bluuebunny/crossref_metadata_2025_split huggingface dataset:
La ultrasonografía doppler para predicción y prevención de la preeclampsia
Authors: Luna Quinto Carla Siu Mei 
Published: April 2024

PROBLEMA: La preeclampsia se encuentra entre las primeras tres causas de muerte materna en Guatemala. En países en vías de desarrollo, una mujer tiene siete veces más probabilidades de desarrollar preeclampsia, comparado con una mujer que vive en un país desarrollado. El desarrollo de estrategias de predicción y prevención puede disminuir las complicaciones y secuelas ocasionadas por dicha enfermedad. OBJETIVO: Conocer la ultrasonografía doppler para predicción y prevención de la preeclampsia. MÉTODO: Se realizó una revisión bibliográfica basada en artículos científicos, guías y manuales sobre preeclampsia, doppler de arterias uterinas y su utilidad en la predicción y prevención de preeclampsia. Se tomaron en cuenta para este estudio 15 artículos, publicados del 2003 hasta el 2022. RESULTADOS: Las evidencias actuales sobre el Doppler de arterias uterinas se han consolidado como una de las mejores herramientas para la predicción de preeclamsia, ya que dicha prueba diagnóstica refleja una sensibilidad del 47% y una especificidad del 92% para detección temprana de preeclampsia, su inclusión dentro de los diversos algoritmos que calculan el riesgo de preeclampsia entre el primer trimestre garantiza un diagnóstico oportuno y en la mayoría de casos preventivo. CONCLUSIÓN: El uso de los parámetros de medición de arterias uterinas como el índice de pulsatilidad, índice sístole/diástole y presencia de escotadura diastólica temprana, han sido propuesta como una prueba predictiva para preeclampsia en el primer trimestre de embarazo.
EDUKASI PADA WANITA USIA SUBUR TENTANG SEL TUMOR DAN KEGANASAN DI DESA TOBIMEITA KEC.MOTUI KAB. KONAWE UTARA
Authors: Nurfantri  , Muhaimin Saranani  
Published: April 2024

Latar Belakang. Saat ini Kanker menduduki urutan ketiga penyebab kematian, kategorik penyakit tidak menular.Kondisi lingkungan yang penuh dengan karsinogenik dan pola hidup tidak sehat yang dianut masyarakat semakin memperbesar peluang angka kejadian kanker. Kurangnya pengetahuan serta keterbatasan dalam mengakses informasi yang valid tentang kanker diyakini sebagai penyebab masih tingginya angka kejadian kanker di Indonesia, selain itu akan mempengaruhi persepsi dan sikap masyarakat untuk melakukan deteksi dini. Tujuan : Meningkatkan pengetahuan masyarakat Masalah Kesehatan Sistem Reproduksi pada wanita usia subur, Simulasi Cara Pemeriksaan Payudara Sendiri (SADARI). Metode. Pemberian edukasi dilakukan dalam bentuk penyuluhan dan demonstrasi, Sasaran kegiatan ini adalah wanita usia subur di desa Tobimeita Kec.Motui Kab. Konawe Utara, berjumlah 30 orang. Indikator keberhasilan intervensi melalui pengukuran tingkat pengetahuan, yang dilakukan sebelum dan sesudah melakukan edukasi, Hasil. Ditemukan perubahan jumlah tingkat pengetahuan responden sebelum dan sesudah pemberian edukasi, nampak persentase responden berpengetahuan kurang (15 responden atau 50%) dan cukup sebanyak 7 responden atau 23,3 % mengalami penurunan dengan jumlah responden berpengetahuan rendah menjadi 6 responden (20%) dan berpengetahuan cukup meningkat menjadi 13 responden (43%), sehingga persentase responden berpengetahuan baik yang sebelumnya sebesar 8 responden ( 26,6%) mengalami peningkatan menjadi 11 responden (36,6%).
Histopathology and micronuclei induction as pollution biomarkers in common carp, Cyprinus carpio from southern Iraq
Authors: Yasser Amaal , Al-Kaaby Israa , Shabeeb Ahmed , Naser Murtada , Auda Nabaa , Ajeel Shaker , Yesser Abdulkareem , Al-Hello Abdel-Zahra , Lebepe Jeffrey 
Published: April 2024

