bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Early Ordovician bathyurid trilobites Licnocephala and Ibexocephala
Authors: Adrain Jonathan M. 
Published: February 2025

AbstractRevision of the type species of the Early Ordovician (Tulean, late Tremadocian) bathyurid trilobite Licnocephala Ross, 1951 demonstrates that it has significantly different morphology than that ascribed to it in the earlier literature, which was based largely on species now assigned to a different genus. In addition to the type species, L. bicornuta Ross, 1951, which is fully revised on the basis of new material, four species, all apparently new, have been recovered, two of which, L. ngi n. sp. and L. bradleyi n. sp., are well enough known to formally name. The overall phylogenetic structure of bathyurids is yet to be determined, but several apparent clades can now be recognized and are discussed. Among these is what is termed the “Chapmanopyge group,” including Chapmanopyge Fortey and Bruton, 2013, Punka Fortey, 1979, Uromystrum Whittington, 1953, and Licnocephala. These genera are united in the occurrence of much of the anterior cephalic border on the librigenal anterior projection, with most of the anterior margin of the cranidium representing the suture, the possession of very short (exsag.) strap-like posterior cranidial projections, and extremely narrow visual surfaces. A fifth genus of the group, Ibexocephala n. gen., is represented by two new species, I. lossoae (type species) and I. dekosterae. The taxon features a remarkable cranidial morphology involving a strong deflection of the posteriormost part of the cranidium from the anterior part in sagittal profile.UUID: http://zoobank.org/ab9a8796-84c7-48b1-b0e5-84a22511a6b4
Was Sor Juana a Sphinx? Monstrosity and the Poetics of Dedication in Her Transoceanic Enigmas
Authors: Sierra Matute Víctor 
Published: February 2025

Abstract
This article explores Sor Juana Inés de la Cruz’s (1648–1695) strategic poetic approach, aimed at democratizing writing and knowledge among women during her period. It examines her engagement with the literary academy, Casa del Placer, believed to have included nuns from Portuguese convents and women of the nobility. Specifically, the study analyzes Sor Juana’s final poetic work, the Enigmas ofrecidos a la Casa del Placer (1695), comprising twenty unanswerable poetic enigmas. In this collection, Sor Juana departs from individual lyric expression, a shift I call a “poetics of dedication,” advocating for a communal cultural identity centered on her persona’s fame. Through this gesture, Sor Juana appropriates and challenges patriarchal narratives that labeled her as a “monster” due to her perceived exceptionalism. My article shows how, toward the end of her life, Sor Juana embraces and subverts discussions about her exceptional status and transatlantic identity, fostering a sense of transoceanic sorority among women writers of the colonial period.
The Revolution Must Be Published: Toward a Radically Inclusive Publishing Ecology
Authors: Fisher-Livne Daniel , Burton Kath , Cocks Catherine 
Published: February 2025

Abstract
The humanities cannot go public without publishing. In this contribution to the Manifesto issue of Public Humanities, Daniel Fisher-Livne, Kath Burton, and Catherine Cocks highlight the radically inclusive publishing practices necessary to support the Public Humanities ecosystem. The authors explain how Publishing and the Publicly Engaged Humanities Working Group activities have prepared the ground for future growth, directing attention to the inherently collaborative, multimodal and values-based publishing practices of engaged scholars. This paper builds on the central thesis of the Working Group, calling for the implementation of a radically inclusive ecology of publishing practices that embody and nurture the unique facets, connections and aims of publicly engaged publications.
Can Schistosoma japonicum infection cause liver cancer?
Authors: Jain S. 
Published: February 2025

