bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing quality of life in head and neck cancer patients: a comparative analysis of 3D exoscope-assisted surgery vs. traditional approaches
Authors: Marchi Filippo , Bellini Elisa , Ioppi Alessandro , Simoni Federica , Iandelli Andrea , Filauro Marta , Mora Francesco , Sampieri Claudio , Peretti Giorgio 
Published: April 2024

IntroductionThe increasing population of survivors of head and neck carcinomas is becoming more conspicuous. Consequently, the pivotal role of quality of life, particularly elucidated through the assessment of dysphagia and dysphonia, is progressively influencing the decision-making process. The current study aims to assess whether VITOM 3D could offer a comparable post-treatment quality of life to traditional approaches for patients with laryngeal cancer and oro-hypopharyngeal cancer.MethodsA case series of laryngeal cancer and oro-hypopharyngeal cancer patients treated either with an exoscopic-assisted surgical setup and with conventional treatments (transoral microsurgery and radio-chemotherapy) at the Otolaryngology Unit of IRCCS San Martino Hospital, Genoa, is presented. The post-treatment quality of life of the two cohorts were compared through the administration of the University of Washington Quality of Life Questionnaire, Voiceik Handicap Index-10, M.D. Anderson Dysphagia Inventory were administrated to both cohorts of patients.ResultsIn the laryngeal cancer group, a total of 79 patients were included. Of these, 50.1% underwent transoral exoscope-assisted surgery, while 49.9% underwent primary transoral microscopic-assisted surgical approach. No significant differences were observed in terms of the University of Washington Quality of Life Questionnaire and Voice Handicap Index-10 between the two subgroups. Conversely, in the oro-hypopharyngeal cancer group, 43 patients were included. Of these, 37.2% underwent primary transoral exoscope-assisted surgery, while 62.8% received (chemo)radiotherapy. No notable differences were reported in terms of the University of Washington Quality of Life Questionnaire and M.D. Anderson Dysphagia Inventory between the transoral exoscope-assisted surgery and (chemo)radiotherapy subgroups.ConclusionsAssessments of quality of life, conducted through the University of Washington Quality of Life Questionnaire questionnaire, dysphonia evaluations using the Voice Handicap Index-10, and dysphagia assessments employing the M.D. Anderson Dysphagia Inventory questionnaire, demonstrate analogous outcomes between conventional treatment modalities and transoral interventions utilizing the 3D exoscope.
Kesepakatan Nuklir Iran 14 Juli 2015 Sebagai Model Perundingan Minilateral yang Efektif Meredam Dinamika Politik dan Keamanan Kawasan
Authors: Danieladi Wim Tohari 
Published: April 2024

Minilateralisme adalah sebuah konsep hubungan internasional yang melibatkan sekelompok kecil negara yang berkolaborasi untuk mengatasi masalah atau mencapai tujuan bersama. Pada prakteknya, minilateralisme memang memiliki kelemahan. Salah satu risikonya adalah bahwa hal ini dapat bersifat eksklusif dan memperburuk ketidakseimbangan kekuasaan sehingga berpotensi mengutamakan kepentingan jangka pendek dibandingkan tujuan jangka panjang. Meski demikian, manfaat minilateralisme lebih besar daripada kelemahannya. Dimana minilateralisme adalah pendekatan yang lebih cerdas dan tepat sasaran, yaitu menghadirkan sejumlah kecil negara yang diperlukan agar dapat memberikan dampak sebesar-besarnya dalam penyelesaian suatu masalah tertentu. Inilah angka ajaib (magic number) minilateralisme, yang tentu saja akan sangat bervariasi, tergantung masalahnya. Dalam kasus kesepakatan Nuklir Iran 14 Juli 2014, konsep minilateralisme ini menunjukan keajaibannya. Dimana ketergangan yang sudah berlangsung lebih dari empat decade antara Amerika Serikat dan sekutunya dengan Iran, berhasil mencapai common interest untuk menghasilkan kesepakatan yang optimal.
Kata kunci—Common Interest, Iran 14 Juli 2014, Kesepakatan Nuklir, Konstruktivisme, Minilateralisme, Multilateralisme
DECENTRALIZATION AS A FACTOR IN THE DEVELOPMENT OF TERRITORIAL COMMUNITIES IN UKRAINE: EXPERIENCE OF THE EU COUNTRIES
Authors: Yevchenko Veronika , Terenyak Liliya 
Published: April 2024