This study aimed to assess the histopathological alterations and micronuclei induction in the gill, kidney and liver of common carp, Cyprinus carpio from Al-Huwaizah Marshes, Al-Hammar Marshes and Al-Sweap River. Thirty C. carpio were sampled at each locality using monofilament gillnets. Most prominent histopathological alterations recorded in the gill included formation venous sinus in primary lamellae, oedema, curling and distortion of primary lamellae fusion of secondary lamellae, hyperplasia of epithelial cells, necrosis, curling of secondary lamellae, severe dilation of lamellar capillaries, clavate lamellae formation at the tip of secondary lamellae, a proliferation of cartilage tissue in primary lamellae and lifting of the lamellar epithelium whereas congestion, fibrosis with proliferative inflammation, necrosis area, degenerated cells, vacuolar degeneration, vacuolation, nuclear pyknosis, hypertrophy of hepatocytes were reported in the liver. In the kidney, the most pronounced changes were necrosis of the hematopoietic tissue, hyaline droplet and activation of melanomacrophage centres. A higher prevalence of alterations was observed in the population from Al-Huwaizah Marshes, however, Al-Hammar population exhibited severe pathologies. Micronuclei frequency was significantly higher at Al-Huwaizah Marsh (p < 0.05) with low frequency being recorded at Al-Sweap River. This study attests to the effectiveness of histopathology and micronucleus induction as potential tools for discriminating the health of populations from different water bodies.
Comparison of Long-term Outcomes between Hirschsprung's Disease Patients after Soave Procedure and Duhamel Procedure Based on the Paediatric Incontinence and Constipation Scoring System: A Retrospective Cohort Study
Authors: Sentoso Joko Wibowo , Agustriani Nunik , SA Ida Bagus Budhi 
Published: April 2024

Introduction: Hirschprung's disease is a congenital disease that causes intestinal motility disorders. Hirschprung's disease is still the most common condition that causes intestinal obstruction in children. The incidence of Hirschprung's disease is 1:5000 live births. The incidence ratio of this disease is around 4:1 between men and women, with a higher percentage of men 1,3,4. Approximately 75% of cases of Hirschprung's disease occur in the rectosigmoid colon area, 17% in the splenic flexure or transverse colon and 8% along the colon and terminal ileum. The Duhamel technique still remains a popular procedure most surgeons especially for long segment treatment and redo procedures.28, 30 The advantage of the Duhamel Procedure is that it is easy to perform, reduces the risk of damage to surrounding structures such as genitourinary innervation, but has the possibility of complications of anastomotic leakage which causes fistulas and abscesses.
Materials and Methods: Total subjects of this study was 441 patients with Hirschprung's disease who were treated with the Soave procedure and the Duhamel procedure at Dr. Moewardi General Hospital in Surakarta, Central Java, Indonesia for the period January 2017 - January 2022. This type of research is descriptive analytics with a retrospective cohort.
Results: The results of the study can be concluded that patients with HAEC increases the risk of constipation. Congenital abnormalities predispose to fecal incontinence. Differences in surgical techniques do not significantly influence or increase the risk of constipation and fecal incontinence based on statistical tests. However, the increased risk of constipation and fecal incontinence is higher in patients undergoing the Duhamel surgical procedure.
Conclusion: Conclusions that can be drawn from research regarding the comparison of long-term outcomes of Hirschsprung disease patients after Soave and Duhamel operations based on the Pediatric Incontinence and Constipation Scoring System at Dr. Moewardi General Hospital in Surakarta, Indonesia for period January 2017 – January 2022, it can be concluded that there is no significant difference in the outcome of patients who underwent the Soave or Duhamel procedures. The Duhamel procedure has a higher prevalence of complications of constipation and fecal incontinence compared to the Soave procedure. The presence of HAEC before the surgical procedure increases the risk of constipation, significantly in the Soave and Duhamel procedures.
Auroville: An Architectural Laboratory
Authors: Kundoo Anupama 
Published: November 2007

