bluuebunny/crossref_metadata_2025_split huggingface dataset:
Egoviruses: distant relatives of poxviruses abundant in the gut microbiomes of humans and animals worldwide
Authors: Gaïa Morgan , Ruscheweyh Hans-Joachim , Eren A. Murat , Koonin Eugene V. , Sunagawa Shinichi , Krupovic Mart , Delmont Tom O. 
Published: March 2024

AbstractLarge and giant double-stranded DNA viruses within the phylumNucleocytoviricotaare diverse and prevalent in the environment where they substantially affect the ecology and evolution of eukaryotes1–4. Until now, these viruses were only sporadically found in the digestive system of vertebrates5–7. Here, we present the identification and genomic characterization of a proposed third order of viruses within the classPokkesviricetesthat currently consists of poxvirusesand asfuviruses8. Members of this newly identified order we provisionally named “Egovirales” are commonly in the digestive system of vertebrates worldwide and are abundant in >10% of livestock animals, >2% of humans, and wild animals. Egoviruses have linear genomes up to 467 kbp in length and likely form multilayered icosahedral capsids, similar to those of asfuviruses. However, phylogenetic analysis of conserved viral genes indicates that egoviruses are the sister group of poxviruses, with implications for capsid evolution. The diversity of egoviruses already far exceeds that of all known poxviruses and animal-associated asfuviruses. Phylogenetic analyses and patterns of virus distribution across vertebrates suggest that egoviruses can be either specialists or generalists associated with a single or multiple vertebrate species, respectively. Notably, one egovirus clade is human-specific, evolutionarily constrained, and spread across continents, demonstrating a long-term association betweenEgoviralesand the human population on the global scale. Egoviruses not only expand the ecological and evolutionary scope ofPokkesviricetes, but also represent the only diverse, widespread, and abundant group of double-stranded DNA viruses infecting eukaryotic cells in the digestive system of vertebrates.
The joint effect of value diversity and emotional intelligence on team creativity: evidence from Vietnam
Authors: Nguyen Nhu Ngoc , Nham Phong Tuan , Takahashi Yoshi 
Published: March 2024

PurposeThis study aims to examine the relationship between a team’s value diversity (VD) and creativity and investigate the moderating effect of emotional intelligence (EI) to explain inconsistent results regarding this relationship.Design/methodology/approachWe conducted a cross-sectional sequential study with 340 employees and tested the hypothesis in a laboratory setting with 180 undergraduate students.FindingsEI had a moderating effect on the relationship between a team’s VD and creativity in that the relationship was positive among teams with high EI. However, the relationship tended to be negative in the long term among teams with low EI.Practical implicationsManagers should pay attention to how teams benefit from VD because it can help or harm team performance. By assigning people with different EI levels into suitable teams and providing EI interventions, organizations may manage affective consequences and enjoy more benefits of cognitive consequences resulting from VD.Originality/valueNo previous study has investigated the effect of a team’s EI in the relationship between VD and team creativity. Drawing on the categorization-elaboration model of diversity and affective events theory, through the present two-study design, we obtained data from multiple sources and improved limitations in measurements of previous studies, thereby broadening the literature by highlighting the dynamic relationship between a team’s EI, VD and creativity in the Vietnamese context.
Integrated quality 4.0 framework for quality improvement based on Six Sigma and machine learning techniques towards zero-defect manufacturing
Authors: Gonzalez Santacruz Elisa , Romero David , Noguez Julieta , Wuest Thorsten 
Published: March 2024

