall of specific memories. In the present study, we have examined juvenile male and female zebrafish, and show that SWR events are intrinsically generated and maintained within the telencephalon and that their hippocampal homologue, the anterodorsolateral lobe (ADL), exhibits SW events with approximately 9% containing an embedded ripple (SWR). Single-cell calcium imaging coupled to local field potential (LFP) recordings, revealed that approximately 10% of active cells in the dorsal telencephalon participate in any given SW event. Furthermore, fluctuations in cholinergic tone modulate SW events consistent with mammalian studies. Moreover, the basolateral amygdala (BLA) homologue exhibits SW events with approximately 5% containing an embedded ripple. Computing the SW peak coincidence difference between the ADL and BLA showed bidirectional communication. Simultaneous coupling occurred more frequently within the same hemisphere, and in coupled events across hemispheres, the ADL more commonly preceded BLA. Together, these data suggest conserved mechanisms across species by which SW and SWR events are modulated, and memories may be transferred and consolidated through regional coupling.Significance StatementWe provide a comprehensive analysis of spontaneous activity within the telencephalon of juvenile zebrafish, demonstrating that SWR events are intrinsically generated and maintained within this structure. SWs are modulated by the cholinergic system and possibly other cortical/subcortical areas. We also show that SW events are associated with neuronal ensemble activity. Additionally, we provide evidence that the BLA exhibits SWR events. Spontaneous activity between the ADL and BLA shows bidirectional communication, which suggests conserved mechanisms by which learned experiences are transferred and consolidated in this vertebrate. These findings showcase conserved memory-related mechanisms between mammals and zebrafish, and further support the use of zebrafish to better understand molecular mechanisms that interfere with processes critical to learning and memory consolidation.
Efektifitas Penerapan Hybrid Learning dalam Meningkatkan Prestasi Belajar Pendidikan Agama Islam (PAI) dan Budi Pekerti Peserta Didik Kelas VI SDN Sidotopo I/ 48 Surabaya Pada Era New Nornal
Authors: Taufiq Moh. Taufiq 
Published: March 2024

Abstract: Covid-19 pandemic caused significant changes. Suddenly, all levels of education were forced to adapt conduct distance learning (PJJ) from home or online. This is certainly not an easy cases, because they are not fully ready and actively contributed. During the COVID-19 pandemic, especially in the new normal era, Hybrid learning is an ideal solution to various problems that occur in education fields. SDN Sidotopo I/48 as one of the schools that implements this learning model is the main attraction for researchers to conduct especially its application in improving the learning achievement of Islamic religious education (PAI) and the character of class VI students. Therefore, the application is expected to be able to facilitate educators in achieving the objectives of the material presented, especially in the subjects of Islamic Religious Education/PAI and Characters. The method used in this research is a qualitative research method with an ethnographic and phenomenological approach. Thus the results of the research found in this study stated that the Hybrid learning implementation of Islamic Religious Education /PAI and Budi Pekerti/Characters Class VI SDN Sidotopo I/48 Surabaya in the New Normal Era in improving learning achievement was quite effective, this can be seen from the observations results and list of values ​​held by Islamic Religious Education /PAI teachers and Budi Pekerti/Character during the learning process in pandemic to new normal era.
Optimasi Strategi Kolaborasi dalam Mengatasi Tantangan Tugas Kelompok Social Loafing Mahasiswa
Authors: Fitriyah Farihatil 
Published: March 2024

Penelitian ini perlu dikaji lebih mendalam untuk menginvestigasi adanya tantangan dalam tugas kelompok social loafing mahasiswa. Faktor penghambat yang berasal dari dalam diri mahasiswa yaitu karena kurangnya pemahaman tugas dan materi yang diberikan oleh dosen sehingga malas untuk mengerjakan, sikap malas yang juga menjadi penghambat mahasiswa untuk mengerjakan tugas kelompok karena sibuk dengan hiburan. Sedangkan faktor penghambat yang berasal dari luar diri mahasiswa salah satunya yaitu karena pengaruh lingkungan baik dari teman ataupun keluarga. Penelitian ini bertujuan untuk mengoptimalkan strategi kolaborasi dalam menghadapi tantangan tugas kelompok agar semua mahasiswa aktif mengerjakan. Dalam penelitian ini menggunakan metode kualitatif dengan menggunakan studi kepustakaan. Artikel ini berargumentasi bahwa dengan adanya tugas kelompok dapat membuat mahasiswa lalai mengerjakan tugas sebagai tanggung jawabnya. Dalam tugas kelompok mahasiswa lebih cenderung mengandalkan temannya yang pintar dalam mengerjakan tugasnya. Thesis statement ini sama dengan pendapat Mello, Sudjana, Fitri dan Kusumaningtyas. Thesis statement ini tidak sama dengan pendapat Gordon, Prayitno, dan Jhonson.
Perlindungan Hukum Pengguna Jasa Titip Beli Melalui Sosial Media Instagram
Authors: Ambaretha Rosi 
Published: March 2024