AbstractArchitect Anupama Kundoo describes how ‘the dream of building a new city’ from scratch for an international spiritual community in southern India has created a magnet for architects around the world. As the city now approaches its 50th anniversary, she asks whether Auroville can keep its architectural culture of innovation and experimentation alight. Copyright © 2007 John Wiley & Sons, Ltd.
Sharifa's House
Authors: Morshed Adnan 
Published: November 2007

AbstractIn Bangladesh, a microbanking system exclusively targeted at female ‘entrepeneurs’ has been combined with a streamlined domestic construction process, transforming the possibilities of affordable housing for the rural poor. Dr Adnan Morshed tells Sharifa's story; how a very modest loan from the Grameen Bank allowed Sharifa and her family to build a house and to realise what amounts to very much more than even a permanent home. Copyright © 2007 John Wiley & Sons, Ltd.
New Coordination Modes of L‐Ascorbic Acid and Dehydro‐L‐ascorbic Acid as Dianionic Chelating Ligand for Platinum
Authors: Bergamini Paola , Marchesi Elena , Bertolasi Valerio , Fogagnolo Marco , Scarpantonio Luca , Manfredini Stefano , Vertuani Silvia , Canella Alessandro 
Published: November 2007

AbstractA variety of coordination modes of L‐ascorbic acid as an anionic bidentate ligand has been exploited to prepare platinum(II) complexes 1–7 that contain phosphanes or R,R‐dach (1R,2R‐diaminocyclohexane) as neutral ligands in which O2, O3, O5, O6 and C2 act as anionic donating functionalities. An alternative synthetic route to known O2,O3 complexes is proposed, and their solubility in water has been enhanced by introducing PTA (1,3,5‐triaza‐7‐phosphaadamantane) as a neutral ligand. A new coordination mode of ascorbic acid (O2 and O3 protected) as an O5,O6‐diolate chelating ligand has been characterised in solution by NMR spectroscopy and in the solid state by X‐ray crystallography. The first example of a platinum complex that contains dehydroascorbic acid, 7, has also been prepared and its X‐ray crystal structure has been determined. The antiproliferative activity in vitro of complexes 1–7 has been tested, and the best values were obtained for the DHA complex 7, which was found to be more active than cisplatin on both a cisplatin‐sensitive and a cisplatin‐resistant cell line.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Advances in CE for kinetic studies
Authors: Newman Carl I. D. , Collins Greg E. 
Published: November 2007

AbstractCE is a promising technique for the investigation of molecular interactions because it affords evaluation of multiple interaction modes, does not require immobilization of molecules, and has no dead time. In order to perform these investigations, numerous methods have been developed for determining binding constants and other thermodynamic parameters. These methods have been reviewed extensively in recent years. However, methods for determining the rates of reaction are less prolific. Nonetheless, numerous theoretical and experimental advances have been made in recent years to address this discrepancy. Some of these methods employ computer simulations to determine first‐order or second‐order rate constants numerically, whereas other methods calculate rate constants directly as solutions to analytical equations. It is the object of this review to provide descriptions of these methods in terms of their underlying assumptions, experimental methodology, calculation of rate constants, and inherent limitations.
Multilevel evaluation process use in large‐scale multisite evaluation
Authors: Lawrenz Frances , Huffman Douglas , McGinnis J. Randy 
Published: November 2007

AbstractThis chapter describes the issues surrounding evaluation process use in a large, national, multilevel, multisite evaluation funded by the National Science Foundation. Two key questions that emerge from this chapter are to what extent a multilevel core evaluation can affect evaluation process use and what types of process use can be affected.
Four methods for completing the conceptual development phase of applied theory building research in HRD
Authors: Storberg‐Walker Julia , Chermack Thomas J. 
Published: November 2007