PurposeThis research paper aims to analyze the scientific and grey literature on Quality 4.0 and zero-defect manufacturing (ZDM) frameworks to develop an integrated quality 4.0 framework (IQ4.0F) for quality improvement (QI) based on Six Sigma and machine learning (ML) techniques towards ZDM. The IQ4.0F aims to contribute to the advancement of defect prediction approaches in diverse manufacturing processes. Furthermore, the work enables a comprehensive analysis of process variables influencing product quality with emphasis on the use of supervised and unsupervised ML techniques in Six Sigma’s DMAIC (Define, Measure, Analyze, Improve and Control) cycle stage of “Analyze.”Design/methodology/approachThe research methodology employed a systematic literature review (SLR) based on PRISMA guidelines to develop the integrated framework, followed by a real industrial case study set in the automotive industry to fulfill the objectives of verifying and validating the proposed IQ4.0F with primary data.FindingsThis research work demonstrates the value of a “stepwise framework” to facilitate a shift from conventional quality management systems (QMSs) to QMSs 4.0. It uses the IDEF0 modeling methodology and Six Sigma’s DMAIC cycle to structure the steps to be followed to adopt the Quality 4.0 paradigm for QI. It also proves the worth of integrating Six Sigma and ML techniques into the “Analyze” stage of the DMAIC cycle for improving defect prediction in manufacturing processes and supporting problem-solving activities for quality managers.Originality/valueThis research paper introduces a first-of-its-kind Quality 4.0 framework – the IQ4.0F. Each step of the IQ4.0F was verified and validated in an original industrial case study set in the automotive industry. It is the first Quality 4.0 framework, according to the SLR conducted, to utilize the principal component analysis technique as a substitute for “Screening Design” in the Design of Experiments phase and K-means clustering technique for multivariable analysis, identifying process parameters that significantly impact product quality. The proposed IQ4.0F not only empowers decision-makers with the knowledge to launch a Quality 4.0 initiative but also provides quality managers with a systematic problem-solving methodology for quality improvement.
An efficient elastic full‐waveform inversion of multiple parameters with ocean‐bottom seismometer data
Authors: Huang Xinquan , Liu Yuzhu 
Published: March 2024

AbstractDetailed knowledge of the subsurface elastic properties might provide much‐needed insight into the subduction‐zone structure and the estimation of reservoir parameters. Compressional and shear wave velocities can be inverted by elastic full‐waveform inversion using multicomponent ocean‐bottom seismometer data. However, this process is computationally intensive, requiring massive, repeated simulations scaling with the number of sources. Although source–receiver reciprocity can streamline elastic full‐waveform inversion, it cannot be applied by directly interchanging the positions of sources and ocean‐bottom seismometers. To reduce the computational cost, we develop a source–receiver reciprocal elastic full‐waveform inversion, in which the reciprocity in multicomponent data can be accomplished by transforming the data matching from the original geometry to a specific form under the reciprocal geometry. This approach significantly reduces computational costs from twice the number of sources, as seen in conventional elastic full‐waveform inversion, to a scale with the count of ocean‐bottom seismometers. The tests on synthetic data verify that the proposed reciprocal elastic full‐waveform inversion maintains accuracy while improving computational efficiency, and further application on the field data from East China Sea also showcases the efficiency of the proposed method, resulting in a speed‐up of 10 times.
How Do Prestigious Universities Remain at the Summit: A Bourdieusian View of their Business Models
Authors: Bocquet Rachel , Cotterlaz‐Rannard Gaëlle , Ferrary Michel 
Published: March 2024

AbstractThis study investigates how the specificity of a university business model supports the dominance and persistence of a handful of elite non‐profit universities, while considering the implications this phenomenon has on social responsibility. Despite their longstanding positions at the top of academia for over four decades, these universities often struggle to actively embrace social mobility, diversity and inclusion. The existing literature on business models lacks a comprehensive conceptualization that captures the ability of some institutions to establish and maintain their domination within non‐economic fields, such as higher education. Drawing on Bourdieu's framework and a unique dataset comprising 192 private non‐profit American universities, the study uncovers two fundamental mechanisms of accumulation and conversion of forms of capital (economic, social, cultural and symbolic) behind the perpetuation of dominance among non‐profit universities. This research contributes to both business model and higher education studies by introducing a novel conceptual tool for investigating the business models of non‐profit universities. Important managerial and social implications, including a call for leading non‐profit universities to enact socially responsible and diversifying measures, follows.
Safety and efficacy of a reduced frequency viral monitoring strategy for Epstein‐Barr virus, cytomegalovirus, and BK polyomavirus post‐kidney transplant: A quality assurance initiative
Authors: Rampersad Christie , Kong William , Wiebe Chris , Balshaw Robert , Bullard Jared , Villalobos Armelle Perez Cortes , Trachtenberg Aaron , Shaw James , Karpinski Martin , Nickerson Peter W. , Ho Julie 
Published: March 2024