Abstract
Standard agreements in the business of buying and selling services on Instagram are deemed insufficient to protect the rights of consumers who use their services. So that it raises criticism about how the legal relationship between business actors and consumers is in the purchase- trust service agreement through Instagram social media so that it can be seen what the characteristics of the deposit-purchase service agreement on Instagram actually are, and what is the form of liability for business actors in the deposit-purchase service agreement on Instagram. this. This study can be categorized as doctrinal research studies which uses a conceptual and statutes approach to answer and analyze the trust-purchase service agreement on Instagram. In fact, what are the characteristics of the agreement so that the form of accountability of business actors in this Instagram-purchase service agreement is what about the guidelines in the Civil Code and Laws. No. 8 of 1999 concerning Consumer Protection Law.

Keywords: Buy-entrust Service Agreement, Instagram social media, Law no. 8 of 1999, standard agreement

Abstrak
perjanjian standart dalam usaha jasa titip beli di Instagram dirasa kurang cukup melindungi hak-hak konsumen pengguna jasanya. Sehingga memunculkan adanya kritikan mengenai bagaimana hubungan hukum pelaku usaha dan konsumen dalam perjanjian jasa titip beli melalui media sosial Instagram agar dapat diketahui seperti apa karakteristik perjanjian jasa titip beli di Instagram ini sebenarnya, serta bagaimana bentuk pertanggung gugtan pelaku usaha dalam perjanjian jasa titip beli di Instagram ini. Penelitian ini merupakan tipe penelitian hukum berjenis doctrinal research dan menggunakan pendekatan konseptual serta perundang-undangan untuk menjawab dan menganalisis perjanjian jasa titip beli di Instagram ini sebenarnya masuk kedalam karakteristik perjanjian apa sehingga bentuk tanggung gugat pelaku usaha dalam perjanjian jasa titip beli di Instagram ini bagaimana dengan perbedoman pada Kitab Undang-Undang Hukum Perdata dan Undang-Undang No.8 Tahun 1999 tentang Hukum Perlindungan Konsumen.
Kata Kunci: Perjanjian Jasa titip Beli, media sosial Instagram, Undang – Undang No. 8 Tahun 1999, perjanjian baku
Pertanggungjawaban Pidana Terhadap Pelaku Perbuatan Kekerasan Berbasis Gender Online Dengan Tipe Morphing
Authors: Syafirah Khansa Aribah Milansari  
Published: March 2024

Abstract
This study aims to look at the KBGO with the morphing type using a criminal law point of view and to see the criminal responsibility of the perpetrators of morphing. Currently, the regulations regarding KBGO, in this case, morphing, are still insufficient to enforce the law on the existence of online gender-based violence, online gender-based violence has the urgency to be discussed. At least. It can be seen that the main problem brought only to the occurrence of the criminal act of making, distributing, or providing pornography and the criminal act of manipulating Electronic Information or Electronic Documents with the aim that the Electronic Information or Electronic Documents are considered as if the data were authentic. In fact, in the realization of the crime, online gender-based violence has occurred, which in this paper has become a legal issue to be discussed.

Keywords: online gender-based violence, morphing, criminal liability.

Abstrak
Penelitian ini bertujuan untuk melihat KBGO dengan tipe morphing menggunakan sudut pandang hukum pidana dan melihat pertanggungjawaban pidana pelaku morphing. Saat ini peraturan mengenai KBGO, dalam hal ini morphing, masih belum cukup untuk melakukan penegakan hukum atas adanya perbuatan kekerasan berbasis gender online. Setidaknya. dapat dilihat bahwa persoalan utama yang dibawa hanya pada terjadinya tindak pidana membuat, menyebarluaskan, atau menyediakan pornografi dan tindak pidana melakukan manipulasi Informasi Elektronik dan/atau Dokumen Elektronik dengan tujuan agar Informasi Elektronik dan/atau Dokumen Elekronik tersebut dianggap seolah-olah data yang otentik.

