bluuebunny/crossref_metadata_2025_split huggingface dataset:
Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells
Authors: Cottrell Kyle A. , Ryu Sua , Pierce Jackson R. , Soto Torres Luisangely , Bohlin Holly E. , Schab Angela M. , Weber Jason D. 
Published: March 2024

Abstract

Detection of viral double-stranded RNA (dsRNA) is an important component of innate immunity. However, many endogenous RNAs containing double-stranded regions can be misrecognized and activate innate immunity. The IFN-inducible ADAR1-p150 suppresses dsRNA sensing, an essential function for adenosine deaminase acting on RNA 1 (ADAR1) in many cancers, including breast. Although ADAR1-p150 has been well established in this role, the functions of the constitutively expressed ADAR1-p110 isoform are less understood. We used proximity labeling to identify putative ADAR1-p110–interacting proteins in breast cancer cell lines. Of the proteins identified, the RNA helicase DHX9 was of particular interest. Knockdown of DHX9 in ADAR1-dependent cell lines caused cell death and activation of the dsRNA sensor PKR. In ADAR1-independent cell lines, combined knockdown of DHX9 and ADAR1, but neither alone, caused activation of multiple dsRNA sensing pathways leading to a viral mimicry phenotype. Together, these results reveal an important role for DHX9 in suppressing dsRNA sensing by multiple pathways.

Significance:
These findings implicate DHX9 as a suppressor of dsRNA sensing. In some cell lines, loss of DHX9 alone is sufficient to cause activation of dsRNA sensing pathways, while in other cell lines DHX9 functions redundantly with ADAR1 to suppress pathway activation.
Error-based Implicit Learning in Language: The Effect of Sentence Context and Constraint in a Repetition Paradigm
Authors: Hodapp Alice , Rabovsky Milena 
Published: March 2024

Abstract
Prediction errors drive implicit learning in language, but the specific mechanisms underlying these effects remain debated. This issue was addressed in an EEG study manipulating the context of a repeated unpredictable word (repetition of the complete sentence or repetition of the word in a new sentence context) and sentence constraint. For the manipulation of sentence constraint, unexpected words were presented either in high-constraint (eliciting a precise prediction) or low-constraint sentences (not eliciting any specific prediction). Repetition-induced reduction of N400 amplitudes and of power in the alpha/beta frequency band was larger for words repeated with their sentence context as compared with words repeated in a new low-constraint context, suggesting that implicit learning happens not only at the level of individual items but additionally improves sentence-based predictions. These processing benefits for repeated sentences did not differ between constraint conditions, suggesting that sentence-based prediction update might be proportional to the amount of unpredicted semantic information, rather than to the precision of the prediction that was violated. In addition, the consequences of high-constraint prediction violations, as reflected in a frontal positivity and increased theta band power, were reduced with repetition. Overall, our findings suggest a powerful and specific adaptation mechanism that allows the language system to quickly adapt its predictions when unexpected semantic information is processed, irrespective of sentence constraint, and to reduce potential costs of strong predictions that were violated.
Evaluation of Point-to-Point Reaching Performance in Mixed Reality and Virtual Reality
Authors: Petrie Tyler G. , Zhao Chen , Fu Michael J. 
Published: March 2024

Abstract
Recent immersive mixed reality (MR) and virtual reality (VR) displays enable users to use their hands to interact with both veridical and virtual environments simultaneously. Therefore, it becomes important to understand the performance of human hand-reaching movement in MR. Studies have shown that different virtual environment visualization modalities can affect point-to-point reaching performance using a stylus, but it is not yet known if these effects translate to direct human-hand interactions in mixed reality. This paper focuses on evaluating human point-to-point motor performance in MR and VR for both finger-pointing and cup-placement tasks. Six performance measures relevant to haptic interface design were measured for both tasks under several different visualization conditions (“MR with indicator,” “MR without indicator,” and “VR”) to determine what factors contribute to hand-reaching performance. A key finding was evidence of a trade-off between reaching “motion confidence” measures (indicated by throughput, number of corrective movements, and peak velocity) and “accuracy” measures (indicated by end-point error and initial movement error). Specifically, we observed that participants tended to be more confident in the “MR without Indicator” condition for finger-pointing tasks. These results contribute critical knowledge to inform the design of VR/MR interfaces based on the application's user performance requirements.
Bridging the Headset: Engagement, Collaboration, and Learning in and around Virtual Reality
Authors: Tärning Betty , Gulz Agneta , Nirme Jens 
Published: March 2024

