bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brian Collier (1940–2024)
Authors: Prado Marco A. M. , Tandon Anurag 
Published: February 2024

AbstractDr. Brian Collier, the former Editor‐in‐Chief of the Journal of Neurochemistry from 1996 to 2006, passed away January 4th, 2024. Brian's illustrious career spanned the fields of neurochemistry and pharmacology. He published his findings on mechanisms of acetylcholine synthesis and storage in the Journal of Neurochemistry, and his contributions remain landmarks in neurochemical research.image
Anatomical design and production of a novel three‐dimensional co‐culture system replicating the human flexor digitorum profundus enthesis
Authors: Mortimer Jeremy W. , Rust Philippa A. , Paxton Jennifer Z. 
Published: February 2024

AbstractThe enthesis, the specialized junction between tendon and bone, is a common site of injury. Although notoriously difficult to repair, advances in interfacial tissue engineering techniques are being developed for restorative function. Most notably are 3D in vitro co‐culture models, built to recreate the complex heterogeneity of the native enthesis. While cell and matrix properties are often considered, there has been little attention given to native enthesis anatomical morphometrics and replicating these to enhance clinical relevance. This study focuses on the flexor digitorum profundus (FDP) tendon enthesis and, by combining anatomical morphometrics with computer‐aided design, demonstrates the design and construction of an accurate and scalable model of the FDP enthesis. Bespoke 3D‐printed mould inserts were fabricated based on the size, shape and insertion angle of the FDP enthesis. Then, silicone culture moulds were created, enabling the production of bespoke anatomical culture zones for an in vitro FDP enthesis model. The validity of the model has been confirmed using brushite cement scaffolds seeded with osteoblasts (bone) and fibrin hydrogel scaffolds seeded with fibroblasts (tendon) in individual studies with cells from either human or rat origin. This novel approach allows a bespoke anatomical design for enthesis repair and should be applied to future studies in this area.
Formulation and evaluation of antioxidant and antibacterial activity of a peel‐off facial masks moisturizer containing curcumin andRosa Damascenaextract
Authors: Nemati Mohammad Mehdi , Abedi Mehdi , Ghasemi Younes , Ashrafi Hajar , Haghdel Mobin 
Published: February 2024

AbstractBackgroundAcne is a common skin issue that typically occurs during adolescence. It causes long‐lasting redness and swelling in the skin. An alternative approach to treating acne could involve using a cosmetic facial mask containing herbal ingredients such as Curcumin andRosa Damascenaextract for its antibacterial properties.AimsThis study aims to create and try out a peel‐off mask gel made from Curcumin andR. Damascenaextract. This gel is intended to have the ability to kill bacteria such asStaphylococcus aureus,Escherichia coli, andPropionibacterium acnesand remove dead cells from the skin surface.MethodsThe peel‐off mask was made using polyvinyl alcohol (PVA) in 8% and 10% as solidifier. The evaluation of peel‐off masks comprises the examination of physiochemical and mechanical aspects. Furthermore, their longevity, effectiveness, and antibacterial properties are also considered.ResultsThe white color, pleasant smell, and soft texture were the defining features of the peel‐off gel mask. The changes in PVA affect the pH level, thickness, and how quickly the peel‐off mask dries. The stability test found that the peel‐off mask had no significant physical changes when exposed to freezing and thawing. However, there were some differences in color and separation when using the real‐time method. A prepared peel‐off mask containing 10% PVA and curcumin works best againstP. acne. The amount of PVA in the formula affected the physical and chemical qualities, but it did not impact on the antibacterial abilities of the peel‐off mask gel. The best formula that gives the best results uses 10% PVA + curcumin.ConclusionsUsing the Curcumin andR. Damascenaextract in the creation of the peel‐off mask gel ensures its efficacy and safety for skin application.
Early Acquaintances with Modern Mass Culture in Late Ottoman Istanbul: The Experiences of Child Audiences at Direklerarası
Authors: Tunç Yaşar Fatma , Ayas Onur Güneş 
Published: February 2024