The analysis of modern Ukrainian political and legal research suggests that the theory is dominated by the understanding of the territorial organization of power according to which the territorial community is the basis for the organization of the system of community development management. According to the researchers, it is the excessive number of small administrative-territorial units of the basic level that has determined the need for reform. The lack of the necessary economic and human resources makes it impossible for basic local government units to effectively exercise their powers. The main problem of decentralization is that the creation of new territorial communities did not take into account resource provision, transportation tasks, and economic and geographical zoning in general. The author analyzes and compares the experience of EU countries in decentralization. To ensure a favorable climate for the decentralization process, special regional development institutions have been created in different countries as executive bodies that assist various departmental structures in their activities, and these can also be independent institutions for the development of regional development programs and fund management, public non-profit organizations, and other non-governmental organizations working in partnership with government institutions. Today, in the context of war, our state as a whole and each individual territorial community in particular lives by different principles, budgets are formed and used in a completely different way, many projects have been suspended, funds allocated for them have been redirected to other areas, and mass migration has taken place both within the country and abroad.
The article reveals that, according to the researchers, an excessive number of small administrative-territorial units of the basic level determined the need for decentralization reform. It is found that the main problem of decentralization is that the creation of new territorial communities did not take into account resource provision, transportation tasks, and economic and geographical zoning in general. The author analyzes and compares the experience of EU countries on decentralization issues. It is determined that the goals and objectives of the state policy on reform and decentralization are formed and coordinated with each other, they are specified in various programs and regulations. It can be argued that, in general, Ukraine is moving in the right direction in terms of reforming local self-government and territorial organization of power and covers all socially important areas.
EUROPEAN POLICY OF POLITICAL CORRECTNESS: GUIDELINES AND EXPERIENCE FOR UKRAINE
Authors: Yevtushenko Nataliya 
Published: April 2024

The article examines the phenomenon of political correctness in European Union countries, which is rooted in principles such as unity, tolerance, and cultural diversity. Originating in the United States as a response to discrimination, political correctness has permeated university environments as a tool to combat discriminatory behavior.
The ideology of political correctness encompasses views on the treatment of discriminatory groups and addresses issues such as feminism, sexism, racism, and homophobia. It has significantly influenced the ideological landscape of the United States and Western Europe, becoming a code of social linguistic behaviour aimed at preventing and mitigating social conflicts while improving political and legal culture.
It is shown that in Western European countries, representatives of social movements who proposed norms of linguistic behaviour and the use of euphemisms began to actively use the ideology of "political correctness" to obscure and veil phenomena that have a negative assessment in public consciousness and to prohibit manifestations of contemptuous, offensive, or discriminatory attitudes towards representatives of various minorities.
In Western European countries, proponents of social movements have adopted the ideology of political correctness to obscure negative phenomena in public consciousness and prohibit discriminatory behaviour towards minorities. This ideology not only reflects reality but also actively changes it, serving as an effective tool for preventing social conflicts and promoting respect for cultural diversity.
For Ukraine, aspiring to integrate into the European community, studying the European experience of political correctness offers insights into the political behaviour of modern European society. Political correctness serves as a communication tool aimed at fostering a conflict-free atmosphere and preventing social tensions.
YOUTH ENGAGEMENT IN CIVIL SOCIETY DEVELOPMENT IN UKRAINE: PROBLEMS AND SOLUTIONS
Authors: Palagnyuk Yuliana , Faichuk Olena , Kostieva Tetiana , Soloviova Anna , Say Dmytro 
Published: April 2024