Abstract
To study engagement and learning, we developed an asymmetric collaborative version of an existing VR-experience about environmental sustainability, enabling student teams of three, with only one wearing a headset at any time, to collaborate in three different virtual reality subgames. We compared this collaborative version to a non-collaborative version in a between-subjects experimental study (n = 20), finding that student teams using the collaborative version interacted to a larger extent while performing the subgames. The students in these teams self-reported a higher level of engagement, and observations suggested that interactions extended beyond necessary instructions. We did not find any significant differences when it comes to learning measured by scores on pre- and post-knowledge tests, but quantitative analysis of responses indicates that the VR-experience affected students overall and a qualitative analysis of an open question suggested a particular effect on the collaborative teams. Logged performance data indicated that collaborative teams managed to solve the tasks involved in the subgames at least as efficiently as the teams using the non-collaborative version.
What’s Cooking? General Measures in the Case Law of the European Court of Human Rights
Authors: Popelier Patricia 
Published: March 2024

Abstract
Strategic deference is used by the European Court of Human Rights (Court) to keep the United Kingdom on board. This can be explained as a means to address autocratic strategies, but is harder to justify where it differentiates between consolidated democracies. To preserve authority and credibility, the Court must maintain an appearance of consistency. To this end, the ‘procedural turn’ in the Court’s case law has been presented as a development of the subsidiarity principle, consistent with earlier case law. In this paper, however, the case is made that procedural arguments are used (or avoided) in fundamentally different ways, reflecting very different mindsets. The paper distinguishes six approaches to so-called ‘general measures’ and explains in each case the underlying attitude towards national member states. By lumping them all together, strategic deference is concealed, allowing for a more favourable treatment of the UK while keeping up appearances that all contracting parties are treated alike.
Investigating Differences between Tropical Cyclone Detection Systems
Authors: Galea Daniel , Hodges Kevin , Lawrence Bryan N. 
Published: March 2024

Abstract
Tropical cyclones (TCs) are important phenomena, and understanding their behavior requires being able to detect their presence in simulations. Detection algorithms vary; here we compare a novel deep learning–based detection algorithm (TCDetect) with a state-of-the-art tracking system (TRACK) and an observational dataset (IBTrACS) to provide context for potential use in climate simulations. Previous work has shown that TCDetect has good recall, particularly for hurricane-strength events. The primary question addressed here is to what extent the structure of the systems plays a part in detection. To compare with observations of TCs, it is necessary to apply detection techniques to reanalysis. For this purpose, we use ERA-Interim, and a key part of the comparison is the recognition that ERA-Interim itself does not fully reflect the observations. Despite that limitation, both TCDetect and TRACK applied to ERA-Interim mostly agree with each other. Also, when considering only hurricane-strength TCs, TCDetect and TRACK correspond well to the TC observations from IBTrACS. Like TRACK, TCDetect has good recall for strong systems; however, it finds a significant number of false positives associated with weaker TCs (i.e., events detected as having hurricane strength but are weaker in reality) and extratropical storms. Because TCDetect was not trained to locate TCs, a post hoc method to perform comparisons was used. Although this method was not always successful, some success in matching tracks and events in physical space was also achieved. The analysis of matches suggested that the best results were found in the Northern Hemisphere and that in most regions the detections followed the same patterns in time no matter which detection method was used.
Suppressive MJO in April 2014 Downgraded the 2014/15 El Niño
Authors: Wang Jie , Chen Dake , Lian Tao , Li Baosheng , Han Xiang , Liu Ting 
Published: March 2024