Abstract
A co-relation between Schistosoma japonicum (Sj) and liver cancer (LC) in humans has been reported in the literature; however, this association is circumstantial. Due to the inconclusive nature of this association, the International Agency for Research on Cancer has placed Sj in Group 2B for LC, signifying it to be a ‘possible carcinogen’. Many epidemiological, pathological and clinical studies have identified multiple factors, linked with Sj infection, which can lead to liver carcinogenesis. These factors include chronic inflammation in response to deposited eggs (which leads to fibrosis, cirrhosis and chromosomal instability at cellular level), hepatotoxic effects of egg-antigens, co-infection with hepatitis viruses, and up-regulation of glycolysis linked genes among others which predisposes hepatic tissue towards malignant transformation. The objective of this work is to present the current understanding on the association of Sj infection with LC. Mechanisms and factors linked with Sj infection that can lead to LC are emphasized, along with measures to diagnose and treat it. A comparison of liver carcinogenesis is also provided for cases linked with and independent of Sj infection. It appears that Sj, alone or with another carcinogen, is an important factor in liver carcinogenesis, but further studies are warranted to conclusively label ‘infection with Sj alone’ as a liver carcinogen.
Synthetic camphor derivative (E)-2-((1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene)amino)phenol: A novel anthelmintic drug candidate for visceral toxocariasis
Authors: Rodrigues D.C. , de Oliveira da Cunha C.N. , Faria A.M. , Panassolo V.P. , Martins L.H.R. , de Souza M.V.N. , de Souza M.C.F.D. , Munhoz L.S. , da Costa de Avila L.F. , Ramos D.F. , Scaini C.J. 
Published: February 2025

Abstract
Human toxocariasis is a neglected parasitic disease with a global distribution, treated with current anthelmintics that have low to moderate efficacy, and requires the discovery of novel drugs. Camphor derivatives have antimicrobial properties against various pathogens such as fungi and bacteria. This study aimed to identify a camphor derivative with activity against Toxocara canis larvae and evaluate its cytotoxicity, in silico bioavailability, and in vivo activity in Swiss mice infected with this parasite. Three compounds were tested in vitro in duplicate at a concentration of 1.0 to 0.05 mg/mL in a microplate containing 100 T. canis larvae in RPMI-1640 medium incubated for 48 h at 37°C and 5% CO2. The compound (E)-2-((1,7,7-trimethylbicyclo [2.2.1] heptan-2-ylidene)amino)phenol (C2) presented a minimum larvicidal concentration (MLC) of 0.25 mg/mL and was selected for the subsequent steps. This compound showed 100% cell viability in MLC and adequate bioavailability in computational models. Two subsequent in vivo tests were performed on Swiss mice inoculated with 500 T. canis infective eggs through intragastric (IG) intubation, one at 10 days post-inoculation (n=5) and the other at 30 days post-inoculation (n=10). The selected compound (10 mg/kg, via IG) and two controls (albendazole, 40 mg/kg, IG and phosphate buffered saline 0,15M, pH 7,2, via IG) were used for this evaluation. The compound reduced the intensity of infection by 75.7% and 54.8% at 10 and 30 days post inoculation, respectively (p<0.05). The results of this study demonstrate that this compound has potential as an anthelmintic candidate for visceral toxocariasis treatment.
New origins to vowel tensing in Tangut: internal and comparative evidence
Authors: Zhang Shuya , Lai Yunfan 
Published: February 2025

Abstract
This paper proposes new origins for tense vowels in Tangut by integrating textual analysis of Tangut texts with comparative data from both Gyalrongic and other Sino-Tibetan languages. It uncovers two previously unreported sources of vowel tensing in compounding: the collective prefix (*S-) and the compound linker (*-S-). Both morphemes left only a few traces, indicating their antiquity and productivity in earlier stages. The collective *S- could be an inherited morpheme which finds parallels in Tibetan, whereas the compound linker *-S- emerged as a stage of morphological merging in West Gyalrongic with (an) obscure origin(s). These findings not only advance our understanding of the origins of Tangut tense vowels but also offer insights into Sino-Tibetan nominal morphology.
A large compact, 2-D expandable RFID reader antenna for near-field applications
Authors: Niu Yaohui , Li Xiuping , Zhao Wenyu , Qi Zihang 
Published: February 2025

Abstract
In this paper, a large, compact array antenna that can be expanded in the 2-D plane is proposed for near-field radio frequency identification applications. By the introduction of the fractal structure and corner joint method, the array is easy to expand in the 2-D plane. An antenna element can be divided into a dozen or so loops, and traveling wave distribution makes sure that every loop is excited in a time period. So that a strong and uniform magnetic field could be generated in a large area. As a proof of concept, array antennas with

$1 \times 8$

,

$2 \times 4$

, and

$3 \times 3$

elements are designed, fabricated, and measured. The measured bandwidth of the antennas covers the entire Chinese standard. Reading distances of the proposed large array antennas achieved up to 57 mm. Results show that the proposed antenna could realize flexibility and extendibility in a large area with stable and uniform magnetic field distribution.
Frontier molecular orbital weighted model based networks for revealing organic delayed fluorescence efficiency
Authors: He Zhaoming , Bi Hai , Liang Baoyan , Li Zhiqiang , Zhang Heming , Wang Yue 
Published: February 2025