The article outlines the ways of engaging young people in the development of civil society in Ukraine. Socially and politically active young people are one of the necessary conditions for forming a democratic society and establishing sustainable and functioning civil society institutions. Therefore, in this paper, the scholars aim to identify the ways of youth interaction with public authorities in Ukraine and general levels of youth civic engagement, as well as to characterize the culture of citizenship as a factor in involving young people in civil society development. The research reveals the relevant issue regarding the prominent role of civil society in various spheres of activity of state authorities and local self-government bodies, a qualitatively new level of interaction between civil society, especially youth as an active part of it, and state and local self-government bodies in order to establish effective dialogue and partnership relations of state bodies authorities, local self-government bodies with civil society organizations.
The research combined interdisciplinary approaches of several related scientific fields (political science, public administration and education), which allowed to set broader goals and find new ways for improving youth engagement in the development of civil society in Ukraine. The authors developed and conducted an expert survey on youth engagement in the development of civil society and identified possible ways to improve youth participation in public and political life. Authors interviewed 24 experts aged from 18 to 60 years from various fields who are interested in building a democratic state governed by the rule of law: leaders and members of public organizations, teachers of higher education institutions, scholars, deputies of regional and local councils, civil society activists and businessmen.
It was determined that the effective participation of youth in decision-making processes consists in creating opportunities to involve youth in influencing, shaping, developing and promoting policy and development of services and programs. These opportunities are created by developing a range of formal and informal mechanisms for youth participation, from youth advisory groups to focus groups, from ongoing consultation work to supporting youth projects. As a result of the study, the authors developed a set of conclusions and recommendations addressed to educational institutions, public authorities, local governments and civil society organizations.
APPLICATION OF PROGRESSIVE MANAGEMENT THEORIES FOR THE DEVELOPMENT OF THE MODERN UKRAINIAN MANAGEMENT MODEL
Authors: Verba Svitlana 
Published: April 2024

The importance of public management, especially in transitional systems or emergency situations, the problem of institutional adaptability to the realities of management has a priority basis. Of course, the development of a management approach in public administration should not be considered as a panacea, it also has quite fundamental limitations arising from the remaining rather serious differences between management in public and commercial organizations and the criteria for evaluating their performance. Thus, in public institutions, such a criterion, along with efficiency and effectiveness, is social justice, which has a valuable nature that goes beyond management.
In addition, there is one fundamental difference related to the huge impact of politics on public administration, without taking into account public management turns into only a rather narrow set of management technologies, the application of which can have rather limited consequences. Traditional management was built only on the principles of bureaucracy, while modern management is oriented towards adaptive systems that can create innovations in response to today's challenges.
4,4-Dimethylsterols Reduces Fat Accumulation via Inhibiting Fatty Acid Amide Hydrolase In Vitro and In Vivo
Authors: Zhang Tao , Xie Liangliang , Guo Yiwen , Wang Zhangtie , Guo Xin , Liu Ruijie , Jin Qingzhe , Chang Ming , Wang Xingguo 
Published: April 2024

4,4-Dimethylsterols constitute a unique class of phytosterols responsible for regulating endogenous cannabinoid system (ECS) functions. However, precise mechanism through which 4,4-dimethylsterols affect fat metabolism and the linkage to the ECS remain unresolved. In this study, we identified that 4,4-dimethylsterols, distinct from 4-demethseterols, act as inhibitors of fatty acid amide hydrolases (FAAHs) both in vivo and in vitro. Genetic ablation of FAAHs (
faah-1
) abolishes the effects of 4,4-dimethylsterols on fat accumulation and locomotion behavior in a
Caenorhabditis elegans
model. We confirmed that dietary intervention with 4,4-dimethylsterols in a high-fat diet (HFD) mouse model leads to a significant reduction in body weight (>11.28%) with improved lipid profiles in the liver and adipose tissues and increased fecal triacylglycerol excretion. Untargeted and targeted metabolomics further verified that 4,4-dimethylsterols influence unsaturated fatty acid biosynthesis and elevate oleoyl ethanolamine levels in the intestine. We propose a potential molecular mechanism in which 4,4-dimethylsterols engage in binding interactions with the catalytic pocket (Ser241) of FAAH-1 protein due to the shielded polarity, arising from the presence of 2 additional methyl groups (CH
3
). Consequently, 4,4-dimethylsterols represent an unexplored class of beneficial phytosterols that coordinate with FAAH-1 activity to reduce fat accumulation, which offers new insight into intervention strategies for treating diet-induced obesity.
Cathelicidin-HG Alleviates Sepsis-Induced Platelet Dysfunction by Inhibiting GPVI-Mediated Platelet Activation
Authors: Xiong Weichen , Chai Jinwei , Wu Jiena , Li Jiali , Lu Wancheng , Tian Maolin , Jmel Mohamed Amine , Ippel Johannes H. , Kotsyfakis Michail , Dijkgraaf Ingrid , Liu Shuwen , Xu Xueqing 
Published: April 2024