Abstract
The sudden halting of the extreme 2014/15 El Niño expected by many was attributed to the absence of westerly wind bursts (WWBs) in late spring and early summer 2014 in previous works, yet the cause of the lack of WWBs was overlooked. Using the ERA5 reanalysis and IBTrACS dataset, as well as a set of coupled model experiments, we showed that the absence of WWBs in May efficiently downgraded the intensity of the 2014/15 El Niño from a moderate to a weak event and was closely associated with a strong suppressive MJO originating from the central tropical Indian Ocean in mid-April 2014. The suppressive MJO underwent two pathways once passing through the Maritime Continent in early May. Along the eastward pathway, the strong suppressive MJO prevailed over the western–central equatorial Pacific, directly prohibiting the occurrence of WWBs at the equator via inducing equatorial easterly anomaly. Along the northeastward pathway, the downward motions with relative dry air and strong vertical zonal wind shear associated with the suppressive MJO suppressed the activity of the tropical cyclones in the northwestern tropical Pacific, another source of WWBs. Our results indicate that the contributions of MJO to the development of El Niño from both the direct and indirect ways should be taken into account for improving El Niño prediction.
Strengthened Combined Impact of the Pacific and Atlantic Meridional Modes on Eastern North Pacific Tropical Cyclones since the 1990s
Authors: Sun Qi , Zhao Haikun , Klotzbach Philip J. , Han Xiang , Gao Jun , Wu Jin , Ma Zhanhong 
Published: March 2024

Abstract
There has been increased focus in recent years on the impact of the Pacific meridional mode (PMM) and the Atlantic meridional mode (AMM) on weather and climate events. This study shows an increased synergistic impact of both the PMM and AMM on eastern North Pacific (ENP) extended boreal summer (June–November) tropical cyclone frequency (TCF) since the 1990s. This increase in the combined impact of both the PMM and AMM on ENP TCF is mainly due to a stronger modulation of the AMM on TCF since the early 1990s and of a stronger modulation of the PMM on TCF since the late 1990s. A budget analysis of the genesis potential index highlights the important contribution of changes in vertical wind shear to the recent strengthened AMM–TCF relationship, while potential intensity and vertical wind shear are the two most important drivers of the recent increase in the PMM–TCF relationship. This intensified association is largely explained by changes in the mean state of sea surface temperatures in the tropical Atlantic associated with the Atlantic multidecadal oscillation (AMO) and trade wind magnitude in the subtropical Pacific Ocean associated with the Pacific decadal oscillation (PDO). This study highlights an asymmetric effect of the AMO and PDO on these two meridional modes and ENP TC genesis frequency and provides a better understanding of ENP TC activity on interannual-to-decadal time scales.
The Role of Social Cognition in Depression and Its Relationship to Early Maladaptive Schemas
Authors: Ghosh Debaleena , Halder Susmita 
Published: March 2024

Background: Social cognition is the capacity to detect, comprehend, and evaluate environmentally relevant information and serves as a critical skill for effective interpersonal functioning. A significant clinical characteristic of depressive illness is the impairment in social and interpersonal functioning. Given the increasing prevalence of interpersonal difficulties among individuals with depression, it is crucial to get a greater insight into the underlying cognitive mechanisms leading to these social deficits. Alongside, early maladaptive schemas (EMS) also serve as proximal cognitive risk factors for depression. Altered socio-cognitive functioning in individuals with can help to draw a connection between impaired social cognition and EMS. In this context, the present study explores the role of social cognition in individuals with depression in relation to EMS. Methods: In this study, individuals of both genders ( N = 60) were pooled based on the inclusion and exclusion criteria and screened for depression through the Beck Depression Inventory. Emotion Recognition and Theory of Mind (ToM) were assessed using the Reading Mind in the Eyes Test (RMET) and Theory of Mind Assessment Scale (TH.O.M.A.S), respectively. EMS was assessed using the Young Schema Questionnaire-Short Form. Results: Results indicate individuals with depression were found to be impaired in both domains of social cognition-emotion recognition and ToM. Individuals with depression also exhibited a greater number of EMS. A significant association was found between EMS and social cognition in depression. Moreover, few of the EMS emerged as significant predictors for social cognition in depression. Conclusion: Individuals with depression exhibit impairment in “reading” social interactions. Moreover, they exhibit specific EMS that emerges as significant predictors of social cognition. Implications of the study focus on recognizing EMS as a tool for addressing the socio-cognitive impairment in depression.
Associations Between Both Adaptive and Maladaptive Personality Constructs and Emotional Load and Content of Adult Dreams
Authors: Komasi Saeid , Nazari Amin , Faridmarandi Behrooz , Saeidi Mozhgan , Bahremand Mostafa , Shadman Taherh , Mirani Atefeh , Nazarpour Parisa , Kiani Zhaleh , Zakiei Ali 
Published: March 2024