AbstractBackgroundThere is variability in recommended viral monitoring protocols after kidney transplant. In response to increased demand for laboratory testing during the COVID‐19 pandemic, the Transplant Manitoba Adult Kidney Program updated its monitoring protocols for cytomegalovirus (CMV), Epstein‐Barr virus (EBV), and BK polyomavirus (BKV) to a reduced frequency.MethodsThis single‐center nested case‐control study evaluated 252 adult kidney transplant recipients transplanted from 2015 to 2021, with the updated protocols effective on March 19th 2020. Cases included recipients transplanted after the protocol update who developed CMV, EBV, and BKV DNAemia and were matched to controls with DNAemia transplanted prior to the protocol update. The primary outcome was the difference in maximum DNA load titers between cases and matched controls. Secondary outcomes included time to initial DNAemia detection and DNAemia clearance. Safety outcomes of tissue‐invasive viral disease were described.ResultsThere were 216 recipients transplanted preupdate and 36 recipients postupdate. There was no difference between cases and controls in maximum or first DNA load titers for EBV, CMV, or BKV. Cases experienced earlier EBV DNAemia detection (26 (IQR 8, 32) vs. 434 (IQR 96, 1184) days, p = .005). Median follow‐up was significantly longer for recipients transplanted preupdate (4.3 vs. 1.3 years, p < .0001). After adjusting for follow‐up time, there was no difference in DNAemia clearance or tissue‐invasive viral disease.ConclusionOur findings suggest that reduced frequency viral monitoring protocols may be safe and cost‐effective. This quality assurance initiative should be extended to detect longer‐term and tissue‐invasive disease outcomes.
Cardiac allograft vasculopathy in heart transplant recipients from hepatitis C viremic donors
Authors: Kadosh Bernard S. , Birs Antoinette S. , Flattery Erin , Stachel Maxine , Hong Kimberly N. , Xia Yuhe , Gidea Claudia , Aslam Saima , Razzouk Louai , Saraon Tajinderpal , Goldberg Randal , Rao Shaline , Pretorius Victor , Moazami Nader , Smith Deane E. , Adler Eric D. , Reyentovich Alex 
Published: March 2024

AbstractBackgroundRecent studies suggest the transplantation of Hepatitis C (HCV) hearts from viremic donors is associated with comparable 1 year survival to nonviremic donors. Though HCV viremia is a known risk factor for accelerated atherosclerosis, data on cardiac allograft vasculopathy (CAV) outcomes are limited. We compared the incidence of CAV in heart transplant recipients from HCV viremic donors (nucleic acid amplification test positive; NAT+) compared to non‐HCV infected donors (NAT−).MethodsWe retrospectively reviewed annual coronary angiograms with intravascular ultrasound from April 2017 to August 2020 at two large cardiac transplant centers. CAV was graded according to ISHLT guidelines. Maximal intimal thickness (MIT) ≥ 0.5 mm was considered significant for subclinical disease.ResultsAmong 270 heart transplant recipients (mean age 54; 77% male), 62 patients were transplanted from NAT+ donors. CAV ≥ grade 1 was present in 8.8% of the NAT+ versus 16.8% of the NAT‐ group at 1 year, 20% versus 28.8% at 2 years, and 33.3% versus 41.5% at 3 years. After adjusting for donor age, donor smoking history, recipient BMI, recipient, hypertension, and recipient diabetes, NAT+ status did not confer increased risk of CAV (HR.80; 95% CI.45–1.40, p = 0.43) or subclinical IVUS disease (HR.87; 95% CI.58–1.30, p = 0.49). Additionally, there was no difference in the presence of rapidly progressive lesions on IVUS.ConclusionOur data show that NAT+ donors conferred no increased risk for early CAV or subclinical IVUS disease following transplantation in a cohort of heart transplant patients who were treated for HCV, suggesting the short‐term safety of this strategy to maximize the pool of available donor hearts.
Assessing the influence of graft loss on 4‐year patient survival after simultaneous pancreas‐kidney transplantation: Kaplan–Meier versus Competing Risk Analysis model
Authors: Alfaro Villanueva Lucia Alejandra , Junior Roberto Meirelles , Rangel Érika Bevilaqua , Modelli Luis Gustavo , Viana Laila Almeida , Cristelli Marina Pontello , Requião‐Moura Lúcio , Foresto Renato Demarchi , Tedesco‐Silva Helio , Pestana José Medina 
Published: March 2024