Platelet activation contributes to sepsis development, leading to microthrombosis and increased inflammation, which results in disseminated intravascular coagulation and multiple organ dysfunction. Although Cathelicidin can alleviate sepsis, its role in sepsis regulation remains largely unexplored. In this study, we identified Cath-HG, a novel Cathelicidin from
Hylarana guentheri
skin, and analyzed its structure using nuclear magnetic resonance spectroscopy. The modulatory effect of Cath-HG on the symptoms of mice with sepsis induced by cecal ligation and puncture was evaluated in vivo, and the platelet count, degree of organ damage, and microthrombosis were measured. The antiplatelet aggregation activity of Cath-HG was studied in vitro, and its target was verified. Finally, we further investigated whether Cath-HG could regulate thrombosis in vivo in a FeCl
3
injury-induced carotid artery model. The results showed that Cath-HG exhibited an α-helical structure in sodium dodecyl sulfate solution and effectively reduced organ inflammation and damage, improving survival in septic mice. It alleviated sepsis-induced thrombocytopenia and microthrombosis. In vitro, Cath-HG specifically inhibited collagen-induced platelet aggregation and modulated glycoprotein VI (GPVI) signaling pathways. Dot blotting, enzyme-linked immunosorbent assay, and pull-down experiments confirmed GPVI as the target of Cath-HG. Molecular docking and amino acid residue truncations/mutations identified crucial sites of Cath-HG. These findings suggest that GPVI represents a promising therapeutic target for sepsis, and Cath-HG may serve as a potential treatment for sepsis-related thrombocytopenia and thrombotic events. Additionally, identifying Cath-HG as a GPVI inhibitor provides insights for developing novel antithrombotic therapies targeting platelet activation mediated by GPVI.
PENGARUH KEMAMPUAN BERPIKIR KREATIF TERHADAP HASIL BELAJAR MATEMATIKA SISWA PADA MATERI LINGKARAN
Authors: Firdaus Firda , Yudhanegara Mokhammad Ridwan , Roesdiana Lessa 
Published: April 2024

Penelitian ini bertujuan untuk mengetahui adakah pengaruh kemampuan berpikir kreatif terhadap hasil belajar matematika siswa dan seberapa besarkah pengaruh kemampuan berpikir kreatif terhadap hasil belajar matematika siswa. Jenis penelitian yang digunakan adalah pendekatan kuantitatif. Populasi dalam penelitian ini adalah seluruh siswa SMP kelas VIII SMP Negeri 7 Karawang Barat. Pengambilan sampel dilakukan dengan teknik proporsionate stratified random sampling. Sampel penelitian berjumlah 132 siswa. Dalam penelitian ini pengumpulan data menggunakan instrumen tes kemampuan berpikir kreatif dan hasil Ulangan Tengah Semester (UTS) siswa. Data diolah dan dianalisis menggunakan uji regresi linear sederhana dengan menggunakan software IBM SPSS Statistics 25. Hipotesis dalam penelitian ini adalah terdapat pengaruh yang signifikan antara kemampuan berpikir kreatif terhadap hasil belajar matematika siswa pada materi lingkaran kelas VIII SMP Negeri 7 Karawang Barat. Hasil penelitian ini menunjukkan bahwa kemampuan berpikir kreatif berpengaruh secara signifikan terhadap hasil belajar matematika siswa pada materi lingkaran dengan tingkat siginifikansi dan nilai t hitung sebesar . Adapun besar pengaruh antara keduanya yaitu sebesar 62,6 % yang ditunjukan oleh nilai koefisien deteminasi (R Square ) sebesar 0,626.
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS ANDROID PADA PEMBELAJARAN TEKS DEBAT SISWA KELAS X
Authors: Putri Adinda Insani 
Published: April 2024