AbstractThe purpose of this article is to describe four methods for completing the conceptual development phase of theory building research for single or multiparadigm research. The four methods selected for this review are (1) Weick's method of “theorizing as disciplined imagination” (1989); (2) Whetten's method of “modeling as theorizing” (2002); (3) Chermack's method of “scenario planning as theorizing” (2006); and (4) Storberg‐ Walker's method of “five components of conceptual development” (2007b). Each method is described in detail with a goal of providing readers with four alternative ways of approaching and completing the conceptual development phase. We present the methods from more to less abstract, beginning with a method illuminating the imaginative aspects of conceptual development and ending with a method that illuminates specific and interdependent cognitive tasks involved with conceptual development. These four methods cover a broad spectrum of ideas on how to best complete this most challenging component of theory building.
Marked regression of liver metastasis by combined therapy of ultrasound‐mediated NFkB‐decoy transfer and transportal injection of paclitaxel, in mouse
Authors: Azuma Haruhito , Tomita Naruya , Sakamoto Takeshi , Kiyama Satoshi , Inamoto Teruo , Takahara Kiyoshi , Kotake Yatsugu , Segawa Naoki , Morishita Ryuichi , Takahara Shiro , Hayasaki Hana , Otsuki Yoshinori , Horie Shigeo , Tanigawa Nobuhiko , Katsuoka Yoji 
Published: November 2007

AbstractNuclear factor‐kappaB (NFkB) plays a pivotal role in cancer progression. In this study, we developed a decoy cis‐element oligo‐deoxyribonucleic acid against NFkB‐binding site (NFkB‐decoy), which effectively inhibits NFkB activity, and tested the effect of combined therapy comprising local transfection of NFkB‐decoy into the liver and transportal injection of paclitaxel on cancer growth and metastasis using an orthotopic murine model of colon cancer liver metastasis. For NFkB‐decoy transfection, we employed a novel approach using ultrasound exposure with an echocardiographic contrast agent, Optison. We examined the influence of NFkB‐decoy transfer on susceptibility to paclitaxel in cancer cells and the mechanism involved using several in vitro analysis systems. We then studied the in vivo effect of combined NFkB‐decoy transfer and paclitaxel in preventing cancer progression using a murine model of liver metastasis created by splenic injection of a human colon cancer cell line, HT29. In vitro experiments, including MTT‐assay, fluorescence‐activated cell sorter and cDNA array analysis, revealed that NFkB‐decoy transfer significantly increased the susceptibility of cancer cells to paclitaxel, and that decreased expression of anti‐apoptotic genes along with increased expression of genes relevant to the apoptosis‐promotor may be involved. In vivo experiments showed that local transfection of NFkB‐decoy into the liver followed by portal injection of paclitaxel effectively induced cancer cell apoptosis in the liver metastasis, and significantly prolonged animal survival compared to controls, without notable side effects. In conclusion, a combination of local NFkB‐decoy transfer into the liver and transportal injection of paclitaxel may be a safe and effective new therapy for liver metastasis. © 2007 Wiley‐Liss, Inc.
The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma
Authors: Pfister Stefan , Rea Stephen , Taipale Mikko , Mendrzyk Frank , Straub Beate , Ittrich Carina , Thuerigen Olaf , Sinn Hans Peter , Akhtar Asifa , Lichter Peter 
Published: November 2007