AbstractBackgroundGraft loss increases the risk of patient death after simultaneous pancreas‐kidney (SPK) transplantation. The relative risk of each graft failure is complex due to the influence of several competing events.MethodsThis retrospective, single‐center study compared 4‐year patient survival according to the graft status using Kaplan‐Meier (KM) and Competing Risk Analysis (CRA). Patient survival was also assessed according to five eras (Era 1: 2001–2003; Era 2: 2004–2006; Era 3: 2007–2009; Era 4: 2010–2012; Era 5: 2012–2015).ResultsBetween 2000 and 2015, 432 SPK transplants were performed. Using KM, patient survival was 86.5% for patients without graft loss (n = 333), 93.4% for patients with pancreas graft loss (n = 46), 43.7% for patients with kidney graft loss (n = 16), and 25.4% for patients with pancreas and kidney graft loss (n = 37). Patient survival was underestimated using KM versus CRA methods in patients with pancreas and kidney graft losses (25.4% vs. 36.2%), respectively. Induction with lymphocyte depleting antibodies was associated with 81% reduced risk (HR.19, 95% CI.38–.98, p = .0048), while delayed kidney function (HR 2.94, 95% CI 1.09–7.95, p = .033) and surgical complications (HR 2.94, 95% CI 1.22–7.08, p = .016) were associated with higher risk of death. Four‐year patient survival increased from Era 1 to Era 5 (79% vs. 87.9%, p = .047).ConclusionIn this cohort of patients, kidney graft loss, with or without pancreas graft loss, was associated with higher mortality after SPK transplantation. Compared to CRA, the KM model underestimated survival only among patients with pancreas and kidney graft losses. Patient survival increased over time.
Temperature trend and corporate cash holdings
Authors: Gounopoulos Dimitrios , Zhang Yu 
Published: March 2024

AbstractWe examine the causal impact of climate uncertainty on companies’ cash holdings using local temperature trends. We find a notable increase in cash reserves among companies in response to rising climate‐related risks. We also identify two significant channels through which climate uncertainty influences firms’ cash management: heightened environmental enforcement risk and increased physical risk. Furthermore, we observe that the positive effect of temperature trends on cash holdings is more pronounced for financially constrained firms and those with a lower level of environmental protection awareness. External financing through equity and debt issuance, as well as cost reduction strategies involving research and development and selling, general, and administrative activities, represent viable avenues for firms to bolster their cash reserves. However, financially constrained firms are less inclined to build up cash reserves through debt financing. Our findings underscore the precautionary nature of corporate cash policies and shed light on how temperature fluctuations can significantly shape corporate behavior.
Relativizing Relativism? Variations on a Theme in Pope Benedict XVI and Pope Francis
Authors: Wahl Michael A. 
Published: March 2024

AbstractWhile the rise of a ‘dictatorship of relativism’ was a longstanding concern for Joseph Ratzinger/Pope Benedict XVI, some commentators have suggested that—for better or for worse—the challenge posed by relativism appears to be less of a priority for Pope Francis. Indeed, Francis's remark, ‘Who am I to judge?’ appears to have become as much the defining soundbite for his papacy as the ‘dictatorship of relativism’ was for Benedict's. Contrary to these perceptions, this article argues that a critique of relativism is in fact a central aspect of Pope Francis's magisterium. Francis exhibits continuity with Benedict by amplifying his concerns about the danger of attempting to reconstruct reality according to human desire, but Francis also develops his predecessor's teaching by introducing the category of ‘practical relativism’. With this development, relativism cannot be dismissed as a theoretical problem that only plagues those who refuse to assent to the truth intellectually. The willingness to set aside the truth to which one assents when it proves inconvenient represents a more pernicious—precisely because more subtle—form of relativism that Francis argues must be rooted out, not by argument, but through self‐examination and the practice of solidarity.
RETRACTED: The impact of inflammatory biomarkers on amputation rates in patients with diabetic foot ulcers
Authors: Xu Yun , Geng Ruina , Meng Xiangyu , Feng Zhipeng , Wang Xu , Zhang Guanying , Bai Liwei 
Published: March 2024