AbstractDireklerarası, the core of Ramadan entertainment in late Ottoman Istanbul, rose to prominence toward the end of the nineteenth century at about the same time as entertainment hubs in Paris, Berlin, Tokyo, and New York. Thanks to the legitimacy provided by the Holy Ramadan, which played a positive role in reducing public suspicion and uneasiness among Muslim families towards the products of early mass culture, Direklerarası seems to draw a larger children's audience compared to Pera and Galata, the epicenter of European‐style entertainment and a location where non‐Muslims were heavily populated. As a result, many children were introduced to emerging modern mass culture at Direklerarası, which offers a large variety of shows and spectacles grouped under the name of lubiyat in the Ottoman world, including theater, musical plays, juggling, circus, concerts, shadow theater and cinema. This article focuses on childhood experiences at Direklerarası using a wide range of primary sources from archival documents and official regulations to Ottoman periodicals and memoirs. It aims to discuss the moral and aesthetic concerns arising from the fact that the spheres of adults and children were not yet clearly separated from each other, as well as how this experience at Direklerarası was remembered later as a childhood memory.
Returning to work after lockdown: A multi‐study investigation into the temporal effects of directive leadership
Authors: Gao Zhonghua , Liu Yonghong , Chuang Aichia , Zhou Jinlai , Zhao Chen , Yang Jun 
Published: February 2024

AbstractLeaders' use of directive leadership has been found to increase when they face an unprecedented crisis. However, extant literature has failed to answer how directive leadership functions in this specific situation. Using the return‐to‐work after COVID‐19 lockdown as an example, we drew upon regulatory focus theory and conducted three studies to investigate the temporal effects of directive leadership on followers' regulatory foci and work role performance. In Study 1, we conducted an experience sampling method (ESM) study tracking a sample of 250 employees over 1 week when the COVID‐19 was originally reported in China. In Study 2, we conducted another ESM study on 125 employees over 2 weeks when the Omicron variant was surging in China. Both studies showed that the positive effect of daily directive leadership on followers' work promotion focus was strongest on the first day upon returning to work after lockdowns but decreased over time. In contrast, the positive effect of daily directive leadership on followers' work prevention focus increased throughout our sampling periods and became strongest on the last day. Moreover, our results indicate that daily directive leadership interacts with the elapsed time to influence two forms of work role performance – task proactivity and task proficiency – through the mediating roles of promotion focus and prevention focus, respectively. In Study 3, we conducted a vignette experiment employing a within‐ and between‐subject design on a sample of 171 U.S. participants. The results further supported the moderating role of elapsed time after returning to work in the differential effects of directive leadership on followers' two regulatory foci.
Comparison of solubility profiles for pioneer and generic monensin premixes in biorelevant simulated intestinal fluid based on shake flask extractions
Authors: Krabel Beverly J. , Foust Laura B. , Fuller Gary B. , Hunter Robert P. 
Published: February 2024

AbstractIn the United States, a generic Type A medicated article product can gain the FDA approval by demonstrating bioequivalence (BE) to the pioneer product by successfully conducting a blood level, pharmacodynamic, or clinical BE study. A biowaiver can be granted based on several criteria, assuming the dissolution of the test and reference products represents the only factor influencing the relative bioavailability of both products. Monensin is practically insoluble in H2O per the USP definition. Previously published data from a comparison study of monensin dissolution profiles from the pioneer product and four generic products using biorelevant media showed that generic monensin products demonstrated different dissolution profiles to the pioneer product in these USP biorelevant rumen media. This follow‐up study compared the solubility profiles in simulated intestinal fluid (cFaSSIF, pH 7.5) for the pioneer product and four generic products. The generic monensin products demonstrated different in vitro dissolution profiles to the pioneer product in biorelevant media. The differences demonstrated in solubility and dissolution profiles are of concern regarding the potential efficacy of generic monensin in cattle. There are also additional concerns for the potential development of Eimeria resistance in cattle receiving a sub‐therapeutic dose of monensin from a less soluble generic product.
From the rotting soil grows the poison ivy: The Supreme Court and the legitimation of Herrenvolk democracy
Authors: Novkov Julie 
Published: February 2024