Abstract
Free of noble-metal and high in unit internal quantum efficiency of electroluminescence, organic molecules with thermally activated delayed fluorescence (TADF) features pose the potential to substitute metal-based phosphorescence materials and serve as the new-generation emitters for the mass production of organic light emitting diodes (OLEDs) display. Predicting the function of TADF emitters beyond classic chemical synthesis and material characterization experiments remains a great challenge. The advances in deep learning (DL) based artificial intelligence (AI) offer an exciting opportunity for screening high-performance TADF materials through efficiency evaluation. However, data-driven material screening approaches with the capacity to access the excited state properties of TADF emitters remain extremely difficult and largely unaddressed. Inspired by the fundamental principle that the excited state properties of TADF molecules are strongly dependent on their D-A geometric and electronic structures, we developed the Electronic Structure-Infused Network (ESIN) for TADF emitter screening. Designed with capacities of accurate prediction of the photoluminescence quantum yields (PLQYs) of TADF molecules based on elemental molecular geometry and orbital information and integrated with frontier molecular orbitals (FMOs) weight-based representation and modeling features, ESIN is a promising interpretable tool for emission efficiency evaluation and molecular design of TADF emitters.
Imaging flow cytometry with a real-time throughput beyond 1,000,000 events per second
Authors: Zhou Jiehua , Mei Liye , Yu Mingjie , Ma Xiao , Hou Dan , Yin Zhuo , Liu Xun , Ding Yan , Yang Kaining , Xiao Ruidong , Yuan Xiandan , Weng Yueyun , Long Mengping , Hu Taobo , Hou Jinxuan , Xu Yu , Tao Liang , Mei Sisi , Shen Hui , Yalikun Yaxiaer , Zhou Fuling , Wang Liang , Wang Du , Liu Sheng , Lei Cheng 
Published: February 2025

Abstract
Imaging flow cytometry (IFC) combines the imaging capabilities of microscopy with the high throughput of flow cytometry, offering a promising solution for high-precision and high-throughput cell analysis in fields such as biomedicine, green energy, and environmental monitoring. However, due to limitations in imaging framerate and real-time data processing, the real-time throughput of existing IFC systems has been restricted to approximately 1000-10,000 events per second (eps), which is insufficient for large-scale cell analysis. In this work, we demonstrate IFC with real-time throughput exceeding 1,000,000 eps by integrating optical time-stretch (OTS) imaging, microfluidic-based cell manipulation, and online image processing. Cells flowing at speeds up to 15 m/s are clearly imaged with a spatial resolution of 780 nm, and images of each individual cell are captured, stored, and analyzed. The capabilities and performance of our system are validated through the identification of malignancies in clinical colorectal samples. This work sets a new record for throughput in imaging flow cytometry, and we believe it has the potential to revolutionize cell analysis by enabling highly efficient, accurate, and intelligent measurement.
Polarization-controlled chiral transport
Authors: Zhu Hang , Wang Jian , Alù Andrea , Chen Lin 
Published: February 2025

Abstract
Handedness-selective chiral transport is an intriguing phenomenon that not only holds significant importance for fundamental research but also carries application prospects in fields such as optical communications and sensing. Currently, on-chip chiral transport devices are static, unable to modulate the output modes based on the input modes. This limits both device functionality reconfiguration and information transmission capacity. Here, we propose to use the incident polarization diversity to control the Hamiltonian evolution path, achieving polarization-dependent chiral transport. By mapping the evolution path of TE and TM polarizations onto elaborately engineered double-coupled waveguides, we experimentally demonstrate that different polarizations yield controllable modal outputs. This work combines Multiple-Input, Multiple-Output, and polarization diversity concepts with chiral transport and challenges the prevailing notion that the modal outputs are fixed to specific modes in chiral transport, thereby opening pathways for the development of on-chip reconfigurable and high-capacity handedness-selective devices.
Rare earth stibolyl and bismolyl sandwich complexes
Authors: Schwarz Noah , Bruder Florian , Bayer Valentin , Moreno-Pineda Eufemio , Gillhuber Sebastian , Sun Xiaofei , van Slageren Joris , Weigend Florian , Roesky Peter W. 
Published: February 2025