Kata Kunci: Kekerasan berbasis gender online, morphing, pertanggungjawaban pidana.
Pertanggungjawaban Indonesia Sebagai Negara Peratifikasi Konvensi Perlindungan Hak-Hak Seluruh Pekerja Migran Dan Anggota Keluarganya
Authors: Zati Rizqi Muhammad  
Published: March 2024

Abstract
Indonesia has ratified the International Convention on the Protection of the Rights of All Migrant Workers and Members of Their Families (ICMW 1990) through Law Number 6 of 2012. Due to this ratification, Indonesia has various obligations to protect migrant workers entering the country to their jurisdiction regardless of their migration status under the agreement's contents. However, in practice, the Indonesian government has not taken the protection of migrant workers seriously, wildly irregular migrant workers. Therefore, the formulation of the problem includes the protection of foreign migrant workers in Indonesia and the legal consequences for Indonesia if it does not protect migrant workers under the agreement's contents. Therefore, this research is normative juridical research using a statutory and conceptual approach.

Keywords: ICMW 1990, immigration status, migrant workers

Abstrak
Indonesia telah melakukan ratifikasi International Convention on the Protection of the Rights of All Migrant Workers and Members of Their Families (ICMW 1990) melalui Undang-Undang Nomor 6 Tahun 2012. Konsekuensi dari melakukan ratifikasi ini, Indonesia dibebankan berbagai kewajiban untuk melindungi pekerja migran yang masuk ke wilayah hukumnya tanpa melihat status migrasinya sesuai dengan isi perjanjian. Namun pada prakteknya, Pemerintah Indonesia belum melakukan perlindungan pada pekerja migran dengan serius, khususnya pekerja migran irregular. Rumusan masalah antara lain perlindungan pekerja migran asing di Indonesia serta akibat hukum Indonesia bila tidak melakukan perlindungan pekerja migran sesuai dengan isi perjanjian. Penelitian ini merupakan penelitian yuridis normatif menggunakan pendekatan perundang-undangan (statute approach) serta pendekatan konseptual (conseptual approach).

Kata Kunci: ICMW 1990, status migrasi, pekerja migran
Associations between HEXACO personality traits, substance use disorders and behavioral addictions: A protocol for a comprehensive systematic review and meta-analysis
Authors: Sharifibastan Farangis , Erevik Eilin Kristine , Morken Katharina Teresa Enehaug , Pallesen Ståle 
Published: March 2024

Abstract

Background
While ample research has examined the connections between addiction and personality in general, there has yet to be a systematic study that investigates how various substance use disorders (SUD) and behavioural addictions are related to the dimensions of the HEXACO model of personality. This systematic review and meta-analysis aim to address this gap by comprehensively exploring the association between HEXACO personality traits and addiction disorders, including illegal substances (e.g., all narcotics in one group and cannabis in a separate category), and behavioural addictions (e.g., gambling and gaming problems, social media addiction, and compulsive sexual behaviour disorder; CSBD), within all types of sample populations.
Methods
The present paper will carry out a systematic review of the available literature using the Preferred Reporting Items for Systematic Review and Meta Analyses (PRISMA) guidelines. Searches will be conducted in databases including APA PsycINFO (Ovid), Medline (Ovid), ProQuest, Web of Science, CINAHL, and Wiley Online Library, and Google Scholar. Included studies will adhere to the following criteria: (1) original articles, published as full papers; (2) studies published in English or other European languages or Persian; (3) published in a peer-reviewed journal; (4) studies investigating the association between HEXACO personality traits and addictive disorders, including illegal substances (e.g., all narcotics and cannabis as separate categories), and behavioural addictions (e.g., gambling and gaming problems, social media addiction, and CSBD), within all types of sample populations. (5) Research reporting Pearson’s or Spearman’s r correlation coefficients of the variables of interest or any data that could be converted into a correlation coefficient, such as Cohen’s d/f, T value, F values, or Fishers Z will be included. Two researchers will independently screen all citations, full-text articles, and extract data. Risk of bias of the included studies will be assessed by the Newcastle-Ottawa Quality Assessment Scale (NOS), and Mixed Methods Appraisal Tool (MMAT). Data will be synthesized using a meta-analysis if the data are sufficient. Subgroup analyses will be conducted to investigate the impact of various moderators on effect sizes, and sensitivity analyses will examine the robustness of the results. Data analysis will be conducted in Stata 18 packages.
Discussion
This review and meta-analysis will be the first to systematically explore and integrate the evidence available on the association between the HEXACO personality traits and SUD and behavioural addictions. By consolidating information, the study enhances our understanding of the role of personality traits in the development and maintenance of SUD and behavioural addictions.
Systematic review registration:
PROSPERO CRD42023468153
Associations Between Anemia and Dependence on Basic and Instrumental Activities of Daily Living in Older Women
Authors: Karismaz Abdulkadir , Pasin Ozge , Kara Osman , Eren Rafet , Smith Lee , Doventas Alper , Soysal Pinar 
Published: March 2024