AbstractIn recent years, the Court has swung sharply to the right but has thus far declined to support the most antidemocratic and radically authoritarian agendas of the Trumpist wing of the Republican Party. While scholars and concerned Americans have focused on the visible things the Court is dismantling and fretted about its potential for enhancing constitutional rot, this article sketches out what the Court is building. It illustrates that this constructive process is distinctive not just in its political and partisan orientation but also in the Court's capacity to achieve it. Considering the emerging product of its recent jurisprudence suggests an embrace of a narrowed form of democracy that empowers a subset of political actors to build their idealized visions of the state, primarily at the subnational level.
Critical literacies in algorithmic cultures
Authors: Ehret Christian 
Published: February 2024

AbstractA shift in primacy from online participatory cultures to algorithmic cultures invites new questions about literacies in digital contexts. This article contributes to the conceptualisation of literacies in algorithmic cultures through sociomaterial and affect theories. It develops a sociomaterial perspective that proposes felt, observable moments of user–algorithmic co‐productions of culture as a needed unit of analysis for researching contemporary, critical digital literacies. It then employs this unit as a starting point for analysing the interplay of feeling, critical reflection and algorithm agency across one young adult's self‐described literacy practice of ‘working algorithms’ across social media platforms. Analysis illustrates how critical literacies in algorithmic cultures are driven by processes of human–machine feeling–thinking that cannot be reduced to rational critiques of ideologies, platform capitalism or other forms of power alone. It describes how Malaya became more attuned over time to the affects of working with platform algorithms to craft her community, her sense of self and her sense of well‐being. This sensitivity to feeling moved and feeling the capacity to move machines through the use of her literacies highlights how the facilitation of affect is a crucial point of analysis in understanding contemporary digital literacies.
Overcoming the egress block of Plasmodium sporozoites expressing fluorescently tagged circumsporozoite protein
Authors: Thieleke‐Matos Carolina , Walz Kevin , Frischknecht Friedrich , Singer Mirko 
Published: February 2024

AbstractPlasmodium sporozoites are the highly motile and invasive forms of the malaria parasite transmitted by mosquitoes. Sporozoites form within oocysts at the midgut wall of the mosquito, egress from oocysts and enter salivary glands prior to transmission. The GPI‐anchored major surface protein, the circumsporozoite protein (CSP) is important for Plasmodium sporozoite formation, egress, migration and invasion. To visualize CSP, we previously generated full‐length versions of CSP internally tagged with the green fluorescent protein, GFP. However, while these allowed for imaging of sporogony in oocysts, sporozoites failed to egress. Here, we explore different strategies to overcome this block in egress and obtain salivary gland resident sporozoites that express CSP‐GFP. Replacing the N‐terminal and repeat region with GFP did not allow sporozoite formation. Lowering expression of CSP‐GFP at the endogenous locus allowed sporozoite formation but did not overcome egress block. Crossing of CSP‐GFP expressing parasites that are blocked in egress with wild‐type parasites yielded a small fraction of parasites that entered salivary glands and expressed various levels of CSP‐GFP. Expressing CSP‐GFP constructs from a silent chromosome region from promoters that are active only post salivary gland invasion yielded normal numbers of fluorescent salivary gland sporozoites, albeit with low levels of fluorescence. We also show that lowering CSP expression by 50% allowed egress from oocysts but not salivary gland entry. In conclusion, Plasmodium berghei parasites with normal CSP expression tolerate a certain level of CSP‐GFP without disruption of oocyst egress and salivary gland invasion.
Terbinafine resistance in Trichophyton mentagrophytes and Trichophyton rubrum in the Czech Republic: A prospective multicentric study
Authors: Kolarczyková Daniela , Lysková Pavlína , Švarcová Michaela , Kuklová Ivana , Dobiáš Radim , Mallátová Naďa , Kolařík Miroslav , Hubka Vit 
Published: February 2024