AbstractLoss of H4 lysine 16 (H4K16) acetylation was shown to be a common feature in human cancer. However, it remained unclear which enzyme is responsible for the loss of this modification. Having recently identified the histone acetyltransferase human MOF (hMOF) to be required for bulk H4K16 acetylation, here we examined the involvement of hMOF expression and H4K16 acetylation in breast cancer and medulloblastoma. Analysis of a recent mRNA expression profiling study in breast cancer (n = 100 cases) and an array‐CGH screen in medulloblastomas (n = 102 cases), revealed downregulation in 40% and genomic loss in 11% of cases, respectively. We investigated hMOF protein expression as well as H4K16 acetylation in large series of primary breast carcinomas (n = 298) and primary medulloblastomas (n = 180) by immunohistochemistry. In contrast to nontransformed control tissues, significant fractions of both primary breast carcinomas and medulloblastomas showed markedly reduced hMOF mRNA and protein expression. In addition, hMOF protein expression tightly correlated with acetylation of H4K16 in all tested samples. For medulloblastoma, downregulation of hMOF protein expression was associated with lower survival rates identifying hMOF as an independent prognostic marker for clinical outcome in univariate as well as multivariate analyses. © 2007 Wiley‐Liss, Inc.
Involvement of JNK/p73/NOXA in vitamin E analog‐induced apoptosis of human breast cancer cells
Authors: Wang Pei , Yu Weiping , Hu Zhanzhi , Jia Li , Iyer Vishwanath R. , Sanders Bob G. , Kline Kimberly 
Published: November 2007

AbstractMicroarray analyses of human MDA‐MB‐435 breast cancer cells treated with vitamin E analog 2,5,7,8‐tetramethyl‐2R‐(4R,8R,12‐trimethyltridecyl) chroman‐6‐yloxy acetic acid (α‐TEA) showed over 400 genes to be modulated. Thirty‐four genes deemed of interest based on potential involvement in anticancer activities of α‐TEA fell into six categories: apoptosis related, signal transduction, cell cycle related, cell adhesion and motility, transcriptional regulators, and membrane traffic related. The gene (PMAIP1) for NOXA was studied further. NOXA mRNA and protein levels were elevated in a time and dose‐dependent fashion following α‐TEA treatment. Functional knockdowns using small interfering RNA (siRNA) showed NOXA to contribute to α‐TEA‐induced apoptosis. A correlation between α‐TEA's ability to upregulate NOXA and induce apoptosis was seen among several human breast cancer cell lines. Efforts to identify upstream regulators of NOXA in α‐TEA‐induced apoptosis identified the necessity of both c‐Jun N‐terminal kinase (JNK) activation and p73 expression. Additionally, protein levels of full length p73 were decreased by JNK siRNA treatment, suggesting that the signal transduction module of JNK‐p73‐NOXA is involved in α‐TEA induced apoptosis of human breast cancer cells. Taken together, these findings suggest a role for JNK activation in mediating full length p73 expression and add to our understanding of the mechanisms of anticancer actions of α‐TEA, a potential chemotherapeutic agent. © 2007 Wiley‐Liss, Inc.
Interrelationships between dietary restriction, the IGF‐I axis, and expression of vascular endothelial growth factor by prostate adenocarcinoma in rats
Authors: Powolny Anna A. , Wang Shihua , Carlton Peter S. , Hoot Dahlys R. , Clinton Steven K. 
Published: November 2007