Abstract
The design of molecular rare earth complexes to achieve unique magnetic and bonding properties is a growing area of research with possible applications in advanced materials and molecular magnetics. Recent efforts focus on developing ligand frameworks that can enhance magnetic characteristics. Here we show the synthesis and characterization of a class of rare earth complexes, [(η5-C4R4Sb)Ln(η8-C8H8)] and [(η5-C4R4Bi)Ln(η8-C8H8)], featuring η5-coordinated stibolyl and bismolyl ligands. The ligand aromaticity and bonding situation within these complexes are investigated by quantum chemical calculations. Magnetic studies of the ErIII analogues reveal large barriers and intriguing properties, including waist-restricted hysteresis and slow relaxation of the magnetization, making them single-molecule magnets. Comparison between the experimental barrier and CASSCF-SO calculations indicates that relaxation in all systems occurs through high-energy excited states. These findings suggest that stibolyl and bismolyl ligands can be promising candidates for achieving high-energy barriers in Er-based SMMs, offering a pathway to molecular designs with enhanced magnetic properties.
Spin density wave in the bilayered nickelate La3Ni2O7−δ at ambient pressure
Authors: Ni Xiao-Sheng , Ji Yuyang , He Lixin , Xie Tao , Yao Dao-Xin , Wang Meng , Cao Kun 
Published: February 2025

Abstract
The recent discovery of high-temperature superconductivity in high-pressurized La3Ni2O7−δ
has garnered significant attention. Using density functional theory, we investigate the magnetic properties of La3Ni2O7−δ
at ambient pressure. Our calculations suggest that with δ = 0, the double spin stripe phase is favored as the magnetic ground state. Oxygen vacancies may effectively turn nearest Ni spins into charge sites. Consequently, with moderate δ values, our theoretical magnetic ground state exhibits characteristics of both double spin stripe and spin-charge stripe configurations, providing a natural explanation to reconcile the seemingly contradictory experimental findings that suggest both the configurations as candidates for the spin-density-wave phase. With higher δ values, we anticipate the ground state to become a spin-glass-like noncollinear magnetic phase with only short-range order. The oxygen vacancies are expected to significantly impact the magnetic excitations and the transition temperatures T

S
D
W
. Notably, the magnetic ordering also induces concomitant charge ordering and orbital ordering, driven by spin-lattice coupling under the low symmetry magnetic order. We further offer a plausible explanation for the experimental observations that the measured T

S
D
W
appears insensitive to the variation of samples and the lack of direct evidence for long-range magnetic ordering.
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants
Authors: Feng Shouya , Wierzbowski Matthew C. , Hrovat-Schaale Katja , Dumortier Andreas , Zhang Yaoyuan , Zyulina Maria , Baker Paul J. , Reygaerts Thomas , Steiner Annemarie , De Nardo Dominic , Narayanan Dhanya Lakshmi , Milhavet Florian , Pinzon-Charry Alberto , Arostegui Juan Ignacio , Khubchandani Raju P. , Geyer Matthias , Boursier Guilaine , Masters Seth L. 
Published: February 2025

Abstract
The NLRP3 inflammasome is a multiprotein complex that mediates caspase-1 activation and the release of proinflammatory cytokines, including interleukin (IL)-1β and IL-18. Gain-of-function variants in the gene encoding NLRP3 (also called cryopyrin) lead to constitutive inflammasome activation and excessive IL-1β production in cryopyrin-associated periodic syndromes (CAPS). Here we present functional screening and automated analysis of 534 NLRP3 variants from the international INFEVERS registry and the ClinVar database. This resource captures the effect of NLRP3 variants on ASC speck formation spontaneously, at low temperature, after inflammasome stimulation and with the specific NLRP3 inhibitor MCC950. Most notably, our analysis facilitated the updated classification of NLRP3 variants in INFEVERS. Structural analysis suggested multiple mechanisms by which CAPS variants activate NLRP3, including enhanced ATP binding, stabilizing the active NLRP3 conformation, destabilizing the inactive NLRP3 complex and promoting oligomerization of the pyrin domain. Furthermore, we identified pathogenic variants that can hypersensitize the activation of NLRP3 in response to nigericin and cold temperature exposure. We also found that most CAPS-related NLRP3 variants can be inhibited by MCC950; however, NLRP3 variants with changes to proline affecting helices near the inhibitor binding site are resistant to MCC950, as are variants in the pyrin domain, which likely trigger activation directly with the pyrin domain of ASC. Our findings could help stratify the CAPS population for NLRP3 inhibitor clinical trials and our automated methodologies can be implemented for molecules with a different mechanism of activation and in laboratories worldwide that are interested in adding new functionally validated NLRP3 variants to the resource. Overall, our study provides improved diagnosis for patients with CAPS, mechanistic insight into the activation of NLRP3 and stratification of patients for the future application of targeted therapeutics.
Recent increase in surface melting of West Antarctic ice shelves linked to Interdecadal Pacific Oscillation
Authors: Deb Pranab , Bromwich David , Orr Andrew , Sen Arnab , Clem Kyle R. 
Published: February 2025