Pesatnya perkembangan IPTEK pada dunia pendidikan di abad 21, mengharuskan seorang guru dapat menyesuaikan bahan ajar dan madia pembelajaran yang digunakan. Salah satu media pembelajaran yang sesuai dengan karakteristik pembelajaran di abad 21 yaitu penggunaan media pembelajaran berbasis android. Dengan mempertimbangkan permasalahan yang ada,penelitian ini bertujuan untuk memberikan salah satu amedia pembelajaran yang dapat membantu seorang pendidik dan juiga peserta didik dalam pembelajaran Bahasa Indonesia khusunya dalam pembelajaran teks debat. Metode penelitian yang digunakan pada penelitian ini yaitu metode penelitian Research and Development dengan mengacu pada model Sommerville. Teknik pengumpulan data pada penelitian ini menggunakan teknik deskriptif kualitatif. Hasil dari pengembangan media pembelajaran berbasis android yaitu terciptanya salah satu aplikasi Kelas Debat yang mengacu pada permasalahan yang ada pada Siswa SMKelas X
PENGARUH KESIAPAN BELAJAR DAN DUKUNGAN ORANG TUA TERHADAP KEPERCAYAAN DIRI ANAK
Authors: Kuswantini Yogi , Priyanti Nita 
Published: April 2024

Permasalahan kepercayaan diri menjadi tantangan tersendiri bagi anak usia dini atau prasekolah. Bersiap-siap memasuki usia sekolah, anak usia dini membutuhkan kemampuan beradaptasi yang baik terhadap berbagai perubahan yang terjadi. Kemampuan beradaptasi terhadap perubahan lingkungan, interaksi sosial, dan tuntutan akademis membutuhkan kepercayaan diri anak. Peran orang tua dianggap penting untuk memberikan dukungan bagi terbangunnya kepercayaan diri anak. Demikian pula dengan kesiapan belajar anak yang dianggap penting untuk membangun kepercayaan diri mereka dalam beradaptasi. Penelitian dengan pendekatan kuantitatif ini bertujuan mengungkapkan pengaruh kesiapan belajar dan dukungan orang tua terhadap kepercayaan diri anak usia dini. Data penelitian diperoleh melalui kuesioner dan diolah dengan menggunakan perangkat lunak SPSS V26.0 for Windows. Sebelum pengujian hipotesis, dilakukan uji validitas, reliabilitas, dan normalitas data. Pembuktian hipotesis menunjukkan adanya pengaruh kesiapan belajar dan dukungan orang tua terhadap kepercayaan diri anak usia dini. Dari regresi linier berganda diperoleh hasil bahwa variabel bebas, baik kesiapan belajar maupun dukungan orang tua secara parsial berpengaruh positif dan signifikan terhadap variabel terikat kepercayaan diri (uji t). Kesiapan belajar dan dukungan orang tua secara simultan berpengaruh positif dan signifikan terhadap kepercayaan diri (uji F). Kesiapan belajar dan dukungan orang tua memiliki kontribusi sebesar 55,2% terhadap kepercayaan diri (uji koefisien determinasi)
Methodological characteristics of statistical support of regional innovation policy
Authors: Dvas G. V. , Busheneva Yu. I. 
Published: April 2024

Aim. To identify the possibilities of expanding the general sample of organizations involved in the provision of statistical data regarding the issues of innovation activity implementation to improve the quality of information in decision-making within the framework of regional innovation policy implementation.Objectives. To determine the significance of statistical information for the processes of strategic planning in the country and regions; to identify the problems of adequate reflection of innovation activity in modern Russian statistics; to establish the deviations of the methodological apparatus of Rosstat from the recommendations of the Oslo Manual; to analyze some statistical parameters of innovation activity in the regions of the North-West of Russia; to develop recommendations for changing the approaches of Rosstat to the organization of statistical observation in the sphere of innovation activity.Methods. The article characterizes the state of innovation statistics in the country on the basis of analysis methods. The method of pair correlation allowed to reveal the inconsistency of the parameters of innovation activity of organizations with the key economic indicators of regional development.Results. The authors have identified two main directions of expanding the general sample of organizations when conducting innovation statistics: a larger-scale inclusion of service sector enterprises in the list of surveyed organizations and a decrease in the number of personnel of organizations, starting from which organizations are obliged to provide statistical information on the issues of innovation activity, from 15 to 10 people. In addition, the article substantiates the necessity of applying in Russia the subject approach to the statistical survey of innovation activity of enterprises, which contributes to the identification of factors that affect the innovation activity of organizations, and the assessment of such an impact, taking into account regional characteristics.Conclusions. The change of approaches to innovation statistics will provide the authorities in the regions with correct information for more effective realization of regional innovation policy.