Background: It seems that personality and dreams are relatively stable interwoven constructs that show many shared characteristics across cultures. The present study aimed to predict the emotional load and content of dreams using both original constructs and two extracted spectrum factors of adaptive and maladaptive personalities. Methods: The cross-sectional study data was collected from 704 Iranian adults using the brief version of the Personality Inventory for DSM-5, the brief version of the Big Five Inventory, Schredl’s Dream Emotions Manual, and the Content Analysis of Dreams Manual. Pearson correlations, hierarchical regressions, exploratory factor analysis, and analysis of variance were used to analyse the data. Results: Factor analysis revealed two factors for the adaptive and maladaptive spectrums of personality. Adaptive and maladaptive constructs of personality are almost equally related to both the negative and positive loads of dreams, while the negative load of dreams is more strongly predicted by the maladaptive spectrum factor ( R2: 13% vs. 7%, ∆ R2: 8% vs. 2%). Negative load is characterized by low agreeableness and high negative affectivity, while positive load is characterized by high agreeableness and low detachment. Compared to most negative dream content such as distress, dreamers with happy content reported higher adaptive traits and lower maladaptive traits. Conclusions: The emotional load and content of dreams are significantly related to both specific constructs and spectrum factors of adaptive and maladaptive personalities. Psychologists can refer to personality profiles when analysing the emotional load and content of dreams of adults.
Mental Health Insurance in India: An Examination of Policy Implementation Post-MHCA 2017
Authors: Avula Vijaya Chandra Reddy , Godi Sangha Mitra , Munivenkatappa Shashidhara , Amalakanti Sridhar 
Published: March 2024

Purpose of review: Owing to the high cost of care and huge treatment gap associated with mental illnesses in India, this review investigated the implementation of mental health insurance coverage in India following the mandate of the Mental Health Care Act of 2017 (MHCA 2017). Collection and analysis of data: We systematically identified health insurance providers in India through the Insurance Regulatory and Development Authority of India (IRDAI) website. We meticulously searched and obtained policy documents from either the IRDAI website or the respective insurance company websites. Our classification process involved determining if a policy explicitly covered mental illness, which we discerned by examining definitions of mental illness, indemnification clauses or the presence of International Classification of Diseases-10 codes within the policy. Conclusion: We evaluated 235 policies provided by 30 insurance companies and found that 37.5% (88) of policies covered mental illnesses, 11.5% (28) covered persons with disabilities, whereas 51% (119) did not offer any coverage. The majority of the companies did not cover suicide and substance use disorders. There are disparities in the outpatient care offerings, including extended waiting periods for coverage of mental illness.  This review highlights the importance of aligning insurance practices with MHCA 2017s provisions to promote mental health equity in India. It also advocates for comprehensive mental health coverage that includes outpatient care, substance use disorders and suicide as well as a need for standardized definitions and transparent policy communication.
The Knight in Shining Armour: JSW Steel Ltd’s Acquisition of Bhushan Power and Steel Ltd
Authors: Mistry Janki 
Published: March 2024