Abstract
Since the late 1990s, summer surface melt across ice shelves in the Ross-Amundsen Sea sector of West Antarctica increased significantly, as demonstrated by satellite measurements and MetUM simulations. This contrasts with the period from 1979 to the late 1990s, which witnessed a decreasing summer melt trend driven by the positive trend in Southern Annular Mode. The increase in summer melt since the late 1990s is linked to an increase in geopotential height and intensified anticyclonic blocking along coastal West Antarctica, which strengthened northerly winds over the Ross-Amundsen Sea sector, leading to enhanced advection of warm, marine air. Our analysis reveals a strong connection between summer melt indices and sea surface temperatures in the South Pacific Convergence Zone during this period. Moreover, increased summer precipitation in South Pacific Convergence Zone since the late 1990s strengthened the Rossby wave teleconnection toward West Antarctica, contributing to enhanced blocking along the coastal region. This is consistent with the transition of the Interdecadal Pacific Oscillation to its negative phase.
Proteogenomic analysis reveals adaptive strategies for alleviating the consequences of aneuploidy in cancer
Authors: Bökenkamp Jan-Eric , Keuper Kristina , Redel Stefan , Barthel Karen , Johnson Leah , Becker Amelie , Wieland Angela , Räschle Markus , Storchová Zuzana 
Published: February 2025

Abstract
Aneuploidy is prevalent in cancer and associates with fitness advantage and poor patient prognosis. Yet, experimentally induced aneuploidy initially leads to adverse effects and impaired proliferation, suggesting that cancer cells must adapt to aneuploidy. We performed in vitro evolution of cells with extra chromosomes and obtained cell lines with improved proliferation and gene expression changes congruent with changes in aneuploid cancers. Integrated analysis of cancer multi-omics data and model cells revealed increased expression of DNA replicative and repair factors, reduced genomic instability, and reduced lysosomal degradation. We identified E2F4 and FOXM1 as transcription factors strongly associated with adaptation to aneuploidy in vitro and in cancers and validated this finding. The adaptation to aneuploidy also coincided with specific copy number aberrations that correlate with poor patient prognosis. Chromosomal engineering mimicking these aberrations improved aneuploid cell proliferation, while loss of previously present extra chromosomes impaired it. The identified common adaptation strategies suggest replication stress, genomic instability, and lysosomal stress as common liabilities of aneuploid cancers.
A CRISPR-Cas9 screen reveals genetic determinants of the cellular response to decitabine
Authors: Zhang Pinqi , Zhang Zhuqiang , Wang Yiyi , Du Wenlong , Song Xingrui , Lai Weiyi , Wang Hailin , Zhu Bing , Xiong Jun 
Published: February 2025

Abstract
Decitabine (DAC), a well-recognized DNA hypomethylating agent, has been applied to treat acute myeloid leukemia. However, clinic investigations revealed that DNA methylation reduction does not correlate with a clinical response, and relapse is prevalent. To gain a better understanding of its anti-tumor mechanism, we perform a temporally resolved CRISPR-Cas9 screen to identify factors governing the DAC response. We show that DNA damage generated by DNMT-DNA adducts and 5-aza-dUTP misincorporation through the dCMP deaminase DCTD act as drivers of DAC-induced acute cytotoxicity. The DNA damage that arises during the next S phase is dependent on DNA replication, unveiling a trans-cell cycle effect of DAC on genome stability. By exploring candidates for synthetic lethality, we unexpectedly uncover that KDM1A promotes survival after DAC treatment through interactions with ZMYM3 and CoREST, independent of its demethylase activity or regulation of viral mimicry. These findings emphasize the importance of DNA repair pathways in DAC response and provide potential biomarkers.