AbstractHuman studies suggest that excessive energy intake and obesity may influence prostate cancer progression. Rodent experiments demonstrate that diet restriction attenuates tumor growth in parallel with reduced vascular density. The present study examines changes in the insulin‐like growth factor I (IGF‐I) axis caused by dietary restriction and their association with the expression of vascular endothelial growth factor (VEGF) in prostate cancer. Weanling male Copenhagen rats were randomized into control or 40% dietary restricted groups (n = 5). After 8 wk, rats were implanted with rat AT6.3 prostate adenocarcinoma cells. Two weeks later, the animals were sacrificed and serum, normal prostate, liver, and prostate tumor samples were collected for analyses. Dietary restriction reduced serum concentrations of IGF‐I by 35% (P < 0.05) and increased IGF‐binding protein‐3 (IGFBP3) by sevenfold (P < 0.0001). Lower circulating IGF‐I concentrations were correlated with reduced IGF‐I mRNA expression in the liver, the primary source of circulating IGF‐I. Dietary restriction also lowered mRNA expression of IGF‐I (45%, P = 0.0242) and its receptor IGFIR (40%, P = 0.0083) in prostate tumors. Similarly, reduced VEGF mRNA (30%, P = 0.0176) and secreted VEGF protein (33%, P = 0.0003) were observed in prostate cancer of restricted rats. An in vitro study employing AT6.3 prostate cancer cells demonstrated dose‐ and time‐dependent stimulation of VEGF expression by IGF‐I. These results suggest that dietary restriction reduces endocrine and prostate tumor autocrine/paracrine IGF‐I expression, which contributes to reduced VEGF expression and signaling, to inhibit tumor angiogenesis associated with prostate tumorigenesis. © 2007 Wiley‐Liss, Inc.
A survey of sesamin and composition of tocopherol variability from seeds of eleven diverse sesame (Sesamum indicum L.) genotypes using HPLC‐PAD‐ECD
Authors: Williamson Kelly S. , Morris J. Brad , Pye Quentin N. , Kamat Chandrashekhar D. , Hensley Kenneth 
Published: November 2007

AbstractThe objective of this study was to determine the composition and content of sesamin and desmethyl tocopherols such as α‐tocopherol (αT), δ‐tocopherol (δT) and γ‐tocopherol (γT) in seeds of sesame (Sesamum indicum L.) for 11 genotypes conserved in the United States Department of Agriculture (USDA), Agricultural Research Service (ARS) and Plant Genetic Resources Conservation Unit (PGRCU) in Griffin, Georgia, USA. Seed accessions studied were collections from eight countries worldwide, including one landrace from Thailand and two cultivars from Texas, USA. Novel methodologies and analytical techniques described herein consisted of reverse‐phase high‐performance liquid chromatography (HPLC) connected in series with two detection systems specific for each analyte class. Photodiode array detection was employed for sesamin analysis and electrochemical array detection was used in the determination of tocopherols. A preliminary study was conducted to assess sesamin levels in 2003 and tocopherol levels in 2004 from sesame seed samples conserved at the USDA, ARS and PGRCU. In 2005, sesame seed samples were grown, harvested and evaluated for sesamin as well as tocopherol levels. The overall results (n = 3) showed that sesamin, αT, δT and γT levels were 0.67–6.35 mg/g, 0.034–0.175 µg/g, 0.44–3.05 µg/g and 56.9–99.3 µg/g respectively, indicating that the sesame seed accessions contained higher levels of sesamin and γT compared with αT and δT. Statistical analysis was conducted and significant differences were observed among the 11 different sesame genotypes. This suggests that genetic, environmental and geographical factors influence sesamin and desmethyl tocopherol content. Copyright © 2007 John Wiley & Sons, Ltd.
Crystal Structures of NbOI3 and NbOBr3 – Polar Double Chains in Different Non‐centrosymmetric Structures
Authors: Hartwig Sabina , Hillebrecht Harald 
Published: November 2007

AbstractNbOI3 was obtained from a reaction of Nb2O5, Nb, and I2. Single crystals free from disorder were a by‐product from a reaction with additional CsI. The monoclinic crystal structure (C2, a = 14.624(3) Å, b = 3.9905(8) Å, c = 12.602(3) Å, β = 120.4(3)°, Z = 4, R1(F) = 0.0368, wR2(F2) = 0.0804) represents a new structure type which is built up by distorted octahedral NbI4O2 with unequal O‐atoms in trans‐position. The octahedra are linked to dimers by a common edge of iodine atoms and to double chains by the apical oxygen atoms. A non‐centrosymmetric structure results because the short Nb–O distances point to the same direction and the polar double chains are parallel. The crystal structure of NbOBr3 (NbOCl3‐type, $P{\bar 4}{\rm 2_{1}}m$, a = 11.635(6) Å, c = 3.953(2) Å, R1(F) = 0.082, wR2(F2) = 0.174) shows the same polar double chains but the dimeric units Nb2Br6O2 are orthogonal.