AbstractDiabetic Foot Ulcers (DFUs) are a major complication of diabetes, often leading to amputation. Understanding the relationship between haematological inflammatory markers and the incidence of amputation in DFU patients with infectious complications is crucial for improving management and outcomes. This retrospective study, conducted from May 2020 to October 2022, involved 109 patients with DFUs, categorised into amputation (AM) and non‐amputation (NAM) groups. Patients were evaluated for various factors, including demographic data, DFU duration, and blood parameters such as haemoglobin A1c (HbA1c), haemoglobin (Hb), albumin (ALB), white blood cell count (WBC), erythrocyte sedimentation rate (ESR), procalcitonin (PCT), C‐reactive protein (CRP), platelet‐to‐lymphocyte ratio (PLR), neutrophil‐to‐lymphocyte ratio (NLR), and lymphocyte‐to‐monocyte ratio (LMR). Statistical analyses were performed using independent sample t‐tests, Mann–Whitney U test and logistic regression. The univariate analysis showed no significant difference in BMI, DM duration or DFU duration between groups. However, significant differences were noted in PCT, Hb, ESR, ALB, HbA1c and WBC levels, and in inflammatory ratios (NLR, PLR and LMR). Multivariate logistic regression identified CRP, NLR and PLR as independent risk factors for amputation. The study highlights CRP, PLR and NLR as key independent risk factors for amputation in patients with DFUs. These easily obtainable markers from routine blood tests can effectively aid in predicting the risk of osteomyelitis and amputation, enhancing clinical decision making and patient care strategies.
Use of the Japanese gestational diabetes mellitus diagnostic strategy during the COVID‐19 pandemic in Japan: A questionnaire survey
Authors: Kasuga Yoshifumi , Miyakoshi Kei , Yokoyama Maki , Nakanishi Sayuri , Iwama Noriyuki , Ichikawa Raishi , Abiko Atsuko , Harashima Shinichi , Sugiyama Takashi 
Published: March 2024

AbstractAimSome concerns exist that diagnosis of gestational diabetes mellitus (GDM) may be missed when the simplified diagnostic criteria of the Japanese Society of Diabetes and Pregnancy (JSDP) for GDM (published during the COVID‐19 pandemic) are used. Moreover, limited data is available regarding how widespread these diagnostic criteria are used when managing GDM during the COVID‐19 pandemic. Therefore, this study aimed to determine how GDM diagnosis has changed during the COVID‐19 pandemic in Japan.MethodsThe changes in GDM diagnosis during the COVID‐19 pandemic were investigated using an online questionnaire to 2159 obstetric facilities in Japan. The questionnaire collected data on facility type, awareness of Japanese GDM diagnostic strategies, modifications to diagnostic methods for early and late GDM, and opinions on GDM management, with the pandemic divided into seven periods.ResultsWe received responses from 593 facilities (27%). Approximately 90% of the facilities did not change their diagnostic process for early GDM or late GDM (occurring after 24 weeks gestation). However, during the COVID‐19 pandemic, 19 facilities discontinued the use of 75‐g oral glucose tolerance tests before 24 weeks of gestation, and 17 facilities discontinued it after 24 weeks of gestation, instead using the aforementioned Japanese GDM diagnostic strategy.ConclusionsAlthough a limited number of facilities modified their diagnostic method in response to the COVID‐19 pandemic, this study demonstrated that those that adjusted their diagnostic method primarily used the Japanese COVID‐19 GDM strategy by the JSDP.
To be, or not to be? Copyright general monitoring dilemma of online hosting audio‐visual platforms in China
Authors: Lu Yue 
Published: March 2024

AbstractIn China, a hosting audio‐visual platform does not bear a copyright general monitoring obligation. It bears a public law obligation to monitor content proactively and constantly to safeguard the governance objective of cybersecurity. Little literature has discovered that Chinese case law has shown a risk that this public law obligation can impose an actual copyright general monitoring obligation upon platforms. The crux lies in that the public law obligation weakens the rationale of the copyright no monitoring obligation that a platform cannot access and assess each piece of work proactively. Copyright general monitoring seems to be workable as a platform is given such an opportunity to access and evaluate each content upon the fulfillment of the public law obligation. It, however, is unjustifiable to create this copyright law obligation by transferring it from the public law obligation, as copyright monitoring is much more complicated and costly within China's online environment. Access to content does not necessarily indicate a platform's ability to figure out content's copyright authorization status. China should retain adopting the no copyright general monitoring obligation even considering that the public law obligation has been contextually emphasized as a mandatory obligation to platforms.