AbstractBackgroundTerbinafine, an allylamine antifungal, is crucial for treating dermatophytosis by inhibiting squalene epoxidase (SQLE) in the ergosterol biosynthetic pathway. However, resistance is emerging, particularly in India and Southeast Asia, but reports of resistance spread worldwide. Despite this, comprehensive studies on terbinafine resistance in Trichophyton are still limited.ObjectivesThis research aimed to determine the prevalence of terbinafine resistance in the Czech Republic, with a focus on Trichophyton rubrum and Trichophyton mentagrophytes, and investigate the underlying molecular mechanisms.Patients/MethodsA total of 514 clinical strains of T. rubrum and 240 T. mentagrophytes collected from four Czech clinical institutions were screened for terbinafine resistance. Molecular investigations included DNA sequencing, specifically the ITS rDNA region and SQLE gene, as well as antifungal susceptibility testing following EUCAST guidelines.ResultsWhile no resistance was observed in T. rubrum, 2.5% of T. mentagrophytes strains exhibited resistance, marked by the F397L mutation in SQLE. Notably, resistance surged from 1.2% in 2019 to 9.3% in 2020 but reverted to 0% in 2021. All resistant strains were identified as T. mentagrophytes var. indotineae. Resistant strains exhibited high MICs for terbinafine (≥4 mg L−1) but low MICs to the other seven antifungals tested except for fluconazole.ConclusionsThis study highlights the emergence of terbinafine‐resistant T. mentagrophytes strains in the Czech Republic, with the F397L mutation being pivotal. Due to the relatively low resistance level, the current guidelines for dermatomycosis treatment in the Czech Republic remain effective, but ongoing surveillance is essential for timely adaptations if resistance patterns change.
Consensus statement on the management of hyperkalaemia—AnAsia–Pacificperspective
Authors: Yap Desmond Y. H. , Ma Ronald C. W. , Wong Emmanuel C. K. , Tsui Matthew S. H. , Yu Esther Y. T. , Yu Vivien , Szeto Cheuk Chun , Pang Wing Fai , Tse Hung Fat , Siu David C. W. , Tan Kathryn C. B. , Chen Walter W. C. , Li Chiu Leong , Chen Wei , Chan Tak Mao 
Published: February 2024

AbstractHyperkalaemia is an electrolyte imbalance that impairs muscle function and myocardial excitability, and can potentially lead to fatal arrhythmias and sudden cardiac death. The prevalence of hyperkalaemia is estimated to be 6%–7% worldwide and 7%–10% in Asia. Hyperkalaemia frequently affects patients with chronic kidney disease, heart failure, and diabetes mellitus, particularly those receiving treatment with renin‐angiotensin‐aldosterone system (RAAS) inhibitors. Both hyperkalaemia and interruption of RAAS inhibitor therapy are associated with increased risks for cardiovascular events, hospitalisations, and death, highlighting a clinical dilemma in high‐risk patients. Conventional potassium‐binding resins are widely used for the treatment of hyperkalaemia; however, caveats such as the unpalatable taste and the risk of gastrointestinal side effects limit their chronic use. Recent evidence suggests that, with a rapid onset of action and improved gastrointestinal tolerability, novel oral potassium binders (e.g., patiromer and sodium zirconium cyclosilicate) are alternative treatment options for both acute and chronic hyperkalaemia. To optimise the care for patients with hyperkalaemia in the Asia–Pacific region, a multidisciplinary expert panel was convened to review published literature, share clinical experiences, and ultimately formulate 25 consensus statements, covering three clinical areas: (i) risk factors of hyperkalaemia and risk stratification in susceptible patients; (ii) prevention of hyperkalaemia for at‐risk individuals; and (iii) correction of hyperkalaemia for at‐risk individuals with cardiorenal disease. These statements were expected to serve as useful guidance in the management of hyperkalaemia for health care providers in the region.image
Pre‐operative colour Doppler ultrasound for the prevention of bleeding complications after renal biopsy: A rare case of left renal lower pole vein
Authors: Kawaguchi Azusa , Kimura Ryoma , Araki Yoshinori 
Published: February 2024