Abstract

Aim
The aim of the present study was to examine the relationship between anemia and basic and instrumental activities of daily living in older female patients.
Methods
540 older female outpatients were included. Anemia was defined as a hemoglobin below 12 g/dL. Patients' demographic characteristics, comorbidities, Geriatric Depression Scale, Mini Nutritional Assessment, and Mini-Mental State Examination (MMSE) were also recorded. Handgrip strength (HGS) was measured with a hand dynamometer to detect dynapenia. Basic Activities of Daily Living (BADL) and Instrumental Activities of Daily Living (IADL) questionnaires were used to evaluate functional capacity.
Results
The mean age of the participants was 77.42 ± 7.42. The prevalence of patients with anemia was 35%. A significant difference was observed between anemic and non-anemic groups in terms of age, presence of diabetes mellitus, hypertension, (DM) coronary artery disease (CAD), chronic kidney disease (CKD), malnutrition, dynapenia, and MMSE, BADL and IADL scores (p < 0.05). In multivariate analysis, after adjustment for age, DM, hypertension, CAD and CKD; there were significant associations between anemia and reduced BADL/IADL scores, dynapenia, falls, the risk of falls, MMSE, and malnutrition (p < 0.05). After adjusting for all confounding variables, deterioration in total BADL and IADL total scores were still more common among anemic older females than those without anemia (p < 0.05).
Conclusion
One out of every three older women presenting at outpatient clinic were anemic. Anemia was observed to be associated with dependence in both BADL and IADL measures. Therefore, the presence of anemia in elderly women should be routinely checked, and possible causes should be investigated and treated to improve their functional capacity.
Elucidating the Prognostic Biomarkers and Immune Correlations in the Co- occurrence of Chronic Obstructive Pulmonary Disease and Lung Squamous Cell Carcinoma
Authors: Hui Li , Qi Wu , Ping Liu , Yuling Tang , Yubin Fan , Wenfang Tang , Yanyan Fang , Linyan Xu , Bin Li , Ting Guo , Xuelian Chen 
Published: March 2024

Abstract

Background: Chronic obstructive pulmonary disease (COPD) elevated the risk of lung squamous cell carcinoma (LUSC), but the underlying molecular links and their effects on disease progression were unclear.
Methods: This study performed a comprehensive analysis of microarray and RNA-Seq data from six independent cohorts to identify key differentially expressed genes (DEGs) between COPD and LUSC patients. It conducted survival analysis using the TCGA-LUSC dataset and constructed a risk prediction model for the identified DEGs through LASSO regression, accounting for smoking history in LUSC-TCGA patients. The immune correlations and tumor immunophenotype profiling of the risk model were further analyzed.
Results: Distinct gene expression profiles were identified in patients with both COPD and LUSC compared to those with either condition alone, with seven genes showing significant dysregulation. This suggested a unique molecular signature for combined disease pathology. PTPN3 and ADH1C were pinpointed as potential prognostic biomarkers using a LASSO model. These genes also demonstrated negative correlations with various immune cells and positive correlations with tumor-promoting processes.
Conclusion: This study reveals the molecular connection between COPD and LUSC, pinpointing biomarkers for disease evolution and therapeutic response, and emphasizes the intricate treatment dynamics due to COPD's genetic and immune influences on LUSC prognosis