This case revolves around the acquisition of Bhushan Power and Steel Ltd (BPSL) by JSW Steel Ltd BPSL faced severe financial difficulties, prompting its lenders, including prominent Indian banks, to initiate insolvency proceedings under Section 7 of the Insolvency and Bankruptcy Code in 2019. JSW Steel Ltd entered the competition to acquire BPSL’s assets and secured the bid. However, complications arose as the Enforcement Directorate and BPSL’s promoters raised objections, leading to delays in the insolvency process. The case spotlights a significant Indian corporate reform represented by the Insolvency and Bankruptcy Code and the establishment of the National Company Law Appellate Tribunal (NCLAT). This reform proved essential as it provided an alternative to distressed companies, which previously had no choice but to cease operations, adversely affecting both employees and lenders. The NCLAT has since introduced a win-win solution for most stakeholders. Furthermore, the case delves into the crucial characteristics of the steel industry, an indispensable product utilized across various global industries, and how these features significantly impact strategic decision-making. It underscores the strategic value of JSW Steel Ltd’s acquisition of a struggling company. In summary, it offers a comprehensive perspective on the insolvency process, the roles of the NCLAT and Enforcement Directorate, and the value generated through the acquisition.
Oyo Hotel’s Expansion Spree: Too Much, Too Fast?
Authors: Bhattacharya Arijit 
Published: March 2024

Established in 2013, Oyo Hotels & Rooms, an Internet startup in the Indian hospitality sector, experienced an astonishing journey, culminating in a valuation of USD 5 billion by the end of 2018. The remarkable success of Oyo left many observers astounded. This meteoric rise was attributed to Oyo’s innovative business model, strategically targeting the fragmented budget segment of hotels beset by inefficiency. Oyo addressed these challenges by providing access to hotel rooms in prime locations, ensuring standardized services and offering affordability to customers. Over the years, Oyo gradually diverged from its core business as a mere aggregator of hotel rooms. It ventured into leasing hotels in the mid and premium segments, tapped into the Indian wedding segment, acquired companies and expanded its footprint into numerous foreign markets. This case aims to scrutinize whether this accelerated growth strategy could compromise the fundamental service promise of standardization. Additionally, it investigates whether the financially robust company, particularly after securing a USD 1 billion investment in September 2018, risks losing touch with reality as it becomes entangled in various controversies.
Increased symptoms of stiffness after opening-wedge high tibial osteotomy are associated with worse postoperative knee function outcomes and lower patient satisfaction rate
Authors: Yu Jiahao , Song Bixuan , Zhu Yanbin , Wang Juan , Zhang Yingze 
Published: March 2024

Background Symptoms of knee stiffness after open wedge high tibial osteotomy (OW-HTO) can significantly affect surgical effectiveness, but no studies have reported risk factors for knee stiffness after OW-HTO. Methods Patients treated with OW-HTO for the first time between 2018 and 2021 were included. Data were collected on patient demographics, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Short Form (SF) 12 scores, hip-knee-ankle angle (HKA) and patient satisfaction before and after surgery. Patients with worse WOMAC stiffness scores at 1 year were defined as the 'increased stiffness' group and the other cohort as the 'non-stiffness' group. The primary outcome of the study was to compare postoperative knee function scores (WOMAC and SF-12), HKA and patient satisfaction rate between the two groups. The secondary outcome was the use of logistic regression to analyze independent predictors of increased postoperative stiffness symptoms. Results At 1 year postoperatively, 95 (11.3%) patients had a significant increase in stiffness. Patients had significantly ( p < .001) less improvement in pain, function, and total WOMAC scores, and SF-12 score than those in the non-stiffness group ( n = 745). However, the differences in WOMAC and SF-12 scores in increased stiffness group at 1 year post-operatively were statistically significant ( p < .001) compared to the non-stiffness group. There was no statistically significant difference in HKA in the increased stiffness group (172.9° ± 2.3°) compared to non-stiffness group (173.4° ± 2.6°) at 1 year postoperatively ( p = .068). Patient satisfaction was significantly lower in the increased stiffness group ( p < .001). Logistic regression analysis showed that diabetes (odds ratio (OR) 1.809, p = .034) and preoperative WOMAC stiffness score of 44 or less (OR 4.255 p < .001) were predictors of increased stiffness. Conclusions Patients with increased stiffness after OW-HTO had worse functional outcomes and lower patient satisfaction rates and patients at risk of being in this group should be informed pre-operatively.