AbstractAlbeit rare, renal vein abnormalities on autopsy and in cases of abdominal surgery complications have been reported and should be kept in mind when performing invasive procedures, such as renal biopsy. We detected a rare renal vein abnormality on colour Doppler ultrasound before renal biopsy, thereby, avoiding a haemorrhagic complication. A 10‐year‐old boy presented to our department for the first time because of incidental findings of haematuria and proteinuria. We suspected chronic glomerulonephritis and scheduled an ultrasound‐guided percutaneous renal biopsy. A simple screening ultrasound at the initial visit revealed no renal or vascular abnormalities. The day before the renal biopsy, we confirmed the biopsy site by performing a colour Doppler ultrasound, which showed abnormal blood flow from the lower pole of the left kidney, which was the planned puncture site; therefore, we changed the biopsy site to the right and completed the examination. Subsequent computed tomography angiography depicted two renal veins; one was the usual left renal vein draining from the kidney hilum, and the second was an accessory vein draining from the inferior pole of the left kidney and entering the inferior vena cava through the dorsal side of the aorta. Although rare, abnormalities in the renal vessels on the inferior pole of the kidney, which is the usual site of renal biopsy, are essential to rule out preoperatively by colour Doppler ultrasound, because these can cause significant bleeding during renal biopsy if not recognized.
Latent profile analysis reveals the central role of psychological symptoms in driving disease severity in chronic constipation
Authors: Abber Sophie R. , Buchanan Kelly L. , Clukey Jenna , Joiner Thomas E. , Staller Kyle , Burton‐Murray Helen 
Published: February 2024

AbstractBackgroundChronic constipation (CC) is defined by symptom criteria reflecting heterogenous physiology. However, many patients with CC have significant psychological comorbidities—an alternative definition using a biopsychosocial classification model could be warranted to inform future treatments. We sought to: (1) empirically derive psychological symptom profiles of patients with CC using latent profile analysis and (2) validate these profiles by comparing them on symptom severity, GI‐specific anxiety, body mass index (BMI), and anorectal manometry findings.MethodsParticipants included adults presenting for anorectal manometry for CC (N = 468, 82% female, Mage = 47). Depression/anxiety symptoms and eating disorder (ED) symptoms (EAT‐26) were used as indicators (i.e., variables used to derive profiles) representing unique psychological constructs. Constipation symptoms, GI‐specific anxiety, BMI, and anorectal manometry results were used as validators (i.e., variables used to examine the clinical utility of the resulting profiles).Key ResultsA 5‐profile solution provided the best statistical fit, comprising the following latent profiles (LPs): LP1 termed “high dieting, low bulimia;” LP2 termed “high ED symptoms;” LP3 termed “moderate ED symptoms;” LP4 termed “high anxiety and depression, low ED symptoms;” and LP5 termed “low psychological symptoms.” The low psychological symptom profile (61% of the sample) had lower abdominal and overall constipation severity and lower GI‐specific anxiety compared to the four profiles characterized by higher psychological symptoms (of any type). Profiles did not significantly differ on BMI or anorectal manometry results.Conclusions and InferencesProfiles with high psychological symptoms had increased constipation symptom severity and GI‐specific anxiety in adults with CC. Future research should test whether these profiles predict differential treatment outcomes.
Multivariate Trend‐Cycle‐Seasonal Decompositions with Correlated Innovations*
Authors: Tian Jing , Jacobs Jan P.A.M. , Osborn Denise R. 
Published: February 2024

AbstractMultivariate analysis can help to focus on important phenomena, including trend and cyclical movements, but any economic information in seasonality is typically ignored. The present paper aims to more fully exploit time series information through a multivariate unobserved component model for quarterly data that exhibits seasonality together with cross‐variable component correlations. We show that economic restrictions, including common trends, common cycles and common seasonals can aid identification. The approach is illustrated using Italian GDP